id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
ajlm-1537	Hendricks, Candice L.; Naidoo, Ashen; Thejpal, Rajendra; Rapiti, Nadine; Neethling, Beverley; Goga, Yasmin; Buldeo, Suvarna	Childhood aplastic anaemia with paroxysmal nocturnal haemoglobinuria clones: A retrospective single-centre study in South Africa	2022		.htm	text/html	5554	301	53	The differences in the presentation of PNH between adults and children have been described.8 A study reported in 1991 from the United States described that haemoglobinuria was detected in 50.0% of adult PNH patients compared to 15.0% among children, and only 25.0% of adult PNH patients had bone marrow failure compared to 58.0% among children.8 Paroxysmal nocturnal haemoglobinuria clone sizes have been reported to be much lower in AA than in PNH disease,25 requiring high-sensitivity fluorescent aerolysin analysis to detect clones < 0.1%.26 Objective: This study aimed to determine the prevalence of PNH clones in paediatric patients with idiopathic AA, identify differences in clinical and laboratory features and outcomes, and determine the impact of clone size on clinical presentation.	cache/ajlm-1537.htm	txt/ajlm-1537.txt