id	sid	tid	token	lemma	pos
ajlm-463	1	1	abstract	abstract	ADJ
ajlm-463	1	2	introduction	introduction	NOUN
ajlm-463	1	3	methods	method	NOUN
ajlm-463	1	4	results	result	VERB
ajlm-463	1	5	discussion	discussion	NOUN
ajlm-463	1	6	acknowledgements	acknowledgement	NOUN
ajlm-463	1	7	references	reference	NOUN
ajlm-463	1	8	about	about	ADP
ajlm-463	1	9	the	the	DET
ajlm-463	1	10	author(s	author(s	NOUN
ajlm-463	1	11	)	)	PUNCT
ajlm-463	1	12	tarsizio	tarsizio	PROPN
ajlm-463	1	13	chikaonda	chikaonda	PROPN
ajlm-463	1	14	department	department	PROPN
ajlm-463	1	15	of	of	ADP
ajlm-463	1	16	molecular	molecular	ADJ
ajlm-463	1	17	medicine	medicine	NOUN
ajlm-463	1	18	and	and	CCONJ
ajlm-463	1	19	haematology	haematology	NOUN
ajlm-463	1	20	,	,	PUNCT
ajlm-463	1	21	faculty	faculty	NOUN
ajlm-463	1	22	of	of	ADP
ajlm-463	1	23	health	health	NOUN
ajlm-463	1	24	sciences	sciences	PROPN
ajlm-463	1	25	,	,	PUNCT
ajlm-463	1	26	school	school	NOUN
ajlm-463	1	27	of	of	ADP
ajlm-463	1	28	pathology	pathology	PROPN
ajlm-463	1	29	,	,	PUNCT
ajlm-463	1	30	university	university	NOUN
ajlm-463	1	31	of	of	ADP
ajlm-463	1	32	the	the	DET
ajlm-463	1	33	witwatersrand	witwatersrand	NOUN
ajlm-463	1	34	,	,	PUNCT
ajlm-463	1	35	johannesburg	johannesburg	PROPN
ajlm-463	1	36	,	,	PUNCT
ajlm-463	1	37	south	south	PROPN
ajlm-463	1	38	africa	africa	PROPN
ajlm-463	1	39	unc	unc	PROPN
ajlm-463	1	40	project	project	PROPN
ajlm-463	1	41	,	,	PUNCT
ajlm-463	1	42	lilongwe	lilongwe	PROPN
ajlm-463	1	43	,	,	PUNCT
ajlm-463	1	44	malawi	malawi	PROPN
ajlm-463	1	45	irene	irene	PROPN
ajlm-463	1	46	ketseoglou	ketseoglou	PROPN
ajlm-463	1	47	department	department	PROPN
ajlm-463	1	48	of	of	ADP
ajlm-463	1	49	molecular	molecular	ADJ
ajlm-463	1	50	medicine	medicine	NOUN
ajlm-463	1	51	and	and	CCONJ
ajlm-463	1	52	haematology	haematology	NOUN
ajlm-463	1	53	,	,	PUNCT
ajlm-463	1	54	faculty	faculty	NOUN
ajlm-463	1	55	of	of	ADP
ajlm-463	1	56	health	health	NOUN
ajlm-463	1	57	sciences	sciences	PROPN
ajlm-463	1	58	,	,	PUNCT
ajlm-463	1	59	school	school	NOUN
ajlm-463	1	60	of	of	ADP
ajlm-463	1	61	pathology	pathology	PROPN
ajlm-463	1	62	,	,	PUNCT
ajlm-463	1	63	university	university	NOUN
ajlm-463	1	64	of	of	ADP
ajlm-463	1	65	the	the	DET
ajlm-463	1	66	witwatersrand	witwatersrand	NOUN
ajlm-463	1	67	,	,	PUNCT
ajlm-463	1	68	johannesburg	johannesburg	PROPN
ajlm-463	1	69	,	,	PUNCT
ajlm-463	1	70	south	south	PROPN
ajlm-463	1	71	africa	africa	PROPN
ajlm-463	1	72	nelson	nelson	PROPN
ajlm-463	1	73	nguluwe	nguluwe	PROPN
ajlm-463	1	74	unc	unc	PROPN
ajlm-463	1	75	project	project	PROPN
ajlm-463	1	76	,	,	PUNCT
ajlm-463	1	77	lilongwe	lilongwe	PROPN
ajlm-463	1	78	,	,	PUNCT
ajlm-463	1	79	malawi	malawi	PROPN
ajlm-463	1	80	robert	robert	PROPN
ajlm-463	1	81	krysiak	krysiak	PROPN
ajlm-463	1	82	unc	unc	PROPN
ajlm-463	1	83	project	project	PROPN
ajlm-463	1	84	,	,	PUNCT
ajlm-463	1	85	lilongwe	lilongwe	PROPN
ajlm-463	1	86	,	,	PUNCT
ajlm-463	1	87	malawi	malawi	PROPN
ajlm-463	1	88	isaac	isaac	PROPN
ajlm-463	1	89	thengolose	thengolose	PROPN
ajlm-463	1	90	unc	unc	PROPN
ajlm-463	1	91	project	project	PROPN
ajlm-463	1	92	,	,	PUNCT
ajlm-463	1	93	lilongwe	lilongwe	PROPN
ajlm-463	1	94	,	,	PUNCT
ajlm-463	1	95	malawi	malawi	PROPN
ajlm-463	2	1	felix	felix	PROPN
ajlm-463	2	2	nyakwawa	nyakwawa	PROPN
ajlm-463	2	3	malawi	malawi	PROPN
ajlm-463	2	4	national	national	ADJ
ajlm-463	2	5	tuberculosis	tuberculosis	NOUN
ajlm-463	2	6	programme	programme	NOUN
ajlm-463	2	7	,	,	PUNCT
ajlm-463	2	8	lilongwe	lilongwe	PROPN
ajlm-463	2	9	,	,	PUNCT
ajlm-463	2	10	malawi	malawi	PROPN
ajlm-463	2	11	nora	nora	PROPN
ajlm-463	2	12	e.	e.	PROPN
ajlm-463	2	13	rosenberg	rosenberg	PROPN
ajlm-463	2	14	unc	unc	PROPN
ajlm-463	2	15	project	project	PROPN
ajlm-463	2	16	,	,	PUNCT
ajlm-463	2	17	lilongwe	lilongwe	PROPN
ajlm-463	2	18	,	,	PUNCT
ajlm-463	2	19	malawi	malawi	PROPN
ajlm-463	2	20	christopher	christopher	PROPN
ajlm-463	2	21	stanley	stanley	PROPN
ajlm-463	2	22	unc	unc	PROPN
ajlm-463	2	23	project	project	PROPN
ajlm-463	2	24	,	,	PUNCT
ajlm-463	2	25	lilongwe	lilongwe	PROPN
ajlm-463	2	26	,	,	PUNCT
ajlm-463	2	27	malawi	malawi	PROPN
ajlm-463	2	28	james	james	PROPN
ajlm-463	2	29	mpunga	mpunga	PROPN
ajlm-463	2	30	malawi	malawi	PROPN
ajlm-463	2	31	national	national	ADJ
ajlm-463	2	32	tuberculosis	tuberculosis	NOUN
ajlm-463	2	33	programme	programme	NOUN
ajlm-463	2	34	,	,	PUNCT
ajlm-463	2	35	lilongwe	lilongwe	PROPN
ajlm-463	2	36	,	,	PUNCT
ajlm-463	2	37	malawi	malawi	PROPN
ajlm-463	2	38	irving	irving	PROPN
ajlm-463	2	39	f.	f.	PROPN
ajlm-463	2	40	hoffman	hoffman	PROPN
ajlm-463	2	41	unc	unc	PROPN
ajlm-463	2	42	project	project	PROPN
ajlm-463	2	43	,	,	PUNCT
ajlm-463	2	44	lilongwe	lilongwe	PROPN
ajlm-463	2	45	,	,	PUNCT
ajlm-463	2	46	malawi	malawi	PROPN
ajlm-463	2	47	university	university	PROPN
ajlm-463	2	48	of	of	ADP
ajlm-463	2	49	north	north	PROPN
ajlm-463	2	50	carolina	carolina	PROPN
ajlm-463	2	51	at	at	ADP
ajlm-463	2	52	chapel	chapel	PROPN
ajlm-463	2	53	hill	hill	PROPN
ajlm-463	2	54	,	,	PUNCT
ajlm-463	2	55	chapel	chapel	NOUN
ajlm-463	2	56	hill	hill	PROPN
ajlm-463	2	57	,	,	PUNCT
ajlm-463	2	58	north	north	PROPN
ajlm-463	2	59	carolina	carolina	PROPN
ajlm-463	2	60	,	,	PUNCT
ajlm-463	2	61	united	united	PROPN
ajlm-463	2	62	states	states	PROPN
ajlm-463	2	63	maria	maria	PROPN
ajlm-463	2	64	a.	a.	PROPN
ajlm-463	2	65	papathanasopoulos	papathanasopoulos	PROPN
ajlm-463	2	66	department	department	PROPN
ajlm-463	2	67	of	of	ADP
ajlm-463	2	68	molecular	molecular	ADJ
ajlm-463	2	69	medicine	medicine	NOUN
ajlm-463	2	70	and	and	CCONJ
ajlm-463	2	71	haematology	haematology	NOUN
ajlm-463	2	72	,	,	PUNCT
ajlm-463	2	73	faculty	faculty	NOUN
ajlm-463	2	74	of	of	ADP
ajlm-463	2	75	health	health	NOUN
ajlm-463	2	76	sciences	sciences	PROPN
ajlm-463	2	77	,	,	PUNCT
ajlm-463	2	78	school	school	NOUN
ajlm-463	2	79	of	of	ADP
ajlm-463	2	80	pathology	pathology	PROPN
ajlm-463	2	81	,	,	PUNCT
ajlm-463	2	82	university	university	NOUN
ajlm-463	2	83	of	of	ADP
ajlm-463	2	84	the	the	DET
ajlm-463	2	85	witwatersrand	witwatersrand	NOUN
ajlm-463	2	86	,	,	PUNCT
ajlm-463	2	87	johannesburg	johannesburg	PROPN
ajlm-463	2	88	,	,	PUNCT
ajlm-463	2	89	south	south	PROPN
ajlm-463	2	90	africa	africa	PROPN
ajlm-463	2	91	mina	mina	PROPN
ajlm-463	2	92	hosseinipour	hosseinipour	PROPN
ajlm-463	2	93	unc	unc	PROPN
ajlm-463	2	94	project	project	PROPN
ajlm-463	2	95	,	,	PUNCT
ajlm-463	2	96	lilongwe	lilongwe	PROPN
ajlm-463	2	97	,	,	PUNCT
ajlm-463	2	98	malawi	malawi	PROPN
ajlm-463	2	99	university	university	PROPN
ajlm-463	2	100	of	of	ADP
ajlm-463	2	101	north	north	PROPN
ajlm-463	2	102	carolina	carolina	PROPN
ajlm-463	2	103	at	at	ADP
ajlm-463	2	104	chapel	chapel	PROPN
ajlm-463	2	105	hill	hill	PROPN
ajlm-463	2	106	,	,	PUNCT
ajlm-463	2	107	chapel	chapel	NOUN
ajlm-463	2	108	hill	hill	PROPN
ajlm-463	2	109	,	,	PUNCT
ajlm-463	2	110	north	north	PROPN
ajlm-463	2	111	carolina	carolina	PROPN
ajlm-463	2	112	,	,	PUNCT
ajlm-463	2	113	united	united	PROPN
ajlm-463	2	114	states	states	PROPN
ajlm-463	2	115	lesley	lesley	PROPN
ajlm-463	2	116	scott	scott	PROPN
ajlm-463	2	117	department	department	PROPN
ajlm-463	2	118	of	of	ADP
ajlm-463	2	119	molecular	molecular	ADJ
ajlm-463	2	120	medicine	medicine	NOUN
ajlm-463	2	121	and	and	CCONJ
ajlm-463	2	122	haematology	haematology	NOUN
ajlm-463	2	123	,	,	PUNCT
ajlm-463	2	124	faculty	faculty	NOUN
ajlm-463	2	125	of	of	ADP
ajlm-463	2	126	health	health	NOUN
ajlm-463	2	127	sciences	sciences	PROPN
ajlm-463	2	128	,	,	PUNCT
ajlm-463	2	129	school	school	NOUN
ajlm-463	2	130	of	of	ADP
ajlm-463	2	131	pathology	pathology	PROPN
ajlm-463	2	132	,	,	PUNCT
ajlm-463	2	133	university	university	NOUN
ajlm-463	2	134	of	of	ADP
ajlm-463	2	135	the	the	DET
ajlm-463	2	136	witwatersrand	witwatersrand	NOUN
ajlm-463	2	137	,	,	PUNCT
ajlm-463	2	138	johannesburg	johannesburg	PROPN
ajlm-463	2	139	,	,	PUNCT
ajlm-463	2	140	south	south	PROPN
ajlm-463	2	141	africa	africa	PROPN
ajlm-463	2	142	wendy	wendy	PROPN
ajlm-463	2	143	stevens	stevens	PROPN
ajlm-463	2	144	department	department	PROPN
ajlm-463	2	145	of	of	ADP
ajlm-463	2	146	molecular	molecular	ADJ
ajlm-463	2	147	medicine	medicine	NOUN
ajlm-463	2	148	and	and	CCONJ
ajlm-463	2	149	haematology	haematology	NOUN
ajlm-463	2	150	,	,	PUNCT
ajlm-463	2	151	faculty	faculty	NOUN
ajlm-463	2	152	of	of	ADP
ajlm-463	2	153	health	health	NOUN
ajlm-463	2	154	sciences	sciences	PROPN
ajlm-463	2	155	,	,	PUNCT
ajlm-463	2	156	school	school	NOUN
ajlm-463	2	157	of	of	ADP
ajlm-463	2	158	pathology	pathology	PROPN
ajlm-463	2	159	,	,	PUNCT
ajlm-463	2	160	university	university	NOUN
ajlm-463	2	161	of	of	ADP
ajlm-463	2	162	the	the	DET
ajlm-463	2	163	witwatersrand	witwatersrand	NOUN
ajlm-463	2	164	,	,	PUNCT
ajlm-463	2	165	johannesburg	johannesburg	PROPN
ajlm-463	2	166	,	,	PUNCT
ajlm-463	2	167	south	south	PROPN
ajlm-463	2	168	africa	africa	PROPN
ajlm-463	2	169	citation	citation	PROPN
ajlm-463	2	170	chikaonda	chikaonda	PROPN
ajlm-463	2	171	t	t	PROPN
ajlm-463	2	172	,	,	PUNCT
ajlm-463	2	173	ketseoglou	ketseoglou	PROPN
ajlm-463	2	174	i	i	PROPN
ajlm-463	2	175	,	,	PUNCT
ajlm-463	2	176	nguluwe	nguluwe	NOUN
ajlm-463	2	177	n	n	CCONJ
ajlm-463	2	178	,	,	PUNCT
ajlm-463	2	179	et	et	PROPN
ajlm-463	2	180	al	al	PROPN
ajlm-463	2	181	.	.	PUNCT
ajlm-463	3	1	molecular	molecular	ADJ
ajlm-463	3	2	characterisation	characterisation	NOUN
ajlm-463	3	3	of	of	ADP
ajlm-463	3	4	rifampicin	rifampicin	VERB
ajlm-463	3	5	-	-	PUNCT
ajlm-463	3	6	resistant	resistant	ADJ
ajlm-463	3	7	mycobacterium	mycobacterium	NOUN
ajlm-463	3	8	tuberculosis	tuberculosis	NOUN
ajlm-463	3	9	strains	strain	NOUN
ajlm-463	3	10	from	from	ADP
ajlm-463	3	11	malawi	malawi	PROPN
ajlm-463	3	12	.	.	PUNCT
ajlm-463	4	1	afr	afr	PROPN
ajlm-463	4	2	j	j	PROPN
ajlm-463	4	3	lab	lab	PROPN
ajlm-463	4	4	med	med	PROPN
ajlm-463	4	5	.	.	PUNCT
ajlm-463	5	1	2017;6(2	2017;6(2	NUM
ajlm-463	5	2	)	)	PUNCT
ajlm-463	5	3	,	,	PUNCT
ajlm-463	5	4	a463	a463	PROPN
ajlm-463	5	5	.	.	PUNCT
ajlm-463	5	6	https://doi.org/10.4102/ajlm.v6i2.463	https://doi.org/10.4102/ajlm.v6i2.463	PROPN
ajlm-463	5	7	original	original	ADJ
ajlm-463	5	8	research	research	NOUN
ajlm-463	5	9	molecular	molecular	ADJ
ajlm-463	5	10	characterisation	characterisation	NOUN
ajlm-463	5	11	of	of	ADP
ajlm-463	5	12	rifampicin	rifampicin	VERB
ajlm-463	5	13	-	-	PUNCT
ajlm-463	5	14	resistant	resistant	ADJ
ajlm-463	5	15	mycobacterium	mycobacterium	NOUN
ajlm-463	5	16	tuberculosis	tuberculosis	NOUN
ajlm-463	5	17	strains	strain	NOUN
ajlm-463	5	18	from	from	ADP
ajlm-463	5	19	malawi	malawi	PROPN
ajlm-463	5	20	tarsizio	tarsizio	PROPN
ajlm-463	5	21	chikaonda	chikaonda	PROPN
ajlm-463	5	22	,	,	PUNCT
ajlm-463	5	23	irene	irene	PROPN
ajlm-463	5	24	ketseoglou	ketseoglou	PROPN
ajlm-463	5	25	,	,	PUNCT
ajlm-463	5	26	nelson	nelson	PROPN
ajlm-463	5	27	nguluwe	nguluwe	PROPN
ajlm-463	5	28	,	,	PUNCT
ajlm-463	5	29	robert	robert	PROPN
ajlm-463	5	30	krysiak	krysiak	PROPN
ajlm-463	5	31	,	,	PUNCT
ajlm-463	5	32	isaac	isaac	PROPN
ajlm-463	5	33	thengolose	thengolose	PROPN
ajlm-463	5	34	,	,	PUNCT
ajlm-463	5	35	felix	felix	PROPN
ajlm-463	5	36	nyakwawa	nyakwawa	PROPN
ajlm-463	5	37	,	,	PUNCT
ajlm-463	5	38	nora	nora	PROPN
ajlm-463	5	39	e.	e.	PROPN
ajlm-463	5	40	rosenberg	rosenberg	PROPN
ajlm-463	5	41	,	,	PUNCT
ajlm-463	5	42	christopher	christopher	PROPN
ajlm-463	5	43	stanley	stanley	PROPN
ajlm-463	5	44	,	,	PUNCT
ajlm-463	5	45	james	james	PROPN
ajlm-463	5	46	mpunga	mpunga	PROPN
ajlm-463	5	47	,	,	PUNCT
ajlm-463	5	48	irving	irving	PROPN
ajlm-463	5	49	f.	f.	PROPN
ajlm-463	5	50	hoffman	hoffman	PROPN
ajlm-463	5	51	,	,	PUNCT
ajlm-463	5	52	maria	maria	PROPN
ajlm-463	5	53	a.	a.	PROPN
ajlm-463	5	54	papathanasopoulos	papathanasopoulos	PROPN
ajlm-463	5	55	,	,	PUNCT
ajlm-463	5	56	mina	mina	PROPN
ajlm-463	5	57	hosseinipour	hosseinipour	PROPN
ajlm-463	5	58	,	,	PUNCT
ajlm-463	5	59	lesley	lesley	PROPN
ajlm-463	5	60	scott	scott	PROPN
ajlm-463	5	61	,	,	PUNCT
ajlm-463	5	62	wendy	wendy	PROPN
ajlm-463	5	63	stevens	stevens	PROPN
ajlm-463	5	64	received	receive	VERB
ajlm-463	5	65	:	:	PUNCT
ajlm-463	5	66	08	08	NUM
ajlm-463	5	67	apr	apr	NOUN
ajlm-463	5	68	.	.	PROPN
ajlm-463	5	69	2016	2016	NUM
ajlm-463	5	70	;	;	PUNCT
ajlm-463	5	71	accepted	accept	VERB
ajlm-463	5	72	:	:	PUNCT
ajlm-463	5	73	05	05	NUM
ajlm-463	5	74	oct	oct	PROPN
ajlm-463	5	75	.	.	PROPN
ajlm-463	5	76	2016	2016	NUM
ajlm-463	5	77	;	;	PUNCT
ajlm-463	5	78	published	publish	VERB
ajlm-463	5	79	:	:	PUNCT
ajlm-463	5	80	31	31	NUM
ajlm-463	5	81	mar	mar	PROPN
ajlm-463	5	82	.	.	PROPN
ajlm-463	6	1	2017	2017	NUM
ajlm-463	6	2	copyright	copyright	NOUN
ajlm-463	6	3	:	:	PUNCT
ajlm-463	6	4	©	©	PROPN
ajlm-463	6	5	2017	2017	NUM
ajlm-463	6	6	.	.	PUNCT
ajlm-463	7	1	the	the	DET
ajlm-463	7	2	author(s	author(s	PROPN
ajlm-463	7	3	)	)	PUNCT
ajlm-463	7	4	.	.	PUNCT
ajlm-463	8	1	licensee	licensee	NOUN
ajlm-463	8	2	:	:	PUNCT
ajlm-463	8	3	aosis	aosis	NOUN
ajlm-463	8	4	.	.	PUNCT
ajlm-463	9	1	this	this	PRON
ajlm-463	9	2	is	be	AUX
ajlm-463	9	3	an	an	DET
ajlm-463	9	4	open	open	ADJ
ajlm-463	9	5	access	access	NOUN
ajlm-463	9	6	article	article	NOUN
ajlm-463	9	7	distributed	distribute	VERB
ajlm-463	9	8	under	under	ADP
ajlm-463	9	9	the	the	DET
ajlm-463	9	10	terms	term	NOUN
ajlm-463	9	11	of	of	ADP
ajlm-463	9	12	the	the	DET
ajlm-463	9	13	creative	creative	ADJ
ajlm-463	9	14	commons	common	NOUN
ajlm-463	9	15	attribution	attribution	NOUN
ajlm-463	9	16	license	license	NOUN
ajlm-463	9	17	,	,	PUNCT
ajlm-463	9	18	which	which	PRON
ajlm-463	9	19	permits	permit	VERB
ajlm-463	9	20	unrestricted	unrestricted	ADJ
ajlm-463	9	21	use	use	NOUN
ajlm-463	9	22	,	,	PUNCT
ajlm-463	9	23	distribution	distribution	NOUN
ajlm-463	9	24	,	,	PUNCT
ajlm-463	9	25	and	and	CCONJ
ajlm-463	9	26	reproduction	reproduction	NOUN
ajlm-463	9	27	in	in	ADP
ajlm-463	9	28	any	any	DET
ajlm-463	9	29	medium	medium	NOUN
ajlm-463	9	30	,	,	PUNCT
ajlm-463	9	31	provided	provide	VERB
ajlm-463	9	32	the	the	DET
ajlm-463	9	33	original	original	ADJ
ajlm-463	9	34	work	work	NOUN
ajlm-463	9	35	is	be	AUX
ajlm-463	9	36	properly	properly	ADV
ajlm-463	9	37	cited	cite	VERB
ajlm-463	9	38	.	.	PUNCT
ajlm-463	10	1	abstract	abstract	ADJ
ajlm-463	10	2	background	background	NOUN
ajlm-463	10	3	:	:	PUNCT
ajlm-463	10	4	availability	availability	NOUN
ajlm-463	10	5	and	and	CCONJ
ajlm-463	10	6	access	access	NOUN
ajlm-463	10	7	to	to	ADP
ajlm-463	10	8	the	the	DET
ajlm-463	10	9	detection	detection	NOUN
ajlm-463	10	10	of	of	ADP
ajlm-463	10	11	resistance	resistance	NOUN
ajlm-463	10	12	to	to	ADP
ajlm-463	10	13	anti	anti	ADJ
ajlm-463	10	14	-	-	ADJ
ajlm-463	10	15	tuberculosis	tuberculosis	ADJ
ajlm-463	10	16	drugs	drug	NOUN
ajlm-463	10	17	remains	remain	VERB
ajlm-463	10	18	a	a	DET
ajlm-463	10	19	significant	significant	ADJ
ajlm-463	10	20	challenge	challenge	NOUN
ajlm-463	10	21	in	in	ADP
ajlm-463	10	22	malawi	malawi	PROPN
ajlm-463	10	23	due	due	ADP
ajlm-463	10	24	to	to	ADP
ajlm-463	10	25	limited	limited	ADJ
ajlm-463	10	26	diagnostic	diagnostic	ADJ
ajlm-463	10	27	services	service	NOUN
ajlm-463	10	28	.	.	PUNCT
ajlm-463	11	1	the	the	DET
ajlm-463	11	2	xpert	xpert	PROPN
ajlm-463	11	3	®	®	PROPN
ajlm-463	11	4	mtb	mtb	PROPN
ajlm-463	11	5	/	/	SYM
ajlm-463	11	6	rif	rif	PROPN
ajlm-463	11	7	can	can	AUX
ajlm-463	11	8	detect	detect	VERB
ajlm-463	11	9	mycobacterium	mycobacterium	NOUN
ajlm-463	11	10	tuberculosis	tuberculosis	NOUN
ajlm-463	11	11	and	and	CCONJ
ajlm-463	11	12	resistance	resistance	NOUN
ajlm-463	11	13	to	to	ADP
ajlm-463	11	14	rifampicin	rifampicin	VERB
ajlm-463	11	15	in	in	ADP
ajlm-463	11	16	a	a	DET
ajlm-463	11	17	single	single	ADJ
ajlm-463	11	18	,	,	PUNCT
ajlm-463	11	19	rapid	rapid	ADJ
ajlm-463	11	20	assay	assay	NOUN
ajlm-463	11	21	.	.	PUNCT
ajlm-463	12	1	rifampicin	rifampicin	VERB
ajlm-463	12	2	-	-	PUNCT
ajlm-463	12	3	resistant	resistant	ADJ
ajlm-463	12	4	m.	m.	NOUN
ajlm-463	12	5	tuberculosis	tuberculosis	NOUN
ajlm-463	12	6	has	have	AUX
ajlm-463	12	7	not	not	PART
ajlm-463	12	8	been	be	AUX
ajlm-463	12	9	well	well	ADV
ajlm-463	12	10	studied	study	VERB
ajlm-463	12	11	in	in	ADP
ajlm-463	12	12	malawi	malawi	PROPN
ajlm-463	12	13	.	.	PUNCT
ajlm-463	13	1	objectives	objective	NOUN
ajlm-463	13	2	:	:	PUNCT
ajlm-463	13	3	we	we	PRON
ajlm-463	13	4	aimed	aim	VERB
ajlm-463	13	5	to	to	PART
ajlm-463	13	6	determine	determine	VERB
ajlm-463	13	7	mutations	mutation	NOUN
ajlm-463	13	8	in	in	ADP
ajlm-463	13	9	the	the	DET
ajlm-463	13	10	rifampicin	rifampicin	VERB
ajlm-463	13	11	resistance	resistance	NOUN
ajlm-463	13	12	determining	determine	VERB
ajlm-463	13	13	region	region	NOUN
ajlm-463	13	14	(	(	PUNCT
ajlm-463	13	15	rrdr	rrdr	PROPN
ajlm-463	13	16	)	)	PUNCT
ajlm-463	13	17	of	of	ADP
ajlm-463	13	18	the	the	DET
ajlm-463	13	19	rpob	rpob	ADJ
ajlm-463	13	20	gene	gene	NOUN
ajlm-463	13	21	of	of	ADP
ajlm-463	13	22	m.	m.	NOUN
ajlm-463	13	23	tuberculosis	tuberculosis	NOUN
ajlm-463	13	24	strains	strain	NOUN
ajlm-463	13	25	which	which	PRON
ajlm-463	13	26	were	be	AUX
ajlm-463	13	27	defined	define	VERB
ajlm-463	13	28	as	as	ADP
ajlm-463	13	29	resistant	resistant	ADJ
ajlm-463	13	30	to	to	ADP
ajlm-463	13	31	rifampicin	rifampicin	VERB
ajlm-463	13	32	by	by	ADP
ajlm-463	13	33	the	the	DET
ajlm-463	13	34	xpert	xpert	PROPN
ajlm-463	13	35	mtb	mtb	PROPN
ajlm-463	13	36	/	/	SYM
ajlm-463	13	37	rif	rif	PROPN
ajlm-463	13	38	assay	assay	PROPN
ajlm-463	13	39	.	.	PUNCT
ajlm-463	14	1	methods	method	NOUN
ajlm-463	14	2	:	:	PUNCT
ajlm-463	14	3	rifampicin	rifampicin	VERB
ajlm-463	14	4	-	-	PUNCT
ajlm-463	14	5	resistant	resistant	ADJ
ajlm-463	14	6	isolates	isolate	NOUN
ajlm-463	14	7	from	from	ADP
ajlm-463	14	8	43	43	NUM
ajlm-463	14	9	adult	adult	NOUN
ajlm-463	14	10	patients	patient	NOUN
ajlm-463	14	11	(	(	PUNCT
ajlm-463	14	12	≥	≥	NOUN
ajlm-463	14	13	18	18	NUM
ajlm-463	14	14	years	year	NOUN
ajlm-463	14	15	)	)	PUNCT
ajlm-463	14	16	from	from	ADP
ajlm-463	14	17	various	various	ADJ
ajlm-463	14	18	districts	district	NOUN
ajlm-463	14	19	of	of	ADP
ajlm-463	14	20	malawi	malawi	PROPN
ajlm-463	14	21	were	be	AUX
ajlm-463	14	22	characterised	characterise	VERB
ajlm-463	14	23	for	for	ADP
ajlm-463	14	24	mutations	mutation	NOUN
ajlm-463	14	25	in	in	ADP
ajlm-463	14	26	the	the	DET
ajlm-463	14	27	rrdr	rrdr	NOUN
ajlm-463	14	28	(	(	PUNCT
ajlm-463	14	29	codons	codon	NOUN
ajlm-463	14	30	507–533	507–533	NUM
ajlm-463	14	31	)	)	PUNCT
ajlm-463	14	32	of	of	ADP
ajlm-463	14	33	the	the	DET
ajlm-463	14	34	rpob	rpob	ADJ
ajlm-463	14	35	gene	gene	NOUN
ajlm-463	14	36	by	by	ADP
ajlm-463	14	37	dna	dna	PROPN
ajlm-463	14	38	sequencing	sequencing	NOUN
ajlm-463	14	39	.	.	PUNCT
ajlm-463	15	1	results	result	NOUN
ajlm-463	15	2	:	:	PUNCT
ajlm-463	15	3	mutations	mutation	NOUN
ajlm-463	15	4	were	be	AUX
ajlm-463	15	5	found	find	VERB
ajlm-463	15	6	in	in	ADP
ajlm-463	15	7	37/43	37/43	NUM
ajlm-463	15	8	(	(	PUNCT
ajlm-463	15	9	86	86	NUM
ajlm-463	15	10	%	%	NOUN
ajlm-463	15	11	)	)	PUNCT
ajlm-463	15	12	of	of	ADP
ajlm-463	15	13	the	the	DET
ajlm-463	15	14	resistant	resistant	ADJ
ajlm-463	15	15	isolates	isolate	NOUN
ajlm-463	15	16	in	in	ADP
ajlm-463	15	17	codons	codon	NOUN
ajlm-463	15	18	511	511	NUM
ajlm-463	15	19	,	,	PUNCT
ajlm-463	15	20	512	512	NUM
ajlm-463	15	21	,	,	PUNCT
ajlm-463	15	22	513	513	NUM
ajlm-463	15	23	,	,	PUNCT
ajlm-463	15	24	516	516	NUM
ajlm-463	15	25	,	,	PUNCT
ajlm-463	15	26	522	522	NUM
ajlm-463	15	27	,	,	PUNCT
ajlm-463	15	28	526	526	NUM
ajlm-463	15	29	and	and	CCONJ
ajlm-463	15	30	531	531	NUM
ajlm-463	15	31	.	.	PUNCT
ajlm-463	16	1	the	the	DET
ajlm-463	16	2	most	most	ADV
ajlm-463	16	3	common	common	ADJ
ajlm-463	16	4	mutations	mutation	NOUN
ajlm-463	16	5	were	be	AUX
ajlm-463	16	6	in	in	ADP
ajlm-463	16	7	codons	codon	NOUN
ajlm-463	16	8	526	526	NUM
ajlm-463	16	9	(	(	PUNCT
ajlm-463	16	10	38	38	NUM
ajlm-463	16	11	%	%	NOUN
ajlm-463	16	12	)	)	PUNCT
ajlm-463	16	13	,	,	PUNCT
ajlm-463	16	14	531	531	NUM
ajlm-463	16	15	(	(	PUNCT
ajlm-463	16	16	29.7	29.7	NUM
ajlm-463	16	17	%	%	NOUN
ajlm-463	16	18	)	)	PUNCT
ajlm-463	16	19	and	and	CCONJ
ajlm-463	16	20	516	516	NUM
ajlm-463	16	21	(	(	PUNCT
ajlm-463	16	22	16.2	16.2	NUM
ajlm-463	16	23	%	%	NOUN
ajlm-463	16	24	)	)	PUNCT
ajlm-463	16	25	.	.	PUNCT
ajlm-463	17	1	mutations	mutation	NOUN
ajlm-463	17	2	were	be	AUX
ajlm-463	17	3	not	not	PART
ajlm-463	17	4	found	find	VERB
ajlm-463	17	5	in	in	ADP
ajlm-463	17	6	6/43	6/43	NUM
ajlm-463	17	7	(	(	PUNCT
ajlm-463	17	8	14	14	NUM
ajlm-463	17	9	%	%	NOUN
ajlm-463	17	10	)	)	PUNCT
ajlm-463	17	11	of	of	ADP
ajlm-463	17	12	the	the	DET
ajlm-463	17	13	resistant	resistant	ADJ
ajlm-463	17	14	isolates	isolate	NOUN
ajlm-463	17	15	.	.	PUNCT
ajlm-463	18	1	no	no	DET
ajlm-463	18	2	novel	novel	ADJ
ajlm-463	18	3	rpob	rpob	ADJ
ajlm-463	18	4	mutations	mutation	NOUN
ajlm-463	18	5	other	other	ADJ
ajlm-463	18	6	than	than	ADP
ajlm-463	18	7	those	those	PRON
ajlm-463	18	8	previously	previously	ADV
ajlm-463	18	9	described	describe	VERB
ajlm-463	18	10	were	be	AUX
ajlm-463	18	11	found	find	VERB
ajlm-463	18	12	among	among	ADP
ajlm-463	18	13	the	the	DET
ajlm-463	18	14	rifampicin	rifampicin	NOUN
ajlm-463	18	15	-	-	PUNCT
ajlm-463	18	16	resistant	resistant	ADJ
ajlm-463	18	17	m.	m.	NOUN
ajlm-463	18	18	tuberculosis	tuberculosis	PRON
ajlm-463	18	19	complex	complex	ADJ
ajlm-463	18	20	strains	strain	NOUN
ajlm-463	18	21	.	.	PUNCT
ajlm-463	19	1	conclusion	conclusion	NOUN
ajlm-463	19	2	:	:	PUNCT
ajlm-463	19	3	this	this	DET
ajlm-463	19	4	study	study	NOUN
ajlm-463	19	5	is	be	AUX
ajlm-463	19	6	the	the	DET
ajlm-463	19	7	first	first	ADJ
ajlm-463	19	8	to	to	PART
ajlm-463	19	9	characterise	characterise	VERB
ajlm-463	19	10	rifampicin	rifampicin	VERB
ajlm-463	19	11	resistance	resistance	NOUN
ajlm-463	19	12	in	in	ADP
ajlm-463	19	13	malawi	malawi	PROPN
ajlm-463	19	14	.	.	PUNCT
ajlm-463	20	1	the	the	DET
ajlm-463	20	2	chain	chain	NOUN
ajlm-463	20	3	-	-	PUNCT
ajlm-463	20	4	termination	termination	NOUN
ajlm-463	20	5	dna	dna	NOUN
ajlm-463	20	6	sequencing	sequencing	NOUN
ajlm-463	20	7	employed	employ	VERB
ajlm-463	20	8	in	in	ADP
ajlm-463	20	9	this	this	DET
ajlm-463	20	10	study	study	NOUN
ajlm-463	20	11	is	be	AUX
ajlm-463	20	12	a	a	DET
ajlm-463	20	13	standard	standard	ADJ
ajlm-463	20	14	method	method	NOUN
ajlm-463	20	15	for	for	ADP
ajlm-463	20	16	the	the	DET
ajlm-463	20	17	determination	determination	NOUN
ajlm-463	20	18	of	of	ADP
ajlm-463	20	19	nucleotide	nucleotide	ADJ
ajlm-463	20	20	sequences	sequence	NOUN
ajlm-463	20	21	and	and	CCONJ
ajlm-463	20	22	can	can	AUX
ajlm-463	20	23	be	be	AUX
ajlm-463	20	24	used	use	VERB
ajlm-463	20	25	to	to	PART
ajlm-463	20	26	confirm	confirm	VERB
ajlm-463	20	27	rifampicin	rifampicin	VERB
ajlm-463	20	28	resistance	resistance	NOUN
ajlm-463	20	29	obtained	obtain	VERB
ajlm-463	20	30	using	use	VERB
ajlm-463	20	31	other	other	ADJ
ajlm-463	20	32	assays	assay	NOUN
ajlm-463	20	33	,	,	PUNCT
ajlm-463	20	34	including	include	VERB
ajlm-463	20	35	the	the	DET
ajlm-463	20	36	xpert	xpert	PROPN
ajlm-463	20	37	mtb	mtb	PROPN
ajlm-463	20	38	/	/	SYM
ajlm-463	20	39	rif	rif	PROPN
ajlm-463	20	40	.	.	PUNCT
ajlm-463	20	41	further	further	ADJ
ajlm-463	20	42	molecular	molecular	ADJ
ajlm-463	20	43	cluster	cluster	NOUN
ajlm-463	20	44	analysis	analysis	NOUN
ajlm-463	20	45	,	,	PUNCT
ajlm-463	20	46	such	such	ADJ
ajlm-463	20	47	as	as	ADP
ajlm-463	20	48	spoligotyping	spoligotype	VERB
ajlm-463	20	49	and	and	CCONJ
ajlm-463	20	50	dna	dna	PROPN
ajlm-463	20	51	finger	finger	NOUN
ajlm-463	20	52	printing	printing	NOUN
ajlm-463	20	53	,	,	PUNCT
ajlm-463	20	54	is	be	AUX
ajlm-463	20	55	still	still	ADV
ajlm-463	20	56	required	require	VERB
ajlm-463	20	57	to	to	PART
ajlm-463	20	58	determine	determine	VERB
ajlm-463	20	59	transmission	transmission	NOUN
ajlm-463	20	60	dynamics	dynamic	NOUN
ajlm-463	20	61	and	and	CCONJ
ajlm-463	20	62	the	the	DET
ajlm-463	20	63	epidemiological	epidemiological	ADJ
ajlm-463	20	64	link	link	NOUN
ajlm-463	20	65	of	of	ADP
ajlm-463	20	66	the	the	DET
ajlm-463	20	67	mutated	mutate	VERB
ajlm-463	20	68	strains	strain	NOUN
ajlm-463	20	69	.	.	PUNCT
ajlm-463	21	1	introduction	introduction	NOUN
ajlm-463	21	2	tuberculosis	tuberculosis	NOUN
ajlm-463	21	3	remains	remain	VERB
ajlm-463	21	4	an	an	DET
ajlm-463	21	5	important	important	ADJ
ajlm-463	21	6	public	public	ADJ
ajlm-463	21	7	health	health	NOUN
ajlm-463	21	8	problem	problem	NOUN
ajlm-463	21	9	especially	especially	ADV
ajlm-463	21	10	in	in	ADP
ajlm-463	21	11	the	the	DET
ajlm-463	21	12	developing	develop	VERB
ajlm-463	21	13	world	world	NOUN
ajlm-463	21	14	.	.	PUNCT
ajlm-463	22	1	the	the	DET
ajlm-463	22	2	global	global	ADJ
ajlm-463	22	3	impact	impact	NOUN
ajlm-463	22	4	of	of	ADP
ajlm-463	22	5	tuberculosis	tuberculosis	NOUN
ajlm-463	22	6	is	be	AUX
ajlm-463	22	7	significant	significant	ADJ
ajlm-463	22	8	,	,	PUNCT
ajlm-463	22	9	with	with	ADP
ajlm-463	22	10	an	an	DET
ajlm-463	22	11	annual	annual	ADJ
ajlm-463	22	12	estimate	estimate	NOUN
ajlm-463	22	13	of	of	ADP
ajlm-463	22	14	9.6	9.6	NUM
ajlm-463	22	15	million	million	NUM
ajlm-463	22	16	tuberculosis	tuberculosis	NOUN
ajlm-463	22	17	cases	case	NOUN
ajlm-463	22	18	and	and	CCONJ
ajlm-463	22	19	over	over	ADP
ajlm-463	22	20	1.5	1.5	NUM
ajlm-463	22	21	million	million	NUM
ajlm-463	22	22	deaths	death	NOUN
ajlm-463	22	23	due	due	ADJ
ajlm-463	22	24	to	to	ADP
ajlm-463	22	25	tuberculosis	tuberculosis	NOUN
ajlm-463	22	26	in	in	ADP
ajlm-463	22	27	2014.1	2014.1	NUM
ajlm-463	22	28	the	the	DET
ajlm-463	22	29	tuberculosis	tuberculosis	NOUN
ajlm-463	22	30	burden	burden	NOUN
ajlm-463	22	31	is	be	AUX
ajlm-463	22	32	worsened	worsen	VERB
ajlm-463	22	33	by	by	ADP
ajlm-463	22	34	the	the	DET
ajlm-463	22	35	emergence	emergence	NOUN
ajlm-463	22	36	and	and	CCONJ
ajlm-463	22	37	spread	spread	VERB
ajlm-463	22	38	of	of	ADP
ajlm-463	22	39	multi	multi	ADJ
ajlm-463	22	40	-	-	ADJ
ajlm-463	22	41	drug	drug	ADJ
ajlm-463	22	42	resistant	resistant	ADJ
ajlm-463	22	43	(	(	PUNCT
ajlm-463	22	44	mdr	mdr	NOUN
ajlm-463	22	45	)	)	PUNCT
ajlm-463	22	46	tuberculosis	tuberculosis	NOUN
ajlm-463	22	47	cases	case	NOUN
ajlm-463	22	48	,	,	PUNCT
ajlm-463	22	49	defined	define	VERB
ajlm-463	22	50	as	as	ADP
ajlm-463	22	51	simultaneous	simultaneous	ADJ
ajlm-463	22	52	resistance	resistance	NOUN
ajlm-463	22	53	to	to	ADP
ajlm-463	22	54	at	at	ADV
ajlm-463	22	55	least	least	ADV
ajlm-463	22	56	rifampicin	rifampicin	VERB
ajlm-463	22	57	and	and	CCONJ
ajlm-463	22	58	isoniazid	isoniazid	NOUN
ajlm-463	22	59	,	,	PUNCT
ajlm-463	22	60	with	with	ADP
ajlm-463	22	61	or	or	CCONJ
ajlm-463	22	62	without	without	ADP
ajlm-463	22	63	resistance	resistance	NOUN
ajlm-463	22	64	to	to	ADP
ajlm-463	22	65	any	any	DET
ajlm-463	22	66	other	other	ADJ
ajlm-463	22	67	drug.1	drug.1	NOUN
ajlm-463	22	68	in	in	ADP
ajlm-463	22	69	malawi	malawi	PROPN
ajlm-463	22	70	,	,	PUNCT
ajlm-463	22	71	there	there	PRON
ajlm-463	22	72	were	be	VERB
ajlm-463	22	73	5564	5564	NUM
ajlm-463	22	74	new	new	ADJ
ajlm-463	22	75	smear	smear	VERB
ajlm-463	22	76	-	-	PUNCT
ajlm-463	22	77	positive	positive	ADJ
ajlm-463	22	78	cases	case	NOUN
ajlm-463	22	79	of	of	ADP
ajlm-463	22	80	tuberculosis	tuberculosis	NOUN
ajlm-463	22	81	registered	register	VERB
ajlm-463	22	82	in	in	ADP
ajlm-463	22	83	2014.1	2014.1	NUM
ajlm-463	22	84	patients	patient	NOUN
ajlm-463	22	85	diagnosed	diagnose	VERB
ajlm-463	22	86	with	with	ADP
ajlm-463	22	87	tuberculosis	tuberculosis	NOUN
ajlm-463	22	88	are	be	AUX
ajlm-463	22	89	treated	treat	VERB
ajlm-463	22	90	with	with	ADP
ajlm-463	22	91	the	the	DET
ajlm-463	22	92	standard	standard	ADJ
ajlm-463	22	93	quadruple	quadruple	ADJ
ajlm-463	22	94	antibiotic	antibiotic	ADJ
ajlm-463	22	95	therapy	therapy	NOUN
ajlm-463	22	96	recommended	recommend	VERB
ajlm-463	22	97	for	for	ADP
ajlm-463	22	98	drug	drug	NOUN
ajlm-463	22	99	-	-	PUNCT
ajlm-463	22	100	susceptible	susceptible	ADJ
ajlm-463	22	101	tuberculosis	tuberculosis	NOUN
ajlm-463	22	102	(	(	PUNCT
ajlm-463	22	103	rifampicin	rifampicin	VERB
ajlm-463	22	104	,	,	PUNCT
ajlm-463	22	105	isoniazid	isoniazid	NOUN
ajlm-463	22	106	,	,	PUNCT
ajlm-463	22	107	ethambutol	ethambutol	ADJ
ajlm-463	22	108	and	and	CCONJ
ajlm-463	22	109	pyrazinamide	pyrazinamide	NOUN
ajlm-463	22	110	)	)	PUNCT
ajlm-463	22	111	.	.	PUNCT
ajlm-463	23	1	rapid	rapid	ADJ
ajlm-463	23	2	detection	detection	NOUN
ajlm-463	23	3	of	of	ADP
ajlm-463	23	4	drug	drug	NOUN
ajlm-463	23	5	resistance	resistance	NOUN
ajlm-463	23	6	is	be	AUX
ajlm-463	23	7	crucial	crucial	ADJ
ajlm-463	23	8	in	in	ADP
ajlm-463	23	9	choosing	choose	VERB
ajlm-463	23	10	the	the	DET
ajlm-463	23	11	most	most	ADV
ajlm-463	23	12	effective	effective	ADJ
ajlm-463	23	13	treatment	treatment	NOUN
ajlm-463	23	14	to	to	ADP
ajlm-463	23	15	avert	avert	ADJ
ajlm-463	23	16	morbidity	morbidity	NOUN
ajlm-463	23	17	and	and	CCONJ
ajlm-463	23	18	mortality	mortality	NOUN
ajlm-463	23	19	of	of	ADP
ajlm-463	23	20	infected	infect	VERB
ajlm-463	23	21	individuals	individual	NOUN
ajlm-463	23	22	and	and	CCONJ
ajlm-463	23	23	reduce	reduce	VERB
ajlm-463	23	24	the	the	DET
ajlm-463	23	25	risk	risk	NOUN
ajlm-463	23	26	of	of	ADP
ajlm-463	23	27	mdr	mdr	PROPN
ajlm-463	23	28	tuberculosis	tuberculosis	PROPN
ajlm-463	23	29	transmission.1	transmission.1	PROPN
ajlm-463	23	30	rifampicin	rifampicin	VERB
ajlm-463	23	31	,	,	PUNCT
ajlm-463	23	32	if	if	SCONJ
ajlm-463	23	33	the	the	DET
ajlm-463	23	34	isolate	isolate	NOUN
ajlm-463	23	35	is	be	AUX
ajlm-463	23	36	susceptible	susceptible	ADJ
ajlm-463	23	37	,	,	PUNCT
ajlm-463	23	38	is	be	AUX
ajlm-463	23	39	a	a	DET
ajlm-463	23	40	very	very	ADV
ajlm-463	23	41	important	important	ADJ
ajlm-463	23	42	component	component	NOUN
ajlm-463	23	43	of	of	ADP
ajlm-463	23	44	the	the	DET
ajlm-463	23	45	current	current	ADJ
ajlm-463	23	46	tuberculosis	tuberculosis	NOUN
ajlm-463	23	47	treatment	treatment	NOUN
ajlm-463	23	48	regimen	regiman	NOUN
ajlm-463	23	49	and	and	CCONJ
ajlm-463	23	50	has	have	AUX
ajlm-463	23	51	proved	prove	VERB
ajlm-463	23	52	to	to	PART
ajlm-463	23	53	be	be	AUX
ajlm-463	23	54	effective	effective	ADJ
ajlm-463	23	55	to	to	ADP
ajlm-463	23	56	both	both	CCONJ
ajlm-463	23	57	susceptible	susceptible	ADJ
ajlm-463	23	58	strains	strain	NOUN
ajlm-463	23	59	and	and	CCONJ
ajlm-463	23	60	strains	strain	NOUN
ajlm-463	23	61	resistant	resistant	ADJ
ajlm-463	23	62	to	to	ADP
ajlm-463	23	63	streptomycin	streptomycin	PROPN
ajlm-463	23	64	and	and	CCONJ
ajlm-463	23	65	isoniazid.1	isoniazid.1	PROPN
ajlm-463	24	1	however	however	ADV
ajlm-463	24	2	,	,	PUNCT
ajlm-463	24	3	there	there	PRON
ajlm-463	24	4	is	be	VERB
ajlm-463	24	5	growing	grow	VERB
ajlm-463	24	6	resistance	resistance	NOUN
ajlm-463	24	7	to	to	ADP
ajlm-463	24	8	rifampicin	rifampicin	VERB
ajlm-463	24	9	,	,	PUNCT
ajlm-463	24	10	largely	largely	ADV
ajlm-463	24	11	due	due	ADJ
ajlm-463	24	12	to	to	ADP
ajlm-463	24	13	particular	particular	ADJ
ajlm-463	24	14	genomic	genomic	NOUN
ajlm-463	24	15	mutations	mutation	NOUN
ajlm-463	24	16	in	in	ADP
ajlm-463	24	17	the	the	DET
ajlm-463	24	18	rpob	rpob	ADJ
ajlm-463	24	19	gene	gene	NOUN
ajlm-463	24	20	of	of	ADP
ajlm-463	24	21	mycobacterium	mycobacterium	NOUN
ajlm-463	24	22	tuberculosis.2	tuberculosis.2	VERB
ajlm-463	24	23	the	the	DET
ajlm-463	24	24	rpob	rpob	ADJ
ajlm-463	24	25	gene	gene	NOUN
ajlm-463	24	26	encodes	encode	VERB
ajlm-463	24	27	the	the	DET
ajlm-463	24	28	β	β	X
ajlm-463	24	29	subunit	subunit	NOUN
ajlm-463	24	30	of	of	ADP
ajlm-463	24	31	rna	rna	NOUN
ajlm-463	24	32	polymerase	polymerase	NOUN
ajlm-463	24	33	,	,	PUNCT
ajlm-463	24	34	which	which	PRON
ajlm-463	24	35	is	be	AUX
ajlm-463	24	36	involved	involve	VERB
ajlm-463	24	37	in	in	ADP
ajlm-463	24	38	chain	chain	NOUN
ajlm-463	24	39	initiation	initiation	NOUN
ajlm-463	24	40	and	and	CCONJ
ajlm-463	24	41	elongation	elongation	NOUN
ajlm-463	24	42	.	.	PUNCT
ajlm-463	25	1	a	a	DET
ajlm-463	25	2	signature	signature	NOUN
ajlm-463	25	3	sequence	sequence	NOUN
ajlm-463	25	4	for	for	ADP
ajlm-463	25	5	m.	m.	NOUN
ajlm-463	25	6	tuberculosis	tuberculosis	NOUN
ajlm-463	25	7	identification	identification	NOUN
ajlm-463	25	8	is	be	AUX
ajlm-463	25	9	contained	contain	VERB
ajlm-463	25	10	in	in	ADP
ajlm-463	25	11	this	this	DET
ajlm-463	25	12	region.3,4	region.3,4	ADJ
ajlm-463	25	13	mutations	mutation	NOUN
ajlm-463	25	14	in	in	ADP
ajlm-463	25	15	the	the	DET
ajlm-463	25	16	rifampicin	rifampicin	VERB
ajlm-463	25	17	resistance	resistance	NOUN
ajlm-463	25	18	determining	determine	VERB
ajlm-463	25	19	region	region	NOUN
ajlm-463	25	20	(	(	PUNCT
ajlm-463	25	21	rrdr	rrdr	PROPN
ajlm-463	25	22	)	)	PUNCT
ajlm-463	25	23	of	of	ADP
ajlm-463	25	24	this	this	DET
ajlm-463	25	25	gene	gene	NOUN
ajlm-463	25	26	(	(	PUNCT
ajlm-463	25	27	codons	codon	NOUN
ajlm-463	25	28	507–533	507–533	NUM
ajlm-463	25	29	)	)	PUNCT
ajlm-463	25	30	are	be	AUX
ajlm-463	25	31	associated	associate	VERB
ajlm-463	25	32	with	with	ADP
ajlm-463	25	33	rifampicin	rifampicin	VERB
ajlm-463	25	34	resistance.5	resistance.5	ADJ
ajlm-463	25	35	detection	detection	NOUN
ajlm-463	25	36	of	of	ADP
ajlm-463	25	37	such	such	ADJ
ajlm-463	25	38	mutations	mutation	NOUN
ajlm-463	25	39	indicates	indicate	VERB
ajlm-463	25	40	rifampicin	rifampicin	VERB
ajlm-463	25	41	-	-	PUNCT
ajlm-463	25	42	resistant	resistant	ADJ
ajlm-463	25	43	tuberculosis	tuberculosis	NOUN
ajlm-463	25	44	strains	strain	NOUN
ajlm-463	25	45	and	and	CCONJ
ajlm-463	25	46	can	can	AUX
ajlm-463	25	47	be	be	AUX
ajlm-463	25	48	used	use	VERB
ajlm-463	25	49	as	as	ADP
ajlm-463	25	50	a	a	DET
ajlm-463	25	51	predictor	predictor	NOUN
ajlm-463	25	52	for	for	ADP
ajlm-463	25	53	mdr	mdr	PROPN
ajlm-463	25	54	tuberculosis	tuberculosis	NOUN
ajlm-463	25	55	,	,	PUNCT
ajlm-463	25	56	although	although	SCONJ
ajlm-463	25	57	not	not	PART
ajlm-463	25	58	a	a	DET
ajlm-463	25	59	complete	complete	ADJ
ajlm-463	25	60	surrogate	surrogate	ADJ
ajlm-463	25	61	marker.6	marker.6	NOUN
ajlm-463	25	62	globally	globally	ADV
ajlm-463	25	63	,	,	PUNCT
ajlm-463	25	64	it	it	PRON
ajlm-463	25	65	is	be	AUX
ajlm-463	25	66	estimated	estimate	VERB
ajlm-463	25	67	that	that	SCONJ
ajlm-463	25	68	3.3	3.3	NUM
ajlm-463	25	69	%	%	NOUN
ajlm-463	25	70	of	of	ADP
ajlm-463	25	71	new	new	ADJ
ajlm-463	25	72	cases	case	NOUN
ajlm-463	25	73	and	and	CCONJ
ajlm-463	25	74	20	20	NUM
ajlm-463	25	75	%	%	NOUN
ajlm-463	25	76	of	of	ADP
ajlm-463	25	77	previously	previously	ADV
ajlm-463	25	78	-	-	PUNCT
ajlm-463	25	79	treated	treat	VERB
ajlm-463	25	80	cases	case	NOUN
ajlm-463	25	81	have	have	VERB
ajlm-463	25	82	mdr	mdr	NOUN
ajlm-463	25	83	tuberculosis	tuberculosis	NOUN
ajlm-463	25	84	and	and	CCONJ
ajlm-463	25	85	that	that	SCONJ
ajlm-463	25	86	9.7	9.7	NUM
ajlm-463	25	87	%	%	NOUN
ajlm-463	25	88	of	of	ADP
ajlm-463	25	89	these	these	DET
ajlm-463	25	90	cases	case	NOUN
ajlm-463	25	91	have	have	VERB
ajlm-463	25	92	pre	pre	VERB
ajlm-463	25	93	-	-	ADJ
ajlm-463	25	94	extensively	extensively	ADV
ajlm-463	25	95	drug	drug	NOUN
ajlm-463	25	96	resistant	resistant	ADJ
ajlm-463	25	97	tuberculosis.1	tuberculosis.1	NOUN
ajlm-463	25	98	a	a	DET
ajlm-463	25	99	substantial	substantial	ADJ
ajlm-463	25	100	percentage	percentage	NOUN
ajlm-463	25	101	(	(	PUNCT
ajlm-463	25	102	37	37	NUM
ajlm-463	25	103	%	%	NOUN
ajlm-463	25	104	)	)	PUNCT
ajlm-463	25	105	of	of	ADP
ajlm-463	25	106	new	new	ADJ
ajlm-463	25	107	tuberculosis	tuberculosis	NOUN
ajlm-463	25	108	cases	case	NOUN
ajlm-463	25	109	and	and	CCONJ
ajlm-463	25	110	a	a	DET
ajlm-463	25	111	staggering	staggering	ADJ
ajlm-463	25	112	percentage	percentage	NOUN
ajlm-463	25	113	(	(	PUNCT
ajlm-463	25	114	74	74	NUM
ajlm-463	25	115	%	%	NOUN
ajlm-463	25	116	)	)	PUNCT
ajlm-463	25	117	of	of	ADP
ajlm-463	25	118	the	the	DET
ajlm-463	25	119	global	global	ADJ
ajlm-463	25	120	estimate	estimate	NOUN
ajlm-463	25	121	of	of	ADP
ajlm-463	25	122	mdr	mdr	PROPN
ajlm-463	25	123	tuberculosis	tuberculosis	PROPN
ajlm-463	25	124	incident	incident	NOUN
ajlm-463	25	125	cases	case	NOUN
ajlm-463	25	126	were	be	AUX
ajlm-463	25	127	not	not	PART
ajlm-463	25	128	reported	report	VERB
ajlm-463	25	129	or	or	CCONJ
ajlm-463	25	130	remained	remain	VERB
ajlm-463	25	131	undiagnosed	undiagnosed	ADJ
ajlm-463	25	132	in	in	ADP
ajlm-463	25	133	2014	2014	NUM
ajlm-463	25	134	.	.	PUNCT
ajlm-463	26	1	determination	determination	NOUN
ajlm-463	26	2	of	of	ADP
ajlm-463	26	3	the	the	DET
ajlm-463	26	4	pattern	pattern	NOUN
ajlm-463	26	5	of	of	ADP
ajlm-463	26	6	drug	drug	NOUN
ajlm-463	26	7	resistance	resistance	NOUN
ajlm-463	26	8	is	be	AUX
ajlm-463	26	9	performed	perform	VERB
ajlm-463	26	10	in	in	ADP
ajlm-463	26	11	less	less	ADJ
ajlm-463	26	12	than	than	ADP
ajlm-463	26	13	3	3	NUM
ajlm-463	26	14	%	%	NOUN
ajlm-463	26	15	of	of	ADP
ajlm-463	26	16	people	people	NOUN
ajlm-463	26	17	diagnosed	diagnose	VERB
ajlm-463	26	18	with	with	ADP
ajlm-463	26	19	tuberculosis	tuberculosis	NOUN
ajlm-463	26	20	worldwide.1,7,8	worldwide.1,7,8	NOUN
ajlm-463	26	21	phenotypic	phenotypic	ADJ
ajlm-463	26	22	drug	drug	NOUN
ajlm-463	26	23	susceptibility	susceptibility	NOUN
ajlm-463	26	24	testing	testing	NOUN
ajlm-463	26	25	(	(	PUNCT
ajlm-463	26	26	dst	dst	NOUN
ajlm-463	26	27	)	)	PUNCT
ajlm-463	26	28	relies	rely	VERB
ajlm-463	26	29	on	on	ADP
ajlm-463	26	30	detection	detection	NOUN
ajlm-463	26	31	of	of	ADP
ajlm-463	26	32	growth	growth	NOUN
ajlm-463	26	33	and	and	CCONJ
ajlm-463	26	34	is	be	AUX
ajlm-463	26	35	performed	perform	VERB
ajlm-463	26	36	using	use	VERB
ajlm-463	26	37	an	an	DET
ajlm-463	26	38	antibiotic	antibiotic	ADJ
ajlm-463	26	39	susceptibility	susceptibility	NOUN
ajlm-463	26	40	testing	testing	NOUN
ajlm-463	26	41	set	set	VERB
ajlm-463	26	42	consisting	consist	VERB
ajlm-463	26	43	of	of	ADP
ajlm-463	26	44	a	a	DET
ajlm-463	26	45	growth	growth	NOUN
ajlm-463	26	46	control	control	NOUN
ajlm-463	26	47	and	and	CCONJ
ajlm-463	26	48	one	one	NUM
ajlm-463	26	49	tube	tube	NOUN
ajlm-463	26	50	for	for	ADP
ajlm-463	26	51	each	each	DET
ajlm-463	26	52	anti	anti	ADJ
ajlm-463	26	53	-	-	ADJ
ajlm-463	26	54	tuberculosis	tuberculosis	ADJ
ajlm-463	26	55	test	test	NOUN
ajlm-463	26	56	drug	drug	NOUN
ajlm-463	26	57	,	,	PUNCT
ajlm-463	26	58	with	with	ADP
ajlm-463	26	59	known	known	ADJ
ajlm-463	26	60	concentration.9	concentration.9	NOUN
ajlm-463	26	61	phenotypic	phenotypic	NOUN
ajlm-463	26	62	dst	dst	NOUN
ajlm-463	26	63	is	be	AUX
ajlm-463	26	64	widely	widely	ADV
ajlm-463	26	65	used	use	VERB
ajlm-463	26	66	in	in	ADP
ajlm-463	26	67	limited	limited	ADJ
ajlm-463	26	68	-	-	PUNCT
ajlm-463	26	69	resource	resource	NOUN
ajlm-463	26	70	settings	setting	NOUN
ajlm-463	26	71	.	.	PUNCT
ajlm-463	27	1	this	this	DET
ajlm-463	27	2	method	method	NOUN
ajlm-463	27	3	is	be	AUX
ajlm-463	27	4	inexpensive	inexpensive	ADJ
ajlm-463	27	5	and	and	CCONJ
ajlm-463	27	6	accurate	accurate	ADJ
ajlm-463	27	7	,	,	PUNCT
ajlm-463	27	8	though	though	SCONJ
ajlm-463	27	9	time	time	NOUN
ajlm-463	27	10	consuming	consume	VERB
ajlm-463	27	11	due	due	ADP
ajlm-463	27	12	to	to	ADP
ajlm-463	27	13	its	its	PRON
ajlm-463	27	14	reliance	reliance	NOUN
ajlm-463	27	15	on	on	ADP
ajlm-463	27	16	the	the	DET
ajlm-463	27	17	growth	growth	NOUN
ajlm-463	27	18	of	of	ADP
ajlm-463	27	19	m.	m.	NOUN
ajlm-463	27	20	tuberculosis	tuberculosis	NOUN
ajlm-463	27	21	,	,	PUNCT
ajlm-463	27	22	which	which	PRON
ajlm-463	27	23	takes	take	VERB
ajlm-463	27	24	a	a	DET
ajlm-463	27	25	long	long	ADJ
ajlm-463	27	26	time	time	NOUN
ajlm-463	27	27	to	to	PART
ajlm-463	27	28	obtain	obtain	VERB
ajlm-463	27	29	results.10	results.10	NOUN
ajlm-463	27	30	mutation(s	mutation(s	NOUN
ajlm-463	27	31	)	)	PUNCT
ajlm-463	27	32	in	in	ADP
ajlm-463	27	33	the	the	DET
ajlm-463	27	34	genes	gene	NOUN
ajlm-463	27	35	relevant	relevant	ADJ
ajlm-463	27	36	to	to	ADP
ajlm-463	27	37	responses	response	NOUN
ajlm-463	27	38	to	to	ADP
ajlm-463	27	39	each	each	DET
ajlm-463	27	40	drug	drug	NOUN
ajlm-463	27	41	are	be	AUX
ajlm-463	27	42	associated	associate	VERB
ajlm-463	27	43	with	with	ADP
ajlm-463	27	44	resistance	resistance	NOUN
ajlm-463	27	45	to	to	ADP
ajlm-463	27	46	tuberculosis	tuberculosis	NOUN
ajlm-463	27	47	drugs.10	drugs.10	PROPN
ajlm-463	27	48	genotypic	genotypic	NOUN
ajlm-463	27	49	dst	dst	NOUN
ajlm-463	27	50	methods	method	NOUN
ajlm-463	27	51	target	target	VERB
ajlm-463	27	52	well	well	ADV
ajlm-463	27	53	-	-	PUNCT
ajlm-463	27	54	characterised	characterise	VERB
ajlm-463	27	55	resistance	resistance	NOUN
ajlm-463	27	56	-	-	PUNCT
ajlm-463	27	57	associated	associate	VERB
ajlm-463	27	58	mutations	mutation	NOUN
ajlm-463	27	59	.	.	PUNCT
ajlm-463	28	1	genotypic	genotypic	NOUN
ajlm-463	28	2	dst	dst	PROPN
ajlm-463	28	3	determines	determine	VERB
ajlm-463	28	4	such	such	ADJ
ajlm-463	28	5	mutations	mutation	NOUN
ajlm-463	28	6	in	in	ADP
ajlm-463	28	7	the	the	DET
ajlm-463	28	8	tested	test	VERB
ajlm-463	28	9	gene	gene	NOUN
ajlm-463	28	10	region	region	NOUN
ajlm-463	28	11	only	only	ADV
ajlm-463	28	12	and	and	CCONJ
ajlm-463	28	13	as	as	ADP
ajlm-463	28	14	such	such	ADJ
ajlm-463	28	15	,	,	PUNCT
ajlm-463	28	16	unknown	unknown	ADJ
ajlm-463	28	17	or	or	CCONJ
ajlm-463	28	18	less	less	ADV
ajlm-463	28	19	frequent	frequent	ADJ
ajlm-463	28	20	mutations	mutation	NOUN
ajlm-463	28	21	might	might	AUX
ajlm-463	28	22	be	be	AUX
ajlm-463	28	23	missed.11,12	missed.11,12	ADJ
ajlm-463	28	24	molecular	molecular	ADJ
ajlm-463	28	25	tools	tool	NOUN
ajlm-463	28	26	for	for	ADP
ajlm-463	28	27	rapid	rapid	ADJ
ajlm-463	28	28	dst	dst	NOUN
ajlm-463	28	29	are	be	AUX
ajlm-463	28	30	developed	develop	VERB
ajlm-463	28	31	upon	upon	SCONJ
ajlm-463	28	32	a	a	DET
ajlm-463	28	33	better	well	ADJ
ajlm-463	28	34	understanding	understanding	NOUN
ajlm-463	28	35	of	of	ADP
ajlm-463	28	36	mutations	mutation	NOUN
ajlm-463	28	37	responsible	responsible	ADJ
ajlm-463	28	38	for	for	ADP
ajlm-463	28	39	drug	drug	NOUN
ajlm-463	28	40	resistance	resistance	NOUN
ajlm-463	28	41	in	in	ADP
ajlm-463	28	42	the	the	DET
ajlm-463	28	43	bacterial	bacterial	ADJ
ajlm-463	28	44	genome.13,14	genome.13,14	NOUN
ajlm-463	28	45	several	several	ADJ
ajlm-463	28	46	molecular	molecular	ADJ
ajlm-463	28	47	methods	method	NOUN
ajlm-463	28	48	,	,	PUNCT
ajlm-463	28	49	including	include	VERB
ajlm-463	28	50	the	the	DET
ajlm-463	28	51	xpert	xpert	PROPN
ajlm-463	28	52	®	®	PROPN
ajlm-463	28	53	mtb	mtb	PROPN
ajlm-463	28	54	/	/	SYM
ajlm-463	28	55	rif	rif	PROPN
ajlm-463	28	56	(	(	PUNCT
ajlm-463	28	57	cepheid	cepheid	PROPN
ajlm-463	28	58	,	,	PUNCT
ajlm-463	28	59	sunnyvale	sunnyvale	PROPN
ajlm-463	28	60	,	,	PUNCT
ajlm-463	28	61	california	california	PROPN
ajlm-463	28	62	,	,	PUNCT
ajlm-463	28	63	united	united	PROPN
ajlm-463	28	64	states	states	PROPN
ajlm-463	28	65	)	)	PUNCT
ajlm-463	28	66	,	,	PUNCT
ajlm-463	28	67	have	have	AUX
ajlm-463	28	68	been	be	AUX
ajlm-463	28	69	developed	develop	VERB
ajlm-463	28	70	for	for	ADP
ajlm-463	28	71	the	the	DET
ajlm-463	28	72	detection	detection	NOUN
ajlm-463	28	73	of	of	ADP
ajlm-463	28	74	m.	m.	NOUN
ajlm-463	28	75	tuberculosis	tuberculosis	NOUN
ajlm-463	28	76	complex	complex	ADJ
ajlm-463	28	77	dna	dna	NOUN
ajlm-463	28	78	and	and	CCONJ
ajlm-463	28	79	rrdr	rrdr	ADJ
ajlm-463	28	80	mutations	mutation	NOUN
ajlm-463	28	81	associated	associate	VERB
ajlm-463	28	82	with	with	ADP
ajlm-463	28	83	rifampicin	rifampicin	VERB
ajlm-463	28	84	resistance.15,16,17	resistance.15,16,17	PRON
ajlm-463	28	85	the	the	DET
ajlm-463	28	86	world	world	NOUN
ajlm-463	28	87	health	health	NOUN
ajlm-463	28	88	organization	organization	NOUN
ajlm-463	28	89	strongly	strongly	ADV
ajlm-463	28	90	recommends	recommend	VERB
ajlm-463	28	91	the	the	DET
ajlm-463	28	92	use	use	NOUN
ajlm-463	28	93	of	of	ADP
ajlm-463	28	94	xpert	xpert	PROPN
ajlm-463	28	95	mtb	mtb	PROPN
ajlm-463	28	96	/	/	SYM
ajlm-463	28	97	rif	rif	PROPN
ajlm-463	28	98	as	as	ADP
ajlm-463	28	99	the	the	DET
ajlm-463	28	100	initial	initial	ADJ
ajlm-463	28	101	diagnostic	diagnostic	ADJ
ajlm-463	28	102	test	test	NOUN
ajlm-463	28	103	for	for	ADP
ajlm-463	28	104	use	use	NOUN
ajlm-463	28	105	on	on	ADP
ajlm-463	28	106	pulmonary	pulmonary	ADJ
ajlm-463	28	107	specimens	specimen	NOUN
ajlm-463	28	108	from	from	ADP
ajlm-463	28	109	adults	adult	NOUN
ajlm-463	28	110	and	and	CCONJ
ajlm-463	28	111	children	child	NOUN
ajlm-463	28	112	suspected	suspect	VERB
ajlm-463	28	113	of	of	ADP
ajlm-463	28	114	having	have	VERB
ajlm-463	28	115	hiv	hiv	PROPN
ajlm-463	28	116	-	-	PUNCT
ajlm-463	28	117	associated	associate	VERB
ajlm-463	28	118	tuberculosis	tuberculosis	NOUN
ajlm-463	28	119	or	or	CCONJ
ajlm-463	28	120	mdr	mdr	PROPN
ajlm-463	28	121	tuberculosis.1	tuberculosis.1	VERB
ajlm-463	28	122	the	the	DET
ajlm-463	28	123	use	use	NOUN
ajlm-463	28	124	of	of	ADP
ajlm-463	28	125	dna	dna	NOUN
ajlm-463	28	126	sequencing	sequencing	NOUN
ajlm-463	28	127	complements	complement	NOUN
ajlm-463	28	128	the	the	DET
ajlm-463	28	129	above	above	ADJ
ajlm-463	28	130	assay	assay	VERB
ajlm-463	28	131	in	in	ADP
ajlm-463	28	132	detecting	detect	VERB
ajlm-463	28	133	new	new	ADJ
ajlm-463	28	134	mutations	mutation	NOUN
ajlm-463	28	135	,	,	PUNCT
ajlm-463	28	136	as	as	ADV
ajlm-463	28	137	well	well	ADV
ajlm-463	28	138	as	as	ADP
ajlm-463	28	139	confirming	confirm	VERB
ajlm-463	28	140	the	the	DET
ajlm-463	28	141	presence	presence	NOUN
ajlm-463	28	142	of	of	ADP
ajlm-463	28	143	the	the	DET
ajlm-463	28	144	most	most	ADV
ajlm-463	28	145	frequent	frequent	ADJ
ajlm-463	28	146	mutations	mutation	NOUN
ajlm-463	28	147	that	that	PRON
ajlm-463	28	148	could	could	AUX
ajlm-463	28	149	be	be	AUX
ajlm-463	28	150	associated	associate	VERB
ajlm-463	28	151	with	with	ADP
ajlm-463	28	152	drug	drug	NOUN
ajlm-463	28	153	resistance	resistance	NOUN
ajlm-463	28	154	,	,	PUNCT
ajlm-463	28	155	and	and	CCONJ
ajlm-463	28	156	has	have	AUX
ajlm-463	28	157	conferred	confer	VERB
ajlm-463	28	158	excellent	excellent	ADJ
ajlm-463	28	159	benefits	benefit	NOUN
ajlm-463	28	160	to	to	PART
ajlm-463	28	161	patient	patient	VERB
ajlm-463	28	162	care	care	NOUN
ajlm-463	28	163	due	due	ADP
ajlm-463	28	164	to	to	ADP
ajlm-463	28	165	the	the	DET
ajlm-463	28	166	larger	large	ADJ
ajlm-463	28	167	dna	dna	NOUN
ajlm-463	28	168	fragment	fragment	NOUN
ajlm-463	28	169	that	that	PRON
ajlm-463	28	170	is	be	AUX
ajlm-463	28	171	sequenced.18,19	sequenced.18,19	ADJ
ajlm-463	28	172	dna	dna	NOUN
ajlm-463	28	173	sequencing	sequence	VERB
ajlm-463	28	174	determines	determine	VERB
ajlm-463	28	175	mutations	mutation	NOUN
ajlm-463	28	176	by	by	ADP
ajlm-463	28	177	comparing	compare	VERB
ajlm-463	28	178	the	the	DET
ajlm-463	28	179	differences	difference	NOUN
ajlm-463	28	180	between	between	ADP
ajlm-463	28	181	the	the	DET
ajlm-463	28	182	gold	gold	ADJ
ajlm-463	28	183	standard	standard	NOUN
ajlm-463	28	184	(	(	PUNCT
ajlm-463	28	185	h37rv	h37rv	ADP
ajlm-463	28	186	reference	reference	NOUN
ajlm-463	28	187	strain	strain	NOUN
ajlm-463	28	188	)	)	PUNCT
ajlm-463	28	189	and	and	CCONJ
ajlm-463	28	190	the	the	DET
ajlm-463	28	191	test	test	NOUN
ajlm-463	28	192	nucleotide	nucleotide	NOUN
ajlm-463	28	193	sequence.20,21	sequence.20,21	NOUN
ajlm-463	28	194	we	we	PRON
ajlm-463	28	195	aimed	aim	VERB
ajlm-463	28	196	to	to	PART
ajlm-463	28	197	assess	assess	VERB
ajlm-463	28	198	the	the	DET
ajlm-463	28	199	rrdr	rrdr	NOUN
ajlm-463	28	200	of	of	ADP
ajlm-463	28	201	the	the	DET
ajlm-463	28	202	rpob	rpob	ADJ
ajlm-463	28	203	gene	gene	NOUN
ajlm-463	28	204	for	for	ADP
ajlm-463	28	205	mutations	mutation	NOUN
ajlm-463	28	206	in	in	ADP
ajlm-463	28	207	m.	m.	NOUN
ajlm-463	28	208	tuberculosis	tuberculosis	NOUN
ajlm-463	28	209	strains	strain	NOUN
ajlm-463	28	210	that	that	PRON
ajlm-463	28	211	were	be	AUX
ajlm-463	28	212	defined	define	VERB
ajlm-463	28	213	as	as	ADP
ajlm-463	28	214	rifampicin	rifampicin	VERB
ajlm-463	28	215	resistant	resistant	ADJ
ajlm-463	28	216	by	by	ADP
ajlm-463	28	217	the	the	DET
ajlm-463	28	218	xpert	xpert	PROPN
ajlm-463	28	219	mtb	mtb	PROPN
ajlm-463	28	220	/	/	SYM
ajlm-463	28	221	rif	rif	PROPN
ajlm-463	28	222	assay	assay	NOUN
ajlm-463	28	223	and	and	CCONJ
ajlm-463	28	224	to	to	PART
ajlm-463	28	225	establish	establish	VERB
ajlm-463	28	226	the	the	DET
ajlm-463	28	227	prevalence	prevalence	NOUN
ajlm-463	28	228	of	of	ADP
ajlm-463	28	229	such	such	ADJ
ajlm-463	28	230	mutations	mutation	NOUN
ajlm-463	28	231	in	in	ADP
ajlm-463	28	232	tuberculosis	tuberculosis	NOUN
ajlm-463	28	233	-	-	PUNCT
ajlm-463	28	234	infected	infect	VERB
ajlm-463	28	235	malawians	malawian	NOUN
ajlm-463	28	236	.	.	PUNCT
ajlm-463	29	1	methods	method	NOUN
ajlm-463	29	2	ethical	ethical	ADJ
ajlm-463	29	3	considerations	consideration	NOUN
ajlm-463	29	4	approvals	approval	NOUN
ajlm-463	29	5	for	for	ADP
ajlm-463	29	6	this	this	DET
ajlm-463	29	7	study	study	NOUN
ajlm-463	29	8	were	be	AUX
ajlm-463	29	9	granted	grant	VERB
ajlm-463	29	10	by	by	ADP
ajlm-463	29	11	university	university	NOUN
ajlm-463	29	12	of	of	ADP
ajlm-463	29	13	the	the	DET
ajlm-463	29	14	witwatersrand	witwatersrand	NOUN
ajlm-463	29	15	human	human	PROPN
ajlm-463	29	16	research	research	PROPN
ajlm-463	29	17	ethics	ethic	NOUN
ajlm-463	29	18	committee	committee	PROPN
ajlm-463	29	19	(	(	PUNCT
ajlm-463	29	20	m120256	m120256	PROPN
ajlm-463	29	21	)	)	PUNCT
ajlm-463	29	22	,	,	PUNCT
ajlm-463	29	23	national	national	PROPN
ajlm-463	29	24	health	health	PROPN
ajlm-463	29	25	sciences	sciences	PROPN
ajlm-463	29	26	research	research	PROPN
ajlm-463	29	27	committee	committee	PROPN
ajlm-463	29	28	(	(	PUNCT
ajlm-463	29	29	nhsrc	nhsrc	PROPN
ajlm-463	29	30	)	)	PUNCT
ajlm-463	29	31	in	in	ADP
ajlm-463	29	32	malawi	malawi	PROPN
ajlm-463	29	33	(	(	PUNCT
ajlm-463	29	34	nhsrc	nhsrc	PROPN
ajlm-463	29	35	#	#	NOUN
ajlm-463	29	36	999	999	NUM
ajlm-463	29	37	)	)	PUNCT
ajlm-463	29	38	and	and	CCONJ
ajlm-463	29	39	the	the	DET
ajlm-463	29	40	university	university	PROPN
ajlm-463	29	41	of	of	ADP
ajlm-463	29	42	north	north	PROPN
ajlm-463	29	43	carolina	carolina	PROPN
ajlm-463	29	44	(	(	PUNCT
ajlm-463	29	45	unc	unc	PROPN
ajlm-463	29	46	;	;	PUNCT
ajlm-463	29	47	chapel	chapel	NOUN
ajlm-463	29	48	hill	hill	PROPN
ajlm-463	29	49	)	)	PUNCT
ajlm-463	29	50	institutional	institutional	ADJ
ajlm-463	29	51	review	review	NOUN
ajlm-463	29	52	board	board	NOUN
ajlm-463	29	53	(	(	PUNCT
ajlm-463	29	54	cid	cid	NOUN
ajlm-463	29	55	1211	1211	NUM
ajlm-463	29	56	)	)	PUNCT
ajlm-463	29	57	.	.	PUNCT
ajlm-463	30	1	obtaining	obtain	VERB
ajlm-463	30	2	consent	consent	NOUN
ajlm-463	30	3	was	be	AUX
ajlm-463	30	4	waived	waive	VERB
ajlm-463	30	5	because	because	SCONJ
ajlm-463	30	6	the	the	DET
ajlm-463	30	7	study	study	NOUN
ajlm-463	30	8	used	use	VERB
ajlm-463	30	9	previously	previously	ADV
ajlm-463	30	10	-	-	PUNCT
ajlm-463	30	11	stored	store	VERB
ajlm-463	30	12	and	and	CCONJ
ajlm-463	30	13	residual	residual	ADJ
ajlm-463	30	14	sputum	sputum	NOUN
ajlm-463	30	15	pellets	pellet	NOUN
ajlm-463	30	16	,	,	PUNCT
ajlm-463	30	17	and	and	CCONJ
ajlm-463	30	18	consent	consent	NOUN
ajlm-463	30	19	from	from	ADP
ajlm-463	30	20	patients	patient	NOUN
ajlm-463	30	21	was	be	AUX
ajlm-463	30	22	given	give	VERB
ajlm-463	30	23	during	during	ADP
ajlm-463	30	24	recruitment	recruitment	NOUN
ajlm-463	30	25	and/or	and/or	CCONJ
ajlm-463	30	26	this	this	PRON
ajlm-463	30	27	was	be	AUX
ajlm-463	30	28	part	part	NOUN
ajlm-463	30	29	of	of	ADP
ajlm-463	30	30	routine	routine	ADJ
ajlm-463	30	31	testing	testing	NOUN
ajlm-463	30	32	for	for	ADP
ajlm-463	30	33	tuberculosis	tuberculosis	NOUN
ajlm-463	30	34	drug	drug	NOUN
ajlm-463	30	35	resistance	resistance	NOUN
ajlm-463	30	36	.	.	PUNCT
ajlm-463	31	1	study	study	NOUN
ajlm-463	31	2	population	population	NOUN
ajlm-463	31	3	we	we	PRON
ajlm-463	31	4	conducted	conduct	VERB
ajlm-463	31	5	this	this	DET
ajlm-463	31	6	study	study	NOUN
ajlm-463	31	7	using	use	VERB
ajlm-463	31	8	processed	process	VERB
ajlm-463	31	9	sputum	sputum	NOUN
ajlm-463	31	10	sediments	sediment	NOUN
ajlm-463	31	11	(	(	PUNCT
ajlm-463	31	12	pellets	pellet	NOUN
ajlm-463	31	13	)	)	PUNCT
ajlm-463	31	14	from	from	ADP
ajlm-463	31	15	new	new	ADJ
ajlm-463	31	16	and	and	CCONJ
ajlm-463	31	17	previously	previously	ADV
ajlm-463	31	18	-	-	PUNCT
ajlm-463	31	19	treated	treat	VERB
ajlm-463	31	20	patients	patient	NOUN
ajlm-463	31	21	,	,	PUNCT
ajlm-463	31	22	≥	≥	NOUN
ajlm-463	31	23	18	18	NUM
ajlm-463	31	24	years	year	NOUN
ajlm-463	31	25	of	of	ADP
ajlm-463	31	26	age	age	NOUN
ajlm-463	31	27	.	.	PUNCT
ajlm-463	32	1	demographic	demographic	ADJ
ajlm-463	32	2	and	and	CCONJ
ajlm-463	32	3	clinical	clinical	ADJ
ajlm-463	32	4	information	information	NOUN
ajlm-463	32	5	was	be	AUX
ajlm-463	32	6	collected	collect	VERB
ajlm-463	32	7	from	from	ADP
ajlm-463	32	8	the	the	DET
ajlm-463	32	9	respective	respective	ADJ
ajlm-463	32	10	laboratory	laboratory	NOUN
ajlm-463	32	11	tuberculosis	tuberculosis	NOUN
ajlm-463	32	12	registers	register	NOUN
ajlm-463	32	13	and	and	CCONJ
ajlm-463	32	14	entered	enter	VERB
ajlm-463	32	15	in	in	ADP
ajlm-463	32	16	excel	excel	PROPN
ajlm-463	32	17	(	(	PUNCT
ajlm-463	32	18	microsoft	microsoft	PROPN
ajlm-463	32	19	,	,	PUNCT
ajlm-463	32	20	inc	inc	PROPN
ajlm-463	32	21	.	.	PROPN
ajlm-463	32	22	,	,	PUNCT
ajlm-463	32	23	redmond	redmond	PROPN
ajlm-463	32	24	,	,	PUNCT
ajlm-463	32	25	washington	washington	PROPN
ajlm-463	32	26	,	,	PUNCT
ajlm-463	32	27	united	united	PROPN
ajlm-463	32	28	states	states	PROPN
ajlm-463	32	29	)	)	PUNCT
ajlm-463	32	30	spreadsheets	spreadsheet	NOUN
ajlm-463	32	31	.	.	PUNCT
ajlm-463	33	1	both	both	PRON
ajlm-463	33	2	retrospective	retrospective	ADJ
ajlm-463	33	3	and	and	CCONJ
ajlm-463	33	4	prospective	prospective	ADJ
ajlm-463	33	5	pellets	pellet	NOUN
ajlm-463	33	6	(	(	PUNCT
ajlm-463	33	7	n	n	NOUN
ajlm-463	33	8	=	=	SYM
ajlm-463	33	9	995	995	NUM
ajlm-463	33	10	)	)	PUNCT
ajlm-463	33	11	were	be	AUX
ajlm-463	33	12	used	use	VERB
ajlm-463	33	13	in	in	ADP
ajlm-463	33	14	the	the	DET
ajlm-463	33	15	current	current	ADJ
ajlm-463	33	16	study	study	NOUN
ajlm-463	33	17	.	.	PUNCT
ajlm-463	34	1	retrospective	retrospective	ADJ
ajlm-463	34	2	pellets	pellet	NOUN
ajlm-463	34	3	retrospective	retrospective	ADJ
ajlm-463	34	4	sputum	sputum	NOUN
ajlm-463	34	5	pellets	pellet	NOUN
ajlm-463	34	6	(	(	PUNCT
ajlm-463	34	7	n	n	NOUN
ajlm-463	34	8	=	=	SYM
ajlm-463	34	9	351	351	NUM
ajlm-463	34	10	)	)	PUNCT
ajlm-463	34	11	were	be	AUX
ajlm-463	34	12	collected	collect	VERB
ajlm-463	34	13	between	between	ADP
ajlm-463	34	14	april	april	PROPN
ajlm-463	34	15	2011	2011	NUM
ajlm-463	34	16	and	and	CCONJ
ajlm-463	34	17	july	july	PROPN
ajlm-463	34	18	2012	2012	NUM
ajlm-463	34	19	from	from	ADP
ajlm-463	34	20	a	a	DET
ajlm-463	34	21	study	study	NOUN
ajlm-463	34	22	conducted	conduct	VERB
ajlm-463	34	23	in	in	ADP
ajlm-463	34	24	outpatients	outpatient	NOUN
ajlm-463	34	25	initiating	initiate	VERB
ajlm-463	34	26	tuberculosis	tuberculosis	NOUN
ajlm-463	34	27	treatment	treatment	NOUN
ajlm-463	34	28	at	at	ADP
ajlm-463	34	29	martin	martin	PROPN
ajlm-463	34	30	preuss	preuss	PROPN
ajlm-463	34	31	centre	centre	PROPN
ajlm-463	34	32	at	at	ADP
ajlm-463	34	33	bwaila	bwaila	PROPN
ajlm-463	34	34	hospital	hospital	NOUN
ajlm-463	34	35	(	(	PUNCT
ajlm-463	34	36	bwaila	bwaila	NOUN
ajlm-463	34	37	)	)	PUNCT
ajlm-463	34	38	in	in	ADP
ajlm-463	34	39	lilongwe	lilongwe	PROPN
ajlm-463	34	40	,	,	PUNCT
ajlm-463	34	41	which	which	PRON
ajlm-463	34	42	was	be	AUX
ajlm-463	34	43	looking	look	VERB
ajlm-463	34	44	at	at	ADP
ajlm-463	34	45	the	the	DET
ajlm-463	34	46	prevalence	prevalence	NOUN
ajlm-463	34	47	of	of	ADP
ajlm-463	34	48	drug	drug	NOUN
ajlm-463	34	49	-	-	PUNCT
ajlm-463	34	50	resistant	resistant	ADJ
ajlm-463	34	51	tuberculosis	tuberculosis	NOUN
ajlm-463	34	52	at	at	ADP
ajlm-463	34	53	this	this	DET
ajlm-463	34	54	hiv	hiv	NOUN
ajlm-463	34	55	/	/	SYM
ajlm-463	34	56	tuberculosis	tuberculosis	NOUN
ajlm-463	34	57	clinic.22	clinic.22	NOUN
ajlm-463	34	58	sputum	sputum	NOUN
ajlm-463	34	59	samples	sample	NOUN
ajlm-463	34	60	were	be	AUX
ajlm-463	34	61	processed	process	VERB
ajlm-463	34	62	for	for	ADP
ajlm-463	34	63	routine	routine	ADJ
ajlm-463	34	64	culture	culture	NOUN
ajlm-463	34	65	at	at	ADP
ajlm-463	34	66	the	the	DET
ajlm-463	34	67	unc	unc	PROPN
ajlm-463	34	68	project	project	PROPN
ajlm-463	34	69	laboratory	laboratory	NOUN
ajlm-463	34	70	following	follow	VERB
ajlm-463	34	71	the	the	DET
ajlm-463	34	72	n	n	CCONJ
ajlm-463	34	73	-	-	PUNCT
ajlm-463	34	74	acetyl	acetyl	NOUN
ajlm-463	34	75	-	-	PUNCT
ajlm-463	34	76	l	l	NOUN
ajlm-463	34	77	-	-	NOUN
ajlm-463	34	78	cysteine	cysteine	NOUN
ajlm-463	34	79	and	and	CCONJ
ajlm-463	34	80	sodium	sodium	NOUN
ajlm-463	34	81	hydroxide	hydroxide	NOUN
ajlm-463	34	82	(	(	PUNCT
ajlm-463	34	83	nalc	nalc	NOUN
ajlm-463	34	84	-	-	PUNCT
ajlm-463	34	85	naoh	naoh	NOUN
ajlm-463	34	86	)	)	PUNCT
ajlm-463	34	87	method	method	NOUN
ajlm-463	34	88	.	.	PUNCT
ajlm-463	35	1	pellets	pellet	NOUN
ajlm-463	35	2	were	be	AUX
ajlm-463	35	3	inoculated	inoculate	VERB
ajlm-463	35	4	on	on	ADP
ajlm-463	35	5	both	both	DET
ajlm-463	35	6	mycobacterium	mycobacterium	NOUN
ajlm-463	35	7	growth	growth	NOUN
ajlm-463	35	8	indicator	indicator	NOUN
ajlm-463	35	9	tubes	tube	NOUN
ajlm-463	35	10	(	(	PUNCT
ajlm-463	35	11	mgit	mgit	PROPN
ajlm-463	35	12	)	)	PUNCT
ajlm-463	35	13	and	and	CCONJ
ajlm-463	35	14	löwenstein	löwenstein	PROPN
ajlm-463	35	15	jensen	jensen	PROPN
ajlm-463	35	16	media	medium	NOUN
ajlm-463	35	17	.	.	PUNCT
ajlm-463	36	1	dst	dst	PROPN
ajlm-463	36	2	was	be	AUX
ajlm-463	36	3	performed	perform	VERB
ajlm-463	36	4	using	use	VERB
ajlm-463	36	5	the	the	DET
ajlm-463	36	6	hain	hain	NOUN
ajlm-463	36	7	mtbdrplus	mtbdrplus	PROPN
ajlm-463	36	8	assay	assay	PROPN
ajlm-463	36	9	(	(	PUNCT
ajlm-463	36	10	hain	hain	PROPN
ajlm-463	36	11	lifescience	lifescience	PROPN
ajlm-463	36	12	gmbh	gmbh	PROPN
ajlm-463	36	13	,	,	PUNCT
ajlm-463	36	14	nehren	nehren	PROPN
ajlm-463	36	15	,	,	PUNCT
ajlm-463	36	16	germany	germany	PROPN
ajlm-463	36	17	)	)	PUNCT
ajlm-463	36	18	.	.	PUNCT
ajlm-463	37	1	residual	residual	ADJ
ajlm-463	37	2	pellets	pellet	NOUN
ajlm-463	37	3	were	be	AUX
ajlm-463	37	4	stored	store	VERB
ajlm-463	37	5	at	at	ADP
ajlm-463	37	6	-80	-80	NOUN
ajlm-463	37	7	°	°	NOUN
ajlm-463	37	8	c	c	NOUN
ajlm-463	37	9	and	and	CCONJ
ajlm-463	37	10	selected	select	VERB
ajlm-463	37	11	at	at	ADP
ajlm-463	37	12	random	random	ADJ
ajlm-463	37	13	for	for	ADP
ajlm-463	37	14	use	use	NOUN
ajlm-463	37	15	in	in	ADP
ajlm-463	37	16	this	this	DET
ajlm-463	37	17	study	study	NOUN
ajlm-463	37	18	without	without	ADP
ajlm-463	37	19	any	any	DET
ajlm-463	37	20	special	special	ADJ
ajlm-463	37	21	criteria	criterion	NOUN
ajlm-463	37	22	to	to	PART
ajlm-463	37	23	eliminate	eliminate	VERB
ajlm-463	37	24	bias	bias	NOUN
ajlm-463	37	25	.	.	PUNCT
ajlm-463	38	1	prospective	prospective	ADJ
ajlm-463	38	2	pellets	pellet	NOUN
ajlm-463	38	3	prospective	prospective	ADJ
ajlm-463	38	4	sputum	sputum	NOUN
ajlm-463	38	5	pellets	pellet	NOUN
ajlm-463	38	6	came	come	VERB
ajlm-463	38	7	from	from	ADP
ajlm-463	38	8	patients	patient	NOUN
ajlm-463	38	9	suspected	suspect	VERB
ajlm-463	38	10	of	of	ADP
ajlm-463	38	11	drug	drug	NOUN
ajlm-463	38	12	-	-	PUNCT
ajlm-463	38	13	resistant	resistant	ADJ
ajlm-463	38	14	tuberculosis	tuberculosis	NOUN
ajlm-463	38	15	(	(	PUNCT
ajlm-463	38	16	n	n	NOUN
ajlm-463	38	17	=	=	SYM
ajlm-463	38	18	644	644	NUM
ajlm-463	38	19	)	)	PUNCT
ajlm-463	38	20	who	who	PRON
ajlm-463	38	21	presented	present	VERB
ajlm-463	38	22	consecutively	consecutively	ADV
ajlm-463	38	23	to	to	ADP
ajlm-463	38	24	district	district	NOUN
ajlm-463	38	25	hospitals	hospital	NOUN
ajlm-463	38	26	in	in	ADP
ajlm-463	38	27	malawi	malawi	PROPN
ajlm-463	38	28	,	,	PUNCT
ajlm-463	38	29	and	and	CCONJ
ajlm-463	38	30	sputum	sputum	NOUN
ajlm-463	38	31	samples	sample	NOUN
ajlm-463	38	32	were	be	AUX
ajlm-463	38	33	sent	send	VERB
ajlm-463	38	34	to	to	ADP
ajlm-463	38	35	the	the	DET
ajlm-463	38	36	national	national	ADJ
ajlm-463	38	37	tuberculosis	tuberculosis	NOUN
ajlm-463	38	38	reference	reference	NOUN
ajlm-463	38	39	laboratory	laboratory	NOUN
ajlm-463	38	40	(	(	PUNCT
ajlm-463	38	41	ntrl	ntrl	PROPN
ajlm-463	38	42	)	)	PUNCT
ajlm-463	38	43	in	in	ADP
ajlm-463	38	44	lilongwe	lilongwe	PROPN
ajlm-463	38	45	for	for	ADP
ajlm-463	38	46	conventional	conventional	ADJ
ajlm-463	38	47	dst	dst	PROPN
ajlm-463	38	48	between	between	ADP
ajlm-463	38	49	june	june	PROPN
ajlm-463	38	50	2012	2012	NUM
ajlm-463	38	51	and	and	CCONJ
ajlm-463	38	52	may	may	PROPN
ajlm-463	38	53	2014	2014	NUM
ajlm-463	38	54	.	.	PUNCT
ajlm-463	39	1	sputum	sputum	PROPN
ajlm-463	39	2	was	be	AUX
ajlm-463	39	3	processed	process	VERB
ajlm-463	39	4	using	use	VERB
ajlm-463	39	5	the	the	DET
ajlm-463	39	6	nalc	nalc	NOUN
ajlm-463	39	7	-	-	PUNCT
ajlm-463	39	8	naoh	naoh	NOUN
ajlm-463	39	9	method	method	NOUN
ajlm-463	39	10	and	and	CCONJ
ajlm-463	39	11	the	the	DET
ajlm-463	39	12	pellet	pellet	NOUN
ajlm-463	39	13	was	be	AUX
ajlm-463	39	14	split	split	VERB
ajlm-463	39	15	in	in	ADP
ajlm-463	39	16	two	two	NUM
ajlm-463	39	17	.	.	PUNCT
ajlm-463	40	1	the	the	DET
ajlm-463	40	2	first	first	ADJ
ajlm-463	40	3	sample	sample	NOUN
ajlm-463	40	4	was	be	AUX
ajlm-463	40	5	used	use	VERB
ajlm-463	40	6	for	for	ADP
ajlm-463	40	7	routine	routine	ADJ
ajlm-463	40	8	culture	culture	NOUN
ajlm-463	40	9	and	and	CCONJ
ajlm-463	40	10	conventional	conventional	ADJ
ajlm-463	40	11	dst	dst	NOUN
ajlm-463	40	12	at	at	ADP
ajlm-463	40	13	the	the	DET
ajlm-463	40	14	ntrl	ntrl	NOUN
ajlm-463	40	15	,	,	PUNCT
ajlm-463	40	16	while	while	SCONJ
ajlm-463	40	17	the	the	DET
ajlm-463	40	18	other	other	ADJ
ajlm-463	40	19	was	be	AUX
ajlm-463	40	20	stored	store	VERB
ajlm-463	40	21	for	for	ADP
ajlm-463	40	22	up	up	ADP
ajlm-463	40	23	to	to	PART
ajlm-463	40	24	two	two	NUM
ajlm-463	40	25	weeks	week	NOUN
ajlm-463	40	26	at	at	ADP
ajlm-463	40	27	2	2	NUM
ajlm-463	40	28	°	°	ADP
ajlm-463	40	29	c	c	NOUN
ajlm-463	40	30	–	–	PUNCT
ajlm-463	40	31	8	8	NUM
ajlm-463	40	32	°	°	ADP
ajlm-463	40	33	c	c	NOUN
ajlm-463	40	34	for	for	ADP
ajlm-463	40	35	xpert	xpert	PROPN
ajlm-463	40	36	mtb	mtb	PROPN
ajlm-463	40	37	/	/	SYM
ajlm-463	40	38	rif	rif	PROPN
ajlm-463	40	39	testing	testing	NOUN
ajlm-463	40	40	and	and	CCONJ
ajlm-463	40	41	mgit	mgit	ADJ
ajlm-463	40	42	culture	culture	NOUN
ajlm-463	40	43	at	at	ADP
ajlm-463	40	44	the	the	DET
ajlm-463	40	45	unc	unc	PROPN
ajlm-463	40	46	laboratory	laboratory	NOUN
ajlm-463	40	47	.	.	PUNCT
ajlm-463	41	1	mycobacterium	mycobacterium	NOUN
ajlm-463	41	2	cultures	culture	NOUN
ajlm-463	41	3	at	at	ADP
ajlm-463	41	4	the	the	DET
ajlm-463	41	5	unc	unc	PROPN
ajlm-463	41	6	laboratory	laboratory	NOUN
ajlm-463	41	7	pellets	pellet	NOUN
ajlm-463	41	8	were	be	AUX
ajlm-463	41	9	re	re	VERB
ajlm-463	41	10	-	-	VERB
ajlm-463	41	11	suspended	suspend	VERB
ajlm-463	41	12	in	in	ADP
ajlm-463	41	13	1.5	1.5	NUM
ajlm-463	41	14	ml	ml	NOUN
ajlm-463	41	15	of	of	ADP
ajlm-463	41	16	phosphate	phosphate	ADJ
ajlm-463	41	17	buffer	buffer	NOUN
ajlm-463	41	18	and	and	CCONJ
ajlm-463	41	19	split	split	VERB
ajlm-463	41	20	into	into	ADP
ajlm-463	41	21	different	different	ADJ
ajlm-463	41	22	volumes	volume	NOUN
ajlm-463	41	23	.	.	PUNCT
ajlm-463	42	1	one	one	NUM
ajlm-463	42	2	part	part	NOUN
ajlm-463	42	3	was	be	AUX
ajlm-463	42	4	processed	process	VERB
ajlm-463	42	5	for	for	ADP
ajlm-463	42	6	routine	routine	ADJ
ajlm-463	42	7	culture	culture	NOUN
ajlm-463	42	8	using	use	VERB
ajlm-463	42	9	mgit	mgit	NOUN
ajlm-463	42	10	and	and	CCONJ
ajlm-463	42	11	the	the	DET
ajlm-463	42	12	other	other	ADJ
ajlm-463	42	13	was	be	AUX
ajlm-463	42	14	processed	process	VERB
ajlm-463	42	15	on	on	ADP
ajlm-463	42	16	xpert	xpert	PROPN
ajlm-463	42	17	mtb	mtb	PROPN
ajlm-463	42	18	/	/	SYM
ajlm-463	42	19	rif	rif	PROPN
ajlm-463	42	20	(	(	PUNCT
ajlm-463	42	21	0.5	0.5	NUM
ajlm-463	42	22	ml	ml	NOUN
ajlm-463	42	23	)	)	PUNCT
ajlm-463	42	24	.	.	PUNCT
ajlm-463	43	1	mgit	mgit	PROPN
ajlm-463	43	2	tubes	tube	NOUN
ajlm-463	43	3	were	be	AUX
ajlm-463	43	4	inoculated	inoculate	VERB
ajlm-463	43	5	with	with	ADP
ajlm-463	43	6	500	500	NUM
ajlm-463	43	7	µl	µl	NOUN
ajlm-463	43	8	of	of	ADP
ajlm-463	43	9	the	the	DET
ajlm-463	43	10	re	re	ADJ
ajlm-463	43	11	-	-	VERB
ajlm-463	43	12	suspended	suspend	VERB
ajlm-463	43	13	sample	sample	NOUN
ajlm-463	43	14	as	as	ADP
ajlm-463	43	15	previously	previously	ADV
ajlm-463	43	16	described23	described23	NOUN
ajlm-463	43	17	and	and	CCONJ
ajlm-463	43	18	were	be	AUX
ajlm-463	43	19	monitored	monitor	VERB
ajlm-463	43	20	daily	daily	ADV
ajlm-463	43	21	for	for	ADP
ajlm-463	43	22	growth	growth	NOUN
ajlm-463	43	23	using	use	VERB
ajlm-463	43	24	a	a	DET
ajlm-463	43	25	hand	hand	NOUN
ajlm-463	43	26	-	-	PUNCT
ajlm-463	43	27	held	hold	VERB
ajlm-463	43	28	bactec	bactec	ADJ
ajlm-463	43	29	micromgit	micromgit	NOUN
ajlm-463	43	30	reader	reader	NOUN
ajlm-463	43	31	for	for	ADP
ajlm-463	43	32	up	up	ADP
ajlm-463	43	33	to	to	PART
ajlm-463	43	34	42	42	NUM
ajlm-463	43	35	days	day	NOUN
ajlm-463	43	36	.	.	PUNCT
ajlm-463	44	1	smears	smear	NOUN
ajlm-463	44	2	were	be	AUX
ajlm-463	44	3	prepared	prepare	VERB
ajlm-463	44	4	from	from	ADP
ajlm-463	44	5	positive	positive	ADJ
ajlm-463	44	6	cultures	culture	NOUN
ajlm-463	44	7	,	,	PUNCT
ajlm-463	44	8	stained	stain	VERB
ajlm-463	44	9	using	use	VERB
ajlm-463	44	10	ziehl	ziehl	NOUN
ajlm-463	44	11	-	-	PUNCT
ajlm-463	44	12	neelsen	neelsen	NOUN
ajlm-463	44	13	stain	stain	NOUN
ajlm-463	44	14	(	(	PUNCT
ajlm-463	44	15	becton	becton	PROPN
ajlm-463	44	16	,	,	PUNCT
ajlm-463	44	17	dickinson	dickinson	PROPN
ajlm-463	44	18	&	&	CCONJ
ajlm-463	44	19	company	company	PROPN
ajlm-463	44	20	,	,	PUNCT
ajlm-463	44	21	sparks	spark	VERB
ajlm-463	44	22	,	,	PUNCT
ajlm-463	44	23	maryland	maryland	PROPN
ajlm-463	44	24	,	,	PUNCT
ajlm-463	44	25	united	united	PROPN
ajlm-463	44	26	states	states	PROPN
ajlm-463	44	27	)	)	PUNCT
ajlm-463	44	28	and	and	CCONJ
ajlm-463	44	29	examined	examine	VERB
ajlm-463	44	30	for	for	ADP
ajlm-463	44	31	acid	acid	NOUN
ajlm-463	44	32	-	-	PUNCT
ajlm-463	44	33	fast	fast	ADJ
ajlm-463	44	34	bacilli	bacilli	NOUN
ajlm-463	44	35	.	.	PUNCT
ajlm-463	45	1	determination	determination	NOUN
ajlm-463	45	2	of	of	ADP
ajlm-463	45	3	eligibility	eligibility	NOUN
ajlm-463	45	4	for	for	ADP
ajlm-463	45	5	dna	dna	NOUN
ajlm-463	45	6	sequencing	sequencing	NOUN
ajlm-463	45	7	was	be	AUX
ajlm-463	45	8	dependent	dependent	ADJ
ajlm-463	45	9	on	on	ADP
ajlm-463	45	10	results	result	NOUN
ajlm-463	45	11	from	from	ADP
ajlm-463	45	12	the	the	DET
ajlm-463	45	13	xpert	xpert	PROPN
ajlm-463	45	14	mtb	mtb	PROPN
ajlm-463	45	15	/	/	SYM
ajlm-463	45	16	rif	rif	PROPN
ajlm-463	45	17	assay	assay	PROPN
ajlm-463	45	18	(	(	PUNCT
ajlm-463	45	19	software	software	NOUN
ajlm-463	45	20	version	version	NOUN
ajlm-463	45	21	g4	g4	NOUN
ajlm-463	45	22	)	)	PUNCT
ajlm-463	45	23	.	.	PUNCT
ajlm-463	46	1	dna	dna	PROPN
ajlm-463	46	2	was	be	AUX
ajlm-463	46	3	extracted	extract	VERB
ajlm-463	46	4	from	from	ADP
ajlm-463	46	5	corresponding	correspond	VERB
ajlm-463	46	6	mgit	mgit	ADJ
ajlm-463	46	7	cultures	culture	NOUN
ajlm-463	46	8	if	if	SCONJ
ajlm-463	46	9	rifampicin	rifampicin	VERB
ajlm-463	46	10	resistance	resistance	NOUN
ajlm-463	46	11	was	be	AUX
ajlm-463	46	12	detected	detect	VERB
ajlm-463	46	13	by	by	ADP
ajlm-463	46	14	xpert	xpert	PROPN
ajlm-463	46	15	mtb	mtb	PROPN
ajlm-463	46	16	/	/	SYM
ajlm-463	46	17	rif	rif	PROPN
ajlm-463	46	18	.	.	PUNCT
ajlm-463	47	1	xpert	xpert	PROPN
ajlm-463	47	2	mtb	mtb	PROPN
ajlm-463	47	3	/	/	SYM
ajlm-463	47	4	rif	rif	PROPN
ajlm-463	47	5	assay	assay	NOUN
ajlm-463	47	6	samples	sample	NOUN
ajlm-463	47	7	(	(	PUNCT
ajlm-463	47	8	n	n	NOUN
ajlm-463	47	9	=	=	SYM
ajlm-463	47	10	995	995	NUM
ajlm-463	47	11	)	)	PUNCT
ajlm-463	47	12	were	be	AUX
ajlm-463	47	13	processed	process	VERB
ajlm-463	47	14	as	as	ADP
ajlm-463	47	15	per	per	ADP
ajlm-463	47	16	the	the	DET
ajlm-463	47	17	manufacturer	manufacturer	NOUN
ajlm-463	47	18	’s	’s	PART
ajlm-463	47	19	instructions	instruction	NOUN
ajlm-463	47	20	.	.	PUNCT
ajlm-463	48	1	a	a	DET
ajlm-463	48	2	sample	sample	NOUN
ajlm-463	48	3	reagent	reagent	ADJ
ajlm-463	48	4	buffer	buffer	NOUN
ajlm-463	48	5	was	be	AUX
ajlm-463	48	6	added	add	VERB
ajlm-463	48	7	to	to	ADP
ajlm-463	48	8	500	500	NUM
ajlm-463	48	9	µl	µl	NOUN
ajlm-463	48	10	of	of	ADP
ajlm-463	48	11	the	the	DET
ajlm-463	48	12	re	re	ADJ
ajlm-463	48	13	-	-	VERB
ajlm-463	48	14	suspended	suspend	VERB
ajlm-463	48	15	pellet	pellet	NOUN
ajlm-463	48	16	in	in	ADP
ajlm-463	48	17	the	the	DET
ajlm-463	48	18	ratio	ratio	NOUN
ajlm-463	48	19	of	of	ADP
ajlm-463	48	20	3:1	3:1	NUM
ajlm-463	48	21	(	(	PUNCT
ajlm-463	48	22	sample	sample	NOUN
ajlm-463	48	23	reagent	reagent	ADJ
ajlm-463	48	24	buffer	buffer	NOUN
ajlm-463	48	25	:	:	PUNCT
ajlm-463	48	26	specimen	speciman	NOUN
ajlm-463	48	27	)	)	PUNCT
ajlm-463	48	28	as	as	SCONJ
ajlm-463	48	29	described	describe	VERB
ajlm-463	48	30	previously.24	previously.24	NOUN
ajlm-463	48	31	the	the	DET
ajlm-463	48	32	container	container	NOUN
ajlm-463	48	33	was	be	AUX
ajlm-463	48	34	closed	close	VERB
ajlm-463	48	35	tightly	tightly	ADV
ajlm-463	48	36	and	and	CCONJ
ajlm-463	48	37	then	then	ADV
ajlm-463	48	38	vigorously	vigorously	ADV
ajlm-463	48	39	shaken	shake	VERB
ajlm-463	48	40	for	for	ADP
ajlm-463	48	41	15	15	NUM
ajlm-463	48	42	seconds	second	NOUN
ajlm-463	48	43	.	.	PUNCT
ajlm-463	49	1	the	the	DET
ajlm-463	49	2	mixed	mixed	ADJ
ajlm-463	49	3	specimen	speciman	NOUN
ajlm-463	49	4	was	be	AUX
ajlm-463	49	5	left	leave	VERB
ajlm-463	49	6	to	to	PART
ajlm-463	49	7	stand	stand	VERB
ajlm-463	49	8	for	for	ADP
ajlm-463	49	9	10	10	NUM
ajlm-463	49	10	minutes	minute	NOUN
ajlm-463	49	11	followed	follow	VERB
ajlm-463	49	12	by	by	ADP
ajlm-463	49	13	another	another	DET
ajlm-463	49	14	vigorous	vigorous	ADJ
ajlm-463	49	15	shaking	shake	VERB
ajlm-463	49	16	for	for	ADP
ajlm-463	49	17	15	15	NUM
ajlm-463	49	18	seconds	second	NOUN
ajlm-463	49	19	and	and	CCONJ
ajlm-463	49	20	left	leave	VERB
ajlm-463	49	21	to	to	PART
ajlm-463	49	22	stand	stand	VERB
ajlm-463	49	23	for	for	ADP
ajlm-463	49	24	a	a	DET
ajlm-463	49	25	further	further	ADJ
ajlm-463	49	26	five	five	NUM
ajlm-463	49	27	minutes	minute	NOUN
ajlm-463	49	28	.	.	PUNCT
ajlm-463	50	1	thereafter	thereafter	ADV
ajlm-463	50	2	,	,	PUNCT
ajlm-463	50	3	2	2	NUM
ajlm-463	50	4	ml	ml	NOUN
ajlm-463	50	5	of	of	ADP
ajlm-463	50	6	the	the	DET
ajlm-463	50	7	mixed	mixed	ADJ
ajlm-463	50	8	specimen	speciman	NOUN
ajlm-463	50	9	was	be	AUX
ajlm-463	50	10	loaded	load	VERB
ajlm-463	50	11	into	into	ADP
ajlm-463	50	12	a	a	DET
ajlm-463	50	13	single	single	ADJ
ajlm-463	50	14	-	-	PUNCT
ajlm-463	50	15	use	use	NOUN
ajlm-463	50	16	xpert	xpert	PROPN
ajlm-463	50	17	mtb	mtb	PROPN
ajlm-463	50	18	/	/	SYM
ajlm-463	50	19	rif	rif	PROPN
ajlm-463	50	20	cartridge	cartridge	NOUN
ajlm-463	50	21	.	.	PUNCT
ajlm-463	51	1	the	the	DET
ajlm-463	51	2	closed	closed	ADJ
ajlm-463	51	3	cartridge	cartridge	NOUN
ajlm-463	51	4	was	be	AUX
ajlm-463	51	5	loaded	load	VERB
ajlm-463	51	6	into	into	ADP
ajlm-463	51	7	the	the	DET
ajlm-463	51	8	genexpert	genexpert	ADJ
ajlm-463	51	9	®	®	NOUN
ajlm-463	51	10	instrument	instrument	NOUN
ajlm-463	51	11	,	,	PUNCT
ajlm-463	51	12	where	where	SCONJ
ajlm-463	51	13	extraction	extraction	NOUN
ajlm-463	51	14	,	,	PUNCT
ajlm-463	51	15	amplification	amplification	NOUN
ajlm-463	51	16	and	and	CCONJ
ajlm-463	51	17	detection	detection	NOUN
ajlm-463	51	18	of	of	ADP
ajlm-463	51	19	m.	m.	NOUN
ajlm-463	51	20	tuberculosis	tuberculosis	NOUN
ajlm-463	51	21	and	and	CCONJ
ajlm-463	51	22	screening	screen	VERB
ajlm-463	51	23	for	for	ADP
ajlm-463	51	24	resistance	resistance	NOUN
ajlm-463	51	25	to	to	ADP
ajlm-463	51	26	rifampicin	rifampicin	VERB
ajlm-463	51	27	were	be	AUX
ajlm-463	51	28	performed	perform	VERB
ajlm-463	51	29	automatically	automatically	ADV
ajlm-463	51	30	and	and	CCONJ
ajlm-463	51	31	simultaneously	simultaneously	ADV
ajlm-463	51	32	.	.	PUNCT
ajlm-463	52	1	results	result	NOUN
ajlm-463	52	2	were	be	AUX
ajlm-463	52	3	available	available	ADJ
ajlm-463	52	4	within	within	ADP
ajlm-463	52	5	two	two	NUM
ajlm-463	52	6	hours	hour	NOUN
ajlm-463	52	7	.	.	PUNCT
ajlm-463	53	1	the	the	DET
ajlm-463	53	2	xpert	xpert	PROPN
ajlm-463	53	3	mtb	mtb	PROPN
ajlm-463	53	4	/	/	SYM
ajlm-463	53	5	rif	rif	PROPN
ajlm-463	53	6	probe	probe	NOUN
ajlm-463	53	7	and	and	CCONJ
ajlm-463	53	8	cycle	cycle	NOUN
ajlm-463	53	9	threshold	threshold	NOUN
ajlm-463	53	10	(	(	PUNCT
ajlm-463	53	11	ct	ct	NOUN
ajlm-463	53	12	)	)	PUNCT
ajlm-463	53	13	value	value	NOUN
ajlm-463	53	14	was	be	AUX
ajlm-463	53	15	documented	document	VERB
ajlm-463	53	16	for	for	ADP
ajlm-463	53	17	each	each	DET
ajlm-463	53	18	tuberculosis	tuberculosis	NOUN
ajlm-463	53	19	strain	strain	NOUN
ajlm-463	53	20	that	that	PRON
ajlm-463	53	21	was	be	AUX
ajlm-463	53	22	detected	detect	VERB
ajlm-463	53	23	as	as	ADP
ajlm-463	53	24	resistant	resistant	ADJ
ajlm-463	53	25	to	to	ADP
ajlm-463	53	26	rifampicin	rifampicin	VERB
ajlm-463	53	27	.	.	PUNCT
ajlm-463	54	1	dna	dna	PROPN
ajlm-463	54	2	extraction	extraction	NOUN
ajlm-463	54	3	and	and	CCONJ
ajlm-463	54	4	amplification	amplification	NOUN
ajlm-463	54	5	genomic	genomic	NOUN
ajlm-463	54	6	bacterial	bacterial	ADJ
ajlm-463	54	7	dna	dna	NOUN
ajlm-463	54	8	was	be	AUX
ajlm-463	54	9	extracted	extract	VERB
ajlm-463	54	10	from	from	ADP
ajlm-463	54	11	cultures	culture	NOUN
ajlm-463	54	12	at	at	ADP
ajlm-463	54	13	the	the	DET
ajlm-463	54	14	unc	unc	PROPN
ajlm-463	54	15	laboratory	laboratory	NOUN
ajlm-463	54	16	using	use	VERB
ajlm-463	54	17	the	the	DET
ajlm-463	54	18	hain	hain	NOUN
ajlm-463	54	19	genolyse	genolyse	PROPN
ajlm-463	54	20	kit	kit	PROPN
ajlm-463	54	21	(	(	PUNCT
ajlm-463	54	22	hain	hain	PROPN
ajlm-463	54	23	lifescience	lifescience	PROPN
ajlm-463	54	24	gmbh	gmbh	PROPN
ajlm-463	54	25	,	,	PUNCT
ajlm-463	54	26	nehren	nehren	PROPN
ajlm-463	54	27	,	,	PUNCT
ajlm-463	54	28	germany	germany	PROPN
ajlm-463	54	29	)	)	PUNCT
ajlm-463	54	30	.	.	PUNCT
ajlm-463	55	1	from	from	ADP
ajlm-463	55	2	mgit	mgit	ADJ
ajlm-463	55	3	liquid	liquid	ADJ
ajlm-463	55	4	media	medium	NOUN
ajlm-463	55	5	,	,	PUNCT
ajlm-463	55	6	1.0	1.0	NUM
ajlm-463	55	7	ml	ml	NOUN
ajlm-463	55	8	was	be	AUX
ajlm-463	55	9	transferred	transfer	VERB
ajlm-463	55	10	to	to	ADP
ajlm-463	55	11	a	a	DET
ajlm-463	55	12	sarstedt	sarstedt	NOUN
ajlm-463	55	13	micro	micro	NOUN
ajlm-463	55	14	-	-	NOUN
ajlm-463	55	15	centrifuge	centrifuge	ADJ
ajlm-463	55	16	tube	tube	NOUN
ajlm-463	55	17	.	.	PUNCT
ajlm-463	56	1	the	the	DET
ajlm-463	56	2	tube	tube	NOUN
ajlm-463	56	3	was	be	AUX
ajlm-463	56	4	centrifuged	centrifuge	VERB
ajlm-463	56	5	for	for	ADP
ajlm-463	56	6	15	15	NUM
ajlm-463	56	7	minutes	minute	NOUN
ajlm-463	56	8	at	at	ADP
ajlm-463	56	9	14	14	NUM
ajlm-463	56	10	000	000	NUM
ajlm-463	56	11	rpm	rpm	NOUN
ajlm-463	56	12	.	.	PUNCT
ajlm-463	57	1	the	the	DET
ajlm-463	57	2	supernatant	supernatant	NOUN
ajlm-463	57	3	was	be	AUX
ajlm-463	57	4	carefully	carefully	ADV
ajlm-463	57	5	discarded	discard	VERB
ajlm-463	57	6	and	and	CCONJ
ajlm-463	57	7	the	the	DET
ajlm-463	57	8	pellet	pellet	NOUN
ajlm-463	57	9	was	be	AUX
ajlm-463	57	10	re	re	VERB
ajlm-463	57	11	-	-	VERB
ajlm-463	57	12	suspended	suspend	VERB
ajlm-463	57	13	in	in	ADP
ajlm-463	57	14	100	100	NUM
ajlm-463	57	15	µl	µl	ADP
ajlm-463	57	16	lysis	lysis	NOUN
ajlm-463	57	17	buffer	buffer	NOUN
ajlm-463	57	18	from	from	ADP
ajlm-463	57	19	the	the	DET
ajlm-463	57	20	kit	kit	NOUN
ajlm-463	57	21	,	,	PUNCT
ajlm-463	57	22	vortexed	vortexe	VERB
ajlm-463	57	23	thoroughly	thoroughly	ADV
ajlm-463	57	24	and	and	CCONJ
ajlm-463	57	25	incubated	incubate	VERB
ajlm-463	57	26	at	at	ADP
ajlm-463	57	27	95	95	NUM
ajlm-463	57	28	°	°	ADP
ajlm-463	57	29	c	c	NOUN
ajlm-463	57	30	in	in	ADP
ajlm-463	57	31	a	a	DET
ajlm-463	57	32	heating	heating	NOUN
ajlm-463	57	33	block	block	NOUN
ajlm-463	57	34	for	for	ADP
ajlm-463	57	35	five	five	NUM
ajlm-463	57	36	minutes	minute	NOUN
ajlm-463	57	37	.	.	PUNCT
ajlm-463	58	1	tubes	tube	NOUN
ajlm-463	58	2	were	be	AUX
ajlm-463	58	3	removed	remove	VERB
ajlm-463	58	4	and	and	CCONJ
ajlm-463	58	5	briefly	briefly	ADV
ajlm-463	58	6	centrifuged	centrifuge	VERB
ajlm-463	58	7	to	to	PART
ajlm-463	58	8	remove	remove	VERB
ajlm-463	58	9	condensation	condensation	NOUN
ajlm-463	58	10	.	.	PUNCT
ajlm-463	59	1	to	to	ADP
ajlm-463	59	2	each	each	DET
ajlm-463	59	3	tube	tube	NOUN
ajlm-463	59	4	,	,	PUNCT
ajlm-463	59	5	100	100	NUM
ajlm-463	59	6	µl	µl	ADP
ajlm-463	59	7	of	of	ADP
ajlm-463	59	8	neutralization	neutralization	NOUN
ajlm-463	59	9	buffer	buffer	NOUN
ajlm-463	59	10	was	be	AUX
ajlm-463	59	11	added	add	VERB
ajlm-463	59	12	,	,	PUNCT
ajlm-463	59	13	vortexed	vortexe	VERB
ajlm-463	59	14	for	for	ADP
ajlm-463	59	15	five	five	NUM
ajlm-463	59	16	seconds	second	NOUN
ajlm-463	59	17	and	and	CCONJ
ajlm-463	59	18	then	then	ADV
ajlm-463	59	19	centrifuged	centrifuge	VERB
ajlm-463	59	20	for	for	ADP
ajlm-463	59	21	five	five	NUM
ajlm-463	59	22	minutes	minute	NOUN
ajlm-463	59	23	at	at	ADP
ajlm-463	59	24	14	14	NUM
ajlm-463	59	25	000	000	NUM
ajlm-463	59	26	rpm	rpm	NOUN
ajlm-463	59	27	.	.	PUNCT
ajlm-463	60	1	supernatant	supernatant	PROPN
ajlm-463	60	2	was	be	AUX
ajlm-463	60	3	transferred	transfer	VERB
ajlm-463	60	4	to	to	ADP
ajlm-463	60	5	a	a	DET
ajlm-463	60	6	new	new	ADJ
ajlm-463	60	7	tube	tube	NOUN
ajlm-463	60	8	and	and	CCONJ
ajlm-463	60	9	the	the	DET
ajlm-463	60	10	pellet	pellet	NOUN
ajlm-463	60	11	was	be	AUX
ajlm-463	60	12	discarded	discard	VERB
ajlm-463	60	13	.	.	PUNCT
ajlm-463	61	1	the	the	DET
ajlm-463	61	2	extracted	extract	VERB
ajlm-463	61	3	dna	dna	NOUN
ajlm-463	61	4	was	be	AUX
ajlm-463	61	5	stored	store	VERB
ajlm-463	61	6	at	at	ADP
ajlm-463	61	7	-80	-80	NOUN
ajlm-463	61	8	°	°	ADP
ajlm-463	61	9	c	c	NOUN
ajlm-463	61	10	for	for	ADP
ajlm-463	61	11	use	use	NOUN
ajlm-463	61	12	as	as	ADP
ajlm-463	61	13	dna	dna	NOUN
ajlm-463	61	14	template	template	NOUN
ajlm-463	61	15	.	.	PUNCT
ajlm-463	62	1	mtbdrplus	mtbdrplus	ADJ
ajlm-463	62	2	line	line	NOUN
ajlm-463	62	3	probe	probe	NOUN
ajlm-463	62	4	assay	assay	VERB
ajlm-463	62	5	the	the	DET
ajlm-463	62	6	genotype	genotype	NOUN
ajlm-463	62	7	®	®	NOUN
ajlm-463	62	8	mtbdrplus	mtbdrplus	ADJ
ajlm-463	62	9	line	line	NOUN
ajlm-463	62	10	probe	probe	NOUN
ajlm-463	62	11	assay	assay	NOUN
ajlm-463	62	12	(	(	PUNCT
ajlm-463	62	13	version	version	NOUN
ajlm-463	62	14	2	2	NUM
ajlm-463	62	15	)	)	PUNCT
ajlm-463	62	16	was	be	AUX
ajlm-463	62	17	performed	perform	VERB
ajlm-463	62	18	according	accord	VERB
ajlm-463	62	19	to	to	ADP
ajlm-463	62	20	the	the	DET
ajlm-463	62	21	manufacturer	manufacturer	NOUN
ajlm-463	62	22	’s	’s	PART
ajlm-463	62	23	instructions	instruction	NOUN
ajlm-463	62	24	.	.	PUNCT
ajlm-463	63	1	in	in	ADP
ajlm-463	63	2	brief	brief	NOUN
ajlm-463	63	3	,	,	PUNCT
ajlm-463	63	4	an	an	DET
ajlm-463	63	5	appropriate	appropriate	ADJ
ajlm-463	63	6	number	number	NOUN
ajlm-463	63	7	of	of	ADP
ajlm-463	63	8	pcr	pcr	PROPN
ajlm-463	63	9	tubes	tube	NOUN
ajlm-463	63	10	,	,	PUNCT
ajlm-463	63	11	one	one	NUM
ajlm-463	63	12	for	for	ADP
ajlm-463	63	13	each	each	DET
ajlm-463	63	14	sample	sample	NOUN
ajlm-463	63	15	and	and	CCONJ
ajlm-463	63	16	one	one	NUM
ajlm-463	63	17	each	each	DET
ajlm-463	63	18	for	for	ADP
ajlm-463	63	19	a	a	DET
ajlm-463	63	20	pcr	pcr	ADJ
ajlm-463	63	21	positive	positive	ADJ
ajlm-463	63	22	(	(	PUNCT
ajlm-463	63	23	m.	m.	NOUN
ajlm-463	63	24	tuberculosis	tuberculosis	NOUN
ajlm-463	63	25	dna	dna	PROPN
ajlm-463	63	26	)	)	PUNCT
ajlm-463	63	27	and	and	CCONJ
ajlm-463	63	28	negative	negative	ADJ
ajlm-463	63	29	(	(	PUNCT
ajlm-463	63	30	dh2o	dh2o	NOUN
ajlm-463	63	31	)	)	PUNCT
ajlm-463	63	32	control	control	NOUN
ajlm-463	63	33	were	be	AUX
ajlm-463	63	34	labelled	label	VERB
ajlm-463	63	35	.	.	PUNCT
ajlm-463	64	1	a	a	DET
ajlm-463	64	2	master	master	NOUN
ajlm-463	64	3	mix	mix	NOUN
ajlm-463	64	4	was	be	AUX
ajlm-463	64	5	prepared	prepare	VERB
ajlm-463	64	6	for	for	ADP
ajlm-463	64	7	one	one	NUM
ajlm-463	64	8	reaction	reaction	NOUN
ajlm-463	64	9	and	and	CCONJ
ajlm-463	64	10	the	the	DET
ajlm-463	64	11	final	final	ADJ
ajlm-463	64	12	volume	volume	NOUN
ajlm-463	64	13	adjusted	adjust	VERB
ajlm-463	64	14	according	accord	VERB
ajlm-463	64	15	to	to	ADP
ajlm-463	64	16	the	the	DET
ajlm-463	64	17	total	total	ADJ
ajlm-463	64	18	number	number	NOUN
ajlm-463	64	19	of	of	ADP
ajlm-463	64	20	samples	sample	NOUN
ajlm-463	64	21	,	,	PUNCT
ajlm-463	64	22	with	with	SCONJ
ajlm-463	64	23	some	some	DET
ajlm-463	64	24	excess	excess	NOUN
ajlm-463	64	25	to	to	PART
ajlm-463	64	26	allow	allow	VERB
ajlm-463	64	27	for	for	ADP
ajlm-463	64	28	pipetting	pipette	VERB
ajlm-463	64	29	errors	error	NOUN
ajlm-463	64	30	.	.	PUNCT
ajlm-463	65	1	the	the	DET
ajlm-463	65	2	solution	solution	NOUN
ajlm-463	65	3	was	be	AUX
ajlm-463	65	4	mixed	mix	VERB
ajlm-463	65	5	by	by	ADP
ajlm-463	65	6	inversion	inversion	NOUN
ajlm-463	65	7	and	and	CCONJ
ajlm-463	65	8	an	an	DET
ajlm-463	65	9	aliquot	aliquot	NOUN
ajlm-463	65	10	of	of	ADP
ajlm-463	65	11	45	45	NUM
ajlm-463	65	12	µl	µl	NOUN
ajlm-463	65	13	of	of	ADP
ajlm-463	65	14	the	the	DET
ajlm-463	65	15	prepared	prepare	VERB
ajlm-463	65	16	master	master	NOUN
ajlm-463	65	17	mix	mix	NOUN
ajlm-463	65	18	was	be	AUX
ajlm-463	65	19	transferred	transfer	VERB
ajlm-463	65	20	to	to	ADP
ajlm-463	65	21	each	each	DET
ajlm-463	65	22	pcr	pcr	ADJ
ajlm-463	65	23	tube	tube	NOUN
ajlm-463	65	24	.	.	PUNCT
ajlm-463	66	1	5	5	NUM
ajlm-463	66	2	µl	µl	NOUN
ajlm-463	66	3	of	of	ADP
ajlm-463	66	4	each	each	DET
ajlm-463	66	5	sample	sample	NOUN
ajlm-463	66	6	or	or	CCONJ
ajlm-463	66	7	control	control	NOUN
ajlm-463	66	8	dna	dna	PROPN
ajlm-463	66	9	was	be	AUX
ajlm-463	66	10	added	add	VERB
ajlm-463	66	11	to	to	ADP
ajlm-463	66	12	the	the	DET
ajlm-463	66	13	appropriate	appropriate	ADJ
ajlm-463	66	14	pcr	pcr	ADJ
ajlm-463	66	15	tube	tube	NOUN
ajlm-463	66	16	.	.	PUNCT
ajlm-463	67	1	pcr	pcr	PROPN
ajlm-463	67	2	was	be	AUX
ajlm-463	67	3	performed	perform	VERB
ajlm-463	67	4	in	in	ADP
ajlm-463	67	5	a	a	DET
ajlm-463	67	6	9700	9700	NUM
ajlm-463	67	7	dna	dna	PROPN
ajlm-463	67	8	thermocycler	thermocycler	NOUN
ajlm-463	67	9	(	(	PUNCT
ajlm-463	67	10	applied	apply	VERB
ajlm-463	67	11	biosystems	biosystem	NOUN
ajlm-463	67	12	,	,	PUNCT
ajlm-463	67	13	foster	foster	ADJ
ajlm-463	67	14	city	city	NOUN
ajlm-463	67	15	,	,	PUNCT
ajlm-463	67	16	california	california	PROPN
ajlm-463	67	17	,	,	PUNCT
ajlm-463	67	18	united	united	PROPN
ajlm-463	67	19	states	states	PROPN
ajlm-463	67	20	)	)	PUNCT
ajlm-463	67	21	,	,	PUNCT
ajlm-463	67	22	using	use	VERB
ajlm-463	67	23	the	the	DET
ajlm-463	67	24	cycling	cycling	NOUN
ajlm-463	67	25	protocol	protocol	NOUN
ajlm-463	67	26	as	as	SCONJ
ajlm-463	67	27	described	describe	VERB
ajlm-463	67	28	by	by	ADP
ajlm-463	67	29	the	the	DET
ajlm-463	67	30	manufacturer	manufacturer	NOUN
ajlm-463	67	31	.	.	PUNCT
ajlm-463	68	1	dna	dna	PROPN
ajlm-463	68	2	pcr	pcr	ADJ
ajlm-463	68	3	pcr	pcr	ADJ
ajlm-463	68	4	amplification	amplification	NOUN
ajlm-463	68	5	of	of	ADP
ajlm-463	68	6	the	the	DET
ajlm-463	68	7	rpob	rpob	PROPN
ajlm-463	68	8	gene	gene	NOUN
ajlm-463	68	9	,	,	PUNCT
ajlm-463	68	10	which	which	PRON
ajlm-463	68	11	included	include	VERB
ajlm-463	68	12	the	the	DET
ajlm-463	68	13	rrdr	rrdr	NOUN
ajlm-463	68	14	,	,	PUNCT
ajlm-463	68	15	was	be	AUX
ajlm-463	68	16	carried	carry	VERB
ajlm-463	68	17	out	out	ADP
ajlm-463	68	18	using	use	VERB
ajlm-463	68	19	forward	forward	ADJ
ajlm-463	68	20	primer	primer	NOUN
ajlm-463	68	21	rpobf2	rpobf2	NOUN
ajlm-463	68	22	(	(	PUNCT
ajlm-463	68	23	5’-gag	5’-gag	NUM
ajlm-463	68	24	ggt	ggt	PROPN
ajlm-463	68	25	cag	cag	AUX
ajlm-463	68	26	acc	acc	PROPN
ajlm-463	68	27	acg	acg	PROPN
ajlm-463	68	28	atg	atg	PROPN
ajlm-463	68	29	ac-3	ac-3	PROPN
ajlm-463	68	30	’	'	PUNCT
ajlm-463	68	31	;	;	PUNCT
ajlm-463	68	32	nucleotide	nucleotide	NOUN
ajlm-463	68	33	positions	position	NOUN
ajlm-463	68	34	1030	1030	NUM
ajlm-463	68	35	to	to	ADP
ajlm-463	68	36	1049	1049	NUM
ajlm-463	68	37	according	accord	VERB
ajlm-463	68	38	to	to	ADP
ajlm-463	68	39	h37rv	h37rv	PROPN
ajlm-463	68	40	numbering	numbering	NOUN
ajlm-463	68	41	,	,	PUNCT
ajlm-463	68	42	genbank	genbank	NOUN
ajlm-463	68	43	accession	accession	NOUN
ajlm-463	68	44	number	number	NOUN
ajlm-463	68	45	cab09390.1	cab09390.1	NOUN
ajlm-463	68	46	)	)	PUNCT
ajlm-463	68	47	and	and	CCONJ
ajlm-463	68	48	reverse	reverse	ADJ
ajlm-463	68	49	primer	primer	NOUN
ajlm-463	68	50	rpobr	rpobr	NOUN
ajlm-463	68	51	(	(	PUNCT
ajlm-463	68	52	5’-gag	5’-gag	NUM
ajlm-463	68	53	ccg	ccg	PROPN
ajlm-463	68	54	atc	atc	PROPN
ajlm-463	68	55	aga	aga	PROPN
ajlm-463	68	56	ccg	ccg	PROPN
ajlm-463	68	57	atg	atg	PROPN
ajlm-463	68	58	t-3	t-3	PROPN
ajlm-463	68	59	’	'	PUNCT
ajlm-463	68	60	;	;	PUNCT
ajlm-463	68	61	nucleotide	nucleotide	NOUN
ajlm-463	68	62	positions	position	NOUN
ajlm-463	68	63	1460	1460	NUM
ajlm-463	68	64	to	to	ADP
ajlm-463	68	65	1478	1478	NUM
ajlm-463	68	66	according	accord	VERB
ajlm-463	68	67	to	to	ADP
ajlm-463	68	68	h37rv	h37rv	ADP
ajlm-463	68	69	numbering	numbering	NOUN
ajlm-463	68	70	)	)	PUNCT
ajlm-463	68	71	in	in	ADP
ajlm-463	68	72	a	a	DET
ajlm-463	68	73	geneamp	geneamp	ADJ
ajlm-463	68	74	pcr	pcr	NOUN
ajlm-463	68	75	system	system	NOUN
ajlm-463	68	76	9700	9700	NUM
ajlm-463	68	77	thermocycler	thermocycler	NOUN
ajlm-463	68	78	(	(	PUNCT
ajlm-463	68	79	applied	apply	VERB
ajlm-463	68	80	biosystems	biosystem	NOUN
ajlm-463	68	81	,	,	PUNCT
ajlm-463	68	82	foster	foster	ADJ
ajlm-463	68	83	city	city	NOUN
ajlm-463	68	84	,	,	PUNCT
ajlm-463	68	85	california	california	PROPN
ajlm-463	68	86	,	,	PUNCT
ajlm-463	68	87	united	united	PROPN
ajlm-463	68	88	states	states	PROPN
ajlm-463	68	89	)	)	PUNCT
ajlm-463	68	90	.	.	PUNCT
ajlm-463	69	1	the	the	DET
ajlm-463	69	2	total	total	ADJ
ajlm-463	69	3	volume	volume	NOUN
ajlm-463	69	4	of	of	ADP
ajlm-463	69	5	the	the	DET
ajlm-463	69	6	pcr	pcr	ADJ
ajlm-463	69	7	reaction	reaction	NOUN
ajlm-463	69	8	used	use	VERB
ajlm-463	69	9	was	be	AUX
ajlm-463	69	10	50	50	NUM
ajlm-463	69	11	µl	µl	NOUN
ajlm-463	69	12	,	,	PUNCT
ajlm-463	69	13	containing	contain	VERB
ajlm-463	69	14	:	:	PUNCT
ajlm-463	69	15	5	5	NUM
ajlm-463	69	16	µl	µl	ADP
ajlm-463	69	17	of	of	ADP
ajlm-463	69	18	10x	10x	X
ajlm-463	69	19	high	high	ADJ
ajlm-463	69	20	fidelity	fidelity	NOUN
ajlm-463	69	21	buffer	buffer	NOUN
ajlm-463	69	22	,	,	PUNCT
ajlm-463	69	23	1	1	NUM
ajlm-463	69	24	µl	µl	ADP
ajlm-463	69	25	of	of	ADP
ajlm-463	69	26	10	10	NUM
ajlm-463	69	27	mm	mm	NUM
ajlm-463	69	28	dntp	dntp	NOUN
ajlm-463	69	29	mix	mix	NOUN
ajlm-463	69	30	,	,	PUNCT
ajlm-463	69	31	2	2	NUM
ajlm-463	69	32	µl	µl	NOUN
ajlm-463	69	33	of	of	ADP
ajlm-463	69	34	50	50	NUM
ajlm-463	69	35	mm	mm	NOUN
ajlm-463	69	36	mgso4	mgso4	PROPN
ajlm-463	69	37	,	,	PUNCT
ajlm-463	69	38	1	1	NUM
ajlm-463	69	39	µl	µl	ADP
ajlm-463	69	40	of	of	ADP
ajlm-463	69	41	each	each	DET
ajlm-463	69	42	primer	primer	NOUN
ajlm-463	69	43	,	,	PUNCT
ajlm-463	69	44	0.2	0.2	NUM
ajlm-463	69	45	µl	µl	NOUN
ajlm-463	69	46	of	of	ADP
ajlm-463	69	47	taq	taq	PROPN
ajlm-463	69	48	hifi	hifi	PROPN
ajlm-463	69	49	(	(	PUNCT
ajlm-463	69	50	invitrogen	invitrogen	PROPN
ajlm-463	69	51	,	,	PUNCT
ajlm-463	69	52	carlsbad	carlsbad	PROPN
ajlm-463	69	53	,	,	PUNCT
ajlm-463	69	54	california	california	PROPN
ajlm-463	69	55	,	,	PUNCT
ajlm-463	69	56	united	united	PROPN
ajlm-463	69	57	states	states	PROPN
ajlm-463	69	58	)	)	PUNCT
ajlm-463	69	59	,	,	PUNCT
ajlm-463	69	60	36.8	36.8	NUM
ajlm-463	69	61	µl	µl	NOUN
ajlm-463	69	62	of	of	ADP
ajlm-463	69	63	molecular	molecular	ADJ
ajlm-463	69	64	grade	grade	NOUN
ajlm-463	69	65	water	water	NOUN
ajlm-463	69	66	and	and	CCONJ
ajlm-463	69	67	3	3	NUM
ajlm-463	69	68	µl	µl	NOUN
ajlm-463	69	69	of	of	ADP
ajlm-463	69	70	extracted	extract	VERB
ajlm-463	69	71	genomic	genomic	ADJ
ajlm-463	69	72	dna	dna	NOUN
ajlm-463	69	73	.	.	PUNCT
ajlm-463	70	1	amplification	amplification	NOUN
ajlm-463	70	2	conditions	condition	NOUN
ajlm-463	70	3	were	be	AUX
ajlm-463	70	4	set	set	VERB
ajlm-463	70	5	at	at	ADP
ajlm-463	70	6	:	:	PUNCT
ajlm-463	70	7	94	94	NUM
ajlm-463	70	8	°	°	ADP
ajlm-463	70	9	c	c	NOUN
ajlm-463	70	10	for	for	ADP
ajlm-463	70	11	two	two	NUM
ajlm-463	70	12	minutes	minute	NOUN
ajlm-463	70	13	;	;	PUNCT
ajlm-463	70	14	followed	follow	VERB
ajlm-463	70	15	by	by	ADP
ajlm-463	70	16	35	35	NUM
ajlm-463	70	17	cycles	cycle	NOUN
ajlm-463	70	18	of	of	ADP
ajlm-463	70	19	94	94	NUM
ajlm-463	70	20	°	°	ADP
ajlm-463	70	21	c	c	NOUN
ajlm-463	70	22	for	for	ADP
ajlm-463	70	23	30	30	NUM
ajlm-463	70	24	seconds	second	NOUN
ajlm-463	70	25	,	,	PUNCT
ajlm-463	70	26	55	55	NUM
ajlm-463	70	27	°	°	ADP
ajlm-463	70	28	c	c	NOUN
ajlm-463	70	29	for	for	ADP
ajlm-463	70	30	30	30	NUM
ajlm-463	70	31	seconds	second	NOUN
ajlm-463	70	32	,	,	PUNCT
ajlm-463	70	33	68	68	NUM
ajlm-463	70	34	°	°	ADP
ajlm-463	70	35	c	c	NOUN
ajlm-463	70	36	for	for	ADP
ajlm-463	70	37	40	40	NUM
ajlm-463	70	38	seconds	second	NOUN
ajlm-463	70	39	;	;	PUNCT
ajlm-463	70	40	followed	follow	VERB
ajlm-463	70	41	by	by	ADP
ajlm-463	70	42	a	a	DET
ajlm-463	70	43	10	10	NUM
ajlm-463	70	44	-	-	PUNCT
ajlm-463	70	45	minute	minute	NOUN
ajlm-463	70	46	final	final	ADJ
ajlm-463	70	47	elongation	elongation	NOUN
ajlm-463	70	48	at	at	ADP
ajlm-463	70	49	68	68	NUM
ajlm-463	70	50	°	°	NOUN
ajlm-463	70	51	c	c	NOUN
ajlm-463	70	52	.	.	PUNCT
ajlm-463	71	1	pcr	pcr	ADJ
ajlm-463	71	2	products	product	NOUN
ajlm-463	71	3	were	be	AUX
ajlm-463	71	4	purified	purify	VERB
ajlm-463	71	5	using	use	VERB
ajlm-463	71	6	the	the	DET
ajlm-463	71	7	genejet	genejet	NOUN
ajlm-463	71	8	pcr	pcr	PROPN
ajlm-463	71	9	purification	purification	NOUN
ajlm-463	71	10	kit	kit	NOUN
ajlm-463	71	11	(	(	PUNCT
ajlm-463	71	12	thermo	thermo	NOUN
ajlm-463	71	13	scientific	scientific	NOUN
ajlm-463	71	14	,	,	PUNCT
ajlm-463	71	15	waltham	waltham	PROPN
ajlm-463	71	16	,	,	PUNCT
ajlm-463	71	17	massachusetts	massachusetts	PROPN
ajlm-463	71	18	,	,	PUNCT
ajlm-463	71	19	united	united	PROPN
ajlm-463	71	20	states	states	PROPN
ajlm-463	71	21	)	)	PUNCT
ajlm-463	71	22	following	follow	VERB
ajlm-463	71	23	the	the	DET
ajlm-463	71	24	manufacturer	manufacturer	NOUN
ajlm-463	71	25	’s	’s	PART
ajlm-463	71	26	instructions	instruction	NOUN
ajlm-463	71	27	.	.	PUNCT
ajlm-463	72	1	5	5	NUM
ajlm-463	72	2	µl	µl	NOUN
ajlm-463	72	3	of	of	ADP
ajlm-463	72	4	the	the	DET
ajlm-463	72	5	amplified	amplify	VERB
ajlm-463	72	6	product	product	NOUN
ajlm-463	72	7	was	be	AUX
ajlm-463	72	8	visualised	visualise	VERB
ajlm-463	72	9	on	on	ADP
ajlm-463	72	10	a	a	DET
ajlm-463	72	11	1	1	NUM
ajlm-463	72	12	%	%	NOUN
ajlm-463	72	13	agarose	agarose	NOUN
ajlm-463	72	14	gel	gel	NOUN
ajlm-463	72	15	.	.	PUNCT
ajlm-463	73	1	dna	dna	PROPN
ajlm-463	73	2	sequencing	sequence	VERB
ajlm-463	73	3	dna	dna	NOUN
ajlm-463	73	4	sequencing	sequencing	NOUN
ajlm-463	73	5	was	be	AUX
ajlm-463	73	6	performed	perform	VERB
ajlm-463	73	7	in	in	ADP
ajlm-463	73	8	an	an	DET
ajlm-463	73	9	automated	automate	VERB
ajlm-463	73	10	dna	dna	NOUN
ajlm-463	73	11	sequencer	sequencer	NOUN
ajlm-463	73	12	abi	abi	PROPN
ajlm-463	73	13	3700	3700	NUM
ajlm-463	73	14	,	,	PUNCT
ajlm-463	73	15	(	(	PUNCT
ajlm-463	73	16	applied	apply	VERB
ajlm-463	73	17	biosystems	biosystem	NOUN
ajlm-463	73	18	,	,	PUNCT
ajlm-463	73	19	foster	foster	ADJ
ajlm-463	73	20	city	city	NOUN
ajlm-463	73	21	,	,	PUNCT
ajlm-463	73	22	california	california	PROPN
ajlm-463	73	23	,	,	PUNCT
ajlm-463	73	24	united	united	PROPN
ajlm-463	73	25	states	states	PROPN
ajlm-463	73	26	)	)	PUNCT
ajlm-463	73	27	using	use	VERB
ajlm-463	73	28	the	the	DET
ajlm-463	73	29	bigdye	bigdye	NOUN
ajlm-463	73	30	terminator	terminator	NOUN
ajlm-463	73	31	v3.1	v3.1	ADP
ajlm-463	73	32	sequencing	sequence	VERB
ajlm-463	73	33	kit	kit	NOUN
ajlm-463	73	34	with	with	ADP
ajlm-463	73	35	forward	forward	ADJ
ajlm-463	73	36	primer	primer	NOUN
ajlm-463	73	37	rpobs	rpob	VERB
ajlm-463	73	38	(	(	PUNCT
ajlm-463	73	39	5’-gca	5’-gca	NUM
ajlm-463	73	40	gac	gac	PROPN
ajlm-463	73	41	gtt	gtt	PROPN
ajlm-463	73	42	gat	gat	PROPN
ajlm-463	73	43	caa	caa	PROPN
ajlm-463	73	44	cat	cat	PROPN
ajlm-463	73	45	cc-3	cc-3	PROPN
ajlm-463	73	46	’	'	PUNCT
ajlm-463	73	47	)	)	PUNCT
ajlm-463	73	48	and	and	CCONJ
ajlm-463	73	49	reverse	reverse	ADJ
ajlm-463	73	50	primer	primer	NOUN
ajlm-463	73	51	rpobr	rpobr	NOUN
ajlm-463	73	52	(	(	PUNCT
ajlm-463	73	53	5’-gag	5’-gag	NUM
ajlm-463	73	54	ccg	ccg	PROPN
ajlm-463	73	55	atc	atc	PROPN
ajlm-463	73	56	aga	aga	PROPN
ajlm-463	73	57	ccg	ccg	PROPN
ajlm-463	73	58	atg	atg	PROPN
ajlm-463	73	59	t-3	t-3	PROPN
ajlm-463	73	60	’	'	PUNCT
ajlm-463	73	61	)	)	PUNCT
ajlm-463	73	62	.	.	PUNCT
ajlm-463	74	1	the	the	DET
ajlm-463	74	2	total	total	ADJ
ajlm-463	74	3	volume	volume	NOUN
ajlm-463	74	4	of	of	ADP
ajlm-463	74	5	the	the	DET
ajlm-463	74	6	sequencing	sequencing	NOUN
ajlm-463	74	7	reaction	reaction	NOUN
ajlm-463	74	8	was	be	AUX
ajlm-463	74	9	20	20	NUM
ajlm-463	74	10	µl	µl	NOUN
ajlm-463	74	11	,	,	PUNCT
ajlm-463	74	12	containing	contain	VERB
ajlm-463	74	13	:	:	PUNCT
ajlm-463	74	14	4	4	NUM
ajlm-463	74	15	µl	µl	NOUN
ajlm-463	74	16	of	of	ADP
ajlm-463	74	17	bigdye	bigdye	NOUN
ajlm-463	74	18	terminator	terminator	NOUN
ajlm-463	74	19	,	,	PUNCT
ajlm-463	74	20	2	2	NUM
ajlm-463	74	21	µl	µl	ADP
ajlm-463	74	22	of	of	ADP
ajlm-463	74	23	10x	10x	X
ajlm-463	74	24	sequencing	sequence	VERB
ajlm-463	74	25	buffer	buffer	NOUN
ajlm-463	74	26	,	,	PUNCT
ajlm-463	74	27	2	2	NUM
ajlm-463	74	28	µl	µl	NOUN
ajlm-463	74	29	of	of	ADP
ajlm-463	74	30	water	water	NOUN
ajlm-463	74	31	,	,	PUNCT
ajlm-463	74	32	1	1	NUM
ajlm-463	74	33	µl	µl	NOUN
ajlm-463	74	34	of	of	ADP
ajlm-463	74	35	primer	primer	NOUN
ajlm-463	74	36	and	and	CCONJ
ajlm-463	74	37	11	11	NUM
ajlm-463	74	38	µl	µl	NOUN
ajlm-463	74	39	of	of	ADP
ajlm-463	74	40	sample	sample	NOUN
ajlm-463	74	41	.	.	PUNCT
ajlm-463	75	1	amplification	amplification	NOUN
ajlm-463	75	2	conditions	condition	NOUN
ajlm-463	75	3	were	be	AUX
ajlm-463	75	4	set	set	VERB
ajlm-463	75	5	for	for	ADP
ajlm-463	75	6	:	:	PUNCT
ajlm-463	75	7	one	one	NUM
ajlm-463	75	8	minute	minute	NOUN
ajlm-463	75	9	at	at	ADP
ajlm-463	75	10	96	96	NUM
ajlm-463	75	11	°	°	NOUN
ajlm-463	75	12	c	c	NOUN
ajlm-463	75	13	;	;	PUNCT
ajlm-463	75	14	followed	follow	VERB
ajlm-463	75	15	by	by	ADP
ajlm-463	75	16	25	25	NUM
ajlm-463	75	17	cycles	cycle	NOUN
ajlm-463	75	18	of	of	ADP
ajlm-463	75	19	96	96	NUM
ajlm-463	75	20	°	°	NOUN
ajlm-463	75	21	c	c	NOUN
ajlm-463	75	22	for	for	ADP
ajlm-463	75	23	10	10	NUM
ajlm-463	75	24	seconds	second	NOUN
ajlm-463	75	25	,	,	PUNCT
ajlm-463	75	26	50	50	NUM
ajlm-463	75	27	°	°	NOUN
ajlm-463	75	28	c	c	NOUN
ajlm-463	75	29	for	for	ADP
ajlm-463	75	30	five	five	NUM
ajlm-463	75	31	seconds	second	NOUN
ajlm-463	75	32	,	,	PUNCT
ajlm-463	75	33	60	60	NUM
ajlm-463	75	34	°	°	NUM
ajlm-463	75	35	c	c	NOUN
ajlm-463	75	36	for	for	ADP
ajlm-463	75	37	four	four	NUM
ajlm-463	75	38	minutes	minute	NOUN
ajlm-463	75	39	;	;	PUNCT
ajlm-463	75	40	followed	follow	VERB
ajlm-463	75	41	by	by	ADP
ajlm-463	75	42	a	a	DET
ajlm-463	75	43	10	10	NUM
ajlm-463	75	44	-	-	PUNCT
ajlm-463	75	45	minute	minute	NOUN
ajlm-463	75	46	final	final	ADJ
ajlm-463	75	47	extension	extension	NOUN
ajlm-463	75	48	at	at	ADP
ajlm-463	75	49	72	72	NUM
ajlm-463	75	50	°	°	NOUN
ajlm-463	75	51	c	c	NOUN
ajlm-463	75	52	.	.	PUNCT
ajlm-463	76	1	the	the	DET
ajlm-463	76	2	completed	complete	VERB
ajlm-463	76	3	sequencing	sequence	VERB
ajlm-463	76	4	reaction	reaction	NOUN
ajlm-463	76	5	mixture	mixture	NOUN
ajlm-463	76	6	was	be	AUX
ajlm-463	76	7	purified	purify	VERB
ajlm-463	76	8	using	use	VERB
ajlm-463	76	9	75	75	NUM
ajlm-463	76	10	%	%	NOUN
ajlm-463	76	11	isopropanol	isopropanol	NOUN
ajlm-463	76	12	as	as	ADP
ajlm-463	76	13	per	per	ADP
ajlm-463	76	14	the	the	DET
ajlm-463	76	15	manufacturer	manufacturer	NOUN
ajlm-463	76	16	’s	’s	PART
ajlm-463	76	17	instructions	instruction	NOUN
ajlm-463	76	18	.	.	PUNCT
ajlm-463	77	1	the	the	DET
ajlm-463	77	2	sample	sample	NOUN
ajlm-463	77	3	plate	plate	NOUN
ajlm-463	77	4	was	be	AUX
ajlm-463	77	5	loaded	load	VERB
ajlm-463	77	6	onto	onto	ADP
ajlm-463	77	7	the	the	DET
ajlm-463	77	8	abi	abi	PROPN
ajlm-463	77	9	3700	3700	NUM
ajlm-463	77	10	automated	automate	VERB
ajlm-463	77	11	dna	dna	PROPN
ajlm-463	77	12	sequencer	sequencer	NOUN
ajlm-463	77	13	and	and	CCONJ
ajlm-463	77	14	the	the	DET
ajlm-463	77	15	resulting	result	VERB
ajlm-463	77	16	sequences	sequence	NOUN
ajlm-463	77	17	were	be	AUX
ajlm-463	77	18	analysed	analyse	VERB
ajlm-463	77	19	and	and	CCONJ
ajlm-463	77	20	compared	compare	VERB
ajlm-463	77	21	to	to	ADP
ajlm-463	77	22	the	the	DET
ajlm-463	77	23	wild	wild	ADJ
ajlm-463	77	24	-	-	PUNCT
ajlm-463	77	25	type	type	NOUN
ajlm-463	77	26	sequence	sequence	NOUN
ajlm-463	77	27	of	of	ADP
ajlm-463	77	28	the	the	DET
ajlm-463	77	29	well	well	ADV
ajlm-463	77	30	-	-	PUNCT
ajlm-463	77	31	characterised	characterise	VERB
ajlm-463	77	32	m.	m.	NOUN
ajlm-463	77	33	tuberculosis	tuberculosis	NOUN
ajlm-463	77	34	h37rv	h37rv	PROPN
ajlm-463	77	35	reference	reference	NOUN
ajlm-463	77	36	strain	strain	NOUN
ajlm-463	77	37	using	use	VERB
ajlm-463	77	38	sequencher	sequencher	ADJ
ajlm-463	77	39	software	software	NOUN
ajlm-463	77	40	v4.8	v4.8	PROPN
ajlm-463	77	41	(	(	PUNCT
ajlm-463	77	42	genecodes	genecode	NOUN
ajlm-463	77	43	corporation	corporation	NOUN
ajlm-463	77	44	,	,	PUNCT
ajlm-463	77	45	ann	ann	PROPN
ajlm-463	77	46	arbor	arbor	PROPN
ajlm-463	77	47	,	,	PUNCT
ajlm-463	77	48	michigan	michigan	PROPN
ajlm-463	77	49	,	,	PUNCT
ajlm-463	77	50	united	united	PROPN
ajlm-463	77	51	states	states	PROPN
ajlm-463	77	52	)	)	PUNCT
ajlm-463	77	53	.	.	PUNCT
ajlm-463	78	1	the	the	DET
ajlm-463	78	2	well	well	ADV
ajlm-463	78	3	-	-	PUNCT
ajlm-463	78	4	defined	define	VERB
ajlm-463	78	5	rrdr	rrdr	ADJ
ajlm-463	78	6	region	region	NOUN
ajlm-463	78	7	(	(	PUNCT
ajlm-463	78	8	codons	codon	NOUN
ajlm-463	78	9	507–533	507–533	NUM
ajlm-463	78	10	)	)	PUNCT
ajlm-463	78	11	corresponded	correspond	VERB
ajlm-463	78	12	to	to	ADP
ajlm-463	78	13	codons	codon	NOUN
ajlm-463	78	14	426–452	426–452	NUM
ajlm-463	78	15	(	(	PUNCT
ajlm-463	78	16	nucleotides	nucleotide	NOUN
ajlm-463	78	17	1276–1356	1276–1356	NUM
ajlm-463	78	18	)	)	PUNCT
ajlm-463	78	19	in	in	ADP
ajlm-463	78	20	the	the	DET
ajlm-463	78	21	downloaded	download	VERB
ajlm-463	78	22	h37rv	h37rv	PROPN
ajlm-463	78	23	reference	reference	NOUN
ajlm-463	78	24	sequence	sequence	NOUN
ajlm-463	78	25	.	.	PUNCT
ajlm-463	79	1	statistical	statistical	ADJ
ajlm-463	79	2	analysis	analysis	NOUN
ajlm-463	79	3	all	all	DET
ajlm-463	79	4	study	study	NOUN
ajlm-463	79	5	data	datum	NOUN
ajlm-463	79	6	were	be	AUX
ajlm-463	79	7	entered	enter	VERB
ajlm-463	79	8	into	into	ADP
ajlm-463	79	9	an	an	DET
ajlm-463	79	10	excel	excel	NOUN
ajlm-463	79	11	spreadsheet	spreadsheet	NOUN
ajlm-463	79	12	and	and	CCONJ
ajlm-463	79	13	then	then	ADV
ajlm-463	79	14	exported	export	VERB
ajlm-463	79	15	and	and	CCONJ
ajlm-463	79	16	analysed	analyse	VERB
ajlm-463	79	17	using	use	VERB
ajlm-463	79	18	stata	stata	NOUN
ajlm-463	79	19	version	version	NOUN
ajlm-463	79	20	12	12	NUM
ajlm-463	79	21	(	(	PUNCT
ajlm-463	79	22	statacorp	statacorp	PROPN
ajlm-463	79	23	,	,	PUNCT
ajlm-463	79	24	college	college	NOUN
ajlm-463	79	25	station	station	NOUN
ajlm-463	79	26	,	,	PUNCT
ajlm-463	79	27	texas	texas	PROPN
ajlm-463	79	28	,	,	PUNCT
ajlm-463	79	29	united	united	PROPN
ajlm-463	79	30	states	states	PROPN
ajlm-463	79	31	)	)	PUNCT
ajlm-463	79	32	.	.	PUNCT
ajlm-463	80	1	we	we	PRON
ajlm-463	80	2	calculated	calculate	VERB
ajlm-463	80	3	proportions	proportion	NOUN
ajlm-463	80	4	and	and	CCONJ
ajlm-463	80	5	percentages	percentage	NOUN
ajlm-463	80	6	based	base	VERB
ajlm-463	80	7	on	on	ADP
ajlm-463	80	8	district	district	NOUN
ajlm-463	80	9	,	,	PUNCT
ajlm-463	80	10	patient	patient	ADJ
ajlm-463	80	11	category	category	NOUN
ajlm-463	80	12	,	,	PUNCT
ajlm-463	80	13	xpert	xpert	PROPN
ajlm-463	80	14	mtb	mtb	PROPN
ajlm-463	80	15	/	/	SYM
ajlm-463	80	16	rif	rif	NOUN
ajlm-463	80	17	probes	probe	NOUN
ajlm-463	80	18	and	and	CCONJ
ajlm-463	80	19	codons	codon	NOUN
ajlm-463	80	20	in	in	ADP
ajlm-463	80	21	the	the	DET
ajlm-463	80	22	rrdr	rrdr	NOUN
ajlm-463	80	23	of	of	ADP
ajlm-463	80	24	the	the	DET
ajlm-463	80	25	rpob	rpob	ADJ
ajlm-463	80	26	gene	gene	NOUN
ajlm-463	80	27	to	to	PART
ajlm-463	80	28	determine	determine	VERB
ajlm-463	80	29	resistance	resistance	NOUN
ajlm-463	80	30	mutations	mutation	NOUN
ajlm-463	80	31	and	and	CCONJ
ajlm-463	80	32	their	their	PRON
ajlm-463	80	33	prevalence	prevalence	NOUN
ajlm-463	80	34	.	.	PUNCT
ajlm-463	81	1	results	result	VERB
ajlm-463	81	2	the	the	DET
ajlm-463	81	3	644	644	NUM
ajlm-463	81	4	specimens	specimen	NOUN
ajlm-463	81	5	from	from	ADP
ajlm-463	81	6	ntrl	ntrl	NOUN
ajlm-463	81	7	were	be	AUX
ajlm-463	81	8	categorised	categorise	VERB
ajlm-463	81	9	clinically	clinically	ADV
ajlm-463	81	10	as	as	ADP
ajlm-463	81	11	previously	previously	ADV
ajlm-463	81	12	treated	treat	VERB
ajlm-463	81	13	cases	case	NOUN
ajlm-463	81	14	(	(	PUNCT
ajlm-463	81	15	574/644	574/644	NUM
ajlm-463	81	16	;	;	PUNCT
ajlm-463	81	17	89.1	89.1	NUM
ajlm-463	81	18	%	%	NOUN
ajlm-463	81	19	)	)	PUNCT
ajlm-463	81	20	,	,	PUNCT
ajlm-463	81	21	new	new	ADJ
ajlm-463	81	22	(	(	PUNCT
ajlm-463	81	23	27/644	27/644	NUM
ajlm-463	81	24	;	;	PUNCT
ajlm-463	81	25	4.2	4.2	NUM
ajlm-463	81	26	%	%	NOUN
ajlm-463	81	27	)	)	PUNCT
ajlm-463	81	28	,	,	PUNCT
ajlm-463	81	29	or	or	CCONJ
ajlm-463	81	30	not	not	PART
ajlm-463	81	31	known	know	VERB
ajlm-463	81	32	(	(	PUNCT
ajlm-463	81	33	43/644	43/644	NUM
ajlm-463	81	34	;	;	PUNCT
ajlm-463	81	35	6.7	6.7	NUM
ajlm-463	81	36	%	%	NOUN
ajlm-463	81	37	)	)	PUNCT
ajlm-463	81	38	.	.	PUNCT
ajlm-463	82	1	from	from	ADP
ajlm-463	82	2	bwaila	bwaila	NOUN
ajlm-463	82	3	,	,	PUNCT
ajlm-463	82	4	24/351	24/351	NUM
ajlm-463	82	5	(	(	PUNCT
ajlm-463	82	6	6.8	6.8	NUM
ajlm-463	82	7	%	%	NOUN
ajlm-463	82	8	)	)	PUNCT
ajlm-463	82	9	suspected	suspect	VERB
ajlm-463	82	10	tuberculosis	tuberculosis	NOUN
ajlm-463	82	11	cases	case	NOUN
ajlm-463	82	12	were	be	AUX
ajlm-463	82	13	categorised	categorise	VERB
ajlm-463	82	14	as	as	ADP
ajlm-463	82	15	retreatment	retreatment	NOUN
ajlm-463	82	16	,	,	PUNCT
ajlm-463	82	17	and	and	CCONJ
ajlm-463	82	18	327/351	327/351	NUM
ajlm-463	82	19	(	(	PUNCT
ajlm-463	82	20	93.2	93.2	NUM
ajlm-463	82	21	%	%	NOUN
ajlm-463	82	22	)	)	PUNCT
ajlm-463	82	23	were	be	AUX
ajlm-463	82	24	from	from	ADP
ajlm-463	82	25	patients	patient	NOUN
ajlm-463	82	26	presenting	present	VERB
ajlm-463	82	27	with	with	ADP
ajlm-463	82	28	tuberculosis	tuberculosis	NOUN
ajlm-463	82	29	for	for	ADP
ajlm-463	82	30	the	the	DET
ajlm-463	82	31	first	first	ADJ
ajlm-463	82	32	time	time	NOUN
ajlm-463	82	33	.	.	PUNCT
ajlm-463	83	1	the	the	DET
ajlm-463	83	2	xpert	xpert	PROPN
ajlm-463	83	3	mtb	mtb	PROPN
ajlm-463	83	4	/	/	SYM
ajlm-463	83	5	rif	rif	PROPN
ajlm-463	83	6	assay	assay	PROPN
ajlm-463	83	7	detected	detect	VERB
ajlm-463	83	8	rifampicin	rifampicin	VERB
ajlm-463	83	9	resistance	resistance	NOUN
ajlm-463	83	10	in	in	ADP
ajlm-463	83	11	64/995	64/995	PROPN
ajlm-463	83	12	(	(	PUNCT
ajlm-463	83	13	6.4	6.4	NUM
ajlm-463	83	14	%	%	NOUN
ajlm-463	83	15	)	)	PUNCT
ajlm-463	83	16	specimens	specimen	NOUN
ajlm-463	83	17	,	,	PUNCT
ajlm-463	83	18	which	which	PRON
ajlm-463	83	19	were	be	AUX
ajlm-463	83	20	selected	select	VERB
ajlm-463	83	21	for	for	ADP
ajlm-463	83	22	further	further	ADJ
ajlm-463	83	23	dna	dna	NOUN
ajlm-463	83	24	sequencing	sequencing	NOUN
ajlm-463	83	25	of	of	ADP
ajlm-463	83	26	the	the	DET
ajlm-463	83	27	larger	large	ADJ
ajlm-463	83	28	region	region	NOUN
ajlm-463	83	29	of	of	ADP
ajlm-463	83	30	the	the	DET
ajlm-463	83	31	rpob	rpob	PROPN
ajlm-463	83	32	gene	gene	NOUN
ajlm-463	83	33	.	.	PUNCT
ajlm-463	84	1	three	three	NUM
ajlm-463	84	2	specimens	specimen	NOUN
ajlm-463	84	3	(	(	PUNCT
ajlm-463	84	4	3/64	3/64	NUM
ajlm-463	84	5	)	)	PUNCT
ajlm-463	84	6	were	be	AUX
ajlm-463	84	7	from	from	ADP
ajlm-463	84	8	bwaila	bwaila	NOUN
ajlm-463	84	9	,	,	PUNCT
ajlm-463	84	10	while	while	SCONJ
ajlm-463	84	11	the	the	DET
ajlm-463	84	12	rest	rest	NOUN
ajlm-463	84	13	(	(	PUNCT
ajlm-463	84	14	61/64	61/64	NOUN
ajlm-463	84	15	)	)	PUNCT
ajlm-463	84	16	were	be	AUX
ajlm-463	84	17	collected	collect	VERB
ajlm-463	84	18	from	from	ADP
ajlm-463	84	19	ntrl	ntrl	NOUN
ajlm-463	84	20	.	.	PUNCT
ajlm-463	85	1	most	most	ADJ
ajlm-463	85	2	of	of	ADP
ajlm-463	85	3	the	the	DET
ajlm-463	85	4	rifampicin	rifampicin	VERB
ajlm-463	85	5	-	-	PUNCT
ajlm-463	85	6	resistant	resistant	ADJ
ajlm-463	85	7	cases	case	NOUN
ajlm-463	85	8	detected	detect	VERB
ajlm-463	85	9	by	by	ADP
ajlm-463	85	10	xpert	xpert	PROPN
ajlm-463	85	11	mtb	mtb	PROPN
ajlm-463	85	12	/	/	SYM
ajlm-463	85	13	rif	rif	PROPN
ajlm-463	85	14	were	be	AUX
ajlm-463	85	15	associated	associate	VERB
ajlm-463	85	16	with	with	ADP
ajlm-463	85	17	probe	probe	NOUN
ajlm-463	85	18	b	b	PROPN
ajlm-463	85	19	(	(	PUNCT
ajlm-463	85	20	23/64	23/64	NUM
ajlm-463	85	21	)	)	PUNCT
ajlm-463	85	22	and	and	CCONJ
ajlm-463	85	23	probe	probe	NOUN
ajlm-463	85	24	e	e	X
ajlm-463	85	25	(	(	PUNCT
ajlm-463	85	26	23/64	23/64	NOUN
ajlm-463	85	27	)	)	PUNCT
ajlm-463	85	28	.	.	PUNCT
ajlm-463	86	1	fifteen	fifteen	NUM
ajlm-463	86	2	(	(	PUNCT
ajlm-463	86	3	15/64	15/64	NUM
ajlm-463	86	4	)	)	PUNCT
ajlm-463	86	5	samples	sample	NOUN
ajlm-463	86	6	were	be	AUX
ajlm-463	86	7	detected	detect	VERB
ajlm-463	86	8	by	by	ADP
ajlm-463	86	9	probe	probe	NOUN
ajlm-463	86	10	d	d	PROPN
ajlm-463	86	11	,	,	PUNCT
ajlm-463	86	12	2/64	2/64	NUM
ajlm-463	86	13	by	by	ADP
ajlm-463	86	14	probe	probe	NOUN
ajlm-463	86	15	a	a	X
ajlm-463	86	16	,	,	PUNCT
ajlm-463	86	17	while	while	SCONJ
ajlm-463	86	18	probe	probe	NOUN
ajlm-463	86	19	c	c	NOUN
ajlm-463	86	20	detected	detect	VERB
ajlm-463	86	21	1/64	1/64	NUM
ajlm-463	86	22	samples	sample	NOUN
ajlm-463	86	23	(	(	PUNCT
ajlm-463	86	24	table	table	NOUN
ajlm-463	86	25	1	1	NUM
ajlm-463	86	26	)	)	PUNCT
ajlm-463	86	27	.	.	PUNCT
ajlm-463	87	1	of	of	ADP
ajlm-463	87	2	these	these	PRON
ajlm-463	87	3	,	,	PUNCT
ajlm-463	87	4	43/64	43/64	NUM
ajlm-463	87	5	were	be	AUX
ajlm-463	87	6	successfully	successfully	ADV
ajlm-463	87	7	sequenced	sequence	VERB
ajlm-463	87	8	.	.	PUNCT
ajlm-463	88	1	the	the	DET
ajlm-463	88	2	remainder	remainder	NOUN
ajlm-463	88	3	(	(	PUNCT
ajlm-463	88	4	n=	n=	ADJ
ajlm-463	88	5	21	21	NUM
ajlm-463	88	6	;	;	PUNCT
ajlm-463	88	7	32.8	32.8	NUM
ajlm-463	88	8	%	%	NOUN
ajlm-463	88	9	)	)	PUNCT
ajlm-463	88	10	,	,	PUNCT
ajlm-463	88	11	all	all	ADV
ajlm-463	88	12	from	from	ADP
ajlm-463	88	13	ntrl	ntrl	NOUN
ajlm-463	88	14	,	,	PUNCT
ajlm-463	88	15	were	be	AUX
ajlm-463	88	16	not	not	PART
ajlm-463	88	17	sequenced	sequence	VERB
ajlm-463	88	18	,	,	PUNCT
ajlm-463	88	19	either	either	CCONJ
ajlm-463	88	20	due	due	ADJ
ajlm-463	88	21	to	to	ADP
ajlm-463	88	22	failure	failure	NOUN
ajlm-463	88	23	of	of	ADP
ajlm-463	88	24	pcr	pcr	ADJ
ajlm-463	88	25	amplification	amplification	NOUN
ajlm-463	88	26	(	(	PUNCT
ajlm-463	88	27	n	n	NOUN
ajlm-463	88	28	=	=	SYM
ajlm-463	88	29	19	19	NUM
ajlm-463	88	30	)	)	PUNCT
ajlm-463	88	31	or	or	CCONJ
ajlm-463	88	32	they	they	PRON
ajlm-463	88	33	failed	fail	VERB
ajlm-463	88	34	sequencing	sequence	VERB
ajlm-463	88	35	(	(	PUNCT
ajlm-463	88	36	n	n	NOUN
ajlm-463	88	37	=	=	SYM
ajlm-463	88	38	2	2	NUM
ajlm-463	88	39	)	)	PUNCT
ajlm-463	88	40	(	(	PUNCT
ajlm-463	88	41	figure	figure	NOUN
ajlm-463	88	42	1	1	NUM
ajlm-463	88	43	)	)	PUNCT
ajlm-463	88	44	.	.	PUNCT
ajlm-463	89	1	the	the	DET
ajlm-463	89	2	pcr	pcr	ADJ
ajlm-463	89	3	amplification	amplification	NOUN
ajlm-463	89	4	failure	failure	NOUN
ajlm-463	89	5	could	could	AUX
ajlm-463	89	6	not	not	PART
ajlm-463	89	7	be	be	AUX
ajlm-463	89	8	explained	explain	VERB
ajlm-463	89	9	,	,	PUNCT
ajlm-463	89	10	although	although	SCONJ
ajlm-463	89	11	in	in	ADP
ajlm-463	89	12	part	part	NOUN
ajlm-463	89	13	this	this	PRON
ajlm-463	89	14	could	could	AUX
ajlm-463	89	15	be	be	AUX
ajlm-463	89	16	due	due	ADJ
ajlm-463	89	17	to	to	ADP
ajlm-463	89	18	insufficient	insufficient	ADJ
ajlm-463	89	19	template	template	NOUN
ajlm-463	89	20	dna	dna	NOUN
ajlm-463	89	21	,	,	PUNCT
ajlm-463	89	22	a	a	DET
ajlm-463	89	23	an	an	DET
ajlm-463	89	24	attempt	attempt	NOUN
ajlm-463	89	25	was	be	AUX
ajlm-463	89	26	made	make	VERB
ajlm-463	89	27	to	to	PART
ajlm-463	89	28	extract	extract	VERB
ajlm-463	89	29	dna	dna	NOUN
ajlm-463	89	30	from	from	ADP
ajlm-463	89	31	pellets	pellet	NOUN
ajlm-463	89	32	(	(	PUNCT
ajlm-463	89	33	n	n	NOUN
ajlm-463	89	34	=	=	SYM
ajlm-463	89	35	7	7	NUM
ajlm-463	89	36	)	)	PUNCT
ajlm-463	89	37	which	which	PRON
ajlm-463	89	38	had	have	AUX
ajlm-463	89	39	not	not	PART
ajlm-463	89	40	grown	grow	VERB
ajlm-463	89	41	on	on	ADP
ajlm-463	89	42	culture	culture	NOUN
ajlm-463	89	43	.	.	PUNCT
ajlm-463	90	1	figure	figure	VERB
ajlm-463	90	2	1	1	NUM
ajlm-463	90	3	:	:	PUNCT
ajlm-463	90	4	workflow	workflow	NOUN
ajlm-463	90	5	and	and	CCONJ
ajlm-463	90	6	isolate	isolate	VERB
ajlm-463	90	7	selection	selection	NOUN
ajlm-463	90	8	for	for	ADP
ajlm-463	90	9	dna	dna	NOUN
ajlm-463	90	10	sequencing	sequence	VERB
ajlm-463	90	11	from	from	ADP
ajlm-463	90	12	tuberculosis	tuberculosis	NOUN
ajlm-463	90	13	cultures	culture	NOUN
ajlm-463	90	14	and	and	CCONJ
ajlm-463	90	15	processed	process	VERB
ajlm-463	90	16	sediments	sediment	NOUN
ajlm-463	90	17	.	.	PUNCT
ajlm-463	91	1	table	table	NOUN
ajlm-463	91	2	1	1	NUM
ajlm-463	91	3	:	:	PUNCT
ajlm-463	91	4	 	 	SPACE
ajlm-463	91	5	rpob	rpob	ADJ
ajlm-463	91	6	gene	gene	NOUN
ajlm-463	91	7	mutations	mutation	NOUN
ajlm-463	91	8	associated	associate	VERB
ajlm-463	91	9	with	with	ADP
ajlm-463	91	10	xpert	xpert	PROPN
ajlm-463	91	11	mtb	mtb	PROPN
ajlm-463	91	12	/	/	SYM
ajlm-463	91	13	rif	rif	NOUN
ajlm-463	91	14	probes	probe	NOUN
ajlm-463	91	15	used	use	VERB
ajlm-463	91	16	.	.	PUNCT
ajlm-463	92	1	seven	seven	NUM
ajlm-463	92	2	different	different	ADJ
ajlm-463	92	3	mutations	mutation	NOUN
ajlm-463	92	4	were	be	AUX
ajlm-463	92	5	detected	detect	VERB
ajlm-463	92	6	in	in	ADP
ajlm-463	92	7	37/43	37/43	NUM
ajlm-463	92	8	(	(	PUNCT
ajlm-463	92	9	86	86	NUM
ajlm-463	92	10	%	%	NOUN
ajlm-463	92	11	)	)	PUNCT
ajlm-463	92	12	specimens	specimen	NOUN
ajlm-463	92	13	in	in	ADP
ajlm-463	92	14	codons	codon	NOUN
ajlm-463	92	15	511	511	NUM
ajlm-463	92	16	,	,	PUNCT
ajlm-463	92	17	512	512	NUM
ajlm-463	92	18	,	,	PUNCT
ajlm-463	92	19	513	513	NUM
ajlm-463	92	20	,	,	PUNCT
ajlm-463	92	21	516	516	NUM
ajlm-463	92	22	,	,	PUNCT
ajlm-463	92	23	522	522	NUM
ajlm-463	92	24	,	,	PUNCT
ajlm-463	92	25	526	526	NUM
ajlm-463	92	26	and	and	CCONJ
ajlm-463	92	27	531	531	NUM
ajlm-463	92	28	.	.	PUNCT
ajlm-463	93	1	mutations	mutation	NOUN
ajlm-463	93	2	were	be	AUX
ajlm-463	93	3	common	common	ADJ
ajlm-463	93	4	in	in	ADP
ajlm-463	93	5	codons	codon	NOUN
ajlm-463	93	6	526	526	NUM
ajlm-463	93	7	(	(	PUNCT
ajlm-463	93	8	38	38	NUM
ajlm-463	93	9	%	%	NOUN
ajlm-463	93	10	)	)	PUNCT
ajlm-463	93	11	,	,	PUNCT
ajlm-463	93	12	531	531	NUM
ajlm-463	93	13	(	(	PUNCT
ajlm-463	93	14	29.7	29.7	NUM
ajlm-463	93	15	%	%	NOUN
ajlm-463	93	16	)	)	PUNCT
ajlm-463	93	17	and	and	CCONJ
ajlm-463	93	18	516	516	NUM
ajlm-463	93	19	(	(	PUNCT
ajlm-463	93	20	16.2	16.2	NUM
ajlm-463	93	21	%	%	NOUN
ajlm-463	93	22	)	)	PUNCT
ajlm-463	93	23	(	(	PUNCT
ajlm-463	93	24	table	table	NOUN
ajlm-463	93	25	2	2	NUM
ajlm-463	93	26	)	)	PUNCT
ajlm-463	93	27	.	.	PUNCT
ajlm-463	94	1	no	no	DET
ajlm-463	94	2	insertion	insertion	NOUN
ajlm-463	94	3	,	,	PUNCT
ajlm-463	94	4	deletion	deletion	NOUN
ajlm-463	94	5	or	or	CCONJ
ajlm-463	94	6	double	double	ADJ
ajlm-463	94	7	point	point	NOUN
ajlm-463	94	8	mutations	mutation	NOUN
ajlm-463	94	9	were	be	AUX
ajlm-463	94	10	observed	observe	VERB
ajlm-463	94	11	.	.	PUNCT
ajlm-463	95	1	however	however	ADV
ajlm-463	95	2	,	,	PUNCT
ajlm-463	95	3	mutations	mutation	NOUN
ajlm-463	95	4	were	be	AUX
ajlm-463	95	5	not	not	PART
ajlm-463	95	6	detected	detect	VERB
ajlm-463	95	7	in	in	ADP
ajlm-463	95	8	6/43	6/43	NUM
ajlm-463	95	9	(	(	PUNCT
ajlm-463	95	10	14	14	NUM
ajlm-463	95	11	%	%	NOUN
ajlm-463	95	12	)	)	PUNCT
ajlm-463	95	13	of	of	ADP
ajlm-463	95	14	the	the	DET
ajlm-463	95	15	strains	strain	NOUN
ajlm-463	95	16	by	by	ADP
ajlm-463	95	17	dna	dna	NOUN
ajlm-463	95	18	sequencing	sequencing	NOUN
ajlm-463	95	19	,	,	PUNCT
ajlm-463	95	20	despite	despite	SCONJ
ajlm-463	95	21	being	be	AUX
ajlm-463	95	22	detected	detect	VERB
ajlm-463	95	23	by	by	ADP
ajlm-463	95	24	xpert	xpert	PROPN
ajlm-463	95	25	mtb	mtb	PROPN
ajlm-463	95	26	/	/	SYM
ajlm-463	95	27	rif	rif	PROPN
ajlm-463	95	28	probe	probe	PROPN
ajlm-463	95	29	b	b	PROPN
ajlm-463	95	30	(	(	PUNCT
ajlm-463	95	31	4/6	4/6	NUM
ajlm-463	95	32	)	)	PUNCT
ajlm-463	95	33	and	and	CCONJ
ajlm-463	95	34	by	by	ADP
ajlm-463	95	35	probe	probe	NOUN
ajlm-463	95	36	e	e	X
ajlm-463	95	37	(	(	PUNCT
ajlm-463	95	38	2/6	2/6	NUM
ajlm-463	95	39	)	)	PUNCT
ajlm-463	95	40	as	as	SCONJ
ajlm-463	95	41	rifampicin	rifampicin	VERB
ajlm-463	95	42	resistant	resistant	ADJ
ajlm-463	95	43	.	.	PUNCT
ajlm-463	96	1	repeat	repeat	VERB
ajlm-463	96	2	xpert	xpert	PROPN
ajlm-463	96	3	mtb	mtb	PROPN
ajlm-463	96	4	/	/	SYM
ajlm-463	96	5	rif	rif	PROPN
ajlm-463	96	6	testing	testing	NOUN
ajlm-463	96	7	was	be	AUX
ajlm-463	96	8	not	not	PART
ajlm-463	96	9	done	do	VERB
ajlm-463	96	10	for	for	ADP
ajlm-463	96	11	these	these	DET
ajlm-463	96	12	strains	strain	NOUN
ajlm-463	96	13	due	due	ADJ
ajlm-463	96	14	to	to	ADP
ajlm-463	96	15	insufficient	insufficient	ADJ
ajlm-463	96	16	left	leave	VERB
ajlm-463	96	17	-	-	PUNCT
ajlm-463	96	18	over	over	ADP
ajlm-463	96	19	pellets	pellet	NOUN
ajlm-463	96	20	.	.	PUNCT
ajlm-463	97	1	delayed	delay	VERB
ajlm-463	97	2	ct	ct	NUM
ajlm-463	97	3	values	value	NOUN
ajlm-463	97	4	between	between	ADP
ajlm-463	97	5	17.0	17.0	NUM
ajlm-463	97	6	and	and	CCONJ
ajlm-463	97	7	32.7	32.7	NUM
ajlm-463	97	8	were	be	AUX
ajlm-463	97	9	observed	observe	VERB
ajlm-463	97	10	in	in	ADP
ajlm-463	97	11	4/6	4/6	NUM
ajlm-463	97	12	strains	strain	NOUN
ajlm-463	97	13	which	which	PRON
ajlm-463	97	14	had	have	VERB
ajlm-463	97	15	no	no	DET
ajlm-463	97	16	mutations	mutation	NOUN
ajlm-463	97	17	.	.	PUNCT
ajlm-463	98	1	the	the	DET
ajlm-463	98	2	observed	observe	VERB
ajlm-463	98	3	ct	ct	NOUN
ajlm-463	98	4	values	value	NOUN
ajlm-463	98	5	were	be	AUX
ajlm-463	98	6	markedly	markedly	ADV
ajlm-463	98	7	higher	high	ADJ
ajlm-463	98	8	than	than	ADP
ajlm-463	98	9	the	the	DET
ajlm-463	98	10	δct	δct	NOUN
ajlm-463	98	11	max	max	PROPN
ajlm-463	98	12	cutoff	cutoff	NOUN
ajlm-463	98	13	of	of	ADP
ajlm-463	98	14	>	>	X
ajlm-463	98	15	4	4	NUM
ajlm-463	98	16	for	for	ADP
ajlm-463	98	17	the	the	DET
ajlm-463	98	18	automated	automate	VERB
ajlm-463	98	19	detection	detection	NOUN
ajlm-463	98	20	of	of	ADP
ajlm-463	98	21	rifampicin	rifampicin	VERB
ajlm-463	98	22	resistance	resistance	NOUN
ajlm-463	98	23	by	by	ADP
ajlm-463	98	24	the	the	DET
ajlm-463	98	25	xpert	xpert	PROPN
ajlm-463	98	26	mtb	mtb	PROPN
ajlm-463	98	27	/	/	SYM
ajlm-463	98	28	rif	rif	PROPN
ajlm-463	98	29	assay.25	assay.25	PROPN
ajlm-463	98	30	the	the	DET
ajlm-463	98	31	remainder	remainder	NOUN
ajlm-463	98	32	(	(	PUNCT
ajlm-463	98	33	n	n	NOUN
ajlm-463	98	34	=	=	SYM
ajlm-463	98	35	2	2	NUM
ajlm-463	98	36	)	)	PUNCT
ajlm-463	98	37	gave	give	VERB
ajlm-463	98	38	an	an	DET
ajlm-463	98	39	undetectable	undetectable	ADJ
ajlm-463	98	40	result	result	NOUN
ajlm-463	98	41	on	on	ADP
ajlm-463	98	42	probe	probe	PROPN
ajlm-463	98	43	b	b	PROPN
ajlm-463	98	44	(	(	PUNCT
ajlm-463	98	45	n	n	NOUN
ajlm-463	98	46	=	=	SYM
ajlm-463	98	47	1	1	NUM
ajlm-463	98	48	)	)	PUNCT
ajlm-463	98	49	and	and	CCONJ
ajlm-463	98	50	probe	probe	NOUN
ajlm-463	98	51	e	e	X
ajlm-463	98	52	(	(	PUNCT
ajlm-463	98	53	n	n	NOUN
ajlm-463	98	54	=	=	SYM
ajlm-463	98	55	1	1	NUM
ajlm-463	98	56	)	)	PUNCT
ajlm-463	98	57	.	.	PUNCT
ajlm-463	99	1	table	table	NOUN
ajlm-463	99	2	2	2	NUM
ajlm-463	99	3	:	:	PUNCT
ajlm-463	99	4	 	 	SPACE
ajlm-463	99	5	distribution	distribution	NOUN
ajlm-463	99	6	of	of	ADP
ajlm-463	99	7	mutations	mutation	NOUN
ajlm-463	99	8	in	in	ADP
ajlm-463	99	9	codons	codon	NOUN
ajlm-463	99	10	491–574	491–574	NUM
ajlm-463	99	11	of	of	ADP
ajlm-463	99	12	the	the	DET
ajlm-463	99	13	rpob	rpob	ADJ
ajlm-463	99	14	gene	gene	NOUN
ajlm-463	99	15	and	and	CCONJ
ajlm-463	99	16	amino	amino	NOUN
ajlm-463	99	17	acid	acid	NOUN
ajlm-463	99	18	changes	change	NOUN
ajlm-463	99	19	in	in	ADP
ajlm-463	99	20	the	the	DET
ajlm-463	99	21	rifampicin	rifampicin	VERB
ajlm-463	99	22	resistance	resistance	NOUN
ajlm-463	99	23	determining	determine	VERB
ajlm-463	99	24	region	region	NOUN
ajlm-463	99	25	,	,	PUNCT
ajlm-463	99	26	malawi	malawi	PROPN
ajlm-463	99	27	,	,	PUNCT
ajlm-463	99	28	2011	2011	NUM
ajlm-463	99	29	and	and	CCONJ
ajlm-463	99	30	2014†.	2014†.	NUM
ajlm-463	99	31	when	when	SCONJ
ajlm-463	99	32	stratified	stratify	VERB
ajlm-463	99	33	by	by	ADP
ajlm-463	99	34	district	district	NOUN
ajlm-463	99	35	,	,	PUNCT
ajlm-463	99	36	the	the	DET
ajlm-463	99	37	prevalence	prevalence	NOUN
ajlm-463	99	38	of	of	ADP
ajlm-463	99	39	mutations	mutation	NOUN
ajlm-463	99	40	was	be	AUX
ajlm-463	99	41	high	high	ADJ
ajlm-463	99	42	in	in	ADP
ajlm-463	99	43	tuberculosis	tuberculosis	NOUN
ajlm-463	99	44	patients	patient	NOUN
ajlm-463	99	45	from	from	ADP
ajlm-463	99	46	ntchisi	ntchisi	PROPN
ajlm-463	99	47	2/5	2/5	NUM
ajlm-463	99	48	(	(	PUNCT
ajlm-463	99	49	40	40	NUM
ajlm-463	99	50	%	%	NOUN
ajlm-463	99	51	)	)	PUNCT
ajlm-463	99	52	,	,	PUNCT
ajlm-463	99	53	nkhotakota	nkhotakota	PROPN
ajlm-463	99	54	4/13	4/13	NUM
ajlm-463	99	55	(	(	PUNCT
ajlm-463	99	56	30.8	30.8	NUM
ajlm-463	99	57	%	%	NOUN
ajlm-463	99	58	)	)	PUNCT
ajlm-463	99	59	,	,	PUNCT
ajlm-463	99	60	nsanje	nsanje	NOUN
ajlm-463	99	61	5/20	5/20	NUM
ajlm-463	99	62	(	(	PUNCT
ajlm-463	99	63	25	25	NUM
ajlm-463	99	64	%	%	NOUN
ajlm-463	99	65	)	)	PUNCT
ajlm-463	99	66	and	and	CCONJ
ajlm-463	99	67	balaka	balaka	NOUN
ajlm-463	99	68	2/12	2/12	NUM
ajlm-463	99	69	(	(	PUNCT
ajlm-463	99	70	16.7	16.7	NUM
ajlm-463	99	71	%	%	NOUN
ajlm-463	99	72	)	)	PUNCT
ajlm-463	99	73	.	.	PUNCT
ajlm-463	100	1	lilongwe	lilongwe	PROPN
ajlm-463	100	2	,	,	PUNCT
ajlm-463	100	3	the	the	DET
ajlm-463	100	4	capital	capital	NOUN
ajlm-463	100	5	city	city	NOUN
ajlm-463	100	6	of	of	ADP
ajlm-463	100	7	malawi	malawi	PROPN
ajlm-463	100	8	,	,	PUNCT
ajlm-463	100	9	had	have	VERB
ajlm-463	100	10	the	the	DET
ajlm-463	100	11	lowest	low	ADJ
ajlm-463	100	12	prevalence	prevalence	NOUN
ajlm-463	100	13	of	of	ADP
ajlm-463	100	14	mutations	mutation	NOUN
ajlm-463	100	15	9/466	9/466	NUM
ajlm-463	100	16	(	(	PUNCT
ajlm-463	100	17	1.9	1.9	NUM
ajlm-463	100	18	%	%	NOUN
ajlm-463	100	19	)	)	PUNCT
ajlm-463	100	20	,	,	PUNCT
ajlm-463	100	21	followed	follow	VERB
ajlm-463	100	22	by	by	ADP
ajlm-463	100	23	mulanje	mulanje	NOUN
ajlm-463	100	24	2/57	2/57	NUM
ajlm-463	100	25	(	(	PUNCT
ajlm-463	100	26	3.5	3.5	NUM
ajlm-463	100	27	%	%	NOUN
ajlm-463	100	28	)	)	PUNCT
ajlm-463	100	29	.	.	PUNCT
ajlm-463	101	1	as	as	SCONJ
ajlm-463	101	2	expected	expect	VERB
ajlm-463	101	3	,	,	PUNCT
ajlm-463	101	4	the	the	DET
ajlm-463	101	5	number	number	NOUN
ajlm-463	101	6	of	of	ADP
ajlm-463	101	7	mutations	mutation	NOUN
ajlm-463	101	8	was	be	AUX
ajlm-463	101	9	highest	high	ADJ
ajlm-463	101	10	among	among	ADP
ajlm-463	101	11	patients	patient	NOUN
ajlm-463	101	12	registered	register	VERB
ajlm-463	101	13	as	as	ADP
ajlm-463	101	14	retreatment	retreatment	ADJ
ajlm-463	101	15	29/598	29/598	NUM
ajlm-463	101	16	(	(	PUNCT
ajlm-463	101	17	4.8	4.8	NUM
ajlm-463	101	18	%	%	NOUN
ajlm-463	101	19	)	)	PUNCT
ajlm-463	101	20	,	,	PUNCT
ajlm-463	101	21	compared	compare	VERB
ajlm-463	101	22	with	with	ADP
ajlm-463	101	23	new	new	ADJ
ajlm-463	101	24	cases	case	NOUN
ajlm-463	101	25	8/354	8/354	NUM
ajlm-463	101	26	(	(	PUNCT
ajlm-463	101	27	2.3	2.3	NUM
ajlm-463	101	28	%	%	NOUN
ajlm-463	101	29	)	)	PUNCT
ajlm-463	101	30	.	.	PUNCT
ajlm-463	102	1	there	there	PRON
ajlm-463	102	2	were	be	VERB
ajlm-463	102	3	no	no	DET
ajlm-463	102	4	real	real	ADJ
ajlm-463	102	5	trends	trend	NOUN
ajlm-463	102	6	of	of	ADP
ajlm-463	102	7	mutations	mutation	NOUN
ajlm-463	102	8	across	across	ADP
ajlm-463	102	9	classified	classified	ADJ
ajlm-463	102	10	retreatment	retreatment	ADJ
ajlm-463	102	11	cases	case	NOUN
ajlm-463	102	12	(	(	PUNCT
ajlm-463	102	13	recurrent	recurrent	ADJ
ajlm-463	102	14	,	,	PUNCT
ajlm-463	102	15	default	default	NOUN
ajlm-463	102	16	,	,	PUNCT
ajlm-463	102	17	etc	etc	X
ajlm-463	102	18	.	.	X
ajlm-463	102	19	)	)	PUNCT
ajlm-463	103	1	in	in	ADP
ajlm-463	103	2	relation	relation	NOUN
ajlm-463	103	3	to	to	ADP
ajlm-463	103	4	new	new	ADJ
ajlm-463	103	5	tuberculosis	tuberculosis	NOUN
ajlm-463	103	6	cases	case	NOUN
ajlm-463	103	7	.	.	PUNCT
ajlm-463	104	1	mutations	mutation	NOUN
ajlm-463	104	2	in	in	ADP
ajlm-463	104	3	codon	codon	NOUN
ajlm-463	104	4	531	531	NUM
ajlm-463	104	5	were	be	AUX
ajlm-463	104	6	found	find	VERB
ajlm-463	104	7	in	in	ADP
ajlm-463	104	8	almost	almost	ADV
ajlm-463	104	9	all	all	PRON
ajlm-463	104	10	patient	patient	ADJ
ajlm-463	104	11	groups	group	NOUN
ajlm-463	104	12	,	,	PUNCT
ajlm-463	104	13	except	except	SCONJ
ajlm-463	104	14	for	for	ADP
ajlm-463	104	15	those	those	PRON
ajlm-463	104	16	classified	classify	VERB
ajlm-463	104	17	as	as	ADP
ajlm-463	104	18	recurrent	recurrent	ADJ
ajlm-463	104	19	;	;	PUNCT
ajlm-463	104	20	codon	codon	NOUN
ajlm-463	104	21	526	526	NUM
ajlm-463	104	22	in	in	ADP
ajlm-463	104	23	all	all	DET
ajlm-463	104	24	groups	group	NOUN
ajlm-463	104	25	,	,	PUNCT
ajlm-463	104	26	except	except	SCONJ
ajlm-463	104	27	in	in	ADP
ajlm-463	104	28	the	the	DET
ajlm-463	104	29	‘	'	PUNCT
ajlm-463	104	30	new	new	ADJ
ajlm-463	104	31	patient	patient	NOUN
ajlm-463	104	32	’	'	PUNCT
ajlm-463	104	33	category	category	NOUN
ajlm-463	104	34	in	in	ADP
ajlm-463	104	35	which	which	PRON
ajlm-463	104	36	mutations	mutation	NOUN
ajlm-463	104	37	at	at	ADP
ajlm-463	104	38	codon	codon	NOUN
ajlm-463	104	39	516	516	NUM
ajlm-463	104	40	were	be	AUX
ajlm-463	104	41	predominant	predominant	ADJ
ajlm-463	104	42	.	.	PUNCT
ajlm-463	105	1	a	a	DET
ajlm-463	105	2	single	single	ADJ
ajlm-463	105	3	strain	strain	NOUN
ajlm-463	105	4	from	from	ADP
ajlm-463	105	5	a	a	DET
ajlm-463	105	6	patient	patient	NOUN
ajlm-463	105	7	with	with	ADP
ajlm-463	105	8	no	no	DET
ajlm-463	105	9	history	history	NOUN
ajlm-463	105	10	of	of	ADP
ajlm-463	105	11	prior	prior	ADJ
ajlm-463	105	12	tuberculosis	tuberculosis	PRON
ajlm-463	105	13	treatment	treatment	NOUN
ajlm-463	105	14	was	be	AUX
ajlm-463	105	15	detected	detect	VERB
ajlm-463	105	16	with	with	ADP
ajlm-463	105	17	a	a	DET
ajlm-463	105	18	mutation	mutation	NOUN
ajlm-463	105	19	at	at	ADP
ajlm-463	105	20	codon	codon	PROPN
ajlm-463	105	21	522	522	NUM
ajlm-463	105	22	.	.	PUNCT
ajlm-463	106	1	all	all	DET
ajlm-463	106	2	43	43	NUM
ajlm-463	106	3	specimens	specimen	NOUN
ajlm-463	106	4	that	that	PRON
ajlm-463	106	5	were	be	AUX
ajlm-463	106	6	successfully	successfully	ADV
ajlm-463	106	7	sequenced	sequence	VERB
ajlm-463	106	8	were	be	AUX
ajlm-463	106	9	also	also	ADV
ajlm-463	106	10	tested	test	VERB
ajlm-463	106	11	on	on	ADP
ajlm-463	106	12	genotype	genotype	NOUN
ajlm-463	106	13	mtbdrplus	mtbdrplus	ADJ
ajlm-463	106	14	and	and	CCONJ
ajlm-463	106	15	two	two	NUM
ajlm-463	106	16	strains	strain	NOUN
ajlm-463	106	17	gave	give	VERB
ajlm-463	106	18	discordant	discordant	ADJ
ajlm-463	106	19	results	result	NOUN
ajlm-463	106	20	.	.	PUNCT
ajlm-463	107	1	both	both	DET
ajlm-463	107	2	strains	strain	NOUN
ajlm-463	107	3	showed	show	VERB
ajlm-463	107	4	susceptibility	susceptibility	NOUN
ajlm-463	107	5	to	to	PART
ajlm-463	107	6	rifampicin	rifampicin	VERB
ajlm-463	107	7	on	on	ADP
ajlm-463	107	8	genotype	genotype	NOUN
ajlm-463	107	9	mtbdrplus	mtbdrplus	ADJ
ajlm-463	107	10	,	,	PUNCT
ajlm-463	107	11	but	but	CCONJ
ajlm-463	107	12	resistance	resistance	NOUN
ajlm-463	107	13	to	to	ADP
ajlm-463	107	14	rifampicin	rifampicin	VERB
ajlm-463	107	15	on	on	ADP
ajlm-463	107	16	xpert	xpert	PROPN
ajlm-463	107	17	mtb	mtb	PROPN
ajlm-463	107	18	/	/	SYM
ajlm-463	107	19	rif	rif	PROPN
ajlm-463	107	20	.	.	PUNCT
ajlm-463	108	1	mutations	mutation	NOUN
ajlm-463	108	2	were	be	AUX
ajlm-463	108	3	not	not	PART
ajlm-463	108	4	detected	detect	VERB
ajlm-463	108	5	in	in	ADP
ajlm-463	108	6	these	these	DET
ajlm-463	108	7	strains	strain	NOUN
ajlm-463	108	8	by	by	ADP
ajlm-463	108	9	dna	dna	NOUN
ajlm-463	108	10	sequencing	sequencing	NOUN
ajlm-463	108	11	.	.	PUNCT
ajlm-463	109	1	discussion	discussion	NOUN
ajlm-463	109	2	this	this	DET
ajlm-463	109	3	study	study	NOUN
ajlm-463	109	4	is	be	AUX
ajlm-463	109	5	the	the	DET
ajlm-463	109	6	first	first	ADJ
ajlm-463	109	7	to	to	PART
ajlm-463	109	8	characterise	characterise	VERB
ajlm-463	109	9	rifampicin	rifampicin	VERB
ajlm-463	109	10	resistance	resistance	NOUN
ajlm-463	109	11	in	in	ADP
ajlm-463	109	12	malawi	malawi	PROPN
ajlm-463	109	13	.	.	PUNCT
ajlm-463	110	1	the	the	DET
ajlm-463	110	2	majority	majority	NOUN
ajlm-463	110	3	of	of	ADP
ajlm-463	110	4	rpob	rpob	ADJ
ajlm-463	110	5	gene	gene	NOUN
ajlm-463	110	6	mutations	mutation	NOUN
ajlm-463	110	7	in	in	ADP
ajlm-463	110	8	this	this	DET
ajlm-463	110	9	study	study	NOUN
ajlm-463	110	10	analysed	analyse	VERB
ajlm-463	110	11	by	by	ADP
ajlm-463	110	12	direct	direct	ADJ
ajlm-463	110	13	sequencing	sequencing	NOUN
ajlm-463	110	14	correlated	correlate	VERB
ajlm-463	110	15	well	well	ADV
ajlm-463	110	16	with	with	ADP
ajlm-463	110	17	rifampicin	rifampicin	VERB
ajlm-463	110	18	resistance	resistance	NOUN
ajlm-463	110	19	observed	observe	VERB
ajlm-463	110	20	on	on	ADP
ajlm-463	110	21	xpert	xpert	PROPN
ajlm-463	110	22	mtb	mtb	PROPN
ajlm-463	110	23	/	/	SYM
ajlm-463	110	24	rif	rif	PROPN
ajlm-463	110	25	.	.	PUNCT
ajlm-463	111	1	our	our	PRON
ajlm-463	111	2	findings	finding	NOUN
ajlm-463	111	3	reveal	reveal	VERB
ajlm-463	111	4	that	that	SCONJ
ajlm-463	111	5	86	86	NUM
ajlm-463	111	6	%	%	NOUN
ajlm-463	111	7	of	of	ADP
ajlm-463	111	8	all	all	DET
ajlm-463	111	9	rifampicin	rifampicin	NOUN
ajlm-463	111	10	-	-	PUNCT
ajlm-463	111	11	resistant	resistant	ADJ
ajlm-463	111	12	isolates	isolate	NOUN
ajlm-463	111	13	harboured	harbour	VERB
ajlm-463	111	14	mutations	mutation	NOUN
ajlm-463	111	15	in	in	ADP
ajlm-463	111	16	the	the	DET
ajlm-463	111	17	rrdr	rrdr	NOUN
ajlm-463	111	18	of	of	ADP
ajlm-463	111	19	the	the	DET
ajlm-463	111	20	rpob	rpob	ADJ
ajlm-463	111	21	gene	gene	NOUN
ajlm-463	111	22	with	with	ADP
ajlm-463	111	23	codon	codon	PROPN
ajlm-463	111	24	526	526	NUM
ajlm-463	111	25	(	(	PUNCT
ajlm-463	111	26	cac	cac	PROPN
ajlm-463	111	27	→	→	SYM
ajlm-463	111	28	tac	tac	PROPN
ajlm-463	111	29	)	)	PUNCT
ajlm-463	111	30	as	as	ADP
ajlm-463	111	31	the	the	DET
ajlm-463	111	32	most	most	ADV
ajlm-463	111	33	frequent	frequent	ADJ
ajlm-463	111	34	,	,	PUNCT
ajlm-463	111	35	followed	follow	VERB
ajlm-463	111	36	by	by	ADP
ajlm-463	111	37	codon	codon	NOUN
ajlm-463	111	38	531	531	NUM
ajlm-463	111	39	(	(	PUNCT
ajlm-463	111	40	tcg	tcg	NOUN
ajlm-463	111	41	→	→	SYM
ajlm-463	111	42	ttg	ttg	PROPN
ajlm-463	111	43	/	/	SYM
ajlm-463	111	44	tag	tag	NOUN
ajlm-463	111	45	)	)	PUNCT
ajlm-463	111	46	.	.	PUNCT
ajlm-463	112	1	by	by	ADP
ajlm-463	112	2	contrast	contrast	NOUN
ajlm-463	112	3	,	,	PUNCT
ajlm-463	112	4	mutations	mutation	NOUN
ajlm-463	112	5	were	be	AUX
ajlm-463	112	6	not	not	PART
ajlm-463	112	7	detected	detect	VERB
ajlm-463	112	8	in	in	ADP
ajlm-463	112	9	6/43	6/43	NUM
ajlm-463	112	10	(	(	PUNCT
ajlm-463	112	11	14	14	NUM
ajlm-463	112	12	%	%	NOUN
ajlm-463	112	13	)	)	PUNCT
ajlm-463	112	14	of	of	ADP
ajlm-463	112	15	the	the	DET
ajlm-463	112	16	strains	strain	NOUN
ajlm-463	112	17	following	follow	VERB
ajlm-463	112	18	nucleotide	nucleotide	ADJ
ajlm-463	112	19	sequencing	sequencing	NOUN
ajlm-463	112	20	.	.	PUNCT
ajlm-463	113	1	false	false	ADJ
ajlm-463	113	2	-	-	PUNCT
ajlm-463	113	3	positive	positive	ADJ
ajlm-463	113	4	rifampicin	rifampicin	VERB
ajlm-463	113	5	resistance	resistance	NOUN
ajlm-463	113	6	was	be	AUX
ajlm-463	113	7	most	most	ADV
ajlm-463	113	8	likely	likely	ADV
ajlm-463	113	9	considering	consider	VERB
ajlm-463	113	10	the	the	DET
ajlm-463	113	11	observed	observe	VERB
ajlm-463	113	12	wild	wild	ADJ
ajlm-463	113	13	-	-	PUNCT
ajlm-463	113	14	type	type	NOUN
ajlm-463	113	15	sequences	sequence	NOUN
ajlm-463	113	16	in	in	ADP
ajlm-463	113	17	these	these	DET
ajlm-463	113	18	strains	strain	NOUN
ajlm-463	113	19	.	.	PUNCT
ajlm-463	114	1	data	datum	NOUN
ajlm-463	114	2	on	on	ADP
ajlm-463	114	3	drug	drug	NOUN
ajlm-463	114	4	-	-	PUNCT
ajlm-463	114	5	resistance	resistance	NOUN
ajlm-463	114	6	mutations	mutation	NOUN
ajlm-463	114	7	involving	involve	VERB
ajlm-463	114	8	the	the	DET
ajlm-463	114	9	rrdr	rrdr	NOUN
ajlm-463	114	10	of	of	ADP
ajlm-463	114	11	the	the	DET
ajlm-463	114	12	rpob	rpob	PROPN
ajlm-463	114	13	gene	gene	NOUN
ajlm-463	114	14	,	,	PUNCT
ajlm-463	114	15	which	which	PRON
ajlm-463	114	16	relates	relate	VERB
ajlm-463	114	17	highly	highly	ADV
ajlm-463	114	18	to	to	ADP
ajlm-463	114	19	rifampicin	rifampicin	VERB
ajlm-463	114	20	resistance	resistance	NOUN
ajlm-463	114	21	,	,	PUNCT
ajlm-463	114	22	is	be	AUX
ajlm-463	114	23	new	new	ADJ
ajlm-463	114	24	for	for	ADP
ajlm-463	114	25	malawi	malawi	PROPN
ajlm-463	114	26	as	as	SCONJ
ajlm-463	114	27	no	no	DET
ajlm-463	114	28	previous	previous	ADJ
ajlm-463	114	29	studies	study	NOUN
ajlm-463	114	30	have	have	AUX
ajlm-463	114	31	analysed	analyse	VERB
ajlm-463	114	32	the	the	DET
ajlm-463	114	33	rpob	rpob	ADJ
ajlm-463	114	34	gene	gene	NOUN
ajlm-463	114	35	among	among	ADP
ajlm-463	114	36	tuberculosis	tuberculosis	NOUN
ajlm-463	114	37	strains	strain	NOUN
ajlm-463	114	38	circulating	circulate	VERB
ajlm-463	114	39	in	in	ADP
ajlm-463	114	40	the	the	DET
ajlm-463	114	41	country	country	NOUN
ajlm-463	114	42	.	.	PUNCT
ajlm-463	115	1	previous	previous	ADJ
ajlm-463	115	2	reports	report	NOUN
ajlm-463	115	3	demonstrated	demonstrate	VERB
ajlm-463	115	4	that	that	SCONJ
ajlm-463	115	5	strains	strain	NOUN
ajlm-463	115	6	requiring	require	VERB
ajlm-463	115	7	high	high	ADJ
ajlm-463	115	8	rifampicin	rifampicin	VERB
ajlm-463	115	9	concentrations	concentration	NOUN
ajlm-463	115	10	in	in	ADP
ajlm-463	115	11	phenotypic	phenotypic	ADJ
ajlm-463	115	12	dst	dst	NOUN
ajlm-463	115	13	have	have	AUX
ajlm-463	115	14	been	be	AUX
ajlm-463	115	15	associated	associate	VERB
ajlm-463	115	16	with	with	ADP
ajlm-463	115	17	mutations	mutation	NOUN
ajlm-463	115	18	at	at	ADP
ajlm-463	115	19	codons	codon	NOUN
ajlm-463	115	20	526	526	NUM
ajlm-463	115	21	,	,	PUNCT
ajlm-463	115	22	516	516	NUM
ajlm-463	115	23	,	,	PUNCT
ajlm-463	115	24	and	and	CCONJ
ajlm-463	115	25	531,26,27	531,26,27	NUM
ajlm-463	115	26	corroborating	corroborate	VERB
ajlm-463	115	27	that	that	SCONJ
ajlm-463	115	28	these	these	PRON
ajlm-463	115	29	are	be	AUX
ajlm-463	115	30	the	the	DET
ajlm-463	115	31	most	most	ADV
ajlm-463	115	32	prevalent	prevalent	ADJ
ajlm-463	115	33	rpob	rpob	ADJ
ajlm-463	115	34	mutations	mutation	NOUN
ajlm-463	115	35	worldwide.28	worldwide.28	NOUN
ajlm-463	115	36	several	several	ADJ
ajlm-463	115	37	studies	study	NOUN
ajlm-463	115	38	of	of	ADP
ajlm-463	115	39	rifampicin	rifampicin	NOUN
ajlm-463	115	40	-	-	PUNCT
ajlm-463	115	41	resistant	resistant	ADJ
ajlm-463	115	42	tuberculosis	tuberculosis	NOUN
ajlm-463	115	43	have	have	AUX
ajlm-463	115	44	reported	report	VERB
ajlm-463	115	45	the	the	DET
ajlm-463	115	46	presence	presence	NOUN
ajlm-463	115	47	of	of	ADP
ajlm-463	115	48	novel	novel	NOUN
ajlm-463	115	49	and	and	CCONJ
ajlm-463	115	50	common	common	ADJ
ajlm-463	115	51	rpob	rpob	ADJ
ajlm-463	115	52	gene	gene	NOUN
ajlm-463	115	53	mutations	mutation	NOUN
ajlm-463	115	54	,	,	PUNCT
ajlm-463	115	55	especially	especially	ADV
ajlm-463	115	56	in	in	ADP
ajlm-463	115	57	the	the	DET
ajlm-463	115	58	rrdr.29,30,31	rrdr.29,30,31	NOUN
ajlm-463	115	59	in	in	ADP
ajlm-463	115	60	addition	addition	NOUN
ajlm-463	115	61	,	,	PUNCT
ajlm-463	115	62	other	other	ADJ
ajlm-463	115	63	studies	study	NOUN
ajlm-463	115	64	have	have	AUX
ajlm-463	115	65	documented	document	VERB
ajlm-463	115	66	the	the	DET
ajlm-463	115	67	presence	presence	NOUN
ajlm-463	115	68	of	of	ADP
ajlm-463	115	69	common	common	ADJ
ajlm-463	115	70	and	and	CCONJ
ajlm-463	115	71	novel	novel	ADJ
ajlm-463	115	72	rpob	rpob	ADJ
ajlm-463	115	73	mutations	mutation	NOUN
ajlm-463	115	74	outside	outside	ADP
ajlm-463	115	75	the	the	DET
ajlm-463	115	76	rrdr.29,32	rrdr.29,32	NOUN
ajlm-463	115	77	based	base	VERB
ajlm-463	115	78	on	on	ADP
ajlm-463	115	79	our	our	PRON
ajlm-463	115	80	amplicon	amplicon	NOUN
ajlm-463	115	81	size	size	NOUN
ajlm-463	115	82	,	,	PUNCT
ajlm-463	115	83	we	we	PRON
ajlm-463	115	84	only	only	ADV
ajlm-463	115	85	evaluated	evaluate	VERB
ajlm-463	115	86	the	the	DET
ajlm-463	115	87	most	most	ADV
ajlm-463	115	88	frequently	frequently	ADV
ajlm-463	115	89	-	-	PUNCT
ajlm-463	115	90	mutated	mutate	VERB
ajlm-463	115	91	codons	codon	NOUN
ajlm-463	115	92	between	between	ADP
ajlm-463	115	93	positions	position	NOUN
ajlm-463	115	94	491–574	491–574	NUM
ajlm-463	115	95	,	,	PUNCT
ajlm-463	115	96	which	which	PRON
ajlm-463	115	97	include	include	VERB
ajlm-463	115	98	the	the	DET
ajlm-463	115	99	rrdr	rrdr	NOUN
ajlm-463	115	100	.	.	PUNCT
ajlm-463	116	1	the	the	DET
ajlm-463	116	2	contribution	contribution	NOUN
ajlm-463	116	3	of	of	ADP
ajlm-463	116	4	additional	additional	ADJ
ajlm-463	116	5	mutations	mutation	NOUN
ajlm-463	116	6	to	to	AUX
ajlm-463	116	7	resistance	resistance	NOUN
ajlm-463	116	8	at	at	ADP
ajlm-463	116	9	positions	position	NOUN
ajlm-463	116	10	outside	outside	ADP
ajlm-463	116	11	the	the	DET
ajlm-463	116	12	region	region	NOUN
ajlm-463	116	13	that	that	PRON
ajlm-463	116	14	was	be	AUX
ajlm-463	116	15	sequenced	sequence	VERB
ajlm-463	116	16	,	,	PUNCT
ajlm-463	116	17	for	for	ADP
ajlm-463	116	18	example	example	NOUN
ajlm-463	116	19	codon	codon	PROPN
ajlm-463	116	20	176	176	NUM
ajlm-463	116	21	,	,	PUNCT
ajlm-463	116	22	can	can	AUX
ajlm-463	116	23	not	not	PART
ajlm-463	116	24	be	be	AUX
ajlm-463	116	25	ruled	rule	VERB
ajlm-463	116	26	out	out	ADP
ajlm-463	116	27	.	.	PUNCT
ajlm-463	117	1	future	future	ADJ
ajlm-463	117	2	work	work	NOUN
ajlm-463	117	3	should	should	AUX
ajlm-463	117	4	focus	focus	VERB
ajlm-463	117	5	on	on	ADP
ajlm-463	117	6	sequencing	sequence	VERB
ajlm-463	117	7	the	the	DET
ajlm-463	117	8	entire	entire	ADJ
ajlm-463	117	9	rpob	rpob	ADJ
ajlm-463	117	10	gene	gene	NOUN
ajlm-463	117	11	.	.	PUNCT
ajlm-463	118	1	it	it	PRON
ajlm-463	118	2	is	be	AUX
ajlm-463	118	3	of	of	ADP
ajlm-463	118	4	particular	particular	ADJ
ajlm-463	118	5	interest	interest	NOUN
ajlm-463	118	6	that	that	PRON
ajlm-463	118	7	the	the	DET
ajlm-463	118	8	xpert	xpert	PROPN
ajlm-463	118	9	mtb	mtb	PROPN
ajlm-463	118	10	/	/	SYM
ajlm-463	118	11	rif	rif	PROPN
ajlm-463	118	12	assay	assay	PROPN
ajlm-463	118	13	detected	detect	VERB
ajlm-463	118	14	rifampicin	rifampicin	VERB
ajlm-463	118	15	resistance	resistance	NOUN
ajlm-463	118	16	in	in	ADP
ajlm-463	118	17	six	six	NUM
ajlm-463	118	18	isolates	isolate	NOUN
ajlm-463	118	19	,	,	PUNCT
ajlm-463	118	20	but	but	CCONJ
ajlm-463	118	21	partial	partial	ADJ
ajlm-463	118	22	sequencing	sequencing	NOUN
ajlm-463	118	23	of	of	ADP
ajlm-463	118	24	the	the	DET
ajlm-463	118	25	rpob	rpob	PROPN
ajlm-463	118	26	gene	gene	NOUN
ajlm-463	118	27	did	do	AUX
ajlm-463	118	28	not	not	PART
ajlm-463	118	29	detect	detect	VERB
ajlm-463	118	30	any	any	DET
ajlm-463	118	31	changes	change	NOUN
ajlm-463	118	32	in	in	ADP
ajlm-463	118	33	the	the	DET
ajlm-463	118	34	nucleotide	nucleotide	ADJ
ajlm-463	118	35	sequences	sequence	NOUN
ajlm-463	118	36	,	,	PUNCT
ajlm-463	118	37	such	such	ADJ
ajlm-463	118	38	that	that	SCONJ
ajlm-463	118	39	the	the	DET
ajlm-463	118	40	mechanisms	mechanism	NOUN
ajlm-463	118	41	/	/	SYM
ajlm-463	118	42	pathways	pathway	NOUN
ajlm-463	118	43	of	of	ADP
ajlm-463	118	44	resistance	resistance	NOUN
ajlm-463	118	45	of	of	ADP
ajlm-463	118	46	these	these	DET
ajlm-463	118	47	strains	strain	NOUN
ajlm-463	118	48	remain	remain	VERB
ajlm-463	118	49	unknown	unknown	ADJ
ajlm-463	118	50	.	.	PUNCT
ajlm-463	119	1	since	since	SCONJ
ajlm-463	119	2	unprocessed	unprocesse	VERB
ajlm-463	119	3	sputum	sputum	NOUN
ajlm-463	119	4	was	be	AUX
ajlm-463	119	5	not	not	PART
ajlm-463	119	6	sequenced	sequence	VERB
ajlm-463	119	7	,	,	PUNCT
ajlm-463	119	8	it	it	PRON
ajlm-463	119	9	was	be	AUX
ajlm-463	119	10	difficult	difficult	ADJ
ajlm-463	119	11	to	to	PART
ajlm-463	119	12	confidently	confidently	ADV
ajlm-463	119	13	exclude	exclude	VERB
ajlm-463	119	14	hetero	hetero	NOUN
ajlm-463	119	15	-	-	PUNCT
ajlm-463	119	16	resistance	resistance	NOUN
ajlm-463	119	17	in	in	ADP
ajlm-463	119	18	these	these	DET
ajlm-463	119	19	strains	strain	NOUN
ajlm-463	119	20	.	.	PUNCT
ajlm-463	120	1	in	in	ADP
ajlm-463	120	2	low	low	ADJ
ajlm-463	120	3	rifampicin	rifampicin	VERB
ajlm-463	120	4	-	-	PUNCT
ajlm-463	120	5	resistance	resistance	NOUN
ajlm-463	120	6	prevalence	prevalence	NOUN
ajlm-463	120	7	areas	area	NOUN
ajlm-463	120	8	,	,	PUNCT
ajlm-463	120	9	the	the	DET
ajlm-463	120	10	xpert	xpert	PROPN
ajlm-463	120	11	mtb	mtb	PROPN
ajlm-463	120	12	/	/	SYM
ajlm-463	120	13	rif	rif	PROPN
ajlm-463	120	14	assay	assay	PROPN
ajlm-463	120	15	would	would	AUX
ajlm-463	120	16	be	be	AUX
ajlm-463	120	17	expected	expect	VERB
ajlm-463	120	18	to	to	PART
ajlm-463	120	19	falsely	falsely	ADV
ajlm-463	120	20	diagnose	diagnose	VERB
ajlm-463	120	21	some	some	DET
ajlm-463	120	22	cases,8	cases,8	NOUN
ajlm-463	120	23	which	which	PRON
ajlm-463	120	24	could	could	AUX
ajlm-463	120	25	be	be	AUX
ajlm-463	120	26	the	the	DET
ajlm-463	120	27	case	case	NOUN
ajlm-463	120	28	with	with	ADP
ajlm-463	120	29	these	these	DET
ajlm-463	120	30	strains	strain	NOUN
ajlm-463	120	31	.	.	PUNCT
ajlm-463	121	1	sequencing	sequence	VERB
ajlm-463	121	2	the	the	DET
ajlm-463	121	3	entire	entire	ADJ
ajlm-463	121	4	rpob	rpob	ADJ
ajlm-463	121	5	gene	gene	NOUN
ajlm-463	121	6	might	might	AUX
ajlm-463	121	7	help	help	VERB
ajlm-463	121	8	to	to	PART
ajlm-463	121	9	understand	understand	VERB
ajlm-463	121	10	the	the	DET
ajlm-463	121	11	mechanism	mechanism	NOUN
ajlm-463	121	12	of	of	ADP
ajlm-463	121	13	resistance	resistance	NOUN
ajlm-463	121	14	of	of	ADP
ajlm-463	121	15	the	the	DET
ajlm-463	121	16	strains	strain	NOUN
ajlm-463	121	17	.	.	PUNCT
ajlm-463	122	1	in	in	ADP
ajlm-463	122	2	contrast	contrast	NOUN
ajlm-463	122	3	,	,	PUNCT
ajlm-463	122	4	results	result	NOUN
ajlm-463	122	5	obtained	obtain	VERB
ajlm-463	122	6	in	in	ADP
ajlm-463	122	7	swaziland	swaziland	PROPN
ajlm-463	122	8	show	show	VERB
ajlm-463	122	9	that	that	SCONJ
ajlm-463	122	10	the	the	DET
ajlm-463	122	11	xpert	xpert	PROPN
ajlm-463	122	12	mtb	mtb	PROPN
ajlm-463	122	13	/	/	SYM
ajlm-463	122	14	rif	rif	PROPN
ajlm-463	122	15	assay	assay	PROPN
ajlm-463	122	16	did	do	AUX
ajlm-463	122	17	not	not	PART
ajlm-463	122	18	detect	detect	VERB
ajlm-463	122	19	the	the	DET
ajlm-463	122	20	rpob	rpob	ADJ
ajlm-463	122	21	i491f	i491f	PROPN
ajlm-463	122	22	mutation	mutation	NOUN
ajlm-463	122	23	(	(	PUNCT
ajlm-463	122	24	outbreak	outbreak	NOUN
ajlm-463	122	25	strain	strain	VERB
ajlm-463	122	26	)	)	PUNCT
ajlm-463	122	27	in	in	ADP
ajlm-463	122	28	38/125	38/125	NUM
ajlm-463	122	29	(	(	PUNCT
ajlm-463	122	30	30	30	NUM
ajlm-463	122	31	%	%	NOUN
ajlm-463	122	32	)	)	PUNCT
ajlm-463	122	33	of	of	ADP
ajlm-463	122	34	the	the	DET
ajlm-463	122	35	isolates	isolate	NOUN
ajlm-463	122	36	tested	test	VERB
ajlm-463	122	37	as	as	ADP
ajlm-463	122	38	compared	compare	VERB
ajlm-463	122	39	to	to	ADP
ajlm-463	122	40	dna	dna	PROPN
ajlm-463	122	41	sequencing	sequencing	NOUN
ajlm-463	122	42	,	,	PUNCT
ajlm-463	122	43	raising	raise	VERB
ajlm-463	122	44	fears	fear	NOUN
ajlm-463	122	45	about	about	ADP
ajlm-463	122	46	the	the	DET
ajlm-463	122	47	assay	assay	NOUN
ajlm-463	122	48	’s	’s	PART
ajlm-463	122	49	unreliability	unreliability	NOUN
ajlm-463	122	50	due	due	ADP
ajlm-463	122	51	to	to	ADP
ajlm-463	122	52	under	under	ADP
ajlm-463	122	53	-	-	PUNCT
ajlm-463	122	54	diagnosis	diagnosis	NOUN
ajlm-463	122	55	and	and	CCONJ
ajlm-463	122	56	potential	potential	ADJ
ajlm-463	122	57	treatment	treatment	NOUN
ajlm-463	122	58	inadequacy	inadequacy	NOUN
ajlm-463	122	59	,	,	PUNCT
ajlm-463	122	60	since	since	SCONJ
ajlm-463	122	61	it	it	PRON
ajlm-463	122	62	does	do	AUX
ajlm-463	122	63	not	not	PART
ajlm-463	122	64	detect	detect	VERB
ajlm-463	122	65	mutations	mutation	NOUN
ajlm-463	122	66	outside	outside	ADP
ajlm-463	122	67	the	the	DET
ajlm-463	122	68	rrdr.33	rrdr.33	NOUN
ajlm-463	122	69	furthermore	furthermore	ADV
ajlm-463	122	70	,	,	PUNCT
ajlm-463	122	71	a	a	DET
ajlm-463	122	72	study	study	NOUN
ajlm-463	122	73	by	by	ADP
ajlm-463	122	74	theron	theron	PROPN
ajlm-463	122	75	et	et	PROPN
ajlm-463	122	76	al	al	PROPN
ajlm-463	122	77	.	.	PROPN
ajlm-463	122	78	observed	observe	VERB
ajlm-463	122	79	that	that	SCONJ
ajlm-463	122	80	five	five	NUM
ajlm-463	122	81	strains	strain	NOUN
ajlm-463	122	82	were	be	AUX
ajlm-463	122	83	rifampicin	rifampicin	VERB
ajlm-463	122	84	resistant	resistant	ADJ
ajlm-463	122	85	on	on	ADP
ajlm-463	122	86	xpert	xpert	PROPN
ajlm-463	122	87	mtb	mtb	PROPN
ajlm-463	122	88	/	/	SYM
ajlm-463	122	89	rif	rif	PROPN
ajlm-463	122	90	,	,	PUNCT
ajlm-463	122	91	rpob	rpob	ADJ
ajlm-463	122	92	sequencing	sequencing	NOUN
ajlm-463	122	93	and/or	and/or	CCONJ
ajlm-463	122	94	genotype	genotype	NOUN
ajlm-463	122	95	mtbdrplus	mtbdrplus	ADJ
ajlm-463	122	96	,	,	PUNCT
ajlm-463	122	97	but	but	CCONJ
ajlm-463	122	98	susceptible	susceptible	ADJ
ajlm-463	122	99	on	on	ADP
ajlm-463	122	100	phenotypic	phenotypic	ADJ
ajlm-463	122	101	dst.34	dst.34	NOUN
ajlm-463	122	102	it	it	PRON
ajlm-463	122	103	should	should	AUX
ajlm-463	122	104	be	be	AUX
ajlm-463	122	105	noted	note	VERB
ajlm-463	122	106	,	,	PUNCT
ajlm-463	122	107	however	however	ADV
ajlm-463	122	108	,	,	PUNCT
ajlm-463	122	109	that	that	SCONJ
ajlm-463	122	110	pcr	pcr	ADJ
ajlm-463	122	111	amplicons	amplicon	NOUN
ajlm-463	122	112	were	be	AUX
ajlm-463	122	113	different	different	ADJ
ajlm-463	122	114	in	in	ADP
ajlm-463	122	115	the	the	DET
ajlm-463	122	116	xpert	xpert	PROPN
ajlm-463	122	117	mtb	mtb	PROPN
ajlm-463	122	118	/	/	SYM
ajlm-463	122	119	rif	rif	PROPN
ajlm-463	122	120	assay	assay	NOUN
ajlm-463	122	121	versus	versus	ADP
ajlm-463	122	122	what	what	PRON
ajlm-463	122	123	was	be	AUX
ajlm-463	122	124	used	use	VERB
ajlm-463	122	125	for	for	ADP
ajlm-463	122	126	the	the	DET
ajlm-463	122	127	sanger	sanger	PROPN
ajlm-463	122	128	-	-	PUNCT
ajlm-463	122	129	based	base	VERB
ajlm-463	122	130	sequencing	sequencing	NOUN
ajlm-463	122	131	.	.	PUNCT
ajlm-463	123	1	the	the	DET
ajlm-463	123	2	probes	probe	NOUN
ajlm-463	123	3	may	may	AUX
ajlm-463	123	4	have	have	AUX
ajlm-463	123	5	bound	bind	VERB
ajlm-463	123	6	to	to	ADP
ajlm-463	123	7	minority	minority	NOUN
ajlm-463	123	8	variants	variant	NOUN
ajlm-463	123	9	in	in	ADP
ajlm-463	123	10	the	the	DET
ajlm-463	123	11	xpert	xpert	PROPN
ajlm-463	123	12	mtb	mtb	PROPN
ajlm-463	123	13	/	/	SYM
ajlm-463	123	14	rif	rif	NOUN
ajlm-463	123	15	amplicons	amplicon	NOUN
ajlm-463	123	16	,	,	PUNCT
ajlm-463	123	17	resulting	result	VERB
ajlm-463	123	18	in	in	ADP
ajlm-463	123	19	a	a	DET
ajlm-463	123	20	positive	positive	ADJ
ajlm-463	123	21	signal	signal	NOUN
ajlm-463	123	22	,	,	PUNCT
ajlm-463	123	23	whereas	whereas	SCONJ
ajlm-463	123	24	a	a	DET
ajlm-463	123	25	combination	combination	NOUN
ajlm-463	123	26	of	of	ADP
ajlm-463	123	27	pcr	pcr	ADJ
ajlm-463	123	28	bias	bias	NOUN
ajlm-463	123	29	and	and	CCONJ
ajlm-463	123	30	population	population	NOUN
ajlm-463	123	31	-	-	PUNCT
ajlm-463	123	32	based	base	VERB
ajlm-463	123	33	sanger	sanger	PROPN
ajlm-463	123	34	sequencing	sequence	VERB
ajlm-463	123	35	(	(	PUNCT
ajlm-463	123	36	where	where	SCONJ
ajlm-463	123	37	the	the	DET
ajlm-463	123	38	limit	limit	NOUN
ajlm-463	123	39	of	of	ADP
ajlm-463	123	40	detection	detection	NOUN
ajlm-463	123	41	is	be	AUX
ajlm-463	123	42	approximately	approximately	ADV
ajlm-463	123	43	20	20	NUM
ajlm-463	123	44	%	%	NOUN
ajlm-463	123	45	of	of	ADP
ajlm-463	123	46	the	the	DET
ajlm-463	123	47	quasispecies	quasispecie	NOUN
ajlm-463	123	48	and	and	CCONJ
ajlm-463	123	49	only	only	ADV
ajlm-463	123	50	the	the	DET
ajlm-463	123	51	predominant	predominant	ADJ
ajlm-463	123	52	population	population	NOUN
ajlm-463	123	53	is	be	AUX
ajlm-463	123	54	reported	report	VERB
ajlm-463	123	55	)	)	PUNCT
ajlm-463	123	56	might	might	AUX
ajlm-463	123	57	have	have	AUX
ajlm-463	123	58	resulted	result	VERB
ajlm-463	123	59	in	in	ADP
ajlm-463	123	60	only	only	ADV
ajlm-463	123	61	the	the	DET
ajlm-463	123	62	wild	wild	ADJ
ajlm-463	123	63	-	-	PUNCT
ajlm-463	123	64	type	type	NOUN
ajlm-463	123	65	sequence	sequence	NOUN
ajlm-463	123	66	being	be	AUX
ajlm-463	123	67	detected.35	detected.35	NOUN
ajlm-463	123	68	moreover	moreover	ADV
ajlm-463	123	69	,	,	PUNCT
ajlm-463	123	70	different	different	ADJ
ajlm-463	123	71	fitness	fitness	NOUN
ajlm-463	123	72	of	of	ADP
ajlm-463	123	73	drug	drug	NOUN
ajlm-463	123	74	-	-	PUNCT
ajlm-463	123	75	resistant	resistant	ADJ
ajlm-463	123	76	tuberculosis	tuberculosis	NOUN
ajlm-463	123	77	under	under	ADP
ajlm-463	123	78	culture	culture	NOUN
ajlm-463	123	79	conditions	condition	NOUN
ajlm-463	123	80	can	can	AUX
ajlm-463	123	81	allow	allow	VERB
ajlm-463	123	82	for	for	ADP
ajlm-463	123	83	the	the	DET
ajlm-463	123	84	outgrowth	outgrowth	NOUN
ajlm-463	123	85	of	of	ADP
ajlm-463	123	86	wild	wild	ADJ
ajlm-463	123	87	-	-	PUNCT
ajlm-463	123	88	type	type	NOUN
ajlm-463	123	89	tuberculosis,36	tuberculosis,36	NOUN
ajlm-463	123	90	accounting	account	VERB
ajlm-463	123	91	for	for	ADP
ajlm-463	123	92	the	the	DET
ajlm-463	123	93	discordant	discordant	ADJ
ajlm-463	123	94	results	result	NOUN
ajlm-463	123	95	between	between	ADP
ajlm-463	123	96	the	the	DET
ajlm-463	123	97	molecular	molecular	ADJ
ajlm-463	123	98	and	and	CCONJ
ajlm-463	123	99	phenotypic	phenotypic	ADJ
ajlm-463	123	100	assays	assay	NOUN
ajlm-463	123	101	.	.	PUNCT
ajlm-463	124	1	drug	drug	NOUN
ajlm-463	124	2	resistance	resistance	NOUN
ajlm-463	124	3	was	be	AUX
ajlm-463	124	4	detected	detect	VERB
ajlm-463	124	5	in	in	ADP
ajlm-463	124	6	some	some	DET
ajlm-463	124	7	new	new	ADJ
ajlm-463	124	8	tuberculosis	tuberculosis	NOUN
ajlm-463	124	9	cases	case	NOUN
ajlm-463	124	10	and	and	CCONJ
ajlm-463	124	11	these	these	DET
ajlm-463	124	12	results	result	NOUN
ajlm-463	124	13	were	be	AUX
ajlm-463	124	14	confirmed	confirm	VERB
ajlm-463	124	15	by	by	ADP
ajlm-463	124	16	detecting	detect	VERB
ajlm-463	124	17	mutations	mutation	NOUN
ajlm-463	124	18	in	in	ADP
ajlm-463	124	19	the	the	DET
ajlm-463	124	20	rrdr	rrdr	NOUN
ajlm-463	124	21	of	of	ADP
ajlm-463	124	22	the	the	DET
ajlm-463	124	23	rpob	rpob	ADJ
ajlm-463	124	24	gene	gene	NOUN
ajlm-463	124	25	.	.	PUNCT
ajlm-463	125	1	detecting	detect	VERB
ajlm-463	125	2	resistance	resistance	NOUN
ajlm-463	125	3	to	to	ADP
ajlm-463	125	4	rifampicin	rifampicin	VERB
ajlm-463	125	5	in	in	ADP
ajlm-463	125	6	new	new	ADJ
ajlm-463	125	7	tuberculosis	tuberculosis	NOUN
ajlm-463	125	8	cases	case	NOUN
ajlm-463	125	9	highlights	highlight	VERB
ajlm-463	125	10	the	the	DET
ajlm-463	125	11	need	need	NOUN
ajlm-463	125	12	for	for	ADP
ajlm-463	125	13	testing	test	VERB
ajlm-463	125	14	resistance	resistance	NOUN
ajlm-463	125	15	to	to	ADP
ajlm-463	125	16	drugs	drug	NOUN
ajlm-463	125	17	in	in	ADP
ajlm-463	125	18	this	this	DET
ajlm-463	125	19	category	category	NOUN
ajlm-463	125	20	especially	especially	ADV
ajlm-463	125	21	if	if	SCONJ
ajlm-463	125	22	the	the	DET
ajlm-463	125	23	patient	patient	NOUN
ajlm-463	125	24	was	be	AUX
ajlm-463	125	25	in	in	ADP
ajlm-463	125	26	contact	contact	NOUN
ajlm-463	125	27	with	with	ADP
ajlm-463	125	28	a	a	DET
ajlm-463	125	29	known	know	VERB
ajlm-463	125	30	mdr	mdr	NOUN
ajlm-463	125	31	tuberculosis	tuberculosis	NOUN
ajlm-463	125	32	patient	patient	NOUN
ajlm-463	125	33	.	.	PUNCT
ajlm-463	126	1	our	our	PRON
ajlm-463	126	2	results	result	NOUN
ajlm-463	126	3	show	show	VERB
ajlm-463	126	4	that	that	SCONJ
ajlm-463	126	5	the	the	DET
ajlm-463	126	6	prevalence	prevalence	NOUN
ajlm-463	126	7	of	of	ADP
ajlm-463	126	8	mutations	mutation	NOUN
ajlm-463	126	9	associated	associate	VERB
ajlm-463	126	10	with	with	ADP
ajlm-463	126	11	rifampicin	rifampicin	VERB
ajlm-463	126	12	resistance	resistance	NOUN
ajlm-463	126	13	among	among	ADP
ajlm-463	126	14	new	new	ADJ
ajlm-463	126	15	tuberculosis	tuberculosis	NOUN
ajlm-463	126	16	cases	case	NOUN
ajlm-463	126	17	was	be	AUX
ajlm-463	126	18	2.3	2.3	NUM
ajlm-463	126	19	%	%	NOUN
ajlm-463	126	20	.	.	PUNCT
ajlm-463	127	1	in	in	ADP
ajlm-463	127	2	malawi	malawi	PROPN
ajlm-463	127	3	,	,	PUNCT
ajlm-463	127	4	the	the	DET
ajlm-463	127	5	prevalence	prevalence	NOUN
ajlm-463	127	6	of	of	ADP
ajlm-463	127	7	mdr	mdr	PROPN
ajlm-463	127	8	tuberculosis	tuberculosis	NOUN
ajlm-463	127	9	is	be	AUX
ajlm-463	127	10	low	low	ADJ
ajlm-463	127	11	(	(	PUNCT
ajlm-463	127	12	0.4	0.4	NUM
ajlm-463	127	13	%	%	NOUN
ajlm-463	127	14	)	)	PUNCT
ajlm-463	127	15	among	among	ADP
ajlm-463	127	16	new	new	ADJ
ajlm-463	127	17	smear	smear	NOUN
ajlm-463	127	18	-	-	PUNCT
ajlm-463	127	19	positive	positive	ADJ
ajlm-463	127	20	cases	case	NOUN
ajlm-463	127	21	and	and	CCONJ
ajlm-463	127	22	is	be	AUX
ajlm-463	127	23	4.8	4.8	NUM
ajlm-463	127	24	%	%	NOUN
ajlm-463	127	25	among	among	ADP
ajlm-463	127	26	retreatment	retreatment	ADJ
ajlm-463	127	27	cases	case	NOUN
ajlm-463	127	28	.	.	PUNCT
ajlm-463	128	1	testing	test	VERB
ajlm-463	128	2	for	for	ADP
ajlm-463	128	3	tuberculosis	tuberculosis	NOUN
ajlm-463	128	4	drug	drug	NOUN
ajlm-463	128	5	resistance	resistance	NOUN
ajlm-463	128	6	in	in	ADP
ajlm-463	128	7	malawi	malawi	PROPN
ajlm-463	128	8	is	be	AUX
ajlm-463	128	9	not	not	PART
ajlm-463	128	10	routinely	routinely	ADV
ajlm-463	128	11	done	do	VERB
ajlm-463	128	12	except	except	SCONJ
ajlm-463	128	13	for	for	ADP
ajlm-463	128	14	those	those	PRON
ajlm-463	128	15	highly	highly	ADV
ajlm-463	128	16	suspected	suspect	VERB
ajlm-463	128	17	of	of	ADP
ajlm-463	128	18	drug	drug	NOUN
ajlm-463	128	19	resistance.37	resistance.37	NOUN
ajlm-463	128	20	results	result	NOUN
ajlm-463	128	21	obtained	obtain	VERB
ajlm-463	128	22	by	by	ADP
ajlm-463	128	23	the	the	DET
ajlm-463	128	24	xpert	xpert	PROPN
ajlm-463	128	25	mtb	mtb	PROPN
ajlm-463	128	26	/	/	SYM
ajlm-463	128	27	rif	rif	PROPN
ajlm-463	128	28	assay	assay	PROPN
ajlm-463	128	29	were	be	AUX
ajlm-463	128	30	in	in	ADP
ajlm-463	128	31	agreement	agreement	NOUN
ajlm-463	128	32	with	with	ADP
ajlm-463	128	33	genotype	genotype	NOUN
ajlm-463	128	34	mtbdrplus	mtbdrplus	ADJ
ajlm-463	128	35	results	result	NOUN
ajlm-463	128	36	on	on	ADP
ajlm-463	128	37	rifampicin	rifampicin	VERB
ajlm-463	128	38	resistance	resistance	NOUN
ajlm-463	128	39	,	,	PUNCT
ajlm-463	128	40	with	with	ADP
ajlm-463	128	41	an	an	DET
ajlm-463	128	42	exception	exception	NOUN
ajlm-463	128	43	of	of	ADP
ajlm-463	128	44	2/43	2/43	NUM
ajlm-463	128	45	(	(	PUNCT
ajlm-463	128	46	4.7	4.7	NUM
ajlm-463	128	47	%	%	NOUN
ajlm-463	128	48	)	)	PUNCT
ajlm-463	128	49	,	,	PUNCT
ajlm-463	128	50	which	which	PRON
ajlm-463	128	51	were	be	AUX
ajlm-463	128	52	sensitive	sensitive	ADJ
ajlm-463	128	53	on	on	ADP
ajlm-463	128	54	the	the	DET
ajlm-463	128	55	genotype	genotype	NOUN
ajlm-463	128	56	mtbdrplus	mtbdrplus	NOUN
ajlm-463	128	57	but	but	CCONJ
ajlm-463	128	58	rifampicin	rifampicin	VERB
ajlm-463	128	59	resistant	resistant	ADJ
ajlm-463	128	60	on	on	ADP
ajlm-463	128	61	xpert	xpert	PROPN
ajlm-463	128	62	mtb	mtb	PROPN
ajlm-463	128	63	/	/	SYM
ajlm-463	128	64	rif	rif	PROPN
ajlm-463	128	65	.	.	PUNCT
ajlm-463	129	1	ct	ct	PROPN
ajlm-463	129	2	values	value	NOUN
ajlm-463	129	3	of	of	ADP
ajlm-463	129	4	18.5	18.5	NUM
ajlm-463	129	5	and	and	CCONJ
ajlm-463	129	6	24.4	24.4	NUM
ajlm-463	129	7	on	on	ADP
ajlm-463	129	8	xpert	xpert	PROPN
ajlm-463	129	9	mtb	mtb	PROPN
ajlm-463	129	10	/	/	SYM
ajlm-463	129	11	rif	rif	PROPN
ajlm-463	129	12	,	,	PUNCT
ajlm-463	129	13	both	both	PRON
ajlm-463	129	14	on	on	ADP
ajlm-463	129	15	probe	probe	NOUN
ajlm-463	129	16	b	b	NUM
ajlm-463	129	17	,	,	PUNCT
ajlm-463	129	18	were	be	AUX
ajlm-463	129	19	interpreted	interpret	VERB
ajlm-463	129	20	as	as	ADP
ajlm-463	129	21	rifampicin	rifampicin	VERB
ajlm-463	129	22	resistant	resistant	ADJ
ajlm-463	129	23	.	.	PUNCT
ajlm-463	130	1	mixed	mixed	ADJ
ajlm-463	130	2	infection	infection	NOUN
ajlm-463	130	3	with	with	ADP
ajlm-463	130	4	multiple	multiple	ADJ
ajlm-463	130	5	tuberculosis	tuberculosis	NOUN
ajlm-463	130	6	strains	strain	NOUN
ajlm-463	130	7	was	be	AUX
ajlm-463	130	8	excluded	exclude	VERB
ajlm-463	130	9	in	in	ADP
ajlm-463	130	10	these	these	DET
ajlm-463	130	11	strains	strain	NOUN
ajlm-463	130	12	given	give	VERB
ajlm-463	130	13	the	the	DET
ajlm-463	130	14	wild	wild	ADJ
ajlm-463	130	15	-	-	PUNCT
ajlm-463	130	16	type	type	NOUN
ajlm-463	130	17	rpob	rpob	ADJ
ajlm-463	130	18	gene	gene	NOUN
ajlm-463	130	19	sequences	sequence	NOUN
ajlm-463	130	20	and	and	CCONJ
ajlm-463	130	21	no	no	DET
ajlm-463	130	22	observed	observed	ADJ
ajlm-463	130	23	underlying	underlie	VERB
ajlm-463	130	24	peaks	peak	NOUN
ajlm-463	130	25	on	on	ADP
ajlm-463	130	26	the	the	DET
ajlm-463	130	27	dna	dna	PROPN
ajlm-463	130	28	sequence	sequence	NOUN
ajlm-463	130	29	chromatograms	chromatogram	VERB
ajlm-463	130	30	.	.	PUNCT
ajlm-463	131	1	phenotypic	phenotypic	ADJ
ajlm-463	131	2	dst	dst	PROPN
ajlm-463	131	3	is	be	AUX
ajlm-463	131	4	difficult	difficult	ADJ
ajlm-463	131	5	to	to	PART
ajlm-463	131	6	standardise	standardise	VERB
ajlm-463	131	7	and	and	CCONJ
ajlm-463	131	8	expensive	expensive	ADJ
ajlm-463	131	9	and	and	CCONJ
ajlm-463	131	10	time	time	NOUN
ajlm-463	131	11	-	-	PUNCT
ajlm-463	131	12	consuming	consume	VERB
ajlm-463	131	13	to	to	PART
ajlm-463	131	14	maintain	maintain	VERB
ajlm-463	131	15	routinely	routinely	ADV
ajlm-463	131	16	.	.	PUNCT
ajlm-463	132	1	in	in	ADP
ajlm-463	132	2	the	the	DET
ajlm-463	132	3	absence	absence	NOUN
ajlm-463	132	4	of	of	ADP
ajlm-463	132	5	molecular	molecular	ADJ
ajlm-463	132	6	techniques	technique	NOUN
ajlm-463	132	7	,	,	PUNCT
ajlm-463	132	8	several	several	ADJ
ajlm-463	132	9	critical	critical	ADJ
ajlm-463	132	10	questions	question	NOUN
ajlm-463	132	11	about	about	ADP
ajlm-463	132	12	tuberculosis	tuberculosis	NOUN
ajlm-463	132	13	remain	remain	VERB
ajlm-463	132	14	unanswered	unanswered	ADJ
ajlm-463	132	15	,	,	PUNCT
ajlm-463	132	16	including	include	VERB
ajlm-463	132	17	recognition	recognition	NOUN
ajlm-463	132	18	of	of	ADP
ajlm-463	132	19	acquisition	acquisition	NOUN
ajlm-463	132	20	of	of	ADP
ajlm-463	132	21	drug	drug	NOUN
ajlm-463	132	22	resistance	resistance	NOUN
ajlm-463	132	23	resulting	result	VERB
ajlm-463	132	24	from	from	ADP
ajlm-463	132	25	gene	gene	NOUN
ajlm-463	132	26	mutations	mutation	NOUN
ajlm-463	132	27	versus	versus	ADP
ajlm-463	132	28	transmission	transmission	NOUN
ajlm-463	132	29	of	of	ADP
ajlm-463	132	30	drug	drug	NOUN
ajlm-463	132	31	resistant	resistant	ADJ
ajlm-463	132	32	strains.38	strains.38	NOUN
ajlm-463	132	33	limitations	limitation	VERB
ajlm-463	132	34	the	the	DET
ajlm-463	132	35	relatively	relatively	ADV
ajlm-463	132	36	small	small	ADJ
ajlm-463	132	37	number	number	NOUN
ajlm-463	132	38	of	of	ADP
ajlm-463	132	39	rifampicin	rifampicin	VERB
ajlm-463	132	40	-	-	PUNCT
ajlm-463	132	41	resistant	resistant	ADJ
ajlm-463	132	42	samples	sample	NOUN
ajlm-463	132	43	observed	observe	VERB
ajlm-463	132	44	in	in	ADP
ajlm-463	132	45	the	the	DET
ajlm-463	132	46	current	current	ADJ
ajlm-463	132	47	study	study	NOUN
ajlm-463	132	48	limited	limit	VERB
ajlm-463	132	49	our	our	PRON
ajlm-463	132	50	ability	ability	NOUN
ajlm-463	132	51	to	to	PART
ajlm-463	132	52	establish	establish	VERB
ajlm-463	132	53	the	the	DET
ajlm-463	132	54	overall	overall	ADJ
ajlm-463	132	55	prevalence	prevalence	NOUN
ajlm-463	132	56	of	of	ADP
ajlm-463	132	57	rpob	rpob	ADJ
ajlm-463	132	58	gene	gene	NOUN
ajlm-463	132	59	mutations	mutation	NOUN
ajlm-463	132	60	in	in	ADP
ajlm-463	132	61	tuberculosis	tuberculosis	NOUN
ajlm-463	132	62	strains	strain	NOUN
ajlm-463	132	63	circulating	circulate	VERB
ajlm-463	132	64	in	in	ADP
ajlm-463	132	65	malawi	malawi	PROPN
ajlm-463	132	66	.	.	PUNCT
ajlm-463	133	1	moreover	moreover	ADV
ajlm-463	133	2	,	,	PUNCT
ajlm-463	133	3	we	we	PRON
ajlm-463	133	4	sequenced	sequence	VERB
ajlm-463	133	5	only	only	ADV
ajlm-463	133	6	an	an	DET
ajlm-463	133	7	approximately	approximately	ADV
ajlm-463	133	8	450	450	NUM
ajlm-463	133	9	bp	bp	PROPN
ajlm-463	133	10	amplicon	amplicon	NOUN
ajlm-463	133	11	;	;	PUNCT
ajlm-463	133	12	thus	thus	ADV
ajlm-463	133	13	,	,	PUNCT
ajlm-463	133	14	the	the	DET
ajlm-463	133	15	contribution	contribution	NOUN
ajlm-463	133	16	of	of	ADP
ajlm-463	133	17	mutations	mutation	NOUN
ajlm-463	133	18	in	in	ADP
ajlm-463	133	19	regions	region	NOUN
ajlm-463	133	20	outside	outside	ADP
ajlm-463	133	21	of	of	ADP
ajlm-463	133	22	the	the	DET
ajlm-463	133	23	amplicon	amplicon	NOUN
ajlm-463	133	24	sequenced	sequence	VERB
ajlm-463	133	25	to	to	ADP
ajlm-463	133	26	overall	overall	ADJ
ajlm-463	133	27	resistance	resistance	NOUN
ajlm-463	133	28	could	could	AUX
ajlm-463	133	29	not	not	PART
ajlm-463	133	30	be	be	AUX
ajlm-463	133	31	determined	determine	VERB
ajlm-463	133	32	.	.	PUNCT
ajlm-463	134	1	with	with	ADP
ajlm-463	134	2	the	the	DET
ajlm-463	134	3	available	available	ADJ
ajlm-463	134	4	data	datum	NOUN
ajlm-463	134	5	,	,	PUNCT
ajlm-463	134	6	an	an	DET
ajlm-463	134	7	assessment	assessment	NOUN
ajlm-463	134	8	of	of	ADP
ajlm-463	134	9	the	the	DET
ajlm-463	134	10	epidemiological	epidemiological	ADJ
ajlm-463	134	11	link	link	NOUN
ajlm-463	134	12	between	between	ADP
ajlm-463	134	13	the	the	DET
ajlm-463	134	14	rifampicin	rifampicin	NOUN
ajlm-463	134	15	-	-	PUNCT
ajlm-463	134	16	resistant	resistant	ADJ
ajlm-463	134	17	strains	strain	NOUN
ajlm-463	134	18	was	be	AUX
ajlm-463	134	19	not	not	PART
ajlm-463	134	20	possible	possible	ADJ
ajlm-463	134	21	,	,	PUNCT
ajlm-463	134	22	as	as	SCONJ
ajlm-463	134	23	such	such	ADJ
ajlm-463	134	24	further	further	ADJ
ajlm-463	134	25	molecular	molecular	ADJ
ajlm-463	134	26	cluster	cluster	NOUN
ajlm-463	134	27	analysis	analysis	NOUN
ajlm-463	134	28	is	be	AUX
ajlm-463	134	29	still	still	ADV
ajlm-463	134	30	required	require	VERB
ajlm-463	134	31	to	to	PART
ajlm-463	134	32	determine	determine	VERB
ajlm-463	134	33	transmission	transmission	NOUN
ajlm-463	134	34	dynamics	dynamic	NOUN
ajlm-463	134	35	of	of	ADP
ajlm-463	134	36	the	the	DET
ajlm-463	134	37	mutated	mutate	VERB
ajlm-463	134	38	strains	strain	NOUN
ajlm-463	134	39	.	.	PUNCT
ajlm-463	135	1	future	future	ADJ
ajlm-463	135	2	studies	study	NOUN
ajlm-463	135	3	should	should	AUX
ajlm-463	135	4	consider	consider	VERB
ajlm-463	135	5	performing	perform	VERB
ajlm-463	135	6	phenotypic	phenotypic	ADJ
ajlm-463	135	7	dst	dst	NOUN
ajlm-463	135	8	to	to	PART
ajlm-463	135	9	detect	detect	VERB
ajlm-463	135	10	mutations	mutation	NOUN
ajlm-463	135	11	outside	outside	ADP
ajlm-463	135	12	the	the	DET
ajlm-463	135	13	rrdr	rrdr	NOUN
ajlm-463	135	14	(	(	PUNCT
ajlm-463	135	15	full	full	ADJ
ajlm-463	135	16	length	length	NOUN
ajlm-463	135	17	rpob	rpob	PROPN
ajlm-463	135	18	gene	gene	NOUN
ajlm-463	135	19	)	)	PUNCT
ajlm-463	135	20	and	and	CCONJ
ajlm-463	135	21	compare	compare	VERB
ajlm-463	135	22	to	to	ADP
ajlm-463	135	23	dna	dna	PROPN
ajlm-463	135	24	sequencing	sequencing	NOUN
ajlm-463	135	25	,	,	PUNCT
ajlm-463	135	26	considering	consider	VERB
ajlm-463	135	27	that	that	SCONJ
ajlm-463	135	28	sanger	sanger	PROPN
ajlm-463	135	29	sequencing	sequencing	NOUN
ajlm-463	135	30	has	have	VERB
ajlm-463	135	31	a	a	DET
ajlm-463	135	32	limit	limit	NOUN
ajlm-463	135	33	of	of	ADP
ajlm-463	135	34	detection	detection	NOUN
ajlm-463	135	35	where	where	SCONJ
ajlm-463	135	36	the	the	DET
ajlm-463	135	37	minority	minority	NOUN
ajlm-463	135	38	population	population	NOUN
ajlm-463	135	39	may	may	AUX
ajlm-463	135	40	not	not	PART
ajlm-463	135	41	be	be	AUX
ajlm-463	135	42	detected	detect	VERB
ajlm-463	135	43	.	.	PUNCT
ajlm-463	136	1	conclusion	conclusion	NOUN
ajlm-463	136	2	the	the	DET
ajlm-463	136	3	chain	chain	NOUN
ajlm-463	136	4	termination	termination	NOUN
ajlm-463	136	5	dna	dna	NOUN
ajlm-463	136	6	sequencing	sequencing	NOUN
ajlm-463	136	7	employed	employ	VERB
ajlm-463	136	8	in	in	ADP
ajlm-463	136	9	this	this	DET
ajlm-463	136	10	study	study	NOUN
ajlm-463	136	11	is	be	AUX
ajlm-463	136	12	a	a	DET
ajlm-463	136	13	standard	standard	ADJ
ajlm-463	136	14	method	method	NOUN
ajlm-463	136	15	for	for	ADP
ajlm-463	136	16	the	the	DET
ajlm-463	136	17	determination	determination	NOUN
ajlm-463	136	18	of	of	ADP
ajlm-463	136	19	nucleotide	nucleotide	ADJ
ajlm-463	136	20	sequences	sequence	NOUN
ajlm-463	136	21	.	.	PUNCT
ajlm-463	137	1	it	it	PRON
ajlm-463	137	2	is	be	AUX
ajlm-463	137	3	conclusive	conclusive	ADJ
ajlm-463	137	4	and	and	CCONJ
ajlm-463	137	5	can	can	AUX
ajlm-463	137	6	be	be	AUX
ajlm-463	137	7	used	use	VERB
ajlm-463	137	8	to	to	PART
ajlm-463	137	9	confirm	confirm	VERB
ajlm-463	137	10	rifampicin	rifampicin	VERB
ajlm-463	137	11	resistance	resistance	NOUN
ajlm-463	137	12	obtained	obtain	VERB
ajlm-463	137	13	by	by	ADP
ajlm-463	137	14	other	other	ADJ
ajlm-463	137	15	assays	assay	NOUN
ajlm-463	137	16	,	,	PUNCT
ajlm-463	137	17	including	include	VERB
ajlm-463	137	18	the	the	DET
ajlm-463	137	19	xpert	xpert	PROPN
ajlm-463	137	20	mtb	mtb	PROPN
ajlm-463	137	21	/	/	SYM
ajlm-463	137	22	rif	rif	PROPN
ajlm-463	137	23	assay	assay	NOUN
ajlm-463	137	24	,	,	PUNCT
ajlm-463	137	25	despite	despite	SCONJ
ajlm-463	137	26	having	have	VERB
ajlm-463	137	27	a	a	DET
ajlm-463	137	28	limit	limit	NOUN
ajlm-463	137	29	of	of	ADP
ajlm-463	137	30	detection	detection	NOUN
ajlm-463	137	31	with	with	ADP
ajlm-463	137	32	minority	minority	NOUN
ajlm-463	137	33	resistant	resistant	ADJ
ajlm-463	137	34	populations	population	NOUN
ajlm-463	137	35	.	.	PUNCT
ajlm-463	138	1	although	although	SCONJ
ajlm-463	138	2	phenotypic	phenotypic	ADJ
ajlm-463	138	3	dst	dst	NOUN
ajlm-463	138	4	is	be	AUX
ajlm-463	138	5	recommended	recommend	VERB
ajlm-463	138	6	to	to	PART
ajlm-463	138	7	verify	verify	VERB
ajlm-463	138	8	rifampicin	rifampicin	VERB
ajlm-463	138	9	resistance	resistance	NOUN
ajlm-463	138	10	when	when	SCONJ
ajlm-463	138	11	using	use	VERB
ajlm-463	138	12	xpert	xpert	PROPN
ajlm-463	138	13	mtb	mtb	PROPN
ajlm-463	138	14	/	/	SYM
ajlm-463	138	15	rif	rif	PROPN
ajlm-463	138	16	,	,	PUNCT
ajlm-463	138	17	dna	dna	PROPN
ajlm-463	138	18	sequencing	sequencing	NOUN
ajlm-463	138	19	can	can	AUX
ajlm-463	138	20	be	be	AUX
ajlm-463	138	21	used	use	VERB
ajlm-463	138	22	to	to	PART
ajlm-463	138	23	detect	detect	VERB
ajlm-463	138	24	the	the	DET
ajlm-463	138	25	frequency	frequency	NOUN
ajlm-463	138	26	and	and	CCONJ
ajlm-463	138	27	exact	exact	ADJ
ajlm-463	138	28	site	site	NOUN
ajlm-463	138	29	of	of	ADP
ajlm-463	138	30	mutations	mutation	NOUN
ajlm-463	138	31	in	in	ADP
ajlm-463	138	32	the	the	DET
ajlm-463	138	33	rrdr	rrdr	NOUN
ajlm-463	138	34	.	.	PUNCT
ajlm-463	139	1	all	all	DET
ajlm-463	139	2	tuberculosis	tuberculosis	NOUN
ajlm-463	139	3	strains	strain	NOUN
ajlm-463	139	4	with	with	ADP
ajlm-463	139	5	mutations	mutation	NOUN
ajlm-463	139	6	in	in	ADP
ajlm-463	139	7	the	the	DET
ajlm-463	139	8	current	current	ADJ
ajlm-463	139	9	study	study	NOUN
ajlm-463	139	10	had	have	VERB
ajlm-463	139	11	one	one	NUM
ajlm-463	139	12	of	of	ADP
ajlm-463	139	13	the	the	DET
ajlm-463	139	14	previously	previously	ADV
ajlm-463	139	15	-	-	PUNCT
ajlm-463	139	16	described	describe	VERB
ajlm-463	139	17	rpob	rpob	ADJ
ajlm-463	139	18	gene	gene	NOUN
ajlm-463	139	19	mutations	mutation	NOUN
ajlm-463	139	20	containing	contain	VERB
ajlm-463	139	21	nucleotide	nucleotide	ADJ
ajlm-463	139	22	changes	change	NOUN
ajlm-463	139	23	.	.	PUNCT
ajlm-463	140	1	no	no	DET
ajlm-463	140	2	new	new	ADJ
ajlm-463	140	3	mutations	mutation	NOUN
ajlm-463	140	4	were	be	AUX
ajlm-463	140	5	identified	identify	VERB
ajlm-463	140	6	.	.	PUNCT
ajlm-463	141	1	findings	finding	NOUN
ajlm-463	141	2	from	from	ADP
ajlm-463	141	3	this	this	DET
ajlm-463	141	4	study	study	NOUN
ajlm-463	141	5	emphasise	emphasise	VERB
ajlm-463	141	6	the	the	DET
ajlm-463	141	7	need	need	NOUN
ajlm-463	141	8	for	for	SCONJ
ajlm-463	141	9	a	a	DET
ajlm-463	141	10	national	national	ADJ
ajlm-463	141	11	representation	representation	NOUN
ajlm-463	141	12	of	of	ADP
ajlm-463	141	13	sputum	sputum	NOUN
ajlm-463	141	14	specimens	specimen	NOUN
ajlm-463	141	15	from	from	ADP
ajlm-463	141	16	tuberculosis	tuberculosis	NOUN
ajlm-463	141	17	-	-	PUNCT
ajlm-463	141	18	infected	infect	VERB
ajlm-463	141	19	patients	patient	NOUN
ajlm-463	141	20	to	to	PART
ajlm-463	141	21	assess	assess	VERB
ajlm-463	141	22	the	the	DET
ajlm-463	141	23	magnitude	magnitude	NOUN
ajlm-463	141	24	of	of	ADP
ajlm-463	141	25	tuberculosis	tuberculosis	NOUN
ajlm-463	141	26	rpob	rpob	ADJ
ajlm-463	141	27	gene	gene	NOUN
ajlm-463	141	28	mutations	mutation	NOUN
ajlm-463	141	29	that	that	PRON
ajlm-463	141	30	are	be	AUX
ajlm-463	141	31	responsible	responsible	ADJ
ajlm-463	141	32	for	for	ADP
ajlm-463	141	33	rifampicin	rifampicin	VERB
ajlm-463	141	34	resistance	resistance	NOUN
ajlm-463	141	35	in	in	ADP
ajlm-463	141	36	malawi	malawi	PROPN
ajlm-463	141	37	.	.	PUNCT
ajlm-463	142	1	acknowledgements	acknowledgement	NOUN
ajlm-463	142	2	the	the	DET
ajlm-463	142	3	authors	author	NOUN
ajlm-463	142	4	thank	thank	VERB
ajlm-463	142	5	the	the	DET
ajlm-463	142	6	unc	unc	PROPN
ajlm-463	142	7	project	project	PROPN
ajlm-463	142	8	laboratory	laboratory	NOUN
ajlm-463	142	9	staff	staff	NOUN
ajlm-463	142	10	,	,	PUNCT
ajlm-463	142	11	national	national	ADJ
ajlm-463	142	12	tuberculosis	tuberculosis	NOUN
ajlm-463	142	13	reference	reference	NOUN
ajlm-463	142	14	laboratory	laboratory	NOUN
ajlm-463	142	15	(	(	PUNCT
ajlm-463	142	16	malawi	malawi	PROPN
ajlm-463	142	17	)	)	PUNCT
ajlm-463	142	18	and	and	CCONJ
ajlm-463	142	19	laboratory	laboratory	NOUN
ajlm-463	142	20	staff	staff	NOUN
ajlm-463	142	21	at	at	ADP
ajlm-463	142	22	the	the	DET
ajlm-463	142	23	hiv	hiv	PROPN
ajlm-463	142	24	genotyping	genotype	VERB
ajlm-463	142	25	laboratory	laboratory	NOUN
ajlm-463	142	26	at	at	ADP
ajlm-463	142	27	university	university	NOUN
ajlm-463	142	28	of	of	ADP
ajlm-463	142	29	the	the	DET
ajlm-463	142	30	witwatersrand	witwatersrand	NOUN
ajlm-463	142	31	for	for	ADP
ajlm-463	142	32	assisting	assist	VERB
ajlm-463	142	33	with	with	ADP
ajlm-463	142	34	the	the	DET
ajlm-463	142	35	study	study	NOUN
ajlm-463	142	36	.	.	PUNCT
ajlm-463	143	1	competing	compete	VERB
ajlm-463	143	2	interests	interest	NOUN
ajlm-463	143	3	the	the	DET
ajlm-463	143	4	authors	author	NOUN
ajlm-463	143	5	declare	declare	VERB
ajlm-463	143	6	that	that	SCONJ
ajlm-463	143	7	they	they	PRON
ajlm-463	143	8	have	have	VERB
ajlm-463	143	9	no	no	DET
ajlm-463	143	10	financial	financial	ADJ
ajlm-463	143	11	or	or	CCONJ
ajlm-463	143	12	personal	personal	ADJ
ajlm-463	143	13	relationships	relationship	NOUN
ajlm-463	143	14	which	which	PRON
ajlm-463	143	15	may	may	AUX
ajlm-463	143	16	have	have	AUX
ajlm-463	143	17	inappropriately	inappropriately	ADV
ajlm-463	143	18	influenced	influence	VERB
ajlm-463	143	19	them	they	PRON
ajlm-463	143	20	in	in	ADP
ajlm-463	143	21	writing	write	VERB
ajlm-463	143	22	this	this	DET
ajlm-463	143	23	article	article	NOUN
ajlm-463	143	24	.	.	PUNCT
ajlm-463	144	1	sources	source	NOUN
ajlm-463	144	2	of	of	ADP
ajlm-463	144	3	support	support	NOUN
ajlm-463	144	4	this	this	DET
ajlm-463	144	5	project	project	NOUN
ajlm-463	144	6	was	be	AUX
ajlm-463	144	7	funded	fund	VERB
ajlm-463	144	8	by	by	ADP
ajlm-463	144	9	the	the	DET
ajlm-463	144	10	national	national	PROPN
ajlm-463	144	11	commission	commission	PROPN
ajlm-463	144	12	for	for	ADP
ajlm-463	144	13	science	science	NOUN
ajlm-463	144	14	and	and	CCONJ
ajlm-463	144	15	technology	technology	NOUN
ajlm-463	144	16	(	(	PUNCT
ajlm-463	144	17	malawi	malawi	PROPN
ajlm-463	144	18	)	)	PUNCT
ajlm-463	144	19	through	through	ADP
ajlm-463	144	20	the	the	DET
ajlm-463	144	21	health	health	NOUN
ajlm-463	144	22	research	research	NOUN
ajlm-463	144	23	capacity	capacity	NOUN
ajlm-463	144	24	strengthening	strengthen	VERB
ajlm-463	144	25	initiative	initiative	NOUN
ajlm-463	144	26	(	(	PUNCT
ajlm-463	144	27	hrcsi	hrcsi	PROPN
ajlm-463	144	28	)	)	PUNCT
ajlm-463	144	29	.	.	PUNCT
ajlm-463	145	1	additional	additional	ADJ
ajlm-463	145	2	funds	fund	NOUN
ajlm-463	145	3	were	be	AUX
ajlm-463	145	4	made	make	VERB
ajlm-463	145	5	available	available	ADJ
ajlm-463	145	6	by	by	ADP
ajlm-463	145	7	the	the	DET
ajlm-463	145	8	unc	unc	PROPN
ajlm-463	145	9	project	project	PROPN
ajlm-463	145	10	(	(	PUNCT
ajlm-463	145	11	malawi	malawi	PROPN
ajlm-463	145	12	)	)	PUNCT
ajlm-463	145	13	,	,	PUNCT
ajlm-463	145	14	unc	unc	PROPN
ajlm-463	145	15	fogarty	fogarty	PROPN
ajlm-463	145	16	aitrp	aitrp	PROPN
ajlm-463	145	17	(	(	PUNCT
ajlm-463	145	18	d43	d43	PROPN
ajlm-463	145	19	tw001039	tw001039	PROPN
ajlm-463	145	20	)	)	PUNCT
ajlm-463	145	21	,	,	PUNCT
ajlm-463	145	22	unc	unc	PROPN
ajlm-463	145	23	centre	centre	PROPN
ajlm-463	145	24	for	for	ADP
ajlm-463	145	25	aids	aids	PROPN
ajlm-463	145	26	research	research	NOUN
ajlm-463	145	27	(	(	PUNCT
ajlm-463	145	28	p30	p30	NOUN
ajlm-463	145	29	ai50410	ai50410	PROPN
ajlm-463	145	30	)	)	PUNCT
ajlm-463	145	31	and	and	CCONJ
ajlm-463	145	32	malawi	malawi	VERB
ajlm-463	145	33	hiv	hiv	PROPN
ajlm-463	145	34	implementation	implementation	PROPN
ajlm-463	145	35	research	research	NOUN
ajlm-463	145	36	scientist	scientist	NOUN
ajlm-463	145	37	program	program	NOUN
ajlm-463	145	38	(	(	PUNCT
ajlm-463	145	39	d43	d43	NOUN
ajlm-463	145	40	tw010060	tw010060	NOUN
ajlm-463	145	41	)	)	PUNCT
ajlm-463	145	42	.	.	PUNCT
ajlm-463	146	1	authors	author	NOUN
ajlm-463	146	2	’	'	PUNCT
ajlm-463	146	3	contributions	contribution	NOUN
ajlm-463	146	4	t.c	t.c	PROPN
ajlm-463	146	5	.	.	PROPN
ajlm-463	146	6	conceptualised	conceptualise	VERB
ajlm-463	146	7	the	the	DET
ajlm-463	146	8	study	study	NOUN
ajlm-463	146	9	.	.	PUNCT
ajlm-463	147	1	t.c	t.c	PROPN
ajlm-463	147	2	.	.	PROPN
ajlm-463	147	3	,	,	PUNCT
ajlm-463	147	4	i.k	i.k	PROPN
ajlm-463	147	5	.	.	PROPN
ajlm-463	147	6	,	,	PUNCT
ajlm-463	147	7	n.n	n.n	PROPN
ajlm-463	147	8	.	.	PROPN
ajlm-463	147	9	and	and	CCONJ
ajlm-463	147	10	i.t	i.t	PROPN
ajlm-463	147	11	.	.	PROPN
ajlm-463	147	12	performed	perform	VERB
ajlm-463	147	13	the	the	DET
ajlm-463	147	14	experiments	experiment	NOUN
ajlm-463	147	15	.	.	PUNCT
ajlm-463	148	1	m.h	m.h	AUX
ajlm-463	148	2	.	.	PROPN
ajlm-463	148	3	,	,	PUNCT
ajlm-463	148	4	l.s	l.s	PROPN
ajlm-463	148	5	.	.	PROPN
ajlm-463	148	6	,	,	PUNCT
ajlm-463	148	7	w.s	w.s	PROPN
ajlm-463	148	8	.	.	PROPN
ajlm-463	148	9	,	,	PUNCT
ajlm-463	148	10	f.n	f.n	PROPN
ajlm-463	148	11	.	.	PROPN
ajlm-463	148	12	,	,	PUNCT
ajlm-463	148	13	r.k	r.k	PROPN
ajlm-463	148	14	.	.	PROPN
ajlm-463	148	15	,	,	PUNCT
ajlm-463	148	16	m.a.p	m.a.p	PROPN
ajlm-463	148	17	.	.	PROPN
ajlm-463	148	18	,	,	PUNCT
ajlm-463	148	19	j.m	j.m	AUX
ajlm-463	148	20	.	.	PROPN
ajlm-463	148	21	and	and	CCONJ
ajlm-463	148	22	i.f.h	i.f.h	PROPN
ajlm-463	148	23	.	.	PROPN
ajlm-463	148	24	oversaw	oversee	VERB
ajlm-463	148	25	the	the	DET
ajlm-463	148	26	operational	operational	ADJ
ajlm-463	148	27	aspects	aspect	NOUN
ajlm-463	148	28	of	of	ADP
ajlm-463	148	29	the	the	DET
ajlm-463	148	30	study	study	NOUN
ajlm-463	148	31	.	.	PUNCT
ajlm-463	149	1	t.c	t.c	PROPN
ajlm-463	149	2	.	.	PROPN
ajlm-463	149	3	,	,	PUNCT
ajlm-463	149	4	n.e.r	n.e.r	NOUN
ajlm-463	149	5	.	.	PUNCT
ajlm-463	150	1	and	and	CCONJ
ajlm-463	150	2	c.s	c.s	AUX
ajlm-463	150	3	.	.	PROPN
ajlm-463	150	4	conducted	conduct	VERB
ajlm-463	150	5	the	the	DET
ajlm-463	150	6	data	datum	NOUN
ajlm-463	150	7	analysis	analysis	NOUN
ajlm-463	150	8	and	and	CCONJ
ajlm-463	150	9	t.c	t.c	PROPN
ajlm-463	150	10	.	.	PROPN
ajlm-463	150	11	drafted	draft	VERB
ajlm-463	150	12	the	the	DET
ajlm-463	150	13	manuscript	manuscript	NOUN
ajlm-463	150	14	.	.	PUNCT
ajlm-463	151	1	all	all	DET
ajlm-463	151	2	authors	author	NOUN
ajlm-463	151	3	revised	revise	VERB
ajlm-463	151	4	the	the	DET
ajlm-463	151	5	manuscript	manuscript	NOUN
ajlm-463	151	6	and	and	CCONJ
ajlm-463	151	7	approved	approve	VERB
ajlm-463	151	8	the	the	DET
ajlm-463	151	9	final	final	ADJ
ajlm-463	151	10	draft	draft	NOUN
ajlm-463	151	11	.	.	PUNCT
ajlm-463	152	1	references	reference	NOUN
ajlm-463	152	2	world	world	PROPN
ajlm-463	152	3	health	health	PROPN
ajlm-463	152	4	organization	organization	NOUN
ajlm-463	152	5	.	.	PUNCT
ajlm-463	153	1	global	global	ADJ
ajlm-463	153	2	tuberculosis	tuberculosis	NOUN
ajlm-463	153	3	report	report	NOUN
ajlm-463	153	4	2015	2015	NUM
ajlm-463	153	5	.	.	PUNCT
ajlm-463	154	1	geneva	geneva	PROPN
ajlm-463	154	2	,	,	PUNCT
ajlm-463	154	3	switzerland	switzerland	PROPN
ajlm-463	154	4	:	:	PUNCT
ajlm-463	154	5	who	who	PRON
ajlm-463	154	6	;	;	PUNCT
ajlm-463	154	7	c2015	c2015	PROPN
ajlm-463	155	1	[	[	X
ajlm-463	155	2	cited	cite	VERB
ajlm-463	155	3	2016	2016	NUM
ajlm-463	155	4	jan	jan	PROPN
ajlm-463	155	5	27	27	NUM
ajlm-463	155	6	]	]	PUNCT
ajlm-463	155	7	.	.	PUNCT
ajlm-463	156	1	available	available	ADJ
ajlm-463	156	2	from	from	ADP
ajlm-463	156	3	:	:	PUNCT
ajlm-463	156	4	http://apps.who.int/iris/bitstream/10665/191102/1/9789241565059_eng.pdf	http://apps.who.int/iris/bitstream/10665/191102/1/9789241565059_eng.pdf	PROPN
ajlm-463	156	5	heep	heep	NOUN
ajlm-463	156	6	m	m	PROPN
ajlm-463	156	7	,	,	PUNCT
ajlm-463	156	8	brandstätter	brandstätter	ADJ
ajlm-463	156	9	b	b	PROPN
ajlm-463	156	10	,	,	PUNCT
ajlm-463	156	11	rieger	rieger	PROPN
ajlm-463	156	12	u	u	PROPN
ajlm-463	156	13	,	,	PUNCT
ajlm-463	156	14	et	et	PROPN
ajlm-463	156	15	al	al	PROPN
ajlm-463	156	16	.	.	PROPN
ajlm-463	156	17	frequency	frequency	PROPN
ajlm-463	156	18	of	of	ADP
ajlm-463	156	19	rpob	rpob	ADJ
ajlm-463	156	20	mutations	mutation	NOUN
ajlm-463	156	21	inside	inside	ADP
ajlm-463	156	22	and	and	CCONJ
ajlm-463	156	23	outside	outside	ADP
ajlm-463	156	24	the	the	DET
ajlm-463	156	25	cluster	cluster	NOUN
ajlm-463	156	26	i	i	PRON
ajlm-463	156	27	region	region	VERB
ajlm-463	156	28	in	in	ADP
ajlm-463	156	29	rifampin	rifampin	NOUN
ajlm-463	156	30	-	-	PUNCT
ajlm-463	156	31	resistant	resistant	ADJ
ajlm-463	156	32	clinical	clinical	ADJ
ajlm-463	156	33	mycobacterium	mycobacterium	NOUN
ajlm-463	156	34	tuberculosis	tuberculosis	NOUN
ajlm-463	156	35	isolates	isolate	NOUN
ajlm-463	156	36	.	.	PUNCT
ajlm-463	157	1	j	j	PROPN
ajlm-463	157	2	clin	clin	PROPN
ajlm-463	157	3	microbiol	microbiol	PROPN
ajlm-463	157	4	.	.	PUNCT
ajlm-463	158	1	2001;39(1):107–110	2001;39(1):107–110	PROPN
ajlm-463	158	2	.	.	PUNCT
ajlm-463	159	1	https://doi.org/10.1128/jcm.39.1.107-110.2001	https://doi.org/10.1128/jcm.39.1.107-110.2001	NOUN
ajlm-463	159	2	helb	helb	PROPN
ajlm-463	159	3	d	d	PROPN
ajlm-463	159	4	,	,	PUNCT
ajlm-463	159	5	jones	jones	PROPN
ajlm-463	159	6	m	m	PROPN
ajlm-463	159	7	,	,	PUNCT
ajlm-463	159	8	story	story	NOUN
ajlm-463	159	9	e	e	NOUN
ajlm-463	159	10	,	,	PUNCT
ajlm-463	159	11	et	et	PROPN
ajlm-463	159	12	al	al	PROPN
ajlm-463	159	13	.	.	PROPN
ajlm-463	160	1	rapid	rapid	ADJ
ajlm-463	160	2	detection	detection	NOUN
ajlm-463	160	3	of	of	ADP
ajlm-463	160	4	mycobacterium	mycobacterium	NOUN
ajlm-463	160	5	tuberculosis	tuberculosis	NOUN
ajlm-463	160	6	and	and	CCONJ
ajlm-463	160	7	rifampin	rifampin	VERB
ajlm-463	160	8	resistance	resistance	NOUN
ajlm-463	160	9	by	by	ADP
ajlm-463	160	10	use	use	NOUN
ajlm-463	160	11	of	of	ADP
ajlm-463	160	12	on	on	ADP
ajlm-463	160	13	-	-	PUNCT
ajlm-463	160	14	demand	demand	NOUN
ajlm-463	160	15	,	,	PUNCT
ajlm-463	160	16	near	near	ADP
ajlm-463	160	17	-	-	PUNCT
ajlm-463	160	18	patient	patient	NOUN
ajlm-463	160	19	technology	technology	NOUN
ajlm-463	160	20	.	.	PUNCT
ajlm-463	161	1	j	j	PROPN
ajlm-463	161	2	clin	clin	PROPN
ajlm-463	161	3	microbiol	microbiol	PROPN
ajlm-463	161	4	.	.	PUNCT
ajlm-463	162	1	2010;48(1):229–237	2010;48(1):229–237	X
ajlm-463	162	2	.	.	PUNCT
ajlm-463	163	1	https://doi.org/10.1128/jcm.01463-09	https://doi.org/10.1128/jcm.01463-09	PROPN
ajlm-463	163	2	vadwai	vadwai	PROPN
ajlm-463	163	3	v	v	NOUN
ajlm-463	163	4	,	,	PUNCT
ajlm-463	163	5	boehme	boehme	NOUN
ajlm-463	163	6	c	c	PROPN
ajlm-463	163	7	,	,	PUNCT
ajlm-463	163	8	nabeta	nabeta	ADV
ajlm-463	163	9	p	p	X
ajlm-463	163	10	,	,	PUNCT
ajlm-463	163	11	et	et	PROPN
ajlm-463	163	12	al	al	PROPN
ajlm-463	163	13	.	.	PUNCT
ajlm-463	164	1	xpert	xpert	PROPN
ajlm-463	164	2	mtb	mtb	PROPN
ajlm-463	164	3	/	/	SYM
ajlm-463	164	4	rif	rif	PROPN
ajlm-463	164	5	:	:	PUNCT
ajlm-463	164	6	a	a	DET
ajlm-463	164	7	new	new	ADJ
ajlm-463	164	8	pillar	pillar	NOUN
ajlm-463	164	9	in	in	ADP
ajlm-463	164	10	the	the	DET
ajlm-463	164	11	diagnosis	diagnosis	NOUN
ajlm-463	164	12	of	of	ADP
ajlm-463	164	13	extrapulmonary	extrapulmonary	ADJ
ajlm-463	164	14	tuberculosis	tuberculosis	NOUN
ajlm-463	164	15	?	?	PUNCT
ajlm-463	165	1	j	j	PROPN
ajlm-463	165	2	clin	clin	PROPN
ajlm-463	165	3	microbiol	microbiol	PROPN
ajlm-463	165	4	.	.	PUNCT
ajlm-463	166	1	2011;49(7):2540–5	2011;49(7):2540–5	AUX
ajlm-463	166	2	.	.	PUNCT
ajlm-463	167	1	https://doi.org/10.1128/jcm.02319-10	https://doi.org/10.1128/jcm.02319-10	PROPN
ajlm-463	167	2	van	van	PROPN
ajlm-463	167	3	rie	rie	PROPN
ajlm-463	167	4	a	a	PROPN
ajlm-463	167	5	,	,	PUNCT
ajlm-463	167	6	warren	warren	PROPN
ajlm-463	167	7	r	r	PROPN
ajlm-463	167	8	,	,	PUNCT
ajlm-463	167	9	mshanga	mshanga	PROPN
ajlm-463	167	10	i	i	PRON
ajlm-463	167	11	,	,	PUNCT
ajlm-463	167	12	et	et	PROPN
ajlm-463	167	13	al	al	PROPN
ajlm-463	167	14	.	.	PUNCT
ajlm-463	168	1	analysis	analysis	NOUN
ajlm-463	168	2	for	for	ADP
ajlm-463	168	3	a	a	DET
ajlm-463	168	4	limited	limited	ADJ
ajlm-463	168	5	number	number	NOUN
ajlm-463	168	6	of	of	ADP
ajlm-463	168	7	gene	gene	NOUN
ajlm-463	168	8	codons	codon	NOUN
ajlm-463	168	9	can	can	AUX
ajlm-463	168	10	predict	predict	VERB
ajlm-463	168	11	drug	drug	NOUN
ajlm-463	168	12	resistance	resistance	NOUN
ajlm-463	168	13	of	of	ADP
ajlm-463	168	14	mycobacterium	mycobacterium	NOUN
ajlm-463	168	15	tuberculosis	tuberculosis	NOUN
ajlm-463	168	16	in	in	ADP
ajlm-463	168	17	a	a	DET
ajlm-463	168	18	high	high	ADJ
ajlm-463	168	19	-	-	PUNCT
ajlm-463	168	20	incidence	incidence	NOUN
ajlm-463	168	21	community	community	NOUN
ajlm-463	168	22	.	.	PUNCT
ajlm-463	169	1	j	j	PROPN
ajlm-463	169	2	clin	clin	PROPN
ajlm-463	169	3	microbiol	microbiol	PROPN
ajlm-463	169	4	.	.	PUNCT
ajlm-463	170	1	2001;39(2):636–641	2001;39(2):636–641	NUM
ajlm-463	170	2	.	.	PUNCT
ajlm-463	170	3	https://doi.org/10.1128/jcm.39.2.636-641.2001	https://doi.org/10.1128/jcm.39.2.636-641.2001	VERB
ajlm-463	170	4	world	world	PROPN
ajlm-463	170	5	health	health	NOUN
ajlm-463	170	6	organization	organization	NOUN
ajlm-463	170	7	.	.	PUNCT
ajlm-463	171	1	global	global	ADJ
ajlm-463	171	2	tuberculosis	tuberculosis	NOUN
ajlm-463	171	3	report	report	NOUN
ajlm-463	171	4	2014	2014	NUM
ajlm-463	171	5	.	.	PUNCT
ajlm-463	172	1	geneva	geneva	PROPN
ajlm-463	172	2	,	,	PUNCT
ajlm-463	172	3	switzerland	switzerland	PROPN
ajlm-463	172	4	:	:	PUNCT
ajlm-463	172	5	who	who	PRON
ajlm-463	172	6	;	;	PUNCT
ajlm-463	172	7	c2014	c2014	PROPN
ajlm-463	173	1	[	[	X
ajlm-463	173	2	cited	cite	VERB
ajlm-463	173	3	2015	2015	NUM
ajlm-463	173	4	oct	oct	NOUN
ajlm-463	173	5	27	27	NUM
ajlm-463	173	6	]	]	PUNCT
ajlm-463	173	7	.	.	PUNCT
ajlm-463	174	1	available	available	ADJ
ajlm-463	174	2	from	from	ADP
ajlm-463	174	3	:	:	PUNCT
ajlm-463	174	4	http://apps.who.int/iris/bitstream/10665/137094/1/9789241564809_eng.pdf	http://apps.who.int/iris/bitstream/10665/137094/1/9789241564809_eng.pdf	PROPN
ajlm-463	174	5	chaisson	chaisson	PROPN
ajlm-463	174	6	re	re	PROPN
ajlm-463	174	7	,	,	PUNCT
ajlm-463	174	8	nuermberger	nuermberger	PROPN
ajlm-463	174	9	el	el	PROPN
ajlm-463	174	10	.	.	PUNCT
ajlm-463	175	1	confronting	confront	VERB
ajlm-463	175	2	multidrug	multidrug	NOUN
ajlm-463	175	3	-	-	PUNCT
ajlm-463	175	4	resistant	resistant	ADJ
ajlm-463	175	5	tuberculosis	tuberculosis	NOUN
ajlm-463	175	6	.	.	PUNCT
ajlm-463	176	1	n	n	PROPN
ajlm-463	176	2	engl	engl	PROPN
ajlm-463	176	3	j	j	PROPN
ajlm-463	176	4	med	med	PROPN
ajlm-463	176	5	.	.	PUNCT
ajlm-463	177	1	2012;366(23):2223–2224	2012;366(23):2223–2224	NUM
ajlm-463	177	2	.	.	X
ajlm-463	177	3	https://doi.org/10.1056/nejme1204478	https://doi.org/10.1056/nejme1204478	PROPN
ajlm-463	177	4	steingart	steingart	PROPN
ajlm-463	177	5	k	k	PROPN
ajlm-463	177	6	,	,	PUNCT
ajlm-463	177	7	schiller	schiller	PROPN
ajlm-463	177	8	i	i	PROPN
ajlm-463	177	9	,	,	PUNCT
ajlm-463	177	10	horne	horne	PROPN
ajlm-463	177	11	dj	dj	PROPN
ajlm-463	177	12	,	,	PUNCT
ajlm-463	177	13	et	et	PROPN
ajlm-463	177	14	al	al	PROPN
ajlm-463	177	15	.	.	PUNCT
ajlm-463	178	1	xpert	xpert	PROPN
ajlm-463	178	2	®	®	PROPN
ajlm-463	178	3	mtb	mtb	PROPN
ajlm-463	178	4	/	/	SYM
ajlm-463	178	5	rif	rif	PROPN
ajlm-463	178	6	assay	assay	NOUN
ajlm-463	178	7	for	for	ADP
ajlm-463	178	8	pulmonary	pulmonary	ADJ
ajlm-463	178	9	tuberculosis	tuberculosis	NOUN
ajlm-463	178	10	and	and	CCONJ
ajlm-463	178	11	rifampicin	rifampicin	VERB
ajlm-463	178	12	resistance	resistance	NOUN
ajlm-463	178	13	in	in	ADP
ajlm-463	178	14	adults	adult	NOUN
ajlm-463	178	15	.	.	PUNCT
ajlm-463	179	1	cochrane	cochrane	NOUN
ajlm-463	179	2	database	database	PROPN
ajlm-463	179	3	syst	syst	PROPN
ajlm-463	179	4	rev	rev	PROPN
ajlm-463	179	5	.	.	PROPN
ajlm-463	180	1	2014;1	2014;1	NUM
ajlm-463	180	2	:	:	PUNCT
ajlm-463	180	3	cd009593	cd009593	PROPN
ajlm-463	180	4	.	.	PUNCT
ajlm-463	181	1	https://doi.org/10.1002/14651858.cd009593.pub3	https://doi.org/10.1002/14651858.cd009593.pub3	PROPN
ajlm-463	181	2	global	global	ADJ
ajlm-463	181	3	laboratory	laboratory	PROPN
ajlm-463	181	4	initiative	initiative	NOUN
ajlm-463	181	5	.	.	PUNCT
ajlm-463	182	1	mycobacteriology	mycobacteriology	NOUN
ajlm-463	182	2	laboratory	laboratory	NOUN
ajlm-463	182	3	manual	manual	NOUN
ajlm-463	182	4	.	.	PUNCT
ajlm-463	183	1	rockville	rockville	PROPN
ajlm-463	183	2	,	,	PUNCT
ajlm-463	183	3	md	md	PROPN
ajlm-463	183	4	:	:	PUNCT
ajlm-463	183	5	otsuka	otsuka	PROPN
ajlm-463	183	6	pharmaceutical	pharmaceutical	PROPN
ajlm-463	183	7	development	development	NOUN
ajlm-463	183	8	and	and	CCONJ
ajlm-463	183	9	commercialization	commercialization	NOUN
ajlm-463	183	10	,	,	PUNCT
ajlm-463	183	11	inc	inc	PROPN
ajlm-463	183	12	.	.	PROPN
ajlm-463	183	13	;	;	PUNCT
ajlm-463	183	14	2014	2014	NUM
ajlm-463	183	15	.	.	PUNCT
ajlm-463	184	1	aung	aung	PROPN
ajlm-463	184	2	ww	ww	PROPN
ajlm-463	184	3	,	,	PUNCT
ajlm-463	184	4	ei	ei	PROPN
ajlm-463	184	5	pw	pw	PROPN
ajlm-463	184	6	,	,	PUNCT
ajlm-463	184	7	nyunt	nyunt	PROPN
ajlm-463	184	8	ww	ww	PROPN
ajlm-463	184	9	,	,	PUNCT
ajlm-463	184	10	et	et	PROPN
ajlm-463	184	11	al	al	PROPN
ajlm-463	184	12	.	.	PROPN
ajlm-463	185	1	phenotypic	phenotypic	ADJ
ajlm-463	185	2	and	and	CCONJ
ajlm-463	185	3	genotypic	genotypic	ADJ
ajlm-463	185	4	analysis	analysis	NOUN
ajlm-463	185	5	of	of	ADP
ajlm-463	185	6	anti	anti	ADJ
ajlm-463	185	7	-	-	ADJ
ajlm-463	185	8	tuberculosis	tuberculosis	ADJ
ajlm-463	185	9	drug	drug	NOUN
ajlm-463	185	10	resistance	resistance	NOUN
ajlm-463	185	11	in	in	ADP
ajlm-463	185	12	mycobacterium	mycobacterium	NOUN
ajlm-463	185	13	tuberculosis	tuberculosis	NOUN
ajlm-463	185	14	isolates	isolate	NOUN
ajlm-463	185	15	in	in	ADP
ajlm-463	185	16	myanmar	myanmar	PROPN
ajlm-463	185	17	.	.	PUNCT
ajlm-463	186	1	ann	ann	PROPN
ajlm-463	186	2	lab	lab	PROPN
ajlm-463	186	3	med	med	PROPN
ajlm-463	186	4	.	.	PUNCT
ajlm-463	187	1	2015;35(5):494–499	2015;35(5):494–499	X
ajlm-463	187	2	.	.	PUNCT
ajlm-463	188	1	https://doi.org/10.3343/alm.2015.35.5.494	https://doi.org/10.3343/alm.2015.35.5.494	PROPN
ajlm-463	188	2	musser	musser	PROPN
ajlm-463	188	3	jm	jm	PROPN
ajlm-463	188	4	.	.	PROPN
ajlm-463	188	5	antimicrobial	antimicrobial	ADJ
ajlm-463	188	6	agent	agent	NOUN
ajlm-463	188	7	resistance	resistance	NOUN
ajlm-463	188	8	in	in	ADP
ajlm-463	188	9	mycobacteria	mycobacteria	NOUN
ajlm-463	188	10	:	:	PUNCT
ajlm-463	188	11	molecular	molecular	ADJ
ajlm-463	188	12	genetic	genetic	ADJ
ajlm-463	188	13	insights	insight	NOUN
ajlm-463	188	14	.	.	PUNCT
ajlm-463	189	1	clin	clin	PROPN
ajlm-463	189	2	microbiol	microbiol	PROPN
ajlm-463	189	3	rev	rev	VERB
ajlm-463	189	4	.	.	PROPN
ajlm-463	190	1	1995;8(4):496–514	1995;8(4):496–514	X
ajlm-463	190	2	.	.	X
ajlm-463	190	3	rattan	rattan	ADJ
ajlm-463	190	4	a	a	PRON
ajlm-463	190	5	,	,	PUNCT
ajlm-463	190	6	kalia	kalia	PROPN
ajlm-463	190	7	a	a	X
ajlm-463	190	8	,	,	PUNCT
ajlm-463	190	9	ahmad	ahmad	PROPN
ajlm-463	190	10	n.	n.	PROPN
ajlm-463	190	11	multidrug	multidrug	NOUN
ajlm-463	190	12	-	-	PUNCT
ajlm-463	190	13	resistant	resistant	ADJ
ajlm-463	190	14	mycobacterium	mycobacterium	NOUN
ajlm-463	190	15	tuberculosis	tuberculosis	NOUN
ajlm-463	190	16	:	:	PUNCT
ajlm-463	190	17	molecular	molecular	ADJ
ajlm-463	190	18	perspectives	perspective	NOUN
ajlm-463	190	19	.	.	PUNCT
ajlm-463	191	1	emerg	emerg	VERB
ajlm-463	191	2	infect	infect	ADJ
ajlm-463	191	3	dis	dis	PROPN
ajlm-463	191	4	.	.	PUNCT
ajlm-463	192	1	1998;4(2):195–209	1998;4(2):195–209	X
ajlm-463	192	2	.	.	PUNCT
ajlm-463	193	1	https://doi.org/10.3201/eid0402.980207	https://doi.org/10.3201/eid0402.980207	PROPN
ajlm-463	193	2	nettleman	nettleman	PROPN
ajlm-463	193	3	md	md	PROPN
ajlm-463	193	4	.	.	PROPN
ajlm-463	193	5	multidrug	multidrug	NOUN
ajlm-463	193	6	-	-	PUNCT
ajlm-463	193	7	resistant	resistant	ADJ
ajlm-463	193	8	tuberculosis	tuberculosis	NOUN
ajlm-463	193	9	:	:	PUNCT
ajlm-463	193	10	news	news	NOUN
ajlm-463	193	11	from	from	ADP
ajlm-463	193	12	the	the	DET
ajlm-463	193	13	front	front	NOUN
ajlm-463	193	14	.	.	PUNCT
ajlm-463	194	1	jama	jama	PROPN
ajlm-463	194	2	.	.	PUNCT
ajlm-463	195	1	2005;293(22):2788–2790	2005;293(22):2788–2790	NUM
ajlm-463	195	2	.	.	PUNCT
ajlm-463	196	1	https://doi.org/10.1001/jama.293.22.2788	https://doi.org/10.1001/jama.293.22.2788	PROPN
ajlm-463	196	2	world	world	NOUN
ajlm-463	196	3	health	health	NOUN
ajlm-463	196	4	organization	organization	NOUN
ajlm-463	196	5	.	.	PUNCT
ajlm-463	197	1	global	global	ADJ
ajlm-463	197	2	tuberculosis	tuberculosis	NOUN
ajlm-463	197	3	control	control	NOUN
ajlm-463	197	4	2008	2008	NUM
ajlm-463	197	5	:	:	PUNCT
ajlm-463	197	6	surveillance	surveillance	NOUN
ajlm-463	197	7	,	,	PUNCT
ajlm-463	197	8	planning	planning	NOUN
ajlm-463	197	9	,	,	PUNCT
ajlm-463	197	10	financing	financing	NOUN
ajlm-463	197	11	.	.	PUNCT
ajlm-463	198	1	geneva	geneva	PROPN
ajlm-463	198	2	,	,	PUNCT
ajlm-463	198	3	switzerland	switzerland	PROPN
ajlm-463	198	4	:	:	PUNCT
ajlm-463	198	5	who	who	PRON
ajlm-463	198	6	;	;	PUNCT
ajlm-463	198	7	c2008	c2008	PROPN
ajlm-463	199	1	[	[	X
ajlm-463	199	2	cited	cite	VERB
ajlm-463	199	3	2016	2016	NUM
ajlm-463	199	4	nov	nov	NOUN
ajlm-463	199	5	06	06	NUM
ajlm-463	199	6	]	]	PUNCT
ajlm-463	199	7	.	.	PUNCT
ajlm-463	200	1	available	available	ADJ
ajlm-463	200	2	from	from	ADP
ajlm-463	200	3	:	:	PUNCT
ajlm-463	200	4	http://data.unaids.org/pub/report/2008/who2008globaltbreport_en.pdf	http://data.unaids.org/pub/report/2008/who2008globaltbreport_en.pdf	PROPN
ajlm-463	200	5	garcía	garcía	PROPN
ajlm-463	200	6	de	de	PROPN
ajlm-463	200	7	viedma	viedma	PROPN
ajlm-463	200	8	d.	d.	PROPN
ajlm-463	200	9	rapid	rapid	ADJ
ajlm-463	200	10	detection	detection	NOUN
ajlm-463	200	11	of	of	ADP
ajlm-463	200	12	resistance	resistance	NOUN
ajlm-463	200	13	in	in	ADP
ajlm-463	200	14	mycobacterium	mycobacterium	NOUN
ajlm-463	200	15	tuberculosis	tuberculosis	NOUN
ajlm-463	200	16	:	:	PUNCT
ajlm-463	200	17	a	a	DET
ajlm-463	200	18	review	review	NOUN
ajlm-463	200	19	discussing	discuss	VERB
ajlm-463	200	20	molecular	molecular	ADJ
ajlm-463	200	21	approaches	approach	NOUN
ajlm-463	200	22	.	.	PUNCT
ajlm-463	201	1	clin	clin	PROPN
ajlm-463	201	2	microbiol	microbiol	PROPN
ajlm-463	201	3	infect	infect	PROPN
ajlm-463	201	4	.	.	PUNCT
ajlm-463	202	1	2003;9(5):349–359	2003;9(5):349–359	X
ajlm-463	202	2	.	.	PUNCT
ajlm-463	203	1	cepheid	cepheid	PROPN
ajlm-463	203	2	.	.	PUNCT
ajlm-463	204	1	xpert	xpert	PROPN
ajlm-463	204	2	®	®	PROPN
ajlm-463	204	3	mtb	mtb	PROPN
ajlm-463	204	4	/	/	SYM
ajlm-463	204	5	rif	rif	PROPN
ajlm-463	204	6	two	two	NUM
ajlm-463	204	7	-	-	PUNCT
ajlm-463	204	8	hour	hour	NOUN
ajlm-463	204	9	detection	detection	NOUN
ajlm-463	204	10	of	of	ADP
ajlm-463	204	11	mtb	mtb	NOUN
ajlm-463	204	12	and	and	CCONJ
ajlm-463	204	13	resistance	resistance	NOUN
ajlm-463	204	14	to	to	ADP
ajlm-463	204	15	rifampicin	rifampicin	VERB
ajlm-463	204	16	.	.	PUNCT
ajlm-463	205	1	sunnyvale	sunnyvale	PROPN
ajlm-463	205	2	,	,	PUNCT
ajlm-463	205	3	ca	ca	NOUN
ajlm-463	205	4	:	:	PUNCT
ajlm-463	205	5	cepheid	cepheid	NOUN
ajlm-463	205	6	;	;	PUNCT
ajlm-463	205	7	c2011	c2011	PROPN
ajlm-463	206	1	[	[	X
ajlm-463	206	2	cited	cite	VERB
ajlm-463	206	3	2011	2011	NUM
ajlm-463	206	4	nov	nov	NOUN
ajlm-463	206	5	07	07	NUM
ajlm-463	206	6	]	]	PUNCT
ajlm-463	206	7	.	.	PUNCT
ajlm-463	207	1	available	available	ADJ
ajlm-463	207	2	form	form	NOUN
ajlm-463	207	3	http://xpert_mtbrif	http://xpert_mtbrif	PUNCT
ajlm-463	207	4	brochure	brochure	NOUN
ajlm-463	207	5	eu	eu	PROPN
ajlm-463	207	6	0089-02lor.pdf	0089-02lor.pdf	PROPN
ajlm-463	207	7	bowles	bowles	PROPN
ajlm-463	207	8	ec	ec	PROPN
ajlm-463	207	9	,	,	PUNCT
ajlm-463	207	10	freyée	freyée	PROPN
ajlm-463	207	11	b	b	PROPN
ajlm-463	207	12	,	,	PUNCT
ajlm-463	207	13	van	van	PROPN
ajlm-463	207	14	ingen	ingen	PROPN
ajlm-463	207	15	j	j	PROPN
ajlm-463	207	16	,	,	PUNCT
ajlm-463	207	17	et	et	PROPN
ajlm-463	207	18	al	al	PROPN
ajlm-463	207	19	.	.	PUNCT
ajlm-463	208	1	xpert	xpert	PROPN
ajlm-463	208	2	mtb	mtb	PROPN
ajlm-463	208	3	/	/	SYM
ajlm-463	208	4	rif	rif	PROPN
ajlm-463	208	5	®	®	PROPN
ajlm-463	208	6	,	,	PUNCT
ajlm-463	208	7	a	a	DET
ajlm-463	208	8	novel	novel	ADJ
ajlm-463	208	9	automated	automate	VERB
ajlm-463	208	10	polymerase	polymerase	NOUN
ajlm-463	208	11	chain	chain	NOUN
ajlm-463	208	12	reaction	reaction	NOUN
ajlm-463	208	13	-	-	PUNCT
ajlm-463	208	14	based	base	VERB
ajlm-463	208	15	tool	tool	NOUN
ajlm-463	208	16	for	for	ADP
ajlm-463	208	17	the	the	DET
ajlm-463	208	18	diagnosis	diagnosis	NOUN
ajlm-463	208	19	of	of	ADP
ajlm-463	208	20	tuberculosis	tuberculosis	NOUN
ajlm-463	208	21	.	.	PUNCT
ajlm-463	209	1	int	int	PROPN
ajlm-463	209	2	j	j	PROPN
ajlm-463	209	3	tuberc	tuberc	PROPN
ajlm-463	209	4	lung	lung	PROPN
ajlm-463	209	5	dis	dis	PROPN
ajlm-463	209	6	.	.	PUNCT
ajlm-463	210	1	2011;15(7):988–989	2011;15(7):988–989	NUM
ajlm-463	210	2	.	.	PUNCT
ajlm-463	211	1	https://doi.org/10.5588/ijtld.10.0574	https://doi.org/10.5588/ijtld.10.0574	PROPN
ajlm-463	211	2	kourout	kourout	PROPN
ajlm-463	211	3	m	m	PROPN
ajlm-463	211	4	,	,	PUNCT
ajlm-463	211	5	chaoui	chaoui	PROPN
ajlm-463	211	6	i	i	PRON
ajlm-463	211	7	,	,	PUNCT
ajlm-463	211	8	sabouni	sabouni	NOUN
ajlm-463	211	9	r	r	NOUN
ajlm-463	211	10	,	,	PUNCT
ajlm-463	211	11	et	et	PROPN
ajlm-463	211	12	al	al	PROPN
ajlm-463	211	13	.	.	PUNCT
ajlm-463	212	1	molecular	molecular	ADJ
ajlm-463	212	2	characterisation	characterisation	NOUN
ajlm-463	212	3	of	of	ADP
ajlm-463	212	4	rifampicin	rifampicin	VERB
ajlm-463	212	5	-	-	PUNCT
ajlm-463	212	6	resistant	resistant	ADJ
ajlm-463	212	7	mycobacterium	mycobacterium	NOUN
ajlm-463	212	8	tuberculosis	tuberculosis	NOUN
ajlm-463	212	9	strains	strain	NOUN
ajlm-463	212	10	from	from	ADP
ajlm-463	212	11	morocco	morocco	PROPN
ajlm-463	212	12	.	.	PUNCT
ajlm-463	213	1	int	int	PROPN
ajlm-463	213	2	j	j	PROPN
ajlm-463	213	3	tuberc	tuberc	PROPN
ajlm-463	213	4	lung	lung	PROPN
ajlm-463	213	5	dis	dis	PROPN
ajlm-463	213	6	.	.	PUNCT
ajlm-463	214	1	2009;13(11):1440–1442	2009;13(11):1440–1442	X
ajlm-463	214	2	.	.	PUNCT
ajlm-463	215	1	choi	choi	PROPN
ajlm-463	215	2	j	j	PROPN
ajlm-463	215	3	-	-	PROPN
ajlm-463	215	4	h	h	PROPN
ajlm-463	215	5	,	,	PUNCT
ajlm-463	215	6	lee	lee	PROPN
ajlm-463	215	7	kw	kw	PROPN
ajlm-463	215	8	,	,	PUNCT
ajlm-463	215	9	kang	kang	PROPN
ajlm-463	215	10	h	h	PROPN
ajlm-463	215	11	-	-	PUNCT
ajlm-463	215	12	r	r	NOUN
ajlm-463	215	13	,	,	PUNCT
ajlm-463	215	14	et	et	PROPN
ajlm-463	215	15	al	al	PROPN
ajlm-463	215	16	.	.	PROPN
ajlm-463	216	1	clinical	clinical	ADJ
ajlm-463	216	2	efficacy	efficacy	NOUN
ajlm-463	216	3	of	of	ADP
ajlm-463	216	4	direct	direct	ADJ
ajlm-463	216	5	dna	dna	NOUN
ajlm-463	216	6	sequencing	sequence	VERB
ajlm-463	216	7	analysis	analysis	NOUN
ajlm-463	216	8	on	on	ADP
ajlm-463	216	9	sputum	sputum	NOUN
ajlm-463	216	10	specimens	specimen	NOUN
ajlm-463	216	11	for	for	ADP
ajlm-463	216	12	early	early	ADJ
ajlm-463	216	13	detection	detection	NOUN
ajlm-463	216	14	of	of	ADP
ajlm-463	216	15	drug	drug	NOUN
ajlm-463	216	16	-	-	PUNCT
ajlm-463	216	17	resistant	resistant	ADJ
ajlm-463	216	18	mycobacterium	mycobacterium	NOUN
ajlm-463	216	19	tuberculosis	tuberculosis	NOUN
ajlm-463	216	20	in	in	ADP
ajlm-463	216	21	a	a	DET
ajlm-463	216	22	clinical	clinical	ADJ
ajlm-463	216	23	setting	setting	NOUN
ajlm-463	216	24	.	.	PUNCT
ajlm-463	217	1	chest	chest	NOUN
ajlm-463	217	2	.	.	PUNCT
ajlm-463	218	1	2010;137(2):393–400	2010;137(2):393–400	X
ajlm-463	218	2	.	.	PUNCT
ajlm-463	219	1	https://doi.org/10.1378/chest.09-0150	https://doi.org/10.1378/chest.09-0150	PROPN
ajlm-463	219	2	xiao	xiao	PROPN
ajlm-463	219	3	hp	hp	PROPN
ajlm-463	219	4	.	.	PROPN
ajlm-463	219	5	progress	progress	NOUN
ajlm-463	219	6	in	in	ADP
ajlm-463	219	7	tuberculosis	tuberculosis	NOUN
ajlm-463	219	8	control	control	NOUN
ajlm-463	219	9	.	.	PUNCT
ajlm-463	220	1	shanghai	shanghai	PROPN
ajlm-463	220	2	,	,	PUNCT
ajlm-463	220	3	china	china	PROPN
ajlm-463	220	4	:	:	PUNCT
ajlm-463	220	5	fudan	fudan	PROPN
ajlm-463	220	6	university	university	NOUN
ajlm-463	220	7	press	press	NOUN
ajlm-463	220	8	;	;	PUNCT
ajlm-463	220	9	c2004	c2004	PROPN
ajlm-463	220	10	[	[	X
ajlm-463	220	11	cited	cite	VERB
ajlm-463	220	12	2011	2011	NUM
ajlm-463	220	13	nov	nov	NOUN
ajlm-463	220	14	07	07	NUM
ajlm-463	220	15	]	]	PUNCT
ajlm-463	220	16	.	.	PUNCT
ajlm-463	221	1	available	available	ADJ
ajlm-463	221	2	from	from	ADP
ajlm-463	221	3	:	:	PUNCT
ajlm-463	221	4	http://xpert_mtbrif	http://xpert_mtbrif	X
ajlm-463	221	5	brochure	brochure	NOUN
ajlm-463	221	6	eu	eu	PROPN
ajlm-463	221	7	0089-02lor.pdf	0089-02lor.pdf	PROPN
ajlm-463	221	8	si	si	PROPN
ajlm-463	221	9	j	j	PROPN
ajlm-463	221	10	,	,	PUNCT
ajlm-463	221	11	wang	wang	PROPN
ajlm-463	221	12	z	z	PROPN
ajlm-463	221	13	,	,	PUNCT
ajlm-463	221	14	wang	wang	PROPN
ajlm-463	221	15	z	z	PROPN
ajlm-463	221	16	,	,	PUNCT
ajlm-463	221	17	et	et	PROPN
ajlm-463	221	18	al	al	PROPN
ajlm-463	221	19	.	.	PUNCT
ajlm-463	222	1	sequencing	sequence	VERB
ajlm-463	222	2	-	-	PUNCT
ajlm-463	222	3	based	base	VERB
ajlm-463	222	4	detection	detection	NOUN
ajlm-463	222	5	of	of	ADP
ajlm-463	222	6	drug	drug	NOUN
ajlm-463	222	7	-	-	PUNCT
ajlm-463	222	8	resistant	resistant	ADJ
ajlm-463	222	9	mycobacterium	mycobacterium	NOUN
ajlm-463	222	10	tuberculosis	tuberculosis	NOUN
ajlm-463	222	11	in	in	ADP
ajlm-463	222	12	patients	patient	NOUN
ajlm-463	222	13	with	with	ADP
ajlm-463	222	14	spinal	spinal	ADJ
ajlm-463	222	15	tuberculosis	tuberculosis	NOUN
ajlm-463	222	16	.	.	PUNCT
ajlm-463	223	1	arch	arch	ADJ
ajlm-463	223	2	orthop	orthop	NOUN
ajlm-463	223	3	trauma	trauma	NOUN
ajlm-463	223	4	surg	surg	NOUN
ajlm-463	223	5	.	.	PUNCT
ajlm-463	224	1	2012	2012	NUM
ajlm-463	225	1	jul;132(7):941–945	jul;132(7):941–945	PROPN
ajlm-463	225	2	.	.	PUNCT
ajlm-463	226	1	https://doi.org/10.1007/s00402-012-1506-7	https://doi.org/10.1007/s00402-012-1506-7	PROPN
ajlm-463	226	2	barnett	barnett	PROPN
ajlm-463	226	3	b	b	PROPN
ajlm-463	226	4	,	,	PUNCT
ajlm-463	226	5	gokhale	gokhale	PROPN
ajlm-463	226	6	rh	rh	PROPN
ajlm-463	226	7	,	,	PUNCT
ajlm-463	226	8	krysiak	krysiak	PROPN
ajlm-463	226	9	r	r	PROPN
ajlm-463	226	10	,	,	PUNCT
ajlm-463	226	11	et	et	PROPN
ajlm-463	226	12	al	al	PROPN
ajlm-463	226	13	.	.	PUNCT
ajlm-463	227	1	prevalence	prevalence	NOUN
ajlm-463	227	2	of	of	ADP
ajlm-463	227	3	drug	drug	NOUN
ajlm-463	227	4	resistant	resistant	ADJ
ajlm-463	227	5	tb	tb	ADP
ajlm-463	227	6	among	among	ADP
ajlm-463	227	7	outpatients	outpatient	NOUN
ajlm-463	227	8	at	at	ADP
ajlm-463	227	9	an	an	DET
ajlm-463	227	10	hiv	hiv	PROPN
ajlm-463	227	11	/	/	SYM
ajlm-463	227	12	tb	tb	NOUN
ajlm-463	227	13	clinic	clinic	NOUN
ajlm-463	227	14	in	in	ADP
ajlm-463	227	15	lilongwe	lilongwe	PROPN
ajlm-463	227	16	,	,	PUNCT
ajlm-463	227	17	malawi	malawi	PROPN
ajlm-463	227	18	.	.	PUNCT
ajlm-463	228	1	trans	trans	PROPN
ajlm-463	228	2	r	r	PROPN
ajlm-463	228	3	soc	soc	PROPN
ajlm-463	228	4	trop	trop	X
ajlm-463	228	5	med	med	PROPN
ajlm-463	228	6	hyg	hyg	PROPN
ajlm-463	228	7	.	.	PUNCT
ajlm-463	229	1	2015;109(12):763–768	2015;109(12):763–768	NUM
ajlm-463	229	2	.	.	PUNCT
ajlm-463	229	3	https://doi.org/10.1093/trstmh/trv092	https://doi.org/10.1093/trstmh/trv092	PROPN
ajlm-463	229	4	blakemore	blakemore	VERB
ajlm-463	229	5	r	r	NOUN
ajlm-463	229	6	,	,	PUNCT
ajlm-463	229	7	nabeta	nabeta	ADV
ajlm-463	229	8	p	p	NOUN
ajlm-463	229	9	,	,	PUNCT
ajlm-463	229	10	davidow	davidow	PROPN
ajlm-463	229	11	al	al	PROPN
ajlm-463	229	12	,	,	PUNCT
ajlm-463	229	13	et	et	PROPN
ajlm-463	229	14	al	al	PROPN
ajlm-463	229	15	.	.	PUNCT
ajlm-463	230	1	a	a	DET
ajlm-463	230	2	multi	multi	ADJ
ajlm-463	230	3	-	-	ADJ
ajlm-463	230	4	site	site	ADJ
ajlm-463	230	5	assessment	assessment	NOUN
ajlm-463	230	6	of	of	ADP
ajlm-463	230	7	the	the	DET
ajlm-463	230	8	quantitative	quantitative	ADJ
ajlm-463	230	9	capability	capability	NOUN
ajlm-463	230	10	of	of	ADP
ajlm-463	230	11	the	the	DET
ajlm-463	230	12	xpert	xpert	PROPN
ajlm-463	230	13	mtb	mtb	PROPN
ajlm-463	230	14	/	/	SYM
ajlm-463	230	15	rif	rif	PROPN
ajlm-463	230	16	assay	assay	PROPN
ajlm-463	230	17	.	.	PUNCT
ajlm-463	231	1	am	be	AUX
ajlm-463	231	2	j	j	PROPN
ajlm-463	231	3	respir	respir	NOUN
ajlm-463	231	4	crit	crit	PROPN
ajlm-463	231	5	care	care	NOUN
ajlm-463	231	6	med	me	VERB
ajlm-463	231	7	.	.	PUNCT
ajlm-463	232	1	2011;184(9):1076–1084	2011;184(9):1076–1084	NUM
ajlm-463	232	2	.	.	PUNCT
ajlm-463	233	1	https://doi.org/10.1164/rccm.201103-0536oc	https://doi.org/10.1164/rccm.201103-0536oc	PROPN
ajlm-463	233	2	nicol	nicol	PROPN
ajlm-463	233	3	mp	mp	PROPN
ajlm-463	233	4	,	,	PUNCT
ajlm-463	233	5	workman	workman	NOUN
ajlm-463	233	6	l	l	PROPN
ajlm-463	233	7	,	,	PUNCT
ajlm-463	233	8	isaacs	isaacs	PROPN
ajlm-463	233	9	w	w	PROPN
ajlm-463	233	10	,	,	PUNCT
ajlm-463	233	11	et	et	PROPN
ajlm-463	233	12	al	al	PROPN
ajlm-463	233	13	.	.	PROPN
ajlm-463	233	14	accuracy	accuracy	NOUN
ajlm-463	233	15	of	of	ADP
ajlm-463	233	16	the	the	DET
ajlm-463	233	17	xpert	xpert	PROPN
ajlm-463	233	18	mtb	mtb	PROPN
ajlm-463	233	19	/	/	SYM
ajlm-463	233	20	rif	rif	PROPN
ajlm-463	233	21	test	test	NOUN
ajlm-463	233	22	for	for	ADP
ajlm-463	233	23	the	the	DET
ajlm-463	233	24	diagnosis	diagnosis	NOUN
ajlm-463	233	25	of	of	ADP
ajlm-463	233	26	pulmonary	pulmonary	ADJ
ajlm-463	233	27	tuberculosis	tuberculosis	NOUN
ajlm-463	233	28	in	in	ADP
ajlm-463	233	29	children	child	NOUN
ajlm-463	233	30	admitted	admit	VERB
ajlm-463	233	31	to	to	ADP
ajlm-463	233	32	hospital	hospital	NOUN
ajlm-463	233	33	in	in	ADP
ajlm-463	233	34	cape	cape	NOUN
ajlm-463	233	35	town	town	NOUN
ajlm-463	233	36	,	,	PUNCT
ajlm-463	233	37	south	south	PROPN
ajlm-463	233	38	africa	africa	PROPN
ajlm-463	233	39	:	:	PUNCT
ajlm-463	233	40	a	a	DET
ajlm-463	233	41	descriptive	descriptive	ADJ
ajlm-463	233	42	study	study	NOUN
ajlm-463	233	43	.	.	PUNCT
ajlm-463	234	1	lancet	lancet	PROPN
ajlm-463	234	2	infect	infect	PROPN
ajlm-463	234	3	dis	dis	PROPN
ajlm-463	234	4	.	.	PUNCT
ajlm-463	235	1	2011;11(11):819–824	2011;11(11):819–824	X
ajlm-463	235	2	.	.	PUNCT
ajlm-463	236	1	https://doi.org/10.1016/s1473-3099(11)70167-0	https://doi.org/10.1016/s1473-3099(11)70167-0	PROPN
ajlm-463	236	2	scott	scott	PROPN
ajlm-463	236	3	le	le	PROPN
ajlm-463	236	4	,	,	PUNCT
ajlm-463	236	5	mccarthy	mccarthy	PROPN
ajlm-463	236	6	k	k	PROPN
ajlm-463	236	7	,	,	PUNCT
ajlm-463	236	8	gous	gous	ADJ
ajlm-463	236	9	n	n	CCONJ
ajlm-463	236	10	,	,	PUNCT
ajlm-463	236	11	et	et	PROPN
ajlm-463	236	12	al	al	PROPN
ajlm-463	236	13	.	.	PROPN
ajlm-463	236	14	comparison	comparison	NOUN
ajlm-463	236	15	of	of	ADP
ajlm-463	236	16	xpert	xpert	PROPN
ajlm-463	236	17	mtb	mtb	PROPN
ajlm-463	236	18	/	/	SYM
ajlm-463	236	19	rif	rif	PROPN
ajlm-463	236	20	with	with	ADP
ajlm-463	236	21	other	other	ADJ
ajlm-463	236	22	nucleic	nucleic	ADJ
ajlm-463	236	23	acid	acid	NOUN
ajlm-463	236	24	technologies	technology	NOUN
ajlm-463	236	25	for	for	ADP
ajlm-463	236	26	diagnosing	diagnose	VERB
ajlm-463	236	27	pulmonary	pulmonary	ADJ
ajlm-463	236	28	tuberculosis	tuberculosis	NOUN
ajlm-463	236	29	in	in	ADP
ajlm-463	236	30	a	a	DET
ajlm-463	236	31	high	high	ADJ
ajlm-463	236	32	hiv	hiv	PROPN
ajlm-463	236	33	prevalence	prevalence	NOUN
ajlm-463	236	34	setting	set	VERB
ajlm-463	236	35	:	:	PUNCT
ajlm-463	236	36	a	a	DET
ajlm-463	236	37	prospective	prospective	ADJ
ajlm-463	236	38	study	study	NOUN
ajlm-463	236	39	.	.	PUNCT
ajlm-463	237	1	plos	plos	PROPN
ajlm-463	237	2	med	med	PROPN
ajlm-463	237	3	.	.	PUNCT
ajlm-463	238	1	2011;8(7):1–11	2011;8(7):1–11	X
ajlm-463	238	2	.	.	PUNCT
ajlm-463	239	1	https://doi.org/10.1371/journal.pmed.1001061	https://doi.org/10.1371/journal.pmed.1001061	PROPN
ajlm-463	239	2	ohno	ohno	PROPN
ajlm-463	239	3	h	h	PROPN
ajlm-463	239	4	,	,	PUNCT
ajlm-463	239	5	koga	koga	PROPN
ajlm-463	239	6	h	h	PROPN
ajlm-463	239	7	,	,	PUNCT
ajlm-463	239	8	kohno	kohno	PROPN
ajlm-463	239	9	s	s	PROPN
ajlm-463	239	10	,	,	PUNCT
ajlm-463	239	11	et	et	PROPN
ajlm-463	239	12	al	al	PROPN
ajlm-463	239	13	.	.	PROPN
ajlm-463	239	14	relationship	relationship	NOUN
ajlm-463	239	15	between	between	ADP
ajlm-463	239	16	rifampin	rifampin	NOUN
ajlm-463	239	17	mics	mic	NOUN
ajlm-463	239	18	for	for	ADP
ajlm-463	239	19	and	and	CCONJ
ajlm-463	239	20	rpob	rpob	ADJ
ajlm-463	239	21	mutations	mutation	NOUN
ajlm-463	239	22	of	of	ADP
ajlm-463	239	23	mycobacterium	mycobacterium	NOUN
ajlm-463	239	24	tuberculosis	tuberculosis	NOUN
ajlm-463	239	25	strains	strain	NOUN
ajlm-463	239	26	isolated	isolate	VERB
ajlm-463	239	27	in	in	ADP
ajlm-463	239	28	japan	japan	PROPN
ajlm-463	239	29	.	.	PUNCT
ajlm-463	240	1	antimicrob	antimicrob	PROPN
ajlm-463	240	2	agents	agents	PROPN
ajlm-463	240	3	chemother	chemother	PROPN
ajlm-463	240	4	.	.	PUNCT
ajlm-463	241	1	1996;40(4):1053–1056	1996;40(4):1053–1056	NUM
ajlm-463	241	2	.	.	PUNCT
ajlm-463	242	1	madania	madania	PROPN
ajlm-463	242	2	a	a	DET
ajlm-463	242	3	,	,	PUNCT
ajlm-463	242	4	habous	habous	ADJ
ajlm-463	242	5	m	m	NOUN
ajlm-463	242	6	,	,	PUNCT
ajlm-463	242	7	zarzour	zarzour	PROPN
ajlm-463	242	8	h	h	NOUN
ajlm-463	242	9	,	,	PUNCT
ajlm-463	242	10	et	et	PROPN
ajlm-463	242	11	al	al	PROPN
ajlm-463	242	12	.	.	PUNCT
ajlm-463	242	13	characterization	characterization	NOUN
ajlm-463	242	14	of	of	ADP
ajlm-463	242	15	mutations	mutation	NOUN
ajlm-463	242	16	causing	cause	VERB
ajlm-463	242	17	rifampicin	rifampicin	VERB
ajlm-463	242	18	and	and	CCONJ
ajlm-463	242	19	isoniazid	isoniazid	NOUN
ajlm-463	242	20	resistance	resistance	NOUN
ajlm-463	242	21	of	of	ADP
ajlm-463	242	22	mycobacterium	mycobacterium	NOUN
ajlm-463	242	23	tuberculosis	tuberculosis	NOUN
ajlm-463	242	24	in	in	ADP
ajlm-463	242	25	syria	syria	PROPN
ajlm-463	242	26	.	.	PUNCT
ajlm-463	243	1	polish	polish	PROPN
ajlm-463	243	2	j	j	PROPN
ajlm-463	243	3	microbiol	microbiol	PROPN
ajlm-463	243	4	.	.	PUNCT
ajlm-463	244	1	2012;61(1):23–32	2012;61(1):23–32	X
ajlm-463	244	2	.	.	PUNCT
ajlm-463	244	3	ramaswamy	ramaswamy	PROPN
ajlm-463	244	4	s	s	PROPN
ajlm-463	244	5	,	,	PUNCT
ajlm-463	244	6	musser	musser	PROPN
ajlm-463	244	7	jm	jm	PROPN
ajlm-463	244	8	.	.	PROPN
ajlm-463	245	1	molecular	molecular	ADJ
ajlm-463	245	2	genetic	genetic	ADJ
ajlm-463	245	3	basis	basis	NOUN
ajlm-463	245	4	of	of	ADP
ajlm-463	245	5	antimicrobial	antimicrobial	ADJ
ajlm-463	245	6	agent	agent	NOUN
ajlm-463	245	7	resistance	resistance	NOUN
ajlm-463	245	8	in	in	ADP
ajlm-463	245	9	mycobacterium	mycobacterium	NOUN
ajlm-463	245	10	tuberculosis	tuberculosis	NOUN
ajlm-463	245	11	:	:	PUNCT
ajlm-463	245	12	1998	1998	NUM
ajlm-463	245	13	update	update	NOUN
ajlm-463	245	14	.	.	PUNCT
ajlm-463	246	1	tuber	tuber	PROPN
ajlm-463	246	2	lung	lung	PROPN
ajlm-463	246	3	dis	dis	PROPN
ajlm-463	246	4	.	.	PUNCT
ajlm-463	247	1	1998;79(1):3–29	1998;79(1):3–29	PROPN
ajlm-463	247	2	.	.	PUNCT
ajlm-463	248	1	https://doi.org/10.1054/tuld.1998.0002	https://doi.org/10.1054/tuld.1998.0002	PROPN
ajlm-463	248	2	mani	mani	PROPN
ajlm-463	248	3	c	c	PROPN
ajlm-463	248	4	,	,	PUNCT
ajlm-463	248	5	selvakumar	selvakumar	PROPN
ajlm-463	248	6	n	n	PROPN
ajlm-463	248	7	,	,	PUNCT
ajlm-463	248	8	narayanan	narayanan	PROPN
ajlm-463	248	9	s	s	PROPN
ajlm-463	248	10	,	,	PUNCT
ajlm-463	248	11	et	et	PROPN
ajlm-463	248	12	al	al	PROPN
ajlm-463	248	13	.	.	PUNCT
ajlm-463	248	14	mutations	mutation	NOUN
ajlm-463	248	15	in	in	ADP
ajlm-463	248	16	the	the	DET
ajlm-463	248	17	rpob	rpob	ADJ
ajlm-463	248	18	gene	gene	NOUN
ajlm-463	248	19	of	of	ADP
ajlm-463	248	20	multidrug	multidrug	NOUN
ajlm-463	248	21	-	-	PUNCT
ajlm-463	248	22	resistant	resistant	ADJ
ajlm-463	248	23	mycobacterium	mycobacterium	NOUN
ajlm-463	248	24	tuberculosis	tuberculosis	NOUN
ajlm-463	248	25	clinical	clinical	ADJ
ajlm-463	248	26	isolates	isolate	NOUN
ajlm-463	248	27	from	from	ADP
ajlm-463	248	28	india	india	PROPN
ajlm-463	248	29	.	.	PUNCT
ajlm-463	249	1	j	j	PROPN
ajlm-463	249	2	clin	clin	PROPN
ajlm-463	249	3	microbiol	microbiol	PROPN
ajlm-463	249	4	.	.	PUNCT
ajlm-463	250	1	2001;39(8):2987–2990	2001;39(8):2987–2990	NUM
ajlm-463	250	2	.	.	PUNCT
ajlm-463	251	1	https://doi.org/10.1128/jcm.39.8.2987-2990.2001	https://doi.org/10.1128/jcm.39.8.2987-2990.2001	NOUN
ajlm-463	251	2	siddiqi	siddiqi	PROPN
ajlm-463	251	3	n	n	CCONJ
ajlm-463	251	4	,	,	PUNCT
ajlm-463	251	5	shamim	shamim	PROPN
ajlm-463	251	6	m	m	PROPN
ajlm-463	251	7	,	,	PUNCT
ajlm-463	251	8	hussain	hussain	PROPN
ajlm-463	251	9	s	s	PROPN
ajlm-463	251	10	,	,	PUNCT
ajlm-463	251	11	et	et	PROPN
ajlm-463	251	12	al	al	PROPN
ajlm-463	251	13	.	.	PUNCT
ajlm-463	252	1	molecular	molecular	ADJ
ajlm-463	252	2	characterization	characterization	NOUN
ajlm-463	252	3	of	of	ADP
ajlm-463	252	4	multidrug	multidrug	NOUN
ajlm-463	252	5	-	-	PUNCT
ajlm-463	252	6	resistant	resistant	ADJ
ajlm-463	252	7	isolates	isolate	NOUN
ajlm-463	252	8	of	of	ADP
ajlm-463	252	9	mycobacterium	mycobacterium	NOUN
ajlm-463	252	10	tuberculosis	tuberculosis	NOUN
ajlm-463	252	11	from	from	ADP
ajlm-463	252	12	patients	patient	NOUN
ajlm-463	252	13	in	in	ADP
ajlm-463	252	14	north	north	PROPN
ajlm-463	252	15	india	india	PROPN
ajlm-463	252	16	.	.	PUNCT
ajlm-463	253	1	antimicrob	antimicrob	PROPN
ajlm-463	253	2	agents	agents	PROPN
ajlm-463	253	3	chemother	chemother	PROPN
ajlm-463	253	4	.	.	PUNCT
ajlm-463	254	1	2002;46(2):443–50	2002;46(2):443–50	X
ajlm-463	254	2	.	.	PUNCT
ajlm-463	255	1	varma	varma	NOUN
ajlm-463	255	2	-	-	PUNCT
ajlm-463	255	3	basil	basil	PROPN
ajlm-463	255	4	m	m	PROPN
ajlm-463	255	5	,	,	PUNCT
ajlm-463	255	6	el	el	PROPN
ajlm-463	255	7	-	-	PUNCT
ajlm-463	255	8	hajj	hajj	PROPN
ajlm-463	255	9	h	h	NOUN
ajlm-463	255	10	,	,	PUNCT
ajlm-463	255	11	colangeli	colangeli	PROPN
ajlm-463	255	12	r	r	NOUN
ajlm-463	255	13	,	,	PUNCT
ajlm-463	255	14	et	et	PROPN
ajlm-463	255	15	al	al	PROPN
ajlm-463	255	16	.	.	PROPN
ajlm-463	256	1	rapid	rapid	ADJ
ajlm-463	256	2	detection	detection	NOUN
ajlm-463	256	3	of	of	ADP
ajlm-463	256	4	rifampin	rifampin	NOUN
ajlm-463	256	5	resistance	resistance	NOUN
ajlm-463	256	6	in	in	ADP
ajlm-463	256	7	mycobacterium	mycobacterium	NOUN
ajlm-463	256	8	tuberculosis	tuberculosis	NOUN
ajlm-463	256	9	isolates	isolate	NOUN
ajlm-463	256	10	from	from	ADP
ajlm-463	256	11	india	india	PROPN
ajlm-463	256	12	and	and	CCONJ
ajlm-463	256	13	mexico	mexico	PROPN
ajlm-463	256	14	by	by	ADP
ajlm-463	256	15	a	a	DET
ajlm-463	256	16	molecular	molecular	ADJ
ajlm-463	256	17	beacon	beacon	NOUN
ajlm-463	256	18	assay	assay	NOUN
ajlm-463	256	19	.	.	PUNCT
ajlm-463	257	1	clin	clin	PROPN
ajlm-463	257	2	microbiol	microbiol	PROPN
ajlm-463	257	3	.	.	PUNCT
ajlm-463	258	1	2004;42(12):5512–5516	2004;42(12):5512–5516	NUM
ajlm-463	258	2	.	.	PUNCT
ajlm-463	259	1	https://doi.org/10.1128/jcm.42.12.5512-5516.2004	https://doi.org/10.1128/jcm.42.12.5512-5516.2004	PROPN
ajlm-463	259	2	lingala	lingala	PROPN
ajlm-463	259	3	mal	mal	PROPN
ajlm-463	259	4	,	,	PUNCT
ajlm-463	259	5	srikantam	srikantam	VERB
ajlm-463	259	6	a	a	DET
ajlm-463	259	7	,	,	PUNCT
ajlm-463	259	8	jain	jain	PROPN
ajlm-463	259	9	s	s	PART
ajlm-463	259	10	,	,	PUNCT
ajlm-463	259	11	et	et	PROPN
ajlm-463	259	12	al	al	PROPN
ajlm-463	259	13	.	.	PROPN
ajlm-463	260	1	clinical	clinical	ADJ
ajlm-463	260	2	and	and	CCONJ
ajlm-463	260	3	geographical	geographical	ADJ
ajlm-463	260	4	profiles	profile	NOUN
ajlm-463	260	5	of	of	ADP
ajlm-463	260	6	rpob	rpob	ADJ
ajlm-463	260	7	gene	gene	NOUN
ajlm-463	260	8	mutations	mutation	NOUN
ajlm-463	260	9	in	in	ADP
ajlm-463	260	10	mycobacterium	mycobacterium	NOUN
ajlm-463	260	11	tuberculosis	tuberculosis	NOUN
ajlm-463	260	12	isolates	isolate	NOUN
ajlm-463	260	13	from	from	ADP
ajlm-463	260	14	hyderabad	hyderabad	PROPN
ajlm-463	260	15	and	and	CCONJ
ajlm-463	260	16	koraput	koraput	PROPN
ajlm-463	260	17	in	in	ADP
ajlm-463	260	18	india	india	PROPN
ajlm-463	260	19	.	.	PUNCT
ajlm-463	261	1	j	j	PROPN
ajlm-463	261	2	microbiol	microbiol	PROPN
ajlm-463	261	3	antimicrob	antimicrob	PROPN
ajlm-463	261	4	.	.	PUNCT
ajlm-463	262	1	2010;2(2):13–18	2010;2(2):13–18	NUM
ajlm-463	262	2	.	.	PUNCT
ajlm-463	263	1	sanchez	sanchez	PROPN
ajlm-463	263	2	-	-	PUNCT
ajlm-463	263	3	padilla	padilla	PROPN
ajlm-463	263	4	e	e	PROPN
ajlm-463	263	5	,	,	PUNCT
ajlm-463	263	6	merker	merker	NOUN
ajlm-463	263	7	m	m	PROPN
ajlm-463	263	8	,	,	PUNCT
ajlm-463	263	9	beckert	beckert	NOUN
ajlm-463	263	10	p	p	NOUN
ajlm-463	263	11	,	,	PUNCT
ajlm-463	263	12	et	et	PROPN
ajlm-463	263	13	al	al	PROPN
ajlm-463	263	14	.	.	PUNCT
ajlm-463	263	15	detection	detection	NOUN
ajlm-463	263	16	of	of	ADP
ajlm-463	263	17	drug	drug	NOUN
ajlm-463	263	18	-	-	PUNCT
ajlm-463	263	19	resistant	resistant	ADJ
ajlm-463	263	20	tuberculosis	tuberculosis	NOUN
ajlm-463	263	21	by	by	ADP
ajlm-463	263	22	xpert	xpert	PROPN
ajlm-463	263	23	mtb	mtb	PROPN
ajlm-463	263	24	/	/	SYM
ajlm-463	263	25	rif	rif	PROPN
ajlm-463	263	26	in	in	ADP
ajlm-463	263	27	swaziland	swaziland	PROPN
ajlm-463	263	28	.	.	PUNCT
ajlm-463	264	1	n	n	PROPN
ajlm-463	264	2	engl	engl	PROPN
ajlm-463	264	3	j	j	PROPN
ajlm-463	264	4	med	med	PROPN
ajlm-463	264	5	.	.	PUNCT
ajlm-463	264	6	2015;372(12):1181–1182	2015;372(12):1181–1182	NUM
ajlm-463	264	7	.	.	PUNCT
ajlm-463	265	1	https://doi.org/10.1056/nejmc1413930	https://doi.org/10.1056/nejmc1413930	PROPN
ajlm-463	265	2	theron	theron	PROPN
ajlm-463	265	3	g	g	PROPN
ajlm-463	265	4	,	,	PUNCT
ajlm-463	265	5	peter	peter	PROPN
ajlm-463	265	6	j	j	PROPN
ajlm-463	265	7	,	,	PUNCT
ajlm-463	265	8	van	van	PROPN
ajlm-463	265	9	zyl	zyl	PROPN
ajlm-463	265	10	-	-	PUNCT
ajlm-463	265	11	smit	smit	PROPN
ajlm-463	265	12	r	r	PROPN
ajlm-463	265	13	,	,	PUNCT
ajlm-463	265	14	et	et	PROPN
ajlm-463	265	15	al	al	PROPN
ajlm-463	265	16	.	.	PUNCT
ajlm-463	265	17	evaluation	evaluation	NOUN
ajlm-463	265	18	of	of	ADP
ajlm-463	265	19	the	the	DET
ajlm-463	265	20	xpert	xpert	PROPN
ajlm-463	265	21	mtb	mtb	PROPN
ajlm-463	265	22	/	/	SYM
ajlm-463	265	23	rif	rif	PROPN
ajlm-463	265	24	assay	assay	NOUN
ajlm-463	265	25	for	for	ADP
ajlm-463	265	26	the	the	DET
ajlm-463	265	27	diagnosis	diagnosis	NOUN
ajlm-463	265	28	of	of	ADP
ajlm-463	265	29	pulmonary	pulmonary	ADJ
ajlm-463	265	30	tuberculosis	tuberculosis	NOUN
ajlm-463	265	31	in	in	ADP
ajlm-463	265	32	a	a	DET
ajlm-463	265	33	high	high	ADJ
ajlm-463	265	34	hiv	hiv	PROPN
ajlm-463	265	35	prevalence	prevalence	NOUN
ajlm-463	265	36	setting	set	VERB
ajlm-463	265	37	.	.	PUNCT
ajlm-463	266	1	am	be	AUX
ajlm-463	266	2	j	j	PROPN
ajlm-463	266	3	respir	respir	NOUN
ajlm-463	266	4	crit	crit	PROPN
ajlm-463	266	5	care	care	NOUN
ajlm-463	266	6	med	me	VERB
ajlm-463	266	7	.	.	PUNCT
ajlm-463	267	1	2011;184(1):132–140	2011;184(1):132–140	NUM
ajlm-463	267	2	.	.	PUNCT
ajlm-463	268	1	https://doi.org/10.1164/rccm.201101-0056oc	https://doi.org/10.1164/rccm.201101-0056oc	X
ajlm-463	268	2	comas	coma	NOUN
ajlm-463	269	1	i	i	PRON
ajlm-463	269	2	,	,	PUNCT
ajlm-463	269	3	borrell	borrell	PROPN
ajlm-463	269	4	s	s	PROPN
ajlm-463	269	5	,	,	PUNCT
ajlm-463	269	6	roetzer	roetzer	NOUN
ajlm-463	269	7	a	a	PRON
ajlm-463	269	8	,	,	PUNCT
ajlm-463	269	9	et	et	PROPN
ajlm-463	269	10	al	al	PROPN
ajlm-463	269	11	.	.	PUNCT
ajlm-463	269	12	whole	whole	ADJ
ajlm-463	269	13	-	-	PUNCT
ajlm-463	269	14	genome	genome	NOUN
ajlm-463	269	15	sequencing	sequencing	NOUN
ajlm-463	269	16	of	of	ADP
ajlm-463	269	17	rifampicin	rifampicin	VERB
ajlm-463	269	18	-	-	PUNCT
ajlm-463	269	19	resistant	resistant	ADJ
ajlm-463	269	20	m.	m.	NOUN
ajlm-463	269	21	tuberculosis	tuberculosis	NOUN
ajlm-463	269	22	strains	strain	NOUN
ajlm-463	269	23	identifies	identify	VERB
ajlm-463	269	24	compensatory	compensatory	ADJ
ajlm-463	269	25	mutations	mutation	NOUN
ajlm-463	269	26	in	in	ADP
ajlm-463	269	27	rna	rna	NOUN
ajlm-463	269	28	polymerase	polymerase	NOUN
ajlm-463	269	29	.	.	PUNCT
ajlm-463	270	1	nat	nat	PROPN
ajlm-463	270	2	genet	genet	PROPN
ajlm-463	270	3	.	.	PUNCT
ajlm-463	271	1	2011;44(1):106–110	2011;44(1):106–110	NUM
ajlm-463	271	2	.	.	PUNCT
ajlm-463	272	1	https://doi.org/10.1038/ng.1038	https://doi.org/10.1038/ng.1038	PROPN
ajlm-463	273	1	mariam	mariam	PROPN
ajlm-463	273	2	dh	dh	PROPN
ajlm-463	273	3	,	,	PUNCT
ajlm-463	273	4	mengistu	mengistu	PROPN
ajlm-463	273	5	y	y	PROPN
ajlm-463	273	6	,	,	PUNCT
ajlm-463	273	7	hoffner	hoffner	X
ajlm-463	273	8	se	se	PROPN
ajlm-463	273	9	,	,	PUNCT
ajlm-463	273	10	et	et	PROPN
ajlm-463	273	11	al	al	PROPN
ajlm-463	273	12	.	.	PROPN
ajlm-463	273	13	effect	effect	NOUN
ajlm-463	273	14	of	of	ADP
ajlm-463	273	15	rpob	rpob	ADJ
ajlm-463	273	16	mutations	mutation	NOUN
ajlm-463	273	17	conferring	confer	VERB
ajlm-463	273	18	rifampin	rifampin	NOUN
ajlm-463	273	19	resistance	resistance	NOUN
ajlm-463	273	20	on	on	ADP
ajlm-463	273	21	fitness	fitness	NOUN
ajlm-463	273	22	of	of	ADP
ajlm-463	273	23	mycobacterium	mycobacterium	NOUN
ajlm-463	273	24	tuberculosis	tuberculosis	NOUN
ajlm-463	273	25	.	.	PUNCT
ajlm-463	274	1	antimicrob	antimicrob	PROPN
ajlm-463	274	2	agents	agents	PROPN
ajlm-463	274	3	chemother	chemother	PROPN
ajlm-463	274	4	.	.	PUNCT
ajlm-463	275	1	2004;48(4):1289–1294	2004;48(4):1289–1294	NOUN
ajlm-463	275	2	.	.	PUNCT
ajlm-463	276	1	malawi	malawi	PROPN
ajlm-463	276	2	national	national	ADJ
ajlm-463	276	3	tuberculosis	tuberculosis	NOUN
ajlm-463	276	4	programme	programme	NOUN
ajlm-463	276	5	.	.	PUNCT
ajlm-463	277	1	national	national	ADJ
ajlm-463	277	2	tuberculosis	tuberculosis	NOUN
ajlm-463	277	3	control	control	NOUN
ajlm-463	277	4	programme	programme	NOUN
ajlm-463	277	5	manual	manual	NOUN
ajlm-463	277	6	.	.	PUNCT
ajlm-463	278	1	7th	7th	ADJ
ajlm-463	278	2	ed	ed	NOUN
ajlm-463	278	3	.	.	PUNCT
ajlm-463	279	1	lilongwe	lilongwe	PROPN
ajlm-463	279	2	,	,	PUNCT
ajlm-463	279	3	malawi	malawi	PROPN
ajlm-463	279	4	:	:	PUNCT
ajlm-463	279	5	ministry	ministry	PROPN
ajlm-463	279	6	of	of	ADP
ajlm-463	279	7	health	health	PROPN
ajlm-463	279	8	;	;	PUNCT
ajlm-463	279	9	2012	2012	NUM
ajlm-463	279	10	.	.	PUNCT
ajlm-463	280	1	mathema	mathema	PROPN
ajlm-463	280	2	b	b	NOUN
ajlm-463	280	3	,	,	PUNCT
ajlm-463	280	4	kurepina	kurepina	PROPN
ajlm-463	280	5	ne	ne	PROPN
ajlm-463	280	6	,	,	PUNCT
ajlm-463	280	7	fallows	fallow	NOUN
ajlm-463	280	8	d	d	NOUN
ajlm-463	280	9	,	,	PUNCT
ajlm-463	280	10	et	et	PROPN
ajlm-463	280	11	al	al	PROPN
ajlm-463	280	12	.	.	PUNCT
ajlm-463	280	13	lessons	lesson	NOUN
ajlm-463	280	14	from	from	ADP
ajlm-463	280	15	molecular	molecular	ADJ
ajlm-463	280	16	epidemiology	epidemiology	NOUN
ajlm-463	280	17	and	and	CCONJ
ajlm-463	280	18	comparative	comparative	ADJ
ajlm-463	280	19	genomics	genomic	NOUN
ajlm-463	280	20	.	.	PUNCT
ajlm-463	281	1	respir	respir	VERB
ajlm-463	281	2	crit	crit	PROPN
ajlm-463	281	3	care	care	NOUN
ajlm-463	281	4	med	me	VERB
ajlm-463	281	5	.	.	PUNCT
ajlm-463	282	1	2008;29(5):467–480	2008;29(5):467–480	NUM
ajlm-463	282	2	.	.	PUNCT
ajlm-463	283	1	https://doi.org/10.1055/s-0028-1085699	https://doi.org/10.1055/s-0028-1085699	NOUN