id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
ajlm-460	Pathmanathan, Ishani; Date, Anand; Coggin, William L.; Nkengasong, John; Piatek, Amy S.; Alexander, Heather	Rolling out Xpert MTB/RIF® for tuberculosis detection in HIV-positive populations: An opportunity for systems strengthening	2017		.htm	text/html	7636	462	41	Opportunities for system strengthening along the tuberculosis diagnosis and treatment cascade Finding presumptive tuberculosis patients The WHO recommends Xpert MTB/RIF as the initial diagnostic test in individuals with suspected HIV-associated or MDR tuberculosis, which eliminates the additional clinic visit needed to perform sputum microscopy followed by Xpert MTB/RIF if negative.11,43 WHO guidelines also recommend that people living with HIV be evaluated at every clinical encounter for cough, fever, weight loss or night sweats, with positive symptom screens prompting further diagnostic evaluation; this screening algorithm has a 79% overall sensitivity (90% in clinical settings) and 50% specificity.44,45 Subsequent Xpert MTB/RIF diagnostic testing further increases case detection sensitivity and specificity; however, to test the maximum number of people living with HIV for presumptive tuberculosis, correctly-performed symptom screening is often required first. Rolling out Xpert MTB/RIF® for tuberculosis detection in HIV-positive populations: An opportunity for systems strengthening.	cache/ajlm-460.htm	txt/ajlm-460.txt