id	sid	tid	token	lemma	pos
admet-929	1	1	biomimetic	biomimetic	ADJ
admet-929	1	2	properties	property	NOUN
admet-929	1	3	and	and	CCONJ
admet-929	1	4	estimated	estimate	VERB
admet-929	1	5	in	in	ADP
admet-929	1	6	vivo	vivo	ADJ
admet-929	1	7	distribution	distribution	NOUN
admet-929	1	8	of	of	ADP
admet-929	1	9	chloroquine	chloroquine	NOUN
admet-929	1	10	and	and	CCONJ
admet-929	1	11	hydroxy	hydroxy	PROPN
admet-929	1	12	-	-	PUNCT
admet-929	1	13	chloroquine	chloroquine	NOUN
admet-929	1	14	enantiomers	enantiomer	NOUN
admet-929	1	15	doi	doi	NOUN
admet-929	1	16	:	:	PUNCT
admet-929	1	17	https://doi.org/10.5599/admet.929	https://doi.org/10.5599/admet.929	NOUN
admet-929	1	18	151	151	NUM
admet-929	1	19	admet	admet	X
admet-929	1	20	&	&	CCONJ
admet-929	1	21	dmpk	dmpk	PROPN
admet-929	1	22	9(2	9(2	NUM
admet-929	1	23	)	)	PUNCT
admet-929	1	24	(	(	PUNCT
admet-929	1	25	2021	2021	NUM
admet-929	1	26	)	)	PUNCT
admet-929	1	27	151	151	NUM
admet-929	1	28	-	-	SYM
admet-929	1	29	165	165	NUM
admet-929	1	30	;	;	PUNCT
admet-929	1	31	doi	doi	NOUN
admet-929	1	32	:	:	PUNCT
admet-929	1	33	https://dx.doi.org/10.5599/admet.929	https://dx.doi.org/10.5599/admet.929	NOUN
admet-929	1	34	open	open	ADJ
admet-929	1	35	access	access	NOUN
admet-929	1	36	:	:	PUNCT
admet-929	1	37	issn	issn	PROPN
admet-929	1	38	:	:	PUNCT
admet-929	1	39	1848	1848	NUM
admet-929	1	40	-	-	SYM
admet-929	1	41	7718	7718	NUM
admet-929	1	42	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-929	1	43	original	original	ADJ
admet-929	1	44	scientific	scientific	ADJ
admet-929	1	45	paper	paper	NOUN
admet-929	1	46	biomimetic	biomimetic	ADJ
admet-929	1	47	properties	property	NOUN
admet-929	1	48	and	and	CCONJ
admet-929	1	49	estimated	estimate	VERB
admet-929	1	50	in	in	ADP
admet-929	1	51	vivo	vivo	ADJ
admet-929	1	52	distribution	distribution	NOUN
admet-929	1	53	of	of	ADP
admet-929	1	54	chloroquine	chloroquine	NOUN
admet-929	1	55	and	and	CCONJ
admet-929	1	56	hydroxy	hydroxy	PROPN
admet-929	1	57	-	-	PUNCT
admet-929	1	58	chloroquine	chloroquine	NOUN
admet-929	1	59	enantiomers	enantiomer	NOUN
admet-929	1	60	klara	klara	PROPN
admet-929	1	61	l	l	PROPN
admet-929	1	62	valko*1	valko*1	PROPN
admet-929	1	63	and	and	CCONJ
admet-929	1	64	tong	tong	PROPN
admet-929	1	65	zhang2	zhang2	PROPN
admet-929	2	1	1bio	1bio	ADV
admet-929	2	2	-	-	PUNCT
admet-929	2	3	mimetic	mimetic	ADJ
admet-929	2	4	chromatography	chromatography	NOUN
admet-929	2	5	ltd	ltd	PROPN
admet-929	2	6	,	,	PUNCT
admet-929	2	7	business	business	PROPN
admet-929	2	8	&	&	CCONJ
admet-929	2	9	technology	technology	PROPN
admet-929	2	10	centre	centre	PROPN
admet-929	2	11	,	,	PUNCT
admet-929	2	12	bessemer	bessemer	PROPN
admet-929	2	13	drive	drive	PROPN
admet-929	2	14	,	,	PUNCT
admet-929	2	15	stevenage	stevenage	PROPN
admet-929	2	16	,	,	PUNCT
admet-929	2	17	herts	herts	PROPN
admet-929	2	18	sg1	sg1	PROPN
admet-929	2	19	2dx	2dx	PROPN
admet-929	2	20	uk	uk	PROPN
admet-929	2	21	2	2	NUM
admet-929	2	22	chiral	chiral	ADJ
admet-929	2	23	technologies	technology	NOUN
admet-929	2	24	europe	europe	PROPN
admet-929	2	25	,	,	PUNCT
admet-929	2	26	parc	parc	PROPN
admet-929	2	27	d'innovation	d'innovation	PROPN
admet-929	2	28	160	160	NUM
admet-929	2	29	,	,	PUNCT
admet-929	2	30	bd	bd	PROPN
admet-929	2	31	gonthier	gonthier	PROPN
admet-929	2	32	d'andernach	d'andernach	PROPN
admet-929	2	33	cs	cs	PROPN
admet-929	2	34	80140	80140	NUM
admet-929	2	35	67404	67404	NUM
admet-929	2	36	illkirch	illkirch	PROPN
admet-929	2	37	cedex	cedex	PROPN
admet-929	2	38	france	france	PROPN
admet-929	2	39	*	*	PUNCT
admet-929	2	40	corresponding	correspond	VERB
admet-929	2	41	author	author	NOUN
admet-929	2	42	:	:	PUNCT
admet-929	2	43	e	e	NOUN
admet-929	2	44	-	-	NOUN
admet-929	2	45	mail	mail	NOUN
admet-929	2	46	:	:	PUNCT
admet-929	2	47	klara_valko@bio-mimetic-chromatography.com	klara_valko@bio-mimetic-chromatography.com	NOUN
admet-929	2	48	;	;	PUNCT
admet-929	2	49	tel	tel	PROPN
admet-929	2	50	.	.	PUNCT
admet-929	2	51	:	:	PUNCT
admet-929	3	1	+44	+44	PROPN
admet-929	3	2	-	-	PUNCT
admet-929	3	3	7521	7521	NUM
admet-929	3	4	-	-	SYM
admet-929	3	5	989558	989558	NUM
admet-929	3	6	;	;	PUNCT
admet-929	3	7	received	receive	VERB
admet-929	3	8	:	:	PUNCT
admet-929	3	9	november	november	PROPN
admet-929	3	10	16	16	NUM
admet-929	3	11	,	,	PUNCT
admet-929	3	12	2020	2020	NUM
admet-929	3	13	;	;	PUNCT
admet-929	3	14	revised	revise	VERB
admet-929	3	15	:	:	PUNCT
admet-929	3	16	january	january	PROPN
admet-929	3	17	10	10	NUM
admet-929	3	18	,	,	PUNCT
admet-929	3	19	2021	2021	NUM
admet-929	3	20	;	;	PUNCT
admet-929	3	21	published	publish	VERB
admet-929	3	22	online	online	ADV
admet-929	3	23	:	:	PUNCT
admet-929	3	24	january	january	PROPN
admet-929	3	25	25	25	NUM
admet-929	3	26	,	,	PUNCT
admet-929	3	27	2020	2020	NUM
admet-929	3	28	abstract	abstract	ADJ
admet-929	3	29	chloroquine	chloroquine	NOUN
admet-929	3	30	and	and	CCONJ
admet-929	3	31	hydroxy	hydroxy	PROPN
admet-929	3	32	-	-	PUNCT
admet-929	3	33	chloroquine	chloroquine	NOUN
admet-929	3	34	already	already	ADV
admet-929	3	35	established	establish	VERB
admet-929	3	36	as	as	ADP
admet-929	3	37	anti	anti	ADJ
admet-929	3	38	-	-	ADJ
admet-929	3	39	malarial	malarial	ADJ
admet-929	3	40	and	and	CCONJ
admet-929	3	41	lupus	lupus	ADJ
admet-929	3	42	drugs	drug	NOUN
admet-929	3	43	have	have	AUX
admet-929	3	44	recently	recently	ADV
admet-929	3	45	gained	gain	VERB
admet-929	3	46	renewed	renew	VERB
admet-929	3	47	attention	attention	NOUN
admet-929	3	48	in	in	ADP
admet-929	3	49	the	the	DET
admet-929	3	50	fight	fight	NOUN
admet-929	3	51	against	against	ADP
admet-929	3	52	the	the	DET
admet-929	3	53	covid-19	covid-19	PROPN
admet-929	3	54	pandemic	pandemic	NOUN
admet-929	3	55	.	.	PUNCT
admet-929	4	1	bio	bio	ADJ
admet-929	4	2	-	-	ADJ
admet-929	4	3	mimetic	mimetic	ADJ
admet-929	4	4	hplc	hplc	NOUN
admet-929	4	5	methods	method	NOUN
admet-929	4	6	have	have	AUX
admet-929	4	7	been	be	AUX
admet-929	4	8	used	use	VERB
admet-929	4	9	to	to	PART
admet-929	4	10	measure	measure	VERB
admet-929	4	11	the	the	DET
admet-929	4	12	protein	protein	NOUN
admet-929	4	13	and	and	CCONJ
admet-929	4	14	phospholipid	phospholipid	NOUN
admet-929	4	15	binding	bind	VERB
admet-929	4	16	of	of	ADP
admet-929	4	17	the	the	DET
admet-929	4	18	racemic	racemic	ADJ
admet-929	4	19	mixtures	mixture	NOUN
admet-929	4	20	of	of	ADP
admet-929	4	21	the	the	DET
admet-929	4	22	drugs	drug	NOUN
admet-929	4	23	.	.	PUNCT
admet-929	5	1	the	the	DET
admet-929	5	2	tissue	tissue	NOUN
admet-929	5	3	binding	bind	VERB
admet-929	5	4	and	and	CCONJ
admet-929	5	5	volume	volume	NOUN
admet-929	5	6	of	of	ADP
admet-929	5	7	distribution	distribution	NOUN
admet-929	5	8	of	of	ADP
admet-929	5	9	the	the	DET
admet-929	5	10	enantiomers	enantiomer	NOUN
admet-929	5	11	have	have	AUX
admet-929	5	12	been	be	AUX
admet-929	5	13	estimated	estimate	VERB
admet-929	5	14	.	.	PUNCT
admet-929	6	1	the	the	DET
admet-929	6	2	enantiomers	enantiomer	NOUN
admet-929	6	3	can	can	AUX
admet-929	6	4	be	be	AUX
admet-929	6	5	separated	separate	VERB
admet-929	6	6	using	use	VERB
admet-929	6	7	chiralpak	chiralpak	PROPN
admet-929	6	8	agp	agp	PROPN
admet-929	6	9	hplc	hplc	NOUN
admet-929	6	10	columns	column	NOUN
admet-929	6	11	.	.	PUNCT
admet-929	7	1	from	from	ADP
admet-929	7	2	the	the	DET
admet-929	7	3	α-1	α-1	NOUN
admet-929	7	4	-	-	PUNCT
admet-929	7	5	acid	acid	NOUN
admet-929	7	6	-	-	PUNCT
admet-929	7	7	glycoprotein	glycoprotein	NOUN
admet-929	7	8	(	(	PUNCT
admet-929	7	9	agp	agp	NOUN
admet-929	7	10	)	)	PUNCT
admet-929	7	11	binding	binding	NOUN
admet-929	7	12	,	,	PUNCT
admet-929	7	13	the	the	DET
admet-929	7	14	lung	lung	NOUN
admet-929	7	15	tissue	tissue	NOUN
admet-929	7	16	binding	bind	VERB
admet-929	7	17	can	can	AUX
admet-929	7	18	be	be	AUX
admet-929	7	19	estimated	estimate	VERB
admet-929	7	20	for	for	ADP
admet-929	7	21	the	the	DET
admet-929	7	22	enantiomers	enantiomer	NOUN
admet-929	7	23	.	.	PUNCT
admet-929	8	1	the	the	DET
admet-929	8	2	drugs	drug	NOUN
admet-929	8	3	have	have	VERB
admet-929	8	4	a	a	DET
admet-929	8	5	large	large	ADJ
admet-929	8	6	volume	volume	NOUN
admet-929	8	7	of	of	ADP
admet-929	8	8	distribution	distribution	NOUN
admet-929	8	9	,	,	PUNCT
admet-929	8	10	showed	show	VERB
admet-929	8	11	strong	strong	ADJ
admet-929	8	12	and	and	CCONJ
admet-929	8	13	stereoselective	stereoselective	ADJ
admet-929	8	14	glycoprotein	glycoprotein	NOUN
admet-929	8	15	binding	bind	VERB
admet-929	8	16	,	,	PUNCT
admet-929	8	17	medium	medium	ADJ
admet-929	8	18	-	-	PUNCT
admet-929	8	19	strong	strong	ADJ
admet-929	8	20	phospholipid	phospholipid	NOUN
admet-929	8	21	-	-	PUNCT
admet-929	8	22	binding	bind	VERB
admet-929	8	23	indicating	indicate	VERB
admet-929	8	24	only	only	ADV
admet-929	8	25	moderate	moderate	ADJ
admet-929	8	26	phospholipidotic	phospholipidotic	ADJ
admet-929	8	27	potential	potential	NOUN
admet-929	8	28	,	,	PUNCT
admet-929	8	29	herg	herg	PROPN
admet-929	8	30	inhibition	inhibition	NOUN
admet-929	8	31	and	and	CCONJ
admet-929	8	32	promiscuous	promiscuous	ADJ
admet-929	8	33	binding	binding	NOUN
admet-929	8	34	.	.	PUNCT
admet-929	9	1	the	the	DET
admet-929	9	2	drug	drug	NOUN
admet-929	9	3	efficiency	efficiency	NOUN
admet-929	9	4	of	of	ADP
admet-929	9	5	the	the	DET
admet-929	9	6	compounds	compound	NOUN
admet-929	9	7	was	be	AUX
admet-929	9	8	estimated	estimate	VERB
admet-929	9	9	to	to	PART
admet-929	9	10	be	be	AUX
admet-929	9	11	greater	great	ADJ
admet-929	9	12	than	than	ADP
admet-929	9	13	2	2	NUM
admet-929	9	14	%	%	NOUN
admet-929	9	15	which	which	PRON
admet-929	9	16	indicates	indicate	VERB
admet-929	9	17	a	a	DET
admet-929	9	18	high	high	ADJ
admet-929	9	19	level	level	NOUN
admet-929	9	20	of	of	ADP
admet-929	9	21	free	free	ADJ
admet-929	9	22	biophase	biophase	NOUN
admet-929	9	23	concentration	concentration	NOUN
admet-929	9	24	relative	relative	ADJ
admet-929	9	25	to	to	AUX
admet-929	9	26	dose	dose	PROPN
admet-929	9	27	.	.	PUNCT
admet-929	10	1	the	the	DET
admet-929	10	2	biomimetic	biomimetic	ADJ
admet-929	10	3	properties	property	NOUN
admet-929	10	4	of	of	ADP
admet-929	10	5	the	the	DET
admet-929	10	6	compounds	compound	NOUN
admet-929	10	7	support	support	VERB
admet-929	10	8	the	the	DET
admet-929	10	9	well	well	ADV
admet-929	10	10	-	-	PUNCT
admet-929	10	11	known	know	VERB
admet-929	10	12	tolerability	tolerability	NOUN
admet-929	10	13	of	of	ADP
admet-929	10	14	the	the	DET
admet-929	10	15	drugs	drug	NOUN
admet-929	10	16	.	.	PUNCT
admet-929	11	1	©	©	NOUN
admet-929	11	2	2021	2021	NUM
admet-929	11	3	by	by	ADP
admet-929	11	4	the	the	DET
admet-929	11	5	authors	author	NOUN
admet-929	11	6	.	.	PUNCT
admet-929	12	1	this	this	DET
admet-929	12	2	article	article	NOUN
admet-929	12	3	is	be	AUX
admet-929	12	4	an	an	DET
admet-929	12	5	open	open	ADJ
admet-929	12	6	-	-	PUNCT
admet-929	12	7	access	access	NOUN
admet-929	12	8	article	article	NOUN
admet-929	12	9	distributed	distribute	VERB
admet-929	12	10	under	under	ADP
admet-929	12	11	the	the	DET
admet-929	12	12	terms	term	NOUN
admet-929	12	13	and	and	CCONJ
admet-929	12	14	conditions	condition	NOUN
admet-929	12	15	of	of	ADP
admet-929	12	16	the	the	DET
admet-929	12	17	creative	creative	ADJ
admet-929	12	18	commons	common	NOUN
admet-929	12	19	attribution	attribution	NOUN
admet-929	12	20	license	license	NOUN
admet-929	12	21	(	(	PUNCT
admet-929	12	22	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-929	12	23	)	)	PUNCT
admet-929	12	24	.	.	PUNCT
admet-929	13	1	keywords	keyword	VERB
admet-929	13	2	protein	protein	NOUN
admet-929	13	3	binding	bind	VERB
admet-929	13	4	;	;	PUNCT
admet-929	13	5	chiral	chiral	ADJ
admet-929	13	6	separation	separation	NOUN
admet-929	13	7	;	;	PUNCT
admet-929	13	8	chloroquine	chloroquine	NOUN
admet-929	13	9	and	and	CCONJ
admet-929	13	10	hydroxy	hydroxy	PROPN
admet-929	13	11	-	-	PUNCT
admet-929	13	12	chloroquine	chloroquine	NOUN
admet-929	13	13	;	;	PUNCT
admet-929	13	14	tissue	tissue	NOUN
admet-929	13	15	binding	binding	NOUN
admet-929	13	16	;	;	PUNCT
admet-929	13	17	the	the	DET
admet-929	13	18	volume	volume	NOUN
admet-929	13	19	of	of	ADP
admet-929	13	20	distribution	distribution	NOUN
admet-929	13	21	introduction	introduction	NOUN
admet-929	13	22	chloroquine	chloroquine	NOUN
admet-929	13	23	(	(	PUNCT
admet-929	13	24	cq	cq	NOUN
admet-929	13	25	)	)	PUNCT
admet-929	13	26	and	and	CCONJ
admet-929	13	27	hydroxy	hydroxy	PROPN
admet-929	13	28	-	-	PUNCT
admet-929	13	29	chloroquine	chloroquine	NOUN
admet-929	13	30	(	(	PUNCT
admet-929	13	31	hcq	hcq	NOUN
admet-929	13	32	)	)	PUNCT
admet-929	13	33	are	be	AUX
admet-929	13	34	well	well	ADV
admet-929	13	35	established	establish	VERB
admet-929	13	36	for	for	ADP
admet-929	13	37	the	the	DET
admet-929	13	38	treatment	treatment	NOUN
admet-929	13	39	of	of	ADP
admet-929	13	40	malaria	malaria	NOUN
admet-929	13	41	,	,	PUNCT
admet-929	13	42	rheumatoid	rheumatoid	NOUN
admet-929	13	43	arthritis	arthritis	NOUN
admet-929	13	44	,	,	PUNCT
admet-929	13	45	and	and	CCONJ
admet-929	13	46	lupus	lupus	NOUN
admet-929	13	47	.	.	PUNCT
admet-929	14	1	cq	cq	PROPN
admet-929	14	2	was	be	AUX
admet-929	14	3	first	first	ADV
admet-929	14	4	synthesised	synthesise	VERB
admet-929	14	5	in	in	ADP
admet-929	14	6	1934	1934	NUM
admet-929	14	7	by	by	ADP
admet-929	14	8	hans	han	NOUN
admet-929	14	9	andersag	andersag	ADJ
admet-929	14	10	at	at	ADP
admet-929	14	11	bayer	bayer	PROPN
admet-929	14	12	in	in	ADP
admet-929	14	13	elberfeld	elberfeld	PROPN
admet-929	14	14	germany	germany	PROPN
admet-929	14	15	,	,	PUNCT
admet-929	14	16	by	by	ADP
admet-929	14	17	modifying	modify	VERB
admet-929	14	18	the	the	DET
admet-929	14	19	chemical	chemical	ADJ
admet-929	14	20	structure	structure	NOUN
admet-929	14	21	of	of	ADP
admet-929	14	22	quinine	quinine	PROPN
admet-929	14	23	an	an	DET
admet-929	14	24	anti	anti	ADJ
admet-929	14	25	-	-	ADJ
admet-929	14	26	malarial	malarial	ADJ
admet-929	14	27	natural	natural	ADJ
admet-929	14	28	alkaloid	alkaloid	NOUN
admet-929	15	1	[	[	X
admet-929	15	2	1	1	NUM
admet-929	15	3	]	]	PUNCT
admet-929	15	4	.	.	PUNCT
admet-929	16	1	during	during	ADP
admet-929	16	2	the	the	DET
admet-929	16	3	second	second	ADJ
admet-929	16	4	world	world	NOUN
admet-929	16	5	war	war	NOUN
admet-929	16	6	,	,	PUNCT
admet-929	16	7	when	when	SCONJ
admet-929	16	8	millions	million	NOUN
admet-929	16	9	of	of	ADP
admet-929	16	10	soldiers	soldier	NOUN
admet-929	16	11	were	be	AUX
admet-929	16	12	taking	take	VERB
admet-929	16	13	cq	cq	ADV
admet-929	16	14	for	for	ADP
admet-929	16	15	malaria	malaria	NOUN
admet-929	16	16	prevention	prevention	NOUN
admet-929	16	17	,	,	PUNCT
admet-929	16	18	its	its	PRON
admet-929	16	19	beneficial	beneficial	ADJ
admet-929	16	20	effects	effect	NOUN
admet-929	16	21	were	be	AUX
admet-929	16	22	discovered	discover	VERB
admet-929	16	23	in	in	ADP
admet-929	16	24	the	the	DET
admet-929	16	25	treatment	treatment	NOUN
admet-929	16	26	of	of	ADP
admet-929	16	27	rheumatoid	rheumatoid	NOUN
admet-929	16	28	arthritis	arthritis	NOUN
admet-929	16	29	(	(	PUNCT
admet-929	16	30	ra	ra	NOUN
admet-929	16	31	)	)	PUNCT
admet-929	16	32	and	and	CCONJ
admet-929	16	33	systemic	systemic	ADJ
admet-929	16	34	lupus	lupus	PROPN
admet-929	16	35	erythematosus	erythematosus	NOUN
admet-929	16	36	(	(	PUNCT
admet-929	16	37	sle	sle	PROPN
admet-929	16	38	)	)	PUNCT
admet-929	16	39	.	.	PUNCT
admet-929	17	1	when	when	SCONJ
admet-929	17	2	the	the	DET
admet-929	17	3	resistance	resistance	NOUN
admet-929	17	4	of	of	ADP
admet-929	17	5	cq	cq	NOUN
admet-929	17	6	against	against	ADP
admet-929	17	7	malaria	malaria	NOUN
admet-929	17	8	plasmids	plasmid	NOUN
admet-929	17	9	became	become	VERB
admet-929	17	10	apparent	apparent	ADJ
admet-929	17	11	,	,	PUNCT
admet-929	17	12	the	the	DET
admet-929	17	13	search	search	NOUN
admet-929	17	14	for	for	ADP
admet-929	17	15	analogues	analogue	NOUN
admet-929	17	16	resulted	result	VERB
admet-929	17	17	in	in	ADP
admet-929	17	18	the	the	DET
admet-929	17	19	discovery	discovery	NOUN
admet-929	17	20	of	of	ADP
admet-929	17	21	hcq	hcq	NOUN
admet-929	17	22	in	in	ADP
admet-929	17	23	1945	1945	NUM
admet-929	17	24	[	[	X
admet-929	17	25	1	1	NUM
admet-929	17	26	]	]	PUNCT
admet-929	17	27	.	.	PUNCT
admet-929	18	1	the	the	DET
admet-929	18	2	activity	activity	NOUN
admet-929	18	3	of	of	ADP
admet-929	18	4	cq	cq	NOUN
admet-929	18	5	against	against	ADP
admet-929	18	6	viruses	virus	NOUN
admet-929	18	7	was	be	AUX
admet-929	18	8	first	first	ADV
admet-929	18	9	reported	report	VERB
admet-929	18	10	in	in	ADP
admet-929	18	11	1972	1972	NUM
admet-929	18	12	.	.	PUNCT
admet-929	19	1	by	by	ADP
admet-929	19	2	shimizu	shimizu	PROPN
admet-929	19	3	et	et	PROPN
admet-929	19	4	al	al	PROPN
admet-929	19	5	.	.	PUNCT
admet-929	20	1	[	[	X
admet-929	20	2	2	2	NUM
admet-929	20	3	]	]	PUNCT
admet-929	20	4	.	.	PUNCT
admet-929	21	1	more	more	ADJ
admet-929	21	2	than	than	ADP
admet-929	21	3	ten	ten	NUM
admet-929	21	4	years	year	NOUN
admet-929	21	5	ago	ago	ADV
admet-929	21	6	,	,	PUNCT
admet-929	21	7	cq	cq	PROPN
admet-929	21	8	was	be	AUX
admet-929	21	9	proposed	propose	VERB
admet-929	21	10	as	as	ADP
admet-929	21	11	a	a	DET
admet-929	21	12	broad	broad	ADJ
admet-929	21	13	-	-	PUNCT
admet-929	21	14	spectrum	spectrum	NOUN
admet-929	21	15	antimicrobial	antimicrobial	ADJ
admet-929	21	16	agent	agent	NOUN
admet-929	21	17	against	against	ADP
admet-929	21	18	bacteria	bacteria	NOUN
admet-929	21	19	,	,	PUNCT
admet-929	21	20	fungal	fungal	ADJ
admet-929	21	21	and	and	CCONJ
admet-929	21	22	viral	viral	ADJ
admet-929	21	23	infections	infection	NOUN
admet-929	21	24	[	[	X
admet-929	21	25	3	3	NUM
admet-929	21	26	]	]	PUNCT
admet-929	21	27	.	.	PUNCT
admet-929	22	1	in	in	ADP
admet-929	22	2	december	december	PROPN
admet-929	22	3	2019	2019	NUM
admet-929	22	4	,	,	PUNCT
admet-929	22	5	an	an	DET
admet-929	22	6	outbreak	outbreak	NOUN
admet-929	22	7	of	of	ADP
admet-929	22	8	pneumonia	pneumonia	NOUN
admet-929	22	9	of	of	ADP
admet-929	22	10	unknown	unknown	ADJ
admet-929	22	11	aetiology	aetiology	NOUN
admet-929	22	12	was	be	AUX
admet-929	22	13	reported	report	VERB
admet-929	22	14	in	in	ADP
admet-929	22	15	wuhan	wuhan	PROPN
admet-929	22	16	,	,	PUNCT
admet-929	22	17	china	china	PROPN
admet-929	23	1	[	[	X
admet-929	23	2	4,5	4,5	NUM
admet-929	23	3	]	]	PUNCT
admet-929	23	4	.	.	PUNCT
admet-929	24	1	this	this	DET
admet-929	24	2	disease	disease	NOUN
admet-929	24	3	problem	problem	NOUN
admet-929	24	4	was	be	AUX
admet-929	24	5	then	then	ADV
admet-929	24	6	declared	declare	VERB
admet-929	24	7	as	as	ADP
admet-929	24	8	a	a	DET
admet-929	24	9	pandemic	pandemic	NOUN
admet-929	24	10	by	by	ADP
admet-929	24	11	https://doi.org/10.5599/admet.929	https://doi.org/10.5599/admet.929	NOUN
admet-929	24	12	https://dx.doi.org/10.5599/admet.929	https://dx.doi.org/10.5599/admet.929	NOUN
admet-929	25	1	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	PROPN
admet-929	25	2	mailto:klara_valko@bio-mimetic-chromatography.com	mailto:klara_valko@bio-mimetic-chromatography.com	X
admet-929	25	3	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-929	25	4	klara	klara	PROPN
admet-929	25	5	valko	valko	PROPN
admet-929	25	6	and	and	CCONJ
admet-929	25	7	tong	tong	PROPN
admet-929	25	8	zhang	zhang	PROPN
admet-929	25	9	admet	admet	PROPN
admet-929	25	10	&	&	CCONJ
admet-929	25	11	dmpk	dmpk	PROPN
admet-929	25	12	9(2	9(2	NUM
admet-929	25	13	)	)	PUNCT
admet-929	25	14	(	(	PUNCT
admet-929	25	15	2021	2021	NUM
admet-929	25	16	)	)	PUNCT
admet-929	25	17	151	151	NUM
admet-929	25	18	-	-	SYM
admet-929	25	19	165	165	NUM
admet-929	25	20	152	152	NUM
admet-929	25	21	the	the	DET
admet-929	25	22	world	world	PROPN
admet-929	25	23	health	health	NOUN
admet-929	25	24	organization	organization	NOUN
admet-929	25	25	(	(	PUNCT
admet-929	25	26	who	who	PRON
admet-929	25	27	)	)	PUNCT
admet-929	25	28	on	on	ADP
admet-929	25	29	the	the	DET
admet-929	25	30	11th	11th	ADJ
admet-929	25	31	march	march	NOUN
admet-929	25	32	2020	2020	NUM
admet-929	25	33	.	.	PUNCT
admet-929	26	1	the	the	DET
admet-929	26	2	coronavirus	coronavirus	NOUN
admet-929	26	3	was	be	AUX
admet-929	26	4	identified	identify	VERB
admet-929	26	5	as	as	ADP
admet-929	26	6	the	the	DET
admet-929	26	7	cause	cause	NOUN
admet-929	26	8	of	of	ADP
admet-929	26	9	this	this	DET
admet-929	26	10	respiratory	respiratory	ADJ
admet-929	26	11	syndrome	syndrome	NOUN
admet-929	26	12	,	,	PUNCT
admet-929	26	13	and	and	CCONJ
admet-929	26	14	it	it	PRON
admet-929	26	15	was	be	AUX
admet-929	26	16	named	name	VERB
admet-929	26	17	sars	sar	NOUN
admet-929	26	18	-	-	PUNCT
admet-929	26	19	cov-2	cov-2	NOUN
admet-929	26	20	.	.	PUNCT
admet-929	27	1	the	the	DET
admet-929	27	2	disease	disease	NOUN
admet-929	27	3	that	that	PRON
admet-929	27	4	it	it	PRON
admet-929	27	5	caused	cause	VERB
admet-929	27	6	was	be	AUX
admet-929	27	7	named	name	VERB
admet-929	27	8	covid19	covid19	NOUN
admet-929	27	9	.	.	PUNCT
admet-929	28	1	since	since	SCONJ
admet-929	28	2	then	then	ADV
admet-929	28	3	,	,	PUNCT
admet-929	28	4	attention	attention	NOUN
admet-929	28	5	has	have	AUX
admet-929	28	6	been	be	AUX
admet-929	28	7	given	give	VERB
admet-929	28	8	to	to	ADP
admet-929	28	9	the	the	DET
admet-929	28	10	use	use	NOUN
admet-929	28	11	of	of	ADP
admet-929	28	12	cq	cq	NOUN
admet-929	28	13	and	and	CCONJ
admet-929	28	14	hcq	hcq	NOUN
admet-929	28	15	as	as	ADP
admet-929	28	16	potential	potential	ADJ
admet-929	28	17	treatments	treatment	NOUN
admet-929	28	18	for	for	ADP
admet-929	28	19	covid-19	covid-19	PROPN
admet-929	28	20	.	.	PUNCT
admet-929	29	1	the	the	DET
admet-929	29	2	various	various	ADJ
admet-929	29	3	mechanisms	mechanism	NOUN
admet-929	29	4	by	by	ADP
admet-929	29	5	which	which	PRON
admet-929	29	6	cq	cq	NOUN
admet-929	29	7	and	and	CCONJ
admet-929	29	8	hcq	hcq	NOUN
admet-929	29	9	may	may	AUX
admet-929	29	10	be	be	AUX
admet-929	29	11	involved	involve	VERB
admet-929	29	12	in	in	ADP
admet-929	29	13	their	their	PRON
admet-929	29	14	antiviral	antiviral	ADJ
admet-929	29	15	effects	effect	NOUN
admet-929	29	16	have	have	AUX
admet-929	29	17	been	be	AUX
admet-929	29	18	reviewed	review	VERB
admet-929	29	19	recently	recently	ADV
admet-929	29	20	[	[	X
admet-929	29	21	6	6	NUM
admet-929	29	22	]	]	PUNCT
admet-929	29	23	as	as	ADP
admet-929	29	24	a	a	DET
admet-929	29	25	result	result	NOUN
admet-929	29	26	of	of	ADP
admet-929	29	27	increased	increase	VERB
admet-929	29	28	interest	interest	NOUN
admet-929	29	29	due	due	ADP
admet-929	29	30	to	to	ADP
admet-929	29	31	the	the	DET
admet-929	29	32	covid-19	covid-19	PROPN
admet-929	29	33	pandemic	pandemic	NOUN
admet-929	29	34	.	.	PUNCT
admet-929	30	1	potential	potential	ADJ
admet-929	30	2	mechanisms	mechanism	NOUN
admet-929	30	3	include	include	VERB
admet-929	30	4	prevention	prevention	NOUN
admet-929	30	5	of	of	ADP
admet-929	30	6	the	the	DET
admet-929	30	7	virus	virus	NOUN
admet-929	30	8	entering	enter	VERB
admet-929	30	9	the	the	DET
admet-929	30	10	cells	cell	NOUN
admet-929	30	11	,	,	PUNCT
admet-929	30	12	altering	alter	VERB
admet-929	30	13	virus	virus	NOUN
admet-929	30	14	replication	replication	NOUN
admet-929	30	15	,	,	PUNCT
admet-929	30	16	inhibiting	inhibit	VERB
admet-929	30	17	autophagy	autophagy	NOUN
admet-929	30	18	and	and	CCONJ
admet-929	30	19	modulating	modulate	VERB
admet-929	30	20	the	the	DET
admet-929	30	21	immune	immune	ADJ
admet-929	30	22	response	response	NOUN
admet-929	30	23	.	.	PUNCT
admet-929	31	1	an	an	DET
admet-929	31	2	interesting	interesting	ADJ
admet-929	31	3	antiviral	antiviral	ADJ
admet-929	31	4	mechanism	mechanism	NOUN
admet-929	31	5	of	of	ADP
admet-929	31	6	cq	cq	NOUN
admet-929	31	7	and	and	CCONJ
admet-929	31	8	hcq	hcq	NOUN
admet-929	31	9	is	be	AUX
admet-929	31	10	that	that	SCONJ
admet-929	31	11	they	they	PRON
admet-929	31	12	allow	allow	VERB
admet-929	31	13	zn	zn	PROPN
admet-929	31	14	ions	ion	NOUN
admet-929	31	15	to	to	PART
admet-929	31	16	enter	enter	VERB
admet-929	31	17	the	the	DET
admet-929	31	18	cell	cell	NOUN
admet-929	31	19	and	and	CCONJ
admet-929	31	20	act	act	VERB
admet-929	31	21	as	as	ADP
admet-929	31	22	zinc	zinc	NOUN
admet-929	31	23	ionophores	ionophore	NOUN
admet-929	31	24	[	[	X
admet-929	31	25	7	7	NUM
admet-929	31	26	]	]	PUNCT
admet-929	31	27	.	.	PUNCT
admet-929	32	1	zinc	zinc	NOUN
admet-929	32	2	ions	ion	NOUN
admet-929	32	3	exhibit	exhibit	VERB
admet-929	32	4	anticancer	anticancer	NOUN
admet-929	32	5	and	and	CCONJ
admet-929	32	6	antiviral	antiviral	ADJ
admet-929	32	7	properties	property	NOUN
admet-929	32	8	by	by	ADP
admet-929	32	9	altering	alter	VERB
admet-929	32	10	the	the	DET
admet-929	32	11	lysosome	lysosome	ADJ
admet-929	32	12	membrane	membrane	NOUN
admet-929	32	13	permeability	permeability	NOUN
admet-929	32	14	[	[	X
admet-929	32	15	8	8	NUM
admet-929	32	16	]	]	PUNCT
admet-929	32	17	and	and	CCONJ
admet-929	32	18	the	the	DET
admet-929	32	19	viral	viral	ADJ
admet-929	32	20	rna	rna	NOUN
admet-929	32	21	-	-	PUNCT
admet-929	32	22	dependent	dependent	ADJ
admet-929	32	23	rna	rna	NOUN
admet-929	32	24	polymerase	polymerase	NOUN
admet-929	32	25	enzyme	enzyme	NOUN
admet-929	32	26	and	and	CCONJ
admet-929	32	27	thus	thus	ADV
admet-929	32	28	inhibit	inhibit	VERB
admet-929	32	29	the	the	DET
admet-929	32	30	virus	virus	NOUN
admet-929	32	31	replication	replication	NOUN
admet-929	32	32	process	process	NOUN
admet-929	32	33	inside	inside	ADP
admet-929	32	34	the	the	DET
admet-929	32	35	cells	cell	NOUN
admet-929	32	36	.	.	PUNCT
admet-929	33	1	figure	figure	NOUN
admet-929	33	2	1	1	NUM
admet-929	33	3	shows	show	VERB
admet-929	33	4	the	the	DET
admet-929	33	5	chemical	chemical	NOUN
admet-929	33	6	structures	structure	NOUN
admet-929	33	7	of	of	ADP
admet-929	33	8	cq	cq	NOUN
admet-929	33	9	and	and	CCONJ
admet-929	33	10	hcq	hcq	PROPN
admet-929	33	11	.	.	PUNCT
admet-929	34	1	hcq	hcq	PROPN
admet-929	34	2	has	have	VERB
admet-929	34	3	an	an	DET
admet-929	34	4	additional	additional	ADJ
admet-929	34	5	hydroxyl	hydroxyl	NOUN
admet-929	34	6	group	group	NOUN
admet-929	34	7	that	that	PRON
admet-929	34	8	makes	make	VERB
admet-929	34	9	the	the	DET
admet-929	34	10	molecule	molecule	NOUN
admet-929	34	11	less	less	ADV
admet-929	34	12	lipophilic	lipophilic	ADJ
admet-929	34	13	,	,	PUNCT
admet-929	34	14	reducing	reduce	VERB
admet-929	34	15	the	the	DET
admet-929	34	16	severity	severity	NOUN
admet-929	34	17	of	of	ADP
admet-929	34	18	side	side	NOUN
admet-929	34	19	effects	effect	NOUN
admet-929	34	20	and	and	CCONJ
admet-929	34	21	toxicity	toxicity	NOUN
admet-929	34	22	.	.	PUNCT
admet-929	35	1	chloroquine	chloroquine	NOUN
admet-929	35	2	(	(	PUNCT
admet-929	35	3	cq	cq	NOUN
admet-929	35	4	)	)	PUNCT
admet-929	35	5	hydroxy	hydroxy	PROPN
admet-929	35	6	-	-	PUNCT
admet-929	35	7	chloroquine	chloroquine	NOUN
admet-929	35	8	(	(	PUNCT
admet-929	35	9	hcq	hcq	NOUN
admet-929	35	10	)	)	PUNCT
admet-929	35	11	figure	figure	NOUN
admet-929	35	12	1	1	NUM
admet-929	35	13	.	.	PUNCT
admet-929	36	1	the	the	DET
admet-929	36	2	chemical	chemical	ADJ
admet-929	36	3	structure	structure	NOUN
admet-929	36	4	of	of	ADP
admet-929	36	5	chloroquine	chloroquine	NOUN
admet-929	36	6	(	(	PUNCT
admet-929	36	7	cq	cq	NOUN
admet-929	36	8	)	)	PUNCT
admet-929	36	9	and	and	CCONJ
admet-929	36	10	hydroxy	hydroxy	PROPN
admet-929	36	11	-	-	PUNCT
admet-929	36	12	chloroquine	chloroquine	NOUN
admet-929	36	13	(	(	PUNCT
admet-929	36	14	hcq	hcq	NOUN
admet-929	36	15	)	)	PUNCT
admet-929	36	16	both	both	DET
admet-929	36	17	compounds	compound	NOUN
admet-929	36	18	are	be	AUX
admet-929	36	19	racemic	racemic	ADJ
admet-929	36	20	mixtures	mixture	NOUN
admet-929	36	21	,	,	PUNCT
admet-929	36	22	but	but	CCONJ
admet-929	36	23	it	it	PRON
admet-929	36	24	has	have	AUX
admet-929	36	25	been	be	AUX
admet-929	36	26	observed	observe	VERB
admet-929	36	27	that	that	SCONJ
admet-929	36	28	the	the	DET
admet-929	36	29	enantiomers	enantiomer	NOUN
admet-929	36	30	behave	behave	VERB
admet-929	36	31	differently	differently	ADV
admet-929	36	32	in	in	ADP
admet-929	36	33	vivo	vivo	NOUN
admet-929	36	34	regarding	regard	VERB
admet-929	36	35	their	their	PRON
admet-929	36	36	pharmacokinetics	pharmacokinetic	NOUN
admet-929	37	1	[	[	X
admet-929	37	2	9	9	NUM
admet-929	37	3	]	]	PUNCT
admet-929	37	4	and	and	CCONJ
admet-929	37	5	metabolism	metabolism	NOUN
admet-929	37	6	[	[	X
admet-929	37	7	10	10	NUM
admet-929	37	8	]	]	PUNCT
admet-929	37	9	.	.	PUNCT
admet-929	38	1	it	it	PRON
admet-929	38	2	has	have	AUX
admet-929	38	3	been	be	AUX
admet-929	38	4	reported	report	VERB
admet-929	38	5	that	that	SCONJ
admet-929	38	6	the	the	DET
admet-929	38	7	desethyl	desethyl	PROPN
admet-929	38	8	cq	cq	NOUN
admet-929	38	9	excreted	excrete	VERB
admet-929	38	10	by	by	ADP
admet-929	38	11	men	man	NOUN
admet-929	38	12	after	after	ADP
admet-929	38	13	treatment	treatment	NOUN
admet-929	38	14	with	with	ADP
admet-929	38	15	racemic	racemic	ADJ
admet-929	38	16	cq	cq	PROPN
admet-929	38	17	is	be	AUX
admet-929	38	18	optically	optically	ADV
admet-929	38	19	active	active	ADJ
admet-929	38	20	[	[	X
admet-929	38	21	11	11	NUM
admet-929	38	22	]	]	PUNCT
admet-929	38	23	and	and	CCONJ
admet-929	38	24	that	that	SCONJ
admet-929	38	25	the	the	DET
admet-929	38	26	renal	renal	ADJ
admet-929	38	27	clearance	clearance	NOUN
admet-929	38	28	of	of	ADP
admet-929	38	29	the	the	DET
admet-929	38	30	racemic	racemic	PROPN
admet-929	38	31	cq	cq	PROPN
admet-929	38	32	drug	drug	NOUN
admet-929	38	33	is	be	AUX
admet-929	38	34	a	a	DET
admet-929	38	35	stereoselective	stereoselective	ADJ
admet-929	38	36	process	process	NOUN
admet-929	38	37	[	[	X
admet-929	38	38	9,12,13	9,12,13	NUM
admet-929	38	39	]	]	PUNCT
admet-929	38	40	.	.	PUNCT
admet-929	39	1	in	in	ADP
admet-929	39	2	vitro	vitro	X
admet-929	39	3	efficacy	efficacy	NOUN
admet-929	39	4	studies	study	NOUN
admet-929	39	5	did	do	AUX
admet-929	39	6	not	not	PART
admet-929	39	7	show	show	VERB
admet-929	39	8	any	any	DET
admet-929	39	9	difference	difference	NOUN
admet-929	39	10	between	between	ADP
admet-929	39	11	the	the	DET
admet-929	39	12	efficacy	efficacy	NOUN
admet-929	39	13	of	of	ADP
admet-929	39	14	the	the	DET
admet-929	39	15	enantiomers	enantiomer	NOUN
admet-929	39	16	[	[	X
admet-929	39	17	14	14	NUM
admet-929	39	18	]	]	PUNCT
admet-929	39	19	,	,	PUNCT
admet-929	39	20	but	but	CCONJ
admet-929	39	21	in	in	ADP
admet-929	39	22	vivo	vivo	NOUN
admet-929	39	23	(	(	PUNCT
admet-929	39	24	rat	rat	NOUN
admet-929	39	25	)	)	PUNCT
admet-929	39	26	studies	study	NOUN
admet-929	39	27	have	have	AUX
admet-929	39	28	shown	show	VERB
admet-929	39	29	a	a	DET
admet-929	39	30	greater	great	ADJ
admet-929	39	31	efficacy	efficacy	NOUN
admet-929	39	32	for	for	ADP
admet-929	39	33	the	the	DET
admet-929	39	34	(	(	PUNCT
admet-929	39	35	+	+	NOUN
admet-929	39	36	)	)	PUNCT
admet-929	39	37	-(s)-cq	-(s)-cq	PUNCT
admet-929	39	38	than	than	ADP
admet-929	39	39	the	the	DET
admet-929	39	40	(	(	PUNCT
admet-929	39	41	-)-r	-)-r	ADJ
admet-929	39	42	-	-	PUNCT
admet-929	39	43	enantiomer	enantiomer	NOUN
admet-929	40	1	[	[	X
admet-929	40	2	13,15,16	13,15,16	NUM
admet-929	40	3	]	]	PUNCT
admet-929	40	4	.	.	PUNCT
admet-929	41	1	more	more	ADV
admet-929	41	2	recent	recent	ADJ
admet-929	41	3	article	article	NOUN
admet-929	41	4	[	[	X
admet-929	41	5	17	17	NUM
admet-929	41	6	]	]	PUNCT
admet-929	41	7	suggests	suggest	VERB
admet-929	41	8	chiral	chiral	ADJ
admet-929	41	9	switches	switch	NOUN
admet-929	41	10	of	of	ADP
admet-929	41	11	enantiomers	enantiomer	NOUN
admet-929	41	12	as	as	ADP
admet-929	41	13	more	more	ADV
admet-929	41	14	potent	potent	ADJ
admet-929	41	15	forms	form	NOUN
admet-929	41	16	against	against	ADP
admet-929	41	17	covid-19	covid-19	PROPN
admet-929	41	18	.	.	PUNCT
admet-929	42	1	it	it	PRON
admet-929	42	2	may	may	AUX
admet-929	42	3	be	be	AUX
admet-929	42	4	explained	explain	VERB
admet-929	42	5	by	by	ADP
admet-929	42	6	the	the	DET
admet-929	42	7	stereoselective	stereoselective	ADJ
admet-929	42	8	disposition	disposition	NOUN
admet-929	42	9	of	of	ADP
admet-929	42	10	cq	cq	NOUN
admet-929	42	11	and	and	CCONJ
admet-929	42	12	hcq	hcq	NOUN
admet-929	42	13	in	in	ADP
admet-929	42	14	vivo	vivo	NOUN
admet-929	42	15	.	.	PUNCT
admet-929	43	1	several	several	ADJ
admet-929	43	2	studies	study	NOUN
admet-929	43	3	have	have	AUX
admet-929	43	4	already	already	ADV
admet-929	43	5	been	be	AUX
admet-929	43	6	published	publish	VERB
admet-929	43	7	on	on	ADP
admet-929	43	8	the	the	DET
admet-929	43	9	stereoselective	stereoselective	ADJ
admet-929	43	10	blood	blood	NOUN
admet-929	43	11	and	and	CCONJ
admet-929	43	12	plasma	plasma	NOUN
admet-929	43	13	protein	protein	NOUN
admet-929	43	14	binding	bind	VERB
admet-929	43	15	of	of	ADP
admet-929	43	16	the	the	DET
admet-929	43	17	two	two	NUM
admet-929	43	18	compounds	compound	NOUN
admet-929	43	19	using	use	VERB
admet-929	43	20	pure	pure	ADJ
admet-929	43	21	enantiomers	enantiomer	NOUN
admet-929	43	22	[	[	X
admet-929	43	23	18	18	NUM
admet-929	43	24	-	-	SYM
admet-929	43	25	20	20	NUM
admet-929	43	26	]	]	PUNCT
admet-929	43	27	added	add	VERB
admet-929	43	28	to	to	ADP
admet-929	43	29	plasma	plasma	NOUN
admet-929	43	30	and	and	CCONJ
admet-929	43	31	blood	blood	NOUN
admet-929	43	32	.	.	PUNCT
admet-929	44	1	the	the	DET
admet-929	44	2	application	application	NOUN
admet-929	44	3	of	of	ADP
admet-929	44	4	chemically	chemically	ADV
admet-929	44	5	bonded	bond	VERB
admet-929	44	6	chiral	chiral	ADJ
admet-929	44	7	stationary	stationary	ADJ
admet-929	44	8	phases	phase	NOUN
admet-929	44	9	(	(	PUNCT
admet-929	44	10	chiralpak	chiralpak	PROPN
admet-929	44	11	hsa	hsa	PROPN
admet-929	44	12	and	and	CCONJ
admet-929	44	13	chiralpak	chiralpak	VERB
admet-929	44	14	agp	agp	PROPN
admet-929	44	15	)	)	PUNCT
admet-929	44	16	is	be	AUX
admet-929	44	17	a	a	DET
admet-929	44	18	powerful	powerful	ADJ
admet-929	44	19	tool	tool	NOUN
admet-929	44	20	for	for	ADP
admet-929	44	21	separating	separate	VERB
admet-929	44	22	racemic	racemic	ADJ
admet-929	44	23	mixtures	mixture	NOUN
admet-929	44	24	[	[	X
admet-929	44	25	20	20	NUM
admet-929	44	26	]	]	PUNCT
admet-929	44	27	.	.	PUNCT
admet-929	45	1	it	it	PRON
admet-929	45	2	was	be	AUX
admet-929	45	3	found	find	VERB
admet-929	45	4	that	that	SCONJ
admet-929	45	5	the	the	DET
admet-929	45	6	cq	cq	PROPN
admet-929	45	7	enantiomers	enantiomer	NOUN
admet-929	45	8	differ	differ	VERB
admet-929	45	9	in	in	ADP
admet-929	45	10	their	their	PRON
admet-929	45	11	binding	binding	NOUN
admet-929	45	12	to	to	ADP
admet-929	45	13	plasma	plasma	NOUN
admet-929	45	14	.	.	PUNCT
admet-929	46	1	the	the	DET
admet-929	46	2	(	(	PUNCT
admet-929	46	3	+	+	NOUN
admet-929	46	4	)	)	PUNCT
admet-929	46	5	-(s)-cq	-(s)-cq	PUNCT
admet-929	46	6	has	have	VERB
admet-929	46	7	a	a	DET
admet-929	46	8	higher	high	ADJ
admet-929	46	9	binding	binding	NOUN
admet-929	46	10	to	to	ADP
admet-929	46	11	human	human	ADJ
admet-929	46	12	serum	serum	NOUN
admet-929	46	13	albumin	albumin	PROPN
admet-929	46	14	(	(	PUNCT
admet-929	46	15	hsa	hsa	PROPN
admet-929	46	16	)	)	PUNCT
admet-929	46	17	than	than	ADP
admet-929	46	18	the	the	DET
admet-929	46	19	(	(	PUNCT
admet-929	46	20	-)-(r)enantiomer	-)-(r)enantiomer	NUM
admet-929	46	21	,	,	PUNCT
admet-929	46	22	whereas	whereas	SCONJ
admet-929	46	23	the	the	DET
admet-929	46	24	latter	latter	ADJ
admet-929	46	25	bound	bind	VERB
admet-929	46	26	more	more	ADV
admet-929	46	27	strongly	strongly	ADV
admet-929	46	28	to	to	ADP
admet-929	46	29	α-1	α-1	NOUN
admet-929	46	30	-	-	PUNCT
admet-929	46	31	acid	acid	NOUN
admet-929	46	32	-	-	PUNCT
admet-929	46	33	glycoprotein	glycoprotein	NOUN
admet-929	46	34	(	(	PUNCT
admet-929	46	35	agp	agp	NOUN
admet-929	46	36	)	)	PUNCT
admet-929	46	37	than	than	ADP
admet-929	46	38	the	the	DET
admet-929	46	39	(	(	PUNCT
admet-929	46	40	+	+	NOUN
admet-929	46	41	)	)	PUNCT
admet-929	46	42	-(s)-cq	-(s)-cq	X
admet-929	46	43	.	.	PUNCT
admet-929	47	1	the	the	DET
admet-929	47	2	in	in	ADV
admet-929	47	3	vitro	vitro	X
admet-929	47	4	human	human	ADJ
admet-929	47	5	plasma	plasma	NOUN
admet-929	47	6	protein	protein	NOUN
admet-929	47	7	binding	bind	VERB
admet-929	47	8	of	of	ADP
admet-929	47	9	hcq	hcq	NOUN
admet-929	47	10	was	be	AUX
admet-929	47	11	also	also	ADV
admet-929	47	12	enantioselective	enantioselective	ADJ
admet-929	47	13	:	:	PUNCT
admet-929	47	14	the	the	DET
admet-929	47	15	binding	binding	NOUN
admet-929	47	16	of	of	ADP
admet-929	47	17	(	(	PUNCT
admet-929	47	18	+	+	NOUN
admet-929	47	19	)	)	PUNCT
admet-929	47	20	-(s)-hcq	-(s)-hcq	NOUN
admet-929	47	21	was	be	AUX
admet-929	47	22	almost	almost	ADV
admet-929	47	23	2	2	NUM
admet-929	47	24	-	-	NOUN
admet-929	47	25	fold	fold	VERB
admet-929	47	26	higher	high	ADJ
admet-929	47	27	than	than	ADP
admet-929	47	28	(	(	PUNCT
admet-929	47	29	-)-(r)-hcq	-)-(r)-hcq	NUM
admet-929	47	30	(	(	PUNCT
admet-929	47	31	64	64	NUM
admet-929	47	32	%	%	NOUN
admet-929	47	33	against	against	ADP
admet-929	47	34	37	37	NUM
admet-929	47	35	%	%	NOUN
admet-929	47	36	)	)	PUNCT
admet-929	48	1	[	[	X
admet-929	48	2	21	21	NUM
admet-929	48	3	]	]	PUNCT
admet-929	48	4	.	.	PUNCT
admet-929	49	1	chromatographic	chromatographic	ADJ
admet-929	49	2	separations	separation	NOUN
admet-929	49	3	of	of	ADP
admet-929	49	4	cq	cq	NOUN
admet-929	49	5	and	and	CCONJ
admet-929	49	6	hcq	hcq	NOUN
admet-929	49	7	and	and	CCONJ
admet-929	49	8	their	their	PRON
admet-929	49	9	metabolites	metabolite	NOUN
admet-929	49	10	have	have	AUX
admet-929	49	11	been	be	AUX
admet-929	49	12	reported	report	VERB
admet-929	49	13	using	use	VERB
admet-929	49	14	chiralpak	chiralpak	PROPN
admet-929	49	15	agp	agp	PROPN
admet-929	49	16	and	and	CCONJ
admet-929	49	17	chiralpak	chiralpak	VERB
admet-929	49	18	ad	ad	NOUN
admet-929	49	19	hplc	hplc	NOUN
admet-929	49	20	columns	column	NOUN
admet-929	49	21	[	[	X
admet-929	49	22	18,22	18,22	X
admet-929	49	23	]	]	X
admet-929	49	24	,	,	PUNCT
admet-929	49	25	[	[	X
admet-929	49	26	23	23	NUM
admet-929	49	27	]	]	PUNCT
admet-929	49	28	.	.	PUNCT
admet-929	50	1	other	other	ADJ
admet-929	50	2	chromatographic	chromatographic	ADJ
admet-929	50	3	methods	method	NOUN
admet-929	50	4	have	have	AUX
admet-929	50	5	been	be	AUX
admet-929	50	6	reported	report	VERB
admet-929	50	7	for	for	ADP
admet-929	50	8	analytical	analytical	ADJ
admet-929	50	9	and	and	CCONJ
admet-929	50	10	preparative	preparative	ADJ
admet-929	50	11	separations	separation	NOUN
admet-929	50	12	of	of	ADP
admet-929	50	13	cq	cq	NOUN
admet-929	50	14	and	and	CCONJ
admet-929	50	15	hcq	hcq	NOUN
admet-929	50	16	enantiomers	enantiomer	NOUN
admet-929	50	17	[	[	X
admet-929	50	18	24,25	24,25	NUM
admet-929	50	19	]	]	PUNCT
admet-929	50	20	.	.	PUNCT
admet-929	51	1	biomimetic	biomimetic	ADJ
admet-929	51	2	hplc	hplc	NOUN
admet-929	51	3	properties	property	NOUN
admet-929	51	4	can	can	AUX
admet-929	51	5	be	be	AUX
admet-929	51	6	used	use	VERB
admet-929	51	7	to	to	PART
admet-929	51	8	estimate	estimate	VERB
admet-929	51	9	the	the	DET
admet-929	51	10	in	in	ADP
admet-929	51	11	vivo	vivo	ADJ
admet-929	51	12	distribution	distribution	NOUN
admet-929	51	13	(	(	PUNCT
admet-929	51	14	volume	volume	NOUN
admet-929	51	15	of	of	ADP
admet-929	51	16	distribution	distribution	NOUN
admet-929	51	17	,	,	PUNCT
admet-929	51	18	vd	vd	NOUN
admet-929	51	19	,	,	PUNCT
admet-929	51	20	the	the	DET
admet-929	51	21	unbound	unbound	NOUN
admet-929	51	22	volume	volume	NOUN
admet-929	51	23	of	of	ADP
admet-929	51	24	distribution	distribution	NOUN
admet-929	51	25	,	,	PUNCT
admet-929	51	26	vdu	vdu	PROPN
admet-929	51	27	)	)	PUNCT
admet-929	51	28	,	,	PUNCT
admet-929	51	29	drug	drug	NOUN
admet-929	51	30	efficiency	efficiency	NOUN
admet-929	51	31	and	and	CCONJ
admet-929	51	32	various	various	ADJ
admet-929	51	33	tissue	tissue	NOUN
admet-929	51	34	binding	bind	VERB
admet-929	51	35	properties	property	NOUN
admet-929	51	36	of	of	ADP
admet-929	51	37	admet	admet	PROPN
admet-929	51	38	&	&	CCONJ
admet-929	51	39	dmpk	dmpk	PROPN
admet-929	51	40	9(2	9(2	NUM
admet-929	51	41	)	)	PUNCT
admet-929	51	42	(	(	PUNCT
admet-929	51	43	2021	2021	NUM
admet-929	51	44	)	)	PUNCT
admet-929	51	45	151	151	NUM
admet-929	51	46	-	-	SYM
admet-929	51	47	165	165	NUM
admet-929	51	48	biomimetic	biomimetic	ADJ
admet-929	51	49	properties	property	NOUN
admet-929	51	50	of	of	ADP
admet-929	51	51	chlorquine	chlorquine	NOUN
admet-929	51	52	enantiomers	enantiomer	NOUN
admet-929	51	53	doi	doi	NOUN
admet-929	51	54	:	:	PUNCT
admet-929	51	55	https://doi.org/10.5599/admet.929	https://doi.org/10.5599/admet.929	VERB
admet-929	51	56	153	153	NUM
admet-929	51	57	compounds	compound	NOUN
admet-929	51	58	[	[	PUNCT
admet-929	51	59	26	26	NUM
admet-929	51	60	-	-	SYM
admet-929	51	61	28	28	NUM
admet-929	51	62	]	]	PUNCT
admet-929	51	63	.	.	PUNCT
admet-929	52	1	the	the	DET
admet-929	52	2	hsa	hsa	PROPN
admet-929	52	3	and	and	CCONJ
admet-929	52	4	agp	agp	NOUN
admet-929	52	5	binding	bind	VERB
admet-929	52	6	can	can	AUX
admet-929	52	7	be	be	AUX
admet-929	52	8	measured	measure	VERB
admet-929	52	9	using	use	VERB
admet-929	52	10	chiralpak	chiralpak	PROPN
admet-929	52	11	hsa	hsa	PROPN
admet-929	52	12	and	and	CCONJ
admet-929	52	13	chiralpak	chiralpak	VERB
admet-929	52	14	agp	agp	PROPN
admet-929	52	15	hplc	hplc	NOUN
admet-929	52	16	columns	column	NOUN
admet-929	52	17	(	(	PUNCT
admet-929	52	18	chiral	chiral	ADJ
admet-929	52	19	technologies	technology	NOUN
admet-929	52	20	europe	europe	PROPN
admet-929	52	21	,	,	PUNCT
admet-929	52	22	france	france	PROPN
admet-929	52	23	)	)	PUNCT
admet-929	52	24	.	.	PUNCT
admet-929	53	1	in	in	ADP
admet-929	53	2	this	this	DET
admet-929	53	3	way	way	NOUN
admet-929	53	4	,	,	PUNCT
admet-929	53	5	a	a	DET
admet-929	53	6	different	different	ADJ
admet-929	53	7	estimation	estimation	NOUN
admet-929	53	8	of	of	ADP
admet-929	53	9	the	the	DET
admet-929	53	10	in	in	ADP
admet-929	53	11	vivo	vivo	ADJ
admet-929	53	12	distribution	distribution	NOUN
admet-929	53	13	and	and	CCONJ
admet-929	53	14	tissue	tissue	NOUN
admet-929	53	15	binding	bind	VERB
admet-929	53	16	for	for	ADP
admet-929	53	17	the	the	DET
admet-929	53	18	different	different	ADJ
admet-929	53	19	enantiomers	enantiomer	NOUN
admet-929	53	20	can	can	AUX
admet-929	53	21	be	be	AUX
admet-929	53	22	obtained	obtain	VERB
admet-929	53	23	supposing	suppose	VERB
admet-929	53	24	they	they	PRON
admet-929	53	25	provided	provide	VERB
admet-929	53	26	two	two	NUM
admet-929	53	27	requisite	requisite	ADJ
admet-929	53	28	peaks	peak	NOUN
admet-929	53	29	from	from	ADP
admet-929	53	30	the	the	DET
admet-929	53	31	chromatography	chromatography	NOUN
admet-929	53	32	,	,	PUNCT
admet-929	53	33	enabling	enable	VERB
admet-929	53	34	property	property	NOUN
admet-929	53	35	measurements	measurement	NOUN
admet-929	53	36	.	.	PUNCT
admet-929	54	1	the	the	DET
admet-929	54	2	aim	aim	NOUN
admet-929	54	3	of	of	ADP
admet-929	54	4	this	this	DET
admet-929	54	5	study	study	NOUN
admet-929	54	6	was	be	AUX
admet-929	54	7	to	to	PART
admet-929	54	8	measure	measure	VERB
admet-929	54	9	the	the	DET
admet-929	54	10	biomimetic	biomimetic	ADJ
admet-929	54	11	properties	property	NOUN
admet-929	54	12	of	of	ADP
admet-929	54	13	cq	cq	NOUN
admet-929	54	14	and	and	CCONJ
admet-929	54	15	hcq	hcq	NOUN
admet-929	54	16	with	with	ADP
admet-929	54	17	special	special	ADJ
admet-929	54	18	emphasis	emphasis	NOUN
admet-929	54	19	on	on	ADP
admet-929	54	20	the	the	DET
admet-929	54	21	different	different	ADJ
admet-929	54	22	properties	property	NOUN
admet-929	54	23	of	of	ADP
admet-929	54	24	their	their	PRON
admet-929	54	25	enantiomers	enantiomer	NOUN
admet-929	54	26	.	.	PUNCT
admet-929	55	1	the	the	DET
admet-929	55	2	other	other	ADJ
admet-929	55	3	aim	aim	NOUN
admet-929	55	4	was	be	AUX
admet-929	55	5	to	to	PART
admet-929	55	6	rationalise	rationalise	VERB
admet-929	55	7	the	the	DET
admet-929	55	8	differences	difference	NOUN
admet-929	55	9	in	in	ADP
admet-929	55	10	the	the	DET
admet-929	55	11	in	in	ADJ
admet-929	55	12	vivo	vivo	ADJ
admet-929	55	13	potency	potency	NOUN
admet-929	55	14	of	of	ADP
admet-929	55	15	the	the	DET
admet-929	55	16	enantiomers	enantiomer	NOUN
admet-929	55	17	that	that	PRON
admet-929	55	18	were	be	AUX
admet-929	55	19	not	not	PART
admet-929	55	20	detected	detect	VERB
admet-929	55	21	in	in	ADP
admet-929	55	22	vitro	vitro	X
admet-929	55	23	.	.	PUNCT
admet-929	56	1	a	a	DET
admet-929	56	2	comparison	comparison	NOUN
admet-929	56	3	can	can	AUX
admet-929	56	4	then	then	ADV
admet-929	56	5	be	be	AUX
admet-929	56	6	made	make	VERB
admet-929	56	7	of	of	ADP
admet-929	56	8	the	the	DET
admet-929	56	9	estimated	estimate	VERB
admet-929	56	10	tissue	tissue	NOUN
admet-929	56	11	binding	bind	VERB
admet-929	56	12	and	and	CCONJ
admet-929	56	13	distribution	distribution	NOUN
admet-929	56	14	data	datum	NOUN
admet-929	56	15	with	with	ADP
admet-929	56	16	the	the	DET
admet-929	56	17	published	publish	VERB
admet-929	56	18	in	in	ADP
admet-929	56	19	vivo	vivo	ADJ
admet-929	56	20	distribution	distribution	NOUN
admet-929	56	21	data	datum	NOUN
admet-929	56	22	.	.	PUNCT
admet-929	57	1	the	the	DET
admet-929	57	2	significance	significance	NOUN
admet-929	57	3	of	of	ADP
admet-929	57	4	the	the	DET
admet-929	57	5	differences	difference	NOUN
admet-929	57	6	in	in	ADP
admet-929	57	7	properties	property	NOUN
admet-929	57	8	between	between	ADP
admet-929	57	9	the	the	DET
admet-929	57	10	(	(	PUNCT
admet-929	57	11	r	r	NOUN
admet-929	57	12	)	)	PUNCT
admet-929	57	13	and	and	CCONJ
admet-929	57	14	(	(	PUNCT
admet-929	57	15	s	s	X
admet-929	57	16	)	)	PUNCT
admet-929	57	17	enantiomers	enantiomer	NOUN
admet-929	57	18	can	can	AUX
admet-929	57	19	then	then	ADV
admet-929	57	20	be	be	AUX
admet-929	57	21	evaluated	evaluate	VERB
admet-929	57	22	.	.	PUNCT
admet-929	58	1	experimental	experimental	ADJ
admet-929	58	2	racemic	racemic	PROPN
admet-929	58	3	cq	cq	PROPN
admet-929	58	4	and	and	CCONJ
admet-929	58	5	hcq	hcq	NOUN
admet-929	58	6	of	of	ADP
admet-929	58	7	the	the	DET
admet-929	58	8	highest	high	ADJ
admet-929	58	9	purity	purity	NOUN
admet-929	58	10	were	be	AUX
admet-929	58	11	purchased	purchase	VERB
admet-929	58	12	from	from	ADP
admet-929	58	13	merck	merck	PROPN
admet-929	58	14	(	(	PUNCT
admet-929	58	15	sigma	sigma	PROPN
admet-929	58	16	-	-	PUNCT
admet-929	58	17	aldrich	aldrich	NOUN
admet-929	58	18	)	)	PUNCT
admet-929	58	19	and	and	CCONJ
admet-929	58	20	were	be	AUX
admet-929	58	21	dissolved	dissolve	VERB
admet-929	58	22	in	in	ADP
admet-929	58	23	dmso	dmso	NOUN
admet-929	58	24	at	at	ADP
admet-929	58	25	a	a	DET
admet-929	58	26	1	1	NUM
admet-929	58	27	mm	mm	NOUN
admet-929	58	28	concentration	concentration	NOUN
admet-929	58	29	.	.	PUNCT
admet-929	59	1	the	the	DET
admet-929	59	2	1	1	NUM
admet-929	59	3	mm	mm	NOUN
admet-929	59	4	solutions	solution	NOUN
admet-929	59	5	were	be	AUX
admet-929	59	6	diluted	dilute	VERB
admet-929	59	7	further	far	ADV
admet-929	59	8	to	to	ADP
admet-929	59	9	0.1	0.1	NUM
admet-929	59	10	mm	mm	NOUN
admet-929	59	11	concentration	concentration	NOUN
admet-929	59	12	from	from	ADP
admet-929	59	13	which	which	PRON
admet-929	59	14	10	10	NUM
admet-929	59	15	µl	µl	NOUN
admet-929	59	16	was	be	AUX
admet-929	59	17	injected	inject	VERB
admet-929	59	18	onto	onto	ADP
admet-929	59	19	the	the	DET
admet-929	59	20	different	different	ADJ
admet-929	59	21	hplc	hplc	NOUN
admet-929	59	22	columns	column	NOUN
admet-929	59	23	.	.	PUNCT
admet-929	60	1	an	an	DET
admet-929	60	2	agilent	agilent	PROPN
admet-929	60	3	1100	1100	NUM
admet-929	60	4	series	series	PROPN
admet-929	60	5	hplc	hplc	NOUN
admet-929	60	6	system	system	NOUN
admet-929	60	7	equipped	equip	VERB
admet-929	60	8	with	with	ADP
admet-929	60	9	an	an	DET
admet-929	60	10	autosampler	autosampler	NOUN
admet-929	60	11	and	and	CCONJ
admet-929	60	12	diode	diode	NOUN
admet-929	60	13	array	array	NOUN
admet-929	60	14	detector	detector	NOUN
admet-929	60	15	was	be	AUX
admet-929	60	16	used	use	VERB
admet-929	60	17	for	for	ADP
admet-929	60	18	the	the	DET
admet-929	60	19	measurements	measurement	NOUN
admet-929	60	20	.	.	PUNCT
admet-929	61	1	measurements	measurement	NOUN
admet-929	61	2	of	of	ADP
admet-929	61	3	lipophilicity	lipophilicity	NOUN
admet-929	61	4	at	at	ADP
admet-929	61	5	three	three	NUM
admet-929	61	6	phs	phs	PROPN
admet-929	61	7	gemini	gemini	PROPN
admet-929	61	8	nx	nx	PROPN
admet-929	61	9	c-18(2	c-18(2	PROPN
admet-929	61	10	)	)	PUNCT
admet-929	61	11	5	5	NUM
admet-929	61	12	um	um	INTJ
admet-929	61	13	columns	column	NOUN
admet-929	61	14	with	with	ADP
admet-929	61	15	dimensions	dimension	NOUN
admet-929	61	16	of	of	ADP
admet-929	61	17	3	3	NUM
admet-929	61	18	x	x	SYM
admet-929	61	19	50	50	NUM
admet-929	61	20	mm	mm	NOUN
admet-929	61	21	(	(	PUNCT
admet-929	61	22	phenomenex	phenomenex	ADV
admet-929	61	23	ltd	ltd	PROPN
admet-929	61	24	.	.	PROPN
admet-929	61	25	macclesfield	macclesfield	PROPN
admet-929	61	26	,	,	PUNCT
admet-929	61	27	uk	uk	PROPN
admet-929	61	28	)	)	PUNCT
admet-929	61	29	were	be	AUX
admet-929	61	30	used	use	VERB
admet-929	61	31	for	for	ADP
admet-929	61	32	the	the	DET
admet-929	61	33	determination	determination	NOUN
admet-929	61	34	of	of	ADP
admet-929	61	35	the	the	DET
admet-929	61	36	chromatographic	chromatographic	ADJ
admet-929	61	37	hydrophobicity	hydrophobicity	NOUN
admet-929	61	38	index	index	NOUN
admet-929	61	39	(	(	PUNCT
admet-929	61	40	chi	chi	NOUN
admet-929	61	41	)	)	PUNCT
admet-929	61	42	and	and	CCONJ
admet-929	61	43	the	the	DET
admet-929	61	44	chilogd	chilogd	ADJ
admet-929	61	45	values	value	NOUN
admet-929	61	46	[	[	X
admet-929	61	47	26	26	NUM
admet-929	61	48	]	]	PUNCT
admet-929	61	49	.	.	PUNCT
admet-929	62	1	the	the	DET
admet-929	62	2	flow	flow	NOUN
admet-929	62	3	rate	rate	NOUN
admet-929	62	4	was	be	AUX
admet-929	62	5	1.0	1.0	NUM
admet-929	62	6	ml	ml	NOUN
admet-929	62	7	/	/	SYM
admet-929	62	8	min	min	NOUN
admet-929	62	9	,	,	PUNCT
admet-929	62	10	with	with	ADP
admet-929	62	11	starting	start	VERB
admet-929	62	12	mobile	mobile	ADJ
admet-929	62	13	phases	phase	NOUN
admet-929	62	14	of	of	ADP
admet-929	62	15	0.01	0.01	NUM
admet-929	62	16	m	m	NOUN
admet-929	62	17	formic	formic	ADJ
admet-929	62	18	acid	acid	NOUN
admet-929	62	19	(	(	PUNCT
admet-929	62	20	ph	ph	NOUN
admet-929	62	21	2.6	2.6	NUM
admet-929	62	22	)	)	PUNCT
admet-929	62	23	,	,	PUNCT
admet-929	62	24	50	50	NUM
admet-929	62	25	mm	mm	NOUN
admet-929	62	26	ammonium	ammonium	NOUN
admet-929	62	27	acetate	acetate	NOUN
admet-929	62	28	adjusted	adjust	VERB
admet-929	62	29	to	to	ADP
admet-929	62	30	ph	ph	PROPN
admet-929	62	31	7.4	7.4	NUM
admet-929	62	32	,	,	PUNCT
admet-929	62	33	and	and	CCONJ
admet-929	62	34	50	50	NUM
admet-929	62	35	mm	mm	NOUN
admet-929	62	36	ammonium	ammonium	NOUN
admet-929	62	37	acetate	acetate	NOUN
admet-929	62	38	with	with	ADP
admet-929	62	39	ph	ph	PROPN
admet-929	62	40	adjusted	adjust	VERB
admet-929	62	41	to	to	ADP
admet-929	62	42	10.5	10.5	NUM
admet-929	62	43	to	to	PART
admet-929	62	44	determine	determine	VERB
admet-929	62	45	the	the	DET
admet-929	62	46	lipophilicity	lipophilicity	NOUN
admet-929	62	47	of	of	ADP
admet-929	62	48	the	the	DET
admet-929	62	49	compounds	compound	NOUN
admet-929	62	50	at	at	ADP
admet-929	62	51	acidic	acidic	ADJ
admet-929	62	52	,	,	PUNCT
admet-929	62	53	neutral	neutral	ADJ
admet-929	62	54	and	and	CCONJ
admet-929	62	55	alkaline	alkaline	NOUN
admet-929	62	56	phs	ph	NOUN
admet-929	62	57	,	,	PUNCT
admet-929	62	58	respectively	respectively	ADV
admet-929	62	59	.	.	PUNCT
admet-929	63	1	an	an	DET
admet-929	63	2	acetonitrile	acetonitrile	ADJ
admet-929	63	3	linear	linear	PROPN
admet-929	63	4	gradient	gradient	NOUN
admet-929	63	5	was	be	AUX
admet-929	63	6	used	use	VERB
admet-929	63	7	from	from	ADP
admet-929	63	8	0	0	NUM
admet-929	63	9	to	to	PART
admet-929	63	10	100	100	NUM
admet-929	63	11	%	%	NOUN
admet-929	63	12	.	.	PUNCT
admet-929	64	1	the	the	DET
admet-929	64	2	acetonitrile	acetonitrile	ADJ
admet-929	64	3	concentration	concentration	NOUN
admet-929	64	4	reached	reach	VERB
admet-929	64	5	100	100	NUM
admet-929	64	6	%	%	NOUN
admet-929	64	7	in	in	ADP
admet-929	64	8	3.5	3.5	NUM
admet-929	64	9	min	min	NOUN
admet-929	64	10	.	.	PUNCT
admet-929	65	1	the	the	DET
admet-929	65	2	100	100	NUM
admet-929	65	3	%	%	NOUN
admet-929	65	4	acetonitrile	acetonitrile	ADJ
admet-929	65	5	mobile	mobile	ADJ
admet-929	65	6	phase	phase	NOUN
admet-929	65	7	was	be	AUX
admet-929	65	8	maintained	maintain	VERB
admet-929	65	9	for	for	ADP
admet-929	65	10	an	an	DET
admet-929	65	11	additional	additional	ADJ
admet-929	65	12	1	1	NUM
admet-929	65	13	min	min	NOUN
admet-929	65	14	before	before	SCONJ
admet-929	65	15	it	it	PRON
admet-929	65	16	was	be	AUX
admet-929	65	17	returned	return	VERB
admet-929	65	18	to	to	ADP
admet-929	65	19	0	0	NUM
admet-929	65	20	%	%	NOUN
admet-929	65	21	at	at	ADP
admet-929	65	22	4.7	4.7	NUM
admet-929	65	23	min	min	NOUN
admet-929	65	24	.	.	PUNCT
admet-929	66	1	the	the	DET
admet-929	66	2	cycle	cycle	NOUN
admet-929	66	3	time	time	NOUN
admet-929	66	4	of	of	ADP
admet-929	66	5	the	the	DET
admet-929	66	6	gradient	gradient	NOUN
admet-929	66	7	run	run	NOUN
admet-929	66	8	was	be	AUX
admet-929	66	9	6	6	NUM
admet-929	66	10	min	min	NOUN
admet-929	66	11	,	,	PUNCT
admet-929	66	12	with	with	ADP
admet-929	66	13	an	an	DET
admet-929	66	14	additional	additional	ADJ
admet-929	66	15	equilibration	equilibration	NOUN
admet-929	66	16	time	time	NOUN
admet-929	66	17	of	of	ADP
admet-929	66	18	1	1	NUM
admet-929	66	19	min	min	NOUN
admet-929	66	20	before	before	ADP
admet-929	66	21	the	the	DET
admet-929	66	22	next	next	ADJ
admet-929	66	23	injection	injection	NOUN
admet-929	66	24	.	.	PUNCT
admet-929	67	1	the	the	DET
admet-929	67	2	error	error	NOUN
admet-929	67	3	in	in	ADP
admet-929	67	4	the	the	DET
admet-929	67	5	retention	retention	NOUN
admet-929	67	6	time	time	NOUN
admet-929	67	7	measurements	measurement	NOUN
admet-929	67	8	is	be	AUX
admet-929	67	9	±0.005	±0.005	VERB
admet-929	67	10	min	min	NOUN
admet-929	67	11	in	in	ADP
admet-929	67	12	general	general	ADJ
admet-929	67	13	after	after	ADP
admet-929	67	14	repeated	repeat	VERB
admet-929	67	15	injections	injection	NOUN
admet-929	67	16	.	.	PUNCT
admet-929	68	1	the	the	DET
admet-929	68	2	set	set	NOUN
admet-929	68	3	of	of	ADP
admet-929	68	4	calibration	calibration	NOUN
admet-929	68	5	compounds	compound	NOUN
admet-929	68	6	gave	give	VERB
admet-929	68	7	an	an	DET
admet-929	68	8	excellent	excellent	ADJ
admet-929	68	9	straight	straight	ADJ
admet-929	68	10	line	line	NOUN
admet-929	68	11	when	when	SCONJ
admet-929	68	12	their	their	PRON
admet-929	68	13	retention	retention	NOUN
admet-929	68	14	time	time	NOUN
admet-929	68	15	data	datum	NOUN
admet-929	68	16	was	be	AUX
admet-929	68	17	plotted	plot	VERB
admet-929	68	18	against	against	ADP
admet-929	68	19	the	the	DET
admet-929	68	20	predefined	predefine	VERB
admet-929	68	21	chi	chi	ADJ
admet-929	68	22	values	value	NOUN
admet-929	68	23	listed	list	VERB
admet-929	68	24	in	in	ADP
admet-929	68	25	table	table	NOUN
admet-929	68	26	1	1	NUM
admet-929	68	27	.	.	PUNCT
admet-929	68	28	table	table	NOUN
admet-929	68	29	1	1	NUM
admet-929	68	30	.	.	PUNCT
admet-929	69	1	the	the	DET
admet-929	69	2	chi	chi	ADJ
admet-929	69	3	values	value	NOUN
admet-929	69	4	of	of	ADP
admet-929	69	5	the	the	DET
admet-929	69	6	calibration	calibration	NOUN
admet-929	69	7	set	set	NOUN
admet-929	69	8	of	of	ADP
admet-929	69	9	compounds	compound	NOUN
admet-929	69	10	at	at	ADP
admet-929	69	11	three	three	NUM
admet-929	69	12	phs	ph	NOUN
admet-929	69	13	[	[	X
admet-929	69	14	29	29	NUM
admet-929	69	15	]	]	PUNCT
admet-929	69	16	.	.	PUNCT
admet-929	70	1	these	these	DET
admet-929	70	2	values	value	NOUN
admet-929	70	3	were	be	AUX
admet-929	70	4	obtained	obtain	VERB
admet-929	70	5	by	by	ADP
admet-929	70	6	fitting	fit	VERB
admet-929	70	7	the	the	DET
admet-929	70	8	isocratically	isocratically	ADV
admet-929	70	9	determined	determined	ADJ
admet-929	70	10	chi	chi	ADJ
admet-929	70	11	values	value	NOUN
admet-929	70	12	and	and	CCONJ
admet-929	70	13	the	the	DET
admet-929	70	14	gradient	gradient	ADJ
admet-929	70	15	retention	retention	NOUN
admet-929	70	16	time	time	NOUN
admet-929	70	17	values	value	NOUN
admet-929	70	18	.	.	PUNCT
admet-929	71	1	the	the	DET
admet-929	71	2	standard	standard	ADJ
admet-929	71	3	error	error	NOUN
admet-929	71	4	ranged	range	VERB
admet-929	71	5	from	from	ADP
admet-929	71	6	0.1	0.1	NUM
admet-929	71	7	to	to	PART
admet-929	71	8	0.8	0.8	NUM
admet-929	71	9	chi	chi	ADJ
admet-929	71	10	values	value	NOUN
admet-929	71	11	.	.	PUNCT
admet-929	72	1	the	the	DET
admet-929	72	2	chromatographic	chromatographic	ADJ
admet-929	72	3	hydrophobicity	hydrophobicity	NOUN
admet-929	72	4	index	index	NOUN
admet-929	72	5	(	(	PUNCT
admet-929	72	6	chi	chi	NOUN
admet-929	72	7	)	)	PUNCT
admet-929	72	8	approximates	approximate	VERB
admet-929	72	9	the	the	DET
admet-929	72	10	acetonitrile	acetonitrile	ADJ
admet-929	72	11	concentration	concentration	NOUN
admet-929	72	12	when	when	SCONJ
admet-929	72	13	the	the	DET
admet-929	72	14	compound	compound	NOUN
admet-929	72	15	elutes	elute	NOUN
admet-929	72	16	.	.	PUNCT
admet-929	73	1	it	it	PRON
admet-929	73	2	can	can	AUX
admet-929	73	3	be	be	AUX
admet-929	73	4	converted	convert	VERB
admet-929	73	5	to	to	ADP
admet-929	73	6	the	the	DET
admet-929	73	7	octanol	octanol	NOUN
admet-929	73	8	/	/	SYM
admet-929	73	9	water	water	NOUN
admet-929	73	10	log	log	NOUN
admet-929	73	11	d	d	NOUN
admet-929	73	12	scale	scale	NOUN
admet-929	73	13	using	use	VERB
admet-929	73	14	chilogd	chilogd	ADJ
admet-929	73	15	=	=	SYM
admet-929	73	16	0.0525*chi	0.0525*chi	NUM
admet-929	73	17	-1.467	-1.467	SYM
admet-929	73	18	.	.	PUNCT
admet-929	74	1	compound	compound	NOUN
admet-929	74	2	chi	chi	NOUN
admet-929	74	3	at	at	ADP
admet-929	74	4	ph	ph	PROPN
admet-929	74	5	2.6	2.6	NUM
admet-929	74	6	chi	chi	NOUN
admet-929	74	7	at	at	ADP
admet-929	74	8	ph	ph	PROPN
admet-929	74	9	7.4	7.4	NUM
admet-929	74	10	chi	chi	NOUN
admet-929	74	11	at	at	ADP
admet-929	74	12	ph	ph	PROPN
admet-929	74	13	10.5	10.5	NUM
admet-929	74	14	theophylline	theophylline	NOUN
admet-929	74	15	17.9	17.9	NUM
admet-929	74	16	18.4	18.4	NUM
admet-929	74	17	5.0	5.0	NUM
admet-929	74	18	phenyl	phenyl	NOUN
admet-929	74	19	tetrazole	tetrazole	NOUN
admet-929	74	20	42.2	42.2	NUM
admet-929	74	21	23.6	23.6	NUM
admet-929	74	22	16.0	16.0	NUM
admet-929	74	23	benzimidazole	benzimidazole	NOUN
admet-929	74	24	6.3	6.3	NUM
admet-929	74	25	34.3	34.3	NUM
admet-929	74	26	30.6	30.6	NUM
admet-929	74	27	colchicine	colchicine	NOUN
admet-929	74	28	43.9	43.9	NUM
admet-929	74	29	45.0	45.0	NUM
admet-929	74	30	43.9	43.9	NUM
admet-929	74	31	phenyl	phenyl	NOUN
admet-929	74	32	theophylline	theophylline	NOUN
admet-929	74	33	51.7	51.7	NUM
admet-929	74	34	51.2	51.2	NUM
admet-929	74	35	51.3	51.3	NUM
admet-929	74	36	acetophenone	acetophenone	NOUN
admet-929	74	37	64.1	64.1	NUM
admet-929	74	38	65.1	65.1	NUM
admet-929	74	39	64.1	64.1	NUM
admet-929	74	40	indole	indole	NOUN
admet-929	74	41	72.1	72.1	NUM
admet-929	74	42	71.5	71.5	NUM
admet-929	74	43	72.1	72.1	NUM
admet-929	74	44	propiophenone	propiophenone	NOUN
admet-929	74	45	77.4	77.4	NUM
admet-929	74	46	77.4	77.4	NUM
admet-929	74	47	77.4	77.4	NUM
admet-929	74	48	butyrophenone	butyrophenone	NOUN
admet-929	74	49	87.3	87.3	NUM
admet-929	74	50	87.5	87.5	NUM
admet-929	74	51	87.3	87.3	NUM
admet-929	74	52	valerophenone	valerophenone	NOUN
admet-929	74	53	96.4	96.4	NUM
admet-929	74	54	96.20	96.20	NUM
admet-929	74	55	96.36	96.36	NUM
admet-929	74	56	https://doi.org/10.5599/admet.929	https://doi.org/10.5599/admet.929	NOUN
admet-929	74	57	klara	klara	PROPN
admet-929	74	58	valko	valko	PROPN
admet-929	74	59	and	and	CCONJ
admet-929	74	60	tong	tong	PROPN
admet-929	74	61	zhang	zhang	PROPN
admet-929	74	62	admet	admet	PROPN
admet-929	74	63	&	&	CCONJ
admet-929	74	64	dmpk	dmpk	PROPN
admet-929	74	65	9(2	9(2	NUM
admet-929	74	66	)	)	PUNCT
admet-929	74	67	(	(	PUNCT
admet-929	74	68	2021	2021	NUM
admet-929	74	69	)	)	PUNCT
admet-929	74	70	151	151	NUM
admet-929	74	71	-	-	SYM
admet-929	74	72	165	165	NUM
admet-929	74	73	154	154	NUM
admet-929	74	74	measurements	measurement	NOUN
admet-929	74	75	of	of	ADP
admet-929	74	76	phospholipid	phospholipid	NOUN
admet-929	74	77	-	-	PUNCT
admet-929	74	78	binding	bind	VERB
admet-929	74	79	at	at	ADP
admet-929	74	80	ph	ph	PROPN
admet-929	74	81	7.4	7.4	NUM
admet-929	74	82	using	use	VERB
admet-929	74	83	an	an	DET
admet-929	74	84	immobilized	immobilized	ADJ
admet-929	74	85	artificial	artificial	ADJ
admet-929	74	86	membrane	membrane	NOUN
admet-929	74	87	(	(	PUNCT
admet-929	74	88	iam	iam	PROPN
admet-929	74	89	)	)	PUNCT
admet-929	74	90	column	column	NOUN
admet-929	74	91	the	the	DET
admet-929	74	92	phospholipid	phospholipid	NOUN
admet-929	74	93	-	-	PUNCT
admet-929	74	94	binding	bind	VERB
admet-929	74	95	was	be	AUX
admet-929	74	96	measured	measure	VERB
admet-929	74	97	using	use	VERB
admet-929	74	98	an	an	DET
admet-929	74	99	iam	iam	PROPN
admet-929	74	100	pc.dd2	pc.dd2	PROPN
admet-929	74	101	column	column	NOUN
admet-929	74	102	with	with	ADP
admet-929	74	103	dimensions	dimension	NOUN
admet-929	74	104	of	of	ADP
admet-929	74	105	100	100	NUM
admet-929	74	106	x	x	SYM
admet-929	74	107	4.6	4.6	NUM
admet-929	74	108	mm	mm	INTJ
admet-929	74	109	(	(	PUNCT
admet-929	74	110	regis	regis	PROPN
admet-929	74	111	technologies	technologies	PROPN
admet-929	74	112	inc	inc	PROPN
admet-929	74	113	.	.	PROPN
admet-929	74	114	,	,	PUNCT
admet-929	74	115	morton	morton	PROPN
admet-929	74	116	grove	grove	PROPN
admet-929	74	117	,	,	PUNCT
admet-929	74	118	il	il	PROPN
admet-929	74	119	,	,	PUNCT
admet-929	74	120	usa	usa	PROPN
admet-929	74	121	)	)	PUNCT
admet-929	74	122	.	.	PUNCT
admet-929	75	1	the	the	DET
admet-929	75	2	gradient	gradient	ADJ
admet-929	75	3	retention	retention	NOUN
admet-929	75	4	times	time	NOUN
admet-929	75	5	of	of	ADP
admet-929	75	6	the	the	DET
admet-929	75	7	compounds	compound	NOUN
admet-929	75	8	were	be	AUX
admet-929	75	9	measured	measure	VERB
admet-929	75	10	using	use	VERB
admet-929	75	11	a	a	DET
admet-929	75	12	50	50	NUM
admet-929	75	13	mm	mm	NOUN
admet-929	75	14	ammonium	ammonium	NOUN
admet-929	75	15	acetate	acetate	NOUN
admet-929	75	16	starting	start	VERB
admet-929	75	17	mobile	mobile	ADJ
admet-929	75	18	phase	phase	NOUN
admet-929	75	19	with	with	ADP
admet-929	75	20	the	the	DET
admet-929	75	21	ph	ph	NOUN
admet-929	75	22	adjusted	adjust	VERB
admet-929	75	23	to	to	ADP
admet-929	75	24	7.4	7.4	NUM
admet-929	75	25	.	.	PUNCT
admet-929	76	1	the	the	DET
admet-929	76	2	mobile	mobile	ADJ
admet-929	76	3	phase	phase	NOUN
admet-929	76	4	flow	flow	NOUN
admet-929	76	5	rate	rate	NOUN
admet-929	76	6	was	be	AUX
admet-929	76	7	1.5	1.5	NUM
admet-929	76	8	ml	ml	NOUN
admet-929	76	9	/	/	SYM
admet-929	76	10	min	min	NOUN
admet-929	76	11	.	.	PUNCT
admet-929	77	1	the	the	DET
admet-929	77	2	acetonitrile	acetonitrile	ADJ
admet-929	77	3	gradient	gradient	NOUN
admet-929	77	4	was	be	AUX
admet-929	77	5	applied	apply	VERB
admet-929	77	6	from	from	ADP
admet-929	77	7	0	0	NUM
admet-929	77	8	min	min	NOUN
admet-929	77	9	to	to	ADP
admet-929	77	10	4.75	4.75	NUM
admet-929	77	11	min	min	NOUN
admet-929	77	12	to	to	PART
admet-929	77	13	reach	reach	VERB
admet-929	77	14	90	90	NUM
admet-929	77	15	%	%	NOUN
admet-929	77	16	.	.	PUNCT
admet-929	78	1	the	the	DET
admet-929	78	2	90	90	NUM
admet-929	78	3	%	%	NOUN
admet-929	78	4	acetonitrile	acetonitrile	ADJ
admet-929	78	5	concentration	concentration	NOUN
admet-929	78	6	was	be	AUX
admet-929	78	7	maintained	maintain	VERB
admet-929	78	8	for	for	ADP
admet-929	78	9	an	an	DET
admet-929	78	10	additional	additional	ADJ
admet-929	78	11	0.5	0.5	NUM
admet-929	78	12	min	min	NOUN
admet-929	78	13	(	(	PUNCT
admet-929	78	14	to	to	ADP
admet-929	78	15	5.25	5.25	NUM
admet-929	78	16	min	min	NOUN
admet-929	78	17	)	)	PUNCT
admet-929	78	18	,	,	PUNCT
admet-929	78	19	then	then	ADV
admet-929	78	20	returned	return	VERB
admet-929	78	21	to	to	ADP
admet-929	78	22	0	0	NUM
admet-929	78	23	%	%	NOUN
admet-929	78	24	by	by	ADP
admet-929	78	25	5.5	5.5	NUM
admet-929	78	26	min	min	NOUN
admet-929	78	27	.	.	PUNCT
admet-929	79	1	the	the	DET
admet-929	79	2	cycle	cycle	NOUN
admet-929	79	3	time	time	NOUN
admet-929	79	4	was	be	AUX
admet-929	79	5	6	6	NUM
admet-929	79	6	min	min	NOUN
admet-929	79	7	plus	plus	CCONJ
admet-929	79	8	an	an	DET
admet-929	79	9	additional	additional	ADJ
admet-929	79	10	1	1	NUM
admet-929	79	11	min	min	NOUN
admet-929	79	12	equilibration	equilibration	NOUN
admet-929	79	13	time	time	NOUN
admet-929	79	14	was	be	AUX
admet-929	79	15	applied	apply	VERB
admet-929	79	16	while	while	SCONJ
admet-929	79	17	the	the	DET
admet-929	79	18	injector	injector	NOUN
admet-929	79	19	prepared	prepare	VERB
admet-929	79	20	for	for	ADP
admet-929	79	21	the	the	DET
admet-929	79	22	next	next	ADJ
admet-929	79	23	injection	injection	NOUN
admet-929	79	24	.	.	PUNCT
admet-929	80	1	the	the	DET
admet-929	80	2	gradient	gradient	ADJ
admet-929	80	3	retention	retention	NOUN
admet-929	80	4	times	time	NOUN
admet-929	80	5	were	be	AUX
admet-929	80	6	calibrated	calibrate	VERB
admet-929	80	7	with	with	ADP
admet-929	80	8	the	the	DET
admet-929	80	9	acetophenone	acetophenone	NOUN
admet-929	80	10	homologues	homologue	NOUN
admet-929	80	11	for	for	ADP
admet-929	80	12	which	which	PRON
admet-929	80	13	the	the	DET
admet-929	80	14	chi	chi	PROPN
admet-929	80	15	iam	iam	PROPN
admet-929	80	16	values	value	NOUN
admet-929	80	17	have	have	AUX
admet-929	80	18	been	be	AUX
admet-929	80	19	established	establish	VERB
admet-929	80	20	using	use	VERB
admet-929	80	21	isocratic	isocratic	ADJ
admet-929	80	22	measurements	measurement	NOUN
admet-929	80	23	[	[	X
admet-929	80	24	26	26	NUM
admet-929	80	25	]	]	PUNCT
admet-929	80	26	.	.	PUNCT
admet-929	81	1	the	the	DET
admet-929	81	2	chromatographic	chromatographic	ADJ
admet-929	81	3	hydrophobicity	hydrophobicity	NOUN
admet-929	81	4	index	index	NOUN
admet-929	81	5	on	on	ADP
admet-929	81	6	the	the	DET
admet-929	81	7	iam	iam	PROPN
admet-929	81	8	column	column	NOUN
admet-929	81	9	[	[	X
admet-929	81	10	chi(iam	chi(iam	NOUN
admet-929	81	11	)	)	PUNCT
admet-929	81	12	]	]	PUNCT
admet-929	81	13	approximates	approximate	VERB
admet-929	81	14	to	to	ADP
admet-929	81	15	the	the	DET
admet-929	81	16	acetonitrile	acetonitrile	ADJ
admet-929	81	17	concentration	concentration	NOUN
admet-929	81	18	in	in	ADP
admet-929	81	19	the	the	DET
admet-929	81	20	mobile	mobile	ADJ
admet-929	81	21	phase	phase	NOUN
admet-929	81	22	when	when	SCONJ
admet-929	81	23	the	the	DET
admet-929	81	24	compound	compound	NOUN
admet-929	81	25	elutes	elute	NOUN
admet-929	81	26	.	.	PUNCT
admet-929	82	1	chi(iam	chi(iam	NOUN
admet-929	82	2	)	)	PUNCT
admet-929	83	1	values	value	NOUN
admet-929	83	2	above	above	ADP
admet-929	83	3	45	45	NUM
admet-929	83	4	indicate	indicate	VERB
admet-929	83	5	strong	strong	ADJ
admet-929	83	6	phospholipid	phospholipid	NOUN
admet-929	83	7	binding	bind	VERB
admet-929	83	8	.	.	PUNCT
admet-929	84	1	repeating	repeat	VERB
admet-929	84	2	the	the	DET
admet-929	84	3	retention	retention	NOUN
admet-929	84	4	time	time	NOUN
admet-929	84	5	measurements	measurement	NOUN
admet-929	84	6	provided	provide	VERB
admet-929	84	7	the	the	DET
admet-929	84	8	error	error	NOUN
admet-929	84	9	only	only	ADV
admet-929	84	10	in	in	ADP
admet-929	84	11	the	the	DET
admet-929	84	12	third	third	ADJ
admet-929	84	13	digit	digit	NOUN
admet-929	84	14	of	of	ADP
admet-929	84	15	the	the	DET
admet-929	84	16	minute	minute	NOUN
admet-929	84	17	(	(	PUNCT
admet-929	84	18	±0.005	±0.005	PROPN
admet-929	84	19	)	)	PUNCT
admet-929	84	20	.	.	PUNCT
admet-929	85	1	measurements	measurement	NOUN
admet-929	85	2	of	of	ADP
admet-929	85	3	plasma	plasma	NOUN
admet-929	85	4	protein	protein	NOUN
admet-929	85	5	binding	bind	VERB
admet-929	85	6	using	use	VERB
admet-929	85	7	chiralpak	chiralpak	PROPN
admet-929	85	8	hsa	hsa	PROPN
admet-929	85	9	and	and	CCONJ
admet-929	85	10	agp	agp	PROPN
admet-929	85	11	columns	column	NOUN
admet-929	85	12	the	the	DET
admet-929	85	13	protein	protein	NOUN
admet-929	85	14	binding	bind	VERB
admet-929	85	15	measurements	measurement	NOUN
admet-929	85	16	were	be	AUX
admet-929	85	17	carried	carry	VERB
admet-929	85	18	out	out	ADP
admet-929	85	19	on	on	ADP
admet-929	85	20	chiralpak	chiralpak	PROPN
admet-929	85	21	hsa	hsa	PROPN
admet-929	85	22	and	and	CCONJ
admet-929	85	23	chiralpak	chiralpak	VERB
admet-929	85	24	agp	agp	PROPN
admet-929	85	25	columns	column	NOUN
admet-929	85	26	with	with	ADP
admet-929	85	27	the	the	DET
admet-929	85	28	dimensions	dimension	NOUN
admet-929	85	29	of	of	ADP
admet-929	85	30	3	3	NUM
admet-929	85	31	x	x	SYM
admet-929	85	32	50	50	NUM
admet-929	85	33	mm	mm	NOUN
admet-929	85	34	with	with	ADP
admet-929	85	35	5	5	NUM
admet-929	85	36	um	um	INTJ
admet-929	85	37	particle	particle	NOUN
admet-929	85	38	size	size	NOUN
admet-929	85	39	stationary	stationary	ADJ
admet-929	85	40	phase	phase	NOUN
admet-929	85	41	(	(	PUNCT
admet-929	85	42	chiril	chiril	PROPN
admet-929	85	43	technologies	technologies	PROPN
admet-929	85	44	europe	europe	PROPN
admet-929	85	45	,	,	PUNCT
admet-929	85	46	france	france	PROPN
admet-929	85	47	)	)	PUNCT
admet-929	85	48	.	.	PUNCT
admet-929	86	1	the	the	DET
admet-929	86	2	mobile	mobile	ADJ
admet-929	86	3	phase	phase	NOUN
admet-929	86	4	was	be	AUX
admet-929	86	5	50	50	NUM
admet-929	86	6	mm	mm	NOUN
admet-929	86	7	ammonium	ammonium	NOUN
admet-929	86	8	acetate	acetate	NOUN
admet-929	86	9	adjusted	adjust	VERB
admet-929	86	10	to	to	ADP
admet-929	86	11	ph	ph	PROPN
admet-929	86	12	7.4	7.4	NUM
admet-929	86	13	with	with	ADP
admet-929	86	14	a	a	DET
admet-929	86	15	flow	flow	NOUN
admet-929	86	16	rate	rate	NOUN
admet-929	86	17	of	of	ADP
admet-929	86	18	1.2	1.2	NUM
admet-929	86	19	ml	ml	NOUN
admet-929	86	20	/	/	SYM
admet-929	86	21	min	min	NOUN
admet-929	86	22	.	.	PROPN
admet-929	87	1	the	the	DET
admet-929	87	2	standard	standard	ADJ
admet-929	87	3	isopropanol	isopropanol	NOUN
admet-929	87	4	(	(	PUNCT
admet-929	87	5	ipa	ipa	PROPN
admet-929	87	6	)	)	PUNCT
admet-929	87	7	gradient	gradient	NOUN
admet-929	87	8	up	up	ADP
admet-929	87	9	to	to	PART
admet-929	87	10	35	35	NUM
admet-929	87	11	%	%	NOUN
admet-929	87	12	was	be	AUX
admet-929	87	13	achieved	achieve	VERB
admet-929	87	14	in	in	ADP
admet-929	87	15	3.5	3.5	NUM
admet-929	87	16	min	min	NOUN
admet-929	87	17	and	and	CCONJ
admet-929	87	18	then	then	ADV
admet-929	87	19	maintained	maintain	VERB
admet-929	87	20	for	for	ADP
admet-929	87	21	1	1	NUM
admet-929	87	22	min	min	NOUN
admet-929	87	23	,	,	PUNCT
admet-929	87	24	before	before	ADP
admet-929	87	25	returning	return	VERB
admet-929	87	26	to	to	ADP
admet-929	87	27	0	0	NUM
admet-929	87	28	%	%	NOUN
admet-929	87	29	at	at	ADP
admet-929	87	30	4.7	4.7	NUM
admet-929	87	31	min	min	NOUN
admet-929	87	32	.	.	PUNCT
admet-929	88	1	the	the	DET
admet-929	88	2	cycle	cycle	NOUN
admet-929	88	3	time	time	NOUN
admet-929	88	4	was	be	AUX
admet-929	88	5	6	6	NUM
admet-929	88	6	min	min	NOUN
admet-929	88	7	with	with	ADP
admet-929	88	8	an	an	DET
admet-929	88	9	additional	additional	ADJ
admet-929	88	10	1	1	NUM
admet-929	88	11	min	min	NOUN
admet-929	88	12	re	re	NOUN
admet-929	88	13	-	-	NOUN
admet-929	88	14	equilibration	equilibration	NOUN
admet-929	88	15	time	time	NOUN
admet-929	88	16	.	.	PUNCT
admet-929	89	1	the	the	DET
admet-929	89	2	racemic	racemic	ADJ
admet-929	89	3	warfarin	warfarin	NOUN
admet-929	89	4	showed	show	VERB
admet-929	89	5	separation	separation	NOUN
admet-929	89	6	of	of	ADP
admet-929	89	7	its	its	PRON
admet-929	89	8	enantiomers	enantiomer	NOUN
admet-929	89	9	at	at	ADP
admet-929	89	10	retention	retention	NOUN
admet-929	89	11	times	time	NOUN
admet-929	89	12	of	of	ADP
admet-929	89	13	3.58	3.58	NUM
admet-929	89	14	and	and	CCONJ
admet-929	89	15	3.77	3.77	NUM
admet-929	89	16	mins	min	NOUN
admet-929	89	17	.	.	PUNCT
admet-929	90	1	the	the	DET
admet-929	90	2	reproducibility	reproducibility	NOUN
admet-929	90	3	of	of	ADP
admet-929	90	4	the	the	DET
admet-929	90	5	retention	retention	NOUN
admet-929	90	6	time	time	NOUN
admet-929	90	7	measurements	measurement	NOUN
admet-929	90	8	was	be	AUX
admet-929	90	9	within	within	ADP
admet-929	90	10	±0.01	±0.01	PROPN
admet-929	90	11	min	min	PROPN
admet-929	90	12	.	.	PUNCT
admet-929	91	1	the	the	DET
admet-929	91	2	calibration	calibration	NOUN
admet-929	91	3	set	set	NOUN
admet-929	91	4	of	of	ADP
admet-929	91	5	compounds	compound	NOUN
admet-929	91	6	and	and	CCONJ
admet-929	91	7	their	their	PRON
admet-929	91	8	literature	literature	NOUN
admet-929	91	9	%	%	NOUN
admet-929	91	10	binding	bind	VERB
admet-929	91	11	data	datum	NOUN
admet-929	91	12	that	that	PRON
admet-929	91	13	were	be	AUX
admet-929	91	14	also	also	ADV
admet-929	91	15	converted	convert	VERB
admet-929	91	16	to	to	PART
admet-929	91	17	log	log	VERB
admet-929	91	18	k	k	PROPN
admet-929	91	19	data	datum	NOUN
admet-929	91	20	are	be	AUX
admet-929	91	21	shown	show	VERB
admet-929	91	22	in	in	ADP
admet-929	91	23	table	table	NOUN
admet-929	91	24	2	2	NUM
admet-929	91	25	.	.	PUNCT
admet-929	92	1	the	the	DET
admet-929	92	2	racemic	racemic	PROPN
admet-929	92	3	cq	cq	PROPN
admet-929	92	4	and	and	CCONJ
admet-929	92	5	hcq	hcq	PROPN
admet-929	92	6	,	,	PUNCT
admet-929	92	7	however	however	ADV
admet-929	92	8	,	,	PUNCT
admet-929	92	9	did	do	AUX
admet-929	92	10	not	not	PART
admet-929	92	11	show	show	VERB
admet-929	92	12	a	a	DET
admet-929	92	13	separation	separation	NOUN
admet-929	92	14	of	of	ADP
admet-929	92	15	their	their	PRON
admet-929	92	16	enantiomers	enantiomer	NOUN
admet-929	92	17	under	under	ADP
admet-929	92	18	such	such	ADJ
admet-929	92	19	chromatographic	chromatographic	ADJ
admet-929	92	20	conditions	condition	NOUN
admet-929	92	21	and	and	CCONJ
admet-929	92	22	therefore	therefore	ADV
admet-929	92	23	,	,	PUNCT
admet-929	92	24	other	other	ADJ
admet-929	92	25	gradients	gradient	NOUN
admet-929	92	26	and	and	CCONJ
admet-929	92	27	isocratic	isocratic	ADJ
admet-929	92	28	mobile	mobile	ADJ
admet-929	92	29	phases	phase	NOUN
admet-929	92	30	were	be	AUX
admet-929	92	31	tested	test	VERB
admet-929	92	32	.	.	PUNCT
admet-929	93	1	figures	figure	NOUN
admet-929	93	2	2a	2a	NUM
admet-929	93	3	and	and	CCONJ
admet-929	93	4	figure	figure	VERB
admet-929	93	5	2b	2b	NOUN
admet-929	93	6	show	show	VERB
admet-929	93	7	the	the	DET
admet-929	93	8	calibration	calibration	NOUN
admet-929	93	9	lines	line	NOUN
admet-929	93	10	obtained	obtain	VERB
admet-929	93	11	for	for	ADP
admet-929	93	12	the	the	DET
admet-929	93	13	hsa	hsa	PROPN
admet-929	93	14	and	and	CCONJ
admet-929	93	15	agp	agp	NOUN
admet-929	93	16	binding	binding	NOUN
admet-929	93	17	,	,	PUNCT
admet-929	93	18	respectively	respectively	ADV
admet-929	93	19	.	.	PUNCT
admet-929	94	1	the	the	DET
admet-929	94	2	8	8	NUM
admet-929	94	3	min	min	NOUN
admet-929	94	4	,	,	PUNCT
admet-929	94	5	“	"	PUNCT
admet-929	94	6	slow	slow	ADJ
admet-929	94	7	gradient	gradient	NOUN
admet-929	94	8	”	"	PUNCT
admet-929	94	9	method	method	NOUN
admet-929	94	10	on	on	ADP
admet-929	94	11	the	the	DET
admet-929	94	12	chiral	chiral	ADJ
admet-929	94	13	hsa	hsa	NOUN
admet-929	94	14	and	and	CCONJ
admet-929	94	15	agp	agp	PROPN
admet-929	94	16	columns	column	NOUN
admet-929	94	17	to	to	PART
admet-929	94	18	be	be	AUX
admet-929	94	19	able	able	ADJ
admet-929	94	20	to	to	PART
admet-929	94	21	separate	separate	VERB
admet-929	94	22	the	the	DET
admet-929	94	23	cq	cq	NOUN
admet-929	94	24	and	and	CCONJ
admet-929	94	25	hcq	hcq	NOUN
admet-929	94	26	enantiomers	enantiomer	NOUN
admet-929	94	27	,	,	PUNCT
admet-929	94	28	the	the	DET
admet-929	94	29	ipa	ipa	PROPN
admet-929	94	30	gradient	gradient	NOUN
admet-929	94	31	was	be	AUX
admet-929	94	32	modified	modify	VERB
admet-929	94	33	.	.	PUNCT
admet-929	95	1	from	from	ADP
admet-929	95	2	0	0	NUM
admet-929	95	3	to	to	PART
admet-929	95	4	4	4	NUM
admet-929	95	5	min	min	NOUN
admet-929	95	6	,	,	PUNCT
admet-929	95	7	the	the	DET
admet-929	95	8	ipa	ipa	PROPN
admet-929	95	9	concentration	concentration	NOUN
admet-929	95	10	was	be	AUX
admet-929	95	11	raised	raise	VERB
admet-929	95	12	from	from	ADP
admet-929	95	13	0	0	NUM
admet-929	95	14	to	to	ADP
admet-929	95	15	15	15	NUM
admet-929	95	16	%	%	NOUN
admet-929	95	17	,	,	PUNCT
admet-929	95	18	and	and	CCONJ
admet-929	95	19	from	from	ADP
admet-929	95	20	4	4	NUM
admet-929	95	21	to	to	PART
admet-929	95	22	5	5	NUM
admet-929	95	23	min	min	NOUN
admet-929	95	24	the	the	DET
admet-929	95	25	15	15	NUM
admet-929	95	26	%	%	NOUN
admet-929	95	27	ipa	ipa	PROPN
admet-929	95	28	was	be	AUX
admet-929	95	29	kept	keep	VERB
admet-929	95	30	constant	constant	ADJ
admet-929	95	31	before	before	SCONJ
admet-929	95	32	it	it	PRON
admet-929	95	33	was	be	AUX
admet-929	95	34	reduced	reduce	VERB
admet-929	95	35	to	to	ADP
admet-929	95	36	0	0	NUM
admet-929	95	37	%	%	NOUN
admet-929	95	38	at	at	ADP
admet-929	95	39	5.2	5.2	NUM
admet-929	95	40	min	min	NOUN
admet-929	95	41	.	.	PUNCT
admet-929	96	1	the	the	DET
admet-929	96	2	cycle	cycle	NOUN
admet-929	96	3	time	time	NOUN
admet-929	96	4	was	be	AUX
admet-929	96	5	8	8	NUM
admet-929	96	6	min	min	NOUN
admet-929	96	7	plus	plus	CCONJ
admet-929	96	8	an	an	DET
admet-929	96	9	additional	additional	ADJ
admet-929	96	10	1	1	NUM
admet-929	96	11	min	min	NOUN
admet-929	96	12	re	re	NOUN
admet-929	96	13	-	-	NOUN
admet-929	96	14	equilibration	equilibration	NOUN
admet-929	96	15	time	time	NOUN
admet-929	96	16	.	.	PUNCT
admet-929	97	1	the	the	DET
admet-929	97	2	same	same	ADJ
admet-929	97	3	compounds	compound	NOUN
admet-929	97	4	and	and	CCONJ
admet-929	97	5	data	datum	NOUN
admet-929	97	6	that	that	PRON
admet-929	97	7	are	be	AUX
admet-929	97	8	listed	list	VERB
admet-929	97	9	in	in	ADP
admet-929	97	10	table	table	NOUN
admet-929	97	11	2	2	NUM
admet-929	97	12	were	be	AUX
admet-929	97	13	used	use	VERB
admet-929	97	14	to	to	PART
admet-929	97	15	calibrate	calibrate	VERB
admet-929	97	16	the	the	DET
admet-929	97	17	retention	retention	NOUN
admet-929	97	18	times	time	NOUN
admet-929	97	19	;	;	PUNCT
admet-929	97	20	however	however	ADV
admet-929	97	21	,	,	PUNCT
admet-929	97	22	warfarin	warfarin	NOUN
admet-929	97	23	,	,	PUNCT
admet-929	97	24	diclofenac	diclofenac	NOUN
admet-929	97	25	and	and	CCONJ
admet-929	97	26	isopropanol	isopropanol	NOUN
admet-929	97	27	could	could	AUX
admet-929	97	28	not	not	PART
admet-929	97	29	be	be	AUX
admet-929	97	30	eluted	elute	VERB
admet-929	97	31	under	under	ADP
admet-929	97	32	this	this	DET
admet-929	97	33	condition	condition	NOUN
admet-929	97	34	.	.	PUNCT
admet-929	98	1	table	table	NOUN
admet-929	98	2	2	2	NUM
admet-929	98	3	.	.	PUNCT
admet-929	99	1	the	the	DET
admet-929	99	2	protein	protein	NOUN
admet-929	99	3	binding	bind	VERB
admet-929	99	4	data	datum	NOUN
admet-929	99	5	of	of	ADP
admet-929	99	6	marketed	market	VERB
admet-929	99	7	drug	drug	NOUN
admet-929	99	8	molecules	molecule	NOUN
admet-929	99	9	that	that	PRON
admet-929	99	10	were	be	AUX
admet-929	99	11	used	use	VERB
admet-929	99	12	to	to	PART
admet-929	99	13	calibrate	calibrate	VERB
admet-929	99	14	the	the	DET
admet-929	99	15	retention	retention	NOUN
admet-929	99	16	times	time	NOUN
admet-929	99	17	obtained	obtain	VERB
admet-929	99	18	on	on	ADP
admet-929	99	19	the	the	DET
admet-929	99	20	chiral	chiral	ADJ
admet-929	99	21	protein	protein	NOUN
admet-929	99	22	columns	column	NOUN
admet-929	99	23	(	(	PUNCT
admet-929	99	24	chiralpak	chiralpak	PROPN
admet-929	99	25	hsa	hsa	PROPN
admet-929	99	26	and	and	CCONJ
admet-929	99	27	chiralpak	chiralpak	VERB
admet-929	99	28	agp	agp	PROPN
admet-929	99	29	)	)	PUNCT
admet-929	99	30	.	.	PUNCT
admet-929	100	1	the	the	DET
admet-929	100	2	%	%	NOUN
admet-929	100	3	binding	bind	VERB
admet-929	100	4	data	datum	NOUN
admet-929	100	5	obtained	obtain	VERB
admet-929	100	6	by	by	ADP
admet-929	100	7	equilibrium	equilibrium	NOUN
admet-929	100	8	dialysis	dialysis	NOUN
admet-929	100	9	were	be	AUX
admet-929	100	10	converted	convert	VERB
admet-929	100	11	to	to	PART
admet-929	100	12	log	log	VERB
admet-929	100	13	k	k	PROPN
admet-929	100	14	data	datum	NOUN
admet-929	100	15	using	use	VERB
admet-929	100	16	log	log	NOUN
admet-929	101	1	k	k	PROPN
admet-929	101	2	=	=	PUNCT
admet-929	101	3	log	log	NOUN
admet-929	101	4	(	(	PUNCT
admet-929	101	5	%	%	INTJ
admet-929	101	6	binding/(101-%binding	binding/(101-%binding	NOUN
admet-929	101	7	)	)	PUNCT
admet-929	101	8	.	.	PUNCT
admet-929	102	1	compound	compound	NOUN
admet-929	102	2	name	name	NOUN
admet-929	102	3	%	%	INTJ
admet-929	102	4	hsa	hsa	INTJ
admet-929	102	5	log	log	NOUN
admet-929	102	6	k	k	PROPN
admet-929	102	7	(	(	PUNCT
admet-929	102	8	hsa	hsa	PROPN
admet-929	102	9	)	)	PUNCT
admet-929	102	10	retention	retention	NOUN
admet-929	102	11	times	time	NOUN
admet-929	102	12	hsa	hsa	PROPN
admet-929	102	13	(	(	PUNCT
admet-929	102	14	tr	tr	VERB
admet-929	102	15	)	)	PUNCT
admet-929	102	16	%	%	NOUN
admet-929	102	17	agp	agp	PROPN
admet-929	102	18	log	log	PROPN
admet-929	102	19	k	k	PROPN
admet-929	102	20	(	(	PUNCT
admet-929	102	21	agp	agp	NOUN
admet-929	102	22	)	)	PUNCT
admet-929	102	23	retention	retention	NOUN
admet-929	102	24	times	time	NOUN
admet-929	102	25	agp	agp	PROPN
admet-929	102	26	(	(	PUNCT
admet-929	102	27	tr	tr	NOUN
admet-929	102	28	)	)	PUNCT
admet-929	102	29	warfarin	warfarin	NOUN
admet-929	102	30	97.9	97.9	NUM
admet-929	102	31	1.5	1.5	NUM
admet-929	102	32	3.6	3.6	NUM
admet-929	102	33	83.2	83.2	NUM
admet-929	102	34	0.7	0.7	NUM
admet-929	102	35	2.6	2.6	NUM
admet-929	102	36	paracetamol	paracetamol	NOUN
admet-929	102	37	14.0	14.0	NUM
admet-929	102	38	-0.8	-0.8	NUM
admet-929	102	39	0.4	0.4	NUM
admet-929	102	40	3.2	3.2	NUM
admet-929	102	41	-1.5	-1.5	SYM
admet-929	102	42	0.3	0.3	NUM
admet-929	102	43	nizatidine	nizatidine	NOUN
admet-929	102	44	20.4	20.4	NUM
admet-929	102	45	-0.6	-0.6	X
admet-929	102	46	0.5	0.5	NUM
admet-929	102	47	37.1	37.1	NUM
admet-929	102	48	-0.2	-0.2	NUM
admet-929	102	49	1.3	1.3	NUM
admet-929	102	50	trimethoprim	trimethoprim	NOUN
admet-929	102	51	37.6	37.6	NUM
admet-929	102	52	-0.2	-0.2	NUM
admet-929	102	53	1.0	1.0	NUM
admet-929	102	54	46.2	46.2	NUM
admet-929	102	55	-0.1	-0.1	PROPN
admet-929	102	56	1.5	1.5	NUM
admet-929	102	57	propranolol	propranolol	NOUN
admet-929	102	58	66.6	66.6	NUM
admet-929	102	59	0.3	0.3	NUM
admet-929	102	60	1.4	1.4	NUM
admet-929	102	61	86	86	NUM
admet-929	102	62	0.8	0.8	NUM
admet-929	102	63	2.8	2.8	NUM
admet-929	102	64	carbamazepine	carbamazepine	NOUN
admet-929	102	65	75.0	75.0	NUM
admet-929	102	66	0.5	0.5	NUM
admet-929	102	67	1.6	1.6	NUM
admet-929	102	68	65	65	NUM
admet-929	102	69	0.3	0.3	NUM
admet-929	102	70	2.1	2.1	NUM
admet-929	102	71	nicardipine	nicardipine	NOUN
admet-929	102	72	95.0	95.0	NUM
admet-929	102	73	1.2	1.2	NUM
admet-929	102	74	2.9	2.9	NUM
admet-929	102	75	87	87	NUM
admet-929	102	76	0.8	0.8	NUM
admet-929	102	77	2.9	2.9	NUM
admet-929	102	78	indomethacin	indomethacin	VERB
admet-929	102	79	99.5	99.5	NUM
admet-929	102	80	1.8	1.8	NUM
admet-929	102	81	4.5	4.5	NUM
admet-929	102	82	56	56	NUM
admet-929	102	83	0.1	0.1	NUM
admet-929	102	84	1.8	1.8	NUM
admet-929	102	85	diclofenac	diclofenac	NOUN
admet-929	102	86	99.8	99.8	NUM
admet-929	102	87	1.9	1.9	NUM
admet-929	102	88	4.3	4.3	NUM
admet-929	102	89	60	60	NUM
admet-929	102	90	0.2	0.2	NUM
admet-929	102	91	1.9	1.9	NUM
admet-929	102	92	admet	admet	X
admet-929	102	93	&	&	CCONJ
admet-929	102	94	dmpk	dmpk	PROPN
admet-929	102	95	9(2	9(2	NUM
admet-929	102	96	)	)	PUNCT
admet-929	102	97	(	(	PUNCT
admet-929	102	98	2021	2021	NUM
admet-929	102	99	)	)	PUNCT
admet-929	102	100	151	151	NUM
admet-929	102	101	-	-	SYM
admet-929	102	102	165	165	NUM
admet-929	102	103	biomimetic	biomimetic	ADJ
admet-929	102	104	properties	property	NOUN
admet-929	102	105	of	of	ADP
admet-929	102	106	chlorquine	chlorquine	NOUN
admet-929	102	107	enantiomers	enantiomer	NOUN
admet-929	102	108	doi	doi	NOUN
admet-929	102	109	:	:	PUNCT
admet-929	102	110	https://doi.org/10.5599/admet.929	https://doi.org/10.5599/admet.929	NOUN
admet-929	102	111	155	155	NUM
admet-929	102	112	figure	figure	NOUN
admet-929	102	113	2	2	NUM
admet-929	102	114	.	.	PUNCT
admet-929	103	1	the	the	DET
admet-929	103	2	calibration	calibration	NOUN
admet-929	103	3	line	line	NOUN
admet-929	103	4	obtained	obtain	VERB
admet-929	103	5	on	on	ADP
admet-929	103	6	the	the	DET
admet-929	103	7	chiralpak	chiralpak	NOUN
admet-929	103	8	hsa	hsa	PROPN
admet-929	103	9	(	(	PUNCT
admet-929	103	10	a	a	NOUN
admet-929	103	11	)	)	PUNCT
admet-929	103	12	and	and	CCONJ
admet-929	103	13	chiralpak	chiralpak	VERB
admet-929	103	14	agp	agp	PROPN
admet-929	103	15	(	(	PUNCT
admet-929	103	16	b	b	NOUN
admet-929	103	17	)	)	PUNCT
admet-929	103	18	columns	column	NOUN
admet-929	103	19	by	by	ADP
admet-929	103	20	plotting	plot	VERB
admet-929	103	21	the	the	DET
admet-929	103	22	logarithmic	logarithmic	ADJ
admet-929	103	23	value	value	NOUN
admet-929	103	24	of	of	ADP
admet-929	103	25	the	the	DET
admet-929	103	26	obtained	obtain	VERB
admet-929	103	27	retention	retention	NOUN
admet-929	103	28	times	time	NOUN
admet-929	103	29	and	and	CCONJ
admet-929	103	30	the	the	DET
admet-929	103	31	log	log	NOUN
admet-929	103	32	k	k	PROPN
admet-929	103	33	values	value	NOUN
admet-929	103	34	derived	derive	VERB
admet-929	103	35	from	from	ADP
admet-929	103	36	the	the	DET
admet-929	103	37	literature	literature	NOUN
admet-929	103	38	%	%	NOUN
admet-929	103	39	binding	bind	VERB
admet-929	103	40	data	datum	NOUN
admet-929	103	41	[	[	X
admet-929	103	42	30,31	30,31	NUM
admet-929	103	43	]	]	X
admet-929	103	44	isocratic	isocratic	ADJ
admet-929	103	45	measurements	measurement	NOUN
admet-929	103	46	of	of	ADP
admet-929	103	47	cq	cq	NOUN
admet-929	103	48	and	and	CCONJ
admet-929	103	49	hq	hq	PROPN
admet-929	103	50	on	on	ADP
admet-929	103	51	chiralpak	chiralpak	PROPN
admet-929	103	52	hsa	hsa	PROPN
admet-929	103	53	column	column	NOUN
admet-929	103	54	as	as	ADP
admet-929	103	55	the	the	DET
admet-929	103	56	cq	cq	NOUN
admet-929	103	57	and	and	CCONJ
admet-929	103	58	hcq	hcq	NOUN
admet-929	103	59	enantiomers	enantiomer	NOUN
admet-929	103	60	were	be	AUX
admet-929	103	61	not	not	PART
admet-929	103	62	separated	separate	VERB
admet-929	103	63	using	use	VERB
admet-929	103	64	the	the	DET
admet-929	103	65	longer	long	ADJ
admet-929	103	66	ipa	ipa	PROPN
admet-929	103	67	gradient	gradient	NOUN
admet-929	103	68	,	,	PUNCT
admet-929	103	69	isocratic	isocratic	ADJ
admet-929	103	70	analyses	analysis	NOUN
admet-929	103	71	were	be	AUX
admet-929	103	72	also	also	ADV
admet-929	103	73	carried	carry	VERB
admet-929	103	74	out	out	ADP
admet-929	103	75	using	use	VERB
admet-929	103	76	a	a	DET
admet-929	103	77	1.2	1.2	NUM
admet-929	103	78	ml	ml	NOUN
admet-929	103	79	/	/	SYM
admet-929	103	80	min	min	NOUN
admet-929	103	81	flow	flow	NOUN
admet-929	103	82	rate	rate	NOUN
admet-929	103	83	with	with	ADP
admet-929	103	84	5	5	NUM
admet-929	103	85	,	,	PUNCT
admet-929	103	86	8	8	NUM
admet-929	103	87	and	and	CCONJ
admet-929	103	88	10	10	NUM
admet-929	103	89	%	%	NOUN
admet-929	103	90	ipa	ipa	PROPN
admet-929	103	91	,	,	PUNCT
admet-929	103	92	respectively	respectively	ADV
admet-929	103	93	.	.	PUNCT
admet-929	104	1	using	use	VERB
admet-929	104	2	5	5	NUM
admet-929	104	3	%	%	NOUN
admet-929	104	4	ipa	ipa	NOUN
admet-929	104	5	in	in	ADP
admet-929	104	6	the	the	DET
admet-929	104	7	mobile	mobile	ADJ
admet-929	104	8	phase	phase	NOUN
admet-929	104	9	,	,	PUNCT
admet-929	104	10	only	only	ADV
admet-929	104	11	paracetamol	paracetamol	NOUN
admet-929	104	12	and	and	CCONJ
admet-929	104	13	propranolol	propranolol	NOUN
admet-929	104	14	eluted	elute	VERB
admet-929	104	15	from	from	ADP
admet-929	104	16	the	the	DET
admet-929	104	17	calibration	calibration	NOUN
admet-929	104	18	set	set	NOUN
admet-929	104	19	of	of	ADP
admet-929	104	20	compounds	compound	NOUN
admet-929	104	21	.	.	PUNCT
admet-929	105	1	when	when	SCONJ
admet-929	105	2	10	10	NUM
admet-929	105	3	%	%	NOUN
admet-929	105	4	ipa	ipa	PROPN
admet-929	105	5	was	be	AUX
admet-929	105	6	used	use	VERB
admet-929	105	7	warfarin	warfarin	NOUN
admet-929	105	8	,	,	PUNCT
admet-929	105	9	propranolol	propranolol	NOUN
admet-929	105	10	and	and	CCONJ
admet-929	105	11	nicardipine	nicardipine	NOUN
admet-929	105	12	were	be	AUX
admet-929	105	13	eluted	elute	VERB
admet-929	105	14	and	and	CCONJ
admet-929	105	15	their	their	PRON
admet-929	105	16	respective	respective	ADJ
admet-929	105	17	retention	retention	NOUN
admet-929	105	18	times	time	NOUN
admet-929	105	19	were	be	AUX
admet-929	105	20	used	use	VERB
admet-929	105	21	to	to	PART
admet-929	105	22	create	create	VERB
admet-929	105	23	a	a	DET
admet-929	105	24	calibration	calibration	NOUN
admet-929	105	25	curve	curve	NOUN
admet-929	105	26	for	for	ADP
admet-929	105	27	the	the	DET
admet-929	105	28	calculation	calculation	NOUN
admet-929	105	29	of	of	ADP
admet-929	105	30	the	the	DET
admet-929	105	31	binding	binding	NOUN
admet-929	105	32	of	of	ADP
admet-929	105	33	cq	cq	PROPN
admet-929	105	34	and	and	CCONJ
admet-929	105	35	hcq	hcq	NOUN
admet-929	105	36	from	from	ADP
admet-929	105	37	their	their	PRON
admet-929	105	38	obtained	obtain	VERB
admet-929	105	39	retention	retention	NOUN
admet-929	105	40	times	time	NOUN
admet-929	105	41	using	use	VERB
admet-929	105	42	the	the	DET
admet-929	105	43	same	same	ADJ
admet-929	105	44	hplc	hplc	NOUN
admet-929	105	45	conditions	condition	NOUN
admet-929	105	46	.	.	PUNCT
admet-929	106	1	measurements	measurement	NOUN
admet-929	106	2	of	of	ADP
admet-929	106	3	human	human	ADJ
admet-929	106	4	plasma	plasma	NOUN
admet-929	106	5	protein	protein	NOUN
admet-929	106	6	binding	bind	VERB
admet-929	106	7	by	by	ADP
admet-929	106	8	rapid	rapid	ADJ
admet-929	106	9	equilibrium	equilibrium	NOUN
admet-929	106	10	dialysis	dialysis	NOUN
admet-929	106	11	(	(	PUNCT
admet-929	106	12	red	red	PROPN
admet-929	106	13	)	)	PUNCT
admet-929	106	14	the	the	DET
admet-929	106	15	test	test	NOUN
admet-929	106	16	compounds	compound	NOUN
admet-929	106	17	were	be	AUX
admet-929	106	18	prepared	prepare	VERB
admet-929	106	19	in	in	ADP
admet-929	106	20	100	100	NUM
admet-929	106	21	%	%	NOUN
admet-929	106	22	pooled	pool	VERB
admet-929	106	23	human	human	ADJ
admet-929	106	24	plasma	plasma	NOUN
admet-929	106	25	.	.	PUNCT
admet-929	107	1	the	the	DET
admet-929	107	2	measurement	measurement	NOUN
admet-929	107	3	was	be	AUX
admet-929	107	4	performed	perform	VERB
admet-929	107	5	using	use	VERB
admet-929	107	6	equilibrium	equilibrium	NOUN
admet-929	107	7	dialysis	dialysis	NOUN
admet-929	107	8	with	with	ADP
admet-929	107	9	the	the	DET
admet-929	107	10	two	two	NUM
admet-929	107	11	compartments	compartment	NOUN
admet-929	107	12	separated	separate	VERB
admet-929	107	13	by	by	ADP
admet-929	107	14	a	a	DET
admet-929	107	15	semi	semi	ADJ
admet-929	107	16	-	-	ADJ
admet-929	107	17	permeable	permeable	ADJ
admet-929	107	18	membrane	membrane	NOUN
admet-929	107	19	.	.	PUNCT
admet-929	108	1	the	the	DET
admet-929	108	2	plasma	plasma	NOUN
admet-929	108	3	solution	solution	NOUN
admet-929	108	4	was	be	AUX
admet-929	108	5	added	add	VERB
admet-929	108	6	to	to	ADP
admet-929	108	7	one	one	NUM
admet-929	108	8	side	side	NOUN
admet-929	108	9	of	of	ADP
admet-929	108	10	the	the	DET
admet-929	108	11	membrane	membrane	NOUN
admet-929	108	12	while	while	SCONJ
admet-929	108	13	buffer	buffer	NOUN
admet-929	108	14	(	(	PUNCT
admet-929	108	15	ph	ph	NOUN
admet-929	108	16	7.4	7.4	NUM
admet-929	108	17	)	)	PUNCT
admet-929	108	18	was	be	AUX
admet-929	108	19	added	add	VERB
admet-929	108	20	to	to	ADP
admet-929	108	21	the	the	DET
admet-929	108	22	other	other	ADJ
admet-929	108	23	side	side	NOUN
admet-929	108	24	.	.	PUNCT
admet-929	109	1	the	the	DET
admet-929	109	2	system	system	NOUN
admet-929	109	3	was	be	AUX
admet-929	109	4	allowed	allow	VERB
admet-929	109	5	to	to	PART
admet-929	109	6	reach	reach	VERB
admet-929	109	7	equilibrium	equilibrium	NOUN
admet-929	109	8	at	at	ADP
admet-929	109	9	37	37	NUM
admet-929	109	10	°	°	NOUN
admet-929	109	11	c	c	NOUN
admet-929	109	12	.	.	PUNCT
admet-929	110	1	compound	compound	NOUN
admet-929	110	2	concentration	concentration	NOUN
admet-929	110	3	on	on	ADP
admet-929	110	4	both	both	DET
admet-929	110	5	sides	side	NOUN
admet-929	110	6	of	of	ADP
admet-929	110	7	the	the	DET
admet-929	110	8	membrane	membrane	NOUN
admet-929	110	9	was	be	AUX
admet-929	110	10	measured	measure	VERB
admet-929	110	11	by	by	ADP
admet-929	110	12	lc	lc	PROPN
admet-929	110	13	-	-	PUNCT
admet-929	110	14	ms	ms	PROPN
admet-929	110	15	/	/	SYM
admet-929	110	16	ms	ms	PROPN
admet-929	110	17	,	,	PUNCT
admet-929	110	18	and	and	CCONJ
admet-929	110	19	the	the	DET
admet-929	110	20	fraction	fraction	NOUN
admet-929	110	21	of	of	ADP
admet-929	110	22	unbound	unbound	NOUN
admet-929	110	23	compound	compound	NOUN
admet-929	110	24	calculated	calculate	VERB
admet-929	110	25	.	.	PUNCT
admet-929	111	1	calibration	calibration	NOUN
admet-929	111	2	standards	standard	NOUN
admet-929	111	3	were	be	AUX
admet-929	111	4	prepared	prepare	VERB
admet-929	111	5	in	in	ADP
admet-929	111	6	plasma	plasma	NOUN
admet-929	111	7	and	and	CCONJ
admet-929	111	8	buffer	buffer	NOUN
admet-929	111	9	.	.	PUNCT
admet-929	112	1	test	test	NOUN
admet-929	112	2	compound	compound	NOUN
admet-929	112	3	incubations	incubation	NOUN
admet-929	112	4	were	be	AUX
admet-929	112	5	performed	perform	VERB
admet-929	112	6	in	in	ADP
admet-929	112	7	triplicate	triplicate	NOUN
admet-929	112	8	.	.	PUNCT
admet-929	113	1	a	a	DET
admet-929	113	2	control	control	NOUN
admet-929	113	3	compound	compound	NOUN
admet-929	113	4	was	be	AUX
admet-929	113	5	included	include	VERB
admet-929	113	6	in	in	ADP
admet-929	113	7	each	each	DET
admet-929	113	8	experiment	experiment	NOUN
admet-929	113	9	.	.	PUNCT
admet-929	114	1	the	the	DET
admet-929	114	2	solutions	solution	NOUN
admet-929	114	3	for	for	ADP
admet-929	114	4	each	each	DET
admet-929	114	5	batch	batch	NOUN
admet-929	114	6	of	of	ADP
admet-929	114	7	compounds	compound	NOUN
admet-929	114	8	were	be	AUX
admet-929	114	9	combined	combine	VERB
admet-929	114	10	into	into	ADP
admet-929	114	11	two	two	NUM
admet-929	114	12	groups	group	NOUN
admet-929	114	13	(	(	PUNCT
admet-929	114	14	protein	protein	NOUN
admet-929	114	15	-	-	PUNCT
admet-929	114	16	free	free	ADJ
admet-929	114	17	and	and	CCONJ
admet-929	114	18	protein	protein	NOUN
admet-929	114	19	-	-	PUNCT
admet-929	114	20	containing	contain	VERB
admet-929	114	21	)	)	PUNCT
admet-929	114	22	.	.	PUNCT
admet-929	115	1	cassette	cassette	NOUN
admet-929	115	2	analysed	analyse	VERB
admet-929	115	3	by	by	ADP
admet-929	115	4	lc	lc	PROPN
admet-929	115	5	-	-	PUNCT
admet-929	115	6	ms	ms	PROPN
admet-929	115	7	/	/	PROPN
admet-929	115	8	ms	ms	NOUN
admet-929	115	9	using	use	VERB
admet-929	115	10	two	two	NUM
admet-929	115	11	sets	set	NOUN
admet-929	115	12	of	of	ADP
admet-929	115	13	calibration	calibration	NOUN
admet-929	115	14	standards	standard	NOUN
admet-929	115	15	for	for	ADP
admet-929	115	16	protein	protein	NOUN
admet-929	115	17	-	-	PUNCT
admet-929	115	18	free	free	ADJ
admet-929	115	19	solutions	solution	NOUN
admet-929	115	20	(	(	PUNCT
admet-929	115	21	7	7	NUM
admet-929	115	22	points	point	NOUN
admet-929	115	23	)	)	PUNCT
admet-929	115	24	and	and	CCONJ
admet-929	115	25	protein	protein	NOUN
admet-929	115	26	-	-	PUNCT
admet-929	115	27	containing	contain	VERB
admet-929	115	28	solutions	solution	NOUN
admet-929	115	29	(	(	PUNCT
admet-929	115	30	7	7	NUM
admet-929	115	31	points	point	NOUN
admet-929	115	32	)	)	PUNCT
admet-929	115	33	.	.	PUNCT
admet-929	116	1	the	the	DET
admet-929	116	2	experiments	experiment	NOUN
admet-929	116	3	were	be	AUX
admet-929	116	4	carried	carry	VERB
admet-929	116	5	out	out	ADP
admet-929	116	6	at	at	ADP
admet-929	116	7	cyprotex	cyprotex	PROPN
admet-929	116	8	discovery	discovery	PROPN
admet-929	116	9	ltd	ltd	PROPN
admet-929	116	10	(	(	PUNCT
admet-929	116	11	uk	uk	PROPN
admet-929	116	12	)	)	PUNCT
admet-929	116	13	and	and	CCONJ
admet-929	116	14	repeated	repeat	VERB
admet-929	116	15	at	at	ADP
admet-929	116	16	sygnature	sygnature	PROPN
admet-929	116	17	discovery	discovery	PROPN
admet-929	116	18	ltd	ltd	PROPN
admet-929	116	19	(	(	PUNCT
admet-929	116	20	uk	uk	PROPN
admet-929	116	21	)	)	PUNCT
admet-929	116	22	laboratories	laboratory	NOUN
admet-929	116	23	using	use	VERB
admet-929	116	24	their	their	PRON
admet-929	116	25	generic	generic	ADJ
admet-929	116	26	lc	lc	PROPN
admet-929	116	27	/	/	SYM
admet-929	116	28	ms	ms	PROPN
admet-929	116	29	method	method	NOUN
admet-929	116	30	.	.	PUNCT
admet-929	117	1	the	the	DET
admet-929	117	2	unbound	unbound	NOUN
admet-929	117	3	fraction	fraction	NOUN
admet-929	117	4	(	(	PUNCT
admet-929	117	5	fu	fu	NOUN
admet-929	117	6	)	)	PUNCT
admet-929	117	7	is	be	AUX
admet-929	117	8	calculated	calculate	VERB
admet-929	117	9	from	from	ADP
admet-929	117	10	the	the	DET
admet-929	117	11	concentration	concentration	NOUN
admet-929	117	12	of	of	ADP
admet-929	117	13	the	the	DET
admet-929	117	14	test	test	NOUN
admet-929	117	15	compound	compound	NOUN
admet-929	117	16	in	in	ADP
admet-929	117	17	the	the	DET
admet-929	117	18	protein	protein	NOUN
admet-929	117	19	-	-	PUNCT
admet-929	117	20	containing	contain	VERB
admet-929	117	21	side	side	NOUN
admet-929	117	22	cp	cp	NOUN
admet-929	117	23	and	and	CCONJ
admet-929	117	24	the	the	DET
admet-929	117	25	protein	protein	NOUN
admet-929	117	26	-	-	PUNCT
admet-929	117	27	free	free	ADJ
admet-929	117	28	side	side	NOUN
admet-929	117	29	cf	cf	NOUN
admet-929	117	30	based	base	VERB
admet-929	117	31	on	on	ADP
admet-929	117	32	the	the	DET
admet-929	117	33	formula	formula	NOUN
admet-929	117	34	:	:	PUNCT
admet-929	117	35	fu=	fu=	NOUN
admet-929	117	36	1	1	NUM
admet-929	117	37	–	–	PUNCT
admet-929	117	38	(	(	PUNCT
admet-929	117	39	cp	cp	VERB
admet-929	117	40	-	-	ADJ
admet-929	117	41	cf)/cp	cf)/cp	ADJ
admet-929	117	42	.	.	PUNCT
admet-929	118	1	results	result	NOUN
admet-929	118	2	and	and	CCONJ
admet-929	118	3	discussion	discussion	VERB
admet-929	118	4	the	the	DET
admet-929	118	5	lipophilicity	lipophilicity	NOUN
admet-929	118	6	of	of	ADP
admet-929	118	7	compounds	compound	NOUN
admet-929	118	8	is	be	AUX
admet-929	118	9	an	an	DET
admet-929	118	10	important	important	ADJ
admet-929	118	11	physicochemical	physicochemical	ADJ
admet-929	118	12	property	property	NOUN
admet-929	118	13	that	that	PRON
admet-929	118	14	may	may	AUX
admet-929	118	15	explain	explain	VERB
admet-929	118	16	the	the	DET
admet-929	118	17	protein	protein	NOUN
admet-929	118	18	binding	bind	VERB
admet-929	118	19	,	,	PUNCT
admet-929	118	20	the	the	DET
admet-929	118	21	volume	volume	NOUN
admet-929	118	22	of	of	ADP
admet-929	118	23	distribution	distribution	NOUN
admet-929	118	24	and	and	CCONJ
admet-929	118	25	other	other	ADJ
admet-929	118	26	distribution	distribution	NOUN
admet-929	118	27	properties	property	NOUN
admet-929	118	28	of	of	ADP
admet-929	118	29	drug	drug	NOUN
admet-929	118	30	molecules	molecule	NOUN
admet-929	118	31	.	.	PUNCT
admet-929	119	1	it	it	PRON
admet-929	119	2	is	be	AUX
admet-929	119	3	usually	usually	ADV
admet-929	119	4	characterised	characterise	VERB
admet-929	119	5	by	by	ADP
admet-929	119	6	octanol	octanol	NOUN
admet-929	119	7	/	/	SYM
admet-929	119	8	water	water	NOUN
admet-929	119	9	partition	partition	NOUN
admet-929	119	10	(	(	PUNCT
admet-929	119	11	log	log	VERB
admet-929	119	12	p	p	X
admet-929	119	13	)	)	PUNCT
admet-929	119	14	and	and	CCONJ
admet-929	119	15	distribution	distribution	NOUN
admet-929	119	16	(	(	PUNCT
admet-929	119	17	log	log	NOUN
admet-929	119	18	d	d	NOUN
admet-929	119	19	)	)	PUNCT
admet-929	119	20	coefficients	coefficient	NOUN
admet-929	119	21	.	.	PUNCT
admet-929	120	1	the	the	DET
admet-929	120	2	log	log	NOUN
admet-929	120	3	p	p	NOUN
admet-929	120	4	refers	refer	VERB
admet-929	120	5	to	to	ADP
admet-929	120	6	the	the	DET
admet-929	120	7	neutral	neutral	ADJ
admet-929	120	8	form	form	NOUN
admet-929	120	9	of	of	ADP
admet-929	120	10	the	the	DET
admet-929	120	11	molecule	molecule	NOUN
admet-929	120	12	,	,	PUNCT
admet-929	120	13	while	while	SCONJ
admet-929	120	14	log	log	NOUN
admet-929	120	15	d	d	PROPN
admet-929	120	16	refers	refer	VERB
admet-929	120	17	to	to	ADP
admet-929	120	18	the	the	DET
admet-929	120	19	compound	compound	NOUN
admet-929	120	20	’s	’s	PART
admet-929	120	21	distribution	distribution	NOUN
admet-929	120	22	between	between	ADP
admet-929	120	23	octanol	octanol	NOUN
admet-929	120	24	and	and	CCONJ
admet-929	120	25	water	water	NOUN
admet-929	120	26	at	at	ADP
admet-929	120	27	physiological	physiological	ADJ
admet-929	120	28	ph	ph	NOUN
admet-929	120	29	(	(	PUNCT
admet-929	120	30	ph	ph	NOUN
admet-929	120	31	7.4	7.4	NUM
admet-929	120	32	)	)	PUNCT
admet-929	120	33	.	.	PUNCT
admet-929	121	1	the	the	DET
admet-929	121	2	calculated	calculate	VERB
admet-929	121	3	and	and	CCONJ
admet-929	121	4	measured	measure	VERB
admet-929	121	5	physicochemical	physicochemical	ADJ
admet-929	121	6	properties	property	NOUN
admet-929	121	7	of	of	ADP
admet-929	121	8	cq	cq	NOUN
admet-929	121	9	and	and	CCONJ
admet-929	121	10	hcq	hcq	NOUN
admet-929	121	11	are	be	AUX
admet-929	121	12	listed	list	VERB
admet-929	121	13	in	in	ADP
admet-929	121	14	table	table	NOUN
admet-929	121	15	3	3	NUM
admet-929	121	16	.	.	PUNCT
admet-929	122	1	(	(	PUNCT
admet-929	122	2	a	a	X
admet-929	122	3	)	)	PUNCT
admet-929	122	4	(	(	PUNCT
admet-929	122	5	b	b	X
admet-929	122	6	)	)	PUNCT
admet-929	122	7	https://doi.org/10.5599/admet.929	https://doi.org/10.5599/admet.929	NOUN
admet-929	122	8	klara	klara	PROPN
admet-929	122	9	valko	valko	PROPN
admet-929	122	10	and	and	CCONJ
admet-929	122	11	tong	tong	PROPN
admet-929	122	12	zhang	zhang	PROPN
admet-929	122	13	admet	admet	PROPN
admet-929	122	14	&	&	CCONJ
admet-929	122	15	dmpk	dmpk	PROPN
admet-929	122	16	9(2	9(2	NUM
admet-929	122	17	)	)	PUNCT
admet-929	122	18	(	(	PUNCT
admet-929	122	19	2021	2021	NUM
admet-929	122	20	)	)	PUNCT
admet-929	122	21	151	151	NUM
admet-929	122	22	-	-	SYM
admet-929	122	23	165	165	NUM
admet-929	122	24	156	156	NUM
admet-929	122	25	table	table	NOUN
admet-929	123	1	3	3	NUM
admet-929	123	2	.	.	X
admet-929	123	3	literature	literature	NOUN
admet-929	123	4	and	and	CCONJ
admet-929	123	5	calculated	calculate	VERB
admet-929	123	6	data	datum	NOUN
admet-929	123	7	for	for	ADP
admet-929	123	8	cq	cq	NOUN
admet-929	123	9	and	and	CCONJ
admet-929	123	10	hcq	hcq	NOUN
admet-929	123	11	it	it	PRON
admet-929	123	12	can	can	AUX
admet-929	123	13	be	be	AUX
admet-929	123	14	seen	see	VERB
admet-929	123	15	in	in	ADP
admet-929	123	16	table	table	NOUN
admet-929	123	17	3	3	NUM
admet-929	123	18	that	that	PRON
admet-929	123	19	the	the	DET
admet-929	123	20	measured	measure	VERB
admet-929	123	21	and	and	CCONJ
admet-929	123	22	calculated	calculate	VERB
admet-929	123	23	lipophilicity	lipophilicity	NOUN
admet-929	123	24	values	value	NOUN
admet-929	123	25	vary	vary	VERB
admet-929	123	26	a	a	DET
admet-929	123	27	lot	lot	NOUN
admet-929	123	28	.	.	PUNCT
admet-929	124	1	in	in	ADP
admet-929	124	2	almost	almost	ADV
admet-929	124	3	all	all	PRON
admet-929	124	4	cases	case	NOUN
admet-929	124	5	,	,	PUNCT
admet-929	124	6	hcq	hcq	PROPN
admet-929	124	7	is	be	AUX
admet-929	124	8	less	less	ADV
admet-929	124	9	lipophilic	lipophilic	ADJ
admet-929	124	10	due	due	ADP
admet-929	124	11	to	to	ADP
admet-929	124	12	the	the	DET
admet-929	124	13	hydrophilic	hydrophilic	ADJ
admet-929	124	14	hydroxy	hydroxy	PROPN
admet-929	124	15	group	group	NOUN
admet-929	124	16	that	that	PRON
admet-929	124	17	also	also	ADV
admet-929	124	18	affects	affect	VERB
admet-929	124	19	the	the	DET
admet-929	124	20	basicity	basicity	NOUN
admet-929	124	21	of	of	ADP
admet-929	124	22	this	this	DET
admet-929	124	23	compound	compound	NOUN
admet-929	124	24	.	.	PUNCT
admet-929	125	1	comparing	compare	VERB
admet-929	125	2	the	the	DET
admet-929	125	3	log	log	NOUN
admet-929	125	4	d	d	NOUN
admet-929	125	5	and	and	CCONJ
admet-929	125	6	log	log	VERB
admet-929	125	7	p	p	NOUN
admet-929	125	8	values	value	NOUN
admet-929	125	9	,	,	PUNCT
admet-929	125	10	it	it	PRON
admet-929	125	11	is	be	AUX
admet-929	125	12	apparent	apparent	ADJ
admet-929	125	13	that	that	SCONJ
admet-929	125	14	a	a	DET
admet-929	125	15	high	high	ADJ
admet-929	125	16	percentage	percentage	NOUN
admet-929	125	17	of	of	ADP
admet-929	125	18	both	both	DET
admet-929	125	19	molecules	molecule	NOUN
admet-929	125	20	are	be	AUX
admet-929	125	21	ionised	ionise	VERB
admet-929	125	22	(	(	PUNCT
admet-929	125	23	positively	positively	ADV
admet-929	125	24	charged	charge	VERB
admet-929	125	25	)	)	PUNCT
admet-929	125	26	at	at	ADP
admet-929	125	27	ph	ph	PROPN
admet-929	125	28	7.4	7.4	NUM
admet-929	125	29	.	.	PUNCT
admet-929	126	1	the	the	DET
admet-929	126	2	measured	measure	VERB
admet-929	126	3	chi	chi	PROPN
admet-929	126	4	log	log	NOUN
admet-929	126	5	p	p	NOUN
admet-929	126	6	may	may	AUX
admet-929	126	7	well	well	ADV
admet-929	126	8	be	be	AUX
admet-929	126	9	underestimating	underestimate	VERB
admet-929	126	10	the	the	DET
admet-929	126	11	lipophilicity	lipophilicity	NOUN
admet-929	126	12	as	as	SCONJ
admet-929	126	13	the	the	DET
admet-929	126	14	pka	pka	PROPN
admet-929	126	15	values	value	NOUN
admet-929	126	16	are	be	AUX
admet-929	126	17	around	around	ADP
admet-929	126	18	10	10	NUM
admet-929	126	19	.	.	PUNCT
admet-929	127	1	therefore	therefore	ADV
admet-929	127	2	,	,	PUNCT
admet-929	127	3	the	the	DET
admet-929	127	4	mobile	mobile	ADJ
admet-929	127	5	phase	phase	NOUN
admet-929	127	6	applied	apply	VERB
admet-929	127	7	ph	ph	ADJ
admet-929	127	8	10.5	10.5	NUM
admet-929	127	9	may	may	AUX
admet-929	127	10	not	not	PART
admet-929	127	11	suppress	suppress	VERB
admet-929	127	12	the	the	DET
admet-929	127	13	ionisation	ionisation	NOUN
admet-929	127	14	of	of	ADP
admet-929	127	15	both	both	DET
admet-929	127	16	molecules	molecule	NOUN
admet-929	127	17	completely	completely	ADV
admet-929	127	18	,	,	PUNCT
admet-929	127	19	and	and	CCONJ
admet-929	127	20	the	the	DET
admet-929	127	21	actual	actual	ADJ
admet-929	127	22	lipophilicity	lipophilicity	NOUN
admet-929	127	23	of	of	ADP
admet-929	127	24	the	the	DET
admet-929	127	25	neutral	neutral	ADJ
admet-929	127	26	form	form	NOUN
admet-929	127	27	of	of	ADP
admet-929	127	28	these	these	DET
admet-929	127	29	molecules	molecule	NOUN
admet-929	127	30	can	can	AUX
admet-929	127	31	be	be	AUX
admet-929	127	32	much	much	ADV
admet-929	127	33	greater	great	ADJ
admet-929	127	34	.	.	PUNCT
admet-929	128	1	table	table	NOUN
admet-929	128	2	4	4	NUM
admet-929	128	3	shows	show	VERB
admet-929	128	4	the	the	DET
admet-929	128	5	measured	measured	ADJ
admet-929	128	6	phospholipid	phospholipid	NOUN
admet-929	128	7	and	and	CCONJ
admet-929	128	8	protein	protein	NOUN
admet-929	128	9	binding	bind	VERB
admet-929	128	10	data	datum	NOUN
admet-929	128	11	of	of	ADP
admet-929	128	12	the	the	DET
admet-929	128	13	two	two	NUM
admet-929	128	14	compounds	compound	NOUN
admet-929	128	15	obtained	obtain	VERB
admet-929	128	16	using	use	VERB
admet-929	128	17	the	the	DET
admet-929	128	18	standard	standard	ADJ
admet-929	128	19	6	6	NUM
admet-929	128	20	min	min	NOUN
admet-929	128	21	protocol	protocol	NOUN
admet-929	129	1	[	[	X
admet-929	129	2	26	26	NUM
admet-929	129	3	]	]	PUNCT
admet-929	129	4	.	.	PUNCT
admet-929	130	1	it	it	PRON
admet-929	130	2	can	can	AUX
admet-929	130	3	be	be	AUX
admet-929	130	4	seen	see	VERB
admet-929	130	5	from	from	ADP
admet-929	130	6	table	table	NOUN
admet-929	130	7	4	4	NUM
admet-929	130	8	that	that	PRON
admet-929	130	9	hcq	hcq	NOUN
admet-929	130	10	has	have	VERB
admet-929	130	11	marginally	marginally	ADV
admet-929	130	12	weaker	weak	ADJ
admet-929	130	13	binding	bind	VERB
admet-929	130	14	to	to	ADP
admet-929	130	15	phospholipids	phospholipid	NOUN
admet-929	130	16	and	and	CCONJ
admet-929	130	17	plasma	plasma	NOUN
admet-929	130	18	proteins	protein	NOUN
admet-929	130	19	.	.	PUNCT
admet-929	131	1	the	the	DET
admet-929	131	2	enantiomers	enantiomer	NOUN
admet-929	131	3	could	could	AUX
admet-929	131	4	not	not	PART
admet-929	131	5	be	be	AUX
admet-929	131	6	separated	separate	VERB
admet-929	131	7	on	on	ADP
admet-929	131	8	the	the	DET
admet-929	131	9	chiral	chiral	ADJ
admet-929	131	10	hsa	hsa	NOUN
admet-929	131	11	and	and	CCONJ
admet-929	131	12	agp	agp	NOUN
admet-929	131	13	stationary	stationary	ADJ
admet-929	131	14	phases	phase	NOUN
admet-929	131	15	using	use	VERB
admet-929	131	16	the	the	DET
admet-929	131	17	standard	standard	ADJ
admet-929	131	18	high	high	ADJ
admet-929	131	19	-	-	PUNCT
admet-929	131	20	throughput	throughput	NOUN
admet-929	131	21	protocol	protocol	NOUN
admet-929	131	22	for	for	ADP
admet-929	131	23	biomimetic	biomimetic	ADJ
admet-929	131	24	property	property	NOUN
admet-929	131	25	measurements	measurement	NOUN
admet-929	131	26	.	.	PUNCT
admet-929	132	1	the	the	DET
admet-929	132	2	phospholipid	phospholipid	NOUN
admet-929	132	3	-	-	PUNCT
admet-929	132	4	binding	bind	VERB
admet-929	132	5	is	be	AUX
admet-929	132	6	in	in	ADP
admet-929	132	7	a	a	DET
admet-929	132	8	medium	medium	ADJ
admet-929	132	9	-	-	PUNCT
admet-929	132	10	strong	strong	ADJ
admet-929	132	11	range	range	NOUN
admet-929	132	12	.	.	PUNCT
admet-929	133	1	it	it	PRON
admet-929	133	2	has	have	AUX
admet-929	133	3	been	be	AUX
admet-929	133	4	reported	report	VERB
admet-929	133	5	that	that	SCONJ
admet-929	133	6	compounds	compound	VERB
admet-929	133	7	that	that	PRON
admet-929	133	8	have	have	VERB
admet-929	133	9	chi	chi	PROPN
admet-929	133	10	iam	iam	PROPN
admet-929	133	11	values	value	VERB
admet-929	133	12	greater	great	ADJ
admet-929	133	13	than	than	ADP
admet-929	133	14	50	50	NUM
admet-929	133	15	have	have	VERB
admet-929	133	16	the	the	DET
admet-929	133	17	potential	potential	NOUN
admet-929	133	18	for	for	ADP
admet-929	133	19	promiscuous	promiscuous	ADJ
admet-929	133	20	binding	bind	VERB
admet-929	133	21	and	and	CCONJ
admet-929	133	22	causing	cause	VERB
admet-929	133	23	phospholipidosis	phospholipidosis	NOUN
admet-929	133	24	[	[	X
admet-929	133	25	34	34	NUM
admet-929	133	26	]	]	PUNCT
admet-929	133	27	.	.	PUNCT
admet-929	134	1	the	the	DET
admet-929	134	2	herg	herg	PROPN
admet-929	134	3	inhibition	inhibition	NOUN
admet-929	134	4	,	,	PUNCT
admet-929	134	5	which	which	PRON
admet-929	134	6	is	be	AUX
admet-929	134	7	an	an	DET
admet-929	134	8	indicator	indicator	NOUN
admet-929	134	9	for	for	ADP
admet-929	134	10	causing	cause	VERB
admet-929	134	11	arrhythmia	arrhythmia	NOUN
admet-929	134	12	and	and	CCONJ
admet-929	134	13	heart	heart	NOUN
admet-929	134	14	condition	condition	NOUN
admet-929	134	15	,	,	PUNCT
admet-929	134	16	is	be	AUX
admet-929	134	17	also	also	ADV
admet-929	134	18	associated	associate	VERB
admet-929	134	19	with	with	ADP
admet-929	134	20	lipophilic	lipophilic	ADJ
admet-929	134	21	and	and	CCONJ
admet-929	134	22	positively	positively	ADV
admet-929	134	23	charged	charge	VERB
admet-929	134	24	compounds	compound	NOUN
admet-929	134	25	[	[	X
admet-929	134	26	35	35	NUM
admet-929	134	27	]	]	PUNCT
admet-929	134	28	.	.	PUNCT
admet-929	135	1	positively	positively	ADV
admet-929	135	2	charged	charge	VERB
admet-929	135	3	compounds	compound	NOUN
admet-929	135	4	usually	usually	ADV
admet-929	135	5	have	have	VERB
admet-929	135	6	stronger	strong	ADJ
admet-929	135	7	binding	binding	NOUN
admet-929	135	8	to	to	ADP
admet-929	135	9	iam	iam	PROPN
admet-929	135	10	than	than	ADP
admet-929	135	11	isolipophilic	isolipophilic	ADJ
admet-929	135	12	compounds	compound	NOUN
admet-929	135	13	without	without	ADP
admet-929	135	14	the	the	DET
admet-929	135	15	presence	presence	NOUN
admet-929	135	16	of	of	ADP
admet-929	135	17	positive	positive	ADJ
admet-929	135	18	charge	charge	NOUN
admet-929	135	19	[	[	X
admet-929	135	20	36	36	NUM
admet-929	135	21	]	]	PUNCT
admet-929	135	22	.	.	PUNCT
admet-929	136	1	however	however	ADV
admet-929	136	2	,	,	PUNCT
admet-929	136	3	the	the	DET
admet-929	136	4	chi	chi	PROPN
admet-929	136	5	iam	iam	PROPN
admet-929	136	6	values	value	NOUN
admet-929	136	7	of	of	ADP
admet-929	136	8	cq	cq	NOUN
admet-929	136	9	and	and	CCONJ
admet-929	136	10	hcq	hcq	NOUN
admet-929	136	11	are	be	AUX
admet-929	136	12	below	below	ADP
admet-929	136	13	50	50	NUM
admet-929	136	14	.	.	PUNCT
admet-929	137	1	the	the	DET
admet-929	137	2	measured	measured	ADJ
admet-929	137	3	protein	protein	NOUN
admet-929	137	4	binding	bind	VERB
admet-929	137	5	was	be	AUX
admet-929	137	6	greater	great	ADJ
admet-929	137	7	than	than	SCONJ
admet-929	137	8	has	have	AUX
admet-929	137	9	been	be	AUX
admet-929	137	10	published	publish	VERB
admet-929	137	11	[	[	X
admet-929	137	12	19	19	NUM
admet-929	137	13	]	]	PUNCT
admet-929	137	14	,	,	PUNCT
admet-929	137	15	ranging	range	VERB
admet-929	137	16	from	from	ADP
admet-929	137	17	46	46	NUM
admet-929	137	18	to	to	PART
admet-929	137	19	74	74	NUM
admet-929	137	20	%	%	NOUN
admet-929	137	21	in	in	ADP
admet-929	137	22	patients	patient	NOUN
admet-929	137	23	with	with	ADP
admet-929	137	24	rheumatoid	rheumatoid	NOUN
admet-929	137	25	arthritis	arthritis	NOUN
admet-929	137	26	.	.	PUNCT
admet-929	138	1	strong	strong	ADJ
admet-929	138	2	agp	agp	NOUN
admet-929	138	3	binding	binding	NOUN
admet-929	138	4	was	be	AUX
admet-929	138	5	also	also	ADV
admet-929	138	6	observed	observe	VERB
admet-929	138	7	,	,	PUNCT
admet-929	138	8	being	be	AUX
admet-929	138	9	approximately	approximately	ADV
admet-929	138	10	the	the	DET
admet-929	138	11	same	same	ADJ
admet-929	138	12	as	as	ADP
admet-929	138	13	the	the	DET
admet-929	138	14	albumin	albumin	ADJ
admet-929	138	15	binding	bind	VERB
admet-929	138	16	.	.	PUNCT
admet-929	139	1	table	table	NOUN
admet-929	139	2	4	4	NUM
admet-929	139	3	.	.	PUNCT
admet-929	140	1	the	the	DET
admet-929	140	2	measured	measured	ADJ
admet-929	140	3	phospholipid	phospholipid	NOUN
admet-929	140	4	binding	bind	VERB
admet-929	140	5	(	(	PUNCT
admet-929	140	6	chi	chi	PROPN
admet-929	140	7	iam	iam	PROPN
admet-929	140	8	)	)	PUNCT
admet-929	140	9	,	,	PUNCT
admet-929	140	10	protein	protein	NOUN
admet-929	140	11	binding	bind	VERB
admet-929	140	12	and	and	CCONJ
admet-929	140	13	estimated	estimate	VERB
admet-929	140	14	total	total	ADJ
admet-929	140	15	plasma	plasma	NOUN
admet-929	140	16	protein	protein	NOUN
admet-929	140	17	binding	bind	VERB
admet-929	140	18	(	(	PUNCT
admet-929	140	19	ppb	ppb	NOUN
admet-929	140	20	)	)	PUNCT
admet-929	140	21	based	base	VERB
admet-929	140	22	on	on	ADP
admet-929	140	23	the	the	DET
admet-929	140	24	%	%	NOUN
admet-929	140	25	hsa	hsa	NOUN
admet-929	140	26	and	and	CCONJ
admet-929	140	27	%	%	INTJ
admet-929	140	28	agp	agp	NOUN
admet-929	140	29	binding	binding	NOUN
admet-929	140	30	and	and	CCONJ
admet-929	140	31	the	the	DET
admet-929	140	32	lipophilicity	lipophilicity	NOUN
admet-929	140	33	of	of	ADP
admet-929	140	34	the	the	DET
admet-929	140	35	compounds	compound	NOUN
admet-929	140	36	.	.	PUNCT
admet-929	141	1	the	the	DET
admet-929	141	2	error	error	NOUN
admet-929	141	3	of	of	ADP
admet-929	141	4	the	the	DET
admet-929	141	5	values	value	NOUN
admet-929	141	6	depends	depend	VERB
admet-929	141	7	on	on	ADP
admet-929	141	8	the	the	DET
admet-929	141	9	model	model	NOUN
admet-929	141	10	error	error	NOUN
admet-929	141	11	and	and	CCONJ
admet-929	141	12	the	the	DET
admet-929	141	13	error	error	NOUN
admet-929	141	14	obtained	obtain	VERB
admet-929	141	15	from	from	ADP
admet-929	141	16	fitting	fit	VERB
admet-929	141	17	the	the	DET
admet-929	141	18	calibration	calibration	NOUN
admet-929	141	19	lines	line	NOUN
admet-929	141	20	.	.	PUNCT
admet-929	142	1	the	the	DET
admet-929	142	2	chi	chi	PROPN
admet-929	142	3	iam	iam	PROPN
admet-929	142	4	values	value	NOUN
admet-929	142	5	are	be	AUX
admet-929	142	6	reproducible	reproducible	ADJ
admet-929	142	7	with	with	ADP
admet-929	142	8	±3	±3	ADJ
admet-929	142	9	chi	chi	ADJ
admet-929	142	10	unit	unit	NOUN
admet-929	142	11	,	,	PUNCT
admet-929	142	12	the	the	DET
admet-929	142	13	protein	protein	NOUN
admet-929	142	14	binding	bind	VERB
admet-929	142	15	%	%	NOUN
admet-929	142	16	error	error	NOUN
admet-929	142	17	is	be	AUX
admet-929	142	18	larger	large	ADJ
admet-929	142	19	at	at	ADP
admet-929	142	20	the	the	DET
admet-929	142	21	middle	middle	ADJ
admet-929	142	22	range	range	NOUN
admet-929	142	23	(	(	PUNCT
admet-929	142	24	±	±	NUM
admet-929	142	25	10	10	NUM
admet-929	142	26	%	%	NOUN
admet-929	142	27	)	)	PUNCT
admet-929	142	28	and	and	CCONJ
admet-929	142	29	much	much	ADV
admet-929	142	30	smaller	small	ADJ
admet-929	142	31	above	above	ADP
admet-929	142	32	90	90	NUM
admet-929	142	33	%	%	NOUN
admet-929	142	34	binding	bind	VERB
admet-929	142	35	(	(	PUNCT
admet-929	142	36	±0.1	±0.1	PROPN
admet-929	142	37	%	%	INTJ
admet-929	142	38	)	)	PUNCT
admet-929	142	39	,	,	PUNCT
admet-929	142	40	the	the	DET
admet-929	142	41	estimation	estimation	NOUN
admet-929	142	42	of	of	ADP
admet-929	142	43	the	the	DET
admet-929	142	44	total	total	ADJ
admet-929	142	45	plasma	plasma	NOUN
admet-929	142	46	protein	protein	NOUN
admet-929	142	47	binding	bind	VERB
admet-929	142	48	includes	include	VERB
admet-929	142	49	the	the	DET
admet-929	142	50	model	model	NOUN
admet-929	142	51	error	error	NOUN
admet-929	142	52	of	of	ADP
admet-929	142	53	±	±	NUM
admet-929	142	54	0.36	0.36	NUM
admet-929	142	55	in	in	ADP
admet-929	142	56	log	log	PROPN
admet-929	142	57	k	k	PROPN
admet-929	142	58	ppb	ppb	NOUN
admet-929	142	59	values	value	NOUN
admet-929	142	60	.	.	PUNCT
admet-929	143	1	property	property	NOUN
admet-929	143	2	cq	cq	PROPN
admet-929	143	3	hcq	hcq	PROPN
admet-929	143	4	chi	chi	PROPN
admet-929	143	5	(	(	PUNCT
admet-929	143	6	iam	iam	PROPN
admet-929	143	7	)	)	PUNCT
admet-929	143	8	47	47	NUM
admet-929	143	9	45.4	45.4	NUM
admet-929	143	10	log	log	NOUN
admet-929	143	11	k	k	PROPN
admet-929	143	12	(	(	PUNCT
admet-929	143	13	iam	iam	PROPN
admet-929	143	14	)	)	PUNCT
admet-929	143	15	2.6	2.6	NUM
admet-929	143	16	2.5	2.5	NUM
admet-929	143	17	%	%	NOUN
admet-929	143	18	hsa	hsa	PROPN
admet-929	143	19	bound	bind	VERB
admet-929	143	20	87.6	87.6	NUM
admet-929	143	21	84.9	84.9	NUM
admet-929	143	22	log	log	NOUN
admet-929	143	23	k	k	PROPN
admet-929	143	24	hsa	hsa	PROPN
admet-929	143	25	0.8	0.8	NUM
admet-929	143	26	0.7	0.7	NUM
admet-929	143	27	%	%	NOUN
admet-929	143	28	agp	agp	PROPN
admet-929	143	29	bound	bind	VERB
admet-929	143	30	88.8	88.8	NUM
admet-929	143	31	89.0	89.0	NUM
admet-929	143	32	log	log	NOUN
admet-929	144	1	k	k	PROPN
admet-929	144	2	agp	agp	PROPN
admet-929	144	3	0.9	0.9	NUM
admet-929	144	4	0.9	0.9	NUM
admet-929	144	5	estimated	estimate	VERB
admet-929	144	6	%	%	NOUN
admet-929	144	7	plasma	plasma	NOUN
admet-929	144	8	protein	protein	NOUN
admet-929	144	9	binding	bind	VERB
admet-929	144	10	(	(	PUNCT
admet-929	144	11	ppb	ppb	NOUN
admet-929	144	12	)	)	PUNCT
admet-929	144	13	94.8	94.8	NUM
admet-929	144	14	93.4	93.4	NUM
admet-929	144	15	log	log	NOUN
admet-929	145	1	k	k	PROPN
admet-929	145	2	ppb	ppb	VERB
admet-929	145	3	1.2	1.2	NUM
admet-929	145	4	1.1	1.1	NUM
admet-929	145	5	however	however	ADV
admet-929	145	6	,	,	PUNCT
admet-929	145	7	the	the	DET
admet-929	145	8	agp	agp	NOUN
admet-929	145	9	concentration	concentration	NOUN
admet-929	145	10	in	in	ADP
admet-929	145	11	the	the	DET
admet-929	145	12	plasma	plasma	NOUN
admet-929	145	13	ranges	range	VERB
admet-929	145	14	from	from	ADP
admet-929	145	15	1	1	NUM
admet-929	145	16	to	to	PART
admet-929	145	17	10	10	NUM
admet-929	145	18	%	%	NOUN
admet-929	145	19	while	while	SCONJ
admet-929	145	20	the	the	DET
admet-929	145	21	albumin	albumin	ADJ
admet-929	145	22	concentration	concentration	NOUN
admet-929	145	23	in	in	ADP
admet-929	145	24	the	the	DET
admet-929	145	25	plasma	plasma	NOUN
admet-929	145	26	is	be	AUX
admet-929	145	27	around	around	ADV
admet-929	145	28	60	60	NUM
admet-929	145	29	%	%	NOUN
admet-929	145	30	,	,	PUNCT
admet-929	145	31	being	be	AUX
admet-929	145	32	the	the	DET
admet-929	145	33	most	most	ADV
admet-929	145	34	abundant	abundant	ADJ
admet-929	145	35	protein	protein	NOUN
admet-929	145	36	.	.	PUNCT
admet-929	146	1	it	it	PRON
admet-929	146	2	is	be	AUX
admet-929	146	3	also	also	ADV
admet-929	146	4	well	well	ADV
admet-929	146	5	established	establish	VERB
admet-929	146	6	that	that	SCONJ
admet-929	146	7	agp	agp	PROPN
admet-929	146	8	prefers	prefer	VERB
admet-929	146	9	to	to	PART
admet-929	146	10	bind	bind	VERB
admet-929	146	11	to	to	ADP
admet-929	146	12	positively	positively	ADV
admet-929	146	13	charged	charge	VERB
admet-929	146	14	compounds	compound	NOUN
admet-929	146	15	since	since	SCONJ
admet-929	146	16	it	it	PRON
admet-929	146	17	has	have	AUX
admet-929	146	18	negatively	negatively	ADV
admet-929	146	19	charged	charge	VERB
admet-929	146	20	sialic	sialic	ADJ
admet-929	146	21	acids	acid	NOUN
admet-929	146	22	at	at	ADP
admet-929	146	23	its	its	PRON
admet-929	146	24	binding	bind	VERB
admet-929	146	25	site	site	NOUN
admet-929	146	26	[	[	X
admet-929	146	27	37	37	NUM
admet-929	146	28	]	]	PUNCT
admet-929	146	29	.	.	PUNCT
admet-929	147	1	the	the	DET
admet-929	147	2	lysosomes	lysosome	NOUN
admet-929	147	3	inside	inside	ADP
admet-929	147	4	the	the	DET
admet-929	147	5	cell	cell	NOUN
admet-929	147	6	also	also	ADV
admet-929	147	7	contain	contain	VERB
admet-929	147	8	glycoproteins	glycoprotein	NOUN
admet-929	147	9	that	that	PRON
admet-929	147	10	are	be	AUX
admet-929	147	11	negatively	negatively	ADV
admet-929	147	12	charged	charge	VERB
admet-929	147	13	and	and	CCONJ
admet-929	147	14	attract	attract	VERB
admet-929	147	15	positively	positively	ADV
admet-929	147	16	property	property	NOUN
admet-929	147	17	cq	cq	PROPN
admet-929	147	18	hcq	hcq	PROPN
admet-929	147	19	acd	acd	PROPN
admet-929	147	20	log	log	NOUN
admet-929	147	21	p	p	NOUN
admet-929	147	22	(	(	PUNCT
admet-929	147	23	calculated	calculate	VERB
admet-929	147	24	)	)	PUNCT
admet-929	147	25	4.69	4.69	NUM
admet-929	147	26	3.77	3.77	NUM
admet-929	147	27	chemaxon	chemaxon	NOUN
admet-929	147	28	log	log	NOUN
admet-929	147	29	p	p	NOUN
admet-929	147	30	(	(	PUNCT
admet-929	147	31	calculated	calculate	VERB
admet-929	147	32	)	)	PUNCT
admet-929	147	33	3.93	3.93	NUM
admet-929	147	34	2.89	2.89	NUM
admet-929	147	35	acd	acd	NOUN
admet-929	147	36	log	log	NOUN
admet-929	147	37	d	d	NOUN
admet-929	147	38	(	(	PUNCT
admet-929	147	39	calculated	calculate	VERB
admet-929	147	40	)	)	PUNCT
admet-929	147	41	1.74	1.74	NUM
admet-929	147	42	1.96	1.96	NUM
admet-929	147	43	chemaxon	chemaxon	NOUN
admet-929	147	44	log	log	NOUN
admet-929	147	45	d	d	PROPN
admet-929	147	46	(	(	PUNCT
admet-929	147	47	calculated	calculate	VERB
admet-929	147	48	)	)	PUNCT
admet-929	147	49	0.88	0.88	NUM
admet-929	147	50	0.33	0.33	NUM
admet-929	147	51	measured	measure	VERB
admet-929	147	52	log	log	NOUN
admet-929	147	53	i	i	PRON
admet-929	147	54	(	(	PUNCT
admet-929	147	55	chemspider	chemspider	VERB
admet-929	148	1	[	[	X
admet-929	148	2	32	32	NUM
admet-929	148	3	,	,	PUNCT
admet-929	148	4	33	33	NUM
admet-929	148	5	]	]	PUNCT
admet-929	148	6	)	)	PUNCT
admet-929	148	7	2.68	2.68	NUM
admet-929	148	8	-4.63	-4.63	NUM
admet-929	148	9	1.55	1.55	NUM
admet-929	148	10	–	–	PUNCT
admet-929	148	11	3.85	3.85	NUM
admet-929	148	12	chi	chi	NOUN
admet-929	148	13	log	log	NOUN
admet-929	148	14	d	d	PROPN
admet-929	148	15	(	(	PUNCT
admet-929	148	16	ph	ph	NOUN
admet-929	148	17	7.4	7.4	NUM
admet-929	148	18	)	)	PUNCT
admet-929	148	19	0.79	0.79	NUM
admet-929	148	20	0.66	0.66	NUM
admet-929	149	1	chi	chi	NOUN
admet-929	149	2	log	log	NOUN
admet-929	149	3	p	p	NOUN
admet-929	149	4	2.68	2.68	NUM
admet-929	149	5	2.13	2.13	NUM
admet-929	149	6	chemaxon	chemaxon	NOUN
admet-929	149	7	pks	pks	NOUN
admet-929	149	8	(	(	PUNCT
admet-929	149	9	calculated	calculate	VERB
admet-929	149	10	)	)	PUNCT
admet-929	149	11	10.32	10.32	NUM
admet-929	149	12	9.76	9.76	NUM
admet-929	149	13	admet	admet	PROPN
admet-929	149	14	&	&	CCONJ
admet-929	149	15	dmpk	dmpk	PROPN
admet-929	149	16	9(2	9(2	NUM
admet-929	149	17	)	)	PUNCT
admet-929	149	18	(	(	PUNCT
admet-929	149	19	2021	2021	NUM
admet-929	149	20	)	)	PUNCT
admet-929	149	21	151	151	NUM
admet-929	149	22	-	-	SYM
admet-929	149	23	165	165	NUM
admet-929	149	24	biomimetic	biomimetic	ADJ
admet-929	149	25	properties	property	NOUN
admet-929	149	26	of	of	ADP
admet-929	149	27	chlorquine	chlorquine	NOUN
admet-929	149	28	enantiomers	enantiomer	NOUN
admet-929	149	29	doi	doi	NOUN
admet-929	149	30	:	:	PUNCT
admet-929	149	31	https://doi.org/10.5599/admet.929	https://doi.org/10.5599/admet.929	NOUN
admet-929	149	32	157	157	NUM
admet-929	149	33	charged	charge	VERB
admet-929	149	34	compounds	compound	NOUN
admet-929	149	35	.	.	PUNCT
admet-929	150	1	the	the	DET
admet-929	150	2	strong	strong	ADJ
admet-929	150	3	agp	agp	NOUN
admet-929	150	4	binding	binding	NOUN
admet-929	150	5	of	of	ADP
admet-929	150	6	cq	cq	NOUN
admet-929	150	7	and	and	CCONJ
admet-929	150	8	hcq	hcq	PROPN
admet-929	150	9	may	may	AUX
admet-929	150	10	explain	explain	VERB
admet-929	150	11	the	the	DET
admet-929	150	12	large	large	ADJ
admet-929	150	13	variability	variability	NOUN
admet-929	150	14	of	of	ADP
admet-929	150	15	the	the	DET
admet-929	150	16	plasma	plasma	NOUN
admet-929	150	17	protein	protein	NOUN
admet-929	150	18	binding	bind	VERB
admet-929	150	19	data	datum	NOUN
admet-929	150	20	as	as	ADP
admet-929	150	21	the	the	DET
admet-929	150	22	agp	agp	PROPN
admet-929	150	23	concentration	concentration	NOUN
admet-929	150	24	depends	depend	VERB
admet-929	150	25	on	on	ADP
admet-929	150	26	the	the	DET
admet-929	150	27	disease	disease	NOUN
admet-929	150	28	state	state	NOUN
admet-929	150	29	and	and	CCONJ
admet-929	150	30	it	it	PRON
admet-929	150	31	can	can	AUX
admet-929	150	32	increase	increase	VERB
admet-929	150	33	significantly	significantly	ADV
admet-929	150	34	in	in	ADP
admet-929	150	35	inflammation	inflammation	NOUN
admet-929	150	36	,	,	PUNCT
admet-929	150	37	cancer	cancer	NOUN
admet-929	150	38	and	and	CCONJ
admet-929	150	39	with	with	ADP
admet-929	150	40	age	age	NOUN
admet-929	151	1	[	[	X
admet-929	151	2	38	38	NUM
admet-929	151	3	]	]	PUNCT
admet-929	151	4	.	.	PUNCT
admet-929	152	1	table	table	NOUN
admet-929	152	2	5	5	NUM
admet-929	152	3	shows	show	VERB
admet-929	152	4	the	the	DET
admet-929	152	5	equations	equation	NOUN
admet-929	152	6	of	of	ADP
admet-929	152	7	the	the	DET
admet-929	152	8	models	model	NOUN
admet-929	152	9	that	that	PRON
admet-929	152	10	were	be	AUX
admet-929	152	11	used	use	VERB
admet-929	152	12	to	to	PART
admet-929	152	13	make	make	VERB
admet-929	152	14	estimations	estimation	NOUN
admet-929	152	15	of	of	ADP
admet-929	152	16	the	the	PRON
admet-929	152	17	in	in	ADP
admet-929	152	18	vivo	vivo	ADJ
admet-929	152	19	properties	property	NOUN
admet-929	152	20	of	of	ADP
admet-929	152	21	the	the	DET
admet-929	152	22	drugs	drug	NOUN
admet-929	152	23	from	from	ADP
admet-929	152	24	the	the	DET
admet-929	152	25	measured	measure	VERB
admet-929	152	26	biomimetic	biomimetic	ADJ
admet-929	152	27	hplc	hplc	NOUN
admet-929	152	28	data	datum	NOUN
admet-929	152	29	.	.	PUNCT
admet-929	153	1	note	note	NOUN
admet-929	153	2	,	,	PUNCT
admet-929	153	3	that	that	SCONJ
admet-929	153	4	the	the	DET
admet-929	153	5	log	log	NOUN
admet-929	153	6	k	k	PROPN
admet-929	153	7	hsa	hsa	PROPN
admet-929	153	8	and	and	CCONJ
admet-929	153	9	log	log	VERB
admet-929	153	10	k	k	PROPN
admet-929	153	11	iam	iam	PROPN
admet-929	153	12	data	datum	NOUN
admet-929	153	13	had	have	VERB
admet-929	153	14	to	to	PART
admet-929	153	15	be	be	AUX
admet-929	153	16	transformed	transform	VERB
admet-929	153	17	to	to	PART
admet-929	153	18	log	log	VERB
admet-929	153	19	k	k	PROPN
admet-929	153	20	hsa	hsa	PROPN
admet-929	153	21	and	and	CCONJ
admet-929	153	22	log	log	VERB
admet-929	153	23	k	k	PROPN
admet-929	153	24	iam	iam	PROPN
admet-929	153	25	data	datum	NOUN
admet-929	153	26	as	as	ADP
admet-929	153	27	the	the	DET
admet-929	153	28	measured	measure	VERB
admet-929	153	29	log	log	NOUN
admet-929	153	30	k	k	PROPN
admet-929	153	31	data	datum	NOUN
admet-929	153	32	for	for	ADP
admet-929	153	33	acetophenone	acetophenone	NOUN
admet-929	153	34	homologues	homologue	NOUN
admet-929	153	35	up	up	ADP
admet-929	153	36	to	to	ADP
admet-929	153	37	octanophenone	octanophenone	PRON
admet-929	153	38	did	do	AUX
admet-929	153	39	not	not	PART
admet-929	153	40	show	show	VERB
admet-929	153	41	linear	linear	ADJ
admet-929	153	42	correlation	correlation	NOUN
admet-929	153	43	with	with	ADP
admet-929	153	44	their	their	PRON
admet-929	153	45	octanol	octanol	NOUN
admet-929	153	46	water	water	NOUN
admet-929	153	47	partition	partition	NOUN
admet-929	153	48	coefficients	coefficient	NOUN
admet-929	153	49	(	(	PUNCT
admet-929	153	50	log	log	VERB
admet-929	153	51	p	p	NOUN
admet-929	153	52	)	)	PUNCT
admet-929	154	1	[	[	X
admet-929	154	2	39	39	NUM
admet-929	154	3	]	]	PUNCT
admet-929	154	4	.	.	PUNCT
admet-929	155	1	for	for	ADP
admet-929	155	2	the	the	DET
admet-929	155	3	mechanistic	mechanistic	ADJ
admet-929	155	4	model	model	NOUN
admet-929	155	5	of	of	ADP
admet-929	155	6	the	the	DET
admet-929	155	7	volume	volume	NOUN
admet-929	155	8	of	of	ADP
admet-929	155	9	distribution	distribution	NOUN
admet-929	155	10	,	,	PUNCT
admet-929	155	11	we	we	PRON
admet-929	155	12	converted	convert	VERB
admet-929	155	13	both	both	CCONJ
admet-929	155	14	the	the	DET
admet-929	155	15	measured	measured	ADJ
admet-929	155	16	albumin	albumin	NOUN
admet-929	155	17	and	and	CCONJ
admet-929	155	18	phospholipid	phospholipid	NOUN
admet-929	155	19	binding	bind	VERB
admet-929	155	20	data	datum	NOUN
admet-929	155	21	so	so	SCONJ
admet-929	155	22	that	that	SCONJ
admet-929	155	23	they	they	PRON
admet-929	155	24	showed	show	VERB
admet-929	155	25	linear	linear	ADJ
admet-929	155	26	correlation	correlation	NOUN
admet-929	155	27	with	with	ADP
admet-929	155	28	the	the	DET
admet-929	155	29	linear	linear	ADJ
admet-929	155	30	free	free	ADJ
admet-929	155	31	-	-	PUNCT
admet-929	155	32	energy	energy	NOUN
admet-929	155	33	related	relate	VERB
admet-929	155	34	log	log	NOUN
admet-929	155	35	p	p	NOUN
admet-929	155	36	values	value	NOUN
admet-929	155	37	.	.	PUNCT
admet-929	156	1	thus	thus	ADV
admet-929	156	2	,	,	PUNCT
admet-929	156	3	the	the	DET
admet-929	156	4	regression	regression	NOUN
admet-929	156	5	coefficients	coefficient	VERB
admet-929	156	6	in	in	ADP
admet-929	156	7	linear	linear	ADJ
admet-929	156	8	regression	regression	NOUN
admet-929	156	9	analysis	analysis	NOUN
admet-929	156	10	are	be	AUX
admet-929	156	11	meaningful	meaningful	ADJ
admet-929	156	12	and	and	CCONJ
admet-929	156	13	reflect	reflect	VERB
admet-929	156	14	to	to	ADP
admet-929	156	15	the	the	DET
admet-929	156	16	physiological	physiological	ADJ
admet-929	156	17	proportion	proportion	NOUN
admet-929	156	18	of	of	ADP
admet-929	156	19	the	the	DET
admet-929	156	20	albumin	albumin	NOUN
admet-929	156	21	and	and	CCONJ
admet-929	156	22	phospholipids	phospholipid	NOUN
admet-929	156	23	in	in	ADP
admet-929	156	24	the	the	DET
admet-929	156	25	body	body	NOUN
admet-929	156	26	.	.	PUNCT
admet-929	157	1	the	the	DET
admet-929	157	2	estimated	estimate	VERB
admet-929	157	3	distribution	distribution	NOUN
admet-929	157	4	and	and	CCONJ
admet-929	157	5	tissue	tissue	NOUN
admet-929	157	6	binding	bind	VERB
admet-929	157	7	data	datum	NOUN
admet-929	157	8	for	for	ADP
admet-929	157	9	cq	cq	NOUN
admet-929	157	10	and	and	CCONJ
admet-929	157	11	hcq	hcq	NOUN
admet-929	157	12	were	be	AUX
admet-929	157	13	evaluated	evaluate	VERB
admet-929	157	14	using	use	VERB
admet-929	157	15	the	the	DET
admet-929	157	16	standard	standard	ADJ
admet-929	157	17	6	6	NUM
admet-929	157	18	-	-	PUNCT
admet-929	157	19	min	min	NOUN
admet-929	157	20	hplc	hplc	NOUN
admet-929	158	1	based	base	VERB
admet-929	158	2	measurements	measurement	NOUN
admet-929	158	3	of	of	ADP
admet-929	158	4	biomimetic	biomimetic	ADJ
admet-929	158	5	properties	property	NOUN
admet-929	158	6	(	(	PUNCT
admet-929	158	7	chilogd	chilogd	VERB
admet-929	158	8	at	at	ADP
admet-929	158	9	three	three	NUM
admet-929	158	10	phs	ph	NOUN
admet-929	158	11	,	,	PUNCT
admet-929	158	12	log	log	NOUN
admet-929	158	13	k	k	PROPN
admet-929	158	14	hsa	hsa	PROPN
admet-929	158	15	,	,	PUNCT
admet-929	158	16	log	log	VERB
admet-929	158	17	k	k	PROPN
admet-929	158	18	agp	agp	PROPN
admet-929	158	19	and	and	CCONJ
admet-929	158	20	log	log	VERB
admet-929	158	21	k	k	PROPN
admet-929	158	22	iam	iam	PROPN
admet-929	158	23	)	)	PUNCT
admet-929	158	24	.	.	PUNCT
admet-929	159	1	they	they	PRON
admet-929	159	2	are	be	AUX
admet-929	159	3	based	base	VERB
admet-929	159	4	on	on	ADP
admet-929	159	5	the	the	DET
admet-929	159	6	calibrated	calibrate	VERB
admet-929	159	7	retention	retention	NOUN
admet-929	159	8	times	time	NOUN
admet-929	159	9	obtained	obtain	VERB
admet-929	159	10	on	on	ADP
admet-929	159	11	c-18	c-18	PROPN
admet-929	159	12	,	,	PUNCT
admet-929	159	13	iam	iam	PROPN
admet-929	159	14	,	,	PUNCT
admet-929	159	15	chiralpak	chiralpak	PROPN
admet-929	159	16	hsa	hsa	PROPN
admet-929	159	17	and	and	CCONJ
admet-929	159	18	chiralpak	chiralpak	VERB
admet-929	159	19	agp	agp	NOUN
admet-929	159	20	columns	column	NOUN
admet-929	159	21	.	.	PUNCT
admet-929	160	1	the	the	DET
admet-929	160	2	total	total	ADJ
admet-929	160	3	plasma	plasma	NOUN
admet-929	160	4	protein	protein	NOUN
admet-929	160	5	binding	bind	VERB
admet-929	160	6	,	,	PUNCT
admet-929	160	7	lung	lung	NOUN
admet-929	160	8	tissue	tissue	NOUN
admet-929	160	9	binding	bind	VERB
admet-929	160	10	,	,	PUNCT
admet-929	160	11	drug	drug	NOUN
admet-929	160	12	efficiency	efficiency	NOUN
admet-929	160	13	,	,	PUNCT
admet-929	160	14	brain	brain	NOUN
admet-929	160	15	tissue	tissue	NOUN
admet-929	160	16	binding	bind	VERB
admet-929	160	17	and	and	CCONJ
admet-929	160	18	brain	brain	NOUN
admet-929	160	19	to	to	ADP
admet-929	160	20	blood	blood	NOUN
admet-929	160	21	ratio	ratio	NOUN
admet-929	160	22	,	,	PUNCT
admet-929	160	23	cell	cell	NOUN
admet-929	160	24	partition	partition	NOUN
admet-929	160	25	coefficient	coefficient	NOUN
admet-929	160	26	and	and	CCONJ
admet-929	160	27	lung	lung	NOUN
admet-929	160	28	tissue	tissue	NOUN
admet-929	160	29	binding	bind	VERB
admet-929	160	30	have	have	AUX
admet-929	160	31	been	be	AUX
admet-929	160	32	calculated	calculate	VERB
admet-929	160	33	using	use	VERB
admet-929	160	34	the	the	DET
admet-929	160	35	equations	equation	NOUN
admet-929	160	36	listed	list	VERB
admet-929	160	37	in	in	ADP
admet-929	160	38	table	table	NOUN
admet-929	160	39	5	5	NUM
admet-929	160	40	and	and	CCONJ
admet-929	160	41	are	be	AUX
admet-929	160	42	shown	show	VERB
admet-929	160	43	in	in	ADP
admet-929	160	44	table	table	NOUN
admet-929	160	45	6	6	NUM
admet-929	160	46	.	.	PUNCT
admet-929	160	47	table	table	NOUN
admet-929	160	48	5	5	NUM
admet-929	160	49	.	.	PUNCT
admet-929	161	1	the	the	DET
admet-929	161	2	published	publish	VERB
admet-929	161	3	and	and	CCONJ
admet-929	161	4	validated	validated	ADJ
admet-929	161	5	model	model	NOUN
admet-929	161	6	equations	equation	NOUN
admet-929	161	7	that	that	PRON
admet-929	161	8	are	be	AUX
admet-929	161	9	used	use	VERB
admet-929	161	10	together	together	ADV
admet-929	161	11	with	with	ADP
admet-929	161	12	the	the	DET
admet-929	161	13	measured	measure	VERB
admet-929	161	14	properties	property	NOUN
admet-929	161	15	to	to	PART
admet-929	161	16	estimate	estimate	VERB
admet-929	161	17	the	the	DET
admet-929	161	18	in	in	ADP
admet-929	161	19	vivo	vivo	ADJ
admet-929	161	20	distribution	distribution	NOUN
admet-929	161	21	behaviour	behaviour	NOUN
admet-929	161	22	of	of	ADP
admet-929	161	23	drugs	drug	NOUN
admet-929	161	24	.	.	PUNCT
admet-929	162	1	(	(	PUNCT
admet-929	162	2	abbreviations	abbreviation	NOUN
admet-929	162	3	:	:	PUNCT
admet-929	162	4	iam	iam	PROPN
admet-929	162	5	=	=	PRON
admet-929	162	6	immobilized	immobilize	VERB
admet-929	162	7	artificial	artificial	ADJ
admet-929	162	8	membrane	membrane	NOUN
admet-929	162	9	;	;	PUNCT
admet-929	162	10	hsa	hsa	PROPN
admet-929	162	11	=	=	SYM
admet-929	162	12	human	human	ADJ
admet-929	162	13	serum	serum	NOUN
admet-929	162	14	albumin	albumin	NOUN
admet-929	162	15	;	;	PUNCT
admet-929	162	16	vd	vd	NOUN
admet-929	162	17	=	=	SYM
admet-929	162	18	volume	volume	NOUN
admet-929	162	19	of	of	ADP
admet-929	162	20	distribution	distribution	NOUN
admet-929	162	21	;	;	PUNCT
admet-929	162	22	vdu	vdu	PROPN
admet-929	162	23	=	=	PUNCT
admet-929	162	24	unbound	unbound	NOUN
admet-929	162	25	volume	volume	NOUN
admet-929	162	26	of	of	ADP
admet-929	162	27	distribution	distribution	NOUN
admet-929	162	28	,	,	PUNCT
admet-929	162	29	demax	demax	NOUN
admet-929	162	30	=	=	SYM
admet-929	162	31	maximum	maximum	ADJ
admet-929	162	32	drug	drug	NOUN
admet-929	162	33	efficiency	efficiency	NOUN
admet-929	162	34	;	;	PUNCT
admet-929	162	35	btb	btb	NOUN
admet-929	162	36	=	=	PUNCT
admet-929	162	37	brain	brain	NOUN
admet-929	162	38	tissue	tissue	NOUN
admet-929	162	39	binding	binding	NOUN
admet-929	162	40	;	;	PUNCT
admet-929	162	41	ppb	ppb	NOUN
admet-929	162	42	=	=	NOUN
admet-929	162	43	plasma	plasma	NOUN
admet-929	162	44	protein	protein	NOUN
admet-929	162	45	binding	bind	VERB
admet-929	162	46	,	,	PUNCT
admet-929	162	47	fu	fu	NOUN
admet-929	162	48	=	=	PUNCT
admet-929	162	49	unbound	unbound	NOUN
admet-929	162	50	fraction	fraction	NOUN
admet-929	162	51	;	;	PUNCT
admet-929	162	52	kbb	kbb	PROPN
admet-929	162	53	=	=	PUNCT
admet-929	162	54	brain	brain	NOUN
admet-929	162	55	to	to	ADP
admet-929	162	56	blood	blood	NOUN
admet-929	162	57	partition	partition	NOUN
admet-929	162	58	coefficient	coefficient	NOUN
admet-929	162	59	;	;	PUNCT
admet-929	162	60	kpcell	kpcell	ADJ
admet-929	162	61	=	=	PUNCT
admet-929	162	62	cell	cell	NOUN
admet-929	162	63	partition	partition	NOUN
admet-929	162	64	coefficient	coefficient	NOUN
admet-929	162	65	;	;	PUNCT
admet-929	162	66	ltb	ltb	PROPN
admet-929	162	67	=	=	PUNCT
admet-929	162	68	lung	lung	NOUN
admet-929	162	69	tissue	tissue	NOUN
admet-929	162	70	binding	bind	VERB
admet-929	162	71	)	)	PUNCT
admet-929	162	72	log	log	NOUN
admet-929	162	73	k	k	PROPN
admet-929	162	74	iam	iam	PROPN
admet-929	163	1	[	[	X
admet-929	163	2	43	43	NUM
admet-929	163	3	]	]	X
admet-929	163	4	=	=	SYM
admet-929	163	5	0.29*e(0.026chi(iam)+0.42	0.29*e(0.026chi(iam)+0.42	NOUN
admet-929	163	6	)	)	PUNCT
admet-929	163	7	+0.7	+0.7	NUM
admet-929	163	8	log	log	NOUN
admet-929	163	9	k	k	PROPN
admet-929	163	10	iam	iam	PROPN
admet-929	164	1	[	[	X
admet-929	164	2	43	43	NUM
admet-929	164	3	]	]	X
admet-929	164	4	=	=	SYM
admet-929	164	5	0.046*chi(iam)+0.42	0.046*chi(iam)+0.42	X
admet-929	164	6	phospholipidotic	phospholipidotic	ADJ
admet-929	164	7	potential	potential	NOUN
admet-929	164	8	(	(	PUNCT
admet-929	164	9	cadlikeness	cadlikeness	NOUN
admet-929	164	10	)	)	PUNCT
admet-929	164	11	=	=	SYM
admet-929	165	1	chi	chi	NOUN
admet-929	165	2	(	(	PUNCT
admet-929	165	3	iam	iam	PROPN
admet-929	165	4	)	)	PUNCT
admet-929	165	5	+	+	CCONJ
admet-929	165	6	(	(	PUNCT
admet-929	165	7	chi	chi	NOUN
admet-929	165	8	at	at	ADP
admet-929	165	9	ph	ph	PROPN
admet-929	165	10	10.5	10.5	NUM
admet-929	165	11	–	–	PUNCT
admet-929	165	12	chi	chi	NOUN
admet-929	165	13	at	at	ADP
admet-929	165	14	ph	ph	PROPN
admet-929	165	15	7.4	7.4	NUM
admet-929	165	16	)	)	PUNCT
admet-929	165	17	log	log	NOUN
admet-929	165	18	k	k	PROPN
admet-929	165	19	hsa	hsa	PROPN
admet-929	166	1	[	[	X
admet-929	166	2	43	43	NUM
admet-929	166	3	]	]	X
admet-929	166	4	=	=	X
admet-929	166	5	elog	elog	PROPN
admet-929	166	6	k(hsa	k(hsa	NOUN
admet-929	166	7	)	)	PUNCT
admet-929	166	8	log	log	NOUN
admet-929	166	9	k	k	PROPN
admet-929	166	10	hsa	hsa	PROPN
admet-929	167	1	[	[	X
admet-929	167	2	30	30	NUM
admet-929	167	3	]	]	X
admet-929	167	4	=	=	PUNCT
admet-929	167	5	log	log	NOUN
admet-929	167	6	(	(	PUNCT
admet-929	167	7	%	%	INTJ
admet-929	167	8	hsabound/(101%hsa	hsabound/(101%hsa	NOUN
admet-929	167	9	bound	bind	VERB
admet-929	167	10	)	)	PUNCT
admet-929	167	11	)	)	PUNCT
admet-929	167	12	estimated	estimate	VERB
admet-929	167	13	log	log	NOUN
admet-929	167	14	vd	vd	NOUN
admet-929	168	1	[	[	X
admet-929	168	2	43,44	43,44	X
admet-929	168	3	]	]	X
admet-929	168	4	=	=	SYM
admet-929	168	5	0.44*log	0.44*log	PROPN
admet-929	168	6	k	k	PROPN
admet-929	168	7	iam	iam	PROPN
admet-929	168	8	-0.22*log	-0.22*log	PROPN
admet-929	168	9	k	k	PROPN
admet-929	168	10	hsa	hsa	PROPN
admet-929	168	11	–	–	PUNCT
admet-929	168	12	0.62	0.62	NUM
admet-929	168	13	estimated	estimate	VERB
admet-929	168	14	log	log	NOUN
admet-929	168	15	vdu[27	vdu[27	NOUN
admet-929	168	16	]	]	X
admet-929	169	1	=	=	SYM
admet-929	169	2	0.23*log	0.23*log	PROPN
admet-929	169	3	k	k	PROPN
admet-929	169	4	hsa	hsa	PROPN
admet-929	169	5	+0.43*log	+0.43*log	PROPN
admet-929	169	6	k	k	PROPN
admet-929	169	7	iam	iam	PROPN
admet-929	169	8	-0.72	-0.72	PROPN
admet-929	169	9	demax	demax	PROPN
admet-929	169	10	[	[	X
admet-929	169	11	45	45	NUM
admet-929	169	12	]	]	X
admet-929	169	13	=	=	SYM
admet-929	169	14	100	100	NUM
admet-929	169	15	/	/	SYM
admet-929	169	16	vdu	vdu	PROPN
admet-929	169	17	log	log	NOUN
admet-929	169	18	k	k	X
admet-929	169	19	btb	btb	NOUN
admet-929	169	20	[	[	X
admet-929	169	21	31	31	NUM
admet-929	169	22	]	]	X
admet-929	169	23	=	=	SYM
admet-929	169	24	1.29*log	1.29*log	NUM
admet-929	169	25	k	k	PROPN
admet-929	169	26	iam+1.03*log	iam+1.03*log	PROPN
admet-929	170	1	k	k	PROPN
admet-929	170	2	hsa-2.37	hsa-2.37	PROPN
admet-929	170	3	log	log	NOUN
admet-929	170	4	k	k	X
admet-929	170	5	(	(	PUNCT
admet-929	170	6	ppb)[31	ppb)[31	X
admet-929	170	7	]	]	X
admet-929	170	8	=	=	SYM
admet-929	170	9	0.98∗log	0.98∗log	NUM
admet-929	170	10	𝑘	𝑘	X
admet-929	170	11	𝐻𝑆𝐴+0.19∗log	𝐻𝑆𝐴+0.19∗log	PROPN
admet-929	170	12	𝑘	𝑘	DET
admet-929	170	13	𝐴𝐺𝑃+0.031∗chi	𝐴𝐺𝑃+0.031∗chi	NOUN
admet-929	170	14	log	log	NOUN
admet-929	171	1	d	d	NOUN
admet-929	171	2	7.4−0.20	7.4−0.20	NUM
admet-929	171	3	%	%	NOUN
admet-929	171	4	btb	btb	ADP
admet-929	171	5	[	[	NOUN
admet-929	171	6	31	31	NUM
admet-929	171	7	]	]	X
admet-929	171	8	=	=	SYM
admet-929	172	1	100	100	NUM
admet-929	172	2	*	*	NUM
admet-929	172	3	10log	10log	NOUN
admet-929	172	4	k	k	NOUN
admet-929	172	5	btb/(1	btb/(1	PROPN
admet-929	173	1	+	+	PROPN
admet-929	173	2	10log	10log	X
admet-929	173	3	k	k	ADJ
admet-929	173	4	btb	btb	NOUN
admet-929	173	5	)	)	PUNCT
admet-929	173	6	%	%	NOUN
admet-929	173	7	ppb	ppb	NOUN
admet-929	174	1	[	[	X
admet-929	174	2	31	31	NUM
admet-929	174	3	]	]	X
admet-929	174	4	=	=	SYM
admet-929	174	5	100	100	NUM
admet-929	174	6	*	*	NUM
admet-929	174	7	10log	10log	NOUN
admet-929	175	1	k	k	PRON
admet-929	175	2	ppb/(1	ppb/(1	PUNCT
admet-929	175	3	+	+	ADJ
admet-929	175	4	10log	10log	ADJ
admet-929	175	5	k	k	PROPN
admet-929	175	6	ppb	ppb	NOUN
admet-929	175	7	)	)	PUNCT
admet-929	175	8	fu	fu	NOUN
admet-929	175	9	btb	btb	NOUN
admet-929	175	10	and	and	CCONJ
admet-929	175	11	ppb	ppb	VERB
admet-929	176	1	[	[	X
admet-929	176	2	31	31	NUM
admet-929	176	3	]	]	X
admet-929	176	4	=	=	SYM
admet-929	176	5	(	(	PUNCT
admet-929	176	6	100-%btb)/100	100-%btb)/100	NUM
admet-929	176	7	and	and	CCONJ
admet-929	176	8	(	(	PUNCT
admet-929	176	9	100	100	NUM
admet-929	176	10	%	%	NOUN
admet-929	176	11	-%ppb)/100	-%ppb)/100	PROPN
admet-929	176	12	kbb	kbb	PROPN
admet-929	177	1	[	[	X
admet-929	177	2	31	31	NUM
admet-929	177	3	]	]	X
admet-929	177	4	=	=	SYM
admet-929	177	5	fuppb	fuppb	ADJ
admet-929	177	6	/	/	SYM
admet-929	177	7	fubtb	fubtb	NOUN
admet-929	177	8	log	log	NOUN
admet-929	177	9	kpcell	kpcell	NOUN
admet-929	178	1	[	[	X
admet-929	178	2	46	46	NUM
admet-929	178	3	]	]	X
admet-929	178	4	=	=	SYM
admet-929	178	5	1.1log	1.1log	NUM
admet-929	179	1	k	k	NOUN
admet-929	179	2	iam-1.9	iam-1.9	ADV
admet-929	180	1	log	log	VERB
admet-929	180	2	k	k	PROPN
admet-929	180	3	ltb	ltb	PROPN
admet-929	181	1	[	[	X
admet-929	181	2	31	31	NUM
admet-929	181	3	]	]	PUNCT
admet-929	181	4	=	=	SYM
admet-929	181	5	0.49*log	0.49*log	PROPN
admet-929	181	6	k	k	PROPN
admet-929	181	7	ppb+0.34chilog	ppb+0.34chilog	PROPN
admet-929	181	8	d-0.069	d-0.069	PROPN
admet-929	181	9	%	%	NOUN
admet-929	181	10	ltb	ltb	PROPN
admet-929	182	1	[	[	X
admet-929	182	2	31	31	NUM
admet-929	182	3	]	]	X
admet-929	182	4	=	=	SYM
admet-929	182	5	100	100	NUM
admet-929	182	6	*	*	SYM
admet-929	182	7	10	10	NUM
admet-929	182	8	logkltb	logkltb	NOUN
admet-929	182	9	/(1	/(1	PUNCT
admet-929	183	1	+	+	PROPN
admet-929	183	2	10	10	NUM
admet-929	183	3	logkltb	logkltb	NOUN
admet-929	183	4	)	)	PUNCT
admet-929	184	1	it	it	PRON
admet-929	184	2	can	can	AUX
admet-929	184	3	be	be	AUX
admet-929	184	4	seen	see	VERB
admet-929	184	5	from	from	ADP
admet-929	184	6	table	table	NOUN
admet-929	184	7	6	6	NUM
admet-929	184	8	that	that	SCONJ
admet-929	184	9	both	both	DET
admet-929	184	10	compounds	compound	NOUN
admet-929	184	11	have	have	VERB
admet-929	184	12	cad	cad	NOUN
admet-929	184	13	-	-	PUNCT
admet-929	184	14	likeness	likeness	NOUN
admet-929	184	15	values	value	NOUN
admet-929	184	16	greater	great	ADJ
admet-929	184	17	than	than	ADP
admet-929	184	18	50	50	NUM
admet-929	184	19	,	,	PUNCT
admet-929	184	20	which	which	PRON
admet-929	184	21	indicates	indicate	VERB
admet-929	184	22	that	that	SCONJ
admet-929	184	23	both	both	PRON
admet-929	184	24	have	have	VERB
admet-929	184	25	phospholipidotic	phospholipidotic	ADJ
admet-929	184	26	potential	potential	NOUN
admet-929	184	27	.	.	PUNCT
admet-929	185	1	it	it	PRON
admet-929	185	2	is	be	AUX
admet-929	185	3	known	know	VERB
admet-929	185	4	that	that	SCONJ
admet-929	185	5	chloroquine	chloroquine	NOUN
admet-929	185	6	causes	cause	VERB
admet-929	185	7	phospholipidosis	phospholipidosis	NOUN
admet-929	185	8	both	both	CCONJ
admet-929	185	9	in	in	ADP
admet-929	185	10	animals	animal	NOUN
admet-929	185	11	and	and	CCONJ
admet-929	185	12	in	in	ADP
admet-929	185	13	human	human	ADJ
admet-929	185	14	[	[	X
admet-929	185	15	40	40	NUM
admet-929	185	16	-	-	SYM
admet-929	185	17	42	42	NUM
admet-929	185	18	]	]	PUNCT
admet-929	185	19	.	.	PUNCT
admet-929	186	1	however	however	ADV
admet-929	186	2	,	,	PUNCT
admet-929	186	3	the	the	DET
admet-929	186	4	phospholipidotic	phospholipidotic	ADJ
admet-929	186	5	potential	potential	NOUN
admet-929	186	6	of	of	ADP
admet-929	186	7	hcq	hcq	NOUN
admet-929	186	8	is	be	AUX
admet-929	186	9	much	much	ADV
admet-929	186	10	less	less	ADJ
admet-929	186	11	than	than	ADP
admet-929	186	12	cq	cq	PROPN
admet-929	186	13	.	.	PUNCT
admet-929	187	1	although	although	SCONJ
admet-929	187	2	the	the	DET
admet-929	187	3	phospholipid	phospholipid	NOUN
admet-929	187	4	-	-	PUNCT
admet-929	187	5	bindings	binding	NOUN
admet-929	187	6	(	(	PUNCT
admet-929	187	7	chi	chi	PROPN
admet-929	187	8	iam	iam	PROPN
admet-929	187	9	)	)	PUNCT
admet-929	187	10	were	be	AUX
admet-929	187	11	not	not	PART
admet-929	187	12	very	very	ADV
admet-929	187	13	different	different	ADJ
admet-929	187	14	,	,	PUNCT
admet-929	187	15	the	the	DET
admet-929	187	16	greater	great	ADJ
admet-929	187	17	difference	difference	NOUN
admet-929	187	18	in	in	ADP
admet-929	187	19	cadlikeness	cadlikeness	ADJ
admet-929	187	20	values	value	NOUN
admet-929	187	21	is	be	AUX
admet-929	187	22	due	due	ADJ
admet-929	187	23	to	to	ADP
admet-929	187	24	the	the	DET
admet-929	187	25	larger	large	ADJ
admet-929	187	26	percentage	percentage	NOUN
admet-929	187	27	of	of	ADP
admet-929	187	28	the	the	DET
admet-929	187	29	positively	positively	ADV
admet-929	187	30	charged	charge	VERB
admet-929	187	31	form	form	NOUN
admet-929	187	32	of	of	ADP
admet-929	187	33	cq	cq	NOUN
admet-929	187	34	than	than	ADP
admet-929	187	35	in	in	ADP
admet-929	187	36	hcq	hcq	NOUN
admet-929	187	37	.	.	PUNCT
admet-929	188	1	it	it	PRON
admet-929	188	2	is	be	AUX
admet-929	188	3	obvious	obvious	ADJ
admet-929	188	4	from	from	ADP
admet-929	188	5	the	the	DET
admet-929	188	6	lower	low	ADJ
admet-929	188	7	acid	acid	NOUN
admet-929	188	8	dissociation	dissociation	NOUN
admet-929	188	9	constant	constant	ADJ
admet-929	188	10	of	of	ADP
admet-929	188	11	hcq	hcq	NOUN
admet-929	188	12	and	and	CCONJ
admet-929	188	13	the	the	DET
admet-929	188	14	smaller	small	ADJ
admet-929	188	15	difference	difference	NOUN
admet-929	188	16	between	between	ADP
admet-929	188	17	the	the	DET
admet-929	188	18	chilogp	chilogp	NOUN
admet-929	188	19	https://doi.org/10.5599/admet.929	https://doi.org/10.5599/admet.929	NOUN
admet-929	188	20	klara	klara	PROPN
admet-929	188	21	valko	valko	PROPN
admet-929	188	22	and	and	CCONJ
admet-929	188	23	tong	tong	PROPN
admet-929	188	24	zhang	zhang	PROPN
admet-929	188	25	admet	admet	PROPN
admet-929	188	26	&	&	CCONJ
admet-929	188	27	dmpk	dmpk	PROPN
admet-929	188	28	9(2	9(2	NUM
admet-929	188	29	)	)	PUNCT
admet-929	188	30	(	(	PUNCT
admet-929	188	31	2021	2021	NUM
admet-929	188	32	)	)	PUNCT
admet-929	188	33	151	151	NUM
admet-929	188	34	-	-	SYM
admet-929	188	35	165	165	NUM
admet-929	188	36	158	158	NUM
admet-929	188	37	and	and	CCONJ
admet-929	188	38	chilogd	chilogd	ADJ
admet-929	188	39	values	value	NOUN
admet-929	188	40	(	(	PUNCT
admet-929	188	41	see	see	VERB
admet-929	188	42	table	table	NOUN
admet-929	188	43	3	3	NUM
admet-929	188	44	)	)	PUNCT
admet-929	188	45	.	.	PUNCT
admet-929	189	1	it	it	PRON
admet-929	189	2	also	also	ADV
admet-929	189	3	implies	imply	VERB
admet-929	189	4	that	that	SCONJ
admet-929	189	5	hcq	hcq	NOUN
admet-929	189	6	is	be	AUX
admet-929	189	7	less	less	ADV
admet-929	189	8	likely	likely	ADJ
admet-929	189	9	to	to	PART
admet-929	189	10	cause	cause	VERB
admet-929	189	11	herg	herg	NOUN
admet-929	189	12	inhibition	inhibition	NOUN
admet-929	189	13	and	and	CCONJ
admet-929	189	14	promiscuous	promiscuous	ADJ
admet-929	189	15	binding	binding	NOUN
admet-929	189	16	and	and	CCONJ
admet-929	189	17	in	in	ADP
admet-929	189	18	general	general	ADJ
admet-929	189	19	,	,	PUNCT
admet-929	189	20	fewer	few	ADJ
admet-929	189	21	side	side	NOUN
admet-929	189	22	effects	effect	NOUN
admet-929	189	23	.	.	PUNCT
admet-929	190	1	based	base	VERB
admet-929	190	2	on	on	ADP
admet-929	190	3	the	the	DET
admet-929	190	4	measured	measure	VERB
admet-929	190	5	data	datum	NOUN
admet-929	190	6	,	,	PUNCT
admet-929	190	7	the	the	DET
admet-929	190	8	expected	expect	VERB
admet-929	190	9	brain	brain	NOUN
admet-929	190	10	tissue	tissue	NOUN
admet-929	190	11	binding	bind	VERB
admet-929	190	12	did	do	AUX
admet-929	190	13	not	not	PART
admet-929	190	14	show	show	VERB
admet-929	190	15	a	a	DET
admet-929	190	16	significant	significant	ADJ
admet-929	190	17	difference	difference	NOUN
admet-929	190	18	between	between	ADP
admet-929	190	19	cq	cq	NOUN
admet-929	190	20	and	and	CCONJ
admet-929	190	21	hcq	hcq	NOUN
admet-929	190	22	.	.	PUNCT
admet-929	191	1	on	on	ADP
admet-929	191	2	the	the	DET
admet-929	191	3	contrary	contrary	NOUN
admet-929	191	4	,	,	PUNCT
admet-929	191	5	the	the	DET
admet-929	191	6	brain	brain	NOUN
admet-929	191	7	to	to	ADP
admet-929	191	8	blood	blood	NOUN
admet-929	191	9	ratio	ratio	NOUN
admet-929	191	10	is	be	AUX
admet-929	191	11	smaller	small	ADJ
admet-929	191	12	in	in	ADP
admet-929	191	13	hcq	hcq	NOUN
admet-929	191	14	than	than	ADP
admet-929	191	15	cq	cq	NOUN
admet-929	191	16	due	due	ADP
admet-929	191	17	to	to	ADP
admet-929	191	18	the	the	DET
admet-929	191	19	slightly	slightly	ADV
admet-929	191	20	stronger	strong	ADJ
admet-929	191	21	agp	agp	NOUN
admet-929	191	22	binding	binding	NOUN
admet-929	191	23	of	of	ADP
admet-929	191	24	hcq	hcq	NOUN
admet-929	191	25	that	that	PRON
admet-929	191	26	keeps	keep	VERB
admet-929	191	27	the	the	DET
admet-929	191	28	compound	compound	NOUN
admet-929	191	29	in	in	ADP
admet-929	191	30	the	the	DET
admet-929	191	31	plasma	plasma	NOUN
admet-929	191	32	compartment	compartment	NOUN
admet-929	191	33	.	.	PUNCT
admet-929	192	1	table	table	NOUN
admet-929	192	2	6	6	NUM
admet-929	192	3	.	.	PUNCT
admet-929	193	1	the	the	DET
admet-929	193	2	estimated	estimate	VERB
admet-929	193	3	biomimetic	biomimetic	ADJ
admet-929	193	4	properties	property	NOUN
admet-929	193	5	of	of	ADP
admet-929	193	6	cq	cq	NOUN
admet-929	193	7	and	and	CCONJ
admet-929	193	8	hcq	hcq	PROPN
admet-929	193	9	interestingly	interestingly	ADV
admet-929	193	10	the	the	DET
admet-929	193	11	expected	expect	VERB
admet-929	193	12	volume	volume	NOUN
admet-929	193	13	of	of	ADP
admet-929	193	14	distribution	distribution	NOUN
admet-929	193	15	based	base	VERB
admet-929	193	16	on	on	ADP
admet-929	193	17	the	the	DET
admet-929	193	18	measured	measure	VERB
admet-929	193	19	biomimetic	biomimetic	ADJ
admet-929	193	20	properties	property	NOUN
admet-929	193	21	is	be	AUX
admet-929	193	22	6.9	6.9	NUM
admet-929	193	23	and	and	CCONJ
admet-929	193	24	5.8	5.8	NUM
admet-929	193	25	l	l	NOUN
admet-929	193	26	/	/	SYM
admet-929	193	27	kg	kg	PROPN
admet-929	193	28	for	for	ADP
admet-929	193	29	cq	cq	PROPN
admet-929	193	30	and	and	CCONJ
admet-929	193	31	hcq	hcq	NOUN
admet-929	193	32	,	,	PUNCT
admet-929	193	33	respectively	respectively	ADV
admet-929	193	34	,	,	PUNCT
admet-929	193	35	which	which	PRON
admet-929	193	36	is	be	AUX
admet-929	193	37	not	not	PART
admet-929	193	38	as	as	ADV
admet-929	193	39	high	high	ADJ
admet-929	193	40	as	as	ADP
admet-929	193	41	over	over	ADP
admet-929	193	42	100	100	NUM
admet-929	193	43	l	l	NOUN
admet-929	193	44	/	/	SYM
admet-929	193	45	kg	kg	PROPN
admet-929	193	46	as	as	SCONJ
admet-929	193	47	has	have	AUX
admet-929	193	48	been	be	AUX
admet-929	193	49	described	describe	VERB
admet-929	193	50	in	in	ADP
admet-929	193	51	the	the	DET
admet-929	193	52	literature	literature	NOUN
admet-929	194	1	[	[	X
admet-929	194	2	16,4749	16,4749	X
admet-929	194	3	]	]	X
admet-929	194	4	.	.	PUNCT
admet-929	195	1	the	the	DET
admet-929	195	2	vd	vd	NOUN
admet-929	195	3	of	of	ADP
admet-929	195	4	cq	cq	PROPN
admet-929	195	5	was	be	AUX
admet-929	195	6	116	116	NUM
admet-929	195	7	to	to	ADP
admet-929	195	8	285	285	NUM
admet-929	195	9	l	l	NOUN
admet-929	195	10	/	/	SYM
admet-929	195	11	kg	kg	PROPN
admet-929	195	12	in	in	ADP
admet-929	195	13	healthy	healthy	ADJ
admet-929	195	14	volunteers	volunteer	NOUN
admet-929	195	15	while	while	SCONJ
admet-929	195	16	hcq	hcq	PROPN
admet-929	195	17	was	be	AUX
admet-929	195	18	reported	report	VERB
admet-929	195	19	to	to	PART
admet-929	195	20	have	have	VERB
admet-929	195	21	a	a	DET
admet-929	195	22	much	much	ADV
admet-929	195	23	higher	high	ADJ
admet-929	195	24	volume	volume	NOUN
admet-929	195	25	of	of	ADP
admet-929	195	26	distribution	distribution	NOUN
admet-929	195	27	at	at	ADP
admet-929	195	28	above	above	ADP
admet-929	195	29	4000	4000	NUM
admet-929	195	30	l	l	NOUN
admet-929	195	31	/	/	SYM
admet-929	195	32	kg	kg	PROPN
admet-929	196	1	[	[	X
admet-929	196	2	48	48	NUM
admet-929	196	3	]	]	PUNCT
admet-929	196	4	.	.	PUNCT
admet-929	197	1	tett	tett	NOUN
admet-929	197	2	et	et	PROPN
admet-929	197	3	al	al	PROPN
admet-929	197	4	.	.	PUNCT
admet-929	198	1	[	[	X
admet-929	198	2	50	50	NUM
admet-929	198	3	]	]	PUNCT
admet-929	198	4	,	,	PUNCT
admet-929	198	5	reported	report	VERB
admet-929	198	6	a	a	DET
admet-929	198	7	range	range	NOUN
admet-929	198	8	of	of	ADP
admet-929	198	9	steady	steady	ADJ
admet-929	198	10	-	-	PUNCT
admet-929	198	11	state	state	NOUN
admet-929	198	12	vd	vd	NOUN
admet-929	198	13	values	value	NOUN
admet-929	198	14	for	for	ADP
admet-929	198	15	hcq	hcq	NOUN
admet-929	198	16	ranging	range	VERB
admet-929	198	17	from	from	ADP
admet-929	198	18	2402	2402	NUM
admet-929	198	19	to	to	ADP
admet-929	198	20	8346	8346	NUM
admet-929	198	21	l	l	NOUN
admet-929	198	22	that	that	PRON
admet-929	198	23	are	be	AUX
admet-929	198	24	equivalent	equivalent	ADJ
admet-929	198	25	to	to	ADP
admet-929	198	26	34.3	34.3	NUM
admet-929	198	27	to119	to119	PROPN
admet-929	198	28	l	l	NOUN
admet-929	198	29	/	/	SYM
admet-929	198	30	kg	kg	PROPN
admet-929	198	31	.	.	PUNCT
admet-929	199	1	the	the	DET
admet-929	199	2	volume	volume	NOUN
admet-929	199	3	of	of	ADP
admet-929	199	4	distribution	distribution	NOUN
admet-929	199	5	was	be	AUX
admet-929	199	6	5	5	NUM
admet-929	199	7	to	to	PART
admet-929	199	8	7	7	NUM
admet-929	199	9	times	time	NOUN
admet-929	199	10	greater	great	ADJ
admet-929	199	11	when	when	SCONJ
admet-929	199	12	the	the	DET
admet-929	199	13	plasma	plasma	NOUN
admet-929	199	14	concentration	concentration	NOUN
admet-929	199	15	was	be	AUX
admet-929	199	16	considered	consider	VERB
admet-929	199	17	instead	instead	ADV
admet-929	199	18	of	of	ADP
admet-929	199	19	the	the	DET
admet-929	199	20	blood	blood	NOUN
admet-929	199	21	concentration	concentration	NOUN
admet-929	199	22	as	as	SCONJ
admet-929	199	23	the	the	DET
admet-929	199	24	blood	blood	NOUN
admet-929	199	25	/	/	SYM
admet-929	199	26	plasma	plasma	NOUN
admet-929	199	27	ratio	ratio	NOUN
admet-929	199	28	was	be	AUX
admet-929	199	29	reported	report	VERB
admet-929	199	30	to	to	PART
admet-929	199	31	be	be	AUX
admet-929	199	32	5	5	NUM
admet-929	199	33	to	to	PART
admet-929	199	34	7	7	NUM
admet-929	199	35	.	.	PUNCT
admet-929	200	1	the	the	DET
admet-929	200	2	reported	report	VERB
admet-929	200	3	plasma	plasma	NOUN
admet-929	200	4	protein	protein	NOUN
admet-929	200	5	binding	bind	VERB
admet-929	200	6	value	value	NOUN
admet-929	200	7	that	that	PRON
admet-929	200	8	was	be	AUX
admet-929	200	9	determined	determine	VERB
admet-929	200	10	in	in	ADP
admet-929	200	11	1986	1986	NUM
admet-929	200	12	was	be	AUX
admet-929	200	13	66.6	66.6	NUM
admet-929	200	14	%	%	NOUN
admet-929	201	1	[	[	X
admet-929	201	2	20	20	NUM
admet-929	201	3	]	]	PUNCT
admet-929	201	4	;	;	PUNCT
admet-929	201	5	enantioselective	enantioselective	ADJ
admet-929	201	6	plasma	plasma	NOUN
admet-929	201	7	protein	protein	NOUN
admet-929	201	8	binding	bind	VERB
admet-929	201	9	,	,	PUNCT
admet-929	201	10	albumin	albumin	NOUN
admet-929	201	11	and	and	CCONJ
admet-929	201	12	agp	agp	NOUN
admet-929	201	13	binding	binding	NOUN
admet-929	201	14	were	be	AUX
admet-929	201	15	also	also	ADV
admet-929	201	16	reported	report	VERB
admet-929	201	17	.	.	PUNCT
admet-929	202	1	the	the	DET
admet-929	202	2	human	human	ADJ
admet-929	202	3	plasma	plasma	NOUN
admet-929	202	4	protein	protein	NOUN
admet-929	202	5	binding	bind	VERB
admet-929	202	6	measurements	measurement	NOUN
admet-929	202	7	were	be	AUX
admet-929	202	8	repeated	repeat	VERB
admet-929	202	9	using	use	VERB
admet-929	202	10	the	the	DET
admet-929	202	11	rapid	rapid	ADJ
admet-929	202	12	equilibrium	equilibrium	NOUN
admet-929	202	13	dialysis	dialysis	NOUN
admet-929	202	14	method	method	NOUN
admet-929	202	15	and	and	CCONJ
admet-929	202	16	the	the	DET
admet-929	202	17	obtained	obtain	VERB
admet-929	202	18	average	average	ADJ
admet-929	202	19	values	value	NOUN
admet-929	202	20	were	be	AUX
admet-929	202	21	52.6	52.6	NUM
admet-929	202	22	%	%	NOUN
admet-929	202	23	(	(	PUNCT
admet-929	202	24	±6.2	±6.2	PROPN
admet-929	202	25	%	%	NOUN
admet-929	202	26	)	)	PUNCT
admet-929	202	27	and	and	CCONJ
admet-929	202	28	30.7	30.7	NUM
admet-929	202	29	%	%	NOUN
admet-929	202	30	(	(	PUNCT
admet-929	202	31	±11.3	±11.3	PROPN
admet-929	202	32	%	%	NOUN
admet-929	202	33	)	)	PUNCT
admet-929	202	34	for	for	ADP
admet-929	202	35	cq	cq	NOUN
admet-929	202	36	and	and	CCONJ
admet-929	202	37	hcq	hcq	NOUN
admet-929	202	38	,	,	PUNCT
admet-929	202	39	respectively	respectively	ADV
admet-929	202	40	.	.	PUNCT
admet-929	203	1	the	the	DET
admet-929	203	2	estimated	estimate	VERB
admet-929	203	3	plasma	plasma	NOUN
admet-929	203	4	protein	protein	NOUN
admet-929	203	5	binding	bind	VERB
admet-929	203	6	based	base	VERB
admet-929	203	7	on	on	ADP
admet-929	203	8	the	the	DET
admet-929	203	9	biomimetic	biomimetic	ADJ
admet-929	203	10	hplc	hplc	NOUN
admet-929	203	11	measurements	measurement	NOUN
admet-929	203	12	was	be	AUX
admet-929	203	13	much	much	ADV
admet-929	203	14	stronger	strong	ADJ
admet-929	203	15	(	(	PUNCT
admet-929	203	16	95	95	NUM
admet-929	203	17	%	%	NOUN
admet-929	203	18	and	and	CCONJ
admet-929	203	19	93	93	NUM
admet-929	203	20	%	%	NOUN
admet-929	203	21	for	for	ADP
admet-929	203	22	cq	cq	NOUN
admet-929	203	23	and	and	CCONJ
admet-929	203	24	hcq	hcq	NOUN
admet-929	203	25	,	,	PUNCT
admet-929	203	26	respectively	respectively	ADV
admet-929	203	27	)	)	PUNCT
admet-929	203	28	than	than	ADP
admet-929	203	29	that	that	PRON
admet-929	203	30	published	publish	VERB
admet-929	203	31	using	use	VERB
admet-929	203	32	in	in	ADP
admet-929	203	33	vivo	vivo	ADJ
admet-929	203	34	data	datum	NOUN
admet-929	203	35	.	.	PUNCT
admet-929	204	1	at	at	ADP
admet-929	204	2	this	this	DET
admet-929	204	3	stage	stage	NOUN
admet-929	204	4	,	,	PUNCT
admet-929	204	5	there	there	PRON
admet-929	204	6	is	be	VERB
admet-929	204	7	no	no	DET
admet-929	204	8	explanation	explanation	NOUN
admet-929	204	9	for	for	ADP
admet-929	204	10	the	the	DET
admet-929	204	11	difference	difference	NOUN
admet-929	204	12	.	.	PUNCT
admet-929	205	1	this	this	PRON
admet-929	205	2	is	be	AUX
admet-929	205	3	the	the	DET
admet-929	205	4	cause	cause	NOUN
admet-929	205	5	of	of	ADP
admet-929	205	6	the	the	DET
admet-929	205	7	much	much	ADV
admet-929	205	8	lower	low	ADJ
admet-929	205	9	estimated	estimate	VERB
admet-929	205	10	volume	volume	NOUN
admet-929	205	11	of	of	ADP
admet-929	205	12	distribution	distribution	NOUN
admet-929	205	13	.	.	PUNCT
admet-929	206	1	the	the	DET
admet-929	206	2	agp	agp	NOUN
admet-929	206	3	binding	binding	NOUN
admet-929	206	4	using	use	VERB
admet-929	206	5	equilibrium	equilibrium	NOUN
admet-929	206	6	dialysis	dialysis	NOUN
admet-929	206	7	method	method	NOUN
admet-929	206	8	was	be	AUX
admet-929	206	9	reported	report	VERB
admet-929	206	10	to	to	PART
admet-929	206	11	be	be	AUX
admet-929	206	12	48.4	48.4	NUM
admet-929	206	13	%	%	NOUN
admet-929	206	14	(	(	PUNCT
admet-929	206	15	59.9	59.9	NUM
admet-929	206	16	and	and	CCONJ
admet-929	206	17	34.9	34.9	NUM
admet-929	206	18	%	%	NOUN
admet-929	206	19	of	of	ADP
admet-929	206	20	the	the	DET
admet-929	206	21	r	r	NOUN
admet-929	206	22	and	and	CCONJ
admet-929	206	23	s	s	NOUN
admet-929	206	24	enantiomers	enantiomer	NOUN
admet-929	206	25	,	,	PUNCT
admet-929	206	26	respectively	respectively	ADV
admet-929	206	27	)	)	PUNCT
admet-929	206	28	for	for	ADP
admet-929	206	29	cq	cq	NOUN
admet-929	206	30	and	and	CCONJ
admet-929	206	31	34	34	NUM
admet-929	206	32	%	%	NOUN
admet-929	206	33	(	(	PUNCT
admet-929	206	34	29	29	NUM
admet-929	206	35	and	and	CCONJ
admet-929	206	36	41	41	NUM
admet-929	206	37	%	%	NOUN
admet-929	206	38	for	for	ADP
admet-929	206	39	the	the	DET
admet-929	206	40	r	r	NOUN
admet-929	206	41	and	and	CCONJ
admet-929	206	42	s	s	NOUN
admet-929	206	43	enantiomer	enantiomer	NOUN
admet-929	206	44	,	,	PUNCT
admet-929	206	45	respectively	respectively	ADV
admet-929	206	46	)	)	PUNCT
admet-929	206	47	for	for	ADP
admet-929	206	48	hcq	hcq	NOUN
admet-929	206	49	[	[	X
admet-929	206	50	51	51	NUM
admet-929	206	51	]	]	PUNCT
admet-929	206	52	.	.	PUNCT
admet-929	207	1	the	the	DET
admet-929	207	2	albumin	albumin	ADJ
admet-929	207	3	binding	binding	NOUN
admet-929	207	4	was	be	AUX
admet-929	207	5	only	only	ADV
admet-929	207	6	38.6	38.6	NUM
admet-929	207	7	and	and	CCONJ
admet-929	207	8	40	40	NUM
admet-929	207	9	%	%	NOUN
admet-929	207	10	for	for	ADP
admet-929	207	11	cq	cq	NOUN
admet-929	207	12	and	and	CCONJ
admet-929	207	13	hcq	hcq	NOUN
admet-929	207	14	,	,	PUNCT
admet-929	207	15	respectively	respectively	ADV
admet-929	207	16	,	,	PUNCT
admet-929	207	17	by	by	ADP
admet-929	207	18	the	the	DET
admet-929	207	19	same	same	ADJ
admet-929	207	20	author	author	NOUN
admet-929	207	21	[	[	X
admet-929	207	22	51	51	NUM
admet-929	207	23	]	]	PUNCT
admet-929	207	24	.	.	PUNCT
admet-929	208	1	these	these	DET
admet-929	208	2	values	value	NOUN
admet-929	208	3	were	be	AUX
admet-929	208	4	quoted	quote	VERB
admet-929	208	5	from	from	ADP
admet-929	208	6	earlier	early	ADJ
admet-929	208	7	publications	publication	NOUN
admet-929	208	8	where	where	SCONJ
admet-929	208	9	the	the	DET
admet-929	208	10	actual	actual	ADJ
admet-929	208	11	measurements	measurement	NOUN
admet-929	208	12	were	be	AUX
admet-929	208	13	originally	originally	ADV
admet-929	208	14	reported	report	VERB
admet-929	208	15	[	[	X
admet-929	208	16	52	52	NUM
admet-929	208	17	-	-	SYM
admet-929	208	18	54	54	NUM
admet-929	208	19	]	]	PUNCT
admet-929	208	20	.	.	PUNCT
admet-929	209	1	it	it	PRON
admet-929	209	2	was	be	AUX
admet-929	209	3	observed	observe	VERB
admet-929	209	4	that	that	SCONJ
admet-929	209	5	under	under	ADP
admet-929	209	6	the	the	DET
admet-929	209	7	standard	standard	PROPN
admet-929	209	8	ipa	ipa	PROPN
admet-929	209	9	gradient	gradient	PROPN
admet-929	209	10	conditions	condition	NOUN
admet-929	209	11	,	,	PUNCT
admet-929	209	12	both	both	PRON
admet-929	209	13	cq	cq	NOUN
admet-929	209	14	and	and	CCONJ
admet-929	209	15	hcq	hcq	NOUN
admet-929	209	16	eluted	elute	VERB
admet-929	209	17	between	between	ADP
admet-929	209	18	carbamazepine	carbamazepine	NOUN
admet-929	209	19	and	and	CCONJ
admet-929	209	20	nicardipine	nicardipine	NOUN
admet-929	209	21	,	,	PUNCT
admet-929	209	22	being	be	AUX
admet-929	209	23	closer	close	ADJ
admet-929	209	24	to	to	PART
admet-929	209	25	nicardipine	nicardipine	VERB
admet-929	209	26	,	,	PUNCT
admet-929	209	27	which	which	PRON
admet-929	209	28	binds	bind	VERB
admet-929	209	29	to	to	ADP
admet-929	209	30	plasma	plasma	NOUN
admet-929	209	31	proteins	protein	NOUN
admet-929	209	32	at	at	ADP
admet-929	209	33	75	75	NUM
admet-929	209	34	and	and	CCONJ
admet-929	209	35	95	95	NUM
admet-929	209	36	%	%	NOUN
admet-929	209	37	,	,	PUNCT
admet-929	209	38	respectively	respectively	ADV
admet-929	209	39	.	.	PUNCT
admet-929	210	1	this	this	PRON
admet-929	210	2	explains	explain	VERB
admet-929	210	3	why	why	SCONJ
admet-929	210	4	the	the	DET
admet-929	210	5	hsa	hsa	PROPN
admet-929	210	6	binding	bind	VERB
admet-929	210	7	was	be	AUX
admet-929	210	8	calculated	calculate	VERB
admet-929	210	9	as	as	ADP
admet-929	210	10	being	be	AUX
admet-929	210	11	87	87	NUM
admet-929	210	12	and	and	CCONJ
admet-929	210	13	83	83	NUM
admet-929	210	14	%	%	NOUN
admet-929	210	15	(	(	PUNCT
admet-929	210	16	see	see	VERB
admet-929	210	17	table	table	NOUN
admet-929	210	18	3	3	NUM
admet-929	210	19	)	)	PUNCT
admet-929	210	20	.	.	PUNCT
admet-929	211	1	the	the	DET
admet-929	211	2	demax	demax	NOUN
admet-929	211	3	values	value	NOUN
admet-929	211	4	reveal	reveal	VERB
admet-929	211	5	the	the	DET
admet-929	211	6	free	free	ADJ
admet-929	211	7	plasma	plasma	NOUN
admet-929	211	8	concentration	concentration	NOUN
admet-929	211	9	relative	relative	ADJ
admet-929	211	10	to	to	ADP
admet-929	211	11	the	the	DET
admet-929	211	12	dose	dose	NOUN
admet-929	211	13	.	.	PUNCT
admet-929	212	1	most	most	ADV
admet-929	212	2	marketed	market	VERB
admet-929	212	3	drug	drug	NOUN
admet-929	212	4	molecules	molecule	NOUN
admet-929	212	5	have	have	AUX
admet-929	212	6	demax	demax	NOUN
admet-929	212	7	values	value	NOUN
admet-929	212	8	of	of	ADP
admet-929	212	9	around	around	ADV
admet-929	212	10	1	1	NUM
admet-929	212	11	%	%	NOUN
admet-929	212	12	.	.	PUNCT
admet-929	213	1	it	it	PRON
admet-929	213	2	can	can	AUX
admet-929	213	3	be	be	AUX
admet-929	213	4	seen	see	VERB
admet-929	213	5	that	that	SCONJ
admet-929	213	6	both	both	PRON
admet-929	213	7	cq	cq	NOUN
admet-929	213	8	and	and	CCONJ
admet-929	213	9	hcq	hcq	NOUN
admet-929	213	10	have	have	VERB
admet-929	213	11	greater	great	ADJ
admet-929	213	12	than	than	ADP
admet-929	213	13	1	1	NUM
admet-929	213	14	%	%	NOUN
admet-929	213	15	drug	drug	NOUN
admet-929	213	16	efficiency	efficiency	NOUN
admet-929	213	17	,	,	PUNCT
admet-929	213	18	which	which	PRON
admet-929	213	19	indicates	indicate	VERB
admet-929	213	20	that	that	SCONJ
admet-929	213	21	a	a	DET
admet-929	213	22	high	high	ADJ
admet-929	213	23	free	free	ADJ
admet-929	213	24	concentration	concentration	NOUN
admet-929	213	25	can	can	AUX
admet-929	213	26	be	be	AUX
admet-929	213	27	achieved	achieve	VERB
admet-929	213	28	with	with	ADP
admet-929	213	29	a	a	DET
admet-929	213	30	relatively	relatively	ADV
admet-929	213	31	low	low	ADJ
admet-929	213	32	dose	dose	NOUN
admet-929	213	33	.	.	PUNCT
admet-929	214	1	the	the	DET
admet-929	214	2	estimated	estimate	VERB
admet-929	214	3	lung	lung	NOUN
admet-929	214	4	tissue	tissue	NOUN
admet-929	214	5	binding	bind	VERB
admet-929	214	6	for	for	ADP
admet-929	214	7	both	both	DET
admet-929	214	8	cq	cq	PROPN
admet-929	214	9	and	and	CCONJ
admet-929	214	10	hcq	hcq	NOUN
admet-929	214	11	was	be	AUX
admet-929	214	12	weaker	weak	ADJ
admet-929	214	13	than	than	ADP
admet-929	214	14	their	their	PRON
admet-929	214	15	brain	brain	NOUN
admet-929	214	16	tissue	tissue	NOUN
admet-929	214	17	binding	bind	VERB
admet-929	214	18	.	.	PUNCT
admet-929	215	1	as	as	SCONJ
admet-929	215	2	mucus	mucus	NOUN
admet-929	215	3	binding	binding	NOUN
admet-929	215	4	correlates	correlate	VERB
admet-929	215	5	very	very	ADV
admet-929	215	6	well	well	ADV
admet-929	215	7	with	with	SCONJ
admet-929	215	8	the	the	DET
admet-929	215	9	agp	agp	NOUN
admet-929	215	10	binding	bind	VERB
admet-929	215	11	,	,	PUNCT
admet-929	215	12	strong	strong	ADJ
admet-929	215	13	mucus	mucus	NOUN
admet-929	215	14	binding	bind	VERB
admet-929	215	15	can	can	AUX
admet-929	215	16	be	be	AUX
admet-929	215	17	expected	expect	VERB
admet-929	215	18	for	for	ADP
admet-929	215	19	both	both	DET
admet-929	215	20	compounds	compound	NOUN
admet-929	215	21	.	.	PUNCT
admet-929	216	1	the	the	DET
admet-929	216	2	cellular	cellular	ADJ
admet-929	216	3	partition	partition	NOUN
admet-929	216	4	coefficients	coefficient	NOUN
admet-929	216	5	of	of	ADP
admet-929	216	6	both	both	DET
admet-929	216	7	compounds	compound	NOUN
admet-929	216	8	are	be	AUX
admet-929	216	9	high	high	ADJ
admet-929	216	10	(	(	PUNCT
admet-929	216	11	kpcell	kpcell	ADJ
admet-929	216	12	above	above	ADP
admet-929	216	13	7	7	NUM
admet-929	216	14	)	)	PUNCT
admet-929	216	15	,	,	PUNCT
admet-929	216	16	which	which	PRON
admet-929	216	17	means	mean	VERB
admet-929	216	18	a	a	DET
admet-929	216	19	7	7	NUM
admet-929	216	20	to	to	PART
admet-929	216	21	8	8	NUM
admet-929	216	22	times	time	NOUN
admet-929	216	23	greater	great	ADJ
admet-929	216	24	concentration	concentration	NOUN
admet-929	216	25	than	than	SCONJ
admet-929	216	26	the	the	DET
admet-929	216	27	intracellular	intracellular	ADJ
admet-929	216	28	concentration	concentration	NOUN
admet-929	216	29	can	can	AUX
admet-929	216	30	be	be	AUX
admet-929	216	31	expected	expect	VERB
admet-929	216	32	for	for	ADP
admet-929	216	33	both	both	DET
admet-929	216	34	compounds	compound	NOUN
admet-929	216	35	.	.	PUNCT
admet-929	217	1	unfortunately	unfortunately	ADV
admet-929	217	2	,	,	PUNCT
admet-929	217	3	our	our	PRON
admet-929	217	4	standard	standard	ADJ
admet-929	217	5	fast	fast	ADJ
admet-929	217	6	gradient	gradient	ADJ
admet-929	217	7	protocols	protocol	NOUN
admet-929	217	8	used	use	VERB
admet-929	217	9	for	for	ADP
admet-929	217	10	the	the	DET
admet-929	217	11	hsa	hsa	PROPN
admet-929	217	12	and	and	CCONJ
admet-929	217	13	agp	agp	NOUN
admet-929	217	14	binding	bind	VERB
admet-929	217	15	measurements	measurement	NOUN
admet-929	217	16	did	do	AUX
admet-929	217	17	not	not	PART
admet-929	217	18	allow	allow	VERB
admet-929	217	19	the	the	DET
admet-929	217	20	separation	separation	NOUN
admet-929	217	21	of	of	ADP
admet-929	217	22	the	the	DET
admet-929	217	23	enantiomers	enantiomer	NOUN
admet-929	217	24	of	of	ADP
admet-929	217	25	cq	cq	NOUN
admet-929	217	26	or	or	CCONJ
admet-929	217	27	hcq	hcq	NOUN
admet-929	217	28	.	.	PUNCT
admet-929	218	1	this	this	PRON
admet-929	218	2	is	be	AUX
admet-929	218	3	also	also	ADV
admet-929	218	4	an	an	DET
admet-929	218	5	indication	indication	NOUN
admet-929	218	6	that	that	SCONJ
admet-929	218	7	there	there	PRON
admet-929	218	8	are	be	VERB
admet-929	218	9	no	no	DET
admet-929	218	10	significant	significant	ADJ
admet-929	218	11	differences	difference	NOUN
admet-929	218	12	in	in	ADP
admet-929	218	13	the	the	DET
admet-929	218	14	biomimetic	biomimetic	ADJ
admet-929	218	15	properties	property	NOUN
admet-929	218	16	of	of	ADP
admet-929	218	17	each	each	DET
admet-929	218	18	respective	respective	ADJ
admet-929	218	19	enantiomer	enantiomer	NOUN
admet-929	218	20	.	.	PUNCT
admet-929	219	1	therefore	therefore	ADV
admet-929	219	2	,	,	PUNCT
admet-929	219	3	new	new	ADJ
admet-929	219	4	hplc	hplc	NOUN
admet-929	219	5	property	property	NOUN
admet-929	219	6	cq	cq	PROPN
admet-929	219	7	hcq	hcq	PROPN
admet-929	219	8	phospholipidotic	phospholipidotic	PROPN
admet-929	219	9	potential	potential	NOUN
admet-929	219	10	(	(	PUNCT
admet-929	219	11	cad	cad	NOUN
admet-929	219	12	-	-	PUNCT
admet-929	219	13	likeness	likeness	NOUN
admet-929	219	14	)	)	PUNCT
admet-929	219	15	82.8	82.8	NUM
admet-929	219	16	73.6	73.6	NUM
admet-929	219	17	%	%	NOUN
admet-929	219	18	btb	btb	ADP
admet-929	219	19	98.4	98.4	NUM
admet-929	219	20	97.6	97.6	NUM
admet-929	219	21	est	est	NOUN
admet-929	219	22	log	log	NOUN
admet-929	219	23	k	k	PROPN
admet-929	219	24	bb	bb	NOUN
admet-929	219	25	0.9	0.9	NUM
admet-929	219	26	0.8	0.8	NUM
admet-929	219	27	brain	brain	NOUN
admet-929	219	28	to	to	PART
admet-929	219	29	plasma	plasma	VERB
admet-929	219	30	3.4	3.4	NUM
admet-929	219	31	2.8	2.8	NUM
admet-929	219	32	vd	vd	NOUN
admet-929	219	33	(	(	PUNCT
admet-929	219	34	l	l	NOUN
admet-929	219	35	/	/	SYM
admet-929	219	36	kg	kg	NOUN
admet-929	219	37	)	)	PUNCT
admet-929	219	38	6.9	6.9	NUM
admet-929	219	39	5.1	5.1	NUM
admet-929	219	40	vdu	vdu	NOUN
admet-929	219	41	(	(	PUNCT
admet-929	219	42	l	l	NOUN
admet-929	219	43	/	/	SYM
admet-929	219	44	kg	kg	NOUN
admet-929	219	45	)	)	PUNCT
admet-929	219	46	56.1	56.1	NUM
admet-929	219	47	38.8	38.8	NUM
admet-929	219	48	demax%	demax%	NUM
admet-929	219	49	1.8	1.8	NUM
admet-929	219	50	2.6	2.6	NUM
admet-929	219	51	%	%	NOUN
admet-929	219	52	ltb	ltb	PROPN
admet-929	219	53	96.3	96.3	NUM
admet-929	219	54	93.9	93.9	NUM
admet-929	219	55	kpcell	kpcell	NOUN
admet-929	219	56	8.7	8.7	NUM
admet-929	219	57	7.3	7.3	NUM
admet-929	219	58	admet	admet	NOUN
admet-929	219	59	&	&	CCONJ
admet-929	219	60	dmpk	dmpk	PROPN
admet-929	219	61	9(2	9(2	NUM
admet-929	219	62	)	)	PUNCT
admet-929	219	63	(	(	PUNCT
admet-929	219	64	2021	2021	NUM
admet-929	219	65	)	)	PUNCT
admet-929	219	66	151	151	NUM
admet-929	219	67	-	-	SYM
admet-929	219	68	165	165	NUM
admet-929	219	69	biomimetic	biomimetic	ADJ
admet-929	219	70	properties	property	NOUN
admet-929	219	71	of	of	ADP
admet-929	219	72	chlorquine	chlorquine	NOUN
admet-929	219	73	enantiomers	enantiomer	NOUN
admet-929	219	74	doi	doi	NOUN
admet-929	219	75	:	:	PUNCT
admet-929	219	76	https://doi.org/10.5599/admet.929	https://doi.org/10.5599/admet.929	NOUN
admet-929	219	77	159	159	NUM
admet-929	219	78	conditions	condition	NOUN
admet-929	219	79	were	be	AUX
admet-929	219	80	evaluated	evaluate	VERB
admet-929	219	81	on	on	ADP
admet-929	219	82	the	the	DET
admet-929	219	83	chiralpak	chiralpak	NOUN
admet-929	219	84	hsa	hsa	PROPN
admet-929	219	85	and	and	CCONJ
admet-929	219	86	chiralpak	chiralpak	VERB
admet-929	219	87	agp	agp	PROPN
admet-929	219	88	column	column	NOUN
admet-929	219	89	by	by	ADP
admet-929	219	90	increasing	increase	VERB
admet-929	219	91	the	the	DET
admet-929	219	92	gradient	gradient	ADJ
admet-929	219	93	analysis	analysis	NOUN
admet-929	219	94	time	time	NOUN
admet-929	219	95	and	and	CCONJ
admet-929	219	96	reducing	reduce	VERB
admet-929	219	97	the	the	DET
admet-929	219	98	maximum	maximum	PROPN
admet-929	219	99	ipa	ipa	PROPN
admet-929	219	100	concentration	concentration	NOUN
admet-929	219	101	in	in	ADP
admet-929	219	102	the	the	DET
admet-929	219	103	mobile	mobile	ADJ
admet-929	219	104	phase	phase	NOUN
admet-929	219	105	.	.	PUNCT
admet-929	220	1	slowing	slow	VERB
admet-929	220	2	down	down	ADP
admet-929	220	3	the	the	DET
admet-929	220	4	gradient	gradient	NOUN
admet-929	220	5	to	to	PART
admet-929	220	6	reach	reach	VERB
admet-929	220	7	10	10	NUM
admet-929	220	8	and	and	CCONJ
admet-929	220	9	20	20	NUM
admet-929	220	10	%	%	NOUN
admet-929	220	11	ipa	ipa	PROPN
admet-929	220	12	did	do	AUX
admet-929	220	13	not	not	PART
admet-929	220	14	result	result	VERB
admet-929	220	15	in	in	ADP
admet-929	220	16	the	the	DET
admet-929	220	17	separation	separation	NOUN
admet-929	220	18	of	of	ADP
admet-929	220	19	the	the	DET
admet-929	220	20	enantiomers	enantiomer	NOUN
admet-929	220	21	on	on	ADP
admet-929	220	22	the	the	DET
admet-929	220	23	hsa	hsa	PROPN
admet-929	220	24	column	column	NOUN
admet-929	220	25	,	,	PUNCT
admet-929	220	26	and	and	CCONJ
admet-929	220	27	both	both	PRON
admet-929	220	28	cq	cq	NOUN
admet-929	220	29	and	and	CCONJ
admet-929	220	30	hcq	hcq	PROPN
admet-929	220	31	eluted	elute	VERB
admet-929	220	32	after	after	ADP
admet-929	220	33	carbamazepine	carbamazepine	NOUN
admet-929	220	34	(	(	PUNCT
admet-929	220	35	75	75	NUM
admet-929	220	36	%	%	NOUN
admet-929	220	37	plasma	plasma	NOUN
admet-929	220	38	protein	protein	NOUN
admet-929	220	39	binding	bind	VERB
admet-929	220	40	)	)	PUNCT
admet-929	220	41	.	.	PUNCT
admet-929	221	1	the	the	DET
admet-929	221	2	calculated	calculate	VERB
admet-929	221	3	hsa	hsa	PROPN
admet-929	221	4	binding	bind	VERB
admet-929	221	5	was	be	AUX
admet-929	221	6	82.2	82.2	NUM
admet-929	221	7	and	and	CCONJ
admet-929	221	8	81.9	81.9	NUM
admet-929	221	9	%	%	NOUN
admet-929	221	10	for	for	ADP
admet-929	221	11	cq	cq	NOUN
admet-929	221	12	and	and	CCONJ
admet-929	221	13	hcq	hcq	NOUN
admet-929	221	14	,	,	PUNCT
admet-929	221	15	respectively	respectively	ADV
admet-929	221	16	.	.	PUNCT
admet-929	222	1	isocratic	isocratic	ADJ
admet-929	222	2	measurements	measurement	NOUN
admet-929	222	3	using	use	VERB
admet-929	222	4	5	5	NUM
admet-929	222	5	,	,	PUNCT
admet-929	222	6	8	8	NUM
admet-929	222	7	and	and	CCONJ
admet-929	222	8	15	15	NUM
admet-929	222	9	%	%	NOUN
admet-929	222	10	ipa	ipa	NOUN
admet-929	222	11	in	in	ADP
admet-929	222	12	the	the	DET
admet-929	222	13	mobile	mobile	ADJ
admet-929	222	14	phase	phase	NOUN
admet-929	222	15	resulted	result	VERB
admet-929	222	16	in	in	ADP
admet-929	222	17	80	80	NUM
admet-929	222	18	%	%	NOUN
admet-929	222	19	binding	bind	VERB
admet-929	222	20	when	when	SCONJ
admet-929	222	21	the	the	DET
admet-929	222	22	relative	relative	ADJ
admet-929	222	23	retention	retention	NOUN
admet-929	222	24	times	time	NOUN
admet-929	222	25	obtained	obtain	VERB
admet-929	222	26	using	use	VERB
admet-929	222	27	a	a	DET
admet-929	222	28	partial	partial	ADJ
admet-929	222	29	set	set	NOUN
admet-929	222	30	of	of	ADP
admet-929	222	31	calibration	calibration	NOUN
admet-929	222	32	compounds	compound	NOUN
admet-929	222	33	were	be	AUX
admet-929	222	34	taken	take	VERB
admet-929	222	35	into	into	ADP
admet-929	222	36	consideration	consideration	NOUN
admet-929	222	37	.	.	PUNCT
admet-929	223	1	no	no	DET
admet-929	223	2	separation	separation	NOUN
admet-929	223	3	of	of	ADP
admet-929	223	4	the	the	DET
admet-929	223	5	enantiomers	enantiomer	NOUN
admet-929	223	6	was	be	AUX
admet-929	223	7	observed	observe	VERB
admet-929	223	8	.	.	PUNCT
admet-929	224	1	figure	figure	NOUN
admet-929	224	2	3	3	NUM
admet-929	224	3	shows	show	VERB
admet-929	224	4	the	the	DET
admet-929	224	5	chromatograms	chromatogram	NOUN
admet-929	224	6	of	of	ADP
admet-929	224	7	cq	cq	NOUN
admet-929	224	8	and	and	CCONJ
admet-929	224	9	hcq	hcq	PROPN
admet-929	224	10	obtained	obtain	VERB
admet-929	224	11	on	on	ADP
admet-929	224	12	a	a	DET
admet-929	224	13	chiralpak	chiralpak	ADJ
admet-929	224	14	hsa	hsa	PROPN
admet-929	224	15	column	column	NOUN
admet-929	224	16	using	use	VERB
admet-929	224	17	%	%	PROPN
admet-929	224	18	ipa	ipa	PROPN
admet-929	224	19	in	in	ADP
admet-929	224	20	isocratic	isocratic	ADJ
admet-929	224	21	mode	mode	NOUN
admet-929	224	22	.	.	PUNCT
admet-929	225	1	however	however	ADV
admet-929	225	2	,	,	PUNCT
admet-929	225	3	no	no	DET
admet-929	225	4	separation	separation	NOUN
admet-929	225	5	of	of	ADP
admet-929	225	6	enantiomers	enantiomer	NOUN
admet-929	225	7	was	be	AUX
admet-929	225	8	observed	observe	VERB
admet-929	225	9	.	.	PUNCT
admet-929	226	1	figure	figure	VERB
admet-929	226	2	3	3	NUM
admet-929	226	3	.	.	PUNCT
admet-929	227	1	the	the	DET
admet-929	227	2	chromatograms	chromatogram	NOUN
admet-929	227	3	of	of	ADP
admet-929	227	4	cq	cq	PROPN
admet-929	227	5	(	(	PUNCT
admet-929	227	6	a	a	NOUN
admet-929	227	7	)	)	PUNCT
admet-929	227	8	and	and	CCONJ
admet-929	227	9	hcq	hcq	NOUN
admet-929	227	10	(	(	PUNCT
admet-929	227	11	b	b	NOUN
admet-929	227	12	)	)	PUNCT
admet-929	227	13	on	on	ADP
admet-929	227	14	chiralpak	chiralpak	PROPN
admet-929	227	15	hsa	hsa	PROPN
admet-929	227	16	column	column	NOUN
admet-929	227	17	using	use	VERB
admet-929	227	18	0	0	NUM
admet-929	227	19	%	%	NOUN
admet-929	227	20	ipa	ipa	PROPN
admet-929	227	21	in	in	ADP
admet-929	227	22	the	the	DET
admet-929	227	23	mobile	mobile	ADJ
admet-929	227	24	phase	phase	NOUN
admet-929	227	25	in	in	ADP
admet-929	227	26	isocratic	isocratic	ADJ
admet-929	227	27	mode	mode	NOUN
admet-929	227	28	.	.	PUNCT
admet-929	228	1	when	when	SCONJ
admet-929	228	2	similar	similar	ADJ
admet-929	228	3	changes	change	NOUN
admet-929	228	4	in	in	ADP
admet-929	228	5	the	the	DET
admet-929	228	6	mobile	mobile	ADJ
admet-929	228	7	phases	phase	NOUN
admet-929	228	8	were	be	AUX
admet-929	228	9	applied	apply	VERB
admet-929	228	10	using	use	VERB
admet-929	228	11	the	the	DET
admet-929	228	12	chiralpak	chiralpak	NOUN
admet-929	228	13	agp	agp	PROPN
admet-929	228	14	column	column	NOUN
admet-929	228	15	,	,	PUNCT
admet-929	228	16	excellent	excellent	ADJ
admet-929	228	17	separations	separation	NOUN
admet-929	228	18	of	of	ADP
admet-929	228	19	both	both	CCONJ
admet-929	228	20	the	the	DET
admet-929	228	21	cq	cq	NOUN
admet-929	228	22	and	and	CCONJ
admet-929	228	23	hcq	hcq	NOUN
admet-929	228	24	enantiomers	enantiomer	NOUN
admet-929	228	25	were	be	AUX
admet-929	228	26	observed	observe	VERB
admet-929	228	27	albeit	albeit	SCONJ
admet-929	228	28	with	with	ADP
admet-929	228	29	a	a	DET
admet-929	228	30	very	very	ADV
admet-929	228	31	short	short	ADJ
admet-929	228	32	column	column	NOUN
admet-929	228	33	size	size	NOUN
admet-929	228	34	(	(	PUNCT
admet-929	228	35	l=50	l=50	PROPN
admet-929	228	36	mm	mm	NOUN
admet-929	228	37	)	)	PUNCT
admet-929	228	38	and	and	CCONJ
admet-929	228	39	fast	fast	ADJ
admet-929	228	40	flow	flow	NOUN
admet-929	228	41	rate	rate	NOUN
admet-929	228	42	(	(	PUNCT
admet-929	228	43	1.2	1.2	NUM
admet-929	228	44	ml	ml	NOUN
admet-929	228	45	/	/	SYM
admet-929	228	46	min	min	NOUN
admet-929	228	47	)	)	PUNCT
admet-929	228	48	.	.	PUNCT
admet-929	229	1	it	it	PRON
admet-929	229	2	can	can	AUX
admet-929	229	3	be	be	AUX
admet-929	229	4	seen	see	VERB
admet-929	229	5	in	in	ADP
admet-929	229	6	figure	figure	NOUN
admet-929	229	7	4	4	NUM
admet-929	229	8	that	that	SCONJ
admet-929	229	9	the	the	DET
admet-929	229	10	separation	separation	NOUN
admet-929	229	11	of	of	ADP
admet-929	229	12	enantiomers	enantiomer	NOUN
admet-929	229	13	occurred	occur	VERB
admet-929	229	14	under	under	ADP
admet-929	229	15	the	the	DET
admet-929	229	16	shallower	shallower	NOUN
admet-929	229	17	gradient	gradient	ADJ
admet-929	229	18	conditions	condition	NOUN
admet-929	229	19	.	.	PUNCT
admet-929	230	1	still	still	ADV
admet-929	230	2	,	,	PUNCT
admet-929	230	3	no	no	DET
admet-929	230	4	significant	significant	ADJ
admet-929	230	5	differences	difference	NOUN
admet-929	230	6	between	between	ADP
admet-929	230	7	the	the	DET
admet-929	230	8	retention	retention	NOUN
admet-929	230	9	times	time	NOUN
admet-929	230	10	were	be	AUX
admet-929	230	11	observed	observe	VERB
admet-929	230	12	for	for	ADP
admet-929	230	13	cq	cq	NOUN
admet-929	230	14	and	and	CCONJ
admet-929	230	15	hcq	hcq	NOUN
admet-929	230	16	confirming	confirm	VERB
admet-929	230	17	that	that	SCONJ
admet-929	230	18	the	the	DET
admet-929	230	19	agp	agp	NOUN
admet-929	230	20	binding	binding	NOUN
admet-929	230	21	of	of	ADP
admet-929	230	22	the	the	DET
admet-929	230	23	two	two	NUM
admet-929	230	24	molecules	molecule	NOUN
admet-929	230	25	is	be	AUX
admet-929	230	26	quite	quite	ADV
admet-929	230	27	similar	similar	ADJ
admet-929	230	28	.	.	PUNCT
admet-929	231	1	the	the	DET
admet-929	231	2	chiral	chiral	ADJ
admet-929	231	3	separations	separation	NOUN
admet-929	231	4	were	be	AUX
admet-929	231	5	also	also	ADV
admet-929	231	6	obtained	obtain	VERB
admet-929	231	7	in	in	ADP
admet-929	231	8	the	the	DET
admet-929	231	9	isocratic	isocratic	ADJ
admet-929	231	10	mode	mode	NOUN
admet-929	231	11	.	.	PUNCT
admet-929	232	1	however	however	ADV
admet-929	232	2	,	,	PUNCT
admet-929	232	3	the	the	DET
admet-929	232	4	difference	difference	NOUN
admet-929	232	5	in	in	ADP
admet-929	232	6	binding	bind	VERB
admet-929	232	7	between	between	ADP
admet-929	232	8	the	the	DET
admet-929	232	9	enantiomers	enantiomer	NOUN
admet-929	232	10	was	be	AUX
admet-929	232	11	only	only	ADV
admet-929	232	12	3	3	NUM
admet-929	232	13	to	to	PART
admet-929	232	14	4	4	NUM
admet-929	232	15	%	%	NOUN
admet-929	232	16	.	.	PUNCT
admet-929	233	1	based	base	VERB
admet-929	233	2	on	on	ADP
admet-929	233	3	these	these	DET
admet-929	233	4	measurements	measurement	NOUN
admet-929	233	5	,	,	PUNCT
admet-929	233	6	the	the	DET
admet-929	233	7	agp	agp	NOUN
admet-929	233	8	binding	binding	NOUN
admet-929	233	9	is	be	AUX
admet-929	233	10	much	much	ADV
admet-929	233	11	stronger	strong	ADJ
admet-929	233	12	for	for	ADP
admet-929	233	13	both	both	DET
admet-929	233	14	cq	cq	NOUN
admet-929	233	15	and	and	CCONJ
admet-929	233	16	hcq	hcq	NOUN
admet-929	233	17	than	than	SCONJ
admet-929	233	18	previously	previously	ADV
admet-929	233	19	reported	report	VERB
admet-929	233	20	.	.	PUNCT
admet-929	234	1	when	when	SCONJ
admet-929	234	2	the	the	DET
admet-929	234	3	agp	agp	NOUN
admet-929	234	4	binding	binding	NOUN
admet-929	234	5	is	be	AUX
admet-929	234	6	above	above	ADP
admet-929	234	7	80	80	NUM
admet-929	234	8	%	%	NOUN
admet-929	234	9	,	,	PUNCT
admet-929	234	10	the	the	DET
admet-929	234	11	compounds	compound	NOUN
admet-929	234	12	are	be	AUX
admet-929	234	13	expected	expect	VERB
admet-929	234	14	to	to	PART
admet-929	234	15	have	have	VERB
admet-929	234	16	variable	variable	ADJ
admet-929	234	17	efficacy	efficacy	NOUN
admet-929	234	18	in	in	ADP
admet-929	234	19	the	the	DET
admet-929	234	20	clinic	clinic	NOUN
admet-929	234	21	.	.	PUNCT
admet-929	235	1	it	it	PRON
admet-929	235	2	is	be	AUX
admet-929	235	3	because	because	SCONJ
admet-929	235	4	the	the	DET
admet-929	235	5	agp	agp	NOUN
admet-929	235	6	concentration	concentration	NOUN
admet-929	235	7	changes	change	NOUN
admet-929	235	8	in	in	ADP
admet-929	235	9	various	various	ADJ
admet-929	235	10	disease	disease	NOUN
admet-929	235	11	states	state	NOUN
admet-929	235	12	and	and	CCONJ
admet-929	235	13	it	it	PRON
admet-929	235	14	can	can	AUX
admet-929	235	15	alter	alter	VERB
admet-929	235	16	the	the	DET
admet-929	235	17	total	total	ADJ
admet-929	235	18	plasma	plasma	NOUN
admet-929	235	19	protein	protein	NOUN
admet-929	235	20	binding	bind	VERB
admet-929	235	21	significantly	significantly	ADV
admet-929	235	22	,	,	PUNCT
admet-929	235	23	and	and	CCONJ
admet-929	235	24	that	that	PRON
admet-929	235	25	may	may	AUX
admet-929	235	26	cause	cause	VERB
admet-929	235	27	a	a	DET
admet-929	235	28	reduction	reduction	NOUN
admet-929	235	29	of	of	ADP
admet-929	235	30	the	the	DET
admet-929	235	31	free	free	ADJ
admet-929	235	32	therapeutic	therapeutic	ADJ
admet-929	235	33	concentration	concentration	NOUN
admet-929	235	34	of	of	ADP
admet-929	235	35	the	the	DET
admet-929	235	36	drugs	drug	NOUN
admet-929	235	37	.	.	PUNCT
admet-929	236	1	figure	figure	VERB
admet-929	236	2	4	4	NUM
admet-929	236	3	.	.	PUNCT
admet-929	237	1	the	the	DET
admet-929	237	2	chromatogram	chromatogram	NOUN
admet-929	237	3	of	of	ADP
admet-929	237	4	racemic	racemic	ADJ
admet-929	237	5	chloroquine	chloroquine	NOUN
admet-929	237	6	(	(	PUNCT
admet-929	237	7	cq	cq	NOUN
admet-929	237	8	)	)	PUNCT
admet-929	237	9	(	(	PUNCT
admet-929	237	10	a	a	X
admet-929	237	11	)	)	PUNCT
admet-929	237	12	and	and	CCONJ
admet-929	237	13	hydroxychloroquine	hydroxychloroquine	PROPN
admet-929	237	14	(	(	PUNCT
admet-929	237	15	hcq	hcq	PROPN
admet-929	237	16	)	)	PUNCT
admet-929	237	17	(	(	PUNCT
admet-929	237	18	b	b	X
admet-929	237	19	)	)	PUNCT
admet-929	237	20	obtained	obtain	VERB
admet-929	237	21	using	use	VERB
admet-929	237	22	the	the	DET
admet-929	237	23	shallower	shallower	NOUN
admet-929	237	24	gradient	gradient	NOUN
admet-929	237	25	method	method	NOUN
admet-929	237	26	(	(	PUNCT
admet-929	237	27	“	"	PUNCT
admet-929	237	28	slow	slow	ADJ
admet-929	237	29	gradient	gradient	NOUN
admet-929	237	30	”	"	PUNCT
admet-929	237	31	)	)	PUNCT
admet-929	237	32	with	with	ADP
admet-929	237	33	0	0	NUM
admet-929	237	34	to	to	PART
admet-929	237	35	15	15	NUM
admet-929	237	36	%	%	NOUN
admet-929	237	37	ipa	ipa	NOUN
admet-929	237	38	over	over	ADP
admet-929	237	39	4.0	4.0	NUM
admet-929	237	40	min	min	NOUN
admet-929	237	41	and	and	CCONJ
admet-929	237	42	then	then	ADV
admet-929	237	43	maintained	maintain	VERB
admet-929	237	44	at	at	ADP
admet-929	237	45	15	15	NUM
admet-929	237	46	%	%	NOUN
admet-929	237	47	for	for	ADP
admet-929	237	48	1	1	NUM
admet-929	237	49	min	min	NOUN
admet-929	237	50	before	before	ADP
admet-929	237	51	returning	return	VERB
admet-929	237	52	to	to	ADP
admet-929	237	53	0	0	NUM
admet-929	237	54	%	%	NOUN
admet-929	237	55	ipa	ipa	PROPN
admet-929	237	56	on	on	ADP
admet-929	237	57	a	a	DET
admet-929	237	58	chiralpak	chiralpak	NOUN
admet-929	237	59	agp	agp	PROPN
admet-929	237	60	column	column	NOUN
admet-929	237	61	(	(	PUNCT
admet-929	237	62	50	50	NUM
admet-929	237	63	x	x	SYM
admet-929	237	64	3	3	NUM
admet-929	237	65	mm	mm	NOUN
admet-929	237	66	)	)	PUNCT
admet-929	237	67	with	with	ADP
admet-929	237	68	a	a	DET
admet-929	237	69	1.2	1.2	NUM
admet-929	237	70	ml	ml	NOUN
admet-929	237	71	/	/	SYM
admet-929	237	72	min	min	NOUN
admet-929	237	73	flow	flow	NOUN
admet-929	237	74	rate	rate	NOUN
admet-929	237	75	.	.	PUNCT
admet-929	238	1	the	the	DET
admet-929	238	2	enantiomers	enantiomer	NOUN
admet-929	238	3	are	be	AUX
admet-929	238	4	identified	identify	VERB
admet-929	238	5	based	base	VERB
admet-929	238	6	on	on	ADP
admet-929	238	7	ref	ref	NOUN
admet-929	239	1	[	[	X
admet-929	239	2	51	51	NUM
admet-929	239	3	]	]	PUNCT
admet-929	239	4	that	that	PRON
admet-929	239	5	reported	report	VERB
admet-929	239	6	cq	cq	PROPN
admet-929	239	7	(	(	PUNCT
admet-929	239	8	r	r	NOUN
admet-929	239	9	)	)	PUNCT
admet-929	239	10	and	and	CCONJ
admet-929	239	11	hcq	hcq	NOUN
admet-929	239	12	(	(	PUNCT
admet-929	239	13	s	s	NOUN
admet-929	239	14	)	)	PUNCT
admet-929	239	15	as	as	ADP
admet-929	239	16	the	the	DET
admet-929	239	17	stronger	strong	ADJ
admet-929	239	18	binders	binder	NOUN
admet-929	239	19	to	to	ADP
admet-929	239	20	agp	agp	PROPN
admet-929	239	21	.	.	PUNCT
admet-929	240	1	(	(	PUNCT
admet-929	240	2	a	a	X
admet-929	240	3	)	)	PUNCT
admet-929	240	4	(	(	PUNCT
admet-929	240	5	b	b	X
admet-929	240	6	)	)	PUNCT
admet-929	240	7	(	(	PUNCT
admet-929	240	8	a	a	X
admet-929	240	9	)	)	PUNCT
admet-929	240	10	(	(	PUNCT
admet-929	240	11	b	b	X
admet-929	240	12	)	)	PUNCT
admet-929	240	13	https://doi.org/10.5599/admet.929	https://doi.org/10.5599/admet.929	NOUN
admet-929	240	14	klara	klara	PROPN
admet-929	240	15	valko	valko	PROPN
admet-929	240	16	and	and	CCONJ
admet-929	240	17	tong	tong	PROPN
admet-929	240	18	zhang	zhang	PROPN
admet-929	240	19	admet	admet	PROPN
admet-929	240	20	&	&	CCONJ
admet-929	240	21	dmpk	dmpk	PROPN
admet-929	240	22	9(2	9(2	NUM
admet-929	240	23	)	)	PUNCT
admet-929	240	24	(	(	PUNCT
admet-929	240	25	2021	2021	NUM
admet-929	240	26	)	)	PUNCT
admet-929	240	27	151	151	NUM
admet-929	240	28	-	-	SYM
admet-929	240	29	165	165	NUM
admet-929	240	30	160	160	NUM
admet-929	240	31	table	table	NOUN
admet-929	240	32	7	7	NUM
admet-929	240	33	shows	show	VERB
admet-929	240	34	the	the	DET
admet-929	240	35	%	%	NOUN
admet-929	240	36	binding	bind	VERB
admet-929	240	37	data	datum	NOUN
admet-929	240	38	obtained	obtain	VERB
admet-929	240	39	using	use	VERB
admet-929	240	40	a	a	DET
admet-929	240	41	slow	slow	ADJ
admet-929	240	42	gradient	gradient	NOUN
admet-929	240	43	(	(	PUNCT
admet-929	240	44	up	up	ADP
admet-929	240	45	to	to	PART
admet-929	240	46	15	15	NUM
admet-929	240	47	%	%	NOUN
admet-929	240	48	ipa	ipa	PROPN
admet-929	240	49	)	)	PUNCT
admet-929	240	50	.	.	PUNCT
admet-929	241	1	the	the	DET
admet-929	241	2	protein	protein	NOUN
admet-929	241	3	binding	bind	VERB
admet-929	241	4	measurements	measurement	NOUN
admet-929	241	5	were	be	AUX
admet-929	241	6	repeated	repeat	VERB
admet-929	241	7	using	use	VERB
admet-929	241	8	isocratic	isocratic	ADJ
admet-929	241	9	conditions	condition	NOUN
admet-929	241	10	with	with	ADP
admet-929	241	11	5	5	NUM
admet-929	241	12	,	,	PUNCT
admet-929	241	13	8	8	NUM
admet-929	241	14	and	and	CCONJ
admet-929	241	15	15	15	NUM
admet-929	241	16	%	%	NOUN
admet-929	241	17	ipa	ipa	NOUN
admet-929	241	18	in	in	ADP
admet-929	241	19	the	the	DET
admet-929	241	20	mobile	mobile	ADJ
admet-929	241	21	phase	phase	NOUN
admet-929	241	22	.	.	PUNCT
admet-929	242	1	under	under	ADP
admet-929	242	2	such	such	ADJ
admet-929	242	3	conditions	condition	NOUN
admet-929	242	4	,	,	PUNCT
admet-929	242	5	stronger	strong	ADJ
admet-929	242	6	binding	binding	ADJ
admet-929	242	7	compounds	compound	NOUN
admet-929	242	8	from	from	ADP
admet-929	242	9	the	the	DET
admet-929	242	10	calibration	calibration	NOUN
admet-929	242	11	mixture	mixture	NOUN
admet-929	242	12	(	(	PUNCT
admet-929	242	13	warfarin	warfarin	NOUN
admet-929	242	14	,	,	PUNCT
admet-929	242	15	indomethacin	indomethacin	NOUN
admet-929	242	16	and	and	CCONJ
admet-929	242	17	diclofenac	diclofenac	NOUN
admet-929	242	18	)	)	PUNCT
admet-929	242	19	could	could	AUX
admet-929	242	20	not	not	PART
admet-929	242	21	be	be	AUX
admet-929	242	22	eluted	elute	VERB
admet-929	242	23	.	.	PUNCT
admet-929	243	1	the	the	DET
admet-929	243	2	retention	retention	NOUN
admet-929	243	3	times	time	NOUN
admet-929	243	4	of	of	ADP
admet-929	243	5	cq	cq	PROPN
admet-929	243	6	and	and	CCONJ
admet-929	243	7	hcq	hcq	NOUN
admet-929	243	8	obtained	obtain	VERB
admet-929	243	9	when	when	SCONJ
admet-929	243	10	using	use	VERB
admet-929	243	11	5	5	NUM
admet-929	243	12	,	,	PUNCT
admet-929	243	13	8	8	NUM
admet-929	243	14	and	and	CCONJ
admet-929	243	15	15	15	NUM
admet-929	243	16	%	%	NOUN
admet-929	243	17	ipa	ipa	PROPN
admet-929	243	18	on	on	ADP
admet-929	243	19	chiralpak	chiralpak	PROPN
admet-929	243	20	hsa	hsa	PROPN
admet-929	243	21	and	and	CCONJ
admet-929	243	22	chiralpak	chiralpak	VERB
admet-929	243	23	agp	agp	PROPN
admet-929	243	24	columns	column	NOUN
admet-929	243	25	are	be	AUX
admet-929	243	26	listed	list	VERB
admet-929	243	27	in	in	ADP
admet-929	243	28	table	table	NOUN
admet-929	243	29	8	8	NUM
admet-929	243	30	.	.	PUNCT
admet-929	243	31	table	table	NOUN
admet-929	243	32	7	7	NUM
admet-929	243	33	.	.	PUNCT
admet-929	244	1	the	the	DET
admet-929	244	2	measured	measure	VERB
admet-929	244	3	and	and	CCONJ
admet-929	244	4	estimated	estimate	VERB
admet-929	244	5	biomimetic	biomimetic	ADJ
admet-929	244	6	properties	property	NOUN
admet-929	244	7	of	of	ADP
admet-929	244	8	cq	cq	NOUN
admet-929	244	9	and	and	CCONJ
admet-929	244	10	hcq	hcq	NOUN
admet-929	244	11	based	base	VERB
admet-929	244	12	on	on	ADP
admet-929	244	13	the	the	DET
admet-929	244	14	data	datum	NOUN
admet-929	244	15	obtained	obtain	VERB
admet-929	244	16	using	use	VERB
admet-929	244	17	the	the	DET
admet-929	244	18	slower	slow	ADJ
admet-929	244	19	and	and	CCONJ
admet-929	244	20	shallower	shallower	NOUN
admet-929	244	21	gradient	gradient	NOUN
admet-929	244	22	(	(	PUNCT
admet-929	244	23	up	up	ADP
admet-929	244	24	to	to	PART
admet-929	244	25	15	15	NUM
admet-929	244	26	%	%	NOUN
admet-929	244	27	ipa	ipa	PROPN
admet-929	244	28	)	)	PUNCT
admet-929	244	29	.	.	PUNCT
admet-929	245	1	property	property	NOUN
admet-929	245	2	(	(	PUNCT
admet-929	245	3	+	+	NOUN
admet-929	245	4	)	)	PUNCT
admet-929	245	5	-s	-s	PROPN
admet-929	246	1	cq	cq	NOUN
admet-929	246	2	(	(	PUNCT
admet-929	246	3	-)-r	-)-r	INTJ
admet-929	246	4	cq	cq	INTJ
admet-929	246	5	(	(	PUNCT
admet-929	246	6	+	+	NOUN
admet-929	246	7	)	)	PUNCT
admet-929	246	8	-s	-s	PROPN
admet-929	246	9	hcq	hcq	NOUN
admet-929	246	10	(	(	PUNCT
admet-929	246	11	-)-r	-)-r	INTJ
admet-929	246	12	hcq	hcq	NOUN
admet-929	246	13	%	%	NOUN
admet-929	246	14	bound	bind	VERB
admet-929	246	15	hsa	hsa	PROPN
admet-929	246	16	82.2	82.2	NUM
admet-929	246	17	82.2	82.2	NUM
admet-929	246	18	81.9	81.9	NUM
admet-929	246	19	81.9	81.9	NUM
admet-929	246	20	%	%	NOUN
admet-929	246	21	bound	bind	VERB
admet-929	246	22	agp	agp	NOUN
admet-929	246	23	85.0	85.0	NUM
admet-929	246	24	88.4	88.4	NUM
admet-929	246	25	88.5	88.5	NUM
admet-929	246	26	84.3	84.3	NUM
admet-929	246	27	calc%ppb	calc%ppb	NOUN
admet-929	246	28	90.6	90.6	NUM
admet-929	246	29	91.1	91.1	NUM
admet-929	246	30	91.2	91.2	NUM
admet-929	246	31	91.7	91.7	NUM
admet-929	246	32	chi	chi	NOUN
admet-929	246	33	log	log	NOUN
admet-929	246	34	d2	d2	PROPN
admet-929	246	35	-1.2	-1.2	PROPN
admet-929	246	36	-1.2	-1.2	PROPN
admet-929	246	37	-1.3	-1.3	PROPN
admet-929	246	38	-1.3	-1.3	PROPN
admet-929	246	39	chi	chi	PROPN
admet-929	246	40	log	log	NOUN
admet-929	246	41	d7.4	d7.4	NOUN
admet-929	246	42	0.8	0.8	NUM
admet-929	246	43	0.8	0.8	NUM
admet-929	246	44	0.7	0.7	NUM
admet-929	246	45	0.7	0.7	NUM
admet-929	246	46	chi	chi	NOUN
admet-929	246	47	log	log	NOUN
admet-929	246	48	d10.5	d10.5	X
admet-929	246	49	2.7	2.7	NUM
admet-929	246	50	2.7	2.7	NUM
admet-929	246	51	2.1	2.1	NUM
admet-929	246	52	2.1	2.1	NUM
admet-929	246	53	chilog	chilog	NOUN
admet-929	246	54	p	p	NOUN
admet-929	246	55	2.7	2.7	NUM
admet-929	246	56	2.7	2.7	NUM
admet-929	246	57	2.1	2.1	NUM
admet-929	246	58	2.1	2.1	NUM
admet-929	246	59	chi	chi	NOUN
admet-929	246	60	iam	iam	PROPN
admet-929	246	61	46.9	46.9	NUM
admet-929	246	62	46.9	46.9	NUM
admet-929	246	63	45.4	45.4	NUM
admet-929	246	64	45.4	45.4	NUM
admet-929	246	65	cad	cad	NOUN
admet-929	246	66	-	-	PUNCT
admet-929	246	67	likeness	likeness	NOUN
admet-929	246	68	82.9	82.9	NUM
admet-929	246	69	82.9	82.9	NUM
admet-929	246	70	73.6	73.6	NUM
admet-929	246	71	7367	7367	NUM
admet-929	246	72	%	%	NOUN
admet-929	246	73	btb	btb	ADP
admet-929	246	74	97.6	97.6	NUM
admet-929	246	75	97.6	97.6	NUM
admet-929	246	76	97.1	97.1	NUM
admet-929	246	77	97.0	97.0	NUM
admet-929	246	78	est	est	X
admet-929	246	79	log	log	NOUN
admet-929	247	1	k	k	PROPN
admet-929	247	2	bb	bb	NOUN
admet-929	247	3	0.9	0.9	NUM
admet-929	247	4	0.9	0.9	NUM
admet-929	247	5	0.9	0.9	NUM
admet-929	247	6	0.8	0.8	NUM
admet-929	247	7	brain	brain	NOUN
admet-929	247	8	to	to	PART
admet-929	247	9	plasma	plasma	VERB
admet-929	247	10	4.0	4.0	NUM
admet-929	247	11	3.8	3.8	NUM
admet-929	247	12	3.0	3.0	NUM
admet-929	247	13	2.8	2.8	NUM
admet-929	247	14	vd	vd	NOUN
admet-929	247	15	l	l	X
admet-929	247	16	/	/	SYM
admet-929	247	17	kg	kg	PROPN
admet-929	248	1	8.2	8.2	NUM
admet-929	248	2	8.2	8.2	NUM
admet-929	248	3	6.4	6.4	NUM
admet-929	248	4	6.3	6.3	NUM
admet-929	248	5	vdu	vdu	PROPN
admet-929	248	6	45.7	45.7	NUM
admet-929	248	7	45.8	45.8	NUM
admet-929	248	8	35.3	35.3	NUM
admet-929	248	9	35.1	35.1	NUM
admet-929	248	10	demax%	demax%	NUM
admet-929	248	11	2.2	2.2	NUM
admet-929	248	12	2.2	2.2	NUM
admet-929	248	13	2.8	2.8	NUM
admet-929	248	14	2.9	2.9	NUM
admet-929	248	15	%	%	NOUN
admet-929	248	16	lung	lung	NOUN
admet-929	248	17	tissue	tissue	NOUN
admet-929	248	18	binding	bind	VERB
admet-929	248	19	95.5	95.5	NUM
admet-929	248	20	95.6	95.6	NUM
admet-929	248	21	93.1	93.1	NUM
admet-929	248	22	93.3	93.3	NUM
admet-929	248	23	table	table	NOUN
admet-929	248	24	8	8	NUM
admet-929	248	25	.	.	PUNCT
admet-929	249	1	the	the	DET
admet-929	249	2	retention	retention	NOUN
admet-929	249	3	times	time	NOUN
admet-929	249	4	obtained	obtain	VERB
admet-929	249	5	for	for	ADP
admet-929	249	6	cq	cq	PROPN
admet-929	249	7	and	and	CCONJ
admet-929	249	8	hcq	hcq	NOUN
admet-929	249	9	(	(	PUNCT
admet-929	249	10	enantiomers	enantiomer	NOUN
admet-929	249	11	)	)	PUNCT
admet-929	249	12	using	use	VERB
admet-929	249	13	a	a	DET
admet-929	249	14	1.2	1.2	NUM
admet-929	249	15	ml	ml	NOUN
admet-929	249	16	/	/	SYM
admet-929	249	17	min	min	NOUN
admet-929	249	18	flow	flow	NOUN
admet-929	249	19	rate	rate	NOUN
admet-929	249	20	and	and	CCONJ
admet-929	249	21	5	5	NUM
admet-929	249	22	,	,	PUNCT
admet-929	249	23	8	8	NUM
admet-929	249	24	and	and	CCONJ
admet-929	249	25	15	15	NUM
admet-929	249	26	%	%	NOUN
admet-929	249	27	ipa	ipa	PROPN
admet-929	249	28	on	on	ADP
admet-929	249	29	chiralpak	chiralpak	PROPN
admet-929	249	30	hsa	hsa	PROPN
admet-929	249	31	and	and	CCONJ
admet-929	249	32	chiralpak	chiralpak	VERB
admet-929	249	33	agp	agp	NOUN
admet-929	249	34	columns	column	NOUN
admet-929	249	35	.	.	PUNCT
admet-929	250	1	the	the	DET
admet-929	250	2	calculated	calculated	ADJ
admet-929	250	3	%	%	NOUN
admet-929	250	4	binding	bind	VERB
admet-929	250	5	data	datum	NOUN
admet-929	250	6	are	be	AUX
admet-929	250	7	also	also	ADV
admet-929	250	8	given	give	VERB
admet-929	250	9	in	in	ADP
admet-929	250	10	brackets	bracket	NOUN
admet-929	250	11	.	.	PUNCT
admet-929	251	1	the	the	DET
admet-929	251	2	retention	retention	NOUN
admet-929	251	3	times	time	NOUN
admet-929	251	4	of	of	ADP
admet-929	251	5	propranolol	propranolol	PROPN
admet-929	251	6	and	and	CCONJ
admet-929	251	7	nicardipine	nicardipine	NOUN
admet-929	251	8	,	,	PUNCT
admet-929	251	9	the	the	DET
admet-929	251	10	two	two	NUM
admet-929	251	11	basic	basic	ADJ
admet-929	251	12	compounds	compound	NOUN
admet-929	251	13	from	from	ADP
admet-929	251	14	the	the	DET
admet-929	251	15	calibration	calibration	NOUN
admet-929	251	16	set	set	NOUN
admet-929	251	17	,	,	PUNCT
admet-929	251	18	are	be	AUX
admet-929	251	19	also	also	ADV
admet-929	251	20	shown	show	VERB
admet-929	251	21	.	.	PUNCT
admet-929	252	1	the	the	DET
admet-929	252	2	last	last	ADJ
admet-929	252	3	two	two	NUM
admet-929	252	4	rows	row	NOUN
admet-929	252	5	in	in	ADP
admet-929	252	6	the	the	DET
admet-929	252	7	table	table	NOUN
admet-929	252	8	are	be	AUX
admet-929	252	9	the	the	DET
admet-929	252	10	data	datum	NOUN
admet-929	252	11	from	from	ADP
admet-929	252	12	reference	reference	NOUN
admet-929	252	13	[	[	X
admet-929	252	14	51	51	NUM
admet-929	252	15	]	]	PUNCT
admet-929	252	16	where	where	SCONJ
admet-929	252	17	the	the	DET
admet-929	252	18	values	value	NOUN
admet-929	252	19	were	be	AUX
admet-929	252	20	obtained	obtain	VERB
admet-929	252	21	using	use	VERB
admet-929	252	22	an	an	DET
admet-929	252	23	equilibrium	equilibrium	NOUN
admet-929	252	24	dialysis	dialysis	NOUN
admet-929	252	25	method	method	NOUN
admet-929	252	26	(	(	PUNCT
admet-929	252	27	n	n	CCONJ
admet-929	252	28	/	/	SYM
admet-929	252	29	a	a	DET
admet-929	252	30	means	mean	NOUN
admet-929	252	31	not	not	PART
admet-929	252	32	applicable	applicable	ADJ
admet-929	252	33	)	)	PUNCT
admet-929	252	34	compound	compound	NOUN
admet-929	252	35	/	/	SYM
admet-929	252	36	cond	cond	NOUN
admet-929	252	37	.	.	PUNCT
admet-929	253	1	cq	cq	NOUN
admet-929	254	1	(	(	PUNCT
admet-929	254	2	r	r	NOUN
admet-929	254	3	)	)	PUNCT
admet-929	254	4	cq	cq	NOUN
admet-929	254	5	(	(	PUNCT
admet-929	254	6	s	s	NOUN
admet-929	254	7	)	)	PUNCT
admet-929	254	8	hcq	hcq	NOUN
admet-929	254	9	(	(	PUNCT
admet-929	254	10	r	r	NOUN
admet-929	254	11	)	)	PUNCT
admet-929	254	12	hcq	hcq	NOUN
admet-929	254	13	(	(	PUNCT
admet-929	254	14	s	s	NOUN
admet-929	254	15	)	)	PUNCT
admet-929	254	16	propranolol	propranolol	NOUN
admet-929	254	17	(	(	PUNCT
admet-929	254	18	66	66	NUM
admet-929	254	19	%	%	NOUN
admet-929	254	20	ppb	ppb	NOUN
admet-929	254	21	)	)	PUNCT
admet-929	254	22	nicardipine	nicardipine	NOUN
admet-929	254	23	(	(	PUNCT
admet-929	254	24	96	96	NUM
admet-929	254	25	%	%	NOUN
admet-929	254	26	ppb	ppb	NOUN
admet-929	254	27	)	)	PUNCT
admet-929	254	28	hsa	hsa	PROPN
admet-929	254	29	5	5	NUM
admet-929	254	30	%	%	NOUN
admet-929	254	31	ipa	ipa	PROPN
admet-929	254	32	(	(	PUNCT
admet-929	254	33	min	min	PROPN
admet-929	254	34	)	)	PUNCT
admet-929	254	35	0.89	0.89	NUM
admet-929	254	36	(	(	PUNCT
admet-929	254	37	60	60	NUM
admet-929	254	38	%	%	NOUN
admet-929	254	39	)	)	PUNCT
admet-929	254	40	1.15	1.15	NUM
admet-929	254	41	(	(	PUNCT
admet-929	254	42	68	68	NUM
admet-929	254	43	%	%	NOUN
admet-929	254	44	)	)	PUNCT
admet-929	254	45	0.94	0.94	NUM
admet-929	254	46	(	(	PUNCT
admet-929	254	47	61	61	NUM
admet-929	254	48	%	%	NOUN
admet-929	254	49	)	)	PUNCT
admet-929	254	50	1.4	1.4	NUM
admet-929	254	51	(	(	PUNCT
admet-929	254	52	73	73	NUM
admet-929	254	53	%	%	NOUN
admet-929	254	54	)	)	PUNCT
admet-929	254	55	0.76	0.76	NUM
admet-929	254	56	(	(	PUNCT
admet-929	254	57	54	54	NUM
admet-929	254	58	%	%	NOUN
admet-929	254	59	)	)	PUNCT
admet-929	254	60	6	6	NUM
admet-929	254	61	(	(	PUNCT
admet-929	254	62	96	96	NUM
admet-929	254	63	%	%	NOUN
admet-929	254	64	)	)	PUNCT
admet-929	254	65	hsa	hsa	PROPN
admet-929	255	1	8	8	NUM
admet-929	255	2	%	%	NOUN
admet-929	255	3	ipa	ipa	PROPN
admet-929	255	4	(	(	PUNCT
admet-929	255	5	min	min	PROPN
admet-929	255	6	)	)	PUNCT
admet-929	255	7	0.87	0.87	NUM
admet-929	255	8	(	(	PUNCT
admet-929	255	9	64	64	NUM
admet-929	255	10	%	%	NOUN
admet-929	255	11	)	)	PUNCT
admet-929	255	12	0.87	0.87	NUM
admet-929	255	13	(	(	PUNCT
admet-929	255	14	64	64	NUM
admet-929	255	15	%	%	NOUN
admet-929	255	16	)	)	PUNCT
admet-929	255	17	0.91	0.91	NUM
admet-929	255	18	(	(	PUNCT
admet-929	255	19	66	66	NUM
admet-929	255	20	%	%	NOUN
admet-929	255	21	)	)	PUNCT
admet-929	255	22	0.91	0.91	NUM
admet-929	255	23	(	(	PUNCT
admet-929	255	24	66	66	NUM
admet-929	255	25	%	%	NOUN
admet-929	255	26	)	)	PUNCT
admet-929	255	27	0.73	0.73	NUM
admet-929	255	28	(	(	PUNCT
admet-929	255	29	57.6	57.6	NUM
admet-929	255	30	%	%	NOUN
admet-929	255	31	)	)	PUNCT
admet-929	255	32	3.39	3.39	NUM
admet-929	255	33	(	(	PUNCT
admet-929	255	34	95	95	NUM
admet-929	255	35	%	%	NOUN
admet-929	255	36	)	)	PUNCT
admet-929	255	37	hsa	hsa	PROPN
admet-929	255	38	15	15	NUM
admet-929	255	39	%	%	NOUN
admet-929	255	40	ipa	ipa	PROPN
admet-929	255	41	(	(	PUNCT
admet-929	255	42	min	min	PROPN
admet-929	255	43	)	)	PUNCT
admet-929	255	44	0.68	0.68	NUM
admet-929	255	45	(	(	PUNCT
admet-929	255	46	80	80	NUM
admet-929	255	47	%	%	NOUN
admet-929	255	48	)	)	PUNCT
admet-929	255	49	0.68	0.68	NUM
admet-929	255	50	(	(	PUNCT
admet-929	255	51	80	80	NUM
admet-929	255	52	%	%	NOUN
admet-929	255	53	)	)	PUNCT
admet-929	255	54	0.69	0.69	NUM
admet-929	255	55	(	(	PUNCT
admet-929	255	56	80	80	NUM
admet-929	255	57	%	%	NOUN
admet-929	255	58	)	)	PUNCT
admet-929	255	59	0.69	0.69	NUM
admet-929	255	60	(	(	PUNCT
admet-929	255	61	80	80	NUM
admet-929	255	62	%	%	NOUN
admet-929	255	63	)	)	PUNCT
admet-929	255	64	0.58	0.58	NUM
admet-929	255	65	(	(	PUNCT
admet-929	255	66	66	66	NUM
admet-929	255	67	%	%	NOUN
admet-929	255	68	)	)	PUNCT
admet-929	255	69	1.05	1.05	NUM
admet-929	255	70	(	(	PUNCT
admet-929	255	71	95	95	NUM
admet-929	255	72	%	%	NOUN
admet-929	255	73	)	)	PUNCT
admet-929	255	74	agp	agp	NOUN
admet-929	255	75	5	5	NUM
admet-929	255	76	%	%	NOUN
admet-929	255	77	ipa	ipa	PROPN
admet-929	255	78	(	(	PUNCT
admet-929	255	79	min	min	PROPN
admet-929	255	80	)	)	PUNCT
admet-929	255	81	3.84	3.84	NUM
admet-929	255	82	(	(	PUNCT
admet-929	255	83	86	86	NUM
admet-929	255	84	%	%	NOUN
admet-929	255	85	)	)	PUNCT
admet-929	255	86	5.24	5.24	NUM
admet-929	255	87	(	(	PUNCT
admet-929	255	88	90	90	NUM
admet-929	255	89	%	%	NOUN
admet-929	255	90	)	)	PUNCT
admet-929	255	91	3.84	3.84	NUM
admet-929	255	92	(	(	PUNCT
admet-929	255	93	86	86	NUM
admet-929	255	94	%	%	NOUN
admet-929	255	95	)	)	PUNCT
admet-929	255	96	5.4	5.4	NUM
admet-929	255	97	(	(	PUNCT
admet-929	255	98	90	90	NUM
admet-929	255	99	%	%	NOUN
admet-929	255	100	)	)	PUNCT
admet-929	255	101	2.78	2.78	NUM
admet-929	255	102	(	(	PUNCT
admet-929	255	103	85	85	NUM
admet-929	255	104	%	%	NOUN
admet-929	255	105	)	)	PUNCT
admet-929	255	106	>	>	SYM
admet-929	255	107	8	8	NUM
admet-929	255	108	min	min	NOUN
admet-929	255	109	(	(	PUNCT
admet-929	255	110	>	>	SYM
admet-929	255	111	98	98	NUM
admet-929	255	112	%	%	NOUN
admet-929	255	113	)	)	PUNCT
admet-929	256	1	agp	agp	NOUN
admet-929	256	2	8	8	NUM
admet-929	256	3	%	%	NOUN
admet-929	256	4	ipa	ipa	PROPN
admet-929	256	5	(	(	PUNCT
admet-929	256	6	min	min	PROPN
admet-929	256	7	)	)	PUNCT
admet-929	256	8	2.53	2.53	NUM
admet-929	256	9	(	(	PUNCT
admet-929	256	10	84	84	NUM
admet-929	256	11	%	%	NOUN
admet-929	256	12	)	)	PUNCT
admet-929	256	13	2.55	2.55	NUM
admet-929	256	14	(	(	PUNCT
admet-929	256	15	84	84	NUM
admet-929	256	16	%	%	NOUN
admet-929	256	17	)	)	PUNCT
admet-929	256	18	2.95	2.95	NUM
admet-929	256	19	(	(	PUNCT
admet-929	256	20	85	85	NUM
admet-929	256	21	%	%	NOUN
admet-929	256	22	)	)	PUNCT
admet-929	256	23	3.85	3.85	NUM
admet-929	256	24	(	(	PUNCT
admet-929	256	25	87	87	NUM
admet-929	256	26	%	%	NOUN
admet-929	256	27	)	)	PUNCT
admet-929	256	28	1.73	1.73	NUM
admet-929	256	29	(	(	PUNCT
admet-929	256	30	68	68	NUM
admet-929	256	31	%	%	NOUN
admet-929	256	32	)	)	PUNCT
admet-929	256	33	5.63	5.63	NUM
admet-929	256	34	(	(	PUNCT
admet-929	256	35	98	98	NUM
admet-929	256	36	%	%	NOUN
admet-929	256	37	)	)	PUNCT
admet-929	256	38	agp	agp	NOUN
admet-929	256	39	15	15	NUM
admet-929	256	40	%	%	NOUN
admet-929	256	41	ipa	ipa	PROPN
admet-929	256	42	(	(	PUNCT
admet-929	256	43	min	min	PROPN
admet-929	256	44	)	)	PUNCT
admet-929	256	45	2.20	2.20	NUM
admet-929	256	46	(	(	PUNCT
admet-929	256	47	82	82	NUM
admet-929	256	48	%	%	NOUN
admet-929	256	49	)	)	PUNCT
admet-929	256	50	2.00	2.00	NUM
admet-929	256	51	(	(	PUNCT
admet-929	256	52	81	81	NUM
admet-929	256	53	%	%	NOUN
admet-929	256	54	)	)	PUNCT
admet-929	256	55	1.98	1.98	NUM
admet-929	256	56	(	(	PUNCT
admet-929	256	57	81	81	NUM
admet-929	256	58	%	%	NOUN
admet-929	256	59	)	)	PUNCT
admet-929	256	60	2.23	2.23	NUM
admet-929	256	61	(	(	PUNCT
admet-929	256	62	83	83	NUM
admet-929	256	63	%	%	NOUN
admet-929	256	64	)	)	PUNCT
admet-929	256	65	1.58	1.58	NUM
admet-929	256	66	(	(	PUNCT
admet-929	256	67	67	67	NUM
admet-929	256	68	%	%	NOUN
admet-929	256	69	)	)	PUNCT
admet-929	256	70	5.0	5.0	NUM
admet-929	256	71	(	(	PUNCT
admet-929	256	72	96	96	NUM
admet-929	256	73	%	%	NOUN
admet-929	256	74	)	)	PUNCT
admet-929	257	1	%	%	INTJ
admet-929	258	1	hsa	hsa	NOUN
admet-929	258	2	bound	bind	VERB
admet-929	258	3	[	[	PUNCT
admet-929	258	4	51	51	NUM
admet-929	258	5	]	]	SYM
admet-929	258	6	30	30	NUM
admet-929	258	7	%	%	NOUN
admet-929	258	8	54	54	NUM
admet-929	258	9	%	%	NOUN
admet-929	258	10	50	50	NUM
admet-929	258	11	%	%	NOUN
admet-929	258	12	29	29	NUM
admet-929	258	13	%	%	NOUN
admet-929	258	14	n	n	CCONJ
admet-929	258	15	/	/	SYM
admet-929	258	16	a	a	DET
admet-929	258	17	n//a	n//a	PROPN
admet-929	258	18	%	%	NOUN
admet-929	258	19	agp	agp	NOUN
admet-929	258	20	bound	bind	VERB
admet-929	258	21	[	[	PUNCT
admet-929	258	22	51	51	NUM
admet-929	258	23	]	]	SYM
admet-929	258	24	59	59	NUM
admet-929	258	25	%	%	NOUN
admet-929	258	26	35	35	NUM
admet-929	258	27	%	%	NOUN
admet-929	258	28	29	29	NUM
admet-929	258	29	%	%	NOUN
admet-929	258	30	34	34	NUM
admet-929	258	31	%	%	NOUN
admet-929	258	32	n	n	CCONJ
admet-929	258	33	/	/	SYM
admet-929	258	34	a	a	DET
admet-929	258	35	n	n	CCONJ
admet-929	258	36	/	/	SYM
admet-929	258	37	a	a	PRON
admet-929	258	38	it	it	PRON
admet-929	258	39	can	can	AUX
admet-929	258	40	be	be	AUX
admet-929	258	41	seen	see	VERB
admet-929	258	42	in	in	ADP
admet-929	258	43	table	table	NOUN
admet-929	258	44	8	8	NUM
admet-929	258	45	that	that	SCONJ
admet-929	258	46	the	the	DET
admet-929	258	47	estimated	estimate	VERB
admet-929	258	48	%	%	NOUN
admet-929	258	49	binding	bind	VERB
admet-929	258	50	data	datum	NOUN
admet-929	258	51	using	use	VERB
admet-929	258	52	the	the	DET
admet-929	258	53	retention	retention	NOUN
admet-929	258	54	time	time	NOUN
admet-929	258	55	measured	measure	VERB
admet-929	258	56	for	for	ADP
admet-929	258	57	the	the	DET
admet-929	258	58	partial	partial	ADJ
admet-929	258	59	calibration	calibration	NOUN
admet-929	258	60	set	set	NOUN
admet-929	258	61	of	of	ADP
admet-929	258	62	compounds	compound	NOUN
admet-929	258	63	changes	change	NOUN
admet-929	258	64	depending	depend	VERB
admet-929	258	65	on	on	ADP
admet-929	258	66	the	the	DET
admet-929	258	67	experimental	experimental	ADJ
admet-929	258	68	conditions	condition	NOUN
admet-929	258	69	.	.	PUNCT
admet-929	259	1	the	the	DET
admet-929	259	2	hsa	hsa	PROPN
admet-929	259	3	binding	binding	NOUN
admet-929	259	4	ranged	range	VERB
admet-929	259	5	from	from	ADP
admet-929	259	6	60	60	NUM
admet-929	259	7	to	to	PART
admet-929	259	8	80	80	NUM
admet-929	259	9	%	%	NOUN
admet-929	259	10	but	but	CCONJ
admet-929	259	11	generally	generally	ADV
admet-929	259	12	was	be	AUX
admet-929	259	13	much	much	ADV
admet-929	259	14	greater	great	ADJ
admet-929	259	15	than	than	ADP
admet-929	259	16	the	the	DET
admet-929	259	17	published	publish	VERB
admet-929	259	18	albumin	albumin	NOUN
admet-929	259	19	(	(	PUNCT
admet-929	259	20	hsa	hsa	PROPN
admet-929	259	21	)	)	PUNCT
admet-929	259	22	and	and	CCONJ
admet-929	259	23	alpha-1	alpha-1	NOUN
admet-929	259	24	-	-	PUNCT
admet-929	259	25	acid	acid	NOUN
admet-929	259	26	glycoprotein	glycoprotein	NOUN
admet-929	259	27	(	(	PUNCT
admet-929	259	28	agp	agp	NOUN
admet-929	259	29	)	)	PUNCT
admet-929	259	30	binding	bind	VERB
admet-929	259	31	data	datum	NOUN
admet-929	259	32	.	.	PUNCT
admet-929	260	1	this	this	PRON
admet-929	260	2	is	be	AUX
admet-929	260	3	because	because	SCONJ
admet-929	260	4	the	the	DET
admet-929	260	5	retention	retention	NOUN
admet-929	260	6	times	time	NOUN
admet-929	260	7	dependency	dependency	NOUN
admet-929	260	8	on	on	ADP
admet-929	260	9	the	the	DET
admet-929	260	10	ipa	ipa	PROPN
admet-929	260	11	concentration	concentration	NOUN
admet-929	260	12	was	be	AUX
admet-929	260	13	greater	great	ADJ
admet-929	260	14	for	for	ADP
admet-929	260	15	the	the	DET
admet-929	260	16	calibration	calibration	NOUN
admet-929	260	17	set	set	NOUN
admet-929	260	18	of	of	ADP
admet-929	260	19	compounds	compound	NOUN
admet-929	260	20	than	than	ADP
admet-929	260	21	for	for	ADP
admet-929	260	22	the	the	DET
admet-929	260	23	cq	cq	NOUN
admet-929	260	24	and	and	CCONJ
admet-929	260	25	hcq	hcq	NOUN
admet-929	260	26	.	.	PUNCT
admet-929	261	1	table	table	NOUN
admet-929	261	2	9	9	NUM
admet-929	261	3	shows	show	VERB
admet-929	261	4	the	the	DET
admet-929	261	5	measured	measure	VERB
admet-929	261	6	admet	admet	PROPN
admet-929	261	7	&	&	CCONJ
admet-929	261	8	dmpk	dmpk	PROPN
admet-929	261	9	9(2	9(2	NUM
admet-929	261	10	)	)	PUNCT
admet-929	261	11	(	(	PUNCT
admet-929	261	12	2021	2021	NUM
admet-929	261	13	)	)	PUNCT
admet-929	261	14	151	151	NUM
admet-929	261	15	-	-	SYM
admet-929	261	16	165	165	NUM
admet-929	261	17	biomimetic	biomimetic	ADJ
admet-929	261	18	properties	property	NOUN
admet-929	261	19	of	of	ADP
admet-929	261	20	chlorquine	chlorquine	NOUN
admet-929	261	21	enantiomers	enantiomer	NOUN
admet-929	261	22	doi	doi	NOUN
admet-929	261	23	:	:	PUNCT
admet-929	261	24	https://doi.org/10.5599/admet.929	https://doi.org/10.5599/admet.929	NOUN
admet-929	261	25	161	161	NUM
admet-929	261	26	and	and	CCONJ
admet-929	261	27	estimated	estimate	VERB
admet-929	261	28	biomimetic	biomimetic	ADJ
admet-929	261	29	properties	property	NOUN
admet-929	261	30	of	of	ADP
admet-929	261	31	cq	cq	NOUN
admet-929	261	32	and	and	CCONJ
admet-929	261	33	hcq	hcq	NOUN
admet-929	261	34	based	base	VERB
admet-929	261	35	on	on	ADP
admet-929	261	36	the	the	DET
admet-929	261	37	data	datum	NOUN
admet-929	261	38	obtained	obtain	VERB
admet-929	261	39	when	when	SCONJ
admet-929	261	40	using	use	VERB
admet-929	261	41	the	the	DET
admet-929	261	42	isocratic	isocratic	ADJ
admet-929	261	43	method	method	NOUN
admet-929	261	44	on	on	ADP
admet-929	261	45	the	the	DET
admet-929	261	46	chiralpak	chiralpak	NOUN
admet-929	261	47	hsa	hsa	PROPN
admet-929	261	48	and	and	CCONJ
admet-929	261	49	chiralpak	chiralpak	VERB
admet-929	261	50	agp	agp	PROPN
admet-929	261	51	column	column	NOUN
admet-929	261	52	(	(	PUNCT
admet-929	261	53	ipa	ipa	PROPN
admet-929	261	54	concentration	concentration	NOUN
admet-929	261	55	15	15	NUM
admet-929	261	56	%	%	NOUN
admet-929	261	57	)	)	PUNCT
admet-929	261	58	.	.	PUNCT
admet-929	262	1	probably	probably	ADV
admet-929	262	2	,	,	PUNCT
admet-929	262	3	cq	cq	PROPN
admet-929	262	4	and	and	CCONJ
admet-929	262	5	hcq	hcq	PROPN
admet-929	262	6	do	do	AUX
admet-929	262	7	not	not	PART
admet-929	262	8	bind	bind	VERB
admet-929	262	9	to	to	ADP
admet-929	262	10	the	the	DET
admet-929	262	11	hydrophobic	hydrophobic	NOUN
admet-929	262	12	site	site	NOUN
admet-929	262	13	on	on	ADP
admet-929	262	14	the	the	DET
admet-929	262	15	albumin	albumin	NOUN
admet-929	262	16	but	but	CCONJ
admet-929	262	17	could	could	AUX
admet-929	262	18	bind	bind	VERB
admet-929	262	19	to	to	ADP
admet-929	262	20	a	a	DET
admet-929	262	21	specific	specific	ADJ
admet-929	262	22	area	area	NOUN
admet-929	262	23	that	that	PRON
admet-929	262	24	is	be	AUX
admet-929	262	25	not	not	PART
admet-929	262	26	affected	affect	VERB
admet-929	262	27	strongly	strongly	ADV
admet-929	262	28	by	by	ADP
admet-929	262	29	the	the	DET
admet-929	262	30	ipa	ipa	PROPN
admet-929	262	31	concentration	concentration	NOUN
admet-929	262	32	.	.	PUNCT
admet-929	263	1	the	the	DET
admet-929	263	2	agp	agp	NOUN
admet-929	263	3	binding	binding	NOUN
admet-929	263	4	was	be	AUX
admet-929	263	5	also	also	ADV
admet-929	263	6	much	much	ADV
admet-929	263	7	stronger	strong	ADJ
admet-929	263	8	using	use	VERB
admet-929	263	9	the	the	DET
admet-929	263	10	biomimetic	biomimetic	ADJ
admet-929	263	11	methodology	methodology	NOUN
admet-929	263	12	that	that	PRON
admet-929	263	13	converts	convert	VERB
admet-929	263	14	the	the	DET
admet-929	263	15	%	%	NOUN
admet-929	263	16	binding	bind	VERB
admet-929	263	17	to	to	ADP
admet-929	263	18	the	the	DET
admet-929	263	19	total	total	ADJ
admet-929	263	20	plasma	plasma	NOUN
admet-929	263	21	protein	protein	NOUN
admet-929	263	22	concentration	concentration	NOUN
admet-929	263	23	where	where	SCONJ
admet-929	263	24	the	the	DET
admet-929	263	25	agp	agp	NOUN
admet-929	263	26	concentration	concentration	NOUN
admet-929	263	27	is	be	AUX
admet-929	263	28	only	only	ADV
admet-929	263	29	1	1	NUM
admet-929	263	30	to	to	PART
admet-929	263	31	3	3	NUM
admet-929	263	32	%	%	NOUN
admet-929	263	33	.	.	PUNCT
admet-929	264	1	the	the	DET
admet-929	264	2	difference	difference	NOUN
admet-929	264	3	can	can	AUX
admet-929	264	4	be	be	AUX
admet-929	264	5	explained	explain	VERB
admet-929	264	6	by	by	ADP
admet-929	264	7	the	the	DET
admet-929	264	8	different	different	ADJ
admet-929	264	9	scaling	scaling	NOUN
admet-929	264	10	used	use	VERB
admet-929	264	11	when	when	SCONJ
admet-929	264	12	expressing	express	VERB
admet-929	264	13	the	the	DET
admet-929	264	14	%	%	NOUN
admet-929	264	15	of	of	ADP
admet-929	264	16	the	the	DET
admet-929	264	17	compound	compound	NOUN
admet-929	264	18	bound	bind	VERB
admet-929	264	19	in	in	ADP
admet-929	264	20	plasma	plasma	NOUN
admet-929	264	21	or	or	CCONJ
admet-929	264	22	to	to	ADP
admet-929	264	23	a	a	DET
admet-929	264	24	single	single	ADJ
admet-929	264	25	protein	protein	NOUN
admet-929	264	26	.	.	PUNCT
admet-929	265	1	however	however	ADV
admet-929	265	2	,	,	PUNCT
admet-929	265	3	when	when	SCONJ
admet-929	265	4	using	use	VERB
admet-929	265	5	the	the	DET
admet-929	265	6	lowest	low	ADJ
admet-929	265	7	ipa	ipa	PROPN
admet-929	265	8	concentration	concentration	NOUN
admet-929	265	9	in	in	ADP
admet-929	265	10	the	the	DET
admet-929	265	11	mobile	mobile	ADJ
admet-929	265	12	phase	phase	NOUN
admet-929	265	13	(	(	PUNCT
admet-929	265	14	5	5	NUM
admet-929	265	15	%	%	NOUN
admet-929	265	16	)	)	PUNCT
admet-929	265	17	,	,	PUNCT
admet-929	265	18	the	the	DET
admet-929	265	19	data	datum	NOUN
admet-929	265	20	obtained	obtain	VERB
admet-929	265	21	was	be	AUX
admet-929	265	22	between	between	ADP
admet-929	265	23	77	77	NUM
admet-929	265	24	and	and	CCONJ
admet-929	265	25	87	87	NUM
admet-929	265	26	%	%	NOUN
admet-929	265	27	for	for	ADP
admet-929	265	28	the	the	DET
admet-929	265	29	enantiomers	enantiomer	NOUN
admet-929	265	30	of	of	ADP
admet-929	265	31	cq	cq	NOUN
admet-929	265	32	and	and	CCONJ
admet-929	265	33	hcq	hcq	NOUN
admet-929	265	34	.	.	PUNCT
admet-929	266	1	the	the	DET
admet-929	266	2	in	in	ADP
admet-929	266	3	vivo	vivo	NOUN
admet-929	266	4	pk	pk	NOUN
admet-929	266	5	data	datum	NOUN
admet-929	266	6	also	also	ADV
admet-929	266	7	showed	show	VERB
admet-929	266	8	large	large	ADJ
admet-929	266	9	individual	individual	ADJ
admet-929	266	10	variations	variation	NOUN
admet-929	266	11	in	in	ADP
admet-929	266	12	humans	human	NOUN
admet-929	266	13	which	which	PRON
admet-929	266	14	suggests	suggest	VERB
admet-929	266	15	that	that	SCONJ
admet-929	266	16	these	these	DET
admet-929	266	17	compounds	compound	NOUN
admet-929	266	18	may	may	AUX
admet-929	266	19	bind	bind	VERB
admet-929	266	20	to	to	ADP
admet-929	266	21	a	a	DET
admet-929	266	22	particular	particular	ADJ
admet-929	266	23	type	type	NOUN
admet-929	266	24	of	of	ADP
admet-929	266	25	negatively	negatively	ADV
admet-929	266	26	charged	charge	VERB
admet-929	266	27	proteins	protein	NOUN
admet-929	266	28	in	in	ADP
admet-929	266	29	plasma	plasma	NOUN
admet-929	266	30	and	and	CCONJ
admet-929	266	31	in	in	ADP
admet-929	266	32	tissues	tissue	NOUN
admet-929	266	33	that	that	PRON
admet-929	266	34	may	may	AUX
admet-929	266	35	have	have	VERB
admet-929	266	36	large	large	ADJ
admet-929	266	37	concentration	concentration	NOUN
admet-929	266	38	variations	variation	NOUN
admet-929	266	39	.	.	PUNCT
admet-929	267	1	table	table	NOUN
admet-929	267	2	9	9	NUM
admet-929	267	3	.	.	PUNCT
admet-929	268	1	the	the	DET
admet-929	268	2	estimated	estimate	VERB
admet-929	268	3	in	in	ADP
admet-929	268	4	vivo	vivo	ADJ
admet-929	268	5	properties	property	NOUN
admet-929	268	6	of	of	ADP
admet-929	268	7	cq	cq	NOUN
admet-929	268	8	and	and	CCONJ
admet-929	268	9	hcq	hcq	NOUN
admet-929	268	10	enantiomers	enantiomer	NOUN
admet-929	268	11	obtained	obtain	VERB
admet-929	268	12	from	from	ADP
admet-929	268	13	the	the	DET
admet-929	268	14	data	datum	NOUN
admet-929	268	15	when	when	SCONJ
admet-929	268	16	the	the	DET
admet-929	268	17	protein	protein	NOUN
admet-929	268	18	binding	bind	VERB
admet-929	268	19	was	be	AUX
admet-929	268	20	obtained	obtain	VERB
admet-929	268	21	with	with	ADP
admet-929	268	22	the	the	DET
admet-929	268	23	15	15	NUM
admet-929	268	24	%	%	NOUN
admet-929	268	25	ipa	ipa	PROPN
admet-929	268	26	isocratic	isocratic	PROPN
admet-929	268	27	conditions	condition	NOUN
admet-929	268	28	.	.	PUNCT
admet-929	269	1	property	property	NOUN
admet-929	269	2	(	(	PUNCT
admet-929	269	3	+	+	NOUN
admet-929	269	4	)	)	PUNCT
admet-929	269	5	s	s	PART
admet-929	269	6	cq	cq	NOUN
admet-929	269	7	(	(	PUNCT
admet-929	269	8	-)r	-)r	PROPN
admet-929	269	9	cq	cq	PROPN
admet-929	269	10	(	(	PUNCT
admet-929	269	11	+	+	NOUN
admet-929	269	12	)	)	PUNCT
admet-929	269	13	s	s	AUX
admet-929	269	14	hcq	hcq	NOUN
admet-929	269	15	(	(	PUNCT
admet-929	269	16	-)-r	-)-r	INTJ
admet-929	269	17	hcq	hcq	NOUN
admet-929	269	18	%	%	NOUN
admet-929	269	19	bound	bind	VERB
admet-929	269	20	hsa	hsa	PROPN
admet-929	269	21	79.9	79.9	NUM
admet-929	269	22	79.9	79.9	NUM
admet-929	269	23	79.9	79.9	NUM
admet-929	269	24	79.9	79.9	NUM
admet-929	269	25	%	%	NOUN
admet-929	269	26	bound	bind	VERB
admet-929	269	27	agp	agp	PROPN
admet-929	269	28	82.0	82.0	NUM
admet-929	269	29	81.0	81.0	NUM
admet-929	269	30	85.1	85.1	NUM
admet-929	269	31	87.3	87.3	NUM
admet-929	269	32	calc%	calc%	PUNCT
admet-929	269	33	ppb	ppb	VERB
admet-929	269	34	89.9	89.9	NUM
admet-929	269	35	89.7	89.7	NUM
admet-929	269	36	89.0	89.0	NUM
admet-929	269	37	88.9	88.9	NUM
admet-929	269	38	chi	chi	ADJ
admet-929	269	39	logd2	logd2	NOUN
admet-929	269	40	-1.2	-1.2	NOUN
admet-929	269	41	-1.2	-1.2	PROPN
admet-929	269	42	-1.3	-1.3	PROPN
admet-929	269	43	-1.3	-1.3	PROPN
admet-929	269	44	chi	chi	PROPN
admet-929	269	45	logd7.4	logd7.4	PROPN
admet-929	269	46	0.8	0.8	NUM
admet-929	269	47	0.8	0.8	NUM
admet-929	269	48	0.7	0.7	NUM
admet-929	269	49	0.7	0.7	NUM
admet-929	269	50	chi	chi	NOUN
admet-929	269	51	logd10.5	logd10.5	ADJ
admet-929	269	52	2.7	2.7	NUM
admet-929	269	53	2.7	2.7	NUM
admet-929	269	54	2.1	2.1	NUM
admet-929	269	55	2.1	2.1	NUM
admet-929	269	56	chilogp	chilogp	NOUN
admet-929	269	57	2.68	2.68	NUM
admet-929	269	58	2.7	2.7	NUM
admet-929	269	59	2.1	2.1	NUM
admet-929	269	60	2.1	2.1	NUM
admet-929	269	61	chi	chi	PROPN
admet-929	269	62	iam	iam	PROPN
admet-929	269	63	46.92	46.92	NUM
admet-929	269	64	46.9	46.9	NUM
admet-929	269	65	45.4	45.4	NUM
admet-929	269	66	45.4	45.4	NUM
admet-929	269	67	cad	cad	NOUN
admet-929	269	68	-	-	PUNCT
admet-929	269	69	likeness	likeness	NOUN
admet-929	269	70	82.89	82.89	NUM
admet-929	269	71	82.9	82.9	NUM
admet-929	269	72	73.6	73.6	NUM
admet-929	269	73	73.6	73.6	NUM
admet-929	269	74	%	%	NOUN
admet-929	269	75	btb	btb	ADP
admet-929	269	76	97.26	97.26	NUM
admet-929	269	77	97.3	97.3	NUM
admet-929	269	78	96.7	96.7	NUM
admet-929	269	79	96.7	96.7	NUM
admet-929	269	80	est	est	X
admet-929	269	81	log	log	NOUN
admet-929	270	1	k	k	PROPN
admet-929	271	1	bb	bb	INTJ
admet-929	271	2	0.96	0.96	NUM
admet-929	271	3	1.0	1.0	NUM
admet-929	271	4	0.9	0.9	NUM
admet-929	271	5	0.9	0.9	NUM
admet-929	271	6	brain	brain	NOUN
admet-929	271	7	to	to	PART
admet-929	271	8	plasma	plasma	VERB
admet-929	271	9	4.06	4.06	NUM
admet-929	271	10	4.0	4.0	NUM
admet-929	271	11	3.1	3.1	NUM
admet-929	271	12	3.0	3.0	NUM
admet-929	271	13	log	log	NOUN
admet-929	271	14	vd	vd	NOUN
admet-929	271	15	0.94	0.94	NUM
admet-929	271	16	0.9	0.9	NUM
admet-929	271	17	0.8	0.8	NUM
admet-929	271	18	0.8	0.8	NUM
admet-929	271	19	vd	vd	NOUN
admet-929	271	20	l	l	X
admet-929	271	21	/	/	SYM
admet-929	271	22	kg	kg	PROPN
admet-929	271	23	8.65	8.65	NUM
admet-929	271	24	8.7	8.7	NUM
admet-929	271	25	6.7	6.7	NUM
admet-929	271	26	6.6	6.6	NUM
admet-929	271	27	log	log	NOUN
admet-929	271	28	vdu	vdu	PROPN
admet-929	271	29	1.63	1.63	NUM
admet-929	271	30	1.6	1.6	NUM
admet-929	271	31	1.5	1.5	NUM
admet-929	271	32	1.5	1.5	NUM
admet-929	271	33	vdu	vdu	PROPN
admet-929	271	34	43.01	43.01	NUM
admet-929	271	35	43.0	43.0	NUM
admet-929	271	36	33.5	33.5	NUM
admet-929	271	37	33.3	33.3	NUM
admet-929	271	38	demax%	demax%	NUM
admet-929	271	39	2.33	2.33	NUM
admet-929	271	40	2.3	2.3	NUM
admet-929	271	41	23.0	23.0	NUM
admet-929	271	42	3.0	3.0	NUM
admet-929	271	43	%	%	NOUN
admet-929	271	44	lung	lung	NOUN
admet-929	271	45	tissue	tissue	NOUN
admet-929	271	46	binding	bind	VERB
admet-929	271	47	96.05	96.05	NUM
admet-929	271	48	95.1	95.1	NUM
admet-929	271	49	92.6	92.6	NUM
admet-929	271	50	92.7	92.7	NUM
admet-929	272	1	it	it	PRON
admet-929	272	2	can	can	AUX
admet-929	272	3	be	be	AUX
admet-929	272	4	seen	see	VERB
admet-929	272	5	that	that	SCONJ
admet-929	272	6	the	the	DET
admet-929	272	7	estimated	estimate	VERB
admet-929	272	8	distribution	distribution	NOUN
admet-929	272	9	data	datum	NOUN
admet-929	272	10	shown	show	VERB
admet-929	272	11	in	in	ADP
admet-929	272	12	table	table	NOUN
admet-929	272	13	7	7	NUM
admet-929	272	14	and	and	CCONJ
admet-929	272	15	table	table	NOUN
admet-929	272	16	9	9	NUM
admet-929	272	17	are	be	AUX
admet-929	272	18	very	very	ADV
admet-929	272	19	similar	similar	ADJ
admet-929	272	20	,	,	PUNCT
admet-929	272	21	and	and	CCONJ
admet-929	272	22	do	do	AUX
admet-929	272	23	not	not	PART
admet-929	272	24	differ	differ	VERB
admet-929	272	25	significantly	significantly	ADV
admet-929	272	26	despite	despite	SCONJ
admet-929	272	27	the	the	DET
admet-929	272	28	large	large	ADJ
admet-929	272	29	differences	difference	NOUN
admet-929	272	30	in	in	ADP
admet-929	272	31	the	the	DET
admet-929	272	32	%	%	NOUN
admet-929	272	33	protein	protein	NOUN
admet-929	272	34	binding	bind	VERB
admet-929	272	35	data	datum	NOUN
admet-929	272	36	.	.	PUNCT
admet-929	273	1	it	it	PRON
admet-929	273	2	is	be	AUX
admet-929	273	3	important	important	ADJ
admet-929	273	4	to	to	PART
admet-929	273	5	note	note	VERB
admet-929	273	6	that	that	SCONJ
admet-929	273	7	the	the	DET
admet-929	273	8	%	%	NOUN
admet-929	273	9	binding	bind	VERB
admet-929	273	10	data	datum	NOUN
admet-929	273	11	are	be	AUX
admet-929	273	12	not	not	PART
admet-929	273	13	linearly	linearly	ADV
admet-929	273	14	related	relate	VERB
admet-929	273	15	to	to	ADP
admet-929	273	16	the	the	DET
admet-929	273	17	protein	protein	NOUN
admet-929	273	18	binding	bind	VERB
admet-929	273	19	partition	partition	NOUN
admet-929	273	20	coefficients	coefficient	NOUN
admet-929	273	21	.	.	PUNCT
admet-929	274	1	still	still	ADV
admet-929	274	2	,	,	PUNCT
admet-929	274	3	they	they	PRON
admet-929	274	4	have	have	VERB
admet-929	274	5	a	a	DET
admet-929	274	6	sigmoidal	sigmoidal	NOUN
admet-929	274	7	relationship	relationship	NOUN
admet-929	274	8	with	with	ADP
admet-929	274	9	the	the	DET
admet-929	274	10	log	log	NOUN
admet-929	274	11	k	k	PROPN
admet-929	274	12	and	and	CCONJ
admet-929	274	13	logarithmic	logarithmic	ADJ
admet-929	274	14	retention	retention	NOUN
admet-929	274	15	time	time	NOUN
admet-929	274	16	data	data	PROPN
admet-929	274	17	.	.	PUNCT
admet-929	275	1	this	this	PRON
admet-929	275	2	means	mean	VERB
admet-929	275	3	that	that	SCONJ
admet-929	275	4	small	small	ADJ
admet-929	275	5	variations	variation	NOUN
admet-929	275	6	in	in	ADP
admet-929	275	7	the	the	DET
admet-929	275	8	log	log	NOUN
admet-929	275	9	k	k	PROPN
admet-929	275	10	hsa	hsa	PROPN
admet-929	275	11	and	and	CCONJ
admet-929	275	12	log	log	VERB
admet-929	275	13	k	k	PROPN
admet-929	275	14	agp	agp	PROPN
admet-929	275	15	values	value	NOUN
admet-929	275	16	result	result	VERB
admet-929	275	17	in	in	ADP
admet-929	275	18	a	a	DET
admet-929	275	19	large	large	ADJ
admet-929	275	20	variation	variation	NOUN
admet-929	275	21	when	when	SCONJ
admet-929	275	22	expressed	express	VERB
admet-929	275	23	as	as	ADP
admet-929	275	24	percentage	percentage	NOUN
admet-929	275	25	binding	bind	VERB
admet-929	275	26	in	in	ADP
admet-929	275	27	the	the	DET
admet-929	275	28	range	range	NOUN
admet-929	275	29	of	of	ADP
admet-929	275	30	30	30	NUM
admet-929	275	31	to	to	PART
admet-929	275	32	80	80	NUM
admet-929	275	33	%	%	NOUN
admet-929	275	34	.	.	PUNCT
admet-929	276	1	in	in	ADP
admet-929	276	2	the	the	DET
admet-929	276	3	stronger	strong	ADJ
admet-929	276	4	binding	binding	ADJ
admet-929	276	5	range	range	NOUN
admet-929	276	6	,	,	PUNCT
admet-929	276	7	large	large	ADJ
admet-929	276	8	variations	variation	NOUN
admet-929	276	9	in	in	ADP
admet-929	276	10	retention	retention	NOUN
admet-929	276	11	times	time	NOUN
admet-929	276	12	will	will	AUX
admet-929	276	13	result	result	VERB
admet-929	276	14	in	in	ADP
admet-929	276	15	only	only	ADV
admet-929	276	16	a	a	DET
admet-929	276	17	small	small	ADJ
admet-929	276	18	per	per	ADP
admet-929	276	19	cent	cent	NOUN
admet-929	276	20	of	of	ADP
admet-929	276	21	change	change	NOUN
admet-929	276	22	.	.	PUNCT
admet-929	277	1	the	the	DET
admet-929	277	2	biomimetic	biomimetic	ADJ
admet-929	277	3	protein	protein	NOUN
admet-929	277	4	binding	bind	VERB
admet-929	277	5	data	datum	NOUN
admet-929	277	6	have	have	AUX
admet-929	277	7	been	be	AUX
admet-929	277	8	validated	validate	VERB
admet-929	277	9	for	for	ADP
admet-929	277	10	differentiating	differentiate	VERB
admet-929	277	11	between	between	ADP
admet-929	277	12	strong	strong	ADJ
admet-929	277	13	binders	binder	NOUN
admet-929	277	14	and	and	CCONJ
admet-929	277	15	are	be	AUX
admet-929	277	16	more	more	ADV
admet-929	277	17	accurate	accurate	ADJ
admet-929	277	18	in	in	ADP
admet-929	277	19	that	that	DET
admet-929	277	20	region	region	NOUN
admet-929	278	1	[	[	X
admet-929	278	2	30	30	NUM
admet-929	278	3	]	]	PUNCT
admet-929	278	4	.	.	PUNCT
admet-929	279	1	conflict	conflict	NOUN
admet-929	279	2	of	of	ADP
admet-929	279	3	interest	interest	NOUN
admet-929	279	4	:	:	PUNCT
admet-929	279	5	klara	klara	PROPN
admet-929	279	6	valko	valko	PROPN
admet-929	279	7	is	be	AUX
admet-929	279	8	the	the	DET
admet-929	279	9	founder	founder	NOUN
admet-929	279	10	of	of	ADP
admet-929	279	11	biomimetic	biomimetic	PROPN
admet-929	279	12	chromatography	chromatography	PROPN
admet-929	279	13	ltd	ltd	PROPN
admet-929	279	14	and	and	CCONJ
admet-929	279	15	tong	tong	PROPN
admet-929	279	16	chang	chang	PROPN
admet-929	279	17	is	be	AUX
admet-929	279	18	a	a	DET
admet-929	279	19	scientist	scientist	NOUN
admet-929	279	20	at	at	ADP
admet-929	279	21	chiral	chiral	ADJ
admet-929	279	22	technologies	technology	NOUN
admet-929	279	23	europe	europe	PROPN
admet-929	279	24	.	.	PUNCT
admet-929	280	1	conclusions	conclusion	NOUN
admet-929	280	2	cq	cq	PROPN
admet-929	280	3	and	and	CCONJ
admet-929	280	4	hcq	hcq	PROPN
admet-929	280	5	have	have	AUX
admet-929	280	6	gained	gain	VERB
admet-929	280	7	renewed	renew	VERB
admet-929	280	8	interest	interest	NOUN
admet-929	280	9	as	as	ADP
admet-929	280	10	potential	potential	ADJ
admet-929	280	11	cures	cure	NOUN
admet-929	280	12	for	for	ADP
admet-929	280	13	covid-19	covid-19	PROPN
admet-929	280	14	when	when	SCONJ
admet-929	280	15	used	use	VERB
admet-929	280	16	in	in	ADP
admet-929	280	17	combination	combination	NOUN
admet-929	280	18	with	with	ADP
admet-929	280	19	antibiotics	antibiotic	NOUN
admet-929	280	20	and	and	CCONJ
admet-929	280	21	zinc	zinc	NOUN
admet-929	280	22	.	.	PUNCT
admet-929	281	1	biomimetic	biomimetic	ADJ
admet-929	281	2	properties	property	NOUN
admet-929	281	3	derived	derive	VERB
admet-929	281	4	from	from	ADP
admet-929	281	5	biomimetic	biomimetic	ADJ
admet-929	281	6	hplc	hplc	NOUN
admet-929	281	7	stationary	stationary	ADJ
admet-929	281	8	phases	phase	NOUN
admet-929	281	9	have	have	VERB
admet-929	281	10	https://doi.org/10.5599/admet.929	https://doi.org/10.5599/admet.929	NOUN
admet-929	281	11	klara	klara	PROPN
admet-929	281	12	valko	valko	PROPN
admet-929	281	13	and	and	CCONJ
admet-929	281	14	tong	tong	PROPN
admet-929	281	15	zhang	zhang	PROPN
admet-929	281	16	admet	admet	PROPN
admet-929	281	17	&	&	CCONJ
admet-929	281	18	dmpk	dmpk	PROPN
admet-929	281	19	9(2	9(2	NUM
admet-929	281	20	)	)	PUNCT
admet-929	281	21	(	(	PUNCT
admet-929	281	22	2021	2021	NUM
admet-929	281	23	)	)	PUNCT
admet-929	281	24	151	151	NUM
admet-929	281	25	-	-	SYM
admet-929	281	26	165	165	NUM
admet-929	281	27	162	162	NUM
admet-929	281	28	never	never	ADV
admet-929	281	29	been	be	AUX
admet-929	281	30	measured	measure	VERB
admet-929	281	31	for	for	ADP
admet-929	281	32	these	these	DET
admet-929	281	33	compounds	compound	NOUN
admet-929	281	34	.	.	PUNCT
admet-929	282	1	cq	cq	NOUN
admet-929	282	2	and	and	CCONJ
admet-929	282	3	hcq	hcq	PROPN
admet-929	282	4	did	do	AUX
admet-929	282	5	not	not	PART
admet-929	282	6	show	show	VERB
admet-929	282	7	extreme	extreme	ADJ
admet-929	282	8	phospholipid	phospholipid	NOUN
admet-929	282	9	-	-	PUNCT
admet-929	282	10	binding	binding	NOUN
admet-929	282	11	that	that	PRON
admet-929	282	12	would	would	AUX
admet-929	282	13	give	give	VERB
admet-929	282	14	the	the	DET
admet-929	282	15	compounds	compound	NOUN
admet-929	282	16	a	a	DET
admet-929	282	17	negative	negative	ADJ
admet-929	282	18	toxicity	toxicity	NOUN
admet-929	282	19	profile	profile	NOUN
admet-929	282	20	.	.	PUNCT
admet-929	283	1	cq	cq	NOUN
admet-929	283	2	and	and	CCONJ
admet-929	283	3	hcq	hcq	NOUN
admet-929	283	4	bind	bind	VERB
admet-929	283	5	to	to	ADP
admet-929	283	6	agp	agp	NOUN
admet-929	283	7	very	very	ADV
admet-929	283	8	strongly	strongly	ADV
admet-929	283	9	and	and	CCONJ
admet-929	283	10	stereoselectively	stereoselectively	ADV
admet-929	283	11	,	,	PUNCT
admet-929	283	12	though	though	SCONJ
admet-929	283	13	there	there	PRON
admet-929	283	14	is	be	VERB
admet-929	283	15	no	no	DET
admet-929	283	16	significant	significant	ADJ
admet-929	283	17	difference	difference	NOUN
admet-929	283	18	between	between	ADP
admet-929	283	19	cq	cq	NOUN
admet-929	283	20	and	and	CCONJ
admet-929	283	21	hcq	hcq	NOUN
admet-929	283	22	in	in	ADP
admet-929	283	23	this	this	DET
admet-929	283	24	regard	regard	NOUN
admet-929	283	25	.	.	PUNCT
admet-929	284	1	the	the	DET
admet-929	284	2	stereoselective	stereoselective	NOUN
admet-929	284	3	binding	bind	VERB
admet-929	284	4	to	to	ADP
admet-929	284	5	agp	agp	PROPN
admet-929	284	6	did	do	AUX
admet-929	284	7	not	not	PART
admet-929	284	8	result	result	VERB
admet-929	284	9	in	in	ADP
admet-929	284	10	significant	significant	ADJ
admet-929	284	11	differences	difference	NOUN
admet-929	284	12	in	in	ADP
admet-929	284	13	the	the	DET
admet-929	284	14	estimated	estimate	VERB
admet-929	284	15	total	total	ADJ
admet-929	284	16	plasma	plasma	NOUN
admet-929	284	17	protein	protein	NOUN
admet-929	284	18	binding	bind	VERB
admet-929	284	19	,	,	PUNCT
admet-929	284	20	lung	lung	NOUN
admet-929	284	21	tissue	tissue	NOUN
admet-929	284	22	binding	bind	VERB
admet-929	284	23	and	and	CCONJ
admet-929	284	24	volume	volume	NOUN
admet-929	284	25	of	of	ADP
admet-929	284	26	distribution	distribution	NOUN
admet-929	284	27	.	.	PUNCT
admet-929	285	1	the	the	DET
admet-929	285	2	retention	retention	NOUN
admet-929	285	3	time	time	NOUN
admet-929	285	4	measurements	measurement	NOUN
admet-929	285	5	are	be	AUX
admet-929	285	6	very	very	ADV
admet-929	285	7	reproducible	reproducible	ADJ
admet-929	285	8	on	on	ADP
admet-929	285	9	the	the	DET
admet-929	285	10	biomimetic	biomimetic	ADJ
admet-929	285	11	columns	column	NOUN
admet-929	285	12	,	,	PUNCT
admet-929	285	13	but	but	CCONJ
admet-929	285	14	the	the	DET
admet-929	285	15	absolute	absolute	ADJ
admet-929	285	16	values	value	NOUN
admet-929	285	17	of	of	ADP
admet-929	285	18	the	the	DET
admet-929	285	19	calculated	calculated	ADJ
admet-929	285	20	binding	bind	VERB
admet-929	285	21	data	datum	NOUN
admet-929	285	22	originate	originate	VERB
admet-929	285	23	from	from	ADP
admet-929	285	24	the	the	DET
admet-929	285	25	error	error	NOUN
admet-929	285	26	of	of	ADP
admet-929	285	27	the	the	DET
admet-929	285	28	calibration	calibration	NOUN
admet-929	285	29	line	line	NOUN
admet-929	285	30	fit	fit	ADJ
admet-929	285	31	.	.	PUNCT
admet-929	286	1	however	however	ADV
admet-929	286	2	,	,	PUNCT
admet-929	286	3	the	the	DET
admet-929	286	4	order	order	NOUN
admet-929	286	5	of	of	ADP
admet-929	286	6	the	the	DET
admet-929	286	7	retention	retention	NOUN
admet-929	286	8	data	datum	NOUN
admet-929	286	9	is	be	AUX
admet-929	286	10	very	very	ADV
admet-929	286	11	reproducible	reproducible	ADJ
admet-929	286	12	.	.	PUNCT
admet-929	287	1	the	the	DET
admet-929	287	2	in	in	ADP
admet-929	287	3	vivo	vivo	ADJ
admet-929	287	4	distribution	distribution	NOUN
admet-929	287	5	models	model	NOUN
admet-929	287	6	include	include	VERB
admet-929	287	7	0.5	0.5	NUM
admet-929	287	8	to	to	PART
admet-929	287	9	1	1	NUM
admet-929	287	10	log	log	NOUN
admet-929	287	11	unit	unit	NOUN
admet-929	287	12	errors	error	NOUN
admet-929	287	13	but	but	CCONJ
admet-929	287	14	again	again	ADV
admet-929	287	15	the	the	DET
admet-929	287	16	rank	rank	NOUN
admet-929	287	17	order	order	NOUN
admet-929	287	18	of	of	ADP
admet-929	287	19	the	the	DET
admet-929	287	20	compounds	compound	NOUN
admet-929	287	21	is	be	AUX
admet-929	287	22	reproducible	reproducible	ADJ
admet-929	287	23	.	.	PUNCT
admet-929	288	1	the	the	DET
admet-929	288	2	comparison	comparison	NOUN
admet-929	288	3	between	between	ADP
admet-929	288	4	the	the	DET
admet-929	288	5	estimated	estimate	VERB
admet-929	288	6	distribution	distribution	NOUN
admet-929	288	7	properties	property	NOUN
admet-929	288	8	and	and	CCONJ
admet-929	288	9	the	the	DET
admet-929	288	10	properties	property	NOUN
admet-929	288	11	published	publish	VERB
admet-929	288	12	in	in	ADP
admet-929	288	13	the	the	DET
admet-929	288	14	literature	literature	NOUN
admet-929	288	15	show	show	VERB
admet-929	288	16	great	great	ADJ
admet-929	288	17	variations	variation	NOUN
admet-929	288	18	,	,	PUNCT
admet-929	288	19	however	however	ADV
admet-929	288	20	the	the	DET
admet-929	288	21	biomimetic	biomimetic	ADJ
admet-929	288	22	protein	protein	NOUN
admet-929	288	23	binding	bind	VERB
admet-929	288	24	data	datum	NOUN
admet-929	288	25	were	be	AUX
admet-929	288	26	greater	great	ADJ
admet-929	288	27	than	than	ADP
admet-929	288	28	the	the	DET
admet-929	288	29	measured	measured	ADJ
admet-929	288	30	plasma	plasma	NOUN
admet-929	288	31	protein	protein	NOUN
admet-929	288	32	binding	bind	VERB
admet-929	288	33	data	datum	NOUN
admet-929	288	34	obtained	obtain	VERB
admet-929	288	35	by	by	ADP
admet-929	288	36	equilibrium	equilibrium	NOUN
admet-929	288	37	dialysis	dialysis	NOUN
admet-929	288	38	.	.	PUNCT
admet-929	289	1	the	the	DET
admet-929	289	2	aim	aim	NOUN
admet-929	289	3	of	of	ADP
admet-929	289	4	the	the	DET
admet-929	289	5	study	study	NOUN
admet-929	289	6	was	be	AUX
admet-929	289	7	to	to	PART
admet-929	289	8	differentiate	differentiate	VERB
admet-929	289	9	the	the	DET
admet-929	289	10	binding	binding	NOUN
admet-929	289	11	of	of	ADP
admet-929	289	12	the	the	DET
admet-929	289	13	various	various	ADJ
admet-929	289	14	enantiomers	enantiomer	NOUN
admet-929	289	15	and	and	CCONJ
admet-929	289	16	estimate	estimate	VERB
admet-929	289	17	the	the	DET
admet-929	289	18	in	in	ADP
admet-929	289	19	vivo	vivo	ADJ
admet-929	289	20	distribution	distribution	NOUN
admet-929	289	21	of	of	ADP
admet-929	289	22	each	each	DET
admet-929	289	23	enantiomer	enantiomer	NOUN
admet-929	289	24	.	.	PUNCT
admet-929	290	1	it	it	PRON
admet-929	290	2	was	be	AUX
admet-929	290	3	found	find	VERB
admet-929	290	4	that	that	SCONJ
admet-929	290	5	the	the	DET
admet-929	290	6	small	small	ADJ
admet-929	290	7	differences	difference	NOUN
admet-929	290	8	in	in	ADP
admet-929	290	9	the	the	DET
admet-929	290	10	protein	protein	NOUN
admet-929	290	11	binding	bind	VERB
admet-929	290	12	data	datum	NOUN
admet-929	290	13	did	do	AUX
admet-929	290	14	not	not	PART
admet-929	290	15	manifest	manifest	VERB
admet-929	290	16	itself	itself	PRON
admet-929	290	17	in	in	ADP
admet-929	290	18	significant	significant	ADJ
admet-929	290	19	differences	difference	NOUN
admet-929	290	20	in	in	ADP
admet-929	290	21	the	the	DET
admet-929	290	22	predicted	predict	VERB
admet-929	290	23	in	in	ADP
admet-929	290	24	vivo	vivo	ADJ
admet-929	290	25	distribution	distribution	NOUN
admet-929	290	26	data	datum	NOUN
admet-929	290	27	,	,	PUNCT
admet-929	290	28	so	so	SCONJ
admet-929	290	29	this	this	PRON
admet-929	290	30	can	can	AUX
admet-929	290	31	not	not	PART
admet-929	290	32	explain	explain	VERB
admet-929	290	33	the	the	DET
admet-929	290	34	observed	observed	ADJ
admet-929	290	35	differences	difference	NOUN
admet-929	290	36	in	in	ADP
admet-929	290	37	the	the	DET
admet-929	290	38	in	in	ADP
admet-929	290	39	vivo	vivo	ADJ
admet-929	290	40	activity	activity	NOUN
admet-929	290	41	of	of	ADP
admet-929	290	42	the	the	DET
admet-929	290	43	enantiomers	enantiomer	NOUN
admet-929	290	44	.	.	PUNCT
admet-929	291	1	it	it	PRON
admet-929	291	2	was	be	AUX
admet-929	291	3	found	find	VERB
admet-929	291	4	that	that	SCONJ
admet-929	291	5	the	the	DET
admet-929	291	6	drugs	drug	NOUN
admet-929	291	7	bind	bind	VERB
admet-929	291	8	to	to	ADP
admet-929	291	9	glycoproteins	glycoprotein	NOUN
admet-929	291	10	that	that	PRON
admet-929	291	11	are	be	AUX
admet-929	291	12	present	present	ADJ
admet-929	291	13	in	in	ADP
admet-929	291	14	humans	human	NOUN
admet-929	291	15	in	in	ADP
admet-929	291	16	variable	variable	ADJ
admet-929	291	17	amounts	amount	NOUN
admet-929	291	18	from	from	ADP
admet-929	291	19	various	various	ADJ
admet-929	291	20	disease	disease	NOUN
admet-929	291	21	states	state	NOUN
admet-929	291	22	,	,	PUNCT
admet-929	291	23	which	which	PRON
admet-929	291	24	may	may	AUX
admet-929	291	25	explain	explain	VERB
admet-929	291	26	the	the	DET
admet-929	291	27	big	big	ADJ
admet-929	291	28	variations	variation	NOUN
admet-929	291	29	observed	observe	VERB
admet-929	291	30	in	in	ADP
admet-929	291	31	the	the	DET
admet-929	291	32	in	in	ADP
admet-929	291	33	vivo	vivo	ADJ
admet-929	291	34	distribution	distribution	NOUN
admet-929	291	35	and	and	CCONJ
admet-929	291	36	protein	protein	NOUN
admet-929	291	37	binding	bind	VERB
admet-929	291	38	data	datum	NOUN
admet-929	291	39	.	.	PUNCT
admet-929	292	1	references	reference	NOUN
admet-929	292	2	[	[	X
admet-929	292	3	1	1	NUM
admet-929	292	4	]	]	PUNCT
admet-929	292	5	k.	k.	PROPN
admet-929	292	6	krafts	krafts	PROPN
admet-929	292	7	,	,	PUNCT
admet-929	292	8	e.	e.	PROPN
admet-929	292	9	hempelmann	hempelmann	PROPN
admet-929	292	10	,	,	PUNCT
admet-929	292	11	a.	a.	PROPN
admet-929	292	12	skórska	skórska	NOUN
admet-929	292	13	-	-	PUNCT
admet-929	292	14	stania	stania	NOUN
admet-929	292	15	.	.	PUNCT
admet-929	293	1	from	from	ADP
admet-929	293	2	methylene	methylene	ADJ
admet-929	293	3	blue	blue	NOUN
admet-929	293	4	to	to	ADP
admet-929	293	5	chloroquine	chloroquine	NOUN
admet-929	293	6	:	:	PUNCT
admet-929	293	7	a	a	DET
admet-929	293	8	brief	brief	ADJ
admet-929	293	9	review	review	NOUN
admet-929	293	10	of	of	ADP
admet-929	293	11	the	the	DET
admet-929	293	12	development	development	NOUN
admet-929	293	13	of	of	ADP
admet-929	293	14	an	an	DET
admet-929	293	15	antimalarial	antimalarial	ADJ
admet-929	293	16	therapy	therapy	NOUN
admet-929	293	17	.	.	PUNCT
admet-929	294	1	parasitol	parasitol	NOUN
admet-929	294	2	.	.	PUNCT
admet-929	295	1	res	re	NOUN
admet-929	295	2	.	.	NOUN
admet-929	295	3	111	111	NUM
admet-929	295	4	(	(	PUNCT
admet-929	295	5	2012	2012	NUM
admet-929	295	6	)	)	PUNCT
admet-929	296	1	1–6	1–6	NUM
admet-929	296	2	.	.	PUNCT
admet-929	297	1	doi	doi	NOUN
admet-929	297	2	:	:	PUNCT
admet-929	297	3	https://doi.org/10.1007/s00436-012-2886-x	https://doi.org/10.1007/s00436-012-2886-x	NOUN
admet-929	297	4	.	.	PUNCT
admet-929	298	1	[	[	X
admet-929	298	2	2	2	X
admet-929	298	3	]	]	X
admet-929	298	4	y.	y.	PROPN
admet-929	298	5	shimizu	shimizu	PROPN
admet-929	298	6	,	,	PUNCT
admet-929	298	7	s.	s.	PROPN
admet-929	298	8	yamamoto	yamamoto	PROPN
admet-929	298	9	,	,	PUNCT
admet-929	298	10	m.	m.	PROPN
admet-929	298	11	homma	homma	PROPN
admet-929	298	12	,	,	PUNCT
admet-929	298	13	n.	n.	PROPN
admet-929	298	14	ishida	ishida	PROPN
admet-929	298	15	.	.	PUNCT
admet-929	299	1	effect	effect	NOUN
admet-929	299	2	of	of	ADP
admet-929	299	3	chloroquine	chloroquine	NOUN
admet-929	299	4	on	on	ADP
admet-929	299	5	the	the	DET
admet-929	299	6	growth	growth	NOUN
admet-929	299	7	of	of	ADP
admet-929	299	8	animal	animal	NOUN
admet-929	299	9	viruses	virus	NOUN
admet-929	299	10	.	.	PUNCT
admet-929	300	1	arch	arch	NOUN
admet-929	300	2	.	.	PUNCT
admet-929	301	1	gesamte	gesamte	NOUN
admet-929	301	2	virusforsch	virusforsch	PROPN
admet-929	301	3	.	.	PUNCT
admet-929	302	1	36	36	NUM
admet-929	302	2	(	(	PUNCT
admet-929	302	3	1972	1972	NUM
admet-929	302	4	)	)	PUNCT
admet-929	302	5	93–104	93–104	PROPN
admet-929	302	6	.	.	PUNCT
admet-929	302	7	doi	doi	PROPN
admet-929	302	8	:	:	PUNCT
admet-929	302	9	https://doi.org/10.1007/bf01250299	https://doi.org/10.1007/bf01250299	X
admet-929	302	10	.	.	PUNCT
admet-929	303	1	[	[	X
admet-929	303	2	3	3	X
admet-929	303	3	]	]	X
admet-929	303	4	j.m	j.m	PROPN
admet-929	303	5	.	.	PROPN
admet-929	303	6	rolain	rolain	PROPN
admet-929	303	7	,	,	PUNCT
admet-929	303	8	p.	p.	PROPN
admet-929	303	9	colson	colson	PROPN
admet-929	303	10	,	,	PUNCT
admet-929	303	11	d.	d.	PROPN
admet-929	303	12	raoult	raoult	PROPN
admet-929	303	13	.	.	PUNCT
admet-929	304	1	recycling	recycling	NOUN
admet-929	304	2	of	of	ADP
admet-929	304	3	chloroquine	chloroquine	NOUN
admet-929	304	4	and	and	CCONJ
admet-929	304	5	its	its	PRON
admet-929	304	6	hydroxyl	hydroxyl	NOUN
admet-929	304	7	analogue	analogue	NOUN
admet-929	304	8	to	to	PART
admet-929	304	9	face	face	VERB
admet-929	304	10	bacterial	bacterial	ADJ
admet-929	304	11	,	,	PUNCT
admet-929	304	12	fungal	fungal	ADJ
admet-929	304	13	and	and	CCONJ
admet-929	304	14	viral	viral	ADJ
admet-929	304	15	infections	infection	NOUN
admet-929	304	16	in	in	ADP
admet-929	304	17	the	the	DET
admet-929	304	18	21st	21st	ADJ
admet-929	304	19	century	century	NOUN
admet-929	304	20	.	.	PUNCT
admet-929	305	1	int	int	NOUN
admet-929	305	2	.	.	PUNCT
admet-929	306	1	j.	j.	PROPN
admet-929	306	2	antimicrob	antimicrob	PROPN
admet-929	306	3	.	.	PUNCT
admet-929	307	1	agents	agent	NOUN
admet-929	307	2	30	30	NUM
admet-929	307	3	(	(	PUNCT
admet-929	307	4	2007	2007	NUM
admet-929	307	5	)	)	PUNCT
admet-929	307	6	297–308	297–308	NUM
admet-929	307	7	.	.	PUNCT
admet-929	308	1	doi	doi	NOUN
admet-929	308	2	:	:	PUNCT
admet-929	308	3	https://doi.org/10.1016/j.ijantimicag.2007.05.015	https://doi.org/10.1016/j.ijantimicag.2007.05.015	ADV
admet-929	308	4	.	.	PUNCT
admet-929	309	1	[	[	X
admet-929	309	2	4	4	X
admet-929	309	3	]	]	PUNCT
admet-929	309	4	h.	h.	PROPN
admet-929	309	5	lu	lu	PROPN
admet-929	309	6	,	,	PUNCT
admet-929	309	7	c.w	c.w	PROPN
admet-929	309	8	.	.	PROPN
admet-929	309	9	stratton	stratton	PROPN
admet-929	309	10	,	,	PUNCT
admet-929	309	11	y.w	y.w	PROPN
admet-929	309	12	.	.	PROPN
admet-929	309	13	tang	tang	PROPN
admet-929	309	14	.	.	PUNCT
admet-929	310	1	outbreak	outbreak	NOUN
admet-929	310	2	of	of	ADP
admet-929	310	3	pneumonia	pneumonia	NOUN
admet-929	310	4	of	of	ADP
admet-929	310	5	unknown	unknown	ADJ
admet-929	310	6	etiology	etiology	NOUN
admet-929	310	7	in	in	ADP
admet-929	310	8	wuhan	wuhan	PROPN
admet-929	310	9	,	,	PUNCT
admet-929	310	10	china	china	PROPN
admet-929	310	11	:	:	PUNCT
admet-929	310	12	the	the	DET
admet-929	310	13	mystery	mystery	NOUN
admet-929	310	14	and	and	CCONJ
admet-929	310	15	the	the	DET
admet-929	310	16	miracle	miracle	NOUN
admet-929	310	17	.	.	PUNCT
admet-929	311	1	j.	j.	PROPN
admet-929	311	2	med	med	PROPN
admet-929	311	3	.	.	PUNCT
admet-929	311	4	virol	virol	PROPN
admet-929	311	5	.	.	PUNCT
admet-929	312	1	92	92	NUM
admet-929	312	2	(	(	PUNCT
admet-929	312	3	2020	2020	NUM
admet-929	312	4	)	)	PUNCT
admet-929	313	1	401–402	401–402	NUM
admet-929	313	2	.	.	PUNCT
admet-929	313	3	doi	doi	PROPN
admet-929	313	4	:	:	PUNCT
admet-929	313	5	https://doi.org/10.1002/jmv.25678	https://doi.org/10.1002/jmv.25678	PROPN
admet-929	313	6	.	.	PUNCT
admet-929	314	1	[	[	X
admet-929	314	2	5	5	NUM
admet-929	314	3	]	]	PUNCT
admet-929	314	4	r.	r.	PROPN
admet-929	314	5	lu	lu	PROPN
admet-929	314	6	,	,	PUNCT
admet-929	314	7	x.	x.	PROPN
admet-929	314	8	zhao	zhao	PROPN
admet-929	314	9	,	,	PUNCT
admet-929	314	10	j.	j.	PROPN
admet-929	314	11	li	li	PROPN
admet-929	314	12	,	,	PUNCT
admet-929	314	13	p.	p.	PROPN
admet-929	314	14	niu	niu	PROPN
admet-929	314	15	,	,	PUNCT
admet-929	314	16	b.	b.	PROPN
admet-929	314	17	yang	yang	PROPN
admet-929	314	18	,	,	PUNCT
admet-929	314	19	h.	h.	PROPN
admet-929	314	20	wu	wu	PROPN
admet-929	314	21	,	,	PUNCT
admet-929	314	22	w.	w.	PROPN
admet-929	314	23	wang	wang	PROPN
admet-929	314	24	,	,	PUNCT
admet-929	314	25	h.	h.	PROPN
admet-929	314	26	song	song	PROPN
admet-929	314	27	,	,	PUNCT
admet-929	314	28	b.	b.	PROPN
admet-929	314	29	huang	huang	PROPN
admet-929	314	30	,	,	PUNCT
admet-929	314	31	n.	n.	PROPN
admet-929	314	32	zhu	zhu	PROPN
admet-929	314	33	,	,	PUNCT
admet-929	314	34	y.	y.	PROPN
admet-929	314	35	bi	bi	PROPN
admet-929	314	36	,	,	PUNCT
admet-929	314	37	x.	x.	PROPN
admet-929	314	38	ma	ma	PROPN
admet-929	314	39	,	,	PUNCT
admet-929	314	40	f.	f.	PROPN
admet-929	314	41	zhan	zhan	PROPN
admet-929	314	42	,	,	PUNCT
admet-929	314	43	l.	l.	PROPN
admet-929	314	44	wang	wang	PROPN
admet-929	314	45	,	,	PUNCT
admet-929	314	46	t.	t.	PROPN
admet-929	314	47	hu	hu	PROPN
admet-929	314	48	,	,	PUNCT
admet-929	314	49	h.	h.	PROPN
admet-929	314	50	zhou	zhou	PROPN
admet-929	314	51	,	,	PUNCT
admet-929	314	52	z.	z.	PROPN
admet-929	314	53	hu	hu	PROPN
admet-929	314	54	,	,	PUNCT
admet-929	314	55	w.	w.	PROPN
admet-929	314	56	zhou	zhou	PROPN
admet-929	314	57	,	,	PUNCT
admet-929	314	58	l.	l.	PROPN
admet-929	314	59	zhao	zhao	PROPN
admet-929	314	60	,	,	PUNCT
admet-929	314	61	j.	j.	PROPN
admet-929	314	62	chen	chen	PROPN
admet-929	314	63	,	,	PUNCT
admet-929	314	64	y.	y.	PROPN
admet-929	314	65	meng	meng	PROPN
admet-929	314	66	,	,	PUNCT
admet-929	314	67	j.	j.	PROPN
admet-929	314	68	wang	wang	PROPN
admet-929	314	69	,	,	PUNCT
admet-929	314	70	y.	y.	PROPN
admet-929	314	71	lin	lin	PROPN
admet-929	314	72	,	,	PUNCT
admet-929	314	73	j.	j.	PROPN
admet-929	314	74	yuan	yuan	PROPN
admet-929	314	75	,	,	PUNCT
admet-929	314	76	z.	z.	PROPN
admet-929	314	77	xie	xie	PROPN
admet-929	314	78	,	,	PUNCT
admet-929	314	79	j.	j.	PROPN
admet-929	314	80	ma	ma	PROPN
admet-929	314	81	,	,	PUNCT
admet-929	314	82	w.j	w.j	PROPN
admet-929	314	83	.	.	PROPN
admet-929	314	84	liu	liu	PROPN
admet-929	314	85	,	,	PUNCT
admet-929	314	86	d.	d.	PROPN
admet-929	314	87	wang	wang	PROPN
admet-929	314	88	,	,	PUNCT
admet-929	314	89	w.	w.	PROPN
admet-929	314	90	xu	xu	PROPN
admet-929	314	91	,	,	PUNCT
admet-929	314	92	e.c	e.c	PROPN
admet-929	314	93	.	.	PROPN
admet-929	314	94	holmes	holmes	PROPN
admet-929	314	95	,	,	PUNCT
admet-929	314	96	g.f	g.f	PROPN
admet-929	314	97	.	.	PROPN
admet-929	314	98	gao	gao	PROPN
admet-929	314	99	,	,	PUNCT
admet-929	314	100	g.	g.	PROPN
admet-929	314	101	wu	wu	PROPN
admet-929	314	102	,	,	PUNCT
admet-929	314	103	w.	w.	PROPN
admet-929	314	104	chen	chen	PROPN
admet-929	314	105	,	,	PUNCT
admet-929	314	106	w.	w.	PROPN
admet-929	314	107	shi	shi	PROPN
admet-929	314	108	,	,	PUNCT
admet-929	314	109	w.	w.	PROPN
admet-929	314	110	tan	tan	PROPN
admet-929	314	111	.	.	PUNCT
admet-929	315	1	genomic	genomic	ADJ
admet-929	315	2	characterisation	characterisation	NOUN
admet-929	315	3	and	and	CCONJ
admet-929	315	4	epidemiology	epidemiology	NOUN
admet-929	315	5	of	of	ADP
admet-929	315	6	2019	2019	NUM
admet-929	315	7	novel	novel	ADJ
admet-929	315	8	coronavirus	coronavirus	NOUN
admet-929	315	9	:	:	PUNCT
admet-929	315	10	implications	implication	NOUN
admet-929	315	11	for	for	ADP
admet-929	315	12	virus	virus	NOUN
admet-929	315	13	origins	origin	NOUN
admet-929	315	14	and	and	CCONJ
admet-929	315	15	receptor	receptor	NOUN
admet-929	315	16	binding	bind	VERB
admet-929	315	17	.	.	PUNCT
admet-929	316	1	lancet	lancet	VERB
admet-929	316	2	395	395	NUM
admet-929	316	3	(	(	PUNCT
admet-929	316	4	2020	2020	NUM
admet-929	316	5	)	)	PUNCT
admet-929	316	6	565–574	565–574	NUM
admet-929	316	7	.	.	PUNCT
admet-929	317	1	doi	doi	NOUN
admet-929	317	2	:	:	PUNCT
admet-929	317	3	https://doi.org/10.1016/s0140-6736(20)30251-8	https://doi.org/10.1016/s0140-6736(20)30251-8	NOUN
admet-929	317	4	.	.	PUNCT
admet-929	318	1	[	[	X
admet-929	318	2	6	6	NUM
admet-929	318	3	]	]	X
admet-929	318	4	t.j	t.j	PROPN
admet-929	318	5	.	.	PROPN
admet-929	318	6	oscanoa	oscanoa	PROPN
admet-929	318	7	,	,	PUNCT
admet-929	318	8	r.	r.	PROPN
admet-929	318	9	romero	romero	PROPN
admet-929	318	10	-	-	PUNCT
admet-929	318	11	ortuno	ortuno	PROPN
admet-929	318	12	,	,	PUNCT
admet-929	318	13	a.	a.	NOUN
admet-929	318	14	carvajal	carvajal	PROPN
admet-929	318	15	,	,	PUNCT
admet-929	318	16	a.	a.	NOUN
admet-929	318	17	savarino	savarino	PROPN
admet-929	318	18	.	.	PUNCT
admet-929	319	1	a	a	DET
admet-929	319	2	pharmacological	pharmacological	ADJ
admet-929	319	3	perspective	perspective	NOUN
admet-929	319	4	of	of	ADP
admet-929	319	5	chloroquine	chloroquine	NOUN
admet-929	319	6	in	in	ADP
admet-929	319	7	sars	sar	NOUN
admet-929	319	8	-	-	PUNCT
admet-929	319	9	cov-2	cov-2	PART
admet-929	319	10	infection	infection	NOUN
admet-929	319	11	.	.	PUNCT
admet-929	320	1	int	int	NOUN
admet-929	320	2	.	.	PUNCT
admet-929	321	1	j.	j.	PROPN
admet-929	321	2	antimicrob	antimicrob	PROPN
admet-929	321	3	.	.	PUNCT
admet-929	322	1	agents	agent	NOUN
admet-929	322	2	56	56	NUM
admet-929	322	3	(	(	PUNCT
admet-929	322	4	2020	2020	NUM
admet-929	322	5	)	)	PUNCT
admet-929	322	6	106078	106078	NUM
admet-929	322	7	.	.	PUNCT
admet-929	323	1	doi	doi	NOUN
admet-929	323	2	:	:	PUNCT
admet-929	323	3	https://doi.org/10.1016/j.ijantimicag.2020.106078	https://doi.org/10.1016/j.ijantimicag.2020.106078	PROPN
admet-929	323	4	.	.	PUNCT
admet-929	324	1	[	[	X
admet-929	324	2	7	7	X
admet-929	324	3	]	]	X
admet-929	324	4	j.	j.	PROPN
admet-929	324	5	xue	xue	PROPN
admet-929	324	6	,	,	PUNCT
admet-929	324	7	a.	a.	PROPN
admet-929	324	8	moyer	moyer	PROPN
admet-929	324	9	,	,	PUNCT
admet-929	324	10	b.	b.	PROPN
admet-929	324	11	peng	peng	PROPN
admet-929	324	12	,	,	PUNCT
admet-929	324	13	j.	j.	PROPN
admet-929	324	14	wu	wu	PROPN
admet-929	324	15	,	,	PUNCT
admet-929	324	16	b.n	b.n	PROPN
admet-929	324	17	.	.	PROPN
admet-929	324	18	hannafon	hannafon	PROPN
admet-929	324	19	,	,	PUNCT
admet-929	324	20	w.q	w.q	PROPN
admet-929	324	21	.	.	PROPN
admet-929	324	22	ding	ding	PROPN
admet-929	324	23	.	.	PUNCT
admet-929	325	1	chloroquine	chloroquine	PROPN
admet-929	325	2	is	be	AUX
admet-929	325	3	a	a	DET
admet-929	325	4	zinc	zinc	NOUN
admet-929	325	5	ionophore	ionophore	NOUN
admet-929	325	6	.	.	PUNCT
admet-929	326	1	plos	plos	PROPN
admet-929	326	2	one	one	NUM
admet-929	326	3	9	9	NUM
admet-929	326	4	(	(	PUNCT
admet-929	326	5	2014	2014	NUM
admet-929	326	6	)	)	PUNCT
admet-929	327	1	1–6	1–6	NUM
admet-929	327	2	.	.	PUNCT
admet-929	328	1	doi	doi	NOUN
admet-929	328	2	:	:	PUNCT
admet-929	328	3	https://doi.org/10.1371/journal.pone.0109180	https://doi.org/10.1371/journal.pone.0109180	NOUN
admet-929	328	4	.	.	PUNCT
admet-929	329	1	[	[	X
admet-929	329	2	8	8	X
admet-929	329	3	]	]	PUNCT
admet-929	329	4	j.	j.	PROPN
admet-929	329	5	zheng	zheng	PROPN
admet-929	329	6	,	,	PUNCT
admet-929	329	7	x.x	x.x	PROPN
admet-929	329	8	.	.	PROPN
admet-929	329	9	zhang	zhang	PROPN
admet-929	329	10	,	,	PUNCT
admet-929	329	11	h.	h.	PROPN
admet-929	329	12	yu	yu	PROPN
admet-929	329	13	,	,	PUNCT
admet-929	329	14	j.e	j.e	PROPN
admet-929	329	15	.	.	PROPN
admet-929	329	16	taggart	taggart	PROPN
admet-929	329	17	,	,	PUNCT
admet-929	329	18	w.q	w.q	PROPN
admet-929	329	19	.	.	NOUN
admet-929	329	20	ding	ding	NOUN
admet-929	329	21	.	.	PUNCT
admet-929	330	1	zinc	zinc	NOUN
admet-929	330	2	at	at	ADP
admet-929	330	3	cytotoxic	cytotoxic	ADJ
admet-929	330	4	concentrations	concentration	NOUN
admet-929	330	5	affects	affect	VERB
admet-929	330	6	posttranscriptional	posttranscriptional	ADJ
admet-929	330	7	events	event	NOUN
admet-929	330	8	of	of	ADP
admet-929	330	9	gene	gene	NOUN
admet-929	330	10	expression	expression	NOUN
admet-929	330	11	in	in	ADP
admet-929	330	12	cancer	cancer	NOUN
admet-929	330	13	cells	cell	NOUN
admet-929	330	14	.	.	PUNCT
admet-929	331	1	cell	cell	NOUN
admet-929	331	2	.	.	PUNCT
admet-929	332	1	physiol	physiol	PROPN
admet-929	332	2	.	.	PUNCT
admet-929	333	1	biochem	biochem	PROPN
admet-929	333	2	.	.	PUNCT
admet-929	334	1	29	29	NUM
admet-929	334	2	(	(	PUNCT
admet-929	334	3	2012	2012	NUM
admet-929	334	4	)	)	PUNCT
admet-929	334	5	181	181	NUM
admet-929	334	6	–	–	PUNCT
admet-929	334	7	188	188	NUM
admet-929	334	8	.	.	PUNCT
admet-929	335	1	doi	doi	NOUN
admet-929	335	2	:	:	PUNCT
admet-929	335	3	https://doi.org/10.1159/000337599	https://doi.org/10.1159/000337599	X
admet-929	335	4	.	.	PUNCT
admet-929	336	1	[	[	X
admet-929	336	2	9	9	NUM
admet-929	336	3	]	]	X
admet-929	336	4	h.	h.	NOUN
admet-929	336	5	fieger	fieger	PROPN
admet-929	336	6	,	,	PUNCT
admet-929	336	7	j.	j.	PROPN
admet-929	336	8	iredale	iredale	PROPN
admet-929	336	9	,	,	PUNCT
admet-929	336	10	i.w	i.w	PROPN
admet-929	336	11	.	.	PROPN
admet-929	336	12	wainer	wainer	PROPN
admet-929	336	13	.	.	PUNCT
admet-929	337	1	enantioselective	enantioselective	ADJ
admet-929	337	2	determination	determination	NOUN
admet-929	337	3	of	of	ADP
admet-929	337	4	hydroxychloroquine	hydroxychloroquine	PROPN
admet-929	337	5	and	and	CCONJ
admet-929	337	6	its	its	PRON
admet-929	337	7	major	major	ADJ
admet-929	337	8	metabolites	metabolite	NOUN
admet-929	337	9	in	in	ADP
admet-929	337	10	urine	urine	NOUN
admet-929	337	11	and	and	CCONJ
admet-929	337	12	the	the	DET
admet-929	337	13	observation	observation	NOUN
admet-929	337	14	of	of	ADP
admet-929	337	15	a	a	DET
admet-929	337	16	reversal	reversal	NOUN
admet-929	337	17	in	in	ADP
admet-929	337	18	the	the	DET
admet-929	337	19	(	(	PUNCT
admet-929	337	20	+	+	NOUN
admet-929	337	21	)	)	PUNCT
admet-929	337	22	/(−)‐hydroxychloroquine	/(−)‐hydroxychloroquine	NOUN
admet-929	337	23	ratio	ratio	NOUN
admet-929	337	24	.	.	PUNCT
admet-929	338	1	chirality	chirality	NOUN
admet-929	338	2	5	5	NUM
admet-929	338	3	(	(	PUNCT
admet-929	338	4	1993	1993	NUM
admet-929	338	5	)	)	PUNCT
admet-929	338	6	65–70	65–70	NUM
admet-929	338	7	.	.	PUNCT
admet-929	339	1	doi	doi	NOUN
admet-929	339	2	:	:	PUNCT
admet-929	339	3	https://doi.org/10.1002/chir.530050205	https://doi.org/10.1002/chir.530050205	X
admet-929	339	4	.	.	PUNCT
admet-929	340	1	[	[	X
admet-929	340	2	10	10	NUM
admet-929	340	3	]	]	X
admet-929	340	4	y.	y.	PROPN
admet-929	340	5	wei	wei	PROPN
admet-929	340	6	,	,	PUNCT
admet-929	340	7	g.a	g.a	PROPN
admet-929	340	8	.	.	PROPN
admet-929	340	9	nygard	nygard	PROPN
admet-929	340	10	,	,	PUNCT
admet-929	340	11	s.l	s.l	PROPN
admet-929	340	12	.	.	PROPN
admet-929	340	13	ellertson	ellertson	PROPN
admet-929	340	14	,	,	PUNCT
admet-929	340	15	s.k.w	s.k.w	NOUN
admet-929	340	16	.	.	PUNCT
admet-929	341	1	khalil	khalil	PROPN
admet-929	341	2	.	.	PUNCT
admet-929	342	1	stereoselective	stereoselective	ADJ
admet-929	342	2	disposition	disposition	NOUN
admet-929	342	3	of	of	ADP
admet-929	342	4	hydroxychloroquine	hydroxychloroquine	NOUN
admet-929	342	5	and	and	CCONJ
admet-929	342	6	its	its	PRON
admet-929	342	7	metabolites	metabolite	NOUN
admet-929	342	8	in	in	ADP
admet-929	342	9	rats	rat	NOUN
admet-929	342	10	.	.	PUNCT
admet-929	343	1	chirality	chirality	NOUN
admet-929	343	2	7	7	NUM
admet-929	343	3	(	(	PUNCT
admet-929	343	4	1995	1995	NUM
admet-929	343	5	)	)	PUNCT
admet-929	344	1	598–604	598–604	NUM
admet-929	344	2	.	.	PUNCT
admet-929	345	1	doi	doi	NOUN
admet-929	345	2	:	:	PUNCT
admet-929	345	3	https://doi.org/10.1002/chir.530070807	https://doi.org/10.1002/chir.530070807	ADJ
admet-929	345	4	.	.	PUNCT
admet-929	346	1	https://doi.org/10.1007/s00436-012-2886-x	https://doi.org/10.1007/s00436-012-2886-x	PROPN
admet-929	346	2	https://doi.org/10.1007/s00436-012-2886-x	https://doi.org/10.1007/s00436-012-2886-x	NOUN
admet-929	346	3	https://doi.org/10.1007/bf01250299	https://doi.org/10.1007/bf01250299	PROPN
admet-929	346	4	https://doi.org/10.1016/j.ijantimicag.2007.05.015	https://doi.org/10.1016/j.ijantimicag.2007.05.015	PROPN
admet-929	346	5	https://doi.org/10.1002/jmv.25678	https://doi.org/10.1002/jmv.25678	PROPN
admet-929	346	6	https://doi.org/10.1016/s0140-6736(20)30251-8	https://doi.org/10.1016/s0140-6736(20)30251-8	PROPN
admet-929	346	7	https://doi.org/10.1016/j.ijantimicag.2020.106078	https://doi.org/10.1016/j.ijantimicag.2020.106078	PROPN
admet-929	346	8	https://doi.org/10.1371/journal.pone.0109180	https://doi.org/10.1371/journal.pone.0109180	PROPN
admet-929	346	9	https://doi.org/10.1159/000337599	https://doi.org/10.1159/000337599	PROPN
admet-929	346	10	https://doi.org/10.1002/chir.530050205	https://doi.org/10.1002/chir.530050205	X
admet-929	346	11	https://doi.org/10.1002/chir.530070807	https://doi.org/10.1002/chir.530070807	PROPN
admet-929	346	12	admet	admet	PROPN
admet-929	346	13	&	&	CCONJ
admet-929	346	14	dmpk	dmpk	PROPN
admet-929	346	15	9(2	9(2	NUM
admet-929	346	16	)	)	PUNCT
admet-929	346	17	(	(	PUNCT
admet-929	346	18	2021	2021	NUM
admet-929	346	19	)	)	PUNCT
admet-929	346	20	151	151	NUM
admet-929	346	21	-	-	SYM
admet-929	346	22	165	165	NUM
admet-929	346	23	biomimetic	biomimetic	ADJ
admet-929	346	24	properties	property	NOUN
admet-929	346	25	of	of	ADP
admet-929	346	26	chlorquine	chlorquine	NOUN
admet-929	346	27	enantiomers	enantiomer	NOUN
admet-929	346	28	doi	doi	NOUN
admet-929	346	29	:	:	PUNCT
admet-929	346	30	https://doi.org/10.5599/admet.929	https://doi.org/10.5599/admet.929	NOUN
admet-929	346	31	163	163	NUM
admet-929	346	32	[	[	X
admet-929	346	33	11	11	NUM
admet-929	346	34	]	]	SYM
admet-929	346	35	c.m	c.m	PROPN
admet-929	346	36	.	.	PROPN
admet-929	346	37	eldefield	eldefield	PROPN
admet-929	346	38	e.o	e.o	PROPN
admet-929	346	39	.	.	PROPN
admet-929	346	40	titus	titus	PROPN
admet-929	346	41	,	,	PUNCT
admet-929	346	42	l.c	l.c	PROPN
admet-929	346	43	.	.	PROPN
admet-929	346	44	craig	craig	PROPN
admet-929	346	45	,	,	PUNCT
admet-929	346	46	c.	c.	PROPN
admet-929	346	47	golumbic	golumbic	PROPN
admet-929	346	48	,	,	PUNCT
admet-929	346	49	h.	h.	PROPN
admet-929	346	50	r.	r.	PROPN
admet-929	346	51	highton	highton	PROPN
admet-929	346	52	.	.	PUNCT
admet-929	347	1	identification	identification	NOUN
admet-929	347	2	by	by	ADP
admet-929	347	3	distribution	distribution	NOUN
admet-929	347	4	studies	study	NOUN
admet-929	347	5	;	;	PUNCT
admet-929	347	6	application	application	NOUN
admet-929	347	7	to	to	ADP
admet-929	347	8	metabolic	metabolic	NOUN
admet-929	347	9	studies	study	NOUN
admet-929	347	10	of	of	ADP
admet-929	347	11	4	4	NUM
admet-929	347	12	-	-	PUNCT
admet-929	347	13	aminoquinoline	aminoquinoline	NOUN
admet-929	347	14	antimalarial	antimalarial	NOUN
admet-929	347	15	.	.	PUNCT
admet-929	348	1	j.	j.	PROPN
admet-929	348	2	org	org	PROPN
admet-929	348	3	.	.	PUNCT
admet-929	349	1	chem	chem	PROPN
admet-929	349	2	.	.	PUNCT
admet-929	350	1	13	13	NUM
admet-929	350	2	(	(	PUNCT
admet-929	350	3	1948	1948	NUM
admet-929	350	4	)	)	PUNCT
admet-929	350	5	39–62	39–62	NUM
admet-929	350	6	.	.	PUNCT
admet-929	351	1	[	[	X
admet-929	351	2	12	12	NUM
admet-929	351	3	]	]	X
admet-929	351	4	h.s.d	h.s.d	NOUN
admet-929	351	5	.	.	PUNCT
admet-929	352	1	ofori	ofori	ADJ
admet-929	352	2	-	-	PUNCT
admet-929	352	3	adjei	adjei	PROPN
admet-929	352	4	,	,	PUNCT
admet-929	352	5	o.	o.	PROPN
admet-929	352	6	ericson	ericson	PROPN
admet-929	352	7	,	,	PUNCT
admet-929	352	8	b.	b.	PROPN
admet-929	352	9	lindström	lindström	PROPN
admet-929	352	10	,	,	PUNCT
admet-929	352	11	j.	j.	PROPN
admet-929	352	12	hermansson	hermansson	PROPN
admet-929	352	13	,	,	PUNCT
admet-929	352	14	k.	k.	PROPN
admet-929	352	15	adjepon	adjepon	PROPN
admet-929	352	16	-	-	PUNCT
admet-929	352	17	yamoah	yamoah	NOUN
admet-929	352	18	.	.	PUNCT
admet-929	353	1	enantioslective	enantioslective	ADJ
admet-929	353	2	analysis	analysis	NOUN
admet-929	353	3	of	of	ADP
admet-929	353	4	chloroquine	chloroquine	NOUN
admet-929	353	5	and	and	CCONJ
admet-929	353	6	desethylchloroquine	desethylchloroquine	NOUN
admet-929	353	7	after	after	ADP
admet-929	353	8	oral	oral	ADJ
admet-929	353	9	administration	administration	NOUN
admet-929	353	10	of	of	ADP
admet-929	353	11	racemic	racemic	ADJ
admet-929	353	12	chloroquine	chloroquine	NOUN
admet-929	353	13	.	.	PUNCT
admet-929	354	1	ther	ther	PROPN
admet-929	354	2	.	.	PUNCT
admet-929	355	1	drug	drug	PROPN
admet-929	355	2	monit	monit	PROPN
admet-929	355	3	.	.	PUNCT
admet-929	356	1	8	8	NUM
admet-929	356	2	(	(	PUNCT
admet-929	356	3	1986	1986	NUM
admet-929	356	4	)	)	PUNCT
admet-929	357	1	457–461	457–461	NUM
admet-929	357	2	.	.	PUNCT
admet-929	357	3	https://doi.org/10.1097/00007691-198612000-00014	https://doi.org/10.1097/00007691-198612000-00014	NOUN
admet-929	357	4	.	.	PUNCT
admet-929	358	1	[	[	X
admet-929	358	2	13	13	NUM
admet-929	358	3	]	]	PUNCT
admet-929	358	4	j.	j.	PROPN
admet-929	358	5	ducharme	ducharme	PROPN
admet-929	358	6	,	,	PUNCT
admet-929	358	7	h.	h.	PROPN
admet-929	358	8	fieger	fieger	PROPN
admet-929	358	9	,	,	PUNCT
admet-929	358	10	m.	m.	NOUN
admet-929	358	11	ducharme	ducharme	PROPN
admet-929	358	12	,	,	PUNCT
admet-929	358	13	s.	s.	PROPN
admet-929	358	14	khalil	khalil	PROPN
admet-929	358	15	,	,	PUNCT
admet-929	358	16	i.	i.	PROPN
admet-929	358	17	wainer	wainer	PROPN
admet-929	358	18	.	.	PUNCT
admet-929	359	1	enantioselective	enantioselective	ADJ
admet-929	359	2	disposition	disposition	NOUN
admet-929	359	3	of	of	ADP
admet-929	359	4	hydroxychloroquine	hydroxychloroquine	NOUN
admet-929	359	5	after	after	ADP
admet-929	359	6	a	a	DET
admet-929	359	7	single	single	ADJ
admet-929	359	8	oral	oral	ADJ
admet-929	359	9	dose	dose	NOUN
admet-929	359	10	of	of	ADP
admet-929	359	11	the	the	DET
admet-929	359	12	racemate	racemate	NOUN
admet-929	359	13	to	to	ADP
admet-929	359	14	healthy	healthy	ADJ
admet-929	359	15	subjects	subject	NOUN
admet-929	359	16	.	.	PUNCT
admet-929	360	1	br	br	X
admet-929	360	2	.	.	PUNCT
admet-929	361	1	j.	j.	PROPN
admet-929	361	2	clin	clin	PROPN
admet-929	361	3	.	.	PUNCT
admet-929	362	1	pharmacol	pharmacol	PROPN
admet-929	362	2	.	.	PROPN
admet-929	363	1	40	40	NUM
admet-929	363	2	(	(	PUNCT
admet-929	363	3	1995	1995	NUM
admet-929	363	4	)	)	PUNCT
admet-929	364	1	127–133	127–133	NUM
admet-929	364	2	.	.	PUNCT
admet-929	365	1	doi	doi	NOUN
admet-929	365	2	:	:	PUNCT
admet-929	366	1	https://doi.org/10.1111/j.1365-2125.1995.tb05768.x	https://doi.org/10.1111/j.1365-2125.1995.tb05768.x	PROPN
admet-929	366	2	.	.	PUNCT
admet-929	367	1	[	[	X
admet-929	367	2	14	14	NUM
admet-929	367	3	]	]	X
admet-929	367	4	s.	s.	PROPN
admet-929	367	5	fu	fu	PROPN
admet-929	367	6	,	,	PUNCT
admet-929	367	7	a.	a.	NOUN
admet-929	367	8	björkman	björkman	NOUN
admet-929	367	9	,	,	PUNCT
admet-929	367	10	d.	d.	PROPN
admet-929	367	11	ofori	ofori	PROPN
admet-929	367	12	-	-	PUNCT
admet-929	367	13	adjei	adjei	PROPN
admet-929	367	14	,	,	PUNCT
admet-929	367	15	b.	b.	PROPN
admet-929	367	16	wählin	wählin	PROPN
admet-929	367	17	,	,	PUNCT
admet-929	367	18	o.	o.	PROPN
admet-929	367	19	ericsson	ericsson	PROPN
admet-929	367	20	,	,	PUNCT
admet-929	367	21	f.	f.	PROPN
admet-929	367	22	sjöqvist	sjöqvist	PROPN
admet-929	367	23	.	.	PUNCT
admet-929	368	1	in	in	ADP
admet-929	368	2	vitro	vitro	X
admet-929	368	3	activity	activity	NOUN
admet-929	368	4	of	of	ADP
admet-929	368	5	chloroquine	chloroquine	NOUN
admet-929	368	6	,	,	PUNCT
admet-929	368	7	two	two	NUM
admet-929	368	8	enantiomers	enantiomer	NOUN
admet-929	368	9	of	of	ADP
admet-929	368	10	chloroquine	chloroquine	NOUN
admet-929	368	11	,	,	PUNCT
admet-929	368	12	desethylchloroquine	desethylchloroquine	NOUN
admet-929	368	13	and	and	CCONJ
admet-929	368	14	pyronaridine	pyronaridine	VERB
admet-929	368	15	against	against	ADP
admet-929	368	16	plasmodium	plasmodium	NOUN
admet-929	368	17	falciparum	falciparum	NOUN
admet-929	368	18	,	,	PUNCT
admet-929	368	19	br	br	PROPN
admet-929	368	20	.	.	PUNCT
admet-929	369	1	j.	j.	PROPN
admet-929	369	2	clin	clin	PROPN
admet-929	369	3	.	.	PUNCT
admet-929	370	1	pharmac	pharmac	PROPN
admet-929	370	2	.	.	PUNCT
admet-929	371	1	22	22	NUM
admet-929	371	2	(	(	PUNCT
admet-929	371	3	1986	1986	NUM
admet-929	371	4	)	)	PUNCT
admet-929	371	5	93	93	NUM
admet-929	371	6	-	-	SYM
admet-929	371	7	96	96	NUM
admet-929	371	8	.	.	PUNCT
admet-929	372	1	[	[	X
admet-929	372	2	15	15	NUM
admet-929	372	3	]	]	X
admet-929	372	4	g.b.a	g.b.a	NOUN
admet-929	372	5	.	.	PUNCT
admet-929	373	1	haberkorn	haberkorn	PROPN
admet-929	373	2	,	,	PUNCT
admet-929	373	3	h.p	h.p	PROPN
admet-929	373	4	.	.	PROPN
admet-929	373	5	kraft	kraft	PROPN
admet-929	373	6	,	,	PUNCT
admet-929	373	7	g.	g.	PROPN
admet-929	373	8	blaschke	blaschke	PROPN
admet-929	373	9	.	.	PUNCT
admet-929	374	1	antimalarial	antimalarial	ADJ
admet-929	374	2	activity	activity	NOUN
admet-929	374	3	in	in	ADP
admet-929	374	4	animals	animal	NOUN
admet-929	374	5	of	of	ADP
admet-929	374	6	the	the	DET
admet-929	374	7	optical	optical	ADJ
admet-929	374	8	isomers	isomer	NOUN
admet-929	374	9	of	of	ADP
admet-929	374	10	chloroquine	chloroquine	NOUN
admet-929	374	11	diphosphate	diphosphate	PROPN
admet-929	374	12	.	.	PUNCT
admet-929	375	1	tropenmed	tropenme	VERB
admet-929	375	2	parasitol	parasitol	NOUN
admet-929	375	3	.	.	PUNCT
admet-929	376	1	30	30	NUM
admet-929	376	2	(	(	PUNCT
admet-929	376	3	1979	1979	NUM
admet-929	376	4	)	)	PUNCT
admet-929	377	1	308–312	308–312	NUM
admet-929	377	2	.	.	PUNCT
admet-929	378	1	[	[	X
admet-929	378	2	16	16	NUM
admet-929	378	3	]	]	X
admet-929	378	4	r.f.j	r.f.j	NOUN
admet-929	378	5	.	.	PUNCT
admet-929	378	6	ducharme	ducharme	PROPN
admet-929	378	7	.	.	PUNCT
admet-929	379	1	clinical	clinical	ADJ
admet-929	379	2	pharmacokinetics	pharmacokinetic	NOUN
admet-929	379	3	and	and	CCONJ
admet-929	379	4	metabolism	metabolism	NOUN
admet-929	379	5	of	of	ADP
admet-929	379	6	chloroquine	chloroquine	NOUN
admet-929	379	7	.	.	PUNCT
admet-929	380	1	clin	clin	PROPN
admet-929	380	2	.	.	PUNCT
admet-929	380	3	pharmacokinet	pharmacokinet	PROPN
admet-929	380	4	.	.	PUNCT
admet-929	381	1	31	31	NUM
admet-929	381	2	(	(	PUNCT
admet-929	381	3	2012	2012	NUM
admet-929	381	4	)	)	PUNCT
admet-929	381	5	2570274	2570274	NUM
admet-929	381	6	.	.	PUNCT
admet-929	382	1	[	[	X
admet-929	382	2	17	17	NUM
admet-929	382	3	]	]	PUNCT
admet-929	382	4	i.	i.	PROPN
admet-929	382	5	d’acquarica	d’acquarica	PROPN
admet-929	382	6	,	,	PUNCT
admet-929	382	7	i.	i.	PROPN
admet-929	382	8	agranat	agranat	PROPN
admet-929	382	9	.	.	PUNCT
admet-929	383	1	chiral	chiral	ADJ
admet-929	383	2	switches	switch	NOUN
admet-929	383	3	of	of	ADP
admet-929	383	4	chloroquine	chloroquine	NOUN
admet-929	383	5	and	and	CCONJ
admet-929	383	6	hydroxychloroquine	hydroxychloroquine	PROPN
admet-929	383	7	:	:	PUNCT
admet-929	383	8	potential	potential	ADJ
admet-929	383	9	drugs	drug	NOUN
admet-929	383	10	to	to	PART
admet-929	383	11	treat	treat	VERB
admet-929	383	12	covid-19	covid-19	PROPN
admet-929	383	13	.	.	PUNCT
admet-929	383	14	drug	drug	NOUN
admet-929	383	15	discov	discov	NOUN
admet-929	383	16	.	.	PUNCT
admet-929	384	1	today	today	NOUN
admet-929	384	2	25	25	NUM
admet-929	384	3	(	(	PUNCT
admet-929	384	4	2020	2020	NUM
admet-929	384	5	)	)	PUNCT
admet-929	384	6	1121–1123	1121–1123	NUM
admet-929	384	7	.	.	PUNCT
admet-929	385	1	doi	doi	NOUN
admet-929	385	2	:	:	PUNCT
admet-929	385	3	https://doi.org/10.1016/j.drudis.2020.04.021	https://doi.org/10.1016/j.drudis.2020.04.021	NOUN
admet-929	385	4	.	.	PUNCT
admet-929	386	1	[	[	X
admet-929	386	2	18	18	NUM
admet-929	386	3	]	]	X
admet-929	386	4	j.	j.	PROPN
admet-929	386	5	iredale	iredale	PROPN
admet-929	386	6	,	,	PUNCT
admet-929	386	7	i.w	i.w	PROPN
admet-929	386	8	.	.	PROPN
admet-929	386	9	wainer	wainer	PROPN
admet-929	386	10	.	.	PUNCT
admet-929	387	1	determination	determination	NOUN
admet-929	387	2	of	of	ADP
admet-929	387	3	hydroxychloroquine	hydroxychloroquine	PROPN
admet-929	387	4	and	and	CCONJ
admet-929	387	5	its	its	PRON
admet-929	387	6	major	major	ADJ
admet-929	387	7	metabolites	metabolite	NOUN
admet-929	387	8	in	in	ADP
admet-929	387	9	plasma	plasma	NOUN
admet-929	387	10	using	use	VERB
admet-929	387	11	sequential	sequential	ADJ
admet-929	387	12	achiral	achiral	ADJ
admet-929	387	13	-	-	PUNCT
admet-929	387	14	chiral	chiral	ADJ
admet-929	387	15	high	high	ADJ
admet-929	387	16	-	-	PUNCT
admet-929	387	17	performance	performance	NOUN
admet-929	387	18	liquid	liquid	ADJ
admet-929	387	19	chromatography	chromatography	NOUN
admet-929	387	20	.	.	PUNCT
admet-929	388	1	j.	j.	PROPN
admet-929	388	2	chromatogr	chromatogr	PROPN
admet-929	388	3	.	.	PUNCT
admet-929	389	1	b	b	X
admet-929	389	2	biomed	biome	VERB
admet-929	389	3	.	.	PUNCT
admet-929	390	1	sci	sci	PROPN
admet-929	390	2	.	.	PROPN
admet-929	390	3	appl	appl	PROPN
admet-929	390	4	.	.	PUNCT
admet-929	391	1	573	573	NUM
admet-929	391	2	(	(	PUNCT
admet-929	391	3	1992	1992	NUM
admet-929	391	4	)	)	PUNCT
admet-929	392	1	253–258	253–258	NUM
admet-929	392	2	.	.	PUNCT
admet-929	393	1	doi	doi	NOUN
admet-929	393	2	:	:	PUNCT
admet-929	394	1	https://doi.org/10.1016/0378-4347(92)80126-b	https://doi.org/10.1016/0378-4347(92)80126-b	ADJ
admet-929	394	2	.	.	PUNCT
admet-929	395	1	[	[	X
admet-929	395	2	19	19	NUM
admet-929	395	3	]	]	X
admet-929	395	4	o.	o.	PROPN
admet-929	395	5	walker	walker	PROPN
admet-929	395	6	,	,	PUNCT
admet-929	395	7	d.	d.	PROPN
admet-929	395	8	birkett	birkett	PROPN
admet-929	395	9	,	,	PUNCT
admet-929	395	10	g.	g.	PROPN
admet-929	395	11	alvan	alvan	PROPN
admet-929	395	12	,	,	PUNCT
admet-929	395	13	l.	l.	PROPN
admet-929	395	14	gustafsson	gustafsson	PROPN
admet-929	395	15	,	,	PUNCT
admet-929	395	16	f.	f.	PROPN
admet-929	395	17	sjoqvist	sjoqvist	PROPN
admet-929	395	18	.	.	PUNCT
admet-929	396	1	characterization	characterization	NOUN
admet-929	396	2	of	of	ADP
admet-929	396	3	chloroquine	chloroquine	NOUN
admet-929	396	4	plasma	plasma	NOUN
admet-929	396	5	protein	protein	NOUN
admet-929	396	6	binding	bind	VERB
admet-929	396	7	in	in	ADP
admet-929	396	8	man	man	NOUN
admet-929	396	9	.	.	PUNCT
admet-929	397	1	br	br	PROPN
admet-929	397	2	.	.	PUNCT
admet-929	398	1	j.	j.	PROPN
admet-929	398	2	clin	clin	PROPN
admet-929	398	3	.	.	PUNCT
admet-929	399	1	pharmacol	pharmacol	PROPN
admet-929	399	2	.	.	PROPN
admet-929	400	1	15	15	NUM
admet-929	400	2	(	(	PUNCT
admet-929	400	3	1983	1983	NUM
admet-929	400	4	)	)	PUNCT
admet-929	401	1	375–377	375–377	NUM
admet-929	401	2	.	.	PUNCT
admet-929	402	1	doi	doi	NOUN
admet-929	402	2	:	:	PUNCT
admet-929	402	3	https://doi.org/10.1111/j.1365-2125.1983.tb01513.x	https://doi.org/10.1111/j.1365-2125.1983.tb01513.x	PROPN
admet-929	402	4	.	.	PUNCT
admet-929	403	1	[	[	X
admet-929	403	2	20	20	NUM
admet-929	403	3	]	]	X
admet-929	403	4	d.	d.	PROPN
admet-929	403	5	ofori‐adjei	ofori‐adjei	PROPN
admet-929	403	6	,	,	PUNCT
admet-929	403	7	o.	o.	PROPN
admet-929	403	8	ericsson	ericsson	PROPN
admet-929	403	9	,	,	PUNCT
admet-929	403	10	b.	b.	PROPN
admet-929	403	11	lindstrom	lindstrom	PROPN
admet-929	403	12	,	,	PUNCT
admet-929	403	13	f.	f.	PROPN
admet-929	403	14	sjoqvist	sjoqvist	PROPN
admet-929	403	15	.	.	PUNCT
admet-929	404	1	protein	protein	NOUN
admet-929	404	2	binding	bind	VERB
admet-929	404	3	of	of	ADP
admet-929	404	4	chloroquine	chloroquine	NOUN
admet-929	404	5	enantiomers	enantiomer	NOUN
admet-929	404	6	and	and	CCONJ
admet-929	404	7	desethylchloroquine	desethylchloroquine	NOUN
admet-929	404	8	.	.	PUNCT
admet-929	405	1	br	br	PROPN
admet-929	405	2	.	.	PUNCT
admet-929	406	1	j.	j.	PROPN
admet-929	406	2	clin	clin	PROPN
admet-929	406	3	.	.	PUNCT
admet-929	407	1	pharmacol	pharmacol	PROPN
admet-929	407	2	.	.	PUNCT
admet-929	408	1	22	22	NUM
admet-929	408	2	(	(	PUNCT
admet-929	408	3	1986	1986	NUM
admet-929	408	4	)	)	PUNCT
admet-929	409	1	356–358	356–358	PROPN
admet-929	409	2	.	.	PUNCT
admet-929	410	1	doi	doi	NOUN
admet-929	410	2	:	:	PUNCT
admet-929	410	3	https://doi.org/10.1111/j.13652125.1986.tb02900.x	https://doi.org/10.1111/j.13652125.1986.tb02900.x	NOUN
admet-929	410	4	.	.	PUNCT
admet-929	411	1	[	[	X
admet-929	411	2	21	21	NUM
admet-929	411	3	]	]	PUNCT
admet-929	411	4	a.	a.	NOUN
admet-929	411	5	mclachlan	mclachlan	PROPN
admet-929	411	6	,	,	PUNCT
admet-929	411	7	s.	s.	PROPN
admet-929	411	8	tett	tett	PROPN
admet-929	411	9	,	,	PUNCT
admet-929	411	10	d.	d.	PROPN
admet-929	411	11	cutler	cutler	PROPN
admet-929	411	12	,	,	PUNCT
admet-929	411	13	r.	r.	PROPN
admet-929	411	14	day	day	PROPN
admet-929	411	15	.	.	PUNCT
admet-929	412	1	disposition	disposition	NOUN
admet-929	412	2	of	of	ADP
admet-929	412	3	the	the	DET
admet-929	412	4	enantiomers	enantiomer	NOUN
admet-929	412	5	of	of	ADP
admet-929	412	6	hydroxychloroquine	hydroxychloroquine	NOUN
admet-929	412	7	in	in	ADP
admet-929	412	8	patients	patient	NOUN
admet-929	412	9	with	with	ADP
admet-929	412	10	rheumatoid	rheumatoid	NOUN
admet-929	412	11	arthritis	arthritis	NOUN
admet-929	412	12	following	follow	VERB
admet-929	412	13	multiple	multiple	ADJ
admet-929	412	14	doses	dose	NOUN
admet-929	412	15	of	of	ADP
admet-929	412	16	the	the	DET
admet-929	412	17	racemate	racemate	NOUN
admet-929	412	18	.	.	PUNCT
admet-929	413	1	br	br	PROPN
admet-929	413	2	.	.	PUNCT
admet-929	414	1	j.	j.	PROPN
admet-929	414	2	clin	clin	PROPN
admet-929	414	3	.	.	PUNCT
admet-929	415	1	pharmacol	pharmacol	PROPN
admet-929	415	2	.	.	PUNCT
admet-929	416	1	36	36	NUM
admet-929	416	2	(	(	PUNCT
admet-929	416	3	1993	1993	NUM
admet-929	416	4	)	)	PUNCT
admet-929	417	1	78–81	78–81	VERB
admet-929	417	2	.	.	PUNCT
admet-929	418	1	doi	doi	PROPN
admet-929	418	2	:	:	PUNCT
admet-929	418	3	https://doi.org/10.1111/j.1365-2125.1993.tb05897.x	https://doi.org/10.1111/j.1365-2125.1993.tb05897.x	PROPN
admet-929	418	4	.	.	PUNCT
admet-929	419	1	[	[	X
admet-929	419	2	22	22	NUM
admet-929	419	3	]	]	X
admet-929	419	4	k.e	k.e	PROPN
admet-929	419	5	.	.	PROPN
admet-929	419	6	ibrahim	ibrahim	PROPN
admet-929	419	7	,	,	PUNCT
admet-929	419	8	a.f	a.f	PROPN
admet-929	419	9	.	.	PROPN
admet-929	419	10	fell	fall	VERB
admet-929	419	11	.	.	PUNCT
admet-929	420	1	separation	separation	NOUN
admet-929	420	2	of	of	ADP
admet-929	420	3	chloroquine	chloroquine	NOUN
admet-929	420	4	enantiomers	enantiomer	NOUN
admet-929	420	5	by	by	ADP
admet-929	420	6	high	high	ADJ
admet-929	420	7	-	-	PUNCT
admet-929	420	8	performance	performance	NOUN
admet-929	420	9	liquid	liquid	ADJ
admet-929	420	10	chromatography	chromatography	NOUN
admet-929	420	11	.	.	PUNCT
admet-929	421	1	j.	j.	PROPN
admet-929	421	2	pharm	pharm	PROPN
admet-929	421	3	.	.	PUNCT
admet-929	421	4	biomed	biome	VERB
admet-929	421	5	.	.	PUNCT
admet-929	422	1	anal	anal	ADJ
admet-929	422	2	.	.	PUNCT
admet-929	423	1	8	8	NUM
admet-929	423	2	(	(	PUNCT
admet-929	423	3	1990	1990	NUM
admet-929	423	4	)	)	PUNCT
admet-929	424	1	449–452	449–452	NUM
admet-929	424	2	.	.	PUNCT
admet-929	425	1	doi	doi	NOUN
admet-929	425	2	:	:	PUNCT
admet-929	425	3	https://doi.org/10.1016/07317085(90)80074-y	https://doi.org/10.1016/07317085(90)80074-y	PROPN
admet-929	425	4	.	.	PUNCT
admet-929	426	1	[	[	X
admet-929	426	2	23	23	NUM
admet-929	426	3	]	]	PUNCT
admet-929	426	4	a.	a.	NOUN
admet-929	426	5	aubry	aubry	PROPN
admet-929	426	6	,	,	PUNCT
admet-929	426	7	f.	f.	PROPN
admet-929	426	8	gimenez	gimenez	PROPN
admet-929	426	9	,	,	PUNCT
admet-929	426	10	r.	r.	PROPN
admet-929	426	11	farinotti	farinotti	PROPN
admet-929	426	12	,	,	PUNCT
admet-929	426	13	i.w	i.w	PROPN
admet-929	426	14	.	.	PROPN
admet-929	426	15	wainer	wainer	PROPN
admet-929	426	16	.	.	PUNCT
admet-929	427	1	enantioselective	enantioselective	ADJ
admet-929	427	2	chromatography	chromatography	NOUN
admet-929	427	3	of	of	ADP
admet-929	427	4	the	the	DET
admet-929	427	5	antimalarial	antimalarial	ADJ
admet-929	427	6	agents	agent	NOUN
admet-929	427	7	chloroquine	chloroquine	NOUN
admet-929	427	8	,	,	PUNCT
admet-929	427	9	mefloquine	mefloquine	NOUN
admet-929	427	10	,	,	PUNCT
admet-929	427	11	and	and	CCONJ
admet-929	427	12	enpiroline	enpiroline	NOUN
admet-929	427	13	on	on	ADP
admet-929	427	14	a	a	DET
admet-929	427	15	α1	α1	ADJ
admet-929	427	16	-	-	PUNCT
admet-929	427	17	acid	acid	ADJ
admet-929	427	18	glycoprotein	glycoprotein	NOUN
admet-929	427	19	chiral	chiral	ADJ
admet-929	427	20	stationary	stationary	ADJ
admet-929	427	21	phase	phase	NOUN
admet-929	427	22	.	.	PUNCT
admet-929	428	1	chirality	chirality	NOUN
admet-929	428	2	35	35	NUM
admet-929	428	3	(	(	PUNCT
admet-929	428	4	1992	1992	NUM
admet-929	428	5	)	)	PUNCT
admet-929	428	6	3–8	3–8	X
admet-929	428	7	.	.	PUNCT
admet-929	429	1	doi	doi	NOUN
admet-929	429	2	:	:	PUNCT
admet-929	429	3	https://doi.org/10.1002/chir.530040108	https://doi.org/10.1002/chir.530040108	X
admet-929	429	4	.	.	PUNCT
admet-929	430	1	[	[	X
admet-929	430	2	24	24	NUM
admet-929	430	3	]	]	X
admet-929	430	4	g.	g.	PROPN
admet-929	430	5	li	li	PROPN
admet-929	430	6	,	,	PUNCT
admet-929	430	7	j.	j.	PROPN
admet-929	430	8	sun	sun	PROPN
admet-929	430	9	,	,	PUNCT
admet-929	430	10	y.y	y.y	PROPN
admet-929	430	11	.	.	PROPN
admet-929	430	12	huang	huang	PROPN
admet-929	430	13	,	,	PUNCT
admet-929	430	14	y.	y.	PROPN
admet-929	430	15	li	li	PROPN
admet-929	430	16	,	,	PUNCT
admet-929	430	17	y.	y.	PROPN
admet-929	430	18	shi	shi	PROPN
admet-929	430	19	,	,	PUNCT
admet-929	430	20	z.	z.	PROPN
admet-929	430	21	li	li	PROPN
admet-929	430	22	,	,	PUNCT
admet-929	430	23	x.	x.	PROPN
admet-929	430	24	li	li	PROPN
admet-929	430	25	,	,	PUNCT
admet-929	430	26	f.h	f.h	PROPN
admet-929	430	27	.	.	PROPN
admet-929	430	28	yang	yang	PROPN
admet-929	430	29	,	,	PUNCT
admet-929	430	30	j.	j.	PROPN
admet-929	430	31	zhao	zhao	PROPN
admet-929	430	32	,	,	PUNCT
admet-929	430	33	h.b	h.b	PROPN
admet-929	430	34	.	.	PROPN
admet-929	430	35	luo	luo	PROPN
admet-929	430	36	,	,	PUNCT
admet-929	430	37	t.	t.	PROPN
admet-929	430	38	zhang	zhang	PROPN
admet-929	430	39	,	,	PUNCT
admet-929	430	40	x.	x.	PROPN
admet-929	430	41	zhang	zhang	PROPN
admet-929	430	42	.	.	PUNCT
admet-929	430	43	enantiomers	enantiomer	NOUN
admet-929	430	44	of	of	ADP
admet-929	430	45	chloroquine	chloroquine	NOUN
admet-929	430	46	and	and	CCONJ
admet-929	430	47	hydroxychloroquine	hydroxychloroquine	PROPN
admet-929	430	48	exhibit	exhibit	VERB
admet-929	430	49	different	different	ADJ
admet-929	430	50	activities	activity	NOUN
admet-929	430	51	against	against	ADP
admet-929	430	52	sars	sar	NOUN
admet-929	430	53	-	-	PUNCT
admet-929	430	54	cov-2	cov-2	NOUN
admet-929	430	55	in	in	ADP
admet-929	430	56	vitro	vitro	X
admet-929	430	57	,	,	PUNCT
admet-929	430	58	evidencing	evidencing	NOUN
admet-929	430	59	s	s	NOUN
admet-929	430	60	-hydroxychloroquine	-hydroxychloroquine	NOUN
admet-929	430	61	as	as	ADP
admet-929	430	62	a	a	DET
admet-929	430	63	potentially	potentially	ADV
admet-929	430	64	superior	superior	ADJ
admet-929	430	65	drug	drug	NOUN
admet-929	430	66	for	for	ADP
admet-929	430	67	covid-19	covid-19	PROPN
admet-929	430	68	.	.	PUNCT
admet-929	431	1	(	(	PUNCT
admet-929	431	2	2020	2020	NUM
admet-929	431	3	)	)	PUNCT
admet-929	431	4	.	.	PUNCT
admet-929	432	1	doi	doi	NOUN
admet-929	432	2	:	:	PUNCT
admet-929	432	3	https://doi.org/10.1101/2020.05.26.114033	https://doi.org/10.1101/2020.05.26.114033	NOUN
admet-929	432	4	.	.	PUNCT
admet-929	433	1	[	[	X
admet-929	433	2	25	25	NUM
admet-929	433	3	]	]	PUNCT
admet-929	433	4	daicel	daicel	X
admet-929	433	5	chiral	chiral	ADJ
admet-929	433	6	application	application	NOUN
admet-929	433	7	,	,	PUNCT
admet-929	433	8	n.d	n.d	PROPN
admet-929	433	9	.	.	PROPN
admet-929	433	10	https://search.daicelchiral.com	https://search.daicelchiral.com	PROPN
admet-929	433	11	.	.	PUNCT
admet-929	434	1	[	[	X
admet-929	434	2	26	26	NUM
admet-929	434	3	]	]	X
admet-929	434	4	k.l	k.l	PROPN
admet-929	434	5	.	.	PROPN
admet-929	434	6	valko	valko	PROPN
admet-929	434	7	,	,	PUNCT
admet-929	434	8	s.p	s.p	PROPN
admet-929	434	9	.	.	PROPN
admet-929	434	10	teague	teague	PROPN
admet-929	434	11	,	,	PUNCT
admet-929	434	12	c.	c.	PROPN
admet-929	434	13	pidgeon	pidgeon	PROPN
admet-929	434	14	.	.	PUNCT
admet-929	435	1	in	in	ADP
admet-929	435	2	vitro	vitro	X
admet-929	435	3	membrane	membrane	NOUN
admet-929	435	4	binding	bind	VERB
admet-929	435	5	and	and	CCONJ
admet-929	435	6	protein	protein	NOUN
admet-929	435	7	binding	bind	VERB
admet-929	435	8	(	(	PUNCT
admet-929	435	9	iam	iam	PROPN
admet-929	435	10	mb	mb	PROPN
admet-929	435	11	/	/	SYM
admet-929	435	12	pb	pb	X
admet-929	435	13	technology	technology	NOUN
admet-929	435	14	)	)	PUNCT
admet-929	435	15	to	to	PART
admet-929	435	16	estimate	estimate	VERB
admet-929	435	17	in	in	ADP
admet-929	435	18	vivo	vivo	ADJ
admet-929	435	19	distribution	distribution	NOUN
admet-929	435	20	:	:	PUNCT
admet-929	435	21	applications	application	NOUN
admet-929	435	22	in	in	ADP
admet-929	435	23	early	early	ADJ
admet-929	435	24	drug	drug	NOUN
admet-929	435	25	discovery	discovery	NOUN
admet-929	435	26	.	.	PUNCT
admet-929	436	1	admet	admet	PROPN
admet-929	436	2	dmpk	dmpk	PROPN
admet-929	436	3	5	5	NUM
admet-929	436	4	(	(	PUNCT
admet-929	436	5	2017	2017	NUM
admet-929	436	6	)	)	PUNCT
admet-929	436	7	14	14	NUM
admet-929	436	8	.	.	PUNCT
admet-929	437	1	doi	doi	NOUN
admet-929	437	2	:	:	PUNCT
admet-929	437	3	https://doi.org/10.5599/admet.5.1.373	https://doi.org/10.5599/admet.5.1.373	PROPN
admet-929	437	4	.	.	PUNCT
admet-929	438	1	[	[	X
admet-929	438	2	27	27	NUM
admet-929	438	3	]	]	X
admet-929	438	4	k.l	k.l	PROPN
admet-929	438	5	.	.	PROPN
admet-929	438	6	valkó	valkó	PROPN
admet-929	438	7	,	,	PUNCT
admet-929	438	8	s.b	s.b	PROPN
admet-929	438	9	.	.	PROPN
admet-929	438	10	nunhuck	nunhuck	PROPN
admet-929	438	11	,	,	PUNCT
admet-929	438	12	a.p	a.p	PROPN
admet-929	438	13	.	.	PROPN
admet-929	438	14	hill	hill	PROPN
admet-929	438	15	.	.	PUNCT
admet-929	439	1	estimating	estimate	VERB
admet-929	439	2	unbound	unbound	NOUN
admet-929	439	3	volume	volume	NOUN
admet-929	439	4	of	of	ADP
admet-929	439	5	distribution	distribution	NOUN
admet-929	439	6	and	and	CCONJ
admet-929	439	7	tissue	tissue	NOUN
admet-929	439	8	binding	bind	VERB
admet-929	439	9	by	by	ADP
admet-929	439	10	in	in	ADP
admet-929	439	11	vitro	vitro	X
admet-929	439	12	hplc	hplc	NOUN
admet-929	439	13	-	-	PUNCT
admet-929	439	14	based	base	VERB
admet-929	439	15	human	human	ADJ
admet-929	439	16	serum	serum	NOUN
admet-929	439	17	albumin	albumin	NOUN
admet-929	439	18	and	and	CCONJ
admet-929	439	19	immobilized	immobilize	VERB
admet-929	439	20	artificial	artificial	ADJ
admet-929	439	21	membrane	membrane	NOUN
admet-929	439	22	-	-	PUNCT
admet-929	439	23	binding	bind	VERB
admet-929	439	24	measurements	measurement	NOUN
admet-929	439	25	.	.	PUNCT
admet-929	440	1	j.	j.	PROPN
admet-929	440	2	pharm	pharm	PROPN
admet-929	440	3	.	.	PUNCT
admet-929	441	1	sci	sci	PROPN
admet-929	441	2	.	.	PROPN
admet-929	441	3	100	100	NUM
admet-929	441	4	(	(	PUNCT
admet-929	441	5	2011	2011	NUM
admet-929	441	6	)	)	PUNCT
admet-929	441	7	849–862	849–862	NUM
admet-929	441	8	.	.	PUNCT
admet-929	442	1	doi	doi	NOUN
admet-929	442	2	:	:	PUNCT
admet-929	442	3	https://doi.org/10.1002/jps.22323	https://doi.org/10.1002/jps.22323	NOUN
admet-929	442	4	.	.	PUNCT
admet-929	443	1	[	[	X
admet-929	443	2	28	28	NUM
admet-929	443	3	]	]	X
admet-929	443	4	k.	k.	PROPN
admet-929	443	5	valko	valko	PROPN
admet-929	443	6	.	.	PUNCT
admet-929	444	1	lipophilicity	lipophilicity	PROPN
admet-929	444	2	and	and	CCONJ
admet-929	444	3	biomimetic	biomimetic	ADJ
admet-929	444	4	properties	property	NOUN
admet-929	444	5	measured	measure	VERB
admet-929	444	6	by	by	ADP
admet-929	444	7	hplc	hplc	NOUN
admet-929	444	8	to	to	PART
admet-929	444	9	support	support	VERB
admet-929	444	10	drug	drug	NOUN
admet-929	444	11	discovery	discovery	NOUN
admet-929	444	12	.	.	PUNCT
admet-929	445	1	j.	j.	PROPN
admet-929	445	2	pharm	pharm	PROPN
admet-929	445	3	.	.	PUNCT
admet-929	445	4	biomed	biome	VERB
admet-929	445	5	.	.	PUNCT
admet-929	446	1	anal	anal	ADJ
admet-929	446	2	.	.	PUNCT
admet-929	447	1	130	130	NUM
admet-929	447	2	(	(	PUNCT
admet-929	447	3	2016	2016	NUM
admet-929	447	4	)	)	PUNCT
admet-929	447	5	35–54	35–54	NUM
admet-929	447	6	.	.	PUNCT
admet-929	447	7	doi	doi	NOUN
admet-929	447	8	:	:	PUNCT
admet-929	447	9	https://doi.org/10.1016/j.jpba.2016.04.009	https://doi.org/10.1016/j.jpba.2016.04.009	PROPN
admet-929	447	10	.	.	PROPN
admet-929	447	11	https://doi.org/10.5599/admet.929	https://doi.org/10.5599/admet.929	PROPN
admet-929	447	12	https://doi.org/10.1097/00007691-198612000-00014	https://doi.org/10.1097/00007691-198612000-00014	VERB
admet-929	448	1	https://doi.org/10.1111/j.1365-2125.1995.tb05768.x	https://doi.org/10.1111/j.1365-2125.1995.tb05768.x	PROPN
admet-929	448	2	https://doi.org/10.1016/j.drudis.2020.04.021	https://doi.org/10.1016/j.drudis.2020.04.021	PROPN
admet-929	448	3	https://doi.org/10.1016/j.drudis.2020.04.021	https://doi.org/10.1016/j.drudis.2020.04.021	NOUN
admet-929	449	1	https://doi.org/10.1016/0378-4347(92)80126-b	https://doi.org/10.1016/0378-4347(92)80126-b	ADJ
admet-929	449	2	https://doi.org/10.1111/j.1365-2125.1983.tb01513.x	https://doi.org/10.1111/j.1365-2125.1983.tb01513.x	PROPN
admet-929	450	1	https://doi.org/10.1111/j.1365-2125.1983.tb01513.x	https://doi.org/10.1111/j.1365-2125.1983.tb01513.x	PROPN
admet-929	450	2	https://doi.org/10.1111/j.1365-2125.1986.tb02900.x	https://doi.org/10.1111/j.1365-2125.1986.tb02900.x	PROPN
admet-929	450	3	https://doi.org/10.1111/j.1365-2125.1986.tb02900.x	https://doi.org/10.1111/j.1365-2125.1986.tb02900.x	PROPN
admet-929	451	1	https://doi.org/10.1111/j.1365-2125.1993.tb05897.x	https://doi.org/10.1111/j.1365-2125.1993.tb05897.x	INTJ
admet-929	451	2	https://doi.org/10.1016/0731-7085(90)80074-y	https://doi.org/10.1016/0731-7085(90)80074-y	PROPN
admet-929	451	3	https://doi.org/10.1016/0731-7085(90)80074-y	https://doi.org/10.1016/0731-7085(90)80074-y	PROPN
admet-929	451	4	https://doi.org/10.1002/chir.530040108	https://doi.org/10.1002/chir.530040108	VERB
admet-929	451	5	https://doi.org/10.1101/2020.05.26.114033	https://doi.org/10.1101/2020.05.26.114033	PROPN
admet-929	451	6	https://search.daicelchiral.com/	https://search.daicelchiral.com/	NOUN
admet-929	451	7	https://doi.org/10.5599/admet.5.1.373	https://doi.org/10.5599/admet.5.1.373	PROPN
admet-929	451	8	https://doi.org/10.1002/jps.22323	https://doi.org/10.1002/jps.22323	PROPN
admet-929	451	9	https://doi.org/10.1016/j.jpba.2016.04.009	https://doi.org/10.1016/j.jpba.2016.04.009	PROPN
admet-929	451	10	klara	klara	PROPN
admet-929	451	11	valko	valko	PROPN
admet-929	451	12	and	and	CCONJ
admet-929	451	13	tong	tong	PROPN
admet-929	451	14	zhang	zhang	PROPN
admet-929	451	15	admet	admet	PROPN
admet-929	451	16	&	&	CCONJ
admet-929	451	17	dmpk	dmpk	PROPN
admet-929	451	18	9(2	9(2	NUM
admet-929	451	19	)	)	PUNCT
admet-929	451	20	(	(	PUNCT
admet-929	451	21	2021	2021	NUM
admet-929	451	22	)	)	PUNCT
admet-929	451	23	151	151	NUM
admet-929	451	24	-	-	SYM
admet-929	451	25	165	165	NUM
admet-929	451	26	164	164	NUM
admet-929	451	27	[	[	X
admet-929	452	1	29	29	NUM
admet-929	452	2	]	]	PUNCT
admet-929	452	3	k.	k.	PROPN
admet-929	452	4	valko	valko	PROPN
admet-929	452	5	,	,	PUNCT
admet-929	452	6	c.	c.	PROPN
admet-929	452	7	du	du	PROPN
admet-929	452	8	,	,	PUNCT
admet-929	452	9	c.	c.	PROPN
admet-929	452	10	bevan	bevan	PROPN
admet-929	452	11	,	,	PUNCT
admet-929	452	12	d.	d.	PROPN
admet-929	452	13	reynolds	reynolds	PROPN
admet-929	452	14	,	,	PUNCT
admet-929	452	15	m.	m.	PROPN
admet-929	452	16	abraham	abraham	PROPN
admet-929	452	17	.	.	PUNCT
admet-929	453	1	rapid	rapid	ADJ
admet-929	453	2	method	method	NOUN
admet-929	453	3	for	for	ADP
admet-929	453	4	the	the	DET
admet-929	453	5	estimation	estimation	NOUN
admet-929	453	6	of	of	ADP
admet-929	453	7	octanol	octanol	NOUN
admet-929	453	8	/	/	SYM
admet-929	453	9	water	water	NOUN
admet-929	453	10	partition	partition	NOUN
admet-929	453	11	coefficient	coefficient	NOUN
admet-929	453	12	(	(	PUNCT
admet-929	453	13	log	log	PROPN
admet-929	453	14	poct	poct	PROPN
admet-929	453	15	)	)	PUNCT
admet-929	453	16	from	from	ADP
admet-929	453	17	gradient	gradient	ADJ
admet-929	453	18	rp	rp	NOUN
admet-929	453	19	-	-	PUNCT
admet-929	453	20	hplc	hplc	NOUN
admet-929	453	21	retention	retention	NOUN
admet-929	453	22	and	and	CCONJ
admet-929	453	23	a	a	DET
admet-929	453	24	hydrogen	hydrogen	NOUN
admet-929	453	25	bond	bond	NOUN
admet-929	453	26	acidity	acidity	NOUN
admet-929	453	27	term	term	NOUN
admet-929	453	28	(	(	PUNCT
admet-929	453	29	sigma	sigma	NOUN
admet-929	453	30	alpha2h	alpha2h	ADV
admet-929	453	31	)	)	PUNCT
admet-929	453	32	.	.	PUNCT
admet-929	454	1	curr	curr	AUX
admet-929	454	2	.	.	PUNCT
admet-929	454	3	med	med	PROPN
admet-929	454	4	.	.	PROPN
admet-929	454	5	chem	chem	PROPN
admet-929	454	6	.	.	PUNCT
admet-929	455	1	8	8	NUM
admet-929	455	2	(	(	PUNCT
admet-929	455	3	2001	2001	NUM
admet-929	455	4	)	)	PUNCT
admet-929	455	5	1137–1146	1137–1146	NUM
admet-929	455	6	.	.	PUNCT
admet-929	456	1	doi	doi	NOUN
admet-929	456	2	:	:	PUNCT
admet-929	456	3	https://doi.org/10.2174/0929867013372643	https://doi.org/10.2174/0929867013372643	PROPN
admet-929	456	4	.	.	PUNCT
admet-929	457	1	[	[	X
admet-929	457	2	30	30	NUM
admet-929	457	3	]	]	PUNCT
admet-929	457	4	k.	k.	PROPN
admet-929	457	5	valko	valko	PROPN
admet-929	457	6	,	,	PUNCT
admet-929	457	7	s.	s.	PROPN
admet-929	457	8	nunhuck	nunhuck	PROPN
admet-929	457	9	,	,	PUNCT
admet-929	457	10	c.	c.	PROPN
admet-929	457	11	bevan	bevan	PROPN
admet-929	457	12	,	,	PUNCT
admet-929	457	13	m.	m.	PROPN
admet-929	457	14	abraham	abraham	PROPN
admet-929	457	15	,	,	PUNCT
admet-929	457	16	d.	d.	PROPN
admet-929	457	17	reynolds	reynolds	PROPN
admet-929	457	18	.	.	PUNCT
admet-929	458	1	fast	fast	PROPN
admet-929	458	2	gradient	gradient	NOUN
admet-929	458	3	hplc	hplc	NOUN
admet-929	458	4	method	method	NOUN
admet-929	458	5	to	to	PART
admet-929	458	6	determine	determine	VERB
admet-929	458	7	compounds	compound	NOUN
admet-929	458	8	binding	bind	VERB
admet-929	458	9	to	to	ADP
admet-929	458	10	human	human	ADJ
admet-929	458	11	serum	serum	NOUN
admet-929	458	12	albumin	albumin	PROPN
admet-929	458	13	.	.	PUNCT
admet-929	459	1	relationship	relationship	NOUN
admet-929	459	2	wth	wth	PROPN
admet-929	459	3	octanol	octanol	NOUN
admet-929	459	4	water	water	NOUN
admet-929	459	5	and	and	CCONJ
admet-929	459	6	immobilized	immobilize	VERB
admet-929	459	7	artificial	artificial	ADJ
admet-929	459	8	membrane	membrane	NOUN
admet-929	459	9	lipophilicity	lipophilicity	NOUN
admet-929	459	10	.	.	PUNCT
admet-929	460	1	j.	j.	PROPN
admet-929	460	2	pharm	pharm	PROPN
admet-929	460	3	.	.	PUNCT
admet-929	461	1	sci	sci	PROPN
admet-929	461	2	.	.	PROPN
admet-929	462	1	92	92	NUM
admet-929	462	2	(	(	PUNCT
admet-929	462	3	2003	2003	NUM
admet-929	462	4	)	)	PUNCT
admet-929	462	5	2236–2248	2236–2248	NUM
admet-929	462	6	.	.	PUNCT
admet-929	463	1	doi	doi	NOUN
admet-929	463	2	:	:	PUNCT
admet-929	464	1	https://doi.org/10.1002/jps.10494	https://doi.org/10.1002/jps.10494	ADJ
admet-929	464	2	.	.	PUNCT
admet-929	465	1	[	[	X
admet-929	465	2	31	31	NUM
admet-929	465	3	]	]	PUNCT
admet-929	465	4	k.	k.	PROPN
admet-929	465	5	valko	valko	PROPN
admet-929	465	6	.	.	PUNCT
admet-929	466	1	physicochemical	physicochemical	ADJ
admet-929	466	2	and	and	CCONJ
admet-929	466	3	biomimetic	biomimetic	ADJ
admet-929	466	4	properties	property	NOUN
admet-929	466	5	in	in	ADP
admet-929	466	6	drug	drug	NOUN
admet-929	466	7	discovery	discovery	NOUN
admet-929	466	8	chromatographic	chromatographic	ADJ
admet-929	466	9	techniques	technique	NOUN
admet-929	466	10	for	for	ADP
admet-929	466	11	lead	lead	ADJ
admet-929	466	12	optimization	optimization	NOUN
admet-929	466	13	.	.	PUNCT
admet-929	467	1	wiley	wiley	PROPN
admet-929	467	2	,	,	PUNCT
admet-929	467	3	hoboken	hoboken	PROPN
admet-929	467	4	,	,	PUNCT
admet-929	467	5	nj	nj	PROPN
admet-929	467	6	,	,	PUNCT
admet-929	467	7	usa	usa	PROPN
admet-929	467	8	,	,	PUNCT
admet-929	467	9	2014	2014	NUM
admet-929	467	10	.	.	PUNCT
admet-929	468	1	[	[	X
admet-929	468	2	32	32	NUM
admet-929	468	3	]	]	PUNCT
admet-929	468	4	c.	c.	PROPN
admet-929	468	5	hansch	hansch	PROPN
admet-929	468	6	,	,	PUNCT
admet-929	468	7	a.	a.	PROPN
admet-929	468	8	leo	leo	PROPN
admet-929	468	9	.	.	PUNCT
admet-929	469	1	exploring	explore	VERB
admet-929	469	2	qsar	qsar	NOUN
admet-929	469	3	:	:	PUNCT
admet-929	469	4	hydrophobic	hydrophobic	NOUN
admet-929	469	5	,	,	PUNCT
admet-929	469	6	electronic	electronic	ADJ
admet-929	469	7	,	,	PUNCT
admet-929	469	8	and	and	CCONJ
admet-929	469	9	steric	steric	ADJ
admet-929	469	10	constants	constant	NOUN
admet-929	469	11	.	.	PUNCT
admet-929	470	1	american	american	ADJ
admet-929	470	2	chemical	chemical	PROPN
admet-929	470	3	society	society	PROPN
admet-929	470	4	,	,	PUNCT
admet-929	470	5	washington	washington	PROPN
admet-929	470	6	,	,	PUNCT
admet-929	470	7	dc	dc	PROPN
admet-929	470	8	.	.	PROPN
admet-929	470	9	,	,	PUNCT
admet-929	470	10	1995	1995	NUM
admet-929	470	11	.	.	PUNCT
admet-929	471	1	[	[	X
admet-929	471	2	33	33	NUM
admet-929	471	3	]	]	X
admet-929	471	4	d.c	d.c	PROPN
admet-929	471	5	.	.	PROPN
admet-929	471	6	warhurst	warhurst	PROPN
admet-929	471	7	,	,	PUNCT
admet-929	471	8	j.c.p	j.c.p	PROPN
admet-929	471	9	.	.	PUNCT
admet-929	472	1	steele	steele	PROPN
admet-929	472	2	,	,	PUNCT
admet-929	473	1	i.s	i.s	PROPN
admet-929	473	2	.	.	PROPN
admet-929	473	3	adagu	adagu	PROPN
admet-929	473	4	,	,	PUNCT
admet-929	473	5	j.c	j.c	PROPN
admet-929	473	6	.	.	PROPN
admet-929	473	7	craig	craig	PROPN
admet-929	473	8	,	,	PUNCT
admet-929	473	9	c.	c.	PROPN
admet-929	473	10	cullander	cullander	NOUN
admet-929	473	11	.	.	PUNCT
admet-929	474	1	hydroxychloroquine	hydroxychloroquine	PROPN
admet-929	474	2	is	be	AUX
admet-929	474	3	much	much	ADV
admet-929	474	4	less	less	ADV
admet-929	474	5	active	active	ADJ
admet-929	474	6	than	than	ADP
admet-929	474	7	chloroquine	chloroquine	NOUN
admet-929	474	8	against	against	ADP
admet-929	474	9	chloroquine	chloroquine	NOUN
admet-929	474	10	-	-	PUNCT
admet-929	474	11	resistant	resistant	ADJ
admet-929	474	12	plasmodium	plasmodium	NOUN
admet-929	474	13	falciparum	falciparum	NOUN
admet-929	474	14	,	,	PUNCT
admet-929	474	15	in	in	ADP
admet-929	474	16	agreement	agreement	NOUN
admet-929	474	17	with	with	ADP
admet-929	474	18	its	its	PRON
admet-929	474	19	physicochemical	physicochemical	ADJ
admet-929	474	20	properties	property	NOUN
admet-929	474	21	.	.	PUNCT
admet-929	475	1	j.	j.	PROPN
admet-929	475	2	antimicrob	antimicrob	PROPN
admet-929	475	3	.	.	PUNCT
admet-929	476	1	chemother	chemother	PROPN
admet-929	476	2	.	.	PUNCT
admet-929	477	1	52	52	NUM
admet-929	477	2	(	(	PUNCT
admet-929	477	3	2003	2003	NUM
admet-929	477	4	)	)	PUNCT
admet-929	478	1	188–193	188–193	NUM
admet-929	478	2	.	.	PUNCT
admet-929	479	1	doi	doi	PROPN
admet-929	479	2	:	:	PUNCT
admet-929	479	3	https://doi.org/10.1093/jac/dkg319	https://doi.org/10.1093/jac/dkg319	PROPN
admet-929	479	4	.	.	PUNCT
admet-929	480	1	[	[	X
admet-929	480	2	34	34	NUM
admet-929	480	3	]	]	PUNCT
admet-929	480	4	z.	z.	PROPN
admet-929	480	5	jiang	jiang	PROPN
admet-929	480	6	,	,	PUNCT
admet-929	480	7	j.	j.	PROPN
admet-929	480	8	reilly	reilly	PROPN
admet-929	480	9	.	.	PUNCT
admet-929	481	1	chromatography	chromatography	NOUN
admet-929	481	2	approaches	approach	VERB
admet-929	481	3	for	for	ADP
admet-929	481	4	early	early	ADJ
admet-929	481	5	screening	screening	NOUN
admet-929	481	6	of	of	ADP
admet-929	481	7	the	the	DET
admet-929	481	8	phospholipidosis	phospholipidosis	NOUN
admet-929	481	9	-	-	PUNCT
admet-929	481	10	inducing	induce	VERB
admet-929	481	11	potential	potential	NOUN
admet-929	481	12	of	of	ADP
admet-929	481	13	pharmaceuticals	pharmaceutical	NOUN
admet-929	481	14	.	.	PUNCT
admet-929	482	1	j.	j.	PROPN
admet-929	482	2	pharm	pharm	PROPN
admet-929	482	3	.	.	PUNCT
admet-929	482	4	biomed	biome	VERB
admet-929	482	5	.	.	PUNCT
admet-929	483	1	anal	anal	ADJ
admet-929	483	2	.	.	PUNCT
admet-929	484	1	61	61	NUM
admet-929	484	2	(	(	PUNCT
admet-929	484	3	2012	2012	NUM
admet-929	484	4	)	)	PUNCT
admet-929	485	1	184–190	184–190	NUM
admet-929	485	2	.	.	PUNCT
admet-929	486	1	doi	doi	NOUN
admet-929	486	2	:	:	PUNCT
admet-929	486	3	https://doi.org/10.1016/j.jpba.2011.11.033	https://doi.org/10.1016/j.jpba.2011.11.033	NOUN
admet-929	486	4	.	.	PUNCT
admet-929	487	1	[	[	X
admet-929	487	2	35	35	NUM
admet-929	487	3	]	]	X
admet-929	487	4	z.	z.	PROPN
admet-929	487	5	yu	yu	PROPN
admet-929	487	6	,	,	PUNCT
admet-929	487	7	a.p	a.p	PROPN
admet-929	487	8	.	.	PROPN
admet-929	487	9	ijzerman	ijzerman	PROPN
admet-929	487	10	,	,	PUNCT
admet-929	487	11	l.h	l.h	PROPN
admet-929	487	12	.	.	PROPN
admet-929	487	13	heitman	heitman	NOUN
admet-929	487	14	.	.	PUNCT
admet-929	488	1	kv11.1	kv11.1	NOUN
admet-929	488	2	(	(	PUNCT
admet-929	488	3	herg)-induced	herg)-induced	ADJ
admet-929	488	4	cardiotoxicity	cardiotoxicity	NOUN
admet-929	488	5	:	:	PUNCT
admet-929	488	6	a	a	DET
admet-929	488	7	molecular	molecular	ADJ
admet-929	488	8	insight	insight	NOUN
admet-929	488	9	from	from	ADP
admet-929	488	10	a	a	DET
admet-929	488	11	binding	bind	VERB
admet-929	488	12	kinetics	kinetic	NOUN
admet-929	488	13	study	study	NOUN
admet-929	488	14	of	of	ADP
admet-929	488	15	prototypical	prototypical	ADJ
admet-929	488	16	kv11.1	kv11.1	NOUN
admet-929	488	17	(	(	PUNCT
admet-929	488	18	herg	herg	PROPN
admet-929	488	19	)	)	PUNCT
admet-929	488	20	inhibitors	inhibitor	NOUN
admet-929	488	21	.	.	PUNCT
admet-929	489	1	br	br	X
admet-929	489	2	.	.	PUNCT
admet-929	490	1	j.	j.	PROPN
admet-929	490	2	pharmacol	pharmacol	PROPN
admet-929	490	3	.	.	PUNCT
admet-929	491	1	172	172	NUM
admet-929	491	2	(	(	PUNCT
admet-929	491	3	2015	2015	NUM
admet-929	491	4	)	)	PUNCT
admet-929	492	1	940–955	940–955	NUM
admet-929	492	2	.	.	PUNCT
admet-929	493	1	doi	doi	NOUN
admet-929	493	2	:	:	PUNCT
admet-929	493	3	https://doi.org/10.1111/bph.12967	https://doi.org/10.1111/bph.12967	PROPN
admet-929	493	4	.	.	PUNCT
admet-929	494	1	[	[	X
admet-929	494	2	36	36	NUM
admet-929	494	3	]	]	X
admet-929	494	4	f.	f.	PROPN
admet-929	494	5	barbato	barbato	PROPN
admet-929	494	6	,	,	PUNCT
admet-929	494	7	v.	v.	ADP
admet-929	494	8	cirocco	cirocco	PROPN
admet-929	494	9	,	,	PUNCT
admet-929	494	10	l.	l.	PROPN
admet-929	494	11	grumetto	grumetto	PROPN
admet-929	494	12	,	,	PUNCT
admet-929	494	13	m.	m.	NOUN
admet-929	494	14	immacolata	immacolata	VERB
admet-929	494	15	la	la	PROPN
admet-929	494	16	rotonda	rotonda	PROPN
admet-929	494	17	.	.	PUNCT
admet-929	495	1	comparison	comparison	NOUN
admet-929	495	2	between	between	ADP
admet-929	495	3	immobilized	immobilized	ADJ
admet-929	495	4	artificial	artificial	ADJ
admet-929	495	5	membrane	membrane	NOUN
admet-929	495	6	(	(	PUNCT
admet-929	495	7	iam	iam	PROPN
admet-929	495	8	)	)	PUNCT
admet-929	495	9	hplc	hplc	NOUN
admet-929	495	10	data	datum	NOUN
admet-929	495	11	and	and	CCONJ
admet-929	495	12	lipophilicity	lipophilicity	NOUN
admet-929	495	13	in	in	ADP
admet-929	495	14	n	n	NOUN
admet-929	495	15	-	-	PUNCT
admet-929	495	16	octanol	octanol	NOUN
admet-929	495	17	for	for	ADP
admet-929	495	18	quinolone	quinolone	ADJ
admet-929	495	19	antibacterial	antibacterial	ADJ
admet-929	495	20	agents	agent	NOUN
admet-929	495	21	.	.	PUNCT
admet-929	496	1	eur	eur	PROPN
admet-929	496	2	.	.	PUNCT
admet-929	497	1	j.	j.	PROPN
admet-929	497	2	pharm	pharm	PROPN
admet-929	497	3	.	.	PUNCT
admet-929	498	1	sci	sci	PROPN
admet-929	498	2	.	.	PROPN
admet-929	499	1	31	31	NUM
admet-929	500	1	(	(	PUNCT
admet-929	500	2	2007	2007	NUM
admet-929	500	3	)	)	PUNCT
admet-929	500	4	288–297	288–297	NUM
admet-929	500	5	.	.	PUNCT
admet-929	501	1	doi	doi	NOUN
admet-929	501	2	:	:	PUNCT
admet-929	501	3	https://doi.org/10.1016/j.ejps.2007.04.003	https://doi.org/10.1016/j.ejps.2007.04.003	NOUN
admet-929	501	4	.	.	PUNCT
admet-929	502	1	[	[	X
admet-929	502	2	37	37	NUM
admet-929	502	3	]	]	X
admet-929	502	4	r.	r.	PROPN
admet-929	502	5	kaliszan	kaliszan	PROPN
admet-929	502	6	,	,	PUNCT
admet-929	502	7	a.	a.	NOUN
admet-929	502	8	nasal	nasal	PROPN
admet-929	502	9	,	,	PUNCT
admet-929	502	10	m.	m.	NOUN
admet-929	502	11	turowski	turowski	PROPN
admet-929	502	12	.	.	PUNCT
admet-929	503	1	binding	bind	VERB
admet-929	503	2	-	-	PUNCT
admet-929	503	3	site	site	NOUN
admet-929	503	4	for	for	ADP
admet-929	503	5	basic	basic	ADJ
admet-929	503	6	drugs	drug	NOUN
admet-929	503	7	on	on	ADP
admet-929	503	8	alpha(1)-acid	alpha(1)-acid	PUNCT
admet-929	503	9	glycoprotein	glycoprotein	NOUN
admet-929	503	10	as	as	SCONJ
admet-929	503	11	revealed	reveal	VERB
admet-929	503	12	by	by	ADP
admet-929	503	13	chemometric	chemometric	ADJ
admet-929	503	14	analysis	analysis	NOUN
admet-929	503	15	of	of	ADP
admet-929	503	16	biochromatographic	biochromatographic	ADJ
admet-929	503	17	data	datum	NOUN
admet-929	503	18	.	.	PUNCT
admet-929	503	19	biomed	biome	VERB
admet-929	503	20	.	.	PUNCT
admet-929	504	1	chromatogr	chromatogr	NOUN
admet-929	504	2	.	.	PUNCT
admet-929	505	1	9	9	NUM
admet-929	505	2	(	(	PUNCT
admet-929	505	3	1995	1995	NUM
admet-929	505	4	)	)	PUNCT
admet-929	505	5	211	211	NUM
admet-929	505	6	–	–	PUNCT
admet-929	505	7	215	215	NUM
admet-929	505	8	.	.	PUNCT
admet-929	506	1	doi	doi	NOUN
admet-929	506	2	:	:	PUNCT
admet-929	506	3	https:/doi.org/10.1002	https:/doi.org/10.1002	NOUN
admet-929	506	4	/	/	SYM
admet-929	506	5	bmc.1130090504	bmc.1130090504	ADJ
admet-929	506	6	.	.	PUNCT
admet-929	507	1	[	[	X
admet-929	507	2	38	38	NUM
admet-929	507	3	]	]	X
admet-929	507	4	z.h	z.h	PROPN
admet-929	507	5	.	.	PROPN
admet-929	507	6	israili	israili	PROPN
admet-929	507	7	,	,	PUNCT
admet-929	507	8	p.g	p.g	PROPN
admet-929	507	9	.	.	PROPN
admet-929	507	10	dayton	dayton	PROPN
admet-929	507	11	.	.	PUNCT
admet-929	508	1	human	human	ADJ
admet-929	508	2	alpha	alpha	NOUN
admet-929	508	3	1	1	NUM
admet-929	508	4	-	-	PUNCT
admet-929	508	5	acid	acid	NOUN
admet-929	508	6	glycoprotein	glycoprotein	NOUN
admet-929	508	7	and	and	CCONJ
admet-929	508	8	its	its	PRON
admet-929	508	9	interactions	interaction	NOUN
admet-929	508	10	with	with	ADP
admet-929	508	11	drugs	drug	NOUN
admet-929	508	12	.	.	PUNCT
admet-929	509	1	drug	drug	NOUN
admet-929	509	2	metab	metab	PROPN
admet-929	509	3	.	.	PUNCT
admet-929	510	1	rev	rev	PROPN
admet-929	510	2	.	.	PROPN
admet-929	511	1	33	33	NUM
admet-929	511	2	(	(	PUNCT
admet-929	511	3	2001	2001	NUM
admet-929	511	4	)	)	PUNCT
admet-929	512	1	161–235	161–235	NUM
admet-929	512	2	.	.	PUNCT
admet-929	513	1	doi	doi	NOUN
admet-929	513	2	:	:	PUNCT
admet-929	513	3	https:/doi.org/10.1081	https:/doi.org/10.1081	ADJ
admet-929	513	4	/	/	SYM
admet-929	513	5	dmr-100104402	dmr-100104402	NOUN
admet-929	513	6	.	.	PUNCT
admet-929	514	1	[	[	X
admet-929	514	2	39	39	NUM
admet-929	514	3	]	]	PUNCT
admet-929	514	4	f.	f.	PROPN
admet-929	514	5	hollosy	hollosy	PROPN
admet-929	514	6	,	,	PUNCT
admet-929	514	7	k.	k.	PROPN
admet-929	514	8	valko	valko	PROPN
admet-929	514	9	,	,	PUNCT
admet-929	514	10	a.	a.	PROPN
admet-929	514	11	hersey	hersey	PROPN
admet-929	514	12	,	,	PUNCT
admet-929	514	13	s.	s.	PROPN
admet-929	514	14	nunhuck	nunhuck	PROPN
admet-929	514	15	,	,	PUNCT
admet-929	514	16	g.	g.	PROPN
admet-929	514	17	keri	keri	PROPN
admet-929	514	18	,	,	PUNCT
admet-929	514	19	c.	c.	PROPN
admet-929	514	20	bevan	bevan	PROPN
admet-929	514	21	.	.	PUNCT
admet-929	515	1	estimation	estimation	NOUN
admet-929	515	2	of	of	ADP
admet-929	515	3	volume	volume	NOUN
admet-929	515	4	of	of	ADP
admet-929	515	5	distribution	distribution	NOUN
admet-929	515	6	in	in	ADP
admet-929	515	7	humans	human	NOUN
admet-929	515	8	from	from	ADP
admet-929	515	9	hplc	hplc	NOUN
admet-929	515	10	measurements	measurement	NOUN
admet-929	515	11	of	of	ADP
admet-929	515	12	human	human	ADJ
admet-929	515	13	serum	serum	NOUN
admet-929	515	14	albumin	albumin	NOUN
admet-929	515	15	binding	bind	VERB
admet-929	515	16	and	and	CCONJ
admet-929	515	17	immobilized	immobilize	VERB
admet-929	515	18	artificial	artificial	ADJ
admet-929	515	19	membrane	membrane	NOUN
admet-929	515	20	partitioning	partitioning	NOUN
admet-929	515	21	.	.	PUNCT
admet-929	516	1	j.	j.	PROPN
admet-929	516	2	med	med	PROPN
admet-929	516	3	.	.	PROPN
admet-929	516	4	chem	chem	PROPN
admet-929	516	5	.	.	PUNCT
admet-929	517	1	49	49	NUM
admet-929	517	2	(	(	PUNCT
admet-929	517	3	2006	2006	NUM
admet-929	517	4	)	)	PUNCT
admet-929	517	5	6958–6971	6958–6971	NUM
admet-929	517	6	.	.	PUNCT
admet-929	518	1	doi	doi	NOUN
admet-929	518	2	:	:	PUNCT
admet-929	518	3	https://doi.org/10.1021/jm050957i	https://doi.org/10.1021/jm050957i	PROPN
admet-929	518	4	.	.	PUNCT
admet-929	519	1	[	[	X
admet-929	519	2	40	40	NUM
admet-929	519	3	]	]	X
admet-929	519	4	j.a	j.a	PROPN
admet-929	519	5	.	.	PROPN
admet-929	519	6	shayman	shayman	PROPN
admet-929	519	7	,	,	PUNCT
admet-929	519	8	a.	a.	PROPN
admet-929	519	9	abe	abe	PROPN
admet-929	519	10	.	.	PUNCT
admet-929	519	11	drug	drug	PROPN
admet-929	519	12	induced	induce	VERB
admet-929	519	13	phospholipidosis	phospholipidosis	NOUN
admet-929	519	14	:	:	PUNCT
admet-929	519	15	an	an	DET
admet-929	519	16	acquired	acquire	VERB
admet-929	519	17	lysosomal	lysosomal	ADJ
admet-929	519	18	storage	storage	NOUN
admet-929	519	19	disorder	disorder	NOUN
admet-929	519	20	.	.	PUNCT
admet-929	520	1	biochim	biochim	NOUN
admet-929	520	2	.	.	PUNCT
admet-929	521	1	biophys	biophy	NOUN
admet-929	521	2	.	.	PUNCT
admet-929	522	1	acta	acta	PROPN
admet-929	522	2	1831	1831	NUM
admet-929	522	3	(	(	PUNCT
admet-929	522	4	2013	2013	NUM
admet-929	522	5	)	)	PUNCT
admet-929	523	1	602–611	602–611	NUM
admet-929	523	2	.	.	PUNCT
admet-929	524	1	doi	doi	NOUN
admet-929	524	2	:	:	PUNCT
admet-929	524	3	https://doi.org/10.1016/j.bbalip.2012.08.013	https://doi.org/10.1016/j.bbalip.2012.08.013	PROPN
admet-929	524	4	.	.	PUNCT
admet-929	525	1	[	[	X
admet-929	525	2	41	41	NUM
admet-929	525	3	]	]	PUNCT
admet-929	525	4	j.	j.	PROPN
admet-929	525	5	müller	müller	PROPN
admet-929	525	6	-	-	PUNCT
admet-929	525	7	höcker	höcker	PROPN
admet-929	525	8	,	,	PUNCT
admet-929	525	9	h.	h.	PROPN
admet-929	525	10	schmid	schmid	PROPN
admet-929	525	11	,	,	PUNCT
admet-929	525	12	m.	m.	NOUN
admet-929	525	13	weiss	weiss	PROPN
admet-929	525	14	,	,	PUNCT
admet-929	525	15	u.	u.	NOUN
admet-929	525	16	dendorfer	dendorfer	PROPN
admet-929	525	17	,	,	PUNCT
admet-929	525	18	g.s	g.s	PROPN
admet-929	525	19	.	.	PROPN
admet-929	525	20	braun	braun	PROPN
admet-929	525	21	.	.	PUNCT
admet-929	526	1	chloroquine	chloroquine	NOUN
admet-929	526	2	-	-	PUNCT
admet-929	526	3	induced	induce	VERB
admet-929	526	4	phospholipidosis	phospholipidosis	NOUN
admet-929	526	5	of	of	ADP
admet-929	526	6	the	the	DET
admet-929	526	7	kidney	kidney	NOUN
admet-929	526	8	mimicking	mimic	VERB
admet-929	526	9	fabry	fabry	NOUN
admet-929	526	10	’s	’s	PART
admet-929	526	11	disease	disease	NOUN
admet-929	526	12	:	:	PUNCT
admet-929	526	13	case	case	NOUN
admet-929	526	14	report	report	NOUN
admet-929	526	15	and	and	CCONJ
admet-929	526	16	review	review	NOUN
admet-929	526	17	of	of	ADP
admet-929	526	18	the	the	DET
admet-929	526	19	literature	literature	NOUN
admet-929	526	20	.	.	PUNCT
admet-929	527	1	hum	hum	PROPN
admet-929	527	2	.	.	PUNCT
admet-929	528	1	pathol	pathol	NOUN
admet-929	528	2	.	.	PUNCT
admet-929	529	1	34	34	NUM
admet-929	529	2	(	(	PUNCT
admet-929	529	3	2003	2003	NUM
admet-929	529	4	)	)	PUNCT
admet-929	530	1	285–289	285–289	NUM
admet-929	530	2	.	.	PUNCT
admet-929	531	1	doi	doi	NOUN
admet-929	531	2	:	:	PUNCT
admet-929	532	1	https://doi.org/10.1053/hupa.2003.36	https://doi.org/10.1053/hupa.2003.36	ADJ
admet-929	532	2	.	.	PUNCT
admet-929	533	1	[	[	X
admet-929	533	2	42	42	NUM
admet-929	533	3	]	]	SYM
admet-929	533	4	j.-p.h.t.m	j.-p.h.t.m	X
admet-929	533	5	.	.	PUNCT
admet-929	533	6	ploemen	ploemen	PROPN
admet-929	533	7	,	,	PUNCT
admet-929	533	8	j.	j.	PROPN
admet-929	533	9	kelder	kelder	PROPN
admet-929	533	10	,	,	PUNCT
admet-929	533	11	t.	t.	PROPN
admet-929	533	12	hafmans	hafmans	PROPN
admet-929	533	13	,	,	PUNCT
admet-929	533	14	h.	h.	PROPN
admet-929	533	15	van	van	PROPN
admet-929	533	16	de	de	PROPN
admet-929	533	17	sandt	sandt	PROPN
admet-929	533	18	,	,	PUNCT
admet-929	533	19	j.a	j.a	PROPN
admet-929	533	20	.	.	PROPN
admet-929	533	21	van	van	PROPN
admet-929	533	22	burgsteden	burgsteden	PROPN
admet-929	533	23	,	,	PUNCT
admet-929	533	24	p.j.m	p.j.m	PROPN
admet-929	533	25	.	.	PROPN
admet-929	533	26	salemink	salemink	PROPN
admet-929	533	27	,	,	PUNCT
admet-929	533	28	e.	e.	PROPN
admet-929	533	29	van	van	PROPN
admet-929	533	30	esch	esch	PROPN
admet-929	533	31	.	.	PUNCT
admet-929	534	1	use	use	NOUN
admet-929	534	2	of	of	ADP
admet-929	534	3	physicochemical	physicochemical	ADJ
admet-929	534	4	calculation	calculation	NOUN
admet-929	534	5	of	of	ADP
admet-929	534	6	pka	pka	PROPN
admet-929	534	7	and	and	CCONJ
admet-929	534	8	clogp	clogp	VERB
admet-929	534	9	to	to	PART
admet-929	534	10	predict	predict	VERB
admet-929	534	11	phospholipidosis	phospholipidosis	NOUN
admet-929	534	12	-	-	PUNCT
admet-929	534	13	inducing	induce	VERB
admet-929	534	14	potential	potential	NOUN
admet-929	534	15	.	.	PUNCT
admet-929	535	1	exp	exp	NOUN
admet-929	535	2	.	.	PUNCT
admet-929	536	1	toxicol	toxicol	PROPN
admet-929	536	2	.	.	PUNCT
admet-929	537	1	pathol	pathol	PROPN
admet-929	537	2	.	.	PUNCT
admet-929	538	1	55	55	NUM
admet-929	538	2	(	(	PUNCT
admet-929	538	3	2004	2004	NUM
admet-929	538	4	)	)	PUNCT
admet-929	539	1	347–355	347–355	NUM
admet-929	539	2	.	.	PUNCT
admet-929	540	1	doi	doi	NOUN
admet-929	540	2	:	:	PUNCT
admet-929	540	3	https://doi.org/10.1078/0940-2993-00338	https://doi.org/10.1078/0940-2993-00338	PROPN
admet-929	540	4	.	.	PUNCT
admet-929	541	1	[	[	X
admet-929	541	2	43	43	NUM
admet-929	541	3	]	]	X
admet-929	541	4	f.	f.	PROPN
admet-929	541	5	hollósy	hollósy	PROPN
admet-929	541	6	,	,	PUNCT
admet-929	541	7	k.	k.	PROPN
admet-929	541	8	valkó	valkó	PROPN
admet-929	541	9	,	,	PUNCT
admet-929	541	10	a.	a.	NOUN
admet-929	541	11	hersey	hersey	PROPN
admet-929	541	12	,	,	PUNCT
admet-929	541	13	s.	s.	PROPN
admet-929	541	14	nunhuck	nunhuck	PROPN
admet-929	541	15	,	,	PUNCT
admet-929	541	16	g.	g.	PROPN
admet-929	541	17	kéri	kéri	PROPN
admet-929	541	18	,	,	PUNCT
admet-929	541	19	c.	c.	PROPN
admet-929	541	20	bevan	bevan	PROPN
admet-929	541	21	.	.	PUNCT
admet-929	542	1	estimation	estimation	NOUN
admet-929	542	2	of	of	ADP
admet-929	542	3	volume	volume	NOUN
admet-929	542	4	of	of	ADP
admet-929	542	5	distribution	distribution	NOUN
admet-929	542	6	in	in	ADP
admet-929	542	7	humans	human	NOUN
admet-929	542	8	from	from	ADP
admet-929	542	9	high	high	ADJ
admet-929	542	10	throughput	throughput	NOUN
admet-929	542	11	hplc	hplc	NOUN
admet-929	542	12	-	-	PUNCT
admet-929	542	13	based	base	VERB
admet-929	542	14	measurements	measurement	NOUN
admet-929	542	15	of	of	ADP
admet-929	542	16	human	human	ADJ
admet-929	542	17	serum	serum	NOUN
admet-929	542	18	albumin	albumin	NOUN
admet-929	542	19	binding	bind	VERB
admet-929	542	20	and	and	CCONJ
admet-929	542	21	immobilized	immobilize	VERB
admet-929	542	22	artificial	artificial	ADJ
admet-929	542	23	membrane	membrane	NOUN
admet-929	542	24	partitioning	partitioning	NOUN
admet-929	542	25	.	.	PUNCT
admet-929	543	1	j.	j.	PROPN
admet-929	543	2	med	med	PROPN
admet-929	543	3	.	.	PROPN
admet-929	543	4	chem	chem	PROPN
admet-929	543	5	.	.	PUNCT
admet-929	544	1	49	49	NUM
admet-929	544	2	(	(	PUNCT
admet-929	544	3	2006	2006	NUM
admet-929	544	4	)	)	PUNCT
admet-929	544	5	6958–71	6958–71	NOUN
admet-929	544	6	.	.	PUNCT
admet-929	545	1	doi	doi	NOUN
admet-929	545	2	:	:	PUNCT
admet-929	545	3	https://doi.org/10.1021/jm050957i	https://doi.org/10.1021/jm050957i	PROPN
admet-929	545	4	.	.	PUNCT
admet-929	546	1	[	[	X
admet-929	546	2	44	44	NUM
admet-929	546	3	]	]	PUNCT
admet-929	546	4	k.	k.	PROPN
admet-929	546	5	valko	valko	PROPN
admet-929	546	6	,	,	PUNCT
admet-929	546	7	s.	s.	PROPN
admet-929	546	8	rava	rava	PROPN
admet-929	546	9	,	,	PUNCT
admet-929	546	10	s.	s.	PROPN
admet-929	546	11	bunally	bunally	ADV
admet-929	546	12	,	,	PUNCT
admet-929	546	13	s.	s.	PROPN
admet-929	546	14	anderson	anderson	PROPN
admet-929	546	15	.	.	PUNCT
admet-929	547	1	revisiting	revisit	VERB
admet-929	547	2	the	the	DET
admet-929	547	3	application	application	NOUN
admet-929	547	4	of	of	ADP
admet-929	547	5	immobilized	immobilized	ADJ
admet-929	547	6	artificial	artificial	ADJ
admet-929	547	7	membrane	membrane	NOUN
admet-929	547	8	(	(	PUNCT
admet-929	547	9	iam	iam	PROPN
admet-929	547	10	)	)	PUNCT
admet-929	547	11	chromatography	chromatography	NOUN
admet-929	547	12	to	to	PART
admet-929	547	13	estimate	estimate	VERB
admet-929	547	14	in	in	ADP
admet-929	547	15	vivo	vivo	ADJ
admet-929	547	16	distribution	distribution	NOUN
admet-929	547	17	properties	property	NOUN
admet-929	547	18	of	of	ADP
admet-929	547	19	drug	drug	NOUN
admet-929	547	20	discovery	discovery	NOUN
admet-929	547	21	compounds	compound	NOUN
admet-929	547	22	based	base	VERB
admet-929	547	23	on	on	ADP
admet-929	547	24	the	the	DET
admet-929	547	25	model	model	NOUN
admet-929	547	26	of	of	ADP
admet-929	547	27	marketed	market	VERB
admet-929	547	28	drugs	drug	NOUN
admet-929	547	29	.	.	PUNCT
admet-929	548	1	admet	admet	PROPN
admet-929	548	2	dmpk	dmpk	PROPN
admet-929	548	3	8	8	NUM
admet-929	548	4	(	(	PUNCT
admet-929	548	5	2020	2020	NUM
admet-929	548	6	)	)	PUNCT
admet-929	549	1	78–97	78–97	NUM
admet-929	549	2	.	.	PUNCT
admet-929	550	1	doi	doi	NOUN
admet-929	550	2	:	:	PUNCT
admet-929	550	3	https://doi.org/10.5599/admet.757	https://doi.org/10.5599/admet.757	NOUN
admet-929	550	4	.	.	PUNCT
admet-929	551	1	https://doi.org/10.2174/0929867013372643	https://doi.org/10.2174/0929867013372643	PROPN
admet-929	551	2	https://doi.org/10.2174/0929867013372643	https://doi.org/10.2174/0929867013372643	PROPN
admet-929	552	1	https://doi.org/10.1002/jps.10494	https://doi.org/10.1002/jps.10494	VERB
admet-929	552	2	https://doi.org/10.1002/jps.10494	https://doi.org/10.1002/jps.10494	PROPN
admet-929	552	3	https://doi.org/10.1093/jac/dkg319	https://doi.org/10.1093/jac/dkg319	PROPN
admet-929	552	4	https://doi.org/10.1093/jac/dkg319	https://doi.org/10.1093/jac/dkg319	PROPN
admet-929	552	5	https://doi.org/10.1016/j.jpba.2011.11.033	https://doi.org/10.1016/j.jpba.2011.11.033	NUM
admet-929	552	6	https://doi.org/10.1016/j.jpba.2011.11.033	https://doi.org/10.1016/j.jpba.2011.11.033	NOUN
admet-929	552	7	https://doi.org/10.1111/bph.12967	https://doi.org/10.1111/bph.12967	PROPN
admet-929	552	8	https://doi.org/10.1016/j.ejps.2007.04.003	https://doi.org/10.1016/j.ejps.2007.04.003	PROPN
admet-929	552	9	https://doi.org/10.1002/bmc.1130090504	https://doi.org/10.1002/bmc.1130090504	PROPN
admet-929	552	10	https://doi.org/10.1081/dmr-100104402	https://doi.org/10.1081/dmr-100104402	ADP
admet-929	552	11	https://doi.org/10.1021/jm050957i	https://doi.org/10.1021/jm050957i	PROPN
admet-929	552	12	https://doi.org/10.1021/jm050957i	https://doi.org/10.1021/jm050957i	PROPN
admet-929	552	13	https://doi.org/10.1016/j.bbalip.2012.08.013	https://doi.org/10.1016/j.bbalip.2012.08.013	PROPN
admet-929	552	14	https://doi.org/10.1053/hupa.2003.36	https://doi.org/10.1053/hupa.2003.36	PROPN
admet-929	552	15	https://doi.org/10.1078/0940-2993-00338	https://doi.org/10.1078/0940-2993-00338	PROPN
admet-929	552	16	https://doi.org/10.1021/jm050957i	https://doi.org/10.1021/jm050957i	PROPN
admet-929	552	17	https://doi.org/10.1021/jm050957i	https://doi.org/10.1021/jm050957i	ADV
admet-929	552	18	https://doi.org/10.5599/admet.757	https://doi.org/10.5599/admet.757	DET
admet-929	552	19	admet	admet	X
admet-929	552	20	&	&	CCONJ
admet-929	552	21	dmpk	dmpk	PROPN
admet-929	552	22	9(2	9(2	NUM
admet-929	552	23	)	)	PUNCT
admet-929	552	24	(	(	PUNCT
admet-929	552	25	2021	2021	NUM
admet-929	552	26	)	)	PUNCT
admet-929	552	27	151	151	NUM
admet-929	552	28	-	-	SYM
admet-929	552	29	165	165	NUM
admet-929	552	30	biomimetic	biomimetic	ADJ
admet-929	552	31	properties	property	NOUN
admet-929	552	32	of	of	ADP
admet-929	552	33	chlorquine	chlorquine	NOUN
admet-929	552	34	enantiomers	enantiomer	NOUN
admet-929	552	35	doi	doi	NOUN
admet-929	552	36	:	:	PUNCT
admet-929	552	37	https://doi.org/10.5599/admet.929	https://doi.org/10.5599/admet.929	NOUN
admet-929	552	38	165	165	NUM
admet-929	553	1	[	[	X
admet-929	553	2	45	45	NUM
admet-929	553	3	]	]	PUNCT
admet-929	553	4	k.	k.	PROPN
admet-929	553	5	valko	valko	PROPN
admet-929	553	6	,	,	PUNCT
admet-929	553	7	e.	e.	PROPN
admet-929	553	8	chiarparin	chiarparin	PROPN
admet-929	553	9	,	,	PUNCT
admet-929	553	10	s.	s.	PROPN
admet-929	553	11	nunhuck	nunhuck	PROPN
admet-929	553	12	,	,	PUNCT
admet-929	553	13	d.	d.	PROPN
admet-929	553	14	montanari	montanari	PROPN
admet-929	553	15	.	.	PUNCT
admet-929	554	1	in	in	ADP
admet-929	554	2	vitro	vitro	X
admet-929	554	3	measurement	measurement	NOUN
admet-929	554	4	of	of	ADP
admet-929	554	5	drug	drug	NOUN
admet-929	554	6	efficiency	efficiency	NOUN
admet-929	554	7	index	index	NOUN
admet-929	554	8	to	to	PART
admet-929	554	9	aid	aid	VERB
admet-929	554	10	early	early	ADJ
admet-929	554	11	lead	lead	ADJ
admet-929	554	12	optimization	optimization	NOUN
admet-929	554	13	.	.	PUNCT
admet-929	555	1	j.	j.	PROPN
admet-929	555	2	pharm	pharm	PROPN
admet-929	555	3	.	.	PUNCT
admet-929	556	1	sci	sci	PROPN
admet-929	556	2	.	.	PROPN
admet-929	557	1	101	101	NUM
admet-929	557	2	(	(	PUNCT
admet-929	557	3	2012	2012	NUM
admet-929	557	4	)	)	PUNCT
admet-929	557	5	.	.	PUNCT
admet-929	558	1	doi	doi	NOUN
admet-929	558	2	:	:	PUNCT
admet-929	558	3	https://doi.org/10.1002/jps.23305	https://doi.org/10.1002/jps.23305	NOUN
admet-929	558	4	.	.	PUNCT
admet-929	559	1	[	[	X
admet-929	559	2	46	46	NUM
admet-929	559	3	]	]	X
admet-929	559	4	l.j	l.j	PROPN
admet-929	559	5	.	.	PROPN
admet-929	559	6	gordon	gordon	PROPN
admet-929	559	7	,	,	PUNCT
admet-929	559	8	m.	m.	NOUN
admet-929	559	9	allen	allen	PROPN
admet-929	559	10	,	,	PUNCT
admet-929	559	11	p.e.r	p.e.r	PROPN
admet-929	559	12	.	.	PUNCT
admet-929	559	13	artursson	artursson	PROPN
admet-929	559	14	,	,	PUNCT
admet-929	559	15	m.m	m.m	PROPN
admet-929	559	16	.	.	PROPN
admet-929	559	17	hann	hann	PROPN
admet-929	559	18	,	,	PUNCT
admet-929	559	19	b.j	b.j	PROPN
admet-929	559	20	.	.	PROPN
admet-929	559	21	leavens	leaven	VERB
admet-929	559	22	,	,	PUNCT
admet-929	559	23	a.	a.	NOUN
admet-929	559	24	mateus	mateus	PROPN
admet-929	559	25	,	,	PUNCT
admet-929	559	26	s.i.m.o.n	s.i.m.o.n	X
admet-929	559	27	.	.	PUNCT
admet-929	560	1	readshaw	readshaw	PROPN
admet-929	560	2	,	,	PUNCT
admet-929	560	3	k.	k.	PROPN
admet-929	560	4	valko	valko	PROPN
admet-929	560	5	,	,	PUNCT
admet-929	560	6	g.j	g.j	PROPN
admet-929	560	7	.	.	PROPN
admet-929	560	8	wayne	wayne	PROPN
admet-929	560	9	,	,	PUNCT
admet-929	560	10	a.n.d.y	a.n.d.y	PROPN
admet-929	560	11	.	.	PUNCT
admet-929	560	12	west	west	PROPN
admet-929	560	13	.	.	PUNCT
admet-929	561	1	direct	direct	ADJ
admet-929	561	2	measurement	measurement	NOUN
admet-929	561	3	of	of	ADP
admet-929	561	4	intracellular	intracellular	ADJ
admet-929	561	5	compound	compound	NOUN
admet-929	561	6	concentration	concentration	NOUN
admet-929	561	7	by	by	ADP
admet-929	561	8	rapidfire	rapidfire	NOUN
admet-929	561	9	mass	mass	PROPN
admet-929	561	10	spectrometry	spectrometry	NOUN
admet-929	561	11	offers	offer	VERB
admet-929	561	12	insights	insight	NOUN
admet-929	561	13	into	into	ADP
admet-929	561	14	cell	cell	NOUN
admet-929	561	15	permeability	permeability	NOUN
admet-929	561	16	.	.	PUNCT
admet-929	562	1	j.	j.	PROPN
admet-929	562	2	biomol	biomol	PROPN
admet-929	562	3	.	.	PUNCT
admet-929	563	1	screen	screen	NOUN
admet-929	563	2	.	.	PUNCT
admet-929	564	1	21	21	NUM
admet-929	564	2	(	(	PUNCT
admet-929	564	3	2016	2016	NUM
admet-929	564	4	)	)	PUNCT
admet-929	564	5	.	.	PUNCT
admet-929	565	1	doi	doi	NOUN
admet-929	565	2	:	:	PUNCT
admet-929	565	3	https://doi.org/10.1177/1087057115604141	https://doi.org/10.1177/1087057115604141	X
admet-929	565	4	.	.	PUNCT
admet-929	566	1	[	[	X
admet-929	566	2	47	47	NUM
admet-929	566	3	]	]	PUNCT
admet-929	566	4	s.	s.	PROPN
admet-929	566	5	krishna	krishna	PROPN
admet-929	566	6	,	,	PUNCT
admet-929	566	7	n.j	n.j	PROPN
admet-929	566	8	.	.	PROPN
admet-929	566	9	white	white	PROPN
admet-929	566	10	.	.	PUNCT
admet-929	567	1	pharmacokinetics	pharmacokinetic	NOUN
admet-929	567	2	of	of	ADP
admet-929	567	3	quinine	quinine	NOUN
admet-929	567	4	,	,	PUNCT
admet-929	567	5	chloroquine	chloroquine	NOUN
admet-929	567	6	and	and	CCONJ
admet-929	567	7	amodiaquine	amodiaquine	PROPN
admet-929	567	8	.	.	PUNCT
admet-929	568	1	clinical	clinical	ADJ
admet-929	568	2	implications	implication	NOUN
admet-929	568	3	.	.	PUNCT
admet-929	569	1	clin	clin	PROPN
admet-929	569	2	.	.	PUNCT
admet-929	569	3	pharmacokinet	pharmacokinet	PROPN
admet-929	569	4	.	.	PUNCT
admet-929	570	1	30	30	NUM
admet-929	570	2	(	(	PUNCT
admet-929	570	3	1996	1996	NUM
admet-929	570	4	)	)	PUNCT
admet-929	571	1	263–299	263–299	NUM
admet-929	571	2	.	.	PUNCT
admet-929	572	1	doi	doi	NOUN
admet-929	572	2	:	:	PUNCT
admet-929	572	3	https://doi.org/10.2165/00003088199630040-00002	https://doi.org/10.2165/00003088199630040-00002	NOUN
admet-929	572	4	.	.	PUNCT
admet-929	573	1	[	[	X
admet-929	573	2	48	48	NUM
admet-929	573	3	]	]	SYM
admet-929	573	4	h.s	h.s	PROPN
admet-929	573	5	.	.	PROPN
admet-929	573	6	lim	lim	PROPN
admet-929	573	7	,	,	PUNCT
admet-929	573	8	j.s	j.s	PROPN
admet-929	573	9	.	.	PUNCT
admet-929	574	1	i	i	PRON
admet-929	574	2	m	m	PROPN
admet-929	574	3	,	,	PUNCT
admet-929	575	1	j.y	j.y	PROPN
admet-929	575	2	.	.	PROPN
admet-929	575	3	cho	cho	PROPN
admet-929	575	4	,	,	PUNCT
admet-929	575	5	k.s	k.s	PROPN
admet-929	575	6	.	.	PROPN
admet-929	575	7	bae	bae	PROPN
admet-929	575	8	,	,	PUNCT
admet-929	575	9	t.a	t.a	PROPN
admet-929	575	10	.	.	PROPN
admet-929	575	11	klein	klein	PROPN
admet-929	575	12	,	,	PUNCT
admet-929	575	13	j.s	j.s	PROPN
admet-929	575	14	.	.	PROPN
admet-929	575	15	yeom	yeom	PROPN
admet-929	575	16	,	,	PUNCT
admet-929	575	17	t.s	t.s	PROPN
admet-929	575	18	.	.	PROPN
admet-929	575	19	kim	kim	PROPN
admet-929	575	20	,	,	PUNCT
admet-929	575	21	j.s	j.s	PROPN
admet-929	575	22	.	.	PROPN
admet-929	575	23	choi	choi	PROPN
admet-929	575	24	,	,	PUNCT
admet-929	575	25	i.j	i.j	PROPN
admet-929	575	26	.	.	PROPN
admet-929	575	27	jang	jang	PROPN
admet-929	575	28	,	,	PUNCT
admet-929	575	29	j.w	j.w	PROPN
admet-929	575	30	.	.	PROPN
admet-929	575	31	park	park	PROPN
admet-929	575	32	.	.	PUNCT
admet-929	576	1	pharmacokinetics	pharmacokinetic	NOUN
admet-929	576	2	of	of	ADP
admet-929	576	3	hydroxychloroquine	hydroxychloroquine	NOUN
admet-929	576	4	and	and	CCONJ
admet-929	576	5	its	its	PRON
admet-929	576	6	clinical	clinical	ADJ
admet-929	576	7	implications	implication	NOUN
admet-929	576	8	in	in	ADP
admet-929	576	9	chemoprophylaxis	chemoprophylaxis	NOUN
admet-929	576	10	against	against	ADP
admet-929	576	11	malaria	malaria	NOUN
admet-929	576	12	caused	cause	VERB
admet-929	576	13	by	by	ADP
admet-929	576	14	plasmodium	plasmodium	NOUN
admet-929	576	15	vivax	vivax	NOUN
admet-929	576	16	.	.	PUNCT
admet-929	577	1	antimicrob	antimicrob	PROPN
admet-929	577	2	.	.	PUNCT
admet-929	578	1	agents	agent	NOUN
admet-929	578	2	chemother	chemother	PROPN
admet-929	578	3	.	.	PUNCT
admet-929	579	1	53	53	NUM
admet-929	579	2	(	(	PUNCT
admet-929	579	3	2009	2009	NUM
admet-929	579	4	)	)	PUNCT
admet-929	580	1	1468–1475	1468–1475	NUM
admet-929	580	2	.	.	PUNCT
admet-929	581	1	doi	doi	NOUN
admet-929	581	2	:	:	PUNCT
admet-929	581	3	https://doi.org/10.1128/aac.00339-08	https://doi.org/10.1128/aac.00339-08	NOUN
admet-929	581	4	.	.	PUNCT
admet-929	582	1	[	[	X
admet-929	582	2	49	49	NUM
admet-929	582	3	]	]	PUNCT
admet-929	582	4	l.	l.	PROPN
admet-929	582	5	gustafsson	gustafsson	PROPN
admet-929	582	6	,	,	PUNCT
admet-929	582	7	o.	o.	PROPN
admet-929	582	8	walker	walker	PROPN
admet-929	582	9	,	,	PUNCT
admet-929	582	10	g.	g.	PROPN
admet-929	582	11	alvan	alvan	PROPN
admet-929	582	12	,	,	PUNCT
admet-929	582	13	b.	b.	PROPN
admet-929	582	14	beermann	beermann	PROPN
admet-929	582	15	,	,	PUNCT
admet-929	582	16	f.	f.	PROPN
admet-929	582	17	estevez	estevez	PROPN
admet-929	582	18	,	,	PUNCT
admet-929	582	19	l.	l.	PROPN
admet-929	582	20	gleisner	gleisner	PROPN
admet-929	582	21	,	,	PUNCT
admet-929	582	22	b.	b.	PROPN
admet-929	582	23	lindstrom	lindstrom	PROPN
admet-929	582	24	,	,	PUNCT
admet-929	582	25	f.	f.	PROPN
admet-929	582	26	sjoqvist	sjoqvist	PROPN
admet-929	582	27	.	.	PUNCT
admet-929	583	1	disposition	disposition	NOUN
admet-929	583	2	of	of	ADP
admet-929	583	3	chloroquine	chloroquine	NOUN
admet-929	583	4	in	in	ADP
admet-929	583	5	man	man	NOUN
admet-929	583	6	after	after	ADP
admet-929	583	7	single	single	ADJ
admet-929	583	8	intravenous	intravenous	ADJ
admet-929	583	9	and	and	CCONJ
admet-929	583	10	oral	oral	ADJ
admet-929	583	11	doses	dose	NOUN
admet-929	583	12	.	.	PUNCT
admet-929	584	1	br	br	PROPN
admet-929	584	2	.	.	PUNCT
admet-929	585	1	j.	j.	PROPN
admet-929	585	2	clin	clin	PROPN
admet-929	585	3	.	.	PUNCT
admet-929	586	1	pharmacol	pharmacol	PROPN
admet-929	586	2	.	.	PROPN
admet-929	587	1	15	15	NUM
admet-929	587	2	(	(	PUNCT
admet-929	587	3	1983	1983	NUM
admet-929	587	4	)	)	PUNCT
admet-929	588	1	471–479	471–479	NUM
admet-929	588	2	.	.	PUNCT
admet-929	589	1	doi	doi	NOUN
admet-929	589	2	:	:	PUNCT
admet-929	590	1	https://doi.org/10.1111/j.1365-2125.1983.tb01532.x	https://doi.org/10.1111/j.1365-2125.1983.tb01532.x	PROPN
admet-929	590	2	.	.	PUNCT
admet-929	591	1	[	[	X
admet-929	591	2	50	50	NUM
admet-929	591	3	]	]	PUNCT
admet-929	591	4	s.	s.	PROPN
admet-929	591	5	tett	tett	PROPN
admet-929	591	6	,	,	PUNCT
admet-929	591	7	d.	d.	PROPN
admet-929	591	8	cutler	cutler	PROPN
admet-929	591	9	,	,	PUNCT
admet-929	591	10	r.	r.	PROPN
admet-929	591	11	day	day	PROPN
admet-929	591	12	,	,	PUNCT
admet-929	591	13	k.	k.	PROPN
admet-929	591	14	brown	brown	PROPN
admet-929	591	15	.	.	PUNCT
admet-929	592	1	a	a	DET
admet-929	592	2	dose‐ranging	dose‐range	VERB
admet-929	592	3	study	study	NOUN
admet-929	592	4	of	of	ADP
admet-929	592	5	the	the	DET
admet-929	592	6	pharmacokinetics	pharmacokinetic	NOUN
admet-929	592	7	of	of	ADP
admet-929	592	8	hydroxychloroquine	hydroxychloroquine	NOUN
admet-929	592	9	following	follow	VERB
admet-929	592	10	intravenous	intravenous	ADJ
admet-929	592	11	administration	administration	NOUN
admet-929	592	12	to	to	ADP
admet-929	592	13	healthy	healthy	ADJ
admet-929	592	14	volunteers	volunteer	NOUN
admet-929	592	15	.	.	PUNCT
admet-929	593	1	br	br	X
admet-929	593	2	.	.	PUNCT
admet-929	594	1	j.	j.	PROPN
admet-929	594	2	clin	clin	PROPN
admet-929	594	3	.	.	PUNCT
admet-929	595	1	pharmacol	pharmacol	PROPN
admet-929	595	2	.	.	PROPN
admet-929	596	1	26	26	NUM
admet-929	596	2	(	(	PUNCT
admet-929	596	3	1988	1988	NUM
admet-929	596	4	)	)	PUNCT
admet-929	597	1	303–313	303–313	NUM
admet-929	597	2	.	.	PUNCT
admet-929	598	1	doi	doi	NOUN
admet-929	598	2	:	:	PUNCT
admet-929	598	3	https://doi.org/10.1111/j.1365-2125.1988.tb05281.x	https://doi.org/10.1111/j.1365-2125.1988.tb05281.x	PROPN
admet-929	598	4	.	.	PUNCT
admet-929	599	1	[	[	X
admet-929	599	2	51	51	NUM
admet-929	599	3	]	]	X
admet-929	599	4	d.e	d.e	PROPN
admet-929	599	5	.	.	PROPN
admet-929	599	6	furst	furst	PROPN
admet-929	599	7	.	.	PUNCT
admet-929	600	1	pharmacokinetics	pharmacokinetic	NOUN
admet-929	600	2	of	of	ADP
admet-929	600	3	hydroxychloroquine	hydroxychloroquine	NOUN
admet-929	600	4	and	and	CCONJ
admet-929	600	5	chloroquine	chloroquine	NOUN
admet-929	600	6	during	during	ADP
admet-929	600	7	treatment	treatment	NOUN
admet-929	600	8	of	of	ADP
admet-929	600	9	rheumatic	rheumatic	ADJ
admet-929	600	10	diseases	disease	NOUN
admet-929	600	11	.	.	PUNCT
admet-929	601	1	lupus	lupus	NOUN
admet-929	601	2	5	5	NUM
admet-929	601	3	(	(	PUNCT
admet-929	601	4	1996	1996	NUM
admet-929	601	5	)	)	PUNCT
admet-929	601	6	11–15	11–15	NUM
admet-929	601	7	.	.	PUNCT
admet-929	601	8	doi	doi	NOUN
admet-929	601	9	:	:	PUNCT
admet-929	601	10	https://doi.org/10.1177/0961203396005001041	https://doi.org/10.1177/0961203396005001041	NOUN
admet-929	601	11	.	.	PUNCT
admet-929	602	1	[	[	X
admet-929	602	2	52	52	NUM
admet-929	602	3	]	]	X
admet-929	602	4	a.j	a.j	PROPN
admet-929	602	5	.	.	PROPN
admet-929	602	6	mclachlan	mclachlan	PROPN
admet-929	602	7	,	,	PUNCT
admet-929	602	8	s.e	s.e	PROPN
admet-929	602	9	.	.	PROPN
admet-929	602	10	tett	tett	PROPN
admet-929	602	11	,	,	PUNCT
admet-929	602	12	d.j	d.j	PROPN
admet-929	602	13	.	.	PROPN
admet-929	602	14	cutler	cutler	PROPN
admet-929	602	15	,	,	PUNCT
admet-929	602	16	r.o	r.o	PROPN
admet-929	602	17	.	.	PROPN
admet-929	602	18	day	day	PROPN
admet-929	602	19	.	.	PUNCT
admet-929	603	1	disposition	disposition	NOUN
admet-929	603	2	and	and	CCONJ
admet-929	603	3	absorption	absorption	NOUN
admet-929	603	4	of	of	ADP
admet-929	603	5	hydroxychloroquine	hydroxychloroquine	ADJ
admet-929	603	6	enantiomers	enantiomer	NOUN
admet-929	603	7	following	follow	VERB
admet-929	603	8	a	a	DET
admet-929	603	9	single	single	ADJ
admet-929	603	10	dose	dose	NOUN
admet-929	603	11	of	of	ADP
admet-929	603	12	the	the	DET
admet-929	603	13	racemate	racemate	NOUN
admet-929	603	14	.	.	PUNCT
admet-929	604	1	chirality	chirality	NOUN
admet-929	604	2	6	6	NUM
admet-929	604	3	(	(	PUNCT
admet-929	604	4	1994	1994	NUM
admet-929	604	5	)	)	PUNCT
admet-929	604	6	360–364	360–364	NUM
admet-929	604	7	.	.	PUNCT
admet-929	605	1	doi	doi	NOUN
admet-929	605	2	:	:	PUNCT
admet-929	605	3	https://doi.org/10.1002/chir.530060421	https://doi.org/10.1002/chir.530060421	NOUN
admet-929	605	4	.	.	PUNCT
admet-929	606	1	[	[	X
admet-929	606	2	53	53	NUM
admet-929	606	3	]	]	X
admet-929	606	4	i.w	i.w	PROPN
admet-929	606	5	.	.	PROPN
admet-929	606	6	wainer	wainer	PROPN
admet-929	606	7	,	,	PUNCT
admet-929	606	8	j.c	j.c	PROPN
admet-929	606	9	.	.	PROPN
admet-929	606	10	chen	chen	PROPN
admet-929	606	11	,	,	PUNCT
admet-929	606	12	h.	h.	PROPN
admet-929	606	13	parenteau	parenteau	PROPN
admet-929	606	14	,	,	PUNCT
admet-929	606	15	s.	s.	PROPN
admet-929	606	16	abdullah	abdullah	PROPN
admet-929	606	17	,	,	PUNCT
admet-929	606	18	j.	j.	PROPN
admet-929	606	19	ducharme	ducharme	PROPN
admet-929	606	20	,	,	PUNCT
admet-929	606	21	h.	h.	PROPN
admet-929	606	22	fieger	fieger	PROPN
admet-929	606	23	,	,	PUNCT
admet-929	606	24	j.	j.	PROPN
admet-929	606	25	iredale	iredale	PROPN
admet-929	606	26	.	.	PUNCT
admet-929	607	1	distribution	distribution	NOUN
admet-929	607	2	of	of	ADP
admet-929	607	3	the	the	DET
admet-929	607	4	enantiomers	enantiomer	NOUN
admet-929	607	5	of	of	ADP
admet-929	607	6	hydroxychloroquine	hydroxychloroquine	NOUN
admet-929	607	7	and	and	CCONJ
admet-929	607	8	its	its	PRON
admet-929	607	9	metabolites	metabolite	NOUN
admet-929	607	10	in	in	ADP
admet-929	607	11	ocular	ocular	ADJ
admet-929	607	12	tissues	tissue	NOUN
admet-929	607	13	of	of	ADP
admet-929	607	14	the	the	DET
admet-929	607	15	rabbit	rabbit	NOUN
admet-929	607	16	after	after	ADP
admet-929	607	17	oral	oral	ADJ
admet-929	607	18	administration	administration	NOUN
admet-929	607	19	of	of	ADP
admet-929	607	20	racemic‐hydroxychloroquine	racemic‐hydroxychloroquine	NOUN
admet-929	607	21	.	.	PUNCT
admet-929	608	1	chirality	chirality	NOUN
admet-929	608	2	6	6	NUM
admet-929	608	3	(	(	PUNCT
admet-929	608	4	1994	1994	NUM
admet-929	608	5	)	)	PUNCT
admet-929	609	1	347–354	347–354	NUM
admet-929	609	2	.	.	PUNCT
admet-929	610	1	doi	doi	NOUN
admet-929	610	2	:	:	PUNCT
admet-929	610	3	https://doi.org/10.1002/chir.530060419	https://doi.org/10.1002/chir.530060419	X
admet-929	610	4	.	.	PUNCT
admet-929	611	1	[	[	X
admet-929	611	2	54	54	NUM
admet-929	611	3	]	]	X
admet-929	611	4	p.	p.	NOUN
admet-929	611	5	augustijns	augustijns	NOUN
admet-929	611	6	,	,	PUNCT
admet-929	611	7	n.	n.	PROPN
admet-929	611	8	verbeke	verbeke	PROPN
admet-929	611	9	.	.	PUNCT
admet-929	612	1	stereoselective	stereoselective	ADJ
admet-929	612	2	pharmacokinetic	pharmacokinetic	ADJ
admet-929	612	3	properties	property	NOUN
admet-929	612	4	of	of	ADP
admet-929	612	5	chloroquine	chloroquine	NOUN
admet-929	612	6	and	and	CCONJ
admet-929	612	7	de	de	NOUN
admet-929	612	8	-	-	NOUN
admet-929	612	9	ethylchloroquine	ethylchloroquine	NOUN
admet-929	612	10	in	in	ADP
admet-929	612	11	humans	human	NOUN
admet-929	612	12	.	.	PUNCT
admet-929	613	1	clin	clin	PROPN
admet-929	613	2	.	.	PUNCT
admet-929	613	3	pharmacokinet	pharmacokinet	PROPN
admet-929	613	4	.	.	PUNCT
admet-929	614	1	24	24	NUM
admet-929	614	2	(	(	PUNCT
admet-929	614	3	1993	1993	NUM
admet-929	614	4	)	)	PUNCT
admet-929	615	1	259–269	259–269	NUM
admet-929	615	2	.	.	PUNCT
admet-929	616	1	doi	doi	NOUN
admet-929	616	2	:	:	PUNCT
admet-929	616	3	https://doi.org/10.2165/00003088-199324030-00007	https://doi.org/10.2165/00003088-199324030-00007	ADJ
admet-929	616	4	.	.	PUNCT
admet-929	617	1	©	©	NOUN
admet-929	617	2	2021	2021	NUM
admet-929	617	3	by	by	ADP
admet-929	617	4	the	the	DET
admet-929	617	5	authors	author	NOUN
admet-929	617	6	;	;	PUNCT
admet-929	617	7	licensee	licensee	PROPN
admet-929	617	8	iapc	iapc	PROPN
admet-929	617	9	,	,	PUNCT
admet-929	617	10	zagreb	zagreb	PROPN
admet-929	617	11	,	,	PUNCT
admet-929	617	12	croatia	croatia	PROPN
admet-929	617	13	.	.	PUNCT
admet-929	618	1	this	this	DET
admet-929	618	2	article	article	NOUN
admet-929	618	3	is	be	AUX
admet-929	618	4	an	an	DET
admet-929	618	5	open	open	ADJ
admet-929	618	6	-	-	PUNCT
admet-929	618	7	access	access	NOUN
admet-929	618	8	article	article	NOUN
admet-929	618	9	distributed	distribute	VERB
admet-929	618	10	under	under	ADP
admet-929	618	11	the	the	DET
admet-929	618	12	terms	term	NOUN
admet-929	618	13	and	and	CCONJ
admet-929	618	14	conditions	condition	NOUN
admet-929	618	15	of	of	ADP
admet-929	618	16	the	the	DET
admet-929	618	17	creative	creative	ADJ
admet-929	618	18	commons	common	NOUN
admet-929	618	19	attribution	attribution	NOUN
admet-929	618	20	license	license	NOUN
admet-929	618	21	(	(	PUNCT
admet-929	618	22	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-929	618	23	)	)	PUNCT
admet-929	618	24	https://doi.org/10.5599/admet.929	https://doi.org/10.5599/admet.929	NOUN
admet-929	618	25	https://doi.org/10.1002/jps.23305	https://doi.org/10.1002/jps.23305	PROPN
admet-929	618	26	https://doi.org/10.1177/1087057115604141	https://doi.org/10.1177/1087057115604141	VERB
admet-929	618	27	https://doi.org/10.2165/00003088-199630040-00002	https://doi.org/10.2165/00003088-199630040-00002	ADV
admet-929	618	28	https://doi.org/10.2165/00003088-199630040-00002	https://doi.org/10.2165/00003088-199630040-00002	ADJ
admet-929	618	29	https://doi.org/10.1128/aac.00339-08	https://doi.org/10.1128/aac.00339-08	PROPN
admet-929	618	30	https://doi.org/10.1111/j.1365-2125.1983.tb01532.x	https://doi.org/10.1111/j.1365-2125.1983.tb01532.x	PROPN
admet-929	619	1	https://doi.org/10.1111/j.1365-2125.1988.tb05281.x	https://doi.org/10.1111/j.1365-2125.1988.tb05281.x	ADP
admet-929	619	2	https://doi.org/10.1177/0961203396005001041	https://doi.org/10.1177/0961203396005001041	NOUN
admet-929	620	1	https://doi.org/10.1002/chir.530060421	https://doi.org/10.1002/chir.530060421	NOUN
admet-929	620	2	https://doi.org/10.1002/chir.530060421	https://doi.org/10.1002/chir.530060421	NOUN
admet-929	620	3	https://doi.org/10.1002/chir.530060419	https://doi.org/10.1002/chir.530060419	VERB
admet-929	620	4	https://doi.org/10.1002/chir.530060419	https://doi.org/10.1002/chir.530060419	PRON
admet-929	620	5	https://doi.org/10.2165/00003088-199324030-00007	https://doi.org/10.2165/00003088-199324030-00007	ADJ
admet-929	620	6	https://doi.org/10.2165/00003088-199324030-00007	https://doi.org/10.2165/00003088-199324030-00007	ADJ
admet-929	620	7	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN