id	sid	tid	token	lemma	pos
admet-995	1	1	prediction	prediction	NOUN
admet-995	1	2	of	of	ADP
admet-995	1	3	herg	herg	PROPN
admet-995	1	4	inhibition	inhibition	NOUN
admet-995	1	5	of	of	ADP
admet-995	1	6	drug	drug	NOUN
admet-995	1	7	discovery	discovery	NOUN
admet-995	1	8	compounds	compound	NOUN
admet-995	1	9	using	use	VERB
admet-995	1	10	biomimetic	biomimetic	ADJ
admet-995	1	11	hplc	hplc	NOUN
admet-995	1	12	measurements	measurement	NOUN
admet-995	1	13	doi	doi	PROPN
admet-995	1	14	:	:	PUNCT
admet-995	1	15	http://dx.doi.org/10.5599/admet.995	http://dx.doi.org/10.5599/admet.995	ADJ
admet-995	1	16	191	191	NUM
admet-995	1	17	admet	admet	X
admet-995	1	18	&	&	CCONJ
admet-995	1	19	dmpk	dmpk	PROPN
admet-995	1	20	9(3	9(3	NUM
admet-995	1	21	)	)	PUNCT
admet-995	1	22	(	(	PUNCT
admet-995	1	23	2021	2021	NUM
admet-995	1	24	)	)	PUNCT
admet-995	1	25	191	191	NUM
admet-995	1	26	-	-	SYM
admet-995	1	27	207	207	NUM
admet-995	1	28	;	;	PUNCT
admet-995	1	29	doi	doi	NOUN
admet-995	1	30	:	:	PUNCT
admet-995	1	31	https://doi.org/10.5599/admet.995	https://doi.org/10.5599/admet.995	NOUN
admet-995	1	32	open	open	ADJ
admet-995	1	33	access	access	NOUN
admet-995	1	34	:	:	PUNCT
admet-995	1	35	issn	issn	PROPN
admet-995	1	36	:	:	PUNCT
admet-995	1	37	1848	1848	NUM
admet-995	1	38	-	-	SYM
admet-995	1	39	7718	7718	NUM
admet-995	1	40	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-995	1	41	original	original	ADJ
admet-995	1	42	scientific	scientific	ADJ
admet-995	1	43	paper	paper	NOUN
admet-995	1	44	prediction	prediction	NOUN
admet-995	1	45	of	of	ADP
admet-995	1	46	herg	herg	PROPN
admet-995	1	47	inhibition	inhibition	NOUN
admet-995	1	48	of	of	ADP
admet-995	1	49	drug	drug	NOUN
admet-995	1	50	discovery	discovery	NOUN
admet-995	1	51	compounds	compound	NOUN
admet-995	1	52	using	use	VERB
admet-995	1	53	biomimetic	biomimetic	ADJ
admet-995	1	54	hplc	hplc	NOUN
admet-995	1	55	measurements	measurement	NOUN
admet-995	1	56	chrysanthos	chrysanthos	PROPN
admet-995	1	57	stergiopoulos1	stergiopoulos1	PROPN
admet-995	1	58	*	*	PROPN
admet-995	1	59	,	,	PUNCT
admet-995	1	60	fotios	fotio	NOUN
admet-995	1	61	tsopelas1	tsopelas1	NOUN
admet-995	1	62	and	and	CCONJ
admet-995	1	63	klara	klara	PROPN
admet-995	1	64	valko2	valko2	PROPN
admet-995	1	65	1	1	NUM
admet-995	1	66	laboratory	laboratory	NOUN
admet-995	1	67	of	of	ADP
admet-995	1	68	inorganic	inorganic	ADJ
admet-995	1	69	and	and	CCONJ
admet-995	1	70	analytical	analytical	ADJ
admet-995	1	71	chemistry	chemistry	NOUN
admet-995	1	72	,	,	PUNCT
admet-995	1	73	school	school	NOUN
admet-995	1	74	of	of	ADP
admet-995	1	75	chemical	chemical	PROPN
admet-995	1	76	engineering	engineering	NOUN
admet-995	1	77	,	,	PUNCT
admet-995	1	78	national	national	PROPN
admet-995	1	79	technical	technical	PROPN
admet-995	1	80	university	university	PROPN
admet-995	1	81	of	of	ADP
admet-995	1	82	athens	athens	PROPN
admet-995	1	83	2	2	NUM
admet-995	1	84	bio	bio	ADJ
admet-995	1	85	-	-	ADJ
admet-995	1	86	mimetic	mimetic	ADJ
admet-995	1	87	chromatography	chromatography	PROPN
admet-995	1	88	ltd	ltd	PROPN
admet-995	1	89	.	.	PROPN
admet-995	1	90	stevenage	stevenage	PROPN
admet-995	1	91	,	,	PUNCT
admet-995	1	92	herts	hert	NOUN
admet-995	1	93	,	,	PUNCT
admet-995	1	94	united	united	ADJ
admet-995	1	95	kingdom	kingdom	PROPN
admet-995	1	96	*	*	PUNCT
admet-995	1	97	corresponding	correspond	VERB
admet-995	1	98	author	author	NOUN
admet-995	1	99	:	:	PUNCT
admet-995	1	100	chrysanthos	chrysanthos	PROPN
admet-995	1	101	stergiopoulos	stergiopoulos	PROPN
admet-995	1	102	;	;	PUNCT
admet-995	1	103	e	e	X
admet-995	1	104	-	-	NOUN
admet-995	1	105	mail	mail	NOUN
admet-995	1	106	:	:	PUNCT
admet-995	1	107	chrisxp3@hotmail.com	chrisxp3@hotmail.com	X
admet-995	1	108	;	;	PUNCT
admet-995	1	109	tel	tel	PROPN
admet-995	1	110	.	.	PUNCT
admet-995	1	111	:	:	PUNCT
admet-995	1	112	+302107724022	+302107724022	PROPN
admet-995	1	113	received	receive	VERB
admet-995	1	114	:	:	PUNCT
admet-995	1	115	april	april	PROPN
admet-995	1	116	06	06	NUM
admet-995	1	117	,	,	PUNCT
admet-995	1	118	2021	2021	NUM
admet-995	1	119	;	;	PUNCT
admet-995	1	120	revised	revise	VERB
admet-995	1	121	:	:	PUNCT
admet-995	1	122	may	may	AUX
admet-995	1	123	20	20	NUM
admet-995	1	124	,	,	PUNCT
admet-995	1	125	2021	2021	NUM
admet-995	1	126	;	;	PUNCT
admet-995	1	127	available	available	ADJ
admet-995	1	128	online	online	PROPN
admet-995	1	129	:	:	PUNCT
admet-995	1	130	june	june	PROPN
admet-995	1	131	06	06	NUM
admet-995	1	132	,	,	PUNCT
admet-995	1	133	2021	2021	NUM
admet-995	1	134	abstract	abstract	NOUN
admet-995	1	135	the	the	DET
admet-995	1	136	major	major	ADJ
admet-995	1	137	causes	cause	NOUN
admet-995	1	138	of	of	ADP
admet-995	1	139	failure	failure	NOUN
admet-995	1	140	of	of	ADP
admet-995	1	141	drug	drug	NOUN
admet-995	1	142	discovery	discovery	NOUN
admet-995	1	143	compounds	compound	NOUN
admet-995	1	144	in	in	ADP
admet-995	1	145	clinics	clinic	NOUN
admet-995	1	146	are	be	AUX
admet-995	1	147	the	the	DET
admet-995	1	148	lack	lack	NOUN
admet-995	1	149	of	of	ADP
admet-995	1	150	efficacy	efficacy	NOUN
admet-995	1	151	and	and	CCONJ
admet-995	1	152	toxicity	toxicity	NOUN
admet-995	1	153	.	.	PUNCT
admet-995	2	1	to	to	PART
admet-995	2	2	reduce	reduce	VERB
admet-995	2	3	late	late	ADJ
admet-995	2	4	-	-	PUNCT
admet-995	2	5	stage	stage	NOUN
admet-995	2	6	failures	failure	NOUN
admet-995	2	7	in	in	ADP
admet-995	2	8	the	the	DET
admet-995	2	9	drug	drug	NOUN
admet-995	2	10	discovery	discovery	NOUN
admet-995	2	11	process	process	NOUN
admet-995	2	12	,	,	PUNCT
admet-995	2	13	it	it	PRON
admet-995	2	14	is	be	AUX
admet-995	2	15	essential	essential	ADJ
admet-995	2	16	to	to	PART
admet-995	2	17	estimate	estimate	VERB
admet-995	2	18	early	early	ADV
admet-995	2	19	the	the	DET
admet-995	2	20	probability	probability	NOUN
admet-995	2	21	of	of	ADP
admet-995	2	22	adverse	adverse	ADJ
admet-995	2	23	effects	effect	NOUN
admet-995	2	24	and	and	CCONJ
admet-995	2	25	potential	potential	ADJ
admet-995	2	26	toxicity	toxicity	NOUN
admet-995	2	27	.	.	PUNCT
admet-995	3	1	cardiotoxicity	cardiotoxicity	NOUN
admet-995	3	2	is	be	AUX
admet-995	3	3	one	one	NUM
admet-995	3	4	of	of	ADP
admet-995	3	5	the	the	DET
admet-995	3	6	most	most	ADV
admet-995	3	7	often	often	ADV
admet-995	3	8	observed	observe	VERB
admet-995	3	9	problems	problem	NOUN
admet-995	3	10	related	relate	VERB
admet-995	3	11	to	to	ADP
admet-995	3	12	a	a	DET
admet-995	3	13	compound	compound	NOUN
admet-995	3	14	's	's	PART
admet-995	3	15	inhibition	inhibition	NOUN
admet-995	3	16	of	of	ADP
admet-995	3	17	the	the	DET
admet-995	3	18	herg	herg	PROPN
admet-995	3	19	channel	channel	NOUN
admet-995	3	20	responsible	responsible	ADJ
admet-995	3	21	for	for	ADP
admet-995	3	22	the	the	DET
admet-995	3	23	potassium	potassium	NOUN
admet-995	3	24	cation	cation	NOUN
admet-995	3	25	flux	flux	NOUN
admet-995	3	26	.	.	PUNCT
admet-995	4	1	biomimetic	biomimetic	ADJ
admet-995	4	2	hplc	hplc	NOUN
admet-995	4	3	methods	method	NOUN
admet-995	4	4	can	can	AUX
admet-995	4	5	be	be	AUX
admet-995	4	6	used	use	VERB
admet-995	4	7	for	for	ADP
admet-995	4	8	the	the	DET
admet-995	4	9	early	early	ADJ
admet-995	4	10	screening	screening	NOUN
admet-995	4	11	of	of	ADP
admet-995	4	12	a	a	DET
admet-995	4	13	compound	compound	NOUN
admet-995	4	14	's	's	PART
admet-995	4	15	lipophilicity	lipophilicity	NOUN
admet-995	4	16	,	,	PUNCT
admet-995	4	17	protein	protein	NOUN
admet-995	4	18	binding	binding	NOUN
admet-995	4	19	and	and	CCONJ
admet-995	4	20	phospholipid	phospholipid	NOUN
admet-995	4	21	partition	partition	NOUN
admet-995	4	22	.	.	PUNCT
admet-995	5	1	based	base	VERB
admet-995	5	2	on	on	ADP
admet-995	5	3	the	the	DET
admet-995	5	4	published	publish	VERB
admet-995	5	5	herg	herg	PROPN
admet-995	5	6	pic50	pic50	PROPN
admet-995	5	7	data	datum	NOUN
admet-995	5	8	of	of	ADP
admet-995	5	9	90	90	NUM
admet-995	5	10	marketed	market	VERB
admet-995	5	11	drugs	drug	NOUN
admet-995	5	12	and	and	CCONJ
admet-995	5	13	their	their	PRON
admet-995	5	14	measured	measure	VERB
admet-995	5	15	biomimetic	biomimetic	ADJ
admet-995	5	16	properties	property	NOUN
admet-995	5	17	,	,	PUNCT
admet-995	5	18	a	a	DET
admet-995	5	19	model	model	NOUN
admet-995	5	20	has	have	AUX
admet-995	5	21	been	be	AUX
admet-995	5	22	developed	develop	VERB
admet-995	5	23	to	to	PART
admet-995	5	24	predict	predict	VERB
admet-995	5	25	the	the	DET
admet-995	5	26	herg	herg	PROPN
admet-995	5	27	inhibition	inhibition	NOUN
admet-995	5	28	using	use	VERB
admet-995	5	29	the	the	DET
admet-995	5	30	measured	measured	ADJ
admet-995	5	31	binding	binding	NOUN
admet-995	5	32	of	of	ADP
admet-995	5	33	compounds	compound	NOUN
admet-995	5	34	to	to	ADP
admet-995	5	35	alpha-1	alpha-1	NOUN
admet-995	5	36	-	-	PUNCT
admet-995	5	37	acid	acid	NOUN
admet-995	5	38	-	-	PUNCT
admet-995	5	39	glycoprotein	glycoprotein	NOUN
admet-995	5	40	(	(	PUNCT
admet-995	5	41	agp	agp	NOUN
admet-995	5	42	)	)	PUNCT
admet-995	5	43	and	and	CCONJ
admet-995	5	44	immobilised	immobilise	VERB
admet-995	5	45	artificial	artificial	ADJ
admet-995	5	46	membrane	membrane	NOUN
admet-995	5	47	(	(	PUNCT
admet-995	5	48	iam	iam	PROPN
admet-995	5	49	)	)	PUNCT
admet-995	5	50	.	.	PUNCT
admet-995	6	1	a	a	DET
admet-995	6	2	representative	representative	ADJ
admet-995	6	3	test	test	NOUN
admet-995	6	4	set	set	NOUN
admet-995	6	5	of	of	ADP
admet-995	6	6	16	16	NUM
admet-995	6	7	compounds	compound	NOUN
admet-995	6	8	was	be	AUX
admet-995	6	9	carefully	carefully	ADV
admet-995	6	10	selected	select	VERB
admet-995	6	11	.	.	PUNCT
admet-995	7	1	the	the	DET
admet-995	7	2	training	training	NOUN
admet-995	7	3	set	set	NOUN
admet-995	7	4	,	,	PUNCT
admet-995	7	5	involving	involve	VERB
admet-995	7	6	the	the	DET
admet-995	7	7	remaining	remain	VERB
admet-995	7	8	compounds	compound	NOUN
admet-995	7	9	,	,	PUNCT
admet-995	7	10	served	serve	VERB
admet-995	7	11	to	to	PART
admet-995	7	12	establish	establish	VERB
admet-995	7	13	the	the	DET
admet-995	7	14	linear	linear	ADJ
admet-995	7	15	model	model	NOUN
admet-995	7	16	.	.	PUNCT
admet-995	8	1	the	the	DET
admet-995	8	2	mechanistic	mechanistic	ADJ
admet-995	8	3	model	model	NOUN
admet-995	8	4	supports	support	VERB
admet-995	8	5	the	the	DET
admet-995	8	6	hypothesis	hypothesis	NOUN
admet-995	8	7	that	that	PRON
admet-995	8	8	compounds	compound	VERB
admet-995	8	9	have	have	VERB
admet-995	8	10	to	to	PART
admet-995	8	11	traverse	traverse	VERB
admet-995	8	12	the	the	DET
admet-995	8	13	cell	cell	NOUN
admet-995	8	14	membrane	membrane	NOUN
admet-995	8	15	and	and	CCONJ
admet-995	8	16	bind	bind	VERB
admet-995	8	17	to	to	ADP
admet-995	8	18	the	the	DET
admet-995	8	19	herg	herg	PROPN
admet-995	8	20	ion	ion	NOUN
admet-995	8	21	channel	channel	NOUN
admet-995	8	22	to	to	PART
admet-995	8	23	cause	cause	VERB
admet-995	8	24	the	the	DET
admet-995	8	25	inhibition	inhibition	NOUN
admet-995	8	26	.	.	PUNCT
admet-995	9	1	the	the	DET
admet-995	9	2	agp	agp	NOUN
admet-995	9	3	and	and	CCONJ
admet-995	9	4	the	the	DET
admet-995	9	5	herg	herg	PROPN
admet-995	9	6	ion	ion	NOUN
admet-995	9	7	channel	channel	NOUN
admet-995	9	8	show	show	VERB
admet-995	9	9	structural	structural	ADJ
admet-995	9	10	similarity	similarity	NOUN
admet-995	9	11	,	,	PUNCT
admet-995	9	12	as	as	SCONJ
admet-995	9	13	both	both	PRON
admet-995	9	14	bind	bind	VERB
admet-995	9	15	positively	positively	ADV
admet-995	9	16	charged	charge	VERB
admet-995	9	17	compounds	compound	NOUN
admet-995	9	18	with	with	ADP
admet-995	9	19	strong	strong	ADJ
admet-995	9	20	shape	shape	NOUN
admet-995	9	21	selectivity	selectivity	NOUN
admet-995	9	22	.	.	PUNCT
admet-995	10	1	in	in	ADP
admet-995	10	2	contrast	contrast	NOUN
admet-995	10	3	,	,	PUNCT
admet-995	10	4	a	a	DET
admet-995	10	5	good	good	ADJ
admet-995	10	6	iam	iam	PROPN
admet-995	10	7	partition	partition	NOUN
admet-995	10	8	is	be	AUX
admet-995	10	9	a	a	DET
admet-995	10	10	prerequisite	prerequisite	NOUN
admet-995	10	11	for	for	ADP
admet-995	10	12	cell	cell	NOUN
admet-995	10	13	membrane	membrane	NOUN
admet-995	10	14	traversal	traversal	NOUN
admet-995	10	15	.	.	PUNCT
admet-995	11	1	for	for	ADP
admet-995	11	2	reasons	reason	NOUN
admet-995	11	3	of	of	ADP
admet-995	11	4	comparison	comparison	NOUN
admet-995	11	5	,	,	PUNCT
admet-995	11	6	a	a	DET
admet-995	11	7	corresponding	corresponding	ADJ
admet-995	11	8	model	model	NOUN
admet-995	11	9	was	be	AUX
admet-995	11	10	derived	derive	VERB
admet-995	11	11	by	by	ADP
admet-995	11	12	replacing	replace	VERB
admet-995	11	13	the	the	DET
admet-995	11	14	measured	measure	VERB
admet-995	11	15	biomimetic	biomimetic	ADJ
admet-995	11	16	properties	property	NOUN
admet-995	11	17	with	with	ADP
admet-995	11	18	calculated	calculate	VERB
admet-995	11	19	physicochemical	physicochemical	ADJ
admet-995	11	20	properties	property	NOUN
admet-995	11	21	.	.	PUNCT
admet-995	12	1	the	the	DET
admet-995	12	2	model	model	NOUN
admet-995	12	3	established	establish	VERB
admet-995	12	4	with	with	ADP
admet-995	12	5	the	the	DET
admet-995	12	6	measured	measure	VERB
admet-995	12	7	biomimetic	biomimetic	ADJ
admet-995	12	8	binding	bind	VERB
admet-995	12	9	properties	property	NOUN
admet-995	12	10	proved	prove	VERB
admet-995	12	11	to	to	PART
admet-995	12	12	be	be	AUX
admet-995	12	13	superior	superior	ADJ
admet-995	12	14	and	and	CCONJ
admet-995	12	15	can	can	AUX
admet-995	12	16	explain	explain	VERB
admet-995	12	17	over	over	ADP
admet-995	12	18	70	70	NUM
admet-995	12	19	%	%	NOUN
admet-995	12	20	of	of	ADP
admet-995	12	21	the	the	DET
admet-995	12	22	variance	variance	NOUN
admet-995	12	23	of	of	ADP
admet-995	12	24	the	the	DET
admet-995	12	25	herg	herg	PROPN
admet-995	12	26	pic50	pic50	PROPN
admet-995	12	27	values	value	NOUN
admet-995	12	28	.	.	PUNCT
admet-995	13	1	©	©	NOUN
admet-995	13	2	2021	2021	NUM
admet-995	13	3	by	by	ADP
admet-995	13	4	the	the	DET
admet-995	13	5	authors	author	NOUN
admet-995	13	6	.	.	PUNCT
admet-995	14	1	this	this	DET
admet-995	14	2	article	article	NOUN
admet-995	14	3	is	be	AUX
admet-995	14	4	an	an	DET
admet-995	14	5	open	open	ADJ
admet-995	14	6	-	-	PUNCT
admet-995	14	7	access	access	NOUN
admet-995	14	8	article	article	NOUN
admet-995	14	9	distributed	distribute	VERB
admet-995	14	10	under	under	ADP
admet-995	14	11	the	the	DET
admet-995	14	12	terms	term	NOUN
admet-995	14	13	and	and	CCONJ
admet-995	14	14	conditions	condition	NOUN
admet-995	14	15	of	of	ADP
admet-995	14	16	the	the	DET
admet-995	14	17	creative	creative	ADJ
admet-995	14	18	commons	common	NOUN
admet-995	14	19	attribution	attribution	NOUN
admet-995	14	20	license	license	NOUN
admet-995	14	21	(	(	PUNCT
admet-995	14	22	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-995	14	23	)	)	PUNCT
admet-995	14	24	.	.	PUNCT
admet-995	15	1	keywords	keyword	VERB
admet-995	15	2	cardiotoxicity	cardiotoxicity	NOUN
admet-995	15	3	;	;	PUNCT
admet-995	16	1	proarrhythmia	proarrhythmia	NOUN
admet-995	16	2	;	;	PUNCT
admet-995	16	3	qt	qt	NOUN
admet-995	16	4	prolongation	prolongation	NOUN
admet-995	16	5	;	;	PUNCT
admet-995	16	6	torsades	torsade	NOUN
admet-995	16	7	de	de	ADP
admet-995	16	8	pointes	pointe	NOUN
admet-995	16	9	;	;	PUNCT
admet-995	16	10	herg	herg	NOUN
admet-995	16	11	inhibition	inhibition	NOUN
admet-995	16	12	;	;	PUNCT
admet-995	16	13	iam	iam	PROPN
admet-995	16	14	binding	bind	VERB
admet-995	16	15	,	,	PUNCT
admet-995	16	16	agp	agp	NOUN
admet-995	16	17	binding	bind	VERB
admet-995	16	18	introduction	introduction	NOUN
admet-995	16	19	it	it	PRON
admet-995	16	20	has	have	AUX
admet-995	16	21	been	be	AUX
admet-995	16	22	recognised	recognise	VERB
admet-995	16	23	that	that	SCONJ
admet-995	16	24	the	the	DET
admet-995	16	25	physicochemical	physicochemical	ADJ
admet-995	16	26	properties	property	NOUN
admet-995	16	27	of	of	ADP
admet-995	16	28	drug	drug	NOUN
admet-995	16	29	candidates	candidate	NOUN
admet-995	16	30	can	can	AUX
admet-995	16	31	be	be	AUX
admet-995	16	32	related	relate	VERB
admet-995	16	33	to	to	ADP
admet-995	16	34	the	the	DET
admet-995	16	35	latestage	latestage	NOUN
admet-995	16	36	attrition	attrition	NOUN
admet-995	16	37	of	of	ADP
admet-995	16	38	compounds	compound	NOUN
admet-995	16	39	in	in	ADP
admet-995	16	40	the	the	DET
admet-995	16	41	drug	drug	NOUN
admet-995	16	42	development	development	NOUN
admet-995	16	43	process	process	NOUN
admet-995	16	44	.	.	PUNCT
admet-995	17	1	the	the	DET
admet-995	17	2	early	early	ADJ
admet-995	17	3	problems	problem	NOUN
admet-995	17	4	with	with	ADP
admet-995	17	5	bioavailability	bioavailability	NOUN
admet-995	17	6	and	and	CCONJ
admet-995	17	7	absorption	absorption	NOUN
admet-995	17	8	have	have	AUX
admet-995	17	9	been	be	AUX
admet-995	17	10	successfully	successfully	ADV
admet-995	17	11	improved	improve	VERB
admet-995	17	12	by	by	ADP
admet-995	17	13	optimising	optimise	VERB
admet-995	17	14	solubility	solubility	NOUN
admet-995	17	15	and	and	CCONJ
admet-995	17	16	permeability	permeability	NOUN
admet-995	17	17	[	[	X
admet-995	17	18	1	1	NUM
admet-995	17	19	]	]	PUNCT
admet-995	17	20	.	.	PUNCT
admet-995	18	1	recently	recently	ADV
admet-995	18	2	,	,	PUNCT
admet-995	18	3	toxicity	toxicity	NOUN
admet-995	18	4	and	and	CCONJ
admet-995	18	5	the	the	DET
admet-995	18	6	lack	lack	NOUN
admet-995	18	7	of	of	ADP
admet-995	18	8	efficacy	efficacy	NOUN
admet-995	18	9	have	have	AUX
admet-995	18	10	been	be	AUX
admet-995	18	11	identified	identify	VERB
admet-995	18	12	as	as	ADP
admet-995	18	13	the	the	DET
admet-995	18	14	major	major	ADJ
admet-995	18	15	cause	cause	NOUN
admet-995	18	16	of	of	ADP
admet-995	18	17	compound	compound	NOUN
admet-995	18	18	attrition	attrition	NOUN
admet-995	18	19	in	in	ADP
admet-995	18	20	clinics	clinic	NOUN
admet-995	18	21	.	.	PUNCT
admet-995	19	1	together	together	ADV
admet-995	19	2	,	,	PUNCT
admet-995	19	3	preclinical	preclinical	ADJ
admet-995	19	4	toxicity	toxicity	NOUN
admet-995	19	5	and	and	CCONJ
admet-995	19	6	adverse	adverse	ADJ
admet-995	19	7	events	event	NOUN
admet-995	19	8	account	account	VERB
admet-995	19	9	for	for	ADP
admet-995	19	10	approximately	approximately	ADV
admet-995	19	11	one	one	NUM
admet-995	19	12	-	-	PUNCT
admet-995	19	13	third	third	NOUN
admet-995	19	14	of	of	ADP
admet-995	19	15	all	all	DET
admet-995	19	16	attrition	attrition	NOUN
admet-995	19	17	cases	case	NOUN
admet-995	19	18	[	[	X
admet-995	19	19	2	2	NUM
admet-995	19	20	]	]	PUNCT
admet-995	19	21	.	.	PUNCT
admet-995	20	1	http://dx.doi.org/10.5599/admet.995	http://dx.doi.org/10.5599/admet.995	PROPN
admet-995	20	2	https://doi.org/10.5599/admet.995	https://doi.org/10.5599/admet.995	PROPN
admet-995	21	1	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	PROPN
admet-995	21	2	mailto:chrisxp3@hotmail.com	mailto:chrisxp3@hotmail.com	X
admet-995	21	3	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-995	21	4	stergiopoulos	stergiopoulos	PROPN
admet-995	21	5	,	,	PUNCT
admet-995	21	6	tsopelas	tsopela	NOUN
admet-995	21	7	and	and	CCONJ
admet-995	21	8	valko	valko	PROPN
admet-995	21	9	admet	admet	PROPN
admet-995	21	10	&	&	CCONJ
admet-995	21	11	dmpk	dmpk	PROPN
admet-995	21	12	9(3	9(3	NUM
admet-995	21	13	)	)	PUNCT
admet-995	21	14	(	(	PUNCT
admet-995	21	15	2021	2021	NUM
admet-995	21	16	)	)	PUNCT
admet-995	21	17	191	191	NUM
admet-995	21	18	-	-	SYM
admet-995	21	19	207	207	NUM
admet-995	21	20	192	192	NUM
admet-995	21	21	cardiotoxicity	cardiotoxicity	NOUN
admet-995	21	22	is	be	AUX
admet-995	21	23	one	one	NUM
admet-995	21	24	of	of	ADP
admet-995	21	25	the	the	DET
admet-995	21	26	major	major	ADJ
admet-995	21	27	causes	cause	NOUN
admet-995	21	28	of	of	ADP
admet-995	21	29	concern	concern	NOUN
admet-995	21	30	during	during	ADP
admet-995	21	31	clinical	clinical	ADJ
admet-995	21	32	trials	trial	NOUN
admet-995	21	33	together	together	ADV
admet-995	21	34	with	with	ADP
admet-995	21	35	liver	liver	NOUN
admet-995	21	36	and	and	CCONJ
admet-995	21	37	central	central	ADJ
admet-995	21	38	nervous	nervous	ADJ
admet-995	21	39	system	system	NOUN
admet-995	21	40	(	(	PUNCT
admet-995	21	41	cns	cns	NOUN
admet-995	21	42	)	)	PUNCT
admet-995	21	43	toxicity	toxicity	NOUN
admet-995	21	44	[	[	X
admet-995	21	45	3	3	NUM
admet-995	21	46	]	]	PUNCT
admet-995	21	47	.	.	PUNCT
admet-995	22	1	it	it	PRON
admet-995	22	2	accounts	account	VERB
admet-995	22	3	for	for	ADP
admet-995	22	4	approximately	approximately	ADV
admet-995	22	5	27	27	NUM
admet-995	22	6	%	%	NOUN
admet-995	22	7	of	of	ADP
admet-995	22	8	drug	drug	NOUN
admet-995	22	9	development	development	NOUN
admet-995	22	10	failures	failure	NOUN
admet-995	22	11	,	,	PUNCT
admet-995	22	12	and	and	CCONJ
admet-995	22	13	it	it	PRON
admet-995	22	14	does	do	AUX
admet-995	22	15	not	not	PART
admet-995	22	16	seem	seem	VERB
admet-995	22	17	to	to	PART
admet-995	22	18	be	be	AUX
admet-995	22	19	restricted	restrict	VERB
admet-995	22	20	to	to	ADP
admet-995	22	21	specific	specific	ADJ
admet-995	22	22	high	high	ADJ
admet-995	22	23	-	-	PUNCT
admet-995	22	24	risk	risk	NOUN
admet-995	22	25	therapeutic	therapeutic	ADJ
admet-995	22	26	areas	area	NOUN
admet-995	22	27	[	[	X
admet-995	22	28	4	4	NUM
admet-995	22	29	]	]	PUNCT
admet-995	22	30	.	.	PUNCT
admet-995	23	1	one	one	NUM
admet-995	23	2	particular	particular	ADJ
admet-995	23	3	focus	focus	NOUN
admet-995	23	4	of	of	ADP
admet-995	23	5	cardiovascular	cardiovascular	ADJ
admet-995	23	6	adverse	adverse	ADJ
admet-995	23	7	effects	effect	NOUN
admet-995	23	8	has	have	AUX
admet-995	23	9	been	be	AUX
admet-995	23	10	drug	drug	NOUN
admet-995	23	11	-	-	PUNCT
admet-995	23	12	induced	induce	VERB
admet-995	23	13	arrhythmia	arrhythmia	NOUN
admet-995	23	14	or	or	CCONJ
admet-995	23	15	"	"	PUNCT
admet-995	23	16	proarrhythmia	proarrhythmia	NOUN
admet-995	23	17	"	"	PUNCT
admet-995	23	18	as	as	ADP
admet-995	23	19	a	a	DET
admet-995	23	20	consequence	consequence	NOUN
admet-995	23	21	of	of	ADP
admet-995	23	22	an	an	DET
admet-995	23	23	increased	increase	VERB
admet-995	23	24	recognition	recognition	NOUN
admet-995	23	25	of	of	ADP
admet-995	23	26	a	a	DET
admet-995	23	27	relationship	relationship	NOUN
admet-995	23	28	between	between	ADP
admet-995	23	29	drug	drug	NOUN
admet-995	23	30	-	-	PUNCT
admet-995	23	31	induced	induce	VERB
admet-995	23	32	qt	qt	NOUN
admet-995	23	33	interval	interval	NOUN
admet-995	23	34	prolongation	prolongation	NOUN
admet-995	23	35	and	and	CCONJ
admet-995	23	36	torsades	torsade	NOUN
admet-995	23	37	de	de	X
admet-995	23	38	pointes	pointe	NOUN
admet-995	23	39	(	(	PUNCT
admet-995	23	40	tdp	tdp	NOUN
admet-995	23	41	)	)	PUNCT
admet-995	24	1	[	[	X
admet-995	24	2	5	5	NUM
admet-995	24	3	]	]	PUNCT
admet-995	24	4	.	.	PUNCT
admet-995	25	1	tdp	tdp	NOUN
admet-995	25	2	is	be	AUX
admet-995	25	3	a	a	DET
admet-995	25	4	dangerous	dangerous	ADJ
admet-995	25	5	type	type	NOUN
admet-995	25	6	of	of	ADP
admet-995	25	7	proarrhythmia	proarrhythmia	NOUN
admet-995	25	8	,	,	PUNCT
admet-995	25	9	described	describe	VERB
admet-995	25	10	as	as	ADP
admet-995	25	11	a	a	DET
admet-995	25	12	rare	rare	ADJ
admet-995	25	13	ventricular	ventricular	ADJ
admet-995	25	14	tachycardia	tachycardia	NOUN
admet-995	25	15	with	with	ADP
admet-995	25	16	potential	potential	ADJ
admet-995	25	17	sudden	sudden	ADJ
admet-995	25	18	cardiac	cardiac	ADJ
admet-995	25	19	death	death	NOUN
admet-995	25	20	,	,	PUNCT
admet-995	25	21	which	which	PRON
admet-995	25	22	has	have	AUX
admet-995	25	23	led	lead	VERB
admet-995	25	24	to	to	ADP
admet-995	25	25	approximately	approximately	ADV
admet-995	25	26	one	one	NUM
admet-995	25	27	-	-	PUNCT
admet-995	25	28	third	third	NOUN
admet-995	25	29	of	of	ADP
admet-995	25	30	all	all	DET
admet-995	25	31	drug	drug	NOUN
admet-995	25	32	withdrawals	withdrawal	NOUN
admet-995	25	33	between	between	ADP
admet-995	25	34	1990	1990	NUM
admet-995	25	35	and	and	CCONJ
admet-995	25	36	2006	2006	NUM
admet-995	25	37	[	[	X
admet-995	25	38	4	4	NUM
admet-995	25	39	]	]	PUNCT
admet-995	25	40	.	.	PUNCT
admet-995	26	1	furthermore	furthermore	ADV
admet-995	26	2	,	,	PUNCT
admet-995	26	3	15	15	NUM
admet-995	26	4	%	%	NOUN
admet-995	26	5	of	of	ADP
admet-995	26	6	drugs	drug	NOUN
admet-995	26	7	still	still	ADV
admet-995	26	8	on	on	ADP
admet-995	26	9	the	the	DET
admet-995	26	10	market	market	NOUN
admet-995	26	11	can	can	AUX
admet-995	26	12	cause	cause	VERB
admet-995	26	13	qt	qt	NOUN
admet-995	26	14	prolongation	prolongation	NOUN
admet-995	26	15	,	,	PUNCT
admet-995	26	16	and	and	CCONJ
admet-995	26	17	4	4	NUM
admet-995	26	18	%	%	NOUN
admet-995	26	19	are	be	AUX
admet-995	26	20	associated	associate	VERB
admet-995	26	21	with	with	ADP
admet-995	26	22	tdp	tdp	NOUN
admet-995	26	23	arrhythmia	arrhythmia	NOUN
admet-995	26	24	risk	risk	NOUN
admet-995	26	25	.	.	PUNCT
admet-995	27	1	therefore	therefore	ADV
admet-995	27	2	,	,	PUNCT
admet-995	27	3	it	it	PRON
admet-995	27	4	is	be	AUX
admet-995	27	5	important	important	ADJ
admet-995	27	6	to	to	PART
admet-995	27	7	recognize	recognize	VERB
admet-995	27	8	a	a	DET
admet-995	27	9	compound	compound	NOUN
admet-995	27	10	’s	’s	PART
admet-995	27	11	cardiotoxicity	cardiotoxicity	NOUN
admet-995	27	12	potential	potential	NOUN
admet-995	27	13	early	early	ADV
admet-995	27	14	in	in	ADP
admet-995	27	15	the	the	DET
admet-995	27	16	drug	drug	NOUN
admet-995	27	17	discovery	discovery	NOUN
admet-995	27	18	process	process	NOUN
admet-995	27	19	,	,	PUNCT
admet-995	27	20	not	not	PART
admet-995	27	21	only	only	ADV
admet-995	27	22	because	because	SCONJ
admet-995	27	23	of	of	ADP
admet-995	27	24	the	the	DET
admet-995	27	25	associated	associated	ADJ
admet-995	27	26	loss	loss	NOUN
admet-995	27	27	of	of	ADP
admet-995	27	28	human	human	ADJ
admet-995	27	29	life	life	NOUN
admet-995	27	30	or	or	CCONJ
admet-995	27	31	health	health	NOUN
admet-995	27	32	,	,	PUNCT
admet-995	27	33	but	but	CCONJ
admet-995	27	34	also	also	ADV
admet-995	27	35	because	because	SCONJ
admet-995	27	36	of	of	ADP
admet-995	27	37	the	the	DET
admet-995	27	38	enormous	enormous	ADJ
admet-995	27	39	financial	financial	ADJ
admet-995	27	40	loss	loss	NOUN
admet-995	27	41	in	in	ADP
admet-995	27	42	investment	investment	NOUN
admet-995	27	43	and	and	CCONJ
admet-995	27	44	future	future	ADJ
admet-995	27	45	revenue	revenue	NOUN
admet-995	27	46	potential	potential	NOUN
admet-995	27	47	[	[	X
admet-995	27	48	6	6	NUM
admet-995	27	49	]	]	PUNCT
admet-995	27	50	.	.	PUNCT
admet-995	28	1	the	the	DET
admet-995	28	2	cardiac	cardiac	ADJ
admet-995	28	3	action	action	NOUN
admet-995	28	4	potential	potential	NOUN
admet-995	28	5	is	be	AUX
admet-995	28	6	regulated	regulate	VERB
admet-995	28	7	by	by	ADP
admet-995	28	8	the	the	DET
admet-995	28	9	electrical	electrical	ADJ
admet-995	28	10	current	current	ADJ
admet-995	28	11	flows	flow	NOUN
admet-995	28	12	of	of	ADP
admet-995	28	13	ions	ion	NOUN
admet-995	28	14	across	across	ADP
admet-995	28	15	cardiomyocyte	cardiomyocyte	NOUN
admet-995	28	16	membranes	membrane	NOUN
admet-995	28	17	.	.	PUNCT
admet-995	29	1	many	many	ADJ
admet-995	29	2	drugs	drug	NOUN
admet-995	29	3	can	can	AUX
admet-995	29	4	bind	bind	VERB
admet-995	29	5	to	to	ADP
admet-995	29	6	ion	ion	NOUN
admet-995	29	7	channels	channel	NOUN
admet-995	29	8	,	,	PUNCT
admet-995	29	9	block	block	VERB
admet-995	29	10	ionic	ionic	ADJ
admet-995	29	11	flow	flow	NOUN
admet-995	29	12	and	and	CCONJ
admet-995	29	13	disrupt	disrupt	VERB
admet-995	29	14	the	the	DET
admet-995	29	15	regulation	regulation	NOUN
admet-995	29	16	of	of	ADP
admet-995	29	17	the	the	DET
admet-995	29	18	action	action	NOUN
admet-995	29	19	potential	potential	NOUN
admet-995	29	20	[	[	X
admet-995	29	21	7	7	NUM
admet-995	29	22	]	]	PUNCT
admet-995	29	23	.	.	PUNCT
admet-995	30	1	upon	upon	SCONJ
admet-995	30	2	blockade	blockade	NOUN
admet-995	30	3	,	,	PUNCT
admet-995	30	4	the	the	DET
admet-995	30	5	action	action	NOUN
admet-995	30	6	potential	potential	NOUN
admet-995	30	7	will	will	AUX
admet-995	30	8	rest	rest	VERB
admet-995	30	9	longer	long	ADV
admet-995	30	10	,	,	PUNCT
admet-995	30	11	which	which	PRON
admet-995	30	12	results	result	VERB
admet-995	30	13	in	in	ADP
admet-995	30	14	an	an	DET
admet-995	30	15	increased	increase	VERB
admet-995	30	16	duration	duration	NOUN
admet-995	30	17	of	of	ADP
admet-995	30	18	the	the	DET
admet-995	30	19	relative	relative	ADJ
admet-995	30	20	qt	qt	NOUN
admet-995	30	21	interval	interval	NOUN
admet-995	30	22	that	that	PRON
admet-995	30	23	can	can	AUX
admet-995	30	24	be	be	AUX
admet-995	30	25	observed	observe	VERB
admet-995	30	26	in	in	ADP
admet-995	30	27	electrocardiograph	electrocardiograph	NOUN
admet-995	30	28	(	(	PUNCT
admet-995	30	29	ecg	ecg	PROPN
admet-995	30	30	)	)	PUNCT
admet-995	30	31	traces	trace	NOUN
admet-995	30	32	.	.	PUNCT
admet-995	31	1	disturbing	disturb	VERB
admet-995	31	2	the	the	DET
admet-995	31	3	qt	qt	NOUN
admet-995	31	4	interval	interval	NOUN
admet-995	31	5	may	may	AUX
admet-995	31	6	lead	lead	VERB
admet-995	31	7	to	to	ADP
admet-995	31	8	instability	instability	NOUN
admet-995	31	9	in	in	ADP
admet-995	31	10	the	the	DET
admet-995	31	11	heart	heart	NOUN
admet-995	31	12	rhythm	rhythm	NOUN
admet-995	31	13	[	[	X
admet-995	31	14	8	8	NUM
admet-995	31	15	]	]	PUNCT
admet-995	31	16	.	.	PUNCT
admet-995	32	1	patients	patient	NOUN
admet-995	32	2	with	with	ADP
admet-995	32	3	long	long	ADJ
admet-995	32	4	qt	qt	NOUN
admet-995	32	5	syndrome	syndrome	NOUN
admet-995	32	6	(	(	PUNCT
admet-995	32	7	lqts	lqts	NOUN
admet-995	32	8	)	)	PUNCT
admet-995	32	9	exhibit	exhibit	VERB
admet-995	32	10	a	a	DET
admet-995	32	11	significant	significant	ADJ
admet-995	32	12	predisposition	predisposition	NOUN
admet-995	32	13	for	for	ADP
admet-995	32	14	the	the	DET
admet-995	32	15	tdp	tdp	NOUN
admet-995	32	16	type	type	NOUN
admet-995	32	17	's	's	PART
admet-995	32	18	cardiac	cardiac	ADJ
admet-995	32	19	arrhythmia	arrhythmia	NOUN
admet-995	33	1	[	[	X
admet-995	33	2	9	9	NUM
admet-995	33	3	]	]	PUNCT
admet-995	33	4	.	.	PUNCT
admet-995	34	1	a	a	DET
admet-995	34	2	prolongation	prolongation	NOUN
admet-995	34	3	of	of	ADP
admet-995	34	4	the	the	DET
admet-995	34	5	cardiac	cardiac	ADJ
admet-995	34	6	action	action	NOUN
admet-995	34	7	potential	potential	NOUN
admet-995	34	8	and	and	CCONJ
admet-995	34	9	the	the	DET
admet-995	34	10	qt	qt	NOUN
admet-995	34	11	interval	interval	NOUN
admet-995	34	12	has	have	AUX
admet-995	34	13	been	be	AUX
admet-995	34	14	associated	associate	VERB
admet-995	34	15	with	with	ADP
admet-995	34	16	loss	loss	NOUN
admet-995	34	17	of	of	ADP
admet-995	34	18	function	function	NOUN
admet-995	34	19	or	or	CCONJ
admet-995	34	20	drug	drug	NOUN
admet-995	34	21	-	-	PUNCT
admet-995	34	22	trapping	trapping	NOUN
admet-995	34	23	inside	inside	ADP
admet-995	34	24	the	the	DET
admet-995	34	25	central	central	ADJ
admet-995	34	26	cavity	cavity	NOUN
admet-995	34	27	of	of	ADP
admet-995	34	28	the	the	DET
admet-995	34	29	kv11.1	kv11.1	NOUN
admet-995	34	30	[	[	X
admet-995	34	31	10	10	NUM
admet-995	34	32	]	]	PUNCT
admet-995	34	33	potassium	potassium	NOUN
admet-995	34	34	channel	channel	NOUN
admet-995	34	35	,	,	PUNCT
admet-995	34	36	which	which	PRON
admet-995	34	37	is	be	AUX
admet-995	34	38	encoded	encode	VERB
admet-995	34	39	by	by	ADP
admet-995	34	40	herg	herg	PROPN
admet-995	34	41	(	(	PUNCT
admet-995	34	42	human	human	ADJ
admet-995	34	43	ether	ether	NOUN
admet-995	34	44	-	-	PUNCT
admet-995	34	45	a	a	DET
admet-995	34	46	-	-	PUNCT
admet-995	34	47	go	go	NOUN
admet-995	34	48	-	-	PUNCT
admet-995	34	49	go	go	VERB
admet-995	34	50	related	related	ADJ
admet-995	34	51	gene	gene	NOUN
admet-995	34	52	)	)	PUNCT
admet-995	34	53	and	and	CCONJ
admet-995	34	54	carries	carry	VERB
admet-995	34	55	the	the	DET
admet-995	34	56	rapid	rapid	ADJ
admet-995	34	57	delayed	delay	VERB
admet-995	34	58	rectifier	rectifier	NOUN
admet-995	34	59	potassium	potassium	NOUN
admet-995	34	60	current	current	NOUN
admet-995	34	61	(	(	PUNCT
admet-995	34	62	ikr	ikr	INTJ
admet-995	34	63	)	)	PUNCT
admet-995	35	1	[	[	X
admet-995	35	2	7,11	7,11	X
admet-995	35	3	]	]	X
admet-995	35	4	.	.	PUNCT
admet-995	36	1	this	this	DET
admet-995	36	2	channel	channel	NOUN
admet-995	36	3	has	have	VERB
admet-995	36	4	a	a	DET
admet-995	36	5	tetrameric	tetrameric	ADJ
admet-995	36	6	structure	structure	NOUN
admet-995	36	7	formed	form	VERB
admet-995	36	8	by	by	ADP
admet-995	36	9	co	co	NOUN
admet-995	36	10	-	-	NOUN
admet-995	36	11	assembly	assembly	NOUN
admet-995	36	12	of	of	ADP
admet-995	36	13	four	four	NUM
admet-995	36	14	identical	identical	ADJ
admet-995	36	15	subunits	subunit	NOUN
admet-995	36	16	,	,	PUNCT
admet-995	36	17	each	each	PRON
admet-995	36	18	composed	compose	VERB
admet-995	36	19	of	of	ADP
admet-995	36	20	six	six	NUM
admet-995	36	21	helical	helical	ADJ
admet-995	36	22	transmembrane	transmembrane	NOUN
admet-995	36	23	domains	domain	NOUN
admet-995	36	24	(	(	PUNCT
admet-995	36	25	denoted	denote	VERB
admet-995	36	26	s1	s1	NOUN
admet-995	36	27	–	–	PUNCT
admet-995	36	28	s6	s6	PROPN
admet-995	36	29	)	)	PUNCT
admet-995	36	30	.	.	PUNCT
admet-995	37	1	the	the	DET
admet-995	37	2	s4	s4	PROPN
admet-995	37	3	domain	domain	NOUN
admet-995	37	4	contains	contain	VERB
admet-995	37	5	six	six	NUM
admet-995	37	6	positive	positive	ADJ
admet-995	37	7	charges	charge	NOUN
admet-995	37	8	,	,	PUNCT
admet-995	37	9	typical	typical	ADJ
admet-995	37	10	for	for	ADP
admet-995	37	11	voltage	voltage	NOUN
admet-995	37	12	-	-	PUNCT
admet-995	37	13	gated	gate	VERB
admet-995	37	14	k	k	NOUN
admet-995	37	15	+	+	CCONJ
admet-995	37	16	channels	channel	NOUN
admet-995	37	17	[	[	X
admet-995	37	18	12	12	NUM
admet-995	37	19	]	]	PUNCT
admet-995	37	20	.	.	PUNCT
admet-995	38	1	the	the	DET
admet-995	38	2	channel	channel	NOUN
admet-995	38	3	pore	pore	NOUN
admet-995	38	4	is	be	AUX
admet-995	38	5	asymmetrical	asymmetrical	ADJ
admet-995	38	6	,	,	PUNCT
admet-995	38	7	and	and	CCONJ
admet-995	38	8	its	its	PRON
admet-995	38	9	dimensions	dimension	NOUN
admet-995	38	10	change	change	VERB
admet-995	38	11	depending	depend	VERB
admet-995	38	12	on	on	ADP
admet-995	38	13	its	its	PRON
admet-995	38	14	state	state	NOUN
admet-995	38	15	(	(	PUNCT
admet-995	38	16	open	open	ADJ
admet-995	38	17	-	-	PUNCT
admet-995	38	18	closed	closed	ADJ
admet-995	38	19	-	-	PUNCT
admet-995	38	20	inactivated	inactivate	VERB
admet-995	38	21	)	)	PUNCT
admet-995	38	22	.	.	PUNCT
admet-995	39	1	the	the	DET
admet-995	39	2	herg	herg	PROPN
admet-995	39	3	channel	channel	NOUN
admet-995	39	4	has	have	AUX
admet-995	39	5	been	be	AUX
admet-995	39	6	shown	show	VERB
admet-995	39	7	to	to	PART
admet-995	39	8	interact	interact	VERB
admet-995	39	9	with	with	ADP
admet-995	39	10	a	a	DET
admet-995	39	11	wide	wide	ADJ
admet-995	39	12	range	range	NOUN
admet-995	39	13	of	of	ADP
admet-995	39	14	drugs	drug	NOUN
admet-995	39	15	owing	owe	VERB
admet-995	39	16	to	to	ADP
admet-995	39	17	the	the	DET
admet-995	39	18	unique	unique	ADJ
admet-995	39	19	shape	shape	NOUN
admet-995	39	20	of	of	ADP
admet-995	39	21	the	the	DET
admet-995	39	22	ligand	ligand	NOUN
admet-995	39	23	-	-	PUNCT
admet-995	39	24	binding	bind	VERB
admet-995	39	25	site	site	NOUN
admet-995	39	26	,	,	PUNCT
admet-995	39	27	its	its	PRON
admet-995	39	28	hydrophobic	hydrophobic	NOUN
admet-995	39	29	character	character	NOUN
admet-995	39	30	and	and	CCONJ
admet-995	39	31	the	the	DET
admet-995	39	32	large	large	ADJ
admet-995	39	33	vestibule	vestibule	NOUN
admet-995	39	34	of	of	ADP
admet-995	39	35	the	the	DET
admet-995	39	36	channel	channel	NOUN
admet-995	39	37	[	[	X
admet-995	39	38	13,14	13,14	NUM
admet-995	39	39	]	]	PUNCT
admet-995	39	40	.	.	PUNCT
admet-995	40	1	the	the	DET
admet-995	40	2	risk	risk	NOUN
admet-995	40	3	tolerance	tolerance	NOUN
admet-995	40	4	for	for	ADP
admet-995	40	5	qt	qt	NOUN
admet-995	40	6	prolongation	prolongation	NOUN
admet-995	40	7	may	may	AUX
admet-995	40	8	vary	vary	VERB
admet-995	40	9	significantly	significantly	ADV
admet-995	40	10	depending	depend	VERB
admet-995	40	11	on	on	ADP
admet-995	40	12	the	the	DET
admet-995	40	13	dose	dose	NOUN
admet-995	40	14	and	and	CCONJ
admet-995	40	15	indication	indication	NOUN
admet-995	40	16	of	of	ADP
admet-995	40	17	the	the	DET
admet-995	40	18	drug	drug	NOUN
admet-995	40	19	.	.	PUNCT
admet-995	41	1	documented	document	VERB
admet-995	41	2	herg	herg	PROPN
admet-995	41	3	-	-	PUNCT
admet-995	41	4	blocking	block	VERB
admet-995	41	5	activity	activity	NOUN
admet-995	41	6	reduces	reduce	VERB
admet-995	41	7	the	the	DET
admet-995	41	8	value	value	NOUN
admet-995	41	9	of	of	ADP
admet-995	41	10	a	a	DET
admet-995	41	11	molecule	molecule	NOUN
admet-995	41	12	,	,	PUNCT
admet-995	41	13	as	as	SCONJ
admet-995	41	14	it	it	PRON
admet-995	41	15	increases	increase	VERB
admet-995	41	16	the	the	DET
admet-995	41	17	risk	risk	NOUN
admet-995	41	18	of	of	ADP
admet-995	41	19	clinical	clinical	ADJ
admet-995	41	20	failure	failure	NOUN
admet-995	41	21	.	.	PUNCT
admet-995	42	1	it	it	PRON
admet-995	42	2	has	have	AUX
admet-995	42	3	also	also	ADV
admet-995	42	4	been	be	AUX
admet-995	42	5	estimated	estimate	VERB
admet-995	42	6	that	that	SCONJ
admet-995	42	7	about	about	ADV
admet-995	42	8	60	60	NUM
admet-995	42	9	%	%	NOUN
admet-995	42	10	of	of	ADP
admet-995	42	11	drugs	drug	NOUN
admet-995	42	12	in	in	ADP
admet-995	42	13	development	development	NOUN
admet-995	42	14	exhibit	exhibit	PROPN
admet-995	42	15	herg	herg	PROPN
admet-995	42	16	block	block	NOUN
admet-995	42	17	[	[	X
admet-995	42	18	11	11	NUM
admet-995	42	19	]	]	PUNCT
admet-995	42	20	.	.	PUNCT
admet-995	43	1	various	various	ADJ
admet-995	43	2	attempts	attempt	NOUN
admet-995	43	3	have	have	AUX
admet-995	43	4	been	be	AUX
admet-995	43	5	made	make	VERB
admet-995	43	6	to	to	PART
admet-995	43	7	predict	predict	VERB
admet-995	43	8	the	the	DET
admet-995	43	9	herg	herg	PROPN
admet-995	43	10	inhibition	inhibition	NOUN
admet-995	43	11	potential	potential	NOUN
admet-995	43	12	of	of	ADP
admet-995	43	13	drugs	drug	NOUN
admet-995	43	14	in	in	ADP
admet-995	43	15	silico	silico	NOUN
admet-995	43	16	to	to	PART
admet-995	43	17	avoid	avoid	VERB
admet-995	43	18	the	the	DET
admet-995	43	19	synthesis	synthesis	NOUN
admet-995	43	20	of	of	ADP
admet-995	43	21	risky	risky	ADJ
admet-995	43	22	molecules	molecule	NOUN
admet-995	43	23	[	[	X
admet-995	43	24	15	15	NUM
admet-995	43	25	]	]	PUNCT
admet-995	43	26	.	.	PUNCT
admet-995	44	1	when	when	SCONJ
admet-995	44	2	studying	study	VERB
admet-995	44	3	therapeutic	therapeutic	ADJ
admet-995	44	4	areas	area	NOUN
admet-995	44	5	and	and	CCONJ
admet-995	44	6	the	the	DET
admet-995	44	7	safety	safety	NOUN
admet-995	44	8	margins	margin	NOUN
admet-995	44	9	regarding	regard	VERB
admet-995	44	10	the	the	DET
admet-995	44	11	free	free	ADJ
admet-995	44	12	therapeutic	therapeutic	ADJ
admet-995	44	13	plasma	plasma	NOUN
admet-995	44	14	concentration	concentration	NOUN
admet-995	44	15	of	of	ADP
admet-995	44	16	drugs	drug	NOUN
admet-995	44	17	[	[	X
admet-995	44	18	16	16	NUM
admet-995	44	19	]	]	PUNCT
admet-995	44	20	,	,	PUNCT
admet-995	44	21	it	it	PRON
admet-995	44	22	was	be	AUX
admet-995	44	23	found	find	VERB
admet-995	44	24	that	that	SCONJ
admet-995	44	25	a	a	DET
admet-995	44	26	wide	wide	ADJ
admet-995	44	27	variety	variety	NOUN
admet-995	44	28	of	of	ADP
admet-995	44	29	drugs	drug	NOUN
admet-995	44	30	,	,	PUNCT
admet-995	44	31	including	include	VERB
admet-995	44	32	antiarrhythmic	antiarrhythmic	ADJ
admet-995	44	33	,	,	PUNCT
admet-995	44	34	antibacterial	antibacterial	ADJ
admet-995	44	35	,	,	PUNCT
admet-995	44	36	antipsychotic	antipsychotic	ADJ
admet-995	44	37	and	and	CCONJ
admet-995	44	38	pain	pain	NOUN
admet-995	44	39	-	-	PUNCT
admet-995	44	40	killer	killer	NOUN
admet-995	44	41	drugs	drug	NOUN
admet-995	44	42	showed	show	VERB
admet-995	44	43	potential	potential	ADJ
admet-995	44	44	risk	risk	NOUN
admet-995	44	45	.	.	PUNCT
admet-995	45	1	as	as	ADP
admet-995	45	2	toxicity	toxicity	NOUN
admet-995	45	3	,	,	PUNCT
admet-995	45	4	just	just	ADV
admet-995	45	5	like	like	ADP
admet-995	45	6	potency	potency	NOUN
admet-995	45	7	,	,	PUNCT
admet-995	45	8	is	be	AUX
admet-995	45	9	dose	dose	NOUN
admet-995	45	10	-	-	PUNCT
admet-995	45	11	dependent	dependent	ADJ
admet-995	45	12	,	,	PUNCT
admet-995	45	13	it	it	PRON
admet-995	45	14	is	be	AUX
admet-995	45	15	essential	essential	ADJ
admet-995	45	16	to	to	PART
admet-995	45	17	relate	relate	VERB
admet-995	45	18	the	the	DET
admet-995	45	19	herg	herg	PROPN
admet-995	45	20	inhibitory	inhibitory	ADJ
admet-995	45	21	concentration	concentration	NOUN
admet-995	45	22	to	to	ADP
admet-995	45	23	the	the	DET
admet-995	45	24	drugs	drug	NOUN
admet-995	45	25	'	'	PART
admet-995	45	26	free	free	ADJ
admet-995	45	27	therapeutic	therapeutic	ADJ
admet-995	45	28	plasma	plasma	NOUN
admet-995	45	29	concentration	concentration	NOUN
admet-995	45	30	.	.	PUNCT
admet-995	46	1	it	it	PRON
admet-995	46	2	was	be	AUX
admet-995	46	3	found	find	VERB
admet-995	46	4	that	that	SCONJ
admet-995	46	5	a	a	DET
admet-995	46	6	less	less	ADJ
admet-995	46	7	than	than	ADP
admet-995	46	8	30	30	NUM
admet-995	46	9	-	-	ADJ
admet-995	46	10	fold	fold	ADJ
admet-995	46	11	difference	difference	NOUN
admet-995	46	12	between	between	ADP
admet-995	46	13	the	the	DET
admet-995	46	14	therapeutic	therapeutic	ADJ
admet-995	46	15	and	and	CCONJ
admet-995	46	16	inhibitory	inhibitory	ADJ
admet-995	46	17	concentration	concentration	NOUN
admet-995	46	18	indicates	indicate	VERB
admet-995	46	19	a	a	DET
admet-995	46	20	high	high	ADJ
admet-995	46	21	risk	risk	NOUN
admet-995	46	22	.	.	PUNCT
admet-995	47	1	redfern	redfern	PROPN
admet-995	47	2	et	et	PROPN
admet-995	47	3	al	al	PROPN
admet-995	47	4	.	.	PUNCT
admet-995	48	1	[	[	X
admet-995	48	2	16	16	NUM
admet-995	48	3	]	]	PUNCT
admet-995	48	4	also	also	ADV
admet-995	48	5	investigated	investigate	VERB
admet-995	48	6	the	the	DET
admet-995	48	7	relative	relative	ADJ
admet-995	48	8	value	value	NOUN
admet-995	48	9	of	of	ADP
admet-995	48	10	preclinical	preclinical	ADJ
admet-995	48	11	cardiac	cardiac	ADJ
admet-995	48	12	electrophysiology	electrophysiology	NOUN
admet-995	48	13	data	datum	NOUN
admet-995	48	14	(	(	PUNCT
admet-995	48	15	in	in	ADP
admet-995	48	16	vitro	vitro	X
admet-995	48	17	and	and	CCONJ
admet-995	48	18	in	in	ADP
admet-995	48	19	vivo	vivo	NOUN
admet-995	48	20	)	)	PUNCT
admet-995	48	21	for	for	ADP
admet-995	48	22	predicting	predict	VERB
admet-995	48	23	the	the	DET
admet-995	48	24	risk	risk	NOUN
admet-995	48	25	of	of	ADP
admet-995	48	26	tdp	tdp	NOUN
admet-995	48	27	in	in	ADP
admet-995	48	28	drug	drug	NOUN
admet-995	48	29	clinical	clinical	ADJ
admet-995	48	30	use	use	NOUN
admet-995	48	31	.	.	PUNCT
admet-995	49	1	in	in	ADP
admet-995	49	2	vivo	vivo	NOUN
admet-995	49	3	,	,	PUNCT
admet-995	49	4	telemetry	telemetry	NOUN
admet-995	49	5	experiments	experiment	NOUN
admet-995	49	6	in	in	ADP
admet-995	49	7	non	non	NOUN
admet-995	49	8	-	-	NOUN
admet-995	49	9	rodents	rodent	NOUN
admet-995	49	10	(	(	PUNCT
admet-995	49	11	typically	typically	ADV
admet-995	49	12	dogs	dog	NOUN
admet-995	49	13	)	)	PUNCT
admet-995	49	14	are	be	AUX
admet-995	49	15	the	the	DET
admet-995	49	16	ultimate	ultimate	ADJ
admet-995	49	17	preclinical	preclinical	ADJ
admet-995	49	18	test	test	NOUN
admet-995	49	19	for	for	ADP
admet-995	49	20	cardiotoxicity	cardiotoxicity	NOUN
admet-995	49	21	.	.	PUNCT
admet-995	50	1	however	however	ADV
admet-995	50	2	,	,	PUNCT
admet-995	50	3	its	its	PRON
admet-995	50	4	high	high	ADJ
admet-995	50	5	cost	cost	NOUN
admet-995	50	6	severely	severely	ADV
admet-995	50	7	limits	limit	VERB
admet-995	50	8	its	its	PRON
admet-995	50	9	use	use	NOUN
admet-995	50	10	at	at	ADP
admet-995	50	11	the	the	DET
admet-995	50	12	earlier	early	ADJ
admet-995	50	13	discovery	discovery	NOUN
admet-995	50	14	stage	stage	NOUN
admet-995	50	15	[	[	X
admet-995	50	16	17	17	NUM
admet-995	50	17	]	]	PUNCT
admet-995	50	18	.	.	PUNCT
admet-995	51	1	in	in	ADP
admet-995	51	2	vitro	vitro	X
admet-995	51	3	voltage	voltage	NOUN
admet-995	51	4	-	-	PUNCT
admet-995	51	5	clamp	clamp	NOUN
admet-995	51	6	techniques	technique	NOUN
admet-995	51	7	are	be	AUX
admet-995	51	8	widely	widely	ADV
admet-995	51	9	used	use	VERB
admet-995	51	10	to	to	PART
admet-995	51	11	provide	provide	VERB
admet-995	51	12	real	real	ADJ
admet-995	51	13	-	-	PUNCT
admet-995	51	14	time	time	NOUN
admet-995	51	15	mechanistic	mechanistic	ADJ
admet-995	51	16	information	information	NOUN
admet-995	51	17	on	on	ADP
admet-995	51	18	ion	ion	NOUN
admet-995	51	19	channels	channel	NOUN
admet-995	51	20	[	[	X
admet-995	51	21	18	18	NUM
admet-995	51	22	]	]	PUNCT
admet-995	51	23	.	.	PUNCT
admet-995	52	1	the	the	DET
admet-995	52	2	experiments	experiment	NOUN
admet-995	52	3	are	be	AUX
admet-995	52	4	performed	perform	VERB
admet-995	52	5	in	in	ADP
admet-995	52	6	mammalian	mammalian	ADJ
admet-995	52	7	cells	cell	NOUN
admet-995	52	8	transfected	transfecte	VERB
admet-995	52	9	with	with	ADP
admet-995	52	10	the	the	DET
admet-995	52	11	gene	gene	NOUN
admet-995	52	12	for	for	ADP
admet-995	52	13	herg	herg	PROPN
admet-995	52	14	.	.	PUNCT
admet-995	53	1	the	the	DET
admet-995	53	2	overwhelming	overwhelming	ADJ
admet-995	53	3	majority	majority	NOUN
admet-995	53	4	of	of	ADP
admet-995	53	5	predictive	predictive	ADJ
admet-995	53	6	herg	herg	PROPN
admet-995	53	7	models	model	NOUN
admet-995	53	8	have	have	AUX
admet-995	53	9	been	be	AUX
admet-995	53	10	built	build	VERB
admet-995	53	11	using	use	VERB
admet-995	53	12	mammalian	mammalian	ADJ
admet-995	53	13	patch	patch	NOUN
admet-995	53	14	clamp	clamp	NOUN
admet-995	53	15	data	datum	NOUN
admet-995	53	16	.	.	PUNCT
admet-995	54	1	techniques	technique	NOUN
admet-995	54	2	such	such	ADJ
admet-995	54	3	as	as	ADP
admet-995	54	4	fluorescence	fluorescence	NOUN
admet-995	54	5	-	-	PUNCT
admet-995	54	6	based	base	VERB
admet-995	54	7	assays	assay	NOUN
admet-995	54	8	with	with	ADP
admet-995	54	9	cells	cell	NOUN
admet-995	54	10	transfected	transfecte	VERB
admet-995	54	11	with	with	ADP
admet-995	54	12	herg	herg	PROPN
admet-995	54	13	and	and	CCONJ
admet-995	54	14	radioligand	radioligand	PROPN
admet-995	54	15	(	(	PUNCT
admet-995	54	16	typically	typically	ADV
admet-995	54	17	dofetilide	dofetilide	ADJ
admet-995	54	18	or	or	CCONJ
admet-995	54	19	mk-499	mk-499	NOUN
admet-995	54	20	)	)	PUNCT
admet-995	54	21	displacement	displacement	NOUN
admet-995	54	22	assays	assay	NOUN
admet-995	55	1	[	[	X
admet-995	55	2	17	17	NUM
admet-995	55	3	]	]	PUNCT
admet-995	55	4	have	have	AUX
admet-995	55	5	also	also	ADV
admet-995	55	6	been	be	AUX
admet-995	55	7	successfully	successfully	ADV
admet-995	55	8	used	use	VERB
admet-995	55	9	.	.	PUNCT
admet-995	56	1	since	since	SCONJ
admet-995	56	2	the	the	DET
admet-995	56	3	success	success	NOUN
admet-995	56	4	of	of	ADP
admet-995	56	5	any	any	DET
admet-995	56	6	admet	admet	NOUN
admet-995	56	7	&	&	CCONJ
admet-995	56	8	dmpk	dmpk	PROPN
admet-995	56	9	9(3	9(3	NUM
admet-995	56	10	)	)	PUNCT
admet-995	56	11	(	(	PUNCT
admet-995	56	12	2021	2021	NUM
admet-995	56	13	)	)	PUNCT
admet-995	56	14	191	191	NUM
admet-995	56	15	-	-	SYM
admet-995	56	16	207	207	NUM
admet-995	56	17	prediction	prediction	NOUN
admet-995	56	18	of	of	ADP
admet-995	56	19	herg	herg	PROPN
admet-995	56	20	inhibition	inhibition	NOUN
admet-995	56	21	by	by	ADP
admet-995	56	22	biomimetic	biomimetic	ADJ
admet-995	56	23	measurements	measurement	NOUN
admet-995	56	24	doi	doi	NOUN
admet-995	56	25	:	:	PUNCT
admet-995	56	26	http://dx.doi.org/10.5599/admet.995	http://dx.doi.org/10.5599/admet.995	ADJ
admet-995	56	27	193	193	NUM
admet-995	56	28	model	model	NOUN
admet-995	56	29	building	building	NOUN
admet-995	56	30	depends	depend	VERB
admet-995	56	31	on	on	ADP
admet-995	56	32	the	the	DET
admet-995	56	33	quality	quality	NOUN
admet-995	56	34	of	of	ADP
admet-995	56	35	the	the	DET
admet-995	56	36	biological	biological	ADJ
admet-995	56	37	data	datum	NOUN
admet-995	56	38	,	,	PUNCT
admet-995	56	39	it	it	PRON
admet-995	56	40	was	be	AUX
admet-995	56	41	important	important	ADJ
admet-995	56	42	to	to	PART
admet-995	56	43	carefully	carefully	ADV
admet-995	56	44	select	select	VERB
admet-995	56	45	reliable	reliable	ADJ
admet-995	56	46	and	and	CCONJ
admet-995	56	47	informative	informative	ADJ
admet-995	56	48	cardiotoxicity	cardiotoxicity	NOUN
admet-995	56	49	data	datum	NOUN
admet-995	56	50	for	for	ADP
admet-995	56	51	a	a	DET
admet-995	56	52	wide	wide	ADJ
admet-995	56	53	variety	variety	NOUN
admet-995	56	54	of	of	ADP
admet-995	56	55	drugs	drug	NOUN
admet-995	56	56	in	in	ADP
admet-995	56	57	order	order	NOUN
admet-995	56	58	to	to	PART
admet-995	56	59	develop	develop	VERB
admet-995	56	60	a	a	DET
admet-995	56	61	continuous	continuous	ADJ
admet-995	56	62	model	model	NOUN
admet-995	56	63	.	.	PUNCT
admet-995	57	1	as	as	ADP
admet-995	57	2	the	the	DET
admet-995	57	3	determination	determination	NOUN
admet-995	57	4	of	of	ADP
admet-995	57	5	the	the	DET
admet-995	57	6	half	half	ADJ
admet-995	57	7	-	-	PUNCT
admet-995	57	8	maximal	maximal	ADJ
admet-995	57	9	inhibitory	inhibitory	ADJ
admet-995	57	10	concentration	concentration	NOUN
admet-995	57	11	(	(	PUNCT
admet-995	57	12	ic50	ic50	PROPN
admet-995	57	13	)	)	PUNCT
admet-995	57	14	value	value	NOUN
admet-995	57	15	requires	require	VERB
admet-995	57	16	measurements	measurement	NOUN
admet-995	57	17	of	of	ADP
admet-995	57	18	inhibitory	inhibitory	ADJ
admet-995	57	19	activities	activity	NOUN
admet-995	57	20	at	at	ADP
admet-995	57	21	multiple	multiple	ADJ
admet-995	57	22	concentrations	concentration	NOUN
admet-995	57	23	,	,	PUNCT
admet-995	57	24	the	the	DET
admet-995	57	25	ic50	ic50	PROPN
admet-995	57	26	information	information	NOUN
admet-995	57	27	was	be	AUX
admet-995	57	28	considered	consider	VERB
admet-995	57	29	more	more	ADV
admet-995	57	30	reliable	reliable	ADJ
admet-995	57	31	,	,	PUNCT
admet-995	57	32	and	and	CCONJ
admet-995	57	33	was	be	AUX
admet-995	57	34	selected	select	VERB
admet-995	57	35	over	over	ADP
admet-995	57	36	the	the	DET
admet-995	57	37	inhibition	inhibition	NOUN
admet-995	57	38	type	type	NOUN
admet-995	57	39	entries	entry	NOUN
admet-995	57	40	for	for	ADP
admet-995	57	41	positive	positive	ADJ
admet-995	57	42	/	/	SYM
admet-995	57	43	negative	negative	ADJ
admet-995	57	44	classification	classification	NOUN
admet-995	57	45	.	.	PUNCT
admet-995	58	1	therefore	therefore	ADV
admet-995	58	2	,	,	PUNCT
admet-995	58	3	ic50	ic50	PROPN
admet-995	58	4	of	of	ADP
admet-995	58	5	drugs	drug	NOUN
admet-995	58	6	and	and	CCONJ
admet-995	58	7	their	their	PRON
admet-995	58	8	log	log	NOUN
admet-995	58	9	unit	unit	NOUN
admet-995	58	10	values	value	NOUN
admet-995	58	11	(	(	PUNCT
admet-995	58	12	pic50	pic50	NOUN
admet-995	58	13	)	)	PUNCT
admet-995	58	14	in	in	ADP
admet-995	58	15	response	response	NOUN
admet-995	58	16	to	to	ADP
admet-995	58	17	herg	herg	PROPN
admet-995	58	18	were	be	AUX
admet-995	58	19	collected	collect	VERB
admet-995	58	20	from	from	ADP
admet-995	58	21	the	the	DET
admet-995	58	22	literature	literature	NOUN
admet-995	58	23	.	.	PUNCT
admet-995	59	1	certain	certain	ADJ
admet-995	59	2	physicochemical	physicochemical	ADJ
admet-995	59	3	properties	property	NOUN
admet-995	59	4	of	of	ADP
admet-995	59	5	molecules	molecule	NOUN
admet-995	59	6	have	have	AUX
admet-995	59	7	been	be	AUX
admet-995	59	8	recognized	recognize	VERB
admet-995	59	9	as	as	ADP
admet-995	59	10	early	early	ADJ
admet-995	59	11	indicators	indicator	NOUN
admet-995	59	12	of	of	ADP
admet-995	59	13	potential	potential	ADJ
admet-995	59	14	problems	problem	NOUN
admet-995	59	15	with	with	ADP
admet-995	59	16	early	early	ADJ
admet-995	59	17	drug	drug	NOUN
admet-995	59	18	discovery	discovery	NOUN
admet-995	59	19	compounds	compound	VERB
admet-995	59	20	[	[	X
admet-995	59	21	19	19	NUM
admet-995	59	22	]	]	PUNCT
admet-995	59	23	.	.	PUNCT
admet-995	60	1	besides	besides	SCONJ
admet-995	60	2	lipophilicity	lipophilicity	NOUN
admet-995	60	3	[	[	X
admet-995	60	4	20	20	NUM
admet-995	60	5	]	]	PUNCT
admet-995	60	6	,	,	PUNCT
admet-995	60	7	solubility	solubility	NOUN
admet-995	60	8	[	[	X
admet-995	60	9	21	21	NUM
admet-995	60	10	]	]	PUNCT
admet-995	60	11	and	and	CCONJ
admet-995	60	12	permeability	permeability	NOUN
admet-995	60	13	,	,	PUNCT
admet-995	60	14	biomimetic	biomimetic	ADJ
admet-995	60	15	properties	property	NOUN
admet-995	60	16	such	such	ADJ
admet-995	60	17	as	as	ADP
admet-995	60	18	protein	protein	NOUN
admet-995	60	19	[	[	X
admet-995	60	20	22	22	NUM
admet-995	60	21	]	]	PUNCT
admet-995	60	22	and	and	CCONJ
admet-995	60	23	phospholipid	phospholipid	NOUN
admet-995	60	24	binding	bind	VERB
admet-995	60	25	[	[	X
admet-995	60	26	23	23	NUM
admet-995	60	27	]	]	PUNCT
admet-995	60	28	can	can	AUX
admet-995	60	29	be	be	AUX
admet-995	60	30	measured	measure	VERB
admet-995	60	31	at	at	ADP
admet-995	60	32	the	the	DET
admet-995	60	33	early	early	ADJ
admet-995	60	34	stages	stage	NOUN
admet-995	60	35	of	of	ADP
admet-995	60	36	the	the	DET
admet-995	60	37	drug	drug	NOUN
admet-995	60	38	discovery	discovery	NOUN
admet-995	60	39	process	process	NOUN
admet-995	60	40	[	[	X
admet-995	60	41	24	24	NUM
admet-995	60	42	]	]	PUNCT
admet-995	60	43	.	.	PUNCT
admet-995	61	1	the	the	DET
admet-995	61	2	chromatographic	chromatographic	ADJ
admet-995	61	3	technique	technique	NOUN
admet-995	61	4	provides	provide	VERB
admet-995	61	5	an	an	DET
admet-995	61	6	automated	automate	VERB
admet-995	61	7	,	,	PUNCT
admet-995	61	8	high	high	ADJ
admet-995	61	9	throughput	throughput	NOUN
admet-995	61	10	and	and	CCONJ
admet-995	61	11	reliable	reliable	ADJ
admet-995	61	12	measurement	measurement	NOUN
admet-995	61	13	of	of	ADP
admet-995	61	14	important	important	ADJ
admet-995	61	15	properties	property	NOUN
admet-995	61	16	of	of	ADP
admet-995	61	17	the	the	DET
admet-995	61	18	drug	drug	NOUN
admet-995	61	19	discovery	discovery	NOUN
admet-995	61	20	compounds	compound	VERB
admet-995	61	21	[	[	X
admet-995	61	22	25	25	NUM
admet-995	61	23	]	]	PUNCT
admet-995	61	24	that	that	PRON
admet-995	61	25	can	can	AUX
admet-995	61	26	be	be	AUX
admet-995	61	27	used	use	VERB
admet-995	61	28	to	to	PART
admet-995	61	29	estimate	estimate	VERB
admet-995	61	30	later	late	ADJ
admet-995	61	31	stage	stage	NOUN
admet-995	61	32	in	in	ADP
admet-995	61	33	vivo	vivo	ADJ
admet-995	61	34	properties	property	NOUN
admet-995	61	35	of	of	ADP
admet-995	61	36	compounds	compound	NOUN
admet-995	61	37	such	such	ADJ
admet-995	61	38	as	as	ADP
admet-995	61	39	the	the	DET
admet-995	61	40	volume	volume	NOUN
admet-995	61	41	of	of	ADP
admet-995	61	42	distribution	distribution	NOUN
admet-995	61	43	,	,	PUNCT
admet-995	61	44	the	the	DET
admet-995	61	45	unbound	unbound	NOUN
admet-995	61	46	volume	volume	NOUN
admet-995	61	47	of	of	ADP
admet-995	61	48	distribution	distribution	NOUN
admet-995	61	49	[	[	X
admet-995	61	50	26	26	NUM
admet-995	61	51	]	]	PUNCT
admet-995	61	52	and	and	CCONJ
admet-995	61	53	the	the	DET
admet-995	61	54	drug	drug	NOUN
admet-995	61	55	efficiency	efficiency	NOUN
admet-995	61	56	[	[	X
admet-995	61	57	27	27	NUM
admet-995	61	58	]	]	PUNCT
admet-995	61	59	.	.	PUNCT
admet-995	62	1	measurements	measurement	NOUN
admet-995	62	2	can	can	AUX
admet-995	62	3	also	also	ADV
admet-995	62	4	estimate	estimate	VERB
admet-995	62	5	cell	cell	NOUN
admet-995	62	6	membrane	membrane	NOUN
admet-995	62	7	partition	partition	NOUN
admet-995	62	8	and	and	CCONJ
admet-995	62	9	skin	skin	NOUN
admet-995	62	10	penetration	penetration	NOUN
admet-995	62	11	of	of	ADP
admet-995	62	12	compounds	compound	NOUN
admet-995	62	13	based	base	VERB
admet-995	62	14	on	on	ADP
admet-995	62	15	chromatographic	chromatographic	ADJ
admet-995	62	16	principles	principle	NOUN
admet-995	62	17	[	[	X
admet-995	62	18	28,29	28,29	NUM
admet-995	62	19	]	]	X
admet-995	62	20	.	.	PUNCT
admet-995	63	1	various	various	ADJ
admet-995	63	2	toxicity	toxicity	NOUN
admet-995	63	3	indicators	indicator	NOUN
admet-995	63	4	have	have	AUX
admet-995	63	5	already	already	ADV
admet-995	63	6	been	be	AUX
admet-995	63	7	related	relate	VERB
admet-995	63	8	to	to	ADP
admet-995	63	9	a	a	DET
admet-995	63	10	compound	compound	NOUN
admet-995	63	11	’s	’s	PART
admet-995	63	12	physicochemical	physicochemical	ADJ
admet-995	63	13	properties	property	NOUN
admet-995	63	14	,	,	PUNCT
admet-995	63	15	including	include	VERB
admet-995	63	16	herg	herg	PROPN
admet-995	63	17	inhibition	inhibition	NOUN
admet-995	63	18	and	and	CCONJ
admet-995	63	19	hepatotoxicity	hepatotoxicity	NOUN
admet-995	63	20	[	[	X
admet-995	63	21	30	30	NUM
admet-995	63	22	]	]	PUNCT
admet-995	63	23	.	.	PUNCT
admet-995	64	1	the	the	DET
admet-995	64	2	toxicity	toxicity	NOUN
admet-995	64	3	potential	potential	NOUN
admet-995	64	4	of	of	ADP
admet-995	64	5	compounds	compound	NOUN
admet-995	64	6	has	have	AUX
admet-995	64	7	been	be	AUX
admet-995	64	8	studied	study	VERB
admet-995	64	9	using	use	VERB
admet-995	64	10	the	the	DET
admet-995	64	11	immobilised	immobilised	ADJ
admet-995	64	12	artificial	artificial	ADJ
admet-995	64	13	membrane	membrane	NOUN
admet-995	64	14	(	(	PUNCT
admet-995	64	15	iam	iam	PROPN
admet-995	64	16	)	)	PUNCT
admet-995	64	17	chromatography	chromatography	NOUN
admet-995	65	1	[	[	X
admet-995	65	2	31	31	NUM
admet-995	65	3	]	]	PUNCT
admet-995	65	4	.	.	PUNCT
admet-995	66	1	in	in	ADP
admet-995	66	2	this	this	DET
admet-995	66	3	work	work	NOUN
admet-995	66	4	,	,	PUNCT
admet-995	66	5	several	several	ADJ
admet-995	66	6	chromatography	chromatography	NOUN
admet-995	66	7	-	-	PUNCT
admet-995	66	8	based	base	VERB
admet-995	66	9	techniques	technique	NOUN
admet-995	66	10	were	be	AUX
admet-995	66	11	investigated	investigate	VERB
admet-995	66	12	to	to	PART
admet-995	66	13	search	search	VERB
admet-995	66	14	for	for	ADP
admet-995	66	15	the	the	DET
admet-995	66	16	properties	property	NOUN
admet-995	66	17	of	of	ADP
admet-995	66	18	the	the	DET
admet-995	66	19	compounds	compound	NOUN
admet-995	66	20	that	that	PRON
admet-995	66	21	could	could	AUX
admet-995	66	22	be	be	AUX
admet-995	66	23	used	use	VERB
admet-995	66	24	to	to	PART
admet-995	66	25	predict	predict	VERB
admet-995	66	26	their	their	PRON
admet-995	66	27	toxicity	toxicity	NOUN
admet-995	66	28	,	,	PUNCT
admet-995	66	29	with	with	ADP
admet-995	66	30	special	special	ADJ
admet-995	66	31	emphasis	emphasis	NOUN
admet-995	66	32	on	on	ADP
admet-995	66	33	cardiotoxicity	cardiotoxicity	NOUN
admet-995	66	34	.	.	PUNCT
admet-995	67	1	in	in	ADP
admet-995	67	2	this	this	DET
admet-995	67	3	study	study	NOUN
admet-995	67	4	,	,	PUNCT
admet-995	67	5	herg	herg	PROPN
admet-995	67	6	pic50	pic50	PROPN
admet-995	67	7	data	datum	NOUN
admet-995	67	8	from	from	ADP
admet-995	67	9	a	a	DET
admet-995	67	10	set	set	NOUN
admet-995	67	11	of	of	ADP
admet-995	67	12	90	90	NUM
admet-995	67	13	diverse	diverse	ADJ
admet-995	67	14	marketed	market	VERB
admet-995	67	15	drugs	drug	NOUN
admet-995	67	16	from	from	ADP
admet-995	67	17	a	a	DET
admet-995	67	18	wide	wide	ADJ
admet-995	67	19	range	range	NOUN
admet-995	67	20	of	of	ADP
admet-995	67	21	therapeutic	therapeutic	ADJ
admet-995	67	22	areas	area	NOUN
admet-995	67	23	and	and	CCONJ
admet-995	67	24	with	with	ADP
admet-995	67	25	different	different	ADJ
admet-995	67	26	physicochemical	physicochemical	ADJ
admet-995	67	27	properties	property	NOUN
admet-995	67	28	were	be	AUX
admet-995	67	29	correlated	correlate	VERB
admet-995	67	30	with	with	ADP
admet-995	67	31	their	their	PRON
admet-995	67	32	measured	measure	VERB
admet-995	67	33	biomimetic	biomimetic	ADJ
admet-995	67	34	properties	property	NOUN
admet-995	67	35	.	.	PUNCT
admet-995	68	1	the	the	DET
admet-995	68	2	measurement	measurement	NOUN
admet-995	68	3	of	of	ADP
admet-995	68	4	the	the	DET
admet-995	68	5	biomimetic	biomimetic	ADJ
admet-995	68	6	properties	property	NOUN
admet-995	68	7	of	of	ADP
admet-995	68	8	the	the	DET
admet-995	68	9	available	available	ADJ
admet-995	68	10	drugs	drug	NOUN
admet-995	68	11	was	be	AUX
admet-995	68	12	conducted	conduct	VERB
admet-995	68	13	in	in	ADP
admet-995	68	14	our	our	PRON
admet-995	68	15	laboratories	laboratory	NOUN
admet-995	68	16	.	.	PUNCT
admet-995	69	1	generic	generic	ADJ
admet-995	69	2	gradient	gradient	NOUN
admet-995	69	3	hplc	hplc	NOUN
admet-995	69	4	methods	method	NOUN
admet-995	69	5	were	be	AUX
admet-995	69	6	used	use	VERB
admet-995	69	7	to	to	PART
admet-995	69	8	determine	determine	VERB
admet-995	69	9	the	the	DET
admet-995	69	10	chromatographic	chromatographic	ADJ
admet-995	69	11	hydrophobicity	hydrophobicity	NOUN
admet-995	69	12	index	index	NOUN
admet-995	69	13	(	(	PUNCT
admet-995	69	14	chi	chi	NOUN
admet-995	69	15	)	)	PUNCT
admet-995	70	1	[	[	X
admet-995	70	2	32,33	32,33	NUM
admet-995	70	3	]	]	PUNCT
admet-995	70	4	using	use	VERB
admet-995	70	5	mobile	mobile	ADJ
admet-995	70	6	phases	phase	NOUN
admet-995	70	7	at	at	ADP
admet-995	70	8	three	three	NUM
admet-995	70	9	different	different	ADJ
admet-995	70	10	ph	ph	ADJ
admet-995	70	11	values	value	NOUN
admet-995	70	12	.	.	PUNCT
admet-995	71	1	the	the	DET
admet-995	71	2	protein	protein	NOUN
admet-995	71	3	binding	bind	VERB
admet-995	71	4	of	of	ADP
admet-995	71	5	the	the	DET
admet-995	71	6	compounds	compound	NOUN
admet-995	71	7	was	be	AUX
admet-995	71	8	measured	measure	VERB
admet-995	71	9	using	use	VERB
admet-995	71	10	immobilised	immobilised	ADJ
admet-995	71	11	human	human	ADJ
admet-995	71	12	serum	serum	NOUN
admet-995	71	13	albumin	albumin	PROPN
admet-995	71	14	(	(	PUNCT
admet-995	71	15	hsa	hsa	PROPN
admet-995	71	16	)	)	PUNCT
admet-995	72	1	[	[	X
admet-995	72	2	22	22	NUM
admet-995	72	3	]	]	PUNCT
admet-995	72	4	,	,	PUNCT
admet-995	72	5	and	and	CCONJ
admet-995	72	6	alpha-1	alpha-1	NOUN
admet-995	72	7	-	-	PUNCT
admet-995	72	8	acid	acid	NOUN
admet-995	72	9	-	-	PUNCT
admet-995	72	10	glycoprotein	glycoprotein	NOUN
admet-995	72	11	(	(	PUNCT
admet-995	72	12	agp	agp	NOUN
admet-995	72	13	)	)	PUNCT
admet-995	72	14	stationary	stationary	ADJ
admet-995	72	15	phases	phase	NOUN
admet-995	72	16	[	[	X
admet-995	72	17	34	34	NUM
admet-995	72	18	]	]	PUNCT
admet-995	72	19	.	.	PUNCT
admet-995	73	1	the	the	DET
admet-995	73	2	phospholipid	phospholipid	NOUN
admet-995	73	3	-	-	PUNCT
admet-995	73	4	binding	bind	VERB
admet-995	73	5	was	be	AUX
admet-995	73	6	measured	measure	VERB
admet-995	73	7	using	use	VERB
admet-995	73	8	the	the	DET
admet-995	73	9	immobilised	immobilised	ADJ
admet-995	73	10	artificial	artificial	ADJ
admet-995	73	11	membrane	membrane	NOUN
admet-995	73	12	(	(	PUNCT
admet-995	73	13	iam	iam	PROPN
admet-995	73	14	)	)	PUNCT
admet-995	73	15	stationary	stationary	ADJ
admet-995	73	16	phase	phase	NOUN
admet-995	73	17	[	[	X
admet-995	73	18	23	23	NUM
admet-995	73	19	]	]	PUNCT
admet-995	73	20	.	.	PUNCT
admet-995	74	1	the	the	DET
admet-995	74	2	aim	aim	NOUN
admet-995	74	3	was	be	AUX
admet-995	74	4	to	to	PART
admet-995	74	5	establish	establish	VERB
admet-995	74	6	relationships	relationship	NOUN
admet-995	74	7	between	between	ADP
admet-995	74	8	the	the	DET
admet-995	74	9	cardiotoxicity	cardiotoxicity	NOUN
admet-995	74	10	potential	potential	NOUN
admet-995	74	11	and	and	CCONJ
admet-995	74	12	the	the	DET
admet-995	74	13	biomimetic	biomimetic	ADJ
admet-995	74	14	binding	bind	VERB
admet-995	74	15	properties	property	NOUN
admet-995	74	16	of	of	ADP
admet-995	74	17	the	the	DET
admet-995	74	18	drugs	drug	NOUN
admet-995	74	19	and	and	CCONJ
admet-995	74	20	to	to	PART
admet-995	74	21	evaluate	evaluate	VERB
admet-995	74	22	their	their	PRON
admet-995	74	23	predictive	predictive	ADJ
admet-995	74	24	performance	performance	NOUN
admet-995	74	25	.	.	PUNCT
admet-995	75	1	experimental	experimental	ADJ
admet-995	75	2	the	the	DET
admet-995	75	3	drugs	drug	NOUN
admet-995	75	4	were	be	AUX
admet-995	75	5	obtained	obtain	VERB
admet-995	75	6	from	from	ADP
admet-995	75	7	sigma	sigma	PROPN
admet-995	75	8	-	-	PUNCT
admet-995	75	9	aldrich	aldrich	PROPN
admet-995	75	10	(	(	PUNCT
admet-995	75	11	merck	merck	PROPN
admet-995	75	12	)	)	PUNCT
admet-995	75	13	and	and	CCONJ
admet-995	75	14	dissolved	dissolve	VERB
admet-995	75	15	in	in	ADP
admet-995	75	16	dimethylsulfoxide	dimethylsulfoxide	ADJ
admet-995	75	17	(	(	PUNCT
admet-995	75	18	dmso	dmso	NOUN
admet-995	75	19	)	)	PUNCT
admet-995	75	20	at	at	ADP
admet-995	75	21	10	10	NUM
admet-995	75	22	mm	mm	NOUN
admet-995	75	23	concentration	concentration	NOUN
admet-995	75	24	.	.	PUNCT
admet-995	76	1	the	the	DET
admet-995	76	2	10	10	NUM
admet-995	76	3	µl	µl	ADP
admet-995	76	4	stock	stock	NOUN
admet-995	76	5	solutions	solution	NOUN
admet-995	76	6	were	be	AUX
admet-995	76	7	diluted	dilute	VERB
admet-995	76	8	down	down	ADP
admet-995	76	9	to	to	ADP
admet-995	76	10	100	100	NUM
admet-995	76	11	µl	µl	ADP
admet-995	76	12	before	before	ADP
admet-995	76	13	injecting	inject	VERB
admet-995	76	14	them	they	PRON
admet-995	76	15	onto	onto	ADP
admet-995	76	16	an	an	DET
admet-995	76	17	agilent	agilent	PROPN
admet-995	76	18	1100	1100	NUM
admet-995	76	19	hplc	hplc	NOUN
admet-995	76	20	system	system	NOUN
admet-995	76	21	.	.	PUNCT
admet-995	77	1	chi	chi	PROPN
admet-995	77	2	lipophilicity	lipophilicity	PROPN
admet-995	77	3	measurements	measurement	VERB
admet-995	77	4	the	the	DET
admet-995	77	5	chromatographic	chromatographic	ADJ
admet-995	77	6	hydrophobicity	hydrophobicity	NOUN
admet-995	77	7	index	index	NOUN
admet-995	77	8	(	(	PUNCT
admet-995	77	9	chi	chi	PROPN
admet-995	77	10	)	)	PUNCT
admet-995	77	11	was	be	AUX
admet-995	77	12	measured	measure	VERB
admet-995	77	13	using	use	VERB
admet-995	77	14	the	the	DET
admet-995	77	15	compounds	compound	NOUN
admet-995	77	16	'	'	PART
admet-995	77	17	calibrated	calibrate	VERB
admet-995	77	18	gradient	gradient	ADJ
admet-995	77	19	retention	retention	NOUN
admet-995	77	20	times	time	NOUN
admet-995	77	21	obtained	obtain	VERB
admet-995	77	22	from	from	ADP
admet-995	77	23	an	an	DET
admet-995	77	24	agilent	agilent	PROPN
admet-995	77	25	1100	1100	NUM
admet-995	77	26	hplc	hplc	PROPN
admet-995	77	27	fitted	fit	VERB
admet-995	77	28	with	with	ADP
admet-995	77	29	a	a	DET
admet-995	77	30	gemini	gemini	ADJ
admet-995	77	31	nx	nx	PROPN
admet-995	77	32	-	-	PUNCT
admet-995	77	33	c-18	c-18	PROPN
admet-995	77	34	column	column	NOUN
admet-995	77	35	(	(	PUNCT
admet-995	77	36	phenomenex	phenomenex	ADV
admet-995	77	37	ltd	ltd	PROPN
admet-995	77	38	macclesfield	macclesfield	PROPN
admet-995	77	39	,	,	PUNCT
admet-995	77	40	uk	uk	PROPN
admet-995	77	41	)	)	PUNCT
admet-995	77	42	with	with	ADP
admet-995	77	43	dimensions	dimension	NOUN
admet-995	77	44	of	of	ADP
admet-995	77	45	50	50	NUM
admet-995	77	46	x	x	SYM
admet-995	77	47	3	3	NUM
admet-995	77	48	mm	mm	NOUN
admet-995	77	49	and	and	CCONJ
admet-995	77	50	5	5	NUM
admet-995	77	51	µm	µm	ADP
admet-995	77	52	particle	particle	NOUN
admet-995	77	53	size	size	NOUN
admet-995	77	54	.	.	PUNCT
admet-995	78	1	the	the	DET
admet-995	78	2	mobile	mobile	ADJ
admet-995	78	3	phase	phase	NOUN
admet-995	78	4	a	a	PRON
admet-995	78	5	was	be	AUX
admet-995	78	6	either	either	CCONJ
admet-995	78	7	0.01	0.01	NUM
admet-995	78	8	m	m	NOUN
admet-995	78	9	formic	formic	ADJ
admet-995	78	10	acid	acid	NOUN
admet-995	78	11	(	(	PUNCT
admet-995	78	12	ph	ph	NOUN
admet-995	78	13	2.6	2.6	NUM
admet-995	78	14	)	)	PUNCT
admet-995	78	15	,	,	PUNCT
admet-995	78	16	a	a	DET
admet-995	78	17	50	50	NUM
admet-995	78	18	mm	mm	NOUN
admet-995	78	19	ammonium	ammonium	NOUN
admet-995	78	20	acetate	acetate	NOUN
admet-995	78	21	buffer	buffer	NOUN
admet-995	78	22	with	with	ADP
admet-995	78	23	an	an	DET
admet-995	78	24	adjusted	adjust	VERB
admet-995	78	25	ph	ph	NOUN
admet-995	78	26	of	of	ADP
admet-995	78	27	7.4	7.4	NUM
admet-995	78	28	or	or	CCONJ
admet-995	78	29	a	a	DET
admet-995	78	30	50	50	NUM
admet-995	78	31	mm	mm	NOUN
admet-995	78	32	ammonium	ammonium	NOUN
admet-995	78	33	acetate	acetate	NOUN
admet-995	78	34	buffer	buffer	NOUN
admet-995	78	35	with	with	ADP
admet-995	78	36	an	an	DET
admet-995	78	37	adjusted	adjust	VERB
admet-995	78	38	ph	ph	NOUN
admet-995	78	39	of	of	ADP
admet-995	78	40	10.5	10.5	NUM
admet-995	78	41	.	.	PUNCT
admet-995	79	1	the	the	DET
admet-995	79	2	mobile	mobile	ADJ
admet-995	79	3	phase	phase	NOUN
admet-995	79	4	b	b	NOUN
admet-995	79	5	was	be	AUX
admet-995	79	6	100	100	NUM
admet-995	79	7	%	%	NOUN
admet-995	79	8	acetonitrile	acetonitrile	NOUN
admet-995	79	9	.	.	PUNCT
admet-995	80	1	the	the	DET
admet-995	80	2	flow	flow	NOUN
admet-995	80	3	rate	rate	NOUN
admet-995	80	4	was	be	AUX
admet-995	80	5	1.0	1.0	NUM
admet-995	80	6	ml	ml	NOUN
admet-995	80	7	/	/	SYM
admet-995	80	8	min	min	NOUN
admet-995	80	9	,	,	PUNCT
admet-995	80	10	with	with	ADP
admet-995	80	11	starting	start	VERB
admet-995	80	12	mobile	mobile	ADJ
admet-995	80	13	phases	phase	NOUN
admet-995	80	14	of	of	ADP
admet-995	80	15	0.01	0.01	NUM
admet-995	80	16	m	m	NOUN
admet-995	80	17	formic	formic	ADJ
admet-995	80	18	acid	acid	NOUN
admet-995	80	19	(	(	PUNCT
admet-995	80	20	ph	ph	NOUN
admet-995	80	21	2.6	2.6	NUM
admet-995	80	22	)	)	PUNCT
admet-995	80	23	,	,	PUNCT
admet-995	80	24	50	50	NUM
admet-995	80	25	mm	mm	NOUN
admet-995	80	26	ammonium	ammonium	NOUN
admet-995	80	27	acetate	acetate	NOUN
admet-995	80	28	adjusted	adjust	VERB
admet-995	80	29	to	to	ADP
admet-995	80	30	ph	ph	PROPN
admet-995	80	31	7.4	7.4	NUM
admet-995	80	32	,	,	PUNCT
admet-995	80	33	and	and	CCONJ
admet-995	80	34	50	50	NUM
admet-995	80	35	mm	mm	NOUN
admet-995	80	36	ammonium	ammonium	NOUN
admet-995	80	37	acetate	acetate	NOUN
admet-995	80	38	adjusted	adjust	VERB
admet-995	80	39	to	to	ADP
admet-995	80	40	ph	ph	PROPN
admet-995	80	41	10.5	10.5	NUM
admet-995	80	42	to	to	PART
admet-995	80	43	determine	determine	VERB
admet-995	80	44	the	the	DET
admet-995	80	45	lipophilicity	lipophilicity	NOUN
admet-995	80	46	of	of	ADP
admet-995	80	47	the	the	DET
admet-995	80	48	compounds	compound	NOUN
admet-995	80	49	at	at	ADP
admet-995	80	50	acidic	acidic	ADJ
admet-995	80	51	,	,	PUNCT
admet-995	80	52	neutral	neutral	ADJ
admet-995	80	53	and	and	CCONJ
admet-995	80	54	alkaline	alkaline	NOUN
admet-995	80	55	phs	ph	NOUN
admet-995	80	56	,	,	PUNCT
admet-995	80	57	respectively	respectively	ADV
admet-995	80	58	.	.	PUNCT
admet-995	81	1	an	an	DET
admet-995	81	2	http://dx.doi.org/10.5599/admet.0000	http://dx.doi.org/10.5599/admet.0000	X
admet-995	81	3	stergiopoulos	stergiopoulos	X
admet-995	81	4	,	,	PUNCT
admet-995	81	5	tsopelas	tsopela	NOUN
admet-995	81	6	and	and	CCONJ
admet-995	81	7	valko	valko	PROPN
admet-995	81	8	admet	admet	PROPN
admet-995	81	9	&	&	CCONJ
admet-995	81	10	dmpk	dmpk	PROPN
admet-995	81	11	9(3	9(3	NUM
admet-995	81	12	)	)	PUNCT
admet-995	81	13	(	(	PUNCT
admet-995	81	14	2021	2021	NUM
admet-995	81	15	)	)	PUNCT
admet-995	81	16	191	191	NUM
admet-995	81	17	-	-	SYM
admet-995	81	18	207	207	NUM
admet-995	81	19	194	194	NUM
admet-995	81	20	acetonitrile	acetonitrile	ADJ
admet-995	81	21	linear	linear	PROPN
admet-995	81	22	gradient	gradient	NOUN
admet-995	81	23	was	be	AUX
admet-995	81	24	used	use	VERB
admet-995	81	25	from	from	ADP
admet-995	81	26	0	0	NUM
admet-995	81	27	to	to	PART
admet-995	81	28	100	100	NUM
admet-995	81	29	%	%	NOUN
admet-995	81	30	.	.	PUNCT
admet-995	82	1	the	the	DET
admet-995	82	2	acetonitrile	acetonitrile	ADJ
admet-995	82	3	concentration	concentration	NOUN
admet-995	82	4	reached	reach	VERB
admet-995	82	5	100	100	NUM
admet-995	82	6	%	%	NOUN
admet-995	82	7	in	in	ADP
admet-995	82	8	3.5	3.5	NUM
admet-995	82	9	min	min	NOUN
admet-995	82	10	.	.	PUNCT
admet-995	83	1	the	the	DET
admet-995	83	2	100	100	NUM
admet-995	83	3	%	%	NOUN
admet-995	83	4	acetonitrile	acetonitrile	ADJ
admet-995	83	5	mobile	mobile	ADJ
admet-995	83	6	phase	phase	NOUN
admet-995	83	7	was	be	AUX
admet-995	83	8	maintained	maintain	VERB
admet-995	83	9	for	for	ADP
admet-995	83	10	an	an	DET
admet-995	83	11	additional	additional	ADJ
admet-995	83	12	1	1	NUM
admet-995	83	13	min	min	NOUN
admet-995	83	14	before	before	SCONJ
admet-995	83	15	it	it	PRON
admet-995	83	16	was	be	AUX
admet-995	83	17	returned	return	VERB
admet-995	83	18	to	to	ADP
admet-995	83	19	0	0	NUM
admet-995	83	20	%	%	NOUN
admet-995	83	21	at	at	ADP
admet-995	83	22	4.7	4.7	NUM
admet-995	83	23	min	min	NOUN
admet-995	83	24	.	.	PUNCT
admet-995	84	1	the	the	DET
admet-995	84	2	gradient	gradient	NOUN
admet-995	84	3	run	run	NOUN
admet-995	84	4	cycle	cycle	NOUN
admet-995	84	5	time	time	NOUN
admet-995	84	6	was	be	AUX
admet-995	84	7	6	6	NUM
admet-995	84	8	min	min	NOUN
admet-995	84	9	,	,	PUNCT
admet-995	84	10	with	with	ADP
admet-995	84	11	an	an	DET
admet-995	84	12	additional	additional	ADJ
admet-995	84	13	equilibration	equilibration	NOUN
admet-995	84	14	time	time	NOUN
admet-995	84	15	of	of	ADP
admet-995	84	16	1	1	NUM
admet-995	84	17	min	min	NOUN
admet-995	84	18	before	before	ADP
admet-995	84	19	the	the	DET
admet-995	84	20	next	next	ADJ
admet-995	84	21	injection	injection	NOUN
admet-995	84	22	.	.	PUNCT
admet-995	85	1	the	the	DET
admet-995	85	2	standard	standard	ADJ
admet-995	85	3	deviation	deviation	NOUN
admet-995	85	4	in	in	ADP
admet-995	85	5	the	the	DET
admet-995	85	6	retention	retention	NOUN
admet-995	85	7	time	time	NOUN
admet-995	85	8	measurements	measurement	NOUN
admet-995	85	9	is	be	AUX
admet-995	85	10	±0.005	±0.005	VERB
admet-995	85	11	min	min	NOUN
admet-995	85	12	from	from	ADP
admet-995	85	13	repeated	repeat	VERB
admet-995	85	14	injections	injection	NOUN
admet-995	85	15	.	.	PUNCT
admet-995	86	1	the	the	DET
admet-995	86	2	retention	retention	NOUN
admet-995	86	3	time	time	NOUN
admet-995	86	4	values	value	NOUN
admet-995	86	5	for	for	ADP
admet-995	86	6	a	a	DET
admet-995	86	7	standard	standard	ADJ
admet-995	86	8	set	set	NOUN
admet-995	86	9	of	of	ADP
admet-995	86	10	compounds	compound	NOUN
admet-995	86	11	listed	list	VERB
admet-995	86	12	in	in	ADP
admet-995	86	13	table1	table1	PROPN
admet-995	86	14	were	be	AUX
admet-995	86	15	used	use	VERB
admet-995	86	16	to	to	PART
admet-995	86	17	convert	convert	VERB
admet-995	86	18	the	the	DET
admet-995	86	19	drug	drug	NOUN
admet-995	86	20	retention	retention	NOUN
admet-995	86	21	times	time	NOUN
admet-995	86	22	to	to	ADP
admet-995	86	23	chi	chi	PROPN
admet-995	86	24	values	value	NOUN
admet-995	86	25	.	.	PUNCT
admet-995	87	1	table	table	NOUN
admet-995	87	2	1	1	NUM
admet-995	87	3	.	.	PUNCT
admet-995	88	1	the	the	DET
admet-995	88	2	chi	chi	ADJ
admet-995	88	3	values	value	NOUN
admet-995	88	4	of	of	ADP
admet-995	88	5	the	the	DET
admet-995	88	6	calibration	calibration	NOUN
admet-995	88	7	set	set	NOUN
admet-995	88	8	of	of	ADP
admet-995	88	9	compounds	compound	NOUN
admet-995	88	10	at	at	ADP
admet-995	88	11	three	three	NUM
admet-995	88	12	phs	ph	NOUN
admet-995	88	13	[	[	X
admet-995	88	14	33	33	NUM
admet-995	88	15	]	]	PUNCT
admet-995	88	16	.	.	PUNCT
admet-995	89	1	these	these	DET
admet-995	89	2	values	value	NOUN
admet-995	89	3	were	be	AUX
admet-995	89	4	obtained	obtain	VERB
admet-995	89	5	by	by	ADP
admet-995	89	6	fitting	fit	VERB
admet-995	89	7	the	the	DET
admet-995	89	8	isocratically	isocratically	ADV
admet-995	89	9	determined	determined	ADJ
admet-995	89	10	chi	chi	ADJ
admet-995	89	11	values	value	NOUN
admet-995	89	12	and	and	CCONJ
admet-995	89	13	the	the	DET
admet-995	89	14	gradient	gradient	ADJ
admet-995	89	15	retention	retention	NOUN
admet-995	89	16	time	time	NOUN
admet-995	89	17	values	value	NOUN
admet-995	89	18	.	.	PUNCT
admet-995	90	1	the	the	DET
admet-995	90	2	standard	standard	ADJ
admet-995	90	3	error	error	NOUN
admet-995	90	4	ranged	range	VERB
admet-995	90	5	from	from	ADP
admet-995	90	6	0.1	0.1	NUM
admet-995	90	7	to	to	PART
admet-995	90	8	0.8	0.8	NUM
admet-995	90	9	chi	chi	ADJ
admet-995	90	10	values	value	NOUN
admet-995	90	11	.	.	PUNCT
admet-995	91	1	chi	chi	PROPN
admet-995	91	2	approximates	approximate	VERB
admet-995	91	3	to	to	ADP
admet-995	91	4	the	the	DET
admet-995	91	5	acetonitrile	acetonitrile	ADJ
admet-995	91	6	concentration	concentration	NOUN
admet-995	91	7	when	when	SCONJ
admet-995	91	8	the	the	DET
admet-995	91	9	compound	compound	NOUN
admet-995	91	10	elutes	elute	NOUN
admet-995	91	11	and	and	CCONJ
admet-995	91	12	can	can	AUX
admet-995	91	13	be	be	AUX
admet-995	91	14	converted	convert	VERB
admet-995	91	15	to	to	ADP
admet-995	91	16	the	the	DET
admet-995	91	17	octanol	octanol	NOUN
admet-995	91	18	/	/	SYM
admet-995	91	19	water	water	NOUN
admet-995	91	20	log	log	NOUN
admet-995	91	21	d	d	NOUN
admet-995	91	22	scale	scale	NOUN
admet-995	91	23	using	use	VERB
admet-995	91	24	chi	chi	PROPN
admet-995	91	25	log	log	PROPN
admet-995	92	1	d	d	NOUN
admet-995	92	2	=	=	SYM
admet-995	92	3	0.0525*chi	0.0525*chi	NUM
admet-995	92	4	-1.467	-1.467	PUNCT
admet-995	93	1	[	[	X
admet-995	93	2	35	35	NUM
admet-995	93	3	]	]	PUNCT
admet-995	93	4	.	.	PUNCT
admet-995	94	1	compound	compound	NOUN
admet-995	94	2	chi	chi	NOUN
admet-995	94	3	at	at	ADP
admet-995	94	4	ph	ph	PROPN
admet-995	94	5	2.6	2.6	NUM
admet-995	94	6	chi	chi	NOUN
admet-995	94	7	at	at	ADP
admet-995	94	8	ph	ph	PROPN
admet-995	94	9	7.4	7.4	NUM
admet-995	94	10	chi	chi	NOUN
admet-995	94	11	at	at	ADP
admet-995	94	12	ph	ph	PROPN
admet-995	94	13	10.5	10.5	NUM
admet-995	94	14	theophylline	theophylline	NOUN
admet-995	94	15	17.9	17.9	NUM
admet-995	94	16	18.4	18.4	NUM
admet-995	94	17	5.0	5.0	NUM
admet-995	94	18	phenyl	phenyl	NOUN
admet-995	94	19	tetrazole	tetrazole	NOUN
admet-995	94	20	42.2	42.2	NUM
admet-995	94	21	23.6	23.6	NUM
admet-995	94	22	16.0	16.0	NUM
admet-995	94	23	benzimidazole	benzimidazole	NOUN
admet-995	94	24	6.3	6.3	NUM
admet-995	94	25	34.3	34.3	NUM
admet-995	94	26	30.6	30.6	NUM
admet-995	94	27	colchicine	colchicine	NOUN
admet-995	94	28	43.9	43.9	NUM
admet-995	94	29	45.0	45.0	NUM
admet-995	94	30	43.9	43.9	NUM
admet-995	94	31	phenyl	phenyl	NOUN
admet-995	94	32	theophylline	theophylline	NOUN
admet-995	94	33	51.7	51.7	NUM
admet-995	94	34	51.2	51.2	NUM
admet-995	94	35	51.3	51.3	NUM
admet-995	94	36	acetophenone	acetophenone	NOUN
admet-995	94	37	64.1	64.1	NUM
admet-995	94	38	65.1	65.1	NUM
admet-995	94	39	64.1	64.1	NUM
admet-995	94	40	indole	indole	NOUN
admet-995	94	41	72.1	72.1	NUM
admet-995	94	42	71.5	71.5	NUM
admet-995	94	43	72.1	72.1	NUM
admet-995	94	44	propiophenone	propiophenone	NOUN
admet-995	94	45	77.4	77.4	NUM
admet-995	94	46	77.4	77.4	NUM
admet-995	94	47	77.4	77.4	NUM
admet-995	94	48	butyrophenone	butyrophenone	NOUN
admet-995	94	49	87.3	87.3	NUM
admet-995	94	50	87.5	87.5	NUM
admet-995	94	51	87.3	87.3	NUM
admet-995	94	52	valerophenone	valerophenone	NOUN
admet-995	94	53	96.4	96.4	NUM
admet-995	94	54	96.2	96.2	NUM
admet-995	94	55	96.4	96.4	NUM
admet-995	94	56	measurements	measurement	NOUN
admet-995	94	57	of	of	ADP
admet-995	94	58	plasma	plasma	NOUN
admet-995	94	59	protein	protein	NOUN
admet-995	94	60	binding	bind	VERB
admet-995	94	61	using	use	VERB
admet-995	94	62	chiralpak	chiralpak	PROPN
admet-995	94	63	hsa	hsa	PROPN
admet-995	94	64	and	and	CCONJ
admet-995	94	65	agp	agp	PROPN
admet-995	94	66	columns	column	NOUN
admet-995	94	67	the	the	DET
admet-995	94	68	protein	protein	NOUN
admet-995	94	69	binding	bind	VERB
admet-995	94	70	measurements	measurement	NOUN
admet-995	94	71	were	be	AUX
admet-995	94	72	carried	carry	VERB
admet-995	94	73	out	out	ADP
admet-995	94	74	on	on	ADP
admet-995	94	75	chiralpak	chiralpak	PROPN
admet-995	94	76	hsa	hsa	PROPN
admet-995	94	77	and	and	CCONJ
admet-995	94	78	chiralpak	chiralpak	VERB
admet-995	94	79	agp	agp	PROPN
admet-995	94	80	columns	column	NOUN
admet-995	94	81	with	with	ADP
admet-995	94	82	dimensions	dimension	NOUN
admet-995	94	83	of	of	ADP
admet-995	94	84	3	3	NUM
admet-995	94	85	x	x	SYM
admet-995	94	86	50	50	NUM
admet-995	94	87	mm	mm	NOUN
admet-995	94	88	and	and	CCONJ
admet-995	94	89	5	5	NUM
admet-995	94	90	μm	μm	NOUN
admet-995	94	91	particle	particle	NOUN
admet-995	94	92	size	size	NOUN
admet-995	94	93	(	(	PUNCT
admet-995	94	94	chiral	chiral	ADJ
admet-995	94	95	technologies	technology	NOUN
admet-995	94	96	europe	europe	PROPN
admet-995	94	97	,	,	PUNCT
admet-995	94	98	france	france	PROPN
admet-995	94	99	)	)	PUNCT
admet-995	94	100	.	.	PUNCT
admet-995	95	1	the	the	DET
admet-995	95	2	mobile	mobile	ADJ
admet-995	95	3	phase	phase	NOUN
admet-995	95	4	was	be	AUX
admet-995	95	5	50	50	NUM
admet-995	95	6	mm	mm	NOUN
admet-995	95	7	ammonium	ammonium	NOUN
admet-995	95	8	acetate	acetate	NOUN
admet-995	95	9	adjusted	adjust	VERB
admet-995	95	10	to	to	ADP
admet-995	95	11	ph	ph	PROPN
admet-995	95	12	7.4	7.4	NUM
admet-995	95	13	,	,	PUNCT
admet-995	95	14	with	with	ADP
admet-995	95	15	a	a	DET
admet-995	95	16	1.2	1.2	NUM
admet-995	95	17	ml	ml	NOUN
admet-995	95	18	/	/	SYM
admet-995	95	19	min	min	NOUN
admet-995	95	20	flow	flow	NOUN
admet-995	95	21	rate	rate	NOUN
admet-995	95	22	.	.	PUNCT
admet-995	96	1	the	the	DET
admet-995	96	2	standard	standard	ADJ
admet-995	96	3	isopropanol	isopropanol	NOUN
admet-995	96	4	(	(	PUNCT
admet-995	96	5	ipa	ipa	PROPN
admet-995	96	6	)	)	PUNCT
admet-995	96	7	gradient	gradient	NOUN
admet-995	96	8	reached	reach	VERB
admet-995	96	9	35	35	NUM
admet-995	96	10	%	%	NOUN
admet-995	96	11	in	in	ADP
admet-995	96	12	3.5	3.5	NUM
admet-995	96	13	min	min	NOUN
admet-995	96	14	,	,	PUNCT
admet-995	96	15	which	which	PRON
admet-995	96	16	was	be	AUX
admet-995	96	17	maintained	maintain	VERB
admet-995	96	18	for	for	ADP
admet-995	96	19	1	1	NUM
admet-995	96	20	min	min	NOUN
admet-995	96	21	,	,	PUNCT
admet-995	96	22	before	before	ADP
admet-995	96	23	returning	return	VERB
admet-995	96	24	to	to	ADP
admet-995	96	25	0	0	NUM
admet-995	96	26	%	%	NOUN
admet-995	96	27	at	at	ADP
admet-995	96	28	4.7	4.7	NUM
admet-995	96	29	min	min	NOUN
admet-995	96	30	.	.	PUNCT
admet-995	97	1	the	the	DET
admet-995	97	2	cycle	cycle	NOUN
admet-995	97	3	time	time	NOUN
admet-995	97	4	was	be	AUX
admet-995	97	5	6	6	NUM
admet-995	97	6	min	min	NOUN
admet-995	97	7	with	with	ADP
admet-995	97	8	an	an	DET
admet-995	97	9	additional	additional	ADJ
admet-995	97	10	1	1	NUM
admet-995	97	11	min	min	NOUN
admet-995	97	12	re	re	NOUN
admet-995	97	13	-	-	NOUN
admet-995	97	14	equilibration	equilibration	NOUN
admet-995	97	15	time	time	NOUN
admet-995	97	16	.	.	PUNCT
admet-995	98	1	the	the	DET
admet-995	98	2	racemic	racemic	ADJ
admet-995	98	3	warfarin	warfarin	NOUN
admet-995	98	4	showed	show	VERB
admet-995	98	5	separation	separation	NOUN
admet-995	98	6	of	of	ADP
admet-995	98	7	its	its	PRON
admet-995	98	8	enantiomers	enantiomer	NOUN
admet-995	98	9	at	at	ADP
admet-995	98	10	retention	retention	NOUN
admet-995	98	11	times	time	NOUN
admet-995	98	12	of	of	ADP
admet-995	98	13	3.58	3.58	NUM
admet-995	98	14	and	and	CCONJ
admet-995	98	15	3.77	3.77	NUM
admet-995	98	16	min	min	NOUN
admet-995	98	17	.	.	PUNCT
admet-995	99	1	the	the	DET
admet-995	99	2	precision	precision	NOUN
admet-995	99	3	of	of	ADP
admet-995	99	4	the	the	DET
admet-995	99	5	retention	retention	NOUN
admet-995	99	6	time	time	NOUN
admet-995	99	7	measurements	measurement	NOUN
admet-995	99	8	was	be	AUX
admet-995	99	9	within	within	ADP
admet-995	99	10	±0.01	±0.01	PROPN
admet-995	99	11	min	min	PROPN
admet-995	99	12	.	.	PUNCT
admet-995	100	1	the	the	DET
admet-995	100	2	calibration	calibration	NOUN
admet-995	100	3	set	set	NOUN
admet-995	100	4	of	of	ADP
admet-995	100	5	compounds	compound	NOUN
admet-995	100	6	and	and	CCONJ
admet-995	100	7	their	their	PRON
admet-995	100	8	literature	literature	NOUN
admet-995	100	9	%	%	NOUN
admet-995	100	10	binding	bind	VERB
admet-995	100	11	data	datum	NOUN
admet-995	100	12	which	which	PRON
admet-995	100	13	were	be	AUX
admet-995	100	14	also	also	ADV
admet-995	100	15	converted	convert	VERB
admet-995	100	16	to	to	PART
admet-995	100	17	log	log	VERB
admet-995	100	18	k	k	PROPN
admet-995	100	19	data	datum	NOUN
admet-995	100	20	are	be	AUX
admet-995	100	21	shown	show	VERB
admet-995	100	22	in	in	ADP
admet-995	100	23	table	table	NOUN
admet-995	100	24	2	2	NUM
admet-995	100	25	.	.	PUNCT
admet-995	100	26	table	table	NOUN
admet-995	100	27	2	2	NUM
admet-995	100	28	.	.	PUNCT
admet-995	101	1	the	the	DET
admet-995	101	2	protein	protein	NOUN
admet-995	101	3	binding	bind	VERB
admet-995	101	4	data	datum	NOUN
admet-995	101	5	of	of	ADP
admet-995	101	6	the	the	DET
admet-995	101	7	marketed	market	VERB
admet-995	101	8	drug	drug	NOUN
admet-995	101	9	molecules	molecule	NOUN
admet-995	101	10	that	that	PRON
admet-995	101	11	were	be	AUX
admet-995	101	12	used	use	VERB
admet-995	101	13	to	to	PART
admet-995	101	14	calibrate	calibrate	VERB
admet-995	101	15	the	the	DET
admet-995	101	16	retention	retention	NOUN
admet-995	101	17	times	time	NOUN
admet-995	101	18	obtained	obtain	VERB
admet-995	101	19	on	on	ADP
admet-995	101	20	the	the	DET
admet-995	101	21	chiral	chiral	ADJ
admet-995	101	22	protein	protein	NOUN
admet-995	101	23	columns	column	NOUN
admet-995	101	24	(	(	PUNCT
admet-995	101	25	chiralpak	chiralpak	PROPN
admet-995	101	26	hsa	hsa	PROPN
admet-995	101	27	and	and	CCONJ
admet-995	101	28	chiralpak	chiralpak	VERB
admet-995	101	29	agp	agp	PROPN
admet-995	101	30	)	)	PUNCT
admet-995	101	31	.	.	PUNCT
admet-995	102	1	the	the	DET
admet-995	102	2	%	%	NOUN
admet-995	102	3	binding	bind	VERB
admet-995	102	4	data	datum	NOUN
admet-995	102	5	obtained	obtain	VERB
admet-995	102	6	by	by	ADP
admet-995	102	7	equilibrium	equilibrium	NOUN
admet-995	102	8	dialysis	dialysis	NOUN
admet-995	102	9	were	be	AUX
admet-995	102	10	converted	convert	VERB
admet-995	102	11	to	to	PART
admet-995	102	12	log	log	VERB
admet-995	102	13	k	k	PROPN
admet-995	102	14	data	datum	NOUN
admet-995	102	15	using	use	VERB
admet-995	102	16	log	log	NOUN
admet-995	103	1	k	k	PROPN
admet-995	103	2	=	=	PUNCT
admet-995	103	3	log	log	NOUN
admet-995	103	4	(	(	PUNCT
admet-995	103	5	%	%	INTJ
admet-995	103	6	binding/(101-%binding	binding/(101-%binding	NOUN
admet-995	103	7	)	)	PUNCT
admet-995	103	8	)	)	PUNCT
admet-995	103	9	.	.	PUNCT
admet-995	104	1	compound	compound	NOUN
admet-995	104	2	name	name	NOUN
admet-995	105	1	%	%	INTJ
admet-995	105	2	hsa	hsa	INTJ
admet-995	105	3	log	log	NOUN
admet-995	106	1	k	k	PROPN
admet-995	106	2	hsa	hsa	PROPN
admet-995	106	3	%	%	NOUN
admet-995	106	4	agp	agp	PROPN
admet-995	106	5	log	log	NOUN
admet-995	106	6	k	k	PROPN
admet-995	106	7	agp	agp	PROPN
admet-995	106	8	warfarin	warfarin	NOUN
admet-995	106	9	97.9	97.9	NUM
admet-995	106	10	1.5	1.5	NUM
admet-995	106	11	83.2	83.2	NUM
admet-995	106	12	0.7	0.7	NUM
admet-995	106	13	paracetamol	paracetamol	NOUN
admet-995	106	14	14.0	14.0	NUM
admet-995	106	15	-0.8	-0.8	NUM
admet-995	106	16	3.2	3.2	NUM
admet-995	106	17	-1.5	-1.5	NOUN
admet-995	106	18	nizatidine	nizatidine	NOUN
admet-995	106	19	20.4	20.4	NUM
admet-995	106	20	-0.6	-0.6	NUM
admet-995	106	21	37.1	37.1	NUM
admet-995	106	22	-0.2	-0.2	NOUN
admet-995	106	23	trimethoprim	trimethoprim	NOUN
admet-995	106	24	37.6	37.6	NUM
admet-995	106	25	-0.2	-0.2	NUM
admet-995	106	26	46.2	46.2	NUM
admet-995	106	27	-0.1	-0.1	PROPN
admet-995	106	28	propranolol	propranolol	PROPN
admet-995	106	29	66.6	66.6	NUM
admet-995	106	30	0.3	0.3	NUM
admet-995	106	31	86.0	86.0	NUM
admet-995	106	32	0.8	0.8	NUM
admet-995	106	33	carbamazepine	carbamazepine	NOUN
admet-995	106	34	75.0	75.0	NUM
admet-995	106	35	0.5	0.5	NUM
admet-995	106	36	65.0	65.0	NUM
admet-995	106	37	0.3	0.3	NUM
admet-995	106	38	nicardipine	nicardipine	NOUN
admet-995	106	39	95.0	95.0	NUM
admet-995	106	40	1.2	1.2	NUM
admet-995	106	41	87.0	87.0	NUM
admet-995	106	42	0.8	0.8	NUM
admet-995	106	43	indomethacin	indomethacin	VERB
admet-995	106	44	99.5	99.5	NUM
admet-995	106	45	1.8	1.8	NUM
admet-995	106	46	56.0	56.0	NUM
admet-995	106	47	0.1	0.1	NUM
admet-995	106	48	diclofenac	diclofenac	NOUN
admet-995	106	49	99.8	99.8	NUM
admet-995	106	50	1.9	1.9	NUM
admet-995	106	51	60.0	60.0	NUM
admet-995	106	52	0.2	0.2	NUM
admet-995	106	53	admet	admet	PROPN
admet-995	106	54	&	&	CCONJ
admet-995	106	55	dmpk	dmpk	PROPN
admet-995	106	56	9(3	9(3	NUM
admet-995	106	57	)	)	PUNCT
admet-995	106	58	(	(	PUNCT
admet-995	106	59	2021	2021	NUM
admet-995	106	60	)	)	PUNCT
admet-995	106	61	191	191	NUM
admet-995	106	62	-	-	SYM
admet-995	106	63	207	207	NUM
admet-995	106	64	prediction	prediction	NOUN
admet-995	106	65	of	of	ADP
admet-995	106	66	herg	herg	PROPN
admet-995	106	67	inhibition	inhibition	NOUN
admet-995	106	68	by	by	ADP
admet-995	106	69	biomimetic	biomimetic	ADJ
admet-995	106	70	measurements	measurement	NOUN
admet-995	106	71	doi	doi	NOUN
admet-995	106	72	:	:	PUNCT
admet-995	106	73	http://dx.doi.org/10.5599/admet.995	http://dx.doi.org/10.5599/admet.995	ADJ
admet-995	106	74	195	195	NUM
admet-995	106	75	measurements	measurement	NOUN
admet-995	106	76	of	of	ADP
admet-995	106	77	phospholipid	phospholipid	NOUN
admet-995	106	78	-	-	PUNCT
admet-995	106	79	binding	bind	VERB
admet-995	106	80	at	at	ADP
admet-995	106	81	ph	ph	PROPN
admet-995	106	82	7.4	7.4	NUM
admet-995	106	83	using	use	VERB
admet-995	106	84	an	an	DET
admet-995	106	85	iam	iam	PROPN
admet-995	106	86	column	column	NOUN
admet-995	106	87	the	the	DET
admet-995	106	88	phospholipid	phospholipid	NOUN
admet-995	106	89	-	-	PUNCT
admet-995	106	90	binding	bind	VERB
admet-995	106	91	was	be	AUX
admet-995	106	92	measured	measure	VERB
admet-995	106	93	using	use	VERB
admet-995	106	94	an	an	DET
admet-995	106	95	iam	iam	PROPN
admet-995	106	96	pc.dd2	pc.dd2	PROPN
admet-995	106	97	column	column	NOUN
admet-995	106	98	with	with	ADP
admet-995	106	99	dimensions	dimension	NOUN
admet-995	106	100	of	of	ADP
admet-995	106	101	100	100	NUM
admet-995	106	102	x	x	SYM
admet-995	106	103	4.6	4.6	NUM
admet-995	106	104	mm	mm	INTJ
admet-995	106	105	(	(	PUNCT
admet-995	106	106	regis	regis	PROPN
admet-995	106	107	technologies	technologies	PROPN
admet-995	106	108	inc	inc	PROPN
admet-995	106	109	.	.	PROPN
admet-995	106	110	,	,	PUNCT
admet-995	106	111	morton	morton	PROPN
admet-995	106	112	grove	grove	PROPN
admet-995	106	113	,	,	PUNCT
admet-995	106	114	il	il	PROPN
admet-995	106	115	,	,	PUNCT
admet-995	106	116	usa	usa	PROPN
admet-995	106	117	)	)	PUNCT
admet-995	106	118	.	.	PUNCT
admet-995	107	1	the	the	DET
admet-995	107	2	gradient	gradient	ADJ
admet-995	107	3	retention	retention	NOUN
admet-995	107	4	times	time	NOUN
admet-995	107	5	were	be	AUX
admet-995	107	6	measured	measure	VERB
admet-995	107	7	using	use	VERB
admet-995	107	8	a	a	DET
admet-995	107	9	50	50	NUM
admet-995	107	10	mm	mm	NOUN
admet-995	107	11	ammonium	ammonium	NOUN
admet-995	107	12	acetate	acetate	NOUN
admet-995	107	13	mobile	mobile	ADJ
admet-995	107	14	phase	phase	NOUN
admet-995	107	15	with	with	ADP
admet-995	107	16	the	the	DET
admet-995	107	17	ph	ph	NOUN
admet-995	107	18	adjusted	adjust	VERB
admet-995	107	19	to	to	ADP
admet-995	107	20	7.4	7.4	NUM
admet-995	107	21	.	.	PUNCT
admet-995	108	1	the	the	DET
admet-995	108	2	mobile	mobile	ADJ
admet-995	108	3	phase	phase	NOUN
admet-995	108	4	flow	flow	NOUN
admet-995	108	5	rate	rate	NOUN
admet-995	108	6	was	be	AUX
admet-995	108	7	1.5	1.5	NUM
admet-995	108	8	ml	ml	NOUN
admet-995	108	9	/	/	SYM
admet-995	108	10	min	min	NOUN
admet-995	108	11	.	.	PUNCT
admet-995	109	1	the	the	DET
admet-995	109	2	acetonitrile	acetonitrile	ADJ
admet-995	109	3	gradient	gradient	NOUN
admet-995	109	4	was	be	AUX
admet-995	109	5	applied	apply	VERB
admet-995	109	6	to	to	PART
admet-995	109	7	reach	reach	VERB
admet-995	109	8	90	90	NUM
admet-995	109	9	%	%	NOUN
admet-995	109	10	in	in	ADP
admet-995	109	11	4.75	4.75	NUM
admet-995	109	12	min	min	NOUN
admet-995	109	13	.	.	PUNCT
admet-995	110	1	the	the	DET
admet-995	110	2	90	90	NUM
admet-995	110	3	%	%	NOUN
admet-995	110	4	acetonitrile	acetonitrile	ADJ
admet-995	110	5	concentration	concentration	NOUN
admet-995	110	6	was	be	AUX
admet-995	110	7	maintained	maintain	VERB
admet-995	110	8	for	for	ADP
admet-995	110	9	an	an	DET
admet-995	110	10	additional	additional	ADJ
admet-995	110	11	0.5	0.5	NUM
admet-995	110	12	min	min	NOUN
admet-995	110	13	(	(	PUNCT
admet-995	110	14	to	to	ADP
admet-995	110	15	5.25	5.25	NUM
admet-995	110	16	min	min	NOUN
admet-995	110	17	)	)	PUNCT
admet-995	110	18	and	and	CCONJ
admet-995	110	19	returned	return	VERB
admet-995	110	20	to	to	ADP
admet-995	110	21	0	0	NUM
admet-995	110	22	%	%	NOUN
admet-995	110	23	by	by	ADP
admet-995	110	24	5.5	5.5	NUM
admet-995	110	25	min	min	NOUN
admet-995	110	26	.	.	PUNCT
admet-995	111	1	the	the	DET
admet-995	111	2	cycle	cycle	NOUN
admet-995	111	3	time	time	NOUN
admet-995	111	4	was	be	AUX
admet-995	111	5	6	6	NUM
admet-995	111	6	min	min	NOUN
admet-995	111	7	,	,	PUNCT
admet-995	111	8	plus	plus	CCONJ
admet-995	111	9	an	an	DET
admet-995	111	10	additional	additional	ADJ
admet-995	111	11	1	1	NUM
admet-995	111	12	min	min	NOUN
admet-995	111	13	equilibration	equilibration	NOUN
admet-995	111	14	time	time	NOUN
admet-995	111	15	was	be	AUX
admet-995	111	16	applied	apply	VERB
admet-995	111	17	while	while	SCONJ
admet-995	111	18	the	the	DET
admet-995	111	19	injector	injector	NOUN
admet-995	111	20	prepared	prepare	VERB
admet-995	111	21	for	for	ADP
admet-995	111	22	the	the	DET
admet-995	111	23	next	next	ADJ
admet-995	111	24	injection	injection	NOUN
admet-995	111	25	.	.	PUNCT
admet-995	112	1	the	the	DET
admet-995	112	2	gradient	gradient	ADJ
admet-995	112	3	retention	retention	NOUN
admet-995	112	4	times	time	NOUN
admet-995	112	5	were	be	AUX
admet-995	112	6	calibrated	calibrate	VERB
admet-995	112	7	with	with	ADP
admet-995	112	8	the	the	DET
admet-995	112	9	acetophenone	acetophenone	NOUN
admet-995	112	10	homologues	homologue	NOUN
admet-995	112	11	for	for	ADP
admet-995	112	12	which	which	PRON
admet-995	112	13	the	the	DET
admet-995	112	14	chi	chi	PROPN
admet-995	112	15	iam	iam	PROPN
admet-995	112	16	values	value	NOUN
admet-995	112	17	have	have	AUX
admet-995	112	18	been	be	AUX
admet-995	112	19	established	establish	VERB
admet-995	112	20	using	use	VERB
admet-995	112	21	isocratic	isocratic	ADJ
admet-995	112	22	measurements	measurement	NOUN
admet-995	112	23	[	[	X
admet-995	112	24	34	34	NUM
admet-995	112	25	]	]	PUNCT
admet-995	112	26	.	.	PUNCT
admet-995	113	1	table	table	NOUN
admet-995	113	2	3	3	NUM
admet-995	113	3	shows	show	VERB
admet-995	113	4	the	the	DET
admet-995	113	5	calibration	calibration	NOUN
admet-995	113	6	set	set	NOUN
admet-995	113	7	of	of	ADP
admet-995	113	8	compounds	compound	NOUN
admet-995	113	9	and	and	CCONJ
admet-995	113	10	their	their	PRON
admet-995	113	11	predetermined	predetermine	VERB
admet-995	113	12	chi	chi	PROPN
admet-995	113	13	iam	iam	PROPN
admet-995	113	14	values	value	NOUN
admet-995	113	15	.	.	PUNCT
admet-995	114	1	the	the	DET
admet-995	114	2	chi	chi	PROPN
admet-995	114	3	index	index	NOUN
admet-995	114	4	on	on	ADP
admet-995	114	5	the	the	DET
admet-995	114	6	iam	iam	PROPN
admet-995	114	7	column	column	NOUN
admet-995	114	8	(	(	PUNCT
admet-995	114	9	chi	chi	PROPN
admet-995	114	10	iam	iam	PROPN
admet-995	114	11	)	)	PUNCT
admet-995	114	12	approximates	approximate	VERB
admet-995	114	13	the	the	DET
admet-995	114	14	acetonitrile	acetonitrile	ADJ
admet-995	114	15	concentration	concentration	NOUN
admet-995	114	16	in	in	ADP
admet-995	114	17	the	the	DET
admet-995	114	18	mobile	mobile	ADJ
admet-995	114	19	phase	phase	NOUN
admet-995	114	20	when	when	SCONJ
admet-995	114	21	the	the	DET
admet-995	114	22	compound	compound	NOUN
admet-995	114	23	elutes	elute	NOUN
admet-995	114	24	.	.	PUNCT
admet-995	115	1	chi	chi	PROPN
admet-995	115	2	iam	iam	PROPN
admet-995	115	3	values	value	NOUN
admet-995	115	4	above	above	ADP
admet-995	115	5	45	45	NUM
admet-995	115	6	indicate	indicate	VERB
admet-995	115	7	strong	strong	ADJ
admet-995	115	8	phospholipid	phospholipid	NOUN
admet-995	115	9	binding	bind	VERB
admet-995	115	10	.	.	PUNCT
admet-995	116	1	the	the	DET
admet-995	116	2	chi	chi	PROPN
admet-995	116	3	iam	iam	PROPN
admet-995	116	4	values	value	NOUN
admet-995	116	5	have	have	AUX
admet-995	116	6	been	be	AUX
admet-995	116	7	converted	convert	VERB
admet-995	116	8	to	to	PART
admet-995	116	9	log	log	VERB
admet-995	116	10	k	k	PROPN
admet-995	116	11	iam	iam	PROPN
admet-995	116	12	values	value	NOUN
admet-995	116	13	derived	derive	VERB
admet-995	116	14	from	from	ADP
admet-995	116	15	the	the	DET
admet-995	116	16	chi	chi	PROPN
admet-995	116	17	iam	iam	PROPN
admet-995	116	18	values	value	NOUN
admet-995	116	19	using	use	VERB
admet-995	116	20	equation	equation	NOUN
admet-995	116	21	1	1	NUM
admet-995	116	22	.	.	PUNCT
admet-995	117	1	it	it	PRON
admet-995	117	2	represents	represent	VERB
admet-995	117	3	the	the	DET
admet-995	117	4	equivalent	equivalent	ADJ
admet-995	117	5	value	value	NOUN
admet-995	117	6	derived	derive	VERB
admet-995	117	7	from	from	ADP
admet-995	117	8	several	several	ADJ
admet-995	117	9	isocratic	isocratic	ADJ
admet-995	117	10	measurements	measurement	NOUN
admet-995	117	11	with	with	ADP
admet-995	117	12	extrapolated	extrapolated	ADJ
admet-995	117	13	log	log	NOUN
admet-995	117	14	retention	retention	NOUN
admet-995	117	15	factors	factor	NOUN
admet-995	117	16	to	to	ADP
admet-995	117	17	100	100	NUM
admet-995	117	18	%	%	NOUN
admet-995	117	19	aqueous	aqueous	ADJ
admet-995	117	20	mobile	mobile	ADJ
admet-995	117	21	phase	phase	NOUN
admet-995	117	22	[	[	X
admet-995	117	23	23	23	NUM
admet-995	117	24	]	]	PUNCT
admet-995	117	25	.	.	PUNCT
admet-995	118	1	the	the	DET
admet-995	118	2	log	log	NOUN
admet-995	118	3	k	k	PROPN
admet-995	118	4	iam	iam	PROPN
admet-995	118	5	values	value	NOUN
admet-995	118	6	can	can	AUX
admet-995	118	7	be	be	AUX
admet-995	118	8	converted	convert	VERB
admet-995	118	9	to	to	PART
admet-995	118	10	log	log	VERB
admet-995	118	11	k	k	PROPN
admet-995	118	12	(	(	PUNCT
admet-995	118	13	iam	iam	PROPN
admet-995	118	14	)	)	PUNCT
admet-995	118	15	values	value	NOUN
admet-995	118	16	and	and	CCONJ
admet-995	118	17	show	show	VERB
admet-995	118	18	linear	linear	ADJ
admet-995	118	19	relationships	relationship	NOUN
admet-995	118	20	with	with	ADP
admet-995	118	21	the	the	DET
admet-995	118	22	octanol	octanol	NOUN
admet-995	118	23	/	/	SYM
admet-995	118	24	water	water	NOUN
admet-995	118	25	partition	partition	NOUN
admet-995	118	26	coefficients	coefficient	NOUN
admet-995	118	27	[	[	X
admet-995	118	28	26	26	NUM
admet-995	118	29	]	]	PUNCT
admet-995	118	30	.	.	PUNCT
admet-995	119	1	equation	equation	NOUN
admet-995	119	2	2	2	NUM
admet-995	119	3	shows	show	VERB
admet-995	119	4	the	the	DET
admet-995	119	5	conversion	conversion	NOUN
admet-995	119	6	:	:	PUNCT
admet-995	119	7	log	log	VERB
admet-995	119	8	k	k	PROPN
admet-995	119	9	iam	iam	PROPN
admet-995	119	10	=	=	NOUN
admet-995	119	11	0.045	0.045	NUM
admet-995	119	12	*	*	PUNCT
admet-995	119	13	chi	chi	PROPN
admet-995	119	14	iam	iam	PROPN
admet-995	120	1	+	+	CCONJ
admet-995	120	2	0.42	0.42	NUM
admet-995	120	3	(	(	PUNCT
admet-995	120	4	1	1	NUM
admet-995	120	5	)	)	PUNCT
admet-995	120	6	log	log	NOUN
admet-995	120	7	k	k	PROPN
admet-995	120	8	iam	iam	PROPN
admet-995	121	1	=	=	PROPN
admet-995	121	2	0.29	0.29	NUM
admet-995	121	3	e(0.045chi	e(0.045chi	PROPN
admet-995	121	4	iam	iam	PROPN
admet-995	121	5	+0.42	+0.42	PROPN
admet-995	121	6	)	)	PUNCT
admet-995	121	7	+0.7	+0.7	NOUN
admet-995	121	8	(	(	PUNCT
admet-995	121	9	2	2	X
admet-995	121	10	)	)	PUNCT
admet-995	121	11	repeating	repeat	VERB
admet-995	121	12	the	the	DET
admet-995	121	13	retention	retention	NOUN
admet-995	121	14	time	time	NOUN
admet-995	121	15	measurements	measurement	NOUN
admet-995	121	16	provided	provide	VERB
admet-995	121	17	a	a	DET
admet-995	121	18	standard	standard	ADJ
admet-995	121	19	deviation	deviation	NOUN
admet-995	121	20	of	of	ADP
admet-995	121	21	±0.005	±0.005	NOUN
admet-995	121	22	min	min	PROPN
admet-995	121	23	.	.	PROPN
admet-995	121	24	table	table	NOUN
admet-995	121	25	3	3	NUM
admet-995	121	26	.	.	PUNCT
admet-995	122	1	the	the	DET
admet-995	122	2	calibration	calibration	NOUN
admet-995	122	3	set	set	NOUN
admet-995	122	4	of	of	ADP
admet-995	122	5	compounds	compound	NOUN
admet-995	122	6	used	use	VERB
admet-995	122	7	on	on	ADP
admet-995	122	8	the	the	DET
admet-995	122	9	iam.pc.dd2	iam.pc.dd2	PROPN
admet-995	122	10	hplc	hplc	NOUN
admet-995	122	11	column	column	NOUN
admet-995	122	12	and	and	CCONJ
admet-995	122	13	their	their	PRON
admet-995	122	14	predetermined	predetermine	VERB
admet-995	122	15	chi	chi	PROPN
admet-995	122	16	iam	iam	PROPN
admet-995	122	17	values	value	NOUN
admet-995	122	18	.	.	PUNCT
admet-995	123	1	database	database	NOUN
admet-995	123	2	search	search	NOUN
admet-995	123	3	for	for	ADP
admet-995	123	4	pic50	pic50	ADJ
admet-995	123	5	values	value	NOUN
admet-995	123	6	assessing	assess	VERB
admet-995	123	7	the	the	DET
admet-995	123	8	risk	risk	NOUN
admet-995	123	9	of	of	ADP
admet-995	123	10	a	a	DET
admet-995	123	11	blockade	blockade	NOUN
admet-995	123	12	of	of	ADP
admet-995	123	13	the	the	DET
admet-995	123	14	human	human	ADJ
admet-995	123	15	ether	ether	NOUN
admet-995	123	16	à	à	ADJ
admet-995	123	17	-	-	VERB
admet-995	123	18	go	go	NOUN
admet-995	123	19	-	-	PUNCT
admet-995	123	20	go	go	VERB
admet-995	123	21	related	relate	VERB
admet-995	123	22	gene	gene	NOUN
admet-995	123	23	potassium	potassium	NOUN
admet-995	123	24	channels	channel	NOUN
admet-995	123	25	could	could	AUX
admet-995	123	26	greatly	greatly	ADV
admet-995	123	27	facilitate	facilitate	VERB
admet-995	123	28	the	the	DET
admet-995	123	29	development	development	NOUN
admet-995	123	30	of	of	ADP
admet-995	123	31	therapeutic	therapeutic	ADJ
admet-995	123	32	compounds	compound	NOUN
admet-995	123	33	and	and	CCONJ
admet-995	123	34	the	the	DET
admet-995	123	35	withdrawal	withdrawal	NOUN
admet-995	123	36	of	of	ADP
admet-995	123	37	hazardous	hazardous	ADJ
admet-995	123	38	marketed	market	VERB
admet-995	123	39	drugs	drug	NOUN
admet-995	123	40	.	.	PUNCT
admet-995	124	1	the	the	DET
admet-995	124	2	development	development	NOUN
admet-995	124	3	of	of	ADP
admet-995	124	4	highthroughput	highthroughput	ADJ
admet-995	124	5	automated	automate	VERB
admet-995	124	6	patch	patch	NOUN
admet-995	124	7	clamp	clamp	NOUN
admet-995	124	8	assays	assay	NOUN
admet-995	124	9	has	have	AUX
admet-995	124	10	increased	increase	VERB
admet-995	124	11	the	the	DET
admet-995	124	12	amount	amount	NOUN
admet-995	124	13	of	of	ADP
admet-995	124	14	herg	herg	PROPN
admet-995	124	15	-	-	PUNCT
admet-995	124	16	associated	associate	VERB
admet-995	124	17	data	datum	NOUN
admet-995	124	18	available	available	ADJ
admet-995	124	19	in	in	ADP
admet-995	124	20	public	public	ADJ
admet-995	124	21	databases	database	NOUN
admet-995	124	22	[	[	X
admet-995	124	23	17	17	NUM
admet-995	124	24	]	]	PUNCT
admet-995	124	25	.	.	PUNCT
admet-995	125	1	integrated	integrate	VERB
admet-995	125	2	databases	database	NOUN
admet-995	125	3	are	be	AUX
admet-995	125	4	now	now	ADV
admet-995	125	5	available	available	ADJ
admet-995	125	6	using	use	VERB
admet-995	125	7	the	the	DET
admet-995	125	8	chembl	chembl	NOUN
admet-995	125	9	and	and	CCONJ
admet-995	125	10	pubchem	pubchem	NOUN
admet-995	125	11	public	public	ADJ
admet-995	125	12	databases	database	NOUN
admet-995	125	13	.	.	PUNCT
admet-995	126	1	a	a	DET
admet-995	126	2	large	large	ADJ
admet-995	126	3	integrated	integrate	VERB
admet-995	126	4	database	database	NOUN
admet-995	126	5	created	create	VERB
admet-995	126	6	by	by	ADP
admet-995	126	7	sato	sato	PROPN
admet-995	126	8	et	et	PROPN
admet-995	126	9	al	al	PROPN
admet-995	126	10	.	.	PUNCT
admet-995	127	1	[	[	X
admet-995	127	2	36	36	NUM
admet-995	127	3	]	]	PUNCT
admet-995	127	4	has	have	AUX
admet-995	127	5	been	be	AUX
admet-995	127	6	used	use	VERB
admet-995	127	7	in	in	ADP
admet-995	127	8	this	this	DET
admet-995	127	9	study	study	NOUN
admet-995	127	10	.	.	PUNCT
admet-995	128	1	this	this	DET
admet-995	128	2	database	database	NOUN
admet-995	128	3	curates	curate	VERB
admet-995	128	4	herg	herg	PROPN
admet-995	128	5	-	-	PUNCT
admet-995	128	6	related	relate	VERB
admet-995	128	7	data	datum	NOUN
admet-995	128	8	from	from	ADP
admet-995	128	9	in	in	ADP
admet-995	128	10	vitro	vitro	X
admet-995	128	11	assays	assay	NOUN
admet-995	128	12	,	,	PUNCT
admet-995	128	13	such	such	ADJ
admet-995	128	14	as	as	ADP
admet-995	128	15	binding	bind	VERB
admet-995	128	16	assays	assay	NOUN
admet-995	128	17	(	(	PUNCT
admet-995	128	18	radioligand	radioligand	NOUN
admet-995	128	19	replacement	replacement	NOUN
admet-995	128	20	assay	assay	PROPN
admet-995	128	21	)	)	PUNCT
admet-995	128	22	and	and	CCONJ
admet-995	128	23	electrostatic	electrostatic	ADJ
admet-995	128	24	assays	assay	NOUN
admet-995	128	25	(	(	PUNCT
admet-995	128	26	automated	automate	VERB
admet-995	128	27	patch	patch	ADJ
admet-995	128	28	-	-	PUNCT
admet-995	128	29	clamp	clamp	NOUN
admet-995	128	30	assays	assay	NOUN
admet-995	128	31	)	)	PUNCT
admet-995	128	32	,	,	PUNCT
admet-995	128	33	in	in	ADP
admet-995	128	34	chembl	chembl	NOUN
admet-995	128	35	,	,	PUNCT
admet-995	128	36	pubchem	pubchem	NOUN
admet-995	128	37	,	,	PUNCT
admet-995	128	38	gostar	gostar	NOUN
admet-995	128	39	,	,	PUNCT
admet-995	128	40	nih	nih	PROPN
admet-995	128	41	chemical	chemical	PROPN
admet-995	128	42	genomics	genomics	PROPN
admet-995	128	43	center	center	PROPN
admet-995	128	44	(	(	PUNCT
admet-995	128	45	ncgc	ncgc	NOUN
admet-995	128	46	)	)	PUNCT
admet-995	128	47	and	and	CCONJ
admet-995	128	48	hergcentral	hergcentral	ADJ
admet-995	128	49	and	and	CCONJ
admet-995	128	50	integrates	integrate	VERB
admet-995	128	51	them	they	PRON
admet-995	128	52	into	into	ADP
admet-995	128	53	the	the	DET
admet-995	128	54	largest	large	ADJ
admet-995	128	55	database	database	NOUN
admet-995	128	56	about	about	ADP
admet-995	128	57	herg	herg	PROPN
admet-995	128	58	inhibition	inhibition	NOUN
admet-995	128	59	.	.	PUNCT
admet-995	129	1	ic50	ic50	PROPN
admet-995	129	2	values	value	NOUN
admet-995	129	3	of	of	ADP
admet-995	129	4	the	the	DET
admet-995	129	5	compounds	compound	NOUN
admet-995	129	6	and	and	CCONJ
admet-995	129	7	their	their	PRON
admet-995	129	8	pic50	pic50	ADJ
admet-995	129	9	values	value	NOUN
admet-995	129	10	expressed	express	VERB
admet-995	129	11	in	in	ADP
admet-995	129	12	molar	molar	ADJ
admet-995	129	13	concentrations	concentration	NOUN
admet-995	129	14	were	be	AUX
admet-995	129	15	carefully	carefully	ADV
admet-995	129	16	searched	search	VERB
admet-995	129	17	and	and	CCONJ
admet-995	129	18	collected	collect	VERB
admet-995	129	19	from	from	ADP
admet-995	129	20	this	this	DET
admet-995	129	21	database	database	NOUN
admet-995	129	22	,	,	PUNCT
admet-995	129	23	which	which	PRON
admet-995	129	24	is	be	AUX
admet-995	129	25	freely	freely	ADV
admet-995	129	26	available	available	ADJ
admet-995	129	27	at	at	ADP
admet-995	129	28	https://drugdesign.riken.jp/hergdb/.	https://drugdesign.riken.jp/hergdb/.	PROPN
admet-995	129	29	data	datum	NOUN
admet-995	129	30	entries	entry	NOUN
admet-995	129	31	using	use	VERB
admet-995	129	32	inequality	inequality	NOUN
admet-995	129	33	signs	sign	NOUN
admet-995	129	34	,	,	PUNCT
admet-995	129	35	null	null	ADJ
admet-995	129	36	values	value	NOUN
admet-995	129	37	and	and	CCONJ
admet-995	129	38	value	value	NOUN
admet-995	129	39	ranges	range	NOUN
admet-995	129	40	were	be	AUX
admet-995	129	41	excluded	exclude	VERB
admet-995	129	42	.	.	PUNCT
admet-995	130	1	in	in	ADP
admet-995	130	2	cases	case	NOUN
admet-995	130	3	of	of	ADP
admet-995	130	4	differences	difference	NOUN
admet-995	130	5	in	in	ADP
admet-995	130	6	the	the	DET
admet-995	130	7	reported	report	VERB
admet-995	130	8	data	datum	NOUN
admet-995	130	9	for	for	ADP
admet-995	130	10	the	the	DET
admet-995	130	11	same	same	ADJ
admet-995	130	12	compound	compound	NOUN
admet-995	130	13	,	,	PUNCT
admet-995	130	14	mean	mean	VERB
admet-995	130	15	values	value	NOUN
admet-995	130	16	were	be	AUX
admet-995	130	17	calculated	calculate	VERB
admet-995	130	18	and	and	CCONJ
admet-995	130	19	considered	consider	VERB
admet-995	130	20	for	for	ADP
admet-995	130	21	the	the	DET
admet-995	130	22	model	model	NOUN
admet-995	130	23	building	building	NOUN
admet-995	130	24	while	while	SCONJ
admet-995	130	25	outlier	outlier	ADJ
admet-995	130	26	values	value	NOUN
admet-995	130	27	were	be	AUX
admet-995	130	28	omitted	omit	VERB
admet-995	130	29	when	when	SCONJ
admet-995	130	30	the	the	DET
admet-995	130	31	deviation	deviation	NOUN
admet-995	130	32	in	in	ADP
admet-995	130	33	the	the	DET
admet-995	130	34	results	result	NOUN
admet-995	130	35	was	be	AUX
admet-995	130	36	significant	significant	ADJ
admet-995	130	37	(	(	PUNCT
admet-995	130	38	data	datum	NOUN
admet-995	130	39	points	point	NOUN
admet-995	130	40	not	not	PART
admet-995	130	41	falling	fall	VERB
admet-995	130	42	within	within	ADP
admet-995	130	43	three	three	NUM
admet-995	130	44	standard	standard	ADJ
admet-995	130	45	deviations	deviation	NOUN
admet-995	130	46	of	of	ADP
admet-995	130	47	the	the	DET
admet-995	130	48	mean	mean	NOUN
admet-995	130	49	)	)	PUNCT
admet-995	130	50	.	.	PUNCT
admet-995	131	1	compound	compound	NOUN
admet-995	131	2	chi	chi	PROPN
admet-995	131	3	iam	iam	PROPN
admet-995	131	4	octanophenone	octanophenone	VERB
admet-995	131	5	49.4	49.4	NUM
admet-995	131	6	heptanophenone	heptanophenone	NOUN
admet-995	131	7	45.7	45.7	NUM
admet-995	131	8	hexanophenone	hexanophenone	NOUN
admet-995	131	9	41.8	41.8	NUM
admet-995	131	10	valerophenone	valerophenone	NOUN
admet-995	131	11	37.3	37.3	NUM
admet-995	131	12	butyrophenone	butyrophenone	NOUN
admet-995	131	13	32.0	32.0	NUM
admet-995	131	14	propiophenone	propiophenone	NOUN
admet-995	131	15	25.9	25.9	NUM
admet-995	131	16	acetophenone	acetophenone	NOUN
admet-995	131	17	17.2	17.2	NUM
admet-995	131	18	acetanilide	acetanilide	ADJ
admet-995	131	19	11.5	11.5	NUM
admet-995	131	20	paracetamol	paracetamol	NOUN
admet-995	131	21	2.9	2.9	NUM
admet-995	131	22	http://dx.doi.org/10.5599/admet.0000	http://dx.doi.org/10.5599/admet.0000	NUM
admet-995	131	23	https://drugdesign.riken.jp/hergdb/	https://drugdesign.riken.jp/hergdb/	NOUN
admet-995	131	24	stergiopoulos	stergiopoulo	NOUN
admet-995	131	25	,	,	PUNCT
admet-995	131	26	tsopelas	tsopela	NOUN
admet-995	131	27	and	and	CCONJ
admet-995	131	28	valko	valko	PROPN
admet-995	131	29	admet	admet	PROPN
admet-995	131	30	&	&	CCONJ
admet-995	131	31	dmpk	dmpk	PROPN
admet-995	131	32	9(3	9(3	NUM
admet-995	131	33	)	)	PUNCT
admet-995	131	34	(	(	PUNCT
admet-995	131	35	2021	2021	NUM
admet-995	131	36	)	)	PUNCT
admet-995	131	37	191	191	NUM
admet-995	131	38	-	-	SYM
admet-995	131	39	207	207	NUM
admet-995	131	40	196	196	NUM
admet-995	131	41	calculated	calculate	VERB
admet-995	131	42	physicochemical	physicochemical	ADJ
admet-995	131	43	properties	property	NOUN
admet-995	131	44	adme	adme	NOUN
admet-995	131	45	boxes	box	VERB
admet-995	131	46	v.3.0	v.3.0	ADJ
admet-995	131	47	software	software	NOUN
admet-995	131	48	(	(	PUNCT
admet-995	131	49	pharma	pharma	PROPN
admet-995	131	50	algorithm	algorithm	PROPN
admet-995	131	51	)	)	PUNCT
admet-995	131	52	was	be	AUX
admet-995	131	53	used	use	VERB
admet-995	131	54	to	to	PART
admet-995	131	55	calculate	calculate	VERB
admet-995	131	56	various	various	ADJ
admet-995	131	57	physicochemical	physicochemical	ADJ
admet-995	131	58	parameters	parameter	NOUN
admet-995	131	59	of	of	ADP
admet-995	131	60	the	the	DET
admet-995	131	61	investigated	investigate	VERB
admet-995	131	62	compounds	compound	NOUN
admet-995	131	63	such	such	ADJ
admet-995	131	64	as	as	ADP
admet-995	131	65	octanol	octanol	NOUN
admet-995	131	66	-	-	PUNCT
admet-995	131	67	water	water	NOUN
admet-995	131	68	partition	partition	NOUN
admet-995	131	69	(	(	PUNCT
admet-995	131	70	log	log	VERB
admet-995	131	71	p	p	X
admet-995	131	72	)	)	PUNCT
admet-995	131	73	and	and	CCONJ
admet-995	131	74	distribution	distribution	NOUN
admet-995	131	75	(	(	PUNCT
admet-995	131	76	log	log	NOUN
admet-995	131	77	d	d	NOUN
admet-995	131	78	)	)	PUNCT
admet-995	131	79	coefficients	coefficient	NOUN
admet-995	131	80	at	at	ADP
admet-995	131	81	the	the	DET
admet-995	131	82	ph	ph	ADJ
admet-995	131	83	values	value	NOUN
admet-995	131	84	of	of	ADP
admet-995	131	85	7.4	7.4	NUM
admet-995	131	86	,	,	PUNCT
admet-995	131	87	hydrogen	hydrogen	NOUN
admet-995	131	88	bond	bond	NOUN
admet-995	131	89	donor	donor	NOUN
admet-995	131	90	(	(	PUNCT
admet-995	131	91	hbd	hbd	NOUN
admet-995	131	92	)	)	PUNCT
admet-995	131	93	and	and	CCONJ
admet-995	131	94	acceptor	acceptor	NOUN
admet-995	131	95	(	(	PUNCT
admet-995	131	96	hba	hba	NOUN
admet-995	131	97	)	)	PUNCT
admet-995	131	98	groups	group	NOUN
admet-995	131	99	,	,	PUNCT
admet-995	131	100	abraham	abraham	PROPN
admet-995	131	101	's	's	PART
admet-995	131	102	hydrogen	hydrogen	NOUN
admet-995	131	103	bond	bond	NOUN
admet-995	131	104	acidity	acidity	NOUN
admet-995	131	105	(	(	PUNCT
admet-995	131	106	a	a	NOUN
admet-995	131	107	)	)	PUNCT
admet-995	131	108	and	and	CCONJ
admet-995	131	109	basicity	basicity	NOUN
admet-995	131	110	(	(	PUNCT
admet-995	131	111	b	b	NOUN
admet-995	131	112	)	)	PUNCT
admet-995	131	113	,	,	PUNCT
admet-995	131	114	total	total	ADJ
admet-995	131	115	polar	polar	ADJ
admet-995	131	116	surface	surface	NOUN
admet-995	131	117	area	area	NOUN
admet-995	131	118	(	(	PUNCT
admet-995	131	119	tpsa	tpsa	PROPN
admet-995	131	120	)	)	PUNCT
admet-995	131	121	,	,	PUNCT
admet-995	132	1	molecular	molecular	ADJ
admet-995	132	2	weight	weight	NOUN
admet-995	132	3	(	(	PUNCT
admet-995	132	4	mw	mw	NOUN
admet-995	132	5	)	)	PUNCT
admet-995	132	6	,	,	PUNCT
admet-995	132	7	as	as	ADV
admet-995	132	8	well	well	ADV
admet-995	132	9	as	as	ADP
admet-995	132	10	the	the	DET
admet-995	132	11	molecular	molecular	ADJ
admet-995	132	12	fractions	fraction	NOUN
admet-995	132	13	of	of	ADP
admet-995	132	14	positively	positively	ADV
admet-995	132	15	charged	charge	VERB
admet-995	132	16	(	(	PUNCT
admet-995	132	17	f+	f+	PROPN
admet-995	132	18	)	)	PUNCT
admet-995	132	19	,	,	PUNCT
admet-995	132	20	negatively	negatively	ADV
admet-995	132	21	charged	charge	VERB
admet-995	132	22	(	(	PUNCT
admet-995	132	23	f-	f-	X
admet-995	132	24	)	)	PUNCT
admet-995	132	25	and	and	CCONJ
admet-995	132	26	zwitterionic	zwitterionic	ADJ
admet-995	132	27	species	specie	NOUN
admet-995	132	28	(	(	PUNCT
admet-995	132	29	fz	fz	NOUN
admet-995	132	30	)	)	PUNCT
admet-995	132	31	at	at	ADP
admet-995	132	32	ph	ph	ADJ
admet-995	132	33	=	=	NOUN
admet-995	132	34	7.4	7.4	NUM
admet-995	132	35	.	.	PUNCT
admet-995	132	36	statistical	statistical	ADJ
admet-995	132	37	and	and	CCONJ
admet-995	132	38	visualisation	visualisation	NOUN
admet-995	132	39	software	software	NOUN
admet-995	132	40	jmp	jmp	PROPN
admet-995	132	41	v13.0	v13.0	PROPN
admet-995	132	42	(	(	PUNCT
admet-995	132	43	sas	sas	PROPN
admet-995	132	44	institute	institute	PROPN
admet-995	132	45	inc	inc	PROPN
admet-995	132	46	)	)	PUNCT
admet-995	132	47	and	and	CCONJ
admet-995	132	48	spss	spss	PROPN
admet-995	132	49	23.0	23.0	NUM
admet-995	132	50	(	(	PUNCT
admet-995	132	51	ibm	ibm	PROPN
admet-995	132	52	spss	spss	PROPN
admet-995	132	53	statistics	statistic	NOUN
admet-995	132	54	)	)	PUNCT
admet-995	132	55	were	be	AUX
admet-995	132	56	used	use	VERB
admet-995	132	57	for	for	ADP
admet-995	132	58	the	the	DET
admet-995	132	59	statistical	statistical	ADJ
admet-995	132	60	calculations	calculation	NOUN
admet-995	132	61	and	and	CCONJ
admet-995	132	62	the	the	DET
admet-995	132	63	stepwise	stepwise	PROPN
admet-995	132	64	regression	regression	NOUN
admet-995	132	65	analysis	analysis	NOUN
admet-995	132	66	.	.	PUNCT
admet-995	133	1	for	for	ADP
admet-995	133	2	visualisation	visualisation	NOUN
admet-995	133	3	,	,	PUNCT
admet-995	133	4	stardrop	stardrop	NOUN
admet-995	133	5	(	(	PUNCT
admet-995	133	6	optibrium	optibrium	PROPN
admet-995	133	7	ltd	ltd	PROPN
admet-995	133	8	)	)	PUNCT
admet-995	133	9	chemically	chemically	ADV
admet-995	133	10	aware	aware	ADJ
admet-995	133	11	visualisation	visualisation	NOUN
admet-995	133	12	tools	tool	NOUN
admet-995	133	13	were	be	AUX
admet-995	133	14	used	use	VERB
admet-995	133	15	to	to	PART
admet-995	133	16	create	create	VERB
admet-995	133	17	the	the	DET
admet-995	133	18	plots	plot	NOUN
admet-995	133	19	.	.	PUNCT
admet-995	134	1	results	result	NOUN
admet-995	134	2	and	and	CCONJ
admet-995	134	3	discussion	discussion	NOUN
admet-995	134	4	table	table	NOUN
admet-995	134	5	4	4	NUM
admet-995	134	6	contains	contain	VERB
admet-995	134	7	the	the	DET
admet-995	134	8	collected	collect	VERB
admet-995	134	9	and	and	CCONJ
admet-995	134	10	quality	quality	NOUN
admet-995	134	11	checked	check	VERB
admet-995	134	12	pic50	pic50	ADJ
admet-995	134	13	data	datum	NOUN
admet-995	134	14	of	of	ADP
admet-995	134	15	the	the	DET
admet-995	134	16	investigated	investigate	VERB
admet-995	134	17	90	90	NUM
admet-995	134	18	drug	drug	NOUN
admet-995	134	19	molecules	molecule	NOUN
admet-995	134	20	with	with	ADP
admet-995	134	21	their	their	PRON
admet-995	134	22	generic	generic	ADJ
admet-995	134	23	names	name	NOUN
admet-995	134	24	and	and	CCONJ
admet-995	134	25	the	the	DET
admet-995	134	26	measured	measure	VERB
admet-995	134	27	biomimetic	biomimetic	ADJ
admet-995	134	28	hplc	hplc	NOUN
admet-995	134	29	data	datum	NOUN
admet-995	134	30	.	.	PUNCT
admet-995	135	1	the	the	DET
admet-995	135	2	drugs	drug	NOUN
admet-995	135	3	used	use	VERB
admet-995	135	4	in	in	ADP
admet-995	135	5	the	the	DET
admet-995	135	6	training	training	NOUN
admet-995	135	7	set	set	NOUN
admet-995	135	8	and	and	CCONJ
admet-995	135	9	test	test	NOUN
admet-995	135	10	set	set	VERB
admet-995	135	11	are	be	AUX
admet-995	135	12	listed	list	VERB
admet-995	135	13	separately	separately	ADV
admet-995	135	14	in	in	ADP
admet-995	135	15	alphabetical	alphabetical	ADJ
admet-995	135	16	order	order	NOUN
admet-995	135	17	.	.	PUNCT
admet-995	136	1	table	table	NOUN
admet-995	136	2	4	4	NUM
admet-995	136	3	.	.	PUNCT
admet-995	137	1	the	the	DET
admet-995	137	2	investigated	investigate	VERB
admet-995	137	3	marketed	market	VERB
admet-995	137	4	drugs	drug	NOUN
admet-995	137	5	,	,	PUNCT
admet-995	137	6	their	their	PRON
admet-995	137	7	herg	herg	PROPN
admet-995	137	8	pic50	pic50	ADJ
admet-995	137	9	values	value	NOUN
admet-995	137	10	and	and	CCONJ
admet-995	137	11	the	the	DET
admet-995	137	12	measured	measure	VERB
admet-995	137	13	biomimetic	biomimetic	ADJ
admet-995	137	14	lipophilicity	lipophilicity	NOUN
admet-995	137	15	chi	chi	NOUN
admet-995	137	16	log	log	VERB
admet-995	137	17	d	d	NOUN
admet-995	137	18	at	at	ADP
admet-995	137	19	ph	ph	PROPN
admet-995	137	20	7.4	7.4	NUM
admet-995	137	21	,	,	PUNCT
admet-995	137	22	chi	chi	NOUN
admet-995	137	23	log	log	VERB
admet-995	137	24	p	p	NOUN
admet-995	137	25	,	,	PUNCT
admet-995	137	26	protein	protein	NOUN
admet-995	137	27	binding	bind	VERB
admet-995	137	28	(	(	PUNCT
admet-995	137	29	log	log	PROPN
admet-995	137	30	k	k	PROPN
admet-995	137	31	hsa	hsa	PROPN
admet-995	137	32	and	and	CCONJ
admet-995	137	33	log	log	VERB
admet-995	137	34	k	k	PROPN
admet-995	137	35	agp	agp	PROPN
admet-995	137	36	)	)	PUNCT
admet-995	137	37	and	and	CCONJ
admet-995	137	38	phospholipid	phospholipid	NOUN
admet-995	137	39	partition	partition	NOUN
admet-995	137	40	(	(	PUNCT
admet-995	137	41	log	log	NOUN
admet-995	137	42	k	k	PROPN
admet-995	137	43	iam	iam	PROPN
admet-995	137	44	)	)	PUNCT
admet-995	137	45	.	.	PUNCT
admet-995	138	1	the	the	DET
admet-995	138	2	test	test	NOUN
admet-995	138	3	set	set	NOUN
admet-995	138	4	of	of	ADP
admet-995	138	5	compounds	compound	NOUN
admet-995	138	6	are	be	AUX
admet-995	138	7	listed	list	VERB
admet-995	138	8	in	in	ADP
admet-995	138	9	the	the	DET
admet-995	138	10	second	second	ADJ
admet-995	138	11	part	part	NOUN
admet-995	138	12	of	of	ADP
admet-995	138	13	the	the	DET
admet-995	138	14	table	table	NOUN
admet-995	138	15	in	in	ADP
admet-995	138	16	bold	bold	ADJ
admet-995	138	17	.	.	PUNCT
admet-995	139	1	drug	drug	NOUN
admet-995	139	2	pic50	pic50	PROPN
admet-995	139	3	chi	chi	NOUN
admet-995	139	4	log	log	NOUN
admet-995	139	5	d7.4	d7.4	NOUN
admet-995	139	6	chi	chi	NOUN
admet-995	139	7	log	log	VERB
admet-995	139	8	p	p	NOUN
admet-995	139	9	log	log	NOUN
admet-995	140	1	k	k	PROPN
admet-995	140	2	hsa	hsa	PROPN
admet-995	140	3	log	log	NOUN
admet-995	140	4	k	k	PROPN
admet-995	140	5	agp	agp	PROPN
admet-995	140	6	chi	chi	PROPN
admet-995	140	7	iam	iam	PROPN
admet-995	140	8	log	log	VERB
admet-995	140	9	k	k	PROPN
admet-995	140	10	iam	iam	PROPN
admet-995	140	11	charge	charge	VERB
admet-995	140	12	amitriptyline	amitriptyline	NOUN
admet-995	140	13	5.10	5.10	NUM
admet-995	140	14	2.65	2.65	NUM
admet-995	140	15	5.21	5.21	NUM
admet-995	140	16	0.91	0.91	NUM
admet-995	140	17	1.05	1.05	NUM
admet-995	140	18	55.27	55.27	NUM
admet-995	140	19	2.96	2.96	NUM
admet-995	140	20	basic	basic	ADJ
admet-995	140	21	apomorphine	apomorphine	NOUN
admet-995	140	22	5.59	5.59	NUM
admet-995	140	23	1.17	1.17	NUM
admet-995	140	24	2.66	2.66	NUM
admet-995	140	25	1.04	1.04	NUM
admet-995	140	26	0.83	0.83	NUM
admet-995	140	27	39.67	39.67	NUM
admet-995	140	28	2.24	2.24	NUM
admet-995	140	29	weak	weak	ADJ
admet-995	140	30	base	base	NOUN
admet-995	140	31	astemizole	astemizole	NOUN
admet-995	140	32	6.69	6.69	NUM
admet-995	140	33	2.68	2.68	NUM
admet-995	140	34	3.52	3.52	NUM
admet-995	140	35	1.17	1.17	NUM
admet-995	140	36	1.12	1.12	NUM
admet-995	140	37	51.07	51.07	NUM
admet-995	140	38	2.77	2.77	NUM
admet-995	140	39	basic	basic	ADJ
admet-995	140	40	atenolol	atenolol	NOUN
admet-995	140	41	3.00	3.00	NUM
admet-995	140	42	-0.40	-0.40	NUM
admet-995	140	43	0.64	0.64	NUM
admet-995	140	44	-1.08	-1.08	NUM
admet-995	140	45	-1.83	-1.83	NUM
admet-995	140	46	15.75	15.75	NUM
admet-995	140	47	1.14	1.14	NUM
admet-995	140	48	basic	basic	ADJ
admet-995	140	49	bepridil	bepridil	NOUN
admet-995	140	50	6.42	6.42	NUM
admet-995	140	51	4.40	4.40	NUM
admet-995	140	52	6.62	6.62	NUM
admet-995	140	53	1.27	1.27	NUM
admet-995	140	54	1.14	1.14	NUM
admet-995	140	55	57.73	57.73	NUM
admet-995	140	56	3.08	3.08	NUM
admet-995	140	57	basic	basic	ADJ
admet-995	140	58	brompheniramine	brompheniramine	NOUN
admet-995	140	59	5.61	5.61	NUM
admet-995	140	60	1.74	1.74	NUM
admet-995	140	61	4.27	4.27	NUM
admet-995	140	62	0.68	0.68	NUM
admet-995	140	63	0.68	0.68	NUM
admet-995	140	64	51.69	51.69	NUM
admet-995	140	65	2.8	2.8	NUM
admet-995	140	66	basic	basic	ADJ
admet-995	140	67	bupivacaine	bupivacaine	NOUN
admet-995	140	68	5.51	5.51	NUM
admet-995	140	69	3.06	3.06	NUM
admet-995	140	70	3.97	3.97	NUM
admet-995	140	71	-0.10	-0.10	NUM
admet-995	140	72	1.35	1.35	NUM
admet-995	140	73	41.66	41.66	NUM
admet-995	140	74	2.34	2.34	NUM
admet-995	140	75	weak	weak	ADJ
admet-995	140	76	base	base	NOUN
admet-995	140	77	carbamazepine	carbamazepine	NOUN
admet-995	140	78	3.98	3.98	NUM
admet-995	140	79	1.22	1.22	NUM
admet-995	140	80	1.33	1.33	NUM
admet-995	140	81	0.07	0.07	NUM
admet-995	140	82	-0.85	-0.85	NOUN
admet-995	140	83	23.98	23.98	NUM
admet-995	140	84	1.53	1.53	NUM
admet-995	140	85	neutral	neutral	ADJ
admet-995	140	86	cetirizine	cetirizine	NOUN
admet-995	140	87	4.65	4.65	NUM
admet-995	140	88	1.63	1.63	NUM
admet-995	140	89	2.04	2.04	NUM
admet-995	140	90	0.85	0.85	NUM
admet-995	140	91	0.23	0.23	NUM
admet-995	140	92	40.56	40.56	NUM
admet-995	140	93	2.29	2.29	NUM
admet-995	140	94	zwitterionic	zwitterionic	ADJ
admet-995	140	95	chloroquine	chloroquine	NOUN
admet-995	140	96	5.03	5.03	NUM
admet-995	140	97	1.18	1.18	NUM
admet-995	140	98	2.68	2.68	NUM
admet-995	140	99	0.70	0.70	NUM
admet-995	140	100	1.12	1.12	NUM
admet-995	140	101	43.99	43.99	NUM
admet-995	140	102	2.40	2.40	NUM
admet-995	140	103	basic	basic	ADJ
admet-995	140	104	chlorpromazine	chlorpromazine	NOUN
admet-995	140	105	5.65	5.65	NUM
admet-995	140	106	-0.58	-0.58	NUM
admet-995	140	107	0.97	0.97	NUM
admet-995	140	108	1.35	1.35	NUM
admet-995	140	109	1.79	1.79	NUM
admet-995	140	110	48.16	48.16	NUM
admet-995	140	111	2.64	2.64	NUM
admet-995	140	112	basic	basic	ADJ
admet-995	140	113	ciprofloxacin	ciprofloxacin	NOUN
admet-995	140	114	3.02	3.02	NUM
admet-995	140	115	-0.09	-0.09	NUM
admet-995	140	116	0.05	0.05	NUM
admet-995	140	117	-0.54	-0.54	NOUN
admet-995	140	118	-1.19	-1.19	ADP
admet-995	140	119	25.39	25.39	NUM
admet-995	140	120	1.59	1.59	NUM
admet-995	140	121	zwitterionic	zwitterionic	ADJ
admet-995	140	122	cisapride	cisapride	NOUN
admet-995	140	123	6.88	6.88	NUM
admet-995	140	124	2.65	2.65	NUM
admet-995	140	125	3.17	3.17	NUM
admet-995	140	126	1.11	1.11	NUM
admet-995	140	127	0.84	0.84	NUM
admet-995	140	128	41.85	41.85	NUM
admet-995	140	129	2.35	2.35	NUM
admet-995	140	130	basic	basic	ADJ
admet-995	140	131	citalopram	citalopram	PROPN
admet-995	140	132	5.27	5.27	NUM
admet-995	140	133	1.59	1.59	NUM
admet-995	140	134	4.32	4.32	NUM
admet-995	140	135	0.40	0.40	NUM
admet-995	140	136	0.44	0.44	NUM
admet-995	140	137	48.80	48.80	NUM
admet-995	140	138	2.66	2.66	NUM
admet-995	140	139	basic	basic	ADJ
admet-995	140	140	clarithromycin	clarithromycin	PROPN
admet-995	140	141	4.32	4.32	NUM
admet-995	140	142	1.9	1.9	NUM
admet-995	140	143	4.55	4.55	NUM
admet-995	140	144	-0.24	-0.24	NUM
admet-995	140	145	0.20	0.20	NUM
admet-995	140	146	49.68	49.68	NUM
admet-995	140	147	2.70	2.70	NUM
admet-995	140	148	basic	basic	ADJ
admet-995	140	149	clemastine	clemastine	NOUN
admet-995	140	150	6.69	6.69	NUM
admet-995	140	151	3.18	3.18	NUM
admet-995	140	152	3.18	3.18	NUM
admet-995	140	153	1.25	1.25	NUM
admet-995	140	154	1.18	1.18	NUM
admet-995	140	155	60.12	60.12	NUM
admet-995	140	156	3.19	3.19	NUM
admet-995	140	157	basic	basic	ADJ
admet-995	140	158	clozapine	clozapine	NOUN
admet-995	140	159	6.5	6.5	NUM
admet-995	140	160	2.6	2.6	NUM
admet-995	140	161	3.05	3.05	NUM
admet-995	140	162	1.04	1.04	NUM
admet-995	140	163	0.99	0.99	NUM
admet-995	140	164	52.42	52.42	NUM
admet-995	140	165	2.83	2.83	NUM
admet-995	140	166	weak	weak	ADJ
admet-995	140	167	base	base	NOUN
admet-995	140	168	desipramine	desipramine	NOUN
admet-995	140	169	5.36	5.36	NUM
admet-995	140	170	1.84	1.84	NUM
admet-995	140	171	3.49	3.49	NUM
admet-995	140	172	0.76	0.76	NUM
admet-995	140	173	0.94	0.94	NUM
admet-995	140	174	53.10	53.10	NUM
admet-995	140	175	2.86	2.86	NUM
admet-995	140	176	basic	basic	ADJ
admet-995	140	177	diltiazem	diltiazem	NOUN
admet-995	140	178	4.81	4.81	NUM
admet-995	140	179	2.76	2.76	NUM
admet-995	140	180	3.12	3.12	NUM
admet-995	140	181	0.36	0.36	NUM
admet-995	140	182	0.41	0.41	NUM
admet-995	140	183	41.95	41.95	NUM
admet-995	140	184	2.35	2.35	NUM
admet-995	140	185	basic	basic	ADJ
admet-995	140	186	dolasetron	dolasetron	NOUN
admet-995	140	187	4.65	4.65	NUM
admet-995	140	188	1.46	1.46	NUM
admet-995	140	189	1.46	1.46	NUM
admet-995	140	190	0.60	0.60	NUM
admet-995	140	191	0.69	0.69	NUM
admet-995	140	192	33.20	33.20	NUM
admet-995	140	193	1.95	1.95	NUM
admet-995	140	194	weak	weak	ADJ
admet-995	140	195	base	base	NOUN
admet-995	140	196	domperidone	domperidone	NOUN
admet-995	140	197	6.79	6.79	NUM
admet-995	140	198	1.37	1.37	NUM
admet-995	140	199	2.13	2.13	NUM
admet-995	140	200	1.02	1.02	NUM
admet-995	140	201	0.92	0.92	NUM
admet-995	140	202	43.47	43.47	NUM
admet-995	140	203	2.42	2.42	NUM
admet-995	140	204	weak	weak	ADJ
admet-995	140	205	base	base	NOUN
admet-995	140	206	doxazosin	doxazosin	VERB
admet-995	140	207	6.03	6.03	NUM
admet-995	140	208	2.09	2.09	NUM
admet-995	140	209	2.24	2.24	NUM
admet-995	140	210	1.04	1.04	NUM
admet-995	140	211	0.72	0.72	NUM
admet-995	140	212	37.80	37.80	NUM
admet-995	140	213	2.16	2.16	NUM
admet-995	140	214	weak	weak	ADJ
admet-995	140	215	base	base	NOUN
admet-995	140	216	droperidol	droperidol	VERB
admet-995	140	217	6.89	6.89	NUM
admet-995	140	218	2.26	2.26	NUM
admet-995	140	219	2.68	2.68	NUM
admet-995	140	220	0.98	0.98	NUM
admet-995	140	221	1.69	1.69	NUM
admet-995	140	222	39.31	39.31	NUM
admet-995	140	223	2.23	2.23	NUM
admet-995	140	224	weak	weak	ADJ
admet-995	140	225	base	base	NOUN
admet-995	140	226	admet	admet	NOUN
admet-995	140	227	&	&	CCONJ
admet-995	140	228	dmpk	dmpk	PROPN
admet-995	140	229	9(3	9(3	NUM
admet-995	140	230	)	)	PUNCT
admet-995	140	231	(	(	PUNCT
admet-995	140	232	2021	2021	NUM
admet-995	140	233	)	)	PUNCT
admet-995	140	234	191	191	NUM
admet-995	140	235	-	-	SYM
admet-995	140	236	207	207	NUM
admet-995	140	237	prediction	prediction	NOUN
admet-995	140	238	of	of	ADP
admet-995	140	239	herg	herg	PROPN
admet-995	140	240	inhibition	inhibition	NOUN
admet-995	140	241	by	by	ADP
admet-995	140	242	biomimetic	biomimetic	ADJ
admet-995	140	243	measurements	measurement	NOUN
admet-995	140	244	doi	doi	NOUN
admet-995	140	245	:	:	PUNCT
admet-995	140	246	http://dx.doi.org/10.5599/admet.995	http://dx.doi.org/10.5599/admet.995	ADJ
admet-995	140	247	197	197	NUM
admet-995	140	248	table	table	NOUN
admet-995	140	249	4	4	NUM
admet-995	140	250	.	.	PUNCT
admet-995	140	251	cont’d	cont’d	NOUN
admet-995	140	252	ebastine	ebastine	PROPN
admet-995	140	253	6.27	6.27	NUM
admet-995	140	254	4.96	4.96	NUM
admet-995	140	255	6.54	6.54	NUM
admet-995	140	256	1.62	1.62	NUM
admet-995	140	257	1.34	1.34	NUM
admet-995	140	258	58.65	58.65	NUM
admet-995	140	259	3.12	3.12	NUM
admet-995	140	260	basic	basic	ADJ
admet-995	140	261	erythromycin	erythromycin	NOUN
admet-995	140	262	4.43	4.43	NUM
admet-995	140	263	1.31	1.31	NUM
admet-995	140	264	2.60	2.60	NUM
admet-995	140	265	-0.22	-0.22	NUM
admet-995	140	266	0.32	0.32	NUM
admet-995	140	267	38.79	38.79	NUM
admet-995	140	268	2.20	2.20	NUM
admet-995	140	269	basic	basic	ADJ
admet-995	140	270	fexofenadine	fexofenadine	NOUN
admet-995	140	271	4.61	4.61	NUM
admet-995	140	272	1.28	1.28	NUM
admet-995	140	273	1.91	1.91	NUM
admet-995	140	274	0.45	0.45	NUM
admet-995	140	275	0.02	0.02	NUM
admet-995	140	276	32.24	32.24	NUM
admet-995	140	277	1.90	1.90	NUM
admet-995	140	278	zwitterionic	zwitterionic	ADJ
admet-995	140	279	fluvoxamine	fluvoxamine	NOUN
admet-995	140	280	5.2	5.2	NUM
admet-995	140	281	2.01	2.01	NUM
admet-995	140	282	3.34	3.34	NUM
admet-995	140	283	0.4	0.4	NUM
admet-995	140	284	0.59	0.59	NUM
admet-995	140	285	50.22	50.22	NUM
admet-995	140	286	2.73	2.73	NUM
admet-995	140	287	basic	basic	ADJ
admet-995	140	288	glibenclamide	glibenclamide	ADJ
admet-995	140	289	4.29	4.29	NUM
admet-995	140	290	2.07	2.07	NUM
admet-995	140	291	3.17	3.17	NUM
admet-995	140	292	1.52	1.52	NUM
admet-995	140	293	0.39	0.39	NUM
admet-995	140	294	32.63	32.63	NUM
admet-995	140	295	1.93	1.93	NUM
admet-995	140	296	acidic	acidic	ADJ
admet-995	140	297	glimepiride	glimepiride	NOUN
admet-995	140	298	4.13	4.13	NUM
admet-995	140	299	2.42	2.42	NUM
admet-995	140	300	3.25	3.25	NUM
admet-995	140	301	1.50	1.50	NUM
admet-995	140	302	0.40	0.40	NUM
admet-995	140	303	30.76	30.76	NUM
admet-995	140	304	1.83	1.83	NUM
admet-995	140	305	basic	basic	ADJ
admet-995	140	306	granisetron	granisetron	ADJ
admet-995	140	307	4.65	4.65	NUM
admet-995	140	308	0.79	0.79	NUM
admet-995	140	309	2.50	2.50	NUM
admet-995	140	310	0.34	0.34	NUM
admet-995	140	311	0.52	0.52	NUM
admet-995	140	312	45.95	45.95	NUM
admet-995	140	313	2.53	2.53	NUM
admet-995	140	314	basic	basic	ADJ
admet-995	140	315	imipramine	imipramine	NOUN
admet-995	140	316	5.40	5.40	NUM
admet-995	140	317	2.05	2.05	NUM
admet-995	140	318	4.60	4.60	NUM
admet-995	140	319	0.95	0.95	NUM
admet-995	140	320	0.96	0.96	NUM
admet-995	140	321	39.44	39.44	NUM
admet-995	140	322	2.23	2.23	NUM
admet-995	140	323	basic	basic	ADJ
admet-995	140	324	isradipine	isradipine	NOUN
admet-995	140	325	5.71	5.71	NUM
admet-995	140	326	3.25	3.25	NUM
admet-995	140	327	3.29	3.29	NUM
admet-995	140	328	1.19	1.19	NUM
admet-995	140	329	1.32	1.32	NUM
admet-995	140	330	38.76	38.76	NUM
admet-995	140	331	2.21	2.21	NUM
admet-995	140	332	neutral	neutral	ADJ
admet-995	140	333	ketoconazole	ketoconazole	NOUN
admet-995	140	334	5.49	5.49	NUM
admet-995	140	335	2.66	2.66	NUM
admet-995	140	336	2.84	2.84	NUM
admet-995	140	337	1.18	1.18	NUM
admet-995	140	338	0.75	0.75	NUM
admet-995	140	339	37.86	37.86	NUM
admet-995	140	340	2.16	2.16	NUM
admet-995	140	341	weak	weak	ADJ
admet-995	140	342	base	base	NOUN
admet-995	140	343	levobupivacaine	levobupivacaine	NOUN
admet-995	140	344	5.48	5.48	NUM
admet-995	140	345	3.25	3.25	NUM
admet-995	140	346	4.20	4.20	NUM
admet-995	140	347	0.13	0.13	NUM
admet-995	140	348	1.25	1.25	NUM
admet-995	140	349	41.83	41.83	NUM
admet-995	140	350	2.34	2.34	NUM
admet-995	140	351	weak	weak	ADJ
admet-995	140	352	base	base	NOUN
admet-995	140	353	levofloxacin	levofloxacin	NOUN
admet-995	140	354	2.93	2.93	NUM
admet-995	140	355	0.54	0.54	NUM
admet-995	140	356	0.54	0.54	NUM
admet-995	140	357	-0.34	-0.34	NOUN
admet-995	140	358	-0.74	-0.74	VERB
admet-995	140	359	28.55	28.55	NUM
admet-995	140	360	1.73	1.73	NUM
admet-995	140	361	zwitterionic	zwitterionic	ADJ
admet-995	140	362	lidocaine	lidocaine	NOUN
admet-995	140	363	3.58	3.58	NUM
admet-995	140	364	2.65	2.65	NUM
admet-995	140	365	3.01	3.01	NUM
admet-995	140	366	-0.71	-0.71	NOUN
admet-995	140	367	0.17	0.17	NUM
admet-995	140	368	32.38	32.38	NUM
admet-995	140	369	1.91	1.91	NUM
admet-995	140	370	weak	weak	ADJ
admet-995	140	371	base	base	NOUN
admet-995	140	372	lomefloxacin	lomefloxacin	PROPN
admet-995	140	373	3.93	3.93	NUM
admet-995	140	374	-0.14	-0.14	NOUN
admet-995	140	375	-0.14	-0.14	NUM
admet-995	140	376	-0.10	-0.10	NUM
admet-995	140	377	-1.01	-1.01	NUM
admet-995	140	378	37.89	37.89	NUM
admet-995	140	379	2.16	2.16	NUM
admet-995	140	380	zwitterionic	zwitterionic	ADJ
admet-995	140	381	loratadine	loratadine	NOUN
admet-995	140	382	4.90	4.90	NUM
admet-995	140	383	3.86	3.86	NUM
admet-995	140	384	4.25	4.25	NUM
admet-995	140	385	1.38	1.38	NUM
admet-995	140	386	1.34	1.34	NUM
admet-995	140	387	44.30	44.30	NUM
admet-995	140	388	2.46	2.46	NUM
admet-995	140	389	weak	weak	ADJ
admet-995	140	390	base	base	NOUN
admet-995	140	391	lovastatin	lovastatin	NOUN
admet-995	140	392	5.16	5.16	NUM
admet-995	140	393	4.09	4.09	NUM
admet-995	140	394	4.24	4.24	NUM
admet-995	140	395	1.24	1.24	NUM
admet-995	140	396	0.87	0.87	NUM
admet-995	140	397	44.38	44.38	NUM
admet-995	140	398	2.46	2.46	NUM
admet-995	140	399	neutral	neutral	ADJ
admet-995	140	400	maprotiline	maprotiline	VERB
admet-995	140	401	5.17	5.17	NUM
admet-995	140	402	2.03	2.03	NUM
admet-995	140	403	4.79	4.79	NUM
admet-995	140	404	0.77	0.77	NUM
admet-995	140	405	0.99	0.99	NUM
admet-995	140	406	56.73	56.73	NUM
admet-995	140	407	3.03	3.03	NUM
admet-995	140	408	basic	basic	ADJ
admet-995	140	409	mefloquine	mefloquine	NOUN
admet-995	140	410	5.45	5.45	NUM
admet-995	140	411	2.18	2.18	NUM
admet-995	140	412	4.22	4.22	NUM
admet-995	140	413	1.38	1.38	NUM
admet-995	140	414	1.11	1.11	NUM
admet-995	140	415	41.65	41.65	NUM
admet-995	140	416	2.29	2.29	NUM
admet-995	140	417	basic	basic	ADJ
admet-995	140	418	metoclopramide	metoclopramide	NOUN
admet-995	140	419	5.27	5.27	NUM
admet-995	140	420	0.5	0.5	NUM
admet-995	140	421	1.91	1.91	NUM
admet-995	140	422	0.15	0.15	NUM
admet-995	140	423	0.23	0.23	NUM
admet-995	140	424	40.38	40.38	NUM
admet-995	140	425	2.28	2.28	NUM
admet-995	140	426	basic	basic	ADJ
admet-995	140	427	mibefradil	mibefradil	NOUN
admet-995	140	428	5.88	5.88	NUM
admet-995	140	429	2.96	2.96	NUM
admet-995	140	430	3.99	3.99	NUM
admet-995	140	431	1.10	1.10	NUM
admet-995	140	432	1.11	1.11	NUM
admet-995	140	433	55.18	55.18	NUM
admet-995	140	434	2.96	2.96	NUM
admet-995	140	435	basic	basic	ADJ
admet-995	140	436	miconazole	miconazole	NOUN
admet-995	140	437	5.68	5.68	NUM
admet-995	140	438	4.64	4.64	NUM
admet-995	140	439	4.70	4.70	NUM
admet-995	140	440	1.54	1.54	NUM
admet-995	140	441	1.26	1.26	NUM
admet-995	140	442	53.72	53.72	NUM
admet-995	140	443	2.89	2.89	NUM
admet-995	140	444	weak	weak	ADJ
admet-995	140	445	base	base	NOUN
admet-995	140	446	moxifloxacin	moxifloxacin	NOUN
admet-995	140	447	3.83	3.83	NUM
admet-995	140	448	0.69	0.69	NUM
admet-995	140	449	0.81	0.81	NUM
admet-995	140	450	0.54	0.54	NUM
admet-995	140	451	-0.46	-0.46	NUM
admet-995	140	452	31.61	31.61	NUM
admet-995	140	453	1.84	1.84	NUM
admet-995	140	454	zwitterionic	zwitterionic	ADJ
admet-995	140	455	nicotine	nicotine	NOUN
admet-995	140	456	3.61	3.61	NUM
admet-995	140	457	0.12	0.12	NUM
admet-995	140	458	1.20	1.20	NUM
admet-995	140	459	-0.03	-0.03	NUM
admet-995	140	460	-0.98	-0.98	NUM
admet-995	140	461	13.79	13.79	NUM
admet-995	140	462	1.05	1.05	NUM
admet-995	140	463	weak	weak	ADJ
admet-995	140	464	base	base	NOUN
admet-995	140	465	nifedipine	nifedipine	NOUN
admet-995	140	466	3.96	3.96	NUM
admet-995	140	467	2.59	2.59	NUM
admet-995	140	468	2.71	2.71	NUM
admet-995	140	469	0.67	0.67	NUM
admet-995	140	470	0.27	0.27	NUM
admet-995	140	471	25.12	25.12	NUM
admet-995	140	472	1.58	1.58	NUM
admet-995	140	473	basic	basic	ADJ
admet-995	140	474	nitrendipine	nitrendipine	NOUN
admet-995	140	475	5.10	5.10	NUM
admet-995	140	476	3.15	3.15	NUM
admet-995	140	477	3.19	3.19	NUM
admet-995	140	478	1.17	1.17	NUM
admet-995	140	479	0.69	0.69	NUM
admet-995	140	480	39.36	39.36	NUM
admet-995	140	481	2.23	2.23	NUM
admet-995	140	482	neutral	neutral	ADJ
admet-995	140	483	ofloxacin	ofloxacin	NOUN
admet-995	140	484	2.93	2.93	NUM
admet-995	140	485	0.53	0.53	NUM
admet-995	140	486	0.53	0.53	NUM
admet-995	140	487	-0.40	-0.40	NOUN
admet-995	140	488	-0.81	-0.81	NUM
admet-995	140	489	26.17	26.17	NUM
admet-995	140	490	1.62	1.62	NUM
admet-995	140	491	zwitterionic	zwitterionic	ADJ
admet-995	140	492	olanzapine	olanzapine	NOUN
admet-995	140	493	5.06	5.06	NUM
admet-995	140	494	1.96	1.96	NUM
admet-995	140	495	2.76	2.76	NUM
admet-995	140	496	0.76	0.76	NUM
admet-995	140	497	0.72	0.72	NUM
admet-995	140	498	49.74	49.74	NUM
admet-995	140	499	2.71	2.71	NUM
admet-995	140	500	weak	weak	ADJ
admet-995	140	501	base	base	NOUN
admet-995	140	502	ondansetron	ondansetron	NOUN
admet-995	140	503	5.73	5.73	NUM
admet-995	140	504	1.33	1.33	NUM
admet-995	140	505	1.66	1.66	NUM
admet-995	140	506	0.54	0.54	NUM
admet-995	140	507	1.30	1.30	NUM
admet-995	140	508	39.01	39.01	NUM
admet-995	140	509	2.22	2.22	NUM
admet-995	140	510	weak	weak	ADJ
admet-995	140	511	base	base	NOUN
admet-995	140	512	pergolide	pergolide	NOUN
admet-995	140	513	6.52	6.52	NUM
admet-995	140	514	2.47	2.47	NUM
admet-995	140	515	3.81	3.81	NUM
admet-995	140	516	0.73	0.73	NUM
admet-995	140	517	1.04	1.04	NUM
admet-995	140	518	52.73	52.73	NUM
admet-995	140	519	2.85	2.85	NUM
admet-995	140	520	basic	basic	ADJ
admet-995	140	521	perphenazine	perphenazine	ADJ
admet-995	140	522	5.88	5.88	NUM
admet-995	140	523	2.92	2.92	NUM
admet-995	140	524	3.50	3.50	NUM
admet-995	140	525	1.39	1.39	NUM
admet-995	140	526	1.13	1.13	NUM
admet-995	140	527	47.64	47.64	NUM
admet-995	140	528	2.61	2.61	NUM
admet-995	140	529	weak	weak	ADJ
admet-995	140	530	base	base	NOUN
admet-995	140	531	phenytoin	phenytoin	NOUN
admet-995	140	532	3.71	3.71	NUM
admet-995	140	533	1.73	1.73	NUM
admet-995	140	534	1.85	1.85	NUM
admet-995	140	535	0.69	0.69	NUM
admet-995	140	536	0.15	0.15	NUM
admet-995	140	537	29.66	29.66	NUM
admet-995	140	538	1.78	1.78	NUM
admet-995	140	539	weak	weak	ADJ
admet-995	140	540	acid	acid	NOUN
admet-995	140	541	pimozide	pimozide	ADJ
admet-995	140	542	6.43	6.43	NUM
admet-995	140	543	3.03	3.03	NUM
admet-995	140	544	3.89	3.89	NUM
admet-995	140	545	1.41	1.41	NUM
admet-995	140	546	1.47	1.47	NUM
admet-995	140	547	52.31	52.31	NUM
admet-995	140	548	2.83	2.83	NUM
admet-995	140	549	weak	weak	ADJ
admet-995	140	550	base	base	NOUN
admet-995	140	551	prazosin	prazosin	NOUN
admet-995	140	552	5.22	5.22	NUM
admet-995	140	553	1.09	1.09	NUM
admet-995	140	554	1.29	1.29	NUM
admet-995	140	555	0.81	0.81	NUM
admet-995	140	556	0.53	0.53	NUM
admet-995	140	557	26.32	26.32	NUM
admet-995	140	558	1.63	1.63	NUM
admet-995	140	559	weak	weak	ADJ
admet-995	140	560	base	base	NOUN
admet-995	140	561	procainamide	procainamide	NOUN
admet-995	140	562	3.86	3.86	NUM
admet-995	140	563	-0.59	-0.59	NUM
admet-995	140	564	0.95	0.95	NUM
admet-995	140	565	-0.71	-0.71	NOUN
admet-995	140	566	-0.54	-0.54	PROPN
admet-995	140	567	19.30	19.30	NUM
admet-995	140	568	1.29	1.29	NUM
admet-995	140	569	basic	basic	ADJ
admet-995	140	570	propafenone	propafenone	NOUN
admet-995	140	571	5.96	5.96	NUM
admet-995	140	572	2.07	2.07	NUM
admet-995	140	573	3.47	3.47	NUM
admet-995	140	574	0.84	0.84	NUM
admet-995	140	575	0.92	0.92	NUM
admet-995	140	576	46.04	46.04	NUM
admet-995	140	577	2.54	2.54	NUM
admet-995	140	578	basic	basic	ADJ
admet-995	140	579	propiverine	propiverine	NOUN
admet-995	140	580	5.22	5.22	NUM
admet-995	140	581	3.84	3.84	NUM
admet-995	140	582	5.05	5.05	NUM
admet-995	140	583	1.01	1.01	NUM
admet-995	140	584	0.94	0.94	NUM
admet-995	140	585	58.60	58.60	NUM
admet-995	140	586	3.12	3.12	NUM
admet-995	140	587	basic	basic	ADJ
admet-995	140	588	propranolol	propranolol	NOUN
admet-995	140	589	5.03	5.03	NUM
admet-995	140	590	1.63	1.63	NUM
admet-995	140	591	3.03	3.03	NUM
admet-995	140	592	0.47	0.47	NUM
admet-995	140	593	0.84	0.84	NUM
admet-995	140	594	42.08	42.08	NUM
admet-995	140	595	2.36	2.36	NUM
admet-995	140	596	basic	basic	ADJ
admet-995	140	597	pyrilamine	pyrilamine	NOUN
admet-995	140	598	5.18	5.18	NUM
admet-995	140	599	1.72	1.72	NUM
admet-995	140	600	3.32	3.32	NUM
admet-995	140	601	0.44	0.44	NUM
admet-995	140	602	0.49	0.49	NUM
admet-995	140	603	46.62	46.62	NUM
admet-995	140	604	2.56	2.56	NUM
admet-995	140	605	basic	basic	ADJ
admet-995	140	606	quetiapine	quetiapine	NOUN
admet-995	140	607	5.21	5.21	NUM
admet-995	140	608	2.55	2.55	NUM
admet-995	140	609	2.69	2.69	NUM
admet-995	140	610	0.92	0.92	NUM
admet-995	140	611	0.97	0.97	NUM
admet-995	140	612	39.38	39.38	NUM
admet-995	140	613	2.23	2.23	NUM
admet-995	140	614	weak	weak	ADJ
admet-995	140	615	base	base	NOUN
admet-995	140	616	quinidine	quinidine	NOUN
admet-995	140	617	5.51	5.51	NUM
admet-995	140	618	1.25	1.25	NUM
admet-995	140	619	2.38	2.38	NUM
admet-995	140	620	0.54	0.54	NUM
admet-995	140	621	0.68	0.68	NUM
admet-995	140	622	49.78	49.78	NUM
admet-995	140	623	2.71	2.71	NUM
admet-995	140	624	basic	basic	ADJ
admet-995	140	625	risperidone	risperidone	NOUN
admet-995	140	626	6.00	6.00	NUM
admet-995	140	627	1.46	1.46	NUM
admet-995	140	628	2.18	2.18	NUM
admet-995	140	629	0.55	0.55	NUM
admet-995	140	630	0.63	0.63	NUM
admet-995	140	631	36.31	36.31	NUM
admet-995	140	632	2.09	2.09	NUM
admet-995	140	633	weak	weak	ADJ
admet-995	140	634	base	base	NOUN
admet-995	140	635	ritonavir	ritonavir	PROPN
admet-995	140	636	5.09	5.09	NUM
admet-995	140	637	3.25	3.25	NUM
admet-995	140	638	3.41	3.41	NUM
admet-995	140	639	1.22	1.22	NUM
admet-995	140	640	0.64	0.64	NUM
admet-995	140	641	38.64	38.64	NUM
admet-995	140	642	2.2	2.2	NUM
admet-995	140	643	neutral	neutral	ADJ
admet-995	140	644	roxithromycin	roxithromycin	NOUN
admet-995	140	645	4.44	4.44	NUM
admet-995	140	646	1.95	1.95	NUM
admet-995	140	647	3.70	3.70	NUM
admet-995	140	648	-0.07	-0.07	NUM
admet-995	140	649	0.60	0.60	NUM
admet-995	140	650	51.33	51.33	NUM
admet-995	140	651	2.78	2.78	NUM
admet-995	140	652	basic	basic	ADJ
admet-995	140	653	saquinavir	saquinavir	NOUN
admet-995	140	654	5.82	5.82	NUM
admet-995	140	655	3.31	3.31	NUM
admet-995	140	656	3.39	3.39	NUM
admet-995	140	657	1.22	1.22	NUM
admet-995	140	658	1.59	1.59	NUM
admet-995	140	659	42.17	42.17	NUM
admet-995	140	660	2.36	2.36	NUM
admet-995	140	661	weak	weak	ADJ
admet-995	140	662	base	base	NOUN
admet-995	140	663	sotalol	sotalol	VERB
admet-995	140	664	3.57	3.57	NUM
admet-995	140	665	-0.39	-0.39	NOUN
admet-995	140	666	-0.35	-0.35	NUM
admet-995	140	667	-0.75	-0.75	NUM
admet-995	140	668	-1.41	-1.41	NUM
admet-995	140	669	21.90	21.90	NUM
admet-995	140	670	1.43	1.43	NUM
admet-995	140	671	basic	basic	ADJ
admet-995	140	672	http://dx.doi.org/10.5599/admet.0000	http://dx.doi.org/10.5599/admet.0000	DET
admet-995	140	673	stergiopoulos	stergiopoulos	PROPN
admet-995	140	674	,	,	PUNCT
admet-995	140	675	tsopelas	tsopela	NOUN
admet-995	140	676	and	and	CCONJ
admet-995	140	677	valko	valko	PROPN
admet-995	140	678	admet	admet	PROPN
admet-995	140	679	&	&	CCONJ
admet-995	140	680	dmpk	dmpk	PROPN
admet-995	140	681	9(3	9(3	NUM
admet-995	140	682	)	)	PUNCT
admet-995	140	683	(	(	PUNCT
admet-995	140	684	2021	2021	NUM
admet-995	140	685	)	)	PUNCT
admet-995	140	686	191	191	NUM
admet-995	140	687	-	-	SYM
admet-995	140	688	207	207	NUM
admet-995	140	689	198	198	NUM
admet-995	140	690	table	table	NOUN
admet-995	140	691	4	4	NUM
admet-995	140	692	.	.	PUNCT
admet-995	140	693	cont’d	cont’d	NOUN
admet-995	140	694	sulfamethoxazole	sulfamethoxazole	NOUN
admet-995	140	695	2.66	2.66	NUM
admet-995	140	696	-0.42	-0.42	NUM
admet-995	140	697	1.03	1.03	NUM
admet-995	140	698	0.4	0.4	NUM
admet-995	140	699	-1.57	-1.57	NUM
admet-995	140	700	13.19	13.19	NUM
admet-995	140	701	1.01	1.01	NUM
admet-995	140	702	acidic	acidic	ADJ
admet-995	140	703	tamsulosin	tamsulosin	NOUN
admet-995	140	704	4.89	4.89	NUM
admet-995	140	705	1.43	1.43	NUM
admet-995	140	706	2.01	2.01	NUM
admet-995	140	707	0.36	0.36	NUM
admet-995	140	708	0.60	0.60	NUM
admet-995	140	709	34.32	34.32	NUM
admet-995	140	710	2.00	2.00	NUM
admet-995	140	711	basic	basic	ADJ
admet-995	140	712	thioridazine	thioridazine	NOUN
admet-995	140	713	6.30	6.30	NUM
admet-995	140	714	3.02	3.02	NUM
admet-995	140	715	5.46	5.46	NUM
admet-995	140	716	1.33	1.33	NUM
admet-995	140	717	1.30	1.30	NUM
admet-995	140	718	70.24	70.24	NUM
admet-995	140	719	3.65	3.65	NUM
admet-995	140	720	basic	basic	ADJ
admet-995	140	721	tolterodine	tolterodine	NOUN
admet-995	140	722	6.23	6.23	NUM
admet-995	140	723	2.00	2.00	NUM
admet-995	140	724	4.95	4.95	NUM
admet-995	140	725	0.55	0.55	NUM
admet-995	140	726	0.79	0.79	NUM
admet-995	140	727	52.45	52.45	NUM
admet-995	140	728	2.83	2.83	NUM
admet-995	140	729	basic	basic	ADJ
admet-995	140	730	trifluoperazine	trifluoperazine	NOUN
admet-995	140	731	5.72	5.72	NUM
admet-995	140	732	3.8	3.8	NUM
admet-995	140	733	5.14	5.14	NUM
admet-995	140	734	1.52	1.52	NUM
admet-995	140	735	1.19	1.19	NUM
admet-995	140	736	68.00	68.00	NUM
admet-995	140	737	3.55	3.55	NUM
admet-995	140	738	basic	basic	ADJ
admet-995	140	739	verapamil	verapamil	NOUN
admet-995	140	740	5.95	5.95	NUM
admet-995	140	741	2.66	2.66	NUM
admet-995	140	742	3.82	3.82	NUM
admet-995	140	743	1.00	1.00	NUM
admet-995	140	744	0.58	0.58	NUM
admet-995	140	745	44.82	44.82	NUM
admet-995	140	746	2.48	2.48	NUM
admet-995	140	747	basic	basic	ADJ
admet-995	140	748	alfuzosin	alfuzosin	NOUN
admet-995	140	749	4.28	4.28	NUM
admet-995	140	750	0.79	0.79	NUM
admet-995	140	751	1.31	1.31	NUM
admet-995	140	752	0.08	0.08	NUM
admet-995	140	753	0.32	0.32	NUM
admet-995	140	754	34.60	34.60	NUM
admet-995	140	755	1.98	1.98	NUM
admet-995	140	756	weak	weak	ADJ
admet-995	140	757	base	base	NOUN
admet-995	140	758	desloratadine	desloratadine	NOUN
admet-995	140	759	5.75	5.75	NUM
admet-995	140	760	1.32	1.32	NUM
admet-995	140	761	4.03	4.03	NUM
admet-995	140	762	0.85	0.85	NUM
admet-995	140	763	1.05	1.05	NUM
admet-995	140	764	54.56	54.56	NUM
admet-995	140	765	2.93	2.93	NUM
admet-995	140	766	basic	basic	ADJ
admet-995	140	767	diphenhydramine	diphenhydramine	NOUN
admet-995	140	768	4.94	4.94	NUM
admet-995	140	769	1.59	1.59	NUM
admet-995	140	770	3.61	3.61	NUM
admet-995	140	771	0.33	0.33	NUM
admet-995	140	772	0.60	0.60	NUM
admet-995	140	773	35.63	35.63	NUM
admet-995	140	774	2.06	2.06	NUM
admet-995	140	775	basic	basic	ADJ
admet-995	140	776	dofetilide	dofetilide	ADJ
admet-995	140	777	5.72	5.72	NUM
admet-995	140	778	1.18	1.18	NUM
admet-995	140	779	1.12	1.12	NUM
admet-995	140	780	-0.05	-0.05	NUM
admet-995	140	781	0.59	0.59	NUM
admet-995	140	782	33.10	33.10	NUM
admet-995	140	783	1.94	1.94	NUM
admet-995	140	784	weak	weak	ADJ
admet-995	140	785	base	base	NOUN
admet-995	140	786	flecainide	flecainide	NOUN
admet-995	140	787	5.25	5.25	NUM
admet-995	140	788	1.68	1.68	NUM
admet-995	140	789	3.01	3.01	NUM
admet-995	140	790	-0.05	-0.05	NUM
admet-995	140	791	0.16	0.16	NUM
admet-995	140	792	41.51	41.51	NUM
admet-995	140	793	2.33	2.33	NUM
admet-995	140	794	basic	basic	ADJ
admet-995	140	795	fluoxetine	fluoxetine	NOUN
admet-995	140	796	5.73	5.73	NUM
admet-995	140	797	2.15	2.15	NUM
admet-995	140	798	3.80	3.80	NUM
admet-995	140	799	0.99	0.99	NUM
admet-995	140	800	0.99	0.99	NUM
admet-995	140	801	54.86	54.86	NUM
admet-995	140	802	2.94	2.94	NUM
admet-995	140	803	basic	basic	ADJ
admet-995	140	804	indomethacin	indomethacin	VERB
admet-995	140	805	3.72	3.72	NUM
admet-995	140	806	1.47	1.47	NUM
admet-995	140	807	3.31	3.31	NUM
admet-995	140	808	1.69	1.69	NUM
admet-995	140	809	0.18	0.18	NUM
admet-995	140	810	30.11	30.11	NUM
admet-995	140	811	1.81	1.81	NUM
admet-995	140	812	acidic	acidic	ADJ
admet-995	140	813	irbesartan	irbesartan	NOUN
admet-995	140	814	4.71	4.71	NUM
admet-995	140	815	1.39	1.39	NUM
admet-995	140	816	2.00	2.00	NUM
admet-995	140	817	1.30	1.30	NUM
admet-995	140	818	1.10	1.10	NUM
admet-995	140	819	26.14	26.14	NUM
admet-995	140	820	1.62	1.62	NUM
admet-995	140	821	zwitterionic	zwitterionic	ADJ
admet-995	140	822	lamotrigine	lamotrigine	NOUN
admet-995	140	823	3.55	3.55	NUM
admet-995	140	824	0.86	0.86	NUM
admet-995	140	825	0.81	0.81	NUM
admet-995	140	826	0.16	0.16	NUM
admet-995	140	827	-0.33	-0.33	NUM
admet-995	140	828	23.25	23.25	NUM
admet-995	140	829	1.49	1.49	NUM
admet-995	140	830	weak	weak	ADJ
admet-995	140	831	base	base	NOUN
admet-995	140	832	metoprolol	metoprolol	NOUN
admet-995	140	833	3.84	3.84	NUM
admet-995	140	834	0.77	0.77	NUM
admet-995	140	835	1.86	1.86	NUM
admet-995	140	836	-0.72	-0.72	NOUN
admet-995	140	837	-0.27	-0.27	NUM
admet-995	140	838	35.38	35.38	NUM
admet-995	140	839	2.05	2.05	NUM
admet-995	140	840	basic	basic	ADJ
admet-995	140	841	protriptyline	protriptyline	NOUN
admet-995	140	842	5.30	5.30	NUM
admet-995	140	843	1.72	1.72	NUM
admet-995	140	844	4.70	4.70	NUM
admet-995	140	845	0.69	0.69	NUM
admet-995	140	846	1.03	1.03	NUM
admet-995	140	847	51.59	51.59	NUM
admet-995	140	848	2.79	2.79	NUM
admet-995	140	849	weak	weak	ADJ
admet-995	140	850	base	base	NOUN
admet-995	140	851	sildenafil	sildenafil	NOUN
admet-995	140	852	4.61	4.61	NUM
admet-995	140	853	2.59	2.59	NUM
admet-995	140	854	2.62	2.62	NUM
admet-995	140	855	0.87	0.87	NUM
admet-995	140	856	0.42	0.42	NUM
admet-995	140	857	35.00	35.00	NUM
admet-995	140	858	2.03	2.03	NUM
admet-995	140	859	weak	weak	ADJ
admet-995	140	860	base	base	NOUN
admet-995	140	861	spironolactone	spironolactone	NOUN
admet-995	140	862	4.64	4.64	NUM
admet-995	140	863	2.76	2.76	NUM
admet-995	140	864	2.97	2.97	NUM
admet-995	140	865	0.78	0.78	NUM
admet-995	140	866	0.50	0.50	NUM
admet-995	140	867	36.93	36.93	NUM
admet-995	140	868	2.12	2.12	NUM
admet-995	140	869	neutral	neutral	ADJ
admet-995	140	870	trazodone	trazodone	NOUN
admet-995	140	871	5.30	5.30	NUM
admet-995	140	872	2.51	2.51	NUM
admet-995	140	873	2.59	2.59	NUM
admet-995	140	874	1.09	1.09	NUM
admet-995	140	875	0.46	0.46	NUM
admet-995	140	876	32.7	32.7	NUM
admet-995	140	877	1.93	1.93	NUM
admet-995	140	878	weak	weak	ADJ
admet-995	140	879	base	base	NOUN
admet-995	140	880	trimethoprim	trimethoprim	NOUN
admet-995	140	881	3.62	3.62	NUM
admet-995	140	882	-1.60	-1.60	NUM
admet-995	140	883	0.42	0.42	NUM
admet-995	140	884	-0.05	-0.05	NUM
admet-995	140	885	-0.07	-0.07	NUM
admet-995	140	886	12.83	12.83	NUM
admet-995	140	887	1.01	1.01	NUM
admet-995	140	888	basic	basic	ADJ
admet-995	140	889	ziprasidone	ziprasidone	NOUN
admet-995	140	890	6.44	6.44	NUM
admet-995	140	891	2.98	2.98	NUM
admet-995	140	892	2.96	2.96	NUM
admet-995	140	893	1.42	1.42	NUM
admet-995	140	894	1.09	1.09	NUM
admet-995	140	895	47.92	47.92	NUM
admet-995	140	896	2.62	2.62	NUM
admet-995	140	897	weak	weak	ADJ
admet-995	140	898	base	base	NOUN
admet-995	140	899	table	table	NOUN
admet-995	140	900	5	5	NUM
admet-995	140	901	contains	contain	VERB
admet-995	140	902	the	the	DET
admet-995	140	903	calculated	calculated	ADJ
admet-995	140	904	physicochemical	physicochemical	ADJ
admet-995	140	905	properties	property	NOUN
admet-995	140	906	of	of	ADP
admet-995	140	907	the	the	DET
admet-995	140	908	investigated	investigate	VERB
admet-995	140	909	compounds	compound	NOUN
admet-995	140	910	.	.	PUNCT
admet-995	141	1	the	the	DET
admet-995	141	2	test	test	NOUN
admet-995	141	3	set	set	NOUN
admet-995	141	4	listed	list	VERB
admet-995	141	5	separately	separately	ADV
admet-995	141	6	in	in	ADP
admet-995	141	7	alphabetical	alphabetical	ADJ
admet-995	141	8	order	order	NOUN
admet-995	141	9	in	in	ADP
admet-995	141	10	the	the	DET
admet-995	141	11	last	last	ADJ
admet-995	141	12	part	part	NOUN
admet-995	141	13	of	of	ADP
admet-995	141	14	the	the	DET
admet-995	141	15	table	table	NOUN
admet-995	141	16	.	.	PUNCT
admet-995	141	17	table	table	NOUN
admet-995	141	18	5	5	NUM
admet-995	141	19	.	.	PUNCT
admet-995	142	1	the	the	DET
admet-995	142	2	calculated	calculate	VERB
admet-995	142	3	physicochemical	physicochemical	ADJ
admet-995	142	4	properties	property	NOUN
admet-995	142	5	of	of	ADP
admet-995	142	6	the	the	DET
admet-995	142	7	compounds	compound	NOUN
admet-995	142	8	.	.	PUNCT
admet-995	143	1	mw	mw	PROPN
admet-995	143	2	is	be	AUX
admet-995	143	3	the	the	DET
admet-995	143	4	molecular	molecular	ADJ
admet-995	143	5	weight	weight	NOUN
admet-995	143	6	,	,	PUNCT
admet-995	143	7	hbd	hbd	NOUN
admet-995	143	8	and	and	CCONJ
admet-995	143	9	hba	hba	NOUN
admet-995	143	10	are	be	AUX
admet-995	143	11	the	the	DET
admet-995	143	12	numbers	number	NOUN
admet-995	143	13	of	of	ADP
admet-995	143	14	h	h	NOUN
admet-995	143	15	-	-	PUNCT
admet-995	143	16	bond	bond	NOUN
admet-995	143	17	donor	donor	NOUN
admet-995	143	18	and	and	CCONJ
admet-995	143	19	acceptor	acceptor	NOUN
admet-995	143	20	groups	group	NOUN
admet-995	143	21	,	,	PUNCT
admet-995	143	22	respectively	respectively	ADV
admet-995	143	23	,	,	PUNCT
admet-995	143	24	tpsa	tpsa	PROPN
admet-995	143	25	is	be	AUX
admet-995	143	26	the	the	DET
admet-995	143	27	topological	topological	ADJ
admet-995	143	28	polar	polar	ADJ
admet-995	143	29	surface	surface	NOUN
admet-995	143	30	area	area	NOUN
admet-995	143	31	,	,	PUNCT
admet-995	143	32	log	log	VERB
admet-995	143	33	p	p	NOUN
admet-995	143	34	and	and	CCONJ
admet-995	143	35	log	log	NOUN
admet-995	144	1	d	d	X
admet-995	144	2	are	be	AUX
admet-995	144	3	the	the	DET
admet-995	144	4	logarithm	logarithm	NOUN
admet-995	144	5	of	of	ADP
admet-995	144	6	the	the	DET
admet-995	144	7	calculated	calculate	VERB
admet-995	144	8	octanol	octanol	NOUN
admet-995	144	9	/	/	SYM
admet-995	144	10	water	water	NOUN
admet-995	144	11	partition	partition	NOUN
admet-995	144	12	coefficient	coefficient	NOUN
admet-995	144	13	of	of	ADP
admet-995	144	14	the	the	DET
admet-995	144	15	neutral	neutral	ADJ
admet-995	144	16	form	form	NOUN
admet-995	144	17	and	and	CCONJ
admet-995	144	18	the	the	DET
admet-995	144	19	combined	combine	VERB
admet-995	144	20	ionised	ionised	ADJ
admet-995	144	21	form	form	NOUN
admet-995	144	22	of	of	ADP
admet-995	144	23	the	the	DET
admet-995	144	24	molecules	molecule	NOUN
admet-995	144	25	at	at	ADP
admet-995	144	26	ph	ph	PROPN
admet-995	144	27	7.4	7.4	NUM
admet-995	144	28	,	,	PUNCT
admet-995	144	29	f+	f+	NUM
admet-995	144	30	,	,	PUNCT
admet-995	144	31	fand	fand	PROPN
admet-995	144	32	fz	fz	PROPN
admet-995	144	33	are	be	AUX
admet-995	144	34	the	the	DET
admet-995	144	35	calculated	calculated	ADJ
admet-995	144	36	fractions	fraction	NOUN
admet-995	144	37	of	of	ADP
admet-995	144	38	the	the	DET
admet-995	144	39	positive	positive	ADJ
admet-995	144	40	,	,	PUNCT
admet-995	144	41	negative	negative	ADJ
admet-995	144	42	and	and	CCONJ
admet-995	144	43	zwitterionic	zwitterionic	ADJ
admet-995	144	44	charges	charge	NOUN
admet-995	144	45	at	at	ADP
admet-995	144	46	physiological	physiological	ADJ
admet-995	144	47	ph	ph	NOUN
admet-995	144	48	(	(	PUNCT
admet-995	144	49	ph	ph	NOUN
admet-995	144	50	7.4	7.4	NUM
admet-995	144	51	)	)	PUNCT
admet-995	144	52	,	,	PUNCT
admet-995	144	53	a	a	PRON
admet-995	144	54	and	and	CCONJ
admet-995	144	55	b	b	NOUN
admet-995	144	56	are	be	AUX
admet-995	144	57	the	the	DET
admet-995	144	58	abraham	abraham	PROPN
admet-995	144	59	h	h	NOUN
admet-995	144	60	-	-	PUNCT
admet-995	144	61	bond	bond	NOUN
admet-995	144	62	acidity	acidity	NOUN
admet-995	144	63	and	and	CCONJ
admet-995	144	64	bbond	bbond	VERB
admet-995	144	65	basicity	basicity	NOUN
admet-995	144	66	parameters	parameter	NOUN
admet-995	144	67	.	.	PUNCT
admet-995	145	1	drug	drug	NOUN
admet-995	145	2	mw	mw	PROPN
admet-995	145	3	hbd	hbd	PROPN
admet-995	145	4	hba	hba	PROPN
admet-995	145	5	tpsa	tpsa	PROPN
admet-995	145	6	log	log	VERB
admet-995	145	7	p	p	NOUN
admet-995	145	8	log	log	NOUN
admet-995	145	9	d	d	NOUN
admet-995	145	10	f+	f+	PROPN
admet-995	145	11	ffz	ffz	VERB
admet-995	145	12	a	a	DET
admet-995	145	13	b	b	NOUN
admet-995	145	14	amitriptyline	amitriptyline	NOUN
admet-995	145	15	277.41	277.41	NUM
admet-995	145	16	0	0	NUM
admet-995	145	17	1	1	NUM
admet-995	145	18	3.2	3.2	NUM
admet-995	145	19	5.04	5.04	NUM
admet-995	145	20	3.70	3.70	NUM
admet-995	145	21	0.98	0.98	NUM
admet-995	145	22	0.00	0.00	NUM
admet-995	145	23	0.00	0.00	NUM
admet-995	145	24	0.00	0.00	NUM
admet-995	145	25	1.00	1.00	NUM
admet-995	145	26	apomorphine	apomorphine	NOUN
admet-995	145	27	267.32	267.32	NUM
admet-995	145	28	2	2	NUM
admet-995	145	29	3	3	NUM
admet-995	145	30	43.7	43.7	NUM
admet-995	145	31	2.49	2.49	NUM
admet-995	145	32	2.16	2.16	NUM
admet-995	145	33	0.62	0.62	NUM
admet-995	145	34	0.00	0.00	NUM
admet-995	145	35	0.02	0.02	NUM
admet-995	145	36	0.77	0.77	NUM
admet-995	145	37	1.10	1.10	NUM
admet-995	145	38	astemizole	astemizole	NOUN
admet-995	145	39	458.57	458.57	NUM
admet-995	145	40	1	1	NUM
admet-995	145	41	5	5	NUM
admet-995	145	42	42.3	42.3	NUM
admet-995	145	43	5.70	5.70	NUM
admet-995	145	44	4.54	4.54	NUM
admet-995	145	45	0.98	0.98	NUM
admet-995	145	46	0.00	0.00	NUM
admet-995	145	47	0.00	0.00	NUM
admet-995	145	48	0.13	0.13	NUM
admet-995	145	49	1.64	1.64	NUM
admet-995	145	50	atenolol	atenolol	NOUN
admet-995	145	51	266.34	266.34	NUM
admet-995	145	52	4	4	NUM
admet-995	145	53	5	5	NUM
admet-995	145	54	84.6	84.6	NUM
admet-995	145	55	0.16	0.16	NUM
admet-995	145	56	-1.89	-1.89	NUM
admet-995	145	57	0.99	0.99	NUM
admet-995	145	58	0.00	0.00	NUM
admet-995	145	59	0.00	0.00	NUM
admet-995	145	60	0.69	0.69	NUM
admet-995	145	61	2.00	2.00	NUM
admet-995	145	62	bepridil	bepridil	NOUN
admet-995	145	63	366.54	366.54	NUM
admet-995	145	64	0	0	NUM
admet-995	145	65	3	3	NUM
admet-995	145	66	15.7	15.7	NUM
admet-995	145	67	6.31	6.31	NUM
admet-995	145	68	4.9	4.9	NUM
admet-995	145	69	0.97	0.97	NUM
admet-995	145	70	0.00	0.00	NUM
admet-995	145	71	0.00	0.00	NUM
admet-995	145	72	0.00	0.00	NUM
admet-995	145	73	1.32	1.32	NUM
admet-995	145	74	brompheniramine	brompheniramine	NOUN
admet-995	145	75	319.24	319.24	NUM
admet-995	145	76	0	0	NUM
admet-995	145	77	2	2	NUM
admet-995	145	78	16.1	16.1	NUM
admet-995	145	79	2.88	2.88	NUM
admet-995	145	80	1.64	1.64	NUM
admet-995	145	81	0.99	0.99	NUM
admet-995	145	82	0.00	0.00	NUM
admet-995	145	83	0.00	0.00	NUM
admet-995	145	84	0.00	0.00	NUM
admet-995	145	85	1.02	1.02	NUM
admet-995	145	86	bupivacaine	bupivacaine	NOUN
admet-995	145	87	288.43	288.43	NUM
admet-995	145	88	1	1	NUM
admet-995	145	89	3	3	NUM
admet-995	145	90	32.3	32.3	NUM
admet-995	145	91	3.41	3.41	NUM
admet-995	145	92	3.73	3.73	NUM
admet-995	145	93	0.78	0.78	NUM
admet-995	145	94	0.00	0.00	NUM
admet-995	145	95	0.00	0.00	NUM
admet-995	145	96	0.26	0.26	NUM
admet-995	145	97	1.19	1.19	NUM
admet-995	145	98	carbamazepine	carbamazepine	NOUN
admet-995	145	99	236.27	236.27	NUM
admet-995	145	100	2	2	NUM
admet-995	145	101	3	3	NUM
admet-995	145	102	46.3	46.3	NUM
admet-995	145	103	2.30	2.30	NUM
admet-995	145	104	2.58	2.58	NUM
admet-995	145	105	0.00	0.00	NUM
admet-995	145	106	0.00	0.00	NUM
admet-995	145	107	0.00	0.00	NUM
admet-995	145	108	0.53	0.53	NUM
admet-995	145	109	1.10	1.10	NUM
admet-995	145	110	cetirizine	cetirizine	NOUN
admet-995	145	111	388.89	388.89	NUM
admet-995	145	112	1	1	NUM
admet-995	145	113	5	5	NUM
admet-995	145	114	53.0	53.0	NUM
admet-995	145	115	1.70	1.70	NUM
admet-995	145	116	0.34	0.34	NUM
admet-995	145	117	0.00	0.00	NUM
admet-995	145	118	0.22	0.22	NUM
admet-995	145	119	0.78	0.78	NUM
admet-995	145	120	0.57	0.57	NUM
admet-995	145	121	1.76	1.76	NUM
admet-995	145	122	chloroquine	chloroquine	NOUN
admet-995	145	123	319.87	319.87	NUM
admet-995	145	124	1	1	NUM
admet-995	145	125	3	3	NUM
admet-995	145	126	28.2	28.2	NUM
admet-995	145	127	4.63	4.63	NUM
admet-995	145	128	2.60	2.60	NUM
admet-995	145	129	1.00	1.00	NUM
admet-995	145	130	0.00	0.00	NUM
admet-995	145	131	0.00	0.00	NUM
admet-995	145	132	0.13	0.13	NUM
admet-995	145	133	1.29	1.29	NUM
admet-995	145	134	chlorpromazine	chlorpromazine	NOUN
admet-995	145	135	318.86	318.86	NUM
admet-995	145	136	0	0	NUM
admet-995	145	137	2	2	NUM
admet-995	145	138	31.8	31.8	NUM
admet-995	145	139	5.35	5.35	NUM
admet-995	145	140	3.34	3.34	NUM
admet-995	145	141	0.99	0.99	NUM
admet-995	145	142	0.00	0.00	NUM
admet-995	145	143	0.00	0.00	NUM
admet-995	145	144	0.00	0.00	NUM
admet-995	145	145	0.94	0.94	NUM
admet-995	145	146	ciprofloxacin	ciprofloxacin	NOUN
admet-995	145	147	331.34	331.34	NUM
admet-995	145	148	2	2	NUM
admet-995	145	149	6	6	NUM
admet-995	145	150	72.9	72.9	NUM
admet-995	145	151	-1.08	-1.08	NUM
admet-995	145	152	-3.03	-3.03	ADJ
admet-995	145	153	0.05	0.05	NUM
admet-995	145	154	0.03	0.03	NUM
admet-995	145	155	0.91	0.91	NUM
admet-995	145	156	0.73	0.73	NUM
admet-995	145	157	1.85	1.85	NUM
admet-995	145	158	cisapride	cisapride	NOUN
admet-995	145	159	465.94	465.94	NUM
admet-995	145	160	3	3	NUM
admet-995	145	161	7	7	NUM
admet-995	145	162	86.1	86.1	NUM
admet-995	145	163	4.20	4.20	NUM
admet-995	145	164	2.49	2.49	NUM
admet-995	145	165	0.98	0.98	NUM
admet-995	145	166	0.00	0.00	NUM
admet-995	145	167	0.00	0.00	NUM
admet-995	145	168	0.50	0.50	NUM
admet-995	145	169	2.17	2.17	NUM
admet-995	145	170	admet	admet	NOUN
admet-995	145	171	&	&	CCONJ
admet-995	145	172	dmpk	dmpk	PROPN
admet-995	145	173	9(3	9(3	NUM
admet-995	145	174	)	)	PUNCT
admet-995	145	175	(	(	PUNCT
admet-995	145	176	2021	2021	NUM
admet-995	145	177	)	)	PUNCT
admet-995	145	178	191	191	NUM
admet-995	145	179	-	-	SYM
admet-995	145	180	207	207	NUM
admet-995	145	181	prediction	prediction	NOUN
admet-995	145	182	of	of	ADP
admet-995	145	183	herg	herg	PROPN
admet-995	145	184	inhibition	inhibition	NOUN
admet-995	145	185	by	by	ADP
admet-995	145	186	biomimetic	biomimetic	ADJ
admet-995	145	187	measurements	measurement	NOUN
admet-995	145	188	doi	doi	NOUN
admet-995	145	189	:	:	PUNCT
admet-995	145	190	http://dx.doi.org/10.5599/admet.995	http://dx.doi.org/10.5599/admet.995	ADJ
admet-995	145	191	199	199	NUM
admet-995	145	192	table	table	NOUN
admet-995	145	193	5	5	NUM
admet-995	145	194	.	.	PUNCT
admet-995	145	195	cont’d	cont’d	NOUN
admet-995	145	196	citalopram	citalopram	PROPN
admet-995	146	1	324.39	324.39	NUM
admet-995	146	2	0	0	NUM
admet-995	146	3	3	3	NUM
admet-995	146	4	36.3	36.3	NUM
admet-995	146	5	3.76	3.76	NUM
admet-995	146	6	0.99	0.99	NUM
admet-995	146	7	0.99	0.99	NUM
admet-995	146	8	0.00	0.00	NUM
admet-995	146	9	0.00	0.00	NUM
admet-995	146	10	0.00	0.00	NUM
admet-995	146	11	1.08	1.08	NUM
admet-995	146	12	clarithromycin	clarithromycin	NOUN
admet-995	146	13	747.95	747.95	NUM
admet-995	146	14	4	4	NUM
admet-995	146	15	14	14	NUM
admet-995	146	16	182.9	182.9	NUM
admet-995	146	17	3.16	3.16	NUM
admet-995	146	18	1.16	1.16	NUM
admet-995	146	19	0.95	0.95	NUM
admet-995	146	20	0.00	0.00	NUM
admet-995	146	21	0.00	0.00	NUM
admet-995	146	22	0.80	0.80	NUM
admet-995	146	23	4.49	4.49	NUM
admet-995	146	24	clemastine	clemastine	NOUN
admet-995	146	25	343.89	343.89	NUM
admet-995	146	26	0	0	NUM
admet-995	146	27	2	2	NUM
admet-995	146	28	12.5	12.5	NUM
admet-995	146	29	5.79	5.79	NUM
admet-995	146	30	3.63	3.63	NUM
admet-995	146	31	0.99	0.99	NUM
admet-995	146	32	0.00	0.00	NUM
admet-995	146	33	0.00	0.00	NUM
admet-995	146	34	0.00	0.00	NUM
admet-995	146	35	0.97	0.97	NUM
admet-995	146	36	clozapine	clozapine	NOUN
admet-995	146	37	326.82	326.82	NUM
admet-995	146	38	1	1	NUM
admet-995	146	39	4	4	NUM
admet-995	146	40	30.9	30.9	NUM
admet-995	146	41	3.32	3.32	NUM
admet-995	146	42	4.68	4.68	NUM
admet-995	146	43	0.58	0.58	NUM
admet-995	146	44	0.00	0.00	NUM
admet-995	146	45	0.00	0.00	NUM
admet-995	146	46	0.18	0.18	NUM
admet-995	146	47	1.44	1.44	NUM
admet-995	146	48	desipramine	desipramine	NOUN
admet-995	146	49	266.38	266.38	NUM
admet-995	146	50	1	1	NUM
admet-995	146	51	2	2	NUM
admet-995	146	52	15.3	15.3	NUM
admet-995	146	53	4.90	4.90	NUM
admet-995	146	54	1.57	1.57	NUM
admet-995	146	55	1.00	1.00	NUM
admet-995	146	56	0.00	0.00	NUM
admet-995	146	57	0.00	0.00	NUM
admet-995	146	58	0.09	0.09	NUM
admet-995	146	59	0.91	0.91	NUM
admet-995	146	60	diltiazem	diltiazem	NOUN
admet-995	146	61	414.52	414.52	NUM
admet-995	146	62	0	0	NUM
admet-995	146	63	6	6	NUM
admet-995	146	64	84.4	84.4	NUM
admet-995	146	65	2.70	2.70	NUM
admet-995	146	66	1.97	1.97	NUM
admet-995	146	67	1.00	1.00	NUM
admet-995	146	68	0.00	0.00	NUM
admet-995	146	69	0.00	0.00	NUM
admet-995	146	70	0.00	0.00	NUM
admet-995	146	71	2.12	2.12	NUM
admet-995	146	72	dolasetron	dolasetron	NOUN
admet-995	146	73	324.37	324.37	NUM
admet-995	146	74	1	1	NUM
admet-995	146	75	5	5	NUM
admet-995	146	76	62.4	62.4	NUM
admet-995	146	77	2.70	2.70	NUM
admet-995	146	78	2.66	2.66	NUM
admet-995	146	79	0.10	0.10	NUM
admet-995	146	80	0.00	0.00	NUM
admet-995	146	81	0.00	0.00	NUM
admet-995	146	82	0.31	0.31	NUM
admet-995	146	83	1.52	1.52	NUM
admet-995	146	84	domperidone	domperidone	NOUN
admet-995	146	85	425.92	425.92	NUM
admet-995	146	86	2	2	NUM
admet-995	146	87	7	7	NUM
admet-995	146	88	67.9	67.9	NUM
admet-995	146	89	4.05	4.05	NUM
admet-995	146	90	3.49	3.49	NUM
admet-995	146	91	0.85	0.85	NUM
admet-995	146	92	0.00	0.00	NUM
admet-995	146	93	0.00	0.00	NUM
admet-995	146	94	0.72	0.72	NUM
admet-995	146	95	1.83	1.83	NUM
admet-995	146	96	doxazosin	doxazosin	VERB
admet-995	146	97	451.47	451.47	NUM
admet-995	146	98	2	2	NUM
admet-995	146	99	10	10	NUM
admet-995	146	100	112.3	112.3	NUM
admet-995	146	101	2.07	2.07	NUM
admet-995	146	102	1.97	1.97	NUM
admet-995	146	103	0.22	0.22	NUM
admet-995	146	104	0.00	0.00	NUM
admet-995	146	105	0.00	0.00	NUM
admet-995	146	106	0.23	0.23	NUM
admet-995	146	107	2.60	2.60	NUM
admet-995	146	108	droperidol	droperidol	NOUN
admet-995	146	109	379.43	379.43	NUM
admet-995	146	110	1	1	NUM
admet-995	146	111	5	5	NUM
admet-995	146	112	52.7	52.7	NUM
admet-995	146	113	3.50	3.50	NUM
admet-995	146	114	2.61	2.61	NUM
admet-995	146	115	0.85	0.85	NUM
admet-995	146	116	0.00	0.00	NUM
admet-995	146	117	0.00	0.00	NUM
admet-995	146	118	0.33	0.33	NUM
admet-995	146	119	1.67	1.67	NUM
admet-995	146	120	ebastine	ebastine	NOUN
admet-995	146	121	469.66	469.66	NUM
admet-995	146	122	0	0	NUM
admet-995	146	123	3	3	NUM
admet-995	146	124	29.5	29.5	NUM
admet-995	146	125	7.55	7.55	NUM
admet-995	146	126	6.14	6.14	NUM
admet-995	146	127	0.97	0.97	NUM
admet-995	146	128	0.00	0.00	NUM
admet-995	146	129	0.00	0.00	NUM
admet-995	146	130	0.00	0.00	NUM
admet-995	146	131	1.41	1.41	NUM
admet-995	146	132	erythromycin	erythromycin	NOUN
admet-995	146	133	733.92	733.92	NUM
admet-995	146	134	5	5	NUM
admet-995	146	135	14	14	NUM
admet-995	146	136	193.9	193.9	NUM
admet-995	146	137	2.54	2.54	NUM
admet-995	146	138	0.65	0.65	NUM
admet-995	146	139	0.95	0.95	NUM
admet-995	146	140	0.00	0.00	NUM
admet-995	146	141	0.00	0.00	NUM
admet-995	146	142	1.05	1.05	NUM
admet-995	146	143	4.63	4.63	NUM
admet-995	146	144	fexofenadine	fexofenadine	NOUN
admet-995	146	145	501.65	501.65	NUM
admet-995	146	146	3	3	NUM
admet-995	146	147	5	5	NUM
admet-995	146	148	81.0	81.0	NUM
admet-995	146	149	4.35	4.35	NUM
admet-995	146	150	1.83	1.83	NUM
admet-995	146	151	0.00	0.00	NUM
admet-995	146	152	0.04	0.04	NUM
admet-995	146	153	0.97	0.97	NUM
admet-995	146	154	1.20	1.20	NUM
admet-995	146	155	2.12	2.12	NUM
admet-995	146	156	fluvoxamine	fluvoxamine	NOUN
admet-995	146	157	318.33	318.33	NUM
admet-995	146	158	2	2	NUM
admet-995	146	159	4	4	NUM
admet-995	146	160	56.8	56.8	NUM
admet-995	146	161	3.63	3.63	NUM
admet-995	146	162	2.32	2.32	NUM
admet-995	146	163	0.96	0.96	NUM
admet-995	146	164	0.00	0.00	NUM
admet-995	146	165	0.00	0.00	NUM
admet-995	146	166	0.23	0.23	NUM
admet-995	146	167	1.14	1.14	NUM
admet-995	146	168	glibenclamide	glibenclamide	ADP
admet-995	146	169	494.00	494.00	NUM
admet-995	146	170	3	3	NUM
admet-995	146	171	8	8	NUM
admet-995	146	172	122.0	122.0	NUM
admet-995	146	173	4.02	4.02	NUM
admet-995	146	174	1.83	1.83	NUM
admet-995	146	175	0.00	0.00	NUM
admet-995	146	176	0.99	0.99	NUM
admet-995	146	177	0.00	0.00	NUM
admet-995	146	178	0.85	0.85	NUM
admet-995	146	179	2.01	2.01	NUM
admet-995	146	180	glimepiride	glimepiride	NOUN
admet-995	146	181	490.62	490.62	NUM
admet-995	146	182	3	3	NUM
admet-995	146	183	9	9	NUM
admet-995	146	184	133.1	133.1	NUM
admet-995	146	185	4.25	4.25	NUM
admet-995	146	186	2.05	2.05	NUM
admet-995	146	187	0.99	0.99	NUM
admet-995	146	188	0.00	0.00	NUM
admet-995	146	189	0.00	0.00	NUM
admet-995	146	190	0.75	0.75	NUM
admet-995	146	191	2.15	2.15	NUM
admet-995	146	192	granisetron	granisetron	NOUN
admet-995	146	193	312.41	312.41	NUM
admet-995	146	194	1	1	NUM
admet-995	146	195	5	5	NUM
admet-995	146	196	50.2	50.2	NUM
admet-995	146	197	0.79	0.79	NUM
admet-995	146	198	-1.31	-1.31	NUM
admet-995	146	199	0.99	0.99	NUM
admet-995	146	200	0.00	0.00	NUM
admet-995	146	201	0.00	0.00	NUM
admet-995	146	202	0.26	0.26	NUM
admet-995	146	203	1.56	1.56	NUM
admet-995	146	204	imipramine	imipramine	NOUN
admet-995	146	205	280.41	280.41	NUM
admet-995	146	206	0	0	NUM
admet-995	146	207	2	2	NUM
admet-995	146	208	4.8	4.8	NUM
admet-995	146	209	4.28	4.28	NUM
admet-995	146	210	2.61	2.61	NUM
admet-995	146	211	0.99	0.99	NUM
admet-995	146	212	0.00	0.00	NUM
admet-995	146	213	0.00	0.00	NUM
admet-995	146	214	0.00	0.00	NUM
admet-995	146	215	1.15	1.15	NUM
admet-995	146	216	isradipine	isradipine	NOUN
admet-995	146	217	371.39	371.39	NUM
admet-995	146	218	1	1	NUM
admet-995	146	219	8	8	NUM
admet-995	146	220	103.6	103.6	NUM
admet-995	146	221	4.18	4.18	NUM
admet-995	146	222	1.48	1.48	NUM
admet-995	146	223	0.00	0.00	NUM
admet-995	146	224	0.00	0.00	NUM
admet-995	146	225	0.00	0.00	NUM
admet-995	146	226	0.13	0.13	NUM
admet-995	146	227	1.79	1.79	NUM
admet-995	146	228	ketoconazole	ketoconazole	NOUN
admet-995	146	229	531.43	531.43	NUM
admet-995	146	230	0	0	NUM
admet-995	146	231	8	8	NUM
admet-995	146	232	69.1	69.1	NUM
admet-995	146	233	4.34	4.34	NUM
admet-995	146	234	3.98	3.98	NUM
admet-995	146	235	0.15	0.15	NUM
admet-995	146	236	0.00	0.00	NUM
admet-995	146	237	0.00	0.00	NUM
admet-995	146	238	0.00	0.00	NUM
admet-995	146	239	2.22	2.22	NUM
admet-995	146	240	levobupivacaine	levobupivacaine	NOUN
admet-995	146	241	288.43	288.43	NUM
admet-995	146	242	1	1	NUM
admet-995	146	243	3	3	NUM
admet-995	146	244	32.3	32.3	NUM
admet-995	146	245	4.35	4.35	NUM
admet-995	146	246	3.73	3.73	NUM
admet-995	146	247	0.78	0.78	NUM
admet-995	146	248	0.00	0.00	NUM
admet-995	146	249	0.00	0.00	NUM
admet-995	146	250	0.26	0.26	NUM
admet-995	146	251	1.19	1.19	NUM
admet-995	146	252	levofloxacin	levofloxacin	NOUN
admet-995	146	253	361.37	361.37	NUM
admet-995	146	254	1	1	NUM
admet-995	146	255	7	7	NUM
admet-995	146	256	73.3	73.3	NUM
admet-995	146	257	-0.24	-0.24	NUM
admet-995	146	258	-2.34	-2.34	NUM
admet-995	146	259	0.05	0.05	NUM
admet-995	146	260	0.10	0.10	NUM
admet-995	146	261	0.85	0.85	NUM
admet-995	146	262	0.57	0.57	NUM
admet-995	146	263	2.05	2.05	NUM
admet-995	146	264	lidocaine	lidocaine	NOUN
admet-995	146	265	234.34	234.34	NUM
admet-995	146	266	1	1	NUM
admet-995	146	267	3	3	NUM
admet-995	146	268	32.3	32.3	NUM
admet-995	146	269	2.26	2.26	NUM
admet-995	146	270	2.44	2.44	NUM
admet-995	146	271	0.78	0.78	NUM
admet-995	146	272	0.00	0.00	NUM
admet-995	146	273	0.00	0.00	NUM
admet-995	146	274	0.12	0.12	NUM
admet-995	146	275	1.21	1.21	NUM
admet-995	146	276	lomefloxacin	lomefloxacin	PROPN
admet-995	146	277	351.35	351.35	NUM
admet-995	146	278	2	2	NUM
admet-995	146	279	6	6	NUM
admet-995	146	280	72.9	72.9	NUM
admet-995	146	281	-0.80	-0.80	NOUN
admet-995	146	282	-3.43	-3.43	NOUN
admet-995	146	283	0.05	0.05	NUM
admet-995	146	284	0.03	0.03	NUM
admet-995	146	285	0.91	0.91	NUM
admet-995	146	286	0.73	0.73	NUM
admet-995	146	287	1.81	1.81	NUM
admet-995	146	288	loratadine	loratadine	NOUN
admet-995	146	289	382.88	382.88	NUM
admet-995	146	290	0	0	NUM
admet-995	146	291	4	4	NUM
admet-995	146	292	42.4	42.4	NUM
admet-995	146	293	5.20	5.20	NUM
admet-995	146	294	4.94	4.94	NUM
admet-995	146	295	0.00	0.00	NUM
admet-995	146	296	0.00	0.00	NUM
admet-995	146	297	0.00	0.00	NUM
admet-995	146	298	0.00	0.00	NUM
admet-995	146	299	1.14	1.14	NUM
admet-995	146	300	lovastatin	lovastatin	NOUN
admet-995	146	301	404.54	404.54	NUM
admet-995	146	302	1	1	NUM
admet-995	146	303	5	5	NUM
admet-995	146	304	72.8	72.8	NUM
admet-995	146	305	4.26	4.26	NUM
admet-995	146	306	4.40	4.40	NUM
admet-995	146	307	0.00	0.00	NUM
admet-995	146	308	0.00	0.00	NUM
admet-995	146	309	0.00	0.00	NUM
admet-995	146	310	0.31	0.31	NUM
admet-995	146	311	1.44	1.44	NUM
admet-995	146	312	maprotiline	maprotiline	VERB
admet-995	146	313	277.41	277.41	NUM
admet-995	146	314	1	1	NUM
admet-995	146	315	1	1	NUM
admet-995	146	316	12.0	12.0	NUM
admet-995	146	317	4.85	4.85	NUM
admet-995	146	318	1.48	1.48	NUM
admet-995	146	319	1.00	1.00	NUM
admet-995	146	320	0.00	0.00	NUM
admet-995	146	321	0.00	0.00	NUM
admet-995	146	322	0.13	0.13	NUM
admet-995	146	323	0.68	0.68	NUM
admet-995	146	324	mefloquine	mefloquine	NOUN
admet-995	146	325	378.31	378.31	NUM
admet-995	146	326	2	2	NUM
admet-995	146	327	3	3	NUM
admet-995	146	328	45.2	45.2	NUM
admet-995	146	329	3.28	3.28	NUM
admet-995	146	330	1.50	1.50	NUM
admet-995	146	331	0.99	0.99	NUM
admet-995	146	332	0.00	0.00	NUM
admet-995	146	333	0.00	0.00	NUM
admet-995	146	334	0.38	0.38	NUM
admet-995	146	335	1.22	1.22	NUM
admet-995	146	336	metoclopramide	metoclopramide	NOUN
admet-995	146	337	299.80	299.80	NUM
admet-995	146	338	3	3	NUM
admet-995	146	339	5	5	NUM
admet-995	146	340	67.6	67.6	NUM
admet-995	146	341	1.40	1.40	NUM
admet-995	146	342	0.36	0.36	NUM
admet-995	146	343	0.99	0.99	NUM
admet-995	146	344	0.00	0.00	NUM
admet-995	146	345	0.00	0.00	NUM
admet-995	146	346	0.50	0.50	NUM
admet-995	146	347	1.63	1.63	NUM
admet-995	146	348	mibefradil	mibefradil	NOUN
admet-995	146	349	495.63	495.63	NUM
admet-995	146	350	1	1	NUM
admet-995	146	351	6	6	NUM
admet-995	146	352	67.5	67.5	NUM
admet-995	146	353	4.97	4.97	NUM
admet-995	146	354	2.37	2.37	NUM
admet-995	146	355	1.00	1.00	NUM
admet-995	146	356	0.00	0.00	NUM
admet-995	146	357	0.00	0.00	NUM
admet-995	146	358	0.35	0.35	NUM
admet-995	146	359	1.80	1.80	NUM
admet-995	146	360	miconazole	miconazole	NOUN
admet-995	146	361	416.13	416.13	NUM
admet-995	146	362	0	0	NUM
admet-995	146	363	3	3	NUM
admet-995	146	364	27.1	27.1	NUM
admet-995	146	365	5.34	5.34	NUM
admet-995	146	366	5.45	5.45	NUM
admet-995	146	367	0.15	0.15	NUM
admet-995	146	368	0.00	0.00	NUM
admet-995	146	369	0.00	0.00	NUM
admet-995	146	370	0.00	0.00	NUM
admet-995	146	371	0.79	0.79	NUM
admet-995	146	372	moxifloxacin	moxifloxacin	NUM
admet-995	146	373	401.43	401.43	NUM
admet-995	146	374	2	2	NUM
admet-995	146	375	7	7	NUM
admet-995	146	376	82.1	82.1	NUM
admet-995	146	377	-0.08	-0.08	NUM
admet-995	146	378	-2.87	-2.87	VERB
admet-995	146	379	0.05	0.05	NUM
admet-995	146	380	0.01	0.01	NUM
admet-995	146	381	0.94	0.94	NUM
admet-995	146	382	0.72	0.72	NUM
admet-995	146	383	2.04	2.04	NUM
admet-995	146	384	nicotine	nicotine	NOUN
admet-995	146	385	162.23	162.23	NUM
admet-995	146	386	0	0	NUM
admet-995	146	387	2	2	NUM
admet-995	146	388	16.1	16.1	NUM
admet-995	146	389	0.75	0.75	NUM
admet-995	146	390	-0.12	-0.12	NUM
admet-995	146	391	0.88	0.88	NUM
admet-995	146	392	0.00	0.00	NUM
admet-995	146	393	0.00	0.00	NUM
admet-995	146	394	0.00	0.00	NUM
admet-995	146	395	0.91	0.91	NUM
admet-995	146	396	nifedipine	nifedipine	NOUN
admet-995	146	397	346.33	346.33	NUM
admet-995	146	398	1	1	NUM
admet-995	146	399	8	8	NUM
admet-995	146	400	113.4	113.4	NUM
admet-995	146	401	3.27	3.27	NUM
admet-995	146	402	1.12	1.12	NUM
admet-995	146	403	1.00	1.00	NUM
admet-995	146	404	0.00	0.00	NUM
admet-995	146	405	0.00	0.00	NUM
admet-995	146	406	0.23	0.23	NUM
admet-995	146	407	1.45	1.45	NUM
admet-995	146	408	nitrendipine	nitrendipine	NOUN
admet-995	146	409	360.36	360.36	NUM
admet-995	146	410	1	1	NUM
admet-995	146	411	8	8	NUM
admet-995	146	412	113.5	113.5	NUM
admet-995	146	413	4.15	4.15	NUM
admet-995	146	414	1.60	1.60	NUM
admet-995	146	415	0.00	0.00	NUM
admet-995	146	416	0.00	0.00	NUM
admet-995	146	417	0.00	0.00	NUM
admet-995	146	418	0.13	0.13	NUM
admet-995	146	419	1.54	1.54	NUM
admet-995	146	420	ofloxacin	ofloxacin	NOUN
admet-995	146	421	361.37	361.37	NUM
admet-995	146	422	1	1	NUM
admet-995	146	423	7	7	NUM
admet-995	146	424	73.3	73.3	NUM
admet-995	146	425	-0.39	-0.39	NUM
admet-995	146	426	-2.34	-2.34	NUM
admet-995	146	427	0.05	0.05	NUM
admet-995	146	428	0.10	0.10	NUM
admet-995	146	429	0.85	0.85	NUM
admet-995	146	430	0.57	0.57	NUM
admet-995	146	431	2.05	2.05	NUM
admet-995	146	432	olanzapine	olanzapine	NOUN
admet-995	146	433	312.44	312.44	NUM
admet-995	146	434	1	1	NUM
admet-995	146	435	4	4	NUM
admet-995	146	436	59.1	59.1	NUM
admet-995	146	437	3.00	3.00	NUM
admet-995	146	438	4.05	4.05	NUM
admet-995	146	439	0.58	0.58	NUM
admet-995	146	440	0.00	0.00	NUM
admet-995	146	441	0.00	0.00	NUM
admet-995	146	442	0.13	0.13	NUM
admet-995	146	443	1.45	1.45	NUM
admet-995	146	444	ondansetron	ondansetron	NOUN
admet-995	146	445	293.36	293.36	NUM
admet-995	146	446	0	0	NUM
admet-995	146	447	4	4	NUM
admet-995	146	448	39.8	39.8	NUM
admet-995	146	449	1.96	1.96	NUM
admet-995	146	450	1.09	1.09	NUM
admet-995	146	451	0.88	0.88	NUM
admet-995	146	452	0.00	0.00	NUM
admet-995	146	453	0.00	0.00	NUM
admet-995	146	454	0.00	0.00	NUM
admet-995	146	455	1.53	1.53	NUM
admet-995	146	456	pergolide	pergolide	NOUN
admet-995	146	457	314.49	314.49	NUM
admet-995	146	458	1	1	NUM
admet-995	146	459	2	2	NUM
admet-995	146	460	44.3	44.3	NUM
admet-995	146	461	4.01	4.01	NUM
admet-995	146	462	2.97	2.97	NUM
admet-995	146	463	0.92	0.92	NUM
admet-995	146	464	0.00	0.00	NUM
admet-995	146	465	0.00	0.00	NUM
admet-995	146	466	0.31	0.31	NUM
admet-995	146	467	1.01	1.01	NUM
admet-995	146	468	perphenazine	perphenazine	ADJ
admet-995	146	469	403.97	403.97	NUM
admet-995	146	470	1	1	NUM
admet-995	146	471	4	4	NUM
admet-995	146	472	55.3	55.3	NUM
admet-995	146	473	3.69	3.69	NUM
admet-995	146	474	3.86	3.86	NUM
admet-995	146	475	0.74	0.74	NUM
admet-995	146	476	0.00	0.00	NUM
admet-995	146	477	0.00	0.00	NUM
admet-995	146	478	0.23	0.23	NUM
admet-995	146	479	1.84	1.84	NUM
admet-995	146	480	phenytoin	phenytoin	NOUN
admet-995	146	481	252.27	252.27	NUM
admet-995	146	482	2	2	NUM
admet-995	146	483	4	4	NUM
admet-995	146	484	58.2	58.2	NUM
admet-995	146	485	2.15	2.15	NUM
admet-995	146	486	1.90	1.90	NUM
admet-995	146	487	0.00	0.00	NUM
admet-995	146	488	0.10	0.10	NUM
admet-995	146	489	0.00	0.00	NUM
admet-995	146	490	0.85	0.85	NUM
admet-995	146	491	1.00	1.00	NUM
admet-995	146	492	pimozide	pimozide	ADJ
admet-995	146	493	461.54	461.54	NUM
admet-995	146	494	1	1	NUM
admet-995	146	495	4	4	NUM
admet-995	146	496	35.6	35.6	NUM
admet-995	146	497	6.30	6.30	NUM
admet-995	146	498	5.49	5.49	NUM
admet-995	146	499	0.85	0.85	NUM
admet-995	146	500	0.00	0.00	NUM
admet-995	146	501	0.00	0.00	NUM
admet-995	146	502	0.33	0.33	NUM
admet-995	146	503	1.44	1.44	NUM
admet-995	146	504	prazosin	prazosin	NOUN
admet-995	146	505	383.40	383.40	NUM
admet-995	146	506	2	2	NUM
admet-995	146	507	9	9	NUM
admet-995	146	508	107.0	107.0	NUM
admet-995	146	509	0.45	0.45	NUM
admet-995	146	510	0.35	0.35	NUM
admet-995	146	511	0.22	0.22	NUM
admet-995	146	512	0.00	0.00	NUM
admet-995	146	513	0.00	0.00	NUM
admet-995	146	514	0.23	0.23	NUM
admet-995	146	515	2.17	2.17	NUM
admet-995	146	516	procainamide	procainamide	NOUN
admet-995	146	517	235.32	235.32	NUM
admet-995	146	518	2	2	NUM
admet-995	146	519	4	4	NUM
admet-995	146	520	58.4	58.4	NUM
admet-995	146	521	0.88	0.88	NUM
admet-995	146	522	-0.83	-0.83	NUM
admet-995	146	523	0.99	0.99	NUM
admet-995	146	524	0.00	0.00	NUM
admet-995	146	525	0.00	0.00	NUM
admet-995	146	526	0.50	0.50	NUM
admet-995	146	527	1.45	1.45	NUM
admet-995	146	528	propafenone	propafenone	NOUN
admet-995	146	529	341.44	341.44	NUM
admet-995	146	530	2	2	NUM
admet-995	146	531	4	4	NUM
admet-995	146	532	58.6	58.6	NUM
admet-995	146	533	3.41	3.41	NUM
admet-995	146	534	1.26	1.26	NUM
admet-995	146	535	0.99	0.99	NUM
admet-995	146	536	0.00	0.00	NUM
admet-995	146	537	0.00	0.00	NUM
admet-995	146	538	0.29	0.29	NUM
admet-995	146	539	1.67	1.67	NUM
admet-995	146	540	http://dx.doi.org/10.5599/admet.0000	http://dx.doi.org/10.5599/admet.0000	NOUN
admet-995	146	541	stergiopoulos	stergiopoulos	PROPN
admet-995	146	542	,	,	PUNCT
admet-995	146	543	tsopelas	tsopela	NOUN
admet-995	146	544	and	and	CCONJ
admet-995	146	545	valko	valko	PROPN
admet-995	146	546	admet	admet	PROPN
admet-995	146	547	&	&	CCONJ
admet-995	146	548	dmpk	dmpk	PROPN
admet-995	146	549	9(3	9(3	NUM
admet-995	146	550	)	)	PUNCT
admet-995	146	551	(	(	PUNCT
admet-995	146	552	2021	2021	NUM
admet-995	146	553	)	)	PUNCT
admet-995	146	554	191	191	NUM
admet-995	146	555	-	-	SYM
admet-995	146	556	207	207	NUM
admet-995	146	557	200	200	NUM
admet-995	146	558	table	table	NOUN
admet-995	146	559	5	5	NUM
admet-995	146	560	.	.	PUNCT
admet-995	146	561	cont’d	cont’d	NOUN
admet-995	146	562	propiverine	propiverine	NOUN
admet-995	147	1	367.48	367.48	NUM
admet-995	147	2	0	0	NUM
admet-995	147	3	4	4	NUM
admet-995	147	4	38.8	38.8	NUM
admet-995	147	5	4.01	4.01	NUM
admet-995	147	6	1.53	1.53	NUM
admet-995	147	7	1.00	1.00	NUM
admet-995	147	8	0.00	0.00	NUM
admet-995	147	9	0.00	0.00	NUM
admet-995	147	10	0.00	0.00	NUM
admet-995	147	11	1.31	1.31	NUM
admet-995	147	12	propranolol	propranolol	NOUN
admet-995	147	13	259.34	259.34	NUM
admet-995	147	14	2	2	NUM
admet-995	147	15	3	3	NUM
admet-995	147	16	41.5	41.5	NUM
admet-995	147	17	3.09	3.09	NUM
admet-995	147	18	0.89	0.89	NUM
admet-995	147	19	0.99	0.99	NUM
admet-995	147	20	0.00	0.00	NUM
admet-995	147	21	0.00	0.00	NUM
admet-995	147	22	0.17	0.17	NUM
admet-995	147	23	1.42	1.42	NUM
admet-995	147	24	pyrilamine	pyrilamine	NOUN
admet-995	147	25	285.38	285.38	NUM
admet-995	147	26	0	0	NUM
admet-995	147	27	4	4	NUM
admet-995	147	28	28.6	28.6	NUM
admet-995	147	29	3.27	3.27	NUM
admet-995	147	30	1.63	1.63	NUM
admet-995	147	31	0.97	0.97	NUM
admet-995	147	32	0.00	0.00	NUM
admet-995	147	33	0.00	0.00	NUM
admet-995	147	34	0.00	0.00	NUM
admet-995	147	35	1.59	1.59	NUM
admet-995	147	36	quetiapine	quetiapine	NOUN
admet-995	147	37	383.51	383.51	NUM
admet-995	147	38	1	1	NUM
admet-995	147	39	5	5	NUM
admet-995	147	40	73.6	73.6	NUM
admet-995	147	41	2.27	2.27	NUM
admet-995	147	42	1.91	1.91	NUM
admet-995	147	43	0.58	0.58	NUM
admet-995	147	44	0.00	0.00	NUM
admet-995	147	45	0.00	0.00	NUM
admet-995	147	46	0.23	0.23	NUM
admet-995	147	47	2.01	2.01	NUM
admet-995	147	48	quinidine	quinidine	PROPN
admet-995	147	49	324.42	324.42	NUM
admet-995	147	50	1	1	NUM
admet-995	147	51	4	4	NUM
admet-995	147	52	45.6	45.6	NUM
admet-995	147	53	2.64	2.64	NUM
admet-995	147	54	1.06	1.06	NUM
admet-995	147	55	0.95	0.95	NUM
admet-995	147	56	0.00	0.00	NUM
admet-995	147	57	0.00	0.00	NUM
admet-995	147	58	0.23	0.23	NUM
admet-995	147	59	1.81	1.81	NUM
admet-995	147	60	risperidone	risperidone	NOUN
admet-995	147	61	410.48	410.48	NUM
admet-995	147	62	0	0	NUM
admet-995	147	63	6	6	NUM
admet-995	147	64	61.9	61.9	NUM
admet-995	147	65	3.04	3.04	NUM
admet-995	147	66	1.09	1.09	NUM
admet-995	147	67	0.88	0.88	NUM
admet-995	147	68	0.00	0.00	NUM
admet-995	147	69	0.00	0.00	NUM
admet-995	147	70	0.00	0.00	NUM
admet-995	147	71	1.70	1.70	NUM
admet-995	147	72	ritonavir	ritonavir	PROPN
admet-995	147	73	720.94	720.94	NUM
admet-995	147	74	4	4	NUM
admet-995	147	75	11	11	NUM
admet-995	147	76	202.3	202.3	NUM
admet-995	147	77	5.64	5.64	NUM
admet-995	147	78	5.64	5.64	NUM
admet-995	147	79	0.00	0.00	NUM
admet-995	147	80	0.00	0.00	NUM
admet-995	147	81	0.00	0.00	NUM
admet-995	147	82	0.88	0.88	NUM
admet-995	147	83	3.14	3.14	NUM
admet-995	147	84	roxithromycin	roxithromycin	NOUN
admet-995	147	85	837.04	837.04	NUM
admet-995	147	86	5	5	NUM
admet-995	147	87	17	17	NUM
admet-995	147	88	216.9	216.9	NUM
admet-995	147	89	3.79	3.79	NUM
admet-995	147	90	1.00	1.00	NUM
admet-995	147	91	0.95	0.95	NUM
admet-995	147	92	0.00	0.00	NUM
admet-995	147	93	0.00	0.00	NUM
admet-995	147	94	1.05	1.05	NUM
admet-995	147	95	5.12	5.12	NUM
admet-995	147	96	saquinavir	saquinavir	NOUN
admet-995	147	97	670.84	670.84	NUM
admet-995	147	98	6	6	NUM
admet-995	147	99	11	11	NUM
admet-995	147	100	166.8	166.8	NUM
admet-995	147	101	3.77	3.77	NUM
admet-995	147	102	3.67	3.67	NUM
admet-995	147	103	0.22	0.22	NUM
admet-995	147	104	0.00	0.00	NUM
admet-995	147	105	0.00	0.00	NUM
admet-995	147	106	1.46	1.46	NUM
admet-995	147	107	3.89	3.89	NUM
admet-995	147	108	sotalol	sotalol	NOUN
admet-995	147	109	272.36	272.36	NUM
admet-995	147	110	3	3	NUM
admet-995	147	111	5	5	NUM
admet-995	147	112	86.8	86.8	NUM
admet-995	147	113	0.24	0.24	NUM
admet-995	147	114	-1.35	-1.35	NUM
admet-995	147	115	0.91	0.91	NUM
admet-995	147	116	0.00	0.00	NUM
admet-995	147	117	0.08	0.08	NUM
admet-995	147	118	0.74	0.74	NUM
admet-995	147	119	1.75	1.75	NUM
admet-995	147	120	sulfamethoxazole	sulfamethoxazole	NOUN
admet-995	147	121	253.28	253.28	NUM
admet-995	147	122	3	3	NUM
admet-995	147	123	6	6	NUM
admet-995	147	124	106.6	106.6	NUM
admet-995	147	125	0.89	0.89	NUM
admet-995	147	126	-0.85	-0.85	NOUN
admet-995	147	127	0.00	0.00	NUM
admet-995	147	128	0.98	0.98	NUM
admet-995	147	129	0.00	0.00	NUM
admet-995	147	130	0.59	0.59	NUM
admet-995	147	131	1.21	1.21	NUM
admet-995	147	132	tamsulosin	tamsulosin	NOUN
admet-995	147	133	408.51	408.51	NUM
admet-995	147	134	2	2	NUM
admet-995	147	135	7	7	NUM
admet-995	147	136	119.3	119.3	NUM
admet-995	147	137	2.38	2.38	NUM
admet-995	147	138	1.07	1.07	NUM
admet-995	147	139	0.95	0.95	NUM
admet-995	147	140	0.00	0.00	NUM
admet-995	147	141	0.00	0.00	NUM
admet-995	147	142	0.59	0.59	NUM
admet-995	147	143	2.11	2.11	NUM
admet-995	147	144	thioridazine	thioridazine	PROPN
admet-995	147	145	370.58	370.58	NUM
admet-995	147	146	0	0	NUM
admet-995	147	147	2	2	NUM
admet-995	147	148	57.1	57.1	NUM
admet-995	147	149	5.90	5.90	NUM
admet-995	147	150	4.17	4.17	NUM
admet-995	147	151	0.99	0.99	NUM
admet-995	147	152	0.00	0.00	NUM
admet-995	147	153	0.00	0.00	NUM
admet-995	147	154	0.00	0.00	NUM
admet-995	147	155	1.13	1.13	NUM
admet-995	147	156	tolterodine	tolterodine	NOUN
admet-995	147	157	339.51	339.51	NUM
admet-995	147	158	1	1	NUM
admet-995	147	159	2	2	NUM
admet-995	147	160	23.5	23.5	NUM
admet-995	147	161	5.98	5.98	NUM
admet-995	147	162	3.49	3.49	NUM
admet-995	147	163	1.00	1.00	NUM
admet-995	147	164	0.00	0.00	NUM
admet-995	147	165	0.00	0.00	NUM
admet-995	147	166	0.50	0.50	NUM
admet-995	147	167	1.08	1.08	NUM
admet-995	147	168	trifluoperazine	trifluoperazine	NOUN
admet-995	147	169	407.50	407.50	NUM
admet-995	147	170	0	0	NUM
admet-995	147	171	3	3	NUM
admet-995	147	172	35.0	35.0	NUM
admet-995	147	173	5.03	5.03	NUM
admet-995	147	174	4.37	4.37	NUM
admet-995	147	175	0.85	0.85	NUM
admet-995	147	176	0.00	0.00	NUM
admet-995	147	177	0.00	0.00	NUM
admet-995	147	178	0.00	0.00	NUM
admet-995	147	179	1.50	1.50	NUM
admet-995	147	180	verapamil	verapamil	NOUN
admet-995	147	181	454.60	454.60	NUM
admet-995	147	182	0	0	NUM
admet-995	147	183	6	6	NUM
admet-995	147	184	64.0	64.0	NUM
admet-995	147	185	3.83	3.83	NUM
admet-995	147	186	3.17	3.17	NUM
admet-995	147	187	0.98	0.98	NUM
admet-995	147	188	0.00	0.00	NUM
admet-995	147	189	0.00	0.00	NUM
admet-995	147	190	0.00	0.00	NUM
admet-995	147	191	1.89	1.89	NUM
admet-995	147	192	alfuzosin	alfuzosin	NOUN
admet-995	147	193	389.45	389.45	NUM
admet-995	147	194	3	3	NUM
admet-995	147	195	9	9	NUM
admet-995	147	196	111.8	111.8	NUM
admet-995	147	197	-0.23	-0.23	NUM
admet-995	147	198	-0.85	-0.85	NUM
admet-995	147	199	0.78	0.78	NUM
admet-995	147	200	0.00	0.00	NUM
admet-995	147	201	0.00	0.00	NUM
admet-995	147	202	0.84	0.84	NUM
admet-995	147	203	2.24	2.24	NUM
admet-995	147	204	desloratadine	desloratadine	NOUN
admet-995	147	205	310.83	310.83	NUM
admet-995	147	206	1	1	NUM
admet-995	147	207	2	2	NUM
admet-995	147	208	24.9	24.9	NUM
admet-995	147	209	4.13	4.13	NUM
admet-995	147	210	2.42	2.42	NUM
admet-995	147	211	0.98	0.98	NUM
admet-995	147	212	0.00	0.00	NUM
admet-995	147	213	0.00	0.00	NUM
admet-995	147	214	0.13	0.13	NUM
admet-995	147	215	0.99	0.99	NUM
admet-995	147	216	diphenhydramine	diphenhydramine	NOUN
admet-995	147	217	255.35	255.35	NUM
admet-995	147	218	0	0	NUM
admet-995	147	219	2	2	NUM
admet-995	147	220	12.5	12.5	NUM
admet-995	147	221	3.40	3.40	NUM
admet-995	147	222	1.82	1.82	NUM
admet-995	147	223	0.97	0.97	NUM
admet-995	147	224	0.00	0.00	NUM
admet-995	147	225	0.00	0.00	NUM
admet-995	147	226	0.00	0.00	NUM
admet-995	147	227	0.95	0.95	NUM
admet-995	147	228	dofetilide	dofetilide	ADJ
admet-995	147	229	441.57	441.57	NUM
admet-995	147	230	2	2	NUM
admet-995	147	231	8	8	NUM
admet-995	147	232	121.6	121.6	NUM
admet-995	147	233	2.41	2.41	NUM
admet-995	147	234	1.06	1.06	NUM
admet-995	147	235	0.88	0.88	NUM
admet-995	147	236	0.00	0.00	NUM
admet-995	147	237	0.08	0.08	NUM
admet-995	147	238	0.72	0.72	NUM
admet-995	147	239	2.16	2.16	NUM
admet-995	147	240	flecainide	flecainide	ADP
admet-995	147	241	414.34	414.34	NUM
admet-995	147	242	2	2	NUM
admet-995	147	243	5	5	NUM
admet-995	147	244	59.6	59.6	NUM
admet-995	147	245	3.78	3.78	NUM
admet-995	147	246	0.32	0.32	NUM
admet-995	147	247	0.99	0.99	NUM
admet-995	147	248	0.00	0.00	NUM
admet-995	147	249	0.00	0.00	NUM
admet-995	147	250	0.41	0.41	NUM
admet-995	147	251	1.32	1.32	NUM
admet-995	147	252	fluoxetine	fluoxetine	NOUN
admet-995	147	253	309.33	309.33	NUM
admet-995	147	254	1	1	NUM
admet-995	147	255	2	2	NUM
admet-995	147	256	21.3	21.3	NUM
admet-995	147	257	4.50	4.50	NUM
admet-995	147	258	2.44	2.44	NUM
admet-995	147	259	1.00	1.00	NUM
admet-995	147	260	0.00	0.00	NUM
admet-995	147	261	0.00	0.00	NUM
admet-995	147	262	0.13	0.13	NUM
admet-995	147	263	0.78	0.78	NUM
admet-995	147	264	indomethacin	indomethacin	VERB
admet-995	147	265	357.79	357.79	NUM
admet-995	147	266	1	1	NUM
admet-995	147	267	5	5	NUM
admet-995	147	268	68.5	68.5	NUM
admet-995	147	269	4.27	4.27	NUM
admet-995	147	270	0.71	0.71	NUM
admet-995	147	271	0.00	0.00	NUM
admet-995	147	272	1.00	1.00	NUM
admet-995	147	273	0.00	0.00	NUM
admet-995	147	274	0.57	0.57	NUM
admet-995	147	275	1.57	1.57	NUM
admet-995	147	276	irbesartan	irbesartan	NOUN
admet-995	147	277	428.53	428.53	NUM
admet-995	147	278	1	1	NUM
admet-995	147	279	7	7	NUM
admet-995	147	280	87.1	87.1	NUM
admet-995	147	281	4.72	4.72	NUM
admet-995	147	282	2.22	2.22	NUM
admet-995	147	283	0.00	0.00	NUM
admet-995	147	284	0.00	0.00	NUM
admet-995	147	285	1.00	1.00	NUM
admet-995	147	286	0.56	0.56	NUM
admet-995	147	287	1.78	1.78	NUM
admet-995	147	288	lamotrigine	lamotrigine	NOUN
admet-995	147	289	256.09	256.09	NUM
admet-995	147	290	4	4	NUM
admet-995	147	291	5	5	NUM
admet-995	147	292	90.7	90.7	NUM
admet-995	147	293	2.63	2.63	NUM
admet-995	147	294	2.62	2.62	NUM
admet-995	147	295	0.01	0.01	NUM
admet-995	147	296	0.00	0.00	NUM
admet-995	147	297	0.00	0.00	NUM
admet-995	147	298	0.35	0.35	NUM
admet-995	147	299	0.96	0.96	NUM
admet-995	147	300	metoprolol	metoprolol	NOUN
admet-995	147	301	267.36	267.36	NUM
admet-995	147	302	2	2	NUM
admet-995	147	303	4	4	NUM
admet-995	147	304	50.7	50.7	NUM
admet-995	147	305	1.88	1.88	NUM
admet-995	147	306	-0.43	-0.43	NUM
admet-995	147	307	0.99	0.99	NUM
admet-995	147	308	0.00	0.00	NUM
admet-995	147	309	0.00	0.00	NUM
admet-995	147	310	0.17	0.17	NUM
admet-995	147	311	1.76	1.76	NUM
admet-995	147	312	protriptyline	protriptyline	NOUN
admet-995	147	313	263.38	263.38	NUM
admet-995	147	314	1	1	NUM
admet-995	147	315	1	1	NUM
admet-995	147	316	12.0	12.0	NUM
admet-995	147	317	4.91	4.91	NUM
admet-995	147	318	4.04	4.04	NUM
admet-995	147	319	0.88	0.88	NUM
admet-995	147	320	0.00	0.00	NUM
admet-995	147	321	0.00	0.00	NUM
admet-995	147	322	0.13	0.13	NUM
admet-995	147	323	0.73	0.73	NUM
admet-995	147	324	sildenafil	sildenafil	NOUN
admet-995	147	325	474.58	474.58	NUM
admet-995	147	326	1	1	NUM
admet-995	147	327	10	10	NUM
admet-995	147	328	117.5	117.5	NUM
admet-995	147	329	2.73	2.73	NUM
admet-995	147	330	2.47	2.47	NUM
admet-995	147	331	0.37	0.37	NUM
admet-995	147	332	0.06	0.06	NUM
admet-995	147	333	0.04	0.04	NUM
admet-995	147	334	0.26	0.26	NUM
admet-995	147	335	2.68	2.68	NUM
admet-995	147	336	spironolactone	spironolactone	NOUN
admet-995	147	337	416.57	416.57	NUM
admet-995	147	338	0	0	NUM
admet-995	147	339	4	4	NUM
admet-995	147	340	85.7	85.7	NUM
admet-995	147	341	2.52	2.52	NUM
admet-995	147	342	2.52	2.52	NUM
admet-995	147	343	0.00	0.00	NUM
admet-995	147	344	0.00	0.00	NUM
admet-995	147	345	0.00	0.00	NUM
admet-995	147	346	0.00	0.00	NUM
admet-995	147	347	1.63	1.63	NUM
admet-995	147	348	trazodone	trazodone	NOUN
admet-995	147	349	371.86	371.86	NUM
admet-995	147	350	0	0	NUM
admet-995	147	351	6	6	NUM
admet-995	147	352	42.4	42.4	NUM
admet-995	147	353	3.80	3.80	NUM
admet-995	147	354	4.60	4.60	NUM
admet-995	147	355	0.22	0.22	NUM
admet-995	147	356	0.00	0.00	NUM
admet-995	147	357	0.00	0.00	NUM
admet-995	147	358	0.00	0.00	NUM
admet-995	147	359	1.92	1.92	NUM
admet-995	147	360	trimethoprim	trimethoprim	NOUN
admet-995	147	361	290.32	290.32	NUM
admet-995	147	362	4	4	NUM
admet-995	147	363	7	7	NUM
admet-995	147	364	105.5	105.5	NUM
admet-995	147	365	1.28	1.28	NUM
admet-995	147	366	0.71	0.71	NUM
admet-995	147	367	0.47	0.47	NUM
admet-995	147	368	0.00	0.00	NUM
admet-995	147	369	0.00	0.00	NUM
admet-995	147	370	0.28	0.28	NUM
admet-995	147	371	1.62	1.62	NUM
admet-995	147	372	ziprasidone	ziprasidone	NOUN
admet-995	147	373	412.94	412.94	NUM
admet-995	147	374	1	1	NUM
admet-995	147	375	5	5	NUM
admet-995	147	376	46.7	46.7	NUM
admet-995	147	377	4.6	4.6	NUM
admet-995	147	378	4.14	4.14	NUM
admet-995	147	379	0.64	0.64	NUM
admet-995	147	380	0.00	0.00	NUM
admet-995	147	381	0.00	0.00	NUM
admet-995	147	382	0.48	0.48	NUM
admet-995	147	383	1.65	1.65	NUM
admet-995	147	384	selection	selection	NOUN
admet-995	147	385	of	of	ADP
admet-995	147	386	the	the	DET
admet-995	147	387	test	test	NOUN
admet-995	147	388	set	set	NOUN
admet-995	147	389	of	of	ADP
admet-995	147	390	compounds	compound	NOUN
admet-995	147	391	constructed	construct	VERB
admet-995	147	392	toxicity	toxicity	NOUN
admet-995	147	393	models	model	NOUN
admet-995	147	394	require	require	VERB
admet-995	147	395	external	external	ADJ
admet-995	147	396	validation	validation	NOUN
admet-995	147	397	to	to	PART
admet-995	147	398	prove	prove	VERB
admet-995	147	399	their	their	PRON
admet-995	147	400	predictive	predictive	ADJ
admet-995	147	401	ability	ability	NOUN
admet-995	147	402	.	.	PUNCT
admet-995	148	1	hence	hence	ADV
admet-995	148	2	,	,	PUNCT
admet-995	148	3	a	a	DET
admet-995	148	4	test	test	NOUN
admet-995	148	5	set	set	NOUN
admet-995	148	6	,	,	PUNCT
admet-995	148	7	usually	usually	ADV
admet-995	148	8	consisting	consist	VERB
admet-995	148	9	of	of	ADP
admet-995	148	10	about	about	ADV
admet-995	148	11	20	20	NUM
admet-995	148	12	%	%	NOUN
admet-995	148	13	of	of	ADP
admet-995	148	14	the	the	DET
admet-995	148	15	entire	entire	ADJ
admet-995	148	16	set	set	NOUN
admet-995	148	17	,	,	PUNCT
admet-995	148	18	is	be	AUX
admet-995	148	19	necessary	necessary	ADJ
admet-995	148	20	to	to	PART
admet-995	148	21	evaluate	evaluate	VERB
admet-995	148	22	the	the	DET
admet-995	148	23	established	establish	VERB
admet-995	148	24	models	model	NOUN
admet-995	148	25	in	in	ADP
admet-995	148	26	terms	term	NOUN
admet-995	148	27	of	of	ADP
admet-995	148	28	their	their	PRON
admet-995	148	29	predictive	predictive	ADJ
admet-995	148	30	performance	performance	NOUN
admet-995	148	31	[	[	X
admet-995	148	32	37	37	NUM
admet-995	148	33	]	]	PUNCT
admet-995	148	34	.	.	PUNCT
admet-995	149	1	for	for	ADP
admet-995	149	2	that	that	DET
admet-995	149	3	reason	reason	NOUN
admet-995	149	4	,	,	PUNCT
admet-995	149	5	a	a	DET
admet-995	149	6	principal	principal	ADJ
admet-995	149	7	component	component	NOUN
admet-995	149	8	analysis	analysis	NOUN
admet-995	149	9	using	use	VERB
admet-995	149	10	the	the	DET
admet-995	149	11	calculated	calculated	ADJ
admet-995	149	12	physicochemical	physicochemical	ADJ
admet-995	149	13	properties	property	NOUN
admet-995	149	14	of	of	ADP
admet-995	149	15	the	the	DET
admet-995	149	16	compounds	compound	NOUN
admet-995	149	17	was	be	AUX
admet-995	149	18	performed	perform	VERB
admet-995	149	19	.	.	PUNCT
admet-995	150	1	by	by	ADP
admet-995	150	2	plotting	plot	VERB
admet-995	150	3	the	the	DET
admet-995	150	4	first	first	ADJ
admet-995	150	5	two	two	NUM
admet-995	150	6	principal	principal	ADJ
admet-995	150	7	components	component	NOUN
admet-995	150	8	(	(	PUNCT
admet-995	150	9	figure	figure	NOUN
admet-995	150	10	1	1	NUM
admet-995	150	11	)	)	PUNCT
admet-995	150	12	,	,	PUNCT
admet-995	150	13	four	four	NUM
admet-995	150	14	compounds	compound	NOUN
admet-995	150	15	from	from	ADP
admet-995	150	16	each	each	DET
admet-995	150	17	quadrant	quadrant	NOUN
admet-995	150	18	were	be	AUX
admet-995	150	19	selected	select	VERB
admet-995	150	20	by	by	ADP
admet-995	150	21	taking	take	VERB
admet-995	150	22	into	into	ADP
admet-995	150	23	account	account	NOUN
admet-995	150	24	the	the	DET
admet-995	150	25	compounds	compound	NOUN
admet-995	150	26	'	'	PART
admet-995	150	27	therapeutic	therapeutic	ADJ
admet-995	150	28	areas	area	NOUN
admet-995	150	29	to	to	PART
admet-995	150	30	ensure	ensure	VERB
admet-995	150	31	the	the	DET
admet-995	150	32	test	test	NOUN
admet-995	150	33	set	set	NOUN
admet-995	150	34	's	's	PART
admet-995	150	35	diversity	diversity	NOUN
admet-995	150	36	.	.	PUNCT
admet-995	151	1	the	the	DET
admet-995	151	2	remaining	remain	VERB
admet-995	151	3	compounds	compound	NOUN
admet-995	151	4	were	be	AUX
admet-995	151	5	used	use	VERB
admet-995	151	6	for	for	ADP
admet-995	151	7	modelling	modelling	NOUN
admet-995	151	8	as	as	ADP
admet-995	151	9	the	the	DET
admet-995	151	10	training	training	NOUN
admet-995	151	11	set	set	NOUN
admet-995	151	12	.	.	PUNCT
admet-995	152	1	table	table	NOUN
admet-995	152	2	6	6	NUM
admet-995	152	3	shows	show	VERB
admet-995	152	4	the	the	DET
admet-995	152	5	therapeutic	therapeutic	ADJ
admet-995	152	6	areas	area	NOUN
admet-995	152	7	of	of	ADP
admet-995	152	8	the	the	DET
admet-995	152	9	compounds	compound	NOUN
admet-995	152	10	selected	select	VERB
admet-995	152	11	as	as	ADP
admet-995	152	12	the	the	DET
admet-995	152	13	test	test	NOUN
admet-995	152	14	set	set	VERB
admet-995	152	15	.	.	PUNCT
admet-995	153	1	admet	admet	PROPN
admet-995	153	2	&	&	CCONJ
admet-995	153	3	dmpk	dmpk	PROPN
admet-995	153	4	9(3	9(3	NUM
admet-995	153	5	)	)	PUNCT
admet-995	153	6	(	(	PUNCT
admet-995	153	7	2021	2021	NUM
admet-995	153	8	)	)	PUNCT
admet-995	153	9	191	191	NUM
admet-995	153	10	-	-	SYM
admet-995	153	11	207	207	NUM
admet-995	153	12	prediction	prediction	NOUN
admet-995	153	13	of	of	ADP
admet-995	153	14	herg	herg	PROPN
admet-995	153	15	inhibition	inhibition	NOUN
admet-995	153	16	by	by	ADP
admet-995	153	17	biomimetic	biomimetic	ADJ
admet-995	153	18	measurements	measurement	NOUN
admet-995	153	19	doi	doi	NOUN
admet-995	153	20	:	:	PUNCT
admet-995	153	21	http://dx.doi.org/10.5599/admet.995	http://dx.doi.org/10.5599/admet.995	ADJ
admet-995	153	22	201	201	NUM
admet-995	153	23	figure	figure	NOUN
admet-995	153	24	1	1	NUM
admet-995	153	25	the	the	DET
admet-995	153	26	score	score	NOUN
admet-995	153	27	plot	plot	NOUN
admet-995	153	28	from	from	ADP
admet-995	153	29	the	the	DET
admet-995	153	30	principal	principal	ADJ
admet-995	153	31	component	component	NOUN
admet-995	153	32	analysis	analysis	NOUN
admet-995	153	33	on	on	ADP
admet-995	153	34	the	the	DET
admet-995	153	35	calculated	calculate	VERB
admet-995	153	36	properties	property	NOUN
admet-995	153	37	.	.	PUNCT
admet-995	154	1	compounds	compound	NOUN
admet-995	154	2	served	serve	VERB
admet-995	154	3	as	as	SCONJ
admet-995	154	4	the	the	DET
admet-995	154	5	test	test	NOUN
admet-995	154	6	set	set	NOUN
admet-995	154	7	are	be	AUX
admet-995	154	8	marked	mark	VERB
admet-995	154	9	in	in	ADP
admet-995	154	10	red	red	ADJ
admet-995	154	11	,	,	PUNCT
admet-995	154	12	as	as	SCONJ
admet-995	154	13	follows	follow	VERB
admet-995	154	14	:	:	PUNCT
admet-995	154	15	(	(	PUNCT
admet-995	154	16	1	1	X
admet-995	154	17	)	)	PUNCT
admet-995	154	18	dofetilide	dofetilide	ADJ
admet-995	154	19	,	,	PUNCT
admet-995	154	20	(	(	PUNCT
admet-995	154	21	2	2	X
admet-995	154	22	)	)	PUNCT
admet-995	154	23	sildenafil	sildenafil	NOUN
admet-995	154	24	,	,	PUNCT
admet-995	154	25	(	(	PUNCT
admet-995	154	26	3	3	X
admet-995	154	27	)	)	PUNCT
admet-995	154	28	irbesartan	irbesartan	PROPN
admet-995	154	29	,	,	PUNCT
admet-995	154	30	(	(	PUNCT
admet-995	154	31	4	4	X
admet-995	154	32	)	)	PUNCT
admet-995	154	33	flecainide	flecainide	NOUN
admet-995	154	34	,	,	PUNCT
admet-995	154	35	(	(	PUNCT
admet-995	154	36	5	5	X
admet-995	154	37	)	)	PUNCT
admet-995	154	38	ziprasidone	ziprasidone	NOUN
admet-995	154	39	,	,	PUNCT
admet-995	154	40	(	(	PUNCT
admet-995	154	41	6	6	NUM
admet-995	154	42	)	)	PUNCT
admet-995	154	43	trazodone	trazodone	NOUN
admet-995	154	44	,	,	PUNCT
admet-995	154	45	(	(	PUNCT
admet-995	154	46	7	7	X
admet-995	154	47	)	)	PUNCT
admet-995	154	48	fluoxetine	fluoxetine	NOUN
admet-995	154	49	,	,	PUNCT
admet-995	154	50	(	(	PUNCT
admet-995	154	51	8)	8)	NUM
admet-995	154	52	protryptiline	protryptiline	NOUN
admet-995	154	53	,	,	PUNCT
admet-995	154	54	(	(	PUNCT
admet-995	154	55	9	9	X
admet-995	154	56	)	)	PUNCT
admet-995	154	57	diphenhydramine	diphenhydramine	NOUN
admet-995	154	58	,	,	PUNCT
admet-995	154	59	(	(	PUNCT
admet-995	154	60	10	10	NUM
admet-995	154	61	)	)	PUNCT
admet-995	154	62	desloratanide	desloratanide	NOUN
admet-995	154	63	,	,	PUNCT
admet-995	154	64	(	(	PUNCT
admet-995	154	65	11	11	NUM
admet-995	154	66	)	)	PUNCT
admet-995	154	67	spironolactone	spironolactone	NOUN
admet-995	154	68	,	,	PUNCT
admet-995	154	69	(	(	PUNCT
admet-995	154	70	12	12	NUM
admet-995	154	71	)	)	PUNCT
admet-995	154	72	metoprolol	metoprolol	PROPN
admet-995	154	73	,	,	PUNCT
admet-995	154	74	(	(	PUNCT
admet-995	154	75	13	13	NUM
admet-995	154	76	)	)	PUNCT
admet-995	154	77	lamotrigine	lamotrigine	NOUN
admet-995	154	78	,	,	PUNCT
admet-995	154	79	(	(	PUNCT
admet-995	154	80	14	14	NUM
admet-995	154	81	)	)	PUNCT
admet-995	154	82	indomethacin	indomethacin	NOUN
admet-995	154	83	,	,	PUNCT
admet-995	154	84	(	(	PUNCT
admet-995	154	85	15	15	X
admet-995	154	86	)	)	PUNCT
admet-995	154	87	trimethoprim	trimethoprim	NOUN
admet-995	154	88	,	,	PUNCT
admet-995	154	89	(	(	PUNCT
admet-995	154	90	16	16	NUM
admet-995	154	91	)	)	PUNCT
admet-995	154	92	alfuzosin	alfuzosin	NOUN
admet-995	154	93	.	.	PUNCT
admet-995	155	1	table	table	NOUN
admet-995	155	2	6	6	NUM
admet-995	155	3	.	.	PUNCT
admet-995	156	1	compounds	compound	NOUN
admet-995	156	2	selected	select	VERB
admet-995	156	3	for	for	ADP
admet-995	156	4	the	the	DET
admet-995	156	5	test	test	NOUN
admet-995	156	6	set	set	VERB
admet-995	156	7	and	and	CCONJ
admet-995	156	8	their	their	PRON
admet-995	156	9	indications	indication	NOUN
admet-995	156	10	.	.	PUNCT
admet-995	157	1	pharmaceutical	pharmaceutical	NOUN
admet-995	157	2	drug	drug	NOUN
admet-995	157	3	class	class	NOUN
admet-995	157	4	alfuzosin	alfuzosin	VERB
admet-995	157	5	alpha	alpha	PROPN
admet-995	157	6	blocker	blocker	PROPN
admet-995	157	7	desloratadine	desloratadine	PROPN
admet-995	157	8	tricyclic	tricyclic	PROPN
admet-995	157	9	antihistamine	antihistamine	PROPN
admet-995	157	10	diphenhydramine	diphenhydramine	PROPN
admet-995	157	11	antihistamine	antihistamine	PROPN
admet-995	157	12	dofetilide	dofetilide	PROPN
admet-995	157	13	class	class	PROPN
admet-995	157	14	iii	iii	NUM
admet-995	157	15	antiarrhythmic	antiarrhythmic	ADJ
admet-995	157	16	agent	agent	NOUN
admet-995	157	17	flecainide	flecainide	PROPN
admet-995	157	18	class	class	PROPN
admet-995	157	19	i	i	PRON
admet-995	157	20	antiarrhythmic	antiarrhythmic	ADJ
admet-995	157	21	agent	agent	NOUN
admet-995	157	22	fluoxetine	fluoxetine	NOUN
admet-995	157	23	selective	selective	ADJ
admet-995	157	24	serotonin	serotonin	NOUN
admet-995	157	25	reuptake	reuptake	NOUN
admet-995	157	26	inhibitor	inhibitor	NOUN
admet-995	157	27	(	(	PUNCT
admet-995	157	28	ssri	ssri	ADJ
admet-995	157	29	)	)	PUNCT
admet-995	157	30	antidepressant	antidepressant	NOUN
admet-995	157	31	indomethacin	indomethacin	VERB
admet-995	157	32	non	non	ADJ
admet-995	157	33	-	-	ADJ
admet-995	157	34	steroidal	steroidal	ADJ
admet-995	157	35	anti	anti	ADJ
admet-995	157	36	-	-	ADJ
admet-995	157	37	inflammatory	inflammatory	ADJ
admet-995	157	38	(	(	PUNCT
admet-995	157	39	nsaid	nsaid	PROPN
admet-995	157	40	)	)	PUNCT
admet-995	157	41	irbesartan	irbesartan	PROPN
admet-995	157	42	angiotensin	angiotensin	NOUN
admet-995	157	43	receptor	receptor	NOUN
admet-995	157	44	blocker	blocker	NOUN
admet-995	157	45	(	(	PUNCT
admet-995	157	46	arb	arb	NOUN
admet-995	157	47	)	)	PUNCT
admet-995	157	48	lamotrigine	lamotrigine	ADJ
admet-995	157	49	antiepileptic	antiepileptic	ADJ
admet-995	157	50	/	/	SYM
admet-995	157	51	anticonvulsant	anticonvulsant	ADJ
admet-995	157	52	metoprolol	metoprolol	PROPN
admet-995	157	53	class	class	PROPN
admet-995	157	54	ii	ii	PROPN
admet-995	157	55	antiarrhythmic	antiarrhythmic	ADJ
admet-995	157	56	agent	agent	NOUN
admet-995	157	57	protriptyline	protriptyline	NOUN
admet-995	157	58	tricyclic	tricyclic	ADJ
admet-995	157	59	antidepressant	antidepressant	ADJ
admet-995	157	60	sildenafil	sildenafil	NOUN
admet-995	157	61	phosphodiesterase	phosphodiesterase	NOUN
admet-995	157	62	(	(	PUNCT
admet-995	157	63	pde	pde	NOUN
admet-995	157	64	)	)	PUNCT
admet-995	157	65	inhibitor	inhibitor	NOUN
admet-995	157	66	spironolactone	spironolactone	NOUN
admet-995	157	67	aldosterone	aldosterone	NOUN
admet-995	157	68	antagonist	antagonist	NOUN
admet-995	157	69	trazodone	trazodone	NOUN
admet-995	157	70	serotonin	serotonin	NOUN
admet-995	157	71	antagonist	antagonist	NOUN
admet-995	157	72	and	and	CCONJ
admet-995	157	73	reuptake	reuptake	NOUN
admet-995	157	74	inhibitor	inhibitor	NOUN
admet-995	157	75	(	(	PUNCT
admet-995	157	76	sari	sari	NOUN
admet-995	157	77	)	)	PUNCT
admet-995	157	78	antidepressant	antidepressant	ADJ
admet-995	157	79	trimethoprim	trimethoprim	NOUN
admet-995	157	80	antibacterial	antibacterial	ADJ
admet-995	157	81	ziprasidone	ziprasidone	NOUN
admet-995	157	82	atypical	atypical	ADJ
admet-995	157	83	antipsychotic	antipsychotic	ADJ
admet-995	157	84	using	use	VERB
admet-995	157	85	stepwise	stepwise	PROPN
admet-995	157	86	regression	regression	NOUN
admet-995	157	87	analysis	analysis	NOUN
admet-995	157	88	on	on	ADP
admet-995	157	89	the	the	DET
admet-995	157	90	training	training	NOUN
admet-995	157	91	set	set	NOUN
admet-995	157	92	,	,	PUNCT
admet-995	157	93	a	a	DET
admet-995	157	94	model	model	NOUN
admet-995	157	95	was	be	AUX
admet-995	157	96	built	build	VERB
admet-995	157	97	using	use	VERB
admet-995	157	98	only	only	ADV
admet-995	157	99	the	the	DET
admet-995	157	100	measured	measured	ADJ
admet-995	157	101	properties	property	NOUN
admet-995	157	102	listed	list	VERB
admet-995	157	103	in	in	ADP
admet-995	157	104	table	table	NOUN
admet-995	157	105	4	4	NUM
admet-995	157	106	.	.	PUNCT
admet-995	158	1	the	the	DET
admet-995	158	2	best	good	ADJ
admet-995	158	3	model	model	NOUN
admet-995	158	4	can	can	AUX
admet-995	158	5	be	be	AUX
admet-995	158	6	described	describe	VERB
admet-995	158	7	by	by	ADP
admet-995	158	8	equation	equation	NOUN
admet-995	158	9	3	3	NUM
admet-995	158	10	:	:	PUNCT
admet-995	158	11	http://dx.doi.org/10.5599/admet.0000	http://dx.doi.org/10.5599/admet.0000	NUM
admet-995	158	12	stergiopoulos	stergiopoulos	PROPN
admet-995	158	13	,	,	PUNCT
admet-995	158	14	tsopelas	tsopela	NOUN
admet-995	158	15	and	and	CCONJ
admet-995	158	16	valko	valko	PROPN
admet-995	158	17	admet	admet	PROPN
admet-995	158	18	&	&	CCONJ
admet-995	158	19	dmpk	dmpk	PROPN
admet-995	158	20	9(3	9(3	NUM
admet-995	158	21	)	)	PUNCT
admet-995	158	22	(	(	PUNCT
admet-995	158	23	2021	2021	NUM
admet-995	158	24	)	)	PUNCT
admet-995	158	25	191	191	NUM
admet-995	158	26	-	-	SYM
admet-995	158	27	207	207	NUM
admet-995	158	28	202	202	NUM
admet-995	158	29	pic	pic	NOUN
admet-995	158	30	50	50	NUM
admet-995	158	31	=	=	SYM
admet-995	158	32	3.63(±0.37	3.63(±0.37	NUM
admet-995	158	33	)	)	PUNCT
admet-995	159	1	+	+	CCONJ
admet-995	159	2	0.88(±0.12)*log	0.88(±0.12)*log	PUNCT
admet-995	160	1	k	k	X
admet-995	160	2	agp	agp	PROPN
admet-995	161	1	+	+	CCONJ
admet-995	161	2	0.42(±0.18)*log	0.42(±0.18)*log	VERB
admet-995	161	3	k	k	PROPN
admet-995	161	4	iam	iam	PROPN
admet-995	161	5	(	(	PUNCT
admet-995	161	6	3	3	NUM
admet-995	161	7	)	)	PUNCT
admet-995	161	8	(	(	PUNCT
admet-995	161	9	r=0.850	r=0.850	NOUN
admet-995	161	10	,	,	PUNCT
admet-995	161	11	r	r	NOUN
admet-995	161	12	2	2	NUM
admet-995	161	13	=	=	NUM
admet-995	161	14	0.722	0.722	NUM
admet-995	161	15	,	,	PUNCT
admet-995	161	16	r	r	NOUN
admet-995	161	17	2	2	NUM
admet-995	161	18	adj=0.714	adj=0.714	PROPN
admet-995	161	19	,	,	PUNCT
admet-995	161	20	n=74	n=74	NOUN
admet-995	161	21	,	,	PUNCT
admet-995	161	22	s=0.553	s=0.553	PROPN
admet-995	161	23	,	,	PUNCT
admet-995	161	24	f=92.1	f=92.1	NOUN
admet-995	161	25	)	)	PUNCT
admet-995	161	26	r	r	NOUN
admet-995	161	27	is	be	AUX
admet-995	161	28	the	the	DET
admet-995	161	29	correlation	correlation	NOUN
admet-995	161	30	coefficient	coefficient	NOUN
admet-995	161	31	,	,	PUNCT
admet-995	161	32	n	n	PRON
admet-995	161	33	is	be	AUX
admet-995	161	34	the	the	DET
admet-995	161	35	number	number	NOUN
admet-995	161	36	of	of	ADP
admet-995	161	37	compounds	compound	NOUN
admet-995	161	38	,	,	PUNCT
admet-995	161	39	s	s	X
admet-995	161	40	is	be	AUX
admet-995	161	41	the	the	DET
admet-995	161	42	standard	standard	ADJ
admet-995	161	43	error	error	NOUN
admet-995	161	44	of	of	ADP
admet-995	161	45	the	the	DET
admet-995	161	46	estimate	estimate	NOUN
admet-995	161	47	,	,	PUNCT
admet-995	161	48	f	f	PROPN
admet-995	161	49	is	be	AUX
admet-995	161	50	the	the	DET
admet-995	161	51	fisher	fisher	PROPN
admet-995	161	52	test	test	NOUN
admet-995	161	53	value	value	NOUN
admet-995	161	54	.	.	PUNCT
admet-995	162	1	the	the	DET
admet-995	162	2	iam	iam	PROPN
admet-995	162	3	binding	bind	VERB
admet-995	162	4	and	and	CCONJ
admet-995	162	5	agp	agp	NOUN
admet-995	162	6	binding	bind	VERB
admet-995	162	7	variables	variable	NOUN
admet-995	162	8	are	be	AUX
admet-995	162	9	highly	highly	ADV
admet-995	162	10	significant	significant	ADJ
admet-995	162	11	and	and	CCONJ
admet-995	162	12	showed	show	VERB
admet-995	162	13	a	a	DET
admet-995	162	14	week	week	NOUN
admet-995	162	15	intercorrelation	intercorrelation	NOUN
admet-995	162	16	(	(	PUNCT
admet-995	162	17	r	r	NOUN
admet-995	162	18	2	2	NUM
admet-995	162	19	=	=	NOUN
admet-995	162	20	0.42	0.42	NUM
admet-995	162	21	)	)	PUNCT
admet-995	162	22	.	.	PUNCT
admet-995	163	1	therefore	therefore	ADV
admet-995	163	2	,	,	PUNCT
admet-995	163	3	the	the	DET
admet-995	163	4	equation	equation	NOUN
admet-995	163	5	was	be	AUX
admet-995	163	6	recalculated	recalculate	VERB
admet-995	163	7	using	use	VERB
admet-995	163	8	partial	partial	ADJ
admet-995	163	9	least	least	ADJ
admet-995	163	10	squares	square	NOUN
admet-995	163	11	regression	regression	NOUN
admet-995	163	12	(	(	PUNCT
admet-995	163	13	pls	pls	INTJ
admet-995	163	14	)	)	PUNCT
admet-995	163	15	and	and	CCONJ
admet-995	163	16	the	the	DET
admet-995	163	17	same	same	ADJ
admet-995	163	18	coefficients	coefficient	NOUN
admet-995	163	19	and	and	CCONJ
admet-995	163	20	intercept	intercept	NOUN
admet-995	163	21	were	be	AUX
admet-995	163	22	obtained	obtain	VERB
admet-995	163	23	.	.	PUNCT
admet-995	164	1	the	the	DET
admet-995	164	2	best	good	ADJ
admet-995	164	3	model	model	NOUN
admet-995	164	4	using	use	VERB
admet-995	164	5	only	only	ADV
admet-995	164	6	in	in	ADP
admet-995	164	7	silico	silico	NOUN
admet-995	164	8	calculated	calculate	VERB
admet-995	164	9	properties	property	NOUN
admet-995	164	10	,	,	PUNCT
admet-995	164	11	the	the	DET
admet-995	164	12	molecular	molecular	ADJ
admet-995	164	13	weight	weight	NOUN
admet-995	164	14	(	(	PUNCT
admet-995	164	15	mw	mw	PROPN
admet-995	164	16	)	)	PUNCT
admet-995	164	17	,	,	PUNCT
admet-995	164	18	the	the	DET
admet-995	164	19	number	number	NOUN
admet-995	164	20	of	of	ADP
admet-995	164	21	hbond	hbond	ADJ
admet-995	164	22	donors	donor	NOUN
admet-995	164	23	(	(	PUNCT
admet-995	164	24	hbd	hbd	PROPN
admet-995	164	25	)	)	PUNCT
admet-995	164	26	and	and	CCONJ
admet-995	164	27	acceptor	acceptor	NOUN
admet-995	164	28	groups	group	NOUN
admet-995	164	29	(	(	PUNCT
admet-995	164	30	hba	hba	NOUN
admet-995	164	31	)	)	PUNCT
admet-995	164	32	,	,	PUNCT
admet-995	164	33	the	the	DET
admet-995	164	34	polar	polar	ADJ
admet-995	164	35	surface	surface	NOUN
admet-995	164	36	(	(	PUNCT
admet-995	164	37	tpsa	tpsa	PROPN
admet-995	164	38	)	)	PUNCT
admet-995	164	39	,	,	PUNCT
admet-995	164	40	the	the	DET
admet-995	164	41	logarithm	logarithm	NOUN
admet-995	164	42	of	of	ADP
admet-995	164	43	the	the	DET
admet-995	164	44	calculated	calculate	VERB
admet-995	164	45	octanol	octanol	NOUN
admet-995	164	46	/	/	SYM
admet-995	164	47	water	water	NOUN
admet-995	164	48	partition	partition	NOUN
admet-995	164	49	coefficient	coefficient	NOUN
admet-995	164	50	of	of	ADP
admet-995	164	51	the	the	DET
admet-995	164	52	neutral	neutral	ADJ
admet-995	164	53	form	form	NOUN
admet-995	164	54	and	and	CCONJ
admet-995	164	55	the	the	DET
admet-995	164	56	combined	combine	VERB
admet-995	164	57	ionised	ionised	ADJ
admet-995	164	58	form	form	NOUN
admet-995	164	59	of	of	ADP
admet-995	164	60	the	the	DET
admet-995	164	61	molecules	molecule	NOUN
admet-995	164	62	at	at	ADP
admet-995	164	63	ph	ph	PROPN
admet-995	164	64	7.4	7.4	NUM
admet-995	164	65	(	(	PUNCT
admet-995	164	66	log	log	NOUN
admet-995	164	67	p	p	NOUN
admet-995	164	68	and	and	CCONJ
admet-995	164	69	log	log	VERB
admet-995	164	70	d	d	PROPN
admet-995	164	71	)	)	PUNCT
admet-995	164	72	,	,	PUNCT
admet-995	164	73	calculated	calculate	VERB
admet-995	164	74	fractions	fraction	NOUN
admet-995	164	75	of	of	ADP
admet-995	164	76	the	the	DET
admet-995	164	77	positive	positive	ADJ
admet-995	164	78	,	,	PUNCT
admet-995	164	79	negative	negative	ADJ
admet-995	164	80	and	and	CCONJ
admet-995	164	81	zwitterionic	zwitterionic	ADJ
admet-995	164	82	charges	charge	NOUN
admet-995	164	83	at	at	ADP
admet-995	164	84	physiological	physiological	ADJ
admet-995	164	85	ph	ph	NOUN
admet-995	164	86	(	(	PUNCT
admet-995	164	87	f+	f+	PROPN
admet-995	164	88	,	,	PUNCT
admet-995	164	89	f-	f-	NUM
admet-995	164	90	,	,	PUNCT
admet-995	164	91	fz	fz	NOUN
admet-995	164	92	)	)	PUNCT
admet-995	164	93	,	,	PUNCT
admet-995	164	94	and	and	CCONJ
admet-995	164	95	the	the	DET
admet-995	164	96	abraham	abraham	PROPN
admet-995	164	97	h	h	PROPN
admet-995	164	98	-	-	PUNCT
admet-995	164	99	bond	bond	NOUN
admet-995	164	100	acidity	acidity	NOUN
admet-995	164	101	and	and	CCONJ
admet-995	164	102	b	b	NOUN
admet-995	164	103	-	-	PUNCT
admet-995	164	104	bond	bond	NOUN
admet-995	164	105	basicity	basicity	NOUN
admet-995	164	106	parameters	parameter	NOUN
admet-995	164	107	(	(	PUNCT
admet-995	164	108	a	a	DET
admet-995	164	109	,	,	PUNCT
admet-995	164	110	b	b	NOUN
admet-995	164	111	)	)	PUNCT
admet-995	164	112	can	can	AUX
admet-995	164	113	be	be	AUX
admet-995	164	114	described	describe	VERB
admet-995	164	115	by	by	ADP
admet-995	164	116	equation	equation	NOUN
admet-995	164	117	4	4	NUM
admet-995	164	118	.	.	PUNCT
admet-995	165	1	pic50	pic50	NOUN
admet-995	165	2	=	=	SYM
admet-995	165	3	3.94(±0.17	3.94(±0.17	NOUN
admet-995	165	4	)	)	PUNCT
admet-995	166	1	+	+	CCONJ
admet-995	166	2	0.38(±0.05)*log	0.38(±0.05)*log	NOUN
admet-995	166	3	p	p	PROPN
admet-995	166	4	1.49(±0.51)*f(4	1.49(±0.51)*f(4	NUM
admet-995	166	5	)	)	PUNCT
admet-995	166	6	(	(	PUNCT
admet-995	166	7	r	r	NOUN
admet-995	166	8	=	=	SYM
admet-995	166	9	0.740	0.740	NUM
admet-995	166	10	,	,	PUNCT
admet-995	166	11	r2	r2	PROPN
admet-995	166	12	=	=	SYM
admet-995	166	13	0.547	0.547	NUM
admet-995	166	14	,	,	PUNCT
admet-995	166	15	r2	r2	NOUN
admet-995	166	16	ad	ad	NOUN
admet-995	166	17	j=	j=	NOUN
admet-995	166	18	0.534	0.534	NUM
admet-995	166	19	,	,	PUNCT
admet-995	166	20	n	n	PROPN
admet-995	166	21	=	=	SYM
admet-995	166	22	74	74	NUM
admet-995	166	23	,	,	PUNCT
admet-995	166	24	s	s	PART
admet-995	166	25	=	=	SYM
admet-995	166	26	0.706	0.706	NUM
admet-995	166	27	,	,	PUNCT
admet-995	166	28	f	f	PROPN
admet-995	166	29	=	=	SYM
admet-995	166	30	42.9	42.9	NUM
admet-995	166	31	)	)	PUNCT
admet-995	167	1	it	it	PRON
admet-995	167	2	was	be	AUX
admet-995	167	3	found	find	VERB
admet-995	167	4	that	that	SCONJ
admet-995	167	5	log	log	NOUN
admet-995	167	6	p	p	NOUN
admet-995	167	7	is	be	AUX
admet-995	167	8	correlated	correlate	VERB
admet-995	167	9	better	well	ADV
admet-995	167	10	than	than	ADP
admet-995	167	11	log	log	VERB
admet-995	167	12	d	d	PROPN
admet-995	167	13	with	with	ADP
admet-995	167	14	pic50	pic50	NOUN
admet-995	167	15	and	and	CCONJ
admet-995	167	16	only	only	ADV
admet-995	167	17	negatively	negatively	ADV
admet-995	167	18	charged	charge	VERB
admet-995	167	19	molecular	molecular	ADJ
admet-995	167	20	fraction	fraction	NOUN
admet-995	167	21	fstands	fstand	NOUN
admet-995	167	22	as	as	ADP
admet-995	167	23	statistically	statistically	ADV
admet-995	167	24	significant	significant	ADJ
admet-995	167	25	additional	additional	ADJ
admet-995	167	26	physicochemical	physicochemical	ADJ
admet-995	167	27	parameter	parameter	NOUN
admet-995	167	28	next	next	ADV
admet-995	167	29	to	to	PART
admet-995	167	30	log	log	VERB
admet-995	167	31	p.	p.	NOUN
admet-995	168	1	the	the	DET
admet-995	168	2	statistical	statistical	ADJ
admet-995	168	3	insignificance	insignificance	NOUN
admet-995	168	4	of	of	ADP
admet-995	168	5	f+	f+	NOUN
admet-995	168	6	may	may	AUX
admet-995	168	7	be	be	AUX
admet-995	168	8	attributed	attribute	VERB
admet-995	168	9	to	to	ADP
admet-995	168	10	the	the	DET
admet-995	168	11	fact	fact	NOUN
admet-995	168	12	that	that	SCONJ
admet-995	168	13	its	its	PRON
admet-995	168	14	positive	positive	ADJ
admet-995	168	15	sign	sign	NOUN
admet-995	168	16	due	due	ADP
admet-995	168	17	to	to	ADP
admet-995	168	18	ionization	ionization	NOUN
admet-995	168	19	counterbalanced	counterbalance	VERB
admet-995	168	20	with	with	ADP
admet-995	168	21	its	its	PRON
admet-995	168	22	positive	positive	ADJ
admet-995	168	23	influence	influence	NOUN
admet-995	168	24	to	to	ADP
admet-995	168	25	pic50	pic50	NOUN
admet-995	168	26	.	.	PUNCT
admet-995	169	1	the	the	DET
admet-995	169	2	models	model	NOUN
admet-995	169	3	'	'	PART
admet-995	169	4	statistical	statistical	ADJ
admet-995	169	5	parameters	parameter	NOUN
admet-995	169	6	are	be	AUX
admet-995	169	7	much	much	ADV
admet-995	169	8	worse	bad	ADJ
admet-995	169	9	when	when	SCONJ
admet-995	169	10	compared	compare	VERB
admet-995	169	11	to	to	ADP
admet-995	169	12	the	the	DET
admet-995	169	13	model	model	NOUN
admet-995	169	14	using	use	VERB
admet-995	169	15	measured	measure	VERB
admet-995	169	16	agp	agp	NOUN
admet-995	169	17	binding	bind	VERB
admet-995	169	18	(	(	PUNCT
admet-995	169	19	log	log	PROPN
admet-995	169	20	k	k	PROPN
admet-995	169	21	agp	agp	PROPN
admet-995	169	22	)	)	PUNCT
admet-995	169	23	data	datum	NOUN
admet-995	169	24	and	and	CCONJ
admet-995	169	25	membrane	membrane	NOUN
admet-995	169	26	partition	partition	NOUN
admet-995	169	27	(	(	PUNCT
admet-995	169	28	log	log	NOUN
admet-995	169	29	k	k	PROPN
admet-995	169	30	iam	iam	PROPN
admet-995	169	31	)	)	PUNCT
admet-995	169	32	data	datum	NOUN
admet-995	169	33	.	.	PUNCT
admet-995	170	1	the	the	DET
admet-995	170	2	estimated	estimate	VERB
admet-995	170	3	pic50	pic50	ADJ
admet-995	170	4	values	value	NOUN
admet-995	170	5	of	of	ADP
admet-995	170	6	the	the	DET
admet-995	170	7	test	test	NOUN
admet-995	170	8	set	set	NOUN
admet-995	170	9	have	have	AUX
admet-995	170	10	been	be	AUX
admet-995	170	11	calculated	calculate	VERB
admet-995	170	12	using	use	VERB
admet-995	170	13	equation	equation	NOUN
admet-995	170	14	3	3	NUM
admet-995	170	15	and	and	CCONJ
admet-995	170	16	plotted	plot	VERB
admet-995	170	17	in	in	ADP
admet-995	170	18	figure	figure	NOUN
admet-995	170	19	2	2	NUM
admet-995	170	20	.	.	PUNCT
admet-995	171	1	the	the	DET
admet-995	171	2	test	test	NOUN
admet-995	171	3	set	set	VERB
admet-995	171	4	compounds	compound	NOUN
admet-995	171	5	are	be	AUX
admet-995	171	6	marked	mark	VERB
admet-995	171	7	with	with	ADP
admet-995	171	8	larger	large	ADJ
admet-995	171	9	circles	circle	NOUN
admet-995	171	10	.	.	PUNCT
admet-995	172	1	figure	figure	NOUN
admet-995	172	2	2	2	NUM
admet-995	172	3	shows	show	VERB
admet-995	172	4	the	the	DET
admet-995	172	5	literature	literature	NOUN
admet-995	172	6	herg	herg	PROPN
admet-995	172	7	pic50	pic50	PROPN
admet-995	172	8	data	datum	NOUN
admet-995	172	9	and	and	CCONJ
admet-995	172	10	the	the	DET
admet-995	172	11	back	back	ADV
admet-995	172	12	-	-	PUNCT
admet-995	172	13	calculated	calculate	VERB
admet-995	172	14	pic50	pic50	NOUN
admet-995	172	15	data	datum	NOUN
admet-995	172	16	using	use	VERB
admet-995	172	17	equation	equation	NOUN
admet-995	172	18	3	3	NUM
admet-995	172	19	.	.	PUNCT
admet-995	173	1	blue	blue	ADJ
admet-995	173	2	circles	circle	NOUN
admet-995	173	3	mark	mark	VERB
admet-995	173	4	positively	positively	ADV
admet-995	173	5	charged	charge	VERB
admet-995	173	6	compounds	compound	NOUN
admet-995	173	7	at	at	ADP
admet-995	173	8	ph	ph	PROPN
admet-995	173	9	7.4	7.4	NUM
admet-995	173	10	;	;	PUNCT
admet-995	173	11	red	red	ADJ
admet-995	173	12	circles	circle	NOUN
admet-995	173	13	mark	mark	VERB
admet-995	173	14	negatively	negatively	ADV
admet-995	173	15	charged	charge	VERB
admet-995	173	16	compounds	compound	NOUN
admet-995	173	17	at	at	ADP
admet-995	173	18	ph7.4	ph7.4	PROPN
admet-995	173	19	.	.	PUNCT
admet-995	174	1	the	the	DET
admet-995	174	2	green	green	PROPN
admet-995	174	3	circles	circle	NOUN
admet-995	174	4	mark	mark	VERB
admet-995	174	5	neutral	neutral	ADJ
admet-995	174	6	compounds	compound	NOUN
admet-995	174	7	at	at	ADP
admet-995	174	8	ph	ph	PROPN
admet-995	174	9	7.4	7.4	NUM
admet-995	174	10	;	;	PUNCT
admet-995	174	11	green	green	PROPN
admet-995	174	12	circle	circle	PROPN
admet-995	174	13	's	's	PART
admet-995	174	14	shade	shade	NOUN
admet-995	174	15	reflects	reflect	VERB
admet-995	174	16	the	the	DET
admet-995	174	17	presence	presence	NOUN
admet-995	174	18	of	of	ADP
admet-995	174	19	weak	weak	ADJ
admet-995	174	20	acidic	acidic	ADJ
admet-995	174	21	(	(	PUNCT
admet-995	174	22	lighter	light	ADJ
admet-995	174	23	green	green	NOUN
admet-995	174	24	)	)	PUNCT
admet-995	174	25	or	or	CCONJ
admet-995	174	26	weak	weak	ADJ
admet-995	174	27	basic	basic	ADJ
admet-995	174	28	(	(	PUNCT
admet-995	174	29	darker	dark	ADJ
admet-995	174	30	green	green	ADJ
admet-995	174	31	)	)	PUNCT
admet-995	174	32	groups	group	NOUN
admet-995	174	33	in	in	ADP
admet-995	174	34	the	the	DET
admet-995	174	35	molecules	molecule	NOUN
admet-995	174	36	;	;	PUNCT
admet-995	174	37	purple	purple	ADJ
admet-995	174	38	circles	circle	NOUN
admet-995	174	39	indicate	indicate	VERB
admet-995	174	40	compounds	compound	NOUN
admet-995	174	41	with	with	ADP
admet-995	174	42	zwitterionic	zwitterionic	ADJ
admet-995	174	43	character	character	NOUN
admet-995	174	44	at	at	ADP
admet-995	174	45	ph	ph	PROPN
admet-995	174	46	7.4	7.4	NUM
admet-995	174	47	admet	admet	NOUN
admet-995	174	48	&	&	CCONJ
admet-995	174	49	dmpk	dmpk	PROPN
admet-995	174	50	9(3	9(3	NUM
admet-995	174	51	)	)	PUNCT
admet-995	174	52	(	(	PUNCT
admet-995	174	53	2021	2021	NUM
admet-995	174	54	)	)	PUNCT
admet-995	174	55	191	191	NUM
admet-995	174	56	-	-	SYM
admet-995	174	57	207	207	NUM
admet-995	174	58	prediction	prediction	NOUN
admet-995	174	59	of	of	ADP
admet-995	174	60	herg	herg	PROPN
admet-995	174	61	inhibition	inhibition	NOUN
admet-995	174	62	by	by	ADP
admet-995	174	63	biomimetic	biomimetic	ADJ
admet-995	174	64	measurements	measurement	NOUN
admet-995	174	65	doi	doi	NOUN
admet-995	174	66	:	:	PUNCT
admet-995	174	67	http://dx.doi.org/10.5599/admet.995	http://dx.doi.org/10.5599/admet.995	ADJ
admet-995	174	68	203	203	NUM
admet-995	174	69	it	it	PRON
admet-995	174	70	can	can	AUX
admet-995	174	71	be	be	AUX
admet-995	174	72	seen	see	VERB
admet-995	174	73	in	in	ADP
admet-995	174	74	figure	figure	NOUN
admet-995	174	75	2	2	NUM
admet-995	174	76	that	that	SCONJ
admet-995	174	77	the	the	DET
admet-995	174	78	majority	majority	NOUN
admet-995	174	79	of	of	ADP
admet-995	174	80	the	the	DET
admet-995	174	81	positively	positively	ADV
admet-995	174	82	charged	charge	VERB
admet-995	174	83	compounds	compound	NOUN
admet-995	174	84	show	show	VERB
admet-995	174	85	a	a	DET
admet-995	174	86	pic50	pic50	NOUN
admet-995	174	87	value	value	NOUN
admet-995	174	88	greater	great	ADJ
admet-995	174	89	than	than	ADP
admet-995	174	90	5	5	NUM
admet-995	174	91	log	log	NOUN
admet-995	174	92	units	unit	NOUN
admet-995	174	93	in	in	ADP
admet-995	174	94	the	the	DET
admet-995	174	95	in	in	NOUN
admet-995	174	96	vitro	vitro	X
admet-995	174	97	herg	herg	PROPN
admet-995	174	98	experiments	experiment	NOUN
admet-995	174	99	.	.	PUNCT
admet-995	175	1	acidic	acidic	ADJ
admet-995	175	2	and	and	CCONJ
admet-995	175	3	zwitterionic	zwitterionic	ADJ
admet-995	175	4	compounds	compound	NOUN
admet-995	175	5	show	show	VERB
admet-995	175	6	only	only	ADV
admet-995	175	7	weak	weak	ADJ
admet-995	175	8	herg	herg	NOUN
admet-995	175	9	inhibition	inhibition	NOUN
admet-995	175	10	.	.	PUNCT
admet-995	176	1	it	it	PRON
admet-995	176	2	is	be	AUX
admet-995	176	3	also	also	ADV
admet-995	176	4	interesting	interesting	ADJ
admet-995	176	5	to	to	PART
admet-995	176	6	note	note	VERB
admet-995	176	7	that	that	SCONJ
admet-995	176	8	the	the	DET
admet-995	176	9	agp	agp	NOUN
admet-995	176	10	binding	bind	VERB
admet-995	176	11	data	datum	NOUN
admet-995	176	12	showed	show	VERB
admet-995	176	13	a	a	DET
admet-995	176	14	strong	strong	ADJ
admet-995	176	15	correlation	correlation	NOUN
admet-995	176	16	with	with	ADP
admet-995	176	17	the	the	DET
admet-995	176	18	compounds	compound	NOUN
admet-995	176	19	binding	bind	VERB
admet-995	176	20	to	to	ADP
admet-995	176	21	herg	herg	PROPN
admet-995	176	22	channel	channel	NOUN
admet-995	176	23	receptors	receptor	NOUN
admet-995	176	24	.	.	PUNCT
admet-995	177	1	the	the	DET
admet-995	177	2	explanation	explanation	NOUN
admet-995	177	3	for	for	ADP
admet-995	177	4	this	this	PRON
admet-995	177	5	may	may	AUX
admet-995	177	6	lie	lie	VERB
admet-995	177	7	in	in	ADP
admet-995	177	8	the	the	DET
admet-995	177	9	similarity	similarity	NOUN
admet-995	177	10	of	of	ADP
admet-995	177	11	the	the	DET
admet-995	177	12	two	two	NUM
admet-995	177	13	proteins	protein	NOUN
admet-995	177	14	.	.	PUNCT
admet-995	178	1	it	it	PRON
admet-995	178	2	was	be	AUX
admet-995	178	3	found	find	VERB
admet-995	178	4	[	[	X
admet-995	178	5	38	38	NUM
admet-995	178	6	]	]	PUNCT
admet-995	178	7	that	that	SCONJ
admet-995	178	8	the	the	DET
admet-995	178	9	agp	agp	NOUN
admet-995	178	10	binding	bind	VERB
admet-995	178	11	site	site	NOUN
admet-995	178	12	can	can	AUX
admet-995	178	13	be	be	AUX
admet-995	178	14	featured	feature	VERB
admet-995	178	15	as	as	ADP
admet-995	178	16	a	a	DET
admet-995	178	17	funnel	funnel	NOUN
admet-995	178	18	-	-	PUNCT
admet-995	178	19	like	like	ADJ
admet-995	178	20	structure	structure	NOUN
admet-995	178	21	.	.	PUNCT
admet-995	179	1	the	the	DET
admet-995	179	2	side	side	NOUN
admet-995	179	3	of	of	ADP
admet-995	179	4	the	the	DET
admet-995	179	5	funnel	funnel	NOUN
admet-995	179	6	represents	represent	VERB
admet-995	179	7	a	a	DET
admet-995	179	8	lipophilic	lipophilic	ADJ
admet-995	179	9	region	region	NOUN
admet-995	179	10	.	.	PUNCT
admet-995	180	1	the	the	DET
admet-995	180	2	funnel	funnel	NOUN
admet-995	180	3	's	's	PART
admet-995	180	4	top	top	ADJ
admet-995	180	5	width	width	NOUN
admet-995	180	6	provides	provide	VERB
admet-995	180	7	a	a	DET
admet-995	180	8	steric	steric	ADJ
admet-995	180	9	hindrance	hindrance	NOUN
admet-995	180	10	for	for	ADP
admet-995	180	11	molecules	molecule	NOUN
admet-995	180	12	wider	wide	ADJ
admet-995	180	13	than	than	ADP
admet-995	180	14	the	the	DET
admet-995	180	15	funnel	funnel	NOUN
admet-995	180	16	,	,	PUNCT
admet-995	180	17	while	while	SCONJ
admet-995	180	18	at	at	ADP
admet-995	180	19	the	the	DET
admet-995	180	20	narrow	narrow	ADJ
admet-995	180	21	end	end	NOUN
admet-995	180	22	of	of	ADP
admet-995	180	23	the	the	DET
admet-995	180	24	funnel	funnel	NOUN
admet-995	180	25	are	be	AUX
admet-995	180	26	the	the	DET
admet-995	180	27	negatively	negatively	ADV
admet-995	180	28	charged	charge	VERB
admet-995	180	29	sialic	sialic	ADJ
admet-995	180	30	acid	acid	NOUN
admet-995	180	31	residues	residue	NOUN
admet-995	180	32	that	that	PRON
admet-995	180	33	bind	bind	VERB
admet-995	180	34	the	the	DET
admet-995	180	35	positive	positive	ADJ
admet-995	180	36	charges	charge	NOUN
admet-995	180	37	if	if	SCONJ
admet-995	180	38	they	they	PRON
admet-995	180	39	fit	fit	VERB
admet-995	180	40	into	into	ADP
admet-995	180	41	the	the	DET
admet-995	180	42	deep	deep	ADJ
admet-995	180	43	end	end	NOUN
admet-995	180	44	of	of	ADP
admet-995	180	45	the	the	DET
admet-995	180	46	funnel	funnel	NOUN
admet-995	180	47	.	.	PUNCT
admet-995	181	1	the	the	DET
admet-995	181	2	structure	structure	NOUN
admet-995	181	3	is	be	AUX
admet-995	181	4	illustrated	illustrate	VERB
admet-995	181	5	in	in	ADP
admet-995	181	6	figure	figure	NOUN
admet-995	181	7	3	3	NUM
admet-995	181	8	.	.	PUNCT
admet-995	182	1	the	the	DET
admet-995	182	2	iam	iam	PROPN
admet-995	182	3	binding	binding	PROPN
admet-995	182	4	,	,	PUNCT
admet-995	182	5	which	which	PRON
admet-995	182	6	shows	show	VERB
admet-995	182	7	the	the	DET
admet-995	182	8	compound	compound	NOUN
admet-995	182	9	's	's	PART
admet-995	182	10	membrane	membrane	NOUN
admet-995	182	11	partition	partition	NOUN
admet-995	182	12	,	,	PUNCT
admet-995	182	13	was	be	AUX
admet-995	182	14	also	also	ADV
admet-995	182	15	significant	significant	ADJ
admet-995	182	16	in	in	ADP
admet-995	182	17	the	the	DET
admet-995	182	18	model	model	NOUN
admet-995	182	19	,	,	PUNCT
admet-995	182	20	which	which	PRON
admet-995	182	21	is	be	AUX
admet-995	182	22	not	not	PART
admet-995	182	23	surprising	surprising	ADJ
admet-995	182	24	as	as	SCONJ
admet-995	182	25	the	the	DET
admet-995	182	26	ion	ion	NOUN
admet-995	182	27	channel	channel	NOUN
admet-995	182	28	receptor	receptor	NOUN
admet-995	182	29	is	be	AUX
admet-995	182	30	in	in	ADP
admet-995	182	31	the	the	DET
admet-995	182	32	membrane	membrane	NOUN
admet-995	182	33	.	.	PUNCT
admet-995	183	1	the	the	DET
admet-995	183	2	compound	compound	NOUN
admet-995	183	3	needs	need	VERB
admet-995	183	4	to	to	PART
admet-995	183	5	have	have	VERB
admet-995	183	6	high	high	ADJ
admet-995	183	7	membrane	membrane	NOUN
admet-995	183	8	affinity	affinity	NOUN
admet-995	183	9	to	to	PART
admet-995	183	10	be	be	AUX
admet-995	183	11	able	able	ADJ
admet-995	183	12	to	to	PART
admet-995	183	13	approach	approach	VERB
admet-995	183	14	the	the	DET
admet-995	183	15	channel	channel	NOUN
admet-995	183	16	.	.	PUNCT
admet-995	184	1	the	the	DET
admet-995	184	2	positive	positive	ADJ
admet-995	184	3	charge	charge	NOUN
admet-995	184	4	also	also	ADV
admet-995	184	5	promotes	promote	VERB
admet-995	184	6	the	the	DET
admet-995	184	7	binding	binding	NOUN
admet-995	184	8	to	to	ADP
admet-995	184	9	the	the	DET
admet-995	184	10	negatively	negatively	ADV
admet-995	184	11	charged	charge	VERB
admet-995	184	12	surface	surface	NOUN
admet-995	184	13	.	.	PUNCT
admet-995	185	1	both	both	CCONJ
admet-995	185	2	the	the	DET
admet-995	185	3	agp	agp	PROPN
admet-995	185	4	and	and	CCONJ
admet-995	185	5	iam	iam	PROPN
admet-995	185	6	stationary	stationary	ADJ
admet-995	185	7	phases	phase	NOUN
admet-995	185	8	show	show	VERB
admet-995	185	9	strong	strong	ADJ
admet-995	185	10	shape	shape	NOUN
admet-995	185	11	selectivity	selectivity	NOUN
admet-995	185	12	,	,	PUNCT
admet-995	185	13	which	which	PRON
admet-995	185	14	is	be	AUX
admet-995	185	15	also	also	ADV
admet-995	185	16	essential	essential	ADJ
admet-995	185	17	to	to	ADP
admet-995	185	18	herg	herg	PROPN
admet-995	185	19	inhibition	inhibition	NOUN
admet-995	185	20	.	.	PUNCT
admet-995	186	1	although	although	SCONJ
admet-995	186	2	a	a	DET
admet-995	186	3	wide	wide	ADJ
admet-995	186	4	variety	variety	NOUN
admet-995	186	5	of	of	ADP
admet-995	186	6	molecules	molecule	NOUN
admet-995	186	7	show	show	VERB
admet-995	186	8	high	high	ADJ
admet-995	186	9	pic50	pic50	NOUN
admet-995	186	10	values	value	NOUN
admet-995	186	11	the	the	DET
admet-995	186	12	shape	shape	NOUN
admet-995	186	13	of	of	ADP
admet-995	186	14	the	the	DET
admet-995	186	15	molecule	molecule	NOUN
admet-995	186	16	is	be	AUX
admet-995	186	17	very	very	ADV
admet-995	186	18	important	important	ADJ
admet-995	186	19	because	because	SCONJ
admet-995	186	20	of	of	ADP
admet-995	186	21	the	the	DET
admet-995	186	22	channel	channel	NOUN
admet-995	186	23	opening	opening	NOUN
admet-995	186	24	's	's	PART
admet-995	186	25	well	well	ADV
admet-995	186	26	-	-	PUNCT
admet-995	186	27	defined	define	VERB
admet-995	186	28	size	size	NOUN
admet-995	186	29	.	.	PUNCT
admet-995	187	1	this	this	DET
admet-995	187	2	fact	fact	NOUN
admet-995	187	3	reduces	reduce	VERB
admet-995	187	4	the	the	DET
admet-995	187	5	power	power	NOUN
admet-995	187	6	of	of	ADP
admet-995	187	7	the	the	DET
admet-995	187	8	in	in	ADP
admet-995	187	9	silico	silico	NOUN
admet-995	187	10	models	model	NOUN
admet-995	187	11	if	if	SCONJ
admet-995	187	12	only	only	ADV
admet-995	187	13	2d	2d	NUM
admet-995	187	14	descriptors	descriptor	NOUN
admet-995	187	15	are	be	AUX
admet-995	187	16	used	use	VERB
admet-995	187	17	in	in	ADP
admet-995	187	18	the	the	DET
admet-995	187	19	model	model	NOUN
admet-995	187	20	building	building	NOUN
admet-995	187	21	.	.	PUNCT
admet-995	188	1	as	as	ADP
admet-995	188	2	a	a	DET
admet-995	188	3	result	result	NOUN
admet-995	188	4	,	,	PUNCT
admet-995	188	5	the	the	DET
admet-995	188	6	3d	3d	ADJ
admet-995	188	7	description	description	NOUN
admet-995	188	8	of	of	ADP
admet-995	188	9	the	the	DET
admet-995	188	10	molecules	molecule	NOUN
admet-995	188	11	would	would	AUX
admet-995	188	12	probably	probably	ADV
admet-995	188	13	enhance	enhance	VERB
admet-995	188	14	the	the	DET
admet-995	188	15	success	success	NOUN
admet-995	188	16	of	of	ADP
admet-995	188	17	in	in	ADP
admet-995	188	18	silico	silico	NOUN
admet-995	188	19	models	model	NOUN
admet-995	188	20	.	.	PUNCT
admet-995	189	1	agp	agp	NOUN
admet-995	189	2	binding	bind	VERB
admet-995	189	3	herg	herg	PROPN
admet-995	189	4	k	k	PROPN
admet-995	189	5	+	+	CCONJ
admet-995	189	6	ion	ion	NOUN
admet-995	189	7	-	-	PUNCT
admet-995	189	8	channel	channel	NOUN
admet-995	189	9	blockage	blockage	NOUN
admet-995	189	10	figure	figure	NOUN
admet-995	189	11	3	3	NUM
admet-995	189	12	.	.	PUNCT
admet-995	190	1	the	the	DET
admet-995	190	2	similarity	similarity	NOUN
admet-995	190	3	of	of	ADP
admet-995	190	4	the	the	DET
admet-995	190	5	binding	bind	VERB
admet-995	190	6	region	region	NOUN
admet-995	190	7	of	of	ADP
admet-995	190	8	agp	agp	PROPN
admet-995	190	9	and	and	CCONJ
admet-995	190	10	herg	herg	PROPN
admet-995	190	11	potassium	potassium	NOUN
admet-995	190	12	ion	ion	NOUN
admet-995	190	13	channels	channel	NOUN
admet-995	190	14	.	.	PUNCT
admet-995	191	1	the	the	DET
admet-995	191	2	steric	steric	ADJ
admet-995	191	3	structure	structure	NOUN
admet-995	191	4	and	and	CCONJ
admet-995	191	5	the	the	DET
admet-995	191	6	negatively	negatively	ADV
admet-995	191	7	charged	charge	VERB
admet-995	191	8	surface	surface	NOUN
admet-995	191	9	of	of	ADP
admet-995	191	10	agp	agp	NOUN
admet-995	191	11	and	and	CCONJ
admet-995	191	12	the	the	DET
admet-995	191	13	herg	herg	PROPN
admet-995	191	14	ion	ion	NOUN
admet-995	191	15	channel	channel	NOUN
admet-995	191	16	suggest	suggest	VERB
admet-995	191	17	strong	strong	ADJ
admet-995	191	18	similarities	similarity	NOUN
admet-995	191	19	.	.	PUNCT
admet-995	192	1	compounds	compound	NOUN
admet-995	192	2	that	that	PRON
admet-995	192	3	block	block	VERB
admet-995	192	4	the	the	DET
admet-995	192	5	channel	channel	NOUN
admet-995	192	6	have	have	VERB
admet-995	192	7	to	to	PART
admet-995	192	8	penetrate	penetrate	VERB
admet-995	192	9	the	the	DET
admet-995	192	10	cell	cell	NOUN
admet-995	192	11	and	and	CCONJ
admet-995	192	12	have	have	VERB
admet-995	192	13	a	a	DET
admet-995	192	14	relatively	relatively	ADV
admet-995	192	15	high	high	ADJ
admet-995	192	16	concentration	concentration	NOUN
admet-995	192	17	in	in	ADP
admet-995	192	18	the	the	DET
admet-995	192	19	cell	cell	NOUN
admet-995	192	20	membrane	membrane	NOUN
admet-995	192	21	where	where	SCONJ
admet-995	192	22	the	the	DET
admet-995	192	23	potassium	potassium	NOUN
admet-995	192	24	ion	ion	NOUN
admet-995	192	25	channel	channel	NOUN
admet-995	192	26	can	can	AUX
admet-995	192	27	be	be	AUX
admet-995	192	28	found	find	VERB
admet-995	192	29	[	[	X
admet-995	192	30	39	39	NUM
admet-995	192	31	]	]	PUNCT
admet-995	192	32	.	.	PUNCT
admet-995	193	1	this	this	PRON
admet-995	193	2	explains	explain	VERB
admet-995	193	3	the	the	DET
admet-995	193	4	importance	importance	NOUN
admet-995	193	5	of	of	ADP
admet-995	193	6	the	the	DET
admet-995	193	7	membrane	membrane	NOUN
admet-995	193	8	-	-	PUNCT
admet-995	193	9	binding	bind	VERB
admet-995	193	10	properties	property	NOUN
admet-995	193	11	in	in	ADP
admet-995	193	12	the	the	DET
admet-995	193	13	model	model	NOUN
admet-995	193	14	,	,	PUNCT
admet-995	193	15	as	as	SCONJ
admet-995	193	16	shown	show	VERB
admet-995	193	17	in	in	ADP
admet-995	193	18	figure	figure	NOUN
admet-995	193	19	4	4	NUM
admet-995	193	20	.	.	PUNCT
admet-995	194	1	validation	validation	NOUN
admet-995	194	2	of	of	ADP
admet-995	194	3	both	both	DET
admet-995	194	4	models	model	NOUN
admet-995	194	5	was	be	AUX
admet-995	194	6	performed	perform	VERB
admet-995	194	7	by	by	ADP
admet-995	194	8	predictions	prediction	NOUN
admet-995	194	9	of	of	ADP
admet-995	194	10	the	the	DET
admet-995	194	11	16	16	NUM
admet-995	194	12	compounds	compound	NOUN
admet-995	194	13	included	include	VERB
admet-995	194	14	in	in	ADP
admet-995	194	15	the	the	DET
admet-995	194	16	test	test	NOUN
admet-995	194	17	set	set	NOUN
admet-995	194	18	.	.	PUNCT
admet-995	195	1	the	the	DET
admet-995	195	2	results	result	NOUN
admet-995	195	3	are	be	AUX
admet-995	195	4	presented	present	VERB
admet-995	195	5	in	in	ADP
admet-995	195	6	table	table	NOUN
admet-995	195	7	7	7	NUM
admet-995	195	8	.	.	PUNCT
admet-995	196	1	it	it	PRON
admet-995	196	2	can	can	AUX
admet-995	196	3	be	be	AUX
admet-995	196	4	seen	see	VERB
admet-995	196	5	that	that	SCONJ
admet-995	196	6	the	the	DET
admet-995	196	7	prediction	prediction	NOUN
admet-995	196	8	of	of	ADP
admet-995	196	9	the	the	DET
admet-995	196	10	test	test	NOUN
admet-995	196	11	set	set	NOUN
admet-995	196	12	was	be	AUX
admet-995	196	13	superior	superior	ADJ
admet-995	196	14	in	in	ADP
admet-995	196	15	the	the	DET
admet-995	196	16	case	case	NOUN
admet-995	196	17	of	of	ADP
admet-995	196	18	the	the	DET
admet-995	196	19	model	model	NOUN
admet-995	196	20	derived	derive	VERB
admet-995	196	21	with	with	ADP
admet-995	196	22	the	the	DET
admet-995	196	23	measured	measured	ADJ
admet-995	196	24	properties	property	NOUN
admet-995	196	25	,	,	PUNCT
admet-995	196	26	and	and	CCONJ
admet-995	196	27	the	the	DET
admet-995	196	28	residuals	residual	NOUN
admet-995	196	29	did	do	AUX
admet-995	196	30	not	not	PART
admet-995	196	31	exceed	exceed	VERB
admet-995	196	32	double	double	DET
admet-995	196	33	the	the	DET
admet-995	196	34	model	model	NOUN
admet-995	196	35	error	error	NOUN
admet-995	196	36	(	(	PUNCT
admet-995	196	37	0.693	0.693	NUM
admet-995	196	38	)	)	PUNCT
admet-995	196	39	.	.	PUNCT
admet-995	197	1	on	on	ADP
admet-995	197	2	the	the	DET
admet-995	197	3	other	other	ADJ
admet-995	197	4	hand	hand	NOUN
admet-995	197	5	,	,	PUNCT
admet-995	197	6	predictions	prediction	NOUN
admet-995	197	7	from	from	ADP
admet-995	197	8	the	the	DET
admet-995	197	9	model	model	NOUN
admet-995	197	10	derived	derive	VERB
admet-995	197	11	with	with	ADP
admet-995	197	12	the	the	DET
admet-995	197	13	calculated	calculate	VERB
admet-995	197	14	properties	property	NOUN
admet-995	197	15	exhibited	exhibit	VERB
admet-995	197	16	much	much	ADV
admet-995	197	17	worse	bad	ADJ
admet-995	197	18	residuals	residual	NOUN
admet-995	197	19	in	in	ADP
admet-995	197	20	most	most	ADJ
admet-995	197	21	cases	case	NOUN
admet-995	197	22	,	,	PUNCT
admet-995	197	23	with	with	ADP
admet-995	197	24	the	the	DET
admet-995	197	25	pic50	pic50	ADJ
admet-995	197	26	predictions	prediction	NOUN
admet-995	197	27	of	of	ADP
admet-995	197	28	irbesartan	irbesartan	PROPN
admet-995	197	29	and	and	CCONJ
admet-995	197	30	lamotrigine	lamotrigine	NOUN
admet-995	197	31	exceeding	exceed	VERB
admet-995	197	32	1	1	NUM
admet-995	197	33	log	log	NOUN
admet-995	197	34	unit	unit	NOUN
admet-995	197	35	.	.	PUNCT
admet-995	198	1	http://dx.doi.org/10.5599/admet.0000	http://dx.doi.org/10.5599/admet.0000	PROPN
admet-995	198	2	stergiopoulos	stergiopoulos	PROPN
admet-995	198	3	,	,	PUNCT
admet-995	198	4	tsopelas	tsopela	NOUN
admet-995	198	5	and	and	CCONJ
admet-995	198	6	valko	valko	PROPN
admet-995	198	7	admet	admet	PROPN
admet-995	198	8	&	&	CCONJ
admet-995	198	9	dmpk	dmpk	PROPN
admet-995	198	10	9(3	9(3	NUM
admet-995	198	11	)	)	PUNCT
admet-995	198	12	(	(	PUNCT
admet-995	198	13	2021	2021	NUM
admet-995	198	14	)	)	PUNCT
admet-995	198	15	191	191	NUM
admet-995	198	16	-	-	SYM
admet-995	198	17	207	207	NUM
admet-995	198	18	204	204	NUM
admet-995	198	19	figure	figure	NOUN
admet-995	198	20	4	4	NUM
admet-995	198	21	.	.	PUNCT
admet-995	199	1	drug	drug	NOUN
admet-995	199	2	trapping	trap	VERB
admet-995	199	3	within	within	ADP
admet-995	199	4	the	the	DET
admet-995	199	5	k1	k1	PROPN
admet-995	199	6	channel	channel	NOUN
admet-995	199	7	vestibule	vestibule	NOUN
admet-995	199	8	.	.	PUNCT
admet-995	199	9	table	table	NOUN
admet-995	199	10	7	7	NUM
admet-995	199	11	.	.	PUNCT
admet-995	200	1	the	the	DET
admet-995	200	2	experimental	experimental	ADJ
admet-995	200	3	and	and	CCONJ
admet-995	200	4	the	the	DET
admet-995	200	5	predicted	predict	VERB
admet-995	200	6	pic50	pic50	ADJ
admet-995	200	7	values	value	NOUN
admet-995	200	8	of	of	ADP
admet-995	200	9	the	the	DET
admet-995	200	10	test	test	NOUN
admet-995	200	11	set	set	NOUN
admet-995	200	12	of	of	ADP
admet-995	200	13	compounds	compound	NOUN
admet-995	200	14	using	use	VERB
admet-995	200	15	the	the	DET
admet-995	200	16	model	model	NOUN
admet-995	200	17	described	describe	VERB
admet-995	200	18	by	by	ADP
admet-995	200	19	equation	equation	NOUN
admet-995	200	20	3	3	NUM
admet-995	200	21	.	.	PUNCT
admet-995	201	1	the	the	DET
admet-995	201	2	residuals	residual	NOUN
admet-995	201	3	show	show	VERB
admet-995	201	4	the	the	DET
admet-995	201	5	difference	difference	NOUN
admet-995	201	6	between	between	ADP
admet-995	201	7	the	the	DET
admet-995	201	8	measured	measure	VERB
admet-995	201	9	and	and	CCONJ
admet-995	201	10	predicted	predict	VERB
admet-995	201	11	values	value	NOUN
admet-995	201	12	.	.	PUNCT
admet-995	202	1	drug	drug	NOUN
admet-995	202	2	model	model	NOUN
admet-995	202	3	derived	derive	VERB
admet-995	202	4	with	with	ADP
admet-995	202	5	measured	measure	VERB
admet-995	202	6	properties	property	NOUN
admet-995	202	7	(	(	PUNCT
admet-995	202	8	log	log	VERB
admet-995	202	9	k	k	PROPN
admet-995	202	10	agp	agp	PROPN
admet-995	202	11	and	and	CCONJ
admet-995	202	12	log	log	VERB
admet-995	202	13	k	k	PROPN
admet-995	202	14	iam	iam	PROPN
admet-995	202	15	)	)	PUNCT
admet-995	202	16	model	model	NOUN
admet-995	202	17	derived	derive	VERB
admet-995	202	18	with	with	ADP
admet-995	202	19	calculated	calculate	VERB
admet-995	202	20	properties	property	NOUN
admet-995	202	21	(	(	PUNCT
admet-995	202	22	log	log	VERB
admet-995	202	23	p	p	NOUN
admet-995	202	24	and	and	CCONJ
admet-995	202	25	f-	f-	CCONJ
admet-995	202	26	)	)	PUNCT
admet-995	202	27	experimental	experimental	ADJ
admet-995	202	28	pic50	pic50	NOUN
admet-995	202	29	predicted	predict	VERB
admet-995	202	30	pic50	pic50	ADJ
admet-995	202	31	residual	residual	ADJ
admet-995	202	32	predicted	predict	VERB
admet-995	202	33	pic50	pic50	NOUN
admet-995	202	34	residual	residual	ADJ
admet-995	202	35	alfuzosin	alfuzosin	NOUN
admet-995	202	36	4.28	4.28	NUM
admet-995	202	37	4.74	4.74	NUM
admet-995	202	38	0.46	0.46	NUM
admet-995	202	39	3.85	3.85	NUM
admet-995	202	40	0.42	0.42	NUM
admet-995	202	41	desloratadine	desloratadine	NOUN
admet-995	202	42	5.75	5.75	NUM
admet-995	202	43	5.78	5.78	NUM
admet-995	202	44	0.04	0.04	NUM
admet-995	202	45	5.51	5.51	NUM
admet-995	202	46	0.24	0.24	NUM
admet-995	202	47	diphenhydramine	diphenhydramine	NOUN
admet-995	202	48	4.94	4.94	NUM
admet-995	202	49	5.02	5.02	NUM
admet-995	202	50	0.08	0.08	NUM
admet-995	202	51	5.23	5.23	NUM
admet-995	202	52	0.29	0.29	NUM
admet-995	202	53	dofetilide	dofetilide	NOUN
admet-995	202	54	5.72	5.72	NUM
admet-995	202	55	4.96	4.96	NUM
admet-995	202	56	0.76	0.76	NUM
admet-995	202	57	4.85	4.85	NUM
admet-995	202	58	0.87	0.87	NUM
admet-995	202	59	flecainide	flecainide	NOUN
admet-995	202	60	5.25	5.25	NUM
admet-995	202	61	4.75	4.75	NUM
admet-995	202	62	0.50	0.50	NUM
admet-995	202	63	5.38	5.38	NUM
admet-995	202	64	0.13	0.13	NUM
admet-995	202	65	fluoxetine	fluoxetine	NOUN
admet-995	202	66	5.73	5.73	NUM
admet-995	202	67	5.74	5.74	NUM
admet-995	202	68	0.01	0.01	NUM
admet-995	202	69	5.65	5.65	NUM
admet-995	202	70	0.08	0.08	NUM
admet-995	202	71	indomethacin	indomethacin	VERB
admet-995	202	72	3.72	3.72	NUM
admet-995	202	73	4.55	4.55	NUM
admet-995	202	74	0.83	0.83	NUM
admet-995	202	75	4.08	4.08	NUM
admet-995	202	76	0.36	0.36	NUM
admet-995	202	77	irbesartan	irbesartan	NOUN
admet-995	202	78	4.71	4.71	NUM
admet-995	202	79	5.28	5.28	NUM
admet-995	202	80	0.57	0.57	NUM
admet-995	202	81	5.73	5.73	NUM
admet-995	202	82	1.02	1.02	NUM
admet-995	202	83	lamotrigine	lamotrigine	NOUN
admet-995	202	84	3.55	3.55	NUM
admet-995	202	85	3.97	3.97	NUM
admet-995	202	86	0.42	0.42	NUM
admet-995	202	87	4.94	4.94	NUM
admet-995	202	88	1.39	1.39	NUM
admet-995	202	89	metoprolol	metoprolol	NOUN
admet-995	202	90	3.84	3.84	NUM
admet-995	202	91	4.25	4.25	NUM
admet-995	202	92	0.41	0.41	NUM
admet-995	202	93	4.65	4.65	NUM
admet-995	202	94	0.82	0.82	NUM
admet-995	202	95	protriptyline	protriptyline	NOUN
admet-995	202	96	5.30	5.30	NUM
admet-995	202	97	5.71	5.71	NUM
admet-995	202	98	0.40	0.40	NUM
admet-995	202	99	5.81	5.81	NUM
admet-995	202	100	0.50	0.50	NUM
admet-995	202	101	sildenafil	sildenafil	NOUN
admet-995	202	102	4.61	4.61	NUM
admet-995	202	103	4.85	4.85	NUM
admet-995	202	104	0.24	0.24	NUM
admet-995	202	105	4.89	4.89	NUM
admet-995	202	106	0.28	0.28	NUM
admet-995	202	107	spironolactone	spironolactone	NOUN
admet-995	202	108	4.64	4.64	NUM
admet-995	202	109	4.96	4.96	NUM
admet-995	202	110	0.32	0.32	NUM
admet-995	202	111	4.90	4.90	NUM
admet-995	202	112	0.26	0.26	NUM
admet-995	202	113	trazodone	trazodone	NOUN
admet-995	202	114	5.30	5.30	NUM
admet-995	202	115	4.84	4.84	NUM
admet-995	202	116	0.46	0.46	NUM
admet-995	202	117	5.38	5.38	NUM
admet-995	202	118	0.08	0.08	NUM
admet-995	202	119	trimethoprim	trimethoprim	NOUN
admet-995	202	120	3.62	3.62	NUM
admet-995	202	121	3.99	3.99	NUM
admet-995	202	122	0.37	0.37	NUM
admet-995	202	123	4.43	4.43	NUM
admet-995	202	124	0.81	0.81	NUM
admet-995	202	125	ziprasidone	ziprasidone	NOUN
admet-995	202	126	6.44	6.44	NUM
admet-995	202	127	5.69	5.69	NUM
admet-995	202	128	0.75	0.75	NUM
admet-995	202	129	5.69	5.69	NUM
admet-995	202	130	0.75	0.75	NUM
admet-995	202	131	admet	admet	NOUN
admet-995	202	132	&	&	CCONJ
admet-995	202	133	dmpk	dmpk	PROPN
admet-995	202	134	9(3	9(3	NUM
admet-995	202	135	)	)	PUNCT
admet-995	202	136	(	(	PUNCT
admet-995	202	137	2021	2021	NUM
admet-995	202	138	)	)	PUNCT
admet-995	202	139	191	191	NUM
admet-995	202	140	-	-	SYM
admet-995	202	141	207	207	NUM
admet-995	202	142	prediction	prediction	NOUN
admet-995	202	143	of	of	ADP
admet-995	202	144	herg	herg	PROPN
admet-995	202	145	inhibition	inhibition	NOUN
admet-995	202	146	by	by	ADP
admet-995	202	147	biomimetic	biomimetic	ADJ
admet-995	202	148	measurements	measurement	NOUN
admet-995	202	149	doi	doi	NOUN
admet-995	202	150	:	:	PUNCT
admet-995	202	151	http://dx.doi.org/10.5599/admet.995	http://dx.doi.org/10.5599/admet.995	ADJ
admet-995	202	152	205	205	NUM
admet-995	202	153	conclusions	conclusion	NOUN
admet-995	202	154	the	the	DET
admet-995	202	155	herg	herg	PROPN
admet-995	202	156	channel	channel	NOUN
admet-995	202	157	inhibition	inhibition	NOUN
admet-995	202	158	properties	property	NOUN
admet-995	202	159	of	of	ADP
admet-995	202	160	drugs	drug	NOUN
admet-995	202	161	and	and	CCONJ
admet-995	202	162	drug	drug	NOUN
admet-995	202	163	discovery	discovery	NOUN
admet-995	202	164	compounds	compound	NOUN
admet-995	202	165	are	be	AUX
admet-995	202	166	an	an	DET
admet-995	202	167	important	important	ADJ
admet-995	202	168	attribute	attribute	NOUN
admet-995	202	169	as	as	ADP
admet-995	202	170	compounds	compound	NOUN
admet-995	202	171	with	with	ADP
admet-995	202	172	strong	strong	ADJ
admet-995	202	173	binding	binding	NOUN
admet-995	202	174	can	can	AUX
admet-995	202	175	cause	cause	VERB
admet-995	202	176	cardiotoxic	cardiotoxic	ADJ
admet-995	202	177	side	side	NOUN
admet-995	202	178	effects	effect	NOUN
admet-995	202	179	during	during	ADP
admet-995	202	180	clinical	clinical	ADJ
admet-995	202	181	trials	trial	NOUN
admet-995	202	182	.	.	PUNCT
admet-995	203	1	early	early	ADJ
admet-995	203	2	recognition	recognition	NOUN
admet-995	203	3	of	of	ADP
admet-995	203	4	a	a	DET
admet-995	203	5	compound	compound	NOUN
admet-995	203	6	’s	’s	PART
admet-995	203	7	herg	herg	PROPN
admet-995	203	8	inhibition	inhibition	NOUN
admet-995	203	9	potential	potential	NOUN
admet-995	203	10	is	be	AUX
admet-995	203	11	important	important	ADJ
admet-995	203	12	to	to	PART
admet-995	203	13	avoid	avoid	VERB
admet-995	203	14	the	the	DET
admet-995	203	15	progression	progression	NOUN
admet-995	203	16	of	of	ADP
admet-995	203	17	compounds	compound	NOUN
admet-995	203	18	that	that	PRON
admet-995	203	19	fail	fail	VERB
admet-995	203	20	later	later	ADV
admet-995	203	21	because	because	SCONJ
admet-995	203	22	of	of	ADP
admet-995	203	23	cardiotoxicity	cardiotoxicity	NOUN
admet-995	203	24	.	.	PUNCT
admet-995	204	1	it	it	PRON
admet-995	204	2	has	have	AUX
admet-995	204	3	been	be	AUX
admet-995	204	4	demonstrated	demonstrate	VERB
admet-995	204	5	that	that	SCONJ
admet-995	204	6	two	two	NUM
admet-995	204	7	biomimetic	biomimetic	ADJ
admet-995	204	8	hplc	hplc	NOUN
admet-995	204	9	property	property	NOUN
admet-995	204	10	measurements	measurement	NOUN
admet-995	204	11	can	can	AUX
admet-995	204	12	be	be	AUX
admet-995	204	13	used	use	VERB
admet-995	204	14	for	for	ADP
admet-995	204	15	screening	screen	VERB
admet-995	204	16	molecules	molecule	NOUN
admet-995	204	17	for	for	ADP
admet-995	204	18	herg	herg	PROPN
admet-995	204	19	inhibition	inhibition	NOUN
admet-995	204	20	potential	potential	NOUN
admet-995	204	21	at	at	ADP
admet-995	204	22	an	an	DET
admet-995	204	23	early	early	ADJ
admet-995	204	24	stage	stage	NOUN
admet-995	204	25	of	of	ADP
admet-995	204	26	the	the	DET
admet-995	204	27	drug	drug	NOUN
admet-995	204	28	discovery	discovery	NOUN
admet-995	204	29	process	process	NOUN
admet-995	204	30	.	.	PUNCT
admet-995	205	1	the	the	DET
admet-995	205	2	model	model	NOUN
admet-995	205	3	is	be	AUX
admet-995	205	4	based	base	VERB
admet-995	205	5	on	on	ADP
admet-995	205	6	the	the	DET
admet-995	205	7	strong	strong	ADJ
admet-995	205	8	similarity	similarity	NOUN
admet-995	205	9	between	between	ADP
admet-995	205	10	the	the	DET
admet-995	205	11	agp	agp	PROPN
admet-995	205	12	and	and	CCONJ
admet-995	205	13	herg	herg	PROPN
admet-995	205	14	channel	channel	NOUN
admet-995	205	15	structures	structure	NOUN
admet-995	205	16	.	.	PUNCT
admet-995	206	1	both	both	PRON
admet-995	206	2	attract	attract	VERB
admet-995	206	3	positively	positively	ADV
admet-995	206	4	charged	charge	VERB
admet-995	206	5	compounds	compound	NOUN
admet-995	206	6	with	with	ADP
admet-995	206	7	a	a	DET
admet-995	206	8	significant	significant	ADJ
admet-995	206	9	degree	degree	NOUN
admet-995	206	10	of	of	ADP
admet-995	206	11	lipophilicity	lipophilicity	NOUN
admet-995	206	12	.	.	PUNCT
admet-995	207	1	both	both	PRON
admet-995	207	2	exhibit	exhibit	VERB
admet-995	207	3	steric	steric	ADJ
admet-995	207	4	hindrance	hindrance	NOUN
admet-995	207	5	depending	depend	VERB
admet-995	207	6	on	on	ADP
admet-995	207	7	the	the	DET
admet-995	207	8	size	size	NOUN
admet-995	207	9	and	and	CCONJ
admet-995	207	10	shape	shape	NOUN
admet-995	207	11	of	of	ADP
admet-995	207	12	the	the	DET
admet-995	207	13	molecule	molecule	NOUN
admet-995	207	14	being	be	AUX
admet-995	207	15	investigated	investigate	VERB
admet-995	207	16	.	.	PUNCT
admet-995	208	1	the	the	DET
admet-995	208	2	membrane	membrane	NOUN
admet-995	208	3	partition	partition	NOUN
admet-995	208	4	is	be	AUX
admet-995	208	5	also	also	ADV
admet-995	208	6	an	an	DET
admet-995	208	7	important	important	ADJ
admet-995	208	8	parameter	parameter	NOUN
admet-995	208	9	as	as	SCONJ
admet-995	208	10	it	it	PRON
admet-995	208	11	reveals	reveal	VERB
admet-995	208	12	the	the	DET
admet-995	208	13	membrane	membrane	NOUN
admet-995	208	14	affinity	affinity	NOUN
admet-995	208	15	of	of	ADP
admet-995	208	16	the	the	DET
admet-995	208	17	compounds	compound	NOUN
admet-995	208	18	where	where	SCONJ
admet-995	208	19	the	the	DET
admet-995	208	20	ion	ion	NOUN
admet-995	208	21	channel	channel	NOUN
admet-995	208	22	receptor	receptor	NOUN
admet-995	208	23	is	be	AUX
admet-995	208	24	located	locate	VERB
admet-995	208	25	.	.	PUNCT
admet-995	209	1	it	it	PRON
admet-995	209	2	has	have	AUX
admet-995	209	3	also	also	ADV
admet-995	209	4	been	be	AUX
admet-995	209	5	shown	show	VERB
admet-995	209	6	that	that	SCONJ
admet-995	209	7	two	two	NUM
admet-995	209	8	-	-	PUNCT
admet-995	209	9	dimensional	dimensional	ADJ
admet-995	209	10	physicochemical	physicochemical	ADJ
admet-995	209	11	descriptors	descriptor	NOUN
admet-995	209	12	can	can	AUX
admet-995	209	13	not	not	PART
admet-995	209	14	provide	provide	VERB
admet-995	209	15	an	an	DET
admet-995	209	16	acceptable	acceptable	ADJ
admet-995	209	17	model	model	NOUN
admet-995	209	18	for	for	ADP
admet-995	209	19	estimating	estimate	VERB
admet-995	209	20	the	the	DET
admet-995	209	21	herg	herg	PROPN
admet-995	209	22	pic50	pic50	NOUN
admet-995	209	23	of	of	ADP
admet-995	209	24	molecules	molecule	NOUN
admet-995	209	25	.	.	PUNCT
admet-995	210	1	conflict	conflict	NOUN
admet-995	210	2	of	of	ADP
admet-995	210	3	interest	interest	NOUN
admet-995	210	4	:	:	PUNCT
admet-995	210	5	klara	klara	PROPN
admet-995	210	6	valko	valko	PROPN
admet-995	210	7	is	be	AUX
admet-995	210	8	the	the	DET
admet-995	210	9	founder	founder	NOUN
admet-995	210	10	of	of	ADP
admet-995	210	11	biomimetic	biomimetic	PROPN
admet-995	210	12	chromatography	chromatography	PROPN
admet-995	210	13	ltd	ltd	PROPN
admet-995	210	14	.	.	PROPN
admet-995	210	15	references	reference	NOUN
admet-995	210	16	[	[	X
admet-995	210	17	1	1	NUM
admet-995	210	18	]	]	PUNCT
admet-995	210	19	i.	i.	PROPN
admet-995	210	20	kola	kola	PROPN
admet-995	210	21	,	,	PUNCT
admet-995	210	22	j.	j.	PROPN
admet-995	210	23	landis	landis	PROPN
admet-995	210	24	.	.	PUNCT
admet-995	211	1	can	can	AUX
admet-995	211	2	the	the	DET
admet-995	211	3	pharmaceutical	pharmaceutical	NOUN
admet-995	211	4	industry	industry	NOUN
admet-995	211	5	reduce	reduce	VERB
admet-995	211	6	attrition	attrition	NOUN
admet-995	211	7	rates	rate	NOUN
admet-995	211	8	?	?	PUNCT
admet-995	212	1	,	,	PUNCT
admet-995	212	2	nat	nat	PROPN
admet-995	212	3	.	.	PUNCT
admet-995	213	1	rev	rev	PROPN
admet-995	213	2	.	.	PROPN
admet-995	213	3	drug	drug	NOUN
admet-995	213	4	discov	discov	NOUN
admet-995	213	5	.	.	PUNCT
admet-995	214	1	3	3	NUM
admet-995	214	2	(	(	PUNCT
admet-995	214	3	2004	2004	NUM
admet-995	214	4	)	)	PUNCT
admet-995	214	5	1–5	1–5	NUM
admet-995	214	6	.	.	PUNCT
admet-995	214	7	https://doi.org/10.1038/nrd1470	https://doi.org/10.1038/nrd1470	NUM
admet-995	214	8	.	.	PUNCT
admet-995	215	1	[	[	X
admet-995	215	2	2	2	NUM
admet-995	215	3	]	]	X
admet-995	215	4	m.j	m.j	PROPN
admet-995	215	5	.	.	PROPN
admet-995	215	6	waring	waring	PROPN
admet-995	215	7	,	,	PUNCT
admet-995	215	8	j.	j.	PROPN
admet-995	215	9	arrowsmith	arrowsmith	PROPN
admet-995	215	10	,	,	PUNCT
admet-995	215	11	a.r	a.r	PROPN
admet-995	215	12	.	.	PROPN
admet-995	215	13	leach	leach	NOUN
admet-995	215	14	,	,	PUNCT
admet-995	215	15	p.d	p.d	PROPN
admet-995	215	16	.	.	PROPN
admet-995	215	17	leeson	leeson	PROPN
admet-995	215	18	,	,	PUNCT
admet-995	215	19	s.	s.	PROPN
admet-995	215	20	mandrell	mandrell	PROPN
admet-995	215	21	,	,	PUNCT
admet-995	215	22	r.m	r.m	PROPN
admet-995	215	23	.	.	PROPN
admet-995	215	24	owen	owen	PROPN
admet-995	215	25	,	,	PUNCT
admet-995	215	26	g.	g.	PROPN
admet-995	215	27	pairaudeau	pairaudeau	PROPN
admet-995	215	28	,	,	PUNCT
admet-995	215	29	w.d	w.d	PROPN
admet-995	215	30	.	.	PROPN
admet-995	215	31	pennie	pennie	PROPN
admet-995	215	32	,	,	PUNCT
admet-995	215	33	s.d	s.d	PROPN
admet-995	215	34	.	.	PROPN
admet-995	215	35	pickett	pickett	PROPN
admet-995	215	36	,	,	PUNCT
admet-995	215	37	j.	j.	PROPN
admet-995	215	38	wang	wang	PROPN
admet-995	215	39	,	,	PUNCT
admet-995	215	40	o.	o.	PROPN
admet-995	215	41	wallace	wallace	PROPN
admet-995	215	42	,	,	PUNCT
admet-995	215	43	a.	a.	PROPN
admet-995	215	44	weir	weir	PROPN
admet-995	215	45	.	.	PUNCT
admet-995	216	1	an	an	DET
admet-995	216	2	analysis	analysis	NOUN
admet-995	216	3	of	of	ADP
admet-995	216	4	the	the	DET
admet-995	216	5	attrition	attrition	NOUN
admet-995	216	6	of	of	ADP
admet-995	216	7	drug	drug	NOUN
admet-995	216	8	candidates	candidate	NOUN
admet-995	216	9	from	from	ADP
admet-995	216	10	four	four	NUM
admet-995	216	11	major	major	ADJ
admet-995	216	12	pharmaceutical	pharmaceutical	ADJ
admet-995	216	13	companies	company	NOUN
admet-995	216	14	.	.	PUNCT
admet-995	217	1	nat	nat	PROPN
admet-995	217	2	.	.	PUNCT
admet-995	218	1	rev	rev	PROPN
admet-995	218	2	.	.	PROPN
admet-995	218	3	drug	drug	NOUN
admet-995	218	4	discov	discov	NOUN
admet-995	218	5	.	.	PUNCT
admet-995	219	1	14	14	NUM
admet-995	219	2	(	(	PUNCT
admet-995	219	3	2015	2015	NUM
admet-995	219	4	)	)	PUNCT
admet-995	220	1	475–486	475–486	NUM
admet-995	220	2	.	.	PUNCT
admet-995	220	3	https://doi.org/10.1038/nrd4609	https://doi.org/10.1038/nrd4609	PROPN
admet-995	220	4	.	.	PUNCT
admet-995	221	1	[	[	X
admet-995	221	2	3	3	X
admet-995	221	3	]	]	X
admet-995	221	4	f.	f.	PROPN
admet-995	221	5	peter	peter	PROPN
admet-995	221	6	guengerich	guengerich	PROPN
admet-995	221	7	.	.	PUNCT
admet-995	222	1	mechanisms	mechanism	NOUN
admet-995	222	2	of	of	ADP
admet-995	222	3	drug	drug	NOUN
admet-995	222	4	toxicity	toxicity	NOUN
admet-995	222	5	and	and	CCONJ
admet-995	222	6	relevance	relevance	NOUN
admet-995	222	7	to	to	ADP
admet-995	222	8	pharmaceutical	pharmaceutical	NOUN
admet-995	222	9	development	development	NOUN
admet-995	222	10	.	.	PUNCT
admet-995	223	1	drug	drug	NOUN
admet-995	223	2	metab	metab	PROPN
admet-995	223	3	.	.	PUNCT
admet-995	224	1	pharmacokinet	pharmacokinet	NOUN
admet-995	224	2	.	.	PUNCT
admet-995	225	1	26	26	NUM
admet-995	225	2	(	(	PUNCT
admet-995	225	3	2011	2011	NUM
admet-995	225	4	)	)	PUNCT
admet-995	225	5	3–14	3–14	PROPN
admet-995	225	6	.	.	PUNCT
admet-995	226	1	https://doi.org/10.2133/dmpk.dmpk-10-rv-062	https://doi.org/10.2133/dmpk.dmpk-10-rv-062	NOUN
admet-995	226	2	.	.	PUNCT
admet-995	227	1	[	[	X
admet-995	227	2	4	4	NUM
admet-995	227	3	]	]	PUNCT
admet-995	227	4	a.	a.	NOUN
admet-995	227	5	casartelli	casartelli	PROPN
admet-995	227	6	,	,	PUNCT
admet-995	227	7	a.	a.	PROPN
admet-995	227	8	lanzoni	lanzoni	PROPN
admet-995	227	9	,	,	PUNCT
admet-995	227	10	r.	r.	PROPN
admet-995	227	11	comelli	comelli	PROPN
admet-995	227	12	,	,	PUNCT
admet-995	227	13	f.	f.	PROPN
admet-995	227	14	crivellente	crivellente	PROPN
admet-995	227	15	,	,	PUNCT
admet-995	227	16	r.	r.	PROPN
admet-995	227	17	defazio	defazio	PROPN
admet-995	227	18	,	,	PUNCT
admet-995	227	19	r.	r.	PROPN
admet-995	227	20	dorigatti	dorigatti	PROPN
admet-995	227	21	,	,	PUNCT
admet-995	227	22	n.	n.	PROPN
admet-995	227	23	fasdelli	fasdelli	PROPN
admet-995	227	24	,	,	PUNCT
admet-995	227	25	i.	i.	PROPN
admet-995	227	26	faustinelli	faustinelli	PROPN
admet-995	227	27	,	,	PUNCT
admet-995	227	28	s.	s.	PROPN
admet-995	227	29	pagliarusco	pagliarusco	PROPN
admet-995	227	30	,	,	PUNCT
admet-995	227	31	m.	m.	NOUN
admet-995	227	32	tontodonati	tontodonati	PROPN
admet-995	227	33	,	,	PUNCT
admet-995	227	34	p.	p.	NOUN
admet-995	227	35	cristofori	cristofori	PROPN
admet-995	227	36	.	.	PUNCT
admet-995	228	1	a	a	DET
admet-995	228	2	novel	novel	NOUN
admet-995	228	3	and	and	CCONJ
admet-995	228	4	integrated	integrated	ADJ
admet-995	228	5	approach	approach	NOUN
admet-995	228	6	for	for	ADP
admet-995	228	7	the	the	DET
admet-995	228	8	identification	identification	NOUN
admet-995	228	9	and	and	CCONJ
admet-995	228	10	characterization	characterization	NOUN
admet-995	228	11	of	of	ADP
admet-995	228	12	drug	drug	NOUN
admet-995	228	13	-	-	PUNCT
admet-995	228	14	induced	induce	VERB
admet-995	228	15	cardiac	cardiac	ADJ
admet-995	228	16	toxicity	toxicity	NOUN
admet-995	228	17	in	in	ADP
admet-995	228	18	the	the	DET
admet-995	228	19	dog	dog	NOUN
admet-995	228	20	.	.	PUNCT
admet-995	229	1	toxicol	toxicol	PROPN
admet-995	229	2	.	.	PUNCT
admet-995	229	3	pathol	pathol	PROPN
admet-995	229	4	.	.	PUNCT
admet-995	230	1	39	39	NUM
admet-995	230	2	(	(	PUNCT
admet-995	230	3	2011	2011	NUM
admet-995	230	4	)	)	PUNCT
admet-995	230	5	361–371	361–371	NUM
admet-995	230	6	.	.	PUNCT
admet-995	231	1	https://doi.org/10.1177/0192623310390704	https://doi.org/10.1177/0192623310390704	X
admet-995	231	2	.	.	PUNCT
admet-995	232	1	[	[	X
admet-995	232	2	5	5	NUM
admet-995	232	3	]	]	X
admet-995	232	4	n.	n.	PROPN
admet-995	232	5	ferri	ferri	PROPN
admet-995	232	6	,	,	PUNCT
admet-995	232	7	p.	p.	PROPN
admet-995	232	8	siegl	siegl	PROPN
admet-995	232	9	,	,	PUNCT
admet-995	232	10	a.	a.	PROPN
admet-995	232	11	corsini	corsini	PROPN
admet-995	232	12	,	,	PUNCT
admet-995	232	13	j.	j.	PROPN
admet-995	232	14	herrmann	herrmann	PROPN
admet-995	232	15	,	,	PUNCT
admet-995	232	16	a.	a.	NOUN
admet-995	232	17	lerman	lerman	PROPN
admet-995	232	18	,	,	PUNCT
admet-995	232	19	r.	r.	PROPN
admet-995	232	20	benghozi	benghozi	PROPN
admet-995	232	21	.	.	PUNCT
admet-995	232	22	drug	drug	NOUN
admet-995	232	23	attrition	attrition	NOUN
admet-995	232	24	during	during	ADP
admet-995	232	25	pre	pre	ADJ
admet-995	232	26	-	-	ADJ
admet-995	232	27	clinical	clinical	ADJ
admet-995	232	28	and	and	CCONJ
admet-995	232	29	clinical	clinical	ADJ
admet-995	232	30	development	development	NOUN
admet-995	232	31	:	:	PUNCT
admet-995	232	32	understanding	understanding	NOUN
admet-995	232	33	and	and	CCONJ
admet-995	232	34	managing	manage	VERB
admet-995	232	35	drug	drug	NOUN
admet-995	232	36	-	-	PUNCT
admet-995	232	37	induced	induce	VERB
admet-995	232	38	cardiotoxicity	cardiotoxicity	NOUN
admet-995	232	39	.	.	PUNCT
admet-995	233	1	pharmacol	pharmacol	PROPN
admet-995	233	2	.	.	PUNCT
admet-995	234	1	ther	ther	PROPN
admet-995	234	2	.	.	PUNCT
admet-995	235	1	138	138	NUM
admet-995	235	2	(	(	PUNCT
admet-995	235	3	2013	2013	NUM
admet-995	235	4	)	)	PUNCT
admet-995	236	1	470–484	470–484	NUM
admet-995	236	2	.	.	PUNCT
admet-995	237	1	https://doi.org/10.1016/j.pharmthera.2013.03.005	https://doi.org/10.1016/j.pharmthera.2013.03.005	NUM
admet-995	237	2	.	.	PUNCT
admet-995	238	1	[	[	X
admet-995	238	2	6	6	NUM
admet-995	238	3	]	]	X
admet-995	238	4	p.j	p.j	PROPN
admet-995	238	5	.	.	PUNCT
admet-995	239	1	o’brien	o’brien	PROPN
admet-995	239	2	.	.	PUNCT
admet-995	240	1	high	high	ADJ
admet-995	240	2	-	-	PUNCT
admet-995	240	3	content	content	NOUN
admet-995	240	4	analysis	analysis	NOUN
admet-995	240	5	in	in	ADP
admet-995	240	6	toxicology	toxicology	NOUN
admet-995	240	7	:	:	PUNCT
admet-995	240	8	screening	screen	VERB
admet-995	240	9	substances	substance	NOUN
admet-995	240	10	for	for	ADP
admet-995	240	11	human	human	ADJ
admet-995	240	12	toxicity	toxicity	NOUN
admet-995	240	13	potential	potential	NOUN
admet-995	240	14	,	,	PUNCT
admet-995	240	15	elucidating	elucidate	VERB
admet-995	240	16	subcellular	subcellular	ADJ
admet-995	240	17	mechanisms	mechanism	NOUN
admet-995	240	18	and	and	CCONJ
admet-995	240	19	in	in	ADP
admet-995	240	20	vivo	vivo	ADJ
admet-995	240	21	use	use	NOUN
admet-995	240	22	as	as	ADP
admet-995	240	23	translational	translational	ADJ
admet-995	240	24	safety	safety	NOUN
admet-995	240	25	biomarkers	biomarker	NOUN
admet-995	240	26	.	.	PUNCT
admet-995	241	1	basic	basic	ADJ
admet-995	241	2	clin	clin	PROPN
admet-995	241	3	.	.	PUNCT
admet-995	242	1	pharmacol	pharmacol	PROPN
admet-995	242	2	.	.	PUNCT
admet-995	243	1	toxicol	toxicol	PROPN
admet-995	243	2	.	.	PUNCT
admet-995	244	1	115	115	NUM
admet-995	245	1	(	(	PUNCT
admet-995	245	2	2014	2014	NUM
admet-995	245	3	)	)	PUNCT
admet-995	245	4	4–17	4–17	NOUN
admet-995	245	5	.	.	PUNCT
admet-995	246	1	https://doi.org/10.1111/bcpt.12227	https://doi.org/10.1111/bcpt.12227	X
admet-995	246	2	.	.	PUNCT
admet-995	247	1	[	[	X
admet-995	247	2	7	7	NUM
admet-995	247	3	]	]	X
admet-995	247	4	b.j	b.j	PROPN
admet-995	247	5	.	.	PROPN
admet-995	247	6	ridder	ridder	PROPN
admet-995	247	7	,	,	PUNCT
admet-995	247	8	d.j	d.j	PROPN
admet-995	247	9	.	.	PROPN
admet-995	247	10	leishman	leishman	PROPN
admet-995	247	11	,	,	PUNCT
admet-995	247	12	m.	m.	NOUN
admet-995	247	13	bridgland	bridgland	PROPN
admet-995	247	14	-	-	PUNCT
admet-995	247	15	taylor	taylor	PROPN
admet-995	247	16	,	,	PUNCT
admet-995	247	17	et	et	PROPN
admet-995	247	18	al	al	PROPN
admet-995	247	19	.	.	PUNCT
admet-995	248	1	a	a	DET
admet-995	248	2	systematic	systematic	ADJ
admet-995	248	3	strategy	strategy	NOUN
admet-995	248	4	for	for	ADP
admet-995	248	5	estimating	estimate	VERB
admet-995	248	6	herg	herg	PROPN
admet-995	248	7	block	block	NOUN
admet-995	248	8	potency	potency	NOUN
admet-995	248	9	and	and	CCONJ
admet-995	248	10	its	its	PRON
admet-995	248	11	implications	implication	NOUN
admet-995	248	12	in	in	ADP
admet-995	248	13	a	a	DET
admet-995	248	14	new	new	ADJ
admet-995	248	15	cardiac	cardiac	ADJ
admet-995	248	16	safety	safety	NOUN
admet-995	248	17	paradigm	paradigm	NOUN
admet-995	248	18	.	.	PUNCT
admet-995	249	1	toxicol	toxicol	PROPN
admet-995	249	2	.	.	PUNCT
admet-995	250	1	appl	appl	PROPN
admet-995	250	2	.	.	PUNCT
admet-995	251	1	pharmacol	pharmacol	PROPN
admet-995	251	2	.	.	PROPN
admet-995	252	1	394	394	NUM
admet-995	252	2	(	(	PUNCT
admet-995	252	3	2020	2020	NUM
admet-995	252	4	)	)	PUNCT
admet-995	252	5	114961	114961	NUM
admet-995	252	6	.	.	PUNCT
admet-995	253	1	https://doi.org/10.1016/j.taap.2020.114961	https://doi.org/10.1016/j.taap.2020.114961	NOUN
admet-995	253	2	.	.	PUNCT
admet-995	254	1	[	[	X
admet-995	254	2	8	8	NUM
admet-995	254	3	]	]	X
admet-995	254	4	c.	c.	PROPN
admet-995	254	5	kramer	kramer	PROPN
admet-995	254	6	,	,	PUNCT
admet-995	254	7	b.	b.	PROPN
admet-995	254	8	beck	beck	PROPN
admet-995	254	9	,	,	PUNCT
admet-995	254	10	j.m	j.m	PROPN
admet-995	254	11	.	.	PROPN
admet-995	254	12	kriegl	kriegl	PROPN
admet-995	254	13	,	,	PUNCT
admet-995	254	14	t.	t.	NOUN
admet-995	254	15	clark	clark	PROPN
admet-995	254	16	.	.	PUNCT
admet-995	255	1	a	a	DET
admet-995	255	2	composite	composite	ADJ
admet-995	255	3	model	model	NOUN
admet-995	255	4	for	for	ADP
admet-995	255	5	herg	herg	PROPN
admet-995	255	6	blockade	blockade	NOUN
admet-995	255	7	,	,	PUNCT
admet-995	255	8	chemmedchem	chemmedchem	PROPN
admet-995	255	9	.	.	PROPN
admet-995	255	10	3	3	NUM
admet-995	255	11	(	(	PUNCT
admet-995	255	12	2008	2008	NUM
admet-995	255	13	)	)	PUNCT
admet-995	255	14	254–265	254–265	NUM
admet-995	255	15	.	.	PUNCT
admet-995	256	1	https://doi.org/10.1002/cmdc.200700221	https://doi.org/10.1002/cmdc.200700221	NOUN
admet-995	256	2	.	.	PUNCT
admet-995	257	1	[	[	X
admet-995	257	2	9	9	NUM
admet-995	257	3	]	]	X
admet-995	257	4	a.o	a.o	PROPN
admet-995	257	5	.	.	PROPN
admet-995	257	6	aptula	aptula	PROPN
admet-995	257	7	,	,	PUNCT
admet-995	257	8	m.t.d	m.t.d	PROPN
admet-995	257	9	.	.	PUNCT
admet-995	257	10	cronin	cronin	PROPN
admet-995	257	11	.	.	PUNCT
admet-995	258	1	prediction	prediction	NOUN
admet-995	258	2	of	of	ADP
admet-995	258	3	herg	herg	PROPN
admet-995	258	4	k+	k+	NOUN
admet-995	258	5	blocking	block	VERB
admet-995	258	6	potency	potency	NOUN
admet-995	258	7	:	:	PUNCT
admet-995	258	8	application	application	NOUN
admet-995	258	9	of	of	ADP
admet-995	258	10	structural	structural	ADJ
admet-995	258	11	knowledge	knowledge	NOUN
admet-995	258	12	,	,	PUNCT
admet-995	258	13	sar	sar	PROPN
admet-995	258	14	qsar	qsar	PROPN
admet-995	258	15	environ	environ	PROPN
admet-995	258	16	.	.	PUNCT
admet-995	259	1	res	re	NOUN
admet-995	259	2	.	.	PROPN
admet-995	259	3	15	15	NUM
admet-995	259	4	(	(	PUNCT
admet-995	259	5	2004	2004	NUM
admet-995	259	6	)	)	PUNCT
admet-995	260	1	399–411	399–411	NUM
admet-995	260	2	.	.	PUNCT
admet-995	261	1	https://doi.org/10.1080/10629360412331297353	https://doi.org/10.1080/10629360412331297353	X
admet-995	261	2	.	.	PUNCT
admet-995	262	1	[	[	X
admet-995	262	2	10	10	NUM
admet-995	262	3	]	]	X
admet-995	262	4	e.	e.	PROPN
admet-995	262	5	raschi	raschi	PROPN
admet-995	262	6	,	,	PUNCT
admet-995	262	7	v.	v.	ADP
admet-995	262	8	vasina	vasina	NOUN
admet-995	262	9	,	,	PUNCT
admet-995	262	10	e.	e.	PROPN
admet-995	262	11	poluzzi	poluzzi	PROPN
admet-995	262	12	,	,	PUNCT
admet-995	262	13	f.	f.	PROPN
admet-995	262	14	de	de	PROPN
admet-995	262	15	ponti	ponti	PROPN
admet-995	262	16	.	.	PUNCT
admet-995	263	1	the	the	DET
admet-995	263	2	herg	herg	PROPN
admet-995	263	3	k+	k+	PROPN
admet-995	263	4	channel	channel	PROPN
admet-995	263	5	:	:	PUNCT
admet-995	263	6	target	target	NOUN
admet-995	263	7	and	and	CCONJ
admet-995	263	8	antitarget	antitarget	NOUN
admet-995	263	9	strategies	strategy	NOUN
admet-995	263	10	in	in	ADP
admet-995	263	11	drug	drug	NOUN
admet-995	263	12	development	development	NOUN
admet-995	263	13	.	.	PUNCT
admet-995	264	1	pharmacol	pharmacol	PROPN
admet-995	264	2	.	.	PUNCT
admet-995	265	1	res	re	NOUN
admet-995	265	2	.	.	PROPN
admet-995	266	1	57	57	NUM
admet-995	266	2	(	(	PUNCT
admet-995	266	3	2008	2008	NUM
admet-995	266	4	)	)	PUNCT
admet-995	267	1	181–195	181–195	NUM
admet-995	267	2	.	.	PUNCT
admet-995	268	1	https://doi.org/10.1016/j.phrs.2008.01.009	https://doi.org/10.1016/j.phrs.2008.01.009	X
admet-995	268	2	.	.	PUNCT
admet-995	269	1	http://dx.doi.org/10.5599/admet.0000	http://dx.doi.org/10.5599/admet.0000	VERB
admet-995	269	2	https://doi.org/10.1038/nrd1470	https://doi.org/10.1038/nrd1470	PROPN
admet-995	269	3	https://doi.org/10.1038/nrd4609	https://doi.org/10.1038/nrd4609	PROPN
admet-995	269	4	https://doi.org/10.1038/nrd4609	https://doi.org/10.1038/nrd4609	PROPN
admet-995	269	5	https://doi.org/10.2133/dmpk.dmpk-10-rv-062	https://doi.org/10.2133/dmpk.dmpk-10-rv-062	PROPN
admet-995	269	6	https://doi.org/10.1177/0192623310390704	https://doi.org/10.1177/0192623310390704	NOUN
admet-995	269	7	https://doi.org/10.1016/j.pharmthera.2013.03.005	https://doi.org/10.1016/j.pharmthera.2013.03.005	NUM
admet-995	269	8	https://doi.org/10.1111/bcpt.12227	https://doi.org/10.1111/bcpt.12227	PART
admet-995	270	1	https://doi.org/10.1016/j.taap.2020.114961	https://doi.org/10.1016/j.taap.2020.114961	ADJ
admet-995	270	2	https://doi.org/10.1002/cmdc.200700221	https://doi.org/10.1002/cmdc.200700221	ADJ
admet-995	270	3	https://doi.org/10.1016/j.phrs.2008.01.009	https://doi.org/10.1016/j.phrs.2008.01.009	X
admet-995	270	4	stergiopoulos	stergiopoulo	NOUN
admet-995	270	5	,	,	PUNCT
admet-995	270	6	tsopelas	tsopela	NOUN
admet-995	270	7	and	and	CCONJ
admet-995	270	8	valko	valko	PROPN
admet-995	270	9	admet	admet	PROPN
admet-995	270	10	&	&	CCONJ
admet-995	270	11	dmpk	dmpk	PROPN
admet-995	270	12	9(3	9(3	NUM
admet-995	270	13	)	)	PUNCT
admet-995	270	14	(	(	PUNCT
admet-995	270	15	2021	2021	NUM
admet-995	270	16	)	)	PUNCT
admet-995	270	17	191	191	NUM
admet-995	270	18	-	-	SYM
admet-995	270	19	207	207	NUM
admet-995	270	20	206	206	NUM
admet-995	270	21	[	[	X
admet-995	270	22	11	11	NUM
admet-995	270	23	]	]	X
admet-995	270	24	s.	s.	PROPN
admet-995	270	25	munawar	munawar	PROPN
admet-995	270	26	,	,	PUNCT
admet-995	270	27	m.j	m.j	PROPN
admet-995	270	28	.	.	PROPN
admet-995	270	29	windley	windley	PROPN
admet-995	270	30	,	,	PUNCT
admet-995	270	31	e.g.	e.g.	ADV
admet-995	270	32	tse	tse	PROPN
admet-995	270	33	,	,	PUNCT
admet-995	270	34	m.h	m.h	PROPN
admet-995	270	35	.	.	PROPN
admet-995	270	36	todd	todd	PROPN
admet-995	270	37	,	,	PUNCT
admet-995	270	38	a.p	a.p	PROPN
admet-995	270	39	.	.	PROPN
admet-995	270	40	hill	hill	PROPN
admet-995	270	41	,	,	PUNCT
admet-995	270	42	j.i	j.i	PROPN
admet-995	270	43	.	.	PROPN
admet-995	270	44	vandenberg	vandenberg	PROPN
admet-995	270	45	,	,	PUNCT
admet-995	270	46	i.	i.	PROPN
admet-995	270	47	jabeen	jabeen	PROPN
admet-995	270	48	.	.	PUNCT
admet-995	271	1	experimentally	experimentally	ADV
admet-995	271	2	validated	validate	VERB
admet-995	271	3	pharmacoinformatics	pharmacoinformatic	NOUN
admet-995	271	4	approach	approach	NOUN
admet-995	271	5	to	to	PART
admet-995	271	6	predict	predict	VERB
admet-995	271	7	herg	herg	PROPN
admet-995	271	8	inhibition	inhibition	NOUN
admet-995	271	9	potential	potential	NOUN
admet-995	271	10	of	of	ADP
admet-995	271	11	new	new	ADJ
admet-995	271	12	chemical	chemical	NOUN
admet-995	271	13	entities	entity	NOUN
admet-995	271	14	.	.	PUNCT
admet-995	272	1	front	front	ADJ
admet-995	272	2	.	.	PUNCT
admet-995	273	1	pharmacol	pharmacol	NOUN
admet-995	273	2	.	.	PUNCT
admet-995	274	1	9	9	NUM
admet-995	274	2	(	(	PUNCT
admet-995	274	3	2018	2018	NUM
admet-995	274	4	)	)	PUNCT
admet-995	274	5	1–20	1–20	NOUN
admet-995	274	6	.	.	PUNCT
admet-995	275	1	https://doi.org/10.3389/fphar.2018.01035	https://doi.org/10.3389/fphar.2018.01035	PROPN
admet-995	275	2	.	.	PUNCT
admet-995	276	1	[	[	X
admet-995	276	2	12	12	NUM
admet-995	276	3	]	]	X
admet-995	276	4	j.w	j.w	PROPN
admet-995	276	5	.	.	PROPN
admet-995	276	6	warmke	warmke	PROPN
admet-995	276	7	,	,	PUNCT
admet-995	276	8	b.	b.	PROPN
admet-995	276	9	ganetzky	ganetzky	PROPN
admet-995	276	10	.	.	PUNCT
admet-995	277	1	a	a	DET
admet-995	277	2	family	family	NOUN
admet-995	277	3	of	of	ADP
admet-995	277	4	potassium	potassium	NOUN
admet-995	277	5	channel	channel	NOUN
admet-995	277	6	genes	gene	NOUN
admet-995	277	7	related	relate	VERB
admet-995	277	8	to	to	ADP
admet-995	277	9	eag	eag	PROPN
admet-995	277	10	in	in	ADP
admet-995	277	11	drosophila	drosophila	PROPN
admet-995	277	12	and	and	CCONJ
admet-995	277	13	mammals	mammal	NOUN
admet-995	277	14	,	,	PUNCT
admet-995	277	15	proc	proc	NOUN
admet-995	277	16	.	.	PUNCT
admet-995	278	1	natl	natl	PROPN
admet-995	278	2	.	.	PUNCT
admet-995	279	1	acad	acad	PROPN
admet-995	279	2	.	.	PUNCT
admet-995	280	1	sci	sci	PROPN
admet-995	280	2	.	.	PUNCT
admet-995	280	3	u.	u.	PROPN
admet-995	280	4	s.	s.	PROPN
admet-995	280	5	a.	a.	PROPN
admet-995	280	6	91	91	NUM
admet-995	280	7	(	(	PUNCT
admet-995	280	8	1994	1994	NUM
admet-995	280	9	)	)	PUNCT
admet-995	280	10	3438–3442	3438–3442	NUM
admet-995	280	11	.	.	PUNCT
admet-995	281	1	https://doi.org/10.1073/pnas.91.8.3438	https://doi.org/10.1073/pnas.91.8.3438	NOUN
admet-995	281	2	.	.	PUNCT
admet-995	282	1	[	[	X
admet-995	282	2	13	13	NUM
admet-995	282	3	]	]	PUNCT
admet-995	282	4	l.	l.	PROPN
admet-995	282	5	du	du	PROPN
admet-995	282	6	,	,	PUNCT
admet-995	282	7	m.	m.	PROPN
admet-995	282	8	li	li	PROPN
admet-995	282	9	,	,	PUNCT
admet-995	282	10	q.	q.	VERB
admet-995	282	11	you	you	PRON
admet-995	282	12	.	.	PUNCT
admet-995	283	1	the	the	DET
admet-995	283	2	interactions	interaction	NOUN
admet-995	283	3	between	between	ADP
admet-995	283	4	herg	herg	PROPN
admet-995	283	5	potassium	potassium	NOUN
admet-995	283	6	channel	channel	NOUN
admet-995	283	7	and	and	CCONJ
admet-995	283	8	blockers	blocker	NOUN
admet-995	283	9	.	.	PUNCT
admet-995	284	1	curr	curr	PROPN
admet-995	284	2	.	.	PUNCT
admet-995	284	3	top	top	PROPN
admet-995	284	4	.	.	PUNCT
admet-995	285	1	med	med	PROPN
admet-995	285	2	.	.	PROPN
admet-995	285	3	chem	chem	PROPN
admet-995	285	4	.	.	PUNCT
admet-995	286	1	9	9	NUM
admet-995	286	2	(	(	PUNCT
admet-995	286	3	2012	2012	NUM
admet-995	286	4	)	)	PUNCT
admet-995	287	1	330–338	330–338	NUM
admet-995	287	2	.	.	PUNCT
admet-995	288	1	https://doi.org/10.2174/156802609788317829	https://doi.org/10.2174/156802609788317829	NOUN
admet-995	288	2	.	.	PUNCT
admet-995	289	1	[	[	X
admet-995	289	2	14	14	NUM
admet-995	289	3	]	]	X
admet-995	289	4	j.t	j.t	PROPN
admet-995	289	5	.	.	PROPN
admet-995	289	6	milnes	milne	NOUN
admet-995	289	7	,	,	PUNCT
admet-995	289	8	o.	o.	PROPN
admet-995	289	9	crociani	crociani	PROPN
admet-995	289	10	,	,	PUNCT
admet-995	289	11	a.	a.	NOUN
admet-995	289	12	arcangeli	arcangeli	PROPN
admet-995	289	13	,	,	PUNCT
admet-995	289	14	j.c	j.c	PROPN
admet-995	289	15	.	.	PROPN
admet-995	289	16	hancox	hancox	PROPN
admet-995	289	17	,	,	PUNCT
admet-995	289	18	h.j	h.j	PROPN
admet-995	289	19	.	.	PROPN
admet-995	289	20	witchel	witchel	PROPN
admet-995	289	21	.	.	PUNCT
admet-995	290	1	blockade	blockade	NOUN
admet-995	290	2	of	of	ADP
admet-995	290	3	herg	herg	PROPN
admet-995	290	4	potassium	potassium	NOUN
admet-995	290	5	currents	current	NOUN
admet-995	290	6	by	by	ADP
admet-995	290	7	fluvoxamine	fluvoxamine	PROPN
admet-995	290	8	:	:	PUNCT
admet-995	290	9	incomplete	incomplete	ADJ
admet-995	290	10	attenuation	attenuation	NOUN
admet-995	290	11	by	by	ADP
admet-995	290	12	s6	s6	PROPN
admet-995	290	13	mutations	mutation	NOUN
admet-995	290	14	at	at	ADP
admet-995	290	15	f656	f656	PROPN
admet-995	290	16	or	or	CCONJ
admet-995	290	17	y652	y652	PROPN
admet-995	290	18	.	.	PUNCT
admet-995	291	1	br	br	PROPN
admet-995	291	2	.	.	PUNCT
admet-995	292	1	j.	j.	PROPN
admet-995	292	2	pharmacol	pharmacol	PROPN
admet-995	292	3	.	.	PROPN
admet-995	293	1	139	139	NUM
admet-995	293	2	(	(	PUNCT
admet-995	293	3	2003	2003	NUM
admet-995	293	4	)	)	PUNCT
admet-995	294	1	887–898	887–898	NUM
admet-995	294	2	.	.	PUNCT
admet-995	295	1	https://doi.org/10.1038/sj.bjp.0705335	https://doi.org/10.1038/sj.bjp.0705335	PROPN
admet-995	295	2	.	.	PUNCT
admet-995	296	1	[	[	X
admet-995	296	2	15	15	NUM
admet-995	296	3	]	]	X
admet-995	296	4	a.m.	a.m.	PROPN
admet-995	296	5	aronov	aronov	PROPN
admet-995	296	6	.	.	PROPN
admet-995	296	7	predictive	predictive	NOUN
admet-995	296	8	in	in	ADP
admet-995	296	9	silico	silico	NOUN
admet-995	296	10	modeling	modeling	NOUN
admet-995	296	11	for	for	ADP
admet-995	296	12	herg	herg	PROPN
admet-995	296	13	channel	channel	NOUN
admet-995	296	14	blockers	blocker	NOUN
admet-995	296	15	.	.	PUNCT
admet-995	297	1	drug	drug	NOUN
admet-995	297	2	discov	discov	NOUN
admet-995	297	3	.	.	PUNCT
admet-995	298	1	today	today	NOUN
admet-995	298	2	10	10	NUM
admet-995	298	3	(	(	PUNCT
admet-995	298	4	2005	2005	NUM
admet-995	298	5	)	)	PUNCT
admet-995	299	1	149–155	149–155	NUM
admet-995	299	2	.	.	PUNCT
admet-995	299	3	https://doi.org/10.1016/s1359-6446(04)03278-7	https://doi.org/10.1016/s1359-6446(04)03278-7	PROPN
admet-995	299	4	.	.	PUNCT
admet-995	300	1	[	[	X
admet-995	300	2	16	16	NUM
admet-995	300	3	]	]	X
admet-995	300	4	w.s	w.s	PROPN
admet-995	300	5	.	.	PROPN
admet-995	300	6	redfern	redfern	PROPN
admet-995	300	7	,	,	PUNCT
admet-995	300	8	l.	l.	PROPN
admet-995	300	9	carlsson	carlsson	PROPN
admet-995	300	10	,	,	PUNCT
admet-995	300	11	a.s	a.s	PROPN
admet-995	300	12	.	.	PROPN
admet-995	300	13	davis	davis	PROPN
admet-995	300	14	,	,	PUNCT
admet-995	300	15	w.g	w.g	PROPN
admet-995	300	16	.	.	PROPN
admet-995	300	17	lynch	lynch	PROPN
admet-995	300	18	,	,	PUNCT
admet-995	300	19	i.	i.	PROPN
admet-995	300	20	mackenzie	mackenzie	PROPN
admet-995	300	21	,	,	PUNCT
admet-995	300	22	s.	s.	PROPN
admet-995	300	23	palethorpe	palethorpe	PROPN
admet-995	300	24	,	,	PUNCT
admet-995	300	25	p.k.s	p.k.	NOUN
admet-995	300	26	.	.	PUNCT
admet-995	300	27	siegl	siegl	PROPN
admet-995	300	28	,	,	PUNCT
admet-995	300	29	i.	i.	PROPN
admet-995	300	30	strang	strang	PROPN
admet-995	300	31	,	,	PUNCT
admet-995	300	32	a.t	a.t	PROPN
admet-995	300	33	.	.	PROPN
admet-995	300	34	sullivan	sullivan	PROPN
admet-995	300	35	,	,	PUNCT
admet-995	300	36	r.	r.	PROPN
admet-995	300	37	wallis	wallis	PROPN
admet-995	300	38	,	,	PUNCT
admet-995	300	39	a.j	a.j	PROPN
admet-995	300	40	.	.	PROPN
admet-995	300	41	camm	camm	PROPN
admet-995	300	42	,	,	PUNCT
admet-995	300	43	t.g	t.g	PROPN
admet-995	300	44	.	.	PROPN
admet-995	300	45	hammond	hammond	PROPN
admet-995	300	46	.	.	PUNCT
admet-995	301	1	relationships	relationship	NOUN
admet-995	301	2	between	between	ADP
admet-995	301	3	preclinical	preclinical	ADJ
admet-995	301	4	cardiac	cardiac	ADJ
admet-995	301	5	electrophysiology	electrophysiology	NOUN
admet-995	301	6	,	,	PUNCT
admet-995	301	7	clinical	clinical	ADJ
admet-995	301	8	qt	qt	NOUN
admet-995	301	9	interval	interval	NOUN
admet-995	301	10	prolongation	prolongation	NOUN
admet-995	301	11	and	and	CCONJ
admet-995	301	12	torsade	torsade	NOUN
admet-995	301	13	de	de	ADP
admet-995	301	14	pointes	pointe	NOUN
admet-995	301	15	for	for	ADP
admet-995	301	16	a	a	DET
admet-995	301	17	broad	broad	ADJ
admet-995	301	18	range	range	NOUN
admet-995	301	19	of	of	ADP
admet-995	301	20	drugs	drug	NOUN
admet-995	301	21	:	:	PUNCT
admet-995	301	22	evidence	evidence	NOUN
admet-995	301	23	for	for	ADP
admet-995	301	24	a	a	DET
admet-995	301	25	provisional	provisional	ADJ
admet-995	301	26	safety	safety	NOUN
admet-995	301	27	margin	margin	NOUN
admet-995	301	28	in	in	ADP
admet-995	301	29	drug	drug	NOUN
admet-995	301	30	development	development	NOUN
admet-995	301	31	.	.	PUNCT
admet-995	302	1	cardiovasc	cardiovasc	PROPN
admet-995	302	2	.	.	PUNCT
admet-995	303	1	res	re	NOUN
admet-995	303	2	.	.	PUNCT
admet-995	304	1	58	58	NUM
admet-995	304	2	(	(	PUNCT
admet-995	304	3	2003	2003	NUM
admet-995	304	4	)	)	PUNCT
admet-995	304	5	32	32	NUM
admet-995	304	6	–	–	PUNCT
admet-995	304	7	45	45	NUM
admet-995	304	8	.	.	PUNCT
admet-995	305	1	https://doi.org/10.1016/s0008-6363(02)00846-5	https://doi.org/10.1016/s0008-6363(02)00846-5	PROPN
admet-995	305	2	.	.	PUNCT
admet-995	306	1	[	[	X
admet-995	306	2	17	17	NUM
admet-995	306	3	]	]	X
admet-995	306	4	r.	r.	PROPN
admet-995	306	5	netzer	netzer	PROPN
admet-995	306	6	,	,	PUNCT
admet-995	306	7	a.	a.	NOUN
admet-995	306	8	ebneth	ebneth	PROPN
admet-995	306	9	,	,	PUNCT
admet-995	306	10	u.	u.	PROPN
admet-995	306	11	bischoff	bischoff	PROPN
admet-995	306	12	,	,	PUNCT
admet-995	306	13	o.	o.	NOUN
admet-995	306	14	pongs	pong	NOUN
admet-995	306	15	.	.	PUNCT
admet-995	307	1	screening	screen	VERB
admet-995	307	2	lead	lead	NOUN
admet-995	307	3	compounds	compound	NOUN
admet-995	307	4	for	for	ADP
admet-995	307	5	qt	qt	NOUN
admet-995	307	6	interval	interval	NOUN
admet-995	307	7	prolongation	prolongation	NOUN
admet-995	307	8	.	.	PUNCT
admet-995	308	1	drug	drug	NOUN
admet-995	308	2	discov	discov	NOUN
admet-995	308	3	.	.	PUNCT
admet-995	309	1	today	today	NOUN
admet-995	309	2	6	6	NUM
admet-995	309	3	(	(	PUNCT
admet-995	309	4	2001	2001	NUM
admet-995	309	5	)	)	PUNCT
admet-995	309	6	78–84	78–84	NOUN
admet-995	309	7	.	.	PUNCT
admet-995	310	1	https://doi.org/10.1016/s1359-6446(00)01602-0	https://doi.org/10.1016/s1359-6446(00)01602-0	ADV
admet-995	310	2	.	.	PUNCT
admet-995	311	1	[	[	X
admet-995	311	2	18	18	NUM
admet-995	311	3	]	]	PUNCT
admet-995	311	4	c.	c.	NOUN
admet-995	311	5	wood	wood	PROPN
admet-995	311	6	,	,	PUNCT
admet-995	311	7	c.	c.	PROPN
admet-995	311	8	williams	williams	PROPN
admet-995	311	9	,	,	PUNCT
admet-995	311	10	g.j	g.j	PROPN
admet-995	311	11	.	.	PROPN
admet-995	311	12	waldron	waldron	PROPN
admet-995	311	13	.	.	PUNCT
admet-995	312	1	patch	patch	VERB
admet-995	312	2	clamping	clamp	VERB
admet-995	312	3	by	by	ADP
admet-995	312	4	numbers	number	NOUN
admet-995	312	5	.	.	PUNCT
admet-995	313	1	drug	drug	NOUN
admet-995	313	2	discov	discov	NOUN
admet-995	313	3	.	.	PUNCT
admet-995	314	1	today	today	NOUN
admet-995	314	2	9	9	NUM
admet-995	314	3	(	(	PUNCT
admet-995	314	4	2004	2004	NUM
admet-995	314	5	)	)	PUNCT
admet-995	314	6	434	434	NUM
admet-995	314	7	–	–	PUNCT
admet-995	314	8	441	441	NUM
admet-995	314	9	.	.	PUNCT
admet-995	314	10	https://doi.org/10.1016/s1359-6446(04)03064-8	https://doi.org/10.1016/s1359-6446(04)03064-8	PROPN
admet-995	314	11	.	.	PUNCT
admet-995	315	1	[	[	X
admet-995	315	2	19	19	NUM
admet-995	315	3	]	]	X
admet-995	315	4	r.j	r.j	PROPN
admet-995	315	5	.	.	PROPN
admet-995	315	6	young	young	ADJ
admet-995	315	7	,	,	PUNCT
admet-995	315	8	d.v.s	d.v.s	NOUN
admet-995	315	9	.	.	PUNCT
admet-995	315	10	green	green	PROPN
admet-995	315	11	,	,	PUNCT
admet-995	315	12	c.n	c.n	PROPN
admet-995	315	13	.	.	PROPN
admet-995	315	14	luscombe	luscombe	PROPN
admet-995	315	15	,	,	PUNCT
admet-995	315	16	a.p	a.p	PROPN
admet-995	315	17	.	.	PROPN
admet-995	315	18	hill	hill	PROPN
admet-995	315	19	.	.	PUNCT
admet-995	316	1	getting	get	VERB
admet-995	316	2	physical	physical	ADJ
admet-995	316	3	in	in	ADP
admet-995	316	4	drug	drug	PROPN
admet-995	316	5	discovery	discovery	PROPN
admet-995	316	6	ii	ii	PROPN
admet-995	316	7	 	 	SPACE
admet-995	316	8	:	:	PUNCT
admet-995	316	9	the	the	DET
admet-995	316	10	impact	impact	NOUN
admet-995	316	11	of	of	ADP
admet-995	316	12	chromatographic	chromatographic	ADJ
admet-995	316	13	hydrophobicity	hydrophobicity	NOUN
admet-995	316	14	measurements	measurement	NOUN
admet-995	316	15	and	and	CCONJ
admet-995	316	16	aromaticity	aromaticity	NOUN
admet-995	316	17	.	.	PUNCT
admet-995	316	18	drug	drug	NOUN
admet-995	316	19	discov	discov	NOUN
admet-995	316	20	.	.	PUNCT
admet-995	317	1	today	today	NOUN
admet-995	317	2	16	16	NUM
admet-995	317	3	(	(	PUNCT
admet-995	317	4	2011	2011	NUM
admet-995	317	5	)	)	PUNCT
admet-995	317	6	822	822	NUM
admet-995	317	7	–	–	PUNCT
admet-995	317	8	830	830	NUM
admet-995	317	9	.	.	PUNCT
admet-995	318	1	https://doi.org/10.1016/j.drudis.2011.06.001	https://doi.org/10.1016/j.drudis.2011.06.001	PROPN
admet-995	318	2	.	.	PUNCT
admet-995	319	1	[	[	X
admet-995	319	2	20	20	NUM
admet-995	319	3	]	]	PUNCT
admet-995	319	4	a.	a.	NOUN
admet-995	319	5	fernández	fernández	PROPN
admet-995	319	6	-	-	PUNCT
admet-995	319	7	pumarega	pumarega	PROPN
admet-995	319	8	,	,	PUNCT
admet-995	319	9	b.	b.	PROPN
admet-995	319	10	martín	martín	PROPN
admet-995	319	11	-	-	PUNCT
admet-995	319	12	sanz	sanz	PROPN
admet-995	319	13	,	,	PUNCT
admet-995	319	14	s.	s.	PROPN
admet-995	319	15	amézqueta	amézqueta	PROPN
admet-995	319	16	,	,	PUNCT
admet-995	319	17	e.	e.	PROPN
admet-995	319	18	fuguet	fuguet	PROPN
admet-995	319	19	,	,	PUNCT
admet-995	319	20	m.	m.	NOUN
admet-995	319	21	rosés	rosés	PROPN
admet-995	319	22	.	.	PUNCT
admet-995	320	1	estimation	estimation	NOUN
admet-995	320	2	of	of	ADP
admet-995	320	3	the	the	DET
admet-995	320	4	octanol	octanol	NOUN
admet-995	320	5	-	-	PUNCT
admet-995	320	6	water	water	NOUN
admet-995	320	7	distribution	distribution	NOUN
admet-995	320	8	coefficient	coefficient	NOUN
admet-995	320	9	of	of	ADP
admet-995	320	10	basic	basic	ADJ
admet-995	320	11	compounds	compound	NOUN
admet-995	320	12	by	by	ADP
admet-995	320	13	a	a	DET
admet-995	320	14	cationic	cationic	ADJ
admet-995	320	15	microemulsion	microemulsion	NOUN
admet-995	320	16	electrokinetic	electrokinetic	ADJ
admet-995	320	17	chromatography	chromatography	NOUN
admet-995	320	18	system	system	NOUN
admet-995	320	19	.	.	PUNCT
admet-995	321	1	admet	admet	PROPN
admet-995	321	2	dmpk	dmpk	PROPN
admet-995	321	3	8	8	NUM
admet-995	321	4	(	(	PUNCT
admet-995	321	5	2020	2020	NUM
admet-995	321	6	)	)	PUNCT
admet-995	322	1	98–112	98–112	PROPN
admet-995	322	2	.	.	PUNCT
admet-995	323	1	https://doi.org/10.5599/admet.760	https://doi.org/10.5599/admet.760	X
admet-995	323	2	.	.	PUNCT
admet-995	324	1	[	[	X
admet-995	324	2	21	21	NUM
admet-995	324	3	]	]	PUNCT
admet-995	324	4	c.a.s	c.a.s	PROPN
admet-995	324	5	.	.	PROPN
admet-995	324	6	bergstrӧm	bergstrӧm	PROPN
admet-995	324	7	,	,	PUNCT
admet-995	324	8	a.	a.	NOUN
admet-995	324	9	avdeef	avdeef	PROPN
admet-995	324	10	.	.	PUNCT
admet-995	325	1	perspectives	perspective	NOUN
admet-995	325	2	in	in	ADP
admet-995	325	3	solubility	solubility	NOUN
admet-995	325	4	measurement	measurement	NOUN
admet-995	325	5	and	and	CCONJ
admet-995	325	6	interpretation	interpretation	NOUN
admet-995	325	7	.	.	PUNCT
admet-995	326	1	admet	admet	PROPN
admet-995	326	2	dmpk	dmpk	PROPN
admet-995	326	3	7	7	NUM
admet-995	326	4	(	(	PUNCT
admet-995	326	5	2019	2019	NUM
admet-995	326	6	)	)	PUNCT
admet-995	326	7	88–105	88–105	NUM
admet-995	326	8	.	.	PUNCT
admet-995	327	1	https://doi.org/10.5599/admet.686	https://doi.org/10.5599/admet.686	X
admet-995	327	2	.	.	PUNCT
admet-995	328	1	[	[	X
admet-995	328	2	22	22	NUM
admet-995	328	3	]	]	PUNCT
admet-995	328	4	k.	k.	PROPN
admet-995	328	5	valko	valko	PROPN
admet-995	328	6	,	,	PUNCT
admet-995	328	7	s.	s.	PROPN
admet-995	328	8	nunhuck	nunhuck	PROPN
admet-995	328	9	,	,	PUNCT
admet-995	328	10	c.	c.	PROPN
admet-995	328	11	bevan	bevan	PROPN
admet-995	328	12	,	,	PUNCT
admet-995	328	13	m.h	m.h	PROPN
admet-995	328	14	.	.	PROPN
admet-995	328	15	abraham	abraham	PROPN
admet-995	328	16	,	,	PUNCT
admet-995	328	17	d.p	d.p	PROPN
admet-995	328	18	.	.	PROPN
admet-995	328	19	reynolds	reynolds	PROPN
admet-995	328	20	.	.	PUNCT
admet-995	329	1	fast	fast	ADJ
admet-995	329	2	gradient	gradient	NOUN
admet-995	329	3	hplc	hplc	NOUN
admet-995	329	4	method	method	NOUN
admet-995	329	5	to	to	PART
admet-995	329	6	determine	determine	VERB
admet-995	329	7	compounds	compound	NOUN
admet-995	329	8	binding	bind	VERB
admet-995	329	9	to	to	ADP
admet-995	329	10	human	human	ADJ
admet-995	329	11	serum	serum	NOUN
admet-995	329	12	albumin	albumin	NOUN
admet-995	329	13	.	.	PUNCT
admet-995	330	1	relationships	relationship	NOUN
admet-995	330	2	with	with	ADP
admet-995	330	3	octanol	octanol	NOUN
admet-995	330	4	/	/	SYM
admet-995	330	5	water	water	NOUN
admet-995	330	6	and	and	CCONJ
admet-995	330	7	immobilized	immobilize	VERB
admet-995	330	8	artificial	artificial	ADJ
admet-995	330	9	membrane	membrane	NOUN
admet-995	330	10	lipophilicity	lipophilicity	NOUN
admet-995	330	11	.	.	PUNCT
admet-995	331	1	j.	j.	PROPN
admet-995	331	2	pharm	pharm	PROPN
admet-995	331	3	.	.	PUNCT
admet-995	332	1	sci	sci	PROPN
admet-995	332	2	.	.	PROPN
admet-995	333	1	92	92	NUM
admet-995	333	2	(	(	PUNCT
admet-995	333	3	2003	2003	NUM
admet-995	333	4	)	)	PUNCT
admet-995	333	5	2236	2236	NUM
admet-995	333	6	-	-	SYM
admet-995	333	7	48	48	NUM
admet-995	333	8	.	.	PUNCT
admet-995	334	1	https://doi.org/10.1002/jps.10494	https://doi.org/10.1002/jps.10494	NOUN
admet-995	334	2	.	.	PUNCT
admet-995	335	1	[	[	X
admet-995	335	2	23	23	NUM
admet-995	335	3	]	]	PUNCT
admet-995	335	4	k.	k.	PROPN
admet-995	335	5	valko	valko	PROPN
admet-995	335	6	,	,	PUNCT
admet-995	335	7	c.m	c.m	PROPN
admet-995	335	8	.	.	PROPN
admet-995	335	9	du	du	PROPN
admet-995	335	10	,	,	PUNCT
admet-995	335	11	c.d	c.d	PROPN
admet-995	335	12	.	.	PROPN
admet-995	335	13	bevan	bevan	PROPN
admet-995	335	14	,	,	PUNCT
admet-995	335	15	d.p	d.p	PROPN
admet-995	335	16	.	.	PROPN
admet-995	335	17	reynolds	reynolds	PROPN
admet-995	335	18	,	,	PUNCT
admet-995	335	19	m.h	m.h	PROPN
admet-995	335	20	.	.	PROPN
admet-995	335	21	abraham	abraham	PROPN
admet-995	335	22	.	.	PUNCT
admet-995	336	1	rapid	rapid	ADJ
admet-995	336	2	-	-	PUNCT
admet-995	336	3	gradient	gradient	NOUN
admet-995	336	4	hplc	hplc	NOUN
admet-995	336	5	method	method	NOUN
admet-995	336	6	for	for	ADP
admet-995	336	7	measuring	measure	VERB
admet-995	336	8	drug	drug	NOUN
admet-995	336	9	interactions	interaction	NOUN
admet-995	336	10	with	with	ADP
admet-995	336	11	immobilized	immobilized	ADJ
admet-995	336	12	artificial	artificial	ADJ
admet-995	336	13	membrane	membrane	NOUN
admet-995	336	14	:	:	PUNCT
admet-995	336	15	comparison	comparison	NOUN
admet-995	336	16	with	with	ADP
admet-995	336	17	other	other	ADJ
admet-995	336	18	lipophilicity	lipophilicity	NOUN
admet-995	336	19	measures	measure	NOUN
admet-995	336	20	.	.	PUNCT
admet-995	337	1	j.	j.	PROPN
admet-995	337	2	pharm	pharm	PROPN
admet-995	337	3	.	.	PUNCT
admet-995	338	1	sci	sci	PROPN
admet-995	338	2	.	.	PROPN
admet-995	338	3	89	89	NUM
admet-995	338	4	(	(	PUNCT
admet-995	338	5	2000	2000	NUM
admet-995	338	6	)	)	PUNCT
admet-995	338	7	1085	1085	NUM
admet-995	338	8	-	-	SYM
admet-995	338	9	96	96	NUM
admet-995	338	10	.	.	PUNCT
admet-995	339	1	https://doi.org/10.1002/15206017(200008)89:8<1085::aid-jps13>3.0.co;2-n	https://doi.org/10.1002/15206017(200008)89:8<1085::aid-jps13>3.0.co;2-n	PROPN
admet-995	339	2	.	.	PUNCT
admet-995	340	1	[	[	X
admet-995	340	2	24	24	NUM
admet-995	340	3	]	]	X
admet-995	340	4	s.	s.	PROPN
admet-995	340	5	bunally	bunally	PROPN
admet-995	340	6	,	,	PUNCT
admet-995	340	7	r.j	r.j	PROPN
admet-995	340	8	.	.	PROPN
admet-995	340	9	young	young	PROPN
admet-995	340	10	.	.	PUNCT
admet-995	341	1	the	the	DET
admet-995	341	2	role	role	NOUN
admet-995	341	3	and	and	CCONJ
admet-995	341	4	impact	impact	NOUN
admet-995	341	5	of	of	ADP
admet-995	341	6	high	high	ADJ
admet-995	341	7	throughput	throughput	NOUN
admet-995	341	8	biomimetic	biomimetic	ADJ
admet-995	341	9	measurements	measurement	NOUN
admet-995	341	10	in	in	ADP
admet-995	341	11	drug	drug	NOUN
admet-995	341	12	discovery	discovery	NOUN
admet-995	341	13	.	.	PUNCT
admet-995	342	1	admet	admet	PROPN
admet-995	342	2	dmpk	dmpk	PROPN
admet-995	342	3	6	6	NUM
admet-995	342	4	(	(	PUNCT
admet-995	342	5	2018	2018	NUM
admet-995	342	6	)	)	PUNCT
admet-995	343	1	74–84	74–84	NOUN
admet-995	343	2	.	.	PUNCT
admet-995	344	1	https://doi.org/10.5599/admet.530	https://doi.org/10.5599/admet.530	ADJ
admet-995	344	2	.	.	PUNCT
admet-995	345	1	[	[	X
admet-995	345	2	25	25	NUM
admet-995	345	3	]	]	X
admet-995	345	4	g.h	g.h	PROPN
admet-995	345	5	.	.	PUNCT
admet-995	345	6	goetz	goetz	PROPN
admet-995	345	7	,	,	PUNCT
admet-995	345	8	m.	m.	NOUN
admet-995	345	9	shalaeva	shalaeva	NOUN
admet-995	345	10	.	.	PUNCT
admet-995	346	1	leveraging	leverage	VERB
admet-995	346	2	chromatography	chromatography	NOUN
admet-995	346	3	based	base	VERB
admet-995	346	4	physicochemical	physicochemical	ADJ
admet-995	346	5	properties	property	NOUN
admet-995	346	6	for	for	ADP
admet-995	346	7	efficient	efficient	ADJ
admet-995	346	8	drug	drug	NOUN
admet-995	346	9	design	design	NOUN
admet-995	346	10	.	.	PUNCT
admet-995	347	1	admet	admet	PROPN
admet-995	347	2	dmpk	dmpk	PROPN
admet-995	347	3	6	6	NUM
admet-995	347	4	(	(	PUNCT
admet-995	347	5	2018	2018	NUM
admet-995	347	6	)	)	PUNCT
admet-995	347	7	71	71	NUM
admet-995	347	8	-	-	SYM
admet-995	347	9	73	73	NUM
admet-995	347	10	.	.	PUNCT
admet-995	348	1	https://doi.org/10.5599/admet.529	https://doi.org/10.5599/admet.529	PROPN
admet-995	348	2	.	.	PUNCT
admet-995	349	1	[	[	X
admet-995	349	2	26	26	NUM
admet-995	349	3	]	]	X
admet-995	349	4	f.	f.	PROPN
admet-995	349	5	hollosy	hollosy	PROPN
admet-995	349	6	,	,	PUNCT
admet-995	349	7	k.	k.	PROPN
admet-995	349	8	valko	valko	PROPN
admet-995	349	9	,	,	PUNCT
admet-995	349	10	a.	a.	PROPN
admet-995	349	11	hersey	hersey	PROPN
admet-995	349	12	,	,	PUNCT
admet-995	349	13	s.	s.	PROPN
admet-995	349	14	nunhuck	nunhuck	PROPN
admet-995	349	15	,	,	PUNCT
admet-995	349	16	g.	g.	PROPN
admet-995	349	17	keri	keri	PROPN
admet-995	349	18	,	,	PUNCT
admet-995	349	19	c.	c.	PROPN
admet-995	349	20	bevan	bevan	PROPN
admet-995	349	21	.	.	PUNCT
admet-995	350	1	estimation	estimation	NOUN
admet-995	350	2	of	of	ADP
admet-995	350	3	volume	volume	NOUN
admet-995	350	4	of	of	ADP
admet-995	350	5	distribution	distribution	NOUN
admet-995	350	6	in	in	ADP
admet-995	350	7	humans	human	NOUN
admet-995	350	8	from	from	ADP
admet-995	350	9	hplc	hplc	NOUN
admet-995	350	10	measurements	measurement	NOUN
admet-995	350	11	of	of	ADP
admet-995	350	12	human	human	ADJ
admet-995	350	13	serum	serum	NOUN
admet-995	350	14	albumin	albumin	NOUN
admet-995	350	15	binding	bind	VERB
admet-995	350	16	and	and	CCONJ
admet-995	350	17	immobilized	immobilize	VERB
admet-995	350	18	artificial	artificial	ADJ
admet-995	350	19	membrane	membrane	NOUN
admet-995	350	20	partitioning	partitioning	NOUN
admet-995	350	21	.	.	PUNCT
admet-995	351	1	j.	j.	PROPN
admet-995	351	2	med	med	PROPN
admet-995	351	3	.	.	PROPN
admet-995	351	4	chem	chem	PROPN
admet-995	351	5	.	.	PUNCT
admet-995	352	1	49	49	NUM
admet-995	352	2	(	(	PUNCT
admet-995	352	3	2006	2006	NUM
admet-995	352	4	)	)	PUNCT
admet-995	352	5	6958–6971	6958–6971	NUM
admet-995	352	6	.	.	PUNCT
admet-995	353	1	https://doi.org/10.1021/jm050957i	https://doi.org/10.1021/jm050957i	PROPN
admet-995	353	2	.	.	PUNCT
admet-995	354	1	[	[	X
admet-995	354	2	27	27	NUM
admet-995	354	3	]	]	PUNCT
admet-995	354	4	k.	k.	PROPN
admet-995	354	5	valko	valko	PROPN
admet-995	354	6	,	,	PUNCT
admet-995	354	7	e.	e.	PROPN
admet-995	354	8	chiarparin	chiarparin	PROPN
admet-995	354	9	,	,	PUNCT
admet-995	354	10	s.	s.	PROPN
admet-995	354	11	nunhuck	nunhuck	PROPN
admet-995	354	12	,	,	PUNCT
admet-995	354	13	d.	d.	PROPN
admet-995	354	14	montanari	montanari	PROPN
admet-995	354	15	.	.	PUNCT
admet-995	355	1	in	in	ADP
admet-995	355	2	vitro	vitro	X
admet-995	355	3	measurement	measurement	NOUN
admet-995	355	4	of	of	ADP
admet-995	355	5	drug	drug	NOUN
admet-995	355	6	efficiency	efficiency	NOUN
admet-995	355	7	index	index	NOUN
admet-995	355	8	to	to	PART
admet-995	355	9	aid	aid	VERB
admet-995	355	10	early	early	ADJ
admet-995	355	11	lead	lead	ADJ
admet-995	355	12	optimization	optimization	NOUN
admet-995	355	13	.	.	PUNCT
admet-995	356	1	j.	j.	PROPN
admet-995	356	2	pharm	pharm	PROPN
admet-995	356	3	.	.	PUNCT
admet-995	357	1	sci	sci	PROPN
admet-995	357	2	.	.	PROPN
admet-995	358	1	101	101	NUM
admet-995	358	2	(	(	PUNCT
admet-995	358	3	2012	2012	NUM
admet-995	358	4	)	)	PUNCT
admet-995	358	5	4155–69	4155–69	X
admet-995	358	6	.	.	PUNCT
admet-995	359	1	https://doi.org/10.1002/jps.23305	https://doi.org/10.1002/jps.23305	NOUN
admet-995	359	2	.	.	PUNCT
admet-995	360	1	[	[	X
admet-995	360	2	28	28	NUM
admet-995	360	3	]	]	X
admet-995	360	4	s.	s.	PROPN
admet-995	360	5	scheler	scheler	PROPN
admet-995	360	6	,	,	PUNCT
admet-995	360	7	a.	a.	PROPN
admet-995	360	8	fahr	fahr	PROPN
admet-995	360	9	,	,	PUNCT
admet-995	361	1	x.	x.	PROPN
admet-995	361	2	liu	liu	PROPN
admet-995	361	3	.	.	PUNCT
admet-995	362	1	linear	linear	ADJ
admet-995	362	2	combination	combination	NOUN
admet-995	362	3	methods	method	NOUN
admet-995	362	4	for	for	ADP
admet-995	362	5	prediction	prediction	NOUN
admet-995	362	6	of	of	ADP
admet-995	362	7	drug	drug	NOUN
admet-995	362	8	skin	skin	NOUN
admet-995	362	9	permeation	permeation	NOUN
admet-995	362	10	.	.	PUNCT
admet-995	363	1	admet	admet	PROPN
admet-995	363	2	dmpk	dmpk	PROPN
admet-995	363	3	2	2	NUM
admet-995	363	4	(	(	PUNCT
admet-995	363	5	2015	2015	NUM
admet-995	363	6	)	)	PUNCT
admet-995	363	7	199–220	199–220	NUM
admet-995	363	8	.	.	PUNCT
admet-995	364	1	https://doi.org/10.5599/admet.2.4.147	https://doi.org/10.5599/admet.2.4.147	PROPN
admet-995	364	2	.	.	PUNCT
admet-995	365	1	https://doi.org/10.3389/fphar.2018.01035	https://doi.org/10.3389/fphar.2018.01035	PROPN
admet-995	365	2	https://doi.org/10.2174/156802609788317829	https://doi.org/10.2174/156802609788317829	ADV
admet-995	365	3	https://doi.org/10.1038/sj.bjp.0705335	https://doi.org/10.1038/sj.bjp.0705335	NOUN
admet-995	365	4	https://doi.org/10.1016/s1359-6446(04)03278-7	https://doi.org/10.1016/s1359-6446(04)03278-7	VERB
admet-995	365	5	https://doi.org/10.1016/s0008-6363(02)00846-5	https://doi.org/10.1016/s0008-6363(02)00846-5	PROPN
admet-995	365	6	https://doi.org/10.1016/s1359-6446(00)01602-0	https://doi.org/10.1016/s1359-6446(00)01602-0	PROPN
admet-995	365	7	https://doi.org/10.1016/s1359-6446(04)03064-8	https://doi.org/10.1016/s1359-6446(04)03064-8	PROPN
admet-995	365	8	https://doi.org/10.1016/j.drudis.2011.06.001	https://doi.org/10.1016/j.drudis.2011.06.001	PROPN
admet-995	365	9	https://doi.org/10.5599/admet.760	https://doi.org/10.5599/admet.760	PROPN
admet-995	365	10	https://doi.org/10.5599/admet.686	https://doi.org/10.5599/admet.686	X
admet-995	366	1	https://doi.org/10.1002/jps.10494	https://doi.org/10.1002/jps.10494	PROPN
admet-995	366	2	https://doi.org/10.1002/jps.10494	https://doi.org/10.1002/jps.10494	PROPN
admet-995	366	3	https://doi.org/10.1002/1520-6017(200008)89:8%3c1085::aid-jps13%3e3.0.co;2-n	https://doi.org/10.1002/1520-6017(200008)89:8%3c1085::aid-jps13%3e3.0.co;2-n	NOUN
admet-995	366	4	https://doi.org/10.1002/1520-6017(200008)89:8%3c1085::aid-jps13%3e3.0.co;2-n	https://doi.org/10.1002/1520-6017(200008)89:8%3c1085::aid-jps13%3e3.0.co;2-n	NOUN
admet-995	366	5	https://doi.org/10.5599/admet.530	https://doi.org/10.5599/admet.530	NOUN
admet-995	366	6	https://doi.org/10.5599/admet.529	https://doi.org/10.5599/admet.529	ADP
admet-995	366	7	https://doi.org/10.1021/jm050957i	https://doi.org/10.1021/jm050957i	PROPN
admet-995	366	8	https://doi.org/10.1002/jps.23305	https://doi.org/10.1002/jps.23305	PROPN
admet-995	366	9	https://doi.org/10.5599/admet.2.4.147	https://doi.org/10.5599/admet.2.4.147	PROPN
admet-995	366	10	admet	admet	PROPN
admet-995	366	11	&	&	CCONJ
admet-995	366	12	dmpk	dmpk	PROPN
admet-995	366	13	9(3	9(3	NUM
admet-995	366	14	)	)	PUNCT
admet-995	366	15	(	(	PUNCT
admet-995	366	16	2021	2021	NUM
admet-995	366	17	)	)	PUNCT
admet-995	366	18	191	191	NUM
admet-995	366	19	-	-	SYM
admet-995	366	20	207	207	NUM
admet-995	366	21	prediction	prediction	NOUN
admet-995	366	22	of	of	ADP
admet-995	366	23	herg	herg	PROPN
admet-995	366	24	inhibition	inhibition	NOUN
admet-995	366	25	by	by	ADP
admet-995	366	26	biomimetic	biomimetic	ADJ
admet-995	366	27	measurements	measurement	NOUN
admet-995	366	28	doi	doi	NOUN
admet-995	366	29	:	:	PUNCT
admet-995	366	30	http://dx.doi.org/10.5599/admet.995	http://dx.doi.org/10.5599/admet.995	PROPN
admet-995	366	31	207	207	NUM
admet-995	366	32	[	[	SYM
admet-995	366	33	29	29	NUM
admet-995	366	34	]	]	X
admet-995	366	35	c.	c.	PROPN
admet-995	366	36	stephen	stephen	PROPN
admet-995	366	37	,	,	PUNCT
admet-995	366	38	a.	a.	PROPN
admet-995	366	39	el	el	PROPN
admet-995	366	40	omri	omri	PROPN
admet-995	366	41	,	,	PUNCT
admet-995	366	42	l.	l.	PROPN
admet-995	366	43	ciesla	ciesla	PROPN
admet-995	366	44	,	,	PUNCT
admet-995	366	45	cellular	cellular	ADJ
admet-995	366	46	membrane	membrane	NOUN
admet-995	366	47	affinity	affinity	NOUN
admet-995	366	48	chromatography	chromatography	NOUN
admet-995	366	49	(	(	PUNCT
admet-995	366	50	cmac	cmac	PROPN
admet-995	366	51	)	)	PUNCT
admet-995	366	52	in	in	ADP
admet-995	366	53	drug	drug	NOUN
admet-995	366	54	discovery	discovery	NOUN
admet-995	366	55	from	from	ADP
admet-995	366	56	complex	complex	ADJ
admet-995	366	57	natural	natural	ADJ
admet-995	366	58	matrices	matrix	NOUN
admet-995	366	59	.	.	PUNCT
admet-995	367	1	admet	admet	PROPN
admet-995	367	2	dmpk	dmpk	PROPN
admet-995	367	3	6	6	NUM
admet-995	367	4	(	(	PUNCT
admet-995	367	5	2018	2018	NUM
admet-995	367	6	)	)	PUNCT
admet-995	367	7	200–214	200–214	NUM
admet-995	367	8	.	.	PUNCT
admet-995	368	1	https://doi.org/10.5599/admet.535	https://doi.org/10.5599/admet.535	ADJ
admet-995	368	2	.	.	PUNCT
admet-995	369	1	[	[	X
admet-995	369	2	30	30	NUM
admet-995	369	3	]	]	X
admet-995	369	4	p.c	p.c	PROPN
admet-995	369	5	.	.	PROPN
admet-995	369	6	ray	ray	PROPN
admet-995	369	7	,	,	PUNCT
admet-995	369	8	m.	m.	NOUN
admet-995	369	9	huggett	huggett	PROPN
admet-995	369	10	,	,	PUNCT
admet-995	369	11	p.a	p.a	PROPN
admet-995	369	12	.	.	PROPN
admet-995	369	13	turner	turner	PROPN
admet-995	369	14	,	,	PUNCT
admet-995	369	15	m.	m.	PROPN
admet-995	369	16	taylor	taylor	PROPN
admet-995	369	17	,	,	PUNCT
admet-995	369	18	l.a.t	l.a.t	PROPN
admet-995	369	19	.	.	PUNCT
admet-995	370	1	cleghorn	cleghorn	PROPN
admet-995	370	2	et	et	PROPN
admet-995	370	3	al	al	PROPN
admet-995	370	4	.	.	PROPN
admet-995	370	5	spirocycle	spirocycle	PROPN
admet-995	370	6	mmpl3	mmpl3	ADJ
admet-995	370	7	inhibitors	inhibitor	NOUN
admet-995	370	8	with	with	ADP
admet-995	370	9	improved	improved	ADJ
admet-995	370	10	herg	herg	NOUN
admet-995	370	11	and	and	CCONJ
admet-995	370	12	cytotoxicity	cytotoxicity	NOUN
admet-995	370	13	profiles	profile	NOUN
admet-995	370	14	as	as	ADP
admet-995	370	15	inhibitors	inhibitor	NOUN
admet-995	370	16	of	of	ADP
admet-995	370	17	mycobacterium	mycobacterium	NOUN
admet-995	370	18	tuberculosis	tuberculosis	NOUN
admet-995	370	19	growth	growth	NOUN
admet-995	370	20	.	.	PUNCT
admet-995	371	1	acs	acs	PROPN
admet-995	371	2	omega	omega	NOUN
admet-995	371	3	6	6	NUM
admet-995	371	4	(	(	PUNCT
admet-995	371	5	2021	2021	NUM
admet-995	371	6	)	)	PUNCT
admet-995	371	7	2284	2284	NUM
admet-995	371	8	-	-	SYM
admet-995	371	9	2311	2311	NUM
admet-995	371	10	.	.	PUNCT
admet-995	372	1	https://doi.org/10.1021/acsomega.0c05589	https://doi.org/10.1021/acsomega.0c05589	ADJ
admet-995	372	2	.	.	PUNCT
admet-995	373	1	[	[	X
admet-995	373	2	31	31	NUM
admet-995	373	3	]	]	X
admet-995	373	4	f.	f.	PROPN
admet-995	373	5	tsopelas	tsopelas	PROPN
admet-995	373	6	,	,	PUNCT
admet-995	373	7	c.	c.	PROPN
admet-995	373	8	stergiopoulos	stergiopoulos	PROPN
admet-995	373	9	,	,	PUNCT
admet-995	373	10	a.	a.	NOUN
admet-995	373	11	tsantili	tsantili	NOUN
admet-995	373	12	-	-	PUNCT
admet-995	373	13	kakoulidou	kakoulidou	NOUN
admet-995	373	14	.	.	PROPN
admet-995	373	15	immobilized	immobilize	VERB
admet-995	373	16	artificial	artificial	ADJ
admet-995	373	17	membrane	membrane	NOUN
admet-995	373	18	chromatography	chromatography	NOUN
admet-995	373	19	:	:	PUNCT
admet-995	373	20	from	from	ADP
admet-995	373	21	medicinal	medicinal	ADJ
admet-995	373	22	chemistry	chemistry	NOUN
admet-995	373	23	to	to	ADP
admet-995	373	24	environmental	environmental	ADJ
admet-995	373	25	sciences	science	NOUN
admet-995	373	26	.	.	PUNCT
admet-995	374	1	admet	admet	PROPN
admet-995	374	2	dmpk	dmpk	PROPN
admet-995	374	3	6	6	NUM
admet-995	374	4	(	(	PUNCT
admet-995	374	5	2018	2018	NUM
admet-995	374	6	)	)	PUNCT
admet-995	374	7	225	225	NUM
admet-995	374	8	–	–	PUNCT
admet-995	374	9	241	241	NUM
admet-995	374	10	.	.	PUNCT
admet-995	375	1	https://doi.org/10.5599/admet.553	https://doi.org/10.5599/admet.553	NOUN
admet-995	375	2	.	.	PUNCT
admet-995	376	1	[	[	X
admet-995	376	2	32	32	NUM
admet-995	376	3	]	]	SYM
admet-995	376	4	c.m	c.m	PROPN
admet-995	376	5	.	.	PROPN
admet-995	376	6	du	du	PROPN
admet-995	376	7	,	,	PUNCT
admet-995	376	8	k.	k.	PROPN
admet-995	376	9	valko	valko	PROPN
admet-995	376	10	,	,	PUNCT
admet-995	376	11	c.	c.	PROPN
admet-995	376	12	bevan	bevan	PROPN
admet-995	376	13	,	,	PUNCT
admet-995	376	14	d.	d.	PROPN
admet-995	376	15	reynolds	reynolds	PROPN
admet-995	376	16	,	,	PUNCT
admet-995	376	17	m.h	m.h	PROPN
admet-995	376	18	.	.	PROPN
admet-995	376	19	abraham	abraham	PROPN
admet-995	376	20	.	.	PUNCT
admet-995	377	1	rapid	rapid	ADJ
admet-995	377	2	gradient	gradient	NOUN
admet-995	377	3	rp	rp	NOUN
admet-995	377	4	-	-	PUNCT
admet-995	377	5	hplc	hplc	NOUN
admet-995	377	6	method	method	NOUN
admet-995	377	7	for	for	ADP
admet-995	377	8	lipophilicity	lipophilicity	NOUN
admet-995	377	9	determination	determination	NOUN
admet-995	377	10	:	:	PUNCT
admet-995	377	11	a	a	DET
admet-995	377	12	solvation	solvation	NOUN
admet-995	377	13	equation	equation	NOUN
admet-995	377	14	based	base	VERB
admet-995	377	15	comparison	comparison	NOUN
admet-995	377	16	with	with	ADP
admet-995	377	17	isocratic	isocratic	ADJ
admet-995	377	18	methods	method	NOUN
admet-995	377	19	.	.	PUNCT
admet-995	378	1	anal	anal	ADJ
admet-995	378	2	.	.	PUNCT
admet-995	378	3	chem	chem	PROPN
admet-995	378	4	.	.	PUNCT
admet-995	379	1	70	70	NUM
admet-995	379	2	(	(	PUNCT
admet-995	379	3	1998	1998	NUM
admet-995	379	4	)	)	PUNCT
admet-995	379	5	4228	4228	NUM
admet-995	379	6	-	-	SYM
admet-995	379	7	4234	4234	NUM
admet-995	379	8	.	.	PUNCT
admet-995	380	1	https://doi.org/10.1021/ac980435	https://doi.org/10.1021/ac980435	VERB
admet-995	380	2	t.	t.	X
admet-995	380	3	[	[	X
admet-995	380	4	33	33	NUM
admet-995	380	5	]	]	PUNCT
admet-995	380	6	k.	k.	PROPN
admet-995	380	7	valko	valko	PROPN
admet-995	380	8	,	,	PUNCT
admet-995	380	9	c.m	c.m	PROPN
admet-995	380	10	.	.	PROPN
admet-995	380	11	du	du	PROPN
admet-995	380	12	,	,	PUNCT
admet-995	380	13	c.	c.	PROPN
admet-995	380	14	bevan	bevan	PROPN
admet-995	380	15	,	,	PUNCT
admet-995	381	1	d.p	d.p	PROPN
admet-995	381	2	.	.	PROPN
admet-995	381	3	reynolds	reynolds	PROPN
admet-995	381	4	,	,	PUNCT
admet-995	381	5	m.h	m.h	PROPN
admet-995	381	6	.	.	PROPN
admet-995	381	7	abraham	abraham	PROPN
admet-995	381	8	,	,	PUNCT
admet-995	381	9	rapid	rapid	ADJ
admet-995	381	10	method	method	NOUN
admet-995	381	11	for	for	ADP
admet-995	381	12	the	the	DET
admet-995	381	13	estimation	estimation	NOUN
admet-995	381	14	of	of	ADP
admet-995	381	15	octanol	octanol	NOUN
admet-995	381	16	/	/	SYM
admet-995	381	17	water	water	NOUN
admet-995	381	18	partition	partition	NOUN
admet-995	381	19	coefficient	coefficient	NOUN
admet-995	381	20	(	(	PUNCT
admet-995	381	21	log	log	PROPN
admet-995	381	22	poct	poct	PROPN
admet-995	381	23	)	)	PUNCT
admet-995	381	24	from	from	ADP
admet-995	381	25	gradient	gradient	ADJ
admet-995	381	26	rp	rp	NOUN
admet-995	381	27	-	-	PUNCT
admet-995	381	28	hplc	hplc	NOUN
admet-995	381	29	retention	retention	NOUN
admet-995	381	30	and	and	CCONJ
admet-995	381	31	a	a	DET
admet-995	381	32	hydrogen	hydrogen	NOUN
admet-995	381	33	bond	bond	NOUN
admet-995	381	34	acidity	acidity	NOUN
admet-995	381	35	term	term	NOUN
admet-995	381	36	(	(	PUNCT
admet-995	381	37	∑α2	∑α2	ADP
admet-995	381	38	h	h	NOUN
admet-995	381	39	)	)	PUNCT
admet-995	381	40	.	.	PUNCT
admet-995	382	1	curr	curr	AUX
admet-995	382	2	.	.	PUNCT
admet-995	382	3	med	med	PROPN
admet-995	382	4	.	.	PROPN
admet-995	382	5	chem	chem	PROPN
admet-995	382	6	.	.	PUNCT
admet-995	383	1	8	8	NUM
admet-995	383	2	(	(	PUNCT
admet-995	383	3	2001	2001	NUM
admet-995	383	4	)	)	PUNCT
admet-995	383	5	1137–1146	1137–1146	NUM
admet-995	383	6	.	.	PUNCT
admet-995	384	1	https://doi.org/10.2174/0929867013372643	https://doi.org/10.2174/0929867013372643	PROPN
admet-995	384	2	.	.	PUNCT
admet-995	385	1	[	[	X
admet-995	385	2	34	34	NUM
admet-995	385	3	]	]	X
admet-995	385	4	k.l	k.l	PROPN
admet-995	385	5	.	.	PROPN
admet-995	385	6	valko	valko	PROPN
admet-995	385	7	,	,	PUNCT
admet-995	385	8	s.p	s.p	PROPN
admet-995	385	9	.	.	PROPN
admet-995	385	10	teague	teague	PROPN
admet-995	385	11	,	,	PUNCT
admet-995	385	12	c.	c.	PROPN
admet-995	385	13	pidgeon	pidgeon	PROPN
admet-995	385	14	.	.	PUNCT
admet-995	386	1	in	in	ADP
admet-995	386	2	vitro	vitro	X
admet-995	386	3	membrane	membrane	NOUN
admet-995	386	4	binding	bind	VERB
admet-995	386	5	and	and	CCONJ
admet-995	386	6	protein	protein	NOUN
admet-995	386	7	binding	bind	VERB
admet-995	386	8	(	(	PUNCT
admet-995	386	9	iam	iam	PROPN
admet-995	386	10	mb	mb	PROPN
admet-995	386	11	/	/	SYM
admet-995	386	12	pb	pb	X
admet-995	386	13	technology	technology	NOUN
admet-995	386	14	)	)	PUNCT
admet-995	386	15	to	to	PART
admet-995	386	16	estimate	estimate	VERB
admet-995	386	17	in	in	ADP
admet-995	386	18	vivo	vivo	ADJ
admet-995	386	19	distribution	distribution	NOUN
admet-995	386	20	:	:	PUNCT
admet-995	386	21	applications	application	NOUN
admet-995	386	22	in	in	ADP
admet-995	386	23	early	early	ADJ
admet-995	386	24	drug	drug	NOUN
admet-995	386	25	discovery	discovery	NOUN
admet-995	386	26	.	.	PUNCT
admet-995	387	1	admet	admet	PROPN
admet-995	387	2	dmpk	dmpk	PROPN
admet-995	387	3	5	5	NUM
admet-995	387	4	(	(	PUNCT
admet-995	387	5	2017	2017	NUM
admet-995	387	6	)	)	PUNCT
admet-995	387	7	14	14	NUM
admet-995	387	8	-	-	SYM
admet-995	387	9	38	38	NUM
admet-995	387	10	.	.	PUNCT
admet-995	388	1	https://doi.org/10.5599/admet.5.1.373	https://doi.org/10.5599/admet.5.1.373	PROPN
admet-995	388	2	.	.	PUNCT
admet-995	389	1	[	[	X
admet-995	389	2	35	35	NUM
admet-995	389	3	]	]	PUNCT
admet-995	389	4	k.	k.	PROPN
admet-995	389	5	valko	valko	PROPN
admet-995	389	6	.	.	PUNCT
admet-995	390	1	handbook	handbook	NOUN
admet-995	390	2	of	of	ADP
admet-995	390	3	analytical	analytical	ADJ
admet-995	390	4	separations	separation	NOUN
admet-995	390	5	volume	volume	VERB
admet-995	390	6	8	8	NUM
admet-995	390	7	,	,	PUNCT
admet-995	390	8	separation	separation	NOUN
admet-995	390	9	methods	method	NOUN
admet-995	390	10	in	in	ADP
admet-995	390	11	drug	drug	NOUN
admet-995	390	12	synthesis	synthesis	NOUN
admet-995	390	13	and	and	CCONJ
admet-995	390	14	purification	purification	NOUN
admet-995	390	15	.	.	PUNCT
admet-995	391	1	2nd	2nd	ADJ
admet-995	391	2	ed	ed	NOUN
admet-995	391	3	.	.	PROPN
admet-995	391	4	,	,	PUNCT
admet-995	391	5	elsevier	elsevier	PROPN
admet-995	391	6	2020	2020	NUM
admet-995	391	7	p.687	p.687	NOUN
admet-995	391	8	.	.	PUNCT
admet-995	392	1	isbn	isbn	NOUN
admet-995	392	2	:	:	PUNCT
admet-995	392	3	9780444640703	9780444640703	NUM
admet-995	392	4	.	.	PUNCT
admet-995	393	1	[	[	X
admet-995	393	2	36	36	NUM
admet-995	393	3	]	]	PUNCT
admet-995	393	4	t.	t.	PROPN
admet-995	393	5	sato	sato	PROPN
admet-995	393	6	,	,	PUNCT
admet-995	393	7	h.	h.	PROPN
admet-995	393	8	yuki	yuki	PROPN
admet-995	393	9	,	,	PUNCT
admet-995	393	10	k.	k.	PROPN
admet-995	393	11	ogura	ogura	PROPN
admet-995	393	12	,	,	PUNCT
admet-995	393	13	t.	t.	PROPN
admet-995	393	14	honma	honma	PROPN
admet-995	393	15	.	.	PUNCT
admet-995	394	1	construction	construction	NOUN
admet-995	394	2	of	of	ADP
admet-995	394	3	an	an	DET
admet-995	394	4	integrated	integrate	VERB
admet-995	394	5	database	database	NOUN
admet-995	394	6	for	for	ADP
admet-995	394	7	herg	herg	PROPN
admet-995	394	8	blocking	block	VERB
admet-995	394	9	small	small	ADJ
admet-995	394	10	molecules	molecule	NOUN
admet-995	394	11	.	.	PUNCT
admet-995	395	1	plos	plos	PROPN
admet-995	395	2	one	one	NUM
admet-995	395	3	13	13	NUM
admet-995	395	4	(	(	PUNCT
admet-995	395	5	2018	2018	NUM
admet-995	395	6	)	)	PUNCT
admet-995	395	7	1–18	1–18	NUM
admet-995	395	8	.	.	PUNCT
admet-995	396	1	https://doi.org/10.1371/journal.pone.0199348	https://doi.org/10.1371/journal.pone.0199348	ADJ
admet-995	396	2	.	.	PUNCT
admet-995	397	1	[	[	X
admet-995	397	2	37	37	NUM
admet-995	397	3	]	]	X
admet-995	397	4	c.	c.	PROPN
admet-995	397	5	stergiopoulos	stergiopoulos	PROPN
admet-995	397	6	,	,	PUNCT
admet-995	397	7	d.	d.	PROPN
admet-995	397	8	makarouni	makarouni	PROPN
admet-995	397	9	,	,	PUNCT
admet-995	397	10	a.	a.	NOUN
admet-995	397	11	tsantili	tsantili	NOUN
admet-995	397	12	-	-	PUNCT
admet-995	397	13	kakoulidou	kakoulidou	NOUN
admet-995	397	14	,	,	PUNCT
admet-995	397	15	m.	m.	NOUN
admet-995	397	16	ochsenkühn	ochsenkühn	PROPN
admet-995	397	17	-	-	PUNCT
admet-995	397	18	petropoulou	petropoulou	NOUN
admet-995	397	19	,	,	PUNCT
admet-995	397	20	f.	f.	PROPN
admet-995	397	21	tsopelas	tsopelas	PROPN
admet-995	397	22	.	.	PUNCT
admet-995	397	23	immobilized	immobilize	VERB
admet-995	397	24	artificial	artificial	ADJ
admet-995	397	25	membrane	membrane	NOUN
admet-995	397	26	chromatography	chromatography	NOUN
admet-995	397	27	as	as	ADP
admet-995	397	28	a	a	DET
admet-995	397	29	tool	tool	NOUN
admet-995	397	30	for	for	ADP
admet-995	397	31	the	the	DET
admet-995	397	32	prediction	prediction	NOUN
admet-995	397	33	of	of	ADP
admet-995	397	34	ecotoxicity	ecotoxicity	NOUN
admet-995	397	35	of	of	ADP
admet-995	397	36	pesticides	pesticide	NOUN
admet-995	397	37	.	.	PUNCT
admet-995	398	1	chemosphere	chemosphere	VERB
admet-995	398	2	224	224	NUM
admet-995	398	3	(	(	PUNCT
admet-995	398	4	2019	2019	NUM
admet-995	398	5	)	)	PUNCT
admet-995	399	1	128–139	128–139	NUM
admet-995	399	2	.	.	PUNCT
admet-995	400	1	https://doi.org/10.1016/j.chemosphere.2019.02.075	https://doi.org/10.1016/j.chemosphere.2019.02.075	PROPN
admet-995	400	2	.	.	PUNCT
admet-995	401	1	[	[	X
admet-995	401	2	38	38	NUM
admet-995	401	3	]	]	PUNCT
admet-995	401	4	r.	r.	PROPN
admet-995	401	5	kaliszan	kaliszan	PROPN
admet-995	401	6	,	,	PUNCT
admet-995	401	7	a.	a.	NOUN
admet-995	401	8	nasal	nasal	PROPN
admet-995	401	9	,	,	PUNCT
admet-995	401	10	m.	m.	NOUN
admet-995	401	11	turowski	turowski	PROPN
admet-995	401	12	.	.	PUNCT
admet-995	402	1	quantitative	quantitative	ADJ
admet-995	402	2	structure	structure	NOUN
admet-995	402	3	-	-	PUNCT
admet-995	402	4	retention	retention	NOUN
admet-995	402	5	relationships	relationship	NOUN
admet-995	402	6	in	in	ADP
admet-995	402	7	the	the	DET
admet-995	402	8	examination	examination	NOUN
admet-995	402	9	of	of	ADP
admet-995	402	10	the	the	DET
admet-995	402	11	topography	topography	NOUN
admet-995	402	12	of	of	ADP
admet-995	402	13	the	the	DET
admet-995	402	14	binding	bind	VERB
admet-995	402	15	site	site	NOUN
admet-995	402	16	of	of	ADP
admet-995	402	17	antihistamine	antihistamine	PROPN
admet-995	402	18	drugs	drug	NOUN
admet-995	402	19	on	on	ADP
admet-995	402	20	α1	α1	ADJ
admet-995	402	21	-	-	PUNCT
admet-995	402	22	acid	acid	NOUN
admet-995	402	23	glycoprotein	glycoprotein	NOUN
admet-995	402	24	.	.	PUNCT
admet-995	403	1	j.	j.	PROPN
admet-995	403	2	chromatogr	chromatogr	PROPN
admet-995	403	3	.	.	PUNCT
admet-995	404	1	a	a	DET
admet-995	404	2	722	722	NUM
admet-995	404	3	(	(	PUNCT
admet-995	404	4	1996	1996	NUM
admet-995	404	5	)	)	PUNCT
admet-995	404	6	25–32	25–32	NUM
admet-995	404	7	.	.	PUNCT
admet-995	404	8	https://doi.org/10.1016/0021-9673(95)00523-4	https://doi.org/10.1016/0021-9673(95)00523-4	PROPN
admet-995	404	9	.	.	PUNCT
admet-995	405	1	[	[	X
admet-995	405	2	39	39	NUM
admet-995	405	3	]	]	PUNCT
admet-995	405	4	m.	m.	NOUN
admet-995	405	5	tristani	tristani	PROPN
admet-995	405	6	-	-	PUNCT
admet-995	405	7	firouzi	firouzi	PROPN
admet-995	405	8	,	,	PUNCT
admet-995	405	9	j.	j.	PROPN
admet-995	405	10	chen	chen	PROPN
admet-995	405	11	,	,	PUNCT
admet-995	405	12	j.s	j.s	PROPN
admet-995	405	13	.	.	PROPN
admet-995	405	14	mitcheson	mitcheson	PROPN
admet-995	405	15	,	,	PUNCT
admet-995	405	16	m.c	m.c	PROPN
admet-995	405	17	.	.	PROPN
admet-995	405	18	sanguinetti	sanguinetti	PROPN
admet-995	405	19	.	.	PUNCT
admet-995	406	1	molecular	molecular	ADJ
admet-995	406	2	biology	biology	NOUN
admet-995	406	3	of	of	ADP
admet-995	406	4	k+	k+	NOUN
admet-995	406	5	channels	channel	NOUN
admet-995	406	6	and	and	CCONJ
admet-995	406	7	their	their	PRON
admet-995	406	8	role	role	NOUN
admet-995	406	9	in	in	ADP
admet-995	406	10	cardiac	cardiac	ADJ
admet-995	406	11	arrhythmias	arrhythmia	NOUN
admet-995	406	12	.	.	PUNCT
admet-995	407	1	am	be	AUX
admet-995	407	2	.	.	PUNCT
admet-995	408	1	j.	j.	PROPN
admet-995	408	2	med	med	PROPN
admet-995	408	3	.	.	PUNCT
admet-995	409	1	110	110	NUM
admet-995	409	2	(	(	PUNCT
admet-995	409	3	2001	2001	NUM
admet-995	409	4	)	)	PUNCT
admet-995	409	5	50–59	50–59	NUM
admet-995	409	6	.	.	PUNCT
admet-995	410	1	https://doi.org/10.1016/s00029343(00)00623-9	https://doi.org/10.1016/s00029343(00)00623-9	NOUN
admet-995	410	2	.	.	PUNCT
admet-995	411	1	©	©	PROPN
admet-995	411	2	2021	2021	NUM
admet-995	411	3	by	by	ADP
admet-995	411	4	the	the	DET
admet-995	411	5	authors	author	NOUN
admet-995	411	6	;	;	PUNCT
admet-995	411	7	licensee	licensee	PROPN
admet-995	411	8	iapc	iapc	PROPN
admet-995	411	9	,	,	PUNCT
admet-995	411	10	zagreb	zagreb	PROPN
admet-995	411	11	,	,	PUNCT
admet-995	411	12	croatia	croatia	PROPN
admet-995	411	13	.	.	PUNCT
admet-995	412	1	this	this	DET
admet-995	412	2	article	article	NOUN
admet-995	412	3	is	be	AUX
admet-995	412	4	an	an	DET
admet-995	412	5	open	open	ADJ
admet-995	412	6	-	-	PUNCT
admet-995	412	7	access	access	NOUN
admet-995	412	8	article	article	NOUN
admet-995	412	9	distributed	distribute	VERB
admet-995	412	10	under	under	ADP
admet-995	412	11	the	the	DET
admet-995	412	12	terms	term	NOUN
admet-995	412	13	and	and	CCONJ
admet-995	412	14	conditions	condition	NOUN
admet-995	412	15	of	of	ADP
admet-995	412	16	the	the	DET
admet-995	412	17	creative	creative	ADJ
admet-995	412	18	commons	common	NOUN
admet-995	412	19	attribution	attribution	NOUN
admet-995	412	20	license	license	NOUN
admet-995	412	21	(	(	PUNCT
admet-995	412	22	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
admet-995	412	23	)	)	PUNCT
admet-995	412	24	http://dx.doi.org/10.5599/admet.0000	http://dx.doi.org/10.5599/admet.0000	VERB
admet-995	413	1	https://doi.org/10.5599/admet.535	https://doi.org/10.5599/admet.535	ADJ
admet-995	413	2	https://doi.org/10.5599/admet.535	https://doi.org/10.5599/admet.535	INTJ
admet-995	413	3	https://doi.org/10.1021/acsomega.0c05589	https://doi.org/10.1021/acsomega.0c05589	NOUN
admet-995	413	4	https://doi.org/10.5599/admet.553	https://doi.org/10.5599/admet.553	NOUN
admet-995	414	1	https://doi.org/10.1021/ac980435	https://doi.org/10.1021/ac980435	PROPN
admet-995	414	2	t	t	PROPN
admet-995	414	3	https://doi.org/10.2174/0929867013372643	https://doi.org/10.2174/0929867013372643	NOUN
admet-995	414	4	https://doi.org/10.2174/0929867013372643	https://doi.org/10.2174/0929867013372643	PROPN
admet-995	415	1	https://doi.org/10.5599/admet.5.1.373	https://doi.org/10.5599/admet.5.1.373	PROPN
admet-995	416	1	https://doi.org/10.1371/journal.pone.0199348	https://doi.org/10.1371/journal.pone.0199348	PROPN
admet-995	416	2	https://doi.org/10.1016/j.chemosphere.2019.02.075	https://doi.org/10.1016/j.chemosphere.2019.02.075	NOUN
admet-995	416	3	https://doi.org/10.1016/0021-9673(95)00523-4	https://doi.org/10.1016/0021-9673(95)00523-4	PROPN
admet-995	417	1	https://doi.org/10.1016/s0002-9343(00)00623-9	https://doi.org/10.1016/s0002-9343(00)00623-9	INTJ
admet-995	418	1	https://doi.org/10.1016/s0002-9343(00)00623-9	https://doi.org/10.1016/s0002-9343(00)00623-9	ADJ
admet-995	418	2	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	NOUN