id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
ajlm-2729	Kuti, Modupe A.; Adeleye, Jokotade O.; Akinyemi, Joshua O.; Ogundeji, Olajumoke A.; Omoyele, Olusola O.; Obe, Oluwadamilare A.; Adewoyin, Ademola S.; Soriyan, Oyetunji O.	Assessing the clinical implications of low-density lipoprotein cholesterol equations using Nigerian data	2025		.htm	text/html	4953	243	44	This represents a less than 15% difference for an LDL cholesterol concentration of 1.81 mmol/L. Furthermore, the recently updated set of quality requirements for acceptable performance in proficiency testing programmes released by the Clinical Laboratory Improvements Act has a target value + 20% for LDL cholesterol.12 Finally, estimates of the reference change value for LDL cholesterol, derived from biological variation data have been reported to be as high as 19%.13 The above suggests that, for the vast majority of LDL cholesterol estimates by the FF, the difference from the estimates by the newer equations may not have been clinically significant. From our data, although the level of agreement between the two equations with each other in this scenario was better than with the Friedewald equation, there were still significant differences, especially when LDL cholesterol was < 1.81 mmol/L. Very similar to our findings, Sajja et al.,25 following their review of the electronic health record data from patients with atherosclerotic cardiovascular disease, reported clinically significant discordance in a pairwise comparison of the Sampson-NIH equation and the MH equation of about 23% at LDL cholesterol values of ≥ 1.81 mmol/L.	cache/ajlm-2729.htm	txt/ajlm-2729.txt