id	sid	tid	token	lemma	pos
ajlm-2384	1	1	abstract	abstract	ADJ
ajlm-2384	1	2	introduction	introduction	NOUN
ajlm-2384	1	3	ethical	ethical	ADJ
ajlm-2384	1	4	considerations	consideration	NOUN
ajlm-2384	1	5	case	case	NOUN
ajlm-2384	1	6	presentation	presentation	NOUN
ajlm-2384	1	7	management	management	NOUN
ajlm-2384	1	8	and	and	CCONJ
ajlm-2384	1	9	outcome	outcome	NOUN
ajlm-2384	1	10	discussion	discussion	NOUN
ajlm-2384	1	11	acknowledgements	acknowledgement	NOUN
ajlm-2384	1	12	references	reference	NOUN
ajlm-2384	1	13	about	about	ADP
ajlm-2384	1	14	the	the	DET
ajlm-2384	1	15	author(s	author(s	NOUN
ajlm-2384	1	16	)	)	PUNCT
ajlm-2384	1	17	herbert	herbert	PROPN
ajlm-2384	1	18	makgopa	makgopa	PROPN
ajlm-2384	1	19	department	department	PROPN
ajlm-2384	1	20	of	of	ADP
ajlm-2384	1	21	chemical	chemical	PROPN
ajlm-2384	1	22	pathology	pathology	PROPN
ajlm-2384	1	23	,	,	PUNCT
ajlm-2384	1	24	faculty	faculty	NOUN
ajlm-2384	1	25	of	of	ADP
ajlm-2384	1	26	health	health	NOUN
ajlm-2384	1	27	sciences	sciences	PROPN
ajlm-2384	1	28	,	,	PUNCT
ajlm-2384	1	29	university	university	NOUN
ajlm-2384	1	30	of	of	ADP
ajlm-2384	1	31	pretoria	pretoria	PROPN
ajlm-2384	1	32	,	,	PUNCT
ajlm-2384	1	33	pretoria	pretoria	PROPN
ajlm-2384	1	34	,	,	PUNCT
ajlm-2384	1	35	south	south	PROPN
ajlm-2384	1	36	africa	africa	PROPN
ajlm-2384	1	37	department	department	PROPN
ajlm-2384	1	38	of	of	ADP
ajlm-2384	1	39	chemical	chemical	PROPN
ajlm-2384	1	40	pathology	pathology	PROPN
ajlm-2384	1	41	,	,	PUNCT
ajlm-2384	1	42	national	national	PROPN
ajlm-2384	1	43	health	health	PROPN
ajlm-2384	1	44	laboratory	laboratory	PROPN
ajlm-2384	1	45	service	service	PROPN
ajlm-2384	1	46	,	,	PUNCT
ajlm-2384	1	47	pretoria	pretoria	PROPN
ajlm-2384	1	48	,	,	PUNCT
ajlm-2384	1	49	south	south	PROPN
ajlm-2384	1	50	africa	africa	PROPN
ajlm-2384	1	51	tanja	tanja	PROPN
ajlm-2384	1	52	kemp	kemp	PROPN
ajlm-2384	1	53	division	division	PROPN
ajlm-2384	1	54	of	of	ADP
ajlm-2384	1	55	endocrinology	endocrinology	NOUN
ajlm-2384	1	56	,	,	PUNCT
ajlm-2384	1	57	department	department	NOUN
ajlm-2384	1	58	of	of	ADP
ajlm-2384	1	59	internal	internal	ADJ
ajlm-2384	1	60	medicine	medicine	NOUN
ajlm-2384	1	61	,	,	PUNCT
ajlm-2384	1	62	faculty	faculty	NOUN
ajlm-2384	1	63	of	of	ADP
ajlm-2384	1	64	health	health	NOUN
ajlm-2384	1	65	sciences	sciences	PROPN
ajlm-2384	1	66	,	,	PUNCT
ajlm-2384	1	67	university	university	NOUN
ajlm-2384	1	68	of	of	ADP
ajlm-2384	1	69	pretoria	pretoria	PROPN
ajlm-2384	1	70	,	,	PUNCT
ajlm-2384	1	71	pretoria	pretoria	PROPN
ajlm-2384	1	72	,	,	PUNCT
ajlm-2384	1	73	south	south	PROPN
ajlm-2384	1	74	africa	africa	PROPN
ajlm-2384	1	75	surita	surita	PROPN
ajlm-2384	1	76	meldau	meldau	PROPN
ajlm-2384	1	77	division	division	NOUN
ajlm-2384	1	78	of	of	ADP
ajlm-2384	1	79	chemical	chemical	ADJ
ajlm-2384	1	80	pathology	pathology	PROPN
ajlm-2384	1	81	,	,	PUNCT
ajlm-2384	1	82	department	department	PROPN
ajlm-2384	1	83	of	of	ADP
ajlm-2384	1	84	pathology	pathology	PROPN
ajlm-2384	1	85	,	,	PUNCT
ajlm-2384	1	86	university	university	PROPN
ajlm-2384	1	87	of	of	ADP
ajlm-2384	1	88	cape	cape	PROPN
ajlm-2384	1	89	town	town	NOUN
ajlm-2384	1	90	,	,	PUNCT
ajlm-2384	1	91	cape	cape	NOUN
ajlm-2384	1	92	town	town	NOUN
ajlm-2384	1	93	,	,	PUNCT
ajlm-2384	1	94	south	south	PROPN
ajlm-2384	1	95	africa	africa	PROPN
ajlm-2384	1	96	department	department	PROPN
ajlm-2384	1	97	of	of	ADP
ajlm-2384	1	98	chemical	chemical	PROPN
ajlm-2384	1	99	pathology	pathology	PROPN
ajlm-2384	1	100	,	,	PUNCT
ajlm-2384	1	101	national	national	PROPN
ajlm-2384	1	102	health	health	PROPN
ajlm-2384	1	103	laboratory	laboratory	PROPN
ajlm-2384	1	104	service	service	PROPN
ajlm-2384	1	105	,	,	PUNCT
ajlm-2384	1	106	cape	cape	NOUN
ajlm-2384	1	107	town	town	NOUN
ajlm-2384	1	108	,	,	PUNCT
ajlm-2384	1	109	south	south	PROPN
ajlm-2384	1	110	africa	africa	PROPN
ajlm-2384	1	111	engela	engela	PROPN
ajlm-2384	1	112	m.	m.	PROPN
ajlm-2384	1	113	honey	honey	PROPN
ajlm-2384	1	114	division	division	NOUN
ajlm-2384	1	115	of	of	ADP
ajlm-2384	1	116	human	human	ADJ
ajlm-2384	1	117	genetics	genetic	NOUN
ajlm-2384	1	118	,	,	PUNCT
ajlm-2384	1	119	department	department	NOUN
ajlm-2384	1	120	of	of	ADP
ajlm-2384	1	121	biochemistry	biochemistry	NOUN
ajlm-2384	1	122	,	,	PUNCT
ajlm-2384	1	123	genetics	genetic	NOUN
ajlm-2384	1	124	and	and	CCONJ
ajlm-2384	1	125	microbiology	microbiology	NOUN
ajlm-2384	1	126	,	,	PUNCT
ajlm-2384	1	127	university	university	NOUN
ajlm-2384	1	128	of	of	ADP
ajlm-2384	1	129	pretoria	pretoria	PROPN
ajlm-2384	1	130	,	,	PUNCT
ajlm-2384	1	131	pretoria	pretoria	PROPN
ajlm-2384	1	132	,	,	PUNCT
ajlm-2384	1	133	south	south	PROPN
ajlm-2384	1	134	africa	africa	PROPN
ajlm-2384	1	135	bettina	bettina	PROPN
ajlm-2384	1	136	chale	chale	PROPN
ajlm-2384	1	137	-	-	PUNCT
ajlm-2384	1	138	matsau	matsau	PROPN
ajlm-2384	1	139	department	department	NOUN
ajlm-2384	1	140	of	of	ADP
ajlm-2384	1	141	chemical	chemical	PROPN
ajlm-2384	1	142	pathology	pathology	PROPN
ajlm-2384	1	143	,	,	PUNCT
ajlm-2384	1	144	faculty	faculty	NOUN
ajlm-2384	1	145	of	of	ADP
ajlm-2384	1	146	health	health	NOUN
ajlm-2384	1	147	sciences	sciences	PROPN
ajlm-2384	1	148	,	,	PUNCT
ajlm-2384	1	149	university	university	NOUN
ajlm-2384	1	150	of	of	ADP
ajlm-2384	1	151	pretoria	pretoria	PROPN
ajlm-2384	1	152	,	,	PUNCT
ajlm-2384	1	153	pretoria	pretoria	PROPN
ajlm-2384	1	154	,	,	PUNCT
ajlm-2384	1	155	south	south	PROPN
ajlm-2384	1	156	africa	africa	PROPN
ajlm-2384	1	157	department	department	PROPN
ajlm-2384	1	158	of	of	ADP
ajlm-2384	1	159	chemical	chemical	PROPN
ajlm-2384	1	160	pathology	pathology	PROPN
ajlm-2384	1	161	,	,	PUNCT
ajlm-2384	1	162	national	national	PROPN
ajlm-2384	1	163	health	health	PROPN
ajlm-2384	1	164	laboratory	laboratory	PROPN
ajlm-2384	1	165	service	service	PROPN
ajlm-2384	1	166	,	,	PUNCT
ajlm-2384	1	167	pretoria	pretoria	PROPN
ajlm-2384	1	168	,	,	PUNCT
ajlm-2384	1	169	south	south	PROPN
ajlm-2384	1	170	africa	africa	PROPN
ajlm-2384	1	171	citation	citation	PROPN
ajlm-2384	1	172	makgopa	makgopa	PROPN
ajlm-2384	1	173	h	h	PROPN
ajlm-2384	1	174	,	,	PUNCT
ajlm-2384	1	175	kemp	kemp	PROPN
ajlm-2384	1	176	t	t	PROPN
ajlm-2384	1	177	,	,	PUNCT
ajlm-2384	1	178	meldau	meldau	NOUN
ajlm-2384	1	179	s	s	PROPN
ajlm-2384	1	180	,	,	PUNCT
ajlm-2384	1	181	honey	honey	PROPN
ajlm-2384	1	182	em	em	PRON
ajlm-2384	1	183	,	,	PUNCT
ajlm-2384	1	184	chale	chale	PROPN
ajlm-2384	1	185	-	-	PUNCT
ajlm-2384	1	186	matsau	matsau	PROPN
ajlm-2384	1	187	b.	b.	PROPN
ajlm-2384	1	188	maternally	maternally	ADV
ajlm-2384	1	189	inherited	inherit	VERB
ajlm-2384	1	190	diabetes	diabetes	NOUN
ajlm-2384	1	191	and	and	CCONJ
ajlm-2384	1	192	deafness	deafness	NOUN
ajlm-2384	1	193	with	with	ADP
ajlm-2384	1	194	a	a	DET
ajlm-2384	1	195	variable	variable	ADJ
ajlm-2384	1	196	presentation	presentation	NOUN
ajlm-2384	1	197	across	across	ADP
ajlm-2384	1	198	three	three	NUM
ajlm-2384	1	199	generations	generation	NOUN
ajlm-2384	1	200	within	within	ADP
ajlm-2384	1	201	a	a	DET
ajlm-2384	1	202	pedigree	pedigree	ADJ
ajlm-2384	1	203	,	,	PUNCT
ajlm-2384	1	204	south	south	PROPN
ajlm-2384	1	205	africa	africa	PROPN
ajlm-2384	1	206	.	.	PUNCT
ajlm-2384	2	1	afr	afr	PROPN
ajlm-2384	2	2	j	j	PROPN
ajlm-2384	2	3	lab	lab	PROPN
ajlm-2384	2	4	med	me	VERB
ajlm-2384	2	5	.	.	PUNCT
ajlm-2384	3	1	2024;13(1	2024;13(1	NUM
ajlm-2384	3	2	)	)	PUNCT
ajlm-2384	3	3	,	,	PUNCT
ajlm-2384	4	1	a2384	a2384	PROPN
ajlm-2384	4	2	.	.	NOUN
ajlm-2384	4	3	https://doi.org/10.4102/ajlm.v13i1.2384	https://doi.org/10.4102/ajlm.v13i1.2384	AUX
ajlm-2384	4	4	case	case	NOUN
ajlm-2384	4	5	study	study	NOUN
ajlm-2384	4	6	maternally	maternally	ADV
ajlm-2384	4	7	inherited	inherit	VERB
ajlm-2384	4	8	diabetes	diabetes	NOUN
ajlm-2384	4	9	and	and	CCONJ
ajlm-2384	4	10	deafness	deafness	NOUN
ajlm-2384	4	11	with	with	ADP
ajlm-2384	4	12	a	a	DET
ajlm-2384	4	13	variable	variable	ADJ
ajlm-2384	4	14	presentation	presentation	NOUN
ajlm-2384	4	15	across	across	ADP
ajlm-2384	4	16	three	three	NUM
ajlm-2384	4	17	generations	generation	NOUN
ajlm-2384	4	18	within	within	ADP
ajlm-2384	4	19	a	a	DET
ajlm-2384	4	20	pedigree	pedigree	NOUN
ajlm-2384	4	21	,	,	PUNCT
ajlm-2384	4	22	south	south	PROPN
ajlm-2384	4	23	africa	africa	PROPN
ajlm-2384	4	24	herbert	herbert	PROPN
ajlm-2384	4	25	makgopa	makgopa	PROPN
ajlm-2384	4	26	,	,	PUNCT
ajlm-2384	4	27	tanja	tanja	PROPN
ajlm-2384	4	28	kemp	kemp	PROPN
ajlm-2384	4	29	,	,	PUNCT
ajlm-2384	4	30	surita	surita	PROPN
ajlm-2384	4	31	meldau	meldau	NOUN
ajlm-2384	4	32	,	,	PUNCT
ajlm-2384	4	33	engela	engela	PROPN
ajlm-2384	4	34	m.	m.	NOUN
ajlm-2384	4	35	honey	honey	PROPN
ajlm-2384	4	36	,	,	PUNCT
ajlm-2384	4	37	bettina	bettina	PROPN
ajlm-2384	4	38	chale	chale	PROPN
ajlm-2384	4	39	-	-	PUNCT
ajlm-2384	4	40	matsau	matsau	NOUN
ajlm-2384	4	41	received	receive	VERB
ajlm-2384	4	42	:	:	PUNCT
ajlm-2384	4	43	05	05	NUM
ajlm-2384	4	44	dec	dec	PROPN
ajlm-2384	4	45	.	.	PROPN
ajlm-2384	4	46	2023	2023	NUM
ajlm-2384	4	47	;	;	PUNCT
ajlm-2384	4	48	accepted	accept	VERB
ajlm-2384	4	49	:	:	PUNCT
ajlm-2384	4	50	20	20	NUM
ajlm-2384	4	51	mar	mar	PROPN
ajlm-2384	4	52	.	.	PROPN
ajlm-2384	4	53	2024	2024	NUM
ajlm-2384	4	54	;	;	PUNCT
ajlm-2384	4	55	published	publish	VERB
ajlm-2384	4	56	:	:	PUNCT
ajlm-2384	4	57	29	29	NUM
ajlm-2384	4	58	may	may	PROPN
ajlm-2384	4	59	2024	2024	NUM
ajlm-2384	4	60	copyright	copyright	NOUN
ajlm-2384	4	61	:	:	PUNCT
ajlm-2384	4	62	©	©	PROPN
ajlm-2384	4	63	2024	2024	NUM
ajlm-2384	4	64	.	.	PUNCT
ajlm-2384	5	1	the	the	DET
ajlm-2384	5	2	author(s	author(s	PROPN
ajlm-2384	5	3	)	)	PUNCT
ajlm-2384	5	4	.	.	PUNCT
ajlm-2384	6	1	licensee	licensee	NOUN
ajlm-2384	6	2	:	:	PUNCT
ajlm-2384	6	3	aosis	aosis	NOUN
ajlm-2384	6	4	.	.	PUNCT
ajlm-2384	7	1	this	this	PRON
ajlm-2384	7	2	is	be	AUX
ajlm-2384	7	3	an	an	DET
ajlm-2384	7	4	open	open	ADJ
ajlm-2384	7	5	access	access	NOUN
ajlm-2384	7	6	article	article	NOUN
ajlm-2384	7	7	distributed	distribute	VERB
ajlm-2384	7	8	under	under	ADP
ajlm-2384	7	9	the	the	DET
ajlm-2384	7	10	terms	term	NOUN
ajlm-2384	7	11	of	of	ADP
ajlm-2384	7	12	the	the	DET
ajlm-2384	7	13	creative	creative	ADJ
ajlm-2384	7	14	commons	common	NOUN
ajlm-2384	7	15	attribution	attribution	NOUN
ajlm-2384	7	16	license	license	NOUN
ajlm-2384	7	17	,	,	PUNCT
ajlm-2384	7	18	which	which	PRON
ajlm-2384	7	19	permits	permit	VERB
ajlm-2384	7	20	unrestricted	unrestricted	ADJ
ajlm-2384	7	21	use	use	NOUN
ajlm-2384	7	22	,	,	PUNCT
ajlm-2384	7	23	distribution	distribution	NOUN
ajlm-2384	7	24	,	,	PUNCT
ajlm-2384	7	25	and	and	CCONJ
ajlm-2384	7	26	reproduction	reproduction	NOUN
ajlm-2384	7	27	in	in	ADP
ajlm-2384	7	28	any	any	DET
ajlm-2384	7	29	medium	medium	NOUN
ajlm-2384	7	30	,	,	PUNCT
ajlm-2384	7	31	provided	provide	VERB
ajlm-2384	7	32	the	the	DET
ajlm-2384	7	33	original	original	ADJ
ajlm-2384	7	34	work	work	NOUN
ajlm-2384	7	35	is	be	AUX
ajlm-2384	7	36	properly	properly	ADV
ajlm-2384	7	37	cited	cite	VERB
ajlm-2384	7	38	.	.	PUNCT
ajlm-2384	8	1	abstract	abstract	ADJ
ajlm-2384	8	2	introduction	introduction	NOUN
ajlm-2384	8	3	:	:	PUNCT
ajlm-2384	8	4	maternally	maternally	ADV
ajlm-2384	8	5	inherited	inherit	VERB
ajlm-2384	8	6	diabetes	diabetes	NOUN
ajlm-2384	8	7	and	and	CCONJ
ajlm-2384	8	8	deafness	deafness	NOUN
ajlm-2384	8	9	(	(	PUNCT
ajlm-2384	8	10	midd	midd	NOUN
ajlm-2384	8	11	)	)	PUNCT
ajlm-2384	8	12	is	be	AUX
ajlm-2384	8	13	caused	cause	VERB
ajlm-2384	8	14	by	by	ADP
ajlm-2384	8	15	the	the	DET
ajlm-2384	8	16	m.3243a	m.3243a	NOUN
ajlm-2384	8	17	>	>	NOUN
ajlm-2384	8	18	g	g	NOUN
ajlm-2384	8	19	pathogenic	pathogenic	ADJ
ajlm-2384	8	20	variant	variant	NOUN
ajlm-2384	8	21	in	in	ADP
ajlm-2384	8	22	maternally	maternally	ADV
ajlm-2384	8	23	inherited	inherit	VERB
ajlm-2384	8	24	mitochondrial	mitochondrial	ADJ
ajlm-2384	8	25	dna	dna	NOUN
ajlm-2384	8	26	.	.	PUNCT
ajlm-2384	9	1	diabetes	diabetes	NOUN
ajlm-2384	9	2	is	be	AUX
ajlm-2384	9	3	prevalent	prevalent	ADJ
ajlm-2384	9	4	in	in	ADP
ajlm-2384	9	5	our	our	PRON
ajlm-2384	9	6	setting	setting	NOUN
ajlm-2384	9	7	;	;	PUNCT
ajlm-2384	9	8	however	however	ADV
ajlm-2384	9	9	,	,	PUNCT
ajlm-2384	9	10	midd	midd	PROPN
ajlm-2384	9	11	is	be	AUX
ajlm-2384	9	12	rarely	rarely	ADV
ajlm-2384	9	13	diagnosed	diagnose	VERB
ajlm-2384	9	14	.	.	PUNCT
ajlm-2384	10	1	this	this	DET
ajlm-2384	10	2	study	study	NOUN
ajlm-2384	10	3	,	,	PUNCT
ajlm-2384	10	4	undertaken	undertake	VERB
ajlm-2384	10	5	in	in	ADP
ajlm-2384	10	6	pretoria	pretoria	PROPN
ajlm-2384	10	7	,	,	PUNCT
ajlm-2384	10	8	south	south	PROPN
ajlm-2384	10	9	africa	africa	PROPN
ajlm-2384	10	10	,	,	PUNCT
ajlm-2384	10	11	highlights	highlight	VERB
ajlm-2384	10	12	the	the	DET
ajlm-2384	10	13	variable	variable	ADJ
ajlm-2384	10	14	presentation	presentation	NOUN
ajlm-2384	10	15	of	of	ADP
ajlm-2384	10	16	midd	midd	NOUN
ajlm-2384	10	17	in	in	ADP
ajlm-2384	10	18	different	different	ADJ
ajlm-2384	10	19	patients	patient	NOUN
ajlm-2384	10	20	within	within	ADP
ajlm-2384	10	21	the	the	DET
ajlm-2384	10	22	same	same	ADJ
ajlm-2384	10	23	family	family	NOUN
ajlm-2384	10	24	.	.	PUNCT
ajlm-2384	11	1	case	case	NOUN
ajlm-2384	11	2	presentation	presentation	NOUN
ajlm-2384	11	3	:	:	PUNCT
ajlm-2384	11	4	a	a	DET
ajlm-2384	11	5	45	45	NUM
ajlm-2384	11	6	-	-	PUNCT
ajlm-2384	11	7	year	year	NOUN
ajlm-2384	11	8	-	-	PUNCT
ajlm-2384	11	9	old	old	ADJ
ajlm-2384	11	10	man	man	NOUN
ajlm-2384	11	11	(	(	PUNCT
ajlm-2384	11	12	proband	proband	PROPN
ajlm-2384	11	13	)	)	PUNCT
ajlm-2384	11	14	with	with	ADP
ajlm-2384	11	15	hearing	hearing	NOUN
ajlm-2384	11	16	impairment	impairment	NOUN
ajlm-2384	11	17	was	be	AUX
ajlm-2384	11	18	referred	refer	VERB
ajlm-2384	11	19	to	to	ADP
ajlm-2384	11	20	the	the	DET
ajlm-2384	11	21	endocrine	endocrine	ADJ
ajlm-2384	11	22	unit	unit	NOUN
ajlm-2384	11	23	in	in	ADP
ajlm-2384	11	24	july	july	PROPN
ajlm-2384	11	25	2015	2015	NUM
ajlm-2384	11	26	due	due	ADP
ajlm-2384	11	27	to	to	ADP
ajlm-2384	11	28	poor	poor	ADJ
ajlm-2384	11	29	glycaemic	glycaemic	NOUN
ajlm-2384	11	30	control	control	NOUN
ajlm-2384	11	31	(	(	PUNCT
ajlm-2384	11	32	hba1c	hba1c	NOUN
ajlm-2384	11	33	=	=	SYM
ajlm-2384	11	34	13	13	NUM
ajlm-2384	11	35	%	%	NOUN
ajlm-2384	11	36	)	)	PUNCT
ajlm-2384	11	37	.	.	PUNCT
ajlm-2384	12	1	his	his	PRON
ajlm-2384	12	2	clinical	clinical	ADJ
ajlm-2384	12	3	and	and	CCONJ
ajlm-2384	12	4	biochemical	biochemical	ADJ
ajlm-2384	12	5	features	feature	NOUN
ajlm-2384	12	6	were	be	AUX
ajlm-2384	12	7	in	in	ADP
ajlm-2384	12	8	keeping	keep	VERB
ajlm-2384	12	9	with	with	ADP
ajlm-2384	12	10	midd	midd	NOUN
ajlm-2384	12	11	.	.	PUNCT
ajlm-2384	13	1	a	a	DET
ajlm-2384	13	2	genetic	genetic	ADJ
ajlm-2384	13	3	study	study	NOUN
ajlm-2384	13	4	of	of	ADP
ajlm-2384	13	5	accessible	accessible	ADJ
ajlm-2384	13	6	maternal	maternal	ADJ
ajlm-2384	13	7	relatives	relative	NOUN
ajlm-2384	13	8	was	be	AUX
ajlm-2384	13	9	pursued	pursue	VERB
ajlm-2384	13	10	.	.	PUNCT
ajlm-2384	14	1	his	his	PRON
ajlm-2384	14	2	mother	mother	NOUN
ajlm-2384	14	3	had	have	VERB
ajlm-2384	14	4	difficulty	difficulty	NOUN
ajlm-2384	14	5	hearing	hearing	NOUN
ajlm-2384	14	6	and	and	CCONJ
ajlm-2384	14	7	reportedly	reportedly	ADV
ajlm-2384	14	8	died	die	VERB
ajlm-2384	14	9	from	from	ADP
ajlm-2384	14	10	an	an	DET
ajlm-2384	14	11	unspecified	unspecified	ADJ
ajlm-2384	14	12	cardiovascular	cardiovascular	ADJ
ajlm-2384	14	13	cause	cause	NOUN
ajlm-2384	14	14	.	.	PUNCT
ajlm-2384	15	1	two	two	NUM
ajlm-2384	15	2	sisters	sister	NOUN
ajlm-2384	15	3	with	with	ADP
ajlm-2384	15	4	diabetes	diabetes	NOUN
ajlm-2384	15	5	and	and	CCONJ
ajlm-2384	15	6	deafness	deafness	NOUN
ajlm-2384	15	7	died	die	VERB
ajlm-2384	15	8	of	of	ADP
ajlm-2384	15	9	cardiac	cardiac	ADJ
ajlm-2384	15	10	-	-	PUNCT
ajlm-2384	15	11	related	relate	VERB
ajlm-2384	15	12	conditions	condition	NOUN
ajlm-2384	15	13	.	.	PUNCT
ajlm-2384	16	1	one	one	NUM
ajlm-2384	16	2	nephew	nephew	NOUN
ajlm-2384	16	3	had	have	VERB
ajlm-2384	16	4	diabetes	diabetes	NOUN
ajlm-2384	16	5	(	(	PUNCT
ajlm-2384	16	6	hba1c	hba1c	NOUN
ajlm-2384	16	7	=	=	SYM
ajlm-2384	16	8	7.7	7.7	NUM
ajlm-2384	16	9	%	%	NOUN
ajlm-2384	16	10	)	)	PUNCT
ajlm-2384	16	11	,	,	PUNCT
ajlm-2384	16	12	hearing	hear	VERB
ajlm-2384	16	13	loss	loss	NOUN
ajlm-2384	16	14	and	and	CCONJ
ajlm-2384	16	15	tested	test	VERB
ajlm-2384	16	16	positive	positive	ADJ
ajlm-2384	16	17	for	for	ADP
ajlm-2384	16	18	m.3243a	m.3243a	NOUN
ajlm-2384	16	19	>	>	X
ajlm-2384	16	20	g.	g.	PROPN
ajlm-2384	16	21	a	a	DET
ajlm-2384	16	22	third	third	ADJ
ajlm-2384	16	23	sister	sister	NOUN
ajlm-2384	16	24	tested	test	VERB
ajlm-2384	16	25	positive	positive	ADJ
ajlm-2384	16	26	for	for	ADP
ajlm-2384	16	27	m3243a	m3243a	NOUN
ajlm-2384	16	28	>	>	NOUN
ajlm-2384	16	29	g	g	NOUN
ajlm-2384	16	30	,	,	PUNCT
ajlm-2384	16	31	but	but	CCONJ
ajlm-2384	16	32	aside	aside	ADV
ajlm-2384	16	33	from	from	ADP
ajlm-2384	16	34	bilateral	bilateral	ADJ
ajlm-2384	16	35	mild	mild	ADJ
ajlm-2384	16	36	hearing	hearing	NOUN
ajlm-2384	16	37	loss	loss	NOUN
ajlm-2384	16	38	in	in	ADP
ajlm-2384	16	39	higher	high	ADJ
ajlm-2384	16	40	frequencies	frequency	NOUN
ajlm-2384	16	41	,	,	PUNCT
ajlm-2384	16	42	showed	show	VERB
ajlm-2384	16	43	no	no	DET
ajlm-2384	16	44	other	other	ADJ
ajlm-2384	16	45	signs	sign	NOUN
ajlm-2384	16	46	of	of	ADP
ajlm-2384	16	47	target	target	NOUN
ajlm-2384	16	48	organ	organ	NOUN
ajlm-2384	16	49	damage	damage	NOUN
ajlm-2384	16	50	.	.	PUNCT
ajlm-2384	17	1	her	her	PRON
ajlm-2384	17	2	daughter	daughter	NOUN
ajlm-2384	17	3	developed	develop	VERB
ajlm-2384	17	4	end	end	NOUN
ajlm-2384	17	5	-	-	PUNCT
ajlm-2384	17	6	stage	stage	NOUN
ajlm-2384	17	7	kidney	kidney	NOUN
ajlm-2384	17	8	failure	failure	NOUN
ajlm-2384	17	9	necessitating	necessitate	VERB
ajlm-2384	17	10	a	a	DET
ajlm-2384	17	11	transplant	transplant	NOUN
ajlm-2384	17	12	,	,	PUNCT
ajlm-2384	17	13	while	while	SCONJ
ajlm-2384	17	14	her	her	PRON
ajlm-2384	17	15	son	son	NOUN
ajlm-2384	17	16	had	have	VERB
ajlm-2384	17	17	no	no	DET
ajlm-2384	17	18	biochemical	biochemical	ADJ
ajlm-2384	17	19	abnormalities	abnormality	NOUN
ajlm-2384	17	20	and	and	CCONJ
ajlm-2384	17	21	was	be	AUX
ajlm-2384	17	22	negative	negative	ADJ
ajlm-2384	17	23	for	for	ADP
ajlm-2384	17	24	m.3243a	m.3243a	NOUN
ajlm-2384	17	25	>	>	NOUN
ajlm-2384	17	26	g.	g.	NOUN
ajlm-2384	17	27	management	management	NOUN
ajlm-2384	17	28	and	and	CCONJ
ajlm-2384	17	29	outcome	outcome	NOUN
ajlm-2384	17	30	:	:	PUNCT
ajlm-2384	17	31	a	a	DET
ajlm-2384	17	32	multidisciplinary	multidisciplinary	ADJ
ajlm-2384	17	33	team	team	NOUN
ajlm-2384	17	34	managed	manage	VERB
ajlm-2384	17	35	and	and	CCONJ
ajlm-2384	17	36	screened	screen	VERB
ajlm-2384	17	37	for	for	ADP
ajlm-2384	17	38	complications	complication	NOUN
ajlm-2384	17	39	of	of	ADP
ajlm-2384	17	40	the	the	DET
ajlm-2384	17	41	patient	patient	NOUN
ajlm-2384	17	42	and	and	CCONJ
ajlm-2384	17	43	his	his	PRON
ajlm-2384	17	44	maternal	maternal	ADJ
ajlm-2384	17	45	relatives	relative	NOUN
ajlm-2384	17	46	.	.	PUNCT
ajlm-2384	18	1	proband	proband	PROPN
ajlm-2384	18	2	died	die	VERB
ajlm-2384	18	3	prior	prior	ADV
ajlm-2384	18	4	to	to	ADP
ajlm-2384	18	5	genetic	genetic	ADJ
ajlm-2384	18	6	testing	testing	NOUN
ajlm-2384	18	7	.	.	PUNCT
ajlm-2384	19	1	conclusion	conclusion	NOUN
ajlm-2384	19	2	:	:	PUNCT
ajlm-2384	19	3	most	most	ADJ
ajlm-2384	19	4	midd	midd	X
ajlm-2384	19	5	patients	patient	NOUN
ajlm-2384	19	6	initially	initially	ADV
ajlm-2384	19	7	present	present	VERB
ajlm-2384	19	8	with	with	ADP
ajlm-2384	19	9	symptoms	symptom	NOUN
ajlm-2384	19	10	of	of	ADP
ajlm-2384	19	11	diabetes	diabetes	NOUN
ajlm-2384	19	12	only	only	ADV
ajlm-2384	19	13	,	,	PUNCT
ajlm-2384	19	14	and	and	CCONJ
ajlm-2384	19	15	it	it	PRON
ajlm-2384	19	16	is	be	AUX
ajlm-2384	19	17	probable	probable	ADJ
ajlm-2384	19	18	that	that	SCONJ
ajlm-2384	19	19	many	many	ADJ
ajlm-2384	19	20	cases	case	NOUN
ajlm-2384	19	21	remain	remain	VERB
ajlm-2384	19	22	undiagnosed	undiagnosed	ADJ
ajlm-2384	19	23	.	.	PUNCT
ajlm-2384	20	1	a	a	DET
ajlm-2384	20	2	high	high	ADJ
ajlm-2384	20	3	index	index	NOUN
ajlm-2384	20	4	of	of	ADP
ajlm-2384	20	5	suspicion	suspicion	NOUN
ajlm-2384	20	6	is	be	AUX
ajlm-2384	20	7	necessary	necessary	ADJ
ajlm-2384	20	8	when	when	SCONJ
ajlm-2384	20	9	encountering	encounter	VERB
ajlm-2384	20	10	a	a	DET
ajlm-2384	20	11	family	family	NOUN
ajlm-2384	20	12	history	history	NOUN
ajlm-2384	20	13	of	of	ADP
ajlm-2384	20	14	both	both	DET
ajlm-2384	20	15	diabetes	diabetes	NOUN
ajlm-2384	20	16	and	and	CCONJ
ajlm-2384	20	17	impaired	impaired	ADJ
ajlm-2384	20	18	hearing	hearing	NOUN
ajlm-2384	20	19	,	,	PUNCT
ajlm-2384	20	20	and	and	CCONJ
ajlm-2384	20	21	screening	screen	VERB
ajlm-2384	20	22	should	should	AUX
ajlm-2384	20	23	be	be	AUX
ajlm-2384	20	24	offered	offer	VERB
ajlm-2384	20	25	to	to	ADP
ajlm-2384	20	26	the	the	DET
ajlm-2384	20	27	patient	patient	NOUN
ajlm-2384	20	28	’s	’s	PART
ajlm-2384	20	29	maternal	maternal	ADJ
ajlm-2384	20	30	relatives	relative	NOUN
ajlm-2384	20	31	.	.	PUNCT
ajlm-2384	21	1	what	what	PRON
ajlm-2384	21	2	the	the	DET
ajlm-2384	21	3	study	study	NOUN
ajlm-2384	21	4	adds	add	VERB
ajlm-2384	21	5	:	:	PUNCT
ajlm-2384	21	6	this	this	DET
ajlm-2384	21	7	study	study	NOUN
ajlm-2384	21	8	demonstrates	demonstrate	VERB
ajlm-2384	21	9	the	the	DET
ajlm-2384	21	10	importance	importance	NOUN
ajlm-2384	21	11	of	of	ADP
ajlm-2384	21	12	proper	proper	ADJ
ajlm-2384	21	13	assessment	assessment	NOUN
ajlm-2384	21	14	when	when	SCONJ
ajlm-2384	21	15	evaluating	evaluate	VERB
ajlm-2384	21	16	a	a	DET
ajlm-2384	21	17	patient	patient	NOUN
ajlm-2384	21	18	with	with	ADP
ajlm-2384	21	19	diabetes	diabetes	NOUN
ajlm-2384	21	20	and	and	CCONJ
ajlm-2384	21	21	a	a	DET
ajlm-2384	21	22	family	family	NOUN
ajlm-2384	21	23	history	history	NOUN
ajlm-2384	21	24	of	of	ADP
ajlm-2384	21	25	hearing	hear	VERB
ajlm-2384	21	26	loss	loss	NOUN
ajlm-2384	21	27	.	.	PUNCT
ajlm-2384	22	1	keywords	keyword	NOUN
ajlm-2384	22	2	:	:	PUNCT
ajlm-2384	22	3	diabetes	diabete	NOUN
ajlm-2384	22	4	;	;	PUNCT
ajlm-2384	22	5	mitochondrial	mitochondrial	ADJ
ajlm-2384	22	6	dna	dna	NOUN
ajlm-2384	22	7	;	;	PUNCT
ajlm-2384	22	8	maternally	maternally	ADV
ajlm-2384	22	9	inherited	inherit	VERB
ajlm-2384	22	10	diabetes	diabetes	NOUN
ajlm-2384	22	11	and	and	CCONJ
ajlm-2384	22	12	deafness	deafness	NOUN
ajlm-2384	22	13	;	;	PUNCT
ajlm-2384	22	14	heteroplasmy	heteroplasmy	PROPN
ajlm-2384	22	15	;	;	PUNCT
ajlm-2384	22	16	hearing	hear	VERB
ajlm-2384	22	17	loss	loss	NOUN
ajlm-2384	22	18	.	.	PUNCT
ajlm-2384	23	1	introduction	introduction	NOUN
ajlm-2384	23	2	primary	primary	ADJ
ajlm-2384	23	3	mitochondrial	mitochondrial	ADJ
ajlm-2384	23	4	disease	disease	NOUN
ajlm-2384	23	5	is	be	AUX
ajlm-2384	23	6	a	a	DET
ajlm-2384	23	7	heterogeneous	heterogeneous	ADJ
ajlm-2384	23	8	group	group	NOUN
ajlm-2384	23	9	of	of	ADP
ajlm-2384	23	10	disorders	disorder	NOUN
ajlm-2384	23	11	resulting	result	VERB
ajlm-2384	23	12	from	from	ADP
ajlm-2384	23	13	inherited	inherit	VERB
ajlm-2384	23	14	defects	defect	NOUN
ajlm-2384	23	15	in	in	ADP
ajlm-2384	23	16	mitochondrial	mitochondrial	ADJ
ajlm-2384	23	17	energy	energy	NOUN
ajlm-2384	23	18	production.1	production.1	NOUN
ajlm-2384	23	19	maternally	maternally	ADV
ajlm-2384	23	20	inherited	inherit	VERB
ajlm-2384	23	21	diabetes	diabetes	NOUN
ajlm-2384	23	22	and	and	CCONJ
ajlm-2384	23	23	deafness	deafness	NOUN
ajlm-2384	23	24	(	(	PUNCT
ajlm-2384	23	25	midd	midd	NOUN
ajlm-2384	23	26	)	)	PUNCT
ajlm-2384	23	27	is	be	AUX
ajlm-2384	23	28	a	a	DET
ajlm-2384	23	29	form	form	NOUN
ajlm-2384	23	30	of	of	ADP
ajlm-2384	23	31	primary	primary	ADJ
ajlm-2384	23	32	mitochondrial	mitochondrial	ADJ
ajlm-2384	23	33	disease	disease	NOUN
ajlm-2384	23	34	,	,	PUNCT
ajlm-2384	23	35	characterised	characterise	VERB
ajlm-2384	23	36	by	by	ADP
ajlm-2384	23	37	diabetes	diabetes	NOUN
ajlm-2384	23	38	and	and	CCONJ
ajlm-2384	23	39	progressive	progressive	ADJ
ajlm-2384	23	40	sensorineural	sensorineural	ADJ
ajlm-2384	23	41	hearing	hearing	NOUN
ajlm-2384	23	42	impairment.2	impairment.2	PROPN
ajlm-2384	23	43	it	it	PRON
ajlm-2384	23	44	is	be	AUX
ajlm-2384	23	45	linked	link	VERB
ajlm-2384	23	46	to	to	ADP
ajlm-2384	23	47	various	various	ADJ
ajlm-2384	23	48	pathogenic	pathogenic	ADJ
ajlm-2384	23	49	variants	variant	NOUN
ajlm-2384	23	50	in	in	ADP
ajlm-2384	23	51	mitochondrial	mitochondrial	ADJ
ajlm-2384	23	52	dna	dna	NOUN
ajlm-2384	23	53	(	(	PUNCT
ajlm-2384	23	54	mtdna	mtdna	ADV
ajlm-2384	23	55	)	)	PUNCT
ajlm-2384	23	56	,	,	PUNCT
ajlm-2384	23	57	including	include	VERB
ajlm-2384	23	58	the	the	DET
ajlm-2384	23	59	m.3243a	m.3243a	NOUN
ajlm-2384	23	60	>	>	NOUN
ajlm-2384	23	61	g	g	NOUN
ajlm-2384	23	62	point	point	NOUN
ajlm-2384	23	63	mutation	mutation	NOUN
ajlm-2384	23	64	in	in	ADP
ajlm-2384	23	65	the	the	DET
ajlm-2384	23	66	mt	mt	NOUN
ajlm-2384	23	67	-	-	PUNCT
ajlm-2384	23	68	tl1	tl1	ADJ
ajlm-2384	23	69	gene	gene	NOUN
ajlm-2384	23	70	,	,	PUNCT
ajlm-2384	23	71	which	which	PRON
ajlm-2384	23	72	has	have	AUX
ajlm-2384	23	73	emerged	emerge	VERB
ajlm-2384	23	74	as	as	ADP
ajlm-2384	23	75	the	the	DET
ajlm-2384	23	76	most	most	ADV
ajlm-2384	23	77	common	common	ADJ
ajlm-2384	23	78	cause	cause	NOUN
ajlm-2384	23	79	of	of	ADP
ajlm-2384	23	80	midd	midd	NOUN
ajlm-2384	23	81	,	,	PUNCT
ajlm-2384	23	82	accounting	account	VERB
ajlm-2384	23	83	for	for	ADP
ajlm-2384	23	84	nearly	nearly	ADV
ajlm-2384	23	85	85	85	NUM
ajlm-2384	23	86	%	%	NOUN
ajlm-2384	23	87	of	of	ADP
ajlm-2384	23	88	all	all	DET
ajlm-2384	23	89	cases.3	cases.3	PROPN
ajlm-2384	23	90	other	other	ADJ
ajlm-2384	23	91	features	feature	NOUN
ajlm-2384	23	92	associated	associate	VERB
ajlm-2384	23	93	with	with	ADP
ajlm-2384	23	94	the	the	DET
ajlm-2384	23	95	m.3243a	m.3243a	NOUN
ajlm-2384	23	96	>	>	NOUN
ajlm-2384	23	97	g	g	NOUN
ajlm-2384	23	98	pathogenic	pathogenic	ADJ
ajlm-2384	23	99	variant	variant	NOUN
ajlm-2384	23	100	are	be	AUX
ajlm-2384	23	101	myopathy	myopathy	ADJ
ajlm-2384	23	102	,	,	PUNCT
ajlm-2384	23	103	gastrointestinal	gastrointestinal	ADJ
ajlm-2384	23	104	tract	tract	NOUN
ajlm-2384	23	105	symptoms	symptom	NOUN
ajlm-2384	23	106	,	,	PUNCT
ajlm-2384	23	107	nephropathy	nephropathy	ADJ
ajlm-2384	23	108	,	,	PUNCT
ajlm-2384	23	109	cardiomyopathy	cardiomyopathy	ADJ
ajlm-2384	23	110	,	,	PUNCT
ajlm-2384	23	111	and	and	CCONJ
ajlm-2384	23	112	neuropsychiatric	neuropsychiatric	ADJ
ajlm-2384	23	113	features	feature	NOUN
ajlm-2384	23	114	with	with	ADP
ajlm-2384	23	115	heterogeneous	heterogeneous	ADJ
ajlm-2384	23	116	manifestation	manifestation	NOUN
ajlm-2384	23	117	even	even	ADV
ajlm-2384	23	118	in	in	ADP
ajlm-2384	23	119	individuals	individual	NOUN
ajlm-2384	23	120	within	within	ADP
ajlm-2384	23	121	the	the	DET
ajlm-2384	23	122	same	same	ADJ
ajlm-2384	23	123	family	family	NOUN
ajlm-2384	23	124	due	due	ADP
ajlm-2384	23	125	to	to	ADP
ajlm-2384	23	126	varying	vary	VERB
ajlm-2384	23	127	mtdna	mtdna	X
ajlm-2384	23	128	heteroplasmy	heteroplasmy	PROPN
ajlm-2384	23	129	levels	level	NOUN
ajlm-2384	23	130	between	between	ADP
ajlm-2384	23	131	different	different	ADJ
ajlm-2384	23	132	tissues	tissue	NOUN
ajlm-2384	23	133	,	,	PUNCT
ajlm-2384	23	134	thus	thus	ADV
ajlm-2384	23	135	developing	develop	VERB
ajlm-2384	23	136	different	different	ADJ
ajlm-2384	23	137	phenotypes	phenotype	NOUN
ajlm-2384	23	138	.	.	PUNCT
ajlm-2384	24	1	the	the	DET
ajlm-2384	24	2	estimated	estimate	VERB
ajlm-2384	24	3	prevalence	prevalence	NOUN
ajlm-2384	24	4	of	of	ADP
ajlm-2384	24	5	midd	midd	NOUN
ajlm-2384	24	6	is	be	AUX
ajlm-2384	24	7	between	between	ADP
ajlm-2384	24	8	0.5	0.5	NUM
ajlm-2384	24	9	%	%	NOUN
ajlm-2384	24	10	and	and	CCONJ
ajlm-2384	24	11	5.9	5.9	NUM
ajlm-2384	24	12	%	%	NOUN
ajlm-2384	24	13	among	among	ADP
ajlm-2384	24	14	patients	patient	NOUN
ajlm-2384	24	15	with	with	ADP
ajlm-2384	24	16	diabetes	diabetes	NOUN
ajlm-2384	24	17	mellitus.4	mellitus.4	PROPN
ajlm-2384	24	18	diagnosis	diagnosis	NOUN
ajlm-2384	24	19	of	of	ADP
ajlm-2384	24	20	midd	midd	NOUN
ajlm-2384	24	21	is	be	AUX
ajlm-2384	24	22	important	important	ADJ
ajlm-2384	24	23	to	to	PART
ajlm-2384	24	24	ensure	ensure	VERB
ajlm-2384	24	25	appropriate	appropriate	ADJ
ajlm-2384	24	26	treatment	treatment	NOUN
ajlm-2384	24	27	,	,	PUNCT
ajlm-2384	24	28	continuous	continuous	ADJ
ajlm-2384	24	29	monitoring	monitoring	NOUN
ajlm-2384	24	30	and	and	CCONJ
ajlm-2384	24	31	that	that	SCONJ
ajlm-2384	24	32	maternal	maternal	ADJ
ajlm-2384	24	33	relatives	relative	NOUN
ajlm-2384	24	34	are	be	AUX
ajlm-2384	24	35	identified	identify	VERB
ajlm-2384	24	36	and	and	CCONJ
ajlm-2384	24	37	managed	manage	VERB
ajlm-2384	24	38	in	in	ADP
ajlm-2384	24	39	a	a	DET
ajlm-2384	24	40	timeous	timeous	ADJ
ajlm-2384	24	41	manner	manner	NOUN
ajlm-2384	24	42	.	.	PUNCT
ajlm-2384	25	1	diabetes	diabetes	NOUN
ajlm-2384	25	2	in	in	ADP
ajlm-2384	25	3	midd	midd	NOUN
ajlm-2384	25	4	,	,	PUNCT
ajlm-2384	25	5	unlike	unlike	ADP
ajlm-2384	25	6	in	in	ADP
ajlm-2384	25	7	type	type	NOUN
ajlm-2384	25	8	1	1	NUM
ajlm-2384	25	9	,	,	PUNCT
ajlm-2384	25	10	initially	initially	ADV
ajlm-2384	25	11	responds	respond	VERB
ajlm-2384	25	12	to	to	PART
ajlm-2384	25	13	secretagogues	secretagogue	NOUN
ajlm-2384	25	14	,	,	PUNCT
ajlm-2384	25	15	but	but	CCONJ
ajlm-2384	25	16	may	may	AUX
ajlm-2384	25	17	later	later	ADV
ajlm-2384	25	18	progress	progress	VERB
ajlm-2384	25	19	to	to	PART
ajlm-2384	25	20	require	require	VERB
ajlm-2384	25	21	insulin	insulin	NOUN
ajlm-2384	25	22	for	for	ADP
ajlm-2384	25	23	management	management	NOUN
ajlm-2384	25	24	.	.	PUNCT
ajlm-2384	26	1	metformin	metformin	NOUN
ajlm-2384	26	2	is	be	AUX
ajlm-2384	26	3	not	not	PART
ajlm-2384	26	4	suitable	suitable	ADJ
ajlm-2384	26	5	in	in	ADP
ajlm-2384	26	6	these	these	DET
ajlm-2384	26	7	patients	patient	NOUN
ajlm-2384	26	8	as	as	SCONJ
ajlm-2384	26	9	it	it	PRON
ajlm-2384	26	10	may	may	AUX
ajlm-2384	26	11	cause	cause	VERB
ajlm-2384	26	12	or	or	CCONJ
ajlm-2384	26	13	exacerbate	exacerbate	VERB
ajlm-2384	26	14	lactic	lactic	ADJ
ajlm-2384	26	15	acidosis	acidosis	NOUN
ajlm-2384	26	16	,	,	PUNCT
ajlm-2384	26	17	which	which	PRON
ajlm-2384	26	18	is	be	AUX
ajlm-2384	26	19	a	a	DET
ajlm-2384	26	20	typical	typical	ADJ
ajlm-2384	26	21	finding	finding	NOUN
ajlm-2384	26	22	in	in	ADP
ajlm-2384	26	23	many	many	ADJ
ajlm-2384	26	24	patients	patient	NOUN
ajlm-2384	26	25	with	with	ADP
ajlm-2384	26	26	primary	primary	ADJ
ajlm-2384	26	27	mitochondrial	mitochondrial	NOUN
ajlm-2384	26	28	disease.5	disease.5	VERB
ajlm-2384	26	29	maternally	maternally	ADV
ajlm-2384	26	30	inherited	inherit	VERB
ajlm-2384	26	31	diabetes	diabetes	NOUN
ajlm-2384	26	32	and	and	CCONJ
ajlm-2384	26	33	deafness	deafness	NOUN
ajlm-2384	26	34	is	be	AUX
ajlm-2384	26	35	rarely	rarely	ADV
ajlm-2384	26	36	diagnosed	diagnose	VERB
ajlm-2384	26	37	in	in	ADP
ajlm-2384	26	38	clinical	clinical	ADJ
ajlm-2384	26	39	practice	practice	NOUN
ajlm-2384	26	40	,	,	PUNCT
ajlm-2384	26	41	and	and	CCONJ
ajlm-2384	26	42	it	it	PRON
ajlm-2384	26	43	may	may	AUX
ajlm-2384	26	44	be	be	AUX
ajlm-2384	26	45	missed	miss	VERB
ajlm-2384	26	46	due	due	ADP
ajlm-2384	26	47	to	to	ADP
ajlm-2384	26	48	its	its	PRON
ajlm-2384	26	49	complex	complex	ADJ
ajlm-2384	26	50	genetic	genetic	ADJ
ajlm-2384	26	51	and	and	CCONJ
ajlm-2384	26	52	phenotypic	phenotypic	ADJ
ajlm-2384	26	53	heterogeneity.6	heterogeneity.6	PROPN
ajlm-2384	26	54	while	while	SCONJ
ajlm-2384	26	55	many	many	ADJ
ajlm-2384	26	56	studies	study	NOUN
ajlm-2384	26	57	have	have	AUX
ajlm-2384	26	58	been	be	AUX
ajlm-2384	26	59	conducted	conduct	VERB
ajlm-2384	26	60	in	in	ADP
ajlm-2384	26	61	europe	europe	PROPN
ajlm-2384	26	62	,	,	PUNCT
ajlm-2384	26	63	australia	australia	PROPN
ajlm-2384	26	64	,	,	PUNCT
ajlm-2384	26	65	asia	asia	PROPN
ajlm-2384	26	66	,	,	PUNCT
ajlm-2384	26	67	and	and	CCONJ
ajlm-2384	26	68	north	north	PROPN
ajlm-2384	26	69	america	america	PROPN
ajlm-2384	26	70	,	,	PUNCT
ajlm-2384	26	71	midd	midd	PROPN
ajlm-2384	26	72	remains	remain	VERB
ajlm-2384	26	73	severely	severely	ADV
ajlm-2384	26	74	underdiagnosed	underdiagnosed	ADJ
ajlm-2384	26	75	on	on	ADP
ajlm-2384	26	76	the	the	DET
ajlm-2384	26	77	african	african	ADJ
ajlm-2384	26	78	continent	continent	NOUN
ajlm-2384	26	79	,	,	PUNCT
ajlm-2384	26	80	with	with	ADP
ajlm-2384	26	81	only	only	ADJ
ajlm-2384	26	82	limited	limited	ADJ
ajlm-2384	26	83	studies	study	NOUN
ajlm-2384	26	84	available.7,8,9	available.7,8,9	ADP
ajlm-2384	26	85	in	in	ADP
ajlm-2384	26	86	this	this	DET
ajlm-2384	26	87	context	context	NOUN
ajlm-2384	26	88	,	,	PUNCT
ajlm-2384	26	89	we	we	PRON
ajlm-2384	26	90	describe	describe	VERB
ajlm-2384	26	91	three	three	NUM
ajlm-2384	26	92	generations	generation	NOUN
ajlm-2384	26	93	of	of	ADP
ajlm-2384	26	94	south	south	ADJ
ajlm-2384	26	95	african	african	ADJ
ajlm-2384	26	96	patients	patient	NOUN
ajlm-2384	26	97	with	with	ADP
ajlm-2384	26	98	midd	midd	NOUN
ajlm-2384	26	99	within	within	ADP
ajlm-2384	26	100	the	the	DET
ajlm-2384	26	101	same	same	ADJ
ajlm-2384	26	102	pedigree	pedigree	NOUN
ajlm-2384	26	103	.	.	PUNCT
ajlm-2384	27	1	ethical	ethical	ADJ
ajlm-2384	27	2	considerations	consideration	NOUN
ajlm-2384	27	3	written	write	VERB
ajlm-2384	27	4	consent	consent	NOUN
ajlm-2384	27	5	was	be	AUX
ajlm-2384	27	6	obtained	obtain	VERB
ajlm-2384	27	7	from	from	ADP
ajlm-2384	27	8	the	the	DET
ajlm-2384	27	9	family	family	NOUN
ajlm-2384	27	10	and	and	CCONJ
ajlm-2384	27	11	ethics	ethic	NOUN
ajlm-2384	27	12	approval	approval	NOUN
ajlm-2384	27	13	obtained	obtain	VERB
ajlm-2384	27	14	from	from	ADP
ajlm-2384	27	15	the	the	DET
ajlm-2384	27	16	research	research	NOUN
ajlm-2384	27	17	and	and	CCONJ
ajlm-2384	27	18	ethics	ethic	NOUN
ajlm-2384	27	19	committee	committee	NOUN
ajlm-2384	27	20	at	at	ADP
ajlm-2384	27	21	the	the	DET
ajlm-2384	27	22	university	university	PROPN
ajlm-2384	27	23	of	of	ADP
ajlm-2384	27	24	pretoria	pretoria	PROPN
ajlm-2384	27	25	(	(	PUNCT
ajlm-2384	27	26	no	no	INTJ
ajlm-2384	27	27	.	.	PUNCT
ajlm-2384	27	28	496/2023	496/2023	NUM
ajlm-2384	27	29	)	)	PUNCT
ajlm-2384	27	30	.	.	PUNCT
ajlm-2384	28	1	confidentiality	confidentiality	NOUN
ajlm-2384	28	2	was	be	AUX
ajlm-2384	28	3	ensured	ensure	VERB
ajlm-2384	28	4	by	by	ADP
ajlm-2384	28	5	avoiding	avoid	VERB
ajlm-2384	28	6	any	any	DET
ajlm-2384	28	7	use	use	NOUN
ajlm-2384	28	8	of	of	ADP
ajlm-2384	28	9	names	name	NOUN
ajlm-2384	28	10	,	,	PUNCT
ajlm-2384	28	11	initials	initial	NOUN
ajlm-2384	28	12	,	,	PUNCT
ajlm-2384	28	13	pictures	picture	NOUN
ajlm-2384	28	14	or	or	CCONJ
ajlm-2384	28	15	personal	personal	ADJ
ajlm-2384	28	16	identification	identification	NOUN
ajlm-2384	28	17	numbers	number	NOUN
ajlm-2384	28	18	in	in	ADP
ajlm-2384	28	19	the	the	DET
ajlm-2384	28	20	preparation	preparation	NOUN
ajlm-2384	28	21	of	of	ADP
ajlm-2384	28	22	this	this	DET
ajlm-2384	28	23	case	case	NOUN
ajlm-2384	28	24	study	study	NOUN
ajlm-2384	28	25	.	.	PUNCT
ajlm-2384	29	1	case	case	NOUN
ajlm-2384	29	2	presentation	presentation	NOUN
ajlm-2384	29	3	the	the	DET
ajlm-2384	29	4	proband	proband	NOUN
ajlm-2384	29	5	,	,	PUNCT
ajlm-2384	29	6	a	a	DET
ajlm-2384	29	7	45	45	NUM
ajlm-2384	29	8	-	-	PUNCT
ajlm-2384	29	9	year	year	NOUN
ajlm-2384	29	10	-	-	PUNCT
ajlm-2384	29	11	old	old	ADJ
ajlm-2384	29	12	man	man	NOUN
ajlm-2384	29	13	,	,	PUNCT
ajlm-2384	29	14	was	be	AUX
ajlm-2384	29	15	referred	refer	VERB
ajlm-2384	29	16	to	to	ADP
ajlm-2384	29	17	the	the	DET
ajlm-2384	29	18	endocrine	endocrine	ADJ
ajlm-2384	29	19	unit	unit	NOUN
ajlm-2384	29	20	of	of	ADP
ajlm-2384	29	21	a	a	DET
ajlm-2384	29	22	tertiary	tertiary	ADJ
ajlm-2384	29	23	hospital	hospital	NOUN
ajlm-2384	29	24	in	in	ADP
ajlm-2384	29	25	pretoria	pretoria	PROPN
ajlm-2384	29	26	,	,	PUNCT
ajlm-2384	29	27	south	south	PROPN
ajlm-2384	29	28	africa	africa	PROPN
ajlm-2384	29	29	,	,	PUNCT
ajlm-2384	29	30	in	in	ADP
ajlm-2384	29	31	july	july	PROPN
ajlm-2384	29	32	2015	2015	NUM
ajlm-2384	29	33	due	due	ADP
ajlm-2384	29	34	to	to	ADP
ajlm-2384	29	35	poor	poor	ADJ
ajlm-2384	29	36	glycaemic	glycaemic	NOUN
ajlm-2384	29	37	control	control	NOUN
ajlm-2384	29	38	(	(	PUNCT
ajlm-2384	29	39	glycated	glycate	VERB
ajlm-2384	29	40	haemoglobin	haemoglobin	NOUN
ajlm-2384	29	41	[	[	X
ajlm-2384	29	42	hba1c	hba1c	X
ajlm-2384	29	43	]	]	X
ajlm-2384	29	44	=	=	SYM
ajlm-2384	29	45	13	13	NUM
ajlm-2384	29	46	%	%	NOUN
ajlm-2384	29	47	;	;	PUNCT
ajlm-2384	29	48	abnormal	abnormal	ADJ
ajlm-2384	29	49	>	>	X
ajlm-2384	29	50	6.5	6.5	NUM
ajlm-2384	29	51	%	%	NOUN
ajlm-2384	29	52	)	)	PUNCT
ajlm-2384	29	53	.	.	PUNCT
ajlm-2384	30	1	glycated	glycate	VERB
ajlm-2384	30	2	haemoglobin	haemoglobin	PROPN
ajlm-2384	30	3	was	be	AUX
ajlm-2384	30	4	assessed	assess	VERB
ajlm-2384	30	5	using	use	VERB
ajlm-2384	30	6	the	the	DET
ajlm-2384	30	7	national	national	ADJ
ajlm-2384	30	8	glycohaemoglobin	glycohaemoglobin	PROPN
ajlm-2384	30	9	standardization	standardization	NOUN
ajlm-2384	30	10	program	program	NOUN
ajlm-2384	30	11	-	-	PUNCT
ajlm-2384	30	12	certified	certify	VERB
ajlm-2384	30	13	high	high	ADJ
ajlm-2384	30	14	performance	performance	NOUN
ajlm-2384	30	15	liquid	liquid	NOUN
ajlm-2384	30	16	chromatography	chromatography	NOUN
ajlm-2384	30	17	(	(	PUNCT
ajlm-2384	30	18	bio	bio	NOUN
ajlm-2384	30	19	-	-	PROPN
ajlm-2384	30	20	rad	rad	PROPN
ajlm-2384	30	21	,	,	PUNCT
ajlm-2384	30	22	hercules	hercules	PROPN
ajlm-2384	30	23	,	,	PUNCT
ajlm-2384	30	24	california	california	PROPN
ajlm-2384	30	25	,	,	PUNCT
ajlm-2384	30	26	united	united	PROPN
ajlm-2384	30	27	states	states	PROPN
ajlm-2384	30	28	)	)	PUNCT
ajlm-2384	30	29	method	method	NOUN
ajlm-2384	30	30	.	.	PUNCT
ajlm-2384	31	1	he	he	PRON
ajlm-2384	31	2	was	be	AUX
ajlm-2384	31	3	diagnosed	diagnose	VERB
ajlm-2384	31	4	with	with	ADP
ajlm-2384	31	5	diabetes	diabetes	NOUN
ajlm-2384	31	6	(	(	PUNCT
ajlm-2384	31	7	presumed	presume	VERB
ajlm-2384	31	8	type	type	NOUN
ajlm-2384	31	9	2	2	NUM
ajlm-2384	31	10	)	)	PUNCT
ajlm-2384	31	11	,	,	PUNCT
ajlm-2384	31	12	at	at	ADP
ajlm-2384	31	13	age	age	NOUN
ajlm-2384	31	14	37	37	NUM
ajlm-2384	31	15	years	year	NOUN
ajlm-2384	31	16	,	,	PUNCT
ajlm-2384	31	17	and	and	CCONJ
ajlm-2384	31	18	hearing	hearing	NOUN
ajlm-2384	31	19	impairment	impairment	NOUN
ajlm-2384	31	20	was	be	AUX
ajlm-2384	31	21	noted	note	VERB
ajlm-2384	31	22	a	a	DET
ajlm-2384	31	23	year	year	NOUN
ajlm-2384	31	24	later	later	ADV
ajlm-2384	31	25	.	.	PUNCT
ajlm-2384	32	1	he	he	PRON
ajlm-2384	32	2	had	have	VERB
ajlm-2384	32	3	a	a	DET
ajlm-2384	32	4	previous	previous	ADJ
ajlm-2384	32	5	admission	admission	NOUN
ajlm-2384	32	6	for	for	ADP
ajlm-2384	32	7	congestive	congestive	ADJ
ajlm-2384	32	8	cardiac	cardiac	ADJ
ajlm-2384	32	9	failure	failure	NOUN
ajlm-2384	32	10	and	and	CCONJ
ajlm-2384	32	11	an	an	DET
ajlm-2384	32	12	echocardiogram	echocardiogram	NOUN
ajlm-2384	32	13	revealed	reveal	VERB
ajlm-2384	32	14	an	an	DET
ajlm-2384	32	15	ejection	ejection	NOUN
ajlm-2384	32	16	fraction	fraction	NOUN
ajlm-2384	32	17	of	of	ADP
ajlm-2384	32	18	13	13	NUM
ajlm-2384	32	19	%	%	NOUN
ajlm-2384	32	20	–	–	PUNCT
ajlm-2384	32	21	15	15	NUM
ajlm-2384	32	22	%	%	NOUN
ajlm-2384	32	23	.	.	PUNCT
ajlm-2384	33	1	at	at	ADP
ajlm-2384	33	2	age	age	NOUN
ajlm-2384	33	3	42	42	NUM
ajlm-2384	33	4	years	year	NOUN
ajlm-2384	33	5	,	,	PUNCT
ajlm-2384	33	6	he	he	PRON
ajlm-2384	33	7	developed	develop	VERB
ajlm-2384	33	8	proximal	proximal	ADJ
ajlm-2384	33	9	myopathy	myopathy	ADJ
ajlm-2384	33	10	,	,	PUNCT
ajlm-2384	33	11	leading	lead	VERB
ajlm-2384	33	12	to	to	ADP
ajlm-2384	33	13	reliance	reliance	NOUN
ajlm-2384	33	14	on	on	ADP
ajlm-2384	33	15	a	a	DET
ajlm-2384	33	16	wheelchair	wheelchair	NOUN
ajlm-2384	33	17	for	for	ADP
ajlm-2384	33	18	mobility	mobility	NOUN
ajlm-2384	33	19	.	.	PUNCT
ajlm-2384	34	1	he	he	PRON
ajlm-2384	34	2	was	be	AUX
ajlm-2384	34	3	grossly	grossly	ADV
ajlm-2384	34	4	underweight	underweight	ADJ
ajlm-2384	34	5	,	,	PUNCT
ajlm-2384	34	6	with	with	ADP
ajlm-2384	34	7	a	a	DET
ajlm-2384	34	8	body	body	NOUN
ajlm-2384	34	9	mass	mass	NOUN
ajlm-2384	34	10	index	index	NOUN
ajlm-2384	34	11	of	of	ADP
ajlm-2384	34	12	14.48	14.48	NUM
ajlm-2384	34	13	kg	kg	NOUN
ajlm-2384	34	14	/	/	SYM
ajlm-2384	34	15	m2	m2	PROPN
ajlm-2384	34	16	.	.	PUNCT
ajlm-2384	35	1	the	the	DET
ajlm-2384	35	2	patient	patient	NOUN
ajlm-2384	35	3	had	have	AUX
ajlm-2384	35	4	established	establish	VERB
ajlm-2384	35	5	renal	renal	ADJ
ajlm-2384	35	6	impairment	impairment	NOUN
ajlm-2384	35	7	(	(	PUNCT
ajlm-2384	35	8	urea	urea	NOUN
ajlm-2384	35	9	=	=	SYM
ajlm-2384	35	10	18.8	18.8	NUM
ajlm-2384	35	11	mmol	mmol	NOUN
ajlm-2384	35	12	/	/	SYM
ajlm-2384	35	13	l	l	NOUN
ajlm-2384	35	14	,	,	PUNCT
ajlm-2384	35	15	reference	reference	NOUN
ajlm-2384	35	16	interval	interval	NOUN
ajlm-2384	35	17	=	=	PUNCT
ajlm-2384	35	18	2.1–7.1	2.1–7.1	X
ajlm-2384	35	19	;	;	PUNCT
ajlm-2384	35	20	creatinine	creatinine	NOUN
ajlm-2384	35	21	=	=	NOUN
ajlm-2384	35	22	139	139	NUM
ajlm-2384	35	23	µmol	µmol	ADP
ajlm-2384	35	24	/	/	SYM
ajlm-2384	35	25	l	l	NOUN
ajlm-2384	35	26	,	,	PUNCT
ajlm-2384	35	27	reference	reference	NOUN
ajlm-2384	35	28	interval	interval	NOUN
ajlm-2384	35	29	=	=	PROPN
ajlm-2384	35	30	64–104	64–104	PROPN
ajlm-2384	35	31	)	)	PUNCT
ajlm-2384	35	32	,	,	PUNCT
ajlm-2384	35	33	and	and	CCONJ
ajlm-2384	35	34	an	an	DET
ajlm-2384	35	35	estimated	estimate	VERB
ajlm-2384	35	36	glomerular	glomerular	ADJ
ajlm-2384	35	37	filtration	filtration	NOUN
ajlm-2384	35	38	rate	rate	NOUN
ajlm-2384	35	39	of	of	ADP
ajlm-2384	35	40	47	47	NUM
ajlm-2384	35	41	ml	ml	NOUN
ajlm-2384	35	42	/	/	SYM
ajlm-2384	35	43	min	min	NOUN
ajlm-2384	35	44	per	per	ADP
ajlm-2384	35	45	1.73	1.73	NUM
ajlm-2384	35	46	m2	m2	PROPN
ajlm-2384	35	47	(	(	PUNCT
ajlm-2384	35	48	chronic	chronic	ADJ
ajlm-2384	35	49	kidney	kidney	NOUN
ajlm-2384	35	50	disease	disease	NOUN
ajlm-2384	35	51	,	,	PUNCT
ajlm-2384	35	52	stage	stage	NOUN
ajlm-2384	35	53	3)10	3)10	NUM
ajlm-2384	35	54	with	with	ADP
ajlm-2384	35	55	frank	frank	PROPN
ajlm-2384	35	56	proteinuria	proteinuria	PROPN
ajlm-2384	35	57	.	.	PUNCT
ajlm-2384	36	1	urea	urea	PROPN
ajlm-2384	36	2	was	be	AUX
ajlm-2384	36	3	analysed	analyse	VERB
ajlm-2384	36	4	using	use	VERB
ajlm-2384	36	5	the	the	DET
ajlm-2384	36	6	urease	urease	ADJ
ajlm-2384	36	7	enzyme	enzyme	NOUN
ajlm-2384	36	8	assay	assay	VERB
ajlm-2384	36	9	,	,	PUNCT
ajlm-2384	36	10	creatinine	creatinine	NOUN
ajlm-2384	36	11	the	the	DET
ajlm-2384	36	12	alkaline	alkaline	NOUN
ajlm-2384	36	13	picrate	picrate	NOUN
ajlm-2384	36	14	while	while	SCONJ
ajlm-2384	36	15	urine	urine	NOUN
ajlm-2384	36	16	protein	protein	NOUN
ajlm-2384	36	17	was	be	AUX
ajlm-2384	36	18	tested	test	VERB
ajlm-2384	36	19	with	with	ADP
ajlm-2384	36	20	the	the	DET
ajlm-2384	36	21	turbidimetric	turbidimetric	ADJ
ajlm-2384	36	22	method	method	NOUN
ajlm-2384	36	23	that	that	PRON
ajlm-2384	36	24	utilises	utilise	VERB
ajlm-2384	36	25	benzethonium	benzethonium	PROPN
ajlm-2384	36	26	chloride	chloride	PROPN
ajlm-2384	36	27	(	(	PUNCT
ajlm-2384	36	28	abbott	abbott	PROPN
ajlm-2384	36	29	laboratories	laboratories	PROPN
ajlm-2384	36	30	,	,	PUNCT
ajlm-2384	36	31	chicago	chicago	PROPN
ajlm-2384	36	32	,	,	PUNCT
ajlm-2384	36	33	illinois	illinois	PROPN
ajlm-2384	36	34	,	,	PUNCT
ajlm-2384	36	35	united	united	PROPN
ajlm-2384	36	36	states	states	PROPN
ajlm-2384	36	37	)	)	PUNCT
ajlm-2384	36	38	(	(	PUNCT
ajlm-2384	36	39	table	table	NOUN
ajlm-2384	36	40	1	1	NUM
ajlm-2384	36	41	)	)	PUNCT
ajlm-2384	36	42	.	.	PUNCT
ajlm-2384	37	1	type	type	NOUN
ajlm-2384	37	2	1	1	NUM
ajlm-2384	37	3	diabetes	diabetes	NOUN
ajlm-2384	37	4	mellitus	mellitus	NOUN
ajlm-2384	37	5	was	be	AUX
ajlm-2384	37	6	excluded	exclude	VERB
ajlm-2384	37	7	(	(	PUNCT
ajlm-2384	37	8	anti	anti	ADJ
ajlm-2384	37	9	-	-	ADJ
ajlm-2384	37	10	glutamic	glutamic	ADJ
ajlm-2384	37	11	acid	acid	NOUN
ajlm-2384	37	12	decarboxylase	decarboxylase	NOUN
ajlm-2384	37	13	and	and	CCONJ
ajlm-2384	37	14	islets	islet	VERB
ajlm-2384	37	15	tyrosine	tyrosine	NOUN
ajlm-2384	37	16	phosphatase	phosphatase	NOUN
ajlm-2384	37	17	2	2	NUM
ajlm-2384	37	18	antibodies	antibody	NOUN
ajlm-2384	37	19	were	be	AUX
ajlm-2384	37	20	negative	negative	ADJ
ajlm-2384	37	21	)	)	PUNCT
ajlm-2384	37	22	,	,	PUNCT
ajlm-2384	37	23	and	and	CCONJ
ajlm-2384	37	24	c	c	X
ajlm-2384	37	25	-	-	PUNCT
ajlm-2384	37	26	peptide	peptide	NOUN
ajlm-2384	37	27	levels	level	NOUN
ajlm-2384	37	28	were	be	AUX
ajlm-2384	37	29	normal	normal	ADJ
ajlm-2384	37	30	(	(	PUNCT
ajlm-2384	37	31	2.6	2.6	NUM
ajlm-2384	37	32	µg	µg	NOUN
ajlm-2384	37	33	/	/	SYM
ajlm-2384	37	34	l	l	NOUN
ajlm-2384	37	35	;	;	PUNCT
ajlm-2384	37	36	reference	reference	NOUN
ajlm-2384	37	37	interval	interval	NOUN
ajlm-2384	37	38	=	=	PUNCT
ajlm-2384	37	39	0.9–7.1	0.9–7.1	NUM
ajlm-2384	37	40	)	)	PUNCT
ajlm-2384	37	41	,	,	PUNCT
ajlm-2384	37	42	suggesting	suggest	VERB
ajlm-2384	37	43	residual	residual	ADJ
ajlm-2384	37	44	insulin	insulin	NOUN
ajlm-2384	37	45	secretion	secretion	NOUN
ajlm-2384	37	46	.	.	PUNCT
ajlm-2384	38	1	as	as	SCONJ
ajlm-2384	38	2	c	c	NOUN
ajlm-2384	38	3	-	-	PUNCT
ajlm-2384	38	4	peptide	peptide	NOUN
ajlm-2384	38	5	levels	level	NOUN
ajlm-2384	38	6	may	may	AUX
ajlm-2384	38	7	be	be	AUX
ajlm-2384	38	8	decreased	decrease	VERB
ajlm-2384	38	9	in	in	ADP
ajlm-2384	38	10	patients	patient	NOUN
ajlm-2384	38	11	with	with	ADP
ajlm-2384	38	12	kidney	kidney	NOUN
ajlm-2384	38	13	failure	failure	NOUN
ajlm-2384	38	14	,	,	PUNCT
ajlm-2384	38	15	looking	look	VERB
ajlm-2384	38	16	for	for	ADP
ajlm-2384	38	17	features	feature	NOUN
ajlm-2384	38	18	of	of	ADP
ajlm-2384	38	19	monogenic	monogenic	ADJ
ajlm-2384	38	20	diabetes	diabetes	NOUN
ajlm-2384	38	21	can	can	AUX
ajlm-2384	38	22	assist	assist	VERB
ajlm-2384	38	23	to	to	PART
ajlm-2384	38	24	reduce	reduce	VERB
ajlm-2384	38	25	misclassification.11	misclassification.11	PROPN
ajlm-2384	38	26	he	he	PRON
ajlm-2384	38	27	had	have	AUX
ajlm-2384	38	28	not	not	PART
ajlm-2384	38	29	experienced	experience	VERB
ajlm-2384	38	30	any	any	DET
ajlm-2384	38	31	episodes	episode	NOUN
ajlm-2384	38	32	of	of	ADP
ajlm-2384	38	33	diabetic	diabetic	ADJ
ajlm-2384	38	34	ketoacidosis	ketoacidosis	NOUN
ajlm-2384	38	35	.	.	PUNCT
ajlm-2384	39	1	his	his	PRON
ajlm-2384	39	2	clinical	clinical	ADJ
ajlm-2384	39	3	and	and	CCONJ
ajlm-2384	39	4	biochemical	biochemical	ADJ
ajlm-2384	39	5	features	feature	NOUN
ajlm-2384	39	6	were	be	AUX
ajlm-2384	39	7	in	in	ADP
ajlm-2384	39	8	keeping	keep	VERB
ajlm-2384	39	9	with	with	ADP
ajlm-2384	39	10	midd	midd	NOUN
ajlm-2384	39	11	.	.	PUNCT
ajlm-2384	39	12	table	table	NOUN
ajlm-2384	39	13	1	1	NUM
ajlm-2384	39	14	:	:	PUNCT
ajlm-2384	39	15	 	 	SPACE
ajlm-2384	39	16	laboratory	laboratory	NOUN
ajlm-2384	39	17	results	result	NOUN
ajlm-2384	39	18	of	of	ADP
ajlm-2384	39	19	the	the	DET
ajlm-2384	39	20	proband	proband	NOUN
ajlm-2384	39	21	with	with	ADP
ajlm-2384	39	22	maternally	maternally	ADV
ajlm-2384	39	23	inherited	inherit	VERB
ajlm-2384	39	24	diabetes	diabetes	NOUN
ajlm-2384	39	25	and	and	CCONJ
ajlm-2384	39	26	deafness	deafness	NOUN
ajlm-2384	39	27	for	for	ADP
ajlm-2384	39	28	assessment	assessment	NOUN
ajlm-2384	39	29	of	of	ADP
ajlm-2384	39	30	complications	complication	NOUN
ajlm-2384	39	31	,	,	PUNCT
ajlm-2384	39	32	obtained	obtain	VERB
ajlm-2384	39	33	between	between	ADP
ajlm-2384	39	34	july	july	PROPN
ajlm-2384	39	35	2015	2015	NUM
ajlm-2384	39	36	and	and	CCONJ
ajlm-2384	39	37	june	june	PROPN
ajlm-2384	39	38	2016	2016	NUM
ajlm-2384	39	39	,	,	PUNCT
ajlm-2384	39	40	south	south	PROPN
ajlm-2384	39	41	africa	africa	PROPN
ajlm-2384	39	42	.	.	PUNCT
ajlm-2384	40	1	genetic	genetic	ADJ
ajlm-2384	40	2	investigations	investigation	NOUN
ajlm-2384	40	3	were	be	AUX
ajlm-2384	40	4	pursued	pursue	VERB
ajlm-2384	40	5	for	for	ADP
ajlm-2384	40	6	some	some	PRON
ajlm-2384	40	7	of	of	ADP
ajlm-2384	40	8	his	his	PRON
ajlm-2384	40	9	maternal	maternal	ADJ
ajlm-2384	40	10	relatives	relative	NOUN
ajlm-2384	40	11	.	.	PUNCT
ajlm-2384	41	1	genetic	genetic	ADJ
ajlm-2384	41	2	investigation	investigation	NOUN
ajlm-2384	41	3	of	of	ADP
ajlm-2384	41	4	the	the	DET
ajlm-2384	41	5	proband	proband	NOUN
ajlm-2384	41	6	was	be	AUX
ajlm-2384	41	7	not	not	PART
ajlm-2384	41	8	done	do	VERB
ajlm-2384	41	9	as	as	SCONJ
ajlm-2384	41	10	the	the	DET
ajlm-2384	41	11	patient	patient	NOUN
ajlm-2384	41	12	demised	demise	VERB
ajlm-2384	41	13	prior	prior	ADV
ajlm-2384	41	14	to	to	ADP
ajlm-2384	41	15	testing	testing	NOUN
ajlm-2384	41	16	.	.	PUNCT
ajlm-2384	42	1	only	only	ADV
ajlm-2384	42	2	one	one	NUM
ajlm-2384	42	3	of	of	ADP
ajlm-2384	42	4	his	his	PRON
ajlm-2384	42	5	siblings	sibling	NOUN
ajlm-2384	42	6	and	and	CCONJ
ajlm-2384	42	7	two	two	NUM
ajlm-2384	42	8	of	of	ADP
ajlm-2384	42	9	their	their	PRON
ajlm-2384	42	10	children	child	NOUN
ajlm-2384	42	11	were	be	AUX
ajlm-2384	42	12	available	available	ADJ
ajlm-2384	42	13	for	for	ADP
ajlm-2384	42	14	testing	testing	NOUN
ajlm-2384	42	15	.	.	PUNCT
ajlm-2384	43	1	the	the	DET
ajlm-2384	43	2	presence	presence	NOUN
ajlm-2384	43	3	of	of	ADP
ajlm-2384	43	4	the	the	DET
ajlm-2384	43	5	m.3243a	m.3243a	NOUN
ajlm-2384	43	6	>	>	NOUN
ajlm-2384	43	7	g	g	NOUN
ajlm-2384	43	8	variant	variant	NOUN
ajlm-2384	43	9	was	be	AUX
ajlm-2384	43	10	investigated	investigate	VERB
ajlm-2384	43	11	using	use	VERB
ajlm-2384	43	12	polymerase	polymerase	NOUN
ajlm-2384	43	13	chain	chain	NOUN
ajlm-2384	43	14	reaction	reaction	NOUN
ajlm-2384	43	15	(	(	PUNCT
ajlm-2384	43	16	pcr	pcr	NOUN
ajlm-2384	43	17	)	)	PUNCT
ajlm-2384	43	18	followed	follow	VERB
ajlm-2384	43	19	by	by	ADP
ajlm-2384	43	20	the	the	DET
ajlm-2384	43	21	restriction	restriction	NOUN
ajlm-2384	43	22	fragment	fragment	NOUN
ajlm-2384	43	23	length	length	NOUN
ajlm-2384	43	24	polymorphism	polymorphism	NOUN
ajlm-2384	43	25	method	method	NOUN
ajlm-2384	43	26	with	with	ADP
ajlm-2384	43	27	apai	apai	NOUN
ajlm-2384	43	28	(	(	PUNCT
ajlm-2384	43	29	thermo	thermo	NOUN
ajlm-2384	43	30	scientific	scientific	NOUN
ajlm-2384	43	31	,	,	PUNCT
ajlm-2384	43	32	waltham	waltham	PROPN
ajlm-2384	43	33	,	,	PUNCT
ajlm-2384	43	34	massachusetts	massachusetts	PROPN
ajlm-2384	43	35	,	,	PUNCT
ajlm-2384	43	36	united	united	PROPN
ajlm-2384	43	37	states	states	PROPN
ajlm-2384	43	38	)	)	PUNCT
ajlm-2384	43	39	in	in	ADP
ajlm-2384	43	40	dna	dna	PROPN
ajlm-2384	43	41	extracted	extract	VERB
ajlm-2384	43	42	from	from	ADP
ajlm-2384	43	43	urine	urine	NOUN
ajlm-2384	43	44	samples	sample	NOUN
ajlm-2384	43	45	.	.	PUNCT
ajlm-2384	44	1	generated	generate	VERB
ajlm-2384	44	2	fragments	fragment	NOUN
ajlm-2384	44	3	were	be	AUX
ajlm-2384	44	4	compared	compare	VERB
ajlm-2384	44	5	against	against	ADP
ajlm-2384	44	6	a	a	DET
ajlm-2384	44	7	generuler	generuler	NOUN
ajlm-2384	44	8	dna	dna	NOUN
ajlm-2384	44	9	ladder	ladder	NOUN
ajlm-2384	44	10	mix	mix	NOUN
ajlm-2384	44	11	(	(	PUNCT
ajlm-2384	44	12	thermo	thermo	NOUN
ajlm-2384	44	13	scientific	scientific	NOUN
ajlm-2384	44	14	,	,	PUNCT
ajlm-2384	44	15	waltham	waltham	PROPN
ajlm-2384	44	16	,	,	PUNCT
ajlm-2384	44	17	massachusetts	massachusetts	PROPN
ajlm-2384	44	18	,	,	PUNCT
ajlm-2384	44	19	united	united	PROPN
ajlm-2384	44	20	states	states	PROPN
ajlm-2384	44	21	)	)	PUNCT
ajlm-2384	44	22	(	(	PUNCT
ajlm-2384	44	23	figure	figure	NOUN
ajlm-2384	44	24	1	1	NUM
ajlm-2384	44	25	)	)	PUNCT
ajlm-2384	44	26	.	.	PUNCT
ajlm-2384	45	1	figure	figure	VERB
ajlm-2384	45	2	1	1	NUM
ajlm-2384	45	3	:	:	PUNCT
ajlm-2384	45	4	restriction	restriction	NOUN
ajlm-2384	45	5	enzyme	enzyme	NOUN
ajlm-2384	45	6	digest	digest	NOUN
ajlm-2384	45	7	results	result	NOUN
ajlm-2384	45	8	from	from	ADP
ajlm-2384	45	9	the	the	DET
ajlm-2384	45	10	maternal	maternal	ADJ
ajlm-2384	45	11	nephew	nephew	NOUN
ajlm-2384	45	12	(	(	PUNCT
ajlm-2384	45	13	iii	iii	NOUN
ajlm-2384	45	14	7	7	NUM
ajlm-2384	45	15	)	)	PUNCT
ajlm-2384	45	16	(	(	PUNCT
ajlm-2384	45	17	lane	lane	NOUN
ajlm-2384	45	18	2	2	NUM
ajlm-2384	45	19	,	,	PUNCT
ajlm-2384	45	20	in	in	ADP
ajlm-2384	45	21	gel	gel	NOUN
ajlm-2384	45	22	image	image	NOUN
ajlm-2384	46	1	[	[	X
ajlm-2384	46	2	a	a	X
ajlm-2384	46	3	]	]	X
ajlm-2384	46	4	)	)	PUNCT
ajlm-2384	46	5	,	,	PUNCT
ajlm-2384	46	6	and	and	CCONJ
ajlm-2384	46	7	sister	sister	NOUN
ajlm-2384	46	8	(	(	PUNCT
ajlm-2384	46	9	ii	ii	NOUN
ajlm-2384	46	10	4	4	NUM
ajlm-2384	46	11	)	)	PUNCT
ajlm-2384	46	12	(	(	PUNCT
ajlm-2384	46	13	lane	lane	NOUN
ajlm-2384	46	14	2	2	NUM
ajlm-2384	46	15	in	in	ADP
ajlm-2384	46	16	[	[	X
ajlm-2384	46	17	b	b	X
ajlm-2384	46	18	]	]	X
ajlm-2384	46	19	)	)	PUNCT
ajlm-2384	46	20	of	of	ADP
ajlm-2384	46	21	proband	proband	NOUN
ajlm-2384	46	22	with	with	ADP
ajlm-2384	46	23	maternally	maternally	ADV
ajlm-2384	46	24	inherited	inherit	VERB
ajlm-2384	46	25	diabetes	diabetes	NOUN
ajlm-2384	46	26	and	and	CCONJ
ajlm-2384	46	27	deafness	deafness	NOUN
ajlm-2384	46	28	in	in	ADP
ajlm-2384	46	29	south	south	PROPN
ajlm-2384	46	30	africa	africa	PROPN
ajlm-2384	46	31	,	,	PUNCT
ajlm-2384	46	32	2016	2016	NUM
ajlm-2384	46	33	.	.	PUNCT
ajlm-2384	47	1	the	the	DET
ajlm-2384	47	2	m.3243a	m.3243a	NOUN
ajlm-2384	47	3	>	>	NOUN
ajlm-2384	47	4	g	g	NOUN
ajlm-2384	47	5	variant	variant	NOUN
ajlm-2384	47	6	creates	create	VERB
ajlm-2384	47	7	an	an	DET
ajlm-2384	47	8	apai	apai	NOUN
ajlm-2384	47	9	restriction	restriction	NOUN
ajlm-2384	47	10	site	site	NOUN
ajlm-2384	47	11	in	in	ADP
ajlm-2384	47	12	the	the	DET
ajlm-2384	47	13	407	407	NUM
ajlm-2384	47	14	bp	bp	PROPN
ajlm-2384	47	15	pcr	pcr	PROPN
ajlm-2384	47	16	amplicon	amplicon	NOUN
ajlm-2384	47	17	,	,	PUNCT
ajlm-2384	47	18	resulting	result	VERB
ajlm-2384	47	19	in	in	ADP
ajlm-2384	47	20	174	174	NUM
ajlm-2384	47	21	bp	bp	PROPN
ajlm-2384	47	22	and	and	CCONJ
ajlm-2384	47	23	233	233	NUM
ajlm-2384	47	24	bp	bp	NOUN
ajlm-2384	47	25	fragments	fragment	NOUN
ajlm-2384	47	26	in	in	ADP
ajlm-2384	47	27	affected	affected	ADJ
ajlm-2384	47	28	patients	patient	NOUN
ajlm-2384	47	29	.	.	PUNCT
ajlm-2384	48	1	in	in	ADP
ajlm-2384	48	2	unaffected	unaffected	ADJ
ajlm-2384	48	3	individuals	individual	NOUN
ajlm-2384	48	4	there	there	PRON
ajlm-2384	48	5	is	be	VERB
ajlm-2384	48	6	407	407	NUM
ajlm-2384	48	7	bp	bp	NOUN
ajlm-2384	48	8	only	only	ADV
ajlm-2384	48	9	(	(	PUNCT
ajlm-2384	48	10	restriction	restriction	NOUN
ajlm-2384	48	11	enzyme	enzyme	NOUN
ajlm-2384	48	12	did	do	AUX
ajlm-2384	48	13	not	not	PART
ajlm-2384	48	14	cut	cut	VERB
ajlm-2384	48	15	)	)	PUNCT
ajlm-2384	48	16	and	and	CCONJ
ajlm-2384	48	17	affected	affect	VERB
ajlm-2384	48	18	(	(	PUNCT
ajlm-2384	48	19	heteroplasmic	heteroplasmic	ADJ
ajlm-2384	48	20	)	)	PUNCT
ajlm-2384	48	21	individuals	individual	NOUN
ajlm-2384	48	22	have	have	VERB
ajlm-2384	48	23	three	three	NUM
ajlm-2384	48	24	bands	band	NOUN
ajlm-2384	48	25	(	(	PUNCT
ajlm-2384	48	26	wild	wild	ADJ
ajlm-2384	48	27	type	type	NOUN
ajlm-2384	48	28	[	[	X
ajlm-2384	48	29	407	407	NUM
ajlm-2384	48	30	bp	bp	NOUN
ajlm-2384	48	31	]	]	PUNCT
ajlm-2384	48	32	and	and	CCONJ
ajlm-2384	48	33	two	two	NUM
ajlm-2384	48	34	minor	minor	ADJ
ajlm-2384	48	35	bands	band	NOUN
ajlm-2384	48	36	[	[	X
ajlm-2384	48	37	174	174	NUM
ajlm-2384	48	38	bp	bp	PROPN
ajlm-2384	48	39	and	and	CCONJ
ajlm-2384	48	40	233	233	NUM
ajlm-2384	48	41	bp	bp	NOUN
ajlm-2384	48	42	]	]	PUNCT
ajlm-2384	48	43	)	)	PUNCT
ajlm-2384	48	44	.	.	PUNCT
ajlm-2384	49	1	lanes	lane	NOUN
ajlm-2384	49	2	1	1	NUM
ajlm-2384	49	3	(	(	PUNCT
ajlm-2384	49	4	both	both	PRON
ajlm-2384	49	5	a	a	PRON
ajlm-2384	49	6	and	and	CCONJ
ajlm-2384	49	7	b	b	NOUN
ajlm-2384	49	8	)	)	PUNCT
ajlm-2384	49	9	,	,	PUNCT
ajlm-2384	49	10	and	and	CCONJ
ajlm-2384	49	11	3	3	NUM
ajlm-2384	49	12	and	and	CCONJ
ajlm-2384	49	13	4	4	NUM
ajlm-2384	49	14	(	(	PUNCT
ajlm-2384	49	15	in	in	ADP
ajlm-2384	49	16	a	a	PRON
ajlm-2384	49	17	)	)	PUNCT
ajlm-2384	49	18	were	be	AUX
ajlm-2384	49	19	other	other	ADJ
ajlm-2384	49	20	patients	patient	NOUN
ajlm-2384	49	21	that	that	PRON
ajlm-2384	49	22	tested	test	VERB
ajlm-2384	49	23	negative	negative	ADJ
ajlm-2384	49	24	for	for	ADP
ajlm-2384	49	25	the	the	DET
ajlm-2384	49	26	variant	variant	NOUN
ajlm-2384	49	27	.	.	PUNCT
ajlm-2384	50	1	lane	lane	NOUN
ajlm-2384	50	2	5	5	NUM
ajlm-2384	50	3	(	(	PUNCT
ajlm-2384	50	4	in	in	ADP
ajlm-2384	50	5	a	a	PRON
ajlm-2384	50	6	)	)	PUNCT
ajlm-2384	50	7	and	and	CCONJ
ajlm-2384	50	8	lane	lane	NOUN
ajlm-2384	50	9	3	3	NUM
ajlm-2384	50	10	(	(	PUNCT
ajlm-2384	50	11	in	in	ADP
ajlm-2384	50	12	b	b	NOUN
ajlm-2384	50	13	)	)	PUNCT
ajlm-2384	50	14	are	be	AUX
ajlm-2384	50	15	known	know	VERB
ajlm-2384	50	16	positive	positive	ADJ
ajlm-2384	50	17	controls	control	NOUN
ajlm-2384	50	18	.	.	PUNCT
ajlm-2384	51	1	lane	lane	NOUN
ajlm-2384	51	2	6	6	NUM
ajlm-2384	51	3	(	(	PUNCT
ajlm-2384	51	4	in	in	ADP
ajlm-2384	51	5	a	a	PRON
ajlm-2384	51	6	)	)	PUNCT
ajlm-2384	51	7	and	and	CCONJ
ajlm-2384	51	8	lane	lane	NOUN
ajlm-2384	51	9	4	4	NUM
ajlm-2384	51	10	(	(	PUNCT
ajlm-2384	51	11	in	in	ADP
ajlm-2384	51	12	b	b	NOUN
ajlm-2384	51	13	)	)	PUNCT
ajlm-2384	51	14	are	be	AUX
ajlm-2384	51	15	known	know	VERB
ajlm-2384	51	16	negative	negative	ADJ
ajlm-2384	51	17	controls	control	NOUN
ajlm-2384	51	18	.	.	PUNCT
ajlm-2384	52	1	lane	lane	NOUN
ajlm-2384	52	2	7	7	NUM
ajlm-2384	52	3	is	be	AUX
ajlm-2384	52	4	the	the	DET
ajlm-2384	52	5	no	no	DET
ajlm-2384	52	6	-	-	PUNCT
ajlm-2384	52	7	template	template	NOUN
ajlm-2384	52	8	control	control	NOUN
ajlm-2384	52	9	in	in	ADP
ajlm-2384	52	10	image	image	NOUN
ajlm-2384	52	11	a	a	PRON
ajlm-2384	52	12	and	and	CCONJ
ajlm-2384	52	13	lane	lane	NOUN
ajlm-2384	52	14	5	5	NUM
ajlm-2384	52	15	is	be	AUX
ajlm-2384	52	16	the	the	DET
ajlm-2384	52	17	no	no	DET
ajlm-2384	52	18	-	-	PUNCT
ajlm-2384	52	19	template	template	NOUN
ajlm-2384	52	20	control	control	NOUN
ajlm-2384	52	21	in	in	ADP
ajlm-2384	52	22	image	image	PROPN
ajlm-2384	52	23	b.	b.	PROPN
ajlm-2384	52	24	lanes	lanes	PROPN
ajlm-2384	52	25	l	l	X
ajlm-2384	52	26	in	in	ADP
ajlm-2384	52	27	both	both	DET
ajlm-2384	52	28	images	image	NOUN
ajlm-2384	52	29	contain	contain	VERB
ajlm-2384	52	30	generuler	generuler	NOUN
ajlm-2384	52	31	dna	dna	NOUN
ajlm-2384	52	32	ladder	ladder	NOUN
ajlm-2384	52	33	mix	mix	NOUN
ajlm-2384	52	34	(	(	PUNCT
ajlm-2384	52	35	thermo	thermo	NOUN
ajlm-2384	52	36	scientific	scientific	NOUN
ajlm-2384	52	37	)	)	PUNCT
ajlm-2384	52	38	used	use	VERB
ajlm-2384	52	39	as	as	ADP
ajlm-2384	52	40	a	a	DET
ajlm-2384	52	41	reference	reference	NOUN
ajlm-2384	52	42	to	to	PART
ajlm-2384	52	43	estimate	estimate	VERB
ajlm-2384	52	44	the	the	DET
ajlm-2384	52	45	size	size	NOUN
ajlm-2384	52	46	of	of	ADP
ajlm-2384	52	47	the	the	DET
ajlm-2384	52	48	unknown	unknown	ADJ
ajlm-2384	52	49	fragment	fragment	NOUN
ajlm-2384	52	50	.	.	PUNCT
ajlm-2384	53	1	the	the	DET
ajlm-2384	53	2	family	family	NOUN
ajlm-2384	53	3	pedigree	pedigree	NOUN
ajlm-2384	53	4	(	(	PUNCT
ajlm-2384	53	5	figure	figure	NOUN
ajlm-2384	53	6	2	2	NUM
ajlm-2384	53	7	)	)	PUNCT
ajlm-2384	53	8	and	and	CCONJ
ajlm-2384	53	9	characteristics	characteristic	NOUN
ajlm-2384	53	10	(	(	PUNCT
ajlm-2384	53	11	table	table	NOUN
ajlm-2384	53	12	2	2	NUM
ajlm-2384	53	13	)	)	PUNCT
ajlm-2384	53	14	indicated	indicate	VERB
ajlm-2384	53	15	variable	variable	ADJ
ajlm-2384	53	16	presentations	presentation	NOUN
ajlm-2384	53	17	across	across	ADP
ajlm-2384	53	18	three	three	NUM
ajlm-2384	53	19	generations	generation	NOUN
ajlm-2384	53	20	.	.	PUNCT
ajlm-2384	54	1	the	the	DET
ajlm-2384	54	2	proband	proband	NOUN
ajlm-2384	54	3	’s	’s	PART
ajlm-2384	54	4	mother	mother	NOUN
ajlm-2384	54	5	had	have	AUX
ajlm-2384	54	6	hearing	hear	VERB
ajlm-2384	54	7	difficulties	difficulty	NOUN
ajlm-2384	54	8	and	and	CCONJ
ajlm-2384	54	9	died	die	VERB
ajlm-2384	54	10	from	from	ADP
ajlm-2384	54	11	a	a	DET
ajlm-2384	54	12	suspected	suspect	VERB
ajlm-2384	54	13	cardiovascular	cardiovascular	ADJ
ajlm-2384	54	14	cause	cause	NOUN
ajlm-2384	54	15	at	at	ADP
ajlm-2384	54	16	age	age	NOUN
ajlm-2384	54	17	43	43	NUM
ajlm-2384	54	18	years	year	NOUN
ajlm-2384	54	19	.	.	PUNCT
ajlm-2384	55	1	among	among	ADP
ajlm-2384	55	2	his	his	PRON
ajlm-2384	55	3	three	three	NUM
ajlm-2384	55	4	sisters	sister	NOUN
ajlm-2384	55	5	,	,	PUNCT
ajlm-2384	55	6	two	two	NUM
ajlm-2384	55	7	were	be	AUX
ajlm-2384	55	8	diagnosed	diagnose	VERB
ajlm-2384	55	9	with	with	ADP
ajlm-2384	55	10	diabetes	diabetes	NOUN
ajlm-2384	55	11	and	and	CCONJ
ajlm-2384	55	12	deafness	deafness	NOUN
ajlm-2384	55	13	,	,	PUNCT
ajlm-2384	55	14	and	and	CCONJ
ajlm-2384	55	15	died	die	VERB
ajlm-2384	55	16	prematurely	prematurely	ADV
ajlm-2384	55	17	,	,	PUNCT
ajlm-2384	55	18	one	one	NUM
ajlm-2384	55	19	at	at	ADP
ajlm-2384	55	20	age	age	NOUN
ajlm-2384	55	21	46	46	NUM
ajlm-2384	55	22	(	(	PUNCT
ajlm-2384	55	23	ii	ii	NOUN
ajlm-2384	55	24	5	5	NUM
ajlm-2384	55	25	)	)	PUNCT
ajlm-2384	55	26	due	due	ADP
ajlm-2384	55	27	to	to	ADP
ajlm-2384	55	28	congestive	congestive	VERB
ajlm-2384	55	29	cardiac	cardiac	ADJ
ajlm-2384	55	30	failure	failure	NOUN
ajlm-2384	55	31	,	,	PUNCT
ajlm-2384	55	32	and	and	CCONJ
ajlm-2384	55	33	the	the	DET
ajlm-2384	55	34	other	other	ADJ
ajlm-2384	55	35	at	at	ADP
ajlm-2384	55	36	54	54	NUM
ajlm-2384	55	37	years	year	NOUN
ajlm-2384	55	38	(	(	PUNCT
ajlm-2384	55	39	ii	ii	NOUN
ajlm-2384	55	40	6	6	NUM
ajlm-2384	55	41	)	)	PUNCT
ajlm-2384	55	42	due	due	ADP
ajlm-2384	55	43	to	to	ADP
ajlm-2384	55	44	acute	acute	VERB
ajlm-2384	55	45	myocardial	myocardial	ADJ
ajlm-2384	55	46	infarction	infarction	NOUN
ajlm-2384	55	47	.	.	PUNCT
ajlm-2384	56	1	a	a	DET
ajlm-2384	56	2	son	son	NOUN
ajlm-2384	56	3	of	of	ADP
ajlm-2384	56	4	one	one	NUM
ajlm-2384	56	5	of	of	ADP
ajlm-2384	56	6	these	these	DET
ajlm-2384	56	7	sisters	sister	NOUN
ajlm-2384	56	8	(	(	PUNCT
ajlm-2384	56	9	iii	iii	NOUN
ajlm-2384	56	10	7	7	NUM
ajlm-2384	56	11	)	)	PUNCT
ajlm-2384	56	12	was	be	AUX
ajlm-2384	56	13	diagnosed	diagnose	VERB
ajlm-2384	56	14	with	with	ADP
ajlm-2384	56	15	diabetes	diabetes	NOUN
ajlm-2384	56	16	(	(	PUNCT
ajlm-2384	56	17	hba1c	hba1c	NOUN
ajlm-2384	56	18	=	=	SYM
ajlm-2384	56	19	7.7	7.7	NUM
ajlm-2384	56	20	%	%	NOUN
ajlm-2384	56	21	)	)	PUNCT
ajlm-2384	56	22	,	,	PUNCT
ajlm-2384	56	23	hearing	hear	VERB
ajlm-2384	56	24	loss	loss	NOUN
ajlm-2384	56	25	and	and	CCONJ
ajlm-2384	56	26	had	have	VERB
ajlm-2384	56	27	the	the	DET
ajlm-2384	56	28	m.3243a	m.3243a	NOUN
ajlm-2384	56	29	>	>	NOUN
ajlm-2384	56	30	g	g	NOUN
ajlm-2384	56	31	variant	variant	NOUN
ajlm-2384	56	32	.	.	PUNCT
ajlm-2384	57	1	the	the	DET
ajlm-2384	57	2	third	third	ADJ
ajlm-2384	57	3	sister	sister	NOUN
ajlm-2384	57	4	(	(	PUNCT
ajlm-2384	57	5	ii	ii	NOUN
ajlm-2384	57	6	4	4	NUM
ajlm-2384	57	7	)	)	PUNCT
ajlm-2384	57	8	also	also	ADV
ajlm-2384	57	9	tested	test	VERB
ajlm-2384	57	10	positive	positive	ADJ
ajlm-2384	57	11	for	for	ADP
ajlm-2384	57	12	the	the	DET
ajlm-2384	57	13	m.3243a	m.3243a	ADJ
ajlm-2384	57	14	>	>	NOUN
ajlm-2384	57	15	g	g	NOUN
ajlm-2384	57	16	variant	variant	NOUN
ajlm-2384	57	17	;	;	PUNCT
ajlm-2384	57	18	however	however	ADV
ajlm-2384	57	19	,	,	PUNCT
ajlm-2384	57	20	apart	apart	ADV
ajlm-2384	57	21	from	from	ADP
ajlm-2384	57	22	a	a	DET
ajlm-2384	57	23	recent	recent	ADJ
ajlm-2384	57	24	decline	decline	NOUN
ajlm-2384	57	25	in	in	ADP
ajlm-2384	57	26	hearing	hearing	NOUN
ajlm-2384	57	27	,	,	PUNCT
ajlm-2384	57	28	she	she	PRON
ajlm-2384	57	29	had	have	VERB
ajlm-2384	57	30	no	no	DET
ajlm-2384	57	31	features	feature	NOUN
ajlm-2384	57	32	of	of	ADP
ajlm-2384	57	33	target	target	NOUN
ajlm-2384	57	34	organ	organ	NOUN
ajlm-2384	57	35	damage	damage	NOUN
ajlm-2384	57	36	.	.	PUNCT
ajlm-2384	58	1	in	in	ADP
ajlm-2384	58	2	contrast	contrast	NOUN
ajlm-2384	58	3	,	,	PUNCT
ajlm-2384	58	4	her	her	PRON
ajlm-2384	58	5	daughter	daughter	NOUN
ajlm-2384	58	6	(	(	PUNCT
ajlm-2384	58	7	iii	iii	PROPN
ajlm-2384	58	8	3	3	NUM
ajlm-2384	58	9	)	)	PUNCT
ajlm-2384	58	10	developed	develop	VERB
ajlm-2384	58	11	end	end	NOUN
ajlm-2384	58	12	-	-	PUNCT
ajlm-2384	58	13	stage	stage	NOUN
ajlm-2384	58	14	kidney	kidney	NOUN
ajlm-2384	58	15	failure	failure	NOUN
ajlm-2384	58	16	requiring	require	VERB
ajlm-2384	58	17	transplant	transplant	NOUN
ajlm-2384	58	18	in	in	ADP
ajlm-2384	58	19	her	her	PRON
ajlm-2384	58	20	20s	20	NOUN
ajlm-2384	58	21	.	.	PUNCT
ajlm-2384	59	1	her	her	PRON
ajlm-2384	59	2	other	other	ADJ
ajlm-2384	59	3	child	child	NOUN
ajlm-2384	59	4	,	,	PUNCT
ajlm-2384	59	5	a	a	DET
ajlm-2384	59	6	son	son	NOUN
ajlm-2384	59	7	(	(	PUNCT
ajlm-2384	59	8	iii	iii	PROPN
ajlm-2384	59	9	4	4	NUM
ajlm-2384	59	10	)	)	PUNCT
ajlm-2384	59	11	,	,	PUNCT
ajlm-2384	59	12	tested	test	VERB
ajlm-2384	59	13	negative	negative	ADJ
ajlm-2384	59	14	for	for	ADP
ajlm-2384	59	15	the	the	DET
ajlm-2384	59	16	m.3243a	m.3243a	ADJ
ajlm-2384	59	17	>	>	NOUN
ajlm-2384	59	18	g	g	NOUN
ajlm-2384	59	19	variant	variant	NOUN
ajlm-2384	59	20	and	and	CCONJ
ajlm-2384	59	21	has	have	AUX
ajlm-2384	59	22	remained	remain	VERB
ajlm-2384	59	23	free	free	ADJ
ajlm-2384	59	24	of	of	ADP
ajlm-2384	59	25	any	any	DET
ajlm-2384	59	26	related	related	ADJ
ajlm-2384	59	27	symptoms	symptom	NOUN
ajlm-2384	59	28	.	.	PUNCT
ajlm-2384	60	1	heteroplasmy	heteroplasmy	PROPN
ajlm-2384	60	2	levels	level	NOUN
ajlm-2384	60	3	were	be	AUX
ajlm-2384	60	4	not	not	PART
ajlm-2384	60	5	determined	determine	VERB
ajlm-2384	60	6	for	for	ADP
ajlm-2384	60	7	any	any	PRON
ajlm-2384	60	8	of	of	ADP
ajlm-2384	60	9	these	these	DET
ajlm-2384	60	10	cases	case	NOUN
ajlm-2384	60	11	.	.	PUNCT
ajlm-2384	61	1	figure	figure	NOUN
ajlm-2384	61	2	2	2	NUM
ajlm-2384	61	3	:	:	PUNCT
ajlm-2384	61	4	pedigree	pedigree	NOUN
ajlm-2384	61	5	of	of	ADP
ajlm-2384	61	6	proband	proband	PROPN
ajlm-2384	61	7	’s	’s	PART
ajlm-2384	61	8	family	family	NOUN
ajlm-2384	61	9	with	with	ADP
ajlm-2384	61	10	maternally	maternally	ADV
ajlm-2384	61	11	inherited	inherit	VERB
ajlm-2384	61	12	diabetes	diabetes	NOUN
ajlm-2384	61	13	and	and	CCONJ
ajlm-2384	61	14	deafness	deafness	NOUN
ajlm-2384	61	15	showing	show	VERB
ajlm-2384	61	16	variable	variable	ADJ
ajlm-2384	61	17	presentation	presentation	NOUN
ajlm-2384	61	18	across	across	ADP
ajlm-2384	61	19	three	three	NUM
ajlm-2384	61	20	generations	generation	NOUN
ajlm-2384	61	21	in	in	ADP
ajlm-2384	61	22	south	south	PROPN
ajlm-2384	61	23	africa	africa	PROPN
ajlm-2384	61	24	,	,	PUNCT
ajlm-2384	61	25	2016	2016	NUM
ajlm-2384	61	26	.	.	PUNCT
ajlm-2384	62	1	while	while	SCONJ
ajlm-2384	62	2	one	one	NUM
ajlm-2384	62	3	of	of	ADP
ajlm-2384	62	4	the	the	DET
ajlm-2384	62	5	family	family	NOUN
ajlm-2384	62	6	members	member	NOUN
ajlm-2384	62	7	(	(	PUNCT
ajlm-2384	62	8	ii	ii	NOUN
ajlm-2384	62	9	4	4	NUM
ajlm-2384	62	10	)	)	PUNCT
ajlm-2384	62	11	only	only	ADV
ajlm-2384	62	12	developed	develop	VERB
ajlm-2384	62	13	mild	mild	ADJ
ajlm-2384	62	14	disease	disease	NOUN
ajlm-2384	62	15	later	later	ADV
ajlm-2384	62	16	in	in	ADP
ajlm-2384	62	17	life	life	NOUN
ajlm-2384	62	18	,	,	PUNCT
ajlm-2384	62	19	another	another	PRON
ajlm-2384	62	20	(	(	PUNCT
ajlm-2384	62	21	iii	iii	NOUN
ajlm-2384	62	22	7	7	NUM
ajlm-2384	62	23	)	)	PUNCT
ajlm-2384	62	24	presented	present	VERB
ajlm-2384	62	25	with	with	ADP
ajlm-2384	62	26	severe	severe	ADJ
ajlm-2384	62	27	disease	disease	NOUN
ajlm-2384	62	28	early	early	ADV
ajlm-2384	62	29	in	in	ADP
ajlm-2384	62	30	life	life	NOUN
ajlm-2384	62	31	.	.	PUNCT
ajlm-2384	63	1	the	the	DET
ajlm-2384	63	2	proband	proband	NOUN
ajlm-2384	63	3	’s	’s	PART
ajlm-2384	63	4	mother	mother	NOUN
ajlm-2384	63	5	(	(	PUNCT
ajlm-2384	63	6	i	i	NOUN
ajlm-2384	63	7	2	2	NUM
ajlm-2384	63	8	)	)	PUNCT
ajlm-2384	63	9	and	and	CCONJ
ajlm-2384	63	10	two	two	NUM
ajlm-2384	63	11	of	of	ADP
ajlm-2384	63	12	his	his	PRON
ajlm-2384	63	13	sisters	sister	NOUN
ajlm-2384	63	14	(	(	PUNCT
ajlm-2384	63	15	ii	ii	PROPN
ajlm-2384	63	16	5	5	NUM
ajlm-2384	63	17	and	and	CCONJ
ajlm-2384	63	18	ii	ii	NUM
ajlm-2384	63	19	6	6	NUM
ajlm-2384	63	20	)	)	PUNCT
ajlm-2384	63	21	had	have	AUX
ajlm-2384	63	22	hearing	hear	VERB
ajlm-2384	63	23	loss	loss	NOUN
ajlm-2384	63	24	and	and	CCONJ
ajlm-2384	63	25	all	all	PRON
ajlm-2384	63	26	died	die	VERB
ajlm-2384	63	27	of	of	ADP
ajlm-2384	63	28	cardiovascular	cardiovascular	ADJ
ajlm-2384	63	29	related	relate	VERB
ajlm-2384	63	30	diseases	disease	NOUN
ajlm-2384	63	31	.	.	PUNCT
ajlm-2384	64	1	table	table	NOUN
ajlm-2384	64	2	2	2	NUM
ajlm-2384	64	3	:	:	PUNCT
ajlm-2384	64	4	 	 	SPACE
ajlm-2384	64	5	clinical	clinical	ADJ
ajlm-2384	64	6	and	and	CCONJ
ajlm-2384	64	7	laboratory	laboratory	NOUN
ajlm-2384	64	8	features	feature	NOUN
ajlm-2384	64	9	of	of	ADP
ajlm-2384	64	10	proband	proband	NOUN
ajlm-2384	64	11	with	with	ADP
ajlm-2384	64	12	maternally	maternally	ADV
ajlm-2384	64	13	inherited	inherit	VERB
ajlm-2384	64	14	diabetes	diabetes	NOUN
ajlm-2384	64	15	and	and	CCONJ
ajlm-2384	64	16	deafness	deafness	NOUN
ajlm-2384	64	17	and	and	CCONJ
ajlm-2384	64	18	available	available	ADJ
ajlm-2384	64	19	maternal	maternal	ADJ
ajlm-2384	64	20	relatives	relative	NOUN
ajlm-2384	64	21	obtained	obtain	VERB
ajlm-2384	64	22	in	in	ADP
ajlm-2384	64	23	2015	2015	NUM
ajlm-2384	64	24	and	and	CCONJ
ajlm-2384	64	25	2016	2016	NUM
ajlm-2384	64	26	,	,	PUNCT
ajlm-2384	64	27	south	south	PROPN
ajlm-2384	64	28	africa	africa	PROPN
ajlm-2384	64	29	.	.	PUNCT
ajlm-2384	65	1	management	management	NOUN
ajlm-2384	65	2	and	and	CCONJ
ajlm-2384	65	3	outcome	outcome	VERB
ajlm-2384	65	4	a	a	DET
ajlm-2384	65	5	multidisciplinary	multidisciplinary	ADJ
ajlm-2384	65	6	team	team	NOUN
ajlm-2384	65	7	was	be	AUX
ajlm-2384	65	8	involved	involve	VERB
ajlm-2384	65	9	in	in	ADP
ajlm-2384	65	10	the	the	DET
ajlm-2384	65	11	management	management	NOUN
ajlm-2384	65	12	of	of	ADP
ajlm-2384	65	13	the	the	DET
ajlm-2384	65	14	patients	patient	NOUN
ajlm-2384	65	15	discussed	discuss	VERB
ajlm-2384	65	16	in	in	ADP
ajlm-2384	65	17	this	this	DET
ajlm-2384	65	18	study	study	NOUN
ajlm-2384	65	19	.	.	PUNCT
ajlm-2384	66	1	insulin	insulin	NOUN
ajlm-2384	66	2	secretagogues	secretagogue	NOUN
ajlm-2384	66	3	were	be	AUX
ajlm-2384	66	4	considered	consider	VERB
ajlm-2384	66	5	for	for	ADP
ajlm-2384	66	6	the	the	DET
ajlm-2384	66	7	treatment	treatment	NOUN
ajlm-2384	66	8	of	of	ADP
ajlm-2384	66	9	diabetes	diabetes	NOUN
ajlm-2384	66	10	.	.	PUNCT
ajlm-2384	67	1	the	the	DET
ajlm-2384	67	2	proband	proband	NOUN
ajlm-2384	67	3	had	have	VERB
ajlm-2384	67	4	severe	severe	ADJ
ajlm-2384	67	5	myopathy	myopathy	ADJ
ajlm-2384	67	6	requiring	require	VERB
ajlm-2384	67	7	a	a	DET
ajlm-2384	67	8	wheelchair	wheelchair	NOUN
ajlm-2384	67	9	.	.	PUNCT
ajlm-2384	68	1	the	the	DET
ajlm-2384	68	2	patient	patient	NOUN
ajlm-2384	68	3	was	be	AUX
ajlm-2384	68	4	mostly	mostly	ADV
ajlm-2384	68	5	managed	manage	VERB
ajlm-2384	68	6	in	in	ADP
ajlm-2384	68	7	primary	primary	ADJ
ajlm-2384	68	8	care	care	NOUN
ajlm-2384	68	9	,	,	PUNCT
ajlm-2384	68	10	and	and	CCONJ
ajlm-2384	68	11	was	be	AUX
ajlm-2384	68	12	referred	refer	VERB
ajlm-2384	68	13	very	very	ADV
ajlm-2384	68	14	late	late	ADV
ajlm-2384	68	15	to	to	ADP
ajlm-2384	68	16	a	a	DET
ajlm-2384	68	17	specialist	specialist	NOUN
ajlm-2384	68	18	when	when	SCONJ
ajlm-2384	68	19	he	he	PRON
ajlm-2384	68	20	had	have	AUX
ajlm-2384	68	21	already	already	ADV
ajlm-2384	68	22	developed	develop	VERB
ajlm-2384	68	23	severe	severe	ADJ
ajlm-2384	68	24	complications	complication	NOUN
ajlm-2384	68	25	,	,	PUNCT
ajlm-2384	68	26	including	include	VERB
ajlm-2384	68	27	cardiovascular	cardiovascular	ADJ
ajlm-2384	68	28	issues	issue	NOUN
ajlm-2384	68	29	.	.	PUNCT
ajlm-2384	69	1	he	he	PRON
ajlm-2384	69	2	sustained	sustain	VERB
ajlm-2384	69	3	a	a	DET
ajlm-2384	69	4	femur	femur	ADJ
ajlm-2384	69	5	fracture	fracture	NOUN
ajlm-2384	69	6	with	with	ADP
ajlm-2384	69	7	presumptive	presumptive	ADJ
ajlm-2384	69	8	pulmonary	pulmonary	ADJ
ajlm-2384	69	9	embolism	embolism	NOUN
ajlm-2384	69	10	and	and	CCONJ
ajlm-2384	69	11	died	die	VERB
ajlm-2384	69	12	before	before	SCONJ
ajlm-2384	69	13	genetic	genetic	ADJ
ajlm-2384	69	14	confirmation	confirmation	NOUN
ajlm-2384	69	15	could	could	AUX
ajlm-2384	69	16	be	be	AUX
ajlm-2384	69	17	obtained	obtain	VERB
ajlm-2384	69	18	.	.	PUNCT
ajlm-2384	70	1	his	his	PRON
ajlm-2384	70	2	maternal	maternal	ADJ
ajlm-2384	70	3	relatives	relative	NOUN
ajlm-2384	70	4	were	be	AUX
ajlm-2384	70	5	offered	offer	VERB
ajlm-2384	70	6	genetic	genetic	ADJ
ajlm-2384	70	7	counselling	counselling	NOUN
ajlm-2384	70	8	and	and	CCONJ
ajlm-2384	70	9	screening	screen	VERB
ajlm-2384	70	10	for	for	ADP
ajlm-2384	70	11	diagnosis	diagnosis	NOUN
ajlm-2384	70	12	and	and	CCONJ
ajlm-2384	70	13	management	management	NOUN
ajlm-2384	70	14	of	of	ADP
ajlm-2384	70	15	complications	complication	NOUN
ajlm-2384	70	16	.	.	PUNCT
ajlm-2384	71	1	discussion	discussion	NOUN
ajlm-2384	71	2	the	the	DET
ajlm-2384	71	3	pathogenic	pathogenic	ADJ
ajlm-2384	71	4	variant	variant	NOUN
ajlm-2384	71	5	m.3243a	m.3243a	NOUN
ajlm-2384	71	6	>	>	X
ajlm-2384	71	7	g	g	NOUN
ajlm-2384	71	8	of	of	ADP
ajlm-2384	71	9	the	the	DET
ajlm-2384	71	10	mt	mt	PROPN
ajlm-2384	71	11	-	-	PUNCT
ajlm-2384	71	12	tl1	tl1	ADJ
ajlm-2384	71	13	gene	gene	NOUN
ajlm-2384	71	14	is	be	AUX
ajlm-2384	71	15	one	one	NUM
ajlm-2384	71	16	of	of	ADP
ajlm-2384	71	17	the	the	DET
ajlm-2384	71	18	identified	identify	VERB
ajlm-2384	71	19	causes	cause	NOUN
ajlm-2384	71	20	of	of	ADP
ajlm-2384	71	21	mtdna	mtdna	ADV
ajlm-2384	71	22	-	-	PUNCT
ajlm-2384	71	23	related	relate	VERB
ajlm-2384	71	24	primary	primary	ADJ
ajlm-2384	71	25	mitochondrial	mitochondrial	ADJ
ajlm-2384	71	26	disease	disease	NOUN
ajlm-2384	71	27	worldwide	worldwide	ADV
ajlm-2384	71	28	.	.	PUNCT
ajlm-2384	72	1	it	it	PRON
ajlm-2384	72	2	was	be	AUX
ajlm-2384	72	3	initially	initially	ADV
ajlm-2384	72	4	identified	identify	VERB
ajlm-2384	72	5	in	in	ADP
ajlm-2384	72	6	patients	patient	NOUN
ajlm-2384	72	7	with	with	ADP
ajlm-2384	72	8	mitochondrial	mitochondrial	ADJ
ajlm-2384	72	9	encephalopathy	encephalopathy	NOUN
ajlm-2384	72	10	,	,	PUNCT
ajlm-2384	72	11	lactic	lactic	ADJ
ajlm-2384	72	12	acidosis	acidosis	NOUN
ajlm-2384	72	13	and	and	CCONJ
ajlm-2384	72	14	stroke	stroke	NOUN
ajlm-2384	72	15	-	-	PUNCT
ajlm-2384	72	16	like	like	ADJ
ajlm-2384	72	17	episodes	episode	NOUN
ajlm-2384	72	18	in	in	ADP
ajlm-2384	72	19	1990	1990	NUM
ajlm-2384	72	20	and	and	CCONJ
ajlm-2384	72	21	a	a	DET
ajlm-2384	72	22	couple	couple	NOUN
ajlm-2384	72	23	of	of	ADP
ajlm-2384	72	24	years	year	NOUN
ajlm-2384	72	25	later	later	ADV
ajlm-2384	72	26	in	in	ADP
ajlm-2384	72	27	a	a	DET
ajlm-2384	72	28	large	large	ADJ
ajlm-2384	72	29	pedigree	pedigree	NOUN
ajlm-2384	72	30	with	with	ADP
ajlm-2384	72	31	maternally	maternally	ADV
ajlm-2384	72	32	transmitted	transmit	VERB
ajlm-2384	72	33	diabetes	diabetes	NOUN
ajlm-2384	72	34	mellitus	mellitus	NOUN
ajlm-2384	72	35	and	and	CCONJ
ajlm-2384	72	36	deafness.12	deafness.12	VERB
ajlm-2384	72	37	the	the	DET
ajlm-2384	72	38	exact	exact	ADJ
ajlm-2384	72	39	mechanism	mechanism	NOUN
ajlm-2384	72	40	by	by	ADP
ajlm-2384	72	41	which	which	PRON
ajlm-2384	72	42	the	the	DET
ajlm-2384	72	43	m.3243a	m.3243a	NOUN
ajlm-2384	72	44	>	>	NOUN
ajlm-2384	72	45	g	g	NOUN
ajlm-2384	72	46	variant	variant	NOUN
ajlm-2384	72	47	causes	cause	NOUN
ajlm-2384	72	48	disease	disease	NOUN
ajlm-2384	72	49	is	be	AUX
ajlm-2384	72	50	still	still	ADV
ajlm-2384	72	51	incompletely	incompletely	ADV
ajlm-2384	72	52	understood	understand	VERB
ajlm-2384	72	53	.	.	PUNCT
ajlm-2384	73	1	however	however	ADV
ajlm-2384	73	2	,	,	PUNCT
ajlm-2384	73	3	decreases	decrease	NOUN
ajlm-2384	73	4	of	of	ADP
ajlm-2384	73	5	pancreatic	pancreatic	ADJ
ajlm-2384	73	6	beta	beta	NOUN
ajlm-2384	73	7	cell	cell	NOUN
ajlm-2384	73	8	mass	mass	NOUN
ajlm-2384	73	9	and	and	CCONJ
ajlm-2384	73	10	declines	decline	NOUN
ajlm-2384	73	11	in	in	ADP
ajlm-2384	73	12	glucose	glucose	NOUN
ajlm-2384	73	13	-	-	PUNCT
ajlm-2384	73	14	stimulated	stimulate	VERB
ajlm-2384	73	15	insulin	insulin	NOUN
ajlm-2384	73	16	secretion	secretion	NOUN
ajlm-2384	73	17	have	have	AUX
ajlm-2384	73	18	been	be	AUX
ajlm-2384	73	19	implicated	implicate	VERB
ajlm-2384	73	20	in	in	ADP
ajlm-2384	73	21	the	the	DET
ajlm-2384	73	22	development	development	NOUN
ajlm-2384	73	23	of	of	ADP
ajlm-2384	73	24	diabetes	diabetes	NOUN
ajlm-2384	73	25	in	in	ADP
ajlm-2384	73	26	affected	affected	ADJ
ajlm-2384	73	27	patients.13	patients.13	NOUN
ajlm-2384	73	28	maternally	maternally	ADV
ajlm-2384	73	29	inherited	inherit	VERB
ajlm-2384	73	30	diabetes	diabetes	NOUN
ajlm-2384	73	31	and	and	CCONJ
ajlm-2384	73	32	deafness	deafness	NOUN
ajlm-2384	73	33	is	be	AUX
ajlm-2384	73	34	exclusively	exclusively	ADV
ajlm-2384	73	35	inherited	inherit	VERB
ajlm-2384	73	36	through	through	ADP
ajlm-2384	73	37	the	the	DET
ajlm-2384	73	38	maternal	maternal	ADJ
ajlm-2384	73	39	line	line	NOUN
ajlm-2384	73	40	,	,	PUNCT
ajlm-2384	73	41	as	as	SCONJ
ajlm-2384	73	42	the	the	DET
ajlm-2384	73	43	paternal	paternal	ADJ
ajlm-2384	73	44	contribution	contribution	NOUN
ajlm-2384	73	45	of	of	ADP
ajlm-2384	73	46	sperm	sperm	NOUN
ajlm-2384	73	47	mitochondria	mitochondria	NOUN
ajlm-2384	73	48	to	to	ADP
ajlm-2384	73	49	the	the	DET
ajlm-2384	73	50	fertilised	fertilise	VERB
ajlm-2384	73	51	egg	egg	NOUN
ajlm-2384	73	52	is	be	AUX
ajlm-2384	73	53	minimal	minimal	ADJ
ajlm-2384	73	54	,	,	PUNCT
ajlm-2384	73	55	about	about	ADV
ajlm-2384	73	56	1000	1000	NUM
ajlm-2384	73	57	-	-	NUM
ajlm-2384	73	58	fold	fold	VERB
ajlm-2384	73	59	less	less	ADJ
ajlm-2384	73	60	than	than	ADP
ajlm-2384	73	61	that	that	PRON
ajlm-2384	73	62	of	of	ADP
ajlm-2384	73	63	the	the	DET
ajlm-2384	73	64	oocyte	oocyte	NOUN
ajlm-2384	73	65	,	,	PUNCT
ajlm-2384	73	66	and	and	CCONJ
ajlm-2384	73	67	there	there	PRON
ajlm-2384	73	68	are	be	VERB
ajlm-2384	73	69	selective	selective	ADJ
ajlm-2384	73	70	mechanisms	mechanism	NOUN
ajlm-2384	73	71	targeting	target	VERB
ajlm-2384	73	72	paternal	paternal	ADJ
ajlm-2384	73	73	mtdna	mtdna	NOUN
ajlm-2384	73	74	for	for	ADP
ajlm-2384	73	75	destruction	destruction	NOUN
ajlm-2384	73	76	,	,	PUNCT
ajlm-2384	73	77	further	far	ADV
ajlm-2384	73	78	reinforcing	reinforce	VERB
ajlm-2384	73	79	the	the	DET
ajlm-2384	73	80	maternal	maternal	ADJ
ajlm-2384	73	81	inheritance	inheritance	NOUN
ajlm-2384	73	82	pattern.14	pattern.14	PROPN
ajlm-2384	73	83	patients	patient	NOUN
ajlm-2384	73	84	with	with	ADP
ajlm-2384	73	85	midd	midd	NOUN
ajlm-2384	73	86	range	range	NOUN
ajlm-2384	73	87	in	in	ADP
ajlm-2384	73	88	age	age	NOUN
ajlm-2384	73	89	from	from	ADP
ajlm-2384	73	90	12	12	NUM
ajlm-2384	73	91	years	year	NOUN
ajlm-2384	73	92	to	to	ADP
ajlm-2384	73	93	67	67	NUM
ajlm-2384	73	94	years	year	NOUN
ajlm-2384	73	95	when	when	SCONJ
ajlm-2384	73	96	they	they	PRON
ajlm-2384	73	97	present	present	VERB
ajlm-2384	73	98	with	with	ADP
ajlm-2384	73	99	diabetes	diabetes	NOUN
ajlm-2384	73	100	,	,	PUNCT
ajlm-2384	73	101	and	and	CCONJ
ajlm-2384	73	102	diabetes	diabetes	NOUN
ajlm-2384	73	103	is	be	AUX
ajlm-2384	73	104	often	often	ADV
ajlm-2384	73	105	the	the	DET
ajlm-2384	73	106	presenting	presenting	NOUN
ajlm-2384	73	107	problem	problem	NOUN
ajlm-2384	73	108	,	,	PUNCT
ajlm-2384	73	109	although	although	SCONJ
ajlm-2384	73	110	in	in	ADP
ajlm-2384	73	111	some	some	DET
ajlm-2384	73	112	patients	patient	NOUN
ajlm-2384	73	113	,	,	PUNCT
ajlm-2384	73	114	onset	onset	NOUN
ajlm-2384	73	115	of	of	ADP
ajlm-2384	73	116	sensorineural	sensorineural	ADJ
ajlm-2384	73	117	deafness	deafness	NOUN
ajlm-2384	73	118	may	may	AUX
ajlm-2384	73	119	precede	precede	VERB
ajlm-2384	73	120	presentation	presentation	NOUN
ajlm-2384	73	121	of	of	ADP
ajlm-2384	73	122	diabetes.13	diabetes.13	NOUN
ajlm-2384	73	123	a	a	DET
ajlm-2384	73	124	definitive	definitive	ADJ
ajlm-2384	73	125	diagnosis	diagnosis	NOUN
ajlm-2384	73	126	is	be	AUX
ajlm-2384	73	127	only	only	ADV
ajlm-2384	73	128	possible	possible	ADJ
ajlm-2384	73	129	through	through	ADP
ajlm-2384	73	130	genetic	genetic	ADJ
ajlm-2384	73	131	confirmation	confirmation	NOUN
ajlm-2384	73	132	.	.	PUNCT
ajlm-2384	74	1	screening	screen	VERB
ajlm-2384	74	2	for	for	SCONJ
ajlm-2384	74	3	the	the	DET
ajlm-2384	74	4	common	common	ADJ
ajlm-2384	74	5	m.3243a	m.3243a	NOUN
ajlm-2384	74	6	>	>	NOUN
ajlm-2384	74	7	g	g	ADJ
ajlm-2384	74	8	variant	variant	NOUN
ajlm-2384	74	9	is	be	AUX
ajlm-2384	74	10	best	well	ADV
ajlm-2384	74	11	performed	perform	VERB
ajlm-2384	74	12	using	use	VERB
ajlm-2384	74	13	dna	dna	PROPN
ajlm-2384	74	14	from	from	ADP
ajlm-2384	74	15	epithelial	epithelial	ADJ
ajlm-2384	74	16	cells	cell	NOUN
ajlm-2384	74	17	in	in	ADP
ajlm-2384	74	18	urine	urine	NOUN
ajlm-2384	74	19	or	or	CCONJ
ajlm-2384	74	20	muscle	muscle	NOUN
ajlm-2384	74	21	,	,	PUNCT
ajlm-2384	74	22	as	as	SCONJ
ajlm-2384	74	23	heteroplasmy	heteroplasmy	PROPN
ajlm-2384	74	24	levels	level	NOUN
ajlm-2384	74	25	tend	tend	VERB
ajlm-2384	74	26	to	to	PART
ajlm-2384	74	27	decrease	decrease	VERB
ajlm-2384	74	28	with	with	ADP
ajlm-2384	74	29	age	age	NOUN
ajlm-2384	74	30	in	in	ADP
ajlm-2384	74	31	actively	actively	ADV
ajlm-2384	74	32	dividing	divide	VERB
ajlm-2384	74	33	cells	cell	NOUN
ajlm-2384	74	34	in	in	ADP
ajlm-2384	74	35	blood.15	blood.15	NOUN
ajlm-2384	74	36	in	in	ADP
ajlm-2384	74	37	the	the	DET
ajlm-2384	74	38	case	case	NOUN
ajlm-2384	74	39	of	of	ADP
ajlm-2384	74	40	the	the	DET
ajlm-2384	74	41	proband	proband	NOUN
ajlm-2384	74	42	,	,	PUNCT
ajlm-2384	74	43	the	the	DET
ajlm-2384	74	44	midd	midd	NOUN
ajlm-2384	74	45	diagnosis	diagnosis	NOUN
ajlm-2384	74	46	was	be	AUX
ajlm-2384	74	47	inferred	infer	VERB
ajlm-2384	74	48	from	from	ADP
ajlm-2384	74	49	a	a	DET
ajlm-2384	74	50	combination	combination	NOUN
ajlm-2384	74	51	of	of	ADP
ajlm-2384	74	52	clinical	clinical	ADJ
ajlm-2384	74	53	and	and	CCONJ
ajlm-2384	74	54	laboratory	laboratory	NOUN
ajlm-2384	74	55	features	feature	NOUN
ajlm-2384	74	56	,	,	PUNCT
ajlm-2384	74	57	a	a	DET
ajlm-2384	74	58	strong	strong	ADJ
ajlm-2384	74	59	family	family	NOUN
ajlm-2384	74	60	history	history	NOUN
ajlm-2384	74	61	,	,	PUNCT
ajlm-2384	74	62	and	and	CCONJ
ajlm-2384	74	63	the	the	DET
ajlm-2384	74	64	positive	positive	ADJ
ajlm-2384	74	65	identification	identification	NOUN
ajlm-2384	74	66	of	of	ADP
ajlm-2384	74	67	the	the	DET
ajlm-2384	74	68	m.3243a	m.3243a	NOUN
ajlm-2384	74	69	>	>	NOUN
ajlm-2384	74	70	g	g	NOUN
ajlm-2384	74	71	variant	variant	NOUN
ajlm-2384	74	72	in	in	ADP
ajlm-2384	74	73	some	some	PRON
ajlm-2384	74	74	of	of	ADP
ajlm-2384	74	75	his	his	PRON
ajlm-2384	74	76	maternal	maternal	ADJ
ajlm-2384	74	77	relatives	relative	NOUN
ajlm-2384	74	78	.	.	PUNCT
ajlm-2384	75	1	the	the	DET
ajlm-2384	75	2	clinical	clinical	ADJ
ajlm-2384	75	3	spectrum	spectrum	NOUN
ajlm-2384	75	4	of	of	ADP
ajlm-2384	75	5	midd	midd	PROPN
ajlm-2384	75	6	exhibits	exhibit	NOUN
ajlm-2384	75	7	heterogeneity	heterogeneity	NOUN
ajlm-2384	75	8	,	,	PUNCT
ajlm-2384	75	9	encompassing	encompass	VERB
ajlm-2384	75	10	variation	variation	NOUN
ajlm-2384	75	11	in	in	ADP
ajlm-2384	75	12	terms	term	NOUN
ajlm-2384	75	13	of	of	ADP
ajlm-2384	75	14	age	age	NOUN
ajlm-2384	75	15	of	of	ADP
ajlm-2384	75	16	onset	onset	NOUN
ajlm-2384	75	17	,	,	PUNCT
ajlm-2384	75	18	clinical	clinical	ADJ
ajlm-2384	75	19	manifestation	manifestation	NOUN
ajlm-2384	75	20	and	and	CCONJ
ajlm-2384	75	21	severity.5	severity.5	PROPN
ajlm-2384	75	22	as	as	SCONJ
ajlm-2384	75	23	observed	observe	VERB
ajlm-2384	75	24	in	in	ADP
ajlm-2384	75	25	this	this	DET
ajlm-2384	75	26	study	study	NOUN
ajlm-2384	75	27	,	,	PUNCT
ajlm-2384	75	28	the	the	DET
ajlm-2384	75	29	proband	proband	NOUN
ajlm-2384	75	30	’s	’s	PART
ajlm-2384	75	31	sister	sister	NOUN
ajlm-2384	75	32	tested	test	VERB
ajlm-2384	75	33	positive	positive	ADJ
ajlm-2384	75	34	for	for	ADP
ajlm-2384	75	35	the	the	DET
ajlm-2384	75	36	m.3243a	m.3243a	NOUN
ajlm-2384	75	37	>	>	NOUN
ajlm-2384	75	38	g	g	NOUN
ajlm-2384	75	39	pathogenic	pathogenic	ADJ
ajlm-2384	75	40	variant	variant	NOUN
ajlm-2384	75	41	but	but	CCONJ
ajlm-2384	75	42	remained	remain	VERB
ajlm-2384	75	43	asymptomatic	asymptomatic	ADJ
ajlm-2384	75	44	throughout	throughout	ADP
ajlm-2384	75	45	most	most	ADJ
ajlm-2384	75	46	of	of	ADP
ajlm-2384	75	47	her	her	PRON
ajlm-2384	75	48	adult	adult	NOUN
ajlm-2384	75	49	life	life	NOUN
ajlm-2384	75	50	.	.	PUNCT
ajlm-2384	76	1	she	she	PRON
ajlm-2384	76	2	only	only	ADV
ajlm-2384	76	3	developed	develop	VERB
ajlm-2384	76	4	decreased	decrease	VERB
ajlm-2384	76	5	hearing	hear	VERB
ajlm-2384	76	6	after	after	ADP
ajlm-2384	76	7	reaching	reach	VERB
ajlm-2384	76	8	age	age	NOUN
ajlm-2384	76	9	60	60	NUM
ajlm-2384	76	10	years	year	NOUN
ajlm-2384	76	11	.	.	PUNCT
ajlm-2384	77	1	complications	complication	NOUN
ajlm-2384	77	2	in	in	ADP
ajlm-2384	77	3	patients	patient	NOUN
ajlm-2384	77	4	with	with	ADP
ajlm-2384	77	5	midd	midd	NOUN
ajlm-2384	77	6	follow	follow	VERB
ajlm-2384	77	7	a	a	DET
ajlm-2384	77	8	distinct	distinct	ADJ
ajlm-2384	77	9	pathophysiology	pathophysiology	NOUN
ajlm-2384	77	10	compared	compare	VERB
ajlm-2384	77	11	to	to	ADP
ajlm-2384	77	12	complications	complication	NOUN
ajlm-2384	77	13	in	in	ADP
ajlm-2384	77	14	patients	patient	NOUN
ajlm-2384	77	15	with	with	ADP
ajlm-2384	77	16	type	type	NOUN
ajlm-2384	77	17	1	1	NUM
ajlm-2384	77	18	and	and	CCONJ
ajlm-2384	77	19	type	type	NOUN
ajlm-2384	77	20	2	2	NUM
ajlm-2384	77	21	diabetes	diabetes	NOUN
ajlm-2384	77	22	.	.	PUNCT
ajlm-2384	78	1	proteinuria	proteinuria	PROPN
ajlm-2384	78	2	arises	arise	VERB
ajlm-2384	78	3	as	as	ADP
ajlm-2384	78	4	a	a	DET
ajlm-2384	78	5	consequence	consequence	NOUN
ajlm-2384	78	6	of	of	ADP
ajlm-2384	78	7	the	the	DET
ajlm-2384	78	8	mitochondrial	mitochondrial	NOUN
ajlm-2384	78	9	dysfunction.2,5	dysfunction.2,5	PROPN
ajlm-2384	78	10	the	the	DET
ajlm-2384	78	11	renal	renal	ADJ
ajlm-2384	78	12	impairment	impairment	NOUN
ajlm-2384	78	13	is	be	AUX
ajlm-2384	78	14	frequently	frequently	ADV
ajlm-2384	78	15	misdiagnosed	misdiagnose	VERB
ajlm-2384	78	16	as	as	ADP
ajlm-2384	78	17	diabetic	diabetic	ADJ
ajlm-2384	78	18	kidney	kidney	NOUN
ajlm-2384	78	19	disease	disease	NOUN
ajlm-2384	78	20	;	;	PUNCT
ajlm-2384	78	21	however	however	ADV
ajlm-2384	78	22	,	,	PUNCT
ajlm-2384	78	23	in	in	ADP
ajlm-2384	78	24	some	some	DET
ajlm-2384	78	25	patients	patient	NOUN
ajlm-2384	78	26	,	,	PUNCT
ajlm-2384	78	27	kidney	kidney	NOUN
ajlm-2384	78	28	failure	failure	NOUN
ajlm-2384	78	29	may	may	AUX
ajlm-2384	78	30	even	even	ADV
ajlm-2384	78	31	develop	develop	VERB
ajlm-2384	78	32	before	before	ADP
ajlm-2384	78	33	the	the	DET
ajlm-2384	78	34	onset	onset	NOUN
ajlm-2384	78	35	of	of	ADP
ajlm-2384	78	36	diabetes	diabetes	NOUN
ajlm-2384	78	37	.	.	PUNCT
ajlm-2384	79	1	as	as	SCONJ
ajlm-2384	79	2	shown	show	VERB
ajlm-2384	79	3	with	with	ADP
ajlm-2384	79	4	the	the	DET
ajlm-2384	79	5	proband	proband	NOUN
ajlm-2384	79	6	’s	’s	PART
ajlm-2384	79	7	niece	niece	NOUN
ajlm-2384	79	8	,	,	PUNCT
ajlm-2384	79	9	end	end	NOUN
ajlm-2384	79	10	-	-	PUNCT
ajlm-2384	79	11	stage	stage	NOUN
ajlm-2384	79	12	kidney	kidney	NOUN
ajlm-2384	79	13	disease	disease	NOUN
ajlm-2384	79	14	necessitating	necessitate	VERB
ajlm-2384	79	15	kidney	kidney	NOUN
ajlm-2384	79	16	transplantation	transplantation	NOUN
ajlm-2384	79	17	can	can	AUX
ajlm-2384	79	18	develop	develop	VERB
ajlm-2384	79	19	at	at	ADP
ajlm-2384	79	20	a	a	DET
ajlm-2384	79	21	young	young	ADJ
ajlm-2384	79	22	age	age	NOUN
ajlm-2384	79	23	.	.	PUNCT
ajlm-2384	80	1	pathogenic	pathogenic	ADJ
ajlm-2384	80	2	mtdna	mtdna	NOUN
ajlm-2384	80	3	variants	variant	NOUN
ajlm-2384	80	4	,	,	PUNCT
ajlm-2384	80	5	such	such	ADJ
ajlm-2384	80	6	as	as	ADP
ajlm-2384	80	7	the	the	DET
ajlm-2384	80	8	m.3243a	m.3243a	NOUN
ajlm-2384	80	9	>	>	NOUN
ajlm-2384	80	10	g	g	NOUN
ajlm-2384	80	11	variant	variant	NOUN
ajlm-2384	80	12	,	,	PUNCT
ajlm-2384	80	13	tend	tend	VERB
ajlm-2384	80	14	to	to	PART
ajlm-2384	80	15	be	be	AUX
ajlm-2384	80	16	heteroplasmic	heteroplasmic	ADJ
ajlm-2384	80	17	in	in	ADP
ajlm-2384	80	18	all	all	DET
ajlm-2384	80	19	affected	affected	ADJ
ajlm-2384	80	20	individuals	individual	NOUN
ajlm-2384	80	21	.	.	PUNCT
ajlm-2384	81	1	one	one	NUM
ajlm-2384	81	2	of	of	ADP
ajlm-2384	81	3	the	the	DET
ajlm-2384	81	4	proband	proband	NOUN
ajlm-2384	81	5	’s	’s	PART
ajlm-2384	81	6	nephews	nephew	NOUN
ajlm-2384	81	7	tested	test	VERB
ajlm-2384	81	8	negative	negative	ADJ
ajlm-2384	81	9	for	for	ADP
ajlm-2384	81	10	this	this	DET
ajlm-2384	81	11	variant	variant	NOUN
ajlm-2384	81	12	,	,	PUNCT
ajlm-2384	81	13	but	but	CCONJ
ajlm-2384	81	14	had	have	VERB
ajlm-2384	81	15	no	no	DET
ajlm-2384	81	16	features	feature	NOUN
ajlm-2384	81	17	of	of	ADP
ajlm-2384	81	18	end	end	NOUN
ajlm-2384	81	19	-	-	PUNCT
ajlm-2384	81	20	organ	organ	NOUN
ajlm-2384	81	21	damage	damage	NOUN
ajlm-2384	81	22	.	.	PUNCT
ajlm-2384	82	1	these	these	DET
ajlm-2384	82	2	diverse	diverse	ADJ
ajlm-2384	82	3	patterns	pattern	NOUN
ajlm-2384	82	4	of	of	ADP
ajlm-2384	82	5	heteroplasmy	heteroplasmy	PROPN
ajlm-2384	82	6	underscore	underscore	VERB
ajlm-2384	82	7	the	the	DET
ajlm-2384	82	8	complex	complex	ADJ
ajlm-2384	82	9	nature	nature	NOUN
ajlm-2384	82	10	of	of	ADP
ajlm-2384	82	11	mitochondrial	mitochondrial	ADJ
ajlm-2384	82	12	genetics	genetic	NOUN
ajlm-2384	82	13	and	and	CCONJ
ajlm-2384	82	14	their	their	PRON
ajlm-2384	82	15	impact	impact	NOUN
ajlm-2384	82	16	on	on	ADP
ajlm-2384	82	17	phenotypic	phenotypic	ADJ
ajlm-2384	82	18	expression	expression	NOUN
ajlm-2384	82	19	.	.	PUNCT
ajlm-2384	83	1	in	in	ADP
ajlm-2384	83	2	this	this	DET
ajlm-2384	83	3	study	study	NOUN
ajlm-2384	83	4	,	,	PUNCT
ajlm-2384	83	5	the	the	DET
ajlm-2384	83	6	pcr	pcr	NOUN
ajlm-2384	83	7	-	-	PUNCT
ajlm-2384	83	8	restriction	restriction	NOUN
ajlm-2384	83	9	fragment	fragment	NOUN
ajlm-2384	83	10	length	length	NOUN
ajlm-2384	83	11	polymorphism	polymorphism	NOUN
ajlm-2384	83	12	method	method	NOUN
ajlm-2384	83	13	employed	employ	VERB
ajlm-2384	83	14	is	be	AUX
ajlm-2384	83	15	still	still	ADV
ajlm-2384	83	16	used	use	VERB
ajlm-2384	83	17	in	in	ADP
ajlm-2384	83	18	clinical	clinical	ADJ
ajlm-2384	83	19	laboratories	laboratory	NOUN
ajlm-2384	83	20	for	for	ADP
ajlm-2384	83	21	detection	detection	NOUN
ajlm-2384	83	22	of	of	ADP
ajlm-2384	83	23	the	the	DET
ajlm-2384	83	24	m.3243a	m.3243a	NOUN
ajlm-2384	83	25	>	>	NOUN
ajlm-2384	83	26	g	g	NOUN
ajlm-2384	83	27	variant	variant	NOUN
ajlm-2384	83	28	.	.	PUNCT
ajlm-2384	84	1	however	however	ADV
ajlm-2384	84	2	,	,	PUNCT
ajlm-2384	84	3	it	it	PRON
ajlm-2384	84	4	is	be	AUX
ajlm-2384	84	5	unable	unable	ADJ
ajlm-2384	84	6	to	to	PART
ajlm-2384	84	7	detect	detect	VERB
ajlm-2384	84	8	heteroplasmy	heteroplasmy	ADJ
ajlm-2384	84	9	levels	level	NOUN
ajlm-2384	84	10	below	below	ADP
ajlm-2384	84	11	approximately	approximately	ADV
ajlm-2384	84	12	5	5	NUM
ajlm-2384	84	13	%	%	NOUN
ajlm-2384	84	14	and	and	CCONJ
ajlm-2384	84	15	is	be	AUX
ajlm-2384	84	16	not	not	PART
ajlm-2384	84	17	quantitative.15	quantitative.15	NOUN
ajlm-2384	84	18	in	in	ADP
ajlm-2384	84	19	contrast	contrast	NOUN
ajlm-2384	84	20	,	,	PUNCT
ajlm-2384	84	21	methods	method	NOUN
ajlm-2384	84	22	such	such	ADJ
ajlm-2384	84	23	as	as	ADP
ajlm-2384	84	24	next	next	ADJ
ajlm-2384	84	25	generation	generation	NOUN
ajlm-2384	84	26	sequencing	sequencing	NOUN
ajlm-2384	84	27	,	,	PUNCT
ajlm-2384	84	28	pyrosequencing	pyrosequencing	NOUN
ajlm-2384	84	29	,	,	PUNCT
ajlm-2384	84	30	real	real	ADJ
ajlm-2384	84	31	-	-	PUNCT
ajlm-2384	84	32	time	time	NOUN
ajlm-2384	84	33	pcr	pcr	ADJ
ajlm-2384	84	34	and	and	CCONJ
ajlm-2384	84	35	ligation	ligation	NOUN
ajlm-2384	84	36	-	-	PUNCT
ajlm-2384	84	37	mediated	mediate	VERB
ajlm-2384	84	38	pcr	pcr	NOUN
ajlm-2384	84	39	have	have	VERB
ajlm-2384	84	40	the	the	DET
ajlm-2384	84	41	advantage	advantage	NOUN
ajlm-2384	84	42	of	of	ADP
ajlm-2384	84	43	accurately	accurately	ADV
ajlm-2384	84	44	detecting	detect	VERB
ajlm-2384	84	45	much	much	ADV
ajlm-2384	84	46	lower	low	ADJ
ajlm-2384	84	47	heteroplasmy	heteroplasmy	NOUN
ajlm-2384	84	48	levels,16	levels,16	VERB
ajlm-2384	84	49	although	although	SCONJ
ajlm-2384	84	50	due	due	ADP
ajlm-2384	84	51	to	to	ADP
ajlm-2384	84	52	their	their	PRON
ajlm-2384	84	53	higher	high	ADJ
ajlm-2384	84	54	costs	cost	NOUN
ajlm-2384	84	55	,	,	PUNCT
ajlm-2384	84	56	these	these	DET
ajlm-2384	84	57	techniques	technique	NOUN
ajlm-2384	84	58	are	be	AUX
ajlm-2384	84	59	not	not	PART
ajlm-2384	84	60	routinely	routinely	ADV
ajlm-2384	84	61	available	available	ADJ
ajlm-2384	84	62	in	in	ADP
ajlm-2384	84	63	most	most	ADJ
ajlm-2384	84	64	public	public	ADJ
ajlm-2384	84	65	clinical	clinical	ADJ
ajlm-2384	84	66	laboratories	laboratory	NOUN
ajlm-2384	84	67	.	.	PUNCT
ajlm-2384	85	1	there	there	PRON
ajlm-2384	85	2	is	be	VERB
ajlm-2384	85	3	no	no	DET
ajlm-2384	85	4	cure	cure	NOUN
ajlm-2384	85	5	for	for	ADP
ajlm-2384	85	6	midd	midd	NOUN
ajlm-2384	85	7	,	,	PUNCT
ajlm-2384	85	8	and	and	CCONJ
ajlm-2384	85	9	treatment	treatment	NOUN
ajlm-2384	85	10	mainly	mainly	ADV
ajlm-2384	85	11	focuses	focus	VERB
ajlm-2384	85	12	on	on	ADP
ajlm-2384	85	13	managing	manage	VERB
ajlm-2384	85	14	disease	disease	NOUN
ajlm-2384	85	15	progression	progression	NOUN
ajlm-2384	85	16	and	and	CCONJ
ajlm-2384	85	17	minimising	minimise	VERB
ajlm-2384	85	18	severity	severity	NOUN
ajlm-2384	85	19	of	of	ADP
ajlm-2384	85	20	complications	complication	NOUN
ajlm-2384	85	21	in	in	ADP
ajlm-2384	85	22	order	order	NOUN
ajlm-2384	85	23	to	to	PART
ajlm-2384	85	24	enhance	enhance	VERB
ajlm-2384	85	25	the	the	DET
ajlm-2384	85	26	quality	quality	NOUN
ajlm-2384	85	27	of	of	ADP
ajlm-2384	85	28	life	life	NOUN
ajlm-2384	85	29	for	for	ADP
ajlm-2384	85	30	affected	affected	ADJ
ajlm-2384	85	31	individuals.13	individuals.13	NOUN
ajlm-2384	85	32	as	as	SCONJ
ajlm-2384	85	33	is	be	AUX
ajlm-2384	85	34	evident	evident	ADJ
ajlm-2384	85	35	from	from	ADP
ajlm-2384	85	36	this	this	DET
ajlm-2384	85	37	study	study	NOUN
ajlm-2384	85	38	,	,	PUNCT
ajlm-2384	85	39	cardiac	cardiac	ADJ
ajlm-2384	85	40	abnormalities	abnormality	NOUN
ajlm-2384	85	41	are	be	AUX
ajlm-2384	85	42	common	common	ADJ
ajlm-2384	85	43	in	in	ADP
ajlm-2384	85	44	patients	patient	NOUN
ajlm-2384	85	45	with	with	ADP
ajlm-2384	85	46	midd	midd	PRON
ajlm-2384	85	47	and	and	CCONJ
ajlm-2384	85	48	can	can	AUX
ajlm-2384	85	49	contribute	contribute	VERB
ajlm-2384	85	50	to	to	ADP
ajlm-2384	85	51	premature	premature	ADJ
ajlm-2384	85	52	death	death	NOUN
ajlm-2384	85	53	.	.	PUNCT
ajlm-2384	86	1	thus	thus	ADV
ajlm-2384	86	2	,	,	PUNCT
ajlm-2384	86	3	echocardiography	echocardiography	NOUN
ajlm-2384	86	4	and	and	CCONJ
ajlm-2384	86	5	regular	regular	ADJ
ajlm-2384	86	6	electrocardiography	electrocardiography	NOUN
ajlm-2384	86	7	should	should	AUX
ajlm-2384	86	8	form	form	VERB
ajlm-2384	86	9	part	part	NOUN
ajlm-2384	86	10	of	of	ADP
ajlm-2384	86	11	the	the	DET
ajlm-2384	86	12	standard	standard	ADJ
ajlm-2384	86	13	evaluation	evaluation	NOUN
ajlm-2384	86	14	for	for	ADP
ajlm-2384	86	15	midd	midd	NOUN
ajlm-2384	86	16	.	.	PUNCT
ajlm-2384	87	1	optimal	optimal	ADJ
ajlm-2384	87	2	patient	patient	ADJ
ajlm-2384	87	3	management	management	NOUN
ajlm-2384	87	4	in	in	ADP
ajlm-2384	87	5	midd	midd	NOUN
ajlm-2384	87	6	requires	require	VERB
ajlm-2384	87	7	a	a	DET
ajlm-2384	87	8	multidisciplinary	multidisciplinary	ADJ
ajlm-2384	87	9	approach	approach	NOUN
ajlm-2384	87	10	,	,	PUNCT
ajlm-2384	87	11	including	include	VERB
ajlm-2384	87	12	supportive	supportive	ADJ
ajlm-2384	87	13	therapy	therapy	NOUN
ajlm-2384	87	14	and	and	CCONJ
ajlm-2384	87	15	genetic	genetic	ADJ
ajlm-2384	87	16	counselling	counselling	NOUN
ajlm-2384	87	17	.	.	PUNCT
ajlm-2384	88	1	these	these	PRON
ajlm-2384	88	2	should	should	AUX
ajlm-2384	88	3	be	be	AUX
ajlm-2384	88	4	offered	offer	VERB
ajlm-2384	88	5	to	to	ADP
ajlm-2384	88	6	all	all	DET
ajlm-2384	88	7	available	available	ADJ
ajlm-2384	88	8	maternal	maternal	ADJ
ajlm-2384	88	9	relatives	relative	NOUN
ajlm-2384	88	10	to	to	PART
ajlm-2384	88	11	provide	provide	VERB
ajlm-2384	88	12	information	information	NOUN
ajlm-2384	88	13	on	on	ADP
ajlm-2384	88	14	the	the	DET
ajlm-2384	88	15	mode	mode	NOUN
ajlm-2384	88	16	of	of	ADP
ajlm-2384	88	17	inheritance	inheritance	NOUN
ajlm-2384	88	18	and	and	CCONJ
ajlm-2384	88	19	enable	enable	VERB
ajlm-2384	88	20	informed	informed	ADJ
ajlm-2384	88	21	choices	choice	NOUN
ajlm-2384	88	22	and	and	CCONJ
ajlm-2384	88	23	considerations	consideration	NOUN
ajlm-2384	88	24	for	for	ADP
ajlm-2384	88	25	family	family	NOUN
ajlm-2384	88	26	planning.17	planning.17	NOUN
ajlm-2384	88	27	considering	consider	VERB
ajlm-2384	88	28	that	that	SCONJ
ajlm-2384	88	29	symptoms	symptom	NOUN
ajlm-2384	88	30	of	of	ADP
ajlm-2384	88	31	diabetes	diabetes	NOUN
ajlm-2384	88	32	are	be	AUX
ajlm-2384	88	33	often	often	ADV
ajlm-2384	88	34	the	the	DET
ajlm-2384	88	35	reason	reason	NOUN
ajlm-2384	88	36	for	for	ADP
ajlm-2384	88	37	the	the	DET
ajlm-2384	88	38	initial	initial	ADJ
ajlm-2384	88	39	health	health	NOUN
ajlm-2384	88	40	-	-	PUNCT
ajlm-2384	88	41	seeking	seek	VERB
ajlm-2384	88	42	behaviour	behaviour	NOUN
ajlm-2384	88	43	in	in	ADP
ajlm-2384	88	44	most	most	ADJ
ajlm-2384	88	45	midd	midd	NOUN
ajlm-2384	88	46	patients	patient	NOUN
ajlm-2384	88	47	,	,	PUNCT
ajlm-2384	88	48	it	it	PRON
ajlm-2384	88	49	is	be	AUX
ajlm-2384	88	50	probable	probable	ADJ
ajlm-2384	88	51	that	that	SCONJ
ajlm-2384	88	52	many	many	ADJ
ajlm-2384	88	53	cases	case	NOUN
ajlm-2384	88	54	remain	remain	VERB
ajlm-2384	88	55	undiagnosed	undiagnosed	ADJ
ajlm-2384	88	56	in	in	ADP
ajlm-2384	88	57	our	our	PRON
ajlm-2384	88	58	local	local	ADJ
ajlm-2384	88	59	setting	setting	NOUN
ajlm-2384	88	60	.	.	PUNCT
ajlm-2384	89	1	a	a	DET
ajlm-2384	89	2	high	high	ADJ
ajlm-2384	89	3	index	index	NOUN
ajlm-2384	89	4	of	of	ADP
ajlm-2384	89	5	suspicion	suspicion	NOUN
ajlm-2384	89	6	should	should	AUX
ajlm-2384	89	7	be	be	AUX
ajlm-2384	89	8	maintained	maintain	VERB
ajlm-2384	89	9	when	when	SCONJ
ajlm-2384	89	10	encountering	encounter	VERB
ajlm-2384	89	11	a	a	DET
ajlm-2384	89	12	family	family	NOUN
ajlm-2384	89	13	history	history	NOUN
ajlm-2384	89	14	of	of	ADP
ajlm-2384	89	15	diabetes	diabetes	NOUN
ajlm-2384	89	16	and	and	CCONJ
ajlm-2384	89	17	impaired	impaired	ADJ
ajlm-2384	89	18	hearing	hearing	NOUN
ajlm-2384	89	19	.	.	PUNCT
ajlm-2384	90	1	all	all	DET
ajlm-2384	90	2	maternal	maternal	ADJ
ajlm-2384	90	3	offspring	offspring	NOUN
ajlm-2384	90	4	and	and	CCONJ
ajlm-2384	90	5	relatives	relative	NOUN
ajlm-2384	90	6	of	of	ADP
ajlm-2384	90	7	an	an	DET
ajlm-2384	90	8	individual	individual	NOUN
ajlm-2384	90	9	with	with	ADP
ajlm-2384	90	10	midd	midd	NOUN
ajlm-2384	90	11	are	be	AUX
ajlm-2384	90	12	potential	potential	ADJ
ajlm-2384	90	13	carriers	carrier	NOUN
ajlm-2384	90	14	of	of	ADP
ajlm-2384	90	15	a	a	DET
ajlm-2384	90	16	pathological	pathological	ADJ
ajlm-2384	90	17	variant	variant	NOUN
ajlm-2384	90	18	and	and	CCONJ
ajlm-2384	90	19	should	should	AUX
ajlm-2384	90	20	be	be	AUX
ajlm-2384	90	21	offered	offer	VERB
ajlm-2384	90	22	screening	screening	NOUN
ajlm-2384	90	23	.	.	PUNCT
ajlm-2384	91	1	acknowledgements	acknowledgement	NOUN
ajlm-2384	91	2	competing	compete	VERB
ajlm-2384	91	3	interests	interest	NOUN
ajlm-2384	91	4	the	the	DET
ajlm-2384	91	5	authors	author	NOUN
ajlm-2384	91	6	declare	declare	VERB
ajlm-2384	91	7	that	that	SCONJ
ajlm-2384	91	8	they	they	PRON
ajlm-2384	91	9	have	have	VERB
ajlm-2384	91	10	no	no	DET
ajlm-2384	91	11	financial	financial	ADJ
ajlm-2384	91	12	or	or	CCONJ
ajlm-2384	91	13	personal	personal	ADJ
ajlm-2384	91	14	relationship(s	relationship(s	NOUN
ajlm-2384	91	15	)	)	PUNCT
ajlm-2384	91	16	that	that	PRON
ajlm-2384	91	17	may	may	AUX
ajlm-2384	91	18	have	have	AUX
ajlm-2384	91	19	inappropriately	inappropriately	ADV
ajlm-2384	91	20	influenced	influence	VERB
ajlm-2384	91	21	them	they	PRON
ajlm-2384	91	22	in	in	ADP
ajlm-2384	91	23	writing	write	VERB
ajlm-2384	91	24	this	this	DET
ajlm-2384	91	25	article	article	NOUN
ajlm-2384	91	26	.	.	PUNCT
ajlm-2384	92	1	authors	author	NOUN
ajlm-2384	92	2	’	'	PUNCT
ajlm-2384	92	3	contributions	contribution	NOUN
ajlm-2384	92	4	h.m	h.m	PROPN
ajlm-2384	92	5	.	.	PROPN
ajlm-2384	92	6	drafted	draft	VERB
ajlm-2384	92	7	the	the	DET
ajlm-2384	92	8	original	original	ADJ
ajlm-2384	92	9	article	article	NOUN
ajlm-2384	92	10	.	.	PUNCT
ajlm-2384	93	1	t.k	t.k	AUX
ajlm-2384	93	2	.	.	PROPN
ajlm-2384	93	3	performed	perform	VERB
ajlm-2384	93	4	clinical	clinical	ADJ
ajlm-2384	93	5	examinations	examination	NOUN
ajlm-2384	93	6	and	and	CCONJ
ajlm-2384	93	7	investigations	investigation	NOUN
ajlm-2384	93	8	of	of	ADP
ajlm-2384	93	9	patients	patient	NOUN
ajlm-2384	93	10	,	,	PUNCT
ajlm-2384	93	11	and	and	CCONJ
ajlm-2384	93	12	editing	editing	NOUN
ajlm-2384	93	13	of	of	ADP
ajlm-2384	93	14	the	the	DET
ajlm-2384	93	15	article	article	NOUN
ajlm-2384	93	16	.	.	PUNCT
ajlm-2384	94	1	s.m	s.m	PROPN
ajlm-2384	94	2	.	.	PROPN
ajlm-2384	94	3	was	be	AUX
ajlm-2384	94	4	responsible	responsible	ADJ
ajlm-2384	94	5	for	for	ADP
ajlm-2384	94	6	the	the	DET
ajlm-2384	94	7	genetic	genetic	ADJ
ajlm-2384	94	8	studies	study	NOUN
ajlm-2384	94	9	,	,	PUNCT
ajlm-2384	94	10	interpretation	interpretation	NOUN
ajlm-2384	94	11	of	of	ADP
ajlm-2384	94	12	genetic	genetic	ADJ
ajlm-2384	94	13	results	result	NOUN
ajlm-2384	94	14	,	,	PUNCT
ajlm-2384	94	15	and	and	CCONJ
ajlm-2384	94	16	editing	editing	NOUN
ajlm-2384	94	17	of	of	ADP
ajlm-2384	94	18	the	the	DET
ajlm-2384	94	19	article	article	NOUN
ajlm-2384	94	20	.	.	PUNCT
ajlm-2384	95	1	e.m.h	e.m.h	PROPN
ajlm-2384	95	2	.	.	PROPN
ajlm-2384	95	3	performed	perform	VERB
ajlm-2384	95	4	genetic	genetic	ADJ
ajlm-2384	95	5	counselling	counselling	NOUN
ajlm-2384	95	6	and	and	CCONJ
ajlm-2384	95	7	investigations	investigation	NOUN
ajlm-2384	95	8	of	of	ADP
ajlm-2384	95	9	patients	patient	NOUN
ajlm-2384	95	10	,	,	PUNCT
ajlm-2384	95	11	and	and	CCONJ
ajlm-2384	95	12	editing	editing	NOUN
ajlm-2384	95	13	of	of	ADP
ajlm-2384	95	14	the	the	DET
ajlm-2384	95	15	article	article	NOUN
ajlm-2384	95	16	.	.	PUNCT
ajlm-2384	96	1	b.c.-m	b.c.-m	PROPN
ajlm-2384	96	2	.	.	PUNCT
ajlm-2384	96	3	conceptualised	conceptualise	VERB
ajlm-2384	96	4	,	,	PUNCT
ajlm-2384	96	5	edited	edit	VERB
ajlm-2384	96	6	the	the	DET
ajlm-2384	96	7	article	article	NOUN
ajlm-2384	96	8	and	and	CCONJ
ajlm-2384	96	9	supervised	supervise	VERB
ajlm-2384	96	10	the	the	DET
ajlm-2384	96	11	study	study	NOUN
ajlm-2384	96	12	.	.	PUNCT
ajlm-2384	97	1	sources	source	NOUN
ajlm-2384	97	2	of	of	ADP
ajlm-2384	97	3	support	support	NOUN
ajlm-2384	97	4	this	this	DET
ajlm-2384	97	5	research	research	NOUN
ajlm-2384	97	6	received	receive	VERB
ajlm-2384	97	7	no	no	DET
ajlm-2384	97	8	specific	specific	ADJ
ajlm-2384	97	9	grant	grant	NOUN
ajlm-2384	97	10	from	from	ADP
ajlm-2384	97	11	any	any	DET
ajlm-2384	97	12	funding	funding	NOUN
ajlm-2384	97	13	agency	agency	NOUN
ajlm-2384	97	14	in	in	ADP
ajlm-2384	97	15	the	the	DET
ajlm-2384	97	16	public	public	ADJ
ajlm-2384	97	17	,	,	PUNCT
ajlm-2384	97	18	commercial	commercial	ADJ
ajlm-2384	97	19	,	,	PUNCT
ajlm-2384	97	20	or	or	CCONJ
ajlm-2384	97	21	not	not	PART
ajlm-2384	97	22	-	-	PUNCT
ajlm-2384	97	23	for	for	ADP
ajlm-2384	97	24	-	-	PUNCT
ajlm-2384	97	25	profit	profit	NOUN
ajlm-2384	97	26	sectors	sector	NOUN
ajlm-2384	97	27	.	.	PUNCT
ajlm-2384	98	1	data	datum	NOUN
ajlm-2384	98	2	availability	availability	NOUN
ajlm-2384	98	3	the	the	DET
ajlm-2384	98	4	authors	author	NOUN
ajlm-2384	98	5	confirm	confirm	VERB
ajlm-2384	98	6	that	that	SCONJ
ajlm-2384	98	7	the	the	DET
ajlm-2384	98	8	data	datum	NOUN
ajlm-2384	98	9	supporting	support	VERB
ajlm-2384	98	10	the	the	DET
ajlm-2384	98	11	findings	finding	NOUN
ajlm-2384	98	12	of	of	ADP
ajlm-2384	98	13	this	this	DET
ajlm-2384	98	14	study	study	NOUN
ajlm-2384	98	15	are	be	AUX
ajlm-2384	98	16	available	available	ADJ
ajlm-2384	98	17	within	within	ADP
ajlm-2384	98	18	the	the	DET
ajlm-2384	98	19	article	article	NOUN
ajlm-2384	98	20	.	.	PUNCT
ajlm-2384	99	1	disclaimer	disclaimer	VERB
ajlm-2384	99	2	the	the	DET
ajlm-2384	99	3	views	view	NOUN
ajlm-2384	99	4	and	and	CCONJ
ajlm-2384	99	5	opinions	opinion	NOUN
ajlm-2384	99	6	expressed	express	VERB
ajlm-2384	99	7	in	in	ADP
ajlm-2384	99	8	this	this	DET
ajlm-2384	99	9	article	article	NOUN
ajlm-2384	99	10	are	be	AUX
ajlm-2384	99	11	those	those	PRON
ajlm-2384	99	12	of	of	ADP
ajlm-2384	99	13	the	the	DET
ajlm-2384	99	14	authors	author	NOUN
ajlm-2384	99	15	and	and	CCONJ
ajlm-2384	99	16	do	do	AUX
ajlm-2384	99	17	not	not	PART
ajlm-2384	99	18	necessarily	necessarily	ADV
ajlm-2384	99	19	reflect	reflect	VERB
ajlm-2384	99	20	the	the	DET
ajlm-2384	99	21	official	official	ADJ
ajlm-2384	99	22	policy	policy	NOUN
ajlm-2384	99	23	or	or	CCONJ
ajlm-2384	99	24	position	position	NOUN
ajlm-2384	99	25	of	of	ADP
ajlm-2384	99	26	any	any	DET
ajlm-2384	99	27	affiliated	affiliated	ADJ
ajlm-2384	99	28	institutions	institution	NOUN
ajlm-2384	99	29	or	or	CCONJ
ajlm-2384	99	30	organisations	organisation	NOUN
ajlm-2384	99	31	of	of	ADP
ajlm-2384	99	32	the	the	DET
ajlm-2384	99	33	authors	author	NOUN
ajlm-2384	99	34	and	and	CCONJ
ajlm-2384	99	35	the	the	DET
ajlm-2384	99	36	publisher	publisher	NOUN
ajlm-2384	99	37	.	.	PUNCT
ajlm-2384	100	1	references	reference	NOUN
ajlm-2384	100	2	schlieben	schlieben	PROPN
ajlm-2384	100	3	ld	ld	PROPN
ajlm-2384	100	4	,	,	PUNCT
ajlm-2384	100	5	prokisch	prokisch	PROPN
ajlm-2384	100	6	h.	h.	PROPN
ajlm-2384	101	1	the	the	DET
ajlm-2384	101	2	dimensions	dimension	NOUN
ajlm-2384	101	3	of	of	ADP
ajlm-2384	101	4	primary	primary	ADJ
ajlm-2384	101	5	mitochondrial	mitochondrial	ADJ
ajlm-2384	101	6	disorders	disorder	NOUN
ajlm-2384	101	7	.	.	PUNCT
ajlm-2384	102	1	front	front	ADJ
ajlm-2384	102	2	cell	cell	NOUN
ajlm-2384	102	3	dev	dev	PROPN
ajlm-2384	102	4	biol	biol	NOUN
ajlm-2384	102	5	.	.	PUNCT
ajlm-2384	103	1	2020;8:600079	2020;8:600079	NUM
ajlm-2384	103	2	.	.	PUNCT
ajlm-2384	104	1	https://doi.org/10.3389/fcell.2020.600079	https://doi.org/10.3389/fcell.2020.600079	PROPN
ajlm-2384	104	2	ali	ali	PROPN
ajlm-2384	104	3	as	as	ADP
ajlm-2384	104	4	,	,	PUNCT
ajlm-2384	104	5	ekinci	ekinci	PROPN
ajlm-2384	104	6	ei	ei	PROPN
ajlm-2384	104	7	,	,	PUNCT
ajlm-2384	104	8	pyrlis	pyrlis	PROPN
ajlm-2384	104	9	f.	f.	PROPN
ajlm-2384	104	10	maternally	maternally	PROPN
ajlm-2384	104	11	inherited	inherit	VERB
ajlm-2384	104	12	diabetes	diabetes	NOUN
ajlm-2384	104	13	and	and	CCONJ
ajlm-2384	104	14	deafness	deafness	NOUN
ajlm-2384	104	15	(	(	PUNCT
ajlm-2384	104	16	midd	midd	NOUN
ajlm-2384	104	17	):	):	PUNCT
ajlm-2384	104	18	an	an	DET
ajlm-2384	104	19	uncommon	uncommon	ADJ
ajlm-2384	104	20	but	but	CCONJ
ajlm-2384	104	21	important	important	ADJ
ajlm-2384	104	22	cause	cause	NOUN
ajlm-2384	104	23	of	of	ADP
ajlm-2384	104	24	diabetes	diabetes	NOUN
ajlm-2384	104	25	.	.	PUNCT
ajlm-2384	105	1	endocr	endocr	PROPN
ajlm-2384	105	2	metab	metab	PROPN
ajlm-2384	105	3	sci	sci	PROPN
ajlm-2384	105	4	.	.	PUNCT
ajlm-2384	106	1	2021;2:100074	2021;2:100074	NUM
ajlm-2384	106	2	.	.	PUNCT
ajlm-2384	107	1	https://doi.org/10.1016/j.endmts.2020.100074	https://doi.org/10.1016/j.endmts.2020.100074	PROPN
ajlm-2384	107	2	wang	wang	PROPN
ajlm-2384	107	3	m	m	PROPN
ajlm-2384	107	4	,	,	PUNCT
ajlm-2384	107	5	liu	liu	PROPN
ajlm-2384	107	6	h	h	PROPN
ajlm-2384	107	7	,	,	PUNCT
ajlm-2384	107	8	zheng	zheng	PROPN
ajlm-2384	107	9	j	j	PROPN
ajlm-2384	107	10	,	,	PUNCT
ajlm-2384	107	11	et	et	PROPN
ajlm-2384	107	12	al	al	PROPN
ajlm-2384	107	13	.	.	PUNCT
ajlm-2384	108	1	a	a	DET
ajlm-2384	108	2	deafness	deafness	NOUN
ajlm-2384	108	3	-	-	PUNCT
ajlm-2384	108	4	and	and	CCONJ
ajlm-2384	108	5	diabetes	diabetes	NOUN
ajlm-2384	108	6	-	-	PUNCT
ajlm-2384	108	7	associated	associate	VERB
ajlm-2384	108	8	trna	trna	NOUN
ajlm-2384	108	9	mutation	mutation	NOUN
ajlm-2384	108	10	causes	cause	VERB
ajlm-2384	108	11	deficient	deficient	ADJ
ajlm-2384	108	12	pseudouridinylation	pseudouridinylation	NOUN
ajlm-2384	108	13	at	at	ADP
ajlm-2384	108	14	position	position	NOUN
ajlm-2384	108	15	55	55	NUM
ajlm-2384	108	16	in	in	ADP
ajlm-2384	108	17	trnaglu	trnaglu	NOUN
ajlm-2384	108	18	and	and	CCONJ
ajlm-2384	108	19	mitochondrial	mitochondrial	ADJ
ajlm-2384	108	20	dysfunction	dysfunction	NOUN
ajlm-2384	108	21	.	.	PUNCT
ajlm-2384	109	1	j	j	PROPN
ajlm-2384	109	2	biol	biol	PROPN
ajlm-2384	109	3	chem	chem	NOUN
ajlm-2384	109	4	.	.	PUNCT
ajlm-2384	110	1	2016;291(40):21029–21041	2016;291(40):21029–21041	NUM
ajlm-2384	110	2	.	.	PUNCT
ajlm-2384	111	1	https://doi.org/10.1074/jbc.m116.739482	https://doi.org/10.1074/jbc.m116.739482	PROPN
ajlm-2384	111	2	iwasaki	iwasaki	PROPN
ajlm-2384	111	3	n	n	CCONJ
ajlm-2384	111	4	,	,	PUNCT
ajlm-2384	111	5	babazono	babazono	PROPN
ajlm-2384	111	6	t	t	PROPN
ajlm-2384	111	7	,	,	PUNCT
ajlm-2384	111	8	tsuchiya	tsuchiya	PROPN
ajlm-2384	112	1	k	k	PROPN
ajlm-2384	112	2	,	,	PUNCT
ajlm-2384	112	3	et	et	PROPN
ajlm-2384	112	4	al	al	PROPN
ajlm-2384	112	5	.	.	PUNCT
ajlm-2384	113	1	prevalence	prevalence	NOUN
ajlm-2384	113	2	of	of	ADP
ajlm-2384	113	3	a	a	PRON
ajlm-2384	113	4	-	-	PUNCT
ajlm-2384	113	5	to	to	ADP
ajlm-2384	113	6	-	-	PUNCT
ajlm-2384	113	7	g	g	NOUN
ajlm-2384	113	8	mutation	mutation	NOUN
ajlm-2384	113	9	at	at	ADP
ajlm-2384	113	10	nucleotide	nucleotide	NOUN
ajlm-2384	113	11	3243	3243	NUM
ajlm-2384	113	12	of	of	ADP
ajlm-2384	113	13	the	the	DET
ajlm-2384	113	14	mitochondrial	mitochondrial	ADJ
ajlm-2384	113	15	trna	trna	NOUN
ajlm-2384	113	16	leu	leu	PROPN
ajlm-2384	113	17	(	(	PUNCT
ajlm-2384	113	18	uur	uur	PROPN
ajlm-2384	113	19	)	)	PUNCT
ajlm-2384	113	20	gene	gene	NOUN
ajlm-2384	113	21	in	in	ADP
ajlm-2384	113	22	japanese	japanese	ADJ
ajlm-2384	113	23	patients	patient	NOUN
ajlm-2384	113	24	with	with	ADP
ajlm-2384	113	25	diabetes	diabetes	NOUN
ajlm-2384	113	26	mellitus	mellitus	NOUN
ajlm-2384	113	27	and	and	CCONJ
ajlm-2384	113	28	end	end	VERB
ajlm-2384	113	29	stage	stage	NOUN
ajlm-2384	113	30	renal	renal	ADJ
ajlm-2384	113	31	disease	disease	NOUN
ajlm-2384	113	32	.	.	PUNCT
ajlm-2384	114	1	j	j	PROPN
ajlm-2384	114	2	hum	hum	PROPN
ajlm-2384	114	3	genet	genet	PROPN
ajlm-2384	114	4	.	.	PUNCT
ajlm-2384	115	1	2001;46	2001;46	NUM
ajlm-2384	115	2	:	:	PUNCT
ajlm-2384	116	1	330–334	330–334	NUM
ajlm-2384	116	2	.	.	PUNCT
ajlm-2384	117	1	https://doi.org/10.1007/s100380170068	https://doi.org/10.1007/s100380170068	NUM
ajlm-2384	117	2	yang	yang	PROPN
ajlm-2384	117	3	m	m	PROPN
ajlm-2384	117	4	,	,	PUNCT
ajlm-2384	117	5	xu	xu	PROPN
ajlm-2384	118	1	l	l	NOUN
ajlm-2384	118	2	,	,	PUNCT
ajlm-2384	118	3	xu	xu	PROPN
ajlm-2384	119	1	c	c	X
ajlm-2384	119	2	,	,	PUNCT
ajlm-2384	119	3	et	et	PROPN
ajlm-2384	119	4	al	al	PROPN
ajlm-2384	119	5	.	.	PUNCT
ajlm-2384	120	1	the	the	DET
ajlm-2384	120	2	mutations	mutation	NOUN
ajlm-2384	120	3	and	and	CCONJ
ajlm-2384	120	4	clinical	clinical	ADJ
ajlm-2384	120	5	variability	variability	NOUN
ajlm-2384	120	6	in	in	ADP
ajlm-2384	120	7	maternally	maternally	ADV
ajlm-2384	120	8	inherited	inherit	VERB
ajlm-2384	120	9	diabetes	diabetes	NOUN
ajlm-2384	120	10	and	and	CCONJ
ajlm-2384	120	11	deafness	deafness	NOUN
ajlm-2384	120	12	:	:	PUNCT
ajlm-2384	120	13	an	an	DET
ajlm-2384	120	14	analysis	analysis	NOUN
ajlm-2384	120	15	of	of	ADP
ajlm-2384	120	16	161	161	NUM
ajlm-2384	120	17	patients	patient	NOUN
ajlm-2384	120	18	.	.	PUNCT
ajlm-2384	121	1	front	front	ADJ
ajlm-2384	121	2	endocrinol	endocrinol	NOUN
ajlm-2384	121	3	.	.	PUNCT
ajlm-2384	122	1	2021;12:728043	2021;12:728043	NUM
ajlm-2384	122	2	.	.	PUNCT
ajlm-2384	123	1	https://doi.org/10.3389/fendo.2021.728043	https://doi.org/10.3389/fendo.2021.728043	PROPN
ajlm-2384	123	2	ahmed	ahmed	AUX
ajlm-2384	123	3	st	st	AUX
ajlm-2384	123	4	.	.	PROPN
ajlm-2384	123	5	understanding	understand	VERB
ajlm-2384	123	6	the	the	DET
ajlm-2384	123	7	molecular	molecular	ADJ
ajlm-2384	123	8	mechanisms	mechanism	NOUN
ajlm-2384	123	9	of	of	ADP
ajlm-2384	123	10	mitochondrial	mitochondrial	ADJ
ajlm-2384	123	11	muscle	muscle	NOUN
ajlm-2384	123	12	disease	disease	NOUN
ajlm-2384	123	13	using	use	VERB
ajlm-2384	123	14	a	a	DET
ajlm-2384	123	15	quantitative	quantitative	NOUN
ajlm-2384	123	16	,	,	PUNCT
ajlm-2384	123	17	quadruple	quadruple	PROPN
ajlm-2384	123	18	immunofluorescent	immunofluorescent	VERB
ajlm-2384	123	19	assay	assay	PROPN
ajlm-2384	123	20	.	.	PUNCT
ajlm-2384	124	1	newcastle	newcastle	PROPN
ajlm-2384	124	2	university	university	PROPN
ajlm-2384	124	3	,	,	PUNCT
ajlm-2384	124	4	newcastle	newcastle	PROPN
ajlm-2384	124	5	upon	upon	SCONJ
ajlm-2384	124	6	tyne	tyne	PROPN
ajlm-2384	124	7	;	;	PUNCT
ajlm-2384	124	8	2020	2020	NUM
ajlm-2384	124	9	.	.	PUNCT
ajlm-2384	125	1	meldau	meldau	NOUN
ajlm-2384	125	2	s	s	PART
ajlm-2384	125	3	,	,	PUNCT
ajlm-2384	125	4	owen	owen	PROPN
ajlm-2384	125	5	ep	ep	PROPN
ajlm-2384	125	6	,	,	PUNCT
ajlm-2384	125	7	khan	khan	PROPN
ajlm-2384	125	8	k	k	PROPN
ajlm-2384	125	9	,	,	PUNCT
ajlm-2384	125	10	riordan	riordan	PROPN
ajlm-2384	125	11	gt	gt	PROPN
ajlm-2384	125	12	.	.	PROPN
ajlm-2384	126	1	mitochondrial	mitochondrial	ADJ
ajlm-2384	126	2	molecular	molecular	ADJ
ajlm-2384	126	3	genetic	genetic	ADJ
ajlm-2384	126	4	results	result	NOUN
ajlm-2384	126	5	in	in	ADP
ajlm-2384	126	6	a	a	DET
ajlm-2384	126	7	south	south	ADJ
ajlm-2384	126	8	african	african	ADJ
ajlm-2384	126	9	cohort	cohort	NOUN
ajlm-2384	126	10	:	:	PUNCT
ajlm-2384	126	11	divergent	divergent	ADJ
ajlm-2384	126	12	mitochondrial	mitochondrial	ADJ
ajlm-2384	126	13	and	and	CCONJ
ajlm-2384	126	14	nuclear	nuclear	ADJ
ajlm-2384	126	15	dna	dna	PROPN
ajlm-2384	126	16	findings	finding	NOUN
ajlm-2384	126	17	.	.	PUNCT
ajlm-2384	127	1	j	j	PROPN
ajlm-2384	127	2	clin	clin	PROPN
ajlm-2384	127	3	pathol	pathol	PROPN
ajlm-2384	127	4	.	.	PUNCT
ajlm-2384	128	1	2022;75(1):34–38	2022;75(1):34–38	X
ajlm-2384	128	2	.	.	PUNCT
ajlm-2384	128	3	https://doi.org/10.1136/jclinpath-2020-207026	https://doi.org/10.1136/jclinpath-2020-207026	PROPN
ajlm-2384	128	4	ameh	ameh	VERB
ajlm-2384	128	5	j	j	PROPN
ajlm-2384	128	6	,	,	PUNCT
ajlm-2384	128	7	godwin	godwin	PROPN
ajlm-2384	128	8	i	i	PROPN
ajlm-2384	128	9	,	,	PUNCT
ajlm-2384	128	10	obi	obi	PROPN
ajlm-2384	128	11	i	i	PROPN
ajlm-2384	128	12	,	,	PUNCT
ajlm-2384	128	13	puepet	puepet	PROPN
ajlm-2384	128	14	f	f	PROPN
ajlm-2384	128	15	,	,	PUNCT
ajlm-2384	128	16	aminu	aminu	PROPN
ajlm-2384	128	17	b	b	PROPN
ajlm-2384	128	18	,	,	PUNCT
ajlm-2384	128	19	suleiman	suleiman	PROPN
ajlm-2384	128	20	t.	t.	PROPN
ajlm-2384	128	21	the	the	DET
ajlm-2384	128	22	search	search	NOUN
ajlm-2384	128	23	for	for	ADP
ajlm-2384	128	24	mitochondrial	mitochondrial	ADJ
ajlm-2384	128	25	trnaleu	trnaleu	NOUN
ajlm-2384	128	26	(	(	PUNCT
ajlm-2384	128	27	uur	uur	NOUN
ajlm-2384	128	28	)	)	PUNCT
ajlm-2384	128	29	a3243	a3243	PROPN
ajlm-2384	128	30	g	g	PROPN
ajlm-2384	128	31	mutation	mutation	NOUN
ajlm-2384	128	32	among	among	ADP
ajlm-2384	128	33	type	type	NOUN
ajlm-2384	128	34	2	2	NUM
ajlm-2384	128	35	diabetes	diabetes	NOUN
ajlm-2384	128	36	mellitus	mellitus	NOUN
ajlm-2384	128	37	patients	patient	NOUN
ajlm-2384	128	38	in	in	ADP
ajlm-2384	128	39	the	the	DET
ajlm-2384	128	40	nigerian	nigerian	ADJ
ajlm-2384	128	41	population	population	NOUN
ajlm-2384	128	42	.	.	PUNCT
ajlm-2384	129	1	afr	afr	PROPN
ajlm-2384	129	2	j	j	PROPN
ajlm-2384	129	3	biotechnol	biotechnol	PROPN
ajlm-2384	129	4	.	.	PUNCT
ajlm-2384	130	1	2011;10(62):13383–13389	2011;10(62):13383–13389	NOUN
ajlm-2384	130	2	.	.	PUNCT
ajlm-2384	131	1	https://doi.org/10.5897/ajb11.1556	https://doi.org/10.5897/ajb11.1556	PROPN
ajlm-2384	131	2	mkaouar	mkaouar	NOUN
ajlm-2384	131	3	-	-	PUNCT
ajlm-2384	131	4	rebai	rebai	PROPN
ajlm-2384	131	5	e	e	NOUN
ajlm-2384	131	6	,	,	PUNCT
ajlm-2384	131	7	tlili	tlili	NOUN
ajlm-2384	131	8	a	a	PRON
ajlm-2384	131	9	,	,	PUNCT
ajlm-2384	131	10	masmoudi	masmoudi	PROPN
ajlm-2384	131	11	s	s	PROPN
ajlm-2384	131	12	,	,	PUNCT
ajlm-2384	131	13	et	et	PROPN
ajlm-2384	131	14	al	al	PROPN
ajlm-2384	131	15	.	.	PROPN
ajlm-2384	132	1	mutational	mutational	ADJ
ajlm-2384	132	2	analysis	analysis	NOUN
ajlm-2384	132	3	of	of	ADP
ajlm-2384	132	4	the	the	DET
ajlm-2384	132	5	mitochondrial	mitochondrial	ADJ
ajlm-2384	132	6	trnaleu	trnaleu	NOUN
ajlm-2384	132	7	(	(	PUNCT
ajlm-2384	132	8	uur	uur	NOUN
ajlm-2384	132	9	)	)	PUNCT
ajlm-2384	132	10	gene	gene	NOUN
ajlm-2384	132	11	in	in	ADP
ajlm-2384	132	12	tunisian	tunisian	ADJ
ajlm-2384	132	13	patients	patient	NOUN
ajlm-2384	132	14	with	with	ADP
ajlm-2384	132	15	mitochondrial	mitochondrial	ADJ
ajlm-2384	132	16	diseases	disease	NOUN
ajlm-2384	132	17	.	.	PUNCT
ajlm-2384	133	1	biochem	biochem	PROPN
ajlm-2384	133	2	biophys	biophy	VERB
ajlm-2384	133	3	res	re	NOUN
ajlm-2384	133	4	commun	commun	PROPN
ajlm-2384	133	5	.	.	PUNCT
ajlm-2384	134	1	2007;355(4):1031–1037	2007;355(4):1031–1037	X
ajlm-2384	134	2	.	.	PUNCT
ajlm-2384	135	1	https://doi.org/10.1016/j.bbrc.2007.02.083	https://doi.org/10.1016/j.bbrc.2007.02.083	PROPN
ajlm-2384	135	2	meyers	meyers	PROPN
ajlm-2384	135	3	a.	a.	NOUN
ajlm-2384	135	4	significance	significance	NOUN
ajlm-2384	135	5	,	,	PUNCT
ajlm-2384	135	6	definition	definition	NOUN
ajlm-2384	135	7	,	,	PUNCT
ajlm-2384	135	8	classification	classification	NOUN
ajlm-2384	135	9	and	and	CCONJ
ajlm-2384	135	10	risk	risk	NOUN
ajlm-2384	135	11	factors	factor	NOUN
ajlm-2384	135	12	of	of	ADP
ajlm-2384	135	13	chronic	chronic	ADJ
ajlm-2384	135	14	kidney	kidney	NOUN
ajlm-2384	135	15	disease	disease	NOUN
ajlm-2384	135	16	in	in	ADP
ajlm-2384	135	17	south	south	PROPN
ajlm-2384	135	18	africa	africa	PROPN
ajlm-2384	135	19	.	.	PUNCT
ajlm-2384	136	1	s	s	PROPN
ajlm-2384	136	2	afr	afr	PROPN
ajlm-2384	136	3	med	med	PROPN
ajlm-2384	136	4	j.	j.	PROPN
ajlm-2384	137	1	2015;105(3):233–236	2015;105(3):233–236	PROPN
ajlm-2384	137	2	.	.	PUNCT
ajlm-2384	138	1	https://doi.org/10.7196/samj.9412	https://doi.org/10.7196/samj.9412	PROPN
ajlm-2384	138	2	american	american	ADJ
ajlm-2384	138	3	diabetes	diabetes	PROPN
ajlm-2384	138	4	assocciation	assocciation	NOUN
ajlm-2384	138	5	professional	professional	ADJ
ajlm-2384	138	6	practice	practice	NOUN
ajlm-2384	138	7	committee	committee	NOUN
ajlm-2384	138	8	.	.	PUNCT
ajlm-2384	139	1	diagnosis	diagnosis	NOUN
ajlm-2384	139	2	and	and	CCONJ
ajlm-2384	139	3	classification	classification	NOUN
ajlm-2384	139	4	of	of	ADP
ajlm-2384	139	5	diabetes	diabetes	NOUN
ajlm-2384	139	6	:	:	PUNCT
ajlm-2384	139	7	standards	standard	NOUN
ajlm-2384	139	8	of	of	ADP
ajlm-2384	139	9	care	care	NOUN
ajlm-2384	139	10	in	in	ADP
ajlm-2384	139	11	diabetes	diabetes	NOUN
ajlm-2384	139	12	–	–	PUNCT
ajlm-2384	139	13	2024	2024	NUM
ajlm-2384	139	14	.	.	PUNCT
ajlm-2384	140	1	diabetes	diabetes	NOUN
ajlm-2384	140	2	care	care	NOUN
ajlm-2384	140	3	.	.	PUNCT
ajlm-2384	141	1	2024;47(supplement_1):s20	2024;47(supplement_1):s20	NUM
ajlm-2384	141	2	–	–	PUNCT
ajlm-2384	141	3	s42	s42	NOUN
ajlm-2384	141	4	.	.	PUNCT
ajlm-2384	142	1	https://doi.org/10.2337/dc24-s002	https://doi.org/10.2337/dc24-s002	PROPN
ajlm-2384	142	2	van	van	PROPN
ajlm-2384	142	3	den	den	PROPN
ajlm-2384	142	4	ouveland	ouveland	PROPN
ajlm-2384	142	5	j	j	PROPN
ajlm-2384	142	6	,	,	PUNCT
ajlm-2384	142	7	lemkes	lemke	VERB
ajlm-2384	142	8	h	h	PROPN
ajlm-2384	142	9	,	,	PUNCT
ajlm-2384	142	10	ruitembeck	ruitembeck	PROPN
ajlm-2384	142	11	w	w	PROPN
ajlm-2384	142	12	,	,	PUNCT
ajlm-2384	142	13	et	et	PROPN
ajlm-2384	142	14	al	al	PROPN
ajlm-2384	142	15	.	.	PROPN
ajlm-2384	143	1	mutation	mutation	NOUN
ajlm-2384	143	2	in	in	ADP
ajlm-2384	143	3	mitochondrial	mitochondrial	ADJ
ajlm-2384	143	4	trna	trna	NOUN
ajlm-2384	143	5	leu	leu	PROPN
ajlm-2384	143	6	(	(	PUNCT
ajlm-2384	143	7	uur	uur	PROPN
ajlm-2384	143	8	)	)	PUNCT
ajlm-2384	143	9	gene	gene	NOUN
ajlm-2384	143	10	in	in	ADP
ajlm-2384	143	11	a	a	DET
ajlm-2384	143	12	large	large	ADJ
ajlm-2384	143	13	trna	trna	NOUN
ajlm-2384	143	14	pedigree	pedigree	NOUN
ajlm-2384	143	15	with	with	ADP
ajlm-2384	143	16	maternally	maternally	ADV
ajlm-2384	143	17	transmitted	transmit	VERB
ajlm-2384	143	18	type	type	NOUN
ajlm-2384	143	19	ii	ii	NOUN
ajlm-2384	143	20	diabetes	diabetes	NOUN
ajlm-2384	143	21	mellitus	mellitus	NOUN
ajlm-2384	143	22	and	and	CCONJ
ajlm-2384	143	23	deafness	deafness	NOUN
ajlm-2384	143	24	.	.	PUNCT
ajlm-2384	144	1	nat	nat	PROPN
ajlm-2384	144	2	genet	genet	PROPN
ajlm-2384	144	3	.	.	PUNCT
ajlm-2384	145	1	1992;1:368–371	1992;1:368–371	X
ajlm-2384	145	2	.	.	PROPN
ajlm-2384	145	3	https://doi.org/10.1038/ng0892-368	https://doi.org/10.1038/ng0892-368	PROPN
ajlm-2384	145	4	ng	ng	PROPN
ajlm-2384	145	5	ys	ys	PROPN
ajlm-2384	145	6	,	,	PUNCT
ajlm-2384	145	7	lim	lim	PROPN
ajlm-2384	145	8	az	az	PROPN
ajlm-2384	145	9	,	,	PUNCT
ajlm-2384	145	10	panagiotou	panagiotou	VERB
ajlm-2384	145	11	g	g	PROPN
ajlm-2384	145	12	,	,	PUNCT
ajlm-2384	145	13	turnbull	turnbull	PROPN
ajlm-2384	145	14	dm	dm	PROPN
ajlm-2384	145	15	,	,	PUNCT
ajlm-2384	145	16	walker	walker	PROPN
ajlm-2384	145	17	m.	m.	PROPN
ajlm-2384	145	18	endocrine	endocrine	PROPN
ajlm-2384	145	19	manifestations	manifestation	NOUN
ajlm-2384	145	20	and	and	CCONJ
ajlm-2384	145	21	new	new	ADJ
ajlm-2384	145	22	developments	development	NOUN
ajlm-2384	145	23	in	in	ADP
ajlm-2384	145	24	mitochondrial	mitochondrial	ADJ
ajlm-2384	145	25	disease	disease	NOUN
ajlm-2384	145	26	.	.	PUNCT
ajlm-2384	146	1	endocr	endocr	PROPN
ajlm-2384	146	2	rev	rev	PROPN
ajlm-2384	146	3	.	.	PROPN
ajlm-2384	147	1	2022;43(3	2022;43(3	NUM
ajlm-2384	147	2	):	):	PUNCT
ajlm-2384	147	3	583–609	583–609	NUM
ajlm-2384	147	4	.	.	PUNCT
ajlm-2384	148	1	https://doi.org/10.1210/endrev/bnab036	https://doi.org/10.1210/endrev/bnab036	NOUN
ajlm-2384	148	2	rius	rius	NOUN
ajlm-2384	148	3	r	r	NOUN
ajlm-2384	148	4	,	,	PUNCT
ajlm-2384	148	5	cowley	cowley	PROPN
ajlm-2384	148	6	mj	mj	PROPN
ajlm-2384	148	7	,	,	PUNCT
ajlm-2384	148	8	riley	riley	PROPN
ajlm-2384	148	9	l	l	PROPN
ajlm-2384	148	10	,	,	PUNCT
ajlm-2384	148	11	puttick	puttick	NOUN
ajlm-2384	148	12	c	c	NOUN
ajlm-2384	148	13	,	,	PUNCT
ajlm-2384	148	14	thorburn	thorburn	PROPN
ajlm-2384	148	15	dr	dr	PROPN
ajlm-2384	148	16	,	,	PUNCT
ajlm-2384	148	17	christodoulou	christodoulou	PROPN
ajlm-2384	148	18	j.	j.	PROPN
ajlm-2384	148	19	biparental	biparental	PROPN
ajlm-2384	148	20	inheritance	inheritance	NOUN
ajlm-2384	148	21	of	of	ADP
ajlm-2384	148	22	mitochondrial	mitochondrial	ADJ
ajlm-2384	148	23	dna	dna	NOUN
ajlm-2384	148	24	in	in	ADP
ajlm-2384	148	25	humans	human	NOUN
ajlm-2384	148	26	is	be	AUX
ajlm-2384	148	27	not	not	PART
ajlm-2384	148	28	a	a	DET
ajlm-2384	148	29	common	common	ADJ
ajlm-2384	148	30	phenomenon	phenomenon	NOUN
ajlm-2384	148	31	.	.	PUNCT
ajlm-2384	149	1	genet	genet	PROPN
ajlm-2384	149	2	med	med	PROPN
ajlm-2384	149	3	.	.	PUNCT
ajlm-2384	150	1	2019;21(12):2823–2826	2019;21(12):2823–2826	NUM
ajlm-2384	150	2	.	.	PUNCT
ajlm-2384	150	3	https://doi.org/10.1038/s41436-019-0568-0	https://doi.org/10.1038/s41436-019-0568-0	PROPN
ajlm-2384	150	4	laloi	laloi	PROPN
ajlm-2384	150	5	-	-	PUNCT
ajlm-2384	150	6	michelin	michelin	PROPN
ajlm-2384	150	7	m	m	PROPN
ajlm-2384	150	8	,	,	PUNCT
ajlm-2384	150	9	meas	meas	PROPN
ajlm-2384	150	10	t	t	PROPN
ajlm-2384	150	11	,	,	PUNCT
ajlm-2384	150	12	ambonville	ambonville	PROPN
ajlm-2384	150	13	c	c	AUX
ajlm-2384	150	14	,	,	PUNCT
ajlm-2384	150	15	et	et	PROPN
ajlm-2384	150	16	al	al	PROPN
ajlm-2384	150	17	.	.	PUNCT
ajlm-2384	151	1	the	the	DET
ajlm-2384	151	2	clinical	clinical	ADJ
ajlm-2384	151	3	variability	variability	NOUN
ajlm-2384	151	4	of	of	ADP
ajlm-2384	151	5	maternally	maternally	ADV
ajlm-2384	151	6	inherited	inherit	VERB
ajlm-2384	151	7	diabetes	diabetes	NOUN
ajlm-2384	151	8	and	and	CCONJ
ajlm-2384	151	9	deafness	deafness	NOUN
ajlm-2384	151	10	is	be	AUX
ajlm-2384	151	11	associated	associate	VERB
ajlm-2384	151	12	with	with	ADP
ajlm-2384	151	13	the	the	DET
ajlm-2384	151	14	degree	degree	NOUN
ajlm-2384	151	15	of	of	ADP
ajlm-2384	151	16	heteroplasmy	heteroplasmy	NOUN
ajlm-2384	151	17	in	in	ADP
ajlm-2384	151	18	blood	blood	NOUN
ajlm-2384	151	19	leukocytes	leukocyte	NOUN
ajlm-2384	151	20	.	.	PUNCT
ajlm-2384	152	1	j	j	PROPN
ajlm-2384	152	2	clin	clin	PROPN
ajlm-2384	152	3	endocrinol	endocrinol	PROPN
ajlm-2384	152	4	metab	metab	NOUN
ajlm-2384	152	5	.	.	PUNCT
ajlm-2384	153	1	2009;94(8):3025–3030	2009;94(8):3025–3030	NUM
ajlm-2384	153	2	.	.	PUNCT
ajlm-2384	154	1	https://doi.org/10.1210/jc.2008-2680	https://doi.org/10.1210/jc.2008-2680	PROPN
ajlm-2384	154	2	urata	urata	PROPN
ajlm-2384	154	3	m	m	PROPN
ajlm-2384	154	4	,	,	PUNCT
ajlm-2384	154	5	wakiyama	wakiyama	PROPN
ajlm-2384	154	6	m	m	PROPN
ajlm-2384	154	7	,	,	PUNCT
ajlm-2384	154	8	iwase	iwase	PROPN
ajlm-2384	154	9	m	m	PROPN
ajlm-2384	154	10	,	,	PUNCT
ajlm-2384	154	11	et	et	PROPN
ajlm-2384	154	12	al	al	PROPN
ajlm-2384	154	13	.	.	PUNCT
ajlm-2384	155	1	new	new	ADJ
ajlm-2384	155	2	sensitive	sensitive	ADJ
ajlm-2384	155	3	method	method	NOUN
ajlm-2384	155	4	for	for	ADP
ajlm-2384	155	5	the	the	DET
ajlm-2384	155	6	detection	detection	NOUN
ajlm-2384	155	7	of	of	ADP
ajlm-2384	155	8	the	the	DET
ajlm-2384	155	9	a3243	a3243	PROPN
ajlm-2384	155	10	g	g	NOUN
ajlm-2384	155	11	mutation	mutation	NOUN
ajlm-2384	155	12	of	of	ADP
ajlm-2384	155	13	human	human	ADJ
ajlm-2384	155	14	mitochondrial	mitochondrial	ADJ
ajlm-2384	155	15	deoxyribonucleic	deoxyribonucleic	ADJ
ajlm-2384	155	16	acid	acid	NOUN
ajlm-2384	155	17	in	in	ADP
ajlm-2384	155	18	diabetes	diabetes	NOUN
ajlm-2384	155	19	mellitus	mellitus	NOUN
ajlm-2384	155	20	patients	patient	NOUN
ajlm-2384	155	21	by	by	ADP
ajlm-2384	155	22	ligation	ligation	NOUN
ajlm-2384	155	23	-	-	PUNCT
ajlm-2384	155	24	mediated	mediate	VERB
ajlm-2384	155	25	polymerase	polymerase	NOUN
ajlm-2384	155	26	chain	chain	NOUN
ajlm-2384	155	27	reaction	reaction	NOUN
ajlm-2384	155	28	.	.	PUNCT
ajlm-2384	156	1	clin	clin	PROPN
ajlm-2384	156	2	chem	chem	PROPN
ajlm-2384	156	3	.	.	PUNCT
ajlm-2384	157	1	1998;44(10):2088–2093	1998;44(10):2088–2093	NUM
ajlm-2384	157	2	.	.	PUNCT
ajlm-2384	158	1	https://doi.org/10.1093/clinchem/44.10.2088	https://doi.org/10.1093/clinchem/44.10.2088	PROPN
ajlm-2384	159	1	müller	müller	PROPN
ajlm-2384	159	2	pl	pl	PROPN
ajlm-2384	159	3	,	,	PUNCT
ajlm-2384	159	4	treis	treis	PROPN
ajlm-2384	159	5	t	t	PROPN
ajlm-2384	159	6	,	,	PUNCT
ajlm-2384	159	7	pfau	pfau	NOUN
ajlm-2384	159	8	m	m	PROPN
ajlm-2384	159	9	,	,	PUNCT
ajlm-2384	159	10	et	et	PROPN
ajlm-2384	159	11	al	al	PROPN
ajlm-2384	159	12	.	.	PUNCT
ajlm-2384	159	13	progression	progression	NOUN
ajlm-2384	159	14	of	of	ADP
ajlm-2384	159	15	retinopathy	retinopathy	ADJ
ajlm-2384	159	16	secondary	secondary	ADJ
ajlm-2384	159	17	to	to	ADP
ajlm-2384	159	18	maternally	maternally	ADV
ajlm-2384	159	19	inherited	inherit	VERB
ajlm-2384	159	20	diabetes	diabetes	NOUN
ajlm-2384	159	21	and	and	CCONJ
ajlm-2384	159	22	deafness	deafness	NOUN
ajlm-2384	159	23	–	–	PUNCT
ajlm-2384	159	24	evaluation	evaluation	NOUN
ajlm-2384	159	25	of	of	ADP
ajlm-2384	159	26	predicting	predict	VERB
ajlm-2384	159	27	parameters	parameter	NOUN
ajlm-2384	159	28	.	.	PUNCT
ajlm-2384	160	1	am	be	AUX
ajlm-2384	160	2	j	j	PROPN
ajlm-2384	160	3	ophthalmol	ophthalmol	NOUN
ajlm-2384	160	4	.	.	PUNCT
ajlm-2384	161	1	2020;213:134–144	2020;213:134–144	NUM
ajlm-2384	161	2	.	.	PUNCT
ajlm-2384	162	1	https://doi.org/10.1016/j.ajo.2020.01.013	https://doi.org/10.1016/j.ajo.2020.01.013	NOUN