id	sid	tid	token	lemma	pos
afs-72863	1	1	contribution	contribution	NOUN
afs-72863	1	2	of	of	ADP
afs-72863	1	3	modern	modern	ADJ
afs-72863	1	4	biotechnology	biotechnology	NOUN
afs-72863	1	5	of	of	ADP
afs-72863	1	6	lactic	lactic	ADJ
afs-72863	1	7	acid	acid	NOUN
afs-72863	1	8	bacteria	bacteria	NOUN
afs-72863	1	9	to	to	ADP
afs-72863	1	10	development	development	NOUN
afs-72863	1	11	of	of	ADP
afs-72863	1	12	health	health	NOUN
afs-72863	1	13	-	-	PUNCT
afs-72863	1	14	promoting	promote	VERB
afs-72863	1	15	foods	food	NOUN
afs-72863	1	16	airi	airi	PROPN
afs-72863	1	17	palva	palva	PROPN
afs-72863	1	18	agricultural	agricultural	ADJ
afs-72863	1	19	research	research	NOUN
afs-72863	1	20	centre	centre	PROPN
afs-72863	1	21	offinland	offinland	NOUN
afs-72863	1	22	,	,	PUNCT
afs-72863	1	23	food	food	NOUN
afs-72863	1	24	research	research	NOUN
afs-72863	1	25	,	,	PUNCT
afs-72863	1	26	fin-31600	fin-31600	NOUN
afs-72863	1	27	jokioinen	jokioinen	PROPN
afs-72863	1	28	,	,	PUNCT
afs-72863	1	29	finland	finland	PROPN
afs-72863	1	30	.	.	PUNCT
afs-72863	2	1	current	current	ADJ
afs-72863	2	2	address	address	NOUN
afs-72863	2	3	:	:	PUNCT
afs-72863	2	4	faculty	faculty	NOUN
afs-72863	2	5	of	of	ADP
afs-72863	2	6	veterinary	veterinary	ADJ
afs-72863	2	7	medicine	medicine	NOUN
afs-72863	2	8	,	,	PUNCT
afs-72863	2	9	hämeentie	hämeentie	NOUN
afs-72863	2	10	57	57	NUM
afs-72863	2	11	,	,	PUNCT
afs-72863	2	12	fin-00014	fin-00014	NOUN
afs-72863	2	13	university	university	NOUN
afs-72863	2	14	ofhelsinki	ofhelsinki	NOUN
afs-72863	2	15	,	,	PUNCT
afs-72863	2	16	finland	finland	PROPN
afs-72863	2	17	,	,	PUNCT
afs-72863	2	18	e	e	NOUN
afs-72863	2	19	-	-	NOUN
afs-72863	2	20	mail	mail	NOUN
afs-72863	2	21	:	:	PUNCT
afs-72863	2	22	airi.palva@helsinki.fi	airi.palva@helsinki.fi	ADJ
afs-72863	2	23	lactic	lactic	ADJ
afs-72863	2	24	acid	acid	NOUN
afs-72863	2	25	bacteria	bacteria	NOUN
afs-72863	2	26	(	(	PUNCT
afs-72863	2	27	lab	lab	NOUN
afs-72863	2	28	)	)	PUNCT
afs-72863	2	29	are	be	AUX
afs-72863	2	30	extensively	extensively	ADV
afs-72863	2	31	used	use	VERB
afs-72863	2	32	in	in	ADP
afs-72863	2	33	the	the	DET
afs-72863	2	34	manufacture	manufacture	NOUN
afs-72863	2	35	of	of	ADP
afs-72863	2	36	a	a	DET
afs-72863	2	37	wide	wide	ADJ
afs-72863	2	38	variety	variety	NOUN
afs-72863	2	39	of	of	ADP
afs-72863	2	40	fermented	ferment	VERB
afs-72863	2	41	dairy	dairy	NOUN
afs-72863	2	42	,	,	PUNCT
afs-72863	2	43	meat	meat	NOUN
afs-72863	2	44	,	,	PUNCT
afs-72863	2	45	vegetable	vegetable	NOUN
afs-72863	2	46	,	,	PUNCT
afs-72863	2	47	bakery	bakery	NOUN
afs-72863	2	48	and	and	CCONJ
afs-72863	2	49	wine	wine	NOUN
afs-72863	2	50	products	product	NOUN
afs-72863	2	51	in	in	ADP
afs-72863	2	52	the	the	DET
afs-72863	2	53	food	food	NOUN
afs-72863	2	54	and	and	CCONJ
afs-72863	2	55	wine	wine	NOUN
afs-72863	2	56	industry	industry	NOUN
afs-72863	2	57	as	as	ADV
afs-72863	2	58	well	well	ADV
afs-72863	2	59	as	as	ADP
afs-72863	2	60	in	in	ADP
afs-72863	2	61	making	make	VERB
afs-72863	2	62	silage	silage	NOUN
afs-72863	2	63	for	for	ADP
afs-72863	2	64	animal	animal	NOUN
afs-72863	2	65	feed	feed	NOUN
afs-72863	2	66	.	.	PUNCT
afs-72863	3	1	some	some	DET
afs-72863	3	2	lab	lab	NOUN
afs-72863	3	3	strains	strain	NOUN
afs-72863	3	4	also	also	ADV
afs-72863	3	5	have	have	VERB
afs-72863	3	6	an	an	DET
afs-72863	3	7	increasingly	increasingly	ADV
afs-72863	3	8	important	important	ADJ
afs-72863	3	9	role	role	NOUN
afs-72863	3	10	as	as	ADP
afs-72863	3	11	health	health	NOUN
afs-72863	3	12	-	-	PUNCT
afs-72863	3	13	promoting	promote	VERB
afs-72863	3	14	probiotics	probiotic	NOUN
afs-72863	3	15	.	.	PUNCT
afs-72863	4	1	molecular	molecular	ADJ
afs-72863	4	2	genetic	genetic	ADJ
afs-72863	4	3	research	research	NOUN
afs-72863	4	4	of	of	ADP
afs-72863	4	5	lab	lab	NOUN
afs-72863	4	6	,	,	PUNCT
afs-72863	4	7	focused	focus	VERB
afs-72863	4	8	mainly	mainly	ADV
afs-72863	4	9	on	on	ADP
afs-72863	4	10	the	the	DET
afs-72863	4	11	basic	basic	ADJ
afs-72863	4	12	characterisation	characterisation	NOUN
afs-72863	4	13	of	of	ADP
afs-72863	4	14	traits	trait	NOUN
afs-72863	4	15	essential	essential	ADJ
afs-72863	4	16	for	for	ADP
afs-72863	4	17	the	the	DET
afs-72863	4	18	industrial	industrial	ADJ
afs-72863	4	19	utilisation	utilisation	NOUN
afs-72863	4	20	of	of	ADP
afs-72863	4	21	these	these	DET
afs-72863	4	22	bacteria	bacteria	NOUN
afs-72863	4	23	,	,	PUNCT
afs-72863	4	24	forms	form	VERB
afs-72863	4	25	a	a	DET
afs-72863	4	26	solid	solid	ADJ
afs-72863	4	27	scientific	scientific	ADJ
afs-72863	4	28	basis	basis	NOUN
afs-72863	4	29	for	for	ADP
afs-72863	4	30	stabilisation	stabilisation	NOUN
afs-72863	4	31	,	,	PUNCT
afs-72863	4	32	modification	modification	NOUN
afs-72863	4	33	and	and	CCONJ
afs-72863	4	34	improvement	improvement	NOUN
afs-72863	4	35	of	of	ADP
afs-72863	4	36	these	these	DET
afs-72863	4	37	characteristics	characteristic	NOUN
afs-72863	4	38	.	.	PUNCT
afs-72863	5	1	the	the	DET
afs-72863	5	2	emphasis	emphasis	NOUN
afs-72863	5	3	of	of	ADP
afs-72863	5	4	this	this	DET
afs-72863	5	5	review	review	NOUN
afs-72863	5	6	is	be	AUX
afs-72863	5	7	on	on	ADP
afs-72863	5	8	the	the	DET
afs-72863	5	9	molecular	molecular	ADJ
afs-72863	5	10	genetic	genetic	ADJ
afs-72863	5	11	work	work	NOUN
afs-72863	5	12	done	do	VERB
afs-72863	5	13	at	at	ADP
afs-72863	5	14	the	the	DET
afs-72863	5	15	research	research	NOUN
afs-72863	5	16	laboratory	laboratory	NOUN
afs-72863	5	17	of	of	ADP
afs-72863	5	18	the	the	DET
afs-72863	5	19	author	author	NOUN
afs-72863	5	20	.	.	PUNCT
afs-72863	6	1	our	our	PRON
afs-72863	6	2	research	research	NOUN
afs-72863	6	3	team	team	NOUN
afs-72863	6	4	is	be	AUX
afs-72863	6	5	engaged	engage	VERB
afs-72863	6	6	on	on	ADP
afs-72863	6	7	,	,	PUNCT
afs-72863	6	8	two	two	NUM
afs-72863	6	9	main	main	ADJ
afs-72863	6	10	projects	project	NOUN
afs-72863	6	11	:	:	PUNCT
afs-72863	6	12	molecular	molecular	ADJ
afs-72863	6	13	genetic	genetic	ADJ
afs-72863	6	14	and	and	CCONJ
afs-72863	6	15	biochemical	biochemical	ADJ
afs-72863	6	16	characterisation	characterisation	NOUN
afs-72863	6	17	of	of	ADP
afs-72863	6	18	the	the	DET
afs-72863	6	19	proteolytic	proteolytic	ADJ
afs-72863	6	20	systems	system	NOUN
afs-72863	6	21	of	of	ADP
afs-72863	6	22	industrial	industrial	ADJ
afs-72863	6	23	thermophilic	thermophilic	ADJ
afs-72863	6	24	lactobacilli	lactobacilli	PROPN
afs-72863	6	25	and	and	CCONJ
afs-72863	6	26	surface	surface	NOUN
afs-72863	6	27	layer	layer	NOUN
afs-72863	6	28	protein	protein	NOUN
afs-72863	6	29	studies	study	NOUN
afs-72863	6	30	to	to	PART
afs-72863	6	31	develop	develop	VERB
afs-72863	6	32	protein	protein	NOUN
afs-72863	6	33	production	production	NOUN
afs-72863	6	34	systems	system	NOUN
afs-72863	6	35	for	for	ADP
afs-72863	6	36	food	food	NOUN
afs-72863	6	37	,	,	PUNCT
afs-72863	6	38	feed	feed	NOUN
afs-72863	6	39	,	,	PUNCT
afs-72863	6	40	vaccine	vaccine	NOUN
afs-72863	6	41	and	and	CCONJ
afs-72863	6	42	diagnostic	diagnostic	ADJ
afs-72863	6	43	purposes	purpose	NOUN
afs-72863	6	44	.	.	PUNCT
afs-72863	7	1	key	key	ADJ
afs-72863	7	2	words	word	NOUN
afs-72863	7	3	:	:	PUNCT
afs-72863	7	4	aminopeptidase	aminopeptidase	NOUN
afs-72863	7	5	n	n	SYM
afs-72863	7	6	,	,	PUNCT
afs-72863	7	7	b	b	X
afs-72863	7	8	-	-	PUNCT
afs-72863	7	9	glucuronidase	glucuronidase	ADJ
afs-72863	7	10	,	,	PUNCT
afs-72863	7	11	cheese	cheese	NOUN
afs-72863	7	12	ripening	ripening	NOUN
afs-72863	7	13	,	,	PUNCT
afs-72863	7	14	e.	e.	PROPN
afs-72863	7	15	coli	coli	PROPN
afs-72863	7	16	6	6	NUM
afs-72863	7	17	-	-	PUNCT
afs-72863	7	18	lactamase	lactamase	NOUN
afs-72863	7	19	,	,	PUNCT
afs-72863	7	20	in	in	ADP
afs-72863	7	21	vivo	vivo	ADJ
afs-72863	7	22	expression	expression	NOUN
afs-72863	7	23	of	of	ADP
afs-72863	7	24	slpa	slpa	ADJ
afs-72863	7	25	,	,	PUNCT
afs-72863	7	26	luciferase	luciferase	ADJ
afs-72863	7	27	,	,	PUNCT
afs-72863	7	28	oligopeptide	oligopeptide	NOUN
afs-72863	7	29	transport	transport	NOUN
afs-72863	7	30	system	system	NOUN
afs-72863	7	31	,	,	PUNCT
afs-72863	7	32	peptidases	peptidase	NOUN
afs-72863	7	33	,	,	PUNCT
afs-72863	7	34	protein	protein	NOUN
afs-72863	7	35	secretion	secretion	NOUN
afs-72863	7	36	ntroduction	ntroduction	NOUN
afs-72863	7	37	lactic	lactic	ADJ
afs-72863	7	38	acid	acid	NOUN
afs-72863	7	39	bacteria	bacteria	NOUN
afs-72863	7	40	(	(	PUNCT
afs-72863	7	41	lab	lab	NOUN
afs-72863	7	42	)	)	PUNCT
afs-72863	7	43	are	be	AUX
afs-72863	7	44	a	a	DET
afs-72863	7	45	diverse	diverse	ADJ
afs-72863	7	46	group	group	NOUN
afs-72863	7	47	of	of	ADP
afs-72863	7	48	micro	micro	NOUN
afs-72863	7	49	-	-	NOUN
afs-72863	7	50	organisms	organism	NOUN
afs-72863	7	51	inhabiting	inhabit	VERB
afs-72863	7	52	various	various	ADJ
afs-72863	7	53	ecological	ecological	ADJ
afs-72863	7	54	niches	niche	NOUN
afs-72863	7	55	,	,	PUNCT
afs-72863	7	56	from	from	ADP
afs-72863	7	57	plant	plant	NOUN
afs-72863	7	58	surfaces	surface	NOUN
afs-72863	7	59	to	to	ADP
afs-72863	7	60	the	the	DET
afs-72863	7	61	gastrointestinal	gastrointestinal	ADJ
afs-72863	7	62	,	,	PUNCT
afs-72863	7	63	genital	genital	ADJ
afs-72863	7	64	and	and	CCONJ
afs-72863	7	65	respiratory	respiratory	ADJ
afs-72863	7	66	tracts	tract	NOUN
afs-72863	7	67	ofman	ofman	NOUN
afs-72863	7	68	and	and	CCONJ
afs-72863	7	69	animals	animal	NOUN
afs-72863	7	70	(	(	PUNCT
afs-72863	7	71	de	de	X
afs-72863	7	72	vuyst	vuyst	NOUN
afs-72863	7	73	and	and	CCONJ
afs-72863	7	74	vandamme	vandamme	PROPN
afs-72863	7	75	1994	1994	NUM
afs-72863	7	76	,	,	PUNCT
afs-72863	7	77	wood	wood	NOUN
afs-72863	7	78	1992	1992	NUM
afs-72863	7	79	)	)	PUNCT
afs-72863	7	80	.	.	PUNCT
afs-72863	8	1	lab	lab	NOUN
afs-72863	8	2	are	be	AUX
afs-72863	8	3	also	also	ADV
afs-72863	8	4	widely	widely	ADV
afs-72863	8	5	used	use	VERB
afs-72863	8	6	as	as	ADP
afs-72863	8	7	starters	starter	NOUN
afs-72863	8	8	in	in	ADP
afs-72863	8	9	the	the	DET
afs-72863	8	10	manufacture	manufacture	NOUN
afs-72863	8	11	of	of	ADP
afs-72863	8	12	fermented	fermented	ADJ
afs-72863	8	13	foods	food	NOUN
afs-72863	8	14	,	,	PUNCT
afs-72863	8	15	beverages	beverage	NOUN
afs-72863	8	16	,	,	PUNCT
afs-72863	8	17	pickled	pickle	VERB
afs-72863	8	18	vegetables	vegetable	NOUN
afs-72863	8	19	and	and	CCONJ
afs-72863	8	20	silage	silage	NOUN
afs-72863	8	21	(	(	PUNCT
afs-72863	8	22	de	de	X
afs-72863	8	23	vuyst	vuyst	NOUN
afs-72863	8	24	and	and	CCONJ
afs-72863	8	25	vandamme	vandamme	NOUN
afs-72863	8	26	1994	1994	NUM
afs-72863	8	27	)	)	PUNCT
afs-72863	8	28	.	.	PUNCT
afs-72863	9	1	in	in	ADP
afs-72863	9	2	fermentation	fermentation	NOUN
afs-72863	9	3	,	,	PUNCT
afs-72863	9	4	several	several	ADJ
afs-72863	9	5	metabolic	metabolic	NOUN
afs-72863	9	6	properties	property	NOUN
afs-72863	9	7	of	of	ADP
afs-72863	9	8	lab	lab	NOUN
afs-72863	9	9	serve	serve	VERB
afs-72863	9	10	special	special	ADJ
afs-72863	9	11	functions	function	NOUN
afs-72863	9	12	with	with	ADP
afs-72863	9	13	a	a	DET
afs-72863	9	14	direct	direct	ADJ
afs-72863	9	15	or	or	CCONJ
afs-72863	9	16	indirect	indirect	ADJ
afs-72863	9	17	impact	impact	NOUN
afs-72863	9	18	on	on	ADP
afs-72863	9	19	food	food	NOUN
afs-72863	9	20	processes	process	NOUN
afs-72863	9	21	.	.	PUNCT
afs-72863	10	1	fermentation	fermentation	NOUN
afs-72863	10	2	allows	allow	VERB
afs-72863	10	3	the	the	DET
afs-72863	10	4	preservation	preservation	NOUN
afs-72863	10	5	of	of	ADP
afs-72863	10	6	food	food	NOUN
afs-72863	10	7	and	and	CCONJ
afs-72863	10	8	affects	affect	VERB
afs-72863	10	9	the	the	DET
afs-72863	10	10	development	development	NOUN
afs-72863	10	11	of	of	ADP
afs-72863	10	12	flavour	flavour	NOUN
afs-72863	10	13	and	and	CCONJ
afs-72863	10	14	texture	texture	ADJ
afs-72863	10	15	,	,	PUNCT
afs-72863	10	16	whilst	whilst	ADV
afs-72863	10	17	,	,	PUNCT
afs-72863	10	18	starter	starter	ADJ
afs-72863	10	19	cultures	culture	NOUN
afs-72863	10	20	bring	bring	VERB
afs-72863	10	21	about	about	ADP
afs-72863	10	22	a	a	DET
afs-72863	10	23	variety	variety	NOUN
afs-72863	10	24	of	of	ADP
afs-72863	10	25	beneficial	beneficial	ADJ
afs-72863	10	26	metabolic	metabolic	NOUN
afs-72863	10	27	and	and	CCONJ
afs-72863	10	28	sensory	sensory	ADJ
afs-72863	10	29	changes	change	NOUN
afs-72863	10	30	in	in	ADP
afs-72863	10	31	food	food	NOUN
afs-72863	10	32	(	(	PUNCT
afs-72863	10	33	lindgren	lindgren	PROPN
afs-72863	10	34	and	and	CCONJ
afs-72863	10	35	dobrogosz	dobrogosz	NOUN
afs-72863	10	36	1990	1990	NUM
afs-72863	10	37	,	,	PUNCT
afs-72863	10	38	olson	olson	NOUN
afs-72863	10	39	1990	1990	NUM
afs-72863	10	40	,	,	PUNCT
afs-72863	10	41	holzapfel	holzapfel	NOUN
afs-72863	10	42	et	et	PROPN
afs-72863	10	43	al	al	PROPN
afs-72863	10	44	.	.	PROPN
afs-72863	10	45	1995	1995	NUM
afs-72863	10	46	)	)	PUNCT
afs-72863	10	47	.	.	PUNCT
afs-72863	11	1	some	some	DET
afs-72863	11	2	milk	milk	NOUN
afs-72863	11	3	products	product	NOUN
afs-72863	11	4	fermented	ferment	VERB
afs-72863	11	5	with	with	ADP
afs-72863	11	6	probiotic	probiotic	ADJ
afs-72863	11	7	lab	lab	NOUN
afs-72863	11	8	may	may	AUX
afs-72863	11	9	also	also	ADV
afs-72863	11	10	have	have	VERB
afs-72863	11	11	health	health	NOUN
afs-72863	11	12	and	and	CCONJ
afs-72863	11	13	additional	additional	ADJ
afs-72863	11	14	nutritional	nutritional	ADJ
afs-72863	11	15	benefits	benefit	NOUN
afs-72863	11	16	,	,	PUNCT
afs-72863	11	17	and	and	CCONJ
afs-72863	11	18	these	these	PRON
afs-72863	11	19	are	be	AUX
afs-72863	11	20	increasingly	increasingly	ADV
afs-72863	11	21	being	be	AUX
afs-72863	11	22	subjected	subject	VERB
afs-72863	11	23	to	to	ADP
afs-72863	11	24	r+d	r+d	PROPN
afs-72863	11	25	(	(	PUNCT
afs-72863	11	26	jensen	jensen	PROPN
afs-72863	11	27	1995,wood	1995,wood	NUM
afs-72863	11	28	1992	1992	NUM
afs-72863	11	29	)	)	PUNCT
afs-72863	11	30	.	.	PUNCT
afs-72863	12	1	the	the	DET
afs-72863	12	2	proposed	propose	VERB
afs-72863	12	3	key	key	ADJ
afs-72863	12	4	targets	target	NOUN
afs-72863	12	5	of	of	ADP
afs-72863	12	6	the	the	DET
afs-72863	12	7	health	health	NOUN
afs-72863	12	8	-	-	PUNCT
afs-72863	12	9	promoting	promote	VERB
afs-72863	12	10	effects	effect	NOUN
afs-72863	12	11	of	of	ADP
afs-72863	12	12	probiotic	probiotic	ADJ
afs-72863	12	13	lab	lab	NOUN
afs-72863	12	14	are	be	AUX
afs-72863	12	15	the	the	DET
afs-72863	12	16	prevention	prevention	NOUN
afs-72863	12	17	of	of	ADP
afs-72863	12	18	intestinal	intestinal	ADJ
afs-72863	12	19	infections	infection	NOUN
afs-72863	12	20	,	,	PUNCT
afs-72863	12	21	diar	diar	NOUN
afs-72863	12	22	©	©	PROPN
afs-72863	12	23	agricultural	agricultural	ADJ
afs-72863	12	24	and	and	CCONJ
afs-72863	12	25	food	food	NOUN
afs-72863	12	26	science	science	NOUN
afs-72863	12	27	in	in	ADP
afs-72863	12	28	finland	finland	PROPN
afs-72863	12	29	manuscript	manuscript	NOUN
afs-72863	12	30	received	receive	VERB
afs-72863	12	31	december	december	PROPN
afs-72863	12	32	1997	1997	NUM
afs-72863	12	33	267	267	NUM
afs-72863	12	34	voi	voi	NUM
afs-72863	12	35	7	7	NUM
afs-72863	12	36	(	(	PUNCT
afs-72863	12	37	1998	1998	NUM
afs-72863	12	38	v	v	ADP
afs-72863	12	39	267	267	NUM
afs-72863	12	40	-	-	SYM
afs-72863	12	41	282	282	NUM
afs-72863	12	42	.	.	PUNCT
afs-72863	12	43	agricultural	agricultural	ADJ
afs-72863	12	44	and	and	CCONJ
afs-72863	12	45	food	food	NOUN
afs-72863	12	46	science	science	NOUN
afs-72863	12	47	in	in	ADP
afs-72863	12	48	finland	finland	PROPN
afs-72863	12	49	rhoeal	rhoeal	NOUN
afs-72863	12	50	diseases	disease	NOUN
afs-72863	12	51	and	and	CCONJ
afs-72863	12	52	upper	upper	ADJ
afs-72863	12	53	gastrointestinal	gastrointestinal	ADJ
afs-72863	12	54	tract	tract	NOUN
afs-72863	12	55	diseases	disease	NOUN
afs-72863	12	56	,	,	PUNCT
afs-72863	12	57	the	the	DET
afs-72863	12	58	prevention	prevention	NOUN
afs-72863	12	59	of	of	ADP
afs-72863	12	60	cancer	cancer	NOUN
afs-72863	12	61	and	and	CCONJ
afs-72863	12	62	the	the	DET
afs-72863	12	63	hypercholesterolemia	hypercholesterolemia	NOUN
afs-72863	12	64	,	,	PUNCT
afs-72863	12	65	the	the	DET
afs-72863	12	66	improvement	improvement	NOUN
afs-72863	12	67	of	of	ADP
afs-72863	12	68	lactose	lactose	ADJ
afs-72863	12	69	utilisation	utilisation	NOUN
afs-72863	12	70	and	and	CCONJ
afs-72863	12	71	the	the	DET
afs-72863	12	72	stabilisation	stabilisation	NOUN
afs-72863	12	73	of	of	ADP
afs-72863	12	74	the	the	DET
afs-72863	12	75	gut	gut	NOUN
afs-72863	12	76	mucosal	mucosal	NOUN
afs-72863	12	77	barrier	barrier	NOUN
afs-72863	12	78	(	(	PUNCT
afs-72863	12	79	kailasapathy	kailasapathy	ADJ
afs-72863	12	80	and	and	CCONJ
afs-72863	12	81	rybka	rybka	PROPN
afs-72863	12	82	1997	1997	NUM
afs-72863	12	83	,	,	PUNCT
afs-72863	12	84	wood	wood	NOUN
afs-72863	12	85	1992	1992	NUM
afs-72863	12	86	,	,	PUNCT
afs-72863	12	87	salminen	salminen	PROPN
afs-72863	12	88	et	et	PROPN
afs-72863	12	89	al	al	PROPN
afs-72863	12	90	.	.	PROPN
afs-72863	12	91	1996	1996	NUM
afs-72863	12	92	)	)	PUNCT
afs-72863	12	93	.	.	PUNCT
afs-72863	13	1	the	the	DET
afs-72863	13	2	loosely	loosely	ADV
afs-72863	13	3	defined	define	VERB
afs-72863	13	4	group	group	NOUN
afs-72863	13	5	of	of	ADP
afs-72863	13	6	lab	lab	NOUN
afs-72863	13	7	includes	include	VERB
afs-72863	13	8	gram	gram	NOUN
afs-72863	13	9	-	-	PUNCT
afs-72863	13	10	positiverods	positiverod	NOUN
afs-72863	13	11	and	and	CCONJ
afs-72863	13	12	cocci	cocci	NOUN
afs-72863	13	13	with	with	ADP
afs-72863	13	14	low	low	ADJ
afs-72863	13	15	g+c	g+c	ADJ
afs-72863	13	16	content	content	NOUN
afs-72863	13	17	<	<	X
afs-72863	13	18	50	50	NUM
afs-72863	13	19	mol%	mol%	NOUN
afs-72863	13	20	(	(	PUNCT
afs-72863	13	21	pot	pot	NOUN
afs-72863	13	22	et	et	PROPN
afs-72863	13	23	al	al	PROPN
afs-72863	13	24	.	.	PROPN
afs-72863	13	25	1994	1994	NUM
afs-72863	13	26	)	)	PUNCT
afs-72863	13	27	.	.	PUNCT
afs-72863	14	1	lab	lab	NOUN
afs-72863	14	2	are	be	AUX
afs-72863	14	3	catalase	catalase	NOUN
afs-72863	14	4	negative	negative	ADJ
afs-72863	14	5	,	,	PUNCT
afs-72863	14	6	non	non	ADJ
afs-72863	14	7	-	-	ADJ
afs-72863	14	8	sporulating	sporulating	ADJ
afs-72863	14	9	(	(	PUNCT
afs-72863	14	10	except	except	SCONJ
afs-72863	14	11	sporolactobacillus	sporolactobacillus	ADJ
afs-72863	14	12	)	)	PUNCT
afs-72863	14	13	,	,	PUNCT
afs-72863	14	14	acidand	acidand	ADJ
afs-72863	14	15	aerotolerant	aerotolerant	VERB
afs-72863	14	16	anaerobic	anaerobic	NOUN
afs-72863	14	17	bacteria	bacteria	NOUN
afs-72863	14	18	that	that	PRON
afs-72863	14	19	produce	produce	VERB
afs-72863	14	20	lactic	lactic	ADJ
afs-72863	14	21	acid	acid	NOUN
afs-72863	14	22	as	as	ADP
afs-72863	14	23	a	a	DET
afs-72863	14	24	major	major	ADJ
afs-72863	14	25	or	or	CCONJ
afs-72863	14	26	sole	sole	ADJ
afs-72863	14	27	end	end	NOUN
afs-72863	14	28	-	-	PUNCT
afs-72863	14	29	product	product	NOUN
afs-72863	14	30	of	of	ADP
afs-72863	14	31	obligative	obligative	ADJ
afs-72863	14	32	fermentative	fermentative	ADJ
afs-72863	14	33	metabolism	metabolism	NOUN
afs-72863	14	34	(	(	PUNCT
afs-72863	14	35	pot	pot	NOUN
afs-72863	14	36	et	et	PROPN
afs-72863	14	37	al	al	PROPN
afs-72863	14	38	.	.	PROPN
afs-72863	14	39	1994	1994	NUM
afs-72863	14	40	,	,	PUNCT
afs-72863	14	41	wood	wood	NOUN
afs-72863	14	42	and	and	CCONJ
afs-72863	14	43	holzapfel	holzapfel	NOUN
afs-72863	14	44	1995	1995	NUM
afs-72863	14	45	)	)	PUNCT
afs-72863	14	46	.	.	PUNCT
afs-72863	15	1	taxonomically	taxonomically	ADV
afs-72863	15	2	lab	lab	NOUN
afs-72863	15	3	have	have	AUX
afs-72863	15	4	been	be	AUX
afs-72863	15	5	included	include	VERB
afs-72863	15	6	in	in	ADP
afs-72863	15	7	the	the	DET
afs-72863	15	8	genera	genera	NOUN
afs-72863	15	9	lactobacillus	lactobacillus	NOUN
afs-72863	15	10	,	,	PUNCT
afs-72863	15	11	lactococcus	lactococcus	PROPN
afs-72863	15	12	,	,	PUNCT
afs-72863	15	13	leuconostoc	leuconostoc	ADJ
afs-72863	15	14	,	,	PUNCT
afs-72863	15	15	pediococcus	pediococcus	ADJ
afs-72863	15	16	,	,	PUNCT
afs-72863	15	17	carnobacterium	carnobacterium	NOUN
afs-72863	15	18	,	,	PUNCT
afs-72863	15	19	sporolactobacillus	sporolactobacillus	ADJ
afs-72863	15	20	,	,	PUNCT
afs-72863	15	21	streptococcus	streptococcus	NOUN
afs-72863	15	22	,	,	PUNCT
afs-72863	15	23	enterococcus	enterococcus	NOUN
afs-72863	15	24	,	,	PUNCT
afs-72863	15	25	aerococcus	aerococcus	NOUN
afs-72863	15	26	,	,	PUNCT
afs-72863	15	27	vagococcus	vagococcus	NOUN
afs-72863	15	28	,	,	PUNCT
afs-72863	15	29	tetragenococcus	tetragenococcus	PROPN
afs-72863	15	30	and	and	CCONJ
afs-72863	15	31	atopium	atopium	NOUN
afs-72863	15	32	(	(	PUNCT
afs-72863	15	33	pot	pot	NOUN
afs-72863	15	34	et	et	PROPN
afs-72863	15	35	al	al	PROPN
afs-72863	15	36	.	.	PROPN
afs-72863	15	37	1994	1994	NUM
afs-72863	15	38	,	,	PUNCT
afs-72863	15	39	wood	wood	NOUN
afs-72863	15	40	and	and	CCONJ
afs-72863	15	41	holzapfel	holzapfel	NOUN
afs-72863	15	42	1995	1995	NUM
afs-72863	15	43	)	)	PUNCT
afs-72863	15	44	;	;	PUNCT
afs-72863	15	45	this	this	DET
afs-72863	15	46	classification	classification	NOUN
afs-72863	15	47	is	be	AUX
afs-72863	15	48	,	,	PUNCT
afs-72863	15	49	however	however	ADV
afs-72863	15	50	,	,	PUNCT
afs-72863	15	51	not	not	PART
afs-72863	15	52	final	final	ADJ
afs-72863	15	53	.	.	PUNCT
afs-72863	16	1	many	many	ADJ
afs-72863	16	2	characteristics	characteristic	NOUN
afs-72863	16	3	typical	typical	ADJ
afs-72863	16	4	of	of	ADP
afs-72863	16	5	genuine	genuine	ADJ
afs-72863	16	6	lab	lab	NOUN
afs-72863	16	7	are	be	AUX
afs-72863	16	8	also	also	ADV
afs-72863	16	9	sharedby	sharedby	VERB
afs-72863	16	10	the	the	DET
afs-72863	16	11	genus	genus	NOUN
afs-72863	16	12	bifidobacterium	bifidobacterium	NOUN
afs-72863	16	13	,	,	PUNCT
afs-72863	16	14	which	which	PRON
afs-72863	16	15	consists	consist	VERB
afs-72863	16	16	of	of	ADP
afs-72863	16	17	increasingly	increasingly	ADV
afs-72863	16	18	important	important	ADJ
afs-72863	16	19	health	health	NOUN
afs-72863	16	20	-	-	PUNCT
afs-72863	16	21	promoting	promote	VERB
afs-72863	16	22	intestinal	intestinal	ADJ
afs-72863	16	23	bacteria	bacteria	NOUN
afs-72863	16	24	(	(	PUNCT
afs-72863	16	25	kailasapathy	kailasapathy	ADJ
afs-72863	16	26	and	and	CCONJ
afs-72863	16	27	rybka	rybka	PROPN
afs-72863	16	28	1997	1997	NUM
afs-72863	16	29	)	)	PUNCT
afs-72863	16	30	.	.	PUNCT
afs-72863	17	1	bifidobacterium	bifidobacterium	NOUN
afs-72863	17	2	was	be	AUX
afs-72863	17	3	considered	consider	VERB
afs-72863	17	4	to	to	PART
afs-72863	17	5	be	be	AUX
afs-72863	17	6	one	one	NUM
afs-72863	17	7	of	of	ADP
afs-72863	17	8	the	the	DET
afs-72863	17	9	lab	lab	NOUN
afs-72863	17	10	,	,	PUNCT
afs-72863	17	11	but	but	CCONJ
afs-72863	17	12	due	due	ADP
afs-72863	17	13	to	to	ADP
afs-72863	17	14	their	their	PRON
afs-72863	17	15	high	high	ADJ
afs-72863	17	16	g+c	g+c	ADJ
afs-72863	17	17	content	content	NOUN
afs-72863	17	18	(	(	PUNCT
afs-72863	17	19	55	55	NUM
afs-72863	17	20	-	-	SYM
afs-72863	17	21	67	67	NUM
afs-72863	17	22	mol%	mol%	PROPN
afs-72863	17	23	)	)	PUNCT
afs-72863	17	24	and	and	CCONJ
afs-72863	17	25	on	on	ADP
afs-72863	17	26	the	the	DET
afs-72863	17	27	basis	basis	NOUN
afs-72863	17	28	of	of	ADP
afs-72863	17	29	16s	16s	PROPN
afs-72863	17	30	rrna	rrna	PROPN
afs-72863	17	31	data	data	PROPN
afs-72863	17	32	,	,	PUNCT
afs-72863	17	33	it	it	PRON
afs-72863	17	34	is	be	AUX
afs-72863	17	35	now	now	ADV
afs-72863	17	36	clear	clear	ADJ
afs-72863	17	37	that	that	SCONJ
afs-72863	17	38	the	the	DET
afs-72863	17	39	bifidobacteria	bifidobacteria	NOUN
afs-72863	17	40	belong	belong	VERB
afs-72863	17	41	to	to	ADP
afs-72863	17	42	the	the	DET
afs-72863	17	43	actinomyces	actinomyce	NOUN
afs-72863	17	44	branch	branch	NOUN
afs-72863	17	45	in	in	ADP
afs-72863	17	46	the	the	DET
afs-72863	17	47	phylogenetic	phylogenetic	ADJ
afs-72863	17	48	trees	tree	NOUN
afs-72863	17	49	ofgram	ofgram	ADJ
afs-72863	17	50	-	-	PUNCT
afs-72863	17	51	positive	positive	ADJ
afs-72863	17	52	bacteria	bacteria	NOUN
afs-72863	17	53	(	(	PUNCT
afs-72863	17	54	schleifer	schleifer	VERB
afs-72863	17	55	and	and	CCONJ
afs-72863	17	56	ludwig	ludwig	PROPN
afs-72863	17	57	1995	1995	NUM
afs-72863	17	58	)	)	PUNCT
afs-72863	17	59	.	.	PUNCT
afs-72863	18	1	owing	owe	VERB
afs-72863	18	2	to	to	ADP
afs-72863	18	3	the	the	DET
afs-72863	18	4	great	great	ADJ
afs-72863	18	5	diversity	diversity	NOUN
afs-72863	18	6	of	of	ADP
afs-72863	18	7	lab	lab	NOUN
afs-72863	18	8	,	,	PUNCT
afs-72863	18	9	especially	especially	ADV
afs-72863	18	10	among	among	ADP
afs-72863	18	11	one	one	NUM
afs-72863	18	12	of	of	ADP
afs-72863	18	13	the	the	DET
afs-72863	18	14	most	most	ADV
afs-72863	18	15	widely	widely	ADV
afs-72863	18	16	used	use	VERB
afs-72863	18	17	groups	group	NOUN
afs-72863	18	18	,	,	PUNCT
afs-72863	18	19	i.e.	i.e.	X
afs-72863	18	20	lactobacillus	lactobacillus	NOUN
afs-72863	18	21	,	,	PUNCT
afs-72863	18	22	molecular	molecular	ADJ
afs-72863	18	23	genetic	genetic	ADJ
afs-72863	18	24	studies	study	NOUN
afs-72863	18	25	of	of	ADP
afs-72863	18	26	lab	lab	NOUN
afs-72863	18	27	are	be	AUX
afs-72863	18	28	very	very	ADV
afs-72863	18	29	demanding	demanding	ADJ
afs-72863	18	30	.	.	PUNCT
afs-72863	19	1	however	however	ADV
afs-72863	19	2	,	,	PUNCT
afs-72863	19	3	since	since	SCONJ
afs-72863	19	4	being	be	AUX
afs-72863	19	5	of	of	ADP
afs-72863	19	6	such	such	ADJ
afs-72863	19	7	importance	importance	NOUN
afs-72863	19	8	in	in	ADP
afs-72863	19	9	the	the	DET
afs-72863	19	10	food	food	NOUN
afs-72863	19	11	industry	industry	NOUN
afs-72863	19	12	,	,	PUNCT
afs-72863	19	13	lab	lab	NOUN
afs-72863	19	14	,	,	PUNCT
afs-72863	19	15	particularly	particularly	ADV
afs-72863	19	16	the	the	DET
afs-72863	19	17	starters	starter	NOUN
afs-72863	19	18	used	use	VERB
afs-72863	19	19	in	in	ADP
afs-72863	19	20	the	the	DET
afs-72863	19	21	dairy	dairy	NOUN
afs-72863	19	22	products	product	NOUN
afs-72863	19	23	,	,	PUNCT
afs-72863	19	24	have	have	AUX
afs-72863	19	25	been	be	AUX
afs-72863	19	26	subjected	subject	VERB
afs-72863	19	27	to	to	ADP
afs-72863	19	28	extensive	extensive	ADJ
afs-72863	19	29	molecular	molecular	ADJ
afs-72863	19	30	genetic	genetic	ADJ
afs-72863	19	31	research	research	NOUN
afs-72863	19	32	for	for	ADP
afs-72863	19	33	many	many	ADJ
afs-72863	19	34	years	year	NOUN
afs-72863	19	35	.	.	PUNCT
afs-72863	20	1	the	the	DET
afs-72863	20	2	objectives	objective	NOUN
afs-72863	20	3	of	of	ADP
afs-72863	20	4	that	that	DET
afs-72863	20	5	research	research	NOUN
afs-72863	20	6	have	have	AUX
afs-72863	20	7	been	be	AUX
afs-72863	20	8	to	to	PART
afs-72863	20	9	characterise	characterise	VERB
afs-72863	20	10	,	,	PUNCT
afs-72863	20	11	stabilise	stabilise	VERB
afs-72863	20	12	and	and	CCONJ
afs-72863	20	13	improve	improve	VERB
afs-72863	20	14	traits	trait	NOUN
afs-72863	20	15	essential	essential	ADJ
afs-72863	20	16	for	for	ADP
afs-72863	20	17	food	food	NOUN
afs-72863	20	18	processes	process	NOUN
afs-72863	20	19	(	(	PUNCT
afs-72863	20	20	for	for	ADP
afs-72863	20	21	recent	recent	ADJ
afs-72863	20	22	reviews	review	NOUN
afs-72863	20	23	,	,	PUNCT
afs-72863	20	24	see	see	VERB
afs-72863	20	25	de	de	X
afs-72863	20	26	vos	vos	X
afs-72863	20	27	et	et	PROPN
afs-72863	20	28	al	al	PROPN
afs-72863	20	29	.	.	PROPN
afs-72863	20	30	1993	1993	NUM
afs-72863	20	31	,	,	PUNCT
afs-72863	20	32	venema	venema	NOUN
afs-72863	20	33	et	et	PROPN
afs-72863	20	34	al	al	PROPN
afs-72863	20	35	.	.	PROPN
afs-72863	20	36	1996	1996	NUM
afs-72863	20	37	)	)	PUNCT
afs-72863	20	38	.	.	PUNCT
afs-72863	21	1	much	much	ADJ
afs-72863	21	2	is	be	AUX
afs-72863	21	3	already	already	ADV
afs-72863	21	4	known	know	VERB
afs-72863	21	5	about	about	ADP
afs-72863	21	6	the	the	DET
afs-72863	21	7	molecular	molecular	ADJ
afs-72863	21	8	biology	biology	NOUN
afs-72863	21	9	of	of	ADP
afs-72863	21	10	starter	starter	ADJ
afs-72863	21	11	lactococci	lactococci	NOUN
afs-72863	21	12	but	but	CCONJ
afs-72863	21	13	during	during	ADP
afs-72863	21	14	the	the	DET
afs-72863	21	15	last	last	ADJ
afs-72863	21	16	few	few	ADJ
afs-72863	21	17	years	year	NOUN
afs-72863	21	18	,	,	PUNCT
afs-72863	21	19	a	a	DET
afs-72863	21	20	considerable	considerable	ADJ
afs-72863	21	21	amount	amount	NOUN
afs-72863	21	22	of	of	ADP
afs-72863	21	23	information	information	NOUN
afs-72863	21	24	has	have	AUX
afs-72863	21	25	also	also	ADV
afs-72863	21	26	been	be	AUX
afs-72863	21	27	gathered	gather	VERB
afs-72863	21	28	on	on	ADP
afs-72863	21	29	the	the	DET
afs-72863	21	30	various	various	ADJ
afs-72863	21	31	lactobacillar	lactobacillar	ADJ
afs-72863	21	32	species	specie	NOUN
afs-72863	21	33	.	.	PUNCT
afs-72863	22	1	in	in	ADP
afs-72863	22	2	addition	addition	NOUN
afs-72863	22	3	to	to	ADP
afs-72863	22	4	the	the	DET
afs-72863	22	5	development	development	NOUN
afs-72863	22	6	of	of	ADP
afs-72863	22	7	genetic	genetic	ADJ
afs-72863	22	8	tools	tool	NOUN
afs-72863	22	9	,	,	PUNCT
afs-72863	22	10	the	the	DET
afs-72863	22	11	main	main	ADJ
afs-72863	22	12	research	research	NOUN
afs-72863	22	13	targets	target	NOUN
afs-72863	22	14	have	have	AUX
afs-72863	22	15	been	be	AUX
afs-72863	22	16	characterisation	characterisation	NOUN
afs-72863	22	17	of	of	ADP
afs-72863	22	18	the	the	DET
afs-72863	22	19	key	key	ADJ
afs-72863	22	20	metabolic	metabolic	NOUN
afs-72863	22	21	genes	gene	NOUN
afs-72863	22	22	(	(	PUNCT
afs-72863	22	23	e.g.	e.g.	ADV
afs-72863	22	24	lactose	lactose	NOUN
afs-72863	22	25	and	and	CCONJ
afs-72863	22	26	citrate	citrate	NOUN
afs-72863	22	27	utilisation	utilisation	NOUN
afs-72863	22	28	,	,	PUNCT
afs-72863	22	29	proteolytic	proteolytic	ADJ
afs-72863	22	30	enzymes	enzyme	NOUN
afs-72863	22	31	)	)	PUNCT
afs-72863	22	32	and	and	CCONJ
afs-72863	22	33	metabolic	metabolic	NOUN
afs-72863	22	34	engineering	engineering	NOUN
afs-72863	22	35	,	,	PUNCT
afs-72863	22	36	isolation	isolation	NOUN
afs-72863	22	37	,	,	PUNCT
afs-72863	22	38	characterisation	characterisation	NOUN
afs-72863	22	39	and	and	CCONJ
afs-72863	22	40	modification	modification	NOUN
afs-72863	22	41	of	of	ADP
afs-72863	22	42	antimicrobials	antimicrobial	NOUN
afs-72863	22	43	for	for	ADP
afs-72863	22	44	food	food	NOUN
afs-72863	22	45	preservation	preservation	NOUN
afs-72863	22	46	,	,	PUNCT
afs-72863	22	47	bacteriophages	bacteriophage	NOUN
afs-72863	22	48	and	and	CCONJ
afs-72863	22	49	bacteriophage	bacteriophage	NOUN
afs-72863	22	50	resistance	resistance	NOUN
afs-72863	22	51	,	,	PUNCT
afs-72863	22	52	and	and	CCONJ
afs-72863	22	53	its	its	PRON
afs-72863	22	54	gene	gene	NOUN
afs-72863	22	55	expression	expression	NOUN
afs-72863	22	56	and	and	CCONJ
afs-72863	22	57	control	control	NOUN
afs-72863	22	58	(	(	PUNCT
afs-72863	22	59	de	de	X
afs-72863	22	60	vos	vos	X
afs-72863	22	61	et	et	PROPN
afs-72863	22	62	al	al	PROPN
afs-72863	22	63	.	.	PROPN
afs-72863	22	64	1993	1993	NUM
afs-72863	22	65	,	,	PUNCT
afs-72863	22	66	gasson	gasson	NOUN
afs-72863	22	67	and	and	CCONJ
afs-72863	22	68	de	de	X
afs-72863	22	69	vos	vos	NOUN
afs-72863	22	70	1994	1994	NUM
afs-72863	22	71	,	,	PUNCT
afs-72863	22	72	venema	venema	NOUN
afs-72863	22	73	et	et	PROPN
afs-72863	22	74	al	al	PROPN
afs-72863	22	75	.	.	PROPN
afs-72863	22	76	1996	1996	NUM
afs-72863	22	77	)	)	PUNCT
afs-72863	22	78	.	.	PUNCT
afs-72863	23	1	we	we	PRON
afs-72863	23	2	are	be	AUX
afs-72863	23	3	gradually	gradually	ADV
afs-72863	23	4	accumulating	accumulate	VERB
afs-72863	23	5	a	a	DET
afs-72863	23	6	very	very	ADV
afs-72863	23	7	solid	solid	ADJ
afs-72863	23	8	and	and	CCONJ
afs-72863	23	9	promising	promising	ADJ
afs-72863	23	10	basis	basis	NOUN
afs-72863	23	11	for	for	ADP
afs-72863	23	12	the	the	DET
afs-72863	23	13	further	further	ADJ
afs-72863	23	14	development	development	NOUN
afs-72863	23	15	of	of	ADP
afs-72863	23	16	better	well	ADJ
afs-72863	23	17	and	and	CCONJ
afs-72863	23	18	safer	safe	ADJ
afs-72863	23	19	food	food	NOUN
afs-72863	23	20	products	product	NOUN
afs-72863	23	21	,	,	PUNCT
afs-72863	23	22	possibly	possibly	ADV
afs-72863	23	23	even	even	ADV
afs-72863	23	24	with	with	ADP
afs-72863	23	25	novel	novel	ADJ
afs-72863	23	26	characteristics	characteristic	NOUN
afs-72863	23	27	.	.	PUNCT
afs-72863	24	1	recently	recently	ADV
afs-72863	24	2	,	,	PUNCT
afs-72863	24	3	work	work	NOUN
afs-72863	24	4	has	have	AUX
afs-72863	24	5	begun	begin	VERB
afs-72863	24	6	on	on	ADP
afs-72863	24	7	elucidating	elucidate	VERB
afs-72863	24	8	the	the	DET
afs-72863	24	9	different	different	ADJ
afs-72863	24	10	health	health	NOUN
afs-72863	24	11	-	-	PUNCT
afs-72863	24	12	promoting	promote	VERB
afs-72863	24	13	effects	effect	NOUN
afs-72863	24	14	and	and	CCONJ
afs-72863	24	15	validating	validate	VERB
afs-72863	24	16	the	the	DET
afs-72863	24	17	claimed	claim	VERB
afs-72863	24	18	benefits	benefit	NOUN
afs-72863	24	19	of	of	ADP
afs-72863	24	20	probiotics	probiotic	NOUN
afs-72863	24	21	with	with	ADP
afs-72863	24	22	the	the	DET
afs-72863	24	23	aid	aid	NOUN
afs-72863	24	24	of	of	ADP
afs-72863	24	25	molecularbiology	molecularbiology	NOUN
afs-72863	24	26	(	(	PUNCT
afs-72863	24	27	klaenhammer	klaenhammer	NOUN
afs-72863	24	28	1995,tannock	1995,tannock	NUM
afs-72863	24	29	1995	1995	NUM
afs-72863	24	30	)	)	PUNCT
afs-72863	24	31	.	.	PUNCT
afs-72863	25	1	furthermore	furthermore	ADV
afs-72863	25	2	,	,	PUNCT
afs-72863	25	3	the	the	DET
afs-72863	25	4	development	development	NOUN
afs-72863	25	5	of	of	ADP
afs-72863	25	6	lab	lab	NOUN
afs-72863	25	7	as	as	ADP
afs-72863	25	8	oral	oral	ADJ
afs-72863	25	9	vaccine	vaccine	NOUN
afs-72863	25	10	carriers	carrier	NOUN
afs-72863	25	11	has	have	AUX
afs-72863	25	12	got	get	VERB
afs-72863	25	13	off	off	ADP
afs-72863	25	14	to	to	ADP
afs-72863	25	15	a	a	DET
afs-72863	25	16	promising	promising	ADJ
afs-72863	25	17	start	start	NOUN
afs-72863	25	18	(	(	PUNCT
afs-72863	25	19	wells	well	NOUN
afs-72863	25	20	et	et	PROPN
afs-72863	25	21	al	al	PROPN
afs-72863	25	22	.	.	PROPN
afs-72863	25	23	1996	1996	NUM
afs-72863	25	24	)	)	PUNCT
afs-72863	25	25	.	.	PUNCT
afs-72863	26	1	these	these	DET
afs-72863	26	2	new	new	ADJ
afs-72863	26	3	fields	field	NOUN
afs-72863	26	4	have	have	AUX
afs-72863	26	5	opened	open	VERB
afs-72863	26	6	fascinating	fascinating	ADJ
afs-72863	26	7	perspectives	perspective	NOUN
afs-72863	26	8	on	on	ADP
afs-72863	26	9	novel	novel	ADJ
afs-72863	26	10	utilisations	utilisation	NOUN
afs-72863	26	11	of	of	ADP
afs-72863	26	12	certain	certain	ADJ
afs-72863	26	13	lab	lab	NOUN
afs-72863	26	14	strains	strain	NOUN
afs-72863	26	15	.	.	PUNCT
afs-72863	27	1	eventually	eventually	ADV
afs-72863	27	2	such	such	ADJ
afs-72863	27	3	applications	application	NOUN
afs-72863	27	4	may	may	AUX
afs-72863	27	5	be	be	AUX
afs-72863	27	6	seen	see	VERB
afs-72863	27	7	as	as	ADP
afs-72863	27	8	evidence	evidence	NOUN
afs-72863	27	9	of	of	ADP
afs-72863	27	10	the	the	DET
afs-72863	27	11	major	major	ADJ
afs-72863	27	12	impact	impact	NOUN
afs-72863	27	13	modern	modern	ADJ
afs-72863	27	14	biotechnology	biotechnology	NOUN
afs-72863	27	15	can	can	AUX
afs-72863	27	16	have	have	VERB
afs-72863	27	17	on	on	ADP
afs-72863	27	18	the	the	DET
afs-72863	27	19	health	health	NOUN
afs-72863	27	20	and	and	CCONJ
afs-72863	27	21	nutrition	nutrition	NOUN
afs-72863	27	22	of	of	ADP
afs-72863	27	23	humans	human	NOUN
afs-72863	27	24	and	and	CCONJ
afs-72863	27	25	animals	animal	NOUN
afs-72863	27	26	.	.	PUNCT
afs-72863	28	1	this	this	DET
afs-72863	28	2	review	review	NOUN
afs-72863	28	3	summarises	summarise	NOUN
afs-72863	28	4	,	,	PUNCT
afs-72863	28	5	in	in	ADP
afs-72863	28	6	the	the	DET
afs-72863	28	7	context	context	NOUN
afs-72863	28	8	of	of	ADP
afs-72863	28	9	relevant	relevant	ADJ
afs-72863	28	10	research	research	NOUN
afs-72863	28	11	,	,	PUNCT
afs-72863	28	12	some	some	PRON
afs-72863	28	13	of	of	ADP
afs-72863	28	14	the	the	DET
afs-72863	28	15	contributions	contribution	NOUN
afs-72863	28	16	made	make	VERB
afs-72863	28	17	by	by	ADP
afs-72863	28	18	our	our	PRON
afs-72863	28	19	lab	lab	NOUN
afs-72863	28	20	research	research	NOUN
afs-72863	28	21	team	team	NOUN
afs-72863	28	22	to	to	ADP
afs-72863	28	23	efforts	effort	NOUN
afs-72863	28	24	to	to	PART
afs-72863	28	25	establish	establish	VERB
afs-72863	28	26	a	a	DET
afs-72863	28	27	basic	basic	ADJ
afs-72863	28	28	knowledge	knowledge	NOUN
afs-72863	28	29	base	base	NOUN
afs-72863	28	30	for	for	ADP
afs-72863	28	31	future	future	ADJ
afs-72863	28	32	food	food	NOUN
afs-72863	28	33	and	and	CCONJ
afs-72863	28	34	health	health	NOUN
afs-72863	28	35	-	-	PUNCT
afs-72863	28	36	promoting	promote	VERB
afs-72863	28	37	applications	application	NOUN
afs-72863	28	38	.	.	PUNCT
afs-72863	29	1	in	in	ADP
afs-72863	29	2	the	the	DET
afs-72863	29	3	first	first	ADJ
afs-72863	29	4	part	part	NOUN
afs-72863	29	5	of	of	ADP
afs-72863	29	6	the	the	DET
afs-72863	29	7	review	review	NOUN
afs-72863	29	8	i	i	PRON
afs-72863	29	9	shall	shall	AUX
afs-72863	29	10	examine	examine	VERB
afs-72863	29	11	the	the	DET
afs-72863	29	12	status	status	NOUN
afs-72863	29	13	of	of	ADP
afs-72863	29	14	our	our	PRON
afs-72863	29	15	work	work	NOUN
afs-72863	29	16	on	on	ADP
afs-72863	29	17	the	the	DET
afs-72863	29	18	molecular	molecular	ADJ
afs-72863	29	19	genetic	genetic	ADJ
afs-72863	29	20	characterisation	characterisation	NOUN
afs-72863	29	21	of	of	ADP
afs-72863	29	22	lactobacillarproteolytic	lactobacillarproteolytic	ADJ
afs-72863	29	23	systems	system	NOUN
afs-72863	29	24	.	.	PUNCT
afs-72863	30	1	the	the	DET
afs-72863	30	2	proteolytic	proteolytic	ADJ
afs-72863	30	3	systems	system	NOUN
afs-72863	30	4	of	of	ADP
afs-72863	30	5	lab	lab	NOUN
afs-72863	30	6	are	be	AUX
afs-72863	30	7	considered	consider	VERB
afs-72863	30	8	to	to	PART
afs-72863	30	9	have	have	VERB
afs-72863	30	10	an	an	DET
afs-72863	30	11	essential	essential	ADJ
afs-72863	30	12	impact	impact	NOUN
afs-72863	30	13	on	on	ADP
afs-72863	30	14	cheese	cheese	NOUN
afs-72863	30	15	ripening	ripening	NOUN
afs-72863	30	16	and	and	CCONJ
afs-72863	30	17	the	the	DET
afs-72863	30	18	formation	formation	NOUN
afs-72863	30	19	of	of	ADP
afs-72863	30	20	flavour	flavour	NOUN
afs-72863	30	21	and	and	CCONJ
afs-72863	30	22	texture	texture	NOUN
afs-72863	30	23	in	in	ADP
afs-72863	30	24	cheese	cheese	NOUN
afs-72863	30	25	.	.	PUNCT
afs-72863	31	1	the	the	DET
afs-72863	31	2	new	new	ADJ
afs-72863	31	3	information	information	NOUN
afs-72863	31	4	now	now	ADV
afs-72863	31	5	available	available	ADJ
afs-72863	31	6	on	on	ADP
afs-72863	31	7	cheese	cheese	NOUN
afs-72863	31	8	ripening	ripening	NOUN
afs-72863	31	9	and	and	CCONJ
afs-72863	31	10	the	the	DET
afs-72863	31	11	exact	exact	ADJ
afs-72863	31	12	role	role	NOUN
afs-72863	31	13	of	of	ADP
afs-72863	31	14	proteolytic	proteolytic	ADJ
afs-72863	31	15	and	and	CCONJ
afs-72863	31	16	peptidolytic	peptidolytic	ADJ
afs-72863	31	17	enzymes	enzyme	NOUN
afs-72863	31	18	in	in	ADP
afs-72863	31	19	the	the	DET
afs-72863	31	20	process	process	NOUN
afs-72863	31	21	will	will	AUX
afs-72863	31	22	aid	aid	VERB
afs-72863	31	23	the	the	DET
afs-72863	31	24	development	development	NOUN
afs-72863	31	25	of	of	ADP
afs-72863	31	26	low	low	ADJ
afs-72863	31	27	fat	fat	ADJ
afs-72863	31	28	cheeses	cheese	NOUN
afs-72863	31	29	with	with	ADP
afs-72863	31	30	a	a	DET
afs-72863	31	31	better	well	ADJ
afs-72863	31	32	health	health	NOUN
afs-72863	31	33	-	-	PUNCT
afs-72863	31	34	affecting	affect	VERB
afs-72863	31	35	status	status	NOUN
afs-72863	31	36	.	.	PUNCT
afs-72863	32	1	furthermore	furthermore	ADV
afs-72863	32	2	,	,	PUNCT
afs-72863	32	3	it	it	PRON
afs-72863	32	4	will	will	AUX
afs-72863	32	5	be	be	AUX
afs-72863	32	6	possible	possible	ADJ
afs-72863	32	7	to	to	PART
afs-72863	32	8	use	use	VERB
afs-72863	32	9	the	the	DET
afs-72863	32	10	characterised	characterise	VERB
afs-72863	32	11	enzymes	enzyme	NOUN
afs-72863	32	12	of	of	ADP
afs-72863	32	13	the	the	DET
afs-72863	32	14	proteolytic	proteolytic	ADJ
afs-72863	32	15	systems	system	NOUN
afs-72863	32	16	in	in	ADP
afs-72863	32	17	the	the	DET
afs-72863	32	18	targeted	target	VERB
afs-72863	32	19	production	production	NOUN
afs-72863	32	20	of	of	ADP
afs-72863	32	21	bioactive	bioactive	ADJ
afs-72863	32	22	peptides	peptide	NOUN
afs-72863	32	23	,	,	PUNCT
afs-72863	32	24	e.g.	e.g.	ADV
afs-72863	32	25	from	from	ADP
afs-72863	32	26	milk	milk	NOUN
afs-72863	32	27	proteins	protein	NOUN
afs-72863	32	28	.	.	PUNCT
afs-72863	33	1	in	in	ADP
afs-72863	33	2	the	the	DET
afs-72863	33	3	second	second	ADJ
afs-72863	33	4	part	part	NOUN
afs-72863	33	5	of	of	ADP
afs-72863	33	6	the	the	DET
afs-72863	33	7	review	review	NOUN
afs-72863	33	8	i	i	PRON
afs-72863	33	9	shall	shall	AUX
afs-72863	33	10	look	look	VERB
afs-72863	33	11	at	at	ADP
afs-72863	33	12	268	268	NUM
afs-72863	33	13	seminar	seminar	NOUN
afs-72863	33	14	in	in	ADP
afs-72863	33	15	honour	honour	NOUN
afs-72863	33	16	of	of	ADP
afs-72863	33	17	the	the	DET
afs-72863	33	18	100th	100th	ADJ
afs-72863	33	19	anniversary	anniversary	NOUN
afs-72863	33	20	ofmtt	ofmtt	NOUN
afs-72863	33	21	agricultural	agricultural	ADJ
afs-72863	33	22	and	and	CCONJ
afs-72863	33	23	food	food	NOUN
afs-72863	33	24	science	science	NOUN
afs-72863	33	25	in	in	ADP
afs-72863	33	26	finland	finland	PROPN
afs-72863	33	27	the	the	DET
afs-72863	33	28	molecular	molecular	ADJ
afs-72863	33	29	characterisation	characterisation	NOUN
afs-72863	33	30	of	of	ADP
afs-72863	33	31	the	the	DET
afs-72863	33	32	surface	surface	NOUN
afs-72863	33	33	layer	layer	NOUN
afs-72863	33	34	protein	protein	NOUN
afs-72863	33	35	(	(	PUNCT
afs-72863	33	36	s	s	NOUN
afs-72863	33	37	-	-	NOUN
afs-72863	33	38	protein	protein	NOUN
afs-72863	33	39	,	,	PUNCT
afs-72863	33	40	slpa	slpa	NOUN
afs-72863	33	41	)	)	PUNCT
afs-72863	33	42	and	and	CCONJ
afs-72863	33	43	gene	gene	NOUN
afs-72863	33	44	(	(	PUNCT
afs-72863	33	45	slpa	slpa	ADJ
afs-72863	33	46	)	)	PUNCT
afs-72863	33	47	oflactobacillus	oflactobacillus	NOUN
afs-72863	33	48	brevis	brevis	NOUN
afs-72863	33	49	and	and	CCONJ
afs-72863	33	50	the	the	DET
afs-72863	33	51	development	development	NOUN
afs-72863	33	52	of	of	ADP
afs-72863	33	53	a	a	DET
afs-72863	33	54	protein	protein	NOUN
afs-72863	33	55	production	production	NOUN
afs-72863	33	56	system	system	NOUN
afs-72863	33	57	based	base	VERB
afs-72863	33	58	on	on	ADP
afs-72863	33	59	the	the	DET
afs-72863	33	60	expression	expression	NOUN
afs-72863	33	61	and	and	CCONJ
afs-72863	33	62	secretion	secretion	NOUN
afs-72863	33	63	signals	signal	NOUN
afs-72863	33	64	ofslpa	ofslpa	ADV
afs-72863	33	65	.	.	PUNCT
afs-72863	34	1	the	the	DET
afs-72863	34	2	protein	protein	NOUN
afs-72863	34	3	production	production	NOUN
afs-72863	34	4	systems	system	NOUN
afs-72863	34	5	developed	develop	VERB
afs-72863	34	6	for	for	ADP
afs-72863	34	7	lab	lab	NOUN
afs-72863	34	8	are	be	AUX
afs-72863	34	9	still	still	ADV
afs-72863	34	10	rather	rather	ADV
afs-72863	34	11	unsophisticated	unsophisticated	ADJ
afs-72863	34	12	,	,	PUNCT
afs-72863	34	13	and	and	CCONJ
afs-72863	34	14	the	the	DET
afs-72863	34	15	factors	factor	NOUN
afs-72863	34	16	affecting	affect	VERB
afs-72863	34	17	protein	protein	NOUN
afs-72863	34	18	production	production	NOUN
afs-72863	34	19	,	,	PUNCT
afs-72863	34	20	secretion	secretion	NOUN
afs-72863	34	21	in	in	ADP
afs-72863	34	22	particular	particular	ADJ
afs-72863	34	23	,	,	PUNCT
afs-72863	34	24	poorly	poorly	ADV
afs-72863	34	25	characterised	characterise	VERB
afs-72863	34	26	compared	compare	VERB
afs-72863	34	27	with	with	ADP
afs-72863	34	28	those	those	PRON
afs-72863	34	29	established	establish	VERB
afs-72863	34	30	for	for	ADP
afs-72863	34	31	other	other	ADJ
afs-72863	34	32	proand	proand	NOUN
afs-72863	34	33	eukaryotic	eukaryotic	ADJ
afs-72863	34	34	organisms	organism	NOUN
afs-72863	34	35	.	.	PUNCT
afs-72863	35	1	furthermore	furthermore	ADV
afs-72863	35	2	,	,	PUNCT
afs-72863	35	3	the	the	DET
afs-72863	35	4	utility	utility	NOUN
afs-72863	35	5	of	of	ADP
afs-72863	35	6	the	the	DET
afs-72863	35	7	s	s	NOUN
afs-72863	35	8	-	-	NOUN
afs-72863	35	9	protein	protein	NOUN
afs-72863	35	10	itself	itself	PRON
afs-72863	35	11	as	as	ADP
afs-72863	35	12	a	a	DET
afs-72863	35	13	carrier	carrier	NOUN
afs-72863	35	14	of	of	ADP
afs-72863	35	15	vaccine	vaccine	NOUN
afs-72863	35	16	and	and	CCONJ
afs-72863	35	17	diagnostic	diagnostic	ADJ
afs-72863	35	18	antigens	antigen	NOUN
afs-72863	35	19	is	be	AUX
afs-72863	35	20	a	a	DET
afs-72863	35	21	key	key	ADJ
afs-72863	35	22	target	target	NOUN
afs-72863	35	23	of	of	ADP
afs-72863	35	24	current	current	ADJ
afs-72863	35	25	and	and	CCONJ
afs-72863	35	26	forthcoming	forthcoming	ADJ
afs-72863	35	27	research	research	NOUN
afs-72863	35	28	.	.	PUNCT
afs-72863	36	1	molecular	molecular	ADJ
afs-72863	36	2	genetic	genetic	ADJ
afs-72863	36	3	characterisation	characterisation	NOUN
afs-72863	36	4	of	of	ADP
afs-72863	36	5	components	component	NOUN
afs-72863	36	6	of	of	ADP
afs-72863	36	7	the	the	DET
afs-72863	36	8	proteolytic	proteolytic	ADJ
afs-72863	36	9	systems	system	NOUN
afs-72863	36	10	of	of	ADP
afs-72863	36	11	lactobacilli	lactobacilli	PROPN
afs-72863	36	12	general	general	ADJ
afs-72863	36	13	background	background	NOUN
afs-72863	36	14	many	many	ADJ
afs-72863	36	15	lab	lab	NOUN
afs-72863	36	16	isolated	isolate	VERB
afs-72863	36	17	from	from	ADP
afs-72863	36	18	milk	milk	NOUN
afs-72863	36	19	products	product	NOUN
afs-72863	36	20	are	be	AUX
afs-72863	36	21	multiple	multiple	ADJ
afs-72863	36	22	amino	amino	NOUN
afs-72863	36	23	acid	acid	NOUN
afs-72863	36	24	auxotrophs	auxotroph	NOUN
afs-72863	36	25	(	(	PUNCT
afs-72863	36	26	chopin	chopin	PROPN
afs-72863	36	27	1993	1993	NUM
afs-72863	36	28	)	)	PUNCT
afs-72863	36	29	.	.	PUNCT
afs-72863	37	1	in	in	ADP
afs-72863	37	2	milk	milk	NOUN
afs-72863	37	3	,	,	PUNCT
afs-72863	37	4	the	the	DET
afs-72863	37	5	abundances	abundance	NOUN
afs-72863	37	6	of	of	ADP
afs-72863	37	7	free	free	ADJ
afs-72863	37	8	amino	amino	NOUN
afs-72863	37	9	acids	acid	NOUN
afs-72863	37	10	and	and	CCONJ
afs-72863	37	11	shortpeptides	shortpeptide	NOUN
afs-72863	37	12	are	be	AUX
afs-72863	37	13	very	very	ADV
afs-72863	37	14	low	low	ADJ
afs-72863	37	15	.	.	PUNCT
afs-72863	38	1	to	to	PART
afs-72863	38	2	grow	grow	VERB
afs-72863	38	3	in	in	ADP
afs-72863	38	4	milk	milk	NOUN
afs-72863	38	5	lab	lab	NOUN
afs-72863	38	6	are	be	AUX
afs-72863	38	7	therefore	therefore	ADV
afs-72863	38	8	highly	highly	ADV
afs-72863	38	9	dependent	dependent	ADJ
afs-72863	38	10	on	on	ADP
afs-72863	38	11	their	their	PRON
afs-72863	38	12	proteolytic	proteolytic	ADJ
afs-72863	38	13	system	system	NOUN
afs-72863	38	14	.	.	PUNCT
afs-72863	39	1	the	the	DET
afs-72863	39	2	biochemical	biochemical	ADJ
afs-72863	39	3	and	and	CCONJ
afs-72863	39	4	genetic	genetic	ADJ
afs-72863	39	5	characteristics	characteristic	NOUN
afs-72863	39	6	of	of	ADP
afs-72863	39	7	the	the	DET
afs-72863	39	8	proteolytic	proteolytic	ADJ
afs-72863	39	9	system	system	NOUN
afs-72863	39	10	in	in	ADP
afs-72863	39	11	lactococci	lactococci	NOUN
afs-72863	39	12	have	have	AUX
afs-72863	39	13	been	be	AUX
afs-72863	39	14	extensively	extensively	ADV
afs-72863	39	15	studied	study	VERB
afs-72863	39	16	to	to	PART
afs-72863	39	17	ascertain	ascertain	VERB
afs-72863	39	18	the	the	DET
afs-72863	39	19	influence	influence	NOUN
afs-72863	39	20	of	of	ADP
afs-72863	39	21	the	the	DET
afs-72863	39	22	components	component	NOUN
afs-72863	39	23	of	of	ADP
afs-72863	39	24	the	the	DET
afs-72863	39	25	system	system	NOUN
afs-72863	39	26	on	on	ADP
afs-72863	39	27	the	the	DET
afs-72863	39	28	degradation	degradation	NOUN
afs-72863	39	29	of	of	ADP
afs-72863	39	30	milk	milk	NOUN
afs-72863	39	31	proteins	protein	NOUN
afs-72863	39	32	,	,	PUNCT
afs-72863	39	33	and	and	CCONJ
afs-72863	39	34	thus	thus	ADV
afs-72863	39	35	on	on	ADP
afs-72863	39	36	cheese	cheese	NOUN
afs-72863	39	37	ripening	ripening	NOUN
afs-72863	39	38	(	(	PUNCT
afs-72863	39	39	for	for	ADP
afs-72863	39	40	review	review	NOUN
afs-72863	39	41	,	,	PUNCT
afs-72863	39	42	see	see	VERB
afs-72863	39	43	kunji	kunji	X
afs-72863	39	44	et	et	PROPN
afs-72863	39	45	al	al	PROPN
afs-72863	39	46	.	.	PROPN
afs-72863	39	47	1996	1996	NUM
afs-72863	39	48	)	)	PUNCT
afs-72863	39	49	.	.	PUNCT
afs-72863	40	1	briefly	briefly	ADV
afs-72863	40	2	,	,	PUNCT
afs-72863	40	3	the	the	DET
afs-72863	40	4	proteolytic	proteolytic	ADJ
afs-72863	40	5	system	system	NOUN
afs-72863	40	6	in	in	ADP
afs-72863	40	7	lactococci	lactococci	NOUN
afs-72863	40	8	consists	consist	VERB
afs-72863	40	9	of	of	ADP
afs-72863	40	10	:	:	PUNCT
afs-72863	40	11	i	i	NOUN
afs-72863	40	12	)	)	PUNCT
afs-72863	40	13	the	the	DET
afs-72863	40	14	cell	cell	NOUN
afs-72863	40	15	wall	wall	NOUN
afs-72863	40	16	-	-	PUNCT
afs-72863	40	17	associatedproteinase	associatedproteinase	NOUN
afs-72863	40	18	(	(	PUNCT
afs-72863	40	19	prtp	prtp	ADJ
afs-72863	40	20	)	)	PUNCT
afs-72863	40	21	,	,	PUNCT
afs-72863	40	22	which	which	PRON
afs-72863	40	23	degrades	degrade	VERB
afs-72863	40	24	casein	casein	NOUN
afs-72863	40	25	into	into	ADP
afs-72863	40	26	oligopeptides	oligopeptide	NOUN
afs-72863	40	27	;	;	PUNCT
afs-72863	40	28	ii	ii	X
afs-72863	40	29	)	)	PUNCT
afs-72863	40	30	amino	amino	NOUN
afs-72863	40	31	acid	acid	NOUN
afs-72863	40	32	and	and	CCONJ
afs-72863	40	33	peptide	peptide	NOUN
afs-72863	40	34	transport	transport	NOUN
afs-72863	40	35	systems	system	NOUN
afs-72863	40	36	,	,	PUNCT
afs-72863	40	37	which	which	PRON
afs-72863	40	38	supply	supply	VERB
afs-72863	40	39	the	the	DET
afs-72863	40	40	degraded	degraded	ADJ
afs-72863	40	41	organic	organic	ADJ
afs-72863	40	42	nitrogen	nitrogen	NOUN
afs-72863	40	43	source	source	NOUN
afs-72863	40	44	to	to	ADP
afs-72863	40	45	the	the	DET
afs-72863	40	46	cell	cell	NOUN
afs-72863	40	47	by	by	ADP
afs-72863	40	48	translocating	translocate	VERB
afs-72863	40	49	the	the	DET
afs-72863	40	50	breakdown	breakdown	ADJ
afs-72863	40	51	products	product	NOUN
afs-72863	40	52	of	of	ADP
afs-72863	40	53	casein	casein	NOUN
afs-72863	40	54	across	across	ADP
afs-72863	40	55	the	the	DET
afs-72863	40	56	cytoplasmic	cytoplasmic	ADJ
afs-72863	40	57	membrane	membrane	NOUN
afs-72863	40	58	;	;	PUNCT
afs-72863	40	59	and	and	CCONJ
afs-72863	40	60	iii	iii	X
afs-72863	40	61	)	)	PUNCT
afs-72863	40	62	many	many	ADJ
afs-72863	40	63	different	different	ADJ
afs-72863	40	64	intracellular	intracellular	NOUN
afs-72863	40	65	exoand	exoand	NOUN
afs-72863	40	66	endopeptidases	endopeptidase	NOUN
afs-72863	40	67	,	,	PUNCT
afs-72863	40	68	which	which	PRON
afs-72863	40	69	further	far	ADV
afs-72863	40	70	cleave	cleave	VERB
afs-72863	40	71	oligopeptides	oligopeptide	NOUN
afs-72863	40	72	into	into	ADP
afs-72863	40	73	shorter	short	ADJ
afs-72863	40	74	peptides	peptide	NOUN
afs-72863	40	75	and	and	CCONJ
afs-72863	40	76	amino	amino	ADJ
afs-72863	40	77	acids	acid	NOUN
afs-72863	40	78	(	(	PUNCT
afs-72863	40	79	kunji	kunji	X
afs-72863	40	80	et	et	PROPN
afs-72863	40	81	al	al	PROPN
afs-72863	40	82	.	.	PROPN
afs-72863	40	83	1996	1996	NUM
afs-72863	40	84	,	,	PUNCT
afs-72863	40	85	fig	fig	NOUN
afs-72863	40	86	.	.	NOUN
afs-72863	41	1	1	1	NUM
afs-72863	41	2	)	)	PUNCT
afs-72863	41	3	.	.	PUNCT
afs-72863	42	1	molecular	molecular	ADJ
afs-72863	42	2	characterisation	characterisation	NOUN
afs-72863	42	3	of	of	ADP
afs-72863	42	4	lactobacillar	lactobacillar	ADJ
afs-72863	42	5	proteolytic	proteolytic	ADJ
afs-72863	42	6	systems	system	NOUN
afs-72863	42	7	,	,	PUNCT
afs-72863	42	8	mainly	mainly	ADV
afs-72863	42	9	oflactobacillus	oflactobacillus	ADP
afs-72863	42	10	delbrueckii	delbrueckii	ADJ
afs-72863	42	11	ssp	ssp	PROPN
afs-72863	42	12	.	.	PUNCT
afs-72863	43	1	lactis	lactis	PROPN
afs-72863	43	2	,	,	PUNCT
afs-72863	43	3	lactobacillus	lactobacillus	X
afs-72863	43	4	helveticus	helveticus	NOUN
afs-72863	43	5	and	and	CCONJ
afs-72863	43	6	lactobacillus	lactobacillus	NOUN
afs-72863	43	7	paracasei	paracasei	NOUN
afs-72863	43	8	,	,	PUNCT
afs-72863	43	9	even	even	ADV
afs-72863	43	10	though	though	SCONJ
afs-72863	43	11	it	it	PRON
afs-72863	43	12	got	get	VERB
afs-72863	43	13	under	under	ADP
afs-72863	43	14	way	way	NOUN
afs-72863	43	15	several	several	ADJ
afs-72863	43	16	years	year	NOUN
afs-72863	43	17	after	after	ADP
afs-72863	43	18	that	that	PRON
afs-72863	43	19	of	of	ADP
afs-72863	43	20	lactococci	lactococci	NOUN
afs-72863	43	21	,	,	PUNCT
afs-72863	43	22	has	have	AUX
afs-72863	43	23	made	make	VERB
afs-72863	43	24	rapid	rapid	ADJ
afs-72863	43	25	progress	progress	NOUN
afs-72863	43	26	.	.	PUNCT
afs-72863	44	1	we	we	PRON
afs-72863	44	2	now	now	ADV
afs-72863	44	3	have	have	VERB
afs-72863	44	4	large	large	ADJ
afs-72863	44	5	knowledge	knowledge	NOUN
afs-72863	44	6	base	base	NOUN
afs-72863	44	7	on	on	ADP
afs-72863	44	8	these	these	DET
afs-72863	44	9	bacteria	bacteria	NOUN
afs-72863	44	10	too	too	ADV
afs-72863	44	11	,	,	PUNCT
afs-72863	44	12	and	and	CCONJ
afs-72863	44	13	it	it	PRON
afs-72863	44	14	has	have	AUX
afs-72863	44	15	become	become	VERB
afs-72863	44	16	clear	clear	ADJ
afs-72863	44	17	that	that	SCONJ
afs-72863	44	18	a	a	DET
afs-72863	44	19	close	close	ADJ
afs-72863	44	20	overall	overall	ADJ
afs-72863	44	21	similarity	similarity	NOUN
afs-72863	44	22	exits	exit	VERB
afs-72863	44	23	between	between	ADP
afs-72863	44	24	the	the	DET
afs-72863	44	25	lactobacillarproteolytic	lactobacillarproteolytic	ADJ
afs-72863	44	26	systems	system	NOUN
afs-72863	44	27	and	and	CCONJ
afs-72863	44	28	the	the	DET
afs-72863	44	29	lactococci	lactococci	NOUN
afs-72863	44	30	(	(	PUNCT
afs-72863	44	31	kunji	kunji	X
afs-72863	44	32	et	et	PROPN
afs-72863	44	33	al	al	PROPN
afs-72863	44	34	.	.	PROPN
afs-72863	44	35	1996	1996	NUM
afs-72863	44	36	)	)	PUNCT
afs-72863	44	37	.	.	PUNCT
afs-72863	45	1	due	due	ADP
afs-72863	45	2	to	to	ADP
afs-72863	45	3	their	their	PRON
afs-72863	45	4	high	high	ADJ
afs-72863	45	5	peptidolytic	peptidolytic	ADJ
afs-72863	45	6	activity	activity	NOUN
afs-72863	45	7	,	,	PUNCT
afs-72863	45	8	lactobacilli	lactobacilli	PROPN
afs-72863	45	9	,	,	PUNCT
afs-72863	45	10	l.	l.	PROPN
afs-72863	45	11	helveticus	helveticus	PROPN
afs-72863	45	12	in	in	ADP
afs-72863	45	13	particular	particular	ADJ
afs-72863	45	14	,	,	PUNCT
afs-72863	45	15	have	have	AUX
afs-72863	45	16	been	be	AUX
afs-72863	45	17	used	use	VERB
afs-72863	45	18	in	in	ADP
afs-72863	45	19	various	various	ADJ
afs-72863	45	20	forms	form	NOUN
afs-72863	45	21	to	to	PART
afs-72863	45	22	reduce	reduce	VERB
afs-72863	45	23	bitterness	bitterness	NOUN
afs-72863	45	24	,	,	PUNCT
afs-72863	45	25	improve	improve	VERB
afs-72863	45	26	flavour	flavour	ADJ
afs-72863	45	27	development	development	NOUN
afs-72863	45	28	and	and	CCONJ
afs-72863	45	29	accelerate	accelerate	VERB
afs-72863	45	30	the	the	DET
afs-72863	45	31	ripening	ripening	NOUN
afs-72863	45	32	of	of	ADP
afs-72863	45	33	various	various	ADJ
afs-72863	45	34	types	type	NOUN
afs-72863	45	35	of	of	ADP
afs-72863	45	36	cheese	cheese	NOUN
afs-72863	45	37	in	in	ADP
afs-72863	45	38	processes	process	NOUN
afs-72863	45	39	conventionally	conventionally	ADV
afs-72863	45	40	based	base	VERB
afs-72863	45	41	on	on	ADP
afs-72863	45	42	the	the	DET
afs-72863	45	43	use	use	NOUN
afs-72863	45	44	of	of	ADP
afs-72863	45	45	other	other	ADJ
afs-72863	45	46	starter	starter	NOUN
afs-72863	45	47	strains	strain	NOUN
afs-72863	45	48	(	(	PUNCT
afs-72863	45	49	ardö	ardö	NOUN
afs-72863	45	50	and	and	CCONJ
afs-72863	45	51	larsson	larsson	PROPN
afs-72863	45	52	1989	1989	NUM
afs-72863	45	53	,	,	PUNCT
afs-72863	45	54	bartels	bartel	VERB
afs-72863	45	55	et	et	PROPN
afs-72863	45	56	al	al	PROPN
afs-72863	45	57	.	.	PROPN
afs-72863	45	58	1987a	1987a	NUM
afs-72863	45	59	,	,	PUNCT
afs-72863	45	60	b	b	X
afs-72863	45	61	,	,	PUNCT
afs-72863	45	62	el	el	PROPN
afs-72863	45	63	soda	soda	PROPN
afs-72863	45	64	1993	1993	NUM
afs-72863	45	65	)	)	PUNCT
afs-72863	45	66	.	.	PUNCT
afs-72863	46	1	thus	thus	ADV
afs-72863	46	2	,	,	PUNCT
afs-72863	46	3	genetic	genetic	ADJ
afs-72863	46	4	characterisation	characterisation	NOUN
afs-72863	46	5	of	of	ADP
afs-72863	46	6	the	the	DET
afs-72863	46	7	components	component	NOUN
afs-72863	46	8	of	of	ADP
afs-72863	46	9	the	the	DET
afs-72863	46	10	lactobacillar	lactobacillar	ADJ
afs-72863	46	11	proteolytic	proteolytic	ADJ
afs-72863	46	12	systems	system	NOUN
afs-72863	46	13	will	will	AUX
afs-72863	46	14	enable	enable	VERB
afs-72863	46	15	us	we	PRON
afs-72863	46	16	to	to	PART
afs-72863	46	17	develop	develop	VERB
afs-72863	46	18	more	more	ADV
afs-72863	46	19	precise	precise	ADJ
afs-72863	46	20	modifications	modification	NOUN
afs-72863	46	21	of	of	ADP
afs-72863	46	22	starter	starter	ADJ
afs-72863	46	23	bacteria	bacteria	NOUN
afs-72863	46	24	for	for	ADP
afs-72863	46	25	improvements	improvement	NOUN
afs-72863	46	26	to	to	ADP
afs-72863	46	27	lowfat	lowfat	NOUN
afs-72863	46	28	cheeses	cheese	NOUN
afs-72863	46	29	and	and	CCONJ
afs-72863	46	30	many	many	ADJ
afs-72863	46	31	other	other	ADJ
afs-72863	46	32	processes	process	NOUN
afs-72863	46	33	in	in	ADP
afs-72863	46	34	the	the	DET
afs-72863	46	35	food	food	NOUN
afs-72863	46	36	industry	industry	NOUN
afs-72863	46	37	.	.	PUNCT
afs-72863	47	1	to	to	ADP
afs-72863	47	2	date	date	NOUN
afs-72863	47	3	,	,	PUNCT
afs-72863	47	4	the	the	DET
afs-72863	47	5	cell	cell	NOUN
afs-72863	47	6	wall	wall	NOUN
afs-72863	47	7	-	-	PUNCT
afs-72863	47	8	bound	bind	VERB
afs-72863	47	9	proteinase	proteinase	NOUN
afs-72863	47	10	has	have	AUX
afs-72863	47	11	been	be	AUX
afs-72863	47	12	characterised	characterise	VERB
afs-72863	47	13	from	from	ADP
afs-72863	47	14	several	several	ADJ
afs-72863	47	15	lactococcus	lactococcus	NOUN
afs-72863	47	16	lactis	lactis	NOUN
afs-72863	47	17	subsp	subsp	NOUN
afs-72863	47	18	.	.	PUNCT
afs-72863	48	1	cremoris	cremoris	PROPN
afs-72863	48	2	strains	strain	VERB
afs-72863	48	3	,	,	PUNCT
afs-72863	48	4	two	two	NUM
afs-72863	48	5	lactobacillus	lactobacillus	NOUN
afs-72863	48	6	casei	casei	VERB
afs-72863	48	7	,	,	PUNCT
afs-72863	48	8	one	one	NUM
afs-72863	48	9	lactobacillus	lactobacillus	NOUN
afs-72863	48	10	delbrueckii	delbrueckii	VERB
afs-72863	48	11	subsp	subsp	NOUN
afs-72863	48	12	bulgaricus	bulgaricus	NOUN
afs-72863	48	13	and	and	CCONJ
afs-72863	48	14	three	three	NUM
afs-72863	48	15	l.	l.	PROPN
afs-72863	48	16	helveticus	helveticus	PROPN
afs-72863	48	17	strains	strain	VERB
afs-72863	48	18	,	,	PUNCT
afs-72863	48	19	and	and	CCONJ
afs-72863	48	20	the	the	DET
afs-72863	48	21	substrate	substrate	NOUN
afs-72863	48	22	specificities	specificity	NOUN
afs-72863	48	23	of	of	ADP
afs-72863	48	24	lactococcal	lactococcal	ADJ
afs-72863	48	25	prts	prt	NOUN
afs-72863	48	26	have	have	AUX
afs-72863	48	27	been	be	AUX
afs-72863	48	28	described	describe	VERB
afs-72863	48	29	in	in	ADP
afs-72863	48	30	detail	detail	NOUN
afs-72863	48	31	(	(	PUNCT
afs-72863	48	32	kunji	kunji	X
afs-72863	48	33	et	et	PROPN
afs-72863	48	34	al	al	PROPN
afs-72863	48	35	.	.	PUNCT
afs-72863	49	1	1996).amino	1996).amino	NUM
afs-72863	49	2	acid	acid	ADJ
afs-72863	49	3	and	and	CCONJ
afs-72863	49	4	peptide	peptide	NOUN
afs-72863	49	5	transport	transport	NOUN
afs-72863	49	6	systems	system	NOUN
afs-72863	49	7	have	have	AUX
afs-72863	49	8	been	be	AUX
afs-72863	49	9	studied	study	VERB
afs-72863	49	10	mainly	mainly	ADV
afs-72863	49	11	in	in	ADP
afs-72863	49	12	lactococci	lactococci	NOUN
afs-72863	49	13	,	,	PUNCT
afs-72863	49	14	for	for	ADP
afs-72863	49	15	which	which	PRON
afs-72863	49	16	10	10	NUM
afs-72863	49	17	amino	amino	NOUN
afs-72863	49	18	acid	acid	NOUN
afs-72863	49	19	transport	transport	NOUN
afs-72863	49	20	systems	system	NOUN
afs-72863	49	21	have	have	AUX
afs-72863	49	22	been	be	AUX
afs-72863	49	23	found	find	VERB
afs-72863	49	24	but	but	CCONJ
afs-72863	49	25	not	not	PART
afs-72863	49	26	yet	yet	ADV
afs-72863	49	27	cloned	clone	VERB
afs-72863	49	28	.	.	PUNCT
afs-72863	50	1	the	the	DET
afs-72863	50	2	lactococcal	lactococcal	PROPN
afs-72863	50	3	di	di	NOUN
afs-72863	50	4	/	/	SYM
afs-72863	50	5	tripeptide	tripeptide	ADJ
afs-72863	50	6	transporters	transporter	NOUN
afs-72863	50	7	and	and	CCONJ
afs-72863	50	8	the	the	DET
afs-72863	50	9	oligopeptide	oligopeptide	NOUN
afs-72863	50	10	transport	transport	NOUN
afs-72863	50	11	systems	system	NOUN
afs-72863	50	12	have	have	AUX
afs-72863	50	13	been	be	AUX
afs-72863	50	14	extensively	extensively	ADV
afs-72863	50	15	analysed	analyse	VERB
afs-72863	50	16	and	and	CCONJ
afs-72863	50	17	even	even	ADV
afs-72863	50	18	genetically	genetically	ADV
afs-72863	50	19	modified	modify	VERB
afs-72863	50	20	(	(	PUNCT
afs-72863	50	21	kunji	kunji	X
afs-72863	50	22	et	et	PROPN
afs-72863	50	23	al	al	PROPN
afs-72863	50	24	.	.	PROPN
afs-72863	50	25	1996	1996	NUM
afs-72863	50	26	)	)	PUNCT
afs-72863	50	27	.	.	PUNCT
afs-72863	51	1	the	the	DET
afs-72863	51	2	most	most	ADV
afs-72863	51	3	extensive	extensive	ADJ
afs-72863	51	4	molecular	molecular	ADJ
afs-72863	51	5	characterisation	characterisation	NOUN
afs-72863	51	6	work	work	NOUN
afs-72863	51	7	has	have	AUX
afs-72863	51	8	,	,	PUNCT
afs-72863	51	9	however	however	ADV
afs-72863	51	10	,	,	PUNCT
afs-72863	51	11	been	be	AUX
afs-72863	51	12	done	do	VERB
afs-72863	51	13	on	on	ADP
afs-72863	51	14	peptidases	peptidase	NOUN
afs-72863	51	15	.	.	PUNCT
afs-72863	52	1	thus	thus	ADV
afs-72863	52	2	far	far	ADV
afs-72863	52	3	,	,	PUNCT
afs-72863	52	4	dozens	dozen	NOUN
afs-72863	52	5	of	of	ADP
afs-72863	52	6	peptidases	peptidase	NOUN
afs-72863	52	7	have	have	AUX
afs-72863	52	8	been	be	AUX
afs-72863	52	9	analysed	analyse	VERB
afs-72863	52	10	,	,	PUNCT
afs-72863	52	11	from	from	ADP
afs-72863	52	12	lactococcus	lactococcus	PROPN
afs-72863	52	13	lactis	lactis	PROPN
afs-72863	52	14	subsp	subsp	PROPN
afs-72863	52	15	.	.	PUNCT
afs-72863	53	1	cremoris	cremoris	PROPN
afs-72863	53	2	strains	strain	VERB
afs-72863	53	3	,	,	PUNCT
afs-72863	53	4	l.	l.	PROPN
afs-72863	53	5	delbrueckii	delbrueckii	PROPN
afs-72863	53	6	subsp	subsp	PROPN
afs-72863	53	7	.	.	PUNCT
afs-72863	54	1	lactis	lactis	PROPN
afs-72863	54	2	,	,	PUNCT
afs-72863	54	3	l.	l.	PROPN
afs-72863	54	4	helveticus	helveticus	PROPN
afs-72863	54	5	and	and	CCONJ
afs-72863	54	6	other	other	ADJ
afs-72863	54	7	lab	lab	NOUN
afs-72863	54	8	,	,	PUNCT
afs-72863	54	9	including	include	VERB
afs-72863	54	10	at	at	ADP
afs-72863	54	11	least	least	ADV
afs-72863	54	12	12	12	NUM
afs-72863	54	13	peptidases	peptidase	NOUN
afs-72863	54	14	with	with	ADP
afs-72863	54	15	distinct	distinct	ADJ
afs-72863	54	16	substrate	substrate	NOUN
afs-72863	54	17	specificities	specificity	NOUN
afs-72863	54	18	(	(	PUNCT
afs-72863	54	19	see	see	VERB
afs-72863	54	20	kunji	kunji	X
afs-72863	54	21	et	et	PROPN
afs-72863	54	22	al	al	PROPN
afs-72863	54	23	.	.	PROPN
afs-72863	54	24	1996	1996	NUM
afs-72863	54	25	)	)	PUNCT
afs-72863	54	26	.	.	PUNCT
afs-72863	55	1	269	269	NUM
afs-72863	55	2	vol	vol	NOUN
afs-72863	55	3	.	.	PUNCT
afs-72863	56	1	7(1998	7(1998	NUM
afs-72863	56	2	):	):	PUNCT
afs-72863	56	3	267	267	NUM
afs-72863	56	4	-	-	SYM
afs-72863	56	5	282	282	NUM
afs-72863	56	6	.	.	PUNCT
afs-72863	57	1	agricultural	agricultural	ADJ
afs-72863	57	2	and	and	CCONJ
afs-72863	57	3	food	food	NOUN
afs-72863	57	4	science	science	NOUN
afs-72863	57	5	in	in	ADP
afs-72863	57	6	finland	finland	PROPN
afs-72863	57	7	the	the	DET
afs-72863	57	8	characterisation	characterisation	NOUN
afs-72863	57	9	of	of	ADP
afs-72863	57	10	lactobacillar	lactobacillar	ADJ
afs-72863	57	11	proteolytic	proteolytic	ADJ
afs-72863	57	12	systems	system	NOUN
afs-72863	57	13	our	our	PRON
afs-72863	57	14	laboratory	laboratory	NOUN
afs-72863	57	15	has	have	AUX
afs-72863	57	16	sought	seek	VERB
afs-72863	57	17	to	to	PART
afs-72863	57	18	characterise	characterise	VERB
afs-72863	57	19	thekey	thekey	NOUN
afs-72863	57	20	components	component	NOUN
afs-72863	57	21	ofand	ofand	NOUN
afs-72863	57	22	events	event	NOUN
afs-72863	57	23	in	in	ADP
afs-72863	57	24	the	the	DET
afs-72863	57	25	proteolytic	proteolytic	ADJ
afs-72863	57	26	system	system	NOUN
afs-72863	57	27	of	of	ADP
afs-72863	57	28	thermophilic	thermophilic	ADJ
afs-72863	57	29	industrial	industrial	ADJ
afs-72863	57	30	lactobacilli	lactobacilli	NOUN
afs-72863	57	31	,	,	PUNCT
afs-72863	57	32	with	with	ADP
afs-72863	57	33	special	special	ADJ
afs-72863	57	34	emphasis	emphasis	NOUN
afs-72863	57	35	on	on	ADP
afs-72863	57	36	l.	l.	PROPN
afs-72863	57	37	helveticus	helveticus	PROPN
afs-72863	57	38	and	and	CCONJ
afs-72863	57	39	l.	l.	PROPN
afs-72863	57	40	delbrueckii	delbrueckii	PROPN
afs-72863	57	41	subsp	subsp	PROPN
afs-72863	57	42	.	.	PUNCT
afs-72863	58	1	bulgaricus	bulgaricus	VERB
afs-72863	58	2	.	.	PUNCT
afs-72863	59	1	the	the	DET
afs-72863	59	2	l.	l.	PROPN
afs-72863	59	3	helveticus	helveticus	PROPN
afs-72863	59	4	we	we	PRON
afs-72863	59	5	have	have	AUX
afs-72863	59	6	used	use	VERB
afs-72863	59	7	in	in	ADP
afs-72863	59	8	our	our	PRON
afs-72863	59	9	studies	study	NOUN
afs-72863	59	10	is	be	AUX
afs-72863	59	11	an	an	DET
afs-72863	59	12	industrially	industrially	ADV
afs-72863	59	13	utilised	utilise	VERB
afs-72863	59	14	strain	strain	NOUN
afs-72863	59	15	,	,	PUNCT
afs-72863	59	16	53/7	53/7	NUM
afs-72863	59	17	,	,	PUNCT
afs-72863	59	18	with	with	ADP
afs-72863	59	19	highly	highly	ADV
afs-72863	59	20	favourable	favourable	ADJ
afs-72863	59	21	peptidolytic	peptidolytic	ADJ
afs-72863	59	22	characteristics	characteristic	NOUN
afs-72863	59	23	.	.	PUNCT
afs-72863	60	1	during	during	ADP
afs-72863	60	2	the	the	DET
afs-72863	60	3	past	past	ADJ
afs-72863	60	4	five	five	NUM
afs-72863	60	5	years	year	NOUN
afs-72863	60	6	we	we	PRON
afs-72863	60	7	have	have	AUX
afs-72863	60	8	completed	complete	VERB
afs-72863	60	9	the	the	DET
afs-72863	60	10	molecular	molecular	ADJ
afs-72863	60	11	genetic	genetic	ADJ
afs-72863	60	12	characterisation	characterisation	NOUN
afs-72863	60	13	of	of	ADP
afs-72863	60	14	six	six	NUM
afs-72863	60	15	l.	l.	PROPN
afs-72863	60	16	helveticus	helveticus	PROPN
afs-72863	60	17	and	and	CCONJ
afs-72863	60	18	two	two	NUM
afs-72863	60	19	l.	l.	PROPN
afs-72863	60	20	delbrueckii	delbrueckii	PROPN
afs-72863	60	21	subsp	subsp	PROPN
afs-72863	60	22	.	.	PUNCT
afs-72863	61	1	bulgaricus	bulgaricus	NOUN
afs-72863	61	2	peptidases	peptidase	NOUN
afs-72863	61	3	.	.	PUNCT
afs-72863	62	1	we	we	PRON
afs-72863	62	2	are	be	AUX
afs-72863	62	3	currently	currently	ADV
afs-72863	62	4	engaged	engage	VERB
afs-72863	62	5	in	in	ADP
afs-72863	62	6	cloning	cloning	NOUN
afs-72863	62	7	and	and	CCONJ
afs-72863	62	8	sequencing	sequence	VERB
afs-72863	62	9	a	a	DET
afs-72863	62	10	novel	novel	ADJ
afs-72863	62	11	type	type	NOUN
afs-72863	62	12	of	of	ADP
afs-72863	62	13	prtp	prtp	NOUN
afs-72863	62	14	and	and	CCONJ
afs-72863	62	15	a	a	DET
afs-72863	62	16	tripeptidase	tripeptidase	NOUN
afs-72863	62	17	from	from	ADP
afs-72863	62	18	l.	l.	PROPN
afs-72863	62	19	helveticus	helveticus	PROPN
afs-72863	62	20	(	(	PUNCT
afs-72863	62	21	data	datum	NOUN
afs-72863	62	22	not	not	PART
afs-72863	62	23	shown	show	VERB
afs-72863	62	24	)	)	PUNCT
afs-72863	62	25	.	.	PUNCT
afs-72863	63	1	characterisation	characterisation	NOUN
afs-72863	63	2	of	of	ADP
afs-72863	63	3	these	these	DET
afs-72863	63	4	components	component	NOUN
afs-72863	63	5	has	have	AUX
afs-72863	63	6	allowed	allow	VERB
afs-72863	63	7	us	we	PRON
afs-72863	63	8	to	to	PART
afs-72863	63	9	:	:	PUNCT
afs-72863	63	10	i	i	NOUN
afs-72863	63	11	)	)	PUNCT
afs-72863	63	12	initiate	initiate	VERB
afs-72863	63	13	construction	construction	NOUN
afs-72863	63	14	of	of	ADP
afs-72863	63	15	modified	modify	VERB
afs-72863	63	16	lactococcal	lactococcal	ADJ
afs-72863	63	17	starter	starter	NOUN
afs-72863	63	18	strains	strain	NOUN
afs-72863	63	19	(	(	PUNCT
afs-72863	63	20	an	an	DET
afs-72863	63	21	eu	eu	ADJ
afs-72863	63	22	-	-	ADJ
afs-72863	63	23	biotech	biotech	ADJ
afs-72863	63	24	ii	ii	NOUN
afs-72863	63	25	starlab	starlab	NOUN
afs-72863	63	26	project	project	NOUN
afs-72863	63	27	)	)	PUNCT
afs-72863	63	28	;	;	PUNCT
afs-72863	63	29	ii	ii	X
afs-72863	63	30	)	)	PUNCT
afs-72863	63	31	analyse	analyse	NOUN
afs-72863	63	32	theregulation	theregulation	NOUN
afs-72863	63	33	and	and	CCONJ
afs-72863	63	34	interactions	interaction	NOUN
afs-72863	63	35	of	of	ADP
afs-72863	63	36	the	the	DET
afs-72863	63	37	peptidase	peptidase	NOUN
afs-72863	63	38	genes	gene	NOUN
afs-72863	63	39	in	in	ADP
afs-72863	63	40	l.	l.	PROPN
afs-72863	63	41	helveticus	helveticus	PROPN
afs-72863	63	42	(	(	PUNCT
afs-72863	63	43	in	in	ADP
afs-72863	63	44	collaboration	collaboration	NOUN
afs-72863	63	45	with	with	ADP
afs-72863	63	46	the	the	DET
afs-72863	63	47	department	department	NOUN
afs-72863	63	48	of	of	ADP
afs-72863	63	49	food	food	NOUN
afs-72863	63	50	science	science	NOUN
afs-72863	63	51	,	,	PUNCT
afs-72863	63	52	university	university	PROPN
afs-72863	63	53	of	of	ADP
afs-72863	63	54	wisconsin	wisconsin	PROPN
afs-72863	63	55	-	-	PUNCT
afs-72863	63	56	madison	madison	PROPN
afs-72863	63	57	)	)	PUNCT
afs-72863	63	58	,	,	PUNCT
afs-72863	63	59	iii	iii	X
afs-72863	63	60	)	)	PUNCT
afs-72863	63	61	test	test	NOUN
afs-72863	63	62	modifiedl	modifiedl	VERB
afs-72863	63	63	.	.	PUNCT
afs-72863	64	1	helveticus	helveticus	NOUN
afs-72863	64	2	strains	strain	VERB
afs-72863	64	3	in	in	ADP
afs-72863	64	4	a	a	DET
afs-72863	64	5	cheese	cheese	NOUN
afs-72863	64	6	process	process	NOUN
afs-72863	64	7	with	with	ADP
afs-72863	64	8	an	an	DET
afs-72863	64	9	industrial	industrial	ADJ
afs-72863	64	10	partner	partner	NOUN
afs-72863	64	11	;	;	PUNCT
afs-72863	64	12	and	and	CCONJ
afs-72863	64	13	iv	iv	X
afs-72863	64	14	)	)	PUNCT
afs-72863	64	15	test	test	NOUN
afs-72863	64	16	the	the	DET
afs-72863	64	17	overproduction	overproduction	NOUN
afs-72863	64	18	of	of	ADP
afs-72863	64	19	individual	individual	ADJ
afs-72863	64	20	peptidases	peptidase	NOUN
afs-72863	64	21	.	.	PUNCT
afs-72863	65	1	cloning	clone	VERB
afs-72863	65	2	the	the	DET
afs-72863	65	3	oligopeptide	oligopeptide	NOUN
afs-72863	65	4	transport	transport	NOUN
afs-72863	65	5	system	system	NOUN
afs-72863	65	6	from	from	ADP
afs-72863	65	7	l.	l.	PROPN
afs-72863	65	8	delbrueckii	delbrueckii	PROPN
afs-72863	65	9	subsp	subsp	PROPN
afs-72863	65	10	.	.	PUNCT
afs-72863	66	1	bulgaricus	bulgaricus	NOUN
afs-72863	66	2	will	will	AUX
afs-72863	66	3	allow	allow	VERB
afs-72863	66	4	us	we	PRON
afs-72863	66	5	to	to	PART
afs-72863	66	6	compare	compare	VERB
afs-72863	66	7	the	the	DET
afs-72863	66	8	specificity	specificity	NOUN
afs-72863	66	9	and	and	CCONJ
afs-72863	66	10	capacity	capacity	NOUN
afs-72863	66	11	of	of	ADP
afs-72863	66	12	the	the	DET
afs-72863	66	13	transport	transport	NOUN
afs-72863	66	14	systems	system	NOUN
afs-72863	66	15	of	of	ADP
afs-72863	66	16	different	different	ADJ
afs-72863	66	17	lab	lab	NOUN
afs-72863	66	18	.	.	PUNCT
afs-72863	67	1	to	to	PART
afs-72863	67	2	control	control	VERB
afs-72863	67	3	cell	cell	NOUN
afs-72863	67	4	lysis	lysis	NOUN
afs-72863	67	5	,	,	PUNCT
afs-72863	67	6	and	and	CCONJ
afs-72863	67	7	thus	thus	ADV
afs-72863	67	8	to	to	PART
afs-72863	67	9	release	release	VERB
afs-72863	67	10	peptidases	peptidase	NOUN
afs-72863	67	11	,	,	PUNCT
afs-72863	67	12	we	we	PRON
afs-72863	67	13	have	have	AUX
afs-72863	67	14	isolated	isolate	VERB
afs-72863	67	15	and	and	CCONJ
afs-72863	67	16	characterised	characterise	VERB
afs-72863	67	17	a	a	DET
afs-72863	67	18	stress	stress	NOUN
afs-72863	67	19	(	(	PUNCT
afs-72863	67	20	e.g.	e.g.	ADV
afs-72863	67	21	nacl	nacl	NOUN
afs-72863	67	22	)	)	PUNCT
afs-72863	67	23	induced	induced	ADJ
afs-72863	67	24	promoter	promoter	NOUN
afs-72863	67	25	from	from	ADP
afs-72863	67	26	l.	l.	PROPN
afs-72863	67	27	helveticus	helveticus	PROPN
afs-72863	67	28	(	(	PUNCT
afs-72863	67	29	smeds	smed	NOUN
afs-72863	67	30	et	et	PROPN
afs-72863	67	31	al	al	PROPN
afs-72863	67	32	.	.	PROPN
afs-72863	67	33	,	,	PUNCT
afs-72863	67	34	unpublished	unpublished	ADJ
afs-72863	67	35	)	)	PUNCT
afs-72863	67	36	.	.	PUNCT
afs-72863	68	1	in	in	ADP
afs-72863	68	2	the	the	DET
afs-72863	68	3	next	next	ADJ
afs-72863	68	4	sections	section	NOUN
afs-72863	68	5	i	i	PRON
afs-72863	68	6	shall	shall	AUX
afs-72863	68	7	look	look	VERB
afs-72863	68	8	at	at	ADP
afs-72863	68	9	the	the	DET
afs-72863	68	10	results	result	NOUN
afs-72863	68	11	we	we	PRON
afs-72863	68	12	have	have	AUX
afs-72863	68	13	already	already	ADV
afs-72863	68	14	published	publish	VERB
afs-72863	68	15	or	or	CCONJ
afs-72863	68	16	submitted	submit	VERB
afs-72863	68	17	for	for	ADP
afs-72863	68	18	publication	publication	NOUN
afs-72863	68	19	.	.	PUNCT
afs-72863	69	1	general	general	ADJ
afs-72863	69	2	arninopeptidases	arninopeptidase	NOUN
afs-72863	69	3	n	n	CCONJ
afs-72863	69	4	,	,	PUNCT
afs-72863	69	5	c	c	PROPN
afs-72863	69	6	and	and	CCONJ
afs-72863	69	7	d	d	PROPN
afs-72863	69	8	of	of	ADP
afs-72863	69	9	l	l	NOUN
afs-72863	69	10	helveticus	helveticus	PROPN
afs-72863	69	11	53/7	53/7	NUM
afs-72863	69	12	arninopeptidases	arninopeptidase	NOUN
afs-72863	69	13	are	be	AUX
afs-72863	69	14	capable	capable	ADJ
afs-72863	69	15	of	of	ADP
afs-72863	69	16	cleaving	cleave	VERB
afs-72863	69	17	n	n	CCONJ
afs-72863	69	18	-	-	PUNCT
afs-72863	69	19	terminal	terminal	ADJ
afs-72863	69	20	amino	amino	NOUN
afs-72863	69	21	acids	acid	NOUN
afs-72863	69	22	from	from	ADP
afs-72863	69	23	a	a	DET
afs-72863	69	24	wide	wide	ADJ
afs-72863	69	25	variety	variety	NOUN
afs-72863	69	26	of	of	ADP
afs-72863	69	27	peptides	peptide	NOUN
afs-72863	69	28	differing	differ	VERB
afs-72863	69	29	in	in	ADP
afs-72863	69	30	both	both	DET
afs-72863	69	31	size	size	NOUN
afs-72863	69	32	and	and	CCONJ
afs-72863	69	33	composition	composition	NOUN
afs-72863	69	34	.	.	PUNCT
afs-72863	70	1	the	the	DET
afs-72863	70	2	general	general	ADJ
afs-72863	70	3	arninopeptidases	arninopeptidase	NOUN
afs-72863	70	4	we	we	PRON
afs-72863	70	5	have	have	AUX
afs-72863	70	6	characterised	characterise	VERB
afs-72863	70	7	from	from	ADP
afs-72863	70	8	l.	l.	PROPN
afs-72863	70	9	helveticus	helveticus	PROPN
afs-72863	70	10	53/7	53/7	NUM
afs-72863	70	11	include	include	VERB
afs-72863	70	12	pepn	pepn	NOUN
afs-72863	70	13	and	and	CCONJ
afs-72863	70	14	pepc	pepc	NOUN
afs-72863	70	15	,	,	PUNCT
afs-72863	70	16	which	which	PRON
afs-72863	70	17	hydrolyse	hydrolyse	VERB
afs-72863	70	18	longer	long	ADJ
afs-72863	70	19	peptides	peptide	NOUN
afs-72863	70	20	,	,	PUNCT
afs-72863	70	21	and	and	CCONJ
afs-72863	70	22	a	a	DET
afs-72863	70	23	dipeptidase	dipeptidase	ADJ
afs-72863	70	24	(	(	PUNCT
afs-72863	70	25	pepd	pepd	NOUN
afs-72863	70	26	)	)	PUNCT
afs-72863	70	27	.	.	PUNCT
afs-72863	71	1	fig	fig	NOUN
afs-72863	71	2	.	.	PUNCT
afs-72863	72	1	1.schematic	1.schematic	NUM
afs-72863	72	2	presentation	presentation	NOUN
afs-72863	72	3	of	of	ADP
afs-72863	72	4	the	the	DET
afs-72863	72	5	proteolytic	proteolytic	ADJ
afs-72863	72	6	system	system	NOUN
afs-72863	72	7	in	in	ADP
afs-72863	72	8	lactic	lactic	ADJ
afs-72863	72	9	acid	acid	NOUN
afs-72863	72	10	bacteria	bacteria	NOUN
afs-72863	72	11	.	.	PUNCT
afs-72863	73	1	(	(	PUNCT
afs-72863	73	2	drawn	draw	VERB
afs-72863	73	3	by	by	ADP
afs-72863	73	4	kirsi	kirsi	PROPN
afs-72863	73	5	savijoki	savijoki	NOUN
afs-72863	73	6	)	)	PUNCT
afs-72863	73	7	.	.	PUNCT
afs-72863	74	1	270	270	NUM
afs-72863	74	2	seminar	seminar	NOUN
afs-72863	74	3	in	in	ADP
afs-72863	74	4	honour	honour	NOUN
afs-72863	74	5	of	of	ADP
afs-72863	74	6	the	the	DET
afs-72863	74	7	looth	looth	ADJ
afs-72863	74	8	anniversary	anniversary	NOUN
afs-72863	74	9	ofmtt	ofmtt	VERB
afs-72863	74	10	agricultural	agricultural	ADJ
afs-72863	74	11	and	and	CCONJ
afs-72863	74	12	food	food	NOUN
afs-72863	74	13	science	science	NOUN
afs-72863	74	14	in	in	ADP
afs-72863	74	15	finland	finland	PROPN
afs-72863	74	16	we	we	PRON
afs-72863	74	17	(	(	PUNCT
afs-72863	74	18	varmanen	varmanen	VERB
afs-72863	74	19	et	et	PROPN
afs-72863	74	20	al	al	PROPN
afs-72863	74	21	.	.	PROPN
afs-72863	74	22	1994	1994	NUM
afs-72863	74	23	)	)	PUNCT
afs-72863	74	24	cloned	clone	VERB
afs-72863	74	25	the	the	DET
afs-72863	74	26	aminopeptidase	aminopeptidase	NOUN
afs-72863	74	27	n	n	NOUN
afs-72863	74	28	gene	gene	NOUN
afs-72863	74	29	using	use	VERB
afs-72863	74	30	nucleic	nucleic	ADJ
afs-72863	74	31	acid	acid	NOUN
afs-72863	74	32	hybridisation	hybridisation	NOUN
afs-72863	74	33	to	to	PART
afs-72863	74	34	detect	detect	VERB
afs-72863	74	35	the	the	DET
afs-72863	74	36	pepn	pepn	NOUN
afs-72863	74	37	gene	gene	VERB
afs-72863	74	38	from	from	ADP
afs-72863	74	39	a	a	DET
afs-72863	74	40	l.	l.	PROPN
afs-72863	74	41	helveticus	helveticus	NOUN
afs-72863	74	42	53/7	53/7	NUM
afs-72863	74	43	genomic	genomic	NOUN
afs-72863	74	44	library	library	NOUN
afs-72863	74	45	,	,	PUNCT
afs-72863	74	46	with	with	ADP
afs-72863	74	47	a	a	DET
afs-72863	74	48	fragment	fragment	NOUN
afs-72863	74	49	of	of	ADP
afs-72863	74	50	the	the	DET
afs-72863	74	51	putative	putative	ADJ
afs-72863	74	52	pepn	pepn	NOUN
afs-72863	74	53	gene	gene	VERB
afs-72863	74	54	from	from	ADP
afs-72863	74	55	l.	l.	PROPN
afs-72863	74	56	helveticus	helveticus	PROPN
afs-72863	74	57	cnrz32	cnrz32	NOUN
afs-72863	74	58	(	(	PUNCT
afs-72863	74	59	nowakowski	nowakowski	PROPN
afs-72863	74	60	et	et	PROPN
afs-72863	74	61	al	al	PROPN
afs-72863	74	62	.	.	PROPN
afs-72863	74	63	1993	1993	NUM
afs-72863	74	64	)	)	PUNCT
afs-72863	74	65	as	as	ADP
afs-72863	74	66	the	the	DET
afs-72863	74	67	probe	probe	NOUN
afs-72863	74	68	.	.	PUNCT
afs-72863	75	1	a	a	DET
afs-72863	75	2	3.7	3.7	NUM
afs-72863	75	3	kb	kb	PROPN
afs-72863	75	4	hybridisation	hybridisation	NOUN
afs-72863	75	5	positive	positive	ADJ
afs-72863	75	6	insert	insert	NOUN
afs-72863	75	7	directing	direct	VERB
afs-72863	75	8	aminopeptidase	aminopeptidase	NOUN
afs-72863	75	9	activity	activity	NOUN
afs-72863	75	10	in	in	ADP
afs-72863	75	11	e.	e.	PROPN
afs-72863	75	12	coli	coli	PROPN
afs-72863	75	13	was	be	AUX
afs-72863	75	14	sequenced	sequence	VERB
afs-72863	75	15	and	and	CCONJ
afs-72863	75	16	found	find	VERB
afs-72863	75	17	to	to	PART
afs-72863	75	18	contain	contain	VERB
afs-72863	75	19	only	only	ADV
afs-72863	75	20	one	one	NUM
afs-72863	75	21	open	open	ADJ
afs-72863	75	22	reading	reading	NOUN
afs-72863	75	23	frame	frame	NOUN
afs-72863	75	24	(	(	PUNCT
afs-72863	75	25	orf	orf	PROPN
afs-72863	75	26	)	)	PUNCT
afs-72863	75	27	of	of	ADP
afs-72863	75	28	2532	2532	NUM
afs-72863	75	29	bp	bp	NOUN
afs-72863	75	30	.	.	PUNCT
afs-72863	76	1	this	this	DET
afs-72863	76	2	orf	orf	PROPN
afs-72863	76	3	had	have	VERB
afs-72863	76	4	a	a	DET
afs-72863	76	5	coding	code	VERB
afs-72863	76	6	capacity	capacity	NOUN
afs-72863	76	7	for	for	ADP
afs-72863	76	8	a	a	DET
afs-72863	76	9	95.8	95.8	NUM
afs-72863	76	10	kda	kda	NOUN
afs-72863	76	11	protein	protein	NOUN
afs-72863	76	12	that	that	PRON
afs-72863	76	13	corresponded	correspond	VERB
afs-72863	76	14	to	to	ADP
afs-72863	76	15	the	the	DET
afs-72863	76	16	size	size	NOUN
afs-72863	76	17	of	of	ADP
afs-72863	76	18	the	the	DET
afs-72863	76	19	lactococcal	lactococcal	ADJ
afs-72863	76	20	(	(	PUNCT
afs-72863	76	21	tan	tan	NOUN
afs-72863	76	22	et	et	PROPN
afs-72863	76	23	al	al	PROPN
afs-72863	76	24	.	.	PROPN
afs-72863	76	25	1992	1992	NUM
afs-72863	76	26	)	)	PUNCT
afs-72863	76	27	and	and	CCONJ
afs-72863	76	28	l.	l.	PROPN
afs-72863	76	29	delbrueckii	delbrueckii	PROPN
afs-72863	76	30	subsp	subsp	PROPN
afs-72863	76	31	.	.	PUNCT
afs-72863	77	1	lactis	lactis	PROPN
afs-72863	77	2	pepns	pepns	PROPN
afs-72863	77	3	(	(	PUNCT
afs-72863	77	4	klein	klein	PROPN
afs-72863	77	5	et	et	PROPN
afs-72863	77	6	al	al	PROPN
afs-72863	77	7	.	.	PROPN
afs-72863	77	8	1993	1993	NUM
afs-72863	77	9	)	)	PUNCT
afs-72863	77	10	.	.	PUNCT
afs-72863	78	1	the	the	DET
afs-72863	78	2	deduced	deduce	VERB
afs-72863	78	3	amino	amino	NOUN
afs-72863	78	4	acid	acid	NOUN
afs-72863	78	5	sequence	sequence	NOUN
afs-72863	78	6	was	be	AUX
afs-72863	78	7	49	49	NUM
afs-72863	78	8	%	%	NOUN
afs-72863	78	9	homologous	homologous	ADJ
afs-72863	78	10	to	to	ADP
afs-72863	78	11	lactococcus	lactococcus	PROPN
afs-72863	78	12	lactis	lactis	PROPN
afs-72863	78	13	pepn	pepn	NOUN
afs-72863	78	14	,	,	PUNCT
afs-72863	78	15	and	and	CCONJ
afs-72863	78	16	showed	show	VERB
afs-72863	78	17	99	99	NUM
afs-72863	78	18	%	%	NOUN
afs-72863	78	19	identity	identity	NOUN
afs-72863	78	20	to	to	ADP
afs-72863	78	21	the	the	DET
afs-72863	78	22	l.	l.	PROPN
afs-72863	78	23	helveticus	helveticus	PROPN
afs-72863	78	24	cnrz32	cnrz32	NOUN
afs-72863	78	25	pepn	pepn	PROPN
afs-72863	78	26	gene	gene	VERB
afs-72863	78	27	,	,	PUNCT
afs-72863	78	28	sequenced	sequence	VERB
afs-72863	78	29	later	later	ADV
afs-72863	78	30	,	,	PUNCT
afs-72863	78	31	(	(	PUNCT
afs-72863	78	32	christensen	christensen	PROPN
afs-72863	78	33	et	et	PROPN
afs-72863	78	34	al	al	PROPN
afs-72863	78	35	.	.	PROPN
afs-72863	78	36	1995	1995	NUM
afs-72863	78	37	)	)	PUNCT
afs-72863	78	38	.	.	PUNCT
afs-72863	79	1	furthermore	furthermore	ADV
afs-72863	79	2	,	,	PUNCT
afs-72863	79	3	the	the	DET
afs-72863	79	4	conserved	conserved	ADJ
afs-72863	79	5	catalytic	catalytic	ADJ
afs-72863	79	6	and	and	CCONJ
afs-72863	79	7	zinc	zinc	NOUN
afs-72863	79	8	-	-	PUNCT
afs-72863	79	9	binding	bind	VERB
afs-72863	79	10	sites	site	NOUN
afs-72863	79	11	of	of	ADP
afs-72863	79	12	the	the	DET
afs-72863	79	13	neutral	neutral	ADJ
afs-72863	79	14	zinc	zinc	NOUN
afs-72863	79	15	metallo	metallo	ADJ
afs-72863	79	16	-	-	PUNCT
afs-72863	79	17	peptidase	peptidase	NOUN
afs-72863	79	18	family	family	NOUN
afs-72863	79	19	were	be	AUX
afs-72863	79	20	identified	identify	VERB
afs-72863	79	21	from	from	ADP
afs-72863	79	22	the	the	DET
afs-72863	79	23	pepn	pepn	NOUN
afs-72863	79	24	sequence	sequence	NOUN
afs-72863	79	25	,	,	PUNCT
afs-72863	79	26	confirming	confirm	VERB
afs-72863	79	27	that	that	SCONJ
afs-72863	79	28	the	the	DET
afs-72863	79	29	orf	orf	PROPN
afs-72863	79	30	cloned	clone	VERB
afs-72863	79	31	and	and	CCONJ
afs-72863	79	32	sequenced	sequence	VERB
afs-72863	79	33	did	do	AUX
afs-72863	79	34	indeed	indeed	ADV
afs-72863	79	35	encode	encode	VERB
afs-72863	79	36	the	the	DET
afs-72863	79	37	aminopeptidase	aminopeptidase	NOUN
afs-72863	79	38	n	n	PRON
afs-72863	79	39	activity	activity	NOUN
afs-72863	79	40	.	.	PUNCT
afs-72863	80	1	the	the	DET
afs-72863	80	2	pepn	pepn	PROPN
afs-72863	80	3	mrna	mrna	PROPN
afs-72863	80	4	analyses	analysis	NOUN
afs-72863	80	5	revealed	reveal	VERB
afs-72863	80	6	2.75	2.75	NUM
afs-72863	80	7	kb	kb	PROPN
afs-72863	80	8	transcripts	transcript	NOUN
afs-72863	80	9	with	with	ADP
afs-72863	80	10	two	two	NUM
afs-72863	80	11	transcription	transcription	NOUN
afs-72863	80	12	start	start	VERB
afs-72863	80	13	sites	site	NOUN
afs-72863	80	14	.	.	PUNCT
afs-72863	81	1	these	these	DET
afs-72863	81	2	two	two	NUM
afs-72863	81	3	sites	site	NOUN
afs-72863	81	4	verified	verify	VERB
afs-72863	81	5	the	the	DET
afs-72863	81	6	existence	existence	NOUN
afs-72863	81	7	of	of	ADP
afs-72863	81	8	two	two	NUM
afs-72863	81	9	putative	putative	ADJ
afs-72863	81	10	overlapping	overlap	VERB
afs-72863	81	11	promoter	promoter	NOUN
afs-72863	81	12	regions	region	NOUN
afs-72863	81	13	in	in	ADP
afs-72863	81	14	the	the	DET
afs-72863	81	15	dna	dna	PROPN
afs-72863	81	16	sequence	sequence	NOUN
afs-72863	81	17	.	.	PUNCT
afs-72863	82	1	our	our	PRON
afs-72863	82	2	studies	study	NOUN
afs-72863	82	3	on	on	ADP
afs-72863	82	4	pepn	pepn	NOUN
afs-72863	82	5	expression	expression	NOUN
afs-72863	82	6	as	as	ADP
afs-72863	82	7	a	a	DET
afs-72863	82	8	function	function	NOUN
afs-72863	82	9	of	of	ADP
afs-72863	82	10	growth	growth	NOUN
afs-72863	82	11	in	in	ADP
afs-72863	82	12	a	a	DET
afs-72863	82	13	bioreactor	bioreactor	NOUN
afs-72863	82	14	showed	show	VERB
afs-72863	82	15	thatpepn	thatpepn	ADP
afs-72863	82	16	transcripts	transcript	NOUN
afs-72863	82	17	remained	remain	VERB
afs-72863	82	18	at	at	ADP
afs-72863	82	19	a	a	DET
afs-72863	82	20	high	high	ADJ
afs-72863	82	21	level	level	NOUN
afs-72863	82	22	during	during	ADP
afs-72863	82	23	the	the	DET
afs-72863	82	24	stationary	stationary	ADJ
afs-72863	82	25	growth	growth	NOUN
afs-72863	82	26	phase	phase	NOUN
afs-72863	82	27	,	,	PUNCT
afs-72863	82	28	too	too	ADV
afs-72863	82	29	,	,	PUNCT
afs-72863	82	30	in	in	ADP
afs-72863	82	31	contrast	contrast	NOUN
afs-72863	82	32	to	to	ADP
afs-72863	82	33	the	the	DET
afs-72863	82	34	steady	steady	ADJ
afs-72863	82	35	-	-	PUNCT
afs-72863	82	36	state	state	NOUN
afs-72863	82	37	levels	level	NOUN
afs-72863	82	38	of	of	ADP
afs-72863	82	39	all	all	DET
afs-72863	82	40	other	other	ADJ
afs-72863	82	41	peptidase	peptidase	NOUN
afs-72863	82	42	mrnas	mrna	NOUN
afs-72863	82	43	we	we	PRON
afs-72863	82	44	have	have	AUX
afs-72863	82	45	analysed	analyse	VERB
afs-72863	82	46	.	.	PUNCT
afs-72863	83	1	similarly	similarly	ADV
afs-72863	83	2	,	,	PUNCT
afs-72863	83	3	the	the	DET
afs-72863	83	4	level	level	NOUN
afs-72863	83	5	of	of	ADP
afs-72863	83	6	total	total	ADJ
afs-72863	83	7	aminopeptidase	aminopeptidase	NOUN
afs-72863	83	8	activity	activity	NOUN
afs-72863	83	9	remained	remain	VERB
afs-72863	83	10	constant	constant	ADJ
afs-72863	83	11	throughout	throughout	ADP
afs-72863	83	12	the	the	DET
afs-72863	83	13	stationary	stationary	ADJ
afs-72863	83	14	growth	growth	NOUN
afs-72863	83	15	phase	phase	NOUN
afs-72863	83	16	.	.	PUNCT
afs-72863	84	1	the	the	DET
afs-72863	84	2	inhibition	inhibition	NOUN
afs-72863	84	3	profiles	profile	NOUN
afs-72863	84	4	of	of	ADP
afs-72863	84	5	pepn	pepn	NOUN
afs-72863	84	6	showed	show	VERB
afs-72863	84	7	that	that	SCONJ
afs-72863	84	8	it	it	PRON
afs-72863	84	9	is	be	AUX
afs-72863	84	10	indeed	indeed	ADV
afs-72863	84	11	a	a	DET
afs-72863	84	12	zinc	zinc	NOUN
afs-72863	84	13	-	-	PUNCT
afs-72863	84	14	dependent	dependent	ADJ
afs-72863	84	15	metallopeptidase	metallopeptidase	NOUN
afs-72863	84	16	,	,	PUNCT
afs-72863	84	17	being	be	AUX
afs-72863	84	18	completely	completely	ADV
afs-72863	84	19	inhibited	inhibit	VERB
afs-72863	84	20	by	by	ADP
afs-72863	84	21	ethylenediaminetetra	ethylenediaminetetra	ADJ
afs-72863	84	22	-	-	ADJ
afs-72863	84	23	acetic	acetic	ADJ
afs-72863	84	24	acid	acid	NOUN
afs-72863	84	25	(	(	PUNCT
afs-72863	84	26	edta	edta	NOUN
afs-72863	84	27	)	)	PUNCT
afs-72863	84	28	whereas	whereas	SCONJ
afs-72863	84	29	serine	serine	ADJ
afs-72863	84	30	protease	protease	NOUN
afs-72863	84	31	inhibitor	inhibitor	NOUN
afs-72863	84	32	phenylmethylsulphonylfluoride	phenylmethylsulphonylfluoride	NOUN
afs-72863	84	33	(	(	PUNCT
afs-72863	84	34	pmsf	pmsf	NOUN
afs-72863	84	35	)	)	PUNCT
afs-72863	84	36	and	and	CCONJ
afs-72863	84	37	a	a	DET
afs-72863	84	38	thiolblocking	thiolblocking	ADJ
afs-72863	84	39	reagent	reagent	NOUN
afs-72863	84	40	,	,	PUNCT
afs-72863	84	41	p	p	NOUN
afs-72863	84	42	-	-	PUNCT
afs-72863	84	43	hydroxymercuribenzoate	hydroxymercuribenzoate	NOUN
afs-72863	84	44	(	(	PUNCT
afs-72863	84	45	phmb	phmb	NOUN
afs-72863	84	46	)	)	PUNCT
afs-72863	84	47	,	,	PUNCT
afs-72863	84	48	had	have	VERB
afs-72863	84	49	only	only	ADV
afs-72863	84	50	a	a	DET
afs-72863	84	51	slight	slight	ADJ
afs-72863	84	52	effect	effect	NOUN
afs-72863	84	53	on	on	ADP
afs-72863	84	54	enzyme	enzyme	NOUN
afs-72863	84	55	activity	activity	NOUN
afs-72863	84	56	(	(	PUNCT
afs-72863	84	57	varmanen	varmanen	NOUN
afs-72863	84	58	et	et	PROPN
afs-72863	84	59	al	al	PROPN
afs-72863	84	60	.	.	PROPN
afs-72863	84	61	1994	1994	NUM
afs-72863	84	62	)	)	PUNCT
afs-72863	84	63	.	.	PUNCT
afs-72863	85	1	thus	thus	ADV
afs-72863	85	2	,	,	PUNCT
afs-72863	85	3	the	the	DET
afs-72863	85	4	characteristics	characteristic	NOUN
afs-72863	85	5	ofl	ofl	PROPN
afs-72863	85	6	.	.	PUNCT
afs-72863	86	1	helveticus	helveticus	PROPN
afs-72863	86	2	pepn	pepn	NOUN
afs-72863	86	3	are	be	AUX
afs-72863	86	4	in	in	ADP
afs-72863	86	5	accordance	accordance	NOUN
afs-72863	86	6	with	with	ADP
afs-72863	86	7	pepns	pepns	NOUN
afs-72863	86	8	from	from	ADP
afs-72863	86	9	other	other	ADJ
afs-72863	86	10	lab	lab	NOUN
afs-72863	86	11	(	(	PUNCT
afs-72863	86	12	kunji	kunji	X
afs-72863	86	13	et	et	PROPN
afs-72863	86	14	al	al	PROPN
afs-72863	86	15	.	.	PROPN
afs-72863	86	16	1996	1996	NUM
afs-72863	86	17	)	)	PUNCT
afs-72863	86	18	.	.	PUNCT
afs-72863	87	1	the	the	DET
afs-72863	87	2	second	second	ADJ
afs-72863	87	3	aminopeptidase	aminopeptidase	NOUN
afs-72863	87	4	we	we	PRON
afs-72863	87	5	characterised	characterise	VERB
afs-72863	87	6	was	be	AUX
afs-72863	87	7	the	the	DET
afs-72863	87	8	pepc	pepc	NOUN
afs-72863	87	9	(	(	PUNCT
afs-72863	87	10	vesanto	vesanto	ADP
afs-72863	87	11	et	et	PROPN
afs-72863	87	12	al	al	PROPN
afs-72863	87	13	.	.	PROPN
afs-72863	87	14	1994	1994	NUM
afs-72863	87	15	)	)	PUNCT
afs-72863	87	16	.	.	PUNCT
afs-72863	88	1	the	the	DET
afs-72863	88	2	isolation	isolation	NOUN
afs-72863	88	3	procedure	procedure	NOUN
afs-72863	88	4	for	for	ADP
afs-72863	88	5	the	the	DET
afs-72863	88	6	pepc	pepc	NOUN
afs-72863	88	7	gene	gene	NOUN
afs-72863	88	8	was	be	AUX
afs-72863	88	9	similar	similar	ADJ
afs-72863	88	10	to	to	ADP
afs-72863	88	11	that	that	PRON
afs-72863	88	12	for	for	ADP
afs-72863	88	13	pepn	pepn	NOUN
afs-72863	88	14	.	.	PUNCT
afs-72863	89	1	in	in	ADP
afs-72863	89	2	a	a	DET
afs-72863	89	3	hybridisation	hybridisation	NOUN
afs-72863	89	4	positive	positive	ADJ
afs-72863	89	5	clone	clone	NOUN
afs-72863	89	6	showing	show	VERB
afs-72863	89	7	aminopeptidase	aminopeptidase	NOUN
afs-72863	89	8	activity	activity	NOUN
afs-72863	89	9	the	the	DET
afs-72863	89	10	pepc	pepc	NOUN
afs-72863	89	11	gene	gene	NOUN
afs-72863	89	12	could	could	AUX
afs-72863	89	13	be	be	AUX
afs-72863	89	14	localised	localise	VERB
afs-72863	89	15	into	into	ADP
afs-72863	89	16	a	a	DET
afs-72863	89	17	3	3	NUM
afs-72863	89	18	kb	kb	X
afs-72863	89	19	fragment	fragment	NOUN
afs-72863	89	20	by	by	ADP
afs-72863	89	21	deletion	deletion	NOUN
afs-72863	89	22	mapping	mapping	NOUN
afs-72863	89	23	.	.	PUNCT
afs-72863	90	1	sequencing	sequence	VERB
afs-72863	90	2	of	of	ADP
afs-72863	90	3	this	this	DET
afs-72863	90	4	fragment	fragment	NOUN
afs-72863	90	5	revealed	reveal	VERB
afs-72863	90	6	two	two	NUM
afs-72863	90	7	open	open	ADJ
afs-72863	90	8	reading	reading	NOUN
afs-72863	90	9	frames	frame	NOUN
afs-72863	90	10	(	(	PUNCT
afs-72863	90	11	orfi	orfi	NOUN
afs-72863	90	12	and	and	CCONJ
afs-72863	90	13	orf2	orf2	NOUN
afs-72863	90	14	)	)	PUNCT
afs-72863	90	15	of	of	ADP
afs-72863	90	16	1347	1347	NUM
afs-72863	90	17	and	and	CCONJ
afs-72863	90	18	840	840	NUM
afs-72863	90	19	bp	bp	PROPN
afs-72863	90	20	.	.	PUNCT
afs-72863	91	1	orfi	orfi	PROPN
afs-72863	91	2	was	be	AUX
afs-72863	91	3	preceded	precede	VERB
afs-72863	91	4	by	by	ADP
afs-72863	91	5	a	a	DET
afs-72863	91	6	typical	typical	ADJ
afs-72863	91	7	prokaryotic	prokaryotic	ADJ
afs-72863	91	8	promoter	promoter	NOUN
afs-72863	91	9	region	region	NOUN
afs-72863	91	10	,	,	PUNCT
afs-72863	91	11	and	and	CCONJ
afs-72863	91	12	an	an	DET
afs-72863	91	13	inverted	inverted	ADJ
afs-72863	91	14	repeat	repeat	NOUN
afs-72863	91	15	structure	structure	NOUN
afs-72863	91	16	with	with	ADP
afs-72863	91	17	delta	delta	PROPN
afs-72863	91	18	g	g	PROPN
afs-72863	91	19	of	of	ADP
afs-72863	91	20	-49.0	-49.0	PROPN
afs-72863	91	21	kjmol	kjmol	NOUN
afs-72863	91	22	'	'	PART
afs-72863	91	23	1	1	NUM
afs-72863	91	24	was	be	AUX
afs-72863	91	25	found	find	VERB
afs-72863	91	26	downstream	downstream	ADJ
afs-72863	91	27	of	of	ADP
afs-72863	91	28	the	the	DET
afs-72863	91	29	coding	code	VERB
afs-72863	91	30	region	region	NOUN
afs-72863	91	31	.	.	PUNCT
afs-72863	92	1	the	the	DET
afs-72863	92	2	deduced	deduce	VERB
afs-72863	92	3	amino	amino	NOUN
afs-72863	92	4	acid	acid	NOUN
afs-72863	92	5	sequence	sequence	NOUN
afs-72863	92	6	of	of	ADP
afs-72863	92	7	orfi	orfi	NOUN
afs-72863	92	8	,	,	PUNCT
afs-72863	92	9	with	with	ADP
afs-72863	92	10	an	an	DET
afs-72863	92	11	encoding	encoding	NOUN
afs-72863	92	12	capacity	capacity	NOUN
afs-72863	92	13	of	of	ADP
afs-72863	92	14	a	a	DET
afs-72863	92	15	51.4	51.4	NUM
afs-72863	92	16	kda	kda	NOUN
afs-72863	92	17	protein	protein	NOUN
afs-72863	92	18	,	,	PUNCT
afs-72863	92	19	shared	share	VERB
afs-72863	92	20	48.3	48.3	NUM
afs-72863	92	21	%	%	NOUN
afs-72863	92	22	and	and	CCONJ
afs-72863	92	23	98	98	NUM
afs-72863	92	24	%	%	NOUN
afs-72863	92	25	identity	identity	NOUN
afs-72863	92	26	with	with	ADP
afs-72863	92	27	the	the	DET
afs-72863	92	28	pepc	pepc	NOUN
afs-72863	92	29	proteins	protein	NOUN
afs-72863	92	30	from	from	ADP
afs-72863	92	31	lactococcus	lactococcus	PROPN
afs-72863	92	32	lactis	lactis	PROPN
afs-72863	92	33	(	(	PUNCT
afs-72863	92	34	chapotchartier	chapotchartier	ADV
afs-72863	92	35	et	et	PROPN
afs-72863	92	36	al	al	PROPN
afs-72863	92	37	.	.	PROPN
afs-72863	92	38	1993	1993	NUM
afs-72863	92	39	)	)	PUNCT
afs-72863	92	40	and	and	CCONJ
afs-72863	92	41	l.	l.	PROPN
afs-72863	92	42	helveticus	helveticus	PROPN
afs-72863	92	43	cnrz32	cnrz32	NOUN
afs-72863	92	44	(	(	PUNCT
afs-72863	92	45	fernändez	fernändez	PROPN
afs-72863	92	46	et	et	PROPN
afs-72863	92	47	al	al	PROPN
afs-72863	92	48	.	.	PROPN
afs-72863	92	49	1994	1994	NUM
afs-72863	92	50	)	)	PUNCT
afs-72863	92	51	,	,	PUNCT
afs-72863	92	52	thus	thus	ADV
afs-72863	92	53	confirming	confirm	VERB
afs-72863	92	54	that	that	SCONJ
afs-72863	92	55	orfi	orfi	NOUN
afs-72863	92	56	codes	code	NOUN
afs-72863	92	57	for	for	ADP
afs-72863	92	58	an	an	DET
afs-72863	92	59	aminopeptidase	aminopeptidase	NOUN
afs-72863	92	60	c.	c.	PROPN
afs-72863	92	61	mrna	mrna	PROPN
afs-72863	92	62	size	size	NOUN
afs-72863	92	63	analyses	analysis	NOUN
afs-72863	92	64	revealed	reveal	VERB
afs-72863	92	65	1.7	1.7	NUM
afs-72863	92	66	and	and	CCONJ
afs-72863	92	67	2.7	2.7	NUM
afs-72863	92	68	kb	kb	PROPN
afs-72863	92	69	transcripts	transcript	NOUN
afs-72863	92	70	.	.	PUNCT
afs-72863	93	1	further	further	ADJ
afs-72863	93	2	analysis	analysis	NOUN
afs-72863	93	3	with	with	ADP
afs-72863	93	4	the	the	DET
afs-72863	93	5	pepc	pepc	NOUN
afs-72863	93	6	and	and	CCONJ
afs-72863	93	7	orf	orf	PROPN
afs-72863	93	8	2	2	NUM
afs-72863	93	9	specific	specific	ADJ
afs-72863	93	10	probes	probe	NOUN
afs-72863	93	11	showed	show	VERB
afs-72863	93	12	that	that	SCONJ
afs-72863	93	13	the	the	DET
afs-72863	93	14	downstream	downstream	ADJ
afs-72863	93	15	orf2	orf2	NOUN
afs-72863	93	16	was	be	AUX
afs-72863	93	17	co	co	VERB
afs-72863	93	18	-	-	ADJ
afs-72863	93	19	transcribed	transcribe	VERB
afs-72863	93	20	with	with	ADP
afs-72863	93	21	the	the	DET
afs-72863	93	22	pepc	pepc	NOUN
afs-72863	93	23	gene	gene	NOUN
afs-72863	93	24	at	at	ADP
afs-72863	93	25	the	the	DET
afs-72863	93	26	exponential	exponential	ADJ
afs-72863	93	27	phase	phase	NOUN
afs-72863	93	28	of	of	ADP
afs-72863	93	29	growth	growth	NOUN
afs-72863	93	30	whereas	whereas	SCONJ
afs-72863	93	31	,	,	PUNCT
afs-72863	93	32	at	at	ADP
afs-72863	93	33	the	the	DET
afs-72863	93	34	stationary	stationary	ADJ
afs-72863	93	35	growth	growth	NOUN
afs-72863	93	36	phase	phase	NOUN
afs-72863	93	37	,	,	PUNCT
afs-72863	93	38	pepc	pepc	ADJ
afs-72863	93	39	transcripts	transcript	NOUN
afs-72863	93	40	derived	derive	VERB
afs-72863	93	41	from	from	ADP
afs-72863	93	42	the	the	DET
afs-72863	93	43	pepc	pepc	NOUN
afs-72863	93	44	promoter	promoter	NOUN
afs-72863	93	45	were	be	AUX
afs-72863	93	46	below	below	ADP
afs-72863	93	47	the	the	DET
afs-72863	93	48	detection	detection	NOUN
afs-72863	93	49	limit	limit	NOUN
afs-72863	93	50	and	and	CCONJ
afs-72863	93	51	orf2	orf2	NOUN
afs-72863	93	52	was	be	AUX
afs-72863	93	53	expressed	express	VERB
afs-72863	93	54	by	by	ADP
afs-72863	93	55	its	its	PRON
afs-72863	93	56	own	own	ADJ
afs-72863	93	57	promoter	promoter	NOUN
afs-72863	93	58	(	(	PUNCT
afs-72863	93	59	vesanto	vesanto	ADP
afs-72863	93	60	et	et	PROPN
afs-72863	93	61	al	al	PROPN
afs-72863	93	62	.	.	PROPN
afs-72863	93	63	1994	1994	NUM
afs-72863	93	64	)	)	PUNCT
afs-72863	93	65	.	.	PUNCT
afs-72863	94	1	the	the	DET
afs-72863	94	2	5	5	NUM
afs-72863	94	3	’	'	PUNCT
afs-72863	94	4	end	end	NOUN
afs-72863	94	5	mapping	mapping	NOUN
afs-72863	94	6	of	of	ADP
afs-72863	94	7	the	the	DET
afs-72863	94	8	pepc	pepc	NOUN
afs-72863	94	9	transcripts	transcript	NOUN
afs-72863	94	10	revealed	reveal	VERB
afs-72863	94	11	a	a	DET
afs-72863	94	12	transcription	transcription	NOUN
afs-72863	94	13	start	start	VERB
afs-72863	94	14	different	different	ADJ
afs-72863	94	15	from	from	ADP
afs-72863	94	16	that	that	PRON
afs-72863	94	17	suggested	suggest	VERB
afs-72863	94	18	for	for	ADP
afs-72863	94	19	the	the	DET
afs-72863	94	20	pepc	pepc	NOUN
afs-72863	94	21	in	in	ADP
afs-72863	94	22	the	the	DET
afs-72863	94	23	l.	l.	PROPN
afs-72863	94	24	helveticus	helveticus	PROPN
afs-72863	94	25	cnrz32	cnrz32	NOUN
afs-72863	94	26	pepc	pepc	NOUN
afs-72863	94	27	gene	gene	NOUN
afs-72863	94	28	(	(	PUNCT
afs-72863	94	29	fernandez	fernandez	PROPN
afs-72863	94	30	et	et	PROPN
afs-72863	94	31	al	al	PROPN
afs-72863	94	32	.	.	PROPN
afs-72863	94	33	1994	1994	NUM
afs-72863	94	34	)	)	PUNCT
afs-72863	94	35	.	.	PUNCT
afs-72863	95	1	we	we	PRON
afs-72863	95	2	also	also	ADV
afs-72863	95	3	studied	study	VERB
afs-72863	95	4	expression	expression	NOUN
afs-72863	95	5	of	of	ADP
afs-72863	95	6	pepc	pepc	NOUN
afs-72863	95	7	in	in	ADP
afs-72863	95	8	l.	l.	PROPN
afs-72863	95	9	helveticus	helveticus	PROPN
afs-72863	95	10	as	as	ADP
afs-72863	95	11	a	a	DET
afs-72863	95	12	function	function	NOUN
afs-72863	95	13	of	of	ADP
afs-72863	95	14	growth	growth	NOUN
afs-72863	95	15	in	in	ADP
afs-72863	95	16	a	a	DET
afs-72863	95	17	bioreactor	bioreactor	NOUN
afs-72863	95	18	cultivation	cultivation	NOUN
afs-72863	95	19	,	,	PUNCT
afs-72863	95	20	and	and	CCONJ
afs-72863	95	21	found	find	VERB
afs-72863	95	22	that	that	SCONJ
afs-72863	95	23	transcription	transcription	NOUN
afs-72863	95	24	of	of	ADP
afs-72863	95	25	pepc	pepc	NOUN
afs-72863	95	26	was	be	AUX
afs-72863	95	27	typical	typical	ADJ
afs-72863	95	28	of	of	ADP
afs-72863	95	29	the	the	DET
afs-72863	95	30	exponential	exponential	ADJ
afs-72863	95	31	growth	growth	NOUN
afs-72863	95	32	phase	phase	NOUN
afs-72863	95	33	expression	expression	NOUN
afs-72863	95	34	.	.	PUNCT
afs-72863	96	1	the	the	DET
afs-72863	96	2	level	level	NOUN
afs-72863	96	3	of	of	ADP
afs-72863	96	4	total	total	ADJ
afs-72863	96	5	thiolaminopeptidase	thiolaminopeptidase	NOUN
afs-72863	96	6	activity	activity	NOUN
afs-72863	96	7	,	,	PUNCT
afs-72863	96	8	however	however	ADV
afs-72863	96	9	,	,	PUNCT
afs-72863	96	10	remained	remain	VERB
afs-72863	96	11	nearly	nearly	ADV
afs-72863	96	12	constant	constant	ADJ
afs-72863	96	13	throughout	throughout	ADP
afs-72863	96	14	the	the	DET
afs-72863	96	15	stationary	stationary	ADJ
afs-72863	96	16	growth	growth	NOUN
afs-72863	96	17	phase	phase	NOUN
afs-72863	96	18	.	.	PUNCT
afs-72863	97	1	strain	strain	PROPN
afs-72863	97	2	53/7	53/7	NUM
afs-72863	97	3	pepc	pepc	NOUN
afs-72863	97	4	expressed	express	VERB
afs-72863	97	5	in	in	ADP
afs-72863	97	6	e.	e.	PROPN
afs-72863	97	7	coli	coli	PROPN
afs-72863	97	8	could	could	AUX
afs-72863	97	9	be	be	AUX
afs-72863	97	10	completely	completely	ADV
afs-72863	97	11	inhibited	inhibit	VERB
afs-72863	97	12	by	by	ADP
afs-72863	97	13	phmb	phmb	NOUN
afs-72863	97	14	and	and	CCONJ
afs-72863	97	15	partially	partially	ADV
afs-72863	97	16	by	by	ADP
afs-72863	97	17	pmsf	pmsf	NOUN
afs-72863	97	18	whereas	whereas	SCONJ
afs-72863	97	19	edta	edta	NOUN
afs-72863	97	20	had	have	VERB
afs-72863	97	21	only	only	ADV
afs-72863	97	22	a	a	DET
afs-72863	97	23	minor	minor	ADJ
afs-72863	97	24	effect	effect	NOUN
afs-72863	97	25	.	.	PUNCT
afs-72863	98	1	thus	thus	ADV
afs-72863	98	2	,	,	PUNCT
afs-72863	98	3	pepc	pepc	PROPN
afs-72863	98	4	is	be	AUX
afs-72863	98	5	a	a	DET
afs-72863	98	6	thioldependent	thioldependent	NOUN
afs-72863	98	7	aminopeptidase	aminopeptidase	NOUN
afs-72863	98	8	belonging	belong	VERB
afs-72863	98	9	to	to	ADP
afs-72863	98	10	the	the	DET
afs-72863	98	11	cysteine	cysteine	NOUN
afs-72863	98	12	proteinase	proteinase	NOUN
afs-72863	98	13	family	family	NOUN
afs-72863	98	14	.	.	PUNCT
afs-72863	99	1	this	this	PRON
afs-72863	99	2	allowed	allow	VERB
afs-72863	99	3	a	a	DET
afs-72863	99	4	rough	rough	ADJ
afs-72863	99	5	estimationof	estimationof	NOUN
afs-72863	99	6	the	the	DET
afs-72863	99	7	contributions	contribution	NOUN
afs-72863	99	8	of	of	ADP
afs-72863	99	9	pepn	pepn	NOUN
afs-72863	99	10	and	and	CCONJ
afs-72863	99	11	pepc	pepc	VERB
afs-72863	99	12	to	to	ADP
afs-72863	99	13	the	the	DET
afs-72863	99	14	total	total	ADJ
afs-72863	99	15	aminopeptidase	aminopeptidase	NOUN
afs-72863	99	16	activity	activity	NOUN
afs-72863	99	17	in	in	ADP
afs-72863	99	18	l.	l.	PROPN
afs-72863	99	19	helveticus	helveticus	PROPN
afs-72863	99	20	.	.	PUNCT
afs-72863	100	1	addition	addition	NOUN
afs-72863	100	2	of	of	ADP
afs-72863	100	3	edta	edta	NOUN
afs-72863	100	4	or	or	CCONJ
afs-72863	100	5	edta	edta	NOUN
afs-72863	100	6	and	and	CCONJ
afs-72863	100	7	phmb	phmb	NOUN
afs-72863	100	8	to	to	ADP
afs-72863	100	9	l.	l.	PROPN
afs-72863	100	10	helveticus	helveticus	PROPN
afs-72863	100	11	cell	cell	NOUN
afs-72863	100	12	lysates	lysate	NOUN
afs-72863	100	13	in	in	ADP
afs-72863	100	14	the	the	DET
afs-72863	100	15	presence	presence	NOUN
afs-72863	100	16	oflysp	oflysp	NOUN
afs-72863	100	17	-	-	PUNCT
afs-72863	100	18	nitroanilide	nitroanilide	ADJ
afs-72863	100	19	(	(	PUNCT
afs-72863	100	20	pna	pna	NOUN
afs-72863	100	21	)	)	PUNCT
afs-72863	100	22	substrate	substrate	NOUN
afs-72863	100	23	reduced	reduce	VERB
afs-72863	100	24	the	the	DET
afs-72863	100	25	ac271	ac271	PROPN
afs-72863	100	26	vol	vol	NOUN
afs-72863	100	27	.	.	PUNCT
afs-72863	101	1	7(1998	7(1998	NUM
afs-72863	101	2	):	):	PUNCT
afs-72863	101	3	267	267	NUM
afs-72863	101	4	-	-	SYM
afs-72863	101	5	282	282	NUM
afs-72863	101	6	.	.	PUNCT
afs-72863	102	1	agricultural	agricultural	ADJ
afs-72863	102	2	and	and	CCONJ
afs-72863	102	3	food	food	NOUN
afs-72863	102	4	science	science	NOUN
afs-72863	102	5	in	in	ADP
afs-72863	102	6	finland	finland	PROPN
afs-72863	102	7	tivity	tivity	NOUN
afs-72863	102	8	to	to	ADP
afs-72863	102	9	10	10	NUM
afs-72863	102	10	%	%	NOUN
afs-72863	102	11	and	and	CCONJ
afs-72863	102	12	to	to	ADP
afs-72863	102	13	below	below	ADP
afs-72863	102	14	the	the	DET
afs-72863	102	15	detection	detection	NOUN
afs-72863	102	16	limit	limit	NOUN
afs-72863	102	17	,	,	PUNCT
afs-72863	102	18	respectively	respectively	ADV
afs-72863	102	19	,	,	PUNCT
afs-72863	102	20	indicating	indicate	VERB
afs-72863	102	21	that	that	SCONJ
afs-72863	102	22	the	the	DET
afs-72863	102	23	aminopeptidase	aminopeptidase	NOUN
afs-72863	102	24	activity	activity	NOUN
afs-72863	102	25	in	in	ADP
afs-72863	102	26	l.	l.	PROPN
afs-72863	102	27	helveticus	helveticus	PROPN
afs-72863	102	28	is	be	AUX
afs-72863	102	29	mainly	mainly	ADV
afs-72863	102	30	due	due	ADJ
afs-72863	102	31	to	to	ADP
afs-72863	102	32	the	the	DET
afs-72863	102	33	metalloaminopeptidase	metalloaminopeptidase	NOUN
afs-72863	102	34	(	(	PUNCT
afs-72863	102	35	varmanen	varmanen	PROPN
afs-72863	102	36	et	et	PROPN
afs-72863	102	37	al	al	PROPN
afs-72863	102	38	.	.	PROPN
afs-72863	102	39	1994	1994	NUM
afs-72863	102	40	)	)	PUNCT
afs-72863	102	41	.	.	PUNCT
afs-72863	103	1	comparison	comparison	NOUN
afs-72863	103	2	of	of	ADP
afs-72863	103	3	the	the	DET
afs-72863	103	4	level	level	NOUN
afs-72863	103	5	ofpepn	ofpepn	NOUN
afs-72863	103	6	and	and	CCONJ
afs-72863	103	7	pepc	pepc	NOUN
afs-72863	103	8	transcripts	transcript	NOUN
afs-72863	103	9	supports	support	VERB
afs-72863	103	10	the	the	DET
afs-72863	103	11	conclusion	conclusion	NOUN
afs-72863	103	12	that	that	SCONJ
afs-72863	103	13	pepn	pepn	PROPN
afs-72863	103	14	is	be	AUX
afs-72863	103	15	the	the	DET
afs-72863	103	16	main	main	ADJ
afs-72863	103	17	aminopeptidase	aminopeptidase	NOUN
afs-72863	103	18	in	in	ADP
afs-72863	103	19	l.	l.	PROPN
afs-72863	103	20	helveticus	helveticus	PROPN
afs-72863	103	21	(	(	PUNCT
afs-72863	103	22	data	datum	NOUN
afs-72863	103	23	not	not	PART
afs-72863	103	24	shown	show	VERB
afs-72863	103	25	)	)	PUNCT
afs-72863	103	26	.	.	PUNCT
afs-72863	104	1	our	our	PRON
afs-72863	104	2	further	further	ADJ
afs-72863	104	3	studies	study	NOUN
afs-72863	104	4	on	on	ADP
afs-72863	104	5	orf2	orf2	NOUN
afs-72863	104	6	have	have	AUX
afs-72863	104	7	revealed	reveal	VERB
afs-72863	104	8	that	that	SCONJ
afs-72863	104	9	it	it	PRON
afs-72863	104	10	codes	code	VERB
afs-72863	104	11	for	for	ADP
afs-72863	104	12	a	a	DET
afs-72863	104	13	transmembrane	transmembrane	ADJ
afs-72863	104	14	protein	protein	NOUN
afs-72863	104	15	homologous	homologous	ADJ
afs-72863	104	16	to	to	ADP
afs-72863	104	17	an	an	DET
afs-72863	104	18	unknown	unknown	ADJ
afs-72863	104	19	bacillus	bacillus	NOUN
afs-72863	104	20	protein	protein	NOUN
afs-72863	104	21	that	that	PRON
afs-72863	104	22	is	be	AUX
afs-72863	104	23	expressed	express	VERB
afs-72863	104	24	during	during	ADP
afs-72863	104	25	sporulation	sporulation	NOUN
afs-72863	104	26	(	(	PUNCT
afs-72863	104	27	vesanto	vesanto	ADP
afs-72863	104	28	and	and	CCONJ
afs-72863	104	29	palva	palva	NOUN
afs-72863	104	30	,	,	PUNCT
afs-72863	104	31	unpublished	unpublished	ADJ
afs-72863	104	32	results	result	NOUN
afs-72863	104	33	)	)	PUNCT
afs-72863	104	34	.	.	PUNCT
afs-72863	105	1	we	we	PRON
afs-72863	105	2	isolated	isolate	VERB
afs-72863	105	3	l.	l.	PROPN
afs-72863	105	4	helveticus	helveticus	PROPN
afs-72863	105	5	53/7	53/7	NUM
afs-72863	105	6	dipeptidase	dipeptidase	ADJ
afs-72863	105	7	gene	gene	NOUN
afs-72863	105	8	(	(	PUNCT
afs-72863	105	9	pepd	pepd	NOUN
afs-72863	105	10	)	)	PUNCT
afs-72863	105	11	in	in	ADP
afs-72863	105	12	the	the	DET
afs-72863	105	13	same	same	ADJ
afs-72863	105	14	way	way	NOUN
afs-72863	105	15	as	as	ADP
afs-72863	105	16	pepn	pepn	NOUN
afs-72863	105	17	and	and	CCONJ
afs-72863	105	18	pepc	pepc	NOUN
afs-72863	105	19	(	(	PUNCT
afs-72863	105	20	vesanto	vesanto	ADP
afs-72863	105	21	et	et	PROPN
afs-72863	105	22	al	al	PROPN
afs-72863	105	23	.	.	PROPN
afs-72863	105	24	1996	1996	NUM
afs-72863	105	25	)	)	PUNCT
afs-72863	105	26	.	.	PUNCT
afs-72863	106	1	an	an	DET
afs-72863	106	2	open	open	ADJ
afs-72863	106	3	reading	reading	NOUN
afs-72863	106	4	frame	frame	NOUN
afs-72863	106	5	(	(	PUNCT
afs-72863	106	6	orf	orf	PROPN
afs-72863	106	7	)	)	PUNCT
afs-72863	106	8	of	of	ADP
afs-72863	106	9	1422	1422	NUM
afs-72863	106	10	bp	bp	PROPN
afs-72863	106	11	was	be	AUX
afs-72863	106	12	identified	identify	VERB
afs-72863	106	13	from	from	ADP
afs-72863	106	14	a	a	DET
afs-72863	106	15	positive	positive	ADJ
afs-72863	106	16	clone	clone	NOUN
afs-72863	106	17	with	with	ADP
afs-72863	106	18	a	a	DET
afs-72863	106	19	coding	code	VERB
afs-72863	106	20	capacity	capacity	NOUN
afs-72863	106	21	of	of	ADP
afs-72863	106	22	53.5	53.5	NUM
afs-72863	106	23	kda	kda	NOUN
afs-72863	106	24	.	.	PUNCT
afs-72863	107	1	the	the	DET
afs-72863	107	2	promoter	promoter	NOUN
afs-72863	107	3	and	and	CCONJ
afs-72863	107	4	transcription	transcription	NOUN
afs-72863	107	5	terminator	terminator	NOUN
afs-72863	107	6	regions	region	NOUN
afs-72863	107	7	were	be	AUX
afs-72863	107	8	also	also	ADV
afs-72863	107	9	identified	identify	VERB
afs-72863	107	10	.	.	PUNCT
afs-72863	108	1	the	the	DET
afs-72863	108	2	deduced	deduce	VERB
afs-72863	108	3	amino	amino	NOUN
afs-72863	108	4	acid	acid	NOUN
afs-72863	108	5	sequence	sequence	NOUN
afs-72863	108	6	of	of	ADP
afs-72863	108	7	the	the	DET
afs-72863	108	8	53.5	53.5	NUM
afs-72863	108	9	kda	kda	NOUN
afs-72863	108	10	protein	protein	NOUN
afs-72863	108	11	shared	share	VERB
afs-72863	108	12	no	no	DET
afs-72863	108	13	significant	significant	ADJ
afs-72863	108	14	similarity	similarity	NOUN
afs-72863	108	15	with	with	ADP
afs-72863	108	16	the	the	DET
afs-72863	108	17	sequences	sequence	NOUN
afs-72863	108	18	in	in	ADP
afs-72863	108	19	the	the	DET
afs-72863	108	20	data	data	NOUN
afs-72863	108	21	bases	basis	NOUN
afs-72863	108	22	but	but	CCONJ
afs-72863	108	23	showed	show	VERB
afs-72863	108	24	99.8	99.8	NUM
afs-72863	108	25	%	%	NOUN
afs-72863	108	26	overall	overall	ADJ
afs-72863	108	27	similarity	similarity	NOUN
afs-72863	108	28	to	to	PART
afs-72863	108	29	pepda	pepda	VERB
afs-72863	108	30	from	from	ADP
afs-72863	108	31	l.	l.	PROPN
afs-72863	108	32	helveticus	helveticus	PROPN
afs-72863	108	33	cnrz32	cnrz32	NOUN
afs-72863	108	34	(	(	PUNCT
afs-72863	108	35	dudley	dudley	PROPN
afs-72863	108	36	et	et	PROPN
afs-72863	108	37	al	al	PROPN
afs-72863	108	38	.	.	PROPN
afs-72863	108	39	1996	1996	NUM
afs-72863	108	40	)	)	PUNCT
afs-72863	108	41	.	.	PUNCT
afs-72863	109	1	for	for	ADP
afs-72863	109	2	s’end	s’end	VERB
afs-72863	109	3	mapping	map	VERB
afs-72863	109	4	ofprokaryotic	ofprokaryotic	ADJ
afs-72863	109	5	transcripts	transcript	NOUN
afs-72863	109	6	we	we	PRON
afs-72863	109	7	optimised	optimise	VERB
afs-72863	109	8	a	a	DET
afs-72863	109	9	method	method	NOUN
afs-72863	109	10	based	base	VERB
afs-72863	109	11	on	on	ADP
afs-72863	109	12	the	the	DET
afs-72863	109	13	use	use	NOUN
afs-72863	109	14	of	of	ADP
afs-72863	109	15	an	an	DET
afs-72863	109	16	automated	automate	VERB
afs-72863	109	17	dna	dna	NOUN
afs-72863	109	18	sequencer	sequencer	NOUN
afs-72863	109	19	(	(	PUNCT
afs-72863	109	20	vesanto	vesanto	ADP
afs-72863	109	21	et	et	PROPN
afs-72863	109	22	al	al	PROPN
afs-72863	109	23	.	.	PROPN
afs-72863	109	24	1996	1996	NUM
afs-72863	109	25	)	)	PUNCT
afs-72863	109	26	.	.	PUNCT
afs-72863	110	1	the	the	DET
afs-72863	110	2	5	5	NUM
afs-72863	110	3	’	'	PUNCT
afs-72863	110	4	end	end	NOUN
afs-72863	110	5	mapping	mapping	NOUN
afs-72863	110	6	of	of	ADP
afs-72863	110	7	the	the	DET
afs-72863	110	8	1.6	1.6	NUM
afs-72863	110	9	kb	kb	PROPN
afs-72863	110	10	pepd	pepd	NOUN
afs-72863	110	11	transcript	transcript	NOUN
afs-72863	110	12	by	by	ADP
afs-72863	110	13	the	the	DET
afs-72863	110	14	new	new	ADJ
afs-72863	110	15	and	and	CCONJ
afs-72863	110	16	conventional	conventional	ADJ
afs-72863	110	17	primer	primer	NOUN
afs-72863	110	18	extension	extension	NOUN
afs-72863	110	19	methods	method	NOUN
afs-72863	110	20	gave	give	VERB
afs-72863	110	21	consistent	consistent	ADJ
afs-72863	110	22	results	result	NOUN
afs-72863	110	23	.	.	PUNCT
afs-72863	111	1	expression	expression	NOUN
afs-72863	111	2	studies	study	NOUN
afs-72863	111	3	showed	show	VERB
afs-72863	111	4	thatpepd	thatpepd	PROPN
afs-72863	111	5	was	be	AUX
afs-72863	111	6	maximally	maximally	ADV
afs-72863	111	7	expressed	express	VERB
afs-72863	111	8	at	at	ADP
afs-72863	111	9	late	late	ADJ
afs-72863	111	10	exponential	exponential	ADJ
afs-72863	111	11	growth	growth	NOUN
afs-72863	111	12	.	.	PUNCT
afs-72863	112	1	we	we	PRON
afs-72863	112	2	also	also	ADV
afs-72863	112	3	overexpressed	overexpresse	VERB
afs-72863	112	4	the	the	DET
afs-72863	112	5	pepd	pepd	ADJ
afs-72863	112	6	gene	gene	NOUN
afs-72863	112	7	in	in	ADP
afs-72863	112	8	e.	e.	PROPN
afs-72863	112	9	coli	coli	PROPN
afs-72863	112	10	and	and	CCONJ
afs-72863	112	11	purified	purify	VERB
afs-72863	112	12	pepd	pepd	NOUN
afs-72863	112	13	to	to	ADP
afs-72863	112	14	homogeneity	homogeneity	NOUN
afs-72863	112	15	in	in	ADP
afs-72863	112	16	three	three	NUM
afs-72863	112	17	chromatographic	chromatographic	ADJ
afs-72863	112	18	steps	step	NOUN
afs-72863	112	19	.	.	PUNCT
afs-72863	113	1	studies	study	NOUN
afs-72863	113	2	of	of	ADP
afs-72863	113	3	the	the	DET
afs-72863	113	4	pepd	pepd	NOUN
afs-72863	113	5	substrate	substrate	NOUN
afs-72863	113	6	specificity	specificity	NOUN
afs-72863	113	7	showed	show	VERB
afs-72863	113	8	that	that	SCONJ
afs-72863	113	9	pepd	pepd	NOUN
afs-72863	113	10	was	be	AUX
afs-72863	113	11	able	able	ADJ
afs-72863	113	12	to	to	PART
afs-72863	113	13	hydrolyse	hydrolyse	VERB
afs-72863	113	14	a	a	DET
afs-72863	113	15	number	number	NOUN
afs-72863	113	16	of	of	ADP
afs-72863	113	17	dipeptides	dipeptide	NOUN
afs-72863	113	18	with	with	ADP
afs-72863	113	19	the	the	DET
afs-72863	113	20	exception	exception	NOUN
afs-72863	113	21	of	of	ADP
afs-72863	113	22	those	those	PRON
afs-72863	113	23	containing	contain	VERB
afs-72863	113	24	proline	proline	NOUN
afs-72863	113	25	residues	residue	NOUN
afs-72863	113	26	.	.	PUNCT
afs-72863	114	1	optimal	optimal	ADJ
afs-72863	114	2	pepd	pepd	ADJ
afs-72863	114	3	activity	activity	NOUN
afs-72863	114	4	was	be	AUX
afs-72863	114	5	obtained	obtain	VERB
afs-72863	114	6	at	at	ADP
afs-72863	114	7	ph	ph	PROPN
afs-72863	114	8	6.0	6.0	NUM
afs-72863	114	9	and	and	CCONJ
afs-72863	114	10	55	55	NUM
afs-72863	114	11	°	°	NOUN
afs-72863	114	12	c	c	NOUN
afs-72863	114	13	.	.	PUNCT
afs-72863	115	1	inhibition	inhibition	NOUN
afs-72863	115	2	studies	study	NOUN
afs-72863	115	3	of	of	ADP
afs-72863	115	4	pepd	pepd	NOUN
afs-72863	115	5	revealed	reveal	VERB
afs-72863	115	6	that	that	SCONJ
afs-72863	115	7	the	the	DET
afs-72863	115	8	enzyme	enzyme	NOUN
afs-72863	115	9	could	could	AUX
afs-72863	115	10	be	be	AUX
afs-72863	115	11	inhibitedby	inhibitedby	ADJ
afs-72863	115	12	phmb	phmb	NOUN
afs-72863	115	13	and	and	CCONJ
afs-72863	115	14	reactivated	reactivate	VERB
afs-72863	115	15	by	by	ADP
afs-72863	115	16	dithiothreitol	dithiothreitol	PROPN
afs-72863	115	17	;	;	PUNCT
afs-72863	115	18	edta	edta	NOUN
afs-72863	115	19	,	,	PUNCT
afs-72863	115	20	in	in	ADP
afs-72863	115	21	contrast	contrast	NOUN
afs-72863	115	22	had	have	VERB
afs-72863	115	23	no	no	DET
afs-72863	115	24	inhibitory	inhibitory	ADJ
afs-72863	115	25	effect	effect	NOUN
afs-72863	115	26	(	(	PUNCT
afs-72863	115	27	vesanto	vesanto	ADP
afs-72863	115	28	et	et	PROPN
afs-72863	115	29	al	al	PROPN
afs-72863	115	30	.	.	PROPN
afs-72863	115	31	1996	1996	NUM
afs-72863	115	32	)	)	PUNCT
afs-72863	115	33	.	.	PUNCT
afs-72863	116	1	in	in	ADP
afs-72863	116	2	addition	addition	NOUN
afs-72863	116	3	to	to	ADP
afs-72863	116	4	the	the	DET
afs-72863	116	5	lack	lack	NOUN
afs-72863	116	6	of	of	ADP
afs-72863	116	7	a	a	DET
afs-72863	116	8	homologous	homologous	ADJ
afs-72863	116	9	counterpart	counterpart	NOUN
afs-72863	116	10	among	among	ADP
afs-72863	116	11	lab	lab	NOUN
afs-72863	116	12	,	,	PUNCT
afs-72863	116	13	the	the	DET
afs-72863	116	14	enzymatic	enzymatic	ADJ
afs-72863	116	15	properties	property	NOUN
afs-72863	116	16	suggested	suggest	VERB
afs-72863	116	17	that	that	SCONJ
afs-72863	116	18	the	the	DET
afs-72863	116	19	two	two	NUM
afs-72863	116	20	pepds	pepds	NOUN
afs-72863	116	21	isolated	isolate	VERB
afs-72863	116	22	from	from	ADP
afs-72863	116	23	l.	l.	PROPN
afs-72863	116	24	helveticus	helveticus	PROPN
afs-72863	116	25	53/7	53/7	PROPN
afs-72863	116	26	and	and	CCONJ
afs-72863	116	27	cnrz32	cnrz32	NOUN
afs-72863	116	28	represented	represent	VERB
afs-72863	116	29	a	a	DET
afs-72863	116	30	novel	novel	ADJ
afs-72863	116	31	dipeptidase	dipeptidase	NOUN
afs-72863	116	32	type	type	NOUN
afs-72863	116	33	.	.	PUNCT
afs-72863	117	1	proline	proline	NOUN
afs-72863	117	2	specific	specific	ADJ
afs-72863	117	3	peptidases	peptidase	NOUN
afs-72863	117	4	of	of	ADP
afs-72863	117	5	l	l	NOUN
afs-72863	117	6	helveticus	helveticus	PROPN
afs-72863	117	7	53/7	53/7	NUM
afs-72863	117	8	milk	milk	NOUN
afs-72863	117	9	proteins	protein	NOUN
afs-72863	117	10	contain	contain	VERB
afs-72863	117	11	a	a	DET
afs-72863	117	12	large	large	ADJ
afs-72863	117	13	amount	amount	NOUN
afs-72863	117	14	of	of	ADP
afs-72863	117	15	proline	proline	NOUN
afs-72863	117	16	residues	residue	NOUN
afs-72863	117	17	,	,	PUNCT
afs-72863	117	18	which	which	PRON
afs-72863	117	19	,	,	PUNCT
afs-72863	117	20	in	in	ADP
afs-72863	117	21	free	free	ADJ
afs-72863	117	22	form	form	NOUN
afs-72863	117	23	impact	impact	NOUN
afs-72863	117	24	a	a	DET
afs-72863	117	25	sweet	sweet	ADJ
afs-72863	117	26	flavour	flavour	NOUN
afs-72863	117	27	to	to	ADP
afs-72863	117	28	cheese	cheese	NOUN
afs-72863	117	29	(	(	PUNCT
afs-72863	117	30	biede	biede	NOUN
afs-72863	117	31	and	and	CCONJ
afs-72863	117	32	hammond	hammond	NOUN
afs-72863	117	33	1979	1979	NUM
afs-72863	117	34	,	,	PUNCT
afs-72863	117	35	fox	fox	NOUN
afs-72863	117	36	1989	1989	NUM
afs-72863	117	37	)	)	PUNCT
afs-72863	117	38	.	.	PUNCT
afs-72863	118	1	proline	proline	NOUN
afs-72863	118	2	-	-	PUNCT
afs-72863	118	3	specific	specific	ADJ
afs-72863	118	4	peptidases	peptidase	NOUN
afs-72863	118	5	thereforeplay	thereforeplay	VERB
afs-72863	118	6	an	an	DET
afs-72863	118	7	important	important	ADJ
afs-72863	118	8	role	role	NOUN
afs-72863	118	9	in	in	ADP
afs-72863	118	10	cheese	cheese	NOUN
afs-72863	118	11	ripening	ripen	VERB
afs-72863	118	12	by	by	ADP
afs-72863	118	13	degrading	degrade	VERB
afs-72863	118	14	proline	proline	NOUN
afs-72863	118	15	-	-	PUNCT
afs-72863	118	16	containing	contain	VERB
afs-72863	118	17	peptides	peptide	NOUN
afs-72863	118	18	,	,	PUNCT
afs-72863	118	19	which	which	PRON
afs-72863	118	20	are	be	AUX
afs-72863	118	21	sometimes	sometimes	ADV
afs-72863	118	22	bitter	bitter	ADJ
afs-72863	118	23	,	,	PUNCT
afs-72863	118	24	and	and	CCONJ
afs-72863	118	25	by	by	ADP
afs-72863	118	26	making	make	VERB
afs-72863	118	27	peptides	peptide	NOUN
afs-72863	118	28	accessible	accessible	ADJ
afs-72863	118	29	to	to	ADP
afs-72863	118	30	further	further	ADJ
afs-72863	118	31	degradation	degradation	NOUN
afs-72863	118	32	by	by	ADP
afs-72863	118	33	other	other	ADJ
afs-72863	118	34	peptidases	peptidase	NOUN
afs-72863	118	35	through	through	ADP
afs-72863	118	36	the	the	DET
afs-72863	118	37	removal	removal	NOUN
afs-72863	118	38	of	of	ADP
afs-72863	118	39	proline	proline	NOUN
afs-72863	118	40	residues	residue	NOUN
afs-72863	118	41	(	(	PUNCT
afs-72863	118	42	baankreis	baankreis	ADV
afs-72863	118	43	and	and	CCONJ
afs-72863	118	44	exterkate	exterkate	ADJ
afs-72863	118	45	1991	1991	NUM
afs-72863	118	46	)	)	PUNCT
afs-72863	118	47	.	.	PUNCT
afs-72863	119	1	we	we	PRON
afs-72863	119	2	have	have	AUX
afs-72863	119	3	performed	perform	VERB
afs-72863	119	4	the	the	DET
afs-72863	119	5	molecular	molecular	ADJ
afs-72863	119	6	genetic	genetic	ADJ
afs-72863	119	7	and	and	CCONJ
afs-72863	119	8	biochemical	biochemical	ADJ
afs-72863	119	9	characterisation	characterisation	NOUN
afs-72863	119	10	of	of	ADP
afs-72863	119	11	three	three	NUM
afs-72863	119	12	different	different	ADJ
afs-72863	119	13	proline	proline	NOUN
afs-72863	119	14	specific	specific	ADJ
afs-72863	119	15	peptidases	peptidase	NOUN
afs-72863	119	16	,	,	PUNCT
afs-72863	119	17	i.e.	i.e.	X
afs-72863	119	18	x	x	X
afs-72863	119	19	-	-	ADJ
afs-72863	119	20	prolyl	prolyl	ADJ
afs-72863	119	21	dipeptidyl	dipeptidyl	NOUN
afs-72863	119	22	aminopeptidase	aminopeptidase	NOUN
afs-72863	119	23	(	(	PUNCT
afs-72863	119	24	pepx	pepx	NOUN
afs-72863	119	25	)	)	PUNCT
afs-72863	119	26	(	(	PUNCT
afs-72863	119	27	vesanto	vesanto	ADP
afs-72863	119	28	et	et	PROPN
afs-72863	119	29	al	al	PROPN
afs-72863	119	30	.	.	PROPN
afs-72863	119	31	1995	1995	NUM
afs-72863	119	32	)	)	PUNCT
afs-72863	119	33	,	,	PUNCT
afs-72863	119	34	prolinase	prolinase	NOUN
afs-72863	119	35	(	(	PUNCT
afs-72863	119	36	pepß	pepß	PROPN
afs-72863	119	37	)	)	PUNCT
afs-72863	119	38	(	(	PUNCT
afs-72863	119	39	varmanen	varmanen	VERB
afs-72863	119	40	et	et	PROPN
afs-72863	119	41	al	al	PROPN
afs-72863	119	42	.	.	PROPN
afs-72863	119	43	1996a	1996a	NUM
afs-72863	119	44	)	)	PUNCT
afs-72863	119	45	and	and	CCONJ
afs-72863	119	46	iminopeptidase	iminopeptidase	NOUN
afs-72863	119	47	(	(	PUNCT
afs-72863	119	48	pepi	pepi	PROPN
afs-72863	119	49	)	)	PUNCT
afs-72863	119	50	(	(	PUNCT
afs-72863	119	51	varmanen	varmanen	NOUN
afs-72863	119	52	et	et	PROPN
afs-72863	119	53	al	al	PROPN
afs-72863	119	54	.	.	PROPN
afs-72863	119	55	1996b	1996b	NUM
afs-72863	119	56	)	)	PUNCT
afs-72863	119	57	,	,	PUNCT
afs-72863	119	58	from	from	ADP
afs-72863	119	59	strain	strain	NOUN
afs-72863	119	60	53/7	53/7	NUM
afs-72863	119	61	.	.	PUNCT
afs-72863	120	1	the	the	DET
afs-72863	120	2	x	x	NOUN
afs-72863	120	3	-	-	ADJ
afs-72863	120	4	prolyl	prolyl	ADJ
afs-72863	120	5	dipeptidyl	dipeptidyl	NOUN
afs-72863	120	6	aminopeptidases	aminopeptidase	NOUN
afs-72863	120	7	cleave	cleave	VERB
afs-72863	120	8	dipeptidyl	dipeptidyl	NOUN
afs-72863	120	9	residues	residue	NOUN
afs-72863	120	10	from	from	ADP
afs-72863	120	11	peptides	peptide	NOUN
afs-72863	120	12	by	by	ADP
afs-72863	120	13	hydrolysing	hydrolyse	VERB
afs-72863	120	14	the	the	DET
afs-72863	120	15	peptide	peptide	NOUN
afs-72863	120	16	bond	bond	NOUN
afs-72863	120	17	at	at	ADP
afs-72863	120	18	the	the	DET
afs-72863	120	19	carboxyl	carboxyl	NOUN
afs-72863	120	20	side	side	NOUN
afs-72863	120	21	of	of	ADP
afs-72863	120	22	the	the	DET
afs-72863	120	23	proline	proline	NOUN
afs-72863	120	24	residue	residue	NOUN
afs-72863	120	25	when	when	SCONJ
afs-72863	120	26	this	this	DET
afs-72863	120	27	imino	imino	NOUN
afs-72863	120	28	acid	acid	NOUN
afs-72863	120	29	is	be	AUX
afs-72863	120	30	the	the	DET
afs-72863	120	31	penultimate	penultimate	NOUN
afs-72863	120	32	n	n	CCONJ
afs-72863	120	33	-	-	PUNCT
afs-72863	120	34	terminal	terminal	ADJ
afs-72863	120	35	residue	residue	NOUN
afs-72863	120	36	.	.	PUNCT
afs-72863	121	1	the	the	DET
afs-72863	121	2	pepx	pepx	ADJ
afs-72863	121	3	gene	gene	NOUN
afs-72863	121	4	cloned	clone	VERB
afs-72863	121	5	and	and	CCONJ
afs-72863	121	6	sequenced	sequence	VERB
afs-72863	121	7	from	from	ADP
afs-72863	121	8	strain	strain	NOUN
afs-72863	121	9	53/7	53/7	NUM
afs-72863	121	10	was	be	AUX
afs-72863	121	11	shown	show	VERB
afs-72863	121	12	to	to	PART
afs-72863	121	13	be	be	AUX
afs-72863	121	14	2379	2379	NUM
afs-72863	121	15	bp	bp	NOUN
afs-72863	121	16	in	in	ADP
afs-72863	121	17	size	size	NOUN
afs-72863	121	18	with	with	ADP
afs-72863	121	19	a	a	DET
afs-72863	121	20	coding	code	VERB
afs-72863	121	21	capacity	capacity	NOUN
afs-72863	121	22	for	for	ADP
afs-72863	121	23	a	a	DET
afs-72863	121	24	90.6	90.6	NUM
afs-72863	121	25	kda	kda	NOUN
afs-72863	121	26	protein	protein	NOUN
afs-72863	121	27	(	(	PUNCT
afs-72863	121	28	vesanto	vesanto	ADP
afs-72863	121	29	et	et	PROPN
afs-72863	121	30	al	al	PROPN
afs-72863	121	31	.	.	PROPN
afs-72863	121	32	1995	1995	NUM
afs-72863	121	33	)	)	PUNCT
afs-72863	121	34	.	.	PUNCT
afs-72863	122	1	the	the	DET
afs-72863	122	2	pepx	pepx	ADJ
afs-72863	122	3	gene	gene	NOUN
afs-72863	122	4	was	be	AUX
afs-72863	122	5	identified	identify	VERB
afs-72863	122	6	as	as	ADP
afs-72863	122	7	a	a	DET
afs-72863	122	8	monocistronic	monocistronic	ADJ
afs-72863	122	9	transcription	transcription	NOUN
afs-72863	122	10	unit	unit	NOUN
afs-72863	122	11	flanked	flank	VERB
afs-72863	122	12	by	by	ADP
afs-72863	122	13	a	a	DET
afs-72863	122	14	typical	typical	ADJ
afs-72863	122	15	prokaryotic	prokaryotic	ADJ
afs-72863	122	16	promoter	promoter	NOUN
afs-72863	122	17	region	region	NOUN
afs-72863	122	18	and	and	CCONJ
afs-72863	122	19	transcription	transcription	NOUN
afs-72863	122	20	terminator(delta	terminator(delta	PROPN
afs-72863	122	21	g-84.1	g-84.1	NOUN
afs-72863	122	22	kj	kj	PROPN
afs-72863	122	23	mol	mol	PROPN
afs-72863	122	24	'	'	PART
afs-72863	122	25	1	1	NUM
afs-72863	122	26	)	)	PUNCT
afs-72863	122	27	.	.	PUNCT
afs-72863	123	1	the	the	DET
afs-72863	123	2	deduced	deduce	VERB
afs-72863	123	3	amino	amino	NOUN
afs-72863	123	4	acid	acid	NOUN
afs-72863	123	5	sequence	sequence	NOUN
afs-72863	123	6	of	of	ADP
afs-72863	123	7	the	the	DET
afs-72863	123	8	90.6	90.6	NUM
afs-72863	123	9	kda	kda	NOUN
afs-72863	123	10	protein	protein	NOUN
afs-72863	123	11	shared	share	VERB
afs-72863	123	12	49.3	49.3	NUM
afs-72863	123	13	,	,	PUNCT
afs-72863	123	14	49.4	49.4	NUM
afs-72863	123	15	and	and	CCONJ
afs-72863	123	16	77.7	77.7	NUM
afs-72863	123	17	%	%	NOUN
afs-72863	123	18	overall	overall	ADJ
afs-72863	123	19	similarity	similarity	NOUN
afs-72863	123	20	with	with	ADP
afs-72863	123	21	the	the	DET
afs-72863	123	22	pepx	pepx	ADJ
afs-72863	123	23	proteins	protein	NOUN
afs-72863	123	24	from	from	ADP
afs-72863	123	25	lactococcus	lactococcus	PROPN
afs-72863	123	26	lactis	lactis	PROPN
afs-72863	123	27	subsp	subsp	PROPN
afs-72863	123	28	.	.	PUNCT
afs-72863	124	1	lactis	lactis	PROPN
afs-72863	124	2	(	(	PUNCT
afs-72863	124	3	mayo	mayo	NOUN
afs-72863	124	4	et	et	PROPN
afs-72863	124	5	al	al	PROPN
afs-72863	124	6	.	.	PROPN
afs-72863	124	7	1991	1991	NUM
afs-72863	124	8	)	)	PUNCT
afs-72863	124	9	,	,	PUNCT
afs-72863	124	10	lactococcus	lactococcus	PROPN
afs-72863	124	11	lactis	lactis	PROPN
afs-72863	124	12	subsp	subsp	PROPN
afs-72863	124	13	.	.	PUNCT
afs-72863	125	1	cremoris	cremoris	PROPN
afs-72863	125	2	(	(	PUNCT
afs-72863	125	3	nardi	nardi	PROPN
afs-72863	125	4	et	et	PROPN
afs-72863	125	5	al	al	PROPN
afs-72863	125	6	.	.	PROPN
afs-72863	125	7	1991	1991	NUM
afs-72863	125	8	)	)	PUNCT
afs-72863	125	9	and	and	CCONJ
afs-72863	125	10	l.	l.	PROPN
afs-72863	125	11	delbrueckii	delbrueckii	PROPN
afs-72863	125	12	subsp	subsp	PROPN
afs-72863	125	13	.	.	PUNCT
afs-72863	126	1	lactis	lactis	PROPN
afs-72863	126	2	(	(	PUNCT
afs-72863	126	3	meyer	meyer	PROPN
afs-72863	126	4	-	-	PUNCT
afs-72863	126	5	barton	barton	PROPN
afs-72863	126	6	et	et	PROPN
afs-72863	126	7	al	al	PROPN
afs-72863	126	8	.	.	PROPN
afs-72863	126	9	1993	1993	NUM
afs-72863	126	10	)	)	PUNCT
afs-72863	126	11	,	,	PUNCT
afs-72863	126	12	respectively	respectively	ADV
afs-72863	126	13	.	.	PUNCT
afs-72863	127	1	the	the	DET
afs-72863	127	2	size	size	NOUN
afs-72863	127	3	(	(	PUNCT
afs-72863	127	4	2.6	2.6	NUM
afs-72863	127	5	kb	kb	NOUN
afs-72863	127	6	)	)	PUNCT
afs-72863	127	7	and	and	CCONJ
afs-72863	127	8	s’end	s’end	VERB
afs-72863	127	9	ofpepx	ofpepx	PROPN
afs-72863	127	10	mrna	mrna	PROPN
afs-72863	127	11	were	be	AUX
afs-72863	127	12	in	in	ADP
afs-72863	127	13	agreement	agreement	NOUN
afs-72863	127	14	with	with	ADP
afs-72863	127	15	the	the	DET
afs-72863	127	16	dna	dna	PROPN
afs-72863	127	17	sequence	sequence	NOUN
afs-72863	127	18	data	datum	NOUN
afs-72863	127	19	.	.	PUNCT
afs-72863	128	1	similarly	similarly	ADV
afs-72863	128	2	to	to	ADP
afs-72863	128	3	the	the	DET
afs-72863	128	4	other	other	ADJ
afs-72863	128	5	l.	l.	PROPN
afs-72863	128	6	helveticus	helveticus	PROPN
afs-72863	128	7	peptidases	peptidase	NOUN
afs-72863	128	8	analysed	analyse	VERB
afs-72863	128	9	,	,	PUNCT
afs-72863	128	10	expression	expression	NOUN
afs-72863	128	11	ofpepx	ofpepx	NOUN
afs-72863	128	12	was	be	AUX
afs-72863	128	13	typical	typical	ADJ
afs-72863	128	14	of	of	ADP
afs-72863	128	15	exponential	exponential	ADJ
afs-72863	128	16	growth	growth	NOUN
afs-72863	128	17	.	.	PUNCT
afs-72863	129	1	the	the	DET
afs-72863	129	2	pepx	pepx	ADJ
afs-72863	129	3	gene	gene	NOUN
afs-72863	129	4	was	be	AUX
afs-72863	129	5	also	also	ADV
afs-72863	129	6	overexpressed	overexpresse	VERB
afs-72863	129	7	in	in	ADP
afs-72863	129	8	pkk223	pkk223	PROPN
afs-72863	129	9	-	-	PUNCT
afs-72863	129	10	3	3	NUM
afs-72863	129	11	in	in	ADP
afs-72863	129	12	e.	e.	PROPN
afs-72863	129	13	coli	coli	PROPN
afs-72863	129	14	followed	follow	VERB
afs-72863	129	15	by	by	ADP
afs-72863	129	16	purification	purification	NOUN
afs-72863	129	17	of	of	ADP
afs-72863	129	18	pepx	pepx	NOUN
afs-72863	129	19	to	to	ADP
afs-72863	129	20	homogeneity	homogeneity	NOUN
afs-72863	129	21	by	by	ADP
afs-72863	129	22	ion	ion	NOUN
afs-72863	129	23	-	-	PUNCT
afs-72863	129	24	exchange	exchange	NOUN
afs-72863	129	25	and	and	CCONJ
afs-72863	129	26	hydrophobic	hydrophobic	NOUN
afs-72863	129	27	interaction	interaction	NOUN
afs-72863	129	28	272	272	NUM
afs-72863	129	29	seminar	seminar	NOUN
afs-72863	129	30	in	in	ADP
afs-72863	129	31	honour	honour	NOUN
afs-72863	129	32	of	of	ADP
afs-72863	129	33	the	the	DET
afs-72863	129	34	1ooth	1ooth	NUM
afs-72863	129	35	anniversary	anniversary	NOUN
afs-72863	129	36	ofmtt	ofmtt	NOUN
afs-72863	129	37	agricultural	agricultural	ADJ
afs-72863	129	38	and	and	CCONJ
afs-72863	129	39	food	food	NOUN
afs-72863	129	40	science	science	NOUN
afs-72863	129	41	in	in	ADP
afs-72863	129	42	finland	finland	PROPN
afs-72863	129	43	chromatography	chromatography	NOUN
afs-72863	129	44	.	.	PUNCT
afs-72863	130	1	the	the	DET
afs-72863	130	2	enzyme	enzyme	NOUN
afs-72863	130	3	was	be	AUX
afs-72863	130	4	found	find	VERB
afs-72863	130	5	to	to	PART
afs-72863	130	6	be	be	AUX
afs-72863	130	7	a	a	DET
afs-72863	130	8	dimer	dimer	NOUN
afs-72863	130	9	(	(	PUNCT
afs-72863	130	10	165	165	NUM
afs-72863	130	11	kda	kda	NOUN
afs-72863	130	12	)	)	PUNCT
afs-72863	130	13	with	with	ADP
afs-72863	130	14	optimum	optimum	ADJ
afs-72863	130	15	activity	activity	NOUN
afs-72863	130	16	at	at	ADP
afs-72863	130	17	ph	ph	PROPN
afs-72863	130	18	6.5	6.5	NUM
afs-72863	130	19	and	and	CCONJ
afs-72863	130	20	45	45	NUM
afs-72863	130	21	°	°	NOUN
afs-72863	130	22	c	c	NOUN
afs-72863	130	23	.	.	PUNCT
afs-72863	131	1	furthermore	furthermore	ADV
afs-72863	131	2	,	,	PUNCT
afs-72863	131	3	pepx	pepx	NOUN
afs-72863	131	4	was	be	AUX
afs-72863	131	5	shown	show	VERB
afs-72863	131	6	to	to	PART
afs-72863	131	7	be	be	AUX
afs-72863	131	8	a	a	DET
afs-72863	131	9	metal	metal	NOUN
afs-72863	131	10	-	-	PUNCT
afs-72863	131	11	independent	independent	NOUN
afs-72863	131	12	serinepeptidase	serinepeptidase	NOUN
afs-72863	131	13	,	,	PUNCT
afs-72863	131	14	having	have	VERB
afs-72863	131	15	functional	functional	ADJ
afs-72863	131	16	sulphhydryl	sulphhydryl	NOUN
afs-72863	131	17	groups	group	NOUN
afs-72863	131	18	at	at	ADP
afs-72863	131	19	or	or	CCONJ
afs-72863	131	20	near	near	ADP
afs-72863	131	21	the	the	DET
afs-72863	131	22	active	active	ADJ
afs-72863	131	23	site	site	NOUN
afs-72863	131	24	(	(	PUNCT
afs-72863	131	25	vesanto	vesanto	ADP
afs-72863	131	26	et	et	PROPN
afs-72863	131	27	al	al	PROPN
afs-72863	131	28	.	.	PROPN
afs-72863	131	29	1995	1995	NUM
afs-72863	131	30	)	)	PUNCT
afs-72863	131	31	.	.	PUNCT
afs-72863	132	1	thus	thus	ADV
afs-72863	132	2	,	,	PUNCT
afs-72863	132	3	the	the	DET
afs-72863	132	4	characteristics	characteristic	NOUN
afs-72863	132	5	of	of	ADP
afs-72863	132	6	the	the	DET
afs-72863	132	7	l.	l.	PROPN
afs-72863	132	8	helveticus	helveticus	PROPN
afs-72863	132	9	pepx	pepx	NOUN
afs-72863	132	10	closely	closely	ADV
afs-72863	132	11	resembled	resemble	VERB
afs-72863	132	12	those	those	PRON
afs-72863	132	13	of	of	ADP
afs-72863	132	14	other	other	ADJ
afs-72863	132	15	pepxs	pepxs	NOUN
afs-72863	132	16	.	.	PUNCT
afs-72863	133	1	prolinases	prolinase	NOUN
afs-72863	133	2	cleave	cleave	VERB
afs-72863	133	3	dipeptides	dipeptide	NOUN
afs-72863	133	4	with	with	ADP
afs-72863	133	5	a	a	DET
afs-72863	133	6	proline	proline	NOUN
afs-72863	133	7	residue	residue	NOUN
afs-72863	133	8	at	at	ADP
afs-72863	133	9	the	the	DET
afs-72863	133	10	n	n	CCONJ
afs-72863	133	11	-	-	PUNCT
afs-72863	133	12	terminal	terminal	ADJ
afs-72863	133	13	amino	amino	NOUN
afs-72863	133	14	acid	acid	NOUN
afs-72863	133	15	.	.	PUNCT
afs-72863	134	1	we	we	PRON
afs-72863	134	2	cloned	clone	VERB
afs-72863	134	3	a	a	DET
afs-72863	134	4	prolinase	prolinase	NOUN
afs-72863	134	5	(	(	PUNCT
afs-72863	134	6	pepß	pepß	PROPN
afs-72863	134	7	)	)	PUNCT
afs-72863	134	8	from	from	ADP
afs-72863	134	9	strain	strain	NOUN
afs-72863	134	10	53/7	53/7	NUM
afs-72863	134	11	with	with	ADP
afs-72863	134	12	a	a	DET
afs-72863	134	13	gene	gene	NOUN
afs-72863	134	14	probe	probe	NOUN
afs-72863	134	15	(	(	PUNCT
afs-72863	134	16	nowakowski	nowakowski	PROPN
afs-72863	134	17	et	et	PROPN
afs-72863	134	18	al	al	PROPN
afs-72863	134	19	.	.	PROPN
afs-72863	134	20	1993	1993	NUM
afs-72863	134	21	)	)	PUNCT
afs-72863	134	22	specific	specific	ADJ
afs-72863	134	23	for	for	ADP
afs-72863	134	24	a	a	DET
afs-72863	134	25	peptidase	peptidase	NOUN
afs-72863	134	26	shown	show	VERB
afs-72863	134	27	to	to	PART
afs-72863	134	28	have	have	VERB
afs-72863	134	29	activity	activity	NOUN
afs-72863	134	30	against	against	ADP
afs-72863	134	31	diand	diand	NOUN
afs-72863	134	32	tripeptides	tripeptide	NOUN
afs-72863	134	33	(	(	PUNCT
afs-72863	134	34	varmanen	varmanen	VERB
afs-72863	134	35	et	et	PROPN
afs-72863	134	36	al	al	PROPN
afs-72863	134	37	.	.	PROPN
afs-72863	134	38	1996a	1996a	NUM
afs-72863	134	39	)	)	PUNCT
afs-72863	134	40	.	.	PUNCT
afs-72863	135	1	the	the	DET
afs-72863	135	2	hybridisation	hybridisation	NOUN
afs-72863	135	3	positive	positive	ADJ
afs-72863	135	4	clones	clone	NOUN
afs-72863	135	5	obtained	obtain	VERB
afs-72863	135	6	,	,	PUNCT
afs-72863	135	7	however	however	ADV
afs-72863	135	8	,	,	PUNCT
afs-72863	135	9	did	do	AUX
afs-72863	135	10	not	not	PART
afs-72863	135	11	show	show	VERB
afs-72863	135	12	any	any	DET
afs-72863	135	13	enzyme	enzyme	NOUN
afs-72863	135	14	activity	activity	NOUN
afs-72863	135	15	against	against	ADP
afs-72863	135	16	dior	dior	PROPN
afs-72863	135	17	tripeptides	tripeptide	NOUN
afs-72863	135	18	.	.	PUNCT
afs-72863	136	1	further	further	ADJ
afs-72863	136	2	analysis	analysis	NOUN
afs-72863	136	3	of	of	ADP
afs-72863	136	4	one	one	NUM
afs-72863	136	5	of	of	ADP
afs-72863	136	6	the	the	DET
afs-72863	136	7	clones	clone	NOUN
afs-72863	136	8	with	with	ADP
afs-72863	136	9	a	a	DET
afs-72863	136	10	5.5	5.5	NUM
afs-72863	136	11	kb	kb	PROPN
afs-72863	136	12	insert	insert	NOUN
afs-72863	136	13	revealed	reveal	VERB
afs-72863	136	14	two	two	NUM
afs-72863	136	15	orfs	orf	NOUN
afs-72863	136	16	,	,	PUNCT
afs-72863	136	17	of	of	ADP
afs-72863	136	18	912	912	NUM
afs-72863	136	19	and	and	CCONJ
afs-72863	136	20	1602	1602	NUM
afs-72863	136	21	bp	bp	PROPN
afs-72863	136	22	,	,	PUNCT
afs-72863	136	23	orf2	orf2	ADJ
afs-72863	136	24	,	,	PUNCT
afs-72863	136	25	located	locate	VERB
afs-72863	136	26	upstream	upstream	NOUN
afs-72863	136	27	of	of	ADP
afs-72863	136	28	and	and	CCONJ
afs-72863	136	29	opposite	opposite	ADJ
afs-72863	136	30	in	in	ADP
afs-72863	136	31	orientation	orientation	NOUN
afs-72863	136	32	to	to	PART
afs-72863	136	33	orfi	orfi	PROPN
afs-72863	136	34	,	,	PUNCT
afs-72863	136	35	had	have	VERB
afs-72863	136	36	a	a	DET
afs-72863	136	37	promoter	promoter	NOUN
afs-72863	136	38	region	region	NOUN
afs-72863	136	39	overlapping	overlap	VERB
afs-72863	136	40	that	that	PRON
afs-72863	136	41	of	of	ADP
afs-72863	136	42	orfi	orfi	NOUN
afs-72863	136	43	.	.	PUNCT
afs-72863	137	1	orfi	orfi	PROPN
afs-72863	137	2	had	have	VERB
afs-72863	137	3	a	a	DET
afs-72863	137	4	codine	codine	NOUN
afs-72863	137	5	capacity	capacity	NOUN
afs-72863	137	6	for	for	ADP
afs-72863	137	7	a	a	DET
afs-72863	137	8	35	35	NUM
afs-72863	137	9	kda	kda	NOUN
afs-72863	137	10	protein	protein	NOUN
afs-72863	137	11	.	.	PUNCT
afs-72863	138	1	this	this	DET
afs-72863	138	2	protein	protein	NOUN
afs-72863	138	3	was	be	AUX
afs-72863	138	4	shown	show	VERB
afs-72863	138	5	to	to	PART
afs-72863	138	6	be	be	AUX
afs-72863	138	7	capable	capable	ADJ
afs-72863	138	8	of	of	ADP
afs-72863	138	9	hydrolysing	hydrolyse	VERB
afs-72863	138	10	dipeptides	dipeptide	NOUN
afs-72863	138	11	when	when	SCONJ
afs-72863	138	12	orfi	orfi	PROPN
afs-72863	138	13	was	be	AUX
afs-72863	138	14	amplified	amplify	VERB
afs-72863	138	15	by	by	ADP
afs-72863	138	16	pcr	pcr	PROPN
afs-72863	138	17	with	with	ADP
afs-72863	138	18	its	its	PRON
afs-72863	138	19	control	control	NOUN
afs-72863	138	20	regions	region	NOUN
afs-72863	138	21	and	and	CCONJ
afs-72863	138	22	expressed	express	VERB
afs-72863	138	23	in	in	ADP
afs-72863	138	24	e.	e.	PROPN
afs-72863	138	25	coli	coli	PROPN
afs-72863	138	26	.	.	PUNCT
afs-72863	139	1	among	among	ADP
afs-72863	139	2	the	the	DET
afs-72863	139	3	dipeptides	dipeptide	NOUN
afs-72863	139	4	tested	test	VERB
afs-72863	139	5	,	,	PUNCT
afs-72863	139	6	the	the	DET
afs-72863	139	7	highest	high	ADJ
afs-72863	139	8	activity	activity	NOUN
afs-72863	139	9	was	be	AUX
afs-72863	139	10	obtained	obtain	VERB
afs-72863	139	11	with	with	ADP
afs-72863	139	12	a	a	DET
afs-72863	139	13	pro	pro	ADJ
afs-72863	139	14	-	-	ADJ
afs-72863	139	15	leu	leu	ADJ
afs-72863	139	16	substrate	substrate	NOUN
afs-72863	139	17	whereas	whereas	SCONJ
afs-72863	139	18	among	among	ADP
afs-72863	139	19	the	the	DET
afs-72863	139	20	tripeptides	tripeptide	NOUN
afs-72863	139	21	tested	test	VERB
afs-72863	139	22	,	,	PUNCT
afs-72863	139	23	only	only	ADV
afs-72863	139	24	leu	leu	PROPN
afs-72863	139	25	-	-	PUNCT
afs-72863	139	26	leuleu	leuleu	NOUN
afs-72863	139	27	was	be	AUX
afs-72863	139	28	marginally	marginally	ADV
afs-72863	139	29	degraded	degrade	VERB
afs-72863	139	30	.	.	PUNCT
afs-72863	140	1	thus	thus	ADV
afs-72863	140	2	,	,	PUNCT
afs-72863	140	3	the	the	DET
afs-72863	140	4	35	35	NUM
afs-72863	140	5	kda	kda	NOUN
afs-72863	140	6	protein	protein	NOUN
afs-72863	140	7	was	be	AUX
afs-72863	140	8	identified	identify	VERB
afs-72863	140	9	as	as	ADP
afs-72863	140	10	a	a	DET
afs-72863	140	11	prolinase	prolinase	NOUN
afs-72863	140	12	(	(	PUNCT
afs-72863	140	13	pepß	pepß	PROPN
afs-72863	140	14	)	)	PUNCT
afs-72863	140	15	from	from	ADP
afs-72863	140	16	the	the	DET
afs-72863	140	17	substrate	substrate	NOUN
afs-72863	140	18	-	-	PUNCT
afs-72863	140	19	specificity	specificity	NOUN
afs-72863	140	20	profile	profile	NOUN
afs-72863	140	21	and	and	CCONJ
afs-72863	140	22	protein	protein	NOUN
afs-72863	140	23	homologies	homology	NOUN
afs-72863	140	24	(	(	PUNCT
afs-72863	140	25	varmanen	varmanen	NOUN
afs-72863	140	26	et	et	PROPN
afs-72863	140	27	al	al	PROPN
afs-72863	140	28	.	.	PROPN
afs-72863	140	29	1996a	1996a	NUM
afs-72863	140	30	)	)	PUNCT
afs-72863	140	31	.	.	PUNCT
afs-72863	141	1	the	the	DET
afs-72863	141	2	activity	activity	NOUN
afs-72863	141	3	of	of	ADP
afs-72863	141	4	the	the	DET
afs-72863	141	5	cloned	clone	VERB
afs-72863	141	6	pepß	pepß	PROPN
afs-72863	141	7	was	be	AUX
afs-72863	141	8	inhibited	inhibit	VERB
afs-72863	141	9	by	by	ADP
afs-72863	141	10	phmb	phmb	NOUN
afs-72863	141	11	.	.	PUNCT
afs-72863	142	1	in	in	ADP
afs-72863	142	2	accordance	accordance	NOUN
afs-72863	142	3	with	with	ADP
afs-72863	142	4	the	the	DET
afs-72863	142	5	dna	dna	PROPN
afs-72863	142	6	sequence	sequence	NOUN
afs-72863	142	7	data	datum	NOUN
afs-72863	142	8	,	,	PUNCT
afs-72863	142	9	northern	northern	ADJ
afs-72863	142	10	and	and	CCONJ
afs-72863	142	11	primer	primer	NOUN
afs-72863	142	12	-	-	PUNCT
afs-72863	142	13	extension	extension	NOUN
afs-72863	142	14	analyses	analysis	NOUN
afs-72863	142	15	of	of	ADP
afs-72863	142	16	pepß	pepß	PROPN
afs-72863	142	17	showed	show	VERB
afs-72863	142	18	a	a	DET
afs-72863	142	19	1.25	1.25	NUM
afs-72863	142	20	kb	kb	PROPN
afs-72863	142	21	transcript	transcript	NOUN
afs-72863	142	22	and	and	CCONJ
afs-72863	142	23	two	two	NUM
afs-72863	142	24	adjacent	adjacent	ADJ
afs-72863	142	25	transcription	transcription	NOUN
afs-72863	142	26	start	start	VERB
afs-72863	142	27	sites	site	NOUN
afs-72863	142	28	,	,	PUNCT
afs-72863	142	29	respectively	respectively	ADV
afs-72863	142	30	.	.	PUNCT
afs-72863	143	1	pepß	pepß	PROPN
afs-72863	143	2	protein	protein	NOUN
afs-72863	143	3	was	be	AUX
afs-72863	143	4	found	find	VERB
afs-72863	143	5	to	to	PART
afs-72863	143	6	be	be	AUX
afs-72863	143	7	99.6	99.6	NUM
afs-72863	143	8	%	%	NOUN
afs-72863	143	9	identical	identical	ADJ
afs-72863	143	10	to	to	ADP
afs-72863	143	11	the	the	DET
afs-72863	143	12	recently	recently	ADV
afs-72863	143	13	sequenced	sequence	VERB
afs-72863	143	14	prolinase	prolinase	NOUN
afs-72863	143	15	(	(	PUNCT
afs-72863	143	16	peppn	peppn	NOUN
afs-72863	143	17	)	)	PUNCT
afs-72863	143	18	from	from	ADP
afs-72863	143	19	l.	l.	PROPN
afs-72863	143	20	helveticus	helveticus	PROPN
afs-72863	143	21	cnrz32	cnrz32	NOUN
afs-72863	143	22	(	(	PUNCT
afs-72863	143	23	dudley	dudley	PROPN
afs-72863	143	24	and	and	CCONJ
afs-72863	143	25	steele	steele	PROPN
afs-72863	143	26	1994	1994	NUM
afs-72863	143	27	)	)	PUNCT
afs-72863	143	28	,	,	PUNCT
afs-72863	143	29	thus	thus	ADV
afs-72863	143	30	further	far	ADV
afs-72863	143	31	confirming	confirm	VERB
afs-72863	143	32	the	the	DET
afs-72863	143	33	close	close	ADJ
afs-72863	143	34	similarity	similarity	NOUN
afs-72863	143	35	of	of	ADP
afs-72863	143	36	the	the	DET
afs-72863	143	37	peptidases	peptidase	NOUN
afs-72863	143	38	of	of	ADP
afs-72863	143	39	these	these	DET
afs-72863	143	40	two	two	NUM
afs-72863	143	41	l.	l.	PROPN
afs-72863	143	42	helveticus	helveticus	PROPN
afs-72863	143	43	strains	strain	NOUN
afs-72863	143	44	,	,	PUNCT
afs-72863	143	45	which	which	PRON
afs-72863	143	46	otherwise	otherwise	ADV
afs-72863	143	47	differ	differ	VERB
afs-72863	143	48	from	from	ADP
afs-72863	143	49	each	each	DET
afs-72863	143	50	other	other	ADJ
afs-72863	143	51	.	.	PUNCT
afs-72863	144	1	interestingly	interestingly	ADV
afs-72863	144	2	,	,	PUNCT
afs-72863	144	3	analysis	analysis	NOUN
afs-72863	144	4	of	of	ADP
afs-72863	144	5	the	the	DET
afs-72863	144	6	upstream	upstream	ADJ
afs-72863	144	7	orf2	orf2	NOUN
afs-72863	144	8	revealed	reveal	VERB
afs-72863	144	9	that	that	SCONJ
afs-72863	144	10	the	the	DET
afs-72863	144	11	deduced	deduce	VERB
afs-72863	144	12	59.5	59.5	NUM
afs-72863	144	13	kda	kda	NOUN
afs-72863	144	14	protein	protein	NOUN
afs-72863	144	15	encoded	encode	VERB
afs-72863	144	16	by	by	ADP
afs-72863	144	17	this	this	DET
afs-72863	144	18	gene	gene	NOUN
afs-72863	144	19	showed	show	VERB
afs-72863	144	20	significant	significant	ADJ
afs-72863	144	21	homology	homology	NOUN
afs-72863	144	22	to	to	ADP
afs-72863	144	23	several	several	ADJ
afs-72863	144	24	members	member	NOUN
afs-72863	144	25	of	of	ADP
afs-72863	144	26	the	the	DET
afs-72863	144	27	family	family	NOUN
afs-72863	144	28	of	of	ADP
afs-72863	144	29	abc	abc	PROPN
afs-72863	144	30	transporters	transporters	PROPN
afs-72863	144	31	.	.	PUNCT
afs-72863	145	1	deletion	deletion	NOUN
afs-72863	145	2	constructs	construct	NOUN
afs-72863	145	3	of	of	ADP
afs-72863	145	4	orf2	orf2	NOUN
afs-72863	145	5	also	also	ADV
afs-72863	145	6	clearly	clearly	ADV
afs-72863	145	7	demonstrated	demonstrate	VERB
afs-72863	145	8	that	that	SCONJ
afs-72863	145	9	this	this	DET
afs-72863	145	10	upstream	upstream	ADJ
afs-72863	145	11	operon	operon	NOUN
afs-72863	145	12	adversely	adversely	ADV
afs-72863	145	13	affected	affect	VERB
afs-72863	145	14	pepß	pepß	ADJ
afs-72863	145	15	activity	activity	NOUN
afs-72863	145	16	in	in	ADP
afs-72863	145	17	e.	e.	PROPN
afs-72863	145	18	coli	coli	PROPN
afs-72863	145	19	,	,	PUNCT
afs-72863	145	20	explaining	explain	VERB
afs-72863	145	21	the	the	DET
afs-72863	145	22	enzymatic	enzymatic	ADJ
afs-72863	145	23	inactivity	inactivity	NOUN
afs-72863	145	24	of	of	ADP
afs-72863	145	25	the	the	DET
afs-72863	145	26	original	original	ADJ
afs-72863	145	27	clones	clone	NOUN
afs-72863	145	28	(	(	PUNCT
afs-72863	145	29	varmanen	varmanen	VERB
afs-72863	145	30	et	et	PROPN
afs-72863	145	31	al	al	PROPN
afs-72863	145	32	.	.	PROPN
afs-72863	145	33	1996a	1996a	NUM
afs-72863	145	34	)	)	PUNCT
afs-72863	145	35	.	.	PUNCT
afs-72863	146	1	proline	proline	NOUN
afs-72863	146	2	iminopeptidases	iminopeptidase	NOUN
afs-72863	146	3	(	(	PUNCT
afs-72863	146	4	pepl	pepl	NOUN
afs-72863	146	5	)	)	PUNCT
afs-72863	146	6	are	be	AUX
afs-72863	146	7	able	able	ADJ
afs-72863	146	8	to	to	PART
afs-72863	146	9	liberate	liberate	VERB
afs-72863	146	10	the	the	DET
afs-72863	146	11	n	n	CCONJ
afs-72863	146	12	-	-	PUNCT
afs-72863	146	13	terminal	terminal	ADJ
afs-72863	146	14	proline	proline	NOUN
afs-72863	146	15	residue	residue	NOUN
afs-72863	146	16	from	from	ADP
afs-72863	146	17	diand	diand	NOUN
afs-72863	146	18	tripeptides	tripeptide	NOUN
afs-72863	146	19	.	.	PUNCT
afs-72863	147	1	the	the	DET
afs-72863	147	2	l.	l.	PROPN
afs-72863	147	3	helveticus	helveticus	PROPN
afs-72863	147	4	53/7	53/7	NUM
afs-72863	147	5	proline	proline	NOUN
afs-72863	147	6	iminopeptidase	iminopeptidase	NOUN
afs-72863	147	7	gene	gene	NOUN
afs-72863	147	8	(	(	PUNCT
afs-72863	147	9	pepl	pepl	PROPN
afs-72863	147	10	)	)	PUNCT
afs-72863	147	11	cloned	clone	VERB
afs-72863	147	12	by	by	ADP
afs-72863	147	13	us	we	PRON
afs-72863	147	14	(	(	PUNCT
afs-72863	147	15	varmanen	varmanen	NOUN
afs-72863	147	16	et	et	PROPN
afs-72863	147	17	al	al	PROPN
afs-72863	147	18	.	.	PROPN
afs-72863	147	19	1996b	1996b	NUM
afs-72863	147	20	)	)	PUNCT
afs-72863	147	21	,	,	PUNCT
afs-72863	147	22	was	be	AUX
afs-72863	147	23	found	find	VERB
afs-72863	147	24	to	to	PART
afs-72863	147	25	be	be	AUX
afs-72863	147	26	organised	organise	VERB
afs-72863	147	27	in	in	ADP
afs-72863	147	28	an	an	DET
afs-72863	147	29	operon	operon	NOUN
afs-72863	147	30	-	-	PUNCT
afs-72863	147	31	like	like	ADJ
afs-72863	147	32	structure	structure	NOUN
afs-72863	147	33	of	of	ADP
afs-72863	147	34	three	three	NUM
afs-72863	147	35	orfs	orf	NOUN
afs-72863	147	36	.	.	PUNCT
afs-72863	148	1	orfi	orfi	PROPN
afs-72863	148	2	was	be	AUX
afs-72863	148	3	preceded	precede	VERB
afs-72863	148	4	by	by	ADP
afs-72863	148	5	a	a	DET
afs-72863	148	6	typical	typical	ADJ
afs-72863	148	7	prokaryotic	prokaryotic	ADJ
afs-72863	148	8	promoter	promoter	NOUN
afs-72863	148	9	region	region	NOUN
afs-72863	148	10	,	,	PUNCT
afs-72863	148	11	and	and	CCONJ
afs-72863	148	12	a	a	DET
afs-72863	148	13	putative	putative	ADJ
afs-72863	148	14	transcription	transcription	NOUN
afs-72863	148	15	terminator	terminator	NOUN
afs-72863	148	16	identified	identify	VERB
afs-72863	148	17	as	as	ADP
afs-72863	148	18	the	the	DET
afs-72863	148	19	pepl	pepl	NOUN
afs-72863	148	20	gene	gene	NOUN
afs-72863	148	21	was	be	AUX
afs-72863	148	22	present	present	ADJ
afs-72863	148	23	downstream	downstream	ADV
afs-72863	148	24	of	of	ADP
afs-72863	148	25	orf3	orf3	PROPN
afs-72863	148	26	.	.	PUNCT
afs-72863	149	1	primer	primer	NOUN
afs-72863	149	2	extension	extension	NOUN
afs-72863	149	3	analyses	analysis	NOUN
afs-72863	149	4	on	on	ADP
afs-72863	149	5	each	each	DET
afs-72863	149	6	orf	orf	PROPN
afs-72863	149	7	revealed	reveal	VERB
afs-72863	149	8	only	only	ADV
afs-72863	149	9	one	one	NUM
afs-72863	149	10	transcription	transcription	NOUN
afs-72863	149	11	start	start	VERB
afs-72863	149	12	site	site	NOUN
afs-72863	149	13	,	,	PUNCT
afs-72863	149	14	upstream	upstream	NOUN
afs-72863	149	15	of	of	ADP
afs-72863	149	16	orfi	orfi	NOUN
afs-72863	149	17	,	,	PUNCT
afs-72863	149	18	indicating	indicate	VERB
afs-72863	149	19	an	an	DET
afs-72863	149	20	operon	operon	ADJ
afs-72863	149	21	structure	structure	NOUN
afs-72863	149	22	.	.	PUNCT
afs-72863	150	1	the	the	DET
afs-72863	150	2	level	level	NOUN
afs-72863	150	3	of	of	ADP
afs-72863	150	4	operon	operon	ADJ
afs-72863	150	5	derived	derived	ADJ
afs-72863	150	6	transcripts	transcript	NOUN
afs-72863	150	7	was	be	AUX
afs-72863	150	8	so	so	ADV
afs-72863	150	9	low	low	ADJ
afs-72863	150	10	that	that	SCONJ
afs-72863	150	11	we	we	PRON
afs-72863	150	12	could	could	AUX
afs-72863	150	13	not	not	PART
afs-72863	150	14	determine	determine	VERB
afs-72863	150	15	the	the	DET
afs-72863	150	16	transcript	transcript	NOUN
afs-72863	150	17	size	size	NOUN
afs-72863	150	18	by	by	ADP
afs-72863	150	19	northern	northern	ADJ
afs-72863	150	20	blot	blot	NOUN
afs-72863	150	21	;	;	PUNCT
afs-72863	150	22	nevertheless	nevertheless	ADV
afs-72863	150	23	the	the	DET
afs-72863	150	24	rt	rt	NOUN
afs-72863	150	25	-	-	PUNCT
afs-72863	150	26	pcr	pcr	NOUN
afs-72863	150	27	clearly	clearly	ADV
afs-72863	150	28	supported	support	VERB
afs-72863	150	29	the	the	DET
afs-72863	150	30	operon	operon	ADJ
afs-72863	150	31	structure	structure	NOUN
afs-72863	150	32	of	of	ADP
afs-72863	150	33	these	these	DET
afs-72863	150	34	three	three	NUM
afs-72863	150	35	genes	gene	NOUN
afs-72863	150	36	.	.	PUNCT
afs-72863	151	1	the	the	DET
afs-72863	151	2	coding	code	VERB
afs-72863	151	3	capacities	capacity	NOUN
afs-72863	151	4	of	of	ADP
afs-72863	151	5	orfi	orfi	NOUN
afs-72863	151	6	,	,	PUNCT
afs-72863	151	7	orf2	orf2	PROPN
afs-72863	151	8	and	and	CCONJ
afs-72863	151	9	orf3	orf3	NOUN
afs-72863	151	10	were	be	AUX
afs-72863	151	11	for	for	ADP
afs-72863	151	12	50.7	50.7	NUM
afs-72863	151	13	,	,	PUNCT
afs-72863	151	14	24.5	24.5	NUM
afs-72863	151	15	and	and	CCONJ
afs-72863	151	16	33.8	33.8	NUM
afs-72863	151	17	kda	kda	NOUN
afs-72863	151	18	proteins	protein	NOUN
afs-72863	151	19	,	,	PUNCT
afs-72863	151	20	respectively	respectively	ADV
afs-72863	151	21	.	.	PUNCT
afs-72863	152	1	the	the	DET
afs-72863	152	2	orf3	orf3	NOUN
afs-72863	152	3	-	-	PUNCT
afs-72863	152	4	encoded	encode	VERB
afs-72863	152	5	pepl	pepl	NOUN
afs-72863	152	6	protein	protein	NOUN
afs-72863	152	7	showed	show	VERB
afs-72863	152	8	65	65	NUM
afs-72863	152	9	%	%	NOUN
afs-72863	152	10	identity	identity	NOUN
afs-72863	152	11	to	to	ADP
afs-72863	152	12	the	the	DET
afs-72863	152	13	pepl	pepl	NOUN
afs-72863	152	14	proteins	protein	NOUN
afs-72863	152	15	from	from	ADP
afs-72863	152	16	l.	l.	PROPN
afs-72863	152	17	delbrueckii	delbrueckii	PROPN
afs-72863	152	18	subsp	subsp	PROPN
afs-72863	152	19	.	.	PUNCT
afs-72863	153	1	hulgaricus	hulgaricus	NOUN
afs-72863	153	2	(	(	PUNCT
afs-72863	153	3	allan	allan	PROPN
afs-72863	153	4	et	et	PROPN
afs-72863	153	5	al	al	PROPN
afs-72863	153	6	.	.	PROPN
afs-72863	153	7	1994	1994	NUM
afs-72863	153	8	)	)	PUNCT
afs-72863	153	9	and	and	CCONJ
afs-72863	153	10	l.	l.	PROPN
afs-72863	153	11	delbrueckii	delbrueckii	PROPN
afs-72863	153	12	subsp	subsp	PROPN
afs-72863	153	13	.	.	PUNCT
afs-72863	154	1	lactis	lactis	PROPN
afs-72863	154	2	(	(	PUNCT
afs-72863	154	3	klein	klein	PROPN
afs-72863	154	4	et	et	PROPN
afs-72863	154	5	al	al	PROPN
afs-72863	154	6	.	.	PROPN
afs-72863	154	7	1994	1994	NUM
afs-72863	154	8	)	)	PUNCT
afs-72863	154	9	.	.	PUNCT
afs-72863	155	1	the	the	DET
afs-72863	155	2	pepl	pepl	PROPN
afs-72863	155	3	gene	gene	NOUN
afs-72863	155	4	was	be	AUX
afs-72863	155	5	overexpressed	overexpresse	VERB
afs-72863	155	6	in	in	ADP
afs-72863	155	7	e.	e.	PROPN
afs-72863	155	8	coli	coli	PROPN
afs-72863	155	9	and	and	CCONJ
afs-72863	155	10	purified	purify	VERB
afs-72863	155	11	to	to	ADP
afs-72863	155	12	homogeneity	homogeneity	NOUN
afs-72863	155	13	in	in	ADP
afs-72863	155	14	two	two	NUM
afs-72863	155	15	chromatographic	chromatographic	ADJ
afs-72863	155	16	steps	step	NOUN
afs-72863	155	17	(	(	PUNCT
afs-72863	155	18	varmanen	varmanen	NOUN
afs-72863	155	19	et	et	PROPN
afs-72863	155	20	al	al	PROPN
afs-72863	155	21	.	.	PROPN
afs-72863	155	22	1996b	1996b	NUM
afs-72863	155	23	)	)	PUNCT
afs-72863	155	24	.	.	PUNCT
afs-72863	156	1	pepl	pepl	PROPN
afs-72863	156	2	was	be	AUX
afs-72863	156	3	shown	show	VERB
afs-72863	156	4	to	to	PART
afs-72863	156	5	be	be	AUX
afs-72863	156	6	a	a	DET
afs-72863	156	7	dimer	dimer	NOUN
afs-72863	156	8	with	with	ADP
afs-72863	156	9	optimum	optimum	ADJ
afs-72863	156	10	activity	activity	NOUN
afs-72863	156	11	at	at	ADP
afs-72863	156	12	ph7.5	ph7.5	NUM
afs-72863	156	13	and	and	CCONJ
afs-72863	156	14	40	40	NUM
afs-72863	156	15	°	°	NOUN
afs-72863	156	16	c	c	NOUN
afs-72863	156	17	.	.	PUNCT
afs-72863	157	1	like	like	ADP
afs-72863	157	2	the	the	DET
afs-72863	157	3	l.	l.	PROPN
afs-72863	157	4	delbrueckii	delbrueckii	PROPN
afs-72863	157	5	pepls	pepls	PROPN
afs-72863	157	6	,	,	PUNCT
afs-72863	157	7	the	the	DET
afs-72863	157	8	l.	l.	PROPN
afs-72863	157	9	helveticus	helveticus	PROPN
afs-72863	157	10	pepl	pepl	PROPN
afs-72863	157	11	was	be	AUX
afs-72863	157	12	found	find	VERB
afs-72863	157	13	to	to	PART
afs-72863	157	14	be	be	AUX
afs-72863	157	15	a	a	DET
afs-72863	157	16	metal	metal	NOUN
afs-72863	157	17	-	-	PUNCT
afs-72863	157	18	independent	independent	NOUN
afs-72863	157	19	serinepeptidase	serinepeptidase	NOUN
afs-72863	157	20	with	with	ADP
afs-72863	157	21	thiol	thiol	ADJ
afs-72863	157	22	group	group	NOUN
afs-72863	157	23	at	at	ADP
afs-72863	157	24	or	or	CCONJ
afs-72863	157	25	near	near	ADP
afs-72863	157	26	the	the	DET
afs-72863	157	27	active	active	ADJ
afs-72863	157	28	site	site	NOUN
afs-72863	157	29	.	.	PUNCT
afs-72863	158	1	kinetic	kinetic	ADJ
afs-72863	158	2	studies	study	NOUN
afs-72863	158	3	with	with	ADP
afs-72863	158	4	propna	propna	NOUN
afs-72863	158	5	as	as	ADP
afs-72863	158	6	substrate	substrate	NOUN
afs-72863	158	7	revealed	reveal	VERB
afs-72863	158	8	k	k	PROPN
afs-72863	158	9	m	m	PROPN
afs-72863	158	10	and	and	CCONJ
afs-72863	158	11	v	v	ADP
afs-72863	158	12	values	value	NOUN
afs-72863	158	13	of	of	ADP
afs-72863	158	14	o.bmm	o.bmm	PROPN
afs-72863	158	15	and	and	CCONJ
afs-72863	158	16	350	350	NUM
afs-72863	158	17	mmol	mmol	NOUN
afs-72863	158	18	min	min	NOUN
afs-72863	158	19	1max	1max	NUM
afs-72863	158	20	mg	mg	NOUN
afs-72863	158	21	'	'	PUNCT
afs-72863	158	22	,	,	PUNCT
afs-72863	158	23	respectively	respectively	ADV
afs-72863	158	24	and	and	CCONJ
afs-72863	158	25	a	a	DET
afs-72863	158	26	very	very	ADV
afs-72863	158	27	high	high	ADJ
afs-72863	158	28	turnover	turnover	NOUN
afs-72863	158	29	number	number	NOUN
afs-72863	158	30	,	,	PUNCT
afs-72863	158	31	135	135	NUM
afs-72863	158	32	000	000	NUM
afs-72863	158	33	s	s	PART
afs-72863	158	34	'	'	NUM
afs-72863	158	35	.	.	PUNCT
afs-72863	159	1	the	the	DET
afs-72863	159	2	substrate	substrate	NOUN
afs-72863	159	3	specificities	specificity	NOUN
afs-72863	159	4	of	of	ADP
afs-72863	159	5	the	the	DET
afs-72863	159	6	three	three	NUM
afs-72863	159	7	pepls	pepls	NOUN
afs-72863	159	8	identified	identify	VERB
afs-72863	159	9	differed	differ	VERB
afs-72863	159	10	from	from	ADP
afs-72863	159	11	each	each	DET
afs-72863	159	12	other	other	ADJ
afs-72863	159	13	to	to	ADP
afs-72863	159	14	some	some	DET
afs-72863	159	15	extent	extent	NOUN
afs-72863	159	16	(	(	PUNCT
afs-72863	159	17	varmanen	varmanen	NOUN
afs-72863	159	18	et	et	PROPN
afs-72863	159	19	al	al	PROPN
afs-72863	159	20	.	.	PROPN
afs-72863	159	21	1996b	1996b	NUM
afs-72863	159	22	)	)	PUNCT
afs-72863	159	23	,	,	PUNCT
afs-72863	159	24	but	but	CCONJ
afs-72863	159	25	we	we	PRON
afs-72863	159	26	do	do	AUX
afs-72863	159	27	not	not	PART
afs-72863	159	28	know	know	VERB
afs-72863	159	29	whether	whether	SCONJ
afs-72863	159	30	these	these	DET
afs-72863	159	31	differences	difference	NOUN
afs-72863	159	32	were	be	AUX
afs-72863	159	33	due	due	ADJ
afs-72863	159	34	to	to	PART
afs-72863	159	35	assay	assay	VERB
afs-72863	159	36	conditions	condition	NOUN
afs-72863	159	37	or	or	CCONJ
afs-72863	159	38	they	they	PRON
afs-72863	159	39	were	be	AUX
afs-72863	159	40	true	true	ADJ
afs-72863	159	41	differences	difference	NOUN
afs-72863	159	42	in	in	ADP
afs-72863	159	43	the	the	DET
afs-72863	159	44	enzymatic	enzymatic	ADJ
afs-72863	159	45	properties	property	NOUN
afs-72863	159	46	of	of	ADP
afs-72863	159	47	these	these	DET
afs-72863	159	48	pepls	pepls	NOUN
afs-72863	159	49	.	.	PUNCT
afs-72863	160	1	the	the	DET
afs-72863	160	2	orfi	orfi	NOUN
afs-72863	160	3	and	and	CCONJ
afs-72863	160	4	orf2	orf2	ADJ
afs-72863	160	5	encoded	encode	VERB
afs-72863	160	6	proteins	protein	NOUN
afs-72863	160	7	were	be	AUX
afs-72863	160	8	found	find	VERB
afs-72863	160	9	to	to	PART
afs-72863	160	10	share	share	VERB
afs-72863	160	11	homology	homology	NOUN
afs-72863	160	12	with	with	ADP
afs-72863	160	13	the	the	DET
afs-72863	160	14	members	member	NOUN
afs-72863	160	15	of	of	ADP
afs-72863	160	16	273	273	NUM
afs-72863	160	17	vol	vol	NOUN
afs-72863	160	18	.	.	PUNCT
afs-72863	161	1	7(1998	7(1998	NUM
afs-72863	161	2	):	):	PUNCT
afs-72863	161	3	267	267	NUM
afs-72863	161	4	-	-	SYM
afs-72863	161	5	282	282	NUM
afs-72863	161	6	.	.	PUNCT
afs-72863	162	1	agricultural	agricultural	ADJ
afs-72863	162	2	and	and	CCONJ
afs-72863	162	3	food	food	NOUN
afs-72863	162	4	science	science	NOUN
afs-72863	162	5	in	in	ADP
afs-72863	162	6	finland	finland	PROPN
afs-72863	162	7	4	4	NUM
afs-72863	162	8	the	the	DET
afs-72863	162	9	abc	abc	PROPN
afs-72863	162	10	(	(	PUNCT
afs-72863	162	11	atp	atp	NOUN
afs-72863	162	12	binding	bind	VERB
afs-72863	162	13	casette	casette	NOUN
afs-72863	162	14	)	)	PUNCT
afs-72863	162	15	transporter	transporter	NOUN
afs-72863	162	16	family	family	NOUN
afs-72863	162	17	but	but	CCONJ
afs-72863	162	18	to	to	PART
afs-72863	162	19	represent	represent	VERB
afs-72863	162	20	an	an	DET
afs-72863	162	21	unusual	unusual	ADJ
afs-72863	162	22	type	type	NOUN
afs-72863	162	23	(	(	PUNCT
afs-72863	162	24	orf1	orf1	NOUN
afs-72863	162	25	)	)	PUNCT
afs-72863	162	26	among	among	ADP
afs-72863	162	27	the	the	DET
afs-72863	162	28	bacterial	bacterial	ADJ
afs-72863	162	29	abc	abc	PROPN
afs-72863	162	30	transporters	transporter	NOUN
afs-72863	162	31	(	(	PUNCT
afs-72863	162	32	varmanen	varmanen	NOUN
afs-72863	162	33	et	et	PROPN
afs-72863	162	34	al	al	PROPN
afs-72863	162	35	.	.	PROPN
afs-72863	162	36	1996b	1996b	NUM
afs-72863	162	37	)	)	PUNCT
afs-72863	162	38	.	.	PUNCT
afs-72863	163	1	proline	proline	NOUN
afs-72863	163	2	specific	specific	ADJ
afs-72863	163	3	peptidases	peptidase	NOUN
afs-72863	163	4	of	of	ADP
afs-72863	163	5	l	l	PROPN
afs-72863	163	6	delbrueckii	delbrueckii	PROPN
afs-72863	163	7	subsp	subsp	NOUN
afs-72863	163	8	.	.	PUNCT
afs-72863	164	1	bulgaricus	bulgaricus	NOUN
afs-72863	164	2	due	due	ADP
afs-72863	164	3	to	to	ADP
afs-72863	164	4	the	the	DET
afs-72863	164	5	importance	importance	NOUN
afs-72863	164	6	of	of	ADP
afs-72863	164	7	proline	proline	NOUN
afs-72863	164	8	-	-	PUNCT
afs-72863	164	9	specific	specific	ADJ
afs-72863	164	10	peptidases	peptidase	NOUN
afs-72863	164	11	we	we	PRON
afs-72863	164	12	have	have	AUX
afs-72863	164	13	also	also	ADV
afs-72863	164	14	characterised	characterise	VERB
afs-72863	164	15	two	two	NUM
afs-72863	164	16	genes	gene	NOUN
afs-72863	164	17	,	,	PUNCT
afs-72863	164	18	pepq	pepq	NOUN
afs-72863	164	19	and	and	CCONJ
afs-72863	164	20	orfz	orfz	NOUN
afs-72863	164	21	,	,	PUNCT
afs-72863	164	22	encoding	encode	VERB
afs-72863	164	23	a	a	DET
afs-72863	164	24	prolidase	prolidase	NOUN
afs-72863	164	25	(	(	PUNCT
afs-72863	164	26	pepq	pepq	NOUN
afs-72863	164	27	)	)	PUNCT
afs-72863	164	28	and	and	CCONJ
afs-72863	164	29	a	a	DET
afs-72863	164	30	pepq	pepq	NOUN
afs-72863	164	31	-	-	PUNCT
afs-72863	164	32	like	like	ADJ
afs-72863	164	33	protein	protein	NOUN
afs-72863	164	34	from	from	ADP
afs-72863	164	35	l.	l.	PROPN
afs-72863	164	36	delbrueckii	delbrueckii	PROPN
afs-72863	164	37	subsp	subsp	PROPN
afs-72863	164	38	.	.	PUNCT
afs-72863	165	1	bulgaricus	bulgaricus	NOUN
afs-72863	165	2	(	(	PUNCT
afs-72863	165	3	rantanen	rantanen	NOUN
afs-72863	165	4	and	and	CCONJ
afs-72863	165	5	palva	palva	NOUN
afs-72863	165	6	1997	1997	NUM
afs-72863	165	7	)	)	PUNCT
afs-72863	165	8	.	.	PUNCT
afs-72863	166	1	thepepq	thepepq	NOUN
afs-72863	166	2	and	and	CCONJ
afs-72863	166	3	orfz	orfz	NOUN
afs-72863	166	4	genes	gene	NOUN
afs-72863	166	5	showed	show	VERB
afs-72863	166	6	98	98	NUM
afs-72863	166	7	%	%	NOUN
afs-72863	166	8	and	and	CCONJ
afs-72863	166	9	60	60	NUM
afs-72863	166	10	%	%	NOUN
afs-72863	166	11	identity	identity	NOUN
afs-72863	166	12	,	,	PUNCT
afs-72863	166	13	respectively	respectively	ADV
afs-72863	166	14	to	to	ADP
afs-72863	166	15	the	the	DET
afs-72863	166	16	l.	l.	PROPN
afs-72863	166	17	delbrueckii	delbrueckii	PROPN
afs-72863	166	18	subsp	subsp	PROPN
afs-72863	166	19	.	.	PUNCT
afs-72863	167	1	lactis	lactis	PROPN
afs-72863	167	2	pepq	pepq	NOUN
afs-72863	167	3	;	;	PUNCT
afs-72863	167	4	both	both	CCONJ
afs-72863	167	5	pepq	pepq	NOUN
afs-72863	167	6	and	and	CCONJ
afs-72863	167	7	orfz	orfz	NOUN
afs-72863	167	8	were	be	AUX
afs-72863	167	9	preceded	precede	VERB
afs-72863	167	10	by	by	ADP
afs-72863	167	11	a	a	DET
afs-72863	167	12	putative	putative	ADJ
afs-72863	167	13	promoter	promoter	NOUN
afs-72863	167	14	region	region	NOUN
afs-72863	167	15	.	.	PUNCT
afs-72863	168	1	the	the	DET
afs-72863	168	2	size	size	NOUN
afs-72863	168	3	of	of	ADP
afs-72863	168	4	pepq	pepq	PROPN
afs-72863	168	5	mrna	mrna	PROPN
afs-72863	168	6	could	could	AUX
afs-72863	168	7	be	be	AUX
afs-72863	168	8	identified	identify	VERB
afs-72863	168	9	(	(	PUNCT
afs-72863	168	10	1.1	1.1	NUM
afs-72863	168	11	kb	kb	NOUN
afs-72863	168	12	)	)	PUNCT
afs-72863	168	13	but	but	CCONJ
afs-72863	168	14	,	,	PUNCT
afs-72863	168	15	under	under	ADP
afs-72863	168	16	the	the	DET
afs-72863	168	17	growth	growth	NOUN
afs-72863	168	18	conditions	condition	NOUN
afs-72863	168	19	used	use	VERB
afs-72863	168	20	,	,	PUNCT
afs-72863	168	21	we	we	PRON
afs-72863	168	22	could	could	AUX
afs-72863	168	23	only	only	ADV
afs-72863	168	24	identify	identify	VERB
afs-72863	168	25	the	the	DET
afs-72863	168	26	expression	expression	NOUN
afs-72863	168	27	of	of	ADP
afs-72863	168	28	orfz	orfz	NOUN
afs-72863	168	29	by	by	ADP
afs-72863	168	30	rt	rt	NOUN
afs-72863	168	31	-	-	PUNCT
afs-72863	168	32	pcr	pcr	NOUN
afs-72863	168	33	.	.	PUNCT
afs-72863	169	1	both	both	DET
afs-72863	169	2	genes	gene	NOUN
afs-72863	169	3	were	be	AUX
afs-72863	169	4	shown	show	VERB
afs-72863	169	5	to	to	PART
afs-72863	169	6	be	be	AUX
afs-72863	169	7	monocistronic	monocistronic	ADJ
afs-72863	169	8	transcriptional	transcriptional	ADJ
afs-72863	169	9	units	unit	NOUN
afs-72863	169	10	.	.	PUNCT
afs-72863	170	1	the	the	DET
afs-72863	170	2	orfz	orfz	NOUN
afs-72863	170	3	protein	protein	NOUN
afs-72863	170	4	,	,	PUNCT
afs-72863	170	5	overexpressed	overexpresse	VERB
afs-72863	170	6	in	in	ADP
afs-72863	170	7	e.	e.	PROPN
afs-72863	170	8	coll	coll	PROPN
afs-72863	170	9	,	,	PUNCT
afs-72863	170	10	revealed	reveal	VERB
afs-72863	170	11	no	no	DET
afs-72863	170	12	enzymatic	enzymatic	ADJ
afs-72863	170	13	activity	activity	NOUN
afs-72863	170	14	against	against	ADP
afs-72863	170	15	the	the	DET
afs-72863	170	16	peptide	peptide	NOUN
afs-72863	170	17	substrates	substrate	NOUN
afs-72863	170	18	tested	test	VERB
afs-72863	170	19	whereas	whereas	SCONJ
afs-72863	170	20	the	the	DET
afs-72863	170	21	l.	l.	PROPN
afs-72863	170	22	delbrueckii	delbrueckii	PROPN
afs-72863	170	23	subsp	subsp	PROPN
afs-72863	170	24	.	.	PUNCT
afs-72863	171	1	bulgaricus	bulgaricus	NOUN
afs-72863	171	2	pepq	pepq	NOUN
afs-72863	171	3	hydrolysed	hydrolysed	ADJ
afs-72863	171	4	x	x	ADJ
afs-72863	171	5	-	-	ADJ
afs-72863	171	6	pro	pro	ADJ
afs-72863	171	7	substrates	substrate	NOUN
afs-72863	171	8	similarly	similarly	ADV
afs-72863	171	9	to	to	ADP
afs-72863	171	10	other	other	ADJ
afs-72863	171	11	prolidases	prolidase	NOUN
afs-72863	171	12	.	.	PUNCT
afs-72863	172	1	note	note	VERB
afs-72863	172	2	that	that	SCONJ
afs-72863	172	3	homologues	homologue	NOUN
afs-72863	172	4	of	of	ADP
afs-72863	172	5	the	the	DET
afs-72863	172	6	l.	l.	PROPN
afs-72863	172	7	delbrueckii	delbrueckii	PROPN
afs-72863	172	8	subsp	subsp	PROPN
afs-72863	172	9	.	.	PUNCT
afs-72863	173	1	bulgaricus	bulgaricus	NOUN
afs-72863	173	2	orfz	orfz	NOUN
afs-72863	173	3	and	and	CCONJ
afs-72863	173	4	pepq	pepq	NOUN
afs-72863	173	5	genes	gene	NOUN
afs-72863	173	6	appeared	appear	VERB
afs-72863	173	7	to	to	PART
afs-72863	173	8	be	be	AUX
afs-72863	173	9	present	present	ADJ
afs-72863	173	10	in	in	ADP
afs-72863	173	11	both	both	DET
afs-72863	173	12	l.	l.	PROPN
afs-72863	173	13	delbrueckii	delbrueckii	PROPN
afs-72863	173	14	subsp	subsp	PROPN
afs-72863	173	15	.	.	PUNCT
afs-72863	174	1	lactis	lactis	PROPN
afs-72863	174	2	and	and	CCONJ
afs-72863	174	3	l.	l.	PROPN
afs-72863	174	4	helveticus	helveticus	PROPN
afs-72863	174	5	(	(	PUNCT
afs-72863	174	6	rantanen	rantanen	NOUN
afs-72863	174	7	and	and	CCONJ
afs-72863	174	8	palva	palva	NOUN
afs-72863	174	9	1997	1997	NUM
afs-72863	174	10	)	)	PUNCT
afs-72863	174	11	.	.	PUNCT
afs-72863	175	1	the	the	DET
afs-72863	175	2	role	role	NOUN
afs-72863	175	3	of	of	ADP
afs-72863	175	4	the	the	DET
afs-72863	175	5	cryptic	cryptic	ADJ
afs-72863	175	6	orfz	orfz	NOUN
afs-72863	175	7	gene	gene	NOUN
afs-72863	175	8	and	and	CCONJ
afs-72863	175	9	its	its	PRON
afs-72863	175	10	putative	putative	ADJ
afs-72863	175	11	gene	gene	NOUN
afs-72863	175	12	product	product	NOUN
afs-72863	175	13	remains	remain	VERB
afs-72863	175	14	to	to	PART
afs-72863	175	15	be	be	AUX
afs-72863	175	16	established	establish	VERB
afs-72863	175	17	.	.	PUNCT
afs-72863	176	1	oligopeptide	oligopeptide	NOUN
afs-72863	176	2	transport	transport	NOUN
afs-72863	176	3	system	system	NOUN
afs-72863	176	4	of	of	ADP
afs-72863	176	5	l	l	PROPN
afs-72863	176	6	delbrueckii	delbrueckii	PROPN
afs-72863	176	7	subsp	subsp	NOUN
afs-72863	176	8	.	.	PUNCT
afs-72863	177	1	bulgaricus	bulgaricus	VERB
afs-72863	177	2	as	as	ADV
afs-72863	177	3	well	well	ADV
afs-72863	177	4	as	as	ADP
afs-72863	177	5	reforming	reform	VERB
afs-72863	177	6	peptidase	peptidase	NOUN
afs-72863	177	7	analyses	analysis	NOUN
afs-72863	177	8	,	,	PUNCT
afs-72863	177	9	we	we	PRON
afs-72863	177	10	have	have	AUX
afs-72863	177	11	started	start	VERB
afs-72863	177	12	the	the	DET
afs-72863	177	13	characterisation	characterisation	NOUN
afs-72863	177	14	ofother	ofother	ADJ
afs-72863	177	15	components	component	NOUN
afs-72863	177	16	of	of	ADP
afs-72863	177	17	the	the	DET
afs-72863	177	18	proteolytic	proteolytic	ADJ
afs-72863	177	19	systems	system	NOUN
afs-72863	177	20	ofthermophilic	ofthermophilic	ADJ
afs-72863	177	21	lactobacilli	lactobacilli	NOUN
afs-72863	177	22	.	.	PUNCT
afs-72863	178	1	we	we	PRON
afs-72863	178	2	have	have	AUX
afs-72863	178	3	isolated	isolate	VERB
afs-72863	178	4	the	the	DET
afs-72863	178	5	operon	operon	NOUN
afs-72863	178	6	of	of	ADP
afs-72863	178	7	the	the	DET
afs-72863	178	8	oligopeptide	oligopeptide	NOUN
afs-72863	178	9	transport	transport	NOUN
afs-72863	178	10	system	system	NOUN
afs-72863	178	11	from	from	ADP
afs-72863	178	12	a	a	DET
afs-72863	178	13	lambda	lambda	ADJ
afs-72863	178	14	gtlo	gtlo	NOUN
afs-72863	178	15	based	base	VERB
afs-72863	178	16	genomic	genomic	NOUN
afs-72863	178	17	library	library	NOUN
afs-72863	178	18	of	of	ADP
afs-72863	178	19	l.	l.	PROPN
afs-72863	178	20	delbrueckii	delbrueckii	PROPN
afs-72863	178	21	subsp	subsp	PROPN
afs-72863	178	22	.	.	PUNCT
afs-72863	179	1	bulgaricus	bulgaricus	NOUN
afs-72863	179	2	(	(	PUNCT
afs-72863	179	3	peltoniemi	peltoniemi	NOUN
afs-72863	179	4	et	et	PROPN
afs-72863	179	5	al	al	PROPN
afs-72863	179	6	.	.	PROPN
afs-72863	179	7	1998	1998	NUM
afs-72863	179	8	unpublished	unpublished	ADJ
afs-72863	179	9	results	result	NOUN
afs-72863	179	10	)	)	PUNCT
afs-72863	179	11	.	.	PUNCT
afs-72863	180	1	this	this	DET
afs-72863	180	2	operon	operon	NOUN
afs-72863	180	3	is	be	AUX
afs-72863	180	4	6.1	6.1	NUM
afs-72863	180	5	kb	kb	NOUN
afs-72863	180	6	in	in	ADP
afs-72863	180	7	size	size	NOUN
afs-72863	180	8	and	and	CCONJ
afs-72863	180	9	consists	consist	VERB
afs-72863	180	10	of	of	ADP
afs-72863	180	11	five	five	NUM
afs-72863	180	12	genes	gene	NOUN
afs-72863	180	13	encoding	encode	VERB
afs-72863	180	14	the	the	DET
afs-72863	180	15	peptide	peptide	NOUN
afs-72863	180	16	binding	bind	VERB
afs-72863	180	17	protein	protein	NOUN
afs-72863	180	18	(	(	PUNCT
afs-72863	180	19	oppa	oppa	PROPN
afs-72863	180	20	)	)	PUNCT
afs-72863	180	21	,	,	PUNCT
afs-72863	180	22	two	two	NUM
afs-72863	180	23	integral	integral	ADJ
afs-72863	180	24	membrane	membrane	NOUN
afs-72863	180	25	proteins	protein	NOUN
afs-72863	180	26	(	(	PUNCT
afs-72863	180	27	oppß	oppß	NOUN
afs-72863	180	28	and	and	CCONJ
afs-72863	180	29	oppc	oppc	NOUN
afs-72863	180	30	)	)	PUNCT
afs-72863	180	31	and	and	CCONJ
afs-72863	180	32	two	two	NUM
afs-72863	180	33	atp	atp	NOUN
afs-72863	180	34	-	-	PUNCT
afs-72863	180	35	binding	bind	VERB
afs-72863	180	36	proteins	protein	NOUN
afs-72863	180	37	(	(	PUNCT
afs-72863	180	38	oppd	oppd	ADJ
afs-72863	180	39	and	and	CCONJ
afs-72863	180	40	oppf	oppf	ADJ
afs-72863	180	41	)	)	PUNCT
afs-72863	180	42	.	.	PUNCT
afs-72863	181	1	in	in	ADP
afs-72863	181	2	l.	l.	PROPN
afs-72863	181	3	delbrueckii	delbrueckii	PROPN
afs-72863	181	4	subsp	subsp	PROPN
afs-72863	181	5	.	.	PUNCT
afs-72863	182	1	hulgaricus	hulgaricus	PROPN
afs-72863	182	2	,	,	PUNCT
afs-72863	182	3	the	the	DET
afs-72863	182	4	opp	opp	PROPN
afs-72863	182	5	genes	gene	NOUN
afs-72863	182	6	in	in	ADP
afs-72863	182	7	the	the	DET
afs-72863	182	8	operon	operon	NOUN
afs-72863	182	9	are	be	AUX
afs-72863	182	10	organized	organize	VERB
afs-72863	182	11	in	in	ADP
afs-72863	182	12	much	much	ADV
afs-72863	182	13	the	the	DET
afs-72863	182	14	same	same	ADJ
afs-72863	182	15	way	way	NOUN
afs-72863	182	16	as	as	ADP
afs-72863	182	17	in	in	ADP
afs-72863	182	18	lactococcus	lactococcus	PROPN
afs-72863	182	19	lactis	lactis	PROPN
afs-72863	182	20	(	(	PUNCT
afs-72863	182	21	tynkkynen	tynkkynen	NOUN
afs-72863	182	22	et	et	PROPN
afs-72863	182	23	al	al	PROPN
afs-72863	182	24	.	.	PROPN
afs-72863	182	25	1993	1993	NUM
afs-72863	182	26	)	)	PUNCT
afs-72863	182	27	,	,	PUNCT
afs-72863	182	28	i.	i.	PROPN
afs-72863	182	29	e.	e.	PROPN
afs-72863	182	30	oppdfbca	oppdfbca	PROPN
afs-72863	182	31	.	.	PUNCT
afs-72863	183	1	interestingly	interestingly	ADV
afs-72863	183	2	,	,	PUNCT
afs-72863	183	3	an	an	DET
afs-72863	183	4	additional	additional	ADJ
afs-72863	183	5	oppa	oppa	NOUN
afs-72863	183	6	-	-	PUNCT
afs-72863	183	7	like	like	ADJ
afs-72863	183	8	gene	gene	NOUN
afs-72863	183	9	is	be	AUX
afs-72863	183	10	adjacent	adjacent	ADJ
afs-72863	183	11	to	to	ADP
afs-72863	183	12	the	the	DET
afs-72863	183	13	oppa	oppa	NOUN
afs-72863	183	14	of	of	ADP
afs-72863	183	15	the	the	DET
afs-72863	183	16	operon	operon	NOUN
afs-72863	183	17	.	.	PUNCT
afs-72863	184	1	the	the	DET
afs-72863	184	2	identity	identity	NOUN
afs-72863	184	3	of	of	ADP
afs-72863	184	4	the	the	DET
afs-72863	184	5	oppdfbca	oppdfbca	NOUN
afs-72863	184	6	to	to	ADP
afs-72863	184	7	that	that	PRON
afs-72863	184	8	ofl	ofl	PROPN
afs-72863	184	9	.	.	PROPN
afs-72863	184	10	lactis	lactis	PROPN
afs-72863	184	11	was	be	AUX
afs-72863	184	12	shown	show	VERB
afs-72863	184	13	to	to	PART
afs-72863	184	14	be	be	AUX
afs-72863	184	15	50	50	NUM
afs-72863	184	16	%	%	NOUN
afs-72863	184	17	,	,	PUNCT
afs-72863	184	18	65	65	NUM
afs-72863	184	19	%	%	NOUN
afs-72863	184	20	,	,	PUNCT
afs-72863	184	21	55	55	NUM
afs-72863	184	22	%	%	NOUN
afs-72863	184	23	,	,	PUNCT
afs-72863	184	24	40	40	NUM
afs-72863	184	25	%	%	NOUN
afs-72863	184	26	and	and	CCONJ
afs-72863	184	27	40	40	NUM
afs-72863	184	28	%	%	NOUN
afs-72863	184	29	,	,	PUNCT
afs-72863	184	30	respectively	respectively	ADV
afs-72863	184	31	(	(	PUNCT
afs-72863	184	32	peltoniemi	peltoniemi	NOUN
afs-72863	184	33	et	et	PROPN
afs-72863	184	34	al	al	PROPN
afs-72863	184	35	.	.	PROPN
afs-72863	184	36	1998	1998	NUM
afs-72863	184	37	,	,	PUNCT
afs-72863	184	38	unpublished	unpublished	ADJ
afs-72863	184	39	)	)	PUNCT
afs-72863	184	40	.	.	PUNCT
afs-72863	185	1	the	the	DET
afs-72863	185	2	operon	operon	NOUN
afs-72863	185	3	structure	structure	NOUN
afs-72863	185	4	deduced	deduce	VERB
afs-72863	185	5	from	from	ADP
afs-72863	185	6	the	the	DET
afs-72863	185	7	dna	dna	PROPN
afs-72863	185	8	sequence	sequence	NOUN
afs-72863	185	9	of	of	ADP
afs-72863	185	10	oppdfbca	oppdfbca	NOUN
afs-72863	185	11	has	have	AUX
afs-72863	185	12	also	also	ADV
afs-72863	185	13	been	be	AUX
afs-72863	185	14	confirmed	confirm	VERB
afs-72863	185	15	by	by	ADP
afs-72863	185	16	mrna	mrna	PROPN
afs-72863	185	17	analyses	analysis	NOUN
afs-72863	185	18	.	.	PUNCT
afs-72863	186	1	characterisation	characterisation	NOUN
afs-72863	186	2	of	of	ADP
afs-72863	186	3	surface	surface	NOUN
afs-72863	186	4	layer	layer	NOUN
afs-72863	186	5	protein	protein	NOUN
afs-72863	186	6	and	and	CCONJ
afs-72863	186	7	gene	gene	NOUN
afs-72863	186	8	(	(	PUNCT
afs-72863	186	9	sipa	sipa	NOUN
afs-72863	186	10	)	)	PUNCT
afs-72863	186	11	from	from	ADP
afs-72863	186	12	lactobacillus	lactobacillus	NOUN
afs-72863	186	13	brevis	brevis	NOUN
afs-72863	186	14	and	and	CCONJ
afs-72863	186	15	use	use	NOUN
afs-72863	186	16	of	of	ADP
afs-72863	186	17	sipa	sipa	ADJ
afs-72863	186	18	signals	signal	NOUN
afs-72863	186	19	for	for	ADP
afs-72863	186	20	heterologous	heterologous	ADJ
afs-72863	186	21	protein	protein	NOUN
afs-72863	186	22	production	production	NOUN
afs-72863	186	23	general	general	ADJ
afs-72863	186	24	background	background	NOUN
afs-72863	186	25	of	of	ADP
afs-72863	186	26	prokaryotic	prokaryotic	ADJ
afs-72863	186	27	s	s	NOUN
afs-72863	186	28	-	-	PUNCT
afs-72863	186	29	layer	layer	NOUN
afs-72863	186	30	structures	structure	NOUN
afs-72863	186	31	there	there	PRON
afs-72863	186	32	are	be	VERB
afs-72863	186	33	also	also	ADV
afs-72863	186	34	many	many	ADJ
afs-72863	186	35	lactobaci	lactobaci	NOUN
afs-72863	186	36	/	/	SYM
afs-72863	186	37	lus	lus	NOUN
afs-72863	186	38	-	-	PUNCT
afs-72863	186	39	species	species	NOUN
afs-72863	186	40	among	among	ADP
afs-72863	186	41	the	the	DET
afs-72863	186	42	over	over	ADP
afs-72863	186	43	300	300	NUM
afs-72863	186	44	s	s	NOUN
afs-72863	186	45	-	-	PUNCT
afs-72863	186	46	layer	layer	NOUN
afs-72863	186	47	harbouring	harbouring	NOUN
afs-72863	186	48	euand	euand	VERB
afs-72863	186	49	archaebacterial	archaebacterial	ADJ
afs-72863	186	50	species	specie	NOUN
afs-72863	186	51	(	(	PUNCT
afs-72863	186	52	messner	messner	NOUN
afs-72863	186	53	and	and	CCONJ
afs-72863	186	54	sleytr	sleytr	PROPN
afs-72863	186	55	1992	1992	NUM
afs-72863	186	56	)	)	PUNCT
afs-72863	186	57	.	.	PUNCT
afs-72863	187	1	the	the	DET
afs-72863	187	2	dna	dna	PROPN
afs-72863	187	3	sequence	sequence	NOUN
afs-72863	187	4	of	of	ADP
afs-72863	187	5	the	the	DET
afs-72863	187	6	lactobacillar	lactobacillar	ADJ
afs-72863	187	7	s	s	NOUN
afs-72863	187	8	-	-	ADJ
afs-72863	187	9	protein	protein	ADJ
afs-72863	187	10	gene	gene	NOUN
afs-72863	187	11	(	(	PUNCT
afs-72863	187	12	sip	sip	NOUN
afs-72863	187	13	)	)	PUNCT
afs-72863	187	14	has	have	AUX
afs-72863	187	15	been	be	AUX
afs-72863	187	16	published	publish	VERB
afs-72863	187	17	for	for	ADP
afs-72863	187	18	l.	l.	PROPN
afs-72863	187	19	brevis	brevis	PROPN
afs-72863	187	20	,	,	PUNCT
afs-72863	187	21	l.	l.	PROPN
afs-72863	187	22	acidophilus	acidophilus	PROPN
afs-72863	187	23	and	and	CCONJ
afs-72863	187	24	l.	l.	PROPN
afs-72863	187	25	helveticus	helveticus	PROPN
afs-72863	187	26	.	.	PUNCT
afs-72863	188	1	the	the	DET
afs-72863	188	2	functions	function	NOUN
afs-72863	188	3	of	of	ADP
afs-72863	188	4	the	the	DET
afs-72863	188	5	lactobacillar	lactobacillar	ADJ
afs-72863	188	6	s	s	NOUN
afs-72863	188	7	-	-	NOUN
afs-72863	188	8	layers	layer	NOUN
afs-72863	188	9	are	be	AUX
afs-72863	188	10	mostly	mostly	ADV
afs-72863	188	11	unknown	unknown	ADJ
afs-72863	188	12	,	,	PUNCT
afs-72863	188	13	but	but	CCONJ
afs-72863	188	14	apparently	apparently	ADV
afs-72863	188	15	this	this	DET
afs-72863	188	16	structure	structure	NOUN
afs-72863	188	17	is	be	AUX
afs-72863	188	18	essential	essential	ADJ
afs-72863	188	19	since	since	SCONJ
afs-72863	188	20	all	all	DET
afs-72863	188	21	attempts	attempt	NOUN
afs-72863	188	22	to	to	PART
afs-72863	188	23	inactivate	inactivate	VERB
afs-72863	188	24	sip	sip	NOUN
afs-72863	188	25	genes	gene	NOUN
afs-72863	188	26	have	have	AUX
afs-72863	188	27	failed	fail	VERB
afs-72863	188	28	(	(	PUNCT
afs-72863	188	29	boot	boot	NOUN
afs-72863	188	30	1996	1996	NUM
afs-72863	188	31	)	)	PUNCT
afs-72863	188	32	.	.	PUNCT
afs-72863	189	1	the	the	DET
afs-72863	189	2	l.	l.	PROPN
afs-72863	189	3	crispatus	crispatus	PROPN
afs-72863	189	4	s	s	NOUN
afs-72863	189	5	-	-	PUNCT
afs-72863	189	6	protein	protein	NOUN
afs-72863	189	7	has	have	AUX
afs-72863	189	8	been	be	AUX
afs-72863	189	9	shown	show	VERB
afs-72863	189	10	to	to	PART
afs-72863	189	11	mediate	mediate	VERB
afs-72863	189	12	adhesion	adhesion	NOUN
afs-72863	189	13	to	to	PART
afs-72863	189	14	type	type	VERB
afs-72863	189	15	iv	iv	NUM
afs-72863	189	16	collagen	collagen	NOUN
afs-72863	189	17	(	(	PUNCT
afs-72863	189	18	toba	toba	PROPN
afs-72863	189	19	et	et	PROPN
afs-72863	189	20	al	al	PROPN
afs-72863	189	21	.	.	PROPN
afs-72863	189	22	1995	1995	NUM
afs-72863	189	23	)	)	PUNCT
afs-72863	189	24	.	.	PUNCT
afs-72863	190	1	for	for	ADP
afs-72863	190	2	an	an	DET
afs-72863	190	3	average	average	ADJ
afs-72863	190	4	size	size	NOUN
afs-72863	190	5	cell	cell	NOUN
afs-72863	190	6	,	,	PUNCT
afs-72863	190	7	5	5	NUM
afs-72863	190	8	x	x	SYM
afs-72863	190	9	105	105	NUM
afs-72863	190	10	s	s	NOUN
afs-72863	190	11	-	-	PUNCT
afs-72863	190	12	layer	layer	NOUN
afs-72863	190	13	subunits	subunit	NOUN
afs-72863	190	14	have	have	VERB
afs-72863	190	15	to	to	PART
afs-72863	190	16	be	be	AUX
afs-72863	190	17	synthesised	synthesise	VERB
afs-72863	190	18	per	per	ADP
afs-72863	190	19	cell	cell	NOUN
afs-72863	190	20	generation	generation	NOUN
afs-72863	190	21	in	in	ADP
afs-72863	190	22	order	order	NOUN
afs-72863	190	23	to	to	PART
afs-72863	190	24	cover	cover	VERB
afs-72863	190	25	the	the	DET
afs-72863	190	26	entire	entire	ADJ
afs-72863	190	27	cell	cell	NOUN
afs-72863	190	28	surface	surface	NOUN
afs-72863	190	29	with	with	ADP
afs-72863	190	30	the	the	DET
afs-72863	190	31	274	274	NUM
afs-72863	190	32	seminar	seminar	NOUN
afs-72863	190	33	in	in	ADP
afs-72863	190	34	honour	honour	NOUN
afs-72863	190	35	of	of	ADP
afs-72863	190	36	the	the	DET
afs-72863	190	37	100th	100th	ADJ
afs-72863	190	38	anniversary	anniversary	NOUN
afs-72863	190	39	ofmtt	ofmtt	NOUN
afs-72863	190	40	agricultural	agricultural	ADJ
afs-72863	190	41	and	and	CCONJ
afs-72863	190	42	food	food	NOUN
afs-72863	190	43	science	science	NOUN
afs-72863	190	44	in	in	ADP
afs-72863	190	45	finland	finland	PROPN
afs-72863	190	46	s	s	PROPN
afs-72863	190	47	-	-	PUNCT
afs-72863	190	48	layer	layer	NOUN
afs-72863	190	49	proteins	protein	NOUN
afs-72863	190	50	(	(	PUNCT
afs-72863	190	51	messner	messner	NOUN
afs-72863	190	52	and	and	CCONJ
afs-72863	190	53	sleytr	sleytr	PROPN
afs-72863	190	54	1992	1992	NUM
afs-72863	190	55	)	)	PUNCT
afs-72863	190	56	.	.	PUNCT
afs-72863	191	1	the	the	DET
afs-72863	191	2	expression	expression	NOUN
afs-72863	191	3	of	of	ADP
afs-72863	191	4	a	a	DET
afs-72863	191	5	sip	sip	NOUN
afs-72863	191	6	gene	gene	NOUN
afs-72863	191	7	and	and	CCONJ
afs-72863	191	8	the	the	DET
afs-72863	191	9	secretion	secretion	NOUN
afs-72863	191	10	machinery	machinery	NOUN
afs-72863	191	11	of	of	ADP
afs-72863	191	12	an	an	DET
afs-72863	191	13	s	s	NOUN
afs-72863	191	14	-	-	PUNCT
afs-72863	191	15	layer	layer	NOUN
afs-72863	191	16	harbouring	harbouring	NOUN
afs-72863	191	17	cell	cell	NOUN
afs-72863	191	18	may	may	AUX
afs-72863	191	19	thus	thus	ADV
afs-72863	191	20	be	be	AUX
afs-72863	191	21	expected	expect	VERB
afs-72863	191	22	to	to	PART
afs-72863	191	23	be	be	AUX
afs-72863	191	24	very	very	ADV
afs-72863	191	25	efficient	efficient	ADJ
afs-72863	191	26	.	.	PUNCT
afs-72863	192	1	these	these	DET
afs-72863	192	2	properties	property	NOUN
afs-72863	192	3	are	be	AUX
afs-72863	192	4	obvious	obvious	ADJ
afs-72863	192	5	assets	asset	NOUN
afs-72863	192	6	in	in	ADP
afs-72863	192	7	the	the	DET
afs-72863	192	8	utilisationof	utilisationof	NOUN
afs-72863	192	9	s	s	NOUN
afs-72863	192	10	-	-	PUNCT
afs-72863	192	11	proteins	protein	NOUN
afs-72863	192	12	in	in	ADP
afs-72863	192	13	biotechnological	biotechnological	ADJ
afs-72863	192	14	applications	application	NOUN
afs-72863	192	15	.	.	PUNCT
afs-72863	193	1	we	we	PRON
afs-72863	193	2	chose	choose	VERB
afs-72863	193	3	to	to	PART
afs-72863	193	4	study	study	VERB
afs-72863	193	5	heterologous	heterologous	ADJ
afs-72863	193	6	protein	protein	NOUN
afs-72863	193	7	production	production	NOUN
afs-72863	193	8	in	in	ADP
afs-72863	193	9	lactic	lactic	ADJ
afs-72863	193	10	acid	acid	NOUN
afs-72863	193	11	bacteria	bacteria	NOUN
afs-72863	193	12	,	,	PUNCT
afs-72863	193	13	with	with	ADP
afs-72863	193	14	the	the	DET
afs-72863	193	15	l.	l.	PROPN
afs-72863	193	16	brevis	brevis	PROPN
afs-72863	193	17	slpa	slpa	NOUN
afs-72863	193	18	and	and	CCONJ
afs-72863	193	19	to	to	PART
afs-72863	193	20	test	test	VERB
afs-72863	193	21	the	the	DET
afs-72863	193	22	possibility	possibility	NOUN
afs-72863	193	23	ofusing	ofusing	NOUN
afs-72863	193	24	slpa	slpa	NOUN
afs-72863	193	25	as	as	ADP
afs-72863	193	26	a	a	DET
afs-72863	193	27	carrier	carrier	NOUN
afs-72863	193	28	for	for	ADP
afs-72863	193	29	foreign	foreign	ADJ
afs-72863	193	30	antigenic	antigenic	ADJ
afs-72863	193	31	epitopes	epitope	NOUN
afs-72863	193	32	.	.	PUNCT
afs-72863	194	1	l.	l.	PROPN
afs-72863	194	2	brevis	brevis	PROPN
afs-72863	194	3	is	be	AUX
afs-72863	194	4	a	a	DET
afs-72863	194	5	heterofermentative	heterofermentative	ADJ
afs-72863	194	6	lactic	lactic	ADJ
afs-72863	194	7	acid	acid	NOUN
afs-72863	194	8	bacterium	bacterium	NOUN
afs-72863	194	9	commonly	commonly	ADV
afs-72863	194	10	found	find	VERB
afs-72863	194	11	in	in	ADP
afs-72863	194	12	vegetable	vegetable	NOUN
afs-72863	194	13	fermentations	fermentation	NOUN
afs-72863	194	14	,	,	PUNCT
afs-72863	194	15	sour	sour	ADJ
afs-72863	194	16	dough	dough	NOUN
afs-72863	194	17	,	,	PUNCT
afs-72863	194	18	silage	silage	NOUN
afs-72863	194	19	and	and	CCONJ
afs-72863	194	20	the	the	DET
afs-72863	194	21	intestine	intestine	NOUN
afs-72863	194	22	of	of	ADP
afs-72863	194	23	humans	human	NOUN
afs-72863	194	24	and	and	CCONJ
afs-72863	194	25	animals	animal	NOUN
afs-72863	194	26	(	(	PUNCT
afs-72863	194	27	wood	wood	NOUN
afs-72863	194	28	1992	1992	NUM
afs-72863	194	29	)	)	PUNCT
afs-72863	194	30	.	.	PUNCT
afs-72863	195	1	here	here	ADV
afs-72863	195	2	,	,	PUNCT
afs-72863	195	3	i	i	PRON
afs-72863	195	4	shall	shall	AUX
afs-72863	195	5	look	look	VERB
afs-72863	195	6	briefly	briefly	ADV
afs-72863	195	7	at	at	ADP
afs-72863	195	8	characterisation	characterisation	NOUN
afs-72863	195	9	of	of	ADP
afs-72863	195	10	the	the	DET
afs-72863	195	11	l.	l.	PROPN
afs-72863	195	12	brevis	brevis	PROPN
afs-72863	195	13	s	s	PROPN
afs-72863	195	14	-	-	NOUN
afs-72863	195	15	protein	protein	NOUN
afs-72863	195	16	,	,	PUNCT
afs-72863	195	17	gene	gene	NOUN
afs-72863	195	18	,	,	PUNCT
afs-72863	195	19	mrna	mrna	NOUN
afs-72863	195	20	and	and	CCONJ
afs-72863	195	21	in	in	ADP
afs-72863	195	22	vivo	vivo	ADJ
afs-72863	195	23	expression	expression	NOUN
afs-72863	195	24	and	and	CCONJ
afs-72863	195	25	discuss	discuss	VERB
afs-72863	195	26	the	the	DET
afs-72863	195	27	demonstration	demonstration	NOUN
afs-72863	195	28	of	of	ADP
afs-72863	195	29	heterologous	heterologous	ADJ
afs-72863	195	30	protein	protein	NOUN
afs-72863	195	31	secretion	secretion	NOUN
afs-72863	195	32	and	and	CCONJ
afs-72863	195	33	intracellularproduction	intracellularproduction	NOUN
afs-72863	195	34	withof	withof	AUX
afs-72863	195	35	aid	aid	VERB
afs-72863	195	36	the	the	DET
afs-72863	195	37	slpa	slpa	ADJ
afs-72863	195	38	signals	signal	NOUN
afs-72863	195	39	.	.	PUNCT
afs-72863	196	1	characteristics	characteristic	NOUN
afs-72863	196	2	of	of	ADP
afs-72863	196	3	the	the	DET
afs-72863	196	4	l	l	NOUN
afs-72863	196	5	brevis	brevis	NOUN
afs-72863	196	6	s	s	NOUN
afs-72863	196	7	-	-	NOUN
afs-72863	196	8	protein	protein	NOUN
afs-72863	196	9	and	and	CCONJ
afs-72863	196	10	the	the	DET
afs-72863	196	11	slpa	slpa	ADJ
afs-72863	196	12	gene	gene	NOUN
afs-72863	196	13	we	we	PRON
afs-72863	196	14	demonstrated	demonstrate	VERB
afs-72863	196	15	the	the	DET
afs-72863	196	16	presence	presence	NOUN
afs-72863	196	17	of	of	ADP
afs-72863	196	18	the	the	DET
afs-72863	196	19	s	s	NOUN
afs-72863	196	20	-	-	NOUN
afs-72863	196	21	protein	protein	NOUN
afs-72863	196	22	in	in	ADP
afs-72863	196	23	intact	intact	ADJ
afs-72863	196	24	l.	l.	NOUN
afs-72863	196	25	brevis	brevis	PROPN
afs-72863	196	26	atcc	atcc	PROPN
afs-72863	196	27	8287	8287	NUM
afs-72863	196	28	cells	cell	NOUN
afs-72863	196	29	,	,	PUNCT
afs-72863	196	30	boiled	boil	VERB
afs-72863	196	31	in	in	ADP
afs-72863	196	32	laemmli	laemmli	NOUN
afs-72863	196	33	sample	sample	NOUN
afs-72863	196	34	buffer	buffer	NOUN
afs-72863	196	35	,	,	PUNCT
afs-72863	196	36	by	by	ADP
afs-72863	196	37	sds	sds	NOUN
afs-72863	196	38	-	-	PUNCT
afs-72863	196	39	page	page	NOUN
afs-72863	196	40	analysis	analysis	NOUN
afs-72863	196	41	,	,	PUNCT
afs-72863	196	42	which	which	PRON
afs-72863	196	43	revealed	reveal	VERB
afs-72863	196	44	only	only	ADV
afs-72863	196	45	one	one	NUM
afs-72863	196	46	major	major	ADJ
afs-72863	196	47	band	band	NOUN
afs-72863	196	48	,	,	PUNCT
afs-72863	196	49	with	with	ADP
afs-72863	196	50	an	an	DET
afs-72863	196	51	apparent	apparent	ADJ
afs-72863	196	52	molecular	molecular	ADJ
afs-72863	196	53	weight	weight	NOUN
afs-72863	196	54	of46	of46	PROPN
afs-72863	196	55	kda	kda	PROPN
afs-72863	196	56	(	(	PUNCT
afs-72863	196	57	vidgrén	vidgrén	VERB
afs-72863	196	58	et	et	PROPN
afs-72863	196	59	al	al	PROPN
afs-72863	196	60	.	.	PROPN
afs-72863	196	61	1992	1992	NUM
afs-72863	196	62	)	)	PUNCT
afs-72863	196	63	.	.	PUNCT
afs-72863	197	1	when	when	SCONJ
afs-72863	197	2	the	the	DET
afs-72863	197	3	cells	cell	NOUN
afs-72863	197	4	were	be	AUX
afs-72863	197	5	treated	treat	VERB
afs-72863	197	6	with	with	ADP
afs-72863	197	7	an	an	DET
afs-72863	197	8	antiserum	antiserum	NOUN
afs-72863	197	9	raised	raise	VERB
afs-72863	197	10	against	against	ADP
afs-72863	197	11	the	the	DET
afs-72863	197	12	isolated	isolate	VERB
afs-72863	197	13	46	46	NUM
afs-72863	197	14	kda	kda	NOUN
afs-72863	197	15	protein	protein	NOUN
afs-72863	197	16	and	and	CCONJ
afs-72863	197	17	analysed	analyse	VERB
afs-72863	197	18	by	by	ADP
afs-72863	197	19	immuno	immuno	ADJ
afs-72863	197	20	-	-	PUNCT
afs-72863	197	21	gold	gold	ADJ
afs-72863	197	22	electron	electron	NOUN
afs-72863	197	23	microscopy	microscopy	NOUN
afs-72863	197	24	,	,	PUNCT
afs-72863	197	25	post	post	NOUN
afs-72863	197	26	embedding	embed	VERB
afs-72863	197	27	immunoelectron	immunoelectron	ADJ
afs-72863	197	28	microscopy	microscopy	NOUN
afs-72863	197	29	clearly	clearly	ADV
afs-72863	197	30	showed	show	VERB
afs-72863	197	31	that	that	SCONJ
afs-72863	197	32	the	the	DET
afs-72863	197	33	46	46	NUM
afs-72863	197	34	kda	kda	NOUN
afs-72863	197	35	protein	protein	NOUN
afs-72863	197	36	was	be	AUX
afs-72863	197	37	heavily	heavily	ADV
afs-72863	197	38	concentrated	concentrated	ADJ
afs-72863	197	39	in	in	ADP
afs-72863	197	40	the	the	DET
afs-72863	197	41	outermost	outermost	ADJ
afs-72863	197	42	part	part	NOUN
afs-72863	197	43	of	of	ADP
afs-72863	197	44	the	the	DET
afs-72863	197	45	cell	cell	NOUN
afs-72863	197	46	wall	wall	PROPN
afs-72863	197	47	ofl	ofl	PROPN
afs-72863	197	48	.	.	PROPN
afs-72863	197	49	brevis	brevis	PROPN
afs-72863	197	50	cells	cell	NOUN
afs-72863	197	51	(	(	PUNCT
afs-72863	197	52	vidgrén	vidgrén	VERB
afs-72863	197	53	at	at	ADP
afs-72863	197	54	al	al	PROPN
afs-72863	197	55	.	.	PROPN
afs-72863	197	56	1992	1992	NUM
afs-72863	197	57	)	)	PUNCT
afs-72863	197	58	.	.	PUNCT
afs-72863	198	1	the	the	DET
afs-72863	198	2	slpa	slpa	ADJ
afs-72863	198	3	gene	gene	NOUN
afs-72863	198	4	was	be	AUX
afs-72863	198	5	pcr	pcr	NOUN
afs-72863	198	6	cloned	clone	VERB
afs-72863	198	7	according	accord	VERB
afs-72863	198	8	to	to	ADP
afs-72863	198	9	the	the	DET
afs-72863	198	10	n	n	CCONJ
afs-72863	198	11	-	-	PUNCT
afs-72863	198	12	terminal	terminal	ADJ
afs-72863	198	13	sequence	sequence	NOUN
afs-72863	198	14	information	information	NOUN
afs-72863	198	15	of	of	ADP
afs-72863	198	16	the	the	DET
afs-72863	198	17	intact	intact	ADJ
afs-72863	198	18	s	s	NOUN
afs-72863	198	19	-	-	ADJ
afs-72863	198	20	protein	protein	NOUN
afs-72863	198	21	and	and	CCONJ
afs-72863	198	22	internal	internal	ADJ
afs-72863	198	23	tryptic	tryptic	ADJ
afs-72863	198	24	peptides	peptide	NOUN
afs-72863	198	25	(	(	PUNCT
afs-72863	198	26	vidgrén	vidgrén	VERB
afs-72863	198	27	et	et	PROPN
afs-72863	198	28	al	al	PROPN
afs-72863	198	29	.	.	PROPN
afs-72863	198	30	1992	1992	NUM
afs-72863	198	31	)	)	PUNCT
afs-72863	198	32	.	.	PUNCT
afs-72863	199	1	the	the	DET
afs-72863	199	2	l.	l.	PROPN
afs-72863	199	3	brevis	brevis	PROPN
afs-72863	199	4	slpa	slpa	PROPN
afs-72863	199	5	gene	gene	NOUN
afs-72863	199	6	is	be	AUX
afs-72863	199	7	1395	1395	NUM
afs-72863	199	8	bp	bp	NOUN
afs-72863	199	9	in	in	ADP
afs-72863	199	10	size	size	NOUN
afs-72863	199	11	with	with	ADP
afs-72863	199	12	a	a	DET
afs-72863	199	13	coding	code	VERB
afs-72863	199	14	capacity	capacity	NOUN
afs-72863	199	15	for	for	ADP
afs-72863	199	16	a	a	DET
afs-72863	199	17	protein	protein	NOUN
afs-72863	199	18	of	of	ADP
afs-72863	199	19	48	48	NUM
afs-72863	199	20	159	159	NUM
afs-72863	199	21	daltons	dalton	NOUN
afs-72863	199	22	.	.	PUNCT
afs-72863	200	1	the	the	DET
afs-72863	200	2	first	first	ADJ
afs-72863	200	3	90	90	NUM
afs-72863	200	4	nucleotides	nucleotide	NOUN
afs-72863	200	5	of	of	ADP
afs-72863	200	6	the	the	DET
afs-72863	200	7	structural	structural	ADJ
afs-72863	200	8	gene	gene	NOUN
afs-72863	200	9	encode	encode	VERB
afs-72863	200	10	a	a	DET
afs-72863	200	11	typical	typical	ADJ
afs-72863	200	12	gram	gram	NOUN
afs-72863	200	13	-	-	PUNCT
afs-72863	200	14	positive	positive	ADJ
afs-72863	200	15	type	type	NOUN
afs-72863	200	16	signal	signal	NOUN
afs-72863	200	17	peptide	peptide	NOUN
afs-72863	200	18	of	of	ADP
afs-72863	200	19	30	30	NUM
afs-72863	200	20	amino	amino	NOUN
afs-72863	200	21	acid	acid	NOUN
afs-72863	200	22	residues	residue	NOUN
afs-72863	200	23	(	(	PUNCT
afs-72863	200	24	vidgrén	vidgrén	VERB
afs-72863	200	25	et	et	PROPN
afs-72863	200	26	al	al	PROPN
afs-72863	200	27	.	.	PROPN
afs-72863	200	28	1992	1992	NUM
afs-72863	200	29	)	)	PUNCT
afs-72863	200	30	.	.	PUNCT
afs-72863	201	1	the	the	DET
afs-72863	201	2	slpa	slpa	ADJ
afs-72863	201	3	gene	gene	NOUN
afs-72863	201	4	is	be	AUX
afs-72863	201	5	preceded	precede	VERB
afs-72863	201	6	by	by	ADP
afs-72863	201	7	a	a	DET
afs-72863	201	8	well	well	ADV
afs-72863	201	9	conserved	conserve	VERB
afs-72863	201	10	ribosome	ribosome	ADJ
afs-72863	201	11	binding	bind	VERB
afs-72863	201	12	site	site	NOUN
afs-72863	201	13	(	(	PUNCT
afs-72863	201	14	rbs	rbs	PROPN
afs-72863	201	15	)	)	PUNCT
afs-72863	201	16	and	and	CCONJ
afs-72863	201	17	two	two	NUM
afs-72863	201	18	promoter	promoter	NOUN
afs-72863	201	19	regions	region	NOUN
afs-72863	201	20	,	,	PUNCT
afs-72863	201	21	pi	pi	NOUN
afs-72863	201	22	and	and	CCONJ
afs-72863	201	23	p	p	NOUN
afs-72863	201	24	2	2	NUM
afs-72863	201	25	with	with	ADP
afs-72863	201	26	the	the	DET
afs-72863	201	27	-35	-35	NUM
afs-72863	201	28	and	and	CCONJ
afs-72863	201	29	-10	-10	PUNCT
afs-72863	201	30	regions	region	NOUN
afs-72863	201	31	resembling	resemble	VERB
afs-72863	201	32	the	the	DET
afs-72863	201	33	conserved	conserved	ADJ
afs-72863	201	34	prokaryotic	prokaryotic	ADJ
afs-72863	201	35	-35	-35	PUNCT
afs-72863	201	36	and	and	CCONJ
afs-72863	201	37	-10	-10	PUNCT
afs-72863	201	38	consensus	consensus	NOUN
afs-72863	201	39	sequences	sequence	NOUN
afs-72863	201	40	(	(	PUNCT
afs-72863	201	41	von	von	PROPN
afs-72863	201	42	heijne	heijne	PROPN
afs-72863	201	43	1987	1987	NUM
afs-72863	201	44	)	)	PUNCT
afs-72863	201	45	.	.	PUNCT
afs-72863	202	1	a	a	DET
afs-72863	202	2	strong	strong	ADJ
afs-72863	202	3	transcription	transcription	NOUN
afs-72863	202	4	terminator	terminator	NOUN
afs-72863	202	5	sequence	sequence	NOUN
afs-72863	202	6	is	be	AUX
afs-72863	202	7	present	present	ADJ
afs-72863	202	8	downstream	downstream	NOUN
afs-72863	202	9	of	of	ADP
afs-72863	202	10	the	the	DET
afs-72863	202	11	two	two	NUM
afs-72863	202	12	translation	translation	NOUN
afs-72863	202	13	stop	stop	VERB
afs-72863	202	14	codons	codon	NOUN
afs-72863	202	15	of	of	ADP
afs-72863	202	16	slpa	slpa	NOUN
afs-72863	202	17	.	.	PUNCT
afs-72863	203	1	at	at	ADP
afs-72863	203	2	the	the	DET
afs-72863	203	3	time	time	NOUN
afs-72863	203	4	the	the	DET
afs-72863	203	5	basic	basic	ADJ
afs-72863	203	6	characterisation	characterisation	NOUN
afs-72863	203	7	of	of	ADP
afs-72863	203	8	the	the	DET
afs-72863	203	9	l.	l.	PROPN
afs-72863	203	10	brevis	brevis	PROPN
afs-72863	203	11	s	s	NOUN
afs-72863	203	12	-	-	NOUN
afs-72863	203	13	protein	protein	NOUN
afs-72863	203	14	and	and	CCONJ
afs-72863	203	15	slpa	slpa	NOUN
afs-72863	203	16	was	be	AUX
afs-72863	203	17	published	publish	VERB
afs-72863	203	18	,	,	PUNCT
afs-72863	203	19	data	datum	NOUN
afs-72863	203	20	bases	basis	NOUN
afs-72863	203	21	contained	contain	VERB
afs-72863	203	22	no	no	DET
afs-72863	203	23	genuinely	genuinely	ADV
afs-72863	203	24	related	relate	VERB
afs-72863	203	25	slpa	slpa	ADJ
afs-72863	203	26	sequences	sequence	NOUN
afs-72863	203	27	(	(	PUNCT
afs-72863	203	28	vidgrén	vidgrén	VERB
afs-72863	203	29	et	et	PROPN
afs-72863	203	30	al	al	PROPN
afs-72863	203	31	.	.	PROPN
afs-72863	203	32	1992	1992	NUM
afs-72863	203	33	)	)	PUNCT
afs-72863	203	34	.	.	PUNCT
afs-72863	204	1	the	the	DET
afs-72863	204	2	predicted	predict	VERB
afs-72863	204	3	amino	amino	NOUN
afs-72863	204	4	acid	acid	NOUN
afs-72863	204	5	sequences	sequence	NOUN
afs-72863	204	6	of	of	ADP
afs-72863	204	7	the	the	DET
afs-72863	204	8	recently	recently	ADV
afs-72863	204	9	described	describe	VERB
afs-72863	204	10	l.	l.	PROPN
afs-72863	204	11	acidophilus	acidophilus	PROPN
afs-72863	204	12	(	(	PUNCT
afs-72863	204	13	boot	boot	NOUN
afs-72863	204	14	et	et	PROPN
afs-72863	204	15	al	al	PROPN
afs-72863	204	16	.	.	PROPN
afs-72863	204	17	1993	1993	NUM
afs-72863	204	18	)	)	PUNCT
afs-72863	204	19	and	and	CCONJ
afs-72863	204	20	l.	l.	PROPN
afs-72863	204	21	helvetians	helvetians	PROPN
afs-72863	204	22	(	(	PUNCT
afs-72863	204	23	embl	embl	PROPN
afs-72863	204	24	nucleotide	nucleotide	PROPN
afs-72863	204	25	data	data	PROPN
afs-72863	204	26	library	library	NOUN
afs-72863	204	27	:	:	PUNCT
afs-72863	204	28	x91199	x91199	NUM
afs-72863	204	29	and	and	CCONJ
afs-72863	204	30	x92752	x92752	NOUN
afs-72863	204	31	)	)	PUNCT
afs-72863	204	32	slpa	slpa	ADJ
afs-72863	204	33	genes	gene	NOUN
afs-72863	204	34	,	,	PUNCT
afs-72863	204	35	however	however	ADV
afs-72863	204	36	,	,	PUNCT
afs-72863	204	37	show	show	VERB
afs-72863	204	38	35.7	35.7	NUM
afs-72863	204	39	%	%	NOUN
afs-72863	204	40	(	(	PUNCT
afs-72863	204	41	17	17	NUM
afs-72863	204	42	)	)	PUNCT
afs-72863	204	43	and	and	CCONJ
afs-72863	204	44	28.8	28.8	NUM
afs-72863	204	45	%	%	NOUN
afs-72863	204	46	similarity	similarity	NOUN
afs-72863	204	47	to	to	ADP
afs-72863	204	48	that	that	PRON
afs-72863	204	49	of	of	ADP
afs-72863	204	50	the	the	DET
afs-72863	204	51	l.	l.	PROPN
afs-72863	204	52	brevis	brevis	PROPN
afs-72863	204	53	s	s	PROPN
afs-72863	204	54	-	-	NOUN
afs-72863	204	55	protein	protein	NOUN
afs-72863	204	56	,	,	PUNCT
afs-72863	204	57	respectively	respectively	ADV
afs-72863	204	58	.	.	PUNCT
afs-72863	205	1	furthermore	furthermore	ADV
afs-72863	205	2	,	,	PUNCT
afs-72863	205	3	l.	l.	PROPN
afs-72863	205	4	brevis	brevis	PROPN
afs-72863	205	5	slpa	slpa	ADJ
afs-72863	205	6	probes	probe	NOUN
afs-72863	205	7	hybridises	hybridise	NOUN
afs-72863	205	8	to	to	ADP
afs-72863	205	9	the	the	DET
afs-72863	205	10	chromosomaldna	chromosomaldna	PROPN
afs-72863	205	11	ofl	ofl	PROPN
afs-72863	205	12	.	.	PROPN
afs-72863	205	13	buchneri	buchneri	PROPN
afs-72863	205	14	(	(	PUNCT
afs-72863	205	15	palva	palva	PROPN
afs-72863	205	16	et	et	PROPN
afs-72863	205	17	al	al	PROPN
afs-72863	205	18	.	.	PROPN
afs-72863	206	1	1992).two	1992).two	NUM
afs-72863	206	2	sip	sip	NOUN
afs-72863	206	3	genes	gene	NOUN
afs-72863	206	4	with	with	ADP
afs-72863	206	5	phase	phase	NOUN
afs-72863	206	6	variation	variation	NOUN
afs-72863	206	7	have	have	AUX
afs-72863	206	8	been	be	AUX
afs-72863	206	9	found	find	VERB
afs-72863	206	10	in	in	ADP
afs-72863	206	11	l.	l.	PROPN
afs-72863	206	12	acidophilus	acidophilus	PROPN
afs-72863	206	13	,	,	PUNCT
afs-72863	206	14	and	and	CCONJ
afs-72863	206	15	one	one	NUM
afs-72863	206	16	functional	functional	ADJ
afs-72863	206	17	sip	sip	NOUN
afs-72863	206	18	gene	gene	NOUN
afs-72863	206	19	and	and	CCONJ
afs-72863	206	20	a	a	DET
afs-72863	206	21	truncated	truncated	ADJ
afs-72863	206	22	sip	sip	NOUN
afs-72863	206	23	3’end	3’end	NUM
afs-72863	206	24	in	in	ADP
afs-72863	206	25	l.	l.	PROPN
afs-72863	206	26	helveticus	helveticus	PROPN
afs-72863	206	27	(	(	PUNCT
afs-72863	206	28	boot	boot	NOUN
afs-72863	206	29	1996	1996	NUM
afs-72863	206	30	)	)	PUNCT
afs-72863	206	31	.	.	PUNCT
afs-72863	207	1	in	in	ADP
afs-72863	207	2	l.	l.	PROPN
afs-72863	207	3	brevis	brevis	PROPN
afs-72863	207	4	,	,	PUNCT
afs-72863	207	5	in	in	ADP
afs-72863	207	6	contrast	contrast	NOUN
afs-72863	207	7	only	only	ADV
afs-72863	207	8	one	one	NUM
afs-72863	207	9	sip	sip	NOUN
afs-72863	207	10	gene	gene	NOUN
afs-72863	207	11	is	be	AUX
afs-72863	207	12	present	present	ADJ
afs-72863	207	13	(	(	PUNCT
afs-72863	207	14	palva	palva	NOUN
afs-72863	207	15	et	et	PROPN
afs-72863	207	16	al	al	PROPN
afs-72863	207	17	.	.	PROPN
afs-72863	207	18	1992	1992	NUM
afs-72863	207	19	)	)	PUNCT
afs-72863	207	20	.	.	PUNCT
afs-72863	208	1	in	in	ADP
afs-72863	208	2	vivo	vivo	ADJ
afs-72863	208	3	expression	expression	NOUN
afs-72863	208	4	of	of	ADP
afs-72863	208	5	the	the	DET
afs-72863	208	6	slpa	slpa	ADJ
afs-72863	208	7	gene	gene	NOUN
afs-72863	208	8	determination	determination	NOUN
afs-72863	208	9	of	of	ADP
afs-72863	208	10	the	the	DET
afs-72863	208	11	size	size	NOUN
afs-72863	208	12	and	and	CCONJ
afs-72863	208	13	s’ends	s’end	NOUN
afs-72863	208	14	of	of	ADP
afs-72863	208	15	the	the	DET
afs-72863	208	16	slpa	slpa	ADJ
afs-72863	208	17	transcripts	transcript	NOUN
afs-72863	208	18	revealed	reveal	VERB
afs-72863	208	19	1.5	1.5	NUM
afs-72863	208	20	kb	kb	PROPN
afs-72863	208	21	mrnas	mrna	NOUN
afs-72863	208	22	with	with	ADP
afs-72863	208	23	two	two	NUM
afs-72863	208	24	5	5	NUM
afs-72863	208	25	’	'	PUNCT
afs-72863	208	26	ends	end	NOUN
afs-72863	208	27	located	locate	VERB
afs-72863	208	28	immediately	immediately	ADV
afs-72863	208	29	downstreamof	downstreamof	VERB
afs-72863	208	30	the	the	DET
afs-72863	208	31	two	two	NUM
afs-72863	208	32	-10	-10	NOUN
afs-72863	208	33	regions	region	NOUN
afs-72863	208	34	deduced	deduce	VERB
afs-72863	208	35	from	from	ADP
afs-72863	208	36	the	the	DET
afs-72863	208	37	dna	dna	PROPN
afs-72863	208	38	sequence	sequence	NOUN
afs-72863	208	39	,	,	PUNCT
afs-72863	208	40	thus	thus	ADV
afs-72863	208	41	confirming	confirm	VERB
afs-72863	208	42	that	that	DET
afs-72863	208	43	slpa	slpa	NOUN
afs-72863	208	44	is	be	AUX
afs-72863	208	45	a	a	DET
afs-72863	208	46	monocistronic	monocistronic	ADJ
afs-72863	208	47	transcriptional	transcriptional	NOUN
afs-72863	208	48	unit	unit	NOUN
afs-72863	208	49	and	and	CCONJ
afs-72863	208	50	possesses	possess	VERB
afs-72863	208	51	two	two	NUM
afs-72863	208	52	functional	functional	ADJ
afs-72863	208	53	promoters	promoter	NOUN
afs-72863	208	54	(	(	PUNCT
afs-72863	208	55	pi	pi	NOUN
afs-72863	208	56	,	,	PUNCT
afs-72863	208	57	p2	p2	PROPN
afs-72863	208	58	)	)	PUNCT
afs-72863	208	59	(	(	PUNCT
afs-72863	208	60	vidgrén	vidgrén	VERB
afs-72863	208	61	et	et	PROPN
afs-72863	208	62	al	al	PROPN
afs-72863	208	63	.	.	PROPN
afs-72863	208	64	1992	1992	NUM
afs-72863	208	65	)	)	PUNCT
afs-72863	208	66	.	.	PUNCT
afs-72863	209	1	determination	determination	NOUN
afs-72863	209	2	of	of	ADP
afs-72863	209	3	the	the	DET
afs-72863	209	4	stability	stability	NOUN
afs-72863	209	5	of	of	ADP
afs-72863	209	6	the	the	DET
afs-72863	209	7	slpa	slpa	ADJ
afs-72863	209	8	mrna	mrna	PROPN
afs-72863	209	9	showed	show	VERB
afs-72863	209	10	that	that	SCONJ
afs-72863	209	11	the	the	DET
afs-72863	209	12	halflife	halflife	NOUN
afs-72863	209	13	of	of	ADP
afs-72863	209	14	the	the	DET
afs-72863	209	15	slpa	slpa	ADJ
afs-72863	209	16	transcripts	transcript	NOUN
afs-72863	209	17	was	be	AUX
afs-72863	209	18	14	14	NUM
afs-72863	209	19	minutes	minute	NOUN
afs-72863	209	20	(	(	PUNCT
afs-72863	209	21	kahala	kahala	PROPN
afs-72863	209	22	et	et	PROPN
afs-72863	209	23	al	al	PROPN
afs-72863	209	24	.	.	PROPN
afs-72863	209	25	1997	1997	NUM
afs-72863	209	26	)	)	PUNCT
afs-72863	209	27	,	,	PUNCT
afs-72863	209	28	indicating	indicate	VERB
afs-72863	209	29	exceptional	exceptional	ADJ
afs-72863	209	30	stability	stability	NOUN
afs-72863	209	31	when	when	SCONJ
afs-72863	209	32	compared	compare	VERB
afs-72863	209	33	with	with	ADP
afs-72863	209	34	the	the	DET
afs-72863	209	35	typical	typical	ADJ
afs-72863	209	36	half	half	ADJ
afs-72863	209	37	-	-	PUNCT
afs-72863	209	38	lives	life	NOUN
afs-72863	209	39	of	of	ADP
afs-72863	209	40	prokaryotic	prokaryotic	ADJ
afs-72863	209	41	mrnas	mrna	NOUN
afs-72863	209	42	.	.	PUNCT
afs-72863	210	1	recently	recently	ADV
afs-72863	210	2	,	,	PUNCT
afs-72863	210	3	the	the	DET
afs-72863	210	4	half	half	ADJ
afs-72863	210	5	-	-	PUNCT
afs-72863	210	6	lives	life	NOUN
afs-72863	210	7	of	of	ADP
afs-72863	210	8	the	the	DET
afs-72863	210	9	l.	l.	PROPN
afs-72863	210	10	acidophilus	acidophilus	PROPN
afs-72863	210	11	slpa	slpa	NOUN
afs-72863	210	12	and	and	CCONJ
afs-72863	210	13	aeromonas	aeromonas	PROPN
afs-72863	210	14	salmonicida	salmonicida	PROPN
afs-72863	210	15	vapa	vapa	VERB
afs-72863	210	16	mrnas	mrna	NOUN
afs-72863	210	17	have	have	AUX
afs-72863	210	18	also	also	ADV
afs-72863	210	19	been	be	AUX
afs-72863	210	20	shown	show	VERB
afs-72863	210	21	to	to	PART
afs-72863	210	22	be	be	AUX
afs-72863	210	23	very	very	ADV
afs-72863	210	24	stable	stable	ADJ
afs-72863	210	25	(	(	PUNCT
afs-72863	210	26	boot	boot	NOUN
afs-72863	210	27	et	et	PROPN
afs-72863	210	28	al	al	PROPN
afs-72863	210	29	.	.	PROPN
afs-72863	210	30	1996	1996	NUM
afs-72863	210	31	,	,	PUNCT
afs-72863	210	32	chu	chu	PROPN
afs-72863	210	33	et	et	PROPN
afs-72863	210	34	al	al	PROPN
afs-72863	210	35	.	.	PROPN
afs-72863	210	36	1993	1993	NUM
afs-72863	210	37	)	)	PUNCT
afs-72863	210	38	.	.	PUNCT
afs-72863	211	1	the	the	DET
afs-72863	211	2	long	long	ADJ
afs-72863	211	3	half	half	ADJ
afs-72863	211	4	-	-	PUNCT
afs-72863	211	5	lives	life	NOUN
afs-72863	211	6	of	of	ADP
afs-72863	211	7	these	these	DET
afs-72863	211	8	three	three	NUM
afs-72863	211	9	s	s	NOUN
afs-72863	211	10	-	-	PUNCT
afs-72863	211	11	layer	layer	NOUN
afs-72863	211	12	mrnas	mrna	NOUN
afs-72863	211	13	from	from	ADP
afs-72863	211	14	three	three	NUM
afs-72863	211	15	different	different	ADJ
afs-72863	211	16	species	specie	NOUN
afs-72863	211	17	may	may	AUX
afs-72863	211	18	indicate	indicate	VERB
afs-72863	211	19	that	that	SCONJ
afs-72863	211	20	a	a	DET
afs-72863	211	21	high	high	ADJ
afs-72863	211	22	stability	stability	NOUN
afs-72863	211	23	of	of	ADP
afs-72863	211	24	mrna	mrna	PROPN
afs-72863	211	25	is	be	AUX
afs-72863	211	26	a	a	DET
afs-72863	211	27	general	general	ADJ
afs-72863	211	28	feature	feature	NOUN
afs-72863	211	29	of	of	ADP
afs-72863	211	30	s	s	NOUN
afs-72863	211	31	-	-	PUNCT
afs-72863	211	32	layer	layer	NOUN
afs-72863	211	33	mrnas	mrna	NOUN
afs-72863	211	34	.	.	PUNCT
afs-72863	212	1	as	as	ADP
afs-72863	212	2	slpa	slpa	ADJ
afs-72863	212	3	275	275	NUM
afs-72863	212	4	voi	voi	NOUN
afs-72863	212	5	7	7	NUM
afs-72863	212	6	(	(	PUNCT
afs-72863	212	7	1998	1998	NUM
afs-72863	212	8	):	):	PUNCT
afs-72863	212	9	267	267	NUM
afs-72863	212	10	-	-	SYM
afs-72863	212	11	282	282	NUM
afs-72863	212	12	.	.	PUNCT
afs-72863	212	13	agricultural	agricultural	ADJ
afs-72863	212	14	and	and	CCONJ
afs-72863	212	15	food	food	NOUN
afs-72863	212	16	science	science	NOUN
afs-72863	212	17	in	in	ADP
afs-72863	212	18	finland	finland	PROPN
afs-72863	212	19	mrna	mrna	PROPN
afs-72863	212	20	mediates	mediate	VERB
afs-72863	212	21	the	the	DET
afs-72863	212	22	synthesis	synthesis	NOUN
afs-72863	212	23	of	of	ADP
afs-72863	212	24	a	a	DET
afs-72863	212	25	major	major	ADJ
afs-72863	212	26	structural	structural	ADJ
afs-72863	212	27	component	component	NOUN
afs-72863	212	28	of	of	ADP
afs-72863	212	29	the	the	DET
afs-72863	212	30	cell	cell	NOUN
afs-72863	212	31	,	,	PUNCT
afs-72863	212	32	this	this	DET
afs-72863	212	33	high	high	ADJ
afs-72863	212	34	stability	stability	NOUN
afs-72863	212	35	is	be	AUX
afs-72863	212	36	not	not	PART
afs-72863	212	37	unexpected	unexpected	ADJ
afs-72863	212	38	.	.	PUNCT
afs-72863	213	1	study	study	NOUN
afs-72863	213	2	of	of	ADP
afs-72863	213	3	the	the	DET
afs-72863	213	4	usage	usage	NOUN
afs-72863	213	5	of	of	ADP
afs-72863	213	6	the	the	DET
afs-72863	213	7	two	two	NUM
afs-72863	213	8	l.	l.	PROPN
afs-72863	213	9	brevis	brevis	PROPN
afs-72863	213	10	slpa	slpa	PROPN
afs-72863	213	11	promoters	promoter	NOUN
afs-72863	213	12	(	(	PUNCT
afs-72863	213	13	pi	pi	NOUN
afs-72863	213	14	,	,	PUNCT
afs-72863	213	15	p2	p2	PROPN
afs-72863	213	16	)	)	PUNCT
afs-72863	213	17	at	at	ADP
afs-72863	213	18	different	different	ADJ
afs-72863	213	19	stages	stage	NOUN
afs-72863	213	20	of	of	ADP
afs-72863	213	21	the	the	DET
afs-72863	213	22	growthrevealed	growthreveale	VERB
afs-72863	213	23	that	that	DET
afs-72863	213	24	thep	thep	NOUN
afs-72863	213	25	2	2	NUM
afs-72863	213	26	promoter	promoter	NOUN
afs-72863	213	27	,	,	PUNCT
afs-72863	213	28	which	which	PRON
afs-72863	213	29	was	be	AUX
afs-72863	213	30	located	locate	VERB
afs-72863	213	31	closer	close	ADV
afs-72863	213	32	to	to	ADP
afs-72863	213	33	the	the	DET
afs-72863	213	34	start	start	NOUN
afs-72863	213	35	codon	codon	NOUN
afs-72863	213	36	,	,	PUNCT
afs-72863	213	37	is	be	AUX
afs-72863	213	38	efficiently	efficiently	ADV
afs-72863	213	39	used	use	VERB
afs-72863	213	40	during	during	ADP
afs-72863	213	41	both	both	CCONJ
afs-72863	213	42	the	the	DET
afs-72863	213	43	logarithmic	logarithmic	ADJ
afs-72863	213	44	and	and	CCONJ
afs-72863	213	45	early	early	ADJ
afs-72863	213	46	stationary	stationary	ADJ
afs-72863	213	47	phases	phase	NOUN
afs-72863	213	48	,	,	PUNCT
afs-72863	213	49	whereas	whereas	SCONJ
afs-72863	213	50	slpa	slpa	PROPN
afs-72863	213	51	mrna	mrna	PROPN
afs-72863	213	52	derived	derive	VERB
afs-72863	213	53	from	from	ADP
afs-72863	213	54	pi	pi	NOUN
afs-72863	213	55	was	be	AUX
afs-72863	213	56	only	only	ADV
afs-72863	213	57	weakly	weakly	ADV
afs-72863	213	58	detectable	detectable	ADJ
afs-72863	213	59	(	(	PUNCT
afs-72863	213	60	kahala	kahala	PROPN
afs-72863	213	61	et	et	PROPN
afs-72863	213	62	al	al	PROPN
afs-72863	213	63	.	.	PROPN
afs-72863	213	64	1997	1997	NUM
afs-72863	213	65	)	)	PUNCT
afs-72863	213	66	.	.	PUNCT
afs-72863	214	1	further	far	ADV
afs-72863	214	2	quantitative	quantitative	ADJ
afs-72863	214	3	analyses	analysis	NOUN
afs-72863	214	4	showed	show	VERB
afs-72863	214	5	that	that	SCONJ
afs-72863	214	6	transcripts	transcript	NOUN
afs-72863	214	7	derived	derive	VERB
afs-72863	214	8	from	from	ADP
afs-72863	214	9	both	both	DET
afs-72863	214	10	promoters	promoter	NOUN
afs-72863	214	11	are	be	AUX
afs-72863	214	12	present	present	ADJ
afs-72863	214	13	throughout	throughout	ADP
afs-72863	214	14	the	the	DET
afs-72863	214	15	entire	entire	ADJ
afs-72863	214	16	growth	growth	NOUN
afs-72863	214	17	phase	phase	NOUN
afs-72863	214	18	and	and	CCONJ
afs-72863	214	19	that	that	SCONJ
afs-72863	214	20	the	the	DET
afs-72863	214	21	level	level	NOUN
afs-72863	214	22	oftranscripts	oftranscript	NOUN
afs-72863	214	23	derived	derive	VERB
afs-72863	214	24	from	from	ADP
afs-72863	214	25	promoter	promoter	NOUN
afs-72863	214	26	p	p	PROPN
afs-72863	214	27	2	2	NUM
afs-72863	214	28	is	be	AUX
afs-72863	214	29	ten	ten	NUM
afs-72863	214	30	times	time	NOUN
afs-72863	214	31	higher	high	ADJ
afs-72863	214	32	than	than	ADP
afs-72863	214	33	that	that	PRON
afs-72863	214	34	derived	derive	VERB
afs-72863	214	35	from	from	ADP
afs-72863	214	36	pi	pi	PROPN
afs-72863	214	37	(	(	PUNCT
afs-72863	214	38	kahala	kahala	PROPN
afs-72863	214	39	et	et	PROPN
afs-72863	214	40	al	al	PROPN
afs-72863	214	41	.	.	PROPN
afs-72863	214	42	1997	1997	NUM
afs-72863	214	43	)	)	PUNCT
afs-72863	214	44	.	.	PUNCT
afs-72863	215	1	s	s	X
afs-72863	215	2	-	-	PUNCT
afs-72863	215	3	layer	layer	NOUN
afs-72863	215	4	synthesis	synthesis	NOUN
afs-72863	215	5	in	in	ADP
afs-72863	215	6	vivo	vivo	ADJ
afs-72863	215	7	expression	expression	NOUN
afs-72863	215	8	studies	study	NOUN
afs-72863	215	9	of	of	ADP
afs-72863	215	10	l.	l.	PROPN
afs-72863	215	11	brevis	brevis	PROPN
afs-72863	215	12	showed	show	VERB
afs-72863	215	13	that	that	SCONJ
afs-72863	215	14	the	the	DET
afs-72863	215	15	kinetics	kinetic	NOUN
afs-72863	215	16	of	of	ADP
afs-72863	215	17	the	the	DET
afs-72863	215	18	accumulations	accumulation	NOUN
afs-72863	215	19	of	of	ADP
afs-72863	215	20	slpa	slpa	ADJ
afs-72863	215	21	mrna	mrna	NOUN
afs-72863	215	22	and	and	CCONJ
afs-72863	215	23	protein	protein	NOUN
afs-72863	215	24	correlates	correlate	VERB
afs-72863	215	25	well	well	ADV
afs-72863	215	26	up	up	ADP
afs-72863	215	27	to	to	ADP
afs-72863	215	28	the	the	DET
afs-72863	215	29	onset	onset	NOUN
afs-72863	215	30	of	of	ADP
afs-72863	215	31	the	the	DET
afs-72863	215	32	stationary	stationary	ADJ
afs-72863	215	33	phase	phase	NOUN
afs-72863	215	34	,	,	PUNCT
afs-72863	215	35	when	when	SCONJ
afs-72863	215	36	there	there	PRON
afs-72863	215	37	is	be	VERB
afs-72863	215	38	a	a	DET
afs-72863	215	39	sharp	sharp	ADJ
afs-72863	215	40	decrease	decrease	NOUN
afs-72863	215	41	in	in	ADP
afs-72863	215	42	the	the	DET
afs-72863	215	43	level	level	NOUN
afs-72863	215	44	of	of	ADP
afs-72863	215	45	slpa	slpa	ADJ
afs-72863	215	46	mrna	mrna	PROPN
afs-72863	215	47	.	.	PUNCT
afs-72863	216	1	the	the	DET
afs-72863	216	2	rate	rate	NOUN
afs-72863	216	3	of	of	ADP
afs-72863	216	4	mrna	mrna	PROPN
afs-72863	216	5	decay	decay	NOUN
afs-72863	216	6	was	be	AUX
afs-72863	216	7	,	,	PUNCT
afs-72863	216	8	however	however	ADV
afs-72863	216	9	,	,	PUNCT
afs-72863	216	10	slower	slow	ADJ
afs-72863	216	11	than	than	SCONJ
afs-72863	216	12	expected	expect	VERB
afs-72863	216	13	from	from	ADP
afs-72863	216	14	the	the	DET
afs-72863	216	15	half	half	ADJ
afs-72863	216	16	-	-	PUNCT
afs-72863	216	17	life	life	NOUN
afs-72863	216	18	of	of	ADP
afs-72863	216	19	slpa	slpa	ADJ
afs-72863	216	20	transcripts	transcript	NOUN
afs-72863	216	21	,	,	PUNCT
afs-72863	216	22	suggesting	suggest	VERB
afs-72863	216	23	that	that	SCONJ
afs-72863	216	24	residual	residual	ADJ
afs-72863	216	25	transcription	transcription	NOUN
afs-72863	216	26	continues	continue	VERB
afs-72863	216	27	even	even	ADV
afs-72863	216	28	though	though	SCONJ
afs-72863	216	29	the	the	DET
afs-72863	216	30	total	total	ADJ
afs-72863	216	31	amount	amount	NOUN
afs-72863	216	32	of	of	ADP
afs-72863	216	33	s	s	NOUN
afs-72863	216	34	-	-	NOUN
afs-72863	216	35	protein	protein	NOUN
afs-72863	216	36	does	do	AUX
afs-72863	216	37	not	not	PART
afs-72863	216	38	further	far	ADV
afs-72863	216	39	increase	increase	VERB
afs-72863	216	40	at	at	ADP
afs-72863	216	41	the	the	DET
afs-72863	216	42	stationary	stationary	ADJ
afs-72863	216	43	phase	phase	NOUN
afs-72863	216	44	(	(	PUNCT
afs-72863	216	45	kahala	kahala	PROPN
afs-72863	216	46	et	et	PROPN
afs-72863	216	47	al	al	PROPN
afs-72863	216	48	.	.	PROPN
afs-72863	216	49	1997	1997	NUM
afs-72863	216	50	)	)	PUNCT
afs-72863	216	51	.	.	PUNCT
afs-72863	217	1	the	the	DET
afs-72863	217	2	l.	l.	PROPN
afs-72863	217	3	brevis	brevis	PROPN
afs-72863	217	4	slayer	slayer	NOUN
afs-72863	217	5	protein	protein	NOUN
afs-72863	217	6	is	be	AUX
afs-72863	217	7	not	not	PART
afs-72863	217	8	released	release	VERB
afs-72863	217	9	into	into	ADP
afs-72863	217	10	the	the	DET
afs-72863	217	11	supernatant	supernatant	NOUN
afs-72863	217	12	fractions	fraction	NOUN
afs-72863	217	13	at	at	ADP
afs-72863	217	14	any	any	PRON
afs-72863	217	15	of	of	ADP
afs-72863	217	16	the	the	DET
afs-72863	217	17	growth	growth	NOUN
afs-72863	217	18	phases	phase	NOUN
afs-72863	217	19	studied	study	VERB
afs-72863	217	20	,	,	PUNCT
afs-72863	217	21	suggesting	suggest	VERB
afs-72863	217	22	tight	tight	ADJ
afs-72863	217	23	regulation	regulation	NOUN
afs-72863	217	24	of	of	ADP
afs-72863	217	25	the	the	DET
afs-72863	217	26	s	s	NOUN
afs-72863	217	27	-	-	PUNCT
afs-72863	217	28	layer	layer	NOUN
afs-72863	217	29	synthesis	synthesis	NOUN
afs-72863	217	30	and	and	CCONJ
afs-72863	217	31	assembly	assembly	NOUN
afs-72863	217	32	(	(	PUNCT
afs-72863	217	33	vidgrén	vidgrén	VERB
afs-72863	217	34	et	et	PROPN
afs-72863	217	35	al	al	PROPN
afs-72863	217	36	.	.	PROPN
afs-72863	217	37	1992	1992	NUM
afs-72863	217	38	,	,	PUNCT
afs-72863	217	39	kahala	kahala	PROPN
afs-72863	217	40	et	et	PROPN
afs-72863	217	41	al	al	PROPN
afs-72863	217	42	.	.	PROPN
afs-72863	217	43	1997	1997	NUM
afs-72863	217	44	)	)	PUNCT
afs-72863	217	45	.	.	PUNCT
afs-72863	218	1	breitwieser	breitwieser	NOUN
afs-72863	218	2	et	et	PROPN
afs-72863	218	3	al	al	PROPN
afs-72863	218	4	.	.	PROPN
afs-72863	219	1	(	(	PUNCT
afs-72863	219	2	1992	1992	NUM
afs-72863	219	3	)	)	PUNCT
afs-72863	219	4	demonstrated	demonstrate	VERB
afs-72863	219	5	the	the	DET
afs-72863	219	6	presence	presence	NOUN
afs-72863	219	7	of	of	ADP
afs-72863	219	8	substantial	substantial	ADJ
afs-72863	219	9	amounts	amount	NOUN
afs-72863	219	10	of	of	ADP
afs-72863	219	11	s	s	NOUN
afs-72863	219	12	-	-	PUNCT
afs-72863	219	13	layer	layer	NOUN
afs-72863	219	14	subunits	subunit	NOUN
afs-72863	219	15	on	on	ADP
afs-72863	219	16	the	the	DET
afs-72863	219	17	inner	inner	ADJ
afs-72863	219	18	surface	surface	NOUN
afs-72863	219	19	or	or	CCONJ
afs-72863	219	20	within	within	ADP
afs-72863	219	21	the	the	DET
afs-72863	219	22	peptidoglycan	peptidoglycan	ADJ
afs-72863	219	23	layer	layer	NOUN
afs-72863	219	24	of	of	ADP
afs-72863	219	25	bacillus	bacillus	NOUN
afs-72863	219	26	stearothermophilus	stearothermophilus	NOUN
afs-72863	219	27	,	,	PUNCT
afs-72863	219	28	suggesting	suggest	VERB
afs-72863	219	29	an	an	DET
afs-72863	219	30	intermediate	intermediate	ADJ
afs-72863	219	31	phase	phase	NOUN
afs-72863	219	32	between	between	ADP
afs-72863	219	33	the	the	DET
afs-72863	219	34	synthesis	synthesis	NOUN
afs-72863	219	35	and	and	CCONJ
afs-72863	219	36	final	final	ADJ
afs-72863	219	37	location	location	NOUN
afs-72863	219	38	of	of	ADP
afs-72863	219	39	the	the	DET
afs-72863	219	40	s	s	NOUN
afs-72863	219	41	-	-	PUNCT
afs-72863	219	42	layer	layer	NOUN
afs-72863	219	43	protein	protein	NOUN
afs-72863	219	44	.	.	PUNCT
afs-72863	220	1	this	this	PRON
afs-72863	220	2	has	have	AUX
afs-72863	220	3	also	also	ADV
afs-72863	220	4	frequently	frequently	ADV
afs-72863	220	5	been	be	AUX
afs-72863	220	6	observed	observe	VERB
afs-72863	220	7	in	in	ADP
afs-72863	220	8	s	s	NOUN
afs-72863	220	9	-	-	PUNCT
afs-72863	220	10	layers	layer	NOUN
afs-72863	220	11	of	of	ADP
afs-72863	220	12	other	other	ADJ
afs-72863	220	13	gram	gram	NOUN
afs-72863	220	14	-	-	PUNCT
afs-72863	220	15	positive	positive	ADJ
afs-72863	220	16	eubacteria	eubacteria	NOUN
afs-72863	220	17	(	(	PUNCT
afs-72863	220	18	breitwieser	breitwieser	NOUN
afs-72863	220	19	et	et	PROPN
afs-72863	220	20	al	al	PROPN
afs-72863	220	21	.	.	PROPN
afs-72863	220	22	1992	1992	NUM
afs-72863	220	23	)	)	PUNCT
afs-72863	220	24	.	.	PUNCT
afs-72863	221	1	flowever	flowever	PROPN
afs-72863	221	2	,	,	PUNCT
afs-72863	221	3	in	in	ADP
afs-72863	221	4	l.	l.	PROPN
afs-72863	221	5	brevis	brevis	PROPN
afs-72863	221	6	over	over	ADP
afs-72863	221	7	95	95	NUM
afs-72863	221	8	%	%	NOUN
afs-72863	221	9	of	of	ADP
afs-72863	221	10	the	the	DET
afs-72863	221	11	s	s	NOUN
afs-72863	221	12	-	-	PUNCT
afs-72863	221	13	layer	layer	NOUN
afs-72863	221	14	subunits	subunit	NOUN
afs-72863	221	15	could	could	AUX
afs-72863	221	16	be	be	AUX
afs-72863	221	17	released	release	VERB
afs-72863	221	18	with	with	ADP
afs-72863	221	19	the	the	DET
afs-72863	221	20	sdspage	sdspage	NOUN
afs-72863	221	21	sample	sample	NOUN
afs-72863	221	22	buffer	buffer	NOUN
afs-72863	221	23	from	from	ADP
afs-72863	221	24	intact	intact	ADJ
afs-72863	221	25	cells	cell	NOUN
afs-72863	221	26	,	,	PUNCT
afs-72863	221	27	as	as	SCONJ
afs-72863	221	28	indicated	indicate	VERB
afs-72863	221	29	by	by	ADP
afs-72863	221	30	western	western	ADJ
afs-72863	221	31	blot	blot	NOUN
afs-72863	221	32	analyses	analysis	NOUN
afs-72863	221	33	ofintact	ofintact	ADJ
afs-72863	221	34	and	and	CCONJ
afs-72863	221	35	disrupted	disrupt	VERB
afs-72863	221	36	cells	cell	NOUN
afs-72863	221	37	(	(	PUNCT
afs-72863	221	38	unpublished	unpublished	ADJ
afs-72863	221	39	data	datum	NOUN
afs-72863	221	40	)	)	PUNCT
afs-72863	221	41	.	.	PUNCT
afs-72863	222	1	it	it	PRON
afs-72863	222	2	appears	appear	VERB
afs-72863	222	3	,	,	PUNCT
afs-72863	222	4	then	then	ADV
afs-72863	222	5	,	,	PUNCT
afs-72863	222	6	that	that	SCONJ
afs-72863	222	7	basically	basically	ADV
afs-72863	222	8	no	no	DET
afs-72863	222	9	l.	l.	NOUN
afs-72863	222	10	brevis	brevis	PROPN
afs-72863	222	11	s	s	PROPN
afs-72863	222	12	-	-	PUNCT
afs-72863	222	13	layer	layer	NOUN
afs-72863	222	14	subunits	subunit	NOUN
afs-72863	222	15	accumulated	accumulate	VERB
afs-72863	222	16	inside	inside	ADP
afs-72863	222	17	the	the	DET
afs-72863	222	18	peptidoglycan	peptidoglycan	ADJ
afs-72863	222	19	layer	layer	NOUN
afs-72863	222	20	before	before	ADP
afs-72863	222	21	translocation	translocation	NOUN
afs-72863	222	22	to	to	ADP
afs-72863	222	23	the	the	DET
afs-72863	222	24	outer	outer	ADJ
afs-72863	222	25	surface	surface	NOUN
afs-72863	222	26	.	.	PUNCT
afs-72863	223	1	heterologous	heterologous	ADJ
afs-72863	223	2	protein	protein	NOUN
afs-72863	223	3	secretion	secretion	NOUN
afs-72863	223	4	with	with	ADP
afs-72863	223	5	the	the	DET
afs-72863	223	6	sipa	sipa	NOUN
afs-72863	223	7	signals	signal	NOUN
afs-72863	223	8	to	to	PART
afs-72863	223	9	construct	construct	VERB
afs-72863	223	10	a	a	DET
afs-72863	223	11	secretion	secretion	NOUN
afs-72863	223	12	vector	vector	NOUN
afs-72863	223	13	based	base	VERB
afs-72863	223	14	on	on	ADP
afs-72863	223	15	the	the	DET
afs-72863	223	16	slpa	slpa	ADJ
afs-72863	223	17	signals	signal	NOUN
afs-72863	223	18	,	,	PUNCT
afs-72863	223	19	we	we	PRON
afs-72863	223	20	used	use	VERB
afs-72863	223	21	a	a	DET
afs-72863	223	22	derivative	derivative	ADJ
afs-72863	223	23	(	(	PUNCT
afs-72863	223	24	pkth2o9s	pkth2o9s	PROPN
afs-72863	223	25	)	)	PUNCT
afs-72863	223	26	of	of	ADP
afs-72863	223	27	the	the	DET
afs-72863	223	28	shuttle	shuttle	NOUN
afs-72863	223	29	vector	vector	NOUN
afs-72863	223	30	pgki2	pgki2	NOUN
afs-72863	223	31	(	(	PUNCT
afs-72863	223	32	kok	kok	PROPN
afs-72863	223	33	et	et	PROPN
afs-72863	223	34	al	al	PROPN
afs-72863	223	35	.	.	PROPN
afs-72863	223	36	1984	1984	NUM
afs-72863	223	37	)	)	PUNCT
afs-72863	223	38	as	as	ADP
afs-72863	223	39	the	the	DET
afs-72863	223	40	carrier	carrier	NOUN
afs-72863	223	41	of	of	ADP
afs-72863	223	42	the	the	DET
afs-72863	223	43	secretion	secretion	NOUN
afs-72863	223	44	cassette	cassette	NOUN
afs-72863	223	45	.	.	PUNCT
afs-72863	224	1	the	the	DET
afs-72863	224	2	model	model	NOUN
afs-72863	224	3	secretion	secretion	NOUN
afs-72863	224	4	cassette	cassette	NOUN
afs-72863	224	5	contained	contain	VERB
afs-72863	224	6	the	the	DET
afs-72863	224	7	two	two	NUM
afs-72863	224	8	promoters	promoter	NOUN
afs-72863	224	9	(	(	PUNCT
afs-72863	224	10	pi	pi	NOUN
afs-72863	224	11	,	,	PUNCT
afs-72863	224	12	p2	p2	PROPN
afs-72863	224	13	)	)	PUNCT
afs-72863	224	14	,	,	PUNCT
afs-72863	224	15	the	the	DET
afs-72863	224	16	signal	signal	ADJ
afs-72863	224	17	sequence	sequence	NOUN
afs-72863	224	18	(	(	PUNCT
afs-72863	224	19	ss	ss	NOUN
afs-72863	224	20	)	)	PUNCT
afs-72863	224	21	and	and	CCONJ
afs-72863	224	22	the	the	DET
afs-72863	224	23	transcription	transcription	NOUN
afs-72863	224	24	terminator	terminator	NOUN
afs-72863	224	25	(	(	PUNCT
afs-72863	224	26	,	,	PUNCT
afs-72863	224	27	tslpa	tslpa	NOUN
afs-72863	224	28	)	)	PUNCT
afs-72863	224	29	of	of	ADP
afs-72863	224	30	the	the	DET
afs-72863	224	31	l.	l.	PROPN
afs-72863	224	32	brevis	brevis	PROPN
afs-72863	224	33	slpa	slpa	NOUN
afs-72863	224	34	and	and	CCONJ
afs-72863	224	35	another	another	DET
afs-72863	224	36	terminator	terminator	NOUN
afs-72863	224	37	(	(	PUNCT
afs-72863	224	38	t	t	NOUN
afs-72863	224	39	)	)	PUNCT
afs-72863	224	40	upstream	upstream	NOUN
afs-72863	224	41	of	of	ADP
afs-72863	224	42	slpa	slpa	NOUN
afs-72863	224	43	.	.	PUNCT
afs-72863	225	1	the	the	DET
afs-72863	225	2	reporter	reporter	NOUN
afs-72863	225	3	gene	gene	NOUN
afs-72863	225	4	was	be	AUX
afs-72863	225	5	the	the	DET
afs-72863	225	6	b	b	NOUN
afs-72863	225	7	-	-	PUNCT
afs-72863	225	8	lactamase	lactamase	ADJ
afs-72863	225	9	(	(	PUNCT
afs-72863	225	10	bla	bla	NOUN
afs-72863	225	11	)	)	PUNCT
afs-72863	225	12	of	of	ADP
afs-72863	225	13	puci9	puci9	PROPN
afs-72863	225	14	.	.	PUNCT
afs-72863	226	1	the	the	DET
afs-72863	226	2	secretion	secretion	NOUN
afs-72863	226	3	vector	vector	NOUN
afs-72863	226	4	(	(	PUNCT
afs-72863	226	5	pkth2i2i	pkth2i2i	PROPN
afs-72863	226	6	,	,	PUNCT
afs-72863	226	7	see	see	VERB
afs-72863	226	8	fig	fig	NOUN
afs-72863	226	9	.	.	PUNCT
afs-72863	227	1	2	2	X
afs-72863	227	2	)	)	PUNCT
afs-72863	227	3	was	be	AUX
afs-72863	227	4	constructed	construct	VERB
afs-72863	227	5	stepwise	stepwise	NOUN
afs-72863	227	6	by	by	ADP
afs-72863	227	7	pcr	pcr	PROPN
afs-72863	227	8	(	(	PUNCT
afs-72863	227	9	savijoki	savijoki	NOUN
afs-72863	227	10	et	et	PROPN
afs-72863	227	11	al	al	PROPN
afs-72863	227	12	.	.	PROPN
afs-72863	227	13	1997	1997	NUM
afs-72863	227	14	)	)	PUNCT
afs-72863	227	15	.	.	PUNCT
afs-72863	228	1	to	to	PART
afs-72863	228	2	analyse	analyse	VERB
afs-72863	228	3	the	the	DET
afs-72863	228	4	expression	expression	NOUN
afs-72863	228	5	and	and	CCONJ
afs-72863	228	6	secretion	secretion	NOUN
afs-72863	228	7	of	of	ADP
afs-72863	228	8	bla	bla	NOUN
afs-72863	228	9	with	with	ADP
afs-72863	228	10	the	the	DET
afs-72863	228	11	slpa	slpa	ADJ
afs-72863	228	12	cassette	cassette	NOUN
afs-72863	228	13	,	,	PUNCT
afs-72863	228	14	we	we	PRON
afs-72863	228	15	first	first	ADV
afs-72863	228	16	transformed	transform	VERB
afs-72863	228	17	l.	l.	PROPN
afs-72863	228	18	lactis	lactis	PROPN
afs-72863	228	19	(	(	PUNCT
afs-72863	228	20	mg	mg	PROPN
afs-72863	228	21	1614	1614	NUM
afs-72863	228	22	)	)	PUNCT
afs-72863	228	23	with	with	ADP
afs-72863	228	24	pkth2i2i	pkth2i2i	PROPN
afs-72863	228	25	.	.	PUNCT
afs-72863	229	1	the	the	DET
afs-72863	229	2	transformants	transformant	NOUN
afs-72863	229	3	kept	keep	VERB
afs-72863	229	4	the	the	DET
afs-72863	229	5	vector	vector	NOUN
afs-72863	229	6	stabile	stabile	ADJ
afs-72863	229	7	and	and	CCONJ
afs-72863	229	8	efficiently	efficiently	ADV
afs-72863	229	9	secreted	secrete	VERB
afs-72863	229	10	b	b	NOUN
afs-72863	229	11	-	-	PUNCT
afs-72863	229	12	lactamase	lactamase	NOUN
afs-72863	229	13	into	into	ADP
afs-72863	229	14	the	the	DET
afs-72863	229	15	culture	culture	NOUN
afs-72863	229	16	medium	medium	NOUN
afs-72863	229	17	.	.	PUNCT
afs-72863	230	1	the	the	DET
afs-72863	230	2	utility	utility	NOUN
afs-72863	230	3	of	of	ADP
afs-72863	230	4	the	the	DET
afs-72863	230	5	cassette	cassette	NOUN
afs-72863	230	6	in	in	ADP
afs-72863	230	7	other	other	ADJ
afs-72863	230	8	lab	lab	NOUN
afs-72863	230	9	was	be	AUX
afs-72863	230	10	confirmed	confirm	VERB
afs-72863	230	11	by	by	ADP
afs-72863	230	12	transferring	transfer	VERB
afs-72863	230	13	pkth2i2i	pkth2i2i	PROPN
afs-72863	230	14	into	into	ADP
afs-72863	230	15	l.	l.	PROPN
afs-72863	230	16	brevis	brevis	PROPN
afs-72863	230	17	(	(	PUNCT
afs-72863	230	18	atccb2b7	atccb2b7	NUM
afs-72863	230	19	)	)	PUNCT
afs-72863	230	20	,	,	PUNCT
afs-72863	230	21	l.	l.	PROPN
afs-72863	230	22	plantarum	plantarum	PROPN
afs-72863	230	23	(	(	PUNCT
afs-72863	230	24	ncdo	ncdo	NOUN
afs-72863	230	25	1193	1193	NUM
afs-72863	230	26	)	)	PUNCT
afs-72863	230	27	,	,	PUNCT
afs-72863	230	28	l.	l.	PROPN
afs-72863	230	29	gasseri	gasseri	PROPN
afs-72863	230	30	(	(	PUNCT
afs-72863	230	31	nck	nck	NOUN
afs-72863	230	32	334	334	NUM
afs-72863	230	33	)	)	PUNCT
afs-72863	230	34	and	and	CCONJ
afs-72863	230	35	l.	l.	PROPN
afs-72863	230	36	casei	casei	PROPN
afs-72863	230	37	(	(	PUNCT
afs-72863	230	38	atcc	atcc	NOUN
afs-72863	230	39	393	393	NUM
afs-72863	230	40	)	)	PUNCT
afs-72863	230	41	hosts	host	NOUN
afs-72863	230	42	and	and	CCONJ
afs-72863	230	43	studying	study	VERB
afs-72863	230	44	the	the	DET
afs-72863	230	45	expression	expression	NOUN
afs-72863	230	46	and	and	CCONJ
afs-72863	230	47	secretion	secretion	NOUN
afs-72863	230	48	of	of	ADP
afs-72863	230	49	6	6	NUM
afs-72863	230	50	-	-	PUNCT
afs-72863	230	51	lactamase	lactamase	NOUN
afs-72863	230	52	as	as	ADP
afs-72863	230	53	a	a	DET
afs-72863	230	54	function	function	NOUN
afs-72863	230	55	of	of	ADP
afs-72863	230	56	growth	growth	NOUN
afs-72863	230	57	in	in	ADP
afs-72863	230	58	flask	flask	NOUN
afs-72863	230	59	cultivations	cultivation	NOUN
afs-72863	230	60	.	.	PUNCT
afs-72863	231	1	in	in	ADP
afs-72863	231	2	each	each	DET
afs-72863	231	3	strain	strain	NOUN
afs-72863	231	4	carrying	carry	VERB
afs-72863	231	5	pkth2i2i	pkth2i2i	NOUN
afs-72863	231	6	,	,	PUNCT
afs-72863	231	7	all	all	DET
afs-72863	231	8	detectable	detectable	ADJ
afs-72863	231	9	bla	bla	NOUN
afs-72863	231	10	activity	activity	NOUN
afs-72863	231	11	was	be	AUX
afs-72863	231	12	in	in	ADP
afs-72863	231	13	the	the	DET
afs-72863	231	14	growth	growth	NOUN
afs-72863	231	15	medium	medium	NOUN
afs-72863	231	16	.	.	PUNCT
afs-72863	232	1	the	the	DET
afs-72863	232	2	highest	high	ADJ
afs-72863	232	3	yield	yield	NOUN
afs-72863	232	4	(	(	PUNCT
afs-72863	232	5	10240	10240	NUM
afs-72863	232	6	u	u	NOUN
afs-72863	232	7	/	/	SYM
afs-72863	232	8	ml	ml	PROPN
afs-72863	232	9	;	;	PUNCT
afs-72863	232	10	50	50	NUM
afs-72863	232	11	mg	mg	NOUN
afs-72863	232	12	bla/1	bla/1	PROPN
afs-72863	232	13	)	)	PUNCT
afs-72863	232	14	in	in	ADP
afs-72863	232	15	the	the	DET
afs-72863	232	16	culture	culture	NOUN
afs-72863	232	17	supernatants	supernatant	NOUN
afs-72863	232	18	was	be	AUX
afs-72863	232	19	obtained	obtain	VERB
afs-72863	232	20	with	with	ADP
afs-72863	232	21	l.	l.	PROPN
afs-72863	232	22	lactis	lactis	PROPN
afs-72863	232	23	at	at	ADP
afs-72863	232	24	the	the	DET
afs-72863	232	25	early	early	ADJ
afs-72863	232	26	stationary	stationary	ADJ
afs-72863	232	27	phase	phase	NOUN
afs-72863	232	28	.	.	PUNCT
afs-72863	233	1	the	the	DET
afs-72863	233	2	highest	high	ADJ
afs-72863	233	3	production	production	NOUN
afs-72863	233	4	level	level	NOUN
afs-72863	233	5	ofbla	ofbla	NOUN
afs-72863	233	6	in	in	ADP
afs-72863	233	7	the	the	DET
afs-72863	233	8	early	early	ADJ
afs-72863	233	9	stationary	stationary	ADJ
afs-72863	233	10	phase	phase	NOUN
afs-72863	233	11	l.	l.	PROPN
afs-72863	233	12	brevis	brevis	PROPN
afs-72863	233	13	cells	cell	NOUN
afs-72863	233	14	and	and	CCONJ
afs-72863	233	15	in	in	ADP
afs-72863	233	16	the	the	DET
afs-72863	233	17	exponential	exponential	ADJ
afs-72863	233	18	phase	phase	NOUN
afs-72863	233	19	l.	l.	PROPN
afs-72863	233	20	plantarum	plantarum	PROPN
afs-72863	233	21	cells	cell	NOUN
afs-72863	233	22	was	be	AUX
afs-72863	233	23	60	60	NUM
afs-72863	233	24	%	%	NOUN
afs-72863	233	25	and	and	CCONJ
afs-72863	233	26	30	30	NUM
afs-72863	233	27	%	%	NOUN
afs-72863	233	28	,	,	PUNCT
afs-72863	233	29	respectively	respectively	ADV
afs-72863	233	30	,	,	PUNCT
afs-72863	233	31	of	of	ADP
afs-72863	233	32	that	that	PRON
afs-72863	233	33	in	in	ADP
afs-72863	233	34	l.	l.	PROPN
afs-72863	233	35	lactis	lactis	PROPN
afs-72863	233	36	(	(	PUNCT
afs-72863	233	37	savijoki	savijoki	NOUN
afs-72863	233	38	et	et	PROPN
afs-72863	233	39	al	al	PROPN
afs-72863	233	40	.	.	PROPN
afs-72863	233	41	1997	1997	NUM
afs-72863	233	42	)	)	PUNCT
afs-72863	233	43	.	.	PUNCT
afs-72863	234	1	the	the	DET
afs-72863	234	2	rate	rate	NOUN
afs-72863	234	3	of	of	ADP
afs-72863	234	4	bla	bla	NOUN
afs-72863	234	5	production	production	NOUN
afs-72863	234	6	was	be	AUX
afs-72863	234	7	roughly	roughly	ADV
afs-72863	234	8	equal	equal	ADJ
afs-72863	234	9	in	in	ADP
afs-72863	234	10	l.	l.	PROPN
afs-72863	234	11	lactis	lactis	PROPN
afs-72863	234	12	and	and	CCONJ
afs-72863	234	13	l.	l.	PROPN
afs-72863	234	14	plantarum	plantarum	PROPN
afs-72863	234	15	,	,	PUNCT
afs-72863	234	16	whereas	whereas	SCONJ
afs-72863	234	17	that	that	SCONJ
afs-72863	234	18	ofl	ofl	PROPN
afs-72863	234	19	.	.	PROPN
afs-72863	234	20	brevis	brevis	PROPN
afs-72863	234	21	was	be	AUX
afs-72863	234	22	somewhat	somewhat	ADV
afs-72863	234	23	slower	slow	ADJ
afs-72863	234	24	.	.	PUNCT
afs-72863	235	1	in	in	ADP
afs-72863	235	2	all	all	DET
afs-72863	235	3	strains	strain	NOUN
afs-72863	235	4	studied	study	VERB
afs-72863	235	5	,	,	PUNCT
afs-72863	235	6	we	we	PRON
afs-72863	235	7	observed	observe	VERB
afs-72863	235	8	degradation	degradation	NOUN
afs-72863	235	9	of	of	ADP
afs-72863	235	10	6	6	NUM
afs-72863	235	11	-	-	PUNCT
afs-72863	235	12	lactamase	lactamase	NOUN
afs-72863	235	13	due	due	ADP
afs-72863	235	14	to	to	ADP
afs-72863	235	15	proteolysis	proteolysis	NOUN
afs-72863	235	16	.	.	PUNCT
afs-72863	236	1	with	with	ADP
afs-72863	236	2	l.	l.	PROPN
afs-72863	236	3	plantarum	plantarum	PROPN
afs-72863	236	4	,	,	PUNCT
afs-72863	236	5	l.	l.	PROPN
afs-72863	236	6	gas276	gas276	PROPN
afs-72863	236	7	seminar	seminar	NOUN
afs-72863	236	8	in	in	ADP
afs-72863	236	9	honour	honour	NOUN
afs-72863	236	10	of	of	ADP
afs-72863	236	11	the	the	DET
afs-72863	236	12	100th	100th	ADJ
afs-72863	236	13	anniversary	anniversary	NOUN
afs-72863	236	14	ofmtt	ofmtt	NOUN
afs-72863	236	15	agricultural	agricultural	ADJ
afs-72863	236	16	and	and	CCONJ
afs-72863	236	17	food	food	NOUN
afs-72863	236	18	science	science	NOUN
afs-72863	236	19	in	in	ADP
afs-72863	236	20	finland	finland	PROPN
afs-72863	236	21	seri	seri	PROPN
afs-72863	236	22	and	and	CCONJ
afs-72863	236	23	l.	l.	PROPN
afs-72863	236	24	casei	casei	VERB
afs-72863	236	25	the	the	DET
afs-72863	236	26	bla	bla	NOUN
afs-72863	236	27	activity	activity	NOUN
afs-72863	236	28	was	be	AUX
afs-72863	236	29	already	already	ADV
afs-72863	236	30	much	much	ADV
afs-72863	236	31	lower	low	ADJ
afs-72863	236	32	at	at	ADP
afs-72863	236	33	the	the	DET
afs-72863	236	34	early	early	ADJ
afs-72863	236	35	stationary	stationary	ADJ
afs-72863	236	36	phase	phase	NOUN
afs-72863	236	37	,	,	PUNCT
afs-72863	236	38	suggesting	suggest	VERB
afs-72863	236	39	higher	high	ADJ
afs-72863	236	40	protease	protease	NOUN
afs-72863	236	41	activity	activity	NOUN
afs-72863	236	42	in	in	ADP
afs-72863	236	43	these	these	DET
afs-72863	236	44	strains	strain	NOUN
afs-72863	236	45	.	.	PUNCT
afs-72863	237	1	comparison	comparison	NOUN
afs-72863	237	2	of	of	ADP
afs-72863	237	3	the	the	DET
afs-72863	237	4	activity	activity	NOUN
afs-72863	237	5	and	and	CCONJ
afs-72863	237	6	amount	amount	NOUN
afs-72863	237	7	of	of	ADP
afs-72863	237	8	bla	bla	NOUN
afs-72863	237	9	protein	protein	NOUN
afs-72863	237	10	by	by	ADP
afs-72863	237	11	western	western	ADJ
afs-72863	237	12	blots	blot	NOUN
afs-72863	237	13	revealed	reveal	VERB
afs-72863	237	14	a	a	DET
afs-72863	237	15	good	good	ADJ
afs-72863	237	16	correlation	correlation	NOUN
afs-72863	237	17	and	and	CCONJ
afs-72863	237	18	lack	lack	NOUN
afs-72863	237	19	of	of	ADP
afs-72863	237	20	cell	cell	NOUN
afs-72863	237	21	associated	associate	VERB
afs-72863	237	22	6	6	NUM
afs-72863	237	23	-	-	PUNCT
afs-72863	237	24	lactamase	lactamase	NOUN
afs-72863	237	25	.	.	PUNCT
afs-72863	238	1	the	the	DET
afs-72863	238	2	size	size	NOUN
afs-72863	238	3	of	of	ADP
afs-72863	238	4	bla	bla	NOUN
afs-72863	238	5	secreted	secrete	VERB
afs-72863	238	6	to	to	ADP
afs-72863	238	7	the	the	DET
afs-72863	238	8	culture	culture	NOUN
afs-72863	238	9	medium	medium	NOUN
afs-72863	238	10	was	be	AUX
afs-72863	238	11	equal	equal	ADJ
afs-72863	238	12	to	to	ADP
afs-72863	238	13	that	that	PRON
afs-72863	238	14	of	of	ADP
afs-72863	238	15	the	the	DET
afs-72863	238	16	mature	mature	ADJ
afs-72863	238	17	bla	bla	NOUN
afs-72863	238	18	of	of	ADP
afs-72863	238	19	e.	e.	PROPN
afs-72863	238	20	coli	coli	PROPN
afs-72863	238	21	,	,	PUNCT
afs-72863	238	22	suggesting	suggest	VERB
afs-72863	238	23	that	that	SCONJ
afs-72863	238	24	the	the	DET
afs-72863	238	25	enzyme	enzyme	NOUN
afs-72863	238	26	was	be	AUX
afs-72863	238	27	correctly	correctly	ADV
afs-72863	238	28	processed	process	VERB
afs-72863	238	29	.	.	PUNCT
afs-72863	239	1	the	the	DET
afs-72863	239	2	l.	l.	PROPN
afs-72863	239	3	brevis	brevis	PROPN
afs-72863	239	4	slpa	slpa	PROPN
afs-72863	239	5	promoters	promoter	NOUN
afs-72863	239	6	were	be	AUX
afs-72863	239	7	very	very	ADV
afs-72863	239	8	efficiently	efficiently	ADV
afs-72863	239	9	recognized	recognize	VERB
afs-72863	239	10	in	in	ADP
afs-72863	239	11	l.	l.	PROPN
afs-72863	239	12	lactis	lactis	PROPN
afs-72863	239	13	,	,	PUNCT
afs-72863	239	14	l.	l.	PROPN
afs-72863	239	15	brevis	brevis	PROPN
afs-72863	239	16	and	and	CCONJ
afs-72863	239	17	l.	l.	PROPN
afs-72863	239	18	plantarum	plantarum	PROPN
afs-72863	239	19	,	,	PUNCT
afs-72863	239	20	whereas	whereas	SCONJ
afs-72863	239	21	in	in	ADP
afs-72863	239	22	l.	l.	PROPN
afs-72863	239	23	gasseri	gasseri	PROPN
afs-72863	239	24	,	,	PUNCT
afs-72863	239	25	the	the	DET
afs-72863	239	26	slpa	slpa	ADJ
afs-72863	239	27	promoter	promoter	NOUN
afs-72863	239	28	region	region	NOUN
afs-72863	239	29	appeared	appear	VERB
afs-72863	239	30	to	to	PART
afs-72863	239	31	be	be	AUX
afs-72863	239	32	recognised	recognise	VERB
afs-72863	239	33	at	at	ADP
afs-72863	239	34	a	a	DET
afs-72863	239	35	lower	low	ADJ
afs-72863	239	36	level	level	NOUN
afs-72863	239	37	and	and	CCONJ
afs-72863	239	38	in	in	ADP
afs-72863	239	39	l.	l.	PROPN
afs-72863	239	40	casei	casei	VERB
afs-72863	239	41	the	the	DET
afs-72863	239	42	level	level	NOUN
afs-72863	239	43	of	of	ADP
afs-72863	239	44	transcripts	transcript	NOUN
afs-72863	239	45	was	be	AUX
afs-72863	239	46	below	below	ADP
afs-72863	239	47	the	the	DET
afs-72863	239	48	detection	detection	NOUN
afs-72863	239	49	limit	limit	NOUN
afs-72863	239	50	(	(	PUNCT
afs-72863	239	51	savijoki	savijoki	NOUN
afs-72863	239	52	et	et	PROPN
afs-72863	239	53	al	al	PROPN
afs-72863	239	54	.	.	PROPN
afs-72863	239	55	1997	1997	NUM
afs-72863	239	56	)	)	PUNCT
afs-72863	239	57	.	.	PUNCT
afs-72863	240	1	furthermore	furthermore	ADV
afs-72863	240	2	,	,	PUNCT
afs-72863	240	3	high	high	ADJ
afs-72863	240	4	integrity	integrity	NOUN
afs-72863	240	5	and	and	CCONJ
afs-72863	240	6	the	the	DET
afs-72863	240	7	correct	correct	ADJ
afs-72863	240	8	size	size	NOUN
afs-72863	240	9	of	of	ADP
afs-72863	240	10	bla	bla	PROPN
afs-72863	240	11	mrna	mrna	PROPN
afs-72863	240	12	were	be	AUX
afs-72863	240	13	demonstrated	demonstrate	VERB
afs-72863	240	14	in	in	ADP
afs-72863	240	15	all	all	DET
afs-72863	240	16	these	these	DET
afs-72863	240	17	species	specie	NOUN
afs-72863	240	18	except	except	SCONJ
afs-72863	240	19	l.	l.	PROPN
afs-72863	240	20	casei	casei	PROPN
afs-72863	240	21	.	.	PUNCT
afs-72863	241	1	fig	fig	NOUN
afs-72863	241	2	.	.	PUNCT
afs-72863	242	1	2	2	X
afs-72863	242	2	.	.	X
afs-72863	242	3	secretion	secretion	NOUN
afs-72863	242	4	and	and	CCONJ
afs-72863	242	5	expression	expression	NOUN
afs-72863	242	6	vectors	vector	NOUN
afs-72863	242	7	based	base	VERB
afs-72863	242	8	on	on	ADP
afs-72863	242	9	the	the	DET
afs-72863	242	10	a	a	DET
afs-72863	242	11	slpa	slpa	ADJ
afs-72863	242	12	expression	expression	NOUN
afs-72863	242	13	and	and	CCONJ
afs-72863	242	14	secretion	secretion	NOUN
afs-72863	242	15	signals	signal	NOUN
afs-72863	242	16	.	.	PUNCT
afs-72863	243	1	a.	a.	NOUN
afs-72863	243	2	the	the	DET
afs-72863	243	3	l.	l.	PROPN
afs-72863	243	4	brevis	brevis	PROPN
afs-72863	243	5	promotersignal	promotersignal	ADJ
afs-72863	243	6	sequence	sequence	NOUN
afs-72863	243	7	(	(	PUNCT
afs-72863	243	8	p	p	NOUN
afs-72863	243	9	sl	sl	VERB
afs-72863	243	10	a	a	DET
afs-72863	243	11	-ssd	-ssd	NOUN
afs-72863	243	12	a	a	PRON
afs-72863	243	13	)	)	PUNCT
afs-72863	243	14	region	region	NOUN
afs-72863	243	15	,	,	PUNCT
afs-72863	243	16	the	the	DET
afs-72863	243	17	transcription	transcription	NOUN
afs-72863	243	18	terminators	terminator	NOUN
afs-72863	243	19	(	(	PUNCT
afs-72863	243	20	r	r	NOUN
afs-72863	243	21	and	and	CCONJ
afs-72863	243	22	tsha	tsha	PROPN
afs-72863	243	23	)	)	PUNCT
afs-72863	243	24	and	and	CCONJ
afs-72863	243	25	the	the	DET
afs-72863	243	26	e.	e.	PROPN
afs-72863	243	27	coll	coll	PROPN
afs-72863	243	28	b	b	PROPN
afs-72863	243	29	-	-	PUNCT
afs-72863	243	30	lactamase	lactamase	ADJ
afs-72863	243	31	(	(	PUNCT
afs-72863	243	32	bla	bla	NOUN
afs-72863	243	33	)	)	PUNCT
afs-72863	243	34	gene	gene	NOUN
afs-72863	243	35	were	be	AUX
afs-72863	243	36	isolated	isolate	VERB
afs-72863	243	37	by	by	ADP
afs-72863	243	38	pcr	pcr	ADJ
afs-72863	243	39	amplifications	amplification	NOUN
afs-72863	243	40	and	and	CCONJ
afs-72863	243	41	joined	join	VERB
afs-72863	243	42	stepwise	stepwise	NOUN
afs-72863	243	43	to	to	PART
afs-72863	243	44	form	form	VERB
afs-72863	243	45	the	the	DET
afs-72863	243	46	final	final	ADJ
afs-72863	243	47	t	t	PROPN
afs-72863	243	48	-	-	PUNCT
afs-72863	243	49	psha	psha	NOUN
afs-72863	243	50	-	-	PUNCT
afs-72863	243	51	sssl	sssl	VERB
afs-72863	243	52	a	a	DET
afs-72863	243	53	-bla	-bla	NOUN
afs-72863	243	54	-	-	PUNCT
afs-72863	243	55	tsl	tsl	PROPN
afs-72863	243	56	a	a	DET
afs-72863	243	57	cassette	cassette	NOUN
afs-72863	243	58	,	,	PUNCT
afs-72863	243	59	which	which	PRON
afs-72863	243	60	was	be	AUX
afs-72863	243	61	then	then	ADV
afs-72863	243	62	ligated	ligate	VERB
afs-72863	243	63	with	with	ADP
afs-72863	243	64	pkth2o9s	pkth2o9s	PROPN
afs-72863	243	65	to	to	PART
afs-72863	243	66	result	result	VERB
afs-72863	243	67	in	in	ADP
afs-72863	243	68	pkth2i2i	pkth2i2i	PROPN
afs-72863	243	69	.	.	PUNCT
afs-72863	244	1	the	the	DET
afs-72863	244	2	nucleotide	nucleotide	NOUN
afs-72863	244	3	and	and	CCONJ
afs-72863	244	4	the	the	DET
afs-72863	244	5	corresponding	corresponding	ADJ
afs-72863	244	6	amino	amino	ADJ
afs-72863	244	7	acid	acid	NOUN
afs-72863	244	8	sequences	sequence	NOUN
afs-72863	244	9	of	of	ADP
afs-72863	244	10	the	the	DET
afs-72863	244	11	prf	prf	PROPN
afs-72863	244	12	a	a	PROPN
afs-72863	244	13	-	-	INTJ
afs-72863	244	14	ss	ss	NOUN
afs-72863	244	15	.	.	PUNCT
afs-72863	245	1	a	a	DET
afs-72863	245	2	-bla	-bla	NOUN
afs-72863	245	3	joint	joint	ADJ
afs-72863	245	4	region	region	NOUN
afs-72863	245	5	of	of	ADP
afs-72863	245	6	the	the	DET
afs-72863	245	7	secretion	secretion	NOUN
afs-72863	245	8	construct	construct	NOUN
afs-72863	245	9	are	be	AUX
afs-72863	245	10	shown	show	VERB
afs-72863	245	11	,	,	PUNCT
afs-72863	245	12	and	and	CCONJ
afs-72863	245	13	the	the	DET
afs-72863	245	14	signal	signal	ADJ
afs-72863	245	15	peptide	peptide	NOUN
afs-72863	245	16	cleavage	cleavage	NOUN
afs-72863	245	17	site	site	NOUN
afs-72863	245	18	is	be	AUX
afs-72863	245	19	indicated	indicate	VERB
afs-72863	245	20	by	by	ADP
afs-72863	245	21	a	a	DET
afs-72863	245	22	vertical	vertical	ADJ
afs-72863	245	23	arrow	arrow	NOUN
afs-72863	245	24	.	.	PUNCT
afs-72863	246	1	the	the	DET
afs-72863	246	2	reporter	reporter	NOUN
afs-72863	246	3	gene	gene	PROPN
afs-72863	246	4	region	region	PROPN
afs-72863	246	5	is	be	AUX
afs-72863	246	6	underlined	underline	VERB
afs-72863	246	7	.	.	PUNCT
afs-72863	247	1	b.	b.	PROPN
afs-72863	248	1	the	the	DET
afs-72863	248	2	expression	expression	NOUN
afs-72863	248	3	cassette	cassette	NOUN
afs-72863	248	4	consisting	consist	VERB
afs-72863	248	5	of	of	ADP
afs-72863	248	6	the	the	DET
afs-72863	248	7	l.	l.	PROPN
afs-72863	248	8	brevis	brevis	PROPN
afs-72863	248	9	slpa	slpa	ADJ
afs-72863	248	10	promoter	promoter	NOUN
afs-72863	248	11	region	region	NOUN
afs-72863	248	12	and	and	CCONJ
afs-72863	248	13	the	the	DET
afs-72863	248	14	reporter	reporter	NOUN
afs-72863	248	15	gene	gene	NOUN
afs-72863	248	16	(	(	PUNCT
afs-72863	248	17	gus	gus	PROPN
afs-72863	248	18	,	,	PUNCT
afs-72863	248	19	luc	luc	PROPN
afs-72863	248	20	and	and	CCONJ
afs-72863	248	21	pepn	pepn	NOUN
afs-72863	248	22	)	)	PUNCT
afs-72863	248	23	with	with	ADP
afs-72863	248	24	the	the	DET
afs-72863	248	25	nucleotide	nucleotide	NOUN
afs-72863	248	26	and	and	CCONJ
afs-72863	248	27	the	the	DET
afs-72863	248	28	corresponding	corresponding	ADJ
afs-72863	248	29	amino	amino	ADJ
afs-72863	248	30	acid	acid	NOUN
afs-72863	248	31	sequences	sequence	NOUN
afs-72863	248	32	of	of	ADP
afs-72863	248	33	the	the	DET
afs-72863	248	34	joint	joint	ADJ
afs-72863	248	35	region	region	NOUN
afs-72863	248	36	.	.	PUNCT
afs-72863	249	1	the	the	DET
afs-72863	249	2	genes	gene	NOUN
afs-72863	249	3	,	,	PUNCT
afs-72863	249	4	which	which	PRON
afs-72863	249	5	were	be	AUX
afs-72863	249	6	isolated	isolate	VERB
afs-72863	249	7	using	use	VERB
afs-72863	249	8	pcr	pcr	NOUN
afs-72863	249	9	,	,	PUNCT
afs-72863	249	10	contained	contain	VERB
afs-72863	249	11	a	a	DET
afs-72863	249	12	sequence	sequence	NOUN
afs-72863	249	13	coding	code	VERB
afs-72863	249	14	for	for	ADP
afs-72863	249	15	the	the	DET
afs-72863	249	16	mature	mature	ADJ
afs-72863	249	17	part	part	NOUN
afs-72863	249	18	of	of	ADP
afs-72863	249	19	the	the	DET
afs-72863	249	20	polypeptide	polypeptide	NOUN
afs-72863	249	21	.	.	PUNCT
afs-72863	250	1	the	the	DET
afs-72863	250	2	reporter	reporter	NOUN
afs-72863	250	3	gene	gene	PROPN
afs-72863	250	4	region	region	PROPN
afs-72863	250	5	is	be	AUX
afs-72863	250	6	underlined	underline	VERB
afs-72863	250	7	and	and	CCONJ
afs-72863	250	8	the	the	DET
afs-72863	250	9	amino	amino	NOUN
afs-72863	250	10	acid	acid	NOUN
afs-72863	250	11	residues	residue	NOUN
afs-72863	250	12	derived	derive	VERB
afs-72863	250	13	from	from	ADP
afs-72863	250	14	the	the	DET
afs-72863	250	15	respective	respective	ADJ
afs-72863	250	16	restriction	restriction	NOUN
afs-72863	250	17	enzyme	enzyme	NOUN
afs-72863	250	18	recognition	recognition	NOUN
afs-72863	250	19	sites	site	NOUN
afs-72863	250	20	are	be	AUX
afs-72863	250	21	marked	mark	VERB
afs-72863	250	22	with	with	ADP
afs-72863	250	23	dotted	dotted	ADJ
afs-72863	250	24	lines	line	NOUN
afs-72863	250	25	.	.	PUNCT
afs-72863	251	1	277	277	NUM
afs-72863	251	2	vol	vol	NOUN
afs-72863	251	3	.	.	PUNCT
afs-72863	251	4	7	7	NUM
afs-72863	251	5	(	(	PUNCT
afs-72863	251	6	1998	1998	NUM
afs-72863	251	7	):	):	PUNCT
afs-72863	251	8	267	267	NUM
afs-72863	251	9	-	-	SYM
afs-72863	251	10	282	282	NUM
afs-72863	251	11	.	.	PUNCT
afs-72863	251	12	agricultural	agricultural	ADJ
afs-72863	251	13	and	and	CCONJ
afs-72863	251	14	food	food	NOUN
afs-72863	251	15	science	science	NOUN
afs-72863	251	16	in	in	ADP
afs-72863	251	17	finland	finland	PROPN
afs-72863	251	18	to	to	PART
afs-72863	251	19	improve	improve	VERB
afs-72863	251	20	the	the	DET
afs-72863	251	21	stability	stability	NOUN
afs-72863	251	22	and	and	CCONJ
afs-72863	251	23	production	production	NOUN
afs-72863	251	24	of	of	ADP
afs-72863	251	25	b	b	NOUN
afs-72863	251	26	-	-	PUNCT
afs-72863	251	27	lactamase	lactamase	NOUN
afs-72863	251	28	,	,	PUNCT
afs-72863	251	29	we	we	PRON
afs-72863	251	30	grew	grow	VERB
afs-72863	251	31	l.	l.	PROPN
afs-72863	251	32	lactis	lactis	PROPN
afs-72863	251	33	in	in	ADP
afs-72863	251	34	a	a	DET
afs-72863	251	35	bioreactor	bioreactor	NOUN
afs-72863	251	36	at	at	ADP
afs-72863	251	37	constant	constant	ADJ
afs-72863	251	38	ph	ph	NOUN
afs-72863	251	39	and	and	CCONJ
afs-72863	251	40	glucose	glucose	NOUN
afs-72863	251	41	feeding	feeding	NOUN
afs-72863	251	42	(	(	PUNCT
afs-72863	251	43	fig	fig	NOUN
afs-72863	251	44	.	.	PUNCT
afs-72863	252	1	3	3	NUM
afs-72863	252	2	)	)	PUNCT
afs-72863	252	3	.	.	PUNCT
afs-72863	253	1	under	under	ADP
afs-72863	253	2	such	such	ADJ
afs-72863	253	3	conditions	condition	NOUN
afs-72863	253	4	the	the	DET
afs-72863	253	5	yield	yield	NOUN
afs-72863	253	6	of	of	ADP
afs-72863	253	7	bla	bla	NOUN
afs-72863	253	8	could	could	AUX
afs-72863	253	9	be	be	AUX
afs-72863	253	10	increased	increase	VERB
afs-72863	253	11	up	up	ADP
afs-72863	253	12	to	to	PART
afs-72863	253	13	80	80	NUM
afs-72863	253	14	mg/	mg/	NOUN
afs-72863	253	15	1	1	NUM
afs-72863	253	16	(	(	PUNCT
afs-72863	253	17	savijoki	savijoki	NOUN
afs-72863	253	18	et	et	PROPN
afs-72863	253	19	al	al	PROPN
afs-72863	253	20	.	.	PROPN
afs-72863	253	21	1997	1997	NUM
afs-72863	253	22	)	)	PUNCT
afs-72863	253	23	.	.	PUNCT
afs-72863	254	1	after	after	SCONJ
afs-72863	254	2	maximum	maximum	ADJ
afs-72863	254	3	activity	activity	NOUN
afs-72863	254	4	was	be	AUX
afs-72863	254	5	reached	reach	VERB
afs-72863	254	6	(	(	PUNCT
afs-72863	254	7	10	10	NUM
afs-72863	254	8	after	after	ADP
afs-72863	254	9	the	the	DET
afs-72863	254	10	cell	cell	NOUN
afs-72863	254	11	density	density	NOUN
afs-72863	254	12	a600	a600	PROPN
afs-72863	254	13	=	=	PROPN
afs-72863	254	14	l	l	NOUN
afs-72863	254	15	)	)	PUNCT
afs-72863	254	16	the	the	DET
afs-72863	254	17	level	level	NOUN
afs-72863	254	18	of	of	ADP
afs-72863	254	19	6	6	NUM
afs-72863	254	20	-	-	PUNCT
afs-72863	254	21	lactamase	lactamase	NOUN
afs-72863	254	22	was	be	AUX
afs-72863	254	23	kept	keep	VERB
afs-72863	254	24	stabile	stabile	ADJ
afs-72863	254	25	at	at	ADP
afs-72863	254	26	the	the	DET
afs-72863	254	27	stationary	stationary	ADJ
afs-72863	254	28	phase	phase	NOUN
afs-72863	254	29	ofgrowth	ofgrowth	NOUN
afs-72863	254	30	,	,	PUNCT
afs-72863	254	31	indicating	indicate	VERB
afs-72863	254	32	stabilisation	stabilisation	NOUN
afs-72863	254	33	of	of	ADP
afs-72863	254	34	bla	bla	NOUN
afs-72863	254	35	activity	activity	NOUN
afs-72863	254	36	with	with	ADP
afs-72863	254	37	the	the	DET
afs-72863	254	38	ph	ph	ADJ
afs-72863	254	39	control	control	NOUN
afs-72863	254	40	and	and	CCONJ
afs-72863	254	41	glucose	glucose	NOUN
afs-72863	254	42	.	.	PUNCT
afs-72863	255	1	comparison	comparison	NOUN
afs-72863	255	2	of	of	ADP
afs-72863	255	3	yields	yield	NOUN
afs-72863	255	4	ofb	ofb	PROPN
afs-72863	255	5	-	-	PUNCT
afs-72863	255	6	lactamase	lactamase	PROPN
afs-72863	255	7	production	production	NOUN
afs-72863	255	8	in	in	ADP
afs-72863	255	9	lactococci	lactococci	NOUN
afs-72863	255	10	revealed	reveal	VERB
afs-72863	255	11	that	that	SCONJ
afs-72863	255	12	a	a	DET
afs-72863	255	13	hybrid	hybrid	ADJ
afs-72863	255	14	expression	expression	NOUN
afs-72863	255	15	-	-	PUNCT
afs-72863	255	16	secretion	secretion	NOUN
afs-72863	255	17	unit	unit	NOUN
afs-72863	255	18	consisting	consist	VERB
afs-72863	255	19	of	of	ADP
afs-72863	255	20	a	a	DET
afs-72863	255	21	strong	strong	ADJ
afs-72863	255	22	cytoplasmic	cytoplasmic	ADJ
afs-72863	255	23	lactococcal	lactococcal	ADJ
afs-72863	255	24	promoter	promoter	NOUN
afs-72863	255	25	and	and	CCONJ
afs-72863	255	26	an	an	DET
afs-72863	255	27	indigenous	indigenous	ADJ
afs-72863	255	28	lactococcal	lactococcal	ADJ
afs-72863	255	29	signal	signal	NOUN
afs-72863	255	30	sequence	sequence	NOUN
afs-72863	255	31	(	(	PUNCT
afs-72863	255	32	koivula	koivula	NOUN
afs-72863	255	33	et	et	PROPN
afs-72863	255	34	al	al	PROPN
afs-72863	255	35	.	.	PROPN
afs-72863	256	1	1991,sibakov	1991,sibakov	NUM
afs-72863	256	2	et	et	NOUN
afs-72863	256	3	al	al	PROPN
afs-72863	256	4	.	.	PROPN
afs-72863	256	5	1991	1991	NUM
afs-72863	256	6	)	)	PUNCT
afs-72863	256	7	resulted	result	VERB
afs-72863	256	8	in	in	ADP
afs-72863	256	9	only	only	ADV
afs-72863	256	10	14	14	NUM
afs-72863	256	11	%	%	NOUN
afs-72863	256	12	of	of	ADP
afs-72863	256	13	the	the	DET
afs-72863	256	14	bla	bla	NOUN
afs-72863	256	15	activity	activity	NOUN
afs-72863	256	16	obtained	obtain	VERB
afs-72863	256	17	with	with	ADP
afs-72863	256	18	the	the	DET
afs-72863	256	19	slpa	slpa	ADV
afs-72863	256	20	-	-	PUNCT
afs-72863	256	21	based	base	VERB
afs-72863	256	22	secretion	secretion	NOUN
afs-72863	256	23	system	system	NOUN
afs-72863	256	24	.	.	PUNCT
afs-72863	257	1	this	this	DET
afs-72863	257	2	finding	finding	NOUN
afs-72863	257	3	supports	support	VERB
afs-72863	257	4	the	the	DET
afs-72863	257	5	high	high	ADJ
afs-72863	257	6	efficiency	efficiency	NOUN
afs-72863	257	7	of	of	ADP
afs-72863	257	8	the	the	DET
afs-72863	257	9	slpa	slpa	ADJ
afs-72863	257	10	expression	expression	NOUN
afs-72863	257	11	and	and	CCONJ
afs-72863	257	12	secretion	secretion	NOUN
afs-72863	257	13	signals	signal	NOUN
afs-72863	257	14	.	.	PUNCT
afs-72863	258	1	the	the	DET
afs-72863	258	2	kinetics	kinetic	NOUN
afs-72863	258	3	of	of	ADP
afs-72863	258	4	6lactamase	6lactamase	NUM
afs-72863	258	5	accumulation	accumulation	NOUN
afs-72863	258	6	shows	show	VERB
afs-72863	258	7	that	that	SCONJ
afs-72863	258	8	the	the	DET
afs-72863	258	9	bla	bla	NOUN
afs-72863	258	10	-	-	PUNCT
afs-72863	258	11	production	production	NOUN
afs-72863	258	12	is	be	AUX
afs-72863	258	13	basically	basically	ADV
afs-72863	258	14	restricted	restrict	VERB
afs-72863	258	15	to	to	ADP
afs-72863	258	16	the	the	DET
afs-72863	258	17	exponential	exponential	ADJ
afs-72863	258	18	phase	phase	NOUN
afs-72863	258	19	of	of	ADP
afs-72863	258	20	growth	growth	NOUN
afs-72863	258	21	.	.	PUNCT
afs-72863	259	1	sixty	sixty	NUM
afs-72863	259	2	-	-	PUNCT
afs-72863	259	3	five	five	NUM
afs-72863	259	4	per	per	ADP
afs-72863	259	5	cent	cent	NOUN
afs-72863	259	6	of	of	ADP
afs-72863	259	7	the	the	DET
afs-72863	259	8	maximum	maximum	ADJ
afs-72863	259	9	bla	bla	NOUN
afs-72863	259	10	activity	activity	NOUN
afs-72863	259	11	was	be	AUX
afs-72863	259	12	reached	reach	VERB
afs-72863	259	13	within	within	ADP
afs-72863	259	14	2	2	NUM
afs-72863	259	15	h	h	NOUN
afs-72863	259	16	of	of	ADP
afs-72863	259	17	the	the	DET
afs-72863	259	18	cell	cell	NOUN
afs-72863	259	19	density	density	NOUN
afs-72863	259	20	a6oo	a6oo	PUNCT
afs-72863	260	1	=	=	SYM
afs-72863	260	2	l	l	X
afs-72863	260	3	(	(	PUNCT
afs-72863	260	4	fig	fig	NOUN
afs-72863	260	5	.	.	PUNCT
afs-72863	261	1	3	3	NUM
afs-72863	261	2	)	)	PUNCT
afs-72863	261	3	,	,	PUNCT
afs-72863	261	4	implying	imply	VERB
afs-72863	261	5	a	a	DET
afs-72863	261	6	very	very	ADV
afs-72863	261	7	high	high	ADJ
afs-72863	261	8	rate	rate	NOUN
afs-72863	261	9	of	of	ADP
afs-72863	261	10	secretion	secretion	NOUN
afs-72863	261	11	with	with	ADP
afs-72863	261	12	a	a	DET
afs-72863	261	13	calculated	calculate	VERB
afs-72863	261	14	value	value	NOUN
afs-72863	261	15	of	of	ADP
afs-72863	261	16	5	5	NUM
afs-72863	261	17	x	x	SYM
afs-72863	261	18	105	105	NUM
afs-72863	261	19	molecules	molecule	NOUN
afs-72863	261	20	/	/	SYM
afs-72863	261	21	cell	cell	NOUN
afs-72863	261	22	/	/	SYM
afs-72863	261	23	h.	h.	NOUN
afs-72863	262	1	this	this	DET
afs-72863	262	2	value	value	NOUN
afs-72863	262	3	is	be	AUX
afs-72863	262	4	comparable	comparable	ADJ
afs-72863	262	5	to	to	ADP
afs-72863	262	6	or	or	CCONJ
afs-72863	262	7	exceeds	exceed	VERB
afs-72863	262	8	the	the	DET
afs-72863	262	9	best	good	ADJ
afs-72863	262	10	exoenzyme	exoenzyme	NOUN
afs-72863	262	11	-	-	PUNCT
afs-72863	262	12	producing	produce	VERB
afs-72863	262	13	laboratory	laboratory	NOUN
afs-72863	262	14	strains	strain	NOUN
afs-72863	262	15	of	of	ADP
afs-72863	262	16	bacillus	bacillus	NOUN
afs-72863	262	17	(	(	PUNCT
afs-72863	262	18	simonen	simonen	NOUN
afs-72863	262	19	and	and	CCONJ
afs-72863	262	20	palva	palva	NOUN
afs-72863	262	21	1993	1993	NUM
afs-72863	262	22	)	)	PUNCT
afs-72863	262	23	,	,	PUNCT
afs-72863	262	24	and	and	CCONJ
afs-72863	262	25	thus	thus	ADV
afs-72863	262	26	suggests	suggest	VERB
afs-72863	262	27	utility	utility	NOUN
afs-72863	262	28	of	of	ADP
afs-72863	262	29	lactococci	lactococci	NOUN
afs-72863	262	30	as	as	ADP
afs-72863	262	31	production	production	NOUN
afs-72863	262	32	hosts	host	NOUN
afs-72863	262	33	.	.	PUNCT
afs-72863	263	1	however	however	ADV
afs-72863	263	2	,	,	PUNCT
afs-72863	263	3	lengthening	lengthen	VERB
afs-72863	263	4	the	the	DET
afs-72863	263	5	effective	effective	ADJ
afs-72863	263	6	duration	duration	NOUN
afs-72863	263	7	of	of	ADP
afs-72863	263	8	the	the	DET
afs-72863	263	9	production	production	NOUN
afs-72863	263	10	phase	phase	NOUN
afs-72863	263	11	to	to	PART
afs-72863	263	12	raise	raise	VERB
afs-72863	263	13	product	product	NOUN
afs-72863	263	14	yields	yield	NOUN
afs-72863	263	15	requires	require	VERB
afs-72863	263	16	either	either	DET
afs-72863	263	17	optimization	optimization	NOUN
afs-72863	263	18	of	of	ADP
afs-72863	263	19	growth	growth	NOUN
afs-72863	263	20	or	or	CCONJ
afs-72863	263	21	use	use	NOUN
afs-72863	263	22	of	of	ADP
afs-72863	263	23	immobilized	immobilized	ADJ
afs-72863	263	24	cell	cell	NOUN
afs-72863	263	25	systems	system	NOUN
afs-72863	263	26	.	.	PUNCT
afs-72863	264	1	intracellular	intracellular	ADJ
afs-72863	264	2	protein	protein	NOUN
afs-72863	264	3	production	production	NOUN
afs-72863	264	4	with	with	ADP
afs-72863	264	5	the	the	DET
afs-72863	264	6	slpa	slpa	ADJ
afs-72863	264	7	signals	signal	NOUN
afs-72863	264	8	to	to	PART
afs-72863	264	9	analyse	analyse	VERB
afs-72863	264	10	the	the	DET
afs-72863	264	11	utility	utility	NOUN
afs-72863	264	12	of	of	ADP
afs-72863	264	13	the	the	DET
afs-72863	264	14	slpa	slpa	ADJ
afs-72863	264	15	promoters	promoter	NOUN
afs-72863	264	16	for	for	ADP
afs-72863	264	17	intracellular	intracellular	ADJ
afs-72863	264	18	protein	protein	NOUN
afs-72863	264	19	production	production	NOUN
afs-72863	264	20	,	,	PUNCT
afs-72863	264	21	we	we	PRON
afs-72863	264	22	constructed	construct	VERB
afs-72863	264	23	three	three	NUM
afs-72863	264	24	reporter	reporter	NOUN
afs-72863	264	25	gene	gene	NOUN
afs-72863	264	26	cassettes	cassette	NOUN
afs-72863	264	27	,	,	PUNCT
afs-72863	264	28	6	6	NUM
afs-72863	264	29	-	-	PUNCT
afs-72863	264	30	glucuronidase	glucuronidase	NOUN
afs-72863	264	31	(	(	PUNCT
afs-72863	264	32	gusa	gusa	NOUN
afs-72863	264	33	)	)	PUNCT
afs-72863	264	34	,	,	PUNCT
afs-72863	264	35	luciferase	luciferase	INTJ
afs-72863	264	36	(	(	PUNCT
afs-72863	264	37	luc	luc	PROPN
afs-72863	264	38	)	)	PUNCT
afs-72863	264	39	and	and	CCONJ
afs-72863	264	40	aminopeptidase	aminopeptidase	NOUN
afs-72863	264	41	n	n	PROPN
afs-72863	264	42	(	(	PUNCT
afs-72863	264	43	pepn	pepn	PROPN
afs-72863	264	44	)	)	PUNCT
afs-72863	264	45	,	,	PUNCT
afs-72863	264	46	in	in	ADP
afs-72863	264	47	the	the	DET
afs-72863	264	48	pkth2o9s	pkth2o9s	PROPN
afs-72863	264	49	based	base	VERB
afs-72863	264	50	vector	vector	NOUN
afs-72863	264	51	under	under	ADP
afs-72863	264	52	the	the	DET
afs-72863	264	53	slpa	slpa	ADJ
afs-72863	264	54	pi	pi	NOUN
afs-72863	264	55	and	and	CCONJ
afs-72863	264	56	p	p	NOUN
afs-72863	264	57	2	2	NUM
afs-72863	264	58	promoters	promoter	NOUN
afs-72863	264	59	(	(	PUNCT
afs-72863	264	60	fig	fig	NOUN
afs-72863	264	61	.	.	PUNCT
afs-72863	265	1	2b	2b	NUM
afs-72863	265	2	)	)	PUNCT
afs-72863	266	1	(	(	PUNCT
afs-72863	266	2	kahala	kahala	NOUN
afs-72863	266	3	and	and	CCONJ
afs-72863	266	4	palva	palva	NOUN
afs-72863	266	5	1998	1998	NUM
afs-72863	266	6	)	)	PUNCT
afs-72863	266	7	.	.	PUNCT
afs-72863	267	1	the	the	DET
afs-72863	267	2	expression	expression	NOUN
afs-72863	267	3	of	of	ADP
afs-72863	267	4	reporters	reporter	NOUN
afs-72863	267	5	was	be	AUX
afs-72863	267	6	studied	study	VERB
afs-72863	267	7	in	in	ADP
afs-72863	267	8	three	three	NUM
afs-72863	267	9	different	different	ADJ
afs-72863	267	10	lactic	lactic	ADJ
afs-72863	267	11	acid	acid	NOUN
afs-72863	267	12	bacteria	bacteria	NOUN
afs-72863	267	13	hosts	host	NOUN
afs-72863	267	14	,	,	PUNCT
afs-72863	267	15	l.	l.	PROPN
afs-72863	267	16	lactis	lactis	PROPN
afs-72863	267	17	,	,	PUNCT
afs-72863	267	18	l.	l.	PROPN
afs-72863	267	19	plantarum	plantarum	PROPN
afs-72863	267	20	and	and	CCONJ
afs-72863	267	21	l.	l.	PROPN
afs-72863	267	22	gasseri	gasseri	PROPN
afs-72863	267	23	,	,	PUNCT
afs-72863	267	24	as	as	ADP
afs-72863	267	25	a	a	DET
afs-72863	267	26	function	function	NOUN
afs-72863	267	27	of	of	ADP
afs-72863	267	28	growth	growth	NOUN
afs-72863	267	29	.	.	PUNCT
afs-72863	268	1	the	the	DET
afs-72863	268	2	slpa	slpa	ADJ
afs-72863	268	3	promoters	promoter	NOUN
afs-72863	268	4	were	be	AUX
afs-72863	268	5	identified	identify	VERB
afs-72863	268	6	in	in	ADP
afs-72863	268	7	each	each	DET
afs-72863	268	8	strainbut	strainbut	NOUN
afs-72863	268	9	significant	significant	ADJ
afs-72863	268	10	variations	variation	NOUN
afs-72863	268	11	in	in	ADP
afs-72863	268	12	gusa	gusa	PROPN
afs-72863	268	13	,	,	PUNCT
afs-72863	268	14	luc	luc	PROPN
afs-72863	268	15	and	and	CCONJ
afs-72863	268	16	pepn	pepn	PROPN
afs-72863	268	17	activities	activity	NOUN
afs-72863	268	18	at	at	ADP
afs-72863	268	19	both	both	CCONJ
afs-72863	268	20	transcriptional	transcriptional	ADJ
afs-72863	268	21	and	and	CCONJ
afs-72863	268	22	product	product	NOUN
afs-72863	268	23	yield	yield	NOUN
afs-72863	268	24	levels	level	NOUN
afs-72863	268	25	were	be	AUX
afs-72863	268	26	evident	evident	ADJ
afs-72863	268	27	in	in	ADP
afs-72863	268	28	the	the	DET
afs-72863	268	29	different	different	ADJ
afs-72863	268	30	strains	strain	NOUN
afs-72863	268	31	.	.	PUNCT
afs-72863	269	1	the	the	DET
afs-72863	269	2	highest	high	ADJ
afs-72863	269	3	levels	level	NOUN
afs-72863	269	4	of	of	ADP
afs-72863	269	5	gusa	gusa	NOUN
afs-72863	269	6	and	and	CCONJ
afs-72863	269	7	luc	luc	PROPN
afs-72863	269	8	activities	activity	NOUN
afs-72863	269	9	were	be	AUX
afs-72863	269	10	obtained	obtain	VERB
afs-72863	269	11	in	in	ADP
afs-72863	269	12	l.	l.	PROPN
afs-72863	269	13	lactis	lactis	PROPN
afs-72863	269	14	,	,	PUNCT
afs-72863	269	15	which	which	PRON
afs-72863	269	16	produced	produce	VERB
afs-72863	269	17	,	,	PUNCT
afs-72863	269	18	for	for	ADP
afs-72863	269	19	example	example	NOUN
afs-72863	269	20	,	,	PUNCT
afs-72863	269	21	gusa	gusa	VERB
afs-72863	269	22	up	up	ADP
afs-72863	269	23	to	to	PART
afs-72863	269	24	15	15	NUM
afs-72863	269	25	%	%	NOUN
afs-72863	269	26	of	of	ADP
afs-72863	269	27	total	total	ADJ
afs-72863	269	28	cellular	cellular	ADJ
afs-72863	269	29	proteins	protein	NOUN
afs-72863	269	30	.	.	PUNCT
afs-72863	270	1	the	the	DET
afs-72863	270	2	highest	high	ADJ
afs-72863	270	3	level	level	NOUN
afs-72863	270	4	of	of	ADP
afs-72863	270	5	pepn	pepn	NOUN
afs-72863	270	6	activity	activity	NOUN
afs-72863	270	7	,	,	PUNCT
afs-72863	270	8	28	28	NUM
afs-72863	270	9	%	%	NOUN
afs-72863	270	10	of	of	ADP
afs-72863	270	11	total	total	ADJ
afs-72863	270	12	cellular	cellular	ADJ
afs-72863	270	13	proteins	protein	NOUN
afs-72863	270	14	,	,	PUNCT
afs-72863	270	15	was	be	AUX
afs-72863	270	16	achieved	achieve	VERB
afs-72863	270	17	in	in	ADP
afs-72863	270	18	l.	l.	PROPN
afs-72863	270	19	plantarum	plantarum	PROPN
afs-72863	270	20	(	(	PUNCT
afs-72863	270	21	kahala	kahala	NOUN
afs-72863	270	22	and	and	CCONJ
afs-72863	270	23	palva	palva	NOUN
afs-72863	270	24	1998	1998	NUM
afs-72863	270	25	)	)	PUNCT
afs-72863	270	26	.	.	PUNCT
afs-72863	271	1	the	the	DET
afs-72863	271	2	slpa	slpa	ADJ
afs-72863	271	3	promoters	promoter	NOUN
afs-72863	271	4	thus	thus	ADV
afs-72863	271	5	have	have	VERB
afs-72863	271	6	significant	significant	ADJ
afs-72863	271	7	potential	potential	NOUN
afs-72863	271	8	for	for	ADP
afs-72863	271	9	future	future	ADJ
afs-72863	271	10	use	use	NOUN
afs-72863	271	11	in	in	ADP
afs-72863	271	12	protein	protein	NOUN
afs-72863	271	13	production	production	NOUN
afs-72863	271	14	in	in	ADP
afs-72863	271	15	different	different	ADJ
afs-72863	271	16	lab	lab	NOUN
afs-72863	271	17	.	.	PUNCT
afs-72863	272	1	the	the	DET
afs-72863	272	2	utility	utility	NOUN
afs-72863	272	3	of	of	ADP
afs-72863	272	4	the	the	DET
afs-72863	272	5	slpa	slpa	ADJ
afs-72863	272	6	signals	signal	NOUN
afs-72863	272	7	,	,	PUNCT
afs-72863	272	8	is	be	AUX
afs-72863	272	9	,	,	PUNCT
afs-72863	272	10	however	however	ADV
afs-72863	272	11	,	,	PUNCT
afs-72863	272	12	strain	strain	NOUN
afs-72863	272	13	and	and	CCONJ
afs-72863	272	14	production	production	NOUN
afs-72863	272	15	gene	gene	NOUN
afs-72863	272	16	dependent	dependent	ADJ
afs-72863	272	17	and	and	CCONJ
afs-72863	272	18	must	must	AUX
afs-72863	272	19	be	be	AUX
afs-72863	272	20	tested	test	VERB
afs-72863	272	21	separately	separately	ADV
afs-72863	272	22	for	for	ADP
afs-72863	272	23	each	each	DET
afs-72863	272	24	gene	gene	NOUN
afs-72863	272	25	and	and	CCONJ
afs-72863	272	26	host	host	NOUN
afs-72863	272	27	of	of	ADP
afs-72863	272	28	interest	interest	NOUN
afs-72863	272	29	.	.	PUNCT
afs-72863	273	1	fig	fig	NOUN
afs-72863	273	2	.	.	PUNCT
afs-72863	274	1	3	3	X
afs-72863	274	2	.	.	X
afs-72863	274	3	secretion	secretion	NOUN
afs-72863	274	4	of	of	ADP
afs-72863	274	5	6	6	NUM
afs-72863	274	6	-	-	PUNCT
afs-72863	274	7	lactamase	lactamase	NOUN
afs-72863	274	8	under	under	ADP
afs-72863	274	9	ph	ph	ADJ
afs-72863	274	10	control	control	NOUN
afs-72863	274	11	in	in	ADP
afs-72863	274	12	l.	l.	PROPN
afs-72863	274	13	lactis	lactis	PROPN
afs-72863	274	14	mg1614	mg1614	PROPN
afs-72863	274	15	carrying	carry	VERB
afs-72863	274	16	the	the	DET
afs-72863	274	17	pktk2i2i	pktk2i2i	ADJ
afs-72863	274	18	secretion	secretion	NOUN
afs-72863	274	19	vector	vector	NOUN
afs-72863	274	20	.	.	PUNCT
afs-72863	275	1	closed	closed	ADJ
afs-72863	275	2	and	and	CCONJ
afs-72863	275	3	open	open	ADJ
afs-72863	275	4	circles	circle	NOUN
afs-72863	275	5	show	show	VERB
afs-72863	275	6	the	the	DET
afs-72863	275	7	bla	bla	NOUN
afs-72863	275	8	activities	activity	NOUN
afs-72863	275	9	and	and	CCONJ
afs-72863	275	10	cell	cell	NOUN
afs-72863	275	11	densities	density	NOUN
afs-72863	275	12	as	as	ADP
afs-72863	275	13	a	a	DET
afs-72863	275	14	function	function	NOUN
afs-72863	275	15	of	of	ADP
afs-72863	275	16	time	time	NOUN
afs-72863	275	17	.	.	PUNCT
afs-72863	276	1	cells	cell	NOUN
afs-72863	276	2	were	be	AUX
afs-72863	276	3	grown	grow	VERB
afs-72863	276	4	in	in	ADP
afs-72863	276	5	double	double	ADJ
afs-72863	276	6	strength	strength	NOUN
afs-72863	276	7	m	m	PROPN
afs-72863	276	8	l	l	NOUN
afs-72863	276	9	7	7	NUM
afs-72863	276	10	media	medium	NOUN
afs-72863	276	11	containing	contain	VERB
afs-72863	276	12	2%glucose	2%glucose	PROPN
afs-72863	276	13	(	(	PUNCT
afs-72863	276	14	2xm	2xm	ADJ
afs-72863	276	15	17	17	NUM
afs-72863	276	16	g	g	NOUN
afs-72863	276	17	)	)	PUNCT
afs-72863	276	18	and	and	CCONJ
afs-72863	276	19	in	in	ADP
afs-72863	276	20	mrs	mrs	PROPN
afs-72863	276	21	broth	broth	NOUN
afs-72863	276	22	.	.	PUNCT
afs-72863	277	1	propagation	propagation	NOUN
afs-72863	277	2	was	be	AUX
afs-72863	277	3	at	at	ADP
afs-72863	277	4	30	30	NUM
afs-72863	277	5	°	°	ADP
afs-72863	277	6	c	c	NOUN
afs-72863	277	7	in	in	ADP
afs-72863	277	8	a	a	DET
afs-72863	277	9	bioreactor	bioreactor	NOUN
afs-72863	277	10	(	(	PUNCT
afs-72863	277	11	biostat	biostat	PROPN
afs-72863	277	12	®	®	PROPN
afs-72863	277	13	b	b	NOUN
afs-72863	277	14	,	,	PUNCT
afs-72863	277	15	medical	medical	ADJ
afs-72863	277	16	brown	brown	NOUN
afs-72863	277	17	)	)	PUNCT
afs-72863	277	18	with	with	ADP
afs-72863	277	19	gentle	gentle	ADJ
afs-72863	277	20	(	(	PUNCT
afs-72863	277	21	100	100	NUM
afs-72863	277	22	rpm	rpm	NOUN
afs-72863	277	23	)	)	PUNCT
afs-72863	277	24	stirring	stirring	NOUN
afs-72863	277	25	and	and	CCONJ
afs-72863	277	26	without	without	ADP
afs-72863	277	27	aeration	aeration	NOUN
afs-72863	277	28	.	.	PUNCT
afs-72863	278	1	glucose	glucose	NOUN
afs-72863	278	2	was	be	AUX
afs-72863	278	3	added	add	VERB
afs-72863	278	4	in	in	ADP
afs-72863	278	5	amounts	amount	NOUN
afs-72863	278	6	required	require	VERB
afs-72863	278	7	to	to	PART
afs-72863	278	8	maintain	maintain	VERB
afs-72863	278	9	the	the	DET
afs-72863	278	10	final	final	ADJ
afs-72863	278	11	concentration	concentration	NOUN
afs-72863	278	12	of	of	ADP
afs-72863	278	13	2	2	NUM
afs-72863	278	14	%	%	NOUN
afs-72863	278	15	,	,	PUNCT
afs-72863	278	16	and	and	CCONJ
afs-72863	278	17	the	the	DET
afs-72863	278	18	ph	ph	NOUN
afs-72863	278	19	of	of	ADP
afs-72863	278	20	the	the	DET
afs-72863	278	21	culture	culture	NOUN
afs-72863	278	22	was	be	AUX
afs-72863	278	23	adjusted	adjust	VERB
afs-72863	278	24	to	to	ADP
afs-72863	278	25	5.5	5.5	NUM
afs-72863	278	26	by	by	ADP
afs-72863	278	27	1	1	NUM
afs-72863	278	28	n	n	PROPN
afs-72863	278	29	nh	nh	NOUN
afs-72863	278	30	3	3	NUM
afs-72863	278	31	samples	sample	NOUN
afs-72863	278	32	were	be	AUX
afs-72863	278	33	taken	take	VERB
afs-72863	278	34	at	at	ADP
afs-72863	278	35	different	different	ADJ
afs-72863	278	36	times	time	NOUN
afs-72863	278	37	up	up	ADP
afs-72863	278	38	to	to	PART
afs-72863	278	39	22	22	NUM
afs-72863	278	40	h	h	NOUN
afs-72863	278	41	,	,	PUNCT
afs-72863	278	42	and	and	CCONJ
afs-72863	278	43	the	the	DET
afs-72863	278	44	supernatant	supernatant	NOUN
afs-72863	278	45	fractions	fraction	NOUN
afs-72863	278	46	were	be	AUX
afs-72863	278	47	analysed	analyse	VERB
afs-72863	278	48	.	.	PUNCT
afs-72863	279	1	278	278	NUM
afs-72863	279	2	seminar	seminar	NOUN
afs-72863	279	3	in	in	ADP
afs-72863	279	4	honour	honour	NOUN
afs-72863	279	5	of	of	ADP
afs-72863	279	6	the	the	DET
afs-72863	279	7	100thanniversary	100thanniversary	PROPN
afs-72863	279	8	ofmtt	ofmtt	VERB
afs-72863	279	9	agricultural	agricultural	ADJ
afs-72863	279	10	and	and	CCONJ
afs-72863	279	11	food	food	NOUN
afs-72863	279	12	science	science	NOUN
afs-72863	279	13	in	in	ADP
afs-72863	279	14	finland	finland	PROPN
afs-72863	279	15	in	in	ADP
afs-72863	279	16	the	the	DET
afs-72863	279	17	light	light	NOUN
afs-72863	279	18	of	of	ADP
afs-72863	279	19	present	present	ADJ
afs-72863	279	20	knowledge	knowledge	NOUN
afs-72863	279	21	,	,	PUNCT
afs-72863	279	22	we	we	PRON
afs-72863	279	23	can	can	AUX
afs-72863	279	24	expect	expect	VERB
afs-72863	279	25	that	that	SCONJ
afs-72863	279	26	lactobacillar	lactobacillar	ADJ
afs-72863	279	27	s	s	NOUN
afs-72863	279	28	-	-	NOUN
afs-72863	279	29	layers	layer	NOUN
afs-72863	279	30	will	will	AUX
afs-72863	279	31	be	be	AUX
afs-72863	279	32	further	far	ADV
afs-72863	279	33	developed	develop	VERB
afs-72863	279	34	for	for	ADP
afs-72863	279	35	different	different	ADJ
afs-72863	279	36	biotechnological	biotechnological	ADJ
afs-72863	279	37	applications	application	NOUN
afs-72863	279	38	.	.	PUNCT
afs-72863	280	1	one	one	NUM
afs-72863	280	2	obvions	obvion	NOUN
afs-72863	280	3	application	application	NOUN
afs-72863	280	4	of	of	ADP
afs-72863	280	5	thel	thel	PROPN
afs-72863	280	6	.	.	PUNCT
afs-72863	281	1	brevis	brevis	PROPN
afs-72863	281	2	s	s	NOUN
afs-72863	281	3	-	-	NOUN
afs-72863	281	4	protein	protein	NOUN
afs-72863	281	5	currently	currently	ADV
afs-72863	281	6	being	be	AUX
afs-72863	281	7	studied	study	VERB
afs-72863	281	8	is	be	AUX
afs-72863	281	9	as	as	ADP
afs-72863	281	10	a	a	DET
afs-72863	281	11	carrier	carrier	NOUN
afs-72863	281	12	vehicle	vehicle	NOUN
afs-72863	281	13	of	of	ADP
afs-72863	281	14	foreign	foreign	ADJ
afs-72863	281	15	antigenic	antigenic	ADJ
afs-72863	281	16	epitopes	epitope	NOUN
afs-72863	281	17	.	.	PUNCT
afs-72863	282	1	further	further	ADJ
afs-72863	282	2	elucidation	elucidation	NOUN
afs-72863	282	3	of	of	ADP
afs-72863	282	4	the	the	DET
afs-72863	282	5	adhesive	adhesive	ADJ
afs-72863	282	6	properties	property	NOUN
afs-72863	282	7	of	of	ADP
afs-72863	282	8	the	the	DET
afs-72863	282	9	l.	l.	PROPN
afs-72863	282	10	brevis	brevis	PROPN
afs-72863	282	11	s	s	PROPN
afs-72863	282	12	-	-	NOUN
afs-72863	282	13	protein	protein	NOUN
afs-72863	282	14	may	may	AUX
afs-72863	282	15	also	also	ADV
afs-72863	282	16	allow	allow	VERB
afs-72863	282	17	and	and	CCONJ
afs-72863	282	18	extend	extend	VERB
afs-72863	282	19	its	its	PRON
afs-72863	282	20	utilisation	utilisation	NOUN
afs-72863	282	21	as	as	ADP
afs-72863	282	22	a	a	DET
afs-72863	282	23	carrier	carrier	NOUN
afs-72863	282	24	of	of	ADP
afs-72863	282	25	oral	oral	ADJ
afs-72863	282	26	vaccines	vaccine	NOUN
afs-72863	282	27	and	and	CCONJ
afs-72863	282	28	other	other	ADJ
afs-72863	282	29	substances	substance	NOUN
afs-72863	282	30	for	for	ADP
afs-72863	282	31	animal	animal	NOUN
afs-72863	282	32	and	and	CCONJ
afs-72863	282	33	human	human	ADJ
afs-72863	282	34	use	use	NOUN
afs-72863	282	35	.	.	PUNCT
afs-72863	283	1	further	further	ADJ
afs-72863	283	2	developments	development	NOUN
afs-72863	283	3	will	will	AUX
afs-72863	283	4	include	include	VERB
afs-72863	283	5	the	the	DET
afs-72863	283	6	extension	extension	NOUN
afs-72863	283	7	of	of	ADP
afs-72863	283	8	the	the	DET
afs-72863	283	9	use	use	NOUN
afs-72863	283	10	of	of	ADP
afs-72863	283	11	the	the	DET
afs-72863	283	12	l.	l.	PROPN
afs-72863	283	13	brevis	brevis	PROPN
afs-72863	283	14	slpa	slpa	PROPN
afs-72863	283	15	signal	signal	NOUN
afs-72863	283	16	for	for	ADP
afs-72863	283	17	both	both	CCONJ
afs-72863	283	18	secretion	secretion	NOUN
afs-72863	283	19	and	and	CCONJ
afs-72863	283	20	intracellular	intracellular	ADJ
afs-72863	283	21	protein	protein	NOUN
afs-72863	283	22	production	production	NOUN
afs-72863	283	23	to	to	PART
afs-72863	283	24	improve	improve	VERB
afs-72863	283	25	fermentation	fermentation	NOUN
afs-72863	283	26	processes	process	NOUN
afs-72863	283	27	.	.	PUNCT
afs-72863	284	1	acknowledgements	acknowledgement	NOUN
afs-72863	284	2	.	.	PUNCT
afs-72863	285	1	the	the	DET
afs-72863	285	2	author	author	NOUN
afs-72863	285	3	is	be	AUX
afs-72863	285	4	grateful	grateful	ADJ
afs-72863	285	5	to	to	ADP
afs-72863	285	6	m.sc	m.sc	PROPN
afs-72863	285	7	.	.	PUNCT
afs-72863	286	1	kirsi	kirsi	PROPN
afs-72863	286	2	savijoki	savijoki	NOUN
afs-72863	286	3	and	and	CCONJ
afs-72863	286	4	m.sc	m.sc	PROPN
afs-72863	286	5	.	.	PROPN
afs-72863	286	6	minna	minna	PROPN
afs-72863	286	7	kahala	kahala	PROPN
afs-72863	286	8	for	for	ADP
afs-72863	286	9	drawing	draw	VERB
afs-72863	286	10	the	the	DET
afs-72863	286	11	figures	figure	NOUN
afs-72863	286	12	.	.	PUNCT
afs-72863	287	1	references	reference	NOUN
afs-72863	287	2	ardö	ardö	PROPN
afs-72863	287	3	,	,	PUNCT
afs-72863	287	4	y.	y.	PROPN
afs-72863	287	5	&	&	CCONJ
afs-72863	287	6	larsson	larsson	PROPN
afs-72863	287	7	,	,	PUNCT
afs-72863	287	8	p.	p.	NOUN
afs-72863	287	9	1989	1989	NUM
afs-72863	287	10	.	.	PUNCT
afs-72863	288	1	studies	study	NOUN
afs-72863	288	2	of	of	ADP
afs-72863	288	3	peptidolysis	peptidolysis	NOUN
afs-72863	288	4	during	during	ADP
afs-72863	288	5	early	early	ADJ
afs-72863	288	6	maturation	maturation	NOUN
afs-72863	288	7	and	and	CCONJ
afs-72863	288	8	its	its	PRON
afs-72863	288	9	influence	influence	NOUN
afs-72863	288	10	on	on	ADP
afs-72863	288	11	low	low	ADJ
afs-72863	288	12	-	-	PUNCT
afs-72863	288	13	fat	fat	ADJ
afs-72863	288	14	cheese	cheese	NOUN
afs-72863	288	15	quality	quality	NOUN
afs-72863	288	16	.	.	PUNCT
afs-72863	289	1	milchwissenschafl	milchwissenschafl	NOUN
afs-72863	289	2	44	44	NUM
afs-72863	289	3	:	:	PUNCT
afs-72863	289	4	485	485	NUM
afs-72863	289	5	-	-	SYM
afs-72863	289	6	490	490	NUM
afs-72863	289	7	.	.	PUNCT
afs-72863	289	8	allan	allan	PROPN
afs-72863	289	9	,	,	PUNCT
afs-72863	289	10	d.	d.	PROPN
afs-72863	289	11	,	,	PUNCT
afs-72863	289	12	gilbert	gilbert	PROPN
afs-72863	289	13	,	,	PUNCT
afs-72863	289	14	c.	c.	PROPN
afs-72863	289	15	,	,	PUNCT
afs-72863	289	16	blanc	blanc	PROPN
afs-72863	289	17	,	,	PUNCT
afs-72863	289	18	b.	b.	PROPN
afs-72863	289	19	&	&	CCONJ
afs-72863	289	20	portalier	portalier	PROPN
afs-72863	289	21	,	,	PUNCT
afs-72863	289	22	r.	r.	PROPN
afs-72863	289	23	1994	1994	NUM
afs-72863	289	24	.	.	PUNCT
afs-72863	290	1	cloning	cloning	NOUN
afs-72863	290	2	,	,	PUNCT
afs-72863	290	3	sequencing	sequencing	NOUN
afs-72863	290	4	and	and	CCONJ
afs-72863	290	5	characterization	characterization	NOUN
afs-72863	290	6	of	of	ADP
afs-72863	290	7	the	the	DET
afs-72863	290	8	peplp	peplp	ADJ
afs-72863	290	9	gene	gene	NOUN
afs-72863	290	10	encoding	encode	VERB
afs-72863	290	11	a	a	DET
afs-72863	290	12	proline	proline	NOUN
afs-72863	290	13	iminopeptidase	iminopeptidase	NOUN
afs-72863	290	14	from	from	ADP
afs-72863	290	15	lactobacillus	lactobacillus	NOUN
afs-72863	290	16	delbrueckii	delbrueckii	PROPN
afs-72863	290	17	subsp	subsp	NOUN
afs-72863	290	18	.	.	PUNCT
afs-72863	291	1	bulgaricus	bulgaricus	NOUN
afs-72863	291	2	cnrz	cnrz	ADJ
afs-72863	291	3	397	397	NUM
afs-72863	291	4	.	.	PUNCT
afs-72863	292	1	microbiology	microbiology	NOUN
afs-72863	292	2	140	140	NUM
afs-72863	292	3	:	:	PUNCT
afs-72863	292	4	527	527	NUM
afs-72863	292	5	-	-	SYM
afs-72863	292	6	535	535	NUM
afs-72863	292	7	.	.	PUNCT
afs-72863	293	1	baankreis	baankreis	PROPN
afs-72863	293	2	,	,	PUNCT
afs-72863	293	3	r.	r.	PROPN
afs-72863	293	4	&	&	CCONJ
afs-72863	293	5	exterkate	exterkate	PROPN
afs-72863	293	6	,	,	PUNCT
afs-72863	293	7	f.	f.	PROPN
afs-72863	293	8	1991	1991	NUM
afs-72863	293	9	.	.	PUNCT
afs-72863	294	1	characterization	characterization	NOUN
afs-72863	294	2	of	of	ADP
afs-72863	294	3	a	a	DET
afs-72863	294	4	peptidase	peptidase	NOUN
afs-72863	294	5	from	from	ADP
afs-72863	294	6	lactococcus	lactococcus	PROPN
afs-72863	294	7	lactis	lactis	PROPN
afs-72863	294	8	ssp	ssp	PROPN
afs-72863	294	9	.	.	PUNCT
afs-72863	295	1	cremoris	cremoris	PROPN
afs-72863	295	2	hp	hp	PROPN
afs-72863	295	3	that	that	PRON
afs-72863	295	4	hydrolyses	hydrolyse	VERB
afs-72863	295	5	diand	diand	NOUN
afs-72863	295	6	tripeptides	tripeptide	VERB
afs-72863	295	7	containing	contain	VERB
afs-72863	295	8	proline	proline	NOUN
afs-72863	295	9	or	or	CCONJ
afs-72863	295	10	hydrophobic	hydrophobic	NOUN
afs-72863	295	11	residues	residue	NOUN
afs-72863	295	12	as	as	ADP
afs-72863	295	13	the	the	DET
afs-72863	295	14	aminoterminal	aminoterminal	ADJ
afs-72863	295	15	amino	amino	NOUN
afs-72863	295	16	acid	acid	NOUN
afs-72863	295	17	.	.	PUNCT
afs-72863	296	1	systematic	systematic	ADJ
afs-72863	296	2	and	and	CCONJ
afs-72863	296	3	applied	apply	VERB
afs-72863	296	4	microbiology	microbiology	NOUN
afs-72863	296	5	14	14	NUM
afs-72863	296	6	:	:	PUNCT
afs-72863	296	7	317	317	NUM
afs-72863	296	8	-	-	SYM
afs-72863	296	9	323	323	NUM
afs-72863	296	10	.	.	PUNCT
afs-72863	297	1	bartels	bartels	PROPN
afs-72863	297	2	,	,	PUNCT
afs-72863	297	3	h.	h.	PROPN
afs-72863	297	4	,	,	PUNCT
afs-72863	297	5	johnson	johnson	PROPN
afs-72863	297	6	,	,	PUNCT
afs-72863	297	7	m.	m.	NOUN
afs-72863	297	8	&	&	CCONJ
afs-72863	297	9	olson	olson	PROPN
afs-72863	297	10	,	,	PUNCT
afs-72863	297	11	n.	n.	NOUN
afs-72863	297	12	1987a	1987a	NUM
afs-72863	297	13	.	.	PUNCT
afs-72863	298	1	accelerated	accelerate	VERB
afs-72863	298	2	ripening	ripening	NOUN
afs-72863	298	3	of	of	ADP
afs-72863	298	4	gouda	gouda	NOUN
afs-72863	298	5	cheese	cheese	NOUN
afs-72863	298	6	.	.	PUNCT
afs-72863	299	1	1	1	NUM
afs-72863	299	2	,	,	PUNCT
afs-72863	299	3	effect	effect	NOUN
afs-72863	299	4	of	of	ADP
afs-72863	299	5	heat	heat	NOUN
afs-72863	299	6	-	-	PUNCT
afs-72863	299	7	shocked	shock	VERB
afs-72863	299	8	thermophilic	thermophilic	ADJ
afs-72863	299	9	lactobacilli	lactobacilli	NOUN
afs-72863	299	10	and	and	CCONJ
afs-72863	299	11	streptococci	streptococci	NOUN
afs-72863	299	12	on	on	ADP
afs-72863	299	13	proteolysis	proteolysis	NOUN
afs-72863	299	14	and	and	CCONJ
afs-72863	299	15	flavor	flavor	NOUN
afs-72863	299	16	development	development	NOUN
afs-72863	299	17	.	.	PUNCT
afs-72863	300	1	milchwissenschafl	milchwissenschafl	VERB
afs-72863	300	2	42	42	NUM
afs-72863	300	3	:	:	PUNCT
afs-72863	300	4	83	83	NUM
afs-72863	300	5	-	-	SYM
afs-72863	300	6	88	88	NUM
afs-72863	300	7	,	,	PUNCT
afs-72863	300	8	,	,	PUNCT
afs-72863	300	9	johnson	johnson	PROPN
afs-72863	300	10	,	,	PUNCT
afs-72863	300	11	m.	m.	NOUN
afs-72863	300	12	&	&	CCONJ
afs-72863	300	13	olson	olson	PROPN
afs-72863	300	14	,	,	PUNCT
afs-72863	300	15	n.	n.	PROPN
afs-72863	300	16	1987b	1987b	PROPN
afs-72863	300	17	.	.	PUNCT
afs-72863	301	1	accelerated	accelerate	VERB
afs-72863	301	2	ripening	ripening	NOUN
afs-72863	301	3	of	of	ADP
afs-72863	301	4	gouda	gouda	NOUN
afs-72863	301	5	cheese	cheese	NOUN
afs-72863	301	6	.	.	PUNCT
afs-72863	302	1	2	2	X
afs-72863	302	2	.	.	X
afs-72863	302	3	effect	effect	NOUN
afs-72863	302	4	of	of	ADP
afs-72863	302	5	freeze	freeze	NOUN
afs-72863	302	6	-	-	PUNCT
afs-72863	302	7	shocked	shock	VERB
afs-72863	302	8	lactobacillus	lactobacillus	NOUN
afs-72863	302	9	helveticus	helveticus	NOUN
afs-72863	302	10	on	on	ADP
afs-72863	302	11	proteolysis	proteolysis	NOUN
afs-72863	302	12	and	and	CCONJ
afs-72863	302	13	flavor	flavor	NOUN
afs-72863	302	14	development	development	NOUN
afs-72863	302	15	.	.	PUNCT
afs-72863	303	1	milchwissenschafl	milchwissenschafl	VERB
afs-72863	303	2	42	42	NUM
afs-72863	303	3	:	:	PUNCT
afs-72863	303	4	139	139	NUM
afs-72863	303	5	-	-	SYM
afs-72863	303	6	144	144	NUM
afs-72863	303	7	.	.	PUNCT
afs-72863	304	1	biede	biede	PROPN
afs-72863	304	2	,	,	PUNCT
afs-72863	304	3	s.l	s.l	PROPN
afs-72863	304	4	.	.	PROPN
afs-72863	304	5	&	&	CCONJ
afs-72863	304	6	hammond	hammond	PROPN
afs-72863	304	7	,	,	PUNCT
afs-72863	304	8	e.g.	e.g.	ADV
afs-72863	304	9	1979	1979	NUM
afs-72863	304	10	.	.	PUNCT
afs-72863	305	1	swiss	swiss	ADJ
afs-72863	305	2	cheese	cheese	NOUN
afs-72863	305	3	flavor	flavor	NOUN
afs-72863	305	4	.	.	PUNCT
afs-72863	306	1	1	1	X
afs-72863	306	2	.	.	X
afs-72863	306	3	chemical	chemical	ADJ
afs-72863	306	4	analysis	analysis	NOUN
afs-72863	306	5	.	.	PUNCT
afs-72863	307	1	journal	journal	NOUN
afs-72863	307	2	of	of	ADP
afs-72863	307	3	dairy	dairy	NOUN
afs-72863	307	4	science	science	NOUN
afs-72863	307	5	62	62	NUM
afs-72863	307	6	:	:	PUNCT
afs-72863	307	7	227	227	NUM
afs-72863	307	8	-	-	SYM
afs-72863	307	9	237	237	NUM
afs-72863	307	10	.	.	PUNCT
afs-72863	308	1	boot	boot	NOUN
afs-72863	308	2	,	,	PUNCT
afs-72863	308	3	h.j	h.j	PROPN
afs-72863	308	4	.	.	PROPN
afs-72863	308	5	1996	1996	NUM
afs-72863	308	6	.	.	PUNCT
afs-72863	309	1	the	the	DET
afs-72863	309	2	surface	surface	NOUN
afs-72863	309	3	layerprotein	layerprotein	NOUN
afs-72863	309	4	genes	gene	NOUN
afs-72863	309	5	oflactobacillus	oflactobacillus	CCONJ
afs-72863	309	6	acidophilus	acidophilus	X
afs-72863	309	7	.	.	PUNCT
afs-72863	310	1	academic	academic	ADJ
afs-72863	310	2	thesis	thesis	NOUN
afs-72863	310	3	.	.	PUNCT
afs-72863	311	1	faculties	faculty	NOUN
afs-72863	311	2	of	of	ADP
afs-72863	311	3	biology	biology	NOUN
afs-72863	311	4	and	and	CCONJ
afs-72863	311	5	chemistry	chemistry	NOUN
afs-72863	311	6	of	of	ADP
afs-72863	311	7	university	university	NOUN
afs-72863	311	8	of	of	ADP
afs-72863	311	9	amsterdam	amsterdam	PROPN
afs-72863	311	10	.	.	PUNCT
afs-72863	312	1	the	the	DET
afs-72863	312	2	netherlands	netherlands	PROPN
afs-72863	312	3	.	.	PUNCT
afs-72863	312	4	,	,	PUNCT
afs-72863	312	5	kolen	kolen	PROPN
afs-72863	312	6	,	,	PUNCT
afs-72863	312	7	c.p.a.m	c.p.a.m	PROPN
afs-72863	312	8	.	.	PROPN
afs-72863	312	9	,	,	PUNCT
afs-72863	312	10	andreadaki	andreadaki	INTJ
afs-72863	312	11	,	,	PUNCT
afs-72863	312	12	f.j	f.j	PROPN
afs-72863	312	13	.	.	PROPN
afs-72863	312	14	,	,	PUNCT
afs-72863	312	15	leer	leer	PROPN
afs-72863	312	16	,	,	PUNCT
afs-72863	312	17	r.j	r.j	PROPN
afs-72863	312	18	.	.	PROPN
afs-72863	312	19	&	&	CCONJ
afs-72863	312	20	pouwels	pouwels	PROPN
afs-72863	312	21	p.h	p.h	PROPN
afs-72863	312	22	.	.	PROPN
afs-72863	312	23	1996	1996	NUM
afs-72863	312	24	.	.	PUNCT
afs-72863	313	1	the	the	DET
afs-72863	313	2	lactobacillus	lactobacillus	NOUN
afs-72863	313	3	acidophiluss	acidophiluss	ADJ
afs-72863	313	4	-	-	ADJ
afs-72863	313	5	protein	protein	NOUN
afs-72863	313	6	gene	gene	NOUN
afs-72863	313	7	expression	expression	NOUN
afs-72863	313	8	site	site	NOUN
afs-72863	313	9	comprises	comprise	VERB
afs-72863	313	10	two	two	NUM
afs-72863	313	11	consensus	consensus	NOUN
afs-72863	313	12	promoter	promoter	NOUN
afs-72863	313	13	sequences	sequence	NOUN
afs-72863	313	14	one	one	NUM
afs-72863	313	15	of	of	ADP
afs-72863	313	16	which	which	PRON
afs-72863	313	17	directs	direct	VERB
afs-72863	313	18	transcription	transcription	NOUN
afs-72863	313	19	of	of	ADP
afs-72863	313	20	stable	stable	ADJ
afs-72863	313	21	mrna	mrna	PROPN
afs-72863	313	22	.	.	PUNCT
afs-72863	314	1	journal	journal	PROPN
afs-72863	314	2	of	of	ADP
afs-72863	314	3	bacteriology	bacteriology	NOUN
afs-72863	314	4	78	78	NUM
afs-72863	314	5	:	:	PUNCT
afs-72863	314	6	5388	5388	NUM
afs-72863	314	7	-	-	SYM
afs-72863	314	8	5394	5394	NUM
afs-72863	314	9	.	.	PUNCT
afs-72863	314	10	,	,	PUNCT
afs-72863	315	1	kolen	kolen	PROPN
afs-72863	315	2	,	,	PUNCT
afs-72863	315	3	c.p.a.m	c.p.a.m	PROPN
afs-72863	315	4	.	.	PROPN
afs-72863	315	5	,	,	PUNCT
afs-72863	315	6	van	van	PROPN
afs-72863	315	7	noort	noort	NOUN
afs-72863	315	8	,	,	PUNCT
afs-72863	315	9	j.m	j.m	PROPN
afs-72863	315	10	.	.	PROPN
afs-72863	315	11	&	&	CCONJ
afs-72863	315	12	pouwels	pouwels	PROPN
afs-72863	315	13	,	,	PUNCT
afs-72863	315	14	p.h	p.h	PROPN
afs-72863	315	15	.	.	PROPN
afs-72863	315	16	1993	1993	NUM
afs-72863	315	17	.	.	PUNCT
afs-72863	316	1	s	s	X
afs-72863	316	2	-	-	PUNCT
afs-72863	316	3	layer	layer	NOUN
afs-72863	316	4	protein	protein	NOUN
afs-72863	316	5	of	of	ADP
afs-72863	316	6	lactobacillus	lactobacillus	NOUN
afs-72863	316	7	acidophilus	acidophilus	NOUN
afs-72863	316	8	atcc	atcc	NOUN
afs-72863	316	9	4356	4356	NUM
afs-72863	316	10	:	:	PUNCT
afs-72863	316	11	purification	purification	NOUN
afs-72863	316	12	,	,	PUNCT
afs-72863	316	13	expression	expression	NOUN
afs-72863	316	14	in	in	ADP
afs-72863	316	15	escherichia	escherichia	NOUN
afs-72863	316	16	coli	coli	NOUN
afs-72863	316	17	,	,	PUNCT
afs-72863	316	18	and	and	CCONJ
afs-72863	316	19	nucleotide	nucleotide	ADJ
afs-72863	316	20	sequence	sequence	NOUN
afs-72863	316	21	of	of	ADP
afs-72863	316	22	the	the	DET
afs-72863	316	23	corresponding	corresponding	ADJ
afs-72863	316	24	gene	gene	NOUN
afs-72863	316	25	.	.	PUNCT
afs-72863	317	1	journal	journal	PROPN
afs-72863	317	2	of	of	ADP
afs-72863	317	3	bacteriology	bacteriology	NOUN
afs-72863	317	4	175	175	NUM
afs-72863	317	5	:	:	PUNCT
afs-72863	317	6	6089	6089	NUM
afs-72863	317	7	-	-	SYM
afs-72863	317	8	6096	6096	NUM
afs-72863	317	9	.	.	PUNCT
afs-72863	318	1	breitwieser	breitwieser	NOUN
afs-72863	318	2	,	,	PUNCT
afs-72863	318	3	a.	a.	PROPN
afs-72863	318	4	,	,	PUNCT
afs-72863	318	5	gruber	gruber	PROPN
afs-72863	318	6	,	,	PUNCT
afs-72863	318	7	k.	k.	PROPN
afs-72863	318	8	&	&	CCONJ
afs-72863	318	9	sleytr	sleytr	PROPN
afs-72863	318	10	,	,	PUNCT
afs-72863	318	11	u.b	u.b	PROPN
afs-72863	318	12	.	.	PROPN
afs-72863	318	13	1992	1992	NUM
afs-72863	318	14	.	.	PUNCT
afs-72863	319	1	evidence	evidence	NOUN
afs-72863	319	2	for	for	ADP
afs-72863	319	3	an	an	DET
afs-72863	319	4	s	s	NOUN
afs-72863	319	5	-	-	PUNCT
afs-72863	319	6	layer	layer	NOUN
afs-72863	319	7	protein	protein	NOUN
afs-72863	319	8	pool	pool	NOUN
afs-72863	319	9	in	in	ADP
afs-72863	319	10	the	the	DET
afs-72863	319	11	peptidoglycan	peptidoglycan	NOUN
afs-72863	319	12	of	of	ADP
afs-72863	319	13	bacillus	bacillus	NOUN
afs-72863	319	14	stearothermophilus	stearothermophilus	NOUN
afs-72863	319	15	.	.	PUNCT
afs-72863	320	1	journal	journal	PROPN
afs-72863	320	2	ofbacteriology	ofbacteriology	NOUN
afs-72863	320	3	174	174	NUM
afs-72863	320	4	:	:	PUNCT
afs-72863	320	5	8008	8008	NUM
afs-72863	320	6	-	-	SYM
afs-72863	320	7	8015	8015	NUM
afs-72863	320	8	.	.	PUNCT
afs-72863	321	1	chapot	chapot	NOUN
afs-72863	321	2	-	-	PUNCT
afs-72863	321	3	chartier	chartier	NOUN
afs-72863	321	4	,	,	PUNCT
afs-72863	321	5	m.-p	m.-p	PROPN
afs-72863	321	6	.	.	PROPN
afs-72863	321	7	,	,	PUNCT
afs-72863	321	8	nardi	nardi	PROPN
afs-72863	321	9	,	,	PUNCT
afs-72863	321	10	m.	m.	NOUN
afs-72863	321	11	,	,	PUNCT
afs-72863	321	12	chopin	chopin	PROPN
afs-72863	321	13	,	,	PUNCT
afs-72863	321	14	m.-c	m.-c	NOUN
afs-72863	321	15	.	.	PUNCT
afs-72863	321	16	,	,	PUNCT
afs-72863	321	17	chopin	chopin	PROPN
afs-72863	321	18	,	,	PUNCT
afs-72863	321	19	a.	a.	NOUN
afs-72863	321	20	&	&	CCONJ
afs-72863	321	21	gripon	gripon	ADV
afs-72863	321	22	,	,	PUNCT
afs-72863	321	23	j.-c	j.-c	PROPN
afs-72863	321	24	.	.	PUNCT
afs-72863	322	1	1993	1993	NUM
afs-72863	322	2	.	.	PUNCT
afs-72863	323	1	cloning	cloning	NOUN
afs-72863	323	2	and	and	CCONJ
afs-72863	323	3	sequencing	sequencing	NOUN
afs-72863	323	4	of	of	ADP
afs-72863	323	5	pepc	pepc	NOUN
afs-72863	323	6	,	,	PUNCT
afs-72863	323	7	a	a	DET
afs-72863	323	8	cysteine	cysteine	NOUN
afs-72863	323	9	aminopeptidase	aminopeptidase	NOUN
afs-72863	323	10	gene	gene	NOUN
afs-72863	323	11	from	from	ADP
afs-72863	323	12	lactococcus	lactococcus	PROPN
afs-72863	323	13	lactis	lactis	PROPN
afs-72863	323	14	subsp	subsp	NOUN
afs-72863	323	15	.	.	PUNCT
afs-72863	324	1	cremorisam2	cremorisam2	PROPN
afs-72863	324	2	.	.	PUNCT
afs-72863	325	1	applied	apply	VERB
afs-72863	325	2	and	and	CCONJ
afs-72863	325	3	environmental	environmental	ADJ
afs-72863	325	4	microbiology	microbiology	NOUN
afs-72863	325	5	59	59	NUM
afs-72863	325	6	:	:	SYM
afs-72863	325	7	330	330	NUM
afs-72863	325	8	-	-	SYM
afs-72863	325	9	333	333	NUM
afs-72863	325	10	.	.	PUNCT
afs-72863	326	1	chopin	chopin	PROPN
afs-72863	326	2	,	,	PUNCT
afs-72863	326	3	a.	a.	NOUN
afs-72863	326	4	1993	1993	NUM
afs-72863	326	5	.	.	PUNCT
afs-72863	327	1	organization	organization	NOUN
afs-72863	327	2	and	and	CCONJ
afs-72863	327	3	regulation	regulation	NOUN
afs-72863	327	4	of	of	ADP
afs-72863	327	5	genes	gene	NOUN
afs-72863	327	6	for	for	ADP
afs-72863	327	7	amino	amino	NOUN
afs-72863	327	8	acid	acid	NOUN
afs-72863	327	9	biosynthesis	biosynthesis	NOUN
afs-72863	327	10	in	in	ADP
afs-72863	327	11	lactic	lactic	ADJ
afs-72863	327	12	acid	acid	NOUN
afs-72863	327	13	bacteria	bacteria	NOUN
afs-72863	327	14	.	.	PUNCT
afs-72863	328	1	fems	fems	PROPN
afs-72863	328	2	microbiologyreviews	microbiologyreviews	VERB
afs-72863	328	3	12	12	NUM
afs-72863	328	4	:	:	SYM
afs-72863	328	5	21	21	NUM
afs-72863	328	6	-	-	SYM
afs-72863	328	7	38	38	NUM
afs-72863	328	8	.	.	PUNCT
afs-72863	329	1	christensen	christensen	PROPN
afs-72863	329	2	,	,	PUNCT
afs-72863	329	3	j.	j.	PROPN
afs-72863	329	4	,	,	PUNCT
afs-72863	329	5	lin	lin	PROPN
afs-72863	329	6	,	,	PUNCT
afs-72863	329	7	d.	d.	PROPN
afs-72863	329	8	,	,	PUNCT
afs-72863	329	9	palva	palva	NOUN
afs-72863	329	10	,	,	PUNCT
afs-72863	329	11	a.	a.	PROPN
afs-72863	329	12	&	&	CCONJ
afs-72863	329	13	steele	steele	PROPN
afs-72863	329	14	,	,	PUNCT
afs-72863	329	15	j.	j.	PROPN
afs-72863	329	16	1995	1995	NUM
afs-72863	329	17	.	.	PUNCT
afs-72863	330	1	sequence	sequence	NOUN
afs-72863	330	2	analysis	analysis	NOUN
afs-72863	330	3	,	,	PUNCT
afs-72863	330	4	distribution	distribution	NOUN
afs-72863	330	5	and	and	CCONJ
afs-72863	330	6	expression	expression	NOUN
afs-72863	330	7	of	of	ADP
afs-72863	330	8	an	an	DET
afs-72863	330	9	aminopeptidase	aminopeptidase	NOUN
afs-72863	330	10	from	from	ADP
afs-72863	330	11	lactobacillus	lactobacillus	NOUN
afs-72863	330	12	helveticus	helveticus	NOUN
afs-72863	330	13	cnrz32	cnrz32	NOUN
afs-72863	330	14	.	.	PUNCT
afs-72863	331	1	gene	gene	NOUN
afs-72863	331	2	155	155	NUM
afs-72863	331	3	:	:	SYM
afs-72863	331	4	89	89	NUM
afs-72863	331	5	-	-	SYM
afs-72863	331	6	93	93	NUM
afs-72863	331	7	.	.	PUNCT
afs-72863	332	1	chu	chu	PROPN
afs-72863	332	2	,	,	PUNCT
afs-72863	332	3	s.	s.	PROPN
afs-72863	332	4	,	,	PUNCT
afs-72863	332	5	gustafson	gustafson	PROPN
afs-72863	332	6	,	,	PUNCT
afs-72863	332	7	c.e	c.e	PROPN
afs-72863	332	8	.	.	PROPN
afs-72863	332	9	,	,	PUNCT
afs-72863	332	10	feutrier	feutrier	PROPN
afs-72863	332	11	,	,	PUNCT
afs-72863	332	12	j.	j.	PROPN
afs-72863	332	13	,	,	PUNCT
afs-72863	332	14	cavaignac	cavaignac	PROPN
afs-72863	332	15	,	,	PUNCT
afs-72863	332	16	s.	s.	PROPN
afs-72863	332	17	&	&	CCONJ
afs-72863	332	18	trust	trust	PROPN
afs-72863	332	19	,	,	PUNCT
afs-72863	332	20	t.j	t.j	PROPN
afs-72863	332	21	.	.	PROPN
afs-72863	332	22	1993	1993	NUM
afs-72863	332	23	.	.	PUNCT
afs-72863	333	1	transcriptional	transcriptional	ADJ
afs-72863	333	2	analysis	analysis	NOUN
afs-72863	333	3	of	of	ADP
afs-72863	333	4	the	the	DET
afs-72863	333	5	aeromonas	aeromonas	PROPN
afs-72863	333	6	salmonicida	salmonicida	PROPN
afs-72863	333	7	s	s	PART
afs-72863	333	8	-	-	PUNCT
afs-72863	333	9	layer	layer	NOUN
afs-72863	333	10	protein	protein	NOUN
afs-72863	333	11	gene	gene	NOUN
afs-72863	333	12	vapa	vapa	VERB
afs-72863	333	13	.	.	PUNCT
afs-72863	334	1	journal	journal	NOUN
afs-72863	334	2	of	of	ADP
afs-72863	334	3	bacteriology	bacteriology	NOUN
afs-72863	334	4	175	175	NUM
afs-72863	334	5	:	:	PUNCT
afs-72863	334	6	7968	7968	NUM
afs-72863	334	7	-	-	SYM
afs-72863	334	8	7975	7975	NUM
afs-72863	334	9	.	.	PUNCT
afs-72863	335	1	de	de	PROPN
afs-72863	335	2	vos	vos	PROPN
afs-72863	335	3	,	,	PUNCT
afs-72863	335	4	w.m	w.m	PROPN
afs-72863	335	5	.	.	PROPN
afs-72863	335	6	,	,	PUNCT
afs-72863	335	7	huis	huis	PROPN
afs-72863	335	8	in’t	in’t	PROPN
afs-72863	335	9	veld	veld	PROPN
afs-72863	335	10	,	,	PUNCT
afs-72863	335	11	j.h.j	j.h.j	PROPN
afs-72863	335	12	.	.	PROPN
afs-72863	335	13	&	&	CCONJ
afs-72863	335	14	poolman	poolman	PROPN
afs-72863	335	15	,	,	PUNCT
afs-72863	335	16	b.	b.	PROPN
afs-72863	335	17	(	(	PUNCT
afs-72863	335	18	eds	eds	PROPN
afs-72863	335	19	)	)	PUNCT
afs-72863	335	20	.	.	PUNCT
afs-72863	336	1	1993	1993	NUM
afs-72863	336	2	.	.	PUNCT
afs-72863	337	1	lactic	lactic	ADJ
afs-72863	337	2	acid	acid	NOUN
afs-72863	337	3	bacteria	bacteria	NOUN
afs-72863	337	4	:	:	PUNCT
afs-72863	337	5	genetics	genetic	NOUN
afs-72863	337	6	,	,	PUNCT
afs-72863	337	7	metabolism	metabolism	NOUN
afs-72863	337	8	and	and	CCONJ
afs-72863	337	9	applications	application	NOUN
afs-72863	337	10	.	.	PUNCT
afs-72863	338	1	fems	fems	PROPN
afs-72863	338	2	microbiology	microbiology	NOUN
afs-72863	338	3	reviews	review	NOUN
afs-72863	338	4	12:1	12:1	NUM
afs-72863	338	5	-	-	SYM
afs-72863	338	6	272	272	NUM
afs-72863	338	7	.	.	PUNCT
afs-72863	338	8	de	de	PROPN
afs-72863	338	9	vuyst	vuyst	PROPN
afs-72863	338	10	,	,	PUNCT
afs-72863	338	11	l.	l.	PROPN
afs-72863	338	12	&	&	CCONJ
afs-72863	338	13	vandamme	vandamme	PROPN
afs-72863	338	14	,	,	PUNCT
afs-72863	338	15	e.j	e.j	PROPN
afs-72863	338	16	.	.	PROPN
afs-72863	338	17	1994	1994	NUM
afs-72863	338	18	.	.	PUNCT
afs-72863	339	1	lactic	lactic	ADJ
afs-72863	339	2	acid	acid	NOUN
afs-72863	339	3	bacteria	bacteria	NOUN
afs-72863	339	4	and	and	CCONJ
afs-72863	339	5	bacteriocins	bacteriocin	NOUN
afs-72863	339	6	:	:	PUNCT
afs-72863	339	7	their	their	PRON
afs-72863	339	8	practical	practical	ADJ
afs-72863	339	9	importance	importance	NOUN
afs-72863	339	10	.	.	PUNCT
afs-72863	340	1	in	in	ADP
afs-72863	340	2	:	:	PUNCT
afs-72863	340	3	de	de	X
afs-72863	340	4	vuyst	vuyst	NOUN
afs-72863	340	5	,	,	PUNCT
afs-72863	340	6	l.	l.	PROPN
afs-72863	340	7	&	&	CCONJ
afs-72863	340	8	vandamme	vandamme	PROPN
afs-72863	340	9	,	,	PUNCT
afs-72863	340	10	e.j	e.j	PROPN
afs-72863	340	11	.	.	PROPN
afs-72863	340	12	(	(	PUNCT
afs-72863	340	13	eds	ed	NOUN
afs-72863	340	14	.	.	PUNCT
afs-72863	340	15	)	)	PUNCT
afs-72863	340	16	.	.	PUNCT
afs-72863	341	1	bacteriocins	bacteriocin	NOUN
afs-72863	341	2	of	of	ADP
afs-72863	341	3	lactic	lactic	ADJ
afs-72863	341	4	acid	acid	NOUN
afs-72863	341	5	bacteria	bacteria	NOUN
afs-72863	341	6	.	.	PUNCT
afs-72863	342	1	london	london	PROPN
afs-72863	342	2	:	:	PUNCT
afs-72863	342	3	blackie	blackie	NOUN
afs-72863	342	4	academic	academic	PROPN
afs-72863	342	5	&	&	CCONJ
afs-72863	342	6	professional	professional	PROPN
afs-72863	342	7	,	,	PUNCT
afs-72863	342	8	p.	p.	NOUN
afs-72863	342	9	1	1	NUM
afs-72863	342	10	-	-	SYM
afs-72863	342	11	11	11	NUM
afs-72863	342	12	.	.	PUNCT
afs-72863	343	1	dudley	dudley	PROPN
afs-72863	343	2	,	,	PUNCT
afs-72863	343	3	e.	e.	PROPN
afs-72863	343	4	,	,	PUNCT
afs-72863	343	5	husgen	husgen	PROPN
afs-72863	343	6	,	,	PUNCT
afs-72863	343	7	a.	a.	PROPN
afs-72863	343	8	,	,	PUNCT
afs-72863	343	9	hr	hr	PROPN
afs-72863	343	10	,	,	PUNCT
afs-72863	343	11	w.	w.	PROPN
afs-72863	343	12	&	&	CCONJ
afs-72863	343	13	steele	steele	PROPN
afs-72863	343	14	,	,	PUNCT
afs-72863	343	15	j.	j.	PROPN
afs-72863	343	16	1996	1996	NUM
afs-72863	343	17	.	.	PUNCT
afs-72863	344	1	sequencing	sequence	VERB
afs-72863	344	2	,	,	PUNCT
afs-72863	344	3	distribution	distribution	NOUN
afs-72863	344	4	and	and	CCONJ
afs-72863	344	5	inactivation	inactivation	NOUN
afs-72863	344	6	of	of	ADP
afs-72863	344	7	the	the	DET
afs-72863	344	8	dipeptidase	dipeptidase	NOUN
afs-72863	344	9	a	a	DET
afs-72863	344	10	gene	gene	NOUN
afs-72863	344	11	(	(	PUNCT
afs-72863	344	12	pepda	pepda	NOUN
afs-72863	344	13	)	)	PUNCT
afs-72863	344	14	from	from	ADP
afs-72863	344	15	lactobacillus	lactobacillus	ADJ
afs-72863	344	16	helveticus	helveticus	NOUN
afs-72863	344	17	cnrz32	cnrz32	NOUN
afs-72863	344	18	.	.	PUNCT
afs-72863	345	1	journal	journal	PROPN
afs-72863	345	2	of	of	ADP
afs-72863	345	3	bacteriology	bacteriology	NOUN
afs-72863	345	4	178	178	NUM
afs-72863	345	5	:	:	PUNCT
afs-72863	345	6	710	710	NUM
afs-72863	345	7	-	-	SYM
afs-72863	345	8	714	714	NUM
afs-72863	345	9	.	.	PUNCT
afs-72863	345	10	&	&	CCONJ
afs-72863	345	11	steele	steele	PROPN
afs-72863	345	12	,	,	PUNCT
afs-72863	345	13	j.	j.	PROPN
afs-72863	345	14	1994	1994	NUM
afs-72863	345	15	.	.	PUNCT
afs-72863	346	1	nucleotide	nucleotide	ADJ
afs-72863	346	2	sequence	sequence	NOUN
afs-72863	346	3	and	and	CCONJ
afs-72863	346	4	distribution	distribution	NOUN
afs-72863	346	5	of	of	ADP
afs-72863	346	6	the	the	DET
afs-72863	346	7	peppn	peppn	NOUN
afs-72863	346	8	gene	gene	NOUN
afs-72863	346	9	from	from	ADP
afs-72863	346	10	lactobacillus	lactobacillus	NOUN
afs-72863	346	11	helveticus	helveticus	NOUN
afs-72863	346	12	cnrz32	cnrz32	NOUN
afs-72863	346	13	.	.	PUNCT
afs-72863	347	1	fems	fems	PROPN
afs-72863	347	2	microbiology	microbiology	NOUN
afs-72863	347	3	letters	letter	NOUN
afs-72863	347	4	119	119	NUM
afs-72863	347	5	:	:	SYM
afs-72863	347	6	4146	4146	NUM
afs-72863	347	7	.	.	PUNCT
afs-72863	348	1	el	el	PROPN
afs-72863	348	2	soda	soda	PROPN
afs-72863	348	3	,	,	PUNCT
afs-72863	348	4	m.	m.	NOUN
afs-72863	348	5	1993	1993	NUM
afs-72863	348	6	.	.	PUNCT
afs-72863	349	1	the	the	DET
afs-72863	349	2	role	role	NOUN
afs-72863	349	3	of	of	ADP
afs-72863	349	4	lactic	lactic	ADJ
afs-72863	349	5	acid	acid	NOUN
afs-72863	349	6	bacteria	bacteria	NOUN
afs-72863	349	7	in	in	ADP
afs-72863	349	8	accelerated	accelerate	VERB
afs-72863	349	9	cheese	cheese	NOUN
afs-72863	349	10	ripening	ripening	NOUN
afs-72863	349	11	.	.	PUNCT
afs-72863	350	1	fems	fems	PROPN
afs-72863	350	2	microbiology	microbiology	NOUN
afs-72863	350	3	reviews	review	NOUN
afs-72863	350	4	12	12	NUM
afs-72863	350	5	:	:	SYM
afs-72863	350	6	239	239	NUM
afs-72863	350	7	-	-	SYM
afs-72863	350	8	252	252	NUM
afs-72863	350	9	.	.	PUNCT
afs-72863	351	1	fernändez	fernändez	PROPN
afs-72863	351	2	,	,	PUNCT
afs-72863	351	3	l.	l.	PROPN
afs-72863	351	4	,	,	PUNCT
afs-72863	351	5	bhowmik	bhowmik	ADJ
afs-72863	351	6	,	,	PUNCT
afs-72863	351	7	t.	t.	PROPN
afs-72863	351	8	&	&	CCONJ
afs-72863	351	9	steele	steele	PROPN
afs-72863	351	10	,	,	PUNCT
afs-72863	351	11	j.	j.	PROPN
afs-72863	351	12	1994	1994	NUM
afs-72863	351	13	.	.	PUNCT
afs-72863	352	1	characterization	characterization	NOUN
afs-72863	352	2	of	of	ADP
afs-72863	352	3	the	the	DET
afs-72863	352	4	lactobacillus	lactobacillus	NOUN
afs-72863	352	5	helveticus	helveticus	NOUN
afs-72863	352	6	cnrz32	cnrz32	NOUN
afs-72863	352	7	pepc	pepc	NOUN
afs-72863	352	8	gene	gene	PROPN
afs-72863	352	9	.	.	PUNCT
afs-72863	353	1	applied	apply	VERB
afs-72863	353	2	and	and	CCONJ
afs-72863	353	3	environmentalmicrobiology	environmentalmicrobiology	NOUN
afs-72863	353	4	60	60	NUM
afs-72863	353	5	:	:	PUNCT
afs-72863	353	6	333	333	NUM
afs-72863	353	7	-	-	SYM
afs-72863	353	8	336	336	NUM
afs-72863	353	9	.	.	PUNCT
afs-72863	354	1	279	279	NUM
afs-72863	354	2	vol	vol	NOUN
afs-72863	354	3	.	.	PUNCT
afs-72863	355	1	7(1998	7(1998	NUM
afs-72863	355	2	):	):	PUNCT
afs-72863	355	3	267	267	NUM
afs-72863	355	4	-	-	SYM
afs-72863	355	5	282	282	NUM
afs-72863	355	6	.	.	PUNCT
afs-72863	356	1	agricultural	agricultural	ADJ
afs-72863	356	2	and	and	CCONJ
afs-72863	356	3	food	food	NOUN
afs-72863	356	4	science	science	NOUN
afs-72863	356	5	in	in	ADP
afs-72863	356	6	finland	finland	PROPN
afs-72863	356	7	fox	fox	PROPN
afs-72863	356	8	,	,	PUNCT
afs-72863	356	9	p.	p.	NOUN
afs-72863	356	10	1989	1989	NUM
afs-72863	356	11	.	.	PUNCT
afs-72863	357	1	proteolysis	proteolysis	NOUN
afs-72863	357	2	during	during	ADP
afs-72863	357	3	cheese	cheese	NOUN
afs-72863	357	4	manufacture	manufacture	NOUN
afs-72863	357	5	and	and	CCONJ
afs-72863	357	6	ripening	ripen	VERB
afs-72863	357	7	.	.	PUNCT
afs-72863	358	1	journal	journal	NOUN
afs-72863	358	2	of	of	ADP
afs-72863	358	3	dairy	dairy	NOUN
afs-72863	358	4	science	science	NOUN
afs-72863	358	5	.	.	PUNCT
afs-72863	359	1	72	72	NUM
afs-72863	359	2	:	:	SYM
afs-72863	359	3	1379	1379	NUM
afs-72863	359	4	-	-	SYM
afs-72863	359	5	1400	1400	NUM
afs-72863	359	6	.	.	PUNCT
afs-72863	360	1	gasson	gasson	NOUN
afs-72863	360	2	,	,	PUNCT
afs-72863	360	3	m.j	m.j	PROPN
afs-72863	360	4	.	.	PROPN
afs-72863	360	5	&	&	CCONJ
afs-72863	360	6	de	de	PROPN
afs-72863	360	7	vos	vos	PROPN
afs-72863	360	8	,	,	PUNCT
afs-72863	360	9	w.m	w.m	PROPN
afs-72863	360	10	.	.	PUNCT
afs-72863	360	11	(	(	PUNCT
afs-72863	360	12	eds	ed	NOUN
afs-72863	360	13	.	.	PUNCT
afs-72863	360	14	)	)	PUNCT
afs-72863	360	15	.	.	PUNCT
afs-72863	361	1	1994	1994	NUM
afs-72863	361	2	.	.	PUNCT
afs-72863	362	1	genetics	genetic	NOUN
afs-72863	362	2	and	and	CCONJ
afs-72863	362	3	biotechnologyof	biotechnologyof	NOUN
afs-72863	362	4	lactic	lactic	ADJ
afs-72863	362	5	acid	acid	NOUN
afs-72863	362	6	bacteria	bacteria	NOUN
afs-72863	362	7	.	.	PUNCT
afs-72863	363	1	1	1	X
afs-72863	363	2	.	.	X
afs-72863	364	1	ed	ed	NOUN
afs-72863	364	2	.	.	PUNCT
afs-72863	365	1	london	london	PROPN
afs-72863	365	2	:	:	PUNCT
afs-72863	365	3	blackie	blackie	NOUN
afs-72863	365	4	academic	academic	PROPN
afs-72863	365	5	&	&	CCONJ
afs-72863	365	6	professional	professional	ADJ
afs-72863	365	7	.	.	PUNCT
afs-72863	366	1	300	300	NUM
afs-72863	366	2	p.	p.	NOUN
afs-72863	366	3	holzapfel	holzapfel	NOUN
afs-72863	366	4	,	,	PUNCT
afs-72863	366	5	w.h	w.h	PROPN
afs-72863	366	6	.	.	PROPN
afs-72863	366	7	,	,	PUNCT
afs-72863	366	8	geisen	geisen	PROPN
afs-72863	366	9	,	,	PUNCT
afs-72863	366	10	r.	r.	PROPN
afs-72863	366	11	&	&	CCONJ
afs-72863	366	12	schillinger	schillinger	PROPN
afs-72863	366	13	,	,	PUNCT
afs-72863	366	14	u.	u.	NOUN
afs-72863	366	15	1995	1995	NUM
afs-72863	366	16	.	.	PUNCT
afs-72863	367	1	biological	biological	ADJ
afs-72863	367	2	preservation	preservation	NOUN
afs-72863	367	3	of	of	ADP
afs-72863	367	4	foods	food	NOUN
afs-72863	367	5	with	with	ADP
afs-72863	367	6	reference	reference	NOUN
afs-72863	367	7	to	to	ADP
afs-72863	367	8	protective	protective	ADJ
afs-72863	367	9	cultures	culture	NOUN
afs-72863	367	10	,	,	PUNCT
afs-72863	367	11	bacteriocins	bacteriocin	NOUN
afs-72863	367	12	and	and	CCONJ
afs-72863	367	13	food	food	NOUN
afs-72863	367	14	-	-	PUNCT
afs-72863	367	15	grade	grade	NOUN
afs-72863	367	16	enzymes	enzyme	NOUN
afs-72863	367	17	.	.	PUNCT
afs-72863	368	1	international	international	ADJ
afs-72863	368	2	journalof	journalof	ADJ
afs-72863	368	3	food	food	NOUN
afs-72863	368	4	microbiology	microbiology	NOUN
afs-72863	368	5	24	24	NUM
afs-72863	368	6	:	:	PUNCT
afs-72863	368	7	343	343	NUM
afs-72863	368	8	-	-	SYM
afs-72863	368	9	362	362	NUM
afs-72863	368	10	.	.	PUNCT
afs-72863	369	1	jensen	jensen	PROPN
afs-72863	369	2	,	,	PUNCT
afs-72863	369	3	r.g	r.g	PROPN
afs-72863	369	4	.	.	PROPN
afs-72863	369	5	(	(	PUNCT
afs-72863	369	6	ed	ed	NOUN
afs-72863	369	7	,	,	PUNCT
afs-72863	369	8	)	)	PUNCT
afs-72863	369	9	.	.	PUNCT
afs-72863	370	1	1995	1995	NUM
afs-72863	370	2	.	.	PUNCT
afs-72863	371	1	handbook	handbook	NOUN
afs-72863	371	2	ofmilk	ofmilk	NOUN
afs-72863	371	3	composition	composition	NOUN
afs-72863	371	4	.	.	PUNCT
afs-72863	372	1	san	san	PROPN
afs-72863	372	2	diego	diego	PROPN
afs-72863	372	3	;	;	PUNCT
afs-72863	372	4	academic	academic	ADJ
afs-72863	372	5	press	press	NOUN
afs-72863	372	6	.	.	PUNCT
afs-72863	373	1	919	919	NUM
afs-72863	373	2	p.	p.	NOUN
afs-72863	373	3	kahala	kahala	PROPN
afs-72863	373	4	,	,	PUNCT
afs-72863	373	5	m.	m.	NOUN
afs-72863	373	6	&	&	CCONJ
afs-72863	373	7	palva	palva	PROPN
afs-72863	373	8	,	,	PUNCT
afs-72863	373	9	a.	a.	NOUN
afs-72863	373	10	1998	1998	NUM
afs-72863	373	11	.	.	PUNCT
afs-72863	374	1	the	the	DET
afs-72863	374	2	expression	expression	NOUN
afs-72863	374	3	signals	signal	NOUN
afs-72863	374	4	of	of	ADP
afs-72863	374	5	the	the	DET
afs-72863	374	6	lactobacillus	lactobacillus	NOUN
afs-72863	374	7	brevis	brevis	NOUN
afs-72863	374	8	sipa	sipa	PROPN
afs-72863	374	9	gene	gene	PROPN
afs-72863	374	10	directs	direct	VERB
afs-72863	374	11	efficient	efficient	ADJ
afs-72863	374	12	heterologous	heterologous	ADJ
afs-72863	374	13	protein	protein	NOUN
afs-72863	374	14	production	production	NOUN
afs-72863	374	15	in	in	ADP
afs-72863	374	16	lactic	lactic	ADJ
afs-72863	374	17	acid	acid	NOUN
afs-72863	374	18	bacteria	bacteria	NOUN
afs-72863	374	19	.	.	PUNCT
afs-72863	375	1	applied	apply	VERB
afs-72863	375	2	microbiology	microbiology	NOUN
afs-72863	375	3	and	and	CCONJ
afs-72863	375	4	biotechnology	biotechnology	NOUN
afs-72863	375	5	(	(	PUNCT
afs-72863	375	6	in	in	ADP
afs-72863	375	7	press	press	NOUN
afs-72863	375	8	)	)	PUNCT
afs-72863	375	9	.	.	PUNCT
afs-72863	376	1	,	,	PUNCT
afs-72863	376	2	savijoki	savijoki	PROPN
afs-72863	376	3	,	,	PUNCT
afs-72863	376	4	k.	k.	PROPN
afs-72863	376	5	&	&	CCONJ
afs-72863	376	6	palva	palva	PROPN
afs-72863	376	7	,	,	PUNCT
afs-72863	376	8	a.	a.	NOUN
afs-72863	376	9	1997	1997	NUM
afs-72863	376	10	,	,	PUNCT
afs-72863	376	11	in	in	ADP
afs-72863	376	12	vivo	vivo	ADJ
afs-72863	376	13	expression	expression	NOUN
afs-72863	376	14	of	of	ADP
afs-72863	376	15	the	the	DET
afs-72863	376	16	lactobacillus	lactobacillus	NOUN
afs-72863	376	17	brevis	brevis	NOUN
afs-72863	376	18	s	s	NOUN
afs-72863	376	19	-	-	PUNCT
afs-72863	376	20	layer	layer	NOUN
afs-72863	376	21	gene	gene	NOUN
afs-72863	376	22	.	.	PUNCT
afs-72863	377	1	journal	journal	NOUN
afs-72863	377	2	of	of	ADP
afs-72863	377	3	bacteriology	bacteriology	NOUN
afs-72863	377	4	179	179	NUM
afs-72863	377	5	:	:	PUNCT
afs-72863	377	6	284	284	NUM
afs-72863	377	7	-	-	SYM
afs-72863	377	8	286	286	NUM
afs-72863	377	9	.	.	PUNCT
afs-72863	378	1	kailasapathy	kailasapathy	PROPN
afs-72863	378	2	,	,	PUNCT
afs-72863	378	3	k.	k.	PROPN
afs-72863	378	4	&	&	CCONJ
afs-72863	378	5	rybka	rybka	PROPN
afs-72863	378	6	,	,	PUNCT
afs-72863	378	7	s.	s.	PROPN
afs-72863	378	8	1997	1997	NUM
afs-72863	378	9	.	.	PUNCT
afs-72863	379	1	l.	l.	PROPN
afs-72863	379	2	acidophilus	acidophilus	PROPN
afs-72863	379	3	and	and	CCONJ
afs-72863	379	4	bifidobacterium	bifidobacterium	NOUN
afs-72863	379	5	spp	spp	NOUN
afs-72863	379	6	.	.	PUNCT
afs-72863	380	1	their	their	PRON
afs-72863	380	2	therapeuticpotential	therapeuticpotential	ADJ
afs-72863	380	3	and	and	CCONJ
afs-72863	380	4	survival	survival	NOUN
afs-72863	380	5	in	in	ADP
afs-72863	380	6	yogurt	yogurt	PROPN
afs-72863	380	7	.	.	PUNCT
afs-72863	381	1	australian	australian	ADJ
afs-72863	381	2	journal	journal	NOUN
afs-72863	381	3	of	of	ADP
afs-72863	381	4	dairy	dairy	NOUN
afs-72863	381	5	technology	technology	NOUN
afs-72863	381	6	52	52	NUM
afs-72863	381	7	:	:	SYM
afs-72863	381	8	28	28	NUM
afs-72863	381	9	-	-	SYM
afs-72863	381	10	35	35	NUM
afs-72863	381	11	.	.	PUNCT
afs-72863	382	1	klaenhammer	klaenhammer	NOUN
afs-72863	382	2	,	,	PUNCT
afs-72863	382	3	t.r	t.r	PROPN
afs-72863	382	4	.	.	PROPN
afs-72863	382	5	1995	1995	NUM
afs-72863	382	6	.	.	PUNCT
afs-72863	383	1	genetics	genetic	NOUN
afs-72863	383	2	of	of	ADP
afs-72863	383	3	intestinal	intestinal	ADJ
afs-72863	383	4	lactobacilli	lactobacilli	PROPN
afs-72863	383	5	.	.	PUNCT
afs-72863	384	1	international	international	ADJ
afs-72863	384	2	dairy	dairy	NOUN
afs-72863	384	3	journal	journal	NOUN
afs-72863	384	4	5	5	NUM
afs-72863	384	5	;	;	PUNCT
afs-72863	384	6	1019	1019	NUM
afs-72863	384	7	-	-	SYM
afs-72863	384	8	1058	1058	NUM
afs-72863	384	9	.	.	PUNCT
afs-72863	385	1	klein	klein	PROPN
afs-72863	385	2	,	,	PUNCT
afs-72863	385	3	j.	j.	PROPN
afs-72863	385	4	,	,	PUNCT
afs-72863	385	5	klein	klein	PROPN
afs-72863	385	6	,	,	PUNCT
afs-72863	385	7	u.	u.	PROPN
afs-72863	385	8	,	,	PUNCT
afs-72863	385	9	schad	schad	VERB
afs-72863	385	10	,	,	PUNCT
afs-72863	385	11	m.	m.	NOUN
afs-72863	385	12	&	&	CCONJ
afs-72863	385	13	plapp	plapp	PROPN
afs-72863	385	14	,	,	PUNCT
afs-72863	385	15	r.	r.	PROPN
afs-72863	385	16	1993	1993	NUM
afs-72863	385	17	.	.	PUNCT
afs-72863	386	1	cloning	cloning	NOUN
afs-72863	386	2	,	,	PUNCT
afs-72863	386	3	dna	dna	NOUN
afs-72863	386	4	sequence	sequence	NOUN
afs-72863	386	5	and	and	CCONJ
afs-72863	386	6	partial	partial	ADJ
afs-72863	386	7	characterization	characterization	NOUN
afs-72863	386	8	of	of	ADP
afs-72863	386	9	pepn	pepn	NOUN
afs-72863	386	10	,	,	PUNCT
afs-72863	386	11	a	a	DET
afs-72863	386	12	lysyl	lysyl	NOUN
afs-72863	386	13	aminopeptidase	aminopeptidase	NOUN
afs-72863	386	14	from	from	ADP
afs-72863	386	15	lactobacillus	lactobacillus	NOUN
afs-72863	386	16	delbrueckii	delbrueckii	ADJ
afs-72863	386	17	ssp	ssp	PROPN
afs-72863	386	18	.	.	PUNCT
afs-72863	387	1	lactis	lactis	PROPN
afs-72863	387	2	dsm729o	dsm729o	PROPN
afs-72863	387	3	.	.	PUNCT
afs-72863	388	1	european	european	PROPN
afs-72863	388	2	journal	journal	PROPN
afs-72863	388	3	ofbiochemistry	ofbiochemistry	NOUN
afs-72863	388	4	217	217	NUM
afs-72863	388	5	:	:	PUNCT
afs-72863	388	6	105	105	NUM
afs-72863	388	7	-	-	SYM
afs-72863	388	8	114	114	NUM
afs-72863	388	9	.	.	PUNCT
afs-72863	388	10	,	,	PUNCT
afs-72863	388	11	schmidt	schmidt	PROPN
afs-72863	388	12	,	,	PUNCT
afs-72863	388	13	u.	u.	PROPN
afs-72863	388	14	&	&	CCONJ
afs-72863	388	15	plapp	plapp	PROPN
afs-72863	388	16	,	,	PUNCT
afs-72863	388	17	r.	r.	PROPN
afs-72863	388	18	1994	1994	NUM
afs-72863	388	19	.	.	PUNCT
afs-72863	389	1	cloning	cloning	NOUN
afs-72863	389	2	,	,	PUNCT
afs-72863	389	3	heterologous	heterologous	ADJ
afs-72863	389	4	expression	expression	NOUN
afs-72863	389	5	,	,	PUNCT
afs-72863	389	6	and	and	CCONJ
afs-72863	389	7	sequencing	sequencing	NOUN
afs-72863	389	8	of	of	ADP
afs-72863	389	9	a	a	DET
afs-72863	389	10	novel	novel	ADJ
afs-72863	389	11	proline	proline	NOUN
afs-72863	389	12	iminopeptidase	iminopeptidase	NOUN
afs-72863	389	13	gene	gene	NOUN
afs-72863	389	14	,	,	PUNCT
afs-72863	389	15	pepi	pepi	PROPN
afs-72863	389	16	,	,	PUNCT
afs-72863	389	17	from	from	ADP
afs-72863	389	18	lactobacillus	lactobacillus	NOUN
afs-72863	389	19	delbrueckii	delbrueckii	PROPN
afs-72863	389	20	susbsp	susbsp	PROPN
afs-72863	389	21	.	.	PUNCT
afs-72863	390	1	lactis	lactis	PROPN
afs-72863	390	2	dsm729o	dsm729o	PROPN
afs-72863	390	3	.	.	PUNCT
afs-72863	391	1	microbiology	microbiology	NOUN
afs-72863	391	2	140	140	NUM
afs-72863	391	3	:	:	PUNCT
afs-72863	391	4	1133	1133	NUM
afs-72863	391	5	-	-	SYM
afs-72863	391	6	1139	1139	NUM
afs-72863	391	7	.	.	PUNCT
afs-72863	392	1	koivula	koivula	NOUN
afs-72863	392	2	,	,	PUNCT
afs-72863	392	3	t.	t.	PROPN
afs-72863	392	4	,	,	PUNCT
afs-72863	392	5	sibakov	sibakov	NOUN
afs-72863	392	6	,	,	PUNCT
afs-72863	392	7	m.	m.	NOUN
afs-72863	392	8	&	&	CCONJ
afs-72863	392	9	palva	palva	PROPN
afs-72863	392	10	,	,	PUNCT
afs-72863	392	11	i.	i.	PROPN
afs-72863	392	12	1991	1991	NUM
afs-72863	392	13	.	.	PUNCT
afs-72863	393	1	isolation	isolation	NOUN
afs-72863	393	2	and	and	CCONJ
afs-72863	393	3	characterization	characterization	NOUN
afs-72863	393	4	of	of	ADP
afs-72863	393	5	lactococcus	lactococcus	PROPN
afs-72863	393	6	lactis	lactis	PROPN
afs-72863	393	7	subsp	subsp	PROPN
afs-72863	393	8	.	.	PUNCT
afs-72863	394	1	lactis	lactis	PROPN
afs-72863	394	2	promoters	promoter	NOUN
afs-72863	394	3	.	.	PUNCT
afs-72863	395	1	applied	apply	VERB
afs-72863	395	2	and	and	CCONJ
afs-72863	395	3	environmental	environmental	ADJ
afs-72863	395	4	microbiology	microbiology	NOUN
afs-72863	395	5	57	57	NUM
afs-72863	395	6	:	:	PUNCT
afs-72863	395	7	333	333	NUM
afs-72863	395	8	-	-	SYM
afs-72863	395	9	340	340	NUM
afs-72863	395	10	.	.	PUNCT
afs-72863	396	1	kok	kok	PROPN
afs-72863	396	2	,	,	PUNCT
afs-72863	396	3	j.	j.	PROPN
afs-72863	396	4	,	,	PUNCT
afs-72863	396	5	van	van	PROPN
afs-72863	396	6	der	der	NOUN
afs-72863	396	7	vossen	vossen	NOUN
afs-72863	396	8	,	,	PUNCT
afs-72863	396	9	m.	m.	PROPN
afs-72863	396	10	b.	b.	PROPN
afs-72863	396	11	m.	m.	PROPN
afs-72863	396	12	&	&	CCONJ
afs-72863	396	13	venerna	venerna	PROPN
afs-72863	396	14	,	,	PUNCT
afs-72863	396	15	g.	g.	PROPN
afs-72863	396	16	1984	1984	NUM
afs-72863	396	17	.	.	PUNCT
afs-72863	397	1	construction	construction	NOUN
afs-72863	397	2	of	of	ADP
afs-72863	397	3	plasmid	plasmid	ADJ
afs-72863	397	4	cloning	cloning	NOUN
afs-72863	397	5	vectors	vector	NOUN
afs-72863	397	6	for	for	ADP
afs-72863	397	7	lactic	lactic	ADJ
afs-72863	397	8	streptococci	streptococci	NOUN
afs-72863	397	9	which	which	PRON
afs-72863	397	10	also	also	ADV
afs-72863	397	11	replicate	replicate	VERB
afs-72863	397	12	in	in	ADP
afs-72863	397	13	bacillus	bacillus	NOUN
afs-72863	397	14	subtilis	subtili	NOUN
afs-72863	397	15	and	and	CCONJ
afs-72863	397	16	escherichia	escherichia	NOUN
afs-72863	397	17	coli	coli	NOUN
afs-72863	397	18	.	.	PUNCT
afs-72863	398	1	applied	apply	VERB
afs-72863	398	2	and	and	CCONJ
afs-72863	398	3	environmental	environmental	ADJ
afs-72863	398	4	microbiology	microbiology	NOUN
afs-72863	398	5	48	48	NUM
afs-72863	398	6	:	:	PUNCT
afs-72863	398	7	726	726	NUM
afs-72863	398	8	-	-	SYM
afs-72863	398	9	731	731	NUM
afs-72863	398	10	.	.	PUNCT
afs-72863	399	1	kunji	kunji	X
afs-72863	399	2	,	,	PUNCT
afs-72863	399	3	e.r.s	e.r.s	INTJ
afs-72863	399	4	.	.	PUNCT
afs-72863	399	5	,	,	PUNCT
afs-72863	399	6	mierau	mierau	NOUN
afs-72863	399	7	,	,	PUNCT
afs-72863	399	8	1	1	NUM
afs-72863	399	9	.	.	NUM
afs-72863	399	10	,	,	PUNCT
afs-72863	399	11	hagting	hagting	PROPN
afs-72863	399	12	,	,	PUNCT
afs-72863	399	13	a.	a.	NOUN
afs-72863	399	14	,	,	PUNCT
afs-72863	399	15	poolman	poolman	PROPN
afs-72863	399	16	,	,	PUNCT
afs-72863	399	17	b.	b.	PROPN
afs-72863	399	18	&	&	CCONJ
afs-72863	399	19	konings	konings	PROPN
afs-72863	399	20	,	,	PUNCT
afs-72863	399	21	w.n	w.n	PROPN
afs-72863	399	22	.	.	PROPN
afs-72863	400	1	1996.the	1996.the	DET
afs-72863	400	2	proteolytic	proteolytic	ADJ
afs-72863	400	3	systems	system	NOUN
afs-72863	400	4	of	of	ADP
afs-72863	400	5	lactic	lactic	ADJ
afs-72863	400	6	acid	acid	NOUN
afs-72863	400	7	bacteria	bacteria	NOUN
afs-72863	400	8	.	.	PUNCT
afs-72863	401	1	antonie	antonie	PROPN
afs-72863	401	2	van	van	PROPN
afs-72863	401	3	leeuwenhoek	leeuwenhoek	PROPN
afs-72863	401	4	70	70	NUM
afs-72863	401	5	:	:	PUNCT
afs-72863	401	6	187	187	NUM
afs-72863	401	7	-	-	SYM
afs-72863	401	8	221	221	NUM
afs-72863	401	9	.	.	PUNCT
afs-72863	402	1	lindegren	lindegren	PROPN
afs-72863	402	2	,	,	PUNCT
afs-72863	402	3	s.e	s.e	PROPN
afs-72863	402	4	.	.	PROPN
afs-72863	402	5	&	&	CCONJ
afs-72863	402	6	dobrogosz	dobrogosz	PROPN
afs-72863	402	7	,	,	PUNCT
afs-72863	402	8	w.j	w.j	PROPN
afs-72863	402	9	.	.	PROPN
afs-72863	402	10	1990	1990	NUM
afs-72863	402	11	.	.	PUNCT
afs-72863	403	1	antagonistic	antagonistic	ADJ
afs-72863	403	2	activities	activity	NOUN
afs-72863	403	3	of	of	ADP
afs-72863	403	4	lactic	lactic	ADJ
afs-72863	403	5	acid	acid	NOUN
afs-72863	403	6	bacteria	bacteria	NOUN
afs-72863	403	7	in	in	ADP
afs-72863	403	8	food	food	NOUN
afs-72863	403	9	and	and	CCONJ
afs-72863	403	10	feed	feed	NOUN
afs-72863	403	11	fermentations	fermentation	NOUN
afs-72863	403	12	.	.	PUNCT
afs-72863	404	1	fems	fems	PROPN
afs-72863	404	2	microbiology	microbiology	NOUN
afs-72863	404	3	reviews	review	NOUN
afs-72863	404	4	87	87	NUM
afs-72863	404	5	:	:	SYM
afs-72863	404	6	149163	149163	NUM
afs-72863	404	7	.	.	PUNCT
afs-72863	405	1	mayo	mayo	NOUN
afs-72863	405	2	,	,	PUNCT
afs-72863	405	3	8	8	NUM
afs-72863	405	4	.	.	NUM
afs-72863	405	5	,	,	PUNCT
afs-72863	405	6	kok	kok	PROPN
afs-72863	405	7	,	,	PUNCT
afs-72863	405	8	j.	j.	PROPN
afs-72863	405	9	,	,	PUNCT
afs-72863	405	10	venerna	venerna	PROPN
afs-72863	405	11	,	,	PUNCT
afs-72863	405	12	k.	k.	PROPN
afs-72863	405	13	,	,	PUNCT
afs-72863	405	14	boeckelmann	boeckelmann	PROPN
afs-72863	405	15	,	,	PUNCT
afs-72863	405	16	w.	w.	PROPN
afs-72863	405	17	,	,	PUNCT
afs-72863	405	18	teuber	teuber	PROPN
afs-72863	405	19	,	,	PUNCT
afs-72863	405	20	m.	m.	NOUN
afs-72863	405	21	,	,	PUNCT
afs-72863	405	22	reinke	reinke	PROPN
afs-72863	405	23	,	,	PUNCT
afs-72863	405	24	h.	h.	PROPN
afs-72863	405	25	&	&	CCONJ
afs-72863	405	26	venerna	venerna	PROPN
afs-72863	405	27	,	,	PUNCT
afs-72863	405	28	g.	g.	PROPN
afs-72863	405	29	1991	1991	NUM
afs-72863	405	30	.	.	PUNCT
afs-72863	406	1	molecular	molecular	ADJ
afs-72863	406	2	cloning	cloning	NOUN
afs-72863	406	3	and	and	CCONJ
afs-72863	406	4	sequence	sequence	NOUN
afs-72863	406	5	analysis	analysis	NOUN
afs-72863	406	6	of	of	ADP
afs-72863	406	7	the	the	DET
afs-72863	406	8	x	x	ADJ
afs-72863	406	9	-	-	ADJ
afs-72863	406	10	prolyl	prolyl	ADJ
afs-72863	406	11	dipeptidyl	dipeptidyl	NOUN
afs-72863	406	12	aminopeptidase	aminopeptidase	NOUN
afs-72863	406	13	gene	gene	NOUN
afs-72863	406	14	from	from	ADP
afs-72863	406	15	lactococcus	lactococcus	PROPN
afs-72863	406	16	lactis	lactis	PROPN
afs-72863	406	17	subsp	subsp	PROPN
afs-72863	406	18	.	.	PUNCT
afs-72863	407	1	cremoris	cremoris	PROPN
afs-72863	407	2	.	.	PUNCT
afs-72863	408	1	applied	apply	VERB
afs-72863	408	2	and	and	CCONJ
afs-72863	408	3	environmental	environmental	ADJ
afs-72863	408	4	microbiology57	microbiology57	NOUN
afs-72863	408	5	:	:	PUNCT
afs-72863	409	1	38	38	NUM
afs-72863	409	2	-	-	SYM
afs-72863	409	3	44	44	NUM
afs-72863	409	4	.	.	PUNCT
afs-72863	409	5	messner	messner	PROPN
afs-72863	409	6	,	,	PUNCT
afs-72863	409	7	p.	p.	PROPN
afs-72863	409	8	&	&	CCONJ
afs-72863	409	9	sleytr	sleytr	PROPN
afs-72863	409	10	,	,	PUNCT
afs-72863	409	11	u.b	u.b	PROPN
afs-72863	409	12	.	.	PROPN
afs-72863	409	13	1992	1992	NUM
afs-72863	409	14	.	.	PUNCT
afs-72863	410	1	crystalline	crystalline	PROPN
afs-72863	410	2	bacterial	bacterial	ADJ
afs-72863	410	3	cell	cell	NOUN
afs-72863	410	4	surface	surface	NOUN
afs-72863	410	5	layers	layer	NOUN
afs-72863	410	6	.	.	PUNCT
afs-72863	411	1	in	in	ADP
afs-72863	411	2	:	:	PUNCT
afs-72863	411	3	rose	rose	NOUN
afs-72863	411	4	,	,	PUNCT
afs-72863	411	5	a.h	a.h	PROPN
afs-72863	411	6	.	.	PROPN
afs-72863	411	7	(	(	PUNCT
afs-72863	411	8	ed	ed	NOUN
afs-72863	411	9	,	,	PUNCT
afs-72863	411	10	)	)	PUNCT
afs-72863	411	11	.	.	PUNCT
afs-72863	412	1	advances	advance	NOUN
afs-72863	412	2	in	in	ADP
afs-72863	412	3	microbialphysiology	microbialphysiology	NOUN
afs-72863	412	4	.	.	PUNCT
afs-72863	413	1	london	london	PROPN
afs-72863	413	2	:	:	PUNCT
afs-72863	413	3	academic	academic	ADJ
afs-72863	413	4	press	press	NOUN
afs-72863	413	5	,	,	PUNCT
afs-72863	413	6	p.	p.	NOUN
afs-72863	413	7	213275	213275	NUM
afs-72863	413	8	.	.	PUNCT
afs-72863	414	1	meyer	meyer	PROPN
afs-72863	414	2	-	-	PUNCT
afs-72863	414	3	barton	barton	PROPN
afs-72863	414	4	,	,	PUNCT
afs-72863	414	5	e.c	e.c	PROPN
afs-72863	414	6	.	.	PROPN
afs-72863	414	7	,	,	PUNCT
afs-72863	414	8	klein	klein	PROPN
afs-72863	414	9	,	,	PUNCT
afs-72863	414	10	j.r	j.r	PROPN
afs-72863	414	11	.	.	PROPN
afs-72863	414	12	,	,	PUNCT
afs-72863	414	13	imam	imam	PROPN
afs-72863	414	14	,	,	PUNCT
afs-72863	414	15	m.	m.	NOUN
afs-72863	414	16	&	&	CCONJ
afs-72863	414	17	plapp	plapp	PROPN
afs-72863	414	18	,	,	PUNCT
afs-72863	414	19	r.	r.	PROPN
afs-72863	414	20	1993	1993	NUM
afs-72863	414	21	.	.	PUNCT
afs-72863	415	1	cloning	cloning	NOUN
afs-72863	415	2	and	and	CCONJ
afs-72863	415	3	sequence	sequence	NOUN
afs-72863	415	4	analysis	analysis	NOUN
afs-72863	415	5	of	of	ADP
afs-72863	415	6	the	the	DET
afs-72863	415	7	x	x	ADJ
afs-72863	415	8	-	-	ADJ
afs-72863	415	9	prolyldipeptidyl	prolyldipeptidyl	ADJ
afs-72863	415	10	aminopeptidase	aminopeptidase	NOUN
afs-72863	415	11	gene	gene	NOUN
afs-72863	415	12	(	(	PUNCT
afs-72863	415	13	pepx	pepx	NOUN
afs-72863	415	14	)	)	PUNCT
afs-72863	415	15	from	from	ADP
afs-72863	415	16	lactobacillus	lactobacillus	NOUN
afs-72863	415	17	delbrueckii	delbrueckii	ADJ
afs-72863	415	18	subsp	subsp	NOUN
afs-72863	415	19	.	.	PUNCT
afs-72863	416	1	lactis	lactis	PROPN
afs-72863	416	2	dsm729o	dsm729o	PROPN
afs-72863	416	3	.	.	PUNCT
afs-72863	417	1	applied	apply	VERB
afs-72863	417	2	and	and	CCONJ
afs-72863	417	3	environmental	environmental	ADJ
afs-72863	417	4	microbiology	microbiology	NOUN
afs-72863	417	5	40	40	NUM
afs-72863	417	6	:	:	PUNCT
afs-72863	417	7	82	82	NUM
afs-72863	417	8	-	-	SYM
afs-72863	417	9	89	89	NUM
afs-72863	417	10	,	,	PUNCT
afs-72863	417	11	nardi	nardi	PROPN
afs-72863	417	12	,	,	PUNCT
afs-72863	417	13	m.	m.	NOUN
afs-72863	417	14	,	,	PUNCT
afs-72863	417	15	chopin	chopin	PROPN
afs-72863	417	16	,	,	PUNCT
afs-72863	417	17	m.-c	m.-c	NOUN
afs-72863	417	18	.	.	PUNCT
afs-72863	417	19	,	,	PUNCT
afs-72863	417	20	chopin	chopin	PROPN
afs-72863	417	21	,	,	PUNCT
afs-72863	417	22	a.	a.	NOUN
afs-72863	417	23	,	,	PUNCT
afs-72863	417	24	cals	cal	NOUN
afs-72863	417	25	,	,	PUNCT
afs-72863	417	26	m.-m	m.-m	PROPN
afs-72863	417	27	.	.	PUNCT
afs-72863	417	28	&	&	CCONJ
afs-72863	417	29	gripon	gripon	ADV
afs-72863	417	30	,	,	PUNCT
afs-72863	417	31	j.-c	j.-c	PROPN
afs-72863	417	32	.	.	PUNCT
afs-72863	417	33	1991	1991	NUM
afs-72863	417	34	.	.	PUNCT
afs-72863	418	1	cloning	cloning	NOUN
afs-72863	418	2	and	and	CCONJ
afs-72863	418	3	dna	dna	NOUN
afs-72863	418	4	sequence	sequence	NOUN
afs-72863	418	5	of	of	ADP
afs-72863	418	6	an	an	DET
afs-72863	418	7	x	x	ADJ
afs-72863	418	8	-	-	ADJ
afs-72863	418	9	prolyl	prolyl	ADJ
afs-72863	418	10	dipeptidyl	dipeptidyl	NOUN
afs-72863	418	11	aminopeptidase	aminopeptidase	NOUN
afs-72863	418	12	gene	gene	NOUN
afs-72863	418	13	from	from	ADP
afs-72863	418	14	lactococcus	lactococcus	PROPN
afs-72863	418	15	lactis	lactis	PROPN
afs-72863	418	16	subsp	subsp	NOUN
afs-72863	418	17	.	.	PUNCT
afs-72863	419	1	lactis	lactis	PROPN
afs-72863	419	2	ncdo	ncdo	ADP
afs-72863	419	3	763	763	NUM
afs-72863	419	4	.	.	PUNCT
afs-72863	420	1	applied	apply	VERB
afs-72863	420	2	and	and	CCONJ
afs-72863	420	3	environmental	environmental	ADJ
afs-72863	420	4	microbiology	microbiology	NOUN
afs-72863	420	5	57	57	NUM
afs-72863	420	6	:	:	PUNCT
afs-72863	420	7	45	45	NUM
afs-72863	420	8	-	-	SYM
afs-72863	420	9	50	50	NUM
afs-72863	420	10	.	.	PUNCT
afs-72863	421	1	nowakowski	nowakowski	PROPN
afs-72863	421	2	,	,	PUNCT
afs-72863	421	3	c.m	c.m	PROPN
afs-72863	421	4	.	.	PROPN
afs-72863	421	5	,	,	PUNCT
afs-72863	421	6	bhowmik	bhowmik	ADJ
afs-72863	421	7	,	,	PUNCT
afs-72863	421	8	t.k	t.k	PROPN
afs-72863	421	9	.	.	PROPN
afs-72863	421	10	&	&	CCONJ
afs-72863	421	11	steele	steele	PROPN
afs-72863	421	12	,	,	PUNCT
afs-72863	421	13	j.l	j.l	PROPN
afs-72863	421	14	.	.	PROPN
afs-72863	421	15	1993	1993	NUM
afs-72863	421	16	.	.	PUNCT
afs-72863	422	1	cloning	cloning	NOUN
afs-72863	422	2	of	of	ADP
afs-72863	422	3	peptidase	peptidase	NOUN
afs-72863	422	4	genes	gene	NOUN
afs-72863	422	5	from	from	ADP
afs-72863	422	6	lactobacillus	lactobacillus	ADJ
afs-72863	422	7	helveticus	helveticus	NOUN
afs-72863	422	8	cnrz32	cnrz32	NOUN
afs-72863	422	9	.	.	PUNCT
afs-72863	423	1	applied	apply	VERB
afs-72863	423	2	microbiology	microbiology	NOUN
afs-72863	423	3	and	and	CCONJ
afs-72863	423	4	biotechnology	biotechnology	NOUN
afs-72863	423	5	39	39	NUM
afs-72863	423	6	:	:	PUNCT
afs-72863	423	7	204	204	NUM
afs-72863	423	8	-	-	SYM
afs-72863	423	9	210	210	NUM
afs-72863	423	10	.	.	PUNCT
afs-72863	424	1	olson	olson	PROPN
afs-72863	424	2	,	,	PUNCT
afs-72863	424	3	n.f	n.f	PROPN
afs-72863	424	4	.	.	PROPN
afs-72863	424	5	1990	1990	NUM
afs-72863	424	6	.	.	PUNCT
afs-72863	425	1	the	the	DET
afs-72863	425	2	impact	impact	NOUN
afs-72863	425	3	of	of	ADP
afs-72863	425	4	lactic	lactic	ADJ
afs-72863	425	5	acid	acid	NOUN
afs-72863	425	6	bacteria	bacteria	NOUN
afs-72863	425	7	on	on	ADP
afs-72863	425	8	cheese	cheese	NOUN
afs-72863	425	9	flavour	flavour	NOUN
afs-72863	425	10	.	.	PUNCT
afs-72863	426	1	fems	fems	PROPN
afs-72863	426	2	microbiology	microbiology	NOUN
afs-72863	426	3	reviews	review	VERB
afs-72863	426	4	87	87	NUM
afs-72863	426	5	:	:	PUNCT
afs-72863	426	6	131	131	NUM
afs-72863	426	7	-	-	SYM
afs-72863	426	8	148	148	NUM
afs-72863	426	9	.	.	PUNCT
afs-72863	427	1	palva	palva	PROPN
afs-72863	427	2	,	,	PUNCT
afs-72863	427	3	a.	a.	PROPN
afs-72863	427	4	,	,	PUNCT
afs-72863	427	5	vidgrén	vidgrén	VERB
afs-72863	427	6	,	,	PUNCT
afs-72863	427	7	g.	g.	PROPN
afs-72863	427	8	,	,	PUNCT
afs-72863	427	9	palva	palva	NOUN
afs-72863	427	10	,	,	PUNCT
afs-72863	427	11	1	1	NUM
afs-72863	427	12	.	.	NUM
afs-72863	427	13	,	,	PUNCT
afs-72863	427	14	pakkanen	pakkanen	PROPN
afs-72863	427	15	,	,	PUNCT
afs-72863	427	16	r.	r.	PROPN
afs-72863	427	17	&	&	CCONJ
afs-72863	427	18	lounatmaa	lounatmaa	PROPN
afs-72863	427	19	,	,	PUNCT
afs-72863	427	20	k.	k.	PROPN
afs-72863	427	21	1992	1992	NUM
afs-72863	427	22	.	.	PUNCT
afs-72863	428	1	characterization	characterization	NOUN
afs-72863	428	2	of	of	ADP
afs-72863	428	3	expression	expression	NOUN
afs-72863	428	4	and	and	CCONJ
afs-72863	428	5	secretion	secretion	NOUN
afs-72863	428	6	signals	signal	NOUN
afs-72863	428	7	from	from	ADP
afs-72863	428	8	lactobacillus	lactobacillus	NOUN
afs-72863	428	9	brevis	brevis	NOUN
afs-72863	428	10	for	for	ADP
afs-72863	428	11	use	use	NOUN
afs-72863	428	12	in	in	ADP
afs-72863	428	13	food	food	NOUN
afs-72863	428	14	and	and	CCONJ
afs-72863	428	15	feed	feed	NOUN
afs-72863	428	16	industry	industry	NOUN
afs-72863	428	17	.	.	PUNCT
afs-72863	429	1	proceedings	proceeding	NOUN
afs-72863	429	2	of	of	ADP
afs-72863	429	3	sixth	sixth	ADJ
afs-72863	429	4	forum	forum	NOUN
afs-72863	429	5	for	for	ADP
afs-72863	429	6	applied	applied	ADJ
afs-72863	429	7	biotechnology	biotechnology	NOUN
afs-72863	429	8	.	.	PUNCT
afs-72863	430	1	med	med	PROPN
afs-72863	430	2	.	.	PUNCT
afs-72863	431	1	fac	fac	PROPN
afs-72863	431	2	.	.	PUNCT
afs-72863	432	1	landbouww	landbouww	PROPN
afs-72863	432	2	.	.	PUNCT
afs-72863	433	1	univ	univ	PROPN
afs-72863	433	2	.	.	PUNCT
afs-72863	433	3	gent	gent	PROPN
afs-72863	433	4	,	,	PUNCT
afs-72863	433	5	57/4b	57/4b	NOUN
afs-72863	433	6	.	.	PUNCT
afs-72863	434	1	p.	p.	NOUN
afs-72863	434	2	1891	1891	NUM
afs-72863	434	3	-	-	SYM
afs-72863	434	4	1898	1898	NUM
afs-72863	434	5	.	.	PUNCT
afs-72863	435	1	pot	pot	NOUN
afs-72863	435	2	,	,	PUNCT
afs-72863	435	3	b	b	NOUN
afs-72863	435	4	„	„	PUNCT
afs-72863	435	5	ludwig	ludwig	PROPN
afs-72863	435	6	,	,	PUNCT
afs-72863	435	7	w	w	PROPN
afs-72863	435	8	„	„	PUNCT
afs-72863	435	9	kersters	kerster	NOUN
afs-72863	435	10	,	,	PUNCT
afs-72863	435	11	k.	k.	PROPN
afs-72863	435	12	&	&	CCONJ
afs-72863	435	13	schleifer	schleifer	PROPN
afs-72863	435	14	,	,	PUNCT
afs-72863	435	15	k.-h	k.-h	PROPN
afs-72863	435	16	.	.	PUNCT
afs-72863	435	17	1994	1994	NUM
afs-72863	435	18	.	.	PUNCT
afs-72863	436	1	taxonomy	taxonomy	NOUN
afs-72863	436	2	of	of	ADP
afs-72863	436	3	lactic	lactic	ADJ
afs-72863	436	4	acid	acid	NOUN
afs-72863	436	5	bacteria	bacteria	NOUN
afs-72863	436	6	.	.	PUNCT
afs-72863	437	1	in	in	ADP
afs-72863	437	2	:	:	PUNCT
afs-72863	437	3	de	de	PROPN
afs-72863	437	4	vuyst	vuyst	NOUN
afs-72863	437	5	,	,	PUNCT
afs-72863	437	6	l.	l.	PROPN
afs-72863	437	7	&	&	CCONJ
afs-72863	437	8	vandamme	vandamme	PROPN
afs-72863	437	9	,	,	PUNCT
afs-72863	437	10	e.j	e.j	PROPN
afs-72863	437	11	.	.	PROPN
afs-72863	437	12	(	(	PUNCT
afs-72863	437	13	eds	ed	NOUN
afs-72863	437	14	.	.	PUNCT
afs-72863	437	15	)	)	PUNCT
afs-72863	437	16	.	.	PUNCT
afs-72863	438	1	bacteriocins	bacteriocin	NOUN
afs-72863	438	2	of	of	ADP
afs-72863	438	3	lactic	lactic	ADJ
afs-72863	438	4	acid	acid	NOUN
afs-72863	438	5	bacteria	bacteria	NOUN
afs-72863	438	6	.	.	PUNCT
afs-72863	439	1	london	london	PROPN
afs-72863	439	2	:	:	PUNCT
afs-72863	439	3	blackie	blackie	NOUN
afs-72863	439	4	academic	academic	PROPN
afs-72863	439	5	&	&	CCONJ
afs-72863	439	6	professional	professional	PROPN
afs-72863	439	7	,	,	PUNCT
afs-72863	439	8	p.	p.	NOUN
afs-72863	439	9	13	13	NUM
afs-72863	439	10	-	-	SYM
afs-72863	439	11	90	90	NUM
afs-72863	439	12	.	.	PUNCT
afs-72863	439	13	rantanen	rantanen	NOUN
afs-72863	439	14	,	,	PUNCT
afs-72863	439	15	t.	t.	PROPN
afs-72863	439	16	&	&	CCONJ
afs-72863	439	17	palva	palva	PROPN
afs-72863	439	18	,	,	PUNCT
afs-72863	439	19	a.	a.	NOUN
afs-72863	439	20	1997	1997	NUM
afs-72863	439	21	.	.	PUNCT
afs-72863	440	1	lactobacilli	lactobacilli	PROPN
afs-72863	440	2	carry	carry	VERB
afs-72863	440	3	cryptic	cryptic	ADJ
afs-72863	440	4	genes	gene	NOUN
afs-72863	440	5	encoding	encode	VERB
afs-72863	440	6	peptidase	peptidase	NOUN
afs-72863	440	7	-	-	PUNCT
afs-72863	440	8	related	relate	VERB
afs-72863	440	9	proteins	protein	NOUN
afs-72863	440	10	:	:	PUNCT
afs-72863	440	11	characterization	characterization	NOUN
afs-72863	440	12	of	of	ADP
afs-72863	440	13	a	a	DET
afs-72863	440	14	prolidase	prolidase	NOUN
afs-72863	440	15	gene	gene	NOUN
afs-72863	440	16	(	(	PUNCT
afs-72863	440	17	pepo	pepo	NOUN
afs-72863	440	18	)	)	PUNCT
afs-72863	440	19	and	and	CCONJ
afs-72863	440	20	a	a	DET
afs-72863	440	21	related	relate	VERB
afs-72863	440	22	cryptic	cryptic	ADJ
afs-72863	440	23	gene	gene	NOUN
afs-72863	440	24	(	(	PUNCT
afs-72863	440	25	orfz	orfz	NOUN
afs-72863	440	26	)	)	PUNCT
afs-72863	440	27	from	from	ADP
afs-72863	440	28	lactobacillus	lactobacillus	NOUN
afs-72863	440	29	delbrueckii	delbrueckii	ADJ
afs-72863	440	30	subsp	subsp	NOUN
afs-72863	440	31	.	.	PUNCT
afs-72863	441	1	bulgaricus	bulgaricus	NOUN
afs-72863	441	2	.	.	PUNCT
afs-72863	442	1	microbiology	microbiology	NOUN
afs-72863	442	2	143	143	NUM
afs-72863	442	3	:	:	PUNCT
afs-72863	442	4	3899	3899	NUM
afs-72863	442	5	-	-	SYM
afs-72863	442	6	3905	3905	NUM
afs-72863	442	7	.	.	PUNCT
afs-72863	443	1	salminen	salminen	PROPN
afs-72863	443	2	,	,	PUNCT
afs-72863	443	3	s.	s.	PROPN
afs-72863	443	4	,	,	PUNCT
afs-72863	443	5	isolauri	isolauri	PROPN
afs-72863	443	6	,	,	PUNCT
afs-72863	443	7	e.	e.	PROPN
afs-72863	443	8	&	&	CCONJ
afs-72863	443	9	salminen	salminen	PROPN
afs-72863	443	10	,	,	PUNCT
afs-72863	443	11	e.	e.	PROPN
afs-72863	443	12	1996	1996	NUM
afs-72863	443	13	.	.	PUNCT
afs-72863	444	1	clinical	clinical	ADJ
afs-72863	444	2	uses	use	NOUN
afs-72863	444	3	of	of	ADP
afs-72863	444	4	probiotics	probiotic	NOUN
afs-72863	444	5	for	for	ADP
afs-72863	444	6	stabilizing	stabilize	VERB
afs-72863	444	7	the	the	DET
afs-72863	444	8	gut	gut	NOUN
afs-72863	444	9	mucosal	mucosal	NOUN
afs-72863	444	10	barrier	barrier	NOUN
afs-72863	444	11	:	:	PUNCT
afs-72863	444	12	successful	successful	ADJ
afs-72863	444	13	strains	strain	NOUN
afs-72863	444	14	and	and	CCONJ
afs-72863	444	15	future	future	ADJ
afs-72863	444	16	challenges	challenge	NOUN
afs-72863	444	17	.	.	PUNCT
afs-72863	445	1	antonie	antonie	PROPN
afs-72863	445	2	van	van	PROPN
afs-72863	445	3	leeuwenhoek	leeuwenhoek	PROPN
afs-72863	445	4	70	70	NUM
afs-72863	445	5	:	:	PUNCT
afs-72863	445	6	347	347	NUM
afs-72863	445	7	-	-	SYM
afs-72863	445	8	358	358	NUM
afs-72863	445	9	.	.	PUNCT
afs-72863	446	1	savijoki	savijoki	NOUN
afs-72863	446	2	,	,	PUNCT
afs-72863	446	3	k.	k.	PROPN
afs-72863	446	4	,	,	PUNCT
afs-72863	446	5	kahala	kahala	PROPN
afs-72863	446	6	,	,	PUNCT
afs-72863	446	7	m.	m.	NOUN
afs-72863	446	8	&	&	CCONJ
afs-72863	446	9	palva	palva	PROPN
afs-72863	446	10	,	,	PUNCT
afs-72863	446	11	a.	a.	NOUN
afs-72863	446	12	1997	1997	NUM
afs-72863	446	13	.	.	PUNCT
afs-72863	447	1	high	high	ADJ
afs-72863	447	2	level	level	NOUN
afs-72863	447	3	heterologous	heterologous	ADJ
afs-72863	447	4	protein	protein	NOUN
afs-72863	447	5	production	production	NOUN
afs-72863	447	6	in	in	ADP
afs-72863	447	7	lactococcus	lactococcus	PROPN
afs-72863	447	8	and	and	CCONJ
afs-72863	447	9	lactobacillus	lactobacillus	NOUN
afs-72863	447	10	using	use	VERB
afs-72863	447	11	a	a	DET
afs-72863	447	12	new	new	ADJ
afs-72863	447	13	secretion	secretion	NOUN
afs-72863	447	14	system	system	NOUN
afs-72863	447	15	based	base	VERB
afs-72863	447	16	on	on	ADP
afs-72863	447	17	the	the	DET
afs-72863	447	18	lactobacillus	lactobacillus	NOUN
afs-72863	447	19	brevis	brevis	NOUN
afs-72863	447	20	s	s	NOUN
afs-72863	447	21	-	-	PUNCT
afs-72863	447	22	layer	layer	NOUN
afs-72863	447	23	signals	signal	NOUN
afs-72863	447	24	.	.	PUNCT
afs-72863	448	1	gene	gene	NOUN
afs-72863	448	2	186	186	NUM
afs-72863	448	3	:	:	PUNCT
afs-72863	448	4	255	255	NUM
afs-72863	448	5	-	-	SYM
afs-72863	448	6	262	262	NUM
afs-72863	448	7	.	.	PUNCT
afs-72863	449	1	schleifer	schleifer	VERB
afs-72863	449	2	,	,	PUNCT
afs-72863	449	3	k.h	k.h	PROPN
afs-72863	449	4	.	.	PROPN
afs-72863	449	5	&	&	CCONJ
afs-72863	449	6	ludwig	ludwig	PROPN
afs-72863	449	7	,	,	PUNCT
afs-72863	449	8	w.	w.	PROPN
afs-72863	449	9	1995	1995	NUM
afs-72863	449	10	.	.	PUNCT
afs-72863	450	1	phylogeneticrelationship	phylogeneticrelationship	NOUN
afs-72863	450	2	of	of	ADP
afs-72863	450	3	lactic	lactic	ADJ
afs-72863	450	4	acid	acid	NOUN
afs-72863	450	5	bacteria	bacteria	NOUN
afs-72863	450	6	.	.	PUNCT
afs-72863	451	1	in	in	ADP
afs-72863	451	2	:	:	PUNCT
afs-72863	451	3	wood	wood	NOUN
afs-72863	451	4	,	,	PUNCT
afs-72863	451	5	8.j.8	8.j.8	NOUN
afs-72863	451	6	.	.	PUNCT
afs-72863	452	1	&	&	CCONJ
afs-72863	452	2	holzapfel	holzapfel	PROPN
afs-72863	452	3	,	,	PUNCT
afs-72863	452	4	w.h	w.h	PROPN
afs-72863	452	5	.	.	PROPN
afs-72863	452	6	(	(	PUNCT
afs-72863	452	7	eds	ed	NOUN
afs-72863	452	8	.	.	PUNCT
afs-72863	452	9	)	)	PUNCT
afs-72863	453	1	the	the	DET
afs-72863	453	2	genera	genera	NOUN
afs-72863	453	3	of	of	ADP
afs-72863	453	4	lactic	lactic	ADJ
afs-72863	453	5	acid	acid	NOUN
afs-72863	453	6	bacteria	bacteria	NOUN
afs-72863	453	7	.	.	PUNCT
afs-72863	454	1	london	london	PROPN
afs-72863	454	2	:	:	PUNCT
afs-72863	454	3	blackie	blackie	NOUN
afs-72863	454	4	academic	academic	PROPN
afs-72863	454	5	&	&	CCONJ
afs-72863	454	6	professional	professional	PROPN
afs-72863	454	7	,	,	PUNCT
afs-72863	454	8	p.	p.	NOUN
afs-72863	454	9	718	718	NUM
afs-72863	454	10	.	.	PUNCT
afs-72863	455	1	sibakov	sibakov	NOUN
afs-72863	455	2	,	,	PUNCT
afs-72863	455	3	m.	m.	NOUN
afs-72863	455	4	,	,	PUNCT
afs-72863	455	5	koivula	koivula	PROPN
afs-72863	455	6	,	,	PUNCT
afs-72863	455	7	t	t	PROPN
afs-72863	455	8	,	,	PUNCT
afs-72863	455	9	von	von	PROPN
afs-72863	455	10	wright	wright	PROPN
afs-72863	455	11	,	,	PUNCT
afs-72863	455	12	a.	a.	PROPN
afs-72863	455	13	&	&	CCONJ
afs-72863	455	14	palva	palva	PROPN
afs-72863	455	15	,	,	PUNCT
afs-72863	455	16	i.	i.	PROPN
afs-72863	455	17	1991	1991	NUM
afs-72863	455	18	.	.	PUNCT
afs-72863	456	1	secretion	secretion	NOUN
afs-72863	456	2	of	of	ADP
afs-72863	456	3	tem	tem	PROPN
afs-72863	456	4	b	b	PROPN
afs-72863	456	5	-	-	PUNCT
afs-72863	456	6	lactamase	lactamase	NOUN
afs-72863	456	7	with	with	ADP
afs-72863	456	8	signal	signal	ADJ
afs-72863	456	9	sequences	sequence	NOUN
afs-72863	456	10	isolated	isolate	VERB
afs-72863	456	11	from	from	ADP
afs-72863	456	12	the	the	DET
afs-72863	456	13	chromosome	chromosome	NOUN
afs-72863	456	14	of	of	ADP
afs-72863	456	15	lactococcus	lactococcus	PROPN
afs-72863	456	16	lactis	lactis	PROPN
afs-72863	456	17	subsp	subsp	NOUN
afs-72863	456	18	.	.	PUNCT
afs-72863	457	1	lactis	lactis	PROPN
afs-72863	457	2	.	.	PUNCT
afs-72863	457	3	applied	apply	VERB
afs-72863	457	4	and	and	CCONJ
afs-72863	457	5	environmental	environmental	ADJ
afs-72863	457	6	microbiology	microbiology	NOUN
afs-72863	457	7	57	57	NUM
afs-72863	457	8	:	:	PUNCT
afs-72863	457	9	341	341	NUM
afs-72863	457	10	-	-	SYM
afs-72863	457	11	348	348	NUM
afs-72863	457	12	.	.	PUNCT
afs-72863	458	1	simonen	simonen	PROPN
afs-72863	458	2	,	,	PUNCT
afs-72863	458	3	m.	m.	NOUN
afs-72863	458	4	&	&	CCONJ
afs-72863	458	5	palva	palva	PROPN
afs-72863	458	6	,	,	PUNCT
afs-72863	458	7	i.	i.	PROPN
afs-72863	458	8	1993	1993	NUM
afs-72863	458	9	.	.	PUNCT
afs-72863	459	1	protein	protein	NOUN
afs-72863	459	2	secretion	secretion	NOUN
afs-72863	459	3	in	in	ADP
afs-72863	459	4	bacillus	bacillus	NOUN
afs-72863	459	5	species	specie	NOUN
afs-72863	459	6	.	.	PUNCT
afs-72863	460	1	microbiology	microbiology	NOUN
afs-72863	460	2	reviews	review	VERB
afs-72863	460	3	57	57	NUM
afs-72863	460	4	:	:	SYM
afs-72863	460	5	109	109	NUM
afs-72863	460	6	-	-	SYM
afs-72863	460	7	137	137	NUM
afs-72863	460	8	.	.	PUNCT
afs-72863	461	1	tan	tan	PROPN
afs-72863	461	2	,	,	PUNCT
afs-72863	461	3	p	p	X
afs-72863	461	4	,	,	PUNCT
afs-72863	461	5	,	,	PUNCT
afs-72863	461	6	van	van	PROPN
afs-72863	461	7	alen	alen	PROPN
afs-72863	461	8	-	-	PUNCT
afs-72863	461	9	boerrigter	boerrigter	NOUN
afs-72863	461	10	,	,	PUNCT
afs-72863	461	11	1	1	NUM
afs-72863	461	12	.	.	NUM
afs-72863	461	13	,	,	PUNCT
afs-72863	461	14	poolman	poolman	NOUN
afs-72863	461	15	,	,	PUNCT
afs-72863	461	16	b	b	NOUN
afs-72863	461	17	,	,	PUNCT
afs-72863	461	18	siezen	siezen	ADJ
afs-72863	461	19	,	,	PUNCT
afs-72863	461	20	r.	r.	PROPN
afs-72863	461	21	,	,	PUNCT
afs-72863	461	22	de	de	X
afs-72863	461	23	vos	vos	PROPN
afs-72863	461	24	,	,	PUNCT
afs-72863	461	25	w.	w.	PROPN
afs-72863	461	26	&	&	CCONJ
afs-72863	461	27	konings	konings	PROPN
afs-72863	461	28	,	,	PUNCT
afs-72863	461	29	w.	w.	PROPN
afs-72863	461	30	1992	1992	NUM
afs-72863	461	31	.	.	PUNCT
afs-72863	462	1	characterization	characterization	NOUN
afs-72863	462	2	of	of	ADP
afs-72863	462	3	the	the	DET
afs-72863	462	4	lactococcus	lactococcus	NOUN
afs-72863	462	5	lactis	lactis	PROPN
afs-72863	462	6	pepnencoding	pepnencode	VERB
afs-72863	462	7	an	an	DET
afs-72863	462	8	aminopeptidase	aminopeptidase	NOUN
afs-72863	462	9	homologous	homologous	ADJ
afs-72863	462	10	to	to	ADP
afs-72863	462	11	mammalian	mammalian	ADJ
afs-72863	462	12	aminopeptidase	aminopeptidase	PROPN
afs-72863	462	13	n.	n.	PROPN
afs-72863	462	14	febs	febs	PROPN
afs-72863	462	15	letters	letter	NOUN
afs-72863	462	16	306	306	NUM
afs-72863	462	17	:	:	PUNCT
afs-72863	462	18	9	9	NUM
afs-72863	462	19	-	-	SYM
afs-72863	462	20	16	16	NUM
afs-72863	462	21	.	.	PUNCT
afs-72863	463	1	tannock	tannock	PROPN
afs-72863	463	2	,	,	PUNCT
afs-72863	463	3	g.w	g.w	PROPN
afs-72863	463	4	.	.	PROPN
afs-72863	463	5	1995	1995	NUM
afs-72863	463	6	.	.	PUNCT
afs-72863	464	1	microecology	microecology	NOUN
afs-72863	464	2	of	of	ADP
afs-72863	464	3	the	the	DET
afs-72863	464	4	gastrointestinal	gastrointestinal	ADJ
afs-72863	464	5	tract	tract	NOUN
afs-72863	464	6	in	in	ADP
afs-72863	464	7	relation	relation	NOUN
afs-72863	464	8	to	to	ADP
afs-72863	464	9	lactic	lactic	ADJ
afs-72863	464	10	acid	acid	NOUN
afs-72863	464	11	bacteria	bacteria	NOUN
afs-72863	464	12	.	.	PUNCT
afs-72863	465	1	international	international	ADJ
afs-72863	465	2	dairy	dairy	NOUN
afs-72863	465	3	journal	journal	NOUN
afs-72863	465	4	5	5	NUM
afs-72863	465	5	;	;	PUNCT
afs-72863	465	6	1059	1059	NUM
afs-72863	465	7	-	-	SYM
afs-72863	465	8	1070	1070	NUM
afs-72863	465	9	.	.	PUNCT
afs-72863	466	1	toba	toba	PROPN
afs-72863	466	2	,	,	PUNCT
afs-72863	466	3	t	t	PROPN
afs-72863	466	4	,	,	PUNCT
afs-72863	466	5	virkola	virkola	PROPN
afs-72863	466	6	,	,	PUNCT
afs-72863	466	7	r.	r.	PROPN
afs-72863	466	8	,	,	PUNCT
afs-72863	466	9	westerlund	westerlund	PROPN
afs-72863	466	10	,	,	PUNCT
afs-72863	466	11	8	8	NUM
afs-72863	466	12	.	.	NUM
afs-72863	466	13	,	,	PUNCT
afs-72863	466	14	björkman	björkman	NOUN
afs-72863	466	15	,	,	PUNCT
afs-72863	466	16	y.	y.	NOUN
afs-72863	466	17	,	,	PUNCT
afs-72863	466	18	sillanpää	sillanpää	NOUN
afs-72863	466	19	,	,	PUNCT
afs-72863	466	20	j.	j.	PROPN
afs-72863	466	21	,	,	PUNCT
afs-72863	466	22	vartio	vartio	PROPN
afs-72863	466	23	,	,	PUNCT
afs-72863	466	24	t	t	PROPN
afs-72863	466	25	,	,	PUNCT
afs-72863	466	26	kalkkinen	kalkkinen	PROPN
afs-72863	466	27	,	,	PUNCT
afs-72863	466	28	n.	n.	PROPN
afs-72863	466	29	&	&	CCONJ
afs-72863	466	30	korhonen	korhonen	PROPN
afs-72863	466	31	,	,	PUNCT
afs-72863	466	32	t.	t.	PROPN
afs-72863	466	33	1995	1995	NUM
afs-72863	466	34	.	.	PUNCT
afs-72863	467	1	a	a	DET
afs-72863	467	2	collagen	collagen	NOUN
afs-72863	467	3	-	-	PUNCT
afs-72863	467	4	binding	bind	VERB
afs-72863	467	5	s	s	NOUN
afs-72863	467	6	-	-	PUNCT
afs-72863	467	7	layer	layer	NOUN
afs-72863	467	8	protein	protein	NOUN
afs-72863	467	9	in	in	ADP
afs-72863	467	10	lacto280	lacto280	PROPN
afs-72863	467	11	seminar	seminar	NOUN
afs-72863	467	12	in	in	ADP
afs-72863	467	13	honour	honour	NOUN
afs-72863	467	14	of	of	ADP
afs-72863	467	15	the	the	DET
afs-72863	467	16	100th	100th	ADJ
afs-72863	467	17	anniversary	anniversary	NOUN
afs-72863	467	18	ofmtt	ofmtt	NOUN
afs-72863	467	19	agricultural	agricultural	ADJ
afs-72863	467	20	and	and	CCONJ
afs-72863	467	21	food	food	NOUN
afs-72863	467	22	science	science	NOUN
afs-72863	467	23	in	in	ADP
afs-72863	467	24	finland	finland	PROPN
afs-72863	467	25	bacillus	bacillus	NOUN
afs-72863	467	26	crispatus	crispatus	NOUN
afs-72863	467	27	.	.	PUNCT
afs-72863	468	1	appliedand	appliedand	NOUN
afs-72863	468	2	environmental	environmental	ADJ
afs-72863	468	3	microbiology	microbiology	NOUN
afs-72863	468	4	61	61	NUM
afs-72863	468	5	:	:	PUNCT
afs-72863	468	6	2467	2467	NUM
afs-72863	468	7	-	-	SYM
afs-72863	468	8	2471	2471	NUM
afs-72863	468	9	.	.	PUNCT
afs-72863	469	1	tynkkynen	tynkkynen	NOUN
afs-72863	469	2	,	,	PUNCT
afs-72863	469	3	s.	s.	PROPN
afs-72863	469	4	,	,	PUNCT
afs-72863	469	5	buist	buist	NOUN
afs-72863	469	6	,	,	PUNCT
afs-72863	469	7	g.	g.	PROPN
afs-72863	469	8	,	,	PUNCT
afs-72863	469	9	kunji	kunji	X
afs-72863	469	10	,	,	PUNCT
afs-72863	469	11	e.	e.	PROPN
afs-72863	469	12	,	,	PUNCT
afs-72863	469	13	kok	kok	PROPN
afs-72863	469	14	,	,	PUNCT
afs-72863	469	15	j.	j.	PROPN
afs-72863	469	16	,	,	PUNCT
afs-72863	469	17	poolman	poolman	NOUN
afs-72863	469	18	,	,	PUNCT
afs-72863	469	19	8	8	NUM
afs-72863	469	20	.	.	NUM
afs-72863	469	21	,	,	PUNCT
afs-72863	469	22	venema	venema	NOUN
afs-72863	469	23	,	,	PUNCT
afs-72863	469	24	g.	g.	PROPN
afs-72863	469	25	&	&	CCONJ
afs-72863	469	26	haandrikman	haandrikman	PROPN
afs-72863	469	27	,	,	PUNCT
afs-72863	469	28	a.j	a.j	PROPN
afs-72863	469	29	.	.	PROPN
afs-72863	469	30	1993	1993	NUM
afs-72863	469	31	.	.	PUNCT
afs-72863	470	1	genetic	genetic	ADJ
afs-72863	470	2	and	and	CCONJ
afs-72863	470	3	biochemical	biochemical	ADJ
afs-72863	470	4	characterization	characterization	NOUN
afs-72863	470	5	of	of	ADP
afs-72863	470	6	the	the	DET
afs-72863	470	7	oligopeptide	oligopeptide	NOUN
afs-72863	470	8	transport	transport	NOUN
afs-72863	470	9	system	system	NOUN
afs-72863	470	10	of	of	ADP
afs-72863	470	11	lactococcus	lactococcus	PROPN
afs-72863	470	12	lactis	lactis	PROPN
afs-72863	470	13	.	.	PUNCT
afs-72863	471	1	journal	journal	PROPN
afs-72863	471	2	of	of	ADP
afs-72863	471	3	bacteriology	bacteriology	NOUN
afs-72863	471	4	175	175	NUM
afs-72863	471	5	:	:	PUNCT
afs-72863	471	6	7523	7523	NUM
afs-72863	471	7	-	-	SYM
afs-72863	471	8	7532	7532	NUM
afs-72863	471	9	.	.	PUNCT
afs-72863	472	1	varmanen	varmanen	NOUN
afs-72863	472	2	,	,	PUNCT
afs-72863	472	3	p.	p.	NOUN
afs-72863	472	4	,	,	PUNCT
afs-72863	472	5	rantanen	rantanen	PROPN
afs-72863	472	6	,	,	PUNCT
afs-72863	472	7	r.	r.	PROPN
afs-72863	472	8	&	&	CCONJ
afs-72863	472	9	palva	palva	PROPN
afs-72863	472	10	,	,	PUNCT
afs-72863	472	11	a.	a.	NOUN
afs-72863	472	12	1996b	1996b	NUM
afs-72863	472	13	.	.	PUNCT
afs-72863	473	1	an	an	DET
afs-72863	473	2	operon	operon	NOUN
afs-72863	473	3	from	from	ADP
afs-72863	473	4	lactobacillus	lactobacillus	NOUN
afs-72863	473	5	hetveticus	hetveticus	NOUN
afs-72863	473	6	composed	compose	VERB
afs-72863	473	7	of	of	ADP
afs-72863	473	8	a	a	DET
afs-72863	473	9	proline	proline	NOUN
afs-72863	473	10	iminopeptidase	iminopeptidase	NOUN
afs-72863	473	11	gene	gene	NOUN
afs-72863	473	12	(	(	PUNCT
afs-72863	473	13	pept	pept	PROPN
afs-72863	473	14	)	)	PUNCT
afs-72863	473	15	and	and	CCONJ
afs-72863	473	16	two	two	NUM
afs-72863	473	17	genes	gene	NOUN
afs-72863	473	18	coding	code	VERB
afs-72863	473	19	for	for	ADP
afs-72863	473	20	putative	putative	ADJ
afs-72863	473	21	members	member	NOUN
afs-72863	473	22	of	of	ADP
afs-72863	473	23	the	the	DET
afs-72863	473	24	abc	abc	PROPN
afs-72863	473	25	transporter	transporter	NOUN
afs-72863	473	26	family	family	NOUN
afs-72863	473	27	of	of	ADP
afs-72863	473	28	proteins	protein	NOUN
afs-72863	473	29	.	.	PUNCT
afs-72863	474	1	microbiolgy	microbiolgy	NOUN
afs-72863	474	2	142	142	NUM
afs-72863	474	3	:	:	PUNCT
afs-72863	474	4	3459	3459	NUM
afs-72863	474	5	-	-	SYM
afs-72863	474	6	3468	3468	NUM
afs-72863	474	7	.	.	PUNCT
afs-72863	475	1	,	,	PUNCT
afs-72863	475	2	steele	steele	PROPN
afs-72863	475	3	,	,	PUNCT
afs-72863	475	4	j.	j.	PROPN
afs-72863	475	5	&	&	CCONJ
afs-72863	475	6	palva	palva	PROPN
afs-72863	475	7	,	,	PUNCT
afs-72863	475	8	a.	a.	NOUN
afs-72863	475	9	1996a	1996a	NUM
afs-72863	475	10	.	.	PUNCT
afs-72863	476	1	characterization	characterization	NOUN
afs-72863	476	2	of	of	ADP
afs-72863	476	3	a	a	DET
afs-72863	476	4	prolinase	prolinase	NOUN
afs-72863	476	5	gene	gene	NOUN
afs-72863	476	6	and	and	CCONJ
afs-72863	476	7	its	its	PRON
afs-72863	476	8	product	product	NOUN
afs-72863	476	9	and	and	CCONJ
afs-72863	476	10	an	an	DET
afs-72863	476	11	adjacentabc	adjacentabc	NOUN
afs-72863	476	12	transporter	transporter	VERB
afs-72863	476	13	from	from	ADP
afs-72863	476	14	lactobacillus	lactobacillus	NOUN
afs-72863	476	15	hetveticus	hetveticus	NOUN
afs-72863	476	16	.	.	PUNCT
afs-72863	477	1	microbiology	microbiology	NOUN
afs-72863	477	2	142	142	NUM
afs-72863	477	3	:	:	PUNCT
afs-72863	477	4	809	809	NUM
afs-72863	477	5	-	-	SYM
afs-72863	477	6	816	816	NUM
afs-72863	477	7	.	.	PUNCT
afs-72863	477	8	,	,	PUNCT
afs-72863	477	9	vesanto	vesanto	ADP
afs-72863	477	10	,	,	PUNCT
afs-72863	477	11	e.	e.	PROPN
afs-72863	477	12	,	,	PUNCT
afs-72863	477	13	steele	steele	PROPN
afs-72863	477	14	,	,	PUNCT
afs-72863	477	15	j.	j.	PROPN
afs-72863	477	16	&	&	CCONJ
afs-72863	477	17	palva	palva	PROPN
afs-72863	477	18	,	,	PUNCT
afs-72863	477	19	a.	a.	NOUN
afs-72863	477	20	1994	1994	NUM
afs-72863	477	21	.	.	PUNCT
afs-72863	478	1	characterization	characterization	NOUN
afs-72863	478	2	and	and	CCONJ
afs-72863	478	3	expression	expression	NOUN
afs-72863	478	4	of	of	ADP
afs-72863	478	5	the	the	DET
afs-72863	478	6	pepn	pepn	PROPN
afs-72863	478	7	gene	gene	NOUN
afs-72863	478	8	encoding	encode	VERB
afs-72863	478	9	a	a	DET
afs-72863	478	10	general	general	ADJ
afs-72863	478	11	aminopeptidase	aminopeptidase	NOUN
afs-72863	478	12	from	from	ADP
afs-72863	478	13	lactobacillus	lactobacillus	NOUN
afs-72863	478	14	hetveticus	hetveticus	NOUN
afs-72863	478	15	.	.	PUNCT
afs-72863	479	1	fems	fems	PROPN
afs-72863	479	2	microbiologyletters	microbiologyletter	NOUN
afs-72863	479	3	124	124	NUM
afs-72863	479	4	:	:	PUNCT
afs-72863	479	5	315	315	NUM
afs-72863	479	6	-	-	SYM
afs-72863	479	7	320	320	NUM
afs-72863	479	8	.	.	PUNCT
afs-72863	479	9	venema	venema	PROPN
afs-72863	479	10	,	,	PUNCT
afs-72863	479	11	g.	g.	PROPN
afs-72863	479	12	,	,	PUNCT
afs-72863	479	13	huis	huis	PROPN
afs-72863	479	14	in’t	in’t	PROPN
afs-72863	479	15	veld	veld	PROPN
afs-72863	479	16	,	,	PUNCT
afs-72863	479	17	j.h.j	j.h.j	PROPN
afs-72863	479	18	.	.	PROPN
afs-72863	479	19	&	&	CCONJ
afs-72863	479	20	hugenholtz	hugenholtz	PROPN
afs-72863	479	21	,	,	PUNCT
afs-72863	479	22	j.	j.	PROPN
afs-72863	479	23	(	(	PUNCT
afs-72863	479	24	eds	eds	PROPN
afs-72863	479	25	.	.	PUNCT
afs-72863	479	26	)	)	PUNCT
afs-72863	479	27	.	.	PUNCT
afs-72863	480	1	1996	1996	NUM
afs-72863	480	2	.	.	PUNCT
afs-72863	481	1	lactic	lactic	ADJ
afs-72863	481	2	acid	acid	NOUN
afs-72863	481	3	bacteria	bacteria	NOUN
afs-72863	481	4	:	:	PUNCT
afs-72863	481	5	genetics	genetic	NOUN
afs-72863	481	6	,	,	PUNCT
afs-72863	481	7	metabolism	metabolism	NOUN
afs-72863	481	8	and	and	CCONJ
afs-72863	481	9	applications	application	NOUN
afs-72863	481	10	.	.	PUNCT
afs-72863	482	1	proceedings	proceeding	NOUN
afs-72863	482	2	of	of	ADP
afs-72863	482	3	the	the	DET
afs-72863	482	4	fifth	fifth	ADJ
afs-72863	482	5	symposium	symposium	NOUN
afs-72863	482	6	on	on	ADP
afs-72863	482	7	lactic	lactic	ADJ
afs-72863	482	8	acid	acid	NOUN
afs-72863	482	9	bacteria	bacteria	NOUN
afs-72863	482	10	.	.	PUNCT
afs-72863	483	1	veldhoven	veldhoven	PROPN
afs-72863	483	2	,	,	PUNCT
afs-72863	483	3	the	the	DET
afs-72863	483	4	netherlands	netherlands	PROPN
afs-72863	483	5	,	,	PUNCT
afs-72863	483	6	8	8	NUM
afs-72863	483	7	-	-	SYM
afs-72863	483	8	12	12	NUM
afs-72863	483	9	september	september	PROPN
afs-72863	483	10	1996	1996	NUM
afs-72863	483	11	.	.	PUNCT
afs-72863	484	1	antonie	antonie	PROPN
afs-72863	484	2	van	van	PROPN
afs-72863	484	3	leeuwenhoekto	leeuwenhoekto	PROPN
afs-72863	484	4	.	.	PUNCT
afs-72863	485	1	358	358	NUM
afs-72863	485	2	p.	p.	NOUN
afs-72863	485	3	dordrecht	dordrecht	PROPN
afs-72863	485	4	:	:	PUNCT
afs-72863	485	5	kluwer	kluwer	NOUN
afs-72863	485	6	academic	academic	ADJ
afs-72863	485	7	publishers	publisher	NOUN
afs-72863	485	8	.	.	PUNCT
afs-72863	486	1	vesanto	vesanto	ADP
afs-72863	486	2	,	,	PUNCT
afs-72863	486	3	e.	e.	PROPN
afs-72863	486	4	,	,	PUNCT
afs-72863	486	5	peltoniemi	peltoniemi	PROPN
afs-72863	486	6	,	,	PUNCT
afs-72863	486	7	k.	k.	PROPN
afs-72863	486	8	,	,	PUNCT
afs-72863	486	9	purtsi	purtsi	PROPN
afs-72863	486	10	,	,	PUNCT
afs-72863	486	11	t.	t.	PROPN
afs-72863	486	12	,	,	PUNCT
afs-72863	486	13	steele	steele	PROPN
afs-72863	486	14	,	,	PUNCT
afs-72863	486	15	j.	j.	PROPN
afs-72863	486	16	l.	l.	PROPN
afs-72863	486	17	&	&	CCONJ
afs-72863	486	18	palva	palva	PROPN
afs-72863	486	19	,	,	PUNCT
afs-72863	486	20	a.	a.	NOUN
afs-72863	486	21	1996	1996	NUM
afs-72863	486	22	.	.	PUNCT
afs-72863	487	1	molecular	molecular	ADJ
afs-72863	487	2	characterization	characterization	NOUN
afs-72863	487	3	,	,	PUNCT
afs-72863	487	4	overexpression	overexpression	NOUN
afs-72863	487	5	and	and	CCONJ
afs-72863	487	6	purification	purification	NOUN
afs-72863	487	7	of	of	ADP
afs-72863	487	8	a	a	DET
afs-72863	487	9	novel	novel	NOUN
afs-72863	487	10	dipeptidase	dipeptidase	NOUN
afs-72863	487	11	from	from	ADP
afs-72863	487	12	lactobacillus	lactobacillus	NOUN
afs-72863	487	13	hetveticus	hetveticus	NOUN
afs-72863	487	14	.	.	PUNCT
afs-72863	488	1	applied	apply	VERB
afs-72863	488	2	microbiology	microbiology	NOUN
afs-72863	488	3	and	and	CCONJ
afs-72863	488	4	biotechnology	biotechnology	NOUN
afs-72863	488	5	45	45	NUM
afs-72863	488	6	:	:	PUNCT
afs-72863	488	7	638	638	NUM
afs-72863	488	8	-	-	SYM
afs-72863	488	9	645	645	NUM
afs-72863	488	10	.	.	PUNCT
afs-72863	488	11	,	,	PUNCT
afs-72863	488	12	savijoki	savijoki	PROPN
afs-72863	488	13	,	,	PUNCT
afs-72863	488	14	k.	k.	PROPN
afs-72863	488	15	,	,	PUNCT
afs-72863	488	16	rantanen	rantanen	NOUN
afs-72863	488	17	,	,	PUNCT
afs-72863	488	18	t.	t.	PROPN
afs-72863	488	19	,	,	PUNCT
afs-72863	488	20	steele	steele	PROPN
afs-72863	488	21	,	,	PUNCT
afs-72863	488	22	j.l	j.l	PROPN
afs-72863	488	23	.	.	PROPN
afs-72863	488	24	&	&	CCONJ
afs-72863	488	25	palva	palva	PROPN
afs-72863	488	26	,	,	PUNCT
afs-72863	488	27	a.	a.	NOUN
afs-72863	488	28	1995	1995	NUM
afs-72863	488	29	.	.	PUNCT
afs-72863	489	1	an	an	DET
afs-72863	489	2	x	x	X
afs-72863	489	3	-	-	ADJ
afs-72863	489	4	prolyl	prolyl	ADJ
afs-72863	489	5	dipeptidyl	dipeptidyl	NOUN
afs-72863	489	6	aminopeptidase	aminopeptidase	NOUN
afs-72863	489	7	(	(	PUNCT
afs-72863	489	8	pepx	pepx	NOUN
afs-72863	489	9	)	)	PUNCT
afs-72863	489	10	gene	gene	NOUN
afs-72863	489	11	from	from	ADP
afs-72863	489	12	lactobacillus	lactobacillus	NOUN
afs-72863	489	13	hetveticus	hetveticus	NOUN
afs-72863	489	14	.	.	PUNCT
afs-72863	490	1	microbiology	microbiology	NOUN
afs-72863	490	2	141	141	NUM
afs-72863	490	3	:	:	PUNCT
afs-72863	490	4	3067	3067	NUM
afs-72863	490	5	-	-	SYM
afs-72863	490	6	3075	3075	NUM
afs-72863	490	7	.	.	PUNCT
afs-72863	491	1	,	,	PUNCT
afs-72863	491	2	varmanen	varmanen	PROPN
afs-72863	491	3	,	,	PUNCT
afs-72863	491	4	p.	p.	PROPN
afs-72863	491	5	,	,	PUNCT
afs-72863	491	6	steele	steele	PROPN
afs-72863	491	7	,	,	PUNCT
afs-72863	491	8	j.l	j.l	PROPN
afs-72863	491	9	.	.	PROPN
afs-72863	491	10	&	&	CCONJ
afs-72863	491	11	palva	palva	PROPN
afs-72863	491	12	,	,	PUNCT
afs-72863	491	13	a.	a.	NOUN
afs-72863	491	14	1994	1994	NUM
afs-72863	491	15	.	.	PUNCT
afs-72863	492	1	characterization	characterization	NOUN
afs-72863	492	2	and	and	CCONJ
afs-72863	492	3	expression	expression	NOUN
afs-72863	492	4	of	of	ADP
afs-72863	492	5	the	the	DET
afs-72863	492	6	lactobacillus	lactobacillus	NOUN
afs-72863	492	7	hetveticus	hetveticus	NOUN
afs-72863	492	8	pepcgene	pepcgene	NOUN
afs-72863	492	9	encoding	encode	VERB
afs-72863	492	10	a	a	DET
afs-72863	492	11	general	general	ADJ
afs-72863	492	12	aminopeptidase	aminopeptidase	NOUN
afs-72863	492	13	.	.	PUNCT
afs-72863	493	1	european	european	PROPN
afs-72863	493	2	journal	journal	PROPN
afs-72863	493	3	of	of	ADP
afs-72863	493	4	biochemistry	biochemistry	NOUN
afs-72863	493	5	224	224	NUM
afs-72863	493	6	:	:	PUNCT
afs-72863	493	7	991	991	NUM
afs-72863	493	8	-	-	SYM
afs-72863	493	9	997	997	NUM
afs-72863	493	10	.	.	PUNCT
afs-72863	494	1	vidgrén	vidgrén	VERB
afs-72863	494	2	,	,	PUNCT
afs-72863	494	3	g.	g.	PROPN
afs-72863	494	4	,	,	PUNCT
afs-72863	494	5	palva	palva	NOUN
afs-72863	494	6	,	,	PUNCT
afs-72863	494	7	1	1	NUM
afs-72863	494	8	.	.	NUM
afs-72863	494	9	,	,	PUNCT
afs-72863	494	10	pakkanen	pakkanen	PROPN
afs-72863	494	11	,	,	PUNCT
afs-72863	494	12	r.	r.	PROPN
afs-72863	494	13	,	,	PUNCT
afs-72863	494	14	lounatmaa	lounatmaa	NOUN
afs-72863	494	15	,	,	PUNCT
afs-72863	494	16	k.	k.	PROPN
afs-72863	494	17	&	&	CCONJ
afs-72863	494	18	palva	palva	PROPN
afs-72863	494	19	,	,	PUNCT
afs-72863	494	20	a.	a.	NOUN
afs-72863	494	21	1992	1992	NUM
afs-72863	494	22	,	,	PUNCT
afs-72863	494	23	s	s	NOUN
afs-72863	494	24	-	-	PUNCT
afs-72863	494	25	layer	layer	NOUN
afs-72863	494	26	protein	protein	NOUN
afs-72863	494	27	gene	gene	NOUN
afs-72863	494	28	of	of	ADP
afs-72863	494	29	lactobacillus	lactobacillus	NOUN
afs-72863	494	30	brevis	brevis	NOUN
afs-72863	494	31	:	:	PUNCT
afs-72863	494	32	cloning	cloning	NOUN
afs-72863	494	33	by	by	ADP
afs-72863	494	34	polymerase	polymerase	NOUN
afs-72863	494	35	chain	chain	NOUN
afs-72863	494	36	reaction	reaction	NOUN
afs-72863	494	37	and	and	CCONJ
afs-72863	494	38	determination	determination	NOUN
afs-72863	494	39	of	of	ADP
afs-72863	494	40	the	the	DET
afs-72863	494	41	nucleotide	nucleotide	ADJ
afs-72863	494	42	sequence	sequence	NOUN
afs-72863	494	43	.	.	PUNCT
afs-72863	495	1	journal	journal	PROPN
afs-72863	495	2	of	of	ADP
afs-72863	495	3	bacteriology	bacteriology	NOUN
afs-72863	495	4	174	174	NUM
afs-72863	495	5	:	:	PUNCT
afs-72863	495	6	7419	7419	NUM
afs-72863	495	7	-	-	SYM
afs-72863	495	8	7427	7427	NUM
afs-72863	495	9	.	.	PUNCT
afs-72863	496	1	von	von	PROPN
afs-72863	496	2	heijne	heijne	PROPN
afs-72863	496	3	,	,	PUNCT
afs-72863	496	4	g.	g.	PROPN
afs-72863	496	5	1987	1987	NUM
afs-72863	496	6	.	.	PUNCT
afs-72863	497	1	sequence	sequence	NOUN
afs-72863	497	2	analysis	analysis	NOUN
afs-72863	497	3	in	in	ADP
afs-72863	497	4	molecular	molecular	ADJ
afs-72863	497	5	biology	biology	NOUN
afs-72863	497	6	.	.	PUNCT
afs-72863	498	1	london	london	PROPN
afs-72863	498	2	:	:	PUNCT
afs-72863	498	3	academic	academic	ADJ
afs-72863	498	4	press	press	NOUN
afs-72863	498	5	.	.	PUNCT
afs-72863	499	1	188	188	NUM
afs-72863	499	2	p.	p.	NOUN
afs-72863	499	3	wells	well	NOUN
afs-72863	499	4	,	,	PUNCT
afs-72863	499	5	j.m	j.m	PROPN
afs-72863	499	6	.	.	PROPN
afs-72863	499	7	,	,	PUNCT
afs-72863	499	8	robinson	robinson	PROPN
afs-72863	499	9	,	,	PUNCT
afs-72863	499	10	l.m	l.m	PROPN
afs-72863	499	11	.	.	PROPN
afs-72863	499	12	,	,	PUNCT
afs-72863	499	13	chamberlain	chamberlain	PROPN
afs-72863	499	14	,	,	PUNCT
afs-72863	499	15	l.m	l.m	PROPN
afs-72863	499	16	.	.	PROPN
afs-72863	499	17	,	,	PUNCT
afs-72863	499	18	schonfield	schonfield	PROPN
afs-72863	499	19	,	,	PUNCT
afs-72863	499	20	k.m	k.m	PROPN
afs-72863	499	21	.	.	PROPN
afs-72863	499	22	&	&	CCONJ
afs-72863	499	23	le	le	PROPN
afs-72863	499	24	page	page	PROPN
afs-72863	499	25	,	,	PUNCT
afs-72863	499	26	r.w.f	r.w.f	ADJ
afs-72863	499	27	.	.	PROPN
afs-72863	499	28	1996	1996	NUM
afs-72863	499	29	lactic	lactic	ADJ
afs-72863	499	30	acid	acid	NOUN
afs-72863	499	31	bacteria	bacteria	NOUN
afs-72863	499	32	as	as	ADP
afs-72863	499	33	vaccine	vaccine	NOUN
afs-72863	499	34	delivery	delivery	NOUN
afs-72863	499	35	vehicles	vehicle	NOUN
afs-72863	499	36	.	.	PUNCT
afs-72863	500	1	antonie	antonie	PROPN
afs-72863	500	2	van	van	PROPN
afs-72863	500	3	leeuwenhoek	leeuwenhoek	PROPN
afs-72863	500	4	70	70	NUM
afs-72863	500	5	:	:	PUNCT
afs-72863	500	6	317	317	NUM
afs-72863	500	7	-	-	SYM
afs-72863	500	8	330	330	NUM
afs-72863	500	9	.	.	PUNCT
afs-72863	501	1	wood	wood	NOUN
afs-72863	501	2	,	,	PUNCT
afs-72863	501	3	b.j	b.j	PROPN
afs-72863	501	4	.	.	PUNCT
afs-72863	501	5	(	(	PUNCT
afs-72863	501	6	ed	ed	NOUN
afs-72863	501	7	.	.	PUNCT
afs-72863	501	8	)	)	PUNCT
afs-72863	501	9	.	.	PUNCT
afs-72863	502	1	1992	1992	NUM
afs-72863	502	2	.	.	PUNCT
afs-72863	503	1	the	the	DET
afs-72863	503	2	lactic	lactic	ADJ
afs-72863	503	3	acidbacteria	acidbacteria	NOUN
afs-72863	503	4	in	in	ADP
afs-72863	503	5	health	health	NOUN
afs-72863	503	6	and	and	CCONJ
afs-72863	503	7	disease	disease	NOUN
afs-72863	503	8	.	.	PUNCT
afs-72863	504	1	volume	volume	NOUN
afs-72863	504	2	1	1	NUM
afs-72863	504	3	.	.	PUNCT
afs-72863	504	4	london	london	PROPN
afs-72863	504	5	:	:	PUNCT
afs-72863	504	6	elsevier	elsevier	PROPN
afs-72863	504	7	applied	apply	VERB
afs-72863	504	8	science	science	NOUN
afs-72863	504	9	.	.	PUNCT
afs-72863	505	1	485	485	NUM
afs-72863	505	2	p.	p.	NOUN
afs-72863	505	3	wood	wood	NOUN
afs-72863	505	4	,	,	PUNCT
afs-72863	505	5	8.j.8	8.j.8	NOUN
afs-72863	505	6	.	.	PUNCT
afs-72863	505	7	&	&	CCONJ
afs-72863	505	8	holzapfel	holzapfel	PROPN
afs-72863	505	9	,	,	PUNCT
afs-72863	505	10	w.h	w.h	PROPN
afs-72863	505	11	.	.	PROPN
afs-72863	505	12	(	(	PUNCT
afs-72863	505	13	eds	ed	NOUN
afs-72863	505	14	.	.	PUNCT
afs-72863	505	15	)	)	PUNCT
afs-72863	505	16	.	.	PUNCT
afs-72863	506	1	1995	1995	NUM
afs-72863	506	2	.	.	PUNCT
afs-72863	507	1	the	the	DET
afs-72863	507	2	genera	genera	NOUN
afs-72863	507	3	of	of	ADP
afs-72863	507	4	tactic	tactic	ADJ
afs-72863	507	5	acid	acid	NOUN
afs-72863	507	6	bacteria	bacteria	NOUN
afs-72863	507	7	.	.	PUNCT
afs-72863	508	1	volume	volume	NOUN
afs-72863	508	2	2	2	NUM
afs-72863	508	3	.	.	PUNCT
afs-72863	509	1	london	london	PROPN
afs-72863	509	2	:	:	PUNCT
afs-72863	509	3	blackie	blackie	NOUN
afs-72863	509	4	academic	academic	PROPN
afs-72863	509	5	&	&	CCONJ
afs-72863	509	6	professional	professional	PROPN
afs-72863	509	7	.	.	PUNCT
afs-72863	510	1	398	398	NUM
afs-72863	510	2	p.	p.	NOUN
afs-72863	510	3	281	281	NUM
afs-72863	510	4	vol	vol	NOUN
afs-72863	510	5	.	.	PUNCT
afs-72863	510	6	7	7	NUM
afs-72863	510	7	(	(	PUNCT
afs-72863	510	8	1998	1998	NUM
afs-72863	510	9	):	):	PUNCT
afs-72863	510	10	267	267	NUM
afs-72863	510	11	-	-	SYM
afs-72863	510	12	282	282	NUM
afs-72863	510	13	.	.	PUNCT
afs-72863	510	14	agricultural	agricultural	ADJ
afs-72863	510	15	and	and	CCONJ
afs-72863	510	16	food	food	NOUN
afs-72863	510	17	science	science	NOUN
afs-72863	510	18	in	in	ADP
afs-72863	510	19	finland	finland	PROPN
afs-72863	510	20	selostus	selostus	PROPN
afs-72863	510	21	terveysvaikutteisten	terveysvaikutteisten	VERB
afs-72863	510	22	elintarvikkeiden	elintarvikkeiden	NOUN
afs-72863	510	23	tuottamista	tuottamista	PROPN
afs-72863	510	24	edesauttavat	edesauttavat	PROPN
afs-72863	510	25	maitohappobakteerien	maitohappobakteerien	PROPN
afs-72863	510	26	molekyyligeneettiset	molekyyligeneettiset	VERB
afs-72863	510	27	tutkimukset	tutkimukset	PROPN
afs-72863	510	28	airi	airi	PROPN
afs-72863	510	29	palva	palva	PROPN
afs-72863	510	30	maatalouden	maatalouden	PROPN
afs-72863	510	31	tutkimuskeskus	tutkimuskesku	NOUN
afs-72863	510	32	maitohappobakteereita	maitohappobakteereita	NOUN
afs-72863	510	33	(	(	PUNCT
afs-72863	510	34	mhb	mhb	PROPN
afs-72863	510	35	)	)	PUNCT
afs-72863	510	36	käytetään	käytetään	PROPN
afs-72863	510	37	laajamittaisesti	laajamittaisesti	PROPN
afs-72863	510	38	erilaisten	erilaisten	VERB
afs-72863	510	39	hapatettujen	hapatettujen	NOUN
afs-72863	510	40	maito-	maito-	NOUN
afs-72863	510	41	,	,	PUNCT
afs-72863	510	42	liha-	liha-	ADJ
afs-72863	510	43	,	,	PUNCT
afs-72863	510	44	vihannesja	vihannesja	NOUN
afs-72863	510	45	leipomotuotteiden	leipomotuotteiden	ADJ
afs-72863	510	46	valmistuksessa	valmistuksessa	ADV
afs-72863	510	47	elintarviketeollisuudessa	elintarviketeollisuudessa	ADJ
afs-72863	510	48	,	,	PUNCT
afs-72863	510	49	panimoja	panimoja	PROPN
afs-72863	510	50	viiniteollisuudessa	viiniteollisuudessa	PROPN
afs-72863	510	51	sekä	sekä	PROPN
afs-72863	510	52	säilörehun	säilörehun	PROPN
afs-72863	510	53	valmistuksessa	valmistuksessa	PROPN
afs-72863	510	54	.	.	PUNCT
afs-72863	511	1	eräät	eräät	PROPN
afs-72863	511	2	mhb	mhb	PROPN
afs-72863	511	3	-	-	PUNCT
afs-72863	511	4	kannat	kannat	PROPN
afs-72863	511	5	ovat	ovat	NOUN
afs-72863	511	6	nousemassa	nousemassa	PROPN
afs-72863	512	1	yhä	yhä	PROPN
afs-72863	512	2	tärkeämpään	tärkeämpään	PROPN
afs-72863	512	3	asemaan	asemaan	PROPN
afs-72863	512	4	myös	myös	PROPN
afs-72863	512	5	terveysvaikutteisina	terveysvaikutteisina	PROPN
afs-72863	512	6	probiootteina	probiootteina	PROPN
afs-72863	512	7	.	.	PUNCT
afs-72863	513	1	mhb	mhb	PROPN
afs-72863	513	2	:	:	PUNCT
afs-72863	513	3	n	n	NUM
afs-72863	513	4	molekyyligeneettisen	molekyyligeneettisen	NOUN
afs-72863	513	5	tutkimuksen	tutkimuksen	VERB
afs-72863	513	6	avulla	avulla	PROPN
afs-72863	514	1	pyritään	pyritään	PROPN
afs-72863	514	2	luonnehtimaan	luonnehtimaan	PROPN
afs-72863	514	3	keskeisistä	keskeisistä	PROPN
afs-72863	514	4	hapatekannoista	hapatekannoista	PROPN
afs-72863	514	5	niiden	niiden	PROPN
afs-72863	514	6	fermentaatioprosessin	fermentaatioprosessin	PROPN
afs-72863	514	7	ja	ja	PROPN
afs-72863	514	8	siten	siten	VERB
afs-72863	514	9	lopputuotteen	lopputuotteen	VERB
afs-72863	514	10	onnistumisen	onnistumisen	VERB
afs-72863	514	11	kannalta	kannalta	NOUN
afs-72863	514	12	oleellisten	oleellisten	VERB
afs-72863	514	13	ominaisuuksien	ominaisuuksien	PROPN
afs-72863	514	14	geenitaustaa	geenitaustaa	PROPN
afs-72863	514	15	.	.	PUNCT
afs-72863	515	1	näin	näin	PROPN
afs-72863	515	2	saatava	saatava	PROPN
afs-72863	515	3	tieto	tieto	PROPN
afs-72863	515	4	mahdollistaa	mahdollistaa	PROPN
afs-72863	515	5	mm	mm	PROPN
afs-72863	515	6	.	.	PUNCT
afs-72863	516	1	mhb	mhb	PROPN
afs-72863	516	2	:	:	PUNCT
afs-72863	516	3	n	n	PRON
afs-72863	516	4	oleellisten	oleellisten	VERB
afs-72863	516	5	prosessiominaisuuksien	prosessiominaisuuksien	PROPN
afs-72863	516	6	stabiloinnin	stabiloinnin	PROPN
afs-72863	516	7	ja	ja	PROPN
afs-72863	516	8	parantamisen	parantamisen	PROPN
afs-72863	516	9	geneettisen	geneettisen	VERB
afs-72863	516	10	muokkauksen	muokkauksen	ADJ
afs-72863	516	11	avulla	avulla	NOUN
afs-72863	516	12	.	.	PUNCT
afs-72863	517	1	tämän	tämän	PROPN
afs-72863	517	2	katsauksen	katsauksen	PROPN
afs-72863	517	3	tarkoituksena	tarkoituksena	PROPN
afs-72863	517	4	on	on	ADP
afs-72863	517	5	esitellä	esitellä	NOUN
afs-72863	517	6	kirjoittajan	kirjoittajan	PROPN
afs-72863	517	7	oman	oman	PROPN
afs-72863	517	8	,	,	PUNCT
afs-72863	517	9	mhb	mhb	PROPN
afs-72863	517	10	:	:	PUNCT
afs-72863	517	11	n	n	PRON
afs-72863	517	12	molekyyligenetiikkaan	molekyyligenetiikkaan	PROPN
afs-72863	517	13	keskittyvän	keskittyvän	PROPN
afs-72863	517	14	tutkimusryhmän	tutkimusryhmän	PROPN
afs-72863	517	15	kahden	kahden	PROPN
afs-72863	517	16	keskeisen	keskeisen	PROPN
afs-72863	517	17	projektin	projektin	PROPN
afs-72863	517	18	tavoitteita	tavoitteita	PROPN
afs-72863	517	19	,	,	PUNCT
afs-72863	517	20	tuloksia	tuloksia	PROPN
afs-72863	518	1	ja	ja	PROPN
afs-72863	518	2	soveltamismahdollisuuksia	soveltamismahdollisuuksia	PROPN
afs-72863	518	3	mm	mm	PROPN
afs-72863	518	4	.	.	PROPN
afs-72863	518	5	terveysvaikutteisten	terveysvaikutteisten	PROPN
afs-72863	518	6	elintarvikkeiden	elintarvikkeiden	NOUN
afs-72863	518	7	tuottamisessa	tuottamisessa	PROPN
afs-72863	518	8	.	.	PUNCT
afs-72863	519	1	käsiteltävät	käsiteltävät	PROPN
afs-72863	519	2	alueet	alueet	PROPN
afs-72863	519	3	ovat	ovat	X
afs-72863	519	4	termofiilisten	termofiilisten	VERB
afs-72863	519	5	lactobacillus	lactobacillus	NOUN
afs-72863	519	6	-	-	PUNCT
afs-72863	519	7	sukuun	sukuun	NOUN
afs-72863	519	8	kuuluvien	kuuluvien	NOUN
afs-72863	519	9	teollisten	teollisten	VERB
afs-72863	519	10	hapatekantojen	hapatekantojen	NOUN
afs-72863	519	11	proteolyyttisen	proteolyyttisen	ADJ
afs-72863	519	12	järjestelmän	järjestelmän	PROPN
afs-72863	519	13	molekyyligeneettinen	molekyyligeneettinen	PROPN
afs-72863	519	14	ja	ja	PROPN
afs-72863	519	15	biokemiallinen	biokemiallinen	PROPN
afs-72863	519	16	karakterisointi	karakterisointi	PROPN
afs-72863	519	17	sekä	sekä	PROPN
afs-72863	519	18	lactobacilluspintaproteiinitutkimus	lactobacilluspintaproteiinitutkimus	PROPN
afs-72863	519	19	,	,	PUNCT
afs-72863	519	20	jonka	jonka	PROPN
afs-72863	519	21	avulla	avulla	PROPN
afs-72863	519	22	kehitetään	kehitetään	PROPN
afs-72863	519	23	elintarvike-	elintarvike-	NOUN
afs-72863	519	24	,	,	PUNCT
afs-72863	519	25	rehu-	rehu-	NOUN
afs-72863	519	26	,	,	PUNCT
afs-72863	519	27	rokoteja	rokoteja	PROPN
afs-72863	519	28	diagnostiikkakäyttöön	diagnostiikkakäyttöön	PROPN
afs-72863	519	29	soveltuvia	soveltuvia	VERB
afs-72863	519	30	proteiinituottojärjestelmiä	proteiinituottojärjestelmiä	NOUN
afs-72863	519	31	.	.	PUNCT
afs-72863	520	1	282	282	NUM
afs-72863	520	2	seminar	seminar	NOUN
afs-72863	520	3	in	in	ADP
afs-72863	520	4	honour	honour	NOUN
afs-72863	520	5	of	of	ADP
afs-72863	520	6	the	the	DET
afs-72863	520	7	100th	100th	ADJ
afs-72863	520	8	anniversary	anniversary	NOUN
afs-72863	520	9	ofmtt	ofmtt	NOUN
afs-72863	520	10	agricultural	agricultural	ADJ
afs-72863	520	11	and	and	CCONJ
afs-72863	520	12	food	food	NOUN
afs-72863	520	13	science	science	NOUN
afs-72863	520	14	in	in	ADP
afs-72863	520	15	finland	finland	PROPN