id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
ajlm-1842	Enuma, Joseph N.; Sanni, Felix O.; Matur, Malau B.; Jean, Njab E.; Erhabor, Tosan; Egbulefu, Iheukwumere I.	Malaria an opportunistic infection in HIV/AIDS patients? – A Nigerian experience	2022		.htm	text/html	4314	224	50	HIV infection increases the probability of clinical and severe malaria, while Plasmodium falciparum infection increases HIV viral load.8,9 Additionally, dual infection has been found to contribute to the spread of both illnesses in sub-Saharan Africa, raising concerns about treating coinfected patients and the possibility of therapeutic interactions.10 Because of the significant geographic and social overlap between people infected with HIV and malaria, complex interactions at the individual and group levels are possible.11 Notably, any relationship between the two infections has the potential to have considerable public health implications due to their respective frequencies.12 HIV infection may exacerbate malaria’s burden by increasing susceptibility to infection or impairing antimalarial medications’ preventative and therapeutic efficiency, as both are immune-mediated.13 However, early 1990s investigations failed to reveal substantial interactions between malaria and HIV in coinfected children and adults who had acquired semi-immunity to malaria, probably due to research design problems and a lack of information about immunosuppression.14 In the early 2000s, it was shown that HIV infection has a clinical effect on malaria infection and disease and that this effect appears to be reliant on the dynamics of malaria transmission and the degree of HIV-associated immunosuppression.15,16 HIV-positive individuals who have not acquired immunity to malaria exhibit a significant increase in the severity of infection, in contrast to those who have naturally acquired immunity to malaria, for whom HIV infection is associated with just a mild rise in clinical disease.17 Malaria has been identified as a risk factor for concurrent HIV infection at the population level in the recent past.13 Studies have addressed the prevalence of asymptomatic malaria,18,19 association between clinical malaria and immunosuppression among HIV-positive patients.20 and effects of malaria infection on HIV-positive individuals in Nigeria,4,18,19,21,22 but information on malaria as an opportunistic infection in HIV-positive individuals is scanty. Therefore, these findings suggest that malaria parasitaemia is not an opportunistic infection among HIV-positive patients in Abuja, nor is malaria parasitaemia more common in HIV infection in Nigeria.	cache/ajlm-1842.htm	txt/ajlm-1842.txt