id	sid	tid	token	lemma	pos
admet-923	1	1	lost	lose	VERB
admet-923	1	2	in	in	ADP
admet-923	1	3	modelling	modelling	NOUN
admet-923	1	4	and	and	CCONJ
admet-923	1	5	simulation	simulation	NOUN
admet-923	1	6	?	?	PUNCT
admet-923	2	1	doi	doi	NOUN
admet-923	2	2	:	:	PUNCT
admet-923	2	3	https:/doi.org/10.5599	https:/doi.org/10.5599	PROPN
admet-923	2	4	/	/	SYM
admet-923	2	5	admet.923	admet.923	PROPN
admet-923	2	6	75	75	NUM
admet-923	2	7	admet	admet	X
admet-923	2	8	&	&	CCONJ
admet-923	2	9	dmpk	dmpk	PROPN
admet-923	2	10	9(2	9(2	NUM
admet-923	2	11	)	)	PUNCT
admet-923	2	12	(	(	PUNCT
admet-923	2	13	2021	2021	NUM
admet-923	2	14	)	)	PUNCT
admet-923	2	15	75	75	NUM
admet-923	2	16	-	-	SYM
admet-923	2	17	109	109	NUM
admet-923	2	18	;	;	PUNCT
admet-923	2	19	doi	doi	NOUN
admet-923	2	20	:	:	PUNCT
admet-923	2	21	https://doi.org/10.5599/admet.923	https://doi.org/10.5599/admet.923	X
admet-923	2	22	open	open	ADJ
admet-923	2	23	access	access	NOUN
admet-923	2	24	:	:	PUNCT
admet-923	2	25	issn	issn	PROPN
admet-923	2	26	:	:	PUNCT
admet-923	2	27	1848	1848	NUM
admet-923	2	28	-	-	SYM
admet-923	2	29	7718	7718	NUM
admet-923	2	30	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-923	2	31	feature	feature	NOUN
admet-923	2	32	article	article	NOUN
admet-923	2	33	lost	lose	VERB
admet-923	2	34	in	in	ADP
admet-923	2	35	modelling	modelling	NOUN
admet-923	2	36	and	and	CCONJ
admet-923	2	37	simulation	simulation	NOUN
admet-923	2	38	?	?	PUNCT
admet-923	3	1	kiyohiko	kiyohiko	PROPN
admet-923	3	2	sugano	sugano	VERB
admet-923	3	3	molecular	molecular	ADJ
admet-923	3	4	pharmaceutics	pharmaceutic	NOUN
admet-923	3	5	lab	lab	NOUN
admet-923	3	6	.	.	PUNCT
admet-923	3	7	,	,	PUNCT
admet-923	3	8	college	college	NOUN
admet-923	3	9	of	of	ADP
admet-923	3	10	pharmaceutical	pharmaceutical	NOUN
admet-923	3	11	sciences	science	NOUN
admet-923	3	12	,	,	PUNCT
admet-923	3	13	ritsumeikan	ritsumeikan	ADJ
admet-923	3	14	university	university	NOUN
admet-923	3	15	,	,	PUNCT
admet-923	3	16	1	1	NUM
admet-923	3	17	-	-	SYM
admet-923	3	18	1	1	NUM
admet-923	3	19	-	-	SYM
admet-923	3	20	1	1	NUM
admet-923	3	21	,	,	PUNCT
admet-923	3	22	noji	noji	NOUN
admet-923	3	23	-	-	PUNCT
admet-923	3	24	higashi	higashi	PROPN
admet-923	3	25	,	,	PUNCT
admet-923	3	26	kusatsu	kusatsu	NOUN
admet-923	3	27	,	,	PUNCT
admet-923	3	28	shiga	shiga	NOUN
admet-923	3	29	525	525	NUM
admet-923	3	30	-	-	SYM
admet-923	3	31	8577	8577	NUM
admet-923	3	32	,	,	PUNCT
admet-923	3	33	japan	japan	PROPN
admet-923	3	34	e	e	PROPN
admet-923	3	35	-	-	NOUN
admet-923	3	36	mail	mail	NOUN
admet-923	3	37	:	:	PUNCT
admet-923	3	38	suganok@fc.ritsumei.ac.jp	suganok@fc.ritsumei.ac.jp	NOUN
admet-923	3	39	;	;	PUNCT
admet-923	3	40	tel	tel	PROPN
admet-923	3	41	.	.	PROPN
admet-923	3	42	:	:	PUNCT
admet-923	4	1	+81	+81	PROPN
admet-923	4	2	-	-	PUNCT
admet-923	4	3	77	77	NUM
admet-923	4	4	-	-	PUNCT
admet-923	4	5	561	561	NUM
admet-923	4	6	-	-	PUNCT
admet-923	4	7	2773	2773	NUM
admet-923	4	8	received	receive	VERB
admet-923	4	9	:	:	PUNCT
admet-923	4	10	november	november	PROPN
admet-923	4	11	06	06	NUM
admet-923	4	12	,	,	PUNCT
admet-923	4	13	2021	2021	NUM
admet-923	4	14	;	;	PUNCT
admet-923	4	15	revised	revise	VERB
admet-923	4	16	:	:	PUNCT
admet-923	4	17	march	march	PROPN
admet-923	4	18	05	05	NUM
admet-923	4	19	,	,	PUNCT
admet-923	4	20	2021	2021	NUM
admet-923	4	21	;	;	PUNCT
admet-923	4	22	published	publish	VERB
admet-923	4	23	:	:	PUNCT
admet-923	4	24	march	march	PROPN
admet-923	4	25	22	22	NUM
admet-923	4	26	,	,	PUNCT
admet-923	4	27	2021	2021	NUM
admet-923	4	28	abstract	abstract	NOUN
admet-923	4	29	over	over	ADP
admet-923	4	30	the	the	DET
admet-923	4	31	past	past	ADJ
admet-923	4	32	few	few	ADJ
admet-923	4	33	decades	decade	NOUN
admet-923	4	34	,	,	PUNCT
admet-923	4	35	physiologically	physiologically	ADV
admet-923	4	36	-	-	PUNCT
admet-923	4	37	based	base	VERB
admet-923	4	38	pharmacokinetic	pharmacokinetic	ADJ
admet-923	4	39	modelling	modelling	NOUN
admet-923	4	40	(	(	PUNCT
admet-923	4	41	pbpk	pbpk	NOUN
admet-923	4	42	)	)	PUNCT
admet-923	4	43	has	have	AUX
admet-923	4	44	been	be	AUX
admet-923	4	45	anticipated	anticipate	VERB
admet-923	4	46	to	to	PART
admet-923	4	47	be	be	AUX
admet-923	4	48	a	a	DET
admet-923	4	49	powerful	powerful	ADJ
admet-923	4	50	tool	tool	NOUN
admet-923	4	51	to	to	PART
admet-923	4	52	improve	improve	VERB
admet-923	4	53	the	the	DET
admet-923	4	54	productivity	productivity	NOUN
admet-923	4	55	of	of	ADP
admet-923	4	56	drug	drug	NOUN
admet-923	4	57	discovery	discovery	NOUN
admet-923	4	58	and	and	CCONJ
admet-923	4	59	development	development	NOUN
admet-923	4	60	.	.	PUNCT
admet-923	5	1	however	however	ADV
admet-923	5	2	,	,	PUNCT
admet-923	5	3	recently	recently	ADV
admet-923	5	4	,	,	PUNCT
admet-923	5	5	multiple	multiple	ADJ
admet-923	5	6	systematic	systematic	ADJ
admet-923	5	7	evaluation	evaluation	NOUN
admet-923	5	8	studies	study	NOUN
admet-923	5	9	independently	independently	ADV
admet-923	5	10	suggested	suggest	VERB
admet-923	5	11	that	that	SCONJ
admet-923	5	12	the	the	DET
admet-923	5	13	predictive	predictive	ADJ
admet-923	5	14	power	power	NOUN
admet-923	5	15	of	of	ADP
admet-923	5	16	current	current	ADJ
admet-923	5	17	oral	oral	ADJ
admet-923	5	18	absorption	absorption	NOUN
admet-923	5	19	(	(	PUNCT
admet-923	5	20	oa	oa	INTJ
admet-923	5	21	)	)	PUNCT
admet-923	5	22	pbpk	pbpk	NOUN
admet-923	5	23	models	model	NOUN
admet-923	5	24	needs	need	VERB
admet-923	5	25	significant	significant	ADJ
admet-923	5	26	improvement	improvement	NOUN
admet-923	5	27	.	.	PUNCT
admet-923	6	1	there	there	PRON
admet-923	6	2	is	be	VERB
admet-923	6	3	some	some	DET
admet-923	6	4	disagreement	disagreement	NOUN
admet-923	6	5	between	between	ADP
admet-923	6	6	the	the	DET
admet-923	6	7	industry	industry	NOUN
admet-923	6	8	and	and	CCONJ
admet-923	6	9	regulators	regulator	NOUN
admet-923	6	10	about	about	ADP
admet-923	6	11	the	the	DET
admet-923	6	12	credibility	credibility	NOUN
admet-923	6	13	of	of	ADP
admet-923	6	14	oa	oa	PROPN
admet-923	6	15	pbpk	pbpk	PROPN
admet-923	6	16	modelling	modelling	NOUN
admet-923	6	17	.	.	PUNCT
admet-923	7	1	recently	recently	ADV
admet-923	7	2	,	,	PUNCT
admet-923	7	3	the	the	DET
admet-923	7	4	editorial	editorial	ADJ
admet-923	7	5	board	board	NOUN
admet-923	7	6	of	of	ADP
admet-923	7	7	amdet&dmpk	amdet&dmpk	PROPN
admet-923	7	8	has	have	AUX
admet-923	7	9	announced	announce	VERB
admet-923	7	10	the	the	DET
admet-923	7	11	policy	policy	NOUN
admet-923	7	12	for	for	ADP
admet-923	7	13	the	the	DET
admet-923	7	14	articles	article	NOUN
admet-923	7	15	related	relate	VERB
admet-923	7	16	to	to	ADP
admet-923	7	17	pbpk	pbpk	NOUN
admet-923	7	18	modelling	modelling	NOUN
admet-923	7	19	(	(	PUNCT
admet-923	7	20	modelling	modelling	NOUN
admet-923	7	21	and	and	CCONJ
admet-923	7	22	simulation	simulation	NOUN
admet-923	7	23	ethics	ethic	NOUN
admet-923	7	24	)	)	PUNCT
admet-923	7	25	.	.	PUNCT
admet-923	8	1	in	in	ADP
admet-923	8	2	this	this	DET
admet-923	8	3	feature	feature	NOUN
admet-923	8	4	article	article	NOUN
admet-923	8	5	,	,	PUNCT
admet-923	8	6	the	the	DET
admet-923	8	7	background	background	NOUN
admet-923	8	8	of	of	ADP
admet-923	8	9	this	this	DET
admet-923	8	10	policy	policy	NOUN
admet-923	8	11	is	be	AUX
admet-923	8	12	explained	explain	VERB
admet-923	8	13	:	:	PUNCT
admet-923	8	14	(	(	PUNCT
admet-923	8	15	1	1	X
admet-923	8	16	)	)	PUNCT
admet-923	8	17	requirements	requirement	NOUN
admet-923	8	18	for	for	ADP
admet-923	8	19	scientific	scientific	ADJ
admet-923	8	20	writing	writing	NOUN
admet-923	8	21	of	of	ADP
admet-923	8	22	pbpk	pbpk	NOUN
admet-923	8	23	modelling	modelling	NOUN
admet-923	8	24	,	,	PUNCT
admet-923	8	25	(	(	PUNCT
admet-923	8	26	2	2	X
admet-923	8	27	)	)	PUNCT
admet-923	8	28	scientific	scientific	ADJ
admet-923	8	29	literacy	literacy	NOUN
admet-923	8	30	for	for	ADP
admet-923	8	31	pbpk	pbpk	NOUN
admet-923	8	32	modelling	modelling	NOUN
admet-923	8	33	,	,	PUNCT
admet-923	8	34	and	and	CCONJ
admet-923	8	35	(	(	PUNCT
admet-923	8	36	3	3	X
admet-923	8	37	)	)	PUNCT
admet-923	8	38	middle	middle	NOUN
admet-923	8	39	-	-	PUNCT
admet-923	8	40	out	out	ADP
admet-923	8	41	approaches	approach	NOUN
admet-923	8	42	.	.	PUNCT
admet-923	9	1	pbpk	pbpk	NOUN
admet-923	9	2	models	model	NOUN
admet-923	9	3	are	be	AUX
admet-923	9	4	a	a	DET
admet-923	9	5	useful	useful	ADJ
admet-923	9	6	tool	tool	NOUN
admet-923	9	7	if	if	SCONJ
admet-923	9	8	used	use	VERB
admet-923	9	9	correctly	correctly	ADV
admet-923	9	10	.	.	PUNCT
admet-923	10	1	this	this	DET
admet-923	10	2	article	article	NOUN
admet-923	10	3	will	will	AUX
admet-923	10	4	hopefully	hopefully	ADV
admet-923	10	5	help	help	VERB
admet-923	10	6	advance	advance	VERB
admet-923	10	7	the	the	DET
admet-923	10	8	science	science	NOUN
admet-923	10	9	of	of	ADP
admet-923	10	10	oa	oa	PROPN
admet-923	10	11	pbpk	pbpk	PROPN
admet-923	10	12	models	model	NOUN
admet-923	10	13	.	.	PUNCT
admet-923	11	1	©	©	NOUN
admet-923	11	2	2021	2021	NUM
admet-923	11	3	by	by	ADP
admet-923	11	4	the	the	DET
admet-923	11	5	authors	author	NOUN
admet-923	11	6	.	.	PUNCT
admet-923	12	1	this	this	DET
admet-923	12	2	article	article	NOUN
admet-923	12	3	is	be	AUX
admet-923	12	4	an	an	DET
admet-923	12	5	open	open	ADJ
admet-923	12	6	-	-	PUNCT
admet-923	12	7	access	access	NOUN
admet-923	12	8	article	article	NOUN
admet-923	12	9	distributed	distribute	VERB
admet-923	12	10	under	under	ADP
admet-923	12	11	the	the	DET
admet-923	12	12	terms	term	NOUN
admet-923	12	13	and	and	CCONJ
admet-923	12	14	conditions	condition	NOUN
admet-923	12	15	of	of	ADP
admet-923	12	16	the	the	DET
admet-923	12	17	creative	creative	ADJ
admet-923	12	18	commons	common	NOUN
admet-923	12	19	attribution	attribution	NOUN
admet-923	12	20	license	license	NOUN
admet-923	12	21	(	(	PUNCT
admet-923	12	22	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-923	12	23	)	)	PUNCT
admet-923	12	24	.	.	PUNCT
admet-923	13	1	keywords	keyword	NOUN
admet-923	13	2	physiologically	physiologically	ADV
admet-923	13	3	-	-	PUNCT
admet-923	13	4	based	base	VERB
admet-923	13	5	pharmacokinetic	pharmacokinetic	ADJ
admet-923	13	6	modelling	modelling	NOUN
admet-923	13	7	;	;	PUNCT
admet-923	13	8	scientific	scientific	ADJ
admet-923	13	9	literacy	literacy	NOUN
admet-923	13	10	;	;	PUNCT
admet-923	13	11	transparency	transparency	NOUN
admet-923	13	12	;	;	PUNCT
admet-923	13	13	reproducibility	reproducibility	NOUN
admet-923	13	14	;	;	PUNCT
admet-923	13	15	middleout	middleout	NOUN
admet-923	13	16	approach	approach	NOUN
admet-923	13	17	;	;	PUNCT
admet-923	13	18	structural	structural	ADJ
admet-923	13	19	identifiability	identifiability	NOUN
admet-923	13	20	introduction	introduction	NOUN
admet-923	13	21	over	over	ADP
admet-923	13	22	the	the	DET
admet-923	13	23	past	past	ADJ
admet-923	13	24	few	few	ADJ
admet-923	13	25	decades	decade	NOUN
admet-923	13	26	,	,	PUNCT
admet-923	13	27	physiologically	physiologically	ADV
admet-923	13	28	-	-	PUNCT
admet-923	13	29	based	base	VERB
admet-923	13	30	pharmacokinetic	pharmacokinetic	ADJ
admet-923	13	31	modelling	modelling	NOUN
admet-923	13	32	(	(	PUNCT
admet-923	13	33	pbpk	pbpk	NOUN
admet-923	13	34	)	)	PUNCT
admet-923	13	35	has	have	AUX
admet-923	13	36	been	be	AUX
admet-923	13	37	anticipated	anticipate	VERB
admet-923	13	38	to	to	PART
admet-923	13	39	be	be	AUX
admet-923	13	40	a	a	DET
admet-923	13	41	powerful	powerful	ADJ
admet-923	13	42	tool	tool	NOUN
admet-923	13	43	to	to	PART
admet-923	13	44	improve	improve	VERB
admet-923	13	45	the	the	DET
admet-923	13	46	productivity	productivity	NOUN
admet-923	13	47	of	of	ADP
admet-923	13	48	drug	drug	NOUN
admet-923	13	49	discovery	discovery	NOUN
admet-923	13	50	and	and	CCONJ
admet-923	13	51	development	development	NOUN
admet-923	13	52	.	.	PUNCT
admet-923	14	1	several	several	ADJ
admet-923	14	2	sophisticated	sophisticated	ADJ
admet-923	14	3	software	software	NOUN
admet-923	14	4	products	product	NOUN
admet-923	14	5	have	have	AUX
admet-923	14	6	been	be	AUX
admet-923	14	7	commercialized	commercialize	VERB
admet-923	14	8	since	since	SCONJ
admet-923	14	9	the	the	DET
admet-923	14	10	late	late	ADJ
admet-923	14	11	1990s	1990	NOUN
admet-923	14	12	.	.	PUNCT
admet-923	15	1	plenty	plenty	NOUN
admet-923	15	2	of	of	ADP
admet-923	15	3	case	case	NOUN
admet-923	15	4	study	study	NOUN
admet-923	15	5	reports	report	NOUN
admet-923	15	6	have	have	AUX
admet-923	15	7	been	be	AUX
admet-923	15	8	published	publish	VERB
admet-923	15	9	in	in	ADP
admet-923	15	10	peer	peer	NOUN
admet-923	15	11	-	-	PUNCT
admet-923	15	12	reviewed	review	VERB
admet-923	15	13	journals	journal	NOUN
admet-923	15	14	,	,	PUNCT
admet-923	15	15	showing	show	VERB
admet-923	15	16	nearly	nearly	ADV
admet-923	15	17	perfect	perfect	ADJ
admet-923	15	18	prediction	prediction	NOUN
admet-923	15	19	,	,	PUNCT
admet-923	15	20	prediction	prediction	NOUN
admet-923	15	21	error	error	NOUN
admet-923	15	22	being	be	AUX
admet-923	15	23	much	much	ADV
admet-923	15	24	smaller	small	ADJ
admet-923	15	25	than	than	ADP
admet-923	15	26	the	the	DET
admet-923	15	27	variation	variation	NOUN
admet-923	15	28	in	in	ADP
admet-923	15	29	the	the	DET
admet-923	15	30	clinical	clinical	ADJ
admet-923	15	31	plasma	plasma	NOUN
admet-923	15	32	concentration	concentration	NOUN
admet-923	15	33	(	(	PUNCT
admet-923	15	34	cp	cp	NOUN
admet-923	15	35	)	)	PUNCT
admet-923	15	36	time	time	NOUN
admet-923	15	37	profile	profile	NOUN
admet-923	15	38	.	.	PUNCT
admet-923	16	1	it	it	PRON
admet-923	16	2	seems	seem	VERB
admet-923	16	3	that	that	SCONJ
admet-923	16	4	we	we	PRON
admet-923	16	5	already	already	ADV
admet-923	16	6	have	have	AUX
admet-923	16	7	achieved	achieve	VERB
admet-923	16	8	a	a	DET
admet-923	16	9	“	"	PUNCT
admet-923	16	10	prediction	prediction	NOUN
admet-923	16	11	paradise”[1	paradise”[1	NOUN
admet-923	16	12	]	]	X
admet-923	16	13	.	.	PUNCT
admet-923	17	1	…	…	PUNCT
admet-923	17	2	really	really	ADV
admet-923	17	3	?	?	PUNCT
admet-923	18	1	recently	recently	ADV
admet-923	18	2	,	,	PUNCT
admet-923	18	3	multiple	multiple	ADJ
admet-923	18	4	systematic	systematic	ADJ
admet-923	18	5	evaluation	evaluation	NOUN
admet-923	18	6	studies	study	NOUN
admet-923	18	7	independently	independently	ADV
admet-923	18	8	suggested	suggest	VERB
admet-923	18	9	that	that	SCONJ
admet-923	18	10	the	the	DET
admet-923	18	11	“	"	PUNCT
admet-923	18	12	bottom	bottom	ADJ
admet-923	18	13	-	-	PUNCT
admet-923	18	14	up	up	ADP
admet-923	18	15	”	"	PUNCT
admet-923	18	16	predictive	predictive	ADJ
admet-923	18	17	power	power	NOUN
admet-923	18	18	of	of	ADP
admet-923	18	19	current	current	ADJ
admet-923	18	20	oral	oral	ADJ
admet-923	18	21	absorption	absorption	NOUN
admet-923	18	22	(	(	PUNCT
admet-923	18	23	oa	oa	INTJ
admet-923	18	24	)	)	PUNCT
admet-923	18	25	pbpk	pbpk	NOUN
admet-923	18	26	models	model	NOUN
admet-923	18	27	needs	need	VERB
admet-923	18	28	significant	significant	ADJ
admet-923	18	29	improvement	improvement	NOUN
admet-923	18	30	[	[	X
admet-923	18	31	2–6	2–6	NOUN
admet-923	18	32	]	]	X
admet-923	18	33	.	.	PUNCT
admet-923	19	1	almost	almost	ADV
admet-923	19	2	all	all	DET
admet-923	19	3	case	case	NOUN
admet-923	19	4	studies	study	NOUN
admet-923	19	5	had	have	VERB
admet-923	19	6	to	to	PART
admet-923	19	7	use	use	VERB
admet-923	19	8	parameter	parameter	NOUN
admet-923	19	9	optimization	optimization	NOUN
admet-923	19	10	on	on	ADP
admet-923	19	11	a	a	DET
admet-923	19	12	drug	drug	NOUN
admet-923	19	13	-	-	PUNCT
admet-923	19	14	by	by	ADP
admet-923	19	15	-	-	PUNCT
admet-923	19	16	drug	drug	NOUN
admet-923	19	17	basis	basis	NOUN
admet-923	19	18	to	to	PART
admet-923	19	19	fit	fit	VERB
admet-923	19	20	the	the	DET
admet-923	19	21	simulated	simulated	ADJ
admet-923	19	22	plasma	plasma	NOUN
admet-923	19	23	concentration	concentration	NOUN
admet-923	19	24	(	(	PUNCT
admet-923	19	25	cp	cp	NOUN
admet-923	19	26	)	)	PUNCT
admet-923	19	27	time	time	NOUN
admet-923	19	28	curve	curve	NOUN
admet-923	19	29	to	to	ADP
admet-923	19	30	clinical	clinical	ADJ
admet-923	19	31	data	datum	NOUN
admet-923	19	32	(	(	PUNCT
admet-923	19	33	part	part	NOUN
admet-923	19	34	3	3	NUM
admet-923	19	35	,	,	PUNCT
admet-923	19	36	section	section	NOUN
admet-923	19	37	3.4	3.4	NUM
admet-923	19	38	)	)	PUNCT
admet-923	19	39	.	.	PUNCT
admet-923	20	1	expert	expert	NOUN
admet-923	20	2	scientists	scientist	NOUN
admet-923	20	3	continue	continue	VERB
admet-923	20	4	hard	hard	ADJ
admet-923	20	5	experimental	experimental	ADJ
admet-923	20	6	works	work	NOUN
admet-923	20	7	to	to	PART
admet-923	20	8	better	well	ADV
admet-923	20	9	understand	understand	VERB
admet-923	20	10	in	in	ADP
admet-923	20	11	vivo	vivo	NOUN
admet-923	20	12	systems	system	NOUN
admet-923	20	13	and	and	CCONJ
admet-923	20	14	improve	improve	VERB
admet-923	20	15	the	the	DET
admet-923	20	16	predictive	predictive	ADJ
admet-923	20	17	performance	performance	NOUN
admet-923	20	18	of	of	ADP
admet-923	20	19	in	in	ADP
admet-923	20	20	vitro	vitro	X
admet-923	20	21	systems	system	NOUN
admet-923	20	22	[	[	X
admet-923	20	23	7–9	7–9	X
admet-923	20	24	]	]	X
admet-923	20	25	.	.	PUNCT
admet-923	21	1	there	there	PRON
admet-923	21	2	is	be	VERB
admet-923	21	3	some	some	DET
admet-923	21	4	disagreement	disagreement	NOUN
admet-923	21	5	between	between	ADP
admet-923	21	6	the	the	DET
admet-923	21	7	industry	industry	NOUN
admet-923	21	8	and	and	CCONJ
admet-923	21	9	regulators	regulator	NOUN
admet-923	21	10	about	about	ADP
admet-923	21	11	the	the	DET
admet-923	21	12	credibility	credibility	NOUN
admet-923	21	13	of	of	ADP
admet-923	21	14	pbpk	pbpk	NOUN
admet-923	21	15	modelling	model	VERB
admet-923	21	16	[	[	X
admet-923	21	17	10,11	10,11	NOUN
admet-923	21	18	]	]	PUNCT
admet-923	21	19	.	.	PUNCT
admet-923	22	1	"	"	PUNCT
admet-923	22	2	publication	publication	NOUN
admet-923	22	3	bias	bias	NOUN
admet-923	22	4	"	"	PUNCT
admet-923	22	5	(	(	PUNCT
admet-923	22	6	part	part	NOUN
admet-923	22	7	2	2	NUM
admet-923	22	8	,	,	PUNCT
admet-923	22	9	section	section	NOUN
admet-923	22	10	2.4	2.4	NUM
admet-923	22	11	)	)	PUNCT
admet-923	22	12	and	and	CCONJ
admet-923	22	13	"	"	PUNCT
admet-923	22	14	parameter	parameter	NOUN
admet-923	22	15	optimization	optimization	NOUN
admet-923	22	16	"	"	PUNCT
admet-923	22	17	(	(	PUNCT
admet-923	22	18	part	part	NOUN
admet-923	22	19	3	3	NUM
admet-923	22	20	)	)	PUNCT
admet-923	22	21	have	have	AUX
admet-923	22	22	been	be	AUX
admet-923	22	23	identified	identify	VERB
admet-923	22	24	as	as	ADP
admet-923	22	25	the	the	DET
admet-923	22	26	main	main	ADJ
admet-923	22	27	issues	issue	NOUN
admet-923	22	28	of	of	ADP
admet-923	22	29	the	the	DET
admet-923	22	30	https://doi.org/10.5599/admet.923	https://doi.org/10.5599/admet.923	ADJ
admet-923	22	31	https://doi.org/10.5599/admet.923	https://doi.org/10.5599/admet.923	X
admet-923	22	32	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-923	22	33	mailto:suganok@fc.ritsumei.ac.jp	mailto:suganok@fc.ritsumei.ac.jp	PROPN
admet-923	22	34	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-923	22	35	kiyohiko	kiyohiko	PROPN
admet-923	22	36	sugano	sugano	PROPN
admet-923	22	37	admet	admet	PROPN
admet-923	22	38	&	&	CCONJ
admet-923	22	39	dmpk	dmpk	PROPN
admet-923	22	40	9(2	9(2	NUM
admet-923	22	41	)	)	PUNCT
admet-923	22	42	(	(	PUNCT
admet-923	22	43	2021	2021	NUM
admet-923	22	44	)	)	PUNCT
admet-923	22	45	75	75	NUM
admet-923	22	46	-	-	SYM
admet-923	22	47	109	109	NUM
admet-923	22	48	76	76	NUM
admet-923	22	49	case	case	NOUN
admet-923	22	50	studies	study	NOUN
admet-923	22	51	[	[	X
admet-923	22	52	11	11	NUM
admet-923	22	53	]	]	PUNCT
admet-923	22	54	.	.	PUNCT
admet-923	23	1	recently	recently	ADV
admet-923	23	2	,	,	PUNCT
admet-923	23	3	a	a	DET
admet-923	23	4	more	more	ADV
admet-923	23	5	realistic	realistic	ADJ
admet-923	23	6	view	view	NOUN
admet-923	23	7	about	about	ADP
admet-923	23	8	pbpk	pbpk	NOUN
admet-923	23	9	modelling	modelling	NOUN
admet-923	23	10	has	have	AUX
admet-923	23	11	been	be	AUX
admet-923	23	12	reported	report	VERB
admet-923	23	13	by	by	ADP
admet-923	23	14	an	an	DET
admet-923	23	15	industrial	industrial	ADJ
admet-923	23	16	consortium	consortium	NOUN
admet-923	23	17	[	[	X
admet-923	23	18	12	12	NUM
admet-923	23	19	]	]	PUNCT
admet-923	23	20	.	.	PUNCT
admet-923	24	1	are	be	AUX
admet-923	24	2	we	we	PRON
admet-923	24	3	lost	lose	VERB
admet-923	24	4	in	in	ADP
admet-923	24	5	modelling	modelling	NOUN
admet-923	24	6	and	and	CCONJ
admet-923	24	7	simulation	simulation	NOUN
admet-923	24	8	?	?	PUNCT
admet-923	25	1	recently	recently	ADV
admet-923	25	2	,	,	PUNCT
admet-923	25	3	the	the	DET
admet-923	25	4	editorial	editorial	ADJ
admet-923	25	5	board	board	NOUN
admet-923	25	6	of	of	ADP
admet-923	25	7	amdet	amdet	PROPN
admet-923	25	8	and	and	CCONJ
admet-923	25	9	dmpk	dmpk	NOUN
admet-923	25	10	has	have	AUX
admet-923	25	11	announced	announce	VERB
admet-923	25	12	the	the	DET
admet-923	25	13	policy	policy	NOUN
admet-923	25	14	for	for	ADP
admet-923	25	15	the	the	DET
admet-923	25	16	articles	article	NOUN
admet-923	25	17	related	relate	VERB
admet-923	25	18	to	to	ADP
admet-923	25	19	pbpk	pbpk	NOUN
admet-923	25	20	modelling	modelling	NOUN
admet-923	25	21	(	(	PUNCT
admet-923	25	22	modelling	modelling	NOUN
admet-923	25	23	and	and	CCONJ
admet-923	25	24	simulation	simulation	NOUN
admet-923	25	25	ethics	ethic	NOUN
admet-923	25	26	)	)	PUNCT
admet-923	25	27	.	.	PUNCT
admet-923	26	1	this	this	DET
admet-923	26	2	policy	policy	NOUN
admet-923	26	3	is	be	AUX
admet-923	26	4	introduced	introduce	VERB
admet-923	26	5	to	to	PART
admet-923	26	6	enhance	enhance	VERB
admet-923	26	7	the	the	DET
admet-923	26	8	science	science	NOUN
admet-923	26	9	of	of	ADP
admet-923	26	10	pbpk	pbpk	NOUN
admet-923	26	11	modelling	modelling	NOUN
admet-923	26	12	.	.	PUNCT
admet-923	27	1	in	in	ADP
admet-923	27	2	this	this	DET
admet-923	27	3	article	article	NOUN
admet-923	27	4	,	,	PUNCT
admet-923	27	5	the	the	DET
admet-923	27	6	background	background	NOUN
admet-923	27	7	of	of	ADP
admet-923	27	8	this	this	DET
admet-923	27	9	policy	policy	NOUN
admet-923	27	10	is	be	AUX
admet-923	27	11	explained	explain	VERB
admet-923	27	12	.	.	PUNCT
admet-923	28	1	this	this	DET
admet-923	28	2	article	article	NOUN
admet-923	28	3	consists	consist	VERB
admet-923	28	4	of	of	ADP
admet-923	28	5	three	three	NUM
admet-923	28	6	parts	part	NOUN
admet-923	28	7	:	:	PUNCT
admet-923	28	8	part	part	NOUN
admet-923	28	9	1	1	NUM
admet-923	28	10	:	:	PUNCT
admet-923	28	11	requirements	requirement	NOUN
admet-923	28	12	for	for	ADP
admet-923	28	13	scientific	scientific	ADJ
admet-923	28	14	writing	writing	NOUN
admet-923	28	15	of	of	ADP
admet-923	28	16	pbpk	pbpk	NOUN
admet-923	28	17	modelling	modelling	NOUN
admet-923	28	18	,	,	PUNCT
admet-923	28	19	part	part	NOUN
admet-923	28	20	2	2	NUM
admet-923	28	21	:	:	PUNCT
admet-923	28	22	scientific	scientific	ADJ
admet-923	28	23	literacy	literacy	NOUN
admet-923	28	24	for	for	ADP
admet-923	28	25	pbpk	pbpk	NOUN
admet-923	28	26	modelling	modelling	NOUN
admet-923	28	27	,	,	PUNCT
admet-923	28	28	part	part	NOUN
admet-923	28	29	3	3	NUM
admet-923	28	30	:	:	PUNCT
admet-923	28	31	middle	middle	ADJ
admet-923	28	32	-	-	PUNCT
admet-923	28	33	out	out	ADP
admet-923	28	34	approach	approach	NOUN
admet-923	28	35	(	(	PUNCT
admet-923	28	36	parameter	parameter	NOUN
admet-923	28	37	back	back	NOUN
admet-923	28	38	-	-	PUNCT
admet-923	28	39	calculation	calculation	NOUN
admet-923	28	40	from	from	ADP
admet-923	28	41	clinical	clinical	ADJ
admet-923	28	42	pk	pk	NOUN
admet-923	28	43	data	datum	NOUN
admet-923	28	44	)	)	PUNCT
admet-923	28	45	.	.	PUNCT
admet-923	29	1	the	the	DET
admet-923	29	2	topics	topic	NOUN
admet-923	29	3	discussed	discuss	VERB
admet-923	29	4	in	in	ADP
admet-923	29	5	this	this	DET
admet-923	29	6	article	article	NOUN
admet-923	29	7	have	have	AUX
admet-923	29	8	been	be	AUX
admet-923	29	9	repeatedly	repeatedly	ADV
admet-923	29	10	raised	raise	VERB
admet-923	29	11	before	before	ADV
admet-923	29	12	.	.	PUNCT
admet-923	30	1	transparency	transparency	NOUN
admet-923	30	2	and	and	CCONJ
admet-923	30	3	reproducibility	reproducibility	NOUN
admet-923	30	4	(	(	PUNCT
admet-923	30	5	calculation	calculation	NOUN
admet-923	30	6	traceability	traceability	NOUN
admet-923	30	7	)	)	PUNCT
admet-923	30	8	are	be	AUX
admet-923	30	9	critically	critically	ADV
admet-923	30	10	important	important	ADJ
admet-923	30	11	for	for	ADP
admet-923	30	12	scientific	scientific	ADJ
admet-923	30	13	writing	writing	NOUN
admet-923	30	14	(	(	PUNCT
admet-923	30	15	part	part	NOUN
admet-923	30	16	1	1	NUM
admet-923	30	17	)	)	PUNCT
admet-923	31	1	[	[	X
admet-923	31	2	12–14	12–14	NUM
admet-923	31	3	]	]	X
admet-923	31	4	.	.	PUNCT
admet-923	32	1	from	from	ADP
admet-923	32	2	the	the	DET
admet-923	32	3	perspective	perspective	NOUN
admet-923	32	4	of	of	ADP
admet-923	32	5	evidence	evidence	NOUN
admet-923	32	6	-	-	PUNCT
admet-923	32	7	based	base	VERB
admet-923	32	8	medicine	medicine	NOUN
admet-923	32	9	,	,	PUNCT
admet-923	32	10	case	case	NOUN
admet-923	32	11	studies	study	NOUN
admet-923	32	12	are	be	AUX
admet-923	32	13	less	less	ADV
admet-923	32	14	reliable	reliable	ADJ
admet-923	32	15	for	for	ADP
admet-923	32	16	assessing	assess	VERB
admet-923	32	17	the	the	DET
admet-923	32	18	predictive	predictive	ADJ
admet-923	32	19	power	power	NOUN
admet-923	32	20	of	of	ADP
admet-923	32	21	a	a	DET
admet-923	32	22	model	model	NOUN
admet-923	32	23	(	(	PUNCT
admet-923	32	24	part	part	NOUN
admet-923	32	25	2	2	NUM
admet-923	32	26	)	)	PUNCT
admet-923	33	1	[	[	X
admet-923	33	2	15–17	15–17	NUM
admet-923	33	3	]	]	PUNCT
admet-923	33	4	.	.	PUNCT
admet-923	34	1	the	the	DET
admet-923	34	2	issue	issue	NOUN
admet-923	34	3	of	of	ADP
admet-923	34	4	parameter	parameter	NOUN
admet-923	34	5	identifiability	identifiability	NOUN
admet-923	34	6	in	in	ADP
admet-923	34	7	mathematical	mathematical	ADJ
admet-923	34	8	modelling	modelling	NOUN
admet-923	34	9	has	have	AUX
admet-923	34	10	been	be	AUX
admet-923	34	11	repeatedly	repeatedly	ADV
admet-923	34	12	warned	warn	VERB
admet-923	34	13	in	in	ADP
admet-923	34	14	the	the	DET
admet-923	34	15	literature	literature	NOUN
admet-923	34	16	(	(	PUNCT
admet-923	34	17	part	part	NOUN
admet-923	34	18	3	3	NUM
admet-923	34	19	)	)	PUNCT
admet-923	35	1	[	[	X
admet-923	35	2	18–24	18–24	NUM
admet-923	35	3	]	]	PUNCT
admet-923	35	4	.	.	PUNCT
admet-923	36	1	in	in	ADP
admet-923	36	2	this	this	DET
admet-923	36	3	article	article	NOUN
admet-923	36	4	,	,	PUNCT
admet-923	36	5	the	the	DET
admet-923	36	6	above	above	ADJ
admet-923	36	7	points	point	NOUN
admet-923	36	8	will	will	AUX
admet-923	36	9	be	be	AUX
admet-923	36	10	discussed	discuss	VERB
admet-923	36	11	focusing	focus	VERB
admet-923	36	12	on	on	ADP
admet-923	36	13	oa	oa	ADP
admet-923	36	14	pbpk	pbpk	NOUN
admet-923	36	15	modelling	modelling	NOUN
admet-923	36	16	.	.	PUNCT
admet-923	37	1	but	but	CCONJ
admet-923	37	2	this	this	DET
admet-923	37	3	article	article	NOUN
admet-923	37	4	would	would	AUX
admet-923	37	5	also	also	ADV
admet-923	37	6	be	be	AUX
admet-923	37	7	beneficial	beneficial	ADJ
admet-923	37	8	to	to	ADP
admet-923	37	9	the	the	DET
admet-923	37	10	other	other	ADJ
admet-923	37	11	pbpk	pbpk	ADJ
admet-923	37	12	models	model	NOUN
admet-923	37	13	.	.	PUNCT
admet-923	38	1	pbpk	pbpk	NOUN
admet-923	38	2	models	model	NOUN
admet-923	38	3	will	will	AUX
admet-923	38	4	be	be	AUX
admet-923	38	5	a	a	DET
admet-923	38	6	useful	useful	ADJ
admet-923	38	7	tool	tool	NOUN
admet-923	38	8	if	if	SCONJ
admet-923	38	9	used	use	VERB
admet-923	38	10	correctly	correctly	ADV
admet-923	38	11	.	.	PUNCT
admet-923	39	1	this	this	DET
admet-923	39	2	article	article	NOUN
admet-923	39	3	will	will	AUX
admet-923	39	4	hopefully	hopefully	ADV
admet-923	39	5	enhance	enhance	VERB
admet-923	39	6	the	the	DET
admet-923	39	7	science	science	NOUN
admet-923	39	8	of	of	ADP
admet-923	39	9	oa	oa	PROPN
admet-923	39	10	pbpk	pbpk	NOUN
admet-923	39	11	modelling	modelling	NOUN
admet-923	39	12	in	in	ADP
admet-923	39	13	the	the	DET
admet-923	39	14	future	future	NOUN
admet-923	39	15	.	.	PUNCT
admet-923	40	1	part	part	NOUN
admet-923	40	2	1	1	NUM
admet-923	40	3	:	:	PUNCT
admet-923	40	4	requirements	requirement	NOUN
admet-923	40	5	for	for	ADP
admet-923	40	6	scientific	scientific	ADJ
admet-923	40	7	writing	writing	NOUN
admet-923	40	8	of	of	ADP
admet-923	40	9	pbpk	pbpk	NOUN
admet-923	40	10	modelling	model	VERB
admet-923	40	11	the	the	DET
admet-923	40	12	policy	policy	NOUN
admet-923	40	13	on	on	ADP
admet-923	40	14	the	the	DET
admet-923	40	15	scientific	scientific	ADJ
admet-923	40	16	writing	writing	NOUN
admet-923	40	17	of	of	ADP
admet-923	40	18	physiologically	physiologically	ADV
admet-923	40	19	-	-	PUNCT
admet-923	40	20	based	base	VERB
admet-923	40	21	pharmacokinetic	pharmacokinetic	ADJ
admet-923	40	22	modelling	modelling	NOUN
admet-923	40	23	(	(	PUNCT
admet-923	40	24	pbpk	pbpk	NOUN
admet-923	40	25	)	)	PUNCT
admet-923	40	26	articles	article	NOUN
admet-923	40	27	complements	complement	VERB
admet-923	40	28	the	the	DET
admet-923	40	29	current	current	ADJ
admet-923	40	30	journal	journal	NOUN
admet-923	40	31	's	's	PART
admet-923	40	32	author	author	NOUN
admet-923	40	33	guidelines	guideline	NOUN
admet-923	40	34	that	that	PRON
admet-923	40	35	cover	cover	VERB
admet-923	40	36	in	in	ADP
admet-923	40	37	vivo	vivo	NOUN
admet-923	40	38	and	and	CCONJ
admet-923	40	39	in	in	ADP
admet-923	40	40	vitro	vitro	X
admet-923	40	41	methods	method	NOUN
admet-923	40	42	based	base	VERB
admet-923	40	43	on	on	ADP
admet-923	40	44	scientific	scientific	ADJ
admet-923	40	45	literacy	literacy	NOUN
admet-923	40	46	.	.	PUNCT
admet-923	41	1	this	this	DET
admet-923	41	2	guideline	guideline	NOUN
admet-923	41	3	is	be	AUX
admet-923	41	4	also	also	ADV
admet-923	41	5	in	in	ADP
admet-923	41	6	line	line	NOUN
admet-923	41	7	with	with	ADP
admet-923	41	8	regulatory	regulatory	ADJ
admet-923	41	9	guidance	guidance	NOUN
admet-923	41	10	for	for	ADP
admet-923	41	11	industry	industry	NOUN
admet-923	41	12	regarding	regard	VERB
admet-923	41	13	pbpk	pbpk	NOUN
admet-923	41	14	modelling	modelling	NOUN
admet-923	41	15	[	[	X
admet-923	41	16	12–14	12–14	NUM
admet-923	41	17	]	]	X
admet-923	41	18	.	.	PUNCT
admet-923	42	1	in	in	ADP
admet-923	42	2	this	this	DET
admet-923	42	3	article	article	NOUN
admet-923	42	4	,	,	PUNCT
admet-923	42	5	past	past	ADP
admet-923	42	6	articles	article	NOUN
admet-923	42	7	that	that	PRON
admet-923	42	8	do	do	AUX
admet-923	42	9	not	not	PART
admet-923	42	10	comply	comply	VERB
admet-923	42	11	with	with	ADP
admet-923	42	12	this	this	DET
admet-923	42	13	policy	policy	NOUN
admet-923	42	14	are	be	AUX
admet-923	42	15	not	not	PART
admet-923	42	16	quoted	quote	VERB
admet-923	42	17	,	,	PUNCT
admet-923	42	18	because	because	SCONJ
admet-923	42	19	it	it	PRON
admet-923	42	20	would	would	AUX
admet-923	42	21	be	be	AUX
admet-923	42	22	disadvantageous	disadvantageous	ADJ
admet-923	42	23	for	for	ADP
admet-923	42	24	the	the	DET
admet-923	42	25	authors	author	NOUN
admet-923	42	26	.	.	PUNCT
admet-923	43	1	however	however	ADV
admet-923	43	2	,	,	PUNCT
admet-923	43	3	readers	reader	NOUN
admet-923	43	4	will	will	AUX
admet-923	43	5	see	see	VERB
admet-923	43	6	that	that	SCONJ
admet-923	43	7	the	the	DET
admet-923	43	8	majority	majority	NOUN
admet-923	43	9	of	of	ADP
admet-923	43	10	the	the	DET
admet-923	43	11	past	past	ADJ
admet-923	43	12	papers	paper	NOUN
admet-923	43	13	have	have	VERB
admet-923	43	14	some	some	DET
admet-923	43	15	issues	issue	NOUN
admet-923	43	16	raised	raise	VERB
admet-923	43	17	in	in	ADP
admet-923	43	18	this	this	DET
admet-923	43	19	article	article	NOUN
admet-923	43	20	.	.	PUNCT
admet-923	44	1	transparency	transparency	NOUN
admet-923	44	2	and	and	CCONJ
admet-923	44	3	reproducibility	reproducibility	NOUN
admet-923	44	4	are	be	AUX
admet-923	44	5	mandatory	mandatory	ADJ
admet-923	44	6	to	to	PART
admet-923	44	7	ensure	ensure	VERB
admet-923	44	8	the	the	DET
admet-923	44	9	credibility	credibility	NOUN
admet-923	44	10	of	of	ADP
admet-923	44	11	pbpk	pbpk	NOUN
admet-923	44	12	modelling	modelling	NOUN
admet-923	44	13	.	.	PUNCT
admet-923	45	1	as	as	SCONJ
admet-923	45	2	sciences	science	NOUN
admet-923	45	3	and	and	CCONJ
admet-923	45	4	technology	technology	NOUN
admet-923	45	5	progress	progress	NOUN
admet-923	45	6	,	,	PUNCT
admet-923	45	7	model	model	NOUN
admet-923	45	8	equations	equation	NOUN
admet-923	45	9	and	and	CCONJ
admet-923	45	10	physiological	physiological	ADJ
admet-923	45	11	data	datum	NOUN
admet-923	45	12	can	can	AUX
admet-923	45	13	be	be	AUX
admet-923	45	14	updated	update	VERB
admet-923	45	15	in	in	ADP
admet-923	45	16	the	the	DET
admet-923	45	17	future	future	NOUN
admet-923	45	18	(	(	PUNCT
admet-923	45	19	section	section	NOUN
admet-923	45	20	2.1	2.1	NUM
admet-923	45	21	)	)	PUNCT
admet-923	45	22	.	.	PUNCT
admet-923	46	1	therefore	therefore	ADV
admet-923	46	2	,	,	PUNCT
admet-923	46	3	the	the	DET
admet-923	46	4	use	use	NOUN
admet-923	46	5	of	of	ADP
admet-923	46	6	the	the	DET
admet-923	46	7	current	current	ADJ
admet-923	46	8	best	good	ADJ
admet-923	46	9	estimate	estimate	NOUN
admet-923	46	10	parameter	parameter	NOUN
admet-923	46	11	in	in	ADP
admet-923	46	12	pbpk	pbpk	NOUN
admet-923	46	13	modelling	modelling	NOUN
admet-923	46	14	is	be	AUX
admet-923	46	15	appropriate	appropriate	ADJ
admet-923	46	16	.	.	PUNCT
admet-923	47	1	however	however	ADV
admet-923	47	2	,	,	PUNCT
admet-923	47	3	if	if	SCONJ
admet-923	47	4	the	the	DET
admet-923	47	5	physiological	physiological	ADJ
admet-923	47	6	data	datum	NOUN
admet-923	47	7	or	or	CCONJ
admet-923	47	8	model	model	NOUN
admet-923	47	9	equation	equation	NOUN
admet-923	47	10	changes	change	NOUN
admet-923	47	11	in	in	ADP
admet-923	47	12	the	the	DET
admet-923	47	13	future	future	NOUN
admet-923	47	14	,	,	PUNCT
admet-923	47	15	past	past	ADJ
admet-923	47	16	articles	article	NOUN
admet-923	47	17	need	need	VERB
admet-923	47	18	to	to	PART
admet-923	47	19	be	be	AUX
admet-923	47	20	re	re	VERB
admet-923	47	21	-	-	VERB
admet-923	47	22	evaluated	evaluated	ADJ
admet-923	47	23	.	.	PUNCT
admet-923	48	1	for	for	ADP
admet-923	48	2	example	example	NOUN
admet-923	48	3	,	,	PUNCT
admet-923	48	4	a	a	DET
admet-923	48	5	wide	wide	ADJ
admet-923	48	6	variety	variety	NOUN
admet-923	48	7	of	of	ADP
admet-923	48	8	small	small	ADJ
admet-923	48	9	intestinal	intestinal	ADJ
admet-923	48	10	fluid	fluid	NOUN
admet-923	48	11	volume	volume	NOUN
admet-923	48	12	(	(	PUNCT
admet-923	48	13	vsi	vsi	PROPN
admet-923	48	14	)	)	PUNCT
admet-923	48	15	has	have	AUX
admet-923	48	16	been	be	AUX
admet-923	48	17	used	use	VERB
admet-923	48	18	in	in	ADP
admet-923	48	19	oral	oral	ADJ
admet-923	48	20	absorption	absorption	NOUN
admet-923	48	21	(	(	PUNCT
admet-923	48	22	oa	oa	INTJ
admet-923	48	23	)	)	PUNCT
admet-923	48	24	pbpk	pbpk	NOUN
admet-923	48	25	modelling	modelling	NOUN
admet-923	48	26	,	,	PUNCT
admet-923	48	27	ranging	range	VERB
admet-923	48	28	from	from	ADP
admet-923	48	29	less	less	ADJ
admet-923	48	30	than	than	ADP
admet-923	48	31	100	100	NUM
admet-923	48	32	ml	ml	NOUN
admet-923	48	33	to	to	ADP
admet-923	48	34	over	over	ADP
admet-923	48	35	1500	1500	NUM
admet-923	48	36	ml	ml	NOUN
admet-923	48	37	(	(	PUNCT
admet-923	48	38	the	the	DET
admet-923	48	39	former	former	ADJ
admet-923	48	40	is	be	AUX
admet-923	48	41	based	base	VERB
admet-923	48	42	on	on	ADP
admet-923	48	43	the	the	DET
admet-923	48	44	recent	recent	ADJ
admet-923	48	45	mri	mri	NOUN
admet-923	48	46	measurements	measurement	NOUN
admet-923	48	47	)	)	PUNCT
admet-923	49	1	[	[	X
admet-923	49	2	25–29	25–29	NOUN
admet-923	49	3	]	]	PUNCT
admet-923	49	4	.	.	PUNCT
admet-923	50	1	despite	despite	SCONJ
admet-923	50	2	more	more	ADJ
admet-923	50	3	than	than	ADP
admet-923	50	4	a	a	DET
admet-923	50	5	15	15	NUM
admet-923	50	6	-	-	ADJ
admet-923	50	7	fold	fold	ADJ
admet-923	50	8	difference	difference	NOUN
admet-923	50	9	,	,	PUNCT
admet-923	50	10	they	they	PRON
admet-923	50	11	all	all	PRON
admet-923	50	12	claimed	claim	VERB
admet-923	50	13	good	good	ADJ
admet-923	50	14	predictability	predictability	NOUN
admet-923	50	15	(	(	PUNCT
admet-923	50	16	section	section	NOUN
admet-923	50	17	3.3	3.3	NUM
admet-923	50	18	)	)	PUNCT
admet-923	50	19	.	.	PUNCT
admet-923	51	1	this	this	PRON
admet-923	51	2	can	can	AUX
admet-923	51	3	not	not	PART
admet-923	51	4	be	be	AUX
admet-923	51	5	true	true	ADJ
admet-923	51	6	.	.	PUNCT
admet-923	52	1	if	if	SCONJ
admet-923	52	2	all	all	DET
admet-923	52	3	details	detail	NOUN
admet-923	52	4	had	have	AUX
admet-923	52	5	been	be	AUX
admet-923	52	6	reported	report	VERB
admet-923	52	7	,	,	PUNCT
admet-923	52	8	we	we	PRON
admet-923	52	9	can	can	AUX
admet-923	52	10	trace	trace	VERB
admet-923	52	11	the	the	DET
admet-923	52	12	calculation	calculation	NOUN
admet-923	52	13	and	and	CCONJ
admet-923	52	14	retrospectively	retrospectively	ADV
admet-923	52	15	inspect	inspect	VERB
admet-923	52	16	the	the	DET
admet-923	52	17	reason	reason	NOUN
admet-923	52	18	for	for	ADP
admet-923	52	19	this	this	DET
admet-923	52	20	contradiction	contradiction	NOUN
admet-923	52	21	.	.	PUNCT
admet-923	53	1	but	but	CCONJ
admet-923	53	2	if	if	SCONJ
admet-923	53	3	there	there	PRON
admet-923	53	4	was	be	VERB
admet-923	53	5	an	an	DET
admet-923	53	6	undisclosed	undisclosed	ADJ
admet-923	53	7	part	part	NOUN
admet-923	53	8	,	,	PUNCT
admet-923	53	9	it	it	PRON
admet-923	53	10	is	be	AUX
admet-923	53	11	not	not	PART
admet-923	53	12	possible	possible	ADJ
admet-923	53	13	to	to	PART
admet-923	53	14	judge	judge	VERB
admet-923	53	15	whether	whether	SCONJ
admet-923	53	16	the	the	DET
admet-923	53	17	past	past	ADJ
admet-923	53	18	good	good	ADJ
admet-923	53	19	prediction	prediction	NOUN
admet-923	53	20	is	be	AUX
admet-923	53	21	just	just	ADV
admet-923	53	22	a	a	DET
admet-923	53	23	lucky	lucky	ADJ
admet-923	53	24	coincidence	coincidence	NOUN
admet-923	53	25	or	or	CCONJ
admet-923	53	26	due	due	ADP
admet-923	53	27	to	to	ADP
admet-923	53	28	other	other	ADJ
admet-923	53	29	reasons	reason	NOUN
admet-923	53	30	.	.	PUNCT
admet-923	54	1	when	when	SCONJ
admet-923	54	2	such	such	DET
admet-923	54	3	an	an	DET
admet-923	54	4	inconsistency	inconsistency	NOUN
admet-923	54	5	arises	arise	VERB
admet-923	54	6	in	in	ADP
admet-923	54	7	regulatory	regulatory	ADJ
admet-923	54	8	submissions	submission	NOUN
admet-923	54	9	,	,	PUNCT
admet-923	54	10	it	it	PRON
admet-923	54	11	causes	cause	VERB
admet-923	54	12	a	a	DET
admet-923	54	13	more	more	ADV
admet-923	54	14	troubling	troubling	ADJ
admet-923	54	15	situation	situation	NOUN
admet-923	54	16	.	.	PUNCT
admet-923	55	1	to	to	PART
admet-923	55	2	ensure	ensure	VERB
admet-923	55	3	the	the	DET
admet-923	55	4	credibility	credibility	NOUN
admet-923	55	5	of	of	ADP
admet-923	55	6	pbpk	pbpk	NOUN
admet-923	55	7	modelling	modelling	NOUN
admet-923	55	8	,	,	PUNCT
admet-923	55	9	authors	author	NOUN
admet-923	55	10	must	must	AUX
admet-923	55	11	write	write	VERB
admet-923	55	12	the	the	DET
admet-923	55	13	manuscript	manuscript	NOUN
admet-923	55	14	as	as	ADV
admet-923	55	15	transparent	transparent	ADJ
admet-923	55	16	as	as	ADP
admet-923	55	17	possible	possible	ADJ
admet-923	55	18	to	to	PART
admet-923	55	19	enable	enable	VERB
admet-923	55	20	inspection	inspection	NOUN
admet-923	55	21	by	by	ADP
admet-923	55	22	peer	peer	NOUN
admet-923	55	23	-	-	PUNCT
admet-923	55	24	reviewers	reviewer	NOUN
admet-923	55	25	and	and	CCONJ
admet-923	55	26	ensure	ensure	VERB
admet-923	55	27	reproducibility	reproducibility	NOUN
admet-923	55	28	by	by	ADP
admet-923	55	29	independent	independent	ADJ
admet-923	55	30	third	third	ADJ
admet-923	55	31	parties	party	NOUN
admet-923	55	32	.	.	PUNCT
admet-923	56	1	1.1	1.1	NUM
admet-923	56	2	.	.	PUNCT
admet-923	57	1	introduction	introduction	NOUN
admet-923	57	2	section	section	NOUN
admet-923	57	3	the	the	DET
admet-923	57	4	purpose	purpose	NOUN
admet-923	57	5	of	of	ADP
admet-923	57	6	pbpk	pbpk	NOUN
admet-923	57	7	modelling	modelling	NOUN
admet-923	57	8	should	should	AUX
admet-923	57	9	be	be	AUX
admet-923	57	10	explained	explain	VERB
admet-923	57	11	in	in	ADP
admet-923	57	12	the	the	DET
admet-923	57	13	introduction	introduction	NOUN
admet-923	57	14	section	section	NOUN
admet-923	57	15	.	.	PUNCT
admet-923	58	1	the	the	DET
admet-923	58	2	question	question	NOUN
admet-923	58	3	of	of	ADP
admet-923	58	4	interest	interest	NOUN
admet-923	58	5	and	and	CCONJ
admet-923	58	6	the	the	DET
admet-923	58	7	context	context	NOUN
admet-923	58	8	of	of	ADP
admet-923	58	9	use	use	NOUN
admet-923	58	10	(	(	PUNCT
admet-923	58	11	cou	cou	PROPN
admet-923	58	12	)	)	PUNCT
admet-923	58	13	for	for	ADP
admet-923	58	14	pbpk	pbpk	NOUN
admet-923	58	15	modelling	modelling	NOUN
admet-923	58	16	should	should	AUX
admet-923	58	17	be	be	AUX
admet-923	58	18	described	describe	VERB
admet-923	58	19	[	[	X
admet-923	58	20	10	10	NUM
admet-923	58	21	]	]	PUNCT
admet-923	58	22	.	.	PUNCT
admet-923	59	1	there	there	PRON
admet-923	59	2	is	be	VERB
admet-923	59	3	no	no	DET
admet-923	59	4	one	one	NUM
admet-923	59	5	-	-	PUNCT
admet-923	59	6	size	size	NOUN
admet-923	59	7	-	-	PUNCT
admet-923	59	8	fits	fit	VERB
admet-923	59	9	-	-	PUNCT
admet-923	59	10	all	all	DET
admet-923	59	11	model	model	NOUN
admet-923	59	12	(	(	PUNCT
admet-923	59	13	section	section	NOUN
admet-923	59	14	2.8	2.8	NUM
admet-923	59	15	)	)	PUNCT
admet-923	59	16	.	.	PUNCT
admet-923	60	1	a	a	DET
admet-923	60	2	mathematical	mathematical	ADJ
admet-923	60	3	model	model	NOUN
admet-923	60	4	that	that	PRON
admet-923	60	5	suits	suit	VERB
admet-923	60	6	the	the	DET
admet-923	60	7	purpose	purpose	NOUN
admet-923	60	8	should	should	AUX
admet-923	60	9	be	be	AUX
admet-923	60	10	selected	select	VERB
admet-923	60	11	.	.	PUNCT
admet-923	61	1	the	the	DET
admet-923	61	2	reason	reason	NOUN
admet-923	61	3	for	for	ADP
admet-923	61	4	selecting	select	VERB
admet-923	61	5	a	a	DET
admet-923	61	6	pbpk	pbpk	ADJ
admet-923	61	7	model	model	NOUN
admet-923	61	8	should	should	AUX
admet-923	61	9	be	be	AUX
admet-923	61	10	explained	explain	VERB
admet-923	61	11	.	.	PUNCT
admet-923	62	1	https://pub.iapchem.org/ojs/index.php/admet/pbpk	https://pub.iapchem.org/ojs/index.php/admet/pbpk	PROPN
admet-923	62	2	admet	admet	PROPN
admet-923	62	3	&	&	CCONJ
admet-923	62	4	dmpk	dmpk	PROPN
admet-923	62	5	9(2	9(2	NUM
admet-923	62	6	)	)	PUNCT
admet-923	62	7	(	(	PUNCT
admet-923	62	8	2021	2021	NUM
admet-923	62	9	)	)	PUNCT
admet-923	62	10	75	75	NUM
admet-923	62	11	-	-	SYM
admet-923	62	12	109	109	NUM
admet-923	62	13	lost	lose	VERB
admet-923	62	14	in	in	ADP
admet-923	62	15	modelling	modelling	NOUN
admet-923	62	16	and	and	CCONJ
admet-923	62	17	simulation	simulation	NOUN
admet-923	62	18	?	?	PUNCT
admet-923	63	1	doi	doi	NOUN
admet-923	63	2	:	:	PUNCT
admet-923	63	3	https:/doi.org/10.5599	https:/doi.org/10.5599	PROPN
admet-923	63	4	/	/	SYM
admet-923	63	5	admet.923	admet.923	PROPN
admet-923	63	6	77	77	NUM
admet-923	63	7	1.2	1.2	NUM
admet-923	63	8	.	.	PUNCT
admet-923	64	1	method	method	PROPN
admet-923	64	2	section	section	NOUN
admet-923	64	3	based	base	VERB
admet-923	64	4	on	on	ADP
admet-923	64	5	the	the	DET
admet-923	64	6	scientific	scientific	ADJ
admet-923	64	7	ethics	ethic	NOUN
admet-923	64	8	of	of	ADP
admet-923	64	9	transparency	transparency	NOUN
admet-923	64	10	and	and	CCONJ
admet-923	64	11	reproducibility	reproducibility	NOUN
admet-923	64	12	,	,	PUNCT
admet-923	64	13	authors	author	NOUN
admet-923	64	14	are	be	AUX
admet-923	64	15	requested	request	VERB
admet-923	64	16	to	to	PART
admet-923	64	17	disclose	disclose	VERB
admet-923	64	18	the	the	DET
admet-923	64	19	model	model	NOUN
admet-923	64	20	equations	equation	NOUN
admet-923	64	21	,	,	PUNCT
admet-923	64	22	physiological	physiological	ADJ
admet-923	64	23	parameters	parameter	NOUN
admet-923	64	24	,	,	PUNCT
admet-923	64	25	and	and	CCONJ
admet-923	64	26	drug	drug	NOUN
admet-923	64	27	parameters	parameter	NOUN
admet-923	64	28	(	(	PUNCT
admet-923	64	29	section	section	NOUN
admet-923	64	30	2.1	2.1	NUM
admet-923	64	31	)	)	PUNCT
admet-923	64	32	that	that	PRON
admet-923	64	33	are	be	AUX
admet-923	64	34	sufficient	sufficient	ADJ
admet-923	64	35	for	for	ADP
admet-923	64	36	peerreview	peerreview	NOUN
admet-923	64	37	(	(	PUNCT
admet-923	64	38	or	or	CCONJ
admet-923	64	39	appropriate	appropriate	ADJ
admet-923	64	40	references	reference	NOUN
admet-923	64	41	to	to	ADP
admet-923	64	42	them	they	PRON
admet-923	64	43	)	)	PUNCT
admet-923	64	44	.	.	PUNCT
admet-923	65	1	undisclosed	undisclosed	ADJ
admet-923	65	2	parts	part	NOUN
admet-923	65	3	can	can	AUX
admet-923	65	4	not	not	PART
admet-923	65	5	be	be	AUX
admet-923	65	6	peer	peer	NOUN
admet-923	65	7	-	-	PUNCT
admet-923	65	8	reviewed	review	VERB
admet-923	65	9	in	in	ADP
admet-923	65	10	the	the	DET
admet-923	65	11	first	first	ADJ
admet-923	65	12	place	place	NOUN
admet-923	65	13	.	.	PUNCT
admet-923	66	1	in	in	ADP
admet-923	66	2	addition	addition	NOUN
admet-923	66	3	,	,	PUNCT
admet-923	66	4	according	accord	VERB
admet-923	66	5	the	the	DET
admet-923	66	6	rule	rule	NOUN
admet-923	66	7	of	of	ADP
admet-923	66	8	science	science	NOUN
admet-923	66	9	,	,	PUNCT
admet-923	66	10	an	an	DET
admet-923	66	11	experimental	experimental	ADJ
admet-923	66	12	section	section	NOUN
admet-923	66	13	should	should	AUX
admet-923	66	14	be	be	AUX
admet-923	66	15	written	write	VERB
admet-923	66	16	as	as	ADV
admet-923	66	17	detailed	detailed	ADJ
admet-923	66	18	as	as	ADP
admet-923	66	19	possible	possible	ADJ
admet-923	66	20	so	so	SCONJ
admet-923	66	21	that	that	SCONJ
admet-923	66	22	to	to	PART
admet-923	66	23	“	"	PUNCT
admet-923	66	24	enable	enable	VERB
admet-923	66	25	”	"	PUNCT
admet-923	66	26	reproducing	reproduce	VERB
admet-923	66	27	the	the	DET
admet-923	66	28	same	same	ADJ
admet-923	66	29	result	result	NOUN
admet-923	66	30	.	.	PUNCT
admet-923	67	1	this	this	DET
admet-923	67	2	point	point	NOUN
admet-923	67	3	is	be	AUX
admet-923	67	4	critical	critical	ADJ
admet-923	67	5	for	for	ADP
admet-923	67	6	ensuring	ensure	VERB
admet-923	67	7	the	the	DET
admet-923	67	8	credibility	credibility	NOUN
admet-923	67	9	of	of	ADP
admet-923	67	10	science	science	NOUN
admet-923	67	11	.	.	PUNCT
admet-923	68	1	if	if	SCONJ
admet-923	68	2	the	the	DET
admet-923	68	3	word	word	NOUN
admet-923	68	4	"	"	PUNCT
admet-923	68	5	reproducibility	reproducibility	NOUN
admet-923	68	6	"	"	PUNCT
admet-923	68	7	is	be	AUX
admet-923	68	8	interpreted	interpret	VERB
admet-923	68	9	literally	literally	ADV
admet-923	68	10	,	,	PUNCT
admet-923	68	11	even	even	ADV
admet-923	68	12	if	if	SCONJ
admet-923	68	13	the	the	DET
admet-923	68	14	model	model	NOUN
admet-923	68	15	equations	equation	NOUN
admet-923	68	16	and	and	CCONJ
admet-923	68	17	parameters	parameter	NOUN
admet-923	68	18	are	be	AUX
admet-923	68	19	not	not	PART
admet-923	68	20	disclosed	disclose	VERB
admet-923	68	21	(	(	PUNCT
admet-923	68	22	as	as	ADP
admet-923	68	23	in	in	ADP
admet-923	68	24	a	a	DET
admet-923	68	25	black	black	ADJ
admet-923	68	26	box	box	NOUN
admet-923	68	27	model	model	NOUN
admet-923	68	28	)	)	PUNCT
admet-923	68	29	,	,	PUNCT
admet-923	68	30	the	the	DET
admet-923	68	31	results	result	NOUN
admet-923	68	32	can	can	AUX
admet-923	68	33	be	be	AUX
admet-923	68	34	reproduced	reproduce	VERB
admet-923	68	35	by	by	ADP
admet-923	68	36	using	use	VERB
admet-923	68	37	the	the	DET
admet-923	68	38	same	same	ADJ
admet-923	68	39	input	input	NOUN
admet-923	68	40	data	datum	NOUN
admet-923	68	41	and	and	CCONJ
admet-923	68	42	the	the	DET
admet-923	68	43	same	same	ADJ
admet-923	68	44	software	software	NOUN
admet-923	68	45	(	(	PUNCT
admet-923	68	46	same	same	ADJ
admet-923	68	47	version	version	NOUN
admet-923	68	48	)	)	PUNCT
admet-923	68	49	.	.	PUNCT
admet-923	69	1	in	in	ADP
admet-923	69	2	the	the	DET
admet-923	69	3	context	context	NOUN
admet-923	69	4	of	of	ADP
admet-923	69	5	scientific	scientific	ADJ
admet-923	69	6	credibility	credibility	NOUN
admet-923	69	7	,	,	PUNCT
admet-923	69	8	for	for	ADP
admet-923	69	9	the	the	DET
admet-923	69	10	articles	article	NOUN
admet-923	69	11	of	of	ADP
admet-923	69	12	mechanistic	mechanistic	ADJ
admet-923	69	13	models	model	NOUN
admet-923	69	14	(	(	PUNCT
admet-923	69	15	including	include	VERB
admet-923	69	16	pbpk	pbpk	NOUN
admet-923	69	17	models	model	NOUN
admet-923	69	18	(	(	PUNCT
admet-923	69	19	section	section	NOUN
admet-923	69	20	2.1	2.1	NUM
admet-923	69	21	)	)	PUNCT
admet-923	69	22	)	)	PUNCT
admet-923	69	23	,	,	PUNCT
admet-923	69	24	it	it	PRON
admet-923	69	25	should	should	AUX
admet-923	69	26	be	be	AUX
admet-923	69	27	taken	take	VERB
admet-923	69	28	as	as	ADP
admet-923	69	29	calculation	calculation	NOUN
admet-923	69	30	traceability	traceability	NOUN
admet-923	69	31	.	.	PUNCT
admet-923	70	1	a	a	DET
admet-923	70	2	method	method	NOUN
admet-923	70	3	section	section	NOUN
admet-923	70	4	should	should	AUX
admet-923	70	5	be	be	AUX
admet-923	70	6	detailed	detail	VERB
admet-923	70	7	enough	enough	ADV
admet-923	70	8	to	to	PART
admet-923	70	9	enable	enable	VERB
admet-923	70	10	someone	someone	PRON
admet-923	70	11	who	who	PRON
admet-923	70	12	wants	want	VERB
admet-923	70	13	to	to	PART
admet-923	70	14	trace	trace	VERB
admet-923	70	15	the	the	DET
admet-923	70	16	calculation	calculation	NOUN
admet-923	70	17	process	process	NOUN
admet-923	70	18	,	,	PUNCT
admet-923	70	19	at	at	ADP
admet-923	70	20	least	least	ADJ
admet-923	70	21	in	in	ADP
admet-923	70	22	the	the	DET
admet-923	70	23	essential	essential	ADJ
admet-923	70	24	parts	part	NOUN
admet-923	70	25	for	for	ADP
admet-923	70	26	cou	cou	NOUN
admet-923	70	27	.	.	PUNCT
admet-923	71	1	if	if	SCONJ
admet-923	71	2	a	a	DET
admet-923	71	3	part	part	NOUN
admet-923	71	4	of	of	ADP
admet-923	71	5	the	the	DET
admet-923	71	6	model	model	NOUN
admet-923	71	7	is	be	AUX
admet-923	71	8	not	not	PART
admet-923	71	9	disclosed	disclose	VERB
admet-923	71	10	,	,	PUNCT
admet-923	71	11	that	that	DET
admet-923	71	12	part	part	NOUN
admet-923	71	13	becomes	become	VERB
admet-923	71	14	a	a	DET
admet-923	71	15	"	"	PUNCT
admet-923	71	16	black	black	ADJ
admet-923	71	17	box	box	NOUN
admet-923	71	18	”	"	PUNCT
admet-923	71	19	.	.	PUNCT
admet-923	72	1	because	because	SCONJ
admet-923	72	2	a	a	DET
admet-923	72	3	black	black	ADJ
admet-923	72	4	box	box	NOUN
admet-923	72	5	can	can	AUX
admet-923	72	6	mask	mask	VERB
admet-923	72	7	errors	error	NOUN
admet-923	72	8	in	in	ADP
admet-923	72	9	any	any	DET
admet-923	72	10	part	part	NOUN
admet-923	72	11	of	of	ADP
admet-923	72	12	the	the	DET
admet-923	72	13	model	model	NOUN
admet-923	72	14	,	,	PUNCT
admet-923	72	15	the	the	DET
admet-923	72	16	credibility	credibility	NOUN
admet-923	72	17	of	of	ADP
admet-923	72	18	the	the	DET
admet-923	72	19	entire	entire	ADJ
admet-923	72	20	research	research	NOUN
admet-923	72	21	is	be	AUX
admet-923	72	22	damaged	damage	VERB
admet-923	72	23	by	by	ADP
admet-923	72	24	the	the	DET
admet-923	72	25	existence	existence	NOUN
admet-923	72	26	of	of	ADP
admet-923	72	27	only	only	ADV
admet-923	72	28	one	one	NUM
admet-923	72	29	undisclosed	undisclosed	ADJ
admet-923	72	30	part	part	NOUN
admet-923	72	31	.	.	PUNCT
admet-923	73	1	the	the	DET
admet-923	73	2	scientific	scientific	ADJ
admet-923	73	3	validity	validity	NOUN
admet-923	73	4	of	of	ADP
admet-923	73	5	a	a	DET
admet-923	73	6	research	research	NOUN
admet-923	73	7	article	article	NOUN
admet-923	73	8	is	be	AUX
admet-923	73	9	the	the	DET
admet-923	73	10	author	author	NOUN
admet-923	73	11	’s	’s	PART
admet-923	73	12	responsibility	responsibility	NOUN
admet-923	73	13	,	,	PUNCT
admet-923	73	14	even	even	ADV
admet-923	73	15	when	when	SCONJ
admet-923	73	16	using	use	VERB
admet-923	73	17	commercial	commercial	ADJ
admet-923	73	18	software	software	NOUN
admet-923	73	19	.	.	PUNCT
admet-923	74	1	in	in	ADP
admet-923	74	2	papers	paper	NOUN
admet-923	74	3	using	use	VERB
admet-923	74	4	commercial	commercial	ADJ
admet-923	74	5	software	software	NOUN
admet-923	74	6	,	,	PUNCT
admet-923	74	7	the	the	DET
admet-923	74	8	model	model	NOUN
admet-923	74	9	equations	equation	NOUN
admet-923	74	10	and	and	CCONJ
admet-923	74	11	physiological	physiological	ADJ
admet-923	74	12	parameters	parameter	NOUN
admet-923	74	13	are	be	AUX
admet-923	74	14	often	often	ADV
admet-923	74	15	described	describe	VERB
admet-923	74	16	as	as	ADP
admet-923	74	17	"	"	PUNCT
admet-923	74	18	default	default	NOUN
admet-923	74	19	”	"	PUNCT
admet-923	74	20	.	.	PUNCT
admet-923	75	1	the	the	DET
admet-923	75	2	default	default	NOUN
admet-923	75	3	information	information	NOUN
admet-923	75	4	may	may	AUX
admet-923	75	5	have	have	AUX
admet-923	75	6	been	be	AUX
admet-923	75	7	disclosed	disclose	VERB
admet-923	75	8	in	in	ADP
admet-923	75	9	a	a	DET
admet-923	75	10	user	user	NOUN
admet-923	75	11	’s	’s	PART
admet-923	75	12	manual	manual	NOUN
admet-923	75	13	.	.	PUNCT
admet-923	76	1	however	however	ADV
admet-923	76	2	,	,	PUNCT
admet-923	76	3	it	it	PRON
admet-923	76	4	is	be	AUX
admet-923	76	5	not	not	PART
admet-923	76	6	available	available	ADJ
admet-923	76	7	for	for	ADP
admet-923	76	8	peer	peer	NOUN
admet-923	76	9	-	-	PUNCT
admet-923	76	10	reviewers	reviewer	NOUN
admet-923	76	11	and	and	CCONJ
admet-923	76	12	readers	reader	NOUN
admet-923	76	13	.	.	PUNCT
admet-923	77	1	the	the	DET
admet-923	77	2	default	default	NOUN
admet-923	77	3	model	model	NOUN
admet-923	77	4	equations	equation	NOUN
admet-923	77	5	and	and	CCONJ
admet-923	77	6	physiological	physiological	ADJ
admet-923	77	7	parameters	parameter	NOUN
admet-923	77	8	must	must	AUX
admet-923	77	9	also	also	ADV
admet-923	77	10	be	be	AUX
admet-923	77	11	publicly	publicly	ADV
admet-923	77	12	disclosed	disclose	VERB
admet-923	77	13	.	.	PUNCT
admet-923	78	1	in	in	ADP
admet-923	78	2	nearly	nearly	ADV
admet-923	78	3	all	all	PRON
admet-923	78	4	case	case	NOUN
admet-923	78	5	study	study	NOUN
admet-923	78	6	reports	report	NOUN
admet-923	78	7	of	of	ADP
admet-923	78	8	oa	oa	ADP
admet-923	78	9	pbpk	pbpk	PROPN
admet-923	78	10	modelling	modelling	NOUN
admet-923	78	11	,	,	PUNCT
admet-923	78	12	case	case	NOUN
admet-923	78	13	-	-	PUNCT
admet-923	78	14	by	by	ADP
admet-923	78	15	-	-	PUNCT
admet-923	78	16	case	case	NOUN
admet-923	78	17	parameter	parameter	NOUN
admet-923	78	18	optimization	optimization	NOUN
admet-923	78	19	(	(	PUNCT
admet-923	78	20	backcalculation	backcalculation	NOUN
admet-923	78	21	)	)	PUNCT
admet-923	78	22	has	have	AUX
admet-923	78	23	been	be	AUX
admet-923	78	24	committed	commit	VERB
admet-923	78	25	to	to	PART
admet-923	78	26	fit	fit	VERB
admet-923	78	27	the	the	DET
admet-923	78	28	simulated	simulated	ADJ
admet-923	78	29	plasma	plasma	NOUN
admet-923	78	30	concentration	concentration	NOUN
admet-923	78	31	(	(	PUNCT
admet-923	78	32	cp	cp	NOUN
admet-923	78	33	)	)	PUNCT
admet-923	78	34	time	time	NOUN
admet-923	78	35	curve	curve	NOUN
admet-923	78	36	to	to	ADP
admet-923	78	37	the	the	DET
admet-923	78	38	clinical	clinical	ADJ
admet-923	78	39	observation	observation	NOUN
admet-923	78	40	on	on	ADP
admet-923	78	41	a	a	DET
admet-923	78	42	drug	drug	NOUN
admet-923	78	43	-	-	PUNCT
admet-923	78	44	by	by	ADP
admet-923	78	45	-	-	PUNCT
admet-923	78	46	drug	drug	NOUN
admet-923	78	47	basis	basis	NOUN
admet-923	78	48	(	(	PUNCT
admet-923	78	49	called	call	VERB
admet-923	78	50	“	"	PUNCT
admet-923	78	51	local	local	ADJ
admet-923	78	52	middle	middle	ADJ
admet-923	78	53	-	-	PUNCT
admet-923	78	54	out	out	ADP
admet-923	78	55	approach	approach	NOUN
admet-923	78	56	”	"	PUNCT
admet-923	78	57	,	,	PUNCT
admet-923	78	58	see	see	VERB
admet-923	78	59	part	part	NOUN
admet-923	78	60	3	3	NUM
admet-923	78	61	)	)	PUNCT
admet-923	78	62	.	.	PUNCT
admet-923	79	1	any	any	DET
admet-923	79	2	parameter	parameter	NOUN
admet-923	79	3	backcalculation	backcalculation	NOUN
admet-923	79	4	from	from	ADP
admet-923	79	5	clinical	clinical	ADJ
admet-923	79	6	pk	pk	NOUN
admet-923	79	7	data	datum	NOUN
admet-923	79	8	must	must	AUX
admet-923	79	9	be	be	AUX
admet-923	79	10	explicitly	explicitly	ADV
admet-923	79	11	stated	state	VERB
admet-923	79	12	in	in	ADP
admet-923	79	13	the	the	DET
admet-923	79	14	method	method	NOUN
admet-923	79	15	section	section	NOUN
admet-923	79	16	.	.	PUNCT
admet-923	80	1	case	case	NOUN
admet-923	80	2	-	-	PUNCT
admet-923	80	3	by	by	ADP
admet-923	80	4	-	-	PUNCT
admet-923	80	5	case	case	NOUN
admet-923	80	6	parameter	parameter	NOUN
admet-923	80	7	back	back	NOUN
admet-923	80	8	-	-	PUNCT
admet-923	80	9	calculation	calculation	NOUN
admet-923	80	10	could	could	AUX
admet-923	80	11	have	have	AUX
admet-923	80	12	been	be	AUX
admet-923	80	13	unconsciously	unconsciously	ADV
admet-923	80	14	committed	commit	VERB
admet-923	80	15	.	.	PUNCT
admet-923	81	1	for	for	ADP
admet-923	81	2	example	example	NOUN
admet-923	81	3	,	,	PUNCT
admet-923	81	4	ad	ad	X
admet-923	81	5	hoc	hoc	X
admet-923	81	6	selection	selection	NOUN
admet-923	81	7	of	of	ADP
admet-923	81	8	estimated	estimate	VERB
admet-923	81	9	permeability	permeability	NOUN
admet-923	81	10	values	value	NOUN
admet-923	81	11	from	from	ADP
admet-923	81	12	in	in	ADP
admet-923	81	13	silico	silico	NOUN
admet-923	81	14	,	,	PUNCT
admet-923	81	15	in	in	ADP
admet-923	81	16	vitro	vitro	NOUN
admet-923	81	17	,	,	PUNCT
admet-923	81	18	or	or	CCONJ
admet-923	81	19	in	in	ADP
admet-923	81	20	situ	situ	ADJ
admet-923	81	21	data	data	NOUN
admet-923	81	22	is	be	AUX
admet-923	81	23	a	a	DET
admet-923	81	24	kind	kind	NOUN
admet-923	81	25	of	of	ADP
admet-923	81	26	parameter	parameter	NOUN
admet-923	81	27	back	back	NOUN
admet-923	81	28	-	-	PUNCT
admet-923	81	29	calculation	calculation	NOUN
admet-923	81	30	.	.	PUNCT
admet-923	82	1	various	various	ADJ
admet-923	82	2	terms	term	NOUN
admet-923	82	3	implying	imply	VERB
admet-923	82	4	a	a	DET
admet-923	82	5	subtle	subtle	ADJ
admet-923	82	6	adjustment	adjustment	NOUN
admet-923	82	7	such	such	ADJ
admet-923	82	8	as	as	ADP
admet-923	82	9	“	"	PUNCT
admet-923	82	10	optimize	optimize	NOUN
admet-923	82	11	”	"	PUNCT
admet-923	82	12	,	,	PUNCT
admet-923	82	13	“	"	PUNCT
admet-923	82	14	fit	fit	NOUN
admet-923	82	15	”	"	PUNCT
admet-923	82	16	,	,	PUNCT
admet-923	82	17	“	"	PUNCT
admet-923	82	18	adjust	adjust	VERB
admet-923	82	19	”	"	PUNCT
admet-923	82	20	,	,	PUNCT
admet-923	82	21	“	"	PUNCT
admet-923	82	22	recover	recover	NOUN
admet-923	82	23	”	"	PUNCT
admet-923	82	24	,	,	PUNCT
admet-923	82	25	“	"	PUNCT
admet-923	82	26	refine	refine	ADJ
admet-923	82	27	”	"	PUNCT
admet-923	82	28	,	,	PUNCT
admet-923	82	29	and	and	CCONJ
admet-923	82	30	“	"	PUNCT
admet-923	82	31	software	software	NOUN
admet-923	82	32	estimated	estimate	VERB
admet-923	82	33	”	"	PUNCT
admet-923	82	34	,	,	PUNCT
admet-923	82	35	have	have	AUX
admet-923	82	36	been	be	AUX
admet-923	82	37	used	use	VERB
admet-923	82	38	to	to	PART
admet-923	82	39	refer	refer	VERB
admet-923	82	40	to	to	PART
admet-923	82	41	parameter	parameter	VERB
admet-923	82	42	back	back	ADJ
admet-923	82	43	-	-	PUNCT
admet-923	82	44	calculation	calculation	NOUN
admet-923	82	45	.	.	PUNCT
admet-923	83	1	however	however	ADV
admet-923	83	2	,	,	PUNCT
admet-923	83	3	the	the	DET
admet-923	83	4	difference	difference	NOUN
admet-923	83	5	from	from	ADP
admet-923	83	6	the	the	DET
admet-923	83	7	initial	initial	ADJ
admet-923	83	8	value	value	NOUN
admet-923	83	9	often	often	ADV
admet-923	83	10	exceeds	exceed	VERB
admet-923	83	11	two	two	NUM
admet-923	83	12	-	-	NOUN
admet-923	83	13	fold	fold	NOUN
admet-923	83	14	due	due	ADP
admet-923	83	15	to	to	ADP
admet-923	83	16	the	the	DET
admet-923	83	17	large	large	ADJ
admet-923	83	18	errors	error	NOUN
admet-923	83	19	in	in	ADP
admet-923	83	20	in	in	ADP
admet-923	83	21	vitro	vitro	X
admet-923	83	22	–	–	PUNCT
admet-923	83	23	in	in	ADP
admet-923	83	24	vivo	vivo	ADJ
admet-923	83	25	extrapolation	extrapolation	NOUN
admet-923	83	26	(	(	PUNCT
admet-923	83	27	ivive	ivive	ADJ
admet-923	83	28	)	)	PUNCT
admet-923	83	29	and/or	and/or	CCONJ
admet-923	83	30	in	in	ADP
admet-923	83	31	silico	silico	NOUN
admet-923	83	32	prediction	prediction	NOUN
admet-923	84	1	[	[	X
admet-923	84	2	30,31	30,31	NUM
admet-923	84	3	]	]	X
admet-923	84	4	(	(	PUNCT
admet-923	84	5	section	section	NOUN
admet-923	84	6	3.10	3.10	NUM
admet-923	84	7	)	)	PUNCT
admet-923	84	8	.	.	PUNCT
admet-923	85	1	when	when	SCONJ
admet-923	85	2	a	a	DET
admet-923	85	3	parameter	parameter	NOUN
admet-923	85	4	is	be	AUX
admet-923	85	5	calculated	calculate	VERB
admet-923	85	6	from	from	ADP
admet-923	85	7	a	a	DET
admet-923	85	8	chemical	chemical	NOUN
admet-923	85	9	structure	structure	NOUN
admet-923	85	10	by	by	ADP
admet-923	85	11	an	an	PRON
admet-923	85	12	in	in	ADP
admet-923	85	13	silico	silico	NOUN
admet-923	85	14	model	model	NOUN
admet-923	85	15	,	,	PUNCT
admet-923	85	16	the	the	DET
admet-923	85	17	prediction	prediction	NOUN
admet-923	85	18	accuracy	accuracy	NOUN
admet-923	85	19	of	of	ADP
admet-923	85	20	the	the	DET
admet-923	85	21	in	in	ADP
admet-923	85	22	silico	silico	NOUN
admet-923	85	23	model	model	NOUN
admet-923	85	24	should	should	AUX
admet-923	85	25	be	be	AUX
admet-923	85	26	shown	show	VERB
admet-923	85	27	(	(	PUNCT
admet-923	85	28	or	or	CCONJ
admet-923	85	29	referenced	reference	VERB
admet-923	85	30	)	)	PUNCT
admet-923	85	31	(	(	PUNCT
admet-923	85	32	section	section	NOUN
admet-923	85	33	3.8	3.8	NUM
admet-923	85	34	(	(	PUNCT
admet-923	85	35	iv	iv	NOUN
admet-923	85	36	)	)	PUNCT
admet-923	85	37	)	)	PUNCT
admet-923	85	38	.	.	PUNCT
admet-923	86	1	1.3	1.3	NUM
admet-923	86	2	.	.	PUNCT
admet-923	86	3	results	result	NOUN
admet-923	86	4	section	section	NOUN
admet-923	86	5	when	when	SCONJ
admet-923	86	6	case	case	NOUN
admet-923	86	7	-	-	PUNCT
admet-923	86	8	by	by	ADP
admet-923	86	9	-	-	PUNCT
admet-923	86	10	case	case	NOUN
admet-923	86	11	parameter	parameter	NOUN
admet-923	86	12	back	back	NOUN
admet-923	86	13	-	-	PUNCT
admet-923	86	14	calculation	calculation	NOUN
admet-923	86	15	was	be	AUX
admet-923	86	16	committed	commit	VERB
admet-923	86	17	,	,	PUNCT
admet-923	86	18	the	the	DET
admet-923	86	19	initial	initial	ADJ
admet-923	86	20	input	input	NOUN
admet-923	86	21	parameters	parameter	NOUN
admet-923	86	22	and	and	CCONJ
admet-923	86	23	the	the	DET
admet-923	86	24	simulation	simulation	NOUN
admet-923	86	25	results	result	VERB
admet-923	86	26	before	before	SCONJ
admet-923	86	27	parameter	parameter	NOUN
admet-923	86	28	back	back	NOUN
admet-923	86	29	-	-	PUNCT
admet-923	86	30	calculation	calculation	NOUN
admet-923	86	31	must	must	AUX
admet-923	86	32	be	be	AUX
admet-923	86	33	reported	report	VERB
admet-923	86	34	in	in	ADP
admet-923	86	35	the	the	DET
admet-923	86	36	result	result	NOUN
admet-923	86	37	section	section	NOUN
admet-923	86	38	(	(	PUNCT
admet-923	86	39	figure	figure	NOUN
admet-923	86	40	1	1	NUM
admet-923	86	41	)	)	PUNCT
admet-923	86	42	.	.	PUNCT
admet-923	87	1	unfortunately	unfortunately	ADV
admet-923	87	2	,	,	PUNCT
admet-923	87	3	the	the	DET
admet-923	87	4	failed	fail	VERB
admet-923	87	5	prediction	prediction	NOUN
admet-923	87	6	is	be	AUX
admet-923	87	7	often	often	ADV
admet-923	87	8	undisclosed	undisclose	VERB
admet-923	87	9	in	in	ADP
admet-923	87	10	case	case	NOUN
admet-923	87	11	study	study	NOUN
admet-923	87	12	reports	report	NOUN
admet-923	87	13	.	.	PUNCT
admet-923	88	1	however	however	ADV
admet-923	88	2	,	,	PUNCT
admet-923	88	3	this	this	DET
admet-923	88	4	information	information	NOUN
admet-923	88	5	is	be	AUX
admet-923	88	6	important	important	ADJ
admet-923	88	7	for	for	ADP
admet-923	88	8	evaluating	evaluate	VERB
admet-923	88	9	the	the	DET
admet-923	88	10	creditability	creditability	NOUN
admet-923	88	11	of	of	ADP
admet-923	88	12	a	a	DET
admet-923	88	13	back	back	ADV
admet-923	88	14	-	-	PUNCT
admet-923	88	15	calculated	calculate	VERB
admet-923	88	16	parameter	parameter	NOUN
admet-923	88	17	.	.	PUNCT
admet-923	89	1	for	for	ADP
admet-923	89	2	the	the	DET
admet-923	89	3	advancement	advancement	NOUN
admet-923	89	4	of	of	ADP
admet-923	89	5	science	science	NOUN
admet-923	89	6	,	,	PUNCT
admet-923	89	7	failed	fail	VERB
admet-923	89	8	predictions	prediction	NOUN
admet-923	89	9	are	be	AUX
admet-923	89	10	just	just	ADV
admet-923	89	11	as	as	ADP
admet-923	89	12	(	(	PUNCT
admet-923	89	13	or	or	CCONJ
admet-923	89	14	even	even	ADV
admet-923	89	15	more	more	ADJ
admet-923	89	16	)	)	PUNCT
admet-923	89	17	important	important	ADJ
admet-923	89	18	than	than	ADP
admet-923	89	19	successful	successful	ADJ
admet-923	89	20	cases	case	NOUN
admet-923	89	21	(	(	PUNCT
admet-923	89	22	section	section	NOUN
admet-923	89	23	3.4	3.4	NUM
admet-923	89	24	)	)	PUNCT
admet-923	89	25	.	.	PUNCT
admet-923	90	1	after	after	ADP
admet-923	90	2	case	case	NOUN
admet-923	90	3	-	-	PUNCT
admet-923	90	4	by	by	ADP
admet-923	90	5	-	-	PUNCT
admet-923	90	6	case	case	NOUN
admet-923	90	7	parameter	parameter	NOUN
admet-923	90	8	back	back	NOUN
admet-923	90	9	-	-	PUNCT
admet-923	90	10	calculation	calculation	NOUN
admet-923	90	11	,	,	PUNCT
admet-923	90	12	the	the	DET
admet-923	90	13	fitted	fit	VERB
admet-923	90	14	curve	curve	NOUN
admet-923	90	15	must	must	AUX
admet-923	90	16	be	be	AUX
admet-923	90	17	labeled	label	VERB
admet-923	90	18	as	as	ADP
admet-923	90	19	“	"	PUNCT
admet-923	90	20	fitted	fit	VERB
admet-923	90	21	”	"	PUNCT
admet-923	90	22	(	(	PUNCT
admet-923	90	23	not	not	PART
admet-923	90	24	“	"	PUNCT
admet-923	90	25	predicted	predict	VERB
admet-923	90	26	”	"	PUNCT
admet-923	90	27	)	)	PUNCT
admet-923	90	28	for	for	ADP
admet-923	90	29	the	the	DET
admet-923	90	30	same	same	ADJ
admet-923	90	31	clinical	clinical	ADJ
admet-923	90	32	pk	pk	NOUN
admet-923	90	33	data	datum	NOUN
admet-923	90	34	used	use	VERB
admet-923	90	35	for	for	ADP
admet-923	90	36	parameter	parameter	NOUN
admet-923	90	37	fitting	fitting	ADJ
admet-923	90	38	.	.	PUNCT
admet-923	91	1	the	the	DET
admet-923	91	2	fitted	fit	VERB
admet-923	91	3	cp	cp	PROPN
admet-923	91	4	time	time	NOUN
admet-923	91	5	curve	curve	NOUN
admet-923	91	6	is	be	AUX
admet-923	91	7	not	not	PART
admet-923	91	8	a	a	DET
admet-923	91	9	predicted	predict	VERB
admet-923	91	10	curve	curve	NOUN
admet-923	91	11	,	,	PUNCT
admet-923	91	12	because	because	SCONJ
admet-923	91	13	the	the	DET
admet-923	91	14	observed	observed	ADJ
admet-923	91	15	cp	cp	NOUN
admet-923	91	16	time	time	NOUN
admet-923	91	17	profile	profile	NOUN
admet-923	91	18	has	have	AUX
admet-923	91	19	been	be	AUX
admet-923	91	20	used	use	VERB
admet-923	91	21	to	to	PART
admet-923	91	22	back	back	VERB
admet-923	91	23	-	-	PUNCT
admet-923	91	24	calculate	calculate	VERB
admet-923	91	25	the	the	DET
admet-923	91	26	parameter	parameter	NOUN
admet-923	91	27	(	(	PUNCT
admet-923	91	28	self	self	NOUN
admet-923	91	29	-	-	PUNCT
admet-923	91	30	referencing	referencing	NOUN
admet-923	91	31	)	)	PUNCT
admet-923	91	32	(	(	PUNCT
admet-923	91	33	section	section	NOUN
admet-923	91	34	3.11	3.11	NUM
admet-923	91	35	)	)	PUNCT
admet-923	91	36	.	.	PUNCT
admet-923	92	1	in	in	ADP
admet-923	92	2	oral	oral	ADJ
admet-923	92	3	absorption	absorption	NOUN
admet-923	92	4	(	(	PUNCT
admet-923	92	5	oa	oa	INTJ
admet-923	92	6	)	)	PUNCT
admet-923	92	7	pbpk	pbpk	NOUN
admet-923	92	8	modelling	modelling	NOUN
admet-923	92	9	,	,	PUNCT
admet-923	92	10	the	the	DET
admet-923	92	11	fraction	fraction	NOUN
admet-923	92	12	of	of	ADP
admet-923	92	13	a	a	DET
admet-923	92	14	dose	dose	NOUN
admet-923	92	15	absorbed	absorb	VERB
admet-923	92	16	(	(	PUNCT
admet-923	92	17	fa	fa	NOUN
admet-923	92	18	)	)	PUNCT
admet-923	92	19	is	be	AUX
admet-923	92	20	one	one	NUM
admet-923	92	21	of	of	ADP
admet-923	92	22	the	the	DET
admet-923	92	23	most	most	ADV
admet-923	92	24	https://doi.org/10.5599/admet.923	https://doi.org/10.5599/admet.923	NUM
admet-923	92	25	kiyohiko	kiyohiko	NOUN
admet-923	92	26	sugano	sugano	PROPN
admet-923	92	27	admet	admet	PROPN
admet-923	92	28	&	&	CCONJ
admet-923	92	29	dmpk	dmpk	PROPN
admet-923	92	30	9(2	9(2	NUM
admet-923	92	31	)	)	PUNCT
admet-923	92	32	(	(	PUNCT
admet-923	92	33	2021	2021	NUM
admet-923	92	34	)	)	PUNCT
admet-923	92	35	75	75	NUM
admet-923	92	36	-	-	SYM
admet-923	92	37	109	109	NUM
admet-923	92	38	78	78	NUM
admet-923	92	39	important	important	ADJ
admet-923	92	40	outputs	output	NOUN
admet-923	92	41	for	for	ADP
admet-923	92	42	understanding	understand	VERB
admet-923	92	43	the	the	DET
admet-923	92	44	oral	oral	ADJ
admet-923	92	45	absorption	absorption	NOUN
admet-923	92	46	of	of	ADP
admet-923	92	47	a	a	DET
admet-923	92	48	drug	drug	NOUN
admet-923	92	49	.	.	PUNCT
admet-923	93	1	although	although	SCONJ
admet-923	93	2	clinical	clinical	ADJ
admet-923	93	3	fa	fa	PROPN
admet-923	93	4	data	datum	NOUN
admet-923	93	5	(	(	PUNCT
admet-923	93	6	or	or	CCONJ
admet-923	93	7	its	its	PRON
admet-923	93	8	surrogates	surrogate	NOUN
admet-923	93	9	(	(	PUNCT
admet-923	93	10	section	section	NOUN
admet-923	93	11	2.6	2.6	NUM
admet-923	93	12	)	)	PUNCT
admet-923	93	13	)	)	PUNCT
admet-923	93	14	is	be	AUX
admet-923	93	15	not	not	PART
admet-923	93	16	always	always	ADV
admet-923	93	17	available	available	ADJ
admet-923	93	18	for	for	ADP
admet-923	93	19	model	model	NOUN
admet-923	93	20	validation	validation	NOUN
admet-923	93	21	,	,	PUNCT
admet-923	93	22	simulated	simulate	VERB
admet-923	93	23	fa	fa	PROPN
admet-923	93	24	data	datum	NOUN
admet-923	93	25	is	be	AUX
admet-923	93	26	important	important	ADJ
admet-923	93	27	for	for	ADP
admet-923	93	28	interpreting	interpret	VERB
admet-923	93	29	the	the	DET
admet-923	93	30	simulation	simulation	NOUN
admet-923	93	31	results	result	NOUN
admet-923	93	32	regarding	regard	VERB
admet-923	93	33	the	the	DET
admet-923	93	34	oral	oral	ADJ
admet-923	93	35	absorption	absorption	NOUN
admet-923	93	36	of	of	ADP
admet-923	93	37	a	a	DET
admet-923	93	38	drug	drug	NOUN
admet-923	93	39	,	,	PUNCT
admet-923	93	40	at	at	ADP
admet-923	93	41	least	least	ADJ
admet-923	93	42	for	for	ADP
admet-923	93	43	biopharmaceutics	biopharmaceutics	NOUN
admet-923	93	44	and	and	CCONJ
admet-923	93	45	formulation	formulation	NOUN
admet-923	93	46	scientists	scientist	NOUN
admet-923	93	47	(	(	PUNCT
admet-923	93	48	section	section	NOUN
admet-923	93	49	2.2	2.2	NUM
admet-923	93	50	)	)	PUNCT
admet-923	93	51	.	.	PUNCT
admet-923	94	1	therefore	therefore	ADV
admet-923	94	2	,	,	PUNCT
admet-923	94	3	a	a	DET
admet-923	94	4	simulated	simulate	VERB
admet-923	94	5	fa	fa	NOUN
admet-923	94	6	value	value	NOUN
admet-923	94	7	should	should	AUX
admet-923	94	8	be	be	AUX
admet-923	94	9	reported	report	VERB
admet-923	94	10	.	.	PUNCT
admet-923	95	1	the	the	DET
admet-923	95	2	simulated	simulate	VERB
admet-923	95	3	fa	fa	NOUN
admet-923	95	4	value	value	NOUN
admet-923	95	5	(	(	PUNCT
admet-923	95	6	or	or	CCONJ
admet-923	95	7	the	the	DET
admet-923	95	8	fa	fa	NOUN
admet-923	95	9	–	–	PUNCT
admet-923	95	10	time	time	NOUN
admet-923	95	11	profile	profile	NOUN
admet-923	95	12	)	)	PUNCT
admet-923	95	13	is	be	AUX
admet-923	95	14	available	available	ADJ
admet-923	95	15	as	as	ADP
admet-923	95	16	an	an	DET
admet-923	95	17	output	output	NOUN
admet-923	95	18	in	in	ADP
admet-923	95	19	all	all	DET
admet-923	95	20	commercial	commercial	ADJ
admet-923	95	21	oa	oa	ADP
admet-923	95	22	pbpk	pbpk	ADJ
admet-923	95	23	software	software	NOUN
admet-923	95	24	products	product	NOUN
admet-923	95	25	.	.	PUNCT
admet-923	96	1	however	however	ADV
admet-923	96	2	,	,	PUNCT
admet-923	96	3	unfortunately	unfortunately	ADV
admet-923	96	4	,	,	PUNCT
admet-923	96	5	this	this	DET
admet-923	96	6	value	value	NOUN
admet-923	96	7	has	have	AUX
admet-923	96	8	not	not	PART
admet-923	96	9	been	be	AUX
admet-923	96	10	reported	report	VERB
admet-923	96	11	in	in	ADP
admet-923	96	12	many	many	ADJ
admet-923	96	13	reports	report	NOUN
admet-923	96	14	.	.	PUNCT
admet-923	97	1	figure	figure	NOUN
admet-923	97	2	1	1	NUM
admet-923	97	3	.	.	PUNCT
admet-923	97	4	schematic	schematic	ADJ
admet-923	97	5	illustration	illustration	NOUN
admet-923	97	6	of	of	ADP
admet-923	97	7	simulated	simulate	VERB
admet-923	97	8	and	and	CCONJ
admet-923	97	9	observed	observe	VERB
admet-923	97	10	cp	cp	INTJ
admet-923	97	11	–	–	PUNCT
admet-923	97	12	time	time	NOUN
admet-923	97	13	profiles	profile	NOUN
admet-923	97	14	1.4	1.4	NUM
admet-923	97	15	.	.	PUNCT
admet-923	98	1	discussion	discussion	NOUN
admet-923	98	2	section	section	NOUN
admet-923	98	3	when	when	SCONJ
admet-923	98	4	parameter	parameter	PROPN
admet-923	98	5	back	back	NOUN
admet-923	98	6	-	-	PUNCT
admet-923	98	7	calculation	calculation	NOUN
admet-923	98	8	from	from	ADP
admet-923	98	9	clinical	clinical	ADJ
admet-923	98	10	pk	pk	NOUN
admet-923	98	11	data	datum	NOUN
admet-923	98	12	is	be	AUX
admet-923	98	13	committed	commit	VERB
admet-923	98	14	,	,	PUNCT
admet-923	98	15	the	the	DET
admet-923	98	16	following	follow	VERB
admet-923	98	17	points	point	NOUN
admet-923	98	18	should	should	AUX
admet-923	98	19	be	be	AUX
admet-923	98	20	discussed	discuss	VERB
admet-923	98	21	(	(	PUNCT
admet-923	98	22	see	see	VERB
admet-923	98	23	part	part	NOUN
admet-923	98	24	3	3	NUM
admet-923	98	25	for	for	ADP
admet-923	98	26	details	detail	NOUN
admet-923	98	27	)	)	PUNCT
admet-923	99	1	[	[	X
admet-923	99	2	18–24,32–34	18–24,32–34	NUM
admet-923	99	3	]	]	X
admet-923	99	4	:	:	PUNCT
admet-923	99	5	(	(	PUNCT
admet-923	99	6	i	i	NOUN
admet-923	99	7	)	)	PUNCT
admet-923	99	8	the	the	DET
admet-923	99	9	reason	reason	NOUN
admet-923	99	10	for	for	ADP
admet-923	99	11	the	the	DET
admet-923	99	12	mismatch	mismatch	NOUN
admet-923	99	13	of	of	ADP
admet-923	99	14	the	the	DET
admet-923	99	15	initial	initial	ADJ
admet-923	99	16	“	"	PUNCT
admet-923	99	17	bottom	bottom	ADJ
admet-923	99	18	-	-	PUNCT
admet-923	99	19	up	up	ADP
admet-923	99	20	”	"	PUNCT
admet-923	99	21	prediction	prediction	NOUN
admet-923	99	22	and	and	CCONJ
admet-923	99	23	clinical	clinical	ADJ
admet-923	99	24	pk	pk	NOUN
admet-923	99	25	data	datum	NOUN
admet-923	99	26	,	,	PUNCT
admet-923	99	27	(	(	PUNCT
admet-923	99	28	ii	ii	NOUN
admet-923	99	29	)	)	PUNCT
admet-923	99	30	the	the	DET
admet-923	99	31	reason	reason	NOUN
admet-923	99	32	for	for	ADP
admet-923	99	33	selecting	select	VERB
admet-923	99	34	a	a	DET
admet-923	99	35	parameter	parameter	NOUN
admet-923	99	36	as	as	ADP
admet-923	99	37	the	the	DET
admet-923	99	38	subject	subject	NOUN
admet-923	99	39	of	of	ADP
admet-923	99	40	back	back	NOUN
admet-923	99	41	-	-	PUNCT
admet-923	99	42	calculation	calculation	NOUN
admet-923	99	43	(	(	PUNCT
admet-923	99	44	sections	section	NOUN
admet-923	99	45	3.5	3.5	NUM
admet-923	99	46	to	to	ADP
admet-923	99	47	3.7	3.7	NUM
admet-923	99	48	)	)	PUNCT
admet-923	99	49	,	,	PUNCT
admet-923	99	50	(	(	PUNCT
admet-923	99	51	iii	iii	X
admet-923	99	52	)	)	PUNCT
admet-923	99	53	parameter	parameter	NOUN
admet-923	99	54	identifiability	identifiability	NOUN
admet-923	99	55	(	(	PUNCT
admet-923	99	56	section	section	NOUN
admet-923	99	57	3.2	3.2	NUM
admet-923	99	58	)	)	PUNCT
admet-923	99	59	,	,	PUNCT
admet-923	99	60	(	(	PUNCT
admet-923	99	61	iv	iv	X
admet-923	99	62	)	)	PUNCT
admet-923	99	63	the	the	DET
admet-923	99	64	accuracy	accuracy	NOUN
admet-923	99	65	of	of	ADP
admet-923	99	66	the	the	DET
admet-923	99	67	other	other	ADJ
admet-923	99	68	parameters	parameter	NOUN
admet-923	99	69	than	than	ADP
admet-923	99	70	the	the	DET
admet-923	99	71	subject	subject	NOUN
admet-923	99	72	of	of	ADP
admet-923	99	73	parameter	parameter	NOUN
admet-923	99	74	back	back	NOUN
admet-923	99	75	-	-	PUNCT
admet-923	99	76	calculation	calculation	NOUN
admet-923	99	77	(	(	PUNCT
admet-923	99	78	section	section	NOUN
admet-923	99	79	3.8	3.8	NUM
admet-923	99	80	)	)	PUNCT
admet-923	99	81	,	,	PUNCT
admet-923	99	82	(	(	PUNCT
admet-923	99	83	v	v	X
admet-923	99	84	)	)	PUNCT
admet-923	99	85	the	the	DET
admet-923	99	86	plausibility	plausibility	NOUN
admet-923	99	87	of	of	ADP
admet-923	99	88	back	back	ADV
admet-923	99	89	-	-	PUNCT
admet-923	99	90	calculated	calculate	VERB
admet-923	99	91	parameter	parameter	NOUN
admet-923	99	92	considering	consider	VERB
admet-923	99	93	physicochemical	physicochemical	ADJ
admet-923	99	94	properties	property	NOUN
admet-923	99	95	,	,	PUNCT
admet-923	99	96	in	in	ADP
admet-923	99	97	vitro	vitro	X
admet-923	99	98	data	datum	NOUN
admet-923	99	99	,	,	PUNCT
admet-923	99	100	and	and	CCONJ
admet-923	99	101	in	in	ADP
admet-923	99	102	vivo	vivo	ADJ
admet-923	99	103	physiology	physiology	NOUN
admet-923	99	104	(	(	PUNCT
admet-923	99	105	section	section	NOUN
admet-923	99	106	3.10	3.10	NUM
admet-923	99	107	)	)	PUNCT
admet-923	99	108	,	,	PUNCT
admet-923	99	109	(	(	PUNCT
admet-923	99	110	vi	vi	X
admet-923	99	111	)	)	PUNCT
admet-923	99	112	the	the	DET
admet-923	99	113	constancy	constancy	NOUN
admet-923	99	114	of	of	ADP
admet-923	99	115	the	the	DET
admet-923	99	116	back	back	ADV
admet-923	99	117	-	-	PUNCT
admet-923	99	118	calculated	calculate	VERB
admet-923	99	119	parameter	parameter	NOUN
admet-923	99	120	in	in	ADP
admet-923	99	121	the	the	DET
admet-923	99	122	clinical	clinical	ADJ
admet-923	99	123	and/or	and/or	CCONJ
admet-923	99	124	population	population	NOUN
admet-923	99	125	conditions	condition	NOUN
admet-923	99	126	(	(	PUNCT
admet-923	99	127	cou	cou	PROPN
admet-923	99	128	)	)	PUNCT
admet-923	99	129	to	to	PART
admet-923	99	130	be	be	AUX
admet-923	99	131	predicted	predict	VERB
admet-923	99	132	(	(	PUNCT
admet-923	99	133	sections	section	NOUN
admet-923	99	134	3.3	3.3	NUM
admet-923	99	135	and	and	CCONJ
admet-923	99	136	3.13	3.13	NUM
admet-923	99	137	)	)	PUNCT
admet-923	99	138	,	,	PUNCT
admet-923	99	139	(	(	PUNCT
admet-923	99	140	vii	vii	PROPN
admet-923	99	141	)	)	PUNCT
admet-923	99	142	the	the	DET
admet-923	99	143	validity	validity	NOUN
admet-923	99	144	of	of	ADP
admet-923	99	145	the	the	DET
admet-923	99	146	optimized	optimize	VERB
admet-923	99	147	model	model	NOUN
admet-923	99	148	(	(	PUNCT
admet-923	99	149	section	section	NOUN
admet-923	99	150	3.11	3.11	NUM
admet-923	99	151	)	)	PUNCT
admet-923	99	152	.	.	PUNCT
admet-923	100	1	1.5	1.5	NUM
admet-923	100	2	.	.	PUNCT
admet-923	100	3	references	reference	NOUN
admet-923	100	4	the	the	DET
admet-923	100	5	above	above	ADJ
admet-923	100	6	policy	policy	NOUN
admet-923	100	7	applies	apply	VERB
admet-923	100	8	to	to	ADP
admet-923	100	9	the	the	DET
admet-923	100	10	references	reference	NOUN
admet-923	100	11	.	.	PUNCT
admet-923	101	1	the	the	DET
admet-923	101	2	authors	author	NOUN
admet-923	101	3	should	should	AUX
admet-923	101	4	cite	cite	VERB
admet-923	101	5	reliable	reliable	ADJ
admet-923	101	6	articles	article	NOUN
admet-923	101	7	as	as	ADP
admet-923	101	8	references	reference	NOUN
admet-923	101	9	.	.	PUNCT
admet-923	102	1	part	part	NOUN
admet-923	102	2	2	2	NUM
admet-923	102	3	:	:	PUNCT
admet-923	102	4	scientific	scientific	ADJ
admet-923	102	5	literacy	literacy	NOUN
admet-923	102	6	for	for	ADP
admet-923	102	7	physiologically	physiologically	ADV
admet-923	102	8	-	-	PUNCT
admet-923	102	9	based	base	VERB
admet-923	102	10	pharmacokinetic	pharmacokinetic	ADJ
admet-923	102	11	modelling	modelling	NOUN
admet-923	102	12	in	in	ADP
admet-923	102	13	part	part	NOUN
admet-923	102	14	1	1	NUM
admet-923	102	15	,	,	PUNCT
admet-923	102	16	we	we	PRON
admet-923	102	17	discussed	discuss	VERB
admet-923	102	18	how	how	SCONJ
admet-923	102	19	to	to	PART
admet-923	102	20	write	write	VERB
admet-923	102	21	a	a	DET
admet-923	102	22	scientific	scientific	ADJ
admet-923	102	23	article	article	NOUN
admet-923	102	24	for	for	ADP
admet-923	102	25	pbpk	pbpk	NOUN
admet-923	102	26	modeling	modeling	NOUN
admet-923	102	27	.	.	PUNCT
admet-923	103	1	in	in	ADP
admet-923	103	2	this	this	DET
admet-923	103	3	part	part	NOUN
admet-923	103	4	,	,	PUNCT
admet-923	103	5	we	we	PRON
admet-923	103	6	will	will	AUX
admet-923	103	7	discuss	discuss	VERB
admet-923	103	8	how	how	SCONJ
admet-923	103	9	to	to	PART
admet-923	103	10	interpret	interpret	VERB
admet-923	103	11	pbpk	pbpk	ADJ
admet-923	103	12	papers	paper	NOUN
admet-923	103	13	and	and	CCONJ
admet-923	103	14	how	how	SCONJ
admet-923	103	15	to	to	PART
admet-923	103	16	evaluate	evaluate	VERB
admet-923	103	17	pbpk	pbpk	NOUN
admet-923	103	18	models	model	NOUN
admet-923	103	19	.	.	PUNCT
admet-923	104	1	physiologically	physiologically	ADV
admet-923	104	2	-	-	PUNCT
admet-923	104	3	based	base	VERB
admet-923	104	4	pharmacokinetic	pharmacokinetic	ADJ
admet-923	104	5	(	(	PUNCT
admet-923	104	6	pbpk	pbpk	NOUN
admet-923	104	7	)	)	PUNCT
admet-923	104	8	models	model	NOUN
admet-923	104	9	are	be	AUX
admet-923	104	10	not	not	PART
admet-923	104	11	as	as	ADV
admet-923	104	12	easy	easy	ADJ
admet-923	104	13	to	to	PART
admet-923	104	14	use	use	VERB
admet-923	104	15	as	as	ADP
admet-923	104	16	a	a	DET
admet-923	104	17	smartphone	smartphone	NOUN
admet-923	104	18	app	app	NOUN
admet-923	104	19	.	.	PUNCT
admet-923	105	1	as	as	SCONJ
admet-923	105	2	mentioned	mention	VERB
admet-923	105	3	in	in	ADP
admet-923	105	4	the	the	DET
admet-923	105	5	introduction	introduction	NOUN
admet-923	105	6	,	,	PUNCT
admet-923	105	7	commercial	commercial	ADJ
admet-923	105	8	pbpk	pbpk	NOUN
admet-923	105	9	software	software	NOUN
admet-923	105	10	may	may	AUX
admet-923	105	11	not	not	PART
admet-923	105	12	be	be	AUX
admet-923	105	13	so	so	ADV
admet-923	105	14	perfect	perfect	ADJ
admet-923	105	15	as	as	SCONJ
admet-923	105	16	a	a	DET
admet-923	105	17	user	user	NOUN
admet-923	105	18	might	might	AUX
admet-923	105	19	believe	believe	VERB
admet-923	105	20	[	[	X
admet-923	105	21	2–6,11,35,36	2–6,11,35,36	NUM
admet-923	105	22	]	]	PUNCT
admet-923	105	23	.	.	PUNCT
admet-923	106	1	before	before	ADP
admet-923	106	2	using	use	VERB
admet-923	106	3	a	a	DET
admet-923	106	4	pbpk	pbpk	ADJ
admet-923	106	5	model	model	NOUN
admet-923	106	6	,	,	PUNCT
admet-923	106	7	we	we	PRON
admet-923	106	8	must	must	AUX
admet-923	106	9	understand	understand	VERB
admet-923	106	10	the	the	DET
admet-923	106	11	scientific	scientific	ADJ
admet-923	106	12	literacy	literacy	NOUN
admet-923	106	13	for	for	ADP
admet-923	106	14	mathematical	mathematical	ADJ
admet-923	106	15	modelling	modelling	NOUN
admet-923	106	16	.	.	PUNCT
admet-923	107	1	in	in	ADP
admet-923	107	2	this	this	DET
admet-923	107	3	part	part	NOUN
admet-923	107	4	,	,	PUNCT
admet-923	107	5	the	the	DET
admet-923	107	6	scientific	scientific	ADJ
admet-923	107	7	literacy	literacy	NOUN
admet-923	107	8	required	require	VERB
admet-923	107	9	for	for	ADP
admet-923	107	10	pbpk	pbpk	NOUN
admet-923	107	11	modelling	modelling	NOUN
admet-923	107	12	is	be	AUX
admet-923	107	13	discussed	discuss	VERB
admet-923	107	14	.	.	PUNCT
admet-923	108	1	we	we	PRON
admet-923	108	2	are	be	AUX
admet-923	108	3	fully	fully	ADV
admet-923	108	4	aware	aware	ADJ
admet-923	108	5	that	that	SCONJ
admet-923	108	6	there	there	PRON
admet-923	108	7	are	be	VERB
admet-923	108	8	various	various	ADJ
admet-923	108	9	opinions	opinion	NOUN
admet-923	108	10	among	among	ADP
admet-923	108	11	the	the	DET
admet-923	108	12	modelers	modeler	NOUN
admet-923	108	13	on	on	ADP
admet-923	108	14	this	this	DET
admet-923	108	15	topic	topic	NOUN
admet-923	108	16	.	.	PUNCT
admet-923	109	1	the	the	DET
admet-923	109	2	purpose	purpose	NOUN
admet-923	109	3	of	of	ADP
admet-923	109	4	this	this	DET
admet-923	109	5	part	part	NOUN
admet-923	109	6	is	be	AUX
admet-923	109	7	to	to	PART
admet-923	109	8	suggest	suggest	VERB
admet-923	109	9	several	several	ADJ
admet-923	109	10	viewpoints	viewpoint	NOUN
admet-923	109	11	when	when	SCONJ
admet-923	109	12	using	use	VERB
admet-923	109	13	a	a	DET
admet-923	109	14	pbpk	pbpk	ADJ
admet-923	109	15	model	model	NOUN
admet-923	109	16	.	.	PUNCT
admet-923	110	1	2.1	2.1	NUM
admet-923	110	2	.	.	PUNCT
admet-923	111	1	the	the	DET
admet-923	111	2	basic	basic	ADJ
admet-923	111	3	concept	concept	NOUN
admet-923	111	4	of	of	ADP
admet-923	111	5	physiologically	physiologically	ADV
admet-923	111	6	-	-	PUNCT
admet-923	111	7	based	base	VERB
admet-923	111	8	pharmacokinetic	pharmacokinetic	ADJ
admet-923	111	9	models	model	NOUN
admet-923	111	10	basically	basically	ADV
admet-923	111	11	,	,	PUNCT
admet-923	111	12	a	a	DET
admet-923	111	13	pbpk	pbpk	ADJ
admet-923	111	14	model	model	NOUN
admet-923	111	15	consists	consist	VERB
admet-923	111	16	of	of	ADP
admet-923	111	17	independent	independent	ADJ
admet-923	111	18	a	a	DET
admet-923	111	19	priori	priori	ADJ
admet-923	111	20	information	information	NOUN
admet-923	111	21	of	of	ADP
admet-923	111	22	drug	drug	NOUN
admet-923	111	23	and	and	CCONJ
admet-923	111	24	formulation	formulation	NOUN
admet-923	111	25	parameters	parameter	NOUN
admet-923	111	26	,	,	PUNCT
admet-923	111	27	physiological	physiological	ADJ
admet-923	111	28	and	and	CCONJ
admet-923	111	29	biological	biological	ADJ
admet-923	111	30	parameters	parameter	NOUN
admet-923	111	31	at	at	ADP
admet-923	111	32	the	the	DET
admet-923	111	33	organ	organ	NOUN
admet-923	111	34	level	level	NOUN
admet-923	111	35	,	,	PUNCT
admet-923	111	36	and	and	CCONJ
admet-923	111	37	model	model	NOUN
admet-923	111	38	equations	equation	NOUN
admet-923	112	1	[	[	X
admet-923	112	2	37	37	NUM
admet-923	112	3	]	]	PUNCT
admet-923	112	4	.	.	PUNCT
admet-923	113	1	all	all	DET
admet-923	113	2	model	model	NOUN
admet-923	113	3	admet	admet	PROPN
admet-923	113	4	&	&	CCONJ
admet-923	113	5	dmpk	dmpk	PROPN
admet-923	113	6	9(2	9(2	NUM
admet-923	113	7	)	)	PUNCT
admet-923	113	8	(	(	PUNCT
admet-923	113	9	2021	2021	NUM
admet-923	113	10	)	)	PUNCT
admet-923	113	11	75	75	NUM
admet-923	113	12	-	-	SYM
admet-923	113	13	109	109	NUM
admet-923	113	14	lost	lose	VERB
admet-923	113	15	in	in	ADP
admet-923	113	16	modelling	modelling	NOUN
admet-923	113	17	and	and	CCONJ
admet-923	113	18	simulation	simulation	NOUN
admet-923	113	19	?	?	PUNCT
admet-923	114	1	doi	doi	NOUN
admet-923	114	2	:	:	PUNCT
admet-923	114	3	https:/doi.org/10.5599	https:/doi.org/10.5599	PROPN
admet-923	114	4	/	/	SYM
admet-923	114	5	admet.923	admet.923	PROPN
admet-923	114	6	79	79	NUM
admet-923	114	7	equations	equation	NOUN
admet-923	114	8	and	and	CCONJ
admet-923	114	9	parameters	parameter	NOUN
admet-923	114	10	have	have	VERB
admet-923	114	11	a	a	DET
admet-923	114	12	physical	physical	ADJ
admet-923	114	13	and	and	CCONJ
admet-923	114	14	physiological	physiological	ADJ
admet-923	114	15	basis	basis	NOUN
admet-923	114	16	(	(	PUNCT
admet-923	114	17	mechanistic	mechanistic	ADJ
admet-923	114	18	basis	basis	NOUN
admet-923	114	19	)	)	PUNCT
admet-923	114	20	(	(	PUNCT
admet-923	114	21	figure	figure	NOUN
admet-923	114	22	2	2	NUM
admet-923	114	23	)	)	PUNCT
admet-923	114	24	.	.	PUNCT
admet-923	115	1	pbpk	pbpk	PROPN
admet-923	115	2	models	model	NOUN
admet-923	115	3	provide	provide	VERB
admet-923	115	4	a	a	DET
admet-923	115	5	mechanistic	mechanistic	ADJ
admet-923	115	6	representation	representation	NOUN
admet-923	115	7	of	of	ADP
admet-923	115	8	pharmacokinetics	pharmacokinetic	NOUN
admet-923	115	9	and	and	CCONJ
admet-923	115	10	allow	allow	VERB
admet-923	115	11	a	a	DET
admet-923	115	12	priori	priori	ADJ
admet-923	115	13	“	"	PUNCT
admet-923	115	14	bottom	bottom	ADJ
admet-923	115	15	-	-	PUNCT
admet-923	115	16	up	up	ADP
admet-923	115	17	”	"	PUNCT
admet-923	115	18	prediction	prediction	NOUN
admet-923	115	19	of	of	ADP
admet-923	115	20	in	in	ADP
admet-923	115	21	vivo	vivo	ADJ
admet-923	115	22	pk	pk	NOUN
admet-923	115	23	profiles	profile	NOUN
admet-923	115	24	from	from	ADP
admet-923	115	25	in	in	ADP
admet-923	115	26	vitro	vitro	X
admet-923	115	27	data	datum	NOUN
admet-923	115	28	for	for	ADP
admet-923	115	29	various	various	ADJ
admet-923	115	30	clinical	clinical	ADJ
admet-923	115	31	situations	situation	NOUN
admet-923	115	32	.	.	PUNCT
admet-923	116	1	to	to	PART
admet-923	116	2	simulate	simulate	VERB
admet-923	116	3	the	the	DET
admet-923	116	4	effect	effect	NOUN
admet-923	116	5	of	of	ADP
admet-923	116	6	a	a	DET
admet-923	116	7	physiological	physiological	ADJ
admet-923	116	8	factor	factor	NOUN
admet-923	116	9	,	,	PUNCT
admet-923	116	10	the	the	DET
admet-923	116	11	model	model	NOUN
admet-923	116	12	equation	equation	NOUN
admet-923	116	13	must	must	AUX
admet-923	116	14	include	include	VERB
admet-923	116	15	the	the	DET
admet-923	116	16	factor	factor	NOUN
admet-923	116	17	as	as	ADP
admet-923	116	18	a	a	DET
admet-923	116	19	system	system	NOUN
admet-923	116	20	parameter	parameter	NOUN
admet-923	116	21	.	.	PUNCT
admet-923	117	1	as	as	ADP
admet-923	117	2	drug	drug	NOUN
admet-923	117	3	parameters	parameter	NOUN
admet-923	117	4	,	,	PUNCT
admet-923	117	5	the	the	DET
admet-923	117	6	parameters	parameter	NOUN
admet-923	117	7	that	that	PRON
admet-923	117	8	are	be	AUX
admet-923	117	9	intrinsic	intrinsic	ADJ
admet-923	117	10	to	to	ADP
admet-923	117	11	a	a	DET
admet-923	117	12	drug	drug	NOUN
admet-923	117	13	should	should	AUX
admet-923	117	14	be	be	AUX
admet-923	117	15	used	use	VERB
admet-923	117	16	.	.	PUNCT
admet-923	118	1	by	by	ADP
admet-923	118	2	combining	combine	VERB
admet-923	118	3	drug	drug	NOUN
admet-923	118	4	-	-	PUNCT
admet-923	118	5	intrinsic	intrinsic	ADJ
admet-923	118	6	parameters	parameter	NOUN
admet-923	118	7	with	with	ADP
admet-923	118	8	physiological	physiological	ADJ
admet-923	118	9	factors	factor	NOUN
admet-923	118	10	in	in	ADP
admet-923	118	11	model	model	NOUN
admet-923	118	12	equations	equation	NOUN
admet-923	118	13	,	,	PUNCT
admet-923	118	14	the	the	DET
admet-923	118	15	effects	effect	NOUN
admet-923	118	16	of	of	ADP
admet-923	118	17	physiological	physiological	ADJ
admet-923	118	18	conditions	condition	NOUN
admet-923	118	19	can	can	AUX
admet-923	118	20	be	be	AUX
admet-923	118	21	simulated	simulate	VERB
admet-923	118	22	.	.	PUNCT
admet-923	119	1	this	this	DET
admet-923	119	2	model	model	NOUN
admet-923	119	3	structure	structure	NOUN
admet-923	119	4	allows	allow	VERB
admet-923	119	5	the	the	DET
admet-923	119	6	pbpk	pbpk	PROPN
admet-923	119	7	model	model	NOUN
admet-923	119	8	to	to	PART
admet-923	119	9	handle	handle	VERB
admet-923	119	10	population	population	NOUN
admet-923	119	11	variability	variability	NOUN
admet-923	119	12	and	and	CCONJ
admet-923	119	13	physiological	physiological	ADJ
admet-923	119	14	covariates	covariate	NOUN
admet-923	119	15	.	.	PUNCT
admet-923	120	1	furthermore	furthermore	ADV
admet-923	120	2	,	,	PUNCT
admet-923	120	3	the	the	DET
admet-923	120	4	oral	oral	ADJ
admet-923	120	5	absorption	absorption	NOUN
admet-923	120	6	(	(	PUNCT
admet-923	120	7	oa	oa	INTJ
admet-923	120	8	)	)	PUNCT
admet-923	120	9	pbpk	pbpk	NOUN
admet-923	120	10	model	model	NOUN
admet-923	120	11	can	can	AUX
admet-923	120	12	account	account	VERB
admet-923	120	13	for	for	ADP
admet-923	120	14	the	the	DET
admet-923	120	15	bioequivalence	bioequivalence	NOUN
admet-923	120	16	of	of	ADP
admet-923	120	17	various	various	ADJ
admet-923	120	18	formulations	formulation	NOUN
admet-923	120	19	considering	consider	VERB
admet-923	120	20	confidence	confidence	NOUN
admet-923	120	21	intervals	interval	NOUN
admet-923	120	22	.	.	PUNCT
admet-923	121	1	this	this	DET
admet-923	121	2	point	point	NOUN
admet-923	121	3	is	be	AUX
admet-923	121	4	one	one	NUM
admet-923	121	5	of	of	ADP
admet-923	121	6	the	the	DET
admet-923	121	7	specific	specific	ADJ
admet-923	121	8	features	feature	NOUN
admet-923	121	9	that	that	PRON
admet-923	121	10	can	can	AUX
admet-923	121	11	be	be	AUX
admet-923	121	12	handled	handle	VERB
admet-923	121	13	by	by	ADP
admet-923	121	14	pbpk	pbpk	NOUN
admet-923	121	15	modelling	modelling	NOUN
admet-923	121	16	.	.	PUNCT
admet-923	122	1	figure	figure	NOUN
admet-923	122	2	2	2	NUM
admet-923	122	3	.	.	PUNCT
admet-923	122	4	overall	overall	ADJ
admet-923	122	5	prediction	prediction	NOUN
admet-923	122	6	scheme	scheme	NOUN
admet-923	122	7	of	of	ADP
admet-923	122	8	pbpk	pbpk	NOUN
admet-923	122	9	modelling	modelling	NOUN
admet-923	122	10	(	(	PUNCT
admet-923	122	11	a	a	NOUN
admet-923	122	12	)	)	PUNCT
admet-923	122	13	and	and	CCONJ
admet-923	122	14	the	the	DET
admet-923	122	15	solubility	solubility	NOUN
admet-923	122	16	model	model	NOUN
admet-923	122	17	in	in	ADP
admet-923	122	18	biorelevant	biorelevant	ADJ
admet-923	122	19	media	medium	NOUN
admet-923	122	20	for	for	ADP
admet-923	122	21	an	an	DET
admet-923	122	22	acidic	acidic	ADJ
admet-923	122	23	drug	drug	NOUN
admet-923	122	24	(	(	PUNCT
admet-923	122	25	b	b	NOUN
admet-923	122	26	)	)	PUNCT
admet-923	122	27	.	.	PUNCT
admet-923	123	1	(	(	PUNCT
admet-923	123	2	a	a	X
admet-923	123	3	)	)	PUNCT
admet-923	123	4	in	in	ADP
admet-923	123	5	vitro	vitro	X
admet-923	123	6	data	datum	NOUN
admet-923	123	7	is	be	AUX
admet-923	123	8	first	first	ADV
admet-923	123	9	reduced	reduce	VERB
admet-923	123	10	to	to	ADP
admet-923	123	11	drug	drug	VERB
admet-923	123	12	intrinsic	intrinsic	ADJ
admet-923	123	13	parameters	parameter	NOUN
admet-923	123	14	using	use	VERB
admet-923	123	15	the	the	DET
admet-923	123	16	mathematical	mathematical	ADJ
admet-923	123	17	model	model	NOUN
admet-923	123	18	of	of	ADP
admet-923	123	19	an	an	DET
admet-923	123	20	in	in	X
admet-923	123	21	vitro	vitro	X
admet-923	123	22	system	system	NOUN
admet-923	123	23	[	[	X
admet-923	123	24	38	38	NUM
admet-923	123	25	]	]	PUNCT
admet-923	123	26	.	.	PUNCT
admet-923	124	1	the	the	DET
admet-923	124	2	drug	drug	NOUN
admet-923	124	3	intrinsic	intrinsic	ADJ
admet-923	124	4	parameters	parameter	NOUN
admet-923	124	5	are	be	AUX
admet-923	124	6	then	then	ADV
admet-923	124	7	converted	convert	VERB
admet-923	124	8	to	to	ADP
admet-923	124	9	in	in	ADP
admet-923	124	10	vivo	vivo	ADJ
admet-923	124	11	pk	pk	NOUN
admet-923	124	12	profiles	profile	NOUN
admet-923	124	13	via	via	ADP
admet-923	124	14	intermediate	intermediate	ADJ
admet-923	124	15	parameters	parameter	NOUN
admet-923	124	16	(	(	PUNCT
admet-923	124	17	e.g.	e.g.	ADV
admet-923	124	18	,	,	PUNCT
admet-923	124	19	the	the	DET
admet-923	124	20	permeation	permeation	NOUN
admet-923	124	21	rate	rate	NOUN
admet-923	124	22	constant	constant	ADJ
admet-923	124	23	(	(	PUNCT
admet-923	124	24	kperm	kperm	NOUN
admet-923	124	25	)	)	PUNCT
admet-923	124	26	)	)	PUNCT
admet-923	124	27	.	.	PUNCT
admet-923	125	1	the	the	DET
admet-923	125	2	drug	drug	NOUN
admet-923	125	3	intrinsic	intrinsic	ADJ
admet-923	125	4	parameters	parameter	NOUN
admet-923	125	5	are	be	AUX
admet-923	125	6	directly	directly	ADV
admet-923	125	7	related	relate	VERB
admet-923	125	8	to	to	ADP
admet-923	125	9	a	a	DET
admet-923	125	10	chemical	chemical	NOUN
admet-923	125	11	structure	structure	NOUN
admet-923	125	12	so	so	SCONJ
admet-923	125	13	that	that	PRON
admet-923	125	14	suitable	suitable	ADJ
admet-923	125	15	for	for	ADP
admet-923	125	16	in	in	ADP
admet-923	125	17	silico	silico	NOUN
admet-923	125	18	prediction	prediction	NOUN
admet-923	125	19	and	and	CCONJ
admet-923	125	20	drug	drug	NOUN
admet-923	125	21	design	design	NOUN
admet-923	125	22	.	.	PUNCT
admet-923	126	1	(	(	PUNCT
admet-923	126	2	b	b	X
admet-923	126	3	)	)	PUNCT
admet-923	126	4	drug	drug	NOUN
admet-923	126	5	intrinsic	intrinsic	ADJ
admet-923	126	6	parameters	parameter	NOUN
admet-923	126	7	:	:	PUNCT
admet-923	126	8	purple	purple	ADJ
admet-923	126	9	,	,	PUNCT
admet-923	126	10	physiological	physiological	ADJ
admet-923	126	11	parameters	parameter	NOUN
admet-923	126	12	:	:	PUNCT
admet-923	126	13	green	green	ADJ
admet-923	126	14	,	,	PUNCT
admet-923	126	15	and	and	CCONJ
admet-923	126	16	intermediate	intermediate	ADJ
admet-923	126	17	parameter	parameter	NOUN
admet-923	126	18	:	:	PUNCT
admet-923	126	19	blue	blue	ADJ
admet-923	126	20	[	[	X
admet-923	126	21	39,40	39,40	NUM
admet-923	126	22	]	]	PUNCT
admet-923	126	23	.	.	PUNCT
admet-923	127	1	ka	ka	PROPN
admet-923	127	2	is	be	AUX
admet-923	127	3	the	the	DET
admet-923	127	4	dissociation	dissociation	NOUN
admet-923	127	5	constant	constant	ADJ
admet-923	127	6	,	,	PUNCT
admet-923	127	7	s0	s0	PROPN
admet-923	127	8	is	be	AUX
admet-923	127	9	the	the	DET
admet-923	127	10	intrinsic	intrinsic	ADJ
admet-923	127	11	solubility	solubility	NOUN
admet-923	127	12	of	of	ADP
admet-923	127	13	a	a	DET
admet-923	127	14	drug	drug	NOUN
admet-923	127	15	,	,	PUNCT
admet-923	127	16	and	and	CCONJ
admet-923	127	17	kbm,0	kbm,0	PROPN
admet-923	127	18	and	and	CCONJ
admet-923	127	19	kbm	kbm	PROPN
admet-923	127	20	,	,	PUNCT
admet-923	127	21	are	be	AUX
admet-923	127	22	the	the	DET
admet-923	127	23	bile	bile	NOUN
admet-923	127	24	micelle	micelle	NOUN
admet-923	127	25	partition	partition	NOUN
admet-923	127	26	coefficients	coefficient	NOUN
admet-923	127	27	for	for	ADP
admet-923	127	28	unionized	unionized	ADJ
admet-923	127	29	and	and	CCONJ
admet-923	127	30	anionic	anionic	ADJ
admet-923	127	31	drug	drug	NOUN
admet-923	127	32	molecular	molecular	ADJ
admet-923	127	33	species	specie	NOUN
admet-923	127	34	,	,	PUNCT
admet-923	127	35	respectively	respectively	ADV
admet-923	127	36	.	.	PUNCT
admet-923	128	1	[	[	X
admet-923	128	2	cbm	cbm	X
admet-923	128	3	]	]	X
admet-923	128	4	is	be	AUX
admet-923	128	5	the	the	DET
admet-923	128	6	bile	bile	NOUN
admet-923	128	7	micelle	micelle	NOUN
admet-923	128	8	concentration	concentration	NOUN
admet-923	128	9	,	,	PUNCT
admet-923	128	10	[	[	X
admet-923	128	11	h	h	NOUN
admet-923	128	12	+	+	X
admet-923	128	13	]	]	PUNCT
admet-923	128	14	is	be	AUX
admet-923	128	15	the	the	DET
admet-923	128	16	proton	proton	NOUN
admet-923	128	17	concentration	concentration	NOUN
admet-923	128	18	(=	(=	NOUN
admet-923	128	19	10	10	NUM
admet-923	128	20	-ph	-ph	NOUN
admet-923	128	21	)	)	PUNCT
admet-923	128	22	,	,	PUNCT
admet-923	128	23	and	and	CCONJ
admet-923	128	24	[	[	X
admet-923	128	25	h2o	h2o	X
admet-923	128	26	]	]	X
admet-923	128	27	is	be	AUX
admet-923	128	28	the	the	DET
admet-923	128	29	concentration	concentration	NOUN
admet-923	128	30	of	of	ADP
admet-923	128	31	water	water	NOUN
admet-923	128	32	.	.	PUNCT
admet-923	129	1	an	an	DET
admet-923	129	2	oa	oa	PROPN
admet-923	129	3	pbpk	pbpk	PROPN
admet-923	129	4	model	model	NOUN
admet-923	129	5	consists	consist	VERB
admet-923	129	6	of	of	ADP
admet-923	129	7	the	the	DET
admet-923	129	8	model	model	NOUN
admet-923	129	9	equations	equation	NOUN
admet-923	129	10	of	of	ADP
admet-923	129	11	solubility	solubility	NOUN
admet-923	129	12	,	,	PUNCT
admet-923	129	13	dissolution	dissolution	NOUN
admet-923	129	14	rate	rate	NOUN
admet-923	129	15	,	,	PUNCT
admet-923	129	16	permeability	permeability	NOUN
admet-923	129	17	,	,	PUNCT
admet-923	129	18	etc	etc	X
admet-923	129	19	.	.	X
admet-923	129	20	therefore	therefore	ADV
admet-923	129	21	,	,	PUNCT
admet-923	129	22	it	it	PRON
admet-923	129	23	is	be	AUX
admet-923	129	24	important	important	ADJ
admet-923	129	25	to	to	PART
admet-923	129	26	understand	understand	VERB
admet-923	129	27	these	these	DET
admet-923	129	28	equations	equation	NOUN
admet-923	129	29	before	before	ADP
admet-923	129	30	using	use	VERB
admet-923	129	31	pbpk	pbpk	NOUN
admet-923	129	32	modelling	modelling	NOUN
admet-923	129	33	(	(	PUNCT
admet-923	129	34	section	section	NOUN
admet-923	129	35	1.2	1.2	NUM
admet-923	129	36	,	,	PUNCT
admet-923	129	37	2.3	2.3	NUM
admet-923	129	38	,	,	PUNCT
admet-923	129	39	and	and	CCONJ
admet-923	129	40	2.7	2.7	NUM
admet-923	129	41	)	)	PUNCT
admet-923	129	42	.	.	PUNCT
admet-923	130	1	for	for	ADP
admet-923	130	2	example	example	NOUN
admet-923	130	3	,	,	PUNCT
admet-923	130	4	in	in	ADP
admet-923	130	5	a	a	DET
admet-923	130	6	physiologically	physiologically	ADV
admet-923	130	7	-	-	PUNCT
admet-923	130	8	based	base	VERB
admet-923	130	9	solubility	solubility	NOUN
admet-923	130	10	model	model	NOUN
admet-923	130	11	(	(	PUNCT
admet-923	130	12	figure	figure	NOUN
admet-923	130	13	2b	2b	NOUN
admet-923	130	14	)	)	PUNCT
admet-923	130	15	,	,	PUNCT
admet-923	130	16	the	the	DET
admet-923	130	17	ph	ph	NOUN
admet-923	130	18	and	and	CCONJ
admet-923	130	19	the	the	DET
admet-923	130	20	bile	bile	NOUN
admet-923	130	21	micelle	micelle	NOUN
admet-923	130	22	concentration	concentration	NOUN
admet-923	130	23	(	(	PUNCT
admet-923	130	24	cbm	cbm	PROPN
admet-923	130	25	)	)	PUNCT
admet-923	130	26	are	be	AUX
admet-923	130	27	used	use	VERB
admet-923	130	28	as	as	ADP
admet-923	130	29	physiological	physiological	ADJ
admet-923	130	30	parameters	parameter	NOUN
admet-923	130	31	,	,	PUNCT
admet-923	130	32	and	and	CCONJ
admet-923	130	33	the	the	DET
admet-923	130	34	intrinsic	intrinsic	ADJ
admet-923	130	35	solubility	solubility	NOUN
admet-923	130	36	(	(	PUNCT
admet-923	130	37	s0	s0	PROPN
admet-923	130	38	)	)	PUNCT
admet-923	130	39	,	,	PUNCT
admet-923	130	40	pka	pka	NOUN
admet-923	130	41	,	,	PUNCT
admet-923	130	42	and	and	CCONJ
admet-923	130	43	bile	bile	NOUN
admet-923	130	44	micelle	micelle	NOUN
admet-923	130	45	partition	partition	NOUN
admet-923	130	46	coefficients	coefficient	NOUN
admet-923	130	47	(	(	PUNCT
admet-923	130	48	kbm	kbm	NOUN
admet-923	130	49	)	)	PUNCT
admet-923	130	50	(	(	PUNCT
admet-923	130	51	for	for	ADP
admet-923	130	52	each	each	DET
admet-923	130	53	unionized	unionized	ADJ
admet-923	130	54	and	and	CCONJ
admet-923	130	55	ionized	ionized	ADJ
admet-923	130	56	drug	drug	NOUN
admet-923	130	57	molecules	molecule	NOUN
admet-923	130	58	)	)	PUNCT
admet-923	130	59	are	be	AUX
admet-923	130	60	used	use	VERB
admet-923	130	61	as	as	ADP
admet-923	130	62	drug	drug	NOUN
admet-923	130	63	parameters	parameter	NOUN
admet-923	130	64	[	[	X
admet-923	130	65	35,39,40	35,39,40	NUM
admet-923	130	66	]	]	PUNCT
admet-923	130	67	.	.	PUNCT
admet-923	131	1	physiologically	physiologically	ADV
admet-923	131	2	-	-	PUNCT
admet-923	131	3	based	base	VERB
admet-923	131	4	dissolution	dissolution	NOUN
admet-923	132	1	[	[	X
admet-923	132	2	41–48	41–48	NUM
admet-923	132	3	]	]	PUNCT
admet-923	132	4	and	and	CCONJ
admet-923	132	5	permeation	permeation	NOUN
admet-923	132	6	[	[	X
admet-923	132	7	49–55	49–55	NUM
admet-923	132	8	]	]	PUNCT
admet-923	132	9	models	model	NOUN
admet-923	132	10	have	have	AUX
admet-923	132	11	already	already	ADV
admet-923	132	12	been	be	AUX
admet-923	132	13	reported	report	VERB
admet-923	132	14	in	in	ADP
admet-923	132	15	the	the	DET
admet-923	132	16	literature	literature	NOUN
admet-923	132	17	and	and	CCONJ
admet-923	132	18	implemented	implement	VERB
admet-923	132	19	in	in	ADP
admet-923	132	20	some	some	DET
admet-923	132	21	oa	oa	PROPN
admet-923	132	22	pbpk	pbpk	NOUN
admet-923	132	23	models	model	NOUN
admet-923	132	24	.	.	PUNCT
admet-923	133	1	the	the	DET
admet-923	133	2	followings	following	NOUN
admet-923	133	3	are	be	AUX
admet-923	133	4	examples	example	NOUN
admet-923	133	5	of	of	ADP
admet-923	133	6	physiologically	physiologically	ADV
admet-923	133	7	-	-	PUNCT
admet-923	133	8	based	base	VERB
admet-923	133	9	dissolution	dissolution	NOUN
admet-923	133	10	and	and	CCONJ
admet-923	133	11	permeation	permeation	NOUN
admet-923	133	12	models	model	NOUN
admet-923	133	13	in	in	ADP
admet-923	133	14	the	the	DET
admet-923	133	15	simplest	simple	ADJ
admet-923	133	16	form	form	NOUN
admet-923	133	17	.	.	PUNCT
admet-923	134	1	https://doi.org/10.5599/admet.923	https://doi.org/10.5599/admet.923	X
admet-923	134	2	kiyohiko	kiyohiko	PROPN
admet-923	134	3	sugano	sugano	PROPN
admet-923	134	4	admet	admet	PROPN
admet-923	134	5	&	&	CCONJ
admet-923	134	6	dmpk	dmpk	PROPN
admet-923	134	7	9(2	9(2	NUM
admet-923	134	8	)	)	PUNCT
admet-923	134	9	(	(	PUNCT
admet-923	134	10	2021	2021	NUM
admet-923	134	11	)	)	PUNCT
admet-923	134	12	75	75	NUM
admet-923	134	13	-	-	SYM
admet-923	134	14	109	109	NUM
admet-923	134	15	80	80	NUM
admet-923	134	16	dissolution	dissolution	NOUN
admet-923	134	17	model	model	NOUN
admet-923	134	18	(	(	PUNCT
admet-923	134	19	for	for	ADP
admet-923	134	20	mono	mono	NOUN
admet-923	134	21	-	-	PUNCT
admet-923	134	22	dispersed	disperse	VERB
admet-923	134	23	spherical	spherical	ADJ
admet-923	134	24	small	small	ADJ
admet-923	134	25	particles	particle	NOUN
admet-923	134	26	)	)	PUNCT
admet-923	135	1	[	[	X
admet-923	135	2	41–48,56	41–48,56	NOUN
admet-923	135	3	]	]	PUNCT
admet-923	135	4	1/3	1/3	NUM
admet-923	135	5	2/3eff	2/3eff	NUM
admet-923	135	6	surface	surface	NOUN
admet-923	135	7	dissolv	dissolv	ADJ
admet-923	135	8	2	2	NUM
admet-923	135	9	undissolv	undissolv	ADJ
admet-923	135	10	dissolv	dissolv	ADJ
admet-923	135	11	gip	gip	PROPN
admet-923	135	12	d	d	PROPN
admet-923	135	13	3	3	NUM
admet-923	135	14	1	1	NUM
admet-923	135	15	d	d	NOUN
admet-923	135	16	undissolvx	undissolvx	NOUN
admet-923	135	17	d	d	X
admet-923	135	18	s	s	NOUN
admet-923	135	19	x	x	X
admet-923	135	20	x	x	X
admet-923	135	21	dose	dose	PROPN
admet-923	135	22	t	t	PROPN
admet-923	135	23	s	s	PROPN
admet-923	135	24	vr	vr	PROPN
admet-923	135	25			NOUN
admet-923	135	26			PROPN
admet-923	135	27			PROPN
admet-923	135	28			PROPN
admet-923	135	29			PROPN
admet-923	135	30			CCONJ
admet-923	136	1			ADJ
admet-923	136	2			NOUN
admet-923	136	3	where	where	SCONJ
admet-923	136	4	xundissolv	xundissolv	PROPN
admet-923	136	5	and	and	CCONJ
admet-923	136	6	xdissolv	xdissolv	PROPN
admet-923	136	7	are	be	AUX
admet-923	136	8	the	the	DET
admet-923	136	9	amounts	amount	NOUN
admet-923	136	10	of	of	ADP
admet-923	136	11	a	a	DET
admet-923	136	12	drug	drug	NOUN
admet-923	136	13	undissolved	undissolve	VERB
admet-923	136	14	and	and	CCONJ
admet-923	136	15	dissolved	dissolve	VERB
admet-923	136	16	in	in	ADP
admet-923	136	17	the	the	DET
admet-923	136	18	gastrointestinal	gastrointestinal	ADJ
admet-923	136	19	fluid	fluid	NOUN
admet-923	136	20	,	,	PUNCT
admet-923	136	21	respectively	respectively	ADV
admet-923	136	22	.	.	PUNCT
admet-923	137	1	deff	deff	PROPN
admet-923	137	2	is	be	AUX
admet-923	137	3	the	the	DET
admet-923	137	4	effective	effective	ADJ
admet-923	137	5	diffusion	diffusion	NOUN
admet-923	137	6	coefficient	coefficient	NOUN
admet-923	137	7	,	,	PUNCT
admet-923	137	8	dose	dose	NOUN
admet-923	137	9	is	be	AUX
admet-923	137	10	the	the	DET
admet-923	137	11	dose	dose	NOUN
admet-923	137	12	strength	strength	NOUN
admet-923	137	13	,	,	PUNCT
admet-923	137	14	ρ	ρ	PROPN
admet-923	137	15	is	be	AUX
admet-923	137	16	the	the	DET
admet-923	137	17	true	true	ADJ
admet-923	137	18	density	density	NOUN
admet-923	137	19	of	of	ADP
admet-923	137	20	the	the	DET
admet-923	137	21	drug	drug	NOUN
admet-923	137	22	substance	substance	NOUN
admet-923	137	23	,	,	PUNCT
admet-923	137	24	and	and	CCONJ
admet-923	137	25	rp	rp	NOUN
admet-923	137	26	is	be	AUX
admet-923	137	27	the	the	DET
admet-923	137	28	particle	particle	NOUN
admet-923	137	29	radius	radius	NOUN
admet-923	137	30	(	(	PUNCT
admet-923	137	31	rp	rp	NOUN
admet-923	137	32	<	<	X
admet-923	137	33	30	30	NUM
admet-923	137	34	μm	μm	NUM
admet-923	137	35	)	)	PUNCT
admet-923	137	36	.	.	PUNCT
admet-923	138	1	ssurface	ssurface	NOUN
admet-923	138	2	and	and	CCONJ
admet-923	138	3	sdissolv	sdissolv	ADJ
admet-923	138	4	are	be	AUX
admet-923	138	5	the	the	DET
admet-923	138	6	solubilities	solubility	NOUN
admet-923	138	7	of	of	ADP
admet-923	138	8	a	a	DET
admet-923	138	9	drug	drug	NOUN
admet-923	138	10	at	at	ADP
admet-923	138	11	the	the	DET
admet-923	138	12	particle	particle	NOUN
admet-923	138	13	surface	surface	NOUN
admet-923	138	14	and	and	CCONJ
admet-923	138	15	in	in	ADP
admet-923	138	16	the	the	DET
admet-923	138	17	bulk	bulk	ADJ
admet-923	138	18	fluid	fluid	NOUN
admet-923	138	19	,	,	PUNCT
admet-923	138	20	respectively	respectively	ADV
admet-923	138	21	.	.	PUNCT
admet-923	139	1	vgi	vgi	PROPN
admet-923	139	2	is	be	AUX
admet-923	139	3	the	the	DET
admet-923	139	4	gastrointestinal	gastrointestinal	ADJ
admet-923	139	5	fluid	fluid	NOUN
admet-923	139	6	volume	volume	NOUN
admet-923	139	7	.	.	PUNCT
admet-923	140	1	the	the	DET
admet-923	140	2	dissolution	dissolution	NOUN
admet-923	140	3	rate	rate	NOUN
admet-923	140	4	constant	constant	ADJ
admet-923	140	5	(	(	PUNCT
admet-923	140	6	kdiss	kdiss	ADJ
admet-923	140	7	)	)	PUNCT
admet-923	140	8	is	be	AUX
admet-923	140	9	kdiss	kdiss	ADJ
admet-923	140	10	=	=	SYM
admet-923	140	11	3	3	NUM
admet-923	140	12	deff	deff	NOUN
admet-923	140	13	ssurface/(ρrp	ssurface/(ρrp	ADJ
admet-923	140	14	2	2	NUM
admet-923	140	15	)	)	PUNCT
admet-923	140	16	.	.	PUNCT
admet-923	141	1	ssurface	ssurface	NOUN
admet-923	141	2	,	,	PUNCT
admet-923	141	3	sdissolv	sdissolv	ADJ
admet-923	141	4	,	,	PUNCT
admet-923	141	5	and	and	CCONJ
admet-923	141	6	deff	deff	PROPN
admet-923	141	7	are	be	AUX
admet-923	141	8	affected	affect	VERB
admet-923	141	9	by	by	ADP
admet-923	141	10	physiological	physiological	ADJ
admet-923	141	11	factors	factor	NOUN
admet-923	141	12	such	such	ADJ
admet-923	141	13	as	as	ADP
admet-923	141	14	ph	ph	ADJ
admet-923	141	15	,	,	PUNCT
admet-923	141	16	buffer	buffer	NOUN
admet-923	141	17	capacity	capacity	NOUN
admet-923	141	18	,	,	PUNCT
admet-923	141	19	bile	bile	NOUN
admet-923	141	20	micelle	micelle	NOUN
admet-923	141	21	concentration	concentration	NOUN
admet-923	141	22	(	(	PUNCT
admet-923	141	23	figure	figure	NOUN
admet-923	141	24	1(b	1(b	NUM
admet-923	141	25	)	)	PUNCT
admet-923	141	26	)	)	PUNCT
admet-923	141	27	.	.	PUNCT
admet-923	142	1	permeation	permeation	NOUN
admet-923	142	2	model	model	NOUN
admet-923	142	3	(	(	PUNCT
admet-923	142	4	for	for	ADP
admet-923	142	5	passive	passive	ADJ
admet-923	142	6	diffusion	diffusion	NOUN
admet-923	142	7	)	)	PUNCT
admet-923	143	1	[	[	X
admet-923	143	2	49–55	49–55	NUM
admet-923	143	3	]	]	PUNCT
admet-923	143	4	perm	perm	NOUN
admet-923	143	5	perm	perm	NOUN
admet-923	143	6	dissolv	dissolv	ADJ
admet-923	143	7	eff	eff	PROPN
admet-923	143	8	dissolv	dissolv	PROPN
admet-923	143	9	gi	gi	PROPN
admet-923	144	1	d	d	PROPN
admet-923	144	2	2	2	NUM
admet-923	144	3	d	d	NOUN
admet-923	144	4	x	x	X
admet-923	144	5	df	df	PROPN
admet-923	145	1	k	k	NOUN
admet-923	145	2	x	x	X
admet-923	146	1	p	p	X
admet-923	146	2	x	x	X
admet-923	146	3	t	t	NOUN
admet-923	146	4	r	r	NOUN
admet-923	146	5			NUM
admet-923	146	6			NOUN
admet-923	146	7			NOUN
admet-923	146	8			PROPN
admet-923	146	9	eff	eff	PROPN
admet-923	146	10	effu	effu	VERB
admet-923	146	11	0	0	NUM
admet-923	146	12	trans0	trans0	PROPN
admet-923	146	13	para	para	PROPN
admet-923	146	14	wc	wc	PROPN
admet-923	146	15	eff	eff	PROPN
admet-923	146	16	1	1	NUM
admet-923	146	17	1	1	NUM
admet-923	146	18	pe	pe	PROPN
admet-923	146	19	p	p	PROPN
admet-923	146	20	dve	dve	PROPN
admet-923	147	1	f	f	PROPN
admet-923	147	2	f	f	PROPN
admet-923	148	1	p	p	PROPN
admet-923	148	2	p	p	X
admet-923	148	3	p	p	X
admet-923	148	4	h	h	NOUN
admet-923	148	5			PROPN
admet-923	148	6			ADJ
admet-923	148	7			PROPN
admet-923	148	8			ADV
admet-923	148	9			PUNCT
admet-923	148	10	where	where	SCONJ
admet-923	148	11	xperm	xperm	NOUN
admet-923	148	12	is	be	AUX
admet-923	148	13	the	the	DET
admet-923	148	14	amounts	amount	NOUN
admet-923	148	15	of	of	ADP
admet-923	148	16	a	a	DET
admet-923	148	17	drug	drug	NOUN
admet-923	148	18	permeated	permeate	VERB
admet-923	148	19	the	the	DET
admet-923	148	20	intestinal	intestinal	ADJ
admet-923	148	21	wall	wall	NOUN
admet-923	148	22	,	,	PUNCT
admet-923	148	23	kperm	kperm	PROPN
admet-923	148	24	is	be	AUX
admet-923	148	25	the	the	DET
admet-923	148	26	permeation	permeation	NOUN
admet-923	148	27	rate	rate	NOUN
admet-923	148	28	constant	constant	ADJ
admet-923	148	29	,	,	PUNCT
admet-923	148	30	df	df	PROPN
admet-923	148	31	is	be	AUX
admet-923	148	32	the	the	DET
admet-923	148	33	degree	degree	NOUN
admet-923	148	34	of	of	ADP
admet-923	148	35	flatness	flatness	NOUN
admet-923	148	36	of	of	ADP
admet-923	148	37	the	the	DET
admet-923	148	38	small	small	ADJ
admet-923	148	39	intestinal	intestinal	ADJ
admet-923	148	40	tube	tube	NOUN
admet-923	148	41	,	,	PUNCT
admet-923	148	42	rgi	rgi	PROPN
admet-923	148	43	is	be	AUX
admet-923	148	44	the	the	DET
admet-923	148	45	radius	radius	NOUN
admet-923	148	46	,	,	PUNCT
admet-923	148	47	peff	peff	PROPN
admet-923	148	48	is	be	AUX
admet-923	148	49	the	the	DET
admet-923	148	50	effective	effective	ADJ
admet-923	148	51	intestinal	intestinal	ADJ
admet-923	148	52	membrane	membrane	NOUN
admet-923	148	53	permeability	permeability	NOUN
admet-923	148	54	,	,	PUNCT
admet-923	148	55	pe	pe	PROPN
admet-923	148	56	is	be	AUX
admet-923	148	57	the	the	DET
admet-923	148	58	plica	plica	NOUN
admet-923	148	59	expansion	expansion	NOUN
admet-923	148	60	factor	factor	NOUN
admet-923	148	61	,	,	PUNCT
admet-923	148	62	puwl	puwl	PROPN
admet-923	148	63	is	be	AUX
admet-923	148	64	the	the	DET
admet-923	148	65	uwl	uwl	NOUN
admet-923	148	66	permeability	permeability	NOUN
admet-923	148	67	,	,	PUNCT
admet-923	148	68	ve	ve	AUX
admet-923	148	69	is	be	AUX
admet-923	148	70	the	the	DET
admet-923	148	71	villi	villi	NOUN
admet-923	148	72	expansion	expansion	NOUN
admet-923	148	73	factor	factor	NOUN
admet-923	148	74	,	,	PUNCT
admet-923	148	75	fu	fu	PROPN
admet-923	148	76	is	be	AUX
admet-923	148	77	the	the	DET
admet-923	148	78	fraction	fraction	NOUN
admet-923	148	79	of	of	ADP
admet-923	148	80	unbound	unbound	NOUN
admet-923	148	81	drug	drug	NOUN
admet-923	148	82	molecule	molecule	NOUN
admet-923	148	83	species	specie	NOUN
admet-923	148	84	(	(	PUNCT
admet-923	148	85	free	free	ADJ
admet-923	148	86	fraction	fraction	NOUN
admet-923	148	87	)	)	PUNCT
admet-923	148	88	,	,	PUNCT
admet-923	148	89	f0	f0	PROPN
admet-923	148	90	is	be	AUX
admet-923	148	91	the	the	DET
admet-923	148	92	fraction	fraction	NOUN
admet-923	148	93	of	of	ADP
admet-923	148	94	undissociated	undissociated	ADJ
admet-923	148	95	drug	drug	NOUN
admet-923	148	96	molecule	molecule	NOUN
admet-923	148	97	species	specie	NOUN
admet-923	148	98	(	(	PUNCT
admet-923	148	99	calculated	calculate	VERB
admet-923	148	100	from	from	ADP
admet-923	148	101	pka	pka	PROPN
admet-923	148	102	and	and	CCONJ
admet-923	148	103	ph	ph	VERB
admet-923	148	104	)	)	PUNCT
admet-923	148	105	,	,	PUNCT
admet-923	148	106	ptrans0	ptrans0	NOUN
admet-923	148	107	is	be	AUX
admet-923	148	108	the	the	DET
admet-923	148	109	intrinsic	intrinsic	ADJ
admet-923	148	110	passive	passive	ADJ
admet-923	148	111	transcellular	transcellular	NOUN
admet-923	148	112	permeability	permeability	NOUN
admet-923	148	113	,	,	PUNCT
admet-923	148	114	ppara	ppara	NOUN
admet-923	148	115	is	be	AUX
admet-923	148	116	the	the	DET
admet-923	148	117	paracellular	paracellular	ADJ
admet-923	148	118	permeability	permeability	NOUN
admet-923	148	119	,	,	PUNCT
admet-923	148	120	heff	heff	PROPN
admet-923	148	121	is	be	AUX
admet-923	148	122	the	the	DET
admet-923	148	123	effective	effective	ADJ
admet-923	148	124	thickness	thickness	NOUN
admet-923	148	125	of	of	ADP
admet-923	148	126	the	the	DET
admet-923	148	127	uwl	uwl	NOUN
admet-923	148	128	,	,	PUNCT
admet-923	148	129	and	and	CCONJ
admet-923	148	130	pwc	pwc	NOUN
admet-923	148	131	is	be	AUX
admet-923	148	132	the	the	DET
admet-923	148	133	water	water	NOUN
admet-923	148	134	conveyance	conveyance	NOUN
admet-923	148	135	.	.	PUNCT
admet-923	149	1	instead	instead	ADV
admet-923	149	2	of	of	ADP
admet-923	149	3	using	use	VERB
admet-923	149	4	a	a	DET
admet-923	149	5	physiologically	physiologically	ADV
admet-923	149	6	-	-	PUNCT
admet-923	149	7	based	base	VERB
admet-923	149	8	mechanistic	mechanistic	ADJ
admet-923	149	9	dissolution	dissolution	PROPN
admet-923	149	10	model	model	NOUN
admet-923	149	11	,	,	PUNCT
admet-923	149	12	an	an	DET
admet-923	149	13	experimental	experimental	ADJ
admet-923	149	14	in	in	ADP
admet-923	149	15	vitro	vitro	X
admet-923	149	16	dissolution	dissolution	NOUN
admet-923	149	17	profile	profile	NOUN
admet-923	149	18	can	can	AUX
admet-923	149	19	be	be	AUX
admet-923	149	20	plugged	plug	VERB
admet-923	149	21	into	into	ADP
admet-923	149	22	an	an	DET
admet-923	149	23	oa	oa	NOUN
admet-923	149	24	pbpk	pbpk	PROPN
admet-923	149	25	model	model	NOUN
admet-923	149	26	as	as	ADP
admet-923	149	27	a	a	DET
admet-923	149	28	kind	kind	NOUN
admet-923	149	29	of	of	ADP
admet-923	149	30	intermediate	intermediate	ADJ
admet-923	149	31	parameter	parameter	NOUN
admet-923	149	32	(	(	PUNCT
admet-923	149	33	figure	figure	NOUN
admet-923	149	34	2a)[57	2a)[57	NOUN
admet-923	149	35	]	]	PUNCT
admet-923	149	36	.	.	PUNCT
admet-923	150	1	this	this	DET
admet-923	150	2	strategy	strategy	NOUN
admet-923	150	3	is	be	AUX
admet-923	150	4	often	often	ADV
admet-923	150	5	used	use	VERB
admet-923	150	6	when	when	SCONJ
admet-923	150	7	the	the	DET
admet-923	150	8	dissolution	dissolution	NOUN
admet-923	150	9	process	process	NOUN
admet-923	150	10	is	be	AUX
admet-923	150	11	the	the	DET
admet-923	150	12	key	key	ADJ
admet-923	150	13	determinant	determinant	NOUN
admet-923	150	14	of	of	ADP
admet-923	150	15	oral	oral	ADJ
admet-923	150	16	drug	drug	NOUN
admet-923	150	17	absorption	absorption	NOUN
admet-923	150	18	.	.	PUNCT
admet-923	151	1	in	in	ADP
admet-923	151	2	this	this	DET
admet-923	151	3	case	case	NOUN
admet-923	151	4	,	,	PUNCT
admet-923	151	5	the	the	DET
admet-923	151	6	dissolution	dissolution	NOUN
admet-923	151	7	profile	profile	NOUN
admet-923	151	8	is	be	AUX
admet-923	151	9	pre	pre	ADJ
admet-923	151	10	-	-	ADJ
admet-923	151	11	fixed	fixed	ADJ
admet-923	151	12	so	so	SCONJ
admet-923	151	13	that	that	SCONJ
admet-923	151	14	it	it	PRON
admet-923	151	15	is	be	AUX
admet-923	151	16	not	not	PART
admet-923	151	17	altered	alter	VERB
admet-923	151	18	by	by	ADP
admet-923	151	19	the	the	DET
admet-923	151	20	physiological	physiological	ADJ
admet-923	151	21	factors	factor	NOUN
admet-923	151	22	in	in	ADP
admet-923	151	23	the	the	DET
admet-923	151	24	computer	computer	NOUN
admet-923	151	25	simulation	simulation	NOUN
admet-923	151	26	.	.	PUNCT
admet-923	152	1	for	for	ADP
admet-923	152	2	example	example	NOUN
admet-923	152	3	,	,	PUNCT
admet-923	152	4	when	when	SCONJ
admet-923	152	5	a	a	DET
admet-923	152	6	dissolution	dissolution	NOUN
admet-923	152	7	profile	profile	NOUN
admet-923	152	8	measured	measure	VERB
admet-923	152	9	at	at	ADP
admet-923	152	10	ph	ph	PROPN
admet-923	152	11	1.2	1.2	NUM
admet-923	152	12	is	be	AUX
admet-923	152	13	plugged	plug	VERB
admet-923	152	14	into	into	ADP
admet-923	152	15	an	an	DET
admet-923	152	16	oa	oa	PROPN
admet-923	152	17	pbpk	pbpk	PROPN
admet-923	152	18	model	model	NOUN
admet-923	152	19	,	,	PUNCT
admet-923	152	20	it	it	PRON
admet-923	152	21	is	be	AUX
admet-923	152	22	not	not	PART
admet-923	152	23	changed	change	VERB
admet-923	152	24	even	even	ADV
admet-923	152	25	if	if	SCONJ
admet-923	152	26	the	the	DET
admet-923	152	27	gastric	gastric	ADJ
admet-923	152	28	ph	ph	NOUN
admet-923	152	29	value	value	NOUN
admet-923	152	30	is	be	AUX
admet-923	152	31	changed	change	VERB
admet-923	152	32	from	from	ADP
admet-923	152	33	ph	ph	PROPN
admet-923	152	34	1.2	1.2	NUM
admet-923	152	35	to	to	AUX
admet-923	152	36	ph	ph	VERB
admet-923	152	37	5.0	5.0	NUM
admet-923	152	38	in	in	ADP
admet-923	152	39	the	the	DET
admet-923	152	40	oa	oa	PROPN
admet-923	152	41	pbpk	pbpk	PROPN
admet-923	152	42	model	model	NOUN
admet-923	152	43	.	.	PUNCT
admet-923	153	1	consequently	consequently	ADV
admet-923	153	2	,	,	PUNCT
admet-923	153	3	it	it	PRON
admet-923	153	4	can	can	AUX
admet-923	153	5	not	not	PART
admet-923	153	6	account	account	VERB
admet-923	153	7	for	for	ADP
admet-923	153	8	the	the	DET
admet-923	153	9	effect	effect	NOUN
admet-923	153	10	of	of	ADP
admet-923	153	11	interor	interor	NOUN
admet-923	153	12	intrasubject	intrasubject	PROPN
admet-923	153	13	variability	variability	NOUN
admet-923	153	14	of	of	ADP
admet-923	153	15	relevant	relevant	ADJ
admet-923	153	16	physiological	physiological	ADJ
admet-923	153	17	parameters	parameter	NOUN
admet-923	153	18	on	on	ADP
admet-923	153	19	drug	drug	NOUN
admet-923	153	20	dissolution	dissolution	NOUN
admet-923	153	21	processes	process	NOUN
admet-923	153	22	.	.	PUNCT
admet-923	154	1	such	such	DET
admet-923	154	2	a	a	DET
admet-923	154	3	simulation	simulation	NOUN
admet-923	154	4	strategy	strategy	NOUN
admet-923	154	5	may	may	AUX
admet-923	154	6	be	be	AUX
admet-923	154	7	understood	understand	VERB
admet-923	154	8	as	as	ADP
admet-923	154	9	a	a	DET
admet-923	154	10	variation	variation	NOUN
admet-923	154	11	of	of	ADP
admet-923	154	12	the	the	DET
admet-923	154	13	convolution	convolution	NOUN
admet-923	154	14	method	method	NOUN
admet-923	154	15	,	,	PUNCT
admet-923	154	16	rather	rather	ADV
admet-923	154	17	than	than	ADP
admet-923	154	18	“	"	PUNCT
admet-923	154	19	physiologically	physiologically	ADV
admet-923	154	20	-	-	PUNCT
admet-923	154	21	based	base	VERB
admet-923	154	22	”	"	PUNCT
admet-923	154	23	computational	computational	ADJ
admet-923	154	24	modelling	modelling	NOUN
admet-923	154	25	(	(	PUNCT
admet-923	154	26	in	in	ADP
admet-923	154	27	the	the	DET
admet-923	154	28	case	case	NOUN
admet-923	154	29	of	of	ADP
admet-923	154	30	using	use	VERB
admet-923	154	31	in	in	ADP
admet-923	154	32	vivo	vivo	ADJ
admet-923	154	33	predictive	predictive	ADJ
admet-923	154	34	dissolution	dissolution	NOUN
admet-923	154	35	testing	testing	NOUN
admet-923	154	36	[	[	X
admet-923	154	37	58–61	58–61	NUM
admet-923	154	38	]	]	PUNCT
admet-923	154	39	,	,	PUNCT
admet-923	154	40	the	the	DET
admet-923	154	41	in	in	X
admet-923	154	42	vitro	vitro	X
admet-923	154	43	dissolution	dissolution	PROPN
admet-923	154	44	profile	profile	NOUN
admet-923	154	45	itself	itself	PRON
admet-923	154	46	is	be	AUX
admet-923	154	47	physiologically	physiologically	ADV
admet-923	154	48	-	-	PUNCT
admet-923	154	49	based	base	VERB
admet-923	154	50	)	)	PUNCT
admet-923	154	51	.	.	PUNCT
admet-923	155	1	2.2	2.2	NUM
admet-923	155	2	.	.	PUNCT
admet-923	156	1	to	to	PART
admet-923	156	2	explain	explain	VERB
admet-923	156	3	or	or	CCONJ
admet-923	156	4	to	to	PART
admet-923	156	5	predict	predict	VERB
admet-923	156	6	?	?	PUNCT
admet-923	157	1	which	which	PRON
admet-923	157	2	is	be	AUX
admet-923	157	3	the	the	DET
admet-923	157	4	position	position	NOUN
admet-923	157	5	of	of	ADP
admet-923	157	6	a	a	DET
admet-923	157	7	pbpk	pbpk	ADJ
admet-923	157	8	model	model	NOUN
admet-923	157	9	?	?	PUNCT
admet-923	158	1	the	the	DET
admet-923	158	2	purpose	purpose	NOUN
admet-923	158	3	of	of	ADP
admet-923	158	4	mathematical	mathematical	ADJ
admet-923	158	5	modeling	modeling	NOUN
admet-923	158	6	is	be	AUX
admet-923	158	7	not	not	PART
admet-923	158	8	only	only	ADV
admet-923	158	9	to	to	PART
admet-923	158	10	calculate	calculate	VERB
admet-923	158	11	the	the	DET
admet-923	158	12	predicted	predict	VERB
admet-923	158	13	values	value	NOUN
admet-923	158	14	,	,	PUNCT
admet-923	158	15	but	but	CCONJ
admet-923	158	16	also	also	ADV
admet-923	158	17	to	to	PART
admet-923	158	18	explain	explain	VERB
admet-923	158	19	the	the	DET
admet-923	158	20	observed	observe	VERB
admet-923	158	21	and	and	CCONJ
admet-923	158	22	predicted	predict	VERB
admet-923	158	23	data	datum	NOUN
admet-923	158	24	(	(	PUNCT
admet-923	158	25	understanding	understanding	NOUN
admet-923	158	26	,	,	PUNCT
admet-923	158	27	interpretation	interpretation	NOUN
admet-923	158	28	)	)	PUNCT
admet-923	159	1	[	[	X
admet-923	159	2	62	62	NUM
admet-923	159	3	]	]	PUNCT
admet-923	159	4	.	.	PUNCT
admet-923	160	1	the	the	DET
admet-923	160	2	interpretability	interpretability	NOUN
admet-923	160	3	of	of	ADP
admet-923	160	4	a	a	DET
admet-923	160	5	model	model	NOUN
admet-923	160	6	is	be	AUX
admet-923	160	7	especially	especially	ADV
admet-923	160	8	important	important	ADJ
admet-923	160	9	for	for	ADP
admet-923	160	10	medical	medical	ADJ
admet-923	160	11	applications	application	NOUN
admet-923	160	12	.	.	PUNCT
admet-923	161	1	for	for	ADP
admet-923	161	2	an	an	DET
admet-923	161	3	explanation	explanation	NOUN
admet-923	161	4	-	-	PUNCT
admet-923	161	5	oriented	orient	VERB
admet-923	161	6	model	model	NOUN
admet-923	161	7	,	,	PUNCT
admet-923	161	8	ideally	ideally	ADV
admet-923	161	9	,	,	PUNCT
admet-923	161	10	all	all	DET
admet-923	161	11	system	system	NOUN
admet-923	161	12	parameters	parameter	NOUN
admet-923	161	13	should	should	AUX
admet-923	161	14	be	be	AUX
admet-923	161	15	set	set	VERB
admet-923	161	16	based	base	VERB
admet-923	161	17	on	on	ADP
admet-923	161	18	independent	independent	ADJ
admet-923	161	19	a	a	DET
admet-923	161	20	priori	priori	ADJ
admet-923	161	21	information	information	NOUN
admet-923	161	22	.	.	PUNCT
admet-923	162	1	from	from	ADP
admet-923	162	2	the	the	DET
admet-923	162	3	viewpoint	viewpoint	NOUN
admet-923	162	4	of	of	ADP
admet-923	162	5	mathematical	mathematical	ADJ
admet-923	162	6	modelling	modelling	NOUN
admet-923	162	7	,	,	PUNCT
admet-923	162	8	pbpk	pbpk	PROPN
admet-923	162	9	models	model	NOUN
admet-923	162	10	are	be	AUX
admet-923	162	11	more	more	ADJ
admet-923	162	12	of	of	ADP
admet-923	162	13	an	an	DET
admet-923	162	14	explanation	explanation	NOUN
admet-923	162	15	-	-	PUNCT
admet-923	162	16	oriented	orient	VERB
admet-923	162	17	model	model	NOUN
admet-923	162	18	when	when	SCONJ
admet-923	162	19	compared	compare	VERB
admet-923	162	20	to	to	ADP
admet-923	162	21	more	more	ADV
admet-923	162	22	complex	complex	ADJ
admet-923	162	23	statistic	statistic	NOUN
admet-923	162	24	models	model	NOUN
admet-923	162	25	like	like	ADP
admet-923	162	26	deep	deep	ADJ
admet-923	162	27	learning	learning	NOUN
admet-923	162	28	[	[	X
admet-923	162	29	63	63	NUM
admet-923	162	30	]	]	PUNCT
admet-923	162	31	.	.	PUNCT
admet-923	163	1	in	in	ADP
admet-923	163	2	general	general	ADJ
admet-923	163	3	,	,	PUNCT
admet-923	163	4	the	the	DET
admet-923	163	5	interpretability	interpretability	NOUN
admet-923	163	6	of	of	ADP
admet-923	163	7	a	a	DET
admet-923	163	8	model	model	NOUN
admet-923	163	9	decreases	decrease	VERB
admet-923	163	10	as	as	SCONJ
admet-923	163	11	the	the	DET
admet-923	163	12	model	model	NOUN
admet-923	163	13	admet	admet	PROPN
admet-923	163	14	&	&	CCONJ
admet-923	163	15	dmpk	dmpk	PROPN
admet-923	163	16	9(2	9(2	NUM
admet-923	163	17	)	)	PUNCT
admet-923	163	18	(	(	PUNCT
admet-923	163	19	2021	2021	NUM
admet-923	163	20	)	)	PUNCT
admet-923	163	21	75	75	NUM
admet-923	163	22	-	-	SYM
admet-923	163	23	109	109	NUM
admet-923	163	24	lost	lose	VERB
admet-923	163	25	in	in	ADP
admet-923	163	26	modelling	modelling	NOUN
admet-923	163	27	and	and	CCONJ
admet-923	163	28	simulation	simulation	NOUN
admet-923	163	29	?	?	PUNCT
admet-923	164	1	doi	doi	NOUN
admet-923	164	2	:	:	PUNCT
admet-923	164	3	https:/doi.org/10.5599	https:/doi.org/10.5599	PROPN
admet-923	164	4	/	/	SYM
admet-923	164	5	admet.923	admet.923	PROPN
admet-923	164	6	81	81	NUM
admet-923	164	7	becomes	become	VERB
admet-923	164	8	more	more	ADV
admet-923	164	9	complex	complex	ADJ
admet-923	164	10	.	.	PUNCT
admet-923	165	1	simple	simple	ADJ
admet-923	165	2	models	model	NOUN
admet-923	165	3	have	have	VERB
admet-923	165	4	a	a	DET
admet-923	165	5	great	great	ADJ
admet-923	165	6	value	value	NOUN
admet-923	165	7	of	of	ADP
admet-923	165	8	“	"	PUNCT
admet-923	165	9	interpretability	interpretability	NOUN
admet-923	165	10	”	"	PUNCT
admet-923	165	11	by	by	ADP
admet-923	165	12	themselves	themselves	PRON
admet-923	165	13	[	[	X
admet-923	165	14	64	64	NUM
admet-923	165	15	]	]	PUNCT
admet-923	165	16	.	.	PUNCT
admet-923	166	1	on	on	ADP
admet-923	166	2	the	the	DET
admet-923	166	3	other	other	ADJ
admet-923	166	4	hand	hand	NOUN
admet-923	166	5	,	,	PUNCT
admet-923	166	6	complex	complex	ADJ
admet-923	166	7	models	model	NOUN
admet-923	166	8	may	may	AUX
admet-923	166	9	(	(	PUNCT
admet-923	166	10	or	or	CCONJ
admet-923	166	11	may	may	AUX
admet-923	166	12	not	not	PART
admet-923	166	13	)	)	PUNCT
admet-923	166	14	show	show	VERB
admet-923	166	15	better	well	ADJ
admet-923	166	16	predictive	predictive	ADJ
admet-923	166	17	power	power	NOUN
admet-923	166	18	(	(	PUNCT
admet-923	166	19	prediction	prediction	NOUN
admet-923	166	20	performance	performance	NOUN
admet-923	166	21	,	,	PUNCT
admet-923	166	22	generalization	generalization	NOUN
admet-923	166	23	performance	performance	NOUN
admet-923	166	24	)	)	PUNCT
admet-923	166	25	(	(	PUNCT
admet-923	166	26	section	section	NOUN
admet-923	166	27	2.8	2.8	NUM
admet-923	166	28	)	)	PUNCT
admet-923	166	29	.	.	PUNCT
admet-923	167	1	the	the	DET
admet-923	167	2	predictive	predictive	ADJ
admet-923	167	3	power	power	NOUN
admet-923	167	4	and	and	CCONJ
admet-923	167	5	description	description	NOUN
admet-923	167	6	capability	capability	NOUN
admet-923	167	7	of	of	ADP
admet-923	167	8	a	a	DET
admet-923	167	9	model	model	NOUN
admet-923	167	10	are	be	AUX
admet-923	167	11	different	different	ADJ
admet-923	167	12	.	.	PUNCT
admet-923	168	1	the	the	DET
admet-923	168	2	description	description	NOUN
admet-923	168	3	capability	capability	NOUN
admet-923	168	4	of	of	ADP
admet-923	168	5	a	a	DET
admet-923	168	6	model	model	NOUN
admet-923	168	7	is	be	AUX
admet-923	168	8	to	to	PART
admet-923	168	9	describe	describe	VERB
admet-923	168	10	existing	existing	ADJ
admet-923	168	11	data	datum	NOUN
admet-923	168	12	,	,	PUNCT
admet-923	168	13	whereas	whereas	SCONJ
admet-923	168	14	the	the	DET
admet-923	168	15	predictive	predictive	ADJ
admet-923	168	16	power	power	NOUN
admet-923	168	17	is	be	AUX
admet-923	168	18	to	to	PART
admet-923	168	19	predict	predict	VERB
admet-923	168	20	unknown	unknown	ADJ
admet-923	168	21	data	datum	NOUN
admet-923	168	22	.	.	PUNCT
admet-923	169	1	as	as	SCONJ
admet-923	169	2	a	a	DET
admet-923	169	3	model	model	NOUN
admet-923	169	4	becomes	become	VERB
admet-923	169	5	more	more	ADV
admet-923	169	6	complex	complex	ADJ
admet-923	169	7	and	and	CCONJ
admet-923	169	8	flexible	flexible	ADJ
admet-923	169	9	,	,	PUNCT
admet-923	169	10	description	description	NOUN
admet-923	169	11	capability	capability	NOUN
admet-923	169	12	always	always	ADV
admet-923	169	13	increases	increase	VERB
admet-923	169	14	.	.	PUNCT
admet-923	170	1	however	however	ADV
admet-923	170	2	,	,	PUNCT
admet-923	170	3	predictive	predictive	ADJ
admet-923	170	4	power	power	NOUN
admet-923	170	5	does	do	AUX
admet-923	170	6	not	not	PART
admet-923	170	7	always	always	ADV
admet-923	170	8	increase	increase	VERB
admet-923	170	9	,	,	PUNCT
admet-923	170	10	because	because	SCONJ
admet-923	170	11	assumptions	assumption	NOUN
admet-923	170	12	and	and	CCONJ
admet-923	170	13	errors	error	NOUN
admet-923	170	14	can	can	AUX
admet-923	170	15	accumulate	accumulate	VERB
admet-923	170	16	with	with	ADP
admet-923	170	17	the	the	DET
admet-923	170	18	increasing	increase	VERB
admet-923	170	19	complexity	complexity	NOUN
admet-923	170	20	of	of	ADP
admet-923	170	21	a	a	DET
admet-923	170	22	model	model	NOUN
admet-923	170	23	(	(	PUNCT
admet-923	170	24	sections	section	NOUN
admet-923	170	25	2.8	2.8	NUM
admet-923	170	26	and	and	CCONJ
admet-923	170	27	3.10	3.10	NUM
admet-923	170	28	)	)	PUNCT
admet-923	170	29	.	.	PUNCT
admet-923	171	1	when	when	SCONJ
admet-923	171	2	parameterization	parameterization	NOUN
admet-923	171	3	is	be	AUX
admet-923	171	4	used	use	VERB
admet-923	171	5	,	,	PUNCT
admet-923	171	6	a	a	DET
admet-923	171	7	complex	complex	ADJ
admet-923	171	8	model	model	NOUN
admet-923	171	9	is	be	AUX
admet-923	171	10	often	often	ADV
admet-923	171	11	prone	prone	ADJ
admet-923	171	12	to	to	ADP
admet-923	171	13	overfitting	overfitte	VERB
admet-923	171	14	(	(	PUNCT
admet-923	171	15	figure	figure	NOUN
admet-923	171	16	3	3	NUM
admet-923	171	17	)	)	PUNCT
admet-923	171	18	.	.	PUNCT
admet-923	172	1	in	in	ADP
admet-923	172	2	mathematical	mathematical	ADJ
admet-923	172	3	modelling	modelling	NOUN
admet-923	172	4	,	,	PUNCT
admet-923	172	5	generally	generally	ADV
admet-923	172	6	speaking	speak	VERB
admet-923	172	7	,	,	PUNCT
admet-923	172	8	to	to	PART
admet-923	172	9	compensate	compensate	VERB
admet-923	172	10	for	for	ADP
admet-923	172	11	its	its	PRON
admet-923	172	12	lesser	less	ADJ
admet-923	172	13	interpretability	interpretability	NOUN
admet-923	172	14	and	and	CCONJ
admet-923	172	15	its	its	PRON
admet-923	172	16	higher	high	ADJ
admet-923	172	17	risk	risk	NOUN
admet-923	172	18	of	of	ADP
admet-923	172	19	overfitting	overfitting	NOUN
admet-923	172	20	,	,	PUNCT
admet-923	172	21	a	a	DET
admet-923	172	22	complex	complex	ADJ
admet-923	172	23	model	model	NOUN
admet-923	172	24	should	should	AUX
admet-923	172	25	show	show	VERB
admet-923	172	26	a	a	DET
admet-923	172	27	significant	significant	ADJ
admet-923	172	28	advantage	advantage	NOUN
admet-923	172	29	over	over	ADP
admet-923	172	30	a	a	DET
admet-923	172	31	simple	simple	ADJ
admet-923	172	32	model	model	NOUN
admet-923	172	33	with	with	ADP
admet-923	172	34	respect	respect	NOUN
admet-923	172	35	to	to	ADP
admet-923	172	36	predictive	predictive	ADJ
admet-923	172	37	power	power	NOUN
admet-923	172	38	for	for	ADP
admet-923	172	39	the	the	DET
admet-923	172	40	context	context	NOUN
admet-923	172	41	of	of	ADP
admet-923	172	42	use	use	NOUN
admet-923	172	43	[	[	X
admet-923	172	44	20,64–67	20,64–67	NOUN
admet-923	172	45	]	]	X
admet-923	172	46	.	.	PUNCT
admet-923	173	1	if	if	SCONJ
admet-923	173	2	simple	simple	ADJ
admet-923	173	3	and	and	CCONJ
admet-923	173	4	complex	complex	ADJ
admet-923	173	5	models	model	NOUN
admet-923	173	6	show	show	VERB
admet-923	173	7	comparable	comparable	ADJ
admet-923	173	8	predictive	predictive	ADJ
admet-923	173	9	power	power	NOUN
admet-923	173	10	with	with	ADP
admet-923	173	11	regard	regard	NOUN
admet-923	173	12	to	to	ADP
admet-923	173	13	the	the	DET
admet-923	173	14	context	context	NOUN
admet-923	173	15	of	of	ADP
admet-923	173	16	use	use	NOUN
admet-923	173	17	,	,	PUNCT
admet-923	173	18	the	the	DET
admet-923	173	19	simple	simple	ADJ
admet-923	173	20	model	model	NOUN
admet-923	173	21	should	should	AUX
admet-923	173	22	be	be	AUX
admet-923	173	23	selected	select	VERB
admet-923	173	24	(	(	PUNCT
admet-923	173	25	cf	cf	NOUN
admet-923	173	26	.	.	PUNCT
admet-923	174	1	occam	occam	PROPN
admet-923	174	2	’s	’s	PART
admet-923	174	3	razor	razor	NOUN
admet-923	174	4	,	,	PUNCT
admet-923	174	5	the	the	DET
admet-923	174	6	principle	principle	NOUN
admet-923	174	7	of	of	ADP
admet-923	174	8	parsimony	parsimony	NOUN
admet-923	174	9	)	)	PUNCT
admet-923	175	1	[	[	X
admet-923	175	2	68	68	NUM
admet-923	175	3	]	]	PUNCT
admet-923	175	4	.	.	PUNCT
admet-923	176	1	at	at	ADP
admet-923	176	2	the	the	DET
admet-923	176	3	same	same	ADJ
admet-923	176	4	time	time	NOUN
admet-923	176	5	,	,	PUNCT
admet-923	176	6	when	when	SCONJ
admet-923	176	7	a	a	DET
admet-923	176	8	complex	complex	ADJ
admet-923	176	9	model	model	NOUN
admet-923	176	10	shows	show	VERB
admet-923	176	11	better	well	ADJ
admet-923	176	12	predictive	predictive	ADJ
admet-923	176	13	power	power	NOUN
admet-923	176	14	,	,	PUNCT
admet-923	176	15	the	the	DET
admet-923	176	16	complex	complex	ADJ
admet-923	176	17	model	model	NOUN
admet-923	176	18	should	should	AUX
admet-923	176	19	be	be	AUX
admet-923	176	20	selected	select	VERB
admet-923	176	21	(	(	PUNCT
admet-923	176	22	section	section	NOUN
admet-923	176	23	2.8	2.8	NUM
admet-923	176	24	)	)	PUNCT
admet-923	176	25	.	.	PUNCT
admet-923	177	1	figure	figure	VERB
admet-923	177	2	3	3	NUM
admet-923	177	3	.	.	PUNCT
admet-923	177	4	overfitting	overfitte	VERB
admet-923	177	5	.	.	PUNCT
admet-923	178	1	in	in	ADP
admet-923	178	2	figure	figure	NOUN
admet-923	178	3	3	3	NUM
admet-923	178	4	,	,	PUNCT
admet-923	178	5	the	the	DET
admet-923	178	6	quintic	quintic	ADJ
admet-923	178	7	equation	equation	NOUN
admet-923	178	8	perfectly	perfectly	ADV
admet-923	178	9	describes	describe	VERB
admet-923	178	10	(	(	PUNCT
admet-923	178	11	fits	fit	VERB
admet-923	178	12	)	)	PUNCT
admet-923	178	13	the	the	DET
admet-923	178	14	data	datum	NOUN
admet-923	178	15	.	.	PUNCT
admet-923	179	1	if	if	SCONJ
admet-923	179	2	the	the	DET
admet-923	179	3	experimental	experimental	ADJ
admet-923	179	4	data	data	NOUN
admet-923	179	5	is	be	AUX
admet-923	179	6	error	error	NOUN
admet-923	179	7	-	-	PUNCT
admet-923	179	8	free	free	ADJ
admet-923	179	9	,	,	PUNCT
admet-923	179	10	it	it	PRON
admet-923	179	11	is	be	AUX
admet-923	179	12	suitable	suitable	ADJ
admet-923	179	13	for	for	ADP
admet-923	179	14	predicting	predict	VERB
admet-923	179	15	unknown	unknown	ADJ
admet-923	179	16	y	y	PROPN
admet-923	179	17	from	from	ADP
admet-923	179	18	new	new	ADJ
admet-923	179	19	x	x	SYM
admet-923	179	20	data	datum	NOUN
admet-923	179	21	.	.	PUNCT
admet-923	180	1	in	in	ADP
admet-923	180	2	practice	practice	NOUN
admet-923	180	3	,	,	PUNCT
admet-923	180	4	especially	especially	ADV
admet-923	180	5	for	for	ADP
admet-923	180	6	biological	biological	ADJ
admet-923	180	7	data	datum	NOUN
admet-923	180	8	,	,	PUNCT
admet-923	180	9	there	there	PRON
admet-923	180	10	is	be	VERB
admet-923	180	11	always	always	ADV
admet-923	180	12	error	error	NOUN
admet-923	180	13	in	in	ADP
admet-923	180	14	experimental	experimental	ADJ
admet-923	180	15	data	datum	NOUN
admet-923	180	16	.	.	PUNCT
admet-923	181	1	for	for	ADP
admet-923	181	2	objective	objective	ADJ
admet-923	181	3	model	model	NOUN
admet-923	181	4	selection	selection	NOUN
admet-923	181	5	,	,	PUNCT
admet-923	181	6	statistical	statistical	ADJ
admet-923	181	7	indices	index	NOUN
admet-923	181	8	such	such	ADJ
admet-923	181	9	as	as	ADP
admet-923	181	10	the	the	DET
admet-923	181	11	akaike	akaike	ADJ
admet-923	181	12	information	information	NOUN
admet-923	181	13	criterion	criterion	NOUN
admet-923	181	14	(	(	PUNCT
admet-923	181	15	aic	aic	PROPN
admet-923	181	16	)	)	PUNCT
admet-923	181	17	can	can	AUX
admet-923	181	18	be	be	AUX
admet-923	181	19	used	use	VERB
admet-923	181	20	[	[	PUNCT
admet-923	181	21	69	69	NUM
admet-923	181	22	]	]	SYM
admet-923	181	23	.	.	PUNCT
admet-923	182	1	2.3	2.3	NUM
admet-923	182	2	.	.	PUNCT
admet-923	183	1	how	how	SCONJ
admet-923	183	2	to	to	PART
admet-923	183	3	interpret	interpret	VERB
admet-923	183	4	a	a	DET
admet-923	183	5	model	model	NOUN
admet-923	183	6	there	there	PRON
admet-923	183	7	are	be	VERB
admet-923	183	8	several	several	ADJ
admet-923	183	9	ways	way	NOUN
admet-923	183	10	to	to	PART
admet-923	183	11	interpret	interpret	VERB
admet-923	183	12	a	a	DET
admet-923	183	13	mathematical	mathematical	ADJ
admet-923	183	14	model	model	NOUN
admet-923	183	15	to	to	PART
admet-923	183	16	understand	understand	VERB
admet-923	183	17	the	the	DET
admet-923	183	18	behavior	behavior	NOUN
admet-923	183	19	of	of	ADP
admet-923	183	20	the	the	DET
admet-923	183	21	system	system	NOUN
admet-923	183	22	of	of	ADP
admet-923	183	23	interest	interest	NOUN
admet-923	183	24	.	.	PUNCT
admet-923	184	1	parameters	parameter	NOUN
admet-923	184	2	the	the	DET
admet-923	184	3	first	first	ADJ
admet-923	184	4	step	step	NOUN
admet-923	184	5	to	to	ADP
admet-923	184	6	understanding	understand	VERB
admet-923	184	7	a	a	DET
admet-923	184	8	pbpk	pbpk	ADJ
admet-923	184	9	model	model	NOUN
admet-923	184	10	is	be	AUX
admet-923	184	11	to	to	PART
admet-923	184	12	know	know	VERB
admet-923	184	13	the	the	DET
admet-923	184	14	parameters	parameter	NOUN
admet-923	184	15	that	that	PRON
admet-923	184	16	affect	affect	VERB
admet-923	184	17	the	the	DET
admet-923	184	18	physical	physical	ADJ
admet-923	184	19	and	and	CCONJ
admet-923	184	20	physiological	physiological	ADJ
admet-923	184	21	processes	process	NOUN
admet-923	184	22	.	.	PUNCT
admet-923	185	1	parameters	parameter	NOUN
admet-923	185	2	that	that	PRON
admet-923	185	3	are	be	AUX
admet-923	185	4	not	not	PART
admet-923	185	5	included	include	VERB
admet-923	185	6	in	in	ADP
admet-923	185	7	the	the	DET
admet-923	185	8	model	model	NOUN
admet-923	185	9	equation	equation	NOUN
admet-923	185	10	can	can	AUX
admet-923	185	11	not	not	PART
admet-923	185	12	be	be	AUX
admet-923	185	13	captured	capture	VERB
admet-923	185	14	by	by	ADP
admet-923	185	15	the	the	DET
admet-923	185	16	model	model	NOUN
admet-923	185	17	.	.	PUNCT
admet-923	186	1	before	before	ADP
admet-923	186	2	using	use	VERB
admet-923	186	3	a	a	DET
admet-923	186	4	pbpk	pbpk	ADJ
admet-923	186	5	model	model	NOUN
admet-923	186	6	,	,	PUNCT
admet-923	186	7	we	we	PRON
admet-923	186	8	must	must	AUX
admet-923	186	9	understand	understand	VERB
admet-923	186	10	the	the	DET
admet-923	186	11	key	key	ADJ
admet-923	186	12	factors	factor	NOUN
admet-923	186	13	that	that	PRON
admet-923	186	14	affect	affect	VERB
admet-923	186	15	the	the	DET
admet-923	186	16	pharmacokinetic	pharmacokinetic	ADJ
admet-923	186	17	processes	process	NOUN
admet-923	186	18	of	of	ADP
admet-923	186	19	a	a	DET
admet-923	186	20	drug	drug	NOUN
admet-923	186	21	(	(	PUNCT
admet-923	186	22	sections	section	NOUN
admet-923	186	23	2.1	2.1	NUM
admet-923	186	24	and	and	CCONJ
admet-923	186	25	2.7	2.7	NUM
admet-923	186	26	)	)	PUNCT
admet-923	186	27	.	.	PUNCT
admet-923	187	1	intermediate	intermediate	ADJ
admet-923	187	2	parameters	parameter	NOUN
admet-923	187	3	can	can	AUX
admet-923	187	4	be	be	AUX
admet-923	187	5	used	use	VERB
admet-923	187	6	to	to	PART
admet-923	187	7	understand	understand	VERB
admet-923	187	8	the	the	DET
admet-923	187	9	contribution	contribution	NOUN
admet-923	187	10	of	of	ADP
admet-923	187	11	each	each	DET
admet-923	187	12	process	process	NOUN
admet-923	187	13	.	.	PUNCT
admet-923	188	1	https://doi.org/10.5599/admet.923	https://doi.org/10.5599/admet.923	X
admet-923	188	2	kiyohiko	kiyohiko	PROPN
admet-923	188	3	sugano	sugano	PROPN
admet-923	188	4	admet	admet	PROPN
admet-923	188	5	&	&	CCONJ
admet-923	188	6	dmpk	dmpk	PROPN
admet-923	188	7	9(2	9(2	NUM
admet-923	188	8	)	)	PUNCT
admet-923	188	9	(	(	PUNCT
admet-923	188	10	2021	2021	NUM
admet-923	188	11	)	)	PUNCT
admet-923	188	12	75	75	NUM
admet-923	188	13	-	-	SYM
admet-923	188	14	109	109	NUM
admet-923	188	15	82	82	NUM
admet-923	188	16	mathematical	mathematical	ADJ
admet-923	188	17	structure	structure	NOUN
admet-923	188	18	a	a	DET
admet-923	188	19	mathematical	mathematical	ADJ
admet-923	188	20	structure	structure	NOUN
admet-923	188	21	represents	represent	VERB
admet-923	188	22	the	the	DET
admet-923	188	23	relationship	relationship	NOUN
admet-923	188	24	between	between	ADP
admet-923	188	25	the	the	DET
admet-923	188	26	system	system	NOUN
admet-923	188	27	parameters	parameter	NOUN
admet-923	188	28	,	,	PUNCT
admet-923	188	29	the	the	DET
admet-923	188	30	dependent	dependent	ADJ
admet-923	188	31	variables	variable	NOUN
admet-923	188	32	,	,	PUNCT
admet-923	188	33	and	and	CCONJ
admet-923	188	34	the	the	DET
admet-923	188	35	independent	independent	ADJ
admet-923	188	36	variables	variable	NOUN
admet-923	188	37	,	,	PUNCT
admet-923	188	38	for	for	ADP
admet-923	188	39	example	example	NOUN
admet-923	188	40	,	,	PUNCT
admet-923	188	41	being	be	AUX
admet-923	188	42	additive	additive	ADJ
admet-923	188	43	,	,	PUNCT
admet-923	188	44	synergistic	synergistic	ADJ
admet-923	188	45	,	,	PUNCT
admet-923	188	46	proportional	proportional	ADJ
admet-923	188	47	,	,	PUNCT
admet-923	188	48	inversely	inversely	ADV
admet-923	188	49	proportional	proportional	ADJ
admet-923	188	50	,	,	PUNCT
admet-923	188	51	exponential	exponential	NOUN
admet-923	188	52	,	,	PUNCT
admet-923	188	53	etc	etc	X
admet-923	188	54	.	.	X
admet-923	189	1	this	this	DET
admet-923	189	2	point	point	NOUN
admet-923	189	3	is	be	AUX
admet-923	189	4	important	important	ADJ
admet-923	189	5	for	for	ADP
admet-923	189	6	parameter	parameter	NOUN
admet-923	189	7	identifiability	identifiability	NOUN
admet-923	189	8	(	(	PUNCT
admet-923	189	9	see	see	VERB
admet-923	189	10	part	part	NOUN
admet-923	189	11	3	3	NUM
admet-923	189	12	)	)	PUNCT
admet-923	189	13	.	.	PUNCT
admet-923	190	1	rate	rate	NOUN
admet-923	190	2	-	-	PUNCT
admet-923	190	3	limiting	limit	VERB
admet-923	190	4	step	step	NOUN
admet-923	190	5	in	in	ADP
admet-923	190	6	any	any	DET
admet-923	190	7	kinetic	kinetic	ADJ
admet-923	190	8	model	model	NOUN
admet-923	191	1	,	,	PUNCT
admet-923	191	2	it	it	PRON
admet-923	191	3	is	be	AUX
admet-923	191	4	essential	essential	ADJ
admet-923	191	5	to	to	PART
admet-923	191	6	understand	understand	VERB
admet-923	191	7	the	the	DET
admet-923	191	8	rate	rate	NOUN
admet-923	191	9	-	-	PUNCT
admet-923	191	10	limiting	limit	VERB
admet-923	191	11	step	step	NOUN
admet-923	191	12	(	(	PUNCT
admet-923	191	13	or	or	CCONJ
admet-923	191	14	rate	rate	NOUN
admet-923	191	15	-	-	PUNCT
admet-923	191	16	limiting	limit	VERB
admet-923	191	17	parameter	parameter	NOUN
admet-923	191	18	)	)	PUNCT
admet-923	192	1	[	[	X
admet-923	192	2	70,71	70,71	NUM
admet-923	192	3	]	]	X
admet-923	192	4	.	.	PUNCT
admet-923	193	1	for	for	ADP
admet-923	193	2	example	example	NOUN
admet-923	193	3	,	,	PUNCT
admet-923	193	4	the	the	DET
admet-923	193	5	rate	rate	NOUN
admet-923	193	6	-	-	PUNCT
admet-923	193	7	limiting	limit	VERB
admet-923	193	8	step	step	NOUN
admet-923	193	9	that	that	PRON
admet-923	193	10	determines	determine	VERB
admet-923	193	11	fa	fa	INTJ
admet-923	193	12	(	(	PUNCT
admet-923	193	13	farls	farl	NOUN
admet-923	193	14	)	)	PUNCT
admet-923	193	15	can	can	AUX
admet-923	193	16	be	be	AUX
admet-923	193	17	diagnosed	diagnose	VERB
admet-923	193	18	from	from	ADP
admet-923	193	19	the	the	DET
admet-923	193	20	solubility	solubility	NOUN
admet-923	193	21	,	,	PUNCT
admet-923	193	22	dissolution	dissolution	NOUN
admet-923	193	23	,	,	PUNCT
admet-923	193	24	and	and	CCONJ
admet-923	193	25	permeation	permeation	NOUN
admet-923	193	26	numbers	number	NOUN
admet-923	193	27	[	[	X
admet-923	193	28	53,72	53,72	X
admet-923	193	29	]	]	X
admet-923	193	30	.	.	PUNCT
admet-923	194	1	from	from	ADP
admet-923	194	2	farls	farl	NOUN
admet-923	194	3	,	,	PUNCT
admet-923	194	4	the	the	DET
admet-923	194	5	sensitive	sensitive	ADJ
admet-923	194	6	parameters	parameter	NOUN
admet-923	194	7	for	for	ADP
admet-923	194	8	fa	fa	PROPN
admet-923	194	9	of	of	ADP
admet-923	194	10	a	a	DET
admet-923	194	11	drug	drug	NOUN
admet-923	194	12	can	can	AUX
admet-923	194	13	be	be	AUX
admet-923	194	14	easily	easily	ADV
admet-923	194	15	identified	identify	VERB
admet-923	194	16	.	.	PUNCT
admet-923	195	1	the	the	DET
admet-923	195	2	rate	rate	NOUN
admet-923	195	3	-	-	PUNCT
admet-923	195	4	limiting	limit	VERB
admet-923	195	5	step	step	NOUN
admet-923	195	6	of	of	ADP
admet-923	195	7	intestinal	intestinal	ADJ
admet-923	195	8	membrane	membrane	NOUN
admet-923	195	9	permeation	permeation	NOUN
admet-923	195	10	can	can	AUX
admet-923	195	11	be	be	AUX
admet-923	195	12	diagnosed	diagnose	VERB
admet-923	195	13	by	by	ADP
admet-923	195	14	using	use	VERB
admet-923	195	15	a	a	DET
admet-923	195	16	physiologically	physiologically	ADV
admet-923	195	17	-	-	PUNCT
admet-923	195	18	based	base	VERB
admet-923	195	19	permeability	permeability	NOUN
admet-923	195	20	model	model	NOUN
admet-923	196	1	[	[	X
admet-923	196	2	73,74	73,74	NOUN
admet-923	196	3	]	]	PUNCT
admet-923	196	4	.	.	PUNCT
admet-923	197	1	the	the	DET
admet-923	197	2	rate	rate	NOUN
admet-923	197	3	limiting	limit	VERB
admet-923	197	4	step	step	NOUN
admet-923	197	5	could	could	AUX
admet-923	197	6	differ	differ	VERB
admet-923	197	7	depending	depend	VERB
admet-923	197	8	on	on	ADP
admet-923	197	9	the	the	DET
admet-923	197	10	physiology	physiology	NOUN
admet-923	197	11	of	of	ADP
admet-923	197	12	each	each	DET
admet-923	197	13	subject	subject	NOUN
admet-923	197	14	.	.	PUNCT
admet-923	198	1	parameter	parameter	NOUN
admet-923	198	2	sensitivity	sensitivity	NOUN
admet-923	198	3	analysis	analysis	NOUN
admet-923	198	4	parameter	parameter	NOUN
admet-923	198	5	sensitivity	sensitivity	NOUN
admet-923	198	6	analysis	analysis	NOUN
admet-923	198	7	(	(	PUNCT
admet-923	198	8	psa	psa	NOUN
admet-923	198	9	)	)	PUNCT
admet-923	198	10	has	have	AUX
admet-923	198	11	been	be	AUX
admet-923	198	12	utilized	utilize	VERB
admet-923	198	13	to	to	PART
admet-923	198	14	interpret	interpret	VERB
admet-923	198	15	black	black	ADJ
admet-923	198	16	-	-	PUNCT
admet-923	198	17	box	box	NOUN
admet-923	198	18	models	model	NOUN
admet-923	198	19	,	,	PUNCT
admet-923	198	20	such	such	ADJ
admet-923	198	21	as	as	ADP
admet-923	198	22	deep	deep	ADJ
admet-923	198	23	learning	learning	NOUN
admet-923	198	24	.	.	PUNCT
admet-923	199	1	psa	psa	VERB
admet-923	199	2	could	could	AUX
admet-923	199	3	also	also	ADV
admet-923	199	4	be	be	AUX
admet-923	199	5	useful	useful	ADJ
admet-923	199	6	in	in	ADP
admet-923	199	7	pbpk	pbpk	NOUN
admet-923	199	8	modelling	modelling	NOUN
admet-923	199	9	.	.	PUNCT
admet-923	200	1	in	in	ADP
admet-923	200	2	pbpk	pbpk	NOUN
admet-923	200	3	modelling	modelling	NOUN
admet-923	200	4	,	,	PUNCT
admet-923	200	5	psa	psa	PROPN
admet-923	200	6	has	have	AUX
admet-923	200	7	been	be	AUX
admet-923	200	8	generally	generally	ADV
admet-923	200	9	used	use	VERB
admet-923	200	10	to	to	PART
admet-923	200	11	help	help	VERB
admet-923	200	12	deciding	decide	VERB
admet-923	200	13	which	which	PRON
admet-923	200	14	parameters	parameter	NOUN
admet-923	200	15	require	require	VERB
admet-923	200	16	further	further	ADJ
admet-923	200	17	consideration	consideration	NOUN
admet-923	200	18	either	either	CCONJ
admet-923	200	19	for	for	ADP
admet-923	200	20	additional	additional	ADJ
admet-923	200	21	in	in	ADP
admet-923	200	22	vitro	vitro	X
admet-923	200	23	measurement	measurement	NOUN
admet-923	200	24	or	or	CCONJ
admet-923	200	25	parameter	parameter	VERB
admet-923	200	26	back	back	NOUN
admet-923	200	27	-	-	PUNCT
admet-923	200	28	calculation	calculation	NOUN
admet-923	200	29	(	(	PUNCT
admet-923	200	30	section	section	NOUN
admet-923	200	31	3.5	3.5	NUM
admet-923	200	32	)	)	PUNCT
admet-923	200	33	.	.	PUNCT
admet-923	201	1	a	a	DET
admet-923	201	2	pbpk	pbpk	ADJ
admet-923	201	3	model	model	NOUN
admet-923	201	4	includes	include	VERB
admet-923	201	5	all	all	DET
admet-923	201	6	parameters	parameter	NOUN
admet-923	201	7	and	and	CCONJ
admet-923	201	8	models	model	NOUN
admet-923	201	9	,	,	PUNCT
admet-923	201	10	however	however	ADV
admet-923	201	11	some	some	PRON
admet-923	201	12	of	of	ADP
admet-923	201	13	these	these	PRON
admet-923	201	14	may	may	AUX
admet-923	201	15	have	have	VERB
admet-923	201	16	little	little	ADJ
admet-923	201	17	or	or	CCONJ
admet-923	201	18	no	no	PRON
admet-923	201	19	influence	influence	NOUN
admet-923	201	20	on	on	ADP
admet-923	201	21	the	the	DET
admet-923	201	22	outcome	outcome	NOUN
admet-923	201	23	.	.	PUNCT
admet-923	202	1	2.4	2.4	NUM
admet-923	202	2	.	.	PUNCT
admet-923	202	3	evidence	evidence	NOUN
admet-923	202	4	level	level	NOUN
admet-923	202	5	regarding	regard	VERB
admet-923	202	6	the	the	DET
admet-923	202	7	predictive	predictive	ADJ
admet-923	202	8	power	power	NOUN
admet-923	202	9	of	of	ADP
admet-923	202	10	pbpk	pbpk	NOUN
admet-923	202	11	models	model	NOUN
admet-923	202	12	the	the	DET
admet-923	202	13	predictive	predictive	ADJ
admet-923	202	14	power	power	NOUN
admet-923	202	15	of	of	ADP
admet-923	202	16	a	a	DET
admet-923	202	17	mathematical	mathematical	ADJ
admet-923	202	18	model	model	NOUN
admet-923	202	19	can	can	AUX
admet-923	202	20	be	be	AUX
admet-923	202	21	evaluated	evaluate	VERB
admet-923	202	22	based	base	VERB
admet-923	202	23	on	on	ADP
admet-923	202	24	the	the	DET
admet-923	202	25	concept	concept	NOUN
admet-923	202	26	of	of	ADP
admet-923	202	27	evidencebased	evidencebased	ADJ
admet-923	202	28	medicine	medicine	NOUN
admet-923	202	29	(	(	PUNCT
admet-923	202	30	ebm	ebm	NOUN
admet-923	202	31	)	)	PUNCT
admet-923	203	1	[	[	X
admet-923	203	2	15–17	15–17	NUM
admet-923	203	3	]	]	PUNCT
admet-923	203	4	.	.	PUNCT
admet-923	204	1	according	accord	VERB
admet-923	204	2	to	to	ADP
admet-923	204	3	ebm	ebm	PROPN
admet-923	204	4	,	,	PUNCT
admet-923	204	5	the	the	DET
admet-923	204	6	evidence	evidence	NOUN
admet-923	204	7	level	level	NOUN
admet-923	204	8	of	of	ADP
admet-923	204	9	a	a	DET
admet-923	204	10	case	case	NOUN
admet-923	204	11	study	study	NOUN
admet-923	204	12	is	be	AUX
admet-923	204	13	low	low	ADJ
admet-923	204	14	.	.	PUNCT
admet-923	205	1	case	case	NOUN
admet-923	205	2	studies	study	NOUN
admet-923	205	3	are	be	AUX
admet-923	205	4	prone	prone	ADJ
admet-923	205	5	to	to	ADP
admet-923	205	6	publication	publication	NOUN
admet-923	205	7	bias	bias	NOUN
admet-923	205	8	.	.	PUNCT
admet-923	206	1	successful	successful	ADJ
admet-923	206	2	cases	case	NOUN
admet-923	206	3	tended	tend	VERB
admet-923	206	4	to	to	PART
admet-923	206	5	be	be	AUX
admet-923	206	6	published	publish	VERB
admet-923	206	7	whereas	whereas	SCONJ
admet-923	206	8	failed	fail	VERB
admet-923	206	9	cases	case	NOUN
admet-923	206	10	are	be	AUX
admet-923	206	11	usually	usually	ADV
admet-923	206	12	not	not	PART
admet-923	206	13	published	publish	VERB
admet-923	206	14	.	.	PUNCT
admet-923	207	1	historically	historically	ADV
admet-923	207	2	,	,	PUNCT
admet-923	207	3	publication	publication	NOUN
admet-923	207	4	bias	bias	NOUN
admet-923	207	5	has	have	AUX
admet-923	207	6	caused	cause	VERB
admet-923	207	7	the	the	DET
admet-923	207	8	illusion	illusion	NOUN
admet-923	207	9	of	of	ADP
admet-923	207	10	knowledge	knowledge	NOUN
admet-923	207	11	,	,	PUNCT
admet-923	207	12	especially	especially	ADV
admet-923	207	13	in	in	ADP
admet-923	207	14	the	the	DET
admet-923	207	15	medical	medical	ADJ
admet-923	207	16	area	area	NOUN
admet-923	207	17	.	.	PUNCT
admet-923	208	1	a	a	DET
admet-923	208	2	systematic	systematic	ADJ
admet-923	208	3	study	study	NOUN
admet-923	208	4	is	be	AUX
admet-923	208	5	essential	essential	ADJ
admet-923	208	6	to	to	PART
admet-923	208	7	evaluate	evaluate	VERB
admet-923	208	8	the	the	DET
admet-923	208	9	predictive	predictive	ADJ
admet-923	208	10	power	power	NOUN
admet-923	208	11	of	of	ADP
admet-923	208	12	pbpk	pbpk	NOUN
admet-923	208	13	models	model	NOUN
admet-923	208	14	.	.	PUNCT
admet-923	209	1	for	for	ADP
admet-923	209	2	the	the	DET
admet-923	209	3	bottom	bottom	ADJ
admet-923	209	4	-	-	PUNCT
admet-923	209	5	up	up	ADP
admet-923	209	6	prediction	prediction	NOUN
admet-923	209	7	by	by	ADP
admet-923	209	8	oa	oa	PROPN
admet-923	209	9	pbpk	pbpk	PROPN
admet-923	209	10	models	model	NOUN
admet-923	209	11	,	,	PUNCT
admet-923	209	12	several	several	ADJ
admet-923	209	13	systematic	systematic	ADJ
admet-923	209	14	evaluation	evaluation	NOUN
admet-923	209	15	studies	study	NOUN
admet-923	209	16	have	have	AUX
admet-923	209	17	already	already	ADV
admet-923	209	18	been	be	AUX
admet-923	209	19	published	publish	VERB
admet-923	209	20	[	[	X
admet-923	209	21	2–5	2–5	X
admet-923	209	22	]	]	PUNCT
admet-923	209	23	.	.	PUNCT
admet-923	210	1	however	however	ADV
admet-923	210	2	,	,	PUNCT
admet-923	210	3	middle	middle	ADJ
admet-923	210	4	-	-	PUNCT
admet-923	210	5	out	out	NOUN
admet-923	210	6	approaches	approach	NOUN
admet-923	210	7	(	(	PUNCT
admet-923	210	8	see	see	VERB
admet-923	210	9	part	part	NOUN
admet-923	210	10	3	3	NUM
admet-923	210	11	)	)	PUNCT
admet-923	210	12	have	have	AUX
admet-923	210	13	been	be	AUX
admet-923	210	14	evaluated	evaluate	VERB
admet-923	210	15	mostly	mostly	ADV
admet-923	210	16	by	by	ADP
admet-923	210	17	case	case	NOUN
admet-923	210	18	studies	study	NOUN
admet-923	210	19	(	(	PUNCT
admet-923	210	20	or	or	CCONJ
admet-923	210	21	the	the	DET
admet-923	210	22	collection	collection	NOUN
admet-923	210	23	of	of	ADP
admet-923	210	24	case	case	NOUN
admet-923	210	25	studies	study	NOUN
admet-923	210	26	)	)	PUNCT
admet-923	210	27	.	.	PUNCT
admet-923	211	1	systematic	systematic	ADJ
admet-923	211	2	evaluation	evaluation	NOUN
admet-923	211	3	is	be	AUX
admet-923	211	4	required	require	VERB
admet-923	211	5	for	for	ADP
admet-923	211	6	middle	middle	ADJ
admet-923	211	7	-	-	PUNCT
admet-923	211	8	out	out	ADP
admet-923	211	9	approaches	approach	NOUN
admet-923	211	10	using	use	VERB
admet-923	211	11	a	a	DET
admet-923	211	12	standardized	standardized	ADJ
admet-923	211	13	procedure	procedure	NOUN
admet-923	211	14	(	(	PUNCT
admet-923	211	15	more	more	ADV
admet-923	211	16	precisely	precisely	ADV
admet-923	211	17	,	,	PUNCT
admet-923	211	18	for	for	ADP
admet-923	211	19	local	local	ADJ
admet-923	211	20	middle	middle	ADJ
admet-923	211	21	-	-	PUNCT
admet-923	211	22	out	out	ADP
admet-923	211	23	dynamic	dynamic	ADJ
admet-923	211	24	pbpk	pbpk	NOUN
admet-923	211	25	models	model	NOUN
admet-923	211	26	)	)	PUNCT
admet-923	212	1	[	[	X
admet-923	212	2	10,75,76	10,75,76	NUM
admet-923	212	3	]	]	PUNCT
admet-923	212	4	.	.	PUNCT
admet-923	213	1	although	although	SCONJ
admet-923	213	2	the	the	DET
admet-923	213	3	evidence	evidence	NOUN
admet-923	213	4	level	level	NOUN
admet-923	213	5	of	of	ADP
admet-923	213	6	a	a	DET
admet-923	213	7	case	case	NOUN
admet-923	213	8	study	study	NOUN
admet-923	213	9	is	be	AUX
admet-923	213	10	limited	limited	ADJ
admet-923	213	11	,	,	PUNCT
admet-923	213	12	it	it	PRON
admet-923	213	13	is	be	AUX
admet-923	213	14	still	still	ADV
admet-923	213	15	beneficial	beneficial	ADJ
admet-923	213	16	as	as	ADV
admet-923	213	17	far	far	ADV
admet-923	213	18	as	as	SCONJ
admet-923	213	19	appropriately	appropriately	ADV
admet-923	213	20	conducted	conduct	VERB
admet-923	213	21	and	and	CCONJ
admet-923	213	22	reported	report	VERB
admet-923	213	23	.	.	PUNCT
admet-923	214	1	however	however	ADV
admet-923	214	2	,	,	PUNCT
admet-923	214	3	the	the	DET
admet-923	214	4	creditability	creditability	NOUN
admet-923	214	5	of	of	ADP
admet-923	214	6	case	case	NOUN
admet-923	214	7	studies	study	NOUN
admet-923	214	8	has	have	AUX
admet-923	214	9	often	often	ADV
admet-923	214	10	been	be	AUX
admet-923	214	11	compromised	compromise	VERB
admet-923	214	12	by	by	ADP
admet-923	214	13	the	the	DET
admet-923	214	14	existence	existence	NOUN
admet-923	214	15	of	of	ADP
admet-923	214	16	a	a	DET
admet-923	214	17	black	black	ADJ
admet-923	214	18	box	box	NOUN
admet-923	214	19	in	in	ADP
admet-923	214	20	a	a	DET
admet-923	214	21	model	model	NOUN
admet-923	214	22	(	(	PUNCT
admet-923	214	23	see	see	VERB
admet-923	214	24	part	part	NOUN
admet-923	214	25	1	1	NUM
admet-923	214	26	)	)	PUNCT
admet-923	214	27	and	and	CCONJ
admet-923	214	28	inappropriate	inappropriate	ADJ
admet-923	214	29	parameter	parameter	NOUN
admet-923	214	30	optimization	optimization	NOUN
admet-923	214	31	(	(	PUNCT
admet-923	214	32	see	see	VERB
admet-923	214	33	part	part	NOUN
admet-923	214	34	3	3	NUM
admet-923	214	35	)	)	PUNCT
admet-923	215	1	[	[	X
admet-923	215	2	11	11	NUM
admet-923	215	3	]	]	PUNCT
admet-923	215	4	.	.	PUNCT
admet-923	216	1	the	the	DET
admet-923	216	2	middle	middle	ADJ
admet-923	216	3	-	-	PUNCT
admet-923	216	4	out	out	ADP
admet-923	216	5	approach	approach	NOUN
admet-923	216	6	is	be	AUX
admet-923	216	7	discussed	discuss	VERB
admet-923	216	8	in	in	ADP
admet-923	216	9	detail	detail	NOUN
admet-923	216	10	in	in	ADP
admet-923	216	11	part	part	NOUN
admet-923	216	12	3	3	NUM
admet-923	216	13	.	.	PROPN
admet-923	216	14	2.5	2.5	NUM
admet-923	216	15	.	.	PUNCT
admet-923	217	1	points	point	NOUN
admet-923	217	2	to	to	PART
admet-923	217	3	consider	consider	VERB
admet-923	217	4	for	for	ADP
admet-923	217	5	systematic	systematic	ADJ
admet-923	217	6	evaluation	evaluation	NOUN
admet-923	217	7	of	of	ADP
admet-923	217	8	predictive	predictive	ADJ
admet-923	217	9	power	power	NOUN
admet-923	217	10	dataset	dataset	NOUN
admet-923	217	11	:	:	PUNCT
admet-923	217	12	in	in	ADP
admet-923	217	13	oa	oa	ADP
admet-923	217	14	pbpk	pbpk	PROPN
admet-923	217	15	modelling	modelling	NOUN
admet-923	217	16	,	,	PUNCT
admet-923	217	17	the	the	DET
admet-923	217	18	biopharmaceutical	biopharmaceutical	ADJ
admet-923	217	19	classification	classification	NOUN
admet-923	217	20	system	system	NOUN
admet-923	217	21	(	(	PUNCT
admet-923	217	22	bcs	bcs	NOUN
admet-923	217	23	)	)	PUNCT
admet-923	217	24	can	can	AUX
admet-923	217	25	be	be	AUX
admet-923	217	26	a	a	DET
admet-923	217	27	good	good	ADJ
admet-923	217	28	starting	starting	NOUN
admet-923	217	29	point	point	NOUN
admet-923	217	30	[	[	X
admet-923	217	31	6,77,78	6,77,78	NUM
admet-923	217	32	]	]	PUNCT
admet-923	217	33	.	.	PUNCT
admet-923	218	1	a	a	DET
admet-923	218	2	test	test	NOUN
admet-923	218	3	set	set	VERB
admet-923	218	4	biased	biased	ADJ
admet-923	218	5	to	to	ADP
admet-923	218	6	bcs	bcs	NOUN
admet-923	218	7	class	class	NOUN
admet-923	218	8	i	i	PRON
admet-923	218	9	drug	drug	NOUN
admet-923	218	10	(	(	PUNCT
admet-923	218	11	high	high	ADJ
admet-923	218	12	solubility	solubility	NOUN
admet-923	218	13	/	/	SYM
admet-923	218	14	high	high	ADJ
admet-923	218	15	permeability	permeability	NOUN
admet-923	218	16	)	)	PUNCT
admet-923	218	17	should	should	AUX
admet-923	218	18	be	be	AUX
admet-923	218	19	avoided	avoid	VERB
admet-923	218	20	,	,	PUNCT
admet-923	218	21	because	because	SCONJ
admet-923	218	22	complete	complete	ADJ
admet-923	218	23	absorption	absorption	NOUN
admet-923	218	24	is	be	AUX
admet-923	218	25	easily	easily	ADV
admet-923	218	26	expected	expect	VERB
admet-923	218	27	for	for	ADP
admet-923	218	28	bcs	bcs	NOUN
admet-923	218	29	class	class	NOUN
admet-923	218	30	i	i	PRON
admet-923	218	31	drug	drug	NOUN
admet-923	218	32	.	.	PUNCT
admet-923	219	1	similarly	similarly	ADV
admet-923	219	2	,	,	PUNCT
admet-923	219	3	no	no	DET
admet-923	219	4	food	food	NOUN
admet-923	219	5	effect	effect	NOUN
admet-923	219	6	and	and	CCONJ
admet-923	219	7	no	no	DET
admet-923	219	8	gastric	gastric	ADJ
admet-923	219	9	ph	ph	ADJ
admet-923	219	10	effect	effect	NOUN
admet-923	219	11	on	on	ADP
admet-923	219	12	fa	fa	PROPN
admet-923	219	13	are	be	AUX
admet-923	219	14	expected	expect	VERB
admet-923	219	15	for	for	ADP
admet-923	219	16	bcs	bcs	NOUN
admet-923	219	17	class	class	NOUN
admet-923	219	18	i	i	PRON
admet-923	219	19	drugs	drug	VERB
admet-923	219	20	(	(	PUNCT
admet-923	219	21	but	but	CCONJ
admet-923	219	22	they	they	PRON
admet-923	219	23	could	could	AUX
admet-923	219	24	affect	affect	VERB
admet-923	219	25	cmax	cmax	NOUN
admet-923	219	26	and	and	CCONJ
admet-923	219	27	f	f	X
admet-923	219	28	)	)	PUNCT
admet-923	219	29	.	.	PUNCT
admet-923	220	1	in	in	ADP
admet-923	220	2	the	the	DET
admet-923	220	3	case	case	NOUN
admet-923	220	4	of	of	ADP
admet-923	220	5	bcs	bcs	NOUN
admet-923	220	6	class	class	NOUN
admet-923	220	7	i	i	PRON
admet-923	220	8	drugs	drug	NOUN
admet-923	220	9	,	,	PUNCT
admet-923	220	10	complex	complex	ADJ
admet-923	220	11	oa	oa	ADP
admet-923	220	12	pbpk	pbpk	NOUN
admet-923	220	13	models	model	NOUN
admet-923	220	14	may	may	AUX
admet-923	220	15	add	add	VERB
admet-923	220	16	little	little	ADJ
admet-923	220	17	advantage	advantage	NOUN
admet-923	220	18	over	over	ADP
admet-923	220	19	simple	simple	ADJ
admet-923	220	20	models	model	NOUN
admet-923	220	21	for	for	ADP
admet-923	220	22	fa	fa	NOUN
admet-923	220	23	prediction	prediction	NOUN
admet-923	220	24	(	(	PUNCT
admet-923	220	25	depending	depend	VERB
admet-923	220	26	on	on	ADP
admet-923	220	27	the	the	DET
admet-923	220	28	purpose	purpose	NOUN
admet-923	220	29	of	of	ADP
admet-923	220	30	the	the	DET
admet-923	220	31	model	model	NOUN
admet-923	220	32	)	)	PUNCT
admet-923	220	33	(	(	PUNCT
admet-923	220	34	section	section	NOUN
admet-923	220	35	2.8	2.8	NUM
admet-923	220	36	)	)	PUNCT
admet-923	220	37	.	.	PUNCT
admet-923	221	1	control	control	NOUN
admet-923	221	2	:	:	PUNCT
admet-923	221	3	a	a	DET
admet-923	221	4	simple	simple	ADJ
admet-923	221	5	model	model	NOUN
admet-923	221	6	or	or	CCONJ
admet-923	221	7	a	a	DET
admet-923	221	8	naïve	naïve	ADJ
admet-923	221	9	prediction	prediction	NOUN
admet-923	221	10	(	(	PUNCT
admet-923	221	11	figure	figure	NOUN
admet-923	221	12	4	4	NUM
admet-923	221	13	)	)	PUNCT
admet-923	221	14	should	should	AUX
admet-923	221	15	be	be	AUX
admet-923	221	16	used	use	VERB
admet-923	221	17	as	as	ADP
admet-923	221	18	a	a	DET
admet-923	221	19	control	control	NOUN
admet-923	221	20	to	to	PART
admet-923	221	21	evaluate	evaluate	VERB
admet-923	221	22	the	the	DET
admet-923	221	23	predictive	predictive	ADJ
admet-923	221	24	power	power	NOUN
admet-923	221	25	of	of	ADP
admet-923	221	26	complex	complex	ADJ
admet-923	221	27	models	model	NOUN
admet-923	221	28	[	[	X
admet-923	221	29	5,50,51,79	5,50,51,79	NOUN
admet-923	221	30	]	]	PUNCT
admet-923	221	31	.	.	PUNCT
admet-923	222	1	admet	admet	PROPN
admet-923	222	2	&	&	CCONJ
admet-923	222	3	dmpk	dmpk	PROPN
admet-923	222	4	9(2	9(2	NUM
admet-923	222	5	)	)	PUNCT
admet-923	222	6	(	(	PUNCT
admet-923	222	7	2021	2021	NUM
admet-923	222	8	)	)	PUNCT
admet-923	222	9	75	75	NUM
admet-923	222	10	-	-	SYM
admet-923	222	11	109	109	NUM
admet-923	222	12	lost	lose	VERB
admet-923	222	13	in	in	ADP
admet-923	222	14	modelling	modelling	NOUN
admet-923	222	15	and	and	CCONJ
admet-923	222	16	simulation	simulation	NOUN
admet-923	222	17	?	?	PUNCT
admet-923	223	1	doi	doi	NOUN
admet-923	223	2	:	:	PUNCT
admet-923	223	3	https:/doi.org/10.5599	https:/doi.org/10.5599	PROPN
admet-923	223	4	/	/	SYM
admet-923	223	5	admet.923	admet.923	PROPN
admet-923	223	6	83	83	NUM
admet-923	223	7	outcome	outcome	NOUN
admet-923	223	8	:	:	PUNCT
admet-923	223	9	the	the	DET
admet-923	223	10	absolute	absolute	ADJ
admet-923	223	11	bioavailability	bioavailability	NOUN
admet-923	223	12	(	(	PUNCT
admet-923	223	13	f	f	X
admet-923	223	14	)	)	PUNCT
admet-923	223	15	or	or	CCONJ
admet-923	223	16	fa	fa	PROPN
admet-923	223	17	has	have	AUX
admet-923	223	18	been	be	AUX
admet-923	223	19	used	use	VERB
admet-923	223	20	to	to	PART
admet-923	223	21	evaluate	evaluate	VERB
admet-923	223	22	oa	oa	ADP
admet-923	223	23	pbpk	pbpk	NOUN
admet-923	223	24	models	model	NOUN
admet-923	223	25	[	[	X
admet-923	223	26	2	2	NUM
admet-923	223	27	]	]	PUNCT
admet-923	223	28	.	.	PUNCT
admet-923	224	1	f	f	PROPN
admet-923	224	2	is	be	AUX
admet-923	224	3	calculated	calculate	VERB
admet-923	224	4	by	by	ADP
admet-923	224	5	subtracting	subtract	VERB
admet-923	224	6	the	the	DET
admet-923	224	7	effects	effect	NOUN
admet-923	224	8	of	of	ADP
admet-923	224	9	dose	dose	NOUN
admet-923	224	10	and	and	CCONJ
admet-923	224	11	systemic	systemic	ADJ
admet-923	224	12	clearance	clearance	NOUN
admet-923	224	13	(	(	PUNCT
admet-923	224	14	cl	cl	NOUN
admet-923	224	15	)	)	PUNCT
admet-923	224	16	from	from	ADP
admet-923	224	17	oral	oral	ADJ
admet-923	224	18	auc	auc	NOUN
admet-923	224	19	data	datum	NOUN
admet-923	224	20	using	use	VERB
admet-923	224	21	i.v	i.v	PROPN
admet-923	224	22	.	.	PUNCT
admet-923	224	23	data	data	PROPN
admet-923	224	24	(	(	PUNCT
admet-923	224	25	f	f	X
admet-923	224	26	=	=	PUNCT
admet-923	224	27	(	(	PUNCT
admet-923	224	28	aucp.o./dosep.o.)/(auci.v./dosei.v	aucp.o./dosep.o.)/(auci.v./dosei.v	PROPN
admet-923	224	29	.	.	PUNCT
admet-923	224	30	)	)	PUNCT
admet-923	224	31	)	)	PUNCT
admet-923	224	32	.	.	PUNCT
admet-923	225	1	fafg	fafg	PROPN
admet-923	225	2	can	can	AUX
admet-923	225	3	then	then	ADV
admet-923	225	4	be	be	AUX
admet-923	225	5	calculated	calculate	VERB
admet-923	225	6	from	from	ADP
admet-923	225	7	the	the	DET
admet-923	225	8	hepatic	hepatic	ADJ
admet-923	225	9	clearance	clearance	NOUN
admet-923	225	10	(	(	PUNCT
admet-923	225	11	clh	clh	NOUN
admet-923	225	12	)	)	PUNCT
admet-923	225	13	as	as	ADP
admet-923	225	14	fafg	fafg	NOUN
admet-923	225	15	=	=	SYM
admet-923	225	16	f	f	X
admet-923	225	17	/	/	SYM
admet-923	225	18	fh	fh	PROPN
admet-923	225	19	,	,	PUNCT
admet-923	225	20	fh	fh	PROPN
admet-923	226	1	=	=	SYM
admet-923	226	2	1	1	X
admet-923	226	3	–	–	PUNCT
admet-923	226	4	clh	clh	X
admet-923	226	5	/hepatic	/hepatic	ADJ
admet-923	226	6	flow	flow	NOUN
admet-923	226	7	[	[	X
admet-923	226	8	80	80	NUM
admet-923	226	9	]	]	PUNCT
admet-923	226	10	(	(	PUNCT
admet-923	226	11	fg	fg	X
admet-923	226	12	:	:	PUNCT
admet-923	226	13	the	the	DET
admet-923	226	14	fraction	fraction	NOUN
admet-923	226	15	escaping	escape	VERB
admet-923	226	16	the	the	DET
admet-923	226	17	intestinal	intestinal	ADJ
admet-923	226	18	wall	wall	NOUN
admet-923	226	19	metabolism	metabolism	NOUN
admet-923	226	20	,	,	PUNCT
admet-923	226	21	fh	fh	PROPN
admet-923	226	22	:	:	PUNCT
admet-923	226	23	the	the	DET
admet-923	226	24	fraction	fraction	NOUN
admet-923	226	25	escaping	escape	VERB
admet-923	226	26	the	the	DET
admet-923	226	27	hepatic	hepatic	ADJ
admet-923	226	28	first	first	ADJ
admet-923	226	29	-	-	PUNCT
admet-923	226	30	pass	pass	VERB
admet-923	226	31	metabolism	metabolism	NOUN
admet-923	226	32	)	)	PUNCT
admet-923	226	33	.	.	PUNCT
admet-923	227	1	in	in	ADP
admet-923	227	2	addition	addition	NOUN
admet-923	227	3	,	,	PUNCT
admet-923	227	4	there	there	PRON
admet-923	227	5	are	be	VERB
admet-923	227	6	several	several	ADJ
admet-923	227	7	methods	method	NOUN
admet-923	227	8	to	to	PART
admet-923	227	9	estimate	estimate	VERB
admet-923	227	10	fa	fa	INTJ
admet-923	227	11	from	from	ADP
admet-923	227	12	clinical	clinical	ADJ
admet-923	227	13	pk	pk	NOUN
admet-923	227	14	data	datum	NOUN
admet-923	227	15	(	(	PUNCT
admet-923	227	16	section	section	NOUN
admet-923	227	17	2.6	2.6	NUM
admet-923	227	18	)	)	PUNCT
admet-923	228	1	[	[	X
admet-923	228	2	5,81	5,81	NUM
admet-923	228	3	]	]	PUNCT
admet-923	228	4	.	.	PUNCT
admet-923	229	1	auc	auc	PROPN
admet-923	229	2	is	be	AUX
admet-923	229	3	less	less	ADV
admet-923	229	4	suitable	suitable	ADJ
admet-923	229	5	for	for	ADP
admet-923	229	6	evaluating	evaluate	VERB
admet-923	229	7	the	the	DET
admet-923	229	8	predictive	predictive	ADJ
admet-923	229	9	power	power	NOUN
admet-923	229	10	of	of	ADP
admet-923	229	11	oa	oa	PROPN
admet-923	229	12	pbpk	pbpk	PROPN
admet-923	229	13	models	model	NOUN
admet-923	229	14	because	because	SCONJ
admet-923	229	15	the	the	DET
admet-923	229	16	main	main	ADJ
admet-923	229	17	determinant	determinant	NOUN
admet-923	229	18	of	of	ADP
admet-923	229	19	auc	auc	NOUN
admet-923	229	20	is	be	AUX
admet-923	229	21	dose	dose	VERB
admet-923	229	22	and	and	CCONJ
admet-923	229	23	cl	cl	NOUN
admet-923	229	24	in	in	ADP
admet-923	229	25	many	many	ADJ
admet-923	229	26	cases	case	NOUN
admet-923	229	27	.	.	PUNCT
admet-923	230	1	statistics	statistic	NOUN
admet-923	230	2	:	:	PUNCT
admet-923	230	3	statistics	statistic	NOUN
admet-923	230	4	must	must	AUX
admet-923	230	5	be	be	AUX
admet-923	230	6	carefully	carefully	ADV
admet-923	230	7	interpreted	interpret	VERB
admet-923	230	8	.	.	PUNCT
admet-923	231	1	the	the	DET
admet-923	231	2	percentage	percentage	NOUN
admet-923	231	3	within	within	ADP
admet-923	231	4	a	a	DET
admet-923	231	5	two	two	NUM
admet-923	231	6	-	-	PUNCT
admet-923	231	7	fold	fold	NOUN
admet-923	231	8	error	error	NOUN
admet-923	231	9	is	be	AUX
admet-923	231	10	often	often	ADV
admet-923	231	11	used	use	VERB
admet-923	231	12	to	to	PART
admet-923	231	13	evaluate	evaluate	VERB
admet-923	231	14	the	the	DET
admet-923	231	15	predictability	predictability	NOUN
admet-923	231	16	of	of	ADP
admet-923	231	17	pbpk	pbpk	NOUN
admet-923	231	18	models	model	NOUN
admet-923	231	19	.	.	PUNCT
admet-923	232	1	however	however	ADV
admet-923	232	2	,	,	PUNCT
admet-923	232	3	even	even	ADV
admet-923	232	4	when	when	SCONJ
admet-923	232	5	the	the	DET
admet-923	232	6	predicted	predict	VERB
admet-923	232	7	and	and	CCONJ
admet-923	232	8	observed	observe	VERB
admet-923	232	9	f	f	PROPN
admet-923	232	10	values	value	NOUN
admet-923	232	11	are	be	AUX
admet-923	232	12	randomly	randomly	ADV
admet-923	232	13	distributed	distribute	VERB
admet-923	232	14	from	from	ADP
admet-923	232	15	0	0	NUM
admet-923	232	16	to	to	ADP
admet-923	232	17	1	1	NUM
admet-923	232	18	,	,	PUNCT
admet-923	232	19	the	the	DET
admet-923	232	20	percentage	percentage	NOUN
admet-923	232	21	within	within	ADP
admet-923	232	22	a	a	DET
admet-923	232	23	two	two	NUM
admet-923	232	24	-	-	PUNCT
admet-923	232	25	fold	fold	NOUN
admet-923	232	26	error	error	NOUN
admet-923	232	27	becomes	become	VERB
admet-923	232	28	50	50	NUM
admet-923	232	29	%	%	NOUN
admet-923	232	30	(	(	PUNCT
admet-923	232	31	figure	figure	NOUN
admet-923	232	32	4a	4a	NUM
admet-923	232	33	)	)	PUNCT
admet-923	232	34	(	(	PUNCT
admet-923	232	35	see	see	VERB
admet-923	232	36	also	also	ADV
admet-923	232	37	figures	figure	VERB
admet-923	232	38	3	3	NUM
admet-923	232	39	and	and	CCONJ
admet-923	232	40	4	4	NUM
admet-923	232	41	in	in	ADP
admet-923	232	42	[	[	X
admet-923	232	43	6	6	NUM
admet-923	232	44	]	]	PUNCT
admet-923	232	45	)	)	PUNCT
admet-923	232	46	.	.	PUNCT
admet-923	233	1	when	when	SCONJ
admet-923	233	2	predicted	predict	VERB
admet-923	233	3	as	as	ADP
admet-923	233	4	average	average	ADJ
admet-923	233	5	,	,	PUNCT
admet-923	233	6	75	75	NUM
admet-923	233	7	%	%	NOUN
admet-923	233	8	is	be	AUX
admet-923	233	9	within	within	ADP
admet-923	233	10	a	a	DET
admet-923	233	11	2	2	NUM
admet-923	233	12	-	-	ADJ
admet-923	233	13	fold	fold	ADJ
admet-923	233	14	error	error	NOUN
admet-923	233	15	(	(	PUNCT
admet-923	233	16	figure	figure	NOUN
admet-923	233	17	4b	4b	PROPN
admet-923	233	18	)	)	PUNCT
admet-923	233	19	.	.	PUNCT
admet-923	234	1	this	this	DET
admet-923	234	2	kind	kind	NOUN
admet-923	234	3	of	of	ADP
admet-923	234	4	prediction	prediction	NOUN
admet-923	234	5	is	be	AUX
admet-923	234	6	called	call	VERB
admet-923	234	7	“	"	PUNCT
admet-923	234	8	naïve	naïve	ADJ
admet-923	234	9	prediction	prediction	NOUN
admet-923	234	10	”	"	PUNCT
admet-923	234	11	.	.	PUNCT
admet-923	235	1	this	this	DET
admet-923	235	2	percentage	percentage	NOUN
admet-923	235	3	increases	increase	VERB
admet-923	235	4	when	when	SCONJ
admet-923	235	5	the	the	DET
admet-923	235	6	data	datum	NOUN
admet-923	235	7	set	set	VERB
admet-923	235	8	is	be	AUX
admet-923	235	9	biased	bias	VERB
admet-923	235	10	towards	towards	ADP
admet-923	235	11	bcs	bcs	NOUN
admet-923	235	12	class	class	NOUN
admet-923	235	13	i.	i.	NOUN
admet-923	235	14	figure	figure	NOUN
admet-923	235	15	4	4	NUM
admet-923	235	16	.	.	PUNCT
admet-923	235	17	naïve	naïve	ADJ
admet-923	235	18	prediction	prediction	NOUN
admet-923	235	19	.	.	PUNCT
admet-923	236	1	(	(	PUNCT
admet-923	236	2	a	a	X
admet-923	236	3	)	)	PUNCT
admet-923	236	4	random	random	ADJ
admet-923	236	5	prediction	prediction	NOUN
admet-923	236	6	,	,	PUNCT
admet-923	236	7	(	(	PUNCT
admet-923	236	8	b	b	NOUN
admet-923	236	9	)	)	PUNCT
admet-923	236	10	prediction	prediction	NOUN
admet-923	236	11	by	by	ADP
admet-923	236	12	average	average	ADJ
admet-923	236	13	.	.	PUNCT
admet-923	237	1	the	the	DET
admet-923	237	2	percentage	percentage	NOUN
admet-923	237	3	within	within	ADP
admet-923	237	4	a	a	DET
admet-923	237	5	twofold	twofold	NOUN
admet-923	237	6	error	error	NOUN
admet-923	237	7	is	be	AUX
admet-923	237	8	50	50	NUM
admet-923	237	9	%	%	NOUN
admet-923	237	10	for	for	ADP
admet-923	237	11	(	(	PUNCT
admet-923	237	12	a	a	NOUN
admet-923	237	13	)	)	PUNCT
admet-923	237	14	and	and	CCONJ
admet-923	237	15	75	75	NUM
admet-923	237	16	%	%	NOUN
admet-923	237	17	for	for	ADP
admet-923	237	18	(	(	PUNCT
admet-923	237	19	b	b	NOUN
admet-923	237	20	)	)	PUNCT
admet-923	237	21	.	.	PUNCT
admet-923	238	1	2.6	2.6	NUM
admet-923	238	2	.	.	PUNCT
admet-923	238	3	surrogates	surrogate	NOUN
admet-923	238	4	of	of	ADP
admet-923	238	5	fa	fa	PROPN
admet-923	238	6	data	datum	NOUN
admet-923	238	7	in	in	ADP
admet-923	238	8	oa	oa	ADP
admet-923	238	9	pbpk	pbpk	NOUN
admet-923	238	10	modelling	modelling	NOUN
admet-923	238	11	,	,	PUNCT
admet-923	238	12	the	the	DET
admet-923	238	13	fraction	fraction	NOUN
admet-923	238	14	of	of	ADP
admet-923	238	15	a	a	DET
admet-923	238	16	dose	dose	NOUN
admet-923	238	17	absorbed	absorb	VERB
admet-923	238	18	(	(	PUNCT
admet-923	238	19	fa	fa	NOUN
admet-923	238	20	)	)	PUNCT
admet-923	238	21	is	be	AUX
admet-923	238	22	an	an	DET
admet-923	238	23	important	important	ADJ
admet-923	238	24	simulation	simulation	NOUN
admet-923	238	25	output	output	NOUN
admet-923	238	26	(	(	PUNCT
admet-923	238	27	section	section	NOUN
admet-923	238	28	1.3	1.3	NUM
admet-923	238	29	)	)	PUNCT
admet-923	238	30	.	.	PUNCT
admet-923	239	1	however	however	ADV
admet-923	239	2	,	,	PUNCT
admet-923	239	3	there	there	PRON
admet-923	239	4	is	be	VERB
admet-923	239	5	no	no	DET
admet-923	239	6	exact	exact	ADJ
admet-923	239	7	method	method	NOUN
admet-923	239	8	to	to	PART
admet-923	239	9	measure	measure	VERB
admet-923	239	10	in	in	ADP
admet-923	239	11	vivo	vivo	PROPN
admet-923	239	12	fa	fa	PROPN
admet-923	239	13	.	.	PUNCT
admet-923	240	1	therefore	therefore	ADV
admet-923	240	2	,	,	PUNCT
admet-923	240	3	one	one	NUM
admet-923	240	4	or	or	CCONJ
admet-923	240	5	a	a	DET
admet-923	240	6	few	few	ADJ
admet-923	240	7	approximations	approximation	NOUN
admet-923	240	8	have	have	AUX
admet-923	240	9	been	be	AUX
admet-923	240	10	used	use	VERB
admet-923	240	11	to	to	PART
admet-923	240	12	estimate	estimate	VERB
admet-923	240	13	fa	fa	INTJ
admet-923	240	14	from	from	ADP
admet-923	240	15	in	in	ADP
admet-923	240	16	vivo	vivo	NOUN
admet-923	240	17	pk	pk	NOUN
admet-923	240	18	data	datum	NOUN
admet-923	240	19	[	[	X
admet-923	240	20	50,70,79,82–84	50,70,79,82–84	NOUN
admet-923	240	21	]	]	PUNCT
admet-923	240	22	.	.	PUNCT
admet-923	241	1	(	(	PUNCT
admet-923	241	2	a	a	X
admet-923	241	3	)	)	PUNCT
admet-923	241	4	mass	mass	ADJ
admet-923	241	5	-	-	PUNCT
admet-923	241	6	balance	balance	NOUN
admet-923	241	7	data	datum	NOUN
admet-923	241	8	using	use	VERB
admet-923	241	9	a	a	DET
admet-923	241	10	radio	radio	NOUN
admet-923	241	11	-	-	PUNCT
admet-923	241	12	labeled	label	VERB
admet-923	241	13	drug	drug	NOUN
admet-923	241	14	for	for	ADP
admet-923	241	15	i.v	i.v	PROPN
admet-923	241	16	.	.	PUNCT
admet-923	241	17	and	and	CCONJ
admet-923	241	18	p.o	p.o	PROPN
admet-923	241	19	.	.	PROPN
admet-923	241	20	(	(	PUNCT
admet-923	241	21	b	b	NOUN
admet-923	241	22	)	)	PUNCT
admet-923	241	23	from	from	ADP
admet-923	241	24	absolute	absolute	ADJ
admet-923	241	25	bioavailability	bioavailability	NOUN
admet-923	241	26	(	(	PUNCT
admet-923	241	27	f	f	NOUN
admet-923	241	28	)	)	PUNCT
admet-923	241	29	,	,	PUNCT
admet-923	241	30	hepatic	hepatic	ADJ
admet-923	241	31	clearance	clearance	NOUN
admet-923	241	32	(	(	PUNCT
admet-923	241	33	clh	clh	NOUN
admet-923	241	34	)	)	PUNCT
admet-923	241	35	,	,	PUNCT
admet-923	241	36	and	and	CCONJ
admet-923	241	37	the	the	DET
admet-923	241	38	hypothesis	hypothesis	NOUN
admet-923	241	39	of	of	ADP
admet-923	241	40	fg	fg	PROPN
admet-923	241	41	=	=	SYM
admet-923	241	42	1	1	NUM
admet-923	241	43	(	(	PUNCT
admet-923	241	44	section	section	NOUN
admet-923	241	45	3.8	3.8	NUM
admet-923	241	46	(	(	PUNCT
admet-923	241	47	v	v	NOUN
admet-923	241	48	)	)	PUNCT
admet-923	241	49	)	)	PUNCT
admet-923	241	50	.	.	PUNCT
admet-923	242	1	(	(	PUNCT
admet-923	242	2	c	c	X
admet-923	242	3	)	)	PUNCT
admet-923	242	4	relative	relative	ADJ
admet-923	242	5	bioavailability	bioavailability	NOUN
admet-923	242	6	of	of	ADP
admet-923	242	7	solution	solution	NOUN
admet-923	242	8	vs.	vs.	ADP
admet-923	242	9	solid	solid	ADJ
admet-923	242	10	formulation	formulation	NOUN
admet-923	242	11	.	.	PUNCT
admet-923	243	1	(	(	PUNCT
admet-923	243	2	d	d	X
admet-923	243	3	)	)	PUNCT
admet-923	243	4	relative	relative	ADJ
admet-923	243	5	bioavailability	bioavailability	NOUN
admet-923	243	6	in	in	ADP
admet-923	243	7	the	the	DET
admet-923	243	8	fasted	fasted	ADJ
admet-923	243	9	state	state	NOUN
admet-923	243	10	vs.	vs.	ADP
admet-923	243	11	the	the	DET
admet-923	243	12	fed	fed	PROPN
admet-923	243	13	state	state	NOUN
admet-923	243	14	(	(	PUNCT
admet-923	243	15	when	when	SCONJ
admet-923	243	16	do	do	AUX
admet-923	243	17	<	<	X
admet-923	243	18	1	1	NUM
admet-923	243	19	in	in	ADP
admet-923	243	20	the	the	DET
admet-923	243	21	fed	fed	PROPN
admet-923	243	22	state	state	NOUN
admet-923	243	23	)	)	PUNCT
admet-923	243	24	(	(	PUNCT
admet-923	243	25	do	do	AUX
admet-923	243	26	:	:	PUNCT
admet-923	243	27	the	the	DET
admet-923	243	28	dose	dose	NOUN
admet-923	243	29	number	number	NOUN
admet-923	243	30	(	(	PUNCT
admet-923	243	31	dose/	dose/	NUM
admet-923	243	32	(	(	PUNCT
admet-923	243	33	s	s	PROPN
admet-923	243	34	×vsi	×vsi	NOUN
admet-923	243	35	)	)	PUNCT
admet-923	243	36	)	)	PUNCT
admet-923	243	37	,	,	PUNCT
admet-923	243	38	s	s	X
admet-923	243	39	:	:	PUNCT
admet-923	243	40	solubility	solubility	NOUN
admet-923	243	41	,	,	PUNCT
admet-923	243	42	vsi	vsi	PROPN
admet-923	243	43	:	:	PUNCT
admet-923	243	44	small	small	ADJ
admet-923	243	45	intestinal	intestinal	ADJ
admet-923	243	46	fluid	fluid	NOUN
admet-923	243	47	volume	volume	NOUN
admet-923	243	48	)	)	PUNCT
admet-923	243	49	.	.	PUNCT
admet-923	244	1	(	(	PUNCT
admet-923	244	2	e	e	NOUN
admet-923	244	3	)	)	PUNCT
admet-923	244	4	relative	relative	ADJ
admet-923	244	5	bioavailability	bioavailability	NOUN
admet-923	244	6	between	between	ADP
admet-923	244	7	the	the	DET
admet-923	244	8	dose	dose	NOUN
admet-923	244	9	strengths	strength	NOUN
admet-923	244	10	where	where	SCONJ
admet-923	244	11	do	do	VERB
admet-923	244	12	<	<	X
admet-923	244	13	1	1	NUM
admet-923	244	14	and	and	CCONJ
admet-923	244	15	do	do	VERB
admet-923	244	16	>	>	X
admet-923	244	17	1	1	NUM
admet-923	244	18	(	(	PUNCT
admet-923	244	19	auc	auc	NOUN
admet-923	244	20	can	can	AUX
admet-923	244	21	be	be	AUX
admet-923	244	22	corrected	correct	VERB
admet-923	244	23	by	by	ADP
admet-923	244	24	elimination	elimination	NOUN
admet-923	244	25	t1/2	t1/2	NOUN
admet-923	244	26	for	for	ADP
admet-923	244	27	nonlinear	nonlinear	ADJ
admet-923	244	28	clearance	clearance	NOUN
admet-923	244	29	drugs	drug	NOUN
admet-923	244	30	)	)	PUNCT
admet-923	244	31	.	.	PUNCT
admet-923	245	1	the	the	DET
admet-923	245	2	mass	mass	ADJ
admet-923	245	3	-	-	PUNCT
admet-923	245	4	balance	balance	NOUN
admet-923	245	5	data	datum	NOUN
admet-923	245	6	would	would	AUX
admet-923	245	7	be	be	AUX
admet-923	245	8	the	the	DET
admet-923	245	9	most	most	ADV
admet-923	245	10	reliable	reliable	ADJ
admet-923	245	11	data	datum	NOUN
admet-923	245	12	to	to	PART
admet-923	245	13	estimate	estimate	VERB
admet-923	245	14	fa	fa	NOUN
admet-923	245	15	.	.	PUNCT
admet-923	246	1	however	however	ADV
admet-923	246	2	,	,	PUNCT
admet-923	246	3	these	these	DET
admet-923	246	4	data	datum	NOUN
admet-923	246	5	are	be	AUX
admet-923	246	6	rarely	rarely	ADV
admet-923	246	7	available	available	ADJ
admet-923	246	8	.	.	PUNCT
admet-923	247	1	when	when	SCONJ
admet-923	247	2	i.v	i.v	PROPN
admet-923	247	3	.	.	PROPN
admet-923	247	4	data	data	PROPN
admet-923	247	5	is	be	AUX
admet-923	247	6	available	available	ADJ
admet-923	247	7	,	,	PUNCT
admet-923	247	8	we	we	PRON
admet-923	247	9	can	can	AUX
admet-923	247	10	estimate	estimate	VERB
admet-923	247	11	fafg	fafg	NOUN
admet-923	247	12	from	from	ADP
admet-923	247	13	f	f	PROPN
admet-923	247	14	and	and	CCONJ
admet-923	247	15	clh	clh	NOUN
admet-923	247	16	.	.	PUNCT
admet-923	248	1	when	when	SCONJ
admet-923	248	2	i.v	i.v	PROPN
admet-923	248	3	.	.	PROPN
admet-923	248	4	data	datum	NOUN
admet-923	248	5	are	be	AUX
admet-923	248	6	not	not	PART
admet-923	248	7	available	available	ADJ
admet-923	248	8	,	,	PUNCT
admet-923	248	9	https://doi.org/10.5599/admet.923	https://doi.org/10.5599/admet.923	X
admet-923	248	10	kiyohiko	kiyohiko	PROPN
admet-923	248	11	sugano	sugano	PROPN
admet-923	248	12	admet	admet	PROPN
admet-923	248	13	&	&	CCONJ
admet-923	248	14	dmpk	dmpk	PROPN
admet-923	248	15	9(2	9(2	NUM
admet-923	248	16	)	)	PUNCT
admet-923	248	17	(	(	PUNCT
admet-923	248	18	2021	2021	NUM
admet-923	248	19	)	)	PUNCT
admet-923	248	20	75	75	NUM
admet-923	248	21	-	-	SYM
admet-923	248	22	109	109	NUM
admet-923	248	23	84	84	NUM
admet-923	248	24	for	for	ADP
admet-923	248	25	high	high	ADJ
admet-923	248	26	permeability	permeability	NOUN
admet-923	248	27	drugs	drug	NOUN
admet-923	248	28	,	,	PUNCT
admet-923	248	29	the	the	DET
admet-923	248	30	relative	relative	ADJ
admet-923	248	31	bioavailability	bioavailability	NOUN
admet-923	248	32	to	to	ADP
admet-923	248	33	an	an	DET
admet-923	248	34	oral	oral	ADJ
admet-923	248	35	formulation	formulation	NOUN
admet-923	248	36	that	that	PRON
admet-923	248	37	eliminates	eliminate	VERB
admet-923	248	38	the	the	DET
admet-923	248	39	effect	effect	NOUN
admet-923	248	40	of	of	ADP
admet-923	248	41	solubility	solubility	NOUN
admet-923	248	42	and	and	CCONJ
admet-923	248	43	dissolution	dissolution	NOUN
admet-923	248	44	(	(	PUNCT
admet-923	248	45	(	(	PUNCT
admet-923	248	46	c)-(e	c)-(e	NOUN
admet-923	248	47	)	)	PUNCT
admet-923	248	48	)	)	PUNCT
admet-923	248	49	can	can	AUX
admet-923	248	50	be	be	AUX
admet-923	248	51	used	use	VERB
admet-923	248	52	as	as	ADP
admet-923	248	53	a	a	DET
admet-923	248	54	surrogate	surrogate	NOUN
admet-923	248	55	of	of	ADP
admet-923	248	56	fa	fa	PROPN
admet-923	248	57	(	(	PUNCT
admet-923	248	58	cf	cf	NOUN
admet-923	248	59	.	.	PUNCT
admet-923	249	1	in	in	ADP
admet-923	249	2	this	this	DET
admet-923	249	3	case	case	NOUN
admet-923	249	4	,	,	PUNCT
admet-923	249	5	the	the	DET
admet-923	249	6	effects	effect	NOUN
admet-923	249	7	of	of	ADP
admet-923	249	8	fg	fg	PROPN
admet-923	249	9	and	and	CCONJ
admet-923	249	10	fh	fh	PROPN
admet-923	249	11	are	be	AUX
admet-923	249	12	canceled	cancel	VERB
admet-923	249	13	out	out	ADP
admet-923	249	14	)	)	PUNCT
admet-923	249	15	.	.	PUNCT
admet-923	250	1	the	the	DET
admet-923	250	2	permeability	permeability	NOUN
admet-923	250	3	category	category	NOUN
admet-923	250	4	(	(	PUNCT
admet-923	250	5	low	low	ADJ
admet-923	250	6	/	/	SYM
admet-923	250	7	high	high	ADJ
admet-923	250	8	)	)	PUNCT
admet-923	250	9	can	can	AUX
admet-923	250	10	be	be	AUX
admet-923	250	11	reliably	reliably	ADV
admet-923	250	12	diagnosed	diagnose	VERB
admet-923	250	13	by	by	ADP
admet-923	250	14	in	in	ADP
admet-923	250	15	vitro	vitro	X
admet-923	250	16	permeability	permeability	NOUN
admet-923	250	17	assays	assay	NOUN
admet-923	250	18	[	[	X
admet-923	250	19	85	85	NUM
admet-923	250	20	]	]	PUNCT
admet-923	250	21	.	.	PUNCT
admet-923	251	1	in	in	ADP
admet-923	251	2	the	the	DET
admet-923	251	3	case	case	NOUN
admet-923	251	4	of	of	ADP
admet-923	251	5	high	high	ADJ
admet-923	251	6	papp	papp	NOUN
admet-923	251	7	drugs	drug	NOUN
admet-923	251	8	(	(	PUNCT
admet-923	251	9	>	>	X
admet-923	251	10	metoprolol	metoprolol	PROPN
admet-923	251	11	papp	papp	NOUN
admet-923	251	12	at	at	ADP
admet-923	251	13	ph	ph	PROPN
admet-923	251	14	6.5	6.5	NUM
admet-923	251	15	,	,	PUNCT
admet-923	251	16	metoprolol	metoprolol	NOUN
admet-923	251	17	log	log	NOUN
admet-923	251	18	dph6.5	dph6.5	NUM
admet-923	251	19	=	=	SYM
admet-923	251	20	-1.1)[86	-1.1)[86	PROPN
admet-923	251	21	]	]	PUNCT
admet-923	251	22	,	,	PUNCT
admet-923	251	23	fa	fa	PROPN
admet-923	251	24	will	will	AUX
admet-923	251	25	be	be	AUX
admet-923	251	26	greater	great	ADJ
admet-923	251	27	than	than	ADP
admet-923	251	28	0.8	0.8	NUM
admet-923	251	29	with	with	ADP
admet-923	251	30	a	a	DET
admet-923	251	31	very	very	ADV
admet-923	251	32	high	high	ADJ
admet-923	251	33	probability	probability	NOUN
admet-923	251	34	when	when	SCONJ
admet-923	251	35	there	there	PRON
admet-923	251	36	is	be	VERB
admet-923	251	37	no	no	DET
admet-923	251	38	solubility	solubility	NOUN
admet-923	251	39	and	and	CCONJ
admet-923	251	40	dissolution	dissolution	NOUN
admet-923	251	41	limitation	limitation	NOUN
admet-923	251	42	.	.	PUNCT
admet-923	252	1	based	base	VERB
admet-923	252	2	on	on	ADP
admet-923	252	3	this	this	DET
admet-923	252	4	high	high	ADJ
admet-923	252	5	reliability	reliability	NOUN
admet-923	252	6	,	,	PUNCT
admet-923	252	7	caco-2	caco-2	NUM
admet-923	252	8	papp	papp	NOUN
admet-923	252	9	data	datum	NOUN
admet-923	252	10	has	have	AUX
admet-923	252	11	been	be	AUX
admet-923	252	12	used	use	VERB
admet-923	252	13	for	for	ADP
admet-923	252	14	regulatory	regulatory	ADJ
admet-923	252	15	biowaiver	biowaiver	NOUN
admet-923	252	16	submission	submission	NOUN
admet-923	252	17	(	(	PUNCT
admet-923	252	18	note	note	NOUN
admet-923	252	19	:	:	PUNCT
admet-923	252	20	for	for	ADP
admet-923	252	21	highly	highly	ADV
admet-923	252	22	lipophilic	lipophilic	ADJ
admet-923	252	23	drugs	drug	NOUN
admet-923	252	24	(	(	PUNCT
admet-923	252	25	log	log	NOUN
admet-923	252	26	dph6.5	dph6.5	VERB
admet-923	252	27	>	>	X
admet-923	252	28	1.5	1.5	NUM
admet-923	252	29	)	)	PUNCT
admet-923	252	30	,	,	PUNCT
admet-923	252	31	the	the	DET
admet-923	252	32	caco-2	caco-2	NUM
admet-923	252	33	assay	assay	NOUN
admet-923	252	34	may	may	AUX
admet-923	252	35	underestimate	underestimate	VERB
admet-923	252	36	the	the	DET
admet-923	252	37	permeability	permeability	NOUN
admet-923	252	38	of	of	ADP
admet-923	252	39	the	the	DET
admet-923	252	40	drug	drug	NOUN
admet-923	252	41	due	due	ADP
admet-923	252	42	to	to	ADP
admet-923	252	43	experimental	experimental	ADJ
admet-923	252	44	artifacts	artifact	NOUN
admet-923	252	45	such	such	ADJ
admet-923	252	46	as	as	ADP
admet-923	252	47	membrane	membrane	NOUN
admet-923	252	48	binding	binding	NOUN
admet-923	252	49	[	[	X
admet-923	252	50	87,88	87,88	NOUN
admet-923	252	51	]	]	PUNCT
admet-923	252	52	,	,	PUNCT
admet-923	252	53	leading	lead	VERB
admet-923	252	54	to	to	ADP
admet-923	252	55	a	a	DET
admet-923	252	56	misassignment	misassignment	NOUN
admet-923	252	57	of	of	ADP
admet-923	252	58	a	a	DET
admet-923	252	59	drug	drug	NOUN
admet-923	252	60	as	as	ADP
admet-923	252	61	low	low	ADJ
admet-923	252	62	permeability	permeability	NOUN
admet-923	252	63	(	(	PUNCT
admet-923	252	64	this	this	PRON
admet-923	252	65	can	can	AUX
admet-923	252	66	be	be	AUX
admet-923	252	67	identified	identify	VERB
admet-923	252	68	by	by	ADP
admet-923	252	69	a	a	DET
admet-923	252	70	mass	mass	NOUN
admet-923	252	71	balance	balance	NOUN
admet-923	252	72	study	study	NOUN
admet-923	252	73	in	in	ADP
admet-923	252	74	caco-2	caco-2	NOUN
admet-923	252	75	)	)	PUNCT
admet-923	252	76	.	.	PUNCT
admet-923	253	1	in	in	ADP
admet-923	253	2	this	this	DET
admet-923	253	3	lipophilicity	lipophilicity	NOUN
admet-923	253	4	range	range	NOUN
admet-923	253	5	,	,	PUNCT
admet-923	253	6	the	the	DET
admet-923	253	7	diffusion	diffusion	NOUN
admet-923	253	8	through	through	ADP
admet-923	253	9	the	the	DET
admet-923	253	10	unstirred	unstirred	ADJ
admet-923	253	11	water	water	NOUN
admet-923	253	12	layer	layer	NOUN
admet-923	253	13	becomes	become	VERB
admet-923	253	14	the	the	DET
admet-923	253	15	rate	rate	NOUN
admet-923	253	16	-	-	PUNCT
admet-923	253	17	limiting	limit	VERB
admet-923	253	18	step	step	NOUN
admet-923	253	19	of	of	ADP
admet-923	253	20	in	in	ADP
admet-923	253	21	vivo	vivo	ADJ
admet-923	253	22	membrane	membrane	NOUN
admet-923	253	23	permeation	permeation	NOUN
admet-923	253	24	.	.	PUNCT
admet-923	254	1	therefore	therefore	ADV
admet-923	254	2	,	,	PUNCT
admet-923	254	3	a	a	DET
admet-923	254	4	rough	rough	ADJ
admet-923	254	5	estimation	estimation	NOUN
admet-923	254	6	of	of	ADP
admet-923	254	7	permeability	permeability	NOUN
admet-923	254	8	from	from	ADP
admet-923	254	9	experimental	experimental	ADJ
admet-923	254	10	log	log	NOUN
admet-923	254	11	dph6.5	dph6.5	NUM
admet-923	254	12	will	will	AUX
admet-923	254	13	be	be	AUX
admet-923	254	14	sufficient	sufficient	ADJ
admet-923	254	15	and	and	CCONJ
admet-923	254	16	could	could	AUX
admet-923	254	17	be	be	AUX
admet-923	254	18	more	more	ADV
admet-923	254	19	reliable	reliable	ADJ
admet-923	254	20	[	[	X
admet-923	254	21	55,86	55,86	NOUN
admet-923	254	22	]	]	PUNCT
admet-923	254	23	)	)	PUNCT
admet-923	254	24	.	.	PUNCT
admet-923	255	1	the	the	DET
admet-923	255	2	above	above	ADJ
admet-923	255	3	methods	method	NOUN
admet-923	255	4	showed	show	VERB
admet-923	255	5	similar	similar	ADJ
admet-923	255	6	fa	fa	NOUN
admet-923	255	7	values	value	NOUN
admet-923	255	8	when	when	SCONJ
admet-923	255	9	applied	apply	VERB
admet-923	255	10	to	to	ADP
admet-923	255	11	the	the	DET
admet-923	255	12	same	same	ADJ
admet-923	255	13	drug	drug	NOUN
admet-923	255	14	in	in	ADP
admet-923	255	15	most	most	ADJ
admet-923	255	16	cases	case	NOUN
admet-923	255	17	[	[	X
admet-923	255	18	50,79,82,83	50,79,82,83	NUM
admet-923	255	19	]	]	PUNCT
admet-923	255	20	,	,	PUNCT
admet-923	255	21	confirming	confirm	VERB
admet-923	255	22	the	the	DET
admet-923	255	23	validity	validity	NOUN
admet-923	255	24	of	of	ADP
admet-923	255	25	these	these	DET
admet-923	255	26	methods	method	NOUN
admet-923	255	27	.	.	PUNCT
admet-923	256	1	more	more	ADJ
admet-923	256	2	than	than	ADP
admet-923	256	3	600	600	NUM
admet-923	256	4	clinical	clinical	ADJ
admet-923	256	5	fa	fa	NOUN
admet-923	256	6	data	datum	NOUN
admet-923	256	7	has	have	AUX
admet-923	256	8	been	be	AUX
admet-923	256	9	compiled	compile	VERB
admet-923	256	10	from	from	ADP
admet-923	256	11	the	the	DET
admet-923	256	12	literature	literature	NOUN
admet-923	256	13	and	and	CCONJ
admet-923	256	14	has	have	AUX
admet-923	256	15	been	be	AUX
admet-923	256	16	used	use	VERB
admet-923	256	17	to	to	PART
admet-923	256	18	evaluate	evaluate	VERB
admet-923	256	19	oa	oa	ADP
admet-923	256	20	pbpk	pbpk	NOUN
admet-923	256	21	models	model	NOUN
admet-923	257	1	[	[	X
admet-923	257	2	5,50,73,79,83,86,89,90	5,50,73,79,83,86,89,90	X
admet-923	257	3	]	]	PUNCT
admet-923	257	4	.	.	PUNCT
admet-923	258	1	for	for	ADP
admet-923	258	2	low	low	ADJ
admet-923	258	3	fa	fa	NOUN
admet-923	258	4	drugs	drug	NOUN
admet-923	258	5	the	the	DET
admet-923	258	6	inter	inter	ADJ
admet-923	258	7	-	-	ADJ
admet-923	258	8	subject	subject	ADJ
admet-923	258	9	variability	variability	NOUN
admet-923	258	10	is	be	AUX
admet-923	258	11	usually	usually	ADV
admet-923	258	12	very	very	ADV
admet-923	258	13	high	high	ADJ
admet-923	258	14	,	,	PUNCT
admet-923	258	15	and	and	CCONJ
admet-923	258	16	a	a	DET
admet-923	258	17	clinical	clinical	ADJ
admet-923	258	18	study	study	NOUN
admet-923	258	19	may	may	AUX
admet-923	258	20	be	be	AUX
admet-923	258	21	an	an	DET
admet-923	258	22	unrepresentative	unrepresentative	ADJ
admet-923	258	23	sample	sample	NOUN
admet-923	258	24	of	of	ADP
admet-923	258	25	the	the	DET
admet-923	258	26	population	population	NOUN
admet-923	258	27	.	.	PUNCT
admet-923	259	1	2.7	2.7	X
admet-923	259	2	.	.	PUNCT
admet-923	259	3	often	often	ADV
admet-923	259	4	forgotten	forget	VERB
admet-923	259	5	physicochemical	physicochemical	ADJ
admet-923	259	6	mechanisms	mechanism	NOUN
admet-923	259	7	in	in	ADP
admet-923	259	8	oa	oa	PROPN
admet-923	259	9	pbpk	pbpk	NOUN
admet-923	259	10	modelling	model	VERB
admet-923	259	11	a	a	DET
admet-923	259	12	good	good	ADJ
admet-923	259	13	understanding	understanding	NOUN
admet-923	259	14	of	of	ADP
admet-923	259	15	physicochemical	physicochemical	ADJ
admet-923	259	16	processes	process	NOUN
admet-923	259	17	in	in	ADP
admet-923	259	18	oral	oral	ADJ
admet-923	259	19	drug	drug	NOUN
admet-923	259	20	absorption	absorption	NOUN
admet-923	259	21	is	be	AUX
admet-923	259	22	specifically	specifically	ADV
admet-923	259	23	important	important	ADJ
admet-923	259	24	for	for	SCONJ
admet-923	259	25	oa	oa	ADP
admet-923	259	26	pbpk	pbpk	PROPN
admet-923	259	27	modelling	model	VERB
admet-923	259	28	(	(	PUNCT
admet-923	259	29	see	see	VERB
admet-923	259	30	conclusion	conclusion	NOUN
admet-923	259	31	part	part	NOUN
admet-923	259	32	)	)	PUNCT
admet-923	259	33	.	.	PUNCT
admet-923	260	1	below	below	ADV
admet-923	260	2	are	be	AUX
admet-923	260	3	some	some	DET
admet-923	260	4	examples	example	NOUN
admet-923	260	5	of	of	ADP
admet-923	260	6	physicochemical	physicochemical	ADJ
admet-923	260	7	mechanisms	mechanism	NOUN
admet-923	260	8	that	that	PRON
admet-923	260	9	are	be	AUX
admet-923	260	10	often	often	ADV
admet-923	260	11	forgotten	forget	VERB
admet-923	260	12	in	in	ADP
admet-923	260	13	oa	oa	ADP
admet-923	260	14	pbpk	pbpk	PROPN
admet-923	260	15	modelling	modelling	NOUN
admet-923	260	16	.	.	PUNCT
admet-923	261	1	example	example	NOUN
admet-923	261	2	1	1	NUM
admet-923	261	3	:	:	PUNCT
admet-923	262	1	peff	peff	NOUN
admet-923	262	2	estimation	estimation	NOUN
admet-923	262	3	from	from	ADP
admet-923	262	4	in	in	ADP
admet-923	262	5	vitro	vitro	X
admet-923	262	6	data	datum	NOUN
admet-923	262	7	it	it	PRON
admet-923	262	8	is	be	AUX
admet-923	262	9	well	well	ADV
admet-923	262	10	known	know	VERB
admet-923	262	11	that	that	SCONJ
admet-923	262	12	the	the	DET
admet-923	262	13	effective	effective	ADJ
admet-923	262	14	intestinal	intestinal	ADJ
admet-923	262	15	membrane	membrane	NOUN
admet-923	262	16	permeability	permeability	NOUN
admet-923	262	17	(	(	PUNCT
admet-923	262	18	peff	peff	PROPN
admet-923	262	19	)	)	PUNCT
admet-923	262	20	is	be	AUX
admet-923	262	21	markedly	markedly	ADV
admet-923	262	22	affected	affect	VERB
admet-923	262	23	by	by	ADP
admet-923	262	24	bile	bile	NOUN
admet-923	262	25	micelle	micelle	NOUN
admet-923	262	26	binding	bind	VERB
admet-923	262	27	[	[	X
admet-923	262	28	51,91–94	51,91–94	NOUN
admet-923	262	29	]	]	PUNCT
admet-923	262	30	,	,	PUNCT
admet-923	262	31	the	the	DET
admet-923	262	32	unstirred	unstirred	ADJ
admet-923	262	33	water	water	NOUN
admet-923	262	34	layer	layer	NOUN
admet-923	262	35	(	(	PUNCT
admet-923	262	36	uwl	uwl	X
admet-923	262	37	)	)	PUNCT
admet-923	263	1	[	[	X
admet-923	263	2	74,95–98	74,95–98	NUM
admet-923	263	3	]	]	X
admet-923	263	4	,	,	PUNCT
admet-923	263	5	and	and	CCONJ
admet-923	263	6	the	the	DET
admet-923	263	7	anatomical	anatomical	ADJ
admet-923	263	8	features	feature	NOUN
admet-923	263	9	(	(	PUNCT
admet-923	263	10	villi	villi	NOUN
admet-923	263	11	and	and	CCONJ
admet-923	263	12	fold	fold	ADJ
admet-923	263	13	structures	structure	NOUN
admet-923	263	14	)	)	PUNCT
admet-923	264	1	[	[	X
admet-923	264	2	99	99	NUM
admet-923	264	3	]	]	PUNCT
admet-923	264	4	(	(	PUNCT
admet-923	264	5	section	section	NOUN
admet-923	264	6	2.1	2.1	NUM
admet-923	264	7	)	)	PUNCT
admet-923	264	8	(	(	PUNCT
admet-923	264	9	cf	cf	NOUN
admet-923	264	10	.	.	PUNCT
admet-923	265	1	the	the	DET
admet-923	265	2	peff	peff	NOUN
admet-923	265	3	value	value	NOUN
admet-923	265	4	includes	include	VERB
admet-923	265	5	the	the	DET
admet-923	265	6	free	free	ADJ
admet-923	265	7	fraction	fraction	NOUN
admet-923	265	8	effects	effect	NOUN
admet-923	265	9	by	by	ADP
admet-923	265	10	definition	definition	NOUN
admet-923	265	11	in	in	ADP
admet-923	265	12	most	most	ADJ
admet-923	265	13	cases	case	NOUN
admet-923	265	14	of	of	ADP
admet-923	265	15	commercial	commercial	ADJ
admet-923	265	16	software	software	NOUN
admet-923	265	17	)	)	PUNCT
admet-923	265	18	.	.	PUNCT
admet-923	266	1	however	however	ADV
admet-923	266	2	,	,	PUNCT
admet-923	266	3	these	these	DET
admet-923	266	4	factors	factor	NOUN
admet-923	266	5	can	can	AUX
admet-923	266	6	not	not	PART
admet-923	266	7	be	be	AUX
admet-923	266	8	captured	capture	VERB
admet-923	266	9	by	by	ADP
admet-923	266	10	an	an	DET
admet-923	266	11	empirical	empirical	ADJ
admet-923	266	12	equation	equation	NOUN
admet-923	266	13	of	of	ADP
admet-923	266	14	peff	peff	NOUN
admet-923	266	15	=	=	SYM
admet-923	266	16	apapp	apapp	PROPN
admet-923	266	17	b	b	PROPN
admet-923	266	18	(	(	PUNCT
admet-923	266	19	log	log	NOUN
admet-923	266	20	peff	peff	NOUN
admet-923	266	21	=	=	PUNCT
admet-923	266	22	a	a	PRON
admet-923	266	23	’	'	PUNCT
admet-923	266	24	+	+	ADJ
admet-923	266	25	b’log	b’log	X
admet-923	266	26	papp	papp	NOUN
admet-923	266	27	)	)	PUNCT
admet-923	266	28	(	(	PUNCT
admet-923	266	29	papp	papp	NOUN
admet-923	266	30	:	:	PUNCT
admet-923	266	31	in	in	ADP
admet-923	266	32	vitro	vitro	X
admet-923	266	33	apparent	apparent	ADJ
admet-923	266	34	permeability	permeability	NOUN
admet-923	266	35	)	)	PUNCT
admet-923	266	36	.	.	PUNCT
admet-923	267	1	this	this	DET
admet-923	267	2	empirical	empirical	ADJ
admet-923	267	3	equation	equation	NOUN
admet-923	267	4	can	can	AUX
admet-923	267	5	not	not	PART
admet-923	267	6	correctly	correctly	ADV
admet-923	267	7	explain	explain	VERB
admet-923	267	8	and	and	CCONJ
admet-923	267	9	predict	predict	VERB
admet-923	267	10	the	the	DET
admet-923	267	11	food	food	NOUN
admet-923	267	12	effect	effect	NOUN
admet-923	267	13	(	(	PUNCT
admet-923	267	14	especially	especially	ADV
admet-923	267	15	the	the	DET
admet-923	267	16	negative	negative	ADJ
admet-923	267	17	food	food	NOUN
admet-923	267	18	effect	effect	NOUN
admet-923	267	19	)	)	PUNCT
admet-923	268	1	[	[	X
admet-923	268	2	51,91,100	51,91,100	NUM
admet-923	268	3	]	]	PUNCT
admet-923	268	4	,	,	PUNCT
admet-923	268	5	the	the	DET
admet-923	268	6	formulation	formulation	NOUN
admet-923	268	7	effect	effect	NOUN
admet-923	268	8	(	(	PUNCT
admet-923	268	9	solubility	solubility	NOUN
admet-923	268	10	-	-	PUNCT
admet-923	268	11	permeability	permeability	NOUN
admet-923	268	12	trade	trade	NOUN
admet-923	268	13	-	-	PUNCT
admet-923	268	14	off)[101,102	off)[101,102	PRON
admet-923	268	15	]	]	PUNCT
admet-923	268	16	,	,	PUNCT
admet-923	268	17	and	and	CCONJ
admet-923	268	18	species	specie	NOUN
admet-923	268	19	differences	difference	NOUN
admet-923	268	20	[	[	X
admet-923	268	21	52,103	52,103	NUM
admet-923	268	22	]	]	PUNCT
admet-923	268	23	.	.	PUNCT
admet-923	269	1	the	the	DET
admet-923	269	2	empirical	empirical	ADJ
admet-923	269	3	coefficients	coefficient	NOUN
admet-923	269	4	,	,	PUNCT
admet-923	269	5	a	a	PRON
admet-923	269	6	and	and	CCONJ
admet-923	269	7	b	b	NOUN
admet-923	269	8	(	(	PUNCT
admet-923	269	9	or	or	CCONJ
admet-923	269	10	a	a	PRON
admet-923	269	11	’	'	PUNCT
admet-923	269	12	and	and	CCONJ
admet-923	269	13	b	b	NOUN
admet-923	269	14	’	'	PUNCT
admet-923	269	15	)	)	PUNCT
admet-923	269	16	,	,	PUNCT
admet-923	269	17	are	be	AUX
admet-923	269	18	usually	usually	ADV
admet-923	269	19	determined	determine	VERB
admet-923	269	20	by	by	ADP
admet-923	269	21	the	the	DET
admet-923	269	22	regression	regression	NOUN
admet-923	269	23	analysis	analysis	NOUN
admet-923	269	24	between	between	ADP
admet-923	269	25	peff	peff	PROPN
admet-923	269	26	and	and	CCONJ
admet-923	269	27	papp	papp	NOUN
admet-923	269	28	using	use	VERB
admet-923	269	29	hydrophilic	hydrophilic	ADJ
admet-923	269	30	model	model	NOUN
admet-923	269	31	drugs	drug	NOUN
admet-923	269	32	(	(	PUNCT
admet-923	269	33	log	log	NOUN
admet-923	269	34	d	d	X
admet-923	269	35	<	<	X
admet-923	269	36	1)[31	1)[31	NUM
admet-923	269	37	]	]	PUNCT
admet-923	269	38	.	.	PUNCT
admet-923	270	1	therefore	therefore	ADV
admet-923	270	2	,	,	PUNCT
admet-923	270	3	lipophilic	lipophilic	ADJ
admet-923	270	4	drugs	drug	NOUN
admet-923	270	5	are	be	AUX
admet-923	270	6	beyond	beyond	ADP
admet-923	270	7	the	the	DET
admet-923	270	8	applicable	applicable	ADJ
admet-923	270	9	range	range	NOUN
admet-923	270	10	of	of	ADP
admet-923	270	11	the	the	DET
admet-923	270	12	standard	standard	ADJ
admet-923	270	13	curve	curve	NOUN
admet-923	270	14	.	.	PUNCT
admet-923	271	1	in	in	ADP
admet-923	271	2	addition	addition	NOUN
admet-923	271	3	,	,	PUNCT
admet-923	271	4	papp	papp	NOUN
admet-923	271	5	is	be	AUX
admet-923	271	6	usually	usually	ADV
admet-923	271	7	measured	measure	VERB
admet-923	271	8	in	in	ADP
admet-923	271	9	the	the	DET
admet-923	271	10	absence	absence	NOUN
admet-923	271	11	of	of	ADP
admet-923	271	12	bile	bile	NOUN
admet-923	271	13	micelles	micelle	NOUN
admet-923	271	14	on	on	ADP
admet-923	271	15	the	the	DET
admet-923	271	16	apical	apical	ADJ
admet-923	271	17	side	side	NOUN
admet-923	271	18	and	and	CCONJ
admet-923	271	19	albumin	albumin	NOUN
admet-923	271	20	on	on	ADP
admet-923	271	21	the	the	DET
admet-923	271	22	basolateral	basolateral	ADJ
admet-923	271	23	side	side	NOUN
admet-923	271	24	.	.	PUNCT
admet-923	272	1	the	the	DET
admet-923	272	2	thick	thick	ADJ
admet-923	272	3	uwl	uwl	NOUN
admet-923	272	4	in	in	ADP
admet-923	272	5	the	the	DET
admet-923	272	6	in	in	ADV
admet-923	272	7	vitro	vitro	X
admet-923	272	8	systems	system	NOUN
admet-923	272	9	mask	mask	VERB
admet-923	272	10	the	the	DET
admet-923	272	11	membrane	membrane	NOUN
admet-923	272	12	permeability	permeability	NOUN
admet-923	272	13	when	when	SCONJ
admet-923	272	14	not	not	PART
admet-923	272	15	rigorously	rigorously	ADV
admet-923	272	16	agitated	agitate	VERB
admet-923	272	17	[	[	X
admet-923	272	18	98,104	98,104	X
admet-923	272	19	]	]	PUNCT
admet-923	272	20	.	.	PUNCT
admet-923	273	1	finally	finally	ADV
admet-923	273	2	,	,	PUNCT
admet-923	273	3	and	and	CCONJ
admet-923	273	4	most	most	ADV
admet-923	273	5	importantly	importantly	ADV
admet-923	273	6	,	,	PUNCT
admet-923	273	7	this	this	DET
admet-923	273	8	equation	equation	NOUN
admet-923	273	9	is	be	AUX
admet-923	273	10	an	an	DET
admet-923	273	11	empirical	empirical	ADJ
admet-923	273	12	correlation	correlation	NOUN
admet-923	273	13	so	so	SCONJ
admet-923	273	14	that	that	SCONJ
admet-923	273	15	it	it	PRON
admet-923	273	16	should	should	AUX
admet-923	273	17	not	not	PART
admet-923	273	18	be	be	AUX
admet-923	273	19	referred	refer	VERB
admet-923	273	20	to	to	ADP
admet-923	273	21	as	as	ADP
admet-923	273	22	“	"	PUNCT
admet-923	273	23	physiologically	physiologically	ADV
admet-923	273	24	-	-	PUNCT
admet-923	273	25	based	base	VERB
admet-923	273	26	”	"	PUNCT
admet-923	273	27	.	.	PUNCT
admet-923	274	1	a	a	DET
admet-923	274	2	mechanistic	mechanistic	ADJ
admet-923	274	3	physiologically	physiologically	ADV
admet-923	274	4	-	-	PUNCT
admet-923	274	5	based	base	VERB
admet-923	274	6	permeation	permeation	NOUN
admet-923	274	7	model	model	NOUN
admet-923	274	8	that	that	PRON
admet-923	274	9	considers	consider	VERB
admet-923	274	10	these	these	DET
admet-923	274	11	factors	factor	NOUN
admet-923	274	12	is	be	AUX
admet-923	274	13	available	available	ADJ
admet-923	274	14	in	in	ADP
admet-923	274	15	the	the	DET
admet-923	274	16	literature	literature	NOUN
admet-923	274	17	(	(	PUNCT
admet-923	274	18	section	section	NOUN
admet-923	274	19	2.1	2.1	NUM
admet-923	274	20	)	)	PUNCT
admet-923	275	1	[	[	X
admet-923	275	2	49–55	49–55	X
admet-923	275	3	]	]	PUNCT
admet-923	275	4	and	and	CCONJ
admet-923	275	5	in	in	ADP
admet-923	275	6	some	some	DET
admet-923	275	7	commercial	commercial	ADJ
admet-923	275	8	software	software	NOUN
admet-923	275	9	products	product	NOUN
admet-923	275	10	.	.	PUNCT
admet-923	276	1	example	example	NOUN
admet-923	276	2	2	2	NUM
admet-923	276	3	:	:	PUNCT
admet-923	276	4	dissolution	dissolution	NOUN
admet-923	276	5	in	in	ADP
admet-923	276	6	the	the	DET
admet-923	276	7	stomach	stomach	NOUN
admet-923	276	8	the	the	DET
admet-923	276	9	gastric	gastric	ADJ
admet-923	276	10	fluid	fluid	NOUN
admet-923	276	11	is	be	AUX
admet-923	276	12	acidified	acidify	VERB
admet-923	276	13	by	by	ADP
admet-923	276	14	hydrochloric	hydrochloric	ADJ
admet-923	276	15	acid	acid	NOUN
admet-923	276	16	(	(	PUNCT
admet-923	276	17	hcl	hcl	PROPN
admet-923	276	18	)	)	PUNCT
admet-923	276	19	.	.	PUNCT
admet-923	277	1	because	because	SCONJ
admet-923	277	2	hcl	hcl	PROPN
admet-923	277	3	is	be	AUX
admet-923	277	4	not	not	PART
admet-923	277	5	an	an	DET
admet-923	277	6	efficient	efficient	ADJ
admet-923	277	7	buffer	buffer	NOUN
admet-923	277	8	,	,	PUNCT
admet-923	277	9	the	the	DET
admet-923	277	10	ph	ph	ADJ
admet-923	277	11	value	value	NOUN
admet-923	277	12	of	of	ADP
admet-923	277	13	the	the	DET
admet-923	277	14	gastric	gastric	ADJ
admet-923	277	15	fluid	fluid	NOUN
admet-923	277	16	increases	increase	NOUN
admet-923	277	17	when	when	SCONJ
admet-923	277	18	a	a	DET
admet-923	277	19	free	free	ADJ
admet-923	277	20	weak	weak	ADJ
admet-923	277	21	base	base	NOUN
admet-923	277	22	drug	drug	NOUN
admet-923	277	23	is	be	AUX
admet-923	277	24	dissolved	dissolve	VERB
admet-923	277	25	[	[	X
admet-923	277	26	105	105	NUM
admet-923	277	27	]	]	PUNCT
admet-923	277	28	.	.	PUNCT
admet-923	278	1	in	in	ADP
admet-923	278	2	addition	addition	NOUN
admet-923	278	3	,	,	PUNCT
admet-923	278	4	the	the	DET
admet-923	278	5	solid	solid	ADJ
admet-923	278	6	surface	surface	NOUN
admet-923	278	7	ph	ph	NOUN
admet-923	278	8	is	be	AUX
admet-923	278	9	markedly	markedly	ADV
admet-923	278	10	increased	increase	VERB
admet-923	278	11	by	by	ADP
admet-923	278	12	the	the	DET
admet-923	278	13	dissolving	dissolve	VERB
admet-923	278	14	free	free	ADJ
admet-923	278	15	base	base	NOUN
admet-923	278	16	molecules	molecule	NOUN
admet-923	278	17	[	[	X
admet-923	278	18	42,43,48,61,106,107	42,43,48,61,106,107	X
admet-923	278	19	]	]	PUNCT
admet-923	278	20	.	.	PUNCT
admet-923	279	1	therefore	therefore	ADV
admet-923	279	2	,	,	PUNCT
admet-923	279	3	the	the	DET
admet-923	279	4	solid	solid	ADJ
admet-923	279	5	surface	surface	NOUN
admet-923	279	6	solubility	solubility	NOUN
admet-923	279	7	(	(	PUNCT
admet-923	279	8	ssurface	ssurface	NOUN
admet-923	279	9	)	)	PUNCT
admet-923	279	10	and	and	CCONJ
admet-923	279	11	the	the	DET
admet-923	279	12	bulk	bulk	ADJ
admet-923	279	13	phase	phase	NOUN
admet-923	279	14	solubility	solubility	NOUN
admet-923	279	15	(	(	PUNCT
admet-923	279	16	sdissolv	sdissolv	ADJ
admet-923	279	17	)	)	PUNCT
admet-923	279	18	must	must	AUX
admet-923	279	19	be	be	AUX
admet-923	279	20	differentiated	differentiate	VERB
admet-923	279	21	in	in	ADP
admet-923	279	22	the	the	DET
admet-923	279	23	admet	admet	PROPN
admet-923	279	24	&	&	CCONJ
admet-923	279	25	dmpk	dmpk	PROPN
admet-923	279	26	9(2	9(2	NUM
admet-923	279	27	)	)	PUNCT
admet-923	279	28	(	(	PUNCT
admet-923	279	29	2021	2021	NUM
admet-923	279	30	)	)	PUNCT
admet-923	279	31	75	75	NUM
admet-923	279	32	-	-	SYM
admet-923	279	33	109	109	NUM
admet-923	279	34	lost	lose	VERB
admet-923	279	35	in	in	ADP
admet-923	279	36	modelling	modelling	NOUN
admet-923	279	37	and	and	CCONJ
admet-923	279	38	simulation	simulation	NOUN
admet-923	279	39	?	?	PUNCT
admet-923	280	1	doi	doi	NOUN
admet-923	280	2	:	:	PUNCT
admet-923	280	3	https:/doi.org/10.5599	https:/doi.org/10.5599	PROPN
admet-923	280	4	/	/	SYM
admet-923	280	5	admet.923	admet.923	PROPN
admet-923	280	6	85	85	NUM
admet-923	280	7	nernst	nernst	PROPN
admet-923	280	8	-	-	PUNCT
admet-923	280	9	noyes	noyes	PROPN
admet-923	280	10	-	-	PUNCT
admet-923	280	11	whitney	whitney	PROPN
admet-923	280	12	equation	equation	NOUN
admet-923	280	13	(	(	PUNCT
admet-923	280	14	section	section	NOUN
admet-923	280	15	2.1	2.1	NUM
admet-923	280	16	)	)	PUNCT
admet-923	281	1	[	[	X
admet-923	281	2	35	35	NUM
admet-923	281	3	]	]	PUNCT
admet-923	281	4	.	.	PUNCT
admet-923	282	1	these	these	DET
admet-923	282	2	two	two	NUM
admet-923	282	3	factors	factor	NOUN
admet-923	282	4	are	be	AUX
admet-923	282	5	important	important	ADJ
admet-923	282	6	for	for	ADP
admet-923	282	7	predicting	predict	VERB
admet-923	282	8	the	the	DET
admet-923	282	9	effect	effect	NOUN
admet-923	282	10	of	of	ADP
admet-923	282	11	gastric	gastric	ADJ
admet-923	282	12	ph	ph	NOUN
admet-923	282	13	on	on	ADP
admet-923	282	14	drug	drug	NOUN
admet-923	282	15	absorption	absorption	NOUN
admet-923	282	16	.	.	PUNCT
admet-923	283	1	a	a	DET
admet-923	283	2	mechanistic	mechanistic	ADJ
admet-923	283	3	dissolution	dissolution	NOUN
admet-923	283	4	model	model	NOUN
admet-923	283	5	that	that	PRON
admet-923	283	6	considers	consider	VERB
admet-923	283	7	these	these	DET
admet-923	283	8	factors	factor	NOUN
admet-923	283	9	is	be	AUX
admet-923	283	10	also	also	ADV
admet-923	283	11	available	available	ADJ
admet-923	283	12	in	in	ADP
admet-923	283	13	the	the	DET
admet-923	283	14	literature	literature	NOUN
admet-923	283	15	(	(	PUNCT
admet-923	283	16	section	section	NOUN
admet-923	283	17	2.1	2.1	NUM
admet-923	283	18	)	)	PUNCT
admet-923	284	1	[	[	X
admet-923	284	2	42,43,48,61,79,106,107	42,43,48,61,79,106,107	NOUN
admet-923	284	3	]	]	PUNCT
admet-923	284	4	and	and	CCONJ
admet-923	284	5	in	in	ADP
admet-923	284	6	some	some	DET
admet-923	284	7	commercial	commercial	ADJ
admet-923	284	8	software	software	NOUN
admet-923	284	9	products	product	NOUN
admet-923	284	10	.	.	PUNCT
admet-923	285	1	example	example	NOUN
admet-923	286	1	3	3	NUM
admet-923	286	2	:	:	PUNCT
admet-923	286	3	salt	salt	NOUN
admet-923	286	4	dissolution	dissolution	NOUN
admet-923	286	5	the	the	DET
admet-923	286	6	dissolution	dissolution	NOUN
admet-923	286	7	modelling	modelling	NOUN
admet-923	286	8	of	of	ADP
admet-923	286	9	a	a	DET
admet-923	286	10	salt	salt	NOUN
admet-923	286	11	form	form	NOUN
admet-923	286	12	drug	drug	NOUN
admet-923	286	13	is	be	AUX
admet-923	286	14	not	not	PART
admet-923	286	15	that	that	ADV
admet-923	286	16	easy	easy	ADJ
admet-923	286	17	as	as	SCONJ
admet-923	286	18	one	one	PRON
admet-923	286	19	might	might	AUX
admet-923	286	20	imagine	imagine	VERB
admet-923	286	21	.	.	PUNCT
admet-923	287	1	the	the	DET
admet-923	287	2	solid	solid	ADJ
admet-923	287	3	surface	surface	NOUN
admet-923	287	4	solubility	solubility	NOUN
admet-923	287	5	of	of	ADP
admet-923	287	6	a	a	DET
admet-923	287	7	salt	salt	NOUN
admet-923	287	8	is	be	AUX
admet-923	287	9	significantly	significantly	ADV
admet-923	287	10	higher	high	ADJ
admet-923	287	11	than	than	ADP
admet-923	287	12	that	that	PRON
admet-923	287	13	of	of	ADP
admet-923	287	14	the	the	DET
admet-923	287	15	free	free	ADJ
admet-923	287	16	form	form	NOUN
admet-923	287	17	(	(	PUNCT
admet-923	287	18	>	>	X
admet-923	287	19	100	100	NUM
admet-923	287	20	-	-	ADJ
admet-923	287	21	fold	fold	VERB
admet-923	287	22	in	in	ADV
admet-923	287	23	most	most	ADJ
admet-923	287	24	cases	case	NOUN
admet-923	287	25	)	)	PUNCT
admet-923	287	26	.	.	PUNCT
admet-923	288	1	however	however	ADV
admet-923	288	2	,	,	PUNCT
admet-923	288	3	the	the	DET
admet-923	288	4	equilibrium	equilibrium	NOUN
admet-923	288	5	solubility	solubility	NOUN
admet-923	288	6	in	in	ADP
admet-923	288	7	the	the	DET
admet-923	288	8	ph	ph	VERB
admet-923	288	9	-	-	PUNCT
admet-923	288	10	controlled	control	VERB
admet-923	288	11	region	region	NOUN
admet-923	288	12	becomes	become	VERB
admet-923	288	13	the	the	DET
admet-923	288	14	same	same	ADJ
admet-923	288	15	regardless	regardless	ADV
admet-923	288	16	of	of	ADP
admet-923	288	17	the	the	DET
admet-923	288	18	starting	starting	NOUN
admet-923	288	19	material	material	NOUN
admet-923	288	20	is	be	AUX
admet-923	288	21	a	a	DET
admet-923	288	22	free	free	ADJ
admet-923	288	23	form	form	NOUN
admet-923	288	24	or	or	CCONJ
admet-923	288	25	a	a	DET
admet-923	288	26	salt	salt	NOUN
admet-923	288	27	form	form	NOUN
admet-923	288	28	(	(	PUNCT
admet-923	288	29	unless	unless	SCONJ
admet-923	288	30	the	the	DET
admet-923	288	31	residual	residual	ADJ
admet-923	288	32	solid	solid	ADJ
admet-923	288	33	(	(	PUNCT
admet-923	288	34	equilibrium	equilibrium	NOUN
admet-923	288	35	maker	maker	NOUN
admet-923	288	36	)	)	PUNCT
admet-923	288	37	show	show	VERB
admet-923	288	38	different	different	ADJ
admet-923	288	39	solid	solid	ADJ
admet-923	288	40	forms	form	NOUN
admet-923	288	41	)	)	PUNCT
admet-923	288	42	(	(	PUNCT
admet-923	288	43	cf	cf	NOUN
admet-923	288	44	.	.	PUNCT
admet-923	289	1	a	a	DET
admet-923	289	2	salt	salt	NOUN
admet-923	289	3	form	form	NOUN
admet-923	289	4	coverts	covert	NOUN
admet-923	289	5	to	to	ADP
admet-923	289	6	a	a	DET
admet-923	289	7	free	free	ADJ
admet-923	289	8	form	form	NOUN
admet-923	289	9	in	in	ADP
admet-923	289	10	the	the	DET
admet-923	289	11	ph	ph	VERB
admet-923	289	12	-	-	PUNCT
admet-923	289	13	controlled	control	VERB
admet-923	289	14	region	region	NOUN
admet-923	289	15	)	)	PUNCT
admet-923	289	16	.	.	PUNCT
admet-923	290	1	in	in	ADP
admet-923	290	2	drug	drug	NOUN
admet-923	290	3	discovery	discovery	NOUN
admet-923	290	4	and	and	CCONJ
admet-923	290	5	development	development	NOUN
admet-923	290	6	,	,	PUNCT
admet-923	290	7	the	the	DET
admet-923	290	8	solubility	solubility	NOUN
admet-923	290	9	of	of	ADP
admet-923	290	10	a	a	DET
admet-923	290	11	drug	drug	NOUN
admet-923	290	12	substance	substance	NOUN
admet-923	290	13	is	be	AUX
admet-923	290	14	usually	usually	ADV
admet-923	290	15	measured	measure	VERB
admet-923	290	16	in	in	ADP
admet-923	290	17	well	well	ADV
admet-923	290	18	-	-	PUNCT
admet-923	290	19	buffered	buffer	VERB
admet-923	290	20	media	medium	NOUN
admet-923	290	21	after	after	ADP
admet-923	290	22	a	a	DET
admet-923	290	23	sufficient	sufficient	ADJ
admet-923	290	24	incubation	incubation	NOUN
admet-923	290	25	time	time	NOUN
admet-923	290	26	to	to	PART
admet-923	290	27	achieve	achieve	VERB
admet-923	290	28	equilibrium	equilibrium	NOUN
admet-923	290	29	[	[	X
admet-923	290	30	108–111	108–111	NUM
admet-923	290	31	]	]	PUNCT
admet-923	290	32	.	.	PUNCT
admet-923	291	1	the	the	DET
admet-923	291	2	small	small	ADJ
admet-923	291	3	intestinal	intestinal	ADJ
admet-923	291	4	ph	ph	NOUN
admet-923	291	5	(	(	PUNCT
admet-923	291	6	about	about	ADV
admet-923	291	7	ph	ph	ADJ
admet-923	291	8	6.5	6.5	NUM
admet-923	291	9	)	)	PUNCT
admet-923	291	10	is	be	AUX
admet-923	291	11	in	in	ADP
admet-923	291	12	the	the	DET
admet-923	291	13	ph	ph	VERB
admet-923	291	14	-	-	PUNCT
admet-923	291	15	controlled	control	VERB
admet-923	291	16	region	region	NOUN
admet-923	291	17	in	in	ADP
admet-923	291	18	most	most	ADJ
admet-923	291	19	cases	case	NOUN
admet-923	291	20	.	.	PUNCT
admet-923	292	1	in	in	ADP
admet-923	292	2	addition	addition	NOUN
admet-923	292	3	,	,	PUNCT
admet-923	292	4	a	a	DET
admet-923	292	5	salt	salt	NOUN
admet-923	292	6	form	form	NOUN
admet-923	292	7	may	may	AUX
admet-923	292	8	or	or	CCONJ
admet-923	292	9	may	may	AUX
admet-923	292	10	not	not	PART
admet-923	292	11	show	show	VERB
admet-923	292	12	faster	fast	ADJ
admet-923	292	13	dissolution	dissolution	NOUN
admet-923	292	14	and	and	CCONJ
admet-923	292	15	more	more	ADV
admet-923	292	16	importantly	importantly	ADV
admet-923	292	17	supersaturation	supersaturation	NOUN
admet-923	292	18	after	after	ADP
admet-923	292	19	dissolution	dissolution	NOUN
admet-923	292	20	,	,	PUNCT
admet-923	292	21	because	because	SCONJ
admet-923	292	22	the	the	DET
admet-923	292	23	solid	solid	ADJ
admet-923	292	24	surface	surface	NOUN
admet-923	292	25	precipitation	precipitation	NOUN
admet-923	292	26	of	of	ADP
admet-923	292	27	a	a	DET
admet-923	292	28	less	less	ADV
admet-923	292	29	soluble	soluble	ADJ
admet-923	292	30	free	free	ADJ
admet-923	292	31	form	form	NOUN
admet-923	292	32	can	can	AUX
admet-923	292	33	inhibit	inhibit	VERB
admet-923	292	34	the	the	DET
admet-923	292	35	dissolution	dissolution	NOUN
admet-923	292	36	of	of	ADP
admet-923	292	37	its	its	PRON
admet-923	292	38	salt	salt	NOUN
admet-923	292	39	[	[	X
admet-923	292	40	112,113	112,113	NUM
admet-923	292	41	]	]	PUNCT
admet-923	292	42	.	.	PUNCT
admet-923	293	1	the	the	DET
admet-923	293	2	mechanism	mechanism	NOUN
admet-923	293	3	of	of	ADP
admet-923	293	4	supersaturation	supersaturation	NOUN
admet-923	293	5	and	and	CCONJ
admet-923	293	6	precipitation	precipitation	NOUN
admet-923	293	7	is	be	AUX
admet-923	293	8	not	not	PART
admet-923	293	9	well	well	ADV
admet-923	293	10	understood	understand	VERB
admet-923	293	11	at	at	ADP
admet-923	293	12	this	this	DET
admet-923	293	13	moment	moment	NOUN
admet-923	293	14	.	.	PUNCT
admet-923	294	1	however	however	ADV
admet-923	294	2	,	,	PUNCT
admet-923	294	3	at	at	ADP
admet-923	294	4	least	least	ADJ
admet-923	294	5	,	,	PUNCT
admet-923	294	6	it	it	PRON
admet-923	294	7	does	do	AUX
admet-923	294	8	not	not	PART
admet-923	294	9	simply	simply	ADV
admet-923	294	10	follow	follow	VERB
admet-923	294	11	the	the	DET
admet-923	294	12	first	first	ADJ
admet-923	294	13	-	-	PUNCT
admet-923	294	14	order	order	NOUN
admet-923	294	15	kinetics	kinetic	NOUN
admet-923	295	1	[	[	X
admet-923	295	2	114–119	114–119	NUM
admet-923	295	3	]	]	PUNCT
admet-923	295	4	.	.	PUNCT
admet-923	296	1	in	in	ADP
admet-923	296	2	addition	addition	NOUN
admet-923	296	3	,	,	PUNCT
admet-923	296	4	in	in	ADP
admet-923	296	5	silico	silico	NOUN
admet-923	296	6	models	model	NOUN
admet-923	296	7	for	for	ADP
admet-923	296	8	the	the	DET
admet-923	296	9	physicochemical	physicochemical	ADJ
admet-923	296	10	properties	property	NOUN
admet-923	296	11	of	of	ADP
admet-923	296	12	a	a	DET
admet-923	296	13	drug	drug	NOUN
admet-923	296	14	are	be	AUX
admet-923	296	15	not	not	PART
admet-923	296	16	so	so	ADV
admet-923	296	17	accurate	accurate	ADJ
admet-923	296	18	as	as	SCONJ
admet-923	296	19	to	to	PART
admet-923	296	20	be	be	AUX
admet-923	296	21	used	use	VERB
admet-923	296	22	for	for	ADP
admet-923	296	23	pbpk	pbpk	NOUN
admet-923	296	24	modelling	model	VERB
admet-923	296	25	[	[	X
admet-923	296	26	120	120	NUM
admet-923	296	27	]	]	PUNCT
admet-923	296	28	.	.	PUNCT
admet-923	297	1	solubility	solubility	NOUN
admet-923	297	2	measurements	measurement	NOUN
admet-923	297	3	are	be	AUX
admet-923	297	4	not	not	PART
admet-923	297	5	as	as	ADV
admet-923	297	6	easy	easy	ADJ
admet-923	297	7	as	as	SCONJ
admet-923	297	8	a	a	DET
admet-923	297	9	modeler	modeler	NOUN
admet-923	297	10	might	might	AUX
admet-923	297	11	imagine	imagine	VERB
admet-923	297	12	[	[	X
admet-923	297	13	109,111,121	109,111,121	NUM
admet-923	297	14	]	]	PUNCT
admet-923	297	15	.	.	PUNCT
admet-923	298	1	the	the	DET
admet-923	298	2	pka	pka	PROPN
admet-923	298	3	values	value	NOUN
admet-923	298	4	change	change	VERB
admet-923	298	5	between	between	ADP
admet-923	298	6	25	25	NUM
admet-923	298	7	°	°	NOUN
admet-923	298	8	c	c	NOUN
admet-923	298	9	and	and	CCONJ
admet-923	298	10	37	37	NUM
admet-923	298	11	°	°	NOUN
admet-923	298	12	c	c	NOUN
admet-923	299	1	[	[	X
admet-923	299	2	122,123	122,123	NUM
admet-923	299	3	]	]	PUNCT
admet-923	299	4	.	.	PUNCT
admet-923	300	1	enabling	enable	VERB
admet-923	300	2	formulations	formulation	NOUN
admet-923	300	3	such	such	ADJ
admet-923	300	4	as	as	ADP
admet-923	300	5	amorphous	amorphous	ADJ
admet-923	300	6	solid	solid	ADJ
admet-923	300	7	dispersion	dispersion	NOUN
admet-923	300	8	[	[	X
admet-923	300	9	124	124	NUM
admet-923	300	10	]	]	X
admet-923	300	11	,	,	PUNCT
admet-923	300	12	co	co	NOUN
admet-923	300	13	-	-	NOUN
admet-923	300	14	crystal	crystal	NOUN
admet-923	300	15	[	[	X
admet-923	300	16	125,126	125,126	NUM
admet-923	300	17	]	]	PUNCT
admet-923	300	18	,	,	PUNCT
admet-923	300	19	nanoparticles	nanoparticle	VERB
admet-923	300	20	[	[	X
admet-923	300	21	127–129	127–129	NUM
admet-923	300	22	]	]	PUNCT
admet-923	300	23	,	,	PUNCT
admet-923	300	24	and	and	CCONJ
admet-923	300	25	self	self	NOUN
admet-923	300	26	-	-	PUNCT
admet-923	300	27	emulsifying	emulsify	VERB
admet-923	300	28	drug	drug	NOUN
admet-923	300	29	delivery	delivery	NOUN
admet-923	300	30	system	system	NOUN
admet-923	300	31	[	[	X
admet-923	300	32	130,131	130,131	NUM
admet-923	300	33	]	]	PUNCT
admet-923	300	34	also	also	ADV
admet-923	300	35	requires	require	VERB
admet-923	300	36	an	an	DET
admet-923	300	37	in	in	ADP
admet-923	300	38	-	-	PUNCT
admet-923	300	39	depth	depth	NOUN
admet-923	300	40	understanding	understanding	NOUN
admet-923	300	41	of	of	ADP
admet-923	300	42	physical	physical	ADJ
admet-923	300	43	chemistry	chemistry	NOUN
admet-923	300	44	for	for	ADP
admet-923	300	45	oa	oa	PROPN
admet-923	300	46	pbpk	pbpk	NOUN
admet-923	300	47	modelling	modelling	NOUN
admet-923	300	48	.	.	PUNCT
admet-923	301	1	further	further	ADJ
admet-923	301	2	investigations	investigation	NOUN
admet-923	301	3	on	on	ADP
admet-923	301	4	these	these	DET
admet-923	301	5	points	point	NOUN
admet-923	301	6	are	be	AUX
admet-923	301	7	required	require	VERB
admet-923	301	8	in	in	ADP
admet-923	301	9	the	the	DET
admet-923	301	10	future	future	NOUN
admet-923	301	11	(	(	PUNCT
admet-923	301	12	see	see	VERB
admet-923	301	13	conclusion	conclusion	NOUN
admet-923	301	14	part	part	NOUN
admet-923	301	15	)	)	PUNCT
admet-923	301	16	.	.	PUNCT
admet-923	302	1	2.8	2.8	NUM
admet-923	302	2	.	.	PUNCT
admet-923	303	1	a	a	DET
admet-923	303	2	simple	simple	ADJ
admet-923	303	3	pbpk	pbpk	ADJ
admet-923	303	4	model	model	NOUN
admet-923	303	5	or	or	CCONJ
admet-923	303	6	a	a	DET
admet-923	303	7	complex	complex	ADJ
admet-923	303	8	pbpk	pbpk	ADJ
admet-923	303	9	model	model	NOUN
admet-923	303	10	,	,	PUNCT
admet-923	303	11	which	which	PRON
admet-923	303	12	one	one	NOUN
admet-923	303	13	to	to	PART
admet-923	303	14	use	use	VERB
admet-923	303	15	?	?	PUNCT
admet-923	304	1	“	"	PUNCT
admet-923	304	2	everything	everything	PRON
admet-923	304	3	should	should	AUX
admet-923	304	4	be	be	AUX
admet-923	304	5	made	make	VERB
admet-923	304	6	as	as	ADV
admet-923	304	7	simple	simple	ADJ
admet-923	304	8	as	as	ADP
admet-923	304	9	possible	possible	ADJ
admet-923	304	10	,	,	PUNCT
admet-923	304	11	but	but	CCONJ
admet-923	304	12	not	not	PART
admet-923	304	13	simpler	simple	ADJ
admet-923	304	14	.	.	PUNCT
admet-923	304	15	”	"	PUNCT
admet-923	305	1	albert	albert	PROPN
admet-923	305	2	einstein	einstein	PROPN
admet-923	305	3	as	as	SCONJ
admet-923	305	4	mentioned	mention	VERB
admet-923	305	5	above	above	ADV
admet-923	305	6	,	,	PUNCT
admet-923	305	7	we	we	PRON
admet-923	305	8	are	be	AUX
admet-923	305	9	fully	fully	ADV
admet-923	305	10	aware	aware	ADJ
admet-923	305	11	that	that	SCONJ
admet-923	305	12	there	there	PRON
admet-923	305	13	are	be	VERB
admet-923	305	14	various	various	ADJ
admet-923	305	15	opinions	opinion	NOUN
admet-923	305	16	among	among	ADP
admet-923	305	17	the	the	DET
admet-923	305	18	modelers	modeler	NOUN
admet-923	305	19	on	on	ADP
admet-923	305	20	the	the	DET
admet-923	305	21	selection	selection	NOUN
admet-923	305	22	of	of	ADP
admet-923	305	23	mathematical	mathematical	ADJ
admet-923	305	24	models	model	NOUN
admet-923	305	25	.	.	PUNCT
admet-923	306	1	a	a	DET
admet-923	306	2	pbpk	pbpk	ADJ
admet-923	306	3	model	model	NOUN
admet-923	306	4	should	should	AUX
admet-923	306	5	be	be	AUX
admet-923	306	6	selected	select	VERB
admet-923	306	7	considering	consider	VERB
admet-923	306	8	the	the	DET
admet-923	306	9	purpose	purpose	NOUN
admet-923	306	10	of	of	ADP
admet-923	306	11	modelling	modelling	NOUN
admet-923	306	12	and	and	CCONJ
admet-923	306	13	available	available	ADJ
admet-923	306	14	data	datum	NOUN
admet-923	306	15	at	at	ADP
admet-923	306	16	each	each	DET
admet-923	306	17	drug	drug	NOUN
admet-923	306	18	discovery	discovery	NOUN
admet-923	306	19	and	and	CCONJ
admet-923	306	20	development	development	NOUN
admet-923	306	21	stage	stage	NOUN
admet-923	306	22	.	.	PUNCT
admet-923	307	1	in	in	ADP
admet-923	307	2	the	the	DET
admet-923	307	3	early	early	ADJ
admet-923	307	4	drug	drug	NOUN
admet-923	307	5	discovery	discovery	NOUN
admet-923	307	6	stages	stage	NOUN
admet-923	307	7	,	,	PUNCT
admet-923	307	8	a	a	DET
admet-923	307	9	simple	simple	ADJ
admet-923	307	10	pbpk	pbpk	ADJ
admet-923	307	11	model	model	NOUN
admet-923	307	12	may	may	AUX
admet-923	307	13	be	be	AUX
admet-923	307	14	sufficient	sufficient	ADJ
admet-923	307	15	.	.	PUNCT
admet-923	308	1	in	in	ADP
admet-923	308	2	the	the	DET
admet-923	308	3	late	late	ADJ
admet-923	308	4	drug	drug	NOUN
admet-923	308	5	development	development	NOUN
admet-923	308	6	stages	stage	NOUN
admet-923	308	7	and	and	CCONJ
admet-923	308	8	after	after	ADP
admet-923	308	9	launch	launch	NOUN
admet-923	308	10	,	,	PUNCT
admet-923	308	11	a	a	DET
admet-923	308	12	complex	complex	ADJ
admet-923	308	13	pbpk	pbpk	NOUN
admet-923	308	14	model	model	NOUN
admet-923	308	15	may	may	AUX
admet-923	308	16	be	be	AUX
admet-923	308	17	required	require	VERB
admet-923	308	18	to	to	PART
admet-923	308	19	investigate	investigate	VERB
admet-923	308	20	more	more	ADJ
admet-923	308	21	complex	complex	ADJ
admet-923	308	22	clinical	clinical	ADJ
admet-923	308	23	situations	situation	NOUN
admet-923	308	24	.	.	PUNCT
admet-923	309	1	for	for	ADP
admet-923	309	2	the	the	DET
admet-923	309	3	use	use	NOUN
admet-923	309	4	in	in	ADP
admet-923	309	5	the	the	DET
admet-923	309	6	early	early	ADJ
admet-923	309	7	drug	drug	NOUN
admet-923	309	8	discovery	discovery	NOUN
admet-923	309	9	stages	stage	NOUN
admet-923	309	10	,	,	PUNCT
admet-923	309	11	simple	simple	ADJ
admet-923	309	12	models	model	NOUN
admet-923	309	13	can	can	AUX
admet-923	309	14	show	show	VERB
admet-923	309	15	sufficient	sufficient	ADJ
admet-923	309	16	prediction	prediction	NOUN
admet-923	309	17	performance	performance	NOUN
admet-923	309	18	[	[	X
admet-923	309	19	20,64,82,132,133	20,64,82,132,133	NUM
admet-923	309	20	]	]	X
admet-923	309	21	.	.	PUNCT
admet-923	310	1	a	a	DET
admet-923	310	2	simple	simple	ADJ
admet-923	310	3	oa	oa	PROPN
admet-923	310	4	pbpk	pbpk	NOUN
admet-923	310	5	model	model	NOUN
admet-923	310	6	has	have	AUX
admet-923	310	7	shown	show	VERB
admet-923	310	8	good	good	ADJ
admet-923	310	9	prediction	prediction	NOUN
admet-923	310	10	performance	performance	NOUN
admet-923	310	11	for	for	ADP
admet-923	310	12	the	the	DET
admet-923	310	13	fraction	fraction	NOUN
admet-923	310	14	of	of	ADP
admet-923	310	15	a	a	DET
admet-923	310	16	dose	dose	NOUN
admet-923	310	17	absorbed	absorb	VERB
admet-923	310	18	(	(	PUNCT
admet-923	310	19	fa	fa	NOUN
admet-923	310	20	)	)	PUNCT
admet-923	311	1	[	[	X
admet-923	311	2	5,50,79,83,134	5,50,79,83,134	NUM
admet-923	311	3	]	]	PUNCT
admet-923	311	4	and	and	CCONJ
admet-923	311	5	plasma	plasma	NOUN
admet-923	311	6	concentration	concentration	NOUN
admet-923	311	7	(	(	PUNCT
admet-923	311	8	cp	cp	NOUN
admet-923	311	9	)	)	PUNCT
admet-923	311	10	time	time	NOUN
admet-923	311	11	profiles	profile	NOUN
admet-923	311	12	[	[	X
admet-923	311	13	135–143	135–143	NUM
admet-923	311	14	]	]	PUNCT
admet-923	311	15	.	.	PUNCT
admet-923	312	1	for	for	ADP
admet-923	312	2	relative	relative	ADJ
admet-923	312	3	bioavailability	bioavailability	NOUN
admet-923	312	4	(	(	PUNCT
admet-923	312	5	frel	frel	NOUN
admet-923	312	6	)	)	PUNCT
admet-923	312	7	prediction	prediction	NOUN
admet-923	312	8	,	,	PUNCT
admet-923	312	9	a	a	DET
admet-923	312	10	simple	simple	ADJ
admet-923	312	11	oa	oa	ADJ
admet-923	312	12	-	-	PUNCT
admet-923	312	13	pbpk	pbpk	ADJ
admet-923	312	14	model	model	NOUN
admet-923	312	15	is	be	AUX
admet-923	312	16	also	also	ADV
admet-923	312	17	available	available	ADJ
admet-923	312	18	for	for	ADP
admet-923	312	19	the	the	DET
admet-923	312	20	food	food	NOUN
admet-923	312	21	effect	effect	NOUN
admet-923	312	22	(	(	PUNCT
admet-923	312	23	via	via	ADP
admet-923	312	24	bile	bile	NOUN
admet-923	312	25	micelles	micelle	NOUN
admet-923	312	26	)	)	PUNCT
admet-923	312	27	and	and	CCONJ
admet-923	312	28	gastric	gastric	ADJ
admet-923	312	29	acid	acid	NOUN
admet-923	312	30	effect	effect	NOUN
admet-923	312	31	predictions	prediction	NOUN
admet-923	312	32	[	[	X
admet-923	312	33	51,79,100	51,79,100	NUM
admet-923	312	34	]	]	PUNCT
admet-923	312	35	.	.	PUNCT
admet-923	313	1	by	by	ADP
admet-923	313	2	multiplying	multiply	VERB
admet-923	313	3	auc	auc	NOUN
admet-923	313	4	in	in	ADP
admet-923	313	5	the	the	DET
admet-923	313	6	fasted	fasted	ADJ
admet-923	313	7	state	state	NOUN
admet-923	313	8	(	(	PUNCT
admet-923	313	9	or	or	CCONJ
admet-923	313	10	low	low	ADJ
admet-923	313	11	gastric	gastric	ADJ
admet-923	313	12	ph	ph	NOUN
admet-923	313	13	)	)	PUNCT
admet-923	313	14	with	with	ADP
admet-923	313	15	frel	frel	NOUN
admet-923	313	16	(	(	PUNCT
admet-923	313	17	i.e.	i.e.	X
admet-923	313	18	,	,	PUNCT
admet-923	313	19	auc	auc	ADJ
admet-923	313	20	ratio	ratio	NOUN
admet-923	313	21	)	)	PUNCT
admet-923	313	22	,	,	PUNCT
admet-923	313	23	auc	auc	VERB
admet-923	313	24	in	in	ADP
admet-923	313	25	the	the	DET
admet-923	313	26	fed	fed	PROPN
admet-923	313	27	state	state	NOUN
admet-923	313	28	(	(	PUNCT
admet-923	313	29	or	or	CCONJ
admet-923	313	30	high	high	ADJ
admet-923	313	31	gastric	gastric	ADJ
admet-923	313	32	ph	ph	NOUN
admet-923	313	33	)	)	PUNCT
admet-923	313	34	can	can	AUX
admet-923	313	35	be	be	AUX
admet-923	313	36	estimated	estimate	VERB
admet-923	313	37	.	.	PUNCT
admet-923	314	1	minimal	minimal	ADJ
admet-923	314	2	pbpk	pbpk	ADJ
admet-923	314	3	models	model	NOUN
admet-923	314	4	have	have	AUX
admet-923	314	5	also	also	ADV
admet-923	314	6	been	be	AUX
admet-923	314	7	proposed	propose	VERB
admet-923	314	8	to	to	PART
admet-923	314	9	reduce	reduce	VERB
admet-923	314	10	the	the	DET
admet-923	314	11	complexity	complexity	NOUN
admet-923	314	12	of	of	ADP
admet-923	314	13	a	a	DET
admet-923	314	14	model	model	NOUN
admet-923	314	15	(	(	PUNCT
admet-923	314	16	see	see	VERB
admet-923	314	17	section	section	NOUN
admet-923	314	18	3.13	3.13	NUM
admet-923	314	19	for	for	ADP
admet-923	314	20	metabolic	metabolic	NOUN
admet-923	314	21	ddi	ddi	PROPN
admet-923	314	22	prediction	prediction	NOUN
admet-923	314	23	)	)	PUNCT
admet-923	315	1	[	[	X
admet-923	315	2	21,144	21,144	NUM
admet-923	315	3	]	]	PUNCT
admet-923	315	4	.	.	PUNCT
admet-923	316	1	to	to	PART
admet-923	316	2	explain	explain	VERB
admet-923	316	3	and	and	CCONJ
admet-923	316	4	predict	predict	VERB
admet-923	316	5	complex	complex	ADJ
admet-923	316	6	pharmacokinetics	pharmacokinetic	NOUN
admet-923	316	7	and	and	CCONJ
admet-923	316	8	population	population	NOUN
admet-923	316	9	variation	variation	NOUN
admet-923	316	10	in	in	ADP
admet-923	316	11	late	late	ADJ
admet-923	316	12	drug	drug	NOUN
admet-923	316	13	development	development	NOUN
admet-923	316	14	and	and	CCONJ
admet-923	316	15	product	product	NOUN
admet-923	316	16	life	life	NOUN
admet-923	316	17	-	-	PUNCT
admet-923	316	18	cycle	cycle	NOUN
admet-923	316	19	management	management	NOUN
admet-923	316	20	,	,	PUNCT
admet-923	316	21	a	a	DET
admet-923	316	22	pbpk	pbpk	ADJ
admet-923	316	23	model	model	NOUN
admet-923	316	24	should	should	AUX
admet-923	316	25	have	have	VERB
admet-923	316	26	sufficient	sufficient	ADJ
admet-923	316	27	components	component	NOUN
admet-923	316	28	.	.	PUNCT
admet-923	317	1	commercial	commercial	ADJ
admet-923	317	2	software	software	NOUN
admet-923	317	3	products	product	NOUN
admet-923	317	4	that	that	PRON
admet-923	317	5	implements	implement	VERB
admet-923	317	6	a	a	DET
admet-923	317	7	complex	complex	ADJ
admet-923	317	8	dynamic	dynamic	ADJ
admet-923	317	9	oa	oa	ADP
admet-923	317	10	pbpk	pbpk	NOUN
admet-923	317	11	model	model	NOUN
admet-923	317	12	would	would	AUX
admet-923	317	13	be	be	AUX
admet-923	317	14	especially	especially	ADV
admet-923	317	15	useful	useful	ADJ
admet-923	317	16	for	for	ADP
admet-923	317	17	these	these	DET
admet-923	317	18	purposes	purpose	NOUN
admet-923	317	19	.	.	PUNCT
admet-923	318	1	https://doi.org/10.5599/admet.923	https://doi.org/10.5599/admet.923	X
admet-923	318	2	kiyohiko	kiyohiko	PROPN
admet-923	318	3	sugano	sugano	PROPN
admet-923	318	4	admet	admet	PROPN
admet-923	318	5	&	&	CCONJ
admet-923	318	6	dmpk	dmpk	PROPN
admet-923	318	7	9(2	9(2	NUM
admet-923	318	8	)	)	PUNCT
admet-923	318	9	(	(	PUNCT
admet-923	318	10	2021	2021	NUM
admet-923	318	11	)	)	PUNCT
admet-923	318	12	75	75	NUM
admet-923	318	13	-	-	SYM
admet-923	318	14	109	109	NUM
admet-923	318	15	86	86	NUM
admet-923	318	16	part	part	NOUN
admet-923	318	17	3	3	NUM
admet-923	318	18	:	:	PUNCT
admet-923	318	19	middle	middle	ADJ
admet-923	318	20	-	-	PUNCT
admet-923	318	21	out	out	NOUN
admet-923	318	22	approach	approach	NOUN
admet-923	318	23	part	part	NOUN
admet-923	318	24	2	2	NUM
admet-923	318	25	discussed	discuss	VERB
admet-923	318	26	the	the	DET
admet-923	318	27	interpretation	interpretation	NOUN
admet-923	318	28	and	and	CCONJ
admet-923	318	29	evaluation	evaluation	NOUN
admet-923	318	30	of	of	ADP
admet-923	318	31	the	the	DET
admet-923	318	32	pbpk	pbpk	ADJ
admet-923	318	33	model	model	NOUN
admet-923	318	34	.	.	PUNCT
admet-923	319	1	one	one	NUM
admet-923	319	2	of	of	ADP
admet-923	319	3	the	the	DET
admet-923	319	4	most	most	ADV
admet-923	319	5	difficult	difficult	ADJ
admet-923	319	6	parts	part	NOUN
admet-923	319	7	of	of	ADP
admet-923	319	8	evaluating	evaluate	VERB
admet-923	319	9	a	a	DET
admet-923	319	10	pbpk	pbpk	ADJ
admet-923	319	11	model	model	NOUN
admet-923	319	12	is	be	AUX
admet-923	319	13	the	the	DET
admet-923	319	14	validity	validity	NOUN
admet-923	319	15	of	of	ADP
admet-923	319	16	the	the	DET
admet-923	319	17	middle	middle	ADJ
admet-923	319	18	-	-	PUNCT
admet-923	319	19	out	out	ADP
admet-923	319	20	approach	approach	NOUN
admet-923	319	21	.	.	PUNCT
admet-923	320	1	therefore	therefore	ADV
admet-923	320	2	,	,	PUNCT
admet-923	320	3	middle	middle	ADJ
admet-923	320	4	-	-	PUNCT
admet-923	320	5	out	out	ADP
admet-923	320	6	approaches	approach	NOUN
admet-923	320	7	are	be	AUX
admet-923	320	8	discussed	discuss	VERB
admet-923	320	9	in	in	ADP
admet-923	320	10	this	this	DET
admet-923	320	11	part	part	NOUN
admet-923	320	12	.	.	PUNCT
admet-923	321	1	middle	middle	ADJ
admet-923	321	2	-	-	PUNCT
admet-923	321	3	out	out	ADP
admet-923	321	4	approaches	approach	NOUN
admet-923	321	5	have	have	AUX
admet-923	321	6	been	be	AUX
admet-923	321	7	widely	widely	ADV
admet-923	321	8	utilized	utilize	VERB
admet-923	321	9	in	in	ADP
admet-923	321	10	real	real	ADJ
admet-923	321	11	drug	drug	NOUN
admet-923	321	12	discovery	discovery	NOUN
admet-923	321	13	and	and	CCONJ
admet-923	321	14	development	development	NOUN
admet-923	321	15	[	[	X
admet-923	321	16	21	21	NUM
admet-923	321	17	]	]	PUNCT
admet-923	321	18	.	.	PUNCT
admet-923	322	1	they	they	PRON
admet-923	322	2	would	would	AUX
admet-923	322	3	be	be	AUX
admet-923	322	4	effective	effective	ADJ
admet-923	322	5	to	to	PART
admet-923	322	6	improve	improve	VERB
admet-923	322	7	various	various	ADJ
admet-923	322	8	processes	process	NOUN
admet-923	322	9	in	in	ADP
admet-923	322	10	drug	drug	NOUN
admet-923	322	11	development	development	NOUN
admet-923	322	12	.	.	PUNCT
admet-923	323	1	at	at	ADP
admet-923	323	2	the	the	DET
admet-923	323	3	same	same	ADJ
admet-923	323	4	time	time	NOUN
admet-923	323	5	,	,	PUNCT
admet-923	323	6	if	if	SCONJ
admet-923	323	7	they	they	PRON
admet-923	323	8	are	be	AUX
admet-923	323	9	inappropriately	inappropriately	ADV
admet-923	323	10	used	use	VERB
admet-923	323	11	,	,	PUNCT
admet-923	323	12	they	they	PRON
admet-923	323	13	could	could	AUX
admet-923	323	14	cause	cause	VERB
admet-923	323	15	trouble	trouble	NOUN
admet-923	323	16	.	.	PUNCT
admet-923	324	1	the	the	DET
admet-923	324	2	purpose	purpose	NOUN
admet-923	324	3	of	of	ADP
admet-923	324	4	this	this	DET
admet-923	324	5	section	section	NOUN
admet-923	324	6	is	be	AUX
admet-923	324	7	to	to	PART
admet-923	324	8	discuss	discuss	VERB
admet-923	324	9	how	how	SCONJ
admet-923	324	10	to	to	PART
admet-923	324	11	properly	properly	ADV
admet-923	324	12	use	use	VERB
admet-923	324	13	the	the	DET
admet-923	324	14	middle	middle	ADJ
admet-923	324	15	-	-	PUNCT
admet-923	324	16	out	out	ADP
admet-923	324	17	approach	approach	NOUN
admet-923	324	18	in	in	ADP
admet-923	324	19	oa	oa	PROPN
admet-923	324	20	pbpk	pbpk	NOUN
admet-923	324	21	modelling	modelling	NOUN
admet-923	324	22	.	.	PUNCT
admet-923	325	1	3.1	3.1	NUM
admet-923	325	2	.	.	PUNCT
admet-923	326	1	the	the	DET
admet-923	326	2	concept	concept	NOUN
admet-923	326	3	of	of	ADP
admet-923	326	4	the	the	DET
admet-923	326	5	middle	middle	ADJ
admet-923	326	6	-	-	PUNCT
admet-923	326	7	out	out	ADP
admet-923	326	8	approach	approach	NOUN
admet-923	326	9	in	in	ADP
admet-923	326	10	a	a	DET
admet-923	326	11	middle	middle	ADJ
admet-923	326	12	-	-	PUNCT
admet-923	326	13	out	out	ADP
admet-923	326	14	approach	approach	NOUN
admet-923	326	15	,	,	PUNCT
admet-923	326	16	some	some	DET
admet-923	326	17	parameters	parameter	NOUN
admet-923	326	18	of	of	ADP
admet-923	326	19	a	a	DET
admet-923	326	20	pbpk	pbpk	ADJ
admet-923	326	21	model	model	NOUN
admet-923	326	22	are	be	AUX
admet-923	326	23	derived	derive	VERB
admet-923	326	24	from	from	ADP
admet-923	326	25	in	in	ADP
admet-923	326	26	vitro	vitro	X
admet-923	326	27	data	datum	NOUN
admet-923	326	28	(	(	PUNCT
admet-923	326	29	bottom	bottom	NOUN
admet-923	326	30	-	-	PUNCT
admet-923	326	31	up	up	NOUN
admet-923	326	32	)	)	PUNCT
admet-923	326	33	,	,	PUNCT
admet-923	326	34	while	while	SCONJ
admet-923	326	35	others	other	NOUN
admet-923	326	36	are	be	AUX
admet-923	326	37	derived	derive	VERB
admet-923	326	38	from	from	ADP
admet-923	326	39	clinical	clinical	ADJ
admet-923	326	40	pk	pk	NOUN
admet-923	326	41	data	datum	NOUN
admet-923	326	42	(	(	PUNCT
admet-923	326	43	top	top	NOUN
admet-923	326	44	-	-	PUNCT
admet-923	326	45	down	down	NOUN
admet-923	326	46	)	)	PUNCT
admet-923	326	47	on	on	ADP
admet-923	326	48	a	a	DET
admet-923	326	49	drug	drug	NOUN
admet-923	326	50	-	-	PUNCT
admet-923	326	51	by	by	ADP
admet-923	326	52	-	-	PUNCT
admet-923	326	53	drug	drug	NOUN
admet-923	326	54	basis	basis	NOUN
admet-923	326	55	(	(	PUNCT
admet-923	326	56	see	see	VERB
admet-923	326	57	also	also	ADV
admet-923	326	58	section	section	VERB
admet-923	326	59	3.14	3.14	NUM
admet-923	326	60	)	)	PUNCT
admet-923	326	61	.	.	PUNCT
admet-923	327	1	in	in	ADP
admet-923	327	2	the	the	DET
admet-923	327	3	following	follow	VERB
admet-923	327	4	sections	section	NOUN
admet-923	327	5	,	,	PUNCT
admet-923	327	6	this	this	DET
admet-923	327	7	prediction	prediction	NOUN
admet-923	327	8	scheme	scheme	NOUN
admet-923	327	9	is	be	AUX
admet-923	327	10	referred	refer	VERB
admet-923	327	11	to	to	ADP
admet-923	327	12	as	as	ADP
admet-923	327	13	a	a	DET
admet-923	327	14	“	"	PUNCT
admet-923	327	15	local	local	ADJ
admet-923	327	16	(	(	PUNCT
admet-923	327	17	drug	drug	NOUN
admet-923	327	18	-	-	PUNCT
admet-923	327	19	by	by	ADP
admet-923	327	20	-	-	PUNCT
admet-923	327	21	drug	drug	NOUN
admet-923	327	22	)	)	PUNCT
admet-923	327	23	”	"	PUNCT
admet-923	327	24	middle	middle	ADJ
admet-923	327	25	-	-	PUNCT
admet-923	327	26	out	out	NOUN
admet-923	327	27	approach	approach	NOUN
admet-923	327	28	to	to	PART
admet-923	327	29	differentiate	differentiate	VERB
admet-923	327	30	it	it	PRON
admet-923	327	31	from	from	ADP
admet-923	327	32	a	a	DET
admet-923	327	33	“	"	PUNCT
admet-923	327	34	global	global	ADJ
admet-923	327	35	”	"	PUNCT
admet-923	327	36	middle	middle	ADJ
admet-923	327	37	-	-	PUNCT
admet-923	327	38	out	out	ADP
admet-923	327	39	approach	approach	NOUN
admet-923	327	40	(	(	PUNCT
admet-923	327	41	section	section	NOUN
admet-923	327	42	3.15	3.15	NUM
admet-923	327	43	)	)	PUNCT
admet-923	328	1	[	[	X
admet-923	328	2	145	145	NUM
admet-923	328	3	]	]	PUNCT
admet-923	328	4	.	.	PUNCT
admet-923	329	1	for	for	ADP
admet-923	329	2	drug	drug	NOUN
admet-923	329	3	-	-	PUNCT
admet-923	329	4	drug	drug	NOUN
admet-923	329	5	interaction	interaction	NOUN
admet-923	329	6	(	(	PUNCT
admet-923	329	7	ddi	ddi	PROPN
admet-923	329	8	)	)	PUNCT
admet-923	329	9	prediction	prediction	NOUN
admet-923	329	10	,	,	PUNCT
admet-923	329	11	the	the	DET
admet-923	329	12	local	local	ADJ
admet-923	329	13	middle	middle	ADJ
admet-923	329	14	-	-	PUNCT
admet-923	329	15	out	out	ADP
admet-923	329	16	approach	approach	NOUN
admet-923	329	17	using	use	VERB
admet-923	329	18	a	a	DET
admet-923	329	19	cyp	cyp	ADJ
admet-923	329	20	specific	specific	ADJ
admet-923	329	21	inhibitor	inhibitor	NOUN
admet-923	329	22	or	or	CCONJ
admet-923	329	23	substrate	substrate	NOUN
admet-923	329	24	has	have	AUX
admet-923	329	25	been	be	AUX
admet-923	329	26	successfully	successfully	ADV
admet-923	329	27	used	use	VERB
admet-923	329	28	[	[	PUNCT
admet-923	329	29	21	21	NUM
admet-923	329	30	]	]	X
admet-923	329	31	(	(	PUNCT
admet-923	329	32	section	section	NOUN
admet-923	329	33	3.12	3.12	NUM
admet-923	329	34	)	)	PUNCT
admet-923	329	35	.	.	PUNCT
admet-923	330	1	however	however	ADV
admet-923	330	2	,	,	PUNCT
admet-923	330	3	it	it	PRON
admet-923	330	4	has	have	AUX
admet-923	330	5	been	be	AUX
admet-923	330	6	pointed	point	VERB
admet-923	330	7	out	out	ADP
admet-923	330	8	that	that	SCONJ
admet-923	330	9	the	the	DET
admet-923	330	10	inappropriate	inappropriate	ADJ
admet-923	330	11	use	use	NOUN
admet-923	330	12	of	of	ADP
admet-923	330	13	a	a	DET
admet-923	330	14	local	local	ADJ
admet-923	330	15	middle	middle	ADJ
admet-923	330	16	-	-	PUNCT
admet-923	330	17	out	out	ADP
admet-923	330	18	approach	approach	NOUN
admet-923	330	19	reduces	reduce	VERB
admet-923	330	20	the	the	DET
admet-923	330	21	creditability	creditability	NOUN
admet-923	330	22	of	of	ADP
admet-923	330	23	oa	oa	PROPN
admet-923	330	24	pbpk	pbpk	NOUN
admet-923	330	25	modelling	model	VERB
admet-923	330	26	[	[	X
admet-923	330	27	17,20	17,20	NUM
admet-923	330	28	]	]	X
admet-923	330	29	.	.	PUNCT
admet-923	331	1	a	a	DET
admet-923	331	2	middle	middle	ADJ
admet-923	331	3	-	-	PUNCT
admet-923	331	4	out	out	ADP
admet-923	331	5	approach	approach	NOUN
admet-923	331	6	brings	bring	VERB
admet-923	331	7	an	an	DET
admet-923	331	8	empirical	empirical	ADJ
admet-923	331	9	model	model	NOUN
admet-923	331	10	into	into	ADP
admet-923	331	11	pbpk	pbpk	NOUN
admet-923	331	12	modelling	modelling	NOUN
admet-923	331	13	(	(	PUNCT
admet-923	331	14	figure	figure	NOUN
admet-923	331	15	5	5	NUM
admet-923	331	16	,	,	PUNCT
admet-923	331	17	the	the	DET
admet-923	331	18	red	red	ADJ
admet-923	331	19	line	line	NOUN
admet-923	331	20	and	and	CCONJ
admet-923	331	21	square	square	NOUN
admet-923	331	22	)	)	PUNCT
admet-923	331	23	.	.	PUNCT
admet-923	332	1	therefore	therefore	ADV
admet-923	332	2	,	,	PUNCT
admet-923	332	3	we	we	PRON
admet-923	332	4	should	should	AUX
admet-923	332	5	follow	follow	VERB
admet-923	332	6	the	the	DET
admet-923	332	7	good	good	ADJ
admet-923	332	8	practice	practice	NOUN
admet-923	332	9	of	of	ADP
admet-923	332	10	empirical	empirical	ADJ
admet-923	332	11	modelling	modelling	NOUN
admet-923	332	12	:	:	PUNCT
admet-923	332	13	(	(	PUNCT
admet-923	332	14	i	i	NOUN
admet-923	332	15	)	)	PUNCT
admet-923	332	16	before	before	ADP
admet-923	332	17	back	back	NOUN
admet-923	332	18	-	-	PUNCT
admet-923	332	19	calculation	calculation	NOUN
admet-923	332	20	,	,	PUNCT
admet-923	332	21	parameter	parameter	NOUN
admet-923	332	22	identifiability	identifiability	NOUN
admet-923	332	23	must	must	AUX
admet-923	332	24	be	be	AUX
admet-923	332	25	carefully	carefully	ADV
admet-923	332	26	examined	examine	VERB
admet-923	332	27	(	(	PUNCT
admet-923	332	28	sections	section	NOUN
admet-923	332	29	1.4	1.4	NUM
admet-923	332	30	and	and	CCONJ
admet-923	332	31	3.2	3.2	NUM
admet-923	332	32	)	)	PUNCT
admet-923	333	1	[	[	X
admet-923	333	2	18–23,32,33	18–23,32,33	NUM
admet-923	333	3	]	]	PUNCT
admet-923	333	4	.	.	PUNCT
admet-923	333	5	(	(	PUNCT
admet-923	333	6	ii	ii	NOUN
admet-923	333	7	)	)	PUNCT
admet-923	333	8	the	the	DET
admet-923	333	9	degree	degree	NOUN
admet-923	333	10	of	of	ADP
admet-923	333	11	freedom	freedom	NOUN
admet-923	333	12	must	must	AUX
admet-923	333	13	be	be	AUX
admet-923	333	14	enough	enough	ADJ
admet-923	333	15	to	to	PART
admet-923	333	16	avoid	avoid	VERB
admet-923	333	17	overfitting	overfitte	VERB
admet-923	333	18	(	(	PUNCT
admet-923	333	19	section	section	NOUN
admet-923	333	20	2.2	2.2	NUM
admet-923	333	21	,	,	PUNCT
admet-923	333	22	figure	figure	NOUN
admet-923	333	23	3	3	NUM
admet-923	333	24	)	)	PUNCT
admet-923	333	25	.	.	PUNCT
admet-923	334	1	(	(	PUNCT
admet-923	334	2	iii	iii	X
admet-923	334	3	)	)	PUNCT
admet-923	334	4	the	the	DET
admet-923	334	5	predictive	predictive	ADJ
admet-923	334	6	power	power	NOUN
admet-923	334	7	must	must	AUX
admet-923	334	8	be	be	AUX
admet-923	334	9	validated	validate	VERB
admet-923	334	10	using	use	VERB
admet-923	334	11	clinical	clinical	ADJ
admet-923	334	12	data	datum	NOUN
admet-923	334	13	that	that	PRON
admet-923	334	14	is	be	AUX
admet-923	334	15	not	not	PART
admet-923	334	16	used	use	VERB
admet-923	334	17	to	to	PART
admet-923	334	18	back	back	VERB
admet-923	334	19	-	-	PUNCT
admet-923	334	20	calculate	calculate	VERB
admet-923	334	21	the	the	DET
admet-923	334	22	parameter	parameter	NOUN
admet-923	334	23	(	(	PUNCT
admet-923	334	24	called	call	VERB
admet-923	334	25	“	"	PUNCT
admet-923	334	26	cross	cross	ADJ
admet-923	334	27	-	-	ADJ
admet-923	334	28	validation	validation	NOUN
admet-923	334	29	”	"	PUNCT
admet-923	334	30	)	)	PUNCT
admet-923	334	31	(	(	PUNCT
admet-923	334	32	section	section	NOUN
admet-923	334	33	3.11	3.11	NUM
admet-923	334	34	)	)	PUNCT
admet-923	334	35	.	.	PUNCT
admet-923	335	1	(	(	PUNCT
admet-923	335	2	iv	iv	X
admet-923	335	3	)	)	PUNCT
admet-923	335	4	the	the	DET
admet-923	335	5	optimized	optimize	VERB
admet-923	335	6	empirical	empirical	ADJ
admet-923	335	7	model	model	NOUN
admet-923	335	8	should	should	AUX
admet-923	335	9	be	be	AUX
admet-923	335	10	used	use	VERB
admet-923	335	11	within	within	ADP
admet-923	335	12	the	the	DET
admet-923	335	13	parameter	parameter	NOUN
admet-923	335	14	space	space	NOUN
admet-923	335	15	limited	limit	VERB
admet-923	335	16	by	by	ADP
admet-923	335	17	the	the	DET
admet-923	335	18	data	datum	NOUN
admet-923	335	19	used	use	VERB
admet-923	335	20	for	for	ADP
admet-923	335	21	back	back	NOUN
admet-923	335	22	-	-	PUNCT
admet-923	335	23	calculation	calculation	NOUN
admet-923	335	24	(	(	PUNCT
admet-923	335	25	so	so	SCONJ
admet-923	335	26	that	that	SCONJ
admet-923	335	27	as	as	ADP
admet-923	335	28	interpolation	interpolation	NOUN
admet-923	335	29	)	)	PUNCT
admet-923	335	30	(	(	PUNCT
admet-923	335	31	this	this	PRON
admet-923	335	32	is	be	AUX
admet-923	335	33	a	a	DET
admet-923	335	34	general	general	ADJ
admet-923	335	35	recommendation	recommendation	NOUN
admet-923	335	36	for	for	ADP
admet-923	335	37	empirical	empirical	ADJ
admet-923	335	38	models	model	NOUN
admet-923	335	39	.	.	PUNCT
admet-923	336	1	for	for	ADP
admet-923	336	2	the	the	DET
admet-923	336	3	hybrid	hybrid	NOUN
admet-923	336	4	of	of	ADP
admet-923	336	5	empirical	empirical	ADJ
admet-923	336	6	and	and	CCONJ
admet-923	336	7	mechanistic	mechanistic	ADJ
admet-923	336	8	models	model	NOUN
admet-923	336	9	,	,	PUNCT
admet-923	336	10	this	this	DET
admet-923	336	11	point	point	NOUN
admet-923	336	12	(	(	PUNCT
admet-923	336	13	iv	iv	X
admet-923	336	14	)	)	PUNCT
admet-923	336	15	needs	need	VERB
admet-923	336	16	further	far	ADV
admet-923	336	17	in	in	ADP
admet-923	336	18	-	-	PUNCT
admet-923	336	19	depth	depth	NOUN
admet-923	336	20	discussion	discussion	NOUN
admet-923	336	21	.	.	PUNCT
admet-923	336	22	)	)	PUNCT
admet-923	336	23	.	.	PUNCT
admet-923	337	1	3.2	3.2	NUM
admet-923	337	2	.	.	PUNCT
admet-923	338	1	parameter	parameter	NOUN
admet-923	338	2	identifiability	identifiability	NOUN
admet-923	338	3	:	:	PUNCT
admet-923	338	4	a	a	DET
admet-923	338	5	simple	simple	ADJ
admet-923	338	6	explanation	explanation	NOUN
admet-923	338	7	the	the	DET
admet-923	338	8	issue	issue	NOUN
admet-923	338	9	of	of	ADP
admet-923	338	10	parameter	parameter	NOUN
admet-923	338	11	identifiability	identifiability	NOUN
admet-923	338	12	in	in	ADP
admet-923	338	13	biological	biological	ADJ
admet-923	338	14	mathematical	mathematical	ADJ
admet-923	338	15	modelling	modelling	NOUN
admet-923	338	16	(	(	PUNCT
admet-923	338	17	including	include	VERB
admet-923	338	18	pbpk	pbpk	PROPN
admet-923	338	19	modelling	modelling	NOUN
admet-923	338	20	)	)	PUNCT
admet-923	338	21	has	have	AUX
admet-923	338	22	been	be	AUX
admet-923	338	23	repeatedly	repeatedly	ADV
admet-923	338	24	warned	warn	VERB
admet-923	338	25	in	in	ADP
admet-923	338	26	the	the	DET
admet-923	338	27	literature	literature	NOUN
admet-923	338	28	[	[	X
admet-923	338	29	18–24	18–24	NUM
admet-923	338	30	]	]	PUNCT
admet-923	338	31	.	.	PUNCT
admet-923	339	1	however	however	ADV
admet-923	339	2	,	,	PUNCT
admet-923	339	3	this	this	DET
admet-923	339	4	issue	issue	NOUN
admet-923	339	5	seems	seem	VERB
admet-923	339	6	to	to	PART
admet-923	339	7	have	have	AUX
admet-923	339	8	been	be	AUX
admet-923	339	9	overlooked	overlook	VERB
admet-923	339	10	in	in	ADP
admet-923	339	11	many	many	ADJ
admet-923	339	12	case	case	NOUN
admet-923	339	13	studies	study	NOUN
admet-923	339	14	using	use	VERB
admet-923	339	15	a	a	DET
admet-923	339	16	local	local	ADJ
admet-923	339	17	middle	middle	ADJ
admet-923	339	18	-	-	PUNCT
admet-923	339	19	out	out	ADP
admet-923	339	20	approach	approach	NOUN
admet-923	339	21	.	.	PUNCT
admet-923	340	1	in	in	ADP
admet-923	340	2	this	this	DET
admet-923	340	3	section	section	NOUN
admet-923	340	4	,	,	PUNCT
admet-923	340	5	parameter	parameter	NOUN
admet-923	340	6	identifiability	identifiability	NOUN
admet-923	340	7	is	be	AUX
admet-923	340	8	plainly	plainly	ADV
admet-923	340	9	explained	explain	VERB
admet-923	340	10	focusing	focus	VERB
admet-923	340	11	on	on	ADP
admet-923	340	12	oa	oa	ADP
admet-923	340	13	pbpk	pbpk	NOUN
admet-923	340	14	modelling	modelling	NOUN
admet-923	340	15	.	.	PUNCT
admet-923	341	1	in	in	ADP
admet-923	341	2	a	a	DET
admet-923	341	3	middle	middle	ADJ
admet-923	341	4	-	-	PUNCT
admet-923	341	5	out	out	ADP
admet-923	341	6	approach	approach	NOUN
admet-923	341	7	,	,	PUNCT
admet-923	341	8	the	the	DET
admet-923	341	9	identifiability	identifiability	NOUN
admet-923	341	10	of	of	ADP
admet-923	341	11	a	a	DET
admet-923	341	12	parameter(s	parameter(s	NOUN
admet-923	341	13	)	)	PUNCT
admet-923	341	14	must	must	AUX
admet-923	341	15	be	be	AUX
admet-923	341	16	assessed	assess	VERB
admet-923	341	17	before	before	ADP
admet-923	341	18	back	back	ADV
admet-923	341	19	calculating	calculate	VERB
admet-923	341	20	the	the	DET
admet-923	341	21	parameter	parameter	NOUN
admet-923	341	22	,	,	PUNCT
admet-923	341	23	whether	whether	SCONJ
admet-923	341	24	the	the	DET
admet-923	341	25	parameter(s	parameter(s	NOUN
admet-923	341	26	)	)	PUNCT
admet-923	341	27	can	can	AUX
admet-923	341	28	be	be	AUX
admet-923	341	29	uniquely	uniquely	ADV
admet-923	341	30	and	and	CCONJ
admet-923	341	31	reliably	reliably	ADV
admet-923	341	32	identifiable	identifiable	ADJ
admet-923	341	33	from	from	ADP
admet-923	341	34	the	the	DET
admet-923	341	35	input	input	NOUN
admet-923	341	36	-	-	PUNCT
admet-923	341	37	output	output	NOUN
admet-923	341	38	data	datum	NOUN
admet-923	342	1	[	[	X
admet-923	342	2	18–24	18–24	NUM
admet-923	342	3	]	]	PUNCT
admet-923	342	4	.	.	PUNCT
admet-923	343	1	there	there	PRON
admet-923	343	2	are	be	VERB
admet-923	343	3	two	two	NUM
admet-923	343	4	types	type	NOUN
admet-923	343	5	of	of	ADP
admet-923	343	6	parameter	parameter	NOUN
admet-923	343	7	identifiability	identifiability	NOUN
admet-923	343	8	:	:	PUNCT
admet-923	343	9	statistical	statistical	ADJ
admet-923	343	10	and	and	CCONJ
admet-923	343	11	structural	structural	ADJ
admet-923	343	12	.	.	PUNCT
admet-923	344	1	statistical	statistical	ADJ
admet-923	344	2	identifiability	identifiability	NOUN
admet-923	344	3	is	be	AUX
admet-923	344	4	related	relate	VERB
admet-923	344	5	to	to	ADP
admet-923	344	6	the	the	DET
admet-923	344	7	experimental	experimental	ADJ
admet-923	344	8	error	error	NOUN
admet-923	344	9	of	of	ADP
admet-923	344	10	the	the	DET
admet-923	344	11	observed	observe	VERB
admet-923	344	12	data	datum	NOUN
admet-923	344	13	.	.	PUNCT
admet-923	345	1	however	however	ADV
admet-923	345	2	,	,	PUNCT
admet-923	345	3	even	even	ADV
admet-923	345	4	with	with	ADP
admet-923	345	5	error	error	NOUN
admet-923	345	6	-	-	PUNCT
admet-923	345	7	free	free	ADJ
admet-923	345	8	data	datum	NOUN
admet-923	345	9	,	,	PUNCT
admet-923	345	10	a	a	DET
admet-923	345	11	model	model	NOUN
admet-923	345	12	parameter	parameter	NOUN
admet-923	345	13	could	could	AUX
admet-923	345	14	be	be	AUX
admet-923	345	15	structurally	structurally	ADV
admet-923	345	16	non	non	ADJ
admet-923	345	17	-	-	ADJ
admet-923	345	18	identifiable	identifiable	ADJ
admet-923	345	19	.	.	PUNCT
admet-923	346	1	to	to	PART
admet-923	346	2	illustrate	illustrate	VERB
admet-923	346	3	the	the	DET
admet-923	346	4	concept	concept	NOUN
admet-923	346	5	of	of	ADP
admet-923	346	6	structural	structural	ADJ
admet-923	346	7	identifiability	identifiability	NOUN
admet-923	346	8	,	,	PUNCT
admet-923	346	9	let	let	VERB
admet-923	346	10	’s	’s	NOUN
admet-923	346	11	consider	consider	VERB
admet-923	346	12	an	an	DET
admet-923	346	13	equation	equation	NOUN
admet-923	346	14	of	of	ADP
admet-923	346	15	y	y	PROPN
admet-923	346	16	=	=	PUNCT
admet-923	346	17	abx	abx	PROPN
admet-923	346	18	,	,	PUNCT
admet-923	346	19	where	where	SCONJ
admet-923	346	20	x	x	PRON
admet-923	346	21	is	be	AUX
admet-923	346	22	an	an	DET
admet-923	346	23	explanatory	explanatory	ADJ
admet-923	346	24	variable	variable	NOUN
admet-923	346	25	,	,	PUNCT
admet-923	346	26	y	y	PROPN
admet-923	346	27	is	be	AUX
admet-923	346	28	an	an	DET
admet-923	346	29	object	object	NOUN
admet-923	346	30	variable	variable	NOUN
admet-923	346	31	,	,	PUNCT
admet-923	346	32	and	and	CCONJ
admet-923	346	33	a	a	PRON
admet-923	346	34	and	and	CCONJ
admet-923	346	35	b	b	NOUN
admet-923	346	36	are	be	AUX
admet-923	346	37	system	system	NOUN
admet-923	346	38	parameters	parameter	NOUN
admet-923	346	39	[	[	X
admet-923	346	40	23	23	NUM
admet-923	346	41	]	]	PUNCT
admet-923	346	42	.	.	PUNCT
admet-923	347	1	the	the	DET
admet-923	347	2	lump	lump	NOUN
admet-923	347	3	quantity	quantity	NOUN
admet-923	347	4	a·b	a·b	NOUN
admet-923	347	5	is	be	AUX
admet-923	347	6	uniquely	uniquely	ADV
admet-923	347	7	identifiable	identifiable	ADJ
admet-923	347	8	from	from	ADP
admet-923	347	9	x	x	PUNCT
admet-923	347	10	and	and	CCONJ
admet-923	347	11	y	y	PROPN
admet-923	347	12	,	,	PUNCT
admet-923	347	13	while	while	SCONJ
admet-923	347	14	the	the	DET
admet-923	347	15	individual	individual	ADJ
admet-923	347	16	parameters	parameter	NOUN
admet-923	347	17	of	of	ADP
admet-923	347	18	a	a	PRON
admet-923	347	19	and	and	CCONJ
admet-923	347	20	b	b	NOUN
admet-923	347	21	are	be	AUX
admet-923	347	22	non	non	ADJ
admet-923	347	23	-	-	ADJ
admet-923	347	24	identifiable	identifiable	ADJ
admet-923	347	25	(	(	PUNCT
admet-923	347	26	it	it	PRON
admet-923	347	27	is	be	AUX
admet-923	347	28	mathematically	mathematically	ADV
admet-923	347	29	indefinite	indefinite	ADJ
admet-923	347	30	)	)	PUNCT
admet-923	347	31	.	.	PUNCT
admet-923	348	1	even	even	ADV
admet-923	348	2	when	when	SCONJ
admet-923	348	3	multiple	multiple	ADJ
admet-923	348	4	xy	xy	PROPN
admet-923	348	5	data	datum	NOUN
admet-923	348	6	sets	set	NOUN
admet-923	348	7	are	be	AUX
admet-923	348	8	available	available	ADJ
admet-923	348	9	,	,	PUNCT
admet-923	348	10	a	a	PRON
admet-923	348	11	and	and	CCONJ
admet-923	348	12	b	b	NOUN
admet-923	348	13	are	be	AUX
admet-923	348	14	non	non	ADJ
admet-923	348	15	-	-	ADJ
admet-923	348	16	identifiable	identifiable	ADJ
admet-923	348	17	.	.	PUNCT
admet-923	349	1	therefore	therefore	ADV
admet-923	349	2	,	,	PUNCT
admet-923	349	3	a	a	PRON
admet-923	349	4	or	or	CCONJ
admet-923	349	5	b	b	NOUN
admet-923	349	6	must	must	AUX
admet-923	349	7	be	be	AUX
admet-923	349	8	fixed	fix	VERB
admet-923	349	9	separately	separately	ADV
admet-923	349	10	.	.	PUNCT
admet-923	350	1	admet	admet	PROPN
admet-923	350	2	&	&	CCONJ
admet-923	350	3	dmpk	dmpk	PROPN
admet-923	350	4	9(2	9(2	NUM
admet-923	350	5	)	)	PUNCT
admet-923	350	6	(	(	PUNCT
admet-923	350	7	2021	2021	NUM
admet-923	350	8	)	)	PUNCT
admet-923	350	9	75	75	NUM
admet-923	350	10	-	-	SYM
admet-923	350	11	109	109	NUM
admet-923	350	12	lost	lose	VERB
admet-923	350	13	in	in	ADP
admet-923	350	14	modelling	modelling	NOUN
admet-923	350	15	and	and	CCONJ
admet-923	350	16	simulation	simulation	NOUN
admet-923	350	17	?	?	PUNCT
admet-923	351	1	doi	doi	NOUN
admet-923	351	2	:	:	PUNCT
admet-923	351	3	https:/doi.org/10.5599	https:/doi.org/10.5599	PROPN
admet-923	351	4	/	/	SYM
admet-923	351	5	admet.923	admet.923	PROPN
admet-923	351	6	87	87	NUM
admet-923	351	7	figure	figure	NOUN
admet-923	351	8	5	5	NUM
admet-923	351	9	.	.	PUNCT
admet-923	351	10	bottom	bottom	ADJ
admet-923	351	11	-	-	PUNCT
admet-923	351	12	up	up	NOUN
admet-923	351	13	and	and	CCONJ
admet-923	351	14	middle	middle	ADJ
admet-923	351	15	-	-	PUNCT
admet-923	351	16	out	out	NOUN
admet-923	351	17	approaches	approach	NOUN
admet-923	351	18	for	for	ADP
admet-923	351	19	oa	oa	PROPN
admet-923	351	20	pbpk	pbpk	NOUN
admet-923	351	21	modelling	model	VERB
admet-923	351	22	.	.	PUNCT
admet-923	352	1	a	a	DET
admet-923	352	2	middle	middle	ADJ
admet-923	352	3	-	-	PUNCT
admet-923	352	4	out	out	ADP
admet-923	352	5	approach	approach	NOUN
admet-923	352	6	brings	bring	VERB
admet-923	352	7	an	an	DET
admet-923	352	8	empirical	empirical	ADJ
admet-923	352	9	model	model	NOUN
admet-923	352	10	into	into	ADP
admet-923	352	11	a	a	DET
admet-923	352	12	pbpk	pbpk	ADJ
admet-923	352	13	model	model	NOUN
admet-923	352	14	(	(	PUNCT
admet-923	352	15	the	the	DET
admet-923	352	16	red	red	ADJ
admet-923	352	17	line	line	NOUN
admet-923	352	18	and	and	CCONJ
admet-923	352	19	square	square	NOUN
admet-923	352	20	)	)	PUNCT
admet-923	352	21	.	.	PUNCT
admet-923	353	1	for	for	ADP
admet-923	353	2	parameter	parameter	NOUN
admet-923	353	3	back	back	NOUN
admet-923	353	4	calculation	calculation	NOUN
admet-923	353	5	and	and	CCONJ
admet-923	353	6	validation	validation	NOUN
admet-923	353	7	,	,	PUNCT
admet-923	353	8	separate	separate	ADJ
admet-923	353	9	clinical	clinical	ADJ
admet-923	353	10	data	datum	NOUN
admet-923	353	11	(	(	PUNCT
admet-923	353	12	fa	fa	NOUN
admet-923	353	13	,	,	PUNCT
admet-923	353	14	fa	fa	NOUN
admet-923	353	15	’	'	PUNCT
admet-923	353	16	)	)	PUNCT
admet-923	353	17	must	must	AUX
admet-923	353	18	be	be	AUX
admet-923	353	19	used	use	VERB
admet-923	353	20	.	.	PUNCT
admet-923	354	1	the	the	DET
admet-923	354	2	statistical	statistical	ADJ
admet-923	354	3	identifiability	identifiability	NOUN
admet-923	354	4	can	can	AUX
admet-923	354	5	be	be	AUX
admet-923	354	6	understood	understand	VERB
admet-923	354	7	by	by	ADP
admet-923	354	8	considering	consider	VERB
admet-923	354	9	y	y	PROPN
admet-923	354	10	=	=	SYM
admet-923	354	11	1/	1/	NUM
admet-923	354	12	(	(	PUNCT
admet-923	354	13	x	x	PROPN
admet-923	354	14	+	+	NUM
admet-923	354	15	a	a	X
admet-923	354	16	)	)	PUNCT
admet-923	354	17	.	.	PUNCT
admet-923	355	1	if	if	SCONJ
admet-923	355	2	the	the	DET
admet-923	355	3	error	error	NOUN
admet-923	355	4	of	of	ADP
admet-923	355	5	x	x	PUNCT
admet-923	355	6	is	be	AUX
admet-923	355	7	comparable	comparable	ADJ
admet-923	355	8	to	to	ADP
admet-923	355	9	a	a	PRON
admet-923	355	10	,	,	PUNCT
admet-923	355	11	a	a	PRON
admet-923	355	12	can	can	AUX
admet-923	355	13	not	not	PART
admet-923	355	14	be	be	AUX
admet-923	355	15	reliably	reliably	ADV
admet-923	355	16	determined	determined	ADJ
admet-923	355	17	(	(	PUNCT
admet-923	355	18	even	even	ADV
admet-923	355	19	assuming	assume	VERB
admet-923	355	20	zero	zero	NUM
admet-923	355	21	error	error	NOUN
admet-923	355	22	in	in	ADP
admet-923	355	23	y	y	PROPN
admet-923	355	24	)	)	PUNCT
admet-923	355	25	.	.	PUNCT
admet-923	356	1	for	for	ADP
admet-923	356	2	example	example	NOUN
admet-923	356	3	,	,	PUNCT
admet-923	356	4	when	when	SCONJ
admet-923	356	5	x	x	PROPN
admet-923	356	6	=	=	SYM
admet-923	356	7	100	100	NUM
admet-923	356	8	±	±	NUM
admet-923	356	9	10	10	NUM
admet-923	356	10	,	,	PUNCT
admet-923	356	11	we	we	PRON
admet-923	356	12	can	can	AUX
admet-923	356	13	not	not	PART
admet-923	356	14	determine	determine	VERB
admet-923	356	15	a	a	DET
admet-923	356	16	smaller	small	ADJ
admet-923	356	17	than	than	ADP
admet-923	356	18	10	10	NUM
admet-923	356	19	.	.	PUNCT
admet-923	357	1	preferably	preferably	ADV
admet-923	357	2	,	,	PUNCT
admet-923	357	3	a	a	PRON
admet-923	357	4	should	should	AUX
admet-923	357	5	be	be	AUX
admet-923	357	6	determined	determine	VERB
admet-923	357	7	at	at	ADP
admet-923	357	8	x	x	X
admet-923	357	9	<	<	X
admet-923	357	10	<	<	X
admet-923	357	11	a.	a.	NOUN
admet-923	357	12	another	another	DET
admet-923	357	13	familiar	familiar	ADJ
admet-923	357	14	example	example	NOUN
admet-923	357	15	is	be	AUX
admet-923	357	16	y	y	PROPN
admet-923	357	17	=	=	SYM
admet-923	357	18	1	1	NUM
admet-923	357	19	exp(-ax	exp(-ax	NOUN
admet-923	357	20	)	)	PUNCT
admet-923	357	21	(	(	PUNCT
admet-923	357	22	figure	figure	NOUN
admet-923	357	23	6	6	NUM
admet-923	357	24	)	)	PUNCT
admet-923	357	25	.	.	PUNCT
admet-923	358	1	in	in	ADP
admet-923	358	2	this	this	DET
admet-923	358	3	case	case	NOUN
admet-923	358	4	,	,	PUNCT
admet-923	358	5	ax	ax	NOUN
admet-923	358	6	should	should	AUX
admet-923	358	7	be	be	AUX
admet-923	358	8	<	<	X
admet-923	358	9	1.5	1.5	NUM
admet-923	358	10	if	if	SCONJ
admet-923	358	11	y	y	PROPN
admet-923	358	12	has	have	VERB
admet-923	358	13	a	a	DET
admet-923	358	14	20	20	NUM
admet-923	358	15	%	%	NOUN
admet-923	358	16	error	error	NOUN
admet-923	358	17	.	.	PUNCT
admet-923	359	1	the	the	DET
admet-923	359	2	other	other	ADJ
admet-923	359	3	simple	simple	ADJ
admet-923	359	4	examples	example	NOUN
admet-923	359	5	of	of	ADP
admet-923	359	6	parameter	parameter	NOUN
admet-923	359	7	identifiability	identifiability	NOUN
admet-923	359	8	are	be	AUX
admet-923	359	9	shown	show	VERB
admet-923	359	10	in	in	ADP
admet-923	359	11	supplemental	supplemental	ADJ
admet-923	359	12	information	information	NOUN
admet-923	359	13	.	.	PUNCT
admet-923	360	1	figure	figure	VERB
admet-923	360	2	6	6	NUM
admet-923	360	3	.	.	PUNCT
admet-923	361	1	y	y	NOUN
admet-923	361	2	=	=	SYM
admet-923	361	3	1	1	NUM
admet-923	361	4	–	–	PUNCT
admet-923	361	5	exp	exp	NOUN
admet-923	361	6	(	(	PUNCT
admet-923	361	7	-ax	-ax	NOUN
admet-923	361	8	)	)	PUNCT
admet-923	361	9	.	.	PUNCT
admet-923	362	1	3.3	3.3	NUM
admet-923	362	2	.	.	PUNCT
admet-923	363	1	local	local	ADJ
admet-923	363	2	middle	middle	ADJ
admet-923	363	3	-	-	PUNCT
admet-923	363	4	out	out	ADP
admet-923	363	5	approach	approach	NOUN
admet-923	363	6	to	to	PART
admet-923	363	7	predict	predict	VERB
admet-923	363	8	the	the	DET
admet-923	363	9	food	food	NOUN
admet-923	363	10	effect	effect	NOUN
admet-923	363	11	:	:	PUNCT
admet-923	363	12	an	an	DET
admet-923	363	13	example	example	NOUN
admet-923	363	14	to	to	PART
admet-923	363	15	overview	overview	VERB
admet-923	363	16	the	the	DET
admet-923	363	17	process	process	NOUN
admet-923	363	18	of	of	ADP
admet-923	363	19	a	a	DET
admet-923	363	20	local	local	ADJ
admet-923	363	21	middle	middle	ADJ
admet-923	363	22	-	-	PUNCT
admet-923	363	23	out	out	ADP
admet-923	363	24	approach	approach	NOUN
admet-923	363	25	and	and	CCONJ
admet-923	363	26	understand	understand	VERB
admet-923	363	27	the	the	DET
admet-923	363	28	importance	importance	NOUN
admet-923	363	29	of	of	ADP
admet-923	363	30	parameter	parameter	NOUN
admet-923	363	31	identifiability	identifiability	NOUN
admet-923	363	32	,	,	PUNCT
admet-923	363	33	in	in	ADP
admet-923	363	34	this	this	DET
admet-923	363	35	section	section	NOUN
admet-923	363	36	,	,	PUNCT
admet-923	363	37	we	we	PRON
admet-923	363	38	look	look	VERB
admet-923	363	39	at	at	ADP
admet-923	363	40	a	a	DET
admet-923	363	41	simple	simple	ADJ
admet-923	363	42	example	example	NOUN
admet-923	363	43	of	of	ADP
admet-923	363	44	oa	oa	PROPN
admet-923	363	45	pbpk	pbpk	NOUN
admet-923	363	46	modelling	model	VERB
admet-923	363	47	using	use	VERB
admet-923	363	48	a	a	DET
admet-923	363	49	local	local	ADJ
admet-923	363	50	middle	middle	ADJ
admet-923	363	51	-	-	PUNCT
admet-923	363	52	out	out	ADP
admet-923	363	53	approach	approach	NOUN
admet-923	363	54	and	and	CCONJ
admet-923	363	55	then	then	ADV
admet-923	363	56	discuss	discuss	VERB
admet-923	363	57	the	the	DET
admet-923	363	58	checkpoints	checkpoint	NOUN
admet-923	363	59	.	.	PUNCT
admet-923	364	1	https://doi.org/10.5599/admet.923	https://doi.org/10.5599/admet.923	X
admet-923	364	2	kiyohiko	kiyohiko	PROPN
admet-923	364	3	sugano	sugano	PROPN
admet-923	364	4	admet	admet	PROPN
admet-923	364	5	&	&	CCONJ
admet-923	364	6	dmpk	dmpk	PROPN
admet-923	364	7	9(2	9(2	NUM
admet-923	364	8	)	)	PUNCT
admet-923	364	9	(	(	PUNCT
admet-923	364	10	2021	2021	NUM
admet-923	364	11	)	)	PUNCT
admet-923	364	12	75	75	NUM
admet-923	364	13	-	-	SYM
admet-923	364	14	109	109	NUM
admet-923	364	15	88	88	NUM
admet-923	364	16	step	step	NOUN
admet-923	364	17	1	1	NUM
admet-923	364	18	:	:	PUNCT
admet-923	364	19	problem	problem	NOUN
admet-923	364	20	statement	statement	NOUN
admet-923	364	21	the	the	DET
admet-923	364	22	drug	drug	NOUN
admet-923	364	23	candidate	candidate	NOUN
admet-923	364	24	is	be	AUX
admet-923	364	25	a	a	DET
admet-923	364	26	poorly	poorly	ADV
admet-923	364	27	soluble	soluble	ADJ
admet-923	364	28	non	non	ADJ
admet-923	364	29	-	-	ADJ
admet-923	364	30	ionizable	ionizable	ADJ
admet-923	364	31	compound	compound	NOUN
admet-923	364	32	.	.	PUNCT
admet-923	365	1	the	the	DET
admet-923	365	2	formulation	formulation	NOUN
admet-923	365	3	is	be	AUX
admet-923	365	4	a	a	DET
admet-923	365	5	simple	simple	ADJ
admet-923	365	6	immediaterelease	immediaterelease	NOUN
admet-923	365	7	formulation	formulation	NOUN
admet-923	365	8	.	.	PUNCT
admet-923	366	1	drug	drug	NOUN
admet-923	366	2	parameters	parameter	NOUN
admet-923	366	3	are	be	AUX
admet-923	366	4	available	available	ADJ
admet-923	366	5	from	from	ADP
admet-923	366	6	preclinical	preclinical	NOUN
admet-923	366	7	in	in	ADP
admet-923	366	8	vitro	vitro	X
admet-923	366	9	studies	study	NOUN
admet-923	366	10	(	(	PUNCT
admet-923	366	11	table	table	NOUN
admet-923	366	12	1	1	NUM
admet-923	366	13	)	)	PUNCT
admet-923	366	14	.	.	PUNCT
admet-923	367	1	the	the	DET
admet-923	367	2	physiological	physiological	ADJ
admet-923	367	3	data	datum	NOUN
admet-923	367	4	are	be	AUX
admet-923	367	5	provided	provide	VERB
admet-923	367	6	as	as	ADP
admet-923	367	7	default	default	NOUN
admet-923	367	8	values	value	NOUN
admet-923	367	9	.	.	PUNCT
admet-923	368	1	table	table	NOUN
admet-923	368	2	1	1	NUM
admet-923	368	3	.	.	PUNCT
admet-923	368	4	drug	drug	NOUN
admet-923	368	5	and	and	CCONJ
admet-923	368	6	physiological	physiological	ADJ
admet-923	368	7	parameters	parameter	NOUN
admet-923	368	8	(	(	PUNCT
admet-923	368	9	example	example	NOUN
admet-923	368	10	)	)	PUNCT
admet-923	368	11	parameter	parameter	NOUN
admet-923	368	12	value	value	NOUN
admet-923	368	13	comments	comment	NOUN
admet-923	368	14	drug	drug	PROPN
admet-923	368	15	parameter	parameter	PROPN
admet-923	368	16	permeation	permeation	NOUN
admet-923	368	17	rate	rate	NOUN
admet-923	368	18	constant	constant	ADJ
admet-923	368	19	(	(	PUNCT
admet-923	368	20	kperm	kperm	NOUN
admet-923	368	21	)	)	PUNCT
admet-923	368	22	0.1	0.1	NUM
admet-923	368	23	h-1	h-1	NOUN
admet-923	368	24	from	from	ADP
admet-923	368	25	caco-2	caco-2	NUM
admet-923	368	26	data	datum	NOUN
admet-923	368	27	(	(	PUNCT
admet-923	368	28	peff	peff	NOUN
admet-923	368	29	=	=	PUNCT
admet-923	368	30	a	a	DET
admet-923	368	31	papp	papp	NOUN
admet-923	368	32	b	b	NOUN
admet-923	368	33	)	)	PUNCT
admet-923	368	34	effective	effective	ADJ
admet-923	368	35	solubility	solubility	NOUN
admet-923	368	36	(	(	PUNCT
admet-923	368	37	s	s	NOUN
admet-923	368	38	)	)	PUNCT
admet-923	368	39	0.1	0.1	NUM
admet-923	368	40	mg	mg	PROPN
admet-923	368	41	/	/	SYM
admet-923	368	42	ml	ml	NOUN
admet-923	368	43	0.2	0.2	NUM
admet-923	368	44	mg	mg	NOUN
admet-923	368	45	/	/	SYM
admet-923	368	46	ml	ml	PROPN
admet-923	368	47	fasted	fast	VERB
admet-923	368	48	state	state	NOUN
admet-923	368	49	simulated	simulate	VERB
admet-923	368	50	intestinal	intestinal	ADJ
admet-923	368	51	fluid	fluid	NOUN
admet-923	368	52	(	(	PUNCT
admet-923	368	53	fassif	fassif	NOUN
admet-923	368	54	)	)	PUNCT
admet-923	368	55	fed	fed	PROPN
admet-923	368	56	state	state	NOUN
admet-923	368	57	simulated	simulate	VERB
admet-923	368	58	intestinal	intestinal	ADJ
admet-923	368	59	fluid	fluid	NOUN
admet-923	368	60	(	(	PUNCT
admet-923	368	61	fessif	fessif	NOUN
admet-923	368	62	)	)	PUNCT
admet-923	368	63	dose	dose	NOUN
admet-923	368	64	strength	strength	NOUN
admet-923	368	65	(	(	PUNCT
admet-923	368	66	dose	dose	PROPN
admet-923	368	67	)	)	PUNCT
admet-923	368	68	350	350	NUM
admet-923	368	69	mg	mg	PROPN
admet-923	368	70	particle	particle	NOUN
admet-923	368	71	size	size	NOUN
admet-923	368	72	5	5	NUM
admet-923	368	73	μm	μm	NOUN
admet-923	368	74	diffusion	diffusion	NOUN
admet-923	368	75	coefficient	coefficient	NOUN
admet-923	368	76	6	6	NUM
admet-923	368	77	×	×	NOUN
admet-923	368	78	10	10	NUM
admet-923	368	79	-	-	SYM
admet-923	368	80	6	6	NUM
admet-923	368	81	cm2	cm2	NOUN
admet-923	368	82	/	/	SYM
admet-923	368	83	s	s	NOUN
admet-923	368	84	physiological	physiological	ADJ
admet-923	368	85	parameter	parameter	NOUN
admet-923	368	86	small	small	ADJ
admet-923	368	87	intestinal	intestinal	ADJ
admet-923	368	88	fluid	fluid	NOUN
admet-923	368	89	volume	volume	NOUN
admet-923	368	90	(	(	PUNCT
admet-923	368	91	vsi	vsi	PROPN
admet-923	368	92	)	)	PUNCT
admet-923	368	93	1000	1000	NUM
admet-923	368	94	ml	ml	NOUN
admet-923	368	95	default	default	NOUN
admet-923	368	96	(	(	PUNCT
admet-923	368	97	see	see	VERB
admet-923	368	98	checkpoint	checkpoint	NOUN
admet-923	368	99	4	4	NUM
admet-923	368	100	)	)	PUNCT
admet-923	368	101	small	small	ADJ
admet-923	368	102	intestinal	intestinal	ADJ
admet-923	368	103	transit	transit	NOUN
admet-923	368	104	time	time	NOUN
admet-923	368	105	(	(	PUNCT
admet-923	368	106	tsi	tsi	PROPN
admet-923	368	107	)	)	PUNCT
admet-923	368	108	3.5	3.5	NUM
admet-923	368	109	h	h	NOUN
admet-923	368	110	default	default	NOUN
admet-923	368	111	small	small	ADJ
admet-923	368	112	intestinal	intestinal	ADJ
admet-923	368	113	radius	radius	NOUN
admet-923	368	114	(	(	PUNCT
admet-923	368	115	rsi	rsi	NOUN
admet-923	368	116	)	)	PUNCT
admet-923	368	117	1.5	1.5	NUM
admet-923	368	118	cm	cm	NOUN
admet-923	368	119	default	default	NOUN
admet-923	368	120	degree	degree	NOUN
admet-923	368	121	of	of	ADP
admet-923	368	122	flatness	flatness	NOUN
admet-923	368	123	(	(	PUNCT
admet-923	368	124	df	df	PROPN
admet-923	368	125	)	)	PUNCT
admet-923	368	126	1.7	1.7	NUM
admet-923	368	127	default	default	NOUN
admet-923	368	128	fraction	fraction	NOUN
admet-923	368	129	escaping	escape	VERB
admet-923	368	130	first	first	ADV
admet-923	368	131	pass	pass	VERB
admet-923	368	132	hepatic	hepatic	ADJ
admet-923	368	133	metabolism	metabolism	NOUN
admet-923	368	134	(	(	PUNCT
admet-923	368	135	fh	fh	PROPN
admet-923	368	136	)	)	PUNCT
admet-923	368	137	1	1	NUM
admet-923	368	138	calculated	calculate	VERB
admet-923	368	139	from	from	ADP
admet-923	368	140	i.v	i.v	PROPN
admet-923	368	141	.	.	PUNCT
admet-923	369	1	clh	clh	PROPN
admet-923	369	2	and	and	CCONJ
admet-923	369	3	hepatic	hepatic	ADJ
admet-923	369	4	flow	flow	NOUN
admet-923	369	5	now	now	ADV
admet-923	369	6	,	,	PUNCT
admet-923	369	7	the	the	DET
admet-923	369	8	clinical	clinical	ADJ
admet-923	369	9	pk	pk	NOUN
admet-923	369	10	data	datum	NOUN
admet-923	369	11	in	in	ADP
admet-923	369	12	the	the	DET
admet-923	369	13	fasted	fasted	ADJ
admet-923	369	14	state	state	NOUN
admet-923	369	15	became	become	VERB
admet-923	369	16	available	available	ADJ
admet-923	369	17	after	after	ADP
admet-923	369	18	the	the	DET
admet-923	369	19	first	first	ADJ
admet-923	369	20	-	-	PUNCT
admet-923	369	21	in	in	ADP
admet-923	369	22	-	-	PUNCT
admet-923	369	23	human	human	ADJ
admet-923	369	24	study	study	NOUN
admet-923	369	25	(	(	PUNCT
admet-923	369	26	both	both	DET
admet-923	369	27	p.o	p.o	PROPN
admet-923	369	28	.	.	PROPN
admet-923	369	29	and	and	CCONJ
admet-923	369	30	i.v	i.v	PROPN
admet-923	369	31	.	.	PUNCT
admet-923	369	32	)	)	PUNCT
admet-923	369	33	.	.	PUNCT
admet-923	370	1	the	the	DET
admet-923	370	2	bioavailability	bioavailability	NOUN
admet-923	370	3	(	(	PUNCT
admet-923	370	4	f	f	X
admet-923	370	5	)	)	PUNCT
admet-923	370	6	was	be	AUX
admet-923	370	7	0.30	0.30	NUM
admet-923	370	8	±	±	NUM
admet-923	370	9	0.15	0.15	NUM
admet-923	370	10	(	(	PUNCT
admet-923	370	11	mean	mean	PROPN
admet-923	370	12	±	±	NUM
admet-923	370	13	s.d	s.d	PROPN
admet-923	370	14	.	.	PUNCT
admet-923	370	15	)	)	PUNCT
admet-923	370	16	.	.	PUNCT
admet-923	371	1	we	we	PRON
admet-923	371	2	are	be	AUX
admet-923	371	3	asked	ask	VERB
admet-923	371	4	by	by	ADP
admet-923	371	5	the	the	DET
admet-923	371	6	managers	manager	NOUN
admet-923	371	7	to	to	PART
admet-923	371	8	predict	predict	VERB
admet-923	371	9	auc	auc	NOUN
admet-923	371	10	in	in	ADP
admet-923	371	11	the	the	DET
admet-923	371	12	fed	fed	PROPN
admet-923	371	13	state	state	NOUN
admet-923	371	14	in	in	ADP
admet-923	371	15	healthy	healthy	ADJ
admet-923	371	16	volunteers	volunteer	NOUN
admet-923	371	17	.	.	PUNCT
admet-923	372	1	to	to	PART
admet-923	372	2	utilize	utilize	VERB
admet-923	372	3	the	the	DET
admet-923	372	4	first	first	ADJ
admet-923	372	5	-	-	PUNCT
admet-923	372	6	in	in	ADP
admet-923	372	7	-	-	PUNCT
admet-923	372	8	human	human	ADJ
admet-923	372	9	clinical	clinical	ADJ
admet-923	372	10	data	datum	NOUN
admet-923	372	11	,	,	PUNCT
admet-923	372	12	we	we	PRON
admet-923	372	13	decided	decide	VERB
admet-923	372	14	to	to	PART
admet-923	372	15	conduct	conduct	VERB
admet-923	372	16	a	a	DET
admet-923	372	17	local	local	ADJ
admet-923	372	18	middle	middle	ADJ
admet-923	372	19	-	-	PUNCT
admet-923	372	20	out	out	ADP
admet-923	372	21	approach	approach	NOUN
admet-923	372	22	.	.	PUNCT
admet-923	373	1	step	step	NOUN
admet-923	373	2	2	2	NUM
admet-923	373	3	:	:	PUNCT
admet-923	373	4	model	model	NOUN
admet-923	373	5	selection	selection	NOUN
admet-923	373	6	the	the	DET
admet-923	373	7	particle	particle	NOUN
admet-923	373	8	size	size	NOUN
admet-923	373	9	is	be	AUX
admet-923	373	10	small	small	ADJ
admet-923	373	11	enough	enough	ADV
admet-923	373	12	so	so	SCONJ
admet-923	373	13	that	that	SCONJ
admet-923	373	14	the	the	DET
admet-923	373	15	drug	drug	NOUN
admet-923	373	16	dissolution	dissolution	NOUN
admet-923	373	17	process	process	NOUN
admet-923	373	18	does	do	AUX
admet-923	373	19	not	not	PART
admet-923	373	20	become	become	VERB
admet-923	373	21	the	the	DET
admet-923	373	22	rate	rate	NOUN
admet-923	373	23	-	-	PUNCT
admet-923	373	24	limiting	limit	VERB
admet-923	373	25	step	step	NOUN
admet-923	373	26	[	[	X
admet-923	373	27	70–72	70–72	NOUN
admet-923	373	28	]	]	PUNCT
admet-923	373	29	.	.	PUNCT
admet-923	374	1	in	in	ADP
admet-923	374	2	addition	addition	NOUN
admet-923	374	3	,	,	PUNCT
admet-923	374	4	because	because	SCONJ
admet-923	374	5	the	the	DET
admet-923	374	6	drug	drug	NOUN
admet-923	374	7	is	be	AUX
admet-923	374	8	non	non	ADJ
admet-923	374	9	-	-	ADJ
admet-923	374	10	ionizable	ionizable	ADJ
admet-923	374	11	,	,	PUNCT
admet-923	374	12	gastric	gastric	ADJ
admet-923	374	13	dissolution	dissolution	NOUN
admet-923	374	14	would	would	AUX
admet-923	374	15	have	have	VERB
admet-923	374	16	little	little	ADJ
admet-923	374	17	effect	effect	NOUN
admet-923	374	18	on	on	ADP
admet-923	374	19	f.	f.	PROPN
admet-923	374	20	in	in	ADP
admet-923	374	21	the	the	DET
admet-923	374	22	case	case	NOUN
admet-923	374	23	of	of	ADP
admet-923	374	24	solubility	solubility	NOUN
admet-923	374	25	limited	limit	VERB
admet-923	374	26	oral	oral	ADJ
admet-923	374	27	absorption	absorption	NOUN
admet-923	374	28	,	,	PUNCT
admet-923	374	29	f	f	PROPN
admet-923	374	30	can	can	AUX
admet-923	374	31	be	be	AUX
admet-923	374	32	calculated	calculate	VERB
admet-923	374	33	as	as	ADP
admet-923	374	34	[	[	X
admet-923	374	35	146	146	NUM
admet-923	374	36	]	]	X
admet-923	374	37	:	:	PUNCT
admet-923	374	38	g	g	NOUN
admet-923	374	39	h	h	NOUN
admet-923	374	40	perm	perm	NOUN
admet-923	374	41	si	si	INTJ
admet-923	375	1	si	si	PROPN
admet-923	375	2	a	a	DET
admet-923	375	3	g	g	NOUN
admet-923	375	4	h	h	NOUN
admet-923	375	5	g	g	NOUN
admet-923	376	1	h	h	NOUN
admet-923	377	1	f	f	PROPN
admet-923	377	2	f	f	PROPN
admet-923	378	1	k	k	PROPN
admet-923	378	2	sv	sv	PROPN
admet-923	379	1	tpn	tpn	PROPN
admet-923	379	2	f	f	PROPN
admet-923	380	1	f	f	PROPN
admet-923	380	2	f	f	PROPN
admet-923	381	1	f	f	PROPN
admet-923	381	2	f	f	PROPN
admet-923	381	3	f	f	X
admet-923	381	4	do	do	AUX
admet-923	381	5	dose	dose	VERB
admet-923	381	6			PROPN
admet-923	381	7			ADJ
admet-923	381	8			NOUN
admet-923	381	9	(	(	PUNCT
admet-923	381	10	1	1	NUM
admet-923	381	11	)	)	PUNCT
admet-923	381	12	where	where	SCONJ
admet-923	381	13	pn	pn	PROPN
admet-923	381	14	is	be	AUX
admet-923	381	15	the	the	DET
admet-923	381	16	permeation	permeation	NOUN
admet-923	381	17	number	number	NOUN
admet-923	381	18	(=	(=	NOUN
admet-923	381	19	kperm	kperm	PROPN
admet-923	381	20	×tsi	×tsi	NUM
admet-923	381	21	)	)	PUNCT
admet-923	381	22	,	,	PUNCT
admet-923	381	23	and	and	CCONJ
admet-923	381	24	do	do	VERB
admet-923	381	25	is	be	AUX
admet-923	381	26	the	the	DET
admet-923	381	27	dose	dose	NOUN
admet-923	381	28	number	number	NOUN
admet-923	381	29	do	do	VERB
admet-923	381	30	=	=	SYM
admet-923	381	31	dose/	dose/	NUM
admet-923	381	32	(	(	PUNCT
admet-923	381	33	s	s	PROPN
admet-923	381	34	×vsi	×vsi	NOUN
admet-923	381	35	)	)	PUNCT
admet-923	381	36	.	.	PUNCT
admet-923	382	1	fg	fg	PROPN
admet-923	382	2	is	be	AUX
admet-923	382	3	the	the	DET
admet-923	382	4	fraction	fraction	NOUN
admet-923	382	5	escaping	escape	VERB
admet-923	382	6	the	the	DET
admet-923	382	7	intestinal	intestinal	ADJ
admet-923	382	8	metabolism	metabolism	NOUN
admet-923	382	9	.	.	PUNCT
admet-923	383	1	in	in	ADP
admet-923	383	2	this	this	DET
admet-923	383	3	example	example	NOUN
admet-923	383	4	,	,	PUNCT
admet-923	383	5	eq	eq	NOUN
admet-923	383	6	.	.	NOUN
admet-923	383	7	1	1	NUM
admet-923	383	8	is	be	AUX
admet-923	383	9	used	use	VERB
admet-923	383	10	as	as	ADP
admet-923	383	11	a	a	DET
admet-923	383	12	model	model	NOUN
admet-923	383	13	equation	equation	NOUN
admet-923	383	14	for	for	ADP
admet-923	383	15	convenience	convenience	NOUN
admet-923	383	16	.	.	PUNCT
admet-923	384	1	step	step	NOUN
admet-923	384	2	3	3	NUM
admet-923	384	3	:	:	PUNCT
admet-923	384	4	parameter	parameter	NOUN
admet-923	384	5	optimization	optimization	NOUN
admet-923	384	6	from	from	ADP
admet-923	384	7	eq	eq	ADP
admet-923	384	8	.	.	PROPN
admet-923	384	9	1	1	NUM
admet-923	384	10	and	and	CCONJ
admet-923	384	11	given	give	VERB
admet-923	384	12	data	datum	NOUN
admet-923	384	13	,	,	PUNCT
admet-923	384	14	kperm	kperm	NOUN
admet-923	384	15	is	be	AUX
admet-923	384	16	optimized	optimize	VERB
admet-923	384	17	to	to	PART
admet-923	384	18	be	be	AUX
admet-923	384	19	0.3	0.3	NUM
admet-923	384	20	h-1	h-1	NOUN
admet-923	384	21	in	in	ADP
admet-923	384	22	the	the	DET
admet-923	384	23	fasted	fasted	ADJ
admet-923	384	24	state	state	NOUN
admet-923	384	25	.	.	PUNCT
admet-923	385	1	step	step	NOUN
admet-923	385	2	4	4	NUM
admet-923	385	3	:	:	PUNCT
admet-923	385	4	model	model	NOUN
admet-923	385	5	validation	validation	NOUN
admet-923	385	6	using	use	VERB
admet-923	385	7	the	the	DET
admet-923	385	8	optimized	optimize	VERB
admet-923	385	9	kperm	kperm	NOUN
admet-923	385	10	value	value	NOUN
admet-923	385	11	,	,	PUNCT
admet-923	385	12	f	f	PROPN
admet-923	385	13	is	be	AUX
admet-923	385	14	calculated	calculate	VERB
admet-923	385	15	as	as	ADP
admet-923	385	16	,	,	PUNCT
admet-923	385	17	this	this	PRON
admet-923	385	18	predicted	predict	VERB
admet-923	385	19	f	f	PROPN
admet-923	385	20	value	value	NOUN
admet-923	385	21	perfectly	perfectly	ADV
admet-923	385	22	matches	match	VERB
admet-923	385	23	the	the	DET
admet-923	385	24	clinical	clinical	ADJ
admet-923	385	25	f	f	PROPN
admet-923	385	26	data	datum	NOUN
admet-923	385	27	(=	(=	NOUN
admet-923	385	28	0.30	0.30	NUM
admet-923	385	29	)	)	PUNCT
admet-923	385	30	.	.	PUNCT
admet-923	386	1	this	this	DET
admet-923	386	2	kperm	kperm	NOUN
admet-923	386	3	value	value	NOUN
admet-923	386	4	is	be	AUX
admet-923	386	5	additionally	additionally	ADV
admet-923	386	6	𝐹	𝐹	PROPN
admet-923	386	7	=	=	NOUN
admet-923	386	8	0.3	0.3	NUM
admet-923	386	9	×	×	NOUN
admet-923	386	10	0.1	0.1	NUM
admet-923	386	11	×	×	NOUN
admet-923	386	12	1000	1000	NUM
admet-923	386	13	×	×	NOUN
admet-923	386	14	3.5	3.5	NUM
admet-923	386	15	350	350	NUM
admet-923	386	16	=	=	SYM
admet-923	386	17	0.30	0.30	NUM
admet-923	386	18	admet	admet	PROPN
admet-923	386	19	&	&	CCONJ
admet-923	386	20	dmpk	dmpk	PROPN
admet-923	386	21	9(2	9(2	NUM
admet-923	386	22	)	)	PUNCT
admet-923	386	23	(	(	PUNCT
admet-923	386	24	2021	2021	NUM
admet-923	386	25	)	)	PUNCT
admet-923	386	26	75	75	NUM
admet-923	386	27	-	-	SYM
admet-923	386	28	109	109	NUM
admet-923	386	29	lost	lose	VERB
admet-923	386	30	in	in	ADP
admet-923	386	31	modelling	modelling	NOUN
admet-923	386	32	and	and	CCONJ
admet-923	386	33	simulation	simulation	NOUN
admet-923	386	34	?	?	PUNCT
admet-923	387	1	doi	doi	NOUN
admet-923	387	2	:	:	PUNCT
admet-923	387	3	https:/doi.org/10.5599	https:/doi.org/10.5599	PROPN
admet-923	387	4	/	/	SYM
admet-923	387	5	admet.923	admet.923	PROPN
admet-923	387	6	89	89	NUM
admet-923	387	7	validated	validate	VERB
admet-923	387	8	using	use	VERB
admet-923	387	9	the	the	DET
admet-923	387	10	independent	independent	ADJ
admet-923	387	11	clinical	clinical	ADJ
admet-923	387	12	f	f	PROPN
admet-923	387	13	data	datum	NOUN
admet-923	387	14	in	in	ADP
admet-923	387	15	the	the	DET
admet-923	387	16	fasted	fasted	ADJ
admet-923	387	17	state	state	NOUN
admet-923	387	18	.	.	PUNCT
admet-923	388	1	step	step	NOUN
admet-923	388	2	5	5	NUM
admet-923	388	3	:	:	PUNCT
admet-923	388	4	prediction	prediction	NOUN
admet-923	388	5	the	the	DET
admet-923	388	6	optimized	optimize	VERB
admet-923	388	7	kperm	kperm	NOUN
admet-923	388	8	value	value	NOUN
admet-923	388	9	is	be	AUX
admet-923	388	10	then	then	ADV
admet-923	388	11	used	use	VERB
admet-923	388	12	to	to	PART
admet-923	388	13	predict	predict	VERB
admet-923	388	14	f	f	PROPN
admet-923	388	15	in	in	ADP
admet-923	388	16	the	the	DET
admet-923	388	17	fed	fed	PROPN
admet-923	388	18	state	state	NOUN
admet-923	388	19	.	.	PUNCT
admet-923	389	1	using	use	VERB
admet-923	389	2	the	the	DET
admet-923	389	3	solubility	solubility	NOUN
admet-923	389	4	in	in	ADP
admet-923	389	5	fessif	fessif	NOUN
admet-923	389	6	(	(	PUNCT
admet-923	389	7	0.2	0.2	NUM
admet-923	389	8	mg	mg	NUM
admet-923	389	9	/	/	SYM
admet-923	389	10	ml	ml	NOUN
admet-923	389	11	)	)	PUNCT
admet-923	389	12	,	,	PUNCT
admet-923	389	13	fa	fa	PROPN
admet-923	389	14	is	be	AUX
admet-923	389	15	calculated	calculate	VERB
admet-923	389	16	as	as	ADP
admet-923	389	17	therefore	therefore	ADV
admet-923	389	18	,	,	PUNCT
admet-923	389	19	auc	auc	NOUN
admet-923	389	20	is	be	AUX
admet-923	389	21	predicted	predict	VERB
admet-923	389	22	to	to	PART
admet-923	389	23	increase	increase	VERB
admet-923	389	24	twofold	twofold	ADV
admet-923	389	25	in	in	ADP
admet-923	389	26	the	the	DET
admet-923	389	27	fed	fed	PROPN
admet-923	389	28	state	state	NOUN
admet-923	389	29	.	.	PUNCT
admet-923	390	1	checkpoint	checkpoint	NOUN
admet-923	390	2	1	1	NUM
admet-923	390	3	:	:	PUNCT
admet-923	390	4	hidden	hidden	ADJ
admet-923	390	5	“	"	PUNCT
admet-923	390	6	bottom	bottom	ADJ
admet-923	390	7	-	-	PUNCT
admet-923	390	8	up	up	ADP
admet-923	390	9	”	"	PUNCT
admet-923	390	10	prediction	prediction	NOUN
admet-923	390	11	usually	usually	ADV
admet-923	390	12	,	,	PUNCT
admet-923	390	13	we	we	PRON
admet-923	390	14	start	start	VERB
admet-923	390	15	a	a	DET
admet-923	390	16	prediction	prediction	NOUN
admet-923	390	17	study	study	NOUN
admet-923	390	18	with	with	ADP
admet-923	390	19	a	a	DET
admet-923	390	20	“	"	PUNCT
admet-923	390	21	bottom	bottom	ADJ
admet-923	390	22	-	-	PUNCT
admet-923	390	23	up	up	NOUN
admet-923	390	24	”	"	PUNCT
admet-923	390	25	approach	approach	NOUN
admet-923	390	26	at	at	ADP
admet-923	390	27	a	a	DET
admet-923	390	28	preclinical	preclinical	ADJ
admet-923	390	29	stage	stage	NOUN
admet-923	390	30	(	(	PUNCT
admet-923	390	31	section	section	NOUN
admet-923	390	32	1.3	1.3	NUM
admet-923	390	33	)	)	PUNCT
admet-923	390	34	.	.	PUNCT
admet-923	391	1	the	the	DET
admet-923	391	2	input	input	NOUN
admet-923	391	3	parameters	parameter	NOUN
admet-923	391	4	are	be	AUX
admet-923	391	5	initially	initially	ADV
admet-923	391	6	projected	project	VERB
admet-923	391	7	from	from	ADP
admet-923	391	8	the	the	DET
admet-923	391	9	in	in	X
admet-923	391	10	vitro	vitro	X
admet-923	391	11	data	datum	NOUN
admet-923	391	12	.	.	PUNCT
admet-923	392	1	in	in	ADP
admet-923	392	2	the	the	DET
admet-923	392	3	above	above	ADJ
admet-923	392	4	case	case	NOUN
admet-923	392	5	,	,	PUNCT
admet-923	392	6	the	the	DET
admet-923	392	7	“	"	PUNCT
admet-923	392	8	bottom	bottom	ADJ
admet-923	392	9	-	-	PUNCT
admet-923	392	10	up	up	NOUN
admet-923	392	11	”	"	PUNCT
admet-923	392	12	prediction	prediction	NOUN
admet-923	392	13	resulted	result	VERB
admet-923	392	14	in	in	ADP
admet-923	392	15	a	a	DET
admet-923	392	16	3	3	NUM
admet-923	392	17	-	-	ADJ
admet-923	392	18	fold	fold	ADJ
admet-923	392	19	underestimation	underestimation	NOUN
admet-923	392	20	.	.	PUNCT
admet-923	393	1	kperm	kperm	PROPN
admet-923	393	2	was	be	AUX
admet-923	393	3	increased	increase	VERB
admet-923	393	4	threefold	threefold	ADV
admet-923	393	5	(	(	PUNCT
admet-923	393	6	from	from	ADP
admet-923	393	7	0.1	0.1	NUM
admet-923	393	8	to	to	ADP
admet-923	393	9	0.3	0.3	NUM
admet-923	393	10	)	)	PUNCT
admet-923	393	11	after	after	ADP
admet-923	393	12	parameter	parameter	NOUN
admet-923	393	13	optimization	optimization	NOUN
admet-923	393	14	.	.	PUNCT
admet-923	394	1	this	this	PRON
admet-923	394	2	is	be	AUX
admet-923	394	3	not	not	PART
admet-923	394	4	a	a	DET
admet-923	394	5	subtle	subtle	ADJ
admet-923	394	6	adjustment	adjustment	NOUN
admet-923	394	7	.	.	PUNCT
admet-923	395	1	this	this	DET
admet-923	395	2	information	information	NOUN
admet-923	395	3	alerts	alert	VERB
admet-923	395	4	that	that	SCONJ
admet-923	395	5	there	there	PRON
admet-923	395	6	is	be	VERB
admet-923	395	7	a	a	DET
admet-923	395	8	marked	mark	VERB
admet-923	395	9	discrepancy	discrepancy	NOUN
admet-923	395	10	between	between	ADP
admet-923	395	11	the	the	DET
admet-923	395	12	kperm	kperm	NOUN
admet-923	395	13	values	value	NOUN
admet-923	395	14	estimated	estimate	VERB
admet-923	395	15	from	from	ADP
admet-923	395	16	the	the	DET
admet-923	395	17	caco-2	caco-2	NUM
admet-923	395	18	data	datum	NOUN
admet-923	395	19	and	and	CCONJ
admet-923	395	20	back	back	ADV
admet-923	395	21	-	-	PUNCT
admet-923	395	22	calculated	calculate	VERB
admet-923	395	23	from	from	ADP
admet-923	395	24	the	the	DET
admet-923	395	25	clinical	clinical	ADJ
admet-923	395	26	f	f	PROPN
admet-923	395	27	data	datum	NOUN
admet-923	395	28	(	(	PUNCT
admet-923	395	29	section	section	NOUN
admet-923	395	30	3.4	3.4	NUM
admet-923	395	31	)	)	PUNCT
admet-923	395	32	.	.	PUNCT
admet-923	396	1	checkpoint	checkpoint	NOUN
admet-923	396	2	2	2	NUM
admet-923	396	3	:	:	PUNCT
admet-923	396	4	subject	subject	NOUN
admet-923	396	5	of	of	ADP
admet-923	396	6	parameter	parameter	NOUN
admet-923	396	7	optimization	optimization	NOUN
admet-923	396	8	the	the	DET
admet-923	396	9	reason	reason	NOUN
admet-923	396	10	for	for	ADP
admet-923	396	11	selecting	select	VERB
admet-923	396	12	kperm	kperm	NOUN
admet-923	396	13	as	as	SCONJ
admet-923	396	14	the	the	DET
admet-923	396	15	subject	subject	NOUN
admet-923	396	16	of	of	ADP
admet-923	396	17	parameter	parameter	NOUN
admet-923	396	18	optimization	optimization	NOUN
admet-923	396	19	is	be	AUX
admet-923	396	20	not	not	PART
admet-923	396	21	clear	clear	ADJ
admet-923	396	22	(	(	PUNCT
admet-923	396	23	sections	section	NOUN
admet-923	396	24	1.2	1.2	NUM
admet-923	396	25	to	to	PART
admet-923	396	26	1.4	1.4	NUM
admet-923	396	27	and	and	CCONJ
admet-923	396	28	3.5	3.5	NUM
admet-923	396	29	to	to	ADP
admet-923	396	30	3.7	3.7	NUM
admet-923	396	31	)	)	PUNCT
admet-923	396	32	.	.	PUNCT
admet-923	397	1	checkpoint	checkpoint	NOUN
admet-923	397	2	3	3	NUM
admet-923	397	3	:	:	PUNCT
admet-923	397	4	parameter	parameter	NOUN
admet-923	397	5	identifiability	identifiability	NOUN
admet-923	397	6	eq	eq	ADP
admet-923	397	7	.	.	PROPN
admet-923	397	8	1	1	NUM
admet-923	397	9	suggests	suggest	VERB
admet-923	397	10	that	that	SCONJ
admet-923	397	11	the	the	DET
admet-923	397	12	kperm	kperm	NOUN
admet-923	397	13	value	value	NOUN
admet-923	397	14	is	be	AUX
admet-923	397	15	not	not	PART
admet-923	397	16	identifiable	identifiable	ADJ
admet-923	397	17	from	from	ADP
admet-923	397	18	the	the	DET
admet-923	397	19	provided	provide	VERB
admet-923	397	20	data	datum	NOUN
admet-923	397	21	(	(	PUNCT
admet-923	397	22	f	f	PROPN
admet-923	397	23	,	,	PUNCT
admet-923	397	24	fh	fh	PROPN
admet-923	397	25	,	,	PUNCT
admet-923	397	26	dose	dose	PROPN
admet-923	397	27	,	,	PUNCT
admet-923	397	28	s	s	PROPN
admet-923	397	29	,	,	PUNCT
admet-923	397	30	vsi	vsi	PROPN
admet-923	397	31	,	,	PUNCT
admet-923	397	32	and	and	CCONJ
admet-923	397	33	tsi	tsi	PROPN
admet-923	397	34	)	)	PUNCT
admet-923	397	35	.	.	PUNCT
admet-923	398	1	fg	fg	PROPN
admet-923	398	2	must	must	AUX
admet-923	398	3	be	be	AUX
admet-923	398	4	separately	separately	ADV
admet-923	398	5	fixed	fix	VERB
admet-923	398	6	(	(	PUNCT
admet-923	398	7	section	section	NOUN
admet-923	398	8	3.8	3.8	NUM
admet-923	398	9	(	(	PUNCT
admet-923	398	10	v	v	NOUN
admet-923	398	11	)	)	PUNCT
admet-923	398	12	)	)	PUNCT
admet-923	398	13	.	.	PUNCT
admet-923	399	1	in	in	ADP
admet-923	399	2	the	the	DET
admet-923	399	3	above	above	ADJ
admet-923	399	4	calculation	calculation	NOUN
admet-923	399	5	,	,	PUNCT
admet-923	399	6	fg	fg	PROPN
admet-923	399	7	was	be	AUX
admet-923	399	8	unknowingly	unknowingly	ADV
admet-923	399	9	assumed	assume	VERB
admet-923	399	10	to	to	PART
admet-923	399	11	be	be	AUX
admet-923	399	12	1	1	NUM
admet-923	399	13	(	(	PUNCT
admet-923	399	14	section	section	NOUN
admet-923	399	15	1.2	1.2	NUM
admet-923	399	16	to	to	PART
admet-923	399	17	1.4	1.4	NUM
admet-923	399	18	)	)	PUNCT
admet-923	399	19	.	.	PUNCT
admet-923	400	1	checkpoint	checkpoint	NOUN
admet-923	400	2	4	4	NUM
admet-923	400	3	:	:	PUNCT
admet-923	400	4	hidden	hide	VERB
admet-923	400	5	errors	error	NOUN
admet-923	400	6	the	the	DET
admet-923	400	7	intestinal	intestinal	ADJ
admet-923	400	8	fluid	fluid	NOUN
admet-923	400	9	volume	volume	NOUN
admet-923	400	10	of	of	ADP
admet-923	400	11	1000	1000	NUM
admet-923	400	12	ml	ml	NOUN
admet-923	400	13	is	be	AUX
admet-923	400	14	significantly	significantly	ADV
admet-923	400	15	greater	great	ADJ
admet-923	400	16	than	than	ADP
admet-923	400	17	the	the	DET
admet-923	400	18	current	current	ADJ
admet-923	400	19	best	good	ADJ
admet-923	400	20	estimate	estimate	NOUN
admet-923	400	21	(	(	PUNCT
admet-923	400	22	most	most	ADV
admet-923	400	23	probably	probably	ADV
admet-923	400	24	<	<	X
admet-923	400	25	150	150	NUM
admet-923	400	26	ml	ml	NOUN
admet-923	400	27	)	)	PUNCT
admet-923	400	28	(	(	PUNCT
admet-923	400	29	in	in	ADP
admet-923	400	30	the	the	DET
admet-923	400	31	discussion	discussion	NOUN
admet-923	400	32	below	below	ADV
admet-923	400	33	,	,	PUNCT
admet-923	400	34	we	we	PRON
admet-923	400	35	assume	assume	VERB
admet-923	400	36	that	that	SCONJ
admet-923	400	37	100	100	NUM
admet-923	400	38	ml	ml	NOUN
admet-923	400	39	is	be	AUX
admet-923	400	40	realistic	realistic	ADJ
admet-923	400	41	for	for	ADP
admet-923	400	42	the	the	DET
admet-923	400	43	convenience	convenience	NOUN
admet-923	400	44	of	of	ADP
admet-923	400	45	discussion	discussion	NOUN
admet-923	400	46	)	)	PUNCT
admet-923	401	1	[	[	X
admet-923	401	2	26–29	26–29	NOUN
admet-923	401	3	]	]	X
admet-923	401	4	.	.	PUNCT
admet-923	402	1	the	the	DET
admet-923	402	2	optimized	optimize	VERB
admet-923	402	3	kperm	kperm	NOUN
admet-923	402	4	value	value	NOUN
admet-923	402	5	carries	carry	VERB
admet-923	402	6	the	the	DET
admet-923	402	7	error	error	NOUN
admet-923	402	8	in	in	ADP
admet-923	402	9	the	the	DET
admet-923	402	10	intestinal	intestinal	ADJ
admet-923	402	11	fluid	fluid	NOUN
admet-923	402	12	volume	volume	NOUN
admet-923	402	13	(	(	PUNCT
admet-923	402	14	e.g.	e.g.	ADV
admet-923	402	15	,	,	PUNCT
admet-923	402	16	1000	1000	NUM
admet-923	402	17	ml	ml	NOUN
admet-923	402	18	vs	vs	ADP
admet-923	402	19	100	100	NUM
admet-923	402	20	ml	ml	NOUN
admet-923	402	21	)	)	PUNCT
admet-923	402	22	.	.	PUNCT
admet-923	403	1	with	with	ADP
admet-923	403	2	a	a	DET
admet-923	403	3	more	more	ADV
admet-923	403	4	realistic	realistic	ADJ
admet-923	403	5	intestinal	intestinal	ADJ
admet-923	403	6	fluid	fluid	NOUN
admet-923	403	7	volume	volume	NOUN
admet-923	403	8	of	of	ADP
admet-923	403	9	100	100	NUM
admet-923	403	10	ml	ml	NOUN
admet-923	403	11	,	,	PUNCT
admet-923	403	12	the	the	DET
admet-923	403	13	kperm	kperm	NOUN
admet-923	403	14	value	value	NOUN
admet-923	403	15	is	be	AUX
admet-923	403	16	back	back	ADV
admet-923	403	17	-	-	PUNCT
admet-923	403	18	calculated	calculate	VERB
admet-923	403	19	to	to	PART
admet-923	403	20	be	be	AUX
admet-923	403	21	3.0	3.0	NUM
admet-923	403	22	h-1	h-1	NOUN
admet-923	403	23	,	,	PUNCT
admet-923	403	24	ten	ten	NUM
admet-923	403	25	-	-	NOUN
admet-923	403	26	fold	fold	VERB
admet-923	403	27	higher	high	ADJ
admet-923	403	28	than	than	ADP
admet-923	403	29	0.3	0.3	NUM
admet-923	403	30	h-1	h-1	NOUN
admet-923	403	31	.	.	PUNCT
admet-923	404	1	this	this	PRON
admet-923	404	2	could	could	AUX
admet-923	404	3	cause	cause	VERB
admet-923	404	4	a	a	DET
admet-923	404	5	misunderstanding	misunderstanding	NOUN
admet-923	404	6	of	of	ADP
admet-923	404	7	the	the	DET
admet-923	404	8	rate	rate	NOUN
admet-923	404	9	-	-	PUNCT
admet-923	404	10	limiting	limit	VERB
admet-923	404	11	step	step	NOUN
admet-923	404	12	for	for	ADP
admet-923	404	13	membrane	membrane	NOUN
admet-923	404	14	permeation	permeation	NOUN
admet-923	404	15	(	(	PUNCT
admet-923	404	16	section	section	NOUN
admet-923	404	17	1.4	1.4	NUM
admet-923	404	18	)	)	PUNCT
admet-923	404	19	.	.	PUNCT
admet-923	405	1	checkpoint	checkpoint	NOUN
admet-923	405	2	5	5	NUM
admet-923	405	3	:	:	PUNCT
admet-923	405	4	variation	variation	NOUN
admet-923	405	5	of	of	ADP
admet-923	405	6	clinical	clinical	ADJ
admet-923	405	7	data	datum	NOUN
admet-923	405	8	considering	consider	VERB
admet-923	405	9	that	that	SCONJ
admet-923	405	10	cv%	cv%	PROPN
admet-923	405	11	of	of	ADP
admet-923	405	12	f	f	PROPN
admet-923	405	13	is	be	AUX
admet-923	405	14	50	50	NUM
admet-923	405	15	%	%	NOUN
admet-923	405	16	,	,	PUNCT
admet-923	405	17	it	it	PRON
admet-923	405	18	is	be	AUX
admet-923	405	19	not	not	PART
admet-923	405	20	possible	possible	ADJ
admet-923	405	21	to	to	PART
admet-923	405	22	back	back	NOUN
admet-923	405	23	-	-	PUNCT
admet-923	405	24	calculate	calculate	VERB
admet-923	405	25	the	the	DET
admet-923	405	26	kperm	kperm	NOUN
admet-923	405	27	value	value	NOUN
admet-923	405	28	within	within	ADP
admet-923	405	29	a	a	DET
admet-923	405	30	good	good	ADJ
admet-923	405	31	confidence	confidence	NOUN
admet-923	405	32	interval	interval	NOUN
admet-923	405	33	.	.	PUNCT
admet-923	406	1	checkpoint	checkpoint	NOUN
admet-923	406	2	6	6	NUM
admet-923	406	3	:	:	PUNCT
admet-923	406	4	constancy	constancy	NOUN
admet-923	406	5	of	of	ADP
admet-923	406	6	optimized	optimize	VERB
admet-923	406	7	parameter	parameter	NOUN
admet-923	406	8	it	it	PRON
admet-923	406	9	was	be	AUX
admet-923	406	10	implicitly	implicitly	ADV
admet-923	406	11	assumed	assume	VERB
admet-923	406	12	that	that	SCONJ
admet-923	406	13	the	the	DET
admet-923	406	14	kperm	kperm	NOUN
admet-923	406	15	values	value	NOUN
admet-923	406	16	in	in	ADP
admet-923	406	17	the	the	DET
admet-923	406	18	fasted	fast	VERB
admet-923	406	19	and	and	CCONJ
admet-923	406	20	fed	fed	PROPN
admet-923	406	21	states	state	NOUN
admet-923	406	22	are	be	AUX
admet-923	406	23	the	the	DET
admet-923	406	24	same	same	ADJ
admet-923	406	25	.	.	PUNCT
admet-923	407	1	however	however	ADV
admet-923	407	2	,	,	PUNCT
admet-923	407	3	it	it	PRON
admet-923	407	4	is	be	AUX
admet-923	407	5	well	well	ADV
admet-923	407	6	known	know	VERB
admet-923	407	7	that	that	SCONJ
admet-923	407	8	bile	bile	NOUN
admet-923	407	9	micelle	micelle	NOUN
admet-923	407	10	binding	bind	VERB
admet-923	407	11	reduces	reduce	VERB
admet-923	407	12	the	the	DET
admet-923	407	13	free	free	ADJ
admet-923	407	14	fraction	fraction	NOUN
admet-923	407	15	,	,	PUNCT
admet-923	407	16	the	the	DET
admet-923	407	17	effective	effective	ADJ
admet-923	407	18	diffusion	diffusion	NOUN
admet-923	407	19	coefficient	coefficient	NOUN
admet-923	407	20	,	,	PUNCT
admet-923	407	21	and	and	CCONJ
admet-923	407	22	consequently	consequently	ADV
admet-923	407	23	peff	peff	PROPN
admet-923	407	24	and	and	CCONJ
admet-923	407	25	kperm	kperm	NOUN
admet-923	407	26	(	(	PUNCT
admet-923	407	27	section	section	NOUN
admet-923	407	28	2.7	2.7	NUM
admet-923	407	29	)	)	PUNCT
admet-923	408	1	[	[	X
admet-923	408	2	51,91,92,94,147,148	51,91,92,94,147,148	NUM
admet-923	408	3	]	]	PUNCT
admet-923	408	4	.	.	PUNCT
admet-923	409	1	𝐹	𝐹	PROPN
admet-923	409	2	=	=	NOUN
admet-923	410	1	0.3	0.3	NUM
admet-923	410	2	×	×	NOUN
admet-923	410	3	0.2	0.2	NUM
admet-923	410	4	×	×	NOUN
admet-923	410	5	1000	1000	NUM
admet-923	410	6	×	×	NOUN
admet-923	410	7	3.5	3.5	NUM
admet-923	410	8	350	350	NUM
admet-923	410	9	=	=	SYM
admet-923	410	10	0.60	0.60	NUM
admet-923	410	11	𝐹	𝐹	PROPN
admet-923	410	12	=	=	NOUN
admet-923	410	13	0.1	0.1	NUM
admet-923	410	14	×	×	NOUN
admet-923	410	15	0.1	0.1	NUM
admet-923	410	16	×	×	NOUN
admet-923	410	17	1000	1000	NUM
admet-923	410	18	×	×	NOUN
admet-923	410	19	3.5	3.5	NUM
admet-923	410	20	350	350	NUM
admet-923	410	21	=	=	SYM
admet-923	410	22	0.10	0.10	NUM
admet-923	410	23	https://doi.org/10.5599/admet.923	https://doi.org/10.5599/admet.923	NOUN
admet-923	410	24	kiyohiko	kiyohiko	NOUN
admet-923	410	25	sugano	sugano	PROPN
admet-923	410	26	admet	admet	PROPN
admet-923	410	27	&	&	CCONJ
admet-923	410	28	dmpk	dmpk	PROPN
admet-923	410	29	9(2	9(2	NUM
admet-923	410	30	)	)	PUNCT
admet-923	410	31	(	(	PUNCT
admet-923	410	32	2021	2021	NUM
admet-923	410	33	)	)	PUNCT
admet-923	410	34	75	75	NUM
admet-923	410	35	-	-	SYM
admet-923	410	36	109	109	NUM
admet-923	410	37	90	90	NUM
admet-923	410	38	checkpoint	checkpoint	NOUN
admet-923	410	39	7	7	NUM
admet-923	410	40	:	:	PUNCT
admet-923	410	41	model	model	NOUN
admet-923	410	42	validation	validation	NOUN
admet-923	410	43	the	the	DET
admet-923	410	44	predictive	predictive	ADJ
admet-923	410	45	power	power	NOUN
admet-923	410	46	of	of	ADP
admet-923	410	47	a	a	DET
admet-923	410	48	model	model	NOUN
admet-923	410	49	can	can	AUX
admet-923	410	50	not	not	PART
admet-923	410	51	be	be	AUX
admet-923	410	52	validated	validate	VERB
admet-923	410	53	by	by	ADP
admet-923	410	54	the	the	DET
admet-923	410	55	same	same	ADJ
admet-923	410	56	data	datum	NOUN
admet-923	410	57	used	use	VERB
admet-923	410	58	for	for	ADP
admet-923	410	59	parameter	parameter	NOUN
admet-923	410	60	backcalculation	backcalculation	NOUN
admet-923	410	61	(	(	PUNCT
admet-923	410	62	section	section	NOUN
admet-923	410	63	3.11	3.11	NUM
admet-923	410	64	)	)	PUNCT
admet-923	410	65	.	.	PUNCT
admet-923	411	1	checkpoint	checkpoint	NOUN
admet-923	411	2	8	8	NUM
admet-923	411	3	:	:	PUNCT
admet-923	411	4	prediction	prediction	NOUN
admet-923	411	5	after	after	ADP
admet-923	411	6	parameter	parameter	PROPN
admet-923	411	7	optimization	optimization	NOUN
admet-923	411	8	,	,	PUNCT
admet-923	411	9	the	the	DET
admet-923	411	10	predictive	predictive	ADJ
admet-923	411	11	range	range	NOUN
admet-923	411	12	of	of	ADP
admet-923	411	13	the	the	DET
admet-923	411	14	optimized	optimize	VERB
admet-923	411	15	model	model	NOUN
admet-923	411	16	is	be	AUX
admet-923	411	17	limited	limit	VERB
admet-923	411	18	to	to	ADP
admet-923	411	19	the	the	DET
admet-923	411	20	parameter	parameter	NOUN
admet-923	411	21	space	space	NOUN
admet-923	411	22	of	of	ADP
admet-923	411	23	the	the	DET
admet-923	411	24	clinical	clinical	ADJ
admet-923	411	25	data	datum	NOUN
admet-923	411	26	that	that	PRON
admet-923	411	27	is	be	AUX
admet-923	411	28	used	use	VERB
admet-923	411	29	for	for	ADP
admet-923	411	30	model	model	NOUN
admet-923	411	31	development	development	NOUN
admet-923	411	32	(	(	PUNCT
admet-923	411	33	limited	limit	VERB
admet-923	411	34	to	to	ADP
admet-923	411	35	interpolation	interpolation	NOUN
admet-923	411	36	with	with	ADP
admet-923	411	37	some	some	DET
admet-923	411	38	exceptions	exception	NOUN
admet-923	411	39	)	)	PUNCT
admet-923	411	40	.	.	PUNCT
admet-923	412	1	in	in	ADP
admet-923	412	2	the	the	DET
admet-923	412	3	above	above	ADJ
admet-923	412	4	example	example	NOUN
admet-923	412	5	,	,	PUNCT
admet-923	412	6	a	a	DET
admet-923	412	7	simple	simple	ADJ
admet-923	412	8	model	model	NOUN
admet-923	412	9	(	(	PUNCT
admet-923	412	10	eq	eq	NOUN
admet-923	412	11	.	.	NOUN
admet-923	412	12	1	1	NUM
admet-923	412	13	)	)	PUNCT
admet-923	412	14	was	be	AUX
admet-923	412	15	used	use	VERB
admet-923	412	16	for	for	ADP
admet-923	412	17	convenience	convenience	NOUN
admet-923	412	18	to	to	PART
admet-923	412	19	illustrate	illustrate	VERB
admet-923	412	20	the	the	DET
admet-923	412	21	middle	middle	ADJ
admet-923	412	22	-	-	PUNCT
admet-923	412	23	out	out	ADP
admet-923	412	24	approach	approach	NOUN
admet-923	412	25	.	.	PUNCT
admet-923	413	1	in	in	ADP
admet-923	413	2	complicated	complicated	ADJ
admet-923	413	3	pbpk	pbpk	NOUN
admet-923	413	4	modelling	modelling	NOUN
admet-923	413	5	,	,	PUNCT
admet-923	413	6	these	these	DET
admet-923	413	7	checkpoints	checkpoint	NOUN
admet-923	413	8	are	be	AUX
admet-923	413	9	not	not	PART
admet-923	413	10	so	so	ADV
admet-923	413	11	easy	easy	ADJ
admet-923	413	12	to	to	PART
admet-923	413	13	recognize	recognize	VERB
admet-923	413	14	.	.	PUNCT
admet-923	414	1	however	however	ADV
admet-923	414	2	,	,	PUNCT
admet-923	414	3	the	the	DET
admet-923	414	4	mathematical	mathematical	ADJ
admet-923	414	5	principle	principle	NOUN
admet-923	414	6	remains	remain	VERB
admet-923	414	7	the	the	DET
admet-923	414	8	same	same	ADJ
admet-923	414	9	.	.	PUNCT
admet-923	415	1	3.4	3.4	NUM
admet-923	415	2	.	.	PUNCT
admet-923	416	1	when	when	SCONJ
admet-923	416	2	is	be	AUX
admet-923	416	3	a	a	DET
admet-923	416	4	local	local	ADJ
admet-923	416	5	middle	middle	ADJ
admet-923	416	6	-	-	PUNCT
admet-923	416	7	out	out	ADP
admet-923	416	8	approach	approach	NOUN
admet-923	416	9	required	require	VERB
admet-923	416	10	?	?	PUNCT
admet-923	417	1	a	a	DET
admet-923	417	2	local	local	ADJ
admet-923	417	3	middle	middle	ADJ
admet-923	417	4	-	-	PUNCT
admet-923	417	5	out	out	ADP
admet-923	417	6	approach	approach	NOUN
admet-923	417	7	is	be	AUX
admet-923	417	8	required	require	VERB
admet-923	417	9	when	when	SCONJ
admet-923	417	10	a	a	DET
admet-923	417	11	bottom	bottom	ADJ
admet-923	417	12	-	-	PUNCT
admet-923	417	13	up	up	ADP
admet-923	417	14	prediction	prediction	NOUN
admet-923	417	15	is	be	AUX
admet-923	417	16	not	not	PART
admet-923	417	17	satisfactory	satisfactory	ADJ
admet-923	417	18	for	for	ADP
admet-923	417	19	the	the	DET
admet-923	417	20	contest	contest	NOUN
admet-923	417	21	of	of	ADP
admet-923	417	22	use	use	NOUN
admet-923	417	23	(	(	PUNCT
admet-923	417	24	section	section	NOUN
admet-923	417	25	1.3	1.3	NUM
admet-923	417	26	,	,	PUNCT
admet-923	417	27	figure	figure	NOUN
admet-923	417	28	1	1	NUM
admet-923	417	29	)	)	PUNCT
admet-923	417	30	.	.	PUNCT
admet-923	418	1	the	the	DET
admet-923	418	2	widespread	widespread	ADJ
admet-923	418	3	use	use	NOUN
admet-923	418	4	of	of	ADP
admet-923	418	5	a	a	DET
admet-923	418	6	local	local	ADJ
admet-923	418	7	middle	middle	ADJ
admet-923	418	8	-	-	PUNCT
admet-923	418	9	out	out	ADP
admet-923	418	10	approach	approach	NOUN
admet-923	418	11	is	be	AUX
admet-923	418	12	consistent	consistent	ADJ
admet-923	418	13	with	with	ADP
admet-923	418	14	the	the	DET
admet-923	418	15	results	result	NOUN
admet-923	418	16	of	of	ADP
admet-923	418	17	systematic	systematic	ADJ
admet-923	418	18	evaluation	evaluation	NOUN
admet-923	418	19	suggesting	suggest	VERB
admet-923	418	20	that	that	SCONJ
admet-923	418	21	current	current	ADJ
admet-923	418	22	bottom	bottom	NOUN
admet-923	418	23	-	-	PUNCT
admet-923	418	24	up	up	NOUN
admet-923	418	25	oa	oa	X
admet-923	418	26	pbpk	pbpk	NOUN
admet-923	418	27	models	model	NOUN
admet-923	418	28	need	need	VERB
admet-923	418	29	significant	significant	ADJ
admet-923	418	30	improvement	improvement	NOUN
admet-923	418	31	(	(	PUNCT
admet-923	418	32	introduction	introduction	NOUN
admet-923	418	33	section	section	NOUN
admet-923	418	34	)	)	PUNCT
admet-923	418	35	.	.	PUNCT
admet-923	419	1	discrepancies	discrepancy	NOUN
admet-923	419	2	between	between	ADP
admet-923	419	3	bottom	bottom	ADJ
admet-923	419	4	-	-	PUNCT
admet-923	419	5	up	up	ADP
admet-923	419	6	predictions	prediction	NOUN
admet-923	419	7	and	and	CCONJ
admet-923	419	8	clinical	clinical	ADJ
admet-923	419	9	observations	observation	NOUN
admet-923	419	10	may	may	AUX
admet-923	419	11	suggest	suggest	VERB
admet-923	419	12	opportunities	opportunity	NOUN
admet-923	419	13	to	to	PART
admet-923	419	14	uncover	uncover	VERB
admet-923	419	15	unidentified	unidentified	ADJ
admet-923	419	16	mechanisms	mechanism	NOUN
admet-923	419	17	or	or	CCONJ
admet-923	419	18	to	to	PART
admet-923	419	19	improve	improve	VERB
admet-923	419	20	the	the	DET
admet-923	419	21	equations	equation	NOUN
admet-923	419	22	and	and	CCONJ
admet-923	419	23	parameters	parameter	NOUN
admet-923	419	24	of	of	ADP
admet-923	419	25	the	the	DET
admet-923	419	26	model	model	NOUN
admet-923	419	27	(	(	PUNCT
admet-923	419	28	sections	section	NOUN
admet-923	419	29	1.3	1.3	NUM
admet-923	419	30	,	,	PUNCT
admet-923	419	31	3.3	3.3	NUM
admet-923	419	32	checkpoint	checkpoint	NOUN
admet-923	419	33	4	4	NUM
admet-923	419	34	)	)	PUNCT
admet-923	419	35	.	.	PUNCT
admet-923	420	1	before	before	ADP
admet-923	420	2	parameter	parameter	PROPN
admet-923	420	3	back	back	NOUN
admet-923	420	4	-	-	PUNCT
admet-923	420	5	calculation	calculation	NOUN
admet-923	420	6	,	,	PUNCT
admet-923	420	7	the	the	DET
admet-923	420	8	reason	reason	NOUN
admet-923	420	9	for	for	ADP
admet-923	420	10	the	the	DET
admet-923	420	11	discrepancy	discrepancy	NOUN
admet-923	420	12	should	should	AUX
admet-923	420	13	be	be	AUX
admet-923	420	14	thoroughly	thoroughly	ADV
admet-923	420	15	explored	explore	VERB
admet-923	420	16	(	(	PUNCT
admet-923	420	17	sections	section	NOUN
admet-923	420	18	1.4	1.4	NUM
admet-923	420	19	and	and	CCONJ
admet-923	420	20	2.7	2.7	NUM
admet-923	420	21	)	)	PUNCT
admet-923	420	22	.	.	PUNCT
admet-923	421	1	3.5	3.5	NUM
admet-923	421	2	.	.	PUNCT
admet-923	422	1	how	how	SCONJ
admet-923	422	2	to	to	PART
admet-923	422	3	diagnose	diagnose	VERB
admet-923	422	4	parameter	parameter	NOUN
admet-923	422	5	identifiability	identifiability	NOUN
admet-923	422	6	in	in	ADP
admet-923	422	7	oa	oa	ADP
admet-923	422	8	pbpk	pbpk	NOUN
admet-923	422	9	modelling	modelling	NOUN
admet-923	422	10	in	in	ADP
admet-923	422	11	the	the	DET
admet-923	422	12	literature	literature	NOUN
admet-923	422	13	,	,	PUNCT
admet-923	422	14	peff	peff	PROPN
admet-923	422	15	has	have	AUX
admet-923	422	16	often	often	ADV
admet-923	422	17	been	be	AUX
admet-923	422	18	the	the	DET
admet-923	422	19	subject	subject	NOUN
admet-923	422	20	of	of	ADP
admet-923	422	21	back	back	NOUN
admet-923	422	22	-	-	PUNCT
admet-923	422	23	calculation	calculation	NOUN
admet-923	422	24	.	.	PUNCT
admet-923	423	1	therefore	therefore	ADV
admet-923	423	2	,	,	PUNCT
admet-923	423	3	the	the	DET
admet-923	423	4	identifiability	identifiability	NOUN
admet-923	423	5	of	of	ADP
admet-923	423	6	peff	peff	NOUN
admet-923	423	7	is	be	AUX
admet-923	423	8	discussed	discuss	VERB
admet-923	423	9	as	as	ADP
admet-923	423	10	an	an	DET
admet-923	423	11	example	example	NOUN
admet-923	423	12	below	below	ADV
admet-923	423	13	.	.	PUNCT
admet-923	424	1	simple	simple	ADJ
admet-923	424	2	analytical	analytical	ADJ
admet-923	424	3	solutions	solution	NOUN
admet-923	424	4	are	be	AUX
admet-923	424	5	useful	useful	ADJ
admet-923	424	6	for	for	ADP
admet-923	424	7	diagnosing	diagnose	VERB
admet-923	424	8	the	the	DET
admet-923	424	9	parameter	parameter	NOUN
admet-923	424	10	identifiability	identifiability	NOUN
admet-923	424	11	(	(	PUNCT
admet-923	424	12	section	section	NOUN
admet-923	424	13	2.2	2.2	NUM
admet-923	424	14	)	)	PUNCT
admet-923	424	15	.	.	PUNCT
admet-923	425	1	the	the	DET
admet-923	425	2	fa	fa	PROPN
admet-923	425	3	equation	equation	NOUN
admet-923	425	4	represents	represent	VERB
admet-923	425	5	the	the	DET
admet-923	425	6	relationship	relationship	NOUN
admet-923	425	7	between	between	ADP
admet-923	425	8	the	the	DET
admet-923	425	9	solubility	solubility	NOUN
admet-923	425	10	,	,	PUNCT
admet-923	425	11	dissolution	dissolution	NOUN
admet-923	425	12	rate	rate	NOUN
admet-923	425	13	,	,	PUNCT
admet-923	425	14	and	and	CCONJ
admet-923	425	15	permeation	permeation	NOUN
admet-923	425	16	of	of	ADP
admet-923	425	17	a	a	DET
admet-923	425	18	drug	drug	NOUN
admet-923	425	19	to	to	ADP
admet-923	425	20	fa	fa	PROPN
admet-923	426	1	[	[	X
admet-923	426	2	5,35,149	5,35,149	NUM
admet-923	426	3	]	]	X
admet-923	426	4	:	:	PUNCT
admet-923	426	5	a	a	DET
admet-923	426	6	1	1	NUM
admet-923	426	7	1	1	NUM
admet-923	426	8	exp	exp	NOUN
admet-923	426	9	1	1	NUM
admet-923	426	10	f	f	NOUN
admet-923	426	11	do	do	AUX
admet-923	426	12	dn	dn	PROPN
admet-923	426	13	pn	pn	PROPN
admet-923	426	14			PROPN
admet-923	426	15			PROPN
admet-923	426	16			PROPN
admet-923	426	17			PROPN
admet-923	427	1			PROPN
admet-923	427	2			PROPN
admet-923	427	3			PROPN
admet-923	427	4			PROPN
admet-923	428	1			PROPN
admet-923	428	2			PROPN
admet-923	429	1			ADJ
admet-923	429	2			NOUN
admet-923	429	3	(	(	PUNCT
admet-923	429	4	2	2	NUM
admet-923	429	5	)	)	PUNCT
admet-923	429	6	where	where	SCONJ
admet-923	429	7	dn	dn	PROPN
admet-923	429	8	is	be	AUX
admet-923	429	9	the	the	DET
admet-923	429	10	product	product	NOUN
admet-923	429	11	of	of	ADP
admet-923	429	12	the	the	DET
admet-923	429	13	dissolution	dissolution	NOUN
admet-923	429	14	rate	rate	NOUN
admet-923	429	15	(	(	PUNCT
admet-923	429	16	kdiss	kdiss	ADJ
admet-923	429	17	)	)	PUNCT
admet-923	429	18	and	and	CCONJ
admet-923	429	19	the	the	DET
admet-923	429	20	intestinal	intestinal	ADJ
admet-923	429	21	transit	transit	NOUN
admet-923	429	22	time	time	NOUN
admet-923	429	23	(	(	PUNCT
admet-923	429	24	dn	dn	NOUN
admet-923	429	25	=	=	PUNCT
admet-923	429	26	kdiss	kdiss	PROPN
admet-923	429	27	×	×	PROPN
admet-923	429	28	tsi	tsi	PROPN
admet-923	429	29	)	)	PUNCT
admet-923	429	30	.	.	PUNCT
admet-923	430	1	when	when	SCONJ
admet-923	430	2	do	do	VERB
admet-923	430	3	<	<	X
admet-923	430	4	1	1	NUM
admet-923	430	5	,	,	PUNCT
admet-923	430	6	set	set	VERB
admet-923	430	7	do	do	NOUN
admet-923	430	8	=	=	SYM
admet-923	430	9	1	1	X
admet-923	430	10	.	.	PUNCT
admet-923	431	1	when	when	SCONJ
admet-923	431	2	the	the	DET
admet-923	431	3	oral	oral	ADJ
admet-923	431	4	absorption	absorption	NOUN
admet-923	431	5	of	of	ADP
admet-923	431	6	a	a	DET
admet-923	431	7	drug	drug	NOUN
admet-923	431	8	is	be	AUX
admet-923	431	9	limited	limit	VERB
admet-923	431	10	by	by	ADP
admet-923	431	11	the	the	DET
admet-923	431	12	dissolution	dissolution	NOUN
admet-923	431	13	rate	rate	NOUN
admet-923	431	14	(	(	PUNCT
admet-923	431	15	dn	dn	NOUN
admet-923	431	16	<	<	X
admet-923	431	17	pn	pn	X
admet-923	431	18	/	/	SYM
admet-923	431	19	do	do	NOUN
admet-923	431	20	)	)	PUNCT
admet-923	431	21	,	,	PUNCT
admet-923	431	22	the	the	DET
admet-923	431	23	permeation	permeation	NOUN
admet-923	431	24	process	process	NOUN
admet-923	431	25	is	be	AUX
admet-923	431	26	statistically	statistically	ADV
admet-923	431	27	non	non	ADJ
admet-923	431	28	-	-	ADJ
admet-923	431	29	identifiable	identifiable	ADJ
admet-923	431	30	from	from	ADP
admet-923	431	31	fa	fa	PROPN
admet-923	431	32	(	(	PUNCT
admet-923	431	33	cf	cf	NOUN
admet-923	431	34	.	.	PUNCT
admet-923	432	1	y	y	PROPN
admet-923	432	2	=	=	SYM
admet-923	432	3	1/	1/	NUM
admet-923	432	4	(	(	PUNCT
admet-923	432	5	x	x	PROPN
admet-923	432	6	+	+	NUM
admet-923	432	7	a	a	X
admet-923	432	8	)	)	PUNCT
admet-923	432	9	)	)	PUNCT
admet-923	432	10	.	.	PUNCT
admet-923	433	1	in	in	ADP
admet-923	433	2	other	other	ADJ
admet-923	433	3	words	word	NOUN
admet-923	433	4	,	,	PUNCT
admet-923	433	5	for	for	SCONJ
admet-923	433	6	peff	peff	PROPN
admet-923	433	7	to	to	PART
admet-923	433	8	be	be	AUX
admet-923	433	9	identifiable	identifiable	ADJ
admet-923	433	10	,	,	PUNCT
admet-923	433	11	the	the	DET
admet-923	433	12	oral	oral	ADJ
admet-923	433	13	absorption	absorption	NOUN
admet-923	433	14	must	must	AUX
admet-923	433	15	be	be	AUX
admet-923	433	16	permeability	permeability	NOUN
admet-923	433	17	or	or	CCONJ
admet-923	433	18	solubility	solubility	NOUN
admet-923	433	19	-	-	PUNCT
admet-923	433	20	permeability	permeability	NOUN
admet-923	433	21	limited	limit	VERB
admet-923	433	22	.	.	PUNCT
admet-923	434	1	in	in	ADP
admet-923	434	2	this	this	DET
admet-923	434	3	case	case	NOUN
admet-923	434	4	,	,	PUNCT
admet-923	434	5	eq	eq	NOUN
admet-923	434	6	.	.	NOUN
admet-923	434	7	2	2	NUM
admet-923	434	8	becomes	become	VERB
admet-923	434	9	:	:	PUNCT
admet-923	434	10	a	a	DET
admet-923	434	11	1	1	NUM
admet-923	434	12	exp	exp	NOUN
admet-923	434	13	pn	pn	PROPN
admet-923	434	14	f	f	PROPN
admet-923	434	15	do	do	VERB
admet-923	434	16			NOUN
admet-923	434	17			PROPN
admet-923	434	18			PROPN
admet-923	434	19			PROPN
admet-923	434	20			PROPN
admet-923	434	21			CCONJ
admet-923	435	1			PROPN
admet-923	435	2			NOUN
admet-923	435	3	(	(	PUNCT
admet-923	435	4	3	3	NUM
admet-923	435	5	)	)	PUNCT
admet-923	435	6	at	at	ADP
admet-923	435	7	pn	pn	PROPN
admet-923	435	8	/	/	SYM
admet-923	435	9	do	do	AUX
admet-923	435	10	>	>	X
admet-923	435	11	0.7	0.7	NUM
admet-923	435	12	,	,	PUNCT
admet-923	435	13	the	the	DET
admet-923	435	14	peff	peff	NOUN
admet-923	435	15	value	value	NOUN
admet-923	435	16	(	(	PUNCT
admet-923	435	17	that	that	PRON
admet-923	435	18	is	be	AUX
admet-923	435	19	in	in	ADP
admet-923	435	20	pn	pn	PROPN
admet-923	435	21	)	)	PUNCT
admet-923	435	22	is	be	AUX
admet-923	435	23	statistically	statistically	ADV
admet-923	435	24	non	non	ADJ
admet-923	435	25	-	-	ADJ
admet-923	435	26	identifiable	identifiable	ADJ
admet-923	435	27	from	from	ADP
admet-923	435	28	clinical	clinical	ADJ
admet-923	435	29	fa	fa	PROPN
admet-923	435	30	data	datum	NOUN
admet-923	435	31	considering	consider	VERB
admet-923	435	32	the	the	DET
admet-923	435	33	variation	variation	NOUN
admet-923	435	34	of	of	ADP
admet-923	435	35	clinical	clinical	ADJ
admet-923	435	36	fa	fa	NOUN
admet-923	435	37	data	datum	NOUN
admet-923	435	38	(	(	PUNCT
admet-923	435	39	cf	cf	NOUN
admet-923	435	40	.	.	PUNCT
admet-923	436	1	y	y	NOUN
admet-923	436	2	=	=	SYM
admet-923	436	3	1	1	NUM
admet-923	436	4	exp(-ax	exp(-ax	NOUN
admet-923	436	5	)	)	PUNCT
admet-923	436	6	,	,	PUNCT
admet-923	436	7	figure	figure	VERB
admet-923	436	8	6	6	NUM
admet-923	436	9	)	)	PUNCT
admet-923	436	10	.	.	PUNCT
admet-923	437	1	at	at	ADP
admet-923	437	2	pn	pn	PROPN
admet-923	437	3	/	/	SYM
admet-923	437	4	do	do	AUX
admet-923	437	5	<	<	X
admet-923	437	6	0.7	0.7	NUM
admet-923	437	7	,	,	PUNCT
admet-923	437	8	eq	eq	NOUN
admet-923	437	9	.	.	NOUN
admet-923	437	10	3	3	NUM
admet-923	437	11	can	can	AUX
admet-923	437	12	be	be	AUX
admet-923	437	13	approximated	approximate	VERB
admet-923	437	14	to	to	ADP
admet-923	437	15	[	[	X
admet-923	437	16	146	146	NUM
admet-923	437	17	]	]	SYM
admet-923	437	18	:	:	PUNCT
admet-923	437	19	admet	admet	PROPN
admet-923	437	20	&	&	CCONJ
admet-923	437	21	dmpk	dmpk	PROPN
admet-923	437	22	9(2	9(2	NUM
admet-923	437	23	)	)	PUNCT
admet-923	437	24	(	(	PUNCT
admet-923	437	25	2021	2021	NUM
admet-923	437	26	)	)	PUNCT
admet-923	437	27	75	75	NUM
admet-923	437	28	-	-	SYM
admet-923	437	29	109	109	NUM
admet-923	437	30	lost	lose	VERB
admet-923	437	31	in	in	ADP
admet-923	437	32	modelling	modelling	NOUN
admet-923	437	33	and	and	CCONJ
admet-923	437	34	simulation	simulation	NOUN
admet-923	437	35	?	?	PUNCT
admet-923	438	1	doi	doi	NOUN
admet-923	438	2	:	:	PUNCT
admet-923	438	3	https:/doi.org/10.5599	https:/doi.org/10.5599	PROPN
admet-923	438	4	/	/	SYM
admet-923	438	5	admet.923	admet.923	PROPN
admet-923	438	6	91	91	NUM
admet-923	438	7	a	a	DET
admet-923	438	8	pn	pn	PROPN
admet-923	438	9	f	f	X
admet-923	438	10	do	do	AUX
admet-923	438	11			X
admet-923	438	12	(	(	PUNCT
admet-923	438	13	4	4	X
admet-923	438	14	)	)	PUNCT
admet-923	438	15	using	use	VERB
admet-923	438	16	eq	eq	NOUN
admet-923	438	17	.	.	PROPN
admet-923	438	18	4	4	NUM
admet-923	438	19	for	for	ADP
admet-923	438	20	fa	fa	PROPN
admet-923	438	21	,	,	PUNCT
admet-923	438	22	the	the	DET
admet-923	438	23	auc	auc	NOUN
admet-923	438	24	value	value	NOUN
admet-923	438	25	after	after	SCONJ
admet-923	438	26	oral	oral	ADJ
admet-923	438	27	administration	administration	NOUN
admet-923	438	28	can	can	AUX
admet-923	438	29	be	be	AUX
admet-923	438	30	expressed	express	VERB
admet-923	438	31	as	as	ADP
admet-923	438	32	:	:	PUNCT
admet-923	438	33	perm	perm	NOUN
admet-923	438	34	si	si	PROPN
admet-923	438	35	g	g	PROPN
admet-923	438	36	h	h	NOUN
admet-923	438	37	perm	perm	NOUN
admet-923	438	38	si	si	INTJ
admet-923	438	39	si	si	PROPN
admet-923	439	1	a	a	DET
admet-923	439	2	g	g	NOUN
admet-923	439	3	h	h	NOUN
admet-923	439	4	g	g	NOUN
admet-923	439	5	h	h	NOUN
admet-923	440	1	g	g	PROPN
admet-923	440	2	h	h	NOUN
admet-923	441	1	si	si	AUX
admet-923	441	2	dose	dose	PROPN
admet-923	441	3	k	k	PROPN
admet-923	441	4	t	t	PROPN
admet-923	441	5	f	f	PROPN
admet-923	441	6	f	f	PROPN
admet-923	441	7	k	k	PROPN
admet-923	441	8	sv	sv	PROPN
admet-923	441	9	tdose	tdose	PROPN
admet-923	441	10	dose	dose	PROPN
admet-923	441	11	dose	dose	PROPN
admet-923	441	12	pn	pn	PROPN
admet-923	441	13	dose	dose	VERB
admet-923	441	14	auc	auc	NOUN
admet-923	442	1	f	f	PROPN
admet-923	443	1	f	f	X
admet-923	443	2	f	f	X
admet-923	444	1	f	f	PROPN
admet-923	444	2	f	f	PROPN
admet-923	444	3	f	f	PROPN
admet-923	444	4	f	f	PROPN
admet-923	444	5	f	f	PROPN
admet-923	444	6	cl	cl	NOUN
admet-923	444	7	cl	cl	NOUN
admet-923	444	8	cl	cl	NOUN
admet-923	444	9	do	do	VERB
admet-923	444	10	cl	cl	NOUN
admet-923	444	11	cl	cl	NOUN
admet-923	444	12	sv	sv	INTJ
admet-923	445	1			NOUN
admet-923	446	1			NUM
admet-923	447	1			ADJ
admet-923	448	1			ADJ
admet-923	448	2			NOUN
admet-923	448	3	(	(	PUNCT
admet-923	448	4	5	5	NUM
admet-923	448	5	)	)	PUNCT
admet-923	448	6	finally	finally	ADV
admet-923	448	7	,	,	PUNCT
admet-923	448	8	g	g	PROPN
admet-923	448	9	h	h	NOUN
admet-923	448	10	eff	eff	PROPN
admet-923	448	11	si	si	PROPN
admet-923	448	12	si	si	PROPN
admet-923	448	13	si	si	PROPN
admet-923	448	14	2f	2f	PROPN
admet-923	449	1	f	f	PROPN
admet-923	449	2	df	df	PROPN
admet-923	449	3	p	p	PROPN
admet-923	449	4	sv	sv	PROPN
admet-923	449	5	t	t	PROPN
admet-923	449	6	auc	auc	NOUN
admet-923	449	7	auc	auc	NOUN
admet-923	449	8	clr	clr	VERB
admet-923	449	9			PROPN
admet-923	449	10			PROPN
admet-923	450	1			PRON
admet-923	451	1			NOUN
admet-923	452	1	(	(	PUNCT
admet-923	452	2	6	6	NUM
admet-923	452	3	)	)	PUNCT
admet-923	452	4	in	in	ADP
admet-923	452	5	the	the	DET
admet-923	452	6	absence	absence	NOUN
admet-923	452	7	of	of	ADP
admet-923	452	8	a	a	DET
admet-923	452	9	unique	unique	ADJ
admet-923	452	10	correspondence	correspondence	NOUN
admet-923	452	11	between	between	ADP
admet-923	452	12	a	a	DET
admet-923	452	13	parameter	parameter	NOUN
admet-923	452	14	and	and	CCONJ
admet-923	452	15	a	a	DET
admet-923	452	16	cp	cp	NOUN
admet-923	452	17	time	time	NOUN
admet-923	452	18	profile	profile	NOUN
admet-923	452	19	,	,	PUNCT
admet-923	452	20	it	it	PRON
admet-923	452	21	is	be	AUX
admet-923	452	22	impossible	impossible	ADJ
admet-923	452	23	to	to	PART
admet-923	452	24	directly	directly	ADV
admet-923	452	25	quantify	quantify	VERB
admet-923	452	26	the	the	DET
admet-923	452	27	physiological	physiological	ADJ
admet-923	452	28	process	process	NOUN
admet-923	452	29	that	that	PRON
admet-923	452	30	involves	involve	VERB
admet-923	452	31	the	the	DET
admet-923	452	32	parameter	parameter	NOUN
admet-923	452	33	.	.	PUNCT
admet-923	453	1	when	when	SCONJ
admet-923	453	2	the	the	DET
admet-923	453	3	parameters	parameter	NOUN
admet-923	453	4	are	be	AUX
admet-923	453	5	in	in	ADP
admet-923	453	6	a	a	DET
admet-923	453	7	multiplication	multiplication	NOUN
admet-923	453	8	relationship	relationship	NOUN
admet-923	453	9	,	,	PUNCT
admet-923	453	10	they	they	PRON
admet-923	453	11	are	be	AUX
admet-923	453	12	structurally	structurally	ADV
admet-923	453	13	non	non	ADJ
admet-923	453	14	-	-	ADJ
admet-923	453	15	identifiable	identifiable	ADJ
admet-923	453	16	from	from	ADP
admet-923	453	17	clinically	clinically	ADV
admet-923	453	18	observed	observe	VERB
admet-923	453	19	data	datum	NOUN
admet-923	453	20	(	(	PUNCT
admet-923	453	21	cf	cf	NOUN
admet-923	453	22	.	.	PUNCT
admet-923	454	1	y	y	PROPN
admet-923	454	2	=	=	PUNCT
admet-923	454	3	abx	abx	PROPN
admet-923	454	4	)	)	PUNCT
admet-923	454	5	.	.	PUNCT
admet-923	455	1	as	as	SCONJ
admet-923	455	2	clearly	clearly	ADV
admet-923	455	3	represented	represent	VERB
admet-923	455	4	in	in	ADP
admet-923	455	5	eq	eq	ADJ
admet-923	455	6	.	.	PROPN
admet-923	455	7	6	6	NUM
admet-923	455	8	,	,	PUNCT
admet-923	455	9	the	the	DET
admet-923	455	10	individual	individual	ADJ
admet-923	455	11	parameters	parameter	NOUN
admet-923	455	12	related	relate	VERB
admet-923	455	13	to	to	ADP
admet-923	455	14	oral	oral	ADJ
admet-923	455	15	drug	drug	NOUN
admet-923	455	16	absorption	absorption	NOUN
admet-923	455	17	can	can	AUX
admet-923	455	18	not	not	PART
admet-923	455	19	be	be	AUX
admet-923	455	20	calculated	calculate	VERB
admet-923	455	21	solely	solely	ADV
admet-923	455	22	using	use	VERB
admet-923	455	23	auc	auc	NOUN
admet-923	455	24	after	after	ADP
admet-923	455	25	oral	oral	ADJ
admet-923	455	26	administration	administration	NOUN
admet-923	455	27	[	[	X
admet-923	455	28	19–22,33	19–22,33	NUM
admet-923	455	29	]	]	PUNCT
admet-923	455	30	.	.	PUNCT
admet-923	456	1	therefore	therefore	ADV
admet-923	456	2	,	,	PUNCT
admet-923	456	3	an	an	DET
admet-923	456	4	oa	oa	PROPN
admet-923	456	5	pbpk	pbpk	PROPN
admet-923	456	6	model	model	NOUN
admet-923	456	7	is	be	AUX
admet-923	456	8	essentially	essentially	ADV
admet-923	456	9	overparameterized	overparameterize	VERB
admet-923	456	10	.	.	PUNCT
admet-923	457	1	to	to	PART
admet-923	457	2	back	back	VERB
admet-923	457	3	-	-	PUNCT
admet-923	457	4	calculate	calculate	NOUN
admet-923	457	5	peff	peff	NOUN
admet-923	457	6	from	from	ADP
admet-923	457	7	fa	fa	PROPN
admet-923	457	8	,	,	PUNCT
admet-923	457	9	the	the	DET
admet-923	457	10	other	other	ADJ
admet-923	457	11	eight	eight	NUM
admet-923	457	12	parameters	parameter	NOUN
admet-923	457	13	(	(	PUNCT
admet-923	457	14	fg	fg	PROPN
admet-923	457	15	,	,	PUNCT
admet-923	457	16	fh	fh	PROPN
admet-923	457	17	,	,	PUNCT
admet-923	457	18	s	s	PROPN
admet-923	457	19	,	,	PUNCT
admet-923	457	20	vsi	vsi	PROPN
admet-923	457	21	,	,	PUNCT
admet-923	457	22	tsi	tsi	PROPN
admet-923	457	23	,	,	PUNCT
admet-923	457	24	rsi	rsi	NOUN
admet-923	457	25	,	,	PUNCT
admet-923	457	26	df	df	NOUN
admet-923	457	27	,	,	PUNCT
admet-923	457	28	and	and	CCONJ
admet-923	457	29	cl	cl	NOUN
admet-923	457	30	)	)	PUNCT
admet-923	457	31	must	must	AUX
admet-923	457	32	be	be	AUX
admet-923	457	33	fixed	fix	VERB
admet-923	457	34	separately	separately	ADV
admet-923	457	35	.	.	PUNCT
admet-923	458	1	parameter	parameter	NOUN
admet-923	458	2	sensitivity	sensitivity	NOUN
admet-923	458	3	analysis	analysis	NOUN
admet-923	458	4	can	can	AUX
admet-923	458	5	be	be	AUX
admet-923	458	6	used	use	VERB
admet-923	458	7	as	as	ADP
admet-923	458	8	a	a	DET
admet-923	458	9	support	support	NOUN
admet-923	458	10	to	to	PART
admet-923	458	11	diagnose	diagnose	VERB
admet-923	458	12	the	the	DET
admet-923	458	13	identifiability	identifiability	NOUN
admet-923	458	14	of	of	ADP
admet-923	458	15	parameters	parameter	NOUN
admet-923	458	16	.	.	PUNCT
admet-923	459	1	however	however	ADV
admet-923	459	2	,	,	PUNCT
admet-923	459	3	auc	auc	NOUN
admet-923	459	4	is	be	AUX
admet-923	459	5	sensitive	sensitive	ADJ
admet-923	459	6	to	to	ADP
admet-923	459	7	all	all	DET
admet-923	459	8	the	the	DET
admet-923	459	9	parameters	parameter	NOUN
admet-923	459	10	on	on	ADP
admet-923	459	11	the	the	DET
admet-923	459	12	right	right	ADJ
admet-923	459	13	-	-	PUNCT
admet-923	459	14	hand	hand	NOUN
admet-923	459	15	side	side	NOUN
admet-923	459	16	of	of	ADP
admet-923	459	17	eq	eq	PROPN
admet-923	459	18	.	.	PROPN
admet-923	459	19	6	6	NUM
admet-923	459	20	.	.	X
admet-923	459	21	being	be	AUX
admet-923	459	22	a	a	DET
admet-923	459	23	sensitive	sensitive	ADJ
admet-923	459	24	parameter	parameter	NOUN
admet-923	459	25	is	be	AUX
admet-923	459	26	a	a	DET
admet-923	459	27	necessary	necessary	ADJ
admet-923	459	28	but	but	CCONJ
admet-923	459	29	not	not	PART
admet-923	459	30	sufficient	sufficient	ADJ
admet-923	459	31	condition	condition	NOUN
admet-923	459	32	to	to	PART
admet-923	459	33	be	be	AUX
admet-923	459	34	identifiable	identifiable	ADJ
admet-923	459	35	[	[	X
admet-923	459	36	19–22	19–22	NUM
admet-923	459	37	]	]	X
admet-923	459	38	.	.	PUNCT
admet-923	460	1	a	a	DET
admet-923	460	2	similar	similar	ADJ
admet-923	460	3	analysis	analysis	NOUN
admet-923	460	4	of	of	ADP
admet-923	460	5	parameter	parameter	NOUN
admet-923	460	6	identifiability	identifiability	NOUN
admet-923	460	7	can	can	AUX
admet-923	460	8	be	be	AUX
admet-923	460	9	performed	perform	VERB
admet-923	460	10	for	for	ADP
admet-923	460	11	cmax	cmax	NOUN
admet-923	460	12	and	and	CCONJ
admet-923	460	13	tmax	tmax	ADV
admet-923	460	14	:	:	PUNCT
admet-923	461	1	el	el	PROPN
admet-923	461	2	el	el	PROPN
admet-923	461	3	aa	aa	PROPN
admet-923	461	4	max	max	PROPN
admet-923	461	5	d	d	PROPN
admet-923	461	6	el	el	PROPN
admet-923	461	7	k	k	PROPN
admet-923	461	8	k	k	PROPN
admet-923	461	9	kkfdose	kkfdose	PROPN
admet-923	461	10	c	c	PROPN
admet-923	461	11	v	v	ADP
admet-923	461	12	k	k	PROPN
admet-923	461	13			PROPN
admet-923	461	14			NOUN
admet-923	462	1			PROPN
admet-923	462	2			PROPN
admet-923	462	3			PROPN
admet-923	463	1			PROPN
admet-923	463	2			NOUN
admet-923	463	3	a	a	DET
admet-923	463	4	max	max	NOUN
admet-923	463	5	a	a	DET
admet-923	463	6	el	el	PROPN
admet-923	463	7	el	el	PROPN
admet-923	463	8	1	1	NUM
admet-923	463	9	ln	ln	NOUN
admet-923	463	10	k	k	PROPN
admet-923	463	11	t	t	PROPN
admet-923	464	1	k	k	PROPN
admet-923	464	2	k	k	PROPN
admet-923	464	3	k	k	PROPN
admet-923	465	1			NOUN
admet-923	465	2			PROPN
admet-923	465	3			PROPN
admet-923	465	4			PROPN
admet-923	466	1			PROPN
admet-923	466	2			PROPN
admet-923	466	3			PROPN
admet-923	466	4			NOUN
admet-923	466	5	where	where	SCONJ
admet-923	466	6	ka	ka	PROPN
admet-923	466	7	is	be	AUX
admet-923	466	8	the	the	DET
admet-923	466	9	absorption	absorption	NOUN
admet-923	466	10	rate	rate	NOUN
admet-923	466	11	constant	constant	ADJ
admet-923	466	12	,	,	PUNCT
admet-923	466	13	kel	kel	PROPN
admet-923	466	14	is	be	AUX
admet-923	466	15	the	the	DET
admet-923	466	16	elimination	elimination	NOUN
admet-923	466	17	rate	rate	NOUN
admet-923	466	18	constant	constant	ADJ
admet-923	466	19	,	,	PUNCT
admet-923	466	20	and	and	CCONJ
admet-923	466	21	vd	vd	NOUN
admet-923	466	22	is	be	AUX
admet-923	466	23	the	the	DET
admet-923	466	24	volume	volume	NOUN
admet-923	466	25	of	of	ADP
admet-923	466	26	distribution	distribution	NOUN
admet-923	466	27	.	.	PUNCT
admet-923	467	1	ka	ka	PROPN
admet-923	467	2	can	can	AUX
admet-923	467	3	be	be	AUX
admet-923	467	4	approximated	approximate	VERB
admet-923	467	5	as	as	ADP
admet-923	467	6	1	1	NUM
admet-923	467	7	/	/	SYM
admet-923	467	8	ka	ka	NOUN
admet-923	467	9	=	=	SYM
admet-923	467	10	1	1	NUM
admet-923	467	11	/	/	SYM
admet-923	467	12	kdiss	kdiss	PROPN
admet-923	467	13	+	+	CCONJ
admet-923	467	14	do	do	AUX
admet-923	467	15	/	/	SYM
admet-923	467	16	kperm	kperm	NOUN
admet-923	467	17	(	(	PUNCT
admet-923	467	18	section	section	NOUN
admet-923	467	19	3.14	3.14	NUM
admet-923	467	20	)	)	PUNCT
admet-923	467	21	.	.	PUNCT
admet-923	468	1	3.6	3.6	NUM
admet-923	468	2	.	.	PUNCT
admet-923	469	1	what	what	PRON
admet-923	469	2	kind	kind	NOUN
admet-923	469	3	of	of	ADP
admet-923	469	4	parameters	parameter	NOUN
admet-923	469	5	can	can	AUX
admet-923	469	6	be	be	AUX
admet-923	469	7	candidates	candidate	NOUN
admet-923	469	8	for	for	ADP
admet-923	469	9	back	back	NOUN
admet-923	469	10	-	-	PUNCT
admet-923	469	11	calculation	calculation	NOUN
admet-923	469	12	?	?	PUNCT
admet-923	470	1	only	only	ADV
admet-923	470	2	an	an	DET
admet-923	470	3	intermediate	intermediate	ADJ
admet-923	470	4	parameter	parameter	NOUN
admet-923	470	5	(	(	PUNCT
admet-923	470	6	e.g.	e.g.	ADV
admet-923	470	7	,	,	PUNCT
admet-923	470	8	peff	peff	NOUN
admet-923	470	9	)	)	PUNCT
admet-923	470	10	or	or	CCONJ
admet-923	470	11	an	an	DET
admet-923	470	12	empirical	empirical	ADJ
admet-923	470	13	scaling	scale	VERB
admet-923	470	14	factor	factor	NOUN
admet-923	470	15	should	should	AUX
admet-923	470	16	be	be	AUX
admet-923	470	17	the	the	DET
admet-923	470	18	candidates	candidate	NOUN
admet-923	470	19	for	for	ADP
admet-923	470	20	the	the	DET
admet-923	470	21	subject	subject	NOUN
admet-923	470	22	of	of	ADP
admet-923	470	23	parameter	parameter	NOUN
admet-923	470	24	back	back	NOUN
admet-923	470	25	-	-	PUNCT
admet-923	470	26	calculation	calculation	NOUN
admet-923	470	27	from	from	ADP
admet-923	470	28	clinical	clinical	ADJ
admet-923	470	29	pk	pk	NOUN
admet-923	470	30	data	datum	NOUN
admet-923	470	31	in	in	ADP
admet-923	470	32	a	a	DET
admet-923	470	33	local	local	ADJ
admet-923	470	34	middle	middle	ADJ
admet-923	470	35	-	-	PUNCT
admet-923	470	36	out	out	ADP
admet-923	470	37	approach	approach	NOUN
admet-923	470	38	(	(	PUNCT
admet-923	470	39	figure	figure	NOUN
admet-923	470	40	2	2	NUM
admet-923	470	41	)	)	PUNCT
admet-923	470	42	.	.	PUNCT
admet-923	471	1	drug	drug	NOUN
admet-923	471	2	-	-	PUNCT
admet-923	471	3	intrinsic	intrinsic	ADJ
admet-923	471	4	parameters	parameter	NOUN
admet-923	471	5	,	,	PUNCT
admet-923	471	6	especially	especially	ADV
admet-923	471	7	physicochemical	physicochemical	ADJ
admet-923	471	8	properties	property	NOUN
admet-923	471	9	,	,	PUNCT
admet-923	471	10	should	should	AUX
admet-923	471	11	not	not	PART
admet-923	471	12	be	be	AUX
admet-923	471	13	the	the	DET
admet-923	471	14	subject	subject	NOUN
admet-923	471	15	of	of	ADP
admet-923	471	16	parameter	parameter	NOUN
admet-923	471	17	back	back	NOUN
admet-923	471	18	-	-	PUNCT
admet-923	471	19	calculation	calculation	NOUN
admet-923	471	20	from	from	ADP
admet-923	471	21	clinical	clinical	ADJ
admet-923	471	22	pk	pk	NOUN
admet-923	471	23	data	datum	NOUN
admet-923	471	24	.	.	PUNCT
admet-923	472	1	they	they	PRON
admet-923	472	2	should	should	AUX
admet-923	472	3	be	be	AUX
admet-923	472	4	determined	determine	VERB
admet-923	472	5	by	by	ADP
admet-923	472	6	in	in	ADP
admet-923	472	7	vitro	vitro	X
admet-923	472	8	measurements	measurement	NOUN
admet-923	472	9	.	.	PUNCT
admet-923	473	1	physiological	physiological	ADJ
admet-923	473	2	parameters	parameter	NOUN
admet-923	473	3	such	such	ADJ
admet-923	473	4	as	as	ADP
admet-923	473	5	the	the	DET
admet-923	473	6	small	small	ADJ
admet-923	473	7	intestinal	intestinal	ADJ
admet-923	473	8	fluid	fluid	NOUN
admet-923	473	9	volume	volume	NOUN
admet-923	473	10	(	(	PUNCT
admet-923	473	11	vsi	vsi	PROPN
admet-923	473	12	)	)	PUNCT
admet-923	473	13	should	should	AUX
admet-923	473	14	not	not	PART
admet-923	473	15	be	be	AUX
admet-923	473	16	the	the	DET
admet-923	473	17	subject	subject	NOUN
admet-923	473	18	of	of	ADP
admet-923	473	19	drugby	drugby	NOUN
admet-923	473	20	-	-	PUNCT
admet-923	473	21	drug	drug	NOUN
admet-923	473	22	back	back	NOUN
admet-923	473	23	-	-	PUNCT
admet-923	473	24	calculation	calculation	NOUN
admet-923	473	25	as	as	ADV
admet-923	473	26	well	well	ADV
admet-923	473	27	,	,	PUNCT
admet-923	473	28	because	because	SCONJ
admet-923	473	29	they	they	PRON
admet-923	473	30	do	do	AUX
admet-923	473	31	not	not	PART
admet-923	473	32	change	change	VERB
admet-923	473	33	drug	drug	NOUN
admet-923	473	34	-	-	PUNCT
admet-923	473	35	by	by	ADP
admet-923	473	36	-	-	PUNCT
admet-923	473	37	drug	drug	NOUN
admet-923	473	38	(	(	PUNCT
admet-923	473	39	except	except	SCONJ
admet-923	473	40	for	for	ADP
admet-923	473	41	drugs	drug	NOUN
admet-923	473	42	with	with	ADP
admet-923	473	43	gastrointestinal	gastrointestinal	ADJ
admet-923	473	44	effects	effect	NOUN
admet-923	473	45	)	)	PUNCT
admet-923	473	46	(	(	PUNCT
admet-923	473	47	a	a	DET
admet-923	473	48	global	global	ADJ
admet-923	473	49	middle	middle	ADJ
admet-923	473	50	-	-	PUNCT
admet-923	473	51	out	out	ADP
admet-923	473	52	approach	approach	NOUN
admet-923	473	53	has	have	AUX
admet-923	473	54	been	be	AUX
admet-923	473	55	used	use	VERB
admet-923	473	56	to	to	PART
admet-923	473	57	estimate	estimate	VERB
admet-923	473	58	some	some	DET
admet-923	473	59	physiological	physiological	ADJ
admet-923	473	60	parameters	parameter	NOUN
admet-923	473	61	when	when	SCONJ
admet-923	473	62	direct	direct	ADJ
admet-923	473	63	measurements	measurement	NOUN
admet-923	473	64	are	be	AUX
admet-923	473	65	not	not	PART
admet-923	473	66	possible	possible	ADJ
admet-923	473	67	(	(	PUNCT
admet-923	473	68	section	section	NOUN
admet-923	473	69	3	3	NUM
admet-923	473	70	-	-	SYM
admet-923	473	71	15	15	NUM
admet-923	473	72	)	)	PUNCT
admet-923	473	73	)	)	PUNCT
admet-923	473	74	.	.	PUNCT
admet-923	474	1	post	post	ADJ
admet-923	474	2	-	-	ADJ
admet-923	474	3	absorptive	absorptive	ADJ
admet-923	474	4	(	(	PUNCT
admet-923	474	5	systemic	systemic	ADJ
admet-923	474	6	)	)	PUNCT
admet-923	474	7	pk	pk	NOUN
admet-923	474	8	parameters	parameter	NOUN
admet-923	474	9	such	such	ADJ
admet-923	474	10	as	as	ADP
admet-923	474	11	cl	cl	NOUN
admet-923	474	12	and	and	CCONJ
admet-923	474	13	vd	vd	NOUN
admet-923	474	14	should	should	AUX
admet-923	474	15	be	be	AUX
admet-923	474	16	determined	determine	VERB
admet-923	474	17	from	from	ADP
admet-923	474	18	i.v	i.v	PROPN
admet-923	474	19	.	.	PUNCT
admet-923	475	1	cp	cp	PROPN
admet-923	475	2	time	time	PROPN
admet-923	475	3	data	datum	NOUN
admet-923	475	4	[	[	X
admet-923	475	5	33	33	NUM
admet-923	475	6	]	]	PUNCT
admet-923	475	7	(	(	PUNCT
admet-923	475	8	unless	unless	SCONJ
admet-923	475	9	f	f	PROPN
admet-923	475	10	=	=	NOUN
admet-923	475	11	1	1	NUM
admet-923	475	12	can	can	AUX
admet-923	475	13	be	be	AUX
admet-923	475	14	surely	surely	ADV
admet-923	475	15	estimated	estimate	VERB
admet-923	475	16	from	from	ADP
admet-923	475	17	in	in	ADP
admet-923	475	18	vitro	vitro	X
admet-923	475	19	data	datum	NOUN
admet-923	475	20	,	,	PUNCT
admet-923	475	21	such	such	ADJ
admet-923	475	22	as	as	ADP
admet-923	475	23	the	the	DET
admet-923	475	24	case	case	NOUN
admet-923	475	25	of	of	ADP
admet-923	475	26	bcs	bcs	NOUN
admet-923	475	27	class	class	NOUN
admet-923	475	28	i	i	PRON
admet-923	475	29	drug	drug	VERB
admet-923	475	30	with	with	ADP
admet-923	475	31	low	low	ADJ
admet-923	475	32	hepatic	hepatic	ADJ
admet-923	475	33	clearance	clearance	NOUN
admet-923	475	34	)	)	PUNCT
admet-923	475	35	.	.	PUNCT
admet-923	476	1	the	the	DET
admet-923	476	2	same	same	ADJ
admet-923	476	3	cl	cl	NOUN
admet-923	476	4	and	and	CCONJ
admet-923	476	5	vd	vd	NOUN
admet-923	476	6	values	value	NOUN
admet-923	476	7	should	should	AUX
admet-923	476	8	be	be	AUX
admet-923	476	9	used	use	VERB
admet-923	476	10	regardless	regardless	ADV
admet-923	476	11	of	of	ADP
admet-923	476	12	formulations	formulation	NOUN
admet-923	476	13	or	or	CCONJ
admet-923	476	14	https://doi.org/10.5599/admet.923	https://doi.org/10.5599/admet.923	NOUN
admet-923	476	15	kiyohiko	kiyohiko	NOUN
admet-923	476	16	sugano	sugano	PROPN
admet-923	476	17	admet	admet	PROPN
admet-923	476	18	&	&	CCONJ
admet-923	476	19	dmpk	dmpk	PROPN
admet-923	476	20	9(2	9(2	NUM
admet-923	476	21	)	)	PUNCT
admet-923	476	22	(	(	PUNCT
admet-923	476	23	2021	2021	NUM
admet-923	476	24	)	)	PUNCT
admet-923	476	25	75	75	NUM
admet-923	476	26	-	-	SYM
admet-923	476	27	109	109	NUM
admet-923	476	28	92	92	NUM
admet-923	476	29	administration	administration	NOUN
admet-923	476	30	routes	route	NOUN
admet-923	476	31	.	.	PUNCT
admet-923	477	1	oral	oral	ADJ
admet-923	477	2	formulation	formulation	NOUN
admet-923	477	3	usually	usually	ADV
admet-923	477	4	does	do	AUX
admet-923	477	5	not	not	PART
admet-923	477	6	affect	affect	VERB
admet-923	477	7	systemic	systemic	ADJ
admet-923	477	8	cl	cl	NOUN
admet-923	477	9	and	and	CCONJ
admet-923	477	10	vd	vd	NOUN
admet-923	477	11	(	(	PUNCT
admet-923	477	12	however	however	ADV
admet-923	477	13	,	,	PUNCT
admet-923	477	14	it	it	PRON
admet-923	477	15	affects	affect	VERB
admet-923	477	16	cl	cl	NOUN
admet-923	477	17	/	/	SYM
admet-923	477	18	f	f	NOUN
admet-923	477	19	and	and	CCONJ
admet-923	477	20	vd	vd	NOUN
admet-923	477	21	/f	/f	PROPN
admet-923	477	22	)	)	PUNCT
admet-923	477	23	.	.	PUNCT
admet-923	478	1	3.7	3.7	NUM
admet-923	478	2	.	.	PUNCT
admet-923	479	1	which	which	DET
admet-923	479	2	candidate	candidate	NOUN
admet-923	479	3	parameter	parameter	NOUN
admet-923	479	4	should	should	AUX
admet-923	479	5	be	be	AUX
admet-923	479	6	selected	select	VERB
admet-923	479	7	for	for	ADP
admet-923	479	8	back	back	NOUN
admet-923	479	9	-	-	PUNCT
admet-923	479	10	calculation	calculation	NOUN
admet-923	479	11	?	?	PUNCT
admet-923	480	1	when	when	SCONJ
admet-923	480	2	multiple	multiple	ADJ
admet-923	480	3	candidate	candidate	NOUN
admet-923	480	4	parameters	parameter	NOUN
admet-923	480	5	can	can	AUX
admet-923	480	6	equally	equally	ADV
admet-923	480	7	explain	explain	VERB
admet-923	480	8	the	the	DET
admet-923	480	9	discrepancy	discrepancy	NOUN
admet-923	480	10	between	between	ADP
admet-923	480	11	prediction	prediction	NOUN
admet-923	480	12	and	and	CCONJ
admet-923	480	13	observation	observation	NOUN
admet-923	480	14	,	,	PUNCT
admet-923	480	15	we	we	PRON
admet-923	480	16	can	can	AUX
admet-923	480	17	not	not	PART
admet-923	480	18	determine	determine	VERB
admet-923	480	19	which	which	DET
admet-923	480	20	one	one	NOUN
admet-923	480	21	to	to	PART
admet-923	480	22	be	be	AUX
admet-923	480	23	selected	select	VERB
admet-923	480	24	for	for	ADP
admet-923	480	25	back	back	NOUN
admet-923	480	26	-	-	PUNCT
admet-923	480	27	calculation	calculation	NOUN
admet-923	480	28	solely	solely	ADV
admet-923	480	29	based	base	VERB
admet-923	480	30	on	on	ADP
admet-923	480	31	the	the	DET
admet-923	480	32	clinical	clinical	ADJ
admet-923	480	33	data	datum	NOUN
admet-923	480	34	.	.	PUNCT
admet-923	481	1	this	this	DET
admet-923	481	2	situation	situation	NOUN
admet-923	481	3	is	be	AUX
admet-923	481	4	like	like	ADP
admet-923	481	5	a	a	DET
admet-923	481	6	checksum	checksum	ADJ
admet-923	481	7	process	process	NOUN
admet-923	481	8	.	.	PUNCT
admet-923	482	1	we	we	PRON
admet-923	482	2	can	can	AUX
admet-923	482	3	validate	validate	VERB
admet-923	482	4	a	a	DET
admet-923	482	5	series	series	NOUN
admet-923	482	6	of	of	ADP
admet-923	482	7	numbers	number	NOUN
admet-923	482	8	by	by	ADP
admet-923	482	9	checking	check	VERB
admet-923	482	10	the	the	DET
admet-923	482	11	sum	sum	NOUN
admet-923	482	12	of	of	ADP
admet-923	482	13	numbers	number	NOUN
admet-923	482	14	,	,	PUNCT
admet-923	482	15	but	but	CCONJ
admet-923	482	16	we	we	PRON
admet-923	482	17	can	can	AUX
admet-923	482	18	not	not	PART
admet-923	482	19	tell	tell	VERB
admet-923	482	20	which	which	DET
admet-923	482	21	number	number	NOUN
admet-923	482	22	has	have	VERB
admet-923	482	23	the	the	DET
admet-923	482	24	error	error	NOUN
admet-923	482	25	.	.	PUNCT
admet-923	483	1	the	the	DET
admet-923	483	2	selection	selection	NOUN
admet-923	483	3	of	of	ADP
admet-923	483	4	a	a	DET
admet-923	483	5	parameter	parameter	NOUN
admet-923	483	6	depends	depend	VERB
admet-923	483	7	on	on	ADP
admet-923	483	8	the	the	DET
admet-923	483	9	clinical	clinical	ADJ
admet-923	483	10	study	study	NOUN
admet-923	483	11	design	design	NOUN
admet-923	483	12	and	and	CCONJ
admet-923	483	13	the	the	DET
admet-923	483	14	reliability	reliability	NOUN
admet-923	483	15	of	of	ADP
admet-923	483	16	the	the	DET
admet-923	483	17	estimation	estimation	NOUN
admet-923	483	18	from	from	ADP
admet-923	483	19	in	in	ADP
admet-923	483	20	vitro	vitro	X
admet-923	483	21	data	datum	NOUN
admet-923	483	22	(	(	PUNCT
admet-923	483	23	section	section	NOUN
admet-923	483	24	3	3	NUM
admet-923	483	25	-	-	SYM
admet-923	483	26	8	8	NUM
admet-923	483	27	,	,	PUNCT
admet-923	483	28	(	(	PUNCT
admet-923	483	29	iv	iv	NOUN
admet-923	483	30	)	)	PUNCT
admet-923	483	31	)	)	PUNCT
admet-923	483	32	.	.	PUNCT
admet-923	484	1	identifiability	identifiability	NOUN
admet-923	484	2	issues	issue	NOUN
admet-923	484	3	can	can	AUX
admet-923	484	4	be	be	AUX
admet-923	484	5	even	even	ADV
admet-923	484	6	more	more	ADV
admet-923	484	7	severe	severe	ADJ
admet-923	484	8	when	when	SCONJ
admet-923	484	9	there	there	PRON
admet-923	484	10	are	be	VERB
admet-923	484	11	regional	regional	ADJ
admet-923	484	12	differences	difference	NOUN
admet-923	484	13	in	in	ADP
admet-923	484	14	the	the	DET
admet-923	484	15	gastrointestinal	gastrointestinal	ADJ
admet-923	484	16	parameters	parameter	NOUN
admet-923	484	17	in	in	ADP
admet-923	484	18	eq	eq	ADP
admet-923	484	19	6	6	NUM
admet-923	484	20	.	.	PUNCT
admet-923	484	21	3.8	3.8	NUM
admet-923	484	22	.	.	PUNCT
admet-923	485	1	how	how	SCONJ
admet-923	485	2	to	to	PART
admet-923	485	3	fix	fix	VERB
admet-923	485	4	the	the	DET
admet-923	485	5	other	other	ADJ
admet-923	485	6	parameters	parameter	NOUN
admet-923	485	7	there	there	PRON
admet-923	485	8	are	be	VERB
admet-923	485	9	several	several	ADJ
admet-923	485	10	methods	method	NOUN
admet-923	485	11	to	to	PART
admet-923	485	12	fix	fix	VERB
admet-923	485	13	the	the	DET
admet-923	485	14	other	other	ADJ
admet-923	485	15	parameter	parameter	NOUN
admet-923	485	16	values	value	NOUN
admet-923	485	17	.	.	PUNCT
admet-923	486	1	(	(	PUNCT
admet-923	486	2	i	i	NOUN
admet-923	486	3	)	)	PUNCT
admet-923	486	4	clinical	clinical	ADJ
admet-923	486	5	study	study	NOUN
admet-923	486	6	using	use	VERB
admet-923	486	7	different	different	ADJ
admet-923	486	8	administration	administration	NOUN
admet-923	486	9	routes	route	NOUN
admet-923	486	10	and	and	CCONJ
admet-923	486	11	formulations	formulation	NOUN
admet-923	486	12	to	to	PART
admet-923	486	13	reliably	reliably	ADV
admet-923	486	14	estimate	estimate	VERB
admet-923	486	15	a	a	DET
admet-923	486	16	parameter	parameter	NOUN
admet-923	486	17	from	from	ADP
admet-923	486	18	clinical	clinical	ADJ
admet-923	486	19	pk	pk	NOUN
admet-923	486	20	data	datum	NOUN
admet-923	486	21	,	,	PUNCT
admet-923	486	22	the	the	DET
admet-923	486	23	interference	interference	NOUN
admet-923	486	24	of	of	ADP
admet-923	486	25	confounding	confound	VERB
admet-923	486	26	factors	factor	NOUN
admet-923	486	27	must	must	AUX
admet-923	486	28	be	be	AUX
admet-923	486	29	reduced	reduce	VERB
admet-923	486	30	as	as	ADV
admet-923	486	31	much	much	ADV
admet-923	486	32	as	as	ADP
admet-923	486	33	possible	possible	ADJ
admet-923	486	34	.	.	PUNCT
admet-923	487	1	a	a	DET
admet-923	487	2	specific	specific	ADJ
admet-923	487	3	clinical	clinical	ADJ
admet-923	487	4	study	study	NOUN
admet-923	487	5	design	design	NOUN
admet-923	487	6	has	have	AUX
admet-923	487	7	been	be	AUX
admet-923	487	8	employed	employ	VERB
admet-923	487	9	to	to	PART
admet-923	487	10	eliminate	eliminate	VERB
admet-923	487	11	the	the	DET
admet-923	487	12	confounding	confound	VERB
admet-923	487	13	factors	factor	NOUN
admet-923	487	14	for	for	ADP
admet-923	487	15	each	each	DET
admet-923	487	16	parameter	parameter	NOUN
admet-923	487	17	(	(	PUNCT
admet-923	487	18	table	table	NOUN
admet-923	487	19	2	2	NUM
admet-923	487	20	)	)	PUNCT
admet-923	487	21	(	(	PUNCT
admet-923	487	22	see	see	VERB
admet-923	487	23	also	also	ADV
admet-923	487	24	(	(	PUNCT
admet-923	487	25	3.13	3.13	NUM
admet-923	487	26	)	)	PUNCT
admet-923	487	27	)	)	PUNCT
admet-923	487	28	.	.	PUNCT
admet-923	488	1	for	for	ADP
admet-923	488	2	example	example	NOUN
admet-923	488	3	,	,	PUNCT
admet-923	488	4	systemic	systemic	ADJ
admet-923	488	5	clearance	clearance	NOUN
admet-923	488	6	(	(	PUNCT
admet-923	488	7	cl	cl	NOUN
admet-923	488	8	)	)	PUNCT
admet-923	488	9	can	can	AUX
admet-923	488	10	be	be	AUX
admet-923	488	11	obtained	obtain	VERB
admet-923	488	12	from	from	ADP
admet-923	488	13	i.v	i.v	PROPN
admet-923	488	14	.	.	PUNCT
admet-923	488	15	data	data	PROPN
admet-923	488	16	.	.	PUNCT
admet-923	489	1	an	an	DET
admet-923	489	2	i.v	i.v	PROPN
admet-923	489	3	.	.	PUNCT
admet-923	489	4	administration	administration	NOUN
admet-923	489	5	eliminates	eliminate	VERB
admet-923	489	6	the	the	DET
admet-923	489	7	oral	oral	ADJ
admet-923	489	8	absorption	absorption	NOUN
admet-923	489	9	process	process	NOUN
admet-923	489	10	(	(	PUNCT
admet-923	489	11	f	f	NOUN
admet-923	489	12	=	=	SYM
admet-923	489	13	1	1	NUM
admet-923	489	14	)	)	PUNCT
admet-923	489	15	,	,	PUNCT
admet-923	489	16	so	so	SCONJ
admet-923	489	17	that	that	PRON
admet-923	489	18	cl	cl	NOUN
admet-923	489	19	become	become	VERB
admet-923	489	20	identifiable	identifiable	ADJ
admet-923	489	21	from	from	ADP
admet-923	489	22	auc	auc	NOUN
admet-923	489	23	(	(	PUNCT
admet-923	489	24	cf	cf	NOUN
admet-923	489	25	.	.	PUNCT
admet-923	490	1	cl	cl	NOUN
admet-923	491	1	=	=	PUNCT
admet-923	491	2	dose	dose	NOUN
admet-923	491	3	/	/	SYM
admet-923	491	4	auc	auc	NOUN
admet-923	491	5	)	)	PUNCT
admet-923	491	6	.	.	PUNCT
admet-923	492	1	vd	vd	NOUN
admet-923	492	2	and	and	CCONJ
admet-923	492	3	fh	fh	PROPN
admet-923	492	4	can	can	AUX
admet-923	492	5	also	also	ADV
admet-923	492	6	be	be	AUX
admet-923	492	7	calculated	calculate	VERB
admet-923	492	8	from	from	ADP
admet-923	492	9	the	the	DET
admet-923	492	10	i.v	i.v	PROPN
admet-923	492	11	.	.	PUNCT
admet-923	492	12	data	datum	NOUN
admet-923	493	1	[	[	X
admet-923	493	2	150	150	NUM
admet-923	493	3	]	]	PUNCT
admet-923	493	4	.	.	PUNCT
admet-923	494	1	an	an	DET
admet-923	494	2	oral	oral	ADJ
admet-923	494	3	solution	solution	NOUN
admet-923	494	4	formulation	formulation	NOUN
admet-923	494	5	can	can	AUX
admet-923	494	6	be	be	AUX
admet-923	494	7	used	use	VERB
admet-923	494	8	to	to	PART
admet-923	494	9	eliminate	eliminate	VERB
admet-923	494	10	dn	dn	NOUN
admet-923	494	11	from	from	ADP
admet-923	494	12	eq	eq	NOUN
admet-923	494	13	.	.	PROPN
admet-923	494	14	2	2	NUM
admet-923	494	15	(	(	PUNCT
admet-923	494	16	1	1	NUM
admet-923	494	17	/	/	SYM
admet-923	494	18	dn	dn	NOUN
admet-923	494	19	becomes	become	VERB
admet-923	494	20	negligible	negligible	ADJ
admet-923	494	21	)	)	PUNCT
admet-923	494	22	,	,	PUNCT
admet-923	494	23	and	and	CCONJ
admet-923	494	24	s	s	PROPN
admet-923	494	25	and	and	CCONJ
admet-923	494	26	vsi	vsi	PROPN
admet-923	494	27	from	from	ADP
admet-923	494	28	eq	eq	PROPN
admet-923	494	29	.	.	PROPN
admet-923	494	30	6	6	NUM
admet-923	494	31	(	(	PUNCT
admet-923	494	32	mathematically	mathematically	ADV
admet-923	494	33	,	,	PUNCT
admet-923	494	34	by	by	ADP
admet-923	494	35	fixing	fix	VERB
admet-923	494	36	do	do	AUX
admet-923	494	37	=	=	SYM
admet-923	494	38	1	1	NUM
admet-923	494	39	)	)	PUNCT
admet-923	494	40	.	.	PUNCT
admet-923	495	1	table	table	NOUN
admet-923	495	2	2	2	NUM
admet-923	495	3	.	.	PUNCT
admet-923	496	1	the	the	DET
admet-923	496	2	parameters	parameter	NOUN
admet-923	496	3	and	and	CCONJ
admet-923	496	4	the	the	DET
admet-923	496	5	clinical	clinical	ADJ
admet-923	496	6	study	study	NOUN
admet-923	496	7	design	design	NOUN
admet-923	496	8	parameter	parameter	NOUN
admet-923	496	9	clinical	clinical	ADJ
admet-923	496	10	study	study	NOUN
admet-923	496	11	design	design	NOUN
admet-923	496	12	reference	reference	NOUN
admet-923	496	13	cl	cl	NOUN
admet-923	496	14	,	,	PUNCT
admet-923	496	15	vd	vd	ADP
admet-923	496	16	i.v	i.v	PROPN
admet-923	496	17	.	.	PUNCT
admet-923	497	1	administration	administration	PROPN
admet-923	497	2	-a	-a	PROPN
admet-923	497	3	peff	peff	PROPN
admet-923	497	4	site	site	NOUN
admet-923	497	5	-	-	PUNCT
admet-923	497	6	specific	specific	ADJ
admet-923	497	7	solution	solution	NOUN
admet-923	497	8	administration	administration	NOUN
admet-923	497	9	and	and	CCONJ
admet-923	497	10	i.v	i.v	PROPN
admet-923	497	11	.	.	PROPN
admet-923	498	1	administration	administration	PROPN
admet-923	499	1	[	[	X
admet-923	499	2	151	151	NUM
admet-923	499	3	]	]	PUNCT
admet-923	499	4	precipitation	precipitation	NOUN
admet-923	499	5	rate	rate	NOUN
admet-923	499	6	site	site	NOUN
admet-923	499	7	-	-	PUNCT
admet-923	499	8	specific	specific	ADJ
admet-923	499	9	solution	solution	NOUN
admet-923	499	10	administration	administration	NOUN
admet-923	499	11	and	and	CCONJ
admet-923	499	12	sampling	sample	VERB
admet-923	499	13	[	[	X
admet-923	499	14	152][153	152][153	NUM
admet-923	499	15	]	]	PUNCT
admet-923	499	16	a	a	DET
admet-923	499	17	see	see	VERB
admet-923	499	18	any	any	DET
admet-923	499	19	pharmacokinetic	pharmacokinetic	ADJ
admet-923	499	20	textbook	textbook	NOUN
admet-923	499	21	it	it	PRON
admet-923	499	22	is	be	AUX
admet-923	499	23	not	not	PART
admet-923	499	24	known	know	VERB
admet-923	499	25	whether	whether	SCONJ
admet-923	499	26	parameter	parameter	NOUN
admet-923	499	27	back	back	NOUN
admet-923	499	28	-	-	PUNCT
admet-923	499	29	calculation	calculation	NOUN
admet-923	499	30	from	from	ADP
admet-923	499	31	the	the	DET
admet-923	499	32	oral	oral	ADJ
admet-923	499	33	cp	cp	PROPN
admet-923	499	34	time	time	NOUN
admet-923	499	35	data	datum	NOUN
admet-923	499	36	after	after	SCONJ
admet-923	499	37	the	the	DET
admet-923	499	38	administration	administration	NOUN
admet-923	499	39	of	of	ADP
admet-923	499	40	solid	solid	ADJ
admet-923	499	41	dosage	dosage	NOUN
admet-923	499	42	forms	form	NOUN
admet-923	499	43	can	can	AUX
admet-923	499	44	be	be	AUX
admet-923	499	45	accurate	accurate	ADJ
admet-923	499	46	.	.	PUNCT
admet-923	500	1	theoretically	theoretically	ADV
admet-923	500	2	,	,	PUNCT
admet-923	500	3	the	the	DET
admet-923	500	4	dissolution	dissolution	NOUN
admet-923	500	5	processes	process	NOUN
admet-923	500	6	can	can	AUX
admet-923	500	7	be	be	AUX
admet-923	500	8	decomposed	decompose	VERB
admet-923	500	9	from	from	ADP
admet-923	500	10	the	the	DET
admet-923	500	11	permeation	permeation	NOUN
admet-923	500	12	process	process	NOUN
admet-923	500	13	by	by	ADP
admet-923	500	14	using	use	VERB
admet-923	500	15	the	the	DET
admet-923	500	16	cp	cp	PROPN
admet-923	500	17	time	time	NOUN
admet-923	500	18	data	datum	NOUN
admet-923	500	19	from	from	ADP
admet-923	500	20	solution	solution	NOUN
admet-923	500	21	formulations	formulation	NOUN
admet-923	500	22	[	[	X
admet-923	500	23	154	154	NUM
admet-923	500	24	]	]	PUNCT
admet-923	500	25	.	.	PUNCT
admet-923	501	1	however	however	ADV
admet-923	501	2	,	,	PUNCT
admet-923	501	3	this	this	DET
admet-923	501	4	deconvolution	deconvolution	NOUN
admet-923	501	5	process	process	NOUN
admet-923	501	6	often	often	ADV
admet-923	501	7	becomes	become	VERB
admet-923	501	8	unstable	unstable	ADJ
admet-923	501	9	due	due	ADP
admet-923	501	10	to	to	ADP
admet-923	501	11	the	the	DET
admet-923	501	12	variation	variation	NOUN
admet-923	501	13	of	of	ADP
admet-923	501	14	the	the	DET
admet-923	501	15	data	datum	NOUN
admet-923	501	16	.	.	PUNCT
admet-923	502	1	in	in	ADP
admet-923	502	2	addition	addition	NOUN
admet-923	502	3	,	,	PUNCT
admet-923	502	4	there	there	PRON
admet-923	502	5	has	have	AUX
admet-923	502	6	been	be	AUX
admet-923	502	7	no	no	DET
admet-923	502	8	systematic	systematic	ADJ
admet-923	502	9	evaluation	evaluation	NOUN
admet-923	502	10	of	of	ADP
admet-923	502	11	peff	peff	PROPN
admet-923	502	12	back	back	NOUN
admet-923	502	13	-	-	PUNCT
admet-923	502	14	calculation	calculation	NOUN
admet-923	502	15	from	from	ADP
admet-923	502	16	the	the	DET
admet-923	502	17	oral	oral	ADJ
admet-923	502	18	cp	cp	PROPN
admet-923	502	19	time	time	NOUN
admet-923	502	20	data	datum	NOUN
admet-923	502	21	after	after	ADP
admet-923	502	22	the	the	DET
admet-923	502	23	administration	administration	NOUN
admet-923	502	24	of	of	ADP
admet-923	502	25	solid	solid	ADJ
admet-923	502	26	dosage	dosage	NOUN
admet-923	502	27	forms	form	NOUN
admet-923	502	28	.	.	PUNCT
admet-923	503	1	unfortunately	unfortunately	ADV
admet-923	503	2	,	,	PUNCT
admet-923	503	3	in	in	ADP
admet-923	503	4	the	the	DET
admet-923	503	5	literature	literature	NOUN
admet-923	503	6	,	,	PUNCT
admet-923	503	7	peff	peff	PROPN
admet-923	503	8	has	have	AUX
admet-923	503	9	been	be	AUX
admet-923	503	10	back	back	ADV
admet-923	503	11	-	-	PUNCT
admet-923	503	12	calculated	calculate	VERB
admet-923	503	13	even	even	ADV
admet-923	503	14	in	in	ADP
admet-923	503	15	the	the	DET
admet-923	503	16	absence	absence	NOUN
admet-923	503	17	of	of	ADP
admet-923	503	18	i.v	i.v	PROPN
admet-923	503	19	.	.	PUNCT
admet-923	503	20	data	datum	NOUN
admet-923	503	21	in	in	ADP
admet-923	503	22	many	many	ADJ
admet-923	503	23	cases	case	NOUN
admet-923	503	24	.	.	PUNCT
admet-923	504	1	the	the	DET
admet-923	504	2	credibility	credibility	NOUN
admet-923	504	3	of	of	ADP
admet-923	504	4	such	such	ADJ
admet-923	504	5	peff	peff	PROPN
admet-923	504	6	back	back	NOUN
admet-923	504	7	-	-	PUNCT
admet-923	504	8	calculation	calculation	NOUN
admet-923	504	9	is	be	AUX
admet-923	504	10	at	at	ADP
admet-923	504	11	least	least	ADJ
admet-923	504	12	questionable	questionable	ADJ
admet-923	504	13	(	(	PUNCT
admet-923	504	14	section	section	NOUN
admet-923	504	15	3.9	3.9	NUM
admet-923	504	16	)	)	PUNCT
admet-923	504	17	.	.	PUNCT
admet-923	505	1	(	(	PUNCT
admet-923	505	2	ii	ii	NOUN
admet-923	505	3	)	)	PUNCT
admet-923	505	4	experimentally	experimentally	ADV
admet-923	505	5	measured	measure	VERB
admet-923	505	6	physiological	physiological	ADJ
admet-923	505	7	parameters	parameter	NOUN
admet-923	505	8	experimentally	experimentally	ADV
admet-923	505	9	measured	measure	VERB
admet-923	505	10	physiological	physiological	ADJ
admet-923	505	11	parameters	parameter	NOUN
admet-923	505	12	can	can	AUX
admet-923	505	13	be	be	AUX
admet-923	505	14	obtained	obtain	VERB
admet-923	505	15	from	from	ADP
admet-923	505	16	the	the	DET
admet-923	505	17	literature	literature	NOUN
admet-923	505	18	(	(	PUNCT
admet-923	505	19	vsi	vsi	PROPN
admet-923	505	20	,	,	PUNCT
admet-923	505	21	tsi	tsi	PROPN
admet-923	505	22	,	,	PUNCT
admet-923	505	23	and	and	CCONJ
admet-923	505	24	rsi	rsi	VERB
admet-923	505	25	in	in	ADP
admet-923	505	26	eq	eq	ADP
admet-923	505	27	.	.	PROPN
admet-923	505	28	6	6	NUM
admet-923	505	29	)	)	PUNCT
admet-923	505	30	.	.	PUNCT
admet-923	506	1	however	however	ADV
admet-923	506	2	,	,	PUNCT
admet-923	506	3	it	it	PRON
admet-923	506	4	should	should	AUX
admet-923	506	5	be	be	AUX
admet-923	506	6	noted	note	VERB
admet-923	506	7	that	that	SCONJ
admet-923	506	8	some	some	PRON
admet-923	506	9	of	of	ADP
admet-923	506	10	the	the	DET
admet-923	506	11	physiological	physiological	ADJ
admet-923	506	12	parameters	parameter	NOUN
admet-923	506	13	reported	report	VERB
admet-923	506	14	in	in	ADP
admet-923	506	15	the	the	DET
admet-923	506	16	literature	literature	NOUN
admet-923	506	17	have	have	VERB
admet-923	506	18	large	large	ADJ
admet-923	506	19	variations	variation	NOUN
admet-923	506	20	between	between	ADP
admet-923	506	21	subjects	subject	NOUN
admet-923	506	22	and	and	CCONJ
admet-923	506	23	between	between	ADP
admet-923	506	24	occasions	occasion	NOUN
admet-923	506	25	.	.	PUNCT
admet-923	507	1	(	(	PUNCT
admet-923	507	2	iii	iii	X
admet-923	507	3	)	)	PUNCT
admet-923	507	4	physiological	physiological	ADJ
admet-923	507	5	parameters	parameter	NOUN
admet-923	507	6	estimated	estimate	VERB
admet-923	507	7	by	by	ADP
admet-923	507	8	a	a	DET
admet-923	507	9	global	global	ADJ
admet-923	507	10	middle	middle	ADJ
admet-923	507	11	-	-	PUNCT
admet-923	507	12	out	out	NOUN
admet-923	507	13	approach	approach	NOUN
admet-923	507	14	the	the	DET
admet-923	507	15	global	global	ADJ
admet-923	507	16	middle	middle	ADJ
admet-923	507	17	-	-	PUNCT
admet-923	507	18	out	out	ADP
admet-923	507	19	approach	approach	NOUN
admet-923	507	20	has	have	AUX
admet-923	507	21	been	be	AUX
admet-923	507	22	used	use	VERB
admet-923	507	23	to	to	PART
admet-923	507	24	back	back	ADJ
admet-923	507	25	-	-	PUNCT
admet-923	507	26	estimate	estimate	VERB
admet-923	507	27	an	an	DET
admet-923	507	28	unknown	unknown	ADJ
admet-923	507	29	physiological	physiological	ADJ
admet-923	507	30	parameter	parameter	NOUN
admet-923	507	31	from	from	ADP
admet-923	507	32	clinical	clinical	ADJ
admet-923	507	33	pk	pk	NOUN
admet-923	507	34	data	datum	NOUN
admet-923	507	35	(	(	PUNCT
admet-923	507	36	df	df	NOUN
admet-923	507	37	in	in	ADP
admet-923	507	38	eq	eq	ADP
admet-923	507	39	.	.	PROPN
admet-923	507	40	6	6	NUM
admet-923	507	41	,	,	PUNCT
admet-923	507	42	section	section	NOUN
admet-923	507	43	3.15	3.15	NUM
admet-923	507	44	)	)	PUNCT
admet-923	507	45	.	.	PUNCT
admet-923	508	1	admet	admet	PROPN
admet-923	508	2	&	&	CCONJ
admet-923	508	3	dmpk	dmpk	PROPN
admet-923	508	4	9(2	9(2	NUM
admet-923	508	5	)	)	PUNCT
admet-923	508	6	(	(	PUNCT
admet-923	508	7	2021	2021	NUM
admet-923	508	8	)	)	PUNCT
admet-923	508	9	75	75	NUM
admet-923	508	10	-	-	SYM
admet-923	508	11	109	109	NUM
admet-923	508	12	lost	lose	VERB
admet-923	508	13	in	in	ADP
admet-923	508	14	modelling	modelling	NOUN
admet-923	508	15	and	and	CCONJ
admet-923	508	16	simulation	simulation	NOUN
admet-923	508	17	?	?	PUNCT
admet-923	509	1	doi	doi	NOUN
admet-923	509	2	:	:	PUNCT
admet-923	509	3	https:/doi.org/10.5599	https:/doi.org/10.5599	PROPN
admet-923	509	4	/	/	SYM
admet-923	509	5	admet.923	admet.923	NUM
admet-923	509	6	93	93	NUM
admet-923	509	7	(	(	PUNCT
admet-923	509	8	iv	iv	X
admet-923	509	9	)	)	PUNCT
admet-923	509	10	preclinical	preclinical	NOUN
admet-923	509	11	in	in	ADP
admet-923	509	12	silico	silico	NOUN
admet-923	509	13	,	,	PUNCT
admet-923	509	14	in	in	ADP
admet-923	509	15	vitro	vitro	NOUN
admet-923	509	16	,	,	PUNCT
admet-923	509	17	and	and	CCONJ
admet-923	509	18	in	in	ADP
admet-923	509	19	vivo	vivo	ADJ
admet-923	509	20	data	datum	NOUN
admet-923	509	21	preclinical	preclinical	ADJ
admet-923	509	22	in	in	ADP
admet-923	509	23	silico	silico	NOUN
admet-923	509	24	,	,	PUNCT
admet-923	509	25	in	in	ADP
admet-923	509	26	vitro	vitro	NOUN
admet-923	509	27	,	,	PUNCT
admet-923	509	28	and	and	CCONJ
admet-923	509	29	in	in	ADP
admet-923	509	30	vivo	vivo	ADJ
admet-923	509	31	data	datum	NOUN
admet-923	509	32	can	can	AUX
admet-923	509	33	be	be	AUX
admet-923	509	34	used	use	VERB
admet-923	509	35	to	to	PART
admet-923	509	36	fix	fix	VERB
admet-923	509	37	a	a	DET
admet-923	509	38	parameter	parameter	NOUN
admet-923	509	39	if	if	SCONJ
admet-923	509	40	their	their	PRON
admet-923	509	41	predictability	predictability	NOUN
admet-923	509	42	is	be	AUX
admet-923	509	43	sufficient	sufficient	ADJ
admet-923	509	44	considering	consider	VERB
admet-923	509	45	the	the	DET
admet-923	509	46	contest	contest	NOUN
admet-923	509	47	of	of	ADP
admet-923	509	48	use	use	NOUN
admet-923	509	49	(	(	PUNCT
admet-923	509	50	cou	cou	NOUN
admet-923	509	51	)	)	PUNCT
admet-923	509	52	(	(	PUNCT
admet-923	509	53	section	section	NOUN
admet-923	509	54	1.2	1.2	NUM
admet-923	509	55	)	)	PUNCT
admet-923	509	56	.	.	PUNCT
admet-923	510	1	the	the	DET
admet-923	510	2	in	in	ADP
admet-923	510	3	vitro	vitro	X
admet-923	510	4	equilibrium	equilibrium	NOUN
admet-923	510	5	solubility	solubility	NOUN
admet-923	510	6	in	in	ADP
admet-923	510	7	biorelevant	biorelevant	ADJ
admet-923	510	8	media	medium	NOUN
admet-923	510	9	such	such	ADJ
admet-923	510	10	as	as	ADP
admet-923	510	11	fassif	fassif	NOUN
admet-923	510	12	and	and	CCONJ
admet-923	510	13	fessif	fessif	NOUN
admet-923	510	14	has	have	AUX
admet-923	510	15	often	often	ADV
admet-923	510	16	been	be	AUX
admet-923	510	17	assumed	assume	VERB
admet-923	510	18	to	to	PART
admet-923	510	19	be	be	AUX
admet-923	510	20	in	in	ADP
admet-923	510	21	vivo	vivo	ADJ
admet-923	510	22	predictive	predictive	NOUN
admet-923	510	23	.	.	PUNCT
admet-923	511	1	however	however	ADV
admet-923	511	2	,	,	PUNCT
admet-923	511	3	it	it	PRON
admet-923	511	4	should	should	AUX
admet-923	511	5	be	be	AUX
admet-923	511	6	noted	note	VERB
admet-923	511	7	that	that	SCONJ
admet-923	511	8	these	these	PRON
admet-923	511	9	are	be	AUX
admet-923	511	10	simplified	simplify	VERB
admet-923	511	11	artificial	artificial	ADJ
admet-923	511	12	fluids	fluid	NOUN
admet-923	511	13	,	,	PUNCT
admet-923	511	14	not	not	PART
admet-923	511	15	actual	actual	ADJ
admet-923	511	16	intestinal	intestinal	ADJ
admet-923	511	17	fluids	fluid	NOUN
admet-923	511	18	.	.	PUNCT
admet-923	512	1	fassif	fassif	NOUN
admet-923	512	2	and	and	CCONJ
admet-923	512	3	fessif	fessif	NOUN
admet-923	512	4	are	be	AUX
admet-923	512	5	very	very	ADV
admet-923	512	6	good	good	ADJ
admet-923	512	7	model	model	NOUN
admet-923	512	8	fluids	fluid	NOUN
admet-923	512	9	,	,	PUNCT
admet-923	512	10	yet	yet	ADV
admet-923	512	11	,	,	PUNCT
admet-923	512	12	the	the	DET
admet-923	512	13	solubility	solubility	NOUN
admet-923	512	14	values	value	NOUN
admet-923	512	15	do	do	AUX
admet-923	512	16	not	not	PART
admet-923	512	17	always	always	ADV
admet-923	512	18	accurately	accurately	ADV
admet-923	512	19	reflect	reflect	VERB
admet-923	512	20	the	the	DET
admet-923	512	21	real	real	ADJ
admet-923	512	22	in	in	ADP
admet-923	512	23	vivo	vivo	ADJ
admet-923	512	24	values	value	NOUN
admet-923	512	25	[	[	X
admet-923	512	26	155	155	NUM
admet-923	512	27	]	]	PUNCT
admet-923	512	28	.	.	PUNCT
admet-923	513	1	in	in	ADP
admet-923	513	2	addition	addition	NOUN
admet-923	513	3	,	,	PUNCT
admet-923	513	4	the	the	DET
admet-923	513	5	solubility	solubility	NOUN
admet-923	513	6	data	datum	NOUN
admet-923	513	7	could	could	AUX
admet-923	513	8	be	be	AUX
admet-923	513	9	inaccurate	inaccurate	ADJ
admet-923	513	10	when	when	SCONJ
admet-923	513	11	inappropriately	inappropriately	ADV
admet-923	513	12	measured	measure	VERB
admet-923	513	13	[	[	X
admet-923	513	14	109	109	NUM
admet-923	513	15	]	]	PUNCT
admet-923	513	16	.	.	PUNCT
admet-923	514	1	current	current	ADJ
admet-923	514	2	in	in	ADP
admet-923	514	3	vitro	vitro	NOUN
admet-923	514	4	-	-	PUNCT
admet-923	514	5	in	in	ADP
admet-923	514	6	vivo	vivo	ADJ
admet-923	514	7	extrapolation	extrapolation	NOUN
admet-923	514	8	(	(	PUNCT
admet-923	514	9	ivive	ivive	ADJ
admet-923	514	10	)	)	PUNCT
admet-923	514	11	and	and	CCONJ
admet-923	514	12	allometric	allometric	ADJ
admet-923	514	13	scaling	scaling	NOUN
admet-923	514	14	for	for	ADP
admet-923	514	15	cl	cl	NOUN
admet-923	514	16	and	and	CCONJ
admet-923	514	17	vd	vd	NOUN
admet-923	514	18	is	be	AUX
admet-923	514	19	not	not	PART
admet-923	514	20	sufficiently	sufficiently	ADV
admet-923	514	21	accurate	accurate	ADJ
admet-923	514	22	for	for	ADP
admet-923	514	23	the	the	DET
admet-923	514	24	cous	cous	NOUN
admet-923	514	25	of	of	ADP
admet-923	514	26	oa	oa	PROPN
admet-923	514	27	pbpk	pbpk	NOUN
admet-923	514	28	modelling	modelling	NOUN
admet-923	514	29	in	in	ADP
admet-923	514	30	the	the	DET
admet-923	514	31	late	late	ADJ
admet-923	514	32	drug	drug	NOUN
admet-923	514	33	development	development	NOUN
admet-923	514	34	stage	stage	NOUN
admet-923	514	35	[	[	X
admet-923	514	36	7	7	NUM
admet-923	514	37	]	]	PUNCT
admet-923	514	38	.	.	PUNCT
admet-923	515	1	in	in	ADP
admet-923	515	2	silico	silico	NOUN
admet-923	515	3	models	model	NOUN
admet-923	515	4	for	for	ADP
admet-923	515	5	the	the	DET
admet-923	515	6	physicochemical	physicochemical	ADJ
admet-923	515	7	properties	property	NOUN
admet-923	515	8	and	and	CCONJ
admet-923	515	9	other	other	ADJ
admet-923	515	10	adme	adme	NOUN
admet-923	515	11	properties	property	NOUN
admet-923	515	12	of	of	ADP
admet-923	515	13	a	a	DET
admet-923	515	14	drug	drug	NOUN
admet-923	515	15	are	be	AUX
admet-923	515	16	not	not	PART
admet-923	515	17	so	so	ADV
admet-923	515	18	accurate	accurate	ADJ
admet-923	515	19	as	as	SCONJ
admet-923	515	20	to	to	PART
admet-923	515	21	be	be	AUX
admet-923	515	22	used	use	VERB
admet-923	515	23	for	for	ADP
admet-923	515	24	pbpk	pbpk	NOUN
admet-923	515	25	modelling	model	VERB
admet-923	515	26	[	[	X
admet-923	515	27	120	120	NUM
admet-923	515	28	]	]	PUNCT
admet-923	515	29	(	(	PUNCT
admet-923	515	30	except	except	SCONJ
admet-923	515	31	for	for	ADP
admet-923	515	32	molecular	molecular	ADJ
admet-923	515	33	diffusion	diffusion	NOUN
admet-923	515	34	coefficients	coefficient	NOUN
admet-923	515	35	[	[	X
admet-923	515	36	156	156	NUM
admet-923	515	37	,	,	PUNCT
admet-923	515	38	157	157	NUM
admet-923	515	39	]	]	PUNCT
admet-923	515	40	)	)	PUNCT
admet-923	515	41	.	.	PUNCT
admet-923	516	1	(	(	PUNCT
admet-923	516	2	v	v	NOUN
admet-923	516	3	)	)	PUNCT
admet-923	516	4	hypothesis	hypothesis	NOUN
admet-923	516	5	generation	generation	NOUN
admet-923	516	6	the	the	DET
admet-923	516	7	peff	peff	NOUN
admet-923	516	8	value	value	NOUN
admet-923	516	9	is	be	AUX
admet-923	516	10	still	still	ADV
admet-923	516	11	not	not	PART
admet-923	516	12	identifiable	identifiable	ADJ
admet-923	516	13	after	after	ADP
admet-923	516	14	fixing	fix	VERB
admet-923	516	15	s	s	PROPN
admet-923	516	16	,	,	PUNCT
admet-923	516	17	vsi	vsi	PROPN
admet-923	516	18	,	,	PUNCT
admet-923	516	19	tsi	tsi	PROPN
admet-923	516	20	,	,	PUNCT
admet-923	516	21	rsi	rsi	PROPN
admet-923	516	22	,	,	PUNCT
admet-923	516	23	df	df	NOUN
admet-923	516	24	,	,	PUNCT
admet-923	516	25	cl	cl	NOUN
admet-923	516	26	,	,	PUNCT
admet-923	516	27	and	and	CCONJ
admet-923	516	28	fh	fh	PROPN
admet-923	516	29	.	.	PROPN
admet-923	516	30	hypothesis	hypothesis	NOUN
admet-923	516	31	generation	generation	NOUN
admet-923	516	32	is	be	AUX
admet-923	516	33	required	require	VERB
admet-923	516	34	to	to	PART
admet-923	516	35	estimate	estimate	VERB
admet-923	516	36	fg	fg	PRON
admet-923	516	37	[	[	X
admet-923	516	38	14	14	NUM
admet-923	516	39	]	]	PUNCT
admet-923	516	40	.	.	PUNCT
admet-923	517	1	hypothesis	hypothesis	NOUN
admet-923	517	2	generation	generation	NOUN
admet-923	517	3	may	may	AUX
admet-923	517	4	include	include	VERB
admet-923	517	5	ivive	ivive	ADJ
admet-923	517	6	,	,	PUNCT
admet-923	517	7	but	but	CCONJ
admet-923	517	8	in	in	ADP
admet-923	517	9	a	a	DET
admet-923	517	10	less	less	ADV
admet-923	517	11	qualitative	qualitative	ADJ
admet-923	517	12	manner	manner	NOUN
admet-923	517	13	.	.	PUNCT
admet-923	518	1	hypothesis	hypothesis	NOUN
admet-923	518	2	generation	generation	NOUN
admet-923	518	3	about	about	ADP
admet-923	518	4	the	the	DET
admet-923	518	5	negligibility	negligibility	NOUN
admet-923	518	6	of	of	ADP
admet-923	518	7	a	a	DET
admet-923	518	8	parameter	parameter	NOUN
admet-923	518	9	would	would	AUX
admet-923	518	10	be	be	AUX
admet-923	518	11	most	most	ADV
admet-923	518	12	credible	credible	ADJ
admet-923	518	13	and	and	CCONJ
admet-923	518	14	useful	useful	ADJ
admet-923	518	15	because	because	SCONJ
admet-923	518	16	it	it	PRON
admet-923	518	17	can	can	AUX
admet-923	518	18	reduce	reduce	VERB
admet-923	518	19	the	the	DET
admet-923	518	20	interference	interference	NOUN
admet-923	518	21	from	from	ADP
admet-923	518	22	the	the	DET
admet-923	518	23	parameter	parameter	NOUN
admet-923	518	24	for	for	ADP
admet-923	518	25	back	back	NOUN
admet-923	518	26	-	-	PUNCT
admet-923	518	27	calculation	calculation	NOUN
admet-923	518	28	.	.	PUNCT
admet-923	519	1	the	the	DET
admet-923	519	2	credibility	credibility	NOUN
admet-923	519	3	of	of	ADP
admet-923	519	4	a	a	DET
admet-923	519	5	hypothesis	hypothesis	NOUN
admet-923	519	6	can	can	AUX
admet-923	519	7	be	be	AUX
admet-923	519	8	improved	improve	VERB
admet-923	519	9	by	by	ADP
admet-923	519	10	combining	combine	VERB
admet-923	519	11	various	various	ADJ
admet-923	519	12	in	in	ADP
admet-923	519	13	vitro	vitro	X
admet-923	519	14	,	,	PUNCT
admet-923	519	15	preclinical	preclinical	ADJ
admet-923	519	16	in	in	ADP
admet-923	519	17	vivo	vivo	NOUN
admet-923	519	18	,	,	PUNCT
admet-923	519	19	and	and	CCONJ
admet-923	519	20	clinical	clinical	ADJ
admet-923	519	21	observations	observation	NOUN
admet-923	519	22	.	.	PUNCT
admet-923	520	1	for	for	ADP
admet-923	520	2	example	example	NOUN
admet-923	520	3	,	,	PUNCT
admet-923	520	4	when	when	SCONJ
admet-923	520	5	in	in	ADP
admet-923	520	6	vitro	vitro	X
admet-923	520	7	data	datum	NOUN
admet-923	520	8	suggest	suggest	VERB
admet-923	520	9	that	that	SCONJ
admet-923	520	10	a	a	DET
admet-923	520	11	drug	drug	NOUN
admet-923	520	12	is	be	AUX
admet-923	520	13	not	not	PART
admet-923	520	14	a	a	DET
admet-923	520	15	substrate	substrate	NOUN
admet-923	520	16	of	of	ADP
admet-923	520	17	intestinal	intestinal	ADJ
admet-923	520	18	metabolic	metabolic	NOUN
admet-923	520	19	enzymes	enzyme	NOUN
admet-923	520	20	,	,	PUNCT
admet-923	520	21	fg	fg	PROPN
admet-923	520	22	=	=	SYM
admet-923	520	23	1	1	NUM
admet-923	520	24	(	(	PUNCT
admet-923	520	25	no	no	DET
admet-923	520	26	gut	gut	NOUN
admet-923	520	27	wall	wall	NOUN
admet-923	520	28	metabolism	metabolism	NOUN
admet-923	520	29	)	)	PUNCT
admet-923	520	30	can	can	AUX
admet-923	520	31	be	be	AUX
admet-923	520	32	a	a	DET
admet-923	520	33	plausible	plausible	ADJ
admet-923	520	34	hypothesis	hypothesis	NOUN
admet-923	520	35	.	.	PUNCT
admet-923	521	1	low	low	ADJ
admet-923	521	2	intrinsic	intrinsic	ADJ
admet-923	521	3	hepatic	hepatic	ADJ
admet-923	521	4	clearance	clearance	NOUN
admet-923	521	5	(	(	PUNCT
admet-923	521	6	<	<	X
admet-923	521	7	100	100	NUM
admet-923	521	8	ml	ml	NOUN
admet-923	521	9	/	/	SYM
admet-923	521	10	min	min	NOUN
admet-923	521	11	/	/	SYM
admet-923	521	12	kg)[158	kg)[158	PROPN
admet-923	521	13	]	]	PUNCT
admet-923	521	14	,	,	PUNCT
admet-923	521	15	the	the	DET
admet-923	521	16	lack	lack	NOUN
admet-923	521	17	of	of	ADP
admet-923	521	18	metabolites	metabolite	NOUN
admet-923	521	19	,	,	PUNCT
admet-923	521	20	and	and	CCONJ
admet-923	521	21	the	the	DET
admet-923	521	22	lack	lack	NOUN
admet-923	521	23	of	of	ADP
admet-923	521	24	clinical	clinical	ADJ
admet-923	521	25	grapefruit	grapefruit	NOUN
admet-923	521	26	–	–	PUNCT
admet-923	521	27	drug	drug	NOUN
admet-923	521	28	interaction	interaction	NOUN
admet-923	521	29	can	can	AUX
admet-923	521	30	further	far	ADV
admet-923	521	31	support	support	VERB
admet-923	521	32	the	the	DET
admet-923	521	33	hypothesis	hypothesis	NOUN
admet-923	521	34	of	of	ADP
admet-923	521	35	fg	fg	PROPN
admet-923	521	36	=	=	PROPN
admet-923	521	37	1	1	NUM
admet-923	521	38	.	.	NUM
admet-923	521	39	3.9	3.9	NUM
admet-923	521	40	.	.	PUNCT
admet-923	522	1	a	a	DET
admet-923	522	2	good	good	ADJ
admet-923	522	3	example	example	NOUN
admet-923	522	4	of	of	ADP
admet-923	522	5	credible	credible	ADJ
admet-923	522	6	parameter	parameter	NOUN
admet-923	522	7	back	back	ADJ
admet-923	522	8	-	-	PUNCT
admet-923	522	9	calculation	calculation	NOUN
admet-923	522	10	sjögren	sjögren	PROPN
admet-923	522	11	et	et	PROPN
admet-923	522	12	al	al	PROPN
admet-923	522	13	.	.	PROPN
admet-923	522	14	reported	report	VERB
admet-923	522	15	that	that	SCONJ
admet-923	522	16	peff	peff	PROPN
admet-923	522	17	can	can	AUX
admet-923	522	18	be	be	AUX
admet-923	522	19	credibly	credibly	ADV
admet-923	522	20	identifiable	identifiable	ADJ
admet-923	522	21	by	by	ADP
admet-923	522	22	the	the	DET
admet-923	522	23	deconvolution	deconvolution	NOUN
admet-923	522	24	of	of	ADP
admet-923	522	25	the	the	DET
admet-923	522	26	cp	cp	PROPN
admet-923	522	27	time	time	NOUN
admet-923	522	28	profiles	profile	NOUN
admet-923	522	29	after	after	ADP
admet-923	522	30	intraintestinal	intraintestinal	ADJ
admet-923	522	31	bolus	bolus	PROPN
admet-923	522	32	administration	administration	NOUN
admet-923	522	33	as	as	ADP
admet-923	522	34	a	a	DET
admet-923	522	35	solution	solution	NOUN
admet-923	522	36	,	,	PUNCT
admet-923	522	37	using	use	VERB
admet-923	522	38	i.v	i.v	PROPN
admet-923	522	39	.	.	PUNCT
admet-923	522	40	disposition	disposition	NOUN
admet-923	522	41	data	datum	NOUN
admet-923	522	42	[	[	X
admet-923	522	43	151	151	NUM
admet-923	522	44	]	]	PUNCT
admet-923	522	45	.	.	PUNCT
admet-923	523	1	they	they	PRON
admet-923	523	2	pointed	point	VERB
admet-923	523	3	out	out	ADP
admet-923	523	4	that	that	SCONJ
admet-923	523	5	the	the	DET
admet-923	523	6	cp	cp	PROPN
admet-923	523	7	time	time	NOUN
admet-923	523	8	profiles	profile	NOUN
admet-923	523	9	after	after	SCONJ
admet-923	523	10	an	an	DET
admet-923	523	11	oral	oral	ADJ
admet-923	523	12	administration	administration	NOUN
admet-923	523	13	may	may	AUX
admet-923	523	14	not	not	PART
admet-923	523	15	be	be	AUX
admet-923	523	16	suitable	suitable	ADJ
admet-923	523	17	for	for	ADP
admet-923	523	18	peff	peff	NOUN
admet-923	523	19	estimation	estimation	NOUN
admet-923	523	20	due	due	ADP
admet-923	523	21	to	to	ADP
admet-923	523	22	possible	possible	ADJ
admet-923	523	23	interference	interference	NOUN
admet-923	523	24	of	of	ADP
admet-923	523	25	confounding	confound	VERB
admet-923	523	26	factors	factor	NOUN
admet-923	523	27	.	.	PUNCT
admet-923	524	1	they	they	PRON
admet-923	524	2	used	use	VERB
admet-923	524	3	a	a	DET
admet-923	524	4	solution	solution	NOUN
admet-923	524	5	formulation	formulation	NOUN
admet-923	524	6	to	to	PART
admet-923	524	7	eliminate	eliminate	VERB
admet-923	524	8	the	the	DET
admet-923	524	9	uncertainty	uncertainty	NOUN
admet-923	524	10	in	in	ADP
admet-923	524	11	s	s	PROPN
admet-923	524	12	,	,	PUNCT
admet-923	524	13	vsi	vsi	PROPN
admet-923	524	14	,	,	PUNCT
admet-923	524	15	and	and	CCONJ
admet-923	524	16	the	the	DET
admet-923	524	17	effect	effect	NOUN
admet-923	524	18	of	of	ADP
admet-923	524	19	dissolution	dissolution	NOUN
admet-923	524	20	processes	process	NOUN
admet-923	524	21	.	.	PUNCT
admet-923	525	1	intra	intra	ADJ
admet-923	525	2	-	-	ADJ
admet-923	525	3	intestinal	intestinal	ADJ
admet-923	525	4	administration	administration	NOUN
admet-923	525	5	was	be	AUX
admet-923	525	6	used	use	VERB
admet-923	525	7	to	to	PART
admet-923	525	8	eliminate	eliminate	VERB
admet-923	525	9	the	the	DET
admet-923	525	10	effect	effect	NOUN
admet-923	525	11	of	of	ADP
admet-923	525	12	gastric	gastric	ADJ
admet-923	525	13	emptying	emptying	NOUN
admet-923	525	14	.	.	PUNCT
admet-923	526	1	the	the	DET
admet-923	526	2	i.v	i.v	PROPN
admet-923	526	3	data	datum	NOUN
admet-923	526	4	was	be	AUX
admet-923	526	5	used	use	VERB
admet-923	526	6	to	to	PART
admet-923	526	7	calculate	calculate	VERB
admet-923	526	8	cl	cl	NOUN
admet-923	526	9	and	and	CCONJ
admet-923	526	10	fh	fh	PROPN
admet-923	526	11	.	.	PROPN
admet-923	526	12	hypothesis	hypothesis	NOUN
admet-923	526	13	generation	generation	NOUN
admet-923	526	14	was	be	AUX
admet-923	526	15	used	use	VERB
admet-923	526	16	for	for	ADP
admet-923	526	17	fg	fg	PROPN
admet-923	526	18	.	.	PUNCT
admet-923	527	1	the	the	DET
admet-923	527	2	basic	basic	ADJ
admet-923	527	3	concept	concept	NOUN
admet-923	527	4	of	of	ADP
admet-923	527	5	their	their	PRON
admet-923	527	6	approach	approach	NOUN
admet-923	527	7	is	be	AUX
admet-923	527	8	shown	show	VERB
admet-923	527	9	in	in	ADP
admet-923	527	10	figure	figure	NOUN
admet-923	527	11	8	8	NUM
admet-923	527	12	(	(	PUNCT
admet-923	527	13	they	they	PRON
admet-923	527	14	used	use	VERB
admet-923	527	15	the	the	DET
admet-923	527	16	deconvolution	deconvolution	NOUN
admet-923	527	17	method	method	NOUN
admet-923	527	18	,	,	PUNCT
admet-923	527	19	but	but	CCONJ
admet-923	527	20	it	it	PRON
admet-923	527	21	was	be	AUX
admet-923	527	22	simplified	simplify	VERB
admet-923	527	23	to	to	PART
admet-923	527	24	auc	auc	VERB
admet-923	527	25	calculation	calculation	NOUN
admet-923	527	26	to	to	PART
admet-923	527	27	explain	explain	VERB
admet-923	527	28	the	the	DET
admet-923	527	29	concept	concept	NOUN
admet-923	527	30	)	)	PUNCT
admet-923	527	31	.	.	PUNCT
admet-923	528	1	3.10	3.10	NUM
admet-923	528	2	.	.	PUNCT
admet-923	528	3	accumulation	accumulation	NOUN
admet-923	528	4	of	of	ADP
admet-923	528	5	errors	error	NOUN
admet-923	528	6	after	after	ADP
admet-923	528	7	parameter	parameter	NOUN
admet-923	528	8	back	back	NOUN
admet-923	528	9	-	-	PUNCT
admet-923	528	10	calculation	calculation	NOUN
admet-923	528	11	,	,	PUNCT
admet-923	528	12	the	the	DET
admet-923	528	13	simulation	simulation	NOUN
admet-923	528	14	curve	curve	NOUN
admet-923	528	15	would	would	AUX
admet-923	528	16	show	show	VERB
admet-923	528	17	perfect	perfect	ADJ
admet-923	528	18	fitting	fitting	ADJ
admet-923	528	19	to	to	ADP
admet-923	528	20	the	the	DET
admet-923	528	21	observed	observe	VERB
admet-923	528	22	cp	cp	NOUN
admet-923	528	23	time	time	NOUN
admet-923	528	24	data	datum	NOUN
admet-923	528	25	that	that	PRON
admet-923	528	26	had	have	AUX
admet-923	528	27	been	be	AUX
admet-923	528	28	used	use	VERB
admet-923	528	29	for	for	ADP
admet-923	528	30	parameter	parameter	NOUN
admet-923	528	31	back	back	ADJ
admet-923	528	32	-	-	PUNCT
admet-923	528	33	calculation	calculation	NOUN
admet-923	528	34	.	.	PUNCT
admet-923	529	1	however	however	ADV
admet-923	529	2	,	,	PUNCT
admet-923	529	3	this	this	DET
admet-923	529	4	perfect	perfect	ADJ
admet-923	529	5	fitting	fitting	NOUN
admet-923	529	6	does	do	AUX
admet-923	529	7	not	not	PART
admet-923	529	8	imply	imply	VERB
admet-923	529	9	the	the	DET
admet-923	529	10	validity	validity	NOUN
admet-923	529	11	of	of	ADP
admet-923	529	12	all	all	DET
admet-923	529	13	parameters	parameter	NOUN
admet-923	529	14	and	and	CCONJ
admet-923	529	15	model	model	NOUN
admet-923	529	16	equations	equation	NOUN
admet-923	529	17	.	.	PUNCT
admet-923	530	1	a	a	DET
admet-923	530	2	back	back	ADV
admet-923	530	3	-	-	PUNCT
admet-923	530	4	calculated	calculate	VERB
admet-923	530	5	parameter	parameter	NOUN
admet-923	530	6	inherits	inherit	VERB
admet-923	530	7	the	the	DET
admet-923	530	8	errors	error	NOUN
admet-923	530	9	of	of	ADP
admet-923	530	10	the	the	DET
admet-923	530	11	other	other	ADJ
admet-923	530	12	parameters	parameter	NOUN
admet-923	530	13	(	(	PUNCT
admet-923	530	14	see	see	VERB
admet-923	530	15	checkpoint	checkpoint	NOUN
admet-923	530	16	4	4	NUM
admet-923	530	17	)	)	PUNCT
admet-923	530	18	.	.	PUNCT
admet-923	531	1	in	in	ADP
admet-923	531	2	the	the	DET
admet-923	531	3	case	case	NOUN
admet-923	531	4	of	of	ADP
admet-923	531	5	eq	eq	PROPN
admet-923	531	6	.	.	PROPN
admet-923	531	7	6	6	NUM
admet-923	531	8	,	,	PUNCT
admet-923	531	9	the	the	DET
admet-923	531	10	errors	error	NOUN
admet-923	531	11	in	in	ADP
admet-923	531	12	nine	nine	NUM
admet-923	531	13	separately	separately	ADV
admet-923	531	14	fixed	fix	VERB
admet-923	531	15	parameters	parameter	NOUN
admet-923	531	16	(	(	PUNCT
admet-923	531	17	vsi	vsi	PROPN
admet-923	531	18	,	,	PUNCT
admet-923	531	19	tsi	tsi	PROPN
admet-923	531	20	,	,	PUNCT
admet-923	531	21	rsi	rsi	PROPN
admet-923	531	22	,	,	PUNCT
admet-923	531	23	df	df	PROPN
admet-923	531	24	,	,	PUNCT
admet-923	531	25	s	s	PROPN
admet-923	531	26	,	,	PUNCT
admet-923	531	27	cl	cl	NOUN
admet-923	531	28	,	,	PUNCT
admet-923	531	29	fg	fg	PROPN
admet-923	531	30	,	,	PUNCT
admet-923	531	31	fh	fh	PROPN
admet-923	531	32	,	,	PUNCT
admet-923	531	33	and	and	CCONJ
admet-923	531	34	clinical	clinical	ADJ
admet-923	531	35	auc	auc	NOUN
admet-923	531	36	)	)	PUNCT
admet-923	531	37	exponentially	exponentially	ADV
admet-923	531	38	accumulate	accumulate	VERB
admet-923	531	39	in	in	ADP
admet-923	531	40	peff	peff	PROPN
admet-923	531	41	(	(	PUNCT
admet-923	531	42	sections	section	NOUN
admet-923	531	43	2.2	2.2	NUM
admet-923	531	44	,	,	PUNCT
admet-923	531	45	2.8	2.8	NUM
admet-923	531	46	)	)	PUNCT
admet-923	531	47	.	.	PUNCT
admet-923	532	1	even	even	ADV
admet-923	532	2	if	if	SCONJ
admet-923	532	3	each	each	DET
admet-923	532	4	parameter	parameter	NOUN
admet-923	532	5	has	have	VERB
admet-923	532	6	only	only	ADV
admet-923	532	7	a	a	DET
admet-923	532	8	small	small	ADJ
admet-923	532	9	error	error	NOUN
admet-923	532	10	of	of	ADP
admet-923	532	11	20	20	NUM
admet-923	532	12	%	%	NOUN
admet-923	532	13	(	(	PUNCT
admet-923	532	14	1.2	1.2	NUM
admet-923	532	15	-	-	NUM
admet-923	532	16	fold	fold	ADJ
admet-923	532	17	)	)	PUNCT
admet-923	532	18	,	,	PUNCT
admet-923	532	19	the	the	DET
admet-923	532	20	total	total	ADJ
admet-923	532	21	error	error	NOUN
admet-923	532	22	can	can	AUX
admet-923	532	23	become	become	VERB
admet-923	532	24	5.2	5.2	NUM
admet-923	532	25	-	-	ADJ
admet-923	532	26	fold	fold	ADJ
admet-923	532	27	(=	(=	NOUN
admet-923	532	28	1.29	1.29	NUM
admet-923	532	29	)	)	PUNCT
admet-923	532	30	.	.	PUNCT
admet-923	533	1	to	to	PART
admet-923	533	2	back	back	VERB
admet-923	533	3	-	-	PUNCT
admet-923	533	4	calculate	calculate	NOUN
admet-923	533	5	peff	peff	NOUN
admet-923	533	6	within	within	ADP
admet-923	533	7	less	less	ADJ
admet-923	533	8	than	than	ADP
admet-923	533	9	20	20	NUM
admet-923	533	10	%	%	NOUN
admet-923	533	11	error	error	NOUN
admet-923	533	12	,	,	PUNCT
admet-923	533	13	each	each	DET
admet-923	533	14	parameter	parameter	NOUN
admet-923	533	15	must	must	AUX
admet-923	533	16	have	have	VERB
admet-923	533	17	less	less	ADJ
admet-923	533	18	than	than	ADP
admet-923	533	19	2	2	NUM
admet-923	533	20	%	%	NOUN
admet-923	533	21	error	error	NOUN
admet-923	533	22	.	.	PUNCT
admet-923	534	1	any	any	DET
admet-923	534	2	experimentalist	experimentalist	NOUN
admet-923	534	3	knows	know	VERB
admet-923	534	4	that	that	SCONJ
admet-923	534	5	this	this	PRON
admet-923	534	6	is	be	AUX
admet-923	534	7	not	not	PART
admet-923	534	8	possible	possible	ADJ
admet-923	534	9	.	.	PUNCT
admet-923	535	1	furthermore	furthermore	ADV
admet-923	535	2	,	,	PUNCT
admet-923	535	3	back	back	ADV
admet-923	535	4	-	-	PUNCT
admet-923	535	5	calculating	calculate	VERB
admet-923	535	6	one	one	NUM
admet-923	535	7	parameter	parameter	NOUN
admet-923	535	8	hides	hide	VERB
admet-923	535	9	the	the	DET
admet-923	535	10	errors	error	NOUN
admet-923	535	11	of	of	ADP
admet-923	535	12	the	the	DET
admet-923	535	13	other	other	ADJ
admet-923	535	14	parameters	parameter	NOUN
admet-923	535	15	and	and	CCONJ
admet-923	535	16	model	model	NOUN
admet-923	535	17	equations	equation	NOUN
admet-923	535	18	(	(	PUNCT
admet-923	535	19	section	section	NOUN
admet-923	535	20	3.4	3.4	NUM
admet-923	535	21	)	)	PUNCT
admet-923	535	22	.	.	PUNCT
admet-923	536	1	peff	peff	PROPN
admet-923	536	2	itself	itself	PRON
admet-923	536	3	can	can	AUX
admet-923	536	4	show	show	VERB
admet-923	536	5	high	high	ADJ
admet-923	536	6	inter	inter	ADJ
admet-923	536	7	-	-	ADJ
admet-923	536	8	subject	subject	ADJ
admet-923	536	9	variability	variability	NOUN
admet-923	536	10	[	[	X
admet-923	536	11	159	159	NUM
admet-923	536	12	]	]	PUNCT
admet-923	536	13	.	.	PUNCT
admet-923	537	1	https://doi.org/10.5599/admet.923	https://doi.org/10.5599/admet.923	X
admet-923	537	2	kiyohiko	kiyohiko	PROPN
admet-923	537	3	sugano	sugano	PROPN
admet-923	537	4	admet	admet	PROPN
admet-923	537	5	&	&	CCONJ
admet-923	537	6	dmpk	dmpk	PROPN
admet-923	537	7	9(2	9(2	NUM
admet-923	537	8	)	)	PUNCT
admet-923	537	9	(	(	PUNCT
admet-923	537	10	2021	2021	NUM
admet-923	537	11	)	)	PUNCT
admet-923	537	12	75	75	NUM
admet-923	537	13	-	-	SYM
admet-923	537	14	109	109	NUM
admet-923	537	15	94	94	NUM
admet-923	537	16	figure	figure	NOUN
admet-923	537	17	8	8	NUM
admet-923	537	18	.	.	PUNCT
admet-923	538	1	peff	peff	PROPN
admet-923	538	2	calculation	calculation	NOUN
admet-923	538	3	scheme	scheme	NOUN
admet-923	538	4	using	use	VERB
admet-923	538	5	a	a	DET
admet-923	538	6	set	set	NOUN
admet-923	538	7	of	of	ADP
admet-923	538	8	clinical	clinical	ADJ
admet-923	538	9	data	datum	NOUN
admet-923	538	10	,	,	PUNCT
admet-923	538	11	literature	literature	NOUN
admet-923	538	12	data	datum	NOUN
admet-923	538	13	,	,	PUNCT
admet-923	538	14	and	and	CCONJ
admet-923	538	15	hypothesis	hypothesis	NOUN
admet-923	538	16	generation	generation	NOUN
admet-923	538	17	.	.	PUNCT
admet-923	539	1	each	each	DET
admet-923	539	2	parameter	parameter	NOUN
admet-923	539	3	is	be	AUX
admet-923	539	4	fixed	fix	VERB
admet-923	539	5	step	step	NOUN
admet-923	539	6	-	-	PUNCT
admet-923	539	7	by	by	ADP
admet-923	539	8	-	-	PUNCT
admet-923	539	9	step	step	NOUN
admet-923	539	10	.	.	PUNCT
admet-923	540	1	the	the	DET
admet-923	540	2	parameters	parameter	NOUN
admet-923	540	3	after	after	ADP
admet-923	540	4	the	the	DET
admet-923	540	5	evaluation	evaluation	NOUN
admet-923	540	6	are	be	AUX
admet-923	540	7	moved	move	VERB
admet-923	540	8	to	to	ADP
admet-923	540	9	the	the	DET
admet-923	540	10	right	right	ADJ
admet-923	540	11	side	side	NOUN
admet-923	540	12	of	of	ADP
admet-923	540	13	the	the	DET
admet-923	540	14	equation	equation	NOUN
admet-923	540	15	and	and	CCONJ
admet-923	540	16	shown	show	VERB
admet-923	540	17	in	in	ADP
admet-923	540	18	bold	bold	ADJ
admet-923	540	19	type	type	NOUN
admet-923	540	20	.	.	PUNCT
admet-923	541	1	eq.6	eq.6	NOUN
admet-923	541	2	is	be	AUX
admet-923	541	3	used	use	VERB
admet-923	541	4	to	to	PART
admet-923	541	5	understand	understand	VERB
admet-923	541	6	the	the	DET
admet-923	541	7	concept	concept	NOUN
admet-923	541	8	of	of	ADP
admet-923	541	9	back	back	NOUN
admet-923	541	10	-	-	PUNCT
admet-923	541	11	calculation	calculation	NOUN
admet-923	541	12	.	.	PUNCT
admet-923	542	1	sjo	sjo	PROPN
admet-923	542	2	̈gren	̈gren	PROPN
admet-923	543	1	et	et	PROPN
admet-923	543	2	al	al	PROPN
admet-923	543	3	.	.	PROPN
admet-923	543	4	used	use	VERB
admet-923	543	5	the	the	DET
admet-923	543	6	deconvolution	deconvolution	NOUN
admet-923	543	7	method	method	NOUN
admet-923	543	8	[	[	X
admet-923	543	9	151	151	NUM
admet-923	543	10	]	]	PUNCT
admet-923	543	11	,	,	PUNCT
admet-923	543	12	but	but	CCONJ
admet-923	543	13	the	the	DET
admet-923	543	14	basic	basic	ADJ
admet-923	543	15	concept	concept	NOUN
admet-923	543	16	of	of	ADP
admet-923	543	17	parameter	parameter	NOUN
admet-923	543	18	identification	identification	NOUN
admet-923	543	19	is	be	AUX
admet-923	543	20	the	the	DET
admet-923	543	21	same	same	ADJ
admet-923	543	22	(	(	PUNCT
admet-923	543	23	the	the	DET
admet-923	543	24	deconvolution	deconvolution	NOUN
admet-923	543	25	method	method	NOUN
admet-923	543	26	can	can	AUX
admet-923	543	27	eliminate	eliminate	VERB
admet-923	543	28	the	the	DET
admet-923	543	29	uncertainty	uncertainty	NOUN
admet-923	543	30	in	in	ADP
admet-923	543	31	tsi	tsi	PROPN
admet-923	543	32	)	)	PUNCT
admet-923	543	33	.	.	PUNCT
admet-923	544	1	3.11	3.11	NUM
admet-923	544	2	.	.	PUNCT
admet-923	545	1	how	how	SCONJ
admet-923	545	2	to	to	PART
admet-923	545	3	validate	validate	VERB
admet-923	545	4	the	the	DET
admet-923	545	5	predictive	predictive	ADJ
admet-923	545	6	power	power	NOUN
admet-923	545	7	of	of	ADP
admet-923	545	8	a	a	DET
admet-923	545	9	pbpk	pbpk	ADJ
admet-923	545	10	model	model	NOUN
admet-923	545	11	after	after	ADP
admet-923	545	12	parameter	parameter	NOUN
admet-923	545	13	back	back	NOUN
admet-923	545	14	-	-	PUNCT
admet-923	545	15	calculation	calculation	NOUN
admet-923	545	16	in	in	ADP
admet-923	545	17	a	a	DET
admet-923	545	18	local	local	ADJ
admet-923	545	19	middle	middle	ADJ
admet-923	545	20	-	-	PUNCT
admet-923	545	21	out	out	ADP
admet-923	545	22	approach	approach	NOUN
admet-923	545	23	,	,	PUNCT
admet-923	545	24	the	the	DET
admet-923	545	25	predictive	predictive	ADJ
admet-923	545	26	power	power	NOUN
admet-923	545	27	needs	need	VERB
admet-923	545	28	to	to	PART
admet-923	545	29	be	be	AUX
admet-923	545	30	validated	validate	VERB
admet-923	545	31	for	for	ADP
admet-923	545	32	each	each	DET
admet-923	545	33	drug	drug	NOUN
admet-923	545	34	after	after	ADP
admet-923	545	35	parameter	parameter	NOUN
admet-923	545	36	back	back	NOUN
admet-923	545	37	-	-	PUNCT
admet-923	545	38	calculation	calculation	NOUN
admet-923	545	39	.	.	PUNCT
admet-923	546	1	the	the	DET
admet-923	546	2	parameter	parameter	NOUN
admet-923	546	3	back	back	ADV
admet-923	546	4	-	-	PUNCT
admet-923	546	5	calculated	calculate	VERB
admet-923	546	6	in	in	ADP
admet-923	546	7	one	one	NUM
admet-923	546	8	clinical	clinical	ADJ
admet-923	546	9	condition	condition	NOUN
admet-923	546	10	is	be	AUX
admet-923	546	11	not	not	PART
admet-923	546	12	necessarily	necessarily	ADV
admet-923	546	13	valid	valid	ADJ
admet-923	546	14	in	in	ADP
admet-923	546	15	the	the	DET
admet-923	546	16	other	other	ADJ
admet-923	546	17	clinical	clinical	ADJ
admet-923	546	18	condition	condition	NOUN
admet-923	546	19	(	(	PUNCT
admet-923	546	20	section	section	NOUN
admet-923	546	21	3.3	3.3	NUM
admet-923	546	22	,	,	PUNCT
admet-923	546	23	checkpoint	checkpoint	NOUN
admet-923	546	24	6	6	NUM
admet-923	546	25	)	)	PUNCT
admet-923	546	26	.	.	PUNCT
admet-923	547	1	the	the	DET
admet-923	547	2	predictive	predictive	ADJ
admet-923	547	3	power	power	NOUN
admet-923	547	4	of	of	ADP
admet-923	547	5	a	a	DET
admet-923	547	6	model	model	NOUN
admet-923	547	7	can	can	AUX
admet-923	547	8	not	not	PART
admet-923	547	9	be	be	AUX
admet-923	547	10	validated	validate	VERB
admet-923	547	11	by	by	ADP
admet-923	547	12	the	the	DET
admet-923	547	13	same	same	ADJ
admet-923	547	14	data	datum	NOUN
admet-923	547	15	used	use	VERB
admet-923	547	16	for	for	ADP
admet-923	547	17	parameter	parameter	NOUN
admet-923	547	18	back	back	ADJ
admet-923	547	19	-	-	PUNCT
admet-923	547	20	calculation	calculation	NOUN
admet-923	547	21	,	,	PUNCT
admet-923	547	22	because	because	SCONJ
admet-923	547	23	it	it	PRON
admet-923	547	24	is	be	AUX
admet-923	547	25	self	self	NOUN
admet-923	547	26	-	-	PUNCT
admet-923	547	27	referencing	referencing	NOUN
admet-923	547	28	.	.	PUNCT
admet-923	548	1	therefore	therefore	ADV
admet-923	548	2	,	,	PUNCT
admet-923	548	3	the	the	DET
admet-923	548	4	predictive	predictive	ADJ
admet-923	548	5	power	power	NOUN
admet-923	548	6	needs	need	VERB
admet-923	548	7	to	to	PART
admet-923	548	8	be	be	AUX
admet-923	548	9	validated	validate	VERB
admet-923	548	10	using	use	VERB
admet-923	548	11	other	other	ADJ
admet-923	548	12	clinical	clinical	ADJ
admet-923	548	13	pk	pk	NOUN
admet-923	548	14	studies	study	NOUN
admet-923	548	15	of	of	ADP
admet-923	548	16	the	the	DET
admet-923	548	17	context	context	NOUN
admet-923	548	18	of	of	ADP
admet-923	548	19	use	use	NOUN
admet-923	548	20	(	(	PUNCT
admet-923	548	21	cou	cou	NOUN
admet-923	548	22	)	)	PUNCT
admet-923	548	23	(	(	PUNCT
admet-923	548	24	“	"	PUNCT
admet-923	548	25	cross	cross	ADJ
admet-923	548	26	-	-	ADJ
admet-923	548	27	validation	validation	NOUN
admet-923	548	28	”	"	PUNCT
admet-923	548	29	)	)	PUNCT
admet-923	548	30	.	.	PUNCT
admet-923	549	1	the	the	DET
admet-923	549	2	pk	pk	NOUN
admet-923	549	3	data	datum	NOUN
admet-923	549	4	under	under	ADP
admet-923	549	5	clinical	clinical	ADJ
admet-923	549	6	conditions	condition	NOUN
admet-923	549	7	where	where	SCONJ
admet-923	549	8	some	some	PRON
admet-923	549	9	of	of	ADP
admet-923	549	10	the	the	DET
admet-923	549	11	same	same	ADJ
admet-923	549	12	pathways	pathway	NOUN
admet-923	549	13	in	in	ADP
admet-923	549	14	the	the	DET
admet-923	549	15	system	system	NOUN
admet-923	549	16	are	be	AUX
admet-923	549	17	perturbed	perturb	VERB
admet-923	549	18	as	as	ADP
admet-923	549	19	in	in	ADP
admet-923	549	20	the	the	DET
admet-923	549	21	cou	cou	NOUN
admet-923	549	22	can	can	AUX
admet-923	549	23	be	be	AUX
admet-923	549	24	employed	employ	VERB
admet-923	549	25	for	for	ADP
admet-923	549	26	validation	validation	NOUN
admet-923	549	27	[	[	X
admet-923	549	28	10,21	10,21	NUM
admet-923	549	29	]	]	PUNCT
admet-923	549	30	.	.	PUNCT
admet-923	550	1	in	in	ADP
admet-923	550	2	the	the	DET
admet-923	550	3	case	case	NOUN
admet-923	550	4	of	of	ADP
admet-923	550	5	food	food	NOUN
admet-923	550	6	effect	effect	NOUN
admet-923	550	7	prediction	prediction	NOUN
admet-923	550	8	,	,	PUNCT
admet-923	550	9	the	the	DET
admet-923	550	10	optimized	optimize	VERB
admet-923	550	11	model	model	NOUN
admet-923	550	12	should	should	AUX
admet-923	550	13	be	be	AUX
admet-923	550	14	validated	validate	VERB
admet-923	550	15	by	by	ADP
admet-923	550	16	the	the	DET
admet-923	550	17	cp	cp	PROPN
admet-923	550	18	time	time	NOUN
admet-923	550	19	data	datum	NOUN
admet-923	550	20	under	under	ADP
admet-923	550	21	a	a	DET
admet-923	550	22	clinical	clinical	ADJ
admet-923	550	23	condition	condition	NOUN
admet-923	550	24	in	in	ADP
admet-923	550	25	which	which	PRON
admet-923	550	26	the	the	DET
admet-923	550	27	pathways	pathway	NOUN
admet-923	550	28	of	of	ADP
admet-923	550	29	oral	oral	ADJ
admet-923	550	30	absorption	absorption	NOUN
admet-923	550	31	are	be	AUX
admet-923	550	32	perturbed	perturb	VERB
admet-923	550	33	by	by	ADP
admet-923	550	34	the	the	DET
admet-923	550	35	same	same	ADJ
admet-923	550	36	factor	factor	NOUN
admet-923	550	37	for	for	ADP
admet-923	550	38	the	the	DET
admet-923	550	39	food	food	NOUN
admet-923	550	40	effect	effect	NOUN
admet-923	550	41	.	.	PUNCT
admet-923	551	1	in	in	ADP
admet-923	551	2	other	other	ADJ
admet-923	551	3	words	word	NOUN
admet-923	551	4	,	,	PUNCT
admet-923	551	5	the	the	DET
admet-923	551	6	food	food	NOUN
admet-923	551	7	effect	effect	NOUN
admet-923	551	8	prediction	prediction	NOUN
admet-923	551	9	must	must	AUX
admet-923	551	10	be	be	AUX
admet-923	551	11	validated	validate	VERB
admet-923	551	12	by	by	ADP
admet-923	551	13	a	a	DET
admet-923	551	14	clinical	clinical	ADJ
admet-923	551	15	food	food	NOUN
admet-923	551	16	effect	effect	NOUN
admet-923	551	17	study	study	NOUN
admet-923	551	18	.	.	PUNCT
admet-923	552	1	the	the	DET
admet-923	552	2	clinical	clinical	ADJ
admet-923	552	3	pk	pk	NOUN
admet-923	552	4	data	datum	NOUN
admet-923	552	5	in	in	ADP
admet-923	552	6	the	the	DET
admet-923	552	7	same	same	ADJ
admet-923	552	8	clinical	clinical	ADJ
admet-923	552	9	condition	condition	NOUN
admet-923	552	10	can	can	AUX
admet-923	552	11	not	not	PART
admet-923	552	12	be	be	AUX
admet-923	552	13	used	use	VERB
admet-923	552	14	for	for	ADP
admet-923	552	15	validation	validation	NOUN
admet-923	552	16	,	,	PUNCT
admet-923	552	17	even	even	ADV
admet-923	552	18	if	if	SCONJ
admet-923	552	19	it	it	PRON
admet-923	552	20	is	be	AUX
admet-923	552	21	independently	independently	ADV
admet-923	552	22	determined	determine	VERB
admet-923	552	23	,	,	PUNCT
admet-923	552	24	because	because	SCONJ
admet-923	552	25	the	the	DET
admet-923	552	26	cp	cp	PROPN
admet-923	552	27	time	time	NOUN
admet-923	552	28	profiles	profile	NOUN
admet-923	552	29	are	be	AUX
admet-923	552	30	expected	expect	VERB
admet-923	552	31	to	to	PART
admet-923	552	32	be	be	AUX
admet-923	552	33	similar	similar	ADJ
admet-923	552	34	under	under	ADP
admet-923	552	35	the	the	DET
admet-923	552	36	same	same	ADJ
admet-923	552	37	clinical	clinical	ADJ
admet-923	552	38	condition	condition	NOUN
admet-923	552	39	(	(	PUNCT
admet-923	552	40	this	this	PRON
admet-923	552	41	is	be	AUX
admet-923	552	42	a	a	DET
admet-923	552	43	kind	kind	NOUN
admet-923	552	44	of	of	ADP
admet-923	552	45	“	"	PUNCT
admet-923	552	46	leakage	leakage	NOUN
admet-923	552	47	”	"	PUNCT
admet-923	552	48	in	in	ADP
admet-923	552	49	the	the	DET
admet-923	552	50	cross	cross	ADJ
admet-923	552	51	-	-	ADJ
admet-923	552	52	validation	validation	ADJ
admet-923	552	53	process	process	NOUN
admet-923	552	54	)	)	PUNCT
admet-923	552	55	.	.	PUNCT
admet-923	553	1	multiple	multiple	ADJ
admet-923	553	2	-	-	PUNCT
admet-923	553	3	dose	dose	VERB
admet-923	553	4	pk	pk	NOUN
admet-923	553	5	data	datum	NOUN
admet-923	553	6	under	under	ADP
admet-923	553	7	the	the	DET
admet-923	553	8	same	same	ADJ
admet-923	553	9	clinical	clinical	ADJ
admet-923	553	10	condition	condition	NOUN
admet-923	553	11	can	can	AUX
admet-923	553	12	not	not	PART
admet-923	553	13	be	be	AUX
admet-923	553	14	used	use	VERB
admet-923	553	15	for	for	ADP
admet-923	553	16	validation	validation	NOUN
admet-923	553	17	(	(	PUNCT
admet-923	553	18	unless	unless	SCONJ
admet-923	553	19	the	the	DET
admet-923	553	20	context	context	NOUN
admet-923	553	21	of	of	ADP
admet-923	553	22	use	use	NOUN
admet-923	553	23	is	be	AUX
admet-923	553	24	the	the	DET
admet-923	553	25	prediction	prediction	NOUN
admet-923	553	26	of	of	ADP
admet-923	553	27	metabolic	metabolic	ADJ
admet-923	553	28	enzyme	enzyme	NOUN
admet-923	553	29	induction	induction	NOUN
admet-923	553	30	or	or	CCONJ
admet-923	553	31	mechanism	mechanism	NOUN
admet-923	553	32	-	-	PUNCT
admet-923	553	33	based	base	VERB
admet-923	553	34	inhibition	inhibition	NOUN
admet-923	553	35	in	in	ADP
admet-923	553	36	the	the	DET
admet-923	553	37	intestine	intestine	NOUN
admet-923	553	38	after	after	ADP
admet-923	553	39	multiple	multiple	ADJ
admet-923	553	40	-	-	PUNCT
admet-923	553	41	dose	dose	NOUN
admet-923	553	42	pk	pk	NOUN
admet-923	553	43	)	)	PUNCT
admet-923	553	44	.	.	PUNCT
admet-923	554	1	3.12	3.12	NUM
admet-923	554	2	.	.	PUNCT
admet-923	554	3	“	"	PUNCT
admet-923	554	4	confirm	confirm	VERB
admet-923	554	5	and	and	CCONJ
admet-923	554	6	refine	refine	VERB
admet-923	554	7	“	"	PUNCT
admet-923	554	8	strategy	strategy	NOUN
admet-923	554	9	in	in	ADP
admet-923	554	10	drug	drug	NOUN
admet-923	554	11	discovery	discovery	NOUN
admet-923	554	12	and	and	CCONJ
admet-923	554	13	development	development	NOUN
admet-923	554	14	the	the	DET
admet-923	554	15	quality	quality	NOUN
admet-923	554	16	and	and	CCONJ
admet-923	554	17	quantity	quantity	NOUN
admet-923	554	18	of	of	ADP
admet-923	554	19	experimental	experimental	ADJ
admet-923	554	20	data	datum	NOUN
admet-923	554	21	available	available	ADJ
admet-923	554	22	for	for	ADP
admet-923	554	23	pbpk	pbpk	NOUN
admet-923	554	24	modelling	modelling	NOUN
admet-923	554	25	increase	increase	NOUN
admet-923	554	26	as	as	ADP
admet-923	554	27	a	a	DET
admet-923	554	28	research	research	NOUN
admet-923	554	29	project	project	NOUN
admet-923	554	30	proceeds	proceed	NOUN
admet-923	554	31	in	in	ADP
admet-923	554	32	drug	drug	NOUN
admet-923	554	33	discovery	discovery	NOUN
admet-923	554	34	and	and	CCONJ
admet-923	554	35	development	development	NOUN
admet-923	554	36	.	.	PUNCT
admet-923	555	1	therefore	therefore	ADV
admet-923	555	2	,	,	PUNCT
admet-923	555	3	it	it	PRON
admet-923	555	4	would	would	AUX
admet-923	555	5	be	be	AUX
admet-923	555	6	beneficial	beneficial	ADJ
admet-923	555	7	to	to	PART
admet-923	555	8	utilize	utilize	VERB
admet-923	555	9	these	these	DET
admet-923	555	10	data	datum	NOUN
admet-923	555	11	for	for	ADP
admet-923	555	12	pbpk	pbpk	NOUN
admet-923	555	13	modelling	modelling	NOUN
admet-923	555	14	(	(	PUNCT
admet-923	555	15	section	section	NOUN
admet-923	555	16	2.8	2.8	NUM
admet-923	555	17	)	)	PUNCT
admet-923	555	18	.	.	PUNCT
admet-923	556	1	each	each	DET
admet-923	556	2	module	module	NOUN
admet-923	556	3	in	in	ADP
admet-923	556	4	an	an	DET
admet-923	556	5	oa	oa	PROPN
admet-923	556	6	pbpk	pbpk	PROPN
admet-923	556	7	model	model	NOUN
admet-923	556	8	can	can	AUX
admet-923	556	9	be	be	AUX
admet-923	556	10	confirmed	confirm	VERB
admet-923	556	11	by	by	ADP
admet-923	556	12	comparison	comparison	NOUN
admet-923	556	13	with	with	ADP
admet-923	556	14	corresponding	correspond	VERB
admet-923	556	15	in	in	ADP
admet-923	556	16	vitro	vitro	X
admet-923	556	17	experimental	experimental	ADJ
admet-923	556	18	data	datum	NOUN
admet-923	556	19	covering	cover	VERB
admet-923	556	20	a	a	DET
admet-923	556	21	wider	wide	ADJ
admet-923	556	22	range	range	NOUN
admet-923	556	23	than	than	ADP
admet-923	556	24	in	in	ADP
admet-923	556	25	vivo	vivo	ADJ
admet-923	556	26	conditions	condition	NOUN
admet-923	556	27	.	.	PUNCT
admet-923	557	1	for	for	ADP
admet-923	557	2	example	example	NOUN
admet-923	557	3	,	,	PUNCT
admet-923	557	4	the	the	DET
admet-923	557	5	solubility	solubility	NOUN
admet-923	557	6	model	model	NOUN
admet-923	557	7	should	should	AUX
admet-923	557	8	be	be	AUX
admet-923	557	9	validated	validate	VERB
admet-923	557	10	by	by	ADP
admet-923	557	11	an	an	DET
admet-923	557	12	experimental	experimental	ADJ
admet-923	557	13	ph	ph	ADJ
admet-923	557	14	-	-	PUNCT
admet-923	557	15	solubility	solubility	NOUN
admet-923	557	16	profile	profile	NOUN
admet-923	557	17	in	in	ADP
admet-923	557	18	the	the	DET
admet-923	557	19	range	range	NOUN
admet-923	557	20	of	of	ADP
admet-923	557	21	ph	ph	PROPN
admet-923	557	22	1.0	1.0	NUM
admet-923	557	23	to	to	PART
admet-923	557	24	8.0	8.0	NUM
admet-923	557	25	to	to	PART
admet-923	557	26	cover	cover	VERB
admet-923	557	27	in	in	ADP
admet-923	557	28	vivo	vivo	ADJ
admet-923	557	29	gastrointestinal	gastrointestinal	ADJ
admet-923	557	30	conditions	condition	NOUN
admet-923	557	31	.	.	PUNCT
admet-923	558	1	the	the	DET
admet-923	558	2	dissolution	dissolution	NOUN
admet-923	558	3	model	model	NOUN
admet-923	558	4	(	(	PUNCT
admet-923	558	5	the	the	DET
admet-923	558	6	nernst	nernst	PROPN
admet-923	558	7	-	-	PUNCT
admet-923	558	8	noyes	noyes	PROPN
admet-923	558	9	-	-	PUNCT
admet-923	558	10	whitney	whitney	PROPN
admet-923	558	11	equation	equation	NOUN
admet-923	558	12	)	)	PUNCT
admet-923	558	13	can	can	AUX
admet-923	558	14	be	be	AUX
admet-923	558	15	confirmed	confirm	VERB
admet-923	558	16	admet	admet	PROPN
admet-923	558	17	&	&	CCONJ
admet-923	558	18	dmpk	dmpk	PROPN
admet-923	558	19	9(2	9(2	NUM
admet-923	558	20	)	)	PUNCT
admet-923	558	21	(	(	PUNCT
admet-923	558	22	2021	2021	NUM
admet-923	558	23	)	)	PUNCT
admet-923	558	24	75	75	NUM
admet-923	558	25	-	-	SYM
admet-923	558	26	109	109	NUM
admet-923	558	27	lost	lose	VERB
admet-923	558	28	in	in	ADP
admet-923	558	29	modelling	modelling	NOUN
admet-923	558	30	and	and	CCONJ
admet-923	558	31	simulation	simulation	NOUN
admet-923	558	32	?	?	PUNCT
admet-923	559	1	doi	doi	NOUN
admet-923	559	2	:	:	PUNCT
admet-923	559	3	https:/doi.org/10.5599	https:/doi.org/10.5599	PROPN
admet-923	559	4	/	/	SYM
admet-923	559	5	admet.923	admet.923	PROPN
admet-923	559	6	95	95	NUM
admet-923	559	7	by	by	ADP
admet-923	559	8	comparison	comparison	NOUN
admet-923	559	9	with	with	ADP
admet-923	559	10	dissolution	dissolution	NOUN
admet-923	559	11	test	test	NOUN
admet-923	559	12	data	datum	NOUN
admet-923	559	13	.	.	PUNCT
admet-923	560	1	if	if	SCONJ
admet-923	560	2	the	the	DET
admet-923	560	3	prediction	prediction	NOUN
admet-923	560	4	result	result	NOUN
admet-923	560	5	deviated	deviate	VERB
admet-923	560	6	from	from	ADP
admet-923	560	7	the	the	DET
admet-923	560	8	experimental	experimental	ADJ
admet-923	560	9	observation	observation	NOUN
admet-923	560	10	,	,	PUNCT
admet-923	560	11	an	an	DET
admet-923	560	12	empirical	empirical	ADJ
admet-923	560	13	correction	correction	NOUN
admet-923	560	14	parameter	parameter	NOUN
admet-923	560	15	can	can	AUX
admet-923	560	16	be	be	AUX
admet-923	560	17	introduced	introduce	VERB
admet-923	560	18	,	,	PUNCT
admet-923	560	19	like	like	ADP
admet-923	560	20	the	the	DET
admet-923	560	21	z	z	NOUN
admet-923	560	22	factor	factor	NOUN
admet-923	560	23	for	for	ADP
admet-923	560	24	each	each	DET
admet-923	560	25	dissolution	dissolution	ADJ
admet-923	560	26	condition	condition	NOUN
admet-923	561	1	[	[	X
admet-923	561	2	81	81	NUM
admet-923	561	3	]	]	PUNCT
admet-923	561	4	.	.	PUNCT
admet-923	562	1	similarly	similarly	ADV
admet-923	562	2	,	,	PUNCT
admet-923	562	3	in	in	ADP
admet-923	562	4	vivo	vivo	NOUN
admet-923	562	5	animal	animal	NOUN
admet-923	562	6	pk	pk	NOUN
admet-923	562	7	data	datum	NOUN
admet-923	562	8	can	can	AUX
admet-923	562	9	be	be	AUX
admet-923	562	10	used	use	VERB
admet-923	562	11	to	to	PART
admet-923	562	12	inform	inform	VERB
admet-923	562	13	the	the	DET
admet-923	562	14	confidence	confidence	NOUN
admet-923	562	15	level	level	NOUN
admet-923	562	16	of	of	ADP
admet-923	562	17	a	a	DET
admet-923	562	18	pbpk	pbpk	ADJ
admet-923	562	19	model	model	NOUN
admet-923	562	20	.	.	PUNCT
admet-923	563	1	however	however	ADV
admet-923	563	2	,	,	PUNCT
admet-923	563	3	in	in	ADP
admet-923	563	4	this	this	DET
admet-923	563	5	case	case	NOUN
admet-923	563	6	,	,	PUNCT
admet-923	563	7	the	the	DET
admet-923	563	8	refinement	refinement	NOUN
admet-923	563	9	(	(	PUNCT
admet-923	563	10	back	back	NOUN
admet-923	563	11	-	-	PUNCT
admet-923	563	12	calculation	calculation	NOUN
admet-923	563	13	)	)	PUNCT
admet-923	563	14	process	process	NOUN
admet-923	563	15	requires	require	VERB
admet-923	563	16	the	the	DET
admet-923	563	17	same	same	ADJ
admet-923	563	18	cautions	caution	NOUN
admet-923	563	19	as	as	ADP
admet-923	563	20	the	the	DET
admet-923	563	21	local	local	ADJ
admet-923	563	22	middle	middle	ADJ
admet-923	563	23	-	-	PUNCT
admet-923	563	24	out	out	ADP
admet-923	563	25	approach	approach	NOUN
admet-923	563	26	.	.	PUNCT
admet-923	564	1	in	in	ADP
admet-923	564	2	addition	addition	NOUN
admet-923	564	3	,	,	PUNCT
admet-923	564	4	there	there	PRON
admet-923	564	5	may	may	AUX
admet-923	564	6	be	be	AUX
admet-923	564	7	species	species	NOUN
admet-923	564	8	differences	difference	NOUN
admet-923	564	9	in	in	ADP
admet-923	564	10	the	the	DET
admet-923	564	11	back	back	ADV
admet-923	564	12	-	-	PUNCT
admet-923	564	13	calculated	calculate	VERB
admet-923	564	14	parameter	parameter	NOUN
admet-923	564	15	.	.	PUNCT
admet-923	565	1	first	first	ADJ
admet-923	565	2	-	-	PUNCT
admet-923	565	3	in	in	ADP
admet-923	565	4	-	-	PUNCT
admet-923	565	5	human	human	ADJ
admet-923	565	6	pk	pk	NOUN
admet-923	565	7	data	datum	NOUN
admet-923	565	8	can	can	AUX
admet-923	565	9	be	be	AUX
admet-923	565	10	used	use	VERB
admet-923	565	11	to	to	PART
admet-923	565	12	inform	inform	VERB
admet-923	565	13	the	the	DET
admet-923	565	14	confidence	confidence	NOUN
admet-923	565	15	level	level	NOUN
admet-923	565	16	of	of	ADP
admet-923	565	17	a	a	DET
admet-923	565	18	pbpk	pbpk	ADJ
admet-923	565	19	model	model	NOUN
admet-923	565	20	in	in	ADP
admet-923	565	21	humans	human	NOUN
admet-923	565	22	.	.	PUNCT
admet-923	566	1	the	the	DET
admet-923	566	2	pk	pk	NOUN
admet-923	566	3	data	datum	NOUN
admet-923	566	4	at	at	ADP
admet-923	566	5	a	a	DET
admet-923	566	6	low	low	ADJ
admet-923	566	7	dose	dose	NOUN
admet-923	566	8	(	(	PUNCT
admet-923	566	9	dose	dose	NOUN
admet-923	566	10	number	number	NOUN
admet-923	566	11	<	<	X
admet-923	566	12	<	<	X
admet-923	566	13	1	1	NUM
admet-923	566	14	)	)	PUNCT
admet-923	566	15	can	can	AUX
admet-923	566	16	be	be	AUX
admet-923	566	17	used	use	VERB
admet-923	566	18	to	to	PART
admet-923	566	19	evaluate	evaluate	VERB
admet-923	566	20	the	the	DET
admet-923	566	21	oral	oral	ADJ
admet-923	566	22	absorption	absorption	NOUN
admet-923	566	23	process	process	NOUN
admet-923	566	24	without	without	ADP
admet-923	566	25	interference	interference	NOUN
admet-923	566	26	from	from	ADP
admet-923	566	27	the	the	DET
admet-923	566	28	dissolution	dissolution	NOUN
admet-923	566	29	rate	rate	NOUN
admet-923	566	30	and	and	CCONJ
admet-923	566	31	solubility	solubility	NOUN
admet-923	566	32	.	.	PUNCT
admet-923	567	1	in	in	ADP
admet-923	567	2	the	the	DET
admet-923	567	3	case	case	NOUN
admet-923	567	4	of	of	ADP
admet-923	567	5	high	high	ADJ
admet-923	567	6	permeability	permeability	NOUN
admet-923	567	7	drugs	drug	NOUN
admet-923	567	8	,	,	PUNCT
admet-923	567	9	the	the	DET
admet-923	567	10	low	low	ADJ
admet-923	567	11	dose	dose	PROPN
admet-923	567	12	pk	pk	NOUN
admet-923	567	13	data	datum	NOUN
admet-923	567	14	may	may	AUX
admet-923	567	15	provide	provide	VERB
admet-923	567	16	information	information	NOUN
admet-923	567	17	regarding	regard	VERB
admet-923	567	18	systemic	systemic	ADJ
admet-923	567	19	clearance	clearance	NOUN
admet-923	567	20	and	and	CCONJ
admet-923	567	21	volume	volume	NOUN
admet-923	567	22	of	of	ADP
admet-923	567	23	distribution	distribution	NOUN
admet-923	567	24	to	to	ADP
admet-923	567	25	some	some	DET
admet-923	567	26	extent	extent	NOUN
admet-923	567	27	(	(	PUNCT
admet-923	567	28	but	but	CCONJ
admet-923	567	29	i.v	i.v	PROPN
admet-923	567	30	.	.	PROPN
admet-923	568	1	pk	pk	NOUN
admet-923	568	2	data	datum	NOUN
admet-923	568	3	is	be	AUX
admet-923	568	4	preferable	preferable	ADJ
admet-923	568	5	)	)	PUNCT
admet-923	568	6	.	.	PUNCT
admet-923	569	1	the	the	DET
admet-923	569	2	confidence	confidence	NOUN
admet-923	569	3	level	level	NOUN
admet-923	569	4	of	of	ADP
admet-923	569	5	solubility	solubility	NOUN
admet-923	569	6	and	and	CCONJ
admet-923	569	7	permeability	permeability	NOUN
admet-923	569	8	values	value	NOUN
admet-923	569	9	(	(	PUNCT
admet-923	569	10	as	as	ADP
admet-923	569	11	pn	pn	PROPN
admet-923	569	12	/	/	SYM
admet-923	569	13	do	do	VERB
admet-923	569	14	,	,	PUNCT
admet-923	569	15	eq	eq	NOUN
admet-923	569	16	.	.	NOUN
admet-923	569	17	2	2	NUM
admet-923	569	18	)	)	PUNCT
admet-923	569	19	may	may	AUX
admet-923	569	20	also	also	ADV
admet-923	569	21	be	be	AUX
admet-923	569	22	evaluated	evaluate	VERB
admet-923	569	23	by	by	ADP
admet-923	569	24	the	the	DET
admet-923	569	25	dose	dose	NOUN
admet-923	569	26	sub	sub	NOUN
admet-923	569	27	-	-	NOUN
admet-923	569	28	proportionality	proportionality	NOUN
admet-923	569	29	of	of	ADP
admet-923	569	30	auc	auc	NOUN
admet-923	569	31	(	(	PUNCT
admet-923	569	32	so	so	SCONJ
admet-923	569	33	that	that	DET
admet-923	569	34	relative	relative	ADJ
admet-923	569	35	bioavailability	bioavailability	NOUN
admet-923	569	36	between	between	ADP
admet-923	569	37	low	low	ADJ
admet-923	569	38	and	and	CCONJ
admet-923	569	39	high	high	ADJ
admet-923	569	40	doses	dose	NOUN
admet-923	569	41	)	)	PUNCT
admet-923	569	42	.	.	PUNCT
admet-923	570	1	however	however	ADV
admet-923	570	2	,	,	PUNCT
admet-923	570	3	as	as	SCONJ
admet-923	570	4	discussed	discuss	VERB
admet-923	570	5	above	above	ADV
admet-923	570	6	,	,	PUNCT
admet-923	570	7	it	it	PRON
admet-923	570	8	is	be	AUX
admet-923	570	9	not	not	PART
admet-923	570	10	easy	easy	ADJ
admet-923	570	11	to	to	PART
admet-923	570	12	accurately	accurately	ADV
admet-923	570	13	back	back	VERB
admet-923	570	14	-	-	PUNCT
admet-923	570	15	calculate	calculate	NOUN
admet-923	570	16	(	(	PUNCT
admet-923	570	17	refine	refine	PROPN
admet-923	570	18	)	)	PUNCT
admet-923	570	19	a	a	DET
admet-923	570	20	parameter	parameter	NOUN
admet-923	570	21	from	from	ADP
admet-923	570	22	in	in	ADP
admet-923	570	23	vivo	vivo	NOUN
admet-923	570	24	oral	oral	ADJ
admet-923	570	25	pk	pk	NOUN
admet-923	570	26	data	datum	NOUN
admet-923	570	27	.	.	PUNCT
admet-923	571	1	extreme	extreme	ADJ
admet-923	571	2	caution	caution	NOUN
admet-923	571	3	should	should	AUX
admet-923	571	4	be	be	AUX
admet-923	571	5	exercised	exercise	VERB
admet-923	571	6	when	when	SCONJ
admet-923	571	7	using	use	VERB
admet-923	571	8	a	a	DET
admet-923	571	9	middle	middle	ADJ
admet-923	571	10	-	-	PUNCT
admet-923	571	11	out	out	ADP
admet-923	571	12	approach	approach	NOUN
admet-923	571	13	.	.	PUNCT
admet-923	572	1	3.13	3.13	NUM
admet-923	572	2	.	.	PUNCT
admet-923	573	1	what	what	PRON
admet-923	573	2	is	be	AUX
admet-923	573	3	the	the	DET
admet-923	573	4	difference	difference	NOUN
admet-923	573	5	between	between	ADP
admet-923	573	6	metabolic	metabolic	NOUN
admet-923	573	7	ddi	ddi	NOUN
admet-923	573	8	and	and	CCONJ
admet-923	573	9	food	food	NOUN
admet-923	573	10	effect	effect	NOUN
admet-923	573	11	predictions	prediction	NOUN
admet-923	573	12	?	?	PUNCT
admet-923	574	1	a	a	DET
admet-923	574	2	local	local	ADJ
admet-923	574	3	middle	middle	ADJ
admet-923	574	4	-	-	PUNCT
admet-923	574	5	out	out	ADP
admet-923	574	6	approach	approach	NOUN
admet-923	574	7	has	have	AUX
admet-923	574	8	been	be	AUX
admet-923	574	9	successfully	successfully	ADV
admet-923	574	10	used	use	VERB
admet-923	574	11	to	to	PART
admet-923	574	12	predict	predict	VERB
admet-923	574	13	metabolic	metabolic	NOUN
admet-923	574	14	ddi	ddi	NOUN
admet-923	574	15	by	by	ADP
admet-923	574	16	pbpk	pbpk	NOUN
admet-923	574	17	modelling	model	VERB
admet-923	574	18	[	[	X
admet-923	574	19	12,160,161	12,160,161	NUM
admet-923	574	20	]	]	PUNCT
admet-923	574	21	.	.	PUNCT
admet-923	575	1	because	because	SCONJ
admet-923	575	2	it	it	PRON
admet-923	575	3	is	be	AUX
admet-923	575	4	practically	practically	ADV
admet-923	575	5	impossible	impossible	ADJ
admet-923	575	6	to	to	PART
admet-923	575	7	clinically	clinically	ADV
admet-923	575	8	evaluate	evaluate	VERB
admet-923	575	9	all	all	DET
admet-923	575	10	ddi	ddi	ADJ
admet-923	575	11	combinations	combination	NOUN
admet-923	575	12	,	,	PUNCT
admet-923	575	13	ddi	ddi	NOUN
admet-923	575	14	prediction	prediction	NOUN
admet-923	575	15	by	by	ADP
admet-923	575	16	a	a	DET
admet-923	575	17	local	local	ADJ
admet-923	575	18	middle	middle	ADJ
admet-923	575	19	-	-	PUNCT
admet-923	575	20	out	out	ADP
admet-923	575	21	approach	approach	NOUN
admet-923	575	22	would	would	AUX
admet-923	575	23	be	be	AUX
admet-923	575	24	of	of	ADP
admet-923	575	25	great	great	ADJ
admet-923	575	26	value	value	NOUN
admet-923	575	27	.	.	PUNCT
admet-923	576	1	in	in	ADP
admet-923	576	2	the	the	DET
admet-923	576	3	local	local	ADJ
admet-923	576	4	middle	middle	ADJ
admet-923	576	5	-	-	PUNCT
admet-923	576	6	out	out	ADP
admet-923	576	7	approach	approach	NOUN
admet-923	576	8	for	for	ADP
admet-923	576	9	ddi	ddi	PROPN
admet-923	576	10	,	,	PUNCT
admet-923	576	11	to	to	PART
admet-923	576	12	identify	identify	VERB
admet-923	576	13	the	the	DET
admet-923	576	14	fraction	fraction	NOUN
admet-923	576	15	of	of	ADP
admet-923	576	16	metabolic	metabolic	NOUN
admet-923	576	17	clearance	clearance	NOUN
admet-923	576	18	(	(	PUNCT
admet-923	576	19	fm	fm	NOUN
admet-923	576	20	)	)	PUNCT
admet-923	576	21	(	(	PUNCT
admet-923	576	22	e.g.	e.g.	ADV
admet-923	576	23	,	,	PUNCT
admet-923	576	24	a	a	DET
admet-923	576	25	cyp	cyp	ADJ
admet-923	576	26	isozyme	isozyme	NOUN
admet-923	576	27	)	)	PUNCT
admet-923	576	28	,	,	PUNCT
admet-923	576	29	a	a	DET
admet-923	576	30	specific	specific	ADJ
admet-923	576	31	inhibitor	inhibitor	NOUN
admet-923	576	32	has	have	AUX
admet-923	576	33	been	be	AUX
admet-923	576	34	used	use	VERB
admet-923	576	35	in	in	ADP
admet-923	576	36	a	a	DET
admet-923	576	37	clinical	clinical	ADJ
admet-923	576	38	pk	pk	NOUN
admet-923	576	39	study	study	NOUN
admet-923	576	40	(	(	PUNCT
admet-923	576	41	section	section	NOUN
admet-923	576	42	3.8	3.8	NUM
admet-923	576	43	(	(	PUNCT
admet-923	576	44	i	i	NOUN
admet-923	576	45	)	)	PUNCT
admet-923	576	46	)	)	PUNCT
admet-923	576	47	.	.	PUNCT
admet-923	577	1	in	in	ADP
admet-923	577	2	the	the	DET
admet-923	577	3	following	following	NOUN
admet-923	577	4	,	,	PUNCT
admet-923	577	5	the	the	DET
admet-923	577	6	concept	concept	NOUN
admet-923	577	7	of	of	ADP
admet-923	577	8	ddi	ddi	PROPN
admet-923	577	9	prediction	prediction	NOUN
admet-923	577	10	by	by	ADP
admet-923	577	11	the	the	DET
admet-923	577	12	local	local	ADJ
admet-923	577	13	middle	middle	ADJ
admet-923	577	14	-	-	PUNCT
admet-923	577	15	out	out	ADP
admet-923	577	16	approach	approach	NOUN
admet-923	577	17	is	be	AUX
admet-923	577	18	briefly	briefly	ADV
admet-923	577	19	explained	explain	VERB
admet-923	577	20	(	(	PUNCT
admet-923	577	21	see	see	VERB
admet-923	577	22	[	[	X
admet-923	577	23	12,160,161	12,160,161	NUM
admet-923	577	24	]	]	PUNCT
admet-923	577	25	for	for	ADP
admet-923	577	26	details	detail	NOUN
admet-923	577	27	)	)	PUNCT
admet-923	577	28	.	.	PUNCT
admet-923	578	1	in	in	ADP
admet-923	578	2	the	the	DET
admet-923	578	3	case	case	NOUN
admet-923	578	4	of	of	ADP
admet-923	578	5	i.v	i.v	PROPN
admet-923	578	6	.	.	PUNCT
admet-923	579	1	dosing	dose	VERB
admet-923	579	2	(	(	PUNCT
admet-923	579	3	or	or	CCONJ
admet-923	579	4	f	f	X
admet-923	579	5	=	=	SYM
admet-923	579	6	1	1	NUM
admet-923	579	7	for	for	ADP
admet-923	579	8	oral	oral	ADJ
admet-923	579	9	dosing	dosing	NOUN
admet-923	579	10	)	)	PUNCT
admet-923	579	11	,	,	PUNCT
admet-923	579	12	cl	cl	NOUN
admet-923	579	13	and	and	CCONJ
admet-923	579	14	auc	auc	VERB
admet-923	579	15	in	in	ADP
admet-923	579	16	the	the	DET
admet-923	579	17	absence	absence	NOUN
admet-923	579	18	of	of	ADP
admet-923	579	19	an	an	DET
admet-923	579	20	inhibitor	inhibitor	NOUN
admet-923	579	21	can	can	AUX
admet-923	579	22	be	be	AUX
admet-923	579	23	expressed	express	VERB
admet-923	579	24	as	as	ADP
admet-923	579	25	:	:	PUNCT
admet-923	579	26			PROPN
admet-923	579	27	ma	ma	PROPN
admet-923	579	28	mb	mb	PROPN
admet-923	579	29	ma	ma	PROPN
admet-923	579	30	mb	mb	PROPN
admet-923	579	31	,	,	PUNCT
admet-923	579	32	1cl	1cl	ADJ
admet-923	579	33	cl	cl	NOUN
admet-923	579	34	f	f	NOUN
admet-923	579	35	f	f	PROPN
admet-923	579	36	f	f	PROPN
admet-923	579	37	f	f	PROPN
admet-923	579	38			ADV
admet-923	579	39			PUNCT
admet-923	580	1			PROPN
admet-923	580	2			NOUN
admet-923	580	3	ma	ma	PROPN
admet-923	580	4	mb	mb	ADP
admet-923	580	5	auc	auc	X
admet-923	580	6	dose	dose	NOUN
admet-923	580	7	cl	cl	NOUN
admet-923	580	8	f	f	PROPN
admet-923	581	1	f	f	PROPN
admet-923	581	2			PROPN
admet-923	581	3			PROPN
admet-923	581	4	where	where	SCONJ
admet-923	581	5	fma	fma	NOUN
admet-923	581	6	and	and	CCONJ
admet-923	581	7	fmb	fmb	PROPN
admet-923	581	8	are	be	AUX
admet-923	581	9	the	the	DET
admet-923	581	10	fractions	fraction	NOUN
admet-923	581	11	of	of	ADP
admet-923	581	12	metabolic	metabolic	NOUN
admet-923	581	13	clearance	clearance	NOUN
admet-923	581	14	pathways	pathway	NOUN
admet-923	581	15	(	(	PUNCT
admet-923	581	16	a	a	PRON
admet-923	581	17	and	and	CCONJ
admet-923	581	18	b	b	NOUN
admet-923	581	19	,	,	PUNCT
admet-923	581	20	respectively	respectively	ADV
admet-923	581	21	)	)	PUNCT
admet-923	581	22	.	.	PUNCT
admet-923	582	1	the	the	DET
admet-923	582	2	fmb	fmb	PROPN
admet-923	582	3	can	can	AUX
admet-923	582	4	be	be	AUX
admet-923	582	5	calculated	calculate	VERB
admet-923	582	6	from	from	ADP
admet-923	582	7	the	the	DET
admet-923	582	8	auc	auc	NOUN
admet-923	582	9	ratio	ratio	NOUN
admet-923	582	10	in	in	ADP
admet-923	582	11	the	the	DET
admet-923	582	12	absence	absence	NOUN
admet-923	582	13	(	(	PUNCT
admet-923	582	14	aucno	aucno	NOUN
admet-923	582	15	-	-	PUNCT
admet-923	582	16	inhibition	inhibition	NOUN
admet-923	582	17	)	)	PUNCT
admet-923	582	18	and	and	CCONJ
admet-923	582	19	presence	presence	NOUN
admet-923	582	20	(	(	PUNCT
admet-923	582	21	aucinhibition	aucinhibition	NOUN
admet-923	582	22	,	,	PUNCT
admet-923	582	23	fmb	fmb	PROPN
admet-923	582	24	=	=	NOUN
admet-923	582	25	0	0	NUM
admet-923	582	26	)	)	PUNCT
admet-923	582	27	of	of	ADP
admet-923	582	28	a	a	DET
admet-923	582	29	specific	specific	ADJ
admet-923	582	30	strong	strong	ADJ
admet-923	582	31	inhibitor	inhibitor	NOUN
admet-923	582	32	as	as	ADP
admet-923	582	33	:	:	PUNCT
admet-923	582	34	no	no	DET
admet-923	582	35	-	-	PUNCT
admet-923	582	36	inhibition	inhibition	NOUN
admet-923	582	37	mb	mb	NOUN
admet-923	582	38	inhibition	inhibition	NOUN
admet-923	582	39	auc	auc	NOUN
admet-923	582	40	1	1	NUM
admet-923	582	41	auc	auc	NOUN
admet-923	582	42	f	f	PROPN
admet-923	583	1			NOUN
admet-923	583	2			VERB
admet-923	583	3	the	the	DET
admet-923	583	4	inhibitor	inhibitor	NOUN
admet-923	583	5	should	should	AUX
admet-923	583	6	specifically	specifically	ADV
admet-923	583	7	inhibit	inhibit	VERB
admet-923	583	8	only	only	ADV
admet-923	583	9	pathway	pathway	NOUN
admet-923	583	10	b	b	PROPN
admet-923	583	11	and	and	CCONJ
admet-923	583	12	there	there	PRON
admet-923	583	13	is	be	VERB
admet-923	583	14	no	no	DET
admet-923	583	15	other	other	ADJ
admet-923	583	16	underlying	underlying	ADJ
admet-923	583	17	clearance	clearance	NOUN
admet-923	583	18	mechanism	mechanism	NOUN
admet-923	583	19	(	(	PUNCT
admet-923	583	20	e.g.	e.g.	ADV
admet-923	583	21	renal	renal	ADJ
admet-923	583	22	clearance	clearance	NOUN
admet-923	583	23	)	)	PUNCT
admet-923	583	24	or	or	CCONJ
admet-923	583	25	uptake	uptake	ADJ
admet-923	583	26	/	/	SYM
admet-923	583	27	efflux	efflux	NOUN
admet-923	583	28	transporter	transporter	NOUN
admet-923	583	29	in	in	ADP
admet-923	583	30	interplay	interplay	NOUN
admet-923	583	31	which	which	PRON
admet-923	583	32	can	can	AUX
admet-923	583	33	be	be	AUX
admet-923	583	34	influenced	influence	VERB
admet-923	583	35	by	by	ADP
admet-923	583	36	the	the	DET
admet-923	583	37	inhibitor	inhibitor	NOUN
admet-923	583	38	.	.	PUNCT
admet-923	584	1	in	in	ADP
admet-923	584	2	this	this	DET
admet-923	584	3	case	case	NOUN
admet-923	584	4	,	,	PUNCT
admet-923	584	5	the	the	DET
admet-923	584	6	fmb	fmb	PROPN
admet-923	584	7	value	value	NOUN
admet-923	584	8	is	be	AUX
admet-923	584	9	identifiable	identifiable	ADJ
admet-923	584	10	from	from	ADP
admet-923	584	11	the	the	DET
admet-923	584	12	auc	auc	NOUN
admet-923	584	13	ratio	ratio	NOUN
admet-923	584	14	.	.	PUNCT
admet-923	585	1	this	this	DET
admet-923	585	2	equation	equation	NOUN
admet-923	585	3	also	also	ADV
admet-923	585	4	suggests	suggest	VERB
admet-923	585	5	that	that	SCONJ
admet-923	585	6	the	the	DET
admet-923	585	7	auc	auc	NOUN
admet-923	585	8	ratio	ratio	NOUN
admet-923	585	9	is	be	AUX
admet-923	585	10	predictable	predictable	ADJ
admet-923	585	11	without	without	ADP
admet-923	585	12	using	use	VERB
admet-923	585	13	any	any	DET
admet-923	585	14	complex	complex	ADJ
admet-923	585	15	pbpk	pbpk	NOUN
admet-923	585	16	modelling	modelling	NOUN
admet-923	585	17	.	.	PUNCT
admet-923	586	1	a	a	DET
admet-923	586	2	simple	simple	ADJ
admet-923	586	3	prediction	prediction	NOUN
admet-923	586	4	scheme	scheme	NOUN
admet-923	586	5	for	for	ADP
admet-923	586	6	metabolic	metabolic	NOUN
admet-923	586	7	ddi	ddi	NOUN
admet-923	586	8	(	(	PUNCT
admet-923	586	9	auc	auc	NOUN
admet-923	586	10	ratio	ratio	NOUN
admet-923	586	11	)	)	PUNCT
admet-923	586	12	has	have	AUX
admet-923	586	13	been	be	AUX
admet-923	586	14	proposed	propose	VERB
admet-923	586	15	and	and	CCONJ
admet-923	586	16	thoroughly	thoroughly	ADV
admet-923	586	17	validated	validated	ADJ
admet-923	586	18	using	use	VERB
admet-923	586	19	a	a	DET
admet-923	586	20	large	large	ADJ
admet-923	586	21	number	number	NOUN
admet-923	586	22	of	of	ADP
admet-923	586	23	clinical	clinical	ADJ
admet-923	586	24	ddi	ddi	PROPN
admet-923	586	25	data	datum	NOUN
admet-923	586	26	(	(	PUNCT
admet-923	586	27	section	section	NOUN
admet-923	586	28	2.8	2.8	NUM
admet-923	586	29	)	)	PUNCT
admet-923	587	1	[	[	X
admet-923	587	2	67,162–164	67,162–164	NUM
admet-923	587	3	]	]	PUNCT
admet-923	587	4	.	.	PUNCT
admet-923	588	1	however	however	ADV
admet-923	588	2	,	,	PUNCT
admet-923	588	3	a	a	DET
admet-923	588	4	similar	similar	ADJ
admet-923	588	5	approach	approach	NOUN
admet-923	588	6	can	can	AUX
admet-923	588	7	not	not	PART
admet-923	588	8	be	be	AUX
admet-923	588	9	simply	simply	ADV
admet-923	588	10	applied	apply	VERB
admet-923	588	11	to	to	ADP
admet-923	588	12	the	the	DET
admet-923	588	13	food	food	NOUN
admet-923	588	14	effect	effect	NOUN
admet-923	588	15	prediction	prediction	NOUN
admet-923	588	16	,	,	PUNCT
admet-923	588	17	because	because	SCONJ
admet-923	588	18	a	a	DET
admet-923	588	19	food	food	NOUN
admet-923	588	20	intake	intake	NOUN
admet-923	588	21	simultaneously	simultaneously	ADV
admet-923	588	22	affects	affect	VERB
admet-923	588	23	various	various	ADJ
admet-923	588	24	processes	process	NOUN
admet-923	588	25	of	of	ADP
admet-923	588	26	oral	oral	ADJ
admet-923	588	27	drug	drug	NOUN
admet-923	588	28	absorption	absorption	NOUN
admet-923	588	29	(	(	PUNCT
admet-923	588	30	section	section	NOUN
admet-923	588	31	2.7	2.7	NUM
admet-923	588	32	)	)	PUNCT
admet-923	589	1	[	[	X
admet-923	589	2	165	165	NUM
admet-923	589	3	]	]	PUNCT
admet-923	589	4	.	.	PUNCT
admet-923	590	1	3.14	3.14	NUM
admet-923	590	2	.	.	PUNCT
admet-923	591	1	what	what	PRON
admet-923	591	2	is	be	AUX
admet-923	591	3	the	the	DET
admet-923	591	4	difference	difference	NOUN
admet-923	591	5	between	between	ADP
admet-923	591	6	pbpk	pbpk	NOUN
admet-923	591	7	and	and	CCONJ
admet-923	591	8	compartmental	compartmental	ADJ
admet-923	591	9	pk	pk	NOUN
admet-923	591	10	models	model	NOUN
admet-923	591	11	?	?	PUNCT
admet-923	592	1	https://doi.org/10.5599/admet.923	https://doi.org/10.5599/admet.923	X
admet-923	592	2	kiyohiko	kiyohiko	PROPN
admet-923	592	3	sugano	sugano	PROPN
admet-923	592	4	admet	admet	PROPN
admet-923	592	5	&	&	CCONJ
admet-923	592	6	dmpk	dmpk	PROPN
admet-923	592	7	9(2	9(2	NUM
admet-923	592	8	)	)	PUNCT
admet-923	592	9	(	(	PUNCT
admet-923	592	10	2021	2021	NUM
admet-923	592	11	)	)	PUNCT
admet-923	592	12	75	75	NUM
admet-923	592	13	-	-	SYM
admet-923	592	14	109	109	NUM
admet-923	592	15	96	96	NUM
admet-923	592	16	in	in	ADP
admet-923	592	17	pharmacokinetics	pharmacokinetic	NOUN
admet-923	593	1	,	,	PUNCT
admet-923	593	2	the	the	DET
admet-923	593	3	compartmental	compartmental	ADJ
admet-923	593	4	pk	pk	NOUN
admet-923	593	5	model	model	NOUN
admet-923	593	6	is	be	AUX
admet-923	593	7	widely	widely	ADV
admet-923	593	8	used	use	VERB
admet-923	593	9	.	.	PUNCT
admet-923	594	1	although	although	SCONJ
admet-923	594	2	both	both	PRON
admet-923	594	3	compartmental	compartmental	ADJ
admet-923	594	4	pk	pk	NOUN
admet-923	594	5	models	model	NOUN
admet-923	594	6	and	and	CCONJ
admet-923	594	7	pbpk	pbpk	NOUN
admet-923	594	8	models	model	NOUN
admet-923	594	9	belong	belong	VERB
admet-923	594	10	to	to	ADP
admet-923	594	11	mathematical	mathematical	ADJ
admet-923	594	12	models	model	NOUN
admet-923	594	13	,	,	PUNCT
admet-923	594	14	their	their	PRON
admet-923	594	15	applications	application	NOUN
admet-923	594	16	are	be	AUX
admet-923	594	17	different	different	ADJ
admet-923	594	18	.	.	PUNCT
admet-923	595	1	in	in	ADP
admet-923	595	2	compartmental	compartmental	ADJ
admet-923	595	3	pk	pk	NOUN
admet-923	595	4	models	model	NOUN
admet-923	595	5	,	,	PUNCT
admet-923	595	6	all	all	DET
admet-923	595	7	parameters	parameter	NOUN
admet-923	595	8	are	be	AUX
admet-923	595	9	calculated	calculate	VERB
admet-923	595	10	from	from	ADP
admet-923	595	11	clinical	clinical	ADJ
admet-923	595	12	pk	pk	NOUN
admet-923	595	13	data	datum	NOUN
admet-923	595	14	(	(	PUNCT
admet-923	595	15	“	"	PUNCT
admet-923	595	16	top	top	ADJ
admet-923	595	17	-	-	PUNCT
admet-923	595	18	down	down	ADJ
admet-923	595	19	”	"	PUNCT
admet-923	595	20	approach	approach	NOUN
admet-923	595	21	)	)	PUNCT
admet-923	595	22	(	(	PUNCT
admet-923	595	23	section	section	NOUN
admet-923	595	24	3.1	3.1	NUM
admet-923	595	25	)	)	PUNCT
admet-923	595	26	.	.	PUNCT
admet-923	596	1	because	because	SCONJ
admet-923	596	2	the	the	DET
admet-923	596	3	compartmental	compartmental	ADJ
admet-923	596	4	pk	pk	NOUN
admet-923	596	5	model	model	NOUN
admet-923	596	6	is	be	AUX
admet-923	596	7	empirical	empirical	ADJ
admet-923	596	8	,	,	PUNCT
admet-923	596	9	it	it	PRON
admet-923	596	10	is	be	AUX
admet-923	596	11	used	use	VERB
admet-923	596	12	following	follow	VERB
admet-923	596	13	the	the	DET
admet-923	596	14	good	good	ADJ
admet-923	596	15	practice	practice	NOUN
admet-923	596	16	of	of	ADP
admet-923	596	17	empirical	empirical	ADJ
admet-923	596	18	modelling	modelling	NOUN
admet-923	596	19	(	(	PUNCT
admet-923	596	20	section	section	NOUN
admet-923	596	21	3.1	3.1	NUM
admet-923	596	22	)	)	PUNCT
admet-923	596	23	.	.	PUNCT
admet-923	597	1	to	to	PART
admet-923	597	2	avoid	avoid	VERB
admet-923	597	3	overfitting	overfitte	VERB
admet-923	597	4	(	(	PUNCT
admet-923	597	5	section	section	NOUN
admet-923	597	6	2.2	2.2	NUM
admet-923	597	7	,	,	PUNCT
admet-923	597	8	figure	figure	NOUN
admet-923	597	9	3	3	NUM
admet-923	597	10	)	)	PUNCT
admet-923	597	11	,	,	PUNCT
admet-923	597	12	the	the	DET
admet-923	597	13	akaike	akaike	ADJ
admet-923	597	14	information	information	NOUN
admet-923	597	15	criterion	criterion	NOUN
admet-923	597	16	has	have	AUX
admet-923	597	17	been	be	AUX
admet-923	597	18	used	use	VERB
admet-923	597	19	to	to	PART
admet-923	597	20	select	select	VERB
admet-923	597	21	the	the	DET
admet-923	597	22	number	number	NOUN
admet-923	597	23	of	of	ADP
admet-923	597	24	compartments	compartment	NOUN
admet-923	597	25	appropriately	appropriately	ADV
admet-923	597	26	[	[	X
admet-923	597	27	69	69	NUM
admet-923	597	28	]	]	PUNCT
admet-923	597	29	.	.	PUNCT
admet-923	598	1	for	for	ADP
admet-923	598	2	an	an	DET
admet-923	598	3	i.v	i.v	PROPN
admet-923	598	4	.	.	PUNCT
admet-923	598	5	pk	pk	PROPN
admet-923	598	6	model	model	NOUN
admet-923	598	7	,	,	PUNCT
admet-923	598	8	the	the	DET
admet-923	598	9	number	number	NOUN
admet-923	598	10	of	of	ADP
admet-923	598	11	compartments	compartment	NOUN
admet-923	598	12	is	be	AUX
admet-923	598	13	set	set	VERB
admet-923	598	14	to	to	PART
admet-923	598	15	be	be	AUX
admet-923	598	16	one	one	NUM
admet-923	598	17	or	or	CCONJ
admet-923	598	18	two	two	NUM
admet-923	598	19	in	in	ADP
admet-923	598	20	most	most	ADJ
admet-923	598	21	cases	case	NOUN
admet-923	598	22	(	(	PUNCT
admet-923	598	23	2	2	NUM
admet-923	598	24	and	and	CCONJ
admet-923	598	25	4	4	NUM
admet-923	598	26	parameters	parameter	NOUN
admet-923	598	27	,	,	PUNCT
admet-923	598	28	respectively	respectively	ADV
admet-923	598	29	)	)	PUNCT
admet-923	598	30	.	.	PUNCT
admet-923	599	1	for	for	ADP
admet-923	599	2	an	an	DET
admet-923	599	3	oral	oral	ADJ
admet-923	599	4	pk	pk	NOUN
admet-923	599	5	model	model	NOUN
admet-923	599	6	,	,	PUNCT
admet-923	599	7	only	only	ADV
admet-923	599	8	three	three	NUM
admet-923	599	9	parameters	parameter	NOUN
admet-923	599	10	,	,	PUNCT
admet-923	599	11	that	that	ADV
admet-923	599	12	is	is	ADV
admet-923	599	13	,	,	PUNCT
admet-923	599	14	kel	kel	PROPN
admet-923	599	15	,	,	PUNCT
admet-923	599	16	ka	ka	PROPN
admet-923	599	17	,	,	PUNCT
admet-923	599	18	and	and	CCONJ
admet-923	599	19	vd	vd	NOUN
admet-923	599	20	/f	/f	X
admet-923	599	21	are	be	AUX
admet-923	599	22	used	use	VERB
admet-923	599	23	in	in	ADP
admet-923	599	24	most	most	ADJ
admet-923	599	25	cases	case	NOUN
admet-923	599	26	(	(	PUNCT
admet-923	599	27	figure	figure	NOUN
admet-923	599	28	7	7	NUM
admet-923	599	29	)	)	PUNCT
admet-923	599	30	.	.	PUNCT
admet-923	600	1	figure	figure	VERB
admet-923	600	2	7	7	NUM
admet-923	600	3	.	.	PUNCT
admet-923	601	1	an	an	DET
admet-923	601	2	oral	oral	ADJ
admet-923	601	3	one	one	NUM
admet-923	601	4	-	-	PUNCT
admet-923	601	5	compartment	compartment	NOUN
admet-923	601	6	model	model	NOUN
admet-923	601	7	with	with	ADP
admet-923	601	8	an	an	DET
admet-923	601	9	finite	finite	ADJ
admet-923	601	10	absorption	absorption	NOUN
admet-923	601	11	time	time	NOUN
admet-923	601	12	of	of	ADP
admet-923	601	13	t	t	NOUN
admet-923	601	14	=	=	SYM
admet-923	601	15	3.5	3.5	NUM
admet-923	601	16	h	h	NOUN
admet-923	602	1	[	[	X
admet-923	602	2	86,166	86,166	NUM
admet-923	602	3	]	]	PUNCT
admet-923	602	4	.	.	PUNCT
admet-923	603	1	in	in	ADP
admet-923	603	2	many	many	ADJ
admet-923	603	3	cases	case	NOUN
admet-923	603	4	,	,	PUNCT
admet-923	603	5	an	an	DET
admet-923	603	6	oral	oral	ADJ
admet-923	603	7	cp	cp	NOUN
admet-923	603	8	time	time	NOUN
admet-923	603	9	profile	profile	NOUN
admet-923	603	10	can	can	AUX
admet-923	603	11	be	be	AUX
admet-923	603	12	summarized	summarize	VERB
admet-923	603	13	into	into	ADP
admet-923	603	14	three	three	NUM
admet-923	603	15	parameters	parameter	NOUN
admet-923	603	16	,	,	PUNCT
admet-923	603	17	ka	ka	PROPN
admet-923	603	18	,	,	PUNCT
admet-923	603	19	the	the	DET
admet-923	603	20	elimination	elimination	NOUN
admet-923	603	21	rate	rate	NOUN
admet-923	603	22	constant	constant	ADJ
admet-923	603	23	(	(	PUNCT
admet-923	603	24	kel	kel	NOUN
admet-923	603	25	)	)	PUNCT
admet-923	603	26	,	,	PUNCT
admet-923	603	27	and	and	CCONJ
admet-923	603	28	the	the	DET
admet-923	603	29	lumped	lump	VERB
admet-923	603	30	values	value	NOUN
admet-923	603	31	of	of	ADP
admet-923	603	32	the	the	DET
admet-923	603	33	volume	volume	NOUN
admet-923	603	34	of	of	ADP
admet-923	603	35	distribution	distribution	NOUN
admet-923	603	36	(	(	PUNCT
admet-923	603	37	vd	vd	NOUN
admet-923	603	38	)	)	PUNCT
admet-923	603	39	,	,	PUNCT
admet-923	603	40	fg	fg	PROPN
admet-923	603	41	,	,	PUNCT
admet-923	603	42	and	and	CCONJ
admet-923	603	43	fh	fh	PROPN
admet-923	603	44	(	(	PUNCT
admet-923	603	45	vd	vd	NOUN
admet-923	603	46	/fgfh	/fgfh	PUNCT
admet-923	603	47	)	)	PUNCT
admet-923	603	48	.	.	PUNCT
admet-923	604	1	tmax	tmax	ADV
admet-923	604	2	,	,	PUNCT
admet-923	604	3	cmax	cmax	NOUN
admet-923	604	4	,	,	PUNCT
admet-923	604	5	and	and	CCONJ
admet-923	604	6	auc	auc	NOUN
admet-923	604	7	are	be	AUX
admet-923	604	8	all	all	PRON
admet-923	604	9	described	describe	VERB
admet-923	604	10	by	by	ADP
admet-923	604	11	using	use	VERB
admet-923	604	12	only	only	ADV
admet-923	604	13	one	one	NUM
admet-923	604	14	absorption	absorption	NOUN
admet-923	604	15	parameter	parameter	NOUN
admet-923	604	16	(	(	PUNCT
admet-923	604	17	ka	ka	PROPN
admet-923	604	18	)	)	PUNCT
admet-923	604	19	that	that	PRON
admet-923	604	20	represents	represent	VERB
admet-923	604	21	the	the	DET
admet-923	604	22	oral	oral	ADJ
admet-923	604	23	absorption	absorption	NOUN
admet-923	604	24	of	of	ADP
admet-923	604	25	a	a	DET
admet-923	604	26	drug	drug	NOUN
admet-923	604	27	.	.	PUNCT
admet-923	605	1	therefore	therefore	ADV
admet-923	605	2	,	,	PUNCT
admet-923	605	3	the	the	DET
admet-923	605	4	oral	oral	ADJ
admet-923	605	5	absorption	absorption	NOUN
admet-923	605	6	of	of	ADP
admet-923	605	7	a	a	DET
admet-923	605	8	drug	drug	NOUN
admet-923	605	9	can	can	AUX
admet-923	605	10	be	be	AUX
admet-923	605	11	well	well	ADV
admet-923	605	12	described	describe	VERB
admet-923	605	13	by	by	ADP
admet-923	605	14	fitting	fit	VERB
admet-923	605	15	one	one	NUM
admet-923	605	16	of	of	ADP
admet-923	605	17	many	many	ADJ
admet-923	605	18	conjugated	conjugated	ADJ
admet-923	605	19	parameters	parameter	NOUN
admet-923	605	20	in	in	ADP
admet-923	605	21	a	a	DET
admet-923	605	22	complex	complex	ADJ
admet-923	605	23	oa	oa	ADP
admet-923	605	24	pbpk	pbpk	NOUN
admet-923	605	25	model	model	NOUN
admet-923	605	26	(	(	PUNCT
admet-923	605	27	the	the	DET
admet-923	605	28	degree	degree	NOUN
admet-923	605	29	of	of	ADP
admet-923	605	30	freedom	freedom	NOUN
admet-923	605	31	is	be	AUX
admet-923	605	32	zero	zero	NUM
admet-923	605	33	)	)	PUNCT
admet-923	605	34	.	.	PUNCT
admet-923	606	1	from	from	ADP
admet-923	606	2	the	the	DET
admet-923	606	3	cp	cp	NUM
admet-923	606	4	-time	-time	PROPN
admet-923	606	5	profile	profile	NOUN
admet-923	606	6	after	after	ADP
admet-923	606	7	oral	oral	ADJ
admet-923	606	8	administration	administration	NOUN
admet-923	606	9	,	,	PUNCT
admet-923	606	10	only	only	ADV
admet-923	606	11	the	the	DET
admet-923	606	12	composite	composite	ADJ
admet-923	606	13	parameter	parameter	NOUN
admet-923	606	14	of	of	ADP
admet-923	606	15	vd	vd	NOUN
admet-923	606	16	/	/	SYM
admet-923	606	17	fgfh	fgfh	PROPN
admet-923	606	18	is	be	AUX
admet-923	606	19	identifiable	identifiable	ADJ
admet-923	606	20	.	.	PUNCT
admet-923	607	1	an	an	DET
admet-923	607	2	i.v	i.v	PROPN
admet-923	607	3	.	.	PUNCT
admet-923	607	4	data	data	PROPN
admet-923	607	5	is	be	AUX
admet-923	607	6	required	require	VERB
admet-923	607	7	to	to	PART
admet-923	607	8	fix	fix	VERB
admet-923	607	9	vd	vd	NOUN
admet-923	607	10	(	(	PUNCT
admet-923	607	11	and	and	CCONJ
admet-923	607	12	cl	cl	NOUN
admet-923	607	13	)	)	PUNCT
admet-923	608	1	[	[	X
admet-923	608	2	33	33	NUM
admet-923	608	3	]	]	PUNCT
admet-923	608	4	.	.	PUNCT
admet-923	609	1	in	in	ADP
admet-923	609	2	contrast	contrast	NOUN
admet-923	609	3	,	,	PUNCT
admet-923	609	4	a	a	DET
admet-923	609	5	pbpk	pbpk	ADJ
admet-923	609	6	model	model	NOUN
admet-923	609	7	consists	consist	VERB
admet-923	609	8	of	of	ADP
admet-923	609	9	dozens	dozen	NOUN
admet-923	609	10	to	to	ADP
admet-923	609	11	hundreds	hundred	NOUN
admet-923	609	12	of	of	ADP
admet-923	609	13	parameters	parameter	NOUN
admet-923	609	14	(	(	PUNCT
admet-923	609	15	section	section	NOUN
admet-923	609	16	2.1	2.1	NUM
admet-923	609	17	)	)	PUNCT
admet-923	610	1	[	[	X
admet-923	610	2	37	37	NUM
admet-923	610	3	]	]	PUNCT
admet-923	610	4	.	.	PUNCT
admet-923	611	1	all	all	DET
admet-923	611	2	these	these	DET
admet-923	611	3	parameters	parameter	NOUN
admet-923	611	4	can	can	AUX
admet-923	611	5	not	not	PART
admet-923	611	6	be	be	AUX
admet-923	611	7	identified	identify	VERB
admet-923	611	8	from	from	ADP
admet-923	611	9	the	the	DET
admet-923	611	10	cp	cp	NUM
admet-923	611	11	-time	-time	PROPN
admet-923	611	12	profile	profile	NOUN
admet-923	611	13	alone	alone	ADV
admet-923	611	14	(	(	PUNCT
admet-923	611	15	section	section	NOUN
admet-923	611	16	3.8	3.8	NUM
admet-923	611	17	)	)	PUNCT
admet-923	611	18	.	.	PUNCT
admet-923	612	1	3.15	3.15	NUM
admet-923	612	2	.	.	PUNCT
admet-923	613	1	global	global	ADJ
admet-923	613	2	middle	middle	ADJ
admet-923	613	3	-	-	PUNCT
admet-923	613	4	out	out	ADP
admet-923	613	5	approach	approach	NOUN
admet-923	613	6	(	(	PUNCT
admet-923	613	7	system	system	NOUN
admet-923	613	8	parameter	parameter	NOUN
admet-923	613	9	estimation	estimation	PROPN
admet-923	613	10	)	)	PUNCT
admet-923	613	11	in	in	ADP
admet-923	613	12	pbpk	pbpk	NOUN
admet-923	613	13	modelling	modelling	NOUN
admet-923	613	14	,	,	PUNCT
admet-923	613	15	it	it	PRON
admet-923	613	16	is	be	AUX
admet-923	613	17	preferable	preferable	ADJ
admet-923	613	18	to	to	PART
admet-923	613	19	use	use	VERB
admet-923	613	20	experimentally	experimentally	ADV
admet-923	613	21	measured	measure	VERB
admet-923	613	22	physiological	physiological	ADJ
admet-923	613	23	parameters	parameter	NOUN
admet-923	613	24	.	.	PUNCT
admet-923	614	1	however	however	ADV
admet-923	614	2	,	,	PUNCT
admet-923	614	3	some	some	PRON
admet-923	614	4	of	of	ADP
admet-923	614	5	the	the	DET
admet-923	614	6	physiological	physiological	ADJ
admet-923	614	7	parameters	parameter	NOUN
admet-923	614	8	are	be	AUX
admet-923	614	9	not	not	PART
admet-923	614	10	available	available	ADJ
admet-923	614	11	.	.	PUNCT
admet-923	615	1	in	in	ADP
admet-923	615	2	such	such	DET
admet-923	615	3	a	a	DET
admet-923	615	4	case	case	NOUN
admet-923	615	5	,	,	PUNCT
admet-923	615	6	a	a	DET
admet-923	615	7	global	global	ADJ
admet-923	615	8	middle	middle	ADJ
admet-923	615	9	-	-	PUNCT
admet-923	615	10	out	out	ADP
admet-923	615	11	approach	approach	NOUN
admet-923	615	12	has	have	AUX
admet-923	615	13	been	be	AUX
admet-923	615	14	used	use	VERB
admet-923	615	15	to	to	PART
admet-923	615	16	back	back	VERB
admet-923	615	17	estimate	estimate	VERB
admet-923	615	18	a	a	DET
admet-923	615	19	physiological	physiological	ADJ
admet-923	615	20	parameter	parameter	NOUN
admet-923	615	21	from	from	ADP
admet-923	615	22	the	the	DET
admet-923	615	23	multiple	multiple	ADJ
admet-923	615	24	pk	pk	NOUN
admet-923	615	25	data	datum	NOUN
admet-923	615	26	of	of	ADP
admet-923	615	27	multiple	multiple	ADJ
admet-923	615	28	drugs	drug	NOUN
admet-923	615	29	(	(	PUNCT
admet-923	615	30	cf	cf	NOUN
admet-923	615	31	.	.	PUNCT
admet-923	616	1	a	a	DET
admet-923	616	2	local	local	ADJ
admet-923	616	3	middle	middle	ADJ
admet-923	616	4	-	-	PUNCT
admet-923	616	5	out	out	ADP
admet-923	616	6	approach	approach	NOUN
admet-923	616	7	is	be	AUX
admet-923	616	8	on	on	ADP
admet-923	616	9	a	a	DET
admet-923	616	10	drug	drug	NOUN
admet-923	616	11	-	-	PUNCT
admet-923	616	12	by	by	ADP
admet-923	616	13	-	-	PUNCT
admet-923	616	14	drug	drug	NOUN
admet-923	616	15	basis	basis	NOUN
admet-923	616	16	)	)	PUNCT
admet-923	616	17	(	(	PUNCT
admet-923	616	18	section	section	NOUN
admet-923	616	19	3.1	3.1	NUM
admet-923	616	20	)	)	PUNCT
admet-923	617	1	[	[	X
admet-923	617	2	83,90,129,145,167	83,90,129,145,167	NUM
admet-923	617	3	]	]	PUNCT
admet-923	617	4	.	.	PUNCT
admet-923	618	1	in	in	ADP
admet-923	618	2	this	this	DET
admet-923	618	3	approach	approach	NOUN
admet-923	618	4	,	,	PUNCT
admet-923	618	5	the	the	DET
admet-923	618	6	following	follow	VERB
admet-923	618	7	three	three	NUM
admet-923	618	8	points	point	NOUN
admet-923	618	9	are	be	AUX
admet-923	618	10	usually	usually	ADV
admet-923	618	11	carefully	carefully	ADV
admet-923	618	12	considered	consider	VERB
admet-923	618	13	to	to	PART
admet-923	618	14	ensure	ensure	VERB
admet-923	618	15	parameter	parameter	NOUN
admet-923	618	16	identifiability	identifiability	NOUN
admet-923	618	17	and	and	CCONJ
admet-923	618	18	avoid	avoid	VERB
admet-923	618	19	overfitting	overfitte	VERB
admet-923	618	20	:	:	PUNCT
admet-923	618	21	(	(	PUNCT
admet-923	618	22	i	i	NOUN
admet-923	618	23	)	)	PUNCT
admet-923	618	24	enough	enough	ADJ
admet-923	618	25	number	number	NOUN
admet-923	618	26	of	of	ADP
admet-923	618	27	data	datum	NOUN
admet-923	618	28	covering	cover	VERB
admet-923	618	29	a	a	DET
admet-923	618	30	wide	wide	ADJ
admet-923	618	31	range	range	NOUN
admet-923	618	32	of	of	ADP
admet-923	618	33	dependent	dependent	ADJ
admet-923	618	34	and	and	CCONJ
admet-923	618	35	independent	independent	ADJ
admet-923	618	36	variables	variable	NOUN
admet-923	618	37	,	,	PUNCT
admet-923	618	38	(	(	PUNCT
admet-923	618	39	ii	ii	NOUN
admet-923	618	40	)	)	PUNCT
admet-923	618	41	in	in	ADP
admet-923	618	42	vivo	vivo	ADJ
admet-923	618	43	pk	pk	NOUN
admet-923	618	44	data	datum	NOUN
admet-923	618	45	that	that	PRON
admet-923	618	46	is	be	AUX
admet-923	618	47	sensitive	sensitive	ADJ
admet-923	618	48	to	to	ADP
admet-923	618	49	the	the	DET
admet-923	618	50	physiological	physiological	ADJ
admet-923	618	51	parameter	parameter	NOUN
admet-923	618	52	(	(	PUNCT
admet-923	618	53	and	and	CCONJ
admet-923	618	54	not	not	PART
admet-923	618	55	sensitive	sensitive	ADJ
admet-923	618	56	to	to	ADP
admet-923	618	57	the	the	DET
admet-923	618	58	other	other	ADJ
admet-923	618	59	parameters	parameter	NOUN
admet-923	618	60	)	)	PUNCT
admet-923	618	61	,	,	PUNCT
admet-923	618	62	(	(	PUNCT
admet-923	618	63	iii	iii	X
admet-923	618	64	)	)	PUNCT
admet-923	618	65	comparison	comparison	NOUN
admet-923	618	66	with	with	ADP
admet-923	618	67	directly	directly	ADV
admet-923	618	68	or	or	CCONJ
admet-923	618	69	indirectly	indirectly	ADV
admet-923	618	70	measured	measure	VERB
admet-923	618	71	values	value	NOUN
admet-923	618	72	.	.	PUNCT
admet-923	619	1	for	for	ADP
admet-923	619	2	example	example	NOUN
admet-923	619	3	,	,	PUNCT
admet-923	619	4	the	the	DET
admet-923	619	5	volume	volume	NOUN
admet-923	619	6	of	of	ADP
admet-923	619	7	the	the	DET
admet-923	619	8	small	small	ADJ
admet-923	619	9	intestinal	intestinal	ADJ
admet-923	619	10	fluid	fluid	NOUN
admet-923	619	11	(	(	PUNCT
admet-923	619	12	vsi	vsi	PROPN
admet-923	619	13	)	)	PUNCT
admet-923	619	14	available	available	ADJ
admet-923	619	15	for	for	ADP
admet-923	619	16	drug	drug	NOUN
admet-923	619	17	dissolution	dissolution	NOUN
admet-923	619	18	has	have	AUX
admet-923	619	19	not	not	PART
admet-923	619	20	been	be	AUX
admet-923	619	21	clear	clear	ADJ
admet-923	619	22	,	,	PUNCT
admet-923	619	23	because	because	SCONJ
admet-923	619	24	only	only	ADV
admet-923	619	25	free	free	ADJ
admet-923	619	26	water	water	NOUN
admet-923	619	27	can	can	AUX
admet-923	619	28	be	be	AUX
admet-923	619	29	directly	directly	ADV
admet-923	619	30	measured	measure	VERB
admet-923	619	31	by	by	ADP
admet-923	619	32	mri	mri	NOUN
admet-923	619	33	[	[	X
admet-923	619	34	28,29	28,29	NUM
admet-923	619	35	]	]	X
admet-923	619	36	.	.	PUNCT
admet-923	620	1	the	the	DET
admet-923	620	2	vsi	vsi	PROPN
admet-923	620	3	value	value	NOUN
admet-923	620	4	available	available	ADJ
admet-923	620	5	for	for	ADP
admet-923	620	6	drug	drug	NOUN
admet-923	620	7	dissolution	dissolution	NOUN
admet-923	620	8	was	be	AUX
admet-923	620	9	back	back	ADV
admet-923	620	10	-	-	PUNCT
admet-923	620	11	calculated	calculate	VERB
admet-923	620	12	from	from	ADP
admet-923	620	13	the	the	DET
admet-923	620	14	clinical	clinical	ADJ
admet-923	620	15	pk	pk	NOUN
admet-923	620	16	data	datum	NOUN
admet-923	620	17	of	of	ADP
admet-923	620	18	several	several	ADJ
admet-923	620	19	low	low	ADJ
admet-923	620	20	solubility	solubility	NOUN
admet-923	620	21	drugs	drug	NOUN
admet-923	620	22	at	at	ADP
admet-923	620	23	various	various	ADJ
admet-923	620	24	dose	dose	NOUN
admet-923	620	25	strengths	strength	NOUN
admet-923	620	26	covering	cover	VERB
admet-923	620	27	do	do	VERB
admet-923	620	28	<	<	X
admet-923	620	29	1	1	NUM
admet-923	620	30	and	and	CCONJ
admet-923	620	31	do	do	VERB
admet-923	620	32	>	>	X
admet-923	620	33	1	1	NUM
admet-923	621	1	[	[	X
admet-923	621	2	83,167	83,167	NUM
admet-923	621	3	]	]	PUNCT
admet-923	621	4	.	.	PUNCT
admet-923	622	1	the	the	DET
admet-923	622	2	estimated	estimate	VERB
admet-923	622	3	vsi	vsi	PROPN
admet-923	622	4	values	value	NOUN
admet-923	622	5	(	(	PUNCT
admet-923	622	6	130	130	NUM
admet-923	622	7	ml	ml	NOUN
admet-923	622	8	[	[	X
admet-923	622	9	83	83	NUM
admet-923	622	10	]	]	PUNCT
admet-923	622	11	and	and	CCONJ
admet-923	622	12	116	116	NUM
admet-923	622	13	ml	ml	NOUN
admet-923	623	1	[	[	X
admet-923	623	2	167	167	NUM
admet-923	623	3	]	]	PUNCT
admet-923	623	4	)	)	PUNCT
admet-923	623	5	admet	admet	PROPN
admet-923	623	6	&	&	CCONJ
admet-923	623	7	dmpk	dmpk	PROPN
admet-923	623	8	9(2	9(2	NUM
admet-923	623	9	)	)	PUNCT
admet-923	623	10	(	(	PUNCT
admet-923	623	11	2021	2021	NUM
admet-923	623	12	)	)	PUNCT
admet-923	623	13	75	75	NUM
admet-923	623	14	-	-	SYM
admet-923	623	15	109	109	NUM
admet-923	623	16	lost	lose	VERB
admet-923	623	17	in	in	ADP
admet-923	623	18	modelling	modelling	NOUN
admet-923	623	19	and	and	CCONJ
admet-923	623	20	simulation	simulation	NOUN
admet-923	623	21	?	?	PUNCT
admet-923	624	1	doi	doi	NOUN
admet-923	624	2	:	:	PUNCT
admet-923	624	3	https:/doi.org/10.5599	https:/doi.org/10.5599	PROPN
admet-923	624	4	/	/	SYM
admet-923	624	5	admet.923	admet.923	PROPN
admet-923	624	6	97	97	NUM
admet-923	624	7	were	be	AUX
admet-923	624	8	about	about	ADV
admet-923	624	9	1.5	1.5	NUM
admet-923	624	10	to	to	PART
admet-923	624	11	2	2	NUM
admet-923	624	12	-	-	NOUN
admet-923	624	13	fold	fold	VERB
admet-923	624	14	larger	large	ADJ
admet-923	624	15	than	than	ADP
admet-923	624	16	the	the	DET
admet-923	624	17	average	average	ADJ
admet-923	624	18	free	free	ADJ
admet-923	624	19	water	water	NOUN
admet-923	624	20	volume	volume	NOUN
admet-923	624	21	directly	directly	ADV
admet-923	624	22	measured	measure	VERB
admet-923	624	23	by	by	ADP
admet-923	624	24	various	various	ADJ
admet-923	624	25	techniques	technique	NOUN
admet-923	624	26	[	[	X
admet-923	624	27	26,28,29	26,28,29	NUM
admet-923	624	28	]	]	PUNCT
admet-923	624	29	.	.	PUNCT
admet-923	625	1	df	df	PROPN
admet-923	625	2	in	in	ADP
admet-923	625	3	eq	eq	ADP
admet-923	625	4	.	.	PROPN
admet-923	625	5	6	6	NUM
admet-923	625	6	was	be	AUX
admet-923	625	7	obtained	obtain	VERB
admet-923	625	8	from	from	ADP
admet-923	625	9	the	the	DET
admet-923	625	10	relationship	relationship	NOUN
admet-923	625	11	between	between	ADP
admet-923	625	12	the	the	DET
admet-923	625	13	clinical	clinical	ADJ
admet-923	625	14	fa	fa	NOUN
admet-923	625	15	and	and	CCONJ
admet-923	625	16	peff	peff	PROPN
admet-923	625	17	values	value	NOUN
admet-923	625	18	of	of	ADP
admet-923	625	19	about	about	ADV
admet-923	625	20	20	20	NUM
admet-923	625	21	high	high	ADJ
admet-923	625	22	solubility	solubility	NOUN
admet-923	625	23	drugs	drug	NOUN
admet-923	625	24	[	[	X
admet-923	625	25	55	55	NUM
admet-923	625	26	]	]	PUNCT
admet-923	625	27	(	(	PUNCT
admet-923	625	28	cf	cf	NOUN
admet-923	625	29	.	.	PUNCT
admet-923	625	30	fa	fa	PUNCT
admet-923	626	1	=	=	SYM
admet-923	626	2	1	1	NUM
admet-923	626	3	–	–	PUNCT
admet-923	626	4	exp	exp	NOUN
admet-923	626	5	(	(	PUNCT
admet-923	626	6	2df	2df	ADJ
admet-923	626	7	/	/	SYM
admet-923	626	8	rsi	rsi	NOUN
admet-923	626	9	x	x	SYM
admet-923	626	10	peff	peff	PROPN
admet-923	626	11	x	x	SYM
admet-923	626	12	tsi	tsi	PROPN
admet-923	626	13	)	)	PUNCT
admet-923	626	14	.	.	PUNCT
admet-923	627	1	conclusion	conclusion	NOUN
admet-923	627	2	:	:	PUNCT
admet-923	627	3	strategy	strategy	NOUN
admet-923	627	4	to	to	PART
admet-923	627	5	improve	improve	VERB
admet-923	627	6	oral	oral	ADJ
admet-923	627	7	absorption	absorption	NOUN
admet-923	627	8	physiologically	physiologically	ADV
admet-923	627	9	-	-	PUNCT
admet-923	627	10	based	base	VERB
admet-923	627	11	pharmacokinetic	pharmacokinetic	ADJ
admet-923	627	12	modelling	model	VERB
admet-923	627	13	multidisciplinary	multidisciplinary	ADJ
admet-923	627	14	collaboration	collaboration	NOUN
admet-923	627	15	a	a	DET
admet-923	627	16	good	good	ADJ
admet-923	627	17	collaboration	collaboration	NOUN
admet-923	627	18	of	of	ADP
admet-923	627	19	pharmacokinetic	pharmacokinetic	ADJ
admet-923	627	20	,	,	PUNCT
admet-923	627	21	physical	physical	ADJ
admet-923	627	22	chemistry	chemistry	NOUN
admet-923	627	23	,	,	PUNCT
admet-923	627	24	formulation	formulation	NOUN
admet-923	627	25	,	,	PUNCT
admet-923	627	26	and	and	CCONJ
admet-923	627	27	physiology	physiology	NOUN
admet-923	627	28	experts	expert	NOUN
admet-923	627	29	is	be	AUX
admet-923	627	30	required	require	VERB
admet-923	627	31	to	to	PART
admet-923	627	32	improve	improve	VERB
admet-923	627	33	oral	oral	ADJ
admet-923	627	34	absorption	absorption	NOUN
admet-923	627	35	(	(	PUNCT
admet-923	627	36	oa	oa	INTJ
admet-923	627	37	)	)	PUNCT
admet-923	627	38	physiologically	physiologically	ADV
admet-923	627	39	-	-	PUNCT
admet-923	627	40	based	base	VERB
admet-923	627	41	pharmacokinetic	pharmacokinetic	ADJ
admet-923	627	42	(	(	PUNCT
admet-923	627	43	pbpk	pbpk	NOUN
admet-923	627	44	)	)	PUNCT
admet-923	627	45	modelling	modelling	NOUN
admet-923	627	46	.	.	PUNCT
admet-923	628	1	there	there	PRON
admet-923	628	2	are	be	VERB
admet-923	628	3	many	many	ADJ
admet-923	628	4	opportunities	opportunity	NOUN
admet-923	628	5	for	for	SCONJ
admet-923	628	6	both	both	DET
admet-923	628	7	experimentalists	experimentalist	NOUN
admet-923	628	8	and	and	CCONJ
admet-923	628	9	modellers	modeller	NOUN
admet-923	628	10	to	to	PART
admet-923	628	11	take	take	VERB
admet-923	628	12	advantage	advantage	NOUN
admet-923	628	13	of	of	ADP
admet-923	628	14	collaborative	collaborative	ADJ
admet-923	628	15	works	work	NOUN
admet-923	628	16	in	in	ADP
admet-923	628	17	this	this	DET
admet-923	628	18	field	field	NOUN
admet-923	628	19	[	[	X
admet-923	628	20	32	32	NUM
admet-923	628	21	]	]	PUNCT
admet-923	628	22	.	.	PUNCT
admet-923	629	1	the	the	DET
admet-923	629	2	critical	critical	ADJ
admet-923	629	3	role	role	NOUN
admet-923	629	4	of	of	ADP
admet-923	629	5	physical	physical	ADJ
admet-923	629	6	chemistry	chemistry	NOUN
admet-923	629	7	in	in	ADP
admet-923	629	8	oa	oa	NOUN
admet-923	629	9	-	-	PUNCT
admet-923	629	10	pbpk	pbpk	ADJ
admet-923	629	11	modelling	model	VERB
admet-923	629	12	the	the	DET
admet-923	629	13	importance	importance	NOUN
admet-923	629	14	of	of	ADP
admet-923	629	15	physical	physical	ADJ
admet-923	629	16	chemistry	chemistry	NOUN
admet-923	629	17	in	in	ADP
admet-923	629	18	pbpk	pbpk	NOUN
admet-923	629	19	modelling	modelling	NOUN
admet-923	629	20	has	have	AUX
admet-923	629	21	often	often	ADV
admet-923	629	22	been	be	AUX
admet-923	629	23	overlooked	overlook	VERB
admet-923	629	24	(	(	PUNCT
admet-923	629	25	section	section	NOUN
admet-923	629	26	2.7	2.7	NUM
admet-923	629	27	)	)	PUNCT
admet-923	629	28	.	.	PUNCT
admet-923	630	1	physical	physical	ADJ
admet-923	630	2	chemistry	chemistry	NOUN
admet-923	630	3	plays	play	VERB
admet-923	630	4	a	a	DET
admet-923	630	5	central	central	ADJ
admet-923	630	6	role	role	NOUN
admet-923	630	7	in	in	ADP
admet-923	630	8	oral	oral	ADJ
admet-923	630	9	drug	drug	NOUN
admet-923	630	10	absorption	absorption	NOUN
admet-923	630	11	[	[	X
admet-923	630	12	86	86	NUM
admet-923	630	13	]	]	PUNCT
admet-923	630	14	.	.	PUNCT
admet-923	631	1	in	in	ADP
admet-923	631	2	addition	addition	NOUN
admet-923	631	3	,	,	PUNCT
admet-923	631	4	physical	physical	ADJ
admet-923	631	5	chemistry	chemistry	NOUN
admet-923	631	6	is	be	AUX
admet-923	631	7	also	also	ADV
admet-923	631	8	important	important	ADJ
admet-923	631	9	for	for	ADP
admet-923	631	10	hepatic	hepatic	ADJ
admet-923	631	11	clearance	clearance	NOUN
admet-923	631	12	,	,	PUNCT
admet-923	631	13	renal	renal	ADJ
admet-923	631	14	clearance	clearance	NOUN
admet-923	631	15	,	,	PUNCT
admet-923	631	16	and	and	CCONJ
admet-923	631	17	tissue	tissue	NOUN
admet-923	631	18	distribution	distribution	NOUN
admet-923	631	19	(	(	PUNCT
admet-923	631	20	including	include	VERB
admet-923	631	21	the	the	DET
admet-923	631	22	brain	brain	NOUN
admet-923	631	23	)	)	PUNCT
admet-923	632	1	[	[	X
admet-923	632	2	85,168–176	85,168–176	X
admet-923	632	3	]	]	X
admet-923	632	4	.	.	PUNCT
admet-923	633	1	a	a	DET
admet-923	633	2	recent	recent	ADJ
admet-923	633	3	survey	survey	NOUN
admet-923	633	4	suggested	suggest	VERB
admet-923	633	5	that	that	SCONJ
admet-923	633	6	a	a	DET
admet-923	633	7	poor	poor	ADJ
admet-923	633	8	understanding	understanding	NOUN
admet-923	633	9	of	of	ADP
admet-923	633	10	physical	physical	ADJ
admet-923	633	11	chemistry	chemistry	NOUN
admet-923	633	12	is	be	AUX
admet-923	633	13	one	one	NUM
admet-923	633	14	of	of	ADP
admet-923	633	15	the	the	DET
admet-923	633	16	reasons	reason	NOUN
admet-923	633	17	for	for	ADP
admet-923	633	18	the	the	DET
admet-923	633	19	prediction	prediction	NOUN
admet-923	633	20	failure	failure	NOUN
admet-923	633	21	of	of	ADP
admet-923	633	22	oa	oa	PROPN
admet-923	633	23	pbpk	pbpk	NOUN
admet-923	633	24	modelling	model	VERB
admet-923	633	25	[	[	X
admet-923	633	26	6	6	NUM
admet-923	633	27	]	]	PUNCT
admet-923	633	28	.	.	PUNCT
admet-923	634	1	a	a	DET
admet-923	634	2	good	good	ADJ
admet-923	634	3	understanding	understanding	NOUN
admet-923	634	4	of	of	ADP
admet-923	634	5	the	the	DET
admet-923	634	6	chemical	chemical	ADJ
admet-923	634	7	equilibrium	equilibrium	NOUN
admet-923	635	1	[	[	X
admet-923	635	2	177	177	NUM
admet-923	635	3	]	]	PUNCT
admet-923	635	4	,	,	PUNCT
admet-923	635	5	nucleation	nucleation	NOUN
admet-923	635	6	theory	theory	NOUN
admet-923	635	7	[	[	X
admet-923	635	8	115,178	115,178	NUM
admet-923	635	9	]	]	PUNCT
admet-923	635	10	,	,	PUNCT
admet-923	635	11	and	and	CCONJ
admet-923	635	12	fluid	fluid	ADJ
admet-923	635	13	dynamics	dynamic	NOUN
admet-923	635	14	(	(	PUNCT
admet-923	635	15	including	include	VERB
admet-923	635	16	mass	mass	NOUN
admet-923	635	17	transport	transport	NOUN
admet-923	635	18	)	)	PUNCT
admet-923	636	1	[	[	X
admet-923	636	2	172,173,179	172,173,179	NUM
admet-923	636	3	]	]	X
admet-923	636	4	is	be	AUX
admet-923	636	5	required	require	VERB
admet-923	636	6	in	in	ADP
admet-923	636	7	oa	oa	ADP
admet-923	636	8	pbpk	pbpk	NOUN
admet-923	636	9	modelling	modelling	NOUN
admet-923	636	10	.	.	PUNCT
admet-923	637	1	fortunately	fortunately	ADV
admet-923	637	2	,	,	PUNCT
admet-923	637	3	physical	physical	ADJ
admet-923	637	4	chemists	chemist	NOUN
admet-923	637	5	are	be	AUX
admet-923	637	6	generally	generally	ADV
admet-923	637	7	well	well	ADV
admet-923	637	8	trained	train	VERB
admet-923	637	9	in	in	ADP
admet-923	637	10	mathematics	mathematic	NOUN
admet-923	637	11	and	and	CCONJ
admet-923	637	12	mechanistic	mechanistic	ADJ
admet-923	637	13	modelling	modelling	NOUN
admet-923	637	14	.	.	PUNCT
admet-923	638	1	they	they	PRON
admet-923	638	2	are	be	AUX
admet-923	638	3	familiar	familiar	ADJ
admet-923	638	4	with	with	ADP
admet-923	638	5	the	the	DET
admet-923	638	6	concept	concept	NOUN
admet-923	638	7	of	of	ADP
admet-923	638	8	parameter	parameter	NOUN
admet-923	638	9	identifiability	identifiability	NOUN
admet-923	638	10	.	.	PUNCT
admet-923	639	1	the	the	DET
admet-923	639	2	critical	critical	ADJ
admet-923	639	3	role	role	NOUN
admet-923	639	4	of	of	ADP
admet-923	639	5	physiological	physiological	ADJ
admet-923	639	6	parameters	parameter	NOUN
admet-923	639	7	in	in	ADP
admet-923	639	8	oa	oa	ADP
admet-923	639	9	pbpk	pbpk	NOUN
admet-923	639	10	modelling	model	VERB
admet-923	639	11	similarly	similarly	ADV
admet-923	639	12	,	,	PUNCT
admet-923	639	13	an	an	DET
admet-923	639	14	in	in	ADP
admet-923	639	15	-	-	PUNCT
admet-923	639	16	depth	depth	NOUN
admet-923	639	17	understanding	understanding	NOUN
admet-923	639	18	of	of	ADP
admet-923	639	19	gastrointestinal	gastrointestinal	ADJ
admet-923	639	20	physiology	physiology	NOUN
admet-923	639	21	is	be	AUX
admet-923	639	22	critically	critically	ADV
admet-923	639	23	important	important	ADJ
admet-923	640	1	[	[	X
admet-923	640	2	165,180,181	165,180,181	NUM
admet-923	640	3	]	]	PUNCT
admet-923	640	4	.	.	PUNCT
admet-923	641	1	physiological	physiological	ADJ
admet-923	641	2	parameters	parameter	NOUN
admet-923	641	3	reported	report	VERB
admet-923	641	4	in	in	ADP
admet-923	641	5	the	the	DET
admet-923	641	6	literature	literature	NOUN
admet-923	641	7	have	have	VERB
admet-923	641	8	large	large	ADJ
admet-923	641	9	variations	variation	NOUN
admet-923	641	10	,	,	PUNCT
admet-923	641	11	for	for	ADP
admet-923	641	12	example	example	NOUN
admet-923	641	13	,	,	PUNCT
admet-923	641	14	in	in	ADP
admet-923	641	15	gastric	gastric	ADJ
admet-923	641	16	ph	ph	VERB
admet-923	641	17	,	,	PUNCT
admet-923	641	18	intestinal	intestinal	ADJ
admet-923	641	19	ph	ph	ADJ
admet-923	641	20	,	,	PUNCT
admet-923	641	21	fluid	fluid	ADJ
admet-923	641	22	volumes	volume	NOUN
admet-923	641	23	,	,	PUNCT
admet-923	641	24	bile	bile	NOUN
admet-923	641	25	concentration	concentration	NOUN
admet-923	641	26	,	,	PUNCT
admet-923	641	27	and	and	CCONJ
admet-923	641	28	buffer	buffer	VERB
admet-923	641	29	capacity	capacity	NOUN
admet-923	641	30	[	[	X
admet-923	641	31	27,182	27,182	NUM
admet-923	641	32	]	]	PUNCT
admet-923	641	33	.	.	PUNCT
admet-923	642	1	it	it	PRON
admet-923	642	2	is	be	AUX
admet-923	642	3	a	a	DET
admet-923	642	4	combination	combination	NOUN
admet-923	642	5	of	of	ADP
admet-923	642	6	experimental	experimental	ADJ
admet-923	642	7	uncertainty	uncertainty	NOUN
admet-923	642	8	,	,	PUNCT
admet-923	642	9	true	true	ADJ
admet-923	642	10	inter	inter	ADJ
admet-923	642	11	-	-	ADJ
admet-923	642	12	subject	subject	ADJ
admet-923	642	13	variability	variability	NOUN
admet-923	642	14	and	and	CCONJ
admet-923	642	15	true	true	ADJ
admet-923	642	16	inter	inter	ADJ
admet-923	642	17	-	-	ADJ
admet-923	642	18	occasion	occasion	ADJ
admet-923	642	19	variability	variability	NOUN
admet-923	642	20	.	.	PUNCT
admet-923	643	1	the	the	DET
admet-923	643	2	buffer	buffer	NOUN
admet-923	643	3	capacity	capacity	NOUN
admet-923	643	4	of	of	ADP
admet-923	643	5	compendial	compendial	ADJ
admet-923	643	6	dissolution	dissolution	NOUN
admet-923	643	7	media	medium	NOUN
admet-923	643	8	(	(	PUNCT
admet-923	643	9	phosphate	phosphate	ADJ
admet-923	643	10	buffer	buffer	NOUN
admet-923	643	11	)	)	PUNCT
admet-923	643	12	is	be	AUX
admet-923	643	13	markedly	markedly	ADV
admet-923	643	14	higher	high	ADJ
admet-923	643	15	than	than	ADP
admet-923	643	16	the	the	DET
admet-923	643	17	real	real	ADJ
admet-923	643	18	intestinal	intestinal	ADJ
admet-923	643	19	fluid	fluid	NOUN
admet-923	643	20	(	(	PUNCT
admet-923	643	21	bicarbonate	bicarbonate	NOUN
admet-923	643	22	buffer	buffer	NOUN
admet-923	643	23	)	)	PUNCT
admet-923	643	24	,	,	PUNCT
admet-923	643	25	affecting	affect	VERB
admet-923	643	26	the	the	DET
admet-923	643	27	dissolution	dissolution	ADJ
admet-923	643	28	profiles	profile	NOUN
admet-923	643	29	of	of	ADP
admet-923	643	30	drugs	drug	NOUN
admet-923	643	31	[	[	X
admet-923	643	32	61,183–186	61,183–186	NUM
admet-923	643	33	]	]	PUNCT
admet-923	643	34	.	.	PUNCT
admet-923	644	1	the	the	DET
admet-923	644	2	intestinal	intestinal	ADJ
admet-923	644	3	fluid	fluid	NOUN
admet-923	644	4	volume	volume	NOUN
admet-923	644	5	(	(	PUNCT
admet-923	644	6	vsi	vsi	PROPN
admet-923	644	7	)	)	PUNCT
admet-923	644	8	would	would	AUX
admet-923	644	9	be	be	AUX
admet-923	644	10	much	much	ADV
admet-923	644	11	smaller	small	ADJ
admet-923	644	12	than	than	SCONJ
admet-923	644	13	originally	originally	ADV
admet-923	644	14	thought	think	VERB
admet-923	644	15	[	[	X
admet-923	644	16	25–29	25–29	NOUN
admet-923	644	17	]	]	X
admet-923	644	18	(	(	PUNCT
admet-923	644	19	note	note	VERB
admet-923	644	20	that	that	SCONJ
admet-923	644	21	a	a	DET
admet-923	644	22	vsi	vsi	PROPN
admet-923	644	23	value	value	NOUN
admet-923	644	24	(	(	PUNCT
admet-923	644	25	212	212	NUM
admet-923	644	26	ml	ml	NOUN
admet-923	644	27	)	)	PUNCT
admet-923	644	28	had	have	AUX
admet-923	644	29	already	already	ADV
admet-923	644	30	been	be	AUX
admet-923	644	31	reported	report	VERB
admet-923	644	32	as	as	ADV
admet-923	644	33	early	early	ADV
admet-923	644	34	as	as	ADP
admet-923	644	35	1957	1957	NUM
admet-923	644	36	)	)	PUNCT
admet-923	645	1	[	[	X
admet-923	645	2	26,27	26,27	NUM
admet-923	645	3	]	]	PUNCT
admet-923	645	4	.	.	PUNCT
admet-923	646	1	the	the	DET
admet-923	646	2	gastric	gastric	ADJ
admet-923	646	3	and	and	CCONJ
admet-923	646	4	intestinal	intestinal	ADJ
admet-923	646	5	phs	phs	NOUN
admet-923	646	6	of	of	ADP
admet-923	646	7	dogs	dog	NOUN
admet-923	646	8	are	be	AUX
admet-923	646	9	significantly	significantly	ADV
admet-923	646	10	different	different	ADJ
admet-923	646	11	from	from	ADP
admet-923	646	12	those	those	PRON
admet-923	646	13	in	in	ADP
admet-923	646	14	humans	human	NOUN
admet-923	646	15	[	[	X
admet-923	646	16	50,187–190	50,187–190	PROPN
admet-923	646	17	]	]	PUNCT
admet-923	646	18	.	.	PUNCT
admet-923	647	1	harmonization	harmonization	NOUN
admet-923	647	2	in	in	ADP
admet-923	647	3	the	the	DET
admet-923	647	4	future	future	NOUN
admet-923	647	5	,	,	PUNCT
admet-923	647	6	it	it	PRON
admet-923	647	7	is	be	AUX
admet-923	647	8	desirable	desirable	ADJ
admet-923	647	9	to	to	PART
admet-923	647	10	harmonize	harmonize	VERB
admet-923	647	11	physiological	physiological	ADJ
admet-923	647	12	parameters	parameter	NOUN
admet-923	647	13	and	and	CCONJ
admet-923	647	14	model	model	NOUN
admet-923	647	15	equations	equation	NOUN
admet-923	647	16	for	for	ADP
admet-923	647	17	regulatory	regulatory	ADJ
admet-923	647	18	submission	submission	NOUN
admet-923	647	19	(	(	PUNCT
admet-923	647	20	section	section	NOUN
admet-923	647	21	1.2	1.2	NUM
admet-923	647	22	and	and	CCONJ
admet-923	647	23	2.1	2.1	NUM
admet-923	647	24	)	)	PUNCT
admet-923	647	25	.	.	PUNCT
admet-923	648	1	in	in	ADP
admet-923	648	2	addition	addition	NOUN
admet-923	648	3	,	,	PUNCT
admet-923	648	4	drug	drug	NOUN
admet-923	648	5	intrinsic	intrinsic	ADJ
admet-923	648	6	parameters	parameter	NOUN
admet-923	648	7	such	such	ADJ
admet-923	648	8	as	as	ADP
admet-923	648	9	s0	s0	NOUN
admet-923	648	10	,	,	PUNCT
admet-923	648	11	p	p	X
admet-923	648	12	trans0	trans0	NOUN
admet-923	648	13	,	,	PUNCT
admet-923	648	14	and	and	CCONJ
admet-923	648	15	kbm	kbm	NOUN
admet-923	648	16	(	(	PUNCT
admet-923	648	17	section	section	NOUN
admet-923	648	18	2.1	2.1	NUM
admet-923	648	19	)	)	PUNCT
admet-923	648	20	,	,	PUNCT
admet-923	648	21	should	should	AUX
admet-923	648	22	be	be	AUX
admet-923	648	23	obtained	obtain	VERB
admet-923	648	24	using	use	VERB
admet-923	648	25	harmonized	harmonized	ADJ
admet-923	648	26	procedures	procedure	NOUN
admet-923	648	27	[	[	X
admet-923	648	28	109	109	NUM
admet-923	648	29	]	]	PUNCT
admet-923	648	30	.	.	PUNCT
admet-923	649	1	currently	currently	ADV
admet-923	649	2	,	,	PUNCT
admet-923	649	3	the	the	DET
admet-923	649	4	prediction	prediction	NOUN
admet-923	649	5	characteristics	characteristic	NOUN
admet-923	649	6	of	of	ADP
admet-923	649	7	commercial	commercial	ADJ
admet-923	649	8	software	software	NOUN
admet-923	649	9	products	product	NOUN
admet-923	649	10	vary	vary	VERB
admet-923	649	11	from	from	ADP
admet-923	649	12	product	product	NOUN
admet-923	649	13	to	to	ADP
admet-923	649	14	product	product	NOUN
admet-923	649	15	[	[	X
admet-923	649	16	5	5	NUM
admet-923	649	17	]	]	PUNCT
admet-923	649	18	.	.	PUNCT
admet-923	650	1	if	if	SCONJ
admet-923	650	2	two	two	NUM
admet-923	650	3	software	software	NOUN
admet-923	650	4	products	product	NOUN
admet-923	650	5	predict	predict	VERB
admet-923	650	6	different	different	ADJ
admet-923	650	7	outcomes	outcome	NOUN
admet-923	650	8	,	,	PUNCT
admet-923	650	9	which	which	DET
admet-923	650	10	one	one	PRON
admet-923	650	11	should	should	AUX
admet-923	650	12	be	be	AUX
admet-923	650	13	used	use	VERB
admet-923	650	14	for	for	ADP
admet-923	650	15	regulatory	regulatory	ADJ
admet-923	650	16	purposes	purpose	NOUN
admet-923	650	17	?	?	PUNCT
admet-923	651	1	in	in	ADP
admet-923	651	2	the	the	DET
admet-923	651	3	field	field	NOUN
admet-923	651	4	of	of	ADP
admet-923	651	5	biopharmaceutics	biopharmaceutics	NOUN
admet-923	651	6	,	,	PUNCT
admet-923	651	7	the	the	DET
admet-923	651	8	procedures	procedure	NOUN
admet-923	651	9	and	and	CCONJ
admet-923	651	10	conditions	condition	NOUN
admet-923	651	11	for	for	ADP
admet-923	651	12	dissolution	dissolution	NOUN
admet-923	651	13	tests	test	NOUN
admet-923	651	14	[	[	X
admet-923	651	15	191,192	191,192	NUM
admet-923	651	16	]	]	X
admet-923	651	17	,	,	PUNCT
admet-923	651	18	in	in	ADP
admet-923	651	19	vitro	vitro	X
admet-923	651	20	–	–	PUNCT
admet-923	651	21	in	in	ADP
admet-923	651	22	vivo	vivo	ADJ
admet-923	651	23	correlation	correlation	NOUN
admet-923	651	24	[	[	X
admet-923	651	25	193,194	193,194	NUM
admet-923	651	26	]	]	PUNCT
admet-923	651	27	,	,	PUNCT
admet-923	651	28	the	the	DET
admet-923	651	29	biowaiver	biowaiver	PROPN
admet-923	651	30	scheme	scheme	NOUN
admet-923	651	31	[	[	X
admet-923	651	32	195	195	NUM
admet-923	651	33	]	]	PUNCT
admet-923	651	34	,	,	PUNCT
admet-923	651	35	etc	etc	X
admet-923	651	36	.	.	X
admet-923	651	37	have	have	AUX
admet-923	651	38	been	be	AUX
admet-923	651	39	harmonized	harmonize	VERB
admet-923	651	40	and	and	CCONJ
admet-923	651	41	standardized	standardize	VERB
admet-923	651	42	.	.	PUNCT
admet-923	652	1	similarly	similarly	ADV
admet-923	652	2	,	,	PUNCT
admet-923	652	3	oa	oa	ADP
admet-923	652	4	pbpk	pbpk	NOUN
admet-923	652	5	modelling	modelling	NOUN
admet-923	652	6	should	should	AUX
admet-923	652	7	be	be	AUX
admet-923	652	8	harmonized	harmonize	VERB
admet-923	652	9	based	base	VERB
admet-923	652	10	on	on	ADP
admet-923	652	11	proper	proper	ADJ
admet-923	652	12	model	model	NOUN
admet-923	652	13	evaluation	evaluation	NOUN
admet-923	652	14	in	in	ADP
admet-923	652	15	the	the	DET
admet-923	652	16	future	future	NOUN
admet-923	652	17	(	(	PUNCT
admet-923	652	18	section	section	NOUN
admet-923	652	19	2.4	2.4	NUM
admet-923	652	20	)	)	PUNCT
admet-923	652	21	.	.	PUNCT
admet-923	653	1	we	we	PRON
admet-923	653	2	may	may	AUX
admet-923	653	3	also	also	ADV
admet-923	653	4	need	need	VERB
admet-923	653	5	a	a	DET
admet-923	653	6	good	good	ADJ
admet-923	653	7	simulation	simulation	NOUN
admet-923	653	8	practice	practice	NOUN
admet-923	653	9	when	when	SCONJ
admet-923	653	10	pbpk	pbpk	NOUN
admet-923	653	11	modelling	modelling	NOUN
admet-923	653	12	is	be	AUX
admet-923	653	13	used	use	VERB
admet-923	653	14	to	to	PART
admet-923	653	15	waive	waive	VERB
admet-923	653	16	a	a	DET
admet-923	653	17	clinical	clinical	ADJ
admet-923	653	18	study	study	NOUN
admet-923	654	1	[	[	X
admet-923	654	2	35,36	35,36	NUM
admet-923	654	3	]	]	PUNCT
admet-923	654	4	.	.	PUNCT
admet-923	655	1	https://doi.org/10.5599/admet.923	https://doi.org/10.5599/admet.923	X
admet-923	655	2	kiyohiko	kiyohiko	PROPN
admet-923	655	3	sugano	sugano	PROPN
admet-923	655	4	admet	admet	PROPN
admet-923	655	5	&	&	CCONJ
admet-923	655	6	dmpk	dmpk	PROPN
admet-923	655	7	9(2	9(2	NUM
admet-923	655	8	)	)	PUNCT
admet-923	655	9	(	(	PUNCT
admet-923	655	10	2021	2021	NUM
admet-923	655	11	)	)	PUNCT
admet-923	655	12	75	75	NUM
admet-923	655	13	-	-	SYM
admet-923	655	14	109	109	NUM
admet-923	655	15	98	98	NUM
admet-923	655	16	not	not	PART
admet-923	655	17	to	to	PART
admet-923	655	18	be	be	AUX
admet-923	655	19	lost	lose	VERB
admet-923	655	20	in	in	ADP
admet-923	655	21	modelling	modelling	NOUN
admet-923	655	22	and	and	CCONJ
admet-923	655	23	simulation	simulation	NOUN
admet-923	655	24	“	"	PUNCT
admet-923	655	25	the	the	DET
admet-923	655	26	greatest	great	ADJ
admet-923	655	27	enemy	enemy	NOUN
admet-923	655	28	of	of	ADP
admet-923	655	29	knowledge	knowledge	NOUN
admet-923	655	30	is	be	AUX
admet-923	655	31	not	not	PART
admet-923	655	32	ignorance	ignorance	NOUN
admet-923	655	33	;	;	PUNCT
admet-923	655	34	it	it	PRON
admet-923	655	35	is	be	AUX
admet-923	655	36	the	the	DET
admet-923	655	37	illusion	illusion	NOUN
admet-923	655	38	of	of	ADP
admet-923	655	39	knowledge	knowledge	NOUN
admet-923	655	40	”	"	PUNCT
admet-923	655	41	daniel	daniel	PROPN
admet-923	655	42	boorstin/	boorstin/	NUM
admet-923	655	43	stephen	stephen	PROPN
admet-923	655	44	hawking	hawk	VERB
admet-923	655	45	when	when	SCONJ
admet-923	655	46	the	the	DET
admet-923	655	47	“	"	PUNCT
admet-923	655	48	bottom	bottom	ADJ
admet-923	655	49	-	-	PUNCT
admet-923	655	50	up	up	NOUN
admet-923	655	51	”	"	PUNCT
admet-923	655	52	simulation	simulation	NOUN
admet-923	655	53	deviates	deviate	VERB
admet-923	655	54	from	from	ADP
admet-923	655	55	the	the	DET
admet-923	655	56	clinical	clinical	ADJ
admet-923	655	57	data	datum	NOUN
admet-923	655	58	,	,	PUNCT
admet-923	655	59	simply	simply	ADV
admet-923	655	60	press	press	VERB
admet-923	655	61	the	the	DET
admet-923	655	62	"	"	PUNCT
admet-923	655	63	optimize	optimize	NOUN
admet-923	655	64	"	"	PUNCT
admet-923	655	65	button	button	NOUN
admet-923	655	66	and	and	CCONJ
admet-923	655	67	the	the	DET
admet-923	655	68	monitor	monitor	NOUN
admet-923	655	69	will	will	AUX
admet-923	655	70	display	display	VERB
admet-923	655	71	a	a	DET
admet-923	655	72	simulation	simulation	NOUN
admet-923	655	73	curve	curve	NOUN
admet-923	655	74	that	that	PRON
admet-923	655	75	exactly	exactly	ADV
admet-923	655	76	matches	match	VERB
admet-923	655	77	the	the	DET
admet-923	655	78	clinical	clinical	ADJ
admet-923	655	79	plasma	plasma	NOUN
admet-923	655	80	concentration	concentration	NOUN
admet-923	655	81	(	(	PUNCT
admet-923	655	82	cp	cp	NOUN
admet-923	655	83	)	)	PUNCT
admet-923	655	84	time	time	NOUN
admet-923	655	85	data	datum	NOUN
admet-923	655	86	.	.	PUNCT
admet-923	656	1	if	if	SCONJ
admet-923	656	2	we	we	PRON
admet-923	656	3	continue	continue	VERB
admet-923	656	4	publishing	publish	VERB
admet-923	656	5	this	this	PRON
admet-923	656	6	as	as	ADP
admet-923	656	7	a	a	DET
admet-923	656	8	successful	successful	ADJ
admet-923	656	9	"	"	PUNCT
admet-923	656	10	prediction	prediction	NOUN
admet-923	656	11	"	"	PUNCT
admet-923	656	12	,	,	PUNCT
admet-923	656	13	it	it	PRON
admet-923	656	14	will	will	AUX
admet-923	656	15	eventually	eventually	ADV
admet-923	656	16	cause	cause	VERB
admet-923	656	17	the	the	DET
admet-923	656	18	illusion	illusion	NOUN
admet-923	656	19	of	of	ADP
admet-923	656	20	a	a	DET
admet-923	656	21	prediction	prediction	NOUN
admet-923	656	22	paradise	paradise	NOUN
admet-923	656	23	.	.	PUNCT
admet-923	657	1	we	we	PRON
admet-923	657	2	must	must	AUX
admet-923	657	3	exert	exert	VERB
admet-923	657	4	extreme	extreme	ADJ
admet-923	657	5	caution	caution	NOUN
admet-923	657	6	not	not	PART
admet-923	657	7	to	to	PART
admet-923	657	8	be	be	AUX
admet-923	657	9	lost	lose	VERB
admet-923	657	10	in	in	ADP
admet-923	657	11	modelling	modelling	NOUN
admet-923	657	12	and	and	CCONJ
admet-923	657	13	simulation	simulation	NOUN
admet-923	657	14	.	.	PUNCT
admet-923	658	1	model	model	PROPN
admet-923	658	2	equations	equation	NOUN
admet-923	658	3	,	,	PUNCT
admet-923	658	4	physiological	physiological	ADJ
admet-923	658	5	parameters	parameter	NOUN
admet-923	658	6	,	,	PUNCT
admet-923	658	7	and	and	CCONJ
admet-923	658	8	drug	drug	NOUN
admet-923	658	9	parameters	parameter	NOUN
admet-923	658	10	must	must	AUX
admet-923	658	11	be	be	AUX
admet-923	658	12	disclosed	disclose	VERB
admet-923	658	13	to	to	PART
admet-923	658	14	ensure	ensure	VERB
admet-923	658	15	proper	proper	ADJ
admet-923	658	16	peer	peer	NOUN
admet-923	658	17	-	-	PUNCT
admet-923	658	18	review	review	NOUN
admet-923	658	19	and	and	CCONJ
admet-923	658	20	reproducibility	reproducibility	NOUN
admet-923	658	21	.	.	PUNCT
admet-923	659	1	a	a	DET
admet-923	659	2	systematic	systematic	ADJ
admet-923	659	3	evaluation	evaluation	NOUN
admet-923	659	4	of	of	ADP
admet-923	659	5	predictive	predictive	ADJ
admet-923	659	6	power	power	NOUN
admet-923	659	7	is	be	AUX
admet-923	659	8	required	require	VERB
admet-923	659	9	to	to	PART
admet-923	659	10	avoid	avoid	VERB
admet-923	659	11	publication	publication	NOUN
admet-923	659	12	bias	bias	NOUN
admet-923	659	13	.	.	PUNCT
admet-923	660	1	when	when	SCONJ
admet-923	660	2	a	a	DET
admet-923	660	3	middle	middle	ADJ
admet-923	660	4	-	-	PUNCT
admet-923	660	5	out	out	ADP
admet-923	660	6	approach	approach	NOUN
admet-923	660	7	is	be	AUX
admet-923	660	8	pursued	pursue	VERB
admet-923	660	9	,	,	PUNCT
admet-923	660	10	the	the	DET
admet-923	660	11	fitted	fit	VERB
admet-923	660	12	cp	cp	NOUN
admet-923	660	13	time	time	NOUN
admet-923	660	14	curve	curve	NOUN
admet-923	660	15	must	must	AUX
admet-923	660	16	be	be	AUX
admet-923	660	17	labelled	label	VERB
admet-923	660	18	as	as	ADP
admet-923	660	19	"	"	PUNCT
admet-923	660	20	fitted	fit	VERB
admet-923	660	21	"	"	PUNCT
admet-923	660	22	(	(	PUNCT
admet-923	660	23	not	not	PART
admet-923	660	24	"	"	PUNCT
admet-923	660	25	predicted	predict	VERB
admet-923	660	26	"	"	PUNCT
admet-923	660	27	)	)	PUNCT
admet-923	660	28	.	.	PUNCT
admet-923	661	1	parameter	parameter	NOUN
admet-923	661	2	identifiability	identifiability	NOUN
admet-923	661	3	should	should	AUX
admet-923	661	4	be	be	AUX
admet-923	661	5	carefully	carefully	ADV
admet-923	661	6	considered	consider	VERB
admet-923	661	7	.	.	PUNCT
admet-923	662	1	the	the	DET
admet-923	662	2	optimized	optimize	VERB
admet-923	662	3	model	model	NOUN
admet-923	662	4	must	must	AUX
admet-923	662	5	be	be	AUX
admet-923	662	6	validated	validate	VERB
admet-923	662	7	using	use	VERB
admet-923	662	8	independent	independent	ADJ
admet-923	662	9	clinical	clinical	ADJ
admet-923	662	10	pk	pk	NOUN
admet-923	662	11	data	datum	NOUN
admet-923	662	12	of	of	ADP
admet-923	662	13	the	the	DET
admet-923	662	14	context	context	NOUN
admet-923	662	15	of	of	ADP
admet-923	662	16	use	use	NOUN
admet-923	662	17	.	.	PUNCT
admet-923	663	1	finally	finally	ADV
admet-923	663	2	,	,	PUNCT
admet-923	663	3	and	and	CCONJ
admet-923	663	4	most	most	ADV
admet-923	663	5	importantly	importantly	ADV
admet-923	663	6	,	,	PUNCT
admet-923	663	7	pharmacokinetic	pharmacokinetic	ADJ
admet-923	663	8	,	,	PUNCT
admet-923	663	9	physical	physical	ADJ
admet-923	663	10	chemistry	chemistry	NOUN
admet-923	663	11	,	,	PUNCT
admet-923	663	12	formulation	formulation	NOUN
admet-923	663	13	,	,	PUNCT
admet-923	663	14	and	and	CCONJ
admet-923	663	15	physiology	physiology	NOUN
admet-923	663	16	experts	expert	NOUN
admet-923	663	17	should	should	AUX
admet-923	663	18	work	work	VERB
admet-923	663	19	together	together	ADV
admet-923	663	20	so	so	SCONJ
admet-923	663	21	that	that	SCONJ
admet-923	663	22	not	not	PART
admet-923	663	23	to	to	PART
admet-923	663	24	get	get	AUX
admet-923	663	25	lost	lose	VERB
admet-923	663	26	in	in	ADP
admet-923	663	27	modelling	modelling	NOUN
admet-923	663	28	and	and	CCONJ
admet-923	663	29	simulation	simulation	NOUN
admet-923	663	30	.	.	PUNCT
admet-923	664	1	as	as	SCONJ
admet-923	664	2	mentioned	mention	VERB
admet-923	664	3	in	in	ADP
admet-923	664	4	the	the	DET
admet-923	664	5	introduction	introduction	NOUN
admet-923	664	6	,	,	PUNCT
admet-923	664	7	when	when	SCONJ
admet-923	664	8	used	use	VERB
admet-923	664	9	correctly	correctly	ADV
admet-923	664	10	,	,	PUNCT
admet-923	664	11	oa	oa	ADP
admet-923	664	12	pbpk	pbpk	NOUN
admet-923	664	13	modeling	modeling	NOUN
admet-923	664	14	will	will	AUX
admet-923	664	15	be	be	AUX
admet-923	664	16	an	an	DET
admet-923	664	17	excellent	excellent	ADJ
admet-923	664	18	tool	tool	NOUN
admet-923	664	19	for	for	ADP
admet-923	664	20	understanding	understanding	NOUN
admet-923	664	21	and	and	CCONJ
admet-923	664	22	predicting	predict	VERB
admet-923	664	23	the	the	DET
admet-923	664	24	oral	oral	ADJ
admet-923	664	25	absorption	absorption	NOUN
admet-923	664	26	of	of	ADP
admet-923	664	27	a	a	DET
admet-923	664	28	drug	drug	NOUN
admet-923	664	29	.	.	PUNCT
admet-923	665	1	this	this	DET
admet-923	665	2	article	article	NOUN
admet-923	665	3	will	will	AUX
admet-923	665	4	hopefully	hopefully	ADV
admet-923	665	5	enhance	enhance	VERB
admet-923	665	6	the	the	DET
admet-923	665	7	science	science	NOUN
admet-923	665	8	of	of	ADP
admet-923	665	9	oa	oa	PROPN
admet-923	665	10	pbpk	pbpk	NOUN
admet-923	665	11	modelling	modelling	NOUN
admet-923	665	12	in	in	ADP
admet-923	665	13	the	the	DET
admet-923	665	14	future	future	NOUN
admet-923	665	15	.	.	PUNCT
admet-923	666	1	acknowledgement	acknowledgement	NOUN
admet-923	666	2	i	i	PRON
admet-923	666	3	would	would	AUX
admet-923	666	4	like	like	VERB
admet-923	666	5	to	to	PART
admet-923	666	6	thank	thank	VERB
admet-923	666	7	prof	prof	PROPN
admet-923	666	8	.	.	PUNCT
admet-923	667	1	kin	kin	PROPN
admet-923	667	2	tam	tam	PROPN
admet-923	667	3	and	and	CCONJ
admet-923	667	4	prof	prof	PROPN
admet-923	667	5	.	.	PUNCT
admet-923	668	1	zoran	zoran	PROPN
admet-923	668	2	mandić	mandić	PROPN
admet-923	668	3	for	for	ADP
admet-923	668	4	giving	give	VERB
admet-923	668	5	me	i	PRON
admet-923	668	6	this	this	DET
admet-923	668	7	opportunity	opportunity	NOUN
admet-923	668	8	to	to	PART
admet-923	668	9	write	write	VERB
admet-923	668	10	this	this	DET
admet-923	668	11	article	article	NOUN
admet-923	668	12	.	.	PUNCT
admet-923	669	1	i	i	PRON
admet-923	669	2	would	would	AUX
admet-923	669	3	like	like	VERB
admet-923	669	4	to	to	PART
admet-923	669	5	thank	thank	VERB
admet-923	669	6	dr	dr	PROPN
admet-923	669	7	.	.	PROPN
admet-923	669	8	alex	alex	PROPN
admet-923	669	9	avdeef	avdeef	PROPN
admet-923	669	10	,	,	PUNCT
admet-923	669	11	dr	dr	PROPN
admet-923	669	12	.	.	PROPN
admet-923	669	13	zahari	zahari	PROPN
admet-923	669	14	vinarov	vinarov	PROPN
admet-923	669	15	,	,	PUNCT
admet-923	669	16	and	and	CCONJ
admet-923	669	17	prof	prof	PROPN
admet-923	669	18	.	.	PUNCT
admet-923	670	1	shinji	shinji	PROPN
admet-923	670	2	yamashita	yamashita	PROPN
admet-923	670	3	for	for	ADP
admet-923	670	4	their	their	PRON
admet-923	670	5	valuable	valuable	ADJ
admet-923	670	6	and	and	CCONJ
admet-923	670	7	encouraging	encouraging	ADJ
admet-923	670	8	comments	comment	NOUN
admet-923	670	9	.	.	PUNCT
admet-923	671	1	this	this	DET
admet-923	671	2	article	article	NOUN
admet-923	671	3	is	be	AUX
admet-923	671	4	inspired	inspire	VERB
admet-923	671	5	by	by	ADP
admet-923	671	6	the	the	DET
admet-923	671	7	discussions	discussion	NOUN
admet-923	671	8	in	in	ADP
admet-923	671	9	the	the	DET
admet-923	671	10	consortium	consortium	NOUN
admet-923	671	11	of	of	ADP
admet-923	671	12	biopharmaceutical	biopharmaceutical	ADJ
admet-923	671	13	tools	tool	NOUN
admet-923	671	14	(	(	PUNCT
admet-923	671	15	cobito	cobito	ADJ
admet-923	671	16	)	)	PUNCT
admet-923	671	17	project	project	NOUN
admet-923	671	18	in	in	ADP
admet-923	671	19	consortium	consortium	NOUN
admet-923	671	20	of	of	ADP
admet-923	671	21	pharmaceutical	pharmaceutical	NOUN
admet-923	671	22	technology	technology	NOUN
admet-923	671	23	,	,	PUNCT
admet-923	671	24	research	research	NOUN
admet-923	671	25	center	center	NOUN
admet-923	671	26	for	for	ADP
admet-923	671	27	drug	drug	NOUN
admet-923	671	28	discovery	discovery	NOUN
admet-923	671	29	and	and	CCONJ
admet-923	671	30	development	development	NOUN
admet-923	671	31	science	science	NOUN
admet-923	671	32	at	at	ADP
admet-923	671	33	ritsumeikan	ritsumeikan	PROPN
admet-923	671	34	university	university	NOUN
admet-923	671	35	.	.	PUNCT
admet-923	672	1	the	the	DET
admet-923	672	2	author	author	NOUN
admet-923	672	3	would	would	AUX
admet-923	672	4	like	like	VERB
admet-923	672	5	to	to	PART
admet-923	672	6	thank	thank	VERB
admet-923	672	7	all	all	DET
admet-923	672	8	cobito	cobito	ADJ
admet-923	672	9	members	member	NOUN
admet-923	672	10	,	,	PUNCT
admet-923	672	11	especially	especially	ADV
admet-923	672	12	mr	mr	PROPN
admet-923	672	13	.	.	PROPN
admet-923	672	14	naoya	naoya	PROPN
admet-923	673	1	matsumura	matsumura	PROPN
admet-923	673	2	,	,	PUNCT
admet-923	673	3	mr	mr	PROPN
admet-923	673	4	.	.	PROPN
admet-923	673	5	yoshiyuki	yoshiyuki	PROPN
admet-923	673	6	akiyama	akiyama	PROPN
admet-923	673	7	,	,	PUNCT
admet-923	673	8	ms	ms	PROPN
admet-923	673	9	.	.	PROPN
admet-923	673	10	asami	asami	PROPN
admet-923	673	11	ono	ono	PROPN
admet-923	673	12	,	,	PUNCT
admet-923	673	13	and	and	CCONJ
admet-923	673	14	mr	mr	PROPN
admet-923	673	15	.	.	PROPN
admet-923	673	16	shun	shun	PROPN
admet-923	673	17	hayashi	hayashi	PROPN
admet-923	673	18	.	.	PUNCT
admet-923	674	1	the	the	DET
admet-923	674	2	cobito	cobito	ADJ
admet-923	674	3	members	member	NOUN
admet-923	674	4	are	be	AUX
admet-923	674	5	from	from	ADP
admet-923	674	6	asahi	asahi	PROPN
admet-923	674	7	kasei	kasei	PROPN
admet-923	674	8	pharma	pharma	PROPN
admet-923	674	9	corporation	corporation	NOUN
admet-923	674	10	,	,	PUNCT
admet-923	674	11	daiichi	daiichi	PROPN
admet-923	674	12	sankyo	sankyo	PROPN
admet-923	674	13	company	company	PROPN
admet-923	674	14	,	,	PUNCT
admet-923	674	15	limited	limited	ADJ
admet-923	674	16	,	,	PUNCT
admet-923	674	17	daiichi	daiichi	PROPN
admet-923	674	18	sankyo	sankyo	PROPN
admet-923	674	19	rd	rd	PROPN
admet-923	674	20	novare	novare	PROPN
admet-923	674	21	co.	co.	PROPN
admet-923	674	22	,	,	PUNCT
admet-923	674	23	ltd	ltd	PROPN
admet-923	674	24	.	.	PROPN
admet-923	674	25	,	,	PUNCT
admet-923	674	26	japan	japan	PROPN
admet-923	674	27	machinery	machinery	PROPN
admet-923	674	28	co.	co.	PROPN
admet-923	674	29	,	,	PUNCT
admet-923	674	30	ltd	ltd	PROPN
admet-923	674	31	.	.	PROPN
admet-923	674	32	,	,	PUNCT
admet-923	674	33	japan	japan	PROPN
admet-923	674	34	tobacco	tobacco	PROPN
admet-923	674	35	inc	inc	PROPN
admet-923	674	36	.	.	PROPN
admet-923	674	37	,	,	PUNCT
admet-923	674	38	mitsubishi	mitsubishi	PROPN
admet-923	674	39	tanabe	tanabe	PROPN
admet-923	674	40	pharma	pharma	PROPN
admet-923	674	41	corporation	corporation	PROPN
admet-923	674	42	,	,	PUNCT
admet-923	674	43	nippon	nippon	PROPN
admet-923	674	44	boehringer	boehringer	PROPN
admet-923	674	45	ingelheim	ingelheim	PROPN
admet-923	674	46	co.	co.	PROPN
admet-923	674	47	,	,	PUNCT
admet-923	674	48	ltd	ltd	PROPN
admet-923	674	49	.	.	PROPN
admet-923	674	50	,	,	PUNCT
admet-923	674	51	ono	ono	PROPN
admet-923	674	52	pharmaceutical	pharmaceutical	PROPN
admet-923	674	53	co.	co.	PROPN
admet-923	674	54	,	,	PUNCT
admet-923	674	55	ltd	ltd	PROPN
admet-923	674	56	.	.	PROPN
admet-923	674	57	,	,	PUNCT
admet-923	674	58	ritsumeikan	ritsumeikan	PROPN
admet-923	674	59	university	university	PROPN
admet-923	674	60	,	,	PUNCT
admet-923	674	61	sawai	sawai	PROPN
admet-923	674	62	pharmaceutical	pharmaceutical	PROPN
admet-923	674	63	co.	co.	PROPN
admet-923	674	64	,	,	PUNCT
admet-923	674	65	ltd	ltd	PROPN
admet-923	674	66	.	.	PROPN
admet-923	674	67	,	,	PUNCT
admet-923	674	68	shionogi	shionogi	PROPN
admet-923	674	69	&	&	CCONJ
admet-923	674	70	co.	co.	PROPN
admet-923	674	71	,	,	PUNCT
admet-923	674	72	ltd	ltd	PROPN
admet-923	674	73	.	.	PROPN
admet-923	674	74	,	,	PUNCT
admet-923	674	75	sumitomo	sumitomo	PROPN
admet-923	674	76	dainippon	dainippon	PROPN
admet-923	674	77	pharma	pharma	PROPN
admet-923	674	78	co.	co.	PROPN
admet-923	674	79	,	,	PUNCT
admet-923	674	80	ltd	ltd	PROPN
admet-923	674	81	.	.	PROPN
admet-923	674	82	,	,	PUNCT
admet-923	674	83	and	and	CCONJ
admet-923	674	84	towa	towa	PROPN
admet-923	674	85	pharmaceutical	pharmaceutical	PROPN
admet-923	674	86	co.	co.	PROPN
admet-923	674	87	,	,	PUNCT
admet-923	674	88	ltd	ltd	PROPN
admet-923	674	89	.	.	PROPN
admet-923	675	1	(	(	PUNCT
admet-923	675	2	in	in	ADP
admet-923	675	3	alphabetical	alphabetical	ADJ
admet-923	675	4	order	order	NOUN
admet-923	675	5	)	)	PUNCT
admet-923	675	6	.	.	PUNCT
admet-923	676	1	conflict	conflict	NOUN
admet-923	676	2	of	of	ADP
admet-923	676	3	interest	interest	NOUN
admet-923	676	4	kiyohiko	kiyohiko	PROPN
admet-923	676	5	sugano	sugano	PROPN
admet-923	676	6	is	be	AUX
admet-923	676	7	the	the	DET
admet-923	676	8	founder	founder	NOUN
admet-923	676	9	of	of	ADP
admet-923	676	10	bioavailabilitydesign	bioavailabilitydesign	PROPN
admet-923	676	11	llc	llc	PROPN
admet-923	676	12	.	.	PUNCT
admet-923	677	1	references	reference	NOUN
admet-923	677	2	[	[	X
admet-923	677	3	1	1	NUM
admet-923	677	4	]	]	PUNCT
admet-923	677	5	h.	h.	PROPN
admet-923	677	6	van	van	PROPN
admet-923	677	7	de	de	PROPN
admet-923	677	8	waterbeemd	waterbeemd	PROPN
admet-923	677	9	,	,	PUNCT
admet-923	677	10	e.	e.	PROPN
admet-923	677	11	gifford	gifford	PROPN
admet-923	677	12	.	.	PUNCT
admet-923	678	1	admet	admet	PROPN
admet-923	678	2	in	in	ADP
admet-923	678	3	silico	silico	NOUN
admet-923	678	4	modelling	modelling	NOUN
admet-923	678	5	:	:	PUNCT
admet-923	678	6	towards	towards	ADP
admet-923	678	7	prediction	prediction	NOUN
admet-923	678	8	paradise	paradise	PROPN
admet-923	678	9	?	?	PUNCT
admet-923	679	1	nat	nat	PROPN
admet-923	679	2	.	.	PUNCT
admet-923	680	1	rev	rev	PROPN
admet-923	680	2	.	.	PROPN
admet-923	680	3	drug	drug	NOUN
admet-923	680	4	discov	discov	NOUN
admet-923	680	5	.	.	PUNCT
admet-923	681	1	2	2	NUM
admet-923	681	2	(	(	PUNCT
admet-923	681	3	2003	2003	NUM
admet-923	681	4	)	)	PUNCT
admet-923	682	1	192–204	192–204	NUM
admet-923	682	2	.	.	PUNCT
admet-923	683	1	[	[	X
admet-923	683	2	2	2	NUM
admet-923	683	3	]	]	X
admet-923	683	4	a.s	a.s	PROPN
admet-923	683	5	.	.	PROPN
admet-923	683	6	darwich	darwich	PROPN
admet-923	683	7	,	,	PUNCT
admet-923	683	8	a.	a.	PROPN
admet-923	683	9	margolskee	margolskee	PROPN
admet-923	683	10	,	,	PUNCT
admet-923	683	11	x.	x.	PROPN
admet-923	683	12	pepin	pepin	PROPN
admet-923	683	13	,	,	PUNCT
admet-923	683	14	l.	l.	PROPN
admet-923	683	15	aarons	aarons	PROPN
admet-923	683	16	,	,	PUNCT
admet-923	683	17	a.	a.	NOUN
admet-923	683	18	galetin	galetin	PROPN
admet-923	683	19	,	,	PUNCT
admet-923	683	20	a.	a.	NOUN
admet-923	683	21	rostami	rostami	PROPN
admet-923	683	22	-	-	PUNCT
admet-923	683	23	hodjegan	hodjegan	PROPN
admet-923	683	24	,	,	PUNCT
admet-923	683	25	s.	s.	PROPN
admet-923	683	26	carlert	carlert	PROPN
admet-923	683	27	,	,	PUNCT
admet-923	683	28	m.	m.	PROPN
admet-923	683	29	hammarberg	hammarberg	PROPN
admet-923	683	30	,	,	PUNCT
admet-923	683	31	c.	c.	PROPN
admet-923	683	32	hilgendorf	hilgendorf	PROPN
admet-923	683	33	,	,	PUNCT
admet-923	683	34	p.	p.	PROPN
admet-923	683	35	johansson	johansson	PROPN
admet-923	683	36	,	,	PUNCT
admet-923	683	37	e.	e.	PROPN
admet-923	683	38	karlsson	karlsson	PROPN
admet-923	683	39	,	,	PUNCT
admet-923	683	40	d.	d.	PROPN
admet-923	683	41	murphy	murphy	PROPN
admet-923	683	42	,	,	PUNCT
admet-923	683	43	c.	c.	PROPN
admet-923	683	44	tannergren	tannergren	PROPN
admet-923	683	45	,	,	PUNCT
admet-923	683	46	h.	h.	PROPN
admet-923	683	47	thörn	thörn	PROPN
admet-923	683	48	,	,	PUNCT
admet-923	683	49	m.	m.	NOUN
admet-923	683	50	yasin	yasin	PROPN
admet-923	683	51	,	,	PUNCT
admet-923	683	52	f.	f.	PROPN
admet-923	683	53	mazuir	mazuir	PROPN
admet-923	683	54	,	,	PUNCT
admet-923	683	55	o.	o.	PROPN
admet-923	683	56	nicolas	nicolas	PROPN
admet-923	683	57	,	,	PUNCT
admet-923	683	58	s.	s.	PROPN
admet-923	683	59	ramusovic	ramusovic	PROPN
admet-923	683	60	,	,	PUNCT
admet-923	683	61	c.	c.	PROPN
admet-923	683	62	xu	xu	PROPN
admet-923	683	63	,	,	PUNCT
admet-923	683	64	s.m	s.m	PROPN
admet-923	683	65	.	.	PROPN
admet-923	683	66	pathak	pathak	PROPN
admet-923	683	67	,	,	PUNCT
admet-923	683	68	t.	t.	PROPN
admet-923	683	69	korjamo	korjamo	PROPN
admet-923	683	70	,	,	PUNCT
admet-923	683	71	j.	j.	PROPN
admet-923	683	72	laru	laru	PROPN
admet-923	683	73	,	,	PUNCT
admet-923	683	74	j.	j.	PROPN
admet-923	683	75	malkki	malkki	PROPN
admet-923	683	76	,	,	PUNCT
admet-923	683	77	s.	s.	PROPN
admet-923	683	78	pappinen	pappinen	PROPN
admet-923	683	79	,	,	PUNCT
admet-923	683	80	j.	j.	PROPN
admet-923	683	81	tuunainen	tuunainen	PROPN
admet-923	683	82	,	,	PUNCT
admet-923	683	83	j.	j.	PROPN
admet-923	683	84	dressman	dressman	PROPN
admet-923	683	85	,	,	PUNCT
admet-923	683	86	s.	s.	PROPN
admet-923	683	87	hansmann	hansmann	PROPN
admet-923	683	88	,	,	PUNCT
admet-923	683	89	e.	e.	PROPN
admet-923	683	90	kostewicz	kostewicz	PROPN
admet-923	683	91	,	,	PUNCT
admet-923	683	92	h.	h.	PROPN
admet-923	683	93	he	he	PROPN
admet-923	683	94	,	,	PUNCT
admet-923	683	95	t.	t.	PROPN
admet-923	683	96	heimbach	heimbach	PROPN
admet-923	683	97	,	,	PUNCT
admet-923	683	98	f.	f.	PROPN
admet-923	683	99	wu	wu	PROPN
admet-923	683	100	,	,	PUNCT
admet-923	683	101	c.	c.	PROPN
admet-923	683	102	hoft	hoft	PROPN
admet-923	683	103	,	,	PUNCT
admet-923	683	104	y.	y.	PROPN
admet-923	683	105	pang	pang	PROPN
admet-923	683	106	,	,	PUNCT
admet-923	683	107	m.b	m.b	PROPN
admet-923	683	108	.	.	PROPN
admet-923	683	109	admet	admet	PROPN
admet-923	683	110	&	&	CCONJ
admet-923	683	111	dmpk	dmpk	PROPN
admet-923	683	112	9(2	9(2	NUM
admet-923	683	113	)	)	PUNCT
admet-923	683	114	(	(	PUNCT
admet-923	683	115	2021	2021	NUM
admet-923	683	116	)	)	PUNCT
admet-923	683	117	75	75	NUM
admet-923	683	118	-	-	SYM
admet-923	683	119	109	109	NUM
admet-923	683	120	lost	lose	VERB
admet-923	683	121	in	in	ADP
admet-923	683	122	modelling	modelling	NOUN
admet-923	683	123	and	and	CCONJ
admet-923	683	124	simulation	simulation	NOUN
admet-923	683	125	?	?	PUNCT
admet-923	684	1	doi	doi	NOUN
admet-923	684	2	:	:	PUNCT
admet-923	684	3	https:/doi.org/10.5599	https:/doi.org/10.5599	PROPN
admet-923	684	4	/	/	SYM
admet-923	684	5	admet.923	admet.923	PROPN
admet-923	684	6	99	99	NUM
admet-923	684	7	bolger	bolger	NOUN
admet-923	684	8	,	,	PUNCT
admet-923	684	9	e.	e.	PROPN
admet-923	684	10	huehn	huehn	PROPN
admet-923	684	11	,	,	PUNCT
admet-923	684	12	v.	v.	PROPN
admet-923	684	13	lukacova	lukacova	PROPN
admet-923	684	14	,	,	PUNCT
admet-923	684	15	j.m	j.m	PROPN
admet-923	684	16	.	.	PROPN
admet-923	684	17	mullin	mullin	PROPN
admet-923	684	18	,	,	PUNCT
admet-923	684	19	k.x	k.x	PROPN
admet-923	684	20	.	.	PROPN
admet-923	684	21	szeto	szeto	PROPN
admet-923	684	22	,	,	PUNCT
admet-923	684	23	c.	c.	PROPN
admet-923	684	24	costales	costales	PROPN
admet-923	684	25	,	,	PUNCT
admet-923	684	26	j.	j.	PROPN
admet-923	684	27	lin	lin	PROPN
admet-923	684	28	,	,	PUNCT
admet-923	684	29	m.	m.	NOUN
admet-923	684	30	mcallister	mcallister	PROPN
admet-923	684	31	,	,	PUNCT
admet-923	684	32	s.	s.	PROPN
admet-923	684	33	modi	modi	PROPN
admet-923	684	34	,	,	PUNCT
admet-923	684	35	c.	c.	PROPN
admet-923	684	36	rotter	rotter	PROPN
admet-923	684	37	,	,	PUNCT
admet-923	684	38	m.	m.	NOUN
admet-923	684	39	varma	varma	PROPN
admet-923	684	40	,	,	PUNCT
admet-923	684	41	m.	m.	PROPN
admet-923	684	42	wong	wong	PROPN
admet-923	684	43	,	,	PUNCT
admet-923	684	44	a.	a.	PROPN
admet-923	684	45	mitra	mitra	PROPN
admet-923	684	46	,	,	PUNCT
admet-923	684	47	j.	j.	PROPN
admet-923	684	48	bevernage	bevernage	PROPN
admet-923	684	49	,	,	PUNCT
admet-923	684	50	j.	j.	PROPN
admet-923	684	51	biewenga	biewenga	PROPN
admet-923	684	52	,	,	PUNCT
admet-923	684	53	a.	a.	PROPN
admet-923	684	54	van	van	PROPN
admet-923	684	55	peer	peer	PROPN
admet-923	684	56	,	,	PUNCT
admet-923	684	57	r.	r.	PROPN
admet-923	684	58	lloyd	lloyd	PROPN
admet-923	684	59	,	,	PUNCT
admet-923	684	60	c.	c.	PROPN
admet-923	684	61	shardlow	shardlow	PROPN
admet-923	684	62	,	,	PUNCT
admet-923	684	63	p.	p.	PROPN
admet-923	684	64	langguth	langguth	PROPN
admet-923	684	65	,	,	PUNCT
admet-923	684	66	i.	i.	PROPN
admet-923	684	67	mishenzon	mishenzon	PROPN
admet-923	684	68	,	,	PUNCT
admet-923	684	69	m.a	m.a	PROPN
admet-923	684	70	.	.	PROPN
admet-923	684	71	nguyen	nguyen	PROPN
admet-923	684	72	,	,	PUNCT
admet-923	684	73	j.	j.	PROPN
admet-923	684	74	brown	brown	PROPN
admet-923	684	75	,	,	PUNCT
admet-923	684	76	h.	h.	PROPN
admet-923	684	77	lennernäs	lennernäs	PROPN
admet-923	684	78	,	,	PUNCT
admet-923	684	79	b.	b.	PROPN
admet-923	684	80	abrahamsson	abrahamsson	PROPN
admet-923	684	81	.	.	PUNCT
admet-923	685	1	imi	imi	PROPN
admet-923	685	2	–	–	PUNCT
admet-923	685	3	oral	oral	ADJ
admet-923	685	4	biopharmaceutics	biopharmaceutics	NOUN
admet-923	685	5	tools	tool	NOUN
admet-923	685	6	project	project	NOUN
admet-923	685	7	–	–	PUNCT
admet-923	685	8	evaluation	evaluation	NOUN
admet-923	685	9	of	of	ADP
admet-923	685	10	bottom	bottom	ADJ
admet-923	685	11	-	-	PUNCT
admet-923	685	12	up	up	ADP
admet-923	685	13	pbpk	pbpk	NOUN
admet-923	685	14	prediction	prediction	NOUN
admet-923	685	15	success	success	NOUN
admet-923	685	16	part	part	NOUN
admet-923	685	17	3	3	NUM
admet-923	685	18	:	:	PUNCT
admet-923	685	19	identifying	identify	VERB
admet-923	685	20	gaps	gap	NOUN
admet-923	685	21	in	in	ADP
admet-923	685	22	system	system	NOUN
admet-923	685	23	parameters	parameter	NOUN
admet-923	685	24	by	by	ADP
admet-923	685	25	analysing	analyse	VERB
admet-923	685	26	in	in	ADP
admet-923	685	27	silico	silico	NOUN
admet-923	685	28	performance	performance	NOUN
admet-923	685	29	across	across	ADP
admet-923	685	30	different	different	ADJ
admet-923	685	31	compound	compound	NOUN
admet-923	685	32	classes	class	NOUN
admet-923	685	33	.	.	PUNCT
admet-923	686	1	eur	eur	PROPN
admet-923	686	2	.	.	PUNCT
admet-923	687	1	j.	j.	PROPN
admet-923	687	2	pharm	pharm	PROPN
admet-923	687	3	.	.	PUNCT
admet-923	688	1	sci	sci	PROPN
admet-923	688	2	.	.	PROPN
admet-923	689	1	96	96	NUM
admet-923	689	2	(	(	PUNCT
admet-923	689	3	2017	2017	NUM
admet-923	689	4	)	)	PUNCT
admet-923	690	1	626–642	626–642	NUM
admet-923	690	2	.	.	PUNCT
admet-923	691	1	[	[	X
admet-923	691	2	3	3	X
admet-923	691	3	]	]	X
admet-923	691	4	e.	e.	PROPN
admet-923	691	5	sjögren	sjögren	PROPN
admet-923	691	6	,	,	PUNCT
admet-923	691	7	h.	h.	PROPN
admet-923	691	8	thörn	thörn	PROPN
admet-923	691	9	,	,	PUNCT
admet-923	691	10	c.	c.	PROPN
admet-923	691	11	tannergren	tannergren	PROPN
admet-923	691	12	.	.	PUNCT
admet-923	692	1	reply	reply	VERB
admet-923	692	2	to	to	ADP
admet-923	692	3	’	'	PUNCT
admet-923	692	4	comment	comment	VERB
admet-923	692	5	on	on	ADP
admet-923	692	6	“	"	PUNCT
admet-923	692	7	in	in	ADP
admet-923	692	8	silico	silico	NOUN
admet-923	692	9	modeling	modeling	NOUN
admet-923	692	10	of	of	ADP
admet-923	692	11	gastrointestinal	gastrointestinal	ADJ
admet-923	692	12	drug	drug	NOUN
admet-923	692	13	absorption	absorption	NOUN
admet-923	692	14	:	:	PUNCT
admet-923	692	15	predictive	predictive	ADJ
admet-923	692	16	performance	performance	NOUN
admet-923	692	17	of	of	ADP
admet-923	692	18	three	three	NUM
admet-923	692	19	physiologically	physiologically	ADV
admet-923	692	20	based	base	VERB
admet-923	692	21	absorption	absorption	NOUN
admet-923	692	22	models	model	NOUN
admet-923	692	23	.	.	PUNCT
admet-923	692	24	”	"	PUNCT
admet-923	693	1	mol	mol	PROPN
admet-923	693	2	.	.	PUNCT
admet-923	693	3	pharm	pharm	PROPN
admet-923	693	4	.	.	PUNCT
admet-923	694	1	14	14	NUM
admet-923	694	2	(	(	PUNCT
admet-923	694	3	2017	2017	NUM
admet-923	694	4	)	)	PUNCT
admet-923	695	1	340–343	340–343	NUM
admet-923	695	2	.	.	PUNCT
admet-923	696	1	[	[	X
admet-923	696	2	4	4	X
admet-923	696	3	]	]	X
admet-923	696	4	e.	e.	PROPN
admet-923	696	5	sjögren	sjögren	PROPN
admet-923	696	6	,	,	PUNCT
admet-923	696	7	h.	h.	PROPN
admet-923	696	8	thorn	thorn	PROPN
admet-923	696	9	,	,	PUNCT
admet-923	696	10	c.	c.	PROPN
admet-923	696	11	tannergren	tannergren	PROPN
admet-923	696	12	.	.	PUNCT
admet-923	697	1	in	in	ADP
admet-923	697	2	silico	silico	NOUN
admet-923	697	3	modeling	modeling	NOUN
admet-923	697	4	of	of	ADP
admet-923	697	5	gastrointestinal	gastrointestinal	ADJ
admet-923	697	6	drug	drug	NOUN
admet-923	697	7	absorption	absorption	NOUN
admet-923	697	8	:	:	PUNCT
admet-923	697	9	predictive	predictive	ADJ
admet-923	697	10	performance	performance	NOUN
admet-923	697	11	of	of	ADP
admet-923	697	12	three	three	NUM
admet-923	697	13	physiologically	physiologically	ADV
admet-923	697	14	based	base	VERB
admet-923	697	15	absorption	absorption	NOUN
admet-923	697	16	models	model	NOUN
admet-923	697	17	.	.	PUNCT
admet-923	698	1	mol	mol	X
admet-923	698	2	.	.	PUNCT
admet-923	698	3	pharm	pharm	PROPN
admet-923	698	4	.	.	PUNCT
admet-923	699	1	13	13	NUM
admet-923	699	2	(	(	PUNCT
admet-923	699	3	2016	2016	NUM
admet-923	699	4	)	)	PUNCT
admet-923	699	5	1763–1778	1763–1778	NUM
admet-923	699	6	.	.	PUNCT
admet-923	700	1	[	[	X
admet-923	700	2	5	5	NUM
admet-923	700	3	]	]	X
admet-923	700	4	n.	n.	NOUN
admet-923	700	5	matsumura	matsumura	PROPN
admet-923	700	6	,	,	PUNCT
admet-923	700	7	s.	s.	PROPN
admet-923	700	8	hayashi	hayashi	PROPN
admet-923	700	9	,	,	PUNCT
admet-923	700	10	y.	y.	PROPN
admet-923	700	11	akiyama	akiyama	PROPN
admet-923	700	12	,	,	PUNCT
admet-923	700	13	a.	a.	PROPN
admet-923	700	14	ono	ono	PROPN
admet-923	700	15	,	,	PUNCT
admet-923	700	16	s.	s.	PROPN
admet-923	700	17	funaki	funaki	PROPN
admet-923	700	18	,	,	PUNCT
admet-923	700	19	n.	n.	PROPN
admet-923	700	20	tamura	tamura	PROPN
admet-923	700	21	,	,	PUNCT
admet-923	700	22	t.	t.	PROPN
admet-923	700	23	kimoto	kimoto	PROPN
admet-923	700	24	,	,	PUNCT
admet-923	700	25	m.	m.	NOUN
admet-923	700	26	jiko	jiko	PROPN
admet-923	700	27	,	,	PUNCT
admet-923	700	28	y.	y.	PROPN
admet-923	700	29	haruna	haruna	PROPN
admet-923	700	30	,	,	PUNCT
admet-923	700	31	a.	a.	PROPN
admet-923	700	32	sarashina	sarashina	PROPN
admet-923	700	33	,	,	PUNCT
admet-923	700	34	others	other	NOUN
admet-923	700	35	.	.	PUNCT
admet-923	701	1	prediction	prediction	NOUN
admet-923	701	2	characteristics	characteristic	NOUN
admet-923	701	3	of	of	ADP
admet-923	701	4	oral	oral	ADJ
admet-923	701	5	absorption	absorption	NOUN
admet-923	701	6	simulation	simulation	NOUN
admet-923	701	7	software	software	NOUN
admet-923	701	8	evaluated	evaluate	VERB
admet-923	701	9	using	use	VERB
admet-923	701	10	structurally	structurally	ADV
admet-923	701	11	diverse	diverse	ADJ
admet-923	701	12	low	low	ADJ
admet-923	701	13	-	-	PUNCT
admet-923	701	14	solubility	solubility	NOUN
admet-923	701	15	drugs	drug	NOUN
admet-923	701	16	.	.	PUNCT
admet-923	702	1	j.	j.	PROPN
admet-923	702	2	pharm	pharm	PROPN
admet-923	702	3	.	.	PUNCT
admet-923	703	1	sci	sci	PROPN
admet-923	703	2	.	.	PROPN
admet-923	704	1	109	109	NUM
admet-923	704	2	(	(	PUNCT
admet-923	704	3	2020	2020	NUM
admet-923	704	4	)	)	PUNCT
admet-923	704	5	1403–1416	1403–1416	NUM
admet-923	704	6	.	.	PUNCT
admet-923	705	1	[	[	X
admet-923	705	2	6	6	NUM
admet-923	705	3	]	]	PUNCT
admet-923	705	4	a.	a.	NOUN
admet-923	705	5	ahmad	ahmad	PROPN
admet-923	705	6	,	,	PUNCT
admet-923	705	7	x.	x.	PROPN
admet-923	705	8	pepin	pepin	PROPN
admet-923	705	9	,	,	PUNCT
admet-923	705	10	l.	l.	PROPN
admet-923	705	11	aarons	aarons	PROPN
admet-923	705	12	,	,	PUNCT
admet-923	705	13	y.	y.	PROPN
admet-923	705	14	wang	wang	PROPN
admet-923	705	15	,	,	PUNCT
admet-923	705	16	a.s	a.s	PROPN
admet-923	705	17	.	.	PROPN
admet-923	705	18	darwich	darwich	PROPN
admet-923	705	19	,	,	PUNCT
admet-923	705	20	j.m	j.m	PROPN
admet-923	705	21	.	.	PROPN
admet-923	705	22	wood	wood	PROPN
admet-923	705	23	,	,	PUNCT
admet-923	705	24	c.	c.	PROPN
admet-923	705	25	tannergren	tannergren	PROPN
admet-923	705	26	,	,	PUNCT
admet-923	705	27	e.	e.	PROPN
admet-923	705	28	karlsson	karlsson	PROPN
admet-923	705	29	,	,	PUNCT
admet-923	705	30	c.	c.	PROPN
admet-923	705	31	patterson	patterson	PROPN
admet-923	705	32	,	,	PUNCT
admet-923	705	33	h.	h.	PROPN
admet-923	705	34	thörn	thörn	PROPN
admet-923	705	35	,	,	PUNCT
admet-923	705	36	others	other	NOUN
admet-923	705	37	.	.	PUNCT
admet-923	706	1	imi	imi	ADJ
admet-923	706	2	--	--	PUNCT
admet-923	706	3	oral	oral	ADJ
admet-923	706	4	biopharmaceutics	biopharmaceutics	NOUN
admet-923	706	5	tools	tool	NOUN
admet-923	706	6	project	project	NOUN
admet-923	706	7	--	--	PUNCT
admet-923	706	8	evaluation	evaluation	NOUN
admet-923	706	9	of	of	ADP
admet-923	706	10	bottom	bottom	ADJ
admet-923	706	11	-	-	PUNCT
admet-923	706	12	up	up	ADP
admet-923	706	13	pbpk	pbpk	NOUN
admet-923	706	14	prediction	prediction	NOUN
admet-923	706	15	success	success	NOUN
admet-923	706	16	part	part	NOUN
admet-923	706	17	4	4	NUM
admet-923	706	18	:	:	PUNCT
admet-923	706	19	prediction	prediction	NOUN
admet-923	706	20	accuracy	accuracy	NOUN
admet-923	706	21	and	and	CCONJ
admet-923	706	22	software	software	NOUN
admet-923	706	23	comparisons	comparison	NOUN
admet-923	706	24	with	with	ADP
admet-923	706	25	improved	improved	ADJ
admet-923	706	26	data	datum	NOUN
admet-923	706	27	and	and	CCONJ
admet-923	706	28	modelling	modelling	NOUN
admet-923	706	29	strategies	strategy	NOUN
admet-923	706	30	.	.	PUNCT
admet-923	707	1	eur	eur	PROPN
admet-923	707	2	.	.	PUNCT
admet-923	708	1	j.	j.	PROPN
admet-923	708	2	pharm	pharm	PROPN
admet-923	708	3	.	.	PUNCT
admet-923	709	1	biopharm	biopharm	PROPN
admet-923	709	2	.	.	PUNCT
admet-923	710	1	(	(	PUNCT
admet-923	710	2	2020	2020	NUM
admet-923	710	3	)	)	PUNCT
admet-923	710	4	.	.	PUNCT
admet-923	711	1	[	[	X
admet-923	711	2	7	7	X
admet-923	711	3	]	]	X
admet-923	711	4	f.l	f.l	PROPN
admet-923	711	5	.	.	PROPN
admet-923	711	6	wood	wood	PROPN
admet-923	711	7	,	,	PUNCT
admet-923	711	8	j.b	j.b	PROPN
admet-923	711	9	.	.	PROPN
admet-923	711	10	houston	houston	PROPN
admet-923	711	11	,	,	PUNCT
admet-923	711	12	d.	d.	PROPN
admet-923	711	13	hallifax	hallifax	PROPN
admet-923	711	14	.	.	PUNCT
admet-923	712	1	clearance	clearance	NOUN
admet-923	712	2	prediction	prediction	NOUN
admet-923	712	3	methodology	methodology	NOUN
admet-923	712	4	needs	need	VERB
admet-923	712	5	fundamental	fundamental	ADJ
admet-923	712	6	improvement	improvement	NOUN
admet-923	712	7	:	:	PUNCT
admet-923	712	8	trends	trend	NOUN
admet-923	712	9	common	common	ADJ
admet-923	712	10	to	to	ADP
admet-923	712	11	rat	rat	NOUN
admet-923	712	12	and	and	CCONJ
admet-923	712	13	human	human	ADJ
admet-923	712	14	hepatocytes	hepatocyte	NOUN
admet-923	712	15	/	/	SYM
admet-923	712	16	microsomes	microsome	NOUN
admet-923	712	17	and	and	CCONJ
admet-923	712	18	implications	implication	NOUN
admet-923	712	19	for	for	ADP
admet-923	712	20	experimental	experimental	ADJ
admet-923	712	21	methodology	methodology	NOUN
admet-923	712	22	.	.	PUNCT
admet-923	713	1	drug	drug	NOUN
admet-923	713	2	metab	metab	PROPN
admet-923	713	3	.	.	PUNCT
admet-923	714	1	dispos	dispos	PROPN
admet-923	714	2	.	.	PUNCT
admet-923	715	1	45	45	NUM
admet-923	715	2	(	(	PUNCT
admet-923	715	3	2017	2017	NUM
admet-923	715	4	)	)	PUNCT
admet-923	715	5	1178–1188	1178–1188	NUM
admet-923	715	6	.	.	PUNCT
admet-923	716	1	[	[	X
admet-923	716	2	8	8	NUM
admet-923	716	3	]	]	X
admet-923	716	4	f.l	f.l	PROPN
admet-923	716	5	.	.	PROPN
admet-923	716	6	wood	wood	PROPN
admet-923	716	7	,	,	PUNCT
admet-923	716	8	j.b	j.b	PROPN
admet-923	716	9	.	.	PROPN
admet-923	716	10	houston	houston	PROPN
admet-923	716	11	,	,	PUNCT
admet-923	716	12	d.	d.	PROPN
admet-923	716	13	hallifax	hallifax	PROPN
admet-923	716	14	.	.	PUNCT
admet-923	717	1	importance	importance	NOUN
admet-923	717	2	of	of	ADP
admet-923	717	3	the	the	DET
admet-923	717	4	unstirred	unstirred	ADJ
admet-923	717	5	water	water	NOUN
admet-923	717	6	layer	layer	NOUN
admet-923	717	7	and	and	CCONJ
admet-923	717	8	hepatocyte	hepatocyte	NOUN
admet-923	717	9	membrane	membrane	NOUN
admet-923	717	10	integrity	integrity	NOUN
admet-923	717	11	in	in	ADP
admet-923	717	12	vitro	vitro	X
admet-923	717	13	for	for	ADP
admet-923	717	14	quantification	quantification	NOUN
admet-923	717	15	of	of	ADP
admet-923	717	16	intrinsic	intrinsic	ADJ
admet-923	717	17	metabolic	metabolic	NOUN
admet-923	717	18	clearance	clearance	NOUN
admet-923	717	19	.	.	PUNCT
admet-923	718	1	drug	drug	NOUN
admet-923	718	2	metab	metab	NOUN
admet-923	718	3	.	.	PUNCT
admet-923	719	1	dispos	dispos	PROPN
admet-923	719	2	.	.	PUNCT
admet-923	720	1	46	46	NUM
admet-923	720	2	(	(	PUNCT
admet-923	720	3	2018	2018	NUM
admet-923	720	4	)	)	PUNCT
admet-923	720	5	268–278	268–278	NUM
admet-923	720	6	.	.	PUNCT
admet-923	721	1	[	[	X
admet-923	721	2	9	9	NUM
admet-923	721	3	]	]	X
admet-923	721	4	d.m	d.m	PROPN
admet-923	721	5	.	.	PROPN
admet-923	721	6	mudie	mudie	PROPN
admet-923	721	7	,	,	PUNCT
admet-923	721	8	n.	n.	PROPN
admet-923	721	9	samiei	samiei	PROPN
admet-923	721	10	,	,	PUNCT
admet-923	721	11	d.j	d.j	PROPN
admet-923	721	12	.	.	PROPN
admet-923	721	13	marshall	marshall	PROPN
admet-923	721	14	,	,	PUNCT
admet-923	721	15	g.e	g.e	PROPN
admet-923	721	16	.	.	PROPN
admet-923	721	17	amidon	amidon	PROPN
admet-923	721	18	,	,	PUNCT
admet-923	721	19	c.a.s	c.a.	VERB
admet-923	721	20	.	.	PROPN
admet-923	721	21	bergström	bergström	NOUN
admet-923	721	22	.	.	PUNCT
admet-923	722	1	selection	selection	NOUN
admet-923	722	2	of	of	ADP
admet-923	722	3	in	in	ADP
admet-923	722	4	vivo	vivo	ADJ
admet-923	722	5	predictive	predictive	ADJ
admet-923	722	6	dissolution	dissolution	NOUN
admet-923	722	7	media	medium	NOUN
admet-923	722	8	using	use	VERB
admet-923	722	9	drug	drug	NOUN
admet-923	722	10	substance	substance	NOUN
admet-923	722	11	and	and	CCONJ
admet-923	722	12	physiological	physiological	ADJ
admet-923	722	13	properties	property	NOUN
admet-923	722	14	.	.	PUNCT
admet-923	723	1	aaps	aap	NOUN
admet-923	723	2	j.	j.	PROPN
admet-923	723	3	22	22	NUM
admet-923	723	4	(	(	PUNCT
admet-923	723	5	2020	2020	NUM
admet-923	723	6	)	)	PUNCT
admet-923	723	7	34	34	NUM
admet-923	723	8	.	.	PUNCT
admet-923	724	1	[	[	X
admet-923	724	2	10	10	NUM
admet-923	724	3	]	]	X
admet-923	724	4	c.	c.	PROPN
admet-923	724	5	kuemmel	kuemmel	PROPN
admet-923	724	6	,	,	PUNCT
admet-923	724	7	y.	y.	PROPN
admet-923	724	8	yang	yang	PROPN
admet-923	724	9	,	,	PUNCT
admet-923	724	10	x.	x.	PROPN
admet-923	724	11	zhang	zhang	PROPN
admet-923	724	12	,	,	PUNCT
admet-923	724	13	j.	j.	PROPN
admet-923	724	14	florian	florian	PROPN
admet-923	724	15	,	,	PUNCT
admet-923	724	16	h.	h.	PROPN
admet-923	724	17	zhu	zhu	PROPN
admet-923	724	18	,	,	PUNCT
admet-923	724	19	m.	m.	NOUN
admet-923	724	20	tegenge	tegenge	PROPN
admet-923	724	21	,	,	PUNCT
admet-923	724	22	s.-m	s.-m	PROPN
admet-923	724	23	.	.	PUNCT
admet-923	725	1	huang	huang	PROPN
admet-923	725	2	,	,	PUNCT
admet-923	725	3	y.	y.	PROPN
admet-923	725	4	wang	wang	PROPN
admet-923	725	5	,	,	PUNCT
admet-923	725	6	t.	t.	PROPN
admet-923	725	7	morrison	morrison	PROPN
admet-923	725	8	,	,	PUNCT
admet-923	725	9	i.	i.	PROPN
admet-923	725	10	zineh	zineh	PROPN
admet-923	725	11	.	.	PUNCT
admet-923	726	1	consideration	consideration	NOUN
admet-923	726	2	of	of	ADP
admet-923	726	3	a	a	DET
admet-923	726	4	credibility	credibility	NOUN
admet-923	726	5	assessment	assessment	NOUN
admet-923	726	6	framework	framework	NOUN
admet-923	726	7	in	in	ADP
admet-923	726	8	model	model	NOUN
admet-923	726	9	-	-	PUNCT
admet-923	726	10	informed	inform	VERB
admet-923	726	11	drug	drug	NOUN
admet-923	726	12	development	development	NOUN
admet-923	726	13	:	:	PUNCT
admet-923	726	14	potential	potential	ADJ
admet-923	726	15	application	application	NOUN
admet-923	726	16	to	to	ADP
admet-923	726	17	physiologically	physiologically	ADV
admet-923	726	18	-	-	PUNCT
admet-923	726	19	based	base	VERB
admet-923	726	20	pharmacokinetic	pharmacokinetic	ADJ
admet-923	726	21	modeling	modeling	NOUN
admet-923	726	22	and	and	CCONJ
admet-923	726	23	simulation	simulation	NOUN
admet-923	726	24	.	.	PUNCT
admet-923	727	1	cpt	cpt	PROPN
admet-923	727	2	pharmacometrics	pharmacometrics	PROPN
admet-923	727	3	syst	syst	PROPN
admet-923	727	4	.	.	PUNCT
admet-923	728	1	pharmacol	pharmacol	PROPN
admet-923	728	2	.	.	PUNCT
admet-923	729	1	9	9	NUM
admet-923	729	2	(	(	PUNCT
admet-923	729	3	2020	2020	NUM
admet-923	729	4	)	)	PUNCT
admet-923	729	5	21–28	21–28	NUM
admet-923	729	6	.	.	PUNCT
admet-923	730	1	[	[	X
admet-923	730	2	11	11	NUM
admet-923	730	3	]	]	PUNCT
admet-923	730	4	m.	m.	NOUN
admet-923	730	5	li	li	PROPN
admet-923	730	6	,	,	PUNCT
admet-923	730	7	p.	p.	PROPN
admet-923	730	8	zhao	zhao	PROPN
admet-923	730	9	,	,	PUNCT
admet-923	730	10	y.	y.	PROPN
admet-923	730	11	pan	pan	PROPN
admet-923	730	12	,	,	PUNCT
admet-923	730	13	c.	c.	PROPN
admet-923	730	14	wagner	wagner	PROPN
admet-923	730	15	.	.	PUNCT
admet-923	731	1	predictive	predictive	ADJ
admet-923	731	2	performance	performance	NOUN
admet-923	731	3	of	of	ADP
admet-923	731	4	physiologically	physiologically	ADV
admet-923	731	5	based	base	VERB
admet-923	731	6	pharmacokinetic	pharmacokinetic	ADJ
admet-923	731	7	models	model	NOUN
admet-923	731	8	for	for	ADP
admet-923	731	9	the	the	DET
admet-923	731	10	effect	effect	NOUN
admet-923	731	11	of	of	ADP
admet-923	731	12	food	food	NOUN
admet-923	731	13	on	on	ADP
admet-923	731	14	oral	oral	ADJ
admet-923	731	15	drug	drug	NOUN
admet-923	731	16	absorption	absorption	NOUN
admet-923	731	17	:	:	PUNCT
admet-923	731	18	current	current	ADJ
admet-923	731	19	status	status	NOUN
admet-923	731	20	.	.	PUNCT
admet-923	732	1	cpt	cpt	PROPN
admet-923	732	2	pharmacometrics	pharmacometrics	PROPN
admet-923	732	3	syst	syst	PROPN
admet-923	732	4	.	.	PUNCT
admet-923	733	1	pharmacol	pharmacol	PROPN
admet-923	733	2	.	.	PROPN
admet-923	734	1	7	7	NUM
admet-923	734	2	(	(	PUNCT
admet-923	734	3	2018	2018	NUM
admet-923	734	4	)	)	PUNCT
admet-923	735	1	82–89	82–89	NUM
admet-923	735	2	.	.	PUNCT
admet-923	736	1	[	[	X
admet-923	736	2	12	12	NUM
admet-923	736	3	]	]	PUNCT
admet-923	736	4	m.	m.	NOUN
admet-923	736	5	shebley	shebley	PROPN
admet-923	736	6	,	,	PUNCT
admet-923	736	7	p.	p.	PROPN
admet-923	736	8	sandhu	sandhu	PROPN
admet-923	736	9	,	,	PUNCT
admet-923	736	10	a.	a.	PROPN
admet-923	736	11	emami	emami	PROPN
admet-923	736	12	riedmaier	riedmaier	PROPN
admet-923	736	13	,	,	PUNCT
admet-923	736	14	m.	m.	PROPN
admet-923	736	15	jamei	jamei	PROPN
admet-923	736	16	,	,	PUNCT
admet-923	736	17	r.	r.	PROPN
admet-923	736	18	narayanan	narayanan	PROPN
admet-923	736	19	,	,	PUNCT
admet-923	736	20	a.	a.	PROPN
admet-923	736	21	patel	patel	PROPN
admet-923	736	22	,	,	PUNCT
admet-923	736	23	s.a	s.a	PROPN
admet-923	736	24	.	.	PROPN
admet-923	736	25	peters	peters	PROPN
admet-923	736	26	,	,	PUNCT
admet-923	736	27	v.p	v.p	PROPN
admet-923	736	28	.	.	PROPN
admet-923	736	29	reddy	reddy	PROPN
admet-923	736	30	,	,	PUNCT
admet-923	736	31	m.	m.	PROPN
admet-923	736	32	zheng	zheng	PROPN
admet-923	736	33	,	,	PUNCT
admet-923	736	34	l.	l.	PROPN
admet-923	736	35	de	de	PROPN
admet-923	736	36	zwart	zwart	PROPN
admet-923	736	37	,	,	PUNCT
admet-923	736	38	m.	m.	NOUN
admet-923	736	39	beneton	beneton	NOUN
admet-923	736	40	,	,	PUNCT
admet-923	736	41	f.	f.	PROPN
admet-923	736	42	bouzom	bouzom	PROPN
admet-923	736	43	,	,	PUNCT
admet-923	736	44	j.	j.	PROPN
admet-923	736	45	chen	chen	PROPN
admet-923	736	46	,	,	PUNCT
admet-923	736	47	y.	y.	PROPN
admet-923	736	48	chen	chen	PROPN
admet-923	736	49	,	,	PUNCT
admet-923	736	50	y.	y.	PROPN
admet-923	736	51	cleary	cleary	PROPN
admet-923	736	52	,	,	PUNCT
admet-923	736	53	c.	c.	PROPN
admet-923	736	54	collins	collins	PROPN
admet-923	736	55	,	,	PUNCT
admet-923	736	56	g.l	g.l	PROPN
admet-923	736	57	.	.	PROPN
admet-923	736	58	dickinson	dickinson	PROPN
admet-923	736	59	,	,	PUNCT
admet-923	736	60	n.	n.	NOUN
admet-923	736	61	djebli	djebli	PROPN
admet-923	736	62	,	,	PUNCT
admet-923	736	63	h.j	h.j	PROPN
admet-923	736	64	.	.	PROPN
admet-923	736	65	einolf	einolf	PROPN
admet-923	736	66	,	,	PUNCT
admet-923	736	67	i.	i.	PROPN
admet-923	736	68	gardner	gardner	PROPN
admet-923	736	69	,	,	PUNCT
admet-923	736	70	f.	f.	PROPN
admet-923	736	71	huth	huth	PROPN
admet-923	736	72	,	,	PUNCT
admet-923	736	73	f.	f.	PROPN
admet-923	736	74	kazmi	kazmi	PROPN
admet-923	736	75	,	,	PUNCT
admet-923	736	76	f.	f.	PROPN
admet-923	736	77	khalil	khalil	PROPN
admet-923	736	78	,	,	PUNCT
admet-923	736	79	j.	j.	PROPN
admet-923	736	80	lin	lin	PROPN
admet-923	736	81	,	,	PUNCT
admet-923	736	82	a.	a.	NOUN
admet-923	736	83	odinecs	odinecs	NOUN
admet-923	736	84	,	,	PUNCT
admet-923	736	85	c.	c.	PROPN
admet-923	736	86	patel	patel	PROPN
admet-923	736	87	,	,	PUNCT
admet-923	736	88	h.	h.	PROPN
admet-923	736	89	rong	rong	PROPN
admet-923	736	90	,	,	PUNCT
admet-923	736	91	e.	e.	PROPN
admet-923	736	92	schuck	schuck	PROPN
admet-923	736	93	,	,	PUNCT
admet-923	736	94	p.	p.	PROPN
admet-923	736	95	sharma	sharma	PROPN
admet-923	736	96	,	,	PUNCT
admet-923	736	97	s.p	s.p	PROPN
admet-923	736	98	.	.	PROPN
admet-923	736	99	wu	wu	PROPN
admet-923	736	100	,	,	PUNCT
admet-923	736	101	y.	y.	PROPN
admet-923	736	102	xu	xu	PROPN
admet-923	736	103	,	,	PUNCT
admet-923	736	104	s.	s.	PROPN
admet-923	736	105	yamazaki	yamazaki	PROPN
admet-923	736	106	,	,	PUNCT
admet-923	736	107	k.	k.	PROPN
admet-923	736	108	yoshida	yoshida	PROPN
admet-923	736	109	,	,	PUNCT
admet-923	736	110	m.	m.	NOUN
admet-923	736	111	rowland	rowland	PROPN
admet-923	736	112	.	.	PUNCT
admet-923	737	1	physiologically	physiologically	ADV
admet-923	737	2	based	base	VERB
admet-923	737	3	pharmacokinetic	pharmacokinetic	ADJ
admet-923	737	4	model	model	NOUN
admet-923	737	5	qualification	qualification	NOUN
admet-923	737	6	and	and	CCONJ
admet-923	737	7	reporting	reporting	NOUN
admet-923	737	8	procedures	procedure	NOUN
admet-923	737	9	for	for	ADP
admet-923	737	10	regulatory	regulatory	ADJ
admet-923	737	11	submissions	submission	NOUN
admet-923	737	12	:	:	PUNCT
admet-923	737	13	a	a	DET
admet-923	737	14	consortium	consortium	NOUN
admet-923	737	15	perspective	perspective	NOUN
admet-923	737	16	.	.	PUNCT
admet-923	738	1	clin	clin	PROPN
admet-923	738	2	.	.	PUNCT
admet-923	739	1	pharmacol	pharmacol	PROPN
admet-923	739	2	.	.	PUNCT
admet-923	740	1	ther	ther	PROPN
admet-923	740	2	.	.	PUNCT
admet-923	741	1	104	104	NUM
admet-923	741	2	(	(	PUNCT
admet-923	741	3	2018	2018	NUM
admet-923	741	4	)	)	PUNCT
admet-923	741	5	88–110	88–110	NOUN
admet-923	741	6	.	.	PUNCT
admet-923	742	1	[	[	X
admet-923	742	2	13	13	NUM
admet-923	742	3	]	]	X
admet-923	742	4	u.s.f	u.s.f	PROPN
admet-923	742	5	.	.	PROPN
admet-923	742	6	and	and	CCONJ
admet-923	742	7	d.	d.	PROPN
admet-923	742	8	administration	administration	PROPN
admet-923	742	9	.	.	PUNCT
admet-923	743	1	physiologically	physiologically	ADV
admet-923	743	2	based	base	VERB
admet-923	743	3	pharmacokinetic	pharmacokinetic	ADJ
admet-923	743	4	analyses	analysis	NOUN
admet-923	743	5	—	—	PUNCT
admet-923	743	6	format	format	NOUN
admet-923	743	7	and	and	CCONJ
admet-923	743	8	content	content	NOUN
admet-923	743	9	.	.	PUNCT
admet-923	744	1	guidance	guidance	NOUN
admet-923	744	2	.	.	PUNCT
admet-923	745	1	(	(	PUNCT
admet-923	745	2	2018	2018	NUM
admet-923	745	3	)	)	PUNCT
admet-923	745	4	.	.	PUNCT
admet-923	746	1	[	[	X
admet-923	746	2	14	14	NUM
admet-923	746	3	]	]	PUNCT
admet-923	746	4	j.	j.	PROPN
admet-923	746	5	dibella	dibella	PROPN
admet-923	746	6	,	,	PUNCT
admet-923	746	7	j.e	j.e	PROPN
admet-923	746	8	.	.	PROPN
admet-923	746	9	sager	sager	PROPN
admet-923	746	10	,	,	PUNCT
admet-923	746	11	j.	j.	PROPN
admet-923	746	12	yu	yu	PROPN
admet-923	746	13	,	,	PUNCT
admet-923	746	14	i.	i.	PROPN
admet-923	746	15	ragueneau	ragueneau	PROPN
admet-923	746	16	-	-	PUNCT
admet-923	746	17	majlessi	majlessi	ADJ
admet-923	746	18	,	,	PUNCT
admet-923	746	19	n.	n.	NOUN
admet-923	746	20	isoherranen	isoherranen	PROPN
admet-923	746	21	,	,	PUNCT
admet-923	746	22	x.	x.	PROPN
admet-923	746	23	zhuang	zhuang	PROPN
admet-923	746	24	,	,	PUNCT
admet-923	746	25	c.	c.	PROPN
admet-923	746	26	lu	lu	PROPN
admet-923	746	27	,	,	PUNCT
admet-923	746	28	a.b	a.b	PROPN
admet-923	746	29	.	.	PROPN
admet-923	746	30	pharmaceutica	pharmaceutica	PROPN
admet-923	746	31	sinica	sinica	PROPN
admet-923	746	32	,	,	PUNCT
admet-923	746	33	european	european	PROPN
admet-923	746	34	medicines	medicines	PROPN
admet-923	746	35	agency	agency	PROPN
admet-923	746	36	committee	committee	PROPN
admet-923	746	37	for	for	ADP
admet-923	746	38	medicinal	medicinal	ADJ
admet-923	746	39	products	product	NOUN
admet-923	746	40	for	for	ADP
admet-923	746	41	human	human	ADJ
admet-923	746	42	use	use	NOUN
admet-923	746	43	,	,	PUNCT
admet-923	746	44	a.	a.	NOUN
admet-923	746	45	nordmark	nordmark	PROPN
admet-923	746	46	,	,	PUNCT
admet-923	746	47	u.s	u.s	PROPN
admet-923	746	48	.	.	PROPN
admet-923	746	49	department	department	PROPN
admet-923	746	50	of	of	ADP
admet-923	746	51	health	health	PROPN
admet-923	746	52	and	and	CCONJ
admet-923	746	53	human	human	PROPN
admet-923	746	54	services	service	NOUN
admet-923	746	55	food	food	NOUN
admet-923	746	56	and	and	CCONJ
admet-923	746	57	drug	drug	PROPN
admet-923	746	58	administration	administration	NOUN
admet-923	746	59	cder	cder	NOUN
admet-923	746	60	,	,	PUNCT
admet-923	746	61	e.	e.	PROPN
admet-923	746	62	medicines	medicines	PROPN
admet-923	746	63	agency	agency	NOUN
admet-923	746	64	.	.	PUNCT
admet-923	747	1	guideline	guideline	NOUN
admet-923	747	2	on	on	ADP
admet-923	747	3	the	the	DET
admet-923	747	4	qualification	qualification	NOUN
admet-923	747	5	and	and	CCONJ
admet-923	747	6	reporting	reporting	NOUN
admet-923	747	7	of	of	ADP
admet-923	747	8	physiologically	physiologically	ADV
admet-923	747	9	based	base	VERB
admet-923	747	10	pharmacokinetic	pharmacokinetic	ADJ
admet-923	747	11	(	(	PUNCT
admet-923	747	12	pbpk	pbpk	NOUN
admet-923	747	13	)	)	PUNCT
admet-923	747	14	modelling	modelling	NOUN
admet-923	747	15	and	and	CCONJ
admet-923	747	16	simulation	simulation	NOUN
admet-923	747	17	.	.	PUNCT
admet-923	748	1	acta	acta	PROPN
admet-923	748	2	pharm	pharm	PROPN
admet-923	748	3	.	.	PUNCT
admet-923	749	1	sin	sin	PROPN
admet-923	749	2	.	.	PUNCT
admet-923	750	1	b.	b.	PROPN
admet-923	750	2	44	44	NUM
admet-923	750	3	(	(	PUNCT
admet-923	750	4	2016	2016	NUM
admet-923	750	5	)	)	PUNCT
admet-923	750	6	27–29	27–29	NUM
admet-923	750	7	.	.	PUNCT
admet-923	751	1	http://www.ema.europa.eu/docs/en_gb/document_library/scientific_guideline/2016/07/wc50021	http://www.ema.europa.eu/docs/en_gb/document_library/scientific_guideline/2016/07/wc50021	PROPN
admet-923	751	2	1315.pdf%0awww.elsevier.com	1315.pdf%0awww.elsevier.com	NUM
admet-923	751	3	/	/	SYM
admet-923	751	4	locate	locate	ADJ
admet-923	751	5	/	/	SYM
admet-923	751	6	apsb%0awww.sciencedirect.com%0ahttp://dx.doi.org/10.10	apsb%0awww.sciencedirect.com%0ahttp://dx.doi.org/10.10	PRON
admet-923	751	7	16	16	NUM
admet-923	751	8	/	/	SYM
admet-923	751	9	j.apsb.2016.04.004	j.apsb.2016.04.004	NOUN
admet-923	751	10	.	.	PUNCT
admet-923	752	1	[	[	X
admet-923	752	2	15	15	NUM
admet-923	752	3	]	]	X
admet-923	752	4	d.l	d.l	PROPN
admet-923	752	5	.	.	PROPN
admet-923	752	6	sackett	sackett	PROPN
admet-923	752	7	,	,	PUNCT
admet-923	752	8	w.m.c	w.m.c	PROPN
admet-923	752	9	.	.	PUNCT
admet-923	753	1	rosenberg	rosenberg	PROPN
admet-923	753	2	,	,	PUNCT
admet-923	753	3	j.a.m	j.a.m	PROPN
admet-923	753	4	.	.	PUNCT
admet-923	753	5	gray	gray	ADJ
admet-923	753	6	,	,	PUNCT
admet-923	753	7	r.b	r.b	PROPN
admet-923	753	8	.	.	PROPN
admet-923	753	9	haynes	haynes	PROPN
admet-923	753	10	,	,	PUNCT
admet-923	753	11	w.s	w.s	PROPN
admet-923	753	12	.	.	PROPN
admet-923	753	13	richardson	richardson	PROPN
admet-923	753	14	.	.	PUNCT
admet-923	754	1	evidence	evidence	NOUN
admet-923	754	2	based	base	VERB
admet-923	754	3	medicine	medicine	NOUN
admet-923	754	4	:	:	PUNCT
admet-923	754	5	what	what	PRON
admet-923	754	6	it	it	PRON
admet-923	754	7	is	be	AUX
admet-923	754	8	and	and	CCONJ
admet-923	754	9	what	what	PRON
admet-923	754	10	it	it	PRON
admet-923	754	11	is	be	AUX
admet-923	754	12	n’t	n’t	ADJ
admet-923	754	13	.	.	PUNCT
admet-923	755	1	(	(	PUNCT
admet-923	755	2	1996	1996	NUM
admet-923	755	3	)	)	PUNCT
admet-923	755	4	.	.	PUNCT
admet-923	756	1	https://doi.org/10.5599/admet.923	https://doi.org/10.5599/admet.923	X
admet-923	756	2	http://www.ema.europa.eu/docs/en_gb/document_library/scientific_guideline/2016/07/wc500211315.pdf%0awww.elsevier.com/locate/apsb%0awww.sciencedirect.com%0ahttp:/dx.doi.org/10.1016/j.apsb.2016.04.004	http://www.ema.europa.eu/docs/en_gb/document_library/scientific_guideline/2016/07/wc500211315.pdf%0awww.elsevier.com/locate/apsb%0awww.sciencedirect.com%0ahttp:/dx.doi.org/10.1016/j.apsb.2016.04.004	X
admet-923	756	3	http://www.ema.europa.eu/docs/en_gb/document_library/scientific_guideline/2016/07/wc500211315.pdf%0awww.elsevier.com/locate/apsb%0awww.sciencedirect.com%0ahttp:/dx.doi.org/10.1016/j.apsb.2016.04.004	http://www.ema.europa.eu/docs/en_gb/document_library/scientific_guideline/2016/07/wc500211315.pdf%0awww.elsevier.com/locate/apsb%0awww.sciencedirect.com%0ahttp:/dx.doi.org/10.1016/j.apsb.2016.04.004	X
admet-923	756	4	http://www.ema.europa.eu/docs/en_gb/document_library/scientific_guideline/2016/07/wc500211315.pdf%0awww.elsevier.com/locate/apsb%0awww.sciencedirect.com%0ahttp:/dx.doi.org/10.1016/j.apsb.2016.04.004	http://www.ema.europa.eu/docs/en_gb/document_library/scientific_guideline/2016/07/wc500211315.pdf%0awww.elsevier.com/locate/apsb%0awww.sciencedirect.com%0ahttp:/dx.doi.org/10.1016/j.apsb.2016.04.004	NOUN
admet-923	756	5	kiyohiko	kiyohiko	NOUN
admet-923	756	6	sugano	sugano	PROPN
admet-923	756	7	admet	admet	PROPN
admet-923	756	8	&	&	CCONJ
admet-923	756	9	dmpk	dmpk	PROPN
admet-923	756	10	9(2	9(2	NUM
admet-923	756	11	)	)	PUNCT
admet-923	756	12	(	(	PUNCT
admet-923	756	13	2021	2021	NUM
admet-923	756	14	)	)	PUNCT
admet-923	756	15	75	75	NUM
admet-923	756	16	-	-	SYM
admet-923	756	17	109	109	NUM
admet-923	756	18	100	100	NUM
admet-923	756	19	[	[	X
admet-923	756	20	16	16	NUM
admet-923	756	21	]	]	PUNCT
admet-923	756	22	i.	i.	NOUN
admet-923	756	23	masic	masic	PROPN
admet-923	756	24	,	,	PUNCT
admet-923	756	25	m.	m.	NOUN
admet-923	756	26	miokovic	miokovic	PROPN
admet-923	756	27	,	,	PUNCT
admet-923	756	28	b.	b.	PROPN
admet-923	756	29	muhamedagic	muhamedagic	PROPN
admet-923	756	30	.	.	PUNCT
admet-923	757	1	evidence	evidence	NOUN
admet-923	757	2	based	base	VERB
admet-923	757	3	medicine	medicine	NOUN
admet-923	757	4	--	--	PUNCT
admet-923	757	5	new	new	ADJ
admet-923	757	6	approaches	approach	NOUN
admet-923	757	7	and	and	CCONJ
admet-923	757	8	challenges	challenge	NOUN
admet-923	757	9	.	.	PUNCT
admet-923	758	1	acta	acta	PROPN
admet-923	758	2	inform	inform	NOUN
admet-923	758	3	.	.	PUNCT
admet-923	759	1	medica	medica	PROPN
admet-923	759	2	.	.	PUNCT
admet-923	760	1	16	16	NUM
admet-923	760	2	(	(	PUNCT
admet-923	760	3	2008	2008	NUM
admet-923	760	4	)	)	PUNCT
admet-923	760	5	219	219	NUM
admet-923	760	6	.	.	PUNCT
admet-923	761	1	[	[	X
admet-923	761	2	17	17	NUM
admet-923	761	3	]	]	PUNCT
admet-923	761	4	m.	m.	NOUN
admet-923	761	5	li	li	PROPN
admet-923	761	6	,	,	PUNCT
admet-923	761	7	p.	p.	PROPN
admet-923	761	8	zhao	zhao	PROPN
admet-923	761	9	,	,	PUNCT
admet-923	761	10	y.	y.	PROPN
admet-923	761	11	pan	pan	PROPN
admet-923	761	12	,	,	PUNCT
admet-923	761	13	c.	c.	PROPN
admet-923	761	14	wagner	wagner	PROPN
admet-923	761	15	.	.	PUNCT
admet-923	762	1	predictive	predictive	ADJ
admet-923	762	2	performance	performance	NOUN
admet-923	762	3	of	of	ADP
admet-923	762	4	physiologically	physiologically	ADV
admet-923	762	5	based	base	VERB
admet-923	762	6	pharmacokinetic	pharmacokinetic	ADJ
admet-923	762	7	models	model	NOUN
admet-923	762	8	for	for	ADP
admet-923	762	9	the	the	DET
admet-923	762	10	effect	effect	NOUN
admet-923	762	11	of	of	ADP
admet-923	762	12	food	food	NOUN
admet-923	762	13	on	on	ADP
admet-923	762	14	oral	oral	ADJ
admet-923	762	15	drug	drug	NOUN
admet-923	762	16	absorption	absorption	NOUN
admet-923	762	17	:	:	PUNCT
admet-923	762	18	current	current	ADJ
admet-923	762	19	status	status	NOUN
admet-923	762	20	.	.	PUNCT
admet-923	763	1	cpt	cpt	PROPN
admet-923	763	2	pharmacometrics	pharmacometrics	PROPN
admet-923	763	3	syst	syst	PROPN
admet-923	763	4	.	.	PUNCT
admet-923	764	1	pharmacol	pharmacol	PROPN
admet-923	764	2	.	.	PROPN
admet-923	765	1	7	7	NUM
admet-923	765	2	(	(	PUNCT
admet-923	765	3	2018	2018	NUM
admet-923	765	4	)	)	PUNCT
admet-923	766	1	82–89	82–89	NUM
admet-923	766	2	.	.	PUNCT
admet-923	767	1	[	[	X
admet-923	767	2	18	18	NUM
admet-923	767	3	]	]	PUNCT
admet-923	767	4	k.	k.	PROPN
admet-923	767	5	jaqaman	jaqaman	PROPN
admet-923	767	6	,	,	PUNCT
admet-923	767	7	g.	g.	PROPN
admet-923	767	8	danuser	danuser	PROPN
admet-923	767	9	.	.	PUNCT
admet-923	768	1	linking	link	VERB
admet-923	768	2	data	datum	NOUN
admet-923	768	3	to	to	ADP
admet-923	768	4	models	model	NOUN
admet-923	768	5	:	:	PUNCT
admet-923	768	6	data	datum	NOUN
admet-923	768	7	regression	regression	NOUN
admet-923	768	8	.	.	PUNCT
admet-923	769	1	nat	nat	PROPN
admet-923	769	2	.	.	PUNCT
admet-923	770	1	rev	rev	PROPN
admet-923	770	2	.	.	PROPN
admet-923	770	3	mol	mol	PROPN
admet-923	770	4	.	.	PROPN
admet-923	770	5	cell	cell	PROPN
admet-923	770	6	biol	biol	PROPN
admet-923	770	7	.	.	PUNCT
admet-923	771	1	7	7	NUM
admet-923	771	2	(	(	PUNCT
admet-923	771	3	2006	2006	NUM
admet-923	771	4	)	)	PUNCT
admet-923	771	5	813–819	813–819	NUM
admet-923	771	6	.	.	PUNCT
admet-923	772	1	[	[	X
admet-923	772	2	19	19	NUM
admet-923	772	3	]	]	X
admet-923	772	4	w.	w.	NOUN
admet-923	772	5	slob	slob	PROPN
admet-923	772	6	,	,	PUNCT
admet-923	772	7	p.h.m	p.h.m	NOUN
admet-923	772	8	.	.	PUNCT
admet-923	773	1	janssen	janssen	PROPN
admet-923	773	2	,	,	PUNCT
admet-923	773	3	j.m	j.m	PROPN
admet-923	773	4	.	.	PROPN
admet-923	773	5	den	den	PROPN
admet-923	773	6	hof	hof	PROPN
admet-923	773	7	.	.	PUNCT
admet-923	774	1	structural	structural	ADJ
admet-923	774	2	identifiability	identifiability	NOUN
admet-923	774	3	of	of	ADP
admet-923	774	4	pbpk	pbpk	ADJ
admet-923	774	5	models	model	NOUN
admet-923	774	6	:	:	PUNCT
admet-923	774	7	practical	practical	ADJ
admet-923	774	8	consequences	consequence	NOUN
admet-923	774	9	for	for	ADP
admet-923	774	10	modeling	model	VERB
admet-923	774	11	strategies	strategy	NOUN
admet-923	774	12	and	and	CCONJ
admet-923	774	13	study	study	NOUN
admet-923	774	14	designs	design	NOUN
admet-923	774	15	.	.	PUNCT
admet-923	775	1	crit	crit	PROPN
admet-923	775	2	.	.	PUNCT
admet-923	776	1	rev	rev	PROPN
admet-923	776	2	.	.	PROPN
admet-923	777	1	toxicol	toxicol	PROPN
admet-923	777	2	.	.	PUNCT
admet-923	778	1	27	27	NUM
admet-923	778	2	(	(	PUNCT
admet-923	778	3	1997	1997	NUM
admet-923	778	4	)	)	PUNCT
admet-923	779	1	261–272	261–272	NUM
admet-923	779	2	.	.	PUNCT
admet-923	780	1	[	[	X
admet-923	780	2	20	20	NUM
admet-923	780	3	]	]	X
admet-923	780	4	s.a	s.a	PROPN
admet-923	780	5	.	.	PROPN
admet-923	780	6	peters	peters	PROPN
admet-923	780	7	,	,	PUNCT
admet-923	780	8	h.	h.	PROPN
admet-923	780	9	dolgos	dolgos	PROPN
admet-923	780	10	.	.	PUNCT
admet-923	781	1	requirements	requirement	NOUN
admet-923	781	2	to	to	ADP
admet-923	781	3	establishing	establish	VERB
admet-923	781	4	confidence	confidence	NOUN
admet-923	781	5	in	in	ADP
admet-923	781	6	physiologically	physiologically	ADV
admet-923	781	7	based	base	VERB
admet-923	781	8	pharmacokinetic	pharmacokinetic	ADJ
admet-923	781	9	(	(	PUNCT
admet-923	781	10	pbpk	pbpk	NOUN
admet-923	781	11	)	)	PUNCT
admet-923	781	12	models	model	NOUN
admet-923	781	13	and	and	CCONJ
admet-923	781	14	overcoming	overcome	VERB
admet-923	781	15	some	some	PRON
admet-923	781	16	of	of	ADP
admet-923	781	17	the	the	DET
admet-923	781	18	challenges	challenge	NOUN
admet-923	781	19	to	to	PART
admet-923	781	20	meeting	meet	VERB
admet-923	781	21	them	they	PRON
admet-923	781	22	.	.	PUNCT
admet-923	782	1	clin	clin	PROPN
admet-923	782	2	.	.	PUNCT
admet-923	782	3	pharmacokinet	pharmacokinet	PROPN
admet-923	782	4	.	.	PUNCT
admet-923	783	1	58	58	NUM
admet-923	783	2	(	(	PUNCT
admet-923	783	3	2019	2019	NUM
admet-923	783	4	)	)	PUNCT
admet-923	783	5	1355–1371	1355–1371	NUM
admet-923	783	6	.	.	PUNCT
admet-923	784	1	[	[	X
admet-923	784	2	21	21	NUM
admet-923	784	3	]	]	X
admet-923	784	4	n.	n.	PROPN
admet-923	784	5	tsamandouras	tsamandouras	PROPN
admet-923	784	6	,	,	PUNCT
admet-923	784	7	a.	a.	PROPN
admet-923	784	8	rostami	rostami	PROPN
admet-923	784	9	-	-	PUNCT
admet-923	784	10	hodjegan	hodjegan	PROPN
admet-923	784	11	,	,	PUNCT
admet-923	784	12	l.	l.	PROPN
admet-923	784	13	aarons	aarons	PROPN
admet-923	784	14	.	.	PUNCT
admet-923	785	1	combining	combine	VERB
admet-923	785	2	the	the	DET
admet-923	785	3	“	"	PUNCT
admet-923	785	4	bottom	bottom	NOUN
admet-923	785	5	up	up	ADP
admet-923	785	6	”	"	PUNCT
admet-923	785	7	and	and	CCONJ
admet-923	785	8	“	"	PUNCT
admet-923	785	9	top	top	VERB
admet-923	785	10	down	down	ADP
admet-923	785	11	”	"	PUNCT
admet-923	785	12	approaches	approach	NOUN
admet-923	785	13	in	in	ADP
admet-923	785	14	pharmacokinetic	pharmacokinetic	ADJ
admet-923	785	15	modelling	modelling	NOUN
admet-923	785	16	:	:	PUNCT
admet-923	785	17	fitting	fitting	ADJ
admet-923	785	18	pbpk	pbpk	ADJ
admet-923	785	19	models	model	NOUN
admet-923	785	20	to	to	PART
admet-923	785	21	observed	observe	VERB
admet-923	785	22	clinical	clinical	ADJ
admet-923	785	23	data	datum	NOUN
admet-923	785	24	.	.	PUNCT
admet-923	786	1	br	br	PROPN
admet-923	786	2	.	.	PUNCT
admet-923	787	1	j.	j.	PROPN
admet-923	787	2	clin	clin	PROPN
admet-923	787	3	.	.	PUNCT
admet-923	788	1	pharmacol	pharmacol	PROPN
admet-923	788	2	.	.	PUNCT
admet-923	789	1	79	79	NUM
admet-923	789	2	(	(	PUNCT
admet-923	789	3	2015	2015	NUM
admet-923	789	4	)	)	PUNCT
admet-923	790	1	48–55	48–55	NUM
admet-923	790	2	.	.	PUNCT
admet-923	791	1	[	[	X
admet-923	791	2	22	22	NUM
admet-923	791	3	]	]	X
admet-923	791	4	j.w.t	j.w.t	NOUN
admet-923	791	5	.	.	PUNCT
admet-923	792	1	yates	yates	PROPN
admet-923	792	2	.	.	PUNCT
admet-923	793	1	structural	structural	ADJ
admet-923	793	2	identifiability	identifiability	NOUN
admet-923	793	3	of	of	ADP
admet-923	793	4	physiologically	physiologically	ADV
admet-923	793	5	based	base	VERB
admet-923	793	6	pharmacokinetic	pharmacokinetic	ADJ
admet-923	793	7	models	model	NOUN
admet-923	793	8	.	.	PUNCT
admet-923	794	1	j.	j.	PROPN
admet-923	794	2	pharmacokinet	pharmacokinet	PROPN
admet-923	794	3	.	.	PUNCT
admet-923	795	1	pharmacodyn	pharmacodyn	ADV
admet-923	795	2	.	.	PUNCT
admet-923	796	1	33	33	NUM
admet-923	796	2	(	(	PUNCT
admet-923	796	3	2006	2006	NUM
admet-923	796	4	)	)	PUNCT
admet-923	796	5	421–439	421–439	NUM
admet-923	796	6	.	.	PUNCT
admet-923	797	1	[	[	X
admet-923	797	2	23	23	NUM
admet-923	797	3	]	]	X
admet-923	797	4	r.	r.	PROPN
admet-923	797	5	muñoz	muñoz	PROPN
admet-923	797	6	-	-	PUNCT
admet-923	797	7	tamayo	tamayo	PROPN
admet-923	797	8	,	,	PUNCT
admet-923	797	9	l.	l.	PROPN
admet-923	797	10	puillet	puillet	PROPN
admet-923	797	11	,	,	PUNCT
admet-923	797	12	j.-b	j.-b	PROPN
admet-923	797	13	.	.	PUNCT
admet-923	798	1	daniel	daniel	PROPN
admet-923	798	2	,	,	PUNCT
admet-923	798	3	d.	d.	PROPN
admet-923	798	4	sauvant	sauvant	PROPN
admet-923	798	5	,	,	PUNCT
admet-923	798	6	o.	o.	PROPN
admet-923	798	7	martin	martin	PROPN
admet-923	798	8	,	,	PUNCT
admet-923	798	9	m.	m.	NOUN
admet-923	798	10	taghipoor	taghipoor	PROPN
admet-923	798	11	,	,	PUNCT
admet-923	798	12	p.	p.	PROPN
admet-923	798	13	blavy	blavy	PROPN
admet-923	798	14	.	.	PUNCT
admet-923	799	1	to	to	PART
admet-923	799	2	be	be	AUX
admet-923	799	3	or	or	CCONJ
admet-923	799	4	not	not	PART
admet-923	799	5	to	to	PART
admet-923	799	6	be	be	AUX
admet-923	799	7	an	an	DET
admet-923	799	8	identifiable	identifiable	ADJ
admet-923	799	9	model	model	NOUN
admet-923	799	10	.	.	PUNCT
admet-923	800	1	is	be	AUX
admet-923	800	2	this	this	PRON
admet-923	800	3	a	a	DET
admet-923	800	4	relevant	relevant	ADJ
admet-923	800	5	question	question	NOUN
admet-923	800	6	in	in	ADP
admet-923	800	7	animal	animal	NOUN
admet-923	800	8	science	science	NOUN
admet-923	800	9	modelling	modelling	NOUN
admet-923	800	10	?	?	PUNCT
admet-923	801	1	animal	animal	NOUN
admet-923	801	2	.	.	PUNCT
admet-923	802	1	12	12	NUM
admet-923	802	2	(	(	PUNCT
admet-923	802	3	2018	2018	NUM
admet-923	802	4	)	)	PUNCT
admet-923	803	1	701–712	701–712	NUM
admet-923	803	2	.	.	PUNCT
admet-923	804	1	[	[	X
admet-923	804	2	24	24	NUM
admet-923	804	3	]	]	PUNCT
admet-923	804	4	r.	r.	PROPN
admet-923	804	5	bellman	bellman	PROPN
admet-923	804	6	,	,	PUNCT
admet-923	804	7	k.j	k.j	PROPN
admet-923	804	8	.	.	PROPN
admet-923	804	9	åström	åström	NOUN
admet-923	804	10	.	.	PUNCT
admet-923	805	1	on	on	ADP
admet-923	805	2	structural	structural	ADJ
admet-923	805	3	identifiability	identifiability	NOUN
admet-923	805	4	.	.	PUNCT
admet-923	806	1	math	math	NOUN
admet-923	806	2	.	.	PUNCT
admet-923	807	1	biosci	biosci	PROPN
admet-923	807	2	.	.	PUNCT
admet-923	808	1	7	7	NUM
admet-923	808	2	(	(	PUNCT
admet-923	808	3	1970	1970	NUM
admet-923	808	4	)	)	PUNCT
admet-923	808	5	329–339	329–339	NUM
admet-923	808	6	.	.	PUNCT
admet-923	809	1	[	[	X
admet-923	809	2	25	25	NUM
admet-923	809	3	]	]	SYM
admet-923	809	4	d.b	d.b	PROPN
admet-923	809	5	.	.	PROPN
admet-923	809	6	turner	turner	PROPN
admet-923	809	7	,	,	PUNCT
admet-923	809	8	b.	b.	PROPN
admet-923	809	9	liu	liu	PROPN
admet-923	809	10	,	,	PUNCT
admet-923	809	11	n.	n.	PROPN
admet-923	809	12	patel	patel	PROPN
admet-923	809	13	,	,	PUNCT
admet-923	809	14	s.m	s.m	PROPN
admet-923	809	15	.	.	PROPN
admet-923	809	16	pathak	pathak	PROPN
admet-923	809	17	,	,	PUNCT
admet-923	809	18	s.	s.	PROPN
admet-923	809	19	polak	polak	PROPN
admet-923	809	20	,	,	PUNCT
admet-923	809	21	m.	m.	PROPN
admet-923	809	22	jamei	jamei	PROPN
admet-923	809	23	,	,	PUNCT
admet-923	809	24	j.	j.	PROPN
admet-923	809	25	dressman	dressman	PROPN
admet-923	809	26	,	,	PUNCT
admet-923	809	27	a.	a.	PROPN
admet-923	809	28	rostami	rostami	PROPN
admet-923	809	29	-	-	PUNCT
admet-923	809	30	hodjegan	hodjegan	PROPN
admet-923	809	31	.	.	PUNCT
admet-923	810	1	comment	comment	NOUN
admet-923	810	2	on	on	ADP
admet-923	810	3	“	"	PUNCT
admet-923	810	4	in	in	ADP
admet-923	810	5	silico	silico	NOUN
admet-923	810	6	modeling	modeling	NOUN
admet-923	810	7	of	of	ADP
admet-923	810	8	gastrointestinal	gastrointestinal	ADJ
admet-923	810	9	drug	drug	NOUN
admet-923	810	10	absorption	absorption	NOUN
admet-923	810	11	:	:	PUNCT
admet-923	810	12	predictive	predictive	ADJ
admet-923	810	13	performance	performance	NOUN
admet-923	810	14	of	of	ADP
admet-923	810	15	three	three	NUM
admet-923	810	16	physiologically	physiologically	ADV
admet-923	810	17	-	-	PUNCT
admet-923	810	18	based	base	VERB
admet-923	810	19	absorption	absorption	NOUN
admet-923	810	20	models	model	NOUN
admet-923	810	21	.	.	PUNCT
admet-923	810	22	”	"	PUNCT
admet-923	811	1	mol	mol	PROPN
admet-923	811	2	.	.	PUNCT
admet-923	811	3	pharm	pharm	PROPN
admet-923	811	4	.	.	PUNCT
admet-923	812	1	14	14	NUM
admet-923	812	2	(	(	PUNCT
admet-923	812	3	2017	2017	NUM
admet-923	812	4	)	)	PUNCT
admet-923	813	1	336–339	336–339	NUM
admet-923	813	2	.	.	PUNCT
admet-923	814	1	[	[	X
admet-923	814	2	26	26	NUM
admet-923	814	3	]	]	X
admet-923	814	4	f.	f.	PROPN
admet-923	814	5	gotch	gotch	PROPN
admet-923	814	6	,	,	PUNCT
admet-923	814	7	j.	j.	PROPN
admet-923	814	8	nadell	nadell	PROPN
admet-923	814	9	,	,	PUNCT
admet-923	814	10	i.s	i.s	PROPN
admet-923	814	11	.	.	PROPN
admet-923	814	12	edelman	edelman	PROPN
admet-923	814	13	,	,	PUNCT
admet-923	814	14	others	other	NOUN
admet-923	814	15	.	.	PUNCT
admet-923	815	1	gastrointestinal	gastrointestinal	ADJ
admet-923	815	2	water	water	NOUN
admet-923	815	3	and	and	CCONJ
admet-923	815	4	electrolytes	electrolyte	NOUN
admet-923	815	5	.	.	PUNCT
admet-923	816	1	iv	iv	X
admet-923	816	2	.	.	PUNCT
admet-923	817	1	the	the	DET
admet-923	817	2	equilibration	equilibration	NOUN
admet-923	817	3	of	of	ADP
admet-923	817	4	deuterium	deuterium	NOUN
admet-923	817	5	oxide	oxide	NOUN
admet-923	817	6	(	(	PUNCT
admet-923	817	7	d	d	PROPN
admet-923	817	8	2	2	NUM
admet-923	817	9	o	o	NOUN
admet-923	817	10	)	)	PUNCT
admet-923	817	11	in	in	ADP
admet-923	817	12	gastrointestinal	gastrointestinal	ADJ
admet-923	817	13	contents	content	NOUN
admet-923	817	14	and	and	CCONJ
admet-923	817	15	the	the	DET
admet-923	817	16	proportion	proportion	NOUN
admet-923	817	17	of	of	ADP
admet-923	817	18	total	total	ADJ
admet-923	817	19	body	body	NOUN
admet-923	817	20	water	water	NOUN
admet-923	817	21	(	(	PUNCT
admet-923	817	22	tbw	tbw	PROPN
admet-923	817	23	)	)	PUNCT
admet-923	817	24	in	in	ADP
admet-923	817	25	the	the	DET
admet-923	817	26	gastrointestinal	gastrointestinal	ADJ
admet-923	817	27	tract	tract	NOUN
admet-923	817	28	.	.	PUNCT
admet-923	818	1	j.	j.	PROPN
admet-923	818	2	clin	clin	PROPN
admet-923	818	3	.	.	PUNCT
admet-923	819	1	invest	invest	VERB
admet-923	819	2	.	.	PUNCT
admet-923	820	1	36	36	NUM
admet-923	820	2	(	(	PUNCT
admet-923	820	3	1957	1957	NUM
admet-923	820	4	)	)	PUNCT
admet-923	821	1	289–296	289–296	NUM
admet-923	821	2	.	.	PUNCT
admet-923	822	1	[	[	X
admet-923	822	2	27	27	NUM
admet-923	822	3	]	]	X
admet-923	822	4	e.l	e.l	PROPN
admet-923	822	5	.	.	PROPN
admet-923	822	6	mcconnell	mcconnell	PROPN
admet-923	822	7	,	,	PUNCT
admet-923	822	8	h.m	h.m	PROPN
admet-923	822	9	.	.	PROPN
admet-923	822	10	fadda	fadda	PROPN
admet-923	822	11	,	,	PUNCT
admet-923	822	12	a.w	a.w	PROPN
admet-923	822	13	.	.	PROPN
admet-923	822	14	basit	basit	PROPN
admet-923	822	15	.	.	PUNCT
admet-923	823	1	gut	gut	NOUN
admet-923	823	2	instincts	instinct	NOUN
admet-923	823	3	:	:	PUNCT
admet-923	823	4	explorations	exploration	NOUN
admet-923	823	5	in	in	ADP
admet-923	823	6	intestinal	intestinal	ADJ
admet-923	823	7	physiology	physiology	NOUN
admet-923	823	8	and	and	CCONJ
admet-923	823	9	drug	drug	NOUN
admet-923	823	10	delivery	delivery	NOUN
admet-923	823	11	.	.	PUNCT
admet-923	824	1	int	int	NOUN
admet-923	824	2	.	.	PUNCT
admet-923	825	1	j.	j.	PROPN
admet-923	825	2	pharm	pharm	PROPN
admet-923	825	3	.	.	PUNCT
admet-923	826	1	364	364	NUM
admet-923	826	2	(	(	PUNCT
admet-923	826	3	2008	2008	NUM
admet-923	826	4	)	)	PUNCT
admet-923	827	1	213–226	213–226	NUM
admet-923	827	2	.	.	PUNCT
admet-923	828	1	[	[	X
admet-923	828	2	28	28	NUM
admet-923	828	3	]	]	X
admet-923	828	4	d.m	d.m	PROPN
admet-923	828	5	.	.	PROPN
admet-923	828	6	mudie	mudie	PROPN
admet-923	828	7	,	,	PUNCT
admet-923	828	8	g.l	g.l	PROPN
admet-923	828	9	.	.	PROPN
admet-923	828	10	amidon	amidon	PROPN
admet-923	828	11	,	,	PUNCT
admet-923	828	12	g.e	g.e	PROPN
admet-923	828	13	.	.	PROPN
admet-923	828	14	amidon	amidon	PROPN
admet-923	828	15	,	,	PUNCT
admet-923	828	16	k.	k.	PROPN
admet-923	828	17	murray	murray	PROPN
admet-923	828	18	,	,	PUNCT
admet-923	828	19	c.l	c.l	PROPN
admet-923	828	20	.	.	PROPN
admet-923	828	21	hoad	hoad	PROPN
admet-923	828	22	,	,	PUNCT
admet-923	828	23	s.e	s.e	PROPN
admet-923	828	24	.	.	PROPN
admet-923	828	25	pritchard	pritchard	PROPN
admet-923	828	26	,	,	PUNCT
admet-923	828	27	p.a	p.a	PROPN
admet-923	828	28	.	.	PROPN
admet-923	828	29	gowland	gowland	PROPN
admet-923	828	30	,	,	PUNCT
admet-923	828	31	m.c	m.c	PROPN
admet-923	828	32	.	.	PROPN
admet-923	828	33	garnett	garnett	PROPN
admet-923	828	34	,	,	PUNCT
admet-923	828	35	r.c	r.c	PROPN
admet-923	828	36	.	.	PROPN
admet-923	828	37	spiller	spiller	PROPN
admet-923	828	38	,	,	PUNCT
admet-923	828	39	l.	l.	PROPN
admet-923	828	40	marciani	marciani	PROPN
admet-923	828	41	.	.	PUNCT
admet-923	829	1	quantification	quantification	NOUN
admet-923	829	2	of	of	ADP
admet-923	829	3	gastrointestinal	gastrointestinal	ADJ
admet-923	829	4	liquid	liquid	ADJ
admet-923	829	5	volumes	volume	NOUN
admet-923	829	6	and	and	CCONJ
admet-923	829	7	distribution	distribution	NOUN
admet-923	829	8	following	follow	VERB
admet-923	829	9	a	a	DET
admet-923	829	10	240	240	NUM
admet-923	829	11	ml	ml	NOUN
admet-923	829	12	dose	dose	NOUN
admet-923	829	13	of	of	ADP
admet-923	829	14	water	water	NOUN
admet-923	829	15	in	in	ADP
admet-923	829	16	the	the	DET
admet-923	829	17	fasted	fasted	ADJ
admet-923	829	18	state	state	NOUN
admet-923	829	19	.	.	PUNCT
admet-923	830	1	mol	mol	PROPN
admet-923	830	2	.	.	PUNCT
admet-923	830	3	pharm	pharm	PROPN
admet-923	830	4	.	.	PUNCT
admet-923	831	1	11	11	NUM
admet-923	831	2	(	(	PUNCT
admet-923	831	3	2014	2014	NUM
admet-923	831	4	)	)	PUNCT
admet-923	831	5	3039–3047	3039–3047	NUM
admet-923	831	6	.	.	PUNCT
admet-923	832	1	[	[	X
admet-923	832	2	29	29	NUM
admet-923	832	3	]	]	X
admet-923	832	4	c.	c.	PROPN
admet-923	832	5	schiller	schiller	PROPN
admet-923	832	6	,	,	PUNCT
admet-923	832	7	c.p	c.p	PROPN
admet-923	832	8	.	.	PROPN
admet-923	832	9	fröhlich	fröhlich	PROPN
admet-923	832	10	,	,	PUNCT
admet-923	832	11	t.	t.	PROPN
admet-923	832	12	giessmann	giessmann	PROPN
admet-923	832	13	,	,	PUNCT
admet-923	832	14	w.	w.	PROPN
admet-923	832	15	siegmund	siegmund	PROPN
admet-923	832	16	,	,	PUNCT
admet-923	832	17	h.	h.	PROPN
admet-923	832	18	mönnikes	mönnikes	PROPN
admet-923	832	19	,	,	PUNCT
admet-923	832	20	n.	n.	NOUN
admet-923	832	21	hosten	hosten	PROPN
admet-923	832	22	,	,	PUNCT
admet-923	832	23	w.	w.	PROPN
admet-923	832	24	weitschies	weitschie	NOUN
admet-923	832	25	.	.	PUNCT
admet-923	833	1	intestinal	intestinal	ADJ
admet-923	833	2	fluid	fluid	ADJ
admet-923	833	3	volumes	volume	NOUN
admet-923	833	4	and	and	CCONJ
admet-923	833	5	transit	transit	NOUN
admet-923	833	6	of	of	ADP
admet-923	833	7	dosage	dosage	NOUN
admet-923	833	8	forms	form	NOUN
admet-923	833	9	as	as	SCONJ
admet-923	833	10	assessed	assess	VERB
admet-923	833	11	by	by	ADP
admet-923	833	12	magnetic	magnetic	ADJ
admet-923	833	13	resonance	resonance	NOUN
admet-923	833	14	imaging	imaging	NOUN
admet-923	833	15	.	.	PUNCT
admet-923	834	1	aliment	aliment	NOUN
admet-923	834	2	.	.	PUNCT
admet-923	835	1	pharmacol	pharmacol	PROPN
admet-923	835	2	.	.	PUNCT
admet-923	836	1	ther	ther	PROPN
admet-923	836	2	.	.	PUNCT
admet-923	837	1	22	22	NUM
admet-923	837	2	(	(	PUNCT
admet-923	837	3	2005	2005	NUM
admet-923	837	4	)	)	PUNCT
admet-923	838	1	971–979	971–979	NUM
admet-923	838	2	.	.	PUNCT
admet-923	839	1	[	[	X
admet-923	839	2	30	30	NUM
admet-923	839	3	]	]	X
admet-923	839	4	f.l	f.l	PROPN
admet-923	839	5	.	.	PROPN
admet-923	839	6	wood	wood	PROPN
admet-923	839	7	,	,	PUNCT
admet-923	839	8	j.b	j.b	PROPN
admet-923	839	9	.	.	PROPN
admet-923	839	10	houston	houston	PROPN
admet-923	839	11	,	,	PUNCT
admet-923	839	12	d.	d.	PROPN
admet-923	839	13	hallifax	hallifax	PROPN
admet-923	839	14	.	.	PUNCT
admet-923	840	1	clearance	clearance	NOUN
admet-923	840	2	prediction	prediction	NOUN
admet-923	840	3	methodology	methodology	NOUN
admet-923	840	4	needs	need	VERB
admet-923	840	5	fundamental	fundamental	ADJ
admet-923	840	6	improvement	improvement	NOUN
admet-923	840	7	:	:	PUNCT
admet-923	840	8	trends	trend	NOUN
admet-923	840	9	common	common	ADJ
admet-923	840	10	to	to	ADP
admet-923	840	11	rat	rat	NOUN
admet-923	840	12	and	and	CCONJ
admet-923	840	13	human	human	ADJ
admet-923	840	14	hepatocytes	hepatocyte	NOUN
admet-923	840	15	/	/	SYM
admet-923	840	16	microsomes	microsome	NOUN
admet-923	840	17	and	and	CCONJ
admet-923	840	18	implications	implication	NOUN
admet-923	840	19	for	for	ADP
admet-923	840	20	experimental	experimental	ADJ
admet-923	840	21	methodology	methodology	NOUN
admet-923	840	22	.	.	PUNCT
admet-923	841	1	drug	drug	NOUN
admet-923	841	2	metab	metab	PROPN
admet-923	841	3	.	.	PUNCT
admet-923	842	1	dispos	dispos	PROPN
admet-923	842	2	.	.	PUNCT
admet-923	843	1	45	45	NUM
admet-923	843	2	(	(	PUNCT
admet-923	843	3	2017	2017	NUM
admet-923	843	4	)	)	PUNCT
admet-923	843	5	1178–1188	1178–1188	NUM
admet-923	843	6	.	.	PUNCT
admet-923	844	1	[	[	X
admet-923	844	2	31	31	NUM
admet-923	844	3	]	]	PUNCT
admet-923	844	4	h.	h.	PROPN
admet-923	844	5	lennernäs	lennernäs	PROPN
admet-923	844	6	.	.	PUNCT
admet-923	845	1	animal	animal	NOUN
admet-923	845	2	data	datum	NOUN
admet-923	845	3	:	:	PUNCT
admet-923	845	4	the	the	DET
admet-923	845	5	contributions	contribution	NOUN
admet-923	845	6	of	of	ADP
admet-923	845	7	the	the	DET
admet-923	845	8	ussing	ussing	ADJ
admet-923	845	9	chamber	chamber	NOUN
admet-923	845	10	and	and	CCONJ
admet-923	845	11	perfusion	perfusion	NOUN
admet-923	845	12	systems	system	NOUN
admet-923	845	13	to	to	ADP
admet-923	845	14	predicting	predict	VERB
admet-923	845	15	human	human	ADJ
admet-923	845	16	oral	oral	ADJ
admet-923	845	17	drug	drug	NOUN
admet-923	845	18	delivery	delivery	NOUN
admet-923	845	19	in	in	ADP
admet-923	845	20	vivo	vivo	NOUN
admet-923	845	21	.	.	PUNCT
admet-923	846	1	adv	adv	PROPN
admet-923	846	2	.	.	PUNCT
admet-923	846	3	drug	drug	PROPN
admet-923	846	4	deliv	deliv	PROPN
admet-923	846	5	.	.	PUNCT
admet-923	847	1	rev	rev	PROPN
admet-923	847	2	.	.	PROPN
admet-923	847	3	59	59	NUM
admet-923	847	4	(	(	PUNCT
admet-923	847	5	2007	2007	NUM
admet-923	847	6	)	)	PUNCT
admet-923	847	7	1103–1120	1103–1120	NUM
admet-923	847	8	.	.	PUNCT
admet-923	848	1	[	[	X
admet-923	848	2	32	32	NUM
admet-923	848	3	]	]	PUNCT
admet-923	848	4	m.	m.	NOUN
admet-923	848	5	banwarth	banwarth	PROPN
admet-923	848	6	-	-	PUNCT
admet-923	848	7	kuhn	kuhn	PROPN
admet-923	848	8	,	,	PUNCT
admet-923	848	9	s.	s.	PROPN
admet-923	848	10	sindi	sindi	PROPN
admet-923	848	11	.	.	PUNCT
admet-923	849	1	how	how	SCONJ
admet-923	849	2	and	and	CCONJ
admet-923	849	3	why	why	SCONJ
admet-923	849	4	to	to	PART
admet-923	849	5	build	build	VERB
admet-923	849	6	a	a	DET
admet-923	849	7	mathematical	mathematical	ADJ
admet-923	849	8	model	model	NOUN
admet-923	849	9	:	:	PUNCT
admet-923	849	10	a	a	DET
admet-923	849	11	case	case	NOUN
admet-923	849	12	study	study	NOUN
admet-923	849	13	using	use	VERB
admet-923	849	14	prion	prion	NOUN
admet-923	849	15	aggregation	aggregation	NOUN
admet-923	849	16	.	.	PUNCT
admet-923	850	1	j.	j.	PROPN
admet-923	850	2	biol	biol	PROPN
admet-923	850	3	.	.	PUNCT
admet-923	851	1	chem	chem	PROPN
admet-923	851	2	.	.	PUNCT
admet-923	852	1	295	295	NUM
admet-923	852	2	(	(	PUNCT
admet-923	852	3	2020	2020	NUM
admet-923	852	4	)	)	PUNCT
admet-923	852	5	5022–5035	5022–5035	NUM
admet-923	852	6	.	.	PUNCT
admet-923	853	1	[	[	X
admet-923	853	2	33	33	NUM
admet-923	853	3	]	]	X
admet-923	853	4	j.w.t	j.w.t	PROPN
admet-923	853	5	.	.	PUNCT
admet-923	854	1	yates	yates	PROPN
admet-923	854	2	,	,	PUNCT
admet-923	854	3	r.d.o	r.d.o	PROPN
admet-923	854	4	.	.	PROPN
admet-923	854	5	jones	jones	PROPN
admet-923	854	6	,	,	PUNCT
admet-923	854	7	m.	m.	PROPN
admet-923	854	8	walker	walker	PROPN
admet-923	854	9	,	,	PUNCT
admet-923	854	10	s.y.a	s.y.a	PROPN
admet-923	854	11	.	.	PUNCT
admet-923	854	12	cheung	cheung	PROPN
admet-923	854	13	.	.	PUNCT
admet-923	855	1	structural	structural	ADJ
admet-923	855	2	identifiability	identifiability	NOUN
admet-923	855	3	and	and	CCONJ
admet-923	855	4	indistinguishability	indistinguishability	NOUN
admet-923	855	5	of	of	ADP
admet-923	855	6	compartmental	compartmental	ADJ
admet-923	855	7	models	model	NOUN
admet-923	855	8	.	.	PUNCT
admet-923	856	1	expert	expert	NOUN
admet-923	856	2	opin	opin	NOUN
admet-923	856	3	.	.	PUNCT
admet-923	857	1	drug	drug	NOUN
admet-923	857	2	metab	metab	NOUN
admet-923	857	3	.	.	PUNCT
admet-923	858	1	toxicol	toxicol	PROPN
admet-923	858	2	.	.	PUNCT
admet-923	859	1	5	5	NUM
admet-923	859	2	(	(	PUNCT
admet-923	859	3	2009	2009	NUM
admet-923	859	4	)	)	PUNCT
admet-923	860	1	295–302	295–302	NUM
admet-923	860	2	.	.	PUNCT
admet-923	861	1	[	[	X
admet-923	861	2	34	34	NUM
admet-923	861	3	]	]	X
admet-923	861	4	c.	c.	PROPN
admet-923	861	5	cobelli	cobelli	PROPN
admet-923	861	6	,	,	PUNCT
admet-923	861	7	j.j	j.j	PROPN
admet-923	861	8	.	.	PROPN
admet-923	861	9	distefano	distefano	PROPN
admet-923	861	10	3rd	3rd	NOUN
admet-923	861	11	.	.	PUNCT
admet-923	862	1	parameter	parameter	NOUN
admet-923	862	2	and	and	CCONJ
admet-923	862	3	structural	structural	ADJ
admet-923	862	4	identifiability	identifiability	NOUN
admet-923	862	5	concepts	concept	NOUN
admet-923	862	6	and	and	CCONJ
admet-923	862	7	ambiguities	ambiguity	NOUN
admet-923	862	8	:	:	PUNCT
admet-923	862	9	a	a	DET
admet-923	862	10	critical	critical	ADJ
admet-923	862	11	review	review	NOUN
admet-923	862	12	and	and	CCONJ
admet-923	862	13	analysis	analysis	NOUN
admet-923	862	14	.	.	PUNCT
admet-923	863	1	am	be	AUX
admet-923	863	2	.	.	PUNCT
admet-923	864	1	j.	j.	PROPN
admet-923	864	2	physiol	physiol	PROPN
admet-923	864	3	.	.	PUNCT
admet-923	865	1	integr	integr	PROPN
admet-923	865	2	.	.	PUNCT
admet-923	866	1	comp	comp	PROPN
admet-923	866	2	.	.	PUNCT
admet-923	867	1	physiol	physiol	PROPN
admet-923	867	2	.	.	PUNCT
admet-923	868	1	239	239	NUM
admet-923	868	2	(	(	PUNCT
admet-923	868	3	1980	1980	NUM
admet-923	868	4	)	)	PUNCT
admet-923	868	5	r7	r7	NOUN
admet-923	868	6	-	-	PUNCT
admet-923	868	7	-r24	-r24	NOUN
admet-923	868	8	.	.	PUNCT
admet-923	869	1	[	[	X
admet-923	869	2	35	35	NUM
admet-923	869	3	]	]	PUNCT
admet-923	869	4	k.	k.	PROPN
admet-923	869	5	sugano	sugano	PROPN
admet-923	869	6	.	.	PUNCT
admet-923	870	1	introduction	introduction	NOUN
admet-923	870	2	to	to	ADP
admet-923	870	3	computational	computational	ADJ
admet-923	870	4	oral	oral	ADJ
admet-923	870	5	absorption	absorption	NOUN
admet-923	870	6	simulation	simulation	NOUN
admet-923	870	7	.	.	PUNCT
admet-923	871	1	expert	expert	NOUN
admet-923	871	2	opin	opin	NOUN
admet-923	871	3	.	.	PUNCT
admet-923	872	1	drug	drug	NOUN
admet-923	872	2	metab	metab	NOUN
admet-923	872	3	.	.	PUNCT
admet-923	873	1	toxicol	toxicol	PROPN
admet-923	873	2	.	.	PUNCT
admet-923	874	1	5	5	NUM
admet-923	874	2	(	(	PUNCT
admet-923	874	3	2009	2009	NUM
admet-923	874	4	)	)	PUNCT
admet-923	874	5	.	.	PUNCT
admet-923	875	1	admet	admet	PROPN
admet-923	875	2	&	&	CCONJ
admet-923	875	3	dmpk	dmpk	PROPN
admet-923	875	4	9(2	9(2	NUM
admet-923	875	5	)	)	PUNCT
admet-923	875	6	(	(	PUNCT
admet-923	875	7	2021	2021	NUM
admet-923	875	8	)	)	PUNCT
admet-923	875	9	75	75	NUM
admet-923	875	10	-	-	SYM
admet-923	875	11	109	109	NUM
admet-923	875	12	lost	lose	VERB
admet-923	875	13	in	in	ADP
admet-923	875	14	modelling	modelling	NOUN
admet-923	875	15	and	and	CCONJ
admet-923	875	16	simulation	simulation	NOUN
admet-923	875	17	?	?	PUNCT
admet-923	876	1	doi	doi	NOUN
admet-923	876	2	:	:	PUNCT
admet-923	876	3	https:/doi.org/10.5599	https:/doi.org/10.5599	PROPN
admet-923	876	4	/	/	SYM
admet-923	876	5	admet.923	admet.923	PROPN
admet-923	876	6	101	101	NUM
admet-923	876	7	[	[	X
admet-923	876	8	36	36	NUM
admet-923	876	9	]	]	PUNCT
admet-923	876	10	k.	k.	PROPN
admet-923	876	11	sugano	sugano	PROPN
admet-923	876	12	.	.	PUNCT
admet-923	877	1	biopharmaceutics	biopharmaceutics	NOUN
admet-923	877	2	modeling	modeling	NOUN
admet-923	877	3	and	and	CCONJ
admet-923	877	4	simulations	simulation	NOUN
admet-923	877	5	:	:	PUNCT
admet-923	878	1	theory	theory	NOUN
admet-923	878	2	,	,	PUNCT
admet-923	878	3	practice	practice	NOUN
admet-923	878	4	,	,	PUNCT
admet-923	878	5	methods	method	NOUN
admet-923	878	6	,	,	PUNCT
admet-923	878	7	and	and	CCONJ
admet-923	878	8	applications	application	NOUN
admet-923	878	9	,	,	PUNCT
admet-923	878	10	2012	2012	NUM
admet-923	878	11	.	.	PUNCT
admet-923	879	1	[	[	X
admet-923	879	2	37	37	NUM
admet-923	879	3	]	]	PUNCT
admet-923	879	4	l.	l.	PROPN
admet-923	879	5	kuepfer	kuepfer	PROPN
admet-923	879	6	,	,	PUNCT
admet-923	879	7	c.	c.	NOUN
admet-923	879	8	niederalt	niederalt	NOUN
admet-923	879	9	,	,	PUNCT
admet-923	879	10	t.	t.	PROPN
admet-923	879	11	wendl	wendl	PROPN
admet-923	879	12	,	,	PUNCT
admet-923	879	13	j.-f	j.-f	PROPN
admet-923	879	14	.	.	PUNCT
admet-923	880	1	schlender	schlender	PROPN
admet-923	880	2	,	,	PUNCT
admet-923	880	3	s.	s.	PROPN
admet-923	880	4	willmann	willmann	PROPN
admet-923	880	5	,	,	PUNCT
admet-923	880	6	j.	j.	PROPN
admet-923	880	7	lippert	lippert	PROPN
admet-923	880	8	,	,	PUNCT
admet-923	880	9	m.	m.	NOUN
admet-923	880	10	block	block	NOUN
admet-923	880	11	,	,	PUNCT
admet-923	880	12	t.	t.	PROPN
admet-923	880	13	eissing	eissing	NOUN
admet-923	880	14	,	,	PUNCT
admet-923	880	15	d.	d.	PROPN
admet-923	880	16	teutonico	teutonico	PROPN
admet-923	880	17	.	.	PUNCT
admet-923	881	1	applied	apply	VERB
admet-923	881	2	concepts	concept	NOUN
admet-923	881	3	in	in	ADP
admet-923	881	4	pbpk	pbpk	NOUN
admet-923	881	5	modeling	modeling	NOUN
admet-923	881	6	:	:	PUNCT
admet-923	881	7	how	how	SCONJ
admet-923	881	8	to	to	PART
admet-923	881	9	build	build	VERB
admet-923	881	10	a	a	DET
admet-923	881	11	pbpk	pbpk	ADJ
admet-923	881	12	/	/	SYM
admet-923	881	13	pd	pd	PROPN
admet-923	881	14	model	model	NOUN
admet-923	881	15	.	.	PUNCT
admet-923	882	1	cpt	cpt	PROPN
admet-923	882	2	pharmacometrics	pharmacometrics	PROPN
admet-923	882	3	syst	syst	PROPN
admet-923	882	4	.	.	PUNCT
admet-923	883	1	pharmacol	pharmacol	PROPN
admet-923	883	2	.	.	PROPN
admet-923	884	1	5	5	NUM
admet-923	884	2	(	(	PUNCT
admet-923	884	3	2016	2016	NUM
admet-923	884	4	)	)	PUNCT
admet-923	885	1	516–531	516–531	NUM
admet-923	885	2	.	.	PUNCT
admet-923	886	1	[	[	X
admet-923	886	2	38	38	NUM
admet-923	886	3	]	]	PUNCT
admet-923	886	4	k.	k.	PROPN
admet-923	886	5	sugano	sugano	PROPN
admet-923	886	6	.	.	PUNCT
admet-923	887	1	emerging	emerge	VERB
admet-923	887	2	full	full	ADJ
admet-923	887	3	mechanistic	mechanistic	ADJ
admet-923	887	4	physiologically	physiologically	ADV
admet-923	887	5	based	base	VERB
admet-923	887	6	modeling	modeling	NOUN
admet-923	887	7	,	,	PUNCT
admet-923	887	8	2014	2014	NUM
admet-923	887	9	.	.	PUNCT
admet-923	888	1	[	[	X
admet-923	888	2	39	39	NUM
admet-923	888	3	]	]	PUNCT
admet-923	888	4	e.g.	e.g.	ADV
admet-923	888	5	rippie	rippie	NOUN
admet-923	888	6	,	,	PUNCT
admet-923	888	7	d.j	d.j	PROPN
admet-923	888	8	.	.	PROPN
admet-923	888	9	lamb	lamb	PROPN
admet-923	888	10	,	,	PUNCT
admet-923	888	11	p.w	p.w	PROPN
admet-923	888	12	.	.	PUNCT
admet-923	888	13	romig	romig	NOUN
admet-923	888	14	.	.	PUNCT
admet-923	889	1	solubilization	solubilization	NOUN
admet-923	889	2	of	of	ADP
admet-923	889	3	weakly	weakly	ADJ
admet-923	889	4	acidic	acidic	ADJ
admet-923	889	5	and	and	CCONJ
admet-923	889	6	basic	basic	ADJ
admet-923	889	7	drugs	drug	NOUN
admet-923	889	8	by	by	ADP
admet-923	889	9	aqueous	aqueous	ADJ
admet-923	889	10	solutions	solution	NOUN
admet-923	889	11	of	of	ADP
admet-923	889	12	polysorbate	polysorbate	NOUN
admet-923	889	13	80	80	NUM
admet-923	889	14	.	.	PUNCT
admet-923	890	1	j.	j.	PROPN
admet-923	890	2	pharm	pharm	PROPN
admet-923	890	3	.	.	PUNCT
admet-923	891	1	sci	sci	PROPN
admet-923	891	2	.	.	PROPN
admet-923	892	1	53	53	NUM
admet-923	892	2	(	(	PUNCT
admet-923	892	3	1964	1964	NUM
admet-923	892	4	)	)	PUNCT
admet-923	892	5	1346–1348	1346–1348	NOUN
admet-923	892	6	.	.	PUNCT
admet-923	893	1	[	[	X
admet-923	893	2	40	40	NUM
admet-923	893	3	]	]	PUNCT
admet-923	893	4	j.	j.	PROPN
admet-923	893	5	jinno	jinno	PROPN
admet-923	893	6	,	,	PUNCT
admet-923	893	7	d.	d.	PROPN
admet-923	893	8	oh	oh	INTJ
admet-923	893	9	,	,	PUNCT
admet-923	893	10	j.r	j.r	PROPN
admet-923	893	11	.	.	PROPN
admet-923	893	12	crison	crison	PROPN
admet-923	893	13	,	,	PUNCT
admet-923	893	14	g.l	g.l	PROPN
admet-923	893	15	.	.	PROPN
admet-923	893	16	amidon	amidon	PROPN
admet-923	893	17	.	.	PUNCT
admet-923	894	1	dissolution	dissolution	NOUN
admet-923	894	2	of	of	ADP
admet-923	894	3	ionizable	ionizable	ADJ
admet-923	894	4	water	water	NOUN
admet-923	894	5	-	-	PUNCT
admet-923	894	6	insoluble	insoluble	ADJ
admet-923	894	7	drugs	drug	NOUN
admet-923	894	8	:	:	PUNCT
admet-923	894	9	the	the	DET
admet-923	894	10	combined	combined	ADJ
admet-923	894	11	effect	effect	NOUN
admet-923	894	12	of	of	ADP
admet-923	894	13	ph	ph	NOUN
admet-923	894	14	and	and	CCONJ
admet-923	894	15	surfactant	surfactant	NOUN
admet-923	894	16	.	.	PUNCT
admet-923	895	1	j.	j.	PROPN
admet-923	895	2	pharm	pharm	PROPN
admet-923	895	3	.	.	PUNCT
admet-923	896	1	sci	sci	PROPN
admet-923	896	2	.	.	PROPN
admet-923	896	3	89	89	NUM
admet-923	896	4	(	(	PUNCT
admet-923	896	5	2000	2000	NUM
admet-923	896	6	)	)	PUNCT
admet-923	896	7	268–274	268–274	NUM
admet-923	896	8	.	.	PUNCT
admet-923	897	1	[	[	X
admet-923	897	2	41	41	NUM
admet-923	897	3	]	]	X
admet-923	897	4	a.a	a.a	PROPN
admet-923	897	5	.	.	PROPN
admet-923	897	6	noyes	noyes	PROPN
admet-923	897	7	,	,	PUNCT
admet-923	897	8	w.r	w.r	PROPN
admet-923	897	9	.	.	PROPN
admet-923	897	10	whitney	whitney	PROPN
admet-923	897	11	.	.	PUNCT
admet-923	898	1	the	the	DET
admet-923	898	2	rate	rate	NOUN
admet-923	898	3	of	of	ADP
admet-923	898	4	solution	solution	NOUN
admet-923	898	5	of	of	ADP
admet-923	898	6	solid	solid	ADJ
admet-923	898	7	substances	substance	NOUN
admet-923	898	8	in	in	ADP
admet-923	898	9	their	their	PRON
admet-923	898	10	own	own	ADJ
admet-923	898	11	solutions	solution	NOUN
admet-923	898	12	.	.	PUNCT
admet-923	899	1	j.	j.	PROPN
admet-923	899	2	am	am	PROPN
admet-923	899	3	.	.	PUNCT
admet-923	900	1	chem	chem	NOUN
admet-923	900	2	.	.	PUNCT
admet-923	901	1	soc	soc	PROPN
admet-923	901	2	.	.	PUNCT
admet-923	902	1	19	19	NUM
admet-923	902	2	(	(	PUNCT
admet-923	902	3	1897	1897	NUM
admet-923	902	4	)	)	PUNCT
admet-923	903	1	930–934	930–934	NUM
admet-923	903	2	.	.	PUNCT
admet-923	904	1	[	[	X
admet-923	904	2	42	42	NUM
admet-923	904	3	]	]	X
admet-923	904	4	k.g	k.g	PROPN
admet-923	904	5	.	.	PROPN
admet-923	904	6	mooney	mooney	PROPN
admet-923	904	7	,	,	PUNCT
admet-923	904	8	m.a	m.a	PROPN
admet-923	904	9	.	.	PROPN
admet-923	904	10	mintun	mintun	PROPN
admet-923	904	11	,	,	PUNCT
admet-923	904	12	k.j	k.j	PROPN
admet-923	904	13	.	.	PROPN
admet-923	904	14	himmelstein	himmelstein	PROPN
admet-923	904	15	,	,	PUNCT
admet-923	904	16	v.j	v.j	PROPN
admet-923	904	17	.	.	PROPN
admet-923	904	18	stella	stella	PROPN
admet-923	904	19	.	.	PUNCT
admet-923	905	1	dissolution	dissolution	PROPN
admet-923	905	2	kinetics	kinetic	NOUN
admet-923	905	3	of	of	ADP
admet-923	905	4	carboxylic	carboxylic	ADJ
admet-923	905	5	acids	acid	NOUN
admet-923	905	6	i	i	PRON
admet-923	905	7	:	:	PUNCT
admet-923	905	8	effect	effect	NOUN
admet-923	905	9	of	of	ADP
admet-923	905	10	ph	ph	NOUN
admet-923	905	11	under	under	ADP
admet-923	905	12	unbuffered	unbuffered	ADJ
admet-923	905	13	conditions	condition	NOUN
admet-923	905	14	.	.	PUNCT
admet-923	906	1	j.	j.	PROPN
admet-923	906	2	pharm	pharm	PROPN
admet-923	906	3	.	.	PUNCT
admet-923	907	1	sci	sci	PROPN
admet-923	907	2	.	.	PROPN
admet-923	908	1	70	70	NUM
admet-923	908	2	(	(	PUNCT
admet-923	908	3	1981	1981	NUM
admet-923	908	4	)	)	PUNCT
admet-923	908	5	13–22	13–22	NUM
admet-923	908	6	.	.	PUNCT
admet-923	909	1	[	[	X
admet-923	909	2	43	43	NUM
admet-923	909	3	]	]	X
admet-923	909	4	k.g	k.g	PROPN
admet-923	909	5	.	.	PROPN
admet-923	909	6	mooney	mooney	PROPN
admet-923	909	7	,	,	PUNCT
admet-923	909	8	m.a	m.a	PROPN
admet-923	909	9	.	.	PROPN
admet-923	909	10	mintun	mintun	PROPN
admet-923	909	11	,	,	PUNCT
admet-923	909	12	k.j	k.j	PROPN
admet-923	909	13	.	.	PROPN
admet-923	909	14	himmelstein	himmelstein	PROPN
admet-923	909	15	,	,	PUNCT
admet-923	909	16	v.j	v.j	PROPN
admet-923	909	17	.	.	PROPN
admet-923	909	18	stella	stella	PROPN
admet-923	909	19	.	.	PUNCT
admet-923	910	1	dissolution	dissolution	PROPN
admet-923	910	2	kinetics	kinetic	NOUN
admet-923	910	3	of	of	ADP
admet-923	910	4	carboxylic	carboxylic	ADJ
admet-923	910	5	acids	acid	NOUN
admet-923	910	6	ii	ii	NOUN
admet-923	910	7	:	:	PUNCT
admet-923	910	8	effect	effect	NOUN
admet-923	910	9	of	of	ADP
admet-923	910	10	buffers	buffer	NOUN
admet-923	910	11	.	.	PUNCT
admet-923	911	1	j.	j.	PROPN
admet-923	911	2	pharm	pharm	PROPN
admet-923	911	3	.	.	PUNCT
admet-923	912	1	sci	sci	PROPN
admet-923	912	2	.	.	PROPN
admet-923	913	1	70	70	NUM
admet-923	913	2	(	(	PUNCT
admet-923	913	3	1981	1981	NUM
admet-923	913	4	)	)	PUNCT
admet-923	913	5	22–32	22–32	NUM
admet-923	913	6	.	.	PUNCT
admet-923	914	1	[	[	X
admet-923	914	2	44	44	NUM
admet-923	914	3	]	]	PUNCT
admet-923	914	4	a.	a.	NOUN
admet-923	914	5	okazaki	okazaki	PROPN
admet-923	914	6	,	,	PUNCT
admet-923	914	7	t.	t.	PROPN
admet-923	914	8	mano	mano	PROPN
admet-923	914	9	,	,	PUNCT
admet-923	914	10	k.	k.	PROPN
admet-923	914	11	sugano	sugano	PROPN
admet-923	914	12	.	.	PUNCT
admet-923	915	1	theoretical	theoretical	ADJ
admet-923	915	2	dissolution	dissolution	NOUN
admet-923	915	3	model	model	NOUN
admet-923	915	4	of	of	ADP
admet-923	915	5	poly	poly	ADJ
admet-923	915	6	-	-	PUNCT
admet-923	915	7	disperse	disperse	NOUN
admet-923	915	8	drug	drug	NOUN
admet-923	915	9	particles	particle	NOUN
admet-923	915	10	in	in	ADP
admet-923	915	11	biorelevant	biorelevant	ADJ
admet-923	915	12	media	medium	NOUN
admet-923	915	13	.	.	PUNCT
admet-923	916	1	j.	j.	PROPN
admet-923	916	2	pharm	pharm	PROPN
admet-923	916	3	.	.	PUNCT
admet-923	917	1	sci	sci	PROPN
admet-923	917	2	.	.	PROPN
admet-923	917	3	97	97	NUM
admet-923	917	4	(	(	PUNCT
admet-923	917	5	2008	2008	NUM
admet-923	917	6	)	)	PUNCT
admet-923	917	7	.	.	PUNCT
admet-923	918	1	[	[	X
admet-923	918	2	45	45	NUM
admet-923	918	3	]	]	X
admet-923	918	4	r.j	r.j	PROPN
admet-923	918	5	.	.	PROPN
admet-923	918	6	hintz	hintz	PROPN
admet-923	918	7	,	,	PUNCT
admet-923	918	8	k.c	k.c	PROPN
admet-923	918	9	.	.	PROPN
admet-923	918	10	johnson	johnson	PROPN
admet-923	918	11	.	.	PUNCT
admet-923	919	1	the	the	DET
admet-923	919	2	effect	effect	NOUN
admet-923	919	3	of	of	ADP
admet-923	919	4	particle	particle	NOUN
admet-923	919	5	size	size	NOUN
admet-923	919	6	distribution	distribution	NOUN
admet-923	919	7	on	on	ADP
admet-923	919	8	dissolution	dissolution	ADJ
admet-923	919	9	rate	rate	NOUN
admet-923	919	10	and	and	CCONJ
admet-923	919	11	oral	oral	ADJ
admet-923	919	12	absorption	absorption	NOUN
admet-923	919	13	.	.	PUNCT
admet-923	920	1	int	int	NOUN
admet-923	920	2	.	.	PUNCT
admet-923	921	1	j.	j.	PROPN
admet-923	921	2	pharm	pharm	PROPN
admet-923	921	3	.	.	PUNCT
admet-923	922	1	51	51	NUM
admet-923	922	2	(	(	PUNCT
admet-923	922	3	1989	1989	NUM
admet-923	922	4	)	)	PUNCT
admet-923	922	5	9–17	9–17	NOUN
admet-923	922	6	.	.	PUNCT
admet-923	923	1	[	[	X
admet-923	923	2	46	46	NUM
admet-923	923	3	]	]	PUNCT
admet-923	923	4	j.	j.	PROPN
admet-923	923	5	wang	wang	PROPN
admet-923	923	6	,	,	PUNCT
admet-923	923	7	d.r	d.r	PROPN
admet-923	923	8	.	.	PROPN
admet-923	923	9	flanagan	flanagan	PROPN
admet-923	923	10	.	.	PUNCT
admet-923	924	1	general	general	ADJ
admet-923	924	2	solution	solution	NOUN
admet-923	924	3	for	for	ADP
admet-923	924	4	diffusion	diffusion	NOUN
admet-923	924	5	-	-	PUNCT
admet-923	924	6	controlled	control	VERB
admet-923	924	7	dissolution	dissolution	NOUN
admet-923	924	8	of	of	ADP
admet-923	924	9	spherical	spherical	ADJ
admet-923	924	10	particles	particle	NOUN
admet-923	924	11	.	.	PUNCT
admet-923	925	1	1	1	X
admet-923	925	2	.	.	X
admet-923	925	3	theory	theory	NOUN
admet-923	925	4	.	.	PUNCT
admet-923	926	1	j.	j.	PROPN
admet-923	926	2	pharm	pharm	PROPN
admet-923	926	3	.	.	PUNCT
admet-923	927	1	sci	sci	PROPN
admet-923	927	2	.	.	PROPN
admet-923	928	1	88	88	NUM
admet-923	928	2	(	(	PUNCT
admet-923	928	3	1999	1999	NUM
admet-923	928	4	)	)	PUNCT
admet-923	929	1	731–738	731–738	NUM
admet-923	929	2	.	.	PUNCT
admet-923	930	1	[	[	X
admet-923	930	2	47	47	NUM
admet-923	930	3	]	]	PUNCT
admet-923	930	4	k.	k.	PROPN
admet-923	930	5	sugano	sugano	PROPN
admet-923	930	6	.	.	PUNCT
admet-923	931	1	theoretical	theoretical	ADJ
admet-923	931	2	comparison	comparison	NOUN
admet-923	931	3	of	of	ADP
admet-923	931	4	hydrodynamic	hydrodynamic	ADJ
admet-923	931	5	diffusion	diffusion	NOUN
admet-923	931	6	layer	layer	NOUN
admet-923	931	7	models	model	NOUN
admet-923	931	8	used	use	VERB
admet-923	931	9	for	for	ADP
admet-923	931	10	dissolution	dissolution	ADJ
admet-923	931	11	simulation	simulation	NOUN
admet-923	931	12	in	in	ADP
admet-923	931	13	drug	drug	NOUN
admet-923	931	14	discovery	discovery	NOUN
admet-923	931	15	and	and	CCONJ
admet-923	931	16	development	development	NOUN
admet-923	931	17	.	.	PUNCT
admet-923	932	1	int	int	NOUN
admet-923	932	2	.	.	PUNCT
admet-923	933	1	j.	j.	PROPN
admet-923	933	2	pharm	pharm	PROPN
admet-923	933	3	.	.	PUNCT
admet-923	934	1	363	363	NUM
admet-923	934	2	(	(	PUNCT
admet-923	934	3	2008	2008	NUM
admet-923	934	4	)	)	PUNCT
admet-923	934	5	73–77	73–77	NOUN
admet-923	934	6	.	.	PUNCT
admet-923	935	1	[	[	X
admet-923	935	2	48	48	NUM
admet-923	935	3	]	]	SYM
admet-923	935	4	s.s	s.s	PROPN
admet-923	935	5	.	.	PROPN
admet-923	935	6	ozturk	ozturk	PROPN
admet-923	935	7	,	,	PUNCT
admet-923	935	8	b.o	b.o	PROPN
admet-923	935	9	.	.	PROPN
admet-923	935	10	palsson	palsson	PROPN
admet-923	935	11	,	,	PUNCT
admet-923	935	12	j.b	j.b	PROPN
admet-923	935	13	.	.	PROPN
admet-923	935	14	dressman	dressman	PROPN
admet-923	935	15	.	.	PUNCT
admet-923	936	1	dissolution	dissolution	PROPN
admet-923	936	2	of	of	ADP
admet-923	936	3	lonizable	lonizable	ADJ
admet-923	936	4	drugs	drug	NOUN
admet-923	936	5	in	in	ADP
admet-923	936	6	buffered	buffered	ADJ
admet-923	936	7	and	and	CCONJ
admet-923	936	8	unbuffered	unbuffered	ADJ
admet-923	936	9	solutions	solution	NOUN
admet-923	936	10	.	.	PUNCT
admet-923	937	1	pharm	pharm	NOUN
admet-923	937	2	.	.	PUNCT
admet-923	938	1	res	re	NOUN
admet-923	938	2	.	.	PROPN
admet-923	939	1	5	5	NUM
admet-923	939	2	(	(	PUNCT
admet-923	939	3	1988	1988	NUM
admet-923	939	4	)	)	PUNCT
admet-923	940	1	272–282	272–282	NUM
admet-923	940	2	.	.	PUNCT
admet-923	941	1	[	[	X
admet-923	941	2	49	49	NUM
admet-923	941	3	]	]	PUNCT
admet-923	941	4	k.	k.	PROPN
admet-923	941	5	sugano	sugano	PROPN
admet-923	941	6	.	.	PUNCT
admet-923	942	1	estimation	estimation	NOUN
admet-923	942	2	of	of	ADP
admet-923	942	3	effective	effective	ADJ
admet-923	942	4	intestinal	intestinal	ADJ
admet-923	942	5	membrane	membrane	NOUN
admet-923	942	6	permeability	permeability	NOUN
admet-923	942	7	considering	consider	VERB
admet-923	942	8	bile	bile	NOUN
admet-923	942	9	micelle	micelle	NOUN
admet-923	942	10	solubilisation	solubilisation	NOUN
admet-923	942	11	.	.	PUNCT
admet-923	943	1	int	int	NOUN
admet-923	943	2	.	.	PUNCT
admet-923	944	1	j.	j.	PROPN
admet-923	944	2	pharm	pharm	PROPN
admet-923	944	3	.	.	PUNCT
admet-923	945	1	368	368	NUM
admet-923	945	2	(	(	PUNCT
admet-923	945	3	2009	2009	NUM
admet-923	945	4	)	)	PUNCT
admet-923	945	5	116–122	116–122	NUM
admet-923	945	6	.	.	PUNCT
admet-923	946	1	[	[	X
admet-923	946	2	50	50	NUM
admet-923	946	3	]	]	X
admet-923	946	4	y.	y.	PROPN
admet-923	946	5	akiyama	akiyama	PROPN
admet-923	946	6	,	,	PUNCT
admet-923	946	7	t.	t.	PROPN
admet-923	946	8	kimoto	kimoto	PROPN
admet-923	946	9	,	,	PUNCT
admet-923	946	10	h.	h.	PROPN
admet-923	946	11	mukumoto	mukumoto	PROPN
admet-923	946	12	,	,	PUNCT
admet-923	946	13	s.	s.	PROPN
admet-923	946	14	miyake	miyake	PROPN
admet-923	946	15	,	,	PUNCT
admet-923	946	16	s.	s.	PROPN
admet-923	946	17	ito	ito	PROPN
admet-923	946	18	,	,	PUNCT
admet-923	946	19	t.	t.	PROPN
admet-923	946	20	taniguchi	taniguchi	PROPN
admet-923	946	21	,	,	PUNCT
admet-923	946	22	y.	y.	PROPN
admet-923	946	23	nomura	nomura	PROPN
admet-923	946	24	,	,	PUNCT
admet-923	946	25	n.	n.	PROPN
admet-923	946	26	matsumura	matsumura	ADV
admet-923	946	27	,	,	PUNCT
admet-923	946	28	t.	t.	PROPN
admet-923	946	29	fujita	fujita	PROPN
admet-923	946	30	,	,	PUNCT
admet-923	946	31	k.	k.	PROPN
admet-923	946	32	sugano	sugano	PROPN
admet-923	946	33	.	.	PUNCT
admet-923	946	34	prediction	prediction	NOUN
admet-923	946	35	accuracy	accuracy	NOUN
admet-923	946	36	of	of	ADP
admet-923	946	37	mechanism	mechanism	NOUN
admet-923	946	38	-	-	PUNCT
admet-923	946	39	based	base	VERB
admet-923	946	40	oral	oral	ADJ
admet-923	946	41	absorption	absorption	NOUN
admet-923	946	42	model	model	NOUN
admet-923	946	43	for	for	ADP
admet-923	946	44	dogs	dog	NOUN
admet-923	946	45	.	.	PUNCT
admet-923	947	1	j.	j.	PROPN
admet-923	947	2	pharm	pharm	PROPN
admet-923	947	3	.	.	PUNCT
admet-923	948	1	sci	sci	PROPN
admet-923	948	2	.	.	PROPN
admet-923	949	1	108	108	NUM
admet-923	949	2	(	(	PUNCT
admet-923	949	3	2019	2019	NUM
admet-923	949	4	)	)	PUNCT
admet-923	949	5	2728–2736	2728–2736	NUM
admet-923	949	6	.	.	PUNCT
admet-923	950	1	[	[	X
admet-923	950	2	51	51	NUM
admet-923	950	3	]	]	X
admet-923	950	4	y.	y.	PROPN
admet-923	950	5	akiyama	akiyama	PROPN
admet-923	950	6	,	,	PUNCT
admet-923	950	7	s.	s.	PROPN
admet-923	950	8	ito	ito	PROPN
admet-923	950	9	,	,	PUNCT
admet-923	950	10	t.	t.	PROPN
admet-923	950	11	fujita	fujita	PROPN
admet-923	950	12	,	,	PUNCT
admet-923	950	13	k.	k.	PROPN
admet-923	950	14	sugano	sugano	PROPN
admet-923	950	15	.	.	PUNCT
admet-923	951	1	prediction	prediction	NOUN
admet-923	951	2	of	of	ADP
admet-923	951	3	negative	negative	ADJ
admet-923	951	4	food	food	NOUN
admet-923	951	5	effect	effect	NOUN
admet-923	951	6	induced	induce	VERB
admet-923	951	7	by	by	ADP
admet-923	951	8	bile	bile	NOUN
admet-923	951	9	micelle	micelle	NOUN
admet-923	951	10	binding	bind	VERB
admet-923	951	11	on	on	ADP
admet-923	951	12	oral	oral	ADJ
admet-923	951	13	absorption	absorption	NOUN
admet-923	951	14	of	of	ADP
admet-923	951	15	hydrophilic	hydrophilic	ADJ
admet-923	951	16	cationic	cationic	ADJ
admet-923	951	17	drugs	drug	NOUN
admet-923	951	18	.	.	PUNCT
admet-923	952	1	eur	eur	PROPN
admet-923	952	2	.	.	PUNCT
admet-923	953	1	j.	j.	PROPN
admet-923	953	2	pharm	pharm	PROPN
admet-923	953	3	.	.	PUNCT
admet-923	954	1	sci	sci	PROPN
admet-923	954	2	.	.	PUNCT
admet-923	954	3	(	(	PUNCT
admet-923	954	4	2020	2020	NUM
admet-923	954	5	)	)	PUNCT
admet-923	954	6	105543	105543	NUM
admet-923	954	7	.	.	PUNCT
admet-923	955	1	[	[	X
admet-923	955	2	52	52	NUM
admet-923	955	3	]	]	PUNCT
admet-923	955	4	k.	k.	PROPN
admet-923	955	5	sugano	sugano	PROPN
admet-923	955	6	.	.	PUNCT
admet-923	956	1	theoretical	theoretical	ADJ
admet-923	956	2	investigation	investigation	NOUN
admet-923	956	3	of	of	ADP
admet-923	956	4	passive	passive	ADJ
admet-923	956	5	intestinal	intestinal	ADJ
admet-923	956	6	membrane	membrane	NOUN
admet-923	956	7	permeability	permeability	NOUN
admet-923	956	8	using	use	VERB
admet-923	956	9	monte	monte	PROPN
admet-923	956	10	carlo	carlo	PROPN
admet-923	956	11	method	method	NOUN
admet-923	956	12	to	to	PART
admet-923	956	13	generate	generate	VERB
admet-923	956	14	drug	drug	NOUN
admet-923	956	15	-	-	PUNCT
admet-923	956	16	like	like	ADJ
admet-923	956	17	molecule	molecule	NOUN
admet-923	956	18	population	population	NOUN
admet-923	956	19	.	.	PUNCT
admet-923	957	1	int	int	NOUN
admet-923	957	2	.	.	PUNCT
admet-923	958	1	j.	j.	PROPN
admet-923	958	2	pharm	pharm	PROPN
admet-923	958	3	.	.	PUNCT
admet-923	959	1	373	373	NUM
admet-923	959	2	(	(	PUNCT
admet-923	959	3	2009	2009	NUM
admet-923	959	4	)	)	PUNCT
admet-923	959	5	.	.	PUNCT
admet-923	960	1	[	[	X
admet-923	960	2	53	53	NUM
admet-923	960	3	]	]	PUNCT
admet-923	960	4	k.	k.	PROPN
admet-923	960	5	sugano	sugano	PROPN
admet-923	960	6	,	,	PUNCT
admet-923	960	7	m.	m.	NOUN
admet-923	960	8	kataoka	kataoka	PROPN
admet-923	960	9	,	,	PUNCT
admet-923	960	10	c.	c.	PROPN
admet-923	960	11	da	da	PROPN
admet-923	960	12	costa	costa	PROPN
admet-923	960	13	mathews	mathews	PROPN
admet-923	960	14	,	,	PUNCT
admet-923	960	15	s.	s.	PROPN
admet-923	960	16	yamashita	yamashita	PROPN
admet-923	960	17	.	.	PUNCT
admet-923	961	1	prediction	prediction	NOUN
admet-923	961	2	of	of	ADP
admet-923	961	3	food	food	NOUN
admet-923	961	4	effect	effect	NOUN
admet-923	961	5	by	by	ADP
admet-923	961	6	bile	bile	NOUN
admet-923	961	7	micelles	micelle	NOUN
admet-923	961	8	on	on	ADP
admet-923	961	9	oral	oral	ADJ
admet-923	961	10	drug	drug	NOUN
admet-923	961	11	absorption	absorption	NOUN
admet-923	961	12	considering	consider	VERB
admet-923	961	13	free	free	ADJ
admet-923	961	14	fraction	fraction	NOUN
admet-923	961	15	in	in	ADP
admet-923	961	16	intestinal	intestinal	ADJ
admet-923	961	17	fluid	fluid	NOUN
admet-923	961	18	.	.	PUNCT
admet-923	962	1	eur	eur	PROPN
admet-923	962	2	.	.	PUNCT
admet-923	963	1	j.	j.	PROPN
admet-923	963	2	pharm	pharm	PROPN
admet-923	963	3	.	.	PUNCT
admet-923	964	1	sci	sci	PROPN
admet-923	964	2	.	.	PROPN
admet-923	965	1	40	40	NUM
admet-923	965	2	(	(	PUNCT
admet-923	965	3	2010	2010	NUM
admet-923	965	4	)	)	PUNCT
admet-923	965	5	.	.	PUNCT
admet-923	966	1	[	[	X
admet-923	966	2	54	54	NUM
admet-923	966	3	]	]	PUNCT
admet-923	966	4	d.	d.	PROPN
admet-923	966	5	pade	pade	PROPN
admet-923	966	6	,	,	PUNCT
admet-923	966	7	m.	m.	NOUN
admet-923	966	8	jamei	jamei	PROPN
admet-923	966	9	,	,	PUNCT
admet-923	966	10	a.	a.	PROPN
admet-923	966	11	rostami	rostami	PROPN
admet-923	966	12	-	-	PUNCT
admet-923	966	13	hodjegan	hodjegan	PROPN
admet-923	966	14	,	,	PUNCT
admet-923	966	15	d.b	d.b	PROPN
admet-923	966	16	.	.	PROPN
admet-923	966	17	turner	turner	PROPN
admet-923	966	18	.	.	PUNCT
admet-923	967	1	application	application	NOUN
admet-923	967	2	of	of	ADP
admet-923	967	3	the	the	DET
admet-923	967	4	mechpeff	mechpeff	NOUN
admet-923	967	5	model	model	NOUN
admet-923	967	6	to	to	PART
admet-923	967	7	predict	predict	VERB
admet-923	967	8	passive	passive	ADJ
admet-923	967	9	effective	effective	ADJ
admet-923	967	10	intestinal	intestinal	ADJ
admet-923	967	11	permeability	permeability	NOUN
admet-923	967	12	in	in	ADP
admet-923	967	13	the	the	DET
admet-923	967	14	different	different	ADJ
admet-923	967	15	regions	region	NOUN
admet-923	967	16	of	of	ADP
admet-923	967	17	the	the	DET
admet-923	967	18	rodent	rodent	ADJ
admet-923	967	19	small	small	ADJ
admet-923	967	20	intestine	intestine	NOUN
admet-923	967	21	and	and	CCONJ
admet-923	967	22	colon	colon	NOUN
admet-923	967	23	.	.	PUNCT
admet-923	968	1	biopharm	biopharm	NOUN
admet-923	968	2	.	.	PUNCT
admet-923	969	1	drug	drug	PROPN
admet-923	969	2	dispos	dispos	PROPN
admet-923	969	3	.	.	PUNCT
admet-923	970	1	38	38	NUM
admet-923	970	2	(	(	PUNCT
admet-923	970	3	2017	2017	NUM
admet-923	970	4	)	)	PUNCT
admet-923	970	5	94–114	94–114	NUM
admet-923	970	6	.	.	PUNCT
admet-923	971	1	[	[	X
admet-923	971	2	55	55	NUM
admet-923	971	3	]	]	PUNCT
admet-923	971	4	k.	k.	PROPN
admet-923	971	5	sugano	sugano	PROPN
admet-923	971	6	.	.	PUNCT
admet-923	972	1	estimation	estimation	NOUN
admet-923	972	2	of	of	ADP
admet-923	972	3	effective	effective	ADJ
admet-923	972	4	intestinal	intestinal	ADJ
admet-923	972	5	membrane	membrane	NOUN
admet-923	972	6	permeability	permeability	NOUN
admet-923	972	7	considering	consider	VERB
admet-923	972	8	bile	bile	NOUN
admet-923	972	9	micelle	micelle	NOUN
admet-923	972	10	solubilisation	solubilisation	NOUN
admet-923	972	11	.	.	PUNCT
admet-923	973	1	int	int	NOUN
admet-923	973	2	.	.	PUNCT
admet-923	974	1	j.	j.	PROPN
admet-923	974	2	pharm	pharm	PROPN
admet-923	974	3	.	.	PUNCT
admet-923	975	1	368	368	NUM
admet-923	975	2	(	(	PUNCT
admet-923	975	3	2009	2009	NUM
admet-923	975	4	)	)	PUNCT
admet-923	975	5	.	.	PUNCT
admet-923	976	1	[	[	X
admet-923	976	2	56	56	NUM
admet-923	976	3	]	]	PUNCT
admet-923	976	4	a.	a.	NOUN
admet-923	976	5	dokoumetzidis	dokoumetzidis	PROPN
admet-923	976	6	,	,	PUNCT
admet-923	976	7	p.	p.	PROPN
admet-923	976	8	macheras	macheras	PROPN
admet-923	976	9	.	.	PUNCT
admet-923	977	1	a	a	DET
admet-923	977	2	century	century	NOUN
admet-923	977	3	of	of	ADP
admet-923	977	4	dissolution	dissolution	ADJ
admet-923	977	5	research	research	NOUN
admet-923	977	6	:	:	PUNCT
admet-923	977	7	from	from	ADP
admet-923	977	8	noyes	noyes	PROPN
admet-923	977	9	and	and	CCONJ
admet-923	977	10	whitney	whitney	PROPN
admet-923	977	11	to	to	ADP
admet-923	977	12	the	the	DET
admet-923	977	13	biopharmaceutics	biopharmaceutics	NOUN
admet-923	977	14	classification	classification	NOUN
admet-923	977	15	system	system	NOUN
admet-923	977	16	.	.	PUNCT
admet-923	978	1	int	int	NOUN
admet-923	978	2	.	.	PUNCT
admet-923	979	1	j.	j.	PROPN
admet-923	979	2	pharm	pharm	PROPN
admet-923	979	3	.	.	PUNCT
admet-923	980	1	321	321	NUM
admet-923	980	2	(	(	PUNCT
admet-923	980	3	2006	2006	NUM
admet-923	980	4	)	)	PUNCT
admet-923	980	5	1–11	1–11	PROPN
admet-923	980	6	.	.	PUNCT
admet-923	981	1	[	[	X
admet-923	981	2	57	57	NUM
admet-923	981	3	]	]	PUNCT
admet-923	981	4	m.	m.	NOUN
admet-923	981	5	jamei	jamei	PROPN
admet-923	981	6	,	,	PUNCT
admet-923	981	7	b.	b.	PROPN
admet-923	981	8	abrahamsson	abrahamsson	PROPN
admet-923	981	9	,	,	PUNCT
admet-923	981	10	j.	j.	PROPN
admet-923	981	11	brown	brown	PROPN
admet-923	981	12	,	,	PUNCT
admet-923	981	13	j.	j.	PROPN
admet-923	981	14	bevernage	bevernage	PROPN
admet-923	981	15	,	,	PUNCT
admet-923	981	16	m.b	m.b	PROPN
admet-923	981	17	.	.	PROPN
admet-923	981	18	bolger	bolger	PROPN
admet-923	981	19	,	,	PUNCT
admet-923	981	20	t.	t.	PROPN
admet-923	981	21	heimbach	heimbach	PROPN
admet-923	981	22	,	,	PUNCT
admet-923	981	23	e.	e.	PROPN
admet-923	981	24	karlsson	karlsson	PROPN
admet-923	981	25	,	,	PUNCT
admet-923	981	26	e.	e.	PROPN
admet-923	981	27	kotzagiorgis	kotzagiorgis	PROPN
admet-923	981	28	,	,	PUNCT
admet-923	981	29	a.	a.	PROPN
admet-923	981	30	lindahl	lindahl	PROPN
admet-923	981	31	,	,	PUNCT
admet-923	981	32	m.	m.	NOUN
admet-923	981	33	mcallister	mcallister	PROPN
admet-923	981	34	,	,	PUNCT
admet-923	981	35	others	other	NOUN
admet-923	981	36	.	.	PUNCT
admet-923	982	1	current	current	ADJ
admet-923	982	2	status	status	NOUN
admet-923	982	3	and	and	CCONJ
admet-923	982	4	future	future	ADJ
admet-923	982	5	opportunities	opportunity	NOUN
admet-923	982	6	for	for	ADP
admet-923	982	7	incorporation	incorporation	NOUN
admet-923	982	8	of	of	ADP
admet-923	982	9	dissolution	dissolution	ADJ
admet-923	982	10	data	datum	NOUN
admet-923	982	11	in	in	ADP
admet-923	982	12	pbpk	pbpk	NOUN
admet-923	982	13	modeling	modeling	NOUN
admet-923	982	14	for	for	ADP
admet-923	982	15	pharmaceutical	pharmaceutical	NOUN
admet-923	982	16	development	development	NOUN
admet-923	982	17	and	and	CCONJ
admet-923	982	18	regulatory	regulatory	ADJ
admet-923	982	19	applications	application	NOUN
admet-923	982	20	:	:	PUNCT
admet-923	982	21	orbito	orbito	ADJ
admet-923	982	22	consortium	consortium	PROPN
admet-923	982	23	commentary	commentary	NOUN
admet-923	982	24	.	.	PUNCT
admet-923	983	1	eur	eur	PROPN
admet-923	983	2	.	.	PUNCT
admet-923	984	1	j.	j.	PROPN
admet-923	984	2	pharm	pharm	PROPN
admet-923	984	3	.	.	PUNCT
admet-923	985	1	biopharm	biopharm	PROPN
admet-923	985	2	.	.	PUNCT
admet-923	986	1	155	155	NUM
admet-923	986	2	(	(	PUNCT
admet-923	986	3	2020	2020	NUM
admet-923	986	4	)	)	PUNCT
admet-923	986	5	55–68	55–68	NUM
admet-923	986	6	.	.	PUNCT
admet-923	987	1	https://doi.org/10.5599/admet.923	https://doi.org/10.5599/admet.923	X
admet-923	987	2	kiyohiko	kiyohiko	PROPN
admet-923	987	3	sugano	sugano	PROPN
admet-923	987	4	admet	admet	PROPN
admet-923	987	5	&	&	CCONJ
admet-923	987	6	dmpk	dmpk	PROPN
admet-923	987	7	9(2	9(2	NUM
admet-923	987	8	)	)	PUNCT
admet-923	987	9	(	(	PUNCT
admet-923	987	10	2021	2021	NUM
admet-923	987	11	)	)	PUNCT
admet-923	987	12	75	75	NUM
admet-923	987	13	-	-	SYM
admet-923	987	14	109	109	NUM
admet-923	987	15	102	102	NUM
admet-923	987	16	[	[	X
admet-923	987	17	58	58	NUM
admet-923	987	18	]	]	PUNCT
admet-923	987	19	m.	m.	NOUN
admet-923	987	20	mcallister	mcallister	PROPN
admet-923	987	21	.	.	PUNCT
admet-923	988	1	dynamic	dynamic	ADJ
admet-923	988	2	dissolution	dissolution	NOUN
admet-923	988	3	:	:	PUNCT
admet-923	988	4	a	a	DET
admet-923	988	5	step	step	NOUN
admet-923	988	6	closer	close	ADV
admet-923	988	7	to	to	ADP
admet-923	988	8	predictive	predictive	ADJ
admet-923	988	9	dissolution	dissolution	NOUN
admet-923	988	10	testing	testing	NOUN
admet-923	988	11	?	?	PUNCT
admet-923	989	1	mol	mol	PROPN
admet-923	989	2	.	.	PUNCT
admet-923	989	3	pharm	pharm	PROPN
admet-923	989	4	.	.	PUNCT
admet-923	990	1	7	7	NUM
admet-923	990	2	(	(	PUNCT
admet-923	990	3	2010	2010	NUM
admet-923	990	4	)	)	PUNCT
admet-923	990	5	1374–1387	1374–1387	NUM
admet-923	990	6	.	.	PUNCT
admet-923	991	1	[	[	X
admet-923	991	2	59	59	NUM
admet-923	991	3	]	]	SYM
admet-923	991	4	b.j	b.j	PROPN
admet-923	991	5	.	.	PROPN
admet-923	991	6	krieg	krieg	PROPN
admet-923	991	7	,	,	PUNCT
admet-923	991	8	s.m	s.m	PROPN
admet-923	991	9	.	.	PROPN
admet-923	991	10	taghavi	taghavi	PROPN
admet-923	991	11	,	,	PUNCT
admet-923	991	12	g.l	g.l	PROPN
admet-923	991	13	.	.	PROPN
admet-923	991	14	amidon	amidon	PROPN
admet-923	991	15	,	,	PUNCT
admet-923	991	16	g.e	g.e	PROPN
admet-923	991	17	.	.	PROPN
admet-923	991	18	amidon	amidon	PROPN
admet-923	991	19	.	.	PUNCT
admet-923	992	1	in	in	ADP
admet-923	992	2	vivo	vivo	ADJ
admet-923	992	3	predictive	predictive	ADJ
admet-923	992	4	dissolution	dissolution	NOUN
admet-923	992	5	:	:	PUNCT
admet-923	992	6	transport	transport	VERB
admet-923	992	7	analysis	analysis	NOUN
admet-923	992	8	of	of	ADP
admet-923	992	9	the	the	DET
admet-923	992	10	co2	co2	NOUN
admet-923	992	11	,	,	PUNCT
admet-923	992	12	bicarbonate	bicarbonate	VERB
admet-923	992	13	in	in	ADP
admet-923	992	14	vivo	vivo	ADJ
admet-923	992	15	buffer	buffer	NOUN
admet-923	992	16	system	system	NOUN
admet-923	992	17	.	.	PUNCT
admet-923	993	1	j.	j.	PROPN
admet-923	993	2	pharm	pharm	PROPN
admet-923	993	3	.	.	PUNCT
admet-923	994	1	sci	sci	PROPN
admet-923	994	2	.	.	PROPN
admet-923	994	3	103	103	NUM
admet-923	994	4	(	(	PUNCT
admet-923	994	5	2014	2014	NUM
admet-923	994	6	)	)	PUNCT
admet-923	994	7	3473–3490	3473–3490	NUM
admet-923	994	8	.	.	PUNCT
admet-923	995	1	[	[	X
admet-923	995	2	60	60	NUM
admet-923	995	3	]	]	X
admet-923	995	4	h.	h.	PROPN
admet-923	995	5	lennernäs	lennernäs	PROPN
admet-923	995	6	,	,	PUNCT
admet-923	995	7	a.	a.	PROPN
admet-923	995	8	lindahl	lindahl	PROPN
admet-923	995	9	,	,	PUNCT
admet-923	995	10	a.	a.	PROPN
admet-923	995	11	van	van	PROPN
admet-923	995	12	peer	peer	NOUN
admet-923	995	13	,	,	PUNCT
admet-923	995	14	c.	c.	PROPN
admet-923	995	15	ollier	ollier	PROPN
admet-923	995	16	,	,	PUNCT
admet-923	995	17	t.	t.	PROPN
admet-923	995	18	flanagan	flanagan	PROPN
admet-923	995	19	,	,	PUNCT
admet-923	995	20	r.	r.	PROPN
admet-923	995	21	lionberger	lionberger	PROPN
admet-923	995	22	,	,	PUNCT
admet-923	995	23	a.	a.	NOUN
admet-923	995	24	nordmark	nordmark	PROPN
admet-923	995	25	,	,	PUNCT
admet-923	995	26	s.	s.	PROPN
admet-923	995	27	yamashita	yamashita	PROPN
admet-923	995	28	,	,	PUNCT
admet-923	995	29	l.	l.	PROPN
admet-923	995	30	yu	yu	PROPN
admet-923	995	31	,	,	PUNCT
admet-923	995	32	g.l	g.l	PROPN
admet-923	995	33	.	.	PROPN
admet-923	995	34	amidon	amidon	PROPN
admet-923	995	35	,	,	PUNCT
admet-923	995	36	v.	v.	PROPN
admet-923	995	37	fischer	fischer	PROPN
admet-923	995	38	,	,	PUNCT
admet-923	995	39	e.	e.	PROPN
admet-923	995	40	sjögren	sjögren	PROPN
admet-923	995	41	,	,	PUNCT
admet-923	995	42	p.	p.	PROPN
admet-923	995	43	zane	zane	PROPN
admet-923	995	44	,	,	PUNCT
admet-923	995	45	m.	m.	NOUN
admet-923	995	46	mcallister	mcallister	PROPN
admet-923	995	47	,	,	PUNCT
admet-923	995	48	b.	b.	PROPN
admet-923	995	49	abrahamsson	abrahamsson	PROPN
admet-923	995	50	.	.	PUNCT
admet-923	996	1	in	in	ADP
admet-923	996	2	vivo	vivo	ADJ
admet-923	996	3	predictive	predictive	ADJ
admet-923	996	4	dissolution	dissolution	NOUN
admet-923	996	5	(	(	PUNCT
admet-923	996	6	ipd	ipd	PROPN
admet-923	996	7	)	)	PUNCT
admet-923	996	8	and	and	CCONJ
admet-923	996	9	biopharmaceutical	biopharmaceutical	NOUN
admet-923	996	10	modeling	modeling	NOUN
admet-923	996	11	and	and	CCONJ
admet-923	996	12	simulation	simulation	NOUN
admet-923	996	13	:	:	PUNCT
admet-923	996	14	future	future	ADJ
admet-923	996	15	use	use	NOUN
admet-923	996	16	of	of	ADP
admet-923	996	17	modern	modern	ADJ
admet-923	996	18	approaches	approach	NOUN
admet-923	996	19	and	and	CCONJ
admet-923	996	20	methodologies	methodology	NOUN
admet-923	996	21	in	in	ADP
admet-923	996	22	a	a	DET
admet-923	996	23	regulatory	regulatory	ADJ
admet-923	996	24	context	context	NOUN
admet-923	996	25	.	.	PUNCT
admet-923	997	1	mol	mol	PROPN
admet-923	997	2	.	.	PUNCT
admet-923	997	3	pharm	pharm	PROPN
admet-923	997	4	.	.	PUNCT
admet-923	998	1	14	14	NUM
admet-923	998	2	(	(	PUNCT
admet-923	998	3	2017	2017	NUM
admet-923	998	4	)	)	PUNCT
admet-923	998	5	1307–1314	1307–1314	NUM
admet-923	998	6	.	.	PUNCT
admet-923	999	1	[	[	X
admet-923	999	2	61	61	NUM
admet-923	999	3	]	]	X
admet-923	999	4	b.j	b.j	PROPN
admet-923	999	5	.	.	PROPN
admet-923	999	6	krieg	krieg	PROPN
admet-923	999	7	,	,	PUNCT
admet-923	999	8	s.m	s.m	PROPN
admet-923	999	9	.	.	PROPN
admet-923	999	10	taghavi	taghavi	PROPN
admet-923	999	11	,	,	PUNCT
admet-923	999	12	g.l	g.l	PROPN
admet-923	999	13	.	.	PROPN
admet-923	999	14	amidon	amidon	PROPN
admet-923	999	15	,	,	PUNCT
admet-923	999	16	g.e	g.e	PROPN
admet-923	999	17	.	.	PROPN
admet-923	999	18	amidon	amidon	PROPN
admet-923	999	19	.	.	PUNCT
admet-923	1000	1	in	in	ADP
admet-923	1000	2	vivo	vivo	ADJ
admet-923	1000	3	predictive	predictive	ADJ
admet-923	1000	4	dissolution	dissolution	NOUN
admet-923	1000	5	:	:	PUNCT
admet-923	1000	6	comparing	compare	VERB
admet-923	1000	7	the	the	DET
admet-923	1000	8	effect	effect	NOUN
admet-923	1000	9	of	of	ADP
admet-923	1000	10	bicarbonate	bicarbonate	NOUN
admet-923	1000	11	and	and	CCONJ
admet-923	1000	12	phosphate	phosphate	ADJ
admet-923	1000	13	buffer	buffer	NOUN
admet-923	1000	14	on	on	ADP
admet-923	1000	15	the	the	DET
admet-923	1000	16	dissolution	dissolution	NOUN
admet-923	1000	17	of	of	ADP
admet-923	1000	18	weak	weak	ADJ
admet-923	1000	19	acids	acid	NOUN
admet-923	1000	20	and	and	CCONJ
admet-923	1000	21	weak	weak	ADJ
admet-923	1000	22	bases	basis	NOUN
admet-923	1000	23	.	.	PUNCT
admet-923	1001	1	j.	j.	PROPN
admet-923	1001	2	pharm	pharm	PROPN
admet-923	1001	3	.	.	PUNCT
admet-923	1002	1	sci	sci	PROPN
admet-923	1002	2	.	.	PROPN
admet-923	1003	1	104	104	NUM
admet-923	1003	2	(	(	PUNCT
admet-923	1003	3	2015	2015	NUM
admet-923	1003	4	)	)	PUNCT
admet-923	1003	5	2894–2904	2894–2904	NUM
admet-923	1003	6	.	.	PUNCT
admet-923	1004	1	[	[	X
admet-923	1004	2	62	62	NUM
admet-923	1004	3	]	]	X
admet-923	1004	4	g.	g.	PROPN
admet-923	1004	5	shmueli	shmueli	PROPN
admet-923	1004	6	,	,	PUNCT
admet-923	1004	7	others	other	NOUN
admet-923	1004	8	.	.	PUNCT
admet-923	1005	1	to	to	PART
admet-923	1005	2	explain	explain	VERB
admet-923	1005	3	or	or	CCONJ
admet-923	1005	4	to	to	PART
admet-923	1005	5	predict	predict	VERB
admet-923	1005	6	?	?	PUNCT
admet-923	1006	1	stat	stat	PROPN
admet-923	1006	2	.	.	PUNCT
admet-923	1007	1	sci	sci	PROPN
admet-923	1007	2	.	.	PROPN
admet-923	1008	1	25	25	NUM
admet-923	1008	2	(	(	PUNCT
admet-923	1008	3	2010	2010	NUM
admet-923	1008	4	)	)	PUNCT
admet-923	1009	1	289–310	289–310	NUM
admet-923	1009	2	.	.	PUNCT
admet-923	1010	1	[	[	X
admet-923	1010	2	63	63	NUM
admet-923	1010	3	]	]	PUNCT
admet-923	1010	4	m.	m.	PROPN
admet-923	1010	5	weisberg	weisberg	PROPN
admet-923	1010	6	.	.	PUNCT
admet-923	1010	7	simulation	simulation	NOUN
admet-923	1010	8	and	and	CCONJ
admet-923	1010	9	similarity	similarity	NOUN
admet-923	1010	10	:	:	PUNCT
admet-923	1010	11	using	use	VERB
admet-923	1010	12	models	model	NOUN
admet-923	1010	13	to	to	PART
admet-923	1010	14	understand	understand	VERB
admet-923	1010	15	the	the	DET
admet-923	1010	16	world	world	NOUN
admet-923	1010	17	,	,	PUNCT
admet-923	1010	18	oup	oup	PROPN
admet-923	1010	19	usa	usa	PROPN
admet-923	1010	20	,	,	PUNCT
admet-923	1010	21	2013	2013	NUM
admet-923	1010	22	.	.	PUNCT
admet-923	1011	1	https://books.google.co.jp/books?id=rdu5e532mioc	https://books.google.co.jp/books?id=rdu5e532mioc	NOUN
admet-923	1011	2	.	.	PUNCT
admet-923	1012	1	[	[	X
admet-923	1012	2	64	64	NUM
admet-923	1012	3	]	]	PUNCT
admet-923	1012	4	m.	m.	PROPN
admet-923	1012	5	weisberg	weisberg	PROPN
admet-923	1012	6	.	.	PUNCT
admet-923	1012	7	simulation	simulation	NOUN
admet-923	1012	8	and	and	CCONJ
admet-923	1012	9	similarity	similarity	NOUN
admet-923	1012	10	:	:	PUNCT
admet-923	1012	11	using	use	VERB
admet-923	1012	12	models	model	NOUN
admet-923	1012	13	to	to	PART
admet-923	1012	14	understand	understand	VERB
admet-923	1012	15	the	the	DET
admet-923	1012	16	world	world	NOUN
admet-923	1012	17	,	,	PUNCT
admet-923	1012	18	oup	oup	PROPN
admet-923	1012	19	usa	usa	PROPN
admet-923	1012	20	,	,	PUNCT
admet-923	1012	21	2013	2013	NUM
admet-923	1012	22	.	.	PUNCT
admet-923	1013	1	[	[	X
admet-923	1013	2	65	65	NUM
admet-923	1013	3	]	]	X
admet-923	1013	4	d.	d.	NOUN
admet-923	1013	5	orrell	orrell	PROPN
admet-923	1013	6	.	.	PUNCT
admet-923	1014	1	apollo	apollo	PROPN
admet-923	1014	2	’s	’s	PART
admet-923	1014	3	arrow	arrow	NOUN
admet-923	1014	4	,	,	PUNCT
admet-923	1014	5	harpercollins	harpercollin	NOUN
admet-923	1014	6	,	,	PUNCT
admet-923	1014	7	2008	2008	NUM
admet-923	1014	8	.	.	PUNCT
admet-923	1015	1	https://books.google.co.jp/books?id=snmphwaacaaj	https://books.google.co.jp/books?id=snmphwaacaaj	PROPN
admet-923	1015	2	.	.	PUNCT
admet-923	1016	1	[	[	X
admet-923	1016	2	66	66	NUM
admet-923	1016	3	]	]	PUNCT
admet-923	1016	4	a.	a.	NOUN
admet-923	1016	5	hisaka	hisaka	PROPN
admet-923	1016	6	,	,	PUNCT
admet-923	1016	7	y.	y.	PROPN
admet-923	1016	8	ohno	ohno	PROPN
admet-923	1016	9	,	,	PUNCT
admet-923	1016	10	t.	t.	PROPN
admet-923	1016	11	yamamoto	yamamoto	PROPN
admet-923	1016	12	,	,	PUNCT
admet-923	1016	13	h.	h.	PROPN
admet-923	1016	14	suzuki	suzuki	PROPN
admet-923	1016	15	.	.	PUNCT
admet-923	1017	1	theoretical	theoretical	ADJ
admet-923	1017	2	considerations	consideration	NOUN
admet-923	1017	3	on	on	ADP
admet-923	1017	4	quantitative	quantitative	ADJ
admet-923	1017	5	prediction	prediction	NOUN
admet-923	1017	6	of	of	ADP
admet-923	1017	7	drug	drug	NOUN
admet-923	1017	8	-	-	PUNCT
admet-923	1017	9	drug	drug	NOUN
admet-923	1017	10	interactions	interaction	NOUN
admet-923	1017	11	.	.	PUNCT
admet-923	1018	1	drug	drug	NOUN
admet-923	1018	2	metab	metab	PROPN
admet-923	1018	3	.	.	PUNCT
admet-923	1019	1	pharmacokinet	pharmacokinet	NOUN
admet-923	1019	2	.	.	PUNCT
admet-923	1020	1	25	25	NUM
admet-923	1020	2	(	(	PUNCT
admet-923	1020	3	2010	2010	NUM
admet-923	1020	4	)	)	PUNCT
admet-923	1020	5	48–61	48–61	PROPN
admet-923	1020	6	.	.	PUNCT
admet-923	1021	1	[	[	X
admet-923	1021	2	67	67	NUM
admet-923	1021	3	]	]	X
admet-923	1021	4	m.	m.	NOUN
admet-923	1021	5	tod	tod	PROPN
admet-923	1021	6	,	,	PUNCT
admet-923	1021	7	p.b	p.b	PROPN
admet-923	1021	8	.	.	PROPN
admet-923	1021	9	pierrillas	pierrillas	PROPN
admet-923	1021	10	,	,	PUNCT
admet-923	1021	11	l.	l.	PROPN
admet-923	1021	12	bourguignon	bourguignon	PROPN
admet-923	1021	13	,	,	PUNCT
admet-923	1021	14	s.	s.	PROPN
admet-923	1021	15	goutelle	goutelle	PROPN
admet-923	1021	16	.	.	PUNCT
admet-923	1022	1	comparison	comparison	NOUN
admet-923	1022	2	of	of	ADP
admet-923	1022	3	the	the	DET
admet-923	1022	4	static	static	NOUN
admet-923	1022	5	in	in	ADP
admet-923	1022	6	vivo	vivo	ADJ
admet-923	1022	7	approach	approach	NOUN
admet-923	1022	8	to	to	ADP
admet-923	1022	9	a	a	DET
admet-923	1022	10	physiologically	physiologically	ADV
admet-923	1022	11	based	base	VERB
admet-923	1022	12	pharmacokinetic	pharmacokinetic	ADJ
admet-923	1022	13	approach	approach	NOUN
admet-923	1022	14	for	for	ADP
admet-923	1022	15	metabolic	metabolic	NOUN
admet-923	1022	16	drug	drug	NOUN
admet-923	1022	17	--	--	PUNCT
admet-923	1022	18	drug	drug	NOUN
admet-923	1022	19	interactions	interaction	NOUN
admet-923	1022	20	prediction	prediction	NOUN
admet-923	1022	21	.	.	PUNCT
admet-923	1023	1	int	int	NOUN
admet-923	1023	2	.	.	PUNCT
admet-923	1024	1	j.	j.	PROPN
admet-923	1024	2	pharmacokinet	pharmacokinet	PROPN
admet-923	1024	3	.	.	PROPN
admet-923	1025	1	1	1	NUM
admet-923	1025	2	(	(	PUNCT
admet-923	1025	3	2016	2016	NUM
admet-923	1025	4	)	)	PUNCT
admet-923	1025	5	25–34	25–34	NUM
admet-923	1025	6	.	.	PUNCT
admet-923	1026	1	[	[	X
admet-923	1026	2	68	68	NUM
admet-923	1026	3	]	]	X
admet-923	1026	4	e.i	e.i	PROPN
admet-923	1026	5	.	.	PROPN
admet-923	1026	6	ette	ette	PROPN
admet-923	1026	7	,	,	PUNCT
admet-923	1026	8	p.j	p.j	PROPN
admet-923	1026	9	.	.	PROPN
admet-923	1026	10	williams	williams	PROPN
admet-923	1026	11	,	,	PUNCT
admet-923	1026	12	e.i	e.i	PROPN
admet-923	1026	13	.	.	PROPN
admet-923	1026	14	ette	ette	PROPN
admet-923	1026	15	,	,	PUNCT
admet-923	1026	16	p.j	p.j	PROPN
admet-923	1026	17	.	.	PROPN
admet-923	1026	18	williams	williams	PROPN
admet-923	1026	19	.	.	PUNCT
admet-923	1027	1	pharmacometrics	pharmacometric	NOUN
admet-923	1027	2	 	 	SPACE
admet-923	1027	3	:	:	PUNCT
admet-923	1027	4	the	the	DET
admet-923	1027	5	science	science	NOUN
admet-923	1027	6	of	of	ADP
admet-923	1027	7	quantitative	quantitative	ADJ
admet-923	1027	8	pharmacology	pharmacology	NOUN
admet-923	1027	9	/	/	PUNCT
admet-923	1027	10	edited	edit	VERB
admet-923	1027	11	by	by	ADP
admet-923	1027	12	ene	ene	PROPN
admet-923	1027	13	i.	i.	PROPN
admet-923	1027	14	ette	ette	PROPN
admet-923	1027	15	,	,	PUNCT
admet-923	1027	16	anoixis	anoixis	PROPN
admet-923	1027	17	corporation	corporation	NOUN
admet-923	1027	18	,	,	PUNCT
admet-923	1027	19	paul	paul	PROPN
admet-923	1027	20	j.	j.	PROPN
admet-923	1027	21	williams	williams	PROPN
admet-923	1027	22	,	,	PUNCT
admet-923	1027	23	university	university	PROPN
admet-923	1027	24	of	of	ADP
admet-923	1027	25	the	the	DET
admet-923	1027	26	pacific	pacific	PROPN
admet-923	1027	27	and	and	CCONJ
admet-923	1027	28	anoixis	anoixis	ADJ
admet-923	1027	29	corporation	corporation	NOUN
admet-923	1027	30	.	.	PUNCT
admet-923	1027	31	,	,	PUNCT
admet-923	1027	32	wiley	wiley	NOUN
admet-923	1027	33	-	-	PUNCT
admet-923	1027	34	interscience	interscience	PROPN
admet-923	1027	35	,	,	PUNCT
admet-923	1027	36	hoboken	hoboken	PROPN
admet-923	1027	37	,	,	PUNCT
admet-923	1027	38	new	new	PROPN
admet-923	1027	39	jersey	jersey	PROPN
admet-923	1027	40	,	,	PUNCT
admet-923	1027	41	2007	2007	NUM
admet-923	1027	42	.	.	PUNCT
admet-923	1028	1	[	[	X
admet-923	1028	2	69	69	NUM
admet-923	1028	3	]	]	PUNCT
admet-923	1028	4	k.	k.	PROPN
admet-923	1028	5	yamaoka	yamaoka	PROPN
admet-923	1028	6	,	,	PUNCT
admet-923	1028	7	t.	t.	PROPN
admet-923	1028	8	nakagawa	nakagawa	PROPN
admet-923	1028	9	,	,	PUNCT
admet-923	1028	10	t.	t.	PROPN
admet-923	1028	11	uno	uno	PROPN
admet-923	1028	12	.	.	PUNCT
admet-923	1029	1	application	application	NOUN
admet-923	1029	2	of	of	ADP
admet-923	1029	3	akaike	akaike	PROPN
admet-923	1029	4	’s	’s	PART
admet-923	1029	5	information	information	NOUN
admet-923	1029	6	criterion	criterion	NOUN
admet-923	1029	7	(	(	PUNCT
admet-923	1029	8	aic	aic	PROPN
admet-923	1029	9	)	)	PUNCT
admet-923	1029	10	in	in	ADP
admet-923	1029	11	the	the	DET
admet-923	1029	12	evaluation	evaluation	NOUN
admet-923	1029	13	of	of	ADP
admet-923	1029	14	linear	linear	ADJ
admet-923	1029	15	pharmacokinetic	pharmacokinetic	ADJ
admet-923	1029	16	equations	equation	NOUN
admet-923	1029	17	.	.	PUNCT
admet-923	1030	1	j.	j.	PROPN
admet-923	1030	2	pharmacokinet	pharmacokinet	PROPN
admet-923	1030	3	.	.	PUNCT
admet-923	1031	1	biopharm	biopharm	PROPN
admet-923	1031	2	.	.	PUNCT
admet-923	1032	1	6	6	NUM
admet-923	1032	2	(	(	PUNCT
admet-923	1032	3	1978	1978	NUM
admet-923	1032	4	)	)	PUNCT
admet-923	1033	1	165–175	165–175	NUM
admet-923	1033	2	.	.	PUNCT
admet-923	1034	1	[	[	X
admet-923	1034	2	70	70	NUM
admet-923	1034	3	]	]	X
admet-923	1034	4	r.	r.	PROPN
admet-923	1034	5	takano	takano	PROPN
admet-923	1034	6	,	,	PUNCT
admet-923	1034	7	k.	k.	PROPN
admet-923	1034	8	furumoto	furumoto	PROPN
admet-923	1034	9	,	,	PUNCT
admet-923	1034	10	k.	k.	PROPN
admet-923	1034	11	shiraki	shiraki	PROPN
admet-923	1034	12	,	,	PUNCT
admet-923	1034	13	n.	n.	NOUN
admet-923	1034	14	takata	takata	NOUN
admet-923	1034	15	,	,	PUNCT
admet-923	1034	16	y.	y.	PROPN
admet-923	1034	17	hayashi	hayashi	PROPN
admet-923	1034	18	,	,	PUNCT
admet-923	1034	19	y.	y.	PROPN
admet-923	1034	20	aso	aso	PROPN
admet-923	1034	21	,	,	PUNCT
admet-923	1034	22	s.	s.	PROPN
admet-923	1034	23	yamashita	yamashita	PROPN
admet-923	1034	24	.	.	PUNCT
admet-923	1035	1	rate	rate	NOUN
admet-923	1035	2	-	-	PUNCT
admet-923	1035	3	limiting	limit	VERB
admet-923	1035	4	steps	step	NOUN
admet-923	1035	5	of	of	ADP
admet-923	1035	6	oral	oral	ADJ
admet-923	1035	7	absorption	absorption	NOUN
admet-923	1035	8	for	for	ADP
admet-923	1035	9	poorly	poorly	ADV
admet-923	1035	10	water	water	NOUN
admet-923	1035	11	-	-	PUNCT
admet-923	1035	12	soluble	soluble	ADJ
admet-923	1035	13	drugs	drug	NOUN
admet-923	1035	14	in	in	ADP
admet-923	1035	15	dogs	dog	NOUN
admet-923	1035	16	;	;	PUNCT
admet-923	1035	17	prediction	prediction	NOUN
admet-923	1035	18	from	from	ADP
admet-923	1035	19	a	a	DET
admet-923	1035	20	miniscale	miniscale	NOUN
admet-923	1035	21	dissolution	dissolution	NOUN
admet-923	1035	22	test	test	NOUN
admet-923	1035	23	and	and	CCONJ
admet-923	1035	24	a	a	DET
admet-923	1035	25	physiologically	physiologically	ADV
admet-923	1035	26	-	-	PUNCT
admet-923	1035	27	based	base	VERB
admet-923	1035	28	computer	computer	NOUN
admet-923	1035	29	simulation	simulation	NOUN
admet-923	1035	30	.	.	PUNCT
admet-923	1036	1	pharm	pharm	PROPN
admet-923	1036	2	.	.	PUNCT
admet-923	1037	1	res	re	NOUN
admet-923	1037	2	.	.	PROPN
admet-923	1038	1	25	25	NUM
admet-923	1038	2	(	(	PUNCT
admet-923	1038	3	2008	2008	NUM
admet-923	1038	4	)	)	PUNCT
admet-923	1038	5	2334–2344	2334–2344	NUM
admet-923	1038	6	.	.	PUNCT
admet-923	1039	1	[	[	X
admet-923	1039	2	71	71	NUM
admet-923	1039	3	]	]	X
admet-923	1039	4	l.x	l.x	PROPN
admet-923	1039	5	.	.	PROPN
admet-923	1039	6	yu	yu	PROPN
admet-923	1039	7	.	.	PUNCT
admet-923	1040	1	an	an	DET
admet-923	1040	2	integrated	integrate	VERB
admet-923	1040	3	model	model	NOUN
admet-923	1040	4	for	for	ADP
admet-923	1040	5	determining	determine	VERB
admet-923	1040	6	causes	cause	NOUN
admet-923	1040	7	of	of	ADP
admet-923	1040	8	poor	poor	ADJ
admet-923	1040	9	oral	oral	ADJ
admet-923	1040	10	drug	drug	NOUN
admet-923	1040	11	absorption	absorption	NOUN
admet-923	1040	12	.	.	PUNCT
admet-923	1041	1	pharm	pharm	NOUN
admet-923	1041	2	.	.	PUNCT
admet-923	1042	1	res	re	NOUN
admet-923	1042	2	.	.	PUNCT
admet-923	1043	1	16	16	NUM
admet-923	1043	2	(	(	PUNCT
admet-923	1043	3	1999	1999	NUM
admet-923	1043	4	)	)	PUNCT
admet-923	1043	5	1883–1887	1883–1887	NUM
admet-923	1043	6	.	.	PUNCT
admet-923	1044	1	[	[	X
admet-923	1044	2	72	72	NUM
admet-923	1044	3	]	]	PUNCT
admet-923	1044	4	k.	k.	PROPN
admet-923	1044	5	sugano	sugano	PROPN
admet-923	1044	6	,	,	PUNCT
admet-923	1044	7	k.	k.	PROPN
admet-923	1044	8	terada	terada	PROPN
admet-923	1044	9	.	.	PUNCT
admet-923	1045	1	rateand	rateand	NOUN
admet-923	1045	2	extent	extent	NOUN
admet-923	1045	3	-	-	PUNCT
admet-923	1045	4	limiting	limit	VERB
admet-923	1045	5	factors	factor	NOUN
admet-923	1045	6	of	of	ADP
admet-923	1045	7	oral	oral	ADJ
admet-923	1045	8	drug	drug	NOUN
admet-923	1045	9	absorption	absorption	NOUN
admet-923	1045	10	:	:	PUNCT
admet-923	1045	11	theory	theory	NOUN
admet-923	1045	12	and	and	CCONJ
admet-923	1045	13	applications	application	NOUN
admet-923	1045	14	.	.	PUNCT
admet-923	1046	1	j.	j.	PROPN
admet-923	1046	2	pharm	pharm	PROPN
admet-923	1046	3	.	.	PUNCT
admet-923	1047	1	sci	sci	PROPN
admet-923	1047	2	.	.	PROPN
admet-923	1048	1	104	104	NUM
admet-923	1048	2	(	(	PUNCT
admet-923	1048	3	2015	2015	NUM
admet-923	1048	4	)	)	PUNCT
admet-923	1048	5	.	.	PUNCT
admet-923	1049	1	[	[	X
admet-923	1049	2	73	73	NUM
admet-923	1049	3	]	]	PUNCT
admet-923	1049	4	k.	k.	PROPN
admet-923	1049	5	sugano	sugano	PROPN
admet-923	1049	6	,	,	PUNCT
admet-923	1049	7	y.	y.	PROPN
admet-923	1049	8	nabuchi	nabuchi	PROPN
admet-923	1049	9	,	,	PUNCT
admet-923	1049	10	m.	m.	PROPN
admet-923	1049	11	machida	machida	PROPN
admet-923	1049	12	,	,	PUNCT
admet-923	1049	13	y.	y.	PROPN
admet-923	1049	14	aso	aso	PROPN
admet-923	1049	15	.	.	PUNCT
admet-923	1050	1	prediction	prediction	NOUN
admet-923	1050	2	of	of	ADP
admet-923	1050	3	human	human	ADJ
admet-923	1050	4	intestinal	intestinal	ADJ
admet-923	1050	5	permeability	permeability	NOUN
admet-923	1050	6	using	use	VERB
admet-923	1050	7	artificial	artificial	ADJ
admet-923	1050	8	membrane	membrane	NOUN
admet-923	1050	9	permeability	permeability	NOUN
admet-923	1050	10	.	.	PUNCT
admet-923	1051	1	int	int	NOUN
admet-923	1051	2	.	.	PUNCT
admet-923	1052	1	j.	j.	PROPN
admet-923	1052	2	pharm	pharm	PROPN
admet-923	1052	3	.	.	PUNCT
admet-923	1053	1	257	257	NUM
admet-923	1053	2	(	(	PUNCT
admet-923	1053	3	2003	2003	NUM
admet-923	1053	4	)	)	PUNCT
admet-923	1053	5	.	.	PUNCT
admet-923	1054	1	[	[	X
admet-923	1054	2	74	74	NUM
admet-923	1054	3	]	]	PUNCT
admet-923	1054	4	a.	a.	NOUN
admet-923	1054	5	avdeef	avdeef	PROPN
admet-923	1054	6	,	,	PUNCT
admet-923	1054	7	k.y	k.y	PROPN
admet-923	1054	8	.	.	PROPN
admet-923	1054	9	tam	tam	PROPN
admet-923	1054	10	.	.	PUNCT
admet-923	1055	1	how	how	SCONJ
admet-923	1055	2	well	well	ADV
admet-923	1055	3	can	can	AUX
admet-923	1055	4	the	the	DET
admet-923	1055	5	caco-2	caco-2	NUM
admet-923	1055	6	/	/	SYM
admet-923	1055	7	madin	madin	VERB
admet-923	1055	8	-	-	PUNCT
admet-923	1055	9	darby	darby	PROPN
admet-923	1055	10	canine	canine	PROPN
admet-923	1055	11	kidney	kidney	NOUN
admet-923	1055	12	models	model	NOUN
admet-923	1055	13	predict	predict	VERB
admet-923	1055	14	effective	effective	ADJ
admet-923	1055	15	human	human	ADJ
admet-923	1055	16	jejunal	jejunal	ADJ
admet-923	1055	17	permeability	permeability	NOUN
admet-923	1055	18	?	?	PUNCT
admet-923	1056	1	j.	j.	PROPN
admet-923	1056	2	med	med	PROPN
admet-923	1056	3	.	.	PROPN
admet-923	1056	4	chem	chem	PROPN
admet-923	1056	5	.	.	PUNCT
admet-923	1057	1	53	53	NUM
admet-923	1057	2	(	(	PUNCT
admet-923	1057	3	2010	2010	NUM
admet-923	1057	4	)	)	PUNCT
admet-923	1057	5	3566–3584	3566–3584	NUM
admet-923	1057	6	.	.	PUNCT
admet-923	1058	1	[	[	X
admet-923	1058	2	75	75	NUM
admet-923	1058	3	]	]	X
admet-923	1058	4	a.e	a.e	PROPN
admet-923	1058	5	.	.	PROPN
admet-923	1058	6	riedmaier	riedmaier	NOUN
admet-923	1058	7	,	,	PUNCT
admet-923	1058	8	k.	k.	PROPN
admet-923	1058	9	dement	dement	PROPN
admet-923	1058	10	,	,	PUNCT
admet-923	1058	11	j.	j.	PROPN
admet-923	1058	12	huckle	huckle	PROPN
admet-923	1058	13	,	,	PUNCT
admet-923	1058	14	p.	p.	NOUN
admet-923	1058	15	bransford	bransford	PROPN
admet-923	1058	16	,	,	PUNCT
admet-923	1058	17	c.	c.	PROPN
admet-923	1058	18	stillhart	stillhart	PROPN
admet-923	1058	19	,	,	PUNCT
admet-923	1058	20	r.	r.	PROPN
admet-923	1058	21	lloyd	lloyd	PROPN
admet-923	1058	22	,	,	PUNCT
admet-923	1058	23	r.	r.	PROPN
admet-923	1058	24	alluri	alluri	PROPN
admet-923	1058	25	,	,	PUNCT
admet-923	1058	26	s.	s.	PROPN
admet-923	1058	27	basu	basu	PROPN
admet-923	1058	28	,	,	PUNCT
admet-923	1058	29	y.	y.	PROPN
admet-923	1058	30	chen	chen	PROPN
admet-923	1058	31	,	,	PUNCT
admet-923	1058	32	v.	v.	PROPN
admet-923	1058	33	dhamankar	dhamankar	PROPN
admet-923	1058	34	,	,	PUNCT
admet-923	1058	35	others	other	NOUN
admet-923	1058	36	.	.	PUNCT
admet-923	1059	1	use	use	NOUN
admet-923	1059	2	of	of	ADP
admet-923	1059	3	physiologically	physiologically	ADV
admet-923	1059	4	based	base	VERB
admet-923	1059	5	pharmacokinetic	pharmacokinetic	ADJ
admet-923	1059	6	(	(	PUNCT
admet-923	1059	7	pbpk	pbpk	NOUN
admet-923	1059	8	)	)	PUNCT
admet-923	1059	9	modeling	modeling	NOUN
admet-923	1059	10	for	for	ADP
admet-923	1059	11	predicting	predict	VERB
admet-923	1059	12	drug	drug	NOUN
admet-923	1059	13	-	-	PUNCT
admet-923	1059	14	food	food	NOUN
admet-923	1059	15	interactions	interaction	NOUN
admet-923	1059	16	:	:	PUNCT
admet-923	1059	17	an	an	DET
admet-923	1059	18	industry	industry	NOUN
admet-923	1059	19	perspective	perspective	NOUN
admet-923	1059	20	.	.	PUNCT
admet-923	1060	1	aaps	aap	NOUN
admet-923	1060	2	j.	j.	PROPN
admet-923	1060	3	22	22	NUM
admet-923	1060	4	(	(	PUNCT
admet-923	1060	5	2020	2020	NUM
admet-923	1060	6	)	)	PUNCT
admet-923	1060	7	1–15	1–15	NUM
admet-923	1060	8	.	.	PUNCT
admet-923	1061	1	[	[	X
admet-923	1061	2	76	76	NUM
admet-923	1061	3	]	]	X
admet-923	1061	4	s.	s.	PROPN
admet-923	1061	5	j.e	j.e	PROPN
admet-923	1061	6	.	.	PROPN
admet-923	1061	7	,	,	PUNCT
admet-923	1061	8	y.	y.	PROPN
admet-923	1061	9	j.	j.	PROPN
admet-923	1061	10	,	,	PUNCT
admet-923	1061	11	r.-m	r.-m	PROPN
admet-923	1061	12	.	.	PUNCT
admet-923	1062	1	i.	i.	PROPN
admet-923	1062	2	,	,	PUNCT
admet-923	1062	3	i.	i.	PROPN
admet-923	1062	4	n.	n.	PROPN
admet-923	1062	5	physiologically	physiologically	ADV
admet-923	1062	6	based	base	VERB
admet-923	1062	7	pharmacokinetic	pharmacokinetic	ADJ
admet-923	1062	8	(	(	PUNCT
admet-923	1062	9	pbpk	pbpk	NOUN
admet-923	1062	10	)	)	PUNCT
admet-923	1062	11	modeling	modeling	NOUN
admet-923	1062	12	and	and	CCONJ
admet-923	1062	13	simulation	simulation	NOUN
admet-923	1062	14	approaches	approach	NOUN
admet-923	1062	15	:	:	PUNCT
admet-923	1062	16	a	a	DET
admet-923	1062	17	systematic	systematic	ADJ
admet-923	1062	18	review	review	NOUN
admet-923	1062	19	of	of	ADP
admet-923	1062	20	published	publish	VERB
admet-923	1062	21	models	model	NOUN
admet-923	1062	22	,	,	PUNCT
admet-923	1062	23	applications	application	NOUN
admet-923	1062	24	,	,	PUNCT
admet-923	1062	25	and	and	CCONJ
admet-923	1062	26	model	model	NOUN
admet-923	1062	27	verification	verification	NOUN
admet-923	1062	28	.	.	PUNCT
admet-923	1063	1	drug	drug	NOUN
admet-923	1063	2	metab	metab	NOUN
admet-923	1063	3	.	.	PUNCT
admet-923	1064	1	dispos	dispos	PROPN
admet-923	1064	2	.	.	PUNCT
admet-923	1065	1	43	43	NUM
admet-923	1065	2	(	(	PUNCT
admet-923	1065	3	2015	2015	NUM
admet-923	1065	4	)	)	PUNCT
admet-923	1065	5	1823–1837	1823–1837	NUM
admet-923	1065	6	.	.	PUNCT
admet-923	1066	1	[	[	X
admet-923	1066	2	77	77	NUM
admet-923	1066	3	]	]	X
admet-923	1066	4	v.p	v.p	PROPN
admet-923	1066	5	.	.	PROPN
admet-923	1066	6	shah	shah	PROPN
admet-923	1066	7	,	,	PUNCT
admet-923	1066	8	g.l	g.l	PROPN
admet-923	1066	9	.	.	PROPN
admet-923	1066	10	amidon	amidon	PROPN
admet-923	1066	11	.	.	PUNCT
admet-923	1067	1	g.l	g.l	PROPN
admet-923	1067	2	.	.	PROPN
admet-923	1067	3	amidon	amidon	PROPN
admet-923	1067	4	,	,	PUNCT
admet-923	1067	5	h.	h.	PROPN
admet-923	1067	6	lennernas	lennernas	PROPN
admet-923	1067	7	,	,	PUNCT
admet-923	1067	8	v.p	v.p	PROPN
admet-923	1067	9	.	.	PROPN
admet-923	1067	10	shah	shah	PROPN
admet-923	1067	11	,	,	PUNCT
admet-923	1067	12	and	and	CCONJ
admet-923	1067	13	j.r	j.r	PROPN
admet-923	1067	14	.	.	PROPN
admet-923	1067	15	crison	crison	PROPN
admet-923	1067	16	.	.	PUNCT
admet-923	1068	1	a	a	DET
admet-923	1068	2	theoretical	theoretical	ADJ
admet-923	1068	3	basis	basis	NOUN
admet-923	1068	4	for	for	ADP
admet-923	1068	5	a	a	DET
admet-923	1068	6	biopharmaceutic	biopharmaceutic	ADJ
admet-923	1068	7	drug	drug	NOUN
admet-923	1068	8	classification	classification	NOUN
admet-923	1068	9	:	:	PUNCT
admet-923	1068	10	the	the	DET
admet-923	1068	11	correlation	correlation	NOUN
admet-923	1068	12	of	of	ADP
admet-923	1068	13	in	in	ADP
admet-923	1068	14	vitro	vitro	X
admet-923	1068	15	drug	drug	NOUN
admet-923	1068	16	product	product	NOUN
admet-923	1068	17	dissolution	dissolution	NOUN
admet-923	1068	18	and	and	CCONJ
admet-923	1068	19	in	in	ADP
admet-923	1068	20	vivo	vivo	ADJ
admet-923	1068	21	bioavailability	bioavailability	NOUN
admet-923	1068	22	,	,	PUNCT
admet-923	1068	23	pharm	pharm	NOUN
admet-923	1068	24	res	re	NOUN
admet-923	1068	25	12	12	NUM
admet-923	1068	26	,	,	PUNCT
admet-923	1068	27	413–420	413–420	NUM
admet-923	1068	28	,	,	PUNCT
admet-923	1068	29	1995	1995	NUM
admet-923	1068	30	—	—	PUNCT
admet-923	1068	31	backstory	backstory	NOUN
admet-923	1068	32	of	of	ADP
admet-923	1068	33	bcs	bc	NOUN
admet-923	1068	34	.	.	PUNCT
admet-923	1069	1	aaps	aap	NOUN
admet-923	1069	2	j.	j.	PROPN
admet-923	1069	3	16	16	NUM
admet-923	1069	4	(	(	PUNCT
admet-923	1069	5	2014	2014	NUM
admet-923	1069	6	)	)	PUNCT
admet-923	1069	7	894–898	894–898	NUM
admet-923	1069	8	.	.	PUNCT
admet-923	1070	1	[	[	X
admet-923	1070	2	78	78	NUM
admet-923	1070	3	]	]	PUNCT
admet-923	1070	4	a.	a.	NOUN
admet-923	1070	5	margolskee	margolskee	PROPN
admet-923	1070	6	,	,	PUNCT
admet-923	1070	7	a.s	a.s	PROPN
admet-923	1070	8	.	.	PROPN
admet-923	1070	9	darwich	darwich	PROPN
admet-923	1070	10	,	,	PUNCT
admet-923	1070	11	x.	x.	PROPN
admet-923	1070	12	pepin	pepin	PROPN
admet-923	1070	13	,	,	PUNCT
admet-923	1070	14	l.	l.	PROPN
admet-923	1070	15	aarons	aarons	PROPN
admet-923	1070	16	,	,	PUNCT
admet-923	1070	17	a.	a.	NOUN
admet-923	1070	18	galetin	galetin	PROPN
admet-923	1070	19	,	,	PUNCT
admet-923	1070	20	a.	a.	NOUN
admet-923	1070	21	rostami	rostami	PROPN
admet-923	1070	22	-	-	PUNCT
admet-923	1070	23	hodjegan	hodjegan	PROPN
admet-923	1070	24	,	,	PUNCT
admet-923	1070	25	s.	s.	PROPN
admet-923	1070	26	carlert	carlert	PROPN
admet-923	1070	27	,	,	PUNCT
admet-923	1070	28	m.	m.	PROPN
admet-923	1070	29	hammarberg	hammarberg	PROPN
admet-923	1070	30	,	,	PUNCT
admet-923	1070	31	c.	c.	PROPN
admet-923	1070	32	hilgendorf	hilgendorf	PROPN
admet-923	1070	33	,	,	PUNCT
admet-923	1070	34	p.	p.	PROPN
admet-923	1070	35	johansson	johansson	PROPN
admet-923	1070	36	,	,	PUNCT
admet-923	1070	37	e.	e.	PROPN
admet-923	1070	38	karlsson	karlsson	PROPN
admet-923	1070	39	,	,	PUNCT
admet-923	1070	40	d.	d.	PROPN
admet-923	1070	41	murphy	murphy	PROPN
admet-923	1070	42	,	,	PUNCT
admet-923	1070	43	c.	c.	PROPN
admet-923	1070	44	tannergren	tannergren	PROPN
admet-923	1070	45	,	,	PUNCT
admet-923	1070	46	h.	h.	PROPN
admet-923	1070	47	thörn	thörn	PROPN
admet-923	1070	48	,	,	PUNCT
admet-923	1070	49	m.	m.	NOUN
admet-923	1070	50	yasin	yasin	PROPN
admet-923	1070	51	,	,	PUNCT
admet-923	1070	52	f.	f.	PROPN
admet-923	1070	53	mazuir	mazuir	PROPN
admet-923	1070	54	,	,	PUNCT
admet-923	1070	55	o.	o.	PROPN
admet-923	1070	56	nicolas	nicolas	PROPN
admet-923	1070	57	,	,	PUNCT
admet-923	1070	58	s.	s.	PROPN
admet-923	1070	59	ramusovic	ramusovic	PROPN
admet-923	1070	60	,	,	PUNCT
admet-923	1070	61	c.	c.	PROPN
admet-923	1070	62	xu	xu	PROPN
admet-923	1070	63	,	,	PUNCT
admet-923	1070	64	s.m	s.m	PROPN
admet-923	1070	65	.	.	PROPN
admet-923	1070	66	pathak	pathak	PROPN
admet-923	1070	67	,	,	PUNCT
admet-923	1070	68	t.	t.	PROPN
admet-923	1070	69	korjamo	korjamo	PROPN
admet-923	1070	70	,	,	PUNCT
admet-923	1070	71	j.	j.	PROPN
admet-923	1070	72	laru	laru	PROPN
admet-923	1070	73	,	,	PUNCT
admet-923	1070	74	j.	j.	PROPN
admet-923	1070	75	malkki	malkki	PROPN
admet-923	1070	76	,	,	PUNCT
admet-923	1070	77	s.	s.	PROPN
admet-923	1070	78	pappinen	pappinen	PROPN
admet-923	1070	79	,	,	PUNCT
admet-923	1070	80	j.	j.	PROPN
admet-923	1070	81	admet	admet	PROPN
admet-923	1070	82	&	&	CCONJ
admet-923	1070	83	dmpk	dmpk	PROPN
admet-923	1070	84	9(2	9(2	NUM
admet-923	1070	85	)	)	PUNCT
admet-923	1070	86	(	(	PUNCT
admet-923	1070	87	2021	2021	NUM
admet-923	1070	88	)	)	PUNCT
admet-923	1070	89	75	75	NUM
admet-923	1070	90	-	-	SYM
admet-923	1070	91	109	109	NUM
admet-923	1070	92	lost	lose	VERB
admet-923	1070	93	in	in	ADP
admet-923	1070	94	modelling	modelling	NOUN
admet-923	1070	95	and	and	CCONJ
admet-923	1070	96	simulation	simulation	NOUN
admet-923	1070	97	?	?	PUNCT
admet-923	1071	1	doi	doi	NOUN
admet-923	1071	2	:	:	PUNCT
admet-923	1071	3	https:/doi.org/10.5599	https:/doi.org/10.5599	PROPN
admet-923	1071	4	/	/	SYM
admet-923	1071	5	admet.923	admet.923	PROPN
admet-923	1071	6	103	103	NUM
admet-923	1071	7	tuunainen	tuunainen	NOUN
admet-923	1071	8	,	,	PUNCT
admet-923	1071	9	j.	j.	PROPN
admet-923	1071	10	dressman	dressman	PROPN
admet-923	1071	11	,	,	PUNCT
admet-923	1071	12	s.	s.	PROPN
admet-923	1071	13	hansmann	hansmann	PROPN
admet-923	1071	14	,	,	PUNCT
admet-923	1071	15	e.	e.	PROPN
admet-923	1071	16	kostewicz	kostewicz	PROPN
admet-923	1071	17	,	,	PUNCT
admet-923	1071	18	h.	h.	PROPN
admet-923	1071	19	he	he	PROPN
admet-923	1071	20	,	,	PUNCT
admet-923	1071	21	t.	t.	PROPN
admet-923	1071	22	heimbach	heimbach	PROPN
admet-923	1071	23	,	,	PUNCT
admet-923	1071	24	f.	f.	PROPN
admet-923	1071	25	wu	wu	PROPN
admet-923	1071	26	,	,	PUNCT
admet-923	1071	27	c.	c.	PROPN
admet-923	1071	28	hoft	hoft	PROPN
admet-923	1071	29	,	,	PUNCT
admet-923	1071	30	l.	l.	PROPN
admet-923	1071	31	laplanche	laplanche	PROPN
admet-923	1071	32	,	,	PUNCT
admet-923	1071	33	y.	y.	PROPN
admet-923	1071	34	pang	pang	PROPN
admet-923	1071	35	,	,	PUNCT
admet-923	1071	36	m.b	m.b	PROPN
admet-923	1071	37	.	.	PROPN
admet-923	1071	38	bolger	bolger	PROPN
admet-923	1071	39	,	,	PUNCT
admet-923	1071	40	e.	e.	PROPN
admet-923	1071	41	huehn	huehn	PROPN
admet-923	1071	42	,	,	PUNCT
admet-923	1071	43	v.	v.	PROPN
admet-923	1071	44	lukacova	lukacova	PROPN
admet-923	1071	45	,	,	PUNCT
admet-923	1071	46	j.m	j.m	PROPN
admet-923	1071	47	.	.	PROPN
admet-923	1071	48	mullin	mullin	PROPN
admet-923	1071	49	,	,	PUNCT
admet-923	1071	50	k.x	k.x	PROPN
admet-923	1071	51	.	.	PROPN
admet-923	1071	52	szeto	szeto	PROPN
admet-923	1071	53	,	,	PUNCT
admet-923	1071	54	c.	c.	PROPN
admet-923	1071	55	costales	costales	PROPN
admet-923	1071	56	,	,	PUNCT
admet-923	1071	57	j.	j.	PROPN
admet-923	1071	58	lin	lin	PROPN
admet-923	1071	59	,	,	PUNCT
admet-923	1071	60	m.	m.	NOUN
admet-923	1071	61	mcallister	mcallister	PROPN
admet-923	1071	62	,	,	PUNCT
admet-923	1071	63	s.	s.	PROPN
admet-923	1071	64	modi	modi	PROPN
admet-923	1071	65	,	,	PUNCT
admet-923	1071	66	c.	c.	PROPN
admet-923	1071	67	rotter	rotter	PROPN
admet-923	1071	68	,	,	PUNCT
admet-923	1071	69	m.	m.	NOUN
admet-923	1071	70	varma	varma	PROPN
admet-923	1071	71	,	,	PUNCT
admet-923	1071	72	m.	m.	PROPN
admet-923	1071	73	wong	wong	PROPN
admet-923	1071	74	,	,	PUNCT
admet-923	1071	75	a.	a.	PROPN
admet-923	1071	76	mitra	mitra	PROPN
admet-923	1071	77	,	,	PUNCT
admet-923	1071	78	j.	j.	PROPN
admet-923	1071	79	bevernage	bevernage	PROPN
admet-923	1071	80	,	,	PUNCT
admet-923	1071	81	j.	j.	PROPN
admet-923	1071	82	biewenga	biewenga	PROPN
admet-923	1071	83	,	,	PUNCT
admet-923	1071	84	a.	a.	PROPN
admet-923	1071	85	van	van	PROPN
admet-923	1071	86	peer	peer	PROPN
admet-923	1071	87	,	,	PUNCT
admet-923	1071	88	r.	r.	PROPN
admet-923	1071	89	lloyd	lloyd	PROPN
admet-923	1071	90	,	,	PUNCT
admet-923	1071	91	c.	c.	PROPN
admet-923	1071	92	shardlow	shardlow	PROPN
admet-923	1071	93	,	,	PUNCT
admet-923	1071	94	p.	p.	PROPN
admet-923	1071	95	langguth	langguth	PROPN
admet-923	1071	96	,	,	PUNCT
admet-923	1071	97	i.	i.	PROPN
admet-923	1071	98	mishenzon	mishenzon	PROPN
admet-923	1071	99	,	,	PUNCT
admet-923	1071	100	m.a	m.a	PROPN
admet-923	1071	101	.	.	PROPN
admet-923	1071	102	nguyen	nguyen	PROPN
admet-923	1071	103	,	,	PUNCT
admet-923	1071	104	j.	j.	PROPN
admet-923	1071	105	brown	brown	PROPN
admet-923	1071	106	,	,	PUNCT
admet-923	1071	107	h.	h.	PROPN
admet-923	1071	108	lennernäs	lennernäs	PROPN
admet-923	1071	109	,	,	PUNCT
admet-923	1071	110	b.	b.	PROPN
admet-923	1071	111	abrahamsson	abrahamsson	PROPN
admet-923	1071	112	.	.	PUNCT
admet-923	1072	1	imi	imi	PROPN
admet-923	1072	2	–	–	PUNCT
admet-923	1072	3	oral	oral	ADJ
admet-923	1072	4	biopharmaceutics	biopharmaceutics	NOUN
admet-923	1072	5	tools	tool	NOUN
admet-923	1072	6	project	project	NOUN
admet-923	1072	7	–	–	PUNCT
admet-923	1072	8	evaluation	evaluation	NOUN
admet-923	1072	9	of	of	ADP
admet-923	1072	10	bottom	bottom	ADJ
admet-923	1072	11	-	-	PUNCT
admet-923	1072	12	up	up	ADP
admet-923	1072	13	pbpk	pbpk	NOUN
admet-923	1072	14	prediction	prediction	NOUN
admet-923	1072	15	success	success	NOUN
admet-923	1072	16	part	part	NOUN
admet-923	1072	17	2	2	NUM
admet-923	1072	18	:	:	PUNCT
admet-923	1072	19	an	an	DET
admet-923	1072	20	introduction	introduction	NOUN
admet-923	1072	21	to	to	ADP
admet-923	1072	22	the	the	DET
admet-923	1072	23	simulation	simulation	NOUN
admet-923	1072	24	exercise	exercise	NOUN
admet-923	1072	25	and	and	CCONJ
admet-923	1072	26	overview	overview	NOUN
admet-923	1072	27	of	of	ADP
admet-923	1072	28	results	result	NOUN
admet-923	1072	29	.	.	PUNCT
admet-923	1073	1	eur	eur	PROPN
admet-923	1073	2	.	.	PUNCT
admet-923	1074	1	j.	j.	PROPN
admet-923	1074	2	pharm	pharm	PROPN
admet-923	1074	3	.	.	PUNCT
admet-923	1075	1	sci	sci	PROPN
admet-923	1075	2	.	.	PROPN
admet-923	1076	1	96	96	NUM
admet-923	1076	2	(	(	PUNCT
admet-923	1076	3	2017	2017	NUM
admet-923	1076	4	)	)	PUNCT
admet-923	1077	1	610–625	610–625	NUM
admet-923	1077	2	.	.	PUNCT
admet-923	1078	1	[	[	X
admet-923	1078	2	79	79	NUM
admet-923	1078	3	]	]	X
admet-923	1078	4	n.	n.	NOUN
admet-923	1078	5	matsumura	matsumura	ADV
admet-923	1078	6	,	,	PUNCT
admet-923	1078	7	a.	a.	PROPN
admet-923	1078	8	ono	ono	PROPN
admet-923	1078	9	,	,	PUNCT
admet-923	1078	10	y.	y.	PROPN
admet-923	1078	11	akiyama	akiyama	PROPN
admet-923	1078	12	,	,	PUNCT
admet-923	1078	13	t.	t.	PROPN
admet-923	1078	14	fujita	fujita	PROPN
admet-923	1078	15	,	,	PUNCT
admet-923	1078	16	k.	k.	PROPN
admet-923	1078	17	sugano	sugano	PROPN
admet-923	1078	18	.	.	PUNCT
admet-923	1079	1	bottom	bottom	ADJ
admet-923	1079	2	-	-	PUNCT
admet-923	1079	3	up	up	ADP
admet-923	1079	4	physiologically	physiologically	ADV
admet-923	1079	5	based	base	VERB
admet-923	1079	6	oral	oral	ADJ
admet-923	1079	7	absorption	absorption	NOUN
admet-923	1079	8	modeling	modeling	NOUN
admet-923	1079	9	of	of	ADP
admet-923	1079	10	free	free	ADJ
admet-923	1079	11	weak	weak	ADJ
admet-923	1079	12	base	base	NOUN
admet-923	1079	13	drugs	drug	NOUN
admet-923	1079	14	.	.	PUNCT
admet-923	1080	1	pharmaceutics	pharmaceutic	NOUN
admet-923	1080	2	.	.	PUNCT
admet-923	1081	1	12	12	NUM
admet-923	1081	2	(	(	PUNCT
admet-923	1081	3	2020	2020	NUM
admet-923	1081	4	)	)	PUNCT
admet-923	1081	5	844	844	NUM
admet-923	1081	6	.	.	PUNCT
admet-923	1082	1	[	[	X
admet-923	1082	2	80	80	NUM
admet-923	1082	3	]	]	X
admet-923	1082	4	m.v.s	m.v.s	NOUN
admet-923	1082	5	.	.	PUNCT
admet-923	1082	6	varma	varma	PROPN
admet-923	1082	7	,	,	PUNCT
admet-923	1082	8	r.s	r.s	PROPN
admet-923	1082	9	.	.	PROPN
admet-923	1082	10	obach	obach	PROPN
admet-923	1082	11	,	,	PUNCT
admet-923	1082	12	c.	c.	PROPN
admet-923	1082	13	rotter	rotter	PROPN
admet-923	1082	14	,	,	PUNCT
admet-923	1082	15	h.r	h.r	PROPN
admet-923	1082	16	.	.	PROPN
admet-923	1082	17	miller	miller	PROPN
admet-923	1082	18	,	,	PUNCT
admet-923	1082	19	g.	g.	PROPN
admet-923	1082	20	chang	chang	PROPN
admet-923	1082	21	,	,	PUNCT
admet-923	1082	22	s.j	s.j	PROPN
admet-923	1082	23	.	.	PROPN
admet-923	1082	24	steyn	steyn	PROPN
admet-923	1082	25	,	,	PUNCT
admet-923	1082	26	a.	a.	PROPN
admet-923	1082	27	el	el	PROPN
admet-923	1082	28	-	-	PROPN
admet-923	1082	29	kattan	kattan	PROPN
admet-923	1082	30	,	,	PUNCT
admet-923	1082	31	m.d	m.d	PROPN
admet-923	1082	32	.	.	PROPN
admet-923	1082	33	troutman	troutman	PROPN
admet-923	1082	34	.	.	PUNCT
admet-923	1083	1	physicochemical	physicochemical	ADJ
admet-923	1083	2	space	space	NOUN
admet-923	1083	3	for	for	ADP
admet-923	1083	4	optimum	optimum	ADJ
admet-923	1083	5	oral	oral	ADJ
admet-923	1083	6	bioavailability	bioavailability	NOUN
admet-923	1083	7	:	:	PUNCT
admet-923	1083	8	contribution	contribution	NOUN
admet-923	1083	9	of	of	ADP
admet-923	1083	10	human	human	ADJ
admet-923	1083	11	intestinal	intestinal	ADJ
admet-923	1083	12	absorption	absorption	NOUN
admet-923	1083	13	and	and	CCONJ
admet-923	1083	14	first	first	ADJ
admet-923	1083	15	-	-	PUNCT
admet-923	1083	16	pass	pass	NOUN
admet-923	1083	17	elimination	elimination	NOUN
admet-923	1083	18	.	.	PUNCT
admet-923	1084	1	j.	j.	PROPN
admet-923	1084	2	med	med	PROPN
admet-923	1084	3	.	.	PROPN
admet-923	1084	4	chem	chem	PROPN
admet-923	1084	5	.	.	PUNCT
admet-923	1085	1	53	53	NUM
admet-923	1085	2	(	(	PUNCT
admet-923	1085	3	2010	2010	NUM
admet-923	1085	4	)	)	PUNCT
admet-923	1085	5	1098–1108	1098–1108	NUM
admet-923	1085	6	.	.	PUNCT
admet-923	1086	1	[	[	X
admet-923	1086	2	81	81	NUM
admet-923	1086	3	]	]	PUNCT
admet-923	1086	4	r.	r.	PROPN
admet-923	1086	5	takano	takano	PROPN
admet-923	1086	6	,	,	PUNCT
admet-923	1086	7	k.	k.	PROPN
admet-923	1086	8	sugano	sugano	PROPN
admet-923	1086	9	,	,	PUNCT
admet-923	1086	10	a.	a.	PROPN
admet-923	1086	11	higashida	higashida	PROPN
admet-923	1086	12	,	,	PUNCT
admet-923	1086	13	y.	y.	PROPN
admet-923	1086	14	hayashi	hayashi	PROPN
admet-923	1086	15	,	,	PUNCT
admet-923	1086	16	m.	m.	PROPN
admet-923	1086	17	machida	machida	PROPN
admet-923	1086	18	,	,	PUNCT
admet-923	1086	19	y.	y.	PROPN
admet-923	1086	20	aso	aso	PROPN
admet-923	1086	21	,	,	PUNCT
admet-923	1086	22	s.	s.	PROPN
admet-923	1086	23	yamashita	yamashita	PROPN
admet-923	1086	24	.	.	PUNCT
admet-923	1087	1	oral	oral	ADJ
admet-923	1087	2	absorption	absorption	NOUN
admet-923	1087	3	of	of	ADP
admet-923	1087	4	poorly	poorly	ADV
admet-923	1087	5	water	water	NOUN
admet-923	1087	6	-	-	PUNCT
admet-923	1087	7	soluble	soluble	ADJ
admet-923	1087	8	drugs	drug	NOUN
admet-923	1087	9	:	:	PUNCT
admet-923	1087	10	computer	computer	NOUN
admet-923	1087	11	simulation	simulation	NOUN
admet-923	1087	12	of	of	ADP
admet-923	1087	13	fraction	fraction	NOUN
admet-923	1087	14	absorbed	absorb	VERB
admet-923	1087	15	in	in	ADP
admet-923	1087	16	humans	human	NOUN
admet-923	1087	17	from	from	ADP
admet-923	1087	18	a	a	DET
admet-923	1087	19	miniscale	miniscale	ADJ
admet-923	1087	20	dissolution	dissolution	NOUN
admet-923	1087	21	test	test	NOUN
admet-923	1087	22	.	.	PUNCT
admet-923	1088	1	pharm	pharm	NOUN
admet-923	1088	2	.	.	PUNCT
admet-923	1089	1	res	re	NOUN
admet-923	1089	2	.	.	PUNCT
admet-923	1090	1	23	23	NUM
admet-923	1090	2	(	(	PUNCT
admet-923	1090	3	2006	2006	NUM
admet-923	1090	4	)	)	PUNCT
admet-923	1090	5	1144–1156	1144–1156	NUM
admet-923	1090	6	.	.	PUNCT
admet-923	1091	1	[	[	X
admet-923	1091	2	82	82	NUM
admet-923	1091	3	]	]	X
admet-923	1091	4	r.	r.	PROPN
admet-923	1091	5	takano	takano	PROPN
admet-923	1091	6	,	,	PUNCT
admet-923	1091	7	k.	k.	PROPN
admet-923	1091	8	sugano	sugano	PROPN
admet-923	1091	9	,	,	PUNCT
admet-923	1091	10	a.	a.	PROPN
admet-923	1091	11	higashida	higashida	PROPN
admet-923	1091	12	,	,	PUNCT
admet-923	1091	13	y.	y.	PROPN
admet-923	1091	14	hayashi	hayashi	PROPN
admet-923	1091	15	,	,	PUNCT
admet-923	1091	16	m.	m.	PROPN
admet-923	1091	17	machida	machida	PROPN
admet-923	1091	18	,	,	PUNCT
admet-923	1091	19	y.	y.	PROPN
admet-923	1091	20	aso	aso	PROPN
admet-923	1091	21	,	,	PUNCT
admet-923	1091	22	s.	s.	PROPN
admet-923	1091	23	yamashita	yamashita	PROPN
admet-923	1091	24	.	.	PUNCT
admet-923	1092	1	oral	oral	ADJ
admet-923	1092	2	absorption	absorption	NOUN
admet-923	1092	3	of	of	ADP
admet-923	1092	4	poorly	poorly	ADV
admet-923	1092	5	water	water	NOUN
admet-923	1092	6	-	-	PUNCT
admet-923	1092	7	soluble	soluble	ADJ
admet-923	1092	8	drugs	drug	NOUN
admet-923	1092	9	:	:	PUNCT
admet-923	1092	10	computer	computer	NOUN
admet-923	1092	11	simulation	simulation	NOUN
admet-923	1092	12	of	of	ADP
admet-923	1092	13	fraction	fraction	NOUN
admet-923	1092	14	absorbed	absorb	VERB
admet-923	1092	15	in	in	ADP
admet-923	1092	16	humans	human	NOUN
admet-923	1092	17	from	from	ADP
admet-923	1092	18	a	a	DET
admet-923	1092	19	miniscale	miniscale	ADJ
admet-923	1092	20	dissolution	dissolution	NOUN
admet-923	1092	21	test	test	NOUN
admet-923	1092	22	.	.	PUNCT
admet-923	1093	1	pharm	pharm	NOUN
admet-923	1093	2	.	.	PUNCT
admet-923	1094	1	res	re	NOUN
admet-923	1094	2	.	.	PUNCT
admet-923	1095	1	23	23	NUM
admet-923	1095	2	(	(	PUNCT
admet-923	1095	3	2006	2006	NUM
admet-923	1095	4	)	)	PUNCT
admet-923	1095	5	.	.	PUNCT
admet-923	1096	1	[	[	X
admet-923	1096	2	83	83	NUM
admet-923	1096	3	]	]	PUNCT
admet-923	1096	4	k.	k.	PROPN
admet-923	1096	5	sugano	sugano	PROPN
admet-923	1096	6	.	.	PUNCT
admet-923	1097	1	fraction	fraction	NOUN
admet-923	1097	2	of	of	ADP
admet-923	1097	3	a	a	DET
admet-923	1097	4	dose	dose	NOUN
admet-923	1097	5	absorbed	absorb	VERB
admet-923	1097	6	estimation	estimation	NOUN
admet-923	1097	7	for	for	ADP
admet-923	1097	8	structurally	structurally	ADV
admet-923	1097	9	diverse	diverse	ADJ
admet-923	1097	10	low	low	ADJ
admet-923	1097	11	solubility	solubility	NOUN
admet-923	1097	12	compounds	compound	NOUN
admet-923	1097	13	.	.	PUNCT
admet-923	1098	1	int	int	NOUN
admet-923	1098	2	.	.	PUNCT
admet-923	1099	1	j.	j.	PROPN
admet-923	1099	2	pharm	pharm	PROPN
admet-923	1099	3	.	.	PUNCT
admet-923	1100	1	405	405	NUM
admet-923	1100	2	(	(	PUNCT
admet-923	1100	3	2011	2011	NUM
admet-923	1100	4	)	)	PUNCT
admet-923	1100	5	.	.	PUNCT
admet-923	1101	1	[	[	X
admet-923	1101	2	84	84	NUM
admet-923	1101	3	]	]	X
admet-923	1101	4	n.	n.	PROPN
admet-923	1101	5	hisada	hisada	PROPN
admet-923	1101	6	,	,	PUNCT
admet-923	1101	7	r.	r.	PROPN
admet-923	1101	8	takano	takano	PROPN
admet-923	1101	9	,	,	PUNCT
admet-923	1101	10	n.	n.	NOUN
admet-923	1101	11	takata	takata	PROPN
admet-923	1101	12	,	,	PUNCT
admet-923	1101	13	k.	k.	PROPN
admet-923	1101	14	shiraki	shiraki	PROPN
admet-923	1101	15	,	,	PUNCT
admet-923	1101	16	t.	t.	PROPN
admet-923	1101	17	ueto	ueto	PROPN
admet-923	1101	18	,	,	PUNCT
admet-923	1101	19	s.	s.	PROPN
admet-923	1101	20	tanida	tanida	PROPN
admet-923	1101	21	,	,	PUNCT
admet-923	1101	22	m.	m.	NOUN
admet-923	1101	23	kataoka	kataoka	PROPN
admet-923	1101	24	,	,	PUNCT
admet-923	1101	25	s.	s.	PROPN
admet-923	1101	26	yamashita	yamashita	PROPN
admet-923	1101	27	.	.	PUNCT
admet-923	1102	1	characterizing	characterize	VERB
admet-923	1102	2	the	the	DET
admet-923	1102	3	dissolution	dissolution	ADJ
admet-923	1102	4	profiles	profile	NOUN
admet-923	1102	5	of	of	ADP
admet-923	1102	6	supersaturable	supersaturable	ADJ
admet-923	1102	7	salts	salt	NOUN
admet-923	1102	8	,	,	PUNCT
admet-923	1102	9	cocrystals	cocrystal	NOUN
admet-923	1102	10	,	,	PUNCT
admet-923	1102	11	and	and	CCONJ
admet-923	1102	12	solvates	solvate	VERB
admet-923	1102	13	to	to	PART
admet-923	1102	14	enhance	enhance	VERB
admet-923	1102	15	in	in	ADP
admet-923	1102	16	vivo	vivo	ADJ
admet-923	1102	17	oral	oral	ADJ
admet-923	1102	18	absorption	absorption	NOUN
admet-923	1102	19	.	.	PUNCT
admet-923	1103	1	eur	eur	PROPN
admet-923	1103	2	.	.	PUNCT
admet-923	1104	1	j.	j.	PROPN
admet-923	1104	2	pharm	pharm	PROPN
admet-923	1104	3	.	.	PUNCT
admet-923	1105	1	biopharm	biopharm	PROPN
admet-923	1105	2	.	.	PUNCT
admet-923	1106	1	103	103	NUM
admet-923	1106	2	(	(	PUNCT
admet-923	1106	3	2016	2016	NUM
admet-923	1106	4	)	)	PUNCT
admet-923	1106	5	192–199	192–199	NUM
admet-923	1106	6	.	.	PUNCT
admet-923	1107	1	[	[	X
admet-923	1107	2	85	85	NUM
admet-923	1107	3	]	]	PUNCT
admet-923	1107	4	k.	k.	PROPN
admet-923	1107	5	sugano	sugano	PROPN
admet-923	1107	6	,	,	PUNCT
admet-923	1107	7	m.	m.	PROPN
admet-923	1107	8	kansy	kansy	PROPN
admet-923	1107	9	,	,	PUNCT
admet-923	1107	10	p.	p.	PROPN
admet-923	1107	11	artursson	artursson	PROPN
admet-923	1107	12	,	,	PUNCT
admet-923	1107	13	a.	a.	PROPN
admet-923	1107	14	avdeef	avdeef	PROPN
admet-923	1107	15	,	,	PUNCT
admet-923	1107	16	s.	s.	PROPN
admet-923	1107	17	bendels	bendels	PROPN
admet-923	1107	18	,	,	PUNCT
admet-923	1107	19	l.	l.	PROPN
admet-923	1107	20	di	di	PROPN
admet-923	1107	21	,	,	PUNCT
admet-923	1107	22	g.f	g.f	PROPN
admet-923	1107	23	.	.	PROPN
admet-923	1107	24	ecker	ecker	PROPN
admet-923	1107	25	,	,	PUNCT
admet-923	1107	26	b.	b.	PROPN
admet-923	1107	27	faller	faller	PROPN
admet-923	1107	28	,	,	PUNCT
admet-923	1107	29	h.	h.	PROPN
admet-923	1107	30	fischer	fischer	PROPN
admet-923	1107	31	,	,	PUNCT
admet-923	1107	32	g.	g.	PROPN
admet-923	1107	33	gerebtzoff	gerebtzoff	PROPN
admet-923	1107	34	,	,	PUNCT
admet-923	1107	35	h.	h.	PROPN
admet-923	1107	36	lennernaes	lennernaes	PROPN
admet-923	1107	37	,	,	PUNCT
admet-923	1107	38	f.	f.	PROPN
admet-923	1107	39	senner	senner	PROPN
admet-923	1107	40	.	.	PUNCT
admet-923	1108	1	coexistence	coexistence	NOUN
admet-923	1108	2	of	of	ADP
admet-923	1108	3	passive	passive	ADJ
admet-923	1108	4	and	and	CCONJ
admet-923	1108	5	carrier	carrier	NOUN
admet-923	1108	6	-	-	PUNCT
admet-923	1108	7	mediated	mediate	VERB
admet-923	1108	8	processes	process	NOUN
admet-923	1108	9	in	in	ADP
admet-923	1108	10	drug	drug	NOUN
admet-923	1108	11	transport	transport	NOUN
admet-923	1108	12	.	.	PUNCT
admet-923	1109	1	nat	nat	PROPN
admet-923	1109	2	.	.	PUNCT
admet-923	1110	1	rev	rev	PROPN
admet-923	1110	2	.	.	PROPN
admet-923	1110	3	drug	drug	NOUN
admet-923	1110	4	discov	discov	NOUN
admet-923	1110	5	.	.	PUNCT
admet-923	1111	1	9	9	NUM
admet-923	1111	2	(	(	PUNCT
admet-923	1111	3	2010	2010	NUM
admet-923	1111	4	)	)	PUNCT
admet-923	1111	5	.	.	PUNCT
admet-923	1112	1	[	[	X
admet-923	1112	2	86	86	NUM
admet-923	1112	3	]	]	PUNCT
admet-923	1112	4	k.	k.	PROPN
admet-923	1112	5	sugano	sugano	PROPN
admet-923	1112	6	.	.	PUNCT
admet-923	1113	1	biopharmaceutics	biopharmaceutics	NOUN
admet-923	1113	2	modeling	modeling	NOUN
admet-923	1113	3	and	and	CCONJ
admet-923	1113	4	simulations	simulation	NOUN
admet-923	1113	5	:	:	PUNCT
admet-923	1114	1	theory	theory	NOUN
admet-923	1114	2	,	,	PUNCT
admet-923	1114	3	practice	practice	NOUN
admet-923	1114	4	,	,	PUNCT
admet-923	1114	5	methods	method	NOUN
admet-923	1114	6	,	,	PUNCT
admet-923	1114	7	and	and	CCONJ
admet-923	1114	8	applications	application	NOUN
admet-923	1114	9	,	,	PUNCT
admet-923	1114	10	wiley	wiley	PROPN
admet-923	1114	11	,	,	PUNCT
admet-923	1114	12	n.d	n.d	PROPN
admet-923	1114	13	.	.	PUNCT
admet-923	1115	1	[	[	X
admet-923	1115	2	87	87	NUM
admet-923	1115	3	]	]	PUNCT
admet-923	1115	4	p.	p.	NOUN
admet-923	1115	5	wils	wils	PROPN
admet-923	1115	6	,	,	PUNCT
admet-923	1115	7	a.	a.	NOUN
admet-923	1115	8	warnery	warnery	PROPN
admet-923	1115	9	,	,	PUNCT
admet-923	1115	10	v.	v.	CCONJ
admet-923	1115	11	phung	phung	PROPN
admet-923	1115	12	-	-	PUNCT
admet-923	1115	13	ba	ba	PROPN
admet-923	1115	14	,	,	PUNCT
admet-923	1115	15	s.	s.	PROPN
admet-923	1115	16	legrain	legrain	PROPN
admet-923	1115	17	,	,	PUNCT
admet-923	1115	18	d.	d.	PROPN
admet-923	1115	19	scherman	scherman	PROPN
admet-923	1115	20	.	.	PUNCT
admet-923	1116	1	high	high	ADJ
admet-923	1116	2	lipophilicity	lipophilicity	NOUN
admet-923	1116	3	decreases	decrease	VERB
admet-923	1116	4	drug	drug	NOUN
admet-923	1116	5	transport	transport	NOUN
admet-923	1116	6	across	across	ADP
admet-923	1116	7	intestinal	intestinal	ADJ
admet-923	1116	8	epithelial	epithelial	ADJ
admet-923	1116	9	cells	cell	NOUN
admet-923	1116	10	.	.	PUNCT
admet-923	1117	1	j.	j.	PROPN
admet-923	1117	2	pharmacol	pharmacol	PROPN
admet-923	1117	3	.	.	PUNCT
admet-923	1118	1	exp	exp	PROPN
admet-923	1118	2	.	.	PUNCT
admet-923	1119	1	ther	ther	PROPN
admet-923	1119	2	.	.	PUNCT
admet-923	1120	1	269	269	NUM
admet-923	1120	2	(	(	PUNCT
admet-923	1120	3	1994	1994	NUM
admet-923	1120	4	)	)	PUNCT
admet-923	1121	1	654–658	654–658	NUM
admet-923	1121	2	.	.	PUNCT
admet-923	1122	1	[	[	X
admet-923	1122	2	88	88	NUM
admet-923	1122	3	]	]	X
admet-923	1122	4	g.	g.	PROPN
admet-923	1122	5	krishna	krishna	PROPN
admet-923	1122	6	,	,	PUNCT
admet-923	1122	7	k.j	k.j	PROPN
admet-923	1122	8	.	.	PROPN
admet-923	1122	9	chen	chen	PROPN
admet-923	1122	10	,	,	PUNCT
admet-923	1122	11	c.c	c.c	PROPN
admet-923	1122	12	.	.	PROPN
admet-923	1122	13	lin	lin	PROPN
admet-923	1122	14	,	,	PUNCT
admet-923	1122	15	a.a	a.a	PROPN
admet-923	1122	16	.	.	PROPN
admet-923	1122	17	nomeir	nomeir	PROPN
admet-923	1122	18	.	.	PUNCT
admet-923	1123	1	permeability	permeability	NOUN
admet-923	1123	2	of	of	ADP
admet-923	1123	3	lipophilic	lipophilic	ADJ
admet-923	1123	4	compounds	compound	NOUN
admet-923	1123	5	in	in	ADP
admet-923	1123	6	drug	drug	NOUN
admet-923	1123	7	discovery	discovery	NOUN
admet-923	1123	8	using	use	VERB
admet-923	1123	9	in	in	ADP
admet-923	1123	10	-	-	PUNCT
admet-923	1123	11	vitro	vitro	X
admet-923	1123	12	human	human	ADJ
admet-923	1123	13	absorption	absorption	NOUN
admet-923	1123	14	model	model	NOUN
admet-923	1123	15	,	,	PUNCT
admet-923	1123	16	caco-2	caco-2	PROPN
admet-923	1123	17	.	.	PUNCT
admet-923	1123	18	int	int	NOUN
admet-923	1123	19	.	.	PUNCT
admet-923	1124	1	j.	j.	PROPN
admet-923	1124	2	pharm	pharm	PROPN
admet-923	1124	3	.	.	PUNCT
admet-923	1125	1	222	222	NUM
admet-923	1125	2	(	(	PUNCT
admet-923	1125	3	2001	2001	NUM
admet-923	1125	4	)	)	PUNCT
admet-923	1125	5	77–89	77–89	NUM
admet-923	1125	6	.	.	PUNCT
admet-923	1126	1	[	[	X
admet-923	1126	2	89	89	NUM
admet-923	1126	3	]	]	X
admet-923	1126	4	r.	r.	PROPN
admet-923	1126	5	saitoh	saitoh	PROPN
admet-923	1126	6	,	,	PUNCT
admet-923	1126	7	k.	k.	PROPN
admet-923	1126	8	sugano	sugano	PROPN
admet-923	1126	9	,	,	PUNCT
admet-923	1126	10	n.	n.	NOUN
admet-923	1126	11	takata	takata	NOUN
admet-923	1126	12	,	,	PUNCT
admet-923	1126	13	t.	t.	PROPN
admet-923	1126	14	tachibana	tachibana	PROPN
admet-923	1126	15	,	,	PUNCT
admet-923	1126	16	a.	a.	PROPN
admet-923	1126	17	higashida	higashida	PROPN
admet-923	1126	18	,	,	PUNCT
admet-923	1126	19	y.	y.	PROPN
admet-923	1126	20	nabuchi	nabuchi	PROPN
admet-923	1126	21	,	,	PUNCT
admet-923	1126	22	y.	y.	PROPN
admet-923	1126	23	aso	aso	PROPN
admet-923	1126	24	.	.	PUNCT
admet-923	1127	1	correction	correction	NOUN
admet-923	1127	2	of	of	ADP
admet-923	1127	3	permeability	permeability	NOUN
admet-923	1127	4	with	with	ADP
admet-923	1127	5	pore	pore	ADJ
admet-923	1127	6	radius	radius	NOUN
admet-923	1127	7	of	of	ADP
admet-923	1127	8	tight	tight	ADJ
admet-923	1127	9	junctions	junction	NOUN
admet-923	1127	10	in	in	ADP
admet-923	1127	11	caco-2	caco-2	NUM
admet-923	1127	12	monolayers	monolayer	NOUN
admet-923	1127	13	improves	improve	VERB
admet-923	1127	14	the	the	DET
admet-923	1127	15	prediction	prediction	NOUN
admet-923	1127	16	of	of	ADP
admet-923	1127	17	the	the	DET
admet-923	1127	18	dose	dose	NOUN
admet-923	1127	19	fraction	fraction	NOUN
admet-923	1127	20	of	of	ADP
admet-923	1127	21	hydrophilic	hydrophilic	ADJ
admet-923	1127	22	drugs	drug	NOUN
admet-923	1127	23	absorbed	absorb	VERB
admet-923	1127	24	by	by	ADP
admet-923	1127	25	humans	human	NOUN
admet-923	1127	26	.	.	PUNCT
admet-923	1128	1	pharm	pharm	NOUN
admet-923	1128	2	.	.	PUNCT
admet-923	1129	1	res	re	NOUN
admet-923	1129	2	.	.	PROPN
admet-923	1130	1	21	21	NUM
admet-923	1130	2	(	(	PUNCT
admet-923	1130	3	2004	2004	NUM
admet-923	1130	4	)	)	PUNCT
admet-923	1130	5	.	.	PUNCT
admet-923	1131	1	[	[	X
admet-923	1131	2	90	90	NUM
admet-923	1131	3	]	]	PUNCT
admet-923	1131	4	k.	k.	PROPN
admet-923	1131	5	sugano	sugano	PROPN
admet-923	1131	6	,	,	PUNCT
admet-923	1131	7	n.	n.	NOUN
admet-923	1131	8	takata	takata	NOUN
admet-923	1131	9	,	,	PUNCT
admet-923	1131	10	m.	m.	PROPN
admet-923	1131	11	machida	machida	PROPN
admet-923	1131	12	,	,	PUNCT
admet-923	1131	13	k.	k.	PROPN
admet-923	1131	14	saitoh	saitoh	PROPN
admet-923	1131	15	,	,	PUNCT
admet-923	1131	16	k.	k.	PROPN
admet-923	1131	17	terada	terada	PROPN
admet-923	1131	18	.	.	PUNCT
admet-923	1132	1	prediction	prediction	NOUN
admet-923	1132	2	of	of	ADP
admet-923	1132	3	passive	passive	ADJ
admet-923	1132	4	intestinal	intestinal	ADJ
admet-923	1132	5	absorption	absorption	NOUN
admet-923	1132	6	using	use	VERB
admet-923	1132	7	bio	bio	ADJ
admet-923	1132	8	-	-	ADJ
admet-923	1132	9	mimetic	mimetic	ADJ
admet-923	1132	10	artificial	artificial	ADJ
admet-923	1132	11	membrane	membrane	NOUN
admet-923	1132	12	permeation	permeation	NOUN
admet-923	1132	13	assay	assay	NOUN
admet-923	1132	14	and	and	CCONJ
admet-923	1132	15	the	the	DET
admet-923	1132	16	paracellular	paracellular	ADJ
admet-923	1132	17	pathway	pathway	NOUN
admet-923	1132	18	model	model	NOUN
admet-923	1132	19	.	.	PUNCT
admet-923	1133	1	int	int	NOUN
admet-923	1133	2	.	.	PUNCT
admet-923	1134	1	j.	j.	PROPN
admet-923	1134	2	pharm	pharm	PROPN
admet-923	1134	3	.	.	PUNCT
admet-923	1135	1	241	241	NUM
admet-923	1135	2	(	(	PUNCT
admet-923	1135	3	2002	2002	NUM
admet-923	1135	4	)	)	PUNCT
admet-923	1135	5	.	.	PUNCT
admet-923	1136	1	[	[	X
admet-923	1136	2	91	91	NUM
admet-923	1136	3	]	]	X
admet-923	1136	4	g.e	g.e	PROPN
admet-923	1136	5	.	.	PROPN
admet-923	1136	6	amidon	amidon	PROPN
admet-923	1136	7	,	,	PUNCT
admet-923	1136	8	w.i	w.i	PROPN
admet-923	1136	9	.	.	PROPN
admet-923	1136	10	higuchi	higuchi	PROPN
admet-923	1136	11	,	,	PUNCT
admet-923	1136	12	n.f.h	n.f.h	PROPN
admet-923	1136	13	.	.	PUNCT
admet-923	1136	14	ho	ho	PROPN
admet-923	1136	15	.	.	PROPN
admet-923	1136	16	theoretical	theoretical	ADJ
admet-923	1136	17	and	and	CCONJ
admet-923	1136	18	experimental	experimental	ADJ
admet-923	1136	19	studies	study	NOUN
admet-923	1136	20	of	of	ADP
admet-923	1136	21	transport	transport	NOUN
admet-923	1136	22	of	of	ADP
admet-923	1136	23	micellesolubilized	micellesolubilize	VERB
admet-923	1136	24	solutes	solute	NOUN
admet-923	1136	25	.	.	PUNCT
admet-923	1137	1	j.	j.	PROPN
admet-923	1137	2	pharm	pharm	PROPN
admet-923	1137	3	.	.	PUNCT
admet-923	1138	1	sci	sci	PROPN
admet-923	1138	2	.	.	PROPN
admet-923	1139	1	71	71	NUM
admet-923	1139	2	(	(	PUNCT
admet-923	1139	3	1982	1982	NUM
admet-923	1139	4	)	)	PUNCT
admet-923	1139	5	77–84	77–84	NOUN
admet-923	1139	6	.	.	PUNCT
admet-923	1140	1	[	[	X
admet-923	1140	2	92	92	NUM
admet-923	1140	3	]	]	PUNCT
admet-923	1140	4	t.	t.	PROPN
admet-923	1140	5	yamaguchi	yamaguchi	PROPN
admet-923	1140	6	,	,	PUNCT
admet-923	1140	7	c.	c.	PROPN
admet-923	1140	8	ikeda	ikeda	PROPN
admet-923	1140	9	,	,	PUNCT
admet-923	1140	10	y.	y.	PROPN
admet-923	1140	11	sekine	sekine	PROPN
admet-923	1140	12	.	.	PUNCT
admet-923	1141	1	intestinal	intestinal	ADJ
admet-923	1141	2	absorption	absorption	NOUN
admet-923	1141	3	of	of	ADP
admet-923	1141	4	$	$	SYM
admet-923	1141	5	β$-adrenergic	β$-adrenergic	ADJ
admet-923	1141	6	blocking	block	VERB
admet-923	1141	7	agent	agent	NOUN
admet-923	1141	8	nadolol	nadolol	NOUN
admet-923	1141	9	.	.	PUNCT
admet-923	1142	1	i.	i.	NOUN
admet-923	1142	2	:	:	PUNCT
admet-923	1142	3	comparison	comparison	NOUN
admet-923	1142	4	of	of	ADP
admet-923	1142	5	absorption	absorption	NOUN
admet-923	1142	6	behaivor	behaivor	NOUN
admet-923	1142	7	of	of	ADP
admet-923	1142	8	nadolol	nadolol	NOUN
admet-923	1142	9	with	with	ADP
admet-923	1142	10	those	those	PRON
admet-923	1142	11	of	of	ADP
admet-923	1142	12	other	other	ADJ
admet-923	1142	13	$	$	SYM
admet-923	1142	14	β$-blocking	β$-blocke	VERB
admet-923	1142	15	agents	agent	NOUN
admet-923	1142	16	in	in	ADP
admet-923	1142	17	rats	rat	NOUN
admet-923	1142	18	.	.	PUNCT
admet-923	1143	1	chem	chem	NOUN
admet-923	1143	2	.	.	PUNCT
admet-923	1144	1	pharm	pharm	NOUN
admet-923	1144	2	.	.	PUNCT
admet-923	1145	1	bull	bull	NOUN
admet-923	1145	2	.	.	PUNCT
admet-923	1146	1	34	34	NUM
admet-923	1146	2	(	(	PUNCT
admet-923	1146	3	1986	1986	NUM
admet-923	1146	4	)	)	PUNCT
admet-923	1146	5	3362–3369	3362–3369	NUM
admet-923	1146	6	.	.	PUNCT
admet-923	1147	1	[	[	X
admet-923	1147	2	93	93	NUM
admet-923	1147	3	]	]	PUNCT
admet-923	1147	4	f.g.j	f.g.j	NOUN
admet-923	1147	5	.	.	PUNCT
admet-923	1147	6	poelma	poelma	PROPN
admet-923	1147	7	,	,	PUNCT
admet-923	1147	8	r.	r.	PROPN
admet-923	1147	9	breäs	breäs	PROPN
admet-923	1147	10	,	,	PUNCT
admet-923	1147	11	j.j	j.j	PROPN
admet-923	1147	12	.	.	PROPN
admet-923	1147	13	tukker	tukker	PROPN
admet-923	1147	14	,	,	PUNCT
admet-923	1147	15	d.j.a	d.j.a	PROPN
admet-923	1147	16	.	.	PUNCT
admet-923	1147	17	crommelin	crommelin	PROPN
admet-923	1147	18	.	.	PUNCT
admet-923	1148	1	intestinal	intestinal	ADJ
admet-923	1148	2	absorption	absorption	NOUN
admet-923	1148	3	of	of	ADP
admet-923	1148	4	drugs	drug	NOUN
admet-923	1148	5	.	.	PUNCT
admet-923	1149	1	the	the	DET
admet-923	1149	2	influence	influence	NOUN
admet-923	1149	3	of	of	ADP
admet-923	1149	4	mixed	mixed	ADJ
admet-923	1149	5	micelles	micelle	NOUN
admet-923	1149	6	on	on	ADP
admet-923	1149	7	on	on	ADP
admet-923	1149	8	the	the	DET
admet-923	1149	9	disappearance	disappearance	NOUN
admet-923	1149	10	kinetics	kinetic	NOUN
admet-923	1149	11	of	of	ADP
admet-923	1149	12	drugs	drug	NOUN
admet-923	1149	13	from	from	ADP
admet-923	1149	14	the	the	DET
admet-923	1149	15	small	small	ADJ
admet-923	1149	16	intestine	intestine	NOUN
admet-923	1149	17	of	of	ADP
admet-923	1149	18	the	the	DET
admet-923	1149	19	rat	rat	NOUN
admet-923	1149	20	.	.	PUNCT
admet-923	1149	21	j.	j.	PROPN
admet-923	1149	22	pharm	pharm	PROPN
admet-923	1149	23	.	.	PUNCT
admet-923	1150	1	pharmacol	pharmacol	PROPN
admet-923	1150	2	.	.	PUNCT
admet-923	1151	1	43	43	NUM
admet-923	1151	2	(	(	PUNCT
admet-923	1151	3	1991	1991	NUM
admet-923	1151	4	)	)	PUNCT
admet-923	1152	1	317–324	317–324	NUM
admet-923	1152	2	.	.	PUNCT
admet-923	1153	1	[	[	X
admet-923	1153	2	94	94	NUM
admet-923	1153	3	]	]	X
admet-923	1153	4	f.	f.	PROPN
admet-923	1153	5	ingels	ingels	PROPN
admet-923	1153	6	,	,	PUNCT
admet-923	1153	7	b.	b.	PROPN
admet-923	1153	8	beck	beck	PROPN
admet-923	1153	9	,	,	PUNCT
admet-923	1153	10	m.	m.	PROPN
admet-923	1153	11	oth	oth	PROPN
admet-923	1153	12	,	,	PUNCT
admet-923	1153	13	p.	p.	NOUN
admet-923	1153	14	augustijns	augustijns	NOUN
admet-923	1153	15	.	.	PUNCT
admet-923	1154	1	effect	effect	NOUN
admet-923	1154	2	of	of	ADP
admet-923	1154	3	simulated	simulated	ADJ
admet-923	1154	4	intestinal	intestinal	ADJ
admet-923	1154	5	fluid	fluid	NOUN
admet-923	1154	6	on	on	ADP
admet-923	1154	7	drug	drug	NOUN
admet-923	1154	8	permeability	permeability	NOUN
admet-923	1154	9	estimation	estimation	NOUN
admet-923	1154	10	across	across	ADP
admet-923	1154	11	caco-2	caco-2	NUM
admet-923	1154	12	monolayers	monolayer	NOUN
admet-923	1154	13	.	.	PUNCT
admet-923	1155	1	int	int	NOUN
admet-923	1155	2	.	.	PUNCT
admet-923	1156	1	j.	j.	PROPN
admet-923	1156	2	pharm	pharm	PROPN
admet-923	1156	3	.	.	PUNCT
admet-923	1157	1	274	274	NUM
admet-923	1157	2	(	(	PUNCT
admet-923	1157	3	2004	2004	NUM
admet-923	1157	4	)	)	PUNCT
admet-923	1158	1	221–232	221–232	NUM
admet-923	1158	2	.	.	PUNCT
admet-923	1159	1	[	[	X
admet-923	1159	2	95	95	NUM
admet-923	1159	3	]	]	X
admet-923	1159	4	a.t	a.t	PROPN
admet-923	1159	5	.	.	PROPN
admet-923	1159	6	heikkinen	heikkinen	PROPN
admet-923	1159	7	,	,	PUNCT
admet-923	1159	8	j.	j.	PROPN
admet-923	1159	9	mönkkönen	mönkkönen	PROPN
admet-923	1159	10	,	,	PUNCT
admet-923	1159	11	t.	t.	PROPN
admet-923	1159	12	korjamo	korjamo	PROPN
admet-923	1159	13	.	.	PUNCT
admet-923	1160	1	determination	determination	NOUN
admet-923	1160	2	of	of	ADP
admet-923	1160	3	permeation	permeation	NOUN
admet-923	1160	4	resistance	resistance	NOUN
admet-923	1160	5	distribution	distribution	NOUN
admet-923	1160	6	in	in	ADP
admet-923	1160	7	in	in	ADP
admet-923	1160	8	vitro	vitro	X
admet-923	1160	9	cell	cell	NOUN
admet-923	1160	10	monolayer	monolayer	NOUN
admet-923	1160	11	permeation	permeation	NOUN
admet-923	1160	12	experiments	experiment	NOUN
admet-923	1160	13	.	.	PUNCT
admet-923	1161	1	eur	eur	PROPN
admet-923	1161	2	.	.	PUNCT
admet-923	1162	1	j.	j.	PROPN
admet-923	1162	2	pharm	pharm	PROPN
admet-923	1162	3	.	.	PUNCT
admet-923	1163	1	sci	sci	PROPN
admet-923	1163	2	.	.	PROPN
admet-923	1164	1	40	40	NUM
admet-923	1164	2	(	(	PUNCT
admet-923	1164	3	2010	2010	NUM
admet-923	1164	4	)	)	PUNCT
admet-923	1165	1	132–142	132–142	NUM
admet-923	1165	2	.	.	PUNCT
admet-923	1166	1	https://doi.org/10.5599/admet.923	https://doi.org/10.5599/admet.923	X
admet-923	1166	2	kiyohiko	kiyohiko	PROPN
admet-923	1166	3	sugano	sugano	PROPN
admet-923	1166	4	admet	admet	PROPN
admet-923	1166	5	&	&	CCONJ
admet-923	1166	6	dmpk	dmpk	PROPN
admet-923	1166	7	9(2	9(2	NUM
admet-923	1166	8	)	)	PUNCT
admet-923	1166	9	(	(	PUNCT
admet-923	1166	10	2021	2021	NUM
admet-923	1166	11	)	)	PUNCT
admet-923	1166	12	75	75	NUM
admet-923	1166	13	-	-	SYM
admet-923	1166	14	109	109	NUM
admet-923	1166	15	104	104	NUM
admet-923	1167	1	[	[	X
admet-923	1167	2	96	96	NUM
admet-923	1167	3	]	]	X
admet-923	1167	4	f.a	f.a	PROPN
admet-923	1167	5	.	.	PROPN
admet-923	1167	6	wilson	wilson	PROPN
admet-923	1167	7	,	,	PUNCT
admet-923	1167	8	v.l	v.l	PROPN
admet-923	1167	9	.	.	PROPN
admet-923	1167	10	sallee	sallee	PROPN
admet-923	1167	11	,	,	PUNCT
admet-923	1167	12	j.m	j.m	PROPN
admet-923	1167	13	.	.	PROPN
admet-923	1167	14	dietschy	dietschy	PROPN
admet-923	1167	15	.	.	PUNCT
admet-923	1168	1	unstirred	unstirred	ADJ
admet-923	1168	2	water	water	NOUN
admet-923	1168	3	layers	layer	NOUN
admet-923	1168	4	in	in	ADP
admet-923	1168	5	intestine	intestine	NOUN
admet-923	1168	6	:	:	PUNCT
admet-923	1168	7	rate	rate	NOUN
admet-923	1168	8	determinant	determinant	ADJ
admet-923	1168	9	of	of	ADP
admet-923	1168	10	fatty	fatty	NOUN
admet-923	1168	11	acid	acid	NOUN
admet-923	1168	12	absorption	absorption	NOUN
admet-923	1168	13	from	from	ADP
admet-923	1168	14	micellar	micellar	ADJ
admet-923	1168	15	solutions	solution	NOUN
admet-923	1168	16	.	.	PUNCT
admet-923	1169	1	science	science	NOUN
admet-923	1169	2	(	(	PUNCT
admet-923	1169	3	80-	80-	NUM
admet-923	1169	4	.	.	NUM
admet-923	1169	5	)	)	PUNCT
admet-923	1169	6	.	.	PUNCT
admet-923	1170	1	174	174	NUM
admet-923	1170	2	(	(	PUNCT
admet-923	1170	3	1971	1971	NUM
admet-923	1170	4	)	)	PUNCT
admet-923	1170	5	1031–1033	1031–1033	NUM
admet-923	1170	6	.	.	PUNCT
admet-923	1171	1	[	[	X
admet-923	1171	2	97	97	NUM
admet-923	1171	3	]	]	X
admet-923	1171	4	u.	u.	PROPN
admet-923	1171	5	fagerholm	fagerholm	PROPN
admet-923	1171	6	,	,	PUNCT
admet-923	1171	7	h.	h.	PROPN
admet-923	1171	8	lennernäs	lennernäs	PROPN
admet-923	1171	9	.	.	PUNCT
admet-923	1172	1	experimental	experimental	ADJ
admet-923	1172	2	estimation	estimation	NOUN
admet-923	1172	3	of	of	ADP
admet-923	1172	4	the	the	DET
admet-923	1172	5	effective	effective	ADJ
admet-923	1172	6	unstirred	unstirred	ADJ
admet-923	1172	7	water	water	NOUN
admet-923	1172	8	layer	layer	NOUN
admet-923	1172	9	thickness	thickness	NOUN
admet-923	1172	10	in	in	ADP
admet-923	1172	11	the	the	DET
admet-923	1172	12	human	human	ADJ
admet-923	1172	13	jejunum	jejunum	NOUN
admet-923	1172	14	,	,	PUNCT
admet-923	1172	15	and	and	CCONJ
admet-923	1172	16	its	its	PRON
admet-923	1172	17	importance	importance	NOUN
admet-923	1172	18	in	in	ADP
admet-923	1172	19	oral	oral	ADJ
admet-923	1172	20	drug	drug	NOUN
admet-923	1172	21	absorption	absorption	NOUN
admet-923	1172	22	.	.	PUNCT
admet-923	1173	1	eur	eur	PROPN
admet-923	1173	2	.	.	PUNCT
admet-923	1174	1	j.	j.	PROPN
admet-923	1174	2	pharm	pharm	PROPN
admet-923	1174	3	.	.	PUNCT
admet-923	1175	1	sci	sci	PROPN
admet-923	1175	2	.	.	PROPN
admet-923	1175	3	3	3	NUM
admet-923	1175	4	(	(	PUNCT
admet-923	1175	5	1995	1995	NUM
admet-923	1175	6	)	)	PUNCT
admet-923	1175	7	247	247	NUM
admet-923	1175	8	–	–	PUNCT
admet-923	1175	9	253	253	NUM
admet-923	1175	10	.	.	PUNCT
admet-923	1176	1	[	[	X
admet-923	1176	2	98	98	NUM
admet-923	1176	3	]	]	X
admet-923	1176	4	k.a	k.a	PROPN
admet-923	1176	5	.	.	PROPN
admet-923	1176	6	youdim	youdim	PROPN
admet-923	1176	7	,	,	PUNCT
admet-923	1176	8	a.	a.	PROPN
admet-923	1176	9	avdeef	avdeef	PROPN
admet-923	1176	10	,	,	PUNCT
admet-923	1176	11	n.j	n.j	PROPN
admet-923	1176	12	.	.	PROPN
admet-923	1176	13	abbott	abbott	PROPN
admet-923	1176	14	.	.	PUNCT
admet-923	1177	1	in	in	ADP
admet-923	1177	2	vitro	vitro	X
admet-923	1177	3	trans	trans	ADJ
admet-923	1177	4	-	-	ADJ
admet-923	1177	5	monolayer	monolayer	NOUN
admet-923	1177	6	permeability	permeability	NOUN
admet-923	1177	7	calculations	calculation	NOUN
admet-923	1177	8	:	:	PUNCT
admet-923	1177	9	often	often	ADV
admet-923	1177	10	forgotten	forget	VERB
admet-923	1177	11	assumptions	assumption	NOUN
admet-923	1177	12	.	.	PUNCT
admet-923	1178	1	drug	drug	NOUN
admet-923	1178	2	discov	discov	NOUN
admet-923	1178	3	.	.	PUNCT
admet-923	1179	1	today	today	NOUN
admet-923	1179	2	.	.	PUNCT
admet-923	1180	1	8	8	NUM
admet-923	1180	2	(	(	PUNCT
admet-923	1180	3	2003	2003	NUM
admet-923	1180	4	)	)	PUNCT
admet-923	1180	5	997–1003	997–1003	NUM
admet-923	1180	6	.	.	PUNCT
admet-923	1181	1	[	[	X
admet-923	1181	2	99	99	NUM
admet-923	1181	3	]	]	PUNCT
admet-923	1181	4	a.	a.	NOUN
admet-923	1181	5	olivares	olivare	NOUN
admet-923	1181	6	-	-	PUNCT
admet-923	1181	7	morales	morale	NOUN
admet-923	1181	8	,	,	PUNCT
admet-923	1181	9	h.	h.	PROPN
admet-923	1181	10	lennernäs	lennernäs	PROPN
admet-923	1181	11	,	,	PUNCT
admet-923	1181	12	l.	l.	PROPN
admet-923	1181	13	aarons	aarons	PROPN
admet-923	1181	14	,	,	PUNCT
admet-923	1181	15	a.	a.	NOUN
admet-923	1181	16	rostami	rostami	PROPN
admet-923	1181	17	-	-	PUNCT
admet-923	1181	18	hodjegan	hodjegan	PROPN
admet-923	1181	19	.	.	PUNCT
admet-923	1182	1	translating	translate	VERB
admet-923	1182	2	human	human	ADJ
admet-923	1182	3	effective	effective	ADJ
admet-923	1182	4	jejunal	jejunal	ADJ
admet-923	1182	5	intestinal	intestinal	ADJ
admet-923	1182	6	permeability	permeability	NOUN
admet-923	1182	7	to	to	ADP
admet-923	1182	8	surface	surface	NOUN
admet-923	1182	9	-	-	PUNCT
admet-923	1182	10	dependent	dependent	ADJ
admet-923	1182	11	intrinsic	intrinsic	ADJ
admet-923	1182	12	permeability	permeability	NOUN
admet-923	1182	13	:	:	PUNCT
admet-923	1182	14	a	a	DET
admet-923	1182	15	pragmatic	pragmatic	ADJ
admet-923	1182	16	method	method	NOUN
admet-923	1182	17	for	for	ADP
admet-923	1182	18	a	a	DET
admet-923	1182	19	more	more	ADV
admet-923	1182	20	mechanistic	mechanistic	ADJ
admet-923	1182	21	prediction	prediction	NOUN
admet-923	1182	22	of	of	ADP
admet-923	1182	23	regional	regional	ADJ
admet-923	1182	24	oral	oral	ADJ
admet-923	1182	25	drug	drug	NOUN
admet-923	1182	26	absorption	absorption	NOUN
admet-923	1182	27	.	.	PUNCT
admet-923	1183	1	aaps	aap	NOUN
admet-923	1183	2	j.	j.	PROPN
admet-923	1183	3	17	17	NUM
admet-923	1183	4	(	(	PUNCT
admet-923	1183	5	2015	2015	NUM
admet-923	1183	6	)	)	PUNCT
admet-923	1183	7	1177–1192	1177–1192	NUM
admet-923	1183	8	.	.	PUNCT
admet-923	1184	1	[	[	X
admet-923	1184	2	100	100	NUM
admet-923	1184	3	]	]	PUNCT
admet-923	1184	4	k.	k.	PROPN
admet-923	1184	5	sugano	sugano	PROPN
admet-923	1184	6	,	,	PUNCT
admet-923	1184	7	m.	m.	NOUN
admet-923	1184	8	kataoka	kataoka	PROPN
admet-923	1184	9	,	,	PUNCT
admet-923	1184	10	c.	c.	PROPN
admet-923	1184	11	da	da	PROPN
admet-923	1184	12	costa	costa	PROPN
admet-923	1184	13	mathews	mathews	PROPN
admet-923	1184	14	,	,	PUNCT
admet-923	1184	15	s.	s.	PROPN
admet-923	1184	16	yamashita	yamashita	PROPN
admet-923	1184	17	.	.	PUNCT
admet-923	1185	1	prediction	prediction	NOUN
admet-923	1185	2	of	of	ADP
admet-923	1185	3	food	food	NOUN
admet-923	1185	4	effect	effect	NOUN
admet-923	1185	5	by	by	ADP
admet-923	1185	6	bile	bile	NOUN
admet-923	1185	7	micelles	micelle	NOUN
admet-923	1185	8	on	on	ADP
admet-923	1185	9	oral	oral	ADJ
admet-923	1185	10	drug	drug	NOUN
admet-923	1185	11	absorption	absorption	NOUN
admet-923	1185	12	considering	consider	VERB
admet-923	1185	13	free	free	ADJ
admet-923	1185	14	fraction	fraction	NOUN
admet-923	1185	15	in	in	ADP
admet-923	1185	16	intestinal	intestinal	ADJ
admet-923	1185	17	fluid	fluid	NOUN
admet-923	1185	18	.	.	PUNCT
admet-923	1186	1	eur	eur	PROPN
admet-923	1186	2	.	.	PUNCT
admet-923	1187	1	j.	j.	PROPN
admet-923	1187	2	pharm	pharm	PROPN
admet-923	1187	3	.	.	PUNCT
admet-923	1188	1	sci	sci	PROPN
admet-923	1188	2	.	.	PROPN
admet-923	1189	1	40	40	NUM
admet-923	1189	2	(	(	PUNCT
admet-923	1189	3	2010	2010	NUM
admet-923	1189	4	)	)	PUNCT
admet-923	1189	5	118	118	NUM
admet-923	1189	6	–	–	PUNCT
admet-923	1189	7	124	124	NUM
admet-923	1189	8	.	.	PUNCT
admet-923	1190	1	[	[	X
admet-923	1190	2	101	101	NUM
admet-923	1190	3	]	]	PUNCT
admet-923	1190	4	t.	t.	PROPN
admet-923	1190	5	loftsson	loftsson	PROPN
admet-923	1190	6	,	,	PUNCT
admet-923	1190	7	f.	f.	PROPN
admet-923	1190	8	konrádsdóttir	konrádsdóttir	PROPN
admet-923	1190	9	,	,	PUNCT
admet-923	1190	10	m.	m.	NOUN
admet-923	1190	11	másson	másson	PROPN
admet-923	1190	12	.	.	PUNCT
admet-923	1191	1	influence	influence	NOUN
admet-923	1191	2	of	of	ADP
admet-923	1191	3	aqueous	aqueous	ADJ
admet-923	1191	4	diffusion	diffusion	NOUN
admet-923	1191	5	layer	layer	NOUN
admet-923	1191	6	on	on	ADP
admet-923	1191	7	passive	passive	ADJ
admet-923	1191	8	drug	drug	NOUN
admet-923	1191	9	diffusion	diffusion	NOUN
admet-923	1191	10	from	from	ADP
admet-923	1191	11	aqueous	aqueous	ADJ
admet-923	1191	12	cyclodextrin	cyclodextrin	NOUN
admet-923	1191	13	solutions	solution	NOUN
admet-923	1191	14	through	through	ADP
admet-923	1191	15	biological	biological	ADJ
admet-923	1191	16	membranes	membrane	NOUN
admet-923	1191	17	.	.	PUNCT
admet-923	1192	1	pharmazie	pharmazie	NOUN
admet-923	1192	2	.	.	PUNCT
admet-923	1193	1	61	61	NUM
admet-923	1193	2	(	(	PUNCT
admet-923	1193	3	2006	2006	NUM
admet-923	1193	4	)	)	PUNCT
admet-923	1193	5	83–89	83–89	NUM
admet-923	1193	6	.	.	PUNCT
admet-923	1194	1	[	[	X
admet-923	1194	2	102	102	NUM
admet-923	1194	3	]	]	X
admet-923	1194	4	a.	a.	NOUN
admet-923	1194	5	dahan	dahan	PROPN
admet-923	1194	6	,	,	PUNCT
admet-923	1194	7	j.m	j.m	PROPN
admet-923	1194	8	.	.	PROPN
admet-923	1194	9	miller	miller	PROPN
admet-923	1194	10	,	,	PUNCT
admet-923	1194	11	a.	a.	NOUN
admet-923	1194	12	hoffman	hoffman	PROPN
admet-923	1194	13	,	,	PUNCT
admet-923	1194	14	g.e	g.e	PROPN
admet-923	1194	15	.	.	PROPN
admet-923	1194	16	amidon	amidon	PROPN
admet-923	1194	17	,	,	PUNCT
admet-923	1194	18	g.l	g.l	PROPN
admet-923	1194	19	.	.	PROPN
admet-923	1194	20	amidon	amidon	PROPN
admet-923	1194	21	.	.	PUNCT
admet-923	1195	1	the	the	DET
admet-923	1195	2	solubility	solubility	NOUN
admet-923	1195	3	--	--	PUNCT
admet-923	1195	4	permeability	permeability	NOUN
admet-923	1195	5	interplay	interplay	NOUN
admet-923	1195	6	in	in	ADP
admet-923	1195	7	using	use	VERB
admet-923	1195	8	cyclodextrins	cyclodextrin	NOUN
admet-923	1195	9	as	as	ADP
admet-923	1195	10	pharmaceutical	pharmaceutical	ADJ
admet-923	1195	11	solubilizers	solubilizer	NOUN
admet-923	1195	12	:	:	PUNCT
admet-923	1195	13	mechanistic	mechanistic	ADJ
admet-923	1195	14	modeling	modeling	NOUN
admet-923	1195	15	and	and	CCONJ
admet-923	1195	16	application	application	NOUN
admet-923	1195	17	to	to	ADP
admet-923	1195	18	progesterone	progesterone	NOUN
admet-923	1195	19	.	.	PUNCT
admet-923	1196	1	j.	j.	PROPN
admet-923	1196	2	pharm	pharm	PROPN
admet-923	1196	3	.	.	PUNCT
admet-923	1197	1	sci	sci	PROPN
admet-923	1197	2	.	.	PROPN
admet-923	1198	1	99	99	NUM
admet-923	1198	2	(	(	PUNCT
admet-923	1198	3	2010	2010	NUM
admet-923	1198	4	)	)	PUNCT
admet-923	1198	5	2739–2749	2739–2749	NUM
admet-923	1198	6	.	.	PUNCT
admet-923	1199	1	[	[	X
admet-923	1199	2	103	103	NUM
admet-923	1199	3	]	]	X
admet-923	1199	4	r.e	r.e	PROPN
admet-923	1199	5	.	.	PROPN
admet-923	1199	6	oliver	oliver	PROPN
admet-923	1199	7	,	,	PUNCT
admet-923	1199	8	a.f	a.f	PROPN
admet-923	1199	9	.	.	PROPN
admet-923	1199	10	jones	jones	PROPN
admet-923	1199	11	,	,	PUNCT
admet-923	1199	12	m.	m.	NOUN
admet-923	1199	13	rowland	rowland	PROPN
admet-923	1199	14	.	.	PUNCT
admet-923	1200	1	what	what	PRON
admet-923	1200	2	surface	surface	NOUN
admet-923	1200	3	of	of	ADP
admet-923	1200	4	the	the	DET
admet-923	1200	5	intestinal	intestinal	ADJ
admet-923	1200	6	epithelium	epithelium	NOUN
admet-923	1200	7	is	be	AUX
admet-923	1200	8	effectively	effectively	ADV
admet-923	1200	9	available	available	ADJ
admet-923	1200	10	to	to	ADP
admet-923	1200	11	permeating	permeate	VERB
admet-923	1200	12	drugs	drug	NOUN
admet-923	1200	13	?	?	PUNCT
admet-923	1201	1	j.	j.	PROPN
admet-923	1201	2	pharm	pharm	PROPN
admet-923	1201	3	.	.	PUNCT
admet-923	1202	1	sci	sci	PROPN
admet-923	1202	2	.	.	PROPN
admet-923	1203	1	87	87	NUM
admet-923	1203	2	(	(	PUNCT
admet-923	1203	3	1998	1998	NUM
admet-923	1203	4	)	)	PUNCT
admet-923	1204	1	634–639	634–639	NUM
admet-923	1204	2	.	.	PUNCT
admet-923	1205	1	[	[	X
admet-923	1205	2	104	104	NUM
admet-923	1205	3	]	]	PUNCT
admet-923	1205	4	a.	a.	NOUN
admet-923	1205	5	avdeef	avdeef	PROPN
admet-923	1205	6	,	,	PUNCT
admet-923	1205	7	p.e	p.e	PROPN
admet-923	1205	8	.	.	PROPN
admet-923	1205	9	nielsen	nielsen	PROPN
admet-923	1205	10	,	,	PUNCT
admet-923	1205	11	o.	o.	PROPN
admet-923	1205	12	tsinman	tsinman	PROPN
admet-923	1205	13	.	.	PUNCT
admet-923	1206	1	pampa	pampa	VERB
admet-923	1206	2	a	a	DET
admet-923	1206	3	drug	drug	NOUN
admet-923	1206	4	absorption	absorption	NOUN
admet-923	1206	5	in	in	ADP
admet-923	1206	6	vitro	vitro	X
admet-923	1206	7	model	model	NOUN
admet-923	1206	8	:	:	PUNCT
admet-923	1206	9	11	11	NUM
admet-923	1206	10	.	.	PUNCT
admet-923	1207	1	matching	match	VERB
admet-923	1207	2	the	the	DET
admet-923	1207	3	in	in	ADP
admet-923	1207	4	vivo	vivo	ADJ
admet-923	1207	5	unstirred	unstirred	ADJ
admet-923	1207	6	water	water	NOUN
admet-923	1207	7	layer	layer	NOUN
admet-923	1207	8	thickness	thickness	NOUN
admet-923	1207	9	by	by	ADP
admet-923	1207	10	individual	individual	ADJ
admet-923	1207	11	-	-	PUNCT
admet-923	1207	12	well	well	ADV
admet-923	1207	13	stirring	stirring	NOUN
admet-923	1207	14	in	in	ADP
admet-923	1207	15	microtitre	microtitre	NOUN
admet-923	1207	16	plates	plate	NOUN
admet-923	1207	17	.	.	PUNCT
admet-923	1208	1	eur	eur	PROPN
admet-923	1208	2	.	.	PUNCT
admet-923	1209	1	j.	j.	PROPN
admet-923	1209	2	pharm	pharm	PROPN
admet-923	1209	3	.	.	PUNCT
admet-923	1210	1	sci	sci	PROPN
admet-923	1210	2	.	.	PROPN
admet-923	1211	1	22	22	NUM
admet-923	1211	2	(	(	PUNCT
admet-923	1211	3	2004	2004	NUM
admet-923	1211	4	)	)	PUNCT
admet-923	1212	1	365–374	365–374	NUM
admet-923	1212	2	.	.	PUNCT
admet-923	1213	1	[	[	X
admet-923	1213	2	105	105	NUM
admet-923	1213	3	]	]	X
admet-923	1213	4	m.	m.	NOUN
admet-923	1213	5	vertzoni	vertzoni	PROPN
admet-923	1213	6	,	,	PUNCT
admet-923	1213	7	e.	e.	PROPN
admet-923	1213	8	pastelli	pastelli	PROPN
admet-923	1213	9	,	,	PUNCT
admet-923	1213	10	d.	d.	PROPN
admet-923	1213	11	psachoulias	psachoulias	PROPN
admet-923	1213	12	,	,	PUNCT
admet-923	1213	13	l.	l.	PROPN
admet-923	1213	14	kalantzi	kalantzi	PROPN
admet-923	1213	15	,	,	PUNCT
admet-923	1213	16	c.	c.	PROPN
admet-923	1213	17	reppas	reppas	PROPN
admet-923	1213	18	.	.	PUNCT
admet-923	1214	1	estimation	estimation	NOUN
admet-923	1214	2	of	of	ADP
admet-923	1214	3	intragastric	intragastric	ADJ
admet-923	1214	4	solubility	solubility	NOUN
admet-923	1214	5	of	of	ADP
admet-923	1214	6	drugs	drug	NOUN
admet-923	1214	7	:	:	PUNCT
admet-923	1214	8	in	in	ADP
admet-923	1214	9	what	what	DET
admet-923	1214	10	medium	medium	ADJ
admet-923	1214	11	?	?	PUNCT
admet-923	1214	12	pharm	pharm	NOUN
admet-923	1214	13	.	.	PUNCT
admet-923	1215	1	res	re	NOUN
admet-923	1215	2	.	.	PROPN
admet-923	1216	1	24	24	NUM
admet-923	1216	2	(	(	PUNCT
admet-923	1216	3	2007	2007	NUM
admet-923	1216	4	)	)	PUNCT
admet-923	1217	1	909–917	909–917	NUM
admet-923	1217	2	.	.	PUNCT
admet-923	1218	1	[	[	X
admet-923	1218	2	106	106	NUM
admet-923	1218	3	]	]	X
admet-923	1218	4	a.t.m	a.t.m	X
admet-923	1218	5	.	.	PUNCT
admet-923	1219	1	serajuddin	serajuddin	PROPN
admet-923	1219	2	,	,	PUNCT
admet-923	1219	3	c.i	c.i	PROPN
admet-923	1219	4	.	.	PROPN
admet-923	1219	5	jarowski	jarowski	PROPN
admet-923	1219	6	.	.	PUNCT
admet-923	1220	1	effect	effect	NOUN
admet-923	1220	2	of	of	ADP
admet-923	1220	3	diffusion	diffusion	NOUN
admet-923	1220	4	layer	layer	NOUN
admet-923	1220	5	ph	ph	NOUN
admet-923	1220	6	and	and	CCONJ
admet-923	1220	7	solubility	solubility	NOUN
admet-923	1220	8	on	on	ADP
admet-923	1220	9	the	the	DET
admet-923	1220	10	dissolution	dissolution	NOUN
admet-923	1220	11	rate	rate	NOUN
admet-923	1220	12	of	of	ADP
admet-923	1220	13	pharmaceutical	pharmaceutical	NOUN
admet-923	1220	14	bases	basis	NOUN
admet-923	1220	15	and	and	CCONJ
admet-923	1220	16	their	their	PRON
admet-923	1220	17	hydrochloride	hydrochloride	NOUN
admet-923	1220	18	salts	salt	NOUN
admet-923	1220	19	i	i	PRON
admet-923	1220	20	:	:	PUNCT
admet-923	1220	21	phenazopyridine	phenazopyridine	PROPN
admet-923	1220	22	.	.	PUNCT
admet-923	1221	1	j.	j.	PROPN
admet-923	1221	2	pharm	pharm	PROPN
admet-923	1221	3	.	.	PUNCT
admet-923	1222	1	sci	sci	PROPN
admet-923	1222	2	.	.	PROPN
admet-923	1223	1	74	74	NUM
admet-923	1223	2	(	(	PUNCT
admet-923	1223	3	1985	1985	NUM
admet-923	1223	4	)	)	PUNCT
admet-923	1223	5	142	142	NUM
admet-923	1223	6	–	–	PUNCT
admet-923	1223	7	147	147	NUM
admet-923	1223	8	.	.	PUNCT
admet-923	1224	1	[	[	X
admet-923	1224	2	107	107	X
admet-923	1224	3	]	]	PUNCT
admet-923	1224	4	j.	j.	PROPN
admet-923	1224	5	al	al	PROPN
admet-923	1224	6	-	-	PUNCT
admet-923	1224	7	gousous	gousous	ADJ
admet-923	1224	8	,	,	PUNCT
admet-923	1224	9	n.	n.	PROPN
admet-923	1224	10	salehi	salehi	PROPN
admet-923	1224	11	,	,	PUNCT
admet-923	1224	12	g.e	g.e	PROPN
admet-923	1224	13	.	.	PROPN
admet-923	1224	14	amidon	amidon	PROPN
admet-923	1224	15	,	,	PUNCT
admet-923	1224	16	r.m	r.m	PROPN
admet-923	1224	17	.	.	PROPN
admet-923	1224	18	ziff	ziff	PROPN
admet-923	1224	19	,	,	PUNCT
admet-923	1224	20	p.	p.	PROPN
admet-923	1224	21	langguth	langguth	PROPN
admet-923	1224	22	,	,	PUNCT
admet-923	1224	23	g.l	g.l	PROPN
admet-923	1224	24	.	.	PROPN
admet-923	1224	25	amidon	amidon	PROPN
admet-923	1224	26	.	.	PUNCT
admet-923	1225	1	mass	mass	PROPN
admet-923	1225	2	transport	transport	NOUN
admet-923	1225	3	analysis	analysis	NOUN
admet-923	1225	4	of	of	ADP
admet-923	1225	5	bicarbonate	bicarbonate	NOUN
admet-923	1225	6	buffer	buffer	NOUN
admet-923	1225	7	:	:	PUNCT
admet-923	1225	8	effect	effect	NOUN
admet-923	1225	9	of	of	ADP
admet-923	1225	10	the	the	DET
admet-923	1225	11	co2	co2	NOUN
admet-923	1225	12	-	-	PUNCT
admet-923	1225	13	h2co3	h2co3	NOUN
admet-923	1225	14	hydration	hydration	NOUN
admet-923	1225	15	-	-	PUNCT
admet-923	1225	16	dehydration	dehydration	NOUN
admet-923	1225	17	kinetics	kinetic	NOUN
admet-923	1225	18	in	in	ADP
admet-923	1225	19	the	the	DET
admet-923	1225	20	fluid	fluid	ADJ
admet-923	1225	21	boundary	boundary	ADJ
admet-923	1225	22	layer	layer	NOUN
admet-923	1225	23	and	and	CCONJ
admet-923	1225	24	the	the	DET
admet-923	1225	25	apparent	apparent	ADJ
admet-923	1225	26	effective	effective	ADJ
admet-923	1225	27	p	p	PROPN
admet-923	1225	28	ka	ka	PROPN
admet-923	1225	29	controlling	control	VERB
admet-923	1225	30	dissolution	dissolution	NOUN
admet-923	1225	31	of	of	ADP
admet-923	1225	32	acids	acid	NOUN
admet-923	1225	33	and	and	CCONJ
admet-923	1225	34	bases	basis	NOUN
admet-923	1225	35	.	.	PUNCT
admet-923	1226	1	mol	mol	X
admet-923	1226	2	.	.	PUNCT
admet-923	1226	3	pharm	pharm	PROPN
admet-923	1226	4	.	.	PUNCT
admet-923	1227	1	16	16	NUM
admet-923	1227	2	(	(	PUNCT
admet-923	1227	3	2019	2019	NUM
admet-923	1227	4	)	)	PUNCT
admet-923	1227	5	2626–2635	2626–2635	NUM
admet-923	1227	6	.	.	PUNCT
admet-923	1228	1	[	[	X
admet-923	1228	2	108	108	NUM
admet-923	1228	3	]	]	PUNCT
admet-923	1228	4	k.	k.	PROPN
admet-923	1228	5	sugano	sugano	PROPN
admet-923	1228	6	,	,	PUNCT
admet-923	1228	7	a.	a.	PROPN
admet-923	1228	8	okazaki	okazaki	PROPN
admet-923	1228	9	,	,	PUNCT
admet-923	1228	10	s.	s.	PROPN
admet-923	1228	11	sugimoto	sugimoto	PROPN
admet-923	1228	12	,	,	PUNCT
admet-923	1228	13	s.	s.	PROPN
admet-923	1228	14	tavornvipas	tavornvipas	PROPN
admet-923	1228	15	,	,	PUNCT
admet-923	1228	16	a.	a.	NOUN
admet-923	1228	17	omura	omura	PROPN
admet-923	1228	18	,	,	PUNCT
admet-923	1228	19	t.	t.	PROPN
admet-923	1228	20	mano	mano	PROPN
admet-923	1228	21	.	.	PUNCT
admet-923	1229	1	solubility	solubility	NOUN
admet-923	1229	2	and	and	CCONJ
admet-923	1229	3	dissolution	dissolution	NOUN
admet-923	1229	4	profile	profile	NOUN
admet-923	1229	5	assessment	assessment	NOUN
admet-923	1229	6	in	in	ADP
admet-923	1229	7	drug	drug	NOUN
admet-923	1229	8	discovery	discovery	NOUN
admet-923	1229	9	.	.	PUNCT
admet-923	1230	1	drug	drug	NOUN
admet-923	1230	2	metab	metab	PROPN
admet-923	1230	3	.	.	PUNCT
admet-923	1231	1	pharmacokinet	pharmacokinet	NOUN
admet-923	1231	2	.	.	PUNCT
admet-923	1232	1	22	22	NUM
admet-923	1232	2	(	(	PUNCT
admet-923	1232	3	2007	2007	NUM
admet-923	1232	4	)	)	PUNCT
admet-923	1233	1	225–254	225–254	NUM
admet-923	1233	2	.	.	PUNCT
admet-923	1234	1	[	[	X
admet-923	1234	2	109	109	NUM
admet-923	1234	3	]	]	PUNCT
admet-923	1234	4	a.	a.	NOUN
admet-923	1234	5	ono	ono	PROPN
admet-923	1234	6	,	,	PUNCT
admet-923	1234	7	n.	n.	PROPN
admet-923	1234	8	matsumura	matsumura	ADV
admet-923	1234	9	,	,	PUNCT
admet-923	1234	10	t.	t.	PROPN
admet-923	1234	11	kimoto	kimoto	PROPN
admet-923	1234	12	,	,	PUNCT
admet-923	1234	13	y.	y.	PROPN
admet-923	1234	14	akiyama	akiyama	PROPN
admet-923	1234	15	,	,	PUNCT
admet-923	1234	16	s.	s.	PROPN
admet-923	1234	17	funaki	funaki	PROPN
admet-923	1234	18	,	,	PUNCT
admet-923	1234	19	n.	n.	PROPN
admet-923	1234	20	tamura	tamura	PROPN
admet-923	1234	21	,	,	PUNCT
admet-923	1234	22	s.	s.	PROPN
admet-923	1234	23	hayashi	hayashi	PROPN
admet-923	1234	24	,	,	PUNCT
admet-923	1234	25	y.	y.	PROPN
admet-923	1234	26	kojima	kojima	PROPN
admet-923	1234	27	,	,	PUNCT
admet-923	1234	28	m.	m.	NOUN
admet-923	1234	29	fushimi	fushimi	PROPN
admet-923	1234	30	,	,	PUNCT
admet-923	1234	31	h.	h.	PROPN
admet-923	1234	32	sudaki	sudaki	PROPN
admet-923	1234	33	,	,	PUNCT
admet-923	1234	34	others	other	NOUN
admet-923	1234	35	.	.	PUNCT
admet-923	1235	1	harmonizing	harmonize	VERB
admet-923	1235	2	solubility	solubility	NOUN
admet-923	1235	3	measurement	measurement	NOUN
admet-923	1235	4	to	to	PART
admet-923	1235	5	lower	lower	VERB
admet-923	1235	6	inter	inter	ADJ
admet-923	1235	7	-	-	ADJ
admet-923	1235	8	laboratory	laboratory	ADJ
admet-923	1235	9	variance	variance	NOUN
admet-923	1235	10	--	--	PUNCT
admet-923	1235	11	progress	progress	NOUN
admet-923	1235	12	of	of	ADP
admet-923	1235	13	consortium	consortium	NOUN
admet-923	1235	14	of	of	ADP
admet-923	1235	15	biopharmaceutical	biopharmaceutical	ADJ
admet-923	1235	16	tools	tool	NOUN
admet-923	1235	17	(	(	PUNCT
admet-923	1235	18	cobito	cobito	ADJ
admet-923	1235	19	)	)	PUNCT
admet-923	1235	20	in	in	ADP
admet-923	1235	21	japan	japan	PROPN
admet-923	1235	22	.	.	PUNCT
admet-923	1236	1	admet	admet	PROPN
admet-923	1236	2	dmpk	dmpk	PROPN
admet-923	1236	3	7	7	NUM
admet-923	1236	4	(	(	PUNCT
admet-923	1236	5	2019	2019	NUM
admet-923	1236	6	)	)	PUNCT
admet-923	1236	7	183–195	183–195	NUM
admet-923	1236	8	.	.	PUNCT
admet-923	1237	1	https://doi.org/10.5599/admet.704	https://doi.org/10.5599/admet.704	X
admet-923	1237	2	.	.	PUNCT
admet-923	1238	1	[	[	X
admet-923	1238	2	110	110	NUM
admet-923	1238	3	]	]	PUNCT
admet-923	1238	4	a.	a.	NOUN
admet-923	1238	5	avdeef	avdeef	PROPN
admet-923	1238	6	.	.	PUNCT
admet-923	1239	1	suggested	suggest	VERB
admet-923	1239	2	improvements	improvement	NOUN
admet-923	1239	3	for	for	ADP
admet-923	1239	4	measurement	measurement	NOUN
admet-923	1239	5	of	of	ADP
admet-923	1239	6	equilibrium	equilibrium	NOUN
admet-923	1239	7	solubility	solubility	NOUN
admet-923	1239	8	-	-	PUNCT
admet-923	1239	9	ph	ph	NOUN
admet-923	1239	10	of	of	ADP
admet-923	1239	11	ionizable	ionizable	ADJ
admet-923	1239	12	drugs	drug	NOUN
admet-923	1239	13	.	.	PUNCT
admet-923	1240	1	admet	admet	PROPN
admet-923	1240	2	dmpk	dmpk	PROPN
admet-923	1240	3	3	3	NUM
admet-923	1240	4	(	(	PUNCT
admet-923	1240	5	2015	2015	NUM
admet-923	1240	6	)	)	PUNCT
admet-923	1241	1	84–109	84–109	NUM
admet-923	1241	2	.	.	PUNCT
admet-923	1242	1	https://doi.org/10.5599/admet.3.2.193	https://doi.org/10.5599/admet.3.2.193	PROPN
admet-923	1242	2	.	.	PUNCT
admet-923	1243	1	[	[	X
admet-923	1243	2	111	111	NUM
admet-923	1243	3	]	]	PUNCT
admet-923	1243	4	a.	a.	NOUN
admet-923	1243	5	avdeef	avdeef	PROPN
admet-923	1243	6	,	,	PUNCT
admet-923	1243	7	e.	e.	PROPN
admet-923	1243	8	fuguet	fuguet	PROPN
admet-923	1243	9	,	,	PUNCT
admet-923	1243	10	a.	a.	PROPN
admet-923	1243	11	llinàs	llinàs	PROPN
admet-923	1243	12	,	,	PUNCT
admet-923	1243	13	c.	c.	PROPN
admet-923	1243	14	ràfols	ràfols	PROPN
admet-923	1243	15	,	,	PUNCT
admet-923	1243	16	e.	e.	PROPN
admet-923	1243	17	bosch	bosch	PROPN
admet-923	1243	18	,	,	PUNCT
admet-923	1243	19	g.	g.	PROPN
admet-923	1243	20	völgyi	völgyi	PROPN
admet-923	1243	21	,	,	PUNCT
admet-923	1243	22	t.	t.	NOUN
admet-923	1243	23	verbić	verbić	PROPN
admet-923	1243	24	,	,	PUNCT
admet-923	1243	25	e.	e.	PROPN
admet-923	1243	26	boldyreva	boldyreva	PROPN
admet-923	1243	27	,	,	PUNCT
admet-923	1243	28	k.	k.	PROPN
admet-923	1243	29	takács	takács	PROPN
admet-923	1243	30	-	-	PUNCT
admet-923	1243	31	novák	novák	PROPN
admet-923	1243	32	.	.	PUNCT
admet-923	1243	33	equilibrium	equilibrium	NOUN
admet-923	1243	34	solubility	solubility	NOUN
admet-923	1243	35	measurement	measurement	NOUN
admet-923	1243	36	of	of	ADP
admet-923	1243	37	ionizable	ionizable	ADJ
admet-923	1243	38	drugs	drug	NOUN
admet-923	1243	39	–	–	PUNCT
admet-923	1243	40	consensus	consensus	NOUN
admet-923	1243	41	recommendations	recommendation	NOUN
admet-923	1243	42	for	for	ADP
admet-923	1243	43	improving	improve	VERB
admet-923	1243	44	data	datum	NOUN
admet-923	1243	45	quality	quality	NOUN
admet-923	1243	46	.	.	PUNCT
admet-923	1244	1	admet	admet	PROPN
admet-923	1244	2	dmpk	dmpk	PROPN
admet-923	1244	3	4	4	NUM
admet-923	1244	4	(	(	PUNCT
admet-923	1244	5	2016	2016	NUM
admet-923	1244	6	)	)	PUNCT
admet-923	1244	7	117	117	NUM
admet-923	1244	8	.	.	PUNCT
admet-923	1245	1	https://doi.org/10.5599/admet.4.2.292	https://doi.org/10.5599/admet.4.2.292	PRON
admet-923	1245	2	.	.	PUNCT
admet-923	1246	1	[	[	X
admet-923	1246	2	112	112	NUM
admet-923	1246	3	]	]	PUNCT
admet-923	1246	4	t.	t.	NOUN
admet-923	1246	5	uekusa	uekusa	PROPN
admet-923	1246	6	,	,	PUNCT
admet-923	1246	7	k.	k.	PROPN
admet-923	1246	8	sugano	sugano	PROPN
admet-923	1246	9	.	.	PUNCT
admet-923	1247	1	effect	effect	NOUN
admet-923	1247	2	of	of	ADP
admet-923	1247	3	buffer	buffer	NOUN
admet-923	1247	4	capacity	capacity	NOUN
admet-923	1247	5	on	on	ADP
admet-923	1247	6	dissolution	dissolution	NOUN
admet-923	1247	7	and	and	CCONJ
admet-923	1247	8	supersaturation	supersaturation	NOUN
admet-923	1247	9	profiles	profile	NOUN
admet-923	1247	10	of	of	ADP
admet-923	1247	11	poorly	poorly	ADV
admet-923	1247	12	soluble	soluble	ADJ
admet-923	1247	13	drug	drug	NOUN
admet-923	1247	14	salt	salt	NOUN
admet-923	1247	15	,	,	PUNCT
admet-923	1247	16	in	in	ADP
admet-923	1247	17	:	:	PUNCT
admet-923	1247	18	apsjt	apsjt	ADJ
admet-923	1247	19	annu	annu	NOUN
admet-923	1247	20	.	.	PUNCT
admet-923	1248	1	meet	meet	PROPN
admet-923	1248	2	.	.	PROPN
admet-923	1248	3	,	,	PUNCT
admet-923	1248	4	toyama	toyama	PROPN
admet-923	1248	5	,	,	PUNCT
admet-923	1248	6	2019	2019	NUM
admet-923	1248	7	:	:	PUNCT
admet-923	1249	1	p.	p.	NOUN
admet-923	1249	2	236	236	NUM
admet-923	1249	3	.	.	PUNCT
admet-923	1250	1	[	[	X
admet-923	1250	2	113	113	NUM
admet-923	1250	3	]	]	PUNCT
admet-923	1250	4	j.	j.	PROPN
admet-923	1250	5	oki	oki	PROPN
admet-923	1250	6	,	,	PUNCT
admet-923	1250	7	d.	d.	PROPN
admet-923	1250	8	watanabe	watanabe	PROPN
admet-923	1250	9	,	,	PUNCT
admet-923	1250	10	t.	t.	PROPN
admet-923	1250	11	uekusa	uekusa	PROPN
admet-923	1250	12	,	,	PUNCT
admet-923	1250	13	k.	k.	PROPN
admet-923	1250	14	sugano	sugano	PROPN
admet-923	1250	15	.	.	PUNCT
admet-923	1251	1	mechanism	mechanism	NOUN
admet-923	1251	2	of	of	ADP
admet-923	1251	3	supersaturation	supersaturation	NOUN
admet-923	1251	4	suppression	suppression	NOUN
admet-923	1251	5	in	in	ADP
admet-923	1251	6	dissolution	dissolution	ADJ
admet-923	1251	7	process	process	NOUN
admet-923	1251	8	of	of	ADP
admet-923	1251	9	acidic	acidic	ADJ
admet-923	1251	10	drug	drug	NOUN
admet-923	1251	11	salt	salt	NOUN
admet-923	1251	12	.	.	PUNCT
admet-923	1252	1	mol	mol	PROPN
admet-923	1252	2	.	.	PUNCT
admet-923	1252	3	pharm	pharm	PROPN
admet-923	1252	4	.	.	PUNCT
admet-923	1253	1	16	16	NUM
admet-923	1253	2	(	(	PUNCT
admet-923	1253	3	2019	2019	NUM
admet-923	1253	4	)	)	PUNCT
admet-923	1253	5	1669–1677	1669–1677	NUM
admet-923	1253	6	.	.	PUNCT
admet-923	1254	1	[	[	X
admet-923	1254	2	114	114	NUM
admet-923	1254	3	]	]	PUNCT
admet-923	1254	4	k.	k.	PROPN
admet-923	1254	5	sugano	sugano	PROPN
admet-923	1254	6	.	.	PUNCT
admet-923	1255	1	a	a	DET
admet-923	1255	2	simulation	simulation	NOUN
admet-923	1255	3	of	of	ADP
admet-923	1255	4	oral	oral	ADJ
admet-923	1255	5	absorption	absorption	NOUN
admet-923	1255	6	using	use	VERB
admet-923	1255	7	classical	classical	ADJ
admet-923	1255	8	nucleation	nucleation	NOUN
admet-923	1255	9	theory	theory	NOUN
admet-923	1255	10	.	.	PUNCT
admet-923	1256	1	int	int	NOUN
admet-923	1256	2	.	.	PUNCT
admet-923	1257	1	j.	j.	PROPN
admet-923	1257	2	pharm	pharm	PROPN
admet-923	1257	3	.	.	PUNCT
admet-923	1258	1	378	378	NUM
admet-923	1258	2	(	(	PUNCT
admet-923	1258	3	2009	2009	NUM
admet-923	1258	4	)	)	PUNCT
admet-923	1258	5	142–145	142–145	NUM
admet-923	1258	6	.	.	PUNCT
admet-923	1259	1	https://doi.org/10.5599/admet.704	https://doi.org/10.5599/admet.704	X
admet-923	1259	2	https://doi.org/10.5599/admet.3.2.193	https://doi.org/10.5599/admet.3.2.193	VERB
admet-923	1259	3	https://doi.org/10.5599/admet.4.2.292	https://doi.org/10.5599/admet.4.2.292	PRON
admet-923	1259	4	admet	admet	X
admet-923	1259	5	&	&	CCONJ
admet-923	1259	6	dmpk	dmpk	PROPN
admet-923	1259	7	9(2	9(2	NUM
admet-923	1259	8	)	)	PUNCT
admet-923	1259	9	(	(	PUNCT
admet-923	1259	10	2021	2021	NUM
admet-923	1259	11	)	)	PUNCT
admet-923	1259	12	75	75	NUM
admet-923	1259	13	-	-	SYM
admet-923	1259	14	109	109	NUM
admet-923	1259	15	lost	lose	VERB
admet-923	1259	16	in	in	ADP
admet-923	1259	17	modelling	modelling	NOUN
admet-923	1259	18	and	and	CCONJ
admet-923	1259	19	simulation	simulation	NOUN
admet-923	1259	20	?	?	PUNCT
admet-923	1260	1	doi	doi	NOUN
admet-923	1260	2	:	:	PUNCT
admet-923	1260	3	https:/doi.org/10.5599	https:/doi.org/10.5599	PROPN
admet-923	1260	4	/	/	SYM
admet-923	1260	5	admet.923	admet.923	NUM
admet-923	1260	6	105	105	NUM
admet-923	1261	1	[	[	X
admet-923	1261	2	115	115	NUM
admet-923	1261	3	]	]	PUNCT
admet-923	1261	4	s.	s.	PROPN
admet-923	1261	5	ozaki	ozaki	PROPN
admet-923	1261	6	.	.	PUNCT
admet-923	1262	1	population	population	NOUN
admet-923	1262	2	balance	balance	NOUN
admet-923	1262	3	model	model	NOUN
admet-923	1262	4	for	for	ADP
admet-923	1262	5	simulation	simulation	NOUN
admet-923	1262	6	of	of	ADP
admet-923	1262	7	the	the	DET
admet-923	1262	8	supersaturation	supersaturation	NOUN
admet-923	1262	9	–	–	PUNCT
admet-923	1262	10	precipitation	precipitation	NOUN
admet-923	1262	11	behavior	behavior	NOUN
admet-923	1262	12	of	of	ADP
admet-923	1262	13	drugs	drug	NOUN
admet-923	1262	14	in	in	ADP
admet-923	1262	15	supersaturable	supersaturable	ADJ
admet-923	1262	16	solid	solid	ADJ
admet-923	1262	17	forms	form	NOUN
admet-923	1262	18	.	.	PUNCT
admet-923	1263	1	j.	j.	PROPN
admet-923	1263	2	pharm	pharm	PROPN
admet-923	1263	3	.	.	PUNCT
admet-923	1264	1	sci	sci	PROPN
admet-923	1264	2	.	.	PROPN
admet-923	1265	1	108	108	NUM
admet-923	1265	2	(	(	PUNCT
admet-923	1265	3	2019	2019	NUM
admet-923	1265	4	)	)	PUNCT
admet-923	1266	1	260–267	260–267	NUM
admet-923	1266	2	.	.	PUNCT
admet-923	1267	1	[	[	X
admet-923	1267	2	116	116	X
admet-923	1267	3	]	]	X
admet-923	1267	4	l.	l.	PROPN
admet-923	1267	5	lindfors	lindfors	PROPN
admet-923	1267	6	,	,	PUNCT
admet-923	1267	7	s.	s.	PROPN
admet-923	1267	8	forssén	forssén	PROPN
admet-923	1267	9	,	,	PUNCT
admet-923	1267	10	j.	j.	PROPN
admet-923	1267	11	westergren	westergren	PROPN
admet-923	1267	12	,	,	PUNCT
admet-923	1267	13	u.	u.	PROPN
admet-923	1267	14	olsson	olsson	PROPN
admet-923	1267	15	.	.	PUNCT
admet-923	1268	1	nucleation	nucleation	NOUN
admet-923	1268	2	and	and	CCONJ
admet-923	1268	3	crystal	crystal	NOUN
admet-923	1268	4	growth	growth	NOUN
admet-923	1268	5	in	in	ADP
admet-923	1268	6	supersaturated	supersaturated	ADJ
admet-923	1268	7	solutions	solution	NOUN
admet-923	1268	8	of	of	ADP
admet-923	1268	9	a	a	DET
admet-923	1268	10	model	model	NOUN
admet-923	1268	11	drug	drug	NOUN
admet-923	1268	12	.	.	PUNCT
admet-923	1269	1	j.	j.	PROPN
admet-923	1269	2	colloid	colloid	PROPN
admet-923	1269	3	interface	interface	PROPN
admet-923	1269	4	sci	sci	PROPN
admet-923	1269	5	.	.	PROPN
admet-923	1270	1	325	325	NUM
admet-923	1270	2	(	(	PUNCT
admet-923	1270	3	2008	2008	NUM
admet-923	1270	4	)	)	PUNCT
admet-923	1271	1	404–413	404–413	NUM
admet-923	1271	2	.	.	PUNCT
admet-923	1272	1	[	[	X
admet-923	1272	2	117	117	NUM
admet-923	1272	3	]	]	PUNCT
admet-923	1272	4	s.	s.	PROPN
admet-923	1272	5	ozaki	ozaki	PROPN
admet-923	1272	6	,	,	PUNCT
admet-923	1272	7	t.	t.	PROPN
admet-923	1272	8	minamisono	minamisono	PROPN
admet-923	1272	9	,	,	PUNCT
admet-923	1272	10	t.	t.	PROPN
admet-923	1272	11	yamashita	yamashita	PROPN
admet-923	1272	12	,	,	PUNCT
admet-923	1272	13	t.	t.	PROPN
admet-923	1272	14	kato	kato	PROPN
admet-923	1272	15	,	,	PUNCT
admet-923	1272	16	i.	i.	PROPN
admet-923	1272	17	kushida	kushida	PROPN
admet-923	1272	18	.	.	PUNCT
admet-923	1273	1	supersaturation	supersaturation	NOUN
admet-923	1273	2	--	--	PUNCT
admet-923	1273	3	nucleation	nucleation	NOUN
admet-923	1273	4	behavior	behavior	NOUN
admet-923	1273	5	of	of	ADP
admet-923	1273	6	poorly	poorly	ADV
admet-923	1273	7	soluble	soluble	ADJ
admet-923	1273	8	drugs	drug	NOUN
admet-923	1273	9	and	and	CCONJ
admet-923	1273	10	its	its	PRON
admet-923	1273	11	impact	impact	NOUN
admet-923	1273	12	on	on	ADP
admet-923	1273	13	the	the	DET
admet-923	1273	14	oral	oral	ADJ
admet-923	1273	15	absorption	absorption	NOUN
admet-923	1273	16	of	of	ADP
admet-923	1273	17	drugs	drug	NOUN
admet-923	1273	18	in	in	ADP
admet-923	1273	19	thermodynamically	thermodynamically	ADV
admet-923	1273	20	high	high	ADJ
admet-923	1273	21	-	-	PUNCT
admet-923	1273	22	energy	energy	NOUN
admet-923	1273	23	forms	form	NOUN
admet-923	1273	24	.	.	PUNCT
admet-923	1274	1	j.	j.	PROPN
admet-923	1274	2	pharm	pharm	PROPN
admet-923	1274	3	.	.	PUNCT
admet-923	1275	1	sci	sci	PROPN
admet-923	1275	2	.	.	PROPN
admet-923	1276	1	101	101	NUM
admet-923	1276	2	(	(	PUNCT
admet-923	1276	3	2012	2012	NUM
admet-923	1276	4	)	)	PUNCT
admet-923	1276	5	214–222	214–222	NUM
admet-923	1276	6	.	.	PUNCT
admet-923	1277	1	[	[	X
admet-923	1277	2	118	118	NUM
admet-923	1277	3	]	]	X
admet-923	1277	4	m.	m.	NOUN
admet-923	1277	5	warzecha	warzecha	PROPN
admet-923	1277	6	,	,	PUNCT
admet-923	1277	7	r.	r.	PROPN
admet-923	1277	8	guo	guo	PROPN
admet-923	1277	9	,	,	PUNCT
admet-923	1277	10	r.m	r.m	PROPN
admet-923	1277	11	.	.	PROPN
admet-923	1277	12	bhardwaj	bhardwaj	PROPN
admet-923	1277	13	,	,	PUNCT
admet-923	1277	14	s.m	s.m	PROPN
admet-923	1277	15	.	.	PROPN
admet-923	1277	16	reutzel	reutzel	NOUN
admet-923	1277	17	-	-	PUNCT
admet-923	1277	18	edens	eden	NOUN
admet-923	1277	19	,	,	PUNCT
admet-923	1277	20	s.l	s.l	PROPN
admet-923	1277	21	.	.	NOUN
admet-923	1277	22	price	price	NOUN
admet-923	1277	23	,	,	PUNCT
admet-923	1277	24	d.a	d.a	PROPN
admet-923	1277	25	.	.	PROPN
admet-923	1277	26	lamprou	lamprou	PROPN
admet-923	1277	27	,	,	PUNCT
admet-923	1277	28	a.j	a.j	PROPN
admet-923	1277	29	.	.	PROPN
admet-923	1277	30	florence	florence	NOUN
admet-923	1277	31	.	.	PUNCT
admet-923	1278	1	direct	direct	ADJ
admet-923	1278	2	observation	observation	NOUN
admet-923	1278	3	of	of	ADP
admet-923	1278	4	templated	template	VERB
admet-923	1278	5	two	two	NUM
admet-923	1278	6	-	-	PUNCT
admet-923	1278	7	step	step	NOUN
admet-923	1278	8	nucleation	nucleation	NOUN
admet-923	1278	9	mechanism	mechanism	NOUN
admet-923	1278	10	during	during	ADP
admet-923	1278	11	olanzapine	olanzapine	ADJ
admet-923	1278	12	hydrate	hydrate	ADJ
admet-923	1278	13	formation	formation	NOUN
admet-923	1278	14	.	.	PUNCT
admet-923	1279	1	cryst	cryst	NOUN
admet-923	1279	2	.	.	PUNCT
admet-923	1280	1	growth	growth	PROPN
admet-923	1280	2	des	des	PROPN
admet-923	1280	3	.	.	PROPN
admet-923	1280	4	17	17	NUM
admet-923	1280	5	(	(	PUNCT
admet-923	1280	6	2017	2017	NUM
admet-923	1280	7	)	)	PUNCT
admet-923	1280	8	6382–6393	6382–6393	NUM
admet-923	1280	9	.	.	PUNCT
admet-923	1281	1	[	[	X
admet-923	1281	2	119	119	NUM
admet-923	1281	3	]	]	X
admet-923	1281	4	p.	p.	PROPN
admet-923	1281	5	jakubiak	jakubiak	PROPN
admet-923	1281	6	,	,	PUNCT
admet-923	1281	7	b.	b.	PROPN
admet-923	1281	8	wagner	wagner	PROPN
admet-923	1281	9	,	,	PUNCT
admet-923	1281	10	h.p	h.p	PROPN
admet-923	1281	11	.	.	PROPN
admet-923	1281	12	grimm	grimm	PROPN
admet-923	1281	13	,	,	PUNCT
admet-923	1281	14	j.	j.	PROPN
admet-923	1281	15	petrig	petrig	PROPN
admet-923	1281	16	-	-	PUNCT
admet-923	1281	17	schaffland	schaffland	NOUN
admet-923	1281	18	,	,	PUNCT
admet-923	1281	19	f.	f.	PROPN
admet-923	1281	20	schuler	schuler	PROPN
admet-923	1281	21	,	,	PUNCT
admet-923	1281	22	r.	r.	PROPN
admet-923	1281	23	alvarez	alvarez	PROPN
admet-923	1281	24	-	-	PUNCT
admet-923	1281	25	sánchez	sánchez	PROPN
admet-923	1281	26	.	.	PUNCT
admet-923	1282	1	development	development	NOUN
admet-923	1282	2	of	of	ADP
admet-923	1282	3	a	a	DET
admet-923	1282	4	unified	unified	ADJ
admet-923	1282	5	dissolution	dissolution	NOUN
admet-923	1282	6	and	and	CCONJ
admet-923	1282	7	precipitation	precipitation	NOUN
admet-923	1282	8	model	model	NOUN
admet-923	1282	9	and	and	CCONJ
admet-923	1282	10	its	its	PRON
admet-923	1282	11	use	use	NOUN
admet-923	1282	12	for	for	ADP
admet-923	1282	13	the	the	DET
admet-923	1282	14	prediction	prediction	NOUN
admet-923	1282	15	of	of	ADP
admet-923	1282	16	oral	oral	ADJ
admet-923	1282	17	drug	drug	NOUN
admet-923	1282	18	absorption	absorption	NOUN
admet-923	1282	19	.	.	PUNCT
admet-923	1283	1	mol	mol	PROPN
admet-923	1283	2	.	.	PUNCT
admet-923	1283	3	pharm	pharm	PROPN
admet-923	1283	4	.	.	PUNCT
admet-923	1284	1	13	13	NUM
admet-923	1284	2	(	(	PUNCT
admet-923	1284	3	2016	2016	NUM
admet-923	1284	4	)	)	PUNCT
admet-923	1285	1	586–598	586–598	NUM
admet-923	1285	2	.	.	PUNCT
admet-923	1286	1	[	[	X
admet-923	1286	2	120	120	NUM
admet-923	1286	3	]	]	PUNCT
admet-923	1286	4	a.	a.	NOUN
admet-923	1286	5	llinas	llinas	PROPN
admet-923	1286	6	,	,	PUNCT
admet-923	1286	7	i.	i.	NOUN
admet-923	1286	8	oprisiu	oprisiu	PROPN
admet-923	1286	9	,	,	PUNCT
admet-923	1286	10	a.	a.	NOUN
admet-923	1286	11	avdeef	avdeef	PROPN
admet-923	1286	12	.	.	PUNCT
admet-923	1287	1	findings	finding	NOUN
admet-923	1287	2	of	of	ADP
admet-923	1287	3	the	the	DET
admet-923	1287	4	second	second	ADJ
admet-923	1287	5	challenge	challenge	NOUN
admet-923	1287	6	to	to	PART
admet-923	1287	7	predict	predict	VERB
admet-923	1287	8	aqueous	aqueous	ADJ
admet-923	1287	9	solubility	solubility	NOUN
admet-923	1287	10	.	.	PUNCT
admet-923	1288	1	j.	j.	PROPN
admet-923	1288	2	chem	chem	PROPN
admet-923	1288	3	.	.	PUNCT
admet-923	1289	1	inf	inf	PROPN
admet-923	1289	2	.	.	PROPN
admet-923	1289	3	model	model	PROPN
admet-923	1289	4	.	.	PUNCT
admet-923	1290	1	(	(	PUNCT
admet-923	1290	2	2020	2020	NUM
admet-923	1290	3	)	)	PUNCT
admet-923	1290	4	.	.	PUNCT
admet-923	1291	1	[	[	X
admet-923	1291	2	121	121	NUM
admet-923	1291	3	]	]	PUNCT
admet-923	1291	4	k.	k.	PROPN
admet-923	1291	5	takács	takács	PROPN
admet-923	1291	6	-	-	PUNCT
admet-923	1291	7	novák	novák	PROPN
admet-923	1291	8	,	,	PUNCT
admet-923	1291	9	m.	m.	NOUN
admet-923	1291	10	urac	urac	PROPN
admet-923	1291	11	,	,	PUNCT
admet-923	1291	12	p.	p.	PROPN
admet-923	1291	13	horváth	horváth	PROPN
admet-923	1291	14	,	,	PUNCT
admet-923	1291	15	g.	g.	PROPN
admet-923	1291	16	völgyi	völgyi	PROPN
admet-923	1291	17	,	,	PUNCT
admet-923	1291	18	b.d	b.d	PROPN
admet-923	1291	19	.	.	PROPN
admet-923	1291	20	anderson	anderson	PROPN
admet-923	1291	21	,	,	PUNCT
admet-923	1291	22	a.	a.	PROPN
admet-923	1291	23	avdeef	avdeef	PROPN
admet-923	1291	24	.	.	PUNCT
admet-923	1292	1	equilibrium	equilibrium	NOUN
admet-923	1292	2	solubility	solubility	NOUN
admet-923	1292	3	measurement	measurement	NOUN
admet-923	1292	4	of	of	ADP
admet-923	1292	5	compounds	compound	NOUN
admet-923	1292	6	with	with	ADP
admet-923	1292	7	low	low	ADJ
admet-923	1292	8	dissolution	dissolution	NOUN
admet-923	1292	9	rate	rate	NOUN
admet-923	1292	10	by	by	ADP
admet-923	1292	11	higuchi	higuchi	PROPN
admet-923	1292	12	’s	’s	PART
admet-923	1292	13	facilitated	facilitate	VERB
admet-923	1292	14	dissolution	dissolution	NOUN
admet-923	1292	15	method	method	NOUN
admet-923	1292	16	.	.	PUNCT
admet-923	1293	1	a	a	DET
admet-923	1293	2	validation	validation	NOUN
admet-923	1293	3	study	study	NOUN
admet-923	1293	4	.	.	PUNCT
admet-923	1294	1	eur	eur	PROPN
admet-923	1294	2	.	.	PUNCT
admet-923	1295	1	j.	j.	PROPN
admet-923	1295	2	pharm	pharm	PROPN
admet-923	1295	3	.	.	PUNCT
admet-923	1296	1	sci	sci	PROPN
admet-923	1296	2	.	.	PROPN
admet-923	1297	1	106	106	NUM
admet-923	1298	1	(	(	PUNCT
admet-923	1298	2	2017	2017	NUM
admet-923	1298	3	)	)	PUNCT
admet-923	1298	4	133–141	133–141	NUM
admet-923	1298	5	.	.	PUNCT
admet-923	1299	1	[	[	X
admet-923	1299	2	122	122	NUM
admet-923	1299	3	]	]	X
admet-923	1299	4	n.	n.	PROPN
admet-923	1299	5	sun	sun	PROPN
admet-923	1299	6	,	,	PUNCT
admet-923	1299	7	a.	a.	NOUN
admet-923	1299	8	avdeef	avdeef	PROPN
admet-923	1299	9	.	.	PUNCT
admet-923	1300	1	biorelevant	biorelevant	PROPN
admet-923	1300	2	pk	pk	PROPN
admet-923	1300	3	a	a	X
admet-923	1300	4	(	(	PUNCT
admet-923	1300	5	37	37	NUM
admet-923	1300	6	°	°	NOUN
admet-923	1300	7	c	c	NOUN
admet-923	1300	8	)	)	PUNCT
admet-923	1300	9	predicted	predict	VERB
admet-923	1300	10	from	from	ADP
admet-923	1300	11	the	the	DET
admet-923	1300	12	2d	2d	NUM
admet-923	1300	13	structure	structure	NOUN
admet-923	1300	14	of	of	ADP
admet-923	1300	15	the	the	DET
admet-923	1300	16	molecule	molecule	NOUN
admet-923	1300	17	and	and	CCONJ
admet-923	1300	18	its	its	PRON
admet-923	1300	19	pk	pk	NOUN
admet-923	1300	20	a	a	PRON
admet-923	1300	21	at	at	ADP
admet-923	1300	22	25	25	NUM
admet-923	1300	23	°	°	NOUN
admet-923	1300	24	c	c	NOUN
admet-923	1300	25	.	.	PUNCT
admet-923	1301	1	j.	j.	PROPN
admet-923	1301	2	pharm	pharm	PROPN
admet-923	1301	3	.	.	PUNCT
admet-923	1301	4	biomed	biome	VERB
admet-923	1301	5	.	.	PUNCT
admet-923	1302	1	anal	anal	ADJ
admet-923	1302	2	.	.	PUNCT
admet-923	1303	1	56	56	NUM
admet-923	1303	2	(	(	PUNCT
admet-923	1303	3	2011	2011	NUM
admet-923	1303	4	)	)	PUNCT
admet-923	1303	5	173–182	173–182	NUM
admet-923	1303	6	.	.	PUNCT
admet-923	1304	1	[	[	X
admet-923	1304	2	123	123	NUM
admet-923	1304	3	]	]	PUNCT
admet-923	1304	4	a.	a.	NOUN
admet-923	1304	5	avdeef	avdeef	PROPN
admet-923	1304	6	.	.	PUNCT
admet-923	1305	1	solubility	solubility	NOUN
admet-923	1305	2	temperature	temperature	NOUN
admet-923	1305	3	dependence	dependence	NOUN
admet-923	1305	4	predicted	predict	VERB
admet-923	1305	5	from	from	ADP
admet-923	1305	6	2d	2d	NUM
admet-923	1305	7	structure	structure	NOUN
admet-923	1305	8	.	.	PUNCT
admet-923	1306	1	admet	admet	PROPN
admet-923	1306	2	dmpk	dmpk	PROPN
admet-923	1306	3	.	.	PUNCT
admet-923	1307	1	3	3	NUM
admet-923	1307	2	(	(	PUNCT
admet-923	1307	3	2015	2015	NUM
admet-923	1307	4	)	)	PUNCT
admet-923	1308	1	298–344	298–344	NUM
admet-923	1308	2	.	.	PUNCT
admet-923	1309	1	https://doi.org/10.5599/admet.3.4.259	https://doi.org/10.5599/admet.3.4.259	NOUN
admet-923	1309	2	.	.	PUNCT
admet-923	1310	1	[	[	X
admet-923	1310	2	124	124	NUM
admet-923	1310	3	]	]	X
admet-923	1310	4	s.s	s.s	PROPN
admet-923	1310	5	.	.	PROPN
admet-923	1310	6	hate	hate	PROPN
admet-923	1310	7	,	,	PUNCT
admet-923	1310	8	s.m	s.m	PROPN
admet-923	1310	9	.	.	PROPN
admet-923	1310	10	reutzel	reutzel	NOUN
admet-923	1310	11	-	-	PUNCT
admet-923	1310	12	edens	eden	NOUN
admet-923	1310	13	,	,	PUNCT
admet-923	1310	14	l.s	l.s	PROPN
admet-923	1310	15	.	.	PROPN
admet-923	1310	16	taylor	taylor	PROPN
admet-923	1310	17	.	.	PUNCT
admet-923	1311	1	absorptive	absorptive	ADJ
admet-923	1311	2	dissolution	dissolution	NOUN
admet-923	1311	3	testing	testing	NOUN
admet-923	1311	4	of	of	ADP
admet-923	1311	5	supersaturating	supersaturate	VERB
admet-923	1311	6	systems	system	NOUN
admet-923	1311	7	:	:	PUNCT
admet-923	1311	8	impact	impact	NOUN
admet-923	1311	9	of	of	ADP
admet-923	1311	10	absorptive	absorptive	ADJ
admet-923	1311	11	sink	sink	NOUN
admet-923	1311	12	conditions	condition	NOUN
admet-923	1311	13	on	on	ADP
admet-923	1311	14	solution	solution	NOUN
admet-923	1311	15	phase	phase	NOUN
admet-923	1311	16	behavior	behavior	NOUN
admet-923	1311	17	and	and	CCONJ
admet-923	1311	18	mass	mass	NOUN
admet-923	1311	19	transport	transport	NOUN
admet-923	1311	20	.	.	PUNCT
admet-923	1312	1	mol	mol	PROPN
admet-923	1312	2	.	.	PUNCT
admet-923	1312	3	pharm	pharm	PROPN
admet-923	1312	4	.	.	PUNCT
admet-923	1313	1	14	14	NUM
admet-923	1313	2	(	(	PUNCT
admet-923	1313	3	2017	2017	NUM
admet-923	1313	4	)	)	PUNCT
admet-923	1313	5	4052–4063	4052–4063	NOUN
admet-923	1313	6	.	.	PUNCT
admet-923	1314	1	[	[	X
admet-923	1314	2	125	125	NUM
admet-923	1314	3	]	]	X
admet-923	1314	4	d.j	d.j	PROPN
admet-923	1314	5	.	.	PROPN
admet-923	1314	6	good	good	PROPN
admet-923	1314	7	,	,	PUNCT
admet-923	1314	8	r.h	r.h	PROPN
admet-923	1314	9	.	.	PROPN
admet-923	1314	10	naír	naír	PROPN
admet-923	1314	11	.	.	PUNCT
admet-923	1315	1	solubility	solubility	NOUN
admet-923	1315	2	advantage	advantage	NOUN
admet-923	1315	3	of	of	ADP
admet-923	1315	4	pharmaceutical	pharmaceutical	ADJ
admet-923	1315	5	cocrystals	cocrystal	NOUN
admet-923	1315	6	.	.	PUNCT
admet-923	1316	1	cryst	cryst	PROPN
admet-923	1316	2	.	.	PUNCT
admet-923	1317	1	growth	growth	PROPN
admet-923	1317	2	des	des	PROPN
admet-923	1317	3	.	.	PROPN
admet-923	1317	4	9	9	NUM
admet-923	1317	5	(	(	PUNCT
admet-923	1317	6	2009	2009	NUM
admet-923	1317	7	)	)	PUNCT
admet-923	1317	8	2252–2264	2252–2264	NUM
admet-923	1317	9	.	.	PUNCT
admet-923	1318	1	[	[	X
admet-923	1318	2	126	126	NUM
admet-923	1318	3	]	]	PUNCT
admet-923	1318	4	m.	m.	NOUN
admet-923	1318	5	omori	omori	PROPN
admet-923	1318	6	,	,	PUNCT
admet-923	1318	7	t.	t.	PROPN
admet-923	1318	8	watanabe	watanabe	PROPN
admet-923	1318	9	,	,	PUNCT
admet-923	1318	10	t.	t.	PROPN
admet-923	1318	11	uekusa	uekusa	PROPN
admet-923	1318	12	,	,	PUNCT
admet-923	1318	13	j.	j.	PROPN
admet-923	1318	14	oki	oki	PROPN
admet-923	1318	15	,	,	PUNCT
admet-923	1318	16	d.	d.	PROPN
admet-923	1318	17	inoue	inoue	PROPN
admet-923	1318	18	,	,	PUNCT
admet-923	1318	19	k.	k.	PROPN
admet-923	1318	20	sugano	sugano	PROPN
admet-923	1318	21	.	.	PUNCT
admet-923	1319	1	effect	effect	NOUN
admet-923	1319	2	of	of	ADP
admet-923	1319	3	coformer	coformer	NOUN
admet-923	1319	4	and	and	CCONJ
admet-923	1319	5	polymer	polymer	NOUN
admet-923	1319	6	on	on	ADP
admet-923	1319	7	particle	particle	NOUN
admet-923	1319	8	surface	surface	NOUN
admet-923	1319	9	solution	solution	NOUN
admet-923	1319	10	-	-	PUNCT
admet-923	1319	11	mediated	mediate	VERB
admet-923	1319	12	phase	phase	NOUN
admet-923	1319	13	transformation	transformation	NOUN
admet-923	1319	14	of	of	ADP
admet-923	1319	15	cocrystal	cocrystal	NOUN
admet-923	1319	16	in	in	ADP
admet-923	1319	17	aqueous	aqueous	ADJ
admet-923	1319	18	media	medium	NOUN
admet-923	1319	19	.	.	PUNCT
admet-923	1320	1	mol	mol	PROPN
admet-923	1320	2	.	.	PUNCT
admet-923	1320	3	pharm	pharm	PROPN
admet-923	1320	4	.	.	PUNCT
admet-923	1321	1	(	(	PUNCT
admet-923	1321	2	2020	2020	NUM
admet-923	1321	3	)	)	PUNCT
admet-923	1321	4	.	.	PUNCT
admet-923	1322	1	[	[	X
admet-923	1322	2	127	127	NUM
admet-923	1322	3	]	]	X
admet-923	1322	4	b.	b.	PROPN
admet-923	1322	5	van	van	PROPN
admet-923	1322	6	eerdenbrugh	eerdenbrugh	PROPN
admet-923	1322	7	,	,	PUNCT
admet-923	1322	8	g.	g.	PROPN
admet-923	1322	9	van	van	PROPN
admet-923	1322	10	den	den	PROPN
admet-923	1322	11	mooter	mooter	NOUN
admet-923	1322	12	,	,	PUNCT
admet-923	1322	13	p.	p.	NOUN
admet-923	1322	14	augustijns	augustijns	NOUN
admet-923	1322	15	,	,	PUNCT
admet-923	1322	16	j.	j.	PROPN
admet-923	1322	17	vermant	vermant	PROPN
admet-923	1322	18	,	,	PUNCT
admet-923	1322	19	j.a	j.a	PROPN
admet-923	1322	20	.	.	PROPN
admet-923	1322	21	martens	martens	PROPN
admet-923	1322	22	,	,	PUNCT
admet-923	1322	23	l.	l.	PROPN
admet-923	1322	24	froyen	froyen	PROPN
admet-923	1322	25	,	,	PUNCT
admet-923	1322	26	j.	j.	PROPN
admet-923	1322	27	van	van	PROPN
admet-923	1322	28	humbeeck	humbeeck	PROPN
admet-923	1322	29	.	.	PUNCT
admet-923	1323	1	solubility	solubility	NOUN
admet-923	1323	2	increases	increase	NOUN
admet-923	1323	3	associated	associate	VERB
admet-923	1323	4	with	with	ADP
admet-923	1323	5	crystalline	crystalline	ADJ
admet-923	1323	6	drug	drug	NOUN
admet-923	1323	7	nanoparticles	nanoparticle	NOUN
admet-923	1323	8	:	:	PUNCT
admet-923	1323	9	methodologies	methodology	NOUN
admet-923	1323	10	and	and	CCONJ
admet-923	1323	11	significance	significance	NOUN
admet-923	1323	12	.	.	PUNCT
admet-923	1324	1	mol	mol	X
admet-923	1324	2	.	.	PUNCT
admet-923	1324	3	pharm	pharm	PROPN
admet-923	1324	4	.	.	PUNCT
admet-923	1325	1	7	7	NUM
admet-923	1325	2	(	(	PUNCT
admet-923	1325	3	2010	2010	NUM
admet-923	1325	4	)	)	PUNCT
admet-923	1325	5	1858–1870	1858–1870	NUM
admet-923	1325	6	.	.	PUNCT
admet-923	1326	1	[	[	X
admet-923	1326	2	128	128	NUM
admet-923	1326	3	]	]	X
admet-923	1326	4	s.b	s.b	PROPN
admet-923	1326	5	.	.	PROPN
admet-923	1326	6	murdande	murdande	PROPN
admet-923	1326	7	,	,	PUNCT
admet-923	1326	8	d.a	d.a	PROPN
admet-923	1326	9	.	.	PROPN
admet-923	1326	10	shah	shah	PROPN
admet-923	1326	11	,	,	PUNCT
admet-923	1326	12	r.h	r.h	PROPN
admet-923	1326	13	.	.	PROPN
admet-923	1326	14	dave	dave	PROPN
admet-923	1326	15	.	.	PUNCT
admet-923	1327	1	impact	impact	NOUN
admet-923	1327	2	of	of	ADP
admet-923	1327	3	nanosizing	nanosizing	NOUN
admet-923	1327	4	on	on	ADP
admet-923	1327	5	solubility	solubility	NOUN
admet-923	1327	6	and	and	CCONJ
admet-923	1327	7	dissolution	dissolution	NOUN
admet-923	1327	8	rate	rate	NOUN
admet-923	1327	9	of	of	ADP
admet-923	1327	10	poorly	poorly	ADV
admet-923	1327	11	soluble	soluble	ADJ
admet-923	1327	12	pharmaceuticals	pharmaceutical	NOUN
admet-923	1327	13	.	.	PUNCT
admet-923	1328	1	j.	j.	PROPN
admet-923	1328	2	pharm	pharm	PROPN
admet-923	1328	3	.	.	PUNCT
admet-923	1329	1	sci	sci	PROPN
admet-923	1329	2	.	.	PROPN
admet-923	1330	1	104	104	NUM
admet-923	1330	2	(	(	PUNCT
admet-923	1330	3	2015	2015	NUM
admet-923	1330	4	)	)	PUNCT
admet-923	1330	5	2094–2102	2094–2102	NUM
admet-923	1330	6	.	.	PUNCT
admet-923	1331	1	[	[	X
admet-923	1331	2	129	129	NUM
admet-923	1331	3	]	]	PUNCT
admet-923	1331	4	k.	k.	PROPN
admet-923	1331	5	sugano	sugano	PROPN
admet-923	1331	6	.	.	PUNCT
admet-923	1332	1	possible	possible	ADJ
admet-923	1332	2	reduction	reduction	NOUN
admet-923	1332	3	of	of	ADP
admet-923	1332	4	effective	effective	ADJ
admet-923	1332	5	thickness	thickness	NOUN
admet-923	1332	6	of	of	ADP
admet-923	1332	7	intestinal	intestinal	ADJ
admet-923	1332	8	unstirred	unstirred	ADJ
admet-923	1332	9	water	water	NOUN
admet-923	1332	10	layer	layer	NOUN
admet-923	1332	11	by	by	ADP
admet-923	1332	12	particle	particle	NOUN
admet-923	1332	13	drifting	drift	VERB
admet-923	1332	14	effect	effect	NOUN
admet-923	1332	15	.	.	PUNCT
admet-923	1333	1	int	int	NOUN
admet-923	1333	2	.	.	PUNCT
admet-923	1334	1	j.	j.	PROPN
admet-923	1334	2	pharm	pharm	PROPN
admet-923	1334	3	.	.	PUNCT
admet-923	1335	1	387	387	NUM
admet-923	1335	2	(	(	PUNCT
admet-923	1335	3	2010	2010	NUM
admet-923	1335	4	)	)	PUNCT
admet-923	1335	5	.	.	PUNCT
admet-923	1336	1	[	[	X
admet-923	1336	2	130	130	NUM
admet-923	1336	3	]	]	X
admet-923	1336	4	j.f	j.f	PROPN
admet-923	1336	5	.	.	PROPN
admet-923	1336	6	cuine	cuine	PROPN
admet-923	1336	7	,	,	PUNCT
admet-923	1336	8	c.l	c.l	PROPN
admet-923	1336	9	.	.	PROPN
admet-923	1336	10	mcevoy	mcevoy	PROPN
admet-923	1336	11	,	,	PUNCT
admet-923	1336	12	w.n	w.n	PROPN
admet-923	1336	13	.	.	PROPN
admet-923	1336	14	charman	charman	PROPN
admet-923	1336	15	,	,	PUNCT
admet-923	1336	16	c.w	c.w	PROPN
admet-923	1336	17	.	.	PROPN
admet-923	1336	18	pouton	pouton	PROPN
admet-923	1336	19	,	,	PUNCT
admet-923	1336	20	g.a	g.a	PROPN
admet-923	1336	21	.	.	PROPN
admet-923	1336	22	edwards	edwards	PROPN
admet-923	1336	23	,	,	PUNCT
admet-923	1336	24	h.	h.	PROPN
admet-923	1336	25	benameur	benameur	PROPN
admet-923	1336	26	,	,	PUNCT
admet-923	1336	27	c.j.h	c.j.h	ADJ
admet-923	1336	28	.	.	PUNCT
admet-923	1336	29	porter	porter	NOUN
admet-923	1336	30	.	.	PUNCT
admet-923	1337	1	evaluation	evaluation	NOUN
admet-923	1337	2	of	of	ADP
admet-923	1337	3	the	the	DET
admet-923	1337	4	impact	impact	NOUN
admet-923	1337	5	of	of	ADP
admet-923	1337	6	surfactant	surfactant	ADJ
admet-923	1337	7	digestion	digestion	NOUN
admet-923	1337	8	on	on	ADP
admet-923	1337	9	the	the	DET
admet-923	1337	10	bioavailability	bioavailability	NOUN
admet-923	1337	11	of	of	ADP
admet-923	1337	12	danazol	danazol	ADJ
admet-923	1337	13	after	after	ADP
admet-923	1337	14	oral	oral	ADJ
admet-923	1337	15	administration	administration	NOUN
admet-923	1337	16	of	of	ADP
admet-923	1337	17	lipidic	lipidic	ADJ
admet-923	1337	18	self	self	NOUN
admet-923	1337	19	-	-	PUNCT
admet-923	1337	20	emulsifying	emulsify	VERB
admet-923	1337	21	formulations	formulation	NOUN
admet-923	1337	22	to	to	ADP
admet-923	1337	23	dogs	dog	NOUN
admet-923	1337	24	.	.	PUNCT
admet-923	1338	1	j.	j.	PROPN
admet-923	1338	2	pharm	pharm	PROPN
admet-923	1338	3	.	.	PUNCT
admet-923	1339	1	sci	sci	PROPN
admet-923	1339	2	.	.	PROPN
admet-923	1339	3	97	97	NUM
admet-923	1339	4	(	(	PUNCT
admet-923	1339	5	2008	2008	NUM
admet-923	1339	6	)	)	PUNCT
admet-923	1339	7	995–1012	995–1012	NUM
admet-923	1339	8	.	.	PUNCT
admet-923	1340	1	[	[	X
admet-923	1340	2	131	131	NUM
admet-923	1340	3	]	]	X
admet-923	1340	4	a.t	a.t	PROPN
admet-923	1340	5	.	.	PROPN
admet-923	1340	6	larsen	larsen	PROPN
admet-923	1340	7	,	,	PUNCT
admet-923	1340	8	p.	p.	PROPN
admet-923	1340	9	sassene	sassene	PROPN
admet-923	1340	10	,	,	PUNCT
admet-923	1340	11	a.	a.	NOUN
admet-923	1340	12	müllertz	müllertz	NOUN
admet-923	1340	13	.	.	PUNCT
admet-923	1341	1	in	in	ADP
admet-923	1341	2	vitro	vitro	X
admet-923	1341	3	lipolysis	lipolysis	NOUN
admet-923	1341	4	models	model	NOUN
admet-923	1341	5	as	as	ADP
admet-923	1341	6	a	a	DET
admet-923	1341	7	tool	tool	NOUN
admet-923	1341	8	for	for	ADP
admet-923	1341	9	the	the	DET
admet-923	1341	10	characterization	characterization	NOUN
admet-923	1341	11	of	of	ADP
admet-923	1341	12	oral	oral	ADJ
admet-923	1341	13	lipid	lipid	NOUN
admet-923	1341	14	and	and	CCONJ
admet-923	1341	15	surfactant	surfactant	NOUN
admet-923	1341	16	based	base	VERB
admet-923	1341	17	drug	drug	NOUN
admet-923	1341	18	delivery	delivery	NOUN
admet-923	1341	19	systems	system	NOUN
admet-923	1341	20	.	.	PUNCT
admet-923	1342	1	int	int	NOUN
admet-923	1342	2	.	.	PUNCT
admet-923	1343	1	j.	j.	PROPN
admet-923	1343	2	pharm	pharm	PROPN
admet-923	1343	3	.	.	PUNCT
admet-923	1344	1	417	417	NUM
admet-923	1344	2	(	(	PUNCT
admet-923	1344	3	2011	2011	NUM
admet-923	1344	4	)	)	PUNCT
admet-923	1344	5	245–255	245–255	NUM
admet-923	1344	6	.	.	PUNCT
admet-923	1345	1	[	[	X
admet-923	1345	2	132	132	NUM
admet-923	1345	3	]	]	X
admet-923	1345	4	d.	d.	NOUN
admet-923	1345	5	orrell	orrell	PROPN
admet-923	1345	6	.	.	PUNCT
admet-923	1346	1	apollo	apollo	PROPN
admet-923	1346	2	’s	’s	PART
admet-923	1346	3	arrow	arrow	NOUN
admet-923	1346	4	,	,	PUNCT
admet-923	1346	5	harpercollins	harpercollin	NOUN
admet-923	1346	6	,	,	PUNCT
admet-923	1346	7	2008	2008	NUM
admet-923	1346	8	.	.	PUNCT
admet-923	1347	1	[	[	X
admet-923	1347	2	133	133	NUM
admet-923	1347	3	]	]	X
admet-923	1347	4	s.a	s.a	PROPN
admet-923	1347	5	.	.	PROPN
admet-923	1347	6	peters	peters	PROPN
admet-923	1347	7	,	,	PUNCT
admet-923	1347	8	p.e	p.e	PROPN
admet-923	1347	9	.	.	PROPN
admet-923	1347	10	schroeder	schroeder	PROPN
admet-923	1347	11	,	,	PUNCT
admet-923	1347	12	n.	n.	PROPN
admet-923	1347	13	giri	giri	PROPN
admet-923	1347	14	,	,	PUNCT
admet-923	1347	15	h.	h.	PROPN
admet-923	1347	16	dolgos	dolgos	PROPN
admet-923	1347	17	.	.	PUNCT
admet-923	1348	1	evaluation	evaluation	NOUN
admet-923	1348	2	of	of	ADP
admet-923	1348	3	the	the	DET
admet-923	1348	4	use	use	NOUN
admet-923	1348	5	of	of	ADP
admet-923	1348	6	static	static	ADJ
admet-923	1348	7	and	and	CCONJ
admet-923	1348	8	dynamic	dynamic	ADJ
admet-923	1348	9	models	model	NOUN
admet-923	1348	10	to	to	PART
admet-923	1348	11	predict	predict	VERB
admet-923	1348	12	drug	drug	NOUN
admet-923	1348	13	-	-	PUNCT
admet-923	1348	14	drug	drug	NOUN
admet-923	1348	15	interaction	interaction	NOUN
admet-923	1348	16	and	and	CCONJ
admet-923	1348	17	its	its	PRON
admet-923	1348	18	associated	associated	ADJ
admet-923	1348	19	variability	variability	NOUN
admet-923	1348	20	:	:	PUNCT
admet-923	1348	21	impact	impact	NOUN
admet-923	1348	22	on	on	ADP
admet-923	1348	23	drug	drug	NOUN
admet-923	1348	24	discovery	discovery	NOUN
admet-923	1348	25	and	and	CCONJ
admet-923	1348	26	early	early	ADJ
admet-923	1348	27	development	development	NOUN
admet-923	1348	28	.	.	PUNCT
admet-923	1349	1	drug	drug	NOUN
admet-923	1349	2	metab	metab	PROPN
admet-923	1349	3	.	.	PUNCT
admet-923	1350	1	dispos	dispos	PROPN
admet-923	1350	2	.	.	PUNCT
admet-923	1351	1	40	40	NUM
admet-923	1351	2	(	(	PUNCT
admet-923	1351	3	2012	2012	NUM
admet-923	1351	4	)	)	PUNCT
admet-923	1351	5	1495–1507	1495–1507	NUM
admet-923	1351	6	.	.	PUNCT
admet-923	1352	1	[	[	X
admet-923	1352	2	134	134	NUM
admet-923	1352	3	]	]	X
admet-923	1352	4	j.b	j.b	PROPN
admet-923	1352	5	.	.	PROPN
admet-923	1352	6	dressman	dressman	PROPN
admet-923	1352	7	,	,	PUNCT
admet-923	1352	8	d.	d.	PROPN
admet-923	1352	9	fleisher	fleisher	PROPN
admet-923	1352	10	.	.	PUNCT
admet-923	1353	1	mixing	mix	VERB
admet-923	1353	2	-	-	PUNCT
admet-923	1353	3	tank	tank	NOUN
admet-923	1353	4	model	model	NOUN
admet-923	1353	5	for	for	ADP
admet-923	1353	6	predicting	predict	VERB
admet-923	1353	7	dissolution	dissolution	NOUN
admet-923	1353	8	rate	rate	NOUN
admet-923	1353	9	control	control	NOUN
admet-923	1353	10	of	of	ADP
admet-923	1353	11	oral	oral	ADJ
admet-923	1353	12	absorption	absorption	NOUN
admet-923	1353	13	.	.	PUNCT
admet-923	1354	1	j.	j.	PROPN
admet-923	1354	2	pharm	pharm	PROPN
admet-923	1354	3	.	.	PUNCT
admet-923	1355	1	sci	sci	PROPN
admet-923	1355	2	.	.	PROPN
admet-923	1356	1	75	75	NUM
admet-923	1356	2	(	(	PUNCT
admet-923	1356	3	1986	1986	NUM
admet-923	1356	4	)	)	PUNCT
admet-923	1357	1	109–116	109–116	NUM
admet-923	1357	2	.	.	PUNCT
admet-923	1358	1	https://doi.org/10.5599/admet.923	https://doi.org/10.5599/admet.923	X
admet-923	1359	1	https://doi.org/10.5599/admet.3.4.259	https://doi.org/10.5599/admet.3.4.259	NOUN
admet-923	1359	2	kiyohiko	kiyohiko	VERB
admet-923	1359	3	sugano	sugano	PROPN
admet-923	1359	4	admet	admet	PROPN
admet-923	1359	5	&	&	CCONJ
admet-923	1359	6	dmpk	dmpk	PROPN
admet-923	1359	7	9(2	9(2	NUM
admet-923	1359	8	)	)	PUNCT
admet-923	1359	9	(	(	PUNCT
admet-923	1359	10	2021	2021	NUM
admet-923	1359	11	)	)	PUNCT
admet-923	1359	12	75	75	NUM
admet-923	1359	13	-	-	SYM
admet-923	1359	14	109	109	NUM
admet-923	1359	15	106	106	NUM
admet-923	1359	16	[	[	X
admet-923	1359	17	135	135	NUM
admet-923	1359	18	]	]	X
admet-923	1359	19	e.	e.	PROPN
admet-923	1359	20	nicolaides	nicolaides	PROPN
admet-923	1359	21	,	,	PUNCT
admet-923	1359	22	m.	m.	NOUN
admet-923	1359	23	symillides	symillide	NOUN
admet-923	1359	24	,	,	PUNCT
admet-923	1360	1	j.b	j.b	PROPN
admet-923	1360	2	.	.	PROPN
admet-923	1360	3	dressman	dressman	PROPN
admet-923	1360	4	,	,	PUNCT
admet-923	1360	5	c.	c.	PROPN
admet-923	1360	6	reppas	reppas	PROPN
admet-923	1360	7	.	.	PUNCT
admet-923	1361	1	biorelevant	biorelevant	ADJ
admet-923	1361	2	dissolution	dissolution	PROPN
admet-923	1361	3	testing	testing	NOUN
admet-923	1361	4	to	to	PART
admet-923	1361	5	predict	predict	VERB
admet-923	1361	6	the	the	DET
admet-923	1361	7	plasma	plasma	NOUN
admet-923	1361	8	profile	profile	NOUN
admet-923	1361	9	of	of	ADP
admet-923	1361	10	lipophilic	lipophilic	ADJ
admet-923	1361	11	drugs	drug	NOUN
admet-923	1361	12	after	after	ADP
admet-923	1361	13	oral	oral	ADJ
admet-923	1361	14	administration	administration	NOUN
admet-923	1361	15	.	.	PUNCT
admet-923	1362	1	pharm	pharm	PROPN
admet-923	1362	2	.	.	PUNCT
admet-923	1363	1	res	re	NOUN
admet-923	1363	2	.	.	PROPN
admet-923	1364	1	18	18	NUM
admet-923	1364	2	(	(	PUNCT
admet-923	1364	3	2001	2001	NUM
admet-923	1364	4	)	)	PUNCT
admet-923	1365	1	380–388	380–388	NUM
admet-923	1365	2	.	.	PUNCT
admet-923	1366	1	[	[	X
admet-923	1366	2	136	136	NUM
admet-923	1366	3	]	]	X
admet-923	1366	4	c.	c.	PROPN
admet-923	1366	5	wagner	wagner	PROPN
admet-923	1366	6	,	,	PUNCT
admet-923	1366	7	e.	e.	PROPN
admet-923	1366	8	jantratid	jantratid	PROPN
admet-923	1366	9	,	,	PUNCT
admet-923	1366	10	f.	f.	PROPN
admet-923	1366	11	kesisoglou	kesisoglou	PROPN
admet-923	1366	12	,	,	PUNCT
admet-923	1366	13	m.	m.	NOUN
admet-923	1366	14	vertzoni	vertzoni	PROPN
admet-923	1366	15	,	,	PUNCT
admet-923	1366	16	c.	c.	PROPN
admet-923	1366	17	reppas	reppas	PROPN
admet-923	1366	18	,	,	PUNCT
admet-923	1366	19	j.	j.	PROPN
admet-923	1366	20	b.	b.	PROPN
admet-923	1366	21	dressman	dressman	PROPN
admet-923	1366	22	.	.	PUNCT
admet-923	1366	23	predicting	predict	VERB
admet-923	1366	24	the	the	DET
admet-923	1366	25	oral	oral	ADJ
admet-923	1366	26	absorption	absorption	NOUN
admet-923	1366	27	of	of	ADP
admet-923	1366	28	a	a	DET
admet-923	1366	29	poorly	poorly	ADV
admet-923	1366	30	soluble	soluble	ADJ
admet-923	1366	31	,	,	PUNCT
admet-923	1366	32	poorly	poorly	ADV
admet-923	1366	33	permeable	permeable	ADJ
admet-923	1366	34	weak	weak	ADJ
admet-923	1366	35	base	base	NOUN
admet-923	1366	36	using	use	VERB
admet-923	1366	37	biorelevant	biorelevant	NOUN
admet-923	1366	38	dissolution	dissolution	NOUN
admet-923	1366	39	and	and	CCONJ
admet-923	1366	40	transfer	transfer	NOUN
admet-923	1366	41	model	model	NOUN
admet-923	1366	42	tests	test	NOUN
admet-923	1366	43	coupled	couple	VERB
admet-923	1366	44	with	with	ADP
admet-923	1366	45	a	a	DET
admet-923	1366	46	physiologically	physiologically	ADV
admet-923	1366	47	based	base	VERB
admet-923	1366	48	pharmacokinetic	pharmacokinetic	ADJ
admet-923	1366	49	model	model	NOUN
admet-923	1366	50	.	.	PUNCT
admet-923	1367	1	eur	eur	PROPN
admet-923	1367	2	.	.	PUNCT
admet-923	1368	1	j.	j.	PROPN
admet-923	1368	2	pharm	pharm	PROPN
admet-923	1368	3	.	.	PUNCT
admet-923	1369	1	biopharm	biopharm	PROPN
admet-923	1369	2	.	.	PUNCT
admet-923	1370	1	82	82	NUM
admet-923	1370	2	(	(	PUNCT
admet-923	1370	3	2012	2012	NUM
admet-923	1370	4	)	)	PUNCT
admet-923	1371	1	127–138	127–138	NUM
admet-923	1371	2	.	.	PUNCT
admet-923	1372	1	[	[	X
admet-923	1372	2	137	137	NUM
admet-923	1372	3	]	]	PUNCT
admet-923	1372	4	s.	s.	PROPN
admet-923	1372	5	chakraborty	chakraborty	PROPN
admet-923	1372	6	,	,	PUNCT
admet-923	1372	7	l.	l.	PROPN
admet-923	1372	8	yadav	yadav	PROPN
admet-923	1372	9	,	,	PUNCT
admet-923	1372	10	d.	d.	PROPN
admet-923	1372	11	aggarwal	aggarwal	PROPN
admet-923	1372	12	.	.	PUNCT
admet-923	1373	1	prediction	prediction	NOUN
admet-923	1373	2	of	of	ADP
admet-923	1373	3	in	in	ADP
admet-923	1373	4	vivo	vivo	ADJ
admet-923	1373	5	drug	drug	NOUN
admet-923	1373	6	performance	performance	NOUN
admet-923	1373	7	using	use	VERB
admet-923	1373	8	in	in	ADP
admet-923	1373	9	vitro	vitro	X
admet-923	1373	10	dissolution	dissolution	NOUN
admet-923	1373	11	coupled	couple	VERB
admet-923	1373	12	with	with	ADP
admet-923	1373	13	stella	stella	PROPN
admet-923	1373	14	:	:	PUNCT
admet-923	1373	15	a	a	DET
admet-923	1373	16	study	study	NOUN
admet-923	1373	17	with	with	ADP
admet-923	1373	18	selected	select	VERB
admet-923	1373	19	drug	drug	NOUN
admet-923	1373	20	products	product	NOUN
admet-923	1373	21	.	.	PUNCT
admet-923	1374	1	drug	drug	PROPN
admet-923	1374	2	dev	dev	PROPN
admet-923	1374	3	.	.	PUNCT
admet-923	1375	1	ind	ind	PROPN
admet-923	1375	2	.	.	PUNCT
admet-923	1376	1	pharm	pharm	PROPN
admet-923	1376	2	.	.	PUNCT
admet-923	1377	1	41	41	NUM
admet-923	1377	2	(	(	PUNCT
admet-923	1377	3	2015	2015	NUM
admet-923	1377	4	)	)	PUNCT
admet-923	1377	5	1667–1673	1667–1673	NUM
admet-923	1377	6	.	.	PUNCT
admet-923	1378	1	[	[	X
admet-923	1378	2	138	138	NUM
admet-923	1378	3	]	]	PUNCT
admet-923	1378	4	a.	a.	NOUN
admet-923	1378	5	kambayashi	kambayashi	PROPN
admet-923	1378	6	,	,	PUNCT
admet-923	1378	7	t.	t.	PROPN
admet-923	1378	8	yasuji	yasuji	PROPN
admet-923	1378	9	,	,	PUNCT
admet-923	1378	10	j.b	j.b	PROPN
admet-923	1378	11	.	.	PROPN
admet-923	1378	12	dressman	dressman	PROPN
admet-923	1378	13	.	.	PUNCT
admet-923	1379	1	prediction	prediction	NOUN
admet-923	1379	2	of	of	ADP
admet-923	1379	3	the	the	DET
admet-923	1379	4	precipitation	precipitation	NOUN
admet-923	1379	5	profiles	profile	NOUN
admet-923	1379	6	of	of	ADP
admet-923	1379	7	weak	weak	ADJ
admet-923	1379	8	base	base	NOUN
admet-923	1379	9	drugs	drug	NOUN
admet-923	1379	10	in	in	ADP
admet-923	1379	11	the	the	DET
admet-923	1379	12	small	small	ADJ
admet-923	1379	13	intestine	intestine	NOUN
admet-923	1379	14	using	use	VERB
admet-923	1379	15	a	a	DET
admet-923	1379	16	simplified	simplified	ADJ
admet-923	1379	17	transfer	transfer	NOUN
admet-923	1379	18	(	(	PUNCT
admet-923	1379	19	“	"	PUNCT
admet-923	1379	20	dumping	dump	VERB
admet-923	1379	21	”	"	PUNCT
admet-923	1379	22	)	)	PUNCT
admet-923	1379	23	model	model	NOUN
admet-923	1379	24	coupled	couple	VERB
admet-923	1379	25	with	with	ADP
admet-923	1379	26	in	in	ADP
admet-923	1379	27	silico	silico	NOUN
admet-923	1379	28	modeling	modeling	NOUN
admet-923	1379	29	and	and	CCONJ
admet-923	1379	30	simulation	simulation	NOUN
admet-923	1379	31	approach	approach	NOUN
admet-923	1379	32	.	.	PUNCT
admet-923	1380	1	eur	eur	PROPN
admet-923	1380	2	.	.	PUNCT
admet-923	1381	1	j.	j.	PROPN
admet-923	1381	2	pharm	pharm	PROPN
admet-923	1381	3	.	.	PUNCT
admet-923	1382	1	biopharm	biopharm	PROPN
admet-923	1382	2	.	.	PUNCT
admet-923	1383	1	103	103	NUM
admet-923	1383	2	(	(	PUNCT
admet-923	1383	3	2016	2016	NUM
admet-923	1383	4	)	)	PUNCT
admet-923	1383	5	95–103	95–103	NUM
admet-923	1383	6	.	.	PUNCT
admet-923	1384	1	[	[	X
admet-923	1384	2	139	139	NUM
admet-923	1384	3	]	]	PUNCT
admet-923	1384	4	a.	a.	NOUN
admet-923	1384	5	kambayashi	kambayashi	PROPN
admet-923	1384	6	,	,	PUNCT
admet-923	1384	7	j.b	j.b	PROPN
admet-923	1384	8	.	.	PROPN
admet-923	1384	9	dressman	dressman	PROPN
admet-923	1384	10	.	.	PUNCT
admet-923	1385	1	forecasting	forecast	VERB
admet-923	1385	2	gastrointestinal	gastrointestinal	ADJ
admet-923	1385	3	precipitation	precipitation	NOUN
admet-923	1385	4	and	and	CCONJ
admet-923	1385	5	oral	oral	ADJ
admet-923	1385	6	pharmacokinetics	pharmacokinetic	NOUN
admet-923	1385	7	of	of	ADP
admet-923	1385	8	dantrolene	dantrolene	NOUN
admet-923	1385	9	in	in	ADP
admet-923	1385	10	dogs	dog	NOUN
admet-923	1385	11	using	use	VERB
admet-923	1385	12	an	an	DET
admet-923	1385	13	in	in	ADV
admet-923	1385	14	vitro	vitro	X
admet-923	1385	15	precipitation	precipitation	NOUN
admet-923	1385	16	testing	testing	NOUN
admet-923	1385	17	coupled	couple	VERB
admet-923	1385	18	with	with	ADP
admet-923	1385	19	in	in	ADP
admet-923	1385	20	silico	silico	NOUN
admet-923	1385	21	modeling	modeling	NOUN
admet-923	1385	22	and	and	CCONJ
admet-923	1385	23	simulation	simulation	NOUN
admet-923	1385	24	.	.	PUNCT
admet-923	1386	1	eur	eur	PROPN
admet-923	1386	2	.	.	PUNCT
admet-923	1387	1	j.	j.	PROPN
admet-923	1387	2	pharm	pharm	PROPN
admet-923	1387	3	.	.	PUNCT
admet-923	1388	1	biopharm	biopharm	PROPN
admet-923	1388	2	.	.	PUNCT
admet-923	1389	1	119	119	NUM
admet-923	1389	2	(	(	PUNCT
admet-923	1389	3	2017	2017	NUM
admet-923	1389	4	)	)	PUNCT
admet-923	1389	5	107–113	107–113	NUM
admet-923	1389	6	.	.	PUNCT
admet-923	1390	1	[	[	X
admet-923	1390	2	140	140	NUM
admet-923	1390	3	]	]	PUNCT
admet-923	1390	4	a.	a.	NOUN
admet-923	1390	5	kambayashi	kambayashi	PROPN
admet-923	1390	6	,	,	PUNCT
admet-923	1390	7	j.b	j.b	PROPN
admet-923	1390	8	.	.	PROPN
admet-923	1390	9	dressman	dressman	PROPN
admet-923	1390	10	.	.	PUNCT
admet-923	1391	1	an	an	DET
admet-923	1391	2	in	in	ADP
admet-923	1391	3	vitro	vitro	NOUN
admet-923	1391	4	-	-	PUNCT
admet-923	1391	5	in	in	ADP
admet-923	1391	6	silico	silico	NOUN
admet-923	1391	7	-	-	PUNCT
admet-923	1391	8	in	in	ADP
admet-923	1391	9	vivo	vivo	NOUN
admet-923	1391	10	approach	approach	NOUN
admet-923	1391	11	to	to	ADP
admet-923	1391	12	predicting	predict	VERB
admet-923	1391	13	the	the	DET
admet-923	1391	14	oral	oral	ADJ
admet-923	1391	15	pharmacokinetic	pharmacokinetic	ADJ
admet-923	1391	16	profile	profile	NOUN
admet-923	1391	17	of	of	ADP
admet-923	1391	18	salts	salt	NOUN
admet-923	1391	19	of	of	ADP
admet-923	1391	20	weak	weak	ADJ
admet-923	1391	21	acids	acid	NOUN
admet-923	1391	22	:	:	PUNCT
admet-923	1391	23	case	case	NOUN
admet-923	1391	24	example	example	NOUN
admet-923	1391	25	dantrolene	dantrolene	PROPN
admet-923	1391	26	.	.	PUNCT
admet-923	1392	1	eur	eur	PROPN
admet-923	1392	2	.	.	PUNCT
admet-923	1393	1	j.	j.	PROPN
admet-923	1393	2	pharm	pharm	PROPN
admet-923	1393	3	.	.	PUNCT
admet-923	1394	1	biopharm	biopharm	PROPN
admet-923	1394	2	.	.	PUNCT
admet-923	1395	1	84	84	NUM
admet-923	1395	2	(	(	PUNCT
admet-923	1395	3	2013	2013	NUM
admet-923	1395	4	)	)	PUNCT
admet-923	1395	5	200–207	200–207	NUM
admet-923	1395	6	.	.	PUNCT
admet-923	1396	1	[	[	X
admet-923	1396	2	141	141	NUM
admet-923	1396	3	]	]	PUNCT
admet-923	1396	4	k.	k.	PROPN
admet-923	1396	5	matsui	matsui	PROPN
admet-923	1396	6	,	,	PUNCT
admet-923	1396	7	y.	y.	PROPN
admet-923	1396	8	tsume	tsume	PROPN
admet-923	1396	9	,	,	PUNCT
admet-923	1396	10	s.	s.	PROPN
admet-923	1396	11	takeuchi	takeuchi	PROPN
admet-923	1396	12	,	,	PUNCT
admet-923	1396	13	a.	a.	NOUN
admet-923	1396	14	searls	searls	PROPN
admet-923	1396	15	,	,	PUNCT
admet-923	1396	16	g.l	g.l	PROPN
admet-923	1396	17	.	.	PROPN
admet-923	1396	18	amidon	amidon	PROPN
admet-923	1396	19	.	.	PUNCT
admet-923	1397	1	utilization	utilization	NOUN
admet-923	1397	2	of	of	ADP
admet-923	1397	3	gastrointestinal	gastrointestinal	ADJ
admet-923	1397	4	simulator	simulator	NOUN
admet-923	1397	5	,	,	PUNCT
admet-923	1397	6	an	an	DET
admet-923	1397	7	in	in	ADP
admet-923	1397	8	vivo	vivo	ADJ
admet-923	1397	9	predictive	predictive	ADJ
admet-923	1397	10	dissolution	dissolution	NOUN
admet-923	1397	11	methodology	methodology	NOUN
admet-923	1397	12	,	,	PUNCT
admet-923	1397	13	coupled	couple	VERB
admet-923	1397	14	with	with	ADP
admet-923	1397	15	computational	computational	ADJ
admet-923	1397	16	approach	approach	NOUN
admet-923	1397	17	to	to	PART
admet-923	1397	18	forecast	forecast	VERB
admet-923	1397	19	oral	oral	ADJ
admet-923	1397	20	absorption	absorption	NOUN
admet-923	1397	21	of	of	ADP
admet-923	1397	22	dipyridamole	dipyridamole	PROPN
admet-923	1397	23	.	.	PUNCT
admet-923	1398	1	mol	mol	PROPN
admet-923	1398	2	.	.	PUNCT
admet-923	1398	3	pharm	pharm	PROPN
admet-923	1398	4	.	.	PUNCT
admet-923	1399	1	14	14	NUM
admet-923	1399	2	(	(	PUNCT
admet-923	1399	3	2017	2017	NUM
admet-923	1399	4	)	)	PUNCT
admet-923	1399	5	1181–1189	1181–1189	NUM
admet-923	1399	6	.	.	PUNCT
admet-923	1400	1	[	[	X
admet-923	1400	2	142	142	NUM
admet-923	1400	3	]	]	PUNCT
admet-923	1400	4	m.	m.	NOUN
admet-923	1400	5	yamane	yamane	PROPN
admet-923	1400	6	,	,	PUNCT
admet-923	1400	7	k.	k.	PROPN
admet-923	1400	8	matsui	matsui	PROPN
admet-923	1400	9	,	,	PUNCT
admet-923	1400	10	m.	m.	NOUN
admet-923	1400	11	sugihara	sugihara	NOUN
admet-923	1400	12	,	,	PUNCT
admet-923	1400	13	y.	y.	PROPN
admet-923	1400	14	tokunaga	tokunaga	PROPN
admet-923	1400	15	.	.	PUNCT
admet-923	1401	1	the	the	DET
admet-923	1401	2	provisional	provisional	ADJ
admet-923	1401	3	no	no	DET
admet-923	1401	4	-	-	PUNCT
admet-923	1401	5	effect	effect	NOUN
admet-923	1401	6	threshold	threshold	NOUN
admet-923	1401	7	of	of	ADP
admet-923	1401	8	sugar	sugar	NOUN
admet-923	1401	9	alcohols	alcohol	NOUN
admet-923	1401	10	on	on	ADP
admet-923	1401	11	oral	oral	ADJ
admet-923	1401	12	drug	drug	NOUN
admet-923	1401	13	absorption	absorption	NOUN
admet-923	1401	14	estimated	estimate	VERB
admet-923	1401	15	by	by	ADP
admet-923	1401	16	physiologically	physiologically	ADV
admet-923	1401	17	based	base	VERB
admet-923	1401	18	biopharmaceutics	biopharmaceutics	NOUN
admet-923	1401	19	model	model	NOUN
admet-923	1401	20	.	.	PUNCT
admet-923	1402	1	j.	j.	PROPN
admet-923	1402	2	pharm	pharm	PROPN
admet-923	1402	3	.	.	PUNCT
admet-923	1403	1	sci	sci	PROPN
admet-923	1403	2	.	.	PUNCT
admet-923	1403	3	(	(	PUNCT
admet-923	1403	4	2020	2020	NUM
admet-923	1403	5	)	)	PUNCT
admet-923	1403	6	.	.	PUNCT
admet-923	1404	1	[	[	X
admet-923	1404	2	143	143	NUM
admet-923	1404	3	]	]	X
admet-923	1404	4	a.	a.	NOUN
admet-923	1404	5	kambayashi	kambayashi	PROPN
admet-923	1404	6	,	,	PUNCT
admet-923	1404	7	t.	t.	PROPN
admet-923	1404	8	kiyota	kiyota	PROPN
admet-923	1404	9	.	.	PUNCT
admet-923	1405	1	a	a	DET
admet-923	1405	2	physiologically	physiologically	ADV
admet-923	1405	3	-	-	PUNCT
admet-923	1405	4	based	base	VERB
admet-923	1405	5	drug	drug	NOUN
admet-923	1405	6	absorption	absorption	NOUN
admet-923	1405	7	modeling	modeling	NOUN
admet-923	1405	8	for	for	ADP
admet-923	1405	9	orally	orally	ADV
admet-923	1405	10	disintegrating	disintegrate	VERB
admet-923	1405	11	tablets	tablet	NOUN
admet-923	1405	12	.	.	PUNCT
admet-923	1406	1	eur	eur	PROPN
admet-923	1406	2	.	.	PUNCT
admet-923	1407	1	j.	j.	PROPN
admet-923	1407	2	pharm	pharm	PROPN
admet-923	1407	3	.	.	PUNCT
admet-923	1408	1	biopharm	biopharm	PROPN
admet-923	1408	2	.	.	PUNCT
admet-923	1409	1	(	(	PUNCT
admet-923	1409	2	2020	2020	NUM
admet-923	1409	3	)	)	PUNCT
admet-923	1409	4	.	.	PUNCT
admet-923	1410	1	[	[	X
admet-923	1410	2	144	144	NUM
admet-923	1410	3	]	]	X
admet-923	1410	4	y.	y.	PROPN
admet-923	1410	5	cao	cao	PROPN
admet-923	1410	6	,	,	PUNCT
admet-923	1410	7	w.j	w.j	PROPN
admet-923	1410	8	.	.	PROPN
admet-923	1410	9	jusko	jusko	PROPN
admet-923	1410	10	.	.	PUNCT
admet-923	1411	1	applications	application	NOUN
admet-923	1411	2	of	of	ADP
admet-923	1411	3	minimal	minimal	ADJ
admet-923	1411	4	physiologically	physiologically	ADV
admet-923	1411	5	-	-	PUNCT
admet-923	1411	6	based	base	VERB
admet-923	1411	7	pharmacokinetic	pharmacokinetic	ADJ
admet-923	1411	8	models	model	NOUN
admet-923	1411	9	.	.	PUNCT
admet-923	1412	1	j.	j.	PROPN
admet-923	1412	2	pharmacokinet	pharmacokinet	PROPN
admet-923	1412	3	.	.	PUNCT
admet-923	1413	1	pharmacodyn	pharmacodyn	ADV
admet-923	1413	2	.	.	PUNCT
admet-923	1414	1	39	39	NUM
admet-923	1414	2	(	(	PUNCT
admet-923	1414	3	2012	2012	NUM
admet-923	1414	4	)	)	PUNCT
admet-923	1415	1	711–723	711–723	NUM
admet-923	1415	2	.	.	PUNCT
admet-923	1416	1	[	[	X
admet-923	1416	2	145	145	NUM
admet-923	1416	3	]	]	PUNCT
admet-923	1416	4	r.	r.	PROPN
admet-923	1416	5	li	li	PROPN
admet-923	1416	6	,	,	PUNCT
admet-923	1416	7	h.a	h.a	PROPN
admet-923	1416	8	.	.	PROPN
admet-923	1416	9	barton	barton	PROPN
admet-923	1416	10	,	,	PUNCT
admet-923	1416	11	p.d	p.d	PROPN
admet-923	1416	12	.	.	PROPN
admet-923	1416	13	yates	yates	PROPN
admet-923	1416	14	,	,	PUNCT
admet-923	1416	15	a.	a.	PROPN
admet-923	1416	16	ghosh	ghosh	PROPN
admet-923	1416	17	,	,	PUNCT
admet-923	1416	18	a.c	a.c	PROPN
admet-923	1416	19	.	.	PROPN
admet-923	1416	20	wolford	wolford	PROPN
admet-923	1416	21	,	,	PUNCT
admet-923	1416	22	k.a	k.a	PROPN
admet-923	1416	23	.	.	PROPN
admet-923	1416	24	riccardi	riccardi	PROPN
admet-923	1416	25	,	,	PUNCT
admet-923	1416	26	t.s	t.s	PROPN
admet-923	1416	27	.	.	PROPN
admet-923	1416	28	maurer	maurer	PROPN
admet-923	1416	29	.	.	PUNCT
admet-923	1417	1	a	a	DET
admet-923	1417	2	“	"	PUNCT
admet-923	1417	3	middle	middle	ADJ
admet-923	1417	4	-	-	PUNCT
admet-923	1417	5	out	out	NOUN
admet-923	1417	6	”	"	PUNCT
admet-923	1417	7	approach	approach	NOUN
admet-923	1417	8	to	to	ADP
admet-923	1417	9	human	human	ADJ
admet-923	1417	10	pharmacokinetic	pharmacokinetic	ADJ
admet-923	1417	11	predictions	prediction	NOUN
admet-923	1417	12	for	for	ADP
admet-923	1417	13	oatp	oatp	ADJ
admet-923	1417	14	substrates	substrate	NOUN
admet-923	1417	15	using	use	VERB
admet-923	1417	16	physiologically	physiologically	ADV
admet-923	1417	17	-	-	PUNCT
admet-923	1417	18	based	base	VERB
admet-923	1417	19	pharmacokinetic	pharmacokinetic	ADJ
admet-923	1417	20	modeling	modeling	NOUN
admet-923	1417	21	.	.	PUNCT
admet-923	1418	1	j.	j.	PROPN
admet-923	1418	2	pharmacokinet	pharmacokinet	PROPN
admet-923	1418	3	.	.	PUNCT
admet-923	1419	1	pharmacodyn	pharmacodyn	ADV
admet-923	1419	2	.	.	PUNCT
admet-923	1420	1	41	41	NUM
admet-923	1420	2	(	(	PUNCT
admet-923	1420	3	2014	2014	NUM
admet-923	1420	4	)	)	PUNCT
admet-923	1421	1	197–209	197–209	NUM
admet-923	1421	2	.	.	PUNCT
admet-923	1422	1	[	[	X
admet-923	1422	2	146	146	NUM
admet-923	1422	3	]	]	X
admet-923	1422	4	d.-m	d.-m	NOUN
admet-923	1422	5	.	.	PUNCT
admet-923	1423	1	oh	oh	INTJ
admet-923	1423	2	,	,	PUNCT
admet-923	1423	3	r.l	r.l	PROPN
admet-923	1423	4	.	.	PROPN
admet-923	1423	5	curl	curl	PROPN
admet-923	1423	6	,	,	PUNCT
admet-923	1423	7	g.l	g.l	PROPN
admet-923	1423	8	.	.	PROPN
admet-923	1423	9	amidon	amidon	PROPN
admet-923	1423	10	.	.	PUNCT
admet-923	1424	1	estimating	estimate	VERB
admet-923	1424	2	the	the	DET
admet-923	1424	3	fraction	fraction	NOUN
admet-923	1424	4	dose	dose	NOUN
admet-923	1424	5	absorbed	absorb	VERB
admet-923	1424	6	from	from	ADP
admet-923	1424	7	suspensions	suspension	NOUN
admet-923	1424	8	of	of	ADP
admet-923	1424	9	poorly	poorly	ADV
admet-923	1424	10	soluble	soluble	ADJ
admet-923	1424	11	compounds	compound	NOUN
admet-923	1424	12	in	in	ADP
admet-923	1424	13	humans	human	NOUN
admet-923	1424	14	:	:	PUNCT
admet-923	1424	15	a	a	DET
admet-923	1424	16	mathematical	mathematical	ADJ
admet-923	1424	17	model	model	NOUN
admet-923	1424	18	.	.	PUNCT
admet-923	1425	1	pharm	pharm	NOUN
admet-923	1425	2	.	.	PUNCT
admet-923	1426	1	res	re	NOUN
admet-923	1426	2	.	.	PROPN
admet-923	1427	1	10	10	NUM
admet-923	1427	2	(	(	PUNCT
admet-923	1427	3	1993	1993	NUM
admet-923	1427	4	)	)	PUNCT
admet-923	1428	1	264–270	264–270	NUM
admet-923	1428	2	.	.	PUNCT
admet-923	1429	1	[	[	X
admet-923	1429	2	147	147	NUM
admet-923	1429	3	]	]	X
admet-923	1429	4	h.	h.	PROPN
admet-923	1429	5	lennernäs	lennernäs	PROPN
admet-923	1429	6	,	,	PUNCT
admet-923	1429	7	c.g	c.g	PROPN
admet-923	1429	8	.	.	PROPN
admet-923	1429	9	regårdh	regårdh	PROPN
admet-923	1429	10	.	.	PUNCT
admet-923	1430	1	regional	regional	ADJ
admet-923	1430	2	gastrointestinal	gastrointestinal	ADJ
admet-923	1430	3	absorption	absorption	NOUN
admet-923	1430	4	of	of	ADP
admet-923	1430	5	the	the	DET
admet-923	1430	6	beta	beta	NOUN
admet-923	1430	7	-	-	PUNCT
admet-923	1430	8	blocker	blocker	NOUN
admet-923	1430	9	pafenolol	pafenolol	NOUN
admet-923	1430	10	in	in	ADP
admet-923	1430	11	the	the	DET
admet-923	1430	12	rat	rat	NOUN
admet-923	1430	13	and	and	CCONJ
admet-923	1430	14	intestinal	intestinal	ADJ
admet-923	1430	15	transit	transit	NOUN
admet-923	1430	16	rate	rate	NOUN
admet-923	1430	17	determined	determine	VERB
admet-923	1430	18	by	by	ADP
admet-923	1430	19	movement	movement	NOUN
admet-923	1430	20	of	of	ADP
admet-923	1430	21	14c	14c	NOUN
admet-923	1430	22	-	-	PUNCT
admet-923	1430	23	polyethylene	polyethylene	NOUN
admet-923	1430	24	glycol	glycol	NOUN
admet-923	1430	25	(	(	PUNCT
admet-923	1430	26	peg	peg	NOUN
admet-923	1430	27	)	)	PUNCT
admet-923	1430	28	4000	4000	NUM
admet-923	1430	29	.	.	PUNCT
admet-923	1431	1	pharm	pharm	NOUN
admet-923	1431	2	.	.	PUNCT
admet-923	1432	1	res	re	NOUN
admet-923	1432	2	.	.	PUNCT
admet-923	1433	1	an	an	DET
admet-923	1433	2	off	off	NOUN
admet-923	1433	3	.	.	PUNCT
admet-923	1434	1	j.	j.	PROPN
admet-923	1434	2	am	am	PROPN
admet-923	1434	3	.	.	PUNCT
admet-923	1435	1	assoc	assoc	PROPN
admet-923	1435	2	.	.	PUNCT
admet-923	1436	1	pharm	pharm	PROPN
admet-923	1436	2	.	.	PUNCT
admet-923	1437	1	sci	sci	PROPN
admet-923	1437	2	.	.	PROPN
admet-923	1438	1	10	10	NUM
admet-923	1438	2	(	(	PUNCT
admet-923	1438	3	1993	1993	NUM
admet-923	1438	4	)	)	PUNCT
admet-923	1439	1	130–135	130–135	NUM
admet-923	1439	2	.	.	PUNCT
admet-923	1440	1	[	[	X
admet-923	1440	2	148	148	NUM
admet-923	1440	3	]	]	X
admet-923	1440	4	d.	d.	PROPN
admet-923	1440	5	riethorst	riethorst	PROPN
admet-923	1440	6	,	,	PUNCT
admet-923	1440	7	j.	j.	PROPN
admet-923	1440	8	brouwers	brouwers	PROPN
admet-923	1440	9	,	,	PUNCT
admet-923	1440	10	j.	j.	PROPN
admet-923	1440	11	motmans	motmans	PROPN
admet-923	1440	12	,	,	PUNCT
admet-923	1440	13	p.	p.	NOUN
admet-923	1440	14	augustijns	augustijns	NOUN
admet-923	1440	15	.	.	PUNCT
admet-923	1441	1	human	human	ADJ
admet-923	1441	2	intestinal	intestinal	ADJ
admet-923	1441	3	fluid	fluid	NOUN
admet-923	1441	4	factors	factor	NOUN
admet-923	1441	5	affecting	affect	VERB
admet-923	1441	6	intestinal	intestinal	ADJ
admet-923	1441	7	drug	drug	NOUN
admet-923	1441	8	permeation	permeation	NOUN
admet-923	1441	9	in	in	ADP
admet-923	1441	10	vitro	vitro	X
admet-923	1441	11	.	.	PUNCT
admet-923	1442	1	eur	eur	PROPN
admet-923	1442	2	.	.	PUNCT
admet-923	1443	1	j.	j.	PROPN
admet-923	1443	2	pharm	pharm	PROPN
admet-923	1443	3	.	.	PUNCT
admet-923	1444	1	sci	sci	PROPN
admet-923	1444	2	.	.	PROPN
admet-923	1445	1	121	121	NUM
admet-923	1445	2	(	(	PUNCT
admet-923	1445	3	2018	2018	NUM
admet-923	1445	4	)	)	PUNCT
admet-923	1446	1	338–346	338–346	NUM
admet-923	1446	2	.	.	PUNCT
admet-923	1447	1	[	[	X
admet-923	1447	2	149	149	NUM
admet-923	1447	3	]	]	PUNCT
admet-923	1447	4	k.	k.	PROPN
admet-923	1447	5	sugano	sugano	PROPN
admet-923	1447	6	.	.	PUNCT
admet-923	1448	1	calculation	calculation	NOUN
admet-923	1448	2	of	of	ADP
admet-923	1448	3	fraction	fraction	NOUN
admet-923	1448	4	of	of	ADP
admet-923	1448	5	dose	dose	NOUN
admet-923	1448	6	absorbed	absorb	VERB
admet-923	1448	7	:	:	PUNCT
admet-923	1448	8	comparison	comparison	NOUN
admet-923	1448	9	between	between	ADP
admet-923	1448	10	analytical	analytical	ADJ
admet-923	1448	11	solution	solution	NOUN
admet-923	1448	12	based	base	VERB
admet-923	1448	13	on	on	ADP
admet-923	1448	14	one	one	NUM
admet-923	1448	15	compartment	compartment	NOUN
admet-923	1448	16	steady	steady	ADJ
admet-923	1448	17	state	state	NOUN
admet-923	1448	18	concentration	concentration	NOUN
admet-923	1448	19	approximation	approximation	NOUN
admet-923	1448	20	and	and	CCONJ
admet-923	1448	21	dynamic	dynamic	ADJ
admet-923	1448	22	seven	seven	NUM
admet-923	1448	23	compartment	compartment	NOUN
admet-923	1448	24	model	model	NOUN
admet-923	1448	25	.	.	PUNCT
admet-923	1449	1	chem	chem	NOUN
admet-923	1449	2	-	-	PUNCT
admet-923	1449	3	bio	bio	NOUN
admet-923	1449	4	informatics	informatics	PROPN
admet-923	1450	1	j.	j.	PROPN
admet-923	1450	2	9	9	NUM
admet-923	1450	3	(	(	PUNCT
admet-923	1450	4	2009	2009	NUM
admet-923	1450	5	)	)	PUNCT
admet-923	1450	6	75–93	75–93	NUM
admet-923	1450	7	.	.	PUNCT
admet-923	1451	1	[	[	X
admet-923	1451	2	150	150	NUM
admet-923	1451	3	]	]	PUNCT
admet-923	1451	4	m.v.s	m.v.s	NOUN
admet-923	1451	5	.	.	PUNCT
admet-923	1451	6	varma	varma	PROPN
admet-923	1451	7	,	,	PUNCT
admet-923	1451	8	r.s	r.s	PROPN
admet-923	1451	9	.	.	PROPN
admet-923	1451	10	obach	obach	PROPN
admet-923	1451	11	,	,	PUNCT
admet-923	1451	12	c.	c.	PROPN
admet-923	1451	13	rotter	rotter	PROPN
admet-923	1451	14	,	,	PUNCT
admet-923	1451	15	h.r	h.r	PROPN
admet-923	1451	16	.	.	PROPN
admet-923	1451	17	miller	miller	PROPN
admet-923	1451	18	,	,	PUNCT
admet-923	1451	19	g.	g.	PROPN
admet-923	1451	20	chang	chang	PROPN
admet-923	1451	21	,	,	PUNCT
admet-923	1451	22	s.j	s.j	PROPN
admet-923	1451	23	.	.	PROPN
admet-923	1451	24	steyn	steyn	PROPN
admet-923	1451	25	,	,	PUNCT
admet-923	1451	26	a.	a.	PROPN
admet-923	1451	27	el	el	PROPN
admet-923	1451	28	-	-	PROPN
admet-923	1451	29	kattan	kattan	PROPN
admet-923	1451	30	,	,	PUNCT
admet-923	1451	31	m.d	m.d	PROPN
admet-923	1451	32	.	.	PROPN
admet-923	1451	33	troutman	troutman	PROPN
admet-923	1451	34	.	.	PUNCT
admet-923	1452	1	physicochemical	physicochemical	ADJ
admet-923	1452	2	space	space	NOUN
admet-923	1452	3	for	for	ADP
admet-923	1452	4	optimum	optimum	ADJ
admet-923	1452	5	oral	oral	ADJ
admet-923	1452	6	bioavailability	bioavailability	NOUN
admet-923	1452	7	:	:	PUNCT
admet-923	1452	8	contribution	contribution	NOUN
admet-923	1452	9	of	of	ADP
admet-923	1452	10	human	human	ADJ
admet-923	1452	11	intestinal	intestinal	ADJ
admet-923	1452	12	absorption	absorption	NOUN
admet-923	1452	13	and	and	CCONJ
admet-923	1452	14	first	first	ADJ
admet-923	1452	15	-	-	PUNCT
admet-923	1452	16	pass	pass	NOUN
admet-923	1452	17	elimination	elimination	NOUN
admet-923	1452	18	.	.	PUNCT
admet-923	1453	1	j.	j.	PROPN
admet-923	1453	2	med	med	PROPN
admet-923	1453	3	.	.	PROPN
admet-923	1453	4	chem	chem	PROPN
admet-923	1453	5	.	.	PUNCT
admet-923	1454	1	53	53	NUM
admet-923	1454	2	(	(	PUNCT
admet-923	1454	3	2010	2010	NUM
admet-923	1454	4	)	)	PUNCT
admet-923	1454	5	1098–1108	1098–1108	NUM
admet-923	1454	6	.	.	PUNCT
admet-923	1455	1	[	[	X
admet-923	1455	2	151	151	NUM
admet-923	1455	3	]	]	PUNCT
admet-923	1455	4	e.	e.	PROPN
admet-923	1455	5	sjögren	sjögren	PROPN
admet-923	1455	6	,	,	PUNCT
admet-923	1455	7	d.	d.	PROPN
admet-923	1455	8	dahlgren	dahlgren	PROPN
admet-923	1455	9	,	,	PUNCT
admet-923	1455	10	c.	c.	PROPN
admet-923	1455	11	roos	roos	PROPN
admet-923	1455	12	,	,	PUNCT
admet-923	1455	13	h.	h.	PROPN
admet-923	1455	14	lennernäs	lennernäs	PROPN
admet-923	1455	15	.	.	PUNCT
admet-923	1456	1	human	human	ADJ
admet-923	1456	2	in	in	ADP
admet-923	1456	3	vivo	vivo	ADJ
admet-923	1456	4	regional	regional	ADJ
admet-923	1456	5	intestinal	intestinal	ADJ
admet-923	1456	6	permeability	permeability	NOUN
admet-923	1456	7	:	:	PUNCT
admet-923	1456	8	quantitation	quantitation	NOUN
admet-923	1456	9	using	use	VERB
admet-923	1456	10	site	site	NOUN
admet-923	1456	11	-	-	PUNCT
admet-923	1456	12	specific	specific	ADJ
admet-923	1456	13	drug	drug	NOUN
admet-923	1456	14	absorption	absorption	NOUN
admet-923	1456	15	data	datum	NOUN
admet-923	1456	16	.	.	PUNCT
admet-923	1457	1	mol	mol	PROPN
admet-923	1457	2	.	.	PUNCT
admet-923	1457	3	pharm	pharm	PROPN
admet-923	1457	4	.	.	PUNCT
admet-923	1458	1	12	12	NUM
admet-923	1458	2	(	(	PUNCT
admet-923	1458	3	2015	2015	NUM
admet-923	1458	4	)	)	PUNCT
admet-923	1458	5	2026–2039	2026–2039	NUM
admet-923	1458	6	.	.	PUNCT
admet-923	1459	1	[	[	X
admet-923	1459	2	152	152	NUM
admet-923	1459	3	]	]	X
admet-923	1459	4	d.	d.	NOUN
admet-923	1459	5	psachoulias	psachoulias	PROPN
admet-923	1459	6	,	,	PUNCT
admet-923	1459	7	m.	m.	NOUN
admet-923	1459	8	vertzoni	vertzoni	PROPN
admet-923	1459	9	,	,	PUNCT
admet-923	1459	10	k.	k.	PROPN
admet-923	1459	11	goumas	goumas	PROPN
admet-923	1459	12	,	,	PUNCT
admet-923	1459	13	v.	v.	PROPN
admet-923	1459	14	kalioras	kalioras	PROPN
admet-923	1459	15	,	,	PUNCT
admet-923	1459	16	s.	s.	PROPN
admet-923	1459	17	beato	beato	PROPN
admet-923	1459	18	,	,	PUNCT
admet-923	1459	19	j.	j.	PROPN
admet-923	1459	20	butler	butler	PROPN
admet-923	1459	21	,	,	PUNCT
admet-923	1459	22	c.	c.	PROPN
admet-923	1459	23	reppas	reppas	PROPN
admet-923	1459	24	.	.	PUNCT
admet-923	1460	1	precipitation	precipitation	NOUN
admet-923	1460	2	in	in	ADP
admet-923	1460	3	and	and	CCONJ
admet-923	1460	4	supersaturation	supersaturation	NOUN
admet-923	1460	5	of	of	ADP
admet-923	1460	6	contents	content	NOUN
admet-923	1460	7	of	of	ADP
admet-923	1460	8	the	the	DET
admet-923	1460	9	upper	upper	ADJ
admet-923	1460	10	small	small	ADJ
admet-923	1460	11	intestine	intestine	NOUN
admet-923	1460	12	after	after	ADP
admet-923	1460	13	administration	administration	NOUN
admet-923	1460	14	of	of	ADP
admet-923	1460	15	two	two	NUM
admet-923	1460	16	weak	weak	ADJ
admet-923	1460	17	bases	basis	NOUN
admet-923	1460	18	to	to	PART
admet-923	1460	19	fasted	fast	VERB
admet-923	1460	20	adults	adult	NOUN
admet-923	1460	21	.	.	PUNCT
admet-923	1461	1	pharm	pharm	NOUN
admet-923	1461	2	.	.	PUNCT
admet-923	1462	1	res	re	NOUN
admet-923	1462	2	.	.	PUNCT
admet-923	1463	1	28	28	NUM
admet-923	1463	2	(	(	PUNCT
admet-923	1463	3	2011	2011	NUM
admet-923	1463	4	)	)	PUNCT
admet-923	1463	5	3145–3158	3145–3158	NUM
admet-923	1463	6	.	.	PUNCT
admet-923	1464	1	admet	admet	PROPN
admet-923	1464	2	&	&	CCONJ
admet-923	1464	3	dmpk	dmpk	PROPN
admet-923	1464	4	9(2	9(2	NUM
admet-923	1464	5	)	)	PUNCT
admet-923	1464	6	(	(	PUNCT
admet-923	1464	7	2021	2021	NUM
admet-923	1464	8	)	)	PUNCT
admet-923	1464	9	75	75	NUM
admet-923	1464	10	-	-	SYM
admet-923	1464	11	109	109	NUM
admet-923	1464	12	lost	lose	VERB
admet-923	1464	13	in	in	ADP
admet-923	1464	14	modelling	modelling	NOUN
admet-923	1464	15	and	and	CCONJ
admet-923	1464	16	simulation	simulation	NOUN
admet-923	1464	17	?	?	PUNCT
admet-923	1465	1	doi	doi	NOUN
admet-923	1465	2	:	:	PUNCT
admet-923	1465	3	https:/doi.org/10.5599	https:/doi.org/10.5599	PROPN
admet-923	1465	4	/	/	SYM
admet-923	1465	5	admet.923	admet.923	PROPN
admet-923	1465	6	107	107	NUM
admet-923	1466	1	[	[	X
admet-923	1466	2	153	153	NUM
admet-923	1466	3	]	]	PUNCT
admet-923	1466	4	b.	b.	PROPN
admet-923	1466	5	hens	hens	PROPN
admet-923	1466	6	,	,	PUNCT
admet-923	1466	7	j.	j.	PROPN
admet-923	1466	8	brouwers	brouwers	PROPN
admet-923	1466	9	,	,	PUNCT
admet-923	1466	10	m.	m.	NOUN
admet-923	1466	11	corsetti	corsetti	PROPN
admet-923	1466	12	,	,	PUNCT
admet-923	1466	13	p.	p.	NOUN
admet-923	1466	14	augustijns	augustijns	NOUN
admet-923	1466	15	.	.	PUNCT
admet-923	1466	16	supersaturation	supersaturation	NOUN
admet-923	1466	17	and	and	CCONJ
admet-923	1466	18	precipitation	precipitation	NOUN
admet-923	1466	19	of	of	ADP
admet-923	1466	20	posaconazole	posaconazole	NOUN
admet-923	1466	21	upon	upon	SCONJ
admet-923	1466	22	entry	entry	NOUN
admet-923	1466	23	in	in	ADP
admet-923	1466	24	the	the	DET
admet-923	1466	25	upper	upper	ADJ
admet-923	1466	26	small	small	ADJ
admet-923	1466	27	intestine	intestine	NOUN
admet-923	1466	28	in	in	ADP
admet-923	1466	29	humans	human	NOUN
admet-923	1466	30	.	.	PUNCT
admet-923	1467	1	j.	j.	PROPN
admet-923	1467	2	pharm	pharm	PROPN
admet-923	1467	3	.	.	PUNCT
admet-923	1468	1	sci	sci	PROPN
admet-923	1468	2	.	.	PROPN
admet-923	1469	1	105	105	NUM
admet-923	1469	2	(	(	PUNCT
admet-923	1469	3	2016	2016	NUM
admet-923	1469	4	)	)	PUNCT
admet-923	1469	5	2677–2684	2677–2684	NUM
admet-923	1469	6	.	.	PUNCT
admet-923	1470	1	[	[	X
admet-923	1470	2	154	154	NUM
admet-923	1470	3	]	]	X
admet-923	1470	4	k.k.h	k.k.h	PROPN
admet-923	1470	5	.	.	PROPN
admet-923	1470	6	chan	chan	PROPN
admet-923	1470	7	,	,	PUNCT
admet-923	1470	8	f.	f.	PROPN
admet-923	1470	9	langenbucher	langenbucher	PROPN
admet-923	1470	10	,	,	PUNCT
admet-923	1470	11	m.	m.	NOUN
admet-923	1470	12	gibaldi	gibaldi	NOUN
admet-923	1470	13	.	.	PUNCT
admet-923	1471	1	evaluation	evaluation	NOUN
admet-923	1471	2	of	of	ADP
admet-923	1471	3	in	in	ADP
admet-923	1471	4	vivo	vivo	ADJ
admet-923	1471	5	drug	drug	NOUN
admet-923	1471	6	release	release	NOUN
admet-923	1471	7	by	by	ADP
admet-923	1471	8	numerical	numerical	ADJ
admet-923	1471	9	deconvolution	deconvolution	NOUN
admet-923	1471	10	using	use	VERB
admet-923	1471	11	oral	oral	ADJ
admet-923	1471	12	solution	solution	NOUN
admet-923	1471	13	data	datum	NOUN
admet-923	1471	14	as	as	ADP
admet-923	1471	15	weighting	weight	VERB
admet-923	1471	16	function	function	NOUN
admet-923	1471	17	.	.	PUNCT
admet-923	1472	1	j.	j.	PROPN
admet-923	1472	2	pharm	pharm	PROPN
admet-923	1472	3	.	.	PUNCT
admet-923	1473	1	sci	sci	PROPN
admet-923	1473	2	.	.	PROPN
admet-923	1474	1	76	76	NUM
admet-923	1474	2	(	(	PUNCT
admet-923	1474	3	1987	1987	NUM
admet-923	1474	4	)	)	PUNCT
admet-923	1475	1	446–450	446–450	NUM
admet-923	1475	2	.	.	PUNCT
admet-923	1476	1	[	[	X
admet-923	1476	2	155	155	NUM
admet-923	1476	3	]	]	X
admet-923	1476	4	s.	s.	PROPN
admet-923	1476	5	clarysse	clarysse	PROPN
admet-923	1476	6	,	,	PUNCT
admet-923	1476	7	j.	j.	PROPN
admet-923	1476	8	brouwers	brouwers	PROPN
admet-923	1476	9	,	,	PUNCT
admet-923	1476	10	j.	j.	PROPN
admet-923	1476	11	tack	tack	PROPN
admet-923	1476	12	,	,	PUNCT
admet-923	1476	13	p.	p.	PROPN
admet-923	1476	14	annaert	annaert	NOUN
admet-923	1476	15	,	,	PUNCT
admet-923	1476	16	p.	p.	NOUN
admet-923	1476	17	augustijns	augustijns	NOUN
admet-923	1476	18	.	.	PUNCT
admet-923	1477	1	intestinal	intestinal	ADJ
admet-923	1477	2	drug	drug	NOUN
admet-923	1477	3	solubility	solubility	NOUN
admet-923	1477	4	estimation	estimation	NOUN
admet-923	1477	5	based	base	VERB
admet-923	1477	6	on	on	ADP
admet-923	1477	7	simulated	simulated	ADJ
admet-923	1477	8	intestinal	intestinal	ADJ
admet-923	1477	9	fluids	fluid	NOUN
admet-923	1477	10	:	:	PUNCT
admet-923	1477	11	comparison	comparison	NOUN
admet-923	1477	12	with	with	ADP
admet-923	1477	13	solubility	solubility	NOUN
admet-923	1477	14	in	in	ADP
admet-923	1477	15	human	human	ADJ
admet-923	1477	16	intestinal	intestinal	ADJ
admet-923	1477	17	fluids	fluid	NOUN
admet-923	1477	18	.	.	PUNCT
admet-923	1478	1	eur	eur	PROPN
admet-923	1478	2	.	.	PUNCT
admet-923	1479	1	j.	j.	PROPN
admet-923	1479	2	pharm	pharm	PROPN
admet-923	1479	3	.	.	PUNCT
admet-923	1480	1	sci	sci	PROPN
admet-923	1480	2	.	.	PROPN
admet-923	1481	1	43	43	NUM
admet-923	1481	2	(	(	PUNCT
admet-923	1481	3	2011	2011	NUM
admet-923	1481	4	)	)	PUNCT
admet-923	1481	5	260–269	260–269	NUM
admet-923	1481	6	.	.	PUNCT
admet-923	1482	1	[	[	X
admet-923	1482	2	156	156	NUM
admet-923	1482	3	]	]	X
admet-923	1482	4	k.s	k.s	PROPN
admet-923	1482	5	.	.	PROPN
admet-923	1482	6	shingo	shingo	PROPN
admet-923	1482	7	takezawa	takezawa	PROPN
admet-923	1482	8	,	,	PUNCT
admet-923	1482	9	kikuo	kikuo	NOUN
admet-923	1482	10	ozawa	ozawa	PROPN
admet-923	1482	11	,	,	PUNCT
admet-923	1482	12	rishichi	rishichi	NOUN
admet-923	1482	13	mimura	mimura	NOUN
admet-923	1482	14	.	.	PUNCT
admet-923	1483	1	membrane	membrane	NOUN
admet-923	1483	2	permeation	permeation	NOUN
admet-923	1483	3	mechanism	mechanism	NOUN
admet-923	1483	4	of	of	ADP
admet-923	1483	5	solute	solute	NOUN
admet-923	1483	6	in	in	ADP
admet-923	1483	7	dialyzer	dialyzer	NOUN
admet-923	1483	8	.	.	PUNCT
admet-923	1484	1	artif	artif	INTJ
admet-923	1484	2	.	.	PUNCT
admet-923	1485	1	organ	organ	NOUN
admet-923	1485	2	.	.	PUNCT
admet-923	1486	1	13	13	NUM
admet-923	1486	2	(	(	PUNCT
admet-923	1486	3	1984	1984	NUM
admet-923	1486	4	)	)	PUNCT
admet-923	1486	5	1460–1467	1460–1467	NUM
admet-923	1486	6	.	.	PUNCT
admet-923	1487	1	[	[	X
admet-923	1487	2	157	157	NUM
admet-923	1487	3	]	]	PUNCT
admet-923	1487	4	a.	a.	NOUN
admet-923	1487	5	avdeef	avdeef	PROPN
admet-923	1487	6	.	.	PUNCT
admet-923	1488	1	leakiness	leakiness	NOUN
admet-923	1488	2	and	and	CCONJ
admet-923	1488	3	size	size	NOUN
admet-923	1488	4	exclusion	exclusion	NOUN
admet-923	1488	5	of	of	ADP
admet-923	1488	6	paracellular	paracellular	ADJ
admet-923	1488	7	channels	channel	NOUN
admet-923	1488	8	in	in	ADP
admet-923	1488	9	cultured	cultured	ADJ
admet-923	1488	10	epithelial	epithelial	ADJ
admet-923	1488	11	cell	cell	NOUN
admet-923	1488	12	monolayersinterlaboratory	monolayersinterlaboratory	ADJ
admet-923	1488	13	comparison	comparison	NOUN
admet-923	1488	14	.	.	PUNCT
admet-923	1489	1	pharm	pharm	NOUN
admet-923	1489	2	.	.	PUNCT
admet-923	1490	1	res	re	NOUN
admet-923	1490	2	.	.	PROPN
admet-923	1491	1	27	27	NUM
admet-923	1491	2	(	(	PUNCT
admet-923	1491	3	2010	2010	NUM
admet-923	1491	4	)	)	PUNCT
admet-923	1492	1	480–489	480–489	NUM
admet-923	1492	2	.	.	PUNCT
admet-923	1493	1	[	[	X
admet-923	1493	2	158	158	NUM
admet-923	1493	3	]	]	X
admet-923	1493	4	m.	m.	NOUN
admet-923	1493	5	kato	kato	PROPN
admet-923	1493	6	,	,	PUNCT
admet-923	1493	7	k.	k.	PROPN
admet-923	1493	8	chiba	chiba	PROPN
admet-923	1493	9	,	,	PUNCT
admet-923	1493	10	a.	a.	NOUN
admet-923	1493	11	hisaka	hisaka	PROPN
admet-923	1493	12	,	,	PUNCT
admet-923	1493	13	m.	m.	NOUN
admet-923	1493	14	ishigami	ishigami	PROPN
admet-923	1493	15	,	,	PUNCT
admet-923	1493	16	m.	m.	NOUN
admet-923	1493	17	kayama	kayama	PROPN
admet-923	1493	18	,	,	PUNCT
admet-923	1493	19	n.	n.	PROPN
admet-923	1493	20	mizuno	mizuno	PROPN
admet-923	1493	21	,	,	PUNCT
admet-923	1493	22	y.	y.	PROPN
admet-923	1493	23	nagata	nagata	PROPN
admet-923	1493	24	,	,	PUNCT
admet-923	1493	25	s.	s.	PROPN
admet-923	1493	26	takakuwa	takakuwa	PROPN
admet-923	1493	27	,	,	PUNCT
admet-923	1493	28	y.	y.	PROPN
admet-923	1493	29	tsukamoto	tsukamoto	PROPN
admet-923	1493	30	,	,	PUNCT
admet-923	1493	31	k.	k.	PROPN
admet-923	1493	32	ueda	ueda	PROPN
admet-923	1493	33	,	,	PUNCT
admet-923	1493	34	h.	h.	PROPN
admet-923	1493	35	kusuhara	kusuhara	PROPN
admet-923	1493	36	,	,	PUNCT
admet-923	1493	37	k.	k.	PROPN
admet-923	1493	38	ito	ito	PROPN
admet-923	1493	39	,	,	PUNCT
admet-923	1493	40	y.	y.	PROPN
admet-923	1493	41	sugiyama	sugiyama	PROPN
admet-923	1493	42	.	.	PUNCT
admet-923	1494	1	the	the	DET
admet-923	1494	2	intestinal	intestinal	ADJ
admet-923	1494	3	first	first	ADJ
admet-923	1494	4	-	-	PUNCT
admet-923	1494	5	pass	pass	VERB
admet-923	1494	6	metabolism	metabolism	NOUN
admet-923	1494	7	of	of	ADP
admet-923	1494	8	substrates	substrate	NOUN
admet-923	1494	9	of	of	ADP
admet-923	1494	10	cyp3a4	cyp3a4	NOUN
admet-923	1494	11	and	and	CCONJ
admet-923	1494	12	p	p	NOUN
admet-923	1494	13	-	-	PUNCT
admet-923	1494	14	glycoprotei	glycoprotei	NOUN
admet-923	1494	15	—	—	PUNCT
admet-923	1494	16	quantitative	quantitative	ADJ
admet-923	1494	17	analysis	analysis	NOUN
admet-923	1494	18	based	base	VERB
admet-923	1494	19	on	on	ADP
admet-923	1494	20	information	information	NOUN
admet-923	1494	21	from	from	ADP
admet-923	1494	22	the	the	DET
admet-923	1494	23	literature	literature	NOUN
admet-923	1494	24	.	.	PUNCT
admet-923	1495	1	drug	drug	NOUN
admet-923	1495	2	metab	metab	PROPN
admet-923	1495	3	.	.	PUNCT
admet-923	1496	1	pharmacokinet	pharmacokinet	NOUN
admet-923	1496	2	.	.	PUNCT
admet-923	1497	1	18	18	NUM
admet-923	1497	2	(	(	PUNCT
admet-923	1497	3	2004	2004	NUM
admet-923	1497	4	)	)	PUNCT
admet-923	1498	1	365–372	365–372	NUM
admet-923	1498	2	.	.	PUNCT
admet-923	1499	1	[	[	X
admet-923	1499	2	159	159	NUM
admet-923	1499	3	]	]	PUNCT
admet-923	1499	4	h.	h.	PROPN
admet-923	1499	5	lennernäs	lennernäs	PROPN
admet-923	1499	6	.	.	PUNCT
admet-923	1500	1	intestinal	intestinal	ADJ
admet-923	1500	2	permeability	permeability	NOUN
admet-923	1500	3	and	and	CCONJ
admet-923	1500	4	its	its	PRON
admet-923	1500	5	relevance	relevance	NOUN
admet-923	1500	6	for	for	ADP
admet-923	1500	7	absorption	absorption	NOUN
admet-923	1500	8	and	and	CCONJ
admet-923	1500	9	elimination	elimination	NOUN
admet-923	1500	10	,	,	PUNCT
admet-923	1500	11	2007	2007	NUM
admet-923	1500	12	.	.	PUNCT
admet-923	1501	1	[	[	X
admet-923	1501	2	160	160	NUM
admet-923	1501	3	]	]	X
admet-923	1501	4	e.	e.	PROPN
admet-923	1501	5	luzon	luzon	PROPN
admet-923	1501	6	,	,	PUNCT
admet-923	1501	7	k.	k.	PROPN
admet-923	1501	8	blake	blake	PROPN
admet-923	1501	9	,	,	PUNCT
admet-923	1501	10	s.	s.	PROPN
admet-923	1501	11	cole	cole	PROPN
admet-923	1501	12	,	,	PUNCT
admet-923	1501	13	a.	a.	NOUN
admet-923	1501	14	nordmark	nordmark	PROPN
admet-923	1501	15	,	,	PUNCT
admet-923	1501	16	c.	c.	PROPN
admet-923	1501	17	versantvoort	versantvoort	PROPN
admet-923	1501	18	,	,	PUNCT
admet-923	1501	19	e.g.	e.g.	ADV
admet-923	1501	20	berglund	berglund	PROPN
admet-923	1501	21	.	.	PUNCT
admet-923	1502	1	physiologically	physiologically	ADV
admet-923	1502	2	based	base	VERB
admet-923	1502	3	pharmacokinetic	pharmacokinetic	ADJ
admet-923	1502	4	modeling	modeling	NOUN
admet-923	1502	5	in	in	ADP
admet-923	1502	6	regulatory	regulatory	ADJ
admet-923	1502	7	decision	decision	NOUN
admet-923	1502	8	-	-	PUNCT
admet-923	1502	9	making	making	NOUN
admet-923	1502	10	at	at	ADP
admet-923	1502	11	the	the	DET
admet-923	1502	12	european	european	PROPN
admet-923	1502	13	medicines	medicine	NOUN
admet-923	1502	14	agency	agency	NOUN
admet-923	1502	15	.	.	PUNCT
admet-923	1503	1	clin	clin	PROPN
admet-923	1503	2	.	.	PUNCT
admet-923	1504	1	pharmacol	pharmacol	PROPN
admet-923	1504	2	.	.	PUNCT
admet-923	1505	1	ther	ther	PROPN
admet-923	1505	2	.	.	PUNCT
admet-923	1506	1	102	102	NUM
admet-923	1506	2	(	(	PUNCT
admet-923	1506	3	2017	2017	NUM
admet-923	1506	4	)	)	PUNCT
admet-923	1506	5	98–105	98–105	NUM
admet-923	1506	6	.	.	PUNCT
admet-923	1507	1	[	[	X
admet-923	1507	2	161	161	NUM
admet-923	1507	3	]	]	PUNCT
admet-923	1507	4	m.	m.	NOUN
admet-923	1507	5	grimstein	grimstein	NOUN
admet-923	1507	6	,	,	PUNCT
admet-923	1507	7	y.	y.	PROPN
admet-923	1507	8	yang	yang	PROPN
admet-923	1507	9	,	,	PUNCT
admet-923	1507	10	x.	x.	PROPN
admet-923	1507	11	zhang	zhang	PROPN
admet-923	1507	12	,	,	PUNCT
admet-923	1507	13	j.	j.	PROPN
admet-923	1507	14	grillo	grillo	PROPN
admet-923	1507	15	,	,	PUNCT
admet-923	1507	16	s.-m	s.-m	PROPN
admet-923	1507	17	.	.	PUNCT
admet-923	1508	1	huang	huang	PROPN
admet-923	1508	2	,	,	PUNCT
admet-923	1508	3	i.	i.	PROPN
admet-923	1508	4	zineh	zineh	PROPN
admet-923	1508	5	,	,	PUNCT
admet-923	1508	6	y.	y.	PROPN
admet-923	1508	7	wang	wang	PROPN
admet-923	1508	8	.	.	PUNCT
admet-923	1509	1	physiologically	physiologically	ADV
admet-923	1509	2	based	base	VERB
admet-923	1509	3	pharmacokinetic	pharmacokinetic	ADJ
admet-923	1509	4	modeling	modeling	NOUN
admet-923	1509	5	in	in	ADP
admet-923	1509	6	regulatory	regulatory	ADJ
admet-923	1509	7	science	science	NOUN
admet-923	1509	8	:	:	PUNCT
admet-923	1509	9	an	an	DET
admet-923	1509	10	update	update	NOUN
admet-923	1509	11	from	from	ADP
admet-923	1509	12	the	the	DET
admet-923	1509	13	us	us	PROPN
admet-923	1509	14	food	food	NOUN
admet-923	1509	15	and	and	CCONJ
admet-923	1509	16	drug	drug	PROPN
admet-923	1509	17	administration	administration	NOUN
admet-923	1509	18	’s	’s	PART
admet-923	1509	19	office	office	NOUN
admet-923	1509	20	of	of	ADP
admet-923	1509	21	clinical	clinical	ADJ
admet-923	1509	22	pharmacology	pharmacology	NOUN
admet-923	1509	23	.	.	PUNCT
admet-923	1510	1	j.	j.	PROPN
admet-923	1510	2	pharm	pharm	PROPN
admet-923	1510	3	.	.	PUNCT
admet-923	1511	1	sci	sci	PROPN
admet-923	1511	2	.	.	PROPN
admet-923	1512	1	108	108	NUM
admet-923	1512	2	(	(	PUNCT
admet-923	1512	3	2019	2019	NUM
admet-923	1512	4	)	)	PUNCT
admet-923	1512	5	21–25	21–25	NUM
admet-923	1512	6	.	.	PUNCT
admet-923	1513	1	[	[	X
admet-923	1513	2	162	162	NUM
admet-923	1513	3	]	]	PUNCT
admet-923	1513	4	a.	a.	NOUN
admet-923	1513	5	hisaka	hisaka	PROPN
admet-923	1513	6	,	,	PUNCT
admet-923	1513	7	y.	y.	PROPN
admet-923	1513	8	ohno	ohno	PROPN
admet-923	1513	9	,	,	PUNCT
admet-923	1513	10	t.	t.	PROPN
admet-923	1513	11	yamamoto	yamamoto	PROPN
admet-923	1513	12	,	,	PUNCT
admet-923	1513	13	h.	h.	PROPN
admet-923	1513	14	suzuki	suzuki	PROPN
admet-923	1513	15	.	.	PUNCT
admet-923	1514	1	theoretical	theoretical	ADJ
admet-923	1514	2	considerations	consideration	NOUN
admet-923	1514	3	on	on	ADP
admet-923	1514	4	quantitative	quantitative	ADJ
admet-923	1514	5	prediction	prediction	NOUN
admet-923	1514	6	of	of	ADP
admet-923	1514	7	drug	drug	NOUN
admet-923	1514	8	-	-	PUNCT
admet-923	1514	9	drug	drug	NOUN
admet-923	1514	10	interactions	interaction	NOUN
admet-923	1514	11	.	.	PUNCT
admet-923	1515	1	drug	drug	NOUN
admet-923	1515	2	metab	metab	PROPN
admet-923	1515	3	.	.	PUNCT
admet-923	1516	1	pharmacokinet	pharmacokinet	NOUN
admet-923	1516	2	.	.	PUNCT
admet-923	1517	1	25	25	NUM
admet-923	1517	2	(	(	PUNCT
admet-923	1517	3	2010	2010	NUM
admet-923	1517	4	)	)	PUNCT
admet-923	1517	5	48–61	48–61	PROPN
admet-923	1517	6	.	.	PUNCT
admet-923	1518	1	[	[	X
admet-923	1518	2	163	163	NUM
admet-923	1518	3	]	]	X
admet-923	1518	4	y.	y.	PROPN
admet-923	1518	5	ohno	ohno	PROPN
admet-923	1518	6	,	,	PUNCT
admet-923	1518	7	a.	a.	NOUN
admet-923	1518	8	hisaka	hisaka	PROPN
admet-923	1518	9	,	,	PUNCT
admet-923	1518	10	h.	h.	PROPN
admet-923	1518	11	suzuki	suzuki	PROPN
admet-923	1518	12	.	.	PUNCT
admet-923	1519	1	general	general	ADJ
admet-923	1519	2	framework	framework	NOUN
admet-923	1519	3	for	for	ADP
admet-923	1519	4	the	the	DET
admet-923	1519	5	quantitative	quantitative	ADJ
admet-923	1519	6	prediction	prediction	NOUN
admet-923	1519	7	of	of	ADP
admet-923	1519	8	cyp3a4	cyp3a4	NOUN
admet-923	1519	9	-	-	PUNCT
admet-923	1519	10	mediated	mediate	VERB
admet-923	1519	11	oral	oral	ADJ
admet-923	1519	12	drug	drug	NOUN
admet-923	1519	13	interactions	interaction	NOUN
admet-923	1519	14	based	base	VERB
admet-923	1519	15	on	on	ADP
admet-923	1519	16	the	the	DET
admet-923	1519	17	auc	auc	NOUN
admet-923	1519	18	increase	increase	NOUN
admet-923	1519	19	by	by	ADP
admet-923	1519	20	coadministration	coadministration	NOUN
admet-923	1519	21	of	of	ADP
admet-923	1519	22	standard	standard	ADJ
admet-923	1519	23	drugs	drug	NOUN
admet-923	1519	24	.	.	PUNCT
admet-923	1520	1	clin	clin	PROPN
admet-923	1520	2	.	.	PUNCT
admet-923	1520	3	pharmacokinet	pharmacokinet	PROPN
admet-923	1520	4	.	.	PUNCT
admet-923	1521	1	46	46	NUM
admet-923	1521	2	(	(	PUNCT
admet-923	1521	3	2007	2007	NUM
admet-923	1521	4	)	)	PUNCT
admet-923	1522	1	681–696	681–696	NUM
admet-923	1522	2	.	.	PUNCT
admet-923	1523	1	[	[	X
admet-923	1523	2	164	164	NUM
admet-923	1523	3	]	]	PUNCT
admet-923	1523	4	a.	a.	NOUN
admet-923	1523	5	hisaka	hisaka	PROPN
admet-923	1523	6	,	,	PUNCT
admet-923	1523	7	y.	y.	PROPN
admet-923	1523	8	ohno	ohno	PROPN
admet-923	1523	9	,	,	PUNCT
admet-923	1523	10	t.	t.	PROPN
admet-923	1523	11	yamamoto	yamamoto	PROPN
admet-923	1523	12	,	,	PUNCT
admet-923	1523	13	h.	h.	PROPN
admet-923	1523	14	suzuki	suzuki	PROPN
admet-923	1523	15	.	.	PUNCT
admet-923	1523	16	prediction	prediction	NOUN
admet-923	1523	17	of	of	ADP
admet-923	1523	18	pharmacokinetic	pharmacokinetic	ADJ
admet-923	1523	19	drug	drug	NOUN
admet-923	1523	20	-	-	PUNCT
admet-923	1523	21	drug	drug	NOUN
admet-923	1523	22	interaction	interaction	NOUN
admet-923	1523	23	caused	cause	VERB
admet-923	1523	24	by	by	ADP
admet-923	1523	25	changes	change	NOUN
admet-923	1523	26	in	in	ADP
admet-923	1523	27	cytochrome	cytochrome	ADJ
admet-923	1523	28	p450	p450	NUM
admet-923	1523	29	activity	activity	NOUN
admet-923	1523	30	using	use	VERB
admet-923	1523	31	in	in	ADP
admet-923	1523	32	vivo	vivo	ADJ
admet-923	1523	33	information	information	NOUN
admet-923	1523	34	.	.	PUNCT
admet-923	1524	1	pharmacol	pharmacol	PROPN
admet-923	1524	2	.	.	PUNCT
admet-923	1525	1	ther	ther	PROPN
admet-923	1525	2	.	.	PUNCT
admet-923	1526	1	125	125	NUM
admet-923	1526	2	(	(	PUNCT
admet-923	1526	3	2010	2010	NUM
admet-923	1526	4	)	)	PUNCT
admet-923	1526	5	230–248	230–248	NUM
admet-923	1526	6	.	.	PUNCT
admet-923	1527	1	[	[	X
admet-923	1527	2	165	165	NUM
admet-923	1527	3	]	]	PUNCT
admet-923	1527	4	m.	m.	NOUN
admet-923	1527	5	koziolek	koziolek	NOUN
admet-923	1527	6	,	,	PUNCT
admet-923	1527	7	s.	s.	PROPN
admet-923	1527	8	alcaro	alcaro	PROPN
admet-923	1527	9	,	,	PUNCT
admet-923	1527	10	p.	p.	NOUN
admet-923	1527	11	augustijns	augustijns	NOUN
admet-923	1527	12	,	,	PUNCT
admet-923	1527	13	a.w	a.w	PROPN
admet-923	1527	14	.	.	PROPN
admet-923	1527	15	basit	basit	PROPN
admet-923	1527	16	,	,	PUNCT
admet-923	1527	17	m.	m.	NOUN
admet-923	1527	18	grimm	grimm	PROPN
admet-923	1527	19	,	,	PUNCT
admet-923	1527	20	b.	b.	PROPN
admet-923	1527	21	hens	hens	PROPN
admet-923	1527	22	,	,	PUNCT
admet-923	1527	23	c.l	c.l	PROPN
admet-923	1527	24	.	.	PROPN
admet-923	1527	25	hoad	hoad	PROPN
admet-923	1527	26	,	,	PUNCT
admet-923	1527	27	p.	p.	PROPN
admet-923	1527	28	jedamzik	jedamzik	PROPN
admet-923	1527	29	,	,	PUNCT
admet-923	1527	30	c.m	c.m	PROPN
admet-923	1527	31	.	.	PROPN
admet-923	1527	32	madla	madla	PROPN
admet-923	1527	33	,	,	PUNCT
admet-923	1527	34	m.	m.	NOUN
admet-923	1527	35	maliepaard	maliepaard	PROPN
admet-923	1527	36	,	,	PUNCT
admet-923	1527	37	others	other	NOUN
admet-923	1527	38	.	.	PUNCT
admet-923	1528	1	the	the	DET
admet-923	1528	2	mechanisms	mechanism	NOUN
admet-923	1528	3	of	of	ADP
admet-923	1528	4	pharmacokinetic	pharmacokinetic	ADJ
admet-923	1528	5	food	food	NOUN
admet-923	1528	6	-	-	PUNCT
admet-923	1528	7	drug	drug	NOUN
admet-923	1528	8	interactions	interaction	NOUN
admet-923	1528	9	--	--	PUNCT
admet-923	1528	10	a	a	DET
admet-923	1528	11	perspective	perspective	NOUN
admet-923	1528	12	from	from	ADP
admet-923	1528	13	the	the	DET
admet-923	1528	14	ungap	ungap	NOUN
admet-923	1528	15	group	group	NOUN
admet-923	1528	16	.	.	PUNCT
admet-923	1529	1	eur	eur	PROPN
admet-923	1529	2	.	.	PUNCT
admet-923	1530	1	j.	j.	PROPN
admet-923	1530	2	pharm	pharm	PROPN
admet-923	1530	3	.	.	PUNCT
admet-923	1531	1	sci	sci	PROPN
admet-923	1531	2	.	.	PROPN
admet-923	1532	1	134	134	NUM
admet-923	1532	2	(	(	PUNCT
admet-923	1532	3	2019	2019	NUM
admet-923	1532	4	)	)	PUNCT
admet-923	1532	5	31–59	31–59	NUM
admet-923	1532	6	.	.	PUNCT
admet-923	1533	1	[	[	X
admet-923	1533	2	166	166	NUM
admet-923	1533	3	]	]	PUNCT
admet-923	1533	4	p.	p.	NOUN
admet-923	1533	5	macheras	macheras	PROPN
admet-923	1533	6	,	,	PUNCT
admet-923	1533	7	p.	p.	PROPN
admet-923	1533	8	chryssafidis	chryssafidis	PROPN
admet-923	1533	9	.	.	PUNCT
admet-923	1534	1	revising	revise	VERB
admet-923	1534	2	pharmacokinetics	pharmacokinetic	NOUN
admet-923	1534	3	of	of	ADP
admet-923	1534	4	oral	oral	ADJ
admet-923	1534	5	drug	drug	NOUN
admet-923	1534	6	absorption	absorption	NOUN
admet-923	1534	7	:	:	PUNCT
admet-923	1534	8	i	i	PROPN
admet-923	1534	9	models	model	VERB
admet-923	1534	10	based	base	VERB
admet-923	1534	11	on	on	ADP
admet-923	1534	12	biopharmaceutical	biopharmaceutical	ADJ
admet-923	1534	13	/	/	SYM
admet-923	1534	14	physiological	physiological	ADJ
admet-923	1534	15	and	and	CCONJ
admet-923	1534	16	finite	finite	VERB
admet-923	1534	17	absorption	absorption	NOUN
admet-923	1534	18	time	time	NOUN
admet-923	1534	19	concepts	concept	NOUN
admet-923	1534	20	.	.	PUNCT
admet-923	1535	1	pharm	pharm	PROPN
admet-923	1535	2	.	.	PUNCT
admet-923	1536	1	res	re	NOUN
admet-923	1536	2	.	.	PUNCT
admet-923	1537	1	37	37	NUM
admet-923	1537	2	(	(	PUNCT
admet-923	1537	3	2020	2020	NUM
admet-923	1537	4	)	)	PUNCT
admet-923	1537	5	1–13	1–13	NOUN
admet-923	1537	6	.	.	PUNCT
admet-923	1538	1	[	[	X
admet-923	1538	2	167	167	NUM
admet-923	1538	3	]	]	PUNCT
admet-923	1538	4	a.	a.	NOUN
admet-923	1538	5	maharaj	maharaj	PROPN
admet-923	1538	6	,	,	PUNCT
admet-923	1538	7	n.	n.	PROPN
admet-923	1538	8	fotaki	fotaki	PROPN
admet-923	1538	9	,	,	PUNCT
admet-923	1538	10	a.	a.	NOUN
admet-923	1538	11	edginton	edginton	PROPN
admet-923	1538	12	.	.	PUNCT
admet-923	1539	1	parameterization	parameterization	NOUN
admet-923	1539	2	of	of	ADP
admet-923	1539	3	small	small	ADJ
admet-923	1539	4	intestinal	intestinal	ADJ
admet-923	1539	5	water	water	NOUN
admet-923	1539	6	volume	volume	NOUN
admet-923	1539	7	using	use	VERB
admet-923	1539	8	pbpk	pbpk	NOUN
admet-923	1539	9	modeling	modeling	NOUN
admet-923	1539	10	.	.	PUNCT
admet-923	1540	1	eur	eur	PROPN
admet-923	1540	2	.	.	PUNCT
admet-923	1541	1	j.	j.	PROPN
admet-923	1541	2	pharm	pharm	PROPN
admet-923	1541	3	.	.	PUNCT
admet-923	1542	1	sci	sci	PROPN
admet-923	1542	2	.	.	PROPN
admet-923	1543	1	67	67	NUM
admet-923	1543	2	(	(	PUNCT
admet-923	1543	3	2015	2015	NUM
admet-923	1543	4	)	)	PUNCT
admet-923	1544	1	55–64	55–64	NUM
admet-923	1544	2	.	.	PUNCT
admet-923	1545	1	[	[	X
admet-923	1545	2	168	168	NUM
admet-923	1545	3	]	]	PUNCT
admet-923	1545	4	l.	l.	PROPN
admet-923	1545	5	di	di	PROPN
admet-923	1545	6	,	,	PUNCT
admet-923	1545	7	p.	p.	PROPN
admet-923	1545	8	artursson	artursson	PROPN
admet-923	1545	9	,	,	PUNCT
admet-923	1545	10	a.	a.	PROPN
admet-923	1545	11	avdeef	avdeef	PROPN
admet-923	1545	12	,	,	PUNCT
admet-923	1545	13	l.z	l.z	PROPN
admet-923	1545	14	.	.	PROPN
admet-923	1545	15	benet	benet	PROPN
admet-923	1545	16	,	,	PUNCT
admet-923	1545	17	j.b	j.b	PROPN
admet-923	1545	18	.	.	PROPN
admet-923	1545	19	houston	houston	PROPN
admet-923	1545	20	,	,	PUNCT
admet-923	1545	21	m.	m.	PROPN
admet-923	1545	22	kansy	kansy	PROPN
admet-923	1545	23	,	,	PUNCT
admet-923	1545	24	e.h	e.h	PROPN
admet-923	1545	25	.	.	PROPN
admet-923	1545	26	kerns	kerns	PROPN
admet-923	1545	27	,	,	PUNCT
admet-923	1545	28	h.	h.	PROPN
admet-923	1545	29	lennernäs	lennernäs	PROPN
admet-923	1545	30	,	,	PUNCT
admet-923	1545	31	d.a	d.a	PROPN
admet-923	1545	32	.	.	PROPN
admet-923	1545	33	smith	smith	PROPN
admet-923	1545	34	,	,	PUNCT
admet-923	1545	35	k.	k.	PROPN
admet-923	1545	36	sugano	sugano	PROPN
admet-923	1545	37	.	.	PUNCT
admet-923	1546	1	the	the	DET
admet-923	1546	2	critical	critical	ADJ
admet-923	1546	3	role	role	NOUN
admet-923	1546	4	of	of	ADP
admet-923	1546	5	passive	passive	ADJ
admet-923	1546	6	permeability	permeability	NOUN
admet-923	1546	7	in	in	ADP
admet-923	1546	8	designing	design	VERB
admet-923	1546	9	successful	successful	ADJ
admet-923	1546	10	drugs	drug	NOUN
admet-923	1546	11	.	.	PUNCT
admet-923	1547	1	chemmedchem	chemmedchem	PROPN
admet-923	1547	2	.	.	PUNCT
admet-923	1548	1	(	(	PUNCT
admet-923	1548	2	2020	2020	NUM
admet-923	1548	3	)	)	PUNCT
admet-923	1548	4	.	.	PUNCT
admet-923	1549	1	[	[	X
admet-923	1549	2	169	169	NUM
admet-923	1549	3	]	]	PUNCT
admet-923	1549	4	k.	k.	PROPN
admet-923	1549	5	utsey	utsey	PROPN
admet-923	1549	6	,	,	PUNCT
admet-923	1549	7	m.s	m.s	PROPN
admet-923	1549	8	.	.	PROPN
admet-923	1549	9	gastonguay	gastonguay	PROPN
admet-923	1549	10	,	,	PUNCT
admet-923	1549	11	s.	s.	PROPN
admet-923	1549	12	russell	russell	PROPN
admet-923	1549	13	,	,	PUNCT
admet-923	1549	14	r.	r.	PROPN
admet-923	1549	15	freling	freling	PROPN
admet-923	1549	16	,	,	PUNCT
admet-923	1549	17	m.m	m.m	PROPN
admet-923	1549	18	.	.	PROPN
admet-923	1549	19	riggs	riggs	PROPN
admet-923	1549	20	,	,	PUNCT
admet-923	1549	21	a.	a.	PROPN
admet-923	1549	22	elmokadem	elmokadem	PROPN
admet-923	1549	23	.	.	PUNCT
admet-923	1550	1	quantification	quantification	NOUN
admet-923	1550	2	of	of	ADP
admet-923	1550	3	the	the	DET
admet-923	1550	4	impact	impact	NOUN
admet-923	1550	5	of	of	ADP
admet-923	1550	6	partition	partition	NOUN
admet-923	1550	7	coefficient	coefficient	NOUN
admet-923	1550	8	prediction	prediction	NOUN
admet-923	1550	9	methods	method	NOUN
admet-923	1550	10	on	on	ADP
admet-923	1550	11	physiologically	physiologically	ADV
admet-923	1550	12	based	base	VERB
admet-923	1550	13	pharmacokinetic	pharmacokinetic	ADJ
admet-923	1550	14	model	model	NOUN
admet-923	1550	15	output	output	NOUN
admet-923	1550	16	using	use	VERB
admet-923	1550	17	a	a	DET
admet-923	1550	18	standardized	standardized	ADJ
admet-923	1550	19	tissue	tissue	NOUN
admet-923	1550	20	composition	composition	NOUN
admet-923	1550	21	.	.	PUNCT
admet-923	1551	1	drug	drug	NOUN
admet-923	1551	2	metab	metab	NOUN
admet-923	1551	3	.	.	PUNCT
admet-923	1552	1	dispos	dispos	PROPN
admet-923	1552	2	.	.	PUNCT
admet-923	1553	1	48	48	NUM
admet-923	1553	2	(	(	PUNCT
admet-923	1553	3	2020	2020	NUM
admet-923	1553	4	)	)	PUNCT
admet-923	1554	1	903–916	903–916	NUM
admet-923	1554	2	.	.	PUNCT
admet-923	1555	1	[	[	X
admet-923	1555	2	170	170	NUM
admet-923	1555	3	]	]	PUNCT
admet-923	1555	4	k.	k.	PROPN
admet-923	1555	5	valko	valko	PROPN
admet-923	1555	6	,	,	PUNCT
admet-923	1555	7	s.	s.	PROPN
admet-923	1555	8	rava	rava	PROPN
admet-923	1555	9	,	,	PUNCT
admet-923	1555	10	s.	s.	PROPN
admet-923	1555	11	bunally	bunally	ADV
admet-923	1555	12	,	,	PUNCT
admet-923	1555	13	s.	s.	PROPN
admet-923	1555	14	anderson	anderson	PROPN
admet-923	1555	15	.	.	PUNCT
admet-923	1556	1	revisiting	revisit	VERB
admet-923	1556	2	the	the	DET
admet-923	1556	3	application	application	NOUN
admet-923	1556	4	of	of	ADP
admet-923	1556	5	immobilized	immobilized	ADJ
admet-923	1556	6	artificial	artificial	ADJ
admet-923	1556	7	membrane	membrane	NOUN
admet-923	1556	8	(	(	PUNCT
admet-923	1556	9	iam	iam	PROPN
admet-923	1556	10	)	)	PUNCT
admet-923	1556	11	chromatography	chromatography	NOUN
admet-923	1556	12	to	to	PART
admet-923	1556	13	estimate	estimate	VERB
admet-923	1556	14	in	in	ADP
admet-923	1556	15	vivo	vivo	ADJ
admet-923	1556	16	distribution	distribution	NOUN
admet-923	1556	17	properties	property	NOUN
admet-923	1556	18	of	of	ADP
admet-923	1556	19	drug	drug	NOUN
admet-923	1556	20	discovery	discovery	NOUN
admet-923	1556	21	compounds	compound	NOUN
admet-923	1556	22	based	base	VERB
admet-923	1556	23	on	on	ADP
admet-923	1556	24	the	the	DET
admet-923	1556	25	model	model	NOUN
admet-923	1556	26	of	of	ADP
admet-923	1556	27	marketed	market	VERB
admet-923	1556	28	drugs	drug	NOUN
admet-923	1556	29	.	.	PUNCT
admet-923	1557	1	admet	admet	PROPN
admet-923	1557	2	dmpk	dmpk	PROPN
admet-923	1557	3	.	.	PUNCT
admet-923	1558	1	8	8	NUM
admet-923	1558	2	(	(	PUNCT
admet-923	1558	3	2020	2020	NUM
admet-923	1558	4	)	)	PUNCT
admet-923	1559	1	78–97	78–97	NUM
admet-923	1559	2	.	.	PUNCT
admet-923	1560	1	https://doi.org/10.5599/admet.757	https://doi.org/10.5599/admet.757	X
admet-923	1560	2	.	.	PUNCT
admet-923	1561	1	[	[	X
admet-923	1561	2	171	171	NUM
admet-923	1561	3	]	]	X
admet-923	1561	4	f.	f.	PROPN
admet-923	1561	5	lombardo	lombardo	PROPN
admet-923	1561	6	,	,	PUNCT
admet-923	1561	7	j.	j.	PROPN
admet-923	1561	8	bentzien	bentzien	PROPN
admet-923	1561	9	,	,	PUNCT
admet-923	1561	10	g.	g.	PROPN
admet-923	1561	11	berellini	berellini	PROPN
admet-923	1561	12	,	,	PUNCT
admet-923	1561	13	i.	i.	PROPN
admet-923	1561	14	muegge	muegge	PROPN
admet-923	1561	15	.	.	PUNCT
admet-923	1562	1	in	in	ADP
admet-923	1562	2	silico	silico	NOUN
admet-923	1562	3	models	model	NOUN
admet-923	1562	4	of	of	ADP
admet-923	1562	5	human	human	ADJ
admet-923	1562	6	pk	pk	NOUN
admet-923	1562	7	parameters	parameter	NOUN
admet-923	1562	8	.	.	PUNCT
admet-923	1563	1	prediction	prediction	NOUN
admet-923	1563	2	of	of	ADP
admet-923	1563	3	volume	volume	NOUN
admet-923	1563	4	of	of	ADP
admet-923	1563	5	distribution	distribution	NOUN
admet-923	1563	6	using	use	VERB
admet-923	1563	7	an	an	DET
admet-923	1563	8	extensive	extensive	ADJ
admet-923	1563	9	data	datum	NOUN
admet-923	1563	10	set	set	VERB
admet-923	1563	11	and	and	CCONJ
admet-923	1563	12	a	a	DET
admet-923	1563	13	reduced	reduced	ADJ
admet-923	1563	14	number	number	NOUN
admet-923	1563	15	of	of	ADP
admet-923	1563	16	parameters	parameter	NOUN
admet-923	1563	17	.	.	PUNCT
admet-923	1564	1	j.	j.	PROPN
admet-923	1564	2	pharm	pharm	PROPN
admet-923	1564	3	.	.	PUNCT
admet-923	1565	1	sci	sci	PROPN
admet-923	1565	2	.	.	PUNCT
admet-923	1565	3	(	(	PUNCT
admet-923	1565	4	2020	2020	NUM
admet-923	1565	5	)	)	PUNCT
admet-923	1565	6	.	.	PUNCT
admet-923	1566	1	https://doi.org/10.5599/admet.923	https://doi.org/10.5599/admet.923	X
admet-923	1566	2	kiyohiko	kiyohiko	PROPN
admet-923	1566	3	sugano	sugano	PROPN
admet-923	1566	4	admet	admet	PROPN
admet-923	1566	5	&	&	CCONJ
admet-923	1566	6	dmpk	dmpk	PROPN
admet-923	1566	7	9(2	9(2	NUM
admet-923	1566	8	)	)	PUNCT
admet-923	1566	9	(	(	PUNCT
admet-923	1566	10	2021	2021	NUM
admet-923	1566	11	)	)	PUNCT
admet-923	1566	12	75	75	NUM
admet-923	1566	13	-	-	SYM
admet-923	1566	14	109	109	NUM
admet-923	1566	15	108	108	NUM
admet-923	1566	16	[	[	X
admet-923	1566	17	172	172	NUM
admet-923	1566	18	]	]	X
admet-923	1566	19	d.	d.	PROPN
admet-923	1566	20	hallifax	hallifax	PROPN
admet-923	1566	21	,	,	PUNCT
admet-923	1566	22	f.l	f.l	PROPN
admet-923	1566	23	.	.	PROPN
admet-923	1566	24	wood	wood	NOUN
admet-923	1566	25	.	.	PUNCT
admet-923	1567	1	importance	importance	NOUN
admet-923	1567	2	of	of	ADP
admet-923	1567	3	the	the	DET
admet-923	1567	4	unstirred	unstirred	ADJ
admet-923	1567	5	water	water	NOUN
admet-923	1567	6	layer	layer	NOUN
admet-923	1567	7	and	and	CCONJ
admet-923	1567	8	hepatocyte	hepatocyte	NOUN
admet-923	1567	9	membrane	membrane	NOUN
admet-923	1567	10	integrity	integrity	NOUN
admet-923	1567	11	in	in	ADP
admet-923	1567	12	vitro	vitro	X
admet-923	1567	13	for	for	ADP
admet-923	1567	14	quantification	quantification	NOUN
admet-923	1567	15	of	of	ADP
admet-923	1567	16	intrinsic	intrinsic	ADJ
admet-923	1567	17	metabolic	metabolic	NOUN
admet-923	1567	18	clearance	clearance	NOUN
admet-923	1567	19	.	.	PUNCT
admet-923	1568	1	drug	drug	NOUN
admet-923	1568	2	metab	metab	NOUN
admet-923	1568	3	.	.	PUNCT
admet-923	1569	1	dispos	dispos	PROPN
admet-923	1569	2	.	.	PUNCT
admet-923	1570	1	46	46	NUM
admet-923	1570	2	(	(	PUNCT
admet-923	1570	3	2018	2018	NUM
admet-923	1570	4	)	)	PUNCT
admet-923	1570	5	268–278	268–278	NUM
admet-923	1570	6	.	.	PUNCT
admet-923	1571	1	[	[	X
admet-923	1571	2	173	173	NUM
admet-923	1571	3	]	]	X
admet-923	1571	4	k.	k.	PROPN
admet-923	1571	5	sugano	sugano	PROPN
admet-923	1571	6	.	.	PUNCT
admet-923	1572	1	aqueous	aqueous	ADJ
admet-923	1572	2	boundary	boundary	ADJ
admet-923	1572	3	layers	layer	NOUN
admet-923	1572	4	related	relate	VERB
admet-923	1572	5	to	to	ADP
admet-923	1572	6	oral	oral	ADJ
admet-923	1572	7	absorption	absorption	NOUN
admet-923	1572	8	of	of	ADP
admet-923	1572	9	a	a	DET
admet-923	1572	10	drug	drug	NOUN
admet-923	1572	11	:	:	PUNCT
admet-923	1572	12	from	from	ADP
admet-923	1572	13	dissolution	dissolution	NOUN
admet-923	1572	14	of	of	ADP
admet-923	1572	15	a	a	DET
admet-923	1572	16	drug	drug	NOUN
admet-923	1572	17	to	to	ADP
admet-923	1572	18	carrier	carrier	NOUN
admet-923	1572	19	mediated	mediate	VERB
admet-923	1572	20	transport	transport	NOUN
admet-923	1572	21	and	and	CCONJ
admet-923	1572	22	intestinal	intestinal	ADJ
admet-923	1572	23	wall	wall	NOUN
admet-923	1572	24	metabolism	metabolism	NOUN
admet-923	1572	25	.	.	PUNCT
admet-923	1573	1	mol	mol	PROPN
admet-923	1573	2	.	.	PUNCT
admet-923	1573	3	pharm	pharm	PROPN
admet-923	1573	4	.	.	PUNCT
admet-923	1574	1	7	7	NUM
admet-923	1574	2	(	(	PUNCT
admet-923	1574	3	2010	2010	NUM
admet-923	1574	4	)	)	PUNCT
admet-923	1574	5	1362–1373	1362–1373	NUM
admet-923	1574	6	.	.	PUNCT
admet-923	1575	1	[	[	X
admet-923	1575	2	174	174	NUM
admet-923	1575	3	]	]	PUNCT
admet-923	1575	4	l.	l.	PROPN
admet-923	1575	5	di	di	PROPN
admet-923	1575	6	,	,	PUNCT
admet-923	1575	7	e.h	e.h	PROPN
admet-923	1575	8	.	.	PROPN
admet-923	1575	9	kerns	kerns	PROPN
admet-923	1575	10	,	,	PUNCT
admet-923	1575	11	k.	k.	PROPN
admet-923	1575	12	fan	fan	PROPN
admet-923	1575	13	,	,	PUNCT
admet-923	1575	14	o.j	o.j	PROPN
admet-923	1575	15	.	.	PROPN
admet-923	1575	16	mcconnell	mcconnell	PROPN
admet-923	1575	17	,	,	PUNCT
admet-923	1575	18	g.t	g.t	PROPN
admet-923	1575	19	.	.	PROPN
admet-923	1575	20	carter	carter	PROPN
admet-923	1575	21	.	.	PUNCT
admet-923	1576	1	high	high	ADJ
admet-923	1576	2	throughput	throughput	PROPN
admet-923	1576	3	artificial	artificial	ADJ
admet-923	1576	4	membrane	membrane	NOUN
admet-923	1576	5	permeability	permeability	NOUN
admet-923	1576	6	assay	assay	VERB
admet-923	1576	7	for	for	ADP
admet-923	1576	8	blood	blood	NOUN
admet-923	1576	9	--	--	PUNCT
admet-923	1576	10	brain	brain	NOUN
admet-923	1576	11	barrier	barrier	NOUN
admet-923	1576	12	.	.	PUNCT
admet-923	1577	1	eur	eur	PROPN
admet-923	1577	2	.	.	PUNCT
admet-923	1578	1	j.	j.	PROPN
admet-923	1578	2	med	med	PROPN
admet-923	1578	3	.	.	PROPN
admet-923	1578	4	chem	chem	PROPN
admet-923	1578	5	.	.	PUNCT
admet-923	1579	1	38	38	NUM
admet-923	1579	2	(	(	PUNCT
admet-923	1579	3	2003	2003	NUM
admet-923	1579	4	)	)	PUNCT
admet-923	1580	1	223–232	223–232	NUM
admet-923	1580	2	.	.	PUNCT
admet-923	1581	1	[	[	X
admet-923	1581	2	175	175	NUM
admet-923	1581	3	]	]	X
admet-923	1581	4	c.	c.	PROPN
admet-923	1581	5	dagenais	dagenais	PROPN
admet-923	1581	6	,	,	PUNCT
admet-923	1581	7	a.	a.	NOUN
admet-923	1581	8	avdeef	avdeef	PROPN
admet-923	1581	9	,	,	PUNCT
admet-923	1581	10	o.	o.	PROPN
admet-923	1581	11	tsinman	tsinman	NOUN
admet-923	1581	12	,	,	PUNCT
admet-923	1581	13	a.	a.	PROPN
admet-923	1581	14	dudley	dudley	PROPN
admet-923	1581	15	,	,	PUNCT
admet-923	1581	16	r.	r.	PROPN
admet-923	1581	17	beliveau	beliveau	PROPN
admet-923	1581	18	.	.	PUNCT
admet-923	1582	1	p	p	X
admet-923	1582	2	-	-	PUNCT
admet-923	1582	3	glycoprotein	glycoprotein	ADJ
admet-923	1582	4	deficient	deficient	ADJ
admet-923	1582	5	mouse	mouse	NOUN
admet-923	1582	6	in	in	ADP
admet-923	1582	7	situ	situ	ADJ
admet-923	1582	8	blood	blood	NOUN
admet-923	1582	9	-	-	PUNCT
admet-923	1582	10	brain	brain	NOUN
admet-923	1582	11	barrier	barrier	NOUN
admet-923	1582	12	permeability	permeability	NOUN
admet-923	1582	13	and	and	CCONJ
admet-923	1582	14	its	its	PRON
admet-923	1582	15	prediction	prediction	NOUN
admet-923	1582	16	using	use	VERB
admet-923	1582	17	an	an	PRON
admet-923	1582	18	in	in	ADP
admet-923	1582	19	combo	combo	PROPN
admet-923	1582	20	pampa	pampa	PROPN
admet-923	1582	21	model	model	PROPN
admet-923	1582	22	.	.	PUNCT
admet-923	1583	1	eur	eur	PROPN
admet-923	1583	2	.	.	PUNCT
admet-923	1584	1	j.	j.	PROPN
admet-923	1584	2	pharm	pharm	PROPN
admet-923	1584	3	.	.	PUNCT
admet-923	1585	1	sci	sci	PROPN
admet-923	1585	2	.	.	PROPN
admet-923	1586	1	38	38	NUM
admet-923	1586	2	(	(	PUNCT
admet-923	1586	3	2009	2009	NUM
admet-923	1586	4	)	)	PUNCT
admet-923	1586	5	121–137	121–137	NUM
admet-923	1586	6	.	.	PUNCT
admet-923	1587	1	[	[	X
admet-923	1587	2	176	176	X
admet-923	1587	3	]	]	X
admet-923	1587	4	b.	b.	PROPN
admet-923	1587	5	sinkó	sinkó	PROPN
admet-923	1587	6	,	,	PUNCT
admet-923	1587	7	t.m	t.m	PROPN
admet-923	1587	8	.	.	PROPN
admet-923	1587	9	garrigues	garrigues	PROPN
admet-923	1587	10	,	,	PUNCT
admet-923	1587	11	g.t	g.t	PROPN
admet-923	1587	12	.	.	PROPN
admet-923	1587	13	balogh	balogh	PROPN
admet-923	1587	14	,	,	PUNCT
admet-923	1587	15	z.k	z.k	PROPN
admet-923	1587	16	.	.	PROPN
admet-923	1587	17	nagy	nagy	PROPN
admet-923	1587	18	,	,	PUNCT
admet-923	1587	19	o.	o.	PROPN
admet-923	1587	20	tsinman	tsinman	NOUN
admet-923	1587	21	,	,	PUNCT
admet-923	1587	22	a.	a.	PROPN
admet-923	1587	23	avdeef	avdeef	PROPN
admet-923	1587	24	,	,	PUNCT
admet-923	1587	25	k.	k.	PROPN
admet-923	1587	26	takács	takács	PROPN
admet-923	1587	27	-	-	PUNCT
admet-923	1587	28	novák	novák	PROPN
admet-923	1587	29	.	.	PROPN
admet-923	1587	30	skinpampa	skinpampa	PROPN
admet-923	1587	31	:	:	PUNCT
admet-923	1587	32	a	a	DET
admet-923	1587	33	new	new	ADJ
admet-923	1587	34	method	method	NOUN
admet-923	1587	35	for	for	ADP
admet-923	1587	36	fast	fast	ADJ
admet-923	1587	37	prediction	prediction	NOUN
admet-923	1587	38	of	of	ADP
admet-923	1587	39	skin	skin	NOUN
admet-923	1587	40	penetration	penetration	NOUN
admet-923	1587	41	.	.	PUNCT
admet-923	1588	1	eur	eur	PROPN
admet-923	1588	2	.	.	PUNCT
admet-923	1589	1	j.	j.	PROPN
admet-923	1589	2	pharm	pharm	PROPN
admet-923	1589	3	.	.	PUNCT
admet-923	1590	1	sci	sci	PROPN
admet-923	1590	2	.	.	PROPN
admet-923	1591	1	45	45	NUM
admet-923	1591	2	(	(	PUNCT
admet-923	1591	3	2012	2012	NUM
admet-923	1591	4	)	)	PUNCT
admet-923	1592	1	698–707	698–707	NUM
admet-923	1592	2	.	.	PUNCT
admet-923	1593	1	[	[	X
admet-923	1593	2	177	177	NUM
admet-923	1593	3	]	]	PUNCT
admet-923	1593	4	a.	a.	NOUN
admet-923	1593	5	avdeef	avdeef	PROPN
admet-923	1593	6	.	.	PUNCT
admet-923	1594	1	absorption	absorption	NOUN
admet-923	1594	2	and	and	CCONJ
admet-923	1594	3	drug	drug	NOUN
admet-923	1594	4	development	development	NOUN
admet-923	1594	5	:	:	PUNCT
admet-923	1594	6	solubility	solubility	NOUN
admet-923	1594	7	,	,	PUNCT
admet-923	1594	8	permeability	permeability	NOUN
admet-923	1594	9	,	,	PUNCT
admet-923	1594	10	and	and	CCONJ
admet-923	1594	11	charge	charge	NOUN
admet-923	1594	12	state	state	NOUN
admet-923	1594	13	,	,	PUNCT
admet-923	1594	14	second	second	ADJ
admet-923	1594	15	edition	edition	NOUN
admet-923	1594	16	,	,	PUNCT
admet-923	1594	17	john	john	PROPN
admet-923	1594	18	wiley	wiley	PROPN
admet-923	1594	19	&	&	CCONJ
admet-923	1594	20	sons	sons	PROPN
admet-923	1594	21	,	,	PUNCT
admet-923	1594	22	inc	inc	PROPN
admet-923	1594	23	.	.	PROPN
admet-923	1594	24	,	,	PUNCT
admet-923	1594	25	2012	2012	NUM
admet-923	1594	26	.	.	PUNCT
admet-923	1595	1	[	[	X
admet-923	1595	2	178	178	NUM
admet-923	1595	3	]	]	PUNCT
admet-923	1595	4	k.	k.	PROPN
admet-923	1595	5	sugano	sugano	PROPN
admet-923	1595	6	.	.	PUNCT
admet-923	1596	1	a	a	DET
admet-923	1596	2	simulation	simulation	NOUN
admet-923	1596	3	of	of	ADP
admet-923	1596	4	oral	oral	ADJ
admet-923	1596	5	absorption	absorption	NOUN
admet-923	1596	6	using	use	VERB
admet-923	1596	7	classical	classical	ADJ
admet-923	1596	8	nucleation	nucleation	NOUN
admet-923	1596	9	theory	theory	NOUN
admet-923	1596	10	.	.	PUNCT
admet-923	1597	1	int	int	NOUN
admet-923	1597	2	.	.	PUNCT
admet-923	1598	1	j.	j.	PROPN
admet-923	1598	2	pharm	pharm	PROPN
admet-923	1598	3	.	.	PUNCT
admet-923	1599	1	378	378	NUM
admet-923	1599	2	(	(	PUNCT
admet-923	1599	3	2009	2009	NUM
admet-923	1599	4	)	)	PUNCT
admet-923	1599	5	.	.	PUNCT
admet-923	1600	1	[	[	X
admet-923	1600	2	179	179	NUM
admet-923	1600	3	]	]	X
admet-923	1600	4	m.	m.	NOUN
admet-923	1600	5	higuchi	higuchi	PROPN
admet-923	1600	6	,	,	PUNCT
admet-923	1600	7	y.	y.	PROPN
admet-923	1600	8	yoshihashi	yoshihashi	PROPN
admet-923	1600	9	,	,	PUNCT
admet-923	1600	10	k.	k.	PROPN
admet-923	1600	11	tarada	tarada	PROPN
admet-923	1600	12	,	,	PUNCT
admet-923	1600	13	k.	k.	PROPN
admet-923	1600	14	sugano	sugano	PROPN
admet-923	1600	15	.	.	PUNCT
admet-923	1601	1	minimum	minimum	ADJ
admet-923	1601	2	rotation	rotation	NOUN
admet-923	1601	3	speed	speed	NOUN
admet-923	1601	4	to	to	PART
admet-923	1601	5	prevent	prevent	VERB
admet-923	1601	6	coning	cone	VERB
admet-923	1601	7	phenomena	phenomenon	NOUN
admet-923	1601	8	in	in	ADP
admet-923	1601	9	compendium	compendium	NOUN
admet-923	1601	10	paddle	paddle	NOUN
admet-923	1601	11	dissolution	dissolution	NOUN
admet-923	1601	12	apparatus	apparatus	NOUN
admet-923	1601	13	.	.	PUNCT
admet-923	1602	1	eur	eur	PROPN
admet-923	1602	2	.	.	PUNCT
admet-923	1603	1	j.	j.	PROPN
admet-923	1603	2	pharm	pharm	PROPN
admet-923	1603	3	.	.	PUNCT
admet-923	1604	1	sci	sci	PROPN
admet-923	1604	2	.	.	PROPN
admet-923	1605	1	65	65	NUM
admet-923	1605	2	(	(	PUNCT
admet-923	1605	3	2014	2014	NUM
admet-923	1605	4	)	)	PUNCT
admet-923	1605	5	74–78	74–78	PROPN
admet-923	1605	6	.	.	PUNCT
admet-923	1606	1	[	[	X
admet-923	1606	2	180	180	NUM
admet-923	1606	3	]	]	PUNCT
admet-923	1606	4	c.	c.	PROPN
admet-923	1606	5	stillhart	stillhart	PROPN
admet-923	1606	6	,	,	PUNCT
admet-923	1606	7	k.	k.	PROPN
admet-923	1606	8	vučićević	vučićević	PROPN
admet-923	1606	9	,	,	PUNCT
admet-923	1606	10	p.	p.	NOUN
admet-923	1606	11	augustijns	augustijns	NOUN
admet-923	1606	12	,	,	PUNCT
admet-923	1606	13	a.w	a.w	PROPN
admet-923	1606	14	.	.	PROPN
admet-923	1606	15	basit	basit	PROPN
admet-923	1606	16	,	,	PUNCT
admet-923	1606	17	h.	h.	PROPN
admet-923	1606	18	batchelor	batchelor	PROPN
admet-923	1606	19	,	,	PUNCT
admet-923	1606	20	t.r	t.r	PROPN
admet-923	1606	21	.	.	PROPN
admet-923	1606	22	flanagan	flanagan	PROPN
admet-923	1606	23	,	,	PUNCT
admet-923	1606	24	i.	i.	PROPN
admet-923	1606	25	gesquiere	gesquiere	PROPN
admet-923	1606	26	,	,	PUNCT
admet-923	1606	27	r.	r.	PROPN
admet-923	1606	28	greupink	greupink	PROPN
admet-923	1606	29	,	,	PUNCT
admet-923	1606	30	d.	d.	PROPN
admet-923	1606	31	keszthelyi	keszthelyi	PROPN
admet-923	1606	32	,	,	PUNCT
admet-923	1606	33	m.	m.	PROPN
admet-923	1606	34	koskinen	koskinen	PROPN
admet-923	1606	35	,	,	PUNCT
admet-923	1606	36	others	other	NOUN
admet-923	1606	37	.	.	PUNCT
admet-923	1607	1	impact	impact	NOUN
admet-923	1607	2	of	of	ADP
admet-923	1607	3	gastrointestinal	gastrointestinal	ADJ
admet-923	1607	4	physiology	physiology	NOUN
admet-923	1607	5	on	on	ADP
admet-923	1607	6	drug	drug	NOUN
admet-923	1607	7	absorption	absorption	NOUN
admet-923	1607	8	in	in	ADP
admet-923	1607	9	special	special	ADJ
admet-923	1607	10	populations	population	NOUN
admet-923	1607	11	--	--	PUNCT
admet-923	1607	12	an	an	DET
admet-923	1607	13	ungap	ungap	NOUN
admet-923	1607	14	review	review	NOUN
admet-923	1607	15	.	.	PUNCT
admet-923	1608	1	eur	eur	PROPN
admet-923	1608	2	.	.	PUNCT
admet-923	1609	1	j.	j.	PROPN
admet-923	1609	2	pharm	pharm	PROPN
admet-923	1609	3	.	.	PUNCT
admet-923	1610	1	sci	sci	PROPN
admet-923	1610	2	.	.	PUNCT
admet-923	1610	3	(	(	PUNCT
admet-923	1610	4	2020	2020	NUM
admet-923	1610	5	)	)	PUNCT
admet-923	1610	6	105280	105280	NUM
admet-923	1610	7	.	.	PUNCT
admet-923	1611	1	[	[	X
admet-923	1611	2	181	181	NUM
admet-923	1611	3	]	]	X
admet-923	1611	4	m.	m.	NOUN
admet-923	1611	5	vertzoni	vertzoni	PROPN
admet-923	1611	6	,	,	PUNCT
admet-923	1611	7	p.	p.	NOUN
admet-923	1611	8	augustijns	augustijns	NOUN
admet-923	1611	9	,	,	PUNCT
admet-923	1611	10	m.	m.	NOUN
admet-923	1611	11	grimm	grimm	NOUN
admet-923	1611	12	,	,	PUNCT
admet-923	1611	13	m.	m.	NOUN
admet-923	1611	14	koziolek	koziolek	NOUN
admet-923	1611	15	,	,	PUNCT
admet-923	1611	16	g.	g.	PROPN
admet-923	1611	17	lemmens	lemmens	PROPN
admet-923	1611	18	,	,	PUNCT
admet-923	1611	19	n.	n.	PROPN
admet-923	1611	20	parrott	parrott	PROPN
admet-923	1611	21	,	,	PUNCT
admet-923	1611	22	c.	c.	PROPN
admet-923	1611	23	pentafragka	pentafragka	PROPN
admet-923	1611	24	,	,	PUNCT
admet-923	1611	25	c.	c.	PROPN
admet-923	1611	26	reppas	reppas	PROPN
admet-923	1611	27	,	,	PUNCT
admet-923	1611	28	j.	j.	PROPN
admet-923	1611	29	rubbens	rubbens	PROPN
admet-923	1611	30	,	,	PUNCT
admet-923	1611	31	j.	j.	PROPN
admet-923	1611	32	van	van	PROPN
admet-923	1611	33	den	den	PROPN
admet-923	1611	34	abeele	abeele	PROPN
admet-923	1611	35	,	,	PUNCT
admet-923	1611	36	others	other	NOUN
admet-923	1611	37	.	.	PUNCT
admet-923	1612	1	impact	impact	NOUN
admet-923	1612	2	of	of	ADP
admet-923	1612	3	regional	regional	ADJ
admet-923	1612	4	differences	difference	NOUN
admet-923	1612	5	along	along	ADP
admet-923	1612	6	the	the	DET
admet-923	1612	7	gastrointestinal	gastrointestinal	ADJ
admet-923	1612	8	tract	tract	NOUN
admet-923	1612	9	of	of	ADP
admet-923	1612	10	healthy	healthy	ADJ
admet-923	1612	11	adults	adult	NOUN
admet-923	1612	12	on	on	ADP
admet-923	1612	13	oral	oral	ADJ
admet-923	1612	14	drug	drug	NOUN
admet-923	1612	15	absorption	absorption	NOUN
admet-923	1612	16	:	:	PUNCT
admet-923	1612	17	an	an	DET
admet-923	1612	18	ungap	ungap	NOUN
admet-923	1612	19	review	review	NOUN
admet-923	1612	20	.	.	PUNCT
admet-923	1613	1	eur	eur	PROPN
admet-923	1613	2	.	.	PUNCT
admet-923	1614	1	j.	j.	PROPN
admet-923	1614	2	pharm	pharm	PROPN
admet-923	1614	3	.	.	PUNCT
admet-923	1615	1	sci	sci	PROPN
admet-923	1615	2	.	.	PROPN
admet-923	1616	1	134	134	NUM
admet-923	1616	2	(	(	PUNCT
admet-923	1616	3	2019	2019	NUM
admet-923	1616	4	)	)	PUNCT
admet-923	1616	5	153–175	153–175	NUM
admet-923	1616	6	.	.	PUNCT
admet-923	1617	1	[	[	X
admet-923	1617	2	182	182	NUM
admet-923	1617	3	]	]	X
admet-923	1617	4	d.m	d.m	PROPN
admet-923	1617	5	.	.	PROPN
admet-923	1617	6	mudie	mudie	PROPN
admet-923	1617	7	,	,	PUNCT
admet-923	1617	8	g.l	g.l	PROPN
admet-923	1617	9	.	.	PROPN
admet-923	1617	10	amidon	amidon	PROPN
admet-923	1617	11	,	,	PUNCT
admet-923	1617	12	g.e	g.e	PROPN
admet-923	1617	13	.	.	PROPN
admet-923	1617	14	amidon	amidon	PROPN
admet-923	1617	15	.	.	PUNCT
admet-923	1618	1	physiological	physiological	ADJ
admet-923	1618	2	parameters	parameter	NOUN
admet-923	1618	3	for	for	ADP
admet-923	1618	4	oral	oral	ADJ
admet-923	1618	5	delivery	delivery	NOUN
admet-923	1618	6	and	and	CCONJ
admet-923	1618	7	in	in	ADP
admet-923	1618	8	vitro	vitro	X
admet-923	1618	9	testing	testing	NOUN
admet-923	1618	10	.	.	PUNCT
admet-923	1619	1	mol	mol	PROPN
admet-923	1619	2	.	.	PUNCT
admet-923	1619	3	pharm	pharm	PROPN
admet-923	1619	4	.	.	PUNCT
admet-923	1620	1	7	7	NUM
admet-923	1620	2	(	(	PUNCT
admet-923	1620	3	2010	2010	NUM
admet-923	1620	4	)	)	PUNCT
admet-923	1620	5	1388–1405	1388–1405	NUM
admet-923	1620	6	.	.	PUNCT
admet-923	1621	1	[	[	X
admet-923	1621	2	183	183	NUM
admet-923	1621	3	]	]	X
admet-923	1621	4	b.	b.	PROPN
admet-923	1621	5	hens	hens	PROPN
admet-923	1621	6	,	,	PUNCT
admet-923	1621	7	y.	y.	PROPN
admet-923	1621	8	tsume	tsume	PROPN
admet-923	1621	9	,	,	PUNCT
admet-923	1621	10	m.	m.	NOUN
admet-923	1621	11	bermejo	bermejo	NOUN
admet-923	1621	12	,	,	PUNCT
admet-923	1621	13	p.	p.	NOUN
admet-923	1621	14	paixao	paixao	PROPN
admet-923	1621	15	,	,	PUNCT
admet-923	1621	16	m.j	m.j	PROPN
admet-923	1621	17	.	.	PROPN
admet-923	1621	18	koenigsknecht	koenigsknecht	PROPN
admet-923	1621	19	,	,	PUNCT
admet-923	1621	20	j.r	j.r	PROPN
admet-923	1621	21	.	.	PROPN
admet-923	1621	22	baker	baker	PROPN
admet-923	1621	23	,	,	PUNCT
admet-923	1621	24	w.l	w.l	PROPN
admet-923	1621	25	.	.	PROPN
admet-923	1621	26	hasler	hasler	PROPN
admet-923	1621	27	,	,	PUNCT
admet-923	1621	28	r.	r.	PROPN
admet-923	1621	29	lionberger	lionberger	PROPN
admet-923	1621	30	,	,	PUNCT
admet-923	1621	31	j.	j.	PROPN
admet-923	1621	32	fan	fan	PROPN
admet-923	1621	33	,	,	PUNCT
admet-923	1621	34	j.	j.	PROPN
admet-923	1621	35	dickens	dickens	PROPN
admet-923	1621	36	,	,	PUNCT
admet-923	1621	37	k.	k.	PROPN
admet-923	1621	38	shedden	shedden	PROPN
admet-923	1621	39	,	,	PUNCT
admet-923	1621	40	b.	b.	PROPN
admet-923	1621	41	wen	wen	PROPN
admet-923	1621	42	,	,	PUNCT
admet-923	1621	43	j.	j.	PROPN
admet-923	1621	44	wysocki	wysocki	PROPN
admet-923	1621	45	,	,	PUNCT
admet-923	1621	46	r.	r.	PROPN
admet-923	1621	47	loebenberg	loebenberg	PROPN
admet-923	1621	48	,	,	PUNCT
admet-923	1621	49	a.	a.	PROPN
admet-923	1621	50	lee	lee	PROPN
admet-923	1621	51	,	,	PUNCT
admet-923	1621	52	a.	a.	PROPN
admet-923	1621	53	frances	frances	PROPN
admet-923	1621	54	,	,	PUNCT
admet-923	1621	55	g.	g.	PROPN
admet-923	1621	56	amidon	amidon	PROPN
admet-923	1621	57	,	,	PUNCT
admet-923	1621	58	a.	a.	PROPN
admet-923	1621	59	yu	yu	PROPN
admet-923	1621	60	,	,	PUNCT
admet-923	1621	61	g.	g.	PROPN
admet-923	1621	62	benninghoff	benninghoff	PROPN
admet-923	1621	63	,	,	PUNCT
admet-923	1621	64	n.	n.	PROPN
admet-923	1621	65	salehi	salehi	PROPN
admet-923	1621	66	,	,	PUNCT
admet-923	1621	67	a.	a.	PROPN
admet-923	1621	68	talattof	talattof	PROPN
admet-923	1621	69	,	,	PUNCT
admet-923	1621	70	d.	d.	PROPN
admet-923	1621	71	sun	sun	PROPN
admet-923	1621	72	,	,	PUNCT
admet-923	1621	73	g.l	g.l	PROPN
admet-923	1621	74	.	.	PROPN
admet-923	1621	75	amidon	amidon	PROPN
admet-923	1621	76	.	.	PUNCT
admet-923	1622	1	low	low	ADJ
admet-923	1622	2	buffer	buffer	NOUN
admet-923	1622	3	capacity	capacity	NOUN
admet-923	1622	4	and	and	CCONJ
admet-923	1622	5	alternating	alternate	VERB
admet-923	1622	6	motility	motility	NOUN
admet-923	1622	7	along	along	ADP
admet-923	1622	8	the	the	DET
admet-923	1622	9	human	human	ADJ
admet-923	1622	10	gastrointestinal	gastrointestinal	ADJ
admet-923	1622	11	tract	tract	NOUN
admet-923	1622	12	:	:	PUNCT
admet-923	1622	13	implications	implication	NOUN
admet-923	1622	14	for	for	ADP
admet-923	1622	15	in	in	ADP
admet-923	1622	16	vivo	vivo	ADJ
admet-923	1622	17	dissolution	dissolution	NOUN
admet-923	1622	18	and	and	CCONJ
admet-923	1622	19	absorption	absorption	NOUN
admet-923	1622	20	of	of	ADP
admet-923	1622	21	ionizable	ionizable	ADJ
admet-923	1622	22	drugs	drug	NOUN
admet-923	1622	23	.	.	PUNCT
admet-923	1623	1	mol	mol	PROPN
admet-923	1623	2	.	.	PUNCT
admet-923	1623	3	pharm	pharm	PROPN
admet-923	1623	4	.	.	PUNCT
admet-923	1624	1	14	14	NUM
admet-923	1624	2	(	(	PUNCT
admet-923	1624	3	2017	2017	NUM
admet-923	1624	4	)	)	PUNCT
admet-923	1624	5	4281–4294	4281–4294	NOUN
admet-923	1624	6	.	.	PUNCT
admet-923	1625	1	[	[	X
admet-923	1625	2	184	184	NUM
admet-923	1625	3	]	]	PUNCT
admet-923	1625	4	j.	j.	PROPN
admet-923	1625	5	al	al	PROPN
admet-923	1625	6	-	-	PUNCT
admet-923	1625	7	gousous	gousous	ADJ
admet-923	1625	8	,	,	PUNCT
admet-923	1625	9	g.l	g.l	PROPN
admet-923	1625	10	.	.	PROPN
admet-923	1625	11	amidon	amidon	PROPN
admet-923	1625	12	,	,	PUNCT
admet-923	1625	13	p.	p.	PROPN
admet-923	1625	14	langguth	langguth	NOUN
admet-923	1625	15	.	.	PUNCT
admet-923	1626	1	toward	toward	ADP
admet-923	1626	2	biopredictive	biopredictive	ADJ
admet-923	1626	3	dissolution	dissolution	NOUN
admet-923	1626	4	for	for	ADP
admet-923	1626	5	enteric	enteric	ADJ
admet-923	1626	6	coated	coat	VERB
admet-923	1626	7	dosage	dosage	NOUN
admet-923	1626	8	forms	form	NOUN
admet-923	1626	9	.	.	PUNCT
admet-923	1627	1	mol	mol	PROPN
admet-923	1627	2	.	.	PUNCT
admet-923	1627	3	pharm	pharm	PROPN
admet-923	1627	4	.	.	PUNCT
admet-923	1628	1	13	13	NUM
admet-923	1628	2	(	(	PUNCT
admet-923	1628	3	2016	2016	NUM
admet-923	1628	4	)	)	PUNCT
admet-923	1628	5	1927–1936	1927–1936	NUM
admet-923	1628	6	.	.	PUNCT
admet-923	1629	1	[	[	X
admet-923	1629	2	185	185	NUM
admet-923	1629	3	]	]	PUNCT
admet-923	1629	4	j.	j.	PROPN
admet-923	1629	5	al	al	PROPN
admet-923	1629	6	-	-	PUNCT
admet-923	1629	7	gousous	gousous	ADJ
admet-923	1629	8	,	,	PUNCT
admet-923	1629	9	k.x	k.x	PROPN
admet-923	1629	10	.	.	PROPN
admet-923	1629	11	sun	sun	PROPN
admet-923	1629	12	,	,	PUNCT
admet-923	1629	13	d.p	d.p	PROPN
admet-923	1629	14	.	.	PROPN
admet-923	1629	15	mcnamara	mcnamara	PROPN
admet-923	1629	16	,	,	PUNCT
admet-923	1629	17	b.	b.	PROPN
admet-923	1629	18	hens	hens	PROPN
admet-923	1629	19	,	,	PUNCT
admet-923	1629	20	n.	n.	NOUN
admet-923	1629	21	salehi	salehi	PROPN
admet-923	1629	22	,	,	PUNCT
admet-923	1629	23	p.	p.	PROPN
admet-923	1629	24	langguth	langguth	NOUN
admet-923	1629	25	,	,	PUNCT
admet-923	1629	26	m.	m.	NOUN
admet-923	1629	27	bermejo	bermejo	PROPN
admet-923	1629	28	,	,	PUNCT
admet-923	1629	29	g.e	g.e	PROPN
admet-923	1629	30	.	.	PROPN
admet-923	1629	31	amidon	amidon	PROPN
admet-923	1629	32	,	,	PUNCT
admet-923	1629	33	g.l	g.l	PROPN
admet-923	1629	34	.	.	PROPN
admet-923	1629	35	amidon	amidon	PROPN
admet-923	1629	36	.	.	PUNCT
admet-923	1630	1	mass	mass	PROPN
admet-923	1630	2	transport	transport	NOUN
admet-923	1630	3	analysis	analysis	NOUN
admet-923	1630	4	of	of	ADP
admet-923	1630	5	the	the	DET
admet-923	1630	6	enhanced	enhance	VERB
admet-923	1630	7	buffer	buffer	NOUN
admet-923	1630	8	capacity	capacity	NOUN
admet-923	1630	9	of	of	ADP
admet-923	1630	10	the	the	DET
admet-923	1630	11	bicarbonate	bicarbonate	NOUN
admet-923	1630	12	-	-	PUNCT
admet-923	1630	13	co2	co2	NOUN
admet-923	1630	14	buffer	buffer	NOUN
admet-923	1630	15	in	in	ADP
admet-923	1630	16	a	a	DET
admet-923	1630	17	phase	phase	NOUN
admet-923	1630	18	-	-	PUNCT
admet-923	1630	19	heterogenous	heterogenous	ADJ
admet-923	1630	20	system	system	NOUN
admet-923	1630	21	:	:	PUNCT
admet-923	1630	22	physiological	physiological	ADJ
admet-923	1630	23	and	and	CCONJ
admet-923	1630	24	pharmaceutical	pharmaceutical	NOUN
admet-923	1630	25	significance	significance	NOUN
admet-923	1630	26	.	.	PUNCT
admet-923	1631	1	mol	mol	X
admet-923	1631	2	.	.	PUNCT
admet-923	1631	3	pharm	pharm	PROPN
admet-923	1631	4	.	.	PUNCT
admet-923	1632	1	15	15	NUM
admet-923	1632	2	(	(	PUNCT
admet-923	1632	3	2018	2018	NUM
admet-923	1632	4	)	)	PUNCT
admet-923	1632	5	5291–5301	5291–5301	NUM
admet-923	1632	6	.	.	PUNCT
admet-923	1633	1	[	[	X
admet-923	1633	2	186	186	NUM
admet-923	1633	3	]	]	PUNCT
admet-923	1633	4	t.	t.	NOUN
admet-923	1633	5	uekusa	uekusa	PROPN
admet-923	1633	6	,	,	PUNCT
admet-923	1633	7	j.	j.	PROPN
admet-923	1633	8	oki	oki	PROPN
admet-923	1633	9	,	,	PUNCT
admet-923	1633	10	m.	m.	NOUN
admet-923	1633	11	omori	omori	PROPN
admet-923	1633	12	,	,	PUNCT
admet-923	1633	13	d.	d.	PROPN
admet-923	1633	14	watanabe	watanabe	PROPN
admet-923	1633	15	,	,	PUNCT
admet-923	1633	16	d.	d.	PROPN
admet-923	1633	17	inoue	inoue	PROPN
admet-923	1633	18	,	,	PUNCT
admet-923	1633	19	k.	k.	PROPN
admet-923	1633	20	sugano	sugano	PROPN
admet-923	1633	21	.	.	PUNCT
admet-923	1634	1	effect	effect	NOUN
admet-923	1634	2	of	of	ADP
admet-923	1634	3	buffer	buffer	NOUN
admet-923	1634	4	capacity	capacity	NOUN
admet-923	1634	5	on	on	ADP
admet-923	1634	6	dissolution	dissolution	NOUN
admet-923	1634	7	and	and	CCONJ
admet-923	1634	8	supersaturation	supersaturation	NOUN
admet-923	1634	9	profiles	profile	NOUN
admet-923	1634	10	of	of	ADP
admet-923	1634	11	pioglitazone	pioglitazone	NOUN
admet-923	1634	12	hydrochloride	hydrochloride	NOUN
admet-923	1634	13	.	.	PUNCT
admet-923	1635	1	j.	j.	PROPN
admet-923	1635	2	drug	drug	PROPN
admet-923	1635	3	deliv	deliv	PROPN
admet-923	1635	4	.	.	PUNCT
admet-923	1636	1	sci	sci	PROPN
admet-923	1636	2	.	.	PROPN
admet-923	1636	3	technol	technol	PROPN
admet-923	1636	4	.	.	PUNCT
admet-923	1637	1	55	55	NUM
admet-923	1637	2	(	(	PUNCT
admet-923	1637	3	2020	2020	NUM
admet-923	1637	4	)	)	PUNCT
admet-923	1637	5	101492	101492	NUM
admet-923	1637	6	.	.	PUNCT
admet-923	1638	1	[	[	X
admet-923	1638	2	187	187	NUM
admet-923	1638	3	]	]	PUNCT
admet-923	1638	4	h.	h.	PROPN
admet-923	1638	5	ogata	ogata	PROPN
admet-923	1638	6	,	,	PUNCT
admet-923	1638	7	n.	n.	PROPN
admet-923	1638	8	aoyagi	aoyagi	PROPN
admet-923	1638	9	,	,	PUNCT
admet-923	1638	10	n.	n.	PROPN
admet-923	1638	11	kaniwa	kaniwa	PROPN
admet-923	1638	12	,	,	PUNCT
admet-923	1638	13	a.	a.	NOUN
admet-923	1638	14	ejima	ejima	PROPN
admet-923	1638	15	,	,	PUNCT
admet-923	1638	16	t.	t.	PROPN
admet-923	1638	17	kitaura	kitaura	PROPN
admet-923	1638	18	,	,	PUNCT
admet-923	1638	19	t.	t.	PROPN
admet-923	1638	20	ohki	ohki	PROPN
admet-923	1638	21	,	,	PUNCT
admet-923	1638	22	k.	k.	PROPN
admet-923	1638	23	kitamura	kitamura	PROPN
admet-923	1638	24	.	.	PUNCT
admet-923	1639	1	evaluation	evaluation	NOUN
admet-923	1639	2	of	of	ADP
admet-923	1639	3	beagle	beagle	NOUN
admet-923	1639	4	dogs	dog	NOUN
admet-923	1639	5	as	as	ADP
admet-923	1639	6	an	an	DET
admet-923	1639	7	animal	animal	NOUN
admet-923	1639	8	model	model	NOUN
admet-923	1639	9	for	for	ADP
admet-923	1639	10	bioavailability	bioavailability	NOUN
admet-923	1639	11	testing	testing	NOUN
admet-923	1639	12	of	of	ADP
admet-923	1639	13	cinnarizine	cinnarizine	NOUN
admet-923	1639	14	capsules	capsule	NOUN
admet-923	1639	15	.	.	PUNCT
admet-923	1640	1	int	int	NOUN
admet-923	1640	2	.	.	PUNCT
admet-923	1641	1	j.	j.	PROPN
admet-923	1641	2	pharm	pharm	PROPN
admet-923	1641	3	.	.	PUNCT
admet-923	1642	1	29	29	NUM
admet-923	1642	2	(	(	PUNCT
admet-923	1642	3	1986	1986	NUM
admet-923	1642	4	)	)	PUNCT
admet-923	1643	1	121–126	121–126	NUM
admet-923	1643	2	.	.	PUNCT
admet-923	1644	1	[	[	X
admet-923	1644	2	188	188	NUM
admet-923	1644	3	]	]	PUNCT
admet-923	1644	4	k.	k.	PROPN
admet-923	1644	5	sagawa	sagawa	PROPN
admet-923	1644	6	,	,	PUNCT
admet-923	1644	7	f.	f.	PROPN
admet-923	1644	8	li	li	PROPN
admet-923	1644	9	,	,	PUNCT
admet-923	1644	10	r.	r.	PROPN
admet-923	1644	11	liese	liese	PROPN
admet-923	1644	12	,	,	PUNCT
admet-923	1644	13	s.c	s.c	PROPN
admet-923	1644	14	.	.	PROPN
admet-923	1644	15	sutton	sutton	PROPN
admet-923	1644	16	.	.	PUNCT
admet-923	1645	1	fed	fed	PROPN
admet-923	1645	2	and	and	CCONJ
admet-923	1645	3	fasted	fast	VERB
admet-923	1645	4	gastric	gastric	ADJ
admet-923	1645	5	ph	ph	ADJ
admet-923	1645	6	and	and	CCONJ
admet-923	1645	7	gastric	gastric	ADJ
admet-923	1645	8	residence	residence	NOUN
admet-923	1645	9	time	time	NOUN
admet-923	1645	10	in	in	ADP
admet-923	1645	11	conscious	conscious	ADJ
admet-923	1645	12	beagle	beagle	NOUN
admet-923	1645	13	dogs	dog	NOUN
admet-923	1645	14	.	.	PUNCT
admet-923	1646	1	j.	j.	PROPN
admet-923	1646	2	pharm	pharm	PROPN
admet-923	1646	3	.	.	PUNCT
admet-923	1647	1	sci	sci	PROPN
admet-923	1647	2	.	.	PROPN
admet-923	1648	1	98	98	NUM
admet-923	1648	2	(	(	PUNCT
admet-923	1648	3	2009	2009	NUM
admet-923	1648	4	)	)	PUNCT
admet-923	1648	5	2494–2500	2494–2500	NUM
admet-923	1648	6	.	.	PUNCT
admet-923	1649	1	[	[	X
admet-923	1649	2	189	189	NUM
admet-923	1649	3	]	]	X
admet-923	1649	4	c.y	c.y	PROPN
admet-923	1649	5	.	.	PROPN
admet-923	1649	6	lui	lui	PROPN
admet-923	1649	7	,	,	PUNCT
admet-923	1649	8	g.l	g.l	PROPN
admet-923	1649	9	.	.	PROPN
admet-923	1649	10	amidon	amidon	PROPN
admet-923	1649	11	,	,	PUNCT
admet-923	1649	12	r.r	r.r	PROPN
admet-923	1649	13	.	.	PROPN
admet-923	1649	14	berardi	berardi	PROPN
admet-923	1649	15	,	,	PUNCT
admet-923	1649	16	d.	d.	PROPN
admet-923	1649	17	fleisher	fleisher	PROPN
admet-923	1649	18	,	,	PUNCT
admet-923	1649	19	c.	c.	PROPN
admet-923	1649	20	youngberg	youngberg	PROPN
admet-923	1649	21	,	,	PUNCT
admet-923	1649	22	j.b	j.b	PROPN
admet-923	1649	23	.	.	PROPN
admet-923	1649	24	dressman	dressman	PROPN
admet-923	1649	25	.	.	PUNCT
admet-923	1650	1	comparison	comparison	NOUN
admet-923	1650	2	of	of	ADP
admet-923	1650	3	gastrointestinal	gastrointestinal	ADJ
admet-923	1650	4	ph	ph	NOUN
admet-923	1650	5	in	in	ADP
admet-923	1650	6	dogs	dog	NOUN
admet-923	1650	7	and	and	CCONJ
admet-923	1650	8	humans	human	NOUN
admet-923	1650	9	:	:	PUNCT
admet-923	1650	10	implications	implication	NOUN
admet-923	1650	11	on	on	ADP
admet-923	1650	12	the	the	DET
admet-923	1650	13	use	use	NOUN
admet-923	1650	14	of	of	ADP
admet-923	1650	15	the	the	DET
admet-923	1650	16	beagle	beagle	NOUN
admet-923	1650	17	dog	dog	NOUN
admet-923	1650	18	as	as	ADP
admet-923	1650	19	a	a	DET
admet-923	1650	20	model	model	NOUN
admet-923	1650	21	for	for	ADP
admet-923	1650	22	oral	oral	ADJ
admet-923	1650	23	absorption	absorption	NOUN
admet-923	1650	24	in	in	ADP
admet-923	1650	25	humans	human	NOUN
admet-923	1650	26	[	[	X
admet-923	1650	27	published	publish	VERB
admet-923	1650	28	erratum	erratum	PROPN
admet-923	1650	29	appears	appear	VERB
admet-923	1650	30	in	in	ADP
admet-923	1650	31	j	j	PROPN
admet-923	1650	32	pharm	pharm	PROPN
admet-923	1650	33	sci	sci	PROPN
admet-923	1650	34	1986	1986	NUM
admet-923	1650	35	dec;75(12):1207	dec;75(12):1207	NOUN
admet-923	1650	36	]	]	PUNCT
admet-923	1650	37	.	.	PUNCT
admet-923	1651	1	j.	j.	PROPN
admet-923	1651	2	pharm	pharm	PROPN
admet-923	1651	3	.	.	PUNCT
admet-923	1652	1	sci	sci	PROPN
admet-923	1652	2	.	.	PROPN
admet-923	1653	1	75	75	NUM
admet-923	1653	2	(	(	PUNCT
admet-923	1653	3	1986	1986	NUM
admet-923	1653	4	)	)	PUNCT
admet-923	1654	1	271–274	271–274	NUM
admet-923	1654	2	.	.	PUNCT
admet-923	1655	1	[	[	X
admet-923	1655	2	190	190	NUM
admet-923	1655	3	]	]	PUNCT
admet-923	1655	4	n.	n.	NOUN
admet-923	1655	5	matsumura	matsumura	ADV
admet-923	1655	6	,	,	PUNCT
admet-923	1655	7	y.	y.	PROPN
admet-923	1655	8	yamaura	yamaura	PROPN
admet-923	1655	9	,	,	PUNCT
admet-923	1655	10	j.	j.	PROPN
admet-923	1655	11	katagi	katagi	PROPN
admet-923	1655	12	,	,	PUNCT
admet-923	1655	13	s.	s.	PROPN
admet-923	1655	14	ono	ono	PROPN
admet-923	1655	15	,	,	PUNCT
admet-923	1655	16	s.	s.	PROPN
admet-923	1655	17	kim	kim	PROPN
admet-923	1655	18	,	,	PUNCT
admet-923	1655	19	s.	s.	PROPN
admet-923	1655	20	yamashita	yamashita	PROPN
admet-923	1655	21	,	,	PUNCT
admet-923	1655	22	k.	k.	PROPN
admet-923	1655	23	sugano	sugano	PROPN
admet-923	1655	24	.	.	PUNCT
admet-923	1656	1	evaluation	evaluation	NOUN
admet-923	1656	2	of	of	ADP
admet-923	1656	3	using	use	VERB
admet-923	1656	4	dogs	dog	NOUN
admet-923	1656	5	to	to	PART
admet-923	1656	6	predict	predict	VERB
admet-923	1656	7	fraction	fraction	NOUN
admet-923	1656	8	of	of	ADP
admet-923	1656	9	oral	oral	ADJ
admet-923	1656	10	dose	dose	NOUN
admet-923	1656	11	absorbed	absorb	VERB
admet-923	1656	12	in	in	ADP
admet-923	1656	13	humans	human	NOUN
admet-923	1656	14	for	for	ADP
admet-923	1656	15	poorly	poorly	ADV
admet-923	1656	16	water	water	NOUN
admet-923	1656	17	-	-	PUNCT
admet-923	1656	18	soluble	soluble	ADJ
admet-923	1656	19	drugs	drug	NOUN
admet-923	1656	20	.	.	PUNCT
admet-923	1657	1	j.	j.	PROPN
admet-923	1657	2	pharm	pharm	PROPN
admet-923	1657	3	.	.	PUNCT
admet-923	1658	1	sci	sci	PROPN
admet-923	1658	2	.	.	PROPN
admet-923	1659	1	107	107	NUM
admet-923	1659	2	(	(	PUNCT
admet-923	1659	3	2018	2018	NUM
admet-923	1659	4	)	)	PUNCT
admet-923	1659	5	2489–2496	2489–2496	NUM
admet-923	1659	6	.	.	PUNCT
admet-923	1660	1	admet	admet	PROPN
admet-923	1660	2	&	&	CCONJ
admet-923	1660	3	dmpk	dmpk	PROPN
admet-923	1660	4	9(2	9(2	NUM
admet-923	1660	5	)	)	PUNCT
admet-923	1660	6	(	(	PUNCT
admet-923	1660	7	2021	2021	NUM
admet-923	1660	8	)	)	PUNCT
admet-923	1660	9	75	75	NUM
admet-923	1660	10	-	-	SYM
admet-923	1660	11	109	109	NUM
admet-923	1660	12	lost	lose	VERB
admet-923	1660	13	in	in	ADP
admet-923	1660	14	modelling	modelling	NOUN
admet-923	1660	15	and	and	CCONJ
admet-923	1660	16	simulation	simulation	NOUN
admet-923	1660	17	?	?	PUNCT
admet-923	1661	1	doi	doi	NOUN
admet-923	1661	2	:	:	PUNCT
admet-923	1661	3	https:/doi.org/10.5599	https:/doi.org/10.5599	PROPN
admet-923	1661	4	/	/	SYM
admet-923	1661	5	admet.923	admet.923	NUM
admet-923	1661	6	109	109	NUM
admet-923	1661	7	[	[	SYM
admet-923	1661	8	191	191	NUM
admet-923	1661	9	]	]	PUNCT
admet-923	1661	10	r.	r.	PROPN
admet-923	1661	11	solid	solid	PROPN
admet-923	1661	12	,	,	PUNCT
admet-923	1661	13	o.	o.	ADJ
admet-923	1661	14	dosage	dosage	NOUN
admet-923	1661	15	.	.	PUNCT
admet-923	1662	1	guidance	guidance	NOUN
admet-923	1662	2	for	for	ADP
admet-923	1662	3	industry	industry	NOUN
admet-923	1662	4	guidance	guidance	NOUN
admet-923	1662	5	for	for	ADP
admet-923	1662	6	industry	industry	NOUN
admet-923	1662	7	dissolution	dissolution	NOUN
admet-923	1662	8	testing	testing	NOUN
admet-923	1662	9	of	of	ADP
admet-923	1662	10	immediate	immediate	ADJ
admet-923	1662	11	.	.	PUNCT
admet-923	1663	1	(	(	PUNCT
admet-923	1663	2	1997	1997	NUM
admet-923	1663	3	)	)	PUNCT
admet-923	1663	4	.	.	PUNCT
admet-923	1664	1	[	[	X
admet-923	1664	2	192	192	NUM
admet-923	1664	3	]	]	X
admet-923	1664	4	v.p	v.p	PROPN
admet-923	1664	5	.	.	PROPN
admet-923	1664	6	shah	shah	PROPN
admet-923	1664	7	,	,	PUNCT
admet-923	1664	8	l.j	l.j	PROPN
admet-923	1664	9	.	.	PROPN
admet-923	1664	10	lesko	lesko	PROPN
admet-923	1664	11	,	,	PUNCT
admet-923	1664	12	j.	j.	PROPN
admet-923	1664	13	fan	fan	PROPN
admet-923	1664	14	,	,	PUNCT
admet-923	1664	15	n.	n.	PROPN
admet-923	1664	16	fleischer	fleischer	PROPN
admet-923	1664	17	,	,	PUNCT
admet-923	1664	18	j.	j.	PROPN
admet-923	1664	19	handerson	handerson	PROPN
admet-923	1664	20	,	,	PUNCT
admet-923	1664	21	h.	h.	PROPN
admet-923	1664	22	malinowski	malinowski	PROPN
admet-923	1664	23	,	,	PUNCT
admet-923	1664	24	m.	m.	NOUN
admet-923	1664	25	makary	makary	NOUN
admet-923	1664	26	,	,	PUNCT
admet-923	1664	27	l.	l.	PROPN
admet-923	1664	28	ouderkirk	ouderkirk	PROPN
admet-923	1664	29	,	,	PUNCT
admet-923	1664	30	s.	s.	PROPN
admet-923	1664	31	bay	bay	PROPN
admet-923	1664	32	,	,	PUNCT
admet-923	1664	33	p.	p.	PROPN
admet-923	1664	34	sathe	sathe	PROPN
admet-923	1664	35	,	,	PUNCT
admet-923	1664	36	g.j.p	g.j.p	PROPN
admet-923	1664	37	.	.	PUNCT
admet-923	1665	1	singh	singh	PROPN
admet-923	1665	2	,	,	PUNCT
admet-923	1665	3	l.	l.	PROPN
admet-923	1665	4	iillman	iillman	PROPN
admet-923	1665	5	,	,	PUNCT
admet-923	1665	6	y.	y.	PROPN
admet-923	1665	7	tsong	tsong	PROPN
admet-923	1665	8	,	,	PUNCT
admet-923	1665	9	r.i	r.i	PROPN
admet-923	1665	10	.	.	PROPN
admet-923	1665	11	williams	williams	PROPN
admet-923	1665	12	.	.	PUNCT
admet-923	1666	1	fda	fda	PROPN
admet-923	1666	2	guidance	guidance	NOUN
admet-923	1666	3	for	for	ADP
admet-923	1666	4	industry	industry	NOUN
admet-923	1666	5	1	1	NUM
admet-923	1666	6	dissolution	dissolution	NOUN
admet-923	1666	7	testing	testing	NOUN
admet-923	1666	8	of	of	ADP
admet-923	1666	9	immediate	immediate	ADJ
admet-923	1666	10	release	release	NOUN
admet-923	1666	11	solid	solid	ADJ
admet-923	1666	12	oral	oral	ADJ
admet-923	1666	13	dosage	dosage	NOUN
admet-923	1666	14	forms	form	NOUN
admet-923	1666	15	.	.	PUNCT
admet-923	1667	1	dissolution	dissolution	ADJ
admet-923	1667	2	technol	technol	NOUN
admet-923	1667	3	.	.	PROPN
admet-923	1667	4	4	4	NUM
admet-923	1667	5	(	(	PUNCT
admet-923	1667	6	1997	1997	NUM
admet-923	1667	7	)	)	PUNCT
admet-923	1667	8	15–22	15–22	NUM
admet-923	1667	9	.	.	PUNCT
admet-923	1668	1	[	[	X
admet-923	1668	2	193	193	NUM
admet-923	1668	3	]	]	X
admet-923	1668	4	fda	fda	PROPN
admet-923	1668	5	.	.	PROPN
admet-923	1668	6	extended	extend	VERB
admet-923	1668	7	release	release	NOUN
admet-923	1668	8	oral	oral	ADJ
admet-923	1668	9	dosage	dosage	NOUN
admet-923	1668	10	forms	form	NOUN
admet-923	1668	11	:	:	PUNCT
admet-923	1668	12	development	development	NOUN
admet-923	1668	13	,	,	PUNCT
admet-923	1668	14	evaluation	evaluation	NOUN
admet-923	1668	15	,	,	PUNCT
admet-923	1668	16	and	and	CCONJ
admet-923	1668	17	application	application	NOUN
admet-923	1668	18	of	of	ADP
admet-923	1668	19	in	in	ADP
admet-923	1668	20	vitro	vitro	NOUN
admet-923	1668	21	/	/	SYM
admet-923	1668	22	in	in	ADP
admet-923	1668	23	vivo	vivo	NOUN
admet-923	1668	24	correlations	correlation	NOUN
admet-923	1668	25	.	.	PUNCT
admet-923	1669	1	(	(	PUNCT
admet-923	1669	2	1997	1997	NUM
admet-923	1669	3	)	)	PUNCT
admet-923	1669	4	1–24	1–24	PROPN
admet-923	1669	5	.	.	PUNCT
admet-923	1670	1	http://www.fda.gov/cder/guidance/index.htm	http://www.fda.gov/cder/guidance/index.htm	PROPN
admet-923	1670	2	.	.	PUNCT
admet-923	1671	1	[	[	X
admet-923	1671	2	194	194	NUM
admet-923	1671	3	]	]	X
admet-923	1671	4	venkata	venkata	PROPN
admet-923	1671	5	ramana	ramana	PROPN
admet-923	1671	6	s.	s.	PROPN
admet-923	1671	7	uppoor	uppoor	PROPN
admet-923	1671	8	.	.	PUNCT
admet-923	1672	1	regulatory	regulatory	ADJ
admet-923	1672	2	perspectives	perspective	NOUN
admet-923	1672	3	on	on	ADV
admet-923	1672	4	in	in	ADP
admet-923	1672	5	vitro	vitro	X
admet-923	1672	6	(	(	PUNCT
admet-923	1672	7	dissolution	dissolution	PROPN
admet-923	1672	8	)	)	PUNCT
admet-923	1672	9	/in	/in	PROPN
admet-923	1673	1	vivo	vivo	NOUN
admet-923	1673	2	(	(	PUNCT
admet-923	1673	3	bioavailability	bioavailability	NOUN
admet-923	1673	4	)	)	PUNCT
admet-923	1673	5	correlations	correlation	NOUN
admet-923	1673	6	.	.	PUNCT
admet-923	1674	1	j.	j.	PROPN
admet-923	1674	2	control	control	PROPN
admet-923	1674	3	.	.	PUNCT
admet-923	1675	1	release	release	NOUN
admet-923	1675	2	.	.	PUNCT
admet-923	1676	1	72	72	NUM
admet-923	1676	2	(	(	PUNCT
admet-923	1676	3	2001	2001	NUM
admet-923	1676	4	)	)	PUNCT
admet-923	1676	5	127–132	127–132	NUM
admet-923	1676	6	.	.	PUNCT
admet-923	1677	1	[	[	X
admet-923	1677	2	195	195	NUM
admet-923	1677	3	]	]	PUNCT
admet-923	1677	4	redc	redc	PROPN
admet-923	1677	5	/	/	SYM
admet-923	1677	6	adf	adf	PROPN
admet-923	1677	7	.	.	PUNCT
admet-923	1677	8	dissolution	dissolution	PROPN
admet-923	1677	9	testing	testing	NOUN
admet-923	1677	10	and	and	CCONJ
admet-923	1677	11	acceptance	acceptance	NOUN
admet-923	1677	12	criteria	criterion	NOUN
admet-923	1677	13	for	for	ADP
admet-923	1677	14	immediate	immediate	ADJ
admet-923	1677	15	-	-	PUNCT
admet-923	1677	16	release	release	NOUN
admet-923	1677	17	solid	solid	ADJ
admet-923	1677	18	oral	oral	ADJ
admet-923	1677	19	dosage	dosage	NOUN
admet-923	1677	20	form	form	NOUN
admet-923	1677	21	drug	drug	NOUN
admet-923	1677	22	products	product	NOUN
admet-923	1677	23	containing	contain	VERB
admet-923	1677	24	high	high	ADJ
admet-923	1677	25	solubility	solubility	NOUN
admet-923	1677	26	drug	drug	NOUN
admet-923	1677	27	substances	substance	NOUN
admet-923	1677	28	guidance	guidance	NOUN
admet-923	1677	29	for	for	ADP
admet-923	1677	30	industry	industry	NOUN
admet-923	1677	31	.	.	PUNCT
admet-923	1678	1	fda	fda	PROPN
admet-923	1678	2	.	.	PUNCT
admet-923	1679	1	(	(	PUNCT
admet-923	1679	2	2018	2018	NUM
admet-923	1679	3	)	)	PUNCT
admet-923	1679	4	august	august	PROPN
admet-923	1679	5	-	-	PUNCT
admet-923	1679	6	august	august	PROPN
admet-923	1679	7	.	.	PUNCT
admet-923	1680	1	©	©	PROPN
admet-923	1680	2	2021	2021	NUM
admet-923	1680	3	by	by	ADP
admet-923	1680	4	the	the	DET
admet-923	1680	5	authors	author	NOUN
admet-923	1680	6	;	;	PUNCT
admet-923	1680	7	licensee	licensee	PROPN
admet-923	1680	8	iapc	iapc	PROPN
admet-923	1680	9	,	,	PUNCT
admet-923	1680	10	zagreb	zagreb	PROPN
admet-923	1680	11	,	,	PUNCT
admet-923	1680	12	croatia	croatia	PROPN
admet-923	1680	13	.	.	PUNCT
admet-923	1681	1	this	this	DET
admet-923	1681	2	article	article	NOUN
admet-923	1681	3	is	be	AUX
admet-923	1681	4	an	an	DET
admet-923	1681	5	open	open	ADJ
admet-923	1681	6	-	-	PUNCT
admet-923	1681	7	access	access	NOUN
admet-923	1681	8	article	article	NOUN
admet-923	1681	9	distributed	distribute	VERB
admet-923	1681	10	under	under	ADP
admet-923	1681	11	the	the	DET
admet-923	1681	12	terms	term	NOUN
admet-923	1681	13	and	and	CCONJ
admet-923	1681	14	conditions	condition	NOUN
admet-923	1681	15	of	of	ADP
admet-923	1681	16	the	the	DET
admet-923	1681	17	creative	creative	ADJ
admet-923	1681	18	commons	common	NOUN
admet-923	1681	19	attribution	attribution	NOUN
admet-923	1681	20	license	license	NOUN
admet-923	1681	21	(	(	PUNCT
admet-923	1681	22	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
admet-923	1681	23	)	)	PUNCT
admet-923	1681	24	https://doi.org/10.5599/admet.923	https://doi.org/10.5599/admet.923	X
admet-923	1681	25	http://www.fda.gov/cder/guidance/index.htm	http://www.fda.gov/cder/guidance/index.htm	PROPN
admet-923	1681	26	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN