







































Volume 04 Issue 11-2024 31 

                 

 
 

   
  
 

American Journal Of Biomedical Science & Pharmaceutical Innovation    
(ISSN – 2771-2753) 
VOLUME 04 ISSUE 11 PAGES: 31-35 

OCLC – 1121105677     

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Publisher: Oscar Publishing Services 

Servi 

 

 

 

 

 

 

 

 

 

 

 

ABSTRACT 

The article presents the clinical experience of diode laser application in the complex treatment of exfoliative cheilitis 

in patients with coronavirus infection. It was found that a more pronounced anti-inflammatory effect was noted in the 

patients of the main group, where the diode laser was included in the treatment scheme, which is expressed in the 

elimination of the inflammatory reaction of the mucous membrane in a shorter time than in the patients of the control 

group. 

The study showed that the use of diode laser helps stimulate the regeneration of the mucous membrane in the lesion 

and can significantly improve the effectiveness of complex therapy, which is reflected in reduced pain, accelerated 

epithelialization, increased duration of remission and reducing the number of relapses. 

 

KEYWORDS 

exfoliative cheilitis, diode laser, new coronavirus infection COVID-19. 

  Research Article 

 

NEW APPROACHES IN COMPREHENSIVE TREATMENT OF CHEILITIS IN 

PATIENTS WHO HAVE SURVIVED CORONAVIRUS INFECTION 
 

Submission Date: October 29, 2024, Accepted Date:  November 03, 2024,  

Published Date: November 30, 2024  

Crossref doi: https://doi.org/10.37547/ajbspi/Volume04Issue11-05 

 

 

Toshtemirova Mokhira Makhmud kizi 
Samarkand State Medical University, Uzbekistan 

 

Jurakulov Abbos G’ofurovich 
Assistant of the Department of Therapeutic Dentistry, Uzbekistan 

 

Sirliboyeva Iqbol Murod qizi 
Samarkand State Medical University, Uzbekistan 

Journal Website: 

https://theusajournals.

com/index.php/ajbspi 

Copyright: Original 

content from this work 

may be used under the 

terms of the creative 

commons attributes 

4.0 licence. 

 

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Volume 04 Issue 11-2024 32 

                 

 
 

   
  
 

American Journal Of Biomedical Science & Pharmaceutical Innovation    
(ISSN – 2771-2753) 
VOLUME 04 ISSUE 11 PAGES: 31-35 

OCLC – 1121105677     

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Publisher: Oscar Publishing Services 

Servi 

INTRODUCTION

A large number of studies conducted around the world 

over the past two years have shown that due to the 

spread of the new coronavirus infection, the number 

of diseases of the oral mucosa caused by COVID-19 is 

steadily increasing. Coronavirus can cause not only 

pneumonia, but also affect the mucous membrane of 

the oral cavity. 

The pathogenic agent enters the body thanks to 

angiotensin-converting enzyme 2, which is localized 

both on the surface of the alveoli and pulmonary 

structures, and on the epithelial cells of the oral cavity, 

where it begins to actively multiply. There are 

publications in the literature that more than 80% of 

patients who have suffered coronavirus infection note 

changes in the oral mucosa in the form of dryness and 

damage to the lips. 

Xerostomia can be caused both by taking medications 

and by the influence of aggravated systemic diseases. 

More than 500 medications can cause xerostomia. 

According to researchers, post-Covid syndrome is a 

fairly broad diagnosis with psychophysiological 

consequences. A separate code has appeared in ICD-10 

to describe post-Covid syndrome (U09.9). 

Psycho-emotional disturbances (usually in the form of 

increased personal anxiety, sleep disorders, anger, 

autonomic disorders, asthenic syndrome with 

emotional lability), which occurs against the 

background of the COVID-19 pandemic, significantly 

affect not only the quality of life of patients who have 

had COVID-19, but and is a predictor of disease. In this 

connection, the dynamics of the occurrence and 

development of diseases, in the etiology of which the 

main factor is neurogenic nature, is increasing. Such 

diseases include cheilitis. According to domestic and 

foreign literature, lip diseases are relatively common 

and are an important problem in modern dentistry, 

since their diagnosis poses significant difficulties, and 

the treatment of this pathology is not always 

successful. 

The most common are inflammatory and destructive 

diseases, such as meteorological, exfoliative, actinic 

cheilitis and chronic lip fissures. Being under the 

constant influence of external and internal factors, the 

red border of the lips is the site of manifestation of 

various diseases, including dermatoses. In addition, the 

mucous membrane of the red border of the lips can be 

subject to all sorts of inflammatory processes, 

undergoing various transformations, which, in turn, 

leads to significant difficulties in making a diagnosis. 

Exfoliative cheilitis K13.0 is a chronic disease of the red 

border of the lips, characterized by a complex and not 

fully understood etiopathogenesis, a variety of trigger 

factors and the often insufficient effect of the therapy 

used. Exfoliative cheilitis was first described in 1922. by 

French scientists Mikulic and Kümmel as “persistent 

peeling of the lips.” 

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Volume 04 Issue 11-2024 33 

                 

 
 

   
  
 

American Journal Of Biomedical Science & Pharmaceutical Innovation    
(ISSN – 2771-2753) 
VOLUME 04 ISSUE 11 PAGES: 31-35 

OCLC – 1121105677     

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Publisher: Oscar Publishing Services 

Servi 

Most researchers believe that neurogenic factors 

underlie the disease. Patients suffering from it 

experience a more or less significant functional 

disorder of the nervous system. Various allergens, both 

endogenous and exogenous, can also be factors that 

support and aggravate the disease. In patients with 

exfoliative cheilitis, various types of psycho-emotional 

disorders, anxiety reactions, and depressive states 

have been identified. There is evidence of the possible 

role of immunological factors in the pathogenesis of 

the disease. 

In addition, the presence of dry mucous membranes 

and a decrease in the amount of saliva affects the 

development of the disease, since in this case the 

balance of oral microorganisms is disrupted. Patients 

lick their lips more often, resulting in a red border of 

the lips cracks and peels. The disease negatively affects 

the aesthetic qualities of the patient, leading to serious 

psychological and social disorders due to cosmetic 

defects. Treatment of lip diseases is one of the difficult 

tasks of modern dentistry. 

Based on an analysis of literature sources by domestic 

and foreign authors devoted to the study of the 

condition of the red border of the lips and treatment 

methods, it can be concluded that existing approaches 

to the treatment of this pathology are not effective 

enough. Despite advances in pharmacology, the 

effectiveness of most drugs and treatment methods 

remains unsatisfactory. 

Currently, there is no single universal approach to the 

treatment of cheilitis and most existing methods have 

a temporary positive effect. In addition, post-Covid 

cheilitis is particularly resistant to therapy and has a 

long course. Therefore, it is urgent to search for new 

methods of treating exfoliative cheilitis that are highly 

effective with the least possibility of 

complications.This raises the need for further research 

to optimize the treatment of lip diseases. At the 

moment, one of the modern trends is the use of laser 

technologies. The purpose of the study is to increase 

the effectiveness of complex treatment of patients 

with exfoliative cheilitis who have had COVID-19 

infection by including a diode laser in the treatment 

regimen. 

Research objectives:  

1. To study the effect of a diode laser on reducing the 

intensity of pain sensitivity in patients with exfoliative 

cheilitis. 

 2. To study the effect of a diode laser on the timing of 

mucosal regeneration in patients with exfoliative 

cheilitis.  

MATERIAL AND METHODS 

To achieve this goal, 21 patients aged 22 to 55 years 

who had COVID-19 over the past 6 months with a 

diagnosis of exfoliative cheilitis K13.0 were examined. 

All examined patients were randomized into 2 groups: 

the main group consisted of 10 patients, the control 

group - 11. All patients had 

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Volume 04 Issue 11-2024 34 

                 

 
 

   
  
 

American Journal Of Biomedical Science & Pharmaceutical Innovation    
(ISSN – 2771-2753) 
VOLUME 04 ISSUE 11 PAGES: 31-35 

OCLC – 1121105677     

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Publisher: Oscar Publishing Services 

Servi 

The study noted complaints of increased lip size, a 

burning sensation, pain when closing the lips, difficulty 

eating, dry mouth, and an unpleasant aesthetic 

appearance. The red border of the lips is brightly 

hyperemic with individual white-honey-colored scales, 

the mouth is slightly open. 

The clinical picture corresponded to the diagnosis of 

K13.0. Pain intensity was assessed on a verbal scale 

before and 24 hours after treatment. When analyzing 

the dental status of patients, a high value of the 

simplified hygiene index OHI-S was revealed: 2.81±0.22 

in the main group and 2.78±0.23 in the control groups. 

When assessing the factors of unsatisfactory oral 

hygiene from the anamnesis, it was noted that the 

main reasons are the impossibility and difficulty of 

brushing teeth due to the irritating effect of hygiene 

products on inflamed and eroded areas. All patients 

underwent traditional complex treatment, including 

sanitation of the mouth, administration of keratoplasty 

ointments, and the use of hygienic lipsticks. When 

various changes in the nervous system were detected, 

sedatives were prescribed together with a neurologist 

or psychotherapist. In addition, the patients of the 

main group received a diode laser from Dr. SMILE 

(Italy), wavelength 980 nm, procedure power 0.7 W, in 

continuous mode, in a distant technique, with a non-

initiated fiber for 1 min. on a lesion area of 1 sq. cm., 

three times, after 2 days. 

RESEARCH RESULTS 

One day after treatment, all patients in the main group 

noted a decrease in pain (pain intensity decreased from 

5.2±0.2 before treatment to 0.18±0.12 (p<0.05)); in 

patients in the control group, pain intensity decreased 

from 5.4±0.3 to 2.9±0.16 (p>0.05). 

On the 3rd day after treatment, patients in the main 

group experienced a pronounced therapeutic effect, 

which was manifested in a decrease or complete 

disappearance of the feeling of tightness and 

roughness of the lips, a decrease in the intensity of 

inflammation, active epithelization of the mucous 

membrane, a decrease in pain and discomfort. On the 

10th day after treatment, OHI-S in the main group was 

0.61±0.22, in the control group 1.1±0.24. 

Complete epithelization of elements in the main group 

was observed after 14 days, while in the control group 

recovery occurred on average 21 days after the start of 

treatment. The insignificant effect of the treatment in 

the control group contributed to the formation of a 

negative psychological attitude towards further 

therapy. 

CONCLUSIONS 

1. It was found that a more pronounced decrease in 

pain sensitivity was observed in patients of the main 

group, where a diode laser was included in the 

treatment regimen. 

2. The study showed that the use of laser helped 

stimulate the regeneration of the mucous membrane 

in the lesions. The period of final epithelization of 

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Volume 04 Issue 11-2024 35 

                 

 
 

   
  
 

American Journal Of Biomedical Science & Pharmaceutical Innovation    
(ISSN – 2771-2753) 
VOLUME 04 ISSUE 11 PAGES: 31-35 

OCLC – 1121105677     

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Publisher: Oscar Publishing Services 

Servi 

elements in the main group was 14 days, in the control 

group - 21 days. 

3. The inclusion of a diode laser in the treatment 

regimen for patients with cheilitis is justified and can 

significantly increase the effectiveness of complex 

therapy, which is expressed in reducing pain, 

accelerating epithelialization, increasing the duration 

of remission and reducing the number of relapses. 

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E.V.Pupykina, I.V.Romeiko//National Association of 

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- pp. 37-38 

2. Belotserkovskaya Yu.G., Romanovskikh A.G., 

Smirnov I.P. COVID-19: Respiratory infection 

caused by a new coronavirus: new data on 

epidemiology, clinical course, patient management 

// Consilium Medicum. 2020. - No. 3. - P. 12-20. 

3. Qizi, T. M. M., & Ugli, Y. S. M. (2023). IMPROVING 

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DENTAL STATUS IN ELDERLY AND SENILE PEOPLE 

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4. Turaqulov, O., Umrullaeva, J., Zoyirov, T., & 

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