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American Journal Of Biomedical Science & Pharmaceutical Innovation    
(ISSN – 2771-2753) 
VOLUME 04 ISSUE 04 PAGES: 41-45 

SJIF IMPACT FACTOR (2022: 5. 705) (2023: 6.534) (2024: 7.7) 
OCLC – 1121105677     

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Publisher: Oscar Publishing Services 

Servi 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ABSTRACT 

Recent research in this area has shown that in many tissues, including skin, stem cells become dormant as they mature, 

slowing down their rate of division and not responding as effectively to stimulation [1]. A decrease in the activity of 

stem cells leads to the fact that the rate of skin renewal slows down and defects begin to accumulate in it; the skin 

ages [2]. Recently, the attention of scientists has been attracted by plant stem cells, which produce a complex of 

molecular regulators that are universal. These regulators are capable of changing the functioning of human skin stem 

cells, partially returning them the energy of youth [3]. One of the most popular ingredients today is Swiss apple stem 

cells. Each adult apple stem cell can independently generate new cells and, in a concentration of just 0.1%, stimulate 

the division of human stem cells by 80% [4]. Phytostem (plant) cells were discovered relatively recently - only in the 

second half of the 20th century [5]. And the most effective in influencing human cells are considered to be plant stem 

  Research Article 

 

EXPERIENCE OF USING STEM CELLS IN PATIENTS WITH ATOPIC 

DERMATITIS 
 

Submission Date: April 20, 2024, Accepted Date:  April 25, 2024,  

Published Date: April 30, 2024  

Crossref doi: https://doi.org/10.37547/ajbspi/Volume04Issue04-07 

 

 

I.S.Razikova  
Republican Scientifically Specialized Allergological Center, Tashkent, Uzbekistan 

 

N.P. Aidarova  
Republican Scientifically Specialized Allergological Center, Tashkent, Uzbekistan 

 

N.D. Dustbabaeva  
Center for Advanced Professional Qualifications of Medical Workers, Tashkent, Uzbekistan 

 

V.F. Baibekova  
Republican Scientifically Specialized Allergological Center, Tashkent, Uzbekistan 

 

Q.F.Nizamov  
Tashkent Medical Academy, Tashkent, Uzbekistan 

 

Journal Website: 

https://theusajournals.

com/index.php/ajbspi 

Copyright: Original 

content from this work 

may be used under the 

terms of the creative 

commons attributes 

4.0 licence. 

 

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Volume 04 Issue 04-2024 42 

                 

 
 

   
  
 

American Journal Of Biomedical Science & Pharmaceutical Innovation    
(ISSN – 2771-2753) 
VOLUME 04 ISSUE 04 PAGES: 41-45 

SJIF IMPACT FACTOR (2022: 5. 705) (2023: 6.534) (2024: 7.7) 
OCLC – 1121105677     

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Publisher: Oscar Publishing Services 

Servi 

cells, green apple phytostem cells. Scientists have proven that they are active biostimulators of human cells [6]. Plant 

cell preparations are absolutely hypoallergenic, unlike those obtained from animal or human tissues. 

KEYWORDS 

Atopic dermatitis, allergies, phytostem cells, food and household allergens. 

INTRODUCTION

Atopic dermatitis (AD) is a chronic, recurrent 

inflammatory skin disease with a complex 

pathogenesis, involving genetic predisposition, 

immunological and epidermal barrier dysfunction, and 

environmental factors [7]. The main symptom is 

pruritus; Skin lesions range from mild erythema to 

severe lichenification and erythroderma. A thorough 

history and narrow examinations are required to make 

a correct diagnosis. Treatment includes 

recommendations for proper skin care, avoidance of 

triggers, and topical use of corticosteroids and 

immunosuppressants. Treatment of itching and 

superinfections is also important. In severe cases, 

systemic immunosuppressive therapy may be required 

[8]. Atopic dermatitis that develops in childhood often 

regresses or its manifestations significantly weaken in 

adults [9]. 

For symptoms of atopic dermatitis, treatment and 

selection of the optimal way to combat the disease 

should be carried out under the supervision of a 

physician [10]. However, cell therapy in this case is 

most effective. This treatment method is characterized 

by a large number of advantages and allows to achieve 

the effect as quickly as possible without the 

development of any side effects or complications [11]. 

Stem cells primarily harmonize the activity of the 

immune system. And this ensures a significant 

reduction in the patient’s tendency to develop 

allergies. In addition, this method allows you to renew 

the cellular composition of all layers of the skin, which 

leads to minimizing the severity of external 

manifestations of dermatitis [12]. 

The purpose of the work was to study the clinical 

effectiveness of drugs containing stem cells of plant 

origin from Nabi-distribution. Two drugs from this 

manufacturer were studied: Cryoflora Nutra and Nutra 

stem cell. Cryoflora Nutra contains mulberry leaf 

extract, snow algae chlorophyll, and wheatgrass. 

Nutra stem cell contains apple and grape stem cells. 

Purpose of the study: to study the clinical effectiveness 

of drugs containing stem cells of plant origin from the 

«Nabi – distribution» company. Two drugs from this 

manufacturer Cryoflora were studied Nutra and Nutra 

stem cell . Cryoflora Nutra contains mulberry leaf 

extract, snow algae chlorophyll, and wheatgrass. 

Nutra stem cell contains apple and grape stem cells. 

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Volume 04 Issue 04-2024 43 

                 

 
 

   
  
 

American Journal Of Biomedical Science & Pharmaceutical Innovation    
(ISSN – 2771-2753) 
VOLUME 04 ISSUE 04 PAGES: 41-45 

SJIF IMPACT FACTOR (2022: 5. 705) (2023: 6.534) (2024: 7.7) 
OCLC – 1121105677     

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Publisher: Oscar Publishing Services 

Servi 

METHODS 

From May to September 2023, a clinical study was 

conducted on 40 patients with a verified diagnosis of 

atopic dermatitis of varying severity, aged 30-55 years. 

Of these, 15 are women, 25 are men. All patients 

provided written consent to participate in the study. 

Patients were prescribed Cryoflora Nutra 2 times a day 

and Nutra stem cell 1 time a day for 1 month. 

RESULTS 

All patients in the study group tolerated the therapy 

positively and reported no side effects. In 93% of 

patients, the acute course of the skin inflammatory 

process with atopic dermatitis tended to transition to 

subacute; 7% of patients did not note clinical 

improvement while taking these drugs. 

MATERIALS AND METHODS 

 From May to September 2023, a clinical study was 

carried out on 40 patients with a verified diagnosis of 

atopic dermatitis of varying severity, aged 30-55 years. 

Of these, 15 are women, 25 are men. All patients 

provided written consent to participate in the study. 

Patients were prescribed Cryoflora Nutra 2 times a day 

and Nutra stem cell 1 time a day for 1 month. 

Nutra stem cell contains Uttwiller apple stem cells 

Spatblauber Swiss apple - a rare type of apple from the 

18th century, capable of self-healing and great 

resilience. It was discovered by a team of scientists in 

Switzerland and later scientists successfully developed 

the Uttwiller Spatblauber Swiss apple stem cell. Unlike 

other types, Dettwiller Spatblauber Swiss apple stem 

cell has more energy. Studies have shown that  0.1% 

concentration of PhytoCellTec can activate and 

regenerate 80% of stem cells in the human body. It also 

contains grape stem cells from the rare Gamay grape 

variety Teinturier Fr. This grape variety comes from the 

Burgundy region of France and contains extremely 

high levels of anthocyanin, which is why the pulp and 

juice are red. It is rich in antioxidants that help protect 

the skin from free radicals generated by 

PhytoCellTecTM Solar Vitis grape stem cells protect the 

body's epithelial stem cells from aging. 

Cryoflora Nutra contains mulberry leaf extract, which 

has been used for medicinal purposes for many 

centuries. The benefits of mulberry leaves lie in their 

composition. The presence of vitamins and essential 

oils allows them to be used to treat many diseases. 

Mulberry leaf extract helps normalize heart tone, 

blood pressure and thin the blood. Also contains snow 

algae chlorophyll, which resembles the structure of 

blood and helps restore and replenish blood in the 

body. Rich in magnesium, which has an alkalizing effect 

on the body. Charges the body with energy and 

reduces fatigue. Removes toxins from the body that 

cause chronic diseases. Snow algae contains 

chlorophylls, which cleanse the gastrointestinal tract, 

improving digestion and absorption. 

Viagrass is an accelerated and effective cleansing of 

the body, removes toxins, oxidation products, and 

other waste. Thanks to the mineral enrichment of the 

body, the work of the endocrine and reproductive 

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Volume 04 Issue 04-2024 44 

                 

 
 

   
  
 

American Journal Of Biomedical Science & Pharmaceutical Innovation    
(ISSN – 2771-2753) 
VOLUME 04 ISSUE 04 PAGES: 41-45 

SJIF IMPACT FACTOR (2022: 5. 705) (2023: 6.534) (2024: 7.7) 
OCLC – 1121105677     

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Publisher: Oscar Publishing Services 

Servi 

systems is activated, the efficiency of the functioning 

of the kidneys, liver, and lungs increases. The 

hematopoietic process is also stabilized, the blood 

composition is treated antiseptically, and the transport 

function improves. 

RESULTS 

The effectiveness of therapy was assessed according 

to the following criteria: disappearance or reduction of 

skin manifestations using the SCORAD indicator. 

Studies have shown a significant decrease in the skin 

manifestations of AD: the frequency of papular-

erythematous rashes, dry skin, lichenification and 

excoriation. This is confirmed by a decrease in the 

SCORAD indicator (Fig. 1a). Thus, in the group of 

patients with AD during treatment, the index 

decreased by 2.4 times. 

 

   a        b 

Fig.1. Dynamics of changes in the SCORAD index 

(score) (a) and treatment effectiveness (b) in patients 

with atopic dermatitis during treatment. 

In patients with AD, incomplete remission was 

observed in 17.6%, complete remission was established 

in 78.9% of treated patients, and we observed no effect 

in 3.5% of patients 

Thus, the use of pathogenetic therapy with phytostem 

cells in patients with atopic dermatitis as part of a 

complex standard treatment made it possible to 

achieve an improvement in the clinical condition of 

patients.  

CONCLUSION 

Preparations containing stem cells of phyto origin  

Cryoflora Nutra and Nutra stem cell were well 

tolerated by all patients, no side effects were noted. 

These drugs can be used as pathogenetic anti-

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Volume 04 Issue 04-2024 45 

                 

 
 

   
  
 

American Journal Of Biomedical Science & Pharmaceutical Innovation    
(ISSN – 2771-2753) 
VOLUME 04 ISSUE 04 PAGES: 41-45 

SJIF IMPACT FACTOR (2022: 5. 705) (2023: 6.534) (2024: 7.7) 
OCLC – 1121105677     

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Publisher: Oscar Publishing Services 

Servi 

inflammatory therapy in the treatment of atopic 

dermatitis. 

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характеристика дермы кожи и ее изменения при 

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