id	sid	tid	token	lemma	pos
ajlm-988	1	1	abstract	abstract	ADJ
ajlm-988	1	2	introduction	introduction	NOUN
ajlm-988	1	3	methods	method	NOUN
ajlm-988	1	4	results	result	VERB
ajlm-988	1	5	discussion	discussion	NOUN
ajlm-988	1	6	acknowledgements	acknowledgement	NOUN
ajlm-988	1	7	references	reference	NOUN
ajlm-988	1	8	about	about	ADP
ajlm-988	1	9	the	the	DET
ajlm-988	1	10	author(s	author(s	NOUN
ajlm-988	1	11	)	)	PUNCT
ajlm-988	1	12	celeste	celeste	PROPN
ajlm-988	1	13	swart	swart	PROPN
ajlm-988	1	14	faculty	faculty	PROPN
ajlm-988	1	15	of	of	ADP
ajlm-988	1	16	health	health	NOUN
ajlm-988	1	17	sciences	sciences	PROPN
ajlm-988	1	18	,	,	PUNCT
ajlm-988	1	19	university	university	NOUN
ajlm-988	1	20	of	of	ADP
ajlm-988	1	21	cape	cape	PROPN
ajlm-988	1	22	town	town	NOUN
ajlm-988	1	23	,	,	PUNCT
ajlm-988	1	24	cape	cape	NOUN
ajlm-988	1	25	town	town	NOUN
ajlm-988	1	26	,	,	PUNCT
ajlm-988	1	27	south	south	PROPN
ajlm-988	1	28	africa	africa	PROPN
ajlm-988	1	29	national	national	PROPN
ajlm-988	1	30	health	health	PROPN
ajlm-988	1	31	laboratory	laboratory	PROPN
ajlm-988	1	32	service	service	NOUN
ajlm-988	1	33	(	(	PUNCT
ajlm-988	1	34	nhls	nhls	PROPN
ajlm-988	1	35	)	)	PUNCT
ajlm-988	1	36	,	,	PUNCT
ajlm-988	1	37	groote	groote	PROPN
ajlm-988	1	38	schuur	schuur	PROPN
ajlm-988	1	39	hospital	hospital	PROPN
ajlm-988	1	40	,	,	PUNCT
ajlm-988	1	41	cape	cape	NOUN
ajlm-988	1	42	town	town	NOUN
ajlm-988	1	43	,	,	PUNCT
ajlm-988	1	44	south	south	PROPN
ajlm-988	1	45	africa	africa	PROPN
ajlm-988	1	46	surita	surita	PROPN
ajlm-988	1	47	meldau	meldau	PROPN
ajlm-988	1	48	national	national	PROPN
ajlm-988	1	49	health	health	PROPN
ajlm-988	1	50	laboratory	laboratory	PROPN
ajlm-988	1	51	service	service	NOUN
ajlm-988	1	52	(	(	PUNCT
ajlm-988	1	53	nhls	nhls	PROPN
ajlm-988	1	54	)	)	PUNCT
ajlm-988	1	55	,	,	PUNCT
ajlm-988	1	56	groote	groote	PROPN
ajlm-988	1	57	schuur	schuur	PROPN
ajlm-988	1	58	hospital	hospital	PROPN
ajlm-988	1	59	,	,	PUNCT
ajlm-988	1	60	cape	cape	NOUN
ajlm-988	1	61	town	town	NOUN
ajlm-988	1	62	,	,	PUNCT
ajlm-988	1	63	south	south	PROPN
ajlm-988	1	64	africa	africa	PROPN
ajlm-988	1	65	division	division	NOUN
ajlm-988	1	66	of	of	ADP
ajlm-988	1	67	chemical	chemical	PROPN
ajlm-988	1	68	pathology	pathology	PROPN
ajlm-988	1	69	,	,	PUNCT
ajlm-988	1	70	university	university	PROPN
ajlm-988	1	71	of	of	ADP
ajlm-988	1	72	cape	cape	PROPN
ajlm-988	1	73	town	town	NOUN
ajlm-988	1	74	,	,	PUNCT
ajlm-988	1	75	cape	cape	NOUN
ajlm-988	1	76	town	town	NOUN
ajlm-988	1	77	,	,	PUNCT
ajlm-988	1	78	south	south	PROPN
ajlm-988	1	79	africa	africa	PROPN
ajlm-988	1	80	chad	chad	PROPN
ajlm-988	1	81	m.	m.	PROPN
ajlm-988	1	82	centner	centner	PROPN
ajlm-988	1	83	division	division	NOUN
ajlm-988	1	84	of	of	ADP
ajlm-988	1	85	medical	medical	ADJ
ajlm-988	1	86	microbiology	microbiology	NOUN
ajlm-988	1	87	,	,	PUNCT
ajlm-988	1	88	university	university	NOUN
ajlm-988	1	89	of	of	ADP
ajlm-988	1	90	cape	cape	PROPN
ajlm-988	1	91	town	town	NOUN
ajlm-988	1	92	,	,	PUNCT
ajlm-988	1	93	cape	cape	NOUN
ajlm-988	1	94	town	town	NOUN
ajlm-988	1	95	,	,	PUNCT
ajlm-988	1	96	south	south	PROPN
ajlm-988	1	97	africa	africa	PROPN
ajlm-988	1	98	national	national	PROPN
ajlm-988	1	99	health	health	PROPN
ajlm-988	1	100	laboratory	laboratory	PROPN
ajlm-988	1	101	service	service	NOUN
ajlm-988	1	102	(	(	PUNCT
ajlm-988	1	103	nhls	nhls	PROPN
ajlm-988	1	104	)	)	PUNCT
ajlm-988	1	105	,	,	PUNCT
ajlm-988	1	106	medical	medical	ADJ
ajlm-988	1	107	microbiology	microbiology	NOUN
ajlm-988	1	108	,	,	PUNCT
ajlm-988	1	109	groote	groote	PROPN
ajlm-988	1	110	schuur	schuur	PROPN
ajlm-988	1	111	hospital	hospital	PROPN
ajlm-988	1	112	,	,	PUNCT
ajlm-988	1	113	cape	cape	NOUN
ajlm-988	1	114	town	town	NOUN
ajlm-988	1	115	,	,	PUNCT
ajlm-988	1	116	south	south	PROPN
ajlm-988	1	117	africa	africa	PROPN
ajlm-988	1	118	adrian	adrian	PROPN
ajlm-988	1	119	d.	d.	PROPN
ajlm-988	1	120	marais	marais	PROPN
ajlm-988	1	121	division	division	PROPN
ajlm-988	1	122	of	of	ADP
ajlm-988	1	123	chemical	chemical	PROPN
ajlm-988	1	124	pathology	pathology	PROPN
ajlm-988	1	125	,	,	PUNCT
ajlm-988	1	126	university	university	PROPN
ajlm-988	1	127	of	of	ADP
ajlm-988	1	128	cape	cape	PROPN
ajlm-988	1	129	town	town	NOUN
ajlm-988	1	130	,	,	PUNCT
ajlm-988	1	131	cape	cape	NOUN
ajlm-988	1	132	town	town	NOUN
ajlm-988	1	133	,	,	PUNCT
ajlm-988	1	134	south	south	PROPN
ajlm-988	1	135	africa	africa	PROPN
ajlm-988	1	136	fierdoz	fierdoz	PROPN
ajlm-988	1	137	omar	omar	PROPN
ajlm-988	1	138	division	division	PROPN
ajlm-988	1	139	of	of	ADP
ajlm-988	1	140	chemical	chemical	PROPN
ajlm-988	1	141	pathology	pathology	PROPN
ajlm-988	1	142	,	,	PUNCT
ajlm-988	1	143	university	university	PROPN
ajlm-988	1	144	of	of	ADP
ajlm-988	1	145	cape	cape	PROPN
ajlm-988	1	146	town	town	NOUN
ajlm-988	1	147	,	,	PUNCT
ajlm-988	1	148	cape	cape	NOUN
ajlm-988	1	149	town	town	NOUN
ajlm-988	1	150	,	,	PUNCT
ajlm-988	1	151	south	south	PROPN
ajlm-988	1	152	africa	africa	PROPN
ajlm-988	1	153	citation	citation	PROPN
ajlm-988	1	154	swart	swart	PROPN
ajlm-988	1	155	c	c	PROPN
ajlm-988	1	156	,	,	PUNCT
ajlm-988	1	157	meldau	meldau	PROPN
ajlm-988	1	158	s	s	PART
ajlm-988	1	159	,	,	PUNCT
ajlm-988	1	160	centner	centner	NOUN
ajlm-988	1	161	cm	cm	PROPN
ajlm-988	1	162	,	,	PUNCT
ajlm-988	1	163	marais	marais	PROPN
ajlm-988	1	164	ad	ad	NOUN
ajlm-988	1	165	,	,	PUNCT
ajlm-988	1	166	omar	omar	PROPN
ajlm-988	1	167	f.	f.	PROPN
ajlm-988	1	168	validation	validation	PROPN
ajlm-988	1	169	of	of	ADP
ajlm-988	1	170	phase	phase	NOUN
ajlm-988	1	171	for	for	ADP
ajlm-988	1	172	deriving	derive	VERB
ajlm-988	1	173	n	n	CCONJ
ajlm-988	1	174	-	-	PUNCT
ajlm-988	1	175	acetyltransferase	acetyltransferase	ADJ
ajlm-988	1	176	2	2	NUM
ajlm-988	1	177	haplotypes	haplotype	NOUN
ajlm-988	1	178	in	in	ADP
ajlm-988	1	179	the	the	DET
ajlm-988	1	180	western	western	ADJ
ajlm-988	1	181	cape	cape	NOUN
ajlm-988	1	182	mixed	mixed	ADJ
ajlm-988	1	183	ancestry	ancestry	NOUN
ajlm-988	1	184	population	population	NOUN
ajlm-988	1	185	.	.	PUNCT
ajlm-988	2	1	afr	afr	PROPN
ajlm-988	2	2	j	j	PROPN
ajlm-988	2	3	lab	lab	PROPN
ajlm-988	2	4	med	me	VERB
ajlm-988	2	5	.	.	PUNCT
ajlm-988	2	6	2020;9(1	2020;9(1	NUM
ajlm-988	2	7	)	)	PUNCT
ajlm-988	2	8	,	,	PUNCT
ajlm-988	2	9	a988	a988	PROPN
ajlm-988	2	10	.	.	PROPN
ajlm-988	2	11	https://doi.org/10.4102/ajlm.v9i1.988	https://doi.org/10.4102/ajlm.v9i1.988	VERB
ajlm-988	2	12	original	original	ADJ
ajlm-988	2	13	research	research	NOUN
ajlm-988	2	14	validation	validation	NOUN
ajlm-988	2	15	of	of	ADP
ajlm-988	2	16	phase	phase	NOUN
ajlm-988	2	17	for	for	ADP
ajlm-988	2	18	deriving	derive	VERB
ajlm-988	2	19	n	n	CCONJ
ajlm-988	2	20	-	-	PUNCT
ajlm-988	2	21	acetyltransferase	acetyltransferase	ADJ
ajlm-988	2	22	2	2	NUM
ajlm-988	2	23	haplotypes	haplotype	NOUN
ajlm-988	2	24	in	in	ADP
ajlm-988	2	25	the	the	DET
ajlm-988	2	26	western	western	ADJ
ajlm-988	2	27	cape	cape	NOUN
ajlm-988	2	28	mixed	mixed	ADJ
ajlm-988	2	29	ancestry	ancestry	NOUN
ajlm-988	2	30	population	population	NOUN
ajlm-988	2	31	celeste	celeste	PROPN
ajlm-988	2	32	swart	swart	PROPN
ajlm-988	2	33	,	,	PUNCT
ajlm-988	2	34	surita	surita	PROPN
ajlm-988	2	35	meldau	meldau	NOUN
ajlm-988	2	36	,	,	PUNCT
ajlm-988	2	37	chad	chad	PROPN
ajlm-988	2	38	m.	m.	PROPN
ajlm-988	2	39	centner	centner	PROPN
ajlm-988	2	40	,	,	PUNCT
ajlm-988	2	41	adrian	adrian	PROPN
ajlm-988	2	42	d.	d.	PROPN
ajlm-988	2	43	marais	marais	PROPN
ajlm-988	2	44	,	,	PUNCT
ajlm-988	2	45	fierdoz	fierdoz	PROPN
ajlm-988	2	46	omar	omar	PROPN
ajlm-988	2	47	received	receive	VERB
ajlm-988	2	48	:	:	PUNCT
ajlm-988	2	49	28	28	NUM
ajlm-988	2	50	jan	jan	PROPN
ajlm-988	2	51	.	.	PROPN
ajlm-988	2	52	2019	2019	NUM
ajlm-988	2	53	;	;	PUNCT
ajlm-988	2	54	accepted	accept	VERB
ajlm-988	2	55	:	:	PUNCT
ajlm-988	2	56	14	14	NUM
ajlm-988	2	57	sept	sept	PROPN
ajlm-988	2	58	.	.	PROPN
ajlm-988	2	59	2020	2020	NUM
ajlm-988	2	60	;	;	PUNCT
ajlm-988	2	61	published	publish	VERB
ajlm-988	2	62	:	:	PUNCT
ajlm-988	2	63	17	17	NUM
ajlm-988	2	64	dec	dec	PROPN
ajlm-988	2	65	.	.	PROPN
ajlm-988	3	1	2020	2020	NUM
ajlm-988	3	2	copyright	copyright	NOUN
ajlm-988	3	3	:	:	PUNCT
ajlm-988	3	4	©	©	PROPN
ajlm-988	3	5	2020	2020	NUM
ajlm-988	3	6	.	.	PUNCT
ajlm-988	4	1	the	the	DET
ajlm-988	4	2	author(s	author(s	PROPN
ajlm-988	4	3	)	)	PUNCT
ajlm-988	4	4	.	.	PUNCT
ajlm-988	5	1	licensee	licensee	NOUN
ajlm-988	5	2	:	:	PUNCT
ajlm-988	5	3	aosis	aosis	NOUN
ajlm-988	5	4	.	.	PUNCT
ajlm-988	6	1	this	this	PRON
ajlm-988	6	2	is	be	AUX
ajlm-988	6	3	an	an	DET
ajlm-988	6	4	open	open	ADJ
ajlm-988	6	5	access	access	NOUN
ajlm-988	6	6	article	article	NOUN
ajlm-988	6	7	distributed	distribute	VERB
ajlm-988	6	8	under	under	ADP
ajlm-988	6	9	the	the	DET
ajlm-988	6	10	terms	term	NOUN
ajlm-988	6	11	of	of	ADP
ajlm-988	6	12	the	the	DET
ajlm-988	6	13	creative	creative	ADJ
ajlm-988	6	14	commons	common	NOUN
ajlm-988	6	15	attribution	attribution	NOUN
ajlm-988	6	16	license	license	NOUN
ajlm-988	6	17	,	,	PUNCT
ajlm-988	6	18	which	which	PRON
ajlm-988	6	19	permits	permit	VERB
ajlm-988	6	20	unrestricted	unrestricted	ADJ
ajlm-988	6	21	use	use	NOUN
ajlm-988	6	22	,	,	PUNCT
ajlm-988	6	23	distribution	distribution	NOUN
ajlm-988	6	24	,	,	PUNCT
ajlm-988	6	25	and	and	CCONJ
ajlm-988	6	26	reproduction	reproduction	NOUN
ajlm-988	6	27	in	in	ADP
ajlm-988	6	28	any	any	DET
ajlm-988	6	29	medium	medium	NOUN
ajlm-988	6	30	,	,	PUNCT
ajlm-988	6	31	provided	provide	VERB
ajlm-988	6	32	the	the	DET
ajlm-988	6	33	original	original	ADJ
ajlm-988	6	34	work	work	NOUN
ajlm-988	6	35	is	be	AUX
ajlm-988	6	36	properly	properly	ADV
ajlm-988	6	37	cited	cite	VERB
ajlm-988	6	38	.	.	PUNCT
ajlm-988	7	1	abstract	abstract	ADJ
ajlm-988	7	2	background	background	NOUN
ajlm-988	7	3	:	:	PUNCT
ajlm-988	7	4	there	there	PRON
ajlm-988	7	5	is	be	VERB
ajlm-988	7	6	a	a	DET
ajlm-988	7	7	shortage	shortage	NOUN
ajlm-988	7	8	of	of	ADP
ajlm-988	7	9	data	datum	NOUN
ajlm-988	7	10	on	on	ADP
ajlm-988	7	11	the	the	DET
ajlm-988	7	12	accuracy	accuracy	NOUN
ajlm-988	7	13	of	of	ADP
ajlm-988	7	14	statistical	statistical	ADJ
ajlm-988	7	15	methods	method	NOUN
ajlm-988	7	16	for	for	ADP
ajlm-988	7	17	the	the	DET
ajlm-988	7	18	prediction	prediction	NOUN
ajlm-988	7	19	of	of	ADP
ajlm-988	7	20	n	n	CCONJ
ajlm-988	7	21	-	-	PUNCT
ajlm-988	7	22	acetyltransferase	acetyltransferase	ADJ
ajlm-988	7	23	2	2	NUM
ajlm-988	7	24	(	(	PUNCT
ajlm-988	7	25	nat2	nat2	NOUN
ajlm-988	7	26	)	)	PUNCT
ajlm-988	7	27	haplotypes	haplotype	NOUN
ajlm-988	7	28	in	in	ADP
ajlm-988	7	29	the	the	DET
ajlm-988	7	30	mixed	mixed	ADJ
ajlm-988	7	31	ancestry	ancestry	NOUN
ajlm-988	7	32	population	population	NOUN
ajlm-988	7	33	of	of	ADP
ajlm-988	7	34	the	the	DET
ajlm-988	7	35	western	western	ADJ
ajlm-988	7	36	cape	cape	NOUN
ajlm-988	7	37	.	.	PUNCT
ajlm-988	8	1	objective	objective	NOUN
ajlm-988	8	2	:	:	PUNCT
ajlm-988	8	3	this	this	DET
ajlm-988	8	4	study	study	NOUN
ajlm-988	8	5	aimed	aim	VERB
ajlm-988	8	6	to	to	PART
ajlm-988	8	7	identify	identify	VERB
ajlm-988	8	8	the	the	DET
ajlm-988	8	9	nat2	nat2	NOUN
ajlm-988	8	10	haplotypes	haplotype	NOUN
ajlm-988	8	11	and	and	CCONJ
ajlm-988	8	12	assess	assess	VERB
ajlm-988	8	13	the	the	DET
ajlm-988	8	14	accuracy	accuracy	NOUN
ajlm-988	8	15	of	of	ADP
ajlm-988	8	16	phase	phase	NOUN
ajlm-988	8	17	version	version	NOUN
ajlm-988	8	18	2.1.1	2.1.1	NUM
ajlm-988	8	19	in	in	ADP
ajlm-988	8	20	assigning	assign	VERB
ajlm-988	8	21	nat2	nat2	NOUN
ajlm-988	8	22	haplotypes	haplotype	NOUN
ajlm-988	8	23	to	to	ADP
ajlm-988	8	24	a	a	DET
ajlm-988	8	25	mixed	mixed	ADJ
ajlm-988	8	26	ancestry	ancestry	NOUN
ajlm-988	8	27	population	population	NOUN
ajlm-988	8	28	from	from	ADP
ajlm-988	8	29	the	the	DET
ajlm-988	8	30	western	western	ADJ
ajlm-988	8	31	cape	cape	NOUN
ajlm-988	8	32	.	.	PUNCT
ajlm-988	9	1	methods	method	NOUN
ajlm-988	9	2	:	:	PUNCT
ajlm-988	9	3	this	this	DET
ajlm-988	9	4	study	study	NOUN
ajlm-988	9	5	was	be	AUX
ajlm-988	9	6	conducted	conduct	VERB
ajlm-988	9	7	between	between	ADP
ajlm-988	9	8	2013	2013	NUM
ajlm-988	9	9	and	and	CCONJ
ajlm-988	9	10	2016	2016	NUM
ajlm-988	9	11	.	.	PUNCT
ajlm-988	10	1	the	the	DET
ajlm-988	10	2	nat2	nat2	PROPN
ajlm-988	10	3	gene	gene	NOUN
ajlm-988	10	4	was	be	AUX
ajlm-988	10	5	amplified	amplify	VERB
ajlm-988	10	6	and	and	CCONJ
ajlm-988	10	7	sequenced	sequence	VERB
ajlm-988	10	8	from	from	ADP
ajlm-988	10	9	the	the	DET
ajlm-988	10	10	dna	dna	NOUN
ajlm-988	10	11	of	of	ADP
ajlm-988	10	12	100	100	NUM
ajlm-988	10	13	self	self	NOUN
ajlm-988	10	14	-	-	PUNCT
ajlm-988	10	15	identified	identify	VERB
ajlm-988	10	16	mixed	mixed	ADJ
ajlm-988	10	17	ancestry	ancestry	NOUN
ajlm-988	10	18	participants	participant	NOUN
ajlm-988	10	19	.	.	PUNCT
ajlm-988	11	1	haplotyping	haplotype	VERB
ajlm-988	11	2	was	be	AUX
ajlm-988	11	3	performed	perform	VERB
ajlm-988	11	4	by	by	ADP
ajlm-988	11	5	molecular	molecular	ADJ
ajlm-988	11	6	and	and	CCONJ
ajlm-988	11	7	computational	computational	ADJ
ajlm-988	11	8	techniques	technique	NOUN
ajlm-988	11	9	.	.	PUNCT
ajlm-988	12	1	agreement	agreement	NOUN
ajlm-988	12	2	was	be	AUX
ajlm-988	12	3	assessed	assess	VERB
ajlm-988	12	4	between	between	ADP
ajlm-988	12	5	the	the	DET
ajlm-988	12	6	two	two	NUM
ajlm-988	12	7	techniques	technique	NOUN
ajlm-988	12	8	.	.	PUNCT
ajlm-988	13	1	results	result	NOUN
ajlm-988	13	2	:	:	PUNCT
ajlm-988	13	3	haplotypes	haplotype	NOUN
ajlm-988	13	4	were	be	AUX
ajlm-988	13	5	assigned	assign	VERB
ajlm-988	13	6	to	to	ADP
ajlm-988	13	7	93	93	NUM
ajlm-988	13	8	samples	sample	NOUN
ajlm-988	13	9	,	,	PUNCT
ajlm-988	13	10	of	of	ADP
ajlm-988	13	11	which	which	PRON
ajlm-988	13	12	67	67	NUM
ajlm-988	13	13	(	(	PUNCT
ajlm-988	13	14	72	72	NUM
ajlm-988	13	15	%	%	NOUN
ajlm-988	13	16	)	)	PUNCT
ajlm-988	13	17	were	be	AUX
ajlm-988	13	18	ambiguous	ambiguous	ADJ
ajlm-988	13	19	.	.	PUNCT
ajlm-988	14	1	haplotype	haplotype	NOUN
ajlm-988	14	2	prediction	prediction	NOUN
ajlm-988	14	3	by	by	ADP
ajlm-988	14	4	phase	phase	NOUN
ajlm-988	14	5	demonstrated	demonstrate	VERB
ajlm-988	14	6	94.6	94.6	NUM
ajlm-988	14	7	%	%	NOUN
ajlm-988	14	8	agreement	agreement	NOUN
ajlm-988	14	9	(	(	PUNCT
ajlm-988	14	10	kappa	kappa	NOUN
ajlm-988	14	11	0.94	0.94	NUM
ajlm-988	14	12	,	,	PUNCT
ajlm-988	14	13	p	p	X
ajlm-988	14	14	<	<	X
ajlm-988	14	15	0.001	0.001	NUM
ajlm-988	14	16	)	)	PUNCT
ajlm-988	14	17	with	with	ADP
ajlm-988	14	18	those	those	PRON
ajlm-988	14	19	assigned	assign	VERB
ajlm-988	14	20	using	use	VERB
ajlm-988	14	21	molecular	molecular	ADJ
ajlm-988	14	22	techniques	technique	NOUN
ajlm-988	14	23	.	.	PUNCT
ajlm-988	15	1	five	five	NUM
ajlm-988	15	2	haplotype	haplotype	NOUN
ajlm-988	15	3	combinations	combination	NOUN
ajlm-988	15	4	(	(	PUNCT
ajlm-988	15	5	from	from	ADP
ajlm-988	15	6	10	10	NUM
ajlm-988	15	7	chromosomes	chromosome	NOUN
ajlm-988	15	8	)	)	PUNCT
ajlm-988	15	9	were	be	AUX
ajlm-988	15	10	incorrectly	incorrectly	ADV
ajlm-988	15	11	predicted	predict	VERB
ajlm-988	15	12	,	,	PUNCT
ajlm-988	15	13	four	four	NUM
ajlm-988	15	14	of	of	ADP
ajlm-988	15	15	which	which	PRON
ajlm-988	15	16	were	be	AUX
ajlm-988	15	17	flagged	flag	VERB
ajlm-988	15	18	as	as	ADV
ajlm-988	15	19	uncertain	uncertain	ADJ
ajlm-988	15	20	by	by	ADP
ajlm-988	15	21	the	the	DET
ajlm-988	15	22	phase	phase	NOUN
ajlm-988	15	23	software	software	NOUN
ajlm-988	15	24	.	.	PUNCT
ajlm-988	16	1	only	only	ADV
ajlm-988	16	2	one	one	NUM
ajlm-988	16	3	resulted	result	VERB
ajlm-988	16	4	in	in	ADP
ajlm-988	16	5	the	the	DET
ajlm-988	16	6	assignment	assignment	NOUN
ajlm-988	16	7	of	of	ADP
ajlm-988	16	8	an	an	DET
ajlm-988	16	9	incorrect	incorrect	ADJ
ajlm-988	16	10	acetylation	acetylation	NOUN
ajlm-988	16	11	phenotype	phenotype	NOUN
ajlm-988	16	12	(	(	PUNCT
ajlm-988	16	13	intermediate	intermediate	ADJ
ajlm-988	16	14	to	to	PART
ajlm-988	16	15	slow	slow	VERB
ajlm-988	16	16	)	)	PUNCT
ajlm-988	16	17	,	,	PUNCT
ajlm-988	16	18	although	although	SCONJ
ajlm-988	16	19	the	the	DET
ajlm-988	16	20	software	software	NOUN
ajlm-988	16	21	flagged	flag	VERB
ajlm-988	16	22	this	this	PRON
ajlm-988	16	23	for	for	ADP
ajlm-988	16	24	further	further	ADJ
ajlm-988	16	25	analysis	analysis	NOUN
ajlm-988	16	26	.	.	PUNCT
ajlm-988	17	1	the	the	DET
ajlm-988	17	2	most	most	ADV
ajlm-988	17	3	common	common	ADJ
ajlm-988	17	4	haplotypes	haplotype	NOUN
ajlm-988	17	5	were	be	AUX
ajlm-988	17	6	nat2	nat2	NOUN
ajlm-988	17	7	*	*	ADJ
ajlm-988	17	8	4	4	NUM
ajlm-988	17	9	(	(	PUNCT
ajlm-988	17	10	28	28	NUM
ajlm-988	17	11	%	%	NOUN
ajlm-988	17	12	)	)	PUNCT
ajlm-988	17	13	followed	follow	VERB
ajlm-988	17	14	by	by	ADP
ajlm-988	17	15	nat2	nat2	NOUN
ajlm-988	17	16	*	*	PUNCT
ajlm-988	17	17	5b	5b	NOUN
ajlm-988	17	18	(	(	PUNCT
ajlm-988	17	19	27.4	27.4	NUM
ajlm-988	17	20	%	%	NOUN
ajlm-988	17	21	)	)	PUNCT
ajlm-988	17	22	,	,	PUNCT
ajlm-988	17	23	nat2	nat2	PROPN
ajlm-988	17	24	*	*	NOUN
ajlm-988	17	25	6a	6a	NOUN
ajlm-988	17	26	(	(	PUNCT
ajlm-988	17	27	21.5	21.5	NUM
ajlm-988	17	28	%	%	NOUN
ajlm-988	17	29	)	)	PUNCT
ajlm-988	17	30	and	and	CCONJ
ajlm-988	17	31	nat2	nat2	PROPN
ajlm-988	17	32	*	*	NOUN
ajlm-988	17	33	12a	12a	NUM
ajlm-988	17	34	(	(	PUNCT
ajlm-988	17	35	7.5	7.5	NUM
ajlm-988	17	36	%	%	NOUN
ajlm-988	17	37	)	)	PUNCT
ajlm-988	17	38	.	.	PUNCT
ajlm-988	18	1	four	four	NUM
ajlm-988	18	2	rare	rare	ADJ
ajlm-988	18	3	single	single	ADJ
ajlm-988	18	4	nucleotide	nucleotide	NOUN
ajlm-988	18	5	variants	variant	NOUN
ajlm-988	18	6	(	(	PUNCT
ajlm-988	18	7	c.589c	c.589c	PROPN
ajlm-988	18	8	>	>	X
ajlm-988	18	9	t	t	PROPN
ajlm-988	18	10	,	,	PUNCT
ajlm-988	18	11	c.622t	c.622t	NOUN
ajlm-988	18	12	>	>	X
ajlm-988	18	13	c	c	X
ajlm-988	18	14	,	,	PUNCT
ajlm-988	18	15	c.809t	c.809t	PROPN
ajlm-988	18	16	>	>	X
ajlm-988	18	17	c	c	PROPN
ajlm-988	18	18	and	and	CCONJ
ajlm-988	18	19	c.387c	c.387c	PROPN
ajlm-988	18	20	>	>	PROPN
ajlm-988	18	21	t	t	PROPN
ajlm-988	18	22	)	)	PUNCT
ajlm-988	18	23	were	be	AUX
ajlm-988	18	24	detected	detect	VERB
ajlm-988	18	25	.	.	PUNCT
ajlm-988	19	1	conclusion	conclusion	NOUN
ajlm-988	19	2	:	:	PUNCT
ajlm-988	19	3	phase	phase	NOUN
ajlm-988	19	4	accurately	accurately	ADV
ajlm-988	19	5	predicted	predict	VERB
ajlm-988	19	6	the	the	DET
ajlm-988	19	7	phenotype	phenotype	NOUN
ajlm-988	19	8	in	in	ADP
ajlm-988	19	9	92	92	NUM
ajlm-988	19	10	of	of	ADP
ajlm-988	19	11	93	93	NUM
ajlm-988	19	12	samples	sample	NOUN
ajlm-988	19	13	(	(	PUNCT
ajlm-988	19	14	99	99	NUM
ajlm-988	19	15	%	%	NOUN
ajlm-988	19	16	)	)	PUNCT
ajlm-988	19	17	from	from	ADP
ajlm-988	19	18	genotypic	genotypic	ADJ
ajlm-988	19	19	data	datum	NOUN
ajlm-988	19	20	in	in	ADP
ajlm-988	19	21	our	our	PRON
ajlm-988	19	22	mixed	mixed	ADJ
ajlm-988	19	23	ancestry	ancestry	NOUN
ajlm-988	19	24	sample	sample	NOUN
ajlm-988	19	25	population	population	NOUN
ajlm-988	19	26	,	,	PUNCT
ajlm-988	19	27	and	and	CCONJ
ajlm-988	19	28	is	be	AUX
ajlm-988	19	29	therefore	therefore	ADV
ajlm-988	19	30	a	a	DET
ajlm-988	19	31	suitable	suitable	ADJ
ajlm-988	19	32	alternative	alternative	NOUN
ajlm-988	19	33	to	to	ADP
ajlm-988	19	34	molecular	molecular	ADJ
ajlm-988	19	35	methods	method	NOUN
ajlm-988	19	36	to	to	PART
ajlm-988	19	37	individualise	individualise	VERB
ajlm-988	19	38	isoniazid	isoniazid	NOUN
ajlm-988	19	39	therapy	therapy	NOUN
ajlm-988	19	40	in	in	ADP
ajlm-988	19	41	this	this	DET
ajlm-988	19	42	high	high	ADJ
ajlm-988	19	43	burden	burden	NOUN
ajlm-988	19	44	tuberculosis	tuberculosis	NOUN
ajlm-988	19	45	setting	setting	NOUN
ajlm-988	19	46	.	.	PUNCT
ajlm-988	20	1	keywords	keyword	NOUN
ajlm-988	20	2	:	:	PUNCT
ajlm-988	20	3	nat2	nat2	NOUN
ajlm-988	20	4	;	;	PUNCT
ajlm-988	20	5	haplotyping	haplotyping	NOUN
ajlm-988	20	6	;	;	PUNCT
ajlm-988	20	7	isoniazid	isoniazid	NOUN
ajlm-988	20	8	;	;	PUNCT
ajlm-988	20	9	pathology	pathology	NOUN
ajlm-988	20	10	;	;	PUNCT
ajlm-988	20	11	molecular	molecular	ADJ
ajlm-988	20	12	.	.	PUNCT
ajlm-988	21	1	introduction	introduction	NOUN
ajlm-988	21	2	tuberculosis	tuberculosis	NOUN
ajlm-988	21	3	remains	remain	VERB
ajlm-988	21	4	a	a	DET
ajlm-988	21	5	global	global	ADJ
ajlm-988	21	6	life	life	NOUN
ajlm-988	21	7	-	-	PUNCT
ajlm-988	21	8	threatening	threaten	VERB
ajlm-988	21	9	infectious	infectious	ADJ
ajlm-988	21	10	disease.1	disease.1	PROPN
ajlm-988	21	11	patients	patient	NOUN
ajlm-988	21	12	in	in	ADP
ajlm-988	21	13	developing	develop	VERB
ajlm-988	21	14	countries	country	NOUN
ajlm-988	21	15	are	be	AUX
ajlm-988	21	16	particularly	particularly	ADV
ajlm-988	21	17	vulnerable	vulnerable	ADJ
ajlm-988	21	18	,	,	PUNCT
ajlm-988	21	19	as	as	SCONJ
ajlm-988	21	20	informal	informal	ADJ
ajlm-988	21	21	settlements	settlement	NOUN
ajlm-988	21	22	and	and	CCONJ
ajlm-988	21	23	overcrowded	overcrowded	ADJ
ajlm-988	21	24	environments	environment	NOUN
ajlm-988	21	25	provide	provide	VERB
ajlm-988	21	26	optimal	optimal	ADJ
ajlm-988	21	27	conditions	condition	NOUN
ajlm-988	21	28	for	for	ADP
ajlm-988	21	29	the	the	DET
ajlm-988	21	30	spread	spread	NOUN
ajlm-988	21	31	of	of	ADP
ajlm-988	21	32	tuberculosis	tuberculosis	NOUN
ajlm-988	21	33	.	.	PUNCT
ajlm-988	22	1	according	accord	VERB
ajlm-988	22	2	to	to	ADP
ajlm-988	22	3	the	the	DET
ajlm-988	22	4	national	national	ADJ
ajlm-988	22	5	strategic	strategic	ADJ
ajlm-988	22	6	plan	plan	NOUN
ajlm-988	22	7	,	,	PUNCT
ajlm-988	22	8	south	south	PROPN
ajlm-988	22	9	africa	africa	PROPN
ajlm-988	22	10	has	have	VERB
ajlm-988	22	11	the	the	DET
ajlm-988	22	12	third	third	ADV
ajlm-988	22	13	highest	high	ADJ
ajlm-988	22	14	tuberculosis	tuberculosis	NOUN
ajlm-988	22	15	burden	burden	NOUN
ajlm-988	22	16	worldwide	worldwide	ADV
ajlm-988	22	17	.	.	PUNCT
ajlm-988	23	1	with	with	ADP
ajlm-988	23	2	an	an	DET
ajlm-988	23	3	annual	annual	ADJ
ajlm-988	23	4	incidence	incidence	NOUN
ajlm-988	23	5	of	of	ADP
ajlm-988	23	6	approximately	approximately	ADV
ajlm-988	23	7	1%.2	1%.2	NUM
ajlm-988	23	8	the	the	DET
ajlm-988	23	9	western	western	ADJ
ajlm-988	23	10	cape	cape	NOUN
ajlm-988	23	11	demonstrates	demonstrate	VERB
ajlm-988	23	12	nearly	nearly	ADV
ajlm-988	23	13	the	the	DET
ajlm-988	23	14	highest	high	ADJ
ajlm-988	23	15	global	global	ADJ
ajlm-988	23	16	incidence	incidence	NOUN
ajlm-988	23	17	of	of	ADP
ajlm-988	23	18	tuberculosis	tuberculosis	NOUN
ajlm-988	23	19	,	,	PUNCT
ajlm-988	23	20	with	with	ADP
ajlm-988	23	21	the	the	DET
ajlm-988	23	22	mixed	mixed	ADJ
ajlm-988	23	23	ancestry	ancestry	NOUN
ajlm-988	23	24	population	population	NOUN
ajlm-988	23	25	being	be	AUX
ajlm-988	23	26	particularly	particularly	ADV
ajlm-988	23	27	affected.3	affected.3	PRON
ajlm-988	23	28	isoniazid	isoniazid	NOUN
ajlm-988	23	29	is	be	AUX
ajlm-988	23	30	a	a	DET
ajlm-988	23	31	key	key	ADJ
ajlm-988	23	32	first	first	ADJ
ajlm-988	23	33	-	-	PUNCT
ajlm-988	23	34	line	line	NOUN
ajlm-988	23	35	antimicrobial	antimicrobial	ADJ
ajlm-988	23	36	drug	drug	NOUN
ajlm-988	23	37	in	in	ADP
ajlm-988	23	38	the	the	DET
ajlm-988	23	39	treatment	treatment	NOUN
ajlm-988	23	40	of	of	ADP
ajlm-988	23	41	tuberculosis	tuberculosis	NOUN
ajlm-988	23	42	.	.	PUNCT
ajlm-988	24	1	the	the	DET
ajlm-988	24	2	dosage	dosage	NOUN
ajlm-988	24	3	of	of	ADP
ajlm-988	24	4	isoniazid	isoniazid	NOUN
ajlm-988	24	5	is	be	AUX
ajlm-988	24	6	usually	usually	ADV
ajlm-988	24	7	standard	standard	ADJ
ajlm-988	24	8	and	and	CCONJ
ajlm-988	24	9	,	,	PUNCT
ajlm-988	24	10	in	in	ADP
ajlm-988	24	11	most	most	ADJ
ajlm-988	24	12	settings	setting	NOUN
ajlm-988	24	13	,	,	PUNCT
ajlm-988	24	14	related	relate	VERB
ajlm-988	24	15	to	to	ADP
ajlm-988	24	16	body	body	NOUN
ajlm-988	24	17	mass	mass	NOUN
ajlm-988	24	18	in	in	ADP
ajlm-988	24	19	accordance	accordance	NOUN
ajlm-988	24	20	with	with	ADP
ajlm-988	24	21	world	world	NOUN
ajlm-988	24	22	health	health	NOUN
ajlm-988	24	23	organization	organization	NOUN
ajlm-988	24	24	treatment	treatment	NOUN
ajlm-988	24	25	guidelines.4	guidelines.4	PROPN
ajlm-988	24	26	however	however	ADV
ajlm-988	24	27	,	,	PUNCT
ajlm-988	24	28	elimination	elimination	NOUN
ajlm-988	24	29	of	of	ADP
ajlm-988	24	30	,	,	PUNCT
ajlm-988	24	31	and	and	CCONJ
ajlm-988	24	32	thus	thus	ADV
ajlm-988	24	33	response	response	NOUN
ajlm-988	24	34	to	to	ADP
ajlm-988	24	35	,	,	PUNCT
ajlm-988	24	36	the	the	DET
ajlm-988	24	37	drug	drug	NOUN
ajlm-988	24	38	are	be	AUX
ajlm-988	24	39	affected	affect	VERB
ajlm-988	24	40	by	by	ADP
ajlm-988	24	41	the	the	DET
ajlm-988	24	42	patient	patient	NOUN
ajlm-988	24	43	-	-	PUNCT
ajlm-988	24	44	specific	specific	ADJ
ajlm-988	24	45	expression	expression	NOUN
ajlm-988	24	46	of	of	ADP
ajlm-988	24	47	metabolising	metabolise	VERB
ajlm-988	24	48	enzymes	enzyme	NOUN
ajlm-988	24	49	,	,	PUNCT
ajlm-988	24	50	in	in	ADP
ajlm-988	24	51	particular	particular	ADJ
ajlm-988	24	52	arylamine	arylamine	NOUN
ajlm-988	24	53	n	n	CCONJ
ajlm-988	24	54	-	-	PUNCT
ajlm-988	24	55	acetyltransferase	acetyltransferase	ADJ
ajlm-988	24	56	2	2	NUM
ajlm-988	24	57	(	(	PUNCT
ajlm-988	24	58	nat2	nat2	PROPN
ajlm-988	24	59	)	)	PUNCT
ajlm-988	24	60	,	,	PUNCT
ajlm-988	24	61	which	which	PRON
ajlm-988	24	62	catalyses	catalyse	VERB
ajlm-988	24	63	n	n	CCONJ
ajlm-988	24	64	-	-	PUNCT
ajlm-988	24	65	acetylation	acetylation	NOUN
ajlm-988	24	66	of	of	ADP
ajlm-988	24	67	aryl	aryl	NOUN
ajlm-988	24	68	amines	amine	NOUN
ajlm-988	24	69	and	and	CCONJ
ajlm-988	24	70	aryl	aryl	NOUN
ajlm-988	24	71	hydrazines.5	hydrazines.5	ADV
ajlm-988	24	72	these	these	DET
ajlm-988	24	73	drugs	drug	NOUN
ajlm-988	24	74	include	include	VERB
ajlm-988	24	75	clinically	clinically	ADV
ajlm-988	24	76	important	important	ADJ
ajlm-988	24	77	antimicrobial	antimicrobial	ADJ
ajlm-988	24	78	agents	agent	NOUN
ajlm-988	24	79	such	such	ADJ
ajlm-988	24	80	as	as	ADP
ajlm-988	24	81	isoniazid	isoniazid	NOUN
ajlm-988	24	82	and	and	CCONJ
ajlm-988	24	83	sulphonamides	sulphonamide	NOUN
ajlm-988	24	84	,	,	PUNCT
ajlm-988	24	85	caffeine	caffeine	NOUN
ajlm-988	24	86	,	,	PUNCT
ajlm-988	24	87	dapsone	dapsone	PROPN
ajlm-988	24	88	as	as	ADV
ajlm-988	24	89	well	well	ADV
ajlm-988	24	90	as	as	ADP
ajlm-988	24	91	some	some	DET
ajlm-988	24	92	toxigenic	toxigenic	ADJ
ajlm-988	24	93	substances	substance	NOUN
ajlm-988	24	94	and	and	CCONJ
ajlm-988	24	95	carcinogenic	carcinogenic	ADJ
ajlm-988	24	96	chemicals	chemical	NOUN
ajlm-988	24	97	derived	derive	VERB
ajlm-988	24	98	from	from	ADP
ajlm-988	24	99	the	the	DET
ajlm-988	24	100	environment	environment	NOUN
ajlm-988	24	101	and	and	CCONJ
ajlm-988	24	102	human	human	ADJ
ajlm-988	24	103	diet	diet	NOUN
ajlm-988	24	104	.	.	PUNCT
ajlm-988	25	1	expression	expression	NOUN
ajlm-988	25	2	of	of	ADP
ajlm-988	25	3	nat2	nat2	PROPN
ajlm-988	25	4	is	be	AUX
ajlm-988	25	5	limited	limit	VERB
ajlm-988	25	6	to	to	ADP
ajlm-988	25	7	the	the	DET
ajlm-988	25	8	intestine	intestine	NOUN
ajlm-988	25	9	and	and	CCONJ
ajlm-988	25	10	liver.5	liver.5	VERB
ajlm-988	25	11	the	the	DET
ajlm-988	25	12	nat2	nat2	NOUN
ajlm-988	25	13	gene	gene	NOUN
ajlm-988	25	14	is	be	AUX
ajlm-988	25	15	located	locate	VERB
ajlm-988	25	16	on	on	ADP
ajlm-988	25	17	chromosome	chromosome	NOUN
ajlm-988	25	18	8p22	8p22	NOUN
ajlm-988	25	19	and	and	CCONJ
ajlm-988	25	20	has	have	VERB
ajlm-988	25	21	two	two	NUM
ajlm-988	25	22	exons,6,7,8	exons,6,7,8	NUM
ajlm-988	25	23	one	one	NUM
ajlm-988	25	24	of	of	ADP
ajlm-988	25	25	which	which	PRON
ajlm-988	25	26	is	be	AUX
ajlm-988	25	27	transcribed.9	transcribed.9	PROPN
ajlm-988	25	28	since	since	SCONJ
ajlm-988	25	29	the	the	DET
ajlm-988	25	30	discovery	discovery	NOUN
ajlm-988	25	31	of	of	ADP
ajlm-988	25	32	nat2	nat2	NOUN
ajlm-988	25	33	in	in	ADP
ajlm-988	25	34	1990,10	1990,10	NUM
ajlm-988	25	35	extensive	extensive	ADJ
ajlm-988	25	36	studies	study	NOUN
ajlm-988	25	37	in	in	ADP
ajlm-988	25	38	various	various	ADJ
ajlm-988	25	39	population	population	NOUN
ajlm-988	25	40	groups	group	NOUN
ajlm-988	25	41	have	have	AUX
ajlm-988	25	42	linked	link	VERB
ajlm-988	25	43	nat2	nat2	PROPN
ajlm-988	25	44	genetic	genetic	ADJ
ajlm-988	25	45	variants	variant	NOUN
ajlm-988	25	46	to	to	ADP
ajlm-988	25	47	enzyme	enzyme	NOUN
ajlm-988	25	48	function	function	NOUN
ajlm-988	25	49	,	,	PUNCT
ajlm-988	25	50	classifying	classify	VERB
ajlm-988	25	51	individuals	individual	NOUN
ajlm-988	25	52	as	as	ADP
ajlm-988	25	53	either	either	CCONJ
ajlm-988	25	54	slow	slow	ADJ
ajlm-988	25	55	,	,	PUNCT
ajlm-988	25	56	intermediate	intermediate	ADJ
ajlm-988	25	57	or	or	CCONJ
ajlm-988	25	58	fast	fast	ADJ
ajlm-988	25	59	acetylators	acetylator	NOUN
ajlm-988	25	60	.	.	PUNCT
ajlm-988	26	1	the	the	DET
ajlm-988	26	2	different	different	ADJ
ajlm-988	26	3	acetylator	acetylator	NOUN
ajlm-988	26	4	phenotypes	phenotype	NOUN
ajlm-988	26	5	determine	determine	VERB
ajlm-988	26	6	individual	individual	ADJ
ajlm-988	26	7	responses	response	NOUN
ajlm-988	26	8	to	to	ADP
ajlm-988	26	9	toxins	toxin	NOUN
ajlm-988	26	10	and	and	CCONJ
ajlm-988	26	11	prescribed	prescribed	ADJ
ajlm-988	26	12	medications	medication	NOUN
ajlm-988	26	13	,	,	PUNCT
ajlm-988	26	14	and	and	CCONJ
ajlm-988	26	15	also	also	ADV
ajlm-988	26	16	influence	influence	NOUN
ajlm-988	26	17	cancer	cancer	NOUN
ajlm-988	26	18	susceptibility.11	susceptibility.11	VERB
ajlm-988	26	19	the	the	DET
ajlm-988	26	20	acetylation	acetylation	NOUN
ajlm-988	26	21	phenotype	phenotype	NOUN
ajlm-988	26	22	can	can	AUX
ajlm-988	26	23	affect	affect	VERB
ajlm-988	26	24	clinical	clinical	ADJ
ajlm-988	26	25	outcome	outcome	NOUN
ajlm-988	26	26	on	on	ADP
ajlm-988	26	27	standard	standard	ADJ
ajlm-988	26	28	drug	drug	NOUN
ajlm-988	26	29	doses	dose	NOUN
ajlm-988	26	30	and	and	CCONJ
ajlm-988	26	31	may	may	AUX
ajlm-988	26	32	result	result	VERB
ajlm-988	26	33	in	in	ADP
ajlm-988	26	34	an	an	DET
ajlm-988	26	35	increased	increase	VERB
ajlm-988	26	36	risk	risk	NOUN
ajlm-988	26	37	of	of	ADP
ajlm-988	26	38	therapeutic	therapeutic	ADJ
ajlm-988	26	39	failure	failure	NOUN
ajlm-988	26	40	or	or	CCONJ
ajlm-988	26	41	adverse	adverse	ADJ
ajlm-988	26	42	drug	drug	NOUN
ajlm-988	26	43	reactions.12	reactions.12	VERB
ajlm-988	26	44	both	both	CCONJ
ajlm-988	26	45	lack	lack	NOUN
ajlm-988	26	46	and	and	CCONJ
ajlm-988	26	47	excess	excess	NOUN
ajlm-988	26	48	of	of	ADP
ajlm-988	26	49	nat2	nat2	NOUN
ajlm-988	26	50	(	(	PUNCT
ajlm-988	26	51	slow	slow	ADJ
ajlm-988	26	52	and	and	CCONJ
ajlm-988	26	53	fast	fast	ADJ
ajlm-988	26	54	acetylation	acetylation	NOUN
ajlm-988	26	55	)	)	PUNCT
ajlm-988	26	56	can	can	AUX
ajlm-988	26	57	be	be	AUX
ajlm-988	26	58	associated	associate	VERB
ajlm-988	26	59	with	with	ADP
ajlm-988	26	60	isoniazid	isoniazid	NOUN
ajlm-988	26	61	hepatotoxicity	hepatotoxicity	NOUN
ajlm-988	26	62	.	.	PUNCT
ajlm-988	27	1	the	the	DET
ajlm-988	27	2	major	major	ADJ
ajlm-988	27	3	metabolites	metabolite	NOUN
ajlm-988	27	4	associated	associate	VERB
ajlm-988	27	5	with	with	ADP
ajlm-988	27	6	isoniazid	isoniazid	NOUN
ajlm-988	27	7	metabolism	metabolism	NOUN
ajlm-988	27	8	are	be	AUX
ajlm-988	27	9	thought	think	VERB
ajlm-988	27	10	to	to	PART
ajlm-988	27	11	be	be	AUX
ajlm-988	27	12	responsible	responsible	ADJ
ajlm-988	27	13	for	for	ADP
ajlm-988	27	14	isoniazid	isoniazid	NOUN
ajlm-988	27	15	-	-	PUNCT
ajlm-988	27	16	induced	induce	VERB
ajlm-988	27	17	liver	liver	NOUN
ajlm-988	27	18	injury	injury	NOUN
ajlm-988	27	19	,	,	PUNCT
ajlm-988	27	20	while	while	SCONJ
ajlm-988	27	21	isoniazid	isoniazid	NOUN
ajlm-988	27	22	itself	itself	PRON
ajlm-988	27	23	can	can	AUX
ajlm-988	27	24	also	also	ADV
ajlm-988	27	25	cause	cause	VERB
ajlm-988	27	26	immune	immune	NOUN
ajlm-988	27	27	-	-	PUNCT
ajlm-988	27	28	mediated	mediate	VERB
ajlm-988	27	29	hepatotoxicity	hepatotoxicity	NOUN
ajlm-988	27	30	by	by	ADP
ajlm-988	27	31	binding	bind	VERB
ajlm-988	27	32	to	to	ADP
ajlm-988	27	33	liver	liver	NOUN
ajlm-988	27	34	proteins	protein	NOUN
ajlm-988	27	35	and	and	CCONJ
ajlm-988	27	36	serving	serve	VERB
ajlm-988	27	37	as	as	ADP
ajlm-988	27	38	a	a	DET
ajlm-988	27	39	hapten.13	hapten.13	NOUN
ajlm-988	27	40	it	it	PRON
ajlm-988	27	41	is	be	AUX
ajlm-988	27	42	thus	thus	ADV
ajlm-988	27	43	postulated	postulate	VERB
ajlm-988	27	44	that	that	SCONJ
ajlm-988	27	45	fast	fast	ADJ
ajlm-988	27	46	acetylators	acetylator	NOUN
ajlm-988	27	47	may	may	AUX
ajlm-988	27	48	have	have	VERB
ajlm-988	27	49	a	a	DET
ajlm-988	27	50	poor	poor	ADJ
ajlm-988	27	51	response	response	NOUN
ajlm-988	27	52	to	to	ADP
ajlm-988	27	53	treatment	treatment	NOUN
ajlm-988	27	54	as	as	ADP
ajlm-988	27	55	a	a	DET
ajlm-988	27	56	result	result	NOUN
ajlm-988	27	57	of	of	ADP
ajlm-988	27	58	suboptimal	suboptimal	ADJ
ajlm-988	27	59	exposure	exposure	NOUN
ajlm-988	27	60	to	to	ADP
ajlm-988	27	61	isoniazid	isoniazid	NOUN
ajlm-988	27	62	due	due	ADP
ajlm-988	27	63	to	to	ADP
ajlm-988	27	64	reduced	reduce	VERB
ajlm-988	27	65	isoniazid	isoniazid	NOUN
ajlm-988	27	66	plasma	plasma	NOUN
ajlm-988	27	67	levels	level	NOUN
ajlm-988	27	68	,	,	PUNCT
ajlm-988	27	69	as	as	ADV
ajlm-988	27	70	well	well	ADV
ajlm-988	27	71	as	as	ADP
ajlm-988	27	72	liver	liver	NOUN
ajlm-988	27	73	injury	injury	NOUN
ajlm-988	27	74	due	due	ADP
ajlm-988	27	75	to	to	ADP
ajlm-988	27	76	an	an	DET
ajlm-988	27	77	increased	increase	VERB
ajlm-988	27	78	rate	rate	NOUN
ajlm-988	27	79	of	of	ADP
ajlm-988	27	80	isoniazid	isoniazid	NOUN
ajlm-988	27	81	metabolite	metabolite	NOUN
ajlm-988	27	82	formation.13	formation.13	VERB
ajlm-988	27	83	conversely	conversely	ADV
ajlm-988	27	84	,	,	PUNCT
ajlm-988	27	85	slow	slow	ADJ
ajlm-988	27	86	acetylators	acetylator	NOUN
ajlm-988	27	87	achieve	achieve	VERB
ajlm-988	27	88	higher	high	ADJ
ajlm-988	27	89	isoniazid	isoniazid	NOUN
ajlm-988	27	90	plasma	plasma	NOUN
ajlm-988	27	91	levels	level	NOUN
ajlm-988	27	92	,	,	PUNCT
ajlm-988	27	93	since	since	SCONJ
ajlm-988	27	94	they	they	PRON
ajlm-988	27	95	can	can	AUX
ajlm-988	27	96	not	not	PART
ajlm-988	27	97	efficiently	efficiently	ADV
ajlm-988	27	98	metabolise	metabolise	VERB
ajlm-988	27	99	the	the	DET
ajlm-988	27	100	drug	drug	NOUN
ajlm-988	27	101	,	,	PUNCT
ajlm-988	27	102	leading	lead	VERB
ajlm-988	27	103	to	to	ADP
ajlm-988	27	104	hepatic	hepatic	ADJ
ajlm-988	27	105	injury.13	injury.13	PRON
ajlm-988	27	106	distinct	distinct	ADJ
ajlm-988	27	107	nat2	nat2	NOUN
ajlm-988	27	108	haplotypes	haplotype	NOUN
ajlm-988	27	109	have	have	AUX
ajlm-988	27	110	been	be	AUX
ajlm-988	27	111	described	describe	VERB
ajlm-988	27	112	,	,	PUNCT
ajlm-988	27	113	consisting	consist	VERB
ajlm-988	27	114	of	of	ADP
ajlm-988	27	115	up	up	ADP
ajlm-988	27	116	to	to	PART
ajlm-988	27	117	four	four	NUM
ajlm-988	27	118	single	single	ADJ
ajlm-988	27	119	nucleotide	nucleotide	NOUN
ajlm-988	27	120	variants	variant	NOUN
ajlm-988	27	121	(	(	PUNCT
ajlm-988	27	122	snvs	snvs	NOUN
ajlm-988	27	123	)	)	PUNCT
ajlm-988	27	124	in	in	ADP
ajlm-988	27	125	various	various	ADJ
ajlm-988	27	126	combinations	combination	NOUN
ajlm-988	27	127	.	.	PUNCT
ajlm-988	28	1	over	over	ADP
ajlm-988	28	2	100	100	NUM
ajlm-988	28	3	haplotypes	haplotype	NOUN
ajlm-988	28	4	have	have	AUX
ajlm-988	28	5	been	be	AUX
ajlm-988	28	6	classified	classify	VERB
ajlm-988	28	7	into	into	ADP
ajlm-988	28	8	20	20	NUM
ajlm-988	28	9	groups	group	NOUN
ajlm-988	28	10	according	accord	VERB
ajlm-988	28	11	to	to	ADP
ajlm-988	28	12	defining	define	VERB
ajlm-988	28	13	mutations	mutation	NOUN
ajlm-988	28	14	,	,	PUNCT
ajlm-988	28	15	for	for	ADP
ajlm-988	28	16	example	example	NOUN
ajlm-988	28	17	,	,	PUNCT
ajlm-988	28	18	the	the	DET
ajlm-988	28	19	nat2	nat2	PROPN
ajlm-988	28	20	*	*	SYM
ajlm-988	28	21	5	5	NUM
ajlm-988	28	22	group	group	NOUN
ajlm-988	28	23	includes	include	VERB
ajlm-988	28	24	29	29	NUM
ajlm-988	28	25	different	different	ADJ
ajlm-988	28	26	haplotypes	haplotype	NOUN
ajlm-988	28	27	and	and	CCONJ
ajlm-988	28	28	is	be	AUX
ajlm-988	28	29	defined	define	VERB
ajlm-988	28	30	by	by	ADP
ajlm-988	28	31	the	the	DET
ajlm-988	28	32	c.341t	c.341t	PROPN
ajlm-988	28	33	>	>	PROPN
ajlm-988	28	34	c	c	PROPN
ajlm-988	28	35	snvs	snvs	NOUN
ajlm-988	28	36	.	.	PUNCT
ajlm-988	29	1	each	each	DET
ajlm-988	29	2	haplotype	haplotype	NOUN
ajlm-988	29	3	is	be	AUX
ajlm-988	29	4	associated	associate	VERB
ajlm-988	29	5	with	with	ADP
ajlm-988	29	6	an	an	DET
ajlm-988	29	7	acetylation	acetylation	NOUN
ajlm-988	29	8	phenotype	phenotype	NOUN
ajlm-988	29	9	.	.	PUNCT
ajlm-988	30	1	in	in	ADP
ajlm-988	30	2	human	human	ADJ
ajlm-988	30	3	populations	population	NOUN
ajlm-988	30	4	globally	globally	ADV
ajlm-988	30	5	,	,	PUNCT
ajlm-988	30	6	the	the	DET
ajlm-988	30	7	seven	seven	NUM
ajlm-988	30	8	most	most	ADV
ajlm-988	30	9	prevalent	prevalent	ADJ
ajlm-988	30	10	nat2	nat2	NOUN
ajlm-988	30	11	haplotypes	haplotype	NOUN
ajlm-988	30	12	are	be	AUX
ajlm-988	30	13	:	:	PUNCT
ajlm-988	30	14	nat2	nat2	NOUN
ajlm-988	30	15	*	*	PUNCT
ajlm-988	30	16	4	4	NUM
ajlm-988	30	17	,	,	PUNCT
ajlm-988	30	18	nat2	nat2	NOUN
ajlm-988	30	19	*	*	PUNCT
ajlm-988	30	20	5b	5b	NUM
ajlm-988	30	21	,	,	PUNCT
ajlm-988	30	22	nat2	nat2	NOUN
ajlm-988	30	23	*	*	PUNCT
ajlm-988	30	24	6a	6a	NOUN
ajlm-988	30	25	,	,	PUNCT
ajlm-988	30	26	nat2	nat2	PROPN
ajlm-988	30	27	*	*	PUNCT
ajlm-988	30	28	7b	7b	PROPN
ajlm-988	30	29	,	,	PUNCT
ajlm-988	30	30	nat2	nat2	PROPN
ajlm-988	30	31	*	*	PUNCT
ajlm-988	30	32	12a	12a	NUM
ajlm-988	30	33	,	,	PUNCT
ajlm-988	30	34	nat2	nat2	PROPN
ajlm-988	30	35	*	*	SYM
ajlm-988	30	36	13a	13a	PROPN
ajlm-988	30	37	and	and	CCONJ
ajlm-988	30	38	nat2	nat2	PROPN
ajlm-988	30	39	*	*	NUM
ajlm-988	30	40	14.14	14.14	NUM
ajlm-988	30	41	these	these	DET
ajlm-988	30	42	haplotypes	haplotype	NOUN
ajlm-988	30	43	include	include	VERB
ajlm-988	30	44	various	various	ADJ
ajlm-988	30	45	combinations	combination	NOUN
ajlm-988	30	46	of	of	ADP
ajlm-988	30	47	nat2	nat2	PROPN
ajlm-988	30	48	snvs.15	snvs.15	PROPN
ajlm-988	30	49	nat2	nat2	PROPN
ajlm-988	30	50	*	*	SYM
ajlm-988	30	51	4	4	NUM
ajlm-988	30	52	is	be	AUX
ajlm-988	30	53	classified	classify	VERB
ajlm-988	30	54	as	as	ADP
ajlm-988	30	55	the	the	DET
ajlm-988	30	56	wild	wild	ADJ
ajlm-988	30	57	type	type	NOUN
ajlm-988	30	58	and	and	CCONJ
ajlm-988	30	59	is	be	AUX
ajlm-988	30	60	associated	associate	VERB
ajlm-988	30	61	with	with	ADP
ajlm-988	30	62	fast	fast	ADJ
ajlm-988	30	63	(	(	PUNCT
ajlm-988	30	64	normal	normal	ADJ
ajlm-988	30	65	)	)	PUNCT
ajlm-988	30	66	acetylator	acetylator	NOUN
ajlm-988	30	67	status	status	PROPN
ajlm-988	30	68	,	,	PUNCT
ajlm-988	30	69	as	as	SCONJ
ajlm-988	30	70	are	be	AUX
ajlm-988	30	71	the	the	DET
ajlm-988	30	72	nat2	nat2	NOUN
ajlm-988	30	73	*	*	SYM
ajlm-988	30	74	12a	12a	NOUN
ajlm-988	30	75	(	(	PUNCT
ajlm-988	30	76	c.803a	c.803a	NOUN
ajlm-988	30	77	>	>	NOUN
ajlm-988	30	78	g	g	NOUN
ajlm-988	30	79	)	)	PUNCT
ajlm-988	30	80	and	and	CCONJ
ajlm-988	30	81	nat2	nat2	PROPN
ajlm-988	30	82	*	*	NOUN
ajlm-988	30	83	13a	13a	PROPN
ajlm-988	30	84	(	(	PUNCT
ajlm-988	30	85	c.282c	c.282c	PROPN
ajlm-988	30	86	>	>	SYM
ajlm-988	30	87	t	t	PROPN
ajlm-988	30	88	)	)	PUNCT
ajlm-988	30	89	haplotypes	haplotype	NOUN
ajlm-988	30	90	.	.	PUNCT
ajlm-988	31	1	the	the	DET
ajlm-988	31	2	other	other	ADJ
ajlm-988	31	3	four	four	NUM
ajlm-988	31	4	common	common	ADJ
ajlm-988	31	5	haplotypes	haplotype	NOUN
ajlm-988	31	6	are	be	AUX
ajlm-988	31	7	associated	associate	VERB
ajlm-988	31	8	with	with	ADP
ajlm-988	31	9	either	either	CCONJ
ajlm-988	31	10	significantly	significantly	ADV
ajlm-988	31	11	decreased	decrease	VERB
ajlm-988	31	12	expression	expression	NOUN
ajlm-988	31	13	or	or	CCONJ
ajlm-988	31	14	decreased	decrease	VERB
ajlm-988	31	15	stability	stability	NOUN
ajlm-988	31	16	of	of	ADP
ajlm-988	31	17	the	the	DET
ajlm-988	31	18	nat2	nat2	PROPN
ajlm-988	31	19	enzyme.16	enzyme.16	PROPN
ajlm-988	31	20	heterozygotes	heterozygote	VERB
ajlm-988	31	21	for	for	ADP
ajlm-988	31	22	fast	fast	ADJ
ajlm-988	31	23	and	and	CCONJ
ajlm-988	31	24	slow	slow	ADJ
ajlm-988	31	25	alleles	allele	NOUN
ajlm-988	31	26	demonstrate	demonstrate	VERB
ajlm-988	31	27	intermediate	intermediate	ADJ
ajlm-988	31	28	acetylating	acetylate	VERB
ajlm-988	31	29	activity	activity	NOUN
ajlm-988	31	30	.	.	PUNCT
ajlm-988	32	1	genotyping	genotyping	NOUN
ajlm-988	32	2	is	be	AUX
ajlm-988	32	3	typically	typically	ADV
ajlm-988	32	4	performed	perform	VERB
ajlm-988	32	5	using	use	VERB
ajlm-988	32	6	conventional	conventional	ADJ
ajlm-988	32	7	restriction	restriction	NOUN
ajlm-988	32	8	fragment	fragment	NOUN
ajlm-988	32	9	length	length	NOUN
ajlm-988	32	10	polymorphism	polymorphism	NOUN
ajlm-988	32	11	(	(	PUNCT
ajlm-988	32	12	rflp	rflp	PROPN
ajlm-988	32	13	)	)	PUNCT
ajlm-988	32	14	analysis	analysis	NOUN
ajlm-988	32	15	to	to	PART
ajlm-988	32	16	detect	detect	VERB
ajlm-988	32	17	the	the	DET
ajlm-988	32	18	most	most	ADV
ajlm-988	32	19	common	common	ADJ
ajlm-988	32	20	variants	variant	NOUN
ajlm-988	32	21	only	only	ADV
ajlm-988	32	22	,	,	PUNCT
ajlm-988	32	23	or	or	CCONJ
ajlm-988	32	24	sanger	sanger	PROPN
ajlm-988	32	25	sequencing	sequence	VERB
ajlm-988	32	26	to	to	PART
ajlm-988	32	27	detect	detect	VERB
ajlm-988	32	28	all	all	DET
ajlm-988	32	29	snvs	snvs	NOUN
ajlm-988	32	30	in	in	ADP
ajlm-988	32	31	the	the	DET
ajlm-988	32	32	nat2	nat2	NOUN
ajlm-988	32	33	region	region	NOUN
ajlm-988	32	34	.	.	PUNCT
ajlm-988	33	1	ambiguous	ambiguous	ADJ
ajlm-988	33	2	nat2	nat2	NOUN
ajlm-988	33	3	genotyping	genotyping	NOUN
ajlm-988	33	4	results	result	NOUN
ajlm-988	33	5	(	(	PUNCT
ajlm-988	33	6	the	the	DET
ajlm-988	33	7	presence	presence	NOUN
ajlm-988	33	8	of	of	ADP
ajlm-988	33	9	more	more	ADJ
ajlm-988	33	10	than	than	ADP
ajlm-988	33	11	one	one	NUM
ajlm-988	33	12	heterozygous	heterozygous	ADJ
ajlm-988	33	13	snv	snv	NOUN
ajlm-988	33	14	in	in	ADP
ajlm-988	33	15	the	the	DET
ajlm-988	33	16	same	same	ADJ
ajlm-988	33	17	patient	patient	NOUN
ajlm-988	33	18	)	)	PUNCT
ajlm-988	33	19	commonly	commonly	ADV
ajlm-988	33	20	arise	arise	VERB
ajlm-988	33	21	from	from	ADP
ajlm-988	33	22	sequencing	sequence	VERB
ajlm-988	33	23	data	datum	NOUN
ajlm-988	33	24	due	due	ADP
ajlm-988	33	25	to	to	ADP
ajlm-988	33	26	simultaneous	simultaneous	ADJ
ajlm-988	33	27	analysis	analysis	NOUN
ajlm-988	33	28	of	of	ADP
ajlm-988	33	29	both	both	CCONJ
ajlm-988	33	30	maternal	maternal	ADJ
ajlm-988	33	31	and	and	CCONJ
ajlm-988	33	32	paternal	paternal	ADJ
ajlm-988	33	33	alleles	allele	NOUN
ajlm-988	33	34	.	.	PUNCT
ajlm-988	34	1	this	this	PRON
ajlm-988	34	2	can	can	AUX
ajlm-988	34	3	cause	cause	VERB
ajlm-988	34	4	uncertainty	uncertainty	NOUN
ajlm-988	34	5	predicting	predict	VERB
ajlm-988	34	6	the	the	DET
ajlm-988	34	7	nat2	nat2	NOUN
ajlm-988	34	8	phenotype	phenotype	NOUN
ajlm-988	34	9	as	as	SCONJ
ajlm-988	34	10	it	it	PRON
ajlm-988	34	11	may	may	AUX
ajlm-988	34	12	be	be	AUX
ajlm-988	34	13	unclear	unclear	ADJ
ajlm-988	34	14	if	if	SCONJ
ajlm-988	34	15	one	one	NUM
ajlm-988	34	16	or	or	CCONJ
ajlm-988	34	17	both	both	PRON
ajlm-988	34	18	alleles	allele	NOUN
ajlm-988	34	19	carry	carry	VERB
ajlm-988	34	20	variants	variant	NOUN
ajlm-988	34	21	with	with	ADP
ajlm-988	34	22	functional	functional	ADJ
ajlm-988	34	23	effects	effect	NOUN
ajlm-988	34	24	.	.	PUNCT
ajlm-988	35	1	in	in	ADP
ajlm-988	35	2	these	these	DET
ajlm-988	35	3	cases	case	NOUN
ajlm-988	35	4	,	,	PUNCT
ajlm-988	35	5	more	more	ADV
ajlm-988	35	6	complex	complex	ADJ
ajlm-988	35	7	molecular	molecular	ADJ
ajlm-988	35	8	techniques	technique	NOUN
ajlm-988	35	9	are	be	AUX
ajlm-988	35	10	required	require	VERB
ajlm-988	35	11	in	in	ADP
ajlm-988	35	12	addition	addition	NOUN
ajlm-988	35	13	to	to	ADP
ajlm-988	35	14	sanger	sanger	PROPN
ajlm-988	35	15	sequencing	sequence	VERB
ajlm-988	35	16	for	for	ADP
ajlm-988	35	17	complete	complete	ADJ
ajlm-988	35	18	and	and	CCONJ
ajlm-988	35	19	accurate	accurate	ADJ
ajlm-988	35	20	haplotyping.17	haplotyping.17	PROPN
ajlm-988	35	21	these	these	PRON
ajlm-988	35	22	include	include	VERB
ajlm-988	35	23	rflp	rflp	NOUN
ajlm-988	35	24	or	or	CCONJ
ajlm-988	35	25	amplification	amplification	NOUN
ajlm-988	35	26	-	-	PUNCT
ajlm-988	35	27	refractory	refractory	NOUN
ajlm-988	35	28	mutation	mutation	NOUN
ajlm-988	35	29	system	system	NOUN
ajlm-988	35	30	(	(	PUNCT
ajlm-988	35	31	arms	arm	NOUN
ajlm-988	35	32	)	)	PUNCT
ajlm-988	35	33	amplification.18	amplification.18	NOUN
ajlm-988	35	34	these	these	DET
ajlm-988	35	35	methods	method	NOUN
ajlm-988	35	36	are	be	AUX
ajlm-988	35	37	tedious	tedious	ADJ
ajlm-988	35	38	for	for	ADP
ajlm-988	35	39	implementation	implementation	NOUN
ajlm-988	35	40	in	in	ADP
ajlm-988	35	41	a	a	DET
ajlm-988	35	42	routine	routine	ADJ
ajlm-988	35	43	diagnostic	diagnostic	ADJ
ajlm-988	35	44	laboratory	laboratory	NOUN
ajlm-988	35	45	,	,	PUNCT
ajlm-988	35	46	and	and	CCONJ
ajlm-988	35	47	therefore	therefore	ADV
ajlm-988	35	48	computational	computational	ADJ
ajlm-988	35	49	haplotype	haplotype	NOUN
ajlm-988	35	50	reconstruction	reconstruction	NOUN
ajlm-988	35	51	programs	program	NOUN
ajlm-988	35	52	have	have	AUX
ajlm-988	35	53	been	be	AUX
ajlm-988	35	54	developed	develop	VERB
ajlm-988	35	55	that	that	PRON
ajlm-988	35	56	statistically	statistically	ADV
ajlm-988	35	57	predict	predict	VERB
ajlm-988	35	58	the	the	DET
ajlm-988	35	59	most	most	ADV
ajlm-988	35	60	likely	likely	ADJ
ajlm-988	35	61	haplotype	haplotype	NOUN
ajlm-988	35	62	present	present	ADJ
ajlm-988	35	63	using	use	VERB
ajlm-988	35	64	algorithms	algorithm	NOUN
ajlm-988	35	65	that	that	PRON
ajlm-988	35	66	take	take	VERB
ajlm-988	35	67	into	into	ADP
ajlm-988	35	68	account	account	NOUN
ajlm-988	35	69	established	establish	VERB
ajlm-988	35	70	allele	allele	NOUN
ajlm-988	35	71	frequencies	frequency	NOUN
ajlm-988	35	72	within	within	ADP
ajlm-988	35	73	the	the	DET
ajlm-988	35	74	population	population	NOUN
ajlm-988	35	75	.	.	PUNCT
ajlm-988	36	1	the	the	DET
ajlm-988	36	2	computational	computational	ADJ
ajlm-988	36	3	algorithms	algorithm	NOUN
ajlm-988	36	4	offer	offer	VERB
ajlm-988	36	5	a	a	DET
ajlm-988	36	6	quicker	quick	ADJ
ajlm-988	36	7	,	,	PUNCT
ajlm-988	36	8	cheaper	cheap	ADJ
ajlm-988	36	9	and	and	CCONJ
ajlm-988	36	10	more	more	ADV
ajlm-988	36	11	practical	practical	ADJ
ajlm-988	36	12	alternative	alternative	NOUN
ajlm-988	36	13	.	.	PUNCT
ajlm-988	37	1	several	several	ADJ
ajlm-988	37	2	approaches	approach	NOUN
ajlm-988	37	3	are	be	AUX
ajlm-988	37	4	available	available	ADJ
ajlm-988	37	5	,	,	PUNCT
ajlm-988	37	6	including	include	VERB
ajlm-988	37	7	clark	clark	NOUN
ajlm-988	37	8	’s	’s	PART
ajlm-988	37	9	algorithm	algorithm	NOUN
ajlm-988	37	10	,	,	PUNCT
ajlm-988	37	11	the	the	DET
ajlm-988	37	12	expectation	expectation	NOUN
ajlm-988	37	13	maximum	maximum	ADJ
ajlm-988	37	14	algorithm	algorithm	NOUN
ajlm-988	37	15	and	and	CCONJ
ajlm-988	37	16	the	the	DET
ajlm-988	37	17	bayesian	bayesian	NOUN
ajlm-988	37	18	implementation	implementation	NOUN
ajlm-988	37	19	,	,	PUNCT
ajlm-988	37	20	which	which	PRON
ajlm-988	37	21	estimate	estimate	VERB
ajlm-988	37	22	the	the	DET
ajlm-988	37	23	maximum	maximum	ADJ
ajlm-988	37	24	likelihood	likelihood	NOUN
ajlm-988	37	25	of	of	ADP
ajlm-988	37	26	haplotype	haplotype	NOUN
ajlm-988	37	27	frequencies.19	frequencies.19	NOUN
ajlm-988	37	28	the	the	DET
ajlm-988	37	29	software	software	NOUN
ajlm-988	37	30	program	program	NOUN
ajlm-988	37	31	phase	phase	NOUN
ajlm-988	37	32	(	(	PUNCT
ajlm-988	37	33	used	use	VERB
ajlm-988	37	34	in	in	ADP
ajlm-988	37	35	this	this	DET
ajlm-988	37	36	study	study	NOUN
ajlm-988	37	37	)	)	PUNCT
ajlm-988	37	38	is	be	AUX
ajlm-988	37	39	considered	consider	VERB
ajlm-988	37	40	to	to	PART
ajlm-988	37	41	be	be	AUX
ajlm-988	37	42	the	the	DET
ajlm-988	37	43	reference	reference	NOUN
ajlm-988	37	44	standard	standard	NOUN
ajlm-988	37	45	for	for	ADP
ajlm-988	37	46	computational	computational	ADJ
ajlm-988	37	47	haplotype	haplotype	NOUN
ajlm-988	37	48	inference.20,21	inference.20,21	NOUN
ajlm-988	37	49	it	it	PRON
ajlm-988	37	50	utilises	utilise	VERB
ajlm-988	37	51	the	the	DET
ajlm-988	37	52	bayesian	bayesian	NOUN
ajlm-988	37	53	approach	approach	NOUN
ajlm-988	37	54	for	for	ADP
ajlm-988	37	55	reconstructing	reconstruct	VERB
ajlm-988	37	56	haplotypes	haplotype	NOUN
ajlm-988	37	57	based	base	VERB
ajlm-988	37	58	on	on	ADP
ajlm-988	37	59	population	population	NOUN
ajlm-988	37	60	genotype	genotype	NOUN
ajlm-988	37	61	data	datum	NOUN
ajlm-988	37	62	.	.	PUNCT
ajlm-988	38	1	using	use	VERB
ajlm-988	38	2	prior	prior	ADJ
ajlm-988	38	3	information	information	NOUN
ajlm-988	38	4	(	(	PUNCT
ajlm-988	38	5	based	base	VERB
ajlm-988	38	6	on	on	ADP
ajlm-988	38	7	beliefs	belief	NOUN
ajlm-988	38	8	about	about	ADP
ajlm-988	38	9	patterns	pattern	NOUN
ajlm-988	38	10	of	of	ADP
ajlm-988	38	11	haplotypes	haplotype	NOUN
ajlm-988	38	12	expected	expect	VERB
ajlm-988	38	13	in	in	ADP
ajlm-988	38	14	certain	certain	ADJ
ajlm-988	38	15	population	population	NOUN
ajlm-988	38	16	samples	sample	NOUN
ajlm-988	38	17	)	)	PUNCT
ajlm-988	38	18	,	,	PUNCT
ajlm-988	38	19	as	as	ADV
ajlm-988	38	20	well	well	ADV
ajlm-988	38	21	as	as	ADP
ajlm-988	38	22	the	the	DET
ajlm-988	38	23	information	information	NOUN
ajlm-988	38	24	obtained	obtain	VERB
ajlm-988	38	25	from	from	ADP
ajlm-988	38	26	the	the	DET
ajlm-988	38	27	observed	observe	VERB
ajlm-988	38	28	data	datum	NOUN
ajlm-988	38	29	,	,	PUNCT
ajlm-988	38	30	the	the	DET
ajlm-988	38	31	most	most	ADV
ajlm-988	38	32	likely	likely	ADJ
ajlm-988	38	33	haplotype	haplotype	NOUN
ajlm-988	38	34	is	be	AUX
ajlm-988	38	35	estimated	estimate	VERB
ajlm-988	38	36	and	and	CCONJ
ajlm-988	38	37	reconstructed	reconstruct	VERB
ajlm-988	38	38	for	for	ADP
ajlm-988	38	39	each	each	DET
ajlm-988	38	40	allele	allele	NOUN
ajlm-988	38	41	in	in	ADP
ajlm-988	38	42	each	each	DET
ajlm-988	38	43	individual.22	individual.22	NOUN
ajlm-988	38	44	the	the	DET
ajlm-988	38	45	proportions	proportion	NOUN
ajlm-988	38	46	of	of	ADP
ajlm-988	38	47	slow	slow	ADJ
ajlm-988	38	48	and	and	CCONJ
ajlm-988	38	49	fast	fast	ADJ
ajlm-988	38	50	acetylators	acetylator	NOUN
ajlm-988	38	51	differ	differ	VERB
ajlm-988	38	52	among	among	ADP
ajlm-988	38	53	various	various	ADJ
ajlm-988	38	54	populations	population	NOUN
ajlm-988	38	55	.	.	PUNCT
ajlm-988	39	1	in	in	ADP
ajlm-988	39	2	addition	addition	NOUN
ajlm-988	39	3	,	,	PUNCT
ajlm-988	39	4	the	the	DET
ajlm-988	39	5	effect	effect	NOUN
ajlm-988	39	6	of	of	ADP
ajlm-988	39	7	different	different	ADJ
ajlm-988	39	8	acetylation	acetylation	NOUN
ajlm-988	39	9	phenotypes	phenotype	NOUN
ajlm-988	39	10	on	on	ADP
ajlm-988	39	11	isoniazid	isoniazid	NOUN
ajlm-988	39	12	-	-	PUNCT
ajlm-988	39	13	induced	induce	VERB
ajlm-988	39	14	hepatic	hepatic	ADJ
ajlm-988	39	15	toxicity	toxicity	NOUN
ajlm-988	39	16	has	have	AUX
ajlm-988	39	17	been	be	AUX
ajlm-988	39	18	shown	show	VERB
ajlm-988	39	19	to	to	PART
ajlm-988	39	20	be	be	AUX
ajlm-988	39	21	inconsistent	inconsistent	ADJ
ajlm-988	39	22	across	across	ADP
ajlm-988	39	23	ethnic	ethnic	ADJ
ajlm-988	39	24	groups.23	groups.23	NOUN
ajlm-988	39	25	there	there	PRON
ajlm-988	39	26	is	be	VERB
ajlm-988	39	27	limited	limited	ADJ
ajlm-988	39	28	nat2	nat2	NOUN
ajlm-988	39	29	genotypic	genotypic	NOUN
ajlm-988	39	30	data	datum	NOUN
ajlm-988	39	31	in	in	ADP
ajlm-988	39	32	african	african	ADJ
ajlm-988	39	33	populations	population	NOUN
ajlm-988	39	34	;	;	PUNCT
ajlm-988	39	35	the	the	DET
ajlm-988	39	36	few	few	ADJ
ajlm-988	39	37	known	know	VERB
ajlm-988	39	38	demonstrate	demonstrate	NOUN
ajlm-988	39	39	nucleotide	nucleotide	NOUN
ajlm-988	39	40	variants	variant	NOUN
ajlm-988	39	41	that	that	PRON
ajlm-988	39	42	differ	differ	VERB
ajlm-988	39	43	from	from	ADP
ajlm-988	39	44	those	those	PRON
ajlm-988	39	45	commonly	commonly	ADV
ajlm-988	39	46	described	describe	VERB
ajlm-988	39	47	in	in	ADP
ajlm-988	39	48	european	european	ADJ
ajlm-988	39	49	populations	population	NOUN
ajlm-988	39	50	.	.	PUNCT
ajlm-988	40	1	african	african	ADJ
ajlm-988	40	2	populations	population	NOUN
ajlm-988	40	3	are	be	AUX
ajlm-988	40	4	genetically	genetically	ADV
ajlm-988	40	5	diverse,24	diverse,24	NOUN
ajlm-988	40	6	and	and	CCONJ
ajlm-988	40	7	data	datum	NOUN
ajlm-988	40	8	can	can	AUX
ajlm-988	40	9	therefore	therefore	ADV
ajlm-988	40	10	not	not	PART
ajlm-988	40	11	be	be	AUX
ajlm-988	40	12	extrapolated	extrapolate	VERB
ajlm-988	40	13	among	among	ADP
ajlm-988	40	14	the	the	DET
ajlm-988	40	15	various	various	ADJ
ajlm-988	40	16	population	population	NOUN
ajlm-988	40	17	groups	group	NOUN
ajlm-988	40	18	.	.	PUNCT
ajlm-988	41	1	the	the	DET
ajlm-988	41	2	south	south	ADJ
ajlm-988	41	3	african	african	ADJ
ajlm-988	41	4	mixed	mixed	ADJ
ajlm-988	41	5	ancestry	ancestry	NOUN
ajlm-988	41	6	population	population	NOUN
ajlm-988	41	7	(	(	PUNCT
ajlm-988	41	8	8.9	8.9	NUM
ajlm-988	41	9	%	%	NOUN
ajlm-988	41	10	of	of	ADP
ajlm-988	41	11	the	the	DET
ajlm-988	41	12	south	south	ADJ
ajlm-988	41	13	african	african	ADJ
ajlm-988	41	14	population	population	NOUN
ajlm-988	41	15	)	)	PUNCT
ajlm-988	41	16	is	be	AUX
ajlm-988	41	17	described	describe	VERB
ajlm-988	41	18	as	as	ADP
ajlm-988	41	19	a	a	DET
ajlm-988	41	20	distinct	distinct	ADJ
ajlm-988	41	21	ethnic	ethnic	ADJ
ajlm-988	41	22	group	group	NOUN
ajlm-988	41	23	with	with	ADP
ajlm-988	41	24	a	a	DET
ajlm-988	41	25	complex	complex	ADJ
ajlm-988	41	26	genetic	genetic	ADJ
ajlm-988	41	27	admixture,25	admixture,25	NOUN
ajlm-988	41	28	with	with	ADP
ajlm-988	41	29	over	over	ADP
ajlm-988	41	30	60	60	NUM
ajlm-988	41	31	%	%	NOUN
ajlm-988	41	32	living	live	VERB
ajlm-988	41	33	in	in	ADP
ajlm-988	41	34	the	the	DET
ajlm-988	41	35	western	western	ADJ
ajlm-988	41	36	cape	cape	NOUN
ajlm-988	41	37	and	and	CCONJ
ajlm-988	41	38	particularly	particularly	ADV
ajlm-988	41	39	in	in	ADP
ajlm-988	41	40	the	the	DET
ajlm-988	41	41	cape	cape	NOUN
ajlm-988	41	42	town	town	NOUN
ajlm-988	41	43	area	area	NOUN
ajlm-988	41	44	.	.	PUNCT
ajlm-988	42	1	the	the	DET
ajlm-988	42	2	major	major	ADJ
ajlm-988	42	3	ancestral	ancestral	ADJ
ajlm-988	42	4	populations	population	NOUN
ajlm-988	42	5	contributing	contribute	VERB
ajlm-988	42	6	to	to	ADP
ajlm-988	42	7	the	the	DET
ajlm-988	42	8	genetic	genetic	ADJ
ajlm-988	42	9	diversity	diversity	NOUN
ajlm-988	42	10	of	of	ADP
ajlm-988	42	11	this	this	DET
ajlm-988	42	12	group	group	NOUN
ajlm-988	42	13	include	include	VERB
ajlm-988	42	14	khoisan	khoisan	ADJ
ajlm-988	42	15	and	and	CCONJ
ajlm-988	42	16	non	non	ADJ
ajlm-988	42	17	-	-	ADJ
ajlm-988	42	18	khoisan	khoisan	ADJ
ajlm-988	42	19	africans	africans	PROPN
ajlm-988	42	20	,	,	PUNCT
ajlm-988	42	21	with	with	ADP
ajlm-988	42	22	smaller	small	ADJ
ajlm-988	42	23	contributions	contribution	NOUN
ajlm-988	42	24	from	from	ADP
ajlm-988	42	25	both	both	CCONJ
ajlm-988	42	26	european	european	ADJ
ajlm-988	42	27	and	and	CCONJ
ajlm-988	42	28	indian	indian	ADJ
ajlm-988	42	29	asian	asian	ADJ
ajlm-988	42	30	descent	descent	NOUN
ajlm-988	42	31	populations.26	populations.26	VERB
ajlm-988	42	32	the	the	DET
ajlm-988	42	33	genotypic	genotypic	NOUN
ajlm-988	42	34	complexity	complexity	NOUN
ajlm-988	42	35	and	and	CCONJ
ajlm-988	42	36	origin	origin	NOUN
ajlm-988	42	37	of	of	ADP
ajlm-988	42	38	this	this	DET
ajlm-988	42	39	population	population	NOUN
ajlm-988	42	40	not	not	PART
ajlm-988	42	41	only	only	ADV
ajlm-988	42	42	influence	influence	NOUN
ajlm-988	42	43	disease	disease	NOUN
ajlm-988	42	44	susceptibility,27	susceptibility,27	NOUN
ajlm-988	42	45	but	but	CCONJ
ajlm-988	42	46	may	may	AUX
ajlm-988	42	47	also	also	ADV
ajlm-988	42	48	have	have	VERB
ajlm-988	42	49	implications	implication	NOUN
ajlm-988	42	50	when	when	SCONJ
ajlm-988	42	51	computational	computational	ADJ
ajlm-988	42	52	haplotype	haplotype	NOUN
ajlm-988	42	53	prediction	prediction	NOUN
ajlm-988	42	54	algorithms	algorithm	NOUN
ajlm-988	42	55	are	be	AUX
ajlm-988	42	56	employed	employ	VERB
ajlm-988	42	57	.	.	PUNCT
ajlm-988	43	1	it	it	PRON
ajlm-988	43	2	would	would	AUX
ajlm-988	43	3	be	be	AUX
ajlm-988	43	4	ideal	ideal	ADJ
ajlm-988	43	5	to	to	PART
ajlm-988	43	6	determine	determine	VERB
ajlm-988	43	7	the	the	DET
ajlm-988	43	8	nat2	nat2	NOUN
ajlm-988	43	9	acetylation	acetylation	NOUN
ajlm-988	43	10	status	status	NOUN
ajlm-988	43	11	of	of	ADP
ajlm-988	43	12	each	each	DET
ajlm-988	43	13	patient	patient	NOUN
ajlm-988	43	14	in	in	ADP
ajlm-988	43	15	order	order	NOUN
ajlm-988	43	16	to	to	PART
ajlm-988	43	17	individualise	individualise	VERB
ajlm-988	43	18	isoniazid	isoniazid	NOUN
ajlm-988	43	19	therapy	therapy	NOUN
ajlm-988	43	20	.	.	PUNCT
ajlm-988	44	1	however	however	ADV
ajlm-988	44	2	,	,	PUNCT
ajlm-988	44	3	the	the	DET
ajlm-988	44	4	complex	complex	ADJ
ajlm-988	44	5	manual	manual	ADJ
ajlm-988	44	6	molecular	molecular	ADJ
ajlm-988	44	7	haplotyping	haplotyping	ADJ
ajlm-988	44	8	techniques	technique	NOUN
ajlm-988	44	9	are	be	AUX
ajlm-988	44	10	expensive	expensive	ADJ
ajlm-988	44	11	,	,	PUNCT
ajlm-988	44	12	time	time	NOUN
ajlm-988	44	13	-	-	PUNCT
ajlm-988	44	14	consuming	consume	VERB
ajlm-988	44	15	and	and	CCONJ
ajlm-988	44	16	tedious,17	tedious,17	NOUN
ajlm-988	44	17	and	and	CCONJ
ajlm-988	44	18	are	be	AUX
ajlm-988	44	19	thus	thus	ADV
ajlm-988	44	20	not	not	PART
ajlm-988	44	21	realistically	realistically	ADV
ajlm-988	44	22	feasible	feasible	ADJ
ajlm-988	44	23	in	in	ADP
ajlm-988	44	24	a	a	DET
ajlm-988	44	25	high	high	ADJ
ajlm-988	44	26	tuberculosis	tuberculosis	NOUN
ajlm-988	44	27	burden	burden	NOUN
ajlm-988	44	28	setting	set	VERB
ajlm-988	44	29	such	such	ADJ
ajlm-988	44	30	as	as	ADP
ajlm-988	44	31	the	the	DET
ajlm-988	44	32	western	western	ADJ
ajlm-988	44	33	cape	cape	NOUN
ajlm-988	44	34	where	where	SCONJ
ajlm-988	44	35	this	this	DET
ajlm-988	44	36	study	study	NOUN
ajlm-988	44	37	was	be	AUX
ajlm-988	44	38	performed	perform	VERB
ajlm-988	44	39	.	.	PUNCT
ajlm-988	45	1	while	while	SCONJ
ajlm-988	45	2	the	the	DET
ajlm-988	45	3	phase	phase	NOUN
ajlm-988	45	4	computational	computational	ADJ
ajlm-988	45	5	algorithm	algorithm	NOUN
ajlm-988	45	6	is	be	AUX
ajlm-988	45	7	used	use	VERB
ajlm-988	45	8	routinely	routinely	ADV
ajlm-988	45	9	at	at	ADP
ajlm-988	45	10	many	many	ADJ
ajlm-988	45	11	centres	centre	NOUN
ajlm-988	45	12	,	,	PUNCT
ajlm-988	45	13	its	its	PRON
ajlm-988	45	14	performance	performance	NOUN
ajlm-988	45	15	has	have	AUX
ajlm-988	45	16	not	not	PART
ajlm-988	45	17	been	be	AUX
ajlm-988	45	18	validated	validate	VERB
ajlm-988	45	19	in	in	ADP
ajlm-988	45	20	the	the	DET
ajlm-988	45	21	south	south	ADJ
ajlm-988	45	22	african	african	ADJ
ajlm-988	45	23	mixed	mixed	ADJ
ajlm-988	45	24	ancestry	ancestry	NOUN
ajlm-988	45	25	population	population	NOUN
ajlm-988	45	26	.	.	PUNCT
ajlm-988	46	1	this	this	DET
ajlm-988	46	2	study	study	NOUN
ajlm-988	46	3	aims	aim	VERB
ajlm-988	46	4	to	to	PART
ajlm-988	46	5	describe	describe	VERB
ajlm-988	46	6	the	the	DET
ajlm-988	46	7	nat2	nat2	NOUN
ajlm-988	46	8	haplotypes	haplotype	NOUN
ajlm-988	46	9	identified	identify	VERB
ajlm-988	46	10	in	in	ADP
ajlm-988	46	11	this	this	DET
ajlm-988	46	12	population	population	NOUN
ajlm-988	46	13	and	and	CCONJ
ajlm-988	46	14	to	to	PART
ajlm-988	46	15	assess	assess	VERB
ajlm-988	46	16	the	the	DET
ajlm-988	46	17	accuracy	accuracy	NOUN
ajlm-988	46	18	of	of	ADP
ajlm-988	46	19	phase	phase	NOUN
ajlm-988	46	20	version	version	NOUN
ajlm-988	46	21	2.1.1	2.1.1	NUM
ajlm-988	46	22	in	in	ADP
ajlm-988	46	23	assigning	assign	VERB
ajlm-988	46	24	nat2	nat2	NOUN
ajlm-988	46	25	haplotypes	haplotype	NOUN
ajlm-988	46	26	in	in	ADP
ajlm-988	46	27	the	the	DET
ajlm-988	46	28	mixed	mixed	ADJ
ajlm-988	46	29	ancestry	ancestry	NOUN
ajlm-988	46	30	population	population	NOUN
ajlm-988	46	31	of	of	ADP
ajlm-988	46	32	the	the	DET
ajlm-988	46	33	western	western	ADJ
ajlm-988	46	34	cape	cape	NOUN
ajlm-988	46	35	.	.	PUNCT
ajlm-988	47	1	methods	method	NOUN
ajlm-988	47	2	ethical	ethical	ADJ
ajlm-988	47	3	considerations	consideration	NOUN
ajlm-988	47	4	the	the	DET
ajlm-988	47	5	human	human	ADJ
ajlm-988	47	6	research	research	PROPN
ajlm-988	47	7	ethics	ethic	NOUN
ajlm-988	47	8	committee	committee	PROPN
ajlm-988	47	9	(	(	PUNCT
ajlm-988	47	10	hrec	hrec	PROPN
ajlm-988	47	11	ref	ref	PROPN
ajlm-988	47	12	:	:	PUNCT
ajlm-988	47	13	327/2014	327/2014	NUM
ajlm-988	47	14	)	)	PUNCT
ajlm-988	47	15	,	,	PUNCT
ajlm-988	47	16	appointed	appoint	VERB
ajlm-988	47	17	by	by	ADP
ajlm-988	47	18	the	the	DET
ajlm-988	47	19	faculty	faculty	NOUN
ajlm-988	47	20	of	of	ADP
ajlm-988	47	21	health	health	NOUN
ajlm-988	47	22	sciences	science	NOUN
ajlm-988	47	23	at	at	ADP
ajlm-988	47	24	the	the	DET
ajlm-988	47	25	university	university	PROPN
ajlm-988	47	26	of	of	ADP
ajlm-988	47	27	cape	cape	PROPN
ajlm-988	47	28	town	town	NOUN
ajlm-988	47	29	,	,	PUNCT
ajlm-988	47	30	approved	approve	VERB
ajlm-988	47	31	this	this	DET
ajlm-988	47	32	study	study	NOUN
ajlm-988	47	33	.	.	PUNCT
ajlm-988	48	1	all	all	DET
ajlm-988	48	2	the	the	DET
ajlm-988	48	3	work	work	NOUN
ajlm-988	48	4	conducted	conduct	VERB
ajlm-988	48	5	was	be	AUX
ajlm-988	48	6	performed	perform	VERB
ajlm-988	48	7	on	on	ADP
ajlm-988	48	8	pre	pre	VERB
ajlm-988	48	9	-	-	VERB
ajlm-988	48	10	extracted	extract	VERB
ajlm-988	48	11	,	,	PUNCT
ajlm-988	48	12	stored	store	VERB
ajlm-988	48	13	dna	dna	NOUN
ajlm-988	48	14	from	from	ADP
ajlm-988	48	15	participants	participant	NOUN
ajlm-988	48	16	who	who	PRON
ajlm-988	48	17	gave	give	VERB
ajlm-988	48	18	informed	informed	ADJ
ajlm-988	48	19	consent	consent	NOUN
ajlm-988	48	20	for	for	ADP
ajlm-988	48	21	research	research	NOUN
ajlm-988	48	22	conducted	conduct	VERB
ajlm-988	48	23	in	in	ADP
ajlm-988	48	24	a	a	DET
ajlm-988	48	25	previous	previous	ADJ
ajlm-988	48	26	study	study	NOUN
ajlm-988	48	27	,	,	PUNCT
ajlm-988	48	28	as	as	ADV
ajlm-988	48	29	well	well	ADV
ajlm-988	48	30	as	as	ADP
ajlm-988	48	31	for	for	ADP
ajlm-988	48	32	any	any	DET
ajlm-988	48	33	future	future	ADJ
ajlm-988	48	34	molecular	molecular	ADJ
ajlm-988	48	35	testing	testing	NOUN
ajlm-988	48	36	.	.	PUNCT
ajlm-988	49	1	the	the	DET
ajlm-988	49	2	dna	dna	PROPN
ajlm-988	49	3	samples	sample	NOUN
ajlm-988	49	4	were	be	AUX
ajlm-988	49	5	selected	select	VERB
ajlm-988	49	6	at	at	ADP
ajlm-988	49	7	random	random	ADJ
ajlm-988	49	8	from	from	ADP
ajlm-988	49	9	participants	participant	NOUN
ajlm-988	49	10	of	of	ADP
ajlm-988	49	11	self	self	NOUN
ajlm-988	49	12	-	-	PUNCT
ajlm-988	49	13	identified	identify	VERB
ajlm-988	49	14	mixed	mixed	ADJ
ajlm-988	49	15	ancestry	ancestry	NOUN
ajlm-988	49	16	by	by	ADP
ajlm-988	49	17	allocation	allocation	NOUN
ajlm-988	49	18	of	of	ADP
ajlm-988	49	19	numbers	number	NOUN
ajlm-988	49	20	only	only	ADV
ajlm-988	49	21	.	.	PUNCT
ajlm-988	50	1	study	study	NOUN
ajlm-988	50	2	site	site	NOUN
ajlm-988	50	3	and	and	CCONJ
ajlm-988	50	4	population	population	NOUN
ajlm-988	50	5	this	this	DET
ajlm-988	50	6	study	study	NOUN
ajlm-988	50	7	was	be	AUX
ajlm-988	50	8	conducted	conduct	VERB
ajlm-988	50	9	between	between	ADP
ajlm-988	50	10	2013	2013	NUM
ajlm-988	50	11	and	and	CCONJ
ajlm-988	50	12	2016	2016	NUM
ajlm-988	50	13	.	.	PUNCT
ajlm-988	51	1	the	the	DET
ajlm-988	51	2	blood	blood	NOUN
ajlm-988	51	3	samples	sample	NOUN
ajlm-988	51	4	(	(	PUNCT
ajlm-988	51	5	n	n	NOUN
ajlm-988	51	6	=	=	SYM
ajlm-988	51	7	100	100	NUM
ajlm-988	51	8	)	)	PUNCT
ajlm-988	51	9	used	use	VERB
ajlm-988	51	10	in	in	ADP
ajlm-988	51	11	this	this	DET
ajlm-988	51	12	study	study	NOUN
ajlm-988	51	13	were	be	AUX
ajlm-988	51	14	sourced	source	VERB
ajlm-988	51	15	with	with	ADP
ajlm-988	51	16	informed	informed	ADJ
ajlm-988	51	17	consent	consent	NOUN
ajlm-988	51	18	from	from	ADP
ajlm-988	51	19	randomly	randomly	ADV
ajlm-988	51	20	selected	select	VERB
ajlm-988	51	21	,	,	PUNCT
ajlm-988	51	22	self	self	NOUN
ajlm-988	51	23	-	-	PUNCT
ajlm-988	51	24	identified	identify	VERB
ajlm-988	51	25	mixed	mixed	ADJ
ajlm-988	51	26	ancestry	ancestry	NOUN
ajlm-988	51	27	adult	adult	NOUN
ajlm-988	51	28	patients	patient	NOUN
ajlm-988	51	29	attending	attend	VERB
ajlm-988	51	30	the	the	DET
ajlm-988	51	31	lipid	lipid	NOUN
ajlm-988	51	32	outpatients	outpatient	NOUN
ajlm-988	51	33	’	'	PUNCT
ajlm-988	51	34	clinic	clinic	NOUN
ajlm-988	51	35	at	at	ADP
ajlm-988	51	36	groote	groote	PROPN
ajlm-988	51	37	schuur	schuur	PROPN
ajlm-988	51	38	hospital	hospital	PROPN
ajlm-988	51	39	in	in	ADP
ajlm-988	51	40	cape	cape	NOUN
ajlm-988	51	41	town	town	NOUN
ajlm-988	51	42	,	,	PUNCT
ajlm-988	51	43	south	south	PROPN
ajlm-988	51	44	africa	africa	PROPN
ajlm-988	51	45	.	.	PUNCT
ajlm-988	52	1	dna	dna	PROPN
ajlm-988	52	2	was	be	AUX
ajlm-988	52	3	extracted	extract	VERB
ajlm-988	52	4	and	and	CCONJ
ajlm-988	52	5	stored	store	VERB
ajlm-988	52	6	.	.	PUNCT
ajlm-988	53	1	molecular	molecular	ADJ
ajlm-988	53	2	techniques	technique	NOUN
ajlm-988	53	3	the	the	DET
ajlm-988	53	4	nat2	nat2	NOUN
ajlm-988	53	5	gene	gene	NOUN
ajlm-988	53	6	was	be	AUX
ajlm-988	53	7	amplified	amplify	VERB
ajlm-988	53	8	by	by	ADP
ajlm-988	53	9	polymerase	polymerase	NOUN
ajlm-988	53	10	chain	chain	NOUN
ajlm-988	53	11	reaction	reaction	NOUN
ajlm-988	53	12	(	(	PUNCT
ajlm-988	53	13	pcr	pcr	PROPN
ajlm-988	53	14	)	)	PUNCT
ajlm-988	53	15	,	,	PUNCT
ajlm-988	53	16	sequenced	sequence	VERB
ajlm-988	53	17	(	(	PUNCT
ajlm-988	53	18	using	use	VERB
ajlm-988	53	19	sanger	sanger	PROPN
ajlm-988	53	20	sequencing	sequencing	NOUN
ajlm-988	53	21	)	)	PUNCT
ajlm-988	53	22	and	and	CCONJ
ajlm-988	53	23	haplotyped	haplotype	VERB
ajlm-988	53	24	using	use	VERB
ajlm-988	53	25	molecular	molecular	ADJ
ajlm-988	53	26	and	and	CCONJ
ajlm-988	53	27	computational	computational	ADJ
ajlm-988	53	28	techniques	technique	NOUN
ajlm-988	53	29	as	as	SCONJ
ajlm-988	53	30	described	describe	VERB
ajlm-988	53	31	below	below	ADV
ajlm-988	53	32	.	.	PUNCT
ajlm-988	54	1	polymerase	polymerase	NOUN
ajlm-988	54	2	chain	chain	NOUN
ajlm-988	54	3	reaction	reaction	NOUN
ajlm-988	54	4	the	the	DET
ajlm-988	54	5	pcr	pcr	NOUN
ajlm-988	54	6	was	be	AUX
ajlm-988	54	7	performed	perform	VERB
ajlm-988	54	8	using	use	VERB
ajlm-988	54	9	primers	primer	NOUN
ajlm-988	54	10	designed	design	VERB
ajlm-988	54	11	to	to	PART
ajlm-988	54	12	flank	flank	VERB
ajlm-988	54	13	the	the	DET
ajlm-988	54	14	entire	entire	ADJ
ajlm-988	54	15	coding	code	VERB
ajlm-988	54	16	region	region	NOUN
ajlm-988	54	17	of	of	ADP
ajlm-988	54	18	the	the	DET
ajlm-988	54	19	nat2	nat2	NOUN
ajlm-988	54	20	gene	gene	NOUN
ajlm-988	54	21	(	(	PUNCT
ajlm-988	54	22	pcr	pcr	ADJ
ajlm-988	54	23	amplicon	amplicon	NOUN
ajlm-988	54	24	size	size	NOUN
ajlm-988	54	25	1003	1003	NUM
ajlm-988	54	26	bp	bp	PROPN
ajlm-988	54	27	)	)	PUNCT
ajlm-988	54	28	.	.	PUNCT
ajlm-988	55	1	the	the	DET
ajlm-988	55	2	reaction	reaction	NOUN
ajlm-988	55	3	consisted	consist	VERB
ajlm-988	55	4	of	of	ADP
ajlm-988	55	5	the	the	DET
ajlm-988	55	6	appropriate	appropriate	ADJ
ajlm-988	55	7	forward	forward	ADV
ajlm-988	55	8	(	(	PUNCT
ajlm-988	55	9	5′gtcacacgaggaaatcaaatgc3′	5′gtcacacgaggaaatcaaatgc3′	NUM
ajlm-988	55	10	)	)	PUNCT
ajlm-988	55	11	and	and	CCONJ
ajlm-988	55	12	reverse	reverse	VERB
ajlm-988	55	13	(	(	PUNCT
ajlm-988	55	14	5′agttgataattagtgagttgggtga3′	5′agttgataattagtgagttgggtga3′	NUM
ajlm-988	55	15	)	)	PUNCT
ajlm-988	55	16	nat2	nat2	NOUN
ajlm-988	55	17	primers	primer	NOUN
ajlm-988	55	18	(	(	PUNCT
ajlm-988	55	19	0.5	0.5	NUM
ajlm-988	55	20	µm	µm	NOUN
ajlm-988	55	21	)	)	PUNCT
ajlm-988	55	22	,	,	PUNCT
ajlm-988	55	23	deoxynucleotide	deoxynucleotide	NOUN
ajlm-988	55	24	triphosphates	triphosphate	NOUN
ajlm-988	55	25	(	(	PUNCT
ajlm-988	55	26	0.2	0.2	NUM
ajlm-988	55	27	mm	mm	NOUN
ajlm-988	55	28	)	)	PUNCT
ajlm-988	55	29	,	,	PUNCT
ajlm-988	55	30	supertherm	supertherm	VERB
ajlm-988	55	31	gold	gold	NOUN
ajlm-988	55	32	taq	taq	PROPN
ajlm-988	55	33	dna	dna	NOUN
ajlm-988	55	34	polymerase	polymerase	NOUN
ajlm-988	55	35	(	(	PUNCT
ajlm-988	55	36	0.75	0.75	NUM
ajlm-988	55	37	u	u	NOUN
ajlm-988	55	38	)	)	PUNCT
ajlm-988	55	39	(	(	PUNCT
ajlm-988	55	40	jmr	jmr	PROPN
ajlm-988	55	41	holdings	holdings	PROPN
ajlm-988	55	42	,	,	PUNCT
ajlm-988	55	43	kent	kent	PROPN
ajlm-988	55	44	,	,	PUNCT
ajlm-988	55	45	united	united	ADJ
ajlm-988	55	46	kingdom	kingdom	PROPN
ajlm-988	55	47	)	)	PUNCT
ajlm-988	55	48	,	,	PUNCT
ajlm-988	55	49	1	1	NUM
ajlm-988	55	50	x	x	NOUN
ajlm-988	55	51	buffer	buffer	NOUN
ajlm-988	55	52	containing	contain	VERB
ajlm-988	55	53	mgcl2	mgcl2	NOUN
ajlm-988	55	54	at	at	ADP
ajlm-988	55	55	1.5	1.5	NUM
ajlm-988	55	56	mm	mm	NOUN
ajlm-988	55	57	final	final	ADJ
ajlm-988	55	58	concentration	concentration	NOUN
ajlm-988	55	59	(	(	PUNCT
ajlm-988	55	60	supplied	supply	VERB
ajlm-988	55	61	)	)	PUNCT
ajlm-988	55	62	and	and	CCONJ
ajlm-988	55	63	approximately	approximately	ADV
ajlm-988	55	64	50	50	NUM
ajlm-988	55	65	ng	ng	PROPN
ajlm-988	55	66	to	to	ADP
ajlm-988	55	67	150	150	NUM
ajlm-988	55	68	ng	ng	PROPN
ajlm-988	55	69	dna	dna	PROPN
ajlm-988	55	70	.	.	PUNCT
ajlm-988	56	1	polymerase	polymerase	NOUN
ajlm-988	56	2	chain	chain	NOUN
ajlm-988	56	3	reaction	reaction	NOUN
ajlm-988	56	4	cycling	cycling	NOUN
ajlm-988	56	5	conditions	condition	NOUN
ajlm-988	56	6	were	be	AUX
ajlm-988	56	7	as	as	SCONJ
ajlm-988	56	8	follows	follow	VERB
ajlm-988	56	9	:	:	PUNCT
ajlm-988	56	10	94	94	NUM
ajlm-988	56	11	°	°	NUM
ajlm-988	56	12	c	c	NOUN
ajlm-988	56	13	for	for	ADP
ajlm-988	56	14	3	3	NUM
ajlm-988	56	15	minutes	minute	NOUN
ajlm-988	56	16	;	;	PUNCT
ajlm-988	56	17	35	35	NUM
ajlm-988	56	18	cycles	cycle	NOUN
ajlm-988	56	19	of	of	ADP
ajlm-988	56	20	:	:	PUNCT
ajlm-988	56	21	94	94	NUM
ajlm-988	57	1	°	°	NUM
ajlm-988	57	2	c	c	NOUN
ajlm-988	57	3	for	for	ADP
ajlm-988	57	4	30	30	NUM
ajlm-988	57	5	s	s	NOUN
ajlm-988	57	6	,	,	PUNCT
ajlm-988	57	7	56	56	NUM
ajlm-988	57	8	°	°	NUM
ajlm-988	57	9	c	c	NOUN
ajlm-988	57	10	for	for	ADP
ajlm-988	57	11	30	30	NUM
ajlm-988	57	12	s	s	NOUN
ajlm-988	57	13	and	and	CCONJ
ajlm-988	57	14	72	72	NUM
ajlm-988	57	15	°	°	NUM
ajlm-988	57	16	c	c	NOUN
ajlm-988	57	17	for	for	ADP
ajlm-988	57	18	40	40	NUM
ajlm-988	57	19	s	s	NOUN
ajlm-988	57	20	,	,	PUNCT
ajlm-988	57	21	followed	follow	VERB
ajlm-988	57	22	by	by	ADP
ajlm-988	57	23	72	72	NUM
ajlm-988	57	24	°	°	NOUN
ajlm-988	57	25	c	c	NOUN
ajlm-988	57	26	for	for	ADP
ajlm-988	57	27	8	8	NUM
ajlm-988	57	28	min	min	PROPN
ajlm-988	57	29	.	.	PROPN
ajlm-988	57	30	reaction	reaction	NOUN
ajlm-988	57	31	efficacy	efficacy	NOUN
ajlm-988	57	32	was	be	AUX
ajlm-988	57	33	assessed	assess	VERB
ajlm-988	57	34	by	by	ADP
ajlm-988	57	35	agarose	agarose	NOUN
ajlm-988	57	36	gel	gel	NOUN
ajlm-988	57	37	electrophoresis	electrophoresis	NOUN
ajlm-988	57	38	(	(	PUNCT
ajlm-988	57	39	using	use	VERB
ajlm-988	57	40	2	2	NUM
ajlm-988	57	41	%	%	NOUN
ajlm-988	57	42	agarose	agarose	NOUN
ajlm-988	57	43	gel	gel	NOUN
ajlm-988	57	44	with	with	ADP
ajlm-988	57	45	the	the	DET
ajlm-988	57	46	addition	addition	NOUN
ajlm-988	57	47	of	of	ADP
ajlm-988	57	48	ethidium	ethidium	NOUN
ajlm-988	57	49	bromide	bromide	NOUN
ajlm-988	57	50	for	for	ADP
ajlm-988	57	51	visualisation	visualisation	NOUN
ajlm-988	57	52	)	)	PUNCT
ajlm-988	57	53	prior	prior	ADV
ajlm-988	57	54	to	to	ADP
ajlm-988	57	55	further	further	ADJ
ajlm-988	57	56	analysis	analysis	NOUN
ajlm-988	57	57	.	.	PUNCT
ajlm-988	58	1	sequencing	sequence	VERB
ajlm-988	58	2	of	of	ADP
ajlm-988	58	3	polymerase	polymerase	NOUN
ajlm-988	58	4	chain	chain	NOUN
ajlm-988	58	5	reaction	reaction	NOUN
ajlm-988	58	6	products	product	NOUN
ajlm-988	58	7	sequencing	sequence	VERB
ajlm-988	58	8	of	of	ADP
ajlm-988	58	9	the	the	DET
ajlm-988	58	10	resulting	result	VERB
ajlm-988	58	11	pcr	pcr	ADJ
ajlm-988	58	12	products	product	NOUN
ajlm-988	58	13	were	be	AUX
ajlm-988	58	14	outsourced	outsource	VERB
ajlm-988	58	15	to	to	ADP
ajlm-988	58	16	the	the	DET
ajlm-988	58	17	central	central	ADJ
ajlm-988	58	18	analytical	analytical	ADJ
ajlm-988	58	19	facility	facility	NOUN
ajlm-988	58	20	(	(	PUNCT
ajlm-988	58	21	stellenbosch	stellenbosch	PROPN
ajlm-988	58	22	university	university	PROPN
ajlm-988	58	23	,	,	PUNCT
ajlm-988	58	24	south	south	PROPN
ajlm-988	58	25	africa	africa	PROPN
ajlm-988	58	26	)	)	PUNCT
ajlm-988	58	27	.	.	PUNCT
ajlm-988	59	1	forward	forward	ADV
ajlm-988	59	2	and	and	CCONJ
ajlm-988	59	3	reverse	reverse	VERB
ajlm-988	59	4	sequencing	sequencing	NOUN
ajlm-988	59	5	were	be	AUX
ajlm-988	59	6	performed	perform	VERB
ajlm-988	59	7	.	.	PUNCT
ajlm-988	60	1	the	the	DET
ajlm-988	60	2	sequencing	sequence	VERB
ajlm-988	60	3	data	datum	NOUN
ajlm-988	60	4	were	be	AUX
ajlm-988	60	5	compared	compare	VERB
ajlm-988	60	6	to	to	ADP
ajlm-988	60	7	the	the	DET
ajlm-988	60	8	nat2	nat2	NOUN
ajlm-988	60	9	genomic	genomic	NOUN
ajlm-988	60	10	reference	reference	NOUN
ajlm-988	60	11	sequence	sequence	NOUN
ajlm-988	60	12	obtained	obtain	VERB
ajlm-988	60	13	from	from	ADP
ajlm-988	60	14	genbank	genbank	PROPN
ajlm-988	60	15	(	(	PUNCT
ajlm-988	60	16	ng_012246.1	ng_012246.1	PROPN
ajlm-988	60	17	)	)	PUNCT
ajlm-988	60	18	(	(	PUNCT
ajlm-988	60	19	https://www.ncbi.nlm.nih.gov/genbank/	https://www.ncbi.nlm.nih.gov/genbank/	NOUN
ajlm-988	60	20	)	)	PUNCT
ajlm-988	60	21	to	to	PART
ajlm-988	60	22	identify	identify	VERB
ajlm-988	60	23	all	all	DET
ajlm-988	60	24	nat2	nat2	NOUN
ajlm-988	60	25	gene	gene	NOUN
ajlm-988	60	26	variants	variant	NOUN
ajlm-988	60	27	present	present	ADJ
ajlm-988	60	28	(	(	PUNCT
ajlm-988	60	29	figure	figure	NOUN
ajlm-988	60	30	1	1	NUM
ajlm-988	60	31	and	and	CCONJ
ajlm-988	60	32	figure	figure	VERB
ajlm-988	60	33	2	2	NUM
ajlm-988	60	34	)	)	PUNCT
ajlm-988	60	35	.	.	PUNCT
ajlm-988	61	1	figure	figure	VERB
ajlm-988	61	2	1	1	NUM
ajlm-988	61	3	:	:	PUNCT
ajlm-988	61	4	electropherogram	electropherogram	NOUN
ajlm-988	61	5	demonstrating	demonstrating	NOUN
ajlm-988	61	6	heterozygosity	heterozygosity	NOUN
ajlm-988	61	7	for	for	ADP
ajlm-988	61	8	the	the	DET
ajlm-988	61	9	c.341t	c.341t	PROPN
ajlm-988	61	10	>	>	X
ajlm-988	61	11	c	c	PROPN
ajlm-988	61	12	(	(	PUNCT
ajlm-988	61	13	p.i114	p.i114	NOUN
ajlm-988	61	14	t	t	NOUN
ajlm-988	61	15	)	)	PUNCT
ajlm-988	61	16	single	single	ADJ
ajlm-988	61	17	nucleotide	nucleotide	NOUN
ajlm-988	61	18	variation	variation	NOUN
ajlm-988	61	19	,	,	PUNCT
ajlm-988	61	20	western	western	ADJ
ajlm-988	61	21	cape	cape	NOUN
ajlm-988	61	22	,	,	PUNCT
ajlm-988	61	23	south	south	PROPN
ajlm-988	61	24	africa	africa	PROPN
ajlm-988	61	25	,	,	PUNCT
ajlm-988	61	26	2013–2016	2013–2016	NUM
ajlm-988	61	27	.	.	PUNCT
ajlm-988	62	1	single	single	ADJ
ajlm-988	62	2	nucleotide	nucleotide	NOUN
ajlm-988	62	3	variants	variant	NOUN
ajlm-988	62	4	depicted	depict	VERB
ajlm-988	62	5	by	by	ADP
ajlm-988	62	6	the	the	DET
ajlm-988	62	7	red	red	ADJ
ajlm-988	62	8	‘	'	PUNCT
ajlm-988	62	9	y	y	NOUN
ajlm-988	62	10	’	'	PUNCT
ajlm-988	62	11	highlighted	highlight	VERB
ajlm-988	62	12	in	in	ADP
ajlm-988	62	13	yellow	yellow	ADJ
ajlm-988	62	14	.	.	PUNCT
ajlm-988	63	1	figure	figure	NOUN
ajlm-988	63	2	2	2	NUM
ajlm-988	63	3	:	:	PUNCT
ajlm-988	63	4	electropherogram	electropherogram	NOUN
ajlm-988	63	5	demonstrating	demonstrating	NOUN
ajlm-988	63	6	heterozygosity	heterozygosity	NOUN
ajlm-988	63	7	for	for	ADP
ajlm-988	63	8	the	the	DET
ajlm-988	63	9	c.282c	c.282c	PROPN
ajlm-988	63	10	>	>	X
ajlm-988	63	11	t	t	PROPN
ajlm-988	63	12	(	(	PUNCT
ajlm-988	63	13	p.y94y	p.y94y	PROPN
ajlm-988	63	14	)	)	PUNCT
ajlm-988	63	15	single	single	ADJ
ajlm-988	63	16	nucleotide	nucleotide	NOUN
ajlm-988	63	17	variation	variation	NOUN
ajlm-988	63	18	,	,	PUNCT
ajlm-988	63	19	western	western	ADJ
ajlm-988	63	20	cape	cape	NOUN
ajlm-988	63	21	,	,	PUNCT
ajlm-988	63	22	south	south	PROPN
ajlm-988	63	23	africa	africa	PROPN
ajlm-988	63	24	,	,	PUNCT
ajlm-988	63	25	2013–2016	2013–2016	NUM
ajlm-988	63	26	.	.	PUNCT
ajlm-988	64	1	single	single	ADJ
ajlm-988	64	2	nucleotide	nucleotide	NOUN
ajlm-988	64	3	variants	variant	NOUN
ajlm-988	64	4	depicted	depict	VERB
ajlm-988	64	5	by	by	ADP
ajlm-988	64	6	the	the	DET
ajlm-988	64	7	red	red	ADJ
ajlm-988	64	8	‘	'	PUNCT
ajlm-988	64	9	y	y	NOUN
ajlm-988	64	10	’	'	PUNCT
ajlm-988	64	11	highlighted	highlight	VERB
ajlm-988	64	12	in	in	ADP
ajlm-988	64	13	yellow	yellow	ADJ
ajlm-988	64	14	.	.	PUNCT
ajlm-988	65	1	restriction	restriction	NOUN
ajlm-988	65	2	fragment	fragment	NOUN
ajlm-988	65	3	length	length	NOUN
ajlm-988	65	4	polymorphism	polymorphism	NOUN
ajlm-988	65	5	restriction	restriction	NOUN
ajlm-988	65	6	fragment	fragment	NOUN
ajlm-988	65	7	length	length	NOUN
ajlm-988	65	8	polymorphism	polymorphism	NOUN
ajlm-988	65	9	was	be	AUX
ajlm-988	65	10	used	use	VERB
ajlm-988	65	11	to	to	PART
ajlm-988	65	12	separate	separate	VERB
ajlm-988	65	13	individual	individual	ADJ
ajlm-988	65	14	alleles	allele	NOUN
ajlm-988	65	15	in	in	ADP
ajlm-988	65	16	25	25	NUM
ajlm-988	65	17	samples	sample	NOUN
ajlm-988	65	18	with	with	ADP
ajlm-988	65	19	ambiguous	ambiguous	ADJ
ajlm-988	65	20	haplotypes	haplotype	NOUN
ajlm-988	65	21	.	.	PUNCT
ajlm-988	66	1	the	the	DET
ajlm-988	66	2	c.481c	c.481c	PROPN
ajlm-988	66	3	>	>	X
ajlm-988	66	4	t	t	PROPN
ajlm-988	66	5	and	and	CCONJ
ajlm-988	66	6	c.191g	c.191g	NOUN
ajlm-988	66	7	>	>	X
ajlm-988	66	8	a	a	DET
ajlm-988	66	9	variations	variation	NOUN
ajlm-988	66	10	destroy	destroy	VERB
ajlm-988	66	11	cleavage	cleavage	NOUN
ajlm-988	66	12	sites	site	NOUN
ajlm-988	66	13	for	for	ADP
ajlm-988	66	14	kpn1	kpn1	PROPN
ajlm-988	66	15	and	and	CCONJ
ajlm-988	66	16	msp1	msp1	PROPN
ajlm-988	66	17	.	.	PUNCT
ajlm-988	67	1	kpn1	kpn1	PROPN
ajlm-988	67	2	was	be	AUX
ajlm-988	67	3	therefore	therefore	ADV
ajlm-988	67	4	used	use	VERB
ajlm-988	67	5	in	in	ADP
ajlm-988	67	6	samples	sample	NOUN
ajlm-988	67	7	heterozygous	heterozygous	ADJ
ajlm-988	67	8	for	for	ADP
ajlm-988	67	9	c.481c	c.481c	PROPN
ajlm-988	67	10	>	>	X
ajlm-988	67	11	t	t	PROPN
ajlm-988	67	12	(	(	PUNCT
ajlm-988	67	13	n	n	NOUN
ajlm-988	67	14	=	=	SYM
ajlm-988	67	15	22	22	NUM
ajlm-988	67	16	)	)	PUNCT
ajlm-988	67	17	,	,	PUNCT
ajlm-988	67	18	while	while	SCONJ
ajlm-988	67	19	msp1	msp1	PROPN
ajlm-988	67	20	was	be	AUX
ajlm-988	67	21	used	use	VERB
ajlm-988	67	22	in	in	ADP
ajlm-988	67	23	those	those	PRON
ajlm-988	67	24	with	with	ADP
ajlm-988	67	25	heterozygous	heterozygous	ADJ
ajlm-988	67	26	c.191g	c.191g	NOUN
ajlm-988	67	27	>	>	X
ajlm-988	67	28	a	a	DET
ajlm-988	67	29	(	(	PUNCT
ajlm-988	67	30	n	n	NOUN
ajlm-988	67	31	=	=	SYM
ajlm-988	67	32	3	3	NUM
ajlm-988	67	33	)	)	PUNCT
ajlm-988	67	34	.	.	PUNCT
ajlm-988	68	1	while	while	SCONJ
ajlm-988	68	2	the	the	DET
ajlm-988	68	3	normal	normal	ADJ
ajlm-988	68	4	allele	allele	NOUN
ajlm-988	68	5	is	be	AUX
ajlm-988	68	6	recognised	recognise	VERB
ajlm-988	68	7	and	and	CCONJ
ajlm-988	68	8	digested	digest	VERB
ajlm-988	68	9	into	into	ADP
ajlm-988	68	10	two	two	NUM
ajlm-988	68	11	smaller	small	ADJ
ajlm-988	68	12	fragments	fragment	NOUN
ajlm-988	68	13	,	,	PUNCT
ajlm-988	68	14	the	the	DET
ajlm-988	68	15	affected	affected	ADJ
ajlm-988	68	16	allele	allele	NOUN
ajlm-988	68	17	is	be	AUX
ajlm-988	68	18	not	not	PART
ajlm-988	68	19	(	(	PUNCT
ajlm-988	68	20	figure	figure	NOUN
ajlm-988	68	21	3	3	NUM
ajlm-988	68	22	)	)	PUNCT
ajlm-988	68	23	.	.	PUNCT
ajlm-988	69	1	reaction	reaction	NOUN
ajlm-988	69	2	products	product	NOUN
ajlm-988	69	3	were	be	AUX
ajlm-988	69	4	separated	separate	VERB
ajlm-988	69	5	by	by	ADP
ajlm-988	69	6	agarose	agarose	NOUN
ajlm-988	69	7	gel	gel	NOUN
ajlm-988	69	8	electrophoresis	electrophoresis	NOUN
ajlm-988	69	9	(	(	PUNCT
ajlm-988	69	10	2	2	NUM
ajlm-988	69	11	%	%	NOUN
ajlm-988	69	12	)	)	PUNCT
ajlm-988	69	13	followed	follow	VERB
ajlm-988	69	14	by	by	ADP
ajlm-988	69	15	excision	excision	NOUN
ajlm-988	69	16	,	,	PUNCT
ajlm-988	69	17	agarose	agarose	NOUN
ajlm-988	69	18	gel	gel	NOUN
ajlm-988	69	19	extraction	extraction	NOUN
ajlm-988	69	20	and	and	CCONJ
ajlm-988	69	21	sequencing	sequencing	NOUN
ajlm-988	69	22	of	of	ADP
ajlm-988	69	23	the	the	DET
ajlm-988	69	24	undigested	undigested	ADJ
ajlm-988	69	25	allele	allele	NOUN
ajlm-988	69	26	.	.	PUNCT
ajlm-988	70	1	figure	figure	VERB
ajlm-988	70	2	3	3	NUM
ajlm-988	70	3	:	:	PUNCT
ajlm-988	70	4	kpn1	kpn1	PROPN
ajlm-988	70	5	restriction	restriction	NOUN
ajlm-988	70	6	fraction	fraction	NOUN
ajlm-988	70	7	length	length	NOUN
ajlm-988	70	8	polymorphism	polymorphism	NOUN
ajlm-988	70	9	for	for	ADP
ajlm-988	70	10	c.481c	c.481c	PROPN
ajlm-988	70	11	>	>	PROPN
ajlm-988	70	12	t	t	PROPN
ajlm-988	70	13	wildtype	wildtype	NOUN
ajlm-988	70	14	and	and	CCONJ
ajlm-988	70	15	heterozygous	heterozygous	ADJ
ajlm-988	70	16	variant	variant	NOUN
ajlm-988	70	17	,	,	PUNCT
ajlm-988	70	18	western	western	ADJ
ajlm-988	70	19	cape	cape	NOUN
ajlm-988	70	20	,	,	PUNCT
ajlm-988	70	21	south	south	PROPN
ajlm-988	70	22	africa	africa	PROPN
ajlm-988	70	23	,	,	PUNCT
ajlm-988	70	24	2013–2016	2013–2016	NUM
ajlm-988	70	25	.	.	PUNCT
ajlm-988	71	1	agarose	agarose	NOUN
ajlm-988	71	2	gel	gel	NOUN
ajlm-988	71	3	electrophoresis	electrophoresis	NOUN
ajlm-988	71	4	of	of	ADP
ajlm-988	71	5	nat2	nat2	NOUN
ajlm-988	71	6	pcr	pcr	NOUN
ajlm-988	71	7	products	product	NOUN
ajlm-988	71	8	digested	digest	VERB
ajlm-988	71	9	with	with	ADP
ajlm-988	71	10	kpn1	kpn1	PROPN
ajlm-988	71	11	restriction	restriction	NOUN
ajlm-988	71	12	enzyme	enzyme	NOUN
ajlm-988	71	13	.	.	PUNCT
ajlm-988	72	1	the	the	DET
ajlm-988	72	2	c.481c	c.481c	PROPN
ajlm-988	72	3	>	>	PROPN
ajlm-988	72	4	t	t	PROPN
ajlm-988	72	5	variant	variant	NOUN
ajlm-988	72	6	destroys	destroy	VERB
ajlm-988	72	7	a	a	DET
ajlm-988	72	8	kpn1	kpn1	PROPN
ajlm-988	72	9	recognition	recognition	NOUN
ajlm-988	72	10	site	site	NOUN
ajlm-988	72	11	.	.	PUNCT
ajlm-988	73	1	lanes	lane	NOUN
ajlm-988	73	2	1	1	NUM
ajlm-988	73	3	and	and	CCONJ
ajlm-988	73	4	6	6	NUM
ajlm-988	73	5	:	:	PUNCT
ajlm-988	73	6	dna	dna	NOUN
ajlm-988	73	7	ladder	ladder	NOUN
ajlm-988	73	8	(	(	PUNCT
ajlm-988	73	9	thermo	thermo	NOUN
ajlm-988	73	10	scientific	scientific	ADJ
ajlm-988	73	11	generuler	generuler	NOUN
ajlm-988	73	12	dna	dna	PROPN
ajlm-988	73	13	ladder	ladder	NOUN
ajlm-988	73	14	mix	mix	NOUN
ajlm-988	73	15	)	)	PUNCT
ajlm-988	73	16	with	with	ADP
ajlm-988	73	17	relevant	relevant	ADJ
ajlm-988	73	18	corresponding	corresponding	ADJ
ajlm-988	73	19	bp	bp	PROPN
ajlm-988	73	20	sizes	size	NOUN
ajlm-988	73	21	indicated	indicate	VERB
ajlm-988	73	22	.	.	PUNCT
ajlm-988	74	1	lane	lane	NOUN
ajlm-988	74	2	2	2	NUM
ajlm-988	74	3	:	:	PUNCT
ajlm-988	74	4	patient	patient	ADJ
ajlm-988	74	5	sample	sample	NOUN
ajlm-988	74	6	(	(	PUNCT
ajlm-988	74	7	no	no	PRON
ajlm-988	74	8	c.481c	c.481c	PROPN
ajlm-988	74	9	>	>	NOUN
ajlm-988	74	10	t	t	NOUN
ajlm-988	74	11	variation	variation	NOUN
ajlm-988	74	12	)	)	PUNCT
ajlm-988	74	13	.	.	PUNCT
ajlm-988	75	1	lane	lane	NOUN
ajlm-988	75	2	3	3	NUM
ajlm-988	75	3	:	:	SYM
ajlm-988	75	4	normal	normal	ADJ
ajlm-988	75	5	control	control	NOUN
ajlm-988	75	6	(	(	PUNCT
ajlm-988	75	7	no	no	PRON
ajlm-988	75	8	c.481c	c.481c	PROPN
ajlm-988	75	9	>	>	NOUN
ajlm-988	75	10	t	t	NOUN
ajlm-988	75	11	variation	variation	NOUN
ajlm-988	75	12	)	)	PUNCT
ajlm-988	75	13	.	.	PUNCT
ajlm-988	76	1	lane	lane	NOUN
ajlm-988	76	2	4	4	NUM
ajlm-988	76	3	:	:	PUNCT
ajlm-988	76	4	heterozygous	heterozygous	ADJ
ajlm-988	76	5	control	control	NOUN
ajlm-988	76	6	(	(	PUNCT
ajlm-988	76	7	c.481c	c.481c	PROPN
ajlm-988	76	8	>	>	X
ajlm-988	76	9	t	t	NOUN
ajlm-988	76	10	variation	variation	NOUN
ajlm-988	76	11	on	on	ADP
ajlm-988	76	12	one	one	NUM
ajlm-988	76	13	allele	allele	NOUN
ajlm-988	76	14	)	)	PUNCT
ajlm-988	76	15	.	.	PUNCT
ajlm-988	77	1	lane	lane	NOUN
ajlm-988	77	2	5	5	NUM
ajlm-988	77	3	:	:	PUNCT
ajlm-988	77	4	blank	blank	ADJ
ajlm-988	77	5	.	.	PUNCT
ajlm-988	78	1	the	the	DET
ajlm-988	78	2	arrow	arrow	NOUN
ajlm-988	78	3	demonstrates	demonstrate	VERB
ajlm-988	78	4	the	the	DET
ajlm-988	78	5	uncut	uncut	ADJ
ajlm-988	78	6	allele	allele	NOUN
ajlm-988	78	7	(	(	PUNCT
ajlm-988	78	8	1003	1003	NUM
ajlm-988	78	9	bp	bp	NOUN
ajlm-988	78	10	)	)	PUNCT
ajlm-988	78	11	containing	contain	VERB
ajlm-988	78	12	the	the	DET
ajlm-988	78	13	c.481c	c.481c	PROPN
ajlm-988	78	14	>	>	X
ajlm-988	78	15	t	t	PROPN
ajlm-988	78	16	single	single	ADJ
ajlm-988	78	17	nucleotide	nucleotide	ADJ
ajlm-988	78	18	variant	variant	NOUN
ajlm-988	78	19	.	.	PUNCT
ajlm-988	79	1	the	the	DET
ajlm-988	79	2	two	two	NUM
ajlm-988	79	3	bands	band	NOUN
ajlm-988	79	4	(	(	PUNCT
ajlm-988	79	5	553	553	NUM
ajlm-988	79	6	base	base	NOUN
ajlm-988	79	7	pairs	pair	NOUN
ajlm-988	79	8	and	and	CCONJ
ajlm-988	79	9	450	450	NUM
ajlm-988	79	10	base	base	NOUN
ajlm-988	79	11	pairs	pair	NOUN
ajlm-988	79	12	)	)	PUNCT
ajlm-988	79	13	below	below	ADP
ajlm-988	79	14	this	this	DET
ajlm-988	79	15	band	band	NOUN
ajlm-988	79	16	demonstrate	demonstrate	VERB
ajlm-988	79	17	the	the	DET
ajlm-988	79	18	normal	normal	ADJ
ajlm-988	79	19	(	(	PUNCT
ajlm-988	79	20	and	and	CCONJ
ajlm-988	79	21	therefore	therefore	ADV
ajlm-988	79	22	cut	cut	VERB
ajlm-988	79	23	)	)	PUNCT
ajlm-988	79	24	allele	allele	NOUN
ajlm-988	79	25	.	.	PUNCT
ajlm-988	80	1	the	the	DET
ajlm-988	80	2	restriction	restriction	NOUN
ajlm-988	80	3	site	site	NOUN
ajlm-988	80	4	on	on	ADP
ajlm-988	80	5	the	the	DET
ajlm-988	80	6	normal	normal	ADJ
ajlm-988	80	7	allele	allele	NOUN
ajlm-988	80	8	is	be	AUX
ajlm-988	80	9	recognised	recognise	VERB
ajlm-988	80	10	and	and	CCONJ
ajlm-988	80	11	therefore	therefore	ADV
ajlm-988	80	12	cut	cut	VERB
ajlm-988	80	13	into	into	ADP
ajlm-988	80	14	smaller	small	ADJ
ajlm-988	80	15	fragments	fragment	NOUN
ajlm-988	80	16	,	,	PUNCT
ajlm-988	80	17	while	while	SCONJ
ajlm-988	80	18	the	the	DET
ajlm-988	80	19	affected	affected	ADJ
ajlm-988	80	20	allele	allele	NOUN
ajlm-988	80	21	is	be	AUX
ajlm-988	80	22	not	not	PART
ajlm-988	80	23	digested	digest	VERB
ajlm-988	80	24	,	,	PUNCT
ajlm-988	80	25	lending	lend	VERB
ajlm-988	80	26	itself	itself	PRON
ajlm-988	80	27	to	to	AUX
ajlm-988	80	28	excision	excision	NOUN
ajlm-988	80	29	for	for	ADP
ajlm-988	80	30	single	single	ADJ
ajlm-988	80	31	allele	allele	NOUN
ajlm-988	80	32	sequencing	sequence	VERB
ajlm-988	80	33	.	.	PUNCT
ajlm-988	81	1	amplification	amplification	NOUN
ajlm-988	81	2	-	-	PUNCT
ajlm-988	81	3	refractory	refractory	NOUN
ajlm-988	81	4	mutation	mutation	NOUN
ajlm-988	81	5	system	system	NOUN
ajlm-988	81	6	polymerase	polymerase	NOUN
ajlm-988	81	7	chain	chain	NOUN
ajlm-988	81	8	reaction	reaction	NOUN
ajlm-988	81	9	amplification	amplification	NOUN
ajlm-988	81	10	-	-	PUNCT
ajlm-988	81	11	refractory	refractory	NOUN
ajlm-988	81	12	mutation	mutation	NOUN
ajlm-988	81	13	system	system	NOUN
ajlm-988	81	14	pcr	pcr	NOUN
ajlm-988	81	15	was	be	AUX
ajlm-988	81	16	performed	perform	VERB
ajlm-988	81	17	for	for	ADP
ajlm-988	81	18	the	the	DET
ajlm-988	81	19	remaining	remain	VERB
ajlm-988	81	20	cases	case	NOUN
ajlm-988	81	21	with	with	ADP
ajlm-988	81	22	ambiguous	ambiguous	ADJ
ajlm-988	81	23	haplotypes	haplotype	NOUN
ajlm-988	81	24	containing	contain	VERB
ajlm-988	81	25	heterozygous	heterozygous	ADJ
ajlm-988	81	26	c.282c	c.282c	PROPN
ajlm-988	81	27	>	>	PROPN
ajlm-988	81	28	t	t	PROPN
ajlm-988	81	29	snvs	snvs	NOUN
ajlm-988	81	30	(	(	PUNCT
ajlm-988	81	31	n	n	NOUN
ajlm-988	81	32	=	=	SYM
ajlm-988	81	33	42	42	NUM
ajlm-988	81	34	)	)	PUNCT
ajlm-988	81	35	.	.	PUNCT
ajlm-988	82	1	an	an	DET
ajlm-988	82	2	arms	arm	NOUN
ajlm-988	82	3	forward	forward	ADJ
ajlm-988	82	4	primer	primer	NOUN
ajlm-988	82	5	(	(	PUNCT
ajlm-988	82	6	5′ccacaatgttaggagggtatttttat3′	5′ccacaatgttaggagggtatttttat3′	NUM
ajlm-988	82	7	)	)	PUNCT
ajlm-988	82	8	was	be	AUX
ajlm-988	82	9	designed	design	VERB
ajlm-988	82	10	to	to	PART
ajlm-988	82	11	recognise	recognise	VERB
ajlm-988	82	12	and	and	CCONJ
ajlm-988	82	13	amplify	amplify	VERB
ajlm-988	82	14	only	only	ADV
ajlm-988	82	15	alleles	allele	NOUN
ajlm-988	82	16	containing	contain	VERB
ajlm-988	82	17	the	the	DET
ajlm-988	82	18	c.282	c.282	NOUN
ajlm-988	82	19	t	t	NOUN
ajlm-988	82	20	variant	variant	NOUN
ajlm-988	82	21	base	base	NOUN
ajlm-988	82	22	.	.	PUNCT
ajlm-988	83	1	polymerase	polymerase	NOUN
ajlm-988	83	2	chain	chain	NOUN
ajlm-988	83	3	reactions	reaction	NOUN
ajlm-988	83	4	were	be	AUX
ajlm-988	83	5	performed	perform	VERB
ajlm-988	83	6	as	as	ADP
ajlm-988	83	7	before	before	ADV
ajlm-988	83	8	,	,	PUNCT
ajlm-988	83	9	using	use	VERB
ajlm-988	83	10	the	the	DET
ajlm-988	83	11	same	same	ADJ
ajlm-988	83	12	reverse	reverse	NOUN
ajlm-988	83	13	primer	primer	NOUN
ajlm-988	83	14	,	,	PUNCT
ajlm-988	83	15	with	with	ADP
ajlm-988	83	16	the	the	DET
ajlm-988	83	17	exception	exception	NOUN
ajlm-988	83	18	of	of	ADP
ajlm-988	83	19	an	an	DET
ajlm-988	83	20	annealing	anneal	VERB
ajlm-988	83	21	temperature	temperature	NOUN
ajlm-988	83	22	of	of	ADP
ajlm-988	83	23	62	62	NUM
ajlm-988	83	24	°	°	NOUN
ajlm-988	83	25	c	c	NOUN
ajlm-988	83	26	.	.	PUNCT
ajlm-988	84	1	after	after	ADP
ajlm-988	84	2	checking	check	VERB
ajlm-988	84	3	the	the	DET
ajlm-988	84	4	reaction	reaction	NOUN
ajlm-988	84	5	efficacy	efficacy	NOUN
ajlm-988	84	6	with	with	ADP
ajlm-988	84	7	agarose	agarose	NOUN
ajlm-988	84	8	gel	gel	NOUN
ajlm-988	84	9	electrophoresis	electrophoresis	NOUN
ajlm-988	84	10	,	,	PUNCT
ajlm-988	84	11	the	the	DET
ajlm-988	84	12	individual	individual	ADJ
ajlm-988	84	13	alleles	allele	NOUN
ajlm-988	84	14	were	be	AUX
ajlm-988	84	15	sequenced	sequence	VERB
ajlm-988	84	16	as	as	ADP
ajlm-988	84	17	before	before	ADV
ajlm-988	84	18	.	.	PUNCT
ajlm-988	85	1	data	datum	NOUN
ajlm-988	85	2	analysis	analysis	NOUN
ajlm-988	85	3	sequence	sequence	NOUN
ajlm-988	85	4	data	datum	NOUN
ajlm-988	85	5	were	be	AUX
ajlm-988	85	6	aligned	align	VERB
ajlm-988	85	7	to	to	ADP
ajlm-988	85	8	published	publish	VERB
ajlm-988	85	9	reference	reference	NOUN
ajlm-988	85	10	sequences	sequence	NOUN
ajlm-988	85	11	using	use	VERB
ajlm-988	85	12	the	the	DET
ajlm-988	85	13	clustalw	clustalw	NOUN
ajlm-988	85	14	alignment	alignment	NOUN
ajlm-988	85	15	function	function	NOUN
ajlm-988	85	16	in	in	ADP
ajlm-988	85	17	bioedit	bioedit	NOUN
ajlm-988	85	18	version	version	NOUN
ajlm-988	85	19	7.2.528	7.2.528	NUM
ajlm-988	85	20	and	and	CCONJ
ajlm-988	85	21	analysed	analyse	VERB
ajlm-988	85	22	.	.	PUNCT
ajlm-988	86	1	the	the	DET
ajlm-988	86	2	court	court	NOUN
ajlm-988	86	3	lab	lab	NOUN
ajlm-988	86	4	online	online	ADJ
ajlm-988	86	5	calculator	calculator	NOUN
ajlm-988	86	6	was	be	AUX
ajlm-988	86	7	used	use	VERB
ajlm-988	86	8	to	to	PART
ajlm-988	86	9	assess	assess	VERB
ajlm-988	86	10	whether	whether	SCONJ
ajlm-988	86	11	the	the	DET
ajlm-988	86	12	variants	variant	NOUN
ajlm-988	86	13	were	be	AUX
ajlm-988	86	14	in	in	ADP
ajlm-988	86	15	hardy	hardy	ADJ
ajlm-988	86	16	-	-	PUNCT
ajlm-988	86	17	weinberg	weinberg	NOUN
ajlm-988	86	18	equilibrium,29	equilibrium,29	NOUN
ajlm-988	86	19	and	and	CCONJ
ajlm-988	86	20	haplotypes	haplotype	NOUN
ajlm-988	86	21	were	be	AUX
ajlm-988	86	22	assigned	assign	VERB
ajlm-988	86	23	by	by	ADP
ajlm-988	86	24	molecular	molecular	ADJ
ajlm-988	86	25	methods	method	NOUN
ajlm-988	86	26	.	.	PUNCT
ajlm-988	87	1	phase	phase	NOUN
ajlm-988	87	2	computational	computational	ADJ
ajlm-988	87	3	algorithm	algorithm	NOUN
ajlm-988	87	4	results	result	NOUN
ajlm-988	87	5	obtained	obtain	VERB
ajlm-988	87	6	from	from	ADP
ajlm-988	87	7	genotyping	genotyping	NOUN
ajlm-988	87	8	of	of	ADP
ajlm-988	87	9	both	both	CCONJ
ajlm-988	87	10	ambiguous	ambiguous	ADJ
ajlm-988	87	11	(	(	PUNCT
ajlm-988	87	12	n	n	NOUN
ajlm-988	87	13	=	=	SYM
ajlm-988	87	14	67	67	NUM
ajlm-988	87	15	)	)	PUNCT
ajlm-988	87	16	and	and	CCONJ
ajlm-988	87	17	non	non	ADJ
ajlm-988	87	18	-	-	ADJ
ajlm-988	87	19	ambiguous	ambiguous	ADJ
ajlm-988	87	20	samples	sample	NOUN
ajlm-988	87	21	(	(	PUNCT
ajlm-988	87	22	n	n	NOUN
ajlm-988	87	23	=	=	SYM
ajlm-988	87	24	26	26	NUM
ajlm-988	87	25	)	)	PUNCT
ajlm-988	87	26	were	be	AUX
ajlm-988	87	27	used	use	VERB
ajlm-988	87	28	as	as	ADP
ajlm-988	87	29	input	input	NOUN
ajlm-988	87	30	data	datum	NOUN
ajlm-988	87	31	for	for	ADP
ajlm-988	87	32	the	the	DET
ajlm-988	87	33	phase	phase	NOUN
ajlm-988	87	34	computational	computational	ADJ
ajlm-988	87	35	algorithm.21,22	algorithm.21,22	NOUN
ajlm-988	87	36	the	the	DET
ajlm-988	87	37	following	follow	VERB
ajlm-988	87	38	data	datum	NOUN
ajlm-988	87	39	were	be	AUX
ajlm-988	87	40	inputted	inputte	VERB
ajlm-988	87	41	:	:	PUNCT
ajlm-988	87	42	number	number	NOUN
ajlm-988	87	43	of	of	ADP
ajlm-988	87	44	variant	variant	ADJ
ajlm-988	87	45	positions	position	NOUN
ajlm-988	87	46	,	,	PUNCT
ajlm-988	87	47	variant	variant	ADJ
ajlm-988	87	48	nucleotide	nucleotide	NOUN
ajlm-988	87	49	positions	position	NOUN
ajlm-988	87	50	and	and	CCONJ
ajlm-988	87	51	the	the	DET
ajlm-988	87	52	genotypes	genotype	NOUN
ajlm-988	87	53	for	for	ADP
ajlm-988	87	54	each	each	DET
ajlm-988	87	55	sample	sample	NOUN
ajlm-988	87	56	at	at	ADP
ajlm-988	87	57	those	those	DET
ajlm-988	87	58	positions	position	NOUN
ajlm-988	87	59	(	(	PUNCT
ajlm-988	87	60	wild	wild	ADJ
ajlm-988	87	61	type	type	NOUN
ajlm-988	87	62	,	,	PUNCT
ajlm-988	87	63	heterozygous	heterozygous	ADJ
ajlm-988	87	64	,	,	PUNCT
ajlm-988	87	65	homozygous	homozygous	ADJ
ajlm-988	87	66	)	)	PUNCT
ajlm-988	87	67	.	.	PUNCT
ajlm-988	88	1	the	the	DET
ajlm-988	88	2	following	follow	VERB
ajlm-988	88	3	parameters	parameter	NOUN
ajlm-988	88	4	were	be	AUX
ajlm-988	88	5	specified	specify	VERB
ajlm-988	88	6	:	:	PUNCT
ajlm-988	88	7	number	number	NOUN
ajlm-988	88	8	of	of	ADP
ajlm-988	88	9	iterations	iteration	NOUN
ajlm-988	88	10	(=	(=	NOUN
ajlm-988	88	11	1000	1000	NUM
ajlm-988	88	12	)	)	PUNCT
ajlm-988	88	13	,	,	PUNCT
ajlm-988	88	14	thinning	thin	VERB
ajlm-988	88	15	interval	interval	NOUN
ajlm-988	88	16	(=	(=	NOUN
ajlm-988	88	17	1	1	NUM
ajlm-988	88	18	)	)	PUNCT
ajlm-988	88	19	,	,	PUNCT
ajlm-988	88	20	burn	burn	VERB
ajlm-988	88	21	-	-	PUNCT
ajlm-988	88	22	in	in	ADP
ajlm-988	88	23	(=	(=	NOUN
ajlm-988	88	24	100	100	NUM
ajlm-988	88	25	)	)	PUNCT
ajlm-988	88	26	.	.	PUNCT
ajlm-988	89	1	statistical	statistical	ADJ
ajlm-988	89	2	analysis	analysis	NOUN
ajlm-988	89	3	the	the	DET
ajlm-988	89	4	information	information	NOUN
ajlm-988	89	5	obtained	obtain	VERB
ajlm-988	89	6	by	by	ADP
ajlm-988	89	7	molecular	molecular	ADJ
ajlm-988	89	8	and	and	CCONJ
ajlm-988	89	9	computational	computational	ADJ
ajlm-988	89	10	haplotyping	haplotyping	NOUN
ajlm-988	89	11	was	be	AUX
ajlm-988	89	12	compared	compare	VERB
ajlm-988	89	13	by	by	ADP
ajlm-988	89	14	kappa	kappa	PROPN
ajlm-988	89	15	statistics	statistic	NOUN
ajlm-988	89	16	using	use	VERB
ajlm-988	89	17	stata	stata	NOUN
ajlm-988	89	18	13	13	NUM
ajlm-988	89	19	(	(	PUNCT
ajlm-988	89	20	statacorp	statacorp	PROPN
ajlm-988	89	21	llc	llc	PROPN
ajlm-988	89	22	,	,	PUNCT
ajlm-988	89	23	college	college	NOUN
ajlm-988	89	24	station	station	NOUN
ajlm-988	89	25	,	,	PUNCT
ajlm-988	89	26	texas	texas	PROPN
ajlm-988	89	27	,	,	PUNCT
ajlm-988	89	28	united	united	PROPN
ajlm-988	89	29	states	states	PROPN
ajlm-988	89	30	)	)	PUNCT
ajlm-988	89	31	.	.	PUNCT
ajlm-988	90	1	the	the	DET
ajlm-988	90	2	p	p	NOUN
ajlm-988	90	3	-	-	PUNCT
ajlm-988	90	4	values	value	NOUN
ajlm-988	90	5	less	less	ADJ
ajlm-988	90	6	than	than	ADP
ajlm-988	90	7	0.05	0.05	NUM
ajlm-988	90	8	were	be	AUX
ajlm-988	90	9	considered	consider	VERB
ajlm-988	90	10	statistically	statistically	ADV
ajlm-988	90	11	significant	significant	ADJ
ajlm-988	90	12	.	.	PUNCT
ajlm-988	91	1	results	result	NOUN
ajlm-988	91	2	genotypes	genotype	NOUN
ajlm-988	91	3	from	from	ADP
ajlm-988	91	4	all	all	DET
ajlm-988	91	5	100	100	NUM
ajlm-988	91	6	samples	sample	NOUN
ajlm-988	91	7	were	be	AUX
ajlm-988	91	8	found	find	VERB
ajlm-988	91	9	to	to	PART
ajlm-988	91	10	be	be	AUX
ajlm-988	91	11	in	in	ADP
ajlm-988	91	12	hardy	hardy	ADJ
ajlm-988	91	13	-	-	PUNCT
ajlm-988	91	14	weinberg	weinberg	NOUN
ajlm-988	91	15	equilibrium	equilibrium	NOUN
ajlm-988	91	16	for	for	ADP
ajlm-988	91	17	each	each	DET
ajlm-988	91	18	snv	snv	NOUN
ajlm-988	91	19	detected	detect	VERB
ajlm-988	91	20	in	in	ADP
ajlm-988	91	21	the	the	DET
ajlm-988	91	22	study	study	NOUN
ajlm-988	91	23	population	population	NOUN
ajlm-988	91	24	(	(	PUNCT
ajlm-988	91	25	table	table	NOUN
ajlm-988	91	26	1	1	NUM
ajlm-988	91	27	)	)	PUNCT
ajlm-988	91	28	.	.	PUNCT
ajlm-988	92	1	four	four	NUM
ajlm-988	92	2	samples	sample	NOUN
ajlm-988	92	3	were	be	AUX
ajlm-988	92	4	heterozygous	heterozygous	ADJ
ajlm-988	92	5	for	for	ADP
ajlm-988	92	6	both	both	PRON
ajlm-988	92	7	c.590g	c.590g	PROPN
ajlm-988	92	8	>	>	X
ajlm-988	92	9	a	a	DET
ajlm-988	92	10	and	and	CCONJ
ajlm-988	92	11	c.857g	c.857g	NOUN
ajlm-988	92	12	>	>	X
ajlm-988	92	13	a	a	PRON
ajlm-988	92	14	,	,	PUNCT
ajlm-988	92	15	while	while	SCONJ
ajlm-988	92	16	another	another	DET
ajlm-988	92	17	one	one	NOUN
ajlm-988	92	18	was	be	AUX
ajlm-988	92	19	heterozygous	heterozygous	ADJ
ajlm-988	92	20	for	for	ADP
ajlm-988	92	21	both	both	DET
ajlm-988	92	22	c.341t	c.341t	PROPN
ajlm-988	92	23	>	>	X
ajlm-988	92	24	c	c	PROPN
ajlm-988	92	25	and	and	CCONJ
ajlm-988	92	26	c.803a	c.803a	PROPN
ajlm-988	92	27	>	>	X
ajlm-988	92	28	g.	g.	PROPN
ajlm-988	93	1	no	no	DET
ajlm-988	93	2	further	further	ADJ
ajlm-988	93	3	work	work	NOUN
ajlm-988	93	4	was	be	AUX
ajlm-988	93	5	done	do	VERB
ajlm-988	93	6	on	on	ADP
ajlm-988	93	7	these	these	PRON
ajlm-988	93	8	,	,	PUNCT
ajlm-988	93	9	although	although	SCONJ
ajlm-988	93	10	future	future	ADJ
ajlm-988	93	11	studies	study	NOUN
ajlm-988	93	12	should	should	AUX
ajlm-988	93	13	aim	aim	VERB
ajlm-988	93	14	to	to	PART
ajlm-988	93	15	analyse	analyse	VERB
ajlm-988	93	16	these	these	PRON
ajlm-988	93	17	with	with	ADP
ajlm-988	93	18	similar	similar	ADJ
ajlm-988	93	19	arms	arm	NOUN
ajlm-988	93	20	or	or	CCONJ
ajlm-988	93	21	rflp	rflp	NOUN
ajlm-988	93	22	techniques	technique	NOUN
ajlm-988	93	23	and	and	CCONJ
ajlm-988	93	24	those	those	PRON
ajlm-988	93	25	employed	employ	VERB
ajlm-988	93	26	here	here	ADV
ajlm-988	93	27	.	.	PUNCT
ajlm-988	94	1	an	an	DET
ajlm-988	94	2	additional	additional	ADJ
ajlm-988	94	3	two	two	NUM
ajlm-988	94	4	ambiguous	ambiguous	ADJ
ajlm-988	94	5	samples	sample	NOUN
ajlm-988	94	6	could	could	AUX
ajlm-988	94	7	not	not	PART
ajlm-988	94	8	be	be	AUX
ajlm-988	94	9	assigned	assign	VERB
ajlm-988	94	10	haplotypes	haplotype	NOUN
ajlm-988	94	11	due	due	ADJ
ajlm-988	94	12	to	to	ADP
ajlm-988	94	13	degraded	degraded	ADJ
ajlm-988	94	14	dna	dna	NOUN
ajlm-988	94	15	and	and	CCONJ
ajlm-988	94	16	repeatedly	repeatedly	ADV
ajlm-988	94	17	failed	fail	VERB
ajlm-988	94	18	amplification	amplification	NOUN
ajlm-988	95	1	–	–	PUNCT
ajlm-988	95	2	a	a	DET
ajlm-988	95	3	total	total	NOUN
ajlm-988	95	4	of	of	ADP
ajlm-988	95	5	seven	seven	NUM
ajlm-988	95	6	samples	sample	NOUN
ajlm-988	95	7	were	be	AUX
ajlm-988	95	8	thus	thus	ADV
ajlm-988	95	9	excluded	exclude	VERB
ajlm-988	95	10	from	from	ADP
ajlm-988	95	11	further	further	ADJ
ajlm-988	95	12	analysis	analysis	NOUN
ajlm-988	95	13	.	.	PUNCT
ajlm-988	96	1	table	table	NOUN
ajlm-988	96	2	1	1	NUM
ajlm-988	96	3	:	:	PUNCT
ajlm-988	96	4	 	 	SPACE
ajlm-988	96	5	frequencies	frequency	NOUN
ajlm-988	96	6	of	of	ADP
ajlm-988	96	7	heterozygotes	heterozygote	NOUN
ajlm-988	96	8	and	and	CCONJ
ajlm-988	96	9	homozygotes	homozygote	NOUN
ajlm-988	96	10	for	for	ADP
ajlm-988	96	11	each	each	DET
ajlm-988	96	12	observed	observe	VERB
ajlm-988	96	13	single	single	ADJ
ajlm-988	96	14	nucleotide	nucleotide	ADJ
ajlm-988	96	15	variant	variant	NOUN
ajlm-988	96	16	,	,	PUNCT
ajlm-988	96	17	with	with	ADP
ajlm-988	96	18	associated	associated	ADJ
ajlm-988	96	19	hardy	hardy	ADJ
ajlm-988	96	20	-	-	PUNCT
ajlm-988	96	21	weinberg	weinberg	NOUN
ajlm-988	96	22	equilibrium	equilibrium	NOUN
ajlm-988	96	23	probabilities	probability	NOUN
ajlm-988	96	24	,	,	PUNCT
ajlm-988	96	25	western	western	ADJ
ajlm-988	96	26	cape	cape	NOUN
ajlm-988	96	27	,	,	PUNCT
ajlm-988	96	28	south	south	PROPN
ajlm-988	96	29	africa	africa	PROPN
ajlm-988	96	30	,	,	PUNCT
ajlm-988	96	31	2013–2016	2013–2016	NUM
ajlm-988	96	32	.	.	PUNCT
ajlm-988	97	1	of	of	ADP
ajlm-988	97	2	the	the	DET
ajlm-988	97	3	93	93	NUM
ajlm-988	97	4	remaining	remain	VERB
ajlm-988	97	5	samples	sample	NOUN
ajlm-988	97	6	,	,	PUNCT
ajlm-988	97	7	26	26	NUM
ajlm-988	97	8	were	be	AUX
ajlm-988	97	9	non	non	ADJ
ajlm-988	97	10	-	-	ADJ
ajlm-988	97	11	ambiguous	ambiguous	ADJ
ajlm-988	97	12	genotypes	genotype	NOUN
ajlm-988	97	13	and	and	CCONJ
ajlm-988	97	14	therefore	therefore	ADV
ajlm-988	97	15	did	do	AUX
ajlm-988	97	16	not	not	PART
ajlm-988	97	17	require	require	VERB
ajlm-988	97	18	haplotyping	haplotyping	ADJ
ajlm-988	97	19	.	.	PUNCT
ajlm-988	98	1	these	these	DET
ajlm-988	98	2	26	26	NUM
ajlm-988	98	3	genotypes	genotype	NOUN
ajlm-988	98	4	comprised	comprise	VERB
ajlm-988	98	5	either	either	CCONJ
ajlm-988	98	6	only	only	ADV
ajlm-988	98	7	wild	wild	ADJ
ajlm-988	98	8	type	type	NOUN
ajlm-988	98	9	variants	variant	NOUN
ajlm-988	98	10	(	(	PUNCT
ajlm-988	98	11	n	n	NOUN
ajlm-988	98	12	=	=	SYM
ajlm-988	98	13	6	6	NUM
ajlm-988	98	14	)	)	PUNCT
ajlm-988	98	15	,	,	PUNCT
ajlm-988	98	16	or	or	CCONJ
ajlm-988	98	17	were	be	AUX
ajlm-988	98	18	homozygous	homozygous	ADJ
ajlm-988	98	19	for	for	ADP
ajlm-988	98	20	any	any	DET
ajlm-988	98	21	particular	particular	ADJ
ajlm-988	98	22	haplotype	haplotype	NOUN
ajlm-988	98	23	(	(	PUNCT
ajlm-988	98	24	n	n	NOUN
ajlm-988	98	25	=	=	NUM
ajlm-988	98	26	20	20	NUM
ajlm-988	98	27	)	)	PUNCT
ajlm-988	98	28	.	.	PUNCT
ajlm-988	99	1	separation	separation	NOUN
ajlm-988	99	2	of	of	ADP
ajlm-988	99	3	the	the	DET
ajlm-988	99	4	non	non	ADJ
ajlm-988	99	5	-	-	ADJ
ajlm-988	99	6	ambiguous	ambiguous	ADJ
ajlm-988	99	7	alleles	allele	NOUN
ajlm-988	99	8	by	by	ADP
ajlm-988	99	9	rflp	rflp	PROPN
ajlm-988	99	10	or	or	CCONJ
ajlm-988	99	11	arms	arm	NOUN
ajlm-988	99	12	pcr	pcr	NOUN
ajlm-988	99	13	was	be	AUX
ajlm-988	99	14	thus	thus	ADV
ajlm-988	99	15	not	not	PART
ajlm-988	99	16	necessary	necessary	ADJ
ajlm-988	99	17	and	and	CCONJ
ajlm-988	99	18	haplotypes	haplotype	NOUN
ajlm-988	99	19	could	could	AUX
ajlm-988	99	20	be	be	AUX
ajlm-988	99	21	assigned	assign	VERB
ajlm-988	99	22	directly	directly	ADV
ajlm-988	99	23	to	to	ADP
ajlm-988	99	24	these	these	DET
ajlm-988	99	25	samples	sample	NOUN
ajlm-988	99	26	.	.	PUNCT
ajlm-988	100	1	allele	allele	NOUN
ajlm-988	100	2	separation	separation	NOUN
ajlm-988	100	3	and	and	CCONJ
ajlm-988	100	4	haplotype	haplotype	ADJ
ajlm-988	100	5	determination	determination	NOUN
ajlm-988	100	6	for	for	ADP
ajlm-988	100	7	the	the	DET
ajlm-988	100	8	remaining	remain	VERB
ajlm-988	100	9	67	67	NUM
ajlm-988	100	10	samples	sample	NOUN
ajlm-988	100	11	were	be	AUX
ajlm-988	100	12	obtained	obtain	VERB
ajlm-988	100	13	using	use	VERB
ajlm-988	100	14	the	the	DET
ajlm-988	100	15	rflp	rflp	NOUN
ajlm-988	100	16	and	and	CCONJ
ajlm-988	100	17	arms	arm	NOUN
ajlm-988	100	18	methods	method	NOUN
ajlm-988	100	19	described	describe	VERB
ajlm-988	100	20	earlier	early	ADV
ajlm-988	100	21	.	.	PUNCT
ajlm-988	101	1	the	the	DET
ajlm-988	101	2	non	non	ADJ
ajlm-988	101	3	-	-	ADJ
ajlm-988	101	4	ambiguous	ambiguous	ADJ
ajlm-988	101	5	samples	sample	NOUN
ajlm-988	101	6	demonstrated	demonstrate	VERB
ajlm-988	101	7	a	a	DET
ajlm-988	101	8	predominance	predominance	NOUN
ajlm-988	101	9	of	of	ADP
ajlm-988	101	10	haplotype	haplotype	NOUN
ajlm-988	101	11	nat2	nat2	NOUN
ajlm-988	101	12	*	*	PUNCT
ajlm-988	101	13	5b	5b	NUM
ajlm-988	101	14	(	(	PUNCT
ajlm-988	101	15	28	28	NUM
ajlm-988	101	16	%	%	NOUN
ajlm-988	101	17	)	)	PUNCT
ajlm-988	101	18	,	,	PUNCT
ajlm-988	101	19	followed	follow	VERB
ajlm-988	101	20	by	by	ADP
ajlm-988	101	21	nat2	nat2	PROPN
ajlm-988	101	22	*	*	SYM
ajlm-988	101	23	4	4	NUM
ajlm-988	101	24	(	(	PUNCT
ajlm-988	101	25	25	25	NUM
ajlm-988	101	26	%	%	NOUN
ajlm-988	101	27	)	)	PUNCT
ajlm-988	101	28	,	,	PUNCT
ajlm-988	101	29	nat2	nat2	PROPN
ajlm-988	101	30	*	*	NOUN
ajlm-988	101	31	6a	6a	NOUN
ajlm-988	101	32	(	(	PUNCT
ajlm-988	101	33	17	17	NUM
ajlm-988	101	34	%	%	NOUN
ajlm-988	101	35	)	)	PUNCT
ajlm-988	101	36	,	,	PUNCT
ajlm-988	101	37	nat2	nat2	PROPN
ajlm-988	101	38	*	*	NOUN
ajlm-988	101	39	12a	12a	NUM
ajlm-988	101	40	(	(	PUNCT
ajlm-988	101	41	12	12	NUM
ajlm-988	101	42	%	%	NOUN
ajlm-988	101	43	)	)	PUNCT
ajlm-988	101	44	,	,	PUNCT
ajlm-988	101	45	nat2	nat2	PROPN
ajlm-988	101	46	*	*	SYM
ajlm-988	101	47	13a	13a	PROPN
ajlm-988	101	48	and	and	CCONJ
ajlm-988	101	49	nat2	nat2	PROPN
ajlm-988	101	50	*	*	PUNCT
ajlm-988	101	51	5c	5c	NUM
ajlm-988	101	52	(	(	PUNCT
ajlm-988	101	53	both	both	PRON
ajlm-988	101	54	6	6	NUM
ajlm-988	101	55	%	%	NOUN
ajlm-988	101	56	)	)	PUNCT
ajlm-988	101	57	,	,	PUNCT
ajlm-988	101	58	nat2	nat2	PROPN
ajlm-988	101	59	*	*	PROPN
ajlm-988	101	60	5a	5a	NUM
ajlm-988	101	61	(	(	PUNCT
ajlm-988	101	62	4	4	NUM
ajlm-988	101	63	%	%	NOUN
ajlm-988	101	64	)	)	PUNCT
ajlm-988	101	65	and	and	CCONJ
ajlm-988	101	66	nat2	nat2	PROPN
ajlm-988	101	67	*	*	NUM
ajlm-988	101	68	27	27	NUM
ajlm-988	101	69	(	(	PUNCT
ajlm-988	101	70	2	2	NUM
ajlm-988	101	71	%	%	NOUN
ajlm-988	101	72	)	)	PUNCT
ajlm-988	101	73	.	.	PUNCT
ajlm-988	102	1	apart	apart	ADV
ajlm-988	102	2	from	from	ADP
ajlm-988	102	3	the	the	DET
ajlm-988	102	4	commonly	commonly	ADV
ajlm-988	102	5	described	describe	VERB
ajlm-988	102	6	nat2	nat2	NOUN
ajlm-988	102	7	snvs	snvs	NOUN
ajlm-988	102	8	,	,	PUNCT
ajlm-988	102	9	four	four	NUM
ajlm-988	102	10	additional	additional	ADJ
ajlm-988	102	11	variants	variant	NOUN
ajlm-988	102	12	were	be	AUX
ajlm-988	102	13	detected	detect	VERB
ajlm-988	102	14	in	in	ADP
ajlm-988	102	15	our	our	PRON
ajlm-988	102	16	study	study	NOUN
ajlm-988	102	17	population	population	NOUN
ajlm-988	102	18	.	.	PUNCT
ajlm-988	103	1	a	a	DET
ajlm-988	103	2	single	single	ADJ
ajlm-988	103	3	sample	sample	NOUN
ajlm-988	103	4	was	be	AUX
ajlm-988	103	5	heterozygous	heterozygous	ADJ
ajlm-988	103	6	for	for	ADP
ajlm-988	103	7	the	the	DET
ajlm-988	103	8	c.622t	c.622t	PROPN
ajlm-988	103	9	>	>	X
ajlm-988	103	10	c	c	X
ajlm-988	103	11	(	(	PUNCT
ajlm-988	103	12	p.tyr208his	p.tyr208his	NOUN
ajlm-988	103	13	)	)	PUNCT
ajlm-988	103	14	variant	variant	NOUN
ajlm-988	103	15	(	(	PUNCT
ajlm-988	103	16	rs56387565	rs56387565	NOUN
ajlm-988	103	17	)	)	PUNCT
ajlm-988	103	18	.	.	PUNCT
ajlm-988	104	1	in	in	ADP
ajlm-988	104	2	this	this	DET
ajlm-988	104	3	instance	instance	NOUN
ajlm-988	104	4	,	,	PUNCT
ajlm-988	104	5	it	it	PRON
ajlm-988	104	6	co	co	VERB
ajlm-988	104	7	-	-	VERB
ajlm-988	104	8	occurred	occur	VERB
ajlm-988	104	9	with	with	ADP
ajlm-988	104	10	c.803a	c.803a	PROPN
ajlm-988	104	11	>	>	NOUN
ajlm-988	104	12	g	g	PROPN
ajlm-988	104	13	,	,	PUNCT
ajlm-988	104	14	resulting	result	VERB
ajlm-988	104	15	in	in	ADP
ajlm-988	104	16	the	the	DET
ajlm-988	104	17	less	less	ADV
ajlm-988	104	18	common	common	ADJ
ajlm-988	104	19	haplotype	haplotype	NOUN
ajlm-988	104	20	nat2	nat2	NOUN
ajlm-988	104	21	*	*	X
ajlm-988	104	22	12f	12f	NUM
ajlm-988	104	23	.	.	PUNCT
ajlm-988	105	1	another	another	PRON
ajlm-988	105	2	was	be	AUX
ajlm-988	105	3	heterozygous	heterozygous	ADJ
ajlm-988	105	4	for	for	ADP
ajlm-988	105	5	c.809t	c.809t	PROPN
ajlm-988	105	6	>	>	PROPN
ajlm-988	105	7	c	c	PROPN
ajlm-988	105	8	(	(	PUNCT
ajlm-988	105	9	p.ile270thr	p.ile270thr	PROPN
ajlm-988	105	10	)	)	PUNCT
ajlm-988	105	11	(	(	PUNCT
ajlm-988	105	12	rs868725509	rs868725509	NOUN
ajlm-988	105	13	)	)	PUNCT
ajlm-988	105	14	.	.	PUNCT
ajlm-988	106	1	it	it	PRON
ajlm-988	106	2	co	co	VERB
ajlm-988	106	3	-	-	VERB
ajlm-988	106	4	occurred	occur	VERB
ajlm-988	106	5	with	with	ADP
ajlm-988	106	6	c.341t	c.341t	PROPN
ajlm-988	106	7	>	>	NOUN
ajlm-988	106	8	c	c	PROPN
ajlm-988	106	9	and	and	CCONJ
ajlm-988	106	10	c.803a	c.803a	PROPN
ajlm-988	106	11	>	>	NOUN
ajlm-988	106	12	g	g	PROPN
ajlm-988	106	13	;	;	PUNCT
ajlm-988	106	14	molecular	molecular	ADJ
ajlm-988	106	15	haplotyping	haplotyping	NOUN
ajlm-988	106	16	could	could	AUX
ajlm-988	106	17	not	not	PART
ajlm-988	106	18	be	be	AUX
ajlm-988	106	19	performed	perform	VERB
ajlm-988	106	20	on	on	ADP
ajlm-988	106	21	this	this	DET
ajlm-988	106	22	ambiguous	ambiguous	ADJ
ajlm-988	106	23	sample	sample	NOUN
ajlm-988	106	24	due	due	ADP
ajlm-988	106	25	to	to	ADP
ajlm-988	106	26	the	the	DET
ajlm-988	106	27	inability	inability	NOUN
ajlm-988	106	28	to	to	PART
ajlm-988	106	29	delineate	delineate	VERB
ajlm-988	106	30	with	with	ADP
ajlm-988	106	31	available	available	ADJ
ajlm-988	106	32	methodology	methodology	NOUN
ajlm-988	106	33	.	.	PUNCT
ajlm-988	107	1	a	a	DET
ajlm-988	107	2	single	single	ADJ
ajlm-988	107	3	nonsense	nonsense	NOUN
ajlm-988	107	4	variant	variant	NOUN
ajlm-988	107	5	,	,	PUNCT
ajlm-988	107	6	c.589c	c.589c	PROPN
ajlm-988	107	7	>	>	X
ajlm-988	107	8	t	t	PROPN
ajlm-988	107	9	(	(	PUNCT
ajlm-988	107	10	p.arg197	p.arg197	NOUN
ajlm-988	107	11	*	*	PUNCT
ajlm-988	107	12	)	)	PUNCT
ajlm-988	107	13	,	,	PUNCT
ajlm-988	107	14	resulting	result	VERB
ajlm-988	107	15	in	in	ADP
ajlm-988	107	16	a	a	DET
ajlm-988	107	17	stop	stop	NOUN
ajlm-988	107	18	codon	codon	NOUN
ajlm-988	107	19	,	,	PUNCT
ajlm-988	107	20	was	be	AUX
ajlm-988	107	21	detected	detect	VERB
ajlm-988	107	22	in	in	ADP
ajlm-988	107	23	isolation	isolation	NOUN
ajlm-988	107	24	in	in	ADP
ajlm-988	107	25	one	one	NUM
ajlm-988	107	26	patient.30	patient.30	NOUN
ajlm-988	107	27	two	two	NUM
ajlm-988	107	28	samples	sample	NOUN
ajlm-988	107	29	were	be	AUX
ajlm-988	107	30	heterozygous	heterozygous	ADJ
ajlm-988	107	31	for	for	ADP
ajlm-988	107	32	a	a	DET
ajlm-988	107	33	very	very	ADV
ajlm-988	107	34	rare	rare	ADJ
ajlm-988	107	35	variant	variant	NOUN
ajlm-988	107	36	,	,	PUNCT
ajlm-988	107	37	c.387c	c.387c	PROPN
ajlm-988	107	38	>	>	X
ajlm-988	107	39	t	t	PROPN
ajlm-988	107	40	(	(	PUNCT
ajlm-988	107	41	p.ser129=	p.ser129=	PROPN
ajlm-988	107	42	)	)	PUNCT
ajlm-988	107	43	(	(	PUNCT
ajlm-988	107	44	rs144828000	rs144828000	PROPN
ajlm-988	107	45	)	)	PUNCT
ajlm-988	107	46	.	.	PUNCT
ajlm-988	108	1	in	in	ADP
ajlm-988	108	2	both	both	PRON
ajlm-988	108	3	of	of	ADP
ajlm-988	108	4	our	our	PRON
ajlm-988	108	5	patients	patient	NOUN
ajlm-988	108	6	,	,	PUNCT
ajlm-988	108	7	it	it	PRON
ajlm-988	108	8	co	co	VERB
ajlm-988	108	9	-	-	VERB
ajlm-988	108	10	occurred	occur	VERB
ajlm-988	108	11	with	with	ADP
ajlm-988	108	12	the	the	DET
ajlm-988	108	13	c.282c	c.282c	PROPN
ajlm-988	108	14	>	>	X
ajlm-988	108	15	t	t	PROPN
ajlm-988	108	16	and	and	CCONJ
ajlm-988	108	17	c.590g	c.590g	PROPN
ajlm-988	108	18	>	>	X
ajlm-988	108	19	a	a	DET
ajlm-988	108	20	variants	variant	NOUN
ajlm-988	108	21	(	(	PUNCT
ajlm-988	108	22	nat2	nat2	NOUN
ajlm-988	108	23	*	*	NOUN
ajlm-988	108	24	6a	6a	NOUN
ajlm-988	108	25	)	)	PUNCT
ajlm-988	108	26	.	.	PUNCT
ajlm-988	109	1	the	the	DET
ajlm-988	109	2	most	most	ADV
ajlm-988	109	3	common	common	ADJ
ajlm-988	109	4	haplotypes	haplotype	NOUN
ajlm-988	109	5	in	in	ADP
ajlm-988	109	6	the	the	DET
ajlm-988	109	7	67	67	NUM
ajlm-988	109	8	ambiguous	ambiguous	ADJ
ajlm-988	109	9	samples	sample	NOUN
ajlm-988	109	10	,	,	PUNCT
ajlm-988	109	11	derived	derive	VERB
ajlm-988	109	12	by	by	ADP
ajlm-988	109	13	molecular	molecular	ADJ
ajlm-988	109	14	methods	method	NOUN
ajlm-988	109	15	,	,	PUNCT
ajlm-988	109	16	were	be	AUX
ajlm-988	109	17	nat2	nat2	NOUN
ajlm-988	109	18	*	*	ADJ
ajlm-988	109	19	4	4	NUM
ajlm-988	109	20	(	(	PUNCT
ajlm-988	109	21	29.1	29.1	NUM
ajlm-988	109	22	%	%	NOUN
ajlm-988	109	23	)	)	PUNCT
ajlm-988	109	24	followed	follow	VERB
ajlm-988	109	25	by	by	ADP
ajlm-988	109	26	nat2	nat2	NOUN
ajlm-988	109	27	*	*	PUNCT
ajlm-988	109	28	5b	5b	NOUN
ajlm-988	109	29	(	(	PUNCT
ajlm-988	109	30	26.9	26.9	NUM
ajlm-988	109	31	%	%	NOUN
ajlm-988	109	32	)	)	PUNCT
ajlm-988	109	33	,	,	PUNCT
ajlm-988	109	34	nat2	nat2	PROPN
ajlm-988	109	35	*	*	NOUN
ajlm-988	109	36	6a	6a	NOUN
ajlm-988	109	37	(	(	PUNCT
ajlm-988	109	38	23.1	23.1	NUM
ajlm-988	109	39	%	%	NOUN
ajlm-988	109	40	)	)	PUNCT
ajlm-988	109	41	and	and	CCONJ
ajlm-988	109	42	nat2	nat2	PROPN
ajlm-988	109	43	*	*	NOUN
ajlm-988	109	44	12a	12a	NUM
ajlm-988	109	45	(	(	PUNCT
ajlm-988	109	46	6	6	NUM
ajlm-988	109	47	%	%	NOUN
ajlm-988	109	48	)	)	PUNCT
ajlm-988	109	49	.	.	PUNCT
ajlm-988	110	1	these	these	DET
ajlm-988	110	2	frequencies	frequency	NOUN
ajlm-988	110	3	were	be	AUX
ajlm-988	110	4	similarly	similarly	ADV
ajlm-988	110	5	predicted	predict	VERB
ajlm-988	110	6	by	by	ADP
ajlm-988	110	7	phase	phase	NOUN
ajlm-988	110	8	(	(	PUNCT
ajlm-988	110	9	table	table	NOUN
ajlm-988	110	10	2	2	NUM
ajlm-988	110	11	)	)	PUNCT
ajlm-988	110	12	.	.	PUNCT
ajlm-988	111	1	of	of	ADP
ajlm-988	111	2	67	67	NUM
ajlm-988	111	3	ambiguous	ambiguous	ADJ
ajlm-988	111	4	samples	sample	NOUN
ajlm-988	111	5	,	,	PUNCT
ajlm-988	111	6	15	15	NUM
ajlm-988	111	7	(	(	PUNCT
ajlm-988	111	8	22	22	NUM
ajlm-988	111	9	%	%	NOUN
ajlm-988	111	10	)	)	PUNCT
ajlm-988	111	11	required	require	VERB
ajlm-988	111	12	further	further	ADJ
ajlm-988	111	13	molecular	molecular	ADJ
ajlm-988	111	14	testing	testing	NOUN
ajlm-988	111	15	(	(	PUNCT
ajlm-988	111	16	i.e.	i.e.	X
ajlm-988	111	17	rflp	rflp	NOUN
ajlm-988	111	18	or	or	CCONJ
ajlm-988	111	19	arms	arm	NOUN
ajlm-988	111	20	pcr	pcr	NOUN
ajlm-988	111	21	)	)	PUNCT
ajlm-988	111	22	to	to	PART
ajlm-988	111	23	differentiate	differentiate	VERB
ajlm-988	111	24	between	between	ADP
ajlm-988	111	25	slow	slow	ADJ
ajlm-988	111	26	and	and	CCONJ
ajlm-988	111	27	intermediate	intermediate	ADJ
ajlm-988	111	28	acetylation	acetylation	NOUN
ajlm-988	111	29	phenotypes	phenotype	NOUN
ajlm-988	111	30	.	.	PUNCT
ajlm-988	112	1	in	in	ADP
ajlm-988	112	2	14	14	NUM
ajlm-988	112	3	(	(	PUNCT
ajlm-988	112	4	93	93	NUM
ajlm-988	112	5	%	%	NOUN
ajlm-988	112	6	)	)	PUNCT
ajlm-988	112	7	cases	case	NOUN
ajlm-988	112	8	,	,	PUNCT
ajlm-988	112	9	the	the	DET
ajlm-988	112	10	ambiguous	ambiguous	ADJ
ajlm-988	112	11	genotype	genotype	NOUN
ajlm-988	112	12	was	be	AUX
ajlm-988	112	13	resolved	resolve	VERB
ajlm-988	112	14	to	to	PART
ajlm-988	112	15	predict	predict	VERB
ajlm-988	112	16	a	a	DET
ajlm-988	112	17	slow	slow	ADJ
ajlm-988	112	18	acetylation	acetylation	NOUN
ajlm-988	112	19	phenotype	phenotype	NOUN
ajlm-988	112	20	.	.	PUNCT
ajlm-988	113	1	table	table	NOUN
ajlm-988	113	2	2	2	NUM
ajlm-988	113	3	:	:	PUNCT
ajlm-988	113	4	 	 	SPACE
ajlm-988	113	5	haplotype	haplotype	NOUN
ajlm-988	113	6	frequencies	frequency	NOUN
ajlm-988	113	7	as	as	SCONJ
ajlm-988	113	8	derived	derive	VERB
ajlm-988	113	9	by	by	ADP
ajlm-988	113	10	molecular	molecular	ADJ
ajlm-988	113	11	methods	method	NOUN
ajlm-988	113	12	,	,	PUNCT
ajlm-988	113	13	as	as	ADV
ajlm-988	113	14	well	well	ADV
ajlm-988	113	15	as	as	ADP
ajlm-988	113	16	predicted	predict	VERB
ajlm-988	113	17	by	by	ADP
ajlm-988	113	18	the	the	DET
ajlm-988	113	19	phase	phase	NOUN
ajlm-988	113	20	computational	computational	ADJ
ajlm-988	113	21	algorithm	algorithm	NOUN
ajlm-988	113	22	,	,	PUNCT
ajlm-988	113	23	western	western	ADJ
ajlm-988	113	24	cape	cape	NOUN
ajlm-988	113	25	,	,	PUNCT
ajlm-988	113	26	south	south	PROPN
ajlm-988	113	27	africa	africa	PROPN
ajlm-988	113	28	,	,	PUNCT
ajlm-988	113	29	2013–2016	2013–2016	NUM
ajlm-988	113	30	.	.	PUNCT
ajlm-988	114	1	there	there	PRON
ajlm-988	114	2	was	be	VERB
ajlm-988	114	3	a	a	DET
ajlm-988	114	4	94.6	94.6	NUM
ajlm-988	114	5	%	%	NOUN
ajlm-988	114	6	agreement	agreement	NOUN
ajlm-988	114	7	between	between	ADP
ajlm-988	114	8	the	the	DET
ajlm-988	114	9	haplotypes	haplotype	NOUN
ajlm-988	114	10	obtained	obtain	VERB
ajlm-988	114	11	by	by	ADP
ajlm-988	114	12	molecular	molecular	ADJ
ajlm-988	114	13	methods	method	NOUN
ajlm-988	114	14	and	and	CCONJ
ajlm-988	114	15	those	those	PRON
ajlm-988	114	16	predicted	predict	VERB
ajlm-988	114	17	by	by	ADP
ajlm-988	114	18	phase	phase	NOUN
ajlm-988	114	19	,	,	PUNCT
ajlm-988	114	20	with	with	ADP
ajlm-988	114	21	a	a	DET
ajlm-988	114	22	strong	strong	ADJ
ajlm-988	114	23	correlation	correlation	NOUN
ajlm-988	114	24	(	(	PUNCT
ajlm-988	114	25	kappa	kappa	NOUN
ajlm-988	114	26	0.94	0.94	NUM
ajlm-988	114	27	,	,	PUNCT
ajlm-988	114	28	p	p	X
ajlm-988	114	29	<	<	X
ajlm-988	114	30	0.001	0.001	NUM
ajlm-988	114	31	)	)	PUNCT
ajlm-988	114	32	.	.	PUNCT
ajlm-988	115	1	five	five	NUM
ajlm-988	115	2	haplotype	haplotype	NOUN
ajlm-988	115	3	combinations	combination	NOUN
ajlm-988	115	4	(	(	PUNCT
ajlm-988	115	5	from	from	ADP
ajlm-988	115	6	10	10	NUM
ajlm-988	115	7	chromosomes	chromosome	NOUN
ajlm-988	115	8	)	)	PUNCT
ajlm-988	115	9	were	be	AUX
ajlm-988	115	10	incorrectly	incorrectly	ADV
ajlm-988	115	11	predicted	predict	VERB
ajlm-988	115	12	.	.	PUNCT
ajlm-988	116	1	of	of	ADP
ajlm-988	116	2	these	these	PRON
ajlm-988	116	3	,	,	PUNCT
ajlm-988	116	4	only	only	ADV
ajlm-988	116	5	one	one	NUM
ajlm-988	116	6	resulted	result	VERB
ajlm-988	116	7	in	in	ADP
ajlm-988	116	8	a	a	DET
ajlm-988	116	9	change	change	NOUN
ajlm-988	116	10	of	of	ADP
ajlm-988	116	11	acetylation	acetylation	NOUN
ajlm-988	116	12	phenotype	phenotype	NOUN
ajlm-988	116	13	(	(	PUNCT
ajlm-988	116	14	intermediate	intermediate	ADJ
ajlm-988	116	15	to	to	PART
ajlm-988	116	16	slow	slow	VERB
ajlm-988	116	17	)	)	PUNCT
ajlm-988	116	18	.	.	PUNCT
ajlm-988	117	1	furthermore	furthermore	ADV
ajlm-988	117	2	,	,	PUNCT
ajlm-988	117	3	the	the	DET
ajlm-988	117	4	program	program	NOUN
ajlm-988	117	5	flagged	flag	VERB
ajlm-988	117	6	four	four	NUM
ajlm-988	117	7	of	of	ADP
ajlm-988	117	8	these	these	DET
ajlm-988	117	9	five	five	NUM
ajlm-988	117	10	incorrect	incorrect	ADJ
ajlm-988	117	11	haplotype	haplotype	NOUN
ajlm-988	117	12	combinations	combination	NOUN
ajlm-988	117	13	(	(	PUNCT
ajlm-988	117	14	including	include	VERB
ajlm-988	117	15	the	the	DET
ajlm-988	117	16	one	one	NOUN
ajlm-988	117	17	incorrectly	incorrectly	ADV
ajlm-988	117	18	assigned	assign	VERB
ajlm-988	117	19	to	to	PART
ajlm-988	117	20	slow	slow	VERB
ajlm-988	117	21	acetylator	acetylator	NOUN
ajlm-988	117	22	status	status	NOUN
ajlm-988	117	23	)	)	PUNCT
ajlm-988	117	24	to	to	PART
ajlm-988	117	25	indicate	indicate	VERB
ajlm-988	117	26	that	that	SCONJ
ajlm-988	117	27	uncertainty	uncertainty	NOUN
ajlm-988	117	28	was	be	AUX
ajlm-988	117	29	present	present	ADJ
ajlm-988	117	30	around	around	ADP
ajlm-988	117	31	one	one	NUM
ajlm-988	117	32	of	of	ADP
ajlm-988	117	33	the	the	DET
ajlm-988	117	34	predicted	predict	VERB
ajlm-988	117	35	variant	variant	NOUN
ajlm-988	117	36	positions	position	NOUN
ajlm-988	117	37	.	.	PUNCT
ajlm-988	118	1	discussion	discussion	NOUN
ajlm-988	118	2	nat2	nat2	NOUN
ajlm-988	118	3	genotypes	genotype	NOUN
ajlm-988	118	4	were	be	AUX
ajlm-988	118	5	obtained	obtain	VERB
ajlm-988	118	6	by	by	ADP
ajlm-988	118	7	molecular	molecular	ADJ
ajlm-988	118	8	methods	method	NOUN
ajlm-988	118	9	for	for	ADP
ajlm-988	118	10	100	100	NUM
ajlm-988	118	11	samples	sample	NOUN
ajlm-988	118	12	.	.	PUNCT
ajlm-988	119	1	ninety	ninety	NUM
ajlm-988	119	2	-	-	PUNCT
ajlm-988	119	3	three	three	NUM
ajlm-988	119	4	genotypes	genotype	NOUN
ajlm-988	119	5	were	be	AUX
ajlm-988	119	6	then	then	ADV
ajlm-988	119	7	used	use	VERB
ajlm-988	119	8	to	to	PART
ajlm-988	119	9	validate	validate	VERB
ajlm-988	119	10	the	the	DET
ajlm-988	119	11	accuracy	accuracy	NOUN
ajlm-988	119	12	of	of	ADP
ajlm-988	119	13	phase	phase	NOUN
ajlm-988	119	14	in	in	ADP
ajlm-988	119	15	predicting	predict	VERB
ajlm-988	119	16	haplotypes	haplotype	NOUN
ajlm-988	119	17	.	.	PUNCT
ajlm-988	120	1	twenty	twenty	NUM
ajlm-988	120	2	-	-	PUNCT
ajlm-988	120	3	six	six	NUM
ajlm-988	120	4	of	of	ADP
ajlm-988	120	5	these	these	DET
ajlm-988	120	6	samples	sample	NOUN
ajlm-988	120	7	had	have	VERB
ajlm-988	120	8	non	non	ADJ
ajlm-988	120	9	-	-	ADJ
ajlm-988	120	10	ambiguous	ambiguous	ADJ
ajlm-988	120	11	genotypes	genotype	NOUN
ajlm-988	120	12	;	;	PUNCT
ajlm-988	120	13	of	of	ADP
ajlm-988	120	14	the	the	DET
ajlm-988	120	15	remaining	remain	VERB
ajlm-988	120	16	67	67	NUM
ajlm-988	120	17	samples	sample	NOUN
ajlm-988	120	18	,	,	PUNCT
ajlm-988	120	19	only	only	ADV
ajlm-988	120	20	15	15	NUM
ajlm-988	120	21	(	(	PUNCT
ajlm-988	120	22	22.5	22.5	NUM
ajlm-988	120	23	%	%	NOUN
ajlm-988	120	24	)	)	PUNCT
ajlm-988	120	25	technically	technically	ADV
ajlm-988	120	26	needed	need	VERB
ajlm-988	120	27	further	further	ADJ
ajlm-988	120	28	allelic	allelic	ADJ
ajlm-988	120	29	haplotyping	haplotyping	NOUN
ajlm-988	120	30	,	,	PUNCT
ajlm-988	120	31	where	where	SCONJ
ajlm-988	120	32	the	the	DET
ajlm-988	120	33	ambiguous	ambiguous	ADJ
ajlm-988	120	34	genotype	genotype	NOUN
ajlm-988	120	35	could	could	AUX
ajlm-988	120	36	lead	lead	VERB
ajlm-988	120	37	to	to	ADP
ajlm-988	120	38	ambiguous	ambiguous	ADJ
ajlm-988	120	39	acetylation	acetylation	NOUN
ajlm-988	120	40	phenotype	phenotype	NOUN
ajlm-988	120	41	prediction	prediction	NOUN
ajlm-988	120	42	.	.	PUNCT
ajlm-988	121	1	this	this	PRON
ajlm-988	121	2	is	be	AUX
ajlm-988	121	3	in	in	ADP
ajlm-988	121	4	keeping	keep	VERB
ajlm-988	121	5	with	with	ADP
ajlm-988	121	6	possible	possible	ADJ
ajlm-988	121	7	clinical	clinical	ADJ
ajlm-988	121	8	scenarios	scenario	NOUN
ajlm-988	121	9	,	,	PUNCT
ajlm-988	121	10	where	where	SCONJ
ajlm-988	121	11	non	non	ADJ
ajlm-988	121	12	-	-	ADJ
ajlm-988	121	13	ambiguous	ambiguous	ADJ
ajlm-988	121	14	samples	sample	NOUN
ajlm-988	121	15	would	would	AUX
ajlm-988	121	16	not	not	PART
ajlm-988	121	17	in	in	ADP
ajlm-988	121	18	fact	fact	NOUN
ajlm-988	121	19	need	need	VERB
ajlm-988	121	20	to	to	PART
ajlm-988	121	21	be	be	AUX
ajlm-988	121	22	subjected	subject	VERB
ajlm-988	121	23	to	to	PART
ajlm-988	121	24	phase	phase	VERB
ajlm-988	121	25	analysis	analysis	NOUN
ajlm-988	121	26	to	to	PART
ajlm-988	121	27	obtain	obtain	VERB
ajlm-988	121	28	haplotypes	haplotype	NOUN
ajlm-988	121	29	.	.	PUNCT
ajlm-988	122	1	four	four	NUM
ajlm-988	122	2	rare	rare	ADJ
ajlm-988	122	3	snvs	snvs	NOUN
ajlm-988	122	4	were	be	AUX
ajlm-988	122	5	detected	detect	VERB
ajlm-988	122	6	in	in	ADP
ajlm-988	122	7	our	our	PRON
ajlm-988	122	8	study	study	NOUN
ajlm-988	122	9	population	population	NOUN
ajlm-988	122	10	.	.	PUNCT
ajlm-988	123	1	the	the	DET
ajlm-988	123	2	variant	variant	NOUN
ajlm-988	123	3	at	at	ADP
ajlm-988	123	4	position	position	NOUN
ajlm-988	123	5	c.622t	c.622t	PROPN
ajlm-988	123	6	>	>	X
ajlm-988	123	7	c	c	PROPN
ajlm-988	123	8	(	(	PUNCT
ajlm-988	123	9	rs56387565	rs56387565	NOUN
ajlm-988	123	10	)	)	PUNCT
ajlm-988	123	11	results	result	NOUN
ajlm-988	123	12	in	in	ADP
ajlm-988	123	13	a	a	DET
ajlm-988	123	14	non	non	ADJ
ajlm-988	123	15	-	-	ADJ
ajlm-988	123	16	synonymous	synonymous	ADJ
ajlm-988	123	17	change	change	NOUN
ajlm-988	123	18	(	(	PUNCT
ajlm-988	123	19	p.tyr208his	p.tyr208his	PROPN
ajlm-988	123	20	)	)	PUNCT
ajlm-988	123	21	;	;	PUNCT
ajlm-988	123	22	the	the	DET
ajlm-988	123	23	functional	functional	ADJ
ajlm-988	123	24	effect	effect	NOUN
ajlm-988	123	25	of	of	ADP
ajlm-988	123	26	this	this	DET
ajlm-988	123	27	variant	variant	NOUN
ajlm-988	123	28	is	be	AUX
ajlm-988	123	29	not	not	PART
ajlm-988	123	30	well	well	ADV
ajlm-988	123	31	studied	study	VERB
ajlm-988	123	32	,	,	PUNCT
ajlm-988	123	33	although	although	SCONJ
ajlm-988	123	34	it	it	PRON
ajlm-988	123	35	has	have	AUX
ajlm-988	123	36	been	be	AUX
ajlm-988	123	37	linked	link	VERB
ajlm-988	123	38	to	to	AUX
ajlm-988	123	39	slow	slow	VERB
ajlm-988	123	40	acetylation	acetylation	NOUN
ajlm-988	123	41	according	accord	VERB
ajlm-988	123	42	to	to	ADP
ajlm-988	123	43	dbsnp.31	dbsnp.31	NOUN
ajlm-988	123	44	another	another	DET
ajlm-988	123	45	variant	variant	NOUN
ajlm-988	123	46	at	at	ADP
ajlm-988	123	47	c.809t	c.809t	PROPN
ajlm-988	123	48	>	>	X
ajlm-988	123	49	c	c	PROPN
ajlm-988	123	50	(	(	PUNCT
ajlm-988	123	51	rs868725509	rs868725509	PROPN
ajlm-988	123	52	)	)	PUNCT
ajlm-988	123	53	is	be	AUX
ajlm-988	123	54	also	also	ADV
ajlm-988	123	55	non	non	ADJ
ajlm-988	123	56	-	-	ADJ
ajlm-988	123	57	synonymous	synonymous	ADJ
ajlm-988	123	58	(	(	PUNCT
ajlm-988	123	59	p.ile270thr	p.ile270thr	NOUN
ajlm-988	123	60	)	)	PUNCT
ajlm-988	123	61	and	and	CCONJ
ajlm-988	123	62	has	have	AUX
ajlm-988	123	63	not	not	PART
ajlm-988	123	64	been	be	AUX
ajlm-988	123	65	characterised	characterise	VERB
ajlm-988	123	66	.	.	PUNCT
ajlm-988	124	1	the	the	DET
ajlm-988	124	2	nonsense	nonsense	ADJ
ajlm-988	124	3	variant	variant	NOUN
ajlm-988	124	4	c.589c	c.589c	PROPN
ajlm-988	124	5	>	>	X
ajlm-988	124	6	t	t	PROPN
ajlm-988	124	7	(	(	PUNCT
ajlm-988	124	8	p.arg197	p.arg197	NOUN
ajlm-988	124	9	*	*	PUNCT
ajlm-988	124	10	)	)	PUNCT
ajlm-988	124	11	results	result	NOUN
ajlm-988	124	12	in	in	ADP
ajlm-988	124	13	a	a	DET
ajlm-988	124	14	stop	stop	NOUN
ajlm-988	124	15	codon	codon	ADJ
ajlm-988	124	16	with	with	ADP
ajlm-988	124	17	a	a	DET
ajlm-988	124	18	subsequent	subsequent	ADJ
ajlm-988	124	19	presumed	presume	VERB
ajlm-988	124	20	lack	lack	NOUN
ajlm-988	124	21	of	of	ADP
ajlm-988	124	22	functional	functional	ADJ
ajlm-988	124	23	protein	protein	NOUN
ajlm-988	124	24	expression.30	expression.30	VERB
ajlm-988	124	25	these	these	DET
ajlm-988	124	26	three	three	NUM
ajlm-988	124	27	snvs	snvs	NOUN
ajlm-988	124	28	each	each	PRON
ajlm-988	124	29	occurred	occur	VERB
ajlm-988	124	30	at	at	ADP
ajlm-988	124	31	a	a	DET
ajlm-988	124	32	frequency	frequency	NOUN
ajlm-988	124	33	of	of	ADP
ajlm-988	124	34	0.5	0.5	NUM
ajlm-988	124	35	%	%	NOUN
ajlm-988	124	36	in	in	ADP
ajlm-988	124	37	the	the	DET
ajlm-988	124	38	study	study	NOUN
ajlm-988	124	39	population	population	NOUN
ajlm-988	124	40	.	.	PUNCT
ajlm-988	125	1	lastly	lastly	ADV
ajlm-988	125	2	,	,	PUNCT
ajlm-988	125	3	the	the	DET
ajlm-988	125	4	very	very	ADV
ajlm-988	125	5	rare	rare	ADJ
ajlm-988	125	6	synonymous	synonymous	ADJ
ajlm-988	125	7	variant	variant	NOUN
ajlm-988	125	8	detected	detect	VERB
ajlm-988	125	9	at	at	ADP
ajlm-988	125	10	position	position	NOUN
ajlm-988	125	11	c.387c	c.387c	VERB
ajlm-988	125	12	>	>	X
ajlm-988	125	13	t	t	PROPN
ajlm-988	125	14	(	(	PUNCT
ajlm-988	125	15	p.ser129=	p.ser129=	PROPN
ajlm-988	125	16	)	)	PUNCT
ajlm-988	125	17	(	(	PUNCT
ajlm-988	125	18	rs144828000	rs144828000	PROPN
ajlm-988	125	19	)	)	PUNCT
ajlm-988	125	20	has	have	AUX
ajlm-988	125	21	to	to	ADP
ajlm-988	125	22	date	date	NOUN
ajlm-988	125	23	not	not	PART
ajlm-988	125	24	been	be	AUX
ajlm-988	125	25	described	describe	VERB
ajlm-988	125	26	in	in	ADP
ajlm-988	125	27	the	the	DET
ajlm-988	125	28	context	context	NOUN
ajlm-988	125	29	of	of	ADP
ajlm-988	125	30	the	the	DET
ajlm-988	125	31	nat2	nat2	NOUN
ajlm-988	125	32	acetylation	acetylation	NOUN
ajlm-988	125	33	status	status	NOUN
ajlm-988	125	34	,	,	PUNCT
ajlm-988	125	35	and	and	CCONJ
ajlm-988	125	36	occurred	occur	VERB
ajlm-988	125	37	in	in	ADP
ajlm-988	125	38	1	1	NUM
ajlm-988	125	39	%	%	NOUN
ajlm-988	125	40	of	of	ADP
ajlm-988	125	41	the	the	DET
ajlm-988	125	42	study	study	NOUN
ajlm-988	125	43	cohort	cohort	NOUN
ajlm-988	125	44	.	.	PUNCT
ajlm-988	126	1	further	further	ADJ
ajlm-988	126	2	assessment	assessment	NOUN
ajlm-988	126	3	of	of	ADP
ajlm-988	126	4	the	the	DET
ajlm-988	126	5	protein	protein	NOUN
ajlm-988	126	6	and	and	CCONJ
ajlm-988	126	7	enzymatic	enzymatic	ADJ
ajlm-988	126	8	activity	activity	NOUN
ajlm-988	126	9	of	of	ADP
ajlm-988	126	10	these	these	DET
ajlm-988	126	11	snvs	snvs	NOUN
ajlm-988	126	12	was	be	AUX
ajlm-988	126	13	not	not	PART
ajlm-988	126	14	within	within	ADP
ajlm-988	126	15	the	the	DET
ajlm-988	126	16	scope	scope	NOUN
ajlm-988	126	17	of	of	ADP
ajlm-988	126	18	this	this	DET
ajlm-988	126	19	study	study	NOUN
ajlm-988	126	20	.	.	PUNCT
ajlm-988	127	1	future	future	ADJ
ajlm-988	127	2	studies	study	NOUN
ajlm-988	127	3	,	,	PUNCT
ajlm-988	127	4	however	however	ADV
ajlm-988	127	5	,	,	PUNCT
ajlm-988	127	6	may	may	AUX
ajlm-988	127	7	investigate	investigate	VERB
ajlm-988	127	8	these	these	DET
ajlm-988	127	9	less	less	ADV
ajlm-988	127	10	commonly	commonly	ADV
ajlm-988	127	11	detected	detect	VERB
ajlm-988	127	12	snvs	snvs	NOUN
ajlm-988	127	13	,	,	PUNCT
ajlm-988	127	14	whether	whether	SCONJ
ajlm-988	127	15	‘	'	PUNCT
ajlm-988	127	16	in	in	ADP
ajlm-988	127	17	silico	silico	NOUN
ajlm-988	127	18	’	'	PUNCT
ajlm-988	127	19	or	or	CCONJ
ajlm-988	127	20	otherwise	otherwise	ADV
ajlm-988	127	21	.	.	PUNCT
ajlm-988	128	1	there	there	PRON
ajlm-988	128	2	are	be	VERB
ajlm-988	128	3	limited	limited	ADJ
ajlm-988	128	4	data	datum	NOUN
ajlm-988	128	5	available	available	ADJ
ajlm-988	128	6	on	on	ADP
ajlm-988	128	7	the	the	DET
ajlm-988	128	8	most	most	ADV
ajlm-988	128	9	commonly	commonly	ADV
ajlm-988	128	10	occurring	occur	VERB
ajlm-988	128	11	nat2	nat2	NOUN
ajlm-988	128	12	haplotypes	haplotype	NOUN
ajlm-988	128	13	in	in	ADP
ajlm-988	128	14	the	the	DET
ajlm-988	128	15	mixed	mixed	ADJ
ajlm-988	128	16	ancestry	ancestry	NOUN
ajlm-988	128	17	population	population	NOUN
ajlm-988	128	18	of	of	ADP
ajlm-988	128	19	the	the	DET
ajlm-988	128	20	western	western	ADJ
ajlm-988	128	21	cape	cape	NOUN
ajlm-988	128	22	,	,	PUNCT
ajlm-988	128	23	although	although	SCONJ
ajlm-988	128	24	numerous	numerous	ADJ
ajlm-988	128	25	studies	study	NOUN
ajlm-988	128	26	have	have	AUX
ajlm-988	128	27	been	be	AUX
ajlm-988	128	28	performed	perform	VERB
ajlm-988	128	29	in	in	ADP
ajlm-988	128	30	other	other	ADJ
ajlm-988	128	31	population	population	NOUN
ajlm-988	128	32	groups	group	NOUN
ajlm-988	128	33	.	.	PUNCT
ajlm-988	129	1	fuselli	fuselli	NOUN
ajlm-988	129	2	et	et	PROPN
ajlm-988	129	3	al	al	PROPN
ajlm-988	129	4	.	.	PROPN
ajlm-988	129	5	demonstrated	demonstrate	VERB
ajlm-988	129	6	a	a	DET
ajlm-988	129	7	preponderance	preponderance	NOUN
ajlm-988	129	8	of	of	ADP
ajlm-988	129	9	nat2	nat2	NOUN
ajlm-988	129	10	*	*	SYM
ajlm-988	129	11	4	4	NUM
ajlm-988	129	12	(	(	PUNCT
ajlm-988	129	13	37	37	NUM
ajlm-988	129	14	%	%	NOUN
ajlm-988	129	15	)	)	PUNCT
ajlm-988	129	16	,	,	PUNCT
ajlm-988	129	17	nat2	nat2	PROPN
ajlm-988	129	18	*	*	PROPN
ajlm-988	129	19	7b	7b	PROPN
ajlm-988	129	20	(	(	PUNCT
ajlm-988	129	21	24	24	NUM
ajlm-988	129	22	%	%	NOUN
ajlm-988	129	23	)	)	PUNCT
ajlm-988	129	24	and	and	CCONJ
ajlm-988	129	25	nat2	nat2	PROPN
ajlm-988	129	26	*	*	PUNCT
ajlm-988	129	27	5b	5b	NUM
ajlm-988	129	28	(	(	PUNCT
ajlm-988	129	29	23	23	NUM
ajlm-988	129	30	%	%	NOUN
ajlm-988	129	31	)	)	PUNCT
ajlm-988	129	32	in	in	ADP
ajlm-988	129	33	13	13	NUM
ajlm-988	129	34	american	american	ADJ
ajlm-988	129	35	and	and	CCONJ
ajlm-988	129	36	two	two	NUM
ajlm-988	129	37	siberian	siberian	ADJ
ajlm-988	129	38	populations.32	populations.32	VERB
ajlm-988	129	39	our	our	PRON
ajlm-988	129	40	study	study	NOUN
ajlm-988	129	41	showed	show	VERB
ajlm-988	129	42	a	a	DET
ajlm-988	129	43	similar	similar	ADJ
ajlm-988	129	44	predominance	predominance	NOUN
ajlm-988	129	45	of	of	ADP
ajlm-988	129	46	nat2	nat2	NOUN
ajlm-988	129	47	*	*	SYM
ajlm-988	129	48	4	4	NUM
ajlm-988	129	49	(	(	PUNCT
ajlm-988	129	50	28	28	NUM
ajlm-988	129	51	%	%	NOUN
ajlm-988	129	52	)	)	PUNCT
ajlm-988	129	53	and	and	CCONJ
ajlm-988	129	54	nat2	nat2	PROPN
ajlm-988	129	55	*	*	PUNCT
ajlm-988	129	56	5b	5b	NUM
ajlm-988	129	57	(	(	PUNCT
ajlm-988	129	58	27.4	27.4	NUM
ajlm-988	129	59	%	%	NOUN
ajlm-988	129	60	)	)	PUNCT
ajlm-988	129	61	,	,	PUNCT
ajlm-988	129	62	while	while	SCONJ
ajlm-988	129	63	the	the	DET
ajlm-988	129	64	frequency	frequency	NOUN
ajlm-988	129	65	of	of	ADP
ajlm-988	129	66	nat2	nat2	PROPN
ajlm-988	129	67	*	*	NOUN
ajlm-988	129	68	7b	7b	PROPN
ajlm-988	129	69	was	be	AUX
ajlm-988	129	70	much	much	ADV
ajlm-988	129	71	lower	low	ADJ
ajlm-988	129	72	(	(	PUNCT
ajlm-988	129	73	3.8	3.8	NUM
ajlm-988	129	74	%	%	NOUN
ajlm-988	129	75	)	)	PUNCT
ajlm-988	129	76	.	.	PUNCT
ajlm-988	130	1	while	while	SCONJ
ajlm-988	130	2	the	the	DET
ajlm-988	130	3	wild	wild	ADJ
ajlm-988	130	4	type	type	NOUN
ajlm-988	130	5	(	(	PUNCT
ajlm-988	130	6	nat2	nat2	NOUN
ajlm-988	130	7	*	*	NOUN
ajlm-988	130	8	4	4	NUM
ajlm-988	130	9	)	)	PUNCT
ajlm-988	130	10	was	be	AUX
ajlm-988	130	11	also	also	ADV
ajlm-988	130	12	the	the	DET
ajlm-988	130	13	most	most	ADV
ajlm-988	130	14	commonly	commonly	ADV
ajlm-988	130	15	occurring	occur	VERB
ajlm-988	130	16	haplotype	haplotype	NOUN
ajlm-988	130	17	in	in	ADP
ajlm-988	130	18	east	east	PROPN
ajlm-988	130	19	asians,33	asians,33	PROPN
ajlm-988	130	20	loktionov	loktionov	PROPN
ajlm-988	130	21	et	et	PROPN
ajlm-988	130	22	al	al	PROPN
ajlm-988	130	23	.	.	PROPN
ajlm-988	130	24	described	describe	VERB
ajlm-988	130	25	nat2	nat2	PROPN
ajlm-988	130	26	*	*	PUNCT
ajlm-988	130	27	5b	5b	NOUN
ajlm-988	130	28	to	to	PART
ajlm-988	130	29	be	be	AUX
ajlm-988	130	30	the	the	DET
ajlm-988	130	31	most	most	ADV
ajlm-988	130	32	common	common	ADJ
ajlm-988	130	33	haplotype	haplotype	NOUN
ajlm-988	130	34	in	in	ADP
ajlm-988	130	35	black	black	ADJ
ajlm-988	130	36	south	south	ADJ
ajlm-988	130	37	africans,34	africans,34	NOUN
ajlm-988	130	38	followed	follow	VERB
ajlm-988	130	39	by	by	ADP
ajlm-988	130	40	nat2	nat2	NOUN
ajlm-988	130	41	*	*	SYM
ajlm-988	130	42	6a	6a	NOUN
ajlm-988	130	43	and	and	CCONJ
ajlm-988	130	44	nat2	nat2	NOUN
ajlm-988	130	45	*	*	NOUN
ajlm-988	130	46	12a	12a	NOUN
ajlm-988	130	47	(	(	PUNCT
ajlm-988	130	48	both	both	DET
ajlm-988	130	49	16.8	16.8	NUM
ajlm-988	130	50	%	%	NOUN
ajlm-988	130	51	,	,	PUNCT
ajlm-988	130	52	vs	vs	ADP
ajlm-988	130	53	21.5	21.5	NUM
ajlm-988	130	54	%	%	NOUN
ajlm-988	130	55	and	and	CCONJ
ajlm-988	130	56	7.5	7.5	NUM
ajlm-988	130	57	%	%	NOUN
ajlm-988	130	58	in	in	ADP
ajlm-988	130	59	our	our	PRON
ajlm-988	130	60	study	study	NOUN
ajlm-988	130	61	population	population	NOUN
ajlm-988	130	62	)	)	PUNCT
ajlm-988	130	63	.	.	PUNCT
ajlm-988	131	1	in	in	ADP
ajlm-988	131	2	contrast	contrast	NOUN
ajlm-988	131	3	to	to	ADP
ajlm-988	131	4	our	our	PRON
ajlm-988	131	5	findings	finding	NOUN
ajlm-988	131	6	,	,	PUNCT
ajlm-988	131	7	the	the	DET
ajlm-988	131	8	wild	wild	ADJ
ajlm-988	131	9	type	type	NOUN
ajlm-988	131	10	nat2	nat2	PROPN
ajlm-988	131	11	*	*	SYM
ajlm-988	131	12	4	4	NUM
ajlm-988	131	13	was	be	AUX
ajlm-988	131	14	shown	show	VERB
ajlm-988	131	15	to	to	PART
ajlm-988	131	16	occur	occur	VERB
ajlm-988	131	17	less	less	ADV
ajlm-988	131	18	frequently	frequently	ADV
ajlm-988	131	19	in	in	ADP
ajlm-988	131	20	black	black	ADJ
ajlm-988	131	21	south	south	PROPN
ajlm-988	131	22	africans	africans	PROPN
ajlm-988	131	23	(	(	PUNCT
ajlm-988	131	24	13.4%).34	13.4%).34	NUM
ajlm-988	131	25	in	in	ADP
ajlm-988	131	26	a	a	DET
ajlm-988	131	27	cohort	cohort	NOUN
ajlm-988	131	28	of	of	ADP
ajlm-988	131	29	62	62	NUM
ajlm-988	131	30	black	black	ADJ
ajlm-988	131	31	and	and	CCONJ
ajlm-988	131	32	54	54	NUM
ajlm-988	131	33	mixed	mixed	ADJ
ajlm-988	131	34	ancestry	ancestry	NOUN
ajlm-988	131	35	south	south	PROPN
ajlm-988	131	36	africans	africans	PROPN
ajlm-988	131	37	,	,	PUNCT
ajlm-988	131	38	where	where	SCONJ
ajlm-988	131	39	17	17	NUM
ajlm-988	131	40	%	%	NOUN
ajlm-988	131	41	were	be	AUX
ajlm-988	131	42	found	find	VERB
ajlm-988	131	43	to	to	PART
ajlm-988	131	44	be	be	AUX
ajlm-988	131	45	fast	fast	ADJ
ajlm-988	131	46	acetylators35	acetylators35	NOUN
ajlm-988	131	47	,	,	PUNCT
ajlm-988	131	48	haplotype	haplotype	NOUN
ajlm-988	131	49	frequencies	frequency	NOUN
ajlm-988	131	50	did	do	AUX
ajlm-988	131	51	not	not	PART
ajlm-988	131	52	differ	differ	VERB
ajlm-988	131	53	significantly	significantly	ADV
ajlm-988	131	54	between	between	ADP
ajlm-988	131	55	the	the	DET
ajlm-988	131	56	two	two	NUM
ajlm-988	131	57	population	population	NOUN
ajlm-988	131	58	groups	group	NOUN
ajlm-988	131	59	(	(	PUNCT
ajlm-988	131	60	unpublished	unpublished	ADJ
ajlm-988	131	61	)	)	PUNCT
ajlm-988	131	62	.	.	PUNCT
ajlm-988	132	1	the	the	DET
ajlm-988	132	2	frequency	frequency	NOUN
ajlm-988	132	3	of	of	ADP
ajlm-988	132	4	nat2	nat2	NOUN
ajlm-988	132	5	haplotypes	haplotype	NOUN
ajlm-988	132	6	obtained	obtain	VERB
ajlm-988	132	7	in	in	ADP
ajlm-988	132	8	this	this	DET
ajlm-988	132	9	study	study	NOUN
ajlm-988	132	10	serve	serve	VERB
ajlm-988	132	11	as	as	ADP
ajlm-988	132	12	a	a	DET
ajlm-988	132	13	priori	priori	ADJ
ajlm-988	132	14	information	information	NOUN
ajlm-988	132	15	to	to	PART
ajlm-988	132	16	strengthen	strengthen	VERB
ajlm-988	132	17	future	future	ADJ
ajlm-988	132	18	haplotype	haplotype	NOUN
ajlm-988	132	19	predictions	prediction	NOUN
ajlm-988	132	20	by	by	ADP
ajlm-988	132	21	computational	computational	ADJ
ajlm-988	132	22	algorithms	algorithm	NOUN
ajlm-988	132	23	such	such	ADJ
ajlm-988	132	24	as	as	ADP
ajlm-988	132	25	phase	phase	NOUN
ajlm-988	132	26	,	,	PUNCT
ajlm-988	132	27	specifically	specifically	ADV
ajlm-988	132	28	in	in	ADP
ajlm-988	132	29	this	this	DET
ajlm-988	132	30	mixed	mixed	ADJ
ajlm-988	132	31	ancestry	ancestry	NOUN
ajlm-988	132	32	population	population	NOUN
ajlm-988	132	33	.	.	PUNCT
ajlm-988	133	1	the	the	DET
ajlm-988	133	2	good	good	ADJ
ajlm-988	133	3	correlation	correlation	NOUN
ajlm-988	133	4	between	between	ADP
ajlm-988	133	5	phase	phase	NOUN
ajlm-988	133	6	and	and	CCONJ
ajlm-988	133	7	molecular	molecular	ADJ
ajlm-988	133	8	haplotyping	haplotyping	ADJ
ajlm-988	133	9	methods	method	NOUN
ajlm-988	133	10	demonstrated	demonstrate	VERB
ajlm-988	133	11	in	in	ADP
ajlm-988	133	12	our	our	PRON
ajlm-988	133	13	mixed	mixed	ADJ
ajlm-988	133	14	ancestry	ancestry	NOUN
ajlm-988	133	15	population	population	NOUN
ajlm-988	133	16	is	be	AUX
ajlm-988	133	17	similar	similar	ADJ
ajlm-988	133	18	to	to	ADP
ajlm-988	133	19	previous	previous	ADJ
ajlm-988	133	20	studies	study	NOUN
ajlm-988	133	21	in	in	ADP
ajlm-988	133	22	other	other	ADJ
ajlm-988	133	23	populations	population	NOUN
ajlm-988	133	24	.	.	PUNCT
ajlm-988	134	1	a	a	DET
ajlm-988	134	2	study	study	NOUN
ajlm-988	134	3	by	by	ADP
ajlm-988	134	4	golka	golka	PROPN
ajlm-988	134	5	et	et	PROPN
ajlm-988	134	6	al	al	PROPN
ajlm-988	134	7	.	.	PROPN
ajlm-988	135	1	in	in	ADP
ajlm-988	135	2	a	a	DET
ajlm-988	135	3	german	german	ADJ
ajlm-988	135	4	population	population	NOUN
ajlm-988	135	5	,	,	PUNCT
ajlm-988	135	6	where	where	SCONJ
ajlm-988	135	7	the	the	DET
ajlm-988	135	8	statistical	statistical	ADJ
ajlm-988	135	9	program	program	NOUN
ajlm-988	135	10	phase	phase	NOUN
ajlm-988	135	11	version	version	NOUN
ajlm-988	135	12	2.1.1	2.1.1	NUM
ajlm-988	135	13	was	be	AUX
ajlm-988	135	14	used	use	VERB
ajlm-988	135	15	to	to	PART
ajlm-988	135	16	predict	predict	VERB
ajlm-988	135	17	haplotypes	haplotype	NOUN
ajlm-988	135	18	from	from	ADP
ajlm-988	135	19	genotypes	genotype	NOUN
ajlm-988	135	20	by	by	ADP
ajlm-988	135	21	analysing	analyse	VERB
ajlm-988	135	22	seven	seven	NUM
ajlm-988	135	23	nat2	nat2	PROPN
ajlm-988	135	24	snvs	snvs	NOUN
ajlm-988	135	25	commonly	commonly	ADV
ajlm-988	135	26	observed	observe	VERB
ajlm-988	135	27	in	in	ADP
ajlm-988	135	28	the	the	DET
ajlm-988	135	29	caucasian	caucasian	ADJ
ajlm-988	135	30	population	population	NOUN
ajlm-988	135	31	,	,	PUNCT
ajlm-988	135	32	concluded	conclude	VERB
ajlm-988	135	33	that	that	SCONJ
ajlm-988	135	34	this	this	DET
ajlm-988	135	35	program	program	NOUN
ajlm-988	135	36	unambiguously	unambiguously	ADV
ajlm-988	135	37	derived	derive	VERB
ajlm-988	135	38	haplotypes	haplotype	NOUN
ajlm-988	135	39	in	in	ADP
ajlm-988	135	40	over	over	ADP
ajlm-988	135	41	99	99	NUM
ajlm-988	135	42	%	%	NOUN
ajlm-988	135	43	of	of	ADP
ajlm-988	135	44	cases.36	cases.36	NOUN
ajlm-988	135	45	similarly	similarly	ADV
ajlm-988	135	46	,	,	PUNCT
ajlm-988	135	47	other	other	ADJ
ajlm-988	135	48	studies	study	NOUN
ajlm-988	135	49	have	have	AUX
ajlm-988	135	50	shown	show	VERB
ajlm-988	135	51	that	that	SCONJ
ajlm-988	135	52	these	these	DET
ajlm-988	135	53	computational	computational	ADJ
ajlm-988	135	54	algorithms	algorithm	NOUN
ajlm-988	135	55	(	(	PUNCT
ajlm-988	135	56	including	include	VERB
ajlm-988	135	57	phase	phase	NOUN
ajlm-988	135	58	)	)	PUNCT
ajlm-988	135	59	compare	compare	VERB
ajlm-988	135	60	well	well	ADV
ajlm-988	135	61	with	with	ADP
ajlm-988	135	62	molecular	molecular	ADJ
ajlm-988	135	63	haplotyping	haplotyping	NOUN
ajlm-988	135	64	,	,	PUNCT
ajlm-988	135	65	and	and	CCONJ
ajlm-988	135	66	could	could	AUX
ajlm-988	135	67	thus	thus	ADV
ajlm-988	135	68	be	be	AUX
ajlm-988	135	69	used	use	VERB
ajlm-988	135	70	as	as	ADP
ajlm-988	135	71	an	an	DET
ajlm-988	135	72	alternative	alternative	ADJ
ajlm-988	135	73	method	method	NOUN
ajlm-988	135	74	for	for	ADP
ajlm-988	135	75	genetic	genetic	ADJ
ajlm-988	135	76	phasing	phasing	NOUN
ajlm-988	135	77	.	.	PUNCT
ajlm-988	136	1	sabbagh	sabbagh	VERB
ajlm-988	136	2	and	and	CCONJ
ajlm-988	136	3	darlu	darlu	NOUN
ajlm-988	136	4	(	(	PUNCT
ajlm-988	136	5	2005	2005	NUM
ajlm-988	136	6	)	)	PUNCT
ajlm-988	136	7	investigated	investigate	VERB
ajlm-988	136	8	the	the	DET
ajlm-988	136	9	performance	performance	NOUN
ajlm-988	136	10	of	of	ADP
ajlm-988	136	11	several	several	ADJ
ajlm-988	136	12	computational	computational	ADJ
ajlm-988	136	13	approaches	approach	NOUN
ajlm-988	136	14	in	in	ADP
ajlm-988	136	15	estimating	estimate	VERB
ajlm-988	136	16	individual	individual	ADJ
ajlm-988	136	17	haplotype	haplotype	NOUN
ajlm-988	136	18	phases	phase	NOUN
ajlm-988	136	19	in	in	ADP
ajlm-988	136	20	five	five	NUM
ajlm-988	136	21	different	different	ADJ
ajlm-988	136	22	population	population	NOUN
ajlm-988	136	23	groups	group	NOUN
ajlm-988	136	24	(	(	PUNCT
ajlm-988	136	25	spanish	spanish	ADJ
ajlm-988	136	26	,	,	PUNCT
ajlm-988	136	27	united	united	PROPN
ajlm-988	136	28	kindom	kindom	PROPN
ajlm-988	136	29	caucasians	caucasians	PROPN
ajlm-988	136	30	,	,	PUNCT
ajlm-988	136	31	black	black	ADJ
ajlm-988	136	32	south	south	PROPN
ajlm-988	136	33	africans	africans	PROPN
ajlm-988	136	34	,	,	PUNCT
ajlm-988	136	35	koreans	koreans	PROPN
ajlm-988	136	36	and	and	CCONJ
ajlm-988	136	37	nicaraguans).17	nicaraguans).17	PROPN
ajlm-988	136	38	they	they	PRON
ajlm-988	136	39	compared	compare	VERB
ajlm-988	136	40	the	the	DET
ajlm-988	136	41	results	result	NOUN
ajlm-988	136	42	obtained	obtain	VERB
ajlm-988	136	43	from	from	ADP
ajlm-988	136	44	the	the	DET
ajlm-988	136	45	computational	computational	ADJ
ajlm-988	136	46	programs	program	NOUN
ajlm-988	136	47	with	with	ADP
ajlm-988	136	48	those	those	PRON
ajlm-988	136	49	obtained	obtain	VERB
ajlm-988	136	50	through	through	ADP
ajlm-988	136	51	direct	direct	ADJ
ajlm-988	136	52	molecular	molecular	ADJ
ajlm-988	136	53	haplotyping	haplotyping	NOUN
ajlm-988	136	54	and	and	CCONJ
ajlm-988	136	55	found	find	VERB
ajlm-988	136	56	that	that	SCONJ
ajlm-988	136	57	even	even	ADV
ajlm-988	136	58	the	the	DET
ajlm-988	136	59	incorrectly	incorrectly	ADV
ajlm-988	136	60	predicted	predict	VERB
ajlm-988	136	61	haplotypes	haplotype	NOUN
ajlm-988	136	62	did	do	AUX
ajlm-988	136	63	not	not	PART
ajlm-988	136	64	result	result	VERB
ajlm-988	136	65	in	in	ADP
ajlm-988	136	66	phenotypic	phenotypic	ADJ
ajlm-988	136	67	changes	change	NOUN
ajlm-988	136	68	,	,	PUNCT
ajlm-988	136	69	resulting	result	VERB
ajlm-988	136	70	in	in	ADP
ajlm-988	136	71	a	a	DET
ajlm-988	136	72	complete	complete	ADJ
ajlm-988	136	73	correlation	correlation	NOUN
ajlm-988	136	74	of	of	ADP
ajlm-988	136	75	the	the	DET
ajlm-988	136	76	acetylation	acetylation	NOUN
ajlm-988	136	77	phenotypes	phenotype	NOUN
ajlm-988	136	78	in	in	ADP
ajlm-988	136	79	all	all	DET
ajlm-988	136	80	five	five	NUM
ajlm-988	136	81	population	population	NOUN
ajlm-988	136	82	groups	group	NOUN
ajlm-988	136	83	.	.	PUNCT
ajlm-988	137	1	the	the	DET
ajlm-988	137	2	population	population	NOUN
ajlm-988	137	3	group	group	NOUN
ajlm-988	137	4	in	in	ADP
ajlm-988	137	5	which	which	PRON
ajlm-988	137	6	computational	computational	ADJ
ajlm-988	137	7	haplotype	haplotype	NOUN
ajlm-988	137	8	inference	inference	NOUN
ajlm-988	137	9	displayed	display	VERB
ajlm-988	137	10	the	the	DET
ajlm-988	137	11	highest	high	ADJ
ajlm-988	137	12	error	error	NOUN
ajlm-988	137	13	rate	rate	NOUN
ajlm-988	137	14	was	be	AUX
ajlm-988	137	15	black	black	ADJ
ajlm-988	137	16	south	south	ADJ
ajlm-988	137	17	africans	africans	PROPN
ajlm-988	137	18	,	,	PUNCT
ajlm-988	137	19	although	although	SCONJ
ajlm-988	137	20	error	error	NOUN
ajlm-988	137	21	rates	rate	NOUN
ajlm-988	137	22	were	be	AUX
ajlm-988	137	23	always	always	ADV
ajlm-988	137	24	low	low	ADJ
ajlm-988	137	25	(	(	PUNCT
ajlm-988	137	26	less	less	ADJ
ajlm-988	137	27	than	than	ADP
ajlm-988	137	28	4	4	NUM
ajlm-988	137	29	%	%	NOUN
ajlm-988	137	30	)	)	PUNCT
ajlm-988	137	31	.	.	PUNCT
ajlm-988	138	1	the	the	DET
ajlm-988	138	2	postulated	postulate	VERB
ajlm-988	138	3	reasons	reason	NOUN
ajlm-988	138	4	include	include	VERB
ajlm-988	138	5	the	the	DET
ajlm-988	138	6	high	high	ADJ
ajlm-988	138	7	number	number	NOUN
ajlm-988	138	8	of	of	ADP
ajlm-988	138	9	ambiguous	ambiguous	ADJ
ajlm-988	138	10	genotypes	genotype	NOUN
ajlm-988	138	11	as	as	ADV
ajlm-988	138	12	well	well	ADV
ajlm-988	138	13	as	as	ADP
ajlm-988	138	14	the	the	DET
ajlm-988	138	15	low	low	ADJ
ajlm-988	138	16	rate	rate	NOUN
ajlm-988	138	17	of	of	ADP
ajlm-988	138	18	linkage	linkage	NOUN
ajlm-988	138	19	disequilibrium	disequilibrium	NOUN
ajlm-988	138	20	between	between	ADP
ajlm-988	138	21	the	the	DET
ajlm-988	138	22	various	various	ADJ
ajlm-988	138	23	snvs	snvs	NOUN
ajlm-988	138	24	in	in	ADP
ajlm-988	138	25	this	this	DET
ajlm-988	138	26	sample	sample	NOUN
ajlm-988	138	27	,	,	PUNCT
ajlm-988	138	28	compared	compare	VERB
ajlm-988	138	29	with	with	ADP
ajlm-988	138	30	the	the	DET
ajlm-988	138	31	other	other	ADJ
ajlm-988	138	32	four	four	NUM
ajlm-988	138	33	population	population	NOUN
ajlm-988	138	34	groups.17	groups.17	NOUN
ajlm-988	138	35	the	the	DET
ajlm-988	138	36	authors	author	NOUN
ajlm-988	138	37	suggest	suggest	VERB
ajlm-988	138	38	studying	study	VERB
ajlm-988	138	39	these	these	DET
ajlm-988	138	40	data	datum	NOUN
ajlm-988	138	41	before	before	SCONJ
ajlm-988	138	42	computational	computational	ADJ
ajlm-988	138	43	haplotyping	haplotyping	NOUN
ajlm-988	138	44	is	be	AUX
ajlm-988	138	45	employed	employ	VERB
ajlm-988	138	46	,	,	PUNCT
ajlm-988	138	47	to	to	PART
ajlm-988	138	48	attempt	attempt	VERB
ajlm-988	138	49	to	to	PART
ajlm-988	138	50	predict	predict	VERB
ajlm-988	138	51	the	the	DET
ajlm-988	138	52	accuracy	accuracy	NOUN
ajlm-988	138	53	and	and	CCONJ
ajlm-988	138	54	reliability	reliability	NOUN
ajlm-988	138	55	with	with	ADP
ajlm-988	138	56	which	which	PRON
ajlm-988	138	57	haplotypes	haplotype	NOUN
ajlm-988	138	58	will	will	AUX
ajlm-988	138	59	subsequently	subsequently	ADV
ajlm-988	138	60	be	be	AUX
ajlm-988	138	61	inferred	infer	VERB
ajlm-988	138	62	in	in	ADP
ajlm-988	138	63	such	such	ADJ
ajlm-988	138	64	cases	case	NOUN
ajlm-988	138	65	.	.	PUNCT
ajlm-988	139	1	the	the	DET
ajlm-988	139	2	single	single	ADJ
ajlm-988	139	3	incorrectly	incorrectly	ADV
ajlm-988	139	4	predicted	predict	VERB
ajlm-988	139	5	phenotype	phenotype	NOUN
ajlm-988	139	6	(	(	PUNCT
ajlm-988	139	7	intermediate	intermediate	ADJ
ajlm-988	139	8	to	to	PART
ajlm-988	139	9	slow	slow	VERB
ajlm-988	139	10	)	)	PUNCT
ajlm-988	139	11	may	may	AUX
ajlm-988	139	12	be	be	AUX
ajlm-988	139	13	clinically	clinically	ADV
ajlm-988	139	14	significant	significant	ADJ
ajlm-988	139	15	.	.	PUNCT
ajlm-988	140	1	however	however	ADV
ajlm-988	140	2	,	,	PUNCT
ajlm-988	140	3	the	the	DET
ajlm-988	140	4	computational	computational	ADJ
ajlm-988	140	5	program	program	NOUN
ajlm-988	140	6	flagged	flag	VERB
ajlm-988	140	7	the	the	DET
ajlm-988	140	8	predicted	predict	VERB
ajlm-988	140	9	haplotypes	haplotype	NOUN
ajlm-988	140	10	as	as	ADP
ajlm-988	140	11	being	be	AUX
ajlm-988	140	12	uncertain	uncertain	ADJ
ajlm-988	140	13	;	;	PUNCT
ajlm-988	140	14	in	in	ADP
ajlm-988	140	15	the	the	DET
ajlm-988	140	16	clinical	clinical	ADJ
ajlm-988	140	17	scenario	scenario	NOUN
ajlm-988	140	18	,	,	PUNCT
ajlm-988	140	19	such	such	DET
ajlm-988	140	20	a	a	DET
ajlm-988	140	21	flag	flag	NOUN
ajlm-988	140	22	could	could	AUX
ajlm-988	140	23	serve	serve	VERB
ajlm-988	140	24	as	as	ADP
ajlm-988	140	25	a	a	DET
ajlm-988	140	26	prompt	prompt	NOUN
ajlm-988	140	27	to	to	PART
ajlm-988	140	28	confirm	confirm	VERB
ajlm-988	140	29	the	the	DET
ajlm-988	140	30	haplotype	haplotype	NOUN
ajlm-988	140	31	by	by	ADP
ajlm-988	140	32	molecular	molecular	ADJ
ajlm-988	140	33	methods	method	NOUN
ajlm-988	140	34	instead	instead	ADV
ajlm-988	140	35	of	of	ADP
ajlm-988	140	36	relying	rely	VERB
ajlm-988	140	37	on	on	ADP
ajlm-988	140	38	phase	phase	NOUN
ajlm-988	140	39	.	.	PUNCT
ajlm-988	141	1	in	in	ADP
ajlm-988	141	2	our	our	PRON
ajlm-988	141	3	current	current	ADJ
ajlm-988	141	4	setting	setting	NOUN
ajlm-988	141	5	,	,	PUNCT
ajlm-988	141	6	nat2	nat2	NOUN
ajlm-988	141	7	acetylation	acetylation	NOUN
ajlm-988	141	8	status	status	NOUN
ajlm-988	141	9	is	be	AUX
ajlm-988	141	10	chiefly	chiefly	ADV
ajlm-988	141	11	investigated	investigate	VERB
ajlm-988	141	12	by	by	ADP
ajlm-988	141	13	special	special	ADJ
ajlm-988	141	14	request	request	NOUN
ajlm-988	141	15	once	once	SCONJ
ajlm-988	141	16	the	the	DET
ajlm-988	141	17	patient	patient	NOUN
ajlm-988	141	18	has	have	VERB
ajlm-988	141	19	hepatic	hepatic	ADJ
ajlm-988	141	20	complications	complication	NOUN
ajlm-988	141	21	of	of	ADP
ajlm-988	141	22	isoniazid	isoniazid	NOUN
ajlm-988	141	23	therapy	therapy	NOUN
ajlm-988	141	24	.	.	PUNCT
ajlm-988	142	1	apart	apart	ADV
ajlm-988	142	2	from	from	ADP
ajlm-988	142	3	the	the	DET
ajlm-988	142	4	adverse	adverse	ADJ
ajlm-988	142	5	drug	drug	NOUN
ajlm-988	142	6	reactions	reaction	NOUN
ajlm-988	142	7	that	that	PRON
ajlm-988	142	8	could	could	AUX
ajlm-988	142	9	be	be	AUX
ajlm-988	142	10	avoided	avoid	VERB
ajlm-988	142	11	by	by	ADP
ajlm-988	142	12	individualising	individualise	VERB
ajlm-988	142	13	isoniazid	isoniazid	NOUN
ajlm-988	142	14	dosage	dosage	NOUN
ajlm-988	142	15	according	accord	VERB
ajlm-988	142	16	to	to	ADP
ajlm-988	142	17	nat2	nat2	NOUN
ajlm-988	142	18	phenotypes	phenotype	NOUN
ajlm-988	142	19	,	,	PUNCT
ajlm-988	142	20	incorrect	incorrect	ADJ
ajlm-988	142	21	dosage	dosage	NOUN
ajlm-988	142	22	may	may	AUX
ajlm-988	142	23	contribute	contribute	VERB
ajlm-988	142	24	to	to	ADP
ajlm-988	142	25	the	the	DET
ajlm-988	142	26	growing	grow	VERB
ajlm-988	142	27	prevalence	prevalence	NOUN
ajlm-988	142	28	of	of	ADP
ajlm-988	142	29	multi	multi	ADJ
ajlm-988	142	30	-	-	ADJ
ajlm-988	142	31	drug	drug	ADJ
ajlm-988	142	32	resistant	resistant	ADJ
ajlm-988	142	33	tuberculosis.37	tuberculosis.37	PROPN
ajlm-988	142	34	the	the	DET
ajlm-988	142	35	unavailability	unavailability	NOUN
ajlm-988	142	36	of	of	ADP
ajlm-988	142	37	routine	routine	ADJ
ajlm-988	142	38	isoniazid	isoniazid	NOUN
ajlm-988	142	39	genotyping	genotype	VERB
ajlm-988	142	40	could	could	AUX
ajlm-988	142	41	thus	thus	ADV
ajlm-988	142	42	be	be	AUX
ajlm-988	142	43	considered	consider	VERB
ajlm-988	142	44	a	a	DET
ajlm-988	142	45	major	major	ADJ
ajlm-988	142	46	limitation	limitation	NOUN
ajlm-988	142	47	of	of	ADP
ajlm-988	142	48	current	current	ADJ
ajlm-988	142	49	tuberculosis	tuberculosis	NOUN
ajlm-988	142	50	treatment	treatment	NOUN
ajlm-988	142	51	protocols	protocol	NOUN
ajlm-988	142	52	.	.	PUNCT
ajlm-988	143	1	n	n	CCONJ
ajlm-988	143	2	-	-	PUNCT
ajlm-988	143	3	acetyltransferase	acetyltransferase	NOUN
ajlm-988	143	4	2	2	NUM
ajlm-988	143	5	genotyping	genotyping	NOUN
ajlm-988	143	6	should	should	AUX
ajlm-988	143	7	ideally	ideally	ADV
ajlm-988	143	8	be	be	AUX
ajlm-988	143	9	performed	perform	VERB
ajlm-988	143	10	on	on	ADP
ajlm-988	143	11	all	all	DET
ajlm-988	143	12	patients	patient	NOUN
ajlm-988	143	13	before	before	ADP
ajlm-988	143	14	commencing	commence	VERB
ajlm-988	143	15	isoniazid	isoniazid	NOUN
ajlm-988	143	16	therapy	therapy	NOUN
ajlm-988	143	17	.	.	PUNCT
ajlm-988	144	1	the	the	DET
ajlm-988	144	2	cost	cost	NOUN
ajlm-988	144	3	of	of	ADP
ajlm-988	144	4	genetic	genetic	ADJ
ajlm-988	144	5	investigations	investigation	NOUN
ajlm-988	144	6	as	as	ADV
ajlm-988	144	7	well	well	ADV
ajlm-988	144	8	as	as	ADP
ajlm-988	144	9	the	the	DET
ajlm-988	144	10	limited	limited	ADJ
ajlm-988	144	11	infrastructure	infrastructure	NOUN
ajlm-988	144	12	in	in	ADP
ajlm-988	144	13	the	the	DET
ajlm-988	144	14	south	south	ADJ
ajlm-988	144	15	african	african	ADJ
ajlm-988	144	16	healthcare	healthcare	NOUN
ajlm-988	144	17	setting	set	VERB
ajlm-988	144	18	make	make	VERB
ajlm-988	144	19	it	it	PRON
ajlm-988	144	20	difficult	difficult	ADJ
ajlm-988	144	21	to	to	PART
ajlm-988	144	22	apply	apply	VERB
ajlm-988	144	23	haplotyping	haplotyping	NOUN
ajlm-988	144	24	without	without	ADP
ajlm-988	144	25	the	the	DET
ajlm-988	144	26	phase	phase	NOUN
ajlm-988	144	27	computational	computational	ADJ
ajlm-988	144	28	approach	approach	NOUN
ajlm-988	144	29	.	.	PUNCT
ajlm-988	145	1	this	this	DET
ajlm-988	145	2	approach	approach	NOUN
ajlm-988	145	3	could	could	AUX
ajlm-988	145	4	be	be	AUX
ajlm-988	145	5	supported	support	VERB
ajlm-988	145	6	by	by	ADP
ajlm-988	145	7	specific	specific	ADJ
ajlm-988	145	8	investigation	investigation	NOUN
ajlm-988	145	9	of	of	ADP
ajlm-988	145	10	incompletely	incompletely	ADV
ajlm-988	145	11	explored	explore	VERB
ajlm-988	145	12	snvs	snvs	NOUN
ajlm-988	145	13	and	and	CCONJ
ajlm-988	145	14	the	the	DET
ajlm-988	145	15	development	development	NOUN
ajlm-988	145	16	of	of	ADP
ajlm-988	145	17	a	a	DET
ajlm-988	145	18	high	high	ADJ
ajlm-988	145	19	throughput	throughput	NOUN
ajlm-988	145	20	multiplex	multiplex	PROPN
ajlm-988	145	21	assay	assay	NOUN
ajlm-988	145	22	targeting	target	VERB
ajlm-988	145	23	common	common	ADJ
ajlm-988	145	24	snvs	snvs	NOUN
ajlm-988	145	25	relevant	relevant	ADJ
ajlm-988	145	26	to	to	ADP
ajlm-988	145	27	the	the	DET
ajlm-988	145	28	population	population	NOUN
ajlm-988	145	29	being	be	AUX
ajlm-988	145	30	investigated	investigate	VERB
ajlm-988	145	31	.	.	PUNCT
ajlm-988	146	1	further	further	ADJ
ajlm-988	146	2	studies	study	NOUN
ajlm-988	146	3	are	be	AUX
ajlm-988	146	4	also	also	ADV
ajlm-988	146	5	recommended	recommend	VERB
ajlm-988	146	6	to	to	PART
ajlm-988	146	7	investigate	investigate	VERB
ajlm-988	146	8	and	and	CCONJ
ajlm-988	146	9	monitor	monitor	VERB
ajlm-988	146	10	the	the	DET
ajlm-988	146	11	isoniazid	isoniazid	NOUN
ajlm-988	146	12	safety	safety	NOUN
ajlm-988	146	13	and	and	CCONJ
ajlm-988	146	14	treatment	treatment	NOUN
ajlm-988	146	15	outcome	outcome	NOUN
ajlm-988	146	16	in	in	ADP
ajlm-988	146	17	patients	patient	NOUN
ajlm-988	146	18	undergoing	undergo	VERB
ajlm-988	146	19	treatment	treatment	NOUN
ajlm-988	146	20	for	for	ADP
ajlm-988	146	21	tuberculosis	tuberculosis	NOUN
ajlm-988	146	22	with	with	ADP
ajlm-988	146	23	different	different	ADJ
ajlm-988	146	24	nat2	nat2	NOUN
ajlm-988	146	25	acetylation	acetylation	NOUN
ajlm-988	146	26	phenotypes	phenotype	NOUN
ajlm-988	146	27	.	.	PUNCT
ajlm-988	147	1	limitations	limitation	NOUN
ajlm-988	147	2	due	due	ADP
ajlm-988	147	3	to	to	ADP
ajlm-988	147	4	budgetary	budgetary	ADJ
ajlm-988	147	5	and	and	CCONJ
ajlm-988	147	6	time	time	NOUN
ajlm-988	147	7	constraints	constraint	NOUN
ajlm-988	147	8	,	,	PUNCT
ajlm-988	147	9	only	only	ADV
ajlm-988	147	10	a	a	DET
ajlm-988	147	11	small	small	ADJ
ajlm-988	147	12	sample	sample	NOUN
ajlm-988	147	13	size	size	NOUN
ajlm-988	147	14	of	of	ADP
ajlm-988	147	15	100	100	NUM
ajlm-988	147	16	was	be	AUX
ajlm-988	147	17	used	use	VERB
ajlm-988	147	18	.	.	PUNCT
ajlm-988	148	1	the	the	DET
ajlm-988	148	2	arms	arm	NOUN
ajlm-988	148	3	pcr	pcr	NOUN
ajlm-988	148	4	could	could	AUX
ajlm-988	148	5	not	not	PART
ajlm-988	148	6	be	be	AUX
ajlm-988	148	7	set	set	VERB
ajlm-988	148	8	up	up	ADP
ajlm-988	148	9	for	for	ADP
ajlm-988	148	10	the	the	DET
ajlm-988	148	11	following	follow	VERB
ajlm-988	148	12	variants	variant	NOUN
ajlm-988	148	13	which	which	PRON
ajlm-988	148	14	may	may	AUX
ajlm-988	148	15	have	have	AUX
ajlm-988	148	16	improved	improve	VERB
ajlm-988	148	17	the	the	DET
ajlm-988	148	18	correlation	correlation	NOUN
ajlm-988	148	19	:	:	PUNCT
ajlm-988	148	20	c.590g	c.590g	NOUN
ajlm-988	148	21	>	>	X
ajlm-988	148	22	a	a	PRON
ajlm-988	148	23	,	,	PUNCT
ajlm-988	148	24	c.857g	c.857g	NOUN
ajlm-988	148	25	>	>	X
ajlm-988	148	26	a	a	PRON
ajlm-988	148	27	,	,	PUNCT
ajlm-988	148	28	c.341t	c.341t	NOUN
ajlm-988	148	29	>	>	X
ajlm-988	148	30	c	c	PROPN
ajlm-988	148	31	and	and	CCONJ
ajlm-988	148	32	c.803a	c.803a	PROPN
ajlm-988	148	33	>	>	NOUN
ajlm-988	148	34	g.	g.	PROPN
ajlm-988	149	1	conclusion	conclusion	NOUN
ajlm-988	149	2	phase	phase	NOUN
ajlm-988	149	3	accurately	accurately	ADV
ajlm-988	149	4	predicted	predict	VERB
ajlm-988	149	5	the	the	DET
ajlm-988	149	6	nat2	nat2	NOUN
ajlm-988	149	7	acetylation	acetylation	NOUN
ajlm-988	149	8	phenotype	phenotype	NOUN
ajlm-988	149	9	in	in	ADP
ajlm-988	149	10	92	92	NUM
ajlm-988	149	11	of	of	ADP
ajlm-988	149	12	93	93	NUM
ajlm-988	149	13	samples	sample	NOUN
ajlm-988	149	14	(	(	PUNCT
ajlm-988	149	15	99	99	NUM
ajlm-988	149	16	%	%	NOUN
ajlm-988	149	17	)	)	PUNCT
ajlm-988	149	18	from	from	ADP
ajlm-988	149	19	genotypic	genotypic	ADJ
ajlm-988	149	20	data	datum	NOUN
ajlm-988	149	21	in	in	ADP
ajlm-988	149	22	our	our	PRON
ajlm-988	149	23	mixed	mixed	ADJ
ajlm-988	149	24	ancestry	ancestry	NOUN
ajlm-988	149	25	study	study	NOUN
ajlm-988	149	26	population	population	NOUN
ajlm-988	149	27	,	,	PUNCT
ajlm-988	149	28	and	and	CCONJ
ajlm-988	149	29	could	could	AUX
ajlm-988	149	30	be	be	AUX
ajlm-988	149	31	used	use	VERB
ajlm-988	149	32	as	as	ADP
ajlm-988	149	33	an	an	DET
ajlm-988	149	34	alternative	alternative	NOUN
ajlm-988	149	35	to	to	ADP
ajlm-988	149	36	molecular	molecular	ADJ
ajlm-988	149	37	methods	method	NOUN
ajlm-988	149	38	to	to	PART
ajlm-988	149	39	individualise	individualise	VERB
ajlm-988	149	40	isoniazid	isoniazid	NOUN
ajlm-988	149	41	therapy	therapy	NOUN
ajlm-988	149	42	in	in	ADP
ajlm-988	149	43	our	our	PRON
ajlm-988	149	44	high	high	ADJ
ajlm-988	149	45	tuberculosis	tuberculosis	NOUN
ajlm-988	149	46	burden	burden	NOUN
ajlm-988	149	47	setting	setting	NOUN
ajlm-988	149	48	.	.	PUNCT
ajlm-988	150	1	data	datum	NOUN
ajlm-988	150	2	obtained	obtain	VERB
ajlm-988	150	3	from	from	ADP
ajlm-988	150	4	this	this	DET
ajlm-988	150	5	study	study	NOUN
ajlm-988	150	6	may	may	AUX
ajlm-988	150	7	also	also	ADV
ajlm-988	150	8	be	be	AUX
ajlm-988	150	9	potentially	potentially	ADV
ajlm-988	150	10	used	use	VERB
ajlm-988	150	11	to	to	PART
ajlm-988	150	12	predict	predict	VERB
ajlm-988	150	13	haplotypes	haplotype	NOUN
ajlm-988	150	14	in	in	ADP
ajlm-988	150	15	future	future	ADJ
ajlm-988	150	16	patients	patient	NOUN
ajlm-988	150	17	from	from	ADP
ajlm-988	150	18	this	this	DET
ajlm-988	150	19	population	population	NOUN
ajlm-988	150	20	group	group	NOUN
ajlm-988	150	21	.	.	PUNCT
ajlm-988	151	1	acknowledgements	acknowledgement	NOUN
ajlm-988	151	2	competing	compete	VERB
ajlm-988	151	3	interests	interest	NOUN
ajlm-988	151	4	the	the	DET
ajlm-988	151	5	authors	author	NOUN
ajlm-988	151	6	have	have	AUX
ajlm-988	151	7	declared	declare	VERB
ajlm-988	151	8	that	that	SCONJ
ajlm-988	151	9	no	no	DET
ajlm-988	151	10	competing	compete	VERB
ajlm-988	151	11	interest	interest	NOUN
ajlm-988	151	12	exists	exist	VERB
ajlm-988	151	13	.	.	PUNCT
ajlm-988	152	1	authors	author	NOUN
ajlm-988	152	2	’	'	PUNCT
ajlm-988	152	3	contributions	contribution	NOUN
ajlm-988	152	4	c.s	c.s	PROPN
ajlm-988	152	5	.	.	PROPN
ajlm-988	152	6	was	be	AUX
ajlm-988	152	7	the	the	DET
ajlm-988	152	8	primary	primary	ADJ
ajlm-988	152	9	author	author	NOUN
ajlm-988	152	10	and	and	CCONJ
ajlm-988	152	11	performed	perform	VERB
ajlm-988	152	12	the	the	DET
ajlm-988	152	13	majority	majority	NOUN
ajlm-988	152	14	of	of	ADP
ajlm-988	152	15	the	the	DET
ajlm-988	152	16	molecular	molecular	ADJ
ajlm-988	152	17	work	work	NOUN
ajlm-988	152	18	and	and	CCONJ
ajlm-988	152	19	subsequent	subsequent	ADJ
ajlm-988	152	20	analyses	analysis	NOUN
ajlm-988	152	21	.	.	PUNCT
ajlm-988	153	1	all	all	DET
ajlm-988	153	2	co	co	NOUN
ajlm-988	153	3	-	-	NOUN
ajlm-988	153	4	authors	author	NOUN
ajlm-988	153	5	assisted	assist	VERB
ajlm-988	153	6	with	with	ADP
ajlm-988	153	7	the	the	DET
ajlm-988	153	8	reviewing	reviewing	NOUN
ajlm-988	153	9	of	of	ADP
ajlm-988	153	10	the	the	DET
ajlm-988	153	11	manuscript	manuscript	NOUN
ajlm-988	153	12	.	.	PUNCT
ajlm-988	154	1	f.o	f.o	PROPN
ajlm-988	154	2	.	.	PROPN
ajlm-988	154	3	was	be	AUX
ajlm-988	154	4	the	the	DET
ajlm-988	154	5	supervisor	supervisor	NOUN
ajlm-988	154	6	and	and	CCONJ
ajlm-988	154	7	assisted	assist	VERB
ajlm-988	154	8	with	with	ADP
ajlm-988	154	9	the	the	DET
ajlm-988	154	10	project	project	NOUN
ajlm-988	154	11	design	design	NOUN
ajlm-988	154	12	,	,	PUNCT
ajlm-988	154	13	and	and	CCONJ
ajlm-988	154	14	s.m	s.m	PROPN
ajlm-988	154	15	.	.	PROPN
ajlm-988	154	16	assisted	assist	VERB
ajlm-988	154	17	with	with	ADP
ajlm-988	154	18	molecular	molecular	ADJ
ajlm-988	154	19	bench	bench	NOUN
ajlm-988	154	20	work	work	NOUN
ajlm-988	154	21	and	and	CCONJ
ajlm-988	154	22	interpretation	interpretation	NOUN
ajlm-988	154	23	of	of	ADP
ajlm-988	154	24	results	result	NOUN
ajlm-988	154	25	.	.	PUNCT
ajlm-988	155	1	a.d.m	a.d.m	INTJ
ajlm-988	155	2	.	.	PUNCT
ajlm-988	155	3	was	be	AUX
ajlm-988	155	4	responsible	responsible	ADJ
ajlm-988	155	5	for	for	ADP
ajlm-988	155	6	the	the	DET
ajlm-988	155	7	funding	funding	NOUN
ajlm-988	155	8	,	,	PUNCT
ajlm-988	155	9	and	and	CCONJ
ajlm-988	155	10	provided	provide	VERB
ajlm-988	155	11	the	the	DET
ajlm-988	155	12	source	source	NOUN
ajlm-988	155	13	of	of	ADP
ajlm-988	155	14	samples	sample	NOUN
ajlm-988	155	15	utilised	utilise	VERB
ajlm-988	155	16	in	in	ADP
ajlm-988	155	17	this	this	DET
ajlm-988	155	18	study	study	NOUN
ajlm-988	155	19	.	.	PUNCT
ajlm-988	156	1	c.m.c	c.m.c	PROPN
ajlm-988	156	2	.	.	PUNCT
ajlm-988	157	1	was	be	AUX
ajlm-988	157	2	responsible	responsible	ADJ
ajlm-988	157	3	for	for	ADP
ajlm-988	157	4	running	run	VERB
ajlm-988	157	5	the	the	DET
ajlm-988	157	6	phase	phase	NOUN
ajlm-988	157	7	computational	computational	ADJ
ajlm-988	157	8	haplotype	haplotype	NOUN
ajlm-988	157	9	predictions	prediction	NOUN
ajlm-988	157	10	as	as	ADV
ajlm-988	157	11	well	well	ADV
ajlm-988	157	12	as	as	ADP
ajlm-988	157	13	the	the	DET
ajlm-988	157	14	statistical	statistical	ADJ
ajlm-988	157	15	analysis	analysis	NOUN
ajlm-988	157	16	.	.	PUNCT
ajlm-988	158	1	sources	source	NOUN
ajlm-988	158	2	of	of	ADP
ajlm-988	158	3	support	support	NOUN
ajlm-988	158	4	research	research	NOUN
ajlm-988	158	5	conducted	conduct	VERB
ajlm-988	158	6	in	in	ADP
ajlm-988	158	7	this	this	DET
ajlm-988	158	8	study	study	NOUN
ajlm-988	158	9	was	be	AUX
ajlm-988	158	10	supported	support	VERB
ajlm-988	158	11	by	by	ADP
ajlm-988	158	12	existing	exist	VERB
ajlm-988	158	13	internal	internal	ADJ
ajlm-988	158	14	research	research	NOUN
ajlm-988	158	15	funds	fund	NOUN
ajlm-988	158	16	from	from	ADP
ajlm-988	158	17	the	the	DET
ajlm-988	158	18	university	university	PROPN
ajlm-988	158	19	of	of	ADP
ajlm-988	158	20	cape	cape	PROPN
ajlm-988	158	21	town	town	NOUN
ajlm-988	158	22	.	.	PUNCT
ajlm-988	159	1	data	datum	NOUN
ajlm-988	159	2	availability	availability	NOUN
ajlm-988	159	3	statement	statement	NOUN
ajlm-988	159	4	data	datum	NOUN
ajlm-988	159	5	sharing	sharing	NOUN
ajlm-988	159	6	is	be	AUX
ajlm-988	159	7	not	not	PART
ajlm-988	159	8	applicable	applicable	ADJ
ajlm-988	159	9	to	to	ADP
ajlm-988	159	10	this	this	DET
ajlm-988	159	11	article	article	NOUN
ajlm-988	159	12	as	as	SCONJ
ajlm-988	159	13	no	no	DET
ajlm-988	159	14	new	new	ADJ
ajlm-988	159	15	data	datum	NOUN
ajlm-988	159	16	were	be	AUX
ajlm-988	159	17	created	create	VERB
ajlm-988	159	18	or	or	CCONJ
ajlm-988	159	19	analysed	analyse	VERB
ajlm-988	159	20	in	in	ADP
ajlm-988	159	21	this	this	DET
ajlm-988	159	22	study	study	NOUN
ajlm-988	159	23	.	.	PUNCT
ajlm-988	160	1	disclaimer	disclaimer	VERB
ajlm-988	160	2	the	the	DET
ajlm-988	160	3	views	view	NOUN
ajlm-988	160	4	and	and	CCONJ
ajlm-988	160	5	opinions	opinion	NOUN
ajlm-988	160	6	expressed	express	VERB
ajlm-988	160	7	in	in	ADP
ajlm-988	160	8	this	this	DET
ajlm-988	160	9	article	article	NOUN
ajlm-988	160	10	are	be	AUX
ajlm-988	160	11	those	those	PRON
ajlm-988	160	12	of	of	ADP
ajlm-988	160	13	the	the	DET
ajlm-988	160	14	authors	author	NOUN
ajlm-988	160	15	and	and	CCONJ
ajlm-988	160	16	do	do	AUX
ajlm-988	160	17	not	not	PART
ajlm-988	160	18	necessarily	necessarily	ADV
ajlm-988	160	19	reflect	reflect	VERB
ajlm-988	160	20	the	the	DET
ajlm-988	160	21	official	official	ADJ
ajlm-988	160	22	policy	policy	NOUN
ajlm-988	160	23	or	or	CCONJ
ajlm-988	160	24	position	position	NOUN
ajlm-988	160	25	of	of	ADP
ajlm-988	160	26	any	any	DET
ajlm-988	160	27	affiliated	affiliated	ADJ
ajlm-988	160	28	agency	agency	NOUN
ajlm-988	160	29	of	of	ADP
ajlm-988	160	30	the	the	DET
ajlm-988	160	31	authors	author	NOUN
ajlm-988	160	32	.	.	PUNCT
ajlm-988	161	1	references	reference	NOUN
ajlm-988	161	2	mandal	mandal	PROPN
ajlm-988	161	3	a.	a.	NOUN
ajlm-988	161	4	history	history	NOUN
ajlm-988	161	5	of	of	ADP
ajlm-988	161	6	tuberculosis	tuberculosis	NOUN
ajlm-988	162	1	[	[	X
ajlm-988	162	2	homepage	homepage	NOUN
ajlm-988	162	3	on	on	ADP
ajlm-988	162	4	the	the	DET
ajlm-988	162	5	internet	internet	NOUN
ajlm-988	162	6	]	]	PUNCT
ajlm-988	162	7	.	.	PUNCT
ajlm-988	162	8	2014	2014	NUM
ajlm-988	163	1	[	[	X
ajlm-988	163	2	accessed	access	VERB
ajlm-988	163	3	2020	2020	NUM
ajlm-988	163	4	sep	sep	NOUN
ajlm-988	163	5	7	7	NUM
ajlm-988	163	6	]	]	PUNCT
ajlm-988	163	7	.	.	PUNCT
ajlm-988	164	1	available	available	ADJ
ajlm-988	164	2	from	from	ADP
ajlm-988	164	3	:	:	PUNCT
ajlm-988	164	4	http://www.news-medical.net/health/history-of-tuberculosis.aspx	http://www.news-medical.net/health/history-of-tuberculosis.aspx	PROPN
ajlm-988	164	5	south	south	ADJ
ajlm-988	164	6	african	african	ADJ
ajlm-988	164	7	national	national	PROPN
ajlm-988	164	8	aids	aids	PROPN
ajlm-988	164	9	council	council	PROPN
ajlm-988	164	10	(	(	PUNCT
ajlm-988	164	11	sanac	sanac	NOUN
ajlm-988	164	12	)	)	PUNCT
ajlm-988	164	13	.	.	PUNCT
ajlm-988	165	1	national	national	ADJ
ajlm-988	165	2	strategic	strategic	ADJ
ajlm-988	165	3	plan	plan	NOUN
ajlm-988	165	4	on	on	ADP
ajlm-988	165	5	hiv	hiv	PROPN
ajlm-988	165	6	,	,	PUNCT
ajlm-988	165	7	stis	stis	PROPN
ajlm-988	165	8	and	and	CCONJ
ajlm-988	165	9	tb	tb	ADP
ajlm-988	165	10	2012–2016	2012–2016	NUM
ajlm-988	166	1	[	[	NOUN
ajlm-988	166	2	homepage	homepage	NOUN
ajlm-988	166	3	on	on	ADP
ajlm-988	166	4	the	the	DET
ajlm-988	166	5	internet	internet	NOUN
ajlm-988	166	6	]	]	PUNCT
ajlm-988	166	7	.	.	PUNCT
ajlm-988	167	1	sanac	sanac	ADJ
ajlm-988	167	2	;	;	PUNCT
ajlm-988	167	3	2011	2011	NUM
ajlm-988	167	4	[	[	X
ajlm-988	167	5	accessed	access	VERB
ajlm-988	167	6	2020	2020	NUM
ajlm-988	167	7	sep	sep	NOUN
ajlm-988	167	8	7	7	NUM
ajlm-988	167	9	]	]	PUNCT
ajlm-988	167	10	.	.	PUNCT
ajlm-988	168	1	available	available	ADJ
ajlm-988	168	2	from	from	ADP
ajlm-988	168	3	:	:	PUNCT
ajlm-988	168	4	https://www.hst.org.za/publications/nonhst%20publications/hiv-nsp.pdf	https://www.hst.org.za/publications/nonhst%20publications/hiv-nsp.pdf	PROPN
ajlm-988	168	5	beyers	beyers	PROPN
ajlm-988	168	6	n	n	CCONJ
ajlm-988	168	7	,	,	PUNCT
ajlm-988	168	8	gie	gie	NOUN
ajlm-988	168	9	rp	rp	NOUN
ajlm-988	168	10	,	,	PUNCT
ajlm-988	168	11	zietsman	zietsman	NOUN
ajlm-988	168	12	hl	hl	PROPN
ajlm-988	168	13	,	,	PUNCT
ajlm-988	168	14	et	et	PROPN
ajlm-988	168	15	al	al	PROPN
ajlm-988	168	16	.	.	PUNCT
ajlm-988	169	1	the	the	DET
ajlm-988	169	2	use	use	NOUN
ajlm-988	169	3	of	of	ADP
ajlm-988	169	4	a	a	DET
ajlm-988	169	5	geographical	geographical	ADJ
ajlm-988	169	6	information	information	NOUN
ajlm-988	169	7	system	system	NOUN
ajlm-988	169	8	(	(	PUNCT
ajlm-988	169	9	gis	gis	NOUN
ajlm-988	169	10	)	)	PUNCT
ajlm-988	169	11	to	to	PART
ajlm-988	169	12	evaluate	evaluate	VERB
ajlm-988	169	13	the	the	DET
ajlm-988	169	14	distribution	distribution	NOUN
ajlm-988	169	15	of	of	ADP
ajlm-988	169	16	tuberculosis	tuberculosis	NOUN
ajlm-988	169	17	in	in	ADP
ajlm-988	169	18	a	a	DET
ajlm-988	169	19	high	high	ADJ
ajlm-988	169	20	-	-	PUNCT
ajlm-988	169	21	incidence	incidence	NOUN
ajlm-988	169	22	community	community	NOUN
ajlm-988	169	23	.	.	PUNCT
ajlm-988	170	1	s	s	PROPN
ajlm-988	170	2	afr	afr	PROPN
ajlm-988	170	3	med	med	PROPN
ajlm-988	170	4	j.	j.	PROPN
ajlm-988	170	5	1996;86(1):40–44	1996;86(1):40–44	PROPN
ajlm-988	170	6	.	.	PROPN
ajlm-988	171	1	world	world	PROPN
ajlm-988	171	2	health	health	PROPN
ajlm-988	171	3	organization	organization	PROPN
ajlm-988	171	4	.	.	PUNCT
ajlm-988	172	1	treatment	treatment	NOUN
ajlm-988	172	2	of	of	ADP
ajlm-988	172	3	tuberculosis	tuberculosis	NOUN
ajlm-988	172	4	:	:	PUNCT
ajlm-988	172	5	guidelines	guideline	NOUN
ajlm-988	172	6	.	.	PUNCT
ajlm-988	173	1	who	who	PRON
ajlm-988	173	2	/	/	SYM
ajlm-988	173	3	htm	htm	PROPN
ajlm-988	173	4	/	/	SYM
ajlm-988	173	5	tb/2009.420	tb/2009.420	PROPN
ajlm-988	173	6	.	.	PUNCT
ajlm-988	174	1	4th	4th	ADJ
ajlm-988	174	2	ed	ed	NOUN
ajlm-988	174	3	.	.	PUNCT
ajlm-988	175	1	geneva	geneva	PROPN
ajlm-988	175	2	:	:	PUNCT
ajlm-988	175	3	world	world	PROPN
ajlm-988	175	4	health	health	NOUN
ajlm-988	175	5	organization	organization	NOUN
ajlm-988	175	6	;	;	PUNCT
ajlm-988	175	7	2009	2009	NUM
ajlm-988	175	8	.	.	PUNCT
ajlm-988	176	1	weber	weber	PROPN
ajlm-988	176	2	ww	ww	PROPN
ajlm-988	176	3	,	,	PUNCT
ajlm-988	176	4	hein	hein	PROPN
ajlm-988	176	5	dw	dw	PROPN
ajlm-988	176	6	.	.	PROPN
ajlm-988	176	7	n	n	CCONJ
ajlm-988	176	8	-	-	PUNCT
ajlm-988	176	9	acetylation	acetylation	NOUN
ajlm-988	176	10	pharmacogenetics	pharmacogenetic	NOUN
ajlm-988	176	11	.	.	PUNCT
ajlm-988	177	1	pharmacol	pharmacol	PROPN
ajlm-988	177	2	rev	rev	VERB
ajlm-988	177	3	[	[	X
ajlm-988	177	4	serial	serial	ADJ
ajlm-988	177	5	online	online	NOUN
ajlm-988	177	6	]	]	X
ajlm-988	177	7	.	.	PUNCT
ajlm-988	178	1	1985;37(1):25–79	1985;37(1):25–79	X
ajlm-988	178	2	.	.	PUNCT
ajlm-988	178	3	available	available	ADJ
ajlm-988	178	4	from	from	ADP
ajlm-988	178	5	:	:	PUNCT
ajlm-988	178	6	https://doi.org/10.2165/00003088-197702030-00003	https://doi.org/10.2165/00003088-197702030-00003	NOUN
ajlm-988	178	7	matas	matas	PROPN
ajlm-988	178	8	n	n	CCONJ
ajlm-988	178	9	,	,	PUNCT
ajlm-988	178	10	thygesen	thygesen	NOUN
ajlm-988	178	11	p	p	PROPN
ajlm-988	178	12	,	,	PUNCT
ajlm-988	178	13	stacey	stacey	PROPN
ajlm-988	178	14	m	m	PROPN
ajlm-988	178	15	,	,	PUNCT
ajlm-988	178	16	risch	risch	VERB
ajlm-988	178	17	a	a	PRON
ajlm-988	178	18	,	,	PUNCT
ajlm-988	178	19	sim	sim	ADJ
ajlm-988	178	20	e.	e.	PROPN
ajlm-988	178	21	mapping	mapping	PROPN
ajlm-988	178	22	aac1	aac1	PROPN
ajlm-988	178	23	,	,	PUNCT
ajlm-988	178	24	aac2	aac2	NOUN
ajlm-988	178	25	and	and	CCONJ
ajlm-988	178	26	aacp	aacp	NOUN
ajlm-988	178	27	,	,	PUNCT
ajlm-988	178	28	the	the	DET
ajlm-988	178	29	genes	gene	NOUN
ajlm-988	178	30	for	for	ADP
ajlm-988	178	31	arylamine	arylamine	NOUN
ajlm-988	178	32	n	n	CCONJ
ajlm-988	178	33	-	-	PUNCT
ajlm-988	178	34	acetyltransferases	acetyltransferase	NOUN
ajlm-988	178	35	,	,	PUNCT
ajlm-988	178	36	carcinogen	carcinogen	NOUN
ajlm-988	178	37	metabolising	metabolise	VERB
ajlm-988	178	38	enzymes	enzyme	NOUN
ajlm-988	178	39	on	on	ADP
ajlm-988	178	40	human	human	ADJ
ajlm-988	178	41	chromosome	chromosome	NOUN
ajlm-988	178	42	8p22	8p22	NOUN
ajlm-988	178	43	,	,	PUNCT
ajlm-988	178	44	a	a	DET
ajlm-988	178	45	region	region	NOUN
ajlm-988	178	46	frequently	frequently	ADV
ajlm-988	178	47	deleted	delete	VERB
ajlm-988	178	48	in	in	ADP
ajlm-988	178	49	tumours	tumours	PROPN
ajlm-988	178	50	.	.	PUNCT
ajlm-988	179	1	cytogenet	cytogenet	NOUN
ajlm-988	179	2	cell	cell	NOUN
ajlm-988	179	3	genet	genet	NOUN
ajlm-988	179	4	.	.	PUNCT
ajlm-988	180	1	1997;77(3–4):290–295	1997;77(3–4):290–295	NOUN
ajlm-988	180	2	.	.	PUNCT
ajlm-988	181	1	https://doi.org/10.1159/000134601	https://doi.org/10.1159/000134601	PROPN
ajlm-988	181	2	franke	franke	PROPN
ajlm-988	181	3	s	s	PROPN
ajlm-988	181	4	,	,	PUNCT
ajlm-988	181	5	klawitz	klawitz	PROPN
ajlm-988	182	1	i	i	PRON
ajlm-988	182	2	,	,	PUNCT
ajlm-988	182	3	schnakenberg	schnakenberg	PROPN
ajlm-988	182	4	e	e	PROPN
ajlm-988	182	5	,	,	PUNCT
ajlm-988	182	6	et	et	PROPN
ajlm-988	182	7	al	al	PROPN
ajlm-988	182	8	.	.	PUNCT
ajlm-988	182	9	isolation	isolation	NOUN
ajlm-988	182	10	and	and	CCONJ
ajlm-988	182	11	mapping	mapping	NOUN
ajlm-988	182	12	of	of	ADP
ajlm-988	182	13	a	a	DET
ajlm-988	182	14	cosmid	cosmid	NOUN
ajlm-988	182	15	clone	clone	NOUN
ajlm-988	182	16	containing	contain	VERB
ajlm-988	182	17	the	the	DET
ajlm-988	182	18	human	human	ADJ
ajlm-988	182	19	nat	nat	NOUN
ajlm-988	182	20	2	2	NUM
ajlm-988	182	21	gene	gene	NOUN
ajlm-988	182	22	.	.	PUNCT
ajlm-988	183	1	biochem	biochem	PROPN
ajlm-988	183	2	biophys	biophy	VERB
ajlm-988	183	3	res	re	NOUN
ajlm-988	183	4	commun	commun	PROPN
ajlm-988	183	5	.	.	PUNCT
ajlm-988	184	1	1994;199(1):52–55	1994;199(1):52–55	X
ajlm-988	184	2	.	.	PUNCT
ajlm-988	185	1	https://doi.org/10.1006/bbrc.1994.1192	https://doi.org/10.1006/bbrc.1994.1192	PROPN
ajlm-988	185	2	hickman	hickman	PROPN
ajlm-988	185	3	d	d	PROPN
ajlm-988	185	4	,	,	PUNCT
ajlm-988	185	5	risch	risch	VERB
ajlm-988	185	6	a	a	PRON
ajlm-988	185	7	,	,	PUNCT
ajlm-988	185	8	buckle	buckle	NOUN
ajlm-988	185	9	v	v	NOUN
ajlm-988	185	10	,	,	PUNCT
ajlm-988	185	11	et	et	PROPN
ajlm-988	185	12	al	al	PROPN
ajlm-988	185	13	.	.	PROPN
ajlm-988	186	1	chromosomal	chromosomal	ADJ
ajlm-988	186	2	localization	localization	NOUN
ajlm-988	186	3	of	of	ADP
ajlm-988	186	4	human	human	ADJ
ajlm-988	186	5	genes	gene	NOUN
ajlm-988	186	6	for	for	ADP
ajlm-988	186	7	arylamine	arylamine	NOUN
ajlm-988	186	8	n	n	CCONJ
ajlm-988	186	9	-	-	PUNCT
ajlm-988	186	10	acetyltransferase	acetyltransferase	NOUN
ajlm-988	186	11	.	.	PUNCT
ajlm-988	187	1	biochem	biochem	PROPN
ajlm-988	187	2	j.	j.	PROPN
ajlm-988	188	1	1994;297(pt	1994;297(pt	PROPN
ajlm-988	188	2	3):441–445	3):441–445	NUM
ajlm-988	188	3	.	.	PUNCT
ajlm-988	189	1	https://doi.org/10.1042/bj2970441	https://doi.org/10.1042/bj2970441	PROPN
ajlm-988	189	2	husain	husain	PROPN
ajlm-988	189	3	a	a	PROPN
ajlm-988	189	4	,	,	PUNCT
ajlm-988	189	5	zhang	zhang	PROPN
ajlm-988	189	6	x	x	PROPN
ajlm-988	189	7	,	,	PUNCT
ajlm-988	189	8	doll	doll	PROPN
ajlm-988	189	9	ma	ma	PROPN
ajlm-988	189	10	,	,	PUNCT
ajlm-988	189	11	states	states	PROPN
ajlm-988	189	12	jc	jc	PROPN
ajlm-988	189	13	,	,	PUNCT
ajlm-988	189	14	barker	barker	PROPN
ajlm-988	189	15	df	df	PROPN
ajlm-988	189	16	,	,	PUNCT
ajlm-988	189	17	hein	hein	PROPN
ajlm-988	189	18	dw	dw	PROPN
ajlm-988	189	19	.	.	PROPN
ajlm-988	189	20	identification	identification	NOUN
ajlm-988	189	21	of	of	ADP
ajlm-988	189	22	n	n	CCONJ
ajlm-988	189	23	-	-	PUNCT
ajlm-988	189	24	acetyltransferase	acetyltransferase	ADJ
ajlm-988	189	25	2	2	NUM
ajlm-988	189	26	(	(	PUNCT
ajlm-988	189	27	nat2	nat2	NOUN
ajlm-988	189	28	)	)	PUNCT
ajlm-988	189	29	transcription	transcription	NOUN
ajlm-988	189	30	start	start	VERB
ajlm-988	189	31	sites	site	NOUN
ajlm-988	189	32	and	and	CCONJ
ajlm-988	189	33	quantitation	quantitation	NOUN
ajlm-988	189	34	of	of	ADP
ajlm-988	189	35	nat2	nat2	NOUN
ajlm-988	189	36	-	-	PUNCT
ajlm-988	189	37	specific	specific	ADJ
ajlm-988	189	38	mrna	mrna	NOUN
ajlm-988	189	39	in	in	ADP
ajlm-988	189	40	human	human	ADJ
ajlm-988	189	41	tissues	tissue	NOUN
ajlm-988	189	42	.	.	PUNCT
ajlm-988	190	1	drug	drug	NOUN
ajlm-988	190	2	metab	metab	PROPN
ajlm-988	190	3	dispos	dispos	PROPN
ajlm-988	190	4	.	.	PUNCT
ajlm-988	191	1	2007;35(5):721–727	2007;35(5):721–727	NUM
ajlm-988	191	2	.	.	PUNCT
ajlm-988	192	1	https://doi.org/10.1124/dmd.106.014621	https://doi.org/10.1124/dmd.106.014621	PROPN
ajlm-988	192	2	blum	blum	PROPN
ajlm-988	192	3	m	m	PROPN
ajlm-988	192	4	,	,	PUNCT
ajlm-988	192	5	grant	grant	PROPN
ajlm-988	192	6	dm	dm	PROPN
ajlm-988	192	7	,	,	PUNCT
ajlm-988	192	8	mcbride	mcbride	PROPN
ajlm-988	192	9	w	w	PROPN
ajlm-988	192	10	,	,	PUNCT
ajlm-988	192	11	heim	heim	PROPN
ajlm-988	192	12	m	m	PROPN
ajlm-988	192	13	,	,	PUNCT
ajlm-988	192	14	meyer	meyer	PROPN
ajlm-988	192	15	ua	ua	PROPN
ajlm-988	192	16	.	.	PUNCT
ajlm-988	193	1	human	human	ADJ
ajlm-988	193	2	arylamine	arylamine	PROPN
ajlm-988	193	3	n	n	CCONJ
ajlm-988	193	4	-	-	PUNCT
ajlm-988	193	5	acetyltransferase	acetyltransferase	NOUN
ajlm-988	193	6	genes	gene	NOUN
ajlm-988	193	7	:	:	PUNCT
ajlm-988	193	8	isolation	isolation	NOUN
ajlm-988	193	9	,	,	PUNCT
ajlm-988	193	10	chromosomal	chromosomal	ADJ
ajlm-988	193	11	localization	localization	NOUN
ajlm-988	193	12	,	,	PUNCT
ajlm-988	193	13	and	and	CCONJ
ajlm-988	193	14	functional	functional	ADJ
ajlm-988	193	15	expression	expression	NOUN
ajlm-988	193	16	.	.	PUNCT
ajlm-988	194	1	dna	dna	PROPN
ajlm-988	194	2	cell	cell	NOUN
ajlm-988	194	3	biol	biol	NOUN
ajlm-988	194	4	.	.	PUNCT
ajlm-988	195	1	1990;9(3):193–203	1990;9(3):193–203	NUM
ajlm-988	195	2	.	.	PUNCT
ajlm-988	195	3	https://doi.org/10.1089/dna.1990.9.193	https://doi.org/10.1089/dna.1990.9.193	ADP
ajlm-988	195	4	blum	blum	PROPN
ajlm-988	195	5	m	m	PROPN
ajlm-988	195	6	,	,	PUNCT
ajlm-988	195	7	demierre	demierre	ADJ
ajlm-988	195	8	a	a	X
ajlm-988	195	9	,	,	PUNCT
ajlm-988	195	10	grant	grant	PROPN
ajlm-988	195	11	dm	dm	PROPN
ajlm-988	195	12	,	,	PUNCT
ajlm-988	195	13	heim	heim	PROPN
ajlm-988	195	14	m	m	PROPN
ajlm-988	195	15	,	,	PUNCT
ajlm-988	195	16	meyer	meyer	PROPN
ajlm-988	195	17	ua	ua	PROPN
ajlm-988	195	18	.	.	PUNCT
ajlm-988	195	19	molecular	molecular	ADJ
ajlm-988	195	20	mechanism	mechanism	NOUN
ajlm-988	195	21	of	of	ADP
ajlm-988	195	22	slow	slow	ADJ
ajlm-988	195	23	acetylation	acetylation	NOUN
ajlm-988	195	24	of	of	ADP
ajlm-988	195	25	drugs	drug	NOUN
ajlm-988	195	26	and	and	CCONJ
ajlm-988	195	27	carcinogens	carcinogen	NOUN
ajlm-988	195	28	in	in	ADP
ajlm-988	195	29	humans	human	NOUN
ajlm-988	195	30	.	.	PUNCT
ajlm-988	196	1	proc	proc	PROPN
ajlm-988	196	2	natl	natl	PROPN
ajlm-988	196	3	acad	acad	PROPN
ajlm-988	196	4	sci	sci	PROPN
ajlm-988	196	5	u	u	PROPN
ajlm-988	196	6	s	s	PROPN
ajlm-988	196	7	a.	a.	NOUN
ajlm-988	196	8	1991;88(12):5237–5241	1991;88(12):5237–5241	NUM
ajlm-988	196	9	.	.	PUNCT
ajlm-988	197	1	https://doi.org/10.1073/pnas.88.12.523712	https://doi.org/10.1073/pnas.88.12.523712	NOUN
ajlm-988	197	2	meisel	meisel	PROPN
ajlm-988	197	3	p.	p.	PROPN
ajlm-988	197	4	arylamine	arylamine	PROPN
ajlm-988	197	5	n	n	CCONJ
ajlm-988	197	6	-	-	PUNCT
ajlm-988	197	7	acetyltransferases	acetyltransferase	NOUN
ajlm-988	197	8	and	and	CCONJ
ajlm-988	197	9	drug	drug	NOUN
ajlm-988	197	10	response	response	NOUN
ajlm-988	197	11	.	.	PUNCT
ajlm-988	198	1	pharmacogenomics	pharmacogenomic	NOUN
ajlm-988	198	2	.	.	PUNCT
ajlm-988	199	1	2002;3(3):349–366	2002;3(3):349–366	NUM
ajlm-988	199	2	.	.	PUNCT
ajlm-988	199	3	https://doi.org/10.1517/14622416.3.3.349	https://doi.org/10.1517/14622416.3.3.349	PROPN
ajlm-988	199	4	wang	wang	PROPN
ajlm-988	199	5	p	p	PROPN
ajlm-988	199	6	,	,	PUNCT
ajlm-988	199	7	pradhan	pradhan	PROPN
ajlm-988	199	8	k	k	PROPN
ajlm-988	199	9	,	,	PUNCT
ajlm-988	199	10	zhong	zhong	PROPN
ajlm-988	199	11	x	x	PROPN
ajlm-988	199	12	,	,	PUNCT
ajlm-988	199	13	ma	ma	PROPN
ajlm-988	199	14	x.	x.	PROPN
ajlm-988	199	15	isoniazid	isoniazid	PROPN
ajlm-988	199	16	metabolism	metabolism	NOUN
ajlm-988	199	17	and	and	CCONJ
ajlm-988	199	18	hepatotoxicity	hepatotoxicity	NOUN
ajlm-988	199	19	.	.	PUNCT
ajlm-988	200	1	acta	acta	PROPN
ajlm-988	200	2	pharmaceutica	pharmaceutica	PROPN
ajlm-988	200	3	sinica	sinica	PROPN
ajlm-988	200	4	b.	b.	PROPN
ajlm-988	200	5	2016;6(5):384–392	2016;6(5):384–392	NUM
ajlm-988	200	6	.	.	PUNCT
ajlm-988	201	1	https://doi.org/10.1016/j.apsb.2016.07.014	https://doi.org/10.1016/j.apsb.2016.07.014	PROPN
ajlm-988	201	2	sabbagh	sabbagh	PROPN
ajlm-988	201	3	a	a	PRON
ajlm-988	201	4	,	,	PUNCT
ajlm-988	201	5	darlu	darlu	NOUN
ajlm-988	201	6	p	p	NOUN
ajlm-988	201	7	,	,	PUNCT
ajlm-988	201	8	crouau	crouau	NOUN
ajlm-988	201	9	-	-	PUNCT
ajlm-988	201	10	roy	roy	PROPN
ajlm-988	201	11	b	b	PROPN
ajlm-988	201	12	,	,	PUNCT
ajlm-988	201	13	poloni	poloni	PROPN
ajlm-988	201	14	es	es	PROPN
ajlm-988	201	15	.	.	PUNCT
ajlm-988	201	16	arylamine	arylamine	PROPN
ajlm-988	201	17	n	n	CCONJ
ajlm-988	201	18	-	-	PUNCT
ajlm-988	201	19	acetyltransferase	acetyltransferase	ADJ
ajlm-988	201	20	2	2	NUM
ajlm-988	201	21	(	(	PUNCT
ajlm-988	201	22	nat2	nat2	NOUN
ajlm-988	201	23	)	)	PUNCT
ajlm-988	201	24	genetic	genetic	ADJ
ajlm-988	201	25	diversity	diversity	NOUN
ajlm-988	201	26	and	and	CCONJ
ajlm-988	201	27	traditional	traditional	ADJ
ajlm-988	201	28	subsistence	subsistence	NOUN
ajlm-988	201	29	:	:	PUNCT
ajlm-988	201	30	a	a	DET
ajlm-988	201	31	worldwide	worldwide	ADJ
ajlm-988	201	32	population	population	NOUN
ajlm-988	201	33	survey	survey	NOUN
ajlm-988	201	34	.	.	PUNCT
ajlm-988	202	1	plos	plos	PROPN
ajlm-988	202	2	one	one	NUM
ajlm-988	202	3	.	.	PUNCT
ajlm-988	203	1	2011;6(4):e18507	2011;6(4):e18507	NUM
ajlm-988	203	2	.	.	PUNCT
ajlm-988	203	3	https://doi.org/10.1371/journal.pone.0018507	https://doi.org/10.1371/journal.pone.0018507	PROPN
ajlm-988	203	4	duth	duth	PROPN
ajlm-988	203	5	.	.	PUNCT
ajlm-988	204	1	human	human	PROPN
ajlm-988	204	2	nat2	nat2	PROPN
ajlm-988	204	3	alleles	allele	NOUN
ajlm-988	204	4	(	(	PUNCT
ajlm-988	204	5	haplotypes	haplotype	NOUN
ajlm-988	204	6	)	)	PUNCT
ajlm-988	204	7	.	.	PUNCT
ajlm-988	205	1	2013	2013	NUM
ajlm-988	206	1	[	[	X
ajlm-988	206	2	updated	update	VERB
ajlm-988	206	3	2016	2016	NUM
ajlm-988	206	4	;	;	PUNCT
ajlm-988	206	5	accessed	access	VERB
ajlm-988	206	6	2020	2020	NUM
ajlm-988	206	7	sep	sep	PROPN
ajlm-988	206	8	7	7	NUM
ajlm-988	206	9	]	]	PUNCT
ajlm-988	206	10	.	.	PUNCT
ajlm-988	207	1	available	available	ADJ
ajlm-988	207	2	from	from	ADP
ajlm-988	207	3	:	:	PUNCT
ajlm-988	207	4	http://nat.mbg.duth.gr/human%20nat2%20alleles_2013.htm	http://nat.mbg.duth.gr/human%20nat2%20alleles_2013.htm	PROPN
ajlm-988	207	5	snpedia	snpedia	PROPN
ajlm-988	207	6	.	.	PUNCT
ajlm-988	208	1	nat2	nat2	PROPN
ajlm-988	208	2	.	.	PUNCT
ajlm-988	209	1	2020	2020	NUM
ajlm-988	210	1	[	[	X
ajlm-988	210	2	accessed	access	VERB
ajlm-988	210	3	2020	2020	NUM
ajlm-988	210	4	sep	sep	PROPN
ajlm-988	210	5	7	7	NUM
ajlm-988	210	6	]	]	PUNCT
ajlm-988	210	7	.	.	PUNCT
ajlm-988	211	1	available	available	ADJ
ajlm-988	211	2	from	from	ADP
ajlm-988	211	3	:	:	PUNCT
ajlm-988	211	4	http://www.snpedia.com/index.php/nat2	http://www.snpedia.com/index.php/nat2	X
ajlm-988	211	5	.	.	PUNCT
ajlm-988	212	1	sabbagh	sabbagh	VERB
ajlm-988	212	2	a	a	DET
ajlm-988	212	3	,	,	PUNCT
ajlm-988	212	4	darlu	darlu	NOUN
ajlm-988	212	5	p.	p.	NOUN
ajlm-988	212	6	inferring	infer	VERB
ajlm-988	212	7	haplotypes	haplotype	NOUN
ajlm-988	212	8	at	at	ADP
ajlm-988	212	9	the	the	DET
ajlm-988	212	10	nat2	nat2	NOUN
ajlm-988	212	11	locus	locus	NOUN
ajlm-988	212	12	:	:	PUNCT
ajlm-988	212	13	the	the	DET
ajlm-988	212	14	computational	computational	ADJ
ajlm-988	212	15	approach	approach	NOUN
ajlm-988	212	16	.	.	PUNCT
ajlm-988	213	1	bmc	bmc	PROPN
ajlm-988	213	2	genet	genet	PROPN
ajlm-988	213	3	.	.	PUNCT
ajlm-988	214	1	2005;6	2005;6	NUM
ajlm-988	214	2	:	:	PUNCT
ajlm-988	214	3	a30	a30	NOUN
ajlm-988	214	4	.	.	PUNCT
ajlm-988	214	5	https://doi.org/10.1186/1471-2156-6-30	https://doi.org/10.1186/1471-2156-6-30	X
ajlm-988	215	1	ahmadian	ahmadian	ADJ
ajlm-988	215	2	a.	a.	NOUN
ajlm-988	215	3	approaches	approach	VERB
ajlm-988	215	4	for	for	ADP
ajlm-988	215	5	analysis	analysis	NOUN
ajlm-988	215	6	of	of	ADP
ajlm-988	215	7	mutations	mutation	NOUN
ajlm-988	215	8	and	and	CCONJ
ajlm-988	215	9	genetic	genetic	ADJ
ajlm-988	215	10	variations	variation	NOUN
ajlm-988	215	11	.	.	PUNCT
ajlm-988	216	1	stockholm	stockholm	PROPN
ajlm-988	216	2	:	:	PUNCT
ajlm-988	216	3	kth	kth	PROPN
ajlm-988	216	4	,	,	PUNCT
ajlm-988	216	5	superseded	supersede	VERB
ajlm-988	216	6	departments	department	NOUN
ajlm-988	216	7	,	,	PUNCT
ajlm-988	216	8	biotechnology	biotechnology	NOUN
ajlm-988	216	9	;	;	PUNCT
ajlm-988	216	10	2001	2001	NUM
ajlm-988	216	11	.	.	PUNCT
ajlm-988	217	1	niu	niu	PROPN
ajlm-988	217	2	t.	t.	PROPN
ajlm-988	217	3	algorithms	algorithm	NOUN
ajlm-988	217	4	for	for	ADP
ajlm-988	217	5	inferring	infer	VERB
ajlm-988	217	6	haplotypes	haplotype	NOUN
ajlm-988	217	7	.	.	PUNCT
ajlm-988	218	1	genet	genet	PROPN
ajlm-988	218	2	epidemiol	epidemiol	PROPN
ajlm-988	218	3	.	.	PUNCT
ajlm-988	219	1	2004;27(4):334–347	2004;27(4):334–347	X
ajlm-988	219	2	.	.	NOUN
ajlm-988	219	3	https://doi.org/10.1002/gepi.20024	https://doi.org/10.1002/gepi.20024	VERB
ajlm-988	219	4	delaneau	delaneau	PROPN
ajlm-988	219	5	o	o	NOUN
ajlm-988	219	6	,	,	PUNCT
ajlm-988	219	7	zagury	zagury	PROPN
ajlm-988	219	8	jf	jf	PROPN
ajlm-988	219	9	.	.	PROPN
ajlm-988	219	10	haplotype	haplotype	PROPN
ajlm-988	219	11	inference	inference	PROPN
ajlm-988	219	12	.	.	PUNCT
ajlm-988	220	1	methods	method	NOUN
ajlm-988	220	2	mol	mol	ADP
ajlm-988	220	3	biol	biol	PROPN
ajlm-988	220	4	.	.	PUNCT
ajlm-988	221	1	2012;888:177–196	2012;888:177–196	NOUN
ajlm-988	221	2	.	.	PUNCT
ajlm-988	222	1	https://doi.org/10.1007/978-1-61779-870-2_11	https://doi.org/10.1007/978-1-61779-870-2_11	PROPN
ajlm-988	222	2	stephens	stephen	NOUN
ajlm-988	222	3	m	m	PROPN
ajlm-988	222	4	,	,	PUNCT
ajlm-988	222	5	donnelly	donnelly	PROPN
ajlm-988	222	6	p.	p.	NOUN
ajlm-988	222	7	a	a	DET
ajlm-988	222	8	comparison	comparison	NOUN
ajlm-988	222	9	of	of	ADP
ajlm-988	222	10	bayesian	bayesian	NOUN
ajlm-988	222	11	methods	method	NOUN
ajlm-988	222	12	for	for	ADP
ajlm-988	222	13	haplotype	haplotype	ADJ
ajlm-988	222	14	reconstruction	reconstruction	NOUN
ajlm-988	222	15	from	from	ADP
ajlm-988	222	16	population	population	NOUN
ajlm-988	222	17	genotype	genotype	NOUN
ajlm-988	222	18	data	data	PROPN
ajlm-988	222	19	.	.	PUNCT
ajlm-988	223	1	am	be	AUX
ajlm-988	223	2	j	j	PROPN
ajlm-988	223	3	hum	hum	PROPN
ajlm-988	223	4	genet	genet	PROPN
ajlm-988	223	5	.	.	PUNCT
ajlm-988	224	1	2003;73(5):1162–1169	2003;73(5):1162–1169	NUM
ajlm-988	224	2	.	.	PUNCT
ajlm-988	225	1	https://doi.org/10.1086/379378	https://doi.org/10.1086/379378	X
ajlm-988	225	2	stephens	stephens	PROPN
ajlm-988	225	3	m	m	PROPN
ajlm-988	225	4	,	,	PUNCT
ajlm-988	225	5	smith	smith	PROPN
ajlm-988	225	6	nj	nj	PROPN
ajlm-988	225	7	,	,	PUNCT
ajlm-988	225	8	donnelly	donnelly	PROPN
ajlm-988	225	9	p.	p.	PROPN
ajlm-988	225	10	a	a	DET
ajlm-988	225	11	new	new	ADJ
ajlm-988	225	12	statistical	statistical	ADJ
ajlm-988	225	13	method	method	NOUN
ajlm-988	225	14	for	for	ADP
ajlm-988	225	15	haplotype	haplotype	ADJ
ajlm-988	225	16	reconstruction	reconstruction	NOUN
ajlm-988	225	17	from	from	ADP
ajlm-988	225	18	population	population	NOUN
ajlm-988	225	19	data	datum	NOUN
ajlm-988	225	20	.	.	PUNCT
ajlm-988	226	1	am	be	AUX
ajlm-988	226	2	j	j	PROPN
ajlm-988	226	3	hum	hum	PROPN
ajlm-988	226	4	genet	genet	PROPN
ajlm-988	226	5	.	.	PUNCT
ajlm-988	227	1	2001;68(4):978–989	2001;68(4):978–989	X
ajlm-988	227	2	.	.	PUNCT
ajlm-988	227	3	https://doi.org/10.1086/319501	https://doi.org/10.1086/319501	PROPN
ajlm-988	227	4	zhang	zhang	PROPN
ajlm-988	227	5	m	m	PROPN
ajlm-988	227	6	,	,	PUNCT
ajlm-988	227	7	wang	wang	PROPN
ajlm-988	227	8	s	s	PROPN
ajlm-988	227	9	,	,	PUNCT
ajlm-988	227	10	wilffert	wilffert	NOUN
ajlm-988	227	11	b	b	PROPN
ajlm-988	227	12	,	,	PUNCT
ajlm-988	227	13	et	et	PROPN
ajlm-988	227	14	al	al	PROPN
ajlm-988	227	15	.	.	PUNCT
ajlm-988	228	1	the	the	DET
ajlm-988	228	2	association	association	NOUN
ajlm-988	228	3	between	between	ADP
ajlm-988	228	4	the	the	DET
ajlm-988	228	5	nat2	nat2	NOUN
ajlm-988	228	6	genetic	genetic	ADJ
ajlm-988	228	7	polymorphisms	polymorphism	NOUN
ajlm-988	228	8	and	and	CCONJ
ajlm-988	228	9	risk	risk	NOUN
ajlm-988	228	10	of	of	ADP
ajlm-988	228	11	dili	dili	PROPN
ajlm-988	228	12	during	during	ADP
ajlm-988	228	13	antitb	antitb	NOUN
ajlm-988	228	14	treatment	treatment	NOUN
ajlm-988	228	15	:	:	PUNCT
ajlm-988	228	16	a	a	DET
ajlm-988	228	17	systematic	systematic	ADJ
ajlm-988	228	18	review	review	NOUN
ajlm-988	228	19	and	and	CCONJ
ajlm-988	228	20	meta	meta	ADJ
ajlm-988	228	21	-	-	PUNCT
ajlm-988	228	22	analysis	analysis	NOUN
ajlm-988	228	23	.	.	PUNCT
ajlm-988	229	1	br	br	PROPN
ajlm-988	230	1	j	j	PROPN
ajlm-988	230	2	clin	clin	PROPN
ajlm-988	230	3	pharmacol	pharmacol	PROPN
ajlm-988	230	4	.	.	PUNCT
ajlm-988	231	1	2018;84(12):2747–2760	2018;84(12):2747–2760	X
ajlm-988	231	2	.	.	PUNCT
ajlm-988	232	1	https://doi.org/10.1111/bcp.13722	https://doi.org/10.1111/bcp.13722	PROPN
ajlm-988	232	2	podgorná	podgorná	NOUN
ajlm-988	232	3	e	e	NOUN
ajlm-988	232	4	,	,	PUNCT
ajlm-988	232	5	diallo	diallo	PROPN
ajlm-988	232	6	i	i	PRON
ajlm-988	232	7	,	,	PUNCT
ajlm-988	232	8	vangenot	vangenot	ADV
ajlm-988	232	9	c	c	X
ajlm-988	232	10	,	,	PUNCT
ajlm-988	232	11	et	et	PROPN
ajlm-988	232	12	al	al	PROPN
ajlm-988	232	13	.	.	PROPN
ajlm-988	232	14	variation	variation	NOUN
ajlm-988	232	15	in	in	ADP
ajlm-988	232	16	nat2	nat2	NOUN
ajlm-988	232	17	acetylation	acetylation	NOUN
ajlm-988	232	18	phenotypes	phenotype	NOUN
ajlm-988	232	19	is	be	AUX
ajlm-988	232	20	associated	associate	VERB
ajlm-988	232	21	with	with	ADP
ajlm-988	232	22	differences	difference	NOUN
ajlm-988	232	23	in	in	ADP
ajlm-988	232	24	food	food	NOUN
ajlm-988	232	25	-	-	PUNCT
ajlm-988	232	26	producing	produce	VERB
ajlm-988	232	27	subsistence	subsistence	NOUN
ajlm-988	232	28	modes	mode	NOUN
ajlm-988	232	29	and	and	CCONJ
ajlm-988	232	30	ecoregions	ecoregion	NOUN
ajlm-988	232	31	in	in	ADP
ajlm-988	232	32	africa	africa	PROPN
ajlm-988	232	33	.	.	PUNCT
ajlm-988	233	1	bmc	bmc	PROPN
ajlm-988	233	2	evol	evol	NOUN
ajlm-988	233	3	biol	biol	NOUN
ajlm-988	233	4	.	.	PUNCT
ajlm-988	234	1	2015;15(1):263	2015;15(1):263	ADV
ajlm-988	234	2	.	.	PUNCT
ajlm-988	235	1	https://doi.org/10.1186/s12862-015-0543-6	https://doi.org/10.1186/s12862-015-0543-6	PROPN
ajlm-988	235	2	patterson	patterson	PROPN
ajlm-988	235	3	n	n	PROPN
ajlm-988	235	4	,	,	PUNCT
ajlm-988	235	5	petersen	petersen	PROPN
ajlm-988	235	6	dc	dc	PROPN
ajlm-988	235	7	,	,	PUNCT
ajlm-988	235	8	van	van	PROPN
ajlm-988	235	9	der	der	PROPN
ajlm-988	235	10	ross	ross	PROPN
ajlm-988	235	11	re	re	PROPN
ajlm-988	235	12	,	,	PUNCT
ajlm-988	235	13	et	et	PROPN
ajlm-988	235	14	al	al	PROPN
ajlm-988	235	15	.	.	PUNCT
ajlm-988	236	1	genetic	genetic	ADJ
ajlm-988	236	2	structure	structure	NOUN
ajlm-988	236	3	of	of	ADP
ajlm-988	236	4	a	a	DET
ajlm-988	236	5	unique	unique	ADJ
ajlm-988	236	6	admixed	admix	VERB
ajlm-988	236	7	population	population	NOUN
ajlm-988	236	8	:	:	PUNCT
ajlm-988	236	9	implications	implication	NOUN
ajlm-988	236	10	for	for	ADP
ajlm-988	236	11	medical	medical	ADJ
ajlm-988	236	12	research	research	NOUN
ajlm-988	236	13	.	.	PUNCT
ajlm-988	237	1	hum	hum	PROPN
ajlm-988	237	2	mol	mol	ADP
ajlm-988	237	3	genet	genet	NOUN
ajlm-988	237	4	.	.	PUNCT
ajlm-988	238	1	2010;19(3):411–419	2010;19(3):411–419	NUM
ajlm-988	238	2	.	.	PUNCT
ajlm-988	239	1	https://doi.org/10.1093/hmg/ddp505	https://doi.org/10.1093/hmg/ddp505	PROPN
ajlm-988	239	2	de	de	PROPN
ajlm-988	239	3	wit	wit	PROPN
ajlm-988	239	4	e	e	PROPN
ajlm-988	239	5	,	,	PUNCT
ajlm-988	239	6	delport	delport	PROPN
ajlm-988	239	7	w	w	PROPN
ajlm-988	239	8	,	,	PUNCT
ajlm-988	239	9	rugamika	rugamika	PROPN
ajlm-988	239	10	ce	ce	PROPN
ajlm-988	239	11	,	,	PUNCT
ajlm-988	239	12	et	et	PROPN
ajlm-988	239	13	al	al	PROPN
ajlm-988	239	14	.	.	PUNCT
ajlm-988	239	15	genome	genome	NOUN
ajlm-988	239	16	-	-	PUNCT
ajlm-988	239	17	wide	wide	ADJ
ajlm-988	239	18	analysis	analysis	NOUN
ajlm-988	239	19	of	of	ADP
ajlm-988	239	20	the	the	DET
ajlm-988	239	21	structure	structure	NOUN
ajlm-988	239	22	of	of	ADP
ajlm-988	239	23	the	the	DET
ajlm-988	239	24	south	south	ADJ
ajlm-988	239	25	african	african	ADJ
ajlm-988	239	26	coloured	coloured	ADJ
ajlm-988	239	27	population	population	NOUN
ajlm-988	239	28	in	in	ADP
ajlm-988	239	29	the	the	DET
ajlm-988	239	30	western	western	ADJ
ajlm-988	239	31	cape	cape	NOUN
ajlm-988	239	32	.	.	PUNCT
ajlm-988	240	1	hum	hum	PROPN
ajlm-988	240	2	genet	genet	PROPN
ajlm-988	240	3	.	.	PUNCT
ajlm-988	241	1	2010;128(2):145–153	2010;128(2):145–153	X
ajlm-988	241	2	.	.	PUNCT
ajlm-988	241	3	https://doi.org/10.1007/s00439-010-0836-1	https://doi.org/10.1007/s00439-010-0836-1	NUM
ajlm-988	241	4	chimusa	chimusa	NOUN
ajlm-988	241	5	er	er	INTJ
ajlm-988	241	6	,	,	PUNCT
ajlm-988	241	7	zaitlen	zaitlen	PROPN
ajlm-988	241	8	n	n	CCONJ
ajlm-988	241	9	,	,	PUNCT
ajlm-988	241	10	daya	daya	PROPN
ajlm-988	241	11	m	m	PROPN
ajlm-988	241	12	,	,	PUNCT
ajlm-988	241	13	et	et	PROPN
ajlm-988	241	14	al	al	PROPN
ajlm-988	241	15	.	.	PUNCT
ajlm-988	241	16	genome	genome	NOUN
ajlm-988	241	17	-	-	PUNCT
ajlm-988	241	18	wide	wide	ADJ
ajlm-988	241	19	association	association	NOUN
ajlm-988	241	20	study	study	NOUN
ajlm-988	241	21	of	of	ADP
ajlm-988	241	22	ancestry	ancestry	NOUN
ajlm-988	241	23	-	-	PUNCT
ajlm-988	241	24	specific	specific	ADJ
ajlm-988	241	25	tb	tb	NOUN
ajlm-988	241	26	risk	risk	NOUN
ajlm-988	241	27	in	in	ADP
ajlm-988	241	28	the	the	DET
ajlm-988	241	29	south	south	ADJ
ajlm-988	241	30	african	african	ADJ
ajlm-988	241	31	coloured	coloured	ADJ
ajlm-988	241	32	population	population	NOUN
ajlm-988	241	33	.	.	PUNCT
ajlm-988	242	1	hum	hum	PROPN
ajlm-988	242	2	mol	mol	ADP
ajlm-988	242	3	genet	genet	NOUN
ajlm-988	242	4	.	.	PUNCT
ajlm-988	243	1	2014;23(3):796–809	2014;23(3):796–809	X
ajlm-988	243	2	.	.	PUNCT
ajlm-988	244	1	https://doi.org/10.1093/hmg/ddt462	https://doi.org/10.1093/hmg/ddt462	PROPN
ajlm-988	244	2	hall	hall	NOUN
ajlm-988	244	3	t.	t.	NOUN
ajlm-988	244	4	bioedit	bioedit	NOUN
ajlm-988	244	5	:	:	PUNCT
ajlm-988	244	6	a	a	DET
ajlm-988	244	7	user	user	NOUN
ajlm-988	244	8	-	-	PUNCT
ajlm-988	244	9	friendly	friendly	ADJ
ajlm-988	244	10	biological	biological	ADJ
ajlm-988	244	11	sequence	sequence	NOUN
ajlm-988	244	12	alignment	alignment	NOUN
ajlm-988	244	13	editor	editor	NOUN
ajlm-988	244	14	and	and	CCONJ
ajlm-988	244	15	analysis	analysis	NOUN
ajlm-988	244	16	program	program	NOUN
ajlm-988	244	17	for	for	ADP
ajlm-988	244	18	windows	window	NOUN
ajlm-988	244	19	95/98	95/98	NUM
ajlm-988	244	20	/	/	SYM
ajlm-988	244	21	nt	nt	NOUN
ajlm-988	244	22	.	.	PUNCT
ajlm-988	245	1	nucleic	nucleic	ADJ
ajlm-988	245	2	acids	acids	PROPN
ajlm-988	245	3	symp	symp	PROPN
ajlm-988	245	4	ser	ser	NOUN
ajlm-988	245	5	.	.	PUNCT
ajlm-988	246	1	1999;41:95–98	1999;41:95–98	NUM
ajlm-988	246	2	.	.	PUNCT
ajlm-988	247	1	tufts	tuft	NOUN
ajlm-988	247	2	university	university	PROPN
ajlm-988	247	3	.	.	PUNCT
ajlm-988	248	1	court	court	NOUN
ajlm-988	248	2	lab	lab	VERB
ajlm-988	248	3	hardy	hardy	ADJ
ajlm-988	248	4	-	-	PUNCT
ajlm-988	248	5	weinberg	weinberg	NOUN
ajlm-988	248	6	calculator	calculator	NOUN
ajlm-988	248	7	.	.	PUNCT
ajlm-988	249	1	n.d	n.d	PROPN
ajlm-988	249	2	.	.	PUNCT
ajlm-988	250	1	[	[	X
ajlm-988	250	2	accessed	access	VERB
ajlm-988	250	3	2020	2020	NUM
ajlm-988	250	4	aug	aug	PROPN
ajlm-988	250	5	14	14	NUM
ajlm-988	250	6	]	]	PUNCT
ajlm-988	250	7	.	.	PUNCT
ajlm-988	251	1	available	available	ADJ
ajlm-988	251	2	from	from	ADP
ajlm-988	251	3	:	:	PUNCT
ajlm-988	251	4	http://emerald.tufts.edu/~mcourt01/documents/court	http://emerald.tufts.edu/~mcourt01/documents/court	NOUN
ajlm-988	251	5	lab	lab	NOUN
ajlm-988	251	6	hw	hw	PROPN
ajlm-988	251	7	calculator.xls	calculator.xls	X
ajlm-988	251	8	matimba	matimba	NOUN
ajlm-988	251	9	a	a	DET
ajlm-988	251	10	,	,	PUNCT
ajlm-988	251	11	del	del	PROPN
ajlm-988	251	12	-	-	NOUN
ajlm-988	251	13	favero	favero	ADJ
ajlm-988	251	14	j	j	PROPN
ajlm-988	251	15	,	,	PUNCT
ajlm-988	251	16	van	van	PROPN
ajlm-988	251	17	broeckhoven	broeckhoven	NOUN
ajlm-988	251	18	c	c	PROPN
ajlm-988	251	19	,	,	PUNCT
ajlm-988	251	20	masimirembwa	masimirembwa	ADJ
ajlm-988	251	21	c.	c.	PROPN
ajlm-988	251	22	novel	novel	PROPN
ajlm-988	251	23	variants	variant	NOUN
ajlm-988	251	24	of	of	ADP
ajlm-988	251	25	major	major	ADJ
ajlm-988	251	26	drug	drug	NOUN
ajlm-988	251	27	-	-	PUNCT
ajlm-988	251	28	metabolising	metabolise	VERB
ajlm-988	251	29	enzyme	enzyme	NOUN
ajlm-988	251	30	genes	gene	NOUN
ajlm-988	251	31	in	in	ADP
ajlm-988	251	32	diverse	diverse	ADJ
ajlm-988	251	33	african	african	ADJ
ajlm-988	251	34	populations	population	NOUN
ajlm-988	251	35	and	and	CCONJ
ajlm-988	251	36	their	their	PRON
ajlm-988	251	37	predicted	predict	VERB
ajlm-988	251	38	functional	functional	ADJ
ajlm-988	251	39	effects	effect	NOUN
ajlm-988	251	40	.	.	PUNCT
ajlm-988	252	1	hum	hum	ADJ
ajlm-988	252	2	genomics	genomic	NOUN
ajlm-988	252	3	.	.	PUNCT
ajlm-988	253	1	2009;3(2):169–190	2009;3(2):169–190	NUM
ajlm-988	253	2	.	.	PUNCT
ajlm-988	254	1	https://doi.org/10.1186/1479-7364-3-2-169	https://doi.org/10.1186/1479-7364-3-2-169	PROPN
ajlm-988	254	2	national	national	ADJ
ajlm-988	254	3	centre	centre	NOUN
ajlm-988	254	4	for	for	ADP
ajlm-988	254	5	biotechnology	biotechnology	NOUN
ajlm-988	254	6	information	information	NOUN
ajlm-988	254	7	(	(	PUNCT
ajlm-988	254	8	ncbi	ncbi	NOUN
ajlm-988	254	9	)	)	PUNCT
ajlm-988	254	10	.	.	PUNCT
ajlm-988	255	1	database	database	NOUN
ajlm-988	255	2	of	of	ADP
ajlm-988	255	3	single	single	ADJ
ajlm-988	255	4	nucleotide	nucleotide	ADJ
ajlm-988	255	5	polymorphisms	polymorphism	NOUN
ajlm-988	255	6	(	(	PUNCT
ajlm-988	255	7	dbsnp	dbsnp	ADJ
ajlm-988	255	8	)	)	PUNCT
ajlm-988	255	9	.	.	PUNCT
ajlm-988	256	1	2020	2020	NUM
ajlm-988	257	1	[	[	X
ajlm-988	257	2	accessed	access	VERB
ajlm-988	257	3	2020	2020	NUM
ajlm-988	257	4	sep	sep	PROPN
ajlm-988	257	5	7	7	NUM
ajlm-988	257	6	]	]	PUNCT
ajlm-988	257	7	.	.	PUNCT
ajlm-988	258	1	available	available	ADJ
ajlm-988	258	2	from	from	ADP
ajlm-988	258	3	:	:	PUNCT
ajlm-988	258	4	https://www.ncbi.nlm.nih.gov/snp	https://www.ncbi.nlm.nih.gov/snp	PROPN
ajlm-988	258	5	fuselli	fuselli	PROPN
ajlm-988	258	6	s	s	PROPN
ajlm-988	258	7	,	,	PUNCT
ajlm-988	258	8	gilman	gilman	PROPN
ajlm-988	258	9	rh	rh	PROPN
ajlm-988	258	10	,	,	PUNCT
ajlm-988	258	11	chanock	chanock	NOUN
ajlm-988	258	12	sj	sj	PROPN
ajlm-988	258	13	,	,	PUNCT
ajlm-988	258	14	et	et	PROPN
ajlm-988	258	15	al	al	PROPN
ajlm-988	258	16	.	.	PUNCT
ajlm-988	259	1	analysis	analysis	NOUN
ajlm-988	259	2	of	of	ADP
ajlm-988	259	3	nucleotide	nucleotide	ADJ
ajlm-988	259	4	diversity	diversity	NOUN
ajlm-988	259	5	of	of	ADP
ajlm-988	259	6	nat2	nat2	PROPN
ajlm-988	259	7	coding	code	VERB
ajlm-988	259	8	region	region	NOUN
ajlm-988	259	9	reveals	reveal	VERB
ajlm-988	259	10	homogeneity	homogeneity	NOUN
ajlm-988	259	11	across	across	ADP
ajlm-988	259	12	native	native	ADJ
ajlm-988	259	13	american	american	ADJ
ajlm-988	259	14	populations	population	NOUN
ajlm-988	259	15	and	and	CCONJ
ajlm-988	259	16	high	high	ADJ
ajlm-988	259	17	intra	intra	ADJ
ajlm-988	259	18	-	-	ADJ
ajlm-988	259	19	population	population	ADJ
ajlm-988	259	20	diversity	diversity	NOUN
ajlm-988	259	21	.	.	PUNCT
ajlm-988	260	1	pharmacogenomics	pharmacogenomics	PROPN
ajlm-988	260	2	j.	j.	PROPN
ajlm-988	260	3	2007;7(2):144–152	2007;7(2):144–152	PROPN
ajlm-988	260	4	.	.	PUNCT
ajlm-988	261	1	https://doi.org/10.1038/sj.tpj.6500407	https://doi.org/10.1038/sj.tpj.6500407	NOUN
ajlm-988	261	2	sabbagh	sabbagh	VERB
ajlm-988	261	3	a	a	PRON
ajlm-988	261	4	,	,	PUNCT
ajlm-988	261	5	langaney	langaney	NOUN
ajlm-988	261	6	a	a	PRON
ajlm-988	261	7	,	,	PUNCT
ajlm-988	261	8	darlu	darlu	NOUN
ajlm-988	261	9	p	p	NOUN
ajlm-988	261	10	,	,	PUNCT
ajlm-988	261	11	gerard	gerard	PROPN
ajlm-988	261	12	n	n	CCONJ
ajlm-988	261	13	,	,	PUNCT
ajlm-988	261	14	krishnamoorthy	krishnamoorthy	ADJ
ajlm-988	261	15	r	r	NOUN
ajlm-988	261	16	,	,	PUNCT
ajlm-988	261	17	poloni	poloni	NOUN
ajlm-988	261	18	es	es	NOUN
ajlm-988	261	19	.	.	NOUN
ajlm-988	262	1	worldwide	worldwide	ADJ
ajlm-988	262	2	distribution	distribution	NOUN
ajlm-988	262	3	of	of	ADP
ajlm-988	262	4	nat2	nat2	NOUN
ajlm-988	262	5	diversity	diversity	NOUN
ajlm-988	262	6	:	:	PUNCT
ajlm-988	262	7	implications	implication	NOUN
ajlm-988	262	8	for	for	ADP
ajlm-988	262	9	nat2	nat2	NOUN
ajlm-988	262	10	evolutionary	evolutionary	ADJ
ajlm-988	262	11	history	history	NOUN
ajlm-988	262	12	.	.	PUNCT
ajlm-988	263	1	bmc	bmc	PROPN
ajlm-988	263	2	genet	genet	NOUN
ajlm-988	263	3	.	.	PUNCT
ajlm-988	264	1	2008;9(1):21	2008;9(1):21	X
ajlm-988	264	2	.	.	PUNCT
ajlm-988	265	1	https://doi.org/10.1186/1471-2156-9-21	https://doi.org/10.1186/1471-2156-9-21	PROPN
ajlm-988	265	2	loktionov	loktionov	PROPN
ajlm-988	265	3	a	a	X
ajlm-988	265	4	,	,	PUNCT
ajlm-988	265	5	moore	moore	PROPN
ajlm-988	265	6	w	w	PROPN
ajlm-988	265	7	,	,	PUNCT
ajlm-988	265	8	spencer	spencer	PROPN
ajlm-988	265	9	sp	sp	PROPN
ajlm-988	265	10	,	,	PUNCT
ajlm-988	265	11	et	et	PROPN
ajlm-988	265	12	al	al	PROPN
ajlm-988	265	13	.	.	PROPN
ajlm-988	265	14	differences	difference	NOUN
ajlm-988	265	15	in	in	ADP
ajlm-988	265	16	n	n	CCONJ
ajlm-988	265	17	-	-	PUNCT
ajlm-988	265	18	acetylation	acetylation	NOUN
ajlm-988	265	19	genotypes	genotype	NOUN
ajlm-988	265	20	between	between	ADP
ajlm-988	265	21	caucasians	caucasian	NOUN
ajlm-988	265	22	and	and	CCONJ
ajlm-988	265	23	black	black	ADJ
ajlm-988	265	24	south	south	PROPN
ajlm-988	265	25	africans	africans	PROPN
ajlm-988	265	26	:	:	PUNCT
ajlm-988	265	27	implications	implication	NOUN
ajlm-988	265	28	for	for	ADP
ajlm-988	265	29	cancer	cancer	NOUN
ajlm-988	265	30	prevention	prevention	NOUN
ajlm-988	265	31	.	.	PUNCT
ajlm-988	266	1	cancer	cancer	NOUN
ajlm-988	266	2	detect	detect	PROPN
ajlm-988	266	3	prev	prev	NOUN
ajlm-988	266	4	.	.	PUNCT
ajlm-988	267	1	2002;26(1):15–22	2002;26(1):15–22	NUM
ajlm-988	267	2	.	.	PUNCT
ajlm-988	268	1	https://doi.org/10.1016/s0361-090x(02)00010-7	https://doi.org/10.1016/s0361-090x(02)00010-7	ADJ
ajlm-988	268	2	centner	centner	NOUN
ajlm-988	268	3	cm	cm	PROPN
ajlm-988	268	4	,	,	PUNCT
ajlm-988	268	5	carrara	carrara	ADJ
ajlm-988	268	6	h	h	NOUN
ajlm-988	268	7	,	,	PUNCT
ajlm-988	268	8	harrison	harrison	PROPN
ajlm-988	268	9	t	t	PROPN
ajlm-988	268	10	,	,	PUNCT
ajlm-988	268	11	benatar	benatar	PROPN
ajlm-988	268	12	m	m	PROPN
ajlm-988	268	13	,	,	PUNCT
ajlm-988	268	14	heckmann	heckmann	PROPN
ajlm-988	268	15	j.	j.	PROPN
ajlm-988	268	16	sensory	sensory	ADJ
ajlm-988	268	17	polyneuropathy	polyneuropathy	NOUN
ajlm-988	268	18	in	in	ADP
ajlm-988	268	19	human	human	ADJ
ajlm-988	268	20	immunodeficiency	immunodeficiency	NOUN
ajlm-988	268	21	virus	virus	NOUN
ajlm-988	268	22	-	-	PUNCT
ajlm-988	268	23	infected	infect	VERB
ajlm-988	268	24	patients	patient	NOUN
ajlm-988	268	25	receiving	receive	VERB
ajlm-988	268	26	tuberculosis	tuberculosis	NOUN
ajlm-988	268	27	treatment	treatment	NOUN
ajlm-988	268	28	.	.	PUNCT
ajlm-988	269	1	int	int	PROPN
ajlm-988	269	2	j	j	PROPN
ajlm-988	269	3	tuberc	tuberc	PROPN
ajlm-988	269	4	lung	lung	PROPN
ajlm-988	269	5	dis	dis	PROPN
ajlm-988	269	6	.	.	PUNCT
ajlm-988	270	1	2014;18(1):27–33	2014;18(1):27–33	NOUN
ajlm-988	270	2	.	.	PUNCT
ajlm-988	271	1	https://doi.org/10.5588/ijtld.13.0375	https://doi.org/10.5588/ijtld.13.0375	PROPN
ajlm-988	271	2	golka	golka	PROPN
ajlm-988	271	3	k	k	PROPN
ajlm-988	271	4	,	,	PUNCT
ajlm-988	271	5	blaszkewicz	blaszkewicz	PROPN
ajlm-988	271	6	m	m	PROPN
ajlm-988	271	7	,	,	PUNCT
ajlm-988	271	8	samimi	samimi	PROPN
ajlm-988	271	9	m	m	PROPN
ajlm-988	271	10	,	,	PUNCT
ajlm-988	271	11	bolt	bolt	NOUN
ajlm-988	271	12	hm	hm	INTJ
ajlm-988	271	13	,	,	PUNCT
ajlm-988	271	14	selinski	selinski	PROPN
ajlm-988	271	15	s.	s.	PROPN
ajlm-988	271	16	reconstruction	reconstruction	NOUN
ajlm-988	271	17	of	of	ADP
ajlm-988	271	18	n	n	CCONJ
ajlm-988	271	19	-	-	PUNCT
ajlm-988	271	20	acetyltransferase	acetyltransferase	ADJ
ajlm-988	271	21	2	2	NUM
ajlm-988	271	22	haplotypes	haplotype	NOUN
ajlm-988	271	23	using	use	VERB
ajlm-988	271	24	phase	phase	NOUN
ajlm-988	271	25	.	.	PUNCT
ajlm-988	272	1	arch	arch	PROPN
ajlm-988	272	2	toxicol	toxicol	PROPN
ajlm-988	272	3	.	.	PUNCT
ajlm-988	273	1	2008;82(4):265–270	2008;82(4):265–270	NUM
ajlm-988	273	2	.	.	PUNCT
ajlm-988	273	3	https://doi.org/10.1007/s00204-007-0247-9	https://doi.org/10.1007/s00204-007-0247-9	PROPN
ajlm-988	273	4	pasipanodya	pasipanodya	PROPN
ajlm-988	273	5	jg	jg	PROPN
ajlm-988	273	6	,	,	PUNCT
ajlm-988	273	7	srivastava	srivastava	PROPN
ajlm-988	273	8	s	s	PROPN
ajlm-988	273	9	,	,	PUNCT
ajlm-988	273	10	gumbo	gumbo	NOUN
ajlm-988	273	11	t.	t.	PROPN
ajlm-988	273	12	meta	meta	NOUN
ajlm-988	273	13	-	-	PUNCT
ajlm-988	273	14	analysis	analysis	NOUN
ajlm-988	273	15	of	of	ADP
ajlm-988	273	16	clinical	clinical	ADJ
ajlm-988	273	17	studies	study	NOUN
ajlm-988	273	18	supports	support	VERB
ajlm-988	273	19	the	the	DET
ajlm-988	273	20	pharmacokinetic	pharmacokinetic	ADJ
ajlm-988	273	21	variability	variability	NOUN
ajlm-988	273	22	hypothesis	hypothesis	NOUN
ajlm-988	273	23	for	for	ADP
ajlm-988	273	24	acquired	acquire	VERB
ajlm-988	273	25	drug	drug	NOUN
ajlm-988	273	26	resistance	resistance	NOUN
ajlm-988	273	27	and	and	CCONJ
ajlm-988	273	28	failure	failure	NOUN
ajlm-988	273	29	of	of	ADP
ajlm-988	273	30	antituberculosis	antituberculosis	NOUN
ajlm-988	273	31	therapy	therapy	NOUN
ajlm-988	273	32	.	.	PUNCT
ajlm-988	274	1	clin	clin	PROPN
ajlm-988	274	2	infect	infect	PROPN
ajlm-988	274	3	dis	dis	PROPN
ajlm-988	274	4	.	.	PUNCT
ajlm-988	275	1	2012;55(2):169–177	2012;55(2):169–177	X
ajlm-988	275	2	.	.	X
ajlm-988	276	1	https://doi.org/10.1093/cid/cis353	https://doi.org/10.1093/cid/cis353	PROPN