id	sid	tid	token	lemma	pos
admet-909	1	1	evaluation	evaluation	NOUN
admet-909	1	2	of	of	ADP
admet-909	1	3	pharmacokinetics	pharmacokinetic	NOUN
admet-909	1	4	of	of	ADP
admet-909	1	5	warfarin	warfarin	NOUN
admet-909	1	6	from	from	ADP
admet-909	1	7	validated	validate	VERB
admet-909	1	8	pharmacokinetic	pharmacokinetic	ADJ
admet-909	1	9	-	-	PUNCT
admet-909	1	10	pharmacodynamic	pharmacodynamic	ADJ
admet-909	1	11	model	model	NOUN
admet-909	1	12	doi	doi	PROPN
admet-909	1	13	:	:	PUNCT
admet-909	1	14	https://dx.doi.org/10.5599/admet.909	https://dx.doi.org/10.5599/admet.909	PROPN
admet-909	1	15	143	143	NUM
admet-909	1	16	admet	admet	PROPN
admet-909	1	17	&	&	CCONJ
admet-909	1	18	dmpk	dmpk	PROPN
admet-909	1	19	9(2	9(2	NUM
admet-909	1	20	)	)	PUNCT
admet-909	1	21	(	(	PUNCT
admet-909	1	22	2021	2021	NUM
admet-909	1	23	)	)	PUNCT
admet-909	1	24	143	143	NUM
admet-909	1	25	-	-	SYM
admet-909	1	26	149	149	NUM
admet-909	1	27	;	;	PUNCT
admet-909	1	28	doi	doi	NOUN
admet-909	1	29	:	:	PUNCT
admet-909	1	30	https://doi.org/10.5599/admet.909	https://doi.org/10.5599/admet.909	ADJ
admet-909	1	31	open	open	ADJ
admet-909	1	32	access	access	NOUN
admet-909	1	33	:	:	PUNCT
admet-909	1	34	issn	issn	PROPN
admet-909	1	35	:	:	PUNCT
admet-909	1	36	1848	1848	NUM
admet-909	1	37	-	-	SYM
admet-909	1	38	7718	7718	NUM
admet-909	1	39	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-909	1	40	original	original	ADJ
admet-909	1	41	scientific	scientific	ADJ
admet-909	1	42	paper	paper	NOUN
admet-909	1	43	evaluation	evaluation	NOUN
admet-909	1	44	of	of	ADP
admet-909	1	45	pharmacokinetics	pharmacokinetic	NOUN
admet-909	1	46	of	of	ADP
admet-909	1	47	warfarin	warfarin	NOUN
admet-909	1	48	from	from	ADP
admet-909	1	49	validated	validate	VERB
admet-909	1	50	pharmacokinetic	pharmacokinetic	ADJ
admet-909	1	51	-	-	PUNCT
admet-909	1	52	pharmacodynamic	pharmacodynamic	ADJ
admet-909	1	53	model	model	NOUN
admet-909	1	54	kannan	kannan	PROPN
admet-909	1	55	sridharan1	sridharan1	PROPN
admet-909	1	56	*	*	PROPN
admet-909	1	57	,	,	PUNCT
admet-909	1	58	rashed	rashe	VERB
admet-909	1	59	al	al	PROPN
admet-909	1	60	banna2	banna2	PROPN
admet-909	1	61	,	,	PUNCT
admet-909	1	62	aysha	aysha	PROPN
admet-909	1	63	husain2,3	husain2,3	PROPN
admet-909	1	64	1	1	NUM
admet-909	1	65	department	department	NOUN
admet-909	1	66	of	of	ADP
admet-909	1	67	pharmacology	pharmacology	PROPN
admet-909	1	68	&	&	CCONJ
admet-909	1	69	therapeutics	therapeutic	NOUN
admet-909	1	70	,	,	PUNCT
admet-909	1	71	college	college	NOUN
admet-909	1	72	of	of	ADP
admet-909	1	73	medicine	medicine	PROPN
admet-909	1	74	&	&	CCONJ
admet-909	1	75	medical	medical	ADJ
admet-909	1	76	sciences	sciences	PROPN
admet-909	1	77	,	,	PUNCT
admet-909	1	78	arabian	arabian	PROPN
admet-909	1	79	gulf	gulf	PROPN
admet-909	1	80	university	university	PROPN
admet-909	1	81	,	,	PUNCT
admet-909	1	82	manama	manama	PROPN
admet-909	1	83	,	,	PUNCT
admet-909	1	84	kingdom	kingdom	NOUN
admet-909	1	85	of	of	ADP
admet-909	1	86	bahrain	bahrain	NOUN
admet-909	1	87	.	.	PUNCT
admet-909	2	1	2	2	NUM
admet-909	2	2	department	department	NOUN
admet-909	2	3	of	of	ADP
admet-909	2	4	cardiology	cardiology	NOUN
admet-909	2	5	,	,	PUNCT
admet-909	2	6	salmaniya	salmaniya	VERB
admet-909	2	7	medical	medical	ADJ
admet-909	2	8	hospital	hospital	NOUN
admet-909	2	9	,	,	PUNCT
admet-909	2	10	ministry	ministry	PROPN
admet-909	2	11	of	of	ADP
admet-909	2	12	health	health	PROPN
admet-909	2	13	,	,	PUNCT
admet-909	2	14	manama	manama	PROPN
admet-909	2	15	,	,	PUNCT
admet-909	2	16	kingdom	kingdom	NOUN
admet-909	2	17	of	of	ADP
admet-909	2	18	bahrain	bahrain	NOUN
admet-909	2	19	.	.	PUNCT
admet-909	3	1	3	3	NUM
admet-909	3	2	rcsi	rcsi	ADJ
admet-909	3	3	-	-	PUNCT
admet-909	3	4	mub	mub	NOUN
admet-909	3	5	,	,	PUNCT
admet-909	3	6	manama	manama	PROPN
admet-909	3	7	,	,	PUNCT
admet-909	3	8	kingdom	kingdom	NOUN
admet-909	3	9	of	of	ADP
admet-909	3	10	bahrain	bahrain	NOUN
admet-909	3	11	full	full	ADJ
admet-909	3	12	affiliation	affiliation	NOUN
admet-909	3	13	,	,	PUNCT
admet-909	3	14	address	address	NOUN
admet-909	3	15	*	*	PUNCT
admet-909	3	16	corresponding	correspond	VERB
admet-909	3	17	author	author	NOUN
admet-909	3	18	:	:	PUNCT
admet-909	3	19	e	e	NOUN
admet-909	3	20	-	-	NOUN
admet-909	3	21	mail	mail	NOUN
admet-909	3	22	:	:	PUNCT
admet-909	3	23	skannandr@gmail.com	skannandr@gmail.com	NOUN
admet-909	3	24	;	;	PUNCT
admet-909	3	25	orcid	orcid	NOUN
admet-909	3	26	-	-	PUNCT
admet-909	3	27	id	id	NOUN
admet-909	3	28	:	:	PUNCT
admet-909	3	29	0000	0000	NUM
admet-909	3	30	-	-	PUNCT
admet-909	3	31	0003	0003	NUM
admet-909	3	32	-	-	PUNCT
admet-909	3	33	3811	3811	NUM
admet-909	3	34	-	-	SYM
admet-909	3	35	6503	6503	NUM
admet-909	3	36	received	receive	VERB
admet-909	3	37	:	:	PUNCT
admet-909	3	38	september	september	PROPN
admet-909	3	39	21	21	NUM
admet-909	3	40	,	,	PUNCT
admet-909	3	41	2020	2020	NUM
admet-909	3	42	;	;	PUNCT
admet-909	3	43	revised	revise	VERB
admet-909	3	44	:	:	PUNCT
admet-909	3	45	january	january	PROPN
admet-909	3	46	06	06	NUM
admet-909	3	47	,	,	PUNCT
admet-909	3	48	2021	2021	NUM
admet-909	3	49	;	;	PUNCT
admet-909	3	50	published	publish	VERB
admet-909	3	51	online	online	ADV
admet-909	3	52	:	:	PUNCT
admet-909	3	53	january	january	PROPN
admet-909	3	54	18	18	NUM
admet-909	3	55	,	,	PUNCT
admet-909	3	56	2021	2021	NUM
admet-909	3	57	abstract	abstract	ADJ
admet-909	3	58	background	background	NOUN
admet-909	3	59	:	:	PUNCT
admet-909	3	60	pharmacokinetics	pharmacokinetic	NOUN
admet-909	3	61	of	of	ADP
admet-909	3	62	warfarin	warfarin	NOUN
admet-909	3	63	has	have	AUX
admet-909	3	64	not	not	PART
admet-909	3	65	been	be	AUX
admet-909	3	66	described	describe	VERB
admet-909	3	67	in	in	ADP
admet-909	3	68	our	our	PRON
admet-909	3	69	population	population	NOUN
admet-909	3	70	.	.	PUNCT
admet-909	4	1	we	we	PRON
admet-909	4	2	derived	derive	VERB
admet-909	4	3	the	the	DET
admet-909	4	4	pharmacokinetic	pharmacokinetic	ADJ
admet-909	4	5	parameters	parameter	NOUN
admet-909	4	6	from	from	ADP
admet-909	4	7	a	a	DET
admet-909	4	8	validated	validate	VERB
admet-909	4	9	pharmacokinetic	pharmacokinetic	ADJ
admet-909	4	10	-	-	PUNCT
admet-909	4	11	pharmacodynamic	pharmacodynamic	ADJ
admet-909	4	12	model	model	NOUN
admet-909	4	13	.	.	PUNCT
admet-909	5	1	methods	method	NOUN
admet-909	5	2	:	:	PUNCT
admet-909	5	3	patients	patient	NOUN
admet-909	5	4	receiving	receive	VERB
admet-909	5	5	warfarin	warfarin	NOUN
admet-909	5	6	for	for	ADP
admet-909	5	7	at	at	ADV
admet-909	5	8	least	least	ADV
admet-909	5	9	6	6	NUM
admet-909	5	10	months	month	NOUN
admet-909	5	11	were	be	AUX
admet-909	5	12	recruited	recruit	VERB
admet-909	5	13	and	and	CCONJ
admet-909	5	14	their	their	PRON
admet-909	5	15	demographic	demographic	ADJ
admet-909	5	16	characteristics	characteristic	NOUN
admet-909	5	17	,	,	PUNCT
admet-909	5	18	prothrombin	prothrombin	ADJ
admet-909	5	19	time	time	NOUN
admet-909	5	20	international	international	ADJ
admet-909	5	21	normalized	normalize	VERB
admet-909	5	22	ratio	ratio	NOUN
admet-909	5	23	(	(	PUNCT
admet-909	5	24	pt	pt	PROPN
admet-909	5	25	-	-	PUNCT
admet-909	5	26	inr	inr	NOUN
admet-909	5	27	)	)	PUNCT
admet-909	5	28	,	,	PUNCT
admet-909	5	29	warfarin	warfarin	NOUN
admet-909	5	30	doses	dose	NOUN
admet-909	5	31	and	and	CCONJ
admet-909	5	32	concomitant	concomitant	ADJ
admet-909	5	33	drugs	drug	NOUN
admet-909	5	34	were	be	AUX
admet-909	5	35	collected	collect	VERB
admet-909	5	36	.	.	PUNCT
admet-909	6	1	using	use	VERB
admet-909	6	2	a	a	DET
admet-909	6	3	validated	validate	VERB
admet-909	6	4	pharmacokinetic	pharmacokinetic	ADJ
admet-909	6	5	-	-	PUNCT
admet-909	6	6	pharmacodynamic	pharmacodynamic	ADJ
admet-909	6	7	model	model	NOUN
admet-909	6	8	,	,	PUNCT
admet-909	6	9	we	we	PRON
admet-909	6	10	predicted	predict	VERB
admet-909	6	11	maximum	maximum	ADJ
admet-909	6	12	plasma	plasma	NOUN
admet-909	6	13	concentration	concentration	NOUN
admet-909	6	14	(	(	PUNCT
admet-909	6	15	cmax	cmax	NOUN
admet-909	6	16	)	)	PUNCT
admet-909	6	17	,	,	PUNCT
admet-909	6	18	total	total	ADJ
admet-909	6	19	clearance	clearance	NOUN
admet-909	6	20	(	(	PUNCT
admet-909	6	21	cl	cl	NOUN
admet-909	6	22	)	)	PUNCT
admet-909	6	23	,	,	PUNCT
admet-909	6	24	volume	volume	NOUN
admet-909	6	25	of	of	ADP
admet-909	6	26	distribution	distribution	NOUN
admet-909	6	27	(	(	PUNCT
admet-909	6	28	vd	vd	NOUN
admet-909	6	29	)	)	PUNCT
admet-909	6	30	and	and	CCONJ
admet-909	6	31	elimination	elimination	NOUN
admet-909	6	32	rate	rate	NOUN
admet-909	6	33	(	(	PUNCT
admet-909	6	34	k	k	NOUN
admet-909	6	35	)	)	PUNCT
admet-909	6	36	.	.	PUNCT
admet-909	7	1	warfarin	warfarin	NOUN
admet-909	7	2	sensitive	sensitive	ADJ
admet-909	7	3	index	index	NOUN
admet-909	7	4	(	(	PUNCT
admet-909	7	5	wsi	wsi	PROPN
admet-909	7	6	)	)	PUNCT
admet-909	7	7	and	and	CCONJ
admet-909	7	8	warfarin	warfarin	NOUN
admet-909	7	9	composite	composite	ADJ
admet-909	7	10	measures	measure	NOUN
admet-909	7	11	(	(	PUNCT
admet-909	7	12	wcm	wcm	NOUN
admet-909	7	13	)	)	PUNCT
admet-909	7	14	were	be	AUX
admet-909	7	15	estimated	estimate	VERB
admet-909	7	16	from	from	ADP
admet-909	7	17	the	the	DET
admet-909	7	18	dose	dose	NOUN
admet-909	7	19	and	and	CCONJ
admet-909	7	20	inr	inr	PROPN
admet-909	7	21	values	value	NOUN
admet-909	7	22	.	.	PUNCT
admet-909	8	1	liver	liver	NOUN
admet-909	8	2	weight	weight	NOUN
admet-909	8	3	was	be	AUX
admet-909	8	4	predicted	predict	VERB
admet-909	8	5	using	use	VERB
admet-909	8	6	validated	validated	ADJ
admet-909	8	7	formula	formula	NOUN
admet-909	8	8	.	.	PUNCT
admet-909	9	1	results	result	NOUN
admet-909	9	2	:	:	PUNCT
admet-909	9	3	two	two	NUM
admet-909	9	4	-	-	PUNCT
admet-909	9	5	hundred	hundred	NUM
admet-909	9	6	and	and	CCONJ
admet-909	9	7	twenty	twenty	NUM
admet-909	9	8	patients	patient	NOUN
admet-909	9	9	were	be	AUX
admet-909	9	10	recruited	recruit	VERB
admet-909	9	11	.	.	PUNCT
admet-909	10	1	the	the	DET
admet-909	10	2	following	follow	VERB
admet-909	10	3	were	be	AUX
admet-909	10	4	the	the	DET
admet-909	10	5	predicted	predict	VERB
admet-909	10	6	pharmacokinetic	pharmacokinetic	ADJ
admet-909	10	7	parameters	parameter	NOUN
admet-909	10	8	:	:	PUNCT
admet-909	10	9	cmax	cmax	NOUN
admet-909	10	10	(	(	PUNCT
admet-909	10	11	mg	mg	PROPN
admet-909	10	12	/	/	SYM
admet-909	10	13	l	l	NOUN
admet-909	10	14	)	)	PUNCT
admet-909	10	15	was	be	AUX
admet-909	10	16	5.8	5.8	NUM
admet-909	10	17	(	(	PUNCT
admet-909	10	18	0.4	0.4	NUM
admet-909	10	19	)	)	PUNCT
admet-909	10	20	;	;	PUNCT
admet-909	11	1	k	k	X
admet-909	11	2	(	(	PUNCT
admet-909	11	3	l	l	NOUN
admet-909	11	4	/	/	SYM
admet-909	11	5	day	day	NOUN
admet-909	11	6	)	)	PUNCT
admet-909	11	7	was	be	AUX
admet-909	11	8	1	1	NUM
admet-909	11	9	(	(	PUNCT
admet-909	11	10	0.1	0.1	NUM
admet-909	11	11	)	)	PUNCT
admet-909	11	12	;	;	PUNCT
admet-909	11	13	cl	cl	INTJ
admet-909	11	14	(	(	PUNCT
admet-909	11	15	l	l	NOUN
admet-909	11	16	/	/	SYM
admet-909	11	17	day	day	NOUN
admet-909	11	18	)	)	PUNCT
admet-909	11	19	was	be	AUX
admet-909	11	20	2.1	2.1	NUM
admet-909	11	21	(	(	PUNCT
admet-909	11	22	0.2	0.2	NUM
admet-909	11	23	)	)	PUNCT
admet-909	11	24	;	;	PUNCT
admet-909	11	25	and	and	CCONJ
admet-909	11	26	vd	vd	NOUN
admet-909	11	27	(	(	PUNCT
admet-909	11	28	l	l	NOUN
admet-909	11	29	)	)	PUNCT
admet-909	11	30	was	be	AUX
admet-909	11	31	7.6	7.6	NUM
admet-909	11	32	(	(	PUNCT
admet-909	11	33	0.2	0.2	NUM
admet-909	11	34	)	)	PUNCT
admet-909	11	35	.	.	PUNCT
admet-909	12	1	patients	patient	NOUN
admet-909	12	2	with	with	ADP
admet-909	12	3	cmax	cmax	NOUN
admet-909	12	4	and	and	CCONJ
admet-909	12	5	elimination	elimination	NOUN
admet-909	12	6	rate	rate	NOUN
admet-909	12	7	outside	outside	ADP
admet-909	12	8	the	the	DET
admet-909	12	9	mean+1.96	mean+1.96	PROPN
admet-909	12	10	sd	sd	NOUN
admet-909	12	11	had	have	VERB
admet-909	12	12	significantly	significantly	ADV
admet-909	12	13	lower	low	ADJ
admet-909	12	14	wsi	wsi	NOUN
admet-909	12	15	and	and	CCONJ
admet-909	12	16	higher	high	ADJ
admet-909	12	17	wcm	wcm	NOUN
admet-909	12	18	.	.	PUNCT
admet-909	13	1	significant	significant	ADJ
admet-909	13	2	correlations	correlation	NOUN
admet-909	13	3	were	be	AUX
admet-909	13	4	observed	observe	VERB
admet-909	13	5	between	between	ADP
admet-909	13	6	cmax	cmax	NOUN
admet-909	13	7	with	with	ADP
admet-909	13	8	cl	cl	NOUN
admet-909	13	9	,	,	PUNCT
admet-909	13	10	vd	vd	NOUN
admet-909	13	11	,	,	PUNCT
admet-909	13	12	and	and	CCONJ
admet-909	13	13	k	k	PROPN
admet-909	13	14	of	of	ADP
admet-909	13	15	warfarin	warfarin	NOUN
admet-909	13	16	.	.	PUNCT
admet-909	14	1	significant	significant	ADJ
admet-909	14	2	correlations	correlation	NOUN
admet-909	14	3	were	be	AUX
admet-909	14	4	also	also	ADV
admet-909	14	5	observed	observe	VERB
admet-909	14	6	between	between	ADP
admet-909	14	7	cl	cl	NOUN
admet-909	14	8	and	and	CCONJ
admet-909	14	9	vd	vd	NOUN
admet-909	14	10	of	of	ADP
admet-909	14	11	warfarin	warfarin	NOUN
admet-909	14	12	with	with	ADP
admet-909	14	13	liver	liver	NOUN
admet-909	14	14	weight	weight	NOUN
admet-909	14	15	of	of	ADP
admet-909	14	16	the	the	DET
admet-909	14	17	study	study	NOUN
admet-909	14	18	participants	participant	NOUN
admet-909	14	19	.	.	PUNCT
admet-909	15	1	conclusion	conclusion	NOUN
admet-909	15	2	:	:	PUNCT
admet-909	15	3	we	we	PRON
admet-909	15	4	predicted	predict	VERB
admet-909	15	5	pharmacokinetic	pharmacokinetic	ADJ
admet-909	15	6	parameters	parameter	NOUN
admet-909	15	7	of	of	ADP
admet-909	15	8	warfarin	warfarin	NOUN
admet-909	15	9	from	from	ADP
admet-909	15	10	the	the	DET
admet-909	15	11	validated	validate	VERB
admet-909	15	12	pharmacokinetic	pharmacokinetic	ADJ
admet-909	15	13	-	-	PUNCT
admet-909	15	14	pharmacodynamic	pharmacodynamic	ADJ
admet-909	15	15	model	model	NOUN
admet-909	15	16	in	in	ADP
admet-909	15	17	our	our	PRON
admet-909	15	18	population	population	NOUN
admet-909	15	19	.	.	PUNCT
admet-909	16	1	more	more	ADJ
admet-909	16	2	studies	study	NOUN
admet-909	16	3	are	be	AUX
admet-909	16	4	needed	need	VERB
admet-909	16	5	exploring	explore	VERB
admet-909	16	6	the	the	DET
admet-909	16	7	relationship	relationship	NOUN
admet-909	16	8	between	between	ADP
admet-909	16	9	various	various	ADJ
admet-909	16	10	pharmacodynamic	pharmacodynamic	ADJ
admet-909	16	11	indices	index	NOUN
admet-909	16	12	of	of	ADP
admet-909	16	13	warfarin	warfarin	NOUN
admet-909	16	14	and	and	CCONJ
admet-909	16	15	pharmacokinetic	pharmacokinetic	ADJ
admet-909	16	16	parameters	parameter	NOUN
admet-909	16	17	of	of	ADP
admet-909	16	18	warfarin	warfarin	NOUN
admet-909	16	19	.	.	PUNCT
admet-909	17	1	©	©	PROPN
admet-909	17	2	2021	2021	NUM
admet-909	17	3	by	by	ADP
admet-909	17	4	the	the	DET
admet-909	17	5	authors	author	NOUN
admet-909	17	6	.	.	PUNCT
admet-909	18	1	this	this	DET
admet-909	18	2	article	article	NOUN
admet-909	18	3	is	be	AUX
admet-909	18	4	an	an	DET
admet-909	18	5	open	open	ADJ
admet-909	18	6	-	-	PUNCT
admet-909	18	7	access	access	NOUN
admet-909	18	8	article	article	NOUN
admet-909	18	9	distributed	distribute	VERB
admet-909	18	10	under	under	ADP
admet-909	18	11	the	the	DET
admet-909	18	12	terms	term	NOUN
admet-909	18	13	and	and	CCONJ
admet-909	18	14	conditions	condition	NOUN
admet-909	18	15	of	of	ADP
admet-909	18	16	the	the	DET
admet-909	18	17	creative	creative	ADJ
admet-909	18	18	commons	common	NOUN
admet-909	18	19	attribution	attribution	NOUN
admet-909	18	20	license	license	NOUN
admet-909	18	21	(	(	PUNCT
admet-909	18	22	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-909	18	23	)	)	PUNCT
admet-909	18	24	.	.	PUNCT
admet-909	19	1	keywords	keyword	VERB
admet-909	19	2	pharmacokinetics	pharmacokinetic	NOUN
admet-909	19	3	;	;	PUNCT
admet-909	19	4	warfarin	warfarin	NOUN
admet-909	19	5	;	;	PUNCT
admet-909	19	6	anticoagulant	anticoagulant	ADJ
admet-909	19	7	introduction	introduction	NOUN
admet-909	19	8	warfarin	warfarin	NOUN
admet-909	19	9	,	,	PUNCT
admet-909	19	10	an	an	DET
admet-909	19	11	oral	oral	ADJ
admet-909	19	12	anticoagulant	anticoagulant	NOUN
admet-909	19	13	,	,	PUNCT
admet-909	19	14	exhibits	exhibit	VERB
admet-909	19	15	narrow	narrow	ADJ
admet-909	19	16	therapeutic	therapeutic	ADJ
admet-909	19	17	window	window	NOUN
admet-909	19	18	and	and	CCONJ
admet-909	19	19	poses	pose	VERB
admet-909	19	20	clinical	clinical	ADJ
admet-909	19	21	challenges	challenge	NOUN
admet-909	19	22	in	in	ADP
admet-909	19	23	maintaining	maintain	VERB
admet-909	19	24	appropriate	appropriate	ADJ
admet-909	19	25	therapeutic	therapeutic	ADJ
admet-909	19	26	effect	effect	NOUN
admet-909	19	27	.	.	PUNCT
admet-909	20	1	warfarin	warfarin	NOUN
admet-909	20	2	is	be	AUX
admet-909	20	3	metabolized	metabolize	VERB
admet-909	20	4	in	in	ADP
admet-909	20	5	liver	liver	NOUN
admet-909	20	6	and	and	CCONJ
admet-909	20	7	its	its	PRON
admet-909	20	8	anticoagulant	anticoagulant	ADJ
admet-909	20	9	effect	effect	NOUN
admet-909	20	10	is	be	AUX
admet-909	20	11	considered	consider	VERB
admet-909	20	12	optimum	optimum	ADJ
admet-909	20	13	when	when	SCONJ
admet-909	20	14	the	the	DET
admet-909	20	15	prothrombin	prothrombin	ADJ
admet-909	20	16	time	time	NOUN
admet-909	20	17	international	international	PROPN
admet-909	20	18	normalized	normalize	VERB
admet-909	20	19	ratio	ratio	NOUN
admet-909	20	20	(	(	PUNCT
admet-909	20	21	pt	pt	PROPN
admet-909	20	22	-	-	PUNCT
admet-909	20	23	inr	inr	NOUN
admet-909	20	24	)	)	PUNCT
admet-909	20	25	is	be	AUX
admet-909	20	26	to	to	PART
admet-909	20	27	be	be	AUX
admet-909	20	28	maintained	maintain	VERB
admet-909	20	29	between	between	ADP
admet-909	20	30	2.5	2.5	NUM
admet-909	20	31	and	and	CCONJ
admet-909	20	32	3.5	3.5	NUM
admet-909	20	33	for	for	ADP
admet-909	20	34	those	those	PRON
admet-909	20	35	undergoing	undergo	VERB
admet-909	20	36	heart	heart	NOUN
admet-909	20	37	valve	valve	NOUN
admet-909	20	38	replacements	replacement	NOUN
admet-909	20	39	and	and	CCONJ
admet-909	20	40	between	between	ADP
admet-909	20	41	2	2	NUM
admet-909	20	42	and	and	CCONJ
admet-909	20	43	3	3	NUM
admet-909	20	44	for	for	ADP
admet-909	20	45	others	other	NOUN
admet-909	21	1	[	[	X
admet-909	21	2	1	1	NUM
admet-909	21	3	]	]	PUNCT
admet-909	21	4	.	.	PUNCT
admet-909	22	1	warfarin	warfarin	NOUN
admet-909	22	2	is	be	AUX
admet-909	22	3	completely	completely	ADV
admet-909	22	4	absorbed	absorb	VERB
admet-909	22	5	with	with	ADP
admet-909	22	6	time	time	NOUN
admet-909	22	7	to	to	ADP
admet-909	22	8	maximum	maximum	ADJ
admet-909	22	9	concentration	concentration	NOUN
admet-909	22	10	of	of	ADP
admet-909	22	11	2	2	NUM
admet-909	22	12	-	-	SYM
admet-909	22	13	6	6	NUM
admet-909	22	14	hours	hour	NOUN
admet-909	22	15	;	;	PUNCT
admet-909	22	16	volume	volume	NOUN
admet-909	22	17	of	of	ADP
admet-909	22	18	distribution	distribution	NOUN
admet-909	22	19	(	(	PUNCT
admet-909	22	20	vd	vd	NOUN
admet-909	22	21	)	)	PUNCT
admet-909	22	22	of	of	ADP
admet-909	22	23	10	10	NUM
admet-909	22	24	l	l	NOUN
admet-909	22	25	;	;	PUNCT
admet-909	22	26	clearance	clearance	NOUN
admet-909	22	27	(	(	PUNCT
admet-909	22	28	cl	cl	NOUN
admet-909	22	29	)	)	PUNCT
admet-909	22	30	of	of	ADP
admet-909	22	31	0.2	0.2	NUM
admet-909	22	32	https://dx.doi.org/10.5599/admet.909	https://dx.doi.org/10.5599/admet.909	ADJ
admet-909	22	33	https://doi.org/10.5599/admet.909	https://doi.org/10.5599/admet.909	ADJ
admet-909	22	34	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-909	22	35	mailto:skannandr@gmail.com	mailto:skannandr@gmail.com	X
admet-909	23	1	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-909	23	2	k.	k.	PROPN
admet-909	23	3	sridharan	sridharan	PROPN
admet-909	23	4	et	et	PROPN
admet-909	23	5	al	al	PROPN
admet-909	23	6	.	.	PROPN
admet-909	23	7	admet	admet	PROPN
admet-909	23	8	&	&	CCONJ
admet-909	23	9	dmpk	dmpk	PROPN
admet-909	23	10	9(2	9(2	NUM
admet-909	23	11	)	)	PUNCT
admet-909	23	12	(	(	PUNCT
admet-909	23	13	2021	2021	NUM
admet-909	23	14	)	)	PUNCT
admet-909	23	15	143	143	NUM
admet-909	23	16	-	-	SYM
admet-909	23	17	149	149	NUM
admet-909	23	18	144	144	NUM
admet-909	23	19	l	l	NOUN
admet-909	23	20	/	/	SYM
admet-909	23	21	hour	hour	NOUN
admet-909	23	22	;	;	PUNCT
admet-909	23	23	and	and	CCONJ
admet-909	23	24	elimination	elimination	NOUN
admet-909	23	25	half	half	ADJ
admet-909	23	26	-	-	PUNCT
admet-909	23	27	life	life	NOUN
admet-909	23	28	of	of	ADP
admet-909	23	29	35	35	NUM
admet-909	23	30	hours	hour	NOUN
admet-909	24	1	[	[	X
admet-909	24	2	2	2	NUM
admet-909	24	3	]	]	PUNCT
admet-909	24	4	.	.	PUNCT
admet-909	25	1	warfarin	warfarin	NOUN
admet-909	25	2	is	be	AUX
admet-909	25	3	a	a	DET
admet-909	25	4	racemic	racemic	ADJ
admet-909	25	5	mixture	mixture	NOUN
admet-909	25	6	of	of	ADP
admet-909	25	7	sand	sand	NOUN
admet-909	25	8	r	r	NOUN
admet-909	25	9	-	-	PUNCT
admet-909	25	10	warfarin	warfarin	NOUN
admet-909	25	11	posing	pose	VERB
admet-909	25	12	challenges	challenge	NOUN
admet-909	25	13	in	in	ADP
admet-909	25	14	measurements	measurement	NOUN
admet-909	25	15	[	[	X
admet-909	25	16	3	3	NUM
admet-909	25	17	]	]	PUNCT
admet-909	25	18	.	.	PUNCT
admet-909	26	1	pharmacokinetic	pharmacokinetic	ADJ
admet-909	26	2	-	-	PUNCT
admet-909	26	3	pharmacodynamic	pharmacodynamic	ADJ
admet-909	26	4	(	(	PUNCT
admet-909	26	5	pk	pk	NOUN
admet-909	26	6	-	-	PUNCT
admet-909	26	7	pd	pd	NOUN
admet-909	26	8	)	)	PUNCT
admet-909	26	9	relationship	relationship	NOUN
admet-909	26	10	of	of	ADP
admet-909	26	11	warfarin	warfarin	NOUN
admet-909	26	12	has	have	AUX
admet-909	26	13	been	be	AUX
admet-909	26	14	well	well	ADV
admet-909	26	15	elucidated	elucidated	ADJ
admet-909	26	16	and	and	CCONJ
admet-909	26	17	therapeutic	therapeutic	ADJ
admet-909	26	18	drug	drug	NOUN
admet-909	26	19	monitoring	monitoring	NOUN
admet-909	26	20	is	be	AUX
admet-909	26	21	carried	carry	VERB
admet-909	26	22	out	out	ADP
admet-909	26	23	by	by	ADP
admet-909	26	24	pt	pt	PROPN
admet-909	26	25	-	-	PUNCT
admet-909	26	26	inr	inr	NOUN
admet-909	26	27	measurement	measurement	NOUN
admet-909	26	28	[	[	X
admet-909	26	29	4	4	NUM
admet-909	26	30	]	]	PUNCT
admet-909	26	31	.	.	PUNCT
admet-909	27	1	warfarin	warfarin	NOUN
admet-909	27	2	pharmacokinetics	pharmacokinetic	NOUN
admet-909	27	3	has	have	AUX
admet-909	27	4	not	not	PART
admet-909	27	5	been	be	AUX
admet-909	27	6	described	describe	VERB
admet-909	27	7	in	in	ADP
admet-909	27	8	our	our	PRON
admet-909	27	9	population	population	NOUN
admet-909	27	10	.	.	PUNCT
admet-909	28	1	hence	hence	ADV
admet-909	28	2	,	,	PUNCT
admet-909	28	3	we	we	PRON
admet-909	28	4	carried	carry	VERB
admet-909	28	5	out	out	ADP
admet-909	28	6	the	the	DET
admet-909	28	7	present	present	ADJ
admet-909	28	8	study	study	NOUN
admet-909	28	9	to	to	PART
admet-909	28	10	predict	predict	VERB
admet-909	28	11	the	the	DET
admet-909	28	12	pharmacokinetic	pharmacokinetic	ADJ
admet-909	28	13	parameters	parameter	NOUN
admet-909	28	14	of	of	ADP
admet-909	28	15	warfarin	warfarin	NOUN
admet-909	28	16	from	from	ADP
admet-909	28	17	the	the	DET
admet-909	28	18	pharmacodynamic	pharmacodynamic	ADJ
admet-909	28	19	variables	variable	NOUN
admet-909	28	20	using	use	VERB
admet-909	28	21	a	a	DET
admet-909	28	22	validated	validate	VERB
admet-909	28	23	pd	pd	ADJ
admet-909	28	24	-	-	PUNCT
admet-909	28	25	pd	pd	PROPN
admet-909	28	26	model	model	NOUN
admet-909	28	27	.	.	PUNCT
admet-909	29	1	experimental	experimental	ADJ
admet-909	29	2	study	study	NOUN
admet-909	29	3	ethics	ethic	NOUN
admet-909	29	4	and	and	CCONJ
admet-909	29	5	design	design	VERB
admet-909	29	6	the	the	DET
admet-909	29	7	study	study	NOUN
admet-909	29	8	was	be	AUX
admet-909	29	9	retrospective	retrospective	ADJ
admet-909	29	10	carried	carry	VERB
admet-909	29	11	out	out	ADP
admet-909	29	12	as	as	ADP
admet-909	29	13	a	a	DET
admet-909	29	14	part	part	NOUN
admet-909	29	15	of	of	ADP
admet-909	29	16	warfarin	warfarin	NOUN
admet-909	29	17	pharmacogenomics	pharmacogenomic	NOUN
admet-909	29	18	study	study	VERB
admet-909	29	19	after	after	ADP
admet-909	29	20	obtaining	obtain	VERB
admet-909	29	21	approval	approval	NOUN
admet-909	29	22	from	from	ADP
admet-909	29	23	institutional	institutional	ADJ
admet-909	29	24	ethics	ethic	NOUN
admet-909	29	25	committee	committee	NOUN
admet-909	29	26	and	and	CCONJ
admet-909	29	27	consent	consent	NOUN
admet-909	29	28	from	from	ADP
admet-909	29	29	study	study	NOUN
admet-909	29	30	participants	participant	NOUN
admet-909	29	31	.	.	PUNCT
admet-909	30	1	the	the	DET
admet-909	30	2	present	present	ADJ
admet-909	30	3	study	study	NOUN
admet-909	30	4	complies	comply	VERB
admet-909	30	5	with	with	ADP
admet-909	30	6	the	the	DET
admet-909	30	7	latest	late	ADJ
admet-909	30	8	world	world	PROPN
admet-909	30	9	medical	medical	PROPN
admet-909	30	10	association	association	PROPN
admet-909	30	11	declaration	declaration	PROPN
admet-909	30	12	of	of	ADP
admet-909	30	13	helsinki	helsinki	PROPN
admet-909	30	14	guidelines	guidelines	PROPN
admet-909	30	15	.	.	PUNCT
admet-909	31	1	study	study	NOUN
admet-909	31	2	procedure	procedure	NOUN
admet-909	31	3	participants	participant	NOUN
admet-909	31	4	receiving	receive	VERB
admet-909	31	5	warfarin	warfarin	NOUN
admet-909	31	6	for	for	ADP
admet-909	31	7	at	at	ADV
admet-909	31	8	least	least	ADV
admet-909	31	9	6	6	NUM
admet-909	31	10	months	month	NOUN
admet-909	31	11	were	be	AUX
admet-909	31	12	recruited	recruit	VERB
admet-909	31	13	in	in	ADP
admet-909	31	14	the	the	DET
admet-909	31	15	present	present	ADJ
admet-909	31	16	study	study	NOUN
admet-909	31	17	.	.	PUNCT
admet-909	32	1	their	their	PRON
admet-909	32	2	demographics	demographic	NOUN
admet-909	32	3	,	,	PUNCT
admet-909	32	4	pt	pt	PROPN
admet-909	32	5	-	-	PUNCT
admet-909	32	6	inr	inr	NOUN
admet-909	32	7	values	value	NOUN
admet-909	32	8	,	,	PUNCT
admet-909	32	9	dose	dose	NOUN
admet-909	32	10	and	and	CCONJ
admet-909	32	11	frequency	frequency	NOUN
admet-909	32	12	of	of	ADP
admet-909	32	13	warfarin	warfarin	NOUN
admet-909	32	14	,	,	PUNCT
admet-909	32	15	and	and	CCONJ
admet-909	32	16	concomitant	concomitant	ADJ
admet-909	32	17	drugs	drug	NOUN
admet-909	32	18	were	be	AUX
admet-909	32	19	obtained	obtain	VERB
admet-909	32	20	.	.	PUNCT
admet-909	33	1	we	we	PRON
admet-909	33	2	assessed	assess	VERB
admet-909	33	3	cha₂ds₂-vasc	cha₂ds₂-vasc	NOUN
admet-909	33	4	,	,	PUNCT
admet-909	33	5	hasbled	hasbled	ADJ
admet-909	33	6	and	and	CCONJ
admet-909	33	7	same	same	ADJ
admet-909	33	8	-	-	PUNCT
admet-909	33	9	tt2r2	tt2r2	NOUN
admet-909	33	10	scores	score	NOUN
admet-909	33	11	for	for	ADP
admet-909	33	12	the	the	DET
admet-909	33	13	study	study	NOUN
admet-909	33	14	participants	participant	NOUN
admet-909	33	15	[	[	X
admet-909	33	16	5,6	5,6	NUM
admet-909	33	17	]	]	PUNCT
admet-909	33	18	.	.	PUNCT
admet-909	34	1	drugs	drug	NOUN
admet-909	34	2	/	/	SYM
admet-909	34	3	drug	drug	NOUN
admet-909	34	4	classes	class	NOUN
admet-909	34	5	such	such	ADJ
admet-909	34	6	as	as	ADP
admet-909	34	7	statins	statin	NOUN
admet-909	34	8	,	,	PUNCT
admet-909	34	9	proton	proton	NOUN
admet-909	34	10	pump	pump	NOUN
admet-909	34	11	inhibitors	inhibitor	NOUN
admet-909	34	12	,	,	PUNCT
admet-909	34	13	carbamazepine	carbamazepine	NOUN
admet-909	34	14	and	and	CCONJ
admet-909	34	15	amiodarone	amiodarone	PROPN
admet-909	34	16	were	be	AUX
admet-909	34	17	categorized	categorize	VERB
admet-909	34	18	as	as	ADP
admet-909	34	19	drugs	drug	NOUN
admet-909	34	20	with	with	ADP
admet-909	34	21	potential	potential	ADJ
admet-909	34	22	interaction	interaction	NOUN
admet-909	34	23	with	with	ADP
admet-909	34	24	warfarin	warfarin	NOUN
admet-909	34	25	[	[	X
admet-909	34	26	7	7	NUM
admet-909	34	27	]	]	PUNCT
admet-909	34	28	.	.	PUNCT
admet-909	35	1	we	we	PRON
admet-909	35	2	followed	follow	VERB
admet-909	35	3	national	national	PROPN
admet-909	35	4	institute	institute	PROPN
admet-909	35	5	for	for	ADP
admet-909	35	6	health	health	NOUN
admet-909	35	7	and	and	CCONJ
admet-909	35	8	care	care	PROPN
admet-909	35	9	excellence	excellence	PROPN
admet-909	35	10	(	(	PUNCT
admet-909	35	11	nice	nice	ADJ
admet-909	35	12	)	)	PUNCT
admet-909	35	13	guidelines	guideline	NOUN
admet-909	35	14	for	for	ADP
admet-909	35	15	classifying	classify	VERB
admet-909	35	16	anticoagulation	anticoagulation	NOUN
admet-909	35	17	control	control	NOUN
admet-909	35	18	into	into	ADP
admet-909	35	19	good	good	ADJ
admet-909	35	20	(	(	PUNCT
admet-909	35	21	ttr	ttr	X
admet-909	35	22	≥	≥	NUM
admet-909	35	23	65	65	NUM
admet-909	35	24	%	%	NOUN
admet-909	35	25	)	)	PUNCT
admet-909	35	26	and	and	CCONJ
admet-909	35	27	poor	poor	ADJ
admet-909	35	28	(	(	PUNCT
admet-909	35	29	ttr	ttr	X
admet-909	35	30	<	<	X
admet-909	35	31	65	65	NUM
admet-909	35	32	%	%	NOUN
admet-909	35	33	)	)	PUNCT
admet-909	36	1	[	[	X
admet-909	36	2	8	8	NUM
admet-909	36	3	]	]	PUNCT
admet-909	36	4	.	.	PUNCT
admet-909	37	1	we	we	PRON
admet-909	37	2	estimated	estimate	VERB
admet-909	37	3	warfarin	warfarin	NOUN
admet-909	37	4	sensitive	sensitive	ADJ
admet-909	37	5	index	index	NOUN
admet-909	37	6	(	(	PUNCT
admet-909	37	7	wsi	wsi	PROPN
admet-909	37	8	)	)	PUNCT
admet-909	37	9	based	base	VERB
admet-909	37	10	on	on	ADP
admet-909	37	11	the	the	DET
admet-909	37	12	ratio	ratio	NOUN
admet-909	37	13	of	of	ADP
admet-909	37	14	pt	pt	PROPN
admet-909	37	15	-	-	PUNCT
admet-909	37	16	inr	inr	NOUN
admet-909	37	17	upon	upon	SCONJ
admet-909	37	18	the	the	DET
admet-909	37	19	last	last	ADJ
admet-909	37	20	dose	dose	NOUN
admet-909	37	21	of	of	ADP
admet-909	37	22	warfarin	warfarin	NOUN
admet-909	37	23	[	[	X
admet-909	37	24	9	9	NUM
admet-909	37	25	]	]	PUNCT
admet-909	37	26	.	.	PUNCT
admet-909	38	1	we	we	PRON
admet-909	38	2	assessed	assess	VERB
admet-909	38	3	the	the	DET
admet-909	38	4	difference	difference	NOUN
admet-909	38	5	in	in	ADP
admet-909	38	6	pt	pt	PROPN
admet-909	38	7	-	-	PUNCT
admet-909	38	8	inr	inr	NOUN
admet-909	38	9	between	between	ADP
admet-909	38	10	the	the	DET
admet-909	38	11	two	two	NUM
admet-909	38	12	consequent	consequent	ADJ
admet-909	38	13	visits	visit	NOUN
admet-909	38	14	that	that	PRON
admet-909	38	15	was	be	AUX
admet-909	38	16	squared	square	VERB
admet-909	38	17	and	and	CCONJ
admet-909	38	18	divided	divide	VERB
admet-909	38	19	by	by	ADP
admet-909	38	20	the	the	DET
admet-909	38	21	time	time	NOUN
admet-909	38	22	interval	interval	NOUN
admet-909	38	23	in	in	ADP
admet-909	38	24	days	day	NOUN
admet-909	38	25	.	.	PUNCT
admet-909	39	1	this	this	DET
admet-909	39	2	cross	cross	NOUN
admet-909	39	3	product	product	NOUN
admet-909	39	4	with	with	ADP
admet-909	39	5	the	the	DET
admet-909	39	6	average	average	NOUN
admet-909	39	7	of	of	ADP
admet-909	39	8	pt	pt	NOUN
admet-909	39	9	-	-	PUNCT
admet-909	39	10	inr	inr	NOUN
admet-909	39	11	on	on	ADP
admet-909	39	12	the	the	DET
admet-909	39	13	visits	visit	NOUN
admet-909	39	14	followed	follow	VERB
admet-909	39	15	by	by	ADP
admet-909	39	16	square	square	ADJ
admet-909	39	17	root	root	NOUN
admet-909	39	18	of	of	ADP
admet-909	39	19	this	this	DET
admet-909	39	20	product	product	NOUN
admet-909	39	21	provided	provide	VERB
admet-909	39	22	the	the	DET
admet-909	39	23	inr	inr	PROPN
admet-909	39	24	variability	variability	NOUN
admet-909	39	25	.	.	PUNCT
admet-909	40	1	we	we	PRON
admet-909	40	2	log	log	NOUN
admet-909	40	3	-	-	PUNCT
admet-909	40	4	transformed	transform	VERB
admet-909	40	5	it	it	PRON
admet-909	40	6	to	to	PART
admet-909	40	7	base	base	VERB
admet-909	40	8	10	10	NUM
admet-909	40	9	to	to	PART
admet-909	40	10	obtain	obtain	VERB
admet-909	40	11	log	log	NOUN
admet-909	40	12	-	-	PUNCT
admet-909	40	13	inr	inr	NOUN
admet-909	40	14	variability	variability	NOUN
admet-909	40	15	[	[	X
admet-909	40	16	10	10	NUM
admet-909	40	17	]	]	PUNCT
admet-909	40	18	.	.	PUNCT
admet-909	41	1	standardized	standardize	VERB
admet-909	41	2	z	z	NOUN
admet-909	41	3	scores	score	NOUN
admet-909	41	4	were	be	AUX
admet-909	41	5	obtained	obtain	VERB
admet-909	41	6	for	for	ADP
admet-909	41	7	ttr	ttr	PROPN
admet-909	41	8	and	and	CCONJ
admet-909	41	9	log	log	PROPN
admet-909	41	10	-	-	PUNCT
admet-909	41	11	inr	inr	NOUN
admet-909	41	12	variability	variability	NOUN
admet-909	41	13	and	and	CCONJ
admet-909	41	14	warfarin	warfarin	NOUN
admet-909	41	15	composite	composite	ADJ
admet-909	41	16	measure	measure	NOUN
admet-909	41	17	(	(	PUNCT
admet-909	41	18	wcm	wcm	NOUN
admet-909	41	19	)	)	PUNCT
admet-909	41	20	was	be	AUX
admet-909	41	21	estimated	estimate	VERB
admet-909	41	22	[	[	X
admet-909	41	23	11	11	NUM
admet-909	41	24	]	]	PUNCT
admet-909	41	25	.	.	PUNCT
admet-909	42	1	liver	liver	NOUN
admet-909	42	2	weight	weight	NOUN
admet-909	42	3	was	be	AUX
admet-909	42	4	estimated	estimate	VERB
admet-909	42	5	by	by	ADP
admet-909	42	6	using	use	VERB
admet-909	42	7	the	the	DET
admet-909	42	8	validated	validate	VERB
admet-909	42	9	formula	formula	NOUN
admet-909	42	10	:	:	PUNCT
admet-909	42	11	liver	liver	NOUN
admet-909	42	12	weight	weight	NOUN
admet-909	42	13	(	(	PUNCT
admet-909	42	14	g	g	NOUN
admet-909	42	15	)	)	PUNCT
admet-909	42	16	=	=	SYM
admet-909	42	17	218	218	NUM
admet-909	42	18	+	+	NUM
admet-909	42	19	body	body	NOUN
admet-909	42	20	weight	weight	NOUN
admet-909	42	21	(	(	PUNCT
admet-909	42	22	kg	kg	X
admet-909	42	23	)	)	PUNCT
admet-909	42	24	*	*	PUNCT
admet-909	43	1	12.3	12.3	NUM
admet-909	43	2	+	+	NUM
admet-909	43	3	gender	gender	NOUN
admet-909	43	4	*	*	PUNCT
admet-909	43	5	51	51	NUM
admet-909	43	6	(	(	PUNCT
admet-909	43	7	male-1	male-1	NUM
admet-909	43	8	;	;	PUNCT
admet-909	43	9	female-0	female-0	NUM
admet-909	43	10	)	)	PUNCT
admet-909	44	1	[	[	X
admet-909	44	2	12	12	NUM
admet-909	44	3	]	]	PUNCT
admet-909	44	4	.	.	PUNCT
admet-909	45	1	predicted	predict	VERB
admet-909	45	2	pharmacokinetic	pharmacokinetic	ADJ
admet-909	45	3	parameters	parameter	NOUN
admet-909	45	4	we	we	PRON
admet-909	45	5	used	use	VERB
admet-909	45	6	jpkd	jpkd	ADJ
admet-909	45	7	software	software	NOUN
admet-909	45	8	©	©	PROPN
admet-909	45	9	for	for	ADP
admet-909	45	10	estimating	estimate	VERB
admet-909	45	11	pharmacokinetic	pharmacokinetic	ADJ
admet-909	45	12	parameters	parameter	NOUN
admet-909	45	13	of	of	ADP
admet-909	45	14	warfarin	warfarin	NOUN
admet-909	45	15	from	from	ADP
admet-909	45	16	the	the	DET
admet-909	45	17	validated	validate	VERB
admet-909	45	18	warfarin	warfarin	NOUN
admet-909	45	19	pd	pd	PROPN
admet-909	45	20	-	-	PUNCT
admet-909	45	21	pd	pd	ADJ
admet-909	45	22	inbuilt	inbuilt	ADJ
admet-909	45	23	model	model	NOUN
admet-909	45	24	[	[	X
admet-909	45	25	13	13	NUM
admet-909	45	26	]	]	PUNCT
admet-909	45	27	.	.	PUNCT
admet-909	46	1	the	the	DET
admet-909	46	2	following	follow	VERB
admet-909	46	3	equations	equation	NOUN
admet-909	46	4	were	be	AUX
admet-909	46	5	input	input	ADJ
admet-909	46	6	in	in	ADP
admet-909	46	7	the	the	DET
admet-909	46	8	model	model	NOUN
admet-909	46	9	:	:	PUNCT
admet-909	46	10	cs	cs	PROPN
admet-909	46	11	=	=	SYM
admet-909	46	12	(	(	PUNCT
admet-909	46	13	(	(	PUNCT
admet-909	46	14	1/(-(m*cl	1/(-(m*cl	NUM
admet-909	46	15	/	/	SYM
admet-909	46	16	v)/(k^2)*(1-(k*tau/24)/(1	v)/(k^2)*(1-(k*tau/24)/(1	NOUN
admet-909	46	17	-	-	PUNCT
admet-909	46	18	exp(-k*tau/24)))-(m	exp(-k*tau/24)))-(m	NOUN
admet-909	46	19	/	/	SYM
admet-909	46	20	k)*ln((dose	k)*ln((dose	PROPN
admet-909	46	21	/	/	SYM
admet-909	46	22	v)/(cmax*(1	v)/(cmax*(1	NOUN
admet-909	46	23	-	-	PUNCT
admet-909	46	24	exp((cl	exp((cl	PROPN
admet-909	46	25	/	/	SYM
admet-909	46	26	v)*(tau/24))))))+3.36)/4.368)^(1/0.383	v)*(tau/24))))))+3.36)/4.368)^(1/0.383	PROPN
admet-909	46	27	)	)	PUNCT
admet-909	46	28	inr	inr	NOUN
admet-909	46	29	=	=	PUNCT
admet-909	46	30	(	(	PUNCT
admet-909	46	31	(	(	PUNCT
admet-909	46	32	1/(-(m*cl	1/(-(m*cl	NUM
admet-909	46	33	/	/	SYM
admet-909	46	34	v)/(k^2)*(1-(k*tau/24)/(1	v)/(k^2)*(1-(k*tau/24)/(1	NOUN
admet-909	46	35	-	-	PUNCT
admet-909	46	36	exp(-k*tau/24)))-(m	exp(-k*tau/24)))-(m	NOUN
admet-909	46	37	/	/	SYM
admet-909	46	38	k)*ln((dose	k)*ln((dose	PROPN
admet-909	46	39	/	/	SYM
admet-909	46	40	v)/(cmax*(1	v)/(cmax*(1	NOUN
admet-909	46	41	-	-	PUNCT
admet-909	46	42	exp((cl	exp((cl	PROPN
admet-909	46	43	/	/	SYM
admet-909	46	44	v)*(tau/24))))))+3.36)/4.368)^(1/0.383	v)*(tau/24))))))+3.36)/4.368)^(1/0.383	PROPN
admet-909	46	45	)	)	PUNCT
admet-909	46	46	dose	dose	NOUN
admet-909	46	47	=	=	PROPN
admet-909	46	48	exp((1+((m*cl	exp((1+((m*cl	PROPN
admet-909	46	49	/	/	SYM
admet-909	46	50	v)/k^2)*(1-(k*tau/24)/(1	v)/k^2)*(1-(k*tau/24)/(1	PROPN
admet-909	46	51	-	-	PUNCT
admet-909	46	52	exp(-k*tau/24)))*(4.368*inr^(0.383)-3.36))/((m	exp(-k*tau/24)))*(4.368*inr^(0.383)-3.36))/((m	ADV
admet-909	46	53	/	/	SYM
admet-909	46	54	k)*(4.368*inr^(0.383)-3.36	k)*(4.368*inr^(0.383)-3.36	PROPN
admet-909	46	55	)	)	PUNCT
admet-909	46	56	)	)	PUNCT
admet-909	46	57	)	)	PUNCT
admet-909	47	1	*	*	PUNCT
admet-909	47	2	cmax	cmax	NOUN
admet-909	47	3	*	*	PUNCT
admet-909	47	4	(	(	PUNCT
admet-909	47	5	1	1	NUM
admet-909	47	6	-	-	PUNCT
admet-909	47	7	exp((-cl	exp((-cl	NOUN
admet-909	47	8	/	/	SYM
admet-909	47	9	v)*tau/24))*v	v)*tau/24))*v	NOUN
admet-909	47	10	statistical	statistical	ADJ
admet-909	47	11	analysis	analysis	NOUN
admet-909	47	12	we	we	PRON
admet-909	47	13	represented	represent	VERB
admet-909	47	14	the	the	DET
admet-909	47	15	demographic	demographic	ADJ
admet-909	47	16	details	detail	NOUN
admet-909	47	17	using	use	VERB
admet-909	47	18	descriptive	descriptive	ADJ
admet-909	47	19	statistics	statistic	NOUN
admet-909	47	20	.	.	PUNCT
admet-909	48	1	chi	chi	ADJ
admet-909	48	2	-	-	PUNCT
admet-909	48	3	square	square	ADJ
admet-909	48	4	test	test	NOUN
admet-909	48	5	for	for	ADP
admet-909	48	6	association	association	NOUN
admet-909	48	7	was	be	AUX
admet-909	48	8	used	use	VERB
admet-909	48	9	for	for	ADP
admet-909	48	10	assessing	assess	VERB
admet-909	48	11	the	the	DET
admet-909	48	12	categorical	categorical	ADJ
admet-909	48	13	variables	variable	NOUN
admet-909	48	14	.	.	PUNCT
admet-909	49	1	numerical	numerical	ADJ
admet-909	49	2	variables	variable	NOUN
admet-909	49	3	following	follow	VERB
admet-909	49	4	the	the	DET
admet-909	49	5	assessment	assessment	NOUN
admet-909	49	6	of	of	ADP
admet-909	49	7	their	their	PRON
admet-909	49	8	distributions	distribution	NOUN
admet-909	49	9	were	be	AUX
admet-909	49	10	tested	test	VERB
admet-909	49	11	using	use	VERB
admet-909	49	12	mann	mann	PROPN
admet-909	49	13	-	-	PUNCT
admet-909	49	14	whitney	whitney	PROPN
admet-909	49	15	u	u	PROPN
admet-909	49	16	test	test	NOUN
admet-909	49	17	.	.	PUNCT
admet-909	50	1	correlations	correlation	NOUN
admet-909	50	2	between	between	ADP
admet-909	50	3	the	the	DET
admet-909	50	4	variables	variable	NOUN
admet-909	50	5	were	be	AUX
admet-909	50	6	tested	test	VERB
admet-909	50	7	using	use	VERB
admet-909	50	8	pearson	pearson	NOUN
admet-909	50	9	correlation	correlation	NOUN
admet-909	50	10	tests	test	NOUN
admet-909	50	11	.	.	PUNCT
admet-909	51	1	a	a	DET
admet-909	51	2	p	p	NOUN
admet-909	51	3	-	-	PUNCT
admet-909	51	4	value	value	NOUN
admet-909	51	5	of	of	ADP
admet-909	51	6	<	<	X
admet-909	51	7	0.05	0.05	NUM
admet-909	51	8	was	be	AUX
admet-909	51	9	considered	consider	VERB
admet-909	51	10	significant	significant	ADJ
admet-909	51	11	.	.	PUNCT
admet-909	52	1	spss	spss	PROPN
admet-909	52	2	version	version	PROPN
admet-909	52	3	26	26	NUM
admet-909	52	4	(	(	PUNCT
admet-909	52	5	ibm	ibm	PROPN
admet-909	52	6	corp	corp	PROPN
admet-909	52	7	.	.	PROPN
admet-909	52	8	admet	admet	PROPN
admet-909	52	9	&	&	CCONJ
admet-909	52	10	dmpk	dmpk	PROPN
admet-909	52	11	9(2	9(2	NUM
admet-909	52	12	)	)	PUNCT
admet-909	52	13	(	(	PUNCT
admet-909	52	14	2021	2021	NUM
admet-909	52	15	)	)	PUNCT
admet-909	52	16	143	143	NUM
admet-909	52	17	-	-	SYM
admet-909	52	18	149	149	NUM
admet-909	52	19	warfarin	warfarin	NOUN
admet-909	52	20	pharmacokinetics	pharmacokinetic	NOUN
admet-909	52	21	doi	doi	NOUN
admet-909	52	22	:	:	PUNCT
admet-909	52	23	https://dx.doi.org/10.5599/admet.909	https://dx.doi.org/10.5599/admet.909	PROPN
admet-909	52	24	145	145	NUM
admet-909	52	25	released	release	VERB
admet-909	52	26	2019	2019	NUM
admet-909	52	27	.	.	PUNCT
admet-909	53	1	ibm	ibm	PROPN
admet-909	53	2	spss	spss	PROPN
admet-909	53	3	statistics	statistic	NOUN
admet-909	53	4	for	for	ADP
admet-909	53	5	windows	window	NOUN
admet-909	53	6	,	,	PUNCT
admet-909	53	7	version	version	NOUN
admet-909	53	8	26.0	26.0	NUM
admet-909	53	9	.	.	PUNCT
admet-909	54	1	armonk	armonk	PROPN
admet-909	54	2	,	,	PUNCT
admet-909	54	3	ny	ny	PROPN
admet-909	54	4	:	:	PROPN
admet-909	54	5	ibm	ibm	PROPN
admet-909	54	6	corp	corp	PROPN
admet-909	54	7	.	.	PROPN
admet-909	54	8	)	)	PUNCT
admet-909	54	9	was	be	AUX
admet-909	54	10	used	use	VERB
admet-909	54	11	for	for	ADP
admet-909	54	12	statistical	statistical	ADJ
admet-909	54	13	analysis	analysis	NOUN
admet-909	54	14	.	.	PUNCT
admet-909	55	1	normal	normal	ADJ
admet-909	55	2	distributions	distribution	NOUN
admet-909	55	3	were	be	AUX
admet-909	55	4	created	create	VERB
admet-909	55	5	for	for	ADP
admet-909	55	6	each	each	PRON
admet-909	55	7	of	of	ADP
admet-909	55	8	the	the	DET
admet-909	55	9	key	key	ADJ
admet-909	55	10	pharmacokinetic	pharmacokinetic	ADJ
admet-909	55	11	parameters	parameter	NOUN
admet-909	55	12	and	and	CCONJ
admet-909	55	13	characteristics	characteristic	NOUN
admet-909	55	14	were	be	AUX
admet-909	55	15	compared	compare	VERB
admet-909	55	16	between	between	ADP
admet-909	55	17	those	those	PRON
admet-909	55	18	with	with	ADP
admet-909	55	19	values	value	NOUN
admet-909	55	20	within	within	ADP
admet-909	55	21	mean+1.96	mean+1.96	PROPN
admet-909	55	22	sd	sd	NOUN
admet-909	55	23	and	and	CCONJ
admet-909	55	24	those	those	PRON
admet-909	55	25	outside	outside	ADP
admet-909	55	26	this	this	DET
admet-909	55	27	range	range	NOUN
admet-909	55	28	.	.	PUNCT
admet-909	56	1	results	result	VERB
admet-909	56	2	demographics	demographic	NOUN
admet-909	56	3	two	two	NUM
admet-909	56	4	-	-	PUNCT
admet-909	56	5	hundred	hundred	NUM
admet-909	56	6	and	and	CCONJ
admet-909	56	7	twenty	twenty	NUM
admet-909	56	8	patients	patient	NOUN
admet-909	56	9	were	be	AUX
admet-909	56	10	enrolled	enrol	VERB
admet-909	56	11	in	in	ADP
admet-909	56	12	this	this	DET
admet-909	56	13	study	study	NOUN
admet-909	56	14	.	.	PUNCT
admet-909	57	1	their	their	PRON
admet-909	57	2	demographic	demographic	ADJ
admet-909	57	3	details	detail	NOUN
admet-909	57	4	are	be	AUX
admet-909	57	5	listed	list	VERB
admet-909	57	6	in	in	ADP
admet-909	57	7	table	table	NOUN
admet-909	57	8	1	1	NUM
admet-909	57	9	.	.	PUNCT
admet-909	58	1	the	the	DET
admet-909	58	2	concomitant	concomitant	ADJ
admet-909	58	3	diagnoses	diagnose	VERB
admet-909	58	4	in	in	ADP
admet-909	58	5	the	the	DET
admet-909	58	6	study	study	NOUN
admet-909	58	7	participants	participant	NOUN
admet-909	58	8	were	be	AUX
admet-909	58	9	as	as	SCONJ
admet-909	58	10	follows	follow	VERB
admet-909	58	11	:	:	PUNCT
admet-909	59	1	systemic	systemic	ADJ
admet-909	59	2	hypertension	hypertension	NOUN
admet-909	59	3	(	(	PUNCT
admet-909	59	4	n=130	n=130	NUM
admet-909	59	5	)	)	PUNCT
admet-909	59	6	,	,	PUNCT
admet-909	59	7	diabetes	diabetes	NOUN
admet-909	59	8	mellitus	mellitus	NOUN
admet-909	59	9	(	(	PUNCT
admet-909	59	10	n=98	n=98	PROPN
admet-909	59	11	)	)	PUNCT
admet-909	59	12	,	,	PUNCT
admet-909	59	13	atrial	atrial	ADJ
admet-909	59	14	fibrillation	fibrillation	NOUN
admet-909	59	15	(	(	PUNCT
admet-909	59	16	n=85	n=85	PROPN
admet-909	59	17	)	)	PUNCT
admet-909	59	18	,	,	PUNCT
admet-909	59	19	ischemic	ischemic	ADJ
admet-909	59	20	heart	heart	NOUN
admet-909	59	21	disease	disease	NOUN
admet-909	59	22	(	(	PUNCT
admet-909	59	23	n=55	n=55	ADV
admet-909	59	24	)	)	PUNCT
admet-909	59	25	,	,	PUNCT
admet-909	59	26	thyroid	thyroid	NOUN
admet-909	59	27	disorders	disorder	NOUN
admet-909	59	28	(	(	PUNCT
admet-909	59	29	n=24	n=24	PROPN
admet-909	59	30	)	)	PUNCT
admet-909	59	31	,	,	PUNCT
admet-909	59	32	congestive	congestive	ADJ
admet-909	59	33	cardiac	cardiac	ADJ
admet-909	59	34	failure	failure	NOUN
admet-909	59	35	(	(	PUNCT
admet-909	59	36	n=9	n=9	NOUN
admet-909	59	37	)	)	PUNCT
admet-909	59	38	and	and	CCONJ
admet-909	59	39	bronchial	bronchial	ADJ
admet-909	59	40	asthma	asthma	NOUN
admet-909	59	41	(	(	PUNCT
admet-909	59	42	n=15	n=15	NUM
admet-909	59	43	)	)	PUNCT
admet-909	59	44	.	.	PUNCT
admet-909	60	1	table	table	NOUN
admet-909	60	2	1	1	NUM
admet-909	60	3	.	.	PUNCT
admet-909	61	1	demographic	demographic	ADJ
admet-909	61	2	details	detail	NOUN
admet-909	61	3	of	of	ADP
admet-909	61	4	the	the	DET
admet-909	61	5	study	study	NOUN
admet-909	61	6	participants	participant	NOUN
admet-909	61	7	(	(	PUNCT
admet-909	61	8	n=220	n=220	ADJ
admet-909	61	9	)	)	PUNCT
admet-909	61	10	pharmacokinetic	pharmacokinetic	ADJ
admet-909	61	11	parameters	parameter	NOUN
admet-909	61	12	mean	mean	VERB
admet-909	61	13	(	(	PUNCT
admet-909	61	14	sd	sd	NOUN
admet-909	61	15	)	)	PUNCT
admet-909	61	16	cmax	cmax	NOUN
admet-909	61	17	(	(	PUNCT
admet-909	61	18	mg	mg	PROPN
admet-909	61	19	/	/	SYM
admet-909	61	20	l	l	NOUN
admet-909	61	21	)	)	PUNCT
admet-909	61	22	amongst	amongst	ADP
admet-909	61	23	the	the	DET
admet-909	61	24	study	study	NOUN
admet-909	61	25	participants	participant	NOUN
admet-909	61	26	was	be	AUX
admet-909	61	27	5.8	5.8	NUM
admet-909	61	28	(	(	PUNCT
admet-909	61	29	0.4	0.4	NUM
admet-909	61	30	)	)	PUNCT
admet-909	61	31	;	;	PUNCT
admet-909	61	32	elimination	elimination	NOUN
admet-909	61	33	rate	rate	NOUN
admet-909	61	34	(	(	PUNCT
admet-909	61	35	l	l	NOUN
admet-909	61	36	/	/	SYM
admet-909	61	37	day	day	NOUN
admet-909	61	38	)	)	PUNCT
admet-909	61	39	was	be	AUX
admet-909	61	40	1	1	NUM
admet-909	61	41	(	(	PUNCT
admet-909	61	42	0.1	0.1	NUM
admet-909	61	43	)	)	PUNCT
admet-909	61	44	;	;	PUNCT
admet-909	61	45	cl	cl	INTJ
admet-909	61	46	(	(	PUNCT
admet-909	61	47	l	l	NOUN
admet-909	61	48	/	/	SYM
admet-909	61	49	day	day	NOUN
admet-909	61	50	)	)	PUNCT
admet-909	61	51	was	be	AUX
admet-909	61	52	2.1	2.1	NUM
admet-909	61	53	(	(	PUNCT
admet-909	61	54	0.2	0.2	NUM
admet-909	61	55	)	)	PUNCT
admet-909	61	56	;	;	PUNCT
admet-909	61	57	and	and	CCONJ
admet-909	61	58	vd	vd	NOUN
admet-909	61	59	(	(	PUNCT
admet-909	61	60	l	l	NOUN
admet-909	61	61	)	)	PUNCT
admet-909	61	62	was	be	AUX
admet-909	61	63	7.6	7.6	NUM
admet-909	61	64	(	(	PUNCT
admet-909	61	65	0.2	0.2	NUM
admet-909	61	66	)	)	PUNCT
admet-909	61	67	.	.	PUNCT
admet-909	62	1	distributions	distribution	NOUN
admet-909	62	2	of	of	ADP
admet-909	62	3	the	the	DET
admet-909	62	4	pharmacokinetic	pharmacokinetic	ADJ
admet-909	62	5	parameters	parameter	NOUN
admet-909	62	6	are	be	AUX
admet-909	62	7	depicted	depict	VERB
admet-909	62	8	in	in	ADP
admet-909	62	9	figure	figure	NOUN
admet-909	62	10	1	1	NUM
admet-909	62	11	.	.	PUNCT
admet-909	63	1	nineteen	nineteen	NUM
admet-909	63	2	patients	patient	NOUN
admet-909	63	3	had	have	VERB
admet-909	63	4	their	their	PRON
admet-909	63	5	cmax	cmax	NOUN
admet-909	63	6	outside	outside	ADP
admet-909	63	7	the	the	DET
admet-909	63	8	mean+1.96	mean+1.96	PROPN
admet-909	63	9	sd	sd	NOUN
admet-909	63	10	and	and	CCONJ
admet-909	63	11	14	14	NUM
admet-909	63	12	had	have	VERB
admet-909	63	13	the	the	DET
admet-909	63	14	same	same	ADJ
admet-909	63	15	for	for	ADP
admet-909	63	16	elimination	elimination	NOUN
admet-909	63	17	rate	rate	NOUN
admet-909	63	18	.	.	PUNCT
admet-909	64	1	such	such	ADJ
admet-909	64	2	patients	patient	NOUN
admet-909	64	3	were	be	AUX
admet-909	64	4	observed	observe	VERB
admet-909	64	5	with	with	ADP
admet-909	64	6	significantly	significantly	ADV
admet-909	64	7	lower	low	ADJ
admet-909	64	8	wsi	wsi	NOUN
admet-909	64	9	and	and	CCONJ
admet-909	64	10	greater	great	ADJ
admet-909	64	11	wcm	wcm	NOUN
admet-909	64	12	(	(	PUNCT
admet-909	64	13	table	table	NOUN
admet-909	64	14	2	2	NUM
admet-909	64	15	)	)	PUNCT
admet-909	64	16	.	.	PUNCT
admet-909	65	1	for	for	ADP
admet-909	65	2	cl	cl	NOUN
admet-909	65	3	,	,	PUNCT
admet-909	65	4	two	two	NUM
admet-909	65	5	had	have	VERB
admet-909	65	6	their	their	PRON
admet-909	65	7	values	value	NOUN
admet-909	65	8	lower	low	ADJ
admet-909	65	9	than	than	ADP
admet-909	65	10	mean–1.96	mean–1.96	PROPN
admet-909	65	11	sd	sd	NOUN
admet-909	65	12	;	;	PUNCT
admet-909	65	13	and	and	CCONJ
admet-909	65	14	for	for	ADP
admet-909	65	15	vd	vd	NOUN
admet-909	65	16	,	,	PUNCT
admet-909	65	17	two	two	NUM
admet-909	65	18	had	have	VERB
admet-909	65	19	lower	low	ADJ
admet-909	65	20	than	than	ADP
admet-909	65	21	mean–2	mean–2	PROPN
admet-909	65	22	sd	sd	NOUN
admet-909	65	23	,	,	PUNCT
admet-909	65	24	and	and	CCONJ
admet-909	65	25	four	four	NUM
admet-909	65	26	more	more	ADJ
admet-909	65	27	than	than	ADP
admet-909	65	28	mean+2	mean+2	DET
admet-909	65	29	sd	sd	NOUN
admet-909	65	30	.	.	PUNCT
admet-909	66	1	due	due	ADP
admet-909	66	2	to	to	ADP
admet-909	66	3	the	the	DET
admet-909	66	4	number	number	NOUN
admet-909	66	5	constraints	constraint	NOUN
admet-909	66	6	,	,	PUNCT
admet-909	66	7	we	we	PRON
admet-909	66	8	could	could	AUX
admet-909	66	9	not	not	PART
admet-909	66	10	analyze	analyze	VERB
admet-909	66	11	the	the	DET
admet-909	66	12	differences	difference	NOUN
admet-909	66	13	in	in	ADP
admet-909	66	14	any	any	PRON
admet-909	66	15	of	of	ADP
admet-909	66	16	the	the	DET
admet-909	66	17	variables	variable	NOUN
admet-909	66	18	for	for	ADP
admet-909	66	19	cl	cl	NOUN
admet-909	66	20	and	and	CCONJ
admet-909	66	21	vd	vd	NOUN
admet-909	66	22	of	of	ADP
admet-909	66	23	warfarin	warfarin	NOUN
admet-909	66	24	.	.	PUNCT
admet-909	67	1	no	no	DET
admet-909	67	2	significant	significant	ADJ
admet-909	67	3	differences	difference	NOUN
admet-909	67	4	were	be	AUX
admet-909	67	5	observed	observe	VERB
admet-909	67	6	between	between	ADP
admet-909	67	7	the	the	DET
admet-909	67	8	predicted	predict	VERB
admet-909	67	9	pharmacokinetic	pharmacokinetic	ADJ
admet-909	67	10	parameters	parameter	NOUN
admet-909	67	11	across	across	ADP
admet-909	67	12	the	the	DET
admet-909	67	13	age	age	NOUN
admet-909	67	14	groups	group	NOUN
admet-909	67	15	(	(	PUNCT
admet-909	67	16	figure	figure	NOUN
admet-909	67	17	2	2	NUM
admet-909	67	18	)	)	PUNCT
admet-909	67	19	.	.	PUNCT
admet-909	68	1	similar	similar	ADJ
admet-909	68	2	values	value	NOUN
admet-909	68	3	were	be	AUX
admet-909	68	4	obtained	obtain	VERB
admet-909	68	5	for	for	ADP
admet-909	68	6	males	male	NOUN
admet-909	68	7	[	[	X
admet-909	68	8	cmax	cmax	NOUN
admet-909	68	9	(	(	PUNCT
admet-909	68	10	mg	mg	PROPN
admet-909	68	11	/	/	SYM
admet-909	68	12	l	l	NOUN
admet-909	68	13	–	–	PUNCT
admet-909	68	14	5.8	5.8	NUM
admet-909	68	15	(	(	PUNCT
admet-909	68	16	0.4	0.4	NUM
admet-909	68	17	)	)	PUNCT
admet-909	68	18	;	;	PUNCT
admet-909	68	19	k	k	X
admet-909	68	20	(	(	PUNCT
admet-909	68	21	per	per	ADP
admet-909	68	22	day	day	NOUN
admet-909	68	23	)	)	PUNCT
admet-909	68	24	–	–	PUNCT
admet-909	68	25	1	1	NUM
admet-909	68	26	(	(	PUNCT
admet-909	68	27	0.1	0.1	NUM
admet-909	68	28	)	)	PUNCT
admet-909	68	29	;	;	PUNCT
admet-909	69	1	cl	cl	INTJ
admet-909	69	2	(	(	PUNCT
admet-909	69	3	l	l	NOUN
admet-909	69	4	/	/	SYM
admet-909	69	5	day	day	NOUN
admet-909	69	6	)	)	PUNCT
admet-909	69	7	–	–	PUNCT
admet-909	69	8	2.1	2.1	NUM
admet-909	69	9	(	(	PUNCT
admet-909	69	10	0.2	0.2	NUM
admet-909	69	11	)	)	PUNCT
admet-909	69	12	;	;	PUNCT
admet-909	69	13	and	and	CCONJ
admet-909	69	14	vd	vd	NOUN
admet-909	69	15	(	(	PUNCT
admet-909	69	16	l	l	NOUN
admet-909	69	17	)	)	PUNCT
admet-909	69	18	–	–	PUNCT
admet-909	69	19	7.6	7.6	NUM
admet-909	69	20	(	(	PUNCT
admet-909	69	21	0.2	0.2	NUM
admet-909	69	22	)	)	PUNCT
admet-909	69	23	]	]	PUNCT
admet-909	69	24	and	and	CCONJ
admet-909	69	25	females	female	NOUN
admet-909	70	1	[	[	X
admet-909	70	2	cmax	cmax	NOUN
admet-909	70	3	(	(	PUNCT
admet-909	70	4	mg	mg	PROPN
admet-909	70	5	/	/	SYM
admet-909	70	6	l	l	NOUN
admet-909	70	7	–	–	PUNCT
admet-909	70	8	5.8	5.8	NUM
admet-909	70	9	(	(	PUNCT
admet-909	70	10	0.4	0.4	NUM
admet-909	70	11	)	)	PUNCT
admet-909	70	12	;	;	PUNCT
admet-909	70	13	k	k	X
admet-909	70	14	(	(	PUNCT
admet-909	70	15	per	per	ADP
admet-909	70	16	day	day	NOUN
admet-909	70	17	)	)	PUNCT
admet-909	70	18	–	–	PUNCT
admet-909	70	19	1	1	NUM
admet-909	70	20	(	(	PUNCT
admet-909	70	21	0.05	0.05	NUM
admet-909	70	22	)	)	PUNCT
admet-909	70	23	;	;	PUNCT
admet-909	70	24	cl	cl	INTJ
admet-909	70	25	(	(	PUNCT
admet-909	70	26	l	l	NOUN
admet-909	70	27	/	/	SYM
admet-909	70	28	day	day	NOUN
admet-909	70	29	)	)	PUNCT
admet-909	70	30	–	–	PUNCT
admet-909	70	31	2.1	2.1	NUM
admet-909	70	32	(	(	PUNCT
admet-909	70	33	0.2	0.2	NUM
admet-909	70	34	)	)	PUNCT
admet-909	70	35	;	;	PUNCT
admet-909	70	36	and	and	CCONJ
admet-909	70	37	vd	vd	NOUN
admet-909	70	38	(	(	PUNCT
admet-909	70	39	l	l	NOUN
admet-909	70	40	)	)	PUNCT
admet-909	70	41	–	–	PUNCT
admet-909	70	42	7.7	7.7	NUM
admet-909	70	43	(	(	PUNCT
admet-909	70	44	0.2	0.2	NUM
admet-909	70	45	)	)	PUNCT
admet-909	70	46	]	]	PUNCT
admet-909	70	47	.	.	PUNCT
admet-909	71	1	significant	significant	ADJ
admet-909	71	2	correlations	correlation	NOUN
admet-909	71	3	were	be	AUX
admet-909	71	4	observed	observe	VERB
admet-909	71	5	between	between	ADP
admet-909	71	6	cmax	cmax	NOUN
admet-909	71	7	and	and	CCONJ
admet-909	71	8	cl	cl	INTJ
admet-909	71	9	(	(	PUNCT
admet-909	71	10	r	r	NOUN
admet-909	71	11	=	=	SYM
admet-909	71	12	0.4	0.4	NUM
admet-909	71	13	;	;	PUNCT
admet-909	71	14	p=0.0001	p=0.0001	PROPN
admet-909	71	15	)	)	PUNCT
admet-909	71	16	,	,	PUNCT
admet-909	71	17	vd	vd	NOUN
admet-909	71	18	(	(	PUNCT
admet-909	71	19	r	r	NOUN
admet-909	71	20	=	=	SYM
admet-909	71	21	0.28	0.28	NUM
admet-909	71	22	;	;	PUNCT
admet-909	72	1	p	p	X
admet-909	72	2	=	=	NOUN
admet-909	72	3	0.004	0.004	NUM
admet-909	72	4	)	)	PUNCT
admet-909	72	5	and	and	CCONJ
admet-909	72	6	k	k	X
admet-909	72	7	(	(	PUNCT
admet-909	72	8	r	r	NOUN
admet-909	72	9	=	=	NOUN
admet-909	72	10	0.8	0.8	NUM
admet-909	72	11	;	;	PUNCT
admet-909	72	12	p	p	PROPN
admet-909	72	13	=	=	NOUN
admet-909	72	14	0.0001	0.0001	NUM
admet-909	72	15	)	)	PUNCT
admet-909	72	16	(	(	PUNCT
admet-909	72	17	figure	figure	NOUN
admet-909	72	18	3	3	NUM
admet-909	72	19	)	)	PUNCT
admet-909	72	20	.	.	PUNCT
admet-909	73	1	association	association	NOUN
admet-909	73	2	between	between	ADP
admet-909	73	3	liver	liver	NOUN
admet-909	73	4	weights	weight	NOUN
admet-909	73	5	and	and	CCONJ
admet-909	73	6	predicted	predict	VERB
admet-909	73	7	pharmacokinetic	pharmacokinetic	ADJ
admet-909	73	8	parameters	parameter	NOUN
admet-909	73	9	scatterplot	scatterplot	NOUN
admet-909	73	10	revealed	reveal	VERB
admet-909	73	11	significant	significant	ADJ
admet-909	73	12	correlations	correlation	NOUN
admet-909	73	13	between	between	ADP
admet-909	73	14	warfarin	warfarin	NOUN
admet-909	73	15	cl	cl	NOUN
admet-909	73	16	(	(	PUNCT
admet-909	73	17	r=0.2	r=0.2	NOUN
admet-909	73	18	;	;	PUNCT
admet-909	73	19	p=0.04	p=0.04	NOUN
admet-909	73	20	)	)	PUNCT
admet-909	73	21	and	and	CCONJ
admet-909	73	22	vd	vd	NOUN
admet-909	73	23	(	(	PUNCT
admet-909	73	24	r=	r=	ADJ
admet-909	73	25	-0.2	-0.2	NOUN
admet-909	73	26	;	;	PUNCT
admet-909	73	27	p=0.03	p=0.03	ADV
admet-909	73	28	)	)	PUNCT
admet-909	73	29	with	with	ADP
admet-909	73	30	weight	weight	NOUN
admet-909	73	31	of	of	ADP
admet-909	73	32	the	the	DET
admet-909	73	33	liver	liver	NOUN
admet-909	73	34	(	(	PUNCT
admet-909	73	35	figure	figure	NOUN
admet-909	73	36	3	3	NUM
admet-909	73	37	)	)	PUNCT
admet-909	73	38	.	.	PUNCT
admet-909	74	1	variables	variable	NOUN
admet-909	74	2	values	value	NOUN
admet-909	74	3	age	age	NOUN
admet-909	74	4	(	(	PUNCT
admet-909	74	5	years	year	NOUN
admet-909	74	6	)	)	PUNCT
admet-909	74	7	$	$	SYM
admet-909	74	8	66.6	66.6	NUM
admet-909	74	9	(	(	PUNCT
admet-909	74	10	13.4	13.4	NUM
admet-909	74	11	)	)	PUNCT
admet-909	74	12	male	male	NOUN
admet-909	74	13	:	:	PUNCT
admet-909	74	14	female	female	ADJ
admet-909	74	15	1	1	NUM
admet-909	74	16	:	:	SYM
admet-909	74	17	1	1	NUM
admet-909	74	18	body	body	NOUN
admet-909	74	19	weight	weight	NOUN
admet-909	74	20	(	(	PUNCT
admet-909	74	21	kg	kg	NOUN
admet-909	74	22	)	)	PUNCT
admet-909	74	23	$	$	SYM
admet-909	74	24	75.2	75.2	NUM
admet-909	74	25	(	(	PUNCT
admet-909	74	26	18.1	18.1	NUM
admet-909	74	27	)	)	PUNCT
admet-909	74	28	predicted	predict	VERB
admet-909	74	29	liver	liver	NOUN
admet-909	74	30	weight	weight	NOUN
admet-909	74	31	(	(	PUNCT
admet-909	74	32	g	g	NOUN
admet-909	74	33	)	)	PUNCT
admet-909	74	34	$	$	SYM
admet-909	74	35	1148	1148	NUM
admet-909	74	36	(	(	PUNCT
admet-909	74	37	265	265	NUM
admet-909	74	38	)	)	PUNCT
admet-909	74	39	cha2ds2	cha2ds2	PROPN
admet-909	74	40	-	-	PUNCT
admet-909	74	41	vasc	vasc	VERB
admet-909	74	42	score	score	NOUN
admet-909	74	43	$	$	SYM
admet-909	74	44	3.7	3.7	NUM
admet-909	74	45	(	(	PUNCT
admet-909	74	46	1.5	1.5	NUM
admet-909	74	47	)	)	PUNCT
admet-909	74	48	hasbled	hasble	VERB
admet-909	74	49	score	score	NOUN
admet-909	74	50	$	$	SYM
admet-909	74	51	2.3	2.3	NUM
admet-909	74	52	(	(	PUNCT
admet-909	74	53	1.1	1.1	NUM
admet-909	74	54	)	)	PUNCT
admet-909	74	55	same	same	ADJ
admet-909	74	56	-	-	PUNCT
admet-909	74	57	tt2r2	tt2r2	NOUN
admet-909	74	58	score	score	NOUN
admet-909	74	59	$	$	SYM
admet-909	74	60	1.4	1.4	NUM
admet-909	74	61	(	(	PUNCT
admet-909	74	62	0.6	0.6	NUM
admet-909	74	63	)	)	PUNCT
admet-909	74	64	duration	duration	NOUN
admet-909	74	65	of	of	ADP
admet-909	74	66	warfarin	warfarin	NOUN
admet-909	74	67	(	(	PUNCT
admet-909	74	68	days	day	NOUN
admet-909	74	69	)	)	PUNCT
admet-909	74	70	$	$	SYM
admet-909	74	71	1027	1027	NUM
admet-909	74	72	(	(	PUNCT
admet-909	74	73	572.2	572.2	NUM
admet-909	74	74	)	)	PUNCT
admet-909	74	75	warfarin	warfarin	NOUN
admet-909	74	76	sensitive	sensitive	ADJ
admet-909	74	77	index	index	NOUN
admet-909	74	78	$	$	SYM
admet-909	74	79	0.7	0.7	NUM
admet-909	74	80	(	(	PUNCT
admet-909	74	81	0.4	0.4	NUM
admet-909	74	82	)	)	PUNCT
admet-909	74	83	log	log	VERB
admet-909	74	84	inr	inr	NOUN
admet-909	74	85	variability	variability	NOUN
admet-909	74	86	$	$	SYM
admet-909	74	87	-0.84	-0.84	NUM
admet-909	74	88	(	(	PUNCT
admet-909	74	89	0.2	0.2	NUM
admet-909	74	90	)	)	PUNCT
admet-909	74	91	warfarin	warfarin	NOUN
admet-909	74	92	composite	composite	ADJ
admet-909	74	93	measure	measure	NOUN
admet-909	74	94	score	score	VERB
admet-909	74	95	$	$	SYM
admet-909	74	96	-1.3	-1.3	PROPN
admet-909	74	97	(	(	PUNCT
admet-909	74	98	1.2	1.2	NUM
admet-909	74	99	)	)	PUNCT
admet-909	74	100	number	number	NOUN
admet-909	74	101	of	of	ADP
admet-909	74	102	patients	patient	NOUN
admet-909	74	103	with	with	ADP
admet-909	74	104	drugs	drug	NOUN
admet-909	74	105	with	with	ADP
admet-909	74	106	potential	potential	ADJ
admet-909	74	107	interaction	interaction	NOUN
admet-909	74	108	[	[	X
admet-909	74	109	n	n	X
admet-909	74	110	(	(	PUNCT
admet-909	74	111	%	%	NOUN
admet-909	74	112	)	)	PUNCT
admet-909	74	113	]	]	PUNCT
admet-909	75	1	136	136	NUM
admet-909	75	2	(	(	PUNCT
admet-909	75	3	61.8	61.8	NUM
admet-909	75	4	)	)	PUNCT
admet-909	75	5	$	$	SYM
admet-909	75	6	represented	represent	VERB
admet-909	75	7	in	in	ADP
admet-909	75	8	mean	mean	PROPN
admet-909	75	9	(	(	PUNCT
admet-909	75	10	sd	sd	NOUN
admet-909	75	11	)	)	PUNCT
admet-909	75	12	https://dx.doi.org/10.5599/admet.909	https://dx.doi.org/10.5599/admet.909	PROPN
admet-909	76	1	k.	k.	PROPN
admet-909	77	1	sridharan	sridharan	VERB
admet-909	77	2	et	et	PROPN
admet-909	77	3	al	al	PROPN
admet-909	77	4	.	.	PROPN
admet-909	77	5	admet	admet	PROPN
admet-909	77	6	&	&	CCONJ
admet-909	77	7	dmpk	dmpk	PROPN
admet-909	77	8	9(2	9(2	NUM
admet-909	77	9	)	)	PUNCT
admet-909	77	10	(	(	PUNCT
admet-909	77	11	2021	2021	NUM
admet-909	77	12	)	)	PUNCT
admet-909	77	13	143	143	NUM
admet-909	77	14	-	-	SYM
admet-909	77	15	149	149	NUM
admet-909	77	16	146	146	NUM
admet-909	77	17	figure	figure	NOUN
admet-909	77	18	1	1	NUM
admet-909	77	19	.	.	PUNCT
admet-909	77	20	distribution	distribution	NOUN
admet-909	77	21	of	of	ADP
admet-909	77	22	pharmacokinetic	pharmacokinetic	ADJ
admet-909	77	23	parameters	parameter	NOUN
admet-909	77	24	in	in	ADP
admet-909	77	25	the	the	DET
admet-909	77	26	study	study	NOUN
admet-909	77	27	population	population	NOUN
admet-909	77	28	.	.	PUNCT
admet-909	78	1	(	(	PUNCT
admet-909	78	2	a	a	X
admet-909	78	3	)	)	PUNCT
admet-909	78	4	distribution	distribution	NOUN
admet-909	78	5	of	of	ADP
admet-909	78	6	cmax	cmax	NOUN
admet-909	78	7	(	(	PUNCT
admet-909	78	8	mg	mg	PROPN
admet-909	78	9	/	/	SYM
admet-909	78	10	l	l	NOUN
admet-909	78	11	)	)	PUNCT
admet-909	78	12	;	;	PUNCT
admet-909	78	13	(	(	PUNCT
admet-909	78	14	b	b	X
admet-909	78	15	)	)	PUNCT
admet-909	78	16	elimination	elimination	NOUN
admet-909	78	17	rate	rate	NOUN
admet-909	78	18	(	(	PUNCT
admet-909	78	19	per	per	ADP
admet-909	78	20	day	day	NOUN
admet-909	78	21	)	)	PUNCT
admet-909	78	22	;	;	PUNCT
admet-909	78	23	(	(	PUNCT
admet-909	78	24	c	c	X
admet-909	78	25	)	)	PUNCT
admet-909	78	26	clearance	clearance	NOUN
admet-909	78	27	(	(	PUNCT
admet-909	78	28	l	l	NOUN
admet-909	78	29	/	/	SYM
admet-909	78	30	day	day	NOUN
admet-909	78	31	)	)	PUNCT
admet-909	78	32	;	;	PUNCT
admet-909	78	33	(	(	PUNCT
admet-909	78	34	d	d	X
admet-909	78	35	)	)	PUNCT
admet-909	78	36	volume	volume	NOUN
admet-909	78	37	of	of	ADP
admet-909	78	38	distribution	distribution	NOUN
admet-909	78	39	(	(	PUNCT
admet-909	78	40	l	l	NOUN
admet-909	78	41	)	)	PUNCT
admet-909	78	42	in	in	ADP
admet-909	78	43	the	the	DET
admet-909	78	44	study	study	NOUN
admet-909	78	45	population	population	NOUN
admet-909	78	46	table	table	NOUN
admet-909	78	47	2	2	NUM
admet-909	78	48	.	.	PUNCT
admet-909	78	49	comparison	comparison	NOUN
admet-909	78	50	of	of	ADP
admet-909	78	51	characteristics	characteristic	NOUN
admet-909	78	52	between	between	ADP
admet-909	78	53	those	those	PRON
admet-909	78	54	within	within	ADP
admet-909	78	55	and	and	CCONJ
admet-909	78	56	outside	outside	ADP
admet-909	78	57	95	95	NUM
admet-909	78	58	%	%	NOUN
admet-909	78	59	of	of	ADP
admet-909	78	60	normal	normal	ADJ
admet-909	78	61	distribution	distribution	NOUN
admet-909	78	62	curves	curve	NOUN
admet-909	78	63	in	in	ADP
admet-909	78	64	the	the	DET
admet-909	78	65	study	study	NOUN
admet-909	78	66	population	population	NOUN
admet-909	78	67	variables	variable	NOUN
admet-909	78	68	cmax	cmax	VERB
admet-909	78	69	(	(	PUNCT
admet-909	78	70	mg	mg	PROPN
admet-909	78	71	/	/	SYM
admet-909	78	72	l	l	NOUN
admet-909	78	73	)	)	PUNCT
admet-909	78	74	elimination	elimination	NOUN
admet-909	78	75	rate	rate	NOUN
admet-909	78	76	(	(	PUNCT
admet-909	78	77	per	per	ADP
admet-909	78	78	day	day	NOUN
admet-909	78	79	)	)	PUNCT
admet-909	78	80	within	within	ADP
admet-909	78	81	95	95	NUM
admet-909	78	82	%	%	NOUN
admet-909	78	83	of	of	ADP
admet-909	78	84	nd	nd	PROPN
admet-909	78	85	(	(	PUNCT
admet-909	78	86	n=	n=	ADJ
admet-909	78	87	201	201	NUM
admet-909	78	88	)	)	PUNCT
admet-909	78	89	outside	outside	ADP
admet-909	78	90	95	95	NUM
admet-909	78	91	%	%	NOUN
admet-909	78	92	of	of	ADP
admet-909	78	93	nd	nd	PROPN
admet-909	78	94	(	(	PUNCT
admet-909	78	95	n=	n=	ADJ
admet-909	78	96	19	19	NUM
admet-909	78	97	)	)	PUNCT
admet-909	78	98	p	p	NOUN
admet-909	78	99	-	-	PUNCT
admet-909	78	100	values	value	NOUN
admet-909	78	101	within	within	ADP
admet-909	78	102	95	95	NUM
admet-909	78	103	%	%	NOUN
admet-909	78	104	of	of	ADP
admet-909	78	105	nd	nd	PROPN
admet-909	78	106	(	(	PUNCT
admet-909	78	107	n=206	n=206	NOUN
admet-909	78	108	)	)	PUNCT
admet-909	78	109	outside	outside	ADP
admet-909	78	110	95	95	NUM
admet-909	78	111	%	%	NOUN
admet-909	78	112	of	of	ADP
admet-909	78	113	nd	nd	PROPN
admet-909	78	114	(	(	PUNCT
admet-909	78	115	n=14	n=14	NOUN
admet-909	78	116	)	)	PUNCT
admet-909	78	117	p	p	NOUN
admet-909	78	118	-	-	PUNCT
admet-909	78	119	values	value	NOUN
admet-909	78	120	age	age	NOUN
admet-909	78	121	(	(	PUNCT
admet-909	78	122	years	year	NOUN
admet-909	78	123	)	)	PUNCT
admet-909	78	124	$	$	SYM
admet-909	78	125	67.1	67.1	NUM
admet-909	78	126	(	(	PUNCT
admet-909	78	127	13.3	13.3	NUM
admet-909	78	128	)	)	PUNCT
admet-909	78	129	61.7	61.7	NUM
admet-909	78	130	(	(	PUNCT
admet-909	78	131	13.7	13.7	NUM
admet-909	78	132	)	)	PUNCT
admet-909	78	133	0.7	0.7	NUM
admet-909	78	134	68.6	68.6	NUM
admet-909	78	135	(	(	PUNCT
admet-909	78	136	12.7	12.7	NUM
admet-909	78	137	)	)	PUNCT
admet-909	78	138	64.2	64.2	NUM
admet-909	78	139	(	(	PUNCT
admet-909	78	140	14.5	14.5	NUM
admet-909	78	141	)	)	PUNCT
admet-909	78	142	0.6	0.6	NUM
admet-909	78	143	body	body	NOUN
admet-909	78	144	weight	weight	NOUN
admet-909	78	145	(	(	PUNCT
admet-909	78	146	kg	kg	NOUN
admet-909	78	147	)	)	PUNCT
admet-909	78	148	$	$	SYM
admet-909	78	149	75	75	NUM
admet-909	78	150	(	(	PUNCT
admet-909	78	151	18.4	18.4	NUM
admet-909	78	152	)	)	PUNCT
admet-909	78	153	77.6	77.6	NUM
admet-909	78	154	(	(	PUNCT
admet-909	78	155	14.1	14.1	NUM
admet-909	78	156	)	)	PUNCT
admet-909	78	157	0.4	0.4	NUM
admet-909	78	158	72.8	72.8	NUM
admet-909	78	159	(	(	PUNCT
admet-909	78	160	19	19	NUM
admet-909	78	161	)	)	PUNCT
admet-909	78	162	81.6	81.6	NUM
admet-909	78	163	(	(	PUNCT
admet-909	78	164	12	12	NUM
admet-909	78	165	)	)	PUNCT
admet-909	78	166	0.2	0.2	NUM
admet-909	78	167	ttr	ttr	NOUN
admet-909	78	168	(	(	PUNCT
admet-909	78	169	%	%	INTJ
admet-909	78	170	)	)	PUNCT
admet-909	78	171	$	$	SYM
admet-909	78	172	65.6	65.6	NUM
admet-909	78	173	(	(	PUNCT
admet-909	78	174	17.2	17.2	NUM
admet-909	78	175	)	)	PUNCT
admet-909	78	176	64.7	64.7	NUM
admet-909	78	177	(	(	PUNCT
admet-909	78	178	16.4	16.4	NUM
admet-909	78	179	)	)	PUNCT
admet-909	78	180	0.6	0.6	NUM
admet-909	78	181	65.7	65.7	NUM
admet-909	78	182	(	(	PUNCT
admet-909	78	183	16.1	16.1	NUM
admet-909	78	184	)	)	PUNCT
admet-909	78	185	65	65	NUM
admet-909	78	186	(	(	PUNCT
admet-909	78	187	21	21	NUM
admet-909	78	188	)	)	PUNCT
admet-909	78	189	1	1	NUM
admet-909	78	190	wsi	wsi	PROPN
admet-909	78	191	$	$	SYM
admet-909	78	192	0.7	0.7	NUM
admet-909	78	193	(	(	PUNCT
admet-909	78	194	0.4	0.4	NUM
admet-909	78	195	)	)	PUNCT
admet-909	78	196	0.3	0.3	NUM
admet-909	78	197	(	(	PUNCT
admet-909	78	198	0.1	0.1	NUM
admet-909	78	199	)	)	PUNCT
admet-909	78	200	0.0001	0.0001	NUM
admet-909	78	201	*	*	NUM
admet-909	78	202	0.8	0.8	NUM
admet-909	78	203	(	(	PUNCT
admet-909	78	204	0.4	0.4	NUM
admet-909	78	205	)	)	PUNCT
admet-909	78	206	0.3	0.3	NUM
admet-909	78	207	(	(	PUNCT
admet-909	78	208	0.1	0.1	NUM
admet-909	78	209	)	)	PUNCT
admet-909	78	210	0.0001	0.0001	NUM
admet-909	78	211	*	*	PUNCT
admet-909	78	212	log	log	NOUN
admet-909	78	213	inr	inr	PROPN
admet-909	78	214	variability	variability	NOUN
admet-909	78	215	$	$	SYM
admet-909	78	216	-0.8	-0.8	NOUN
admet-909	78	217	(	(	PUNCT
admet-909	78	218	0.2	0.2	NUM
admet-909	78	219	)	)	PUNCT
admet-909	78	220	-0.9	-0.9	NOUN
admet-909	78	221	(	(	PUNCT
admet-909	78	222	0.2	0.2	NUM
admet-909	78	223	)	)	PUNCT
admet-909	78	224	0.06	0.06	NUM
admet-909	78	225	-0.8	-0.8	NUM
admet-909	78	226	(	(	PUNCT
admet-909	78	227	0.2	0.2	NUM
admet-909	78	228	)	)	PUNCT
admet-909	78	229	-0.9	-0.9	NOUN
admet-909	78	230	(	(	PUNCT
admet-909	78	231	0.2	0.2	NUM
admet-909	78	232	)	)	PUNCT
admet-909	78	233	0.06	0.06	NUM
admet-909	78	234	wcm	wcm	NOUN
admet-909	78	235	$	$	SYM
admet-909	78	236	-1.2	-1.2	NOUN
admet-909	78	237	(	(	PUNCT
admet-909	78	238	1.2	1.2	NUM
admet-909	78	239	)	)	PUNCT
admet-909	78	240	-1.8	-1.8	NOUN
admet-909	78	241	(	(	PUNCT
admet-909	78	242	0.9	0.9	NUM
admet-909	78	243	)	)	PUNCT
admet-909	78	244	0.004	0.004	NUM
admet-909	78	245	*	*	SYM
admet-909	78	246	-1.1	-1.1	X
admet-909	78	247	(	(	PUNCT
admet-909	78	248	1.2	1.2	NUM
admet-909	78	249	)	)	PUNCT
admet-909	78	250	-1.7	-1.7	PROPN
admet-909	78	251	(	(	PUNCT
admet-909	78	252	1.1	1.1	NUM
admet-909	78	253	)	)	PUNCT
admet-909	78	254	0.08	0.08	NUM
admet-909	78	255	potentially	potentially	ADV
admet-909	78	256	interacting	interact	VERB
admet-909	78	257	drugs	drug	NOUN
admet-909	78	258	[	[	X
admet-909	78	259	n	n	X
admet-909	78	260	(	(	PUNCT
admet-909	78	261	%	%	NOUN
admet-909	78	262	)	)	PUNCT
admet-909	78	263	]	]	PUNCT
admet-909	78	264	123	123	NUM
admet-909	78	265	(	(	PUNCT
admet-909	78	266	61.2	61.2	NUM
admet-909	78	267	)	)	PUNCT
admet-909	78	268	12	12	NUM
admet-909	78	269	(	(	PUNCT
admet-909	78	270	63.2	63.2	NUM
admet-909	78	271	)	)	PUNCT
admet-909	78	272	0.9	0.9	NUM
admet-909	78	273	135	135	NUM
admet-909	78	274	(	(	PUNCT
admet-909	78	275	65.5	65.5	NUM
admet-909	78	276	)	)	SYM
admet-909	78	277	8	8	NUM
admet-909	78	278	(	(	PUNCT
admet-909	78	279	57.1	57.1	NUM
admet-909	78	280	)	)	PUNCT
admet-909	78	281	0.5	0.5	NUM
admet-909	78	282	y	y	PROPN
admet-909	78	283	-	-	PUNCT
admet-909	78	284	young	young	ADJ
admet-909	78	285	;	;	PUNCT
admet-909	78	286	m	m	NOUN
admet-909	78	287	-	-	ADJ
admet-909	78	288	middle	middle	ADJ
admet-909	78	289	-	-	PUNCT
admet-909	78	290	aged	aged	ADJ
admet-909	78	291	&	&	CCONJ
admet-909	78	292	older	old	ADJ
admet-909	78	293	adults	adult	NOUN
admet-909	78	294	;	;	PUNCT
admet-909	78	295	e	e	X
admet-909	78	296	–	–	PUNCT
admet-909	78	297	elderly	elderly	ADJ
admet-909	78	298	;	;	PUNCT
admet-909	78	299	ve	ve	NOUN
admet-909	78	300	–	–	PUNCT
admet-909	78	301	very	very	ADV
admet-909	78	302	elderly	elderly	ADJ
admet-909	78	303	;	;	PUNCT
admet-909	78	304	ttr	ttr	PROPN
admet-909	78	305	–	–	PUNCT
admet-909	78	306	time	time	NOUN
admet-909	78	307	spent	spend	VERB
admet-909	78	308	in	in	ADP
admet-909	78	309	therapeutic	therapeutic	ADJ
admet-909	78	310	range	range	NOUN
admet-909	78	311	;	;	PUNCT
admet-909	78	312	wsi	wsi	PROPN
admet-909	78	313	–	–	PUNCT
admet-909	78	314	warfarin	warfarin	NOUN
admet-909	78	315	sensitive	sensitive	ADJ
admet-909	78	316	index	index	NOUN
admet-909	78	317	;	;	PUNCT
admet-909	78	318	wcm	wcm	NOUN
admet-909	78	319	–	–	PUNCT
admet-909	78	320	warfarin	warfarin	NOUN
admet-909	78	321	composite	composite	ADJ
admet-909	78	322	measure	measure	NOUN
admet-909	78	323	;	;	PUNCT
admet-909	78	324	nd	nd	X
admet-909	78	325	–	–	PUNCT
admet-909	78	326	normal	normal	ADJ
admet-909	78	327	distribution	distribution	NOUN
admet-909	78	328	;	;	PUNCT
admet-909	78	329	$	$	SYM
admet-909	78	330	represented	represent	VERB
admet-909	78	331	in	in	ADP
admet-909	78	332	mean	mean	PROPN
admet-909	78	333	(	(	PUNCT
admet-909	78	334	sd	sd	NOUN
admet-909	78	335	)	)	PUNCT
admet-909	78	336	;	;	PUNCT
admet-909	78	337	*	*	PUNCT
admet-909	78	338	statistically	statistically	ADV
admet-909	78	339	significant	significant	ADJ
admet-909	78	340	.	.	PUNCT
admet-909	79	1	(	(	PUNCT
admet-909	79	2	a	a	X
admet-909	79	3	)	)	PUNCT
admet-909	79	4	(	(	PUNCT
admet-909	79	5	b	b	X
admet-909	79	6	)	)	PUNCT
admet-909	79	7	(	(	PUNCT
admet-909	79	8	c	c	X
admet-909	79	9	)	)	PUNCT
admet-909	79	10	(	(	PUNCT
admet-909	79	11	d	d	X
admet-909	79	12	)	)	PUNCT
admet-909	79	13	admet	admet	PROPN
admet-909	79	14	&	&	CCONJ
admet-909	79	15	dmpk	dmpk	PROPN
admet-909	79	16	9(2	9(2	NUM
admet-909	79	17	)	)	PUNCT
admet-909	79	18	(	(	PUNCT
admet-909	79	19	2021	2021	NUM
admet-909	79	20	)	)	PUNCT
admet-909	79	21	143	143	NUM
admet-909	79	22	-	-	SYM
admet-909	79	23	149	149	NUM
admet-909	79	24	warfarin	warfarin	NOUN
admet-909	79	25	pharmacokinetics	pharmacokinetic	NOUN
admet-909	79	26	doi	doi	NOUN
admet-909	79	27	:	:	PUNCT
admet-909	79	28	https://dx.doi.org/10.5599/admet.909	https://dx.doi.org/10.5599/admet.909	PROPN
admet-909	79	29	147	147	NUM
admet-909	79	30	figure	figure	NOUN
admet-909	79	31	2	2	NUM
admet-909	79	32	.	.	PUNCT
admet-909	79	33	predicted	predict	VERB
admet-909	79	34	pharmacokinetic	pharmacokinetic	ADJ
admet-909	79	35	parameters	parameter	NOUN
admet-909	79	36	of	of	ADP
admet-909	79	37	warfarin	warfarin	NOUN
admet-909	79	38	in	in	ADP
admet-909	79	39	different	different	ADJ
admet-909	79	40	age	age	NOUN
admet-909	79	41	groups	group	NOUN
admet-909	79	42	.	.	PUNCT
admet-909	80	1	(	(	PUNCT
admet-909	80	2	a	a	X
admet-909	80	3	)	)	PUNCT
admet-909	80	4	predicted	predict	VERB
admet-909	80	5	cmax	cmax	NOUN
admet-909	80	6	(	(	PUNCT
admet-909	80	7	mg	mg	PROPN
admet-909	80	8	/	/	SYM
admet-909	80	9	l	l	NOUN
admet-909	80	10	)	)	PUNCT
admet-909	80	11	;	;	PUNCT
admet-909	80	12	(	(	PUNCT
admet-909	80	13	b	b	X
admet-909	80	14	)	)	PUNCT
admet-909	80	15	predicted	predict	VERB
admet-909	80	16	elimination	elimination	NOUN
admet-909	80	17	(	(	PUNCT
admet-909	80	18	l	l	NOUN
admet-909	80	19	/	/	SYM
admet-909	80	20	day	day	NOUN
admet-909	80	21	)	)	PUNCT
admet-909	80	22	;	;	PUNCT
admet-909	80	23	(	(	PUNCT
admet-909	80	24	c	c	X
admet-909	80	25	)	)	PUNCT
admet-909	80	26	predicted	predict	VERB
admet-909	80	27	clearance	clearance	NOUN
admet-909	80	28	(	(	PUNCT
admet-909	80	29	l	l	NOUN
admet-909	80	30	/	/	SYM
admet-909	80	31	day	day	NOUN
admet-909	80	32	)	)	PUNCT
admet-909	80	33	;	;	PUNCT
admet-909	80	34	(	(	PUNCT
admet-909	80	35	d	d	X
admet-909	80	36	)	)	PUNCT
admet-909	80	37	predicted	predict	VERB
admet-909	80	38	vd	vd	NOUN
admet-909	80	39	(	(	PUNCT
admet-909	80	40	l	l	NOUN
admet-909	80	41	)	)	PUNCT
admet-909	80	42	in	in	ADP
admet-909	80	43	different	different	ADJ
admet-909	80	44	age	age	NOUN
admet-909	80	45	groups	group	NOUN
admet-909	80	46	.	.	PUNCT
admet-909	81	1	figure	figure	VERB
admet-909	81	2	3	3	NUM
admet-909	81	3	.	.	PUNCT
admet-909	81	4	scatter	scatter	NOUN
admet-909	81	5	plot	plot	NOUN
admet-909	81	6	matrix	matrix	NOUN
admet-909	81	7	between	between	ADP
admet-909	81	8	the	the	DET
admet-909	81	9	pharmacokinetic	pharmacokinetic	ADJ
admet-909	81	10	parameters	parameter	NOUN
admet-909	81	11	and	and	CCONJ
admet-909	81	12	the	the	DET
admet-909	81	13	liver	liver	NOUN
admet-909	81	14	weight	weight	NOUN
admet-909	81	15	.	.	PUNCT
admet-909	82	1	warfarin	warfarin	NOUN
admet-909	82	2	clearance	clearance	NOUN
admet-909	82	3	and	and	CCONJ
admet-909	82	4	volume	volume	NOUN
admet-909	82	5	of	of	ADP
admet-909	82	6	distribution	distribution	NOUN
admet-909	82	7	were	be	AUX
admet-909	82	8	significantly	significantly	ADV
admet-909	82	9	correlated	correlate	VERB
admet-909	82	10	with	with	ADP
admet-909	82	11	the	the	DET
admet-909	82	12	weight	weight	NOUN
admet-909	82	13	of	of	ADP
admet-909	82	14	the	the	DET
admet-909	82	15	liver	liver	NOUN
admet-909	82	16	.	.	PUNCT
admet-909	83	1	clclearance	clclearance	NOUN
admet-909	83	2	;	;	PUNCT
admet-909	83	3	k	k	X
admet-909	83	4	–	–	PUNCT
admet-909	83	5	elimination	elimination	NOUN
admet-909	83	6	rate	rate	NOUN
admet-909	83	7	;	;	PUNCT
admet-909	83	8	vd	vd	X
admet-909	83	9	–	–	PUNCT
admet-909	83	10	volume	volume	NOUN
admet-909	83	11	of	of	ADP
admet-909	83	12	distribution	distribution	NOUN
admet-909	83	13	(	(	PUNCT
admet-909	83	14	a	a	X
admet-909	83	15	)	)	PUNCT
admet-909	83	16	(	(	PUNCT
admet-909	83	17	b	b	X
admet-909	83	18	)	)	PUNCT
admet-909	83	19	(	(	PUNCT
admet-909	83	20	c	c	X
admet-909	83	21	)	)	PUNCT
admet-909	83	22	(	(	PUNCT
admet-909	83	23	d	d	X
admet-909	83	24	)	)	PUNCT
admet-909	83	25	https://dx.doi.org/10.5599/admet.909	https://dx.doi.org/10.5599/admet.909	PROPN
admet-909	84	1	k.	k.	PROPN
admet-909	85	1	sridharan	sridharan	VERB
admet-909	85	2	et	et	PROPN
admet-909	85	3	al	al	PROPN
admet-909	85	4	.	.	PROPN
admet-909	85	5	admet	admet	PROPN
admet-909	85	6	&	&	CCONJ
admet-909	85	7	dmpk	dmpk	PROPN
admet-909	85	8	9(2	9(2	NUM
admet-909	85	9	)	)	PUNCT
admet-909	85	10	(	(	PUNCT
admet-909	85	11	2021	2021	NUM
admet-909	85	12	)	)	PUNCT
admet-909	85	13	143	143	NUM
admet-909	85	14	-	-	SYM
admet-909	85	15	149	149	NUM
admet-909	85	16	148	148	NUM
admet-909	85	17	discussion	discussion	NOUN
admet-909	85	18	we	we	PRON
admet-909	85	19	evaluated	evaluate	VERB
admet-909	85	20	the	the	DET
admet-909	85	21	pharmacokinetic	pharmacokinetic	ADJ
admet-909	85	22	parameters	parameter	NOUN
admet-909	85	23	of	of	ADP
admet-909	85	24	warfarin	warfarin	NOUN
admet-909	85	25	using	use	VERB
admet-909	85	26	validated	validate	VERB
admet-909	85	27	pk	pk	NOUN
admet-909	85	28	-	-	PUNCT
admet-909	85	29	pd	pd	NOUN
admet-909	85	30	model	model	NOUN
admet-909	85	31	in	in	ADP
admet-909	85	32	our	our	PRON
admet-909	85	33	population	population	NOUN
admet-909	85	34	.	.	PUNCT
admet-909	86	1	two	two	NUM
admet-909	86	2	-	-	PUNCT
admet-909	86	3	hundred	hundred	NUM
admet-909	86	4	and	and	CCONJ
admet-909	86	5	twenty	twenty	NUM
admet-909	86	6	patients	patient	NOUN
admet-909	86	7	were	be	AUX
admet-909	86	8	recruited	recruit	VERB
admet-909	86	9	.	.	PUNCT
admet-909	87	1	the	the	DET
admet-909	87	2	following	follow	VERB
admet-909	87	3	were	be	AUX
admet-909	87	4	the	the	DET
admet-909	87	5	predicted	predict	VERB
admet-909	87	6	pharmacokinetic	pharmacokinetic	ADJ
admet-909	87	7	parameters	parameter	NOUN
admet-909	87	8	:	:	PUNCT
admet-909	87	9	cmax	cmax	NOUN
admet-909	87	10	(	(	PUNCT
admet-909	87	11	mg	mg	PROPN
admet-909	87	12	/	/	SYM
admet-909	87	13	l	l	NOUN
admet-909	87	14	)	)	PUNCT
admet-909	87	15	was	be	AUX
admet-909	87	16	5.8	5.8	NUM
admet-909	87	17	(	(	PUNCT
admet-909	87	18	0.4	0.4	NUM
admet-909	87	19	)	)	PUNCT
admet-909	87	20	;	;	PUNCT
admet-909	87	21	elimination	elimination	NOUN
admet-909	87	22	rate	rate	NOUN
admet-909	87	23	(	(	PUNCT
admet-909	87	24	l	l	NOUN
admet-909	87	25	/	/	SYM
admet-909	87	26	day	day	NOUN
admet-909	87	27	)	)	PUNCT
admet-909	87	28	was	be	AUX
admet-909	87	29	1	1	NUM
admet-909	87	30	(	(	PUNCT
admet-909	87	31	0.1	0.1	NUM
admet-909	87	32	)	)	PUNCT
admet-909	87	33	;	;	PUNCT
admet-909	87	34	cl	cl	INTJ
admet-909	87	35	(	(	PUNCT
admet-909	87	36	l	l	NOUN
admet-909	87	37	/	/	SYM
admet-909	87	38	day	day	NOUN
admet-909	87	39	)	)	PUNCT
admet-909	87	40	was	be	AUX
admet-909	87	41	2.1	2.1	NUM
admet-909	87	42	(	(	PUNCT
admet-909	87	43	0.2	0.2	NUM
admet-909	87	44	)	)	PUNCT
admet-909	87	45	;	;	PUNCT
admet-909	87	46	and	and	CCONJ
admet-909	87	47	vd	vd	NOUN
admet-909	87	48	(	(	PUNCT
admet-909	87	49	l	l	NOUN
admet-909	87	50	)	)	PUNCT
admet-909	87	51	was	be	AUX
admet-909	87	52	7.6	7.6	NUM
admet-909	87	53	(	(	PUNCT
admet-909	87	54	0.2	0.2	NUM
admet-909	87	55	)	)	PUNCT
admet-909	87	56	.	.	PUNCT
admet-909	88	1	patients	patient	NOUN
admet-909	88	2	with	with	ADP
admet-909	88	3	cmax	cmax	NOUN
admet-909	88	4	and	and	CCONJ
admet-909	88	5	elimination	elimination	NOUN
admet-909	88	6	rate	rate	NOUN
admet-909	88	7	outside	outside	ADP
admet-909	88	8	the	the	DET
admet-909	88	9	mean+1.96	mean+1.96	PROPN
admet-909	88	10	sd	sd	NOUN
admet-909	88	11	had	have	VERB
admet-909	88	12	significantly	significantly	ADV
admet-909	88	13	lower	low	ADJ
admet-909	88	14	wsi	wsi	NOUN
admet-909	88	15	and	and	CCONJ
admet-909	88	16	higher	high	ADJ
admet-909	88	17	wcm	wcm	NOUN
admet-909	88	18	.	.	PUNCT
admet-909	89	1	significant	significant	ADJ
admet-909	89	2	correlations	correlation	NOUN
admet-909	89	3	were	be	AUX
admet-909	89	4	observed	observe	VERB
admet-909	89	5	between	between	ADP
admet-909	89	6	cmax	cmax	NOUN
admet-909	89	7	with	with	ADP
admet-909	89	8	cl	cl	NOUN
admet-909	89	9	,	,	PUNCT
admet-909	89	10	vd	vd	NOUN
admet-909	89	11	,	,	PUNCT
admet-909	89	12	and	and	CCONJ
admet-909	89	13	k	k	PROPN
admet-909	89	14	of	of	ADP
admet-909	89	15	warfarin	warfarin	NOUN
admet-909	89	16	.	.	PUNCT
admet-909	90	1	significant	significant	ADJ
admet-909	90	2	correlations	correlation	NOUN
admet-909	90	3	were	be	AUX
admet-909	90	4	also	also	ADV
admet-909	90	5	observed	observe	VERB
admet-909	90	6	between	between	ADP
admet-909	90	7	cl	cl	NOUN
admet-909	90	8	and	and	CCONJ
admet-909	90	9	vd	vd	NOUN
admet-909	90	10	of	of	ADP
admet-909	90	11	warfarin	warfarin	NOUN
admet-909	90	12	with	with	ADP
admet-909	90	13	liver	liver	NOUN
admet-909	90	14	weight	weight	NOUN
admet-909	90	15	of	of	ADP
admet-909	90	16	the	the	DET
admet-909	90	17	study	study	NOUN
admet-909	90	18	participants	participant	NOUN
admet-909	90	19	.	.	PUNCT
admet-909	91	1	the	the	DET
admet-909	91	2	pharmacokinetic	pharmacokinetic	ADJ
admet-909	91	3	parameters	parameter	NOUN
admet-909	91	4	of	of	ADP
admet-909	91	5	racemic	racemic	ADJ
admet-909	91	6	warfarin	warfarin	NOUN
admet-909	91	7	observed	observe	VERB
admet-909	91	8	in	in	ADP
admet-909	91	9	the	the	DET
admet-909	91	10	present	present	ADJ
admet-909	91	11	study	study	NOUN
admet-909	91	12	is	be	AUX
admet-909	91	13	like	like	ADP
admet-909	91	14	other	other	ADJ
admet-909	91	15	populations	population	NOUN
admet-909	91	16	[	[	X
admet-909	91	17	14	14	NUM
admet-909	91	18	]	]	PUNCT
admet-909	91	19	.	.	PUNCT
admet-909	92	1	although	although	SCONJ
admet-909	92	2	it	it	PRON
admet-909	92	3	would	would	AUX
admet-909	92	4	be	be	AUX
admet-909	92	5	better	well	ADJ
admet-909	92	6	to	to	PART
admet-909	92	7	measure	measure	VERB
admet-909	92	8	sand	sand	NOUN
admet-909	92	9	rwarfarin	rwarfarin	NOUN
admet-909	92	10	concentrations	concentration	NOUN
admet-909	92	11	,	,	PUNCT
admet-909	92	12	the	the	DET
admet-909	92	13	clinical	clinical	ADJ
admet-909	92	14	relevance	relevance	NOUN
admet-909	92	15	of	of	ADP
admet-909	92	16	estimating	estimate	VERB
admet-909	92	17	enantiomers	enantiomer	NOUN
admet-909	92	18	is	be	AUX
admet-909	92	19	limited	limit	VERB
admet-909	92	20	.	.	PUNCT
admet-909	93	1	ours	ours	PRON
admet-909	93	2	is	be	AUX
admet-909	93	3	the	the	DET
admet-909	93	4	first	first	ADJ
admet-909	93	5	study	study	NOUN
admet-909	93	6	exploring	explore	VERB
admet-909	93	7	the	the	DET
admet-909	93	8	relationship	relationship	NOUN
admet-909	93	9	between	between	ADP
admet-909	93	10	pharmacokinetic	pharmacokinetic	ADJ
admet-909	93	11	parameters	parameter	NOUN
admet-909	93	12	and	and	CCONJ
admet-909	93	13	wsi	wsi	PROPN
admet-909	93	14	and	and	CCONJ
admet-909	93	15	wcm	wcm	NOUN
admet-909	93	16	(	(	PUNCT
admet-909	93	17	the	the	DET
admet-909	93	18	pharmacodynamic	pharmacodynamic	ADJ
admet-909	93	19	parameters	parameter	NOUN
admet-909	93	20	)	)	PUNCT
admet-909	93	21	.	.	PUNCT
admet-909	94	1	lower	low	ADJ
admet-909	94	2	wsi	wsi	PROPN
admet-909	94	3	is	be	AUX
admet-909	94	4	corroborated	corroborate	VERB
admet-909	94	5	with	with	ADP
admet-909	94	6	warfarin	warfarin	NOUN
admet-909	94	7	resistance	resistance	NOUN
admet-909	94	8	.	.	PUNCT
admet-909	95	1	genotyping	genotyping	NOUN
admet-909	95	2	of	of	ADP
admet-909	95	3	vitamin	vitamin	NOUN
admet-909	95	4	k	k	X
admet-909	95	5	epoxide	epoxide	NOUN
admet-909	95	6	reductase	reductase	NOUN
admet-909	95	7	complex	complex	NOUN
admet-909	95	8	in	in	ADP
admet-909	95	9	our	our	PRON
admet-909	95	10	population	population	NOUN
admet-909	95	11	might	might	AUX
admet-909	95	12	provide	provide	VERB
admet-909	95	13	a	a	DET
admet-909	95	14	clue	clue	NOUN
admet-909	95	15	towards	towards	ADP
admet-909	95	16	the	the	DET
admet-909	95	17	prevalence	prevalence	NOUN
admet-909	95	18	and	and	CCONJ
admet-909	95	19	depth	depth	NOUN
admet-909	95	20	of	of	ADP
admet-909	95	21	warfarin	warfarin	NOUN
admet-909	95	22	resistance	resistance	NOUN
admet-909	95	23	.	.	PUNCT
admet-909	96	1	the	the	DET
admet-909	96	2	present	present	ADJ
admet-909	96	3	study	study	NOUN
admet-909	96	4	is	be	AUX
admet-909	96	5	also	also	ADV
admet-909	96	6	the	the	DET
admet-909	96	7	first	first	ADJ
admet-909	96	8	in	in	ADP
admet-909	96	9	exploring	explore	VERB
admet-909	96	10	the	the	DET
admet-909	96	11	relationship	relationship	NOUN
admet-909	96	12	between	between	ADP
admet-909	96	13	liver	liver	NOUN
admet-909	96	14	weight	weight	NOUN
admet-909	96	15	and	and	CCONJ
admet-909	96	16	pharmacokinetic	pharmacokinetic	ADJ
admet-909	96	17	parameters	parameter	NOUN
admet-909	96	18	of	of	ADP
admet-909	96	19	warfarin	warfarin	NOUN
admet-909	96	20	.	.	PUNCT
admet-909	97	1	though	though	ADV
admet-909	97	2	,	,	PUNCT
admet-909	97	3	liver	liver	NOUN
admet-909	97	4	weight	weight	NOUN
admet-909	97	5	has	have	AUX
admet-909	97	6	been	be	AUX
admet-909	97	7	argued	argue	VERB
admet-909	97	8	to	to	PART
admet-909	97	9	be	be	AUX
admet-909	97	10	a	a	DET
admet-909	97	11	better	well	ADJ
admet-909	97	12	corroborator	corroborator	NOUN
admet-909	97	13	of	of	ADP
admet-909	97	14	pharmacokinetic	pharmacokinetic	ADJ
admet-909	97	15	parameters	parameter	NOUN
admet-909	97	16	in	in	ADP
admet-909	97	17	children	child	NOUN
admet-909	97	18	,	,	PUNCT
admet-909	97	19	[	[	X
admet-909	97	20	15	15	NUM
admet-909	97	21	]	]	X
admet-909	97	22	its	its	PRON
admet-909	97	23	relationship	relationship	NOUN
admet-909	97	24	in	in	ADP
admet-909	97	25	adults	adult	NOUN
admet-909	97	26	has	have	AUX
admet-909	97	27	not	not	PART
admet-909	97	28	been	be	AUX
admet-909	97	29	studied	study	VERB
admet-909	97	30	.	.	PUNCT
admet-909	98	1	the	the	DET
admet-909	98	2	study	study	NOUN
admet-909	98	3	is	be	AUX
admet-909	98	4	limited	limit	VERB
admet-909	98	5	in	in	ADP
admet-909	98	6	not	not	PART
admet-909	98	7	validating	validate	VERB
admet-909	98	8	the	the	DET
admet-909	98	9	pharmacokinetic	pharmacokinetic	ADJ
admet-909	98	10	parameters	parameter	NOUN
admet-909	98	11	using	use	VERB
admet-909	98	12	real	real	ADJ
admet-909	98	13	-	-	PUNCT
admet-909	98	14	time	time	NOUN
admet-909	98	15	measurements	measurement	NOUN
admet-909	98	16	of	of	ADP
admet-909	98	17	plasma	plasma	NOUN
admet-909	98	18	warfarin	warfarin	NOUN
admet-909	98	19	concentrations	concentration	NOUN
admet-909	98	20	.	.	PUNCT
admet-909	99	1	to	to	PART
admet-909	99	2	conclude	conclude	VERB
admet-909	99	3	,	,	PUNCT
admet-909	99	4	we	we	PRON
admet-909	99	5	predicted	predict	VERB
admet-909	99	6	pharmacokinetic	pharmacokinetic	ADJ
admet-909	99	7	parameters	parameter	NOUN
admet-909	99	8	of	of	ADP
admet-909	99	9	warfarin	warfarin	NOUN
admet-909	99	10	from	from	ADP
admet-909	99	11	the	the	DET
admet-909	99	12	validated	validate	VERB
admet-909	99	13	pharmacokinetic	pharmacokinetic	ADJ
admet-909	99	14	-	-	PUNCT
admet-909	99	15	pharmacodynamic	pharmacodynamic	ADJ
admet-909	99	16	model	model	NOUN
admet-909	99	17	in	in	ADP
admet-909	99	18	our	our	PRON
admet-909	99	19	population	population	NOUN
admet-909	99	20	.	.	PUNCT
admet-909	100	1	more	more	ADJ
admet-909	100	2	studies	study	NOUN
admet-909	100	3	are	be	AUX
admet-909	100	4	needed	need	VERB
admet-909	100	5	exploring	explore	VERB
admet-909	100	6	the	the	DET
admet-909	100	7	relationship	relationship	NOUN
admet-909	100	8	between	between	ADP
admet-909	100	9	various	various	ADJ
admet-909	100	10	pharmacodynamic	pharmacodynamic	ADJ
admet-909	100	11	indices	index	NOUN
admet-909	100	12	of	of	ADP
admet-909	100	13	warfarin	warfarin	NOUN
admet-909	100	14	and	and	CCONJ
admet-909	100	15	pharmacokinetic	pharmacokinetic	ADJ
admet-909	100	16	parameters	parameter	NOUN
admet-909	100	17	of	of	ADP
admet-909	100	18	warfarin	warfarin	NOUN
admet-909	100	19	.	.	PUNCT
admet-909	101	1	acknowledgements	acknowledgement	NOUN
admet-909	101	2	:	:	PUNCT
admet-909	101	3	we	we	PRON
admet-909	101	4	thank	thank	VERB
admet-909	101	5	research	research	NOUN
admet-909	101	6	technical	technical	ADJ
admet-909	101	7	support	support	NOUN
admet-909	101	8	team	team	NOUN
admet-909	101	9	,	,	PUNCT
admet-909	101	10	ministry	ministry	PROPN
admet-909	101	11	of	of	ADP
admet-909	101	12	health	health	PROPN
admet-909	101	13	,	,	PUNCT
admet-909	101	14	kingdom	kingdom	NOUN
admet-909	101	15	of	of	ADP
admet-909	101	16	bahrain	bahrain	NOUN
admet-909	101	17	for	for	ADP
admet-909	101	18	their	their	PRON
admet-909	101	19	ethics	ethic	NOUN
admet-909	101	20	approval	approval	NOUN
admet-909	101	21	of	of	ADP
admet-909	101	22	this	this	DET
admet-909	101	23	study	study	NOUN
admet-909	101	24	.	.	PUNCT
admet-909	102	1	we	we	PRON
admet-909	102	2	are	be	AUX
admet-909	102	3	grateful	grateful	ADJ
admet-909	102	4	to	to	ADP
admet-909	102	5	agu	agu	VERB
admet-909	102	6	rcsi	rcsi	VERB
admet-909	102	7	steering	steering	NOUN
admet-909	102	8	committee	committee	NOUN
admet-909	102	9	for	for	ADP
admet-909	102	10	their	their	PRON
admet-909	102	11	support	support	NOUN
admet-909	102	12	in	in	ADP
admet-909	102	13	carrying	carry	VERB
admet-909	102	14	out	out	ADP
admet-909	102	15	this	this	DET
admet-909	102	16	research	research	NOUN
admet-909	102	17	study	study	NOUN
admet-909	102	18	.	.	PUNCT
admet-909	103	1	conflict	conflict	NOUN
admet-909	103	2	of	of	ADP
admet-909	103	3	interest	interest	NOUN
admet-909	103	4	:	:	PUNCT
admet-909	103	5	none	none	NOUN
admet-909	103	6	funding	funding	NOUN
admet-909	103	7	:	:	PUNCT
admet-909	103	8	the	the	DET
admet-909	103	9	study	study	NOUN
admet-909	103	10	was	be	AUX
admet-909	103	11	carried	carry	VERB
admet-909	103	12	out	out	ADP
admet-909	103	13	as	as	ADP
admet-909	103	14	a	a	DET
admet-909	103	15	part	part	NOUN
admet-909	103	16	of	of	ADP
admet-909	103	17	the	the	DET
admet-909	103	18	warfarin	warfarin	NOUN
admet-909	103	19	pharmacogenomics	pharmacogenomic	NOUN
admet-909	103	20	study	study	NOUN
admet-909	103	21	that	that	PRON
admet-909	103	22	was	be	AUX
admet-909	103	23	funded	fund	VERB
admet-909	103	24	by	by	ADP
admet-909	103	25	agu	agu	NOUN
admet-909	103	26	rcsi	rcsi	VERB
admet-909	103	27	joint	joint	ADJ
admet-909	103	28	grant	grant	NOUN
admet-909	103	29	with	with	ADP
admet-909	103	30	grant	grant	NOUN
admet-909	103	31	number	number	NOUN
admet-909	103	32	2019	2019	NUM
admet-909	103	33	-	-	SYM
admet-909	103	34	02	02	NUM
admet-909	103	35	.	.	PUNCT
admet-909	104	1	references	reference	NOUN
admet-909	104	2	[	[	X
admet-909	104	3	1	1	NUM
admet-909	104	4	]	]	PUNCT
admet-909	104	5	k.	k.	PROPN
admet-909	104	6	harter	harter	PROPN
admet-909	104	7	,	,	PUNCT
admet-909	104	8	m.	m.	PROPN
admet-909	104	9	levine	levine	PROPN
admet-909	104	10	,	,	PUNCT
admet-909	104	11	s.o	s.o	PROPN
admet-909	104	12	.	.	PROPN
admet-909	104	13	henderson	henderson	PROPN
admet-909	104	14	.	.	PUNCT
admet-909	105	1	anticoagulation	anticoagulation	NOUN
admet-909	105	2	drug	drug	NOUN
admet-909	105	3	therapy	therapy	NOUN
admet-909	105	4	:	:	PUNCT
admet-909	105	5	a	a	DET
admet-909	105	6	review	review	NOUN
admet-909	105	7	.	.	PUNCT
admet-909	106	1	west	west	PROPN
admet-909	106	2	.	.	PUNCT
admet-909	107	1	j.	j.	PROPN
admet-909	107	2	emerg	emerg	PROPN
admet-909	107	3	.	.	PUNCT
admet-909	108	1	med	med	PROPN
admet-909	108	2	.	.	PUNCT
admet-909	109	1	16(1	16(1	X
admet-909	109	2	)	)	PUNCT
admet-909	109	3	(	(	PUNCT
admet-909	109	4	2015	2015	NUM
admet-909	109	5	)	)	PUNCT
admet-909	109	6	11	11	NUM
admet-909	109	7	-	-	SYM
admet-909	109	8	17	17	NUM
admet-909	109	9	.	.	PUNCT
admet-909	110	1	[	[	X
admet-909	110	2	2	2	NUM
admet-909	110	3	]	]	PUNCT
admet-909	110	4	c.	c.	PROPN
admet-909	110	5	lv	lv	PROPN
admet-909	110	6	,	,	PUNCT
admet-909	110	7	c.	c.	PROPN
admet-909	110	8	liu	liu	PROPN
admet-909	110	9	,	,	PUNCT
admet-909	110	10	z.	z.	PROPN
admet-909	110	11	yao	yao	PROPN
admet-909	110	12	et	et	PROPN
admet-909	110	13	al	al	PROPN
admet-909	110	14	.	.	PUNCT
admet-909	111	1	the	the	DET
admet-909	111	2	clinical	clinical	ADJ
admet-909	111	3	pharmacokinetics	pharmacokinetic	NOUN
admet-909	111	4	and	and	CCONJ
admet-909	111	5	pharmacodynamics	pharmacodynamic	NOUN
admet-909	111	6	of	of	ADP
admet-909	111	7	warfarin	warfarin	NOUN
admet-909	111	8	when	when	SCONJ
admet-909	111	9	combined	combine	VERB
admet-909	111	10	with	with	ADP
admet-909	111	11	compound	compound	NOUN
admet-909	111	12	danshen	danshen	NOUN
admet-909	111	13	:	:	PUNCT
admet-909	111	14	a	a	DET
admet-909	111	15	case	case	NOUN
admet-909	111	16	study	study	NOUN
admet-909	111	17	for	for	ADP
admet-909	111	18	combined	combined	ADJ
admet-909	111	19	treatment	treatment	NOUN
admet-909	111	20	of	of	ADP
admet-909	111	21	coronary	coronary	ADJ
admet-909	111	22	heart	heart	NOUN
admet-909	111	23	diseases	disease	NOUN
admet-909	111	24	with	with	ADP
admet-909	111	25	atrial	atrial	ADJ
admet-909	111	26	fibrillation	fibrillation	NOUN
admet-909	111	27	.	.	PUNCT
admet-909	112	1	front	front	ADJ
admet-909	112	2	pharmacol	pharmacol	PROPN
admet-909	112	3	.	.	PROPN
admet-909	113	1	8	8	NUM
admet-909	113	2	(	(	PUNCT
admet-909	113	3	2017	2017	NUM
admet-909	113	4	)	)	PUNCT
admet-909	113	5	826	826	NUM
admet-909	113	6	.	.	PUNCT
admet-909	114	1	[	[	X
admet-909	114	2	3	3	NUM
admet-909	114	3	]	]	X
admet-909	114	4	d.a	d.a	PROPN
admet-909	114	5	.	.	PROPN
admet-909	114	6	barnette	barnette	PROPN
admet-909	114	7	,	,	PUNCT
admet-909	114	8	b.p	b.p	PROPN
admet-909	114	9	.	.	PROPN
admet-909	114	10	johnson	johnson	PROPN
admet-909	114	11	,	,	PUNCT
admet-909	114	12	d.l	d.l	PROPN
admet-909	114	13	.	.	PROPN
admet-909	114	14	pouncey	pouncey	PROPN
admet-909	115	1	et	et	PROPN
admet-909	115	2	al	al	PROPN
admet-909	115	3	.	.	PROPN
admet-909	115	4	stereospecific	stereospecific	ADJ
admet-909	115	5	metabolism	metabolism	NOUN
admet-909	115	6	of	of	ADP
admet-909	115	7	rand	rand	NOUN
admet-909	115	8	s	s	NOUN
admet-909	115	9	-	-	NOUN
admet-909	115	10	warfarin	warfarin	NOUN
admet-909	115	11	by	by	ADP
admet-909	115	12	human	human	ADJ
admet-909	115	13	hepatic	hepatic	ADJ
admet-909	115	14	cytosolic	cytosolic	NOUN
admet-909	115	15	reductases	reductase	NOUN
admet-909	115	16	.	.	PUNCT
admet-909	116	1	drug	drug	NOUN
admet-909	116	2	metab	metab	NOUN
admet-909	116	3	.	.	PUNCT
admet-909	117	1	dispos	dispos	PROPN
admet-909	117	2	.	.	PUNCT
admet-909	118	1	45(9	45(9	NUM
admet-909	118	2	)	)	PUNCT
admet-909	118	3	(	(	PUNCT
admet-909	118	4	2017	2017	NUM
admet-909	118	5	)	)	PUNCT
admet-909	118	6	1000	1000	NUM
admet-909	118	7	-	-	SYM
admet-909	118	8	1007	1007	NUM
admet-909	118	9	.	.	PUNCT
admet-909	119	1	[	[	X
admet-909	119	2	4	4	X
admet-909	119	3	]	]	X
admet-909	119	4	j.	j.	PROPN
admet-909	119	5	bubp	bubp	PROPN
admet-909	119	6	,	,	PUNCT
admet-909	119	7	r.	r.	PROPN
admet-909	119	8	coleman	coleman	PROPN
admet-909	119	9	,	,	PUNCT
admet-909	119	10	d.	d.	PROPN
admet-909	119	11	mungall	mungall	PROPN
admet-909	119	12	,	,	PUNCT
admet-909	119	13	g.	g.	PROPN
admet-909	119	14	raskob	raskob	PROPN
admet-909	119	15	,	,	PUNCT
admet-909	119	16	r.	r.	PROPN
admet-909	119	17	hull	hull	PROPN
admet-909	119	18	.	.	PUNCT
admet-909	120	1	comparison	comparison	NOUN
admet-909	120	2	of	of	ADP
admet-909	120	3	warfarin	warfarin	NOUN
admet-909	120	4	pharmacodynamic	pharmacodynamic	ADJ
admet-909	120	5	modelpredictions	modelprediction	NOUN
admet-909	120	6	using	use	VERB
admet-909	120	7	manchester	manchester	PROPN
admet-909	120	8	comparative	comparative	ADJ
admet-909	120	9	reagent	reagent	NOUN
admet-909	120	10	vs	vs	ADP
admet-909	120	11	simplastin	simplastin	ADJ
admet-909	120	12	reagent	reagent	NOUN
admet-909	120	13	.	.	PUNCT
admet-909	121	1	clin	clin	PROPN
admet-909	121	2	.	.	PUNCT
admet-909	122	1	pharmacol	pharmacol	PROPN
admet-909	122	2	.	.	PUNCT
admet-909	123	1	ther	ther	PROPN
admet-909	123	2	.	.	PUNCT
admet-909	124	1	47	47	NUM
admet-909	124	2	(	(	PUNCT
admet-909	124	3	1990	1990	NUM
admet-909	124	4	)	)	PUNCT
admet-909	124	5	157	157	NUM
admet-909	124	6	.	.	PUNCT
admet-909	125	1	[	[	X
admet-909	125	2	5	5	NUM
admet-909	125	3	]	]	X
admet-909	125	4	d.a	d.a	PROPN
admet-909	125	5	.	.	PROPN
admet-909	125	6	lane	lane	PROPN
admet-909	125	7	,	,	PUNCT
admet-909	125	8	g.y	g.y	PROPN
admet-909	125	9	.	.	PUNCT
admet-909	125	10	lip	lip	PROPN
admet-909	125	11	.	.	PUNCT
admet-909	126	1	use	use	NOUN
admet-909	126	2	of	of	ADP
admet-909	126	3	the	the	DET
admet-909	126	4	cha(2)ds(2)-vasc	cha(2)ds(2)-vasc	PROPN
admet-909	126	5	and	and	CCONJ
admet-909	126	6	has	have	AUX
admet-909	126	7	-	-	PUNCT
admet-909	126	8	bled	bleed	VERB
admet-909	126	9	scores	score	NOUN
admet-909	126	10	to	to	PART
admet-909	126	11	aid	aid	VERB
admet-909	126	12	decision	decision	NOUN
admet-909	126	13	making	make	VERB
admet-909	126	14	for	for	ADP
admet-909	126	15	thromboprophylaxis	thromboprophylaxis	NOUN
admet-909	126	16	in	in	ADP
admet-909	126	17	nonvalvular	nonvalvular	ADJ
admet-909	126	18	atrial	atrial	ADJ
admet-909	126	19	fibrillation	fibrillation	NOUN
admet-909	126	20	.	.	PUNCT
admet-909	127	1	circulation	circulation	NOUN
admet-909	127	2	126	126	NUM
admet-909	127	3	(	(	PUNCT
admet-909	127	4	2012	2012	NUM
admet-909	127	5	)	)	PUNCT
admet-909	127	6	860	860	NUM
admet-909	127	7	-	-	SYM
admet-909	127	8	865	865	NUM
admet-909	127	9	.	.	PUNCT
admet-909	128	1	[	[	X
admet-909	128	2	6	6	NUM
admet-909	128	3	]	]	X
admet-909	128	4	g.y	g.y	PROPN
admet-909	128	5	.	.	PUNCT
admet-909	128	6	lip	lip	PROPN
admet-909	128	7	.	.	PUNCT
admet-909	129	1	atrial	atrial	ADJ
admet-909	129	2	fibrillation	fibrillation	NOUN
admet-909	129	3	and	and	CCONJ
admet-909	129	4	stroke	stroke	NOUN
admet-909	129	5	prevention	prevention	NOUN
admet-909	129	6	:	:	PUNCT
admet-909	129	7	brief	brief	ADJ
admet-909	129	8	observations	observation	NOUN
admet-909	129	9	on	on	ADP
admet-909	129	10	the	the	DET
admet-909	129	11	last	last	ADJ
admet-909	129	12	decade	decade	NOUN
admet-909	129	13	.	.	PUNCT
admet-909	130	1	expert	expert	PROPN
admet-909	130	2	rev	rev	PROPN
admet-909	130	3	.	.	PROPN
admet-909	130	4	cardiovasc	cardiovasc	PROPN
admet-909	130	5	.	.	PUNCT
admet-909	131	1	ther	ther	PROPN
admet-909	131	2	.	.	PUNCT
admet-909	132	1	12	12	NUM
admet-909	132	2	(	(	PUNCT
admet-909	132	3	2014	2014	NUM
admet-909	132	4	)	)	PUNCT
admet-909	132	5	403	403	NUM
admet-909	132	6	-	-	SYM
admet-909	132	7	406	406	NUM
admet-909	132	8	.	.	PUNCT
admet-909	133	1	admet	admet	PROPN
admet-909	133	2	&	&	CCONJ
admet-909	133	3	dmpk	dmpk	PROPN
admet-909	133	4	9(2	9(2	NUM
admet-909	133	5	)	)	PUNCT
admet-909	133	6	(	(	PUNCT
admet-909	133	7	2021	2021	NUM
admet-909	133	8	)	)	PUNCT
admet-909	133	9	143	143	NUM
admet-909	133	10	-	-	SYM
admet-909	133	11	149	149	NUM
admet-909	133	12	warfarin	warfarin	NOUN
admet-909	133	13	pharmacokinetics	pharmacokinetic	NOUN
admet-909	133	14	doi	doi	NOUN
admet-909	133	15	:	:	PUNCT
admet-909	133	16	https://dx.doi.org/10.5599/admet.909	https://dx.doi.org/10.5599/admet.909	NOUN
admet-909	133	17	149	149	NUM
admet-909	133	18	[	[	X
admet-909	133	19	7	7	X
admet-909	133	20	]	]	X
admet-909	133	21	c.	c.	PROPN
admet-909	133	22	de	de	PROPN
admet-909	133	23	fátima	fátima	PROPN
admet-909	133	24	colet	colet	NOUN
admet-909	133	25	,	,	PUNCT
admet-909	133	26	a.t	a.t	PROPN
admet-909	133	27	.	.	PROPN
admet-909	133	28	amador	amador	PROPN
admet-909	133	29	,	,	PUNCT
admet-909	133	30	i.	i.	PROPN
admet-909	133	31	heineck	heineck	PROPN
admet-909	133	32	.	.	PUNCT
admet-909	134	1	drug	drug	NOUN
admet-909	134	2	interactions	interaction	NOUN
admet-909	134	3	and	and	CCONJ
admet-909	134	4	adverse	adverse	ADJ
admet-909	134	5	events	event	NOUN
admet-909	134	6	in	in	ADP
admet-909	134	7	a	a	DET
admet-909	134	8	cohort	cohort	NOUN
admet-909	134	9	of	of	ADP
admet-909	134	10	warfarin	warfarin	NOUN
admet-909	134	11	users	user	NOUN
admet-909	134	12	attending	attend	VERB
admet-909	134	13	public	public	ADJ
admet-909	134	14	health	health	NOUN
admet-909	134	15	clinics	clinic	NOUN
admet-909	134	16	.	.	PUNCT
admet-909	135	1	international	international	ADJ
admet-909	135	2	journal	journal	NOUN
admet-909	135	3	of	of	ADP
admet-909	135	4	cardiovascular	cardiovascular	ADJ
admet-909	135	5	sciences	science	NOUN
admet-909	135	6	32	32	NUM
admet-909	135	7	(	(	PUNCT
admet-909	135	8	2019	2019	NUM
admet-909	135	9	)	)	PUNCT
admet-909	135	10	110	110	NUM
admet-909	135	11	-	-	SYM
admet-909	135	12	117	117	NUM
admet-909	135	13	.	.	PUNCT
admet-909	136	1	[	[	X
admet-909	136	2	8	8	NUM
admet-909	136	3	]	]	SYM
admet-909	136	4	atrial	atrial	ADJ
admet-909	136	5	fibrillation	fibrillation	NOUN
admet-909	136	6	.	.	PUNCT
admet-909	137	1	anticoagulation	anticoagulation	NOUN
admet-909	137	2	control	control	NOUN
admet-909	137	3	.	.	PUNCT
admet-909	138	1	national	national	PROPN
admet-909	138	2	institute	institute	PROPN
admet-909	138	3	for	for	ADP
admet-909	138	4	health	health	NOUN
admet-909	138	5	and	and	CCONJ
admet-909	138	6	care	care	PROPN
admet-909	138	7	excellence	excellence	PROPN
admet-909	138	8	(	(	PUNCT
admet-909	138	9	nice	nice	ADJ
admet-909	138	10	)	)	PUNCT
admet-909	138	11	.	.	PUNCT
admet-909	139	1	available	available	ADJ
admet-909	139	2	at	at	ADP
admet-909	139	3	https://www.nice.org.uk/guidance/qs93/chapter/quality-statement-4-anticoagulationcontrol	https://www.nice.org.uk/guidance/qs93/chapter/quality-statement-4-anticoagulationcontrol	PROPN
admet-909	139	4	(	(	PUNCT
admet-909	139	5	accessed	access	VERB
admet-909	139	6	on	on	ADP
admet-909	139	7	15	15	NUM
admet-909	139	8	july	july	NOUN
admet-909	139	9	2020	2020	NUM
admet-909	139	10	)	)	PUNCT
admet-909	139	11	.	.	PUNCT
admet-909	140	1	[	[	X
admet-909	140	2	9	9	X
admet-909	140	3	]	]	PUNCT
admet-909	140	4	k.	k.	NOUN
admet-909	141	1	sridharan	sridharan	PROPN
admet-909	141	2	,	,	PUNCT
admet-909	141	3	r.	r.	PROPN
admet-909	141	4	al	al	PROPN
admet-909	141	5	banna	banna	PROPN
admet-909	141	6	,	,	PUNCT
admet-909	141	7	a.m.	a.m.	NOUN
admet-909	141	8	qader	qader	PROPN
admet-909	141	9	,	,	PUNCT
admet-909	141	10	a	a	DET
admet-909	141	11	hussain	hussain	NOUN
admet-909	141	12	.	.	PUNCT
admet-909	142	1	evaluation	evaluation	NOUN
admet-909	142	2	of	of	ADP
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admet-909	142	4	-	-	ADJ
admet-909	142	5	patient	patient	ADJ
admet-909	142	6	variability	variability	NOUN
admet-909	142	7	in	in	ADP
admet-909	142	8	the	the	DET
admet-909	142	9	pharmacodynamic	pharmacodynamic	ADJ
admet-909	142	10	indices	index	NOUN
admet-909	142	11	of	of	ADP
admet-909	142	12	warfarin	warfarin	NOUN
admet-909	142	13	.	.	PUNCT
admet-909	143	1	expert	expert	PROPN
admet-909	143	2	rev	rev	PROPN
admet-909	143	3	.	.	PROPN
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admet-909	143	5	.	.	PUNCT
admet-909	144	1	ther	ther	PROPN
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admet-909	145	1	18(11	18(11	NUM
admet-909	145	2	)	)	PUNCT
admet-909	145	3	(	(	PUNCT
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admet-909	145	5	)	)	PUNCT
admet-909	145	6	835	835	NUM
admet-909	145	7	-	-	SYM
admet-909	145	8	840	840	NUM
admet-909	145	9	.	.	PUNCT
admet-909	146	1	doi	doi	NOUN
admet-909	146	2	:	:	PUNCT
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admet-909	147	2	.	.	PUNCT
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admet-909	148	2	10	10	NUM
admet-909	148	3	]	]	X
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admet-909	148	5	.	.	PROPN
admet-909	148	6	fihn	fihn	PROPN
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admet-909	148	9	.	.	PROPN
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admet-909	148	43	acenocoumarol	acenocoumarol	NOUN
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admet-909	148	46	.	.	PUNCT
admet-909	149	1	thromb	thromb	PROPN
admet-909	149	2	haemost	haemost	PROPN
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admet-909	150	2	)	)	PUNCT
admet-909	150	3	(	(	PUNCT
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admet-909	150	5	)	)	PUNCT
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admet-909	150	7	-	-	SYM
admet-909	150	8	266	266	NUM
admet-909	150	9	.	.	PUNCT
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admet-909	151	2	11	11	NUM
admet-909	151	3	]	]	PUNCT
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admet-909	152	5	warfarin	warfarin	NOUN
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admet-909	152	8	.	.	PUNCT
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admet-909	153	2	.	.	PUNCT
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admet-909	154	2	.	.	PUNCT
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admet-909	156	6	)	)	PUNCT
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admet-909	156	8	.	.	PUNCT
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admet-909	158	11	.	.	PUNCT
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admet-909	160	5	)	)	PUNCT
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admet-909	160	7	-	-	SYM
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admet-909	160	9	.	.	PUNCT
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admet-909	161	5	pk	pk	PROPN
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admet-909	161	9	.	.	PUNCT
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admet-909	162	2	at	at	ADP
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admet-909	162	10	20	20	NUM
admet-909	162	11	)	)	PUNCT
admet-909	162	12	.	.	PUNCT
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admet-909	163	9	,	,	PUNCT
admet-909	163	10	a.j	a.j	PROPN
admet-909	163	11	.	.	PROPN
admet-909	163	12	dietz	dietz	PROPN
admet-909	163	13	,	,	PUNCT
admet-909	163	14	d.	d.	PROPN
admet-909	163	15	kowalski	kowalski	PROPN
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admet-909	164	8	-	-	PUNCT
admet-909	164	9	drug	drug	NOUN
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admet-909	164	12	isavuconazole	isavuconazole	NOUN
admet-909	164	13	and	and	CCONJ
admet-909	164	14	warfarin	warfarin	NOUN
admet-909	164	15	in	in	ADP
admet-909	164	16	healthy	healthy	ADJ
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admet-909	165	2	.	.	PUNCT
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admet-909	166	2	.	.	PUNCT
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admet-909	166	4	dev	dev	PROPN
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admet-909	167	2	)	)	PUNCT
admet-909	168	1	(	(	PUNCT
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admet-909	168	3	)	)	PUNCT
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admet-909	168	5	-	-	SYM
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admet-909	169	3	]	]	X
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admet-909	169	5	takahashi	takahashi	PROPN
admet-909	169	6	,	,	PUNCT
admet-909	169	7	s.	s.	PROPN
admet-909	169	8	ishikawa	ishikawa	PROPN
admet-909	169	9	,	,	PUNCT
admet-909	169	10	s.	s.	PROPN
admet-909	169	11	nomoto	nomoto	PROPN
admet-909	169	12	,	,	PUNCT
admet-909	169	13	y.	y.	PROPN
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admet-909	169	19	t.	t.	PROPN
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admet-909	169	21	,	,	PUNCT
admet-909	169	22	s.	s.	PROPN
admet-909	169	23	kimura	kimura	PROPN
admet-909	169	24	,	,	PUNCT
admet-909	169	25	m.	m.	PROPN
admet-909	169	26	kanamori	kanamori	PROPN
admet-909	169	27	,	,	PUNCT
admet-909	169	28	h.	h.	PROPN
admet-909	169	29	echizen	echizen	PROPN
admet-909	169	30	.	.	PUNCT
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admet-909	169	32	changes	change	NOUN
admet-909	169	33	in	in	ADP
admet-909	169	34	pharmacokinetics	pharmacokinetic	NOUN
admet-909	169	35	and	and	CCONJ
admet-909	169	36	pharmacodynamics	pharmacodynamic	NOUN
admet-909	169	37	of	of	ADP
admet-909	169	38	warfarin	warfarin	NOUN
admet-909	169	39	enantiomers	enantiomer	NOUN
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admet-909	170	1	clin	clin	PROPN
admet-909	170	2	.	.	PUNCT
admet-909	171	1	pharmacol	pharmacol	PROPN
admet-909	171	2	.	.	PUNCT
admet-909	172	1	ther	ther	PROPN
admet-909	172	2	.	.	PUNCT
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admet-909	173	3	(	(	PUNCT
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admet-909	173	5	)	)	PUNCT
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admet-909	173	7	-	-	SYM
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admet-909	176	2	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN