id	sid	tid	token	lemma	pos
admet-916	1	1	in	in	ADP
admet-916	1	2	vitro	vitro	X
admet-916	1	3	ph	ph	ADJ
admet-916	1	4	dependent	dependent	ADJ
admet-916	1	5	passive	passive	ADJ
admet-916	1	6	transport	transport	NOUN
admet-916	1	7	of	of	ADP
admet-916	1	8	ketoprofen	ketoprofen	NOUN
admet-916	1	9	and	and	CCONJ
admet-916	1	10	metformin	metformin	PROPN
admet-916	1	11	doi	doi	PROPN
admet-916	1	12	:	:	PUNCT
admet-916	1	13	http://dx.doi.org/10.5599/admet.916	http://dx.doi.org/10.5599/admet.916	PROPN
admet-916	1	14	57	57	NUM
admet-916	1	15	admet	admet	PROPN
admet-916	1	16	&	&	CCONJ
admet-916	1	17	dmpk	dmpk	PROPN
admet-916	1	18	9(1	9(1	NUM
admet-916	1	19	)	)	PUNCT
admet-916	1	20	(	(	PUNCT
admet-916	1	21	2021	2021	NUM
admet-916	1	22	)	)	PUNCT
admet-916	1	23	57	57	NUM
admet-916	1	24	-	-	SYM
admet-916	1	25	68	68	NUM
admet-916	1	26	;	;	PUNCT
admet-916	1	27	doi	doi	NOUN
admet-916	1	28	:	:	PUNCT
admet-916	1	29	https://doi.org/10.5599/admet.916	https://doi.org/10.5599/admet.916	NUM
admet-916	1	30	open	open	ADJ
admet-916	1	31	access	access	NOUN
admet-916	1	32	:	:	PUNCT
admet-916	1	33	issn	issn	PROPN
admet-916	1	34	:	:	PUNCT
admet-916	1	35	1848	1848	NUM
admet-916	1	36	-	-	SYM
admet-916	1	37	7718	7718	NUM
admet-916	1	38	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-916	1	39	original	original	ADJ
admet-916	1	40	scientific	scientific	ADJ
admet-916	1	41	paper	paper	NOUN
admet-916	1	42	in	in	ADP
admet-916	1	43	vitro	vitro	X
admet-916	1	44	ph	ph	ADJ
admet-916	1	45	dependent	dependent	ADJ
admet-916	1	46	passive	passive	ADJ
admet-916	1	47	transport	transport	NOUN
admet-916	1	48	of	of	ADP
admet-916	1	49	ketoprofen	ketoprofen	NOUN
admet-916	1	50	and	and	CCONJ
admet-916	1	51	metformin	metformin	PROPN
admet-916	1	52	alisa	alisa	PROPN
admet-916	1	53	elezović*1	elezović*1	PROPN
admet-916	1	54	,	,	PUNCT
admet-916	1	55	amina	amina	PROPN
admet-916	1	56	marić1	marić1	PROPN
admet-916	1	57	,	,	PUNCT
admet-916	1	58	amila	amila	PROPN
admet-916	1	59	biščević1	biščević1	PROPN
admet-916	1	60	,	,	PUNCT
admet-916	1	61	jasmina	jasmina	PROPN
admet-916	1	62	hadžiabdić1	hadžiabdić1	PROPN
admet-916	1	63	,	,	PUNCT
admet-916	1	64	selma	selma	PROPN
admet-916	1	65	škrbo2	škrbo2	PROPN
admet-916	1	66	,	,	PUNCT
admet-916	1	67	selma	selma	PROPN
admet-916	1	68	špirtović	špirtović	PROPN
admet-916	1	69	-	-	PUNCT
admet-916	1	70	halilović3	halilović3	NOUN
admet-916	1	71	,	,	PUNCT
admet-916	1	72	ognjenka	ognjenka	PROPN
admet-916	1	73	rahić1	rahić1	PROPN
admet-916	1	74	,	,	PUNCT
admet-916	1	75	edina	edina	PROPN
admet-916	1	76	vranić1	vranić1	PROPN
admet-916	1	77	,	,	PUNCT
admet-916	1	78	amar	amar	PROPN
admet-916	1	79	elezović4	elezović4	PROPN
admet-916	1	80	1	1	NUM
admet-916	1	81	department	department	NOUN
admet-916	1	82	of	of	ADP
admet-916	1	83	pharmaceutical	pharmaceutical	NOUN
admet-916	1	84	technology	technology	NOUN
admet-916	1	85	,	,	PUNCT
admet-916	1	86	faculty	faculty	NOUN
admet-916	1	87	of	of	ADP
admet-916	1	88	pharmacy	pharmacy	NOUN
admet-916	1	89	,	,	PUNCT
admet-916	1	90	university	university	PROPN
admet-916	1	91	of	of	ADP
admet-916	1	92	sarajevo	sarajevo	PROPN
admet-916	1	93	,	,	PUNCT
admet-916	1	94	zmaja	zmaja	PROPN
admet-916	1	95	od	od	PROPN
admet-916	1	96	bosne	bosne	PROPN
admet-916	1	97	8	8	NUM
admet-916	1	98	,	,	PUNCT
admet-916	1	99	71000	71000	NUM
admet-916	1	100	sarajevo	sarajevo	PROPN
admet-916	1	101	,	,	PUNCT
admet-916	1	102	bosnia	bosnia	PROPN
admet-916	1	103	and	and	CCONJ
admet-916	1	104	herzegovina	herzegovina	PROPN
admet-916	1	105	2	2	NUM
admet-916	1	106	department	department	NOUN
admet-916	1	107	of	of	ADP
admet-916	1	108	clinical	clinical	ADJ
admet-916	1	109	pharmacy	pharmacy	NOUN
admet-916	1	110	,	,	PUNCT
admet-916	1	111	faculty	faculty	NOUN
admet-916	1	112	of	of	ADP
admet-916	1	113	pharmacy	pharmacy	NOUN
admet-916	1	114	,	,	PUNCT
admet-916	1	115	university	university	PROPN
admet-916	1	116	of	of	ADP
admet-916	1	117	sarajevo	sarajevo	PROPN
admet-916	1	118	,	,	PUNCT
admet-916	1	119	zmaja	zmaja	PROPN
admet-916	1	120	od	od	PROPN
admet-916	1	121	bosne	bosne	PROPN
admet-916	1	122	8	8	NUM
admet-916	1	123	,	,	PUNCT
admet-916	1	124	71000	71000	NUM
admet-916	1	125	sarajevo	sarajevo	PROPN
admet-916	1	126	3	3	NUM
admet-916	1	127	department	department	NOUN
admet-916	1	128	of	of	ADP
admet-916	1	129	pharmaceutical	pharmaceutical	ADJ
admet-916	1	130	chemistry	chemistry	NOUN
admet-916	1	131	,	,	PUNCT
admet-916	1	132	faculty	faculty	NOUN
admet-916	1	133	of	of	ADP
admet-916	1	134	pharmacy	pharmacy	NOUN
admet-916	1	135	,	,	PUNCT
admet-916	1	136	university	university	PROPN
admet-916	1	137	of	of	ADP
admet-916	1	138	sarajevo	sarajevo	PROPN
admet-916	1	139	,	,	PUNCT
admet-916	1	140	zmaja	zmaja	PROPN
admet-916	1	141	od	od	PROPN
admet-916	1	142	bosne	bosne	PROPN
admet-916	1	143	8	8	NUM
admet-916	1	144	,	,	PUNCT
admet-916	1	145	71000	71000	NUM
admet-916	1	146	sarajevo	sarajevo	PROPN
admet-916	1	147	,	,	PUNCT
admet-916	1	148	bosnia	bosnia	PROPN
admet-916	1	149	and	and	CCONJ
admet-916	1	150	herzegovina	herzegovina	PROPN
admet-916	1	151	4	4	NUM
admet-916	1	152	control	control	NOUN
admet-916	1	153	laboratory	laboratory	NOUN
admet-916	1	154	of	of	ADP
admet-916	1	155	the	the	DET
admet-916	1	156	agency	agency	NOUN
admet-916	1	157	for	for	ADP
admet-916	1	158	medicinal	medicinal	ADJ
admet-916	1	159	products	product	NOUN
admet-916	1	160	and	and	CCONJ
admet-916	1	161	medical	medical	ADJ
admet-916	1	162	devices	device	NOUN
admet-916	1	163	,	,	PUNCT
admet-916	1	164	titova	titova	VERB
admet-916	1	165	9	9	NUM
admet-916	1	166	,	,	PUNCT
admet-916	1	167	71000	71000	NUM
admet-916	1	168	sarajevo	sarajevo	PROPN
admet-916	1	169	*	*	PUNCT
admet-916	1	170	corresponding	correspond	VERB
admet-916	1	171	author	author	NOUN
admet-916	1	172	:	:	PUNCT
admet-916	1	173	e	e	NOUN
admet-916	1	174	-	-	NOUN
admet-916	1	175	mail	mail	NOUN
admet-916	1	176	:	:	PUNCT
admet-916	1	177	alisa.elezovic@ffsa.unsa.ba	alisa.elezovic@ffsa.unsa.ba	PROPN
admet-916	1	178	;	;	PUNCT
admet-916	1	179	tel	tel	PROPN
admet-916	1	180	.	.	PUNCT
admet-916	1	181	:	:	PUNCT
admet-916	2	1	+387	+387	NUM
admet-916	2	2	-	-	SYM
admet-916	2	3	33	33	NUM
admet-916	2	4	-	-	PUNCT
admet-916	2	5	586	586	NUM
admet-916	2	6	-	-	SYM
admet-916	2	7	173	173	NUM
admet-916	2	8	;	;	PUNCT
admet-916	2	9	fax	fax	NOUN
admet-916	2	10	:	:	PUNCT
admet-916	2	11	+387	+387	ADJ
admet-916	2	12	-	-	PUNCT
admet-916	2	13	33	33	NUM
admet-916	2	14	-	-	PUNCT
admet-916	2	15	586	586	NUM
admet-916	2	16	-	-	SYM
admet-916	2	17	180	180	NUM
admet-916	2	18	received	receive	VERB
admet-916	2	19	:	:	PUNCT
admet-916	2	20	october	october	PROPN
admet-916	2	21	16	16	NUM
admet-916	2	22	,	,	PUNCT
admet-916	2	23	2020	2020	NUM
admet-916	2	24	;	;	PUNCT
admet-916	2	25	revised	revise	VERB
admet-916	2	26	:	:	PUNCT
admet-916	2	27	december	december	PROPN
admet-916	2	28	02	02	NUM
admet-916	2	29	,	,	PUNCT
admet-916	2	30	2020	2020	NUM
admet-916	2	31	;	;	PUNCT
admet-916	2	32	published	publish	VERB
admet-916	2	33	:	:	PUNCT
admet-916	2	34	december	december	PROPN
admet-916	2	35	09	09	NUM
admet-916	2	36	,	,	PUNCT
admet-916	2	37	2020	2020	NUM
admet-916	2	38	abstract	abstract	VERB
admet-916	2	39	the	the	DET
admet-916	2	40	kinetics	kinetic	NOUN
admet-916	2	41	of	of	ADP
admet-916	2	42	passive	passive	ADJ
admet-916	2	43	transport	transport	NOUN
admet-916	2	44	of	of	ADP
admet-916	2	45	ketoprofen	ketoprofen	NOUN
admet-916	2	46	and	and	CCONJ
admet-916	2	47	metformin	metformin	NOUN
admet-916	2	48	,	,	PUNCT
admet-916	2	49	as	as	ADP
admet-916	2	50	model	model	NOUN
admet-916	2	51	substances	substance	NOUN
admet-916	2	52	for	for	ADP
admet-916	2	53	high	high	ADJ
admet-916	2	54	and	and	CCONJ
admet-916	2	55	low	low	ADJ
admet-916	2	56	permeability	permeability	NOUN
admet-916	2	57	,	,	PUNCT
admet-916	2	58	respectively	respectively	ADV
admet-916	2	59	,	,	PUNCT
admet-916	2	60	across	across	ADP
admet-916	2	61	the	the	DET
admet-916	2	62	artificial	artificial	ADJ
admet-916	2	63	membrane	membrane	NOUN
admet-916	2	64	under	under	ADP
admet-916	2	65	the	the	DET
admet-916	2	66	influence	influence	NOUN
admet-916	2	67	of	of	ADP
admet-916	2	68	the	the	DET
admet-916	2	69	ph	ph	NOUN
admet-916	2	70	of	of	ADP
admet-916	2	71	donor	donor	NOUN
admet-916	2	72	solution	solution	NOUN
admet-916	2	73	was	be	AUX
admet-916	2	74	investigated	investigate	VERB
admet-916	2	75	.	.	PUNCT
admet-916	3	1	there	there	PRON
admet-916	3	2	was	be	VERB
admet-916	3	3	an	an	DET
admet-916	3	4	upward	upward	ADJ
admet-916	3	5	trend	trend	NOUN
admet-916	3	6	in	in	ADP
admet-916	3	7	the	the	DET
admet-916	3	8	apparent	apparent	ADJ
admet-916	3	9	permeation	permeation	NOUN
admet-916	3	10	coefficient	coefficient	NOUN
admet-916	3	11	(	(	PUNCT
admet-916	3	12	papp	papp	NOUN
admet-916	3	13	)	)	PUNCT
admet-916	3	14	of	of	ADP
admet-916	3	15	ketoprofen	ketoprofen	VERB
admet-916	3	16	with	with	ADP
admet-916	3	17	the	the	DET
admet-916	3	18	decrease	decrease	NOUN
admet-916	3	19	in	in	ADP
admet-916	3	20	ph	ph	NOUN
admet-916	3	21	to	to	ADP
admet-916	3	22	a	a	DET
admet-916	3	23	value	value	NOUN
admet-916	3	24	close	close	ADV
admet-916	3	25	to	to	ADP
admet-916	3	26	pka	pka	PROPN
admet-916	3	27	.	.	PUNCT
admet-916	4	1	at	at	ADP
admet-916	4	2	the	the	DET
admet-916	4	3	ph	ph	ADJ
admet-916	4	4	value	value	NOUN
admet-916	4	5	below	below	ADP
admet-916	4	6	pka	pka	PROPN
admet-916	4	7	the	the	DET
admet-916	4	8	permeation	permeation	NOUN
admet-916	4	9	coefficient	coefficient	NOUN
admet-916	4	10	had	have	VERB
admet-916	4	11	lower	low	ADJ
admet-916	4	12	value	value	NOUN
admet-916	4	13	,	,	PUNCT
admet-916	4	14	due	due	ADP
admet-916	4	15	to	to	ADP
admet-916	4	16	the	the	DET
admet-916	4	17	higher	high	ADJ
admet-916	4	18	retention	retention	NOUN
admet-916	4	19	of	of	ADP
admet-916	4	20	ketoprofen	ketoprofen	NOUN
admet-916	4	21	in	in	ADP
admet-916	4	22	the	the	DET
admet-916	4	23	artificial	artificial	ADJ
admet-916	4	24	membrane	membrane	NOUN
admet-916	4	25	.	.	PUNCT
admet-916	5	1	metformin	metformin	NOUN
admet-916	5	2	is	be	AUX
admet-916	5	3	a	a	DET
admet-916	5	4	low	low	ADJ
admet-916	5	5	permeable	permeable	ADJ
admet-916	5	6	compound	compound	NOUN
admet-916	5	7	,	,	PUNCT
admet-916	5	8	and	and	CCONJ
admet-916	5	9	the	the	DET
admet-916	5	10	highest	high	ADJ
admet-916	5	11	permeation	permeation	NOUN
admet-916	5	12	values	value	NOUN
admet-916	5	13	were	be	AUX
admet-916	5	14	recorded	record	VERB
admet-916	5	15	at	at	ADP
admet-916	5	16	ph	ph	PROPN
admet-916	5	17	7.4	7.4	NUM
admet-916	5	18	.	.	PUNCT
admet-916	6	1	two	two	NUM
admet-916	6	2	dissociation	dissociation	NOUN
admet-916	6	3	constants	constant	NOUN
admet-916	6	4	determine	determine	VERB
admet-916	6	5	that	that	SCONJ
admet-916	6	6	metformin	metformin	NOUN
admet-916	6	7	at	at	ADP
admet-916	6	8	physiological	physiological	ADJ
admet-916	6	9	ph	ph	NOUN
admet-916	6	10	exists	exist	NOUN
admet-916	6	11	as	as	ADP
admet-916	6	12	a	a	DET
admet-916	6	13	hydrophilic	hydrophilic	ADJ
admet-916	6	14	cationic	cationic	ADJ
admet-916	6	15	molecule	molecule	NOUN
admet-916	6	16	,	,	PUNCT
admet-916	6	17	i.e.	i.e.	X
admet-916	6	18	predominantly	predominantly	ADV
admet-916	6	19	in	in	ADP
admet-916	6	20	ionized	ionized	ADJ
admet-916	6	21	form	form	NOUN
admet-916	6	22	.	.	PUNCT
admet-916	7	1	at	at	ADP
admet-916	7	2	ph	ph	ADJ
admet-916	7	3	values	value	NOUN
admet-916	7	4	below	below	ADP
admet-916	7	5	2.8	2.8	NUM
admet-916	7	6	,	,	PUNCT
admet-916	7	7	metformin	metformin	NOUN
admet-916	7	8	mainly	mainly	ADV
admet-916	7	9	exists	exist	VERB
admet-916	7	10	in	in	ADP
admet-916	7	11	diprotonated	diprotonate	VERB
admet-916	7	12	form	form	NOUN
admet-916	7	13	,	,	PUNCT
admet-916	7	14	and	and	CCONJ
admet-916	7	15	it	it	PRON
admet-916	7	16	was	be	AUX
admet-916	7	17	,	,	PUNCT
admet-916	7	18	thus	thus	ADV
admet-916	7	19	,	,	PUNCT
admet-916	7	20	very	very	ADV
admet-916	7	21	poorly	poorly	ADV
admet-916	7	22	permeable	permeable	ADJ
admet-916	7	23	.	.	PUNCT
admet-916	8	1	the	the	DET
admet-916	8	2	highest	high	ADJ
admet-916	8	3	retention	retention	NOUN
admet-916	8	4	,	,	PUNCT
admet-916	8	5	i.e.	i.e.	X
admet-916	8	6	affinity	affinity	NOUN
admet-916	8	7	of	of	ADP
admet-916	8	8	both	both	DET
admet-916	8	9	ketoprofen	ketoprofen	VERB
admet-916	8	10	and	and	CCONJ
admet-916	8	11	metformin	metformin	NOUN
admet-916	8	12	to	to	ADP
admet-916	8	13	the	the	DET
admet-916	8	14	membrane	membrane	NOUN
admet-916	8	15	,	,	PUNCT
admet-916	8	16	was	be	AUX
admet-916	8	17	at	at	ADP
admet-916	8	18	the	the	DET
admet-916	8	19	lowest	low	ADJ
admet-916	8	20	ph	ph	ADJ
admet-916	8	21	values	value	NOUN
admet-916	8	22	,	,	PUNCT
admet-916	8	23	which	which	PRON
admet-916	8	24	is	be	AUX
admet-916	8	25	explained	explain	VERB
admet-916	8	26	by	by	ADP
admet-916	8	27	different	different	ADJ
admet-916	8	28	mechanisms	mechanism	NOUN
admet-916	8	29	.	.	PUNCT
admet-916	9	1	at	at	ADP
admet-916	9	2	higher	high	ADJ
admet-916	9	3	ph	ph	ADJ
admet-916	9	4	values	value	NOUN
admet-916	9	5	of	of	ADP
admet-916	9	6	donor	donor	NOUN
admet-916	9	7	compartment	compartment	VERB
admet-916	9	8	the	the	DET
admet-916	9	9	substances	substance	NOUN
admet-916	9	10	showed	show	VERB
admet-916	9	11	significantly	significantly	ADV
admet-916	9	12	less	less	ADJ
admet-916	9	13	affinity	affinity	NOUN
admet-916	9	14	to	to	ADP
admet-916	9	15	the	the	DET
admet-916	9	16	membrane	membrane	NOUN
admet-916	9	17	.	.	PUNCT
admet-916	10	1	the	the	DET
admet-916	10	2	obtained	obtain	VERB
admet-916	10	3	values	value	NOUN
admet-916	10	4	of	of	ADP
admet-916	10	5	apparent	apparent	ADJ
admet-916	10	6	permeation	permeation	NOUN
admet-916	10	7	coefficients	coefficient	NOUN
admet-916	10	8	at	at	ADP
admet-916	10	9	studied	studied	ADJ
admet-916	10	10	ph	ph	ADJ
admet-916	10	11	values	value	NOUN
admet-916	10	12	showed	show	VERB
admet-916	10	13	good	good	ADJ
admet-916	10	14	correlation	correlation	NOUN
admet-916	10	15	with	with	ADP
admet-916	10	16	the	the	DET
admet-916	10	17	obtained	obtain	VERB
admet-916	10	18	experimental	experimental	ADJ
admet-916	10	19	values	value	NOUN
admet-916	10	20	by	by	ADP
admet-916	10	21	other	other	ADJ
admet-916	10	22	in	in	ADP
admet-916	10	23	vitro	vitro	X
admet-916	10	24	methods	method	NOUN
admet-916	10	25	.	.	PUNCT
admet-916	11	1	©	©	NOUN
admet-916	11	2	2021	2021	NUM
admet-916	11	3	by	by	ADP
admet-916	11	4	the	the	DET
admet-916	11	5	authors	author	NOUN
admet-916	11	6	.	.	PUNCT
admet-916	12	1	this	this	DET
admet-916	12	2	article	article	NOUN
admet-916	12	3	is	be	AUX
admet-916	12	4	an	an	DET
admet-916	12	5	open	open	ADJ
admet-916	12	6	-	-	PUNCT
admet-916	12	7	access	access	NOUN
admet-916	12	8	article	article	NOUN
admet-916	12	9	distributed	distribute	VERB
admet-916	12	10	under	under	ADP
admet-916	12	11	the	the	DET
admet-916	12	12	terms	term	NOUN
admet-916	12	13	and	and	CCONJ
admet-916	12	14	conditions	condition	NOUN
admet-916	12	15	of	of	ADP
admet-916	12	16	the	the	DET
admet-916	12	17	creative	creative	ADJ
admet-916	12	18	commons	common	NOUN
admet-916	12	19	attribution	attribution	NOUN
admet-916	12	20	license	license	NOUN
admet-916	12	21	(	(	PUNCT
admet-916	12	22	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-916	12	23	)	)	PUNCT
admet-916	12	24	.	.	PUNCT
admet-916	13	1	keywords	keyword	VERB
admet-916	13	2	dynamic	dynamic	ADJ
admet-916	13	3	diffusion	diffusion	NOUN
admet-916	13	4	cell	cell	NOUN
admet-916	13	5	model	model	NOUN
admet-916	13	6	;	;	PUNCT
admet-916	13	7	artificial	artificial	ADJ
admet-916	13	8	membrane	membrane	NOUN
admet-916	13	9	;	;	PUNCT
admet-916	13	10	in	in	ADP
admet-916	13	11	vitro	vitro	X
admet-916	13	12	permeation	permeation	NOUN
admet-916	13	13	;	;	PUNCT
admet-916	13	14	bcs	bcs	PROPN
admet-916	13	15	ii	ii	PROPN
admet-916	13	16	;	;	PUNCT
admet-916	13	17	bcs	bcs	NOUN
admet-916	13	18	iii	iii	NUM
admet-916	13	19	introduction	introduction	NOUN
admet-916	13	20	the	the	DET
admet-916	13	21	oral	oral	ADJ
admet-916	13	22	route	route	NOUN
admet-916	13	23	is	be	AUX
admet-916	13	24	the	the	DET
admet-916	13	25	most	most	ADV
admet-916	13	26	preferred	preferred	ADJ
admet-916	13	27	route	route	NOUN
admet-916	13	28	of	of	ADP
admet-916	13	29	drug	drug	NOUN
admet-916	13	30	administration	administration	NOUN
admet-916	13	31	.	.	PUNCT
admet-916	14	1	it	it	PRON
admet-916	14	2	is	be	AUX
admet-916	14	3	considered	consider	VERB
admet-916	14	4	safe	safe	ADJ
admet-916	14	5	,	,	PUNCT
admet-916	14	6	effective	effective	ADJ
admet-916	14	7	,	,	PUNCT
admet-916	14	8	and	and	CCONJ
admet-916	14	9	readily	readily	ADV
admet-916	14	10	available	available	ADJ
admet-916	14	11	,	,	PUNCT
admet-916	14	12	with	with	ADP
admet-916	14	13	minimal	minimal	ADJ
admet-916	14	14	discomfort	discomfort	NOUN
admet-916	14	15	to	to	ADP
admet-916	14	16	the	the	DET
admet-916	14	17	patient	patient	NOUN
admet-916	14	18	compared	compare	VERB
admet-916	14	19	to	to	ADP
admet-916	14	20	other	other	ADJ
admet-916	14	21	routes	route	NOUN
admet-916	14	22	[	[	X
admet-916	14	23	1	1	NUM
admet-916	14	24	]	]	PUNCT
admet-916	14	25	.	.	PUNCT
admet-916	15	1	the	the	DET
admet-916	15	2	absorption	absorption	NOUN
admet-916	15	3	of	of	ADP
admet-916	15	4	orally	orally	ADV
admet-916	15	5	administered	administer	VERB
admet-916	15	6	drugs	drug	NOUN
admet-916	15	7	is	be	AUX
admet-916	15	8	a	a	DET
admet-916	15	9	function	function	NOUN
admet-916	15	10	of	of	ADP
admet-916	15	11	its	its	PRON
admet-916	15	12	dissolution	dissolution	NOUN
admet-916	15	13	,	,	PUNCT
admet-916	15	14	solubility	solubility	NOUN
admet-916	15	15	and	and	CCONJ
admet-916	15	16	permeability	permeability	NOUN
admet-916	15	17	of	of	ADP
admet-916	15	18	the	the	DET
admet-916	15	19	substance	substance	NOUN
admet-916	15	20	along	along	ADP
admet-916	15	21	the	the	DET
admet-916	15	22	length	length	NOUN
admet-916	15	23	of	of	ADP
admet-916	15	24	the	the	DET
admet-916	15	25	gastrointestinal	gastrointestinal	ADJ
admet-916	15	26	tract	tract	NOUN
admet-916	15	27	(	(	PUNCT
admet-916	15	28	git	git	NOUN
admet-916	15	29	)	)	PUNCT
admet-916	16	1	[	[	X
admet-916	16	2	2	2	NUM
admet-916	16	3	]	]	PUNCT
admet-916	16	4	.	.	PUNCT
admet-916	17	1	the	the	DET
admet-916	17	2	absorption	absorption	NOUN
admet-916	17	3	of	of	ADP
admet-916	17	4	active	active	ADJ
admet-916	17	5	substances	substance	NOUN
admet-916	17	6	varies	vary	VERB
admet-916	17	7	depending	depend	VERB
admet-916	17	8	on	on	ADP
admet-916	17	9	the	the	DET
admet-916	17	10	ph	ph	NOUN
admet-916	17	11	along	along	ADP
admet-916	17	12	the	the	DET
admet-916	17	13	gastrointestinal	gastrointestinal	ADJ
admet-916	17	14	tract	tract	NOUN
admet-916	17	15	[	[	X
admet-916	17	16	3	3	NUM
admet-916	17	17	]	]	PUNCT
admet-916	17	18	.	.	PUNCT
admet-916	18	1	in	in	ADP
admet-916	18	2	general	general	ADJ
admet-916	18	3	,	,	PUNCT
admet-916	18	4	the	the	DET
admet-916	18	5	absorption	absorption	NOUN
admet-916	18	6	of	of	ADP
admet-916	18	7	active	active	ADJ
admet-916	18	8	substances	substance	NOUN
admet-916	18	9	mainly	mainly	ADV
admet-916	18	10	takes	take	VERB
admet-916	18	11	place	place	NOUN
admet-916	18	12	in	in	ADP
admet-916	18	13	the	the	DET
admet-916	18	14	small	small	ADJ
admet-916	18	15	intestine	intestine	NOUN
admet-916	18	16	,	,	PUNCT
admet-916	18	17	i.e.	i.e.	X
admet-916	18	18	in	in	ADP
admet-916	18	19	the	the	DET
admet-916	18	20	jejunum	jejunum	NOUN
admet-916	18	21	which	which	PRON
admet-916	18	22	has	have	VERB
admet-916	18	23	the	the	DET
admet-916	18	24	largest	large	ADJ
admet-916	18	25	absorption	absorption	NOUN
admet-916	18	26	surface	surface	NOUN
admet-916	19	1	[	[	X
admet-916	19	2	4	4	NUM
admet-916	19	3	]	]	PUNCT
admet-916	19	4	.	.	PUNCT
admet-916	20	1	http://dx.doi.org/10.5599/admet.916	http://dx.doi.org/10.5599/admet.916	PROPN
admet-916	20	2	https://doi.org/10.5599/admet.916	https://doi.org/10.5599/admet.916	PROPN
admet-916	20	3	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	PROPN
admet-916	20	4	mailto:alisa.elezovic@ffsa.unsa.ba	mailto:alisa.elezovic@ffsa.unsa.ba	PROPN
admet-916	20	5	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-916	20	6	alisa	alisa	PROPN
admet-916	20	7	elezović	elezović	PROPN
admet-916	20	8	et	et	PROPN
admet-916	20	9	al	al	PROPN
admet-916	20	10	.	.	PROPN
admet-916	20	11	admet	admet	PROPN
admet-916	20	12	&	&	CCONJ
admet-916	20	13	dmpk	dmpk	PROPN
admet-916	20	14	9(1	9(1	NUM
admet-916	20	15	)	)	PUNCT
admet-916	20	16	(	(	PUNCT
admet-916	20	17	2021	2021	NUM
admet-916	20	18	)	)	PUNCT
admet-916	20	19	57	57	NUM
admet-916	20	20	-	-	SYM
admet-916	20	21	68	68	NUM
admet-916	20	22	58	58	NUM
admet-916	20	23	the	the	DET
admet-916	20	24	biopharmaceutical	biopharmaceutical	ADJ
admet-916	20	25	classification	classification	NOUN
admet-916	20	26	system	system	NOUN
admet-916	20	27	(	(	PUNCT
admet-916	20	28	bcs	bcs	NOUN
admet-916	20	29	)	)	PUNCT
admet-916	20	30	categorizes	categorize	VERB
admet-916	20	31	drugs	drug	NOUN
admet-916	20	32	into	into	ADP
admet-916	20	33	four	four	NUM
admet-916	20	34	classes	class	NOUN
admet-916	20	35	according	accord	VERB
admet-916	20	36	to	to	ADP
admet-916	20	37	their	their	PRON
admet-916	20	38	water	water	NOUN
admet-916	20	39	solubility	solubility	NOUN
admet-916	20	40	and	and	CCONJ
admet-916	20	41	permeability	permeability	NOUN
admet-916	20	42	across	across	ADP
admet-916	20	43	intestinal	intestinal	ADJ
admet-916	20	44	membrane	membrane	NOUN
admet-916	20	45	.	.	PUNCT
admet-916	21	1	based	base	VERB
admet-916	21	2	on	on	ADP
admet-916	21	3	the	the	DET
admet-916	21	4	available	available	ADJ
admet-916	21	5	data	datum	NOUN
admet-916	21	6	on	on	ADP
admet-916	21	7	low	low	ADJ
admet-916	21	8	solubility	solubility	NOUN
admet-916	21	9	and	and	CCONJ
admet-916	21	10	high	high	ADJ
admet-916	21	11	permeability	permeability	NOUN
admet-916	21	12	of	of	ADP
admet-916	21	13	ketoprofen	ketoprofen	NOUN
admet-916	21	14	,	,	PUNCT
admet-916	21	15	it	it	PRON
admet-916	21	16	belongs	belong	VERB
admet-916	21	17	to	to	ADP
admet-916	21	18	class	class	PROPN
admet-916	21	19	ii	ii	PROPN
admet-916	21	20	(	(	PUNCT
admet-916	21	21	bcs	bcs	PROPN
admet-916	21	22	ii	ii	PROPN
admet-916	21	23	)	)	PUNCT
admet-916	22	1	[	[	X
admet-916	22	2	5	5	NUM
admet-916	22	3	]	]	PUNCT
admet-916	22	4	,	,	PUNCT
admet-916	22	5	while	while	SCONJ
admet-916	22	6	metformin	metformin	NOUN
admet-916	22	7	as	as	ADP
admet-916	22	8	a	a	DET
admet-916	22	9	highly	highly	ADV
admet-916	22	10	soluble	soluble	ADJ
admet-916	22	11	and	and	CCONJ
admet-916	22	12	low	low	ADJ
admet-916	22	13	permeable	permeable	ADJ
admet-916	22	14	substance	substance	NOUN
admet-916	22	15	belongs	belong	VERB
admet-916	22	16	to	to	ADP
admet-916	22	17	bsc	bsc	PROPN
admet-916	22	18	class	class	PROPN
admet-916	22	19	iii	iii	PROPN
admet-916	23	1	[	[	X
admet-916	23	2	6	6	NUM
admet-916	23	3	]	]	PUNCT
admet-916	23	4	.	.	PUNCT
admet-916	24	1	ketoprofen	ketoprofen	PROPN
admet-916	24	2	is	be	AUX
admet-916	24	3	a	a	DET
admet-916	24	4	non	non	ADJ
admet-916	24	5	-	-	ADJ
admet-916	24	6	steroidal	steroidal	ADJ
admet-916	24	7	anti	anti	ADJ
admet-916	24	8	-	-	ADJ
admet-916	24	9	inflammatory	inflammatory	ADJ
admet-916	24	10	analgesic	analgesic	NOUN
admet-916	24	11	.	.	PUNCT
admet-916	25	1	within	within	ADP
admet-916	25	2	the	the	DET
admet-916	25	3	ph	ph	NOUN
admet-916	25	4	of	of	ADP
admet-916	25	5	the	the	DET
admet-916	25	6	gastrointestinal	gastrointestinal	ADJ
admet-916	25	7	tract	tract	NOUN
admet-916	25	8	,	,	PUNCT
admet-916	25	9	ketoprofen	ketoprofen	PROPN
admet-916	25	10	is	be	AUX
admet-916	25	11	an	an	DET
admet-916	25	12	ionized	ionized	ADJ
admet-916	25	13	substance	substance	NOUN
admet-916	25	14	(	(	PUNCT
admet-916	25	15	weak	weak	ADJ
admet-916	25	16	acid	acid	NOUN
admet-916	25	17	)	)	PUNCT
admet-916	25	18	.	.	PUNCT
admet-916	26	1	the	the	DET
admet-916	26	2	pka	pka	PROPN
admet-916	26	3	value	value	NOUN
admet-916	26	4	of	of	ADP
admet-916	26	5	ketoprofen	ketoprofen	NOUN
admet-916	26	6	is	be	AUX
admet-916	26	7	approximately	approximately	ADV
admet-916	26	8	4.45	4.45	NUM
admet-916	26	9	at	at	ADP
admet-916	26	10	25	25	NUM
admet-916	26	11	°	°	NOUN
admet-916	26	12	c	c	NOUN
admet-916	26	13	[	[	X
admet-916	26	14	7	7	NUM
admet-916	26	15	]	]	PUNCT
admet-916	26	16	.	.	PUNCT
admet-916	27	1	metformin	metformin	NOUN
admet-916	27	2	is	be	AUX
admet-916	27	3	often	often	ADV
admet-916	27	4	described	describe	VERB
admet-916	27	5	as	as	ADP
admet-916	27	6	an	an	DET
admet-916	27	7	insulin	insulin	NOUN
admet-916	27	8	stabilizer	stabilizer	NOUN
admet-916	27	9	because	because	SCONJ
admet-916	27	10	,	,	PUNCT
admet-916	27	11	due	due	ADP
admet-916	27	12	to	to	ADP
admet-916	27	13	its	its	PRON
admet-916	27	14	positive	positive	ADJ
admet-916	27	15	effects	effect	NOUN
admet-916	27	16	on	on	ADP
admet-916	27	17	insulin	insulin	NOUN
admet-916	27	18	acceptor	acceptor	NOUN
admet-916	27	19	and	and	CCONJ
admet-916	27	20	tyrosine	tyrosine	PROPN
admet-916	27	21	kinase	kinase	PROPN
admet-916	27	22	activity	activity	NOUN
admet-916	27	23	,	,	PUNCT
admet-916	27	24	it	it	PRON
admet-916	27	25	leads	lead	VERB
admet-916	27	26	to	to	ADP
admet-916	27	27	a	a	DET
admet-916	27	28	decrease	decrease	NOUN
admet-916	27	29	in	in	ADP
admet-916	27	30	plasma	plasma	NOUN
admet-916	27	31	insulin	insulin	NOUN
admet-916	27	32	levels	level	NOUN
admet-916	27	33	and	and	CCONJ
admet-916	27	34	insulin	insulin	NOUN
admet-916	27	35	resistance	resistance	NOUN
admet-916	28	1	[	[	X
admet-916	28	2	8	8	NUM
admet-916	28	3	]	]	PUNCT
admet-916	28	4	.	.	PUNCT
admet-916	29	1	metformin	metformin	NOUN
admet-916	29	2	has	have	VERB
admet-916	29	3	two	two	NUM
admet-916	29	4	different	different	ADJ
admet-916	29	5	values	value	NOUN
admet-916	29	6	of	of	ADP
admet-916	29	7	the	the	DET
admet-916	29	8	dissociation	dissociation	NOUN
admet-916	29	9	constant	constant	ADJ
admet-916	29	10	,	,	PUNCT
admet-916	29	11	namely	namely	ADV
admet-916	29	12	pka	pka	PROPN
admet-916	29	13	2.8	2.8	NUM
admet-916	29	14	and	and	CCONJ
admet-916	29	15	11.5	11.5	NUM
admet-916	29	16	,	,	PUNCT
admet-916	29	17	and	and	CCONJ
admet-916	29	18	as	as	ADP
admet-916	29	19	a	a	DET
admet-916	29	20	result	result	NOUN
admet-916	29	21	of	of	ADP
admet-916	29	22	which	which	PRON
admet-916	29	23	at	at	ADP
admet-916	29	24	physiological	physiological	ADJ
admet-916	29	25	ph	ph	NOUN
admet-916	29	26	it	it	PRON
admet-916	29	27	exists	exist	VERB
admet-916	29	28	as	as	ADP
admet-916	29	29	a	a	DET
admet-916	29	30	hydrophilic	hydrophilic	ADJ
admet-916	29	31	cationic	cationic	ADJ
admet-916	29	32	molecule	molecule	NOUN
admet-916	29	33	.	.	PUNCT
admet-916	30	1	at	at	ADP
admet-916	30	2	ph	ph	ADJ
admet-916	30	3	values	value	NOUN
admet-916	30	4	below	below	ADP
admet-916	30	5	2.8	2.8	NUM
admet-916	30	6	,	,	PUNCT
admet-916	30	7	it	it	PRON
admet-916	30	8	mainly	mainly	ADV
admet-916	30	9	exists	exist	VERB
admet-916	30	10	in	in	ADP
admet-916	30	11	diprotonated	diprotonate	VERB
admet-916	30	12	form	form	NOUN
admet-916	30	13	,	,	PUNCT
admet-916	30	14	and	and	CCONJ
admet-916	30	15	thus	thus	ADV
admet-916	30	16	difficult	difficult	ADJ
admet-916	30	17	to	to	PART
admet-916	30	18	permeate	permeate	VERB
admet-916	30	19	.	.	PUNCT
admet-916	31	1	at	at	ADP
admet-916	31	2	ph	ph	ADJ
admet-916	31	3	values	value	NOUN
admet-916	31	4	higher	high	ADJ
admet-916	31	5	than	than	ADP
admet-916	31	6	11.5	11.5	NUM
admet-916	31	7	it	it	PRON
admet-916	31	8	is	be	AUX
admet-916	31	9	found	find	VERB
admet-916	31	10	in	in	ADP
admet-916	31	11	non	non	ADJ
admet-916	31	12	-	-	ADJ
admet-916	31	13	ionized	ionized	ADJ
admet-916	31	14	form	form	NOUN
admet-916	31	15	which	which	PRON
admet-916	31	16	is	be	AUX
admet-916	31	17	the	the	DET
admet-916	31	18	most	most	ADV
admet-916	31	19	favorable	favorable	ADJ
admet-916	31	20	form	form	NOUN
admet-916	31	21	for	for	ADP
admet-916	31	22	passive	passive	ADJ
admet-916	31	23	transport	transport	NOUN
admet-916	31	24	across	across	ADP
admet-916	31	25	membranes	membrane	NOUN
admet-916	31	26	[	[	X
admet-916	31	27	9	9	NUM
admet-916	31	28	]	]	PUNCT
admet-916	31	29	,	,	PUNCT
admet-916	31	30	however	however	ADV
admet-916	31	31	this	this	DET
admet-916	31	32	ph	ph	NOUN
admet-916	31	33	is	be	AUX
admet-916	31	34	not	not	PART
admet-916	31	35	found	find	VERB
admet-916	31	36	physiologically	physiologically	ADV
admet-916	31	37	.	.	PUNCT
admet-916	32	1	models	model	NOUN
admet-916	32	2	for	for	ADP
admet-916	32	3	determining	determine	VERB
admet-916	32	4	permeability	permeability	NOUN
admet-916	32	5	are	be	AUX
admet-916	32	6	used	use	VERB
admet-916	32	7	in	in	ADP
admet-916	32	8	the	the	DET
admet-916	32	9	early	early	ADJ
admet-916	32	10	stages	stage	NOUN
admet-916	32	11	of	of	ADP
admet-916	32	12	drug	drug	NOUN
admet-916	32	13	discovery	discovery	NOUN
admet-916	32	14	and	and	CCONJ
admet-916	32	15	development	development	NOUN
admet-916	32	16	and	and	CCONJ
admet-916	32	17	are	be	AUX
admet-916	32	18	a	a	DET
admet-916	32	19	major	major	ADJ
admet-916	32	20	strategy	strategy	NOUN
admet-916	32	21	to	to	PART
admet-916	32	22	prevent	prevent	VERB
admet-916	32	23	drug	drug	NOUN
admet-916	32	24	rejections	rejection	NOUN
admet-916	32	25	due	due	ADP
admet-916	32	26	to	to	ADP
admet-916	32	27	poor	poor	ADJ
admet-916	32	28	pharmacokinetics	pharmacokinetic	NOUN
admet-916	32	29	in	in	ADP
admet-916	32	30	the	the	DET
admet-916	32	31	later	later	ADJ
admet-916	32	32	,	,	PUNCT
admet-916	32	33	more	more	ADV
admet-916	32	34	expensive	expensive	ADJ
admet-916	32	35	phases	phase	NOUN
admet-916	32	36	of	of	ADP
admet-916	32	37	clinical	clinical	ADJ
admet-916	32	38	trials	trial	NOUN
admet-916	32	39	[	[	X
admet-916	32	40	10	10	NUM
admet-916	32	41	]	]	PUNCT
admet-916	32	42	.	.	PUNCT
admet-916	33	1	the	the	DET
admet-916	33	2	most	most	ADV
admet-916	33	3	reliable	reliable	ADJ
admet-916	33	4	way	way	NOUN
admet-916	33	5	to	to	PART
admet-916	33	6	determine	determine	VERB
admet-916	33	7	the	the	DET
admet-916	33	8	permeation	permeation	NOUN
admet-916	33	9	of	of	ADP
admet-916	33	10	active	active	ADJ
admet-916	33	11	substances	substance	NOUN
admet-916	33	12	is	be	AUX
admet-916	33	13	in	in	ADP
admet-916	33	14	vivo	vivo	ADJ
admet-916	33	15	testing	testing	NOUN
admet-916	33	16	of	of	ADP
admet-916	33	17	human	human	ADJ
admet-916	33	18	intestinal	intestinal	ADJ
admet-916	33	19	perfusion	perfusion	NOUN
admet-916	33	20	.	.	PUNCT
admet-916	34	1	however	however	ADV
admet-916	34	2	,	,	PUNCT
admet-916	34	3	due	due	ADP
admet-916	34	4	to	to	ADP
admet-916	34	5	simpler	simple	ADJ
admet-916	34	6	,	,	PUNCT
admet-916	34	7	faster	fast	ADJ
admet-916	34	8	and	and	CCONJ
admet-916	34	9	much	much	ADV
admet-916	34	10	less	less	ADV
admet-916	34	11	expensive	expensive	ADJ
admet-916	34	12	performance	performance	NOUN
admet-916	34	13	compared	compare	VERB
admet-916	34	14	to	to	ADP
admet-916	34	15	the	the	DET
admet-916	34	16	in	in	ADP
admet-916	34	17	vivo	vivo	NOUN
admet-916	34	18	tests	test	NOUN
admet-916	34	19	,	,	PUNCT
admet-916	34	20	in	in	ADP
admet-916	34	21	situ	situ	NOUN
admet-916	34	22	,	,	PUNCT
admet-916	34	23	ex	ex	NOUN
admet-916	34	24	vivo	vivo	NOUN
admet-916	34	25	and	and	CCONJ
admet-916	34	26	in	in	ADP
admet-916	34	27	vitro	vitro	X
admet-916	34	28	models	model	NOUN
admet-916	34	29	are	be	AUX
admet-916	34	30	mainly	mainly	ADV
admet-916	34	31	used	use	VERB
admet-916	34	32	for	for	ADP
admet-916	34	33	permeation	permeation	NOUN
admet-916	34	34	assessment	assessment	NOUN
admet-916	34	35	[	[	X
admet-916	34	36	11	11	NUM
admet-916	34	37	]	]	PUNCT
admet-916	34	38	.	.	PUNCT
admet-916	35	1	in	in	ADP
admet-916	35	2	vitro	vitro	X
admet-916	35	3	methods	method	NOUN
admet-916	35	4	are	be	AUX
admet-916	35	5	the	the	DET
admet-916	35	6	most	most	ADV
admet-916	35	7	commonly	commonly	ADV
admet-916	35	8	used	use	VERB
admet-916	35	9	alternative	alternative	NOUN
admet-916	35	10	for	for	ADP
admet-916	35	11	testing	test	VERB
admet-916	35	12	the	the	DET
admet-916	35	13	permeation	permeation	NOUN
admet-916	35	14	of	of	ADP
admet-916	35	15	active	active	ADJ
admet-916	35	16	substances	substance	NOUN
admet-916	35	17	[	[	X
admet-916	35	18	12	12	NUM
admet-916	35	19	]	]	PUNCT
admet-916	35	20	.	.	PUNCT
admet-916	36	1	depending	depend	VERB
admet-916	36	2	on	on	ADP
admet-916	36	3	the	the	DET
admet-916	36	4	biopharmaceutical	biopharmaceutical	ADJ
admet-916	36	5	class	class	NOUN
admet-916	36	6	of	of	ADP
admet-916	36	7	the	the	DET
admet-916	36	8	active	active	ADJ
admet-916	36	9	substance	substance	NOUN
admet-916	36	10	,	,	PUNCT
admet-916	36	11	they	they	PRON
admet-916	36	12	may	may	AUX
admet-916	36	13	have	have	VERB
admet-916	36	14	a	a	DET
admet-916	36	15	good	good	ADJ
admet-916	36	16	correlation	correlation	NOUN
admet-916	36	17	with	with	ADP
admet-916	36	18	the	the	DET
admet-916	36	19	in	in	ADJ
admet-916	36	20	vivo	vivo	ADJ
admet-916	36	21	results	result	NOUN
admet-916	36	22	[	[	X
admet-916	36	23	13	13	NUM
admet-916	36	24	]	]	PUNCT
admet-916	36	25	.	.	PUNCT
admet-916	37	1	most	most	ADJ
admet-916	37	2	active	active	ADJ
admet-916	37	3	substances	substance	NOUN
admet-916	37	4	are	be	AUX
admet-916	37	5	absorbed	absorb	VERB
admet-916	37	6	by	by	ADP
admet-916	37	7	passive	passive	ADJ
admet-916	37	8	transport	transport	NOUN
admet-916	37	9	,	,	PUNCT
admet-916	37	10	so	so	SCONJ
admet-916	37	11	the	the	DET
admet-916	37	12	application	application	NOUN
admet-916	37	13	of	of	ADP
admet-916	37	14	in	in	ADP
admet-916	37	15	vitro	vitro	X
admet-916	37	16	methods	method	NOUN
admet-916	37	17	using	use	VERB
admet-916	37	18	artificial	artificial	ADJ
admet-916	37	19	membranes	membrane	NOUN
admet-916	37	20	that	that	PRON
admet-916	37	21	mimic	mimic	VERB
admet-916	37	22	passive	passive	ADJ
admet-916	37	23	transport	transport	NOUN
admet-916	37	24	is	be	AUX
admet-916	37	25	considered	consider	VERB
admet-916	37	26	an	an	DET
admet-916	37	27	effective	effective	ADJ
admet-916	37	28	and	and	CCONJ
admet-916	37	29	reproducible	reproducible	ADJ
admet-916	37	30	method	method	NOUN
admet-916	37	31	for	for	ADP
admet-916	37	32	assessing	assess	VERB
admet-916	37	33	permeability	permeability	NOUN
admet-916	37	34	[	[	X
admet-916	37	35	12	12	NUM
admet-916	37	36	]	]	PUNCT
admet-916	37	37	,	,	PUNCT
admet-916	37	38	especially	especially	ADV
admet-916	37	39	in	in	ADP
admet-916	37	40	screening	screen	VERB
admet-916	37	41	stages	stage	NOUN
admet-916	37	42	of	of	ADP
admet-916	37	43	drug	drug	NOUN
admet-916	37	44	discovery	discovery	NOUN
admet-916	37	45	.	.	PUNCT
admet-916	38	1	absorption	absorption	NOUN
admet-916	38	2	,	,	PUNCT
admet-916	38	3	distribution	distribution	NOUN
admet-916	38	4	,	,	PUNCT
admet-916	38	5	metabolism	metabolism	NOUN
admet-916	38	6	,	,	PUNCT
admet-916	38	7	excretion	excretion	NOUN
admet-916	38	8	and	and	CCONJ
admet-916	38	9	toxicity	toxicity	NOUN
admet-916	38	10	are	be	AUX
admet-916	38	11	greatly	greatly	ADV
admet-916	38	12	influenced	influence	VERB
admet-916	38	13	by	by	ADP
admet-916	38	14	the	the	DET
admet-916	38	15	charge	charge	NOUN
admet-916	38	16	of	of	ADP
admet-916	38	17	the	the	DET
admet-916	38	18	active	active	ADJ
admet-916	38	19	substances	substance	NOUN
admet-916	38	20	at	at	ADP
admet-916	38	21	different	different	ADJ
admet-916	38	22	ph	ph	ADJ
admet-916	38	23	conditions	condition	NOUN
admet-916	38	24	.	.	PUNCT
admet-916	39	1	consideration	consideration	NOUN
admet-916	39	2	of	of	ADP
admet-916	39	3	ph	ph	ADJ
admet-916	39	4	values	value	NOUN
admet-916	39	5	in	in	ADP
admet-916	39	6	relation	relation	NOUN
admet-916	39	7	to	to	ADP
admet-916	39	8	other	other	ADJ
admet-916	39	9	molecular	molecular	ADJ
admet-916	39	10	properties	property	NOUN
admet-916	39	11	is	be	AUX
admet-916	39	12	of	of	ADP
admet-916	39	13	great	great	ADJ
admet-916	39	14	importance	importance	NOUN
admet-916	39	15	and	and	CCONJ
admet-916	39	16	has	have	VERB
admet-916	39	17	the	the	DET
admet-916	39	18	potential	potential	NOUN
admet-916	39	19	to	to	PART
admet-916	39	20	be	be	AUX
admet-916	39	21	used	use	VERB
admet-916	39	22	to	to	PART
admet-916	39	23	further	far	ADV
admet-916	39	24	improve	improve	VERB
admet-916	39	25	the	the	DET
admet-916	39	26	efficacy	efficacy	NOUN
admet-916	39	27	of	of	ADP
admet-916	39	28	the	the	DET
admet-916	39	29	application	application	NOUN
admet-916	39	30	of	of	ADP
admet-916	39	31	active	active	ADJ
admet-916	39	32	substances	substance	NOUN
admet-916	39	33	[	[	X
admet-916	39	34	14	14	NUM
admet-916	39	35	]	]	PUNCT
admet-916	39	36	.	.	PUNCT
admet-916	40	1	the	the	DET
admet-916	40	2	method	method	NOUN
admet-916	40	3	of	of	ADP
admet-916	40	4	permeation	permeation	NOUN
admet-916	40	5	testing	testing	NOUN
admet-916	40	6	on	on	ADP
admet-916	40	7	artificial	artificial	ADJ
admet-916	40	8	membranes	membrane	NOUN
admet-916	40	9	,	,	PUNCT
admet-916	40	10	which	which	PRON
admet-916	40	11	could	could	AUX
admet-916	40	12	reliably	reliably	ADV
admet-916	40	13	predict	predict	VERB
admet-916	40	14	the	the	DET
admet-916	40	15	passive	passive	ADJ
admet-916	40	16	transport	transport	NOUN
admet-916	40	17	of	of	ADP
admet-916	40	18	the	the	DET
admet-916	40	19	active	active	ADJ
admet-916	40	20	substance	substance	NOUN
admet-916	40	21	as	as	ADP
admet-916	40	22	a	a	DET
admet-916	40	23	function	function	NOUN
admet-916	40	24	of	of	ADP
admet-916	40	25	ph	ph	NOUN
admet-916	40	26	,	,	PUNCT
admet-916	40	27	would	would	AUX
admet-916	40	28	significantly	significantly	ADV
admet-916	40	29	facilitate	facilitate	VERB
admet-916	40	30	the	the	DET
admet-916	40	31	characterization	characterization	NOUN
admet-916	40	32	of	of	ADP
admet-916	40	33	new	new	ADJ
admet-916	40	34	candidate	candidate	NOUN
admet-916	40	35	substances	substance	NOUN
admet-916	40	36	in	in	ADP
admet-916	40	37	the	the	DET
admet-916	40	38	initial	initial	ADJ
admet-916	40	39	stages	stage	NOUN
admet-916	40	40	of	of	ADP
admet-916	40	41	drug	drug	NOUN
admet-916	40	42	development	development	NOUN
admet-916	40	43	.	.	PUNCT
admet-916	41	1	in	in	ADP
admet-916	41	2	this	this	DET
admet-916	41	3	work	work	NOUN
admet-916	41	4	,	,	PUNCT
admet-916	41	5	the	the	DET
admet-916	41	6	kinetics	kinetic	NOUN
admet-916	41	7	of	of	ADP
admet-916	41	8	passive	passive	ADJ
admet-916	41	9	transport	transport	NOUN
admet-916	41	10	of	of	ADP
admet-916	41	11	ketoprofen	ketoprofen	NOUN
admet-916	41	12	(	(	PUNCT
admet-916	41	13	bcs	bcs	NOUN
admet-916	41	14	ii	ii	PROPN
admet-916	41	15	)	)	PUNCT
admet-916	41	16	and	and	CCONJ
admet-916	41	17	metformin	metformin	NOUN
admet-916	41	18	(	(	PUNCT
admet-916	41	19	bcs	bcs	NOUN
admet-916	41	20	iii	iii	NUM
admet-916	41	21	)	)	PUNCT
admet-916	41	22	,	,	PUNCT
admet-916	41	23	as	as	ADP
admet-916	41	24	model	model	NOUN
admet-916	41	25	substances	substance	NOUN
admet-916	41	26	for	for	ADP
admet-916	41	27	high	high	ADJ
admet-916	41	28	and	and	CCONJ
admet-916	41	29	low	low	ADJ
admet-916	41	30	permeability	permeability	NOUN
admet-916	41	31	,	,	PUNCT
admet-916	41	32	respectively	respectively	ADV
admet-916	41	33	,	,	PUNCT
admet-916	41	34	across	across	ADP
admet-916	41	35	the	the	DET
admet-916	41	36	artificial	artificial	ADJ
admet-916	41	37	membrane	membrane	NOUN
admet-916	41	38	under	under	ADP
admet-916	41	39	the	the	DET
admet-916	41	40	influence	influence	NOUN
admet-916	41	41	of	of	ADP
admet-916	41	42	the	the	DET
admet-916	41	43	ph	ph	ADJ
admet-916	41	44	value	value	NOUN
admet-916	41	45	of	of	ADP
admet-916	41	46	the	the	DET
admet-916	41	47	donor	donor	NOUN
admet-916	41	48	solution	solution	NOUN
admet-916	41	49	was	be	AUX
admet-916	41	50	investigated	investigate	VERB
admet-916	41	51	.	.	PUNCT
admet-916	42	1	the	the	DET
admet-916	42	2	results	result	NOUN
admet-916	42	3	were	be	AUX
admet-916	42	4	compared	compare	VERB
admet-916	42	5	with	with	ADP
admet-916	42	6	the	the	DET
admet-916	42	7	available	available	ADJ
admet-916	42	8	literature	literature	PROPN
admet-916	42	9	data	datum	NOUN
admet-916	42	10	obtained	obtain	VERB
admet-916	42	11	by	by	ADP
admet-916	42	12	different	different	ADJ
admet-916	42	13	permeation	permeation	NOUN
admet-916	42	14	methods	method	NOUN
admet-916	42	15	of	of	ADP
admet-916	42	16	these	these	DET
admet-916	42	17	two	two	NUM
admet-916	42	18	substances	substance	NOUN
admet-916	42	19	.	.	PUNCT
admet-916	43	1	experimental	experimental	ADJ
admet-916	43	2	materials	material	NOUN
admet-916	43	3	deionized	deionize	VERB
admet-916	43	4	water	water	NOUN
admet-916	43	5	was	be	AUX
admet-916	43	6	obtained	obtain	VERB
admet-916	43	7	on	on	ADP
admet-916	43	8	arium	arium	NOUN
admet-916	43	9	611	611	NUM
admet-916	43	10	,	,	PUNCT
admet-916	43	11	sartorius	sartorius	NOUN
admet-916	43	12	(	(	PUNCT
admet-916	43	13	sartorius	sartorius	NOUN
admet-916	43	14	lab	lab	NOUN
admet-916	43	15	instruments	instrument	NOUN
admet-916	43	16	gmbh	gmbh	PROPN
admet-916	43	17	&	&	CCONJ
admet-916	43	18	co.	co.	PROPN
admet-916	43	19	kg	kg	PROPN
admet-916	43	20	,	,	PUNCT
admet-916	43	21	göttingen	göttingen	NOUN
admet-916	43	22	,	,	PUNCT
admet-916	43	23	germany	germany	PROPN
admet-916	43	24	)	)	PUNCT
admet-916	43	25	.	.	PUNCT
admet-916	44	1	the	the	DET
admet-916	44	2	materials	material	NOUN
admet-916	44	3	used	use	VERB
admet-916	44	4	in	in	ADP
admet-916	44	5	this	this	DET
admet-916	44	6	experimental	experimental	ADJ
admet-916	44	7	work	work	NOUN
admet-916	44	8	include	include	VERB
admet-916	44	9	:	:	PUNCT
admet-916	44	10	disodium	disodium	ADJ
admet-916	44	11	hydrogen	hydrogen	NOUN
admet-916	44	12	phosphate	phosphate	NOUN
admet-916	44	13	admet	admet	PROPN
admet-916	44	14	&	&	CCONJ
admet-916	44	15	dmpk	dmpk	PROPN
admet-916	44	16	9(1	9(1	NUM
admet-916	44	17	)	)	PUNCT
admet-916	44	18	(	(	PUNCT
admet-916	44	19	2021	2021	NUM
admet-916	44	20	)	)	PUNCT
admet-916	44	21	57	57	NUM
admet-916	44	22	-	-	SYM
admet-916	44	23	68	68	NUM
admet-916	44	24	passive	passive	ADJ
admet-916	44	25	transport	transport	NOUN
admet-916	44	26	of	of	ADP
admet-916	44	27	ketoprofen	ketoprofen	NOUN
admet-916	44	28	and	and	CCONJ
admet-916	44	29	metformin	metformin	PROPN
admet-916	44	30	doi	doi	PROPN
admet-916	44	31	:	:	PUNCT
admet-916	44	32	http://dx.doi.org/10.5599/admet.916	http://dx.doi.org/10.5599/admet.916	PROPN
admet-916	44	33	59	59	NUM
admet-916	44	34	dihydrate	dihydrate	PROPN
admet-916	44	35	(	(	PUNCT
admet-916	44	36	kemika	kemika	NOUN
admet-916	44	37	,	,	PUNCT
admet-916	44	38	zagreb	zagreb	PROPN
admet-916	44	39	,	,	PUNCT
admet-916	44	40	croatia	croatia	PROPN
admet-916	44	41	)	)	PUNCT
admet-916	44	42	,	,	PUNCT
admet-916	44	43	cholesterol	cholesterol	NOUN
admet-916	44	44	(	(	PUNCT
admet-916	44	45	sarajevolijek	sarajevolijek	PROPN
admet-916	44	46	,	,	PUNCT
admet-916	44	47	sarajevo	sarajevo	PROPN
admet-916	44	48	,	,	PUNCT
admet-916	44	49	bosnia	bosnia	PROPN
admet-916	44	50	and	and	CCONJ
admet-916	44	51	herzegovina	herzegovina	PROPN
admet-916	44	52	)	)	PUNCT
admet-916	44	53	,	,	PUNCT
admet-916	44	54	potassium	potassium	NOUN
admet-916	44	55	dihydrogen	dihydrogen	NOUN
admet-916	44	56	phosphate	phosphate	NOUN
admet-916	44	57	(	(	PUNCT
admet-916	44	58	semikem	semikem	PROPN
admet-916	44	59	,	,	PUNCT
admet-916	44	60	sarajevo	sarajevo	PROPN
admet-916	44	61	,	,	PUNCT
admet-916	44	62	bosnia	bosnia	PROPN
admet-916	44	63	and	and	CCONJ
admet-916	44	64	herzegovina	herzegovina	PROPN
admet-916	44	65	)	)	PUNCT
admet-916	44	66	,	,	PUNCT
admet-916	44	67	disodium	disodium	NOUN
admet-916	44	68	hydrogen	hydrogen	NOUN
admet-916	44	69	phosphate	phosphate	NOUN
admet-916	44	70	(	(	PUNCT
admet-916	44	71	kemika	kemika	NOUN
admet-916	44	72	,	,	PUNCT
admet-916	44	73	zagreb	zagreb	PROPN
admet-916	44	74	,	,	PUNCT
admet-916	44	75	croatia	croatia	PROPN
admet-916	44	76	)	)	PUNCT
admet-916	44	77	,	,	PUNCT
admet-916	44	78	ketoprofen	ketoprofen	VERB
admet-916	44	79	,	,	PUNCT
admet-916	44	80	working	working	NOUN
admet-916	44	81	standard	standard	NOUN
admet-916	44	82	(	(	PUNCT
admet-916	44	83	lek	lek	PROPN
admet-916	44	84	,	,	PUNCT
admet-916	44	85	slovenia	slovenia	PROPN
admet-916	44	86	)	)	PUNCT
admet-916	44	87	,	,	PUNCT
admet-916	44	88	metformin	metformin	NOUN
admet-916	44	89	hydrochloride	hydrochloride	NOUN
admet-916	44	90	,	,	PUNCT
admet-916	44	91	reference	reference	NOUN
admet-916	44	92	standard	standard	NOUN
admet-916	44	93	(	(	PUNCT
admet-916	44	94	merck	merck	PROPN
admet-916	44	95	,	,	PUNCT
admet-916	44	96	darmstadt	darmstadt	PROPN
admet-916	44	97	,	,	PUNCT
admet-916	44	98	germany	germany	PROPN
admet-916	44	99	)	)	PUNCT
admet-916	44	100	,	,	PUNCT
admet-916	44	101	sodium	sodium	NOUN
admet-916	44	102	chloride	chloride	NOUN
admet-916	44	103	(	(	PUNCT
admet-916	44	104	merck	merck	PROPN
admet-916	44	105	,	,	PUNCT
admet-916	44	106	darmstadt	darmstadt	PROPN
admet-916	44	107	,	,	PUNCT
admet-916	44	108	germany	germany	PROPN
admet-916	44	109	)	)	PUNCT
admet-916	44	110	,	,	PUNCT
admet-916	44	111	n	n	CCONJ
admet-916	44	112	-	-	PUNCT
admet-916	44	113	octanol	octanol	NOUN
admet-916	44	114	(	(	PUNCT
admet-916	44	115	semikem	semikem	PROPN
admet-916	44	116	,	,	PUNCT
admet-916	44	117	sarajevo	sarajevo	PROPN
admet-916	44	118	,	,	PUNCT
admet-916	44	119	bosnia	bosnia	PROPN
admet-916	44	120	and	and	CCONJ
admet-916	44	121	herzegovina	herzegovina	PROPN
admet-916	44	122	)	)	PUNCT
admet-916	44	123	,	,	PUNCT
admet-916	44	124	hydrochloric	hydrochloric	ADJ
admet-916	44	125	acid	acid	NOUN
admet-916	44	126	(	(	PUNCT
admet-916	44	127	lach	lach	NOUN
admet-916	44	128	-	-	PUNCT
admet-916	44	129	ner	ner	NOUN
admet-916	44	130	,	,	PUNCT
admet-916	44	131	sro	sro	VERB
admet-916	44	132	neratovice	neratovice	NOUN
admet-916	44	133	,	,	PUNCT
admet-916	44	134	czech	czech	PROPN
admet-916	44	135	republic	republic	NOUN
admet-916	44	136	)	)	PUNCT
admet-916	44	137	,	,	PUNCT
admet-916	44	138	85	85	NUM
admet-916	44	139	%	%	NOUN
admet-916	44	140	phosphoric	phosphoric	NOUN
admet-916	44	141	acid	acid	NOUN
admet-916	44	142	(	(	PUNCT
admet-916	44	143	mallinckrodt	mallinckrodt	PROPN
admet-916	44	144	baker	baker	PROPN
admet-916	44	145	bv	bv	PROPN
admet-916	44	146	,	,	PUNCT
admet-916	44	147	deventer	deventer	PROPN
admet-916	44	148	,	,	PUNCT
admet-916	44	149	the	the	DET
admet-916	44	150	netherlands	netherlands	PROPN
admet-916	44	151	)	)	PUNCT
admet-916	44	152	.	.	PUNCT
admet-916	45	1	egg	egg	NOUN
admet-916	45	2	lecithin	lecithin	NOUN
admet-916	45	3	(	(	PUNCT
admet-916	45	4	lipoid	lipoid	PROPN
admet-916	45	5	®	®	NOUN
admet-916	45	6	e80	e80	VERB
admet-916	45	7	)	)	PUNCT
admet-916	45	8	was	be	AUX
admet-916	45	9	a	a	DET
admet-916	45	10	kind	kind	ADJ
admet-916	45	11	gift	gift	NOUN
admet-916	45	12	from	from	ADP
admet-916	45	13	lipoid	lipoid	PROPN
admet-916	45	14	gmbh	gmbh	PROPN
admet-916	45	15	,	,	PUNCT
admet-916	45	16	ludwigshafen	ludwigshafen	NOUN
admet-916	45	17	,	,	PUNCT
admet-916	45	18	germany	germany	PROPN
admet-916	45	19	.	.	PUNCT
admet-916	46	1	methods	method	NOUN
admet-916	46	2	in	in	ADP
admet-916	46	3	the	the	DET
admet-916	46	4	experimental	experimental	ADJ
admet-916	46	5	work	work	NOUN
admet-916	46	6	,	,	PUNCT
admet-916	46	7	the	the	DET
admet-916	46	8	instructions	instruction	NOUN
admet-916	46	9	for	for	ADP
admet-916	46	10	use	use	NOUN
admet-916	46	11	of	of	ADP
admet-916	46	12	the	the	DET
admet-916	46	13	apparatus	apparatus	NOUN
admet-916	46	14	absorption	absorption	NOUN
admet-916	46	15	simulator	simulator	NOUN
admet-916	46	16	sartorius	sartorius	NOUN
admet-916	46	17	model	model	NOUN
admet-916	46	18	sm	sm	PROPN
admet-916	46	19	16750	16750	NUM
admet-916	46	20	(	(	PUNCT
admet-916	46	21	sartorius	sartorius	NOUN
admet-916	46	22	membranfilter	membranfilter	NOUN
admet-916	46	23	gmbh	gmbh	PROPN
admet-916	46	24	,	,	PUNCT
admet-916	46	25	germany	germany	PROPN
admet-916	46	26	)	)	PUNCT
admet-916	46	27	and	and	CCONJ
admet-916	46	28	the	the	DET
admet-916	46	29	method	method	NOUN
admet-916	46	30	of	of	ADP
admet-916	46	31	the	the	DET
admet-916	46	32	authors	author	NOUN
admet-916	46	33	corti	corti	VERB
admet-916	46	34	et	et	PROPN
admet-916	46	35	al	al	PROPN
admet-916	46	36	.	.	PUNCT
admet-916	47	1	[	[	X
admet-916	47	2	1,15	1,15	X
admet-916	47	3	]	]	X
admet-916	47	4	and	and	CCONJ
admet-916	47	5	our	our	PRON
admet-916	47	6	study	study	NOUN
admet-916	47	7	group	group	NOUN
admet-916	47	8	[	[	X
admet-916	47	9	16	16	NUM
admet-916	47	10	]	]	PUNCT
admet-916	47	11	were	be	AUX
admet-916	47	12	used	use	VERB
admet-916	47	13	.	.	PUNCT
admet-916	48	1	cellulose	cellulose	NOUN
admet-916	48	2	nitrate	nitrate	NOUN
admet-916	48	3	filter	filter	NOUN
admet-916	48	4	(	(	PUNCT
admet-916	48	5	mixed	mixed	ADJ
admet-916	48	6	cellulose	cellulose	NOUN
admet-916	48	7	ester	ester	NOUN
admet-916	48	8	)	)	PUNCT
admet-916	48	9	,	,	PUNCT
admet-916	48	10	pore	pore	ADJ
admet-916	48	11	size	size	NOUN
admet-916	48	12	0.45	0.45	NUM
admet-916	48	13	µm	µm	NOUN
admet-916	48	14	(	(	PUNCT
admet-916	48	15	sartorius	sartorius	NOUN
admet-916	48	16	ag	ag	PROPN
admet-916	48	17	,	,	PUNCT
admet-916	48	18	göttingen	göttingen	NOUN
admet-916	48	19	,	,	PUNCT
admet-916	48	20	germany	germany	PROPN
admet-916	48	21	)	)	PUNCT
admet-916	48	22	was	be	AUX
admet-916	48	23	impregnated	impregnate	VERB
admet-916	48	24	with	with	ADP
admet-916	48	25	2	2	NUM
admet-916	48	26	ml	ml	NOUN
admet-916	48	27	solution	solution	NOUN
admet-916	48	28	of	of	ADP
admet-916	48	29	2.10	2.10	NUM
admet-916	48	30	%	%	NOUN
admet-916	48	31	cholesterol	cholesterol	NOUN
admet-916	48	32	and	and	CCONJ
admet-916	48	33	1.70	1.70	NUM
admet-916	48	34	%	%	NOUN
admet-916	48	35	egg	egg	NOUN
admet-916	48	36	lecithin	lecithin	NOUN
admet-916	48	37	(	(	PUNCT
admet-916	48	38	lipoid	lipoid	NOUN
admet-916	48	39	®	®	NOUN
admet-916	48	40	e	e	X
admet-916	48	41	80	80	NUM
admet-916	48	42	)	)	PUNCT
admet-916	48	43	in	in	ADP
admet-916	48	44	n	n	CCONJ
admet-916	48	45	-	-	PUNCT
admet-916	48	46	octanol	octanol	NOUN
admet-916	48	47	for	for	ADP
admet-916	48	48	10	10	NUM
admet-916	48	49	minutes	minute	NOUN
admet-916	48	50	.	.	PUNCT
admet-916	49	1	the	the	DET
admet-916	49	2	excess	excess	ADJ
admet-916	49	3	impregnation	impregnation	NOUN
admet-916	49	4	solution	solution	NOUN
admet-916	49	5	was	be	AUX
admet-916	49	6	removed	remove	VERB
admet-916	49	7	by	by	ADP
admet-916	49	8	pressing	press	VERB
admet-916	49	9	a	a	DET
admet-916	49	10	filter	filter	NOUN
admet-916	49	11	located	locate	VERB
admet-916	49	12	between	between	ADP
admet-916	49	13	the	the	DET
admet-916	49	14	two	two	NUM
admet-916	49	15	absorbent	absorbent	ADJ
admet-916	49	16	papers	paper	NOUN
admet-916	49	17	.	.	PUNCT
admet-916	50	1	the	the	DET
admet-916	50	2	mass	mass	NOUN
admet-916	50	3	of	of	ADP
admet-916	50	4	the	the	DET
admet-916	50	5	filter	filter	NOUN
admet-916	50	6	before	before	ADV
admet-916	50	7	and	and	CCONJ
admet-916	50	8	after	after	ADP
admet-916	50	9	impregnation	impregnation	NOUN
admet-916	50	10	was	be	AUX
admet-916	50	11	determined	determine	VERB
admet-916	50	12	using	use	VERB
admet-916	50	13	an	an	DET
admet-916	50	14	analytical	analytical	ADJ
admet-916	50	15	balance	balance	NOUN
admet-916	50	16	(	(	PUNCT
admet-916	50	17	ag	ag	PROPN
admet-916	50	18	400	400	NUM
admet-916	50	19	,	,	PUNCT
admet-916	50	20	metler	metler	PROPN
admet-916	50	21	toledo	toledo	PROPN
admet-916	50	22	gmbh	gmbh	PROPN
admet-916	50	23	,	,	PUNCT
admet-916	50	24	switzerland	switzerland	PROPN
admet-916	50	25	)	)	PUNCT
admet-916	50	26	from	from	ADP
admet-916	50	27	which	which	PRON
admet-916	50	28	the	the	DET
admet-916	50	29	percentage	percentage	NOUN
admet-916	50	30	of	of	ADP
admet-916	50	31	impregnation	impregnation	NOUN
admet-916	50	32	solution	solution	NOUN
admet-916	50	33	retained	retain	VERB
admet-916	50	34	on	on	ADP
admet-916	50	35	the	the	DET
admet-916	50	36	filter	filter	NOUN
admet-916	50	37	was	be	AUX
admet-916	50	38	calculated	calculate	VERB
admet-916	50	39	as	as	ADP
admet-916	50	40	filter	filter	NOUN
admet-916	50	41	mass	mass	NOUN
admet-916	50	42	increase	increase	NOUN
admet-916	50	43	.	.	PUNCT
admet-916	51	1	the	the	DET
admet-916	51	2	filter	filter	NOUN
admet-916	51	3	prepared	prepare	VERB
admet-916	51	4	in	in	ADP
admet-916	51	5	this	this	DET
admet-916	51	6	way	way	NOUN
admet-916	51	7	was	be	AUX
admet-916	51	8	placed	place	VERB
admet-916	51	9	in	in	ADP
admet-916	51	10	a	a	DET
admet-916	51	11	diffusion	diffusion	NOUN
admet-916	51	12	cell	cell	NOUN
admet-916	51	13	of	of	ADP
admet-916	51	14	absorption	absorption	NOUN
admet-916	51	15	simulator	simulator	NOUN
admet-916	51	16	connected	connect	VERB
admet-916	51	17	to	to	ADP
admet-916	51	18	the	the	DET
admet-916	51	19	donor	donor	NOUN
admet-916	51	20	and	and	CCONJ
admet-916	51	21	acceptor	acceptor	NOUN
admet-916	51	22	compartments	compartment	NOUN
admet-916	51	23	.	.	PUNCT
admet-916	52	1	the	the	DET
admet-916	52	2	donor	donor	NOUN
admet-916	52	3	compartment	compartment	NOUN
admet-916	52	4	contained	contain	VERB
admet-916	52	5	a	a	DET
admet-916	52	6	solution	solution	NOUN
admet-916	52	7	of	of	ADP
admet-916	52	8	500	500	NUM
admet-916	52	9	µmol	µmol	ADV
admet-916	52	10	l-1	l-1	NOUN
admet-916	52	11	of	of	ADP
admet-916	52	12	active	active	ADJ
admet-916	52	13	substance	substance	NOUN
admet-916	52	14	(	(	PUNCT
admet-916	52	15	ketoprofen	ketoprofen	VERB
admet-916	52	16	or	or	CCONJ
admet-916	52	17	metformin	metformin	NOUN
admet-916	52	18	)	)	PUNCT
admet-916	52	19	in	in	ADP
admet-916	52	20	100	100	NUM
admet-916	52	21	ml	ml	NOUN
admet-916	52	22	of	of	ADP
admet-916	52	23	phosphate	phosphate	ADJ
admet-916	52	24	buffer	buffer	NOUN
admet-916	52	25	of	of	ADP
admet-916	52	26	different	different	ADJ
admet-916	52	27	ph	ph	ADJ
admet-916	52	28	values	value	NOUN
admet-916	52	29	.	.	PUNCT
admet-916	53	1	the	the	DET
admet-916	53	2	ph	ph	ADJ
admet-916	53	3	values	value	NOUN
admet-916	53	4	of	of	ADP
admet-916	53	5	the	the	DET
admet-916	53	6	buffer	buffer	NOUN
admet-916	53	7	in	in	ADP
admet-916	53	8	the	the	DET
admet-916	53	9	donor	donor	NOUN
admet-916	53	10	compartment	compartment	NOUN
admet-916	53	11	were	be	AUX
admet-916	53	12	:	:	PUNCT
admet-916	53	13	7.4	7.4	NUM
admet-916	53	14	,	,	PUNCT
admet-916	53	15	6.8	6.8	NUM
admet-916	53	16	,	,	PUNCT
admet-916	53	17	4.5	4.5	NUM
admet-916	53	18	and	and	CCONJ
admet-916	53	19	3.0	3.0	NUM
admet-916	53	20	or	or	CCONJ
admet-916	53	21	2.0	2.0	NUM
admet-916	53	22	for	for	ADP
admet-916	53	23	ketoprofen	ketoprofen	NOUN
admet-916	53	24	or	or	CCONJ
admet-916	53	25	metformin	metformin	NOUN
admet-916	53	26	,	,	PUNCT
admet-916	53	27	respectively	respectively	ADV
admet-916	53	28	.	.	PUNCT
admet-916	54	1	phosphate	phosphate	ADJ
admet-916	54	2	buffer	buffer	NOUN
admet-916	54	3	of	of	ADP
admet-916	54	4	ph	ph	ADJ
admet-916	54	5	7.4	7.4	NUM
admet-916	54	6	was	be	AUX
admet-916	54	7	present	present	ADJ
admet-916	54	8	in	in	ADP
admet-916	54	9	the	the	DET
admet-916	54	10	acceptor	acceptor	NOUN
admet-916	54	11	compartment	compartment	NOUN
admet-916	54	12	in	in	ADP
admet-916	54	13	all	all	DET
admet-916	54	14	experiments	experiment	NOUN
admet-916	54	15	.	.	PUNCT
admet-916	55	1	the	the	DET
admet-916	55	2	temperature	temperature	NOUN
admet-916	55	3	in	in	ADP
admet-916	55	4	both	both	DET
admet-916	55	5	compartments	compartment	NOUN
admet-916	55	6	was	be	AUX
admet-916	55	7	measured	measure	VERB
admet-916	55	8	and	and	CCONJ
admet-916	55	9	maintained	maintain	VERB
admet-916	55	10	at	at	ADP
admet-916	55	11	37	37	NUM
admet-916	55	12	±	±	NUM
admet-916	55	13	0.5	0.5	NUM
admet-916	55	14	°	°	ADP
admet-916	55	15	c	c	NOUN
admet-916	55	16	.	.	PUNCT
admet-916	56	1	under	under	ADP
admet-916	56	2	the	the	DET
admet-916	56	3	action	action	NOUN
admet-916	56	4	of	of	ADP
admet-916	56	5	the	the	DET
admet-916	56	6	peristaltic	peristaltic	ADJ
admet-916	56	7	pump	pump	NOUN
admet-916	56	8	,	,	PUNCT
admet-916	56	9	the	the	DET
admet-916	56	10	contents	content	NOUN
admet-916	56	11	of	of	ADP
admet-916	56	12	the	the	DET
admet-916	56	13	donor	donor	NOUN
admet-916	56	14	and	and	CCONJ
admet-916	56	15	acceptor	acceptor	NOUN
admet-916	56	16	compartment	compartment	NOUN
admet-916	56	17	were	be	AUX
admet-916	56	18	constantly	constantly	ADV
admet-916	56	19	circulating	circulate	VERB
admet-916	56	20	through	through	ADP
admet-916	56	21	the	the	DET
admet-916	56	22	diffusion	diffusion	NOUN
admet-916	56	23	cell	cell	NOUN
admet-916	56	24	on	on	ADP
admet-916	56	25	both	both	DET
admet-916	56	26	sides	side	NOUN
admet-916	56	27	of	of	ADP
admet-916	56	28	the	the	DET
admet-916	56	29	membrane	membrane	NOUN
admet-916	56	30	(	(	PUNCT
admet-916	56	31	figure	figure	NOUN
admet-916	56	32	1	1	NUM
admet-916	56	33	)	)	PUNCT
admet-916	56	34	.	.	PUNCT
admet-916	57	1	at	at	ADP
admet-916	57	2	30	30	NUM
admet-916	57	3	,	,	PUNCT
admet-916	57	4	60	60	NUM
admet-916	57	5	,	,	PUNCT
admet-916	57	6	90	90	NUM
admet-916	57	7	and	and	CCONJ
admet-916	57	8	120	120	NUM
admet-916	57	9	minutes	minute	NOUN
admet-916	57	10	,	,	PUNCT
admet-916	57	11	sampling	sample	VERB
admet-916	57	12	was	be	AUX
admet-916	57	13	performed	perform	VERB
admet-916	57	14	from	from	ADP
admet-916	57	15	the	the	DET
admet-916	57	16	acceptor	acceptor	NOUN
admet-916	57	17	compartment	compartment	NOUN
admet-916	57	18	and	and	CCONJ
admet-916	57	19	the	the	DET
admet-916	57	20	concentration	concentration	NOUN
admet-916	57	21	of	of	ADP
admet-916	57	22	active	active	ADJ
admet-916	57	23	substances	substance	NOUN
admet-916	57	24	(	(	PUNCT
admet-916	57	25	ketoprofen	ketoprofen	VERB
admet-916	57	26	or	or	CCONJ
admet-916	57	27	metformin	metformin	NOUN
admet-916	57	28	)	)	PUNCT
admet-916	57	29	was	be	AUX
admet-916	57	30	determined	determine	VERB
admet-916	57	31	spectrophotometrically	spectrophotometrically	ADV
admet-916	57	32	.	.	PUNCT
admet-916	58	1	spectrophotometric	spectrophotometric	ADJ
admet-916	58	2	measurements	measurement	NOUN
admet-916	58	3	were	be	AUX
admet-916	58	4	performed	perform	VERB
admet-916	58	5	on	on	ADP
admet-916	58	6	uv	uv	NOUN
admet-916	58	7	-	-	PUNCT
admet-916	58	8	vis	vis	X
admet-916	58	9	spectrophotometer	spectrophotometer	NOUN
admet-916	58	10	uv-1601	uv-1601	PROPN
admet-916	58	11	(	(	PUNCT
admet-916	58	12	shimadzu	shimadzu	PROPN
admet-916	58	13	,	,	PUNCT
admet-916	58	14	kyoto	kyoto	PROPN
admet-916	58	15	,	,	PUNCT
admet-916	58	16	japan	japan	PROPN
admet-916	58	17	)	)	PUNCT
admet-916	58	18	.	.	PUNCT
admet-916	59	1	the	the	DET
admet-916	59	2	method	method	NOUN
admet-916	59	3	was	be	AUX
admet-916	59	4	validated	validate	VERB
admet-916	59	5	prior	prior	ADV
admet-916	59	6	to	to	ADP
admet-916	59	7	the	the	DET
admet-916	59	8	permeation	permeation	NOUN
admet-916	59	9	experiments	experiment	NOUN
admet-916	59	10	according	accord	VERB
admet-916	59	11	to	to	ADP
admet-916	59	12	ich	ich	PROPN
admet-916	59	13	guideline	guideline	PROPN
admet-916	59	14	q2	q2	PROPN
admet-916	59	15	-	-	PUNCT
admet-916	59	16	r1	r1	PROPN
admet-916	60	1	[	[	X
admet-916	60	2	17	17	NUM
admet-916	60	3	]	]	PUNCT
admet-916	60	4	.	.	PUNCT
admet-916	61	1	after	after	ADP
admet-916	61	2	reading	read	VERB
admet-916	61	3	the	the	DET
admet-916	61	4	results	result	NOUN
admet-916	61	5	on	on	ADP
admet-916	61	6	the	the	DET
admet-916	61	7	spectrophotometer	spectrophotometer	NOUN
admet-916	61	8	,	,	PUNCT
admet-916	61	9	the	the	DET
admet-916	61	10	samples	sample	NOUN
admet-916	61	11	were	be	AUX
admet-916	61	12	returned	return	VERB
admet-916	61	13	to	to	ADP
admet-916	61	14	the	the	DET
admet-916	61	15	acceptor	acceptor	NOUN
admet-916	61	16	compartment	compartment	NOUN
admet-916	61	17	.	.	PUNCT
admet-916	62	1	at	at	ADP
admet-916	62	2	the	the	DET
admet-916	62	3	end	end	NOUN
admet-916	62	4	(	(	PUNCT
admet-916	62	5	120	120	NUM
admet-916	62	6	minutes	minute	NOUN
admet-916	62	7	)	)	PUNCT
admet-916	62	8	,	,	PUNCT
admet-916	62	9	the	the	DET
admet-916	62	10	samples	sample	NOUN
admet-916	62	11	were	be	AUX
admet-916	62	12	also	also	ADV
admet-916	62	13	taken	take	VERB
admet-916	62	14	from	from	ADP
admet-916	62	15	donor	donor	NOUN
admet-916	62	16	compartment	compartment	NOUN
admet-916	62	17	,	,	PUNCT
admet-916	62	18	and	and	CCONJ
admet-916	62	19	concentration	concentration	NOUN
admet-916	62	20	of	of	ADP
admet-916	62	21	ketoprofen	ketoprofen	NOUN
admet-916	62	22	or	or	CCONJ
admet-916	62	23	metformin	metformin	NOUN
admet-916	62	24	was	be	AUX
admet-916	62	25	determined	determine	VERB
admet-916	62	26	spectrophotometrically	spectrophotometrically	ADV
admet-916	62	27	.	.	PUNCT
admet-916	63	1	this	this	DET
admet-916	63	2	data	datum	NOUN
admet-916	63	3	was	be	AUX
admet-916	63	4	used	use	VERB
admet-916	63	5	to	to	PART
admet-916	63	6	calculate	calculate	VERB
admet-916	63	7	the	the	DET
admet-916	63	8	recovery	recovery	NOUN
admet-916	63	9	value	value	NOUN
admet-916	63	10	(	(	PUNCT
admet-916	63	11	r	r	NOUN
admet-916	63	12	)	)	PUNCT
admet-916	63	13	.	.	PUNCT
admet-916	64	1	each	each	DET
admet-916	64	2	experiment	experiment	NOUN
admet-916	64	3	was	be	AUX
admet-916	64	4	performed	perform	VERB
admet-916	64	5	in	in	ADP
admet-916	64	6	triplicate	triplicate	NOUN
admet-916	64	7	.	.	PUNCT
admet-916	65	1	from	from	ADP
admet-916	65	2	the	the	DET
admet-916	65	3	samples	sample	NOUN
admet-916	65	4	taken	take	VERB
admet-916	65	5	from	from	ADP
admet-916	65	6	the	the	DET
admet-916	65	7	acceptor	acceptor	NOUN
admet-916	65	8	compartment	compartment	NOUN
admet-916	65	9	,	,	PUNCT
admet-916	65	10	the	the	DET
admet-916	65	11	apparent	apparent	ADJ
admet-916	65	12	permeability	permeability	NOUN
admet-916	65	13	coefficients	coefficient	NOUN
admet-916	65	14	of	of	ADP
admet-916	65	15	ketoprofen	ketoprofen	NOUN
admet-916	65	16	and	and	CCONJ
admet-916	65	17	metformin	metformin	NOUN
admet-916	65	18	were	be	AUX
admet-916	65	19	calculated	calculate	VERB
admet-916	65	20	based	base	VERB
admet-916	65	21	on	on	ADP
admet-916	65	22	equation	equation	NOUN
admet-916	65	23	1	1	NUM
admet-916	65	24	:	:	SYM
admet-916	65	25	0	0	NUM
admet-916	65	26	1	1	NUM
admet-916	65	27	app	app	NOUN
admet-916	65	28	dq	dq	ADP
admet-916	65	29	p	p	X
admet-916	65	30	dt	dt	INTJ
admet-916	65	31	ac	ac	PROPN
admet-916	66	1			PROPN
admet-916	66	2	,	,	PUNCT
admet-916	66	3	(	(	PUNCT
admet-916	66	4	1	1	X
admet-916	66	5	)	)	PUNCT
admet-916	67	1	where	where	SCONJ
admet-916	67	2	papp	papp	NOUN
admet-916	67	3	apparent	apparent	ADJ
admet-916	67	4	permeation	permeation	NOUN
admet-916	67	5	coefficient	coefficient	NOUN
admet-916	67	6	,	,	PUNCT
admet-916	67	7	cm	cm	NOUN
admet-916	67	8	s-1	s-1	NOUN
admet-916	67	9	;	;	PUNCT
admet-916	67	10	dq	dq	PROPN
admet-916	67	11	/	/	SYM
admet-916	67	12	dt	dt	NOUN
admet-916	67	13	mass	mass	NOUN
admet-916	67	14	of	of	ADP
admet-916	67	15	the	the	DET
admet-916	67	16	substance	substance	NOUN
admet-916	67	17	that	that	PRON
admet-916	67	18	passed	pass	VERB
admet-916	67	19	through	through	ADP
admet-916	67	20	the	the	DET
admet-916	67	21	membrane	membrane	NOUN
admet-916	67	22	per	per	ADP
admet-916	67	23	unit	unit	NOUN
admet-916	67	24	time	time	NOUN
admet-916	67	25	,	,	PUNCT
admet-916	67	26	mg	mg	PROPN
admet-916	67	27	s-1	s-1	PROPN
admet-916	67	28	;	;	PUNCT
admet-916	67	29	a	a	DET
admet-916	67	30	effective	effective	ADJ
admet-916	67	31	surface	surface	NOUN
admet-916	67	32	of	of	ADP
admet-916	67	33	the	the	DET
admet-916	67	34	artificial	artificial	ADJ
admet-916	67	35	membrane	membrane	NOUN
admet-916	67	36	through	through	ADP
admet-916	67	37	which	which	PRON
admet-916	67	38	the	the	DET
admet-916	67	39	permeation	permeation	NOUN
admet-916	67	40	was	be	AUX
admet-916	67	41	examined	examine	VERB
admet-916	67	42	,	,	PUNCT
admet-916	67	43	cm2	cm2	NOUN
admet-916	67	44	;	;	PUNCT
admet-916	67	45	c0	c0	PROPN
admet-916	67	46	initial	initial	ADJ
admet-916	67	47	concentration	concentration	NOUN
admet-916	67	48	of	of	ADP
admet-916	67	49	active	active	ADJ
admet-916	67	50	substance	substance	NOUN
admet-916	67	51	in	in	ADP
admet-916	67	52	donor	donor	NOUN
admet-916	67	53	solution	solution	NOUN
admet-916	67	54	,	,	PUNCT
admet-916	67	55	mg	mg	PROPN
admet-916	67	56	ml-1	ml-1	PROPN
admet-916	67	57	.	.	PROPN
admet-916	68	1	http://dx.doi.org/10.5599/admet.916	http://dx.doi.org/10.5599/admet.916	PROPN
admet-916	68	2	alisa	alisa	PROPN
admet-916	68	3	elezović	elezović	PROPN
admet-916	68	4	et	et	PROPN
admet-916	68	5	al	al	PROPN
admet-916	68	6	.	.	PROPN
admet-916	68	7	admet	admet	PROPN
admet-916	68	8	&	&	CCONJ
admet-916	68	9	dmpk	dmpk	PROPN
admet-916	68	10	9(1	9(1	NUM
admet-916	68	11	)	)	PUNCT
admet-916	68	12	(	(	PUNCT
admet-916	68	13	2021	2021	NUM
admet-916	68	14	)	)	PUNCT
admet-916	68	15	57	57	NUM
admet-916	68	16	-	-	SYM
admet-916	68	17	68	68	NUM
admet-916	68	18	60	60	NUM
admet-916	68	19	figure	figure	NOUN
admet-916	68	20	1	1	NUM
admet-916	68	21	.	.	PUNCT
admet-916	69	1	absorption	absorption	NOUN
admet-916	69	2	simulator	simulator	NOUN
admet-916	69	3	sartorius	sartorius	NOUN
admet-916	69	4	model	model	NOUN
admet-916	69	5	sm	sm	PROPN
admet-916	69	6	16750	16750	NUM
admet-916	69	7	recovery	recovery	NOUN
admet-916	69	8	of	of	ADP
admet-916	69	9	ketoprofen	ketoprofen	NOUN
admet-916	69	10	and	and	CCONJ
admet-916	69	11	metformin	metformin	NOUN
admet-916	69	12	(	(	PUNCT
admet-916	69	13	as	as	ADP
admet-916	69	14	a	a	DET
admet-916	69	15	percentage	percentage	NOUN
admet-916	69	16	of	of	ADP
admet-916	69	17	the	the	DET
admet-916	69	18	substance	substance	NOUN
admet-916	69	19	not	not	PART
admet-916	69	20	retained	retain	VERB
admet-916	69	21	in	in	ADP
admet-916	69	22	the	the	DET
admet-916	69	23	membrane	membrane	NOUN
admet-916	69	24	)	)	PUNCT
admet-916	69	25	was	be	AUX
admet-916	69	26	determined	determine	VERB
admet-916	69	27	according	accord	VERB
admet-916	69	28	to	to	ADP
admet-916	69	29	equation	equation	NOUN
admet-916	69	30	2	2	NUM
admet-916	69	31	:	:	PUNCT
admet-916	69	32	,	,	PUNCT
admet-916	69	33	,	,	PUNCT
admet-916	69	34	,	,	PUNCT
admet-916	69	35	0	0	NUM
admet-916	69	36	%	%	NOUN
admet-916	69	37	x	x	SYM
admet-916	69	38	100a	100a	NOUN
admet-916	69	39	end	end	VERB
admet-916	69	40	a	a	DET
admet-916	69	41	d	d	NOUN
admet-916	69	42	end	end	NOUN
admet-916	70	1	d	d	X
admet-916	70	2	d	d	PROPN
admet-916	70	3	d	d	X
admet-916	70	4	c	c	PROPN
admet-916	70	5	v	v	NOUN
admet-916	70	6	c	c	NOUN
admet-916	70	7	v	v	NOUN
admet-916	70	8	r	r	NOUN
admet-916	70	9	c	c	NOUN
admet-916	70	10	v	v	ADP
admet-916	70	11			PROPN
admet-916	70	12			NUM
admet-916	70	13	,	,	PUNCT
admet-916	70	14	(	(	PUNCT
admet-916	70	15	2	2	X
admet-916	70	16	)	)	PUNCT
admet-916	70	17	where	where	SCONJ
admet-916	70	18	ca	can	AUX
admet-916	70	19	,	,	PUNCT
admet-916	70	20	end	end	NOUN
admet-916	70	21	and	and	CCONJ
admet-916	70	22	cd	cd	PROPN
admet-916	70	23	,	,	PUNCT
admet-916	70	24	end	end	VERB
admet-916	70	25	concentration	concentration	NOUN
admet-916	70	26	of	of	ADP
admet-916	70	27	test	test	NOUN
admet-916	70	28	substance	substance	NOUN
admet-916	70	29	measured	measure	VERB
admet-916	70	30	at	at	ADP
admet-916	70	31	the	the	DET
admet-916	70	32	end	end	NOUN
admet-916	70	33	of	of	ADP
admet-916	70	34	the	the	DET
admet-916	70	35	experiment	experiment	NOUN
admet-916	70	36	in	in	ADP
admet-916	70	37	acceptor	acceptor	NOUN
admet-916	70	38	and	and	CCONJ
admet-916	70	39	donor	donor	NOUN
admet-916	70	40	solution	solution	NOUN
admet-916	70	41	,	,	PUNCT
admet-916	70	42	mg	mg	PROPN
admet-916	70	43	ml	ml	NOUN
admet-916	70	44	-1	-1	PRON
admet-916	70	45	;	;	PUNCT
admet-916	70	46	cd,0	cd,0	NOUN
admet-916	70	47	initial	initial	ADJ
admet-916	70	48	concentration	concentration	NOUN
admet-916	70	49	of	of	ADP
admet-916	70	50	test	test	NOUN
admet-916	70	51	substance	substance	NOUN
admet-916	70	52	in	in	ADP
admet-916	70	53	donor	donor	NOUN
admet-916	70	54	solution	solution	NOUN
admet-916	70	55	,	,	PUNCT
admet-916	70	56	mg	mg	PROPN
admet-916	70	57	ml	ml	PROPN
admet-916	70	58	-1	-1	ADP
admet-916	70	59	;	;	PUNCT
admet-916	70	60	va	va	NOUN
admet-916	70	61	and	and	CCONJ
admet-916	70	62	vd	vd	NOUN
admet-916	70	63	volumes	volume	NOUN
admet-916	70	64	of	of	ADP
admet-916	70	65	acceptor	acceptor	NOUN
admet-916	70	66	and	and	CCONJ
admet-916	70	67	donor	donor	NOUN
admet-916	70	68	solution	solution	NOUN
admet-916	70	69	,	,	PUNCT
admet-916	70	70	ml	ml	X
admet-916	70	71	.	.	PUNCT
admet-916	70	72	results	result	NOUN
admet-916	70	73	and	and	CCONJ
admet-916	70	74	discussion	discussion	NOUN
admet-916	70	75	permeations	permeation	NOUN
admet-916	70	76	of	of	ADP
admet-916	70	77	ketoprofen	ketoprofen	NOUN
admet-916	70	78	and	and	CCONJ
admet-916	70	79	metformin	metformin	NOUN
admet-916	70	80	were	be	AUX
admet-916	70	81	monitored	monitor	VERB
admet-916	70	82	in	in	ADP
admet-916	70	83	this	this	DET
admet-916	70	84	experimental	experimental	ADJ
admet-916	70	85	work	work	NOUN
admet-916	70	86	at	at	ADP
admet-916	70	87	different	different	ADJ
admet-916	70	88	ph	ph	ADJ
admet-916	70	89	values	value	NOUN
admet-916	70	90	of	of	ADP
admet-916	70	91	the	the	DET
admet-916	70	92	donor	donor	NOUN
admet-916	70	93	compartment	compartment	NOUN
admet-916	70	94	,	,	PUNCT
admet-916	70	95	while	while	SCONJ
admet-916	70	96	the	the	DET
admet-916	70	97	ph	ph	NOUN
admet-916	70	98	of	of	ADP
admet-916	70	99	the	the	DET
admet-916	70	100	acceptor	acceptor	NOUN
admet-916	70	101	compartment	compartment	NOUN
admet-916	70	102	was	be	AUX
admet-916	70	103	7.4	7.4	NUM
admet-916	70	104	in	in	ADP
admet-916	70	105	all	all	DET
admet-916	70	106	cases	case	NOUN
admet-916	70	107	.	.	PUNCT
admet-916	71	1	in	in	ADP
admet-916	71	2	this	this	DET
admet-916	71	3	way	way	NOUN
admet-916	71	4	,	,	PUNCT
admet-916	71	5	it	it	PRON
admet-916	71	6	was	be	AUX
admet-916	71	7	possible	possible	ADJ
admet-916	71	8	to	to	PART
admet-916	71	9	examine	examine	VERB
admet-916	71	10	the	the	DET
admet-916	71	11	permeation	permeation	NOUN
admet-916	71	12	of	of	ADP
admet-916	71	13	the	the	DET
admet-916	71	14	substances	substance	NOUN
admet-916	71	15	from	from	ADP
admet-916	71	16	the	the	DET
admet-916	71	17	donor	donor	NOUN
admet-916	71	18	compartment	compartment	NOUN
admet-916	71	19	at	at	ADP
admet-916	71	20	different	different	ADJ
admet-916	71	21	ph	ph	ADJ
admet-916	71	22	values	value	NOUN
admet-916	71	23	,	,	PUNCT
admet-916	71	24	which	which	PRON
admet-916	71	25	simulated	simulate	VERB
admet-916	71	26	git	git	NOUN
admet-916	71	27	conditions	condition	NOUN
admet-916	71	28	across	across	ADP
admet-916	71	29	an	an	DET
admet-916	71	30	artificial	artificial	ADJ
admet-916	71	31	membrane	membrane	NOUN
admet-916	71	32	embedded	embed	VERB
admet-916	71	33	in	in	ADP
admet-916	71	34	a	a	DET
admet-916	71	35	diffusion	diffusion	NOUN
admet-916	71	36	cell	cell	NOUN
admet-916	71	37	in	in	ADP
admet-916	71	38	the	the	DET
admet-916	71	39	acceptor	acceptor	NOUN
admet-916	71	40	compartment	compartment	NOUN
admet-916	71	41	that	that	PRON
admet-916	71	42	reflected	reflect	VERB
admet-916	71	43	the	the	DET
admet-916	71	44	ph	ph	ADJ
admet-916	71	45	conditions	condition	NOUN
admet-916	71	46	of	of	ADP
admet-916	71	47	the	the	DET
admet-916	71	48	systemic	systemic	ADJ
admet-916	71	49	circulation	circulation	NOUN
admet-916	71	50	.	.	PUNCT
admet-916	72	1	a	a	DET
admet-916	72	2	membrane	membrane	NOUN
admet-916	72	3	filter	filter	NOUN
admet-916	72	4	with	with	ADP
admet-916	72	5	pore	pore	ADJ
admet-916	72	6	size	size	NOUN
admet-916	72	7	of	of	ADP
admet-916	72	8	0.45	0.45	NUM
admet-916	72	9	µm	µm	NOUN
admet-916	72	10	was	be	AUX
admet-916	72	11	used	use	VERB
admet-916	72	12	in	in	ADP
admet-916	72	13	this	this	DET
admet-916	72	14	work	work	NOUN
admet-916	72	15	.	.	PUNCT
admet-916	73	1	as	as	SCONJ
admet-916	73	2	we	we	PRON
admet-916	73	3	mentioned	mention	VERB
admet-916	73	4	in	in	ADP
admet-916	73	5	the	the	DET
admet-916	73	6	earlier	early	ADJ
admet-916	73	7	work	work	NOUN
admet-916	73	8	[	[	X
admet-916	73	9	16	16	NUM
admet-916	73	10	]	]	PUNCT
admet-916	73	11	the	the	DET
admet-916	73	12	pore	pore	ADJ
admet-916	73	13	size	size	NOUN
admet-916	73	14	of	of	ADP
admet-916	73	15	the	the	DET
admet-916	73	16	membrane	membrane	NOUN
admet-916	73	17	filter	filter	NOUN
admet-916	73	18	does	do	AUX
admet-916	73	19	not	not	PART
admet-916	73	20	affect	affect	VERB
admet-916	73	21	the	the	DET
admet-916	73	22	permeability	permeability	NOUN
admet-916	73	23	of	of	ADP
admet-916	73	24	active	active	ADJ
admet-916	73	25	substances	substance	NOUN
admet-916	73	26	across	across	ADP
admet-916	73	27	the	the	DET
admet-916	73	28	artificial	artificial	ADJ
admet-916	73	29	membrane	membrane	NOUN
admet-916	73	30	,	,	PUNCT
admet-916	73	31	since	since	SCONJ
admet-916	73	32	in	in	ADP
admet-916	73	33	corti	corti	PROPN
admet-916	73	34	et	et	PROPN
admet-916	73	35	al	al	PROPN
admet-916	73	36	.	.	PUNCT
admet-916	74	1	[	[	X
admet-916	74	2	1	1	X
admet-916	74	3	]	]	PUNCT
admet-916	74	4	there	there	PRON
admet-916	74	5	was	be	VERB
admet-916	74	6	no	no	DET
admet-916	74	7	clear	clear	ADJ
admet-916	74	8	causal	causal	ADJ
admet-916	74	9	relationship	relationship	NOUN
admet-916	74	10	between	between	ADP
admet-916	74	11	papp	papp	NOUN
admet-916	74	12	and	and	CCONJ
admet-916	74	13	pore	pore	ADJ
admet-916	74	14	sizes	size	NOUN
admet-916	74	15	established	establish	VERB
admet-916	74	16	.	.	PUNCT
admet-916	75	1	according	accord	VERB
admet-916	75	2	to	to	ADP
admet-916	75	3	the	the	DET
admet-916	75	4	instructions	instruction	NOUN
admet-916	75	5	for	for	ADP
admet-916	75	6	use	use	NOUN
admet-916	75	7	of	of	ADP
admet-916	75	8	the	the	DET
admet-916	75	9	apparatus	apparatus	NOUN
admet-916	75	10	(	(	PUNCT
admet-916	75	11	sartorius	sartorius	NOUN
admet-916	75	12	model	model	NOUN
admet-916	75	13	sm	sm	PROPN
admet-916	75	14	16750	16750	NUM
admet-916	75	15	)	)	PUNCT
admet-916	75	16	,	,	PUNCT
admet-916	75	17	the	the	DET
admet-916	75	18	increase	increase	NOUN
admet-916	75	19	in	in	ADP
admet-916	75	20	filter	filter	NOUN
admet-916	75	21	weight	weight	NOUN
admet-916	75	22	after	after	ADP
admet-916	75	23	impregnation	impregnation	NOUN
admet-916	75	24	should	should	AUX
admet-916	75	25	be	be	AUX
admet-916	75	26	100	100	NUM
admet-916	75	27	±	±	NUM
admet-916	75	28	5	5	NUM
admet-916	75	29	%	%	NOUN
admet-916	75	30	.	.	PUNCT
admet-916	76	1	the	the	DET
admet-916	76	2	mean	mean	ADJ
admet-916	76	3	value	value	NOUN
admet-916	76	4	of	of	ADP
admet-916	76	5	the	the	DET
admet-916	76	6	percentage	percentage	NOUN
admet-916	76	7	of	of	ADP
admet-916	76	8	impregnation	impregnation	NOUN
admet-916	76	9	of	of	ADP
admet-916	76	10	the	the	DET
admet-916	76	11	membrane	membrane	NOUN
admet-916	76	12	,	,	PUNCT
admet-916	76	13	i.e.	i.e.	X
admet-916	76	14	the	the	DET
admet-916	76	15	average	average	ADJ
admet-916	76	16	increase	increase	NOUN
admet-916	76	17	in	in	ADP
admet-916	76	18	filter	filter	NOUN
admet-916	76	19	mass	mass	NOUN
admet-916	76	20	was	be	AUX
admet-916	76	21	158.67	158.67	NUM
admet-916	76	22	±	±	NUM
admet-916	76	23	5.59	5.59	NUM
admet-916	76	24	%	%	NOUN
admet-916	76	25	.	.	PUNCT
admet-916	77	1	these	these	DET
admet-916	77	2	values	value	NOUN
admet-916	77	3	are	be	AUX
admet-916	77	4	similar	similar	ADJ
admet-916	77	5	to	to	ADP
admet-916	77	6	the	the	DET
admet-916	77	7	values	value	NOUN
admet-916	77	8	of	of	ADP
admet-916	77	9	experimental	experimental	ADJ
admet-916	77	10	studies	study	NOUN
admet-916	77	11	conducted	conduct	VERB
admet-916	77	12	by	by	ADP
admet-916	77	13	corti	corti	PROPN
admet-916	77	14	et	et	PROPN
admet-916	77	15	al	al	PROPN
admet-916	77	16	.	.	PUNCT
admet-916	78	1	[	[	X
admet-916	78	2	1	1	X
admet-916	78	3	]	]	PUNCT
admet-916	78	4	and	and	CCONJ
admet-916	78	5	our	our	PRON
admet-916	78	6	study	study	NOUN
admet-916	78	7	group	group	NOUN
admet-916	78	8	[	[	X
admet-916	78	9	16	16	NUM
admet-916	78	10	]	]	PUNCT
admet-916	78	11	.	.	PUNCT
admet-916	79	1	according	accord	VERB
admet-916	79	2	to	to	ADP
admet-916	79	3	both	both	DET
admet-916	79	4	studies	study	NOUN
admet-916	79	5	,	,	PUNCT
admet-916	79	6	the	the	DET
admet-916	79	7	structure	structure	NOUN
admet-916	79	8	of	of	ADP
admet-916	79	9	a	a	DET
admet-916	79	10	membrane	membrane	NOUN
admet-916	79	11	filter	filter	NOUN
admet-916	79	12	that	that	PRON
admet-916	79	13	was	be	AUX
admet-916	79	14	not	not	PART
admet-916	79	15	originally	originally	ADV
admet-916	79	16	intended	intend	VERB
admet-916	79	17	for	for	ADP
admet-916	79	18	use	use	NOUN
admet-916	79	19	in	in	ADP
admet-916	79	20	this	this	DET
admet-916	79	21	experiment	experiment	NOUN
admet-916	79	22	is	be	AUX
admet-916	79	23	responsible	responsible	ADJ
admet-916	79	24	for	for	ADP
admet-916	79	25	the	the	DET
admet-916	79	26	larger	large	ADJ
admet-916	79	27	increase	increase	NOUN
admet-916	79	28	in	in	ADP
admet-916	79	29	filter	filter	NOUN
admet-916	79	30	mass	mass	NOUN
admet-916	79	31	after	after	ADP
admet-916	79	32	impregnation	impregnation	NOUN
admet-916	79	33	.	.	PUNCT
admet-916	80	1	admet	admet	PROPN
admet-916	80	2	&	&	CCONJ
admet-916	80	3	dmpk	dmpk	PROPN
admet-916	80	4	9(1	9(1	NUM
admet-916	80	5	)	)	PUNCT
admet-916	80	6	(	(	PUNCT
admet-916	80	7	2021	2021	NUM
admet-916	80	8	)	)	PUNCT
admet-916	80	9	57	57	NUM
admet-916	80	10	-	-	SYM
admet-916	80	11	68	68	NUM
admet-916	80	12	passive	passive	ADJ
admet-916	80	13	transport	transport	NOUN
admet-916	80	14	of	of	ADP
admet-916	80	15	ketoprofen	ketoprofen	NOUN
admet-916	80	16	and	and	CCONJ
admet-916	80	17	metformin	metformin	PROPN
admet-916	80	18	doi	doi	PROPN
admet-916	80	19	:	:	PUNCT
admet-916	80	20	http://dx.doi.org/10.5599/admet.916	http://dx.doi.org/10.5599/admet.916	PROPN
admet-916	80	21	61	61	NUM
admet-916	80	22	permeation	permeation	NOUN
admet-916	80	23	of	of	ADP
admet-916	80	24	ketoprofen	ketoprofen	NOUN
admet-916	80	25	dependent	dependent	ADJ
admet-916	80	26	on	on	ADP
admet-916	80	27	the	the	DET
admet-916	80	28	ph	ph	NOUN
admet-916	80	29	of	of	ADP
admet-916	80	30	the	the	DET
admet-916	80	31	donor	donor	NOUN
admet-916	80	32	solution	solution	NOUN
admet-916	80	33	the	the	DET
admet-916	80	34	ketoprofen	ketoprofen	NOUN
admet-916	80	35	permeation	permeation	NOUN
admet-916	80	36	profiles	profile	NOUN
admet-916	80	37	'	'	PART
admet-916	80	38	parameters	parameter	NOUN
admet-916	80	39	at	at	ADP
admet-916	80	40	different	different	ADJ
admet-916	80	41	ph	ph	NOUN
admet-916	80	42	of	of	ADP
admet-916	80	43	the	the	DET
admet-916	80	44	donor	donor	NOUN
admet-916	80	45	compartment	compartment	NOUN
admet-916	80	46	are	be	AUX
admet-916	80	47	presented	present	VERB
admet-916	80	48	in	in	ADP
admet-916	80	49	table	table	NOUN
admet-916	80	50	1	1	NUM
admet-916	80	51	and	and	CCONJ
admet-916	80	52	figure	figure	VERB
admet-916	80	53	2	2	NUM
admet-916	80	54	.	.	PUNCT
admet-916	80	55	table	table	NOUN
admet-916	80	56	1	1	NUM
admet-916	80	57	.	.	PUNCT
admet-916	81	1	mean	mean	ADJ
admet-916	81	2	values	value	NOUN
admet-916	81	3	(	(	PUNCT
admet-916	81	4	n	n	NOUN
admet-916	81	5	=	=	SYM
admet-916	81	6	3	3	NUM
admet-916	81	7	)	)	PUNCT
admet-916	81	8	of	of	ADP
admet-916	81	9	the	the	DET
admet-916	81	10	apparent	apparent	ADJ
admet-916	81	11	permeation	permeation	NOUN
admet-916	81	12	coefficients	coefficient	NOUN
admet-916	81	13	(	(	PUNCT
admet-916	81	14	papp	papp	NOUN
admet-916	81	15	)	)	PUNCT
admet-916	81	16	of	of	ADP
admet-916	81	17	ketoprofen	ketoprofen	NOUN
admet-916	81	18	,	,	PUNCT
admet-916	81	19	the	the	DET
admet-916	81	20	recovery	recovery	NOUN
admet-916	81	21	of	of	ADP
admet-916	81	22	the	the	DET
admet-916	81	23	substance	substance	NOUN
admet-916	81	24	not	not	PART
admet-916	81	25	retained	retain	VERB
admet-916	81	26	by	by	ADP
admet-916	81	27	the	the	DET
admet-916	81	28	membrane	membrane	NOUN
admet-916	81	29	(	(	PUNCT
admet-916	81	30	r	r	NOUN
admet-916	81	31	)	)	PUNCT
admet-916	81	32	and	and	CCONJ
admet-916	81	33	percentage	percentage	NOUN
admet-916	81	34	of	of	ADP
admet-916	81	35	calculated	calculated	ADJ
admet-916	81	36	(	(	PUNCT
admet-916	81	37	non)ionized	non)ionized	ADJ
admet-916	81	38	species	specie	NOUN
admet-916	81	39	(	(	PUNCT
admet-916	81	40	ha	ha	INTJ
admet-916	81	41	/	/	SYM
admet-916	81	42	a	a	NOUN
admet-916	81	43	)	)	PUNCT
admet-916	81	44	at	at	ADP
admet-916	81	45	different	different	ADJ
admet-916	81	46	ph	ph	ADJ
admet-916	81	47	values	value	NOUN
admet-916	81	48	of	of	ADP
admet-916	81	49	donor	donor	NOUN
admet-916	81	50	compartment	compartment	NOUN
admet-916	81	51	.	.	PUNCT
admet-916	82	1	ph	ph	ADJ
admet-916	82	2	papp	papp	NOUN
admet-916	82	3	(	(	PUNCT
admet-916	82	4	×	×	PROPN
admet-916	82	5	10	10	NUM
admet-916	82	6	-5	-5	NOUN
admet-916	82	7	cm	cm	NOUN
admet-916	82	8	s	s	PART
admet-916	82	9	-1	-1	NOUN
admet-916	82	10	)	)	PUNCT
admet-916	82	11	±	±	PROPN
admet-916	82	12	sd	sd	ADP
admet-916	82	13	r(%	r(%	PROPN
admet-916	82	14	)	)	PUNCT
admet-916	82	15	±	±	PROPN
admet-916	82	16	sd	sd	ADP
admet-916	82	17	ha	ha	INTJ
admet-916	82	18	/	/	SYM
admet-916	82	19	a	a	DET
admet-916	82	20	(	(	PUNCT
admet-916	82	21	%	%	NOUN
admet-916	82	22	)	)	PUNCT
admet-916	82	23	7.4	7.4	NUM
admet-916	82	24	6.95	6.95	NUM
admet-916	82	25	±	±	NUM
admet-916	82	26	0.51	0.51	NUM
admet-916	82	27	97.95	97.95	NUM
admet-916	82	28	±	±	NUM
admet-916	82	29	2.42	2.42	NUM
admet-916	82	30	0.11	0.11	NUM
admet-916	82	31	/	/	SYM
admet-916	82	32	99.89	99.89	NUM
admet-916	82	33	6.8	6.8	NUM
admet-916	82	34	16.8	16.8	NUM
admet-916	82	35	±	±	NUM
admet-916	82	36	1.10	1.10	NUM
admet-916	82	37	87.83	87.83	NUM
admet-916	82	38	±	±	NUM
admet-916	82	39	2.77	2.77	NUM
admet-916	82	40	0.44	0.44	NUM
admet-916	82	41	/	/	SYM
admet-916	82	42	99.56	99.56	NUM
admet-916	82	43	4.5	4.5	NUM
admet-916	82	44	41.6	41.6	NUM
admet-916	82	45	±	±	NUM
admet-916	82	46	1.67	1.67	NUM
admet-916	82	47	83.52	83.52	NUM
admet-916	82	48	±	±	NUM
admet-916	82	49	1.68	1.68	NUM
admet-916	82	50	47.17	47.17	NUM
admet-916	82	51	/	/	SYM
admet-916	82	52	52.83	52.83	NUM
admet-916	82	53	3.0	3.0	NUM
admet-916	82	54	12.9	12.9	NUM
admet-916	82	55	±	±	NUM
admet-916	82	56	0.28	0.28	NUM
admet-916	82	57	51.91	51.91	NUM
admet-916	82	58	±	±	NUM
admet-916	82	59	1.79	1.79	NUM
admet-916	82	60	96.61	96.61	NUM
admet-916	82	61	/	/	SYM
admet-916	82	62	3.39	3.39	NUM
admet-916	82	63	figure	figure	NOUN
admet-916	82	64	2	2	NUM
admet-916	82	65	.	.	PUNCT
admet-916	82	66	overall	overall	ADJ
admet-916	82	67	permeated	permeate	VERB
admet-916	82	68	amount	amount	NOUN
admet-916	82	69	of	of	ADP
admet-916	82	70	ketoprofen	ketoprofen	NOUN
admet-916	82	71	through	through	ADP
admet-916	82	72	the	the	DET
admet-916	82	73	artificial	artificial	ADJ
admet-916	82	74	membrane	membrane	NOUN
admet-916	82	75	at	at	ADP
admet-916	82	76	different	different	ADJ
admet-916	82	77	ph	ph	ADJ
admet-916	82	78	values	value	NOUN
admet-916	82	79	of	of	ADP
admet-916	82	80	donor	donor	NOUN
admet-916	82	81	compartment	compartment	NOUN
admet-916	82	82	.	.	PUNCT
admet-916	83	1	large	large	ADJ
admet-916	83	2	values	value	NOUN
admet-916	83	3	of	of	ADP
admet-916	83	4	the	the	DET
admet-916	83	5	apparent	apparent	ADJ
admet-916	83	6	permeation	permeation	NOUN
admet-916	83	7	coefficients	coefficient	NOUN
admet-916	83	8	confirm	confirm	VERB
admet-916	83	9	that	that	SCONJ
admet-916	83	10	it	it	PRON
admet-916	83	11	is	be	AUX
admet-916	83	12	a	a	DET
admet-916	83	13	highly	highly	ADV
admet-916	83	14	permeable	permeable	ADJ
admet-916	83	15	substance	substance	NOUN
admet-916	83	16	.	.	PUNCT
admet-916	84	1	the	the	DET
admet-916	84	2	low	low	ADJ
admet-916	84	3	standard	standard	ADJ
admet-916	84	4	deviation	deviation	NOUN
admet-916	84	5	of	of	ADP
admet-916	84	6	the	the	DET
admet-916	84	7	apparent	apparent	ADJ
admet-916	84	8	permeation	permeation	NOUN
admet-916	84	9	coefficients	coefficient	NOUN
admet-916	84	10	shows	show	VERB
admet-916	84	11	good	good	ADJ
admet-916	84	12	reproducibility	reproducibility	NOUN
admet-916	84	13	of	of	ADP
admet-916	84	14	the	the	DET
admet-916	84	15	method	method	NOUN
admet-916	84	16	for	for	ADP
admet-916	84	17	highly	highly	ADV
admet-916	84	18	permeable	permeable	ADJ
admet-916	84	19	substances	substance	NOUN
admet-916	84	20	.	.	PUNCT
admet-916	85	1	the	the	DET
admet-916	85	2	recovery	recovery	NOUN
admet-916	85	3	values	value	NOUN
admet-916	85	4	indicate	indicate	VERB
admet-916	85	5	whether	whether	SCONJ
admet-916	85	6	ketoprofen	ketoprofen	NOUN
admet-916	85	7	was	be	AUX
admet-916	85	8	retained	retain	VERB
admet-916	85	9	in	in	ADP
admet-916	85	10	the	the	DET
admet-916	85	11	membrane	membrane	NOUN
admet-916	85	12	,	,	PUNCT
admet-916	85	13	and	and	CCONJ
admet-916	85	14	this	this	DET
admet-916	85	15	retention	retention	NOUN
admet-916	85	16	varied	vary	VERB
admet-916	85	17	significantly	significantly	ADV
admet-916	85	18	depending	depend	VERB
admet-916	85	19	on	on	ADP
admet-916	85	20	the	the	DET
admet-916	85	21	ph	ph	ADJ
admet-916	85	22	value	value	NOUN
admet-916	85	23	.	.	PUNCT
admet-916	86	1	in	in	ADP
admet-916	86	2	general	general	ADJ
admet-916	86	3	,	,	PUNCT
admet-916	86	4	ionized	ionized	ADJ
admet-916	86	5	substances	substance	NOUN
admet-916	86	6	are	be	AUX
admet-916	86	7	better	well	ADV
admet-916	86	8	soluble	soluble	ADJ
admet-916	86	9	,	,	PUNCT
admet-916	86	10	and	and	CCONJ
admet-916	86	11	non	non	ADJ
admet-916	86	12	-	-	ADJ
admet-916	86	13	ionized	ionized	ADJ
admet-916	86	14	ones	one	NOUN
admet-916	86	15	pass	pass	VERB
admet-916	86	16	through	through	ADP
admet-916	86	17	the	the	DET
admet-916	86	18	cell	cell	NOUN
admet-916	86	19	membrane	membrane	NOUN
admet-916	86	20	better	well	ADV
admet-916	86	21	.	.	PUNCT
admet-916	87	1	the	the	DET
admet-916	87	2	calculated	calculated	ADJ
admet-916	87	3	percentage	percentage	NOUN
admet-916	87	4	of	of	ADP
admet-916	87	5	non	non	ADJ
admet-916	87	6	-	-	ADJ
admet-916	87	7	ionized	ionized	ADJ
admet-916	87	8	ketoprofen	ketoprofen	NOUN
admet-916	87	9	decreased	decrease	VERB
admet-916	87	10	from	from	ADP
admet-916	87	11	96.61	96.61	NUM
admet-916	87	12	%	%	NOUN
admet-916	87	13	for	for	ADP
admet-916	87	14	ph	ph	NOUN
admet-916	87	15	=	=	SYM
admet-916	87	16	3.0	3.0	NUM
admet-916	87	17	to	to	PART
admet-916	87	18	0.11	0.11	NUM
admet-916	87	19	%	%	NOUN
admet-916	87	20	at	at	ADP
admet-916	87	21	ph	ph	NOUN
admet-916	87	22	=	=	SYM
admet-916	87	23	7.4	7.4	NUM
admet-916	87	24	(	(	PUNCT
admet-916	87	25	table	table	NOUN
admet-916	87	26	1	1	NUM
admet-916	87	27	)	)	PUNCT
admet-916	87	28	.	.	PUNCT
admet-916	88	1	ketoprofen	ketoprofen	VERB
admet-916	88	2	is	be	AUX
admet-916	88	3	a	a	DET
admet-916	88	4	weak	weak	ADJ
admet-916	88	5	acid	acid	NOUN
admet-916	88	6	and	and	CCONJ
admet-916	88	7	its	its	PRON
admet-916	88	8	maximum	maximum	ADJ
admet-916	88	9	permeation	permeation	NOUN
admet-916	88	10	is	be	AUX
admet-916	88	11	expected	expect	VERB
admet-916	88	12	in	in	ADP
admet-916	88	13	areas	area	NOUN
admet-916	88	14	where	where	SCONJ
admet-916	88	15	the	the	DET
admet-916	88	16	ph	ph	ADJ
admet-916	88	17	value	value	NOUN
admet-916	88	18	is	be	AUX
admet-916	88	19	close	close	ADJ
admet-916	88	20	to	to	ADP
admet-916	88	21	the	the	DET
admet-916	88	22	pka	pka	NOUN
admet-916	88	23	of	of	ADP
admet-916	88	24	the	the	DET
admet-916	88	25	substance	substance	NOUN
admet-916	88	26	,	,	PUNCT
admet-916	88	27	which	which	PRON
admet-916	88	28	in	in	ADP
admet-916	88	29	the	the	DET
admet-916	88	30	case	case	NOUN
admet-916	88	31	of	of	ADP
admet-916	88	32	ketoprofen	ketoprofen	NOUN
admet-916	88	33	is	be	AUX
admet-916	88	34	4.45	4.45	NUM
admet-916	88	35	,	,	PUNCT
admet-916	88	36	where	where	SCONJ
admet-916	88	37	there	there	PRON
admet-916	88	38	is	be	VERB
admet-916	88	39	47.17	47.17	NUM
admet-916	88	40	%	%	NOUN
admet-916	88	41	non	non	ADJ
admet-916	88	42	-	-	ADJ
admet-916	88	43	ionized	ionized	ADJ
admet-916	88	44	ketoprofen	ketoprofen	NOUN
admet-916	88	45	.	.	PUNCT
admet-916	89	1	these	these	PRON
admet-916	89	2	obtained	obtain	VERB
admet-916	89	3	calculated	calculate	VERB
admet-916	89	4	values	value	NOUN
admet-916	89	5	of	of	ADP
admet-916	89	6	the	the	DET
admet-916	89	7	proportions	proportion	NOUN
admet-916	89	8	of	of	ADP
admet-916	89	9	ionized	ionized	ADJ
admet-916	89	10	and	and	CCONJ
admet-916	89	11	nonionized	nonionized	ADJ
admet-916	89	12	species	specie	NOUN
admet-916	89	13	explain	explain	VERB
admet-916	89	14	the	the	DET
admet-916	89	15	values	value	NOUN
admet-916	89	16	of	of	ADP
admet-916	89	17	the	the	DET
admet-916	89	18	apparent	apparent	ADJ
admet-916	89	19	permeation	permeation	NOUN
admet-916	89	20	coefficients	coefficient	NOUN
admet-916	89	21	and	and	CCONJ
admet-916	89	22	recovery	recovery	NOUN
admet-916	89	23	factors	factor	NOUN
admet-916	89	24	at	at	ADP
admet-916	89	25	individual	individual	ADJ
admet-916	89	26	ph	ph	VERB
admet-916	89	27	,	,	PUNCT
admet-916	89	28	discussed	discuss	VERB
admet-916	89	29	below	below	ADV
admet-916	89	30	.	.	PUNCT
admet-916	90	1	it	it	PRON
admet-916	90	2	can	can	AUX
admet-916	90	3	be	be	AUX
admet-916	90	4	seen	see	VERB
admet-916	90	5	from	from	ADP
admet-916	90	6	figure	figure	NOUN
admet-916	90	7	2	2	NUM
admet-916	90	8	that	that	SCONJ
admet-916	90	9	the	the	DET
admet-916	90	10	equilibrium	equilibrium	NOUN
admet-916	90	11	permeation	permeation	NOUN
admet-916	90	12	concentrations	concentration	NOUN
admet-916	90	13	were	be	AUX
admet-916	90	14	not	not	PART
admet-916	90	15	established	establish	VERB
admet-916	90	16	at	at	ADP
admet-916	90	17	any	any	DET
admet-916	90	18	ph	ph	NOUN
admet-916	90	19	during	during	ADP
admet-916	90	20	the	the	DET
admet-916	90	21	120	120	NUM
admet-916	90	22	-	-	PUNCT
admet-916	90	23	minute	minute	NOUN
admet-916	90	24	test	test	NOUN
admet-916	90	25	period	period	NOUN
admet-916	90	26	.	.	PUNCT
admet-916	91	1	http://dx.doi.org/10.5599/admet.916	http://dx.doi.org/10.5599/admet.916	PROPN
admet-916	91	2	alisa	alisa	PROPN
admet-916	91	3	elezović	elezović	PROPN
admet-916	91	4	et	et	PROPN
admet-916	91	5	al	al	PROPN
admet-916	91	6	.	.	PROPN
admet-916	91	7	admet	admet	PROPN
admet-916	91	8	&	&	CCONJ
admet-916	91	9	dmpk	dmpk	PROPN
admet-916	91	10	9(1	9(1	NUM
admet-916	91	11	)	)	PUNCT
admet-916	91	12	(	(	PUNCT
admet-916	91	13	2021	2021	NUM
admet-916	91	14	)	)	PUNCT
admet-916	91	15	57	57	NUM
admet-916	91	16	-	-	SYM
admet-916	91	17	68	68	NUM
admet-916	91	18	62	62	NUM
admet-916	91	19	in	in	ADP
admet-916	91	20	general	general	ADJ
admet-916	91	21	the	the	DET
admet-916	91	22	values	value	NOUN
admet-916	91	23	of	of	ADP
admet-916	91	24	papp	papp	NOUN
admet-916	91	25	in	in	ADP
admet-916	91	26	all	all	DET
admet-916	91	27	ph	ph	ADJ
admet-916	91	28	media	medium	NOUN
admet-916	91	29	were	be	AUX
admet-916	91	30	high	high	ADJ
admet-916	91	31	(	(	PUNCT
admet-916	91	32	table	table	NOUN
admet-916	91	33	1	1	NUM
admet-916	91	34	)	)	PUNCT
admet-916	91	35	.	.	PUNCT
admet-916	92	1	such	such	ADJ
admet-916	92	2	results	result	NOUN
admet-916	92	3	indicate	indicate	VERB
admet-916	92	4	high	high	ADJ
admet-916	92	5	permeability	permeability	NOUN
admet-916	92	6	of	of	ADP
admet-916	92	7	ketoprofen	ketoprofen	NOUN
admet-916	92	8	,	,	PUNCT
admet-916	92	9	which	which	PRON
admet-916	92	10	is	be	AUX
admet-916	92	11	in	in	ADP
admet-916	92	12	line	line	NOUN
admet-916	92	13	with	with	ADP
admet-916	92	14	the	the	DET
admet-916	92	15	literature	literature	NOUN
admet-916	92	16	data	datum	NOUN
admet-916	92	17	showing	show	VERB
admet-916	92	18	that	that	DET
admet-916	92	19	ketoprofen	ketoprofen	NOUN
admet-916	92	20	belongs	belong	VERB
admet-916	92	21	to	to	ADP
admet-916	92	22	bcs	bcs	PROPN
admet-916	92	23	class	class	PROPN
admet-916	92	24	ii	ii	PROPN
admet-916	92	25	.	.	PUNCT
admet-916	93	1	the	the	DET
admet-916	93	2	recovery	recovery	NOUN
admet-916	93	3	value	value	NOUN
admet-916	93	4	increased	increase	VERB
admet-916	93	5	with	with	ADP
admet-916	93	6	increasing	increase	VERB
admet-916	93	7	ph	ph	NOUN
admet-916	93	8	(	(	PUNCT
admet-916	93	9	table	table	NOUN
admet-916	93	10	1	1	NUM
admet-916	93	11	)	)	PUNCT
admet-916	93	12	,	,	PUNCT
admet-916	93	13	and	and	CCONJ
admet-916	93	14	for	for	ADP
admet-916	93	15	ph	ph	NOUN
admet-916	93	16	=	=	SYM
admet-916	93	17	7.4	7.4	NUM
admet-916	93	18	the	the	DET
admet-916	93	19	recovery	recovery	NOUN
admet-916	93	20	value	value	NOUN
admet-916	93	21	was	be	AUX
admet-916	93	22	97.95	97.95	NUM
admet-916	93	23	%	%	NOUN
admet-916	93	24	.	.	PUNCT
admet-916	94	1	such	such	DET
admet-916	94	2	a	a	DET
admet-916	94	3	high	high	ADJ
admet-916	94	4	value	value	NOUN
admet-916	94	5	indicates	indicate	VERB
admet-916	94	6	that	that	SCONJ
admet-916	94	7	a	a	DET
admet-916	94	8	very	very	ADV
admet-916	94	9	small	small	ADJ
admet-916	94	10	percentage	percentage	NOUN
admet-916	94	11	of	of	ADP
admet-916	94	12	the	the	DET
admet-916	94	13	substance	substance	NOUN
admet-916	94	14	was	be	AUX
admet-916	94	15	retained	retain	VERB
admet-916	94	16	by	by	ADP
admet-916	94	17	the	the	DET
admet-916	94	18	membrane	membrane	NOUN
admet-916	94	19	.	.	PUNCT
admet-916	95	1	the	the	DET
admet-916	95	2	recovery	recovery	NOUN
admet-916	95	3	value	value	NOUN
admet-916	95	4	decreased	decrease	VERB
admet-916	95	5	with	with	ADP
admet-916	95	6	decreasing	decrease	VERB
admet-916	95	7	ph	ph	VERB
admet-916	95	8	,	,	PUNCT
admet-916	95	9	and	and	CCONJ
admet-916	95	10	the	the	DET
admet-916	95	11	lowest	low	ADJ
admet-916	95	12	percentage	percentage	NOUN
admet-916	95	13	of	of	ADP
admet-916	95	14	the	the	DET
admet-916	95	15	recovered	recovered	ADJ
admet-916	95	16	substance	substance	NOUN
admet-916	95	17	was	be	AUX
admet-916	95	18	measured	measure	VERB
admet-916	95	19	at	at	ADP
admet-916	95	20	ph	ph	NOUN
admet-916	95	21	=	=	SYM
admet-916	95	22	3	3	NUM
admet-916	96	1	and	and	CCONJ
admet-916	96	2	it	it	PRON
admet-916	96	3	was	be	AUX
admet-916	96	4	r	r	NOUN
admet-916	96	5	=	=	SYM
admet-916	96	6	51.93	51.93	NUM
admet-916	96	7	%	%	NOUN
admet-916	96	8	.	.	PUNCT
admet-916	97	1	in	in	ADP
admet-916	97	2	case	case	NOUN
admet-916	97	3	of	of	ADP
admet-916	97	4	weak	weak	ADJ
admet-916	97	5	acids	acid	NOUN
admet-916	97	6	,	,	PUNCT
admet-916	97	7	such	such	ADJ
admet-916	97	8	as	as	ADP
admet-916	97	9	ketoprofen	ketoprofen	NOUN
admet-916	97	10	,	,	PUNCT
admet-916	97	11	the	the	DET
admet-916	97	12	proportion	proportion	NOUN
admet-916	97	13	of	of	ADP
admet-916	97	14	non	non	ADJ
admet-916	97	15	-	-	ADJ
admet-916	97	16	ionized	ionized	ADJ
admet-916	97	17	substance	substance	NOUN
admet-916	97	18	is	be	AUX
admet-916	97	19	increased	increase	VERB
admet-916	97	20	at	at	ADP
admet-916	97	21	ph	ph	ADJ
admet-916	97	22	values	value	NOUN
admet-916	97	23	below	below	ADP
admet-916	97	24	pka	pka	PROPN
admet-916	97	25	,	,	PUNCT
admet-916	97	26	i.e.	i.e.	X
admet-916	97	27	ph	ph	NOUN
admet-916	97	28	of	of	ADP
admet-916	97	29	3.0	3.0	NUM
admet-916	97	30	in	in	ADP
admet-916	97	31	this	this	DET
admet-916	97	32	case	case	NOUN
admet-916	97	33	.	.	PUNCT
admet-916	98	1	the	the	DET
admet-916	98	2	increased	increase	VERB
admet-916	98	3	portion	portion	NOUN
admet-916	98	4	of	of	ADP
admet-916	98	5	non	non	ADJ
admet-916	98	6	-	-	ADJ
admet-916	98	7	ionized	ionized	ADJ
admet-916	98	8	substance	substance	NOUN
admet-916	98	9	makes	make	VERB
admet-916	98	10	this	this	DET
admet-916	98	11	substance	substance	NOUN
admet-916	98	12	more	more	ADV
admet-916	98	13	lipophilic	lipophilic	ADJ
admet-916	98	14	and	and	CCONJ
admet-916	98	15	thus	thus	ADV
admet-916	98	16	has	have	VERB
admet-916	98	17	a	a	DET
admet-916	98	18	higher	high	ADJ
admet-916	98	19	affinity	affinity	NOUN
admet-916	98	20	for	for	ADP
admet-916	98	21	the	the	DET
admet-916	98	22	lipophilic	lipophilic	ADJ
admet-916	98	23	membrane	membrane	NOUN
admet-916	98	24	.	.	PUNCT
admet-916	99	1	when	when	SCONJ
admet-916	99	2	analysing	analyse	VERB
admet-916	99	3	the	the	DET
admet-916	99	4	obtained	obtain	VERB
admet-916	99	5	values	value	NOUN
admet-916	99	6	of	of	ADP
admet-916	99	7	apparent	apparent	ADJ
admet-916	99	8	permeation	permeation	NOUN
admet-916	99	9	coefficients	coefficient	NOUN
admet-916	99	10	from	from	ADP
admet-916	99	11	table	table	NOUN
admet-916	99	12	1	1	NUM
admet-916	99	13	,	,	PUNCT
admet-916	99	14	it	it	PRON
admet-916	99	15	can	can	AUX
admet-916	99	16	be	be	AUX
admet-916	99	17	noticed	notice	VERB
admet-916	99	18	that	that	SCONJ
admet-916	99	19	unlike	unlike	ADP
admet-916	99	20	recovery	recovery	NOUN
admet-916	99	21	values	value	NOUN
admet-916	99	22	,	,	PUNCT
admet-916	99	23	papp	papp	NOUN
admet-916	99	24	did	do	AUX
admet-916	99	25	not	not	PART
admet-916	99	26	have	have	VERB
admet-916	99	27	a	a	DET
admet-916	99	28	linear	linear	ADJ
admet-916	99	29	growth	growth	NOUN
admet-916	99	30	with	with	ADP
admet-916	99	31	ph	ph	ADJ
admet-916	99	32	values	value	NOUN
admet-916	99	33	.	.	PUNCT
admet-916	100	1	the	the	DET
admet-916	100	2	lowest	low	ADJ
admet-916	100	3	mean	mean	ADJ
admet-916	100	4	value	value	NOUN
admet-916	100	5	of	of	ADP
admet-916	100	6	the	the	DET
admet-916	100	7	apparent	apparent	ADJ
admet-916	100	8	permeation	permeation	NOUN
admet-916	100	9	coefficient	coefficient	NOUN
admet-916	100	10	(	(	PUNCT
admet-916	100	11	papp	papp	NOUN
admet-916	100	12	=	=	SYM
admet-916	100	13	6.95	6.95	NUM
admet-916	100	14	±	±	NUM
admet-916	100	15	0.51	0.51	NUM
admet-916	100	16	×	×	NOUN
admet-916	100	17	10	10	NUM
admet-916	100	18	-5	-5	NOUN
admet-916	100	19	cm	cm	NOUN
admet-916	100	20	s	s	PART
admet-916	100	21	-1	-1	PUNCT
admet-916	100	22	)	)	PUNCT
admet-916	100	23	was	be	AUX
admet-916	100	24	at	at	ADP
admet-916	100	25	ph	ph	NOUN
admet-916	100	26	=	=	NOUN
admet-916	100	27	7.4	7.4	NUM
admet-916	100	28	.	.	PUNCT
admet-916	101	1	regardless	regardless	ADV
admet-916	101	2	of	of	ADP
admet-916	101	3	the	the	DET
admet-916	101	4	fact	fact	NOUN
admet-916	101	5	that	that	SCONJ
admet-916	101	6	the	the	DET
admet-916	101	7	recovery	recovery	NOUN
admet-916	101	8	value	value	NOUN
admet-916	101	9	at	at	ADP
admet-916	101	10	this	this	DET
admet-916	101	11	ph	ph	NOUN
admet-916	101	12	shows	show	VERB
admet-916	101	13	the	the	DET
admet-916	101	14	highest	high	ADJ
admet-916	101	15	percentage	percentage	NOUN
admet-916	101	16	,	,	PUNCT
admet-916	101	17	and	and	CCONJ
admet-916	101	18	papp	papp	NOUN
admet-916	101	19	is	be	AUX
admet-916	101	20	the	the	DET
admet-916	101	21	lowest	low	ADJ
admet-916	101	22	,	,	PUNCT
admet-916	101	23	such	such	ADJ
admet-916	101	24	results	result	NOUN
admet-916	101	25	are	be	AUX
admet-916	101	26	consistent	consistent	ADJ
admet-916	101	27	with	with	ADP
admet-916	101	28	the	the	DET
admet-916	101	29	results	result	NOUN
admet-916	101	30	obtained	obtain	VERB
admet-916	101	31	in	in	ADP
admet-916	101	32	the	the	DET
admet-916	101	33	original	original	ADJ
admet-916	101	34	method	method	NOUN
admet-916	101	35	.	.	PUNCT
admet-916	102	1	in	in	ADP
admet-916	102	2	the	the	DET
admet-916	102	3	original	original	ADJ
admet-916	102	4	papp	papp	NOUN
admet-916	102	5	method	method	NOUN
admet-916	102	6	,	,	PUNCT
admet-916	102	7	the	the	DET
admet-916	102	8	value	value	NOUN
admet-916	102	9	for	for	ADP
admet-916	102	10	ketoprofen	ketoprofen	NOUN
admet-916	102	11	at	at	ADP
admet-916	102	12	ph	ph	NOUN
admet-916	102	13	=	=	SYM
admet-916	102	14	7.4	7.4	NUM
admet-916	102	15	was	be	AUX
admet-916	102	16	4.27	4.27	NUM
admet-916	102	17	±	±	NUM
admet-916	102	18	0.08	0.08	NUM
admet-916	102	19	×	×	NOUN
admet-916	102	20	10	10	NUM
admet-916	102	21	-	-	SYM
admet-916	102	22	5	5	NUM
admet-916	102	23	cm	cm	NOUN
admet-916	102	24	s-1	s-1	NOUN
admet-916	102	25	and	and	CCONJ
admet-916	102	26	r	r	NOUN
admet-916	102	27	=	=	SYM
admet-916	102	28	99.1	99.1	NUM
admet-916	102	29	%	%	NOUN
admet-916	103	1	[	[	X
admet-916	103	2	15	15	NUM
admet-916	103	3	]	]	PUNCT
admet-916	103	4	.	.	PUNCT
admet-916	104	1	the	the	DET
admet-916	104	2	apparent	apparent	ADJ
admet-916	104	3	permeation	permeation	NOUN
admet-916	104	4	coefficient	coefficient	NOUN
admet-916	104	5	showed	show	VERB
admet-916	104	6	the	the	DET
admet-916	104	7	highest	high	ADJ
admet-916	104	8	values	value	NOUN
admet-916	104	9	at	at	ADP
admet-916	104	10	ph	ph	NOUN
admet-916	104	11	=	=	SYM
admet-916	104	12	4.5	4.5	NUM
admet-916	104	13	,	,	PUNCT
admet-916	104	14	which	which	PRON
admet-916	104	15	was	be	AUX
admet-916	104	16	to	to	PART
admet-916	104	17	be	be	AUX
admet-916	104	18	expected	expect	VERB
admet-916	104	19	given	give	VERB
admet-916	104	20	that	that	SCONJ
admet-916	104	21	the	the	DET
admet-916	104	22	maximum	maximum	ADJ
admet-916	104	23	permeation	permeation	NOUN
admet-916	104	24	of	of	ADP
admet-916	104	25	ketoprofen	ketoprofen	NOUN
admet-916	104	26	is	be	AUX
admet-916	104	27	expected	expect	VERB
admet-916	104	28	at	at	ADP
admet-916	104	29	ph	ph	ADJ
admet-916	104	30	values	value	NOUN
admet-916	104	31	that	that	PRON
admet-916	104	32	are	be	AUX
admet-916	104	33	closest	close	ADJ
admet-916	104	34	to	to	ADP
admet-916	104	35	the	the	DET
admet-916	104	36	pka	pka	PROPN
admet-916	104	37	value	value	NOUN
admet-916	104	38	of	of	ADP
admet-916	104	39	the	the	DET
admet-916	104	40	substance	substance	NOUN
admet-916	104	41	,	,	PUNCT
admet-916	104	42	which	which	PRON
admet-916	104	43	for	for	ADP
admet-916	104	44	ketoprofen	ketoprofen	NOUN
admet-916	104	45	has	have	VERB
admet-916	104	46	a	a	DET
admet-916	104	47	value	value	NOUN
admet-916	104	48	of	of	ADP
admet-916	104	49	4.45	4.45	NUM
admet-916	104	50	.	.	PUNCT
admet-916	105	1	this	this	PRON
admet-916	105	2	is	be	AUX
admet-916	105	3	due	due	ADJ
admet-916	105	4	to	to	ADP
admet-916	105	5	the	the	DET
admet-916	105	6	fact	fact	NOUN
admet-916	105	7	that	that	SCONJ
admet-916	105	8	at	at	ADP
admet-916	105	9	this	this	DET
admet-916	105	10	ph	ph	ADJ
admet-916	105	11	value	value	NOUN
admet-916	105	12	there	there	PRON
admet-916	105	13	is	be	VERB
admet-916	105	14	a	a	DET
admet-916	105	15	higher	high	ADJ
admet-916	105	16	ratio	ratio	NOUN
admet-916	105	17	of	of	ADP
admet-916	105	18	non	non	ADJ
admet-916	105	19	-	-	ADJ
admet-916	105	20	ionized	ionized	ADJ
admet-916	105	21	substance	substance	NOUN
admet-916	105	22	,	,	PUNCT
admet-916	105	23	which	which	PRON
admet-916	105	24	permeates	permeate	VERB
admet-916	105	25	,	,	PUNCT
admet-916	105	26	compared	compare	VERB
admet-916	105	27	to	to	ADP
admet-916	105	28	higher	high	ADJ
admet-916	105	29	ph	ph	ADJ
admet-916	105	30	values	value	NOUN
admet-916	105	31	,	,	PUNCT
admet-916	105	32	and	and	CCONJ
admet-916	105	33	,	,	PUNCT
admet-916	105	34	on	on	ADP
admet-916	105	35	the	the	DET
admet-916	105	36	other	other	ADJ
admet-916	105	37	hand	hand	NOUN
admet-916	105	38	,	,	PUNCT
admet-916	105	39	there	there	PRON
admet-916	105	40	is	be	VERB
admet-916	105	41	less	less	ADJ
admet-916	105	42	retention	retention	NOUN
admet-916	105	43	in	in	ADP
admet-916	105	44	the	the	DET
admet-916	105	45	membrane	membrane	NOUN
admet-916	105	46	compared	compare	VERB
admet-916	105	47	to	to	ADP
admet-916	105	48	lower	low	ADJ
admet-916	105	49	ph	ph	NOUN
admet-916	105	50	value	value	NOUN
admet-916	105	51	that	that	PRON
admet-916	105	52	is	be	AUX
admet-916	105	53	bellow	bellow	ADJ
admet-916	105	54	pka	pka	PROPN
admet-916	105	55	value	value	NOUN
admet-916	105	56	,	,	PUNCT
admet-916	105	57	probably	probably	ADV
admet-916	105	58	due	due	ADP
admet-916	105	59	to	to	ADP
admet-916	105	60	the	the	DET
admet-916	105	61	larger	large	ADJ
admet-916	105	62	portion	portion	NOUN
admet-916	105	63	of	of	ADP
admet-916	105	64	the	the	DET
admet-916	105	65	ionized	ionized	ADJ
admet-916	105	66	form	form	NOUN
admet-916	105	67	.	.	PUNCT
admet-916	106	1	the	the	DET
admet-916	106	2	apparent	apparent	ADJ
admet-916	106	3	permeation	permeation	NOUN
admet-916	106	4	coefficient	coefficient	NOUN
admet-916	106	5	was	be	AUX
admet-916	106	6	41.6±1.67	41.6±1.67	NUM
admet-916	106	7	×	×	NOUN
admet-916	106	8	10	10	NUM
admet-916	106	9	-	-	SYM
admet-916	106	10	5	5	NUM
admet-916	106	11	cm	cm	NUM
admet-916	106	12	s-1	s-1	NOUN
admet-916	106	13	.	.	PUNCT
admet-916	107	1	this	this	DET
admet-916	107	2	result	result	NOUN
admet-916	107	3	confirmed	confirm	VERB
admet-916	107	4	the	the	DET
admet-916	107	5	high	high	ADJ
admet-916	107	6	permeability	permeability	NOUN
admet-916	107	7	of	of	ADP
admet-916	107	8	ketoprofen	ketoprofen	NOUN
admet-916	107	9	,	,	PUNCT
admet-916	107	10	and	and	CCONJ
admet-916	107	11	is	be	AUX
admet-916	107	12	in	in	ADP
admet-916	107	13	line	line	NOUN
admet-916	107	14	with	with	ADP
admet-916	107	15	the	the	DET
admet-916	107	16	fact	fact	NOUN
admet-916	107	17	that	that	SCONJ
admet-916	107	18	ketoprofen	ketoprofen	NOUN
admet-916	107	19	is	be	AUX
admet-916	107	20	a	a	DET
admet-916	107	21	weak	weak	ADJ
admet-916	107	22	acid	acid	NOUN
admet-916	107	23	,	,	PUNCT
admet-916	107	24	the	the	DET
admet-916	107	25	absorption	absorption	NOUN
admet-916	107	26	of	of	ADP
admet-916	107	27	which	which	PRON
admet-916	107	28	is	be	AUX
admet-916	107	29	expected	expect	VERB
admet-916	107	30	at	at	ADP
admet-916	107	31	a	a	DET
admet-916	107	32	weakly	weakly	ADJ
admet-916	107	33	acidic	acidic	ADJ
admet-916	107	34	to	to	ADP
admet-916	107	35	neutral	neutral	ADJ
admet-916	107	36	ph	ph	ADJ
admet-916	107	37	values	value	NOUN
admet-916	107	38	.	.	PUNCT
admet-916	108	1	measurement	measurement	NOUN
admet-916	108	2	with	with	ADP
admet-916	108	3	phosphate	phosphate	ADJ
admet-916	108	4	buffer	buffer	NOUN
admet-916	108	5	in	in	ADP
admet-916	108	6	the	the	DET
admet-916	108	7	donor	donor	NOUN
admet-916	108	8	compartment	compartment	NOUN
admet-916	108	9	having	have	VERB
admet-916	108	10	a	a	DET
admet-916	108	11	ph	ph	NOUN
admet-916	108	12	of	of	ADP
admet-916	108	13	6.8	6.8	NUM
admet-916	108	14	resulted	result	VERB
admet-916	108	15	in	in	ADP
admet-916	108	16	a	a	DET
admet-916	108	17	papp	papp	NOUN
admet-916	108	18	value	value	NOUN
admet-916	108	19	of	of	ADP
admet-916	108	20	16.8±1.1	16.8±1.1	NUM
admet-916	108	21	×	×	NOUN
admet-916	108	22	10	10	NUM
admet-916	108	23	-5	-5	NOUN
admet-916	108	24	cm	cm	NOUN
admet-916	108	25	s	s	PART
admet-916	108	26	-1	-1	NOUN
admet-916	108	27	.	.	PUNCT
admet-916	109	1	these	these	DET
admet-916	109	2	values	value	NOUN
admet-916	109	3	correlate	correlate	VERB
admet-916	109	4	with	with	ADP
admet-916	109	5	all	all	DET
admet-916	109	6	the	the	DET
admet-916	109	7	above	above	ADJ
admet-916	109	8	facts	fact	NOUN
admet-916	109	9	related	relate	VERB
admet-916	109	10	to	to	ADP
admet-916	109	11	the	the	DET
admet-916	109	12	permeation	permeation	NOUN
admet-916	109	13	properties	property	NOUN
admet-916	109	14	of	of	ADP
admet-916	109	15	ketoprofen	ketoprofen	NOUN
admet-916	109	16	.	.	PUNCT
admet-916	110	1	at	at	ADP
admet-916	110	2	ph	ph	NOUN
admet-916	110	3	=	=	SYM
admet-916	110	4	3.0	3.0	NUM
admet-916	110	5	,	,	PUNCT
admet-916	110	6	the	the	DET
admet-916	110	7	mean	mean	ADJ
admet-916	110	8	papp	papp	NOUN
admet-916	110	9	value	value	NOUN
admet-916	110	10	obtained	obtain	VERB
admet-916	110	11	was	be	AUX
admet-916	110	12	12.9±0.28	12.9±0.28	NUM
admet-916	110	13	×	×	NOUN
admet-916	110	14	10	10	NUM
admet-916	110	15	-	-	SYM
admet-916	110	16	5	5	NUM
admet-916	110	17	cm	cm	NUM
admet-916	110	18	s-1	s-1	NOUN
admet-916	110	19	.	.	PUNCT
admet-916	111	1	these	these	DET
admet-916	111	2	results	result	NOUN
admet-916	111	3	were	be	AUX
admet-916	111	4	expected	expect	VERB
admet-916	111	5	,	,	PUNCT
admet-916	111	6	and	and	CCONJ
admet-916	111	7	it	it	PRON
admet-916	111	8	is	be	AUX
admet-916	111	9	assumed	assume	VERB
admet-916	111	10	that	that	SCONJ
admet-916	111	11	if	if	SCONJ
admet-916	111	12	there	there	PRON
admet-916	111	13	was	be	VERB
admet-916	111	14	no	no	DET
admet-916	111	15	increased	increased	ADJ
admet-916	111	16	affinity	affinity	NOUN
admet-916	111	17	of	of	ADP
admet-916	111	18	the	the	DET
admet-916	111	19	substance	substance	NOUN
admet-916	111	20	and	and	CCONJ
admet-916	111	21	the	the	DET
admet-916	111	22	membrane	membrane	NOUN
admet-916	111	23	,	,	PUNCT
admet-916	111	24	it	it	PRON
admet-916	111	25	would	would	AUX
admet-916	111	26	be	be	AUX
admet-916	111	27	even	even	ADV
admet-916	111	28	higher	high	ADJ
admet-916	111	29	at	at	ADP
admet-916	111	30	this	this	DET
admet-916	111	31	ph	ph	ADJ
admet-916	111	32	value	value	NOUN
admet-916	111	33	.	.	PUNCT
admet-916	112	1	table	table	NOUN
admet-916	112	2	2	2	NUM
admet-916	112	3	.	.	PUNCT
admet-916	112	4	experimentally	experimentally	ADV
admet-916	112	5	obtained	obtain	VERB
admet-916	112	6	apparent	apparent	ADJ
admet-916	112	7	permeation	permeation	NOUN
admet-916	112	8	coefficients	coefficient	NOUN
admet-916	112	9	of	of	ADP
admet-916	112	10	ketoprofen	ketoprofen	NOUN
admet-916	112	11	(	(	PUNCT
admet-916	112	12	cm	cm	NOUN
admet-916	112	13	s	s	PART
admet-916	112	14	-1	-1	PUNCT
admet-916	112	15	)	)	PUNCT
admet-916	112	16	at	at	ADP
admet-916	112	17	different	different	ADJ
admet-916	112	18	ph	ph	ADJ
admet-916	112	19	values	value	NOUN
admet-916	112	20	and	and	CCONJ
admet-916	112	21	literature	literature	NOUN
admet-916	112	22	data	datum	NOUN
admet-916	112	23	obtained	obtain	VERB
admet-916	112	24	by	by	ADP
admet-916	112	25	other	other	ADJ
admet-916	112	26	methods	method	NOUN
admet-916	112	27	.	.	PUNCT
admet-916	113	1	ph	ph	PROPN
admet-916	113	2	papp	papp	PROPN
admet-916	113	3	±	±	PROPN
admet-916	113	4	sd	sd	PROPN
admet-916	113	5	(	(	PUNCT
admet-916	113	6	×10	×10	NOUN
admet-916	113	7	-	-	SYM
admet-916	113	8	5	5	NUM
admet-916	113	9	)	)	PUNCT
admet-916	113	10	fa	fa	NOUN
admet-916	114	1	%	%	INTJ
admet-916	114	2	a	a	DET
admet-916	114	3	papp	papp	NOUN
admet-916	114	4	±	±	PROPN
admet-916	114	5	sd	sd	PROPN
admet-916	114	6	(	(	PUNCT
admet-916	114	7	×10	×10	NOUN
admet-916	114	8	-	-	SYM
admet-916	114	9	5)b	5)b	NUM
admet-916	114	10	papp	papp	NOUN
admet-916	114	11	±	±	PROPN
admet-916	114	12	sd	sd	PROPN
admet-916	114	13	(	(	PUNCT
admet-916	114	14	×10	×10	NOUN
admet-916	114	15	-	-	PUNCT
admet-916	114	16	5)c	5)c	PROPN
admet-916	114	17	peff	peff	PROPN
admet-916	114	18	±	±	PROPN
admet-916	114	19	sd	sd	PROPN
admet-916	114	20	(	(	PUNCT
admet-916	114	21	×10	×10	NOUN
admet-916	114	22	-	-	SYM
admet-916	114	23	5)d	5)d	NUM
admet-916	114	24	log	log	NOUN
admet-916	114	25	de	de	PROPN
admet-916	114	26	3.0	3.0	NUM
admet-916	114	27	12.9	12.9	NUM
admet-916	114	28	±	±	NUM
admet-916	114	29	0.28	0.28	NUM
admet-916	114	30	/	/	SYM
admet-916	114	31	/	/	SYM
admet-916	114	32	/	/	SYM
admet-916	114	33	/	/	SYM
admet-916	114	34	/	/	SYM
admet-916	114	35	4.5	4.5	NUM
admet-916	114	36	41.6	41.6	NUM
admet-916	114	37	±	±	NUM
admet-916	114	38	1.67	1.67	NUM
admet-916	114	39	99.9	99.9	NUM
admet-916	114	40	6.02	6.02	NUM
admet-916	114	41	±	±	NUM
admet-916	114	42	2.4	2.4	NUM
admet-916	114	43	*	*	PUNCT
admet-916	114	44	*	*	PUNCT
admet-916	114	45	/	/	PUNCT
admet-916	114	46	/	/	SYM
admet-916	114	47	1.8	1.8	NUM
admet-916	114	48	*	*	SYM
admet-916	114	49	*	*	SYM
admet-916	114	50	6.8	6.8	NUM
admet-916	114	51	16.8	16.8	NUM
admet-916	114	52	±	±	NUM
admet-916	114	53	1.1	1.1	NUM
admet-916	114	54	100	100	NUM
admet-916	114	55	1.86	1.86	NUM
admet-916	114	56	±	±	NUM
admet-916	114	57	1.5	1.5	NUM
admet-916	114	58	*	*	PUNCT
admet-916	114	59	*	*	PUNCT
admet-916	114	60	*	*	PROPN
admet-916	114	61	26.0	26.0	NUM
admet-916	114	62	±	±	NUM
admet-916	114	63	13.4	13.4	NUM
admet-916	114	64	*	*	PUNCT
admet-916	114	65	*	*	PUNCT
admet-916	114	66	*	*	PUNCT
admet-916	114	67	29.2	29.2	NUM
admet-916	114	68	±	±	NUM
admet-916	114	69	0.7	0.7	NUM
admet-916	114	70	*	*	PUNCT
admet-916	114	71	*	*	PUNCT
admet-916	114	72	*	*	PUNCT
admet-916	114	73	0.8	0.8	NUM
admet-916	114	74	7.4	7.4	NUM
admet-916	114	75	6.95	6.95	NUM
admet-916	114	76	±	±	NUM
admet-916	114	77	0.5	0.5	NUM
admet-916	114	78	100	100	NUM
admet-916	114	79	0.24	0.24	NUM
admet-916	114	80	±	±	NUM
admet-916	114	81	0.7	0.7	NUM
admet-916	114	82	15.8	15.8	NUM
admet-916	114	83	±	±	NUM
admet-916	114	84	.24	.24	NUM
admet-916	114	85	23.5±0.7	23.5±0.7	NUM
admet-916	114	86	0.1	0.1	NUM
admet-916	114	87	a	a	DET
admet-916	114	88	values	value	NOUN
admet-916	114	89	of	of	ADP
admet-916	114	90	simulated	simulated	ADJ
admet-916	114	91	fa	fa	PROPN
admet-916	114	92	(	(	PUNCT
admet-916	114	93	dose	dose	NOUN
admet-916	114	94	fraction	fraction	NOUN
admet-916	114	95	absorbed	absorb	VERB
admet-916	114	96	in	in	ADP
admet-916	114	97	humans	human	NOUN
admet-916	114	98	)	)	PUNCT
admet-916	115	1	[	[	X
admet-916	115	2	18	18	NUM
admet-916	115	3	]	]	X
admet-916	115	4	;	;	PUNCT
admet-916	115	5	b	b	X
admet-916	115	6	bml	bml	PROPN
admet-916	115	7	-	-	PUNCT
admet-916	115	8	pampa	pampa	PROPN
admet-916	115	9	(	(	PUNCT
admet-916	115	10	biomimetic	biomimetic	ADJ
admet-916	115	11	lipid	lipid	NOUN
admet-916	115	12	parallel	parallel	ADJ
admet-916	115	13	artificial	artificial	ADJ
admet-916	115	14	membrane	membrane	NOUN
admet-916	115	15	permeability	permeability	NOUN
admet-916	115	16	assay	assay	VERB
admet-916	115	17	)	)	PUNCT
admet-916	115	18	papp	papp	NOUN
admet-916	115	19	values	value	NOUN
admet-916	115	20	[	[	X
admet-916	115	21	19	19	NUM
admet-916	115	22	]	]	X
admet-916	115	23	;	;	PUNCT
admet-916	115	24	c	c	PROPN
admet-916	115	25	papp	papp	PROPN
admet-916	115	26	values	value	NOUN
admet-916	115	27	obtained	obtain	VERB
admet-916	115	28	by	by	ADP
admet-916	115	29	ussing	usse	VERB
admet-916	115	30	chambers	chamber	NOUN
admet-916	115	31	'	'	PART
admet-916	115	32	model	model	NOUN
admet-916	115	33	[	[	X
admet-916	115	34	20	20	NUM
admet-916	115	35	]	]	PUNCT
admet-916	115	36	;	;	PUNCT
admet-916	115	37	d	d	X
admet-916	115	38	spip	spip	PROPN
admet-916	115	39	peff	peff	PROPN
admet-916	115	40	(	(	PUNCT
admet-916	115	41	effective	effective	ADJ
admet-916	115	42	permeation	permeation	NOUN
admet-916	115	43	coefficient	coefficient	NOUN
admet-916	115	44	)	)	PUNCT
admet-916	115	45	values	value	NOUN
admet-916	116	1	[	[	X
admet-916	116	2	20	20	NUM
admet-916	116	3	]	]	PUNCT
admet-916	116	4	;	;	PUNCT
admet-916	116	5	e	e	X
admet-916	116	6	log	log	VERB
admet-916	116	7	d	d	PROPN
admet-916	116	8	(	(	PUNCT
admet-916	116	9	distribution	distribution	NOUN
admet-916	116	10	coefficient	coefficient	NOUN
admet-916	116	11	)	)	PUNCT
admet-916	116	12	values	value	NOUN
admet-916	116	13	[	[	X
admet-916	116	14	20,21	20,21	NUM
admet-916	116	15	]	]	PUNCT
admet-916	116	16	;	;	PUNCT
admet-916	116	17	*	*	PUNCT
admet-916	116	18	values	value	NOUN
admet-916	116	19	at	at	ADP
admet-916	116	20	ph	ph	NOUN
admet-916	116	21	=	=	SYM
admet-916	116	22	2	2	NUM
admet-916	116	23	;	;	PUNCT
admet-916	116	24	*	*	PUNCT
admet-916	117	1	*	*	NOUN
admet-916	117	2	values	value	NOUN
admet-916	117	3	at	at	ADP
admet-916	117	4	ph	ph	NOUN
admet-916	117	5	=	=	SYM
admet-916	117	6	5.5	5.5	NUM
admet-916	117	7	;	;	PUNCT
admet-916	118	1	*	*	PUNCT
admet-916	118	2	*	*	PUNCT
admet-916	119	1	*	*	NOUN
admet-916	119	2	values	value	NOUN
admet-916	119	3	at	at	ADP
admet-916	119	4	ph	ph	NOUN
admet-916	119	5	=	=	SYM
admet-916	119	6	6.5	6.5	NUM
admet-916	119	7	numerous	numerous	ADJ
admet-916	119	8	methods	method	NOUN
admet-916	119	9	for	for	ADP
admet-916	119	10	testing	test	VERB
admet-916	119	11	absorption	absorption	NOUN
admet-916	119	12	/	/	SYM
admet-916	119	13	permeation	permeation	NOUN
admet-916	119	14	have	have	AUX
admet-916	119	15	been	be	AUX
admet-916	119	16	described	describe	VERB
admet-916	119	17	in	in	ADP
admet-916	119	18	the	the	DET
admet-916	119	19	literature	literature	NOUN
admet-916	119	20	.	.	PUNCT
admet-916	120	1	table	table	NOUN
admet-916	120	2	2	2	NUM
admet-916	120	3	shows	show	VERB
admet-916	120	4	the	the	DET
admet-916	120	5	literature	literature	NOUN
admet-916	120	6	accounts	account	NOUN
admet-916	120	7	of	of	ADP
admet-916	120	8	experimentally	experimentally	ADV
admet-916	120	9	obtained	obtain	VERB
admet-916	120	10	values	value	NOUN
admet-916	120	11	of	of	ADP
admet-916	120	12	other	other	ADJ
admet-916	120	13	methods	method	NOUN
admet-916	120	14	for	for	ADP
admet-916	120	15	testing	test	VERB
admet-916	120	16	the	the	DET
admet-916	120	17	permeation	permeation	NOUN
admet-916	120	18	of	of	ADP
admet-916	120	19	ketoprofen	ketoprofen	NOUN
admet-916	120	20	at	at	ADP
admet-916	120	21	certain	certain	ADJ
admet-916	120	22	ph	ph	ADJ
admet-916	120	23	values	value	NOUN
admet-916	120	24	,	,	PUNCT
admet-916	120	25	as	as	ADV
admet-916	120	26	well	well	ADV
admet-916	120	27	as	as	ADP
admet-916	120	28	the	the	DET
admet-916	120	29	literature	literature	NOUN
admet-916	120	30	values	value	NOUN
admet-916	120	31	of	of	ADP
admet-916	120	32	the	the	DET
admet-916	120	33	in	in	ADP
admet-916	120	34	silico	silico	NOUN
admet-916	120	35	simulated	simulate	VERB
admet-916	120	36	dose	dose	NOUN
admet-916	120	37	fraction	fraction	NOUN
admet-916	120	38	absorbed	absorb	VERB
admet-916	120	39	in	in	ADP
admet-916	120	40	humans	human	NOUN
admet-916	120	41	(	(	PUNCT
admet-916	120	42	fa	fa	NOUN
admet-916	120	43	)	)	PUNCT
admet-916	120	44	,	,	PUNCT
admet-916	120	45	and	and	CCONJ
admet-916	120	46	log	log	VERB
admet-916	120	47	d.	d.	PROPN
admet-916	120	48	the	the	DET
admet-916	120	49	correlations	correlation	NOUN
admet-916	120	50	between	between	ADP
admet-916	120	51	the	the	DET
admet-916	120	52	obtained	obtain	VERB
admet-916	120	53	results	result	NOUN
admet-916	120	54	and	and	CCONJ
admet-916	120	55	these	these	DET
admet-916	120	56	admet	admet	PROPN
admet-916	120	57	&	&	CCONJ
admet-916	120	58	dmpk	dmpk	PROPN
admet-916	120	59	9(1	9(1	NUM
admet-916	120	60	)	)	PUNCT
admet-916	120	61	(	(	PUNCT
admet-916	120	62	2021	2021	NUM
admet-916	120	63	)	)	PUNCT
admet-916	120	64	57	57	NUM
admet-916	120	65	-	-	SYM
admet-916	120	66	68	68	NUM
admet-916	120	67	passive	passive	ADJ
admet-916	120	68	transport	transport	NOUN
admet-916	120	69	of	of	ADP
admet-916	120	70	ketoprofen	ketoprofen	NOUN
admet-916	120	71	and	and	CCONJ
admet-916	120	72	metformin	metformin	PROPN
admet-916	120	73	doi	doi	PROPN
admet-916	120	74	:	:	PUNCT
admet-916	120	75	http://dx.doi.org/10.5599/admet.916	http://dx.doi.org/10.5599/admet.916	PROPN
admet-916	120	76	63	63	NUM
admet-916	120	77	literature	literature	NOUN
admet-916	120	78	data	datum	NOUN
admet-916	120	79	were	be	AUX
admet-916	120	80	examined	examine	VERB
admet-916	120	81	.	.	PUNCT
admet-916	121	1	in	in	ADP
admet-916	121	2	general	general	ADJ
admet-916	121	3	,	,	PUNCT
admet-916	121	4	this	this	DET
admet-916	121	5	type	type	NOUN
admet-916	121	6	of	of	ADP
admet-916	121	7	testing	testing	NOUN
admet-916	121	8	referring	refer	VERB
admet-916	121	9	to	to	ADP
admet-916	121	10	ph	ph	ADJ
admet-916	121	11	dependence	dependence	NOUN
admet-916	121	12	is	be	AUX
admet-916	121	13	scarce	scarce	ADJ
admet-916	121	14	and	and	CCONJ
admet-916	121	15	lacking	lacking	ADJ
admet-916	121	16	.	.	PUNCT
admet-916	122	1	due	due	ADP
admet-916	122	2	to	to	ADP
admet-916	122	3	the	the	DET
admet-916	122	4	lack	lack	NOUN
admet-916	122	5	of	of	ADP
admet-916	122	6	experimental	experimental	ADJ
admet-916	122	7	data	datum	NOUN
admet-916	122	8	on	on	ADP
admet-916	122	9	the	the	DET
admet-916	122	10	permeation	permeation	NOUN
admet-916	122	11	coefficients	coefficient	NOUN
admet-916	122	12	of	of	ADP
admet-916	122	13	ketoprofen	ketoprofen	NOUN
admet-916	122	14	at	at	ADP
admet-916	122	15	the	the	DET
admet-916	122	16	exact	exact	ADJ
admet-916	122	17	same	same	ADJ
admet-916	122	18	ph	ph	ADJ
admet-916	122	19	values	value	NOUN
admet-916	122	20	,	,	PUNCT
admet-916	122	21	the	the	DET
admet-916	122	22	values	value	NOUN
admet-916	122	23	at	at	ADP
admet-916	122	24	approximate	approximate	ADJ
admet-916	122	25	ph	ph	NOUN
admet-916	122	26	were	be	AUX
admet-916	122	27	taken	take	VERB
admet-916	122	28	for	for	ADP
admet-916	122	29	certain	certain	ADJ
admet-916	122	30	parameters	parameter	NOUN
admet-916	122	31	,	,	PUNCT
admet-916	122	32	as	as	SCONJ
admet-916	122	33	indicated	indicate	VERB
admet-916	122	34	in	in	ADP
admet-916	122	35	the	the	DET
admet-916	122	36	legend	legend	NOUN
admet-916	122	37	of	of	ADP
admet-916	122	38	table	table	NOUN
admet-916	122	39	2	2	NUM
admet-916	122	40	.	.	PUNCT
admet-916	122	41	dose	dose	NOUN
admet-916	122	42	fraction	fraction	NOUN
admet-916	122	43	absorbed	absorb	VERB
admet-916	122	44	in	in	ADP
admet-916	122	45	humans	human	NOUN
admet-916	122	46	of	of	ADP
admet-916	122	47	ketoprofen	ketoprofen	NOUN
admet-916	122	48	is	be	AUX
admet-916	122	49	90	90	NUM
admet-916	122	50	%	%	NOUN
admet-916	122	51	,	,	PUNCT
admet-916	122	52	and	and	CCONJ
admet-916	122	53	it	it	PRON
admet-916	122	54	is	be	AUX
admet-916	122	55	mainly	mainly	ADV
admet-916	122	56	absorbed	absorb	VERB
admet-916	122	57	in	in	ADP
admet-916	122	58	the	the	DET
admet-916	122	59	small	small	ADJ
admet-916	122	60	intestine	intestine	NOUN
admet-916	123	1	[	[	X
admet-916	123	2	5	5	NUM
admet-916	123	3	]	]	PUNCT
admet-916	123	4	.	.	PUNCT
admet-916	124	1	however	however	ADV
admet-916	124	2	,	,	PUNCT
admet-916	124	3	due	due	ADP
admet-916	124	4	to	to	ADP
admet-916	124	5	the	the	DET
admet-916	124	6	lack	lack	NOUN
admet-916	124	7	of	of	ADP
admet-916	124	8	ph	ph	ADJ
admet-916	124	9	dependent	dependent	ADJ
admet-916	124	10	data	datum	NOUN
admet-916	124	11	on	on	ADP
admet-916	124	12	its	its	PRON
admet-916	124	13	in	in	ADP
admet-916	124	14	vivo	vivo	NOUN
admet-916	124	15	absorption	absorption	NOUN
admet-916	124	16	,	,	PUNCT
admet-916	124	17	the	the	DET
admet-916	124	18	obtained	obtain	VERB
admet-916	124	19	results	result	NOUN
admet-916	124	20	can	can	AUX
admet-916	124	21	not	not	PART
admet-916	124	22	be	be	AUX
admet-916	124	23	compared	compare	VERB
admet-916	124	24	or	or	CCONJ
admet-916	124	25	correlated	correlate	VERB
admet-916	124	26	.	.	PUNCT
admet-916	125	1	the	the	DET
admet-916	125	2	results	result	NOUN
admet-916	125	3	were	be	AUX
admet-916	125	4	compared	compare	VERB
admet-916	125	5	with	with	ADP
admet-916	125	6	the	the	DET
admet-916	125	7	available	available	ADJ
admet-916	125	8	results	result	NOUN
admet-916	125	9	of	of	ADP
admet-916	125	10	in	in	ADP
admet-916	125	11	silico	silico	NOUN
admet-916	125	12	simulated	simulate	VERB
admet-916	125	13	fraction	fraction	NOUN
admet-916	125	14	of	of	ADP
admet-916	125	15	the	the	DET
admet-916	125	16	dose	dose	NOUN
admet-916	125	17	absorbed	absorb	VERB
admet-916	125	18	in	in	ADP
admet-916	125	19	humans	human	NOUN
admet-916	125	20	at	at	ADP
admet-916	125	21	different	different	ADJ
admet-916	125	22	ph	ph	ADJ
admet-916	125	23	values	value	NOUN
admet-916	125	24	and	and	CCONJ
admet-916	125	25	gave	give	VERB
admet-916	125	26	the	the	DET
admet-916	125	27	correlation	correlation	NOUN
admet-916	125	28	factor	factor	NOUN
admet-916	125	29	of	of	ADP
admet-916	125	30	r2	r2	PROPN
admet-916	125	31	=	=	SYM
admet-916	125	32	0.9239	0.9239	NUM
admet-916	125	33	.	.	PUNCT
admet-916	126	1	the	the	DET
admet-916	126	2	comparisons	comparison	NOUN
admet-916	126	3	of	of	ADP
admet-916	126	4	the	the	DET
admet-916	126	5	results	result	NOUN
admet-916	126	6	of	of	ADP
admet-916	126	7	in	in	ADP
admet-916	126	8	situ	situ	NOUN
admet-916	126	9	and	and	CCONJ
admet-916	126	10	ex	ex	PRON
admet-916	126	11	vivo	vivo	NOUN
admet-916	126	12	models	model	NOUN
admet-916	126	13	[	[	X
admet-916	126	14	20	20	NUM
admet-916	126	15	]	]	PUNCT
admet-916	126	16	were	be	AUX
admet-916	126	17	possible	possible	ADJ
admet-916	126	18	only	only	ADV
admet-916	126	19	at	at	ADP
admet-916	126	20	two	two	NUM
admet-916	126	21	ph	ph	ADJ
admet-916	126	22	values	value	NOUN
admet-916	126	23	,	,	PUNCT
admet-916	126	24	namely	namely	ADV
admet-916	126	25	ph	ph	VERB
admet-916	126	26	=	=	SYM
admet-916	126	27	6.8	6.8	NUM
admet-916	126	28	and	and	CCONJ
admet-916	126	29	ph	ph	ADJ
admet-916	126	30	=	=	SYM
admet-916	126	31	7.4	7.4	NUM
admet-916	126	32	,	,	PUNCT
admet-916	126	33	so	so	SCONJ
admet-916	126	34	it	it	PRON
admet-916	126	35	was	be	AUX
admet-916	126	36	not	not	PART
admet-916	126	37	purposeful	purposeful	ADJ
admet-916	126	38	to	to	PART
admet-916	126	39	calculate	calculate	VERB
admet-916	126	40	the	the	DET
admet-916	126	41	correlation	correlation	NOUN
admet-916	126	42	coefficient	coefficient	NOUN
admet-916	126	43	.	.	PUNCT
admet-916	127	1	however	however	ADV
admet-916	127	2	,	,	PUNCT
admet-916	127	3	the	the	DET
admet-916	127	4	trend	trend	NOUN
admet-916	127	5	of	of	ADP
admet-916	127	6	increasing	increase	VERB
admet-916	127	7	permeation	permeation	NOUN
admet-916	127	8	with	with	ADP
admet-916	127	9	decreasing	decrease	VERB
admet-916	127	10	ph	ph	NOUN
admet-916	127	11	of	of	ADP
admet-916	127	12	the	the	DET
admet-916	127	13	environment	environment	NOUN
admet-916	127	14	in	in	ADP
admet-916	127	15	both	both	DET
admet-916	127	16	cases	case	NOUN
admet-916	127	17	was	be	AUX
admet-916	127	18	evident	evident	ADJ
admet-916	127	19	(	(	PUNCT
admet-916	127	20	table	table	NOUN
admet-916	127	21	2	2	NUM
admet-916	127	22	)	)	PUNCT
admet-916	127	23	.	.	PUNCT
admet-916	128	1	the	the	DET
admet-916	128	2	same	same	ADJ
admet-916	128	3	trend	trend	NOUN
admet-916	128	4	was	be	AUX
admet-916	128	5	present	present	ADJ
admet-916	128	6	for	for	ADP
admet-916	128	7	the	the	DET
admet-916	128	8	bml	bml	PROPN
admet-916	128	9	-	-	PUNCT
admet-916	128	10	pampa	pampa	NOUN
admet-916	128	11	assay	assay	NOUN
admet-916	128	12	and	and	CCONJ
admet-916	128	13	log	log	VERB
admet-916	128	14	d	d	NOUN
admet-916	128	15	results	result	NOUN
admet-916	128	16	,	,	PUNCT
admet-916	128	17	even	even	ADV
admet-916	128	18	taking	take	VERB
admet-916	128	19	into	into	ADP
admet-916	128	20	consideration	consideration	NOUN
admet-916	128	21	that	that	SCONJ
admet-916	128	22	the	the	DET
admet-916	128	23	ph	ph	NOUN
admet-916	128	24	was	be	AUX
admet-916	128	25	different	different	ADJ
admet-916	128	26	near	near	ADP
admet-916	128	27	pka	pka	PROPN
admet-916	128	28	of	of	ADP
admet-916	128	29	ketoprofen	ketoprofen	NOUN
admet-916	128	30	in	in	ADP
admet-916	128	31	the	the	DET
admet-916	128	32	two	two	NUM
admet-916	128	33	experiments	experiment	NOUN
admet-916	128	34	.	.	PUNCT
admet-916	129	1	comparison	comparison	NOUN
admet-916	129	2	of	of	ADP
admet-916	129	3	the	the	DET
admet-916	129	4	obtained	obtain	VERB
admet-916	129	5	results	result	NOUN
admet-916	129	6	with	with	ADP
admet-916	129	7	the	the	DET
admet-916	129	8	results	result	NOUN
admet-916	129	9	of	of	ADP
admet-916	129	10	corti	corti	PROPN
admet-916	129	11	et	et	PROPN
admet-916	129	12	al	al	PROPN
admet-916	129	13	.	.	PUNCT
admet-916	130	1	[	[	X
admet-916	130	2	15	15	NUM
admet-916	130	3	]	]	PUNCT
admet-916	130	4	and	and	CCONJ
admet-916	130	5	our	our	PRON
admet-916	130	6	earlier	early	ADJ
admet-916	130	7	results	result	NOUN
admet-916	130	8	[	[	X
admet-916	130	9	16	16	NUM
admet-916	130	10	]	]	PUNCT
admet-916	130	11	was	be	AUX
admet-916	130	12	not	not	PART
admet-916	130	13	possible	possible	ADJ
admet-916	130	14	due	due	ADP
admet-916	130	15	to	to	ADP
admet-916	130	16	the	the	DET
admet-916	130	17	lack	lack	NOUN
admet-916	130	18	of	of	ADP
admet-916	130	19	data	datum	NOUN
admet-916	130	20	on	on	ADP
admet-916	130	21	apparent	apparent	ADJ
admet-916	130	22	permeation	permeation	NOUN
admet-916	130	23	coefficients	coefficient	NOUN
admet-916	130	24	for	for	ADP
admet-916	130	25	all	all	DET
admet-916	130	26	ph	ph	ADJ
admet-916	130	27	values	value	NOUN
admet-916	130	28	.	.	PUNCT
admet-916	131	1	permeation	permeation	NOUN
admet-916	131	2	of	of	ADP
admet-916	131	3	metformin	metformin	PROPN
admet-916	131	4	dependent	dependent	ADJ
admet-916	131	5	on	on	ADP
admet-916	131	6	the	the	DET
admet-916	131	7	ph	ph	NOUN
admet-916	131	8	of	of	ADP
admet-916	131	9	the	the	DET
admet-916	131	10	donor	donor	NOUN
admet-916	131	11	solution	solution	NOUN
admet-916	131	12	the	the	DET
admet-916	131	13	metformin	metformin	PROPN
admet-916	131	14	permeation	permeation	NOUN
admet-916	131	15	profiles	profile	NOUN
admet-916	131	16	'	'	PART
admet-916	131	17	parameters	parameter	NOUN
admet-916	131	18	at	at	ADP
admet-916	131	19	different	different	ADJ
admet-916	131	20	ph	ph	NOUN
admet-916	131	21	of	of	ADP
admet-916	131	22	the	the	DET
admet-916	131	23	donor	donor	NOUN
admet-916	131	24	compartment	compartment	NOUN
admet-916	131	25	are	be	AUX
admet-916	131	26	presented	present	VERB
admet-916	131	27	in	in	ADP
admet-916	131	28	table	table	NOUN
admet-916	131	29	3	3	NUM
admet-916	131	30	and	and	CCONJ
admet-916	131	31	figure	figure	VERB
admet-916	131	32	3	3	NUM
admet-916	131	33	.	.	PUNCT
admet-916	132	1	the	the	DET
admet-916	132	2	pka	pka	PROPN
admet-916	132	3	value	value	NOUN
admet-916	132	4	of	of	ADP
admet-916	132	5	11.5	11.5	NUM
admet-916	132	6	makes	make	VERB
admet-916	132	7	metformin	metformin	NOUN
admet-916	132	8	a	a	DET
admet-916	132	9	strong	strong	ADJ
admet-916	132	10	base	base	NOUN
admet-916	132	11	found	find	VERB
admet-916	132	12	in	in	ADP
admet-916	132	13	non	non	ADJ
admet-916	132	14	-	-	ADJ
admet-916	132	15	ionized	ionized	ADJ
admet-916	132	16	form	form	NOUN
admet-916	132	17	in	in	ADP
admet-916	132	18	the	the	DET
admet-916	132	19	percentage	percentage	NOUN
admet-916	132	20	of	of	ADP
admet-916	132	21	only	only	ADV
admet-916	132	22	0.008	0.008	NUM
admet-916	132	23	%	%	NOUN
admet-916	132	24	at	at	ADP
admet-916	132	25	ph	ph	PROPN
admet-916	132	26	7.4	7.4	NUM
admet-916	132	27	.	.	PUNCT
admet-916	133	1	given	give	VERB
admet-916	133	2	the	the	DET
admet-916	133	3	physicochemical	physicochemical	ADJ
admet-916	133	4	properties	property	NOUN
admet-916	133	5	of	of	ADP
admet-916	133	6	metformin	metformin	NOUN
admet-916	133	7	(	(	PUNCT
admet-916	133	8	pka	pka	PROPN
admet-916	133	9	values	value	NOUN
admet-916	133	10	,	,	PUNCT
admet-916	133	11	log	log	VERB
admet-916	133	12	p	p	X
admet-916	133	13	)	)	PUNCT
admet-916	133	14	that	that	PRON
admet-916	133	15	determine	determine	VERB
admet-916	133	16	its	its	PRON
admet-916	133	17	high	high	ADJ
admet-916	133	18	solubility	solubility	NOUN
admet-916	133	19	and	and	CCONJ
admet-916	133	20	poor	poor	ADJ
admet-916	133	21	permeability	permeability	NOUN
admet-916	133	22	,	,	PUNCT
admet-916	133	23	metformin	metformin	NOUN
admet-916	133	24	will	will	AUX
admet-916	133	25	prevail	prevail	VERB
admet-916	133	26	at	at	ADP
admet-916	133	27	physiological	physiological	ADJ
admet-916	133	28	ph	ph	NOUN
admet-916	133	29	in	in	ADP
admet-916	133	30	ionized	ionized	ADJ
admet-916	133	31	form	form	NOUN
admet-916	133	32	,	,	PUNCT
admet-916	133	33	which	which	PRON
admet-916	133	34	will	will	AUX
admet-916	133	35	favor	favor	VERB
admet-916	133	36	its	its	PRON
admet-916	133	37	solubility	solubility	NOUN
admet-916	133	38	,	,	PUNCT
admet-916	133	39	but	but	CCONJ
admet-916	133	40	will	will	AUX
admet-916	133	41	not	not	PART
admet-916	133	42	favor	favor	VERB
admet-916	133	43	passive	passive	ADJ
admet-916	133	44	transport	transport	NOUN
admet-916	133	45	.	.	PUNCT
admet-916	134	1	due	due	ADP
admet-916	134	2	to	to	ADP
admet-916	134	3	its	its	PRON
admet-916	134	4	properties	property	NOUN
admet-916	134	5	,	,	PUNCT
admet-916	134	6	metformin	metformin	NOUN
admet-916	134	7	is	be	AUX
admet-916	134	8	mainly	mainly	ADV
admet-916	134	9	absorbed	absorb	VERB
admet-916	134	10	in	in	ADP
admet-916	134	11	vivo	vivo	NOUN
admet-916	134	12	by	by	ADP
admet-916	134	13	active	active	ADJ
admet-916	134	14	transport	transport	NOUN
admet-916	134	15	via	via	ADP
admet-916	134	16	number	number	NOUN
admet-916	134	17	of	of	ADP
admet-916	134	18	transporters	transporter	NOUN
admet-916	134	19	located	locate	VERB
admet-916	134	20	in	in	ADP
admet-916	134	21	intestinal	intestinal	ADJ
admet-916	134	22	membranes	membrane	NOUN
admet-916	134	23	[	[	X
admet-916	134	24	22	22	NUM
admet-916	134	25	]	]	PUNCT
admet-916	134	26	.	.	PUNCT
admet-916	135	1	otherwise	otherwise	ADV
admet-916	135	2	,	,	PUNCT
admet-916	135	3	for	for	ADP
admet-916	135	4	drugs	drug	NOUN
admet-916	135	5	belonging	belong	VERB
admet-916	135	6	to	to	ADP
admet-916	135	7	bcs	bcs	NOUN
admet-916	135	8	class	class	PROPN
admet-916	135	9	iii	iii	PROPN
admet-916	135	10	,	,	PUNCT
admet-916	135	11	it	it	PRON
admet-916	135	12	would	would	AUX
admet-916	135	13	be	be	AUX
admet-916	135	14	possible	possible	ADJ
admet-916	135	15	to	to	PART
admet-916	135	16	establish	establish	VERB
admet-916	135	17	an	an	DET
admet-916	135	18	in	in	ADP
admet-916	135	19	vivo	vivo	NOUN
admet-916	135	20	in	in	ADP
admet-916	135	21	vitro	vitro	X
admet-916	135	22	correlation	correlation	NOUN
admet-916	135	23	if	if	SCONJ
admet-916	135	24	the	the	DET
admet-916	135	25	drug	drug	NOUN
admet-916	135	26	is	be	AUX
admet-916	135	27	highly	highly	ADV
admet-916	135	28	soluble	soluble	ADJ
admet-916	135	29	(	(	PUNCT
admet-916	135	30	such	such	ADJ
admet-916	135	31	as	as	ADP
admet-916	135	32	metformin	metformin	NOUN
admet-916	135	33	)	)	PUNCT
admet-916	135	34	,	,	PUNCT
admet-916	135	35	if	if	SCONJ
admet-916	135	36	it	it	PRON
admet-916	135	37	is	be	AUX
admet-916	135	38	not	not	PART
admet-916	135	39	subject	subject	ADJ
admet-916	135	40	to	to	ADP
admet-916	135	41	the	the	DET
admet-916	135	42	first	first	ADJ
admet-916	135	43	pass	pass	NOUN
admet-916	135	44	effect	effect	NOUN
admet-916	135	45	and	and	CCONJ
admet-916	135	46	is	be	AUX
admet-916	135	47	not	not	PART
admet-916	135	48	metabolized	metabolize	VERB
admet-916	135	49	(	(	PUNCT
admet-916	135	50	such	such	ADJ
admet-916	135	51	as	as	ADP
admet-916	135	52	metformin	metformin	NOUN
admet-916	135	53	)	)	PUNCT
admet-916	135	54	and	and	CCONJ
admet-916	135	55	if	if	SCONJ
admet-916	135	56	it	it	PRON
admet-916	135	57	is	be	AUX
admet-916	135	58	not	not	PART
admet-916	135	59	transported	transport	VERB
admet-916	135	60	by	by	ADP
admet-916	135	61	carriers	carrier	NOUN
admet-916	135	62	.	.	PUNCT
admet-916	136	1	since	since	SCONJ
admet-916	136	2	it	it	PRON
admet-916	136	3	does	do	AUX
admet-916	136	4	not	not	PART
admet-916	136	5	meet	meet	VERB
admet-916	136	6	the	the	DET
admet-916	136	7	third	third	ADJ
admet-916	136	8	criterion	criterion	NOUN
admet-916	136	9	,	,	PUNCT
admet-916	136	10	it	it	PRON
admet-916	136	11	is	be	AUX
admet-916	136	12	not	not	PART
admet-916	136	13	possible	possible	ADJ
admet-916	136	14	to	to	PART
admet-916	136	15	establish	establish	VERB
admet-916	136	16	an	an	DET
admet-916	136	17	in	in	ADP
admet-916	136	18	vitro	vitro	X
admet-916	136	19	in	in	ADP
admet-916	136	20	vivo	vivo	ADJ
admet-916	136	21	correlation	correlation	NOUN
admet-916	136	22	for	for	ADP
admet-916	136	23	metformin	metformin	NOUN
admet-916	136	24	,	,	PUNCT
admet-916	136	25	but	but	CCONJ
admet-916	136	26	it	it	PRON
admet-916	136	27	is	be	AUX
admet-916	136	28	possible	possible	ADJ
admet-916	136	29	to	to	PART
admet-916	136	30	examine	examine	VERB
admet-916	136	31	the	the	DET
admet-916	136	32	extent	extent	NOUN
admet-916	136	33	to	to	PART
admet-916	136	34	which	which	PRON
admet-916	136	35	passive	passive	ADJ
admet-916	136	36	transport	transport	NOUN
admet-916	136	37	is	be	AUX
admet-916	136	38	involved	involve	VERB
admet-916	136	39	in	in	ADP
admet-916	136	40	its	its	PRON
admet-916	136	41	permeation	permeation	NOUN
admet-916	136	42	and	and	CCONJ
admet-916	136	43	the	the	DET
admet-916	136	44	effects	effect	NOUN
admet-916	136	45	of	of	ADP
admet-916	136	46	ph	ph	NOUN
admet-916	136	47	on	on	ADP
admet-916	136	48	this	this	DET
admet-916	136	49	type	type	NOUN
admet-916	136	50	of	of	ADP
admet-916	136	51	permeation	permeation	NOUN
admet-916	136	52	.	.	PUNCT
admet-916	137	1	table	table	NOUN
admet-916	138	1	3	3	NUM
admet-916	138	2	.	.	PUNCT
admet-916	139	1	mean	mean	ADJ
admet-916	139	2	values	value	NOUN
admet-916	139	3	(	(	PUNCT
admet-916	139	4	n	n	NOUN
admet-916	139	5	=	=	SYM
admet-916	139	6	3	3	NUM
admet-916	139	7	)	)	PUNCT
admet-916	139	8	of	of	ADP
admet-916	139	9	the	the	DET
admet-916	139	10	apparent	apparent	ADJ
admet-916	139	11	permeation	permeation	NOUN
admet-916	139	12	coefficients	coefficient	NOUN
admet-916	139	13	(	(	PUNCT
admet-916	139	14	papp	papp	NOUN
admet-916	139	15	)	)	PUNCT
admet-916	139	16	of	of	ADP
admet-916	139	17	metformin	metformin	NOUN
admet-916	139	18	,	,	PUNCT
admet-916	139	19	the	the	DET
admet-916	139	20	recovery	recovery	NOUN
admet-916	139	21	of	of	ADP
admet-916	139	22	the	the	DET
admet-916	139	23	substance	substance	NOUN
admet-916	139	24	not	not	PART
admet-916	139	25	retained	retain	VERB
admet-916	139	26	by	by	ADP
admet-916	139	27	the	the	DET
admet-916	139	28	membrane	membrane	NOUN
admet-916	139	29	(	(	PUNCT
admet-916	139	30	r	r	NOUN
admet-916	139	31	)	)	PUNCT
admet-916	139	32	and	and	CCONJ
admet-916	139	33	percentage	percentage	NOUN
admet-916	139	34	of	of	ADP
admet-916	139	35	calculated	calculated	ADJ
admet-916	139	36	(	(	PUNCT
admet-916	139	37	non)ionized	non)ionized	ADJ
admet-916	139	38	species	specie	NOUN
admet-916	139	39	(	(	PUNCT
admet-916	139	40	bh2	bh2	X
admet-916	139	41	2+/bh+/b	2+/bh+/b	NUM
admet-916	139	42	)	)	PUNCT
admet-916	139	43	at	at	ADP
admet-916	139	44	different	different	ADJ
admet-916	139	45	ph	ph	ADJ
admet-916	139	46	values	value	NOUN
admet-916	139	47	of	of	ADP
admet-916	139	48	donor	donor	NOUN
admet-916	139	49	compartment	compartment	NOUN
admet-916	139	50	.	.	PUNCT
admet-916	140	1	ph	ph	ADJ
admet-916	140	2	papp	papp	NOUN
admet-916	140	3	(	(	PUNCT
admet-916	140	4	×	×	NOUN
admet-916	140	5	10	10	NUM
admet-916	140	6	-	-	SYM
admet-916	140	7	8	8	NUM
admet-916	140	8	cm	cm	NUM
admet-916	140	9	s-1	s-1	NOUN
admet-916	140	10	)	)	PUNCT
admet-916	140	11	±	±	PROPN
admet-916	140	12	sd	sd	ADP
admet-916	140	13	r(%	r(%	PROPN
admet-916	140	14	)	)	PUNCT
admet-916	140	15	±	±	PROPN
admet-916	140	16	sd	sd	ADP
admet-916	140	17	bh2	bh2	VERB
admet-916	140	18	2+/bh+/b	2+/bh+/b	PROPN
admet-916	140	19	(	(	PUNCT
admet-916	140	20	%	%	INTJ
admet-916	140	21	)	)	PUNCT
admet-916	140	22	7.4	7.4	NUM
admet-916	140	23	29.82	29.82	NUM
admet-916	140	24	±	±	NUM
admet-916	140	25	1.095	1.095	NUM
admet-916	140	26	96.19	96.19	NUM
admet-916	140	27	±	±	NUM
admet-916	140	28	4.92	4.92	NUM
admet-916	140	29	0.0025	0.0025	NUM
admet-916	140	30	/	/	SYM
admet-916	140	31	99.99	99.99	NUM
admet-916	140	32	/	/	SYM
admet-916	140	33	0.008	0.008	NUM
admet-916	140	34	6.8	6.8	NUM
admet-916	140	35	9.83	9.83	NUM
admet-916	140	36	±	±	NUM
admet-916	140	37	0.199	0.199	NUM
admet-916	140	38	90.00	90.00	NUM
admet-916	140	39	±	±	NUM
admet-916	140	40	2.73	2.73	NUM
admet-916	140	41	0.010	0.010	NUM
admet-916	140	42	/	/	SYM
admet-916	140	43	99.99	99.99	NUM
admet-916	140	44	/	/	SYM
admet-916	140	45	0.002	0.002	NUM
admet-916	140	46	4.5	4.5	NUM
admet-916	140	47	9.79	9.79	NUM
admet-916	140	48	±	±	NOUN
admet-916	140	49	0.234	0.234	NUM
admet-916	140	50	90.37	90.37	NUM
admet-916	140	51	±	±	NUM
admet-916	140	52	3.20	3.20	NUM
admet-916	140	53	1.96	1.96	NUM
admet-916	140	54	/	/	SYM
admet-916	140	55	98.04	98.04	NUM
admet-916	140	56	/	/	SYM
admet-916	140	57	9.8	9.8	NUM
admet-916	140	58	×	×	NOUN
admet-916	140	59	10	10	NUM
admet-916	140	60	-	-	SYM
admet-916	140	61	6	6	NUM
admet-916	140	62	2.0	2.0	NUM
admet-916	140	63	5.53	5.53	NUM
admet-916	140	64	±	±	NUM
admet-916	140	65	0.556	0.556	NUM
admet-916	140	66	85.31	85.31	NUM
admet-916	140	67	±	±	NUM
admet-916	140	68	4.45	4.45	NUM
admet-916	140	69	86.32	86.32	NUM
admet-916	140	70	/	/	SYM
admet-916	140	71	13.68	13.68	NUM
admet-916	140	72	/	/	SYM
admet-916	140	73	4.33	4.33	NUM
admet-916	140	74	×	×	NOUN
admet-916	140	75	10	10	NUM
admet-916	140	76	-	-	SYM
admet-916	140	77	9	9	NUM
admet-916	140	78	http://dx.doi.org/10.5599/admet.916	http://dx.doi.org/10.5599/admet.916	PROPN
admet-916	140	79	alisa	alisa	PROPN
admet-916	140	80	elezović	elezović	PROPN
admet-916	140	81	et	et	PROPN
admet-916	140	82	al	al	PROPN
admet-916	140	83	.	.	PROPN
admet-916	140	84	admet	admet	PROPN
admet-916	140	85	&	&	CCONJ
admet-916	140	86	dmpk	dmpk	PROPN
admet-916	140	87	9(1	9(1	NUM
admet-916	140	88	)	)	PUNCT
admet-916	140	89	(	(	PUNCT
admet-916	140	90	2021	2021	NUM
admet-916	140	91	)	)	PUNCT
admet-916	140	92	57	57	NUM
admet-916	140	93	-	-	SYM
admet-916	140	94	68	68	NUM
admet-916	140	95	64	64	NUM
admet-916	140	96	figure	figure	NOUN
admet-916	140	97	3	3	NUM
admet-916	140	98	.	.	PUNCT
admet-916	140	99	overall	overall	ADJ
admet-916	140	100	permeated	permeate	VERB
admet-916	140	101	amount	amount	NOUN
admet-916	140	102	of	of	ADP
admet-916	140	103	metformin	metformin	NOUN
admet-916	140	104	across	across	ADP
admet-916	140	105	the	the	DET
admet-916	140	106	artificial	artificial	ADJ
admet-916	140	107	membrane	membrane	NOUN
admet-916	140	108	at	at	ADP
admet-916	140	109	different	different	ADJ
admet-916	140	110	ph	ph	ADJ
admet-916	140	111	values	value	NOUN
admet-916	140	112	of	of	ADP
admet-916	140	113	donor	donor	NOUN
admet-916	140	114	compartment	compartment	NOUN
admet-916	140	115	.	.	PUNCT
admet-916	141	1	at	at	ADP
admet-916	141	2	ph	ph	PROPN
admet-916	141	3	2.0	2.0	NUM
admet-916	141	4	(	(	PUNCT
admet-916	141	5	which	which	PRON
admet-916	141	6	corresponds	correspond	VERB
admet-916	141	7	to	to	ADP
admet-916	141	8	the	the	DET
admet-916	141	9	gastric	gastric	ADJ
admet-916	141	10	ph	ph	VERB
admet-916	141	11	)	)	PUNCT
admet-916	141	12	most	most	ADJ
admet-916	141	13	of	of	ADP
admet-916	141	14	metformin	metformin	NOUN
admet-916	141	15	(	(	PUNCT
admet-916	141	16	86.32	86.32	NUM
admet-916	141	17	%	%	NOUN
admet-916	141	18	)	)	PUNCT
admet-916	141	19	is	be	AUX
admet-916	141	20	in	in	ADP
admet-916	141	21	diprotonated	diprotonate	VERB
admet-916	141	22	form	form	NOUN
admet-916	141	23	,	,	PUNCT
admet-916	141	24	i.e.	i.e.	X
admet-916	141	25	it	it	PRON
admet-916	141	26	is	be	AUX
admet-916	141	27	in	in	ADP
admet-916	141	28	the	the	DET
admet-916	141	29	form	form	NOUN
admet-916	141	30	of	of	ADP
admet-916	141	31	a	a	DET
admet-916	141	32	double	double	ADJ
admet-916	141	33	positively	positively	ADV
admet-916	141	34	charged	charge	VERB
admet-916	141	35	ion	ion	NOUN
admet-916	141	36	.	.	PUNCT
admet-916	142	1	in	in	ADP
admet-916	142	2	the	the	DET
admet-916	142	3	protonated	protonate	VERB
admet-916	142	4	form	form	NOUN
admet-916	142	5	,	,	PUNCT
admet-916	142	6	positively	positively	ADV
admet-916	142	7	charged	charge	VERB
admet-916	142	8	metformin	metformin	NOUN
admet-916	142	9	at	at	ADP
admet-916	142	10	this	this	DET
admet-916	142	11	ph	ph	ADJ
admet-916	142	12	value	value	NOUN
admet-916	142	13	is	be	AUX
admet-916	142	14	present	present	ADJ
admet-916	142	15	at	at	ADP
admet-916	142	16	13.68	13.68	NUM
admet-916	142	17	%	%	NOUN
admet-916	142	18	,	,	PUNCT
admet-916	142	19	while	while	SCONJ
admet-916	142	20	the	the	DET
admet-916	142	21	non	non	ADJ
admet-916	142	22	-	-	ADJ
admet-916	142	23	ionized	ionized	ADJ
admet-916	142	24	form	form	NOUN
admet-916	142	25	is	be	AUX
admet-916	142	26	represented	represent	VERB
admet-916	142	27	by	by	ADP
admet-916	142	28	only	only	ADV
admet-916	142	29	4.33	4.33	NUM
admet-916	142	30	×	×	NOUN
admet-916	142	31	10	10	NUM
admet-916	142	32	-	-	SYM
admet-916	142	33	9	9	NUM
admet-916	142	34	%	%	NOUN
admet-916	142	35	.	.	PUNCT
admet-916	143	1	these	these	DET
admet-916	143	2	data	datum	NOUN
admet-916	143	3	point	point	NOUN
admet-916	143	4	to	to	ADP
admet-916	143	5	the	the	DET
admet-916	143	6	fact	fact	NOUN
admet-916	143	7	that	that	SCONJ
admet-916	143	8	metformin	metformin	NOUN
admet-916	143	9	at	at	ADP
admet-916	143	10	the	the	DET
admet-916	143	11	ph	ph	ADJ
admet-916	143	12	value	value	NOUN
admet-916	143	13	of	of	ADP
admet-916	143	14	the	the	DET
admet-916	143	15	stomach	stomach	NOUN
admet-916	143	16	is	be	AUX
admet-916	143	17	very	very	ADV
admet-916	143	18	difficult	difficult	ADJ
admet-916	143	19	to	to	PART
admet-916	143	20	passively	passively	ADV
admet-916	143	21	permeate	permeate	VERB
admet-916	143	22	through	through	ADP
admet-916	143	23	physiological	physiological	ADJ
admet-916	143	24	membranes	membrane	NOUN
admet-916	143	25	,	,	PUNCT
admet-916	143	26	which	which	PRON
admet-916	143	27	the	the	DET
admet-916	143	28	obtained	obtain	VERB
admet-916	143	29	results	result	NOUN
admet-916	143	30	confirm	confirm	VERB
admet-916	143	31	.	.	PUNCT
admet-916	144	1	table	table	NOUN
admet-916	144	2	3	3	NUM
admet-916	144	3	shows	show	VERB
admet-916	144	4	that	that	SCONJ
admet-916	144	5	the	the	DET
admet-916	144	6	papp	papp	NOUN
admet-916	144	7	value	value	NOUN
admet-916	144	8	was	be	AUX
admet-916	144	9	5.53	5.53	NUM
admet-916	144	10	×	×	NOUN
admet-916	144	11	10	10	NUM
admet-916	144	12	-	-	SYM
admet-916	144	13	8	8	NUM
admet-916	144	14	cm	cm	NUM
admet-916	144	15	s-1	s-1	NOUN
admet-916	144	16	,	,	PUNCT
admet-916	144	17	very	very	ADV
admet-916	144	18	low	low	ADJ
admet-916	144	19	due	due	ADP
admet-916	144	20	to	to	ADP
admet-916	144	21	the	the	DET
admet-916	144	22	low	low	ADJ
admet-916	144	23	permeability	permeability	NOUN
admet-916	144	24	of	of	ADP
admet-916	144	25	the	the	DET
admet-916	144	26	substance	substance	NOUN
admet-916	144	27	at	at	ADP
admet-916	144	28	ph	ph	PROPN
admet-916	144	29	2.0	2.0	NUM
admet-916	144	30	.	.	PUNCT
admet-916	145	1	metformin	metformin	NOUN
admet-916	145	2	is	be	AUX
admet-916	145	3	at	at	ADP
admet-916	145	4	gastric	gastric	ADJ
admet-916	145	5	ph	ph	VERB
admet-916	145	6	,	,	PUNCT
admet-916	145	7	a	a	DET
admet-916	145	8	highly	highly	ADV
admet-916	145	9	ionized	ionized	ADJ
admet-916	145	10	molecule	molecule	NOUN
admet-916	145	11	and	and	CCONJ
admet-916	145	12	as	as	ADP
admet-916	145	13	such	such	ADJ
admet-916	145	14	can	can	AUX
admet-916	145	15	not	not	PART
admet-916	145	16	passively	passively	ADV
admet-916	145	17	permeate	permeate	VERB
admet-916	145	18	through	through	ADP
admet-916	145	19	physiological	physiological	ADJ
admet-916	145	20	membranes	membrane	NOUN
admet-916	145	21	.	.	PUNCT
admet-916	146	1	the	the	DET
admet-916	146	2	recovery	recovery	NOUN
admet-916	146	3	value	value	NOUN
admet-916	146	4	was	be	AUX
admet-916	146	5	85.31	85.31	NUM
admet-916	146	6	%	%	NOUN
admet-916	146	7	,	,	PUNCT
admet-916	146	8	indicating	indicate	VERB
admet-916	146	9	a	a	DET
admet-916	146	10	higher	high	ADJ
admet-916	146	11	retention	retention	NOUN
admet-916	146	12	of	of	ADP
admet-916	146	13	metformin	metformin	NOUN
admet-916	146	14	in	in	ADP
admet-916	146	15	the	the	DET
admet-916	146	16	artificial	artificial	ADJ
admet-916	146	17	membrane	membrane	NOUN
admet-916	146	18	than	than	ADP
admet-916	146	19	at	at	ADP
admet-916	146	20	other	other	ADJ
admet-916	146	21	ph	ph	ADJ
admet-916	146	22	values	value	NOUN
admet-916	146	23	of	of	ADP
admet-916	146	24	the	the	DET
admet-916	146	25	donor	donor	NOUN
admet-916	146	26	compartment	compartment	NOUN
admet-916	146	27	,	,	PUNCT
admet-916	146	28	probably	probably	ADV
admet-916	146	29	due	due	ADP
admet-916	146	30	to	to	ADP
admet-916	146	31	the	the	DET
admet-916	146	32	affinity	affinity	NOUN
admet-916	146	33	of	of	ADP
admet-916	146	34	metformin	metformin	NOUN
admet-916	146	35	for	for	ADP
admet-916	146	36	membrane	membrane	NOUN
admet-916	146	37	components	component	NOUN
admet-916	146	38	made	make	VERB
admet-916	146	39	of	of	ADP
admet-916	146	40	cellulose	cellulose	NOUN
admet-916	146	41	nitrate	nitrate	NOUN
admet-916	146	42	and	and	CCONJ
admet-916	146	43	phospholipids	phospholipid	NOUN
admet-916	146	44	from	from	ADP
admet-916	146	45	the	the	DET
admet-916	146	46	impregnation	impregnation	NOUN
admet-916	146	47	solution	solution	NOUN
admet-916	146	48	.	.	PUNCT
admet-916	147	1	at	at	ADP
admet-916	147	2	ph	ph	PROPN
admet-916	147	3	4.5	4.5	NUM
admet-916	147	4	,	,	PUNCT
admet-916	147	5	the	the	DET
admet-916	147	6	share	share	NOUN
admet-916	147	7	of	of	ADP
admet-916	147	8	the	the	DET
admet-916	147	9	diprotonated	diprotonate	VERB
admet-916	147	10	form	form	NOUN
admet-916	147	11	of	of	ADP
admet-916	147	12	metformin	metformin	NOUN
admet-916	147	13	is	be	AUX
admet-916	147	14	1.95	1.95	NUM
admet-916	147	15	%	%	NOUN
admet-916	147	16	,	,	PUNCT
admet-916	147	17	while	while	SCONJ
admet-916	147	18	the	the	DET
admet-916	147	19	single	single	ADJ
admet-916	147	20	positively	positively	ADV
admet-916	147	21	charged	charge	VERB
admet-916	147	22	form	form	NOUN
admet-916	147	23	dominates	dominate	VERB
admet-916	147	24	(	(	PUNCT
admet-916	147	25	98.04	98.04	NUM
admet-916	147	26	%	%	NOUN
admet-916	147	27	)	)	PUNCT
admet-916	147	28	.	.	PUNCT
admet-916	148	1	non	non	ADJ
admet-916	148	2	-	-	ADJ
admet-916	148	3	ionized	ionized	ADJ
admet-916	148	4	form	form	NOUN
admet-916	148	5	of	of	ADP
admet-916	148	6	the	the	DET
admet-916	148	7	molecule	molecule	NOUN
admet-916	148	8	is	be	AUX
admet-916	148	9	present	present	ADJ
admet-916	148	10	in	in	ADP
admet-916	148	11	a	a	DET
admet-916	148	12	percentage	percentage	NOUN
admet-916	148	13	of	of	ADP
admet-916	148	14	9.8	9.8	NUM
admet-916	148	15	x	x	SYM
admet-916	148	16	10	10	NUM
admet-916	148	17	-	-	SYM
admet-916	148	18	6	6	NUM
admet-916	148	19	%	%	NOUN
admet-916	148	20	.	.	PUNCT
admet-916	149	1	although	although	SCONJ
admet-916	149	2	present	present	ADJ
admet-916	149	3	in	in	ADP
admet-916	149	4	extremely	extremely	ADV
admet-916	149	5	low	low	ADJ
admet-916	149	6	percentage	percentage	NOUN
admet-916	149	7	,	,	PUNCT
admet-916	149	8	the	the	DET
admet-916	149	9	non	non	ADJ
admet-916	149	10	-	-	ADJ
admet-916	149	11	ionized	ionized	ADJ
admet-916	149	12	form	form	NOUN
admet-916	149	13	of	of	ADP
admet-916	149	14	metformin	metformin	NOUN
admet-916	149	15	is	be	AUX
admet-916	149	16	still	still	ADV
admet-916	149	17	insufficient	insufficient	ADJ
admet-916	149	18	for	for	ADP
admet-916	149	19	unobstructed	unobstructed	ADJ
admet-916	149	20	passive	passive	ADJ
admet-916	149	21	permeation	permeation	NOUN
admet-916	149	22	,	,	PUNCT
admet-916	149	23	and	and	CCONJ
admet-916	149	24	the	the	DET
admet-916	149	25	papp	papp	NOUN
admet-916	149	26	value	value	NOUN
admet-916	149	27	was	be	AUX
admet-916	149	28	9.79	9.79	NUM
admet-916	149	29	×10	×10	NOUN
admet-916	149	30	-	-	SYM
admet-916	149	31	8	8	NUM
admet-916	149	32	cm	cm	NOUN
admet-916	149	33	/	/	SYM
admet-916	149	34	s	s	NOUN
admet-916	149	35	at	at	ADP
admet-916	149	36	this	this	DET
admet-916	149	37	ph	ph	NOUN
admet-916	149	38	.	.	PUNCT
admet-916	150	1	the	the	DET
admet-916	150	2	ph	ph	ADJ
admet-916	150	3	value	value	NOUN
admet-916	150	4	of	of	ADP
admet-916	150	5	4.5	4.5	NUM
admet-916	150	6	is	be	AUX
admet-916	150	7	present	present	ADJ
admet-916	150	8	at	at	ADP
admet-916	150	9	the	the	DET
admet-916	150	10	level	level	NOUN
admet-916	150	11	of	of	ADP
admet-916	150	12	the	the	DET
admet-916	150	13	duodenum	duodenum	NOUN
admet-916	150	14	from	from	ADP
admet-916	150	15	where	where	SCONJ
admet-916	150	16	in	in	ADP
admet-916	150	17	vivo	vivo	NOUN
admet-916	150	18	metformin	metformin	NOUN
admet-916	150	19	absorption	absorption	NOUN
admet-916	150	20	will	will	AUX
admet-916	150	21	start	start	VERB
admet-916	150	22	to	to	PART
admet-916	150	23	take	take	VERB
admet-916	150	24	place	place	NOUN
admet-916	150	25	.	.	PUNCT
admet-916	151	1	at	at	ADP
admet-916	151	2	ph	ph	ADJ
admet-916	151	3	values	value	NOUN
admet-916	151	4	of	of	ADP
admet-916	151	5	6.8	6.8	NUM
admet-916	151	6	,	,	PUNCT
admet-916	151	7	metformin	metformin	NOUN
admet-916	151	8	is	be	AUX
admet-916	151	9	found	find	VERB
admet-916	151	10	in	in	ADP
admet-916	151	11	the	the	DET
admet-916	151	12	non	non	ADJ
admet-916	151	13	-	-	ADJ
admet-916	151	14	ionized	ionized	ADJ
admet-916	151	15	form	form	NOUN
admet-916	151	16	in	in	ADP
admet-916	151	17	portion	portion	NOUN
admet-916	151	18	of	of	ADP
admet-916	151	19	0.0019	0.0019	NUM
admet-916	151	20	%	%	NOUN
admet-916	151	21	.	.	PUNCT
admet-916	152	1	passive	passive	ADJ
admet-916	152	2	permeation	permeation	NOUN
admet-916	152	3	in	in	ADP
admet-916	152	4	this	this	DET
admet-916	152	5	case	case	NOUN
admet-916	152	6	is	be	AUX
admet-916	152	7	more	more	ADV
admet-916	152	8	pronounced	pronounced	ADJ
admet-916	152	9	than	than	ADP
admet-916	152	10	at	at	ADP
admet-916	152	11	lower	low	ADJ
admet-916	152	12	ph	ph	ADJ
admet-916	152	13	values	value	NOUN
admet-916	152	14	.	.	PUNCT
admet-916	153	1	generally	generally	ADV
admet-916	153	2	,	,	PUNCT
admet-916	153	3	in	in	ADP
admet-916	153	4	vivo	vivo	NOUN
admet-916	153	5	metformin	metformin	NOUN
admet-916	153	6	absorption	absorption	NOUN
admet-916	153	7	mainly	mainly	ADV
admet-916	153	8	takes	take	VERB
admet-916	153	9	place	place	NOUN
admet-916	153	10	from	from	ADP
admet-916	153	11	git	git	NOUN
admet-916	153	12	regions	region	NOUN
admet-916	153	13	where	where	SCONJ
admet-916	153	14	the	the	DET
admet-916	153	15	ph	ph	ADJ
admet-916	153	16	value	value	NOUN
admet-916	153	17	is	be	AUX
admet-916	153	18	6.8	6.8	NUM
admet-916	153	19	.	.	PUNCT
admet-916	154	1	however	however	ADV
admet-916	154	2	,	,	PUNCT
admet-916	154	3	in	in	ADP
admet-916	154	4	vivo	vivo	ADJ
admet-916	154	5	absorption	absorption	NOUN
admet-916	154	6	is	be	AUX
admet-916	154	7	aided	aid	VERB
admet-916	154	8	by	by	ADP
admet-916	154	9	a	a	DET
admet-916	154	10	number	number	NOUN
admet-916	154	11	of	of	ADP
admet-916	154	12	protein	protein	NOUN
admet-916	154	13	carriers	carrier	NOUN
admet-916	154	14	and	and	CCONJ
admet-916	154	15	transporters	transporter	NOUN
admet-916	154	16	located	locate	VERB
admet-916	154	17	along	along	ADP
admet-916	154	18	the	the	DET
admet-916	154	19	length	length	NOUN
admet-916	154	20	of	of	ADP
admet-916	154	21	the	the	DET
admet-916	154	22	intestinal	intestinal	ADJ
admet-916	154	23	mucosa	mucosa	NOUN
admet-916	154	24	that	that	PRON
admet-916	154	25	facilitate	facilitate	VERB
admet-916	154	26	and	and	CCONJ
admet-916	154	27	enable	enable	VERB
admet-916	154	28	cellular	cellular	ADJ
admet-916	154	29	uptake	uptake	NOUN
admet-916	154	30	of	of	ADP
admet-916	154	31	metformin	metformin	NOUN
admet-916	154	32	from	from	ADP
admet-916	154	33	the	the	DET
admet-916	154	34	apical	apical	ADJ
admet-916	154	35	to	to	ADP
admet-916	154	36	the	the	DET
admet-916	154	37	basolateral	basolateral	ADJ
admet-916	154	38	membrane	membrane	NOUN
admet-916	154	39	of	of	ADP
admet-916	154	40	enterocytes	enterocyte	NOUN
admet-916	154	41	.	.	PUNCT
admet-916	155	1	therefore	therefore	ADV
admet-916	155	2	,	,	PUNCT
admet-916	155	3	an	an	DET
admet-916	155	4	in	in	ADP
admet-916	155	5	vitro	vitro	X
admet-916	155	6	model	model	NOUN
admet-916	155	7	based	base	VERB
admet-916	155	8	exclusively	exclusively	ADV
admet-916	155	9	on	on	ADP
admet-916	155	10	passive	passive	ADJ
admet-916	155	11	transport	transport	NOUN
admet-916	155	12	could	could	AUX
admet-916	155	13	not	not	PART
admet-916	155	14	adequately	adequately	ADV
admet-916	155	15	map	map	VERB
admet-916	155	16	events	event	NOUN
admet-916	155	17	at	at	ADP
admet-916	155	18	physiological	physiological	ADJ
admet-916	155	19	ph	ph	NOUN
admet-916	155	20	6.8	6.8	NUM
admet-916	155	21	,	,	PUNCT
admet-916	155	22	but	but	CCONJ
admet-916	155	23	only	only	ADV
admet-916	155	24	the	the	DET
admet-916	155	25	passive	passive	ADJ
admet-916	155	26	component	component	NOUN
admet-916	155	27	of	of	ADP
admet-916	155	28	membrane	membrane	NOUN
admet-916	155	29	transport	transport	NOUN
admet-916	155	30	.	.	PUNCT
admet-916	156	1	since	since	SCONJ
admet-916	156	2	the	the	DET
admet-916	156	3	nonionized	nonionize	VERB
admet-916	156	4	content	content	NOUN
admet-916	156	5	is	be	AUX
admet-916	156	6	lower	low	ADJ
admet-916	156	7	than	than	ADP
admet-916	156	8	at	at	ADP
admet-916	156	9	ph	ph	NOUN
admet-916	156	10	7.4	7.4	NUM
admet-916	156	11	,	,	PUNCT
admet-916	156	12	the	the	DET
admet-916	156	13	permeation	permeation	NOUN
admet-916	156	14	rate	rate	NOUN
admet-916	156	15	is	be	AUX
admet-916	156	16	lower	low	ADJ
admet-916	156	17	at	at	ADP
admet-916	156	18	this	this	DET
admet-916	156	19	ph	ph	NOUN
admet-916	156	20	of	of	ADP
admet-916	156	21	the	the	DET
admet-916	156	22	environment	environment	NOUN
admet-916	156	23	.	.	PUNCT
admet-916	157	1	the	the	DET
admet-916	157	2	mean	mean	ADJ
admet-916	157	3	papp	papp	NOUN
admet-916	157	4	value	value	NOUN
admet-916	157	5	shown	show	VERB
admet-916	157	6	in	in	ADP
admet-916	157	7	table	table	NOUN
admet-916	157	8	3	3	NUM
admet-916	157	9	was	be	AUX
admet-916	157	10	9.83	9.83	NUM
admet-916	157	11	×10	×10	NOUN
admet-916	157	12	-	-	SYM
admet-916	157	13	8	8	NUM
admet-916	157	14	cm	cm	NUM
admet-916	157	15	s-1	s-1	NOUN
admet-916	157	16	.	.	PUNCT
admet-916	158	1	admet	admet	PROPN
admet-916	158	2	&	&	CCONJ
admet-916	158	3	dmpk	dmpk	PROPN
admet-916	158	4	9(1	9(1	NUM
admet-916	158	5	)	)	PUNCT
admet-916	158	6	(	(	PUNCT
admet-916	158	7	2021	2021	NUM
admet-916	158	8	)	)	PUNCT
admet-916	158	9	57	57	NUM
admet-916	158	10	-	-	SYM
admet-916	158	11	68	68	NUM
admet-916	158	12	passive	passive	ADJ
admet-916	158	13	transport	transport	NOUN
admet-916	158	14	of	of	ADP
admet-916	158	15	ketoprofen	ketoprofen	NOUN
admet-916	158	16	and	and	CCONJ
admet-916	158	17	metformin	metformin	PROPN
admet-916	158	18	doi	doi	PROPN
admet-916	158	19	:	:	PUNCT
admet-916	158	20	http://dx.doi.org/10.5599/admet.916	http://dx.doi.org/10.5599/admet.916	PROPN
admet-916	158	21	65	65	NUM
admet-916	158	22	at	at	ADP
admet-916	158	23	ph	ph	PROPN
admet-916	158	24	7.4	7.4	NUM
admet-916	158	25	metformin	metformin	NOUN
admet-916	158	26	is	be	AUX
admet-916	158	27	present	present	ADJ
admet-916	158	28	in	in	ADP
admet-916	158	29	the	the	DET
admet-916	158	30	non	non	ADJ
admet-916	158	31	-	-	ADJ
admet-916	158	32	ionized	ionized	ADJ
admet-916	158	33	form	form	NOUN
admet-916	158	34	0.008	0.008	NUM
admet-916	158	35	%	%	NOUN
admet-916	158	36	.	.	PUNCT
admet-916	159	1	although	although	SCONJ
admet-916	159	2	the	the	DET
admet-916	159	3	concentration	concentration	NOUN
admet-916	159	4	of	of	ADP
admet-916	159	5	the	the	DET
admet-916	159	6	uncharged	uncharged	ADJ
admet-916	159	7	form	form	NOUN
admet-916	159	8	is	be	AUX
admet-916	159	9	extremely	extremely	ADV
admet-916	159	10	low	low	ADJ
admet-916	159	11	,	,	PUNCT
admet-916	159	12	it	it	PRON
admet-916	159	13	is	be	AUX
admet-916	159	14	the	the	DET
admet-916	159	15	highest	high	ADJ
admet-916	159	16	at	at	ADP
admet-916	159	17	the	the	DET
admet-916	159	18	studied	studied	ADJ
admet-916	159	19	ph	ph	ADJ
admet-916	159	20	values	value	NOUN
admet-916	159	21	and	and	CCONJ
admet-916	159	22	as	as	SCONJ
admet-916	159	23	such	such	ADJ
admet-916	159	24	shows	show	VERB
admet-916	159	25	the	the	DET
admet-916	159	26	best	good	ADJ
admet-916	159	27	permeation	permeation	NOUN
admet-916	159	28	rate	rate	NOUN
admet-916	159	29	and	and	CCONJ
admet-916	159	30	extent	extent	NOUN
admet-916	159	31	through	through	ADP
admet-916	159	32	the	the	DET
admet-916	159	33	artificial	artificial	ADJ
admet-916	159	34	membrane	membrane	NOUN
admet-916	159	35	.	.	PUNCT
admet-916	160	1	the	the	DET
admet-916	160	2	ph	ph	ADJ
admet-916	160	3	value	value	NOUN
admet-916	160	4	of	of	ADP
admet-916	160	5	the	the	DET
admet-916	160	6	donor	donor	NOUN
admet-916	160	7	compartment	compartment	NOUN
admet-916	160	8	was	be	AUX
admet-916	160	9	the	the	DET
admet-916	160	10	furthest	furth	ADJ
admet-916	160	11	from	from	ADP
admet-916	160	12	the	the	DET
admet-916	160	13	lower	low	ADJ
admet-916	160	14	pka	pka	PROPN
admet-916	160	15	value	value	NOUN
admet-916	160	16	for	for	ADP
admet-916	160	17	metformin	metformin	NOUN
admet-916	160	18	(	(	PUNCT
admet-916	160	19	2.8	2.8	NUM
admet-916	160	20	)	)	PUNCT
admet-916	160	21	,	,	PUNCT
admet-916	160	22	which	which	PRON
admet-916	160	23	favored	favor	VERB
admet-916	160	24	its	its	PRON
admet-916	160	25	existence	existence	NOUN
admet-916	160	26	in	in	ADP
admet-916	160	27	non	non	ADJ
admet-916	160	28	-	-	ADJ
admet-916	160	29	ionized	ionized	ADJ
admet-916	160	30	form	form	NOUN
admet-916	160	31	,	,	PUNCT
admet-916	160	32	and	and	CCONJ
admet-916	160	33	enabled	enable	VERB
admet-916	160	34	its	its	PRON
admet-916	160	35	passive	passive	ADJ
admet-916	160	36	permeation	permeation	NOUN
admet-916	160	37	across	across	ADP
admet-916	160	38	the	the	DET
admet-916	160	39	artificial	artificial	ADJ
admet-916	160	40	membrane	membrane	NOUN
admet-916	160	41	.	.	PUNCT
admet-916	161	1	from	from	ADP
admet-916	161	2	the	the	DET
admet-916	161	3	results	result	NOUN
admet-916	161	4	shown	show	VERB
admet-916	161	5	in	in	ADP
admet-916	161	6	table	table	NOUN
admet-916	161	7	3	3	NUM
admet-916	161	8	,	,	PUNCT
admet-916	161	9	it	it	PRON
admet-916	161	10	can	can	AUX
admet-916	161	11	be	be	AUX
admet-916	161	12	seen	see	VERB
admet-916	161	13	that	that	SCONJ
admet-916	161	14	the	the	DET
admet-916	161	15	mean	mean	ADJ
admet-916	161	16	papp	papp	NOUN
admet-916	161	17	at	at	ADP
admet-916	161	18	ph	ph	PROPN
admet-916	161	19	7.4	7.4	NUM
admet-916	161	20	was	be	AUX
admet-916	161	21	2.98	2.98	NUM
admet-916	161	22	×	×	NOUN
admet-916	161	23	10	10	NUM
admet-916	161	24	-7	-7	NOUN
admet-916	161	25	cm	cm	NOUN
admet-916	161	26	s	s	PART
admet-916	161	27	-1	-1	NOUN
admet-916	161	28	.	.	PUNCT
admet-916	162	1	although	although	SCONJ
admet-916	162	2	this	this	DET
admet-916	162	3	permeation	permeation	NOUN
admet-916	162	4	rate	rate	NOUN
admet-916	162	5	is	be	AUX
admet-916	162	6	low	low	ADJ
admet-916	162	7	compared	compare	VERB
admet-916	162	8	to	to	ADP
admet-916	162	9	substances	substance	NOUN
admet-916	162	10	that	that	PRON
admet-916	162	11	show	show	VERB
admet-916	162	12	good	good	ADJ
admet-916	162	13	permeability	permeability	NOUN
admet-916	162	14	,	,	PUNCT
admet-916	162	15	this	this	PRON
admet-916	162	16	is	be	AUX
admet-916	162	17	the	the	DET
admet-916	162	18	highest	high	ADJ
admet-916	162	19	value	value	NOUN
admet-916	162	20	of	of	ADP
admet-916	162	21	permeation	permeation	NOUN
admet-916	162	22	obtained	obtain	VERB
admet-916	162	23	in	in	ADP
admet-916	162	24	this	this	DET
admet-916	162	25	experimental	experimental	ADJ
admet-916	162	26	work	work	NOUN
admet-916	162	27	due	due	ADP
admet-916	162	28	to	to	ADP
admet-916	162	29	the	the	DET
admet-916	162	30	fact	fact	NOUN
admet-916	162	31	that	that	SCONJ
admet-916	162	32	at	at	ADP
admet-916	162	33	these	these	DET
admet-916	162	34	ph	ph	ADJ
admet-916	162	35	values	value	NOUN
admet-916	162	36	the	the	DET
admet-916	162	37	highest	high	ADJ
admet-916	162	38	percentage	percentage	NOUN
admet-916	162	39	of	of	ADP
admet-916	162	40	non	non	ADJ
admet-916	162	41	-	-	ADJ
admet-916	162	42	ionized	ionized	ADJ
admet-916	162	43	form	form	NOUN
admet-916	162	44	is	be	AUX
admet-916	162	45	present	present	ADJ
admet-916	162	46	compared	compare	VERB
admet-916	162	47	to	to	ADP
admet-916	162	48	other	other	ADJ
admet-916	162	49	studied	study	VERB
admet-916	162	50	ph	ph	ADJ
admet-916	162	51	values	value	NOUN
admet-916	162	52	.	.	PUNCT
admet-916	163	1	thus	thus	ADV
admet-916	163	2	,	,	PUNCT
admet-916	163	3	metformin	metformin	NOUN
admet-916	163	4	is	be	AUX
admet-916	163	5	a	a	DET
admet-916	163	6	low	low	ADJ
admet-916	163	7	permeable	permeable	ADJ
admet-916	163	8	compound	compound	NOUN
admet-916	163	9	whose	whose	DET
admet-916	163	10	absorption	absorption	NOUN
admet-916	163	11	is	be	AUX
admet-916	163	12	more	more	ADV
admet-916	163	13	favored	favor	VERB
admet-916	163	14	by	by	ADP
admet-916	163	15	alkaline	alkaline	ADJ
admet-916	163	16	ph	ph	ADJ
admet-916	163	17	values	value	NOUN
admet-916	163	18	(	(	PUNCT
admet-916	163	19	figure	figure	NOUN
admet-916	163	20	3	3	NUM
admet-916	163	21	)	)	PUNCT
admet-916	163	22	.	.	PUNCT
admet-916	164	1	the	the	DET
admet-916	164	2	recovery	recovery	NOUN
admet-916	164	3	value	value	NOUN
admet-916	164	4	of	of	ADP
admet-916	164	5	r	r	NOUN
admet-916	164	6	=	=	SYM
admet-916	164	7	96.19	96.19	NUM
admet-916	164	8	%	%	NOUN
admet-916	164	9	(	(	PUNCT
admet-916	164	10	table	table	NOUN
admet-916	164	11	3	3	NUM
admet-916	164	12	)	)	PUNCT
admet-916	164	13	indicates	indicate	VERB
admet-916	164	14	that	that	SCONJ
admet-916	164	15	metformin	metformin	NOUN
admet-916	164	16	mostly	mostly	ADV
admet-916	164	17	uninterruptedly	uninterruptedly	ADV
admet-916	164	18	permeated	permeate	VERB
admet-916	164	19	.	.	PUNCT
admet-916	165	1	in	in	ADP
admet-916	165	2	summary	summary	NOUN
admet-916	165	3	,	,	PUNCT
admet-916	165	4	metformin	metformin	NOUN
admet-916	165	5	is	be	AUX
admet-916	165	6	highly	highly	ADV
admet-916	165	7	ionized	ionized	ADJ
admet-916	165	8	throughout	throughout	ADP
admet-916	165	9	the	the	DET
admet-916	165	10	length	length	NOUN
admet-916	165	11	of	of	ADP
admet-916	165	12	the	the	DET
admet-916	165	13	git	git	NOUN
admet-916	165	14	,	,	PUNCT
admet-916	165	15	which	which	PRON
admet-916	165	16	explains	explain	VERB
admet-916	165	17	its	its	PRON
admet-916	165	18	low	low	ADJ
admet-916	165	19	permeability	permeability	NOUN
admet-916	165	20	by	by	ADP
admet-916	165	21	passive	passive	ADJ
admet-916	165	22	transport	transport	NOUN
admet-916	165	23	.	.	PUNCT
admet-916	166	1	it	it	PRON
admet-916	166	2	also	also	ADV
admet-916	166	3	explains	explain	VERB
admet-916	166	4	the	the	DET
admet-916	166	5	fact	fact	NOUN
admet-916	166	6	that	that	SCONJ
admet-916	166	7	metformin	metformin	NOUN
admet-916	166	8	is	be	AUX
admet-916	166	9	in	in	ADP
admet-916	166	10	bcs	bcs	NOUN
admet-916	166	11	class	class	NOUN
admet-916	166	12	iii	iii	PROPN
admet-916	166	13	(	(	PUNCT
admet-916	166	14	high	high	ADJ
admet-916	166	15	solubility	solubility	NOUN
admet-916	166	16	low	low	ADJ
admet-916	166	17	permeability	permeability	NOUN
admet-916	166	18	)	)	PUNCT
admet-916	166	19	.	.	PUNCT
admet-916	167	1	its	its	PRON
admet-916	167	2	permeability	permeability	NOUN
admet-916	167	3	,	,	PUNCT
admet-916	167	4	as	as	SCONJ
admet-916	167	5	mentioned	mention	VERB
admet-916	167	6	earlier	early	ADV
admet-916	167	7	,	,	PUNCT
admet-916	167	8	is	be	AUX
admet-916	167	9	significantly	significantly	ADV
admet-916	167	10	higher	high	ADJ
admet-916	167	11	in	in	ADP
admet-916	167	12	vivo	vivo	NOUN
admet-916	167	13	,	,	PUNCT
admet-916	167	14	since	since	SCONJ
admet-916	167	15	it	it	PRON
admet-916	167	16	is	be	AUX
admet-916	167	17	suggested	suggest	VERB
admet-916	167	18	to	to	PART
admet-916	167	19	be	be	AUX
admet-916	167	20	absorbed	absorb	VERB
admet-916	167	21	by	by	ADP
admet-916	167	22	active	active	ADJ
admet-916	167	23	transport	transport	NOUN
admet-916	167	24	through	through	ADP
admet-916	167	25	supported	support	VERB
admet-916	167	26	carriers	carrier	NOUN
admet-916	167	27	[	[	X
admet-916	167	28	22	22	NUM
admet-916	167	29	]	]	PUNCT
admet-916	167	30	.	.	PUNCT
admet-916	168	1	in	in	ADP
admet-916	168	2	figure	figure	NOUN
admet-916	168	3	3	3	NUM
admet-916	168	4	,	,	PUNCT
admet-916	168	5	it	it	PRON
admet-916	168	6	can	can	AUX
admet-916	168	7	be	be	AUX
admet-916	168	8	seen	see	VERB
admet-916	168	9	that	that	SCONJ
admet-916	168	10	as	as	ADP
admet-916	168	11	the	the	DET
admet-916	168	12	ph	ph	NOUN
admet-916	168	13	value	value	NOUN
admet-916	168	14	increases	increase	NOUN
admet-916	168	15	,	,	PUNCT
admet-916	168	16	the	the	DET
admet-916	168	17	slopes	slope	NOUN
admet-916	168	18	of	of	ADP
admet-916	168	19	the	the	DET
admet-916	168	20	metformin	metformin	NOUN
admet-916	168	21	permeation	permeation	NOUN
admet-916	168	22	profile	profile	NOUN
admet-916	168	23	increase	increase	NOUN
admet-916	168	24	,	,	PUNCT
admet-916	168	25	so	so	CCONJ
admet-916	168	26	the	the	DET
admet-916	168	27	highest	high	ADJ
admet-916	168	28	papp	papp	NOUN
admet-916	168	29	values	value	NOUN
admet-916	168	30	were	be	AUX
admet-916	168	31	observed	observe	VERB
admet-916	168	32	at	at	ADP
admet-916	168	33	ph	ph	PROPN
admet-916	168	34	7.4	7.4	NUM
admet-916	168	35	.	.	PUNCT
admet-916	169	1	at	at	ADP
admet-916	169	2	this	this	DET
admet-916	169	3	ph	ph	ADJ
admet-916	169	4	value	value	NOUN
admet-916	169	5	,	,	PUNCT
admet-916	169	6	metformin	metformin	NOUN
admet-916	169	7	has	have	VERB
admet-916	169	8	good	good	ADJ
admet-916	169	9	solubility	solubility	NOUN
admet-916	169	10	,	,	PUNCT
admet-916	169	11	low	low	ADJ
admet-916	169	12	lipophilicity	lipophilicity	NOUN
admet-916	169	13	,	,	PUNCT
admet-916	169	14	and	and	CCONJ
admet-916	169	15	the	the	DET
admet-916	169	16	highest	high	ADJ
admet-916	169	17	concentration	concentration	NOUN
admet-916	169	18	of	of	ADP
admet-916	169	19	non	non	ADJ
admet-916	169	20	-	-	ADJ
admet-916	169	21	ionized	ionized	ADJ
admet-916	169	22	substance	substance	NOUN
admet-916	169	23	compared	compare	VERB
admet-916	169	24	to	to	ADP
admet-916	169	25	the	the	DET
admet-916	169	26	other	other	ADJ
admet-916	169	27	studied	study	VERB
admet-916	169	28	ph	ph	ADJ
admet-916	169	29	values	value	NOUN
admet-916	169	30	,	,	PUNCT
admet-916	169	31	thus	thus	ADV
admet-916	169	32	it	it	PRON
admet-916	169	33	more	more	ADV
admet-916	169	34	easily	easily	ADV
admet-916	169	35	permeates	permeate	VERB
admet-916	169	36	into	into	ADP
admet-916	169	37	the	the	DET
admet-916	169	38	acceptor	acceptor	NOUN
admet-916	169	39	compartment	compartment	NOUN
admet-916	169	40	with	with	ADP
admet-916	169	41	very	very	ADV
admet-916	169	42	small	small	ADJ
admet-916	169	43	percentage	percentage	NOUN
admet-916	169	44	of	of	ADP
admet-916	169	45	retention	retention	NOUN
admet-916	169	46	in	in	ADP
admet-916	169	47	the	the	DET
admet-916	169	48	artificial	artificial	ADJ
admet-916	169	49	membrane	membrane	NOUN
admet-916	169	50	.	.	PUNCT
admet-916	170	1	the	the	DET
admet-916	170	2	log	log	NOUN
admet-916	170	3	d	d	NOUN
admet-916	170	4	value	value	NOUN
admet-916	170	5	for	for	ADP
admet-916	170	6	metformin	metformin	NOUN
admet-916	170	7	is	be	AUX
admet-916	170	8	-1.43	-1.43	NUM
admet-916	170	9	,	,	PUNCT
admet-916	170	10	which	which	PRON
admet-916	170	11	indicates	indicate	VERB
admet-916	170	12	low	low	ADJ
admet-916	170	13	solubility	solubility	NOUN
admet-916	170	14	in	in	ADP
admet-916	170	15	lipids	lipid	NOUN
admet-916	170	16	,	,	PUNCT
admet-916	170	17	and	and	CCONJ
admet-916	170	18	thus	thus	ADV
admet-916	170	19	low	low	ADJ
admet-916	170	20	affinity	affinity	NOUN
admet-916	170	21	for	for	ADP
admet-916	170	22	the	the	DET
admet-916	170	23	membrane	membrane	NOUN
admet-916	170	24	,	,	PUNCT
admet-916	170	25	which	which	PRON
admet-916	170	26	is	be	AUX
admet-916	170	27	lipid	lipid	NOUN
admet-916	170	28	in	in	ADP
admet-916	170	29	nature	nature	NOUN
admet-916	170	30	.	.	PUNCT
admet-916	171	1	as	as	SCONJ
admet-916	171	2	can	can	AUX
admet-916	171	3	be	be	AUX
admet-916	171	4	seen	see	VERB
admet-916	171	5	from	from	ADP
admet-916	171	6	figure	figure	NOUN
admet-916	171	7	3	3	NUM
admet-916	171	8	,	,	PUNCT
admet-916	171	9	after	after	ADP
admet-916	171	10	the	the	DET
admet-916	171	11	initial	initial	ADJ
admet-916	171	12	jump	jump	NOUN
admet-916	171	13	in	in	ADP
admet-916	171	14	the	the	DET
admet-916	171	15	concentration	concentration	NOUN
admet-916	171	16	of	of	ADP
admet-916	171	17	permeated	permeate	VERB
admet-916	171	18	metformin	metformin	NOUN
admet-916	171	19	after	after	ADP
admet-916	171	20	30	30	NUM
admet-916	171	21	minutes	minute	NOUN
admet-916	171	22	at	at	ADP
admet-916	171	23	ph	ph	PROPN
admet-916	171	24	2.0	2.0	NUM
admet-916	171	25	,	,	PUNCT
admet-916	171	26	almost	almost	ADV
admet-916	171	27	a	a	DET
admet-916	171	28	plateau	plateau	NOUN
admet-916	171	29	is	be	AUX
admet-916	171	30	reached	reach	VERB
admet-916	171	31	,	,	PUNCT
admet-916	171	32	which	which	PRON
admet-916	171	33	can	can	AUX
admet-916	171	34	be	be	AUX
admet-916	171	35	explained	explain	VERB
admet-916	171	36	in	in	ADP
admet-916	171	37	that	that	SCONJ
admet-916	171	38	the	the	DET
admet-916	171	39	saturation	saturation	NOUN
admet-916	171	40	of	of	ADP
admet-916	171	41	metformin	metformin	NOUN
admet-916	171	42	in	in	ADP
admet-916	171	43	the	the	DET
admet-916	171	44	membrane	membrane	NOUN
admet-916	171	45	is	be	AUX
admet-916	171	46	reached	reach	VERB
admet-916	171	47	and	and	CCONJ
admet-916	171	48	diprotonated	diprotonate	VERB
admet-916	171	49	molecules	molecule	NOUN
admet-916	171	50	repel	repel	VERB
admet-916	171	51	each	each	DET
admet-916	171	52	other	other	ADJ
admet-916	171	53	impeding	impede	VERB
admet-916	171	54	further	further	ADJ
admet-916	171	55	permeation	permeation	NOUN
admet-916	171	56	through	through	ADP
admet-916	171	57	the	the	DET
admet-916	171	58	membrane	membrane	NOUN
admet-916	171	59	.	.	PUNCT
admet-916	172	1	this	this	PRON
admet-916	172	2	is	be	AUX
admet-916	172	3	similar	similar	ADJ
admet-916	172	4	,	,	PUNCT
admet-916	172	5	although	although	SCONJ
admet-916	172	6	less	less	ADV
admet-916	172	7	pronounced	pronounce	VERB
admet-916	172	8	,	,	PUNCT
admet-916	172	9	at	at	ADP
admet-916	172	10	higher	high	ADJ
admet-916	172	11	ph	ph	ADJ
admet-916	172	12	values	value	NOUN
admet-916	172	13	.	.	PUNCT
admet-916	173	1	the	the	DET
admet-916	173	2	behavior	behavior	NOUN
admet-916	173	3	of	of	ADP
admet-916	173	4	metformin	metformin	NOUN
admet-916	173	5	at	at	ADP
admet-916	173	6	ph	ph	ADJ
admet-916	173	7	values	value	NOUN
admet-916	173	8	of	of	ADP
admet-916	173	9	6.8	6.8	NUM
admet-916	173	10	and	and	CCONJ
admet-916	173	11	4.5	4.5	NUM
admet-916	173	12	corresponding	correspond	VERB
admet-916	173	13	to	to	ADP
admet-916	173	14	the	the	DET
admet-916	173	15	small	small	ADJ
admet-916	173	16	intestine	intestine	NOUN
admet-916	173	17	was	be	AUX
admet-916	173	18	shown	show	VERB
admet-916	173	19	to	to	PART
admet-916	173	20	be	be	AUX
admet-916	173	21	very	very	ADV
admet-916	173	22	similar	similar	ADJ
admet-916	173	23	(	(	PUNCT
admet-916	173	24	figure	figure	NOUN
admet-916	173	25	3	3	NUM
admet-916	173	26	)	)	PUNCT
admet-916	173	27	.	.	PUNCT
admet-916	174	1	even	even	ADV
admet-916	174	2	though	though	SCONJ
admet-916	174	3	low	low	ADJ
admet-916	174	4	permeation	permeation	NOUN
admet-916	174	5	rates	rate	NOUN
admet-916	174	6	were	be	AUX
admet-916	174	7	observed	observe	VERB
admet-916	174	8	at	at	ADP
admet-916	174	9	both	both	DET
admet-916	174	10	ph	ph	ADJ
admet-916	174	11	values	value	NOUN
admet-916	174	12	,	,	PUNCT
admet-916	174	13	permeation	permeation	NOUN
admet-916	174	14	of	of	ADP
admet-916	174	15	metformin	metformin	NOUN
admet-916	174	16	at	at	ADP
admet-916	174	17	ph	ph	PROPN
admet-916	174	18	4.5	4.5	NUM
admet-916	174	19	physiologically	physiologically	ADV
admet-916	174	20	present	present	ADJ
admet-916	174	21	in	in	ADP
admet-916	174	22	the	the	DET
admet-916	174	23	duodenum	duodenum	NOUN
admet-916	174	24	showed	show	VERB
admet-916	174	25	a	a	DET
admet-916	174	26	slight	slight	NOUN
admet-916	174	27	,	,	PUNCT
admet-916	174	28	although	although	SCONJ
admet-916	174	29	insignificant	insignificant	ADJ
admet-916	174	30	,	,	PUNCT
admet-916	174	31	advantage	advantage	NOUN
admet-916	174	32	.	.	PUNCT
admet-916	175	1	in	in	ADP
admet-916	175	2	humans	human	NOUN
admet-916	175	3	,	,	PUNCT
admet-916	175	4	metformin	metformin	NOUN
admet-916	175	5	absorption	absorption	NOUN
admet-916	175	6	is	be	AUX
admet-916	175	7	incomplete	incomplete	ADJ
admet-916	175	8	and	and	CCONJ
admet-916	175	9	bioavailability	bioavailability	NOUN
admet-916	175	10	shows	show	VERB
admet-916	175	11	interindividual	interindividual	ADJ
admet-916	175	12	variability	variability	NOUN
admet-916	175	13	at	at	ADP
admet-916	175	14	55	55	NUM
admet-916	175	15	±	±	NUM
admet-916	175	16	16	16	NUM
admet-916	175	17	%	%	NOUN
admet-916	175	18	.	.	PUNCT
admet-916	176	1	absorption	absorption	NOUN
admet-916	176	2	ceases	cease	VERB
admet-916	176	3	6	6	NUM
admet-916	176	4	10	10	NUM
admet-916	176	5	hours	hour	NOUN
admet-916	176	6	after	after	ADP
admet-916	176	7	administration	administration	NOUN
admet-916	176	8	,	,	PUNCT
admet-916	176	9	regardless	regardless	ADV
admet-916	176	10	of	of	ADP
admet-916	176	11	the	the	DET
admet-916	176	12	amount	amount	NOUN
admet-916	176	13	of	of	ADP
admet-916	176	14	metformin	metformin	NOUN
admet-916	176	15	administered	administer	VERB
admet-916	176	16	,	,	PUNCT
admet-916	176	17	which	which	PRON
admet-916	176	18	is	be	AUX
admet-916	176	19	approximately	approximately	ADV
admet-916	176	20	the	the	DET
admet-916	176	21	time	time	NOUN
admet-916	176	22	of	of	ADP
admet-916	176	23	passage	passage	NOUN
admet-916	176	24	of	of	ADP
admet-916	176	25	the	the	DET
admet-916	176	26	drug	drug	NOUN
admet-916	176	27	through	through	ADP
admet-916	176	28	the	the	DET
admet-916	176	29	stomach	stomach	NOUN
admet-916	176	30	and	and	CCONJ
admet-916	176	31	small	small	ADJ
admet-916	176	32	intestine	intestine	NOUN
admet-916	177	1	[	[	X
admet-916	177	2	27	27	NUM
admet-916	177	3	]	]	PUNCT
admet-916	177	4	.	.	PUNCT
admet-916	178	1	human	human	ADJ
admet-916	178	2	data	datum	NOUN
admet-916	178	3	are	be	AUX
admet-916	178	4	lacking	lack	VERB
admet-916	178	5	in	in	ADP
admet-916	178	6	ph	ph	ADJ
admet-916	178	7	dependent	dependent	ADJ
admet-916	178	8	transport	transport	NOUN
admet-916	178	9	across	across	ADP
admet-916	178	10	the	the	DET
admet-916	178	11	git	git	NOUN
admet-916	178	12	membranes	membrane	NOUN
admet-916	178	13	,	,	PUNCT
admet-916	178	14	and	and	CCONJ
admet-916	178	15	thus	thus	ADV
admet-916	178	16	can	can	AUX
admet-916	178	17	not	not	PART
admet-916	178	18	be	be	AUX
admet-916	178	19	further	far	ADV
admet-916	178	20	discussed	discuss	VERB
admet-916	178	21	.	.	PUNCT
admet-916	179	1	lassoued	lassoue	VERB
admet-916	179	2	et	et	PROPN
admet-916	179	3	al	al	PROPN
admet-916	179	4	.	.	PUNCT
admet-916	180	1	[	[	X
admet-916	180	2	23	23	NUM
admet-916	180	3	]	]	PUNCT
admet-916	180	4	in	in	ADP
admet-916	180	5	their	their	PRON
admet-916	180	6	comparative	comparative	ADJ
admet-916	180	7	study	study	NOUN
admet-916	180	8	of	of	ADP
admet-916	180	9	permeation	permeation	NOUN
admet-916	180	10	of	of	ADP
admet-916	180	11	metformin	metformin	NOUN
admet-916	180	12	by	by	ADP
admet-916	180	13	the	the	DET
admet-916	180	14	sartorius	sartorius	NOUN
admet-916	180	15	sm	sm	PROPN
admet-916	180	16	16750	16750	NUM
admet-916	180	17	absorption	absorption	NOUN
admet-916	180	18	simulator	simulator	NOUN
admet-916	180	19	model	model	NOUN
admet-916	180	20	and	and	CCONJ
admet-916	180	21	inverted	inverted	ADJ
admet-916	180	22	sac	sac	NOUN
admet-916	180	23	technique	technique	NOUN
admet-916	180	24	showed	show	VERB
admet-916	180	25	a	a	DET
admet-916	180	26	good	good	ADJ
admet-916	180	27	correlation	correlation	NOUN
admet-916	180	28	in	in	ADP
admet-916	180	29	the	the	DET
admet-916	180	30	determination	determination	NOUN
admet-916	180	31	of	of	ADP
admet-916	180	32	metformin	metformin	NOUN
admet-916	180	33	permeability	permeability	NOUN
admet-916	180	34	.	.	PUNCT
admet-916	181	1	the	the	DET
admet-916	181	2	results	result	NOUN
admet-916	181	3	of	of	ADP
admet-916	181	4	the	the	DET
admet-916	181	5	study	study	NOUN
admet-916	181	6	conducted	conduct	VERB
admet-916	181	7	by	by	ADP
admet-916	181	8	song	song	NOUN
admet-916	181	9	et	et	PROPN
admet-916	181	10	al	al	PROPN
admet-916	181	11	.	.	PUNCT
admet-916	182	1	[	[	X
admet-916	182	2	24	24	NUM
admet-916	182	3	]	]	PUNCT
admet-916	182	4	concluded	conclude	VERB
admet-916	182	5	that	that	SCONJ
admet-916	182	6	metformin	metformin	NOUN
admet-916	182	7	is	be	AUX
admet-916	182	8	transported	transport	VERB
admet-916	182	9	via	via	ADP
admet-916	182	10	saturable	saturable	ADJ
admet-916	182	11	carriers	carrier	NOUN
admet-916	182	12	.	.	PUNCT
admet-916	183	1	the	the	DET
admet-916	183	2	results	result	NOUN
admet-916	183	3	were	be	AUX
admet-916	183	4	not	not	PART
admet-916	183	5	correlated	correlate	VERB
admet-916	183	6	with	with	ADP
admet-916	183	7	dynamic	dynamic	ADJ
admet-916	183	8	diffusion	diffusion	NOUN
admet-916	183	9	cell	cell	NOUN
admet-916	183	10	model	model	NOUN
admet-916	183	11	due	due	ADP
admet-916	183	12	to	to	ADP
admet-916	183	13	the	the	DET
admet-916	183	14	difference	difference	NOUN
admet-916	183	15	in	in	ADP
admet-916	183	16	the	the	DET
admet-916	183	17	used	use	VERB
admet-916	183	18	methods	method	NOUN
admet-916	183	19	.	.	PUNCT
admet-916	184	1	http://dx.doi.org/10.5599/admet.916	http://dx.doi.org/10.5599/admet.916	PROPN
admet-916	184	2	alisa	alisa	PROPN
admet-916	184	3	elezović	elezović	PROPN
admet-916	184	4	et	et	PROPN
admet-916	184	5	al	al	PROPN
admet-916	184	6	.	.	PROPN
admet-916	184	7	admet	admet	PROPN
admet-916	184	8	&	&	CCONJ
admet-916	184	9	dmpk	dmpk	PROPN
admet-916	184	10	9(1	9(1	NUM
admet-916	184	11	)	)	PUNCT
admet-916	184	12	(	(	PUNCT
admet-916	184	13	2021	2021	NUM
admet-916	184	14	)	)	PUNCT
admet-916	184	15	57	57	NUM
admet-916	184	16	-	-	SYM
admet-916	184	17	68	68	NUM
admet-916	184	18	66	66	NUM
admet-916	184	19	table	table	NOUN
admet-916	184	20	4	4	NUM
admet-916	184	21	.	.	PUNCT
admet-916	184	22	experimentally	experimentally	ADV
admet-916	184	23	obtained	obtain	VERB
admet-916	184	24	apparent	apparent	ADJ
admet-916	184	25	permeation	permeation	NOUN
admet-916	184	26	coefficients	coefficient	NOUN
admet-916	184	27	(	(	PUNCT
admet-916	184	28	cm	cm	NOUN
admet-916	184	29	s	s	PART
admet-916	184	30	-1	-1	PUNCT
admet-916	184	31	)	)	PUNCT
admet-916	184	32	of	of	ADP
admet-916	184	33	metformin	metformin	NOUN
admet-916	184	34	at	at	ADP
admet-916	184	35	different	different	ADJ
admet-916	184	36	ph	ph	ADJ
admet-916	184	37	values	value	NOUN
admet-916	184	38	and	and	CCONJ
admet-916	184	39	literature	literature	NOUN
admet-916	184	40	data	datum	NOUN
admet-916	184	41	obtained	obtain	VERB
admet-916	184	42	by	by	ADP
admet-916	184	43	other	other	ADJ
admet-916	184	44	methods	method	NOUN
admet-916	184	45	.	.	PUNCT
admet-916	185	1	ph	ph	PROPN
admet-916	185	2	papp	papp	PROPN
admet-916	185	3	±	±	PROPN
admet-916	185	4	sd	sd	PROPN
admet-916	185	5	(	(	PUNCT
admet-916	185	6	×10	×10	PROPN
admet-916	185	7	-6	-6	PROPN
admet-916	185	8	)	)	PUNCT
admet-916	185	9	papp±	papp±	PROPN
admet-916	185	10	sd	sd	ADP
admet-916	185	11	a	a	DET
admet-916	185	12	(	(	PUNCT
admet-916	185	13	×10	×10	PROPN
admet-916	185	14	-6	-6	PROPN
admet-916	185	15	)	)	PUNCT
admet-916	185	16	papp	papp	PROPN
admet-916	185	17	±	±	PROPN
admet-916	185	18	sd	sd	ADP
admet-916	185	19	a	a	DET
admet-916	185	20	(	(	PUNCT
admet-916	185	21	×10	×10	PROPN
admet-916	185	22	-6	-6	PROPN
admet-916	185	23	)	)	PUNCT
admet-916	185	24	papp	papp	PROPN
admet-916	185	25	±	±	PROPN
admet-916	185	26	sd	sd	PROPN
admet-916	185	27	b	b	PROPN
admet-916	185	28	(	(	PUNCT
admet-916	185	29	×10	×10	PROPN
admet-916	185	30	-6	-6	PROPN
admet-916	185	31	)	)	PUNCT
admet-916	185	32	papp	papp	PROPN
admet-916	185	33	±	±	PROPN
admet-916	185	34	sd	sd	PROPN
admet-916	185	35	b	b	PROPN
admet-916	185	36	(	(	PUNCT
admet-916	185	37	×10	×10	PROPN
admet-916	185	38	-6	-6	PROPN
admet-916	185	39	)	)	PUNCT
admet-916	185	40	peff	peff	PROPN
admet-916	185	41	±	±	NUM
admet-916	185	42	sd	sd	ADP
admet-916	185	43	c	c	PROPN
admet-916	185	44	(	(	PUNCT
admet-916	185	45	×10	×10	PROPN
admet-916	185	46	-6	-6	PROPN
admet-916	185	47	)	)	PUNCT
admet-916	185	48	log	log	NOUN
admet-916	186	1	d	d	PROPN
admet-916	186	2	d	d	X
admet-916	186	3	papp	papp	PROPN
admet-916	186	4	d	d	PROPN
admet-916	186	5	(	(	PUNCT
admet-916	186	6	×10	×10	PROPN
admet-916	186	7	-6	-6	NOUN
admet-916	186	8	)	)	PUNCT
admet-916	186	9	papp	papp	PROPN
admet-916	186	10	±	±	PROPN
admet-916	186	11	sd	sd	ADP
admet-916	186	12	e	e	PROPN
admet-916	186	13	(	(	PUNCT
admet-916	186	14	×10	×10	PROPN
admet-916	186	15	-6	-6	PROPN
admet-916	186	16	)	)	PUNCT
admet-916	186	17	2.0	2.0	NUM
admet-916	186	18	0.055±0.006	0.055±0.006	NUM
admet-916	186	19	/	/	SYM
admet-916	186	20	/	/	SYM
admet-916	186	21	/	/	SYM
admet-916	186	22	/	/	SYM
admet-916	186	23	/	/	SYM
admet-916	186	24	/	/	SYM
admet-916	186	25	/	/	SYM
admet-916	186	26	/	/	SYM
admet-916	186	27	4.5	4.5	NUM
admet-916	186	28	0.098±0.002	0.098±0.002	NOUN
admet-916	186	29	/	/	SYM
admet-916	186	30	/	/	SYM
admet-916	186	31	/	/	SYM
admet-916	186	32	/	/	SYM
admet-916	186	33	45.1±10.8	45.1±10.8	PROPN
admet-916	186	34	(	(	PUNCT
admet-916	186	35	duodenum	duodenum	ADJ
admet-916	186	36	)	)	PUNCT
admet-916	186	37	-1.41	-1.41	NOUN
admet-916	186	38	/	/	SYM
admet-916	186	39	/	/	SYM
admet-916	186	40	6.8	6.8	NUM
admet-916	186	41	0.098±0.002	0.098±0.002	NOUN
admet-916	186	42	v	v	ADP
admet-916	186	43	0.74±0.15	0.74±0.15	PROPN
admet-916	186	44	s	s	PART
admet-916	186	45	0.61±0.1	0.61±0.1	NUM
admet-916	186	46	/	/	SYM
admet-916	186	47	/	/	SYM
admet-916	186	48	32.6±7.3	32.6±7.3	NUM
admet-916	186	49	(	(	PUNCT
admet-916	186	50	jejunum	jejunum	PROPN
admet-916	186	51	)	)	PUNCT
admet-916	186	52	29.6	29.6	NUM
admet-916	186	53	±	±	NUM
admet-916	186	54	3.6	3.6	NUM
admet-916	186	55	(	(	PUNCT
admet-916	186	56	ileum	ileum	NOUN
admet-916	186	57	)	)	PUNCT
admet-916	186	58	-1.30	-1.30	VERB
admet-916	186	59	-1.31	-1.31	PROPN
admet-916	186	60	/	/	SYM
admet-916	186	61	0.50±0.057	0.50±0.057	PROPN
admet-916	186	62	7.4	7.4	NUM
admet-916	186	63	0.298±0.011	0.298±0.011	NOUN
admet-916	186	64	/	/	PUNCT
admet-916	186	65	/	/	PUNCT
admet-916	186	66	a	a	PRON
admet-916	186	67	8.6±1.4	8.6±1.4	NUM
admet-916	186	68	b	b	NOUN
admet-916	186	69	10.9±1.9	10.9±1.9	NUM
admet-916	186	70	/	/	SYM
admet-916	186	71	-1.23	-1.23	NUM
admet-916	186	72	5.5	5.5	NUM
admet-916	186	73	/	/	SYM
admet-916	186	74	a	a	DET
admet-916	186	75	values	value	NOUN
admet-916	186	76	papp	papp	NOUN
admet-916	186	77	obtained	obtain	VERB
admet-916	186	78	by	by	ADP
admet-916	186	79	inverted	inverted	ADJ
admet-916	186	80	sac	sac	NOUN
admet-916	186	81	and	and	CCONJ
admet-916	186	82	sartorius	sartorius	NOUN
admet-916	186	83	model	model	NOUN
admet-916	186	84	[	[	X
admet-916	186	85	23	23	NUM
admet-916	186	86	]	]	PUNCT
admet-916	186	87	;	;	PUNCT
admet-916	186	88	b	b	X
admet-916	186	89	values	value	NOUN
admet-916	186	90	papp	papp	NOUN
admet-916	186	91	obtained	obtain	VERB
admet-916	186	92	on	on	ADP
admet-916	186	93	the	the	DET
admet-916	186	94	same	same	ADJ
admet-916	186	95	sartorius	sartorius	NOUN
admet-916	186	96	model	model	NOUN
admet-916	186	97	with	with	ADP
admet-916	186	98	the	the	DET
admet-916	186	99	same	same	ADJ
admet-916	186	100	experimental	experimental	ADJ
admet-916	186	101	conditions	condition	NOUN
admet-916	186	102	with	with	ADP
admet-916	186	103	impregnation	impregnation	NOUN
admet-916	186	104	solution	solution	NOUN
admet-916	186	105	variation	variation	NOUN
admet-916	186	106	[	[	X
admet-916	186	107	16	16	NUM
admet-916	186	108	]	]	PUNCT
admet-916	186	109	;	;	PUNCT
admet-916	186	110	c	c	PROPN
admet-916	186	111	values	value	NOUN
admet-916	186	112	papp	papp	NOUN
admet-916	186	113	obtained	obtain	VERB
admet-916	186	114	on	on	ADP
admet-916	186	115	isolated	isolated	ADJ
admet-916	186	116	duodenum	duodenum	ADJ
admet-916	186	117	,	,	PUNCT
admet-916	186	118	jejunum	jejunum	ADJ
admet-916	186	119	and	and	CCONJ
admet-916	186	120	ileum	ileum	NOUN
admet-916	186	121	segments	segment	NOUN
admet-916	186	122	in	in	ADP
admet-916	186	123	caco-2	caco-2	NUM
admet-916	186	124	cell	cell	NOUN
admet-916	186	125	model	model	NOUN
admet-916	186	126	[	[	X
admet-916	186	127	24	24	NUM
admet-916	186	128	]	]	PUNCT
admet-916	186	129	;	;	PUNCT
admet-916	186	130	d	d	X
admet-916	186	131	values	value	NOUN
admet-916	186	132	log	log	VERB
admet-916	186	133	d	d	NOUN
admet-916	186	134	and	and	CCONJ
admet-916	186	135	papp	papp	NOUN
admet-916	186	136	obtained	obtain	VERB
admet-916	186	137	by	by	ADP
admet-916	186	138	caco-2	caco-2	NUM
admet-916	186	139	cell	cell	NOUN
admet-916	186	140	model	model	NOUN
admet-916	187	1	[	[	X
admet-916	187	2	25	25	NUM
admet-916	187	3	]	]	PUNCT
admet-916	187	4	;	;	PUNCT
admet-916	188	1	e	e	X
admet-916	188	2	values	value	NOUN
admet-916	188	3	papp	papp	NOUN
admet-916	188	4	obtained	obtain	VERB
admet-916	188	5	by	by	ADP
admet-916	188	6	caco-2	caco-2	NUM
admet-916	188	7	cell	cell	NOUN
admet-916	188	8	model	model	NOUN
admet-916	188	9	[	[	X
admet-916	188	10	26	26	NUM
admet-916	188	11	]	]	PUNCT
admet-916	188	12	however	however	ADV
admet-916	188	13	,	,	PUNCT
admet-916	188	14	in	in	ADP
admet-916	188	15	the	the	DET
admet-916	188	16	study	study	NOUN
admet-916	188	17	conducted	conduct	VERB
admet-916	188	18	by	by	ADP
admet-916	188	19	nicklin	nicklin	PROPN
admet-916	188	20	et	et	PROPN
admet-916	188	21	al	al	PROPN
admet-916	188	22	.	.	PUNCT
admet-916	188	23	using	use	VERB
admet-916	188	24	the	the	DET
admet-916	188	25	caco-2	caco-2	NUM
admet-916	188	26	model	model	NOUN
admet-916	188	27	it	it	PRON
admet-916	188	28	was	be	AUX
admet-916	188	29	concluded	conclude	VERB
admet-916	188	30	that	that	SCONJ
admet-916	188	31	metformin	metformin	NOUN
admet-916	188	32	is	be	AUX
admet-916	188	33	transported	transport	VERB
admet-916	188	34	in	in	ADP
admet-916	188	35	the	the	DET
admet-916	188	36	caco-2	caco-2	NUM
admet-916	188	37	monolayer	monolayer	NOUN
admet-916	188	38	by	by	ADP
admet-916	188	39	passive	passive	ADJ
admet-916	188	40	,	,	PUNCT
admet-916	188	41	unsaturable	unsaturable	ADJ
admet-916	188	42	transport	transport	NOUN
admet-916	189	1	[	[	X
admet-916	189	2	25	25	NUM
admet-916	189	3	]	]	PUNCT
admet-916	189	4	.	.	PUNCT
admet-916	190	1	the	the	DET
admet-916	190	2	hydrophilicity	hydrophilicity	NOUN
admet-916	190	3	and	and	CCONJ
admet-916	190	4	molecular	molecular	ADJ
admet-916	190	5	weight	weight	NOUN
admet-916	190	6	of	of	ADP
admet-916	190	7	metformin	metformin	NOUN
admet-916	190	8	determined	determine	VERB
admet-916	190	9	the	the	DET
admet-916	190	10	papp	papp	NOUN
admet-916	190	11	value	value	NOUN
admet-916	190	12	of	of	ADP
admet-916	190	13	5.5	5.5	NUM
admet-916	190	14	×	×	NOUN
admet-916	190	15	10	10	NUM
admet-916	190	16	-	-	SYM
admet-916	190	17	6	6	NUM
admet-916	190	18	cm	cm	NUM
admet-916	190	19	s-1	s-1	NOUN
admet-916	190	20	,	,	PUNCT
admet-916	190	21	which	which	PRON
admet-916	190	22	is	be	AUX
admet-916	190	23	comparable	comparable	ADJ
admet-916	190	24	with	with	ADP
admet-916	190	25	the	the	DET
admet-916	190	26	results	result	NOUN
admet-916	190	27	of	of	ADP
admet-916	190	28	other	other	ADJ
admet-916	190	29	hydrophilic	hydrophilic	ADJ
admet-916	190	30	high	high	ADJ
admet-916	190	31	molecular	molecular	ADJ
admet-916	190	32	weight	weight	NOUN
admet-916	190	33	compounds	compound	NOUN
admet-916	190	34	tested	test	VERB
admet-916	190	35	by	by	ADP
admet-916	190	36	the	the	DET
admet-916	190	37	caco-2	caco-2	NUM
admet-916	190	38	model	model	NOUN
admet-916	190	39	[	[	X
admet-916	190	40	28	28	NUM
admet-916	190	41	]	]	PUNCT
admet-916	190	42	,	,	PUNCT
admet-916	190	43	but	but	CCONJ
admet-916	190	44	also	also	ADV
admet-916	190	45	with	with	ADP
admet-916	190	46	the	the	DET
admet-916	190	47	results	result	NOUN
admet-916	190	48	obtained	obtain	VERB
admet-916	190	49	in	in	ADP
admet-916	190	50	this	this	DET
admet-916	190	51	experimental	experimental	ADJ
admet-916	190	52	work	work	NOUN
admet-916	190	53	at	at	ADP
admet-916	190	54	the	the	DET
admet-916	190	55	same	same	ADJ
admet-916	190	56	ph	ph	ADJ
admet-916	190	57	values	value	NOUN
admet-916	190	58	(	(	PUNCT
admet-916	190	59	table	table	NOUN
admet-916	190	60	4	4	NUM
admet-916	190	61	)	)	PUNCT
admet-916	190	62	.	.	PUNCT
admet-916	191	1	on	on	ADP
admet-916	191	2	the	the	DET
admet-916	191	3	other	other	ADJ
admet-916	191	4	hand	hand	NOUN
admet-916	191	5	,	,	PUNCT
admet-916	191	6	in	in	ADP
admet-916	191	7	the	the	DET
admet-916	191	8	caco-2	caco-2	NUM
admet-916	191	9	cell	cell	NOUN
admet-916	191	10	model	model	NOUN
admet-916	191	11	study	study	NOUN
admet-916	191	12	conducted	conduct	VERB
admet-916	191	13	by	by	ADP
admet-916	191	14	proctor	proctor	PROPN
admet-916	191	15	et	et	PROPN
admet-916	191	16	al	al	PROPN
admet-916	191	17	.	.	PUNCT
admet-916	192	1	[	[	X
admet-916	192	2	26	26	NUM
admet-916	192	3	]	]	PUNCT
admet-916	192	4	the	the	DET
admet-916	192	5	transport	transport	NOUN
admet-916	192	6	and	and	CCONJ
admet-916	192	7	absorption	absorption	NOUN
admet-916	192	8	of	of	ADP
admet-916	192	9	metformin	metformin	NOUN
admet-916	192	10	took	take	VERB
admet-916	192	11	place	place	NOUN
admet-916	192	12	via	via	ADP
admet-916	192	13	saturable	saturable	ADJ
admet-916	192	14	transport	transport	NOUN
admet-916	192	15	mechanisms	mechanism	NOUN
admet-916	192	16	.	.	PUNCT
admet-916	193	1	the	the	DET
admet-916	193	2	relative	relative	ADJ
admet-916	193	3	contribution	contribution	NOUN
admet-916	193	4	of	of	ADP
admet-916	193	5	transcellular	transcellular	NOUN
admet-916	193	6	and	and	CCONJ
admet-916	193	7	paracellular	paracellular	ADJ
admet-916	193	8	transport	transport	NOUN
admet-916	193	9	of	of	ADP
admet-916	193	10	metformin	metformin	NOUN
admet-916	193	11	at	at	ADP
admet-916	193	12	a	a	DET
admet-916	193	13	concentration	concentration	NOUN
admet-916	193	14	of	of	ADP
admet-916	193	15	0.05	0.05	NUM
admet-916	193	16	mm	mm	NOUN
admet-916	193	17	was	be	AUX
admet-916	193	18	estimated	estimate	VERB
admet-916	193	19	at	at	ADP
admet-916	193	20	9	9	NUM
admet-916	193	21	%	%	NOUN
admet-916	193	22	and	and	CCONJ
admet-916	193	23	91	91	NUM
admet-916	193	24	%	%	NOUN
admet-916	193	25	,	,	PUNCT
admet-916	193	26	respectively	respectively	ADV
admet-916	193	27	[	[	X
admet-916	193	28	26	26	NUM
admet-916	193	29	]	]	PUNCT
admet-916	193	30	.	.	PUNCT
admet-916	194	1	log	log	NOUN
admet-916	194	2	d	d	NOUN
admet-916	194	3	values	value	NOUN
admet-916	194	4	at	at	ADP
admet-916	194	5	the	the	DET
admet-916	194	6	studied	study	VERB
admet-916	194	7	ph	ph	NOUN
admet-916	194	8	were	be	AUX
admet-916	194	9	below	below	ADP
admet-916	194	10	0.5	0.5	NUM
admet-916	194	11	which	which	PRON
admet-916	194	12	implies	imply	VERB
admet-916	194	13	poor	poor	ADJ
admet-916	194	14	permeability	permeability	NOUN
admet-916	194	15	of	of	ADP
admet-916	194	16	metformin	metformin	NOUN
admet-916	194	17	within	within	ADP
admet-916	194	18	the	the	DET
admet-916	194	19	physiological	physiological	ADJ
admet-916	194	20	ph	ph	NOUN
admet-916	194	21	range	range	NOUN
admet-916	194	22	prevailing	prevail	VERB
admet-916	194	23	at	at	ADP
admet-916	194	24	the	the	DET
admet-916	194	25	git	git	NOUN
admet-916	194	26	level	level	NOUN
admet-916	194	27	,	,	PUNCT
admet-916	194	28	which	which	PRON
admet-916	194	29	is	be	AUX
admet-916	194	30	in	in	ADP
admet-916	194	31	line	line	NOUN
admet-916	194	32	with	with	ADP
admet-916	194	33	the	the	DET
admet-916	194	34	obtained	obtain	VERB
admet-916	194	35	results	result	NOUN
admet-916	194	36	.	.	PUNCT
admet-916	195	1	however	however	ADV
admet-916	195	2	,	,	PUNCT
admet-916	195	3	the	the	DET
admet-916	195	4	correlation	correlation	NOUN
admet-916	195	5	of	of	ADP
admet-916	195	6	the	the	DET
admet-916	195	7	results	result	NOUN
admet-916	195	8	with	with	ADP
admet-916	195	9	the	the	DET
admet-916	195	10	available	available	ADJ
admet-916	195	11	log	log	NOUN
admet-916	195	12	d	d	NOUN
admet-916	195	13	values	value	NOUN
admet-916	195	14	was	be	AUX
admet-916	195	15	very	very	ADV
admet-916	195	16	poor	poor	ADJ
admet-916	195	17	(	(	PUNCT
admet-916	195	18	r	r	NOUN
admet-916	195	19	2	2	NUM
admet-916	195	20	=	=	SYM
admet-916	195	21	0.63	0.63	NUM
admet-916	195	22	)	)	PUNCT
admet-916	195	23	.	.	PUNCT
admet-916	196	1	conclusions	conclusion	NOUN
admet-916	196	2	ketoprofen	ketoprofen	VERB
admet-916	196	3	is	be	AUX
admet-916	196	4	a	a	DET
admet-916	196	5	highly	highly	ADV
admet-916	196	6	permeable	permeable	ADJ
admet-916	196	7	acid	acid	NOUN
admet-916	196	8	,	,	PUNCT
admet-916	196	9	while	while	SCONJ
admet-916	196	10	metformin	metformin	NOUN
admet-916	196	11	is	be	AUX
admet-916	196	12	dibasic	dibasic	ADJ
admet-916	196	13	substance	substance	NOUN
admet-916	196	14	with	with	ADP
admet-916	196	15	low	low	ADJ
admet-916	196	16	permeability	permeability	NOUN
admet-916	196	17	.	.	PUNCT
admet-916	197	1	ph	ph	ADJ
admet-916	197	2	dependent	dependent	ADJ
admet-916	197	3	passive	passive	ADJ
admet-916	197	4	transport	transport	NOUN
admet-916	197	5	through	through	ADP
admet-916	197	6	an	an	DET
admet-916	197	7	artificial	artificial	ADJ
admet-916	197	8	biomimetic	biomimetic	ADJ
admet-916	197	9	membrane	membrane	NOUN
admet-916	197	10	of	of	ADP
admet-916	197	11	both	both	DET
admet-916	197	12	substances	substance	NOUN
admet-916	197	13	could	could	AUX
admet-916	197	14	be	be	AUX
admet-916	197	15	explained	explain	VERB
admet-916	197	16	by	by	ADP
admet-916	197	17	their	their	PRON
admet-916	197	18	ionization	ionization	NOUN
admet-916	197	19	properties	property	NOUN
admet-916	197	20	at	at	ADP
admet-916	197	21	studied	study	VERB
admet-916	197	22	ph	ph	ADJ
admet-916	197	23	values	value	NOUN
admet-916	197	24	of	of	ADP
admet-916	197	25	donor	donor	NOUN
admet-916	197	26	compartments	compartment	NOUN
admet-916	197	27	.	.	PUNCT
admet-916	198	1	log	log	VERB
admet-916	198	2	d	d	NOUN
admet-916	198	3	values	value	NOUN
admet-916	198	4	of	of	ADP
admet-916	198	5	ketoprofen	ketoprofen	NOUN
admet-916	198	6	correlated	correlate	VERB
admet-916	198	7	well	well	ADV
admet-916	198	8	,	,	PUNCT
admet-916	198	9	while	while	SCONJ
admet-916	198	10	those	those	PRON
admet-916	198	11	of	of	ADP
admet-916	198	12	metformin	metformin	NOUN
admet-916	198	13	did	do	VERB
admet-916	198	14	not	not	PART
admet-916	198	15	.	.	PUNCT
admet-916	199	1	the	the	DET
admet-916	199	2	literature	literature	NOUN
admet-916	199	3	accounts	account	NOUN
admet-916	199	4	of	of	ADP
admet-916	199	5	ph	ph	ADJ
admet-916	199	6	dependent	dependent	ADJ
admet-916	199	7	permeation	permeation	NOUN
admet-916	199	8	/	/	SYM
admet-916	199	9	absorption	absorption	NOUN
admet-916	199	10	are	be	AUX
admet-916	199	11	scarce	scarce	ADJ
admet-916	199	12	.	.	PUNCT
admet-916	200	1	however	however	ADV
admet-916	200	2	,	,	PUNCT
admet-916	200	3	when	when	SCONJ
admet-916	200	4	considering	consider	VERB
admet-916	200	5	those	those	PRON
admet-916	200	6	available	available	ADJ
admet-916	200	7	,	,	PUNCT
admet-916	200	8	the	the	DET
admet-916	200	9	results	result	NOUN
admet-916	200	10	correlated	correlate	VERB
admet-916	200	11	well	well	ADV
admet-916	200	12	with	with	ADP
admet-916	200	13	the	the	DET
admet-916	200	14	other	other	ADJ
admet-916	200	15	in	in	ADP
admet-916	200	16	vitro	vitro	X
admet-916	200	17	studies	study	NOUN
admet-916	200	18	.	.	PUNCT
admet-916	201	1	the	the	DET
admet-916	201	2	dynamic	dynamic	ADJ
admet-916	201	3	diffusion	diffusion	NOUN
admet-916	201	4	cell	cell	NOUN
admet-916	201	5	model	model	NOUN
admet-916	201	6	has	have	AUX
admet-916	201	7	proven	prove	VERB
admet-916	201	8	to	to	PART
admet-916	201	9	be	be	AUX
admet-916	201	10	an	an	DET
admet-916	201	11	efficient	efficient	ADJ
admet-916	201	12	,	,	PUNCT
admet-916	201	13	reproducible	reproducible	ADJ
admet-916	201	14	and	and	CCONJ
admet-916	201	15	simple	simple	ADJ
admet-916	201	16	method	method	NOUN
admet-916	201	17	for	for	ADP
admet-916	201	18	predicting	predict	VERB
admet-916	201	19	the	the	DET
admet-916	201	20	permeation	permeation	NOUN
admet-916	201	21	of	of	ADP
admet-916	201	22	ketoprofen	ketoprofen	NOUN
admet-916	201	23	.	.	PUNCT
admet-916	202	1	this	this	DET
admet-916	202	2	model	model	NOUN
admet-916	202	3	examines	examine	VERB
admet-916	202	4	passive	passive	ADJ
admet-916	202	5	transport	transport	NOUN
admet-916	202	6	across	across	ADP
admet-916	202	7	the	the	DET
admet-916	202	8	membrane	membrane	NOUN
admet-916	202	9	,	,	PUNCT
admet-916	202	10	and	and	CCONJ
admet-916	202	11	for	for	ADP
admet-916	202	12	substances	substance	NOUN
admet-916	202	13	that	that	PRON
admet-916	202	14	are	be	AUX
admet-916	202	15	absorbed	absorb	VERB
admet-916	202	16	by	by	ADP
admet-916	202	17	other	other	ADJ
admet-916	202	18	forms	form	NOUN
admet-916	202	19	of	of	ADP
admet-916	202	20	transport	transport	NOUN
admet-916	202	21	,	,	PUNCT
admet-916	202	22	such	such	ADJ
admet-916	202	23	as	as	ADP
admet-916	202	24	metformin	metformin	NOUN
admet-916	202	25	,	,	PUNCT
admet-916	202	26	this	this	DET
admet-916	202	27	method	method	NOUN
admet-916	202	28	can	can	AUX
admet-916	202	29	be	be	AUX
admet-916	202	30	used	use	VERB
admet-916	202	31	to	to	PART
admet-916	202	32	predict	predict	VERB
admet-916	202	33	only	only	ADV
admet-916	202	34	its	its	PRON
admet-916	202	35	passive	passive	ADJ
admet-916	202	36	transport	transport	NOUN
admet-916	202	37	component	component	NOUN
admet-916	202	38	.	.	PUNCT
admet-916	203	1	the	the	DET
admet-916	203	2	dynamic	dynamic	ADJ
admet-916	203	3	diffusion	diffusion	NOUN
admet-916	203	4	cell	cell	NOUN
admet-916	203	5	model	model	NOUN
admet-916	203	6	is	be	AUX
admet-916	203	7	a	a	DET
admet-916	203	8	good	good	ADJ
admet-916	203	9	foundation	foundation	NOUN
admet-916	203	10	for	for	ADP
admet-916	203	11	future	future	ADJ
admet-916	203	12	research	research	NOUN
admet-916	203	13	as	as	ADP
admet-916	203	14	a	a	DET
admet-916	203	15	valuable	valuable	ADJ
admet-916	203	16	resources	resource	NOUN
admet-916	203	17	-	-	PUNCT
admet-916	203	18	saving	save	VERB
admet-916	203	19	screening	screening	NOUN
admet-916	203	20	tool	tool	NOUN
admet-916	203	21	for	for	ADP
admet-916	203	22	the	the	DET
admet-916	203	23	new	new	ADJ
admet-916	203	24	drug	drug	NOUN
admet-916	203	25	candidates	candidate	NOUN
admet-916	203	26	at	at	ADP
admet-916	203	27	the	the	DET
admet-916	203	28	beginning	beginning	NOUN
admet-916	203	29	stages	stage	NOUN
admet-916	203	30	of	of	ADP
admet-916	203	31	their	their	PRON
admet-916	203	32	development	development	NOUN
admet-916	203	33	,	,	PUNCT
admet-916	203	34	as	as	ADV
admet-916	203	35	well	well	ADV
admet-916	203	36	as	as	ADP
admet-916	203	37	for	for	ADP
admet-916	203	38	known	know	VERB
admet-916	203	39	substances	substance	NOUN
admet-916	203	40	permeation	permeation	NOUN
admet-916	203	41	elucidation	elucidation	NOUN
admet-916	203	42	,	,	PUNCT
admet-916	203	43	especially	especially	ADV
admet-916	203	44	considering	consider	VERB
admet-916	203	45	its	its	PRON
admet-916	203	46	potential	potential	NOUN
admet-916	203	47	for	for	ADP
admet-916	203	48	testing	testing	NOUN
admet-916	203	49	at	at	ADP
admet-916	203	50	wide	wide	ADJ
admet-916	203	51	range	range	NOUN
admet-916	203	52	of	of	ADP
admet-916	203	53	ph	ph	ADJ
admet-916	203	54	conditions	condition	NOUN
admet-916	203	55	,	,	PUNCT
admet-916	203	56	which	which	PRON
admet-916	203	57	is	be	AUX
admet-916	203	58	very	very	ADV
admet-916	203	59	difficult	difficult	ADJ
admet-916	203	60	by	by	ADP
admet-916	203	61	other	other	ADJ
admet-916	203	62	methods	method	NOUN
admet-916	203	63	.	.	PUNCT
admet-916	204	1	admet	admet	PROPN
admet-916	204	2	&	&	CCONJ
admet-916	204	3	dmpk	dmpk	PROPN
admet-916	204	4	9(1	9(1	NUM
admet-916	204	5	)	)	PUNCT
admet-916	204	6	(	(	PUNCT
admet-916	204	7	2021	2021	NUM
admet-916	204	8	)	)	PUNCT
admet-916	204	9	57	57	NUM
admet-916	204	10	-	-	SYM
admet-916	204	11	68	68	NUM
admet-916	204	12	passive	passive	ADJ
admet-916	204	13	transport	transport	NOUN
admet-916	204	14	of	of	ADP
admet-916	204	15	ketoprofen	ketoprofen	NOUN
admet-916	204	16	and	and	CCONJ
admet-916	204	17	metformin	metformin	PROPN
admet-916	204	18	doi	doi	PROPN
admet-916	204	19	:	:	PUNCT
admet-916	204	20	http://dx.doi.org/10.5599/admet.916	http://dx.doi.org/10.5599/admet.916	PROPN
admet-916	204	21	67	67	NUM
admet-916	204	22	conflict	conflict	NOUN
admet-916	204	23	of	of	ADP
admet-916	204	24	interest	interest	NOUN
admet-916	204	25	:	:	PUNCT
admet-916	204	26	the	the	DET
admet-916	204	27	authors	author	NOUN
admet-916	204	28	declare	declare	VERB
admet-916	204	29	no	no	DET
admet-916	204	30	conflict	conflict	NOUN
admet-916	204	31	of	of	ADP
admet-916	204	32	interest	interest	NOUN
admet-916	204	33	.	.	PUNCT
admet-916	205	1	references	reference	NOUN
admet-916	205	2	[	[	X
admet-916	205	3	1	1	NUM
admet-916	205	4	]	]	X
admet-916	205	5	g.	g.	PROPN
admet-916	205	6	corti	corti	PROPN
admet-916	205	7	,	,	PUNCT
admet-916	205	8	f.	f.	PROPN
admet-916	205	9	maestrelli	maestrelli	PROPN
admet-916	205	10	,	,	PUNCT
admet-916	205	11	m.	m.	NOUN
admet-916	205	12	cirri	cirri	PROPN
admet-916	205	13	,	,	PUNCT
admet-916	205	14	s.	s.	PROPN
admet-916	205	15	furlanetto	furlanetto	PROPN
admet-916	205	16	,	,	PUNCT
admet-916	205	17	p.	p.	PROPN
admet-916	205	18	mura	mura	PROPN
admet-916	205	19	.	.	PUNCT
admet-916	206	1	development	development	NOUN
admet-916	206	2	and	and	CCONJ
admet-916	206	3	evaluation	evaluation	NOUN
admet-916	206	4	of	of	ADP
admet-916	206	5	an	an	DET
admet-916	206	6	in	in	ADP
admet-916	206	7	vitro	vitro	X
admet-916	206	8	method	method	NOUN
admet-916	206	9	for	for	ADP
admet-916	206	10	prediction	prediction	NOUN
admet-916	206	11	of	of	ADP
admet-916	206	12	human	human	ADJ
admet-916	206	13	drug	drug	NOUN
admet-916	206	14	absorption	absorption	NOUN
admet-916	206	15	assessment	assessment	NOUN
admet-916	206	16	of	of	ADP
admet-916	206	17	artificial	artificial	ADJ
admet-916	206	18	membrane	membrane	NOUN
admet-916	206	19	composition	composition	NOUN
admet-916	206	20	,	,	PUNCT
admet-916	206	21	european	european	PROPN
admet-916	206	22	journal	journal	PROPN
admet-916	206	23	of	of	ADP
admet-916	206	24	pharmaceutical	pharmaceutical	PROPN
admet-916	206	25	sciences	science	NOUN
admet-916	206	26	27	27	NUM
admet-916	206	27	(	(	PUNCT
admet-916	206	28	2006	2006	NUM
admet-916	206	29	)	)	PUNCT
admet-916	206	30	346	346	NUM
admet-916	206	31	-	-	SYM
admet-916	206	32	353	353	NUM
admet-916	206	33	.	.	PUNCT
admet-916	207	1	https://doi.org/10.1016/	https://doi.org/10.1016/	PROPN
admet-916	207	2	j.ejps.2005.11.004	j.ejps.2005.11.004	PROPN
admet-916	207	3	.	.	PUNCT
admet-916	208	1	[	[	X
admet-916	208	2	2	2	NUM
admet-916	208	3	]	]	X
admet-916	208	4	g.l	g.l	PROPN
admet-916	208	5	.	.	PROPN
admet-916	208	6	amidon	amidon	PROPN
admet-916	208	7	,	,	PUNCT
admet-916	208	8	h.	h.	PROPN
admet-916	208	9	lennernas	lennernas	PROPN
admet-916	208	10	,	,	PUNCT
admet-916	208	11	v.p	v.p	PROPN
admet-916	208	12	.	.	PROPN
admet-916	208	13	shah	shah	PROPN
admet-916	208	14	,	,	PUNCT
admet-916	208	15	j.r	j.r	PROPN
admet-916	208	16	.	.	PROPN
admet-916	208	17	crison	crison	PROPN
admet-916	208	18	.	.	PUNCT
admet-916	209	1	a	a	DET
admet-916	209	2	theoretical	theoretical	ADJ
admet-916	209	3	basis	basis	NOUN
admet-916	209	4	for	for	ADP
admet-916	209	5	a	a	DET
admet-916	209	6	biopharmaceutic	biopharmaceutic	ADJ
admet-916	209	7	drug	drug	NOUN
admet-916	209	8	classification	classification	NOUN
admet-916	209	9	:	:	PUNCT
admet-916	209	10	the	the	DET
admet-916	209	11	correlation	correlation	NOUN
admet-916	209	12	of	of	ADP
admet-916	209	13	in	in	ADP
admet-916	209	14	vitro	vitro	X
admet-916	209	15	drug	drug	NOUN
admet-916	209	16	product	product	NOUN
admet-916	209	17	dissolution	dissolution	NOUN
admet-916	209	18	and	and	CCONJ
admet-916	209	19	in	in	ADP
admet-916	209	20	vivo	vivo	ADJ
admet-916	209	21	bioavailability	bioavailability	NOUN
admet-916	209	22	,	,	PUNCT
admet-916	209	23	pharmaceutical	pharmaceutical	ADJ
admet-916	209	24	research	research	NOUN
admet-916	209	25	12	12	NUM
admet-916	209	26	(	(	PUNCT
admet-916	209	27	1995	1995	NUM
admet-916	209	28	)	)	PUNCT
admet-916	209	29	413	413	NUM
admet-916	209	30	-	-	SYM
admet-916	209	31	420	420	NUM
admet-916	209	32	.	.	PUNCT
admet-916	210	1	https://doi.org/10.1023/a:1016212804288	https://doi.org/10.1023/a:1016212804288	NOUN
admet-916	210	2	.	.	PUNCT
admet-916	211	1	[	[	X
admet-916	211	2	3	3	NUM
admet-916	211	3	]	]	PUNCT
admet-916	211	4	a.	a.	NOUN
admet-916	211	5	avdeef	avdeef	PROPN
admet-916	211	6	.	.	PUNCT
admet-916	212	1	physicochemical	physicochemical	ADJ
admet-916	212	2	profiling	profiling	NOUN
admet-916	212	3	(	(	PUNCT
admet-916	212	4	solubility	solubility	NOUN
admet-916	212	5	,	,	PUNCT
admet-916	212	6	permeability	permeability	NOUN
admet-916	212	7	and	and	CCONJ
admet-916	212	8	charge	charge	NOUN
admet-916	212	9	state	state	NOUN
admet-916	212	10	)	)	PUNCT
admet-916	212	11	,	,	PUNCT
admet-916	212	12	current	current	ADJ
admet-916	212	13	topics	topic	NOUN
admet-916	212	14	in	in	ADP
admet-916	212	15	medicinal	medicinal	ADJ
admet-916	212	16	chemistry	chemistry	NOUN
admet-916	212	17	1	1	NUM
admet-916	212	18	(	(	PUNCT
admet-916	212	19	2001	2001	NUM
admet-916	212	20	)	)	PUNCT
admet-916	212	21	277	277	NUM
admet-916	212	22	-	-	SYM
admet-916	212	23	351	351	NUM
admet-916	212	24	.	.	PUNCT
admet-916	213	1	https://doi.org/10.2174/1568026013395100	https://doi.org/10.2174/1568026013395100	PROPN
admet-916	213	2	.	.	PUNCT
admet-916	214	1	[	[	X
admet-916	214	2	4	4	X
admet-916	214	3	]	]	X
admet-916	214	4	h.	h.	PROPN
admet-916	214	5	lennernas	lennernas	PROPN
admet-916	214	6	.	.	PUNCT
admet-916	215	1	intestinal	intestinal	ADJ
admet-916	215	2	permeability	permeability	NOUN
admet-916	215	3	and	and	CCONJ
admet-916	215	4	its	its	PRON
admet-916	215	5	relevance	relevance	NOUN
admet-916	215	6	for	for	ADP
admet-916	215	7	absorption	absorption	NOUN
admet-916	215	8	and	and	CCONJ
admet-916	215	9	elimination	elimination	NOUN
admet-916	215	10	,	,	PUNCT
admet-916	215	11	xenobiotica	xenobiotica	PROPN
admet-916	215	12	37	37	NUM
admet-916	215	13	(	(	PUNCT
admet-916	215	14	2007	2007	NUM
admet-916	215	15	)	)	PUNCT
admet-916	215	16	1015–1051	1015–1051	NUM
admet-916	215	17	.	.	PUNCT
admet-916	215	18	https://doi.org/10.1080/00498250701704819	https://doi.org/10.1080/00498250701704819	NOUN
admet-916	215	19	.	.	PUNCT
admet-916	216	1	[	[	X
admet-916	216	2	5	5	NUM
admet-916	216	3	]	]	PUNCT
admet-916	216	4	i.	i.	NOUN
admet-916	216	5	shohin	shohin	PROPN
admet-916	216	6	,	,	PUNCT
admet-916	216	7	j.	j.	PROPN
admet-916	216	8	kulinich	kulinich	PROPN
admet-916	216	9	,	,	PUNCT
admet-916	216	10	g.	g.	PROPN
admet-916	216	11	ramenskaya	ramenskaya	PROPN
admet-916	216	12	,	,	PUNCT
admet-916	216	13	b.	b.	PROPN
admet-916	216	14	abrahamsson	abrahamsson	PROPN
admet-916	216	15	,	,	PUNCT
admet-916	216	16	s.	s.	PROPN
admet-916	216	17	kopp	kopp	PROPN
admet-916	216	18	,	,	PUNCT
admet-916	216	19	p.	p.	PROPN
admet-916	216	20	langguth	langguth	PROPN
admet-916	216	21	,	,	PUNCT
admet-916	216	22	j.	j.	PROPN
admet-916	216	23	polli	polli	PROPN
admet-916	216	24	,	,	PUNCT
admet-916	216	25	v.	v.	ADP
admet-916	216	26	shah	shah	PROPN
admet-916	216	27	,	,	PUNCT
admet-916	216	28	d.	d.	PROPN
admet-916	216	29	groot	groot	PROPN
admet-916	216	30	,	,	PUNCT
admet-916	216	31	d.	d.	PROPN
admet-916	216	32	barends	barends	PROPN
admet-916	216	33	,	,	PUNCT
admet-916	216	34	j.	j.	PROPN
admet-916	216	35	dressman	dressman	PROPN
admet-916	216	36	.	.	PUNCT
admet-916	217	1	biowaiver	biowaiver	PROPN
admet-916	217	2	monographs	monograph	NOUN
admet-916	217	3	for	for	ADP
admet-916	217	4	immediate	immediate	ADJ
admet-916	217	5	-	-	PUNCT
admet-916	217	6	release	release	NOUN
admet-916	217	7	solid	solid	ADJ
admet-916	217	8	oral	oral	ADJ
admet-916	217	9	dosage	dosage	NOUN
admet-916	217	10	forms	form	NOUN
admet-916	217	11	:	:	PUNCT
admet-916	217	12	ketoprofen	ketoprofen	VERB
admet-916	217	13	,	,	PUNCT
admet-916	217	14	journal	journal	NOUN
admet-916	217	15	of	of	ADP
admet-916	217	16	pharmaceutical	pharmaceutical	ADJ
admet-916	217	17	sciences	science	NOUN
admet-916	217	18	101	101	NUM
admet-916	217	19	(	(	PUNCT
admet-916	217	20	2012	2012	NUM
admet-916	217	21	)	)	PUNCT
admet-916	217	22	3593	3593	NUM
admet-916	217	23	-	-	SYM
admet-916	217	24	3603	3603	NUM
admet-916	217	25	.	.	PUNCT
admet-916	218	1	https://doi.org/10.1002/jps.23233	https://doi.org/10.1002/jps.23233	NOUN
admet-916	218	2	.	.	PUNCT
admet-916	219	1	[	[	X
admet-916	219	2	6	6	NUM
admet-916	219	3	]	]	PUNCT
admet-916	219	4	c.-l	c.-l	NOUN
admet-916	219	5	.	.	PUNCT
admet-916	220	1	cheng	cheng	PROPN
admet-916	220	2	,	,	PUNCT
admet-916	220	3	l.	l.	PROPN
admet-916	220	4	x.	x.	PROPN
admet-916	220	5	yu	yu	PROPN
admet-916	220	6	,	,	PUNCT
admet-916	220	7	h.-l	h.-l	PROPN
admet-916	220	8	.	.	PUNCT
admet-916	221	1	lee	lee	PROPN
admet-916	221	2	,	,	PUNCT
admet-916	221	3	c.-y	c.-y	NOUN
admet-916	221	4	.	.	PUNCT
admet-916	222	1	yang	yang	PROPN
admet-916	222	2	,	,	PUNCT
admet-916	222	3	c.-s	c.-	NOUN
admet-916	222	4	.	.	PUNCT
admet-916	223	1	lue	lue	PROPN
admet-916	223	2	,	,	PUNCT
admet-916	223	3	c.-h	c.-h	PROPN
admet-916	223	4	.	.	PUNCT
admet-916	224	1	chou	chou	PROPN
admet-916	224	2	.	.	PUNCT
admet-916	225	1	biowaiver	biowaiver	PROPN
admet-916	225	2	extension	extension	NOUN
admet-916	225	3	potential	potential	NOUN
admet-916	225	4	to	to	ADP
admet-916	225	5	bcs	bcs	NOUN
admet-916	225	6	class	class	NOUN
admet-916	225	7	iii	iii	NUM
admet-916	225	8	high	high	ADJ
admet-916	225	9	solubility	solubility	NOUN
admet-916	225	10	-	-	PUNCT
admet-916	225	11	low	low	ADJ
admet-916	225	12	permeability	permeability	NOUN
admet-916	225	13	drugs	drug	NOUN
admet-916	225	14	:	:	PUNCT
admet-916	225	15	bridging	bridge	VERB
admet-916	225	16	evidence	evidence	NOUN
admet-916	225	17	for	for	ADP
admet-916	225	18	metformin	metformin	NOUN
admet-916	225	19	immediate	immediate	ADJ
admet-916	225	20	-	-	PUNCT
admet-916	225	21	release	release	NOUN
admet-916	225	22	tablet	tablet	NOUN
admet-916	225	23	,	,	PUNCT
admet-916	225	24	european	european	ADJ
admet-916	225	25	journal	journal	PROPN
admet-916	225	26	of	of	ADP
admet-916	225	27	pharmaceutical	pharmaceutical	PROPN
admet-916	225	28	sciences	science	NOUN
admet-916	225	29	22	22	NUM
admet-916	225	30	(	(	PUNCT
admet-916	225	31	2004	2004	NUM
admet-916	225	32	)	)	PUNCT
admet-916	225	33	297	297	NUM
admet-916	225	34	-	-	SYM
admet-916	225	35	304	304	NUM
admet-916	225	36	.	.	PUNCT
admet-916	226	1	https://doi.org/10.1016/j.ejps.2004.03.016	https://doi.org/10.1016/j.ejps.2004.03.016	PROPN
admet-916	226	2	.	.	PUNCT
admet-916	227	1	[	[	X
admet-916	227	2	7	7	X
admet-916	227	3	]	]	X
admet-916	227	4	j.	j.	PROPN
admet-916	227	5	sheng	sheng	PROPN
admet-916	227	6	,	,	PUNCT
admet-916	227	7	n.	n.	PROPN
admet-916	227	8	a.	a.	PROPN
admet-916	227	9	kasim	kasim	PROPN
admet-916	227	10	,	,	PUNCT
admet-916	227	11	r.	r.	PROPN
admet-916	227	12	chandrasekharan	chandrasekharan	PROPN
admet-916	227	13	,	,	PUNCT
admet-916	227	14	g.	g.	PROPN
admet-916	227	15	l.	l.	PROPN
admet-916	227	16	amidon	amidon	PROPN
admet-916	227	17	.	.	PUNCT
admet-916	228	1	solubilization	solubilization	NOUN
admet-916	228	2	and	and	CCONJ
admet-916	228	3	dissolution	dissolution	NOUN
admet-916	228	4	of	of	ADP
admet-916	228	5	insoluble	insoluble	ADJ
admet-916	228	6	weak	weak	ADJ
admet-916	228	7	acid	acid	NOUN
admet-916	228	8	,	,	PUNCT
admet-916	228	9	ketoprofen	ketoprofen	VERB
admet-916	228	10	:	:	PUNCT
admet-916	228	11	effects	effect	NOUN
admet-916	228	12	of	of	ADP
admet-916	228	13	ph	ph	NOUN
admet-916	228	14	combined	combine	VERB
admet-916	228	15	with	with	ADP
admet-916	228	16	surfactant	surfactant	ADJ
admet-916	228	17	,	,	PUNCT
admet-916	228	18	european	european	ADJ
admet-916	228	19	journal	journal	PROPN
admet-916	228	20	of	of	ADP
admet-916	228	21	pharmaceutical	pharmaceutical	NOUN
admet-916	228	22	sciiences	sciience	NOUN
admet-916	228	23	29	29	NUM
admet-916	228	24	(	(	PUNCT
admet-916	228	25	2006	2006	NUM
admet-916	228	26	)	)	PUNCT
admet-916	228	27	306–314	306–314	NUM
admet-916	228	28	.	.	PUNCT
admet-916	229	1	https://doi.org/10.1016/j.ejps.2006.06.006	https://doi.org/10.1016/j.ejps.2006.06.006	NUM
admet-916	229	2	.	.	PUNCT
admet-916	230	1	[	[	X
admet-916	230	2	8	8	NUM
admet-916	230	3	]	]	X
admet-916	230	4	j.e	j.e	PROPN
admet-916	230	5	.	.	PROPN
admet-916	230	6	gunton	gunton	PROPN
admet-916	230	7	,	,	PUNCT
admet-916	230	8	p.j	p.j	PROPN
admet-916	230	9	.	.	PROPN
admet-916	230	10	delhanty	delhanty	PROPN
admet-916	230	11	,	,	PUNCT
admet-916	230	12	s.	s.	PROPN
admet-916	230	13	takahashi	takahashi	PROPN
admet-916	230	14	,	,	PUNCT
admet-916	230	15	r.c	r.c	PROPN
admet-916	230	16	.	.	PROPN
admet-916	230	17	baxter	baxter	PROPN
admet-916	230	18	.	.	PUNCT
admet-916	231	1	metformin	metformin	PROPN
admet-916	231	2	rapidly	rapidly	ADV
admet-916	231	3	increases	increase	VERB
admet-916	231	4	insulin	insulin	NOUN
admet-916	231	5	acceptor	acceptor	NOUN
admet-916	231	6	activation	activation	NOUN
admet-916	231	7	in	in	ADP
admet-916	231	8	human	human	ADJ
admet-916	231	9	liver	liver	NOUN
admet-916	231	10	and	and	CCONJ
admet-916	231	11	signals	signal	NOUN
admet-916	231	12	preferentially	preferentially	ADV
admet-916	231	13	through	through	ADP
admet-916	231	14	insulin	insulin	NOUN
admet-916	231	15	-	-	PUNCT
admet-916	231	16	acceptor	acceptor	NOUN
admet-916	231	17	substrate-2	substrate-2	PROPN
admet-916	231	18	,	,	PUNCT
admet-916	231	19	journal	journal	NOUN
admet-916	231	20	of	of	ADP
admet-916	231	21	clinical	clinical	ADJ
admet-916	231	22	endocrinology	endocrinology	NOUN
admet-916	231	23	and	and	CCONJ
admet-916	231	24	metabolism	metabolism	NOUN
admet-916	231	25	88	88	NUM
admet-916	231	26	(	(	PUNCT
admet-916	231	27	2003	2003	NUM
admet-916	231	28	)	)	PUNCT
admet-916	231	29	1323–1332	1323–1332	NUM
admet-916	231	30	.	.	PUNCT
admet-916	232	1	https://doi.org/10.1210/jc.2002021394	https://doi.org/10.1210/jc.2002021394	PUNCT
admet-916	233	1	[	[	X
admet-916	233	2	9	9	NUM
admet-916	233	3	]	]	X
admet-916	233	4	g.s	g.s	PROPN
admet-916	233	5	.	.	PROPN
admet-916	233	6	clarke	clarke	PROPN
admet-916	233	7	,	,	PUNCT
admet-916	233	8	a.e	a.e	PROPN
admet-916	233	9	.	.	PROPN
admet-916	233	10	bretnall	bretnall	PROPN
admet-916	233	11	,	,	PUNCT
admet-916	233	12	metformin	metformin	NOUN
admet-916	233	13	hydrochloride	hydrochloride	NOUN
admet-916	233	14	,	,	PUNCT
admet-916	233	15	in	in	ADP
admet-916	233	16	analytical	analytical	ADJ
admet-916	233	17	profiles	profile	NOUN
admet-916	233	18	of	of	ADP
admet-916	233	19	drug	drug	NOUN
admet-916	233	20	substances	substance	NOUN
admet-916	233	21	and	and	CCONJ
admet-916	233	22	excipients	excipient	NOUN
admet-916	233	23	,	,	PUNCT
admet-916	233	24	h.g	h.g	PROPN
admet-916	233	25	.	.	PUNCT
admet-916	233	26	brittain	brittain	PROPN
admet-916	233	27	,	,	PUNCT
admet-916	233	28	ed	ed	PROPN
admet-916	233	29	.	.	PROPN
admet-916	233	30	,	,	PUNCT
admet-916	233	31	academic	academic	ADJ
admet-916	233	32	press	press	NOUN
admet-916	233	33	,	,	PUNCT
admet-916	233	34	san	san	PROPN
admet-916	233	35	diego	diego	PROPN
admet-916	233	36	,	,	PUNCT
admet-916	233	37	ca	ca	PROPN
admet-916	233	38	,	,	PUNCT
admet-916	233	39	usa	usa	PROPN
admet-916	233	40	,	,	PUNCT
admet-916	233	41	1998	1998	NUM
admet-916	233	42	,	,	PUNCT
admet-916	233	43	243	243	NUM
admet-916	233	44	-	-	SYM
admet-916	233	45	284	284	NUM
admet-916	233	46	isbn	isbn	NOUN
admet-916	233	47	:	:	PUNCT
admet-916	233	48	9780122608254	9780122608254	NUM
admet-916	233	49	.	.	PUNCT
admet-916	234	1	[	[	X
admet-916	234	2	10	10	NUM
admet-916	234	3	]	]	X
admet-916	234	4	p.	p.	PROPN
admet-916	234	5	berben	berben	PROPN
admet-916	234	6	,	,	PUNCT
admet-916	234	7	a.	a.	PROPN
admet-916	234	8	bauer	bauer	PROPN
admet-916	234	9	-	-	PUNCT
admet-916	234	10	brandl	brandl	PROPN
admet-916	234	11	,	,	PUNCT
admet-916	234	12	m.	m.	NOUN
admet-916	234	13	brandl	brandl	PROPN
admet-916	234	14	,	,	PUNCT
admet-916	234	15	b.	b.	PROPN
admet-916	234	16	faller	faller	PROPN
admet-916	234	17	,	,	PUNCT
admet-916	234	18	g.e	g.e	PROPN
admet-916	234	19	.	.	PROPN
admet-916	234	20	flaten	flaten	PROPN
admet-916	234	21	,	,	PUNCT
admet-916	234	22	a.c	a.c	PROPN
admet-916	234	23	.	.	PROPN
admet-916	234	24	jacobsen	jacobsen	PROPN
admet-916	234	25	,	,	PUNCT
admet-916	234	26	j.	j.	PROPN
admet-916	234	27	brouwersa	brouwersa	PROPN
admet-916	234	28	,	,	PUNCT
admet-916	234	29	p.	p.	NOUN
admet-916	234	30	augustijns	augustijns	NOUN
admet-916	234	31	.	.	PUNCT
admet-916	235	1	drug	drug	NOUN
admet-916	235	2	permeability	permeability	NOUN
admet-916	235	3	profiling	profiling	NOUN
admet-916	235	4	using	use	VERB
admet-916	235	5	cell	cell	NOUN
admet-916	235	6	-	-	PUNCT
admet-916	235	7	free	free	ADJ
admet-916	235	8	permeation	permeation	NOUN
admet-916	235	9	tools	tool	NOUN
admet-916	235	10	:	:	PUNCT
admet-916	235	11	overview	overview	NOUN
admet-916	235	12	and	and	CCONJ
admet-916	235	13	applications	application	NOUN
admet-916	235	14	,	,	PUNCT
admet-916	235	15	european	european	PROPN
admet-916	235	16	journal	journal	PROPN
admet-916	235	17	of	of	ADP
admet-916	235	18	pharmaceutical	pharmaceutical	PROPN
admet-916	235	19	sciences	science	NOUN
admet-916	235	20	119	119	NUM
admet-916	235	21	(	(	PUNCT
admet-916	235	22	2018	2018	NUM
admet-916	235	23	)	)	PUNCT
admet-916	236	1	219–233	219–233	NUM
admet-916	236	2	.	.	PUNCT
admet-916	237	1	https://doi.org/	https://doi.org/	VERB
admet-916	237	2	10.1016	10.1016	NUM
admet-916	237	3	/	/	SYM
admet-916	237	4	j.ejps.2018.04.016	j.ejps.2018.04.016	PROPN
admet-916	237	5	.	.	PUNCT
admet-916	238	1	[	[	X
admet-916	238	2	11	11	NUM
admet-916	238	3	]	]	X
admet-916	238	4	d.a	d.a	PROPN
admet-916	238	5	.	.	PROPN
admet-916	238	6	volpe	volpe	PROPN
admet-916	238	7	,	,	PUNCT
admet-916	238	8	drug	drug	NOUN
admet-916	238	9	permeability	permeability	NOUN
admet-916	238	10	studies	study	NOUN
admet-916	238	11	in	in	ADP
admet-916	238	12	regulatory	regulatory	ADJ
admet-916	238	13	biowaiver	biowaiver	NOUN
admet-916	238	14	applications	application	NOUN
admet-916	238	15	,	,	PUNCT
admet-916	238	16	in	in	ADP
admet-916	238	17	drug	drug	NOUN
admet-916	238	18	absorption	absorption	NOUN
admet-916	238	19	studies	study	NOUN
admet-916	238	20	,	,	PUNCT
admet-916	238	21	biotechnology	biotechnology	NOUN
admet-916	238	22	:	:	PUNCT
admet-916	238	23	pharmaceutical	pharmaceutical	NOUN
admet-916	238	24	aspects	aspect	NOUN
admet-916	238	25	,	,	PUNCT
admet-916	238	26	c.	c.	PROPN
admet-916	238	27	ehrhardt	ehrhardt	PROPN
admet-916	238	28	,	,	PUNCT
admet-916	238	29	k.j	k.j	PROPN
admet-916	238	30	.	.	PUNCT
admet-916	238	31	kim	kim	PROPN
admet-916	238	32	,	,	PUNCT
admet-916	238	33	eds	eds	PROPN
admet-916	238	34	.	.	PROPN
admet-916	238	35	,	,	PUNCT
admet-916	238	36	springer	springer	NOUN
admet-916	238	37	,	,	PUNCT
admet-916	238	38	boston	boston	PROPN
admet-916	238	39	,	,	PUNCT
admet-916	238	40	ma	ma	PROPN
admet-916	238	41	,	,	PUNCT
admet-916	238	42	usa	usa	PROPN
admet-916	238	43	,	,	PUNCT
admet-916	238	44	2008	2008	NUM
admet-916	238	45	,	,	PUNCT
admet-916	238	46	665–680	665–680	NUM
admet-916	238	47	.	.	PUNCT
admet-916	239	1	https://doi.org/10.1007/978-0-387-74901-3_28	https://doi.org/10.1007/978-0-387-74901-3_28	PROPN
admet-916	239	2	.	.	PUNCT
admet-916	240	1	[	[	X
admet-916	240	2	12	12	NUM
admet-916	240	3	]	]	PUNCT
admet-916	240	4	a.	a.	NOUN
admet-916	240	5	avdeef	avdeef	PROPN
admet-916	240	6	,	,	PUNCT
admet-916	240	7	solubility	solubility	NOUN
admet-916	240	8	,	,	PUNCT
admet-916	240	9	permeability	permeability	NOUN
admet-916	240	10	,	,	PUNCT
admet-916	240	11	and	and	CCONJ
admet-916	240	12	charge	charge	NOUN
admet-916	240	13	state	state	NOUN
admet-916	240	14	,	,	PUNCT
admet-916	240	15	in	in	ADP
admet-916	240	16	absorption	absorption	NOUN
admet-916	240	17	and	and	CCONJ
admet-916	240	18	drug	drug	NOUN
admet-916	240	19	development	development	NOUN
admet-916	240	20	,	,	PUNCT
admet-916	240	21	2nd	2nd	ADJ
admet-916	240	22	ed	ed	NOUN
admet-916	240	23	.	.	PROPN
admet-916	240	24	,	,	PUNCT
admet-916	240	25	a.	a.	PROPN
admet-916	240	26	avdeef	avdeef	PROPN
admet-916	240	27	,	,	PUNCT
admet-916	240	28	ed	ed	NOUN
admet-916	240	29	.	.	PROPN
admet-916	240	30	,	,	PUNCT
admet-916	240	31	john	john	PROPN
admet-916	240	32	wiley	wiley	PROPN
admet-916	240	33	&	&	CCONJ
admet-916	240	34	sons	sons	PROPN
admet-916	240	35	,	,	PUNCT
admet-916	240	36	inc	inc	PROPN
admet-916	240	37	.	.	PROPN
admet-916	240	38	,	,	PUNCT
admet-916	240	39	new	new	PROPN
admet-916	240	40	jersey	jersey	PROPN
admet-916	240	41	,	,	PUNCT
admet-916	240	42	usa	usa	PROPN
admet-916	240	43	,	,	PUNCT
admet-916	240	44	2012	2012	NUM
admet-916	240	45	,	,	PUNCT
admet-916	240	46	116	116	NUM
admet-916	240	47	-	-	SYM
admet-916	240	48	246	246	NUM
admet-916	240	49	.	.	PUNCT
admet-916	241	1	https://doi	https://doi	PROPN
admet-916	241	2	.	.	PUNCT
admet-916	241	3	.org/10.1002/9781118286067	.org/10.1002/9781118286067	PUNCT
admet-916	241	4	.	.	PUNCT
admet-916	242	1	[	[	X
admet-916	242	2	13	13	NUM
admet-916	242	3	]	]	PUNCT
admet-916	242	4	r.	r.	PROPN
admet-916	242	5	joubert	joubert	PROPN
admet-916	242	6	,	,	PUNCT
admet-916	242	7	j.d	j.d	PROPN
admet-916	242	8	.	.	PROPN
admet-916	242	9	steyn	steyn	PROPN
admet-916	242	10	,	,	PUNCT
admet-916	242	11	h.j	h.j	PROPN
admet-916	242	12	.	.	PROPN
admet-916	242	13	heystek	heystek	PROPN
admet-916	242	14	,	,	PUNCT
admet-916	242	15	j.h	j.h	PROPN
admet-916	242	16	.	.	PROPN
admet-916	242	17	steenekamp	steenekamp	PROPN
admet-916	242	18	,	,	PUNCT
admet-916	242	19	j.l	j.l	PROPN
admet-916	242	20	.	.	PROPN
admet-916	242	21	du	du	PROPN
admet-916	242	22	preez	preez	PROPN
admet-916	242	23	,	,	PUNCT
admet-916	242	24	j.h	j.h	PROPN
admet-916	242	25	.	.	PROPN
admet-916	242	26	hamman	hamman	PROPN
admet-916	242	27	.	.	PUNCT
admet-916	243	1	in	in	ADP
admet-916	243	2	vitro	vitro	X
admet-916	243	3	oral	oral	ADJ
admet-916	243	4	drug	drug	NOUN
admet-916	243	5	permeation	permeation	NOUN
admet-916	243	6	models	model	NOUN
admet-916	243	7	:	:	PUNCT
admet-916	243	8	the	the	DET
admet-916	243	9	importance	importance	NOUN
admet-916	243	10	of	of	ADP
admet-916	243	11	taking	take	VERB
admet-916	243	12	physiological	physiological	ADJ
admet-916	243	13	and	and	CCONJ
admet-916	243	14	physico	physico	NOUN
admet-916	243	15	-	-	PUNCT
admet-916	243	16	chemical	chemical	NOUN
admet-916	243	17	factors	factor	NOUN
admet-916	243	18	into	into	ADP
admet-916	243	19	consideration	consideration	NOUN
admet-916	243	20	,	,	PUNCT
admet-916	243	21	expert	expert	ADJ
admet-916	243	22	opinion	opinion	NOUN
admet-916	243	23	on	on	ADP
admet-916	243	24	drug	drug	NOUN
admet-916	243	25	delivery	delivery	NOUN
admet-916	243	26	14	14	NUM
admet-916	243	27	(	(	PUNCT
admet-916	243	28	2016	2016	NUM
admet-916	243	29	)	)	PUNCT
admet-916	244	1	179–187	179–187	NUM
admet-916	244	2	https://doi.org/	https://doi.org/	NOUN
admet-916	244	3	10.1080/17425247.2016.1211639	10.1080/17425247.2016.1211639	NUM
admet-916	244	4	.	.	PUNCT
admet-916	245	1	[	[	X
admet-916	245	2	14	14	NUM
admet-916	245	3	]	]	X
admet-916	245	4	d.	d.	PROPN
admet-916	245	5	manallack	manallack	PROPN
admet-916	245	6	,	,	PUNCT
admet-916	245	7	r.	r.	PROPN
admet-916	245	8	prankerd	prankerd	PROPN
admet-916	245	9	,	,	PUNCT
admet-916	245	10	g.	g.	PROPN
admet-916	245	11	nassta	nassta	PROPN
admet-916	245	12	,	,	PUNCT
admet-916	245	13	o.	o.	NOUN
admet-916	245	14	ursu	ursu	NOUN
admet-916	245	15	,	,	PUNCT
admet-916	245	16	t.	t.	PROPN
admet-916	245	17	oprea	oprea	PROPN
admet-916	245	18	,	,	PUNCT
admet-916	245	19	d.	d.	PROPN
admet-916	245	20	chalmers	chalmers	PROPN
admet-916	245	21	.	.	PUNCT
admet-916	246	1	a	a	DET
admet-916	246	2	chemogenomic	chemogenomic	ADJ
admet-916	246	3	analysis	analysis	NOUN
admet-916	246	4	of	of	ADP
admet-916	246	5	ionization	ionization	NOUN
admet-916	246	6	constants	constant	NOUN
admet-916	246	7	-	-	PUNCT
admet-916	246	8	implications	implication	NOUN
admet-916	246	9	for	for	ADP
admet-916	246	10	drug	drug	NOUN
admet-916	246	11	discovery	discovery	NOUN
admet-916	246	12	,	,	PUNCT
admet-916	246	13	chemmedchem	chemmedchem	PROPN
admet-916	246	14	8	8	NUM
admet-916	246	15	(	(	PUNCT
admet-916	246	16	2013	2013	NUM
admet-916	246	17	)	)	PUNCT
admet-916	246	18	242	242	NUM
admet-916	246	19	-	-	SYM
admet-916	246	20	255	255	NUM
admet-916	246	21	.	.	PUNCT
admet-916	247	1	https://doi.org/10.1002/cmdc.201200507	https://doi.org/10.1002/cmdc.201200507	PROPN
admet-916	247	2	.	.	PROPN
admet-916	248	1	http://dx.doi.org/10.5599/admet.916	http://dx.doi.org/10.5599/admet.916	PROPN
admet-916	248	2	https://doi.org/10.1016/j.ejps.2005.11.004	https://doi.org/10.1016/j.ejps.2005.11.004	PROPN
admet-916	248	3	https://doi.org/10.1016/j.ejps.2005.11.004	https://doi.org/10.1016/j.ejps.2005.11.004	VERB
admet-916	248	4	https://doi.org/10.1023/a:1016212804288	https://doi.org/10.1023/a:1016212804288	NOUN
admet-916	248	5	https://doi.org/10.2174/1568026013395100	https://doi.org/10.2174/1568026013395100	PROPN
admet-916	248	6	https://doi.org/10.1080/00498250701704819	https://doi.org/10.1080/00498250701704819	NOUN
admet-916	248	7	https://doi.org/10.1002/jps.23233	https://doi.org/10.1002/jps.23233	VERB
admet-916	248	8	https://doi.org/10.1016/j.ejps.2004.03.016	https://doi.org/10.1016/j.ejps.2004.03.016	PROPN
admet-916	248	9	https://doi.org/10.1016/j.ejps.2006.06.006	https://doi.org/10.1016/j.ejps.2006.06.006	NUM
admet-916	248	10	https://doi.org/10.1210/jc.2002-021394	https://doi.org/10.1210/jc.2002-021394	NOUN
admet-916	248	11	https://doi.org/10.1210/jc.2002-021394	https://doi.org/10.1210/jc.2002-021394	NOUN
admet-916	248	12	https://doi.org/10.1016/j.ejps.2018.04.016	https://doi.org/10.1016/j.ejps.2018.04.016	PROPN
admet-916	248	13	https://doi.org/10.1016/j.ejps.2018.04.016	https://doi.org/10.1016/j.ejps.2018.04.016	PROPN
admet-916	249	1	https://doi.org/10.1007/978-0-387-74901-3_28	https://doi.org/10.1007/978-0-387-74901-3_28	PROPN
admet-916	249	2	https://doi.org/10.1080/17425247.2016.1211639	https://doi.org/10.1080/17425247.2016.1211639	PROPN
admet-916	249	3	https://dx.doi.org/10.1002%2fcmdc.201200507	https://dx.doi.org/10.1002%2fcmdc.201200507	PROPN
admet-916	249	4	alisa	alisa	PROPN
admet-916	249	5	elezović	elezović	PROPN
admet-916	249	6	et	et	PROPN
admet-916	249	7	al	al	PROPN
admet-916	249	8	.	.	PROPN
admet-916	249	9	admet	admet	PROPN
admet-916	249	10	&	&	CCONJ
admet-916	249	11	dmpk	dmpk	PROPN
admet-916	249	12	9(1	9(1	NUM
admet-916	249	13	)	)	PUNCT
admet-916	249	14	(	(	PUNCT
admet-916	249	15	2021	2021	NUM
admet-916	249	16	)	)	PUNCT
admet-916	249	17	57	57	NUM
admet-916	249	18	-	-	SYM
admet-916	249	19	68	68	NUM
admet-916	249	20	68	68	NUM
admet-916	249	21	[	[	X
admet-916	249	22	15	15	NUM
admet-916	249	23	]	]	X
admet-916	249	24	g.	g.	PROPN
admet-916	249	25	corti	corti	PROPN
admet-916	249	26	,	,	PUNCT
admet-916	249	27	f.	f.	PROPN
admet-916	249	28	maestrelli	maestrelli	PROPN
admet-916	249	29	,	,	PUNCT
admet-916	249	30	m.	m.	NOUN
admet-916	249	31	cirri	cirri	PROPN
admet-916	249	32	,	,	PUNCT
admet-916	249	33	n.	n.	PROPN
admet-916	249	34	zerrouk	zerrouk	PROPN
admet-916	249	35	,	,	PUNCT
admet-916	249	36	p.	p.	PROPN
admet-916	249	37	mura	mura	PROPN
admet-916	249	38	.	.	PUNCT
admet-916	250	1	development	development	NOUN
admet-916	250	2	and	and	CCONJ
admet-916	250	3	evaluation	evaluation	NOUN
admet-916	250	4	of	of	ADP
admet-916	250	5	an	an	DET
admet-916	250	6	in	in	ADP
admet-916	250	7	vitro	vitro	X
admet-916	250	8	method	method	NOUN
admet-916	250	9	for	for	ADP
admet-916	250	10	prediction	prediction	NOUN
admet-916	250	11	of	of	ADP
admet-916	250	12	human	human	ADJ
admet-916	250	13	drug	drug	PROPN
admet-916	250	14	absorption	absorption	NOUN
admet-916	250	15	ii	ii	NOUN
admet-916	250	16	demonstration	demonstration	NOUN
admet-916	250	17	of	of	ADP
admet-916	250	18	the	the	DET
admet-916	250	19	method	method	NOUN
admet-916	250	20	suitability	suitability	NOUN
admet-916	250	21	,	,	PUNCT
admet-916	250	22	european	european	PROPN
admet-916	250	23	journal	journal	PROPN
admet-916	250	24	of	of	ADP
admet-916	250	25	pharmaceutical	pharmaceutical	PROPN
admet-916	250	26	sciences	science	NOUN
admet-916	250	27	27	27	NUM
admet-916	250	28	(	(	PUNCT
admet-916	250	29	2006	2006	NUM
admet-916	250	30	)	)	PUNCT
admet-916	250	31	354	354	NUM
admet-916	250	32	-	-	SYM
admet-916	250	33	362	362	NUM
admet-916	250	34	.	.	PUNCT
admet-916	251	1	https://doi.org/10.1016/	https://doi.org/10.1016/	PROPN
admet-916	251	2	j.ejps.2005.11.005	j.ejps.2005.11.005	PROPN
admet-916	251	3	.	.	PUNCT
admet-916	252	1	[	[	X
admet-916	252	2	16	16	NUM
admet-916	252	3	]	]	PUNCT
admet-916	252	4	a.	a.	NOUN
admet-916	252	5	elezović	elezović	PROPN
admet-916	252	6	,	,	PUNCT
admet-916	252	7	j.	j.	PROPN
admet-916	252	8	hadžiabdić	hadžiabdić	PROPN
admet-916	252	9	,	,	PUNCT
admet-916	252	10	e.	e.	PROPN
admet-916	252	11	vranić	vranić	PROPN
admet-916	252	12	,	,	PUNCT
admet-916	252	13	o.	o.	PROPN
admet-916	252	14	rahić	rahić	PROPN
admet-916	252	15	,	,	PUNCT
admet-916	252	16	a.	a.	NOUN
admet-916	252	17	elezović	elezović	PROPN
admet-916	252	18	(	(	PUNCT
admet-916	252	19	2019	2019	NUM
admet-916	252	20	):	):	PUNCT
admet-916	252	21	pilot	pilot	NOUN
admet-916	252	22	study	study	NOUN
admet-916	252	23	on	on	ADP
admet-916	252	24	variation	variation	NOUN
admet-916	252	25	of	of	ADP
admet-916	252	26	dynamic	dynamic	ADJ
admet-916	252	27	diffusion	diffusion	NOUN
admet-916	252	28	cell	cell	NOUN
admet-916	252	29	artificial	artificial	ADJ
admet-916	252	30	membrane	membrane	NOUN
admet-916	252	31	method	method	NOUN
admet-916	252	32	for	for	ADP
admet-916	252	33	the	the	DET
admet-916	252	34	assessment	assessment	NOUN
admet-916	252	35	of	of	ADP
admet-916	252	36	active	active	ADJ
admet-916	252	37	substances	substance	NOUN
admet-916	252	38	permeability	permeability	NOUN
admet-916	252	39	,	,	PUNCT
admet-916	252	40	research	research	NOUN
admet-916	252	41	journal	journal	NOUN
admet-916	252	42	of	of	ADP
admet-916	252	43	pharmaceutical	pharmaceutical	NOUN
admet-916	252	44	,	,	PUNCT
admet-916	252	45	biological	biological	ADJ
admet-916	252	46	and	and	CCONJ
admet-916	252	47	chemical	chemical	NOUN
admet-916	252	48	sciences	science	NOUN
admet-916	252	49	10	10	NUM
admet-916	252	50	(	(	PUNCT
admet-916	252	51	2019	2019	NUM
admet-916	252	52	)	)	PUNCT
admet-916	252	53	64	64	NUM
admet-916	252	54	-	-	SYM
admet-916	252	55	75	75	NUM
admet-916	252	56	.	.	PUNCT
admet-916	253	1	https://doi.org/10.33887/rjpbcs/2019.10.3.9	https://doi.org/10.33887/rjpbcs/2019.10.3.9	NOUN
admet-916	253	2	.	.	PUNCT
admet-916	254	1	[	[	X
admet-916	254	2	17	17	NUM
admet-916	254	3	]	]	X
admet-916	254	4	international	international	ADJ
admet-916	254	5	council	council	NOUN
admet-916	254	6	for	for	ADP
admet-916	254	7	harmonization	harmonization	NOUN
admet-916	254	8	of	of	ADP
admet-916	254	9	technical	technical	ADJ
admet-916	254	10	requirements	requirement	NOUN
admet-916	254	11	for	for	ADP
admet-916	254	12	pharmaceuticals	pharmaceutical	NOUN
admet-916	254	13	for	for	ADP
admet-916	254	14	human	human	ADJ
admet-916	254	15	use	use	NOUN
admet-916	254	16	:	:	PUNCT
admet-916	254	17	validation	validation	NOUN
admet-916	254	18	of	of	ADP
admet-916	254	19	analytical	analytical	ADJ
admet-916	254	20	procedures	procedure	NOUN
admet-916	254	21	:	:	PUNCT
admet-916	254	22	text	text	NOUN
admet-916	254	23	and	and	CCONJ
admet-916	254	24	methodology	methodology	NOUN
admet-916	254	25	q2(r1	q2(r1	NOUN
admet-916	254	26	)	)	PUNCT
admet-916	254	27	(	(	PUNCT
admet-916	254	28	2005	2005	NUM
admet-916	254	29	)	)	PUNCT
admet-916	254	30	.	.	PUNCT
admet-916	255	1	[	[	X
admet-916	255	2	18	18	NUM
admet-916	255	3	]	]	X
admet-916	255	4	y.	y.	NOUN
admet-916	255	5	tsume	tsume	PROPN
admet-916	255	6	,	,	PUNCT
admet-916	255	7	p.	p.	PROPN
admet-916	255	8	langguth	langguth	NOUN
admet-916	255	9	,	,	PUNCT
admet-916	255	10	a.	a.	PROPN
admet-916	255	11	garcia	garcia	PROPN
admet-916	255	12	-	-	PUNCT
admet-916	255	13	arieta	arieta	PROPN
admet-916	255	14	,	,	PUNCT
admet-916	255	15	g.l	g.l	PROPN
admet-916	255	16	.	.	PROPN
admet-916	255	17	amidon	amidon	PROPN
admet-916	255	18	.	.	PUNCT
admet-916	256	1	in	in	ADP
admet-916	256	2	silico	silico	NOUN
admet-916	256	3	prediction	prediction	NOUN
admet-916	256	4	of	of	ADP
admet-916	256	5	drug	drug	NOUN
admet-916	256	6	dissolution	dissolution	NOUN
admet-916	256	7	and	and	CCONJ
admet-916	256	8	absorption	absorption	NOUN
admet-916	256	9	with	with	ADP
admet-916	256	10	variation	variation	NOUN
admet-916	256	11	in	in	ADP
admet-916	256	12	intestinal	intestinal	ADJ
admet-916	256	13	ph	ph	NOUN
admet-916	256	14	for	for	ADP
admet-916	256	15	bcs	bcs	NOUN
admet-916	256	16	class	class	NOUN
admet-916	256	17	ii	ii	PROPN
admet-916	256	18	weak	weak	ADJ
admet-916	256	19	acid	acid	NOUN
admet-916	256	20	drugs	drug	NOUN
admet-916	256	21	:	:	PUNCT
admet-916	256	22	ibuprofen	ibuprofen	NOUN
admet-916	256	23	and	and	CCONJ
admet-916	256	24	ketoprofen	ketoprofen	PROPN
admet-916	256	25	,	,	PUNCT
admet-916	256	26	biopharmaceutical	biopharmaceutical	NOUN
admet-916	256	27	drug	drug	NOUN
admet-916	256	28	disposition	disposition	NOUN
admet-916	256	29	33	33	NUM
admet-916	256	30	(	(	PUNCT
admet-916	256	31	2012	2012	NUM
admet-916	256	32	)	)	PUNCT
admet-916	256	33	366	366	NUM
admet-916	256	34	-	-	SYM
admet-916	256	35	377	377	NUM
admet-916	256	36	.	.	PUNCT
admet-916	257	1	https://doi.org/10.1002/bdd.1800	https://doi.org/10.1002/bdd.1800	NOUN
admet-916	257	2	.	.	PUNCT
admet-916	258	1	[	[	X
admet-916	258	2	19	19	NUM
admet-916	258	3	]	]	PUNCT
admet-916	258	4	k.	k.	PROPN
admet-916	258	5	sugano	sugano	PROPN
admet-916	258	6	,	,	PUNCT
admet-916	258	7	h.	h.	PROPN
admet-916	258	8	hamada	hamada	PROPN
admet-916	258	9	,	,	PUNCT
admet-916	258	10	m.	m.	PROPN
admet-916	258	11	machida	machida	PROPN
admet-916	258	12	,	,	PUNCT
admet-916	258	13	h.	h.	PROPN
admet-916	258	14	ushio	ushio	PROPN
admet-916	258	15	,	,	PUNCT
admet-916	258	16	k.	k.	PROPN
admet-916	258	17	saitoh	saitoh	PROPN
admet-916	258	18	,	,	PUNCT
admet-916	258	19	k.	k.	PROPN
admet-916	258	20	terada	terada	PROPN
admet-916	258	21	.	.	PROPN
admet-916	259	1	optimized	optimize	VERB
admet-916	259	2	conditions	condition	NOUN
admet-916	259	3	of	of	ADP
admet-916	259	4	biomimetic	biomimetic	ADJ
admet-916	259	5	artificial	artificial	ADJ
admet-916	259	6	membrane	membrane	NOUN
admet-916	259	7	permeation	permeation	NOUN
admet-916	259	8	assay	assay	VERB
admet-916	259	9	,	,	PUNCT
admet-916	259	10	international	international	ADJ
admet-916	259	11	journal	journal	NOUN
admet-916	259	12	of	of	ADP
admet-916	259	13	pharmaceutics	pharmaceutic	NOUN
admet-916	259	14	228	228	NUM
admet-916	259	15	(	(	PUNCT
admet-916	259	16	2001	2001	NUM
admet-916	259	17	)	)	PUNCT
admet-916	259	18	181	181	NUM
admet-916	259	19	-	-	SYM
admet-916	259	20	188	188	NUM
admet-916	259	21	.	.	PUNCT
admet-916	260	1	https://doi.org/10.1016/s0378-5173(01)00845-6	https://doi.org/10.1016/s0378-5173(01)00845-6	PROPN
admet-916	260	2	.	.	PUNCT
admet-916	261	1	[	[	X
admet-916	261	2	20	20	NUM
admet-916	261	3	]	]	X
admet-916	261	4	c.	c.	NOUN
admet-916	261	5	roos	roos	PROPN
admet-916	261	6	,	,	PUNCT
admet-916	261	7	d.	d.	PROPN
admet-916	261	8	dahlgren	dahlgren	PROPN
admet-916	261	9	,	,	PUNCT
admet-916	261	10	e.	e.	PROPN
admet-916	261	11	sjögren	sjögren	PROPN
admet-916	261	12	,	,	PUNCT
admet-916	261	13	c.	c.	PROPN
admet-916	261	14	tannergren	tannergren	PROPN
admet-916	261	15	,	,	PUNCT
admet-916	261	16	b.	b.	PROPN
admet-916	261	17	abrahamsson	abrahamsson	PROPN
admet-916	261	18	,	,	PUNCT
admet-916	261	19	h.	h.	PROPN
admet-916	261	20	lennernäs	lennernäs	PROPN
admet-916	261	21	.	.	PUNCT
admet-916	262	1	regional	regional	ADJ
admet-916	262	2	intestinal	intestinal	ADJ
admet-916	262	3	permeability	permeability	NOUN
admet-916	262	4	in	in	ADP
admet-916	262	5	rats	rat	NOUN
admet-916	262	6	:	:	PUNCT
admet-916	262	7	a	a	DET
admet-916	262	8	comparison	comparison	NOUN
admet-916	262	9	of	of	ADP
admet-916	262	10	methods	method	NOUN
admet-916	262	11	,	,	PUNCT
admet-916	262	12	molecular	molecular	ADJ
admet-916	262	13	pharmaceutics	pharmaceutic	NOUN
admet-916	262	14	14	14	NUM
admet-916	262	15	(	(	PUNCT
admet-916	262	16	2017	2017	NUM
admet-916	262	17	)	)	PUNCT
admet-916	262	18	4252	4252	NUM
admet-916	262	19	-	-	SYM
admet-916	262	20	4261	4261	NUM
admet-916	262	21	.	.	PUNCT
admet-916	263	1	https://doi.org/10.1021/acs.molpharmaceut.7b00279	https://doi.org/10.1021/acs.molpharmaceut.7b00279	NOUN
admet-916	263	2	.	.	PUNCT
admet-916	264	1	[	[	X
admet-916	264	2	21	21	NUM
admet-916	264	3	]	]	X
admet-916	264	4	y.e	y.e	PROPN
admet-916	264	5	.	.	PUNCT
admet-916	264	6	arnold	arnold	PROPN
admet-916	264	7	,	,	PUNCT
admet-916	264	8	j.	j.	PROPN
admet-916	264	9	thorens	thorens	PROPN
admet-916	264	10	,	,	PUNCT
admet-916	264	11	s.	s.	PROPN
admet-916	264	12	bernard	bernard	PROPN
admet-916	264	13	,	,	PUNCT
admet-916	264	14	y.n	y.n	PROPN
admet-916	264	15	.	.	PROPN
admet-916	264	16	kalia	kalia	PROPN
admet-916	264	17	.	.	PUNCT
admet-916	265	1	drug	drug	NOUN
admet-916	265	2	transport	transport	NOUN
admet-916	265	3	across	across	ADP
admet-916	265	4	porcine	porcine	NOUN
admet-916	265	5	intestine	intestine	NOUN
admet-916	265	6	using	use	VERB
admet-916	265	7	an	an	DET
admet-916	265	8	ussing	ussing	ADJ
admet-916	265	9	chamber	chamber	NOUN
admet-916	265	10	system	system	NOUN
admet-916	265	11	:	:	PUNCT
admet-916	265	12	regional	regional	ADJ
admet-916	265	13	differences	difference	NOUN
admet-916	265	14	and	and	CCONJ
admet-916	265	15	the	the	DET
admet-916	265	16	effect	effect	NOUN
admet-916	265	17	of	of	ADP
admet-916	265	18	p	p	NOUN
admet-916	265	19	-	-	PUNCT
admet-916	265	20	glycoprotein	glycoprotein	NOUN
admet-916	265	21	and	and	CCONJ
admet-916	265	22	cyp3a4	cyp3a4	NOUN
admet-916	265	23	activity	activity	NOUN
admet-916	265	24	on	on	ADP
admet-916	265	25	drug	drug	NOUN
admet-916	265	26	absorption	absorption	NOUN
admet-916	265	27	,	,	PUNCT
admet-916	265	28	pharmaceutics	pharmaceutic	NOUN
admet-916	265	29	11	11	NUM
admet-916	265	30	(	(	PUNCT
admet-916	265	31	2019	2019	NUM
admet-916	265	32	)	)	PUNCT
admet-916	265	33	139	139	NUM
admet-916	265	34	.	.	PUNCT
admet-916	266	1	https://doi.org/10.3390/pharmaceutics11030139	https://doi.org/10.3390/pharmaceutics11030139	NOUN
admet-916	266	2	.	.	PUNCT
admet-916	267	1	[	[	X
admet-916	267	2	22	22	NUM
admet-916	267	3	]	]	X
admet-916	267	4	a.j	a.j	PROPN
admet-916	267	5	.	.	PROPN
admet-916	267	6	scheen	scheen	PROPN
admet-916	267	7	.	.	PUNCT
admet-916	268	1	clinical	clinical	ADJ
admet-916	268	2	pharmacokinetics	pharmacokinetic	NOUN
admet-916	268	3	of	of	ADP
admet-916	268	4	metformin	metformin	NOUN
admet-916	268	5	,	,	PUNCT
admet-916	268	6	clinical	clinical	ADJ
admet-916	268	7	pharmacokinetics	pharmacokinetic	NOUN
admet-916	268	8	30	30	NUM
admet-916	268	9	(	(	PUNCT
admet-916	268	10	1996	1996	NUM
admet-916	268	11	)	)	PUNCT
admet-916	268	12	359	359	NUM
admet-916	268	13	-	-	SYM
admet-916	268	14	371	371	NUM
admet-916	268	15	.	.	PUNCT
admet-916	269	1	https://doi.org/10.2165/00003088-199630050-00003	https://doi.org/10.2165/00003088-199630050-00003	NOUN
admet-916	269	2	.	.	PUNCT
admet-916	270	1	[	[	X
admet-916	270	2	23	23	NUM
admet-916	270	3	]	]	X
admet-916	270	4	m.a	m.a	AUX
admet-916	270	5	.	.	PROPN
admet-916	270	6	lassoued	lassoued	PROPN
admet-916	270	7	,	,	PUNCT
admet-916	270	8	f.	f.	PROPN
admet-916	270	9	khemiss	khemiss	PROPN
admet-916	270	10	,	,	PUNCT
admet-916	270	11	s.	s.	PROPN
admet-916	270	12	sfar	sfar	PROPN
admet-916	270	13	.	.	PUNCT
admet-916	271	1	comparative	comparative	ADJ
admet-916	271	2	study	study	NOUN
admet-916	271	3	of	of	ADP
admet-916	271	4	two	two	NUM
admet-916	271	5	in	in	ADP
admet-916	271	6	vitro	vitro	X
admet-916	271	7	methods	method	NOUN
admet-916	271	8	for	for	ADP
admet-916	271	9	assessing	assess	VERB
admet-916	271	10	drug	drug	NOUN
admet-916	271	11	absorption	absorption	NOUN
admet-916	271	12	:	:	PUNCT
admet-916	271	13	sartorius	sartorius	NOUN
admet-916	271	14	sm	sm	PROPN
admet-916	271	15	16750	16750	NUM
admet-916	271	16	apparatus	apparatus	NOUN
admet-916	271	17	versus	versus	ADP
admet-916	271	18	everted	evert	VERB
admet-916	271	19	gut	gut	NOUN
admet-916	271	20	sac	sac	NOUN
admet-916	271	21	,	,	PUNCT
admet-916	271	22	journal	journal	NOUN
admet-916	271	23	of	of	ADP
admet-916	271	24	pharmacy	pharmacy	NOUN
admet-916	271	25	and	and	CCONJ
admet-916	271	26	pharmaceutical	pharmaceutical	NOUN
admet-916	271	27	sciences	science	NOUN
admet-916	271	28	14	14	NUM
admet-916	271	29	(	(	PUNCT
admet-916	271	30	2011	2011	NUM
admet-916	271	31	)	)	PUNCT
admet-916	271	32	117	117	NUM
admet-916	271	33	–	–	PUNCT
admet-916	271	34	127	127	NUM
admet-916	271	35	.	.	PUNCT
admet-916	272	1	https://doi.org/10.18433/j3gc7r	https://doi.org/10.18433/j3gc7r	NOUN
admet-916	272	2	.	.	PUNCT
admet-916	273	1	[	[	X
admet-916	273	2	24	24	NUM
admet-916	273	3	]	]	X
admet-916	273	4	n.n	n.n	PROPN
admet-916	273	5	.	.	PROPN
admet-916	273	6	song	song	PROPN
admet-916	273	7	,	,	PUNCT
admet-916	273	8	q.s	q.s	PROPN
admet-916	273	9	.	.	PROPN
admet-916	273	10	li	li	PROPN
admet-916	273	11	,	,	PUNCT
admet-916	273	12	c.x	c.x	PROPN
admet-916	273	13	.	.	PROPN
admet-916	273	14	liu	liu	PROPN
admet-916	273	15	.	.	PUNCT
admet-916	274	1	intestinal	intestinal	ADJ
admet-916	274	2	permeability	permeability	NOUN
admet-916	274	3	of	of	ADP
admet-916	274	4	metformin	metformin	NOUN
admet-916	274	5	using	use	VERB
admet-916	274	6	single	single	ADJ
admet-916	274	7	-	-	PUNCT
admet-916	274	8	pass	pass	ADJ
admet-916	274	9	intestinal	intestinal	ADJ
admet-916	274	10	perfusion	perfusion	NOUN
admet-916	274	11	in	in	ADP
admet-916	274	12	rats	rat	NOUN
admet-916	274	13	,	,	PUNCT
admet-916	274	14	world	world	NOUN
admet-916	274	15	journal	journal	NOUN
admet-916	274	16	of	of	ADP
admet-916	274	17	gastroenterology	gastroenterology	NOUN
admet-916	274	18	12	12	NUM
admet-916	274	19	(	(	PUNCT
admet-916	274	20	2006	2006	NUM
admet-916	274	21	)	)	PUNCT
admet-916	274	22	4064	4064	NUM
admet-916	274	23	-	-	SYM
admet-916	274	24	4070	4070	NUM
admet-916	274	25	.	.	PUNCT
admet-916	275	1	https://doi.org/10.3748/wjg	https://doi.org/10.3748/wjg	NOUN
admet-916	275	2	.	.	PUNCT
admet-916	275	3	v12.i25.4064	v12.i25.4064	NOUN
admet-916	275	4	.	.	PUNCT
admet-916	276	1	[	[	X
admet-916	276	2	25	25	NUM
admet-916	276	3	]	]	PUNCT
admet-916	276	4	p.	p.	PROPN
admet-916	276	5	nicklin	nicklin	PROPN
admet-916	276	6	,	,	PUNCT
admet-916	276	7	a.c	a.c	PROPN
admet-916	276	8	.	.	PROPN
admet-916	276	9	keates	keates	PROPN
admet-916	276	10	,	,	PUNCT
admet-916	276	11	t.	t.	NOUN
admet-916	276	12	page	page	NOUN
admet-916	276	13	,	,	PUNCT
admet-916	276	14	c.j	c.j	PROPN
admet-916	276	15	.	.	PROPN
admet-916	276	16	bailey	bailey	PROPN
admet-916	276	17	.	.	PUNCT
admet-916	277	1	transfer	transfer	NOUN
admet-916	277	2	of	of	ADP
admet-916	277	3	metformin	metformin	NOUN
admet-916	277	4	across	across	ADP
admet-916	277	5	monolayers	monolayer	NOUN
admet-916	277	6	of	of	ADP
admet-916	277	7	human	human	ADJ
admet-916	277	8	intestinal	intestinal	ADJ
admet-916	277	9	caco-2	caco-2	NUM
admet-916	277	10	cells	cell	NOUN
admet-916	277	11	and	and	CCONJ
admet-916	277	12	across	across	ADP
admet-916	277	13	rat	rat	NOUN
admet-916	277	14	intestine	intestine	NOUN
admet-916	277	15	,	,	PUNCT
admet-916	277	16	international	international	ADJ
admet-916	277	17	journal	journal	NOUN
admet-916	277	18	of	of	ADP
admet-916	277	19	pharmaceutics	pharmaceutic	NOUN
admet-916	277	20	128	128	NUM
admet-916	277	21	(	(	PUNCT
admet-916	277	22	1996	1996	NUM
admet-916	277	23	)	)	PUNCT
admet-916	278	1	155–162	155–162	NUM
admet-916	278	2	.	.	PUNCT
admet-916	279	1	https://doi.org/10.1016/0378-5173(95)04259-8	https://doi.org/10.1016/0378-5173(95)04259-8	NOUN
admet-916	279	2	.	.	PUNCT
admet-916	280	1	[	[	X
admet-916	280	2	26	26	NUM
admet-916	280	3	]	]	X
admet-916	280	4	w.r	w.r	PROPN
admet-916	280	5	.	.	NOUN
admet-916	280	6	proctor	proctor	PROPN
admet-916	280	7	,	,	PUNCT
admet-916	280	8	d.l	d.l	PROPN
admet-916	280	9	.	.	PROPN
admet-916	280	10	bourdet	bourdet	PROPN
admet-916	280	11	,	,	PUNCT
admet-916	280	12	d.r	d.r	PROPN
admet-916	280	13	.	.	PROPN
admet-916	280	14	thakker	thakker	PROPN
admet-916	280	15	.	.	PUNCT
admet-916	281	1	mechanisms	mechanism	NOUN
admet-916	281	2	underlying	underlie	VERB
admet-916	281	3	saturable	saturable	ADJ
admet-916	281	4	intestinal	intestinal	ADJ
admet-916	281	5	absorption	absorption	NOUN
admet-916	281	6	of	of	ADP
admet-916	281	7	metformin	metformin	NOUN
admet-916	281	8	,	,	PUNCT
admet-916	281	9	drug	drug	NOUN
admet-916	281	10	metabolism	metabolism	NOUN
admet-916	281	11	and	and	CCONJ
admet-916	281	12	disposition	disposition	NOUN
admet-916	281	13	36	36	NUM
admet-916	281	14	(	(	PUNCT
admet-916	281	15	2008	2008	NUM
admet-916	281	16	)	)	PUNCT
admet-916	281	17	1650	1650	NUM
admet-916	281	18	-	-	SYM
admet-916	281	19	1658	1658	NUM
admet-916	281	20	.	.	PUNCT
admet-916	282	1	https://doi	https://doi	PROPN
admet-916	282	2	.	.	PUNCT
admet-916	282	3	org/10.1124	org/10.1124	PROPN
admet-916	282	4	/	/	SYM
admet-916	282	5	dmd.107.020180	dmd.107.020180	PROPN
admet-916	282	6	.	.	PUNCT
admet-916	283	1	[	[	X
admet-916	283	2	27	27	NUM
admet-916	283	3	]	]	X
admet-916	283	4	g.g	g.g	PROPN
admet-916	283	5	.	.	PROPN
admet-916	283	6	graham	graham	PROPN
admet-916	283	7	,	,	PUNCT
admet-916	283	8	j.	j.	PROPN
admet-916	283	9	punt	punt	PROPN
admet-916	283	10	,	,	PUNCT
admet-916	283	11	m.	m.	NOUN
admet-916	283	12	arora	arora	PROPN
admet-916	283	13	,	,	PUNCT
admet-916	283	14	r.o	r.o	PROPN
admet-916	283	15	.	.	PROPN
admet-916	283	16	day	day	PROPN
admet-916	283	17	,	,	PUNCT
admet-916	283	18	m.p	m.p	PROPN
admet-916	283	19	.	.	PROPN
admet-916	283	20	doogue	doogue	PROPN
admet-916	283	21	,	,	PUNCT
admet-916	283	22	j.k	j.k	PROPN
admet-916	283	23	.	.	PROPN
admet-916	283	24	duong	duong	PROPN
admet-916	283	25	,	,	PUNCT
admet-916	283	26	t.j	t.j	PROPN
admet-916	283	27	.	.	PROPN
admet-916	283	28	furlong	furlong	PROPN
admet-916	283	29	,	,	PUNCT
admet-916	283	30	j.r	j.r	PROPN
admet-916	283	31	.	.	PROPN
admet-916	283	32	greenfield	greenfield	PROPN
admet-916	283	33	,	,	PUNCT
admet-916	283	34	l.c	l.c	PROPN
admet-916	283	35	.	.	PROPN
admet-916	283	36	greenup	greenup	PROPN
admet-916	283	37	,	,	PUNCT
admet-916	283	38	c.m	c.m	PROPN
admet-916	283	39	.	.	PROPN
admet-916	283	40	kirkpatrick	kirkpatrick	PROPN
admet-916	283	41	,	,	PUNCT
admet-916	283	42	j.e	j.e	PROPN
admet-916	283	43	.	.	PROPN
admet-916	283	44	ray	ray	PROPN
admet-916	283	45	,	,	PUNCT
admet-916	283	46	p.	p.	PROPN
admet-916	283	47	timmins	timmins	PROPN
admet-916	283	48	,	,	PUNCT
admet-916	283	49	k.m	k.m	PROPN
admet-916	283	50	.	.	PROPN
admet-916	283	51	williams	williams	PROPN
admet-916	283	52	.	.	PUNCT
admet-916	284	1	clinical	clinical	ADJ
admet-916	284	2	pharmacokinetics	pharmacokinetic	NOUN
admet-916	284	3	of	of	ADP
admet-916	284	4	metformin	metformin	NOUN
admet-916	284	5	,	,	PUNCT
admet-916	284	6	clinical	clinical	ADJ
admet-916	284	7	pharmacokinetics	pharmacokinetic	NOUN
admet-916	284	8	50	50	NUM
admet-916	284	9	(	(	PUNCT
admet-916	284	10	2011	2011	NUM
admet-916	284	11	)	)	PUNCT
admet-916	284	12	81–98	81–98	NUM
admet-916	284	13	.	.	PUNCT
admet-916	285	1	https://doi.org/10.2165/11534750000000000-00000	https://doi.org/10.2165/11534750000000000-00000	NUM
admet-916	285	2	.	.	PUNCT
admet-916	286	1	[	[	X
admet-916	286	2	28	28	NUM
admet-916	286	3	]	]	X
admet-916	286	4	j.	j.	PROPN
admet-916	286	5	karlsson	karlsson	PROPN
admet-916	286	6	,	,	PUNCT
admet-916	286	7	p.	p.	PROPN
admet-916	286	8	artursson	artursson	PROPN
admet-916	286	9	.	.	PUNCT
admet-916	287	1	a	a	DET
admet-916	287	2	method	method	NOUN
admet-916	287	3	for	for	ADP
admet-916	287	4	the	the	DET
admet-916	287	5	determination	determination	NOUN
admet-916	287	6	of	of	ADP
admet-916	287	7	cellular	cellular	ADJ
admet-916	287	8	permeability	permeability	NOUN
admet-916	287	9	coefficients	coefficient	NOUN
admet-916	287	10	and	and	CCONJ
admet-916	287	11	aqueous	aqueous	ADJ
admet-916	287	12	boundary	boundary	ADJ
admet-916	287	13	layer	layer	NOUN
admet-916	287	14	thickness	thickness	NOUN
admet-916	287	15	in	in	ADP
admet-916	287	16	monolayers	monolayer	NOUN
admet-916	287	17	of	of	ADP
admet-916	287	18	intestinal	intestinal	ADJ
admet-916	287	19	epithelial	epithelial	ADJ
admet-916	287	20	(	(	PUNCT
admet-916	287	21	caco-2	caco-2	NOUN
admet-916	287	22	)	)	PUNCT
admet-916	287	23	cells	cell	NOUN
admet-916	287	24	grown	grow	VERB
admet-916	287	25	in	in	ADP
admet-916	287	26	permeable	permeable	ADJ
admet-916	287	27	filter	filter	NOUN
admet-916	287	28	chambers	chamber	NOUN
admet-916	287	29	,	,	PUNCT
admet-916	287	30	international	international	ADJ
admet-916	287	31	journal	journal	NOUN
admet-916	287	32	of	of	ADP
admet-916	287	33	pharmaceutics	pharmaceutic	NOUN
admet-916	287	34	71	71	NUM
admet-916	287	35	(	(	PUNCT
admet-916	287	36	1991	1991	NUM
admet-916	287	37	)	)	PUNCT
admet-916	287	38	55	55	NUM
admet-916	287	39	-	-	SYM
admet-916	287	40	64	64	NUM
admet-916	287	41	.	.	PUNCT
admet-916	288	1	https://doi.org/10.1016/0378-5173(91)90067-x	https://doi.org/10.1016/0378-5173(91)90067-x	PROPN
admet-916	288	2	.	.	PUNCT
admet-916	289	1	©	©	PROPN
admet-916	289	2	2021	2021	NUM
admet-916	289	3	by	by	ADP
admet-916	289	4	the	the	DET
admet-916	289	5	authors	author	NOUN
admet-916	289	6	;	;	PUNCT
admet-916	289	7	licensee	licensee	PROPN
admet-916	289	8	iapc	iapc	PROPN
admet-916	289	9	,	,	PUNCT
admet-916	289	10	zagreb	zagreb	PROPN
admet-916	289	11	,	,	PUNCT
admet-916	289	12	croatia	croatia	PROPN
admet-916	289	13	.	.	PUNCT
admet-916	290	1	this	this	DET
admet-916	290	2	article	article	NOUN
admet-916	290	3	is	be	AUX
admet-916	290	4	an	an	DET
admet-916	290	5	open	open	ADJ
admet-916	290	6	-	-	PUNCT
admet-916	290	7	access	access	NOUN
admet-916	290	8	article	article	NOUN
admet-916	290	9	distributed	distribute	VERB
admet-916	290	10	under	under	ADP
admet-916	290	11	the	the	DET
admet-916	290	12	terms	term	NOUN
admet-916	290	13	and	and	CCONJ
admet-916	290	14	conditions	condition	NOUN
admet-916	290	15	of	of	ADP
admet-916	290	16	the	the	DET
admet-916	290	17	creative	creative	ADJ
admet-916	290	18	commons	common	NOUN
admet-916	290	19	attribution	attribution	NOUN
admet-916	290	20	license	license	NOUN
admet-916	290	21	(	(	PUNCT
admet-916	290	22	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
admet-916	290	23	)	)	PUNCT
admet-916	290	24	https://doi.org/10.1016/j.ejps.2005.11.005	https://doi.org/10.1016/j.ejps.2005.11.005	PROPN
admet-916	290	25	https://doi.org/10.1016/j.ejps.2005.11.005	https://doi.org/10.1016/j.ejps.2005.11.005	NUM
admet-916	290	26	https://doi.org/10.33887/rjpbcs/2019.10.3.9	https://doi.org/10.33887/rjpbcs/2019.10.3.9	PROPN
admet-916	290	27	https://doi.org/10.1002/bdd.1800	https://doi.org/10.1002/bdd.1800	PROPN
admet-916	290	28	https://doi.org/10.1016/s0378-5173(01)00845-6	https://doi.org/10.1016/s0378-5173(01)00845-6	PROPN
admet-916	290	29	https://doi.org/10.1021/acs.molpharmaceut.7b00279	https://doi.org/10.1021/acs.molpharmaceut.7b00279	ADV
admet-916	290	30	https://doi.org/10.3390/pharmaceutics11030139	https://doi.org/10.3390/pharmaceutics11030139	ADJ
admet-916	290	31	https://doi.org/10.2165/00003088-199630050-00003	https://doi.org/10.2165/00003088-199630050-00003	NOUN
admet-916	290	32	https://doi.org/10.18433/j3gc7r	https://doi.org/10.18433/j3gc7r	NOUN
admet-916	290	33	https://dx.doi.org/10.3748%2fwjg.v12.i25.4064	https://dx.doi.org/10.3748%2fwjg.v12.i25.4064	PROPN
admet-916	290	34	https://dx.doi.org/10.3748%2fwjg.v12.i25.4064	https://dx.doi.org/10.3748%2fwjg.v12.i25.4064	PROPN
admet-916	290	35	https://doi.org/10.1016/0378-5173(95)04259-8	https://doi.org/10.1016/0378-5173(95)04259-8	PUNCT
admet-916	290	36	https://doi.org/10.1124/dmd.107.020180	https://doi.org/10.1124/dmd.107.020180	PRON
admet-916	291	1	https://doi.org/10.2165/11534750-000000000-00000	https://doi.org/10.2165/11534750-000000000-00000	ADJ
admet-916	291	2	https://doi.org/10.2165/11534750-000000000-00000	https://doi.org/10.2165/11534750-000000000-00000	INTJ
admet-916	291	3	https://doi.org/10.1016/0378-5173(91)90067-x	https://doi.org/10.1016/0378-5173(91)90067-x	PROPN
admet-916	291	4	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN