







































Volume 04 Issue 05-2024 22 

                 

 
 

   
  
 

American Journal Of Biomedical Science & Pharmaceutical Innovation    
(ISSN – 2771-2753) 
VOLUME 04 ISSUE 05 PAGES: 22-28 

SJIF IMPACT FACTOR (2022: 5. 705) (2023: 6.534) (2024: 7.7) 
OCLC – 1121105677     

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Publisher: Oscar Publishing Services 

Servi 

 

 

 

 

 

 

 

 

 

 

 

ABSTRACT 

According to modern concepts, polypous sinusitis refers to diseases with a pronounced violation of the immunological 

reactivity¬of the body, the humoral component of which is still insufficiently studied. The inconsistency of the data 

presented in the literature regarding the content of immunoglobulins in patients with polypous sinusitis, the lack of 

clear¬data on their relationship with other indicators¬of organ resistance, especially in childhood, are the basis 

for¬further development of this issue. 

KEYWORDS 

Cutaneous-vascular¬reaction, duration index¬(ID), and character. 

INTRODUCTION

 This paper presents the results of a dynamic 

study of a number of indicators of humoral immunity in 

children suffering по¬from polyporous sinusitis. 

 The content of immunoglobulins of classes A, 

G, and M was determined by the radial 

immunodiffusion method с ис¬using monospecific 

  Research Article 

 

RESULTS OF SURGICAL TREATMENT OF PATIENTS WITH POLYPOUS 

FORMS OF SINUSITIS ACCORDING TO THE DATA CLINICAL-AND 

LABORATORY STUDIES 
 

Submission Date: May 16, 2024, Accepted Date:  May 21, 2024,  

Published Date: May 26, 2024  

Crossref doi: https://doi.org/10.37547/ajbspi/Volume04Issue05-05 

 

 

Rakhimov Zhakhongir Khotamovich 
Samarkand State Medical University, Uzbekistan 

 

Nasretdinova Makhzuna Takhsinovna 
Samarkand State Medical University, Uzbekistan 

 

Ulmasov Firdavs Gayratovich 
Samarkand State Medical University, Uzbekistan 

 

Journal Website: 

https://theusajournals.

com/index.php/ajbspi 

Copyright: Original 

content from this work 

may be used under the 

terms of the creative 

commons attributes 

4.0 licence. 

 

https://doi.org/10.37547/ajbspi/Volume03Issue03-01
https://scholar.google.co.in/scholar?q=
https://www.mendeley.com/search/?page=1&query=
https://theusajournals.com/
https://doi.org/10.37547/ajbspi/Volume04Issue05-05
https://theusajournals.com/index.php/ajbspi
https://theusajournals.com/index.php/ajbspi


Volume 04 Issue 05-2024 23 

                 

 
 

   
  
 

American Journal Of Biomedical Science & Pharmaceutical Innovation    
(ISSN – 2771-2753) 
VOLUME 04 ISSUE 05 PAGES: 22-28 

SJIF IMPACT FACTOR (2022: 5. 705) (2023: 6.534) (2024: 7.7) 
OCLC – 1121105677     

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Publisher: Oscar Publishing Services 

Servi 

sera, the concentration of magnesium in blood serum 

was determined by the fluorometric method, and the 

skin-vascular reaction (CSR) to histamine was studied, 

which¬was evaluated by three indicators: intensity, 

duration index¬(ID), and character. The intensity was 

expressed by the¬erythema diameter that occurred at 

the injection site of 0.01% histamine solution 5-minutes 

after scarification. The duration index was calculated 

as a percentage of the erythema diameter at 5 and 15 

minutes. Depending on the ID of the cutaneous-

vascular¬reaction, it was subdivided as follows. At ID, 

up to 40% of DAC¬was changed to normal, from 14 to 

80% — to slow, and more than 80% — to stagnant. In 

addition, the level of glycosaminoglycans in the blood 

serum was determined by the turbometric method. 

A total of 50 patients aged 18 to 35 years with polyp¬-

posal sinusitis were examined. In 22 patients, an 

edematous polyp was found in the general nasal 

passage¬, which occupied almost the entire half of the 

nasal cavity and often¬descended into the nasal 

pharynx. At the same time, there was no nasal 

breathing on the same side. In 28 patients, the polyps 

were significantly smaller, located in the nasal cavity, 

causing moderate difficulty in breathing. In 45 children, 

the polypous process was in the maxillary sinus, in 4-in 

the maxillary sinus and sinus of¬the ethmoid bone, in 

one child the polyps came from the sphenoid sinus 

(polypous form of sphenoiditis). Some patients 

reported head¬pain, general malaise, subfebrility, etc. 

A carefully collected allergic¬history revealed that 5 

patients had exudative diathesis and 4 had drug 

intolerance. Bronchopulmonary pathology (recurrent 

bronchitis, pneumonia, Cartagener's syndrome) was 

observed in 8 patients simultaneously with sinus 

involvement¬хит, пневмония, синдром Картагенера. 

Of the patients we examined, 13 patients had 

previously undergone polypotomy. However, most of 

them мес — 1 год отме¬had recurrent nasal polyposis 

after 3 months-1 year. 

To clarify the diagnosis, we used contrast X-

ray¬imaging, which allowed us to determine the 

location of the initial polyp growth and¬determine the 

scope of intervention. In 49 patients, a maxillary sinus 

was performed,4 of them simultaneously opened the 

cells of the sinus of the ethmoid bone and 1-the 

sphenoid sinus. Along with surgical intervention, as a 

rule, general strengthening and desensitizing 

treatment was performed¬. Children were examined in 

dynamics: at admission to the clinic and 1-2 years after 

surgery. Of the 50 operated patients, 44 had positive 

results, and 6 had a-recurrence of the disease. 

The results of the determination of serum 

immunoglobulins in the observed patientsare shown in 

Table 1. 

Table 1 

The content of immunoglobulins in blood serum in children 

with polypous sinusitis 

https://doi.org/10.37547/ajbspi/Volume03Issue03-01
https://scholar.google.co.in/scholar?q=
https://www.mendeley.com/search/?page=1&query=


Volume 04 Issue 05-2024 24 

                 

 
 

   
  
 

American Journal Of Biomedical Science & Pharmaceutical Innovation    
(ISSN – 2771-2753) 
VOLUME 04 ISSUE 05 PAGES: 22-28 

SJIF IMPACT FACTOR (2022: 5. 705) (2023: 6.534) (2024: 7.7) 
OCLC – 1121105677     

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Publisher: Oscar Publishing Services 

Servi 

 

 

 

 

 

 

 

 

 

 

 

From the data in Table 1, it can be seen that the average 

values of IgA and IgG concentrations in the group of 

patients were significantly lower than in the norm. 

 It should be noted that 

hypoimmunoglobulinemia is characteristic of¬most 

patients. The level of Ig M below normal was found in 

48 out of 50 patients¬, a Igand Ig A and Ig M — in 26. 

High levels of Ig A were observed only in 8 a children, 

and Ig G — in 6 children. 

 The results of the CSR test for histamine and 

the content of one of the components of the 

properdine system (magnesium) in the blood serum 

are presented in Table. 2. It is known that¬there is an 

inverse relationship between these indicators and they 

characterize the degree аллерги- of allergy of the 

body. 

 Table 2 shows that patientssuffering from 

полипозным polypous-sinusitisshowed a significant 

increase in the intensity of CSR, as well as an increase 

in the number of delayed reactions, which indicates 

insufficient histamine inactivation by 

histaminopexy.¬Despite the fact that the average 

values of magnesium content in the blood serum in 

patients did not differ from those in the control 

group,¬the distribution of magnesium content had a 

pronounced bimodality: in 23 out of 50 people, the 

magnesium level was below 0.75 mmol/l, in 7 — above 

1.05 mmol/l. In children of the control group, the 

distribution of magnesium content in the blood serum 

was singlemodal: in 90%¬of patients-0.78-1.05 mmol / l, 

i.e. within normal values. 

Table 2   

Data on the skin-vascular response to histamine and serum magnesium levels in patients, страдающих with 

polypous sinusitis 

Class of 

immunoglobulins 
Statistical indicator 

Content of immunoglobulins 

in in patients in in healthy 1 

Ig MAm+ m 94.8+9 128.4+5.6 
 n 50  

 t 302  

 P <0.05  

Ig G M+ m 105.2+13 200+9.9 

 n 50  

 t 5.8  

 P <0.05  

Ig M M+ m 113.9+7.3 129+6 

 n 50  

 t 1.6  

 P >0.05  

https://doi.org/10.37547/ajbspi/Volume03Issue03-01
https://scholar.google.co.in/scholar?q=
https://www.mendeley.com/search/?page=1&query=


Volume 04 Issue 05-2024 25 

                 

 
 

   
  
 

American Journal Of Biomedical Science & Pharmaceutical Innovation    
(ISSN – 2771-2753) 
VOLUME 04 ISSUE 05 PAGES: 22-28 

SJIF IMPACT FACTOR (2022: 5. 705) (2023: 6.534) (2024: 7.7) 
OCLC – 1121105677     

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Publisher: Oscar Publishing Services 

Servi 

Groups of examined 

patients 

andntensivity of 

KCP, mm 

Показатели CSR values for 

histamine, % Serum magnesium 

content, mmol/l nature of reactions 

normalные slowные 

Patients 14,8 ± 0 ,7 1 36 64 0,9+0,05 

Healthy 7,5±0,6 60 40 0,8±0,02 
Note. 1-information about the norm is given according to N. A. Kryukova and¬other authors, the difference in 

intensity is significant (P<0.01). 

Thus, the characteristic signs of allergization 

(low¬content of magnesium in the blood serum and 

increased concentration¬of histamine in the tissues 

against the background of its delayed inactivation) 

were detected in almost half of the sick children (the 

frequency of detection¬of these disorders was 0.46). 

This pattern was especially clearly observed in 

individuals (75%) with аллергизацииa history of allergy 

symptoms, which may¬be to some extent associated 

with a low concentration-цией Ig of Ig G.. 

 Recurrent polyposis was characterized by a 

decrease in the level of serum Ig A and Ig G (with a 

frequency of 0.71) and¬a violation of the exchange of 

glycosaminoglycanemia. Low production of class A and 

G immunoglobulins was noticed G(in 8 out of 10 

children with persistent relapsing process). Similar 

data are provided by V. I. Fedorich and N. V. Minin 

(1985), who studied the content of serum-

immunoglobulins in adults with polypous sinusitis. 

 In the long-term period (1-2 years after 

rehabilitation)¬, the immunological status of these 

children underwent the following changes:¬the 

content of Ig M decreased, the levels of Ig G and 

magnesium in¬the blood serum increased, and 

histamine metabolism significantly normalized.  

 The latter was reflected in a decrease in the 

intensity and duration index-of skin-vascular reactions. 

During these periods, examinations for¬slow CSR for 

histamine were detected in those who underwent 

surgery with almost the same frequency as in the 

control group (in 42% and 40%, respectively). Particular 

importance was attached to the nature of the 

dynamics¬of the analyzed indicators. The dynamics 

characterized by the aggravation of violations 

detected during the initial examination was considered 

negative¬, and the normalization or tendency to it of 

the corresponding indicators was considered positive. 

Positive dynamics in all indicators was noted in 40% of 

children, which, undoubtedly, can serve as an objective 

criterion for the effectiveness of the rehabilitation 

performed. Special attention should be paid to 

patients with negative dynamics¬of all indicators of 

humoral immunity. It should be emphasized that the 

results of their initial examination indicated a 

high¬degree of intensity of immunological processes. 

https://doi.org/10.37547/ajbspi/Volume03Issue03-01
https://scholar.google.co.in/scholar?q=
https://www.mendeley.com/search/?page=1&query=


Volume 04 Issue 05-2024 26 

                 

 
 

   
  
 

American Journal Of Biomedical Science & Pharmaceutical Innovation    
(ISSN – 2771-2753) 
VOLUME 04 ISSUE 05 PAGES: 22-28 

SJIF IMPACT FACTOR (2022: 5. 705) (2023: 6.534) (2024: 7.7) 
OCLC – 1121105677     

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Publisher: Oscar Publishing Services 

Servi 

 Here is an example of the data obtained during 

the examination of patient F., 18 years old. 

When the patient was admitted, the serum magnesium 

content was 1.05 mmol / l, a pronounced CSR for 

histamine was determined (the intensity of 17 mm ID is 

4.7), a low concentration of immunoglobulins (IgA-81.4 

IU / ml, IgG-95.2 IU / ml). 

7 months after the rehabilitation, there was a sharp 

decrease in the level of magnesium (up to 0.55 mmol/l), 

IgA (up to 20.3 IU/ml), IgG (up to 34.1 IU/ml) and 

complete areactivity according to the data of skin-

vascular reactions to histamine (intensity is 0, 

erythema is absent). In this case, we can probably 

speak of¬an immunological breakdown caused by an 

intervention performed against the background of a 

significant strain of immunological protection. 

 The determination of non-specific indicators 

of¬humoral immunity confirmed the concept of a 

number of researchers that the development of a 

chronic infectious and allergic process in the paranasal 

sinuses is associated with general autoimmune 

disorders¬and helps to clarify the relationship between 

the features of the immune¬response and the clinical 

manifestations of recurrent¬polyposis in children. The 

development of pronounced hyporeactivity in a 

number of patients may serve as a basis for 

measures¬aimed at stimulating general immunological 

resistance.¬A comprehensive dynamic study of the 

listed¬indicators of human immunity deserves 

attention as an objective criterion¬for the 

effectiveness of treatment of persons with polypous 

forms of sinusitis.  

It seems promising to further study the relationship 

between the increased concentration of serum GAGS, 

on the one hand, and excessive formation of polypous 

tissue in children, on the other, as well as between the 

low concentration of these structural components of 

connective tissue and the recurrent nature of the 

pathological process. 

You are a water user 

1. пациентов, страдающих полипозной формой 

синуитаThe¬content of serum immunoglobulins of 

classes A and G is reduced in patients suffering from 

the polypous form of sinusitis.G¬There is also a 

tendency for the Ig M level to decrease. М. 

2. Pronounced signs of allergy in the form of 

hypomagnesemia and altered skin-vascular reactions 

to histamine are detected in almost half of the 

examined patients. They were especially clearly 

observed in patients with a history of an allergic 

condition.  

3. The recurrence of the polypous process is 

characterized¬by a decrease in the concentration of 

GAG in the blood serum, and for excessive¬expansion 

of the polypous tissue-its increase.  

4. 1-2 years after the rehabilitation, 40% пациентов 

от¬of ot patients showed positive unidirectional 

dynamics of a number of indicators of humoral 

immunity (the level of magnesium and Ig G in blood 

serum), as well as skin and vascular reactions to 

https://doi.org/10.37547/ajbspi/Volume03Issue03-01
https://scholar.google.co.in/scholar?q=
https://www.mendeley.com/search/?page=1&query=


Volume 04 Issue 05-2024 27 

                 

 
 

   
  
 

American Journal Of Biomedical Science & Pharmaceutical Innovation    
(ISSN – 2771-2753) 
VOLUME 04 ISSUE 05 PAGES: 22-28 

SJIF IMPACT FACTOR (2022: 5. 705) (2023: 6.534) (2024: 7.7) 
OCLC – 1121105677     

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Publisher: Oscar Publishing Services 

Servi 

histamine, indicating increased immunological 

protection of the body. 

REFERENCES 

1. Lund VJ, Howard D, Wei W. Tumours of the nose, 

sinuses and nasopharynx. Thieme 2014;1–595  

2. Edge SB, Compton CC, Fritz AG, Greene FL, Trotti A. 

AJCC Cancer Staging Manual, 7th edn. New York: 

Springer, 2010  

3. Dragonetti A, Gera R, Sciuto A, Scotti A, Bigoni A, 

Barbaro E et al. Sinonasal inverted papilloma: 84 

patients treated by endoscopy and proposal for a 

new classification. Rhinology 2011;49:207–13  

4. Nicolai P, Berlucchi M, Tomenzoli D, Cappiello J, 

Trimarchi M, Maroldi R et al. Endoscopic surgery 

for juvenile angiofibroma: when and how. 

Laryngoscope 2003;113:775–82  

5. Ganly I, Patel SG, Singh B, Kraus DH, Bridger PG, 

Cantu G et al. Craniofacial resection for malignant 

paranasal sinus tumors: report of an international 

collaborative study. Head Neck 2005;27:575–84  

6. Snyderman CH, Carrau RL, Kassam AB, Zanation A, 

Prevedello D, Gardner P et al. Endoscopic skull base 

surgery: principles of endonasal oncological 

surgery. J Surg Oncol 2008;97:658–64  

7. Lund V, Stammberger H, Nicolai P, Castelnuovo P, 

Beal T, Beham A et al. European position paper on 

endoscopic management of the nose, paranasal 

sinuses and skull base. Rhinol Suppl 2010;22:1–144  

8. Lund V, Wei W. Endoscopic resection of malignant 

sinonasal tumors: an eighteen year experience. 

Rhinology 2015;40:407–11  

9. Nicolai P, Battaglia P, Bignami M, Bolzoni Villaret A, 

Delu G, Khrais T et al. Endoscopic surgery for 

malignant tumors of the sinonasal tract and 

adjacent skull base: a 10-year experience. Am J 

Rhinol 2008;22:308–16 

10. Eloy J, Vivero R, Hoang K, Civantos FJ, Weed DT, 

Morcos JJ et al. Comparison of transnasal 

endoscopic and open craniofacial resection for 

malignant tumors of the anterior skull base. 

Laryngoscope 2009;119:834–40  

11. Batra P, Luong A, Kanowitz SJ, Sade B, Lee J, Lanza 

DC et al. Outcomes of minimally invasive 

endoscopic resection of anterior skull base 

neoplasms. Laryngoscope 2010;120:9–16  

12. Devaiah AK, Andreoli MT. Treatment of 

esthesioneuroblastoma: a 16-year meta-analysis of 

361 patients. Laryngoscope 2009;119:1412–16  

13. Rimmer J, Lund V, Beale T, Howard D, Wei W. 

Olfactory neuroblastoma – a 35 year experience 

and suggested follow-up protocol, Laryngoscope 

2014;124:1542–49  

14. Lund VJ, Chisholm EJ, Howard DJ, Wei WI. 

Sinonasal melanoma: a review of 115 cases 

assessing outcomes of surgery, postoperative 

radiotherapy and endoscopic resection. Rhinology 

2012;50:203–10  

https://doi.org/10.37547/ajbspi/Volume03Issue03-01
https://scholar.google.co.in/scholar?q=
https://www.mendeley.com/search/?page=1&query=


Volume 04 Issue 05-2024 28 

                 

 
 

   
  
 

American Journal Of Biomedical Science & Pharmaceutical Innovation    
(ISSN – 2771-2753) 
VOLUME 04 ISSUE 05 PAGES: 22-28 

SJIF IMPACT FACTOR (2022: 5. 705) (2023: 6.534) (2024: 7.7) 
OCLC – 1121105677     

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Publisher: Oscar Publishing Services 

Servi 

15. Zanation A, Ferlito A, Rinaldo A, Gore M, Lund V, 

Mckinney K et al. When, how and why to treat the 

neck in patients with esthesioneuroblastoma: a 

review. Eur Arch ORL 2010;267:1667–71  

16. Ang KK, Garden AS. Radiotherapy for Head and 

Neck Cancer: Indications and Techniques, 3rd edn. 

Lippincott, 2006  

17. Shakhanova Sh. Sh., Rakhimov M. N. Aspects of 

sarcopenia syndrome in oncological  practice:  

diagnosis  and  treatment  (literature  review) //  

Journal  of  Biomedicine  and Practice. 2023, vol. 8, 

issue 3, pp. 406-417 

18. 18.Rakhimov M. N., Tulanov T. B., Shakhanova Sh. 

Sh., Aslsnova M. L. Pathogenetic aspects of cancer 

anorexia// Journal of Biomedicine and Practice. 

2023, vol. 8, issue 4, pp.192-201 

19. Dirix P, Vanstraelen B, Jorissen M, Vander Poorten 

V, Nuyts S. Intensity-modulated radiotherapy for 

sinonasal cancer: improved outcome compared to 

conventional radiotherapy. Int J Radiat Oncol Biol 

Phys 2010;78:998–1004  

20. Shakhanova Sh. Sh., Rakhimov N. M., & Murodov 

Sh. T.. (2024). Aspects of sarcopenia syndrome in 

oncological practice: diagnosis and treatment. The 

American Journal of Medical Sciences and 

Pharmaceutical Research, 6(02), 16–25. 

https://doi.org/10.37547/TAJMSPR/Volume06Issue

02-03 

21. Bristol IJ, Ahamad A, Garden AS, Morrison WH, 

Hanna EY, Papadimitrakopoulou VA et al. 

Postoperative radiotherapy for maxillary sinus 

cancer: long term outcomes and toxicities of 

treatment. Int J Radiat Oncol Biol Phys 

2007;68:719–30  

22. Brasnu D, Laccourreye O, Bassot V, Laccourreye L, 

Naudo P, Roux FX. Cisplatin-based neoadjuvant 

chemotherapy and combined resection for 

ethmoid sinus adenocarcinoma reaching and/or 

invading the skull base. Arch Otolaryngol Head 

Neck Surg 1996;122:765–68  

23. 20. Dulguerov P, Allal AS. Nasal and paranasal sinus 

carcinoma: how can we continue to make 

progress? Curr Opin Otolaryngol Head Neck Surg 

2006;14:67–72  

 

 

https://doi.org/10.37547/ajbspi/Volume03Issue03-01
https://scholar.google.co.in/scholar?q=
https://www.mendeley.com/search/?page=1&query=

