id	sid	tid	token	lemma	pos
aisthesis-3151	1	1	mortality	mortality	NOUN
aisthesis-3151	1	2	rate	rate	NOUN
aisthesis-3151	1	3	is	be	AUX
aisthesis-3151	1	4	calculated	calculate	VERB
aisthesis-3151	1	5	by	by	ADP
aisthesis-3151	1	6	:	:	PUNCT
aisthesis-3151	1	7	mortality	mortality	NOUN
aisthesis-3151	1	8	rate=(estimated	rate=(estimate	VERB
aisthesis-3151	1	9	deaths)/(estimated	deaths)/(estimated	ADJ
aisthesis-3151	1	10	new	new	ADJ
aisthesis-3151	1	11	cases	case	NOUN
aisthesis-3151	1	12	)	)	PUNCT
aisthesis-3151	1	13	figure	figure	NOUN
aisthesis-3151	1	14	1	1	NUM
aisthesis-3151	1	15	:	:	PUNCT
aisthesis-3151	1	16	mortality	mortality	NOUN
aisthesis-3151	1	17	rates	rate	NOUN
aisthesis-3151	1	18	among	among	ADP
aisthesis-3151	1	19	common	common	ADJ
aisthesis-3151	1	20	genitourinary	genitourinary	ADJ
aisthesis-3151	1	21	malignancies	malignancy	NOUN
aisthesis-3151	1	22	.	.	PUNCT
aisthesis-3151	2	1	renal	renal	ADJ
aisthesis-3151	2	2	cell	cell	NOUN
aisthesis-3151	2	3	carcinoma	carcinoma	NOUN
aisthesis-3151	2	4	has	have	VERB
aisthesis-3151	2	5	the	the	DET
aisthesis-3151	2	6	greatest	great	ADJ
aisthesis-3151	2	7	mortality	mortality	NOUN
aisthesis-3151	2	8	rate	rate	NOUN
aisthesis-3151	2	9	(	(	PUNCT
aisthesis-3151	2	10	nearly	nearly	ADV
aisthesis-3151	2	11	23	23	NUM
aisthesis-3151	2	12	%	%	NOUN
aisthesis-3151	2	13	)	)	PUNCT
aisthesis-3151	2	14	among	among	ADP
aisthesis-3151	2	15	the	the	DET
aisthesis-3151	2	16	common	common	ADJ
aisthesis-3151	2	17	genitourinary	genitourinary	ADJ
aisthesis-3151	2	18	cancers	cancer	NOUN
aisthesis-3151	2	19	,	,	PUNCT
aisthesis-3151	2	20	followed	follow	VERB
aisthesis-3151	2	21	by	by	ADP
aisthesis-3151	2	22	bladder	bladder	NOUN
aisthesis-3151	2	23	cancer	cancer	NOUN
aisthesis-3151	2	24	(	(	PUNCT
aisthesis-3151	2	25	approximately	approximately	ADV
aisthesis-3151	2	26	21	21	NUM
aisthesis-3151	2	27	%	%	NOUN
aisthesis-3151	2	28	)	)	PUNCT
aisthesis-3151	2	29	,	,	PUNCT
aisthesis-3151	2	30	endometrial	endometrial	ADJ
aisthesis-3151	2	31	cancer	cancer	NOUN
aisthesis-3151	2	32	(	(	PUNCT
aisthesis-3151	2	33	approximately	approximately	ADV
aisthesis-3151	2	34	18	18	NUM
aisthesis-3151	2	35	%	%	NOUN
aisthesis-3151	2	36	)	)	PUNCT
aisthesis-3151	2	37	,	,	PUNCT
aisthesis-3151	2	38	and	and	CCONJ
aisthesis-3151	2	39	prostate	prostate	NOUN
aisthesis-3151	2	40	cancer	cancer	NOUN
aisthesis-3151	2	41	(	(	PUNCT
aisthesis-3151	2	42	nearly	nearly	ADV
aisthesis-3151	2	43	18	18	NUM
aisthesis-3151	2	44	%	%	NOUN
aisthesis-3151	2	45	)	)	PUNCT
aisthesis-3151	2	46	.	.	PUNCT
aisthesis-3151	3	1	figure	figure	NOUN
aisthesis-3151	3	2	is	be	AUX
aisthesis-3151	3	3	based	base	VERB
aisthesis-3151	3	4	on	on	ADP
aisthesis-3151	3	5	“	"	PUNCT
aisthesis-3151	3	6	cancer	cancer	NOUN
aisthesis-3151	3	7	facts	fact	NOUN
aisthesis-3151	3	8	&	&	CCONJ
aisthesis-3151	3	9	figures	figure	NOUN
aisthesis-3151	3	10	2018	2018	NUM
aisthesis-3151	3	11	”	"	PUNCT
aisthesis-3151	3	12	(	(	PUNCT
aisthesis-3151	3	13	american	american	ADJ
aisthesis-3151	3	14	cancer	cancer	NOUN
aisthesis-3151	3	15	society	society	NOUN
aisthesis-3151	3	16	,	,	PUNCT
aisthesis-3151	3	17	2018	2018	NUM
aisthesis-3151	3	18	)	)	PUNCT
aisthesis-3151	3	19	.	.	PUNCT
aisthesis-3151	4	1	abstract	abstract	ADJ
aisthesis-3151	4	2	:	:	PUNCT
aisthesis-3151	4	3	renal	renal	ADJ
aisthesis-3151	4	4	cell	cell	NOUN
aisthesis-3151	4	5	carcinoma	carcinoma	NOUN
aisthesis-3151	4	6	is	be	AUX
aisthesis-3151	4	7	a	a	DET
aisthesis-3151	4	8	malignancy	malignancy	NOUN
aisthesis-3151	4	9	of	of	ADP
aisthesis-3151	4	10	the	the	DET
aisthesis-3151	4	11	kidney	kidney	NOUN
aisthesis-3151	4	12	,	,	PUNCT
aisthesis-3151	4	13	and	and	CCONJ
aisthesis-3151	4	14	is	be	AUX
aisthesis-3151	4	15	among	among	ADP
aisthesis-3151	4	16	the	the	DET
aisthesis-3151	4	17	most	most	ADV
aisthesis-3151	4	18	common	common	ADJ
aisthesis-3151	4	19	and	and	CCONJ
aisthesis-3151	4	20	lethal	lethal	ADJ
aisthesis-3151	4	21	cancers	cancer	NOUN
aisthesis-3151	4	22	a!ecting	a!ecte	VERB
aisthesis-3151	4	23	the	the	DET
aisthesis-3151	4	24	genitourinary	genitourinary	ADJ
aisthesis-3151	4	25	tract	tract	NOUN
aisthesis-3151	4	26	in	in	ADP
aisthesis-3151	4	27	males	male	NOUN
aisthesis-3151	4	28	and	and	CCONJ
aisthesis-3151	4	29	females	female	NOUN
aisthesis-3151	4	30	.	.	PUNCT
aisthesis-3151	5	1	as	as	SCONJ
aisthesis-3151	5	2	the	the	DET
aisthesis-3151	5	3	kidneys	kidney	NOUN
aisthesis-3151	5	4	play	play	VERB
aisthesis-3151	5	5	a	a	DET
aisthesis-3151	5	6	critical	critical	ADJ
aisthesis-3151	5	7	role	role	NOUN
aisthesis-3151	5	8	in	in	ADP
aisthesis-3151	5	9	maintaining	maintain	VERB
aisthesis-3151	5	10	homeostasis	homeostasis	NOUN
aisthesis-3151	5	11	in	in	ADP
aisthesis-3151	5	12	an	an	DET
aisthesis-3151	5	13	organism	organism	NOUN
aisthesis-3151	5	14	(	(	PUNCT
aisthesis-3151	5	15	particularly	particularly	ADV
aisthesis-3151	5	16	by	by	ADP
aisthesis-3151	5	17	regulating	regulate	VERB
aisthesis-3151	5	18	excretion	excretion	NOUN
aisthesis-3151	5	19	and	and	CCONJ
aisthesis-3151	5	20	reabsorption	reabsorption	NOUN
aisthesis-3151	5	21	of	of	ADP
aisthesis-3151	5	22	solutes	solute	NOUN
aisthesis-3151	5	23	,	,	PUNCT
aisthesis-3151	5	24	in"uencing	in"uence	VERB
aisthesis-3151	5	25	hormone	hormone	NOUN
aisthesis-3151	5	26	release	release	NOUN
aisthesis-3151	5	27	,	,	PUNCT
aisthesis-3151	5	28	and	and	CCONJ
aisthesis-3151	5	29	maintaining	maintain	VERB
aisthesis-3151	5	30	blood	blood	NOUN
aisthesis-3151	5	31	pressure	pressure	NOUN
aisthesis-3151	5	32	)	)	PUNCT
aisthesis-3151	5	33	,	,	PUNCT
aisthesis-3151	5	34	malignancies	malignancy	NOUN
aisthesis-3151	5	35	of	of	ADP
aisthesis-3151	5	36	these	these	DET
aisthesis-3151	5	37	organs	organ	NOUN
aisthesis-3151	5	38	have	have	VERB
aisthesis-3151	5	39	several	several	ADJ
aisthesis-3151	5	40	complex	complex	ADJ
aisthesis-3151	5	41	side	side	NOUN
aisthesis-3151	5	42	e!ects	e!ect	NOUN
aisthesis-3151	5	43	.	.	PUNCT
aisthesis-3151	6	1	#	#	SYM
aisthesis-3151	6	2	e	e	NOUN
aisthesis-3151	6	3	most	most	ADV
aisthesis-3151	6	4	common	common	ADJ
aisthesis-3151	6	5	genetic	genetic	ADJ
aisthesis-3151	6	6	de$ciency	de$ciency	NOUN
aisthesis-3151	6	7	observed	observe	VERB
aisthesis-3151	6	8	in	in	ADP
aisthesis-3151	6	9	renal	renal	ADJ
aisthesis-3151	6	10	cell	cell	NOUN
aisthesis-3151	6	11	carcinoma	carcinoma	NOUN
aisthesis-3151	6	12	is	be	AUX
aisthesis-3151	6	13	inactivation	inactivation	NOUN
aisthesis-3151	6	14	or	or	CCONJ
aisthesis-3151	6	15	mutation	mutation	NOUN
aisthesis-3151	6	16	of	of	ADP
aisthesis-3151	6	17	the	the	DET
aisthesis-3151	6	18	von	von	PROPN
aisthesis-3151	6	19	hippel	hippel	PROPN
aisthesis-3151	6	20	-	-	PUNCT
aisthesis-3151	6	21	lindau	lindau	NOUN
aisthesis-3151	6	22	(	(	PUNCT
aisthesis-3151	6	23	vhl	vhl	NOUN
aisthesis-3151	6	24	)	)	PUNCT
aisthesis-3151	6	25	tumor	tumor	NOUN
aisthesis-3151	6	26	suppressor	suppressor	NOUN
aisthesis-3151	6	27	gene	gene	NOUN
aisthesis-3151	6	28	,	,	PUNCT
aisthesis-3151	6	29	which	which	PRON
aisthesis-3151	6	30	is	be	AUX
aisthesis-3151	6	31	critical	critical	ADJ
aisthesis-3151	6	32	for	for	ADP
aisthesis-3151	6	33	hypoxia	hypoxia	NOUN
aisthesis-3151	6	34	-	-	PUNCT
aisthesis-3151	6	35	induced	induce	VERB
aisthesis-3151	6	36	angiogenesis	angiogenesis	NOUN
aisthesis-3151	6	37	and	and	CCONJ
aisthesis-3151	6	38	has	have	AUX
aisthesis-3151	6	39	generated	generate	VERB
aisthesis-3151	6	40	several	several	ADJ
aisthesis-3151	6	41	hypotheses	hypothesis	NOUN
aisthesis-3151	6	42	on	on	ADP
aisthesis-3151	6	43	how	how	SCONJ
aisthesis-3151	6	44	to	to	PART
aisthesis-3151	6	45	treat	treat	VERB
aisthesis-3151	6	46	the	the	DET
aisthesis-3151	6	47	malignancy.%a&er	malignancy.%a&er	NOUN
aisthesis-3151	6	48	the	the	DET
aisthesis-3151	6	49	initial	initial	ADJ
aisthesis-3151	6	50	surgery	surgery	NOUN
aisthesis-3151	6	51	or	or	CCONJ
aisthesis-3151	6	52	radiation	radiation	NOUN
aisthesis-3151	6	53	to	to	ADP
aisthesis-3151	6	54	the	the	DET
aisthesis-3151	6	55	localized	localize	VERB
aisthesis-3151	6	56	disease	disease	NOUN
aisthesis-3151	6	57	,	,	PUNCT
aisthesis-3151	6	58	systemic	systemic	ADJ
aisthesis-3151	6	59	pharmacological	pharmacological	ADJ
aisthesis-3151	6	60	agents	agent	NOUN
aisthesis-3151	6	61	are	be	AUX
aisthesis-3151	6	62	utilized	utilize	VERB
aisthesis-3151	6	63	to	to	PART
aisthesis-3151	6	64	prolong	prolong	VERB
aisthesis-3151	6	65	survival	survival	NOUN
aisthesis-3151	6	66	once	once	SCONJ
aisthesis-3151	6	67	the	the	DET
aisthesis-3151	6	68	cancer	cancer	NOUN
aisthesis-3151	6	69	has	have	AUX
aisthesis-3151	6	70	metastasized	metastasize	VERB
aisthesis-3151	6	71	.	.	PUNCT
aisthesis-3151	7	1	#	#	SYM
aisthesis-3151	7	2	e	e	NOUN
aisthesis-3151	7	3	aim	aim	NOUN
aisthesis-3151	7	4	of	of	ADP
aisthesis-3151	7	5	this	this	DET
aisthesis-3151	7	6	review	review	NOUN
aisthesis-3151	7	7	is	be	AUX
aisthesis-3151	7	8	to	to	PART
aisthesis-3151	7	9	present	present	VERB
aisthesis-3151	7	10	the	the	DET
aisthesis-3151	7	11	evolution	evolution	NOUN
aisthesis-3151	7	12	of	of	ADP
aisthesis-3151	7	13	pharmacological	pharmacological	ADJ
aisthesis-3151	7	14	agents	agent	NOUN
aisthesis-3151	7	15	in	in	ADP
aisthesis-3151	7	16	managing	manage	VERB
aisthesis-3151	7	17	renal	renal	ADJ
aisthesis-3151	7	18	cell	cell	NOUN
aisthesis-3151	7	19	carcinoma	carcinoma	NOUN
aisthesis-3151	7	20	.	.	PUNCT
aisthesis-3151	8	1	in	in	ADP
aisthesis-3151	8	2	its	its	PRON
aisthesis-3151	8	3	three	three	NUM
aisthesis-3151	8	4	main	main	ADJ
aisthesis-3151	8	5	sections	section	NOUN
aisthesis-3151	8	6	,	,	PUNCT
aisthesis-3151	8	7	this	this	DET
aisthesis-3151	8	8	review	review	NOUN
aisthesis-3151	8	9	will	will	AUX
aisthesis-3151	8	10	explore	explore	VERB
aisthesis-3151	8	11	cytokine	cytokine	NOUN
aisthesis-3151	8	12	immunotherapies	immunotherapy	NOUN
aisthesis-3151	8	13	utilized	utilize	VERB
aisthesis-3151	8	14	in	in	ADP
aisthesis-3151	8	15	the	the	DET
aisthesis-3151	8	16	1990s	1990	NOUN
aisthesis-3151	8	17	,	,	PUNCT
aisthesis-3151	8	18	vascular	vascular	ADJ
aisthesis-3151	8	19	endothelial	endothelial	ADJ
aisthesis-3151	8	20	growth	growth	NOUN
aisthesis-3151	8	21	factor	factor	NOUN
aisthesis-3151	8	22	-	-	PUNCT
aisthesis-3151	8	23	tyrosine	tyrosine	NOUN
aisthesis-3151	8	24	kinase	kinase	PROPN
aisthesis-3151	8	25	inhibitor	inhibitor	PROPN
aisthesis-3151	8	26	(	(	PUNCT
aisthesis-3151	8	27	vegf	vegf	PROPN
aisthesis-3151	8	28	-	-	PUNCT
aisthesis-3151	8	29	tkis	tkis	PROPN
aisthesis-3151	8	30	)	)	PUNCT
aisthesis-3151	8	31	systemic	systemic	ADJ
aisthesis-3151	8	32	therapies	therapy	NOUN
aisthesis-3151	8	33	devised	devise	VERB
aisthesis-3151	8	34	in	in	ADP
aisthesis-3151	8	35	the	the	DET
aisthesis-3151	8	36	2000s	2000s	NUM
aisthesis-3151	8	37	,	,	PUNCT
aisthesis-3151	8	38	and	and	CCONJ
aisthesis-3151	8	39	$	$	SYM
aisthesis-3151	8	40	nally	nally	ADV
aisthesis-3151	8	41	treatment	treatment	VERB
aisthesis-3151	8	42	with	with	ADP
aisthesis-3151	8	43	targeted	target	VERB
aisthesis-3151	8	44	immunotherapies	immunotherapy	NOUN
aisthesis-3151	8	45	.	.	PUNCT
aisthesis-3151	9	1	with	with	ADP
aisthesis-3151	9	2	the	the	DET
aisthesis-3151	9	3	rapid	rapid	ADJ
aisthesis-3151	9	4	pace	pace	NOUN
aisthesis-3151	9	5	of	of	ADP
aisthesis-3151	9	6	pharmaceutical	pharmaceutical	ADJ
aisthesis-3151	9	7	development	development	NOUN
aisthesis-3151	9	8	,	,	PUNCT
aisthesis-3151	9	9	the	the	DET
aisthesis-3151	9	10	prognosis	prognosis	NOUN
aisthesis-3151	9	11	for	for	ADP
aisthesis-3151	9	12	renal	renal	ADJ
aisthesis-3151	9	13	cell	cell	NOUN
aisthesis-3151	9	14	carcinoma	carcinoma	NOUN
aisthesis-3151	9	15	continues	continue	VERB
aisthesis-3151	9	16	to	to	PART
aisthesis-3151	9	17	improve	improve	VERB
aisthesis-3151	9	18	.	.	PUNCT
aisthesis-3151	10	1	aisthesis	aisthesis	NOUN
aisthesis-3151	10	2	volume	volume	NOUN
aisthesis-3151	10	3	11	11	NUM
aisthesis-3151	10	4	,	,	PUNCT
aisthesis-3151	10	5	20201	20201	NUM
aisthesis-3151	10	6	!	!	PUNCT
aisthesis-3151	11	1	e	e	X
aisthesis-3151	11	2	past	past	NOUN
aisthesis-3151	11	3	,	,	PUNCT
aisthesis-3151	11	4	present	present	ADJ
aisthesis-3151	11	5	,	,	PUNCT
aisthesis-3151	11	6	and	and	CCONJ
aisthesis-3151	11	7	future	future	NOUN
aisthesis-3151	11	8	of	of	ADP
aisthesis-3151	11	9	renal	renal	ADJ
aisthesis-3151	11	10	cell	cell	NOUN
aisthesis-3151	11	11	carcinoma	carcinoma	NOUN
aisthesis-3151	11	12	treatment	treatment	NOUN
aisthesis-3151	11	13	:	:	PUNCT
aisthesis-3151	11	14	a	a	DET
aisthesis-3151	11	15	systematic	systematic	ADJ
aisthesis-3151	11	16	review	review	NOUN
aisthesis-3151	11	17	by	by	ADP
aisthesis-3151	11	18	nityam	nityam	ADJ
aisthesis-3151	11	19	rathi	rathi	PROPN
aisthesis-3151	11	20	introduction	introduction	NOUN
aisthesis-3151	11	21	renal	renal	ADJ
aisthesis-3151	11	22	cell	cell	NOUN
aisthesis-3151	11	23	carcinoma	carcinoma	NOUN
aisthesis-3151	11	24	is	be	AUX
aisthesis-3151	11	25	a	a	DET
aisthesis-3151	11	26	malignancy	malignancy	NOUN
aisthesis-3151	11	27	of	of	ADP
aisthesis-3151	11	28	the	the	DET
aisthesis-3151	11	29	kidney	kidney	NOUN
aisthesis-3151	11	30	and	and	CCONJ
aisthesis-3151	11	31	is	be	AUX
aisthesis-3151	11	32	among	among	ADP
aisthesis-3151	11	33	the	the	DET
aisthesis-3151	11	34	most	most	ADV
aisthesis-3151	11	35	common	common	ADJ
aisthesis-3151	11	36	cancers	cancer	NOUN
aisthesis-3151	11	37	a!ecting	a!ecte	VERB
aisthesis-3151	11	38	the	the	DET
aisthesis-3151	11	39	genitourinary	genitourinary	ADJ
aisthesis-3151	11	40	tract	tract	NOUN
aisthesis-3151	11	41	in	in	ADP
aisthesis-3151	11	42	males	male	NOUN
aisthesis-3151	11	43	and	and	CCONJ
aisthesis-3151	11	44	females	female	NOUN
aisthesis-3151	11	45	.	.	PUNCT
aisthesis-3151	12	1	while	while	SCONJ
aisthesis-3151	12	2	much	much	ADJ
aisthesis-3151	12	3	progress	progress	NOUN
aisthesis-3151	12	4	has	have	AUX
aisthesis-3151	12	5	been	be	AUX
aisthesis-3151	12	6	made	make	VERB
aisthesis-3151	12	7	in	in	ADP
aisthesis-3151	12	8	the	the	DET
aisthesis-3151	12	9	management	management	NOUN
aisthesis-3151	12	10	and	and	CCONJ
aisthesis-3151	12	11	diagnosis	diagnosis	NOUN
aisthesis-3151	12	12	of	of	ADP
aisthesis-3151	12	13	renal	renal	ADJ
aisthesis-3151	12	14	cell	cell	NOUN
aisthesis-3151	12	15	carcinoma	carcinoma	NOUN
aisthesis-3151	12	16	,	,	PUNCT
aisthesis-3151	12	17	it	it	PRON
aisthesis-3151	12	18	remains	remain	VERB
aisthesis-3151	12	19	one	one	NUM
aisthesis-3151	12	20	of	of	ADP
aisthesis-3151	12	21	the	the	DET
aisthesis-3151	12	22	most	most	ADV
aisthesis-3151	12	23	lethal	lethal	ADJ
aisthesis-3151	12	24	cancers	cancer	NOUN
aisthesis-3151	12	25	,	,	PUNCT
aisthesis-3151	12	26	giving	give	VERB
aisthesis-3151	12	27	rise	rise	NOUN
aisthesis-3151	12	28	to	to	ADP
aisthesis-3151	12	29	more	more	ADJ
aisthesis-3151	12	30	than	than	ADP
aisthesis-3151	12	31	140,000	140,000	NUM
aisthesis-3151	12	32	cancer	cancer	NOUN
aisthesis-3151	12	33	-	-	PUNCT
aisthesis-3151	12	34	related	relate	VERB
aisthesis-3151	12	35	deaths	death	NOUN
aisthesis-3151	12	36	yearly	yearly	ADV
aisthesis-3151	12	37	(	(	PUNCT
aisthesis-3151	12	38	capitanio	capitanio	PROPN
aisthesis-3151	12	39	et	et	PROPN
aisthesis-3151	12	40	al	al	PROPN
aisthesis-3151	12	41	.	.	PROPN
aisthesis-3151	12	42	,	,	PUNCT
aisthesis-3151	12	43	2019	2019	NUM
aisthesis-3151	12	44	)	)	PUNCT
aisthesis-3151	12	45	.	.	PUNCT
aisthesis-3151	13	1	among	among	ADP
aisthesis-3151	13	2	the	the	DET
aisthesis-3151	13	3	most	most	ADV
aisthesis-3151	13	4	common	common	ADJ
aisthesis-3151	13	5	genitourinary	genitourinary	ADJ
aisthesis-3151	13	6	malignancies	malignancy	NOUN
aisthesis-3151	13	7	(	(	PUNCT
aisthesis-3151	13	8	including	include	VERB
aisthesis-3151	13	9	renal	renal	ADJ
aisthesis-3151	13	10	cell	cell	NOUN
aisthesis-3151	13	11	,	,	PUNCT
aisthesis-3151	13	12	bladder	bladder	NOUN
aisthesis-3151	13	13	,	,	PUNCT
aisthesis-3151	13	14	prostate	prostate	NOUN
aisthesis-3151	13	15	,	,	PUNCT
aisthesis-3151	13	16	and	and	CCONJ
aisthesis-3151	13	17	endometrial	endometrial	ADJ
aisthesis-3151	13	18	cancers	cancer	NOUN
aisthesis-3151	13	19	)	)	PUNCT
aisthesis-3151	13	20	,	,	PUNCT
aisthesis-3151	13	21	renal	renal	ADJ
aisthesis-3151	13	22	cell	cell	NOUN
aisthesis-3151	13	23	carcinoma	carcinoma	NOUN
aisthesis-3151	13	24	has	have	VERB
aisthesis-3151	13	25	the	the	DET
aisthesis-3151	13	26	greatest	great	ADJ
aisthesis-3151	13	27	mortality	mortality	NOUN
aisthesis-3151	13	28	rate	rate	NOUN
aisthesis-3151	13	29	(	(	PUNCT
aisthesis-3151	13	30	figure	figure	NOUN
aisthesis-3151	13	31	1	1	NUM
aisthesis-3151	13	32	)	)	PUNCT
aisthesis-3151	13	33	(	(	PUNCT
aisthesis-3151	13	34	american	american	ADJ
aisthesis-3151	13	35	cancer	cancer	NOUN
aisthesis-3151	13	36	society	society	NOUN
aisthesis-3151	13	37	,	,	PUNCT
aisthesis-3151	13	38	2018	2018	NUM
aisthesis-3151	13	39	)	)	PUNCT
aisthesis-3151	13	40	.	.	PUNCT
aisthesis-3151	14	1	because	because	SCONJ
aisthesis-3151	14	2	the	the	DET
aisthesis-3151	14	3	kidneys	kidney	NOUN
aisthesis-3151	14	4	play	play	VERB
aisthesis-3151	14	5	a	a	DET
aisthesis-3151	14	6	critical	critical	ADJ
aisthesis-3151	14	7	role	role	NOUN
aisthesis-3151	14	8	in	in	ADP
aisthesis-3151	14	9	maintaining	maintain	VERB
aisthesis-3151	14	10	homeostasis	homeostasis	NOUN
aisthesis-3151	14	11	in	in	ADP
aisthesis-3151	14	12	an	an	DET
aisthesis-3151	14	13	organism	organism	NOUN
aisthesis-3151	14	14	—	—	PUNCT
aisthesis-3151	14	15	particularly	particularly	ADV
aisthesis-3151	14	16	by	by	ADP
aisthesis-3151	14	17	regulating	regulate	VERB
aisthesis-3151	14	18	excretion	excretion	NOUN
aisthesis-3151	14	19	and	and	CCONJ
aisthesis-3151	14	20	reabsorption	reabsorption	NOUN
aisthesis-3151	14	21	of	of	ADP
aisthesis-3151	14	22	solutes	solute	NOUN
aisthesis-3151	14	23	,	,	PUNCT
aisthesis-3151	14	24	in"uencing	in"uence	VERB
aisthesis-3151	14	25	hormone	hormone	NOUN
aisthesis-3151	14	26	release	release	NOUN
aisthesis-3151	14	27	,	,	PUNCT
aisthesis-3151	14	28	and	and	CCONJ
aisthesis-3151	14	29	maintaining	maintain	VERB
aisthesis-3151	14	30	blood	blood	NOUN
aisthesis-3151	14	31	pressure	pressure	NOUN
aisthesis-3151	14	32	—	—	PUNCT
aisthesis-3151	14	33	malignancies	malignancy	NOUN
aisthesis-3151	14	34	of	of	ADP
aisthesis-3151	14	35	these	these	DET
aisthesis-3151	14	36	organs	organ	NOUN
aisthesis-3151	14	37	have	have	VERB
aisthesis-3151	14	38	several	several	ADJ
aisthesis-3151	14	39	complex	complex	ADJ
aisthesis-3151	14	40	side	side	NOUN
aisthesis-3151	14	41	e!ects	e!ect	NOUN
aisthesis-3151	14	42	.	.	PUNCT
aisthesis-3151	15	1	#	#	SYM
aisthesis-3151	15	2	e	e	NOUN
aisthesis-3151	15	3	hallmarks	hallmark	NOUN
aisthesis-3151	15	4	of	of	ADP
aisthesis-3151	15	5	kidney	kidney	NOUN
aisthesis-3151	15	6	cancer	cancer	NOUN
aisthesis-3151	15	7	include	include	VERB
aisthesis-3151	15	8	blood	blood	NOUN
aisthesis-3151	15	9	in	in	ADP
aisthesis-3151	15	10	the	the	DET
aisthesis-3151	15	11	urine	urine	NOUN
aisthesis-3151	15	12	,	,	PUNCT
aisthesis-3151	15	13	chronic	chronic	ADJ
aisthesis-3151	15	14	pain	pain	NOUN
aisthesis-3151	15	15	in	in	ADP
aisthesis-3151	15	16	the	the	DET
aisthesis-3151	15	17	back	back	NOUN
aisthesis-3151	15	18	,	,	PUNCT
aisthesis-3151	15	19	fever	fever	NOUN
aisthesis-3151	15	20	,	,	PUNCT
aisthesis-3151	15	21	fatigue	fatigue	NOUN
aisthesis-3151	15	22	,	,	PUNCT
aisthesis-3151	15	23	and	and	CCONJ
aisthesis-3151	15	24	ultimately	ultimately	ADV
aisthesis-3151	15	25	death	death	NOUN
aisthesis-3151	15	26	from	from	ADP
aisthesis-3151	15	27	metastasis	metastasis	NOUN
aisthesis-3151	15	28	.	.	PUNCT
aisthesis-3151	16	1	common	common	ADJ
aisthesis-3151	16	2	sites	site	NOUN
aisthesis-3151	16	3	of	of	ADP
aisthesis-3151	16	4	metastasis	metastasis	NOUN
aisthesis-3151	16	5	include	include	VERB
aisthesis-3151	16	6	the	the	DET
aisthesis-3151	16	7	lungs	lung	NOUN
aisthesis-3151	16	8	,	,	PUNCT
aisthesis-3151	16	9	bones	bone	NOUN
aisthesis-3151	16	10	,	,	PUNCT
aisthesis-3151	16	11	lymph	lymph	NOUN
aisthesis-3151	16	12	nodes	node	NOUN
aisthesis-3151	16	13	,	,	PUNCT
aisthesis-3151	16	14	liver	liver	NOUN
aisthesis-3151	16	15	,	,	PUNCT
aisthesis-3151	16	16	adrenal	adrenal	ADJ
aisthesis-3151	16	17	glands	gland	NOUN
aisthesis-3151	16	18	,	,	PUNCT
aisthesis-3151	16	19	and	and	CCONJ
aisthesis-3151	16	20	brain	brain	NOUN
aisthesis-3151	16	21	(	(	PUNCT
aisthesis-3151	16	22	bianchi	bianchi	NOUN
aisthesis-3151	16	23	et	et	PROPN
aisthesis-3151	16	24	al	al	PROPN
aisthesis-3151	16	25	.	.	PROPN
aisthesis-3151	16	26	,	,	PUNCT
aisthesis-3151	16	27	2012	2012	NUM
aisthesis-3151	16	28	)	)	PUNCT
aisthesis-3151	16	29	;	;	PUNCT
aisthesis-3151	16	30	as	as	ADP
aisthesis-3151	16	31	such	such	ADJ
aisthesis-3151	16	32	,	,	PUNCT
aisthesis-3151	16	33	treating	treat	VERB
aisthesis-3151	16	34	this	this	DET
aisthesis-3151	16	35	cancer	cancer	NOUN
aisthesis-3151	16	36	early	early	ADV
aisthesis-3151	16	37	on	on	ADV
aisthesis-3151	16	38	may	may	AUX
aisthesis-3151	16	39	prevent	prevent	VERB
aisthesis-3151	16	40	failure	failure	NOUN
aisthesis-3151	16	41	of	of	ADP
aisthesis-3151	16	42	other	other	ADJ
aisthesis-3151	16	43	necessary	necessary	ADJ
aisthesis-3151	16	44	organ	organ	NOUN
aisthesis-3151	16	45	systems	system	NOUN
aisthesis-3151	16	46	.	.	PUNCT
aisthesis-3151	17	1	over	over	ADP
aisthesis-3151	17	2	the	the	DET
aisthesis-3151	17	3	last	last	ADJ
aisthesis-3151	17	4	30	30	NUM
aisthesis-3151	17	5	years	year	NOUN
aisthesis-3151	17	6	,	,	PUNCT
aisthesis-3151	17	7	the	the	DET
aisthesis-3151	17	8	treatment	treatment	NOUN
aisthesis-3151	17	9	landscape	landscape	NOUN
aisthesis-3151	17	10	for	for	ADP
aisthesis-3151	17	11	renal	renal	ADJ
aisthesis-3151	17	12	cell	cell	NOUN
aisthesis-3151	17	13	carcinoma	carcinoma	NOUN
aisthesis-3151	17	14	has	have	AUX
aisthesis-3151	17	15	changed	change	VERB
aisthesis-3151	17	16	drastically	drastically	ADV
aisthesis-3151	17	17	,	,	PUNCT
aisthesis-3151	17	18	as	as	SCONJ
aisthesis-3151	17	19	more	more	ADJ
aisthesis-3151	17	20	has	have	AUX
aisthesis-3151	17	21	been	be	AUX
aisthesis-3151	17	22	learned	learn	VERB
aisthesis-3151	17	23	about	about	ADP
aisthesis-3151	17	24	its	its	PRON
aisthesis-3151	17	25	development	development	NOUN
aisthesis-3151	17	26	and	and	CCONJ
aisthesis-3151	17	27	progression	progression	NOUN
aisthesis-3151	17	28	.	.	PUNCT
aisthesis-3151	18	1	renal	renal	ADJ
aisthesis-3151	18	2	cell	cell	NOUN
aisthesis-3151	18	3	carcinoma	carcinoma	NOUN
aisthesis-3151	18	4	can	can	AUX
aisthesis-3151	18	5	be	be	AUX
aisthesis-3151	18	6	inherited	inherit	VERB
aisthesis-3151	18	7	or	or	CCONJ
aisthesis-3151	18	8	sporadic	sporadic	ADJ
aisthesis-3151	18	9	.	.	PUNCT
aisthesis-3151	19	1	patients	patient	NOUN
aisthesis-3151	19	2	who	who	PRON
aisthesis-3151	19	3	inherit	inherit	VERB
aisthesis-3151	19	4	mutations	mutation	NOUN
aisthesis-3151	19	5	that	that	PRON
aisthesis-3151	19	6	give	give	VERB
aisthesis-3151	19	7	rise	rise	NOUN
aisthesis-3151	19	8	to	to	ADP
aisthesis-3151	19	9	renal	renal	ADJ
aisthesis-3151	19	10	cell	cell	NOUN
aisthesis-3151	19	11	carcinoma	carcinoma	NOUN
aisthesis-3151	19	12	typically	typically	ADV
aisthesis-3151	19	13	begin	begin	VERB
aisthesis-3151	19	14	demonstrating	demonstrate	VERB
aisthesis-3151	19	15	!	!	PUNCT
aisthesis-3151	20	1	e	e	X
aisthesis-3151	20	2	past	past	NOUN
aisthesis-3151	20	3	,	,	PUNCT
aisthesis-3151	20	4	present	present	ADJ
aisthesis-3151	20	5	,	,	PUNCT
aisthesis-3151	20	6	and	and	CCONJ
aisthesis-3151	20	7	future	future	NOUN
aisthesis-3151	20	8	of	of	ADP
aisthesis-3151	20	9	renal	renal	ADJ
aisthesis-3151	20	10	cell	cell	NOUN
aisthesis-3151	20	11	carcinoma	carcinoma	NOUN
aisthesis-3151	20	12	treatment	treatment	NOUN
aisthesis-3151	20	13	aisthesis	aisthesis	NOUN
aisthesis-3151	20	14	volume	volume	NOUN
aisthesis-3151	20	15	11	11	NUM
aisthesis-3151	20	16	,	,	PUNCT
aisthesis-3151	20	17	20202	20202	NUM
aisthesis-3151	20	18	numerous	numerous	ADJ
aisthesis-3151	20	19	cancerous	cancerous	ADJ
aisthesis-3151	20	20	nodules	nodule	NOUN
aisthesis-3151	20	21	in	in	ADP
aisthesis-3151	20	22	the	the	DET
aisthesis-3151	20	23	kidney	kidney	NOUN
aisthesis-3151	20	24	at	at	ADP
aisthesis-3151	20	25	around	around	ADP
aisthesis-3151	20	26	age	age	NOUN
aisthesis-3151	20	27	37	37	NUM
aisthesis-3151	20	28	,	,	PUNCT
aisthesis-3151	20	29	while	while	SCONJ
aisthesis-3151	20	30	the	the	DET
aisthesis-3151	20	31	more	more	ADV
aisthesis-3151	20	32	common	common	ADJ
aisthesis-3151	20	33	sporadic	sporadic	ADJ
aisthesis-3151	20	34	renal	renal	ADJ
aisthesis-3151	20	35	cell	cell	NOUN
aisthesis-3151	20	36	carcinoma	carcinoma	NOUN
aisthesis-3151	20	37	presents	present	VERB
aisthesis-3151	20	38	as	as	ADP
aisthesis-3151	20	39	a	a	DET
aisthesis-3151	20	40	solitary	solitary	ADJ
aisthesis-3151	20	41	tumor	tumor	NOUN
aisthesis-3151	20	42	at	at	ADP
aisthesis-3151	20	43	around	around	ADP
aisthesis-3151	20	44	age	age	NOUN
aisthesis-3151	20	45	61	61	NUM
aisthesis-3151	20	46	(	(	PUNCT
aisthesis-3151	20	47	pavlovich	pavlovich	PROPN
aisthesis-3151	20	48	et	et	PROPN
aisthesis-3151	20	49	al	al	PROPN
aisthesis-3151	20	50	.	.	PROPN
aisthesis-3151	20	51	,	,	PUNCT
aisthesis-3151	20	52	2003	2003	NUM
aisthesis-3151	20	53	)	)	PUNCT
aisthesis-3151	20	54	.	.	PUNCT
aisthesis-3151	21	1	regardless	regardless	ADV
aisthesis-3151	21	2	of	of	ADP
aisthesis-3151	21	3	the	the	DET
aisthesis-3151	21	4	age	age	NOUN
aisthesis-3151	21	5	of	of	ADP
aisthesis-3151	21	6	onset	onset	NOUN
aisthesis-3151	21	7	or	or	CCONJ
aisthesis-3151	21	8	etiology	etiology	NOUN
aisthesis-3151	21	9	pattern	pattern	NOUN
aisthesis-3151	21	10	,	,	PUNCT
aisthesis-3151	21	11	the	the	DET
aisthesis-3151	21	12	most	most	ADV
aisthesis-3151	21	13	common	common	ADJ
aisthesis-3151	21	14	genetic	genetic	ADJ
aisthesis-3151	21	15	de$ciency	de$ciency	NOUN
aisthesis-3151	21	16	observed	observe	VERB
aisthesis-3151	21	17	in	in	ADP
aisthesis-3151	21	18	renal	renal	ADJ
aisthesis-3151	21	19	cell	cell	NOUN
aisthesis-3151	21	20	carcinoma	carcinoma	NOUN
aisthesis-3151	21	21	is	be	AUX
aisthesis-3151	21	22	inactivation	inactivation	NOUN
aisthesis-3151	21	23	or	or	CCONJ
aisthesis-3151	21	24	mutation	mutation	NOUN
aisthesis-3151	21	25	of	of	ADP
aisthesis-3151	21	26	the	the	DET
aisthesis-3151	21	27	von	von	PROPN
aisthesis-3151	21	28	hippel	hippel	PROPN
aisthesis-3151	21	29	-	-	PUNCT
aisthesis-3151	21	30	lindau	lindau	NOUN
aisthesis-3151	21	31	(	(	PUNCT
aisthesis-3151	21	32	vhl	vhl	NOUN
aisthesis-3151	21	33	)	)	PUNCT
aisthesis-3151	21	34	tumor	tumor	NOUN
aisthesis-3151	21	35	suppressor	suppressor	NOUN
aisthesis-3151	21	36	gene	gene	NOUN
aisthesis-3151	21	37	(	(	PUNCT
aisthesis-3151	21	38	latif	latif	PROPN
aisthesis-3151	21	39	et	et	PROPN
aisthesis-3151	21	40	al	al	PROPN
aisthesis-3151	21	41	.	.	PROPN
aisthesis-3151	21	42	,	,	PUNCT
aisthesis-3151	21	43	1993	1993	NUM
aisthesis-3151	21	44	)	)	PUNCT
aisthesis-3151	21	45	.	.	PUNCT
aisthesis-3151	22	1	#	#	X
aisthesis-3151	22	2	e	e	NOUN
aisthesis-3151	22	3	protein	protein	NOUN
aisthesis-3151	22	4	encoded	encode	VERB
aisthesis-3151	22	5	by	by	ADP
aisthesis-3151	22	6	the	the	DET
aisthesis-3151	22	7	vhl	vhl	PROPN
aisthesis-3151	22	8	gene	gene	NOUN
aisthesis-3151	22	9	has	have	VERB
aisthesis-3151	22	10	numerous	numerous	ADJ
aisthesis-3151	22	11	functions	function	NOUN
aisthesis-3151	22	12	,	,	PUNCT
aisthesis-3151	22	13	but	but	CCONJ
aisthesis-3151	22	14	its	its	PRON
aisthesis-3151	22	15	role	role	NOUN
aisthesis-3151	22	16	in	in	ADP
aisthesis-3151	22	17	angiogenesis	angiogenesis	NOUN
aisthesis-3151	22	18	(	(	PUNCT
aisthesis-3151	22	19	the	the	DET
aisthesis-3151	22	20	creation	creation	NOUN
aisthesis-3151	22	21	of	of	ADP
aisthesis-3151	22	22	new	new	ADJ
aisthesis-3151	22	23	blood	blood	NOUN
aisthesis-3151	22	24	vessels	vessel	NOUN
aisthesis-3151	22	25	)	)	PUNCT
aisthesis-3151	22	26	in	in	ADP
aisthesis-3151	22	27	response	response	NOUN
aisthesis-3151	22	28	to	to	ADP
aisthesis-3151	22	29	hypoxia	hypoxia	NOUN
aisthesis-3151	22	30	has	have	AUX
aisthesis-3151	22	31	generated	generate	VERB
aisthesis-3151	22	32	several	several	ADJ
aisthesis-3151	22	33	hypotheses	hypothesis	NOUN
aisthesis-3151	22	34	on	on	ADP
aisthesis-3151	22	35	how	how	SCONJ
aisthesis-3151	22	36	to	to	PART
aisthesis-3151	22	37	treat	treat	VERB
aisthesis-3151	22	38	the	the	DET
aisthesis-3151	22	39	malignancy	malignancy	NOUN
aisthesis-3151	22	40	.	.	PUNCT
aisthesis-3151	23	1	#	#	SYM
aisthesis-3151	23	2	e	e	NOUN
aisthesis-3151	23	3	question	question	NOUN
aisthesis-3151	23	4	that	that	SCONJ
aisthesis-3151	23	5	i	i	PRON
aisthesis-3151	23	6	seek	seek	VERB
aisthesis-3151	23	7	to	to	PART
aisthesis-3151	23	8	answer	answer	VERB
aisthesis-3151	23	9	is	be	AUX
aisthesis-3151	23	10	:	:	PUNCT
aisthesis-3151	23	11	how	how	SCONJ
aisthesis-3151	23	12	have	have	VERB
aisthesis-3151	23	13	the	the	DET
aisthesis-3151	23	14	elucidation	elucidation	NOUN
aisthesis-3151	23	15	of	of	ADP
aisthesis-3151	23	16	the	the	DET
aisthesis-3151	23	17	angiogenesis	angiogenesis	NOUN
aisthesis-3151	23	18	pathway	pathway	NOUN
aisthesis-3151	23	19	and	and	CCONJ
aisthesis-3151	23	20	other	other	ADJ
aisthesis-3151	23	21	discoveries	discovery	NOUN
aisthesis-3151	23	22	on	on	ADP
aisthesis-3151	23	23	its	its	PRON
aisthesis-3151	23	24	pathology	pathology	NOUN
aisthesis-3151	23	25	changed	change	VERB
aisthesis-3151	23	26	the	the	DET
aisthesis-3151	23	27	treatment	treatment	NOUN
aisthesis-3151	23	28	of	of	ADP
aisthesis-3151	23	29	renal	renal	ADJ
aisthesis-3151	23	30	cell	cell	NOUN
aisthesis-3151	23	31	carcinoma	carcinoma	NOUN
aisthesis-3151	23	32	?	?	PUNCT
aisthesis-3151	24	1	whereas	whereas	SCONJ
aisthesis-3151	24	2	radiation	radiation	NOUN
aisthesis-3151	24	3	and/or	and/or	CCONJ
aisthesis-3151	24	4	nephrectomy	nephrectomy	NOUN
aisthesis-3151	24	5	were	be	AUX
aisthesis-3151	24	6	the	the	DET
aisthesis-3151	24	7	only	only	ADJ
aisthesis-3151	24	8	defenses	defense	NOUN
aisthesis-3151	24	9	in	in	ADP
aisthesis-3151	24	10	the	the	DET
aisthesis-3151	24	11	past	past	NOUN
aisthesis-3151	24	12	,	,	PUNCT
aisthesis-3151	24	13	modern	modern	ADJ
aisthesis-3151	24	14	management	management	NOUN
aisthesis-3151	24	15	of	of	ADP
aisthesis-3151	24	16	the	the	DET
aisthesis-3151	24	17	cancer	cancer	NOUN
aisthesis-3151	24	18	is	be	AUX
aisthesis-3151	24	19	more	more	ADV
aisthesis-3151	24	20	comprehensive	comprehensive	ADJ
aisthesis-3151	24	21	.	.	PUNCT
aisthesis-3151	25	1	a&er	a&er	ADJ
aisthesis-3151	25	2	the	the	DET
aisthesis-3151	25	3	initial	initial	ADJ
aisthesis-3151	25	4	surgery	surgery	NOUN
aisthesis-3151	25	5	or	or	CCONJ
aisthesis-3151	25	6	radiation	radiation	NOUN
aisthesis-3151	25	7	—	—	PUNCT
aisthesis-3151	25	8	depending	depend	VERB
aisthesis-3151	25	9	on	on	ADP
aisthesis-3151	25	10	whether	whether	SCONJ
aisthesis-3151	25	11	the	the	DET
aisthesis-3151	25	12	disease	disease	NOUN
aisthesis-3151	25	13	presents	present	VERB
aisthesis-3151	25	14	as	as	ADV
aisthesis-3151	25	15	metastasized	metastasized	ADJ
aisthesis-3151	25	16	or	or	CCONJ
aisthesis-3151	25	17	not	not	PART
aisthesis-3151	25	18	—	—	PUNCT
aisthesis-3151	25	19	systemic	systemic	ADJ
aisthesis-3151	25	20	pharmacological	pharmacological	ADJ
aisthesis-3151	25	21	agents	agent	NOUN
aisthesis-3151	25	22	are	be	AUX
aisthesis-3151	25	23	utilized	utilize	VERB
aisthesis-3151	25	24	to	to	PART
aisthesis-3151	25	25	prolong	prolong	VERB
aisthesis-3151	25	26	survival	survival	NOUN
aisthesis-3151	25	27	for	for	ADP
aisthesis-3151	25	28	both	both	CCONJ
aisthesis-3151	25	29	familial	familial	ADJ
aisthesis-3151	25	30	and	and	CCONJ
aisthesis-3151	25	31	sporadic	sporadic	ADJ
aisthesis-3151	25	32	cases	case	NOUN
aisthesis-3151	25	33	of	of	ADP
aisthesis-3151	25	34	renal	renal	ADJ
aisthesis-3151	25	35	cell	cell	NOUN
aisthesis-3151	25	36	carcinoma	carcinoma	NOUN
aisthesis-3151	25	37	.	.	PUNCT
aisthesis-3151	26	1	#	#	SYM
aisthesis-3151	26	2	e	e	NOUN
aisthesis-3151	26	3	aim	aim	NOUN
aisthesis-3151	26	4	of	of	ADP
aisthesis-3151	26	5	this	this	DET
aisthesis-3151	26	6	review	review	NOUN
aisthesis-3151	26	7	is	be	AUX
aisthesis-3151	26	8	to	to	PART
aisthesis-3151	26	9	present	present	VERB
aisthesis-3151	26	10	the	the	DET
aisthesis-3151	26	11	evolution	evolution	NOUN
aisthesis-3151	26	12	of	of	ADP
aisthesis-3151	26	13	pharmacological	pharmacological	ADJ
aisthesis-3151	26	14	agents	agent	NOUN
aisthesis-3151	26	15	in	in	ADP
aisthesis-3151	26	16	managing	manage	VERB
aisthesis-3151	26	17	renal	renal	ADJ
aisthesis-3151	26	18	cell	cell	NOUN
aisthesis-3151	26	19	carcinoma	carcinoma	NOUN
aisthesis-3151	26	20	.	.	PUNCT
aisthesis-3151	27	1	in	in	ADP
aisthesis-3151	27	2	its	its	PRON
aisthesis-3151	27	3	three	three	NUM
aisthesis-3151	27	4	main	main	ADJ
aisthesis-3151	27	5	sections	section	NOUN
aisthesis-3151	27	6	,	,	PUNCT
aisthesis-3151	27	7	this	this	DET
aisthesis-3151	27	8	review	review	NOUN
aisthesis-3151	27	9	will	will	AUX
aisthesis-3151	27	10	explore	explore	VERB
aisthesis-3151	27	11	cytokine	cytokine	NOUN
aisthesis-3151	27	12	immunotherapies	immunotherapy	NOUN
aisthesis-3151	27	13	utilized	utilize	VERB
aisthesis-3151	27	14	in	in	ADP
aisthesis-3151	27	15	the	the	DET
aisthesis-3151	27	16	1990s	1990	NOUN
aisthesis-3151	27	17	,	,	PUNCT
aisthesis-3151	27	18	vascular	vascular	ADJ
aisthesis-3151	27	19	endothelial	endothelial	ADJ
aisthesis-3151	27	20	growth	growth	NOUN
aisthesis-3151	27	21	factor	factor	NOUN
aisthesis-3151	27	22	-	-	PUNCT
aisthesis-3151	27	23	tyrosine	tyrosine	NOUN
aisthesis-3151	27	24	kinase	kinase	PROPN
aisthesis-3151	27	25	inhibitor	inhibitor	PROPN
aisthesis-3151	27	26	(	(	PUNCT
aisthesis-3151	27	27	vegf	vegf	PROPN
aisthesis-3151	27	28	-	-	PUNCT
aisthesis-3151	27	29	tkis	tkis	PROPN
aisthesis-3151	27	30	)	)	PUNCT
aisthesis-3151	27	31	systemic	systemic	ADJ
aisthesis-3151	27	32	therapies	therapy	NOUN
aisthesis-3151	27	33	devised	devise	VERB
aisthesis-3151	27	34	in	in	ADP
aisthesis-3151	27	35	the	the	DET
aisthesis-3151	27	36	2000s	2000s	NUM
aisthesis-3151	27	37	,	,	PUNCT
aisthesis-3151	27	38	and	and	CCONJ
aisthesis-3151	27	39	$	$	SYM
aisthesis-3151	27	40	nally	nally	ADV
aisthesis-3151	27	41	treatment	treatment	VERB
aisthesis-3151	27	42	with	with	ADP
aisthesis-3151	27	43	targeted	target	VERB
aisthesis-3151	27	44	immunotherapies	immunotherapy	NOUN
aisthesis-3151	27	45	.	.	PUNCT
aisthesis-3151	28	1	with	with	ADP
aisthesis-3151	28	2	the	the	DET
aisthesis-3151	28	3	rapid	rapid	ADJ
aisthesis-3151	28	4	pace	pace	NOUN
aisthesis-3151	28	5	of	of	ADP
aisthesis-3151	28	6	pharmaceutical	pharmaceutical	ADJ
aisthesis-3151	28	7	development	development	NOUN
aisthesis-3151	28	8	,	,	PUNCT
aisthesis-3151	28	9	the	the	DET
aisthesis-3151	28	10	prognosis	prognosis	NOUN
aisthesis-3151	28	11	for	for	ADP
aisthesis-3151	28	12	renal	renal	ADJ
aisthesis-3151	28	13	cell	cell	NOUN
aisthesis-3151	28	14	carcinoma	carcinoma	NOUN
aisthesis-3151	28	15	continues	continue	VERB
aisthesis-3151	28	16	to	to	PART
aisthesis-3151	28	17	improve	improve	VERB
aisthesis-3151	28	18	.	.	PUNCT
aisthesis-3151	29	1	1990s	1990s	NUM
aisthesis-3151	29	2	:	:	PUNCT
aisthesis-3151	29	3	!	!	PUNCT
aisthesis-3151	30	1	e	e	NOUN
aisthesis-3151	30	2	age	age	NOUN
aisthesis-3151	30	3	of	of	ADP
aisthesis-3151	30	4	cytokine	cytokine	NOUN
aisthesis-3151	30	5	immunotherapies	immunotherapy	NOUN
aisthesis-3151	30	6	between	between	ADP
aisthesis-3151	30	7	1900	1900	NUM
aisthesis-3151	30	8	and	and	CCONJ
aisthesis-3151	30	9	1987	1987	NUM
aisthesis-3151	30	10	,	,	PUNCT
aisthesis-3151	30	11	sporadic	sporadic	ADJ
aisthesis-3151	30	12	cases	case	NOUN
aisthesis-3151	30	13	of	of	ADP
aisthesis-3151	30	14	spontaneous	spontaneous	ADJ
aisthesis-3151	30	15	regression	regression	NOUN
aisthesis-3151	30	16	of	of	ADP
aisthesis-3151	30	17	renal	renal	ADJ
aisthesis-3151	30	18	cell	cell	NOUN
aisthesis-3151	30	19	carcinoma	carcinoma	NOUN
aisthesis-3151	30	20	were	be	AUX
aisthesis-3151	30	21	detected	detect	VERB
aisthesis-3151	30	22	in	in	ADP
aisthesis-3151	30	23	patients	patient	NOUN
aisthesis-3151	30	24	who	who	PRON
aisthesis-3151	30	25	were	be	AUX
aisthesis-3151	30	26	simultaneously	simultaneously	ADV
aisthesis-3151	30	27	experiencing	experience	VERB
aisthesis-3151	30	28	bacterial	bacterial	ADJ
aisthesis-3151	30	29	infections	infection	NOUN
aisthesis-3151	30	30	(	(	PUNCT
aisthesis-3151	30	31	challis	challi	NOUN
aisthesis-3151	30	32	&	&	CCONJ
aisthesis-3151	30	33	stam	stam	PROPN
aisthesis-3151	30	34	,	,	PUNCT
aisthesis-3151	30	35	1989	1989	NUM
aisthesis-3151	30	36	)	)	PUNCT
aisthesis-3151	30	37	.	.	PUNCT
aisthesis-3151	31	1	clinicians	clinician	NOUN
aisthesis-3151	31	2	hypothesized	hypothesize	VERB
aisthesis-3151	31	3	that	that	SCONJ
aisthesis-3151	31	4	such	such	ADJ
aisthesis-3151	31	5	cases	case	NOUN
aisthesis-3151	31	6	,	,	PUNCT
aisthesis-3151	31	7	although	although	SCONJ
aisthesis-3151	31	8	rare	rare	ADJ
aisthesis-3151	31	9	,	,	PUNCT
aisthesis-3151	31	10	may	may	AUX
aisthesis-3151	31	11	have	have	AUX
aisthesis-3151	31	12	arisen	arise	VERB
aisthesis-3151	31	13	due	due	ADP
aisthesis-3151	31	14	to	to	ADP
aisthesis-3151	31	15	the	the	DET
aisthesis-3151	31	16	activation	activation	NOUN
aisthesis-3151	31	17	of	of	ADP
aisthesis-3151	31	18	the	the	DET
aisthesis-3151	31	19	patients	patient	NOUN
aisthesis-3151	31	20	’	’	PART
aisthesis-3151	31	21	immune	immune	ADJ
aisthesis-3151	31	22	system	system	NOUN
aisthesis-3151	31	23	in	in	ADP
aisthesis-3151	31	24	response	response	NOUN
aisthesis-3151	31	25	to	to	ADP
aisthesis-3151	31	26	the	the	DET
aisthesis-3151	31	27	bacterial	bacterial	ADJ
aisthesis-3151	31	28	infection	infection	NOUN
aisthesis-3151	31	29	.	.	PUNCT
aisthesis-3151	32	1	such	such	ADJ
aisthesis-3151	32	2	hypotheses	hypothesis	NOUN
aisthesis-3151	32	3	led	lead	VERB
aisthesis-3151	32	4	to	to	ADP
aisthesis-3151	32	5	the	the	DET
aisthesis-3151	32	6	labeling	labeling	NOUN
aisthesis-3151	32	7	of	of	ADP
aisthesis-3151	32	8	renal	renal	ADJ
aisthesis-3151	32	9	cell	cell	NOUN
aisthesis-3151	32	10	carcinoma	carcinoma	NOUN
aisthesis-3151	32	11	as	as	ADP
aisthesis-3151	32	12	“	"	PUNCT
aisthesis-3151	32	13	immunogenic	immunogenic	ADJ
aisthesis-3151	32	14	.	.	PUNCT
aisthesis-3151	32	15	”	"	PUNCT
aisthesis-3151	33	1	once	once	ADV
aisthesis-3151	33	2	engaged	engage	VERB
aisthesis-3151	33	3	to	to	PART
aisthesis-3151	33	4	combat	combat	VERB
aisthesis-3151	33	5	the	the	DET
aisthesis-3151	33	6	bacterial	bacterial	ADJ
aisthesis-3151	33	7	infection	infection	NOUN
aisthesis-3151	33	8	,	,	PUNCT
aisthesis-3151	33	9	the	the	DET
aisthesis-3151	33	10	immune	immune	ADJ
aisthesis-3151	33	11	system	system	NOUN
aisthesis-3151	33	12	likely	likely	ADV
aisthesis-3151	33	13	discovered	discover	VERB
aisthesis-3151	33	14	the	the	DET
aisthesis-3151	33	15	cancerous	cancerous	ADJ
aisthesis-3151	33	16	cells	cell	NOUN
aisthesis-3151	33	17	in	in	ADP
aisthesis-3151	33	18	the	the	DET
aisthesis-3151	33	19	body	body	NOUN
aisthesis-3151	33	20	and	and	CCONJ
aisthesis-3151	33	21	generated	generate	VERB
aisthesis-3151	33	22	an	an	DET
aisthesis-3151	33	23	immune	immune	ADJ
aisthesis-3151	33	24	response	response	NOUN
aisthesis-3151	33	25	that	that	PRON
aisthesis-3151	33	26	ultimately	ultimately	ADV
aisthesis-3151	33	27	induced	induce	VERB
aisthesis-3151	33	28	cancer	cancer	NOUN
aisthesis-3151	33	29	regression	regression	NOUN
aisthesis-3151	33	30	.	.	PUNCT
aisthesis-3151	34	1	scientists	scientist	NOUN
aisthesis-3151	34	2	and	and	CCONJ
aisthesis-3151	34	3	clinicians	clinician	NOUN
aisthesis-3151	34	4	subsequently	subsequently	ADV
aisthesis-3151	34	5	tested	test	VERB
aisthesis-3151	34	6	this	this	DET
aisthesis-3151	34	7	hypothesis	hypothesis	NOUN
aisthesis-3151	34	8	by	by	ADP
aisthesis-3151	34	9	developing	develop	VERB
aisthesis-3151	34	10	cytokine	cytokine	NOUN
aisthesis-3151	34	11	immunotherapies	immunotherapy	NOUN
aisthesis-3151	34	12	.	.	PUNCT
aisthesis-3151	35	1	in	in	ADP
aisthesis-3151	35	2	general	general	ADJ
aisthesis-3151	35	3	,	,	PUNCT
aisthesis-3151	35	4	cytokine	cytokine	ADJ
aisthesis-3151	35	5	immunotherapies	immunotherapy	NOUN
aisthesis-3151	35	6	generate	generate	VERB
aisthesis-3151	35	7	a	a	DET
aisthesis-3151	35	8	widespread	widespread	ADJ
aisthesis-3151	35	9	activation	activation	NOUN
aisthesis-3151	35	10	of	of	ADP
aisthesis-3151	35	11	immune	immune	ADJ
aisthesis-3151	35	12	cells	cell	NOUN
aisthesis-3151	35	13	in	in	ADP
aisthesis-3151	35	14	the	the	DET
aisthesis-3151	35	15	body	body	NOUN
aisthesis-3151	35	16	,	,	PUNCT
aisthesis-3151	35	17	such	such	ADJ
aisthesis-3151	35	18	as	as	ADP
aisthesis-3151	35	19	b	b	PROPN
aisthesis-3151	35	20	cells	cell	NOUN
aisthesis-3151	35	21	,	,	PUNCT
aisthesis-3151	35	22	t	t	NOUN
aisthesis-3151	35	23	cells	cell	NOUN
aisthesis-3151	35	24	,	,	PUNCT
aisthesis-3151	35	25	and	and	CCONJ
aisthesis-3151	35	26	macrophages	macrophage	NOUN
aisthesis-3151	35	27	,	,	PUNCT
aisthesis-3151	35	28	that	that	PRON
aisthesis-3151	35	29	ultimately	ultimately	ADV
aisthesis-3151	35	30	target	target	VERB
aisthesis-3151	35	31	the	the	DET
aisthesis-3151	35	32	cancer	cancer	NOUN
aisthesis-3151	35	33	.	.	PUNCT
aisthesis-3151	36	1	by	by	ADP
aisthesis-3151	36	2	the	the	DET
aisthesis-3151	36	3	early	early	ADJ
aisthesis-3151	36	4	1990s	1990	NOUN
aisthesis-3151	36	5	,	,	PUNCT
aisthesis-3151	36	6	cytokine	cytokine	NOUN
aisthesis-3151	36	7	immunotherapies	immunotherapy	NOUN
aisthesis-3151	36	8	were	be	AUX
aisthesis-3151	36	9	primarily	primarily	ADV
aisthesis-3151	36	10	used	use	VERB
aisthesis-3151	36	11	in	in	ADP
aisthesis-3151	36	12	the	the	DET
aisthesis-3151	36	13	post	post	ADJ
aisthesis-3151	36	14	-	-	ADJ
aisthesis-3151	36	15	surgery	surgery	ADJ
aisthesis-3151	36	16	and/or	and/or	CCONJ
aisthesis-3151	36	17	metastatic	metastatic	ADJ
aisthesis-3151	36	18	renal	renal	ADJ
aisthesis-3151	36	19	cell	cell	NOUN
aisthesis-3151	36	20	carcinoma	carcinoma	NOUN
aisthesis-3151	36	21	setting	set	VERB
aisthesis-3151	36	22	with	with	ADP
aisthesis-3151	36	23	the	the	DET
aisthesis-3151	36	24	goal	goal	NOUN
aisthesis-3151	36	25	of	of	ADP
aisthesis-3151	36	26	reducing	reduce	VERB
aisthesis-3151	36	27	the	the	DET
aisthesis-3151	36	28	intensity	intensity	NOUN
aisthesis-3151	36	29	of	of	ADP
aisthesis-3151	36	30	the	the	DET
aisthesis-3151	36	31	cancer	cancer	NOUN
aisthesis-3151	36	32	.	.	PUNCT
aisthesis-3151	37	1	two	two	NUM
aisthesis-3151	37	2	of	of	ADP
aisthesis-3151	37	3	the	the	DET
aisthesis-3151	37	4	most	most	ADV
aisthesis-3151	37	5	signi$cant	signi$cant	NOUN
aisthesis-3151	37	6	drugs	drug	NOUN
aisthesis-3151	37	7	developed	develop	VERB
aisthesis-3151	37	8	were	be	AUX
aisthesis-3151	37	9	synthetic	synthetic	ADJ
aisthesis-3151	37	10	high	high	ADJ
aisthesis-3151	37	11	dose	dose	NOUN
aisthesis-3151	37	12	-	-	PUNCT
aisthesis-3151	37	13	interleukin	interleukin	NOUN
aisthesis-3151	37	14	2	2	NUM
aisthesis-3151	37	15	(	(	PUNCT
aisthesis-3151	37	16	hd	hd	NOUN
aisthesis-3151	37	17	-	-	NOUN
aisthesis-3151	37	18	il2	il2	NOUN
aisthesis-3151	37	19	)	)	PUNCT
aisthesis-3151	37	20	,	,	PUNCT
aisthesis-3151	37	21	and	and	CCONJ
aisthesis-3151	37	22	interferon	interferon	ADJ
aisthesis-3151	37	23	alfa-2	alfa-2	ADJ
aisthesis-3151	37	24	'	'	NUM
aisthesis-3151	37	25	,	,	PUNCT
aisthesis-3151	37	26	o&en	o&en	ADV
aisthesis-3151	37	27	denoted	denote	VERB
aisthesis-3151	37	28	as	as	ADP
aisthesis-3151	37	29	ifn-	ifn-	NOUN
aisthesis-3151	37	30	'	'	PUNCT
aisthesis-3151	37	31	in	in	ADP
aisthesis-3151	37	32	the	the	DET
aisthesis-3151	37	33	clinic	clinic	NOUN
aisthesis-3151	37	34	.	.	PUNCT
aisthesis-3151	38	1	mechanistically	mechanistically	ADV
aisthesis-3151	38	2	,	,	PUNCT
aisthesis-3151	38	3	these	these	DET
aisthesis-3151	38	4	two	two	NUM
aisthesis-3151	38	5	therapies	therapy	NOUN
aisthesis-3151	38	6	di!er	di!er	PROPN
aisthesis-3151	38	7	.	.	PUNCT
aisthesis-3151	39	1	hd	hd	NOUN
aisthesis-3151	39	2	-	-	NOUN
aisthesis-3151	39	3	il2	il2	NOUN
aisthesis-3151	39	4	induces	induce	VERB
aisthesis-3151	39	5	the	the	DET
aisthesis-3151	39	6	proliferation	proliferation	NOUN
aisthesis-3151	39	7	of	of	ADP
aisthesis-3151	39	8	immune	immune	ADJ
aisthesis-3151	39	9	cells	cell	NOUN
aisthesis-3151	39	10	and	and	CCONJ
aisthesis-3151	39	11	stimulates	stimulate	VERB
aisthesis-3151	39	12	these	these	DET
aisthesis-3151	39	13	cells	cell	NOUN
aisthesis-3151	39	14	to	to	PART
aisthesis-3151	39	15	target	target	VERB
aisthesis-3151	39	16	the	the	DET
aisthesis-3151	39	17	cancer	cancer	NOUN
aisthesis-3151	39	18	,	,	PUNCT
aisthesis-3151	39	19	while	while	SCONJ
aisthesis-3151	39	20	ifn-	ifn-	PRON
aisthesis-3151	39	21	'	'	PUNCT
aisthesis-3151	39	22	makes	make	VERB
aisthesis-3151	39	23	tumor	tumor	NOUN
aisthesis-3151	39	24	cells	cell	NOUN
aisthesis-3151	39	25	more	more	ADV
aisthesis-3151	39	26	immunogenic	immunogenic	ADJ
aisthesis-3151	39	27	.	.	PUNCT
aisthesis-3151	40	1	in	in	ADP
aisthesis-3151	40	2	murine	murine	ADJ
aisthesis-3151	40	3	models	model	NOUN
aisthesis-3151	40	4	,	,	PUNCT
aisthesis-3151	40	5	a	a	DET
aisthesis-3151	40	6	combination	combination	NOUN
aisthesis-3151	40	7	of	of	ADP
aisthesis-3151	40	8	hd	hd	NOUN
aisthesis-3151	40	9	-	-	NOUN
aisthesis-3151	40	10	il2	il2	NOUN
aisthesis-3151	40	11	and	and	CCONJ
aisthesis-3151	40	12	ifn-	ifn-	X
aisthesis-3151	40	13	'	'	PUNCT
aisthesis-3151	40	14	was	be	AUX
aisthesis-3151	40	15	found	find	VERB
aisthesis-3151	40	16	to	to	PART
aisthesis-3151	40	17	be	be	AUX
aisthesis-3151	40	18	correlated	correlate	VERB
aisthesis-3151	40	19	with	with	ADP
aisthesis-3151	40	20	anti	anti	ADJ
aisthesis-3151	40	21	-	-	ADJ
aisthesis-3151	40	22	tumor	tumor	ADJ
aisthesis-3151	40	23	activity	activity	NOUN
aisthesis-3151	40	24	(	(	PUNCT
aisthesis-3151	40	25	brunda	brunda	NOUN
aisthesis-3151	40	26	et	et	PROPN
aisthesis-3151	40	27	al	al	PROPN
aisthesis-3151	40	28	.	.	PROPN
aisthesis-3151	40	29	,	,	PUNCT
aisthesis-3151	40	30	1987	1987	NUM
aisthesis-3151	40	31	)	)	PUNCT
aisthesis-3151	40	32	.	.	PUNCT
aisthesis-3151	41	1	to	to	PART
aisthesis-3151	41	2	assess	assess	VERB
aisthesis-3151	41	3	whether	whether	SCONJ
aisthesis-3151	41	4	the	the	DET
aisthesis-3151	41	5	same	same	ADJ
aisthesis-3151	41	6	would	would	AUX
aisthesis-3151	41	7	hold	hold	VERB
aisthesis-3151	41	8	in	in	ADP
aisthesis-3151	41	9	metastatic	metastatic	ADJ
aisthesis-3151	41	10	renal	renal	ADJ
aisthesis-3151	41	11	cell	cell	NOUN
aisthesis-3151	41	12	carcinoma	carcinoma	NOUN
aisthesis-3151	41	13	patients	patient	NOUN
aisthesis-3151	41	14	,	,	PUNCT
aisthesis-3151	41	15	a	a	DET
aisthesis-3151	41	16	phase	phase	NOUN
aisthesis-3151	41	17	ii	ii	NOUN
aisthesis-3151	41	18	clinical	clinical	ADJ
aisthesis-3151	41	19	trial	trial	NOUN
aisthesis-3151	41	20	was	be	AUX
aisthesis-3151	41	21	devised	devise	VERB
aisthesis-3151	41	22	to	to	PART
aisthesis-3151	41	23	compare	compare	VERB
aisthesis-3151	41	24	survival	survival	NOUN
aisthesis-3151	41	25	and	and	CCONJ
aisthesis-3151	41	26	toxicities	toxicity	NOUN
aisthesis-3151	41	27	in	in	ADP
aisthesis-3151	41	28	patients	patient	NOUN
aisthesis-3151	41	29	treated	treat	VERB
aisthesis-3151	41	30	with	with	ADP
aisthesis-3151	41	31	hd	hd	NOUN
aisthesis-3151	41	32	-	-	NOUN
aisthesis-3151	41	33	il2	il2	NOUN
aisthesis-3151	41	34	alone	alone	ADV
aisthesis-3151	41	35	or	or	CCONJ
aisthesis-3151	41	36	with	with	ADP
aisthesis-3151	41	37	the	the	DET
aisthesis-3151	41	38	hd	hd	NOUN
aisthesis-3151	41	39	-	-	NOUN
aisthesis-3151	41	40	il2	il2	NOUN
aisthesis-3151	41	41	/	/	SYM
aisthesis-3151	41	42	ifn-	ifn-	NOUN
aisthesis-3151	41	43	'	'	PUNCT
aisthesis-3151	41	44	combination	combination	NOUN
aisthesis-3151	41	45	(	(	PUNCT
aisthesis-3151	41	46	atkins	atkin	NOUN
aisthesis-3151	41	47	et	et	PROPN
aisthesis-3151	41	48	al	al	PROPN
aisthesis-3151	41	49	.	.	PROPN
aisthesis-3151	41	50	,	,	PUNCT
aisthesis-3151	41	51	1993	1993	NUM
aisthesis-3151	41	52	)	)	PUNCT
aisthesis-3151	41	53	.	.	PUNCT
aisthesis-3151	42	1	atkins	atkins	PROPN
aisthesis-3151	42	2	et	et	PROPN
aisthesis-3151	42	3	al	al	PROPN
aisthesis-3151	42	4	.	.	PROPN
aisthesis-3151	43	1	(	(	PUNCT
aisthesis-3151	43	2	1993	1993	NUM
aisthesis-3151	43	3	)	)	PUNCT
aisthesis-3151	43	4	hypothesized	hypothesize	VERB
aisthesis-3151	43	5	that	that	SCONJ
aisthesis-3151	43	6	,	,	PUNCT
aisthesis-3151	43	7	given	give	VERB
aisthesis-3151	43	8	unequivocal	unequivocal	ADJ
aisthesis-3151	43	9	evidence	evidence	NOUN
aisthesis-3151	43	10	of	of	ADP
aisthesis-3151	43	11	anti	anti	ADJ
aisthesis-3151	43	12	-	-	ADJ
aisthesis-3151	43	13	tumor	tumor	ADJ
aisthesis-3151	43	14	activity	activity	NOUN
aisthesis-3151	43	15	of	of	ADP
aisthesis-3151	43	16	the	the	DET
aisthesis-3151	43	17	hd	hd	NOUN
aisthesis-3151	43	18	-	-	NOUN
aisthesis-3151	43	19	il2	il2	NOUN
aisthesis-3151	43	20	/	/	SYM
aisthesis-3151	43	21	ifn-	ifn-	NOUN
aisthesis-3151	43	22	'	'	PUNCT
aisthesis-3151	43	23	combination	combination	NOUN
aisthesis-3151	43	24	in	in	ADP
aisthesis-3151	43	25	in	in	ADP
aisthesis-3151	43	26	vivo	vivo	ADJ
aisthesis-3151	43	27	studies	study	NOUN
aisthesis-3151	43	28	,	,	PUNCT
aisthesis-3151	43	29	similar	similar	ADJ
aisthesis-3151	43	30	trends	trend	NOUN
aisthesis-3151	43	31	would	would	AUX
aisthesis-3151	43	32	be	be	AUX
aisthesis-3151	43	33	seen	see	VERB
aisthesis-3151	43	34	in	in	ADP
aisthesis-3151	43	35	humans	human	NOUN
aisthesis-3151	43	36	.	.	PUNCT
aisthesis-3151	44	1	in	in	ADP
aisthesis-3151	44	2	the	the	DET
aisthesis-3151	44	3	phase	phase	NOUN
aisthesis-3151	44	4	ii	ii	NOUN
aisthesis-3151	44	5	trial	trial	NOUN
aisthesis-3151	44	6	,	,	PUNCT
aisthesis-3151	44	7	atkins	atkins	PROPN
aisthesis-3151	44	8	et	et	PROPN
aisthesis-3151	44	9	al	al	PROPN
aisthesis-3151	44	10	.	.	PROPN
aisthesis-3151	44	11	included	include	VERB
aisthesis-3151	44	12	99	99	NUM
aisthesis-3151	44	13	patients	patient	NOUN
aisthesis-3151	44	14	with	with	ADP
aisthesis-3151	44	15	metastatic	metastatic	ADJ
aisthesis-3151	44	16	renal	renal	ADJ
aisthesis-3151	44	17	cell	cell	NOUN
aisthesis-3151	44	18	carcinoma	carcinoma	NOUN
aisthesis-3151	44	19	.	.	PUNCT
aisthesis-3151	45	1	28	28	NUM
aisthesis-3151	45	2	patients	patient	NOUN
aisthesis-3151	45	3	were	be	AUX
aisthesis-3151	45	4	administered	administer	VERB
aisthesis-3151	45	5	the	the	DET
aisthesis-3151	45	6	combination	combination	NOUN
aisthesis-3151	45	7	hd	hd	NOUN
aisthesis-3151	45	8	-	-	NOUN
aisthesis-3151	45	9	il2	il2	NOUN
aisthesis-3151	45	10	/	/	SYM
aisthesis-3151	45	11	ifn-	ifn-	NOUN
aisthesis-3151	45	12	'	'	PUNCT
aisthesis-3151	45	13	treatment	treatment	NOUN
aisthesis-3151	45	14	,	,	PUNCT
aisthesis-3151	45	15	and	and	CCONJ
aisthesis-3151	45	16	71	71	NUM
aisthesis-3151	45	17	patients	patient	NOUN
aisthesis-3151	45	18	were	be	AUX
aisthesis-3151	45	19	administered	administer	VERB
aisthesis-3151	45	20	hdil2	hdil2	NOUN
aisthesis-3151	45	21	treatment	treatment	NOUN
aisthesis-3151	45	22	alone	alone	ADV
aisthesis-3151	45	23	.	.	PUNCT
aisthesis-3151	46	1	researchers	researcher	NOUN
aisthesis-3151	46	2	then	then	ADV
aisthesis-3151	46	3	followed	follow	VERB
aisthesis-3151	46	4	up	up	ADP
aisthesis-3151	46	5	with	with	ADP
aisthesis-3151	46	6	all	all	DET
aisthesis-3151	46	7	patients	patient	NOUN
aisthesis-3151	46	8	for	for	ADP
aisthesis-3151	46	9	26	26	NUM
aisthesis-3151	46	10	months	month	NOUN
aisthesis-3151	46	11	to	to	PART
aisthesis-3151	46	12	track	track	VERB
aisthesis-3151	46	13	survival	survival	NOUN
aisthesis-3151	46	14	,	,	PUNCT
aisthesis-3151	46	15	encountered	encounter	VERB
aisthesis-3151	46	16	toxicities	toxicity	NOUN
aisthesis-3151	46	17	,	,	PUNCT
aisthesis-3151	46	18	and	and	CCONJ
aisthesis-3151	46	19	response	response	NOUN
aisthesis-3151	46	20	.	.	PUNCT
aisthesis-3151	47	1	it	it	PRON
aisthesis-3151	47	2	was	be	AUX
aisthesis-3151	47	3	found	find	VERB
aisthesis-3151	47	4	that	that	SCONJ
aisthesis-3151	47	5	,	,	PUNCT
aisthesis-3151	47	6	although	although	SCONJ
aisthesis-3151	47	7	median	median	ADJ
aisthesis-3151	47	8	survival	survival	NOUN
aisthesis-3151	47	9	rates	rate	NOUN
aisthesis-3151	47	10	were	be	AUX
aisthesis-3151	47	11	nearly	nearly	ADV
aisthesis-3151	47	12	equal	equal	ADJ
aisthesis-3151	47	13	for	for	ADP
aisthesis-3151	47	14	the	the	DET
aisthesis-3151	47	15	hd	hd	NOUN
aisthesis-3151	47	16	-	-	NOUN
aisthesis-3151	47	17	il2	il2	NOUN
aisthesis-3151	47	18	and	and	CCONJ
aisthesis-3151	47	19	hd	hd	NOUN
aisthesis-3151	47	20	-	-	PUNCT
aisthesis-3151	47	21	il2/	il2/	ADJ
aisthesis-3151	47	22	ifn-	ifn-	NOUN
aisthesis-3151	47	23	'	'	PUNCT
aisthesis-3151	47	24	arms	arm	NOUN
aisthesis-3151	47	25	(	(	PUNCT
aisthesis-3151	47	26	figure	figure	NOUN
aisthesis-3151	47	27	2	2	NUM
aisthesis-3151	47	28	;	;	PUNCT
aisthesis-3151	47	29	15.5	15.5	NUM
aisthesis-3151	47	30	months	month	NOUN
aisthesis-3151	47	31	vs.	vs.	ADP
aisthesis-3151	47	32	16	16	NUM
aisthesis-3151	47	33	months	month	NOUN
aisthesis-3151	47	34	,	,	PUNCT
aisthesis-3151	47	35	respectively	respectively	ADV
aisthesis-3151	47	36	)	)	PUNCT
aisthesis-3151	47	37	,	,	PUNCT
aisthesis-3151	47	38	response	response	NOUN
aisthesis-3151	47	39	rates	rate	NOUN
aisthesis-3151	47	40	were	be	AUX
aisthesis-3151	47	41	higher	high	ADJ
aisthesis-3151	47	42	for	for	ADP
aisthesis-3151	47	43	the	the	DET
aisthesis-3151	47	44	hdil2	hdil2	NOUN
aisthesis-3151	47	45	arm	arm	NOUN
aisthesis-3151	47	46	(	(	PUNCT
aisthesis-3151	47	47	17	17	NUM
aisthesis-3151	47	48	%	%	NOUN
aisthesis-3151	47	49	vs.	vs.	ADP
aisthesis-3151	47	50	11	11	NUM
aisthesis-3151	47	51	%	%	NOUN
aisthesis-3151	47	52	,	,	PUNCT
aisthesis-3151	47	53	respectively	respectively	ADV
aisthesis-3151	47	54	)	)	PUNCT
aisthesis-3151	47	55	.	.	PUNCT
aisthesis-3151	48	1	furthermore	furthermore	ADV
aisthesis-3151	48	2	,	,	PUNCT
aisthesis-3151	48	3	di!erences	di!erence	NOUN
aisthesis-3151	48	4	in	in	ADP
aisthesis-3151	48	5	toxicity	toxicity	NOUN
aisthesis-3151	48	6	were	be	AUX
aisthesis-3151	48	7	observed	observe	VERB
aisthesis-3151	48	8	.	.	PUNCT
aisthesis-3151	49	1	signi$cantly	signi$cantly	ADV
aisthesis-3151	49	2	more	more	ADJ
aisthesis-3151	49	3	neutropenia	neutropenia	NOUN
aisthesis-3151	49	4	(	(	PUNCT
aisthesis-3151	49	5	low	low	ADJ
aisthesis-3151	49	6	white	white	ADJ
aisthesis-3151	49	7	blood	blood	NOUN
aisthesis-3151	49	8	cell	cell	NOUN
aisthesis-3151	49	9	count	count	NOUN
aisthesis-3151	49	10	)	)	PUNCT
aisthesis-3151	49	11	and	and	CCONJ
aisthesis-3151	49	12	myocarditis	myocarditis	ADJ
aisthesis-3151	49	13	/	/	SYM
aisthesis-3151	49	14	ischemia	ischemia	NOUN
aisthesis-3151	49	15	(	(	PUNCT
aisthesis-3151	49	16	reduced	reduce	VERB
aisthesis-3151	49	17	blood	blood	NOUN
aisthesis-3151	49	18	supply	supply	NOUN
aisthesis-3151	49	19	to	to	ADP
aisthesis-3151	49	20	the	the	DET
aisthesis-3151	49	21	heart	heart	NOUN
aisthesis-3151	49	22	)	)	PUNCT
aisthesis-3151	49	23	were	be	AUX
aisthesis-3151	49	24	noted	note	VERB
aisthesis-3151	49	25	on	on	ADP
aisthesis-3151	49	26	the	the	DET
aisthesis-3151	49	27	hd	hd	NOUN
aisthesis-3151	49	28	-	-	NOUN
aisthesis-3151	49	29	il2	il2	NOUN
aisthesis-3151	49	30	/	/	SYM
aisthesis-3151	49	31	ifn-	ifn-	NOUN
aisthesis-3151	49	32	'	'	PUNCT
aisthesis-3151	49	33	arm	arm	NOUN
aisthesis-3151	49	34	,	,	PUNCT
aisthesis-3151	49	35	while	while	SCONJ
aisthesis-3151	49	36	serum	serum	NOUN
aisthesis-3151	49	37	bilirubin	bilirubin	NOUN
aisthesis-3151	49	38	was	be	AUX
aisthesis-3151	49	39	signi$cantly	signi$cantly	ADV
aisthesis-3151	49	40	elevated	elevate	VERB
aisthesis-3151	49	41	(	(	PUNCT
aisthesis-3151	49	42	an	an	DET
aisthesis-3151	49	43	indicator	indicator	NOUN
aisthesis-3151	49	44	of	of	ADP
aisthesis-3151	49	45	liver	liver	NOUN
aisthesis-3151	49	46	damage	damage	NOUN
aisthesis-3151	49	47	)	)	PUNCT
aisthesis-3151	49	48	in	in	ADP
aisthesis-3151	49	49	patients	patient	NOUN
aisthesis-3151	49	50	on	on	ADP
aisthesis-3151	49	51	the	the	DET
aisthesis-3151	49	52	hd	hd	NOUN
aisthesis-3151	49	53	-	-	ADJ
aisthesis-3151	49	54	il2	il2	NOUN
aisthesis-3151	49	55	arm	arm	NOUN
aisthesis-3151	49	56	.	.	PUNCT
aisthesis-3151	50	1	nevertheless	nevertheless	ADV
aisthesis-3151	50	2	,	,	PUNCT
aisthesis-3151	50	3	improved	improved	ADJ
aisthesis-3151	50	4	response	response	NOUN
aisthesis-3151	50	5	rates	rate	NOUN
aisthesis-3151	50	6	with	with	ADP
aisthesis-3151	50	7	figure	figure	NOUN
aisthesis-3151	50	8	2	2	NUM
aisthesis-3151	50	9	:	:	PUNCT
aisthesis-3151	50	10	response	response	NOUN
aisthesis-3151	50	11	to	to	ADP
aisthesis-3151	50	12	di"erent	di"erent	NOUN
aisthesis-3151	50	13	cytokine	cytokine	NOUN
aisthesis-3151	50	14	immunotherapy	immunotherapy	NOUN
aisthesis-3151	50	15	treatment	treatment	NOUN
aisthesis-3151	50	16	regimens	regimen	NOUN
aisthesis-3151	50	17	in	in	ADP
aisthesis-3151	50	18	renal	renal	ADJ
aisthesis-3151	50	19	cell	cell	NOUN
aisthesis-3151	50	20	carcinoma	carcinoma	NOUN
aisthesis-3151	50	21	.	.	PUNCT
aisthesis-3151	51	1	patients	patient	NOUN
aisthesis-3151	51	2	were	be	AUX
aisthesis-3151	51	3	given	give	VERB
aisthesis-3151	51	4	either	either	CCONJ
aisthesis-3151	51	5	(	(	PUNCT
aisthesis-3151	51	6	a	a	X
aisthesis-3151	51	7	)	)	PUNCT
aisthesis-3151	51	8	a	a	DET
aisthesis-3151	51	9	combination	combination	NOUN
aisthesis-3151	51	10	of	of	ADP
aisthesis-3151	51	11	hd	hd	NOUN
aisthesis-3151	51	12	-	-	NOUN
aisthesis-3151	51	13	il2	il2	NOUN
aisthesis-3151	51	14	and	and	CCONJ
aisthesis-3151	51	15	ifn-	ifn-	X
aisthesis-3151	51	16	'	'	PUNCT
aisthesis-3151	51	17	(	(	PUNCT
aisthesis-3151	51	18	n=28	n=28	NOUN
aisthesis-3151	51	19	)	)	PUNCT
aisthesis-3151	51	20	,	,	PUNCT
aisthesis-3151	51	21	or	or	CCONJ
aisthesis-3151	51	22	(	(	PUNCT
aisthesis-3151	51	23	b	b	NOUN
aisthesis-3151	51	24	)	)	PUNCT
aisthesis-3151	51	25	hd	hd	NOUN
aisthesis-3151	51	26	-	-	NOUN
aisthesis-3151	51	27	il2	il2	NOUN
aisthesis-3151	51	28	exclusively	exclusively	ADV
aisthesis-3151	51	29	(	(	PUNCT
aisthesis-3151	51	30	n=71	n=71	NOUN
aisthesis-3151	51	31	)	)	PUNCT
aisthesis-3151	51	32	via	via	ADP
aisthesis-3151	51	33	bolus	bolus	ADJ
aisthesis-3151	51	34	intravenous	intravenous	ADJ
aisthesis-3151	51	35	injection	injection	NOUN
aisthesis-3151	51	36	every	every	DET
aisthesis-3151	51	37	8	8	NUM
aisthesis-3151	51	38	hours	hour	NOUN
aisthesis-3151	51	39	,	,	PUNCT
aisthesis-3151	51	40	days	day	NOUN
aisthesis-3151	51	41	1	1	NUM
aisthesis-3151	51	42	to	to	PART
aisthesis-3151	51	43	5	5	NUM
aisthesis-3151	51	44	and	and	CCONJ
aisthesis-3151	51	45	15	15	NUM
aisthesis-3151	51	46	to	to	PART
aisthesis-3151	51	47	19	19	NUM
aisthesis-3151	51	48	.	.	PUNCT
aisthesis-3151	51	49	hd	hd	NOUN
aisthesis-3151	51	50	-	-	NOUN
aisthesis-3151	51	51	il2	il2	NOUN
aisthesis-3151	51	52	was	be	AUX
aisthesis-3151	51	53	given	give	VERB
aisthesis-3151	51	54	at	at	ADP
aisthesis-3151	51	55	a	a	DET
aisthesis-3151	51	56	dosage	dosage	NOUN
aisthesis-3151	51	57	of	of	ADP
aisthesis-3151	51	58	0.8	0.8	NUM
aisthesis-3151	51	59	mg	mg	PROPN
aisthesis-3151	51	60	/	/	SYM
aisthesis-3151	51	61	m2	m2	PROPN
aisthesis-3151	51	62	and	and	CCONJ
aisthesis-3151	51	63	ifn-	ifn-	X
aisthesis-3151	51	64	'	'	PUNCT
aisthesis-3151	51	65	at	at	ADP
aisthesis-3151	51	66	a	a	DET
aisthesis-3151	51	67	dosage	dosage	NOUN
aisthesis-3151	51	68	of	of	ADP
aisthesis-3151	51	69	3	3	NUM
aisthesis-3151	51	70	x	x	SYM
aisthesis-3151	51	71	10(6	10(6	NOUN
aisthesis-3151	51	72	)	)	PUNCT
aisthesis-3151	51	73	u	u	PROPN
aisthesis-3151	51	74	/	/	SYM
aisthesis-3151	51	75	m2	m2	PROPN
aisthesis-3151	51	76	in	in	ADP
aisthesis-3151	51	77	the	the	DET
aisthesis-3151	51	78	combination	combination	NOUN
aisthesis-3151	51	79	arm	arm	NOUN
aisthesis-3151	51	80	,	,	PUNCT
aisthesis-3151	51	81	and	and	CCONJ
aisthesis-3151	51	82	hd	hd	NOUN
aisthesis-3151	51	83	-	-	NOUN
aisthesis-3151	51	84	il2	il2	NOUN
aisthesis-3151	51	85	was	be	AUX
aisthesis-3151	51	86	given	give	VERB
aisthesis-3151	51	87	at	at	ADP
aisthesis-3151	51	88	a	a	DET
aisthesis-3151	51	89	dosage	dosage	NOUN
aisthesis-3151	51	90	of	of	ADP
aisthesis-3151	51	91	1.33	1.33	NUM
aisthesis-3151	51	92	mg	mg	NOUN
aisthesis-3151	51	93	/	/	SYM
aisthesis-3151	51	94	m2	m2	PROPN
aisthesis-3151	51	95	when	when	SCONJ
aisthesis-3151	51	96	given	give	VERB
aisthesis-3151	51	97	as	as	ADP
aisthesis-3151	51	98	a	a	DET
aisthesis-3151	51	99	monotherapy	monotherapy	NOUN
aisthesis-3151	51	100	.	.	PUNCT
aisthesis-3151	52	1	a	a	DET
aisthesis-3151	52	2	)	)	PUNCT
aisthesis-3151	52	3	survival	survival	NOUN
aisthesis-3151	52	4	conferred	confer	VERB
aisthesis-3151	52	5	with	with	ADP
aisthesis-3151	52	6	the	the	DET
aisthesis-3151	52	7	hd	hd	NOUN
aisthesis-3151	52	8	-	-	NOUN
aisthesis-3151	52	9	il2	il2	NOUN
aisthesis-3151	52	10	/	/	SYM
aisthesis-3151	52	11	ifn-	ifn-	NOUN
aisthesis-3151	52	12	'	'	PUNCT
aisthesis-3151	52	13	combination	combination	NOUN
aisthesis-3151	52	14	treatment	treatment	NOUN
aisthesis-3151	52	15	.	.	PUNCT
aisthesis-3151	53	1	mortality	mortality	NOUN
aisthesis-3151	53	2	rate	rate	NOUN
aisthesis-3151	53	3	at	at	ADP
aisthesis-3151	53	4	24	24	NUM
aisthesis-3151	53	5	months	month	NOUN
aisthesis-3151	53	6	is	be	AUX
aisthesis-3151	53	7	approximately	approximately	ADV
aisthesis-3151	53	8	70	70	NUM
aisthesis-3151	53	9	%	%	NOUN
aisthesis-3151	53	10	.	.	PUNCT
aisthesis-3151	54	1	b	b	X
aisthesis-3151	54	2	)	)	PUNCT
aisthesis-3151	54	3	survival	survival	NOUN
aisthesis-3151	54	4	conferred	confer	VERB
aisthesis-3151	54	5	with	with	ADP
aisthesis-3151	54	6	the	the	DET
aisthesis-3151	54	7	hd	hd	NOUN
aisthesis-3151	54	8	-	-	ADJ
aisthesis-3151	54	9	il2	il2	ADJ
aisthesis-3151	54	10	single	single	ADJ
aisthesis-3151	54	11	treatment	treatment	NOUN
aisthesis-3151	54	12	.	.	PUNCT
aisthesis-3151	55	1	mortality	mortality	NOUN
aisthesis-3151	55	2	rate	rate	NOUN
aisthesis-3151	55	3	at	at	ADP
aisthesis-3151	55	4	24	24	NUM
aisthesis-3151	55	5	months	month	NOUN
aisthesis-3151	55	6	is	be	AUX
aisthesis-3151	55	7	approximately	approximately	ADV
aisthesis-3151	55	8	70	70	NUM
aisthesis-3151	55	9	%	%	NOUN
aisthesis-3151	55	10	.	.	PUNCT
aisthesis-3151	56	1	(	(	PUNCT
aisthesis-3151	56	2	figure	figure	NOUN
aisthesis-3151	56	3	adapted	adapt	VERB
aisthesis-3151	56	4	from	from	ADP
aisthesis-3151	56	5	atkins	atkins	PROPN
aisthesis-3151	56	6	et	et	PROPN
aisthesis-3151	56	7	al	al	PROPN
aisthesis-3151	56	8	.	.	PROPN
aisthesis-3151	56	9	,	,	PUNCT
aisthesis-3151	56	10	1993	1993	NUM
aisthesis-3151	56	11	.	.	PUNCT
aisthesis-3151	56	12	)	)	PUNCT
aisthesis-3151	56	13	!	!	PUNCT
aisthesis-3151	57	1	e	e	X
aisthesis-3151	57	2	past	past	NOUN
aisthesis-3151	57	3	,	,	PUNCT
aisthesis-3151	57	4	present	present	ADJ
aisthesis-3151	57	5	,	,	PUNCT
aisthesis-3151	57	6	and	and	CCONJ
aisthesis-3151	57	7	future	future	NOUN
aisthesis-3151	57	8	of	of	ADP
aisthesis-3151	57	9	renal	renal	ADJ
aisthesis-3151	57	10	cell	cell	NOUN
aisthesis-3151	57	11	carcinoma	carcinoma	NOUN
aisthesis-3151	57	12	treatment	treatment	NOUN
aisthesis-3151	57	13	aisthesis	aisthesis	NOUN
aisthesis-3151	57	14	volume	volume	NOUN
aisthesis-3151	57	15	11	11	NUM
aisthesis-3151	57	16	,	,	PUNCT
aisthesis-3151	57	17	20203	20203	NUM
aisthesis-3151	57	18	hd	hd	NOUN
aisthesis-3151	57	19	-	-	ADJ
aisthesis-3151	57	20	il2	il2	NOUN
aisthesis-3151	57	21	therapy	therapy	NOUN
aisthesis-3151	57	22	,	,	PUNCT
aisthesis-3151	57	23	in	in	ADP
aisthesis-3151	57	24	comparison	comparison	NOUN
aisthesis-3151	57	25	with	with	ADP
aisthesis-3151	57	26	other	other	ADJ
aisthesis-3151	57	27	cytokine	cytokine	NOUN
aisthesis-3151	57	28	immunotherapies	immunotherapy	NOUN
aisthesis-3151	57	29	,	,	PUNCT
aisthesis-3151	57	30	were	be	AUX
aisthesis-3151	57	31	observed	observe	VERB
aisthesis-3151	57	32	in	in	ADP
aisthesis-3151	57	33	additional	additional	ADJ
aisthesis-3151	57	34	phase	phase	NOUN
aisthesis-3151	57	35	ii	ii	NOUN
aisthesis-3151	57	36	trials	trial	NOUN
aisthesis-3151	57	37	(	(	PUNCT
aisthesis-3151	57	38	fyfe	fyfe	ADP
aisthesis-3151	57	39	et	et	PROPN
aisthesis-3151	57	40	al	al	PROPN
aisthesis-3151	57	41	.	.	PROPN
aisthesis-3151	57	42	,	,	PUNCT
aisthesis-3151	57	43	1995	1995	NUM
aisthesis-3151	57	44	)	)	PUNCT
aisthesis-3151	57	45	.	.	PUNCT
aisthesis-3151	58	1	in	in	ADP
aisthesis-3151	58	2	the	the	DET
aisthesis-3151	58	3	broader	broad	ADJ
aisthesis-3151	58	4	context	context	NOUN
aisthesis-3151	58	5	of	of	ADP
aisthesis-3151	58	6	renal	renal	ADJ
aisthesis-3151	58	7	cell	cell	NOUN
aisthesis-3151	58	8	carcinoma	carcinoma	NOUN
aisthesis-3151	58	9	treatment	treatment	NOUN
aisthesis-3151	58	10	,	,	PUNCT
aisthesis-3151	58	11	this	this	DET
aisthesis-3151	58	12	phase	phase	NOUN
aisthesis-3151	58	13	ii	ii	NOUN
aisthesis-3151	58	14	trial	trial	NOUN
aisthesis-3151	58	15	led	lead	VERB
aisthesis-3151	58	16	by	by	ADP
aisthesis-3151	58	17	atkins	atkins	PROPN
aisthesis-3151	58	18	et	et	PROPN
aisthesis-3151	58	19	al	al	PROPN
aisthesis-3151	58	20	.	.	PROPN
aisthesis-3151	58	21	showed	show	VERB
aisthesis-3151	58	22	that	that	SCONJ
aisthesis-3151	58	23	cytokine	cytokine	NOUN
aisthesis-3151	58	24	immunotherapies	immunotherapy	NOUN
aisthesis-3151	58	25	confer	confer	VERB
aisthesis-3151	58	26	a	a	DET
aisthesis-3151	58	27	survival	survival	NOUN
aisthesis-3151	58	28	bene$t	bene$t	NOUN
aisthesis-3151	58	29	to	to	PART
aisthesis-3151	58	30	metastatic	metastatic	VERB
aisthesis-3151	58	31	renal	renal	ADJ
aisthesis-3151	58	32	cell	cell	NOUN
aisthesis-3151	58	33	carcinoma	carcinoma	NOUN
aisthesis-3151	58	34	patients	patient	NOUN
aisthesis-3151	58	35	.	.	PUNCT
aisthesis-3151	59	1	unlike	unlike	ADP
aisthesis-3151	59	2	the	the	DET
aisthesis-3151	59	3	$	$	SYM
aisthesis-3151	59	4	ndings	nding	NOUN
aisthesis-3151	59	5	in	in	ADP
aisthesis-3151	59	6	murine	murine	ADJ
aisthesis-3151	59	7	models	model	NOUN
aisthesis-3151	59	8	,	,	PUNCT
aisthesis-3151	59	9	therapy	therapy	NOUN
aisthesis-3151	59	10	with	with	ADP
aisthesis-3151	59	11	hd	hd	NOUN
aisthesis-3151	59	12	-	-	NOUN
aisthesis-3151	59	13	il2	il2	NOUN
aisthesis-3151	59	14	alone	alone	ADV
aisthesis-3151	59	15	was	be	AUX
aisthesis-3151	59	16	found	find	VERB
aisthesis-3151	59	17	to	to	PART
aisthesis-3151	59	18	produce	produce	VERB
aisthesis-3151	59	19	meaningful	meaningful	ADJ
aisthesis-3151	59	20	and	and	CCONJ
aisthesis-3151	59	21	durable	durable	ADJ
aisthesis-3151	59	22	responses	response	NOUN
aisthesis-3151	59	23	with	with	ADP
aisthesis-3151	59	24	manageable	manageable	ADJ
aisthesis-3151	59	25	and	and	CCONJ
aisthesis-3151	59	26	reversible	reversible	ADJ
aisthesis-3151	59	27	toxicity	toxicity	NOUN
aisthesis-3151	59	28	in	in	ADP
aisthesis-3151	59	29	renal	renal	ADJ
aisthesis-3151	59	30	cell	cell	NOUN
aisthesis-3151	59	31	carcinoma	carcinoma	NOUN
aisthesis-3151	59	32	patients	patient	NOUN
aisthesis-3151	59	33	.	.	PUNCT
aisthesis-3151	60	1	a	a	DET
aisthesis-3151	60	2	possible	possible	ADJ
aisthesis-3151	60	3	reason	reason	NOUN
aisthesis-3151	60	4	for	for	ADP
aisthesis-3151	60	5	the	the	DET
aisthesis-3151	60	6	di!erences	di!erence	NOUN
aisthesis-3151	60	7	in	in	ADP
aisthesis-3151	60	8	outcomes	outcome	NOUN
aisthesis-3151	60	9	of	of	ADP
aisthesis-3151	60	10	the	the	DET
aisthesis-3151	60	11	two	two	NUM
aisthesis-3151	60	12	arms	arm	NOUN
aisthesis-3151	60	13	is	be	AUX
aisthesis-3151	60	14	that	that	SCONJ
aisthesis-3151	60	15	the	the	DET
aisthesis-3151	60	16	hd	hd	NOUN
aisthesis-3151	60	17	-	-	NOUN
aisthesis-3151	60	18	il2	il2	NOUN
aisthesis-3151	60	19	/	/	SYM
aisthesis-3151	60	20	ifn-	ifn-	NOUN
aisthesis-3151	60	21	'	'	PUNCT
aisthesis-3151	60	22	arm	arm	NOUN
aisthesis-3151	60	23	may	may	AUX
aisthesis-3151	60	24	have	have	VERB
aisthesis-3151	60	25	over	over	ADV
aisthesis-3151	60	26	-	-	PUNCT
aisthesis-3151	60	27	activated	activate	VERB
aisthesis-3151	60	28	the	the	DET
aisthesis-3151	60	29	immune	immune	ADJ
aisthesis-3151	60	30	system	system	NOUN
aisthesis-3151	60	31	.	.	PUNCT
aisthesis-3151	61	1	an	an	DET
aisthesis-3151	61	2	excessive	excessive	ADJ
aisthesis-3151	61	3	number	number	NOUN
aisthesis-3151	61	4	of	of	ADP
aisthesis-3151	61	5	activated	activated	ADJ
aisthesis-3151	61	6	immune	immune	ADJ
aisthesis-3151	61	7	cells	cell	NOUN
aisthesis-3151	61	8	(	(	PUNCT
aisthesis-3151	61	9	such	such	ADJ
aisthesis-3151	61	10	as	as	ADP
aisthesis-3151	61	11	b	b	PROPN
aisthesis-3151	61	12	cells	cell	NOUN
aisthesis-3151	61	13	,	,	PUNCT
aisthesis-3151	61	14	t	t	NOUN
aisthesis-3151	61	15	cells	cell	NOUN
aisthesis-3151	61	16	,	,	PUNCT
aisthesis-3151	61	17	and	and	CCONJ
aisthesis-3151	61	18	macrophages	macrophage	NOUN
aisthesis-3151	61	19	)	)	PUNCT
aisthesis-3151	61	20	may	may	AUX
aisthesis-3151	61	21	lead	lead	VERB
aisthesis-3151	61	22	to	to	ADP
aisthesis-3151	61	23	scenarios	scenario	NOUN
aisthesis-3151	61	24	of	of	ADP
aisthesis-3151	61	25	autoimmunity	autoimmunity	NOUN
aisthesis-3151	61	26	,	,	PUNCT
aisthesis-3151	61	27	in	in	ADP
aisthesis-3151	61	28	which	which	PRON
aisthesis-3151	61	29	the	the	DET
aisthesis-3151	61	30	immune	immune	ADJ
aisthesis-3151	61	31	system	system	NOUN
aisthesis-3151	61	32	erroneously	erroneously	ADV
aisthesis-3151	61	33	identi$es	identi$es	PRON
aisthesis-3151	61	34	normal	normal	ADJ
aisthesis-3151	61	35	cells	cell	NOUN
aisthesis-3151	61	36	in	in	ADP
aisthesis-3151	61	37	organs	organ	NOUN
aisthesis-3151	61	38	as	as	ADP
aisthesis-3151	61	39	dangerous	dangerous	ADJ
aisthesis-3151	61	40	,	,	PUNCT
aisthesis-3151	61	41	and	and	CCONJ
aisthesis-3151	61	42	subsequently	subsequently	ADV
aisthesis-3151	61	43	attacks	attack	VERB
aisthesis-3151	61	44	them	they	PRON
aisthesis-3151	61	45	.	.	PUNCT
aisthesis-3151	62	1	although	although	SCONJ
aisthesis-3151	62	2	cytokine	cytokine	ADJ
aisthesis-3151	62	3	immunotherapy	immunotherapy	NOUN
aisthesis-3151	62	4	was	be	AUX
aisthesis-3151	62	5	approved	approve	VERB
aisthesis-3151	62	6	by	by	ADP
aisthesis-3151	62	7	the	the	DET
aisthesis-3151	62	8	fda	fda	PROPN
aisthesis-3151	62	9	for	for	ADP
aisthesis-3151	62	10	treatment	treatment	NOUN
aisthesis-3151	62	11	of	of	ADP
aisthesis-3151	62	12	renal	renal	ADJ
aisthesis-3151	62	13	cell	cell	NOUN
aisthesis-3151	62	14	carcinoma	carcinoma	NOUN
aisthesis-3151	62	15	in	in	ADP
aisthesis-3151	62	16	1992	1992	NUM
aisthesis-3151	62	17	,	,	PUNCT
aisthesis-3151	62	18	the	the	DET
aisthesis-3151	62	19	need	need	NOUN
aisthesis-3151	62	20	for	for	ADP
aisthesis-3151	62	21	more	more	ADJ
aisthesis-3151	62	22	speci$c	speci$c	NOUN
aisthesis-3151	62	23	,	,	PUNCT
aisthesis-3151	62	24	targeted	target	VERB
aisthesis-3151	62	25	therapies	therapy	NOUN
aisthesis-3151	62	26	to	to	PART
aisthesis-3151	62	27	reduce	reduce	VERB
aisthesis-3151	62	28	toxicities	toxicity	NOUN
aisthesis-3151	62	29	and	and	CCONJ
aisthesis-3151	62	30	further	far	ADV
aisthesis-3151	62	31	improve	improve	VERB
aisthesis-3151	62	32	survival	survival	NOUN
aisthesis-3151	62	33	was	be	AUX
aisthesis-3151	62	34	established	establish	VERB
aisthesis-3151	62	35	.	.	PUNCT
aisthesis-3151	63	1	2003	2003	NUM
aisthesis-3151	63	2	-	-	PUNCT
aisthesis-3151	63	3	present	present	ADJ
aisthesis-3151	63	4	:	:	PUNCT
aisthesis-3151	63	5	sunitinib	sunitinib	NOUN
aisthesis-3151	63	6	and	and	CCONJ
aisthesis-3151	63	7	other	other	ADJ
aisthesis-3151	63	8	targeted	target	VERB
aisthesis-3151	63	9	,	,	PUNCT
aisthesis-3151	63	10	pathway	pathway	NOUN
aisthesis-3151	63	11	-	-	PUNCT
aisthesis-3151	63	12	speci#c	speci#c	NOUN
aisthesis-3151	63	13	vegf	vegf	PROPN
aisthesis-3151	63	14	-	-	PUNCT
aisthesis-3151	63	15	tki	tki	PROPN
aisthesis-3151	63	16	!	!	PUNCT
aisthesis-3151	63	17	erapies	erapie	NOUN
aisthesis-3151	63	18	while	while	SCONJ
aisthesis-3151	63	19	the	the	DET
aisthesis-3151	63	20	pathogenesis	pathogenesis	NOUN
aisthesis-3151	63	21	of	of	ADP
aisthesis-3151	63	22	kidney	kidney	NOUN
aisthesis-3151	63	23	cancer	cancer	NOUN
aisthesis-3151	63	24	is	be	AUX
aisthesis-3151	63	25	quite	quite	ADV
aisthesis-3151	63	26	complex	complex	ADJ
aisthesis-3151	63	27	,	,	PUNCT
aisthesis-3151	63	28	mutations	mutation	NOUN
aisthesis-3151	63	29	in	in	ADP
aisthesis-3151	63	30	the	the	DET
aisthesis-3151	63	31	vhl	vhl	PROPN
aisthesis-3151	63	32	gene	gene	NOUN
aisthesis-3151	63	33	are	be	AUX
aisthesis-3151	63	34	known	know	VERB
aisthesis-3151	63	35	to	to	PART
aisthesis-3151	63	36	play	play	VERB
aisthesis-3151	63	37	a	a	DET
aisthesis-3151	63	38	role	role	NOUN
aisthesis-3151	63	39	in	in	ADP
aisthesis-3151	63	40	cellular	cellular	ADJ
aisthesis-3151	63	41	physiology	physiology	NOUN
aisthesis-3151	63	42	by	by	ADP
aisthesis-3151	63	43	upregulating	upregulate	VERB
aisthesis-3151	63	44	the	the	DET
aisthesis-3151	63	45	expression	expression	NOUN
aisthesis-3151	63	46	of	of	ADP
aisthesis-3151	63	47	the	the	DET
aisthesis-3151	63	48	vascular	vascular	ADJ
aisthesis-3151	63	49	endothelial	endothelial	ADJ
aisthesis-3151	63	50	growth	growth	NOUN
aisthesis-3151	63	51	factor	factor	NOUN
aisthesis-3151	63	52	(	(	PUNCT
aisthesis-3151	63	53	vegf	vegf	PROPN
aisthesis-3151	63	54	)	)	PUNCT
aisthesis-3151	63	55	gene	gene	NOUN
aisthesis-3151	63	56	.	.	PUNCT
aisthesis-3151	64	1	#	#	X
aisthesis-3151	64	2	e	e	NOUN
aisthesis-3151	64	3	protein	protein	NOUN
aisthesis-3151	64	4	encoded	encode	VERB
aisthesis-3151	64	5	by	by	ADP
aisthesis-3151	64	6	vegf	vegf	PROPN
aisthesis-3151	64	7	plays	play	VERB
aisthesis-3151	64	8	a	a	DET
aisthesis-3151	64	9	critical	critical	ADJ
aisthesis-3151	64	10	role	role	NOUN
aisthesis-3151	64	11	in	in	ADP
aisthesis-3151	64	12	forming	form	VERB
aisthesis-3151	64	13	blood	blood	NOUN
aisthesis-3151	64	14	vessels	vessel	NOUN
aisthesis-3151	64	15	that	that	PRON
aisthesis-3151	64	16	carry	carry	VERB
aisthesis-3151	64	17	nutrient	nutrient	NOUN
aisthesis-3151	64	18	-	-	PUNCT
aisthesis-3151	64	19	rich	rich	ADJ
aisthesis-3151	64	20	blood	blood	NOUN
aisthesis-3151	64	21	to	to	ADP
aisthesis-3151	64	22	the	the	DET
aisthesis-3151	64	23	site	site	NOUN
aisthesis-3151	64	24	of	of	ADP
aisthesis-3151	64	25	the	the	DET
aisthesis-3151	64	26	tumor	tumor	NOUN
aisthesis-3151	64	27	.	.	PUNCT
aisthesis-3151	65	1	ultimately	ultimately	ADV
aisthesis-3151	65	2	,	,	PUNCT
aisthesis-3151	65	3	this	this	PRON
aisthesis-3151	65	4	leads	lead	VERB
aisthesis-3151	65	5	to	to	ADP
aisthesis-3151	65	6	tumor	tumor	NOUN
aisthesis-3151	65	7	growth	growth	NOUN
aisthesis-3151	65	8	and	and	CCONJ
aisthesis-3151	65	9	provides	provide	VERB
aisthesis-3151	65	10	an	an	DET
aisthesis-3151	65	11	escape	escape	NOUN
aisthesis-3151	65	12	path	path	NOUN
aisthesis-3151	65	13	for	for	ADP
aisthesis-3151	65	14	malignant	malignant	ADJ
aisthesis-3151	65	15	cells	cell	NOUN
aisthesis-3151	65	16	,	,	PUNCT
aisthesis-3151	65	17	which	which	PRON
aisthesis-3151	65	18	increases	increase	VERB
aisthesis-3151	65	19	the	the	DET
aisthesis-3151	65	20	probability	probability	NOUN
aisthesis-3151	65	21	of	of	ADP
aisthesis-3151	65	22	metastasis	metastasis	NOUN
aisthesis-3151	65	23	.	.	PUNCT
aisthesis-3151	66	1	#	#	X
aisthesis-3151	66	2	e	e	NOUN
aisthesis-3151	66	3	angiogenesis	angiogenesis	NOUN
aisthesis-3151	66	4	pathway	pathway	NOUN
aisthesis-3151	66	5	is	be	AUX
aisthesis-3151	66	6	initiated	initiate	VERB
aisthesis-3151	66	7	by	by	ADP
aisthesis-3151	66	8	the	the	DET
aisthesis-3151	66	9	binding	binding	NOUN
aisthesis-3151	66	10	of	of	ADP
aisthesis-3151	66	11	vegf	vegf	PROPN
aisthesis-3151	66	12	to	to	ADP
aisthesis-3151	66	13	the	the	DET
aisthesis-3151	66	14	vegf	vegf	PROPN
aisthesis-3151	66	15	receptor	receptor	NOUN
aisthesis-3151	66	16	(	(	PUNCT
aisthesis-3151	66	17	vegfr	vegfr	NOUN
aisthesis-3151	66	18	)	)	PUNCT
aisthesis-3151	66	19	,	,	PUNCT
aisthesis-3151	66	20	which	which	PRON
aisthesis-3151	66	21	conducts	conduct	VERB
aisthesis-3151	66	22	the	the	DET
aisthesis-3151	66	23	signal	signal	NOUN
aisthesis-3151	66	24	via	via	ADP
aisthesis-3151	66	25	tyrosine	tyrosine	NOUN
aisthesis-3151	66	26	-	-	PUNCT
aisthesis-3151	66	27	kinase	kinase	NOUN
aisthesis-3151	66	28	activity	activity	NOUN
aisthesis-3151	66	29	.	.	PUNCT
aisthesis-3151	67	1	in	in	ADP
aisthesis-3151	67	2	all	all	PRON
aisthesis-3151	67	3	,	,	PUNCT
aisthesis-3151	67	4	there	there	PRON
aisthesis-3151	67	5	are	be	VERB
aisthesis-3151	67	6	three	three	NUM
aisthesis-3151	67	7	vegfr	vegfr	NOUN
aisthesis-3151	67	8	to	to	ADP
aisthesis-3151	67	9	which	which	PRON
aisthesis-3151	67	10	the	the	DET
aisthesis-3151	67	11	vegf	vegf	PROPN
aisthesis-3151	67	12	ligand	ligand	PROPN
aisthesis-3151	67	13	can	can	AUX
aisthesis-3151	67	14	bind	bind	VERB
aisthesis-3151	67	15	:	:	PUNCT
aisthesis-3151	67	16	vegfr-1	vegfr-1	NUM
aisthesis-3151	67	17	,	,	PUNCT
aisthesis-3151	67	18	vegfr-2	vegfr-2	NUM
aisthesis-3151	67	19	,	,	PUNCT
aisthesis-3151	67	20	and	and	CCONJ
aisthesis-3151	67	21	vegfr-3	vegfr-3	NUM
aisthesis-3151	67	22	.	.	PUNCT
aisthesis-3151	68	1	ligand	ligand	NOUN
aisthesis-3151	68	2	-	-	PUNCT
aisthesis-3151	68	3	receptor	receptor	NOUN
aisthesis-3151	68	4	binding	binding	NOUN
aisthesis-3151	68	5	can	can	AUX
aisthesis-3151	68	6	result	result	VERB
aisthesis-3151	68	7	in	in	ADP
aisthesis-3151	68	8	one	one	NUM
aisthesis-3151	68	9	or	or	CCONJ
aisthesis-3151	68	10	more	more	ADJ
aisthesis-3151	68	11	of	of	ADP
aisthesis-3151	68	12	three	three	NUM
aisthesis-3151	68	13	critical	critical	ADJ
aisthesis-3151	68	14	outcomes	outcome	NOUN
aisthesis-3151	68	15	that	that	PRON
aisthesis-3151	68	16	yield	yield	VERB
aisthesis-3151	68	17	angiogenesis	angiogenesis	NOUN
aisthesis-3151	68	18	:	:	PUNCT
aisthesis-3151	68	19	endothelial	endothelial	ADJ
aisthesis-3151	68	20	cell	cell	NOUN
aisthesis-3151	68	21	migration	migration	NOUN
aisthesis-3151	68	22	(	(	PUNCT
aisthesis-3151	68	23	the	the	DET
aisthesis-3151	68	24	lining	lining	NOUN
aisthesis-3151	68	25	up	up	ADP
aisthesis-3151	68	26	of	of	ADP
aisthesis-3151	68	27	endothelial	endothelial	ADJ
aisthesis-3151	68	28	cells	cell	NOUN
aisthesis-3151	68	29	to	to	PART
aisthesis-3151	68	30	form	form	VERB
aisthesis-3151	68	31	a	a	DET
aisthesis-3151	68	32	blood	blood	NOUN
aisthesis-3151	68	33	vessel	vessel	NOUN
aisthesis-3151	68	34	)	)	PUNCT
aisthesis-3151	68	35	,	,	PUNCT
aisthesis-3151	68	36	a	a	DET
aisthesis-3151	68	37	change	change	NOUN
aisthesis-3151	68	38	in	in	ADP
aisthesis-3151	68	39	vascular	vascular	ADJ
aisthesis-3151	68	40	permeability	permeability	NOUN
aisthesis-3151	68	41	(	(	PUNCT
aisthesis-3151	68	42	the	the	DET
aisthesis-3151	68	43	capacity	capacity	NOUN
aisthesis-3151	68	44	of	of	ADP
aisthesis-3151	68	45	blood	blood	NOUN
aisthesis-3151	68	46	vessel	vessel	NOUN
aisthesis-3151	68	47	to	to	PART
aisthesis-3151	68	48	allow	allow	VERB
aisthesis-3151	68	49	entry	entry	NOUN
aisthesis-3151	68	50	of	of	ADP
aisthesis-3151	68	51	nutrients	nutrient	NOUN
aisthesis-3151	68	52	to	to	PART
aisthesis-3151	68	53	enrich	enrich	VERB
aisthesis-3151	68	54	the	the	DET
aisthesis-3151	68	55	blood	blood	NOUN
aisthesis-3151	68	56	)	)	PUNCT
aisthesis-3151	68	57	,	,	PUNCT
aisthesis-3151	68	58	and	and	CCONJ
aisthesis-3151	68	59	endothelial	endothelial	ADJ
aisthesis-3151	68	60	cell	cell	NOUN
aisthesis-3151	68	61	proliferation	proliferation	NOUN
aisthesis-3151	68	62	(	(	PUNCT
aisthesis-3151	68	63	the	the	DET
aisthesis-3151	68	64	replication	replication	NOUN
aisthesis-3151	68	65	of	of	ADP
aisthesis-3151	68	66	endothelial	endothelial	ADJ
aisthesis-3151	68	67	cells	cell	NOUN
aisthesis-3151	68	68	that	that	PRON
aisthesis-3151	68	69	will	will	AUX
aisthesis-3151	68	70	ultimately	ultimately	ADV
aisthesis-3151	68	71	line	line	VERB
aisthesis-3151	68	72	the	the	DET
aisthesis-3151	68	73	blood	blood	NOUN
aisthesis-3151	68	74	vessel	vessel	NOUN
aisthesis-3151	68	75	)	)	PUNCT
aisthesis-3151	68	76	(	(	PUNCT
aisthesis-3151	68	77	morabito	morabito	PROPN
aisthesis-3151	68	78	et	et	PROPN
aisthesis-3151	68	79	al	al	PROPN
aisthesis-3151	68	80	.	.	PROPN
aisthesis-3151	68	81	2006	2006	NUM
aisthesis-3151	68	82	)	)	PUNCT
aisthesis-3151	68	83	.	.	PUNCT
aisthesis-3151	69	1	upon	upon	SCONJ
aisthesis-3151	69	2	discovery	discovery	NOUN
aisthesis-3151	69	3	of	of	ADP
aisthesis-3151	69	4	vhl	vhl	PROPN
aisthesis-3151	69	5	mutations	mutation	NOUN
aisthesis-3151	69	6	and	and	CCONJ
aisthesis-3151	69	7	their	their	PRON
aisthesis-3151	69	8	consequences	consequence	NOUN
aisthesis-3151	69	9	for	for	ADP
aisthesis-3151	69	10	the	the	DET
aisthesis-3151	69	11	angiogenesis	angiogenesis	NOUN
aisthesis-3151	69	12	pathway	pathway	NOUN
aisthesis-3151	69	13	,	,	PUNCT
aisthesis-3151	69	14	the	the	DET
aisthesis-3151	69	15	novel	novel	ADJ
aisthesis-3151	69	16	idea	idea	NOUN
aisthesis-3151	69	17	of	of	ADP
aisthesis-3151	69	18	targeting	target	VERB
aisthesis-3151	69	19	such	such	DET
aisthesis-3151	69	20	a	a	DET
aisthesis-3151	69	21	speci$c	speci$c	ADJ
aisthesis-3151	69	22	cellular	cellular	ADJ
aisthesis-3151	69	23	pathway	pathway	NOUN
aisthesis-3151	69	24	with	with	ADP
aisthesis-3151	69	25	synthetic	synthetic	ADJ
aisthesis-3151	69	26	chemicals	chemical	NOUN
aisthesis-3151	69	27	in	in	ADP
aisthesis-3151	69	28	hopes	hope	NOUN
aisthesis-3151	69	29	of	of	ADP
aisthesis-3151	69	30	mitigating	mitigate	VERB
aisthesis-3151	69	31	cancer	cancer	NOUN
aisthesis-3151	69	32	growth	growth	NOUN
aisthesis-3151	69	33	became	become	VERB
aisthesis-3151	69	34	popular	popular	ADJ
aisthesis-3151	69	35	.	.	PUNCT
aisthesis-3151	70	1	blocking	block	VERB
aisthesis-3151	70	2	angiogenesis	angiogenesis	NOUN
aisthesis-3151	70	3	with	with	ADP
aisthesis-3151	70	4	inhibitory	inhibitory	ADJ
aisthesis-3151	70	5	pharmacological	pharmacological	ADJ
aisthesis-3151	70	6	agents	agent	NOUN
aisthesis-3151	70	7	(	(	PUNCT
aisthesis-3151	70	8	known	know	VERB
aisthesis-3151	70	9	as	as	ADP
aisthesis-3151	70	10	vegf	vegf	PROPN
aisthesis-3151	70	11	-	-	PUNCT
aisthesis-3151	70	12	tyrosine	tyrosine	PROPN
aisthesis-3151	70	13	kinase	kinase	PROPN
aisthesis-3151	70	14	inhibitors	inhibitor	NOUN
aisthesis-3151	70	15	,	,	PUNCT
aisthesis-3151	70	16	vegf	vegf	PROPN
aisthesis-3151	70	17	-	-	PUNCT
aisthesis-3151	70	18	tkis	tkis	PROPN
aisthesis-3151	70	19	)	)	PUNCT
aisthesis-3151	70	20	revolutionized	revolutionize	VERB
aisthesis-3151	70	21	the	the	DET
aisthesis-3151	70	22	figure	figure	NOUN
aisthesis-3151	70	23	3	3	NUM
aisthesis-3151	70	24	:	:	PUNCT
aisthesis-3151	70	25	targets	target	NOUN
aisthesis-3151	70	26	of	of	ADP
aisthesis-3151	70	27	di"erent	di"erent	PROPN
aisthesis-3151	70	28	vegf	vegf	PROPN
aisthesis-3151	70	29	-	-	PUNCT
aisthesis-3151	70	30	tki	tki	PROPN
aisthesis-3151	70	31	therapies	therapy	NOUN
aisthesis-3151	70	32	.	.	PUNCT
aisthesis-3151	71	1	although	although	SCONJ
aisthesis-3151	71	2	vegf	vegf	PROPN
aisthesis-3151	71	3	-	-	PUNCT
aisthesis-3151	71	4	tkis	tkis	PROPN
aisthesis-3151	71	5	achieve	achieve	VERB
aisthesis-3151	71	6	the	the	DET
aisthesis-3151	71	7	same	same	ADJ
aisthesis-3151	71	8	result	result	NOUN
aisthesis-3151	71	9	of	of	ADP
aisthesis-3151	71	10	preventing	prevent	VERB
aisthesis-3151	71	11	angiogenesis	angiogenesis	NOUN
aisthesis-3151	71	12	,	,	PUNCT
aisthesis-3151	71	13	each	each	DET
aisthesis-3151	71	14	drug	drug	NOUN
aisthesis-3151	71	15	has	have	VERB
aisthesis-3151	71	16	a	a	DET
aisthesis-3151	71	17	di!erent	di!erent	NOUN
aisthesis-3151	71	18	speci$city	speci$city	NOUN
aisthesis-3151	71	19	.	.	PUNCT
aisthesis-3151	72	1	of	of	ADP
aisthesis-3151	72	2	the	the	DET
aisthesis-3151	72	3	diverse	diverse	ADJ
aisthesis-3151	72	4	tkis	tkis	NOUN
aisthesis-3151	72	5	shown	show	VERB
aisthesis-3151	72	6	above	above	ADP
aisthesis-3151	72	7	,	,	PUNCT
aisthesis-3151	72	8	sunitinib	sunitinib	NOUN
aisthesis-3151	72	9	,	,	PUNCT
aisthesis-3151	72	10	axitinib	axitinib	NOUN
aisthesis-3151	72	11	,	,	PUNCT
aisthesis-3151	72	12	and	and	CCONJ
aisthesis-3151	72	13	sorafenib	sorafenib	NOUN
aisthesis-3151	72	14	are	be	AUX
aisthesis-3151	72	15	more	more	ADV
aisthesis-3151	72	16	widely	widely	ADV
aisthesis-3151	72	17	utilized	utilize	VERB
aisthesis-3151	72	18	in	in	ADP
aisthesis-3151	72	19	treatment	treatment	NOUN
aisthesis-3151	72	20	of	of	ADP
aisthesis-3151	72	21	renal	renal	ADJ
aisthesis-3151	72	22	cell	cell	NOUN
aisthesis-3151	72	23	carcinoma	carcinoma	NOUN
aisthesis-3151	72	24	.	.	PUNCT
aisthesis-3151	73	1	sunitinib	sunitinib	NOUN
aisthesis-3151	73	2	and	and	CCONJ
aisthesis-3151	73	3	axitinib	axitinib	NOUN
aisthesis-3151	73	4	each	each	DET
aisthesis-3151	73	5	preferentially	preferentially	ADV
aisthesis-3151	73	6	target	target	VERB
aisthesis-3151	73	7	both	both	PRON
aisthesis-3151	73	8	vegfr-1	vegfr-1	NUM
aisthesis-3151	73	9	and	and	CCONJ
aisthesis-3151	73	10	vegfr-2	vegfr-2	NUM
aisthesis-3151	73	11	,	,	PUNCT
aisthesis-3151	73	12	and	and	CCONJ
aisthesis-3151	73	13	sorafenib	sorafenib	NOUN
aisthesis-3151	73	14	targets	target	NOUN
aisthesis-3151	73	15	vegfr-2	vegfr-2	NUM
aisthesis-3151	73	16	and	and	CCONJ
aisthesis-3151	73	17	mek	mek	PROPN
aisthesis-3151	73	18	.	.	PUNCT
aisthesis-3151	74	1	figure	figure	VERB
aisthesis-3151	74	2	modi$ed	modi$ed	PROPN
aisthesis-3151	74	3	from	from	ADP
aisthesis-3151	74	4	morabito	morabito	PROPN
aisthesis-3151	74	5	et	et	PROPN
aisthesis-3151	74	6	al	al	PROPN
aisthesis-3151	74	7	.	.	PROPN
aisthesis-3151	74	8	,	,	PUNCT
aisthesis-3151	74	9	2006	2006	NUM
aisthesis-3151	74	10	.	.	PUNCT
aisthesis-3151	75	1	figure	figure	VERB
aisthesis-3151	75	2	4	4	NUM
aisthesis-3151	75	3	:	:	PUNCT
aisthesis-3151	75	4	progression	progression	NOUN
aisthesis-3151	75	5	-	-	PUNCT
aisthesis-3151	75	6	free	free	ADJ
aisthesis-3151	75	7	survival	survival	NOUN
aisthesis-3151	75	8	(	(	PUNCT
aisthesis-3151	75	9	pfs	pfs	PROPN
aisthesis-3151	75	10	)	)	PUNCT
aisthesis-3151	75	11	is	be	AUX
aisthesis-3151	75	12	greater	great	ADJ
aisthesis-3151	75	13	in	in	ADP
aisthesis-3151	75	14	patients	patient	NOUN
aisthesis-3151	75	15	treated	treat	VERB
aisthesis-3151	75	16	with	with	ADP
aisthesis-3151	75	17	sunitinib	sunitinib	NOUN
aisthesis-3151	75	18	than	than	ADP
aisthesis-3151	75	19	ifn-$.	ifn-$.	PROPN
aisthesis-3151	75	20	a	a	DET
aisthesis-3151	75	21	total	total	NOUN
aisthesis-3151	75	22	of	of	ADP
aisthesis-3151	75	23	750	750	NUM
aisthesis-3151	75	24	patients	patient	NOUN
aisthesis-3151	75	25	were	be	AUX
aisthesis-3151	75	26	randomized	randomize	VERB
aisthesis-3151	75	27	in	in	ADP
aisthesis-3151	75	28	a	a	DET
aisthesis-3151	75	29	1:1	1:1	NUM
aisthesis-3151	75	30	ratio	ratio	NOUN
aisthesis-3151	75	31	to	to	ADP
aisthesis-3151	75	32	either	either	CCONJ
aisthesis-3151	75	33	the	the	DET
aisthesis-3151	75	34	sunitinib	sunitinib	NOUN
aisthesis-3151	75	35	treatment	treatment	NOUN
aisthesis-3151	75	36	arm	arm	NOUN
aisthesis-3151	75	37	or	or	CCONJ
aisthesis-3151	75	38	the	the	DET
aisthesis-3151	75	39	ifn-	ifn-	NOUN
aisthesis-3151	75	40	'	'	PUNCT
aisthesis-3151	75	41	arm	arm	NOUN
aisthesis-3151	75	42	.	.	PUNCT
aisthesis-3151	76	1	sunitinib	sunitinib	NOUN
aisthesis-3151	76	2	was	be	AUX
aisthesis-3151	76	3	administered	administer	VERB
aisthesis-3151	76	4	orally	orally	ADV
aisthesis-3151	76	5	at	at	ADP
aisthesis-3151	76	6	a	a	DET
aisthesis-3151	76	7	dose	dose	NOUN
aisthesis-3151	76	8	of	of	ADP
aisthesis-3151	76	9	50	50	NUM
aisthesis-3151	76	10	mg	mg	ADP
aisthesis-3151	76	11	once	once	ADV
aisthesis-3151	76	12	daily	daily	ADV
aisthesis-3151	76	13	,	,	PUNCT
aisthesis-3151	76	14	taken	take	VERB
aisthesis-3151	76	15	without	without	ADP
aisthesis-3151	76	16	regard	regard	NOUN
aisthesis-3151	76	17	to	to	ADP
aisthesis-3151	76	18	meals	meal	NOUN
aisthesis-3151	76	19	,	,	PUNCT
aisthesis-3151	76	20	in	in	ADP
aisthesis-3151	76	21	6	6	NUM
aisthesis-3151	76	22	-	-	PUNCT
aisthesis-3151	76	23	week	week	NOUN
aisthesis-3151	76	24	cycles	cycle	NOUN
aisthesis-3151	76	25	consisting	consist	VERB
aisthesis-3151	76	26	of	of	ADP
aisthesis-3151	76	27	4	4	NUM
aisthesis-3151	76	28	weeks	week	NOUN
aisthesis-3151	76	29	of	of	ADP
aisthesis-3151	76	30	treatment	treatment	NOUN
aisthesis-3151	76	31	followed	follow	VERB
aisthesis-3151	76	32	by	by	ADP
aisthesis-3151	76	33	2	2	NUM
aisthesis-3151	76	34	weeks	week	NOUN
aisthesis-3151	76	35	without	without	ADP
aisthesis-3151	76	36	treatment	treatment	NOUN
aisthesis-3151	76	37	.	.	PUNCT
aisthesis-3151	77	1	ifn-	ifn-	X
aisthesis-3151	77	2	'	'	PUNCT
aisthesis-3151	77	3	was	be	AUX
aisthesis-3151	77	4	administered	administer	VERB
aisthesis-3151	77	5	subcutaneously	subcutaneously	ADV
aisthesis-3151	77	6	three	three	NUM
aisthesis-3151	77	7	times	time	NOUN
aisthesis-3151	77	8	per	per	ADP
aisthesis-3151	77	9	week	week	NOUN
aisthesis-3151	77	10	on	on	ADP
aisthesis-3151	77	11	nonconsecutive	nonconsecutive	ADJ
aisthesis-3151	77	12	days	day	NOUN
aisthesis-3151	77	13	at	at	ADP
aisthesis-3151	77	14	3	3	NUM
aisthesis-3151	77	15	mu	mu	NOUN
aisthesis-3151	77	16	per	per	ADP
aisthesis-3151	77	17	dose	dose	NOUN
aisthesis-3151	77	18	during	during	ADP
aisthesis-3151	77	19	the	the	DET
aisthesis-3151	77	20	$	$	SYM
aisthesis-3151	77	21	rst	rst	NOUN
aisthesis-3151	77	22	week	week	NOUN
aisthesis-3151	77	23	,	,	PUNCT
aisthesis-3151	77	24	6	6	NUM
aisthesis-3151	77	25	mu	mu	NOUN
aisthesis-3151	77	26	per	per	ADP
aisthesis-3151	77	27	dose	dose	NOUN
aisthesis-3151	77	28	the	the	DET
aisthesis-3151	77	29	second	second	ADJ
aisthesis-3151	77	30	week	week	NOUN
aisthesis-3151	77	31	,	,	PUNCT
aisthesis-3151	77	32	and	and	CCONJ
aisthesis-3151	77	33	9	9	NUM
aisthesis-3151	77	34	mu	mu	NOUN
aisthesis-3151	77	35	per	per	ADP
aisthesis-3151	77	36	dose	dose	PROPN
aisthesis-3151	77	37	therea&er	therea&er	PROPN
aisthesis-3151	77	38	.	.	PUNCT
aisthesis-3151	78	1	pfs	pfs	PROPN
aisthesis-3151	78	2	conferred	confer	VERB
aisthesis-3151	78	3	with	with	ADP
aisthesis-3151	78	4	the	the	DET
aisthesis-3151	78	5	sunitinib	sunitinib	NOUN
aisthesis-3151	78	6	treatment	treatment	NOUN
aisthesis-3151	78	7	was	be	AUX
aisthesis-3151	78	8	approximately	approximately	ADV
aisthesis-3151	78	9	11	11	NUM
aisthesis-3151	78	10	months	month	NOUN
aisthesis-3151	78	11	,	,	PUNCT
aisthesis-3151	78	12	while	while	SCONJ
aisthesis-3151	78	13	pfs	pfs	PROPN
aisthesis-3151	78	14	conferred	confer	VERB
aisthesis-3151	78	15	with	with	ADP
aisthesis-3151	78	16	the	the	DET
aisthesis-3151	78	17	ifn-	ifn-	NOUN
aisthesis-3151	78	18	'	'	PUNCT
aisthesis-3151	78	19	treatment	treatment	NOUN
aisthesis-3151	78	20	was	be	AUX
aisthesis-3151	78	21	approximately	approximately	ADV
aisthesis-3151	78	22	5	5	NUM
aisthesis-3151	78	23	months	month	NOUN
aisthesis-3151	78	24	(	(	PUNCT
aisthesis-3151	78	25	motzer	motzer	NOUN
aisthesis-3151	78	26	et	et	PROPN
aisthesis-3151	78	27	al	al	PROPN
aisthesis-3151	78	28	.	.	PROPN
aisthesis-3151	78	29	,	,	PUNCT
aisthesis-3151	78	30	2007	2007	NUM
aisthesis-3151	78	31	)	)	PUNCT
aisthesis-3151	78	32	.	.	PUNCT
aisthesis-3151	78	33	!	!	PUNCT
aisthesis-3151	79	1	e	e	X
aisthesis-3151	79	2	past	past	NOUN
aisthesis-3151	79	3	,	,	PUNCT
aisthesis-3151	79	4	present	present	ADJ
aisthesis-3151	79	5	,	,	PUNCT
aisthesis-3151	79	6	and	and	CCONJ
aisthesis-3151	79	7	future	future	NOUN
aisthesis-3151	79	8	of	of	ADP
aisthesis-3151	79	9	renal	renal	ADJ
aisthesis-3151	79	10	cell	cell	NOUN
aisthesis-3151	79	11	carcinoma	carcinoma	NOUN
aisthesis-3151	79	12	treatment	treatment	NOUN
aisthesis-3151	79	13	aisthesis	aisthesis	NOUN
aisthesis-3151	79	14	volume	volume	NOUN
aisthesis-3151	79	15	11	11	NUM
aisthesis-3151	79	16	,	,	PUNCT
aisthesis-3151	79	17	20204	20204	NUM
aisthesis-3151	79	18	treatment	treatment	NOUN
aisthesis-3151	79	19	of	of	ADP
aisthesis-3151	79	20	renal	renal	ADJ
aisthesis-3151	79	21	cell	cell	NOUN
aisthesis-3151	79	22	carcinoma	carcinoma	NOUN
aisthesis-3151	79	23	.	.	PUNCT
aisthesis-3151	80	1	drugs	drug	NOUN
aisthesis-3151	80	2	of	of	ADP
aisthesis-3151	80	3	this	this	DET
aisthesis-3151	80	4	class	class	NOUN
aisthesis-3151	80	5	include	include	VERB
aisthesis-3151	80	6	sunitinib	sunitinib	NOUN
aisthesis-3151	80	7	,	,	PUNCT
aisthesis-3151	80	8	cabozantinib	cabozantinib	ADV
aisthesis-3151	80	9	,	,	PUNCT
aisthesis-3151	80	10	sorafenib	sorafenib	NOUN
aisthesis-3151	80	11	,	,	PUNCT
aisthesis-3151	80	12	and	and	CCONJ
aisthesis-3151	80	13	axitinib	axitinib	NOUN
aisthesis-3151	80	14	,	,	PUNCT
aisthesis-3151	80	15	among	among	ADP
aisthesis-3151	80	16	others	other	NOUN
aisthesis-3151	80	17	(	(	PUNCT
aisthesis-3151	80	18	figure	figure	NOUN
aisthesis-3151	80	19	3	3	NUM
aisthesis-3151	80	20	)	)	PUNCT
aisthesis-3151	80	21	,	,	PUNCT
aisthesis-3151	80	22	and	and	CCONJ
aisthesis-3151	80	23	each	each	DET
aisthesis-3151	80	24	drug	drug	NOUN
aisthesis-3151	80	25	inhibits	inhibit	VERB
aisthesis-3151	80	26	unique	unique	ADJ
aisthesis-3151	80	27	component(s	component(	NOUN
aisthesis-3151	80	28	)	)	PUNCT
aisthesis-3151	80	29	of	of	ADP
aisthesis-3151	80	30	the	the	DET
aisthesis-3151	80	31	angiogenesis	angiogenesis	NOUN
aisthesis-3151	80	32	pathway	pathway	NOUN
aisthesis-3151	80	33	.	.	PUNCT
aisthesis-3151	81	1	in	in	ADP
aisthesis-3151	81	2	mouse	mouse	PROPN
aisthesis-3151	81	3	xenogra	xenogra	PROPN
aisthesis-3151	81	4	&	&	CCONJ
aisthesis-3151	81	5	models	model	NOUN
aisthesis-3151	81	6	,	,	PUNCT
aisthesis-3151	81	7	sunitinib	sunitinib	NOUN
aisthesis-3151	81	8	was	be	AUX
aisthesis-3151	81	9	found	find	VERB
aisthesis-3151	81	10	to	to	PART
aisthesis-3151	81	11	reduce	reduce	VERB
aisthesis-3151	81	12	tumor	tumor	NOUN
aisthesis-3151	81	13	microvessel	microvessel	NOUN
aisthesis-3151	81	14	density	density	NOUN
aisthesis-3151	81	15	,	,	PUNCT
aisthesis-3151	81	16	con$rming	con$rme	VERB
aisthesis-3151	81	17	the	the	DET
aisthesis-3151	81	18	drug	drug	NOUN
aisthesis-3151	81	19	’s	’s	PART
aisthesis-3151	81	20	potential	potential	NOUN
aisthesis-3151	81	21	to	to	PART
aisthesis-3151	81	22	reduce	reduce	VERB
aisthesis-3151	81	23	angiogenesis	angiogenesis	NOUN
aisthesis-3151	81	24	and	and	CCONJ
aisthesis-3151	81	25	inhibit	inhibit	VERB
aisthesis-3151	81	26	tumor	tumor	NOUN
aisthesis-3151	81	27	growth	growth	NOUN
aisthesis-3151	81	28	(	(	PUNCT
aisthesis-3151	81	29	mendel	mendel	PROPN
aisthesis-3151	81	30	et	et	PROPN
aisthesis-3151	81	31	al	al	PROPN
aisthesis-3151	81	32	.	.	PROPN
aisthesis-3151	81	33	,	,	PUNCT
aisthesis-3151	81	34	2003	2003	NUM
aisthesis-3151	81	35	)	)	PUNCT
aisthesis-3151	81	36	.	.	PUNCT
aisthesis-3151	82	1	to	to	PART
aisthesis-3151	82	2	assess	assess	VERB
aisthesis-3151	82	3	whether	whether	SCONJ
aisthesis-3151	82	4	sunitinib	sunitinib	NOUN
aisthesis-3151	82	5	could	could	AUX
aisthesis-3151	82	6	further	far	ADV
aisthesis-3151	82	7	improve	improve	VERB
aisthesis-3151	82	8	survival	survival	NOUN
aisthesis-3151	83	1	bene$ts	bene$ts	PROPN
aisthesis-3151	83	2	o!ered	o!ere	VERB
aisthesis-3151	83	3	by	by	ADP
aisthesis-3151	83	4	cytokine	cytokine	NOUN
aisthesis-3151	83	5	immunotherapies	immunotherapy	NOUN
aisthesis-3151	83	6	in	in	ADP
aisthesis-3151	83	7	renal	renal	ADJ
aisthesis-3151	83	8	cell	cell	NOUN
aisthesis-3151	83	9	carcinoma	carcinoma	NOUN
aisthesis-3151	83	10	,	,	PUNCT
aisthesis-3151	83	11	a	a	DET
aisthesis-3151	83	12	phase	phase	NOUN
aisthesis-3151	83	13	iii	iii	NUM
aisthesis-3151	83	14	multicenter	multicenter	NOUN
aisthesis-3151	83	15	clinical	clinical	ADJ
aisthesis-3151	83	16	trial	trial	NOUN
aisthesis-3151	83	17	was	be	AUX
aisthesis-3151	83	18	formulated	formulate	VERB
aisthesis-3151	83	19	.	.	PUNCT
aisthesis-3151	84	1	#	#	NOUN
aisthesis-3151	84	2	is	be	AUX
aisthesis-3151	84	3	trial	trial	NOUN
aisthesis-3151	84	4	compared	compare	VERB
aisthesis-3151	84	5	progression	progression	NOUN
aisthesis-3151	84	6	-	-	PUNCT
aisthesis-3151	84	7	free	free	ADJ
aisthesis-3151	84	8	survival	survival	NOUN
aisthesis-3151	84	9	(	(	PUNCT
aisthesis-3151	84	10	pfs)—the	pfs)—the	DET
aisthesis-3151	84	11	time	time	NOUN
aisthesis-3151	84	12	between	between	ADP
aisthesis-3151	84	13	treatment	treatment	NOUN
aisthesis-3151	84	14	initiation	initiation	NOUN
aisthesis-3151	84	15	and	and	CCONJ
aisthesis-3151	84	16	observation	observation	NOUN
aisthesis-3151	84	17	of	of	ADP
aisthesis-3151	84	18	cancer	cancer	NOUN
aisthesis-3151	84	19	progression	progression	NOUN
aisthesis-3151	84	20	—	—	PUNCT
aisthesis-3151	84	21	in	in	ADP
aisthesis-3151	84	22	patients	patient	NOUN
aisthesis-3151	84	23	treated	treat	VERB
aisthesis-3151	84	24	with	with	ADP
aisthesis-3151	84	25	sunitinib	sunitinib	NOUN
aisthesis-3151	84	26	or	or	CCONJ
aisthesis-3151	84	27	ifn-	ifn-	X
aisthesis-3151	84	28	'	'	PUNCT
aisthesis-3151	84	29	(	(	PUNCT
aisthesis-3151	84	30	motzer	motzer	NOUN
aisthesis-3151	84	31	et	et	PROPN
aisthesis-3151	84	32	al	al	PROPN
aisthesis-3151	84	33	.	.	PROPN
aisthesis-3151	84	34	,	,	PUNCT
aisthesis-3151	84	35	2007	2007	NUM
aisthesis-3151	84	36	)	)	PUNCT
aisthesis-3151	84	37	.	.	PUNCT
aisthesis-3151	85	1	given	give	VERB
aisthesis-3151	85	2	pre	pre	ADJ
aisthesis-3151	85	3	-	-	ADJ
aisthesis-3151	85	4	clinical	clinical	ADJ
aisthesis-3151	85	5	evidence	evidence	NOUN
aisthesis-3151	85	6	of	of	ADP
aisthesis-3151	85	7	sunitinib	sunitinib	NOUN
aisthesis-3151	85	8	’s	’s	PART
aisthesis-3151	85	9	anti	anti	ADJ
aisthesis-3151	85	10	-	-	ADJ
aisthesis-3151	85	11	angiogenic	angiogenic	ADJ
aisthesis-3151	85	12	properties	property	NOUN
aisthesis-3151	85	13	and	and	CCONJ
aisthesis-3151	85	14	preliminary	preliminary	ADJ
aisthesis-3151	85	15	clinical	clinical	ADJ
aisthesis-3151	85	16	data	datum	NOUN
aisthesis-3151	85	17	,	,	PUNCT
aisthesis-3151	85	18	motzer	motzer	NOUN
aisthesis-3151	85	19	et	et	PROPN
aisthesis-3151	85	20	al	al	PROPN
aisthesis-3151	85	21	.	.	PROPN
aisthesis-3151	85	22	hypothesized	hypothesize	VERB
aisthesis-3151	85	23	that	that	SCONJ
aisthesis-3151	85	24	sunitinib	sunitinib	NOUN
aisthesis-3151	85	25	would	would	AUX
aisthesis-3151	85	26	yield	yield	VERB
aisthesis-3151	85	27	superior	superior	ADJ
aisthesis-3151	85	28	outcomes	outcome	NOUN
aisthesis-3151	85	29	when	when	SCONJ
aisthesis-3151	85	30	compared	compare	VERB
aisthesis-3151	85	31	with	with	ADP
aisthesis-3151	85	32	ifn-	ifn-	X
aisthesis-3151	85	33	'	'	PUNCT
aisthesis-3151	85	34	.	.	PUNCT
aisthesis-3151	86	1	in	in	ADP
aisthesis-3151	86	2	the	the	DET
aisthesis-3151	86	3	phase	phase	NOUN
aisthesis-3151	86	4	iii	iii	NOUN
aisthesis-3151	86	5	trial	trial	NOUN
aisthesis-3151	86	6	,	,	PUNCT
aisthesis-3151	86	7	motzer	motzer	NOUN
aisthesis-3151	86	8	et	et	PROPN
aisthesis-3151	86	9	al	al	PROPN
aisthesis-3151	86	10	.	.	PROPN
aisthesis-3151	86	11	included	include	VERB
aisthesis-3151	86	12	750	750	NUM
aisthesis-3151	86	13	patients	patient	NOUN
aisthesis-3151	86	14	with	with	ADP
aisthesis-3151	86	15	metastatic	metastatic	ADJ
aisthesis-3151	86	16	renal	renal	ADJ
aisthesis-3151	86	17	cell	cell	NOUN
aisthesis-3151	86	18	carcinoma	carcinoma	NOUN
aisthesis-3151	86	19	randomized	randomize	VERB
aisthesis-3151	86	20	in	in	ADP
aisthesis-3151	86	21	a	a	DET
aisthesis-3151	86	22	1:1	1:1	NUM
aisthesis-3151	86	23	ratio	ratio	NOUN
aisthesis-3151	86	24	to	to	ADP
aisthesis-3151	86	25	the	the	DET
aisthesis-3151	86	26	sunitinib	sunitinib	NOUN
aisthesis-3151	86	27	or	or	CCONJ
aisthesis-3151	86	28	ifn-	ifn-	NOUN
aisthesis-3151	86	29	'	'	PART
aisthesis-3151	86	30	treatment	treatment	NOUN
aisthesis-3151	86	31	arms	arm	NOUN
aisthesis-3151	86	32	.	.	PUNCT
aisthesis-3151	87	1	patients	patient	NOUN
aisthesis-3151	87	2	in	in	ADP
aisthesis-3151	87	3	both	both	DET
aisthesis-3151	87	4	groups	group	NOUN
aisthesis-3151	87	5	continued	continue	VERB
aisthesis-3151	87	6	treatment	treatment	NOUN
aisthesis-3151	87	7	until	until	ADP
aisthesis-3151	87	8	the	the	DET
aisthesis-3151	87	9	occurrence	occurrence	NOUN
aisthesis-3151	87	10	of	of	ADP
aisthesis-3151	87	11	disease	disease	NOUN
aisthesis-3151	87	12	progression	progression	NOUN
aisthesis-3151	87	13	.	.	PUNCT
aisthesis-3151	88	1	it	it	PRON
aisthesis-3151	88	2	was	be	AUX
aisthesis-3151	88	3	found	find	VERB
aisthesis-3151	88	4	that	that	SCONJ
aisthesis-3151	88	5	pfs	pfs	PROPN
aisthesis-3151	88	6	was	be	AUX
aisthesis-3151	88	7	signi$cantly	signi$cantly	ADV
aisthesis-3151	88	8	higher	high	ADJ
aisthesis-3151	88	9	for	for	ADP
aisthesis-3151	88	10	the	the	DET
aisthesis-3151	88	11	group	group	NOUN
aisthesis-3151	88	12	treated	treat	VERB
aisthesis-3151	88	13	with	with	ADP
aisthesis-3151	88	14	sunitinib	sunitinib	NOUN
aisthesis-3151	88	15	as	as	ADP
aisthesis-3151	88	16	compared	compare	VERB
aisthesis-3151	88	17	to	to	ADP
aisthesis-3151	88	18	ifn-	ifn-	X
aisthesis-3151	88	19	'	'	PUNCT
aisthesis-3151	88	20	(	(	PUNCT
aisthesis-3151	88	21	11	11	NUM
aisthesis-3151	88	22	months	month	NOUN
aisthesis-3151	88	23	vs.	vs.	ADP
aisthesis-3151	88	24	5	5	NUM
aisthesis-3151	88	25	months	month	NOUN
aisthesis-3151	88	26	,	,	PUNCT
aisthesis-3151	88	27	respectively	respectively	ADV
aisthesis-3151	88	28	;	;	PUNCT
aisthesis-3151	88	29	figure	figure	NOUN
aisthesis-3151	88	30	4	4	NUM
aisthesis-3151	88	31	)	)	PUNCT
aisthesis-3151	88	32	.	.	PUNCT
aisthesis-3151	89	1	furthermore	furthermore	ADV
aisthesis-3151	89	2	,	,	PUNCT
aisthesis-3151	89	3	a	a	DET
aisthesis-3151	89	4	greater	great	ADJ
aisthesis-3151	89	5	percentage	percentage	NOUN
aisthesis-3151	89	6	of	of	ADP
aisthesis-3151	89	7	patients	patient	NOUN
aisthesis-3151	89	8	treated	treat	VERB
aisthesis-3151	89	9	with	with	ADP
aisthesis-3151	89	10	ifn-	ifn-	X
aisthesis-3151	89	11	'	'	PUNCT
aisthesis-3151	89	12	had	have	AUX
aisthesis-3151	89	13	to	to	PART
aisthesis-3151	89	14	discontinue	discontinue	VERB
aisthesis-3151	89	15	treatment	treatment	NOUN
aisthesis-3151	89	16	due	due	ADP
aisthesis-3151	89	17	to	to	ADP
aisthesis-3151	89	18	secondary	secondary	ADJ
aisthesis-3151	89	19	medical	medical	ADJ
aisthesis-3151	89	20	consequences	consequence	NOUN
aisthesis-3151	89	21	of	of	ADP
aisthesis-3151	89	22	the	the	DET
aisthesis-3151	89	23	drug	drug	NOUN
aisthesis-3151	89	24	as	as	SCONJ
aisthesis-3151	89	25	compared	compare	VERB
aisthesis-3151	89	26	to	to	ADP
aisthesis-3151	89	27	those	those	PRON
aisthesis-3151	89	28	treated	treat	VERB
aisthesis-3151	89	29	with	with	ADP
aisthesis-3151	89	30	sunitinib	sunitinib	NOUN
aisthesis-3151	89	31	(	(	PUNCT
aisthesis-3151	89	32	13	13	NUM
aisthesis-3151	89	33	%	%	NOUN
aisthesis-3151	89	34	vs.	vs.	ADP
aisthesis-3151	89	35	8	8	NUM
aisthesis-3151	89	36	%	%	NOUN
aisthesis-3151	89	37	,	,	PUNCT
aisthesis-3151	89	38	respectively	respectively	ADV
aisthesis-3151	89	39	)	)	PUNCT
aisthesis-3151	89	40	.	.	PUNCT
aisthesis-3151	90	1	however	however	ADV
aisthesis-3151	90	2	,	,	PUNCT
aisthesis-3151	90	3	the	the	DET
aisthesis-3151	90	4	incidence	incidence	NOUN
aisthesis-3151	90	5	of	of	ADP
aisthesis-3151	90	6	certain	certain	ADJ
aisthesis-3151	90	7	toxicities	toxicity	NOUN
aisthesis-3151	90	8	was	be	AUX
aisthesis-3151	90	9	greater	great	ADJ
aisthesis-3151	90	10	in	in	ADP
aisthesis-3151	90	11	the	the	DET
aisthesis-3151	90	12	sunitinib	sunitinib	NOUN
aisthesis-3151	90	13	arm	arm	NOUN
aisthesis-3151	90	14	than	than	ADP
aisthesis-3151	90	15	the	the	DET
aisthesis-3151	90	16	ifn-	ifn-	NOUN
aisthesis-3151	90	17	'	'	PUNCT
aisthesis-3151	90	18	arm	arm	NOUN
aisthesis-3151	90	19	.	.	PUNCT
aisthesis-3151	91	1	6.4	6.4	NUM
aisthesis-3151	91	2	%	%	NOUN
aisthesis-3151	91	3	of	of	ADP
aisthesis-3151	91	4	patients	patient	NOUN
aisthesis-3151	91	5	on	on	ADP
aisthesis-3151	91	6	the	the	DET
aisthesis-3151	91	7	sunitinib	sunitinib	NOUN
aisthesis-3151	91	8	arm	arm	VERB
aisthesis-3151	91	9	experienced	experienced	ADJ
aisthesis-3151	91	10	hypertension	hypertension	NOUN
aisthesis-3151	91	11	,	,	PUNCT
aisthesis-3151	91	12	as	as	SCONJ
aisthesis-3151	91	13	compared	compare	VERB
aisthesis-3151	91	14	to	to	ADP
aisthesis-3151	91	15	0.3	0.3	NUM
aisthesis-3151	91	16	%	%	NOUN
aisthesis-3151	91	17	on	on	ADP
aisthesis-3151	91	18	the	the	DET
aisthesis-3151	91	19	ifn-	ifn-	NOUN
aisthesis-3151	91	20	'	'	PUNCT
aisthesis-3151	91	21	arm	arm	NOUN
aisthesis-3151	91	22	,	,	PUNCT
aisthesis-3151	91	23	and	and	CCONJ
aisthesis-3151	91	24	14.1	14.1	NUM
aisthesis-3151	91	25	%	%	NOUN
aisthesis-3151	91	26	of	of	ADP
aisthesis-3151	91	27	patients	patient	NOUN
aisthesis-3151	91	28	on	on	ADP
aisthesis-3151	91	29	the	the	DET
aisthesis-3151	91	30	sunitinib	sunitinib	NOUN
aisthesis-3151	91	31	arm	arm	VERB
aisthesis-3151	91	32	experienced	experienced	ADJ
aisthesis-3151	91	33	diarrhea	diarrhea	PROPN
aisthesis-3151	91	34	,	,	PUNCT
aisthesis-3151	91	35	as	as	SCONJ
aisthesis-3151	91	36	compared	compare	VERB
aisthesis-3151	91	37	to	to	ADP
aisthesis-3151	91	38	3.3	3.3	NUM
aisthesis-3151	91	39	%	%	NOUN
aisthesis-3151	91	40	on	on	ADP
aisthesis-3151	91	41	the	the	DET
aisthesis-3151	91	42	ifn-	ifn-	NOUN
aisthesis-3151	91	43	'	'	PUNCT
aisthesis-3151	91	44	arm	arm	NOUN
aisthesis-3151	91	45	.	.	PUNCT
aisthesis-3151	92	1	similar	similar	ADJ
aisthesis-3151	92	2	$	$	SYM
aisthesis-3151	92	3	ndings	nding	NOUN
aisthesis-3151	92	4	of	of	ADP
aisthesis-3151	92	5	enhanced	enhanced	ADJ
aisthesis-3151	92	6	survival	survival	NOUN
aisthesis-3151	92	7	,	,	PUNCT
aisthesis-3151	92	8	coupled	couple	VERB
aisthesis-3151	92	9	with	with	ADP
aisthesis-3151	92	10	cardiovascular	cardiovascular	ADJ
aisthesis-3151	92	11	toxicities	toxicity	NOUN
aisthesis-3151	92	12	during	during	ADP
aisthesis-3151	92	13	treatment	treatment	NOUN
aisthesis-3151	92	14	with	with	ADP
aisthesis-3151	92	15	vegf	vegf	PROPN
aisthesis-3151	92	16	-	-	PUNCT
aisthesis-3151	92	17	tkis	tkis	PROPN
aisthesis-3151	92	18	have	have	AUX
aisthesis-3151	92	19	been	be	AUX
aisthesis-3151	92	20	noted	note	VERB
aisthesis-3151	92	21	in	in	ADP
aisthesis-3151	92	22	subsequent	subsequent	ADJ
aisthesis-3151	92	23	clinical	clinical	ADJ
aisthesis-3151	92	24	studies	study	NOUN
aisthesis-3151	92	25	(	(	PUNCT
aisthesis-3151	92	26	schmidinger	schmidinger	NOUN
aisthesis-3151	92	27	et	et	PROPN
aisthesis-3151	92	28	al	al	PROPN
aisthesis-3151	92	29	.	.	PROPN
aisthesis-3151	92	30	,	,	PUNCT
aisthesis-3151	92	31	2008	2008	NUM
aisthesis-3151	92	32	;	;	PUNCT
aisthesis-3151	92	33	catino	catino	PROPN
aisthesis-3151	92	34	et	et	PROPN
aisthesis-3151	92	35	al	al	PROPN
aisthesis-3151	92	36	.	.	PROPN
aisthesis-3151	92	37	,	,	PUNCT
aisthesis-3151	92	38	2018	2018	NUM
aisthesis-3151	92	39	)	)	PUNCT
aisthesis-3151	92	40	.	.	PUNCT
aisthesis-3151	93	1	#	#	SYM
aisthesis-3151	93	2	e	e	NOUN
aisthesis-3151	93	3	development	development	NOUN
aisthesis-3151	93	4	of	of	ADP
aisthesis-3151	93	5	vegf	vegf	PROPN
aisthesis-3151	93	6	-	-	PUNCT
aisthesis-3151	93	7	tkis	tkis	PROPN
aisthesis-3151	93	8	was	be	AUX
aisthesis-3151	93	9	a	a	DET
aisthesis-3151	93	10	major	major	ADJ
aisthesis-3151	93	11	landmark	landmark	NOUN
aisthesis-3151	93	12	in	in	ADP
aisthesis-3151	93	13	renal	renal	ADJ
aisthesis-3151	93	14	cell	cell	NOUN
aisthesis-3151	93	15	carcinoma	carcinoma	NOUN
aisthesis-3151	93	16	treatment	treatment	NOUN
aisthesis-3151	93	17	.	.	PUNCT
aisthesis-3151	94	1	#	#	SYM
aisthesis-3151	94	2	e	e	NOUN
aisthesis-3151	94	3	phase	phase	NOUN
aisthesis-3151	94	4	iii	iii	NUM
aisthesis-3151	94	5	trial	trial	NOUN
aisthesis-3151	94	6	led	lead	VERB
aisthesis-3151	94	7	by	by	ADP
aisthesis-3151	94	8	motzer	motzer	NOUN
aisthesis-3151	94	9	et	et	PROPN
aisthesis-3151	94	10	al	al	PROPN
aisthesis-3151	94	11	.	.	PROPN
aisthesis-3151	94	12	showed	show	VERB
aisthesis-3151	94	13	that	that	SCONJ
aisthesis-3151	94	14	targeted	target	VERB
aisthesis-3151	94	15	inhibition	inhibition	NOUN
aisthesis-3151	94	16	of	of	ADP
aisthesis-3151	94	17	the	the	DET
aisthesis-3151	94	18	angiogenesis	angiogenesis	NOUN
aisthesis-3151	94	19	pathway	pathway	NOUN
aisthesis-3151	94	20	with	with	ADP
aisthesis-3151	94	21	sunitinib	sunitinib	NOUN
aisthesis-3151	94	22	could	could	AUX
aisthesis-3151	94	23	improve	improve	VERB
aisthesis-3151	94	24	pfs	pfs	PROPN
aisthesis-3151	94	25	and	and	CCONJ
aisthesis-3151	94	26	quality	quality	NOUN
aisthesis-3151	94	27	-	-	PUNCT
aisthesis-3151	94	28	of	of	ADP
aisthesis-3151	94	29	-	-	PUNCT
aisthesis-3151	94	30	life	life	NOUN
aisthesis-3151	94	31	in	in	ADP
aisthesis-3151	94	32	patients	patient	NOUN
aisthesis-3151	94	33	with	with	ADP
aisthesis-3151	94	34	metastatic	metastatic	ADJ
aisthesis-3151	94	35	renal	renal	ADJ
aisthesis-3151	94	36	cell	cell	NOUN
aisthesis-3151	94	37	carcinoma	carcinoma	NOUN
aisthesis-3151	94	38	.	.	PUNCT
aisthesis-3151	95	1	yet	yet	ADV
aisthesis-3151	95	2	,	,	PUNCT
aisthesis-3151	95	3	the	the	DET
aisthesis-3151	95	4	upsurge	upsurge	NOUN
aisthesis-3151	95	5	of	of	ADP
aisthesis-3151	95	6	cardiovascular	cardiovascular	ADJ
aisthesis-3151	95	7	toxicities	toxicity	NOUN
aisthesis-3151	95	8	became	become	VERB
aisthesis-3151	95	9	of	of	ADP
aisthesis-3151	95	10	concern	concern	NOUN
aisthesis-3151	95	11	when	when	SCONJ
aisthesis-3151	95	12	prescribing	prescribing	NOUN
aisthesis-3151	95	13	sunitinib	sunitinib	NOUN
aisthesis-3151	95	14	.	.	PUNCT
aisthesis-3151	96	1	it	it	PRON
aisthesis-3151	96	2	is	be	AUX
aisthesis-3151	96	3	known	know	VERB
aisthesis-3151	96	4	that	that	SCONJ
aisthesis-3151	96	5	the	the	DET
aisthesis-3151	96	6	same	same	ADJ
aisthesis-3151	96	7	vegf	vegf	NOUN
aisthesis-3151	96	8	pathway	pathway	NOUN
aisthesis-3151	96	9	is	be	AUX
aisthesis-3151	96	10	used	use	VERB
aisthesis-3151	96	11	by	by	ADP
aisthesis-3151	96	12	healthy	healthy	ADJ
aisthesis-3151	96	13	cells	cell	NOUN
aisthesis-3151	96	14	,	,	PUNCT
aisthesis-3151	96	15	such	such	ADJ
aisthesis-3151	96	16	as	as	ADP
aisthesis-3151	96	17	those	those	PRON
aisthesis-3151	96	18	in	in	ADP
aisthesis-3151	96	19	the	the	DET
aisthesis-3151	96	20	cardiovascular	cardiovascular	ADJ
aisthesis-3151	96	21	system	system	NOUN
aisthesis-3151	96	22	,	,	PUNCT
aisthesis-3151	96	23	to	to	PART
aisthesis-3151	96	24	receive	receive	VERB
aisthesis-3151	96	25	figure	figure	NOUN
aisthesis-3151	96	26	5	5	NUM
aisthesis-3151	96	27	:	:	PUNCT
aisthesis-3151	96	28	nivolumab	nivolumab	NOUN
aisthesis-3151	96	29	and	and	CCONJ
aisthesis-3151	96	30	ipilimumab	ipilimumab	ADJ
aisthesis-3151	96	31	mechanism	mechanism	NOUN
aisthesis-3151	96	32	of	of	ADP
aisthesis-3151	96	33	action	action	NOUN
aisthesis-3151	96	34	.	.	PUNCT
aisthesis-3151	97	1	a	a	DET
aisthesis-3151	97	2	)	)	PUNCT
aisthesis-3151	97	3	nivolumab	nivolumab	NOUN
aisthesis-3151	97	4	is	be	AUX
aisthesis-3151	97	5	an	an	DET
aisthesis-3151	97	6	antibody	antibody	NOUN
aisthesis-3151	97	7	that	that	PRON
aisthesis-3151	97	8	binds	bind	VERB
aisthesis-3151	97	9	to	to	ADP
aisthesis-3151	97	10	the	the	DET
aisthesis-3151	97	11	pd-1	pd-1	NOUN
aisthesis-3151	97	12	.	.	PUNCT
aisthesis-3151	98	1	while	while	SCONJ
aisthesis-3151	98	2	pd-1	pd-1	ADV
aisthesis-3151	98	3	normally	normally	ADV
aisthesis-3151	98	4	binds	bind	VERB
aisthesis-3151	98	5	programmed	program	VERB
aisthesis-3151	98	6	death	death	NOUN
aisthesis-3151	98	7	-	-	PUNCT
aisthesis-3151	98	8	ligand	ligand	NOUN
aisthesis-3151	98	9	1	1	NUM
aisthesis-3151	98	10	(	(	PUNCT
aisthesis-3151	98	11	pd	pd	NOUN
aisthesis-3151	98	12	-	-	PUNCT
aisthesis-3151	98	13	l1	l1	NOUN
aisthesis-3151	98	14	)	)	PUNCT
aisthesis-3151	98	15	expressed	express	VERB
aisthesis-3151	98	16	on	on	ADP
aisthesis-3151	98	17	tumor	tumor	NOUN
aisthesis-3151	98	18	cells	cell	NOUN
aisthesis-3151	98	19	,	,	PUNCT
aisthesis-3151	98	20	ultimately	ultimately	ADV
aisthesis-3151	98	21	resulting	result	VERB
aisthesis-3151	98	22	in	in	ADP
aisthesis-3151	98	23	death	death	NOUN
aisthesis-3151	98	24	of	of	ADP
aisthesis-3151	98	25	the	the	DET
aisthesis-3151	98	26	t	t	NOUN
aisthesis-3151	98	27	cell	cell	NOUN
aisthesis-3151	98	28	,	,	PUNCT
aisthesis-3151	98	29	nivolumab	nivolumab	ADV
aisthesis-3151	98	30	binds	bind	VERB
aisthesis-3151	98	31	with	with	ADP
aisthesis-3151	98	32	greater	great	ADJ
aisthesis-3151	98	33	a(nity	a(nity	NOUN
aisthesis-3151	98	34	,	,	PUNCT
aisthesis-3151	98	35	thereby	thereby	ADV
aisthesis-3151	98	36	preventing	prevent	VERB
aisthesis-3151	98	37	death	death	NOUN
aisthesis-3151	98	38	of	of	ADP
aisthesis-3151	98	39	the	the	DET
aisthesis-3151	98	40	t	t	NOUN
aisthesis-3151	98	41	cell	cell	NOUN
aisthesis-3151	98	42	(	(	PUNCT
aisthesis-3151	98	43	guo	guo	PROPN
aisthesis-3151	98	44	et	et	PROPN
aisthesis-3151	98	45	al	al	PROPN
aisthesis-3151	98	46	.	.	PROPN
aisthesis-3151	98	47	,	,	PUNCT
aisthesis-3151	98	48	2017	2017	NUM
aisthesis-3151	98	49	)	)	PUNCT
aisthesis-3151	98	50	.	.	PUNCT
aisthesis-3151	99	1	b	b	X
aisthesis-3151	99	2	)	)	PUNCT
aisthesis-3151	99	3	full	full	ADJ
aisthesis-3151	99	4	activation	activation	NOUN
aisthesis-3151	99	5	of	of	ADP
aisthesis-3151	99	6	the	the	DET
aisthesis-3151	99	7	t	t	NOUN
aisthesis-3151	99	8	cell	cell	NOUN
aisthesis-3151	99	9	involves	involve	VERB
aisthesis-3151	99	10	binding	bind	VERB
aisthesis-3151	99	11	of	of	ADP
aisthesis-3151	99	12	the	the	DET
aisthesis-3151	99	13	antigen	antigen	NOUN
aisthesis-3151	99	14	from	from	ADP
aisthesis-3151	99	15	the	the	DET
aisthesis-3151	99	16	antigen	antigen	NOUN
aisthesis-3151	99	17	-	-	PUNCT
aisthesis-3151	99	18	presenting	present	VERB
aisthesis-3151	99	19	cell	cell	NOUN
aisthesis-3151	99	20	(	(	PUNCT
aisthesis-3151	99	21	le	le	X
aisthesis-3151	99	22	&	&	CCONJ
aisthesis-3151	99	23	)	)	PUNCT
aisthesis-3151	99	24	and	and	CCONJ
aisthesis-3151	99	25	binding	bind	VERB
aisthesis-3151	99	26	of	of	ADP
aisthesis-3151	99	27	co	co	NOUN
aisthesis-3151	99	28	-	-	NOUN
aisthesis-3151	99	29	receptor	receptor	NOUN
aisthesis-3151	99	30	cd28	cd28	PROPN
aisthesis-3151	99	31	with	with	ADP
aisthesis-3151	99	32	a	a	DET
aisthesis-3151	99	33	receptor	receptor	NOUN
aisthesis-3151	99	34	(	(	PUNCT
aisthesis-3151	99	35	b7	b7	PROPN
aisthesis-3151	99	36	)	)	PUNCT
aisthesis-3151	99	37	on	on	ADP
aisthesis-3151	99	38	the	the	DET
aisthesis-3151	99	39	antigen	antigen	NOUN
aisthesis-3151	99	40	-	-	PUNCT
aisthesis-3151	99	41	presenting	present	VERB
aisthesis-3151	99	42	cell	cell	NOUN
aisthesis-3151	99	43	.	.	PUNCT
aisthesis-3151	100	1	normally	normally	ADV
aisthesis-3151	100	2	,	,	PUNCT
aisthesis-3151	100	3	the	the	DET
aisthesis-3151	100	4	second	second	ADJ
aisthesis-3151	100	5	receptor	receptor	NOUN
aisthesis-3151	100	6	on	on	ADP
aisthesis-3151	100	7	the	the	DET
aisthesis-3151	100	8	antigen	antigen	NOUN
aisthesis-3151	100	9	-	-	PUNCT
aisthesis-3151	100	10	presenting	present	VERB
aisthesis-3151	100	11	cell	cell	NOUN
aisthesis-3151	100	12	(	(	PUNCT
aisthesis-3151	100	13	b7	b7	PROPN
aisthesis-3151	100	14	)	)	PUNCT
aisthesis-3151	100	15	binds	bind	VERB
aisthesis-3151	100	16	to	to	ADP
aisthesis-3151	100	17	ctla-4	ctla-4	NUM
aisthesis-3151	100	18	,	,	PUNCT
aisthesis-3151	100	19	thereby	thereby	ADV
aisthesis-3151	100	20	hindering	hinder	VERB
aisthesis-3151	100	21	t	t	PROPN
aisthesis-3151	100	22	cell	cell	NOUN
aisthesis-3151	100	23	activation	activation	NOUN
aisthesis-3151	100	24	.	.	PUNCT
aisthesis-3151	101	1	c	c	X
aisthesis-3151	101	2	)	)	PUNCT
aisthesis-3151	101	3	ipilimumab	ipilimumab	NOUN
aisthesis-3151	101	4	(	(	PUNCT
aisthesis-3151	101	5	denoted	denote	VERB
aisthesis-3151	101	6	as	as	ADP
aisthesis-3151	101	7	'	'	PUNCT
aisthesis-3151	101	8	ctla-4	ctla-4	NOUN
aisthesis-3151	101	9	)	)	PUNCT
aisthesis-3151	101	10	binds	bind	VERB
aisthesis-3151	101	11	to	to	ADP
aisthesis-3151	101	12	the	the	DET
aisthesis-3151	101	13	ctla-4	ctla-4	NOUN
aisthesis-3151	101	14	receptor	receptor	NOUN
aisthesis-3151	101	15	on	on	ADP
aisthesis-3151	101	16	the	the	DET
aisthesis-3151	101	17	t	t	NOUN
aisthesis-3151	101	18	cell	cell	NOUN
aisthesis-3151	101	19	,	,	PUNCT
aisthesis-3151	101	20	inducing	induce	VERB
aisthesis-3151	101	21	full	full	ADJ
aisthesis-3151	101	22	activation	activation	NOUN
aisthesis-3151	101	23	of	of	ADP
aisthesis-3151	101	24	the	the	DET
aisthesis-3151	101	25	t	t	NOUN
aisthesis-3151	101	26	cell	cell	NOUN
aisthesis-3151	101	27	.	.	PUNCT
aisthesis-3151	102	1	b	b	NOUN
aisthesis-3151	102	2	and	and	CCONJ
aisthesis-3151	102	3	c	c	PROPN
aisthesis-3151	102	4	are	be	AUX
aisthesis-3151	102	5	adapted	adapt	VERB
aisthesis-3151	102	6	from	from	ADP
aisthesis-3151	102	7	lipson	lipson	PROPN
aisthesis-3151	102	8	&	&	CCONJ
aisthesis-3151	102	9	drake	drake	PROPN
aisthesis-3151	102	10	,	,	PUNCT
aisthesis-3151	102	11	2011	2011	NUM
aisthesis-3151	102	12	.	.	PUNCT
aisthesis-3151	102	13	!	!	PUNCT
aisthesis-3151	103	1	e	e	X
aisthesis-3151	103	2	past	past	NOUN
aisthesis-3151	103	3	,	,	PUNCT
aisthesis-3151	103	4	present	present	ADJ
aisthesis-3151	103	5	,	,	PUNCT
aisthesis-3151	103	6	and	and	CCONJ
aisthesis-3151	103	7	future	future	NOUN
aisthesis-3151	103	8	of	of	ADP
aisthesis-3151	103	9	renal	renal	ADJ
aisthesis-3151	103	10	cell	cell	NOUN
aisthesis-3151	103	11	carcinoma	carcinoma	NOUN
aisthesis-3151	103	12	treatment	treatment	NOUN
aisthesis-3151	103	13	aisthesis	aisthesis	NOUN
aisthesis-3151	103	14	volume	volume	NOUN
aisthesis-3151	103	15	11	11	NUM
aisthesis-3151	103	16	,	,	PUNCT
aisthesis-3151	103	17	20205	20205	NUM
aisthesis-3151	103	18	nutrients	nutrient	NOUN
aisthesis-3151	103	19	from	from	ADP
aisthesis-3151	103	20	blood	blood	NOUN
aisthesis-3151	103	21	.	.	PUNCT
aisthesis-3151	104	1	renal	renal	ADJ
aisthesis-3151	104	2	cell	cell	NOUN
aisthesis-3151	104	3	carcinoma	carcinoma	NOUN
aisthesis-3151	104	4	patients	patient	NOUN
aisthesis-3151	104	5	who	who	PRON
aisthesis-3151	104	6	present	present	VERB
aisthesis-3151	104	7	with	with	ADP
aisthesis-3151	104	8	poor	poor	ADJ
aisthesis-3151	104	9	cardiovascular	cardiovascular	ADJ
aisthesis-3151	104	10	health	health	NOUN
aisthesis-3151	104	11	are	be	AUX
aisthesis-3151	104	12	o&en	o&en	VERB
aisthesis-3151	104	13	administered	administer	VERB
aisthesis-3151	104	14	sunitinib	sunitinib	NOUN
aisthesis-3151	104	15	in	in	ADP
aisthesis-3151	104	16	combination	combination	NOUN
aisthesis-3151	104	17	with	with	ADP
aisthesis-3151	104	18	drugs	drug	NOUN
aisthesis-3151	104	19	that	that	PRON
aisthesis-3151	104	20	moderate	moderate	ADJ
aisthesis-3151	104	21	hypertension	hypertension	NOUN
aisthesis-3151	104	22	.	.	PUNCT
aisthesis-3151	105	1	if	if	SCONJ
aisthesis-3151	105	2	cardiovascular	cardiovascular	ADJ
aisthesis-3151	105	3	health	health	NOUN
aisthesis-3151	105	4	is	be	AUX
aisthesis-3151	105	5	to	to	ADP
aisthesis-3151	105	6	the	the	DET
aisthesis-3151	105	7	point	point	NOUN
aisthesis-3151	105	8	that	that	SCONJ
aisthesis-3151	105	9	the	the	DET
aisthesis-3151	105	10	safety	safety	NOUN
aisthesis-3151	105	11	of	of	ADP
aisthesis-3151	105	12	the	the	DET
aisthesis-3151	105	13	patient	patient	NOUN
aisthesis-3151	105	14	would	would	AUX
aisthesis-3151	105	15	be	be	AUX
aisthesis-3151	105	16	compromised	compromise	VERB
aisthesis-3151	105	17	with	with	ADP
aisthesis-3151	105	18	vegf	vegf	PROPN
aisthesis-3151	105	19	-	-	PUNCT
aisthesis-3151	105	20	tkis	tkis	PROPN
aisthesis-3151	105	21	,	,	PUNCT
aisthesis-3151	105	22	sunitinib	sunitinib	NOUN
aisthesis-3151	105	23	is	be	AUX
aisthesis-3151	105	24	forgone	forgo	VERB
aisthesis-3151	105	25	completely	completely	ADV
aisthesis-3151	105	26	.	.	PUNCT
aisthesis-3151	106	1	nevertheless	nevertheless	ADV
aisthesis-3151	106	2	,	,	PUNCT
aisthesis-3151	106	3	the	the	DET
aisthesis-3151	106	4	e(cacy	e(cacy	NOUN
aisthesis-3151	106	5	of	of	ADP
aisthesis-3151	106	6	sunitinib	sunitinib	NOUN
aisthesis-3151	106	7	in	in	ADP
aisthesis-3151	106	8	improving	improve	VERB
aisthesis-3151	106	9	survival	survival	NOUN
aisthesis-3151	106	10	outcomes	outcome	NOUN
aisthesis-3151	106	11	led	lead	VERB
aisthesis-3151	106	12	to	to	ADP
aisthesis-3151	106	13	its	its	PRON
aisthesis-3151	106	14	establishment	establishment	NOUN
aisthesis-3151	106	15	as	as	ADP
aisthesis-3151	106	16	a	a	DET
aisthesis-3151	106	17	$	$	SYM
aisthesis-3151	106	18	rst	rst	NOUN
aisthesis-3151	106	19	-	-	PUNCT
aisthesis-3151	106	20	line	line	NOUN
aisthesis-3151	106	21	of	of	ADP
aisthesis-3151	106	22	therapy	therapy	NOUN
aisthesis-3151	106	23	for	for	ADP
aisthesis-3151	106	24	renal	renal	ADJ
aisthesis-3151	106	25	cell	cell	NOUN
aisthesis-3151	106	26	carcinoma	carcinoma	NOUN
aisthesis-3151	106	27	in	in	ADP
aisthesis-3151	106	28	the	the	DET
aisthesis-3151	106	29	post	post	ADJ
aisthesis-3151	106	30	-	-	ADJ
aisthesis-3151	106	31	surgery	surgery	ADJ
aisthesis-3151	106	32	or	or	CCONJ
aisthesis-3151	106	33	radiation	radiation	NOUN
aisthesis-3151	106	34	setting	setting	NOUN
aisthesis-3151	106	35	.	.	PUNCT
aisthesis-3151	107	1	#	#	SYM
aisthesis-3151	107	2	e	e	NOUN
aisthesis-3151	107	3	revolutionary	revolutionary	ADJ
aisthesis-3151	107	4	paradigm	paradigm	NOUN
aisthesis-3151	107	5	of	of	ADP
aisthesis-3151	107	6	targeted	target	VERB
aisthesis-3151	107	7	,	,	PUNCT
aisthesis-3151	107	8	pathwayspeci$c	pathwayspeci$c	PROPN
aisthesis-3151	107	9	cancer	cancer	NOUN
aisthesis-3151	107	10	therapies	therapy	NOUN
aisthesis-3151	107	11	has	have	AUX
aisthesis-3151	107	12	since	since	ADV
aisthesis-3151	107	13	been	be	AUX
aisthesis-3151	107	14	explored	explore	VERB
aisthesis-3151	107	15	in	in	ADP
aisthesis-3151	107	16	the	the	DET
aisthesis-3151	107	17	immunological	immunological	ADJ
aisthesis-3151	107	18	context	context	NOUN
aisthesis-3151	107	19	.	.	PUNCT
aisthesis-3151	108	1	2009	2009	NUM
aisthesis-3151	108	2	-	-	PUNCT
aisthesis-3151	108	3	present	present	PROPN
aisthesis-3151	108	4	&	&	CCONJ
aisthesis-3151	108	5	future	future	NOUN
aisthesis-3151	108	6	:	:	PUNCT
aisthesis-3151	108	7	targeted	target	VERB
aisthesis-3151	108	8	immunotherapies	immunotherapy	NOUN
aisthesis-3151	108	9	:	:	PUNCT
aisthesis-3151	108	10	stimulating	stimulate	VERB
aisthesis-3151	108	11	the	the	DET
aisthesis-3151	108	12	immune	immune	ADJ
aisthesis-3151	108	13	system	system	NOUN
aisthesis-3151	108	14	at	at	ADP
aisthesis-3151	108	15	a	a	DET
aisthesis-3151	108	16	more	more	ADV
aisthesis-3151	108	17	re#ned	re#ne	VERB
aisthesis-3151	108	18	level	level	NOUN
aisthesis-3151	108	19	in	in	ADP
aisthesis-3151	108	20	an	an	DET
aisthesis-3151	108	21	attempt	attempt	NOUN
aisthesis-3151	108	22	to	to	ADP
aisthesis-3151	108	23	o!er	o!er	NUM
aisthesis-3151	108	24	further	further	ADJ
aisthesis-3151	108	25	lines	line	NOUN
aisthesis-3151	108	26	of	of	ADP
aisthesis-3151	108	27	treatment	treatment	NOUN
aisthesis-3151	108	28	for	for	ADP
aisthesis-3151	108	29	metastatic	metastatic	ADJ
aisthesis-3151	108	30	renal	renal	ADJ
aisthesis-3151	108	31	cell	cell	NOUN
aisthesis-3151	108	32	carcinoma	carcinoma	NOUN
aisthesis-3151	108	33	patients	patient	NOUN
aisthesis-3151	108	34	,	,	PUNCT
aisthesis-3151	108	35	investigators	investigator	NOUN
aisthesis-3151	108	36	revisited	revisit	VERB
aisthesis-3151	108	37	the	the	DET
aisthesis-3151	108	38	idea	idea	NOUN
aisthesis-3151	108	39	of	of	ADP
aisthesis-3151	108	40	renal	renal	ADJ
aisthesis-3151	108	41	cell	cell	NOUN
aisthesis-3151	108	42	carcinoma	carcinoma	NOUN
aisthesis-3151	108	43	as	as	ADP
aisthesis-3151	108	44	“	"	PUNCT
aisthesis-3151	108	45	immunogenic	immunogenic	ADJ
aisthesis-3151	108	46	”	"	PUNCT
aisthesis-3151	108	47	with	with	ADP
aisthesis-3151	108	48	the	the	DET
aisthesis-3151	108	49	paradigm	paradigm	NOUN
aisthesis-3151	108	50	of	of	ADP
aisthesis-3151	108	51	targeted	target	VERB
aisthesis-3151	108	52	therapies	therapy	NOUN
aisthesis-3151	108	53	.	.	PUNCT
aisthesis-3151	109	1	in	in	ADP
aisthesis-3151	109	2	2004	2004	NUM
aisthesis-3151	109	3	,	,	PUNCT
aisthesis-3151	109	4	it	it	PRON
aisthesis-3151	109	5	was	be	AUX
aisthesis-3151	109	6	$	$	SYM
aisthesis-3151	109	7	rst	rst	NOUN
aisthesis-3151	109	8	reported	report	VERB
aisthesis-3151	109	9	that	that	SCONJ
aisthesis-3151	109	10	t	t	PROPN
aisthesis-3151	109	11	cells	cell	NOUN
aisthesis-3151	109	12	,	,	PUNCT
aisthesis-3151	109	13	particularly	particularly	ADV
aisthesis-3151	109	14	cytotoxic	cytotoxic	ADJ
aisthesis-3151	109	15	t	t	NOUN
aisthesis-3151	109	16	cells	cell	NOUN
aisthesis-3151	109	17	,	,	PUNCT
aisthesis-3151	109	18	could	could	AUX
aisthesis-3151	109	19	be	be	AUX
aisthesis-3151	109	20	isolated	isolate	VERB
aisthesis-3151	109	21	in	in	ADP
aisthesis-3151	109	22	higher	high	ADJ
aisthesis-3151	109	23	levels	level	NOUN
aisthesis-3151	109	24	from	from	ADP
aisthesis-3151	109	25	patients	patient	NOUN
aisthesis-3151	109	26	with	with	ADP
aisthesis-3151	109	27	regressing	regress	VERB
aisthesis-3151	109	28	metastatic	metastatic	ADJ
aisthesis-3151	109	29	kidney	kidney	NOUN
aisthesis-3151	109	30	cancer	cancer	NOUN
aisthesis-3151	109	31	(	(	PUNCT
aisthesis-3151	109	32	takahashi	takahashi	PROPN
aisthesis-3151	109	33	et	et	PROPN
aisthesis-3151	109	34	al	al	PROPN
aisthesis-3151	109	35	.	.	PROPN
aisthesis-3151	109	36	,	,	PUNCT
aisthesis-3151	109	37	2004	2004	NUM
aisthesis-3151	109	38	)	)	PUNCT
aisthesis-3151	109	39	.	.	PUNCT
aisthesis-3151	110	1	subsequent	subsequent	ADJ
aisthesis-3151	110	2	studies	study	NOUN
aisthesis-3151	110	3	revealed	reveal	VERB
aisthesis-3151	110	4	that	that	SCONJ
aisthesis-3151	110	5	increased	increase	VERB
aisthesis-3151	110	6	expression	expression	NOUN
aisthesis-3151	110	7	of	of	ADP
aisthesis-3151	110	8	pd	pd	PROPN
aisthesis-3151	110	9	-	-	PROPN
aisthesis-3151	110	10	l1	l1	PROPN
aisthesis-3151	110	11	(	(	PUNCT
aisthesis-3151	110	12	programmed	program	VERB
aisthesis-3151	110	13	-	-	PUNCT
aisthesis-3151	110	14	death	death	NOUN
aisthesis-3151	110	15	ligand	ligand	NOUN
aisthesis-3151	110	16	1	1	NUM
aisthesis-3151	110	17	)	)	PUNCT
aisthesis-3151	110	18	molecules	molecule	NOUN
aisthesis-3151	110	19	on	on	ADP
aisthesis-3151	110	20	the	the	DET
aisthesis-3151	110	21	cell	cell	NOUN
aisthesis-3151	110	22	surface	surface	NOUN
aisthesis-3151	110	23	of	of	ADP
aisthesis-3151	110	24	cancer	cancer	NOUN
aisthesis-3151	110	25	cells	cell	NOUN
aisthesis-3151	110	26	over	over	ADP
aisthesis-3151	110	27	time	time	NOUN
aisthesis-3151	110	28	is	be	AUX
aisthesis-3151	110	29	associated	associate	VERB
aisthesis-3151	110	30	with	with	ADP
aisthesis-3151	110	31	a	a	DET
aisthesis-3151	110	32	poor	poor	ADJ
aisthesis-3151	110	33	prognosis	prognosis	NOUN
aisthesis-3151	110	34	in	in	ADP
aisthesis-3151	110	35	renal	renal	ADJ
aisthesis-3151	110	36	cell	cell	NOUN
aisthesis-3151	110	37	carcinoma	carcinoma	NOUN
aisthesis-3151	110	38	patients	patient	NOUN
aisthesis-3151	110	39	because	because	SCONJ
aisthesis-3151	110	40	pd	pd	PROPN
aisthesis-3151	110	41	-	-	PUNCT
aisthesis-3151	110	42	l1	l1	PROPN
aisthesis-3151	110	43	binds	bind	VERB
aisthesis-3151	110	44	to	to	ADP
aisthesis-3151	110	45	the	the	DET
aisthesis-3151	110	46	pd-1	pd-1	ADJ
aisthesis-3151	110	47	(	(	PUNCT
aisthesis-3151	110	48	programmed	program	VERB
aisthesis-3151	110	49	death	death	NOUN
aisthesis-3151	110	50	protein-1	protein-1	NOUN
aisthesis-3151	110	51	)	)	PUNCT
aisthesis-3151	110	52	receptors	receptor	NOUN
aisthesis-3151	110	53	on	on	ADP
aisthesis-3151	110	54	the	the	DET
aisthesis-3151	110	55	t	t	NOUN
aisthesis-3151	110	56	cell	cell	NOUN
aisthesis-3151	110	57	,	,	PUNCT
aisthesis-3151	110	58	thereby	thereby	ADV
aisthesis-3151	110	59	inhibiting	inhibit	VERB
aisthesis-3151	110	60	the	the	DET
aisthesis-3151	110	61	t	t	NOUN
aisthesis-3151	110	62	cell	cell	NOUN
aisthesis-3151	110	63	-	-	PUNCT
aisthesis-3151	110	64	mediated	mediate	VERB
aisthesis-3151	110	65	immune	immune	ADJ
aisthesis-3151	110	66	response	response	NOUN
aisthesis-3151	110	67	(	(	PUNCT
aisthesis-3151	110	68	#	#	SYM
aisthesis-3151	110	69	ompson	ompson	NOUN
aisthesis-3151	110	70	et	et	NOUN
aisthesis-3151	110	71	al	al	PROPN
aisthesis-3151	110	72	.	.	PROPN
aisthesis-3151	110	73	,	,	PUNCT
aisthesis-3151	110	74	2006	2006	NUM
aisthesis-3151	110	75	)	)	PUNCT
aisthesis-3151	110	76	.	.	PUNCT
aisthesis-3151	111	1	by	by	ADP
aisthesis-3151	111	2	inducing	induce	VERB
aisthesis-3151	111	3	death	death	NOUN
aisthesis-3151	111	4	of	of	ADP
aisthesis-3151	111	5	the	the	DET
aisthesis-3151	111	6	t	t	NOUN
aisthesis-3151	111	7	cells	cell	NOUN
aisthesis-3151	111	8	,	,	PUNCT
aisthesis-3151	111	9	cancer	cancer	NOUN
aisthesis-3151	111	10	cells	cell	NOUN
aisthesis-3151	111	11	could	could	AUX
aisthesis-3151	111	12	evade	evade	VERB
aisthesis-3151	111	13	the	the	DET
aisthesis-3151	111	14	host	host	NOUN
aisthesis-3151	111	15	immune	immune	ADJ
aisthesis-3151	111	16	system	system	NOUN
aisthesis-3151	111	17	.	.	PUNCT
aisthesis-3151	112	1	together	together	ADV
aisthesis-3151	112	2	,	,	PUNCT
aisthesis-3151	112	3	these	these	DET
aisthesis-3151	112	4	two	two	NUM
aisthesis-3151	112	5	discoveries	discovery	NOUN
aisthesis-3151	112	6	created	create	VERB
aisthesis-3151	112	7	the	the	DET
aisthesis-3151	112	8	basis	basis	NOUN
aisthesis-3151	112	9	for	for	ADP
aisthesis-3151	112	10	the	the	DET
aisthesis-3151	112	11	clinical	clinical	ADJ
aisthesis-3151	112	12	use	use	NOUN
aisthesis-3151	112	13	of	of	ADP
aisthesis-3151	112	14	targeted	target	VERB
aisthesis-3151	112	15	immunotherapies	immunotherapy	NOUN
aisthesis-3151	112	16	that	that	PRON
aisthesis-3151	112	17	would	would	AUX
aisthesis-3151	112	18	block	block	VERB
aisthesis-3151	112	19	the	the	DET
aisthesis-3151	112	20	pdl1	pdl1	NOUN
aisthesis-3151	112	21	/	/	SYM
aisthesis-3151	112	22	pd-1	pd-1	VERB
aisthesis-3151	112	23	interaction	interaction	NOUN
aisthesis-3151	112	24	,	,	PUNCT
aisthesis-3151	112	25	thereby	thereby	ADV
aisthesis-3151	112	26	stimulating	stimulate	VERB
aisthesis-3151	112	27	the	the	DET
aisthesis-3151	112	28	t	t	NOUN
aisthesis-3151	112	29	cellmediated	cellmediate	VERB
aisthesis-3151	112	30	immune	immune	ADJ
aisthesis-3151	112	31	response	response	NOUN
aisthesis-3151	112	32	against	against	ADP
aisthesis-3151	112	33	cancerous	cancerous	ADJ
aisthesis-3151	112	34	cells	cell	NOUN
aisthesis-3151	112	35	in	in	ADP
aisthesis-3151	112	36	a	a	DET
aisthesis-3151	112	37	more	more	ADV
aisthesis-3151	112	38	speci$c	speci$c	NOUN
aisthesis-3151	112	39	manner	manner	NOUN
aisthesis-3151	112	40	as	as	ADP
aisthesis-3151	112	41	compared	compare	VERB
aisthesis-3151	112	42	to	to	ADP
aisthesis-3151	112	43	previous	previous	ADJ
aisthesis-3151	112	44	cytokine	cytokine	NOUN
aisthesis-3151	112	45	immunotherapies	immunotherapy	NOUN
aisthesis-3151	112	46	.	.	PUNCT
aisthesis-3151	113	1	since	since	SCONJ
aisthesis-3151	113	2	2009	2009	NUM
aisthesis-3151	113	3	,	,	PUNCT
aisthesis-3151	113	4	two	two	NUM
aisthesis-3151	113	5	novel	novel	NOUN
aisthesis-3151	113	6	targeted	target	VERB
aisthesis-3151	113	7	immunotherapies	immunotherapy	NOUN
aisthesis-3151	113	8	have	have	AUX
aisthesis-3151	113	9	entered	enter	VERB
aisthesis-3151	113	10	clinical	clinical	ADJ
aisthesis-3151	113	11	trials	trial	NOUN
aisthesis-3151	113	12	.	.	PUNCT
aisthesis-3151	114	1	#	#	SYM
aisthesis-3151	114	2	e	e	PRON
aisthesis-3151	114	3	$	$	SYM
aisthesis-3151	114	4	rst	rst	PROPN
aisthesis-3151	114	5	is	be	AUX
aisthesis-3151	114	6	nivolumab	nivolumab	NOUN
aisthesis-3151	114	7	,	,	PUNCT
aisthesis-3151	114	8	an	an	DET
aisthesis-3151	114	9	immune	immune	ADJ
aisthesis-3151	114	10	checkpoint	checkpoint	NOUN
aisthesis-3151	114	11	inhibitor	inhibitor	NOUN
aisthesis-3151	114	12	antibody	antibody	NOUN
aisthesis-3151	114	13	that	that	PRON
aisthesis-3151	114	14	blocks	block	VERB
aisthesis-3151	114	15	the	the	DET
aisthesis-3151	114	16	programmed	program	VERB
aisthesis-3151	114	17	death-1	death-1	PROPN
aisthesis-3151	114	18	(	(	PUNCT
aisthesis-3151	114	19	pd-1	pd-1	NOUN
aisthesis-3151	114	20	)	)	PUNCT
aisthesis-3151	114	21	receptor	receptor	NOUN
aisthesis-3151	114	22	found	find	VERB
aisthesis-3151	114	23	on	on	ADP
aisthesis-3151	114	24	t	t	PROPN
aisthesis-3151	114	25	cells	cell	NOUN
aisthesis-3151	114	26	,	,	PUNCT
aisthesis-3151	114	27	thereby	thereby	ADV
aisthesis-3151	114	28	preventing	prevent	VERB
aisthesis-3151	114	29	the	the	DET
aisthesis-3151	114	30	pd-1	pd-1	ADJ
aisthesis-3151	114	31	/	/	SYM
aisthesis-3151	114	32	pdl1	pdl1	ADJ
aisthesis-3151	114	33	interaction	interaction	NOUN
aisthesis-3151	114	34	that	that	PRON
aisthesis-3151	114	35	results	result	VERB
aisthesis-3151	114	36	in	in	ADP
aisthesis-3151	114	37	death	death	NOUN
aisthesis-3151	114	38	of	of	ADP
aisthesis-3151	114	39	the	the	DET
aisthesis-3151	114	40	t	t	NOUN
aisthesis-3151	114	41	cell	cell	NOUN
aisthesis-3151	114	42	.	.	PUNCT
aisthesis-3151	115	1	#	#	SYM
aisthesis-3151	115	2	e	e	NOUN
aisthesis-3151	115	3	second	second	NOUN
aisthesis-3151	115	4	is	be	AUX
aisthesis-3151	115	5	ipilimumab	ipilimumab	ADJ
aisthesis-3151	115	6	,	,	PUNCT
aisthesis-3151	115	7	a	a	DET
aisthesis-3151	115	8	t	t	NOUN
aisthesis-3151	115	9	-	-	PUNCT
aisthesis-3151	115	10	cell	cell	NOUN
aisthesis-3151	115	11	potentiator	potentiator	NOUN
aisthesis-3151	115	12	that	that	PRON
aisthesis-3151	115	13	works	work	VERB
aisthesis-3151	115	14	by	by	ADP
aisthesis-3151	115	15	blocking	block	VERB
aisthesis-3151	115	16	cytotoxic	cytotoxic	ADJ
aisthesis-3151	115	17	t	t	PROPN
aisthesis-3151	115	18	-	-	PUNCT
aisthesis-3151	115	19	lymphocyte	lymphocyte	NOUN
aisthesis-3151	115	20	antigen-4	antigen-4	PROPN
aisthesis-3151	115	21	(	(	PUNCT
aisthesis-3151	115	22	ctla-4	ctla-4	NOUN
aisthesis-3151	115	23	)	)	PUNCT
aisthesis-3151	115	24	,	,	PUNCT
aisthesis-3151	115	25	a	a	DET
aisthesis-3151	115	26	receptor	receptor	NOUN
aisthesis-3151	115	27	on	on	ADP
aisthesis-3151	115	28	the	the	DET
aisthesis-3151	115	29	t	t	NOUN
aisthesis-3151	115	30	cell	cell	NOUN
aisthesis-3151	115	31	that	that	PRON
aisthesis-3151	115	32	inhibits	inhibit	VERB
aisthesis-3151	115	33	stimulatory	stimulatory	ADJ
aisthesis-3151	115	34	signaling	signal	VERB
aisthesis-3151	115	35	upon	upon	SCONJ
aisthesis-3151	115	36	binding	bind	VERB
aisthesis-3151	115	37	to	to	ADP
aisthesis-3151	115	38	its	its	PRON
aisthesis-3151	115	39	ligand	ligand	NOUN
aisthesis-3151	115	40	.	.	PUNCT
aisthesis-3151	116	1	e!ectively	e!ectively	ADV
aisthesis-3151	116	2	,	,	PUNCT
aisthesis-3151	116	3	both	both	DET
aisthesis-3151	116	4	therapies	therapy	NOUN
aisthesis-3151	116	5	remove	remove	VERB
aisthesis-3151	116	6	inhibitory	inhibitory	ADJ
aisthesis-3151	116	7	signals	signal	NOUN
aisthesis-3151	116	8	and	and	CCONJ
aisthesis-3151	116	9	promote	promote	VERB
aisthesis-3151	116	10	antitumor	antitumor	PROPN
aisthesis-3151	116	11	activity	activity	NOUN
aisthesis-3151	116	12	(	(	PUNCT
aisthesis-3151	116	13	figure	figure	NOUN
aisthesis-3151	116	14	5	5	NUM
aisthesis-3151	116	15	)	)	PUNCT
aisthesis-3151	116	16	.	.	PUNCT
aisthesis-3151	117	1	a	a	DET
aisthesis-3151	117	2	small	small	ADJ
aisthesis-3151	117	3	phase	phase	NOUN
aisthesis-3151	117	4	i	i	PRON
aisthesis-3151	117	5	clinical	clinical	ADJ
aisthesis-3151	117	6	trial	trial	NOUN
aisthesis-3151	117	7	showed	show	VERB
aisthesis-3151	117	8	that	that	SCONJ
aisthesis-3151	117	9	metastatic	metastatic	ADJ
aisthesis-3151	117	10	renal	renal	ADJ
aisthesis-3151	117	11	cell	cell	NOUN
aisthesis-3151	117	12	carcinoma	carcinoma	NOUN
aisthesis-3151	117	13	patients	patient	NOUN
aisthesis-3151	117	14	treated	treat	VERB
aisthesis-3151	117	15	with	with	ADP
aisthesis-3151	117	16	nivolumab	nivolumab	NOUN
aisthesis-3151	117	17	experienced	experience	VERB
aisthesis-3151	117	18	manageable	manageable	ADJ
aisthesis-3151	117	19	toxicities	toxicity	NOUN
aisthesis-3151	117	20	and	and	CCONJ
aisthesis-3151	117	21	durable	durable	ADJ
aisthesis-3151	117	22	responses	response	NOUN
aisthesis-3151	117	23	that	that	SCONJ
aisthesis-3151	117	24	,	,	PUNCT
aisthesis-3151	117	25	in	in	ADP
aisthesis-3151	117	26	some	some	DET
aisthesis-3151	117	27	cases	case	NOUN
aisthesis-3151	117	28	,	,	PUNCT
aisthesis-3151	117	29	persisted	persist	VERB
aisthesis-3151	117	30	a&er	a&er	ADJ
aisthesis-3151	117	31	drug	drug	NOUN
aisthesis-3151	117	32	discontinuation	discontinuation	NOUN
aisthesis-3151	117	33	(	(	PUNCT
aisthesis-3151	117	34	mcdermott	mcdermott	PROPN
aisthesis-3151	117	35	et	et	PROPN
aisthesis-3151	117	36	al	al	PROPN
aisthesis-3151	117	37	.	.	PROPN
aisthesis-3151	117	38	,	,	PUNCT
aisthesis-3151	117	39	2015	2015	NUM
aisthesis-3151	117	40	)	)	PUNCT
aisthesis-3151	117	41	.	.	PUNCT
aisthesis-3151	118	1	although	although	SCONJ
aisthesis-3151	118	2	not	not	PART
aisthesis-3151	118	3	used	use	VERB
aisthesis-3151	118	4	as	as	ADP
aisthesis-3151	118	5	a	a	DET
aisthesis-3151	118	6	monotherapy	monotherapy	NOUN
aisthesis-3151	118	7	for	for	ADP
aisthesis-3151	118	8	renal	renal	ADJ
aisthesis-3151	118	9	cell	cell	NOUN
aisthesis-3151	118	10	carcinoma	carcinoma	NOUN
aisthesis-3151	118	11	,	,	PUNCT
aisthesis-3151	118	12	ipilimumab	ipilimumab	NOUN
aisthesis-3151	118	13	led	lead	VERB
aisthesis-3151	118	14	to	to	ADP
aisthesis-3151	118	15	improved	improved	ADJ
aisthesis-3151	118	16	survival	survival	NOUN
aisthesis-3151	118	17	outcomes	outcome	NOUN
aisthesis-3151	118	18	as	as	SCONJ
aisthesis-3151	118	19	compared	compare	VERB
aisthesis-3151	118	20	to	to	ADP
aisthesis-3151	118	21	those	those	PRON
aisthesis-3151	118	22	treated	treat	VERB
aisthesis-3151	118	23	with	with	ADP
aisthesis-3151	118	24	standard	standard	ADJ
aisthesis-3151	118	25	-	-	PUNCT
aisthesis-3151	118	26	ofcare	ofcare	NOUN
aisthesis-3151	118	27	glycoprotein	glycoprotein	NOUN
aisthesis-3151	118	28	peptide	peptide	NOUN
aisthesis-3151	118	29	vaccine	vaccine	NOUN
aisthesis-3151	118	30	treatment	treatment	NOUN
aisthesis-3151	118	31	(	(	PUNCT
aisthesis-3151	118	32	10.0	10.0	NUM
aisthesis-3151	118	33	months	month	NOUN
aisthesis-3151	118	34	vs.	vs.	ADP
aisthesis-3151	118	35	6.4	6.4	NUM
aisthesis-3151	118	36	months	month	NOUN
aisthesis-3151	118	37	)	)	PUNCT
aisthesis-3151	118	38	in	in	ADP
aisthesis-3151	118	39	metastatic	metastatic	ADJ
aisthesis-3151	118	40	melanoma	melanoma	NOUN
aisthesis-3151	118	41	patients	patient	NOUN
aisthesis-3151	118	42	(	(	PUNCT
aisthesis-3151	118	43	hodi	hodi	X
aisthesis-3151	118	44	et	et	PROPN
aisthesis-3151	118	45	al	al	PROPN
aisthesis-3151	118	46	.	.	PROPN
aisthesis-3151	118	47	,	,	PUNCT
aisthesis-3151	118	48	2010	2010	NUM
aisthesis-3151	118	49	)	)	PUNCT
aisthesis-3151	118	50	.	.	PUNCT
aisthesis-3151	119	1	success	success	NOUN
aisthesis-3151	119	2	of	of	ADP
aisthesis-3151	119	3	both	both	PRON
aisthesis-3151	119	4	of	of	ADP
aisthesis-3151	119	5	these	these	DET
aisthesis-3151	119	6	treatments	treatment	NOUN
aisthesis-3151	119	7	as	as	SCONJ
aisthesis-3151	119	8	monotherapies	monotherapie	NOUN
aisthesis-3151	119	9	led	lead	VERB
aisthesis-3151	119	10	to	to	ADP
aisthesis-3151	119	11	the	the	DET
aisthesis-3151	119	12	hypothesis	hypothesis	NOUN
aisthesis-3151	119	13	that	that	PRON
aisthesis-3151	119	14	these	these	DET
aisthesis-3151	119	15	two	two	NUM
aisthesis-3151	119	16	drugs	drug	NOUN
aisthesis-3151	119	17	may	may	AUX
aisthesis-3151	119	18	have	have	VERB
aisthesis-3151	119	19	a	a	DET
aisthesis-3151	119	20	synergistic	synergistic	ADJ
aisthesis-3151	119	21	e!ect	e!ect	NOUN
aisthesis-3151	119	22	when	when	SCONJ
aisthesis-3151	119	23	used	use	VERB
aisthesis-3151	119	24	in	in	ADP
aisthesis-3151	119	25	combination	combination	NOUN
aisthesis-3151	119	26	(	(	PUNCT
aisthesis-3151	119	27	melero	melero	NOUN
aisthesis-3151	119	28	et	et	PROPN
aisthesis-3151	119	29	al	al	PROPN
aisthesis-3151	119	30	.	.	PROPN
aisthesis-3151	119	31	,	,	PUNCT
aisthesis-3151	119	32	2015	2015	NUM
aisthesis-3151	119	33	)	)	PUNCT
aisthesis-3151	119	34	.	.	PUNCT
aisthesis-3151	120	1	in	in	ADP
aisthesis-3151	120	2	the	the	DET
aisthesis-3151	120	3	checkmate	checkmate	NOUN
aisthesis-3151	120	4	0214	0214	NUM
aisthesis-3151	120	5	trial	trial	NOUN
aisthesis-3151	120	6	,	,	PUNCT
aisthesis-3151	120	7	a	a	DET
aisthesis-3151	120	8	phase	phase	NOUN
aisthesis-3151	120	9	iii	iii	NUM
aisthesis-3151	120	10	clinical	clinical	ADJ
aisthesis-3151	120	11	trial	trial	NOUN
aisthesis-3151	120	12	,	,	PUNCT
aisthesis-3151	120	13	approximately	approximately	ADV
aisthesis-3151	120	14	850	850	NUM
aisthesis-3151	120	15	intermediate	intermediate	ADJ
aisthesis-3151	120	16	or	or	CCONJ
aisthesis-3151	120	17	poor	poor	ADJ
aisthesis-3151	120	18	-	-	PUNCT
aisthesis-3151	120	19	risk	risk	NOUN
aisthesis-3151	120	20	renal	renal	ADJ
aisthesis-3151	120	21	cell	cell	NOUN
aisthesis-3151	120	22	carcinoma	carcinoma	NOUN
aisthesis-3151	120	23	patients	patient	NOUN
aisthesis-3151	120	24	were	be	AUX
aisthesis-3151	120	25	enrolled	enrol	VERB
aisthesis-3151	120	26	and	and	CCONJ
aisthesis-3151	120	27	figure	figure	VERB
aisthesis-3151	120	28	6	6	NUM
aisthesis-3151	120	29	:	:	PUNCT
aisthesis-3151	120	30	overall	overall	ADJ
aisthesis-3151	120	31	survival	survival	NOUN
aisthesis-3151	120	32	and	and	CCONJ
aisthesis-3151	120	33	progression	progression	NOUN
aisthesis-3151	120	34	-	-	PUNCT
aisthesis-3151	120	35	free	free	ADJ
aisthesis-3151	120	36	survival	survival	NOUN
aisthesis-3151	120	37	is	be	AUX
aisthesis-3151	120	38	greater	great	ADJ
aisthesis-3151	120	39	for	for	ADP
aisthesis-3151	120	40	patients	patient	NOUN
aisthesis-3151	120	41	treated	treat	VERB
aisthesis-3151	120	42	with	with	ADP
aisthesis-3151	120	43	nivolumab	nivolumab	NOUN
aisthesis-3151	120	44	+	+	CCONJ
aisthesis-3151	120	45	ipilimumab	ipilimumab	ADV
aisthesis-3151	120	46	than	than	ADP
aisthesis-3151	120	47	with	with	ADP
aisthesis-3151	120	48	sunitinib	sunitinib	NOUN
aisthesis-3151	120	49	.	.	PUNCT
aisthesis-3151	121	1	a	a	DET
aisthesis-3151	121	2	)	)	PUNCT
aisthesis-3151	121	3	overall	overall	ADJ
aisthesis-3151	121	4	survival	survival	NOUN
aisthesis-3151	121	5	is	be	AUX
aisthesis-3151	121	6	determined	determine	VERB
aisthesis-3151	121	7	by	by	ADP
aisthesis-3151	121	8	calculating	calculate	VERB
aisthesis-3151	121	9	percentage	percentage	NOUN
aisthesis-3151	121	10	of	of	ADP
aisthesis-3151	121	11	patients	patient	NOUN
aisthesis-3151	121	12	who	who	PRON
aisthesis-3151	121	13	have	have	AUX
aisthesis-3151	121	14	survived	survive	VERB
aisthesis-3151	121	15	at	at	ADP
aisthesis-3151	121	16	a	a	DET
aisthesis-3151	121	17	given	give	VERB
aisthesis-3151	121	18	time	time	NOUN
aisthesis-3151	121	19	point	point	NOUN
aisthesis-3151	121	20	(	(	PUNCT
aisthesis-3151	121	21	i.e	i.e	NOUN
aisthesis-3151	121	22	:	:	PUNCT
aisthesis-3151	121	23	12	12	NUM
aisthesis-3151	121	24	months	month	NOUN
aisthesis-3151	121	25	,	,	PUNCT
aisthesis-3151	121	26	as	as	SCONJ
aisthesis-3151	121	27	demarcated	demarcate	VERB
aisthesis-3151	121	28	above	above	ADV
aisthesis-3151	121	29	)	)	PUNCT
aisthesis-3151	122	1	a&er	a&er	NOUN
aisthesis-3151	122	2	initiating	initiate	VERB
aisthesis-3151	122	3	a	a	DET
aisthesis-3151	122	4	treatment	treatment	NOUN
aisthesis-3151	122	5	.	.	PUNCT
aisthesis-3151	123	1	advanced	advanced	ADJ
aisthesis-3151	123	2	renal	renal	ADJ
aisthesis-3151	123	3	cell	cell	NOUN
aisthesis-3151	123	4	carcinoma	carcinoma	NOUN
aisthesis-3151	123	5	patients	patient	NOUN
aisthesis-3151	123	6	who	who	PRON
aisthesis-3151	123	7	received	receive	VERB
aisthesis-3151	123	8	nivolumab	nivolumab	NOUN
aisthesis-3151	123	9	and	and	CCONJ
aisthesis-3151	123	10	ipilimumab	ipilimumab	NOUN
aisthesis-3151	123	11	demonstrated	demonstrate	VERB
aisthesis-3151	123	12	much	much	ADV
aisthesis-3151	123	13	higher	high	ADJ
aisthesis-3151	123	14	survival	survival	NOUN
aisthesis-3151	123	15	rates	rate	NOUN
aisthesis-3151	123	16	than	than	ADP
aisthesis-3151	123	17	those	those	PRON
aisthesis-3151	123	18	who	who	PRON
aisthesis-3151	123	19	were	be	AUX
aisthesis-3151	123	20	treated	treat	VERB
aisthesis-3151	123	21	with	with	ADP
aisthesis-3151	123	22	sunitinib	sunitinib	NOUN
aisthesis-3151	123	23	at	at	ADP
aisthesis-3151	123	24	any	any	DET
aisthesis-3151	123	25	given	give	VERB
aisthesis-3151	123	26	time	time	NOUN
aisthesis-3151	123	27	point	point	NOUN
aisthesis-3151	123	28	.	.	PUNCT
aisthesis-3151	124	1	b	b	X
aisthesis-3151	124	2	)	)	PUNCT
aisthesis-3151	124	3	progression	progression	NOUN
aisthesis-3151	124	4	-	-	PUNCT
aisthesis-3151	124	5	free	free	ADJ
aisthesis-3151	124	6	survival	survival	NOUN
aisthesis-3151	124	7	is	be	AUX
aisthesis-3151	124	8	determined	determine	VERB
aisthesis-3151	124	9	by	by	ADP
aisthesis-3151	124	10	calculating	calculate	VERB
aisthesis-3151	124	11	percentage	percentage	NOUN
aisthesis-3151	124	12	of	of	ADP
aisthesis-3151	124	13	patients	patient	NOUN
aisthesis-3151	124	14	who	who	PRON
aisthesis-3151	124	15	are	be	AUX
aisthesis-3151	124	16	not	not	PART
aisthesis-3151	124	17	only	only	ADV
aisthesis-3151	124	18	surviving	survive	VERB
aisthesis-3151	124	19	on	on	ADP
aisthesis-3151	124	20	a	a	DET
aisthesis-3151	124	21	treatment	treatment	NOUN
aisthesis-3151	124	22	,	,	PUNCT
aisthesis-3151	124	23	but	but	CCONJ
aisthesis-3151	124	24	also	also	ADV
aisthesis-3151	124	25	do	do	AUX
aisthesis-3151	124	26	not	not	PART
aisthesis-3151	124	27	demonstrate	demonstrate	VERB
aisthesis-3151	124	28	any	any	DET
aisthesis-3151	124	29	signs	sign	NOUN
aisthesis-3151	124	30	of	of	ADP
aisthesis-3151	124	31	worsening	worsen	VERB
aisthesis-3151	124	32	disease	disease	NOUN
aisthesis-3151	124	33	at	at	ADP
aisthesis-3151	124	34	a	a	DET
aisthesis-3151	124	35	given	give	VERB
aisthesis-3151	124	36	time	time	NOUN
aisthesis-3151	124	37	point	point	NOUN
aisthesis-3151	124	38	.	.	PUNCT
aisthesis-3151	125	1	advanced	advanced	ADJ
aisthesis-3151	125	2	renal	renal	ADJ
aisthesis-3151	125	3	cell	cell	NOUN
aisthesis-3151	125	4	carcinoma	carcinoma	NOUN
aisthesis-3151	125	5	patients	patient	NOUN
aisthesis-3151	125	6	who	who	PRON
aisthesis-3151	125	7	received	receive	VERB
aisthesis-3151	125	8	nivolumab	nivolumab	NOUN
aisthesis-3151	125	9	and	and	CCONJ
aisthesis-3151	125	10	ipilimumab	ipilimumab	NOUN
aisthesis-3151	125	11	demonstrated	demonstrate	VERB
aisthesis-3151	125	12	longer	long	ADJ
aisthesis-3151	125	13	progression	progression	NOUN
aisthesis-3151	125	14	-	-	PUNCT
aisthesis-3151	125	15	free	free	ADJ
aisthesis-3151	125	16	survival	survival	NOUN
aisthesis-3151	125	17	than	than	ADP
aisthesis-3151	125	18	those	those	PRON
aisthesis-3151	125	19	who	who	PRON
aisthesis-3151	125	20	were	be	AUX
aisthesis-3151	125	21	treated	treat	VERB
aisthesis-3151	125	22	with	with	ADP
aisthesis-3151	125	23	sunitinib	sunitinib	NOUN
aisthesis-3151	125	24	(	(	PUNCT
aisthesis-3151	125	25	motzer	motzer	NOUN
aisthesis-3151	125	26	et	et	PROPN
aisthesis-3151	125	27	al	al	PROPN
aisthesis-3151	125	28	.	.	PROPN
aisthesis-3151	125	29	,	,	PUNCT
aisthesis-3151	125	30	2018	2018	NUM
aisthesis-3151	125	31	)	)	PUNCT
aisthesis-3151	125	32	.	.	PUNCT
aisthesis-3151	125	33	!	!	PUNCT
aisthesis-3151	126	1	e	e	X
aisthesis-3151	126	2	past	past	NOUN
aisthesis-3151	126	3	,	,	PUNCT
aisthesis-3151	126	4	present	present	ADJ
aisthesis-3151	126	5	,	,	PUNCT
aisthesis-3151	126	6	and	and	CCONJ
aisthesis-3151	126	7	future	future	NOUN
aisthesis-3151	126	8	of	of	ADP
aisthesis-3151	126	9	renal	renal	ADJ
aisthesis-3151	126	10	cell	cell	NOUN
aisthesis-3151	126	11	carcinoma	carcinoma	NOUN
aisthesis-3151	126	12	treatment	treatment	NOUN
aisthesis-3151	126	13	aisthesis	aisthesis	NOUN
aisthesis-3151	126	14	volume	volume	NOUN
aisthesis-3151	126	15	11	11	NUM
aisthesis-3151	126	16	,	,	PUNCT
aisthesis-3151	126	17	20206	20206	NUM
aisthesis-3151	126	18	randomized	randomize	VERB
aisthesis-3151	126	19	to	to	ADP
aisthesis-3151	126	20	one	one	NUM
aisthesis-3151	126	21	of	of	ADP
aisthesis-3151	126	22	two	two	NUM
aisthesis-3151	126	23	treatment	treatment	NOUN
aisthesis-3151	126	24	arms	arm	NOUN
aisthesis-3151	126	25	:	:	PUNCT
aisthesis-3151	126	26	nivolumab	nivolumab	NOUN
aisthesis-3151	126	27	and	and	CCONJ
aisthesis-3151	126	28	ipilimumab	ipilimumab	VERB
aisthesis-3151	126	29	(	(	PUNCT
aisthesis-3151	126	30	425	425	NUM
aisthesis-3151	126	31	patients	patient	NOUN
aisthesis-3151	126	32	)	)	PUNCT
aisthesis-3151	126	33	,	,	PUNCT
aisthesis-3151	126	34	or	or	CCONJ
aisthesis-3151	126	35	sunitinib	sunitinib	NOUN
aisthesis-3151	126	36	(	(	PUNCT
aisthesis-3151	126	37	422	422	NUM
aisthesis-3151	126	38	patients	patient	NOUN
aisthesis-3151	126	39	)	)	PUNCT
aisthesis-3151	126	40	(	(	PUNCT
aisthesis-3151	126	41	motzer	motzer	NOUN
aisthesis-3151	126	42	et	et	PROPN
aisthesis-3151	126	43	al	al	PROPN
aisthesis-3151	126	44	.	.	PROPN
aisthesis-3151	126	45	,	,	PUNCT
aisthesis-3151	126	46	2018	2018	NUM
aisthesis-3151	126	47	)	)	PUNCT
aisthesis-3151	126	48	.	.	PUNCT
aisthesis-3151	127	1	researchers	researcher	NOUN
aisthesis-3151	127	2	followed	follow	VERB
aisthesis-3151	127	3	up	up	ADP
aisthesis-3151	127	4	with	with	ADP
aisthesis-3151	127	5	these	these	DET
aisthesis-3151	127	6	patients	patient	NOUN
aisthesis-3151	127	7	to	to	PART
aisthesis-3151	127	8	track	track	VERB
aisthesis-3151	127	9	overall	overall	ADJ
aisthesis-3151	127	10	survival	survival	NOUN
aisthesis-3151	127	11	and	and	CCONJ
aisthesis-3151	127	12	progression	progression	NOUN
aisthesis-3151	127	13	-	-	PUNCT
aisthesis-3151	127	14	free	free	ADJ
aisthesis-3151	127	15	survival	survival	NOUN
aisthesis-3151	127	16	to	to	PART
aisthesis-3151	127	17	compare	compare	VERB
aisthesis-3151	127	18	the	the	DET
aisthesis-3151	127	19	e(cacies	e(cacie	NOUN
aisthesis-3151	127	20	of	of	ADP
aisthesis-3151	127	21	the	the	DET
aisthesis-3151	127	22	di!erent	di!erent	NOUN
aisthesis-3151	127	23	treatment	treatment	NOUN
aisthesis-3151	127	24	arms	arm	NOUN
aisthesis-3151	127	25	.	.	PUNCT
aisthesis-3151	128	1	it	it	PRON
aisthesis-3151	128	2	was	be	AUX
aisthesis-3151	128	3	observed	observe	VERB
aisthesis-3151	128	4	that	that	SCONJ
aisthesis-3151	128	5	patients	patient	NOUN
aisthesis-3151	128	6	on	on	ADP
aisthesis-3151	128	7	the	the	DET
aisthesis-3151	128	8	nivolumab	nivolumab	NOUN
aisthesis-3151	128	9	+	+	CCONJ
aisthesis-3151	128	10	ipilimumab	ipilimumab	ADJ
aisthesis-3151	128	11	arm	arm	NOUN
aisthesis-3151	128	12	had	have	VERB
aisthesis-3151	128	13	superior	superior	ADJ
aisthesis-3151	128	14	survival	survival	NOUN
aisthesis-3151	128	15	outcomes	outcome	NOUN
aisthesis-3151	128	16	than	than	ADP
aisthesis-3151	128	17	patients	patient	NOUN
aisthesis-3151	128	18	on	on	ADP
aisthesis-3151	128	19	the	the	DET
aisthesis-3151	128	20	sunitinib	sunitinib	NOUN
aisthesis-3151	128	21	arm	arm	NOUN
aisthesis-3151	128	22	(	(	PUNCT
aisthesis-3151	128	23	figure	figure	NOUN
aisthesis-3151	128	24	6	6	NUM
aisthesis-3151	128	25	)	)	PUNCT
aisthesis-3151	128	26	.	.	PUNCT
aisthesis-3151	129	1	patients	patient	NOUN
aisthesis-3151	129	2	treated	treat	VERB
aisthesis-3151	129	3	with	with	ADP
aisthesis-3151	129	4	the	the	DET
aisthesis-3151	129	5	nivolumab	nivolumab	NOUN
aisthesis-3151	129	6	+	+	CCONJ
aisthesis-3151	129	7	ipilimumab	ipilimumab	NOUN
aisthesis-3151	129	8	combination	combination	NOUN
aisthesis-3151	129	9	had	have	VERB
aisthesis-3151	129	10	a	a	DET
aisthesis-3151	129	11	greater	great	ADJ
aisthesis-3151	129	12	duration	duration	NOUN
aisthesis-3151	129	13	of	of	ADP
aisthesis-3151	129	14	overall	overall	ADJ
aisthesis-3151	129	15	survival	survival	NOUN
aisthesis-3151	129	16	(	(	PUNCT
aisthesis-3151	129	17	not	not	PART
aisthesis-3151	129	18	reached	reach	VERB
aisthesis-3151	129	19	vs.	vs.	ADP
aisthesis-3151	129	20	26.0	26.0	NUM
aisthesis-3151	129	21	months	month	NOUN
aisthesis-3151	129	22	,	,	PUNCT
aisthesis-3151	129	23	respectively	respectively	ADV
aisthesis-3151	129	24	)	)	PUNCT
aisthesis-3151	129	25	and	and	CCONJ
aisthesis-3151	129	26	progression	progression	NOUN
aisthesis-3151	129	27	-	-	PUNCT
aisthesis-3151	129	28	free	free	ADJ
aisthesis-3151	129	29	survival	survival	NOUN
aisthesis-3151	129	30	(	(	PUNCT
aisthesis-3151	129	31	11.6	11.6	NUM
aisthesis-3151	129	32	months	month	NOUN
aisthesis-3151	129	33	vs.	vs.	ADP
aisthesis-3151	129	34	8.4	8.4	NUM
aisthesis-3151	129	35	months	month	NOUN
aisthesis-3151	129	36	)	)	PUNCT
aisthesis-3151	129	37	than	than	ADP
aisthesis-3151	129	38	those	those	PRON
aisthesis-3151	129	39	treated	treat	VERB
aisthesis-3151	129	40	with	with	ADP
aisthesis-3151	129	41	sunitinib	sunitinib	NOUN
aisthesis-3151	129	42	.	.	PUNCT
aisthesis-3151	130	1	cardiovascular	cardiovascular	ADJ
aisthesis-3151	130	2	toxicities	toxicity	NOUN
aisthesis-3151	130	3	and	and	CCONJ
aisthesis-3151	130	4	other	other	ADJ
aisthesis-3151	130	5	severe	severe	ADJ
aisthesis-3151	130	6	adverse	adverse	ADJ
aisthesis-3151	130	7	events	event	NOUN
aisthesis-3151	130	8	were	be	AUX
aisthesis-3151	130	9	signi$cantly	signi$cantly	ADV
aisthesis-3151	130	10	lower	low	ADJ
aisthesis-3151	130	11	for	for	ADP
aisthesis-3151	130	12	the	the	DET
aisthesis-3151	130	13	nivolumab	nivolumab	NOUN
aisthesis-3151	130	14	+	+	CCONJ
aisthesis-3151	130	15	ipilimumab	ipilimumab	ADJ
aisthesis-3151	130	16	arm	arm	NOUN
aisthesis-3151	130	17	as	as	SCONJ
aisthesis-3151	130	18	compared	compare	VERB
aisthesis-3151	130	19	to	to	ADP
aisthesis-3151	130	20	the	the	DET
aisthesis-3151	130	21	sunitinib	sunitinib	NOUN
aisthesis-3151	130	22	arm	arm	VERB
aisthesis-3151	130	23	.	.	PUNCT
aisthesis-3151	131	1	#	#	SYM
aisthesis-3151	131	2	ese	ese	NOUN
aisthesis-3151	131	3	$	$	SYM
aisthesis-3151	131	4	ndings	nding	NOUN
aisthesis-3151	131	5	provide	provide	VERB
aisthesis-3151	131	6	support	support	NOUN
aisthesis-3151	131	7	for	for	ADP
aisthesis-3151	131	8	the	the	DET
aisthesis-3151	131	9	use	use	NOUN
aisthesis-3151	131	10	of	of	ADP
aisthesis-3151	131	11	nivolumab	nivolumab	NOUN
aisthesis-3151	131	12	and	and	CCONJ
aisthesis-3151	131	13	ipilimumab	ipilimumab	VERB
aisthesis-3151	131	14	as	as	ADP
aisthesis-3151	131	15	a	a	DET
aisthesis-3151	131	16	$	$	SYM
aisthesis-3151	131	17	rst	rst	NOUN
aisthesis-3151	131	18	-	-	PUNCT
aisthesis-3151	131	19	line	line	NOUN
aisthesis-3151	131	20	of	of	ADP
aisthesis-3151	131	21	therapy	therapy	NOUN
aisthesis-3151	131	22	for	for	ADP
aisthesis-3151	131	23	metastatic	metastatic	ADJ
aisthesis-3151	131	24	renal	renal	ADJ
aisthesis-3151	131	25	cell	cell	NOUN
aisthesis-3151	131	26	carcinoma	carcinoma	NOUN
aisthesis-3151	131	27	.	.	PUNCT
aisthesis-3151	132	1	#	#	SYM
aisthesis-3151	132	2	e	e	NOUN
aisthesis-3151	132	3	phase	phase	NOUN
aisthesis-3151	132	4	iii	iii	NUM
aisthesis-3151	132	5	trial	trial	NOUN
aisthesis-3151	132	6	led	lead	VERB
aisthesis-3151	132	7	by	by	ADP
aisthesis-3151	132	8	motzer	motzer	NOUN
aisthesis-3151	132	9	et	et	PROPN
aisthesis-3151	132	10	al	al	PROPN
aisthesis-3151	132	11	.	.	PROPN
aisthesis-3151	132	12	has	have	AUX
aisthesis-3151	132	13	helped	help	VERB
aisthesis-3151	132	14	establish	establish	VERB
aisthesis-3151	132	15	combination	combination	NOUN
aisthesis-3151	132	16	immunotherapy	immunotherapy	NOUN
aisthesis-3151	132	17	as	as	ADP
aisthesis-3151	132	18	a	a	DET
aisthesis-3151	132	19	new	new	ADJ
aisthesis-3151	132	20	approach	approach	NOUN
aisthesis-3151	132	21	to	to	ADP
aisthesis-3151	132	22	treating	treat	VERB
aisthesis-3151	132	23	renal	renal	ADJ
aisthesis-3151	132	24	cell	cell	NOUN
aisthesis-3151	132	25	carcinoma	carcinoma	NOUN
aisthesis-3151	132	26	.	.	PUNCT
aisthesis-3151	133	1	stimulating	stimulate	VERB
aisthesis-3151	133	2	the	the	DET
aisthesis-3151	133	3	immune	immune	ADJ
aisthesis-3151	133	4	system	system	NOUN
aisthesis-3151	133	5	more	more	ADV
aisthesis-3151	133	6	speci$cally	speci$cally	ADV
aisthesis-3151	133	7	than	than	SCONJ
aisthesis-3151	133	8	previous	previous	ADJ
aisthesis-3151	133	9	cytokine	cytokine	NOUN
aisthesis-3151	133	10	immunotherapies	immunotherapy	NOUN
aisthesis-3151	133	11	has	have	AUX
aisthesis-3151	133	12	reduced	reduce	VERB
aisthesis-3151	133	13	many	many	ADJ
aisthesis-3151	133	14	of	of	ADP
aisthesis-3151	133	15	the	the	DET
aisthesis-3151	133	16	side	side	NOUN
aisthesis-3151	133	17	e!ects	e!ects	PUNCT
aisthesis-3151	133	18	previously	previously	ADV
aisthesis-3151	133	19	observed	observe	VERB
aisthesis-3151	133	20	with	with	ADP
aisthesis-3151	133	21	cytokine	cytokine	ADJ
aisthesis-3151	133	22	immunotherapies	immunotherapy	NOUN
aisthesis-3151	133	23	,	,	PUNCT
aisthesis-3151	133	24	which	which	PRON
aisthesis-3151	133	25	induce	induce	VERB
aisthesis-3151	133	26	extensive	extensive	ADJ
aisthesis-3151	133	27	activation	activation	NOUN
aisthesis-3151	133	28	of	of	ADP
aisthesis-3151	133	29	the	the	DET
aisthesis-3151	133	30	immune	immune	ADJ
aisthesis-3151	133	31	system	system	NOUN
aisthesis-3151	133	32	.	.	PUNCT
aisthesis-3151	134	1	current	current	ADJ
aisthesis-3151	134	2	e!orts	e!ort	NOUN
aisthesis-3151	134	3	are	be	AUX
aisthesis-3151	134	4	geared	gear	VERB
aisthesis-3151	134	5	toward	toward	ADP
aisthesis-3151	134	6	evaluating	evaluate	VERB
aisthesis-3151	134	7	the	the	DET
aisthesis-3151	134	8	implications	implication	NOUN
aisthesis-3151	134	9	of	of	ADP
aisthesis-3151	134	10	treatment	treatment	NOUN
aisthesis-3151	134	11	regimens	regimen	NOUN
aisthesis-3151	134	12	,	,	PUNCT
aisthesis-3151	134	13	which	which	PRON
aisthesis-3151	134	14	include	include	VERB
aisthesis-3151	134	15	a	a	DET
aisthesis-3151	134	16	combination	combination	NOUN
aisthesis-3151	134	17	of	of	ADP
aisthesis-3151	134	18	targeted	target	VERB
aisthesis-3151	134	19	immunotherapies	immunotherapy	NOUN
aisthesis-3151	134	20	and	and	CCONJ
aisthesis-3151	134	21	vegf	vegf	PROPN
aisthesis-3151	134	22	-	-	PUNCT
aisthesis-3151	134	23	tkis	tkis	PROPN
aisthesis-3151	134	24	to	to	PART
aisthesis-3151	134	25	assess	assess	VERB
aisthesis-3151	134	26	whether	whether	SCONJ
aisthesis-3151	134	27	cross	cros	NOUN
aisthesis-3151	134	28	-	-	NOUN
aisthesis-3151	134	29	talk	talk	NOUN
aisthesis-3151	134	30	between	between	ADP
aisthesis-3151	134	31	the	the	DET
aisthesis-3151	134	32	drug	drug	NOUN
aisthesis-3151	134	33	actions	action	NOUN
aisthesis-3151	134	34	may	may	AUX
aisthesis-3151	134	35	modulate	modulate	VERB
aisthesis-3151	134	36	toxicities	toxicity	NOUN
aisthesis-3151	134	37	previously	previously	ADV
aisthesis-3151	134	38	observed	observe	VERB
aisthesis-3151	134	39	with	with	ADP
aisthesis-3151	134	40	vegf	vegf	PROPN
aisthesis-3151	134	41	-	-	PUNCT
aisthesis-3151	134	42	tkis	tkis	PROPN
aisthesis-3151	134	43	(	(	PUNCT
aisthesis-3151	134	44	national	national	PROPN
aisthesis-3151	134	45	cancer	cancer	PROPN
aisthesis-3151	134	46	institute	institute	PROPN
aisthesis-3151	134	47	,	,	PUNCT
aisthesis-3151	134	48	2018	2018	NUM
aisthesis-3151	134	49	)	)	PUNCT
aisthesis-3151	134	50	.	.	PUNCT
aisthesis-3151	135	1	additionally	additionally	ADV
aisthesis-3151	135	2	,	,	PUNCT
aisthesis-3151	135	3	in	in	ADP
aisthesis-3151	135	4	an	an	DET
aisthesis-3151	135	5	attempt	attempt	NOUN
aisthesis-3151	135	6	to	to	PART
aisthesis-3151	135	7	develop	develop	VERB
aisthesis-3151	135	8	personalized	personalized	ADJ
aisthesis-3151	135	9	treatment	treatment	NOUN
aisthesis-3151	135	10	regimens	regimen	NOUN
aisthesis-3151	135	11	,	,	PUNCT
aisthesis-3151	135	12	researchers	researcher	NOUN
aisthesis-3151	135	13	are	be	AUX
aisthesis-3151	135	14	exploring	explore	VERB
aisthesis-3151	135	15	gene	gene	NOUN
aisthesis-3151	135	16	expression	expression	NOUN
aisthesis-3151	135	17	levels	level	NOUN
aisthesis-3151	135	18	,	,	PUNCT
aisthesis-3151	135	19	primarily	primarily	ADV
aisthesis-3151	135	20	of	of	ADP
aisthesis-3151	135	21	proteins	protein	NOUN
aisthesis-3151	135	22	found	find	VERB
aisthesis-3151	135	23	in	in	ADP
aisthesis-3151	135	24	the	the	DET
aisthesis-3151	135	25	tumor	tumor	NOUN
aisthesis-3151	135	26	microenvironment	microenvironment	NOUN
aisthesis-3151	135	27	that	that	PRON
aisthesis-3151	135	28	may	may	AUX
aisthesis-3151	135	29	be	be	AUX
aisthesis-3151	135	30	predictive	predictive	ADJ
aisthesis-3151	135	31	of	of	ADP
aisthesis-3151	135	32	adverse	adverse	ADJ
aisthesis-3151	135	33	or	or	CCONJ
aisthesis-3151	135	34	positive	positive	ADJ
aisthesis-3151	135	35	responses	response	NOUN
aisthesis-3151	135	36	to	to	ADP
aisthesis-3151	135	37	immune	immune	ADJ
aisthesis-3151	135	38	checkpoint	checkpoint	NOUN
aisthesis-3151	135	39	inhibitors	inhibitor	NOUN
aisthesis-3151	135	40	(	(	PUNCT
aisthesis-3151	135	41	zhu	zhu	X
aisthesis-3151	135	42	et	et	PROPN
aisthesis-3151	135	43	al	al	PROPN
aisthesis-3151	135	44	.	.	PROPN
aisthesis-3151	135	45	,	,	PUNCT
aisthesis-3151	135	46	2019	2019	NUM
aisthesis-3151	135	47	)	)	PUNCT
aisthesis-3151	135	48	.	.	PUNCT
aisthesis-3151	136	1	conclusion	conclusion	NOUN
aisthesis-3151	136	2	over	over	ADP
aisthesis-3151	136	3	the	the	DET
aisthesis-3151	136	4	last	last	ADJ
aisthesis-3151	136	5	thirty	thirty	NUM
aisthesis-3151	136	6	years	year	NOUN
aisthesis-3151	136	7	,	,	PUNCT
aisthesis-3151	136	8	our	our	PRON
aisthesis-3151	136	9	ability	ability	NOUN
aisthesis-3151	136	10	to	to	PART
aisthesis-3151	136	11	treat	treat	VERB
aisthesis-3151	136	12	patients	patient	NOUN
aisthesis-3151	136	13	with	with	ADP
aisthesis-3151	136	14	advanced	advanced	ADJ
aisthesis-3151	136	15	renal	renal	ADJ
aisthesis-3151	136	16	cell	cell	NOUN
aisthesis-3151	136	17	carcinoma	carcinoma	NOUN
aisthesis-3151	136	18	has	have	AUX
aisthesis-3151	136	19	greatly	greatly	ADV
aisthesis-3151	136	20	improved	improve	VERB
aisthesis-3151	136	21	.	.	PUNCT
aisthesis-3151	137	1	whereas	whereas	SCONJ
aisthesis-3151	137	2	nephrectomy	nephrectomy	ADV
aisthesis-3151	137	3	and/	and/	NOUN
aisthesis-3151	137	4	or	or	CCONJ
aisthesis-3151	137	5	radiation	radiation	NOUN
aisthesis-3151	137	6	were	be	AUX
aisthesis-3151	137	7	once	once	ADV
aisthesis-3151	137	8	the	the	DET
aisthesis-3151	137	9	only	only	ADJ
aisthesis-3151	137	10	options	option	NOUN
aisthesis-3151	137	11	available	available	ADJ
aisthesis-3151	137	12	and	and	CCONJ
aisthesis-3151	137	13	were	be	AUX
aisthesis-3151	137	14	only	only	ADV
aisthesis-3151	137	15	su(cient	su(cient	ADJ
aisthesis-3151	137	16	to	to	PART
aisthesis-3151	137	17	eradicate	eradicate	VERB
aisthesis-3151	137	18	the	the	DET
aisthesis-3151	137	19	cancer	cancer	NOUN
aisthesis-3151	137	20	if	if	SCONJ
aisthesis-3151	137	21	detected	detect	VERB
aisthesis-3151	137	22	early	early	ADV
aisthesis-3151	137	23	enough	enough	ADV
aisthesis-3151	137	24	,	,	PUNCT
aisthesis-3151	137	25	it	it	PRON
aisthesis-3151	137	26	soon	soon	ADV
aisthesis-3151	137	27	became	become	VERB
aisthesis-3151	137	28	clear	clear	ADJ
aisthesis-3151	137	29	that	that	SCONJ
aisthesis-3151	137	30	the	the	DET
aisthesis-3151	137	31	use	use	NOUN
aisthesis-3151	137	32	of	of	ADP
aisthesis-3151	137	33	pharmacological	pharmacological	ADJ
aisthesis-3151	137	34	agents	agent	NOUN
aisthesis-3151	137	35	would	would	AUX
aisthesis-3151	137	36	be	be	AUX
aisthesis-3151	137	37	needed	need	VERB
aisthesis-3151	137	38	to	to	PART
aisthesis-3151	137	39	manage	manage	VERB
aisthesis-3151	137	40	more	more	ADV
aisthesis-3151	137	41	aggressive	aggressive	ADJ
aisthesis-3151	137	42	renal	renal	ADJ
aisthesis-3151	137	43	cell	cell	NOUN
aisthesis-3151	137	44	carcinoma	carcinoma	NOUN
aisthesis-3151	137	45	.	.	PUNCT
aisthesis-3151	138	1	#	#	SYM
aisthesis-3151	138	2	e	e	NOUN
aisthesis-3151	138	3	1990s	1990	NOUN
aisthesis-3151	138	4	saw	see	VERB
aisthesis-3151	138	5	an	an	DET
aisthesis-3151	138	6	upsurge	upsurge	NOUN
aisthesis-3151	138	7	in	in	ADP
aisthesis-3151	138	8	the	the	DET
aisthesis-3151	138	9	use	use	NOUN
aisthesis-3151	138	10	of	of	ADP
aisthesis-3151	138	11	cytokine	cytokine	ADJ
aisthesis-3151	138	12	immunotherapies	immunotherapy	NOUN
aisthesis-3151	138	13	,	,	PUNCT
aisthesis-3151	138	14	such	such	ADJ
aisthesis-3151	138	15	as	as	ADP
aisthesis-3151	138	16	hd	hd	NOUN
aisthesis-3151	138	17	-	-	NOUN
aisthesis-3151	138	18	il2	il2	NOUN
aisthesis-3151	138	19	and	and	CCONJ
aisthesis-3151	138	20	ifn-	ifn-	X
aisthesis-3151	138	21	'	'	PUNCT
aisthesis-3151	138	22	,	,	PUNCT
aisthesis-3151	138	23	which	which	PRON
aisthesis-3151	138	24	activated	activate	VERB
aisthesis-3151	138	25	various	various	ADJ
aisthesis-3151	138	26	cells	cell	NOUN
aisthesis-3151	138	27	of	of	ADP
aisthesis-3151	138	28	the	the	DET
aisthesis-3151	138	29	human	human	ADJ
aisthesis-3151	138	30	immune	immune	ADJ
aisthesis-3151	138	31	system	system	NOUN
aisthesis-3151	138	32	.	.	PUNCT
aisthesis-3151	139	1	despite	despite	SCONJ
aisthesis-3151	139	2	improving	improve	VERB
aisthesis-3151	139	3	survival	survival	NOUN
aisthesis-3151	139	4	of	of	ADP
aisthesis-3151	139	5	metastatic	metastatic	ADJ
aisthesis-3151	139	6	renal	renal	ADJ
aisthesis-3151	139	7	cell	cell	NOUN
aisthesis-3151	139	8	carcinoma	carcinoma	NOUN
aisthesis-3151	139	9	patients	patient	NOUN
aisthesis-3151	139	10	,	,	PUNCT
aisthesis-3151	139	11	treatment	treatment	NOUN
aisthesis-3151	139	12	with	with	ADP
aisthesis-3151	139	13	hdil2	hdil2	NOUN
aisthesis-3151	139	14	and/or	and/or	CCONJ
aisthesis-3151	139	15	ifn-	ifn-	X
aisthesis-3151	139	16	'	'	PUNCT
aisthesis-3151	139	17	o&en	o&en	ADV
aisthesis-3151	139	18	led	lead	VERB
aisthesis-3151	139	19	to	to	ADP
aisthesis-3151	139	20	severe	severe	ADJ
aisthesis-3151	139	21	side	side	NOUN
aisthesis-3151	139	22	e!ects	e!ects	PUNCT
aisthesis-3151	139	23	as	as	ADP
aisthesis-3151	139	24	a	a	DET
aisthesis-3151	139	25	result	result	NOUN
aisthesis-3151	139	26	of	of	ADP
aisthesis-3151	139	27	an	an	DET
aisthesis-3151	139	28	overactive	overactive	ADJ
aisthesis-3151	139	29	immune	immune	ADJ
aisthesis-3151	139	30	system	system	NOUN
aisthesis-3151	139	31	.	.	PUNCT
aisthesis-3151	140	1	upon	upon	SCONJ
aisthesis-3151	140	2	elucidation	elucidation	NOUN
aisthesis-3151	140	3	of	of	ADP
aisthesis-3151	140	4	key	key	ADJ
aisthesis-3151	140	5	molecular	molecular	ADJ
aisthesis-3151	140	6	pathways	pathway	NOUN
aisthesis-3151	140	7	involved	involve	VERB
aisthesis-3151	140	8	in	in	ADP
aisthesis-3151	140	9	the	the	DET
aisthesis-3151	140	10	onset	onset	NOUN
aisthesis-3151	140	11	and	and	CCONJ
aisthesis-3151	140	12	progression	progression	NOUN
aisthesis-3151	140	13	of	of	ADP
aisthesis-3151	140	14	renal	renal	ADJ
aisthesis-3151	140	15	cell	cell	NOUN
aisthesis-3151	140	16	carcinoma	carcinoma	NOUN
aisthesis-3151	140	17	,	,	PUNCT
aisthesis-3151	140	18	the	the	DET
aisthesis-3151	140	19	early	early	ADJ
aisthesis-3151	140	20	2000s	2000s	NUM
aisthesis-3151	140	21	were	be	AUX
aisthesis-3151	140	22	characterized	characterize	VERB
aisthesis-3151	140	23	by	by	ADP
aisthesis-3151	140	24	the	the	DET
aisthesis-3151	140	25	use	use	NOUN
aisthesis-3151	140	26	of	of	ADP
aisthesis-3151	140	27	pathway	pathway	NOUN
aisthesis-3151	140	28	-	-	PUNCT
aisthesis-3151	140	29	speci$c	speci$c	NOUN
aisthesis-3151	140	30	vegf	vegf	PROPN
aisthesis-3151	140	31	-	-	PUNCT
aisthesis-3151	140	32	tkis	tkis	PROPN
aisthesis-3151	140	33	such	such	ADJ
aisthesis-3151	140	34	as	as	ADP
aisthesis-3151	140	35	sunitinib	sunitinib	NOUN
aisthesis-3151	140	36	.	.	PUNCT
aisthesis-3151	141	1	#	#	NOUN
aisthesis-3151	141	2	ese	ese	NOUN
aisthesis-3151	141	3	drugs	drug	NOUN
aisthesis-3151	141	4	prevented	prevent	VERB
aisthesis-3151	141	5	cancer	cancer	NOUN
aisthesis-3151	141	6	cells	cell	NOUN
aisthesis-3151	141	7	from	from	ADP
aisthesis-3151	141	8	receiving	receive	VERB
aisthesis-3151	141	9	nutrients	nutrient	NOUN
aisthesis-3151	141	10	from	from	ADP
aisthesis-3151	141	11	the	the	DET
aisthesis-3151	141	12	blood	blood	NOUN
aisthesis-3151	141	13	supply	supply	NOUN
aisthesis-3151	141	14	,	,	PUNCT
aisthesis-3151	141	15	but	but	CCONJ
aisthesis-3151	141	16	also	also	ADV
aisthesis-3151	141	17	adversely	adversely	ADV
aisthesis-3151	141	18	a!ected	a!ecte	VERB
aisthesis-3151	141	19	healthy	healthy	ADJ
aisthesis-3151	141	20	cells	cell	NOUN
aisthesis-3151	141	21	,	,	PUNCT
aisthesis-3151	141	22	given	give	VERB
aisthesis-3151	141	23	that	that	SCONJ
aisthesis-3151	141	24	both	both	PRON
aisthesis-3151	141	25	use	use	VERB
aisthesis-3151	141	26	the	the	PRON
aisthesis-3151	141	27	!	!	PUNCT
aisthesis-3151	142	1	e	e	X
aisthesis-3151	142	2	past	past	NOUN
aisthesis-3151	142	3	,	,	PUNCT
aisthesis-3151	142	4	present	present	ADJ
aisthesis-3151	142	5	,	,	PUNCT
aisthesis-3151	142	6	and	and	CCONJ
aisthesis-3151	142	7	future	future	NOUN
aisthesis-3151	142	8	of	of	ADP
aisthesis-3151	142	9	renal	renal	ADJ
aisthesis-3151	142	10	cell	cell	NOUN
aisthesis-3151	142	11	carcinoma	carcinoma	NOUN
aisthesis-3151	142	12	treatment	treatment	NOUN
aisthesis-3151	142	13	aisthesis	aisthesis	NOUN
aisthesis-3151	142	14	volume	volume	NOUN
aisthesis-3151	142	15	11	11	NUM
aisthesis-3151	142	16	,	,	PUNCT
aisthesis-3151	142	17	2020	2020	NUM
aisthesis-3151	142	18	same	same	ADJ
aisthesis-3151	142	19	angiogenesis	angiogenesis	NOUN
aisthesis-3151	142	20	pathway	pathway	NOUN
aisthesis-3151	142	21	.	.	PUNCT
aisthesis-3151	143	1	nevertheless	nevertheless	ADV
aisthesis-3151	143	2	,	,	PUNCT
aisthesis-3151	143	3	the	the	DET
aisthesis-3151	143	4	survival	survival	NOUN
aisthesis-3151	143	5	rates	rate	NOUN
aisthesis-3151	143	6	were	be	AUX
aisthesis-3151	143	7	unequivocally	unequivocally	ADV
aisthesis-3151	143	8	superior	superior	ADJ
aisthesis-3151	143	9	to	to	ADP
aisthesis-3151	143	10	those	those	PRON
aisthesis-3151	143	11	observed	observe	VERB
aisthesis-3151	143	12	in	in	ADP
aisthesis-3151	143	13	cytokine	cytokine	NOUN
aisthesis-3151	143	14	immunotherapies	immunotherapy	NOUN
aisthesis-3151	143	15	,	,	PUNCT
aisthesis-3151	143	16	which	which	PRON
aisthesis-3151	143	17	led	lead	VERB
aisthesis-3151	143	18	to	to	ADP
aisthesis-3151	143	19	the	the	DET
aisthesis-3151	143	20	fda	fda	PROPN
aisthesis-3151	143	21	-	-	PUNCT
aisthesis-3151	143	22	approval	approval	NOUN
aisthesis-3151	143	23	of	of	ADP
aisthesis-3151	143	24	vegf	vegf	PROPN
aisthesis-3151	143	25	-	-	PUNCT
aisthesis-3151	143	26	tkis	tkis	PROPN
aisthesis-3151	143	27	as	as	ADP
aisthesis-3151	143	28	a	a	DET
aisthesis-3151	143	29	$	$	SYM
aisthesis-3151	143	30	rst	rst	NOUN
aisthesis-3151	143	31	line	line	NOUN
aisthesis-3151	143	32	of	of	ADP
aisthesis-3151	143	33	treatment	treatment	NOUN
aisthesis-3151	143	34	in	in	ADP
aisthesis-3151	143	35	the	the	DET
aisthesis-3151	143	36	post	post	ADJ
aisthesis-3151	143	37	-	-	ADJ
aisthesis-3151	143	38	surgical	surgical	ADJ
aisthesis-3151	143	39	and	and	CCONJ
aisthesis-3151	143	40	radiation	radiation	NOUN
aisthesis-3151	143	41	setting	setting	NOUN
aisthesis-3151	143	42	.	.	PUNCT
aisthesis-3151	144	1	recent	recent	ADJ
aisthesis-3151	144	2	pharmacological	pharmacological	ADJ
aisthesis-3151	144	3	research	research	NOUN
aisthesis-3151	144	4	has	have	AUX
aisthesis-3151	144	5	applied	apply	VERB
aisthesis-3151	144	6	the	the	DET
aisthesis-3151	144	7	concept	concept	NOUN
aisthesis-3151	144	8	of	of	ADP
aisthesis-3151	144	9	pathway	pathway	NOUN
aisthesis-3151	144	10	-	-	PUNCT
aisthesis-3151	144	11	speci$c	speci$c	NOUN
aisthesis-3151	144	12	cancer	cancer	NOUN
aisthesis-3151	144	13	therapies	therapy	NOUN
aisthesis-3151	144	14	in	in	ADP
aisthesis-3151	144	15	developing	develop	VERB
aisthesis-3151	144	16	targeted	target	VERB
aisthesis-3151	144	17	immunotherapies	immunotherapy	NOUN
aisthesis-3151	144	18	(	(	PUNCT
aisthesis-3151	144	19	nivolumab	nivolumab	NOUN
aisthesis-3151	144	20	and	and	CCONJ
aisthesis-3151	144	21	ipilimumab	ipilimumab	VERB
aisthesis-3151	144	22	)	)	PUNCT
aisthesis-3151	144	23	since	since	SCONJ
aisthesis-3151	144	24	the	the	DET
aisthesis-3151	144	25	late	late	ADJ
aisthesis-3151	144	26	2000s	2000s	NUM
aisthesis-3151	144	27	.	.	PUNCT
aisthesis-3151	145	1	targeted	target	VERB
aisthesis-3151	145	2	immunotherapies	immunotherapy	NOUN
aisthesis-3151	145	3	are	be	AUX
aisthesis-3151	145	4	devoted	devote	VERB
aisthesis-3151	145	5	to	to	ADP
aisthesis-3151	145	6	activating	activate	VERB
aisthesis-3151	145	7	the	the	DET
aisthesis-3151	145	8	patient	patient	NOUN
aisthesis-3151	145	9	’s	’s	PART
aisthesis-3151	145	10	immune	immune	ADJ
aisthesis-3151	145	11	system	system	NOUN
aisthesis-3151	145	12	in	in	ADP
aisthesis-3151	145	13	a	a	DET
aisthesis-3151	145	14	more	more	ADV
aisthesis-3151	145	15	speci$c	speci$c	NOUN
aisthesis-3151	145	16	manner	manner	NOUN
aisthesis-3151	145	17	(	(	PUNCT
aisthesis-3151	145	18	as	as	SCONJ
aisthesis-3151	145	19	compared	compare	VERB
aisthesis-3151	145	20	to	to	PART
aisthesis-3151	145	21	cytokine	cytokine	VERB
aisthesis-3151	145	22	immunotherapies	immunotherapy	NOUN
aisthesis-3151	145	23	)	)	PUNCT
aisthesis-3151	145	24	by	by	ADP
aisthesis-3151	145	25	blocking	block	VERB
aisthesis-3151	145	26	the	the	DET
aisthesis-3151	145	27	pd-1	pd-1	NOUN
aisthesis-3151	145	28	/	/	SYM
aisthesis-3151	145	29	pd	pd	ADJ
aisthesis-3151	145	30	-	-	PUNCT
aisthesis-3151	145	31	l1	l1	PROPN
aisthesis-3151	145	32	interaction	interaction	NOUN
aisthesis-3151	145	33	that	that	PRON
aisthesis-3151	145	34	inhibits	inhibit	VERB
aisthesis-3151	145	35	the	the	DET
aisthesis-3151	145	36	immune	immune	ADJ
aisthesis-3151	145	37	response	response	NOUN
aisthesis-3151	145	38	against	against	ADP
aisthesis-3151	145	39	cancer	cancer	NOUN
aisthesis-3151	145	40	.	.	PUNCT
aisthesis-3151	146	1	#	#	SYM
aisthesis-3151	146	2	e	e	NOUN
aisthesis-3151	146	3	ongoing	ongoing	ADJ
aisthesis-3151	146	4	checkmate	checkmate	VERB
aisthesis-3151	146	5	0214	0214	NUM
aisthesis-3151	146	6	trial	trial	NOUN
aisthesis-3151	146	7	has	have	AUX
aisthesis-3151	146	8	shown	show	VERB
aisthesis-3151	146	9	that	that	SCONJ
aisthesis-3151	146	10	combining	combine	VERB
aisthesis-3151	146	11	nivolumab	nivolumab	NOUN
aisthesis-3151	146	12	and	and	CCONJ
aisthesis-3151	146	13	ipilimumab	ipilimumab	VERB
aisthesis-3151	146	14	yields	yield	NOUN
aisthesis-3151	146	15	even	even	ADV
aisthesis-3151	146	16	better	well	ADJ
aisthesis-3151	146	17	survival	survival	NOUN
aisthesis-3151	146	18	outcomes	outcome	NOUN
aisthesis-3151	146	19	than	than	ADP
aisthesis-3151	146	20	vegf	vegf	PROPN
aisthesis-3151	146	21	-	-	PUNCT
aisthesis-3151	146	22	tkis	tkis	PROPN
aisthesis-3151	146	23	,	,	PUNCT
aisthesis-3151	146	24	indicating	indicate	VERB
aisthesis-3151	146	25	that	that	SCONJ
aisthesis-3151	146	26	immunotherapy	immunotherapy	NOUN
aisthesis-3151	146	27	agents	agent	NOUN
aisthesis-3151	146	28	may	may	AUX
aisthesis-3151	146	29	be	be	AUX
aisthesis-3151	146	30	superior	superior	ADJ
aisthesis-3151	146	31	in	in	ADP
aisthesis-3151	146	32	managing	manage	VERB
aisthesis-3151	146	33	renal	renal	ADJ
aisthesis-3151	146	34	cell	cell	NOUN
aisthesis-3151	146	35	carcinoma	carcinoma	NOUN
aisthesis-3151	146	36	.	.	PUNCT
aisthesis-3151	147	1	with	with	ADP
aisthesis-3151	147	2	the	the	DET
aisthesis-3151	147	3	accumulation	accumulation	NOUN
aisthesis-3151	147	4	of	of	ADP
aisthesis-3151	147	5	several	several	ADJ
aisthesis-3151	147	6	treatment	treatment	NOUN
aisthesis-3151	147	7	options	option	NOUN
aisthesis-3151	147	8	for	for	ADP
aisthesis-3151	147	9	renal	renal	ADJ
aisthesis-3151	147	10	cell	cell	NOUN
aisthesis-3151	147	11	carcinoma	carcinoma	NOUN
aisthesis-3151	147	12	,	,	PUNCT
aisthesis-3151	147	13	we	we	PRON
aisthesis-3151	147	14	have	have	AUX
aisthesis-3151	147	15	entered	enter	VERB
aisthesis-3151	147	16	into	into	ADP
aisthesis-3151	147	17	an	an	DET
aisthesis-3151	147	18	exciting	exciting	ADJ
aisthesis-3151	147	19	era	era	NOUN
aisthesis-3151	147	20	of	of	ADP
aisthesis-3151	147	21	developing	develop	VERB
aisthesis-3151	147	22	personalized	personalized	ADJ
aisthesis-3151	147	23	treatment	treatment	NOUN
aisthesis-3151	147	24	regimens	regimen	NOUN
aisthesis-3151	147	25	for	for	ADP
aisthesis-3151	147	26	di!erent	di!erent	NOUN
aisthesis-3151	147	27	cohorts	cohort	NOUN
aisthesis-3151	147	28	of	of	ADP
aisthesis-3151	147	29	patients	patient	NOUN
aisthesis-3151	147	30	.	.	PUNCT
aisthesis-3151	148	1	can	can	AUX
aisthesis-3151	148	2	we	we	PRON
aisthesis-3151	148	3	predict	predict	VERB
aisthesis-3151	148	4	who	who	PRON
aisthesis-3151	148	5	will	will	AUX
aisthesis-3151	148	6	respond	respond	VERB
aisthesis-3151	148	7	well	well	ADV
aisthesis-3151	148	8	to	to	ADP
aisthesis-3151	148	9	immunotherapies	immunotherapy	NOUN
aisthesis-3151	148	10	?	?	PUNCT
aisthesis-3151	149	1	does	do	AUX
aisthesis-3151	149	2	combining	combine	VERB
aisthesis-3151	149	3	immunotherapies	immunotherapy	NOUN
aisthesis-3151	149	4	with	with	ADP
aisthesis-3151	149	5	other	other	ADJ
aisthesis-3151	149	6	types	type	NOUN
aisthesis-3151	149	7	of	of	ADP
aisthesis-3151	149	8	anti	anti	ADJ
aisthesis-3151	149	9	-	-	ADJ
aisthesis-3151	149	10	cancer	cancer	ADJ
aisthesis-3151	149	11	drugs	drug	NOUN
aisthesis-3151	149	12	confer	confer	VERB
aisthesis-3151	149	13	even	even	ADV
aisthesis-3151	149	14	better	well	ADJ
aisthesis-3151	149	15	survival	survival	NOUN
aisthesis-3151	149	16	outcomes	outcome	NOUN
aisthesis-3151	149	17	?	?	PUNCT
aisthesis-3151	150	1	as	as	SCONJ
aisthesis-3151	150	2	the	the	DET
aisthesis-3151	150	3	$	$	SYM
aisthesis-3151	150	4	ndings	nding	NOUN
aisthesis-3151	150	5	from	from	ADP
aisthesis-3151	150	6	new	new	ADJ
aisthesis-3151	150	7	clinical	clinical	ADJ
aisthesis-3151	150	8	trials	trial	NOUN
aisthesis-3151	150	9	are	be	AUX
aisthesis-3151	150	10	published	publish	VERB
aisthesis-3151	150	11	,	,	PUNCT
aisthesis-3151	150	12	the	the	DET
aisthesis-3151	150	13	treatment	treatment	NOUN
aisthesis-3151	150	14	and	and	CCONJ
aisthesis-3151	150	15	management	management	NOUN
aisthesis-3151	150	16	of	of	ADP
aisthesis-3151	150	17	renal	renal	ADJ
aisthesis-3151	150	18	cell	cell	NOUN
aisthesis-3151	150	19	carcinoma	carcinoma	NOUN
aisthesis-3151	150	20	will	will	AUX
aisthesis-3151	150	21	continue	continue	VERB
aisthesis-3151	150	22	to	to	PART
aisthesis-3151	150	23	evolve	evolve	VERB
aisthesis-3151	150	24	.	.	PUNCT
aisthesis-3151	151	1	references	reference	NOUN
aisthesis-3151	151	2	american	american	PROPN
aisthesis-3151	151	3	cancer	cancer	NOUN
aisthesis-3151	151	4	society	society	NOUN
aisthesis-3151	151	5	.	.	PUNCT
aisthesis-3151	152	1	(	(	PUNCT
aisthesis-3151	152	2	2018	2018	NUM
aisthesis-3151	152	3	,	,	PUNCT
aisthesis-3151	152	4	april	april	PROPN
aisthesis-3151	152	5	27	27	NUM
aisthesis-3151	152	6	)	)	PUNCT
aisthesis-3151	152	7	.	.	PUNCT
aisthesis-3151	153	1	cancer	cancer	NOUN
aisthesis-3151	153	2	facts	fact	NOUN
aisthesis-3151	153	3	&	&	CCONJ
aisthesis-3151	153	4	"	"	PUNCT
aisthesis-3151	153	5	gures	gure	VERB
aisthesis-3151	153	6	2018	2018	NUM
aisthesis-3151	153	7	.	.	PUNCT
aisthesis-3151	154	1	https://www.cancer	https://www.cancer	NOUN
aisthesis-3151	154	2	.	.	PUNCT
aisthesis-3151	155	1	org	org	ADJ
aisthesis-3151	155	2	/	/	SYM
aisthesis-3151	155	3	content	content	NOUN
aisthesis-3151	155	4	/	/	SYM
aisthesis-3151	155	5	dam/	dam/	PROPN
aisthesis-3151	155	6	...	...	PUNCT
aisthesis-3151	155	7	/2018	/2018	PUNCT
aisthesis-3151	155	8	/	/	SYM
aisthesis-3151	155	9	cancer	cancer	NOUN
aisthesis-3151	155	10	-	-	PUNCT
aisthesis-3151	155	11	facts	fact	NOUN
aisthesis-3151	155	12	-	-	PUNCT
aisthesis-3151	155	13	and$gures-2018.pdf	and$gures-2018.pdf	NOUN
aisthesis-3151	155	14	atkins	atkins	PROPN
aisthesis-3151	155	15	,	,	PUNCT
aisthesis-3151	155	16	m.	m.	PROPN
aisthesis-3151	155	17	b.	b.	PROPN
aisthesis-3151	155	18	,	,	PUNCT
aisthesis-3151	155	19	sparano	sparano	PROPN
aisthesis-3151	155	20	,	,	PUNCT
aisthesis-3151	155	21	j.	j.	PROPN
aisthesis-3151	155	22	,	,	PUNCT
aisthesis-3151	155	23	fisher	fisher	PROPN
aisthesis-3151	155	24	,	,	PUNCT
aisthesis-3151	155	25	r.	r.	PROPN
aisthesis-3151	155	26	i.	i.	PROPN
aisthesis-3151	155	27	,	,	PUNCT
aisthesis-3151	155	28	weiss	weiss	PROPN
aisthesis-3151	155	29	,	,	PUNCT
aisthesis-3151	155	30	g.	g.	PROPN
aisthesis-3151	155	31	r.	r.	PROPN
aisthesis-3151	155	32	,	,	PUNCT
aisthesis-3151	155	33	margolin	margolin	PROPN
aisthesis-3151	155	34	,	,	PUNCT
aisthesis-3151	155	35	k.	k.	PROPN
aisthesis-3151	155	36	a.	a.	PROPN
aisthesis-3151	155	37	,	,	PUNCT
aisthesis-3151	155	38	fink	fink	PROPN
aisthesis-3151	155	39	,	,	PUNCT
aisthesis-3151	155	40	k.	k.	PROPN
aisthesis-3151	156	1	i	i	PRON
aisthesis-3151	156	2	…	…	PUNCT
aisthesis-3151	156	3	.	.	PUNCT
aisthesis-3151	157	1	gucalp	gucalp	PROPN
aisthesis-3151	157	2	r.	r.	PROPN
aisthesis-3151	157	3	(	(	PUNCT
aisthesis-3151	157	4	1993	1993	NUM
aisthesis-3151	157	5	)	)	PUNCT
aisthesis-3151	157	6	.	.	PUNCT
aisthesis-3151	158	1	randomized	randomize	VERB
aisthesis-3151	158	2	phase	phase	NOUN
aisthesis-3151	158	3	ii	ii	NOUN
aisthesis-3151	158	4	trial	trial	NOUN
aisthesis-3151	158	5	of	of	ADP
aisthesis-3151	158	6	high	high	ADJ
aisthesis-3151	158	7	-	-	PUNCT
aisthesis-3151	158	8	dose	dose	NOUN
aisthesis-3151	158	9	interleukin-2	interleukin-2	NOUN
aisthesis-3151	158	10	either	either	CCONJ
aisthesis-3151	158	11	alone	alone	ADJ
aisthesis-3151	158	12	or	or	CCONJ
aisthesis-3151	158	13	in	in	ADP
aisthesis-3151	158	14	combination	combination	NOUN
aisthesis-3151	158	15	with	with	ADP
aisthesis-3151	158	16	interferon	interferon	NOUN
aisthesis-3151	158	17	alfa-2b	alfa-2b	CCONJ
aisthesis-3151	158	18	in	in	ADP
aisthesis-3151	158	19	advanced	advanced	ADJ
aisthesis-3151	158	20	renal	renal	ADJ
aisthesis-3151	158	21	cell	cell	NOUN
aisthesis-3151	158	22	carcinoma	carcinoma	NOUN
aisthesis-3151	158	23	.	.	PUNCT
aisthesis-3151	159	1	journal	journal	NOUN
aisthesis-3151	159	2	of	of	ADP
aisthesis-3151	159	3	clinical	clinical	ADJ
aisthesis-3151	159	4	oncology	oncology	NOUN
aisthesis-3151	159	5	,	,	PUNCT
aisthesis-3151	159	6	11(4	11(4	NUM
aisthesis-3151	159	7	)	)	PUNCT
aisthesis-3151	159	8	,	,	PUNCT
aisthesis-3151	159	9	661	661	NUM
aisthesis-3151	159	10	-	-	SYM
aisthesis-3151	159	11	670	670	NUM
aisthesis-3151	159	12	.	.	PUNCT
aisthesis-3151	160	1	bianchi	bianchi	PROPN
aisthesis-3151	160	2	,	,	PUNCT
aisthesis-3151	160	3	m.	m.	NOUN
aisthesis-3151	160	4	,	,	PUNCT
aisthesis-3151	160	5	sun	sun	NOUN
aisthesis-3151	160	6	,	,	PUNCT
aisthesis-3151	160	7	m.	m.	NOUN
aisthesis-3151	160	8	,	,	PUNCT
aisthesis-3151	160	9	jeldres	jeldre	NOUN
aisthesis-3151	160	10	,	,	PUNCT
aisthesis-3151	160	11	c.	c.	PROPN
aisthesis-3151	160	12	,	,	PUNCT
aisthesis-3151	160	13	shariat	shariat	PROPN
aisthesis-3151	160	14	,	,	PUNCT
aisthesis-3151	160	15	s.	s.	PROPN
aisthesis-3151	160	16	f.	f.	PROPN
aisthesis-3151	160	17	,	,	PUNCT
aisthesis-3151	160	18	trinh	trinh	PROPN
aisthesis-3151	160	19	,	,	PUNCT
aisthesis-3151	160	20	q.	q.	PROPN
aisthesis-3151	160	21	d.	d.	PROPN
aisthesis-3151	160	22	,	,	PUNCT
aisthesis-3151	160	23	briganti	briganti	PROPN
aisthesis-3151	160	24	,	,	PUNCT
aisthesis-3151	160	25	a.	a.	NOUN
aisthesis-3151	160	26	.	.	PUNCT
aisthesis-3151	160	27	.	.	PUNCT
aisthesis-3151	160	28	.	.	PUNCT
aisthesis-3151	161	1	karakiewicz	karakiewicz	NOUN
aisthesis-3151	161	2	,	,	PUNCT
aisthesis-3151	161	3	p.	p.	NOUN
aisthesis-3151	161	4	i.	i.	PROPN
aisthesis-3151	161	5	(	(	PUNCT
aisthesis-3151	161	6	2012	2012	NUM
aisthesis-3151	161	7	)	)	PUNCT
aisthesis-3151	161	8	.	.	PUNCT
aisthesis-3151	162	1	distribution	distribution	NOUN
aisthesis-3151	162	2	of	of	ADP
aisthesis-3151	162	3	metastatic	metastatic	ADJ
aisthesis-3151	162	4	sites	site	NOUN
aisthesis-3151	162	5	in	in	ADP
aisthesis-3151	162	6	renal	renal	ADJ
aisthesis-3151	162	7	cell	cell	NOUN
aisthesis-3151	162	8	carcinoma	carcinoma	NOUN
aisthesis-3151	162	9	:	:	PUNCT
aisthesis-3151	162	10	a	a	DET
aisthesis-3151	162	11	population	population	NOUN
aisthesis-3151	162	12	-	-	PUNCT
aisthesis-3151	162	13	based	base	VERB
aisthesis-3151	162	14	analysis	analysis	NOUN
aisthesis-3151	162	15	.	.	PUNCT
aisthesis-3151	163	1	annals	annal	NOUN
aisthesis-3151	163	2	of	of	ADP
aisthesis-3151	163	3	oncology	oncology	NOUN
aisthesis-3151	163	4	,	,	PUNCT
aisthesis-3151	163	5	23(4	23(4	NOUN
aisthesis-3151	163	6	)	)	PUNCT
aisthesis-3151	163	7	,	,	PUNCT
aisthesis-3151	163	8	973	973	NUM
aisthesis-3151	163	9	-	-	SYM
aisthesis-3151	163	10	980	980	NUM
aisthesis-3151	163	11	.	.	PUNCT
aisthesis-3151	164	1	brunda	brunda	NOUN
aisthesis-3151	164	2	,	,	PUNCT
aisthesis-3151	164	3	m.	m.	NOUN
aisthesis-3151	164	4	j.	j.	PROPN
aisthesis-3151	164	5	,	,	PUNCT
aisthesis-3151	164	6	bellantoni	bellantoni	PROPN
aisthesis-3151	164	7	,	,	PUNCT
aisthesis-3151	164	8	d.	d.	PROPN
aisthesis-3151	164	9	,	,	PUNCT
aisthesis-3151	164	10	&	&	CCONJ
aisthesis-3151	164	11	sulich	sulich	PROPN
aisthesis-3151	164	12	,	,	PUNCT
aisthesis-3151	164	13	v.	v.	PROPN
aisthesis-3151	164	14	(	(	PUNCT
aisthesis-3151	164	15	1987	1987	NUM
aisthesis-3151	164	16	)	)	PUNCT
aisthesis-3151	164	17	.	.	PUNCT
aisthesis-3151	165	1	in	in	ADP
aisthesis-3151	165	2	vivo	vivo	ADJ
aisthesis-3151	165	3	anti	anti	ADJ
aisthesis-3151	165	4	tumor	tumor	NOUN
aisthesis-3151	165	5	activity	activity	NOUN
aisthesis-3151	165	6	of	of	ADP
aisthesis-3151	165	7	combinations	combination	NOUN
aisthesis-3151	165	8	of	of	ADP
aisthesis-3151	165	9	interferon	interferon	ADJ
aisthesis-3151	165	10	alpha	alpha	NOUN
aisthesis-3151	165	11	and	and	CCONJ
aisthesis-3151	165	12	interleukin-2	interleukin-2	NOUN
aisthesis-3151	165	13	in	in	ADP
aisthesis-3151	165	14	a	a	DET
aisthesis-3151	165	15	murine	murine	ADJ
aisthesis-3151	165	16	model	model	NOUN
aisthesis-3151	165	17	.	.	PUNCT
aisthesis-3151	166	1	correlation	correlation	NOUN
aisthesis-3151	166	2	of	of	ADP
aisthesis-3151	166	3	e(cacy	e(cacy	NOUN
aisthesis-3151	166	4	with	with	ADP
aisthesis-3151	166	5	the	the	DET
aisthesis-3151	166	6	induction	induction	NOUN
aisthesis-3151	166	7	of	of	ADP
aisthesis-3151	166	8	cytotoxic	cytotoxic	ADJ
aisthesis-3151	166	9	cells	cell	NOUN
aisthesis-3151	166	10	resembling	resemble	VERB
aisthesis-3151	166	11	natural	natural	ADJ
aisthesis-3151	166	12	killer	killer	NOUN
aisthesis-3151	166	13	cells	cell	NOUN
aisthesis-3151	166	14	.	.	PUNCT
aisthesis-3151	167	1	international	international	ADJ
aisthesis-3151	167	2	journal	journal	PROPN
aisthesis-3151	167	3	of	of	ADP
aisthesis-3151	167	4	cancer	cancer	NOUN
aisthesis-3151	167	5	,	,	PUNCT
aisthesis-3151	167	6	40(3	40(3	NUM
aisthesis-3151	167	7	)	)	PUNCT
aisthesis-3151	167	8	,	,	PUNCT
aisthesis-3151	167	9	365	365	NUM
aisthesis-3151	167	10	-	-	SYM
aisthesis-3151	167	11	371	371	NUM
aisthesis-3151	167	12	.	.	PUNCT
aisthesis-3151	168	1	capitanio	capitanio	NOUN
aisthesis-3151	168	2	,	,	PUNCT
aisthesis-3151	168	3	u.	u.	PROPN
aisthesis-3151	168	4	,	,	PUNCT
aisthesis-3151	168	5	bensalah	bensalah	PROPN
aisthesis-3151	168	6	,	,	PUNCT
aisthesis-3151	168	7	k.	k.	PROPN
aisthesis-3151	168	8	,	,	PUNCT
aisthesis-3151	168	9	bex	bex	PROPN
aisthesis-3151	168	10	,	,	PUNCT
aisthesis-3151	168	11	a.	a.	NOUN
aisthesis-3151	168	12	,	,	PUNCT
aisthesis-3151	168	13	boorjian	boorjian	ADJ
aisthesis-3151	168	14	,	,	PUNCT
aisthesis-3151	168	15	s.	s.	PROPN
aisthesis-3151	168	16	,	,	PUNCT
aisthesis-3151	168	17	bray	bray	PROPN
aisthesis-3151	168	18	,	,	PUNCT
aisthesis-3151	168	19	f.	f.	PROPN
aisthesis-3151	168	20	,	,	PUNCT
aisthesis-3151	168	21	coleman	coleman	PROPN
aisthesis-3151	168	22	,	,	PUNCT
aisthesis-3151	168	23	j.	j.	PROPN
aisthesis-3151	168	24	,	,	PUNCT
aisthesis-3151	168	25	.	.	PUNCT
aisthesis-3151	168	26	.	.	PUNCT
aisthesis-3151	168	27	.	.	PUNCT
aisthesis-3151	169	1	russo	russo	PROPN
aisthesis-3151	169	2	,	,	PUNCT
aisthesis-3151	169	3	p.	p.	NOUN
aisthesis-3151	169	4	(	(	PUNCT
aisthesis-3151	169	5	2019	2019	NUM
aisthesis-3151	169	6	)	)	PUNCT
aisthesis-3151	169	7	.	.	PUNCT
aisthesis-3151	170	1	epidemiology	epidemiology	NOUN
aisthesis-3151	170	2	of	of	ADP
aisthesis-3151	170	3	renal	renal	ADJ
aisthesis-3151	170	4	cell	cell	NOUN
aisthesis-3151	170	5	carcinoma	carcinoma	NOUN
aisthesis-3151	170	6	.	.	PUNCT
aisthesis-3151	171	1	european	european	ADJ
aisthesis-3151	171	2	urology	urology	NOUN
aisthesis-3151	171	3	,	,	PUNCT
aisthesis-3151	171	4	75(1	75(1	NOUN
aisthesis-3151	171	5	)	)	PUNCT
aisthesis-3151	171	6	,	,	PUNCT
aisthesis-3151	171	7	74	74	NUM
aisthesis-3151	171	8	-	-	SYM
aisthesis-3151	171	9	84	84	NUM
aisthesis-3151	171	10	.	.	PUNCT
aisthesis-3151	172	1	catino	catino	NOUN
aisthesis-3151	172	2	,	,	PUNCT
aisthesis-3151	172	3	a.	a.	PROPN
aisthesis-3151	172	4	b.	b.	PROPN
aisthesis-3151	172	5	,	,	PUNCT
aisthesis-3151	172	6	hubbard	hubbard	PROPN
aisthesis-3151	172	7	,	,	PUNCT
aisthesis-3151	172	8	r.	r.	PROPN
aisthesis-3151	172	9	a.	a.	PROPN
aisthesis-3151	172	10	,	,	PUNCT
aisthesis-3151	172	11	chirinos	chirinos	PROPN
aisthesis-3151	172	12	,	,	PUNCT
aisthesis-3151	172	13	j.	j.	PROPN
aisthesis-3151	172	14	c.	c.	PROPN
aisthesis-3151	172	15	,	,	PUNCT
aisthesis-3151	172	16	townsend	townsend	PROPN
aisthesis-3151	172	17	,	,	PUNCT
aisthesis-3151	172	18	r.	r.	PROPN
aisthesis-3151	172	19	m.	m.	PROPN
aisthesis-3151	172	20	,	,	PUNCT
aisthesis-3151	172	21	keefe	keefe	PROPN
aisthesis-3151	172	22	,	,	PUNCT
aisthesis-3151	172	23	s.	s.	PROPN
aisthesis-3151	172	24	,	,	PUNCT
aisthesis-3151	172	25	haas	haas	PROPN
aisthesis-3151	172	26	,	,	PUNCT
aisthesis-3151	172	27	n.	n.	NOUN
aisthesis-3151	172	28	,	,	PUNCT
aisthesis-3151	172	29	.	.	PUNCT
aisthesis-3151	172	30	.	.	PUNCT
aisthesis-3151	172	31	.	.	PUNCT
aisthesis-3151	173	1	ky	ky	PROPN
aisthesis-3151	173	2	,	,	PUNCT
aisthesis-3151	173	3	b.	b.	PROPN
aisthesis-3151	173	4	(	(	PUNCT
aisthesis-3151	173	5	2018	2018	NUM
aisthesis-3151	173	6	)	)	PUNCT
aisthesis-3151	173	7	.	.	PUNCT
aisthesis-3151	174	1	longitudinal	longitudinal	ADJ
aisthesis-3151	174	2	assessment	assessment	NOUN
aisthesis-3151	174	3	of	of	ADP
aisthesis-3151	174	4	vascular	vascular	ADJ
aisthesis-3151	174	5	function	function	NOUN
aisthesis-3151	174	6	with	with	ADP
aisthesis-3151	174	7	sunitinib	sunitinib	NOUN
aisthesis-3151	174	8	in	in	ADP
aisthesis-3151	174	9	patients	patient	NOUN
aisthesis-3151	174	10	with	with	ADP
aisthesis-3151	174	11	metastatic	metastatic	ADJ
aisthesis-3151	174	12	renal	renal	ADJ
aisthesis-3151	174	13	cell	cell	NOUN
aisthesis-3151	174	14	carcinoma	carcinoma	NOUN
aisthesis-3151	174	15	.	.	PUNCT
aisthesis-3151	175	1	circulation	circulation	NOUN
aisthesis-3151	175	2	:	:	PUNCT
aisthesis-3151	175	3	heart	heart	NOUN
aisthesis-3151	175	4	failure	failure	NOUN
aisthesis-3151	175	5	,	,	PUNCT
aisthesis-3151	175	6	11(3	11(3	NUM
aisthesis-3151	175	7	)	)	PUNCT
aisthesis-3151	175	8	,	,	PUNCT
aisthesis-3151	175	9	e004408	e004408	PROPN
aisthesis-3151	175	10	.	.	PUNCT
aisthesis-3151	175	11	challis	challi	NOUN
aisthesis-3151	175	12	,	,	PUNCT
aisthesis-3151	175	13	g.	g.	PROPN
aisthesis-3151	175	14	,	,	PUNCT
aisthesis-3151	175	15	&	&	CCONJ
aisthesis-3151	175	16	stam	stam	PROPN
aisthesis-3151	175	17	,	,	PUNCT
aisthesis-3151	175	18	h.	h.	PROPN
aisthesis-3151	175	19	(	(	PUNCT
aisthesis-3151	175	20	1990	1990	NUM
aisthesis-3151	175	21	)	)	PUNCT
aisthesis-3151	175	22	.	.	PUNCT
aisthesis-3151	176	1	#	#	SYM
aisthesis-3151	176	2	e	e	NOUN
aisthesis-3151	176	3	spontaneous	spontaneous	ADJ
aisthesis-3151	176	4	regression	regression	NOUN
aisthesis-3151	176	5	of	of	ADP
aisthesis-3151	176	6	cancer	cancer	NOUN
aisthesis-3151	176	7	.	.	PUNCT
aisthesis-3151	177	1	a	a	DET
aisthesis-3151	177	2	review	review	NOUN
aisthesis-3151	177	3	of	of	ADP
aisthesis-3151	177	4	cases	case	NOUN
aisthesis-3151	177	5	from	from	ADP
aisthesis-3151	177	6	1900	1900	NUM
aisthesis-3151	177	7	to	to	ADP
aisthesis-3151	177	8	1987	1987	NUM
aisthesis-3151	177	9	.	.	PUNCT
aisthesis-3151	178	1	acta	acta	PROPN
aisthesis-3151	178	2	oncologica	oncologica	PROPN
aisthesis-3151	178	3	(	(	PUNCT
aisthesis-3151	178	4	stockholm	stockholm	PROPN
aisthesis-3151	178	5	,	,	PUNCT
aisthesis-3151	178	6	sweden	sweden	PROPN
aisthesis-3151	178	7	)	)	PUNCT
aisthesis-3151	178	8	,	,	PUNCT
aisthesis-3151	178	9	29(5	29(5	NUM
aisthesis-3151	178	10	)	)	PUNCT
aisthesis-3151	178	11	,	,	PUNCT
aisthesis-3151	178	12	545	545	NUM
aisthesis-3151	178	13	-	-	SYM
aisthesis-3151	178	14	550	550	NUM
aisthesis-3151	178	15	.	.	PUNCT
aisthesis-3151	179	1	fyfe	fyfe	PROPN
aisthesis-3151	179	2	,	,	PUNCT
aisthesis-3151	179	3	g.	g.	PROPN
aisthesis-3151	179	4	,	,	PUNCT
aisthesis-3151	179	5	fisher	fisher	PROPN
aisthesis-3151	179	6	,	,	PUNCT
aisthesis-3151	179	7	r.	r.	PROPN
aisthesis-3151	179	8	i.	i.	PROPN
aisthesis-3151	179	9	,	,	PUNCT
aisthesis-3151	179	10	rosenburg	rosenburg	PROPN
aisthesis-3151	179	11	,	,	PUNCT
aisthesis-3151	179	12	s.	s.	PROPN
aisthesis-3151	179	13	a.	a.	PROPN
aisthesis-3151	179	14	,	,	PUNCT
aisthesis-3151	179	15	sznol	sznol	NOUN
aisthesis-3151	179	16	,	,	PUNCT
aisthesis-3151	179	17	m.	m.	NOUN
aisthesis-3151	179	18	,	,	PUNCT
aisthesis-3151	179	19	parkinson	parkinson	NOUN
aisthesis-3151	179	20	,	,	PUNCT
aisthesis-3151	179	21	d.	d.	PROPN
aisthesis-3151	179	22	r.	r.	PROPN
aisthesis-3151	179	23	,	,	PUNCT
aisthesis-3151	179	24	&	&	CCONJ
aisthesis-3151	179	25	louie	louie	PROPN
aisthesis-3151	179	26	,	,	PUNCT
aisthesis-3151	179	27	a.	a.	PROPN
aisthesis-3151	179	28	c.	c.	PROPN
aisthesis-3151	179	29	(	(	PUNCT
aisthesis-3151	179	30	1995	1995	NUM
aisthesis-3151	179	31	)	)	PUNCT
aisthesis-3151	179	32	.	.	PUNCT
aisthesis-3151	180	1	results	result	NOUN
aisthesis-3151	180	2	of	of	ADP
aisthesis-3151	180	3	treatment	treatment	NOUN
aisthesis-3151	180	4	of	of	ADP
aisthesis-3151	180	5	255	255	NUM
aisthesis-3151	180	6	patients	patient	NOUN
aisthesis-3151	180	7	with	with	ADP
aisthesis-3151	180	8	metastatic	metastatic	ADJ
aisthesis-3151	180	9	renal	renal	ADJ
aisthesis-3151	180	10	cell	cell	NOUN
aisthesis-3151	180	11	carcinoma	carcinoma	NOUN
aisthesis-3151	180	12	who	who	PRON
aisthesis-3151	180	13	received	receive	VERB
aisthesis-3151	180	14	high	high	ADJ
aisthesis-3151	180	15	-	-	PUNCT
aisthesis-3151	180	16	dose	dose	NOUN
aisthesis-3151	180	17	recombinant	recombinant	ADJ
aisthesis-3151	180	18	interleukin-2	interleukin-2	NUM
aisthesis-3151	180	19	therapy	therapy	NOUN
aisthesis-3151	180	20	.	.	PUNCT
aisthesis-3151	181	1	journal	journal	NOUN
aisthesis-3151	181	2	of	of	ADP
aisthesis-3151	181	3	clinical	clinical	ADJ
aisthesis-3151	181	4	oncology	oncology	NOUN
aisthesis-3151	181	5	,	,	PUNCT
aisthesis-3151	181	6	13(3	13(3	NUM
aisthesis-3151	181	7	)	)	PUNCT
aisthesis-3151	181	8	,	,	PUNCT
aisthesis-3151	181	9	688	688	NUM
aisthesis-3151	181	10	-	-	SYM
aisthesis-3151	181	11	696	696	NUM
aisthesis-3151	181	12	.	.	PUNCT
aisthesis-3151	182	1	hodi	hodi	PROPN
aisthesis-3151	182	2	,	,	PUNCT
aisthesis-3151	182	3	f.	f.	PROPN
aisthesis-3151	182	4	,	,	PUNCT
aisthesis-3151	182	5	o’day	o’day	NUM
aisthesis-3151	182	6	,	,	PUNCT
aisthesis-3151	182	7	s.	s.	PROPN
aisthesis-3151	182	8	,	,	PUNCT
aisthesis-3151	182	9	mcdermott	mcdermott	PROPN
aisthesis-3151	182	10	,	,	PUNCT
aisthesis-3151	182	11	d.	d.	PROPN
aisthesis-3151	182	12	,	,	PUNCT
aisthesis-3151	182	13	weber	weber	PROPN
aisthesis-3151	182	14	,	,	PUNCT
aisthesis-3151	182	15	r.	r.	PROPN
aisthesis-3151	182	16	,	,	PUNCT
aisthesis-3151	182	17	sosman	sosman	NOUN
aisthesis-3151	182	18	,	,	PUNCT
aisthesis-3151	182	19	j.	j.	PROPN
aisthesis-3151	182	20	,	,	PUNCT
aisthesis-3151	182	21	haanen	haanen	PROPN
aisthesis-3151	182	22	,	,	PUNCT
aisthesis-3151	182	23	j.	j.	PROPN
aisthesis-3151	182	24	,	,	PUNCT
aisthesis-3151	182	25	.	.	PUNCT
aisthesis-3151	182	26	.	.	PUNCT
aisthesis-3151	182	27	.	.	PUNCT
aisthesis-3151	183	1	lebbé	lebbé	PROPN
aisthesis-3151	183	2	,	,	PUNCT
aisthesis-3151	183	3	c.	c.	PROPN
aisthesis-3151	183	4	(	(	PUNCT
aisthesis-3151	183	5	2010	2010	NUM
aisthesis-3151	183	6	)	)	PUNCT
aisthesis-3151	183	7	.	.	PUNCT
aisthesis-3151	184	1	improved	improved	ADJ
aisthesis-3151	184	2	survival	survival	NOUN
aisthesis-3151	184	3	with	with	ADP
aisthesis-3151	184	4	ipilimumab	ipilimumab	NOUN
aisthesis-3151	184	5	in	in	ADP
aisthesis-3151	184	6	patients	patient	NOUN
aisthesis-3151	184	7	with	with	ADP
aisthesis-3151	184	8	metastatic	metastatic	ADJ
aisthesis-3151	184	9	melanoma	melanoma	NOUN
aisthesis-3151	184	10	.	.	PUNCT
aisthesis-3151	184	11	!	!	PUNCT
aisthesis-3151	185	1	e	e	PROPN
aisthesis-3151	185	2	new	new	PROPN
aisthesis-3151	185	3	england	england	PROPN
aisthesis-3151	185	4	journal	journal	PROPN
aisthesis-3151	185	5	of	of	ADP
aisthesis-3151	185	6	medicine	medicine	NOUN
aisthesis-3151	185	7	,	,	PUNCT
aisthesis-3151	185	8	363(8	363(8	NUM
aisthesis-3151	185	9	)	)	PUNCT
aisthesis-3151	185	10	,	,	PUNCT
aisthesis-3151	185	11	711	711	NUM
aisthesis-3151	185	12	-	-	SYM
aisthesis-3151	185	13	723	723	NUM
aisthesis-3151	185	14	.	.	PUNCT
aisthesis-3151	186	1	latif	latif	PROPN
aisthesis-3151	186	2	,	,	PUNCT
aisthesis-3151	186	3	f.	f.	PROPN
aisthesis-3151	186	4	,	,	PUNCT
aisthesis-3151	186	5	tory	tory	PROPN
aisthesis-3151	186	6	,	,	PUNCT
aisthesis-3151	186	7	k.	k.	PROPN
aisthesis-3151	186	8	,	,	PUNCT
aisthesis-3151	186	9	gnarra	gnarra	PROPN
aisthesis-3151	186	10	,	,	PUNCT
aisthesis-3151	186	11	j.	j.	PROPN
aisthesis-3151	186	12	,	,	PUNCT
aisthesis-3151	186	13	yao	yao	PROPN
aisthesis-3151	186	14	,	,	PUNCT
aisthesis-3151	186	15	m.	m.	NOUN
aisthesis-3151	186	16	,	,	PUNCT
aisthesis-3151	186	17	duh	duh	PROPN
aisthesis-3151	186	18	,	,	PUNCT
aisthesis-3151	186	19	f.	f.	PROPN
aisthesis-3151	186	20	m.	m.	PROPN
aisthesis-3151	186	21	,	,	PUNCT
aisthesis-3151	186	22	orcutt	orcutt	PROPN
aisthesis-3151	186	23	,	,	PUNCT
aisthesis-3151	186	24	m.	m.	NOUN
aisthesis-3151	186	25	l	l	PROPN
aisthesis-3151	186	26	..	..	PUNCT
aisthesis-3151	186	27	.	.	PUNCT
aisthesis-3151	186	28	.	.	PUNCT
aisthesis-3151	187	1	lerman	lerman	NOUN
aisthesis-3151	187	2	,	,	PUNCT
aisthesis-3151	187	3	m.	m.	NOUN
aisthesis-3151	187	4	i.	i.	PROPN
aisthesis-3151	187	5	(	(	PUNCT
aisthesis-3151	187	6	1993	1993	NUM
aisthesis-3151	187	7	)	)	PUNCT
aisthesis-3151	187	8	.	.	PUNCT
aisthesis-3151	188	1	identi$cation	identi$cation	NOUN
aisthesis-3151	188	2	of	of	ADP
aisthesis-3151	188	3	the	the	DET
aisthesis-3151	188	4	von	von	PROPN
aisthesis-3151	188	5	hippel	hippel	PROPN
aisthesis-3151	188	6	-	-	PUNCT
aisthesis-3151	188	7	lindau	lindau	NOUN
aisthesis-3151	188	8	disease	disease	NOUN
aisthesis-3151	188	9	tumor	tumor	NOUN
aisthesis-3151	188	10	suppressor	suppressor	NOUN
aisthesis-3151	188	11	gene	gene	NOUN
aisthesis-3151	188	12	.	.	PUNCT
aisthesis-3151	189	1	science	science	NOUN
aisthesis-3151	189	2	,	,	PUNCT
aisthesis-3151	189	3	260(5112	260(5112	NUM
aisthesis-3151	189	4	)	)	PUNCT
aisthesis-3151	189	5	,	,	PUNCT
aisthesis-3151	189	6	1317	1317	NUM
aisthesis-3151	189	7	-	-	SYM
aisthesis-3151	189	8	1320	1320	NUM
aisthesis-3151	189	9	.	.	PUNCT
aisthesis-3151	190	1	mcdermott	mcdermott	PROPN
aisthesis-3151	190	2	,	,	PUNCT
aisthesis-3151	190	3	d.	d.	PROPN
aisthesis-3151	190	4	,	,	PUNCT
aisthesis-3151	190	5	drake	drake	PROPN
aisthesis-3151	190	6	,	,	PUNCT
aisthesis-3151	190	7	c.	c.	PROPN
aisthesis-3151	190	8	,	,	PUNCT
aisthesis-3151	190	9	sznol	sznol	NOUN
aisthesis-3151	190	10	,	,	PUNCT
aisthesis-3151	190	11	m.	m.	NOUN
aisthesis-3151	190	12	,	,	PUNCT
aisthesis-3151	190	13	choueiri	choueiri	NOUN
aisthesis-3151	190	14	,	,	PUNCT
aisthesis-3151	190	15	t.	t.	PROPN
aisthesis-3151	190	16	,	,	PUNCT
aisthesis-3151	190	17	powderly	powderly	ADV
aisthesis-3151	190	18	,	,	PUNCT
aisthesis-3151	190	19	j.	j.	PROPN
aisthesis-3151	190	20	,	,	PUNCT
aisthesis-3151	190	21	smith	smith	PROPN
aisthesis-3151	190	22	,	,	PUNCT
aisthesis-3151	190	23	d.	d.	PROPN
aisthesis-3151	190	24	,	,	PUNCT
aisthesis-3151	190	25	.	.	PUNCT
aisthesis-3151	190	26	.	.	PUNCT
aisthesis-3151	190	27	.	.	PUNCT
aisthesis-3151	191	1	atkins	atkins	PROPN
aisthesis-3151	191	2	,	,	PUNCT
aisthesis-3151	191	3	m.	m.	NOUN
aisthesis-3151	191	4	(	(	PUNCT
aisthesis-3151	191	5	2015	2015	NUM
aisthesis-3151	191	6	)	)	PUNCT
aisthesis-3151	191	7	.	.	PUNCT
aisthesis-3151	192	1	survival	survival	NOUN
aisthesis-3151	192	2	,	,	PUNCT
aisthesis-3151	192	3	durable	durable	ADJ
aisthesis-3151	192	4	response	response	NOUN
aisthesis-3151	192	5	,	,	PUNCT
aisthesis-3151	192	6	and	and	CCONJ
aisthesis-3151	192	7	long	long	ADJ
aisthesis-3151	192	8	-	-	PUNCT
aisthesis-3151	192	9	term	term	NOUN
aisthesis-3151	192	10	safety	safety	NOUN
aisthesis-3151	192	11	in	in	ADP
aisthesis-3151	192	12	patients	patient	NOUN
aisthesis-3151	192	13	with	with	ADP
aisthesis-3151	192	14	previously	previously	ADV
aisthesis-3151	192	15	treated	treat	VERB
aisthesis-3151	192	16	advanced	advanced	ADJ
aisthesis-3151	192	17	renal	renal	ADJ
aisthesis-3151	192	18	cell	cell	NOUN
aisthesis-3151	192	19	carcinoma	carcinoma	NOUN
aisthesis-3151	192	20	receiving	receive	VERB
aisthesis-3151	192	21	nivolumab	nivolumab	NOUN
aisthesis-3151	192	22	.	.	PUNCT
aisthesis-3151	193	1	journal	journal	NOUN
aisthesis-3151	193	2	of	of	ADP
aisthesis-3151	193	3	clinical	clinical	ADJ
aisthesis-3151	193	4	oncology	oncology	NOUN
aisthesis-3151	193	5	,	,	PUNCT
aisthesis-3151	193	6	33(18	33(18	NUM
aisthesis-3151	193	7	)	)	PUNCT
aisthesis-3151	193	8	,	,	PUNCT
aisthesis-3151	193	9	2013	2013	NUM
aisthesis-3151	193	10	-	-	SYM
aisthesis-3151	193	11	20	20	NUM
aisthesis-3151	193	12	.	.	NOUN
aisthesis-3151	193	13	7	7	NUM
aisthesis-3151	193	14	!	!	PUNCT
aisthesis-3151	194	1	e	e	X
aisthesis-3151	194	2	past	past	NOUN
aisthesis-3151	194	3	,	,	PUNCT
aisthesis-3151	194	4	present	present	ADJ
aisthesis-3151	194	5	,	,	PUNCT
aisthesis-3151	194	6	and	and	CCONJ
aisthesis-3151	194	7	future	future	NOUN
aisthesis-3151	194	8	of	of	ADP
aisthesis-3151	194	9	renal	renal	ADJ
aisthesis-3151	194	10	cell	cell	NOUN
aisthesis-3151	194	11	carcinoma	carcinoma	NOUN
aisthesis-3151	194	12	treatment	treatment	NOUN
aisthesis-3151	194	13	aisthesis	aisthesis	NOUN
aisthesis-3151	194	14	volume	volume	NOUN
aisthesis-3151	194	15	11	11	NUM
aisthesis-3151	194	16	,	,	PUNCT
aisthesis-3151	194	17	2020	2020	NUM
aisthesis-3151	194	18	melero	melero	NOUN
aisthesis-3151	194	19	,	,	PUNCT
aisthesis-3151	194	20	i.	i.	PROPN
aisthesis-3151	194	21	,	,	PUNCT
aisthesis-3151	194	22	berman	berman	PROPN
aisthesis-3151	194	23	,	,	PUNCT
aisthesis-3151	194	24	d.	d.	PROPN
aisthesis-3151	194	25	,	,	PUNCT
aisthesis-3151	194	26	aznar	aznar	PROPN
aisthesis-3151	194	27	,	,	PUNCT
aisthesis-3151	194	28	m.	m.	NOUN
aisthesis-3151	194	29	,	,	PUNCT
aisthesis-3151	194	30	korman	korman	PROPN
aisthesis-3151	194	31	,	,	PUNCT
aisthesis-3151	194	32	a.	a.	PROPN
aisthesis-3151	194	33	,	,	PUNCT
aisthesis-3151	194	34	gracia	gracia	PROPN
aisthesis-3151	194	35	,	,	PUNCT
aisthesis-3151	194	36	j.	j.	PROPN
aisthesis-3151	194	37	,	,	PUNCT
aisthesis-3151	194	38	&	&	CCONJ
aisthesis-3151	194	39	haanen	haanen	PROPN
aisthesis-3151	194	40	,	,	PUNCT
aisthesis-3151	194	41	j.	j.	PROPN
aisthesis-3151	194	42	(	(	PUNCT
aisthesis-3151	194	43	2015	2015	NUM
aisthesis-3151	194	44	)	)	PUNCT
aisthesis-3151	194	45	.	.	PUNCT
aisthesis-3151	195	1	evolving	evolve	VERB
aisthesis-3151	195	2	synergistic	synergistic	ADJ
aisthesis-3151	195	3	combinations	combination	NOUN
aisthesis-3151	195	4	of	of	ADP
aisthesis-3151	195	5	targeted	target	VERB
aisthesis-3151	195	6	immunotherapies	immunotherapy	NOUN
aisthesis-3151	195	7	to	to	PART
aisthesis-3151	195	8	combat	combat	NOUN
aisthesis-3151	195	9	cancer	cancer	NOUN
aisthesis-3151	195	10	.	.	PUNCT
aisthesis-3151	196	1	nature	nature	NOUN
aisthesis-3151	196	2	reviews	review	VERB
aisthesis-3151	196	3	cancer	cancer	NOUN
aisthesis-3151	196	4	,	,	PUNCT
aisthesis-3151	196	5	15(8	15(8	NOUN
aisthesis-3151	196	6	)	)	PUNCT
aisthesis-3151	196	7	,	,	PUNCT
aisthesis-3151	196	8	457	457	NUM
aisthesis-3151	196	9	-	-	SYM
aisthesis-3151	196	10	472	472	NUM
aisthesis-3151	196	11	.	.	PUNCT
aisthesis-3151	197	1	mendel	mendel	PROPN
aisthesis-3151	197	2	,	,	PUNCT
aisthesis-3151	197	3	d.	d.	PROPN
aisthesis-3151	197	4	,	,	PUNCT
aisthesis-3151	197	5	laird	laird	PROPN
aisthesis-3151	197	6	,	,	PUNCT
aisthesis-3151	197	7	a.	a.	PROPN
aisthesis-3151	197	8	,	,	PUNCT
aisthesis-3151	197	9	xin	xin	PROPN
aisthesis-3151	197	10	,	,	PUNCT
aisthesis-3151	197	11	x.	x.	PROPN
aisthesis-3151	197	12	,	,	PUNCT
aisthesis-3151	197	13	louie	louie	PROPN
aisthesis-3151	197	14	,	,	PUNCT
aisthesis-3151	197	15	s.	s.	PROPN
aisthesis-3151	197	16	,	,	PUNCT
aisthesis-3151	197	17	christensen	christensen	PROPN
aisthesis-3151	197	18	,	,	PUNCT
aisthesis-3151	197	19	j.	j.	PROPN
aisthesis-3151	197	20	,	,	PUNCT
aisthesis-3151	197	21	li	li	PROPN
aisthesis-3151	197	22	,	,	PUNCT
aisthesis-3151	197	23	g.	g.	PROPN
aisthesis-3151	197	24	,	,	PUNCT
aisthesis-3151	197	25	.	.	PUNCT
aisthesis-3151	197	26	.	.	PUNCT
aisthesis-3151	197	27	.	.	PUNCT
aisthesis-3151	198	1	cherrington	cherrington	PROPN
aisthesis-3151	198	2	,	,	PUNCT
aisthesis-3151	198	3	j.	j.	PROPN
aisthesis-3151	198	4	(	(	PUNCT
aisthesis-3151	198	5	2003	2003	NUM
aisthesis-3151	198	6	)	)	PUNCT
aisthesis-3151	198	7	.	.	PUNCT
aisthesis-3151	199	1	in	in	ADP
aisthesis-3151	199	2	vivo	vivo	ADJ
aisthesis-3151	199	3	antitumor	antitumor	NOUN
aisthesis-3151	199	4	activity	activity	NOUN
aisthesis-3151	199	5	of	of	ADP
aisthesis-3151	199	6	su11248	su11248	PROPN
aisthesis-3151	199	7	,	,	PUNCT
aisthesis-3151	199	8	a	a	DET
aisthesis-3151	199	9	novel	novel	ADJ
aisthesis-3151	199	10	tyrosine	tyrosine	NOUN
aisthesis-3151	199	11	kinase	kinase	NOUN
aisthesis-3151	199	12	inhibitor	inhibitor	NOUN
aisthesis-3151	199	13	targeting	target	VERB
aisthesis-3151	199	14	vascular	vascular	ADJ
aisthesis-3151	199	15	endothelial	endothelial	ADJ
aisthesis-3151	199	16	growth	growth	NOUN
aisthesis-3151	199	17	factor	factor	NOUN
aisthesis-3151	199	18	and	and	CCONJ
aisthesis-3151	199	19	platelet	platelet	ADJ
aisthesis-3151	199	20	-	-	PUNCT
aisthesis-3151	199	21	derived	derive	VERB
aisthesis-3151	199	22	growth	growth	NOUN
aisthesis-3151	199	23	factor	factor	NOUN
aisthesis-3151	199	24	receptors	receptor	NOUN
aisthesis-3151	199	25	:	:	PUNCT
aisthesis-3151	199	26	determination	determination	NOUN
aisthesis-3151	199	27	of	of	ADP
aisthesis-3151	199	28	a	a	DET
aisthesis-3151	199	29	pharmacokinetic/	pharmacokinetic/	NUM
aisthesis-3151	199	30	pharmacodynamic	pharmacodynamic	ADJ
aisthesis-3151	199	31	relationship	relationship	NOUN
aisthesis-3151	199	32	.	.	PUNCT
aisthesis-3151	200	1	clinical	clinical	ADJ
aisthesis-3151	200	2	cancer	cancer	NOUN
aisthesis-3151	200	3	research	research	NOUN
aisthesis-3151	200	4	:	:	PUNCT
aisthesis-3151	200	5	an	an	DET
aisthesis-3151	200	6	o#cial	o#cial	ADJ
aisthesis-3151	200	7	journal	journal	NOUN
aisthesis-3151	200	8	of	of	ADP
aisthesis-3151	200	9	the	the	DET
aisthesis-3151	200	10	american	american	PROPN
aisthesis-3151	200	11	association	association	PROPN
aisthesis-3151	200	12	for	for	ADP
aisthesis-3151	200	13	cancer	cancer	NOUN
aisthesis-3151	200	14	research	research	NOUN
aisthesis-3151	200	15	,	,	PUNCT
aisthesis-3151	200	16	9(1	9(1	NUM
aisthesis-3151	200	17	)	)	PUNCT
aisthesis-3151	200	18	,	,	PUNCT
aisthesis-3151	200	19	327	327	NUM
aisthesis-3151	200	20	-	-	SYM
aisthesis-3151	200	21	337	337	NUM
aisthesis-3151	200	22	.	.	PUNCT
aisthesis-3151	201	1	morabito	morabito	PROPN
aisthesis-3151	201	2	,	,	PUNCT
aisthesis-3151	201	3	a.	a.	PROPN
aisthesis-3151	201	4	,	,	PUNCT
aisthesis-3151	201	5	de	de	PROPN
aisthesis-3151	201	6	maio	maio	PROPN
aisthesis-3151	201	7	,	,	PUNCT
aisthesis-3151	201	8	e.	e.	PROPN
aisthesis-3151	201	9	,	,	PUNCT
aisthesis-3151	201	10	di	di	PROPN
aisthesis-3151	201	11	maio	maio	PROPN
aisthesis-3151	201	12	,	,	PUNCT
aisthesis-3151	201	13	m.	m.	NOUN
aisthesis-3151	201	14	,	,	PUNCT
aisthesis-3151	201	15	normanno	normanno	VERB
aisthesis-3151	201	16	,	,	PUNCT
aisthesis-3151	201	17	n.	n.	NOUN
aisthesis-3151	201	18	,	,	PUNCT
aisthesis-3151	201	19	&	&	CCONJ
aisthesis-3151	201	20	perrone	perrone	PROPN
aisthesis-3151	201	21	,	,	PUNCT
aisthesis-3151	201	22	f.	f.	PROPN
aisthesis-3151	201	23	(	(	PUNCT
aisthesis-3151	201	24	2006	2006	NUM
aisthesis-3151	201	25	)	)	PUNCT
aisthesis-3151	201	26	.	.	PUNCT
aisthesis-3151	202	1	tyrosine	tyrosine	PROPN
aisthesis-3151	202	2	kinase	kinase	VERB
aisthesis-3151	202	3	inhibitors	inhibitor	NOUN
aisthesis-3151	202	4	of	of	ADP
aisthesis-3151	202	5	vascular	vascular	ADJ
aisthesis-3151	202	6	endothelial	endothelial	ADJ
aisthesis-3151	202	7	growth	growth	NOUN
aisthesis-3151	202	8	factor	factor	NOUN
aisthesis-3151	202	9	receptors	receptor	NOUN
aisthesis-3151	202	10	in	in	ADP
aisthesis-3151	202	11	clinical	clinical	ADJ
aisthesis-3151	202	12	trials	trial	NOUN
aisthesis-3151	202	13	:	:	PUNCT
aisthesis-3151	202	14	current	current	ADJ
aisthesis-3151	202	15	status	status	NOUN
aisthesis-3151	202	16	and	and	CCONJ
aisthesis-3151	202	17	future	future	ADJ
aisthesis-3151	202	18	directions	direction	NOUN
aisthesis-3151	202	19	.	.	PUNCT
aisthesis-3151	203	1	oncologist	oncologist	NOUN
aisthesis-3151	203	2	,	,	PUNCT
aisthesis-3151	203	3	11(7	11(7	NUM
aisthesis-3151	203	4	)	)	PUNCT
aisthesis-3151	203	5	,	,	PUNCT
aisthesis-3151	203	6	753	753	NUM
aisthesis-3151	203	7	-	-	SYM
aisthesis-3151	203	8	764	764	NUM
aisthesis-3151	203	9	.	.	PUNCT
aisthesis-3151	204	1	motzer	motzer	NOUN
aisthesis-3151	204	2	,	,	PUNCT
aisthesis-3151	204	3	r.	r.	PROPN
aisthesis-3151	204	4	,	,	PUNCT
aisthesis-3151	204	5	hutson	hutson	PROPN
aisthesis-3151	204	6	,	,	PUNCT
aisthesis-3151	204	7	t.	t.	NOUN
aisthesis-3151	204	8	,	,	PUNCT
aisthesis-3151	204	9	tomczak	tomczak	NOUN
aisthesis-3151	204	10	,	,	PUNCT
aisthesis-3151	204	11	p.	p.	NOUN
aisthesis-3151	204	12	,	,	PUNCT
aisthesis-3151	204	13	michaelson	michaelson	PROPN
aisthesis-3151	204	14	,	,	PUNCT
aisthesis-3151	204	15	m.	m.	NOUN
aisthesis-3151	204	16	,	,	PUNCT
aisthesis-3151	204	17	bukowski	bukowski	PROPN
aisthesis-3151	204	18	,	,	PUNCT
aisthesis-3151	204	19	r.	r.	PROPN
aisthesis-3151	204	20	,	,	PUNCT
aisthesis-3151	204	21	rixe	rixe	NOUN
aisthesis-3151	204	22	,	,	PUNCT
aisthesis-3151	204	23	o.	o.	PROPN
aisthesis-3151	204	24	,	,	PUNCT
aisthesis-3151	204	25	.	.	PUNCT
aisthesis-3151	204	26	.	.	PUNCT
aisthesis-3151	205	1	.	.	PUNCT
aisthesis-3151	206	1	figlin	figlin	PROPN
aisthesis-3151	206	2	,	,	PUNCT
aisthesis-3151	206	3	r.	r.	PROPN
aisthesis-3151	206	4	(	(	PUNCT
aisthesis-3151	206	5	2007	2007	NUM
aisthesis-3151	206	6	)	)	PUNCT
aisthesis-3151	206	7	.	.	PUNCT
aisthesis-3151	207	1	sunitinib	sunitinib	NOUN
aisthesis-3151	207	2	versus	versus	ADP
aisthesis-3151	207	3	interferon	interferon	ADJ
aisthesis-3151	207	4	alfa	alfa	NOUN
aisthesis-3151	207	5	in	in	ADP
aisthesis-3151	207	6	metastatic	metastatic	ADJ
aisthesis-3151	207	7	renal	renal	ADJ
aisthesis-3151	207	8	-	-	PUNCT
aisthesis-3151	207	9	cell	cell	NOUN
aisthesis-3151	207	10	carcinoma	carcinoma	NOUN
aisthesis-3151	207	11	.	.	PUNCT
aisthesis-3151	207	12	!	!	PUNCT
aisthesis-3151	208	1	e	e	PROPN
aisthesis-3151	208	2	new	new	PROPN
aisthesis-3151	208	3	england	england	PROPN
aisthesis-3151	208	4	journal	journal	PROPN
aisthesis-3151	208	5	of	of	ADP
aisthesis-3151	208	6	medicine	medicine	NOUN
aisthesis-3151	208	7	,	,	PUNCT
aisthesis-3151	208	8	356(2	356(2	NUM
aisthesis-3151	208	9	)	)	PUNCT
aisthesis-3151	208	10	,	,	PUNCT
aisthesis-3151	208	11	115	115	NUM
aisthesis-3151	208	12	-	-	SYM
aisthesis-3151	208	13	124	124	NUM
aisthesis-3151	208	14	.	.	PUNCT
aisthesis-3151	209	1	motzer	motzer	NOUN
aisthesis-3151	209	2	,	,	PUNCT
aisthesis-3151	209	3	r.	r.	PROPN
aisthesis-3151	209	4	,	,	PUNCT
aisthesis-3151	209	5	tannir	tannir	NOUN
aisthesis-3151	209	6	,	,	PUNCT
aisthesis-3151	209	7	n.	n.	NOUN
aisthesis-3151	209	8	,	,	PUNCT
aisthesis-3151	209	9	mcdermott	mcdermott	PROPN
aisthesis-3151	209	10	,	,	PUNCT
aisthesis-3151	209	11	d.	d.	PROPN
aisthesis-3151	209	12	,	,	PUNCT
aisthesis-3151	209	13	arén	arén	VERB
aisthesis-3151	209	14	frontera	frontera	PROPN
aisthesis-3151	209	15	,	,	PUNCT
aisthesis-3151	209	16	o.	o.	PROPN
aisthesis-3151	209	17	,	,	PUNCT
aisthesis-3151	209	18	melichar	melichar	PROPN
aisthesis-3151	209	19	,	,	PUNCT
aisthesis-3151	209	20	b.	b.	PROPN
aisthesis-3151	209	21	,	,	PUNCT
aisthesis-3151	209	22	choueiri	choueiri	NOUN
aisthesis-3151	209	23	,	,	PUNCT
aisthesis-3151	209	24	t.	t.	PROPN
aisthesis-3151	209	25	,	,	PUNCT
aisthesis-3151	209	26	.	.	PUNCT
aisthesis-3151	209	27	.	.	PUNCT
aisthesis-3151	209	28	.	.	PUNCT
aisthesis-3151	210	1	hawkins	hawkins	PROPN
aisthesis-3151	210	2	,	,	PUNCT
aisthesis-3151	210	3	r.	r.	PROPN
aisthesis-3151	210	4	(	(	PUNCT
aisthesis-3151	210	5	2018	2018	NUM
aisthesis-3151	210	6	)	)	PUNCT
aisthesis-3151	210	7	.	.	PUNCT
aisthesis-3151	211	1	nivolumab	nivolumab	NOUN
aisthesis-3151	211	2	plus	plus	CCONJ
aisthesis-3151	211	3	ipilimumab	ipilimumab	X
aisthesis-3151	211	4	versus	versus	ADP
aisthesis-3151	211	5	sunitinib	sunitinib	NOUN
aisthesis-3151	211	6	in	in	ADP
aisthesis-3151	211	7	advanced	advanced	ADJ
aisthesis-3151	211	8	renal	renal	ADJ
aisthesis-3151	211	9	-	-	PUNCT
aisthesis-3151	211	10	cell	cell	NOUN
aisthesis-3151	211	11	carcinoma	carcinoma	NOUN
aisthesis-3151	211	12	.	.	PUNCT
aisthesis-3151	211	13	!	!	PUNCT
aisthesis-3151	212	1	e	e	PROPN
aisthesis-3151	212	2	new	new	PROPN
aisthesis-3151	212	3	england	england	PROPN
aisthesis-3151	212	4	journal	journal	PROPN
aisthesis-3151	212	5	of	of	ADP
aisthesis-3151	212	6	medicine	medicine	NOUN
aisthesis-3151	212	7	,	,	PUNCT
aisthesis-3151	212	8	378(14	378(14	NUM
aisthesis-3151	212	9	)	)	PUNCT
aisthesis-3151	212	10	,	,	PUNCT
aisthesis-3151	212	11	12771290	12771290	NUM
aisthesis-3151	212	12	.	.	PUNCT
aisthesis-3151	213	1	national	national	PROPN
aisthesis-3151	213	2	cancer	cancer	PROPN
aisthesis-3151	213	3	institute	institute	PROPN
aisthesis-3151	213	4	.	.	PUNCT
aisthesis-3151	214	1	(	(	PUNCT
aisthesis-3151	214	2	2018	2018	NUM
aisthesis-3151	214	3	,	,	PUNCT
aisthesis-3151	214	4	january	january	PROPN
aisthesis-3151	214	5	23	23	NUM
aisthesis-3151	214	6	)	)	PUNCT
aisthesis-3151	214	7	.	.	PUNCT
aisthesis-3151	215	1	axitinib	axitinib	NOUN
aisthesis-3151	215	2	and	and	CCONJ
aisthesis-3151	215	3	nivolumab	nivolumab	NOUN
aisthesis-3151	215	4	in	in	ADP
aisthesis-3151	215	5	treating	treat	VERB
aisthesis-3151	215	6	participants	participant	NOUN
aisthesis-3151	215	7	with	with	ADP
aisthesis-3151	215	8	unresectable	unresectable	ADJ
aisthesis-3151	215	9	or	or	CCONJ
aisthesis-3151	215	10	metastatic	metastatic	ADJ
aisthesis-3151	215	11	tfe	tfe	NOUN
aisthesis-3151	215	12	/	/	SYM
aisthesis-3151	215	13	translocation	translocation	NOUN
aisthesis-3151	215	14	renal	renal	ADJ
aisthesis-3151	215	15	cell	cell	NOUN
aisthesis-3151	215	16	carcinoma	carcinoma	NOUN
aisthesis-3151	215	17	(	(	PUNCT
aisthesis-3151	215	18	clinicaltrials.gov	clinicaltrials.gov	PROPN
aisthesis-3151	215	19	identi$er	identi$er	PROPN
aisthesis-3151	215	20	nct03595124	nct03595124	NOUN
aisthesis-3151	215	21	)	)	PUNCT
aisthesis-3151	215	22	.	.	PUNCT
aisthesis-3151	216	1	https://clinicaltrials.gov/ct2/	https://clinicaltrials.gov/ct2/	VERB
aisthesis-3151	216	2	show	show	NOUN
aisthesis-3151	216	3	/	/	SYM
aisthesis-3151	216	4	nct03595124	nct03595124	NOUN
aisthesis-3151	216	5	.	.	PUNCT
aisthesis-3151	217	1	pavlovich	pavlovich	PROPN
aisthesis-3151	217	2	,	,	PUNCT
aisthesis-3151	217	3	c.	c.	PROPN
aisthesis-3151	217	4	p.	p.	PROPN
aisthesis-3151	217	5	,	,	PUNCT
aisthesis-3151	217	6	schmidt	schmidt	PROPN
aisthesis-3151	217	7	,	,	PUNCT
aisthesis-3151	217	8	l.	l.	PROPN
aisthesis-3151	217	9	s.	s.	PROPN
aisthesis-3151	217	10	,	,	PUNCT
aisthesis-3151	217	11	&	&	CCONJ
aisthesis-3151	217	12	phillips	phillips	PROPN
aisthesis-3151	217	13	,	,	PUNCT
aisthesis-3151	217	14	j.	j.	PROPN
aisthesis-3151	217	15	l.	l.	PROPN
aisthesis-3151	217	16	(	(	PUNCT
aisthesis-3151	217	17	2003	2003	NUM
aisthesis-3151	217	18	)	)	PUNCT
aisthesis-3151	217	19	.	.	PUNCT
aisthesis-3151	218	1	#	#	SYM
aisthesis-3151	218	2	e	e	NOUN
aisthesis-3151	218	3	genetic	genetic	ADJ
aisthesis-3151	218	4	basis	basis	NOUN
aisthesis-3151	218	5	of	of	ADP
aisthesis-3151	218	6	renal	renal	ADJ
aisthesis-3151	218	7	cell	cell	NOUN
aisthesis-3151	218	8	carcinoma	carcinoma	NOUN
aisthesis-3151	218	9	.	.	PUNCT
aisthesis-3151	219	1	urologic	urologic	ADJ
aisthesis-3151	219	2	clinics	clinic	NOUN
aisthesis-3151	219	3	of	of	ADP
aisthesis-3151	219	4	north	north	PROPN
aisthesis-3151	219	5	america	america	PROPN
aisthesis-3151	219	6	,	,	PUNCT
aisthesis-3151	219	7	30(3	30(3	NUM
aisthesis-3151	219	8	)	)	PUNCT
aisthesis-3151	219	9	,	,	PUNCT
aisthesis-3151	219	10	437	437	NUM
aisthesis-3151	219	11	-	-	SYM
aisthesis-3151	219	12	454	454	NUM
aisthesis-3151	219	13	,	,	PUNCT
aisthesis-3151	219	14	vii	vii	PROPN
aisthesis-3151	219	15	.	.	PROPN
aisthesis-3151	219	16	schmidinger	schmidinger	PROPN
aisthesis-3151	219	17	,	,	PUNCT
aisthesis-3151	219	18	m.	m.	NOUN
aisthesis-3151	219	19	,	,	PUNCT
aisthesis-3151	219	20	zielinski	zielinski	PROPN
aisthesis-3151	219	21	,	,	PUNCT
aisthesis-3151	219	22	c.	c.	PROPN
aisthesis-3151	219	23	c.	c.	PROPN
aisthesis-3151	219	24	,	,	PUNCT
aisthesis-3151	219	25	vogl	vogl	PROPN
aisthesis-3151	219	26	,	,	PUNCT
aisthesis-3151	219	27	u.	u.	PROPN
aisthesis-3151	219	28	m.	m.	PROPN
aisthesis-3151	219	29	,	,	PUNCT
aisthesis-3151	219	30	bojic	bojic	NOUN
aisthesis-3151	219	31	,	,	PUNCT
aisthesis-3151	219	32	a.	a.	NOUN
aisthesis-3151	219	33	,	,	PUNCT
aisthesis-3151	219	34	bojic	bojic	NOUN
aisthesis-3151	219	35	,	,	PUNCT
aisthesis-3151	219	36	m.	m.	NOUN
aisthesis-3151	219	37	,	,	PUNCT
aisthesis-3151	219	38	schukro	schukro	PROPN
aisthesis-3151	219	39	,	,	PUNCT
aisthesis-3151	219	40	c.	c.	PROPN
aisthesis-3151	219	41	,	,	PUNCT
aisthesis-3151	219	42	.	.	PUNCT
aisthesis-3151	219	43	.	.	PUNCT
aisthesis-3151	220	1	.	.	PUNCT
aisthesis-3151	221	1	schmidinger	schmidinger	PROPN
aisthesis-3151	221	2	,	,	PUNCT
aisthesis-3151	221	3	h.	h.	PROPN
aisthesis-3151	221	4	(	(	PUNCT
aisthesis-3151	221	5	2008	2008	NUM
aisthesis-3151	221	6	)	)	PUNCT
aisthesis-3151	221	7	.	.	PUNCT
aisthesis-3151	222	1	cardiac	cardiac	ADJ
aisthesis-3151	222	2	toxicity	toxicity	NOUN
aisthesis-3151	222	3	of	of	ADP
aisthesis-3151	222	4	sunitinib	sunitinib	NOUN
aisthesis-3151	222	5	and	and	CCONJ
aisthesis-3151	222	6	sorafenib	sorafenib	NOUN
aisthesis-3151	222	7	in	in	ADP
aisthesis-3151	222	8	patients	patient	NOUN
aisthesis-3151	222	9	with	with	ADP
aisthesis-3151	222	10	metastatic	metastatic	ADJ
aisthesis-3151	222	11	renal	renal	ADJ
aisthesis-3151	222	12	cell	cell	NOUN
aisthesis-3151	222	13	carcinoma	carcinoma	NOUN
aisthesis-3151	222	14	.	.	PUNCT
aisthesis-3151	223	1	journal	journal	NOUN
aisthesis-3151	223	2	of	of	ADP
aisthesis-3151	223	3	clinical	clinical	ADJ
aisthesis-3151	223	4	oncology	oncology	NOUN
aisthesis-3151	223	5	,	,	PUNCT
aisthesis-3151	223	6	26(32	26(32	NUM
aisthesis-3151	223	7	)	)	PUNCT
aisthesis-3151	223	8	,	,	PUNCT
aisthesis-3151	223	9	5204	5204	NUM
aisthesis-3151	223	10	-	-	SYM
aisthesis-3151	223	11	5212	5212	NUM
aisthesis-3151	223	12	.	.	PUNCT
aisthesis-3151	224	1	takahashi	takahashi	PROPN
aisthesis-3151	224	2	,	,	PUNCT
aisthesis-3151	224	3	y.	y.	PROPN
aisthesis-3151	224	4	,	,	PUNCT
aisthesis-3151	224	5	mena	mena	PROPN
aisthesis-3151	224	6	,	,	PUNCT
aisthesis-3151	224	7	o.	o.	PROPN
aisthesis-3151	224	8	,	,	PUNCT
aisthesis-3151	224	9	srinivasan	srinivasan	NOUN
aisthesis-3151	224	10	,	,	PUNCT
aisthesis-3151	224	11	r.	r.	PROPN
aisthesis-3151	224	12	,	,	PUNCT
aisthesis-3151	224	13	igarashi	igarashi	NOUN
aisthesis-3151	224	14	,	,	PUNCT
aisthesis-3151	224	15	t.	t.	PROPN
aisthesis-3151	224	16	,	,	PUNCT
aisthesis-3151	224	17	lundqvist	lundqvist	PROPN
aisthesis-3151	224	18	,	,	PUNCT
aisthesis-3151	224	19	a.	a.	PROPN
aisthesis-3151	224	20	,	,	PUNCT
aisthesis-3151	224	21	su!redini	su!redini	NOUN
aisthesis-3151	224	22	,	,	PUNCT
aisthesis-3151	224	23	d	d	NOUN
aisthesis-3151	224	24	…	…	PUNCT
aisthesis-3151	224	25	.	.	PUNCT
aisthesis-3151	225	1	childs	childs	PROPN
aisthesis-3151	225	2	,	,	PUNCT
aisthesis-3151	225	3	r.	r.	PROPN
aisthesis-3151	225	4	(	(	PUNCT
aisthesis-3151	225	5	2004	2004	NUM
aisthesis-3151	225	6	)	)	PUNCT
aisthesis-3151	225	7	.	.	PUNCT
aisthesis-3151	226	1	cd8	cd8	PROPN
aisthesis-3151	226	2	+	+	PROPN
aisthesis-3151	226	3	t	t	PROPN
aisthesis-3151	226	4	-	-	PUNCT
aisthesis-3151	226	5	cells	cell	NOUN
aisthesis-3151	226	6	speci$cally	speci$cally	ADV
aisthesis-3151	226	7	cytotoxic	cytotoxic	ADJ
aisthesis-3151	226	8	to	to	ADP
aisthesis-3151	226	9	renal	renal	ADJ
aisthesis-3151	226	10	cell	cell	NOUN
aisthesis-3151	226	11	carcinoma	carcinoma	NOUN
aisthesis-3151	226	12	(	(	PUNCT
aisthesis-3151	226	13	rcc	rcc	PROPN
aisthesis-3151	226	14	)	)	PUNCT
aisthesis-3151	226	15	cells	cell	NOUN
aisthesis-3151	226	16	can	can	AUX
aisthesis-3151	226	17	be	be	AUX
aisthesis-3151	226	18	isolated	isolate	VERB
aisthesis-3151	226	19	from	from	ADP
aisthesis-3151	226	20	patients	patient	NOUN
aisthesis-3151	226	21	with	with	ADP
aisthesis-3151	226	22	regressing	regress	VERB
aisthesis-3151	226	23	metastatic	metastatic	ADJ
aisthesis-3151	226	24	kidney	kidney	NOUN
aisthesis-3151	226	25	cancer	cancer	NOUN
aisthesis-3151	226	26	a&er	a&er	PROPN
aisthesis-3151	226	27	allogeneic	allogeneic	ADJ
aisthesis-3151	226	28	nonmyeloablative	nonmyeloablative	ADJ
aisthesis-3151	226	29	hematopoietic	hematopoietic	ADJ
aisthesis-3151	226	30	cell	cell	NOUN
aisthesis-3151	226	31	transplantation	transplantation	NOUN
aisthesis-3151	226	32	(	(	PUNCT
aisthesis-3151	226	33	nmhct	nmhct	NOUN
aisthesis-3151	226	34	)	)	PUNCT
aisthesis-3151	226	35	.	.	PUNCT
aisthesis-3151	227	1	blood	blood	NOUN
aisthesis-3151	227	2	,	,	PUNCT
aisthesis-3151	227	3	104(11	104(11	NUM
aisthesis-3151	227	4	)	)	PUNCT
aisthesis-3151	227	5	,	,	PUNCT
aisthesis-3151	227	6	4984	4984	NUM
aisthesis-3151	227	7	.	.	PUNCT
aisthesis-3151	228	1	#	#	NOUN
aisthesis-3151	228	2	ompson	ompson	NOUN
aisthesis-3151	228	3	,	,	PUNCT
aisthesis-3151	228	4	r.	r.	PROPN
aisthesis-3151	228	5	,	,	PUNCT
aisthesis-3151	228	6	kuntz	kuntz	PROPN
aisthesis-3151	228	7	,	,	PUNCT
aisthesis-3151	228	8	s.	s.	PROPN
aisthesis-3151	228	9	,	,	PUNCT
aisthesis-3151	228	10	leibovich	leibovich	PROPN
aisthesis-3151	228	11	,	,	PUNCT
aisthesis-3151	228	12	b.	b.	PROPN
aisthesis-3151	228	13	,	,	PUNCT
aisthesis-3151	228	14	dong	dong	PROPN
aisthesis-3151	228	15	,	,	PUNCT
aisthesis-3151	228	16	h.	h.	PROPN
aisthesis-3151	228	17	,	,	PUNCT
aisthesis-3151	228	18	lohse	lohse	PROPN
aisthesis-3151	228	19	,	,	PUNCT
aisthesis-3151	228	20	c.	c.	PROPN
aisthesis-3151	228	21	,	,	PUNCT
aisthesis-3151	228	22	webster	webster	PROPN
aisthesis-3151	228	23	,	,	PUNCT
aisthesis-3151	228	24	w.	w.	PROPN
aisthesis-3151	228	25	,	,	PUNCT
aisthesis-3151	228	26	.	.	PUNCT
aisthesis-3151	228	27	.	.	PUNCT
aisthesis-3151	228	28	.	.	PUNCT
aisthesis-3151	229	1	kwon	kwon	PROPN
aisthesis-3151	229	2	,	,	PUNCT
aisthesis-3151	229	3	e.	e.	PROPN
aisthesis-3151	229	4	(	(	PUNCT
aisthesis-3151	229	5	2006	2006	NUM
aisthesis-3151	229	6	)	)	PUNCT
aisthesis-3151	229	7	.	.	PUNCT
aisthesis-3151	230	1	tumor	tumor	NOUN
aisthesis-3151	230	2	b7	b7	PROPN
aisthesis-3151	230	3	-	-	PUNCT
aisthesis-3151	230	4	h1	h1	PROPN
aisthesis-3151	230	5	is	be	AUX
aisthesis-3151	230	6	associated	associate	VERB
aisthesis-3151	230	7	with	with	ADP
aisthesis-3151	230	8	poor	poor	ADJ
aisthesis-3151	230	9	prognosis	prognosis	NOUN
aisthesis-3151	230	10	in	in	ADP
aisthesis-3151	230	11	renal	renal	ADJ
aisthesis-3151	230	12	cell	cell	NOUN
aisthesis-3151	230	13	carcinoma	carcinoma	NOUN
aisthesis-3151	230	14	patients	patient	NOUN
aisthesis-3151	230	15	with	with	ADP
aisthesis-3151	230	16	long	long	ADJ
aisthesis-3151	230	17	-	-	PUNCT
aisthesis-3151	230	18	term	term	NOUN
aisthesis-3151	230	19	follow	follow	NOUN
aisthesis-3151	230	20	-	-	PUNCT
aisthesis-3151	230	21	up	up	NOUN
aisthesis-3151	230	22	.	.	PUNCT
aisthesis-3151	231	1	cancer	cancer	NOUN
aisthesis-3151	231	2	research	research	NOUN
aisthesis-3151	231	3	,	,	PUNCT
aisthesis-3151	231	4	66(7	66(7	NUM
aisthesis-3151	231	5	)	)	PUNCT
aisthesis-3151	231	6	,	,	PUNCT
aisthesis-3151	231	7	3381	3381	NUM
aisthesis-3151	231	8	-	-	SYM
aisthesis-3151	231	9	3385	3385	NUM
aisthesis-3151	231	10	.	.	PUNCT
aisthesis-3151	232	1	zhu	zhu	PROPN
aisthesis-3151	232	2	,	,	PUNCT
aisthesis-3151	232	3	j.	j.	PROPN
aisthesis-3151	232	4	,	,	PUNCT
aisthesis-3151	232	5	pabla	pabla	PROPN
aisthesis-3151	232	6	,	,	PUNCT
aisthesis-3151	232	7	s.	s.	PROPN
aisthesis-3151	232	8	,	,	PUNCT
aisthesis-3151	232	9	labriola	labriola	PROPN
aisthesis-3151	232	10	,	,	PUNCT
aisthesis-3151	232	11	m.	m.	NOUN
aisthesis-3151	232	12	,	,	PUNCT
aisthesis-3151	232	13	gupta	gupta	PROPN
aisthesis-3151	232	14	,	,	PUNCT
aisthesis-3151	232	15	r.	r.	PROPN
aisthesis-3151	232	16	t.	t.	PROPN
aisthesis-3151	232	17	,	,	PUNCT
aisthesis-3151	232	18	mccall	mccall	PROPN
aisthesis-3151	232	19	,	,	PUNCT
aisthesis-3151	232	20	s.	s.	PROPN
aisthesis-3151	232	21	,	,	PUNCT
aisthesis-3151	232	22	george	george	PROPN
aisthesis-3151	232	23	,	,	PUNCT
aisthesis-3151	232	24	d.	d.	PROPN
aisthesis-3151	232	25	j	j	PROPN
aisthesis-3151	232	26	…	…	PROPN
aisthesis-3151	232	27	.	.	PUNCT
aisthesis-3151	233	1	zhang	zhang	PROPN
aisthesis-3151	233	2	.	.	PUNCT
aisthesis-3151	234	1	t.	t.	PROPN
aisthesis-3151	234	2	(	(	PUNCT
aisthesis-3151	234	3	2019	2019	NUM
aisthesis-3151	234	4	)	)	PUNCT
aisthesis-3151	234	5	.	.	PUNCT
aisthesis-3151	235	1	evaluation	evaluation	NOUN
aisthesis-3151	235	2	of	of	ADP
aisthesis-3151	235	3	tumor	tumor	NOUN
aisthesis-3151	235	4	microenvironment	microenvironment	NOUN
aisthesis-3151	235	5	and	and	CCONJ
aisthesis-3151	235	6	biomarkers	biomarker	NOUN
aisthesis-3151	235	7	of	of	ADP
aisthesis-3151	235	8	immune	immune	ADJ
aisthesis-3151	235	9	checkpoint	checkpoint	NOUN
aisthesis-3151	235	10	inhibitor	inhibitor	NOUN
aisthesis-3151	235	11	(	(	PUNCT
aisthesis-3151	235	12	ici	ici	NOUN
aisthesis-3151	235	13	)	)	PUNCT
aisthesis-3151	235	14	response	response	NOUN
aisthesis-3151	235	15	in	in	ADP
aisthesis-3151	235	16	metastatic	metastatic	ADJ
aisthesis-3151	235	17	renal	renal	ADJ
aisthesis-3151	235	18	cell	cell	NOUN
aisthesis-3151	235	19	carcinoma	carcinoma	NOUN
aisthesis-3151	235	20	(	(	PUNCT
aisthesis-3151	235	21	mrcc	mrcc	NOUN
aisthesis-3151	235	22	)	)	PUNCT
aisthesis-3151	235	23	.	.	PUNCT
aisthesis-3151	236	1	journal	journal	NOUN
aisthesis-3151	236	2	of	of	ADP
aisthesis-3151	236	3	clinical	clinical	ADJ
aisthesis-3151	236	4	oncology	oncology	NOUN
aisthesis-3151	236	5	,	,	PUNCT
aisthesis-3151	236	6	37(8	37(8	NUM
aisthesis-3151	236	7	suppl	suppl	NOUN
aisthesis-3151	236	8	)	)	PUNCT
aisthesis-3151	236	9	,	,	PUNCT
aisthesis-3151	236	10	607	607	NUM
aisthesis-3151	236	11	.	.	NOUN
aisthesis-3151	236	12	8	8	NUM