id	sid	tid	token	lemma	pos
ajlm-801	1	1	abstract	abstract	ADJ
ajlm-801	1	2	introduction	introduction	NOUN
ajlm-801	1	3	methods	method	NOUN
ajlm-801	1	4	results	result	VERB
ajlm-801	1	5	discussion	discussion	NOUN
ajlm-801	1	6	acknowledgements	acknowledgement	NOUN
ajlm-801	1	7	references	reference	NOUN
ajlm-801	1	8	about	about	ADP
ajlm-801	1	9	the	the	DET
ajlm-801	1	10	author(s	author(s	NOUN
ajlm-801	1	11	)	)	PUNCT
ajlm-801	1	12	shaheed	shaheed	NOUN
ajlm-801	1	13	v.	v.	ADP
ajlm-801	1	14	omar	omar	PROPN
ajlm-801	1	15	centre	centre	PROPN
ajlm-801	1	16	for	for	ADP
ajlm-801	1	17	tuberculosis	tuberculosis	NOUN
ajlm-801	1	18	,	,	PUNCT
ajlm-801	1	19	world	world	NOUN
ajlm-801	1	20	health	health	NOUN
ajlm-801	1	21	organization	organization	NOUN
ajlm-801	1	22	tb	tb	ADP
ajlm-801	1	23	supranational	supranational	ADJ
ajlm-801	1	24	reference	reference	NOUN
ajlm-801	1	25	laboratory	laboratory	NOUN
ajlm-801	1	26	network	network	NOUN
ajlm-801	1	27	,	,	PUNCT
ajlm-801	1	28	national	national	PROPN
ajlm-801	1	29	institute	institute	NOUN
ajlm-801	1	30	for	for	ADP
ajlm-801	1	31	communicable	communicable	NOUN
ajlm-801	1	32	diseases	disease	NOUN
ajlm-801	1	33	,	,	PUNCT
ajlm-801	1	34	national	national	PROPN
ajlm-801	1	35	health	health	PROPN
ajlm-801	1	36	laboratory	laboratory	PROPN
ajlm-801	1	37	service	service	PROPN
ajlm-801	1	38	,	,	PUNCT
ajlm-801	1	39	johannesburg	johannesburg	PROPN
ajlm-801	1	40	,	,	PUNCT
ajlm-801	1	41	south	south	PROPN
ajlm-801	1	42	africa	africa	PROPN
ajlm-801	1	43	lavania	lavania	PROPN
ajlm-801	1	44	joseph	joseph	PROPN
ajlm-801	1	45	centre	centre	PROPN
ajlm-801	1	46	for	for	ADP
ajlm-801	1	47	tuberculosis	tuberculosis	NOUN
ajlm-801	1	48	,	,	PUNCT
ajlm-801	1	49	world	world	NOUN
ajlm-801	1	50	health	health	NOUN
ajlm-801	1	51	organization	organization	NOUN
ajlm-801	1	52	tb	tb	ADP
ajlm-801	1	53	supranational	supranational	ADJ
ajlm-801	1	54	reference	reference	NOUN
ajlm-801	1	55	laboratory	laboratory	NOUN
ajlm-801	1	56	network	network	NOUN
ajlm-801	1	57	,	,	PUNCT
ajlm-801	1	58	national	national	PROPN
ajlm-801	1	59	institute	institute	NOUN
ajlm-801	1	60	for	for	ADP
ajlm-801	1	61	communicable	communicable	NOUN
ajlm-801	1	62	diseases	disease	NOUN
ajlm-801	1	63	,	,	PUNCT
ajlm-801	1	64	national	national	PROPN
ajlm-801	1	65	health	health	PROPN
ajlm-801	1	66	laboratory	laboratory	PROPN
ajlm-801	1	67	service	service	PROPN
ajlm-801	1	68	,	,	PUNCT
ajlm-801	1	69	johannesburg	johannesburg	PROPN
ajlm-801	1	70	,	,	PUNCT
ajlm-801	1	71	south	south	PROPN
ajlm-801	1	72	africa	africa	PROPN
ajlm-801	1	73	halima	halima	PROPN
ajlm-801	1	74	m.	m.	PROPN
ajlm-801	1	75	said	say	VERB
ajlm-801	1	76	centre	centre	NOUN
ajlm-801	1	77	for	for	ADP
ajlm-801	1	78	tuberculosis	tuberculosis	NOUN
ajlm-801	1	79	,	,	PUNCT
ajlm-801	1	80	world	world	NOUN
ajlm-801	1	81	health	health	NOUN
ajlm-801	1	82	organization	organization	NOUN
ajlm-801	1	83	tb	tb	ADP
ajlm-801	1	84	supranational	supranational	ADJ
ajlm-801	1	85	reference	reference	NOUN
ajlm-801	1	86	laboratory	laboratory	NOUN
ajlm-801	1	87	network	network	NOUN
ajlm-801	1	88	,	,	PUNCT
ajlm-801	1	89	national	national	PROPN
ajlm-801	1	90	institute	institute	NOUN
ajlm-801	1	91	for	for	ADP
ajlm-801	1	92	communicable	communicable	NOUN
ajlm-801	1	93	diseases	disease	NOUN
ajlm-801	1	94	,	,	PUNCT
ajlm-801	1	95	national	national	PROPN
ajlm-801	1	96	health	health	PROPN
ajlm-801	1	97	laboratory	laboratory	PROPN
ajlm-801	1	98	service	service	PROPN
ajlm-801	1	99	,	,	PUNCT
ajlm-801	1	100	johannesburg	johannesburg	PROPN
ajlm-801	1	101	,	,	PUNCT
ajlm-801	1	102	south	south	PROPN
ajlm-801	1	103	africa	africa	PROPN
ajlm-801	1	104	department	department	PROPN
ajlm-801	1	105	of	of	ADP
ajlm-801	1	106	medical	medical	ADJ
ajlm-801	1	107	microbiology	microbiology	NOUN
ajlm-801	1	108	,	,	PUNCT
ajlm-801	1	109	university	university	NOUN
ajlm-801	1	110	of	of	ADP
ajlm-801	1	111	the	the	DET
ajlm-801	1	112	free	free	ADJ
ajlm-801	1	113	state	state	PROPN
ajlm-801	1	114	,	,	PUNCT
ajlm-801	1	115	bloemfontein	bloemfontein	PROPN
ajlm-801	1	116	,	,	PUNCT
ajlm-801	1	117	south	south	PROPN
ajlm-801	1	118	africa	africa	PROPN
ajlm-801	1	119	farzana	farzana	PROPN
ajlm-801	1	120	ismail	ismail	PROPN
ajlm-801	1	121	centre	centre	PROPN
ajlm-801	1	122	for	for	ADP
ajlm-801	1	123	tuberculosis	tuberculosis	NOUN
ajlm-801	1	124	,	,	PUNCT
ajlm-801	1	125	world	world	NOUN
ajlm-801	1	126	health	health	NOUN
ajlm-801	1	127	organization	organization	NOUN
ajlm-801	1	128	tb	tb	ADP
ajlm-801	1	129	supranational	supranational	ADJ
ajlm-801	1	130	reference	reference	NOUN
ajlm-801	1	131	laboratory	laboratory	NOUN
ajlm-801	1	132	network	network	NOUN
ajlm-801	1	133	,	,	PUNCT
ajlm-801	1	134	national	national	PROPN
ajlm-801	1	135	institute	institute	NOUN
ajlm-801	1	136	for	for	ADP
ajlm-801	1	137	communicable	communicable	NOUN
ajlm-801	1	138	diseases	disease	NOUN
ajlm-801	1	139	,	,	PUNCT
ajlm-801	1	140	national	national	PROPN
ajlm-801	1	141	health	health	PROPN
ajlm-801	1	142	laboratory	laboratory	PROPN
ajlm-801	1	143	service	service	PROPN
ajlm-801	1	144	,	,	PUNCT
ajlm-801	1	145	johannesburg	johannesburg	PROPN
ajlm-801	1	146	,	,	PUNCT
ajlm-801	1	147	south	south	PROPN
ajlm-801	1	148	africa	africa	PROPN
ajlm-801	1	149	department	department	PROPN
ajlm-801	1	150	of	of	ADP
ajlm-801	1	151	medical	medical	ADJ
ajlm-801	1	152	microbiology	microbiology	NOUN
ajlm-801	1	153	,	,	PUNCT
ajlm-801	1	154	university	university	NOUN
ajlm-801	1	155	of	of	ADP
ajlm-801	1	156	pretoria	pretoria	PROPN
ajlm-801	1	157	,	,	PUNCT
ajlm-801	1	158	pretoria	pretoria	PROPN
ajlm-801	1	159	,	,	PUNCT
ajlm-801	1	160	south	south	PROPN
ajlm-801	1	161	africa	africa	PROPN
ajlm-801	1	162	nabila	nabila	PROPN
ajlm-801	1	163	ismail	ismail	PROPN
ajlm-801	1	164	centre	centre	PROPN
ajlm-801	1	165	for	for	ADP
ajlm-801	1	166	tuberculosis	tuberculosis	NOUN
ajlm-801	1	167	,	,	PUNCT
ajlm-801	1	168	world	world	NOUN
ajlm-801	1	169	health	health	NOUN
ajlm-801	1	170	organization	organization	NOUN
ajlm-801	1	171	tb	tb	ADP
ajlm-801	1	172	supranational	supranational	ADJ
ajlm-801	1	173	reference	reference	NOUN
ajlm-801	1	174	laboratory	laboratory	NOUN
ajlm-801	1	175	network	network	NOUN
ajlm-801	1	176	,	,	PUNCT
ajlm-801	1	177	national	national	PROPN
ajlm-801	1	178	institute	institute	NOUN
ajlm-801	1	179	for	for	ADP
ajlm-801	1	180	communicable	communicable	NOUN
ajlm-801	1	181	diseases	disease	NOUN
ajlm-801	1	182	,	,	PUNCT
ajlm-801	1	183	national	national	PROPN
ajlm-801	1	184	health	health	PROPN
ajlm-801	1	185	laboratory	laboratory	PROPN
ajlm-801	1	186	service	service	PROPN
ajlm-801	1	187	,	,	PUNCT
ajlm-801	1	188	johannesburg	johannesburg	PROPN
ajlm-801	1	189	,	,	PUNCT
ajlm-801	1	190	south	south	PROPN
ajlm-801	1	191	africa	africa	PROPN
ajlm-801	1	192	thabisile	thabisile	PROPN
ajlm-801	1	193	l.	l.	PROPN
ajlm-801	1	194	gwala	gwala	PROPN
ajlm-801	1	195	centre	centre	PROPN
ajlm-801	1	196	for	for	ADP
ajlm-801	1	197	tuberculosis	tuberculosis	NOUN
ajlm-801	1	198	,	,	PUNCT
ajlm-801	1	199	world	world	NOUN
ajlm-801	1	200	health	health	NOUN
ajlm-801	1	201	organization	organization	NOUN
ajlm-801	1	202	tb	tb	ADP
ajlm-801	1	203	supranational	supranational	ADJ
ajlm-801	1	204	reference	reference	NOUN
ajlm-801	1	205	laboratory	laboratory	NOUN
ajlm-801	1	206	network	network	NOUN
ajlm-801	1	207	,	,	PUNCT
ajlm-801	1	208	national	national	PROPN
ajlm-801	1	209	institute	institute	NOUN
ajlm-801	1	210	for	for	ADP
ajlm-801	1	211	communicable	communicable	NOUN
ajlm-801	1	212	diseases	disease	NOUN
ajlm-801	1	213	,	,	PUNCT
ajlm-801	1	214	national	national	PROPN
ajlm-801	1	215	health	health	PROPN
ajlm-801	1	216	laboratory	laboratory	PROPN
ajlm-801	1	217	service	service	PROPN
ajlm-801	1	218	,	,	PUNCT
ajlm-801	1	219	johannesburg	johannesburg	PROPN
ajlm-801	1	220	,	,	PUNCT
ajlm-801	1	221	south	south	PROPN
ajlm-801	1	222	africa	africa	PROPN
ajlm-801	1	223	nazir	nazir	PROPN
ajlm-801	1	224	a.	a.	PROPN
ajlm-801	1	225	ismail	ismail	PROPN
ajlm-801	1	226	centre	centre	PROPN
ajlm-801	1	227	for	for	ADP
ajlm-801	1	228	tuberculosis	tuberculosis	NOUN
ajlm-801	1	229	,	,	PUNCT
ajlm-801	1	230	world	world	NOUN
ajlm-801	1	231	health	health	NOUN
ajlm-801	1	232	organization	organization	NOUN
ajlm-801	1	233	tb	tb	ADP
ajlm-801	1	234	supranational	supranational	ADJ
ajlm-801	1	235	reference	reference	NOUN
ajlm-801	1	236	laboratory	laboratory	NOUN
ajlm-801	1	237	network	network	NOUN
ajlm-801	1	238	,	,	PUNCT
ajlm-801	1	239	national	national	PROPN
ajlm-801	1	240	institute	institute	NOUN
ajlm-801	1	241	for	for	ADP
ajlm-801	1	242	communicable	communicable	NOUN
ajlm-801	1	243	diseases	disease	NOUN
ajlm-801	1	244	,	,	PUNCT
ajlm-801	1	245	national	national	PROPN
ajlm-801	1	246	health	health	PROPN
ajlm-801	1	247	laboratory	laboratory	PROPN
ajlm-801	1	248	service	service	PROPN
ajlm-801	1	249	,	,	PUNCT
ajlm-801	1	250	johannesburg	johannesburg	PROPN
ajlm-801	1	251	,	,	PUNCT
ajlm-801	1	252	south	south	PROPN
ajlm-801	1	253	africa	africa	PROPN
ajlm-801	1	254	department	department	PROPN
ajlm-801	1	255	of	of	ADP
ajlm-801	1	256	medical	medical	ADJ
ajlm-801	1	257	microbiology	microbiology	NOUN
ajlm-801	1	258	,	,	PUNCT
ajlm-801	1	259	university	university	NOUN
ajlm-801	1	260	of	of	ADP
ajlm-801	1	261	pretoria	pretoria	PROPN
ajlm-801	1	262	,	,	PUNCT
ajlm-801	1	263	pretoria	pretoria	PROPN
ajlm-801	1	264	,	,	PUNCT
ajlm-801	1	265	south	south	PROPN
ajlm-801	1	266	africa	africa	PROPN
ajlm-801	1	267	citation	citation	PROPN
ajlm-801	1	268	omar	omar	PROPN
ajlm-801	1	269	sv	sv	PROPN
ajlm-801	1	270	,	,	PUNCT
ajlm-801	1	271	joseph	joseph	PROPN
ajlm-801	1	272	l	l	PROPN
ajlm-801	1	273	,	,	PUNCT
ajlm-801	1	274	said	say	VERB
ajlm-801	1	275	hm	hm	INTJ
ajlm-801	1	276	,	,	PUNCT
ajlm-801	1	277	et	et	PROPN
ajlm-801	2	1	al	al	PROPN
ajlm-801	2	2	.	.	PUNCT
ajlm-801	3	1	whole	whole	ADJ
ajlm-801	3	2	genome	genome	NOUN
ajlm-801	3	3	sequencing	sequencing	NOUN
ajlm-801	3	4	for	for	ADP
ajlm-801	3	5	drug	drug	NOUN
ajlm-801	3	6	resistance	resistance	NOUN
ajlm-801	3	7	determination	determination	NOUN
ajlm-801	3	8	in	in	ADP
ajlm-801	3	9	mycobacterium	mycobacterium	NOUN
ajlm-801	3	10	tuberculosis	tuberculosis	NOUN
ajlm-801	3	11	.	.	PUNCT
ajlm-801	4	1	afr	afr	PROPN
ajlm-801	4	2	j	j	PROPN
ajlm-801	4	3	lab	lab	PROPN
ajlm-801	4	4	med	med	PROPN
ajlm-801	4	5	.	.	PUNCT
ajlm-801	4	6	2019;8(1	2019;8(1	NOUN
ajlm-801	4	7	)	)	PUNCT
ajlm-801	4	8	,	,	PUNCT
ajlm-801	4	9	a801	a801	NUM
ajlm-801	4	10	.	.	PUNCT
ajlm-801	4	11	https://doi.org/10.4102/ajlm.v8i1.801	https://doi.org/10.4102/ajlm.v8i1.801	PROPN
ajlm-801	4	12	brief	brief	ADJ
ajlm-801	4	13	report	report	NOUN
ajlm-801	4	14	whole	whole	ADJ
ajlm-801	4	15	genome	genome	NOUN
ajlm-801	4	16	sequencing	sequencing	NOUN
ajlm-801	4	17	for	for	ADP
ajlm-801	4	18	drug	drug	NOUN
ajlm-801	4	19	resistance	resistance	NOUN
ajlm-801	4	20	determination	determination	NOUN
ajlm-801	4	21	in	in	ADP
ajlm-801	4	22	mycobacterium	mycobacterium	NOUN
ajlm-801	4	23	tuberculosis	tuberculosis	NOUN
ajlm-801	4	24	shaheed	shaheed	NOUN
ajlm-801	4	25	v.	v.	ADP
ajlm-801	4	26	omar	omar	PROPN
ajlm-801	4	27	,	,	PUNCT
ajlm-801	4	28	lavania	lavania	PROPN
ajlm-801	4	29	joseph	joseph	PROPN
ajlm-801	4	30	,	,	PUNCT
ajlm-801	4	31	halima	halima	PROPN
ajlm-801	4	32	m.	m.	PROPN
ajlm-801	4	33	said	say	VERB
ajlm-801	4	34	,	,	PUNCT
ajlm-801	4	35	farzana	farzana	PROPN
ajlm-801	4	36	ismail	ismail	PROPN
ajlm-801	4	37	,	,	PUNCT
ajlm-801	4	38	nabila	nabila	PROPN
ajlm-801	4	39	ismail	ismail	PROPN
ajlm-801	4	40	,	,	PUNCT
ajlm-801	4	41	thabisile	thabisile	PROPN
ajlm-801	4	42	l.	l.	PROPN
ajlm-801	4	43	gwala	gwala	PROPN
ajlm-801	4	44	,	,	PUNCT
ajlm-801	4	45	nazir	nazir	PROPN
ajlm-801	4	46	a.	a.	PROPN
ajlm-801	4	47	ismail	ismail	PROPN
ajlm-801	4	48	received	receive	VERB
ajlm-801	4	49	:	:	PUNCT
ajlm-801	4	50	07	07	NUM
ajlm-801	4	51	mar	mar	PROPN
ajlm-801	4	52	.	.	PROPN
ajlm-801	4	53	2018	2018	NUM
ajlm-801	4	54	;	;	PUNCT
ajlm-801	4	55	accepted	accept	VERB
ajlm-801	4	56	:	:	PUNCT
ajlm-801	4	57	28	28	NUM
ajlm-801	4	58	sept	sept	PROPN
ajlm-801	4	59	.	.	PROPN
ajlm-801	4	60	2018	2018	NUM
ajlm-801	4	61	;	;	PUNCT
ajlm-801	4	62	published	publish	VERB
ajlm-801	4	63	:	:	PUNCT
ajlm-801	4	64	21	21	NUM
ajlm-801	4	65	feb	feb	NOUN
ajlm-801	4	66	.	.	PROPN
ajlm-801	5	1	2019	2019	NUM
ajlm-801	5	2	copyright	copyright	NOUN
ajlm-801	5	3	:	:	PUNCT
ajlm-801	5	4	©	©	PROPN
ajlm-801	5	5	2019	2019	NUM
ajlm-801	5	6	.	.	PUNCT
ajlm-801	6	1	the	the	DET
ajlm-801	6	2	author(s	author(s	PROPN
ajlm-801	6	3	)	)	PUNCT
ajlm-801	6	4	.	.	PUNCT
ajlm-801	7	1	licensee	licensee	NOUN
ajlm-801	7	2	:	:	PUNCT
ajlm-801	7	3	aosis	aosis	NOUN
ajlm-801	7	4	.	.	PUNCT
ajlm-801	8	1	this	this	PRON
ajlm-801	8	2	is	be	AUX
ajlm-801	8	3	an	an	DET
ajlm-801	8	4	open	open	ADJ
ajlm-801	8	5	access	access	NOUN
ajlm-801	8	6	article	article	NOUN
ajlm-801	8	7	distributed	distribute	VERB
ajlm-801	8	8	under	under	ADP
ajlm-801	8	9	the	the	DET
ajlm-801	8	10	terms	term	NOUN
ajlm-801	8	11	of	of	ADP
ajlm-801	8	12	the	the	DET
ajlm-801	8	13	creative	creative	ADJ
ajlm-801	8	14	commons	common	NOUN
ajlm-801	8	15	attribution	attribution	NOUN
ajlm-801	8	16	license	license	NOUN
ajlm-801	8	17	,	,	PUNCT
ajlm-801	8	18	which	which	PRON
ajlm-801	8	19	permits	permit	VERB
ajlm-801	8	20	unrestricted	unrestricted	ADJ
ajlm-801	8	21	use	use	NOUN
ajlm-801	8	22	,	,	PUNCT
ajlm-801	8	23	distribution	distribution	NOUN
ajlm-801	8	24	,	,	PUNCT
ajlm-801	8	25	and	and	CCONJ
ajlm-801	8	26	reproduction	reproduction	NOUN
ajlm-801	8	27	in	in	ADP
ajlm-801	8	28	any	any	DET
ajlm-801	8	29	medium	medium	NOUN
ajlm-801	8	30	,	,	PUNCT
ajlm-801	8	31	provided	provide	VERB
ajlm-801	8	32	the	the	DET
ajlm-801	8	33	original	original	ADJ
ajlm-801	8	34	work	work	NOUN
ajlm-801	8	35	is	be	AUX
ajlm-801	8	36	properly	properly	ADV
ajlm-801	8	37	cited	cite	VERB
ajlm-801	8	38	.	.	PUNCT
ajlm-801	9	1	abstract	abstract	PROPN
ajlm-801	9	2	south	south	PROPN
ajlm-801	9	3	africa	africa	PROPN
ajlm-801	9	4	remains	remains	AUX
ajlm-801	9	5	challenged	challenge	VERB
ajlm-801	9	6	with	with	ADP
ajlm-801	9	7	a	a	DET
ajlm-801	9	8	high	high	ADJ
ajlm-801	9	9	tuberculosis	tuberculosis	NOUN
ajlm-801	9	10	burden	burden	NOUN
ajlm-801	9	11	accompanied	accompany	VERB
ajlm-801	9	12	by	by	ADP
ajlm-801	9	13	an	an	DET
ajlm-801	9	14	increase	increase	NOUN
ajlm-801	9	15	in	in	ADP
ajlm-801	9	16	drug	drug	NOUN
ajlm-801	9	17	resistant	resistant	ADJ
ajlm-801	9	18	cases	case	NOUN
ajlm-801	9	19	.	.	PUNCT
ajlm-801	10	1	we	we	PRON
ajlm-801	10	2	assessed	assess	VERB
ajlm-801	10	3	the	the	DET
ajlm-801	10	4	use	use	NOUN
ajlm-801	10	5	of	of	ADP
ajlm-801	10	6	the	the	DET
ajlm-801	10	7	illumina	illumina	PROPN
ajlm-801	10	8	miseq	miseq	PROPN
ajlm-801	10	9	,	,	PUNCT
ajlm-801	10	10	a	a	DET
ajlm-801	10	11	next	next	ADJ
ajlm-801	10	12	-	-	PUNCT
ajlm-801	10	13	generation	generation	NOUN
ajlm-801	10	14	sequencing	sequence	VERB
ajlm-801	10	15	platform	platform	NOUN
ajlm-801	10	16	for	for	ADP
ajlm-801	10	17	whole	whole	ADJ
ajlm-801	10	18	genome	genome	NOUN
ajlm-801	10	19	sequencing	sequencing	NOUN
ajlm-801	10	20	,	,	PUNCT
ajlm-801	10	21	followed	follow	VERB
ajlm-801	10	22	by	by	ADP
ajlm-801	10	23	bioinformatic	bioinformatic	ADJ
ajlm-801	10	24	analysis	analysis	NOUN
ajlm-801	10	25	using	use	VERB
ajlm-801	10	26	a	a	DET
ajlm-801	10	27	commercial	commercial	ADJ
ajlm-801	10	28	software	software	NOUN
ajlm-801	10	29	package	package	NOUN
ajlm-801	10	30	to	to	PART
ajlm-801	10	31	determine	determine	VERB
ajlm-801	10	32	resistance	resistance	NOUN
ajlm-801	10	33	to	to	ADP
ajlm-801	10	34	selected	select	VERB
ajlm-801	10	35	drugs	drug	NOUN
ajlm-801	10	36	used	use	VERB
ajlm-801	10	37	for	for	ADP
ajlm-801	10	38	mycobacterium	mycobacterium	NOUN
ajlm-801	10	39	tuberculosis	tuberculosis	NOUN
ajlm-801	10	40	treatment	treatment	NOUN
ajlm-801	10	41	in	in	ADP
ajlm-801	10	42	our	our	PRON
ajlm-801	10	43	setting	setting	NOUN
ajlm-801	10	44	.	.	PUNCT
ajlm-801	11	1	whole	whole	ADJ
ajlm-801	11	2	genome	genome	NOUN
ajlm-801	11	3	sequencing	sequencing	NOUN
ajlm-801	11	4	shows	show	NOUN
ajlm-801	11	5	potential	potential	NOUN
ajlm-801	11	6	as	as	ADP
ajlm-801	11	7	a	a	DET
ajlm-801	11	8	diagnostic	diagnostic	ADJ
ajlm-801	11	9	platform	platform	NOUN
ajlm-801	11	10	for	for	ADP
ajlm-801	11	11	the	the	DET
ajlm-801	11	12	detection	detection	NOUN
ajlm-801	11	13	of	of	ADP
ajlm-801	11	14	drug	drug	NOUN
ajlm-801	11	15	resistance	resistance	NOUN
ajlm-801	11	16	in	in	ADP
ajlm-801	11	17	mycobacterium	mycobacterium	NOUN
ajlm-801	11	18	tuberculosis	tuberculosis	NOUN
ajlm-801	11	19	with	with	ADP
ajlm-801	11	20	the	the	DET
ajlm-801	11	21	provision	provision	NOUN
ajlm-801	11	22	of	of	ADP
ajlm-801	11	23	information	information	NOUN
ajlm-801	11	24	for	for	ADP
ajlm-801	11	25	several	several	ADJ
ajlm-801	11	26	drugs	drug	NOUN
ajlm-801	11	27	simultaneously	simultaneously	ADV
ajlm-801	11	28	.	.	PUNCT
ajlm-801	12	1	introduction	introduction	NOUN
ajlm-801	12	2	drug	drug	NOUN
ajlm-801	12	3	-	-	PUNCT
ajlm-801	12	4	resistant	resistant	ADJ
ajlm-801	12	5	tuberculosis	tuberculosis	NOUN
ajlm-801	12	6	poses	pose	VERB
ajlm-801	12	7	a	a	DET
ajlm-801	12	8	significant	significant	ADJ
ajlm-801	12	9	challenge	challenge	NOUN
ajlm-801	12	10	to	to	ADP
ajlm-801	12	11	tuberculosis	tuberculosis	PRON
ajlm-801	12	12	control	control	NOUN
ajlm-801	12	13	programmes	programme	NOUN
ajlm-801	12	14	in	in	ADP
ajlm-801	12	15	high	high	ADJ
ajlm-801	12	16	burden	burden	NOUN
ajlm-801	12	17	settings.1	settings.1	PROPN
ajlm-801	12	18	undiagnosed	undiagnosed	ADJ
ajlm-801	12	19	drug	drug	NOUN
ajlm-801	12	20	resistance	resistance	NOUN
ajlm-801	12	21	leads	lead	VERB
ajlm-801	12	22	to	to	ADP
ajlm-801	12	23	further	further	ADJ
ajlm-801	12	24	transmission	transmission	NOUN
ajlm-801	12	25	,	,	PUNCT
ajlm-801	12	26	poor	poor	ADJ
ajlm-801	12	27	patient	patient	ADJ
ajlm-801	12	28	outcomes	outcome	NOUN
ajlm-801	12	29	and	and	CCONJ
ajlm-801	12	30	potential	potential	ADJ
ajlm-801	12	31	for	for	ADP
ajlm-801	12	32	amplification	amplification	NOUN
ajlm-801	12	33	of	of	ADP
ajlm-801	12	34	drug	drug	NOUN
ajlm-801	12	35	resistance	resistance	NOUN
ajlm-801	12	36	,	,	PUNCT
ajlm-801	12	37	impeding	impede	VERB
ajlm-801	12	38	the	the	DET
ajlm-801	12	39	world	world	NOUN
ajlm-801	12	40	health	health	PROPN
ajlm-801	12	41	organization	organization	PROPN
ajlm-801	12	42	’s	’s	PART
ajlm-801	12	43	(	(	PUNCT
ajlm-801	12	44	who	who	PRON
ajlm-801	12	45	)	)	PUNCT
ajlm-801	12	46	strategy	strategy	NOUN
ajlm-801	12	47	to	to	PART
ajlm-801	12	48	end	end	VERB
ajlm-801	12	49	tuberculosis	tuberculosis	NOUN
ajlm-801	12	50	by	by	ADP
ajlm-801	12	51	2035	2035	NUM
ajlm-801	12	52	.	.	PUNCT
ajlm-801	13	1	the	the	DET
ajlm-801	13	2	drug	drug	NOUN
ajlm-801	13	3	-	-	PUNCT
ajlm-801	13	4	resistant	resistant	ADJ
ajlm-801	13	5	tuberculosis	tuberculosis	NOUN
ajlm-801	13	6	outbreaks	outbreak	NOUN
ajlm-801	13	7	in	in	ADP
ajlm-801	13	8	tugela	tugela	ADP
ajlm-801	13	9	ferry2	ferry2	PROPN
ajlm-801	13	10	and	and	CCONJ
ajlm-801	13	11	other	other	ADJ
ajlm-801	13	12	regions	region	NOUN
ajlm-801	13	13	of	of	ADP
ajlm-801	13	14	south	south	PROPN
ajlm-801	13	15	africa3	africa3	PROPN
ajlm-801	13	16	highlight	highlight	VERB
ajlm-801	13	17	the	the	DET
ajlm-801	13	18	need	need	NOUN
ajlm-801	13	19	for	for	ADP
ajlm-801	13	20	early	early	ADJ
ajlm-801	13	21	and	and	CCONJ
ajlm-801	13	22	accurate	accurate	ADJ
ajlm-801	13	23	diagnosis	diagnosis	NOUN
ajlm-801	13	24	of	of	ADP
ajlm-801	13	25	drug	drug	NOUN
ajlm-801	13	26	resistance	resistance	NOUN
ajlm-801	13	27	.	.	PUNCT
ajlm-801	14	1	often	often	ADV
ajlm-801	14	2	,	,	PUNCT
ajlm-801	14	3	comprehensive	comprehensive	ADJ
ajlm-801	14	4	phenotypic	phenotypic	NOUN
ajlm-801	14	5	baseline	baseline	NOUN
ajlm-801	14	6	testing	testing	NOUN
ajlm-801	14	7	is	be	AUX
ajlm-801	14	8	not	not	PART
ajlm-801	14	9	available	available	ADJ
ajlm-801	14	10	nor	nor	CCONJ
ajlm-801	14	11	is	be	AUX
ajlm-801	14	12	a	a	DET
ajlm-801	14	13	robust	robust	ADJ
ajlm-801	14	14	surveillance	surveillance	NOUN
ajlm-801	14	15	programme	programme	NOUN
ajlm-801	14	16	in	in	ADP
ajlm-801	14	17	place	place	NOUN
ajlm-801	14	18	to	to	PART
ajlm-801	14	19	inform	inform	VERB
ajlm-801	14	20	regimen	regimen	NOUN
ajlm-801	14	21	changes	change	NOUN
ajlm-801	14	22	appropriate	appropriate	ADJ
ajlm-801	14	23	to	to	ADP
ajlm-801	14	24	local	local	ADJ
ajlm-801	14	25	resistance	resistance	NOUN
ajlm-801	14	26	profiles.4	profiles.4	PROPN
ajlm-801	14	27	a	a	DET
ajlm-801	14	28	paradigm	paradigm	NOUN
ajlm-801	14	29	shift	shift	NOUN
ajlm-801	14	30	is	be	AUX
ajlm-801	14	31	needed	need	VERB
ajlm-801	14	32	in	in	ADP
ajlm-801	14	33	the	the	DET
ajlm-801	14	34	approach	approach	NOUN
ajlm-801	14	35	to	to	ADP
ajlm-801	14	36	diagnosis	diagnosis	NOUN
ajlm-801	14	37	and	and	CCONJ
ajlm-801	14	38	surveillance	surveillance	NOUN
ajlm-801	14	39	of	of	ADP
ajlm-801	14	40	drug	drug	NOUN
ajlm-801	14	41	-	-	PUNCT
ajlm-801	14	42	resistant	resistant	ADJ
ajlm-801	14	43	tuberculosis	tuberculosis	NOUN
ajlm-801	14	44	to	to	PART
ajlm-801	14	45	ensure	ensure	VERB
ajlm-801	14	46	that	that	SCONJ
ajlm-801	14	47	new	new	ADJ
ajlm-801	14	48	drug	drug	NOUN
ajlm-801	14	49	potential	potential	NOUN
ajlm-801	14	50	is	be	AUX
ajlm-801	14	51	not	not	PART
ajlm-801	14	52	lost	lose	VERB
ajlm-801	14	53	due	due	ADJ
ajlm-801	14	54	to	to	ADP
ajlm-801	14	55	the	the	DET
ajlm-801	14	56	evolution	evolution	NOUN
ajlm-801	14	57	and	and	CCONJ
ajlm-801	14	58	spread	spread	VERB
ajlm-801	14	59	of	of	ADP
ajlm-801	14	60	resistant	resistant	ADJ
ajlm-801	14	61	strains	strain	NOUN
ajlm-801	14	62	.	.	PUNCT
ajlm-801	15	1	molecular	molecular	ADJ
ajlm-801	15	2	testing	testing	NOUN
ajlm-801	15	3	such	such	ADJ
ajlm-801	15	4	as	as	ADP
ajlm-801	15	5	the	the	DET
ajlm-801	15	6	line	line	NOUN
ajlm-801	15	7	probe	probe	NOUN
ajlm-801	15	8	assay	assay	PROPN
ajlm-801	15	9	and	and	CCONJ
ajlm-801	15	10	xpert	xpert	PROPN
ajlm-801	15	11	mtb	mtb	PROPN
ajlm-801	15	12	/	/	SYM
ajlm-801	15	13	rif	rif	PROPN
ajlm-801	15	14	assay	assay	PROPN
ajlm-801	15	15	(	(	PUNCT
ajlm-801	15	16	cepheid	cepheid	PROPN
ajlm-801	15	17	,	,	PUNCT
ajlm-801	15	18	sunnyvale	sunnyvale	PROPN
ajlm-801	15	19	,	,	PUNCT
ajlm-801	15	20	california	california	PROPN
ajlm-801	15	21	,	,	PUNCT
ajlm-801	15	22	united	united	PROPN
ajlm-801	15	23	states	states	PROPN
ajlm-801	15	24	)	)	PUNCT
ajlm-801	15	25	show	show	VERB
ajlm-801	15	26	potential	potential	ADJ
ajlm-801	15	27	superiority	superiority	NOUN
ajlm-801	15	28	in	in	ADP
ajlm-801	15	29	overall	overall	ADJ
ajlm-801	15	30	performance	performance	NOUN
ajlm-801	15	31	over	over	ADP
ajlm-801	15	32	phenotypic	phenotypic	ADJ
ajlm-801	15	33	drug	drug	NOUN
ajlm-801	15	34	susceptibility	susceptibility	NOUN
ajlm-801	15	35	testing	testing	NOUN
ajlm-801	15	36	(	(	PUNCT
ajlm-801	15	37	dst).5,6	dst).5,6	NOUN
ajlm-801	15	38	a	a	DET
ajlm-801	15	39	targeted	target	VERB
ajlm-801	15	40	sequencing	sequence	VERB
ajlm-801	15	41	approach	approach	NOUN
ajlm-801	15	42	for	for	ADP
ajlm-801	15	43	resistance	resistance	NOUN
ajlm-801	15	44	detection	detection	NOUN
ajlm-801	15	45	in	in	ADP
ajlm-801	15	46	mycobacterium	mycobacterium	NOUN
ajlm-801	15	47	tuberculosis	tuberculosis	NOUN
ajlm-801	15	48	by	by	ADP
ajlm-801	15	49	application	application	NOUN
ajlm-801	15	50	of	of	ADP
ajlm-801	15	51	next	next	ADJ
ajlm-801	15	52	-	-	PUNCT
ajlm-801	15	53	generation	generation	NOUN
ajlm-801	15	54	sequencing	sequence	VERB
ajlm-801	15	55	benchtop	benchtop	NOUN
ajlm-801	15	56	platforms	platform	NOUN
ajlm-801	15	57	showed	show	VERB
ajlm-801	15	58	good	good	ADJ
ajlm-801	15	59	performance	performance	NOUN
ajlm-801	15	60	in	in	ADP
ajlm-801	15	61	terms	term	NOUN
ajlm-801	15	62	of	of	ADP
ajlm-801	15	63	sensitivity.7	sensitivity.7	NOUN
ajlm-801	15	64	with	with	SCONJ
ajlm-801	15	65	the	the	DET
ajlm-801	15	66	decreasing	decrease	VERB
ajlm-801	15	67	cost	cost	NOUN
ajlm-801	15	68	of	of	ADP
ajlm-801	15	69	next	next	ADJ
ajlm-801	15	70	-	-	PUNCT
ajlm-801	15	71	generation	generation	NOUN
ajlm-801	15	72	sequencing	sequencing	NOUN
ajlm-801	15	73	,	,	PUNCT
ajlm-801	15	74	whole	whole	ADJ
ajlm-801	15	75	genome	genome	NOUN
ajlm-801	15	76	sequencing	sequence	VERB
ajlm-801	15	77	(	(	PUNCT
ajlm-801	15	78	wgs	wgs	NOUN
ajlm-801	15	79	)	)	PUNCT
ajlm-801	15	80	could	could	AUX
ajlm-801	15	81	be	be	AUX
ajlm-801	15	82	applied	apply	VERB
ajlm-801	15	83	for	for	ADP
ajlm-801	15	84	this	this	DET
ajlm-801	15	85	purpose	purpose	NOUN
ajlm-801	15	86	as	as	ADP
ajlm-801	15	87	an	an	DET
ajlm-801	15	88	alternative	alternative	NOUN
ajlm-801	15	89	to	to	ADP
ajlm-801	15	90	conventional	conventional	ADJ
ajlm-801	15	91	phenotypic	phenotypic	NOUN
ajlm-801	15	92	methods.8,9	methods.8,9	NOUN
ajlm-801	15	93	the	the	DET
ajlm-801	15	94	direct	direct	ADJ
ajlm-801	15	95	benefit	benefit	NOUN
ajlm-801	15	96	of	of	ADP
ajlm-801	15	97	wgs	wgs	NOUN
ajlm-801	15	98	is	be	AUX
ajlm-801	15	99	its	its	PRON
ajlm-801	15	100	ability	ability	NOUN
ajlm-801	15	101	to	to	PART
ajlm-801	15	102	provide	provide	VERB
ajlm-801	15	103	organism	organism	NOUN
ajlm-801	15	104	identification	identification	NOUN
ajlm-801	15	105	,	,	PUNCT
ajlm-801	15	106	strain	strain	NOUN
ajlm-801	15	107	relatedness	relatedness	NOUN
ajlm-801	15	108	and	and	CCONJ
ajlm-801	15	109	a	a	DET
ajlm-801	15	110	drug	drug	NOUN
ajlm-801	15	111	resistance	resistance	NOUN
ajlm-801	15	112	profile	profile	NOUN
ajlm-801	15	113	for	for	ADP
ajlm-801	15	114	characterised	characterised	ADJ
ajlm-801	15	115	resistance	resistance	NOUN
ajlm-801	15	116	-	-	PUNCT
ajlm-801	15	117	conferring	confer	VERB
ajlm-801	15	118	mutations	mutation	NOUN
ajlm-801	15	119	.	.	PUNCT
ajlm-801	16	1	in	in	ADP
ajlm-801	16	2	addition	addition	NOUN
ajlm-801	16	3	,	,	PUNCT
ajlm-801	16	4	wgs	wgs	NOUN
ajlm-801	16	5	may	may	AUX
ajlm-801	16	6	be	be	AUX
ajlm-801	16	7	useful	useful	ADJ
ajlm-801	16	8	for	for	ADP
ajlm-801	16	9	resistance	resistance	NOUN
ajlm-801	16	10	determination	determination	NOUN
ajlm-801	16	11	for	for	ADP
ajlm-801	16	12	newer	new	ADJ
ajlm-801	16	13	drugs	drug	NOUN
ajlm-801	16	14	lacking	lack	VERB
ajlm-801	16	15	validated	validated	ADJ
ajlm-801	16	16	dst	dst	NOUN
ajlm-801	16	17	such	such	ADJ
ajlm-801	16	18	as	as	ADP
ajlm-801	16	19	bedaquiline	bedaquiline	NOUN
ajlm-801	16	20	and	and	CCONJ
ajlm-801	16	21	delamanid	delamanid	ADJ
ajlm-801	16	22	,	,	PUNCT
ajlm-801	16	23	utilising	utilise	VERB
ajlm-801	16	24	information	information	NOUN
ajlm-801	16	25	available	available	ADJ
ajlm-801	16	26	for	for	ADP
ajlm-801	16	27	the	the	DET
ajlm-801	16	28	genetic	genetic	ADJ
ajlm-801	16	29	basis	basis	NOUN
ajlm-801	16	30	associated	associate	VERB
ajlm-801	16	31	with	with	ADP
ajlm-801	16	32	resistance	resistance	NOUN
ajlm-801	16	33	in	in	ADP
ajlm-801	16	34	vitro	vitro	X
ajlm-801	16	35	to	to	ADP
ajlm-801	16	36	these	these	DET
ajlm-801	16	37	novel	novel	ADJ
ajlm-801	16	38	drugs.10,11	drugs.10,11	NOUN
ajlm-801	16	39	we	we	PRON
ajlm-801	16	40	assessed	assess	VERB
ajlm-801	16	41	the	the	DET
ajlm-801	16	42	use	use	NOUN
ajlm-801	16	43	of	of	ADP
ajlm-801	16	44	the	the	DET
ajlm-801	16	45	illumina	illumina	PROPN
ajlm-801	16	46	miseq	miseq	PROPN
ajlm-801	16	47	®	®	NOUN
ajlm-801	16	48	sequencing,12	sequencing,12	NOUN
ajlm-801	16	49	followed	follow	VERB
ajlm-801	16	50	by	by	ADP
ajlm-801	16	51	bioinformatic	bioinformatic	ADJ
ajlm-801	16	52	analysis	analysis	NOUN
ajlm-801	16	53	using	use	VERB
ajlm-801	16	54	a	a	DET
ajlm-801	16	55	commercial	commercial	ADJ
ajlm-801	16	56	software	software	NOUN
ajlm-801	16	57	(	(	PUNCT
ajlm-801	16	58	clc	clc	PROPN
ajlm-801	16	59	genomics	genomics	NOUN
ajlm-801	16	60	workbench	workbench	NOUN
ajlm-801	16	61	,	,	PUNCT
ajlm-801	16	62	qiagen	qiagen	NOUN
ajlm-801	16	63	,	,	PUNCT
ajlm-801	16	64	venlo	venlo	PROPN
ajlm-801	16	65	,	,	PUNCT
ajlm-801	16	66	the	the	DET
ajlm-801	16	67	netherlands	netherlands	PROPN
ajlm-801	16	68	)	)	PUNCT
ajlm-801	16	69	for	for	ADP
ajlm-801	16	70	drug	drug	NOUN
ajlm-801	16	71	resistance	resistance	NOUN
ajlm-801	16	72	determination	determination	NOUN
ajlm-801	16	73	at	at	ADP
ajlm-801	16	74	the	the	DET
ajlm-801	16	75	national	national	ADJ
ajlm-801	16	76	tuberculosis	tuberculosis	NOUN
ajlm-801	16	77	reference	reference	NOUN
ajlm-801	16	78	laboratory	laboratory	NOUN
ajlm-801	16	79	in	in	ADP
ajlm-801	16	80	south	south	PROPN
ajlm-801	16	81	africa	africa	PROPN
ajlm-801	16	82	.	.	PUNCT
ajlm-801	17	1	methods	method	NOUN
ajlm-801	17	2	ethical	ethical	ADJ
ajlm-801	17	3	considerations	consideration	NOUN
ajlm-801	17	4	ethical	ethical	ADJ
ajlm-801	17	5	approval	approval	NOUN
ajlm-801	17	6	was	be	AUX
ajlm-801	17	7	not	not	PART
ajlm-801	17	8	required	require	VERB
ajlm-801	17	9	for	for	ADP
ajlm-801	17	10	this	this	DET
ajlm-801	17	11	laboratory	laboratory	NOUN
ajlm-801	17	12	-	-	PUNCT
ajlm-801	17	13	based	base	VERB
ajlm-801	17	14	study	study	NOUN
ajlm-801	17	15	as	as	SCONJ
ajlm-801	17	16	only	only	ADV
ajlm-801	17	17	anonymised	anonymise	VERB
ajlm-801	17	18	isolates	isolate	NOUN
ajlm-801	17	19	were	be	AUX
ajlm-801	17	20	used	use	VERB
ajlm-801	17	21	.	.	PUNCT
ajlm-801	18	1	sample	sample	NOUN
ajlm-801	18	2	selection	selection	NOUN
ajlm-801	18	3	twenty	twenty	NUM
ajlm-801	18	4	geographically	geographically	ADV
ajlm-801	18	5	diverse	diverse	ADJ
ajlm-801	18	6	clinically	clinically	ADV
ajlm-801	18	7	isolated	isolate	VERB
ajlm-801	18	8	m.	m.	NOUN
ajlm-801	18	9	tuberculosis	tuberculosis	NOUN
ajlm-801	18	10	strains	strain	NOUN
ajlm-801	18	11	,	,	PUNCT
ajlm-801	18	12	with	with	ADP
ajlm-801	18	13	varying	vary	VERB
ajlm-801	18	14	resistance	resistance	NOUN
ajlm-801	18	15	profiles	profile	NOUN
ajlm-801	18	16	and	and	CCONJ
ajlm-801	18	17	spoligotype	spoligotype	NOUN
ajlm-801	18	18	patterns	pattern	NOUN
ajlm-801	18	19	,	,	PUNCT
ajlm-801	18	20	isolated	isolate	VERB
ajlm-801	18	21	between	between	ADP
ajlm-801	18	22	june	june	PROPN
ajlm-801	18	23	2012	2012	NUM
ajlm-801	18	24	and	and	CCONJ
ajlm-801	18	25	january	january	PROPN
ajlm-801	18	26	2013	2013	NUM
ajlm-801	18	27	were	be	AUX
ajlm-801	18	28	selected	select	VERB
ajlm-801	18	29	for	for	ADP
ajlm-801	18	30	this	this	DET
ajlm-801	18	31	pilot	pilot	NOUN
ajlm-801	18	32	evaluation	evaluation	NOUN
ajlm-801	18	33	(	(	PUNCT
ajlm-801	18	34	table	table	NOUN
ajlm-801	18	35	1	1	NUM
ajlm-801	18	36	)	)	PUNCT
ajlm-801	18	37	.	.	PUNCT
ajlm-801	19	1	laboratory	laboratory	NOUN
ajlm-801	19	2	processing	processing	NOUN
ajlm-801	19	3	for	for	ADP
ajlm-801	19	4	culture	culture	NOUN
ajlm-801	19	5	,	,	PUNCT
ajlm-801	19	6	smear	smear	NOUN
ajlm-801	19	7	microscopy	microscopy	NOUN
ajlm-801	19	8	and	and	CCONJ
ajlm-801	19	9	dst	dst	PROPN
ajlm-801	19	10	were	be	AUX
ajlm-801	19	11	performed	perform	VERB
ajlm-801	19	12	according	accord	VERB
ajlm-801	19	13	to	to	ADP
ajlm-801	19	14	who	who	PRON
ajlm-801	19	15	guidelines.13	guidelines.13	VERB
ajlm-801	19	16	six	six	NUM
ajlm-801	19	17	of	of	ADP
ajlm-801	19	18	the	the	DET
ajlm-801	19	19	20	20	NUM
ajlm-801	19	20	isolates	isolate	NOUN
ajlm-801	19	21	had	have	VERB
ajlm-801	19	22	discordant	discordant	ADJ
ajlm-801	19	23	phenotypic	phenotypic	ADJ
ajlm-801	19	24	results	result	NOUN
ajlm-801	19	25	between	between	ADP
ajlm-801	19	26	initial	initial	ADJ
ajlm-801	19	27	and	and	CCONJ
ajlm-801	19	28	repeat	repeat	NOUN
ajlm-801	19	29	testing	testing	NOUN
ajlm-801	19	30	to	to	ADP
ajlm-801	19	31	either	either	CCONJ
ajlm-801	19	32	the	the	DET
ajlm-801	19	33	fluoroquinolones	fluoroquinolone	NOUN
ajlm-801	19	34	or	or	CCONJ
ajlm-801	19	35	pyrazinamide	pyrazinamide	NOUN
ajlm-801	19	36	.	.	PUNCT
ajlm-801	20	1	table	table	NOUN
ajlm-801	20	2	1	1	NUM
ajlm-801	20	3	:	:	PUNCT
ajlm-801	20	4	 	 	SPACE
ajlm-801	20	5	summary	summary	NOUN
ajlm-801	20	6	of	of	ADP
ajlm-801	20	7	performance	performance	NOUN
ajlm-801	20	8	for	for	ADP
ajlm-801	20	9	drug	drug	NOUN
ajlm-801	20	10	resistance	resistance	NOUN
ajlm-801	20	11	determination	determination	NOUN
ajlm-801	20	12	using	use	VERB
ajlm-801	20	13	the	the	DET
ajlm-801	20	14	mgit960	mgit960	PROPN
ajlm-801	20	15	,	,	PUNCT
ajlm-801	20	16	mtbdrplus	mtbdrplus	ADJ
ajlm-801	20	17	assay	assay	NOUN
ajlm-801	20	18	and	and	CCONJ
ajlm-801	20	19	whole	whole	ADJ
ajlm-801	20	20	genome	genome	NOUN
ajlm-801	20	21	sequencing	sequencing	NOUN
ajlm-801	20	22	.	.	PUNCT
ajlm-801	21	1	routine	routine	ADJ
ajlm-801	21	2	laboratory	laboratory	NOUN
ajlm-801	21	3	phenotypic	phenotypic	NOUN
ajlm-801	21	4	testing	testing	NOUN
ajlm-801	21	5	phenotypic	phenotypic	NOUN
ajlm-801	21	6	dst	dst	NOUN
ajlm-801	21	7	was	be	AUX
ajlm-801	21	8	performed	perform	VERB
ajlm-801	21	9	on	on	ADP
ajlm-801	21	10	the	the	DET
ajlm-801	21	11	bactec	bactec	ADJ
ajlm-801	21	12	mycobacterial	mycobacterial	ADJ
ajlm-801	21	13	growth	growth	NOUN
ajlm-801	21	14	indicator	indicator	NOUN
ajlm-801	21	15	tube	tube	NOUN
ajlm-801	21	16	(	(	PUNCT
ajlm-801	21	17	mgit	mgit	PROPN
ajlm-801	21	18	)	)	PUNCT
ajlm-801	21	19	960	960	NUM
ajlm-801	21	20	system	system	NOUN
ajlm-801	21	21	(	(	PUNCT
ajlm-801	21	22	becton	becton	PROPN
ajlm-801	21	23	dickinson	dickinson	PROPN
ajlm-801	21	24	diagnostic	diagnostic	PROPN
ajlm-801	21	25	systems	system	NOUN
ajlm-801	21	26	,	,	PUNCT
ajlm-801	21	27	sparks	spark	NOUN
ajlm-801	21	28	,	,	PUNCT
ajlm-801	21	29	maryland	maryland	PROPN
ajlm-801	21	30	,	,	PUNCT
ajlm-801	21	31	united	united	PROPN
ajlm-801	21	32	states	states	PROPN
ajlm-801	21	33	)	)	PUNCT
ajlm-801	21	34	following	follow	VERB
ajlm-801	21	35	the	the	DET
ajlm-801	21	36	manufacturer	manufacturer	NOUN
ajlm-801	21	37	’s	’s	PART
ajlm-801	21	38	recommendation	recommendation	NOUN
ajlm-801	21	39	.	.	PUNCT
ajlm-801	22	1	first	first	ADJ
ajlm-801	22	2	and	and	CCONJ
ajlm-801	22	3	second	second	ADJ
ajlm-801	22	4	-	-	PUNCT
ajlm-801	22	5	line	line	NOUN
ajlm-801	22	6	anti	anti	ADJ
ajlm-801	22	7	-	-	ADJ
ajlm-801	22	8	mycobacterial	mycobacterial	ADJ
ajlm-801	22	9	drugs	drug	NOUN
ajlm-801	22	10	(	(	PUNCT
ajlm-801	22	11	rifampicin	rifampicin	VERB
ajlm-801	22	12	,	,	PUNCT
ajlm-801	22	13	isoniazid	isoniazid	NOUN
ajlm-801	22	14	,	,	PUNCT
ajlm-801	22	15	ofloxacin	ofloxacin	PROPN
ajlm-801	22	16	,	,	PUNCT
ajlm-801	22	17	moxifloxacin	moxifloxacin	PRON
ajlm-801	22	18	,	,	PUNCT
ajlm-801	22	19	ptyrazinamide	ptyrazinamide	NOUN
ajlm-801	22	20	,	,	PUNCT
ajlm-801	22	21	amikacin	amikacin	PROPN
ajlm-801	22	22	,	,	PUNCT
ajlm-801	22	23	and	and	CCONJ
ajlm-801	22	24	kanamycin	kanamycin	NOUN
ajlm-801	22	25	)	)	PUNCT
ajlm-801	22	26	were	be	AUX
ajlm-801	22	27	tested	test	VERB
ajlm-801	22	28	following	follow	VERB
ajlm-801	22	29	the	the	PRON
ajlm-801	22	30	who	who	PRON
ajlm-801	22	31	2012	2012	NUM
ajlm-801	22	32	policy	policy	NOUN
ajlm-801	22	33	guidelines.14	guidelines.14	NOUN
ajlm-801	22	34	replicate	replicate	VERB
ajlm-801	22	35	testing	testing	NOUN
ajlm-801	22	36	was	be	AUX
ajlm-801	22	37	performed	perform	VERB
ajlm-801	22	38	on	on	ADP
ajlm-801	22	39	any	any	DET
ajlm-801	22	40	isolate	isolate	NOUN
ajlm-801	22	41	resistant	resistant	ADJ
ajlm-801	22	42	to	to	PART
ajlm-801	22	43	pyrazinamide	pyrazinamide	VERB
ajlm-801	22	44	or	or	CCONJ
ajlm-801	22	45	second	second	ADJ
ajlm-801	22	46	-	-	PUNCT
ajlm-801	22	47	line	line	NOUN
ajlm-801	22	48	drugs	drug	NOUN
ajlm-801	22	49	on	on	ADP
ajlm-801	22	50	initial	initial	ADJ
ajlm-801	22	51	testing	testing	NOUN
ajlm-801	22	52	.	.	PUNCT
ajlm-801	23	1	next	next	ADJ
ajlm-801	23	2	-	-	PUNCT
ajlm-801	23	3	generation	generation	NOUN
ajlm-801	23	4	sequencing	sequence	VERB
ajlm-801	23	5	wgs	wgs	NOUN
ajlm-801	23	6	was	be	AUX
ajlm-801	23	7	performed	perform	VERB
ajlm-801	23	8	using	use	VERB
ajlm-801	23	9	the	the	DET
ajlm-801	23	10	miseq	miseq	ADJ
ajlm-801	23	11	version	version	NOUN
ajlm-801	23	12	2	2	NUM
ajlm-801	23	13	kit	kit	NOUN
ajlm-801	23	14	(	(	PUNCT
ajlm-801	23	15	illumina	illumina	PROPN
ajlm-801	23	16	,	,	PUNCT
ajlm-801	23	17	san	san	PROPN
ajlm-801	23	18	diego	diego	PROPN
ajlm-801	23	19	,	,	PUNCT
ajlm-801	23	20	california	california	PROPN
ajlm-801	23	21	,	,	PUNCT
ajlm-801	23	22	united	united	PROPN
ajlm-801	23	23	states	states	PROPN
ajlm-801	23	24	)	)	PUNCT
ajlm-801	23	25	.	.	PUNCT
ajlm-801	24	1	in	in	ADP
ajlm-801	24	2	brief	brief	ADJ
ajlm-801	24	3	,	,	PUNCT
ajlm-801	24	4	dna	dna	PROPN
ajlm-801	24	5	was	be	AUX
ajlm-801	24	6	extracted	extract	VERB
ajlm-801	24	7	using	use	VERB
ajlm-801	24	8	the	the	DET
ajlm-801	24	9	nuclisens	nuclisen	NOUN
ajlm-801	24	10	easymag	easymag	NOUN
ajlm-801	24	11	system	system	NOUN
ajlm-801	24	12	(	(	PUNCT
ajlm-801	24	13	biomérieux	biomérieux	PROPN
ajlm-801	24	14	,	,	PUNCT
ajlm-801	24	15	marcy	marcy	NOUN
ajlm-801	24	16	-	-	PUNCT
ajlm-801	24	17	l’étoile	l’étoile	PROPN
ajlm-801	24	18	,	,	PUNCT
ajlm-801	24	19	france	france	PROPN
ajlm-801	24	20	)	)	PUNCT
ajlm-801	24	21	from	from	ADP
ajlm-801	24	22	a	a	DET
ajlm-801	24	23	200	200	NUM
ajlm-801	24	24	µl	µl	ADP
ajlm-801	24	25	aliquot	aliquot	NOUN
ajlm-801	24	26	of	of	ADP
ajlm-801	24	27	heatinactivated	heatinactivated	ADJ
ajlm-801	24	28	,	,	PUNCT
ajlm-801	24	29	mgit	mgit	ADJ
ajlm-801	24	30	-	-	PUNCT
ajlm-801	24	31	cultured	cultured	ADJ
ajlm-801	24	32	isolate	isolate	NOUN
ajlm-801	24	33	and	and	CCONJ
ajlm-801	24	34	concentrations	concentration	NOUN
ajlm-801	24	35	quantified	quantify	VERB
ajlm-801	24	36	using	use	VERB
ajlm-801	24	37	the	the	DET
ajlm-801	24	38	qubit	qubit	NOUN
ajlm-801	24	39	dsdna	dsdna	PROPN
ajlm-801	24	40	hs	hs	PROPN
ajlm-801	24	41	(	(	PUNCT
ajlm-801	24	42	high	high	ADJ
ajlm-801	24	43	sensitivity	sensitivity	NOUN
ajlm-801	24	44	)	)	PUNCT
ajlm-801	24	45	assay	assay	PROPN
ajlm-801	24	46	(	(	PUNCT
ajlm-801	24	47	life	life	NOUN
ajlm-801	24	48	technologies	technology	NOUN
ajlm-801	24	49	,	,	PUNCT
ajlm-801	24	50	carlsbad	carlsbad	PROPN
ajlm-801	24	51	,	,	PUNCT
ajlm-801	24	52	california	california	PROPN
ajlm-801	24	53	,	,	PUNCT
ajlm-801	24	54	united	united	PROPN
ajlm-801	24	55	states	states	PROPN
ajlm-801	24	56	)	)	PUNCT
ajlm-801	24	57	.	.	PUNCT
ajlm-801	25	1	libraries	library	NOUN
ajlm-801	25	2	were	be	AUX
ajlm-801	25	3	prepared	prepare	VERB
ajlm-801	25	4	using	use	VERB
ajlm-801	25	5	nextera	nextera	PROPN
ajlm-801	25	6	xt	xt	PROPN
ajlm-801	26	1	kit	kit	PROPN
ajlm-801	26	2	(	(	PUNCT
ajlm-801	26	3	illumina	illumina	PROPN
ajlm-801	26	4	,	,	PUNCT
ajlm-801	26	5	san	san	PROPN
ajlm-801	26	6	diego	diego	PROPN
ajlm-801	26	7	,	,	PUNCT
ajlm-801	26	8	california	california	PROPN
ajlm-801	26	9	,	,	PUNCT
ajlm-801	26	10	united	united	PROPN
ajlm-801	26	11	states	states	PROPN
ajlm-801	26	12	)	)	PUNCT
ajlm-801	26	13	following	follow	VERB
ajlm-801	26	14	the	the	DET
ajlm-801	26	15	manufacturers	manufacturer	NOUN
ajlm-801	26	16	’	’	PART
ajlm-801	26	17	protocol	protocol	NOUN
ajlm-801	26	18	with	with	ADP
ajlm-801	26	19	one	one	NUM
ajlm-801	26	20	modification	modification	NOUN
ajlm-801	26	21	(	(	PUNCT
ajlm-801	26	22	figure	figure	NOUN
ajlm-801	26	23	1	1	NUM
ajlm-801	26	24	)	)	PUNCT
ajlm-801	26	25	.	.	PUNCT
ajlm-801	27	1	the	the	DET
ajlm-801	27	2	modification	modification	NOUN
ajlm-801	27	3	deviated	deviate	VERB
ajlm-801	27	4	at	at	ADP
ajlm-801	27	5	the	the	DET
ajlm-801	27	6	normalisation	normalisation	NOUN
ajlm-801	27	7	step	step	NOUN
ajlm-801	27	8	,	,	PUNCT
ajlm-801	27	9	where	where	SCONJ
ajlm-801	27	10	the	the	DET
ajlm-801	27	11	indexed	indexed	ADJ
ajlm-801	27	12	dna	dna	PROPN
ajlm-801	27	13	libraries	library	NOUN
ajlm-801	27	14	concentrations	concentration	NOUN
ajlm-801	27	15	were	be	AUX
ajlm-801	27	16	quantified	quantify	VERB
ajlm-801	27	17	as	as	SCONJ
ajlm-801	27	18	described	describe	VERB
ajlm-801	27	19	above	above	ADV
ajlm-801	27	20	and	and	CCONJ
ajlm-801	27	21	normalised	normalise	VERB
ajlm-801	27	22	to	to	ADP
ajlm-801	27	23	4	4	NUM
ajlm-801	27	24	nm	nm	NOUN
ajlm-801	27	25	by	by	ADP
ajlm-801	27	26	addition	addition	NOUN
ajlm-801	27	27	of	of	ADP
ajlm-801	27	28	tris	tris	NOUN
ajlm-801	27	29	-	-	PUNCT
ajlm-801	27	30	cl	cl	NOUN
ajlm-801	27	31	(	(	PUNCT
ajlm-801	27	32	10	10	NUM
ajlm-801	27	33	nm	nm	NOUN
ajlm-801	27	34	,	,	PUNCT
ajlm-801	27	35	ph8.5	ph8.5	NUM
ajlm-801	27	36	with	with	ADP
ajlm-801	27	37	0.1	0.1	NUM
ajlm-801	27	38	%	%	NOUN
ajlm-801	27	39	tween20	tween20	NOUN
ajlm-801	27	40	)	)	PUNCT
ajlm-801	27	41	.	.	PUNCT
ajlm-801	28	1	thereafter	thereafter	ADV
ajlm-801	28	2	,	,	PUNCT
ajlm-801	28	3	the	the	DET
ajlm-801	28	4	indexed	index	VERB
ajlm-801	28	5	libraries	library	NOUN
ajlm-801	28	6	of	of	ADP
ajlm-801	28	7	all	all	DET
ajlm-801	28	8	20	20	NUM
ajlm-801	28	9	isolates	isolate	NOUN
ajlm-801	28	10	were	be	AUX
ajlm-801	28	11	pooled	pool	VERB
ajlm-801	28	12	to	to	ADP
ajlm-801	28	13	a	a	DET
ajlm-801	28	14	final	final	ADJ
ajlm-801	28	15	concentration	concentration	NOUN
ajlm-801	28	16	of	of	ADP
ajlm-801	28	17	12	12	NUM
ajlm-801	28	18	pm	pm	NOUN
ajlm-801	28	19	and	and	CCONJ
ajlm-801	28	20	loaded	load	VERB
ajlm-801	28	21	onto	onto	ADP
ajlm-801	28	22	the	the	DET
ajlm-801	28	23	miseq	miseq	NOUN
ajlm-801	28	24	for	for	ADP
ajlm-801	28	25	sequencing	sequence	VERB
ajlm-801	28	26	.	.	PUNCT
ajlm-801	29	1	figure	figure	NOUN
ajlm-801	29	2	1	1	NUM
ajlm-801	29	3	:	:	PUNCT
ajlm-801	29	4	operational	operational	ADJ
ajlm-801	29	5	workflow	workflow	NOUN
ajlm-801	29	6	for	for	ADP
ajlm-801	29	7	phenotypic	phenotypic	ADJ
ajlm-801	29	8	drug	drug	NOUN
ajlm-801	29	9	resistance	resistance	NOUN
ajlm-801	29	10	determination	determination	NOUN
ajlm-801	29	11	versus	versus	ADP
ajlm-801	29	12	resistance	resistance	NOUN
ajlm-801	29	13	prediction	prediction	NOUN
ajlm-801	29	14	by	by	ADP
ajlm-801	29	15	whole	whole	ADJ
ajlm-801	29	16	genome	genome	NOUN
ajlm-801	29	17	sequencing	sequencing	NOUN
ajlm-801	29	18	.	.	PUNCT
ajlm-801	30	1	the	the	DET
ajlm-801	30	2	batch	batch	NOUN
ajlm-801	30	3	size	size	NOUN
ajlm-801	30	4	is	be	AUX
ajlm-801	30	5	calculated	calculate	VERB
ajlm-801	30	6	at	at	ADP
ajlm-801	30	7	20	20	NUM
ajlm-801	30	8	isolates	isolate	NOUN
ajlm-801	30	9	[	[	X
ajlm-801	30	10	estimated	estimate	VERB
ajlm-801	30	11	hands	hand	NOUN
ajlm-801	30	12	-	-	PUNCT
ajlm-801	30	13	on	on	ADP
ajlm-801	30	14	time	time	NOUN
ajlm-801	30	15	]	]	PUNCT
ajlm-801	30	16	.	.	PUNCT
ajlm-801	31	1	bioinformatic	bioinformatic	ADJ
ajlm-801	31	2	analysis	analysis	NOUN
ajlm-801	31	3	of	of	ADP
ajlm-801	31	4	wgs	wgs	NOUN
ajlm-801	31	5	data	data	PROPN
ajlm-801	31	6	clc	clc	PROPN
ajlm-801	31	7	genomics	genomics	PROPN
ajlm-801	31	8	workbench	workbench	VERB
ajlm-801	31	9	version	version	NOUN
ajlm-801	31	10	6.0.1	6.0.1	NUM
ajlm-801	31	11	(	(	PUNCT
ajlm-801	31	12	qiagen	qiagen	PROPN
ajlm-801	31	13	,	,	PUNCT
ajlm-801	31	14	venlo	venlo	PROPN
ajlm-801	31	15	,	,	PUNCT
ajlm-801	31	16	the	the	DET
ajlm-801	31	17	netherlands	netherlands	PROPN
ajlm-801	31	18	)	)	PUNCT
ajlm-801	31	19	was	be	AUX
ajlm-801	31	20	used	use	VERB
ajlm-801	31	21	for	for	ADP
ajlm-801	31	22	bioinformatic	bioinformatic	ADJ
ajlm-801	31	23	analysis	analysis	NOUN
ajlm-801	31	24	.	.	PUNCT
ajlm-801	32	1	variant	variant	ADJ
ajlm-801	32	2	tables	table	NOUN
ajlm-801	32	3	for	for	ADP
ajlm-801	32	4	genetic	genetic	ADJ
ajlm-801	32	5	targets	target	NOUN
ajlm-801	32	6	associated	associate	VERB
ajlm-801	32	7	with	with	ADP
ajlm-801	32	8	resistance	resistance	NOUN
ajlm-801	32	9	to	to	ADP
ajlm-801	32	10	rifampicin	rifampicin	PROPN
ajlm-801	32	11	,	,	PUNCT
ajlm-801	32	12	isoniazid	isoniazid	NOUN
ajlm-801	32	13	,	,	PUNCT
ajlm-801	32	14	fluoroquinolones	fluoroquinolone	NOUN
ajlm-801	32	15	(	(	PUNCT
ajlm-801	32	16	ofloxacin	ofloxacin	NOUN
ajlm-801	32	17	and	and	CCONJ
ajlm-801	32	18	moxifloxacin	moxifloxacin	NOUN
ajlm-801	32	19	)	)	PUNCT
ajlm-801	32	20	,	,	PUNCT
ajlm-801	32	21	pyrazinamide	pyrazinamide	ADV
ajlm-801	32	22	,	,	PUNCT
ajlm-801	32	23	aminoglycosides	aminoglycoside	NOUN
ajlm-801	32	24	(	(	PUNCT
ajlm-801	32	25	amikacin	amikacin	PROPN
ajlm-801	32	26	and	and	CCONJ
ajlm-801	32	27	kanamycin	kanamycin	NOUN
ajlm-801	32	28	)	)	PUNCT
ajlm-801	32	29	,	,	PUNCT
ajlm-801	32	30	bedaquiline	bedaquiline	NOUN
ajlm-801	32	31	and	and	CCONJ
ajlm-801	32	32	delamanid	delamanid	ADJ
ajlm-801	32	33	(	(	PUNCT
ajlm-801	32	34	table	table	NOUN
ajlm-801	32	35	2	2	NUM
ajlm-801	32	36	)	)	PUNCT
ajlm-801	32	37	were	be	AUX
ajlm-801	32	38	generated	generate	VERB
ajlm-801	32	39	using	use	VERB
ajlm-801	32	40	the	the	DET
ajlm-801	32	41	map	map	NOUN
ajlm-801	32	42	reads	read	VERB
ajlm-801	32	43	to	to	PART
ajlm-801	32	44	reference	reference	VERB
ajlm-801	32	45	tool	tool	NOUN
ajlm-801	32	46	and	and	CCONJ
ajlm-801	32	47	quality	quality	NOUN
ajlm-801	32	48	-	-	PUNCT
ajlm-801	32	49	based	base	VERB
ajlm-801	32	50	variant	variant	ADJ
ajlm-801	32	51	detection	detection	NOUN
ajlm-801	32	52	algorithm	algorithm	NOUN
ajlm-801	32	53	on	on	ADP
ajlm-801	32	54	clc	clc	PROPN
ajlm-801	32	55	genomics	genomics	NOUN
ajlm-801	32	56	workbench	workbench	NOUN
ajlm-801	32	57	using	use	VERB
ajlm-801	32	58	the	the	DET
ajlm-801	32	59	h37rv	h37rv	PROPN
ajlm-801	32	60	sanger	sanger	PROPN
ajlm-801	32	61	reference	reference	NOUN
ajlm-801	32	62	genome	genome	NOUN
ajlm-801	32	63	(	(	PUNCT
ajlm-801	32	64	genbank	genbank	NOUN
ajlm-801	32	65	nc000962.3	nc000962.3	NUM
ajlm-801	32	66	)	)	PUNCT
ajlm-801	32	67	.	.	PUNCT
ajlm-801	33	1	the	the	DET
ajlm-801	33	2	following	follow	VERB
ajlm-801	33	3	cut	cut	NOUN
ajlm-801	33	4	-	-	PUNCT
ajlm-801	33	5	offs	off	NOUN
ajlm-801	33	6	were	be	AUX
ajlm-801	33	7	applied	apply	VERB
ajlm-801	33	8	to	to	PART
ajlm-801	33	9	call	call	VERB
ajlm-801	33	10	a	a	DET
ajlm-801	33	11	single	single	ADJ
ajlm-801	33	12	nucleotide	nucleotide	ADJ
ajlm-801	33	13	polymorphism	polymorphism	NOUN
ajlm-801	33	14	or	or	CCONJ
ajlm-801	33	15	insertion	insertion	NOUN
ajlm-801	33	16	/	/	SYM
ajlm-801	33	17	deletion	deletion	NOUN
ajlm-801	33	18	:	:	PUNCT
ajlm-801	33	19	a	a	DET
ajlm-801	33	20	minimum	minimum	ADJ
ajlm-801	33	21	paired	pair	VERB
ajlm-801	33	22	coverage	coverage	NOUN
ajlm-801	33	23	depth	depth	NOUN
ajlm-801	33	24	of	of	ADP
ajlm-801	33	25	five	five	NUM
ajlm-801	33	26	times	time	NOUN
ajlm-801	33	27	(	(	PUNCT
ajlm-801	33	28	5×	5×	PROPN
ajlm-801	33	29	)	)	PUNCT
ajlm-801	33	30	,	,	PUNCT
ajlm-801	33	31	frequency	frequency	NOUN
ajlm-801	33	32	of	of	ADP
ajlm-801	33	33	>	>	X
ajlm-801	33	34	70	70	NUM
ajlm-801	33	35	%	%	NOUN
ajlm-801	33	36	and	and	CCONJ
ajlm-801	33	37	a	a	DET
ajlm-801	33	38	phil	phil	NOUN
ajlm-801	33	39	’s	’s	PART
ajlm-801	33	40	read	read	PROPN
ajlm-801	33	41	editor	editor	NOUN
ajlm-801	33	42	,	,	PUNCT
ajlm-801	33	43	or	or	CCONJ
ajlm-801	33	44	phred	phre	VERB
ajlm-801	33	45	,	,	PUNCT
ajlm-801	33	46	quality	quality	NOUN
ajlm-801	33	47	score	score	NOUN
ajlm-801	33	48	of	of	ADP
ajlm-801	33	49	≥	≥	NOUN
ajlm-801	33	50	q20	q20	NOUN
ajlm-801	33	51	(	(	PUNCT
ajlm-801	33	52	≥	≥	NUM
ajlm-801	33	53	99	99	NUM
ajlm-801	33	54	%	%	NOUN
ajlm-801	33	55	accuracy	accuracy	NOUN
ajlm-801	33	56	)	)	PUNCT
ajlm-801	33	57	at	at	ADP
ajlm-801	33	58	the	the	DET
ajlm-801	33	59	variant	variant	ADJ
ajlm-801	33	60	position	position	NOUN
ajlm-801	33	61	and	and	CCONJ
ajlm-801	33	62	neighbouring	neighbouring	ADJ
ajlm-801	33	63	nucleotides	nucleotide	NOUN
ajlm-801	33	64	within	within	ADP
ajlm-801	33	65	a	a	DET
ajlm-801	33	66	radius	radius	NOUN
ajlm-801	33	67	of	of	ADP
ajlm-801	33	68	five	five	NUM
ajlm-801	33	69	base	base	NOUN
ajlm-801	33	70	pairs	pair	NOUN
ajlm-801	33	71	.	.	PUNCT
ajlm-801	34	1	to	to	PART
ajlm-801	34	2	ensure	ensure	VERB
ajlm-801	34	3	that	that	SCONJ
ajlm-801	34	4	an	an	DET
ajlm-801	34	5	isolate	isolate	NOUN
ajlm-801	34	6	was	be	AUX
ajlm-801	34	7	truly	truly	ADV
ajlm-801	34	8	wild	wild	ADJ
ajlm-801	34	9	-	-	PUNCT
ajlm-801	34	10	type	type	NOUN
ajlm-801	34	11	for	for	ADP
ajlm-801	34	12	a	a	DET
ajlm-801	34	13	specific	specific	ADJ
ajlm-801	34	14	gene	gene	NOUN
ajlm-801	34	15	target	target	NOUN
ajlm-801	34	16	,	,	PUNCT
ajlm-801	34	17	we	we	PRON
ajlm-801	34	18	further	far	ADV
ajlm-801	34	19	ran	run	VERB
ajlm-801	34	20	the	the	DET
ajlm-801	34	21	create	create	NOUN
ajlm-801	34	22	statistics	statistic	NOUN
ajlm-801	34	23	for	for	ADP
ajlm-801	34	24	target	target	NOUN
ajlm-801	34	25	regions	region	NOUN
ajlm-801	34	26	on	on	ADP
ajlm-801	34	27	clc	clc	PROPN
ajlm-801	34	28	genomics	genomics	NOUN
ajlm-801	34	29	workbench	workbench	NOUN
ajlm-801	34	30	to	to	PART
ajlm-801	34	31	ensure	ensure	VERB
ajlm-801	34	32	that	that	SCONJ
ajlm-801	34	33	the	the	DET
ajlm-801	34	34	entire	entire	ADJ
ajlm-801	34	35	length	length	NOUN
ajlm-801	34	36	of	of	ADP
ajlm-801	34	37	the	the	DET
ajlm-801	34	38	gene	gene	NOUN
ajlm-801	34	39	investigated	investigate	VERB
ajlm-801	34	40	was	be	AUX
ajlm-801	34	41	completely	completely	ADV
ajlm-801	34	42	sequenced	sequence	VERB
ajlm-801	34	43	.	.	PUNCT
ajlm-801	35	1	since	since	SCONJ
ajlm-801	35	2	no	no	DET
ajlm-801	35	3	thresholds	threshold	NOUN
ajlm-801	35	4	have	have	AUX
ajlm-801	35	5	been	be	AUX
ajlm-801	35	6	formally	formally	ADV
ajlm-801	35	7	established	establish	VERB
ajlm-801	35	8	for	for	ADP
ajlm-801	35	9	bioinformatic	bioinformatic	ADJ
ajlm-801	35	10	analysis	analysis	NOUN
ajlm-801	35	11	,	,	PUNCT
ajlm-801	35	12	we	we	PRON
ajlm-801	35	13	utilised	utilise	VERB
ajlm-801	35	14	less	less	ADV
ajlm-801	35	15	stringent	stringent	ADJ
ajlm-801	35	16	parameters	parameter	NOUN
ajlm-801	35	17	than	than	ADP
ajlm-801	35	18	those	those	DET
ajlm-801	35	19	previously	previously	ADV
ajlm-801	35	20	described.15	described.15	ADJ
ajlm-801	35	21	table	table	NOUN
ajlm-801	35	22	2	2	NUM
ajlm-801	35	23	:	:	PUNCT
ajlm-801	35	24	 	 	SPACE
ajlm-801	35	25	table	table	NOUN
ajlm-801	35	26	detailing	detail	VERB
ajlm-801	35	27	first	first	ADJ
ajlm-801	35	28	-	-	PUNCT
ajlm-801	35	29	line	line	NOUN
ajlm-801	35	30	,	,	PUNCT
ajlm-801	35	31	second	second	ADJ
ajlm-801	35	32	-	-	PUNCT
ajlm-801	35	33	line	line	NOUN
ajlm-801	35	34	and	and	CCONJ
ajlm-801	35	35	novel	novel	ADJ
ajlm-801	35	36	tuberculosis	tuberculosis	NOUN
ajlm-801	35	37	drugs	drug	NOUN
ajlm-801	35	38	,	,	PUNCT
ajlm-801	35	39	their	their	PRON
ajlm-801	35	40	resistance	resistance	NOUN
ajlm-801	35	41	-	-	PUNCT
ajlm-801	35	42	associated	associate	VERB
ajlm-801	35	43	genes	gene	NOUN
ajlm-801	35	44	and	and	CCONJ
ajlm-801	35	45	their	their	PRON
ajlm-801	35	46	length	length	NOUN
ajlm-801	35	47	.	.	PUNCT
ajlm-801	36	1	association	association	NOUN
ajlm-801	36	2	of	of	ADP
ajlm-801	36	3	mutations	mutation	NOUN
ajlm-801	36	4	as	as	SCONJ
ajlm-801	36	5	resistance	resistance	NOUN
ajlm-801	36	6	predictors	predictor	NOUN
ajlm-801	36	7	were	be	AUX
ajlm-801	36	8	identified	identify	VERB
ajlm-801	36	9	using	use	VERB
ajlm-801	36	10	the	the	DET
ajlm-801	36	11	tb	tb	NOUN
ajlm-801	36	12	drug	drug	NOUN
ajlm-801	36	13	resistance	resistance	NOUN
ajlm-801	36	14	mutation	mutation	NOUN
ajlm-801	36	15	database	database	NOUN
ajlm-801	36	16	(	(	PUNCT
ajlm-801	36	17	tbdreamdb	tbdreamdb	NOUN
ajlm-801	36	18	)	)	PUNCT
ajlm-801	36	19	database16	database16	NOUN
ajlm-801	36	20	primarily	primarily	ADV
ajlm-801	36	21	.	.	PUNCT
ajlm-801	37	1	if	if	SCONJ
ajlm-801	37	2	a	a	DET
ajlm-801	37	3	mutation	mutation	NOUN
ajlm-801	37	4	was	be	AUX
ajlm-801	37	5	not	not	PART
ajlm-801	37	6	listed	list	VERB
ajlm-801	37	7	,	,	PUNCT
ajlm-801	37	8	literature	literature	NOUN
ajlm-801	37	9	,	,	PUNCT
ajlm-801	37	10	including	include	VERB
ajlm-801	37	11	newer	new	ADJ
ajlm-801	37	12	published	publish	VERB
ajlm-801	37	13	databases	database	NOUN
ajlm-801	37	14	such	such	ADJ
ajlm-801	37	15	as	as	ADP
ajlm-801	37	16	tbprofiler	tbprofiler	NOUN
ajlm-801	37	17	and	and	CCONJ
ajlm-801	37	18	phyresse	phyresse	NOUN
ajlm-801	37	19	,	,	PUNCT
ajlm-801	37	20	was	be	AUX
ajlm-801	37	21	surveyed	survey	VERB
ajlm-801	37	22	to	to	PART
ajlm-801	37	23	identify	identify	VERB
ajlm-801	37	24	the	the	DET
ajlm-801	37	25	association.17,18	association.17,18	NOUN
ajlm-801	37	26	putative	putative	ADJ
ajlm-801	37	27	mutations	mutation	NOUN
ajlm-801	37	28	associated	associate	VERB
ajlm-801	37	29	with	with	ADP
ajlm-801	37	30	the	the	DET
ajlm-801	37	31	novel	novel	ADJ
ajlm-801	37	32	drugs	drug	NOUN
ajlm-801	37	33	bedaquiline	bedaquiline	NOUN
ajlm-801	37	34	and	and	CCONJ
ajlm-801	37	35	delamanid	delamanid	PROPN
ajlm-801	37	36	were	be	AUX
ajlm-801	37	37	exclusively	exclusively	ADV
ajlm-801	37	38	identified	identify	VERB
ajlm-801	37	39	using	use	VERB
ajlm-801	37	40	published	publish	VERB
ajlm-801	37	41	literature.11,19	literature.11,19	NOUN
ajlm-801	37	42	the	the	DET
ajlm-801	37	43	rpob	rpob	PROPN
ajlm-801	37	44	-	-	PUNCT
ajlm-801	37	45	associated	associate	VERB
ajlm-801	37	46	mutations	mutation	NOUN
ajlm-801	37	47	were	be	AUX
ajlm-801	37	48	converted	convert	VERB
ajlm-801	37	49	to	to	ADP
ajlm-801	37	50	the	the	DET
ajlm-801	37	51	widely	widely	ADV
ajlm-801	37	52	used	use	VERB
ajlm-801	37	53	escherichia	escherichia	NOUN
ajlm-801	37	54	coli	coli	NOUN
ajlm-801	37	55	nomenclature	nomenclature	NOUN
ajlm-801	37	56	(	(	PUNCT
ajlm-801	37	57	addition	addition	NOUN
ajlm-801	37	58	of	of	ADP
ajlm-801	37	59	81	81	NUM
ajlm-801	37	60	codon	codon	ADJ
ajlm-801	37	61	positions).20	positions).20	PROPN
ajlm-801	37	62	resolving	resolve	VERB
ajlm-801	37	63	discordant	discordant	ADJ
ajlm-801	37	64	phenotypic	phenotypic	NOUN
ajlm-801	37	65	and	and	CCONJ
ajlm-801	37	66	wgs	wgs	NOUN
ajlm-801	37	67	results	result	NOUN
ajlm-801	37	68	discordant	discordant	ADJ
ajlm-801	37	69	results	result	NOUN
ajlm-801	37	70	were	be	AUX
ajlm-801	37	71	resolved	resolve	VERB
ajlm-801	37	72	using	use	VERB
ajlm-801	37	73	the	the	DET
ajlm-801	37	74	minimum	minimum	ADJ
ajlm-801	37	75	inhibitory	inhibitory	ADJ
ajlm-801	37	76	concentration	concentration	NOUN
ajlm-801	37	77	broth	broth	NOUN
ajlm-801	37	78	microdilution	microdilution	NOUN
ajlm-801	37	79	method	method	NOUN
ajlm-801	37	80	(	(	PUNCT
ajlm-801	37	81	trek	trek	NOUN
ajlm-801	37	82	sensititre	sensititre	NOUN
ajlm-801	37	83	,	,	PUNCT
ajlm-801	37	84	thermofisher	thermofisher	PROPN
ajlm-801	37	85	,	,	PUNCT
ajlm-801	37	86	waltham	waltham	PROPN
ajlm-801	37	87	,	,	PUNCT
ajlm-801	37	88	massachusetts	massachusetts	PROPN
ajlm-801	37	89	,	,	PUNCT
ajlm-801	37	90	united	united	PROPN
ajlm-801	37	91	states	states	PROPN
ajlm-801	37	92	)	)	PUNCT
ajlm-801	37	93	and	and	CCONJ
ajlm-801	37	94	interpreted	interpret	VERB
ajlm-801	37	95	using	use	VERB
ajlm-801	37	96	the	the	DET
ajlm-801	37	97	critical	critical	ADJ
ajlm-801	37	98	concentrations	concentration	NOUN
ajlm-801	37	99	established	establish	VERB
ajlm-801	37	100	by	by	ADP
ajlm-801	37	101	hall	hall	PROPN
ajlm-801	37	102	et	et	PROPN
ajlm-801	37	103	al	al	PROPN
ajlm-801	37	104	.	.	PUNCT
ajlm-801	38	1	(	(	PUNCT
ajlm-801	38	2	2012).21	2012).21	PROPN
ajlm-801	38	3	in	in	ADP
ajlm-801	38	4	the	the	DET
ajlm-801	38	5	case	case	NOUN
ajlm-801	38	6	of	of	ADP
ajlm-801	38	7	pyrazinamide	pyrazinamide	NOUN
ajlm-801	38	8	,	,	PUNCT
ajlm-801	38	9	the	the	DET
ajlm-801	38	10	modified	modified	PROPN
ajlm-801	38	11	wayne	wayne	PROPN
ajlm-801	38	12	’s	’s	PART
ajlm-801	38	13	test22	test22	PROPN
ajlm-801	38	14	was	be	AUX
ajlm-801	38	15	used	use	VERB
ajlm-801	38	16	to	to	PART
ajlm-801	38	17	resolve	resolve	VERB
ajlm-801	38	18	discordance	discordance	NOUN
ajlm-801	38	19	.	.	PUNCT
ajlm-801	39	1	additionally	additionally	ADV
ajlm-801	39	2	,	,	PUNCT
ajlm-801	39	3	the	the	DET
ajlm-801	39	4	genotype	genotype	NOUN
ajlm-801	39	5	mtbdrplus	mtbdrplus	NOUN
ajlm-801	39	6	assay	assay	ADJ
ajlm-801	39	7	version	version	NOUN
ajlm-801	39	8	2	2	NUM
ajlm-801	39	9	(	(	PUNCT
ajlm-801	39	10	mtbdrplus	mtbdrplus	ADJ
ajlm-801	39	11	)	)	PUNCT
ajlm-801	39	12	(	(	PUNCT
ajlm-801	39	13	hain	hain	PROPN
ajlm-801	39	14	lifesciences	lifescience	NOUN
ajlm-801	39	15	,	,	PUNCT
ajlm-801	39	16	nehren	nehren	NOUN
ajlm-801	39	17	,	,	PUNCT
ajlm-801	39	18	germany	germany	PROPN
ajlm-801	39	19	)	)	PUNCT
ajlm-801	39	20	line	line	NOUN
ajlm-801	39	21	probe	probe	NOUN
ajlm-801	39	22	assay	assay	PROPN
ajlm-801	39	23	was	be	AUX
ajlm-801	39	24	performed	perform	VERB
ajlm-801	39	25	according	accord	VERB
ajlm-801	39	26	to	to	ADP
ajlm-801	39	27	the	the	DET
ajlm-801	39	28	manufacturer	manufacturer	NOUN
ajlm-801	39	29	’s	’s	PART
ajlm-801	39	30	instruction	instruction	NOUN
ajlm-801	39	31	for	for	ADP
ajlm-801	39	32	the	the	DET
ajlm-801	39	33	first	first	ADJ
ajlm-801	39	34	-	-	PUNCT
ajlm-801	39	35	line	line	NOUN
ajlm-801	39	36	drugs	drug	NOUN
ajlm-801	39	37	rifampicin	rifampicin	VERB
ajlm-801	39	38	and	and	CCONJ
ajlm-801	39	39	isoniazid	isoniazid	NOUN
ajlm-801	39	40	on	on	ADP
ajlm-801	39	41	all	all	DET
ajlm-801	39	42	isolates	isolate	NOUN
ajlm-801	39	43	.	.	PUNCT
ajlm-801	40	1	figure	figure	NOUN
ajlm-801	40	2	1	1	NUM
ajlm-801	40	3	provides	provide	VERB
ajlm-801	40	4	an	an	DET
ajlm-801	40	5	overview	overview	NOUN
ajlm-801	40	6	of	of	ADP
ajlm-801	40	7	the	the	DET
ajlm-801	40	8	operational	operational	ADJ
ajlm-801	40	9	workflow	workflow	NOUN
ajlm-801	40	10	for	for	ADP
ajlm-801	40	11	this	this	DET
ajlm-801	40	12	study	study	NOUN
ajlm-801	40	13	.	.	PUNCT
ajlm-801	41	1	results	result	NOUN
ajlm-801	41	2	concordance	concordance	NOUN
ajlm-801	41	3	between	between	ADP
ajlm-801	41	4	wgs	wgs	NOUN
ajlm-801	41	5	and	and	CCONJ
ajlm-801	41	6	the	the	DET
ajlm-801	41	7	phenotypic	phenotypic	ADJ
ajlm-801	41	8	dst	dst	NOUN
ajlm-801	41	9	method	method	NOUN
ajlm-801	41	10	for	for	ADP
ajlm-801	41	11	resistance	resistance	NOUN
ajlm-801	41	12	determination	determination	NOUN
ajlm-801	41	13	was	be	AUX
ajlm-801	41	14	noted	note	VERB
ajlm-801	41	15	for	for	ADP
ajlm-801	41	16	all	all	DET
ajlm-801	41	17	isolates	isolate	NOUN
ajlm-801	41	18	except	except	SCONJ
ajlm-801	41	19	one	one	NUM
ajlm-801	41	20	phenotypically	phenotypically	ADV
ajlm-801	41	21	susceptible	susceptible	ADJ
ajlm-801	41	22	isolate	isolate	NOUN
ajlm-801	41	23	for	for	ADP
ajlm-801	41	24	all	all	DET
ajlm-801	41	25	targets	target	NOUN
ajlm-801	41	26	explored	explore	VERB
ajlm-801	41	27	(	(	PUNCT
ajlm-801	41	28	table	table	NOUN
ajlm-801	41	29	1	1	NUM
ajlm-801	41	30	and	and	CCONJ
ajlm-801	41	31	table	table	NOUN
ajlm-801	41	32	2	2	NUM
ajlm-801	41	33	)	)	PUNCT
ajlm-801	41	34	.	.	PUNCT
ajlm-801	42	1	the	the	DET
ajlm-801	42	2	phenotypically	phenotypically	ADV
ajlm-801	42	3	susceptible	susceptible	ADJ
ajlm-801	42	4	isolate	isolate	NOUN
ajlm-801	42	5	harboured	harbour	VERB
ajlm-801	42	6	a	a	DET
ajlm-801	42	7	known	know	VERB
ajlm-801	42	8	resistance	resistance	NOUN
ajlm-801	42	9	associated	associate	VERB
ajlm-801	42	10	mutation	mutation	NOUN
ajlm-801	42	11	in	in	ADP
ajlm-801	42	12	the	the	DET
ajlm-801	42	13	fabg1	fabg1	NOUN
ajlm-801	42	14	/	/	SYM
ajlm-801	42	15	maba	maba	PROPN
ajlm-801	42	16	(	(	PUNCT
ajlm-801	42	17	inha	inha	NOUN
ajlm-801	42	18	promoter	promoter	NOUN
ajlm-801	42	19	)	)	PUNCT
ajlm-801	42	20	region	region	NOUN
ajlm-801	42	21	(	(	PUNCT
ajlm-801	42	22	inha	inha	NOUN
ajlm-801	42	23	promoter	promoter	NOUN
ajlm-801	42	24	c-15	c-15	PROPN
ajlm-801	42	25	t	t	PROPN
ajlm-801	42	26	)	)	PUNCT
ajlm-801	42	27	detected	detect	VERB
ajlm-801	42	28	by	by	ADP
ajlm-801	42	29	wgs	wgs	NOUN
ajlm-801	42	30	.	.	PUNCT
ajlm-801	43	1	this	this	DET
ajlm-801	43	2	finding	finding	NOUN
ajlm-801	43	3	was	be	AUX
ajlm-801	43	4	confirmed	confirm	VERB
ajlm-801	43	5	by	by	ADP
ajlm-801	43	6	the	the	DET
ajlm-801	43	7	mtbdrplus	mtbdrplus	ADJ
ajlm-801	43	8	assay	assay	NOUN
ajlm-801	43	9	displaying	display	VERB
ajlm-801	43	10	an	an	DET
ajlm-801	43	11	inhamut1	inhamut1	NOUN
ajlm-801	43	12	mutation	mutation	NOUN
ajlm-801	43	13	,	,	PUNCT
ajlm-801	43	14	and	and	CCONJ
ajlm-801	43	15	resistance	resistance	NOUN
ajlm-801	43	16	was	be	AUX
ajlm-801	43	17	confirmed	confirm	VERB
ajlm-801	43	18	by	by	ADP
ajlm-801	43	19	the	the	DET
ajlm-801	43	20	broth	broth	NOUN
ajlm-801	43	21	microdilution	microdilution	NOUN
ajlm-801	43	22	assay	assay	NOUN
ajlm-801	43	23	(	(	PUNCT
ajlm-801	43	24	minimum	minimum	ADJ
ajlm-801	43	25	inhibitory	inhibitory	ADJ
ajlm-801	43	26	concentration	concentration	NOUN
ajlm-801	43	27	of	of	ADP
ajlm-801	43	28	0.25	0.25	NUM
ajlm-801	43	29	µg	µg	NOUN
ajlm-801	43	30	/	/	SYM
ajlm-801	43	31	ml	ml	NOUN
ajlm-801	43	32	)	)	PUNCT
ajlm-801	43	33	(	(	PUNCT
ajlm-801	43	34	table	table	NOUN
ajlm-801	43	35	2	2	NUM
ajlm-801	43	36	)	)	PUNCT
ajlm-801	43	37	.	.	PUNCT
ajlm-801	44	1	interestingly	interestingly	ADV
ajlm-801	44	2	,	,	PUNCT
ajlm-801	44	3	we	we	PRON
ajlm-801	44	4	found	find	VERB
ajlm-801	44	5	that	that	SCONJ
ajlm-801	44	6	a	a	DET
ajlm-801	44	7	multidrug	multidrug	NOUN
ajlm-801	44	8	resistant	resistant	ADJ
ajlm-801	44	9	isolate	isolate	NOUN
ajlm-801	44	10	was	be	AUX
ajlm-801	44	11	incorrectly	incorrectly	ADV
ajlm-801	44	12	classified	classify	VERB
ajlm-801	44	13	as	as	ADP
ajlm-801	44	14	susceptible	susceptible	ADJ
ajlm-801	44	15	to	to	ADP
ajlm-801	44	16	rifampicin	rifampicin	VERB
ajlm-801	44	17	by	by	ADP
ajlm-801	44	18	the	the	DET
ajlm-801	44	19	mtbdrplus	mtbdrplus	ADJ
ajlm-801	44	20	assay	assay	NOUN
ajlm-801	44	21	and	and	CCONJ
ajlm-801	44	22	resistant	resistant	ADJ
ajlm-801	44	23	by	by	ADP
ajlm-801	44	24	both	both	DET
ajlm-801	44	25	mgit	mgit	PROPN
ajlm-801	44	26	dst	dst	PROPN
ajlm-801	44	27	and	and	CCONJ
ajlm-801	44	28	wgs	wgs	NOUN
ajlm-801	44	29	;	;	PUNCT
ajlm-801	44	30	the	the	DET
ajlm-801	44	31	latter	latter	ADJ
ajlm-801	44	32	detected	detect	VERB
ajlm-801	44	33	the	the	DET
ajlm-801	44	34	presence	presence	NOUN
ajlm-801	44	35	of	of	ADP
ajlm-801	44	36	the	the	DET
ajlm-801	44	37	rpobl511p	rpobl511p	NOUN
ajlm-801	44	38	mutation	mutation	NOUN
ajlm-801	44	39	,	,	PUNCT
ajlm-801	44	40	a	a	DET
ajlm-801	44	41	known	know	VERB
ajlm-801	44	42	rifampicin	rifampicin	VERB
ajlm-801	44	43	resistance	resistance	NOUN
ajlm-801	44	44	determinant	determinant	ADJ
ajlm-801	44	45	.	.	PUNCT
ajlm-801	45	1	three	three	NUM
ajlm-801	45	2	phenotypic	phenotypic	ADJ
ajlm-801	45	3	discordant	discordant	ADJ
ajlm-801	45	4	pyrazinamide	pyrazinamide	NOUN
ajlm-801	45	5	isolates	isolate	NOUN
ajlm-801	45	6	included	include	VERB
ajlm-801	45	7	were	be	AUX
ajlm-801	45	8	susceptible	susceptible	ADJ
ajlm-801	45	9	by	by	ADP
ajlm-801	45	10	wgs	wgs	NOUN
ajlm-801	45	11	and	and	CCONJ
ajlm-801	45	12	susceptibility	susceptibility	NOUN
ajlm-801	45	13	was	be	AUX
ajlm-801	45	14	confirmed	confirm	VERB
ajlm-801	45	15	by	by	ADP
ajlm-801	45	16	the	the	DET
ajlm-801	45	17	modified	modified	PROPN
ajlm-801	45	18	wayne	wayne	PROPN
ajlm-801	45	19	’s	’s	PART
ajlm-801	45	20	test	test	NOUN
ajlm-801	45	21	.	.	PUNCT
ajlm-801	46	1	of	of	ADP
ajlm-801	46	2	note	note	NOUN
ajlm-801	46	3	was	be	AUX
ajlm-801	46	4	the	the	DET
ajlm-801	46	5	finding	finding	NOUN
ajlm-801	46	6	that	that	SCONJ
ajlm-801	46	7	one	one	NUM
ajlm-801	46	8	isolate	isolate	NOUN
ajlm-801	46	9	had	have	AUX
ajlm-801	46	10	a	a	DET
ajlm-801	46	11	pncathr114met	pncathr114met	ADJ
ajlm-801	46	12	mutation	mutation	NOUN
ajlm-801	46	13	by	by	ADP
ajlm-801	46	14	wgs	wgs	NOUN
ajlm-801	46	15	that	that	PRON
ajlm-801	46	16	was	be	AUX
ajlm-801	46	17	not	not	PART
ajlm-801	46	18	listed	list	VERB
ajlm-801	46	19	in	in	ADP
ajlm-801	46	20	the	the	DET
ajlm-801	46	21	tbdreamdb	tbdreamdb	NOUN
ajlm-801	46	22	database	database	NOUN
ajlm-801	46	23	,	,	PUNCT
ajlm-801	46	24	and	and	CCONJ
ajlm-801	46	25	literature	literature	NOUN
ajlm-801	46	26	confirmed	confirm	VERB
ajlm-801	46	27	this	this	PRON
ajlm-801	46	28	not	not	PART
ajlm-801	46	29	to	to	PART
ajlm-801	46	30	be	be	AUX
ajlm-801	46	31	associated	associate	VERB
ajlm-801	46	32	with	with	ADP
ajlm-801	46	33	resistance.24	resistance.24	NOUN
ajlm-801	46	34	resolution	resolution	NOUN
ajlm-801	46	35	testing	testing	NOUN
ajlm-801	46	36	using	use	VERB
ajlm-801	46	37	the	the	DET
ajlm-801	46	38	modified	modified	PROPN
ajlm-801	46	39	wayne	wayne	PROPN
ajlm-801	46	40	’s	’s	PART
ajlm-801	46	41	test	test	NOUN
ajlm-801	46	42	confirmed	confirm	VERB
ajlm-801	46	43	susceptibility	susceptibility	NOUN
ajlm-801	46	44	.	.	PUNCT
ajlm-801	47	1	the	the	DET
ajlm-801	47	2	phenotypically	phenotypically	ADV
ajlm-801	47	3	discordant	discordant	ADJ
ajlm-801	47	4	fluoroquinolone	fluoroquinolone	NOUN
ajlm-801	47	5	isolates	isolate	NOUN
ajlm-801	47	6	(	(	PUNCT
ajlm-801	47	7	n	n	NOUN
ajlm-801	47	8	=	=	SYM
ajlm-801	47	9	3	3	X
ajlm-801	47	10	)	)	PUNCT
ajlm-801	47	11	were	be	AUX
ajlm-801	47	12	predicted	predict	VERB
ajlm-801	47	13	to	to	PART
ajlm-801	47	14	be	be	AUX
ajlm-801	47	15	susceptible	susceptible	ADJ
ajlm-801	47	16	by	by	ADP
ajlm-801	47	17	wgs	wgs	NOUN
ajlm-801	47	18	,	,	PUNCT
ajlm-801	47	19	displaying	display	VERB
ajlm-801	47	20	a	a	DET
ajlm-801	47	21	wild	wild	ADJ
ajlm-801	47	22	-	-	PUNCT
ajlm-801	47	23	type	type	NOUN
ajlm-801	47	24	gyra	gyra	NOUN
ajlm-801	47	25	and	and	CCONJ
ajlm-801	47	26	gyrb	gyrb	PROPN
ajlm-801	47	27	gene	gene	NOUN
ajlm-801	47	28	.	.	PUNCT
ajlm-801	48	1	repeat	repeat	PROPN
ajlm-801	48	2	dst	dst	PROPN
ajlm-801	48	3	was	be	AUX
ajlm-801	48	4	in	in	ADP
ajlm-801	48	5	agreement	agreement	NOUN
ajlm-801	48	6	with	with	ADP
ajlm-801	48	7	wgs	wgs	NOUN
ajlm-801	48	8	for	for	ADP
ajlm-801	48	9	moxifloxacin	moxifloxacin	NUM
ajlm-801	48	10	;	;	PUNCT
ajlm-801	48	11	however	however	ADV
ajlm-801	48	12	,	,	PUNCT
ajlm-801	48	13	two	two	NUM
ajlm-801	48	14	of	of	ADP
ajlm-801	48	15	the	the	DET
ajlm-801	48	16	three	three	NUM
ajlm-801	48	17	isolates	isolate	NOUN
ajlm-801	48	18	remained	remain	VERB
ajlm-801	48	19	resistant	resistant	ADJ
ajlm-801	48	20	to	to	ADP
ajlm-801	48	21	ofloxacin	ofloxacin	NOUN
ajlm-801	48	22	.	.	PUNCT
ajlm-801	49	1	resolution	resolution	NOUN
ajlm-801	49	2	testing	testing	NOUN
ajlm-801	49	3	using	use	VERB
ajlm-801	49	4	the	the	DET
ajlm-801	49	5	broth	broth	NOUN
ajlm-801	49	6	microdilution	microdilution	NOUN
ajlm-801	49	7	assay	assay	NOUN
ajlm-801	49	8	confirmed	confirm	VERB
ajlm-801	49	9	susceptibility	susceptibility	NOUN
ajlm-801	49	10	for	for	ADP
ajlm-801	49	11	both	both	DET
ajlm-801	49	12	isolates	isolate	NOUN
ajlm-801	49	13	,	,	PUNCT
ajlm-801	49	14	showing	show	VERB
ajlm-801	49	15	a	a	DET
ajlm-801	49	16	minimum	minimum	ADJ
ajlm-801	49	17	inhibitory	inhibitory	ADJ
ajlm-801	49	18	concentration	concentration	NOUN
ajlm-801	49	19	of	of	ADP
ajlm-801	49	20	1	1	NUM
ajlm-801	49	21	µg	µg	NOUN
ajlm-801	49	22	/	/	SYM
ajlm-801	49	23	ml	ml	NOUN
ajlm-801	49	24	.	.	NOUN
ajlm-801	49	25	wgs	wgs	NOUN
ajlm-801	49	26	for	for	ADP
ajlm-801	49	27	novel	novel	ADJ
ajlm-801	49	28	drugs	drug	NOUN
ajlm-801	49	29	bedaquiline	bedaquiline	NOUN
ajlm-801	49	30	and	and	CCONJ
ajlm-801	49	31	delamanid	delamanid	PROPN
ajlm-801	49	32	showed	show	VERB
ajlm-801	49	33	no	no	DET
ajlm-801	49	34	resistance	resistance	NOUN
ajlm-801	49	35	-	-	PUNCT
ajlm-801	49	36	associated	associate	VERB
ajlm-801	49	37	mutations	mutation	NOUN
ajlm-801	49	38	.	.	PUNCT
ajlm-801	50	1	discussion	discussion	NOUN
ajlm-801	50	2	the	the	DET
ajlm-801	50	3	application	application	NOUN
ajlm-801	50	4	of	of	ADP
ajlm-801	50	5	whole	whole	ADJ
ajlm-801	50	6	genome	genome	NOUN
ajlm-801	50	7	next	next	ADJ
ajlm-801	50	8	-	-	PUNCT
ajlm-801	50	9	generation	generation	NOUN
ajlm-801	50	10	sequencing	sequence	VERB
ajlm-801	50	11	technology	technology	NOUN
ajlm-801	50	12	for	for	ADP
ajlm-801	50	13	drug	drug	NOUN
ajlm-801	50	14	resistance	resistance	NOUN
ajlm-801	50	15	determination	determination	NOUN
ajlm-801	50	16	in	in	ADP
ajlm-801	50	17	m.	m.	NOUN
ajlm-801	50	18	tuberculosis	tuberculosis	NOUN
ajlm-801	50	19	has	have	AUX
ajlm-801	50	20	been	be	AUX
ajlm-801	50	21	shown	show	VERB
ajlm-801	50	22	to	to	PART
ajlm-801	50	23	be	be	AUX
ajlm-801	50	24	a	a	DET
ajlm-801	50	25	valuable	valuable	ADJ
ajlm-801	50	26	tool	tool	NOUN
ajlm-801	50	27	in	in	ADP
ajlm-801	50	28	this	this	DET
ajlm-801	50	29	study	study	NOUN
ajlm-801	50	30	.	.	PUNCT
ajlm-801	51	1	despite	despite	SCONJ
ajlm-801	51	2	the	the	DET
ajlm-801	51	3	small	small	ADJ
ajlm-801	51	4	sample	sample	NOUN
ajlm-801	51	5	size	size	NOUN
ajlm-801	51	6	,	,	PUNCT
ajlm-801	51	7	the	the	DET
ajlm-801	51	8	performance	performance	NOUN
ajlm-801	51	9	of	of	ADP
ajlm-801	51	10	wgs	wgs	NOUN
ajlm-801	51	11	for	for	ADP
ajlm-801	51	12	predicting	predict	VERB
ajlm-801	51	13	resistance	resistance	NOUN
ajlm-801	51	14	was	be	AUX
ajlm-801	51	15	consistent	consistent	ADJ
ajlm-801	51	16	with	with	ADP
ajlm-801	51	17	published	publish	VERB
ajlm-801	51	18	studies	study	NOUN
ajlm-801	51	19	containing	contain	VERB
ajlm-801	51	20	subsets	subset	NOUN
ajlm-801	51	21	of	of	ADP
ajlm-801	51	22	south	south	ADJ
ajlm-801	51	23	african	african	ADJ
ajlm-801	51	24	isolates.25,26	isolates.25,26	NOUN
ajlm-801	51	25	the	the	DET
ajlm-801	51	26	use	use	NOUN
ajlm-801	51	27	of	of	ADP
ajlm-801	51	28	the	the	DET
ajlm-801	51	29	miseq	miseq	ADJ
ajlm-801	51	30	®	®	NOUN
ajlm-801	51	31	offers	offer	VERB
ajlm-801	51	32	reduced	reduce	VERB
ajlm-801	51	33	hands	hand	NOUN
ajlm-801	51	34	-	-	PUNCT
ajlm-801	51	35	on	on	ADP
ajlm-801	51	36	preparation	preparation	NOUN
ajlm-801	51	37	time	time	NOUN
ajlm-801	51	38	(	(	PUNCT
ajlm-801	51	39	~6	~6	NOUN
ajlm-801	51	40	h	h	NOUN
ajlm-801	51	41	per	per	ADP
ajlm-801	51	42	batch	batch	NOUN
ajlm-801	51	43	of	of	ADP
ajlm-801	51	44	isolates	isolate	NOUN
ajlm-801	51	45	)	)	PUNCT
ajlm-801	51	46	compared	compare	VERB
ajlm-801	51	47	to	to	ADP
ajlm-801	51	48	other	other	ADJ
ajlm-801	51	49	next	next	ADJ
ajlm-801	51	50	-	-	PUNCT
ajlm-801	51	51	generation	generation	NOUN
ajlm-801	51	52	sequencing	sequence	VERB
ajlm-801	51	53	technologies.27	technologies.27	ADJ
ajlm-801	51	54	bioinformatic	bioinformatic	ADJ
ajlm-801	51	55	analysis	analysis	NOUN
ajlm-801	51	56	using	use	VERB
ajlm-801	51	57	the	the	DET
ajlm-801	51	58	commercial	commercial	ADJ
ajlm-801	51	59	software	software	NOUN
ajlm-801	51	60	was	be	AUX
ajlm-801	51	61	relatively	relatively	ADV
ajlm-801	51	62	straightforward	straightforward	ADJ
ajlm-801	51	63	,	,	PUNCT
ajlm-801	51	64	particularly	particularly	ADV
ajlm-801	51	65	the	the	DET
ajlm-801	51	66	use	use	NOUN
ajlm-801	51	67	of	of	ADP
ajlm-801	51	68	workflows	workflow	NOUN
ajlm-801	51	69	for	for	ADP
ajlm-801	51	70	automation	automation	NOUN
ajlm-801	51	71	.	.	PUNCT
ajlm-801	52	1	once	once	ADV
ajlm-801	52	2	a	a	DET
ajlm-801	52	3	workflow	workflow	NOUN
ajlm-801	52	4	is	be	AUX
ajlm-801	52	5	saved	save	VERB
ajlm-801	52	6	,	,	PUNCT
ajlm-801	52	7	imported	import	VERB
ajlm-801	52	8	data	datum	NOUN
ajlm-801	52	9	are	be	AUX
ajlm-801	52	10	automatically	automatically	ADV
ajlm-801	52	11	analysed	analyse	VERB
ajlm-801	52	12	,	,	PUNCT
ajlm-801	52	13	producing	produce	VERB
ajlm-801	52	14	a	a	DET
ajlm-801	52	15	final	final	ADJ
ajlm-801	52	16	output	output	NOUN
ajlm-801	52	17	table	table	NOUN
ajlm-801	52	18	displaying	display	VERB
ajlm-801	52	19	mutations	mutation	NOUN
ajlm-801	52	20	.	.	PUNCT
ajlm-801	53	1	however	however	ADV
ajlm-801	53	2	,	,	PUNCT
ajlm-801	53	3	sequence	sequence	NOUN
ajlm-801	53	4	analysis	analysis	NOUN
ajlm-801	53	5	requires	require	VERB
ajlm-801	53	6	an	an	DET
ajlm-801	53	7	understanding	understanding	NOUN
ajlm-801	53	8	of	of	ADP
ajlm-801	53	9	the	the	DET
ajlm-801	53	10	associated	associated	ADJ
ajlm-801	53	11	genetic	genetic	ADJ
ajlm-801	53	12	targets	target	NOUN
ajlm-801	53	13	and	and	CCONJ
ajlm-801	53	14	drug	drug	NOUN
ajlm-801	53	15	resistance	resistance	NOUN
ajlm-801	53	16	mutations	mutation	NOUN
ajlm-801	53	17	.	.	PUNCT
ajlm-801	54	1	concordance	concordance	NOUN
ajlm-801	54	2	of	of	ADP
ajlm-801	54	3	wgs	wgs	NOUN
ajlm-801	54	4	with	with	ADP
ajlm-801	54	5	initial	initial	ADJ
ajlm-801	54	6	mgit	mgit	ADJ
ajlm-801	54	7	dst	dst	PROPN
ajlm-801	54	8	was	be	AUX
ajlm-801	54	9	lacking	lack	VERB
ajlm-801	54	10	for	for	ADP
ajlm-801	54	11	isoniazid	isoniazid	NOUN
ajlm-801	54	12	,	,	PUNCT
ajlm-801	54	13	pyrazinamide	pyrazinamide	NOUN
ajlm-801	54	14	and	and	CCONJ
ajlm-801	54	15	fluoroquinolones	fluoroquinolone	NOUN
ajlm-801	54	16	;	;	PUNCT
ajlm-801	54	17	however	however	ADV
ajlm-801	54	18	,	,	PUNCT
ajlm-801	54	19	resolution	resolution	NOUN
ajlm-801	54	20	testing	testing	NOUN
ajlm-801	54	21	improved	improve	VERB
ajlm-801	54	22	agreement	agreement	NOUN
ajlm-801	54	23	between	between	ADP
ajlm-801	54	24	wgs	wgs	NOUN
ajlm-801	54	25	and	and	CCONJ
ajlm-801	54	26	phenotypic	phenotypic	ADJ
ajlm-801	54	27	drug	drug	NOUN
ajlm-801	54	28	susceptibility	susceptibility	NOUN
ajlm-801	54	29	profiles	profile	NOUN
ajlm-801	54	30	for	for	ADP
ajlm-801	54	31	the	the	DET
ajlm-801	54	32	discordant	discordant	ADJ
ajlm-801	54	33	isolates	isolate	NOUN
ajlm-801	54	34	,	,	PUNCT
ajlm-801	54	35	even	even	ADV
ajlm-801	54	36	at	at	ADP
ajlm-801	54	37	a	a	DET
ajlm-801	54	38	coverage	coverage	NOUN
ajlm-801	54	39	of	of	ADP
ajlm-801	54	40	5×	5×	PROPN
ajlm-801	54	41	(	(	PUNCT
ajlm-801	54	42	paired	pair	VERB
ajlm-801	54	43	)	)	PUNCT
ajlm-801	54	44	with	with	ADP
ajlm-801	54	45	acceptable	acceptable	ADJ
ajlm-801	54	46	quality	quality	NOUN
ajlm-801	54	47	scores	score	NOUN
ajlm-801	54	48	.	.	PUNCT
ajlm-801	55	1	the	the	DET
ajlm-801	55	2	use	use	NOUN
ajlm-801	55	3	of	of	ADP
ajlm-801	55	4	this	this	DET
ajlm-801	55	5	technology	technology	NOUN
ajlm-801	55	6	for	for	ADP
ajlm-801	55	7	resistance	resistance	NOUN
ajlm-801	55	8	determination	determination	NOUN
ajlm-801	55	9	in	in	ADP
ajlm-801	55	10	m.	m.	NOUN
ajlm-801	55	11	tuberculosis	tuberculosis	NOUN
ajlm-801	55	12	is	be	AUX
ajlm-801	55	13	currently	currently	ADV
ajlm-801	55	14	limited	limit	VERB
ajlm-801	55	15	due	due	ADP
ajlm-801	55	16	to	to	ADP
ajlm-801	55	17	the	the	DET
ajlm-801	55	18	lack	lack	NOUN
ajlm-801	55	19	of	of	ADP
ajlm-801	55	20	a	a	DET
ajlm-801	55	21	comprehensive	comprehensive	ADJ
ajlm-801	55	22	tuberculosis	tuberculosis	NOUN
ajlm-801	55	23	mutation	mutation	NOUN
ajlm-801	55	24	catalogue	catalogue	NOUN
ajlm-801	55	25	predicting	predict	VERB
ajlm-801	55	26	susceptibility	susceptibility	NOUN
ajlm-801	55	27	,	,	PUNCT
ajlm-801	55	28	as	as	SCONJ
ajlm-801	55	29	seen	see	VERB
ajlm-801	55	30	in	in	ADP
ajlm-801	55	31	the	the	DET
ajlm-801	55	32	case	case	NOUN
ajlm-801	55	33	of	of	ADP
ajlm-801	55	34	the	the	DET
ajlm-801	55	35	pncathr114met	pncathr114met	NOUN
ajlm-801	55	36	mutation	mutation	NOUN
ajlm-801	55	37	in	in	ADP
ajlm-801	55	38	this	this	DET
ajlm-801	55	39	study	study	NOUN
ajlm-801	55	40	,	,	PUNCT
ajlm-801	55	41	which	which	PRON
ajlm-801	55	42	was	be	AUX
ajlm-801	55	43	not	not	PART
ajlm-801	55	44	associated	associate	VERB
ajlm-801	55	45	with	with	ADP
ajlm-801	55	46	resistance	resistance	NOUN
ajlm-801	55	47	.	.	PUNCT
ajlm-801	56	1	furthermore	furthermore	ADV
ajlm-801	56	2	,	,	PUNCT
ajlm-801	56	3	sequence	sequence	NOUN
ajlm-801	56	4	data	datum	NOUN
ajlm-801	56	5	can	can	AUX
ajlm-801	56	6	only	only	ADV
ajlm-801	56	7	be	be	AUX
ajlm-801	56	8	generated	generate	VERB
ajlm-801	56	9	from	from	ADP
ajlm-801	56	10	cultured	cultured	ADJ
ajlm-801	56	11	isolates	isolate	NOUN
ajlm-801	56	12	,	,	PUNCT
ajlm-801	56	13	creating	create	VERB
ajlm-801	56	14	a	a	DET
ajlm-801	56	15	lag	lag	NOUN
ajlm-801	56	16	between	between	ADP
ajlm-801	56	17	specimen	speciman	NOUN
ajlm-801	56	18	receipt	receipt	NOUN
ajlm-801	56	19	and	and	CCONJ
ajlm-801	56	20	a	a	DET
ajlm-801	56	21	positive	positive	ADJ
ajlm-801	56	22	culture	culture	NOUN
ajlm-801	56	23	.	.	PUNCT
ajlm-801	57	1	despite	despite	SCONJ
ajlm-801	57	2	these	these	DET
ajlm-801	57	3	limitations	limitation	NOUN
ajlm-801	57	4	,	,	PUNCT
ajlm-801	57	5	wgs	wgs	NOUN
ajlm-801	57	6	could	could	AUX
ajlm-801	57	7	benefit	benefit	VERB
ajlm-801	57	8	the	the	DET
ajlm-801	57	9	majority	majority	NOUN
ajlm-801	57	10	of	of	ADP
ajlm-801	57	11	patients	patient	NOUN
ajlm-801	57	12	by	by	ADP
ajlm-801	57	13	enabling	enable	VERB
ajlm-801	57	14	them	they	PRON
ajlm-801	57	15	to	to	PART
ajlm-801	57	16	be	be	AUX
ajlm-801	57	17	placed	place	VERB
ajlm-801	57	18	on	on	ADP
ajlm-801	57	19	optimum	optimum	ADJ
ajlm-801	57	20	regimens	regimen	NOUN
ajlm-801	57	21	sooner	soon	ADV
ajlm-801	57	22	in	in	ADP
ajlm-801	57	23	comparison	comparison	NOUN
ajlm-801	57	24	to	to	ADP
ajlm-801	57	25	phenotypic	phenotypic	ADJ
ajlm-801	57	26	methods	method	NOUN
ajlm-801	57	27	.	.	PUNCT
ajlm-801	58	1	limitations	limitation	NOUN
ajlm-801	58	2	the	the	DET
ajlm-801	58	3	small	small	ADJ
ajlm-801	58	4	sample	sample	NOUN
ajlm-801	58	5	size	size	NOUN
ajlm-801	58	6	was	be	AUX
ajlm-801	58	7	inadequate	inadequate	ADJ
ajlm-801	58	8	for	for	ADP
ajlm-801	58	9	assessing	assess	VERB
ajlm-801	58	10	diagnostic	diagnostic	ADJ
ajlm-801	58	11	performance	performance	NOUN
ajlm-801	58	12	statistically	statistically	ADV
ajlm-801	58	13	.	.	PUNCT
ajlm-801	59	1	in	in	ADP
ajlm-801	59	2	addition	addition	NOUN
ajlm-801	59	3	,	,	PUNCT
ajlm-801	59	4	the	the	DET
ajlm-801	59	5	data	datum	NOUN
ajlm-801	59	6	are	be	AUX
ajlm-801	59	7	based	base	VERB
ajlm-801	59	8	on	on	ADP
ajlm-801	59	9	a	a	DET
ajlm-801	59	10	first	first	ADJ
ajlm-801	59	11	attempt	attempt	NOUN
ajlm-801	59	12	without	without	ADP
ajlm-801	59	13	any	any	DET
ajlm-801	59	14	optimisation	optimisation	NOUN
ajlm-801	59	15	for	for	ADP
ajlm-801	59	16	sequence	sequence	NOUN
ajlm-801	59	17	output	output	NOUN
ajlm-801	59	18	.	.	PUNCT
ajlm-801	60	1	conclusion	conclusion	NOUN
ajlm-801	60	2	wgs	wgs	NOUN
ajlm-801	60	3	correctly	correctly	ADV
ajlm-801	60	4	predicted	predict	VERB
ajlm-801	60	5	resistance	resistance	NOUN
ajlm-801	60	6	or	or	CCONJ
ajlm-801	60	7	susceptibility	susceptibility	NOUN
ajlm-801	60	8	using	use	VERB
ajlm-801	60	9	commercial	commercial	ADJ
ajlm-801	60	10	bioinformatics	bioinformatics	NOUN
ajlm-801	60	11	software	software	NOUN
ajlm-801	60	12	based	base	VERB
ajlm-801	60	13	on	on	ADP
ajlm-801	60	14	already	already	ADV
ajlm-801	60	15	identified	identify	VERB
ajlm-801	60	16	resistance	resistance	NOUN
ajlm-801	60	17	-	-	PUNCT
ajlm-801	60	18	determining	determine	VERB
ajlm-801	60	19	mutations	mutation	NOUN
ajlm-801	60	20	.	.	PUNCT
ajlm-801	61	1	our	our	PRON
ajlm-801	61	2	findings	finding	NOUN
ajlm-801	61	3	suggest	suggest	VERB
ajlm-801	61	4	the	the	DET
ajlm-801	61	5	system	system	NOUN
ajlm-801	61	6	shows	show	VERB
ajlm-801	61	7	promise	promise	NOUN
ajlm-801	61	8	as	as	ADP
ajlm-801	61	9	a	a	DET
ajlm-801	61	10	tool	tool	NOUN
ajlm-801	61	11	for	for	ADP
ajlm-801	61	12	predicting	predict	VERB
ajlm-801	61	13	drug	drug	NOUN
ajlm-801	61	14	resistance	resistance	NOUN
ajlm-801	61	15	in	in	ADP
ajlm-801	61	16	a	a	DET
ajlm-801	61	17	short	short	ADJ
ajlm-801	61	18	time	time	NOUN
ajlm-801	61	19	frame	frame	NOUN
ajlm-801	61	20	for	for	ADP
ajlm-801	61	21	multiple	multiple	ADJ
ajlm-801	61	22	drugs	drug	NOUN
ajlm-801	61	23	and	and	CCONJ
ajlm-801	61	24	multiple	multiple	ADJ
ajlm-801	61	25	samples	sample	NOUN
ajlm-801	61	26	simultaneously	simultaneously	ADV
ajlm-801	61	27	,	,	PUNCT
ajlm-801	61	28	provided	provide	VERB
ajlm-801	61	29	the	the	DET
ajlm-801	61	30	genetic	genetic	ADJ
ajlm-801	61	31	basis	basis	NOUN
ajlm-801	61	32	for	for	ADP
ajlm-801	61	33	resistance	resistance	NOUN
ajlm-801	61	34	is	be	AUX
ajlm-801	61	35	well	well	ADV
ajlm-801	61	36	described	describe	VERB
ajlm-801	61	37	.	.	PUNCT
ajlm-801	62	1	acknowledgements	acknowledgement	NOUN
ajlm-801	62	2	detailed	detail	VERB
ajlm-801	62	3	wgs	wgs	NOUN
ajlm-801	62	4	results	result	NOUN
ajlm-801	62	5	and	and	CCONJ
ajlm-801	62	6	statistics	statistic	NOUN
ajlm-801	62	7	are	be	AUX
ajlm-801	62	8	available	available	ADJ
ajlm-801	62	9	from	from	ADP
ajlm-801	62	10	the	the	DET
ajlm-801	62	11	corresponding	corresponding	ADJ
ajlm-801	62	12	author	author	NOUN
ajlm-801	62	13	.	.	PUNCT
ajlm-801	63	1	we	we	PRON
ajlm-801	63	2	would	would	AUX
ajlm-801	63	3	like	like	VERB
ajlm-801	63	4	to	to	PART
ajlm-801	63	5	thank	thank	VERB
ajlm-801	63	6	professor	professor	PROPN
ajlm-801	63	7	jasper	jasper	NOUN
ajlm-801	63	8	rees	rees	PROPN
ajlm-801	63	9	and	and	CCONJ
ajlm-801	63	10	jonathan	jonathan	PROPN
ajlm-801	63	11	feathers	feather	NOUN
ajlm-801	63	12	(	(	PUNCT
ajlm-801	63	13	agricultural	agricultural	ADJ
ajlm-801	63	14	research	research	NOUN
ajlm-801	63	15	council	council	PROPN
ajlm-801	63	16	,	,	PUNCT
ajlm-801	63	17	biotechnology	biotechnology	NOUN
ajlm-801	63	18	platform	platform	NOUN
ajlm-801	63	19	,	,	PUNCT
ajlm-801	63	20	pretoria	pretoria	NOUN
ajlm-801	63	21	,	,	PUNCT
ajlm-801	63	22	south	south	PROPN
ajlm-801	63	23	africa	africa	PROPN
ajlm-801	63	24	)	)	PUNCT
ajlm-801	63	25	for	for	ADP
ajlm-801	63	26	their	their	PRON
ajlm-801	63	27	valuable	valuable	ADJ
ajlm-801	63	28	input	input	NOUN
ajlm-801	63	29	and	and	CCONJ
ajlm-801	63	30	assistance	assistance	NOUN
ajlm-801	63	31	.	.	PUNCT
ajlm-801	64	1	we	we	PRON
ajlm-801	64	2	further	far	ADV
ajlm-801	64	3	would	would	AUX
ajlm-801	64	4	like	like	VERB
ajlm-801	64	5	to	to	PART
ajlm-801	64	6	thank	thank	VERB
ajlm-801	64	7	the	the	DET
ajlm-801	64	8	technical	technical	ADJ
ajlm-801	64	9	staff	staff	NOUN
ajlm-801	64	10	at	at	ADP
ajlm-801	64	11	the	the	DET
ajlm-801	64	12	centre	centre	NOUN
ajlm-801	64	13	for	for	ADP
ajlm-801	64	14	tuberculosis	tuberculosis	NOUN
ajlm-801	64	15	.	.	PUNCT
ajlm-801	65	1	competing	compete	VERB
ajlm-801	65	2	interests	interest	NOUN
ajlm-801	65	3	the	the	DET
ajlm-801	65	4	authors	author	NOUN
ajlm-801	65	5	declare	declare	VERB
ajlm-801	65	6	that	that	SCONJ
ajlm-801	65	7	they	they	PRON
ajlm-801	65	8	have	have	VERB
ajlm-801	65	9	no	no	DET
ajlm-801	65	10	financial	financial	ADJ
ajlm-801	65	11	or	or	CCONJ
ajlm-801	65	12	personal	personal	ADJ
ajlm-801	65	13	relationships	relationship	NOUN
ajlm-801	65	14	which	which	PRON
ajlm-801	65	15	may	may	AUX
ajlm-801	65	16	have	have	AUX
ajlm-801	65	17	inappropriately	inappropriately	ADV
ajlm-801	65	18	influenced	influence	VERB
ajlm-801	65	19	them	they	PRON
ajlm-801	65	20	in	in	ADP
ajlm-801	65	21	writing	write	VERB
ajlm-801	65	22	this	this	DET
ajlm-801	65	23	article	article	NOUN
ajlm-801	65	24	.	.	PUNCT
ajlm-801	66	1	sources	source	NOUN
ajlm-801	66	2	of	of	ADP
ajlm-801	66	3	support	support	NOUN
ajlm-801	66	4	funding	funding	NOUN
ajlm-801	66	5	was	be	AUX
ajlm-801	66	6	provided	provide	VERB
ajlm-801	66	7	by	by	ADP
ajlm-801	66	8	the	the	DET
ajlm-801	66	9	national	national	PROPN
ajlm-801	66	10	institute	institute	PROPN
ajlm-801	66	11	for	for	ADP
ajlm-801	66	12	communicable	communicable	NOUN
ajlm-801	66	13	diseases	disease	NOUN
ajlm-801	66	14	,	,	PUNCT
ajlm-801	66	15	a	a	DET
ajlm-801	66	16	division	division	NOUN
ajlm-801	66	17	of	of	ADP
ajlm-801	66	18	the	the	DET
ajlm-801	66	19	national	national	PROPN
ajlm-801	66	20	health	health	PROPN
ajlm-801	66	21	laboratory	laboratory	PROPN
ajlm-801	66	22	service	service	PROPN
ajlm-801	66	23	,	,	PUNCT
ajlm-801	66	24	south	south	PROPN
ajlm-801	66	25	africa	africa	PROPN
ajlm-801	66	26	.	.	PUNCT
ajlm-801	67	1	authors	author	NOUN
ajlm-801	67	2	’	’	PART
ajlm-801	67	3	contributions	contribution	NOUN
ajlm-801	67	4	n.a.i	n.a.i	PROPN
ajlm-801	67	5	.	.	PUNCT
ajlm-801	67	6	and	and	CCONJ
ajlm-801	67	7	s.v.o	s.v.o	PROPN
ajlm-801	67	8	.	.	PUNCT
ajlm-801	67	9	were	be	AUX
ajlm-801	67	10	the	the	DET
ajlm-801	67	11	project	project	NOUN
ajlm-801	67	12	leads	lead	VERB
ajlm-801	67	13	.	.	PUNCT
ajlm-801	68	1	s.v.o	s.v.o	PROPN
ajlm-801	68	2	.	.	PROPN
ajlm-801	68	3	,	,	PUNCT
ajlm-801	68	4	n.a.i	n.a.i	PROPN
ajlm-801	68	5	.	.	PROPN
ajlm-801	68	6	,	,	PUNCT
ajlm-801	68	7	l.j	l.j	PROPN
ajlm-801	68	8	.	.	PROPN
ajlm-801	68	9	,	,	PUNCT
ajlm-801	68	10	h.m.s	h.m.	NOUN
ajlm-801	68	11	.	.	PUNCT
ajlm-801	69	1	and	and	CCONJ
ajlm-801	69	2	f.i	f.i	PROPN
ajlm-801	69	3	.	.	PROPN
ajlm-801	69	4	were	be	AUX
ajlm-801	69	5	responsible	responsible	ADJ
ajlm-801	69	6	for	for	ADP
ajlm-801	69	7	the	the	DET
ajlm-801	69	8	experimental	experimental	ADJ
ajlm-801	69	9	and	and	CCONJ
ajlm-801	69	10	project	project	NOUN
ajlm-801	69	11	designs	design	NOUN
ajlm-801	69	12	.	.	PUNCT
ajlm-801	70	1	s.v.o	s.v.o	PROPN
ajlm-801	70	2	.	.	PROPN
ajlm-801	70	3	,	,	PUNCT
ajlm-801	70	4	l.j	l.j	AUX
ajlm-801	70	5	.	.	PROPN
ajlm-801	70	6	,	,	PUNCT
ajlm-801	70	7	h.m.s	h.m.	NOUN
ajlm-801	70	8	.	.	PROPN
ajlm-801	70	9	,	,	PUNCT
ajlm-801	70	10	n.i	n.i	PROPN
ajlm-801	70	11	.	.	PROPN
ajlm-801	70	12	and	and	CCONJ
ajlm-801	70	13	t.l.g	t.l.g	PROPN
ajlm-801	70	14	.	.	PROPN
ajlm-801	70	15	performed	perform	VERB
ajlm-801	70	16	most	most	ADJ
ajlm-801	70	17	of	of	ADP
ajlm-801	70	18	the	the	DET
ajlm-801	70	19	experiments	experiment	NOUN
ajlm-801	70	20	.	.	PUNCT
ajlm-801	71	1	calculations	calculation	NOUN
ajlm-801	71	2	were	be	AUX
ajlm-801	71	3	performed	perform	VERB
ajlm-801	71	4	by	by	ADP
ajlm-801	71	5	s.v.o	s.v.o	PROPN
ajlm-801	71	6	.	.	PUNCT
ajlm-801	72	1	and	and	CCONJ
ajlm-801	72	2	n.a.i	n.a.i	PROPN
ajlm-801	72	3	.	.	PUNCT
ajlm-801	73	1	references	reference	NOUN
ajlm-801	73	2	who	who	PRON
ajlm-801	73	3	.	.	PUNCT
ajlm-801	74	1	who	who	PRON
ajlm-801	74	2	,	,	PUNCT
ajlm-801	74	3	editor	editor	NOUN
ajlm-801	74	4	.	.	PUNCT
ajlm-801	75	1	global	global	ADJ
ajlm-801	75	2	tuberculosis	tuberculosis	NOUN
ajlm-801	75	3	report	report	NOUN
ajlm-801	75	4	2017	2017	NUM
ajlm-801	75	5	[	[	X
ajlm-801	75	6	homepage	homepage	NOUN
ajlm-801	75	7	on	on	ADP
ajlm-801	75	8	the	the	DET
ajlm-801	75	9	internet	internet	NOUN
ajlm-801	75	10	]	]	PUNCT
ajlm-801	75	11	.	.	PUNCT
ajlm-801	76	1	geneva	geneva	PROPN
ajlm-801	76	2	,	,	PUNCT
ajlm-801	76	3	switzerland	switzerland	PROPN
ajlm-801	76	4	:	:	PUNCT
ajlm-801	76	5	who	who	PRON
ajlm-801	76	6	press	press	VERB
ajlm-801	76	7	;	;	PUNCT
ajlm-801	76	8	2017	2017	NUM
ajlm-801	77	1	[	[	PUNCT
ajlm-801	77	2	cited	cite	VERB
ajlm-801	77	3	2018	2018	NUM
ajlm-801	77	4	jan	jan	PROPN
ajlm-801	77	5	12	12	NUM
ajlm-801	77	6	]	]	PUNCT
ajlm-801	77	7	.	.	PUNCT
ajlm-801	78	1	available	available	ADJ
ajlm-801	78	2	from	from	ADP
ajlm-801	78	3	:	:	PUNCT
ajlm-801	78	4	http://apps.who.int/iris/bitstream/10665/259366/1/9789241565516-eng.pdf?ua=1	http://apps.who.int/iris/bitstream/10665/259366/1/9789241565516-eng.pdf?ua=1	NOUN
ajlm-801	78	5	gandhi	gandhi	PROPN
ajlm-801	78	6	nr	nr	PROPN
ajlm-801	78	7	,	,	PUNCT
ajlm-801	78	8	nunn	nunn	PROPN
ajlm-801	78	9	p	p	PROPN
ajlm-801	78	10	,	,	PUNCT
ajlm-801	78	11	dheda	dheda	PROPN
ajlm-801	78	12	k	k	PROPN
ajlm-801	78	13	,	,	PUNCT
ajlm-801	78	14	et	et	PROPN
ajlm-801	78	15	al	al	PROPN
ajlm-801	78	16	.	.	PROPN
ajlm-801	78	17	multidrug	multidrug	NOUN
ajlm-801	78	18	-	-	PUNCT
ajlm-801	78	19	resistant	resistant	ADJ
ajlm-801	78	20	and	and	CCONJ
ajlm-801	78	21	extensively	extensively	ADV
ajlm-801	78	22	drug	drug	NOUN
ajlm-801	78	23	-	-	PUNCT
ajlm-801	78	24	resistant	resistant	ADJ
ajlm-801	78	25	tuberculosis	tuberculosis	NOUN
ajlm-801	78	26	:	:	PUNCT
ajlm-801	78	27	a	a	DET
ajlm-801	78	28	threat	threat	NOUN
ajlm-801	78	29	to	to	ADP
ajlm-801	78	30	global	global	ADJ
ajlm-801	78	31	control	control	NOUN
ajlm-801	78	32	of	of	ADP
ajlm-801	78	33	tuberculosis	tuberculosis	NOUN
ajlm-801	78	34	.	.	PUNCT
ajlm-801	79	1	lancet	lancet	PROPN
ajlm-801	79	2	.	.	PUNCT
ajlm-801	80	1	2010;375(9728):1830–1843	2010;375(9728):1830–1843	X
ajlm-801	80	2	.	.	PUNCT
ajlm-801	80	3	https://doi.org/10.1016/s0140-6736(10)60410-2	https://doi.org/10.1016/s0140-6736(10)60410-2	PROPN
ajlm-801	80	4	klopper	klopper	PROPN
ajlm-801	80	5	m	m	PROPN
ajlm-801	80	6	,	,	PUNCT
ajlm-801	80	7	warren	warren	PROPN
ajlm-801	80	8	rm	rm	PROPN
ajlm-801	80	9	,	,	PUNCT
ajlm-801	80	10	hayes	hayes	PROPN
ajlm-801	80	11	c	c	PROPN
ajlm-801	80	12	,	,	PUNCT
ajlm-801	80	13	et	et	PROPN
ajlm-801	80	14	al	al	PROPN
ajlm-801	80	15	.	.	PROPN
ajlm-801	80	16	emergence	emergence	NOUN
ajlm-801	80	17	and	and	CCONJ
ajlm-801	80	18	spread	spread	VERB
ajlm-801	80	19	of	of	ADP
ajlm-801	80	20	extensively	extensively	ADV
ajlm-801	80	21	and	and	CCONJ
ajlm-801	80	22	totally	totally	ADV
ajlm-801	80	23	drug	drug	NOUN
ajlm-801	80	24	-	-	PUNCT
ajlm-801	80	25	resistant	resistant	ADJ
ajlm-801	80	26	tuberculosis	tuberculosis	NOUN
ajlm-801	80	27	,	,	PUNCT
ajlm-801	80	28	south	south	PROPN
ajlm-801	80	29	africa	africa	PROPN
ajlm-801	80	30	.	.	PUNCT
ajlm-801	81	1	emerg	emerg	PROPN
ajlm-801	81	2	infect	infect	PROPN
ajlm-801	81	3	dis	dis	PROPN
ajlm-801	81	4	.	.	PUNCT
ajlm-801	82	1	2013;19(3):449–455	2013;19(3):449–455	X
ajlm-801	82	2	.	.	PUNCT
ajlm-801	82	3	https://doi.org/10.3201/eid1903.120246	https://doi.org/10.3201/eid1903.120246	PROPN
ajlm-801	82	4	muller	muller	PROPN
ajlm-801	82	5	b	b	PROPN
ajlm-801	82	6	,	,	PUNCT
ajlm-801	82	7	chihota	chihota	PROPN
ajlm-801	82	8	vn	vn	PROPN
ajlm-801	82	9	,	,	PUNCT
ajlm-801	82	10	pillay	pillay	PROPN
ajlm-801	82	11	m	m	PROPN
ajlm-801	82	12	,	,	PUNCT
ajlm-801	82	13	et	et	PROPN
ajlm-801	82	14	al	al	PROPN
ajlm-801	82	15	.	.	PROPN
ajlm-801	82	16	programmatically	programmatically	ADV
ajlm-801	82	17	selected	select	VERB
ajlm-801	82	18	multidrug	multidrug	NOUN
ajlm-801	82	19	-	-	PUNCT
ajlm-801	82	20	resistant	resistant	ADJ
ajlm-801	82	21	strains	strain	NOUN
ajlm-801	82	22	drive	drive	VERB
ajlm-801	82	23	the	the	DET
ajlm-801	82	24	emergence	emergence	NOUN
ajlm-801	82	25	of	of	ADP
ajlm-801	82	26	extensively	extensively	ADV
ajlm-801	82	27	drug	drug	NOUN
ajlm-801	82	28	-	-	PUNCT
ajlm-801	82	29	resistant	resistant	ADJ
ajlm-801	82	30	tuberculosis	tuberculosis	NOUN
ajlm-801	82	31	in	in	ADP
ajlm-801	82	32	south	south	PROPN
ajlm-801	82	33	africa	africa	PROPN
ajlm-801	82	34	.	.	PUNCT
ajlm-801	83	1	plos	plos	PROPN
ajlm-801	83	2	one	one	NUM
ajlm-801	83	3	.	.	PUNCT
ajlm-801	84	1	2013;8(8):e70919	2013;8(8):e70919	PROPN
ajlm-801	84	2	.	.	PUNCT
ajlm-801	85	1	https://doi.org/10.1371/journal.pone.0070919	https://doi.org/10.1371/journal.pone.0070919	PROPN
ajlm-801	85	2	gurbanova	gurbanova	PROPN
ajlm-801	85	3	e	e	NOUN
ajlm-801	85	4	,	,	PUNCT
ajlm-801	85	5	mehdiyev	mehdiyev	NOUN
ajlm-801	85	6	r	r	NOUN
ajlm-801	85	7	,	,	PUNCT
ajlm-801	85	8	blondal	blondal	NOUN
ajlm-801	85	9	k	k	PROPN
ajlm-801	85	10	,	,	PUNCT
ajlm-801	85	11	et	et	PROPN
ajlm-801	85	12	al	al	PROPN
ajlm-801	85	13	.	.	PUNCT
ajlm-801	85	14	mitigation	mitigation	NOUN
ajlm-801	85	15	of	of	ADP
ajlm-801	85	16	discordant	discordant	ADJ
ajlm-801	85	17	rifampicin	rifampicin	VERB
ajlm-801	85	18	-	-	PUNCT
ajlm-801	85	19	susceptibility	susceptibility	NOUN
ajlm-801	85	20	results	result	NOUN
ajlm-801	85	21	obtained	obtain	VERB
ajlm-801	85	22	by	by	ADP
ajlm-801	85	23	xpert	xpert	PROPN
ajlm-801	85	24	mycobacterium	mycobacterium	PROPN
ajlm-801	85	25	tuberculosis	tuberculosis	NOUN
ajlm-801	85	26	/	/	SYM
ajlm-801	85	27	rifampicin	rifampicin	VERB
ajlm-801	85	28	and	and	CCONJ
ajlm-801	85	29	mycobacterium	mycobacterium	NOUN
ajlm-801	85	30	growth	growth	NOUN
ajlm-801	85	31	indicator	indicator	NOUN
ajlm-801	85	32	tube	tube	PROPN
ajlm-801	85	33	.	.	PUNCT
ajlm-801	86	1	microb	microb	NOUN
ajlm-801	86	2	drug	drug	NOUN
ajlm-801	86	3	resist	resist	NOUN
ajlm-801	86	4	.	.	PUNCT
ajlm-801	87	1	2017;23(8):1045–1052	2017;23(8):1045–1052	PROPN
ajlm-801	87	2	.	.	PUNCT
ajlm-801	88	1	van	van	PROPN
ajlm-801	88	2	deun	deun	PROPN
ajlm-801	88	3	a	a	X
ajlm-801	88	4	,	,	PUNCT
ajlm-801	88	5	aung	aung	PROPN
ajlm-801	88	6	kj	kj	PROPN
ajlm-801	88	7	,	,	PUNCT
ajlm-801	88	8	hossain	hossain	PROPN
ajlm-801	88	9	a	a	PROPN
ajlm-801	88	10	,	,	PUNCT
ajlm-801	88	11	et	et	PROPN
ajlm-801	88	12	al	al	PROPN
ajlm-801	88	13	.	.	PROPN
ajlm-801	88	14	disputed	dispute	VERB
ajlm-801	88	15	rpob	rpob	ADJ
ajlm-801	88	16	mutations	mutation	NOUN
ajlm-801	88	17	can	can	AUX
ajlm-801	88	18	frequently	frequently	ADV
ajlm-801	88	19	cause	cause	VERB
ajlm-801	88	20	important	important	ADJ
ajlm-801	88	21	rifampicin	rifampicin	VERB
ajlm-801	88	22	resistance	resistance	NOUN
ajlm-801	88	23	among	among	ADP
ajlm-801	88	24	new	new	ADJ
ajlm-801	88	25	tuberculosis	tuberculosis	NOUN
ajlm-801	88	26	patients	patient	NOUN
ajlm-801	88	27	.	.	PUNCT
ajlm-801	89	1	int	int	NOUN
ajlm-801	89	2	j	j	PROPN
ajlm-801	89	3	tuberc	tuberc	PROPN
ajlm-801	89	4	lung	lung	PROPN
ajlm-801	89	5	dis	dis	PROPN
ajlm-801	89	6	.	.	PUNCT
ajlm-801	90	1	2015;19(2):185–190	2015;19(2):185–190	NUM
ajlm-801	90	2	.	.	PUNCT
ajlm-801	90	3	https://doi.org/10.5588/ijtld.14.0651	https://doi.org/10.5588/ijtld.14.0651	PROPN
ajlm-801	90	4	daum	daum	PROPN
ajlm-801	90	5	lt	lt	PROPN
ajlm-801	90	6	,	,	PUNCT
ajlm-801	90	7	rodriguez	rodriguez	PROPN
ajlm-801	90	8	jd	jd	PROPN
ajlm-801	90	9	,	,	PUNCT
ajlm-801	90	10	worthy	worthy	ADJ
ajlm-801	90	11	sa	sa	PROPN
ajlm-801	90	12	,	,	PUNCT
ajlm-801	90	13	et	et	PROPN
ajlm-801	90	14	al	al	PROPN
ajlm-801	90	15	.	.	PROPN
ajlm-801	91	1	next	next	ADJ
ajlm-801	91	2	-	-	PUNCT
ajlm-801	91	3	generation	generation	NOUN
ajlm-801	91	4	ion	ion	NOUN
ajlm-801	91	5	torrent	torrent	NOUN
ajlm-801	91	6	sequencing	sequencing	NOUN
ajlm-801	91	7	of	of	ADP
ajlm-801	91	8	drug	drug	NOUN
ajlm-801	91	9	resistance	resistance	NOUN
ajlm-801	91	10	mutations	mutation	NOUN
ajlm-801	91	11	in	in	ADP
ajlm-801	91	12	mycobacterium	mycobacterium	NOUN
ajlm-801	91	13	tuberculosis	tuberculosis	NOUN
ajlm-801	91	14	strains	strain	NOUN
ajlm-801	91	15	.	.	PUNCT
ajlm-801	92	1	j	j	PROPN
ajlm-801	92	2	clin	clin	PROPN
ajlm-801	92	3	microbiol	microbiol	PROPN
ajlm-801	92	4	.	.	PUNCT
ajlm-801	93	1	2012;50(12):3831–3837	2012;50(12):3831–3837	NUM
ajlm-801	93	2	.	.	PUNCT
ajlm-801	94	1	https://doi.org/10.1128/jcm.01893-12	https://doi.org/10.1128/jcm.01893-12	PROPN
ajlm-801	94	2	köser	köser	PROPN
ajlm-801	94	3	cu	cu	PROPN
ajlm-801	94	4	,	,	PUNCT
ajlm-801	94	5	bryant	bryant	PROPN
ajlm-801	94	6	jm	jm	PROPN
ajlm-801	94	7	,	,	PUNCT
ajlm-801	94	8	becq	becq	PROPN
ajlm-801	94	9	j	j	PROPN
ajlm-801	94	10	,	,	PUNCT
ajlm-801	94	11	et	et	PROPN
ajlm-801	94	12	al	al	PROPN
ajlm-801	94	13	.	.	PUNCT
ajlm-801	95	1	whole	whole	ADJ
ajlm-801	95	2	-	-	PUNCT
ajlm-801	95	3	genome	genome	NOUN
ajlm-801	95	4	sequencing	sequencing	NOUN
ajlm-801	95	5	for	for	ADP
ajlm-801	95	6	rapid	rapid	ADJ
ajlm-801	95	7	susceptibility	susceptibility	NOUN
ajlm-801	95	8	testing	testing	NOUN
ajlm-801	95	9	of	of	ADP
ajlm-801	95	10	m.	m.	NOUN
ajlm-801	95	11	tuberculosis	tuberculosis	NOUN
ajlm-801	95	12	.	.	PUNCT
ajlm-801	96	1	n	n	PROPN
ajlm-801	96	2	engl	engl	PROPN
ajlm-801	96	3	j	j	PROPN
ajlm-801	96	4	med	med	PROPN
ajlm-801	96	5	.	.	PUNCT
ajlm-801	97	1	2013;369(3):290–292	2013;369(3):290–292	X
ajlm-801	97	2	.	.	PUNCT
ajlm-801	97	3	https://doi.org/10.1056/nejmc1215305	https://doi.org/10.1056/nejmc1215305	PROPN
ajlm-801	97	4	walker	walker	PROPN
ajlm-801	97	5	tm	tm	PROPN
ajlm-801	97	6	,	,	PUNCT
ajlm-801	97	7	merker	merker	NOUN
ajlm-801	97	8	m	m	PROPN
ajlm-801	97	9	,	,	PUNCT
ajlm-801	97	10	kohl	kohl	PROPN
ajlm-801	97	11	ta	ta	PROPN
ajlm-801	97	12	,	,	PUNCT
ajlm-801	97	13	crook	crook	PROPN
ajlm-801	97	14	dw	dw	PROPN
ajlm-801	97	15	,	,	PUNCT
ajlm-801	97	16	niemann	niemann	PROPN
ajlm-801	97	17	s	s	PROPN
ajlm-801	97	18	,	,	PUNCT
ajlm-801	97	19	peto	peto	VERB
ajlm-801	97	20	te	te	PROPN
ajlm-801	97	21	.	.	PUNCT
ajlm-801	98	1	whole	whole	ADJ
ajlm-801	98	2	genome	genome	NOUN
ajlm-801	98	3	sequencing	sequencing	NOUN
ajlm-801	98	4	for	for	ADP
ajlm-801	98	5	m	m	PROPN
ajlm-801	98	6	/	/	SYM
ajlm-801	98	7	xdr	xdr	PROPN
ajlm-801	98	8	tuberculosis	tuberculosis	NOUN
ajlm-801	98	9	surveillance	surveillance	NOUN
ajlm-801	98	10	and	and	CCONJ
ajlm-801	98	11	for	for	ADP
ajlm-801	98	12	resistance	resistance	NOUN
ajlm-801	98	13	testing	testing	NOUN
ajlm-801	98	14	.	.	PUNCT
ajlm-801	99	1	clin	clin	PROPN
ajlm-801	99	2	microbiol	microbiol	PROPN
ajlm-801	99	3	infect	infect	VERB
ajlm-801	99	4	.	.	PUNCT
ajlm-801	100	1	2017;23(3):161–166	2017;23(3):161–166	X
ajlm-801	100	2	.	.	PROPN
ajlm-801	100	3	https://doi.org/10.1016/j.cmi.2016.10.014	https://doi.org/10.1016/j.cmi.2016.10.014	PROPN
ajlm-801	100	4	drobniewski	drobniewski	PROPN
ajlm-801	100	5	f	f	X
ajlm-801	100	6	,	,	PUNCT
ajlm-801	100	7	nikolayevskyy	nikolayevskyy	ADJ
ajlm-801	100	8	v	v	NOUN
ajlm-801	100	9	,	,	PUNCT
ajlm-801	100	10	maxeiner	maxeiner	NOUN
ajlm-801	100	11	h	h	PROPN
ajlm-801	100	12	,	,	PUNCT
ajlm-801	100	13	et	et	PROPN
ajlm-801	100	14	al	al	PROPN
ajlm-801	100	15	.	.	PROPN
ajlm-801	101	1	rapid	rapid	ADJ
ajlm-801	101	2	diagnostics	diagnostic	NOUN
ajlm-801	101	3	of	of	ADP
ajlm-801	101	4	tuberculosis	tuberculosis	NOUN
ajlm-801	101	5	and	and	CCONJ
ajlm-801	101	6	drug	drug	NOUN
ajlm-801	101	7	resistance	resistance	NOUN
ajlm-801	101	8	in	in	ADP
ajlm-801	101	9	the	the	DET
ajlm-801	101	10	industrialized	industrialized	ADJ
ajlm-801	101	11	world	world	NOUN
ajlm-801	101	12	:	:	PUNCT
ajlm-801	101	13	clinical	clinical	ADJ
ajlm-801	101	14	and	and	CCONJ
ajlm-801	101	15	public	public	ADJ
ajlm-801	101	16	health	health	NOUN
ajlm-801	101	17	benefits	benefit	NOUN
ajlm-801	101	18	and	and	CCONJ
ajlm-801	101	19	barriers	barrier	NOUN
ajlm-801	101	20	to	to	ADP
ajlm-801	101	21	implementation	implementation	NOUN
ajlm-801	101	22	.	.	PUNCT
ajlm-801	102	1	bmc	bmc	PROPN
ajlm-801	102	2	med	med	PROPN
ajlm-801	102	3	.	.	PUNCT
ajlm-801	103	1	2013;11:190	2013;11:190	X
ajlm-801	103	2	.	.	PUNCT
ajlm-801	104	1	https://doi.org/10.1186/1741-7015-11-190	https://doi.org/10.1186/1741-7015-11-190	PROPN
ajlm-801	104	2	hartkoorn	hartkoorn	PROPN
ajlm-801	104	3	rc	rc	PROPN
ajlm-801	104	4	,	,	PUNCT
ajlm-801	104	5	uplekar	uplekar	PROPN
ajlm-801	104	6	s	s	PROPN
ajlm-801	104	7	,	,	PUNCT
ajlm-801	104	8	cole	cole	PROPN
ajlm-801	104	9	st	st	PROPN
ajlm-801	104	10	.	.	PROPN
ajlm-801	104	11	cross	cross	PROPN
ajlm-801	104	12	-	-	NOUN
ajlm-801	104	13	resistance	resistance	NOUN
ajlm-801	104	14	between	between	ADP
ajlm-801	104	15	clofazimine	clofazimine	NOUN
ajlm-801	104	16	and	and	CCONJ
ajlm-801	104	17	bedaquiline	bedaquiline	NOUN
ajlm-801	104	18	through	through	ADP
ajlm-801	104	19	upregulation	upregulation	NOUN
ajlm-801	104	20	of	of	ADP
ajlm-801	104	21	mmpl5	mmpl5	NOUN
ajlm-801	104	22	in	in	ADP
ajlm-801	104	23	mycobacterium	mycobacterium	NOUN
ajlm-801	104	24	tuberculosis	tuberculosis	NOUN
ajlm-801	104	25	.	.	PUNCT
ajlm-801	105	1	antimicrob	antimicrob	PROPN
ajlm-801	105	2	agents	agents	PROPN
ajlm-801	105	3	chemother	chemother	PROPN
ajlm-801	105	4	.	.	PUNCT
ajlm-801	106	1	2014;58(5):2979–2981	2014;58(5):2979–2981	NOUN
ajlm-801	106	2	.	.	PUNCT
ajlm-801	107	1	https://doi.org/10.1128/aac.00037-14	https://doi.org/10.1128/aac.00037-14	PROPN
ajlm-801	107	2	lee	lee	PROPN
ajlm-801	107	3	rs	rs	PROPN
ajlm-801	107	4	,	,	PUNCT
ajlm-801	107	5	behr	behr	PROPN
ajlm-801	107	6	ma	ma	PROPN
ajlm-801	107	7	.	.	PUNCT
ajlm-801	108	1	the	the	DET
ajlm-801	108	2	implications	implication	NOUN
ajlm-801	108	3	of	of	ADP
ajlm-801	108	4	whole	whole	ADJ
ajlm-801	108	5	-	-	PUNCT
ajlm-801	108	6	genome	genome	NOUN
ajlm-801	108	7	sequencing	sequencing	NOUN
ajlm-801	108	8	in	in	ADP
ajlm-801	108	9	the	the	DET
ajlm-801	108	10	control	control	NOUN
ajlm-801	108	11	of	of	ADP
ajlm-801	108	12	tuberculosis	tuberculosis	NOUN
ajlm-801	108	13	.	.	PUNCT
ajlm-801	109	1	ther	ther	VERB
ajlm-801	109	2	adv	adv	PROPN
ajlm-801	109	3	infect	infect	VERB
ajlm-801	109	4	dis	dis	PROPN
ajlm-801	109	5	.	.	PUNCT
ajlm-801	110	1	2016;3(2):47–62	2016;3(2):47–62	NUM
ajlm-801	110	2	.	.	X
ajlm-801	111	1	https://doi.org/10.1177/2049936115624630	https://doi.org/10.1177/2049936115624630	PROPN
ajlm-801	111	2	initiative	initiative	NOUN
ajlm-801	111	3	gl	gl	PROPN
ajlm-801	111	4	.	.	PROPN
ajlm-801	111	5	global	global	ADJ
ajlm-801	111	6	laboratory	laboratory	PROPN
ajlm-801	111	7	initiative	initiative	NOUN
ajlm-801	111	8	,	,	PUNCT
ajlm-801	111	9	editor	editor	NOUN
ajlm-801	111	10	.	.	PUNCT
ajlm-801	112	1	mycobacteriology	mycobacteriology	NOUN
ajlm-801	112	2	laboratory	laboratory	PROPN
ajlm-801	112	3	mannual	mannual	PROPN
ajlm-801	112	4	[	[	X
ajlm-801	112	5	homepage	homepage	NOUN
ajlm-801	112	6	on	on	ADP
ajlm-801	112	7	the	the	DET
ajlm-801	112	8	internet	internet	NOUN
ajlm-801	112	9	]	]	PUNCT
ajlm-801	112	10	.	.	PUNCT
ajlm-801	113	1	1st	1st	ADJ
ajlm-801	113	2	ed	ed	NOUN
ajlm-801	113	3	.	.	PUNCT
ajlm-801	114	1	geneva	geneva	PROPN
ajlm-801	114	2	,	,	PUNCT
ajlm-801	114	3	switzeland	switzeland	NOUN
ajlm-801	114	4	:	:	PUNCT
ajlm-801	114	5	who	who	PRON
ajlm-801	114	6	press	press	VERB
ajlm-801	114	7	;	;	PUNCT
ajlm-801	114	8	2014	2014	NUM
ajlm-801	114	9	[	[	X
ajlm-801	114	10	cited	cite	VERB
ajlm-801	114	11	2015	2015	NUM
ajlm-801	114	12	may	may	AUX
ajlm-801	114	13	25	25	NUM
ajlm-801	114	14	]	]	PUNCT
ajlm-801	114	15	.	.	PUNCT
ajlm-801	115	1	available	available	ADJ
ajlm-801	115	2	from	from	ADP
ajlm-801	115	3	:	:	PUNCT
ajlm-801	115	4	http://www.stoptb.org/wg/gli/assets/documents/gli_mycobacteriology_lab_manual_web.pdf	http://www.stoptb.org/wg/gli/assets/documents/gli_mycobacteriology_lab_manual_web.pdf	PROPN
ajlm-801	115	5	who	who	PRON
ajlm-801	115	6	.	.	PUNCT
ajlm-801	116	1	updated	update	VERB
ajlm-801	116	2	interim	interim	ADJ
ajlm-801	116	3	critical	critical	ADJ
ajlm-801	116	4	concentrations	concentration	NOUN
ajlm-801	116	5	for	for	ADP
ajlm-801	116	6	first	first	ADJ
ajlm-801	116	7	-	-	PUNCT
ajlm-801	116	8	line	line	NOUN
ajlm-801	116	9	and	and	CCONJ
ajlm-801	116	10	second	second	ADJ
ajlm-801	116	11	-	-	PUNCT
ajlm-801	116	12	line	line	NOUN
ajlm-801	116	13	dst	dst	NOUN
ajlm-801	116	14	(	(	PUNCT
ajlm-801	116	15	as	as	ADP
ajlm-801	116	16	of	of	ADP
ajlm-801	116	17	may	may	PROPN
ajlm-801	116	18	2012	2012	NUM
ajlm-801	116	19	)	)	PUNCT
ajlm-801	117	1	[	[	X
ajlm-801	117	2	homepage	homepage	NOUN
ajlm-801	117	3	on	on	ADP
ajlm-801	117	4	the	the	DET
ajlm-801	117	5	internet	internet	NOUN
ajlm-801	117	6	]	]	PUNCT
ajlm-801	117	7	.	.	PUNCT
ajlm-801	118	1	2012	2012	NUM
ajlm-801	119	1	[	[	X
ajlm-801	119	2	cited	cite	VERB
ajlm-801	119	3	2012	2012	NUM
ajlm-801	119	4	may	may	AUX
ajlm-801	119	5	]	]	PUNCT
ajlm-801	119	6	.	.	PUNCT
ajlm-801	120	1	available	available	ADJ
ajlm-801	120	2	from	from	ADP
ajlm-801	120	3	:	:	PUNCT
ajlm-801	120	4	http://apps.who.int/iris/bitstream/10665/259366/1/9789241565516-eng.pdf?ua=1	http://apps.who.int/iris/bitstream/10665/259366/1/9789241565516-eng.pdf?ua=1	NOUN
ajlm-801	120	5	farhat	farhat	PROPN
ajlm-801	120	6	mr	mr	PROPN
ajlm-801	120	7	,	,	PUNCT
ajlm-801	120	8	shapiro	shapiro	PROPN
ajlm-801	120	9	bj	bj	PROPN
ajlm-801	120	10	,	,	PUNCT
ajlm-801	120	11	kieser	kieser	NOUN
ajlm-801	120	12	kj	kj	PROPN
ajlm-801	120	13	,	,	PUNCT
ajlm-801	120	14	et	et	PROPN
ajlm-801	120	15	al	al	PROPN
ajlm-801	120	16	.	.	PUNCT
ajlm-801	121	1	genomic	genomic	ADJ
ajlm-801	121	2	analysis	analysis	NOUN
ajlm-801	121	3	identifies	identify	VERB
ajlm-801	121	4	targets	target	NOUN
ajlm-801	121	5	of	of	ADP
ajlm-801	121	6	convergent	convergent	ADJ
ajlm-801	121	7	positive	positive	ADJ
ajlm-801	121	8	selection	selection	NOUN
ajlm-801	121	9	in	in	ADP
ajlm-801	121	10	drug	drug	NOUN
ajlm-801	121	11	-	-	PUNCT
ajlm-801	121	12	resistant	resistant	ADJ
ajlm-801	121	13	mycobacterium	mycobacterium	NOUN
ajlm-801	121	14	tuberculosis	tuberculosis	NOUN
ajlm-801	121	15	.	.	PUNCT
ajlm-801	122	1	nat	nat	PROPN
ajlm-801	122	2	genet	genet	PROPN
ajlm-801	122	3	.	.	PUNCT
ajlm-801	123	1	2013;45(10):1183–1189	2013;45(10):1183–1189	NUM
ajlm-801	123	2	.	.	PUNCT
ajlm-801	124	1	https://doi.org/10.1038/ng.2747	https://doi.org/10.1038/ng.2747	PROPN
ajlm-801	124	2	sandgren	sandgren	PROPN
ajlm-801	124	3	a	a	PRON
ajlm-801	124	4	,	,	PUNCT
ajlm-801	124	5	strong	strong	ADJ
ajlm-801	124	6	m	m	PROPN
ajlm-801	124	7	,	,	PUNCT
ajlm-801	124	8	muthukrishnan	muthukrishnan	PROPN
ajlm-801	124	9	p	p	NOUN
ajlm-801	124	10	,	,	PUNCT
ajlm-801	124	11	weiner	weiner	NOUN
ajlm-801	124	12	bk	bk	PROPN
ajlm-801	124	13	,	,	PUNCT
ajlm-801	124	14	church	church	NOUN
ajlm-801	124	15	gm	gm	PROPN
ajlm-801	124	16	,	,	PUNCT
ajlm-801	124	17	murray	murray	PROPN
ajlm-801	124	18	mb	mb	PROPN
ajlm-801	124	19	.	.	PROPN
ajlm-801	125	1	tuberculosis	tuberculosis	NOUN
ajlm-801	125	2	drug	drug	NOUN
ajlm-801	125	3	resistance	resistance	NOUN
ajlm-801	125	4	mutation	mutation	NOUN
ajlm-801	125	5	database	database	NOUN
ajlm-801	125	6	.	.	PUNCT
ajlm-801	126	1	plos	plos	PROPN
ajlm-801	126	2	med	med	PROPN
ajlm-801	126	3	.	.	PUNCT
ajlm-801	127	1	2009;6(2):e2	2009;6(2):e2	NUM
ajlm-801	127	2	.	.	PUNCT
ajlm-801	128	1	https://doi.org/10.1371/journal.pmed.1000002	https://doi.org/10.1371/journal.pmed.1000002	PROPN
ajlm-801	128	2	feuerriegel	feuerriegel	NOUN
ajlm-801	128	3	s	s	PART
ajlm-801	128	4	,	,	PUNCT
ajlm-801	128	5	schleusener	schleusener	NOUN
ajlm-801	128	6	v	v	NOUN
ajlm-801	128	7	,	,	PUNCT
ajlm-801	128	8	beckert	beckert	NOUN
ajlm-801	128	9	p	p	NOUN
ajlm-801	128	10	,	,	PUNCT
ajlm-801	129	1	et	et	PROPN
ajlm-801	129	2	al	al	PROPN
ajlm-801	129	3	.	.	PROPN
ajlm-801	129	4	phyresse	phyresse	PROPN
ajlm-801	129	5	:	:	PUNCT
ajlm-801	130	1	a	a	DET
ajlm-801	130	2	web	web	NOUN
ajlm-801	130	3	tool	tool	NOUN
ajlm-801	130	4	delineating	delineate	VERB
ajlm-801	130	5	mycobacterium	mycobacterium	NOUN
ajlm-801	130	6	tuberculosis	tuberculosis	NOUN
ajlm-801	130	7	antibiotic	antibiotic	ADJ
ajlm-801	130	8	resistance	resistance	NOUN
ajlm-801	130	9	and	and	CCONJ
ajlm-801	130	10	lineage	lineage	NOUN
ajlm-801	130	11	from	from	ADP
ajlm-801	130	12	whole	whole	ADJ
ajlm-801	130	13	-	-	PUNCT
ajlm-801	130	14	genome	genome	NOUN
ajlm-801	130	15	sequencing	sequence	VERB
ajlm-801	130	16	data	datum	NOUN
ajlm-801	130	17	.	.	PUNCT
ajlm-801	131	1	j	j	PROPN
ajlm-801	131	2	clin	clin	PROPN
ajlm-801	131	3	microbiol	microbiol	PROPN
ajlm-801	131	4	.	.	PUNCT
ajlm-801	132	1	2015;53(6):1908–1914	2015;53(6):1908–1914	PROPN
ajlm-801	132	2	.	.	PUNCT
ajlm-801	133	1	https://doi.org/10.1128/jcm.00025-15	https://doi.org/10.1128/jcm.00025-15	PROPN
ajlm-801	133	2	coll	coll	PROPN
ajlm-801	133	3	f	f	PROPN
ajlm-801	133	4	,	,	PUNCT
ajlm-801	133	5	mcnerney	mcnerney	PROPN
ajlm-801	133	6	r	r	PROPN
ajlm-801	133	7	,	,	PUNCT
ajlm-801	133	8	preston	preston	PROPN
ajlm-801	133	9	md	md	PROPN
ajlm-801	133	10	,	,	PUNCT
ajlm-801	133	11	et	et	PROPN
ajlm-801	133	12	al	al	PROPN
ajlm-801	133	13	.	.	PROPN
ajlm-801	134	1	rapid	rapid	ADJ
ajlm-801	134	2	determination	determination	NOUN
ajlm-801	134	3	of	of	ADP
ajlm-801	134	4	anti	anti	ADJ
ajlm-801	134	5	-	-	ADJ
ajlm-801	134	6	tuberculosis	tuberculosis	ADJ
ajlm-801	134	7	drug	drug	NOUN
ajlm-801	134	8	resistance	resistance	NOUN
ajlm-801	134	9	from	from	ADP
ajlm-801	134	10	whole	whole	ADJ
ajlm-801	134	11	-	-	PUNCT
ajlm-801	134	12	genome	genome	NOUN
ajlm-801	134	13	sequences	sequence	NOUN
ajlm-801	134	14	.	.	PUNCT
ajlm-801	135	1	genome	genome	NOUN
ajlm-801	135	2	med	me	VERB
ajlm-801	135	3	.	.	PUNCT
ajlm-801	136	1	2015;7(1):51	2015;7(1):51	NUM
ajlm-801	136	2	.	.	PUNCT
ajlm-801	136	3	https://doi.org/10.1186/s13073-015-0164-0	https://doi.org/10.1186/s13073-015-0164-0	NUM
ajlm-801	136	4	feuerriegel	feuerriegel	NOUN
ajlm-801	136	5	s	s	PART
ajlm-801	136	6	,	,	PUNCT
ajlm-801	136	7	koser	koser	PROPN
ajlm-801	136	8	cu	cu	PROPN
ajlm-801	136	9	,	,	PUNCT
ajlm-801	136	10	bau	bau	PROPN
ajlm-801	136	11	d	d	PROPN
ajlm-801	136	12	,	,	PUNCT
ajlm-801	136	13	et	et	PROPN
ajlm-801	136	14	al	al	PROPN
ajlm-801	136	15	.	.	PROPN
ajlm-801	136	16	impact	impact	NOUN
ajlm-801	136	17	of	of	ADP
ajlm-801	136	18	fgd1	fgd1	PROPN
ajlm-801	136	19	and	and	CCONJ
ajlm-801	136	20	ddn	ddn	NOUN
ajlm-801	136	21	diversity	diversity	NOUN
ajlm-801	136	22	in	in	ADP
ajlm-801	136	23	mycobacterium	mycobacterium	NOUN
ajlm-801	136	24	tuberculosis	tuberculosis	NOUN
ajlm-801	136	25	complex	complex	NOUN
ajlm-801	136	26	on	on	ADV
ajlm-801	136	27	in	in	ADP
ajlm-801	136	28	vitro	vitro	X
ajlm-801	136	29	susceptibility	susceptibility	NOUN
ajlm-801	136	30	to	to	ADP
ajlm-801	136	31	pa-824	pa-824	PROPN
ajlm-801	136	32	.	.	PUNCT
ajlm-801	137	1	antimicrob	antimicrob	PROPN
ajlm-801	137	2	agents	agents	PROPN
ajlm-801	137	3	chemother	chemother	PROPN
ajlm-801	137	4	.	.	PUNCT
ajlm-801	138	1	2011;55(12):5718–5722	2011;55(12):5718–5722	X
ajlm-801	138	2	.	.	PUNCT
ajlm-801	139	1	https://doi.org/10.1128/aac.05500-11	https://doi.org/10.1128/aac.05500-11	PROPN
ajlm-801	139	2	andre	andre	PROPN
ajlm-801	139	3	e	e	PROPN
ajlm-801	139	4	,	,	PUNCT
ajlm-801	139	5	goeminne	goeminne	PROPN
ajlm-801	139	6	l	l	PROPN
ajlm-801	139	7	,	,	PUNCT
ajlm-801	139	8	cabibbe	cabibbe	NOUN
ajlm-801	139	9	a	a	X
ajlm-801	139	10	,	,	PUNCT
ajlm-801	139	11	et	et	PROPN
ajlm-801	139	12	al	al	PROPN
ajlm-801	139	13	.	.	PUNCT
ajlm-801	140	1	consensus	consensus	NOUN
ajlm-801	140	2	numbering	number	VERB
ajlm-801	140	3	system	system	NOUN
ajlm-801	140	4	for	for	ADP
ajlm-801	140	5	the	the	DET
ajlm-801	140	6	rifampicin	rifampicin	VERB
ajlm-801	140	7	resistance	resistance	NOUN
ajlm-801	140	8	-	-	PUNCT
ajlm-801	140	9	associated	associate	VERB
ajlm-801	140	10	rpob	rpob	ADJ
ajlm-801	140	11	gene	gene	NOUN
ajlm-801	140	12	mutations	mutation	NOUN
ajlm-801	140	13	in	in	ADP
ajlm-801	140	14	pathogenic	pathogenic	ADJ
ajlm-801	140	15	mycobacteria	mycobacterium	NOUN
ajlm-801	140	16	.	.	PUNCT
ajlm-801	141	1	clin	clin	PROPN
ajlm-801	141	2	microbiol	microbiol	PROPN
ajlm-801	141	3	infect	infect	VERB
ajlm-801	141	4	.	.	PUNCT
ajlm-801	142	1	2017;23(3):167–172	2017;23(3):167–172	NUM
ajlm-801	142	2	.	.	PUNCT
ajlm-801	143	1	https://doi.org/10.1016/j.cmi.2016.09.006	https://doi.org/10.1016/j.cmi.2016.09.006	PROPN
ajlm-801	143	2	hall	hall	PROPN
ajlm-801	143	3	l	l	PROPN
ajlm-801	143	4	,	,	PUNCT
ajlm-801	143	5	jude	jude	PROPN
ajlm-801	143	6	kp	kp	PROPN
ajlm-801	143	7	,	,	PUNCT
ajlm-801	143	8	clark	clark	PROPN
ajlm-801	143	9	sl	sl	PROPN
ajlm-801	143	10	,	,	PUNCT
ajlm-801	143	11	et	et	PROPN
ajlm-801	143	12	al	al	PROPN
ajlm-801	143	13	.	.	PUNCT
ajlm-801	143	14	evaluation	evaluation	NOUN
ajlm-801	143	15	of	of	ADP
ajlm-801	143	16	the	the	DET
ajlm-801	143	17	sensititre	sensititre	NOUN
ajlm-801	143	18	mycotb	mycotb	PROPN
ajlm-801	143	19	plate	plate	NOUN
ajlm-801	143	20	for	for	ADP
ajlm-801	143	21	susceptibility	susceptibility	NOUN
ajlm-801	143	22	testing	testing	NOUN
ajlm-801	143	23	of	of	ADP
ajlm-801	143	24	the	the	DET
ajlm-801	143	25	mycobacterium	mycobacterium	NOUN
ajlm-801	143	26	tuberculosis	tuberculosis	NOUN
ajlm-801	143	27	complex	complex	NOUN
ajlm-801	143	28	against	against	ADP
ajlm-801	143	29	firstand	firstand	NOUN
ajlm-801	143	30	second	second	ADJ
ajlm-801	143	31	-	-	PUNCT
ajlm-801	143	32	line	line	NOUN
ajlm-801	143	33	agents	agent	NOUN
ajlm-801	143	34	.	.	PUNCT
ajlm-801	144	1	j	j	PROPN
ajlm-801	144	2	clin	clin	PROPN
ajlm-801	144	3	microbiol	microbiol	PROPN
ajlm-801	144	4	.	.	PUNCT
ajlm-801	145	1	2012;50(11):3732–3734	2012;50(11):3732–3734	NUM
ajlm-801	145	2	.	.	PUNCT
ajlm-801	146	1	https://doi.org/10.1128/jcm.02048-12	https://doi.org/10.1128/jcm.02048-12	VERB
ajlm-801	146	2	singh	singh	PROPN
ajlm-801	146	3	p	p	NOUN
ajlm-801	146	4	,	,	PUNCT
ajlm-801	146	5	wesley	wesley	PROPN
ajlm-801	146	6	c	c	NOUN
ajlm-801	146	7	,	,	PUNCT
ajlm-801	146	8	jadaun	jadaun	ADJ
ajlm-801	146	9	gp	gp	NOUN
ajlm-801	146	10	,	,	PUNCT
ajlm-801	146	11	et	et	PROPN
ajlm-801	146	12	al	al	PROPN
ajlm-801	146	13	.	.	PROPN
ajlm-801	147	1	comparative	comparative	ADJ
ajlm-801	147	2	evaluation	evaluation	NOUN
ajlm-801	147	3	of	of	ADP
ajlm-801	147	4	lowenstein	lowenstein	PROPN
ajlm-801	147	5	-	-	PUNCT
ajlm-801	147	6	jensen	jensen	PROPN
ajlm-801	147	7	proportion	proportion	NOUN
ajlm-801	147	8	method	method	NOUN
ajlm-801	147	9	,	,	PUNCT
ajlm-801	147	10	bact	bact	NOUN
ajlm-801	147	11	/	/	SYM
ajlm-801	147	12	alert	alert	ADJ
ajlm-801	147	13	3d	3d	NUM
ajlm-801	147	14	system	system	NOUN
ajlm-801	147	15	,	,	PUNCT
ajlm-801	147	16	and	and	CCONJ
ajlm-801	147	17	enzymatic	enzymatic	ADJ
ajlm-801	147	18	pyrazinamidase	pyrazinamidase	NOUN
ajlm-801	147	19	assay	assay	NOUN
ajlm-801	147	20	for	for	ADP
ajlm-801	147	21	pyrazinamide	pyrazinamide	NOUN
ajlm-801	147	22	susceptibility	susceptibility	NOUN
ajlm-801	147	23	testing	testing	NOUN
ajlm-801	147	24	of	of	ADP
ajlm-801	147	25	mycobacterium	mycobacterium	NOUN
ajlm-801	147	26	tuberculosis	tuberculosis	NOUN
ajlm-801	147	27	.	.	PUNCT
ajlm-801	148	1	j	j	PROPN
ajlm-801	148	2	clin	clin	PROPN
ajlm-801	148	3	microbiol	microbiol	PROPN
ajlm-801	148	4	.	.	PUNCT
ajlm-801	149	1	2007;45(1):76–80	2007;45(1):76–80	NUM
ajlm-801	149	2	.	.	PUNCT
ajlm-801	150	1	https://doi.org/10.1128/jcm.00951-06	https://doi.org/10.1128/jcm.00951-06	PROPN
ajlm-801	150	2	walker	walker	PROPN
ajlm-801	150	3	tm	tm	PROPN
ajlm-801	150	4	,	,	PUNCT
ajlm-801	150	5	kohl	kohl	PROPN
ajlm-801	150	6	ta	ta	PROPN
ajlm-801	150	7	,	,	PUNCT
ajlm-801	150	8	omar	omar	PROPN
ajlm-801	150	9	sv	sv	PROPN
ajlm-801	150	10	,	,	PUNCT
ajlm-801	150	11	et	et	PROPN
ajlm-801	150	12	al	al	PROPN
ajlm-801	150	13	.	.	PUNCT
ajlm-801	151	1	whole	whole	ADJ
ajlm-801	151	2	-	-	PUNCT
ajlm-801	151	3	genome	genome	NOUN
ajlm-801	151	4	sequencing	sequencing	NOUN
ajlm-801	151	5	for	for	ADP
ajlm-801	151	6	prediction	prediction	NOUN
ajlm-801	151	7	of	of	ADP
ajlm-801	151	8	mycobacterium	mycobacterium	NOUN
ajlm-801	151	9	tuberculosis	tuberculosis	NOUN
ajlm-801	151	10	drug	drug	NOUN
ajlm-801	151	11	susceptibility	susceptibility	NOUN
ajlm-801	151	12	and	and	CCONJ
ajlm-801	151	13	resistance	resistance	NOUN
ajlm-801	151	14	:	:	PUNCT
ajlm-801	151	15	a	a	DET
ajlm-801	151	16	retrospective	retrospective	ADJ
ajlm-801	151	17	cohort	cohort	NOUN
ajlm-801	151	18	study	study	NOUN
ajlm-801	151	19	.	.	PUNCT
ajlm-801	152	1	lancet	lancet	PROPN
ajlm-801	152	2	infect	infect	PROPN
ajlm-801	152	3	dis	dis	PROPN
ajlm-801	152	4	.	.	PUNCT
ajlm-801	153	1	2015;15(10):1193–1202	2015;15(10):1193–1202	X
ajlm-801	153	2	.	.	PUNCT
ajlm-801	154	1	https://doi.org/10.1016/s1473-3099(15)00062-6	https://doi.org/10.1016/s1473-3099(15)00062-6	PROPN
ajlm-801	154	2	louw	louw	PROPN
ajlm-801	154	3	ge	ge	PROPN
ajlm-801	154	4	,	,	PUNCT
ajlm-801	154	5	warren	warren	PROPN
ajlm-801	154	6	rm	rm	PROPN
ajlm-801	154	7	,	,	PUNCT
ajlm-801	154	8	donald	donald	PROPN
ajlm-801	154	9	pr	pr	PROPN
ajlm-801	154	10	,	,	PUNCT
ajlm-801	154	11	et	et	PROPN
ajlm-801	154	12	al	al	PROPN
ajlm-801	154	13	.	.	PROPN
ajlm-801	154	14	frequency	frequency	PROPN
ajlm-801	154	15	and	and	CCONJ
ajlm-801	154	16	implications	implication	NOUN
ajlm-801	154	17	of	of	ADP
ajlm-801	154	18	pyrazinamide	pyrazinamide	ADJ
ajlm-801	154	19	resistance	resistance	NOUN
ajlm-801	154	20	in	in	ADP
ajlm-801	154	21	managing	manage	VERB
ajlm-801	154	22	previously	previously	ADV
ajlm-801	154	23	treated	treat	VERB
ajlm-801	154	24	tuberculosis	tuberculosis	NOUN
ajlm-801	154	25	patients	patient	NOUN
ajlm-801	154	26	.	.	PUNCT
ajlm-801	155	1	int	int	NOUN
ajlm-801	155	2	j	j	PROPN
ajlm-801	155	3	tuberc	tuberc	PROPN
ajlm-801	155	4	lung	lung	PROPN
ajlm-801	155	5	dis	dis	PROPN
ajlm-801	155	6	.	.	PUNCT
ajlm-801	156	1	2006;10(7):802–807	2006;10(7):802–807	X
ajlm-801	156	2	.	.	PROPN
ajlm-801	156	3	huitric	huitric	PROPN
ajlm-801	156	4	e	e	PROPN
ajlm-801	156	5	,	,	PUNCT
ajlm-801	156	6	verhasselt	verhasselt	VERB
ajlm-801	156	7	p	p	NOUN
ajlm-801	156	8	,	,	PUNCT
ajlm-801	157	1	koul	koul	PROPN
ajlm-801	157	2	a	a	X
ajlm-801	157	3	,	,	PUNCT
ajlm-801	157	4	andries	andries	PROPN
ajlm-801	157	5	k	k	PROPN
ajlm-801	157	6	,	,	PUNCT
ajlm-801	157	7	hoffner	hoffner	ADP
ajlm-801	157	8	s	s	PROPN
ajlm-801	157	9	,	,	PUNCT
ajlm-801	157	10	andersson	andersson	PROPN
ajlm-801	157	11	di	di	PROPN
ajlm-801	157	12	.	.	PROPN
ajlm-801	157	13	rates	rate	NOUN
ajlm-801	157	14	and	and	CCONJ
ajlm-801	157	15	mechanisms	mechanism	NOUN
ajlm-801	157	16	of	of	ADP
ajlm-801	157	17	resistance	resistance	NOUN
ajlm-801	157	18	development	development	NOUN
ajlm-801	157	19	in	in	ADP
ajlm-801	157	20	mycobacterium	mycobacterium	NOUN
ajlm-801	157	21	tuberculosis	tuberculosis	NOUN
ajlm-801	157	22	to	to	ADP
ajlm-801	157	23	a	a	DET
ajlm-801	157	24	novel	novel	ADJ
ajlm-801	157	25	diarylquinoline	diarylquinoline	NOUN
ajlm-801	157	26	atp	atp	NOUN
ajlm-801	157	27	synthase	synthase	NOUN
ajlm-801	157	28	inhibitor	inhibitor	NOUN
ajlm-801	157	29	.	.	PUNCT
ajlm-801	158	1	antimicrob	antimicrob	PROPN
ajlm-801	158	2	agents	agents	PROPN
ajlm-801	158	3	chemother	chemother	PROPN
ajlm-801	158	4	.	.	PUNCT
ajlm-801	159	1	2010;54(3):1022–1028	2010;54(3):1022–1028	NUM
ajlm-801	159	2	.	.	PUNCT
ajlm-801	160	1	https://doi.org/10.1128/aac.01611-09	https://doi.org/10.1128/aac.01611-09	PROPN
ajlm-801	160	2	zignol	zignol	NOUN
ajlm-801	160	3	m	m	PROPN
ajlm-801	160	4	,	,	PUNCT
ajlm-801	160	5	cabibbe	cabibbe	NOUN
ajlm-801	160	6	am	be	AUX
ajlm-801	160	7	,	,	PUNCT
ajlm-801	160	8	dean	dean	ADJ
ajlm-801	160	9	as	as	ADP
ajlm-801	160	10	,	,	PUNCT
ajlm-801	160	11	et	et	PROPN
ajlm-801	160	12	al	al	PROPN
ajlm-801	160	13	.	.	PUNCT
ajlm-801	161	1	genetic	genetic	ADJ
ajlm-801	161	2	sequencing	sequencing	NOUN
ajlm-801	161	3	for	for	ADP
ajlm-801	161	4	surveillance	surveillance	NOUN
ajlm-801	161	5	of	of	ADP
ajlm-801	161	6	drug	drug	NOUN
ajlm-801	161	7	resistance	resistance	NOUN
ajlm-801	161	8	in	in	ADP
ajlm-801	161	9	tuberculosis	tuberculosis	NOUN
ajlm-801	161	10	in	in	ADP
ajlm-801	161	11	highly	highly	ADV
ajlm-801	161	12	endemic	endemic	ADJ
ajlm-801	161	13	countries	country	NOUN
ajlm-801	161	14	:	:	PUNCT
ajlm-801	161	15	a	a	DET
ajlm-801	161	16	multi	multi	ADJ
ajlm-801	161	17	-	-	ADJ
ajlm-801	161	18	country	country	ADJ
ajlm-801	161	19	population	population	NOUN
ajlm-801	161	20	-	-	PUNCT
ajlm-801	161	21	based	base	VERB
ajlm-801	161	22	surveillance	surveillance	NOUN
ajlm-801	161	23	study	study	NOUN
ajlm-801	161	24	.	.	PUNCT
ajlm-801	162	1	lancet	lancet	PROPN
ajlm-801	162	2	infect	infect	PROPN
ajlm-801	162	3	dis	dis	PROPN
ajlm-801	162	4	.	.	PUNCT
ajlm-801	163	1	2018;18(6):675–683	2018;18(6):675–683	NUM
ajlm-801	163	2	.	.	PUNCT
ajlm-801	164	1	https://doi.org/10.1016/s1473-3099(18)30073-2	https://doi.org/10.1016/s1473-3099(18)30073-2	PROPN
ajlm-801	164	2	loman	loman	PROPN
ajlm-801	164	3	nj	nj	PROPN
ajlm-801	164	4	,	,	PUNCT
ajlm-801	164	5	constantinidou	constantinidou	NOUN
ajlm-801	164	6	c	c	PROPN
ajlm-801	164	7	,	,	PUNCT
ajlm-801	164	8	chan	chan	PROPN
ajlm-801	164	9	jz	jz	PROPN
ajlm-801	164	10	,	,	PUNCT
ajlm-801	164	11	et	et	PROPN
ajlm-801	164	12	al	al	PROPN
ajlm-801	164	13	.	.	PROPN
ajlm-801	164	14	high	high	ADJ
ajlm-801	164	15	-	-	PUNCT
ajlm-801	164	16	throughput	throughput	NOUN
ajlm-801	164	17	bacterial	bacterial	ADJ
ajlm-801	164	18	genome	genome	NOUN
ajlm-801	164	19	sequencing	sequencing	NOUN
ajlm-801	164	20	:	:	PUNCT
ajlm-801	164	21	an	an	DET
ajlm-801	164	22	embarrassment	embarrassment	NOUN
ajlm-801	164	23	of	of	ADP
ajlm-801	164	24	choice	choice	NOUN
ajlm-801	164	25	,	,	PUNCT
ajlm-801	164	26	a	a	DET
ajlm-801	164	27	world	world	NOUN
ajlm-801	164	28	of	of	ADP
ajlm-801	164	29	opportunity	opportunity	NOUN
ajlm-801	164	30	.	.	PUNCT
ajlm-801	165	1	nat	nat	PROPN
ajlm-801	165	2	rev	rev	PROPN
ajlm-801	165	3	microbiol	microbiol	PROPN
ajlm-801	165	4	.	.	PUNCT
ajlm-801	166	1	2012;10(9):599–606	2012;10(9):599–606	NUM
ajlm-801	166	2	.	.	PUNCT
ajlm-801	167	1	https://doi.org/10.1038/nrmicro2850	https://doi.org/10.1038/nrmicro2850	NOUN