id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
ajlm-2613	Jimoh, Abdulrazaq A.; Adamu, Zainab A.; Rasheed, Mumini W.; Richard, Samuel K.	Expression of cyclooxygenase-2 (COX-2) in colorectal adenoma in an indigenous African population in northern Nigeria	2025		.htm	text/html	4755	258	51	The possible reason why COX-2 expression is higher in CRCs than in adenomas may be that although COX-2 expression is involved in tumour initiation, it is also a marker for advanced lesions (from dysplasia in adenomas to frank malignancy and invasiveness in carcinomas).30,31 For example, it has been shown that COX-2 expression has a positive correlation with adenoma size, dysplasia, and grade but not with the tumour location or configuration, and the expression is higher in the CRC.30,32,33,34,35 This may also explain why the expression of COX-2 in colorectal adenomas demonstrates a wide variation similar to that of the CRC, from 38% to 100%, because of adenoma size, presence of dysplasia, histological subtype, and key genetic mutation.35,36 More studies are needed for Africa to explain the possible racial disparity in COX-2 expression in adenomas, because most available COX-2 studies on colorectal adenomas and CRCs are from America and Asian countries.	cache/ajlm-2613.htm	txt/ajlm-2613.txt