id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
ijassa-493	Babushkina, Nina; Kuzina, Ekaterina	Analytical study of the antitumor viral vaccine introduction regimens based on mathematical modeling	2018	26	.pdf	application/pdf	8114	366	55	A t t N t t       =   − + − − − − −  − − +   + − − −  −  (1) where ( )V t is the number of viruses, ( )N t is the number of tumor cells without vaccine introduction, described by the following differential equation: ( ) ( ) ( ) dN t t N t dt =  , at 0 0( )N t N= (2) where  (t) is the rate of tumor cells’ proliferation, ANALYTICAL STUDY OF ANTITUMOR VIRAL VACCINE 61 ( )VN t is the number of infected tumor cells after the vaccine introduction, 1V CVt Z= + is the moment of the start of immune response against viruses, 1N CNt Z= + is the moment of the start of immune response against tumor cells, 1 is the moment of vaccine introduction, CVZ and CNZ are the time lag of immune response against the virus and infected tumor cells, 3. Calculated growth curve of the total number of tumor cells N(t) (full line) that approximates experimental data (+) based on the mathematical model of antitumor therapy (dosage 0 0,015V = on 1 = day 1); the dotted line indicates the dynamics of the number of infected tumor cells ( )VN t .	cache/ijassa-493.pdf	txt/ijassa-493.txt