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American Journal Of Agriculture And Horticulture Innovations  
(ISSN – 2771-2559) 
VOLUME 03 ISSUE 04     Pages: 29-36 

SJIF IMPACT FACTOR (2021: 5. 705) (2022: 5. 705) (2023: 7. 471)  
OCLC – 1290679216   

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 
Publisher: Oscar Publishing Services 

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ABSTRACT 

In this research work presented, the results obtained in the study of the general pharmacological properties of plant 

damalamari with anti-anemia activity, in particular, the effect on the an analysis of the literature on antimicrobial and 

pathogenic fungal activity was carried out. All the studies carried out were carried out in different animals, which 

serves to increase the reliability level and efficiency values of these experiments. Thus, a fresh decoction, developed 

on the basis of local medicinal plants, is less poisonous, it is from local tickling, cumulative and allergic effects. At the 

same time, the possibilities of applying the studied extract damalam against microbes and pathogenic fungi mainly in 

solution are being studied. The overall safety or non-toxicity of each biologically active substance is important for this 

reason, in this article we did not dwell in detail on its main activity. 

 

  Research Article 

 

ASSESSMENT OF THE ANTIBACTERIAL AND ANTI-FUNGAL ACTIVITY OF 

THE BIOLOGICALLY ACTIVE SUBSTANCE PREPARED FROM LOCAL PLANT 

EXTRACTS 
 

Submission Date: April 20, 2023, Accepted Date:  April 25, 2023,  

Published Date: April 30, 2023  

Crossref doi: https://doi.org/10.37547/ajahi/Volume03Issue04-06 

 

 

Bakhramova N.N. 
Tashkent Scientific Research Institute for vaccines and serums, Uzbekistan  

 

Abidova R.M. 
Tashkent Scientific Research Institute for vaccines and serums, Uzbekistan 

 

Ergashov O.I. 
Tashkent Scientific Research Institute for vaccines and serums, Uzbekistan 

 

Boymurodov B.T. 
Tashkent Scientific Research Institute for vaccines and serums, Uzbekistan 

 

Qalandarova F.S. 
Tashkent Scientific Research Institute for vaccines and serums, Uzbekistan    

 

Journal Website: 

https://theusajournals.

com/index.php/ajahi 

Copyright: Original 

content from this work 

may be used under the 

terms of the creative 

commons attributes 

4.0 licence. 

 

https://theusajournals.com
https://doi.org/10.37547/ajahi/Volume03Issue04-06


Volume 03 Issue 04-2023 30 

                 

 
 

   
  
 

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(ISSN – 2771-2559) 
VOLUME 03 ISSUE 04     Pages: 29-36 

SJIF IMPACT FACTOR (2021: 5. 705) (2022: 5. 705) (2023: 7. 471)  
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KEYWORDS 

General pharmacology plant extract, pathogenic fungal activity, skin resorption, allergic, tickling and cumulative 

properties. 

 

INTRODUCTION 

As you know, anemia is the main health problem, and 

this disease affects people of all ages, especially 

pregnant women and children. This cause anemia is 

one of the most common non-infectious diseases of 

expectant and lactating mothers to date, as well as in 

almost the entire segment of newborns. Around the 

world, various types of Genesis anemia are being 

suffered by residents in the greater scale area and 

regions, and this is widely seen as a serious health 

problem in nursing mothers. Ensuring the iron needs of 

residents of different young sexes is an important task 

that does not lose relevance. However, commonly 

used sources of synthetic iron cause complications, 

and modern prevention of iron deficiency anemia and 

pharmacotherapy of this pathology is primarily an 

urgent problem in the search and implementation of 

natural-structured substances [1-5]. According to 

statistics obtained on the basis of epidemiological 

studies conducted, about 42% of pregnant women 

worldwide and more than 47% of preschool children 

suffer from anemia. All types of anemia have serious 

adverse effects on human health and development, 

including neonatal and perinatal mortality, 

underweight, premature birth, and delayed infant 

development. Clinically, anemias are characterized by a 

variety of symptoms-notably pallor, fatigue, dizziness, 

difficulty breathing, shortness of breath, and 

weakness-and if not treated effectively, anemia 

contributes to cognitive decline, weakened immunity, 

and increased mortality [6-12]. A large-scale scientific 

research has been carried out in our country for many 

years to study the pharmaco-toxicological properties 

of extracts of plants or their biologically active 

substances. In particular, studies on the treatment of 

oncological diseases of plant alkaloids [14-18], the 

search for hepatoprotector agents based on plant 

flavonoids [19-23] at the same time, a number of 

advances have been made in the study of 

neuropsychopharmacological properties [24,25]. In 

this regard, as a direct continuation of the scientific 

research work carried out, the activity of plant extracts 

against anemia in research conditions with the aim of 

preventing and treating anemia of different etiologies 

and at different levels was studied [26]. Detection of 

organ and system hoardiness of extracts with anti-

anemia activity was found to study non-occurrence of 

side effects when chronically administered, as well as 

not exhibiting their skin resorption, allergy-inducing, 

and irritating properties. This article details the results 

of the study on the determination of the general 

pharmacological indicators described above. 

The purpose of the studies carried out is to:  

assessment of general pharmacological indicators of 

plant extracts with anti-anemia activity. 

Object and methods of research. As an object of 

research, a tincture of medicinal plants widely used in 

folk medicine was used: tubules of Hawthorn, Bird 

taron, sweet brain root, water pepper and medicinal 

chamomile plants, prepared in a 1:1 ratio. 



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VOLUME 03 ISSUE 04     Pages: 29-36 

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All studies carried out were carried out on a normal diet 

under vivarian conditions in rabbits with a body weight 

of 2-2.5 kg,sea urchins with a body weight of 500 - 600 

g, laboratory rats with a body weight of 180-200 g, and 

mice with a body weight of 18-24 g. 

The effect of the studied substance on the central 

nervous system was carried out in the “open field” 

method, the methods in which the skin resorption, 

tickling the mucous membranes and allergic properties 

are presented in the manuals and methodological 

recommendations [27]. 

1. The results obtained in the study of the local 

tickling property of the substance studied. 

The local tickling reaction of the tincture studied was 

studied in mice, rats and rabbits. To do this, a solution 

of various concentrations of the studied tincture was 

applied in doses of 0.25 - 0.5 ml to the skin of animals 

previously cleaned of feathers and instilled in one eye 

of rabbits from 2 - 3 drops, and in the other eye-in these 

conditions-discosted water was instilled. Control was 

recorded for 2 days. During this time, no reactions 

associated with visual tickling were recorded on the 

skin of animals or in the eyes of rabbits. 

2. The results of the study of the effect of the 

studied tincture on the activity of movement and 

search of experimental animals in the ‘open field’ 

method. 

In the studies carried out, it was demonstrated that 

this tincture did not adversely affect the activity of 

movement and search of experimental animals in 

relation to the control group in all doses studied. This, 

in turn, makes it possible to conclude that this tincture 

does not adversely affect the cognitive and motor 

activity of experimental animals, as well as impair the 

activity that requires attention. 

3. Assessment of the alaergic effect of the 

tincture studied 

To determine whether the studied tincture has an 

allergic effect, drip a solution of flour of various 

concentrations into the eyes of guinea pigs from 1 - 2 

drops, the effect of which on the mucous membrane 

of the eyes was monitored throughout the day. During 

the control, what changes in the mucous membrane of 

the animal eye in the experiment were not recorded. 

In subsequent experiments, the tincture made from 

the collection of plants was repeatedly applied to the 

skin of guinea pigs, which had previously been cleaned 

of wool. Experiments have shown that there are no 

changes characteristic of any apparent allergic 

reaction to the eye in the repeated drip site of this 

damalam: redness, rash, inflammation, skin peeling 

and other reactions that have not occurred. The 

general condition of the animals did not differ from the 

general condition of the animals in the control group.  

Then the allergic effect of tincture made from plant 

extracts in guinea pigs was studied using bull whey. For 

this, the animals in the experiment were sensitized 

with bull serum. On the 21st day of sensitization, a large 

dose of bull serum was administered to guinea pigs 

who had been doused with discarded water or 

tincture, and allergic reactions of almost the same 

appearance occurred in both groups of animals. In this, 

the breathing of animals was aggravated, sneezing 

appeared, the feathers snapped, and 3 of the 6 guinea 

pigs in both groups died. 

So it turns out that the studied damalam does not have 

the ability to bring an allergic reaction to the surface or 

prevent it. Taking into account the fact that several 

systems of the human body work on the occurrence of 

an allergic reaction, it is necessary to consider the 

results obtained in laboratory animals as relatively 



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American Journal Of Agriculture And Horticulture Innovations  
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Publisher: Oscar Publishing Services 

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relative results when assessing whether the newly 

studied collection has an allergic effect. 

4. Study of the cumulative effect of the herbal 

collection tincture under study. 

Cumulative effect of herbal decoction tincture under 

study 18 weight 140-170 g.li studied in labaratory rats. 

herbal collection tincture was administered orally on 

the first five days of the experiment in the amount of 5 

ml/kg. The next five days, however, the drug was 

administered with a 2-fold dose increase (10 ml/kg). 

Even in the 3rd and 4th five days of the experiment, the 

dose of BFC was administered in a volume that was 

increased 2 more times than in the previous 5-day dose, 

that is, in doses of 20 ml/kg and 40 ml/kg, respectively. 

For a total of 20 days, animals in the experimental 

group were administered an antianemic collection 

tincture – a herbal collection tincture, which was being 

studied at a dose of 375 ml/kg. 

The observation over the experiments was carried out 

during the entire experiment and for another 15 days 

after the last administered dose of the drug under 

vivarian conditions. The main focus in this was on the 

general condition of rats, their desire for food and 

response reactions to the various constituents given 

from the outside.  

The results were similar to those obtained in the 

control group of the general condition of animals, their 

desire for food, response reactions to external 

constituents.  

 The last observation from the experiment was made 

lifeless by animals on the 15th day against the 

background of mild narcosis, and their internal vital 

organinig morphological cases were considered. The 

tests carried out showed that the internal organs of the 

animals in the experiment did not have any changes.  

So, the plant collection under study does not cause any 

negative and side effects even when the herbal 

collection tincture is administered to animals in the 

experiment with a therapeutic dose of more than 15 

times its therapeutic dose for 20 days.  

Based on the above results, it can be said that herbal 

decoction is free from cumulative effects. 

5. Analysis of antimicrobial and pathogenic 

fungal activity of herbal tincture. 

In this section, based on the data of the studied and 

analyzed literature, preliminary results of the use of 

this extract of tincture for pathologies occurring on the 

skin and mucous membranes are presented [4,5, 28, 

29]. Preliminary analysis of extracts of various parts of 

of herbal tincture in various solvents for antimicrobial 

activity showed that only the root and leaves showed 

antibacterial activity. Antifungal activity was 

demonstrated by the root, fruits and seeds. These 

parts of the plant were taken for further study. The 

overall safety or non-toxicity of each biologically active 

substance is important for this reason, in this article we 

did not dwell in detail on its main activity. 

Conclusions. Medicinal plant tincture experimental 

animals were found to have no tickling effect on the 

skin and mucous membranes. Also, in the studies 

carried out, it did not show an allergic and cumulative 

nature, and it can be concluded that there is also no 

negative effect on the cognitive indicators of 

experimental animals, while in the same period of 

movement and search. 

Thus, a fresh decoction, developed on the basis of local 

medicinal plants, is less poisonous, it is from local 

tickling, cumulative and allergic effects. 

Preliminary analysis of extracts of various parts of of 

herbal tincture in various solvents for antimicrobial 



Volume 03 Issue 04-2023 33 

                 

 
 

   
  
 

American Journal Of Agriculture And Horticulture Innovations  
(ISSN – 2771-2559) 
VOLUME 03 ISSUE 04     Pages: 29-36 

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activity showed that only the root and leaves showed 

antibacterial activity. Antifungal activity was 

demonstrated by the root, fruits and seeds. These 

parts of the plant were taken for further study.  

The overall safety or non-toxicity of each biologically 

active substance is important for this reason, in this 

article we did not dwell in detail on its main activity. 

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lettuce. Int. J. Food Microbiol. 220, 6–18 (2016). 

29. Ashraf A. Mostafa , Abdulaziz A. Al-Askar , 

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Volume 03 Issue 04-2023 36 

                 

 
 

   
  
 

American Journal Of Agriculture And Horticulture Innovations  
(ISSN – 2771-2559) 
VOLUME 03 ISSUE 04     Pages: 29-36 

SJIF IMPACT FACTOR (2021: 5. 705) (2022: 5. 705) (2023: 7. 471)  
OCLC – 1290679216   

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 
Publisher: Oscar Publishing Services 

Servi 

Journal of Biological Sciences.  Volume 25, 

Issue 2, February 2018, Pages 361-366  

https://doi.org/10.1016/j.sjbs.2017.02.004  

 


