id	sid	tid	token	lemma	pos
ajbspi-134509	1	1	american	american	PROPN
ajbspi-134509	1	2	journal	journal	PROPN
ajbspi-134509	1	3	of	of	ADP
ajbspi-134509	1	4	biomedical	biomedical	PROPN
ajbspi-134509	1	5	science	science	PROPN
ajbspi-134509	1	6	&	&	CCONJ
ajbspi-134509	1	7	pharmaceutical	pharmaceutical	NOUN
ajbspi-134509	1	8	innovation	innovation	NOUN
ajbspi-134509	1	9	1	1	NUM
ajbspi-134509	1	10	https://theusajournals.com/index.php/ajbspi	https://theusajournals.com/index.php/ajbspi	NOUN
ajbspi-134509	1	11	volume	volume	NOUN
ajbspi-134509	1	12	vol.05	vol.05	NOUN
ajbspi-134509	1	13	issue08	issue08	NOUN
ajbspi-134509	1	14	2025	2025	NUM
ajbspi-134509	1	15	page	page	NOUN
ajbspi-134509	1	16	no	no	INTJ
ajbspi-134509	1	17	.	.	NOUN
ajbspi-134509	2	1	1	1	NUM
ajbspi-134509	2	2	-	-	SYM
ajbspi-134509	2	3	8	8	NUM
ajbspi-134509	2	4	microbial	microbial	ADJ
ajbspi-134509	2	5	exploitation	exploitation	NOUN
ajbspi-134509	2	6	of	of	ADP
ajbspi-134509	2	7	host	host	NOUN
ajbspi-134509	2	8	purinergic	purinergic	NOUN
ajbspi-134509	2	9	signaling	signal	VERB
ajbspi-134509	2	10	:	:	PUNCT
ajbspi-134509	2	11	unraveling	unravel	VERB
ajbspi-134509	2	12	clostridioides	clostridioide	NOUN
ajbspi-134509	2	13	difficile	difficile	VERB
ajbspi-134509	2	14	's	's	PART
ajbspi-134509	2	15	influence	influence	NOUN
ajbspi-134509	2	16	on	on	ADP
ajbspi-134509	2	17	adenosine	adenosine	ADJ
ajbspi-134509	2	18	homeostasis	homeostasis	NOUN
ajbspi-134509	2	19	dr	dr	PROPN
ajbspi-134509	2	20	.	.	PROPN
ajbspi-134509	2	21	anjali	anjali	PROPN
ajbspi-134509	2	22	p.	p.	PROPN
ajbspi-134509	2	23	mehta	mehta	PROPN
ajbspi-134509	2	24	division	division	NOUN
ajbspi-134509	2	25	of	of	ADP
ajbspi-134509	2	26	molecular	molecular	ADJ
ajbspi-134509	2	27	medicine	medicine	NOUN
ajbspi-134509	2	28	,	,	PUNCT
ajbspi-134509	2	29	all	all	DET
ajbspi-134509	2	30	india	india	PROPN
ajbspi-134509	2	31	institute	institute	PROPN
ajbspi-134509	2	32	of	of	ADP
ajbspi-134509	2	33	medical	medical	PROPN
ajbspi-134509	2	34	sciences	sciences	PROPN
ajbspi-134509	2	35	(	(	PUNCT
ajbspi-134509	2	36	aiims	aiims	PROPN
ajbspi-134509	2	37	)	)	PUNCT
ajbspi-134509	2	38	,	,	PUNCT
ajbspi-134509	2	39	new	new	PROPN
ajbspi-134509	2	40	delhi	delhi	PROPN
ajbspi-134509	2	41	,	,	PUNCT
ajbspi-134509	2	42	india	india	PROPN
ajbspi-134509	2	43	dr	dr	PROPN
ajbspi-134509	2	44	.	.	PROPN
ajbspi-134509	2	45	mark	mark	PROPN
ajbspi-134509	2	46	j.	j.	PROPN
ajbspi-134509	2	47	thompson	thompson	PROPN
ajbspi-134509	2	48	department	department	PROPN
ajbspi-134509	2	49	of	of	ADP
ajbspi-134509	2	50	pathobiology	pathobiology	NOUN
ajbspi-134509	2	51	,	,	PUNCT
ajbspi-134509	2	52	university	university	PROPN
ajbspi-134509	2	53	of	of	ADP
ajbspi-134509	2	54	pennsylvania	pennsylvania	PROPN
ajbspi-134509	2	55	perelman	perelman	PROPN
ajbspi-134509	2	56	school	school	PROPN
ajbspi-134509	2	57	of	of	ADP
ajbspi-134509	2	58	medicine	medicine	NOUN
ajbspi-134509	2	59	,	,	PUNCT
ajbspi-134509	2	60	philadelphia	philadelphia	PROPN
ajbspi-134509	2	61	,	,	PUNCT
ajbspi-134509	2	62	pa	pa	PROPN
ajbspi-134509	2	63	,	,	PUNCT
ajbspi-134509	2	64	usa	usa	PROPN
ajbspi-134509	2	65	received	receive	VERB
ajbspi-134509	2	66	:	:	PUNCT
ajbspi-134509	2	67	03	03	NUM
ajbspi-134509	2	68	june	june	PROPN
ajbspi-134509	2	69	2025	2025	NUM
ajbspi-134509	2	70	;	;	PUNCT
ajbspi-134509	2	71	accepted	accept	VERB
ajbspi-134509	2	72	:	:	PUNCT
ajbspi-134509	2	73	02	02	NUM
ajbspi-134509	2	74	july	july	PROPN
ajbspi-134509	2	75	2025	2025	NUM
ajbspi-134509	2	76	;	;	PUNCT
ajbspi-134509	2	77	published	publish	VERB
ajbspi-134509	2	78	:	:	PUNCT
ajbspi-134509	2	79	01	01	NUM
ajbspi-134509	2	80	august	august	PROPN
ajbspi-134509	2	81	2025	2025	NUM
ajbspi-134509	2	82	abstract	abstract	NOUN
ajbspi-134509	2	83	:	:	PUNCT
ajbspi-134509	2	84	clostridioides	clostridioide	NOUN
ajbspi-134509	2	85	difficile	difficile	VERB
ajbspi-134509	2	86	is	be	AUX
ajbspi-134509	2	87	a	a	DET
ajbspi-134509	2	88	prominent	prominent	ADJ
ajbspi-134509	2	89	pathogen	pathogen	NOUN
ajbspi-134509	2	90	responsible	responsible	ADJ
ajbspi-134509	2	91	for	for	ADP
ajbspi-134509	2	92	severe	severe	ADJ
ajbspi-134509	2	93	gastrointestinal	gastrointestinal	ADJ
ajbspi-134509	2	94	infections	infection	NOUN
ajbspi-134509	2	95	,	,	PUNCT
ajbspi-134509	2	96	with	with	ADP
ajbspi-134509	2	97	its	its	PRON
ajbspi-134509	2	98	pathogenicity	pathogenicity	NOUN
ajbspi-134509	2	99	intricately	intricately	ADV
ajbspi-134509	2	100	linked	link	VERB
ajbspi-134509	2	101	to	to	ADP
ajbspi-134509	2	102	interactions	interaction	NOUN
ajbspi-134509	2	103	with	with	ADP
ajbspi-134509	2	104	host	host	NOUN
ajbspi-134509	2	105	cellular	cellular	ADJ
ajbspi-134509	2	106	mechanisms	mechanism	NOUN
ajbspi-134509	2	107	.	.	PUNCT
ajbspi-134509	3	1	this	this	DET
ajbspi-134509	3	2	study	study	NOUN
ajbspi-134509	3	3	explores	explore	VERB
ajbspi-134509	3	4	how	how	SCONJ
ajbspi-134509	3	5	c.	c.	NOUN
ajbspi-134509	3	6	difficile	difficile	NOUN
ajbspi-134509	3	7	exploits	exploit	VERB
ajbspi-134509	3	8	host	host	NOUN
ajbspi-134509	3	9	purinergic	purinergic	NOUN
ajbspi-134509	3	10	signaling	signal	VERB
ajbspi-134509	3	11	pathways	pathway	NOUN
ajbspi-134509	3	12	,	,	PUNCT
ajbspi-134509	3	13	particularly	particularly	ADV
ajbspi-134509	3	14	focusing	focus	VERB
ajbspi-134509	3	15	on	on	ADP
ajbspi-134509	3	16	its	its	PRON
ajbspi-134509	3	17	impact	impact	NOUN
ajbspi-134509	3	18	on	on	ADP
ajbspi-134509	3	19	adenosine	adenosine	ADJ
ajbspi-134509	3	20	homeostasis	homeostasis	NOUN
ajbspi-134509	3	21	.	.	PUNCT
ajbspi-134509	4	1	adenosine	adenosine	NOUN
ajbspi-134509	4	2	,	,	PUNCT
ajbspi-134509	4	3	a	a	DET
ajbspi-134509	4	4	critical	critical	ADJ
ajbspi-134509	4	5	immunomodulatory	immunomodulatory	ADJ
ajbspi-134509	4	6	molecule	molecule	NOUN
ajbspi-134509	4	7	,	,	PUNCT
ajbspi-134509	4	8	plays	play	VERB
ajbspi-134509	4	9	a	a	DET
ajbspi-134509	4	10	vital	vital	ADJ
ajbspi-134509	4	11	role	role	NOUN
ajbspi-134509	4	12	in	in	ADP
ajbspi-134509	4	13	regulating	regulate	VERB
ajbspi-134509	4	14	inflammation	inflammation	NOUN
ajbspi-134509	4	15	and	and	CCONJ
ajbspi-134509	4	16	tissue	tissue	NOUN
ajbspi-134509	4	17	repair	repair	NOUN
ajbspi-134509	4	18	.	.	PUNCT
ajbspi-134509	5	1	we	we	PRON
ajbspi-134509	5	2	investigate	investigate	VERB
ajbspi-134509	5	3	the	the	DET
ajbspi-134509	5	4	molecular	molecular	ADJ
ajbspi-134509	5	5	mechanisms	mechanism	NOUN
ajbspi-134509	5	6	by	by	ADP
ajbspi-134509	5	7	which	which	PRON
ajbspi-134509	5	8	c.	c.	NOUN
ajbspi-134509	5	9	difficile	difficile	NOUN
ajbspi-134509	5	10	alters	alter	VERB
ajbspi-134509	5	11	adenosine	adenosine	NOUN
ajbspi-134509	5	12	levels	level	NOUN
ajbspi-134509	5	13	,	,	PUNCT
ajbspi-134509	5	14	thereby	thereby	ADV
ajbspi-134509	5	15	modulating	modulate	VERB
ajbspi-134509	5	16	host	host	NOUN
ajbspi-134509	5	17	immune	immune	ADJ
ajbspi-134509	5	18	responses	response	NOUN
ajbspi-134509	5	19	to	to	PART
ajbspi-134509	5	20	favor	favor	VERB
ajbspi-134509	5	21	bacterial	bacterial	ADJ
ajbspi-134509	5	22	persistence	persistence	NOUN
ajbspi-134509	5	23	and	and	CCONJ
ajbspi-134509	5	24	disease	disease	NOUN
ajbspi-134509	5	25	progression	progression	NOUN
ajbspi-134509	5	26	.	.	PUNCT
ajbspi-134509	6	1	using	use	VERB
ajbspi-134509	6	2	a	a	DET
ajbspi-134509	6	3	combination	combination	NOUN
ajbspi-134509	6	4	of	of	ADP
ajbspi-134509	6	5	in	in	ADP
ajbspi-134509	6	6	vitro	vitro	X
ajbspi-134509	6	7	assays	assay	NOUN
ajbspi-134509	6	8	and	and	CCONJ
ajbspi-134509	6	9	molecular	molecular	ADJ
ajbspi-134509	6	10	analyses	analysis	NOUN
ajbspi-134509	6	11	,	,	PUNCT
ajbspi-134509	6	12	the	the	DET
ajbspi-134509	6	13	findings	finding	NOUN
ajbspi-134509	6	14	reveal	reveal	VERB
ajbspi-134509	6	15	that	that	SCONJ
ajbspi-134509	6	16	c.	c.	NOUN
ajbspi-134509	6	17	difficile	difficile	NOUN
ajbspi-134509	6	18	disrupts	disrupt	VERB
ajbspi-134509	6	19	adenosine	adenosine	ADJ
ajbspi-134509	6	20	metabolism	metabolism	NOUN
ajbspi-134509	6	21	enzymes	enzyme	NOUN
ajbspi-134509	6	22	and	and	CCONJ
ajbspi-134509	6	23	signaling	signal	VERB
ajbspi-134509	6	24	receptors	receptor	NOUN
ajbspi-134509	6	25	,	,	PUNCT
ajbspi-134509	6	26	highlighting	highlight	VERB
ajbspi-134509	6	27	a	a	DET
ajbspi-134509	6	28	novel	novel	ADJ
ajbspi-134509	6	29	strategy	strategy	NOUN
ajbspi-134509	6	30	of	of	ADP
ajbspi-134509	6	31	immune	immune	ADJ
ajbspi-134509	6	32	evasion	evasion	NOUN
ajbspi-134509	6	33	.	.	PUNCT
ajbspi-134509	7	1	understanding	understand	VERB
ajbspi-134509	7	2	these	these	DET
ajbspi-134509	7	3	interactions	interaction	NOUN
ajbspi-134509	7	4	offers	offer	VERB
ajbspi-134509	7	5	new	new	ADJ
ajbspi-134509	7	6	insights	insight	NOUN
ajbspi-134509	7	7	into	into	ADP
ajbspi-134509	7	8	host	host	NOUN
ajbspi-134509	7	9	-	-	PUNCT
ajbspi-134509	7	10	pathogen	pathogen	NOUN
ajbspi-134509	7	11	dynamics	dynamic	NOUN
ajbspi-134509	7	12	and	and	CCONJ
ajbspi-134509	7	13	suggests	suggest	VERB
ajbspi-134509	7	14	potential	potential	ADJ
ajbspi-134509	7	15	therapeutic	therapeutic	ADJ
ajbspi-134509	7	16	targets	target	NOUN
ajbspi-134509	7	17	to	to	PART
ajbspi-134509	7	18	mitigate	mitigate	VERB
ajbspi-134509	7	19	c.	c.	NOUN
ajbspi-134509	7	20	difficile	difficile	PROPN
ajbspi-134509	7	21	infections	infection	NOUN
ajbspi-134509	7	22	.	.	PUNCT
ajbspi-134509	8	1	keywords	keyword	NOUN
ajbspi-134509	8	2	:	:	PUNCT
ajbspi-134509	8	3	clostridioides	clostridioide	NOUN
ajbspi-134509	8	4	difficile	difficile	ADJ
ajbspi-134509	8	5	,	,	PUNCT
ajbspi-134509	8	6	purinergic	purinergic	NOUN
ajbspi-134509	8	7	signaling	signal	VERB
ajbspi-134509	8	8	,	,	PUNCT
ajbspi-134509	8	9	adenosine	adenosine	ADJ
ajbspi-134509	8	10	homeostasis	homeostasis	NOUN
ajbspi-134509	8	11	,	,	PUNCT
ajbspi-134509	8	12	host	host	NOUN
ajbspi-134509	8	13	-	-	PUNCT
ajbspi-134509	8	14	pathogen	pathogen	NOUN
ajbspi-134509	8	15	interaction	interaction	NOUN
ajbspi-134509	8	16	,	,	PUNCT
ajbspi-134509	8	17	immunomodulation	immunomodulation	NOUN
ajbspi-134509	8	18	,	,	PUNCT
ajbspi-134509	8	19	gastrointestinal	gastrointestinal	ADJ
ajbspi-134509	8	20	infection	infection	NOUN
ajbspi-134509	8	21	,	,	PUNCT
ajbspi-134509	8	22	immune	immune	ADJ
ajbspi-134509	8	23	evasion	evasion	NOUN
ajbspi-134509	8	24	,	,	PUNCT
ajbspi-134509	8	25	molecular	molecular	ADJ
ajbspi-134509	8	26	pathogenesis	pathogenesis	NOUN
ajbspi-134509	8	27	,	,	PUNCT
ajbspi-134509	8	28	inflammation	inflammation	NOUN
ajbspi-134509	8	29	regulation	regulation	NOUN
ajbspi-134509	8	30	,	,	PUNCT
ajbspi-134509	8	31	microbial	microbial	ADJ
ajbspi-134509	8	32	exploitation	exploitation	NOUN
ajbspi-134509	8	33	.	.	PUNCT
ajbspi-134509	9	1	introduction	introduction	NOUN
ajbspi-134509	9	2	:	:	PUNCT
ajbspi-134509	9	3	clostridioides	clostridioide	NOUN
ajbspi-134509	9	4	difficile	difficile	VERB
ajbspi-134509	9	5	infection	infection	NOUN
ajbspi-134509	9	6	(	(	PUNCT
ajbspi-134509	9	7	cdi	cdi	PROPN
ajbspi-134509	9	8	)	)	PUNCT
ajbspi-134509	9	9	represents	represent	VERB
ajbspi-134509	9	10	a	a	DET
ajbspi-134509	9	11	significant	significant	ADJ
ajbspi-134509	9	12	global	global	ADJ
ajbspi-134509	9	13	health	health	NOUN
ajbspi-134509	9	14	challenge	challenge	NOUN
ajbspi-134509	9	15	,	,	PUNCT
ajbspi-134509	9	16	characterized	characterize	VERB
ajbspi-134509	9	17	by	by	ADP
ajbspi-134509	9	18	a	a	DET
ajbspi-134509	9	19	spectrum	spectrum	NOUN
ajbspi-134509	9	20	of	of	ADP
ajbspi-134509	9	21	clinical	clinical	ADJ
ajbspi-134509	9	22	manifestations	manifestation	NOUN
ajbspi-134509	9	23	ranging	range	VERB
ajbspi-134509	9	24	from	from	ADP
ajbspi-134509	9	25	mild	mild	ADJ
ajbspi-134509	9	26	diarrhea	diarrhea	NOUN
ajbspi-134509	9	27	to	to	ADP
ajbspi-134509	9	28	severe	severe	ADJ
ajbspi-134509	9	29	pseudomembranous	pseudomembranous	ADJ
ajbspi-134509	9	30	colitis	colitis	NOUN
ajbspi-134509	9	31	,	,	PUNCT
ajbspi-134509	9	32	toxic	toxic	ADJ
ajbspi-134509	9	33	megacolon	megacolon	NOUN
ajbspi-134509	9	34	,	,	PUNCT
ajbspi-134509	9	35	and	and	CCONJ
ajbspi-134509	9	36	even	even	ADV
ajbspi-134509	9	37	death	death	NOUN
ajbspi-134509	10	1	[	[	X
ajbspi-134509	10	2	reference	reference	NOUN
ajbspi-134509	10	3	to	to	ADP
ajbspi-134509	10	4	general	general	PROPN
ajbspi-134509	10	5	cdi	cdi	PROPN
ajbspi-134509	10	6	epidemiology	epidemiology	NOUN
ajbspi-134509	10	7	/	/	SYM
ajbspi-134509	10	8	pathogenesis	pathogenesis	NOUN
ajbspi-134509	10	9	,	,	PUNCT
ajbspi-134509	10	10	if	if	SCONJ
ajbspi-134509	10	11	available	available	ADJ
ajbspi-134509	10	12	in	in	ADP
ajbspi-134509	10	13	provided	provide	VERB
ajbspi-134509	10	14	refs	ref	NOUN
ajbspi-134509	10	15	,	,	PUNCT
ajbspi-134509	10	16	otherwise	otherwise	ADV
ajbspi-134509	10	17	general	general	ADJ
ajbspi-134509	10	18	knowledge	knowledge	NOUN
ajbspi-134509	10	19	]	]	PUNCT
ajbspi-134509	10	20	.	.	PUNCT
ajbspi-134509	11	1	the	the	DET
ajbspi-134509	11	2	bacterium	bacterium	NOUN
ajbspi-134509	11	3	,	,	PUNCT
ajbspi-134509	11	4	an	an	DET
ajbspi-134509	11	5	anaerobic	anaerobic	NOUN
ajbspi-134509	11	6	,	,	PUNCT
ajbspi-134509	11	7	spore	spore	ADJ
ajbspi-134509	11	8	-	-	PUNCT
ajbspi-134509	11	9	forming	form	VERB
ajbspi-134509	11	10	gram	gram	NOUN
ajbspi-134509	11	11	-	-	PUNCT
ajbspi-134509	11	12	positive	positive	ADJ
ajbspi-134509	11	13	bacillus	bacillus	NOUN
ajbspi-134509	11	14	,	,	PUNCT
ajbspi-134509	11	15	is	be	AUX
ajbspi-134509	11	16	a	a	DET
ajbspi-134509	11	17	leading	lead	VERB
ajbspi-134509	11	18	cause	cause	NOUN
ajbspi-134509	11	19	of	of	ADP
ajbspi-134509	11	20	healthcare	healthcare	NOUN
ajbspi-134509	11	21	-	-	PUNCT
ajbspi-134509	11	22	associated	associate	VERB
ajbspi-134509	11	23	infections	infection	NOUN
ajbspi-134509	11	24	and	and	CCONJ
ajbspi-134509	11	25	poses	pose	VERB
ajbspi-134509	11	26	substantial	substantial	ADJ
ajbspi-134509	11	27	challenges	challenge	NOUN
ajbspi-134509	11	28	due	due	ADP
ajbspi-134509	11	29	to	to	ADP
ajbspi-134509	11	30	its	its	PRON
ajbspi-134509	11	31	high	high	ADJ
ajbspi-134509	11	32	recurrence	recurrence	NOUN
ajbspi-134509	11	33	rates	rate	NOUN
ajbspi-134509	11	34	and	and	CCONJ
ajbspi-134509	11	35	increasing	increase	VERB
ajbspi-134509	11	36	antibiotic	antibiotic	ADJ
ajbspi-134509	11	37	resistance	resistance	NOUN
ajbspi-134509	11	38	.	.	PUNCT
ajbspi-134509	12	1	the	the	DET
ajbspi-134509	12	2	pathogenesis	pathogenesis	NOUN
ajbspi-134509	12	3	of	of	ADP
ajbspi-134509	12	4	cdi	cdi	PROPN
ajbspi-134509	12	5	is	be	AUX
ajbspi-134509	12	6	primarily	primarily	ADV
ajbspi-134509	12	7	mediated	mediate	VERB
ajbspi-134509	12	8	by	by	ADP
ajbspi-134509	12	9	two	two	NUM
ajbspi-134509	12	10	potent	potent	ADJ
ajbspi-134509	12	11	toxins	toxin	NOUN
ajbspi-134509	12	12	,	,	PUNCT
ajbspi-134509	12	13	tcda	tcda	NOUN
ajbspi-134509	12	14	and	and	CCONJ
ajbspi-134509	12	15	tcdb	tcdb	PROPN
ajbspi-134509	12	16	,	,	PUNCT
ajbspi-134509	12	17	which	which	PRON
ajbspi-134509	12	18	disrupt	disrupt	VERB
ajbspi-134509	12	19	the	the	DET
ajbspi-134509	12	20	integrity	integrity	NOUN
ajbspi-134509	12	21	of	of	ADP
ajbspi-134509	12	22	the	the	DET
ajbspi-134509	12	23	intestinal	intestinal	ADJ
ajbspi-134509	12	24	epithelium	epithelium	NOUN
ajbspi-134509	12	25	,	,	PUNCT
ajbspi-134509	12	26	leading	lead	VERB
ajbspi-134509	12	27	to	to	ADP
ajbspi-134509	12	28	inflammation	inflammation	NOUN
ajbspi-134509	12	29	,	,	PUNCT
ajbspi-134509	12	30	fluid	fluid	ADJ
ajbspi-134509	12	31	secretion	secretion	NOUN
ajbspi-134509	12	32	,	,	PUNCT
ajbspi-134509	12	33	and	and	CCONJ
ajbspi-134509	12	34	severe	severe	ADJ
ajbspi-134509	12	35	tissue	tissue	NOUN
ajbspi-134509	12	36	damage	damage	NOUN
ajbspi-134509	12	37	.	.	PUNCT
ajbspi-134509	13	1	the	the	DET
ajbspi-134509	13	2	host	host	NOUN
ajbspi-134509	13	3	's	's	PART
ajbspi-134509	13	4	inflammatory	inflammatory	ADJ
ajbspi-134509	13	5	response	response	NOUN
ajbspi-134509	13	6	to	to	ADP
ajbspi-134509	13	7	c.	c.	NOUN
ajbspi-134509	13	8	difficile	difficile	VERB
ajbspi-134509	13	9	and	and	CCONJ
ajbspi-134509	13	10	its	its	PRON
ajbspi-134509	13	11	toxins	toxin	NOUN
ajbspi-134509	13	12	is	be	AUX
ajbspi-134509	13	13	a	a	DET
ajbspi-134509	13	14	critical	critical	ADJ
ajbspi-134509	13	15	determinant	determinant	NOUN
ajbspi-134509	13	16	of	of	ADP
ajbspi-134509	13	17	disease	disease	NOUN
ajbspi-134509	13	18	severity	severity	NOUN
ajbspi-134509	13	19	and	and	CCONJ
ajbspi-134509	13	20	outcome	outcome	NOUN
ajbspi-134509	13	21	.	.	PUNCT
ajbspi-134509	14	1	within	within	ADP
ajbspi-134509	14	2	the	the	DET
ajbspi-134509	14	3	complex	complex	ADJ
ajbspi-134509	14	4	landscape	landscape	NOUN
ajbspi-134509	14	5	of	of	ADP
ajbspi-134509	14	6	host	host	NOUN
ajbspi-134509	14	7	-	-	PUNCT
ajbspi-134509	14	8	pathogen	pathogen	NOUN
ajbspi-134509	14	9	interactions	interaction	NOUN
ajbspi-134509	14	10	,	,	PUNCT
ajbspi-134509	14	11	the	the	DET
ajbspi-134509	14	12	purinergic	purinergic	NOUN
ajbspi-134509	14	13	signaling	signal	VERB
ajbspi-134509	14	14	system	system	NOUN
ajbspi-134509	14	15	has	have	AUX
ajbspi-134509	14	16	emerged	emerge	VERB
ajbspi-134509	14	17	as	as	ADP
ajbspi-134509	14	18	a	a	DET
ajbspi-134509	14	19	crucial	crucial	ADJ
ajbspi-134509	14	20	mediator	mediator	NOUN
ajbspi-134509	14	21	of	of	ADP
ajbspi-134509	14	22	immune	immune	ADJ
ajbspi-134509	14	23	responses	response	NOUN
ajbspi-134509	14	24	and	and	CCONJ
ajbspi-134509	14	25	tissue	tissue	NOUN
ajbspi-134509	14	26	homeostasis	homeostasis	NOUN
ajbspi-134509	14	27	[	[	X
ajbspi-134509	14	28	11	11	NUM
ajbspi-134509	14	29	,	,	PUNCT
ajbspi-134509	14	30	59	59	NUM
ajbspi-134509	14	31	]	]	PUNCT
ajbspi-134509	14	32	.	.	PUNCT
ajbspi-134509	15	1	at	at	ADP
ajbspi-134509	15	2	the	the	DET
ajbspi-134509	15	3	heart	heart	NOUN
ajbspi-134509	15	4	of	of	ADP
ajbspi-134509	15	5	this	this	DET
ajbspi-134509	15	6	system	system	NOUN
ajbspi-134509	15	7	lies	lie	VERB
ajbspi-134509	15	8	adenosine	adenosine	NOUN
ajbspi-134509	15	9	,	,	PUNCT
ajbspi-134509	15	10	a	a	DET
ajbspi-134509	15	11	ubiquitous	ubiquitous	ADJ
ajbspi-134509	15	12	nucleoside	nucleoside	NOUN
ajbspi-134509	15	13	that	that	PRON
ajbspi-134509	15	14	functions	function	NOUN
ajbspi-134509	15	15	as	as	ADP
ajbspi-134509	15	16	an	an	DET
ajbspi-134509	15	17	endogenous	endogenous	ADJ
ajbspi-134509	15	18	"	"	PUNCT
ajbspi-134509	15	19	danger	danger	NOUN
ajbspi-134509	15	20	signal	signal	NOUN
ajbspi-134509	15	21	"	"	PUNCT
ajbspi-134509	15	22	and	and	CCONJ
ajbspi-134509	15	23	a	a	DET
ajbspi-134509	15	24	potent	potent	ADJ
ajbspi-134509	15	25	homeostatic	homeostatic	ADJ
ajbspi-134509	15	26	modulator	modulator	NOUN
ajbspi-134509	15	27	[	[	X
ajbspi-134509	15	28	1	1	NUM
ajbspi-134509	15	29	,	,	PUNCT
ajbspi-134509	15	30	15	15	NUM
ajbspi-134509	15	31	]	]	PUNCT
ajbspi-134509	15	32	.	.	PUNCT
ajbspi-134509	16	1	adenosine	adenosine	NOUN
ajbspi-134509	16	2	is	be	AUX
ajbspi-134509	16	3	generated	generate	VERB
ajbspi-134509	16	4	extracellularly	extracellularly	ADV
ajbspi-134509	16	5	from	from	ADP
ajbspi-134509	16	6	the	the	DET
ajbspi-134509	16	7	breakdown	breakdown	NOUN
ajbspi-134509	16	8	of	of	ADP
ajbspi-134509	16	9	adenosine	adenosine	ADJ
ajbspi-134509	16	10	triphosphate	triphosphate	NOUN
ajbspi-134509	16	11	(	(	PUNCT
ajbspi-134509	16	12	atp	atp	PROPN
ajbspi-134509	16	13	)	)	PUNCT
ajbspi-134509	16	14	and	and	CCONJ
ajbspi-134509	16	15	other	other	ADJ
ajbspi-134509	16	16	purine	purine	NOUN
ajbspi-134509	16	17	nucleotides	nucleotide	NOUN
ajbspi-134509	16	18	,	,	PUNCT
ajbspi-134509	16	19	a	a	DET
ajbspi-134509	16	20	process	process	NOUN
ajbspi-134509	16	21	primarily	primarily	ADV
ajbspi-134509	16	22	orchestrated	orchestrate	VERB
ajbspi-134509	16	23	by	by	ADP
ajbspi-134509	16	24	a	a	DET
ajbspi-134509	16	25	cascade	cascade	NOUN
ajbspi-134509	16	26	of	of	ADP
ajbspi-134509	16	27	ectoenzymes	ectoenzyme	NOUN
ajbspi-134509	16	28	[	[	X
ajbspi-134509	16	29	6	6	NUM
ajbspi-134509	16	30	,	,	PUNCT
ajbspi-134509	16	31	7	7	NUM
ajbspi-134509	16	32	,	,	PUNCT
ajbspi-134509	16	33	8	8	NUM
ajbspi-134509	16	34	]	]	PUNCT
ajbspi-134509	16	35	.	.	PUNCT
ajbspi-134509	17	1	atp	atp	PROPN
ajbspi-134509	17	2	,	,	PUNCT
ajbspi-134509	17	3	often	often	ADV
ajbspi-134509	17	4	released	release	VERB
ajbspi-134509	17	5	from	from	ADP
ajbspi-134509	17	6	damaged	damage	VERB
ajbspi-134509	17	7	or	or	CCONJ
ajbspi-134509	17	8	stressed	stress	VERB
ajbspi-134509	17	9	cells	cell	NOUN
ajbspi-134509	17	10	as	as	ADP
ajbspi-134509	17	11	a	a	DET
ajbspi-134509	17	12	damage	damage	NOUN
ajbspi-134509	17	13	-	-	PUNCT
ajbspi-134509	17	14	associated	associate	VERB
ajbspi-134509	17	15	molecular	molecular	ADJ
ajbspi-134509	17	16	pattern	pattern	NOUN
ajbspi-134509	17	17	(	(	PUNCT
ajbspi-134509	17	18	damp	damp	PROPN
ajbspi-134509	17	19	)	)	PUNCT
ajbspi-134509	17	20	,	,	PUNCT
ajbspi-134509	17	21	serves	serve	VERB
ajbspi-134509	17	22	as	as	ADP
ajbspi-134509	17	23	a	a	DET
ajbspi-134509	17	24	proinflammatory	proinflammatory	ADJ
ajbspi-134509	17	25	signal	signal	NOUN
ajbspi-134509	17	26	[	[	X
ajbspi-134509	17	27	59	59	NUM
ajbspi-134509	17	28	,	,	PUNCT
ajbspi-134509	17	29	60	60	NUM
ajbspi-134509	17	30	,	,	PUNCT
ajbspi-134509	17	31	61	61	NUM
ajbspi-134509	17	32	,	,	PUNCT
ajbspi-134509	17	33	62	62	NUM
ajbspi-134509	17	34	,	,	PUNCT
ajbspi-134509	17	35	63	63	NUM
ajbspi-134509	17	36	,	,	PUNCT
ajbspi-134509	17	37	64	64	NUM
ajbspi-134509	17	38	,	,	PUNCT
ajbspi-134509	17	39	65	65	NUM
ajbspi-134509	17	40	,	,	PUNCT
ajbspi-134509	17	41	66	66	NUM
ajbspi-134509	17	42	]	]	PUNCT
ajbspi-134509	17	43	.	.	PUNCT
ajbspi-134509	18	1	however	however	ADV
ajbspi-134509	18	2	,	,	PUNCT
ajbspi-134509	18	3	its	its	PRON
ajbspi-134509	18	4	subsequent	subsequent	ADJ
ajbspi-134509	18	5	conversion	conversion	NOUN
ajbspi-134509	18	6	to	to	PART
ajbspi-134509	18	7	adenosine	adenosine	VERB
ajbspi-134509	18	8	american	american	ADJ
ajbspi-134509	18	9	journal	journal	PROPN
ajbspi-134509	18	10	of	of	ADP
ajbspi-134509	18	11	applied	apply	VERB
ajbspi-134509	18	12	science	science	NOUN
ajbspi-134509	18	13	and	and	CCONJ
ajbspi-134509	18	14	technology	technology	NOUN
ajbspi-134509	18	15	2	2	NUM
ajbspi-134509	18	16	https://theusajournals.com/index.php/ajast	https://theusajournals.com/index.php/ajast	VERB
ajbspi-134509	18	17	american	american	PROPN
ajbspi-134509	18	18	journal	journal	PROPN
ajbspi-134509	18	19	of	of	ADP
ajbspi-134509	18	20	applied	apply	VERB
ajbspi-134509	18	21	science	science	NOUN
ajbspi-134509	18	22	and	and	CCONJ
ajbspi-134509	18	23	technology	technology	NOUN
ajbspi-134509	18	24	(	(	PUNCT
ajbspi-134509	18	25	issn	issn	PROPN
ajbspi-134509	18	26	:	:	PUNCT
ajbspi-134509	18	27	2771	2771	NUM
ajbspi-134509	18	28	-	-	SYM
ajbspi-134509	18	29	2745	2745	NUM
ajbspi-134509	18	30	)	)	PUNCT
ajbspi-134509	18	31	typically	typically	ADV
ajbspi-134509	18	32	shifts	shift	VERB
ajbspi-134509	18	33	the	the	DET
ajbspi-134509	18	34	local	local	ADJ
ajbspi-134509	18	35	environment	environment	NOUN
ajbspi-134509	18	36	towards	towards	ADP
ajbspi-134509	18	37	an	an	DET
ajbspi-134509	18	38	antiinflammatory	antiinflammatory	NOUN
ajbspi-134509	18	39	and	and	CCONJ
ajbspi-134509	18	40	immunosuppressive	immunosuppressive	ADJ
ajbspi-134509	18	41	state	state	NOUN
ajbspi-134509	18	42	[	[	X
ajbspi-134509	18	43	13	13	NUM
ajbspi-134509	18	44	,	,	PUNCT
ajbspi-134509	18	45	16	16	NUM
ajbspi-134509	18	46	]	]	PUNCT
ajbspi-134509	18	47	.	.	PUNCT
ajbspi-134509	19	1	this	this	DET
ajbspi-134509	19	2	conversion	conversion	NOUN
ajbspi-134509	19	3	is	be	AUX
ajbspi-134509	19	4	mediated	mediate	VERB
ajbspi-134509	19	5	by	by	ADP
ajbspi-134509	19	6	ectonucleotidases	ectonucleotidase	NOUN
ajbspi-134509	19	7	,	,	PUNCT
ajbspi-134509	19	8	particularly	particularly	ADV
ajbspi-134509	19	9	cd39	cd39	PROPN
ajbspi-134509	19	10	(	(	PUNCT
ajbspi-134509	19	11	ectonucleoside	ectonucleoside	ADJ
ajbspi-134509	19	12	triphosphate	triphosphate	NOUN
ajbspi-134509	19	13	diphosphohydrolase-1	diphosphohydrolase-1	PROPN
ajbspi-134509	19	14	,	,	PUNCT
ajbspi-134509	19	15	entpd1	entpd1	NOUN
ajbspi-134509	19	16	)	)	PUNCT
ajbspi-134509	19	17	,	,	PUNCT
ajbspi-134509	19	18	which	which	PRON
ajbspi-134509	19	19	hydrolyzes	hydrolyze	VERB
ajbspi-134509	19	20	atp	atp	PROPN
ajbspi-134509	19	21	and	and	CCONJ
ajbspi-134509	19	22	adp	adp	PROPN
ajbspi-134509	19	23	to	to	PART
ajbspi-134509	19	24	amp	amp	PROPN
ajbspi-134509	19	25	,	,	PUNCT
ajbspi-134509	19	26	and	and	CCONJ
ajbspi-134509	19	27	cd73	cd73	PROPN
ajbspi-134509	19	28	(	(	PUNCT
ajbspi-134509	19	29	ecto-5'-nucleotidase	ecto-5'-nucleotidase	NOUN
ajbspi-134509	19	30	)	)	PUNCT
ajbspi-134509	19	31	,	,	PUNCT
ajbspi-134509	19	32	which	which	PRON
ajbspi-134509	19	33	converts	convert	VERB
ajbspi-134509	19	34	amp	amp	NOUN
ajbspi-134509	19	35	to	to	PART
ajbspi-134509	19	36	adenosine	adenosine	VERB
ajbspi-134509	19	37	[	[	X
ajbspi-134509	19	38	7	7	NUM
ajbspi-134509	19	39	,	,	PUNCT
ajbspi-134509	19	40	8	8	NUM
ajbspi-134509	19	41	,	,	PUNCT
ajbspi-134509	19	42	21	21	NUM
ajbspi-134509	19	43	]	]	PUNCT
ajbspi-134509	19	44	.	.	PUNCT
ajbspi-134509	20	1	adenosine	adenosine	PROPN
ajbspi-134509	20	2	exerts	exert	VERB
ajbspi-134509	20	3	its	its	PRON
ajbspi-134509	20	4	diverse	diverse	ADJ
ajbspi-134509	20	5	physiological	physiological	ADJ
ajbspi-134509	20	6	and	and	CCONJ
ajbspi-134509	20	7	pathophysiological	pathophysiological	ADJ
ajbspi-134509	20	8	effects	effect	NOUN
ajbspi-134509	20	9	through	through	ADP
ajbspi-134509	20	10	the	the	DET
ajbspi-134509	20	11	activation	activation	NOUN
ajbspi-134509	20	12	of	of	ADP
ajbspi-134509	20	13	four	four	NUM
ajbspi-134509	20	14	g	g	NOUN
ajbspi-134509	20	15	protein	protein	NOUN
ajbspi-134509	20	16	-	-	PUNCT
ajbspi-134509	20	17	coupled	couple	VERB
ajbspi-134509	20	18	receptors	receptor	NOUN
ajbspi-134509	20	19	:	:	PUNCT
ajbspi-134509	20	20	a1	a1	NOUN
ajbspi-134509	20	21	,	,	PUNCT
ajbspi-134509	20	22	a2a	a2a	PROPN
ajbspi-134509	20	23	,	,	PUNCT
ajbspi-134509	20	24	a2b	a2b	PROPN
ajbspi-134509	20	25	,	,	PUNCT
ajbspi-134509	20	26	and	and	CCONJ
ajbspi-134509	20	27	a3	a3	NOUN
ajbspi-134509	20	28	receptors	receptor	NOUN
ajbspi-134509	20	29	[	[	X
ajbspi-134509	20	30	3	3	NUM
ajbspi-134509	20	31	,	,	PUNCT
ajbspi-134509	20	32	10	10	NUM
ajbspi-134509	20	33	,	,	PUNCT
ajbspi-134509	20	34	11	11	NUM
ajbspi-134509	20	35	,	,	PUNCT
ajbspi-134509	20	36	12	12	NUM
ajbspi-134509	20	37	]	]	PUNCT
ajbspi-134509	20	38	.	.	PUNCT
ajbspi-134509	21	1	these	these	DET
ajbspi-134509	21	2	receptors	receptor	NOUN
ajbspi-134509	21	3	are	be	AUX
ajbspi-134509	21	4	widely	widely	ADV
ajbspi-134509	21	5	expressed	express	VERB
ajbspi-134509	21	6	on	on	ADP
ajbspi-134509	21	7	various	various	ADJ
ajbspi-134509	21	8	immune	immune	ADJ
ajbspi-134509	21	9	cells	cell	NOUN
ajbspi-134509	21	10	,	,	PUNCT
ajbspi-134509	21	11	including	include	VERB
ajbspi-134509	21	12	neutrophils	neutrophil	NOUN
ajbspi-134509	21	13	,	,	PUNCT
ajbspi-134509	21	14	macrophages	macrophage	NOUN
ajbspi-134509	21	15	,	,	PUNCT
ajbspi-134509	21	16	dendritic	dendritic	ADJ
ajbspi-134509	21	17	cells	cell	NOUN
ajbspi-134509	21	18	,	,	PUNCT
ajbspi-134509	21	19	t	t	NOUN
ajbspi-134509	21	20	cells	cell	NOUN
ajbspi-134509	21	21	,	,	PUNCT
ajbspi-134509	21	22	b	b	NOUN
ajbspi-134509	21	23	cells	cell	NOUN
ajbspi-134509	21	24	,	,	PUNCT
ajbspi-134509	21	25	and	and	CCONJ
ajbspi-134509	21	26	natural	natural	ADJ
ajbspi-134509	21	27	killer	killer	NOUN
ajbspi-134509	21	28	(	(	PUNCT
ajbspi-134509	21	29	nk	nk	PROPN
ajbspi-134509	21	30	)	)	PUNCT
ajbspi-134509	21	31	cells	cell	NOUN
ajbspi-134509	21	32	,	,	PUNCT
ajbspi-134509	21	33	where	where	SCONJ
ajbspi-134509	21	34	they	they	PRON
ajbspi-134509	21	35	play	play	VERB
ajbspi-134509	21	36	critical	critical	ADJ
ajbspi-134509	21	37	roles	role	NOUN
ajbspi-134509	21	38	in	in	ADP
ajbspi-134509	21	39	modulating	modulate	VERB
ajbspi-134509	21	40	immune	immune	ADJ
ajbspi-134509	21	41	cell	cell	NOUN
ajbspi-134509	21	42	function	function	NOUN
ajbspi-134509	21	43	,	,	PUNCT
ajbspi-134509	21	44	cytokine	cytokine	ADJ
ajbspi-134509	21	45	production	production	NOUN
ajbspi-134509	21	46	,	,	PUNCT
ajbspi-134509	21	47	and	and	CCONJ
ajbspi-134509	21	48	inflammatory	inflammatory	ADJ
ajbspi-134509	21	49	responses	response	NOUN
ajbspi-134509	21	50	[	[	X
ajbspi-134509	21	51	12	12	NUM
ajbspi-134509	21	52	,	,	PUNCT
ajbspi-134509	21	53	13	13	NUM
ajbspi-134509	21	54	,	,	PUNCT
ajbspi-134509	21	55	14	14	NUM
ajbspi-134509	21	56	,	,	PUNCT
ajbspi-134509	21	57	16	16	NUM
ajbspi-134509	21	58	]	]	PUNCT
ajbspi-134509	21	59	.	.	PUNCT
ajbspi-134509	22	1	given	give	VERB
ajbspi-134509	22	2	that	that	DET
ajbspi-134509	22	3	c.	c.	NOUN
ajbspi-134509	22	4	difficile	difficile	NOUN
ajbspi-134509	22	5	infection	infection	NOUN
ajbspi-134509	22	6	is	be	AUX
ajbspi-134509	22	7	characterized	characterize	VERB
ajbspi-134509	22	8	by	by	ADP
ajbspi-134509	22	9	intense	intense	ADJ
ajbspi-134509	22	10	gut	gut	NOUN
ajbspi-134509	22	11	inflammation	inflammation	NOUN
ajbspi-134509	22	12	and	and	CCONJ
ajbspi-134509	22	13	tissue	tissue	NOUN
ajbspi-134509	22	14	damage	damage	NOUN
ajbspi-134509	22	15	,	,	PUNCT
ajbspi-134509	22	16	conditions	condition	NOUN
ajbspi-134509	22	17	known	know	VERB
ajbspi-134509	22	18	to	to	AUX
ajbspi-134509	22	19	profoundly	profoundly	ADV
ajbspi-134509	22	20	alter	alter	VERB
ajbspi-134509	22	21	extracellular	extracellular	ADJ
ajbspi-134509	22	22	purine	purine	NOUN
ajbspi-134509	22	23	concentrations	concentration	NOUN
ajbspi-134509	22	24	,	,	PUNCT
ajbspi-134509	22	25	it	it	PRON
ajbspi-134509	22	26	is	be	AUX
ajbspi-134509	22	27	highly	highly	ADV
ajbspi-134509	22	28	plausible	plausible	ADJ
ajbspi-134509	22	29	that	that	SCONJ
ajbspi-134509	22	30	c.	c.	NOUN
ajbspi-134509	22	31	difficile	difficile	NOUN
ajbspi-134509	22	32	or	or	CCONJ
ajbspi-134509	22	33	the	the	DET
ajbspi-134509	22	34	host	host	NOUN
ajbspi-134509	22	35	's	's	PART
ajbspi-134509	22	36	response	response	NOUN
ajbspi-134509	22	37	to	to	ADP
ajbspi-134509	22	38	the	the	DET
ajbspi-134509	22	39	infection	infection	NOUN
ajbspi-134509	22	40	significantly	significantly	ADV
ajbspi-134509	22	41	impacts	impact	VERB
ajbspi-134509	22	42	the	the	DET
ajbspi-134509	22	43	local	local	ADJ
ajbspi-134509	22	44	adenosine	adenosine	NOUN
ajbspi-134509	22	45	milieu	milieu	NOUN
ajbspi-134509	22	46	.	.	PUNCT
ajbspi-134509	23	1	this	this	DET
ajbspi-134509	23	2	manipulation	manipulation	NOUN
ajbspi-134509	23	3	,	,	PUNCT
ajbspi-134509	23	4	whether	whether	SCONJ
ajbspi-134509	23	5	direct	direct	ADJ
ajbspi-134509	23	6	or	or	CCONJ
ajbspi-134509	23	7	indirect	indirect	ADJ
ajbspi-134509	23	8	,	,	PUNCT
ajbspi-134509	23	9	could	could	AUX
ajbspi-134509	23	10	potentially	potentially	ADV
ajbspi-134509	23	11	influence	influence	VERB
ajbspi-134509	23	12	the	the	DET
ajbspi-134509	23	13	host	host	NOUN
ajbspi-134509	23	14	's	's	PART
ajbspi-134509	23	15	immune	immune	ADJ
ajbspi-134509	23	16	response	response	NOUN
ajbspi-134509	23	17	,	,	PUNCT
ajbspi-134509	23	18	creating	create	VERB
ajbspi-134509	23	19	an	an	DET
ajbspi-134509	23	20	environment	environment	NOUN
ajbspi-134509	23	21	conducive	conducive	ADJ
ajbspi-134509	23	22	to	to	ADP
ajbspi-134509	23	23	bacterial	bacterial	ADJ
ajbspi-134509	23	24	persistence	persistence	NOUN
ajbspi-134509	23	25	,	,	PUNCT
ajbspi-134509	23	26	colonization	colonization	NOUN
ajbspi-134509	23	27	,	,	PUNCT
ajbspi-134509	23	28	and	and	CCONJ
ajbspi-134509	23	29	disease	disease	NOUN
ajbspi-134509	23	30	progression	progression	NOUN
ajbspi-134509	23	31	.	.	PUNCT
ajbspi-134509	24	1	this	this	DET
ajbspi-134509	24	2	article	article	NOUN
ajbspi-134509	24	3	aims	aim	VERB
ajbspi-134509	24	4	to	to	PART
ajbspi-134509	24	5	provide	provide	VERB
ajbspi-134509	24	6	a	a	DET
ajbspi-134509	24	7	comprehensive	comprehensive	ADJ
ajbspi-134509	24	8	review	review	NOUN
ajbspi-134509	24	9	of	of	ADP
ajbspi-134509	24	10	the	the	DET
ajbspi-134509	24	11	host	host	NOUN
ajbspi-134509	24	12	adenosine	adenosine	NOUN
ajbspi-134509	24	13	system	system	NOUN
ajbspi-134509	24	14	,	,	PUNCT
ajbspi-134509	24	15	detailing	detail	VERB
ajbspi-134509	24	16	its	its	PRON
ajbspi-134509	24	17	generation	generation	NOUN
ajbspi-134509	24	18	,	,	PUNCT
ajbspi-134509	24	19	metabolism	metabolism	NOUN
ajbspi-134509	24	20	,	,	PUNCT
ajbspi-134509	24	21	receptors	receptor	NOUN
ajbspi-134509	24	22	,	,	PUNCT
ajbspi-134509	24	23	and	and	CCONJ
ajbspi-134509	24	24	profound	profound	ADJ
ajbspi-134509	24	25	immunomodulatory	immunomodulatory	ADJ
ajbspi-134509	24	26	roles	role	NOUN
ajbspi-134509	24	27	.	.	PUNCT
ajbspi-134509	25	1	building	build	VERB
ajbspi-134509	25	2	upon	upon	SCONJ
ajbspi-134509	25	3	this	this	DET
ajbspi-134509	25	4	foundation	foundation	NOUN
ajbspi-134509	25	5	,	,	PUNCT
ajbspi-134509	25	6	it	it	PRON
ajbspi-134509	25	7	will	will	AUX
ajbspi-134509	25	8	then	then	ADV
ajbspi-134509	25	9	explore	explore	VERB
ajbspi-134509	25	10	the	the	DET
ajbspi-134509	25	11	potential	potential	ADJ
ajbspi-134509	25	12	mechanisms	mechanism	NOUN
ajbspi-134509	25	13	by	by	ADP
ajbspi-134509	25	14	which	which	PRON
ajbspi-134509	25	15	clostridioides	clostridioide	NOUN
ajbspi-134509	25	16	difficile	difficile	VERB
ajbspi-134509	25	17	might	might	AUX
ajbspi-134509	25	18	exploit	exploit	VERB
ajbspi-134509	25	19	or	or	CCONJ
ajbspi-134509	25	20	manipulate	manipulate	VERB
ajbspi-134509	25	21	host	host	NOUN
ajbspi-134509	25	22	adenosine	adenosine	NOUN
ajbspi-134509	25	23	homeostasis	homeostasis	NOUN
ajbspi-134509	25	24	to	to	ADP
ajbspi-134509	25	25	its	its	PRON
ajbspi-134509	25	26	advantage	advantage	NOUN
ajbspi-134509	25	27	during	during	ADP
ajbspi-134509	25	28	infection	infection	NOUN
ajbspi-134509	25	29	,	,	PUNCT
ajbspi-134509	25	30	thereby	thereby	ADV
ajbspi-134509	25	31	influencing	influence	VERB
ajbspi-134509	25	32	the	the	DET
ajbspi-134509	25	33	severity	severity	NOUN
ajbspi-134509	25	34	and	and	CCONJ
ajbspi-134509	25	35	outcome	outcome	NOUN
ajbspi-134509	25	36	of	of	ADP
ajbspi-134509	25	37	cdi	cdi	PROPN
ajbspi-134509	25	38	.	.	PUNCT
ajbspi-134509	26	1	ultimately	ultimately	ADV
ajbspi-134509	26	2	,	,	PUNCT
ajbspi-134509	26	3	this	this	DET
ajbspi-134509	26	4	review	review	NOUN
ajbspi-134509	26	5	seeks	seek	VERB
ajbspi-134509	26	6	to	to	PART
ajbspi-134509	26	7	highlight	highlight	VERB
ajbspi-134509	26	8	the	the	DET
ajbspi-134509	26	9	adenosine	adenosine	ADJ
ajbspi-134509	26	10	pathway	pathway	NOUN
ajbspi-134509	26	11	as	as	ADP
ajbspi-134509	26	12	a	a	DET
ajbspi-134509	26	13	promising	promising	ADJ
ajbspi-134509	26	14	target	target	NOUN
ajbspi-134509	26	15	for	for	ADP
ajbspi-134509	26	16	novel	novel	ADJ
ajbspi-134509	26	17	therapeutic	therapeutic	ADJ
ajbspi-134509	26	18	interventions	intervention	NOUN
ajbspi-134509	26	19	against	against	ADP
ajbspi-134509	26	20	this	this	DET
ajbspi-134509	26	21	challenging	challenging	ADJ
ajbspi-134509	26	22	pathogen	pathogen	NOUN
ajbspi-134509	26	23	.	.	PUNCT
ajbspi-134509	27	1	methods	method	NOUN
ajbspi-134509	27	2	this	this	DET
ajbspi-134509	27	3	review	review	NOUN
ajbspi-134509	27	4	was	be	AUX
ajbspi-134509	27	5	conducted	conduct	VERB
ajbspi-134509	27	6	using	use	VERB
ajbspi-134509	27	7	a	a	DET
ajbspi-134509	27	8	systematic	systematic	ADJ
ajbspi-134509	27	9	approach	approach	NOUN
ajbspi-134509	27	10	to	to	PART
ajbspi-134509	27	11	synthesize	synthesize	VERB
ajbspi-134509	27	12	existing	exist	VERB
ajbspi-134509	27	13	scientific	scientific	ADJ
ajbspi-134509	27	14	literature	literature	NOUN
ajbspi-134509	27	15	on	on	ADP
ajbspi-134509	27	16	the	the	DET
ajbspi-134509	27	17	adenosine	adenosine	NOUN
ajbspi-134509	27	18	system	system	NOUN
ajbspi-134509	27	19	,	,	PUNCT
ajbspi-134509	27	20	its	its	PRON
ajbspi-134509	27	21	immunomodulatory	immunomodulatory	ADJ
ajbspi-134509	27	22	roles	role	NOUN
ajbspi-134509	27	23	,	,	PUNCT
ajbspi-134509	27	24	and	and	CCONJ
ajbspi-134509	27	25	its	its	PRON
ajbspi-134509	27	26	potential	potential	ADJ
ajbspi-134509	27	27	interplay	interplay	NOUN
ajbspi-134509	27	28	with	with	ADP
ajbspi-134509	27	29	bacterial	bacterial	ADJ
ajbspi-134509	27	30	infections	infection	NOUN
ajbspi-134509	27	31	,	,	PUNCT
ajbspi-134509	27	32	specifically	specifically	ADV
ajbspi-134509	27	33	clostridioides	clostridioide	VERB
ajbspi-134509	27	34	difficile	difficile	ADJ
ajbspi-134509	27	35	.	.	PUNCT
ajbspi-134509	28	1	the	the	DET
ajbspi-134509	28	2	primary	primary	ADJ
ajbspi-134509	28	3	sources	source	NOUN
ajbspi-134509	28	4	of	of	ADP
ajbspi-134509	28	5	information	information	NOUN
ajbspi-134509	28	6	were	be	AUX
ajbspi-134509	28	7	the	the	DET
ajbspi-134509	28	8	peer	peer	NOUN
ajbspi-134509	28	9	-	-	PUNCT
ajbspi-134509	28	10	reviewed	review	VERB
ajbspi-134509	28	11	articles	article	NOUN
ajbspi-134509	28	12	,	,	PUNCT
ajbspi-134509	28	13	reviews	review	NOUN
ajbspi-134509	28	14	,	,	PUNCT
ajbspi-134509	28	15	and	and	CCONJ
ajbspi-134509	28	16	book	book	NOUN
ajbspi-134509	28	17	chapters	chapter	NOUN
ajbspi-134509	28	18	provided	provide	VERB
ajbspi-134509	28	19	by	by	ADP
ajbspi-134509	28	20	the	the	DET
ajbspi-134509	28	21	user	user	NOUN
ajbspi-134509	28	22	.	.	PUNCT
ajbspi-134509	29	1	search	search	NOUN
ajbspi-134509	29	2	strategy	strategy	NOUN
ajbspi-134509	29	3	and	and	CCONJ
ajbspi-134509	29	4	source	source	NOUN
ajbspi-134509	29	5	selection	selection	NOUN
ajbspi-134509	29	6	:	:	PUNCT
ajbspi-134509	29	7	the	the	DET
ajbspi-134509	29	8	provided	provide	VERB
ajbspi-134509	29	9	references	reference	NOUN
ajbspi-134509	29	10	formed	form	VERB
ajbspi-134509	29	11	the	the	DET
ajbspi-134509	29	12	exclusive	exclusive	ADJ
ajbspi-134509	29	13	basis	basis	NOUN
ajbspi-134509	29	14	for	for	ADP
ajbspi-134509	29	15	this	this	DET
ajbspi-134509	29	16	review	review	NOUN
ajbspi-134509	29	17	.	.	PUNCT
ajbspi-134509	30	1	no	no	DET
ajbspi-134509	30	2	additional	additional	ADJ
ajbspi-134509	30	3	external	external	ADJ
ajbspi-134509	30	4	database	database	NOUN
ajbspi-134509	30	5	searches	search	NOUN
ajbspi-134509	30	6	were	be	AUX
ajbspi-134509	30	7	performed	perform	VERB
ajbspi-134509	30	8	.	.	PUNCT
ajbspi-134509	31	1	the	the	DET
ajbspi-134509	31	2	selection	selection	NOUN
ajbspi-134509	31	3	of	of	ADP
ajbspi-134509	31	4	content	content	NOUN
ajbspi-134509	31	5	for	for	ADP
ajbspi-134509	31	6	inclusion	inclusion	NOUN
ajbspi-134509	31	7	in	in	ADP
ajbspi-134509	31	8	the	the	DET
ajbspi-134509	31	9	review	review	NOUN
ajbspi-134509	31	10	was	be	AUX
ajbspi-134509	31	11	based	base	VERB
ajbspi-134509	31	12	on	on	ADP
ajbspi-134509	31	13	the	the	DET
ajbspi-134509	31	14	direct	direct	ADJ
ajbspi-134509	31	15	relevance	relevance	NOUN
ajbspi-134509	31	16	of	of	ADP
ajbspi-134509	31	17	the	the	DET
ajbspi-134509	31	18	information	information	NOUN
ajbspi-134509	31	19	within	within	ADP
ajbspi-134509	31	20	these	these	DET
ajbspi-134509	31	21	provided	provide	VERB
ajbspi-134509	31	22	sources	source	NOUN
ajbspi-134509	31	23	to	to	ADP
ajbspi-134509	31	24	the	the	DET
ajbspi-134509	31	25	following	follow	VERB
ajbspi-134509	31	26	key	key	ADJ
ajbspi-134509	31	27	areas	area	NOUN
ajbspi-134509	31	28	:	:	PUNCT
ajbspi-134509	31	29	•	•	NUM
ajbspi-134509	31	30	fundamental	fundamental	ADJ
ajbspi-134509	31	31	aspects	aspect	NOUN
ajbspi-134509	31	32	of	of	ADP
ajbspi-134509	31	33	adenosine	adenosine	ADJ
ajbspi-134509	31	34	biochemistry	biochemistry	NOUN
ajbspi-134509	31	35	,	,	PUNCT
ajbspi-134509	31	36	metabolism	metabolism	NOUN
ajbspi-134509	31	37	,	,	PUNCT
ajbspi-134509	31	38	and	and	CCONJ
ajbspi-134509	31	39	transport	transport	NOUN
ajbspi-134509	31	40	.	.	PUNCT
ajbspi-134509	32	1	•	•	NUM
ajbspi-134509	32	2	characterization	characterization	NOUN
ajbspi-134509	32	3	and	and	CCONJ
ajbspi-134509	32	4	pharmacology	pharmacology	NOUN
ajbspi-134509	32	5	of	of	ADP
ajbspi-134509	32	6	adenosine	adenosine	ADJ
ajbspi-134509	32	7	receptors	receptor	NOUN
ajbspi-134509	32	8	.	.	PUNCT
ajbspi-134509	33	1	•	•	NUM
ajbspi-134509	33	2	the	the	DET
ajbspi-134509	33	3	diverse	diverse	ADJ
ajbspi-134509	33	4	immunomodulatory	immunomodulatory	ADJ
ajbspi-134509	33	5	functions	function	NOUN
ajbspi-134509	33	6	of	of	ADP
ajbspi-134509	33	7	adenosine	adenosine	NOUN
ajbspi-134509	33	8	on	on	ADP
ajbspi-134509	33	9	various	various	ADJ
ajbspi-134509	33	10	immune	immune	ADJ
ajbspi-134509	33	11	cell	cell	NOUN
ajbspi-134509	33	12	types	type	NOUN
ajbspi-134509	33	13	(	(	PUNCT
ajbspi-134509	33	14	e.g.	e.g.	ADV
ajbspi-134509	33	15	,	,	PUNCT
ajbspi-134509	33	16	neutrophils	neutrophil	NOUN
ajbspi-134509	33	17	,	,	PUNCT
ajbspi-134509	33	18	macrophages	macrophage	NOUN
ajbspi-134509	33	19	,	,	PUNCT
ajbspi-134509	33	20	dendritic	dendritic	ADJ
ajbspi-134509	33	21	cells	cell	NOUN
ajbspi-134509	33	22	,	,	PUNCT
ajbspi-134509	33	23	t	t	NOUN
ajbspi-134509	33	24	cells	cell	NOUN
ajbspi-134509	33	25	,	,	PUNCT
ajbspi-134509	33	26	b	b	NOUN
ajbspi-134509	33	27	cells	cell	NOUN
ajbspi-134509	33	28	,	,	PUNCT
ajbspi-134509	33	29	nk	nk	PROPN
ajbspi-134509	33	30	cells	cell	NOUN
ajbspi-134509	33	31	,	,	PUNCT
ajbspi-134509	33	32	mdscs	mdsc	NOUN
ajbspi-134509	33	33	,	,	PUNCT
ajbspi-134509	33	34	mast	mast	NOUN
ajbspi-134509	33	35	cells	cell	NOUN
ajbspi-134509	33	36	)	)	PUNCT
ajbspi-134509	33	37	.	.	PUNCT
ajbspi-134509	34	1	•	•	NUM
ajbspi-134509	34	2	the	the	DET
ajbspi-134509	34	3	role	role	NOUN
ajbspi-134509	34	4	of	of	ADP
ajbspi-134509	34	5	ectonucleotidases	ectonucleotidase	NOUN
ajbspi-134509	34	6	(	(	PUNCT
ajbspi-134509	34	7	cd39	cd39	PROPN
ajbspi-134509	34	8	,	,	PUNCT
ajbspi-134509	34	9	cd73	cd73	PROPN
ajbspi-134509	34	10	)	)	PUNCT
ajbspi-134509	34	11	in	in	ADP
ajbspi-134509	34	12	purinergic	purinergic	NOUN
ajbspi-134509	34	13	signaling	signal	VERB
ajbspi-134509	34	14	.	.	PUNCT
ajbspi-134509	35	1	•	•	NUM
ajbspi-134509	35	2	the	the	DET
ajbspi-134509	35	3	concept	concept	NOUN
ajbspi-134509	35	4	of	of	ADP
ajbspi-134509	35	5	atp	atp	PROPN
ajbspi-134509	35	6	as	as	ADP
ajbspi-134509	35	7	a	a	DET
ajbspi-134509	35	8	damp	damp	NOUN
ajbspi-134509	35	9	and	and	CCONJ
ajbspi-134509	35	10	its	its	PRON
ajbspi-134509	35	11	conversion	conversion	NOUN
ajbspi-134509	35	12	to	to	PART
ajbspi-134509	35	13	adenosine	adenosine	VERB
ajbspi-134509	35	14	in	in	ADP
ajbspi-134509	35	15	inflammatory	inflammatory	ADJ
ajbspi-134509	35	16	contexts	contexts	NOUN
ajbspi-134509	35	17	.	.	PUNCT
ajbspi-134509	36	1	•	•	NUM
ajbspi-134509	36	2	any	any	DET
ajbspi-134509	36	3	direct	direct	ADJ
ajbspi-134509	36	4	or	or	CCONJ
ajbspi-134509	36	5	indirect	indirect	ADJ
ajbspi-134509	36	6	implications	implication	NOUN
ajbspi-134509	36	7	for	for	ADP
ajbspi-134509	36	8	hostpathogen	hostpathogen	NOUN
ajbspi-134509	36	9	interactions	interaction	NOUN
ajbspi-134509	36	10	,	,	PUNCT
ajbspi-134509	36	11	particularly	particularly	ADV
ajbspi-134509	36	12	in	in	ADP
ajbspi-134509	36	13	inflammatory	inflammatory	ADJ
ajbspi-134509	36	14	settings	setting	NOUN
ajbspi-134509	36	15	relevant	relevant	ADJ
ajbspi-134509	36	16	to	to	ADP
ajbspi-134509	36	17	bacterial	bacterial	ADJ
ajbspi-134509	36	18	infections	infection	NOUN
ajbspi-134509	36	19	.	.	PUNCT
ajbspi-134509	37	1	data	datum	NOUN
ajbspi-134509	37	2	extraction	extraction	NOUN
ajbspi-134509	37	3	and	and	CCONJ
ajbspi-134509	37	4	synthesis	synthesis	NOUN
ajbspi-134509	37	5	:	:	PUNCT
ajbspi-134509	37	6	information	information	NOUN
ajbspi-134509	37	7	pertinent	pertinent	ADJ
ajbspi-134509	37	8	to	to	ADP
ajbspi-134509	37	9	the	the	DET
ajbspi-134509	37	10	aforementioned	aforementioned	ADJ
ajbspi-134509	37	11	themes	theme	NOUN
ajbspi-134509	37	12	was	be	AUX
ajbspi-134509	37	13	meticulously	meticulously	ADV
ajbspi-134509	37	14	extracted	extract	VERB
ajbspi-134509	37	15	from	from	ADP
ajbspi-134509	37	16	each	each	DET
ajbspi-134509	37	17	reference	reference	NOUN
ajbspi-134509	37	18	.	.	PUNCT
ajbspi-134509	38	1	this	this	PRON
ajbspi-134509	38	2	involved	involve	VERB
ajbspi-134509	38	3	identifying	identify	VERB
ajbspi-134509	38	4	key	key	ADJ
ajbspi-134509	38	5	concepts	concept	NOUN
ajbspi-134509	38	6	,	,	PUNCT
ajbspi-134509	38	7	experimental	experimental	ADJ
ajbspi-134509	38	8	findings	finding	NOUN
ajbspi-134509	38	9	,	,	PUNCT
ajbspi-134509	38	10	proposed	propose	VERB
ajbspi-134509	38	11	mechanisms	mechanism	NOUN
ajbspi-134509	38	12	,	,	PUNCT
ajbspi-134509	38	13	and	and	CCONJ
ajbspi-134509	38	14	clinical	clinical	ADJ
ajbspi-134509	38	15	implications	implication	NOUN
ajbspi-134509	38	16	related	relate	VERB
ajbspi-134509	38	17	to	to	PART
ajbspi-134509	38	18	adenosine	adenosine	VERB
ajbspi-134509	38	19	and	and	CCONJ
ajbspi-134509	38	20	its	its	PRON
ajbspi-134509	38	21	role	role	NOUN
ajbspi-134509	38	22	in	in	ADP
ajbspi-134509	38	23	immune	immune	ADJ
ajbspi-134509	38	24	regulation	regulation	NOUN
ajbspi-134509	38	25	.	.	PUNCT
ajbspi-134509	39	1	the	the	DET
ajbspi-134509	39	2	extracted	extract	VERB
ajbspi-134509	39	3	data	datum	NOUN
ajbspi-134509	39	4	were	be	AUX
ajbspi-134509	39	5	then	then	ADV
ajbspi-134509	39	6	organized	organize	VERB
ajbspi-134509	39	7	thematically	thematically	ADV
ajbspi-134509	39	8	to	to	PART
ajbspi-134509	39	9	construct	construct	VERB
ajbspi-134509	39	10	a	a	DET
ajbspi-134509	39	11	coherent	coherent	ADJ
ajbspi-134509	39	12	narrative	narrative	NOUN
ajbspi-134509	39	13	that	that	PRON
ajbspi-134509	39	14	progresses	progress	VERB
ajbspi-134509	39	15	from	from	ADP
ajbspi-134509	39	16	the	the	DET
ajbspi-134509	39	17	basic	basic	ADJ
ajbspi-134509	39	18	understanding	understanding	NOUN
ajbspi-134509	39	19	of	of	ADP
ajbspi-134509	39	20	the	the	DET
ajbspi-134509	39	21	adenosine	adenosine	NOUN
ajbspi-134509	39	22	system	system	NOUN
ajbspi-134509	39	23	to	to	ADP
ajbspi-134509	39	24	its	its	PRON
ajbspi-134509	39	25	complex	complex	ADJ
ajbspi-134509	39	26	immunomodulatory	immunomodulatory	ADJ
ajbspi-134509	39	27	functions	function	NOUN
ajbspi-134509	39	28	,	,	PUNCT
ajbspi-134509	39	29	and	and	CCONJ
ajbspi-134509	39	30	finally	finally	ADV
ajbspi-134509	39	31	to	to	ADP
ajbspi-134509	39	32	its	its	PRON
ajbspi-134509	39	33	hypothesized	hypothesized	ADJ
ajbspi-134509	39	34	manipulation	manipulation	NOUN
ajbspi-134509	39	35	during	during	ADP
ajbspi-134509	39	36	c.	c.	PROPN
ajbspi-134509	39	37	difficile	difficile	PROPN
ajbspi-134509	39	38	infection	infection	NOUN
ajbspi-134509	39	39	.	.	PUNCT
ajbspi-134509	40	1	analytical	analytical	ADJ
ajbspi-134509	40	2	approach	approach	NOUN
ajbspi-134509	40	3	:	:	PUNCT
ajbspi-134509	40	4	a	a	DET
ajbspi-134509	40	5	qualitative	qualitative	ADJ
ajbspi-134509	40	6	and	and	CCONJ
ajbspi-134509	40	7	thematic	thematic	ADJ
ajbspi-134509	40	8	analytical	analytical	ADJ
ajbspi-134509	40	9	approach	approach	NOUN
ajbspi-134509	40	10	was	be	AUX
ajbspi-134509	40	11	employed	employ	VERB
ajbspi-134509	40	12	.	.	PUNCT
ajbspi-134509	41	1	the	the	DET
ajbspi-134509	41	2	extracted	extract	VERB
ajbspi-134509	41	3	information	information	NOUN
ajbspi-134509	41	4	was	be	AUX
ajbspi-134509	41	5	critically	critically	ADV
ajbspi-134509	41	6	evaluated	evaluate	VERB
ajbspi-134509	41	7	and	and	CCONJ
ajbspi-134509	41	8	synthesized	synthesize	VERB
ajbspi-134509	41	9	to	to	PART
ajbspi-134509	41	10	identify	identify	VERB
ajbspi-134509	41	11	overarching	overarching	ADJ
ajbspi-134509	41	12	patterns	pattern	NOUN
ajbspi-134509	41	13	,	,	PUNCT
ajbspi-134509	41	14	common	common	ADJ
ajbspi-134509	41	15	mechanisms	mechanism	NOUN
ajbspi-134509	41	16	,	,	PUNCT
ajbspi-134509	41	17	and	and	CCONJ
ajbspi-134509	41	18	potential	potential	ADJ
ajbspi-134509	41	19	connections	connection	NOUN
ajbspi-134509	41	20	between	between	ADP
ajbspi-134509	41	21	the	the	DET
ajbspi-134509	41	22	host	host	NOUN
ajbspi-134509	41	23	adenosine	adenosine	NOUN
ajbspi-134509	41	24	system	system	NOUN
ajbspi-134509	41	25	and	and	CCONJ
ajbspi-134509	41	26	the	the	DET
ajbspi-134509	41	27	pathogenesis	pathogenesis	NOUN
ajbspi-134509	41	28	of	of	ADP
ajbspi-134509	41	29	c.	c.	PROPN
ajbspi-134509	41	30	difficile	difficile	PROPN
ajbspi-134509	41	31	.	.	PUNCT
ajbspi-134509	42	1	while	while	SCONJ
ajbspi-134509	42	2	the	the	DET
ajbspi-134509	42	3	provided	provide	VERB
ajbspi-134509	42	4	references	reference	NOUN
ajbspi-134509	42	5	do	do	AUX
ajbspi-134509	42	6	not	not	PART
ajbspi-134509	42	7	directly	directly	ADV
ajbspi-134509	42	8	detail	detail	VERB
ajbspi-134509	42	9	c.	c.	PROPN
ajbspi-134509	42	10	difficile	difficile	PROPN
ajbspi-134509	42	11	's	's	PART
ajbspi-134509	42	12	specific	specific	ADJ
ajbspi-134509	42	13	manipulation	manipulation	NOUN
ajbspi-134509	42	14	of	of	ADP
ajbspi-134509	42	15	adenosine	adenosine	NOUN
ajbspi-134509	42	16	,	,	PUNCT
ajbspi-134509	42	17	the	the	DET
ajbspi-134509	42	18	review	review	NOUN
ajbspi-134509	42	19	infers	infer	VERB
ajbspi-134509	42	20	potential	potential	ADJ
ajbspi-134509	42	21	mechanisms	mechanism	NOUN
ajbspi-134509	42	22	based	base	VERB
ajbspi-134509	42	23	on	on	ADP
ajbspi-134509	42	24	the	the	DET
ajbspi-134509	42	25	known	know	VERB
ajbspi-134509	42	26	inflammatory	inflammatory	ADJ
ajbspi-134509	42	27	environment	environment	NOUN
ajbspi-134509	42	28	of	of	ADP
ajbspi-134509	42	29	cdi	cdi	PROPN
ajbspi-134509	42	30	and	and	CCONJ
ajbspi-134509	42	31	the	the	DET
ajbspi-134509	42	32	established	establish	VERB
ajbspi-134509	42	33	immunomodulatory	immunomodulatory	ADJ
ajbspi-134509	42	34	properties	property	NOUN
ajbspi-134509	42	35	of	of	ADP
ajbspi-134509	42	36	adenosine	adenosine	NOUN
ajbspi-134509	42	37	,	,	PUNCT
ajbspi-134509	42	38	as	as	SCONJ
ajbspi-134509	42	39	described	describe	VERB
ajbspi-134509	42	40	in	in	ADP
ajbspi-134509	42	41	the	the	DET
ajbspi-134509	42	42	cited	cite	VERB
ajbspi-134509	42	43	literature	literature	NOUN
ajbspi-134509	42	44	.	.	PUNCT
ajbspi-134509	43	1	the	the	DET
ajbspi-134509	43	2	aim	aim	NOUN
ajbspi-134509	43	3	was	be	AUX
ajbspi-134509	43	4	to	to	PART
ajbspi-134509	43	5	build	build	VERB
ajbspi-134509	43	6	a	a	DET
ajbspi-134509	43	7	comprehensive	comprehensive	ADJ
ajbspi-134509	43	8	theoretical	theoretical	ADJ
ajbspi-134509	43	9	framework	framework	NOUN
ajbspi-134509	43	10	for	for	ADP
ajbspi-134509	43	11	how	how	SCONJ
ajbspi-134509	43	12	such	such	ADJ
ajbspi-134509	43	13	manipulation	manipulation	NOUN
ajbspi-134509	43	14	could	could	AUX
ajbspi-134509	43	15	occur	occur	VERB
ajbspi-134509	43	16	and	and	CCONJ
ajbspi-134509	43	17	its	its	PRON
ajbspi-134509	43	18	potential	potential	ADJ
ajbspi-134509	43	19	consequences	consequence	NOUN
ajbspi-134509	43	20	for	for	ADP
ajbspi-134509	43	21	the	the	DET
ajbspi-134509	43	22	host	host	NOUN
ajbspi-134509	43	23	.	.	PUNCT
ajbspi-134509	44	1	all	all	DET
ajbspi-134509	44	2	interpretations	interpretation	NOUN
ajbspi-134509	44	3	and	and	CCONJ
ajbspi-134509	44	4	discussions	discussion	NOUN
ajbspi-134509	44	5	are	be	AUX
ajbspi-134509	44	6	grounded	ground	VERB
ajbspi-134509	44	7	in	in	ADP
ajbspi-134509	44	8	the	the	DET
ajbspi-134509	44	9	evidence	evidence	NOUN
ajbspi-134509	44	10	presented	present	VERB
ajbspi-134509	44	11	within	within	ADP
ajbspi-134509	44	12	the	the	DET
ajbspi-134509	44	13	provided	provide	VERB
ajbspi-134509	44	14	bibliography	bibliography	NOUN
ajbspi-134509	44	15	,	,	PUNCT
ajbspi-134509	44	16	ensuring	ensure	VERB
ajbspi-134509	44	17	that	that	SCONJ
ajbspi-134509	44	18	the	the	DET
ajbspi-134509	44	19	review	review	NOUN
ajbspi-134509	44	20	remains	remain	VERB
ajbspi-134509	44	21	within	within	ADP
ajbspi-134509	44	22	the	the	DET
ajbspi-134509	44	23	scope	scope	NOUN
ajbspi-134509	44	24	of	of	ADP
ajbspi-134509	44	25	the	the	DET
ajbspi-134509	44	26	given	give	VERB
ajbspi-134509	44	27	source	source	NOUN
ajbspi-134509	44	28	material	material	NOUN
ajbspi-134509	44	29	.	.	PUNCT
ajbspi-134509	45	1	results	result	VERB
ajbspi-134509	45	2	the	the	DET
ajbspi-134509	45	3	comprehensive	comprehensive	ADJ
ajbspi-134509	45	4	analysis	analysis	NOUN
ajbspi-134509	45	5	of	of	ADP
ajbspi-134509	45	6	the	the	DET
ajbspi-134509	45	7	provided	provide	VERB
ajbspi-134509	45	8	literature	literature	NOUN
ajbspi-134509	45	9	reveals	reveal	VERB
ajbspi-134509	45	10	the	the	DET
ajbspi-134509	45	11	intricate	intricate	ADJ
ajbspi-134509	45	12	nature	nature	NOUN
ajbspi-134509	45	13	of	of	ADP
ajbspi-134509	45	14	the	the	DET
ajbspi-134509	45	15	adenosine	adenosine	NOUN
ajbspi-134509	45	16	system	system	NOUN
ajbspi-134509	45	17	,	,	PUNCT
ajbspi-134509	45	18	its	its	PRON
ajbspi-134509	45	19	american	american	ADJ
ajbspi-134509	45	20	journal	journal	NOUN
ajbspi-134509	45	21	of	of	ADP
ajbspi-134509	45	22	applied	apply	VERB
ajbspi-134509	45	23	science	science	NOUN
ajbspi-134509	45	24	and	and	CCONJ
ajbspi-134509	45	25	technology	technology	NOUN
ajbspi-134509	45	26	3	3	NUM
ajbspi-134509	45	27	https://theusajournals.com/index.php/ajast	https://theusajournals.com/index.php/ajast	VERB
ajbspi-134509	45	28	american	american	PROPN
ajbspi-134509	45	29	journal	journal	PROPN
ajbspi-134509	45	30	of	of	ADP
ajbspi-134509	45	31	applied	apply	VERB
ajbspi-134509	45	32	science	science	NOUN
ajbspi-134509	45	33	and	and	CCONJ
ajbspi-134509	45	34	technology	technology	NOUN
ajbspi-134509	45	35	(	(	PUNCT
ajbspi-134509	45	36	issn	issn	PROPN
ajbspi-134509	45	37	:	:	PUNCT
ajbspi-134509	45	38	2771	2771	NUM
ajbspi-134509	45	39	-	-	SYM
ajbspi-134509	45	40	2745	2745	NUM
ajbspi-134509	45	41	)	)	PUNCT
ajbspi-134509	45	42	profound	profound	ADJ
ajbspi-134509	45	43	immunomodulatory	immunomodulatory	ADJ
ajbspi-134509	45	44	capabilities	capability	NOUN
ajbspi-134509	45	45	,	,	PUNCT
ajbspi-134509	45	46	and	and	CCONJ
ajbspi-134509	45	47	the	the	DET
ajbspi-134509	45	48	potential	potential	ADJ
ajbspi-134509	45	49	implications	implication	NOUN
ajbspi-134509	45	50	for	for	ADP
ajbspi-134509	45	51	host	host	NOUN
ajbspi-134509	45	52	-	-	PUNCT
ajbspi-134509	45	53	pathogen	pathogen	NOUN
ajbspi-134509	45	54	interactions	interaction	NOUN
ajbspi-134509	45	55	,	,	PUNCT
ajbspi-134509	45	56	particularly	particularly	ADV
ajbspi-134509	45	57	in	in	ADP
ajbspi-134509	45	58	inflammatory	inflammatory	ADJ
ajbspi-134509	45	59	contexts	context	NOUN
ajbspi-134509	45	60	such	such	ADJ
ajbspi-134509	45	61	as	as	ADP
ajbspi-134509	45	62	clostridioides	clostridioide	NOUN
ajbspi-134509	45	63	difficile	difficile	VERB
ajbspi-134509	45	64	infection	infection	NOUN
ajbspi-134509	45	65	.	.	PUNCT
ajbspi-134509	46	1	the	the	DET
ajbspi-134509	46	2	findings	finding	NOUN
ajbspi-134509	46	3	are	be	AUX
ajbspi-134509	46	4	presented	present	VERB
ajbspi-134509	46	5	in	in	ADP
ajbspi-134509	46	6	a	a	DET
ajbspi-134509	46	7	structured	structured	ADJ
ajbspi-134509	46	8	manner	manner	NOUN
ajbspi-134509	46	9	,	,	PUNCT
ajbspi-134509	46	10	beginning	begin	VERB
ajbspi-134509	46	11	with	with	ADP
ajbspi-134509	46	12	the	the	DET
ajbspi-134509	46	13	fundamental	fundamental	ADJ
ajbspi-134509	46	14	aspects	aspect	NOUN
ajbspi-134509	46	15	of	of	ADP
ajbspi-134509	46	16	adenosine	adenosine	NOUN
ajbspi-134509	46	17	signaling	signal	VERB
ajbspi-134509	46	18	and	and	CCONJ
ajbspi-134509	46	19	progressing	progress	VERB
ajbspi-134509	46	20	to	to	ADP
ajbspi-134509	46	21	its	its	PRON
ajbspi-134509	46	22	specific	specific	ADJ
ajbspi-134509	46	23	effects	effect	NOUN
ajbspi-134509	46	24	on	on	ADP
ajbspi-134509	46	25	various	various	ADJ
ajbspi-134509	46	26	immune	immune	ADJ
ajbspi-134509	46	27	cell	cell	NOUN
ajbspi-134509	46	28	populations	population	NOUN
ajbspi-134509	46	29	.	.	PUNCT
ajbspi-134509	47	1	the	the	DET
ajbspi-134509	47	2	adenosine	adenosine	NOUN
ajbspi-134509	47	3	system	system	NOUN
ajbspi-134509	47	4	:	:	PUNCT
ajbspi-134509	47	5	a	a	DET
ajbspi-134509	47	6	master	master	NOUN
ajbspi-134509	47	7	regulator	regulator	NOUN
ajbspi-134509	47	8	of	of	ADP
ajbspi-134509	47	9	host	host	NOUN
ajbspi-134509	47	10	homeostasis	homeostasis	NOUN
ajbspi-134509	47	11	adenosine	adenosine	NOUN
ajbspi-134509	47	12	is	be	AUX
ajbspi-134509	47	13	a	a	DET
ajbspi-134509	47	14	purine	purine	NOUN
ajbspi-134509	47	15	nucleoside	nucleoside	NOUN
ajbspi-134509	47	16	that	that	PRON
ajbspi-134509	47	17	plays	play	VERB
ajbspi-134509	47	18	a	a	DET
ajbspi-134509	47	19	critical	critical	ADJ
ajbspi-134509	47	20	role	role	NOUN
ajbspi-134509	47	21	in	in	ADP
ajbspi-134509	47	22	cellular	cellular	ADJ
ajbspi-134509	47	23	metabolism	metabolism	NOUN
ajbspi-134509	47	24	and	and	CCONJ
ajbspi-134509	47	25	signaling	signal	VERB
ajbspi-134509	47	26	,	,	PUNCT
ajbspi-134509	47	27	acting	act	VERB
ajbspi-134509	47	28	as	as	ADP
ajbspi-134509	47	29	an	an	DET
ajbspi-134509	47	30	endogenous	endogenous	ADJ
ajbspi-134509	47	31	signaling	signal	VERB
ajbspi-134509	47	32	molecule	molecule	NOUN
ajbspi-134509	47	33	that	that	PRON
ajbspi-134509	47	34	modulates	modulate	VERB
ajbspi-134509	47	35	a	a	DET
ajbspi-134509	47	36	wide	wide	ADJ
ajbspi-134509	47	37	array	array	NOUN
ajbspi-134509	47	38	of	of	ADP
ajbspi-134509	47	39	physiological	physiological	ADJ
ajbspi-134509	47	40	and	and	CCONJ
ajbspi-134509	47	41	pathophysiological	pathophysiological	ADJ
ajbspi-134509	47	42	processes	process	NOUN
ajbspi-134509	47	43	,	,	PUNCT
ajbspi-134509	47	44	including	include	VERB
ajbspi-134509	47	45	inflammation	inflammation	NOUN
ajbspi-134509	47	46	,	,	PUNCT
ajbspi-134509	47	47	tissue	tissue	NOUN
ajbspi-134509	47	48	damage	damage	NOUN
ajbspi-134509	47	49	,	,	PUNCT
ajbspi-134509	47	50	and	and	CCONJ
ajbspi-134509	47	51	repair	repair	VERB
ajbspi-134509	47	52	[	[	X
ajbspi-134509	47	53	1	1	NUM
ajbspi-134509	47	54	,	,	PUNCT
ajbspi-134509	47	55	5	5	NUM
ajbspi-134509	47	56	]	]	PUNCT
ajbspi-134509	47	57	.	.	PUNCT
ajbspi-134509	48	1	often	often	ADV
ajbspi-134509	48	2	referred	refer	VERB
ajbspi-134509	48	3	to	to	ADP
ajbspi-134509	48	4	as	as	ADP
ajbspi-134509	48	5	a	a	DET
ajbspi-134509	48	6	"	"	PUNCT
ajbspi-134509	48	7	retaliatory	retaliatory	ADJ
ajbspi-134509	48	8	metabolite	metabolite	NOUN
ajbspi-134509	48	9	"	"	PUNCT
ajbspi-134509	48	10	or	or	CCONJ
ajbspi-134509	48	11	"	"	PUNCT
ajbspi-134509	48	12	distress	distress	NOUN
ajbspi-134509	48	13	signal	signal	NOUN
ajbspi-134509	48	14	,	,	PUNCT
ajbspi-134509	48	15	"	"	PUNCT
ajbspi-134509	48	16	adenosine	adenosine	ADJ
ajbspi-134509	48	17	levels	level	NOUN
ajbspi-134509	48	18	significantly	significantly	ADV
ajbspi-134509	48	19	increase	increase	VERB
ajbspi-134509	48	20	in	in	ADP
ajbspi-134509	48	21	response	response	NOUN
ajbspi-134509	48	22	to	to	ADP
ajbspi-134509	48	23	cellular	cellular	ADJ
ajbspi-134509	48	24	stress	stress	NOUN
ajbspi-134509	48	25	,	,	PUNCT
ajbspi-134509	48	26	hypoxia	hypoxia	NOUN
ajbspi-134509	48	27	,	,	PUNCT
ajbspi-134509	48	28	and	and	CCONJ
ajbspi-134509	48	29	inflammation	inflammation	NOUN
ajbspi-134509	48	30	,	,	PUNCT
ajbspi-134509	48	31	serving	serve	VERB
ajbspi-134509	48	32	to	to	PART
ajbspi-134509	48	33	protect	protect	VERB
ajbspi-134509	48	34	tissues	tissue	NOUN
ajbspi-134509	48	35	from	from	ADP
ajbspi-134509	48	36	excessive	excessive	ADJ
ajbspi-134509	48	37	damage	damage	NOUN
ajbspi-134509	48	38	and	and	CCONJ
ajbspi-134509	48	39	to	to	PART
ajbspi-134509	48	40	restore	restore	VERB
ajbspi-134509	48	41	homeostasis	homeostasis	NOUN
ajbspi-134509	48	42	[	[	X
ajbspi-134509	48	43	1	1	NUM
ajbspi-134509	48	44	,	,	PUNCT
ajbspi-134509	48	45	15	15	NUM
ajbspi-134509	48	46	]	]	PUNCT
ajbspi-134509	48	47	.	.	PUNCT
ajbspi-134509	49	1	adenosine	adenosine	NOUN
ajbspi-134509	49	2	generation	generation	NOUN
ajbspi-134509	49	3	and	and	CCONJ
ajbspi-134509	49	4	metabolism	metabolism	NOUN
ajbspi-134509	49	5	the	the	DET
ajbspi-134509	49	6	extracellular	extracellular	ADJ
ajbspi-134509	49	7	concentration	concentration	NOUN
ajbspi-134509	49	8	of	of	ADP
ajbspi-134509	49	9	adenosine	adenosine	NOUN
ajbspi-134509	49	10	is	be	AUX
ajbspi-134509	49	11	tightly	tightly	ADV
ajbspi-134509	49	12	regulated	regulate	VERB
ajbspi-134509	49	13	by	by	ADP
ajbspi-134509	49	14	a	a	DET
ajbspi-134509	49	15	complex	complex	ADJ
ajbspi-134509	49	16	enzymatic	enzymatic	ADJ
ajbspi-134509	49	17	cascade	cascade	NOUN
ajbspi-134509	49	18	,	,	PUNCT
ajbspi-134509	49	19	primarily	primarily	ADV
ajbspi-134509	49	20	involving	involve	VERB
ajbspi-134509	49	21	ectonucleotidases	ectonucleotidase	NOUN
ajbspi-134509	49	22	located	locate	VERB
ajbspi-134509	49	23	on	on	ADP
ajbspi-134509	49	24	the	the	DET
ajbspi-134509	49	25	cell	cell	NOUN
ajbspi-134509	49	26	surface	surface	NOUN
ajbspi-134509	50	1	[	[	X
ajbspi-134509	50	2	6	6	NUM
ajbspi-134509	50	3	,	,	PUNCT
ajbspi-134509	50	4	7	7	NUM
ajbspi-134509	50	5	]	]	PUNCT
ajbspi-134509	50	6	.	.	PUNCT
ajbspi-134509	51	1	the	the	DET
ajbspi-134509	51	2	process	process	NOUN
ajbspi-134509	51	3	typically	typically	ADV
ajbspi-134509	51	4	begins	begin	VERB
ajbspi-134509	51	5	with	with	ADP
ajbspi-134509	51	6	the	the	DET
ajbspi-134509	51	7	release	release	NOUN
ajbspi-134509	51	8	of	of	ADP
ajbspi-134509	51	9	atp	atp	PROPN
ajbspi-134509	51	10	from	from	ADP
ajbspi-134509	51	11	cells	cell	NOUN
ajbspi-134509	51	12	,	,	PUNCT
ajbspi-134509	51	13	which	which	PRON
ajbspi-134509	51	14	can	can	AUX
ajbspi-134509	51	15	occur	occur	VERB
ajbspi-134509	51	16	under	under	ADP
ajbspi-134509	51	17	various	various	ADJ
ajbspi-134509	51	18	physiological	physiological	ADJ
ajbspi-134509	51	19	conditions	condition	NOUN
ajbspi-134509	51	20	(	(	PUNCT
ajbspi-134509	51	21	e.g.	e.g.	ADV
ajbspi-134509	51	22	,	,	PUNCT
ajbspi-134509	51	23	neurotransmission	neurotransmission	NOUN
ajbspi-134509	51	24	)	)	PUNCT
ajbspi-134509	51	25	but	but	CCONJ
ajbspi-134509	51	26	is	be	AUX
ajbspi-134509	51	27	dramatically	dramatically	ADV
ajbspi-134509	51	28	increased	increase	VERB
ajbspi-134509	51	29	during	during	ADP
ajbspi-134509	51	30	cellular	cellular	ADJ
ajbspi-134509	51	31	stress	stress	NOUN
ajbspi-134509	51	32	,	,	PUNCT
ajbspi-134509	51	33	injury	injury	NOUN
ajbspi-134509	51	34	,	,	PUNCT
ajbspi-134509	51	35	or	or	CCONJ
ajbspi-134509	51	36	inflammation	inflammation	NOUN
ajbspi-134509	51	37	[	[	X
ajbspi-134509	51	38	59	59	NUM
ajbspi-134509	51	39	,	,	PUNCT
ajbspi-134509	51	40	60	60	NUM
ajbspi-134509	51	41	,	,	PUNCT
ajbspi-134509	51	42	61	61	NUM
ajbspi-134509	51	43	,	,	PUNCT
ajbspi-134509	51	44	62	62	NUM
ajbspi-134509	51	45	,	,	PUNCT
ajbspi-134509	51	46	63	63	NUM
ajbspi-134509	51	47	,	,	PUNCT
ajbspi-134509	51	48	64	64	NUM
ajbspi-134509	51	49	,	,	PUNCT
ajbspi-134509	51	50	65	65	NUM
ajbspi-134509	51	51	,	,	PUNCT
ajbspi-134509	51	52	66	66	NUM
ajbspi-134509	51	53	]	]	PUNCT
ajbspi-134509	51	54	.	.	PUNCT
ajbspi-134509	52	1	atp	atp	PROPN
ajbspi-134509	52	2	,	,	PUNCT
ajbspi-134509	52	3	when	when	SCONJ
ajbspi-134509	52	4	released	release	VERB
ajbspi-134509	52	5	into	into	ADP
ajbspi-134509	52	6	the	the	DET
ajbspi-134509	52	7	extracellular	extracellular	ADJ
ajbspi-134509	52	8	space	space	NOUN
ajbspi-134509	52	9	,	,	PUNCT
ajbspi-134509	52	10	acts	act	VERB
ajbspi-134509	52	11	as	as	ADP
ajbspi-134509	52	12	a	a	DET
ajbspi-134509	52	13	potent	potent	ADJ
ajbspi-134509	52	14	pro	pro	ADJ
ajbspi-134509	52	15	-	-	ADJ
ajbspi-134509	52	16	inflammatory	inflammatory	ADJ
ajbspi-134509	52	17	damp	damp	NOUN
ajbspi-134509	52	18	,	,	PUNCT
ajbspi-134509	52	19	activating	activate	VERB
ajbspi-134509	52	20	purinergic	purinergic	NOUN
ajbspi-134509	52	21	receptors	receptor	NOUN
ajbspi-134509	52	22	and	and	CCONJ
ajbspi-134509	52	23	initiating	initiate	VERB
ajbspi-134509	52	24	immune	immune	ADJ
ajbspi-134509	52	25	responses	response	NOUN
ajbspi-134509	52	26	[	[	X
ajbspi-134509	52	27	59	59	NUM
ajbspi-134509	52	28	,	,	PUNCT
ajbspi-134509	52	29	60	60	NUM
ajbspi-134509	52	30	,	,	PUNCT
ajbspi-134509	52	31	61	61	NUM
ajbspi-134509	52	32	,	,	PUNCT
ajbspi-134509	52	33	62	62	NUM
ajbspi-134509	52	34	,	,	PUNCT
ajbspi-134509	52	35	63	63	NUM
ajbspi-134509	52	36	,	,	PUNCT
ajbspi-134509	52	37	64	64	NUM
ajbspi-134509	52	38	,	,	PUNCT
ajbspi-134509	52	39	65	65	NUM
ajbspi-134509	52	40	,	,	PUNCT
ajbspi-134509	52	41	66	66	NUM
ajbspi-134509	52	42	]	]	PUNCT
ajbspi-134509	52	43	.	.	PUNCT
ajbspi-134509	53	1	the	the	DET
ajbspi-134509	53	2	sequential	sequential	ADJ
ajbspi-134509	53	3	hydrolysis	hydrolysis	NOUN
ajbspi-134509	53	4	of	of	ADP
ajbspi-134509	53	5	extracellular	extracellular	ADJ
ajbspi-134509	53	6	atp	atp	NOUN
ajbspi-134509	53	7	to	to	PART
ajbspi-134509	53	8	adenosine	adenosine	VERB
ajbspi-134509	53	9	is	be	AUX
ajbspi-134509	53	10	mediated	mediate	VERB
ajbspi-134509	53	11	by	by	ADP
ajbspi-134509	53	12	two	two	NUM
ajbspi-134509	53	13	key	key	ADJ
ajbspi-134509	53	14	ectoenzymes	ectoenzyme	NOUN
ajbspi-134509	53	15	:	:	PUNCT
ajbspi-134509	54	1	1	1	NUM
ajbspi-134509	54	2	.	.	X
ajbspi-134509	54	3	cd39	cd39	PROPN
ajbspi-134509	54	4	(	(	PUNCT
ajbspi-134509	54	5	ectonucleoside	ectonucleoside	ADJ
ajbspi-134509	54	6	triphosphate	triphosphate	NOUN
ajbspi-134509	54	7	diphosphohydrolase-1	diphosphohydrolase-1	PROPN
ajbspi-134509	54	8	,	,	PUNCT
ajbspi-134509	54	9	entpd1	entpd1	NOUN
ajbspi-134509	54	10	):	):	PUNCT
ajbspi-134509	54	11	this	this	DET
ajbspi-134509	54	12	enzyme	enzyme	NOUN
ajbspi-134509	54	13	is	be	AUX
ajbspi-134509	54	14	responsible	responsible	ADJ
ajbspi-134509	54	15	for	for	ADP
ajbspi-134509	54	16	the	the	DET
ajbspi-134509	54	17	hydrolysis	hydrolysis	NOUN
ajbspi-134509	54	18	of	of	ADP
ajbspi-134509	54	19	atp	atp	PROPN
ajbspi-134509	54	20	and	and	CCONJ
ajbspi-134509	54	21	adp	adp	PROPN
ajbspi-134509	54	22	into	into	ADP
ajbspi-134509	54	23	amp	amp	PROPN
ajbspi-134509	55	1	[	[	X
ajbspi-134509	55	2	7	7	NUM
ajbspi-134509	55	3	,	,	PUNCT
ajbspi-134509	55	4	21	21	NUM
ajbspi-134509	55	5	,	,	PUNCT
ajbspi-134509	55	6	31	31	NUM
ajbspi-134509	55	7	,	,	PUNCT
ajbspi-134509	55	8	32	32	NUM
ajbspi-134509	55	9	]	]	PUNCT
ajbspi-134509	55	10	.	.	PUNCT
ajbspi-134509	56	1	cd39	cd39	PROPN
ajbspi-134509	56	2	is	be	AUX
ajbspi-134509	56	3	widely	widely	ADV
ajbspi-134509	56	4	expressed	express	VERB
ajbspi-134509	56	5	on	on	ADP
ajbspi-134509	56	6	various	various	ADJ
ajbspi-134509	56	7	cell	cell	NOUN
ajbspi-134509	56	8	types	type	NOUN
ajbspi-134509	56	9	,	,	PUNCT
ajbspi-134509	56	10	including	include	VERB
ajbspi-134509	56	11	endothelial	endothelial	ADJ
ajbspi-134509	56	12	cells	cell	NOUN
ajbspi-134509	56	13	,	,	PUNCT
ajbspi-134509	56	14	regulatory	regulatory	ADJ
ajbspi-134509	56	15	t	t	NOUN
ajbspi-134509	56	16	cells	cell	NOUN
ajbspi-134509	56	17	(	(	PUNCT
ajbspi-134509	56	18	tregs	treg	NOUN
ajbspi-134509	56	19	)	)	PUNCT
ajbspi-134509	56	20	,	,	PUNCT
ajbspi-134509	56	21	and	and	CCONJ
ajbspi-134509	56	22	myeloid	myeloid	ADJ
ajbspi-134509	56	23	-	-	PUNCT
ajbspi-134509	56	24	derived	derive	VERB
ajbspi-134509	56	25	suppressor	suppressor	NOUN
ajbspi-134509	56	26	cells	cell	NOUN
ajbspi-134509	56	27	(	(	PUNCT
ajbspi-134509	56	28	mdscs	mdsc	NOUN
ajbspi-134509	56	29	)	)	PUNCT
ajbspi-134509	56	30	,	,	PUNCT
ajbspi-134509	56	31	where	where	SCONJ
ajbspi-134509	56	32	it	it	PRON
ajbspi-134509	56	33	plays	play	VERB
ajbspi-134509	56	34	a	a	DET
ajbspi-134509	56	35	crucial	crucial	ADJ
ajbspi-134509	56	36	role	role	NOUN
ajbspi-134509	56	37	in	in	ADP
ajbspi-134509	56	38	regulating	regulate	VERB
ajbspi-134509	56	39	vascular	vascular	ADJ
ajbspi-134509	56	40	inflammation	inflammation	NOUN
ajbspi-134509	56	41	and	and	CCONJ
ajbspi-134509	56	42	thrombosis	thrombosis	NOUN
ajbspi-134509	56	43	[	[	X
ajbspi-134509	56	44	7	7	NUM
ajbspi-134509	56	45	,	,	PUNCT
ajbspi-134509	56	46	21	21	NUM
ajbspi-134509	56	47	,	,	PUNCT
ajbspi-134509	56	48	31	31	NUM
ajbspi-134509	56	49	,	,	PUNCT
ajbspi-134509	56	50	32	32	NUM
ajbspi-134509	56	51	]	]	PUNCT
ajbspi-134509	56	52	.	.	PUNCT
ajbspi-134509	57	1	its	its	PRON
ajbspi-134509	57	2	activity	activity	NOUN
ajbspi-134509	57	3	is	be	AUX
ajbspi-134509	57	4	central	central	ADJ
ajbspi-134509	57	5	to	to	ADP
ajbspi-134509	57	6	dampening	dampen	VERB
ajbspi-134509	57	7	pro	pro	ADJ
ajbspi-134509	57	8	-	-	ADJ
ajbspi-134509	57	9	inflammatory	inflammatory	ADJ
ajbspi-134509	57	10	atp	atp	NOUN
ajbspi-134509	57	11	signaling	signal	VERB
ajbspi-134509	57	12	by	by	ADP
ajbspi-134509	57	13	rapidly	rapidly	ADV
ajbspi-134509	57	14	converting	convert	VERB
ajbspi-134509	57	15	it	it	PRON
ajbspi-134509	57	16	to	to	ADP
ajbspi-134509	57	17	a	a	DET
ajbspi-134509	57	18	less	less	ADV
ajbspi-134509	57	19	active	active	ADJ
ajbspi-134509	57	20	form	form	NOUN
ajbspi-134509	57	21	.	.	PUNCT
ajbspi-134509	58	1	2	2	X
ajbspi-134509	58	2	.	.	X
ajbspi-134509	58	3	cd73	cd73	PROPN
ajbspi-134509	58	4	(	(	PUNCT
ajbspi-134509	58	5	ecto-5'-nucleotidase	ecto-5'-nucleotidase	NOUN
ajbspi-134509	58	6	):	):	PUNCT
ajbspi-134509	58	7	following	follow	VERB
ajbspi-134509	58	8	the	the	DET
ajbspi-134509	58	9	action	action	NOUN
ajbspi-134509	58	10	of	of	ADP
ajbspi-134509	58	11	cd39	cd39	PROPN
ajbspi-134509	58	12	,	,	PUNCT
ajbspi-134509	58	13	cd73	cd73	PROPN
ajbspi-134509	58	14	catalyzes	catalyze	VERB
ajbspi-134509	58	15	the	the	DET
ajbspi-134509	58	16	dephosphorylation	dephosphorylation	NOUN
ajbspi-134509	58	17	of	of	ADP
ajbspi-134509	58	18	amp	amp	NOUN
ajbspi-134509	58	19	into	into	ADP
ajbspi-134509	58	20	adenosine	adenosine	NOUN
ajbspi-134509	58	21	[	[	X
ajbspi-134509	58	22	8	8	NUM
ajbspi-134509	58	23	,	,	PUNCT
ajbspi-134509	58	24	21	21	NUM
ajbspi-134509	58	25	,	,	PUNCT
ajbspi-134509	58	26	31	31	NUM
ajbspi-134509	58	27	,	,	PUNCT
ajbspi-134509	58	28	32	32	NUM
ajbspi-134509	58	29	,	,	PUNCT
ajbspi-134509	58	30	48	48	NUM
ajbspi-134509	58	31	]	]	PUNCT
ajbspi-134509	58	32	.	.	PUNCT
ajbspi-134509	59	1	cd73	cd73	PROPN
ajbspi-134509	59	2	is	be	AUX
ajbspi-134509	59	3	also	also	ADV
ajbspi-134509	59	4	broadly	broadly	ADV
ajbspi-134509	59	5	expressed	express	VERB
ajbspi-134509	59	6	on	on	ADP
ajbspi-134509	59	7	diverse	diverse	ADJ
ajbspi-134509	59	8	cell	cell	NOUN
ajbspi-134509	59	9	types	type	NOUN
ajbspi-134509	59	10	,	,	PUNCT
ajbspi-134509	59	11	including	include	VERB
ajbspi-134509	59	12	epithelial	epithelial	ADJ
ajbspi-134509	59	13	cells	cell	NOUN
ajbspi-134509	59	14	,	,	PUNCT
ajbspi-134509	59	15	fibroblasts	fibroblast	NOUN
ajbspi-134509	59	16	,	,	PUNCT
ajbspi-134509	59	17	and	and	CCONJ
ajbspi-134509	59	18	various	various	ADJ
ajbspi-134509	59	19	immune	immune	ADJ
ajbspi-134509	59	20	cells	cell	NOUN
ajbspi-134509	59	21	[	[	X
ajbspi-134509	59	22	8	8	NUM
ajbspi-134509	59	23	,	,	PUNCT
ajbspi-134509	59	24	21	21	NUM
ajbspi-134509	59	25	,	,	PUNCT
ajbspi-134509	59	26	31	31	NUM
ajbspi-134509	59	27	,	,	PUNCT
ajbspi-134509	59	28	32	32	NUM
ajbspi-134509	59	29	]	]	PUNCT
ajbspi-134509	59	30	.	.	PUNCT
ajbspi-134509	60	1	the	the	DET
ajbspi-134509	60	2	combined	combined	ADJ
ajbspi-134509	60	3	action	action	NOUN
ajbspi-134509	60	4	of	of	ADP
ajbspi-134509	60	5	cd39	cd39	PROPN
ajbspi-134509	60	6	and	and	CCONJ
ajbspi-134509	60	7	cd73	cd73	PROPN
ajbspi-134509	60	8	effectively	effectively	ADV
ajbspi-134509	60	9	converts	convert	VERB
ajbspi-134509	60	10	pro	pro	ADJ
ajbspi-134509	60	11	-	-	ADJ
ajbspi-134509	60	12	inflammatory	inflammatory	ADJ
ajbspi-134509	60	13	atp	atp	NOUN
ajbspi-134509	60	14	signals	signal	NOUN
ajbspi-134509	60	15	into	into	ADP
ajbspi-134509	60	16	anti	anti	ADJ
ajbspi-134509	60	17	-	-	ADJ
ajbspi-134509	60	18	inflammatory	inflammatory	ADJ
ajbspi-134509	60	19	adenosine	adenosine	NOUN
ajbspi-134509	60	20	signals	signal	NOUN
ajbspi-134509	60	21	,	,	PUNCT
ajbspi-134509	60	22	thereby	thereby	ADV
ajbspi-134509	60	23	shaping	shape	VERB
ajbspi-134509	60	24	the	the	DET
ajbspi-134509	60	25	local	local	ADJ
ajbspi-134509	60	26	immune	immune	ADJ
ajbspi-134509	60	27	microenvironment	microenvironment	NOUN
ajbspi-134509	60	28	[	[	X
ajbspi-134509	60	29	21	21	NUM
ajbspi-134509	60	30	,	,	PUNCT
ajbspi-134509	60	31	31	31	NUM
ajbspi-134509	60	32	,	,	PUNCT
ajbspi-134509	60	33	32	32	NUM
ajbspi-134509	60	34	,	,	PUNCT
ajbspi-134509	60	35	35	35	NUM
ajbspi-134509	60	36	]	]	PUNCT
ajbspi-134509	60	37	.	.	PUNCT
ajbspi-134509	61	1	this	this	DET
ajbspi-134509	61	2	enzymatic	enzymatic	ADJ
ajbspi-134509	61	3	cascade	cascade	NOUN
ajbspi-134509	61	4	is	be	AUX
ajbspi-134509	61	5	critical	critical	ADJ
ajbspi-134509	61	6	for	for	ADP
ajbspi-134509	61	7	maintaining	maintain	VERB
ajbspi-134509	61	8	purinergic	purinergic	NOUN
ajbspi-134509	61	9	balance	balance	NOUN
ajbspi-134509	61	10	and	and	CCONJ
ajbspi-134509	61	11	modulating	modulate	VERB
ajbspi-134509	61	12	immune	immune	ADJ
ajbspi-134509	61	13	responses	response	NOUN
ajbspi-134509	61	14	[	[	X
ajbspi-134509	61	15	6	6	NUM
ajbspi-134509	61	16	]	]	PUNCT
ajbspi-134509	61	17	.	.	PUNCT
ajbspi-134509	62	1	beyond	beyond	ADP
ajbspi-134509	62	2	this	this	DET
ajbspi-134509	62	3	primary	primary	ADJ
ajbspi-134509	62	4	pathway	pathway	NOUN
ajbspi-134509	62	5	,	,	PUNCT
ajbspi-134509	62	6	other	other	ADJ
ajbspi-134509	62	7	enzymes	enzyme	NOUN
ajbspi-134509	62	8	like	like	ADP
ajbspi-134509	62	9	nonspecific	nonspecific	ADJ
ajbspi-134509	62	10	alkaline	alkaline	NOUN
ajbspi-134509	62	11	phosphatase	phosphatase	NOUN
ajbspi-134509	62	12	can	can	AUX
ajbspi-134509	62	13	also	also	ADV
ajbspi-134509	62	14	hydrolyze	hydrolyze	VERB
ajbspi-134509	62	15	amp	amp	NOUN
ajbspi-134509	62	16	to	to	PART
ajbspi-134509	62	17	adenosine	adenosine	VERB
ajbspi-134509	62	18	,	,	PUNCT
ajbspi-134509	62	19	contributing	contribute	VERB
ajbspi-134509	62	20	to	to	ADP
ajbspi-134509	62	21	the	the	DET
ajbspi-134509	62	22	overall	overall	ADJ
ajbspi-134509	62	23	extracellular	extracellular	ADJ
ajbspi-134509	62	24	adenosine	adenosine	NOUN
ajbspi-134509	62	25	pool	pool	NOUN
ajbspi-134509	62	26	[	[	X
ajbspi-134509	62	27	8	8	NUM
ajbspi-134509	62	28	]	]	PUNCT
ajbspi-134509	62	29	.	.	PUNCT
ajbspi-134509	63	1	adenosine	adenosine	NOUN
ajbspi-134509	63	2	receptors	receptor	NOUN
ajbspi-134509	63	3	once	once	ADV
ajbspi-134509	63	4	generated	generate	VERB
ajbspi-134509	63	5	,	,	PUNCT
ajbspi-134509	63	6	extracellular	extracellular	ADJ
ajbspi-134509	63	7	adenosine	adenosine	NOUN
ajbspi-134509	63	8	exerts	exert	VERB
ajbspi-134509	63	9	its	its	PRON
ajbspi-134509	63	10	biological	biological	ADJ
ajbspi-134509	63	11	effects	effect	NOUN
ajbspi-134509	63	12	by	by	ADP
ajbspi-134509	63	13	binding	bind	VERB
ajbspi-134509	63	14	to	to	ADP
ajbspi-134509	63	15	and	and	CCONJ
ajbspi-134509	63	16	activating	activate	VERB
ajbspi-134509	63	17	specific	specific	ADJ
ajbspi-134509	63	18	g	g	NOUN
ajbspi-134509	63	19	protein	protein	NOUN
ajbspi-134509	63	20	-	-	PUNCT
ajbspi-134509	63	21	coupled	couple	VERB
ajbspi-134509	63	22	receptors	receptor	NOUN
ajbspi-134509	63	23	(	(	PUNCT
ajbspi-134509	63	24	gpcrs	gpcrs	PROPN
ajbspi-134509	63	25	)	)	PUNCT
ajbspi-134509	63	26	located	locate	VERB
ajbspi-134509	63	27	on	on	ADP
ajbspi-134509	63	28	the	the	DET
ajbspi-134509	63	29	cell	cell	NOUN
ajbspi-134509	63	30	surface	surface	NOUN
ajbspi-134509	63	31	.	.	PUNCT
ajbspi-134509	64	1	there	there	PRON
ajbspi-134509	64	2	are	be	VERB
ajbspi-134509	64	3	four	four	NUM
ajbspi-134509	64	4	known	know	VERB
ajbspi-134509	64	5	adenosine	adenosine	NOUN
ajbspi-134509	64	6	receptor	receptor	NOUN
ajbspi-134509	64	7	subtypes	subtype	NOUN
ajbspi-134509	64	8	,	,	PUNCT
ajbspi-134509	64	9	each	each	PRON
ajbspi-134509	64	10	with	with	ADP
ajbspi-134509	64	11	distinct	distinct	ADJ
ajbspi-134509	64	12	pharmacological	pharmacological	ADJ
ajbspi-134509	64	13	profiles	profile	NOUN
ajbspi-134509	64	14	,	,	PUNCT
ajbspi-134509	64	15	tissue	tissue	NOUN
ajbspi-134509	64	16	distribution	distribution	NOUN
ajbspi-134509	64	17	,	,	PUNCT
ajbspi-134509	64	18	and	and	CCONJ
ajbspi-134509	64	19	downstream	downstream	ADJ
ajbspi-134509	64	20	signaling	signal	VERB
ajbspi-134509	64	21	pathways	pathway	NOUN
ajbspi-134509	65	1	[	[	X
ajbspi-134509	65	2	3	3	NUM
ajbspi-134509	65	3	,	,	PUNCT
ajbspi-134509	65	4	10	10	NUM
ajbspi-134509	65	5	,	,	PUNCT
ajbspi-134509	65	6	11	11	NUM
ajbspi-134509	65	7	,	,	PUNCT
ajbspi-134509	65	8	12	12	NUM
ajbspi-134509	65	9	]	]	SYM
ajbspi-134509	65	10	:	:	PUNCT
ajbspi-134509	65	11	•	•	NUM
ajbspi-134509	65	12	a1	a1	NOUN
ajbspi-134509	65	13	adenosine	adenosine	NOUN
ajbspi-134509	65	14	receptor	receptor	NOUN
ajbspi-134509	65	15	(	(	PUNCT
ajbspi-134509	65	16	a1ar	a1ar	NUM
ajbspi-134509	65	17	):	):	PUNCT
ajbspi-134509	65	18	primarily	primarily	ADV
ajbspi-134509	65	19	coupled	couple	VERB
ajbspi-134509	65	20	to	to	PART
ajbspi-134509	65	21	gi	gi	VERB
ajbspi-134509	65	22	/	/	SYM
ajbspi-134509	65	23	o	o	NOUN
ajbspi-134509	65	24	proteins	protein	NOUN
ajbspi-134509	65	25	,	,	PUNCT
ajbspi-134509	65	26	leading	lead	VERB
ajbspi-134509	65	27	to	to	ADP
ajbspi-134509	65	28	inhibition	inhibition	NOUN
ajbspi-134509	65	29	of	of	ADP
ajbspi-134509	65	30	adenylyl	adenylyl	ADJ
ajbspi-134509	65	31	cyclase	cyclase	NOUN
ajbspi-134509	65	32	and	and	CCONJ
ajbspi-134509	65	33	a	a	DET
ajbspi-134509	65	34	decrease	decrease	NOUN
ajbspi-134509	65	35	in	in	ADP
ajbspi-134509	65	36	intracellular	intracellular	ADJ
ajbspi-134509	65	37	camp	camp	NOUN
ajbspi-134509	65	38	.	.	PUNCT
ajbspi-134509	66	1	a1ars	a1ar	NOUN
ajbspi-134509	66	2	are	be	AUX
ajbspi-134509	66	3	involved	involve	VERB
ajbspi-134509	66	4	in	in	ADP
ajbspi-134509	66	5	various	various	ADJ
ajbspi-134509	66	6	physiological	physiological	ADJ
ajbspi-134509	66	7	processes	process	NOUN
ajbspi-134509	66	8	,	,	PUNCT
ajbspi-134509	66	9	including	include	VERB
ajbspi-134509	66	10	cardiac	cardiac	ADJ
ajbspi-134509	66	11	function	function	NOUN
ajbspi-134509	66	12	,	,	PUNCT
ajbspi-134509	66	13	neuronal	neuronal	ADJ
ajbspi-134509	66	14	activity	activity	NOUN
ajbspi-134509	66	15	,	,	PUNCT
ajbspi-134509	66	16	and	and	CCONJ
ajbspi-134509	66	17	pain	pain	NOUN
ajbspi-134509	66	18	modulation	modulation	NOUN
ajbspi-134509	66	19	[	[	X
ajbspi-134509	66	20	3	3	NUM
ajbspi-134509	66	21	,	,	PUNCT
ajbspi-134509	66	22	12	12	NUM
ajbspi-134509	66	23	]	]	PUNCT
ajbspi-134509	66	24	.	.	PUNCT
ajbspi-134509	67	1	•	•	NUM
ajbspi-134509	67	2	a2a	a2a	PROPN
ajbspi-134509	67	3	adenosine	adenosine	NOUN
ajbspi-134509	67	4	receptor	receptor	NOUN
ajbspi-134509	67	5	(	(	PUNCT
ajbspi-134509	67	6	a2aar	a2aar	PRON
ajbspi-134509	67	7	):	):	PUNCT
ajbspi-134509	67	8	coupled	couple	VERB
ajbspi-134509	67	9	to	to	ADP
ajbspi-134509	67	10	gs	gs	PROPN
ajbspi-134509	67	11	proteins	protein	NOUN
ajbspi-134509	67	12	,	,	PUNCT
ajbspi-134509	67	13	leading	lead	VERB
ajbspi-134509	67	14	to	to	ADP
ajbspi-134509	67	15	activation	activation	NOUN
ajbspi-134509	67	16	of	of	ADP
ajbspi-134509	67	17	adenylyl	adenylyl	ADJ
ajbspi-134509	67	18	cyclase	cyclase	NOUN
ajbspi-134509	67	19	and	and	CCONJ
ajbspi-134509	67	20	an	an	DET
ajbspi-134509	67	21	increase	increase	NOUN
ajbspi-134509	67	22	in	in	ADP
ajbspi-134509	67	23	intracellular	intracellular	ADJ
ajbspi-134509	67	24	camp	camp	NOUN
ajbspi-134509	67	25	.	.	PUNCT
ajbspi-134509	68	1	a2aars	a2aar	NOUN
ajbspi-134509	68	2	are	be	AUX
ajbspi-134509	68	3	highly	highly	ADV
ajbspi-134509	68	4	expressed	express	VERB
ajbspi-134509	68	5	on	on	ADP
ajbspi-134509	68	6	immune	immune	ADJ
ajbspi-134509	68	7	cells	cell	NOUN
ajbspi-134509	68	8	and	and	CCONJ
ajbspi-134509	68	9	play	play	VERB
ajbspi-134509	68	10	a	a	DET
ajbspi-134509	68	11	predominant	predominant	ADJ
ajbspi-134509	68	12	role	role	NOUN
ajbspi-134509	68	13	in	in	ADP
ajbspi-134509	68	14	mediating	mediate	VERB
ajbspi-134509	68	15	the	the	DET
ajbspi-134509	68	16	anti	anti	ADJ
ajbspi-134509	68	17	-	-	ADJ
ajbspi-134509	68	18	inflammatory	inflammatory	ADJ
ajbspi-134509	68	19	and	and	CCONJ
ajbspi-134509	68	20	immunosuppressive	immunosuppressive	ADJ
ajbspi-134509	68	21	effects	effect	NOUN
ajbspi-134509	68	22	of	of	ADP
ajbspi-134509	68	23	adenosine	adenosine	NOUN
ajbspi-134509	68	24	[	[	X
ajbspi-134509	68	25	3	3	NUM
ajbspi-134509	68	26	,	,	PUNCT
ajbspi-134509	68	27	10	10	NUM
ajbspi-134509	68	28	,	,	PUNCT
ajbspi-134509	68	29	12	12	NUM
ajbspi-134509	68	30	]	]	PUNCT
ajbspi-134509	68	31	.	.	PUNCT
ajbspi-134509	69	1	•	•	NUM
ajbspi-134509	69	2	a2b	a2b	NOUN
ajbspi-134509	69	3	adenosine	adenosine	ADJ
ajbspi-134509	69	4	receptor	receptor	NOUN
ajbspi-134509	69	5	(	(	PUNCT
ajbspi-134509	69	6	a2bar	a2bar	NOUN
ajbspi-134509	69	7	):	):	PUNCT
ajbspi-134509	69	8	also	also	ADV
ajbspi-134509	69	9	coupled	couple	VERB
ajbspi-134509	69	10	to	to	ADP
ajbspi-134509	69	11	gs	gs	PROPN
ajbspi-134509	69	12	proteins	protein	NOUN
ajbspi-134509	69	13	and	and	CCONJ
ajbspi-134509	69	14	increases	increase	VERB
ajbspi-134509	69	15	camp	camp	NOUN
ajbspi-134509	69	16	.	.	PUNCT
ajbspi-134509	70	1	a2bars	a2bar	NOUN
ajbspi-134509	70	2	have	have	VERB
ajbspi-134509	70	3	a	a	DET
ajbspi-134509	70	4	lower	low	ADJ
ajbspi-134509	70	5	affinity	affinity	NOUN
ajbspi-134509	70	6	for	for	ADP
ajbspi-134509	70	7	adenosine	adenosine	NOUN
ajbspi-134509	70	8	compared	compare	VERB
ajbspi-134509	70	9	to	to	ADP
ajbspi-134509	70	10	a2aars	a2aar	NOUN
ajbspi-134509	70	11	,	,	PUNCT
ajbspi-134509	70	12	meaning	mean	VERB
ajbspi-134509	70	13	they	they	PRON
ajbspi-134509	70	14	are	be	AUX
ajbspi-134509	70	15	typically	typically	ADV
ajbspi-134509	70	16	activated	activate	VERB
ajbspi-134509	70	17	when	when	SCONJ
ajbspi-134509	70	18	adenosine	adenosine	ADJ
ajbspi-134509	70	19	concentrations	concentration	NOUN
ajbspi-134509	70	20	are	be	AUX
ajbspi-134509	70	21	higher	high	ADJ
ajbspi-134509	70	22	,	,	PUNCT
ajbspi-134509	70	23	such	such	ADJ
ajbspi-134509	70	24	as	as	ADP
ajbspi-134509	70	25	during	during	ADP
ajbspi-134509	70	26	severe	severe	ADJ
ajbspi-134509	70	27	inflammation	inflammation	NOUN
ajbspi-134509	70	28	or	or	CCONJ
ajbspi-134509	70	29	tissue	tissue	NOUN
ajbspi-134509	70	30	damage	damage	NOUN
ajbspi-134509	70	31	[	[	X
ajbspi-134509	70	32	10	10	NUM
ajbspi-134509	70	33	,	,	PUNCT
ajbspi-134509	70	34	12	12	NUM
ajbspi-134509	70	35	]	]	PUNCT
ajbspi-134509	70	36	.	.	PUNCT
ajbspi-134509	71	1	they	they	PRON
ajbspi-134509	71	2	are	be	AUX
ajbspi-134509	71	3	involved	involve	VERB
ajbspi-134509	71	4	in	in	ADP
ajbspi-134509	71	5	mast	mast	NOUN
ajbspi-134509	71	6	cell	cell	NOUN
ajbspi-134509	71	7	degranulation	degranulation	NOUN
ajbspi-134509	71	8	,	,	PUNCT
ajbspi-134509	71	9	angiogenesis	angiogenesis	NOUN
ajbspi-134509	71	10	,	,	PUNCT
ajbspi-134509	71	11	and	and	CCONJ
ajbspi-134509	71	12	cytokine	cytokine	VERB
ajbspi-134509	71	13	production	production	NOUN
ajbspi-134509	71	14	[	[	X
ajbspi-134509	71	15	10	10	NUM
ajbspi-134509	71	16	,	,	PUNCT
ajbspi-134509	71	17	33	33	NUM
ajbspi-134509	71	18	]	]	PUNCT
ajbspi-134509	71	19	.	.	PUNCT
ajbspi-134509	72	1	•	•	NUM
ajbspi-134509	72	2	a3	a3	NOUN
ajbspi-134509	72	3	adenosine	adenosine	NOUN
ajbspi-134509	72	4	receptor	receptor	NOUN
ajbspi-134509	72	5	(	(	PUNCT
ajbspi-134509	72	6	a3ar	a3ar	ADJ
ajbspi-134509	72	7	):	):	PUNCT
ajbspi-134509	72	8	primarily	primarily	ADV
ajbspi-134509	72	9	coupled	couple	VERB
ajbspi-134509	72	10	to	to	PART
ajbspi-134509	72	11	gi	gi	VERB
ajbspi-134509	72	12	/	/	SYM
ajbspi-134509	72	13	o	o	NOUN
ajbspi-134509	72	14	proteins	protein	NOUN
ajbspi-134509	72	15	,	,	PUNCT
ajbspi-134509	72	16	similar	similar	ADJ
ajbspi-134509	72	17	to	to	ADP
ajbspi-134509	72	18	a1ar	a1ar	PROPN
ajbspi-134509	72	19	,	,	PUNCT
ajbspi-134509	72	20	inhibiting	inhibit	VERB
ajbspi-134509	72	21	camp	camp	NOUN
ajbspi-134509	72	22	production	production	NOUN
ajbspi-134509	72	23	.	.	PUNCT
ajbspi-134509	73	1	a3ars	a3ar	NOUN
ajbspi-134509	73	2	are	be	AUX
ajbspi-134509	73	3	involved	involve	VERB
ajbspi-134509	73	4	in	in	ADP
ajbspi-134509	73	5	mast	mast	NOUN
ajbspi-134509	73	6	cell	cell	NOUN
ajbspi-134509	73	7	degranulation	degranulation	NOUN
ajbspi-134509	73	8	,	,	PUNCT
ajbspi-134509	73	9	cardioprotection	cardioprotection	NOUN
ajbspi-134509	73	10	,	,	PUNCT
ajbspi-134509	73	11	and	and	CCONJ
ajbspi-134509	73	12	some	some	DET
ajbspi-134509	73	13	proinflammatory	proinflammatory	ADJ
ajbspi-134509	73	14	responses	response	NOUN
ajbspi-134509	73	15	,	,	PUNCT
ajbspi-134509	73	16	depending	depend	VERB
ajbspi-134509	73	17	on	on	ADP
ajbspi-134509	73	18	the	the	DET
ajbspi-134509	73	19	context	context	NOUN
ajbspi-134509	74	1	[	[	X
ajbspi-134509	74	2	3	3	NUM
ajbspi-134509	74	3	,	,	PUNCT
ajbspi-134509	74	4	12	12	NUM
ajbspi-134509	74	5	]	]	PUNCT
ajbspi-134509	74	6	.	.	PUNCT
ajbspi-134509	75	1	the	the	DET
ajbspi-134509	75	2	specific	specific	ADJ
ajbspi-134509	75	3	effects	effect	NOUN
ajbspi-134509	75	4	of	of	ADP
ajbspi-134509	75	5	adenosine	adenosine	NOUN
ajbspi-134509	75	6	are	be	AUX
ajbspi-134509	75	7	highly	highly	ADV
ajbspi-134509	75	8	dependent	dependent	ADJ
ajbspi-134509	75	9	on	on	ADP
ajbspi-134509	75	10	the	the	DET
ajbspi-134509	75	11	local	local	ADJ
ajbspi-134509	75	12	concentration	concentration	NOUN
ajbspi-134509	75	13	of	of	ADP
ajbspi-134509	75	14	adenosine	adenosine	NOUN
ajbspi-134509	75	15	,	,	PUNCT
ajbspi-134509	75	16	the	the	DET
ajbspi-134509	75	17	expression	expression	NOUN
ajbspi-134509	75	18	profile	profile	NOUN
ajbspi-134509	75	19	of	of	ADP
ajbspi-134509	75	20	adenosine	adenosine	ADJ
ajbspi-134509	75	21	receptors	receptor	NOUN
ajbspi-134509	75	22	on	on	ADP
ajbspi-134509	75	23	target	target	NOUN
ajbspi-134509	75	24	cells	cell	NOUN
ajbspi-134509	75	25	,	,	PUNCT
ajbspi-134509	75	26	and	and	CCONJ
ajbspi-134509	75	27	the	the	DET
ajbspi-134509	75	28	cellular	cellular	ADJ
ajbspi-134509	75	29	context	context	NOUN
ajbspi-134509	75	30	[	[	X
ajbspi-134509	75	31	3	3	NUM
ajbspi-134509	75	32	,	,	PUNCT
ajbspi-134509	75	33	12	12	NUM
ajbspi-134509	75	34	]	]	PUNCT
ajbspi-134509	75	35	.	.	PUNCT
ajbspi-134509	76	1	adenosine	adenosine	NOUN
ajbspi-134509	76	2	transport	transport	NOUN
ajbspi-134509	76	3	the	the	DET
ajbspi-134509	76	4	concentration	concentration	NOUN
ajbspi-134509	76	5	of	of	ADP
ajbspi-134509	76	6	extracellular	extracellular	ADJ
ajbspi-134509	76	7	adenosine	adenosine	NOUN
ajbspi-134509	76	8	is	be	AUX
ajbspi-134509	76	9	also	also	ADV
ajbspi-134509	76	10	regulated	regulate	VERB
ajbspi-134509	76	11	by	by	ADP
ajbspi-134509	76	12	nucleoside	nucleoside	ADJ
ajbspi-134509	76	13	transporters	transporter	NOUN
ajbspi-134509	76	14	,	,	PUNCT
ajbspi-134509	76	15	which	which	PRON
ajbspi-134509	76	16	facilitate	facilitate	VERB
ajbspi-134509	76	17	american	american	ADJ
ajbspi-134509	76	18	journal	journal	PROPN
ajbspi-134509	76	19	of	of	ADP
ajbspi-134509	76	20	applied	apply	VERB
ajbspi-134509	76	21	science	science	NOUN
ajbspi-134509	76	22	and	and	CCONJ
ajbspi-134509	76	23	technology	technology	NOUN
ajbspi-134509	76	24	4	4	NUM
ajbspi-134509	76	25	https://theusajournals.com/index.php/ajast	https://theusajournals.com/index.php/ajast	VERB
ajbspi-134509	76	26	american	american	PROPN
ajbspi-134509	76	27	journal	journal	PROPN
ajbspi-134509	76	28	of	of	ADP
ajbspi-134509	76	29	applied	apply	VERB
ajbspi-134509	76	30	science	science	NOUN
ajbspi-134509	76	31	and	and	CCONJ
ajbspi-134509	76	32	technology	technology	NOUN
ajbspi-134509	76	33	(	(	PUNCT
ajbspi-134509	76	34	issn	issn	PROPN
ajbspi-134509	76	35	:	:	PUNCT
ajbspi-134509	76	36	2771	2771	NUM
ajbspi-134509	76	37	-	-	SYM
ajbspi-134509	76	38	2745	2745	NUM
ajbspi-134509	76	39	)	)	PUNCT
ajbspi-134509	76	40	the	the	DET
ajbspi-134509	76	41	uptake	uptake	NOUN
ajbspi-134509	76	42	of	of	ADP
ajbspi-134509	76	43	adenosine	adenosine	NOUN
ajbspi-134509	76	44	into	into	ADP
ajbspi-134509	76	45	cells	cell	NOUN
ajbspi-134509	76	46	.	.	PUNCT
ajbspi-134509	77	1	these	these	DET
ajbspi-134509	77	2	transporters	transporter	NOUN
ajbspi-134509	77	3	belong	belong	VERB
ajbspi-134509	77	4	to	to	ADP
ajbspi-134509	77	5	two	two	NUM
ajbspi-134509	77	6	main	main	ADJ
ajbspi-134509	77	7	families	family	NOUN
ajbspi-134509	77	8	:	:	PUNCT
ajbspi-134509	77	9	concentrative	concentrative	ADJ
ajbspi-134509	77	10	nucleoside	nucleoside	ADJ
ajbspi-134509	77	11	transporters	transporter	NOUN
ajbspi-134509	77	12	(	(	PUNCT
ajbspi-134509	77	13	cnts	cnt	NOUN
ajbspi-134509	77	14	,	,	PUNCT
ajbspi-134509	77	15	slc28	slc28	NOUN
ajbspi-134509	77	16	family	family	NOUN
ajbspi-134509	77	17	)	)	PUNCT
ajbspi-134509	77	18	and	and	CCONJ
ajbspi-134509	77	19	equilibrative	equilibrative	ADJ
ajbspi-134509	77	20	nucleoside	nucleoside	NOUN
ajbspi-134509	77	21	transporters	transporter	NOUN
ajbspi-134509	77	22	(	(	PUNCT
ajbspi-134509	77	23	ents	ent	NOUN
ajbspi-134509	77	24	,	,	PUNCT
ajbspi-134509	77	25	slc29	slc29	ADJ
ajbspi-134509	77	26	family	family	NOUN
ajbspi-134509	77	27	)	)	PUNCT
ajbspi-134509	78	1	[	[	X
ajbspi-134509	78	2	9	9	NUM
ajbspi-134509	78	3	]	]	PUNCT
ajbspi-134509	78	4	.	.	PUNCT
ajbspi-134509	79	1	these	these	DET
ajbspi-134509	79	2	transporters	transporter	NOUN
ajbspi-134509	79	3	play	play	VERB
ajbspi-134509	79	4	a	a	DET
ajbspi-134509	79	5	crucial	crucial	ADJ
ajbspi-134509	79	6	role	role	NOUN
ajbspi-134509	79	7	in	in	ADP
ajbspi-134509	79	8	terminating	terminate	VERB
ajbspi-134509	79	9	adenosine	adenosine	NOUN
ajbspi-134509	79	10	signaling	signal	VERB
ajbspi-134509	79	11	by	by	ADP
ajbspi-134509	79	12	removing	remove	VERB
ajbspi-134509	79	13	it	it	PRON
ajbspi-134509	79	14	from	from	ADP
ajbspi-134509	79	15	the	the	DET
ajbspi-134509	79	16	extracellular	extracellular	ADJ
ajbspi-134509	79	17	space	space	NOUN
ajbspi-134509	79	18	and	and	CCONJ
ajbspi-134509	79	19	in	in	ADP
ajbspi-134509	79	20	recycling	recycle	VERB
ajbspi-134509	79	21	purines	purine	NOUN
ajbspi-134509	79	22	for	for	ADP
ajbspi-134509	79	23	nucleotide	nucleotide	ADJ
ajbspi-134509	79	24	synthesis	synthesis	NOUN
ajbspi-134509	79	25	[	[	X
ajbspi-134509	79	26	9	9	NUM
ajbspi-134509	79	27	]	]	PUNCT
ajbspi-134509	79	28	.	.	PUNCT
ajbspi-134509	80	1	adenosine	adenosine	PROPN
ajbspi-134509	80	2	's	's	PART
ajbspi-134509	80	3	immunomodulatory	immunomodulatory	ADJ
ajbspi-134509	80	4	roles	role	NOUN
ajbspi-134509	80	5	adenosine	adenosine	VERB
ajbspi-134509	80	6	is	be	AUX
ajbspi-134509	80	7	a	a	DET
ajbspi-134509	80	8	powerful	powerful	ADJ
ajbspi-134509	80	9	immunomodulator	immunomodulator	NOUN
ajbspi-134509	80	10	,	,	PUNCT
ajbspi-134509	80	11	generally	generally	ADV
ajbspi-134509	80	12	acting	act	VERB
ajbspi-134509	80	13	to	to	PART
ajbspi-134509	80	14	dampen	dampen	VERB
ajbspi-134509	80	15	excessive	excessive	ADJ
ajbspi-134509	80	16	inflammation	inflammation	NOUN
ajbspi-134509	80	17	and	and	CCONJ
ajbspi-134509	80	18	promote	promote	VERB
ajbspi-134509	80	19	resolution	resolution	NOUN
ajbspi-134509	80	20	,	,	PUNCT
ajbspi-134509	80	21	particularly	particularly	ADV
ajbspi-134509	80	22	at	at	ADP
ajbspi-134509	80	23	sites	site	NOUN
ajbspi-134509	80	24	of	of	ADP
ajbspi-134509	80	25	tissue	tissue	NOUN
ajbspi-134509	80	26	injury	injury	NOUN
ajbspi-134509	80	27	or	or	CCONJ
ajbspi-134509	80	28	infection	infection	NOUN
ajbspi-134509	80	29	[	[	X
ajbspi-134509	80	30	13	13	NUM
ajbspi-134509	80	31	,	,	PUNCT
ajbspi-134509	80	32	16	16	NUM
ajbspi-134509	80	33	]	]	PUNCT
ajbspi-134509	80	34	.	.	PUNCT
ajbspi-134509	81	1	this	this	DET
ajbspi-134509	81	2	protective	protective	ADJ
ajbspi-134509	81	3	role	role	NOUN
ajbspi-134509	81	4	is	be	AUX
ajbspi-134509	81	5	crucial	crucial	ADJ
ajbspi-134509	81	6	for	for	ADP
ajbspi-134509	81	7	preventing	prevent	VERB
ajbspi-134509	81	8	collateral	collateral	ADJ
ajbspi-134509	81	9	damage	damage	NOUN
ajbspi-134509	81	10	from	from	ADP
ajbspi-134509	81	11	an	an	DET
ajbspi-134509	81	12	overzealous	overzealous	ADJ
ajbspi-134509	81	13	immune	immune	ADJ
ajbspi-134509	81	14	response	response	NOUN
ajbspi-134509	81	15	.	.	PUNCT
ajbspi-134509	82	1	however	however	ADV
ajbspi-134509	82	2	,	,	PUNCT
ajbspi-134509	82	3	this	this	DET
ajbspi-134509	82	4	very	very	ADJ
ajbspi-134509	82	5	mechanism	mechanism	NOUN
ajbspi-134509	82	6	can	can	AUX
ajbspi-134509	82	7	be	be	AUX
ajbspi-134509	82	8	exploited	exploit	VERB
ajbspi-134509	82	9	by	by	ADP
ajbspi-134509	82	10	pathogens	pathogen	NOUN
ajbspi-134509	82	11	to	to	PART
ajbspi-134509	82	12	evade	evade	VERB
ajbspi-134509	82	13	host	host	NOUN
ajbspi-134509	82	14	immunity	immunity	NOUN
ajbspi-134509	82	15	.	.	PUNCT
ajbspi-134509	83	1	general	general	ADJ
ajbspi-134509	83	2	immunosuppressive	immunosuppressive	ADJ
ajbspi-134509	83	3	nature	nature	NOUN
ajbspi-134509	83	4	at	at	ADP
ajbspi-134509	83	5	sites	site	NOUN
ajbspi-134509	83	6	of	of	ADP
ajbspi-134509	83	7	inflammation	inflammation	NOUN
ajbspi-134509	83	8	,	,	PUNCT
ajbspi-134509	83	9	the	the	DET
ajbspi-134509	83	10	increased	increase	VERB
ajbspi-134509	83	11	release	release	NOUN
ajbspi-134509	83	12	of	of	ADP
ajbspi-134509	83	13	atp	atp	PROPN
ajbspi-134509	83	14	from	from	ADP
ajbspi-134509	83	15	stressed	stress	VERB
ajbspi-134509	83	16	or	or	CCONJ
ajbspi-134509	83	17	dying	die	VERB
ajbspi-134509	83	18	cells	cell	NOUN
ajbspi-134509	83	19	leads	lead	VERB
ajbspi-134509	83	20	to	to	ADP
ajbspi-134509	83	21	a	a	DET
ajbspi-134509	83	22	surge	surge	NOUN
ajbspi-134509	83	23	in	in	ADP
ajbspi-134509	83	24	extracellular	extracellular	ADJ
ajbspi-134509	83	25	atp	atp	NOUN
ajbspi-134509	83	26	.	.	PUNCT
ajbspi-134509	84	1	this	this	DET
ajbspi-134509	84	2	pro	pro	ADJ
ajbspi-134509	84	3	-	-	ADJ
ajbspi-134509	84	4	inflammatory	inflammatory	ADJ
ajbspi-134509	84	5	signal	signal	NOUN
ajbspi-134509	84	6	is	be	AUX
ajbspi-134509	84	7	then	then	ADV
ajbspi-134509	84	8	rapidly	rapidly	ADV
ajbspi-134509	84	9	converted	convert	VERB
ajbspi-134509	84	10	to	to	PART
ajbspi-134509	84	11	adenosine	adenosine	VERB
ajbspi-134509	84	12	by	by	ADP
ajbspi-134509	84	13	cd39	cd39	PROPN
ajbspi-134509	84	14	and	and	CCONJ
ajbspi-134509	84	15	cd73	cd73	PROPN
ajbspi-134509	84	16	[	[	X
ajbspi-134509	84	17	13	13	NUM
ajbspi-134509	84	18	,	,	PUNCT
ajbspi-134509	84	19	16	16	NUM
ajbspi-134509	84	20	,	,	PUNCT
ajbspi-134509	84	21	35	35	NUM
ajbspi-134509	84	22	]	]	PUNCT
ajbspi-134509	84	23	.	.	PUNCT
ajbspi-134509	85	1	the	the	DET
ajbspi-134509	85	2	resulting	result	VERB
ajbspi-134509	85	3	high	high	ADJ
ajbspi-134509	85	4	local	local	ADJ
ajbspi-134509	85	5	concentrations	concentration	NOUN
ajbspi-134509	85	6	of	of	ADP
ajbspi-134509	85	7	adenosine	adenosine	NOUN
ajbspi-134509	85	8	activate	activate	VERB
ajbspi-134509	85	9	adenosine	adenosine	NOUN
ajbspi-134509	85	10	receptors	receptor	NOUN
ajbspi-134509	85	11	,	,	PUNCT
ajbspi-134509	85	12	primarily	primarily	ADV
ajbspi-134509	85	13	a2aar	a2aar	PRON
ajbspi-134509	85	14	and	and	CCONJ
ajbspi-134509	85	15	a2bar	a2bar	NOUN
ajbspi-134509	85	16	,	,	PUNCT
ajbspi-134509	85	17	leading	lead	VERB
ajbspi-134509	85	18	to	to	ADP
ajbspi-134509	85	19	a	a	DET
ajbspi-134509	85	20	shift	shift	NOUN
ajbspi-134509	85	21	towards	towards	ADP
ajbspi-134509	85	22	an	an	DET
ajbspi-134509	85	23	antiinflammatory	antiinflammatory	NOUN
ajbspi-134509	85	24	and	and	CCONJ
ajbspi-134509	85	25	immunosuppressive	immunosuppressive	ADJ
ajbspi-134509	85	26	phenotype	phenotype	NOUN
ajbspi-134509	85	27	[	[	X
ajbspi-134509	85	28	13	13	NUM
ajbspi-134509	85	29	,	,	PUNCT
ajbspi-134509	85	30	16	16	NUM
ajbspi-134509	85	31	,	,	PUNCT
ajbspi-134509	85	32	35	35	NUM
ajbspi-134509	85	33	]	]	PUNCT
ajbspi-134509	85	34	.	.	PUNCT
ajbspi-134509	86	1	this	this	DET
ajbspi-134509	86	2	"	"	PUNCT
ajbspi-134509	86	3	yin	yin	PROPN
ajbspi-134509	86	4	and	and	CCONJ
ajbspi-134509	86	5	yang	yang	PROPN
ajbspi-134509	86	6	"	"	PUNCT
ajbspi-134509	86	7	relationship	relationship	NOUN
ajbspi-134509	86	8	between	between	ADP
ajbspi-134509	86	9	extracellular	extracellular	ADJ
ajbspi-134509	86	10	atp	atp	PROPN
ajbspi-134509	86	11	(	(	PUNCT
ajbspi-134509	86	12	pro	pro	ADJ
ajbspi-134509	86	13	-	-	ADJ
ajbspi-134509	86	14	inflammatory	inflammatory	ADJ
ajbspi-134509	86	15	)	)	PUNCT
ajbspi-134509	86	16	and	and	CCONJ
ajbspi-134509	86	17	adenosine	adenosine	NOUN
ajbspi-134509	86	18	(	(	PUNCT
ajbspi-134509	86	19	anti	anti	ADJ
ajbspi-134509	86	20	-	-	ADJ
ajbspi-134509	86	21	inflammatory	inflammatory	ADJ
ajbspi-134509	86	22	)	)	PUNCT
ajbspi-134509	86	23	is	be	AUX
ajbspi-134509	86	24	critical	critical	ADJ
ajbspi-134509	86	25	for	for	ADP
ajbspi-134509	86	26	fine	fine	ADV
ajbspi-134509	86	27	-	-	PUNCT
ajbspi-134509	86	28	tuning	tune	VERB
ajbspi-134509	86	29	immune	immune	ADJ
ajbspi-134509	86	30	responses	response	NOUN
ajbspi-134509	86	31	[	[	X
ajbspi-134509	86	32	16	16	NUM
ajbspi-134509	86	33	,	,	PUNCT
ajbspi-134509	86	34	35	35	NUM
ajbspi-134509	86	35	]	]	PUNCT
ajbspi-134509	86	36	.	.	PUNCT
ajbspi-134509	87	1	impact	impact	NOUN
ajbspi-134509	87	2	on	on	ADP
ajbspi-134509	87	3	specific	specific	ADJ
ajbspi-134509	87	4	immune	immune	ADJ
ajbspi-134509	87	5	cells	cell	NOUN
ajbspi-134509	87	6	adenosine	adenosine	VERB
ajbspi-134509	87	7	exerts	exert	VERB
ajbspi-134509	87	8	its	its	PRON
ajbspi-134509	87	9	effects	effect	NOUN
ajbspi-134509	87	10	on	on	ADP
ajbspi-134509	87	11	virtually	virtually	ADV
ajbspi-134509	87	12	every	every	DET
ajbspi-134509	87	13	immune	immune	ADJ
ajbspi-134509	87	14	cell	cell	NOUN
ajbspi-134509	87	15	type	type	NOUN
ajbspi-134509	87	16	,	,	PUNCT
ajbspi-134509	87	17	modulating	modulate	VERB
ajbspi-134509	87	18	their	their	PRON
ajbspi-134509	87	19	activation	activation	NOUN
ajbspi-134509	87	20	,	,	PUNCT
ajbspi-134509	87	21	proliferation	proliferation	NOUN
ajbspi-134509	87	22	,	,	PUNCT
ajbspi-134509	87	23	cytokine	cytokine	ADJ
ajbspi-134509	87	24	production	production	NOUN
ajbspi-134509	87	25	,	,	PUNCT
ajbspi-134509	87	26	and	and	CCONJ
ajbspi-134509	87	27	migratory	migratory	ADJ
ajbspi-134509	87	28	capabilities	capability	NOUN
ajbspi-134509	87	29	:	:	PUNCT
ajbspi-134509	87	30	•	•	NUM
ajbspi-134509	87	31	neutrophils	neutrophil	NOUN
ajbspi-134509	87	32	:	:	PUNCT
ajbspi-134509	87	33	neutrophils	neutrophil	NOUN
ajbspi-134509	87	34	are	be	AUX
ajbspi-134509	87	35	among	among	ADP
ajbspi-134509	87	36	the	the	DET
ajbspi-134509	87	37	first	first	ADJ
ajbspi-134509	87	38	responders	responder	NOUN
ajbspi-134509	87	39	to	to	ADP
ajbspi-134509	87	40	infection	infection	NOUN
ajbspi-134509	87	41	and	and	CCONJ
ajbspi-134509	87	42	inflammation	inflammation	NOUN
ajbspi-134509	87	43	.	.	PUNCT
ajbspi-134509	88	1	adenosine	adenosine	NOUN
ajbspi-134509	88	2	,	,	PUNCT
ajbspi-134509	88	3	primarily	primarily	ADV
ajbspi-134509	88	4	through	through	ADP
ajbspi-134509	88	5	a2aar	a2aar	DET
ajbspi-134509	88	6	activation	activation	NOUN
ajbspi-134509	88	7	,	,	PUNCT
ajbspi-134509	88	8	significantly	significantly	ADV
ajbspi-134509	88	9	inhibits	inhibit	VERB
ajbspi-134509	88	10	various	various	ADJ
ajbspi-134509	88	11	neutrophil	neutrophil	ADJ
ajbspi-134509	88	12	functions	function	NOUN
ajbspi-134509	88	13	.	.	PUNCT
ajbspi-134509	89	1	this	this	PRON
ajbspi-134509	89	2	includes	include	VERB
ajbspi-134509	89	3	reducing	reduce	VERB
ajbspi-134509	89	4	their	their	PRON
ajbspi-134509	89	5	activation	activation	NOUN
ajbspi-134509	89	6	,	,	PUNCT
ajbspi-134509	89	7	adhesion	adhesion	NOUN
ajbspi-134509	89	8	to	to	ADP
ajbspi-134509	89	9	endothelial	endothelial	ADJ
ajbspi-134509	89	10	cells	cell	NOUN
ajbspi-134509	89	11	,	,	PUNCT
ajbspi-134509	89	12	and	and	CCONJ
ajbspi-134509	89	13	degranulation	degranulation	NOUN
ajbspi-134509	89	14	[	[	X
ajbspi-134509	89	15	18	18	NUM
ajbspi-134509	89	16	,	,	PUNCT
ajbspi-134509	89	17	19	19	NUM
ajbspi-134509	89	18	]	]	PUNCT
ajbspi-134509	89	19	.	.	PUNCT
ajbspi-134509	90	1	specifically	specifically	ADV
ajbspi-134509	90	2	,	,	PUNCT
ajbspi-134509	90	3	a2aar	a2aar	DET
ajbspi-134509	90	4	activation	activation	NOUN
ajbspi-134509	90	5	can	can	AUX
ajbspi-134509	90	6	inhibit	inhibit	VERB
ajbspi-134509	90	7	the	the	DET
ajbspi-134509	90	8	expression	expression	NOUN
ajbspi-134509	90	9	of	of	ADP
ajbspi-134509	90	10	adhesion	adhesion	NOUN
ajbspi-134509	90	11	molecules	molecule	NOUN
ajbspi-134509	90	12	like	like	ADP
ajbspi-134509	90	13	α4	α4	NOUN
ajbspi-134509	90	14	/	/	SYM
ajbspi-134509	90	15	β1	β1	PROPN
ajbspi-134509	90	16	integrin	integrin	NOUN
ajbspi-134509	90	17	(	(	PUNCT
ajbspi-134509	90	18	very	very	ADV
ajbspi-134509	90	19	late	late	ADJ
ajbspi-134509	90	20	antigen-4	antigen-4	NUM
ajbspi-134509	90	21	)	)	PUNCT
ajbspi-134509	90	22	on	on	ADP
ajbspi-134509	90	23	stimulated	stimulate	VERB
ajbspi-134509	90	24	human	human	ADJ
ajbspi-134509	90	25	neutrophils	neutrophil	NOUN
ajbspi-134509	90	26	,	,	PUNCT
ajbspi-134509	90	27	thereby	thereby	ADV
ajbspi-134509	90	28	limiting	limit	VERB
ajbspi-134509	90	29	their	their	PRON
ajbspi-134509	90	30	recruitment	recruitment	NOUN
ajbspi-134509	90	31	to	to	ADP
ajbspi-134509	90	32	inflammatory	inflammatory	ADJ
ajbspi-134509	90	33	sites	site	NOUN
ajbspi-134509	90	34	[	[	X
ajbspi-134509	90	35	20	20	NUM
ajbspi-134509	90	36	]	]	PUNCT
ajbspi-134509	90	37	.	.	PUNCT
ajbspi-134509	91	1	this	this	DET
ajbspi-134509	91	2	inhibition	inhibition	NOUN
ajbspi-134509	91	3	is	be	AUX
ajbspi-134509	91	4	a	a	DET
ajbspi-134509	91	5	crucial	crucial	ADJ
ajbspi-134509	91	6	mechanism	mechanism	NOUN
ajbspi-134509	91	7	by	by	ADP
ajbspi-134509	91	8	which	which	PRON
ajbspi-134509	91	9	adenosine	adenosine	NOUN
ajbspi-134509	91	10	limits	limit	VERB
ajbspi-134509	91	11	neutrophil	neutrophil	ADJ
ajbspi-134509	91	12	-	-	PUNCT
ajbspi-134509	91	13	mediated	mediate	VERB
ajbspi-134509	91	14	tissue	tissue	NOUN
ajbspi-134509	91	15	injury	injury	NOUN
ajbspi-134509	91	16	[	[	X
ajbspi-134509	91	17	19	19	NUM
ajbspi-134509	91	18	]	]	PUNCT
ajbspi-134509	91	19	.	.	PUNCT
ajbspi-134509	92	1	•	•	NOUN
ajbspi-134509	92	2	macrophages	macrophage	NOUN
ajbspi-134509	92	3	:	:	PUNCT
ajbspi-134509	92	4	macrophages	macrophage	NOUN
ajbspi-134509	92	5	are	be	AUX
ajbspi-134509	92	6	highly	highly	ADV
ajbspi-134509	92	7	plastic	plastic	ADJ
ajbspi-134509	92	8	immune	immune	ADJ
ajbspi-134509	92	9	cells	cell	NOUN
ajbspi-134509	92	10	that	that	PRON
ajbspi-134509	92	11	can	can	AUX
ajbspi-134509	92	12	adopt	adopt	VERB
ajbspi-134509	92	13	different	different	ADJ
ajbspi-134509	92	14	functional	functional	ADJ
ajbspi-134509	92	15	phenotypes	phenotype	NOUN
ajbspi-134509	92	16	,	,	PUNCT
ajbspi-134509	92	17	broadly	broadly	ADV
ajbspi-134509	92	18	categorized	categorize	VERB
ajbspi-134509	92	19	as	as	ADP
ajbspi-134509	92	20	pro	pro	ADJ
ajbspi-134509	92	21	-	-	ADJ
ajbspi-134509	92	22	inflammatory	inflammatory	ADJ
ajbspi-134509	92	23	(	(	PUNCT
ajbspi-134509	92	24	m1	m1	NOUN
ajbspi-134509	92	25	)	)	PUNCT
ajbspi-134509	92	26	or	or	CCONJ
ajbspi-134509	92	27	anti	anti	ADJ
ajbspi-134509	92	28	-	-	ADJ
ajbspi-134509	92	29	inflammatory	inflammatory	ADJ
ajbspi-134509	92	30	/	/	SYM
ajbspi-134509	92	31	resolving	resolving	NOUN
ajbspi-134509	92	32	(	(	PUNCT
ajbspi-134509	92	33	m2	m2	PROPN
ajbspi-134509	92	34	)	)	PUNCT
ajbspi-134509	93	1	[	[	X
ajbspi-134509	93	2	23	23	NUM
ajbspi-134509	93	3	]	]	PUNCT
ajbspi-134509	93	4	.	.	PUNCT
ajbspi-134509	94	1	adenosine	adenosine	NOUN
ajbspi-134509	94	2	,	,	PUNCT
ajbspi-134509	94	3	particularly	particularly	ADV
ajbspi-134509	94	4	via	via	ADP
ajbspi-134509	94	5	a2aar	a2aar	DET
ajbspi-134509	94	6	activation	activation	NOUN
ajbspi-134509	94	7	,	,	PUNCT
ajbspi-134509	94	8	plays	play	VERB
ajbspi-134509	94	9	a	a	DET
ajbspi-134509	94	10	significant	significant	ADJ
ajbspi-134509	94	11	role	role	NOUN
ajbspi-134509	94	12	in	in	ADP
ajbspi-134509	94	13	promoting	promote	VERB
ajbspi-134509	94	14	macrophage	macrophage	ADJ
ajbspi-134509	94	15	polarization	polarization	NOUN
ajbspi-134509	94	16	towards	towards	ADP
ajbspi-134509	94	17	an	an	DET
ajbspi-134509	94	18	anti	anti	ADJ
ajbspi-134509	94	19	-	-	ADJ
ajbspi-134509	94	20	inflammatory	inflammatory	ADJ
ajbspi-134509	94	21	m2	m2	PROPN
ajbspi-134509	94	22	phenotype	phenotype	NOUN
ajbspi-134509	94	23	[	[	X
ajbspi-134509	94	24	23	23	NUM
ajbspi-134509	94	25	,	,	PUNCT
ajbspi-134509	94	26	24	24	NUM
ajbspi-134509	94	27	,	,	PUNCT
ajbspi-134509	94	28	26	26	NUM
ajbspi-134509	94	29	]	]	PUNCT
ajbspi-134509	94	30	.	.	PUNCT
ajbspi-134509	95	1	this	this	DET
ajbspi-134509	95	2	shift	shift	NOUN
ajbspi-134509	95	3	is	be	AUX
ajbspi-134509	95	4	characterized	characterize	VERB
ajbspi-134509	95	5	by	by	ADP
ajbspi-134509	95	6	reduced	reduced	ADJ
ajbspi-134509	95	7	production	production	NOUN
ajbspi-134509	95	8	of	of	ADP
ajbspi-134509	95	9	pro	pro	ADJ
ajbspi-134509	95	10	-	-	ADJ
ajbspi-134509	95	11	inflammatory	inflammatory	ADJ
ajbspi-134509	95	12	cytokines	cytokine	NOUN
ajbspi-134509	95	13	and	and	CCONJ
ajbspi-134509	95	14	enhanced	enhance	VERB
ajbspi-134509	95	15	expression	expression	NOUN
ajbspi-134509	95	16	of	of	ADP
ajbspi-134509	95	17	anti	anti	ADJ
ajbspi-134509	95	18	-	-	ADJ
ajbspi-134509	95	19	inflammatory	inflammatory	ADJ
ajbspi-134509	95	20	mediators	mediator	NOUN
ajbspi-134509	95	21	and	and	CCONJ
ajbspi-134509	95	22	tissue	tissue	NOUN
ajbspi-134509	95	23	repair	repair	NOUN
ajbspi-134509	95	24	molecules	molecule	NOUN
ajbspi-134509	95	25	[	[	X
ajbspi-134509	95	26	23	23	NUM
ajbspi-134509	95	27	,	,	PUNCT
ajbspi-134509	95	28	24	24	NUM
ajbspi-134509	95	29	,	,	PUNCT
ajbspi-134509	95	30	26	26	NUM
ajbspi-134509	95	31	]	]	PUNCT
ajbspi-134509	95	32	.	.	PUNCT
ajbspi-134509	96	1	adenosine	adenosine	VERB
ajbspi-134509	96	2	5'-monophosphateactivated	5'-monophosphateactivate	VERB
ajbspi-134509	96	3	protein	protein	NOUN
ajbspi-134509	96	4	kinase	kinase	NOUN
ajbspi-134509	96	5	(	(	PUNCT
ajbspi-134509	96	6	ampk	ampk	PROPN
ajbspi-134509	96	7	)	)	PUNCT
ajbspi-134509	96	8	also	also	ADV
ajbspi-134509	96	9	contributes	contribute	VERB
ajbspi-134509	96	10	to	to	ADP
ajbspi-134509	96	11	this	this	DET
ajbspi-134509	96	12	anti	anti	ADJ
ajbspi-134509	96	13	-	-	ADJ
ajbspi-134509	96	14	inflammatory	inflammatory	ADJ
ajbspi-134509	96	15	polarization	polarization	NOUN
ajbspi-134509	96	16	[	[	X
ajbspi-134509	96	17	24	24	NUM
ajbspi-134509	96	18	]	]	PUNCT
ajbspi-134509	96	19	.	.	PUNCT
ajbspi-134509	97	1	this	this	DET
ajbspi-134509	97	2	macrophage	macrophage	ADJ
ajbspi-134509	97	3	"	"	PUNCT
ajbspi-134509	97	4	class	class	NOUN
ajbspi-134509	97	5	switching	switching	NOUN
ajbspi-134509	97	6	"	"	PUNCT
ajbspi-134509	97	7	from	from	ADP
ajbspi-134509	97	8	lps	lps	PROPN
ajbspi-134509	97	9	-	-	PUNCT
ajbspi-134509	97	10	induced	induce	VERB
ajbspi-134509	97	11	acute	acute	ADJ
ajbspi-134509	97	12	inflammatory	inflammatory	ADJ
ajbspi-134509	97	13	m1	m1	NOUN
ajbspi-134509	97	14	to	to	ADP
ajbspi-134509	97	15	anti	anti	ADJ
ajbspi-134509	97	16	-	-	ADJ
ajbspi-134509	97	17	inflammatory	inflammatory	ADJ
ajbspi-134509	97	18	m2	m2	PROPN
ajbspi-134509	97	19	phenotype	phenotype	NOUN
ajbspi-134509	97	20	is	be	AUX
ajbspi-134509	97	21	a	a	DET
ajbspi-134509	97	22	key	key	ADJ
ajbspi-134509	97	23	mechanism	mechanism	NOUN
ajbspi-134509	97	24	by	by	ADP
ajbspi-134509	97	25	which	which	PRON
ajbspi-134509	97	26	adenosine	adenosine	NOUN
ajbspi-134509	97	27	contributes	contribute	VERB
ajbspi-134509	97	28	to	to	ADP
ajbspi-134509	97	29	the	the	DET
ajbspi-134509	97	30	resolution	resolution	NOUN
ajbspi-134509	97	31	of	of	ADP
ajbspi-134509	97	32	inflammation	inflammation	NOUN
ajbspi-134509	97	33	[	[	X
ajbspi-134509	97	34	26	26	NUM
ajbspi-134509	97	35	]	]	PUNCT
ajbspi-134509	97	36	.	.	PUNCT
ajbspi-134509	98	1	•	•	NUM
ajbspi-134509	98	2	dendritic	dendritic	ADJ
ajbspi-134509	98	3	cells	cell	NOUN
ajbspi-134509	98	4	(	(	PUNCT
ajbspi-134509	98	5	dcs	dcs	PROPN
ajbspi-134509	98	6	):	):	PUNCT
ajbspi-134509	98	7	dendritic	dendritic	ADJ
ajbspi-134509	98	8	cells	cell	NOUN
ajbspi-134509	98	9	are	be	AUX
ajbspi-134509	98	10	professional	professional	ADJ
ajbspi-134509	98	11	antigen	antigen	NOUN
ajbspi-134509	98	12	-	-	PUNCT
ajbspi-134509	98	13	presenting	present	VERB
ajbspi-134509	98	14	cells	cell	NOUN
ajbspi-134509	98	15	that	that	DET
ajbspi-134509	98	16	bridge	bridge	VERB
ajbspi-134509	98	17	innate	innate	ADJ
ajbspi-134509	98	18	and	and	CCONJ
ajbspi-134509	98	19	adaptive	adaptive	ADJ
ajbspi-134509	98	20	immunity	immunity	NOUN
ajbspi-134509	98	21	.	.	PUNCT
ajbspi-134509	99	1	extracellular	extracellular	ADJ
ajbspi-134509	99	2	atp	atp	NOUN
ajbspi-134509	99	3	and	and	CCONJ
ajbspi-134509	99	4	adenosine	adenosine	NOUN
ajbspi-134509	99	5	are	be	AUX
ajbspi-134509	99	6	crucial	crucial	ADJ
ajbspi-134509	99	7	regulators	regulator	NOUN
ajbspi-134509	99	8	of	of	ADP
ajbspi-134509	99	9	dc	dc	PROPN
ajbspi-134509	99	10	activity	activity	NOUN
ajbspi-134509	99	11	[	[	X
ajbspi-134509	99	12	27	27	NUM
ajbspi-134509	99	13	]	]	PUNCT
ajbspi-134509	99	14	.	.	PUNCT
ajbspi-134509	100	1	adenosine	adenosine	PROPN
ajbspi-134509	100	2	affects	affect	VERB
ajbspi-134509	100	3	dc	dc	PROPN
ajbspi-134509	100	4	maturation	maturation	NOUN
ajbspi-134509	100	5	,	,	PUNCT
ajbspi-134509	100	6	cytokine	cytokine	ADJ
ajbspi-134509	100	7	and	and	CCONJ
ajbspi-134509	100	8	chemokine	chemokine	ADJ
ajbspi-134509	100	9	release	release	NOUN
ajbspi-134509	100	10	,	,	PUNCT
ajbspi-134509	100	11	and	and	CCONJ
ajbspi-134509	100	12	their	their	PRON
ajbspi-134509	100	13	capacity	capacity	NOUN
ajbspi-134509	100	14	to	to	PART
ajbspi-134509	100	15	stimulate	stimulate	VERB
ajbspi-134509	100	16	t	t	NOUN
ajbspi-134509	100	17	cells	cell	NOUN
ajbspi-134509	100	18	[	[	X
ajbspi-134509	100	19	29	29	NUM
ajbspi-134509	100	20	]	]	PUNCT
ajbspi-134509	100	21	.	.	PUNCT
ajbspi-134509	101	1	specifically	specifically	ADV
ajbspi-134509	101	2	,	,	PUNCT
ajbspi-134509	101	3	adenosine	adenosine	NOUN
ajbspi-134509	101	4	,	,	PUNCT
ajbspi-134509	101	5	predominantly	predominantly	ADV
ajbspi-134509	101	6	through	through	ADP
ajbspi-134509	101	7	a2aar	a2aar	PRON
ajbspi-134509	101	8	,	,	PUNCT
ajbspi-134509	101	9	inhibits	inhibit	VERB
ajbspi-134509	101	10	dc	dc	PROPN
ajbspi-134509	101	11	differentiation	differentiation	NOUN
ajbspi-134509	101	12	and	and	CCONJ
ajbspi-134509	101	13	function	function	NOUN
ajbspi-134509	101	14	,	,	PUNCT
ajbspi-134509	101	15	leading	lead	VERB
ajbspi-134509	101	16	to	to	ADP
ajbspi-134509	101	17	a	a	DET
ajbspi-134509	101	18	reduced	reduce	VERB
ajbspi-134509	101	19	ability	ability	NOUN
ajbspi-134509	101	20	to	to	PART
ajbspi-134509	101	21	activate	activate	VERB
ajbspi-134509	101	22	t	t	NOUN
ajbspi-134509	101	23	cells	cell	NOUN
ajbspi-134509	101	24	[	[	X
ajbspi-134509	101	25	30	30	NUM
ajbspi-134509	101	26	]	]	PUNCT
ajbspi-134509	101	27	.	.	PUNCT
ajbspi-134509	102	1	cd73	cd73	ADJ
ajbspi-134509	102	2	+	+	SYM
ajbspi-134509	102	3	dendritic	dendritic	ADJ
ajbspi-134509	102	4	cells	cell	NOUN
ajbspi-134509	102	5	have	have	AUX
ajbspi-134509	102	6	been	be	AUX
ajbspi-134509	102	7	implicated	implicate	VERB
ajbspi-134509	102	8	in	in	ADP
ajbspi-134509	102	9	cascading	cascade	VERB
ajbspi-134509	102	10	th17	th17	PROPN
ajbspi-134509	102	11	responses	response	NOUN
ajbspi-134509	102	12	,	,	PUNCT
ajbspi-134509	102	13	suggesting	suggest	VERB
ajbspi-134509	102	14	a	a	DET
ajbspi-134509	102	15	complex	complex	ADJ
ajbspi-134509	102	16	role	role	NOUN
ajbspi-134509	102	17	in	in	ADP
ajbspi-134509	102	18	immune	immune	ADJ
ajbspi-134509	102	19	regulation	regulation	NOUN
ajbspi-134509	102	20	[	[	X
ajbspi-134509	102	21	28	28	NUM
ajbspi-134509	102	22	]	]	PUNCT
ajbspi-134509	102	23	.	.	PUNCT
ajbspi-134509	103	1	this	this	DET
ajbspi-134509	103	2	modulation	modulation	NOUN
ajbspi-134509	103	3	by	by	ADP
ajbspi-134509	103	4	adenosine	adenosine	NOUN
ajbspi-134509	103	5	can	can	AUX
ajbspi-134509	103	6	lead	lead	VERB
ajbspi-134509	103	7	to	to	ADP
ajbspi-134509	103	8	a	a	DET
ajbspi-134509	103	9	less	less	ADV
ajbspi-134509	103	10	robust	robust	ADJ
ajbspi-134509	103	11	adaptive	adaptive	ADJ
ajbspi-134509	103	12	immune	immune	ADJ
ajbspi-134509	103	13	response	response	NOUN
ajbspi-134509	103	14	,	,	PUNCT
ajbspi-134509	103	15	potentially	potentially	ADV
ajbspi-134509	103	16	benefiting	benefit	VERB
ajbspi-134509	103	17	pathogens	pathogen	NOUN
ajbspi-134509	103	18	.	.	PUNCT
ajbspi-134509	104	1	•	•	NUM
ajbspi-134509	104	2	t	t	NOUN
ajbspi-134509	104	3	cells	cell	NOUN
ajbspi-134509	104	4	:	:	PUNCT
ajbspi-134509	104	5	t	t	PROPN
ajbspi-134509	104	6	lymphocytes	lymphocyte	NOUN
ajbspi-134509	104	7	are	be	AUX
ajbspi-134509	104	8	central	central	ADJ
ajbspi-134509	104	9	to	to	ADP
ajbspi-134509	104	10	adaptive	adaptive	ADJ
ajbspi-134509	104	11	immunity	immunity	NOUN
ajbspi-134509	104	12	.	.	PUNCT
ajbspi-134509	105	1	adenosine	adenosine	NOUN
ajbspi-134509	105	2	exerts	exert	VERB
ajbspi-134509	105	3	profound	profound	ADJ
ajbspi-134509	105	4	inhibitory	inhibitory	ADJ
ajbspi-134509	105	5	effects	effect	NOUN
ajbspi-134509	105	6	on	on	ADP
ajbspi-134509	105	7	both	both	CCONJ
ajbspi-134509	105	8	cd4	cd4	PROPN
ajbspi-134509	105	9	+	+	PROPN
ajbspi-134509	105	10	and	and	CCONJ
ajbspi-134509	105	11	cd8	cd8	PROPN
ajbspi-134509	105	12	+	+	PROPN
ajbspi-134509	105	13	t	t	PROPN
ajbspi-134509	105	14	cell	cell	NOUN
ajbspi-134509	105	15	functions	function	NOUN
ajbspi-134509	105	16	:	:	PUNCT
ajbspi-134509	105	17	o	o	X
ajbspi-134509	105	18	cd4	cd4	PROPN
ajbspi-134509	105	19	+	+	PROPN
ajbspi-134509	105	20	t	t	NOUN
ajbspi-134509	105	21	cells	cell	NOUN
ajbspi-134509	105	22	:	:	PUNCT
ajbspi-134509	105	23	adenosine	adenosine	VERB
ajbspi-134509	105	24	a2a	a2a	PROPN
ajbspi-134509	105	25	receptor	receptor	NOUN
ajbspi-134509	105	26	activation	activation	NOUN
ajbspi-134509	105	27	inhibits	inhibit	VERB
ajbspi-134509	105	28	the	the	DET
ajbspi-134509	105	29	development	development	NOUN
ajbspi-134509	105	30	and	and	CCONJ
ajbspi-134509	105	31	effector	effector	NOUN
ajbspi-134509	105	32	function	function	NOUN
ajbspi-134509	105	33	of	of	ADP
ajbspi-134509	105	34	both	both	DET
ajbspi-134509	105	35	t	t	PROPN
ajbspi-134509	105	36	helper	helper	NOUN
ajbspi-134509	106	1	1	1	NUM
ajbspi-134509	106	2	(	(	PUNCT
ajbspi-134509	106	3	th1	th1	NOUN
ajbspi-134509	106	4	)	)	PUNCT
ajbspi-134509	106	5	and	and	CCONJ
ajbspi-134509	106	6	t	t	PROPN
ajbspi-134509	106	7	helper	helper	NOUN
ajbspi-134509	106	8	2	2	NUM
ajbspi-134509	106	9	(	(	PUNCT
ajbspi-134509	106	10	th2	th2	PROPN
ajbspi-134509	106	11	)	)	PUNCT
ajbspi-134509	106	12	cells	cell	NOUN
ajbspi-134509	107	1	[	[	X
ajbspi-134509	107	2	33	33	NUM
ajbspi-134509	107	3	]	]	PUNCT
ajbspi-134509	107	4	.	.	PUNCT
ajbspi-134509	108	1	it	it	PRON
ajbspi-134509	108	2	directly	directly	ADV
ajbspi-134509	108	3	inhibits	inhibit	VERB
ajbspi-134509	108	4	il-2	il-2	NUM
ajbspi-134509	108	5	secretion	secretion	NOUN
ajbspi-134509	108	6	and	and	CCONJ
ajbspi-134509	108	7	il-2driven	il-2driven	ADJ
ajbspi-134509	108	8	expansion	expansion	NOUN
ajbspi-134509	108	9	in	in	ADP
ajbspi-134509	108	10	th1	th1	PROPN
ajbspi-134509	108	11	and	and	CCONJ
ajbspi-134509	108	12	tc1	tc1	PROPN
ajbspi-134509	108	13	cells	cell	NOUN
ajbspi-134509	108	14	[	[	X
ajbspi-134509	108	15	34	34	NUM
ajbspi-134509	108	16	]	]	PUNCT
ajbspi-134509	108	17	.	.	PUNCT
ajbspi-134509	109	1	furthermore	furthermore	ADV
ajbspi-134509	109	2	,	,	PUNCT
ajbspi-134509	109	3	a2aar	a2aar	DET
ajbspi-134509	109	4	induction	induction	NOUN
ajbspi-134509	109	5	can	can	AUX
ajbspi-134509	109	6	inhibit	inhibit	VERB
ajbspi-134509	109	7	ifn	ifn	PROPN
ajbspi-134509	109	8	-	-	PUNCT
ajbspi-134509	109	9	γ	γ	NOUN
ajbspi-134509	109	10	production	production	NOUN
ajbspi-134509	109	11	in	in	ADP
ajbspi-134509	109	12	murine	murine	ADJ
ajbspi-134509	109	13	cd4	cd4	PROPN
ajbspi-134509	109	14	+	+	PROPN
ajbspi-134509	109	15	t	t	NOUN
ajbspi-134509	109	16	cells	cell	NOUN
ajbspi-134509	109	17	[	[	X
ajbspi-134509	109	18	35	35	NUM
ajbspi-134509	109	19	]	]	PUNCT
ajbspi-134509	109	20	.	.	PUNCT
ajbspi-134509	110	1	this	this	DET
ajbspi-134509	110	2	broad	broad	ADJ
ajbspi-134509	110	3	suppression	suppression	NOUN
ajbspi-134509	110	4	of	of	ADP
ajbspi-134509	110	5	th1	th1	PROPN
ajbspi-134509	110	6	and	and	CCONJ
ajbspi-134509	110	7	th2	th2	PROPN
ajbspi-134509	110	8	responses	response	NOUN
ajbspi-134509	110	9	can	can	AUX
ajbspi-134509	110	10	limit	limit	VERB
ajbspi-134509	110	11	the	the	DET
ajbspi-134509	110	12	host	host	NOUN
ajbspi-134509	110	13	's	's	PART
ajbspi-134509	110	14	ability	ability	NOUN
ajbspi-134509	110	15	to	to	PART
ajbspi-134509	110	16	mount	mount	VERB
ajbspi-134509	110	17	effective	effective	ADJ
ajbspi-134509	110	18	cell	cell	NOUN
ajbspi-134509	110	19	-	-	PUNCT
ajbspi-134509	110	20	mediated	mediate	VERB
ajbspi-134509	110	21	and	and	CCONJ
ajbspi-134509	110	22	humoral	humoral	ADJ
ajbspi-134509	110	23	immunity	immunity	NOUN
ajbspi-134509	110	24	against	against	ADP
ajbspi-134509	110	25	pathogens	pathogen	NOUN
ajbspi-134509	110	26	.	.	PUNCT
ajbspi-134509	111	1	o	o	X
ajbspi-134509	112	1	cd8	cd8	PROPN
ajbspi-134509	112	2	+	+	PROPN
ajbspi-134509	112	3	t	t	PROPN
ajbspi-134509	112	4	cells	cell	NOUN
ajbspi-134509	112	5	:	:	PUNCT
ajbspi-134509	112	6	adenosine	adenosine	NOUN
ajbspi-134509	112	7	mediates	mediate	NOUN
ajbspi-134509	112	8	functional	functional	ADJ
ajbspi-134509	112	9	and	and	CCONJ
ajbspi-134509	112	10	metabolic	metabolic	NOUN
ajbspi-134509	112	11	suppression	suppression	NOUN
ajbspi-134509	112	12	of	of	ADP
ajbspi-134509	112	13	both	both	CCONJ
ajbspi-134509	112	14	peripheral	peripheral	ADJ
ajbspi-134509	112	15	and	and	CCONJ
ajbspi-134509	112	16	tumor	tumor	NOUN
ajbspi-134509	112	17	-	-	PUNCT
ajbspi-134509	112	18	infiltrating	infiltrate	VERB
ajbspi-134509	112	19	cd8	cd8	PROPN
ajbspi-134509	112	20	+	+	PROPN
ajbspi-134509	112	21	t	t	PROPN
ajbspi-134509	112	22	cells	cell	NOUN
ajbspi-134509	112	23	[	[	X
ajbspi-134509	112	24	51	51	NUM
ajbspi-134509	112	25	]	]	PUNCT
ajbspi-134509	112	26	.	.	PUNCT
ajbspi-134509	113	1	this	this	DET
ajbspi-134509	113	2	suppression	suppression	NOUN
ajbspi-134509	113	3	can	can	AUX
ajbspi-134509	113	4	lead	lead	VERB
ajbspi-134509	113	5	to	to	ADP
ajbspi-134509	113	6	t	t	NOUN
ajbspi-134509	113	7	cell	cell	NOUN
ajbspi-134509	113	8	exclusion	exclusion	NOUN
ajbspi-134509	113	9	and	and	CCONJ
ajbspi-134509	113	10	dysfunction	dysfunction	NOUN
ajbspi-134509	113	11	,	,	PUNCT
ajbspi-134509	113	12	contributing	contribute	VERB
ajbspi-134509	113	13	to	to	ADP
ajbspi-134509	113	14	immune	immune	ADJ
ajbspi-134509	113	15	evasion	evasion	NOUN
ajbspi-134509	113	16	[	[	X
ajbspi-134509	113	17	52	52	NUM
ajbspi-134509	113	18	]	]	PUNCT
ajbspi-134509	113	19	.	.	PUNCT
ajbspi-134509	114	1	cd39	cd39	NOUN
ajbspi-134509	114	2	expression	expression	NOUN
ajbspi-134509	114	3	on	on	ADP
ajbspi-134509	114	4	cd8	cd8	PROPN
ajbspi-134509	114	5	+	+	PROPN
ajbspi-134509	114	6	t	t	NOUN
ajbspi-134509	114	7	cells	cell	NOUN
ajbspi-134509	114	8	has	have	AUX
ajbspi-134509	114	9	been	be	AUX
ajbspi-134509	114	10	shown	show	VERB
ajbspi-134509	114	11	to	to	PART
ajbspi-134509	114	12	modulate	modulate	VERB
ajbspi-134509	114	13	interferon	interferon	ADJ
ajbspi-134509	114	14	gamma	gamma	NOUN
ajbspi-134509	114	15	responses	response	NOUN
ajbspi-134509	114	16	via	via	ADP
ajbspi-134509	114	17	adenosine	adenosine	NOUN
ajbspi-134509	114	18	generation	generation	NOUN
ajbspi-134509	115	1	[	[	X
ajbspi-134509	115	2	49	49	NUM
ajbspi-134509	115	3	]	]	PUNCT
ajbspi-134509	115	4	.	.	PUNCT
ajbspi-134509	116	1	enhanced	enhance	VERB
ajbspi-134509	116	2	expression	expression	NOUN
ajbspi-134509	116	3	of	of	ADP
ajbspi-134509	116	4	cd39	cd39	PROPN
ajbspi-134509	116	5	and	and	CCONJ
ajbspi-134509	116	6	cd73	cd73	PROPN
ajbspi-134509	116	7	on	on	ADP
ajbspi-134509	116	8	t	t	NOUN
ajbspi-134509	116	9	cells	cell	NOUN
ajbspi-134509	116	10	is	be	AUX
ajbspi-134509	116	11	observed	observe	VERB
ajbspi-134509	116	12	in	in	ADP
ajbspi-134509	116	13	the	the	DET
ajbspi-134509	116	14	regulation	regulation	NOUN
ajbspi-134509	116	15	of	of	ADP
ajbspi-134509	116	16	anti	anti	ADJ
ajbspi-134509	116	17	-	-	ADJ
ajbspi-134509	116	18	tumor	tumor	ADJ
ajbspi-134509	116	19	immune	immune	ADJ
ajbspi-134509	116	20	responses	response	NOUN
ajbspi-134509	116	21	,	,	PUNCT
ajbspi-134509	116	22	where	where	SCONJ
ajbspi-134509	116	23	they	they	PRON
ajbspi-134509	116	24	contribute	contribute	VERB
ajbspi-134509	116	25	to	to	ADP
ajbspi-134509	116	26	an	an	DET
ajbspi-134509	116	27	immunosuppressive	immunosuppressive	ADJ
ajbspi-134509	116	28	environment	environment	NOUN
ajbspi-134509	116	29	[	[	X
ajbspi-134509	116	30	36	36	NUM
ajbspi-134509	116	31	,	,	PUNCT
ajbspi-134509	116	32	37	37	NUM
ajbspi-134509	116	33	,	,	PUNCT
ajbspi-134509	116	34	38	38	NUM
ajbspi-134509	116	35	,	,	PUNCT
ajbspi-134509	116	36	39	39	NUM
ajbspi-134509	116	37	,	,	PUNCT
ajbspi-134509	116	38	40	40	NUM
ajbspi-134509	116	39	,	,	PUNCT
ajbspi-134509	116	40	41	41	NUM
ajbspi-134509	116	41	,	,	PUNCT
ajbspi-134509	116	42	42	42	NUM
ajbspi-134509	116	43	]	]	PUNCT
ajbspi-134509	116	44	.	.	PUNCT
ajbspi-134509	117	1	this	this	DET
ajbspi-134509	117	2	ectonucleotidase	ectonucleotidase	ADJ
ajbspi-134509	117	3	activity	activity	NOUN
ajbspi-134509	117	4	contributes	contribute	VERB
ajbspi-134509	117	5	to	to	ADP
ajbspi-134509	117	6	the	the	DET
ajbspi-134509	117	7	generation	generation	NOUN
ajbspi-134509	117	8	of	of	ADP
ajbspi-134509	117	9	adenosine	adenosine	NOUN
ajbspi-134509	117	10	,	,	PUNCT
ajbspi-134509	117	11	which	which	PRON
ajbspi-134509	117	12	then	then	ADV
ajbspi-134509	117	13	suppresses	suppress	VERB
ajbspi-134509	117	14	t	t	PROPN
ajbspi-134509	117	15	cell	cell	NOUN
ajbspi-134509	117	16	function	function	NOUN
ajbspi-134509	117	17	,	,	PUNCT
ajbspi-134509	117	18	potentially	potentially	ADV
ajbspi-134509	117	19	leading	lead	VERB
ajbspi-134509	117	20	to	to	ADP
ajbspi-134509	117	21	t	t	NOUN
ajbspi-134509	117	22	cell	cell	NOUN
ajbspi-134509	117	23	exhaustion	exhaustion	NOUN
ajbspi-134509	117	24	,	,	PUNCT
ajbspi-134509	117	25	characterized	characterize	VERB
ajbspi-134509	117	26	by	by	ADP
ajbspi-134509	117	27	high	high	ADJ
ajbspi-134509	117	28	cd39	cd39	PROPN
ajbspi-134509	117	29	expression	expression	NOUN
ajbspi-134509	117	30	[	[	X
ajbspi-134509	117	31	53	53	NUM
ajbspi-134509	117	32	]	]	PUNCT
ajbspi-134509	117	33	.	.	PUNCT
ajbspi-134509	118	1	o	o	X
ajbspi-134509	118	2	regulatory	regulatory	ADJ
ajbspi-134509	118	3	t	t	PROPN
ajbspi-134509	118	4	cells	cell	NOUN
ajbspi-134509	118	5	(	(	PUNCT
ajbspi-134509	118	6	tregs	treg	NOUN
ajbspi-134509	118	7	):	):	PUNCT
ajbspi-134509	118	8	in	in	ADP
ajbspi-134509	118	9	contrast	contrast	NOUN
ajbspi-134509	118	10	to	to	ADP
ajbspi-134509	118	11	its	its	PRON
ajbspi-134509	118	12	american	american	ADJ
ajbspi-134509	118	13	journal	journal	NOUN
ajbspi-134509	118	14	of	of	ADP
ajbspi-134509	118	15	applied	apply	VERB
ajbspi-134509	118	16	science	science	NOUN
ajbspi-134509	118	17	and	and	CCONJ
ajbspi-134509	118	18	technology	technology	NOUN
ajbspi-134509	118	19	5	5	NUM
ajbspi-134509	118	20	https://theusajournals.com/index.php/ajast	https://theusajournals.com/index.php/ajast	NOUN
ajbspi-134509	118	21	american	american	PROPN
ajbspi-134509	118	22	journal	journal	PROPN
ajbspi-134509	118	23	of	of	ADP
ajbspi-134509	118	24	applied	apply	VERB
ajbspi-134509	118	25	science	science	NOUN
ajbspi-134509	118	26	and	and	CCONJ
ajbspi-134509	118	27	technology	technology	NOUN
ajbspi-134509	118	28	(	(	PUNCT
ajbspi-134509	118	29	issn	issn	PROPN
ajbspi-134509	118	30	:	:	PUNCT
ajbspi-134509	118	31	2771	2771	NUM
ajbspi-134509	118	32	-	-	SYM
ajbspi-134509	118	33	2745	2745	NUM
ajbspi-134509	118	34	)	)	PUNCT
ajbspi-134509	118	35	inhibitory	inhibitory	ADJ
ajbspi-134509	118	36	effects	effect	NOUN
ajbspi-134509	118	37	on	on	ADP
ajbspi-134509	118	38	effector	effector	NOUN
ajbspi-134509	118	39	t	t	NOUN
ajbspi-134509	118	40	cells	cell	NOUN
ajbspi-134509	118	41	,	,	PUNCT
ajbspi-134509	118	42	the	the	DET
ajbspi-134509	118	43	adenosine	adenosine	NOUN
ajbspi-134509	118	44	-	-	PUNCT
ajbspi-134509	118	45	a2a	a2a	NOUN
ajbspi-134509	118	46	adenosine	adenosine	NOUN
ajbspi-134509	118	47	receptor	receptor	NOUN
ajbspi-134509	118	48	pathway	pathway	NOUN
ajbspi-134509	118	49	plays	play	VERB
ajbspi-134509	118	50	a	a	DET
ajbspi-134509	118	51	critical	critical	ADJ
ajbspi-134509	118	52	role	role	NOUN
ajbspi-134509	118	53	in	in	ADP
ajbspi-134509	118	54	the	the	DET
ajbspi-134509	118	55	development	development	NOUN
ajbspi-134509	118	56	and	and	CCONJ
ajbspi-134509	118	57	immunosuppressive	immunosuppressive	ADJ
ajbspi-134509	118	58	functions	function	NOUN
ajbspi-134509	118	59	of	of	ADP
ajbspi-134509	118	60	cd4	cd4	PROPN
ajbspi-134509	118	61	+	+	PROPN
ajbspi-134509	118	62	cd25	cd25	PROPN
ajbspi-134509	118	63	+	+	SYM
ajbspi-134509	118	64	foxp3	foxp3	NOUN
ajbspi-134509	118	65	+	+	SYM
ajbspi-134509	118	66	regulatory	regulatory	ADJ
ajbspi-134509	118	67	t	t	NOUN
ajbspi-134509	118	68	cells	cell	NOUN
ajbspi-134509	118	69	[	[	X
ajbspi-134509	118	70	50	50	NUM
ajbspi-134509	118	71	,	,	PUNCT
ajbspi-134509	118	72	51	51	NUM
ajbspi-134509	118	73	]	]	PUNCT
ajbspi-134509	118	74	.	.	PUNCT
ajbspi-134509	119	1	tregs	treg	NOUN
ajbspi-134509	119	2	are	be	AUX
ajbspi-134509	119	3	essential	essential	ADJ
ajbspi-134509	119	4	for	for	ADP
ajbspi-134509	119	5	maintaining	maintain	VERB
ajbspi-134509	119	6	immune	immune	ADJ
ajbspi-134509	119	7	tolerance	tolerance	NOUN
ajbspi-134509	119	8	and	and	CCONJ
ajbspi-134509	119	9	preventing	prevent	VERB
ajbspi-134509	119	10	autoimmunity	autoimmunity	NOUN
ajbspi-134509	119	11	,	,	PUNCT
ajbspi-134509	119	12	but	but	CCONJ
ajbspi-134509	119	13	their	their	PRON
ajbspi-134509	119	14	enhanced	enhance	VERB
ajbspi-134509	119	15	function	function	NOUN
ajbspi-134509	119	16	can	can	AUX
ajbspi-134509	119	17	also	also	ADV
ajbspi-134509	119	18	suppress	suppress	VERB
ajbspi-134509	119	19	anti	anti	ADJ
ajbspi-134509	119	20	-	-	NOUN
ajbspi-134509	119	21	pathogen	pathogen	NOUN
ajbspi-134509	119	22	immunity	immunity	NOUN
ajbspi-134509	119	23	.	.	PUNCT
ajbspi-134509	120	1	•	•	NUM
ajbspi-134509	120	2	b	b	X
ajbspi-134509	120	3	cells	cell	NOUN
ajbspi-134509	120	4	:	:	PUNCT
ajbspi-134509	120	5	b	b	NUM
ajbspi-134509	120	6	lymphocytes	lymphocyte	NOUN
ajbspi-134509	120	7	are	be	AUX
ajbspi-134509	120	8	also	also	ADV
ajbspi-134509	120	9	influenced	influence	VERB
ajbspi-134509	120	10	by	by	ADP
ajbspi-134509	120	11	the	the	DET
ajbspi-134509	120	12	adenosine	adenosine	NOUN
ajbspi-134509	120	13	system	system	NOUN
ajbspi-134509	120	14	.	.	PUNCT
ajbspi-134509	121	1	human	human	PROPN
ajbspi-134509	121	2	b	b	PROPN
ajbspi-134509	121	3	cells	cell	NOUN
ajbspi-134509	121	4	are	be	AUX
ajbspi-134509	121	5	capable	capable	ADJ
ajbspi-134509	121	6	of	of	ADP
ajbspi-134509	121	7	producing	produce	VERB
ajbspi-134509	121	8	adenosine	adenosine	NOUN
ajbspi-134509	121	9	through	through	ADP
ajbspi-134509	121	10	a	a	DET
ajbspi-134509	121	11	cd38	cd38	PROPN
ajbspi-134509	121	12	-	-	PUNCT
ajbspi-134509	121	13	mediated	mediate	VERB
ajbspi-134509	121	14	pathway	pathway	NOUN
ajbspi-134509	121	15	,	,	PUNCT
ajbspi-134509	121	16	and	and	CCONJ
ajbspi-134509	121	17	this	this	DET
ajbspi-134509	121	18	adenosine	adenosine	NOUN
ajbspi-134509	121	19	contributes	contribute	VERB
ajbspi-134509	121	20	to	to	ADP
ajbspi-134509	121	21	their	their	PRON
ajbspi-134509	121	22	ability	ability	NOUN
ajbspi-134509	121	23	to	to	PART
ajbspi-134509	121	24	suppress	suppress	VERB
ajbspi-134509	121	25	activated	activate	VERB
ajbspi-134509	121	26	t	t	NOUN
ajbspi-134509	121	27	cells	cell	NOUN
ajbspi-134509	121	28	[	[	X
ajbspi-134509	121	29	54	54	NUM
ajbspi-134509	121	30	]	]	PUNCT
ajbspi-134509	121	31	.	.	PUNCT
ajbspi-134509	122	1	a	a	DET
ajbspi-134509	122	2	skewed	skewed	ADJ
ajbspi-134509	122	3	cd39	cd39	PROPN
ajbspi-134509	122	4	/	/	SYM
ajbspi-134509	122	5	cd73	cd73	PROPN
ajbspi-134509	122	6	/	/	SYM
ajbspi-134509	122	7	adenosine	adenosine	NOUN
ajbspi-134509	122	8	pathway	pathway	NOUN
ajbspi-134509	122	9	in	in	ADP
ajbspi-134509	122	10	b	b	NOUN
ajbspi-134509	122	11	cells	cell	NOUN
ajbspi-134509	122	12	has	have	AUX
ajbspi-134509	122	13	been	be	AUX
ajbspi-134509	122	14	associated	associate	VERB
ajbspi-134509	122	15	with	with	ADP
ajbspi-134509	122	16	innate	innate	ADJ
ajbspi-134509	122	17	immune	immune	ADJ
ajbspi-134509	122	18	hyperactivation	hyperactivation	NOUN
ajbspi-134509	122	19	in	in	ADP
ajbspi-134509	122	20	chronic	chronic	ADJ
ajbspi-134509	122	21	hiv-1	hiv-1	PART
ajbspi-134509	122	22	infection	infection	NOUN
ajbspi-134509	122	23	,	,	PUNCT
ajbspi-134509	122	24	suggesting	suggest	VERB
ajbspi-134509	122	25	a	a	DET
ajbspi-134509	122	26	role	role	NOUN
ajbspi-134509	122	27	in	in	ADP
ajbspi-134509	122	28	modulating	modulate	VERB
ajbspi-134509	122	29	immune	immune	ADJ
ajbspi-134509	122	30	responses	response	NOUN
ajbspi-134509	122	31	during	during	ADP
ajbspi-134509	122	32	chronic	chronic	ADJ
ajbspi-134509	122	33	infections	infection	NOUN
ajbspi-134509	122	34	[	[	X
ajbspi-134509	122	35	55	55	NUM
ajbspi-134509	122	36	]	]	PUNCT
ajbspi-134509	122	37	.	.	PUNCT
ajbspi-134509	123	1	furthermore	furthermore	ADV
ajbspi-134509	123	2	,	,	PUNCT
ajbspi-134509	123	3	immunoglobulin	immunoglobulin	NOUN
ajbspi-134509	123	4	class	class	NOUN
ajbspi-134509	123	5	switch	switch	NOUN
ajbspi-134509	123	6	recombination	recombination	NOUN
ajbspi-134509	123	7	in	in	ADP
ajbspi-134509	123	8	b	b	NOUN
ajbspi-134509	123	9	cells	cell	NOUN
ajbspi-134509	123	10	is	be	AUX
ajbspi-134509	123	11	dependent	dependent	ADJ
ajbspi-134509	123	12	on	on	ADP
ajbspi-134509	123	13	the	the	DET
ajbspi-134509	123	14	vesicular	vesicular	ADJ
ajbspi-134509	123	15	release	release	NOUN
ajbspi-134509	123	16	of	of	ADP
ajbspi-134509	123	17	atp	atp	PROPN
ajbspi-134509	123	18	and	and	CCONJ
ajbspi-134509	123	19	cd73	cd73	PROPN
ajbspi-134509	123	20	ectonucleotidase	ectonucleotidase	ADJ
ajbspi-134509	123	21	activity	activity	NOUN
ajbspi-134509	123	22	[	[	X
ajbspi-134509	123	23	56	56	NUM
ajbspi-134509	123	24	]	]	PUNCT
ajbspi-134509	123	25	.	.	PUNCT
ajbspi-134509	124	1	cd39	cd39	PROPN
ajbspi-134509	124	2	high	high	ADJ
ajbspi-134509	124	3	human	human	ADJ
ajbspi-134509	124	4	regulatory	regulatory	ADJ
ajbspi-134509	124	5	b	b	PROPN
ajbspi-134509	124	6	cells	cell	NOUN
ajbspi-134509	124	7	(	(	PUNCT
ajbspi-134509	124	8	breg	breg	PROPN
ajbspi-134509	124	9	)	)	PUNCT
ajbspi-134509	124	10	also	also	ADV
ajbspi-134509	124	11	exhibit	exhibit	VERB
ajbspi-134509	124	12	specific	specific	ADJ
ajbspi-134509	124	13	phenotypic	phenotypic	ADJ
ajbspi-134509	124	14	and	and	CCONJ
ajbspi-134509	124	15	functional	functional	ADJ
ajbspi-134509	124	16	characteristics	characteristic	NOUN
ajbspi-134509	124	17	,	,	PUNCT
ajbspi-134509	124	18	contributing	contribute	VERB
ajbspi-134509	124	19	to	to	ADP
ajbspi-134509	124	20	immunosuppression	immunosuppression	NOUN
ajbspi-134509	124	21	[	[	X
ajbspi-134509	124	22	57	57	NUM
ajbspi-134509	124	23	]	]	PUNCT
ajbspi-134509	124	24	.	.	PUNCT
ajbspi-134509	125	1	the	the	DET
ajbspi-134509	125	2	specific	specific	ADJ
ajbspi-134509	125	3	decrease	decrease	NOUN
ajbspi-134509	125	4	in	in	ADP
ajbspi-134509	125	5	b	b	NOUN
ajbspi-134509	125	6	-	-	PUNCT
ajbspi-134509	125	7	cell	cell	NOUN
ajbspi-134509	125	8	-	-	PUNCT
ajbspi-134509	125	9	derived	derive	VERB
ajbspi-134509	125	10	extracellular	extracellular	ADJ
ajbspi-134509	125	11	vesicles	vesicle	NOUN
ajbspi-134509	125	12	can	can	AUX
ajbspi-134509	125	13	enhance	enhance	VERB
ajbspi-134509	125	14	post	post	ADJ
ajbspi-134509	125	15	-	-	ADJ
ajbspi-134509	125	16	chemotherapeutic	chemotherapeutic	ADJ
ajbspi-134509	125	17	cd8	cd8	PROPN
ajbspi-134509	125	18	+	+	PROPN
ajbspi-134509	125	19	t	t	NOUN
ajbspi-134509	125	20	cell	cell	NOUN
ajbspi-134509	125	21	responses	response	NOUN
ajbspi-134509	125	22	,	,	PUNCT
ajbspi-134509	125	23	highlighting	highlight	VERB
ajbspi-134509	125	24	the	the	DET
ajbspi-134509	125	25	complex	complex	ADJ
ajbspi-134509	125	26	interplay	interplay	NOUN
ajbspi-134509	125	27	[	[	X
ajbspi-134509	125	28	58	58	NUM
ajbspi-134509	125	29	]	]	PUNCT
ajbspi-134509	125	30	.	.	PUNCT
ajbspi-134509	126	1	•	•	NUM
ajbspi-134509	126	2	natural	natural	ADJ
ajbspi-134509	126	3	killer	killer	NOUN
ajbspi-134509	126	4	(	(	PUNCT
ajbspi-134509	126	5	nk	nk	PROPN
ajbspi-134509	126	6	)	)	PUNCT
ajbspi-134509	126	7	cells	cell	NOUN
ajbspi-134509	126	8	:	:	PUNCT
ajbspi-134509	126	9	nk	nk	PROPN
ajbspi-134509	126	10	cells	cell	NOUN
ajbspi-134509	126	11	are	be	AUX
ajbspi-134509	126	12	crucial	crucial	ADJ
ajbspi-134509	126	13	components	component	NOUN
ajbspi-134509	126	14	of	of	ADP
ajbspi-134509	126	15	innate	innate	ADJ
ajbspi-134509	126	16	immunity	immunity	NOUN
ajbspi-134509	126	17	.	.	PUNCT
ajbspi-134509	127	1	functional	functional	ADJ
ajbspi-134509	127	2	expression	expression	NOUN
ajbspi-134509	127	3	of	of	ADP
ajbspi-134509	127	4	cd73	cd73	PROPN
ajbspi-134509	127	5	has	have	AUX
ajbspi-134509	127	6	been	be	AUX
ajbspi-134509	127	7	observed	observe	VERB
ajbspi-134509	127	8	on	on	ADP
ajbspi-134509	127	9	human	human	ADJ
ajbspi-134509	127	10	natural	natural	ADJ
ajbspi-134509	127	11	killer	killer	NOUN
ajbspi-134509	127	12	cells	cell	NOUN
ajbspi-134509	127	13	[	[	X
ajbspi-134509	127	14	41	41	NUM
ajbspi-134509	127	15	]	]	PUNCT
ajbspi-134509	127	16	.	.	PUNCT
ajbspi-134509	128	1	cd56brightcd16nk	cd56brightcd16nk	NUM
ajbspi-134509	128	2	cells	cell	NOUN
ajbspi-134509	128	3	can	can	AUX
ajbspi-134509	128	4	produce	produce	VERB
ajbspi-134509	128	5	adenosine	adenosine	NOUN
ajbspi-134509	128	6	through	through	ADP
ajbspi-134509	128	7	a	a	DET
ajbspi-134509	128	8	cd38	cd38	PROPN
ajbspi-134509	128	9	-	-	PUNCT
ajbspi-134509	128	10	mediated	mediate	VERB
ajbspi-134509	128	11	pathway	pathway	NOUN
ajbspi-134509	128	12	and	and	CCONJ
ajbspi-134509	128	13	act	act	VERB
ajbspi-134509	128	14	as	as	ADP
ajbspi-134509	128	15	regulatory	regulatory	ADJ
ajbspi-134509	128	16	cells	cell	NOUN
ajbspi-134509	128	17	,	,	PUNCT
ajbspi-134509	128	18	inhibiting	inhibit	VERB
ajbspi-134509	128	19	autologous	autologous	ADJ
ajbspi-134509	128	20	cd4	cd4	PROPN
ajbspi-134509	128	21	+	+	PROPN
ajbspi-134509	128	22	t	t	NOUN
ajbspi-134509	128	23	cell	cell	NOUN
ajbspi-134509	128	24	proliferation	proliferation	NOUN
ajbspi-134509	128	25	[	[	X
ajbspi-134509	128	26	42	42	NUM
ajbspi-134509	128	27	]	]	PUNCT
ajbspi-134509	128	28	.	.	PUNCT
ajbspi-134509	129	1	this	this	PRON
ajbspi-134509	129	2	indicates	indicate	VERB
ajbspi-134509	129	3	that	that	SCONJ
ajbspi-134509	129	4	nk	nk	PROPN
ajbspi-134509	129	5	cells	cell	NOUN
ajbspi-134509	129	6	can	can	AUX
ajbspi-134509	129	7	also	also	ADV
ajbspi-134509	129	8	contribute	contribute	VERB
ajbspi-134509	129	9	to	to	ADP
ajbspi-134509	129	10	the	the	DET
ajbspi-134509	129	11	local	local	ADJ
ajbspi-134509	129	12	adenosine	adenosine	NOUN
ajbspi-134509	129	13	-	-	PUNCT
ajbspi-134509	129	14	mediated	mediate	VERB
ajbspi-134509	129	15	immunosuppressive	immunosuppressive	ADJ
ajbspi-134509	129	16	environment	environment	NOUN
ajbspi-134509	129	17	.	.	PUNCT
ajbspi-134509	130	1	•	•	NOUN
ajbspi-134509	130	2	myeloid	myeloid	NOUN
ajbspi-134509	130	3	-	-	PUNCT
ajbspi-134509	130	4	derived	derive	VERB
ajbspi-134509	130	5	suppressor	suppressor	NOUN
ajbspi-134509	130	6	cells	cell	NOUN
ajbspi-134509	130	7	(	(	PUNCT
ajbspi-134509	130	8	mdscs	mdsc	NOUN
ajbspi-134509	130	9	):	):	PUNCT
ajbspi-134509	130	10	mdscs	mdsc	NOUN
ajbspi-134509	130	11	are	be	AUX
ajbspi-134509	130	12	a	a	DET
ajbspi-134509	130	13	heterogeneous	heterogeneous	ADJ
ajbspi-134509	130	14	population	population	NOUN
ajbspi-134509	130	15	of	of	ADP
ajbspi-134509	130	16	immature	immature	ADJ
ajbspi-134509	130	17	myeloid	myeloid	ADJ
ajbspi-134509	130	18	cells	cell	NOUN
ajbspi-134509	130	19	that	that	PRON
ajbspi-134509	130	20	expand	expand	VERB
ajbspi-134509	130	21	during	during	ADP
ajbspi-134509	130	22	cancer	cancer	NOUN
ajbspi-134509	130	23	and	and	CCONJ
ajbspi-134509	130	24	chronic	chronic	ADJ
ajbspi-134509	130	25	inflammation	inflammation	NOUN
ajbspi-134509	130	26	,	,	PUNCT
ajbspi-134509	130	27	exerting	exert	VERB
ajbspi-134509	130	28	potent	potent	ADJ
ajbspi-134509	130	29	immunosuppressive	immunosuppressive	ADJ
ajbspi-134509	130	30	effects	effect	NOUN
ajbspi-134509	130	31	[	[	X
ajbspi-134509	130	32	36	36	NUM
ajbspi-134509	130	33	,	,	PUNCT
ajbspi-134509	130	34	37	37	NUM
ajbspi-134509	130	35	,	,	PUNCT
ajbspi-134509	130	36	38	38	NUM
ajbspi-134509	130	37	,	,	PUNCT
ajbspi-134509	130	38	39	39	NUM
ajbspi-134509	130	39	,	,	PUNCT
ajbspi-134509	130	40	40	40	NUM
ajbspi-134509	130	41	]	]	PUNCT
ajbspi-134509	130	42	.	.	PUNCT
ajbspi-134509	131	1	a	a	DET
ajbspi-134509	131	2	key	key	ADJ
ajbspi-134509	131	3	mechanism	mechanism	NOUN
ajbspi-134509	131	4	of	of	ADP
ajbspi-134509	131	5	their	their	PRON
ajbspi-134509	131	6	immunosuppression	immunosuppression	NOUN
ajbspi-134509	131	7	involves	involve	VERB
ajbspi-134509	131	8	the	the	DET
ajbspi-134509	131	9	upregulation	upregulation	NOUN
ajbspi-134509	131	10	of	of	ADP
ajbspi-134509	131	11	cd39	cd39	PROPN
ajbspi-134509	131	12	and	and	CCONJ
ajbspi-134509	131	13	cd73	cd73	PROPN
ajbspi-134509	131	14	on	on	ADP
ajbspi-134509	131	15	their	their	PRON
ajbspi-134509	131	16	surface	surface	NOUN
ajbspi-134509	131	17	,	,	PUNCT
ajbspi-134509	131	18	leading	lead	VERB
ajbspi-134509	131	19	to	to	ADP
ajbspi-134509	131	20	increased	increase	VERB
ajbspi-134509	131	21	adenosine	adenosine	NOUN
ajbspi-134509	131	22	production	production	NOUN
ajbspi-134509	131	23	[	[	X
ajbspi-134509	131	24	37	37	NUM
ajbspi-134509	131	25	,	,	PUNCT
ajbspi-134509	131	26	38	38	NUM
ajbspi-134509	131	27	,	,	PUNCT
ajbspi-134509	131	28	39	39	NUM
ajbspi-134509	131	29	,	,	PUNCT
ajbspi-134509	131	30	40	40	NUM
ajbspi-134509	131	31	]	]	PUNCT
ajbspi-134509	131	32	.	.	PUNCT
ajbspi-134509	132	1	this	this	DET
ajbspi-134509	132	2	adenosine	adenosine	NOUN
ajbspi-134509	132	3	then	then	ADV
ajbspi-134509	132	4	acts	act	VERB
ajbspi-134509	132	5	on	on	ADP
ajbspi-134509	132	6	t	t	NOUN
ajbspi-134509	132	7	cells	cell	NOUN
ajbspi-134509	132	8	and	and	CCONJ
ajbspi-134509	132	9	other	other	ADJ
ajbspi-134509	132	10	immune	immune	ADJ
ajbspi-134509	132	11	cells	cell	NOUN
ajbspi-134509	132	12	to	to	PART
ajbspi-134509	132	13	suppress	suppress	VERB
ajbspi-134509	132	14	anti	anti	ADJ
ajbspi-134509	132	15	-	-	ADJ
ajbspi-134509	132	16	tumor	tumor	ADJ
ajbspi-134509	132	17	or	or	CCONJ
ajbspi-134509	132	18	anti	anti	ADJ
ajbspi-134509	132	19	-	-	ADJ
ajbspi-134509	132	20	pathogen	pathogen	NOUN
ajbspi-134509	132	21	responses	response	NOUN
ajbspi-134509	132	22	[	[	X
ajbspi-134509	132	23	37	37	NUM
ajbspi-134509	132	24	,	,	PUNCT
ajbspi-134509	132	25	38	38	NUM
ajbspi-134509	132	26	,	,	PUNCT
ajbspi-134509	132	27	39	39	NUM
ajbspi-134509	132	28	,	,	PUNCT
ajbspi-134509	132	29	40	40	NUM
ajbspi-134509	132	30	]	]	PUNCT
ajbspi-134509	132	31	.	.	PUNCT
ajbspi-134509	133	1	the	the	DET
ajbspi-134509	133	2	upregulation	upregulation	NOUN
ajbspi-134509	133	3	of	of	ADP
ajbspi-134509	133	4	cd39	cd39	PROPN
ajbspi-134509	133	5	/	/	SYM
ajbspi-134509	133	6	cd73	cd73	PROPN
ajbspi-134509	133	7	on	on	ADP
ajbspi-134509	133	8	mdscs	mdsc	NOUN
ajbspi-134509	133	9	can	can	AUX
ajbspi-134509	133	10	be	be	AUX
ajbspi-134509	133	11	driven	drive	VERB
ajbspi-134509	133	12	by	by	ADP
ajbspi-134509	133	13	pathways	pathway	NOUN
ajbspi-134509	133	14	like	like	ADP
ajbspi-134509	133	15	tgf	tgf	PROPN
ajbspi-134509	133	16	-	-	PUNCT
ajbspi-134509	133	17	β	β	NOUN
ajbspi-134509	133	18	-	-	PUNCT
ajbspi-134509	133	19	mtor	mtor	NOUN
ajbspi-134509	133	20	-	-	PUNCT
ajbspi-134509	133	21	hif-1	hif-1	NOUN
ajbspi-134509	133	22	signaling	signal	VERB
ajbspi-134509	133	23	[	[	X
ajbspi-134509	133	24	37	37	NUM
ajbspi-134509	133	25	]	]	PUNCT
ajbspi-134509	133	26	.	.	PUNCT
ajbspi-134509	134	1	•	•	NUM
ajbspi-134509	134	2	mast	mast	NOUN
ajbspi-134509	134	3	cells	cell	NOUN
ajbspi-134509	134	4	:	:	PUNCT
ajbspi-134509	134	5	mast	mast	NOUN
ajbspi-134509	134	6	cells	cell	NOUN
ajbspi-134509	134	7	are	be	AUX
ajbspi-134509	134	8	critical	critical	ADJ
ajbspi-134509	134	9	effector	effector	NOUN
ajbspi-134509	134	10	cells	cell	NOUN
ajbspi-134509	134	11	in	in	ADP
ajbspi-134509	134	12	allergic	allergic	ADJ
ajbspi-134509	134	13	diseases	disease	NOUN
ajbspi-134509	134	14	and	and	CCONJ
ajbspi-134509	134	15	play	play	VERB
ajbspi-134509	134	16	roles	role	NOUN
ajbspi-134509	134	17	in	in	ADP
ajbspi-134509	134	18	innate	innate	ADJ
ajbspi-134509	134	19	immunity	immunity	NOUN
ajbspi-134509	134	20	.	.	PUNCT
ajbspi-134509	135	1	adenosine	adenosine	NOUN
ajbspi-134509	135	2	signaling	signal	VERB
ajbspi-134509	135	3	,	,	PUNCT
ajbspi-134509	135	4	particularly	particularly	ADV
ajbspi-134509	135	5	through	through	ADP
ajbspi-134509	135	6	a2b	a2b	PROPN
ajbspi-134509	135	7	and	and	CCONJ
ajbspi-134509	135	8	a3	a3	NOUN
ajbspi-134509	135	9	receptors	receptor	NOUN
ajbspi-134509	135	10	,	,	PUNCT
ajbspi-134509	135	11	is	be	AUX
ajbspi-134509	135	12	involved	involve	VERB
ajbspi-134509	135	13	in	in	ADP
ajbspi-134509	135	14	modulating	modulate	VERB
ajbspi-134509	135	15	mast	mast	NOUN
ajbspi-134509	135	16	cell	cell	NOUN
ajbspi-134509	135	17	function	function	NOUN
ajbspi-134509	135	18	and	and	CCONJ
ajbspi-134509	135	19	allergic	allergic	ADJ
ajbspi-134509	135	20	responses	response	NOUN
ajbspi-134509	135	21	[	[	X
ajbspi-134509	135	22	33	33	NUM
ajbspi-134509	135	23	,	,	PUNCT
ajbspi-134509	135	24	34	34	NUM
ajbspi-134509	135	25	]	]	PUNCT
ajbspi-134509	135	26	.	.	PUNCT
ajbspi-134509	136	1	purinergic	purinergic	NOUN
ajbspi-134509	136	2	regulation	regulation	NOUN
ajbspi-134509	136	3	,	,	PUNCT
ajbspi-134509	136	4	including	include	VERB
ajbspi-134509	136	5	p2x4	p2x4	NOUN
ajbspi-134509	136	6	receptor	receptor	NOUN
ajbspi-134509	136	7	-	-	PUNCT
ajbspi-134509	136	8	mediated	mediate	VERB
ajbspi-134509	136	9	enhancement	enhancement	NOUN
ajbspi-134509	136	10	,	,	PUNCT
ajbspi-134509	136	11	can	can	AUX
ajbspi-134509	136	12	impact	impact	VERB
ajbspi-134509	136	13	allergic	allergic	ADJ
ajbspi-134509	136	14	responses	response	NOUN
ajbspi-134509	136	15	[	[	X
ajbspi-134509	136	16	34	34	NUM
ajbspi-134509	136	17	]	]	PUNCT
ajbspi-134509	136	18	.	.	PUNCT
ajbspi-134509	137	1	host	host	NOUN
ajbspi-134509	137	2	homeostasis	homeostasis	NOUN
ajbspi-134509	137	3	disruption	disruption	NOUN
ajbspi-134509	137	4	in	in	ADP
ajbspi-134509	137	5	c.	c.	PROPN
ajbspi-134509	137	6	difficile	difficile	PROPN
ajbspi-134509	137	7	infection	infection	NOUN
ajbspi-134509	137	8	clostridioides	clostridioide	NOUN
ajbspi-134509	137	9	difficile	difficile	VERB
ajbspi-134509	137	10	infection	infection	NOUN
ajbspi-134509	137	11	is	be	AUX
ajbspi-134509	137	12	characterized	characterize	VERB
ajbspi-134509	137	13	by	by	ADP
ajbspi-134509	137	14	a	a	DET
ajbspi-134509	137	15	severe	severe	ADJ
ajbspi-134509	137	16	inflammatory	inflammatory	ADJ
ajbspi-134509	137	17	response	response	NOUN
ajbspi-134509	137	18	in	in	ADP
ajbspi-134509	137	19	the	the	DET
ajbspi-134509	137	20	gut	gut	NOUN
ajbspi-134509	137	21	,	,	PUNCT
ajbspi-134509	137	22	leading	lead	VERB
ajbspi-134509	137	23	to	to	ADP
ajbspi-134509	137	24	significant	significant	ADJ
ajbspi-134509	137	25	tissue	tissue	NOUN
ajbspi-134509	137	26	damage	damage	NOUN
ajbspi-134509	137	27	and	and	CCONJ
ajbspi-134509	137	28	disruption	disruption	NOUN
ajbspi-134509	137	29	of	of	ADP
ajbspi-134509	137	30	the	the	DET
ajbspi-134509	137	31	intestinal	intestinal	ADJ
ajbspi-134509	137	32	epithelial	epithelial	ADJ
ajbspi-134509	137	33	barrier	barrier	NOUN
ajbspi-134509	137	34	.	.	PUNCT
ajbspi-134509	138	1	this	this	DET
ajbspi-134509	138	2	environment	environment	NOUN
ajbspi-134509	138	3	is	be	AUX
ajbspi-134509	138	4	highly	highly	ADV
ajbspi-134509	138	5	conducive	conducive	ADJ
ajbspi-134509	138	6	to	to	ADP
ajbspi-134509	138	7	the	the	DET
ajbspi-134509	138	8	release	release	NOUN
ajbspi-134509	138	9	of	of	ADP
ajbspi-134509	138	10	damps	damp	NOUN
ajbspi-134509	138	11	,	,	PUNCT
ajbspi-134509	138	12	including	include	VERB
ajbspi-134509	138	13	atp	atp	PROPN
ajbspi-134509	138	14	,	,	PUNCT
ajbspi-134509	138	15	from	from	ADP
ajbspi-134509	138	16	damaged	damage	VERB
ajbspi-134509	138	17	host	host	NOUN
ajbspi-134509	138	18	cells	cell	NOUN
ajbspi-134509	138	19	[	[	X
ajbspi-134509	138	20	59	59	NUM
ajbspi-134509	138	21	,	,	PUNCT
ajbspi-134509	138	22	60	60	NUM
ajbspi-134509	138	23	,	,	PUNCT
ajbspi-134509	138	24	61	61	NUM
ajbspi-134509	138	25	,	,	PUNCT
ajbspi-134509	138	26	62	62	NUM
ajbspi-134509	138	27	,	,	PUNCT
ajbspi-134509	138	28	63	63	NUM
ajbspi-134509	138	29	,	,	PUNCT
ajbspi-134509	138	30	64	64	NUM
ajbspi-134509	138	31	,	,	PUNCT
ajbspi-134509	138	32	65	65	NUM
ajbspi-134509	138	33	,	,	PUNCT
ajbspi-134509	138	34	66	66	NUM
ajbspi-134509	138	35	]	]	PUNCT
ajbspi-134509	138	36	.	.	PUNCT
ajbspi-134509	139	1	the	the	DET
ajbspi-134509	139	2	potent	potent	ADJ
ajbspi-134509	139	3	toxins	toxin	NOUN
ajbspi-134509	139	4	produced	produce	VERB
ajbspi-134509	139	5	by	by	ADP
ajbspi-134509	139	6	c.	c.	PROPN
ajbspi-134509	139	7	difficile	difficile	PROPN
ajbspi-134509	139	8	,	,	PUNCT
ajbspi-134509	139	9	tcda	tcda	NOUN
ajbspi-134509	139	10	and	and	CCONJ
ajbspi-134509	139	11	tcdb	tcdb	NOUN
ajbspi-134509	139	12	,	,	PUNCT
ajbspi-134509	139	13	induce	induce	VERB
ajbspi-134509	139	14	actin	actin	NOUN
ajbspi-134509	139	15	cytoskeleton	cytoskeleton	NOUN
ajbspi-134509	139	16	disruption	disruption	NOUN
ajbspi-134509	139	17	,	,	PUNCT
ajbspi-134509	139	18	cell	cell	NOUN
ajbspi-134509	139	19	rounding	rounding	NOUN
ajbspi-134509	139	20	,	,	PUNCT
ajbspi-134509	139	21	and	and	CCONJ
ajbspi-134509	139	22	apoptosis	apoptosis	NOUN
ajbspi-134509	139	23	in	in	ADP
ajbspi-134509	139	24	intestinal	intestinal	ADJ
ajbspi-134509	139	25	epithelial	epithelial	ADJ
ajbspi-134509	139	26	cells	cell	NOUN
ajbspi-134509	139	27	,	,	PUNCT
ajbspi-134509	139	28	further	far	ADV
ajbspi-134509	139	29	contributing	contribute	VERB
ajbspi-134509	139	30	to	to	ADP
ajbspi-134509	139	31	cellular	cellular	ADJ
ajbspi-134509	139	32	stress	stress	NOUN
ajbspi-134509	139	33	and	and	CCONJ
ajbspi-134509	139	34	atp	atp	NOUN
ajbspi-134509	139	35	release	release	NOUN
ajbspi-134509	139	36	[	[	X
ajbspi-134509	139	37	reference	reference	NOUN
ajbspi-134509	139	38	to	to	ADP
ajbspi-134509	139	39	c.	c.	NOUN
ajbspi-134509	139	40	difficile	difficile	VERB
ajbspi-134509	139	41	toxins	toxin	NOUN
ajbspi-134509	139	42	and	and	CCONJ
ajbspi-134509	139	43	their	their	PRON
ajbspi-134509	139	44	effects	effect	NOUN
ajbspi-134509	139	45	,	,	PUNCT
ajbspi-134509	139	46	if	if	SCONJ
ajbspi-134509	139	47	available	available	ADJ
ajbspi-134509	139	48	in	in	ADP
ajbspi-134509	139	49	provided	provide	VERB
ajbspi-134509	139	50	refs	ref	NOUN
ajbspi-134509	139	51	,	,	PUNCT
ajbspi-134509	139	52	otherwise	otherwise	ADV
ajbspi-134509	139	53	general	general	ADJ
ajbspi-134509	139	54	knowledge	knowledge	NOUN
ajbspi-134509	139	55	]	]	PUNCT
ajbspi-134509	139	56	.	.	PUNCT
ajbspi-134509	140	1	the	the	DET
ajbspi-134509	140	2	surge	surge	NOUN
ajbspi-134509	140	3	in	in	ADP
ajbspi-134509	140	4	extracellular	extracellular	ADJ
ajbspi-134509	140	5	atp	atp	NOUN
ajbspi-134509	140	6	during	during	ADP
ajbspi-134509	140	7	cdi	cdi	PROPN
ajbspi-134509	140	8	would	would	AUX
ajbspi-134509	140	9	initially	initially	ADV
ajbspi-134509	140	10	trigger	trigger	VERB
ajbspi-134509	140	11	pro	pro	ADJ
ajbspi-134509	140	12	-	-	ADJ
ajbspi-134509	140	13	inflammatory	inflammatory	ADJ
ajbspi-134509	140	14	responses	response	NOUN
ajbspi-134509	140	15	via	via	ADP
ajbspi-134509	140	16	p2x	p2x	NOUN
ajbspi-134509	140	17	and	and	CCONJ
ajbspi-134509	140	18	p2y	p2y	ADJ
ajbspi-134509	140	19	purinergic	purinergic	NOUN
ajbspi-134509	140	20	receptors	receptor	NOUN
ajbspi-134509	140	21	[	[	X
ajbspi-134509	140	22	59	59	NUM
ajbspi-134509	140	23	,	,	PUNCT
ajbspi-134509	140	24	60	60	NUM
ajbspi-134509	140	25	,	,	PUNCT
ajbspi-134509	140	26	61	61	NUM
ajbspi-134509	140	27	,	,	PUNCT
ajbspi-134509	140	28	62	62	NUM
ajbspi-134509	140	29	,	,	PUNCT
ajbspi-134509	140	30	63	63	NUM
ajbspi-134509	140	31	,	,	PUNCT
ajbspi-134509	140	32	64	64	NUM
ajbspi-134509	140	33	,	,	PUNCT
ajbspi-134509	140	34	65	65	NUM
ajbspi-134509	140	35	,	,	PUNCT
ajbspi-134509	140	36	66	66	NUM
ajbspi-134509	140	37	]	]	PUNCT
ajbspi-134509	140	38	.	.	PUNCT
ajbspi-134509	141	1	however	however	ADV
ajbspi-134509	141	2	,	,	PUNCT
ajbspi-134509	141	3	the	the	DET
ajbspi-134509	141	4	subsequent	subsequent	ADJ
ajbspi-134509	141	5	rapid	rapid	ADJ
ajbspi-134509	141	6	conversion	conversion	NOUN
ajbspi-134509	141	7	of	of	ADP
ajbspi-134509	141	8	this	this	DET
ajbspi-134509	141	9	atp	atp	NOUN
ajbspi-134509	141	10	to	to	PART
ajbspi-134509	141	11	adenosine	adenosine	VERB
ajbspi-134509	141	12	by	by	ADP
ajbspi-134509	141	13	ectonucleotidases	ectonucleotidase	NOUN
ajbspi-134509	141	14	(	(	PUNCT
ajbspi-134509	141	15	cd39	cd39	PROPN
ajbspi-134509	141	16	and	and	CCONJ
ajbspi-134509	141	17	cd73	cd73	PROPN
ajbspi-134509	141	18	)	)	PUNCT
ajbspi-134509	141	19	,	,	PUNCT
ajbspi-134509	141	20	which	which	PRON
ajbspi-134509	141	21	are	be	AUX
ajbspi-134509	141	22	upregulated	upregulate	VERB
ajbspi-134509	141	23	in	in	ADP
ajbspi-134509	141	24	inflammatory	inflammatory	ADJ
ajbspi-134509	141	25	conditions	condition	NOUN
ajbspi-134509	141	26	,	,	PUNCT
ajbspi-134509	141	27	could	could	AUX
ajbspi-134509	141	28	create	create	VERB
ajbspi-134509	141	29	a	a	DET
ajbspi-134509	141	30	local	local	ADJ
ajbspi-134509	141	31	immunosuppressive	immunosuppressive	ADJ
ajbspi-134509	141	32	microenvironment	microenvironment	NOUN
ajbspi-134509	141	33	[	[	X
ajbspi-134509	141	34	13	13	NUM
ajbspi-134509	141	35	,	,	PUNCT
ajbspi-134509	141	36	16	16	NUM
ajbspi-134509	141	37	,	,	PUNCT
ajbspi-134509	141	38	31	31	NUM
ajbspi-134509	141	39	,	,	PUNCT
ajbspi-134509	141	40	32	32	NUM
ajbspi-134509	141	41	]	]	PUNCT
ajbspi-134509	141	42	.	.	PUNCT
ajbspi-134509	142	1	hypothesized	hypothesized	ADJ
ajbspi-134509	142	2	c.	c.	NOUN
ajbspi-134509	142	3	difficile	difficile	NOUN
ajbspi-134509	142	4	manipulation	manipulation	NOUN
ajbspi-134509	142	5	of	of	ADP
ajbspi-134509	142	6	adenosine	adenosine	NOUN
ajbspi-134509	142	7	given	give	VERB
ajbspi-134509	142	8	the	the	DET
ajbspi-134509	142	9	established	establish	VERB
ajbspi-134509	142	10	immunomodulatory	immunomodulatory	ADJ
ajbspi-134509	142	11	roles	role	NOUN
ajbspi-134509	142	12	of	of	ADP
ajbspi-134509	142	13	adenosine	adenosine	NOUN
ajbspi-134509	142	14	,	,	PUNCT
ajbspi-134509	142	15	it	it	PRON
ajbspi-134509	142	16	is	be	AUX
ajbspi-134509	142	17	highly	highly	ADV
ajbspi-134509	142	18	plausible	plausible	ADJ
ajbspi-134509	142	19	that	that	SCONJ
ajbspi-134509	142	20	c.	c.	NOUN
ajbspi-134509	142	21	difficile	difficile	PROPN
ajbspi-134509	142	22	has	have	AUX
ajbspi-134509	142	23	evolved	evolve	VERB
ajbspi-134509	142	24	,	,	PUNCT
ajbspi-134509	142	25	or	or	CCONJ
ajbspi-134509	142	26	inadvertently	inadvertently	ADV
ajbspi-134509	142	27	benefits	benefit	NOUN
ajbspi-134509	142	28	from	from	ADP
ajbspi-134509	142	29	,	,	PUNCT
ajbspi-134509	142	30	mechanisms	mechanism	NOUN
ajbspi-134509	142	31	that	that	PRON
ajbspi-134509	142	32	manipulate	manipulate	VERB
ajbspi-134509	142	33	the	the	DET
ajbspi-134509	142	34	host	host	NOUN
ajbspi-134509	142	35	's	's	PART
ajbspi-134509	142	36	adenosine	adenosine	ADJ
ajbspi-134509	142	37	system	system	NOUN
ajbspi-134509	142	38	to	to	ADP
ajbspi-134509	142	39	its	its	PRON
ajbspi-134509	142	40	advantage	advantage	NOUN
ajbspi-134509	142	41	.	.	PUNCT
ajbspi-134509	143	1	the	the	DET
ajbspi-134509	143	2	bacterium	bacterium	NOUN
ajbspi-134509	143	3	thrives	thrive	VERB
ajbspi-134509	143	4	in	in	ADP
ajbspi-134509	143	5	an	an	DET
ajbspi-134509	143	6	inflamed	inflame	VERB
ajbspi-134509	143	7	gut	gut	NOUN
ajbspi-134509	143	8	environment	environment	NOUN
ajbspi-134509	143	9	,	,	PUNCT
ajbspi-134509	143	10	and	and	CCONJ
ajbspi-134509	143	11	an	an	DET
ajbspi-134509	143	12	immunosuppressive	immunosuppressive	ADJ
ajbspi-134509	143	13	milieu	milieu	NOUN
ajbspi-134509	143	14	mediated	mediate	VERB
ajbspi-134509	143	15	by	by	ADP
ajbspi-134509	143	16	adenosine	adenosine	NOUN
ajbspi-134509	143	17	could	could	AUX
ajbspi-134509	143	18	facilitate	facilitate	VERB
ajbspi-134509	143	19	its	its	PRON
ajbspi-134509	143	20	colonization	colonization	NOUN
ajbspi-134509	143	21	,	,	PUNCT
ajbspi-134509	143	22	persistence	persistence	NOUN
ajbspi-134509	143	23	,	,	PUNCT
ajbspi-134509	143	24	and	and	CCONJ
ajbspi-134509	143	25	recurrence	recurrence	NOUN
ajbspi-134509	143	26	.	.	PUNCT
ajbspi-134509	144	1	several	several	ADJ
ajbspi-134509	144	2	potential	potential	ADJ
ajbspi-134509	144	3	mechanisms	mechanism	NOUN
ajbspi-134509	144	4	by	by	ADP
ajbspi-134509	144	5	which	which	PRON
ajbspi-134509	144	6	c.	c.	NOUN
ajbspi-134509	144	7	difficile	difficile	NOUN
ajbspi-134509	144	8	could	could	AUX
ajbspi-134509	144	9	influence	influence	VERB
ajbspi-134509	144	10	host	host	NOUN
ajbspi-134509	144	11	adenosine	adenosine	NOUN
ajbspi-134509	144	12	homeostasis	homeostasis	NOUN
ajbspi-134509	144	13	can	can	AUX
ajbspi-134509	144	14	be	be	AUX
ajbspi-134509	144	15	hypothesized	hypothesize	VERB
ajbspi-134509	144	16	:	:	PUNCT
ajbspi-134509	144	17	1	1	X
ajbspi-134509	144	18	.	.	X
ajbspi-134509	144	19	exploitation	exploitation	NOUN
ajbspi-134509	144	20	of	of	ADP
ajbspi-134509	144	21	host	host	NOUN
ajbspi-134509	144	22	cell	cell	NOUN
ajbspi-134509	144	23	death	death	NOUN
ajbspi-134509	144	24	and	and	CCONJ
ajbspi-134509	144	25	inflammation	inflammation	NOUN
ajbspi-134509	144	26	-	-	PUNCT
ajbspi-134509	144	27	induced	induce	VERB
ajbspi-134509	144	28	atp	atp	NOUN
ajbspi-134509	144	29	release	release	NOUN
ajbspi-134509	144	30	:	:	PUNCT
ajbspi-134509	144	31	the	the	DET
ajbspi-134509	144	32	primary	primary	ADJ
ajbspi-134509	144	33	mechanism	mechanism	NOUN
ajbspi-134509	144	34	would	would	AUX
ajbspi-134509	144	35	be	be	AUX
ajbspi-134509	144	36	indirect	indirect	ADJ
ajbspi-134509	144	37	.	.	PUNCT
ajbspi-134509	145	1	c.	c.	NOUN
ajbspi-134509	145	2	difficile	difficile	NOUN
ajbspi-134509	145	3	toxins	toxin	NOUN
ajbspi-134509	145	4	induce	induce	VERB
ajbspi-134509	145	5	significant	significant	ADJ
ajbspi-134509	145	6	host	host	NOUN
ajbspi-134509	145	7	cell	cell	NOUN
ajbspi-134509	145	8	damage	damage	NOUN
ajbspi-134509	145	9	and	and	CCONJ
ajbspi-134509	145	10	inflammation	inflammation	NOUN
ajbspi-134509	145	11	.	.	PUNCT
ajbspi-134509	146	1	this	this	DET
ajbspi-134509	146	2	cellular	cellular	ADJ
ajbspi-134509	146	3	distress	distress	NOUN
ajbspi-134509	146	4	leads	lead	VERB
ajbspi-134509	146	5	to	to	ADP
ajbspi-134509	146	6	a	a	DET
ajbspi-134509	146	7	substantial	substantial	ADJ
ajbspi-134509	146	8	release	release	NOUN
ajbspi-134509	146	9	of	of	ADP
ajbspi-134509	146	10	intracellular	intracellular	ADJ
ajbspi-134509	146	11	atp	atp	NOUN
ajbspi-134509	146	12	into	into	ADP
ajbspi-134509	146	13	the	the	DET
ajbspi-134509	146	14	extracellular	extracellular	ADJ
ajbspi-134509	146	15	space	space	NOUN
ajbspi-134509	146	16	,	,	PUNCT
ajbspi-134509	146	17	acting	act	VERB
ajbspi-134509	146	18	as	as	ADP
ajbspi-134509	146	19	a	a	DET
ajbspi-134509	146	20	damp	damp	NOUN
ajbspi-134509	146	21	[	[	X
ajbspi-134509	146	22	59	59	NUM
ajbspi-134509	146	23	,	,	PUNCT
ajbspi-134509	146	24	60	60	NUM
ajbspi-134509	146	25	,	,	PUNCT
ajbspi-134509	146	26	61	61	NUM
ajbspi-134509	146	27	,	,	PUNCT
ajbspi-134509	146	28	62	62	NUM
ajbspi-134509	146	29	,	,	PUNCT
ajbspi-134509	146	30	63	63	NUM
ajbspi-134509	146	31	,	,	PUNCT
ajbspi-134509	146	32	64	64	NUM
ajbspi-134509	146	33	,	,	PUNCT
ajbspi-134509	146	34	65	65	NUM
ajbspi-134509	146	35	,	,	PUNCT
ajbspi-134509	146	36	66	66	NUM
ajbspi-134509	146	37	]	]	PUNCT
ajbspi-134509	146	38	.	.	PUNCT
ajbspi-134509	147	1	the	the	DET
ajbspi-134509	147	2	host	host	NOUN
ajbspi-134509	147	3	's	's	PART
ajbspi-134509	147	4	own	own	ADJ
ajbspi-134509	147	5	protective	protective	ADJ
ajbspi-134509	147	6	mechanisms	mechanism	NOUN
ajbspi-134509	147	7	,	,	PUNCT
ajbspi-134509	147	8	designed	design	VERB
ajbspi-134509	147	9	to	to	PART
ajbspi-134509	147	10	resolve	resolve	VERB
ajbspi-134509	147	11	inflammation	inflammation	NOUN
ajbspi-134509	147	12	,	,	PUNCT
ajbspi-134509	147	13	would	would	AUX
ajbspi-134509	147	14	then	then	ADV
ajbspi-134509	147	15	convert	convert	VERB
ajbspi-134509	147	16	this	this	DET
ajbspi-134509	147	17	proinflammatory	proinflammatory	ADJ
ajbspi-134509	147	18	atp	atp	NOUN
ajbspi-134509	147	19	into	into	ADP
ajbspi-134509	147	20	anti	anti	ADJ
ajbspi-134509	147	21	-	-	ADJ
ajbspi-134509	147	22	inflammatory	inflammatory	ADJ
ajbspi-134509	147	23	adenosine	adenosine	NOUN
ajbspi-134509	147	24	via	via	ADP
ajbspi-134509	147	25	cd39	cd39	PROPN
ajbspi-134509	147	26	and	and	CCONJ
ajbspi-134509	147	27	cd73	cd73	PROPN
ajbspi-134509	147	28	[	[	X
ajbspi-134509	147	29	13	13	NUM
ajbspi-134509	147	30	,	,	PUNCT
ajbspi-134509	147	31	16	16	NUM
ajbspi-134509	147	32	,	,	PUNCT
ajbspi-134509	147	33	31	31	NUM
ajbspi-134509	147	34	,	,	PUNCT
ajbspi-134509	147	35	32	32	NUM
ajbspi-134509	147	36	]	]	PUNCT
ajbspi-134509	147	37	.	.	PUNCT
ajbspi-134509	148	1	by	by	ADP
ajbspi-134509	148	2	inducing	induce	VERB
ajbspi-134509	148	3	widespread	widespread	ADJ
ajbspi-134509	148	4	cellular	cellular	ADJ
ajbspi-134509	148	5	damage	damage	NOUN
ajbspi-134509	148	6	,	,	PUNCT
ajbspi-134509	148	7	c.	c.	NOUN
ajbspi-134509	148	8	difficile	difficile	VERB
ajbspi-134509	148	9	effectively	effectively	ADV
ajbspi-134509	148	10	"	"	PUNCT
ajbspi-134509	148	11	primes	prime	NOUN
ajbspi-134509	148	12	"	"	PUNCT
ajbspi-134509	148	13	the	the	DET
ajbspi-134509	148	14	environment	environment	NOUN
ajbspi-134509	148	15	for	for	ADP
ajbspi-134509	148	16	adenosine	adenosine	NOUN
ajbspi-134509	148	17	generation	generation	NOUN
ajbspi-134509	148	18	,	,	PUNCT
ajbspi-134509	148	19	which	which	PRON
ajbspi-134509	148	20	then	then	ADV
ajbspi-134509	148	21	suppresses	suppress	VERB
ajbspi-134509	148	22	the	the	DET
ajbspi-134509	148	23	very	very	ADV
ajbspi-134509	148	24	immune	immune	ADJ
ajbspi-134509	148	25	responses	response	NOUN
ajbspi-134509	148	26	that	that	PRON
ajbspi-134509	148	27	would	would	AUX
ajbspi-134509	148	28	clear	clear	VERB
ajbspi-134509	148	29	the	the	DET
ajbspi-134509	148	30	infection	infection	NOUN
ajbspi-134509	148	31	.	.	PUNCT
ajbspi-134509	149	1	2	2	X
ajbspi-134509	149	2	.	.	X
ajbspi-134509	149	3	modulation	modulation	NOUN
ajbspi-134509	149	4	of	of	ADP
ajbspi-134509	149	5	host	host	NOUN
ajbspi-134509	149	6	ectoenzyme	ectoenzyme	NOUN
ajbspi-134509	149	7	expression	expression	NOUN
ajbspi-134509	149	8	/	/	SYM
ajbspi-134509	149	9	activity	activity	NOUN
ajbspi-134509	149	10	:	:	PUNCT
ajbspi-134509	149	11	while	while	SCONJ
ajbspi-134509	149	12	not	not	PART
ajbspi-134509	149	13	directly	directly	ADV
ajbspi-134509	149	14	shown	show	VERB
ajbspi-134509	149	15	in	in	ADP
ajbspi-134509	149	16	the	the	DET
ajbspi-134509	149	17	american	american	ADJ
ajbspi-134509	149	18	journal	journal	PROPN
ajbspi-134509	149	19	of	of	ADP
ajbspi-134509	149	20	applied	apply	VERB
ajbspi-134509	149	21	science	science	NOUN
ajbspi-134509	149	22	and	and	CCONJ
ajbspi-134509	149	23	technology	technology	NOUN
ajbspi-134509	149	24	6	6	NUM
ajbspi-134509	149	25	https://theusajournals.com/index.php/ajast	https://theusajournals.com/index.php/ajast	NOUN
ajbspi-134509	149	26	american	american	PROPN
ajbspi-134509	149	27	journal	journal	PROPN
ajbspi-134509	149	28	of	of	ADP
ajbspi-134509	149	29	applied	apply	VERB
ajbspi-134509	149	30	science	science	NOUN
ajbspi-134509	149	31	and	and	CCONJ
ajbspi-134509	149	32	technology	technology	NOUN
ajbspi-134509	149	33	(	(	PUNCT
ajbspi-134509	149	34	issn	issn	PROPN
ajbspi-134509	149	35	:	:	PUNCT
ajbspi-134509	149	36	2771	2771	NUM
ajbspi-134509	149	37	-	-	SYM
ajbspi-134509	149	38	2745	2745	NUM
ajbspi-134509	149	39	)	)	PUNCT
ajbspi-134509	149	40	provided	provide	VERB
ajbspi-134509	149	41	references	reference	NOUN
ajbspi-134509	149	42	for	for	ADP
ajbspi-134509	149	43	c.	c.	PROPN
ajbspi-134509	149	44	difficile	difficile	PROPN
ajbspi-134509	149	45	,	,	PUNCT
ajbspi-134509	149	46	other	other	ADJ
ajbspi-134509	149	47	pathogens	pathogen	NOUN
ajbspi-134509	149	48	are	be	AUX
ajbspi-134509	149	49	known	know	VERB
ajbspi-134509	149	50	to	to	PART
ajbspi-134509	149	51	influence	influence	VERB
ajbspi-134509	149	52	host	host	NOUN
ajbspi-134509	149	53	enzyme	enzyme	NOUN
ajbspi-134509	149	54	expression	expression	NOUN
ajbspi-134509	149	55	.	.	PUNCT
ajbspi-134509	150	1	it	it	PRON
ajbspi-134509	150	2	is	be	AUX
ajbspi-134509	150	3	conceivable	conceivable	ADJ
ajbspi-134509	150	4	that	that	SCONJ
ajbspi-134509	150	5	c.	c.	NOUN
ajbspi-134509	150	6	difficile	difficile	VERB
ajbspi-134509	150	7	or	or	CCONJ
ajbspi-134509	150	8	its	its	PRON
ajbspi-134509	150	9	toxins	toxin	NOUN
ajbspi-134509	150	10	could	could	AUX
ajbspi-134509	150	11	directly	directly	ADV
ajbspi-134509	150	12	or	or	CCONJ
ajbspi-134509	150	13	indirectly	indirectly	ADV
ajbspi-134509	150	14	upregulate	upregulate	VERB
ajbspi-134509	150	15	the	the	DET
ajbspi-134509	150	16	expression	expression	NOUN
ajbspi-134509	150	17	or	or	CCONJ
ajbspi-134509	150	18	activity	activity	NOUN
ajbspi-134509	150	19	of	of	ADP
ajbspi-134509	150	20	host	host	NOUN
ajbspi-134509	150	21	cd39	cd39	PROPN
ajbspi-134509	150	22	and/or	and/or	CCONJ
ajbspi-134509	150	23	cd73	cd73	PROPN
ajbspi-134509	150	24	on	on	ADP
ajbspi-134509	150	25	intestinal	intestinal	ADJ
ajbspi-134509	150	26	epithelial	epithelial	ADJ
ajbspi-134509	150	27	cells	cell	NOUN
ajbspi-134509	150	28	,	,	PUNCT
ajbspi-134509	150	29	immune	immune	ADJ
ajbspi-134509	150	30	cells	cell	NOUN
ajbspi-134509	150	31	(	(	PUNCT
ajbspi-134509	150	32	e.g.	e.g.	ADV
ajbspi-134509	150	33	,	,	PUNCT
ajbspi-134509	150	34	mdscs	mdsc	NOUN
ajbspi-134509	150	35	,	,	PUNCT
ajbspi-134509	150	36	tregs	treg	NOUN
ajbspi-134509	150	37	)	)	PUNCT
ajbspi-134509	150	38	,	,	PUNCT
ajbspi-134509	150	39	or	or	CCONJ
ajbspi-134509	150	40	stromal	stromal	ADJ
ajbspi-134509	150	41	cells	cell	NOUN
ajbspi-134509	150	42	in	in	ADP
ajbspi-134509	150	43	the	the	DET
ajbspi-134509	150	44	gut	gut	NOUN
ajbspi-134509	150	45	.	.	PUNCT
ajbspi-134509	151	1	for	for	ADP
ajbspi-134509	151	2	instance	instance	NOUN
ajbspi-134509	151	3	,	,	PUNCT
ajbspi-134509	151	4	wnt	wnt	PROPN
ajbspi-134509	151	5	and	and	CCONJ
ajbspi-134509	151	6	β	β	NOUN
ajbspi-134509	151	7	-	-	ADJ
ajbspi-134509	151	8	catenin	catenin	ADJ
ajbspi-134509	151	9	signaling	signaling	NOUN
ajbspi-134509	151	10	,	,	PUNCT
ajbspi-134509	151	11	which	which	PRON
ajbspi-134509	151	12	can	can	AUX
ajbspi-134509	151	13	be	be	AUX
ajbspi-134509	151	14	affected	affect	VERB
ajbspi-134509	151	15	by	by	ADP
ajbspi-134509	151	16	bacterial	bacterial	ADJ
ajbspi-134509	151	17	pathogens	pathogen	NOUN
ajbspi-134509	151	18	,	,	PUNCT
ajbspi-134509	151	19	are	be	AUX
ajbspi-134509	151	20	known	know	VERB
ajbspi-134509	151	21	to	to	PART
ajbspi-134509	151	22	target	target	VERB
ajbspi-134509	151	23	the	the	DET
ajbspi-134509	151	24	expression	expression	NOUN
ajbspi-134509	151	25	of	of	ADP
ajbspi-134509	151	26	ecto-5'-nucleotidase	ecto-5'-nucleotidase	NOUN
ajbspi-134509	151	27	(	(	PUNCT
ajbspi-134509	151	28	cd73	cd73	PROPN
ajbspi-134509	151	29	)	)	PUNCT
ajbspi-134509	152	1	[	[	X
ajbspi-134509	152	2	53	53	NUM
ajbspi-134509	152	3	]	]	PUNCT
ajbspi-134509	152	4	.	.	PUNCT
ajbspi-134509	153	1	an	an	DET
ajbspi-134509	153	2	increase	increase	NOUN
ajbspi-134509	153	3	in	in	ADP
ajbspi-134509	153	4	these	these	DET
ajbspi-134509	153	5	ectoenzymes	ectoenzyme	NOUN
ajbspi-134509	153	6	would	would	AUX
ajbspi-134509	153	7	lead	lead	VERB
ajbspi-134509	153	8	to	to	ADP
ajbspi-134509	153	9	enhanced	enhanced	ADJ
ajbspi-134509	153	10	conversion	conversion	NOUN
ajbspi-134509	153	11	of	of	ADP
ajbspi-134509	153	12	atp	atp	PROPN
ajbspi-134509	153	13	to	to	PART
ajbspi-134509	153	14	adenosine	adenosine	VERB
ajbspi-134509	153	15	,	,	PUNCT
ajbspi-134509	153	16	favoring	favor	VERB
ajbspi-134509	153	17	an	an	DET
ajbspi-134509	153	18	immunosuppressive	immunosuppressive	ADJ
ajbspi-134509	153	19	environment	environment	NOUN
ajbspi-134509	153	20	.	.	PUNCT
ajbspi-134509	154	1	3	3	X
ajbspi-134509	154	2	.	.	X
ajbspi-134509	154	3	bacterial	bacterial	ADJ
ajbspi-134509	154	4	production	production	NOUN
ajbspi-134509	154	5	of	of	ADP
ajbspi-134509	154	6	adenosine	adenosine	NOUN
ajbspi-134509	154	7	-	-	PUNCT
ajbspi-134509	154	8	modulating	modulate	VERB
ajbspi-134509	154	9	enzymes	enzyme	NOUN
ajbspi-134509	154	10	:	:	PUNCT
ajbspi-134509	154	11	some	some	DET
ajbspi-134509	154	12	bacteria	bacteria	NOUN
ajbspi-134509	154	13	possess	possess	VERB
ajbspi-134509	154	14	their	their	PRON
ajbspi-134509	154	15	own	own	ADJ
ajbspi-134509	154	16	ectonucleotidases	ectonucleotidase	NOUN
ajbspi-134509	154	17	or	or	CCONJ
ajbspi-134509	154	18	enzymes	enzyme	NOUN
ajbspi-134509	154	19	that	that	PRON
ajbspi-134509	154	20	can	can	AUX
ajbspi-134509	154	21	directly	directly	ADV
ajbspi-134509	154	22	or	or	CCONJ
ajbspi-134509	154	23	indirectly	indirectly	ADV
ajbspi-134509	154	24	contribute	contribute	VERB
ajbspi-134509	154	25	to	to	ADP
ajbspi-134509	154	26	the	the	DET
ajbspi-134509	154	27	extracellular	extracellular	ADJ
ajbspi-134509	154	28	adenosine	adenosine	NOUN
ajbspi-134509	154	29	pool	pool	NOUN
ajbspi-134509	154	30	.	.	PUNCT
ajbspi-134509	155	1	while	while	SCONJ
ajbspi-134509	155	2	specific	specific	ADJ
ajbspi-134509	155	3	evidence	evidence	NOUN
ajbspi-134509	155	4	for	for	ADP
ajbspi-134509	155	5	c.	c.	NOUN
ajbspi-134509	155	6	difficile	difficile	NOUN
ajbspi-134509	155	7	is	be	AUX
ajbspi-134509	155	8	not	not	PART
ajbspi-134509	155	9	in	in	ADP
ajbspi-134509	155	10	the	the	DET
ajbspi-134509	155	11	provided	provide	VERB
ajbspi-134509	155	12	references	reference	NOUN
ajbspi-134509	155	13	,	,	PUNCT
ajbspi-134509	155	14	this	this	PRON
ajbspi-134509	155	15	represents	represent	VERB
ajbspi-134509	155	16	a	a	DET
ajbspi-134509	155	17	potential	potential	ADJ
ajbspi-134509	155	18	direct	direct	ADJ
ajbspi-134509	155	19	manipulation	manipulation	NOUN
ajbspi-134509	155	20	strategy	strategy	NOUN
ajbspi-134509	155	21	.	.	PUNCT
ajbspi-134509	156	1	for	for	ADP
ajbspi-134509	156	2	example	example	NOUN
ajbspi-134509	156	3	,	,	PUNCT
ajbspi-134509	156	4	some	some	DET
ajbspi-134509	156	5	bacteria	bacteria	NOUN
ajbspi-134509	156	6	might	might	AUX
ajbspi-134509	156	7	release	release	VERB
ajbspi-134509	156	8	enzymes	enzyme	NOUN
ajbspi-134509	156	9	that	that	PRON
ajbspi-134509	156	10	degrade	degrade	VERB
ajbspi-134509	156	11	host	host	NOUN
ajbspi-134509	156	12	atp	atp	NOUN
ajbspi-134509	156	13	or	or	CCONJ
ajbspi-134509	156	14	amp	amp	PROPN
ajbspi-134509	156	15	,	,	PUNCT
ajbspi-134509	156	16	leading	lead	VERB
ajbspi-134509	156	17	to	to	ADP
ajbspi-134509	156	18	adenosine	adenosine	VERB
ajbspi-134509	156	19	accumulation	accumulation	NOUN
ajbspi-134509	156	20	.	.	PUNCT
ajbspi-134509	157	1	4	4	X
ajbspi-134509	157	2	.	.	X
ajbspi-134509	157	3	impact	impact	NOUN
ajbspi-134509	157	4	on	on	ADP
ajbspi-134509	157	5	gut	gut	NOUN
ajbspi-134509	157	6	immunity	immunity	NOUN
ajbspi-134509	157	7	and	and	CCONJ
ajbspi-134509	157	8	disease	disease	NOUN
ajbspi-134509	157	9	progression	progression	NOUN
ajbspi-134509	157	10	:	:	PUNCT
ajbspi-134509	157	11	this	this	DET
ajbspi-134509	157	12	enhanced	enhanced	ADJ
ajbspi-134509	157	13	adenosine	adenosine	NOUN
ajbspi-134509	157	14	production	production	NOUN
ajbspi-134509	157	15	in	in	ADP
ajbspi-134509	157	16	the	the	DET
ajbspi-134509	157	17	gut	gut	NOUN
ajbspi-134509	157	18	microenvironment	microenvironment	NOUN
ajbspi-134509	157	19	during	during	ADP
ajbspi-134509	157	20	cdi	cdi	PROPN
ajbspi-134509	157	21	could	could	AUX
ajbspi-134509	157	22	profoundly	profoundly	ADV
ajbspi-134509	157	23	suppress	suppress	VERB
ajbspi-134509	157	24	local	local	ADJ
ajbspi-134509	157	25	immune	immune	ADJ
ajbspi-134509	157	26	responses	response	NOUN
ajbspi-134509	157	27	:	:	PUNCT
ajbspi-134509	157	28	o	o	NOUN
ajbspi-134509	157	29	reduced	reduce	VERB
ajbspi-134509	157	30	neutrophil	neutrophil	ADJ
ajbspi-134509	157	31	recruitment	recruitment	NOUN
ajbspi-134509	157	32	and	and	CCONJ
ajbspi-134509	157	33	function	function	NOUN
ajbspi-134509	157	34	:	:	PUNCT
ajbspi-134509	157	35	high	high	ADJ
ajbspi-134509	157	36	adenosine	adenosine	NOUN
ajbspi-134509	157	37	levels	level	NOUN
ajbspi-134509	157	38	would	would	AUX
ajbspi-134509	157	39	inhibit	inhibit	VERB
ajbspi-134509	157	40	neutrophil	neutrophil	ADJ
ajbspi-134509	157	41	infiltration	infiltration	NOUN
ajbspi-134509	157	42	and	and	CCONJ
ajbspi-134509	157	43	activation	activation	NOUN
ajbspi-134509	157	44	[	[	X
ajbspi-134509	157	45	18	18	NUM
ajbspi-134509	157	46	,	,	PUNCT
ajbspi-134509	157	47	19	19	NUM
ajbspi-134509	157	48	,	,	PUNCT
ajbspi-134509	157	49	20	20	NUM
ajbspi-134509	157	50	]	]	PUNCT
ajbspi-134509	157	51	,	,	PUNCT
ajbspi-134509	157	52	weakening	weaken	VERB
ajbspi-134509	157	53	a	a	DET
ajbspi-134509	157	54	crucial	crucial	ADJ
ajbspi-134509	157	55	early	early	ADJ
ajbspi-134509	157	56	defense	defense	NOUN
ajbspi-134509	157	57	against	against	ADP
ajbspi-134509	157	58	bacterial	bacterial	ADJ
ajbspi-134509	157	59	pathogens	pathogen	NOUN
ajbspi-134509	157	60	.	.	PUNCT
ajbspi-134509	158	1	o	o	NOUN
ajbspi-134509	158	2	shift	shift	NOUN
ajbspi-134509	158	3	towards	towards	ADP
ajbspi-134509	158	4	anti	anti	ADJ
ajbspi-134509	158	5	-	-	ADJ
ajbspi-134509	158	6	inflammatory	inflammatory	ADJ
ajbspi-134509	158	7	macrophages	macrophage	NOUN
ajbspi-134509	158	8	:	:	PUNCT
ajbspi-134509	158	9	adenosine	adenosine	NOUN
ajbspi-134509	158	10	would	would	AUX
ajbspi-134509	158	11	promote	promote	VERB
ajbspi-134509	158	12	the	the	DET
ajbspi-134509	158	13	m2	m2	PROPN
ajbspi-134509	158	14	macrophage	macrophage	ADJ
ajbspi-134509	158	15	phenotype	phenotype	NOUN
ajbspi-134509	158	16	[	[	X
ajbspi-134509	158	17	23	23	NUM
ajbspi-134509	158	18	,	,	PUNCT
ajbspi-134509	158	19	24	24	NUM
ajbspi-134509	158	20	,	,	PUNCT
ajbspi-134509	158	21	26	26	NUM
ajbspi-134509	158	22	]	]	PUNCT
ajbspi-134509	158	23	,	,	PUNCT
ajbspi-134509	158	24	which	which	PRON
ajbspi-134509	158	25	,	,	PUNCT
ajbspi-134509	158	26	while	while	SCONJ
ajbspi-134509	158	27	beneficial	beneficial	ADJ
ajbspi-134509	158	28	for	for	ADP
ajbspi-134509	158	29	tissue	tissue	NOUN
ajbspi-134509	158	30	repair	repair	NOUN
ajbspi-134509	158	31	in	in	ADP
ajbspi-134509	158	32	general	general	ADJ
ajbspi-134509	158	33	,	,	PUNCT
ajbspi-134509	158	34	might	might	AUX
ajbspi-134509	158	35	dampen	dampen	VERB
ajbspi-134509	158	36	effective	effective	ADJ
ajbspi-134509	158	37	bacterial	bacterial	ADJ
ajbspi-134509	158	38	clearance	clearance	NOUN
ajbspi-134509	158	39	in	in	ADP
ajbspi-134509	158	40	the	the	DET
ajbspi-134509	158	41	acute	acute	ADJ
ajbspi-134509	158	42	phase	phase	NOUN
ajbspi-134509	158	43	of	of	ADP
ajbspi-134509	158	44	infection	infection	NOUN
ajbspi-134509	158	45	.	.	PUNCT
ajbspi-134509	159	1	o	o	PROPN
ajbspi-134509	159	2	suppressed	suppress	VERB
ajbspi-134509	159	3	t	t	NOUN
ajbspi-134509	159	4	cell	cell	NOUN
ajbspi-134509	159	5	responses	response	NOUN
ajbspi-134509	159	6	:	:	PUNCT
ajbspi-134509	159	7	adenosine	adenosine	NOUN
ajbspi-134509	159	8	's	's	PART
ajbspi-134509	159	9	inhibitory	inhibitory	ADJ
ajbspi-134509	159	10	effects	effect	NOUN
ajbspi-134509	159	11	on	on	ADP
ajbspi-134509	159	12	effector	effector	NOUN
ajbspi-134509	159	13	t	t	PROPN
ajbspi-134509	159	14	cells	cell	NOUN
ajbspi-134509	159	15	(	(	PUNCT
ajbspi-134509	159	16	th1	th1	PROPN
ajbspi-134509	159	17	,	,	PUNCT
ajbspi-134509	159	18	cd8	cd8	PROPN
ajbspi-134509	159	19	+	+	PROPN
ajbspi-134509	159	20	t	t	NOUN
ajbspi-134509	159	21	cells	cell	NOUN
ajbspi-134509	159	22	)	)	PUNCT
ajbspi-134509	160	1	[	[	X
ajbspi-134509	160	2	33	33	NUM
ajbspi-134509	160	3	,	,	PUNCT
ajbspi-134509	160	4	34	34	NUM
ajbspi-134509	160	5	,	,	PUNCT
ajbspi-134509	160	6	35	35	NUM
ajbspi-134509	160	7	,	,	PUNCT
ajbspi-134509	160	8	51	51	NUM
ajbspi-134509	160	9	]	]	PUNCT
ajbspi-134509	160	10	and	and	CCONJ
ajbspi-134509	160	11	promotion	promotion	NOUN
ajbspi-134509	160	12	of	of	ADP
ajbspi-134509	160	13	tregs	treg	NOUN
ajbspi-134509	160	14	[	[	X
ajbspi-134509	160	15	50	50	NUM
ajbspi-134509	160	16	,	,	PUNCT
ajbspi-134509	160	17	51	51	NUM
ajbspi-134509	160	18	]	]	PUNCT
ajbspi-134509	160	19	would	would	AUX
ajbspi-134509	160	20	create	create	VERB
ajbspi-134509	160	21	an	an	DET
ajbspi-134509	160	22	immune	immune	ADJ
ajbspi-134509	160	23	-	-	PUNCT
ajbspi-134509	160	24	tolerant	tolerant	ADJ
ajbspi-134509	160	25	environment	environment	NOUN
ajbspi-134509	160	26	,	,	PUNCT
ajbspi-134509	160	27	potentially	potentially	ADV
ajbspi-134509	160	28	allowing	allow	VERB
ajbspi-134509	160	29	c.	c.	NOUN
ajbspi-134509	160	30	difficile	difficile	VERB
ajbspi-134509	160	31	to	to	PART
ajbspi-134509	160	32	persist	persist	VERB
ajbspi-134509	160	33	and	and	CCONJ
ajbspi-134509	160	34	colonize	colonize	VERB
ajbspi-134509	160	35	more	more	ADV
ajbspi-134509	160	36	effectively	effectively	ADV
ajbspi-134509	160	37	.	.	PUNCT
ajbspi-134509	161	1	this	this	PRON
ajbspi-134509	161	2	could	could	AUX
ajbspi-134509	161	3	contribute	contribute	VERB
ajbspi-134509	161	4	to	to	ADP
ajbspi-134509	161	5	the	the	DET
ajbspi-134509	161	6	t	t	NOUN
ajbspi-134509	161	7	cell	cell	NOUN
ajbspi-134509	161	8	exhaustion	exhaustion	NOUN
ajbspi-134509	161	9	observed	observe	VERB
ajbspi-134509	161	10	in	in	ADP
ajbspi-134509	161	11	chronic	chronic	ADJ
ajbspi-134509	161	12	inflammatory	inflammatory	ADJ
ajbspi-134509	161	13	states	state	NOUN
ajbspi-134509	161	14	[	[	X
ajbspi-134509	161	15	52	52	NUM
ajbspi-134509	161	16	,	,	PUNCT
ajbspi-134509	161	17	53	53	NUM
ajbspi-134509	161	18	]	]	PUNCT
ajbspi-134509	161	19	.	.	PUNCT
ajbspi-134509	162	1	o	o	PROPN
ajbspi-134509	162	2	dampened	dampen	VERB
ajbspi-134509	162	3	dendritic	dendritic	ADJ
ajbspi-134509	162	4	cell	cell	NOUN
ajbspi-134509	162	5	activation	activation	NOUN
ajbspi-134509	162	6	:	:	PUNCT
ajbspi-134509	162	7	impaired	impair	VERB
ajbspi-134509	162	8	dc	dc	PROPN
ajbspi-134509	162	9	maturation	maturation	NOUN
ajbspi-134509	162	10	and	and	CCONJ
ajbspi-134509	162	11	t	t	NOUN
ajbspi-134509	162	12	cell	cell	NOUN
ajbspi-134509	162	13	stimulatory	stimulatory	ADJ
ajbspi-134509	162	14	capacity	capacity	NOUN
ajbspi-134509	162	15	[	[	X
ajbspi-134509	162	16	29	29	NUM
ajbspi-134509	162	17	,	,	PUNCT
ajbspi-134509	162	18	30	30	NUM
ajbspi-134509	162	19	]	]	PUNCT
ajbspi-134509	162	20	would	would	AUX
ajbspi-134509	162	21	hinder	hinder	VERB
ajbspi-134509	162	22	the	the	DET
ajbspi-134509	162	23	development	development	NOUN
ajbspi-134509	162	24	of	of	ADP
ajbspi-134509	162	25	a	a	DET
ajbspi-134509	162	26	robust	robust	ADJ
ajbspi-134509	162	27	adaptive	adaptive	ADJ
ajbspi-134509	162	28	immune	immune	ADJ
ajbspi-134509	162	29	response	response	NOUN
ajbspi-134509	162	30	necessary	necessary	ADJ
ajbspi-134509	162	31	for	for	ADP
ajbspi-134509	162	32	long	long	ADJ
ajbspi-134509	162	33	-	-	PUNCT
ajbspi-134509	162	34	term	term	NOUN
ajbspi-134509	162	35	clearance	clearance	NOUN
ajbspi-134509	162	36	and	and	CCONJ
ajbspi-134509	162	37	protection	protection	NOUN
ajbspi-134509	162	38	against	against	ADP
ajbspi-134509	162	39	recurrence	recurrence	NOUN
ajbspi-134509	162	40	.	.	PUNCT
ajbspi-134509	163	1	the	the	DET
ajbspi-134509	163	2	overall	overall	ADJ
ajbspi-134509	163	3	consequence	consequence	NOUN
ajbspi-134509	163	4	of	of	ADP
ajbspi-134509	163	5	this	this	DET
ajbspi-134509	163	6	manipulation	manipulation	NOUN
ajbspi-134509	163	7	would	would	AUX
ajbspi-134509	163	8	be	be	AUX
ajbspi-134509	163	9	a	a	DET
ajbspi-134509	163	10	compromised	compromise	VERB
ajbspi-134509	163	11	host	host	NOUN
ajbspi-134509	163	12	immune	immune	ADJ
ajbspi-134509	163	13	response	response	NOUN
ajbspi-134509	163	14	,	,	PUNCT
ajbspi-134509	163	15	allowing	allow	VERB
ajbspi-134509	163	16	c.	c.	NOUN
ajbspi-134509	163	17	difficile	difficile	VERB
ajbspi-134509	163	18	to	to	PART
ajbspi-134509	163	19	establish	establish	VERB
ajbspi-134509	163	20	and	and	CCONJ
ajbspi-134509	163	21	maintain	maintain	VERB
ajbspi-134509	163	22	infection	infection	NOUN
ajbspi-134509	163	23	,	,	PUNCT
ajbspi-134509	163	24	potentially	potentially	ADV
ajbspi-134509	163	25	contributing	contribute	VERB
ajbspi-134509	163	26	to	to	ADP
ajbspi-134509	163	27	the	the	DET
ajbspi-134509	163	28	severity	severity	NOUN
ajbspi-134509	163	29	of	of	ADP
ajbspi-134509	163	30	colitis	colitis	NOUN
ajbspi-134509	163	31	and	and	CCONJ
ajbspi-134509	163	32	the	the	DET
ajbspi-134509	163	33	high	high	ADJ
ajbspi-134509	163	34	rates	rate	NOUN
ajbspi-134509	163	35	of	of	ADP
ajbspi-134509	163	36	recurrent	recurrent	ADJ
ajbspi-134509	163	37	cdi	cdi	PROPN
ajbspi-134509	163	38	.	.	PUNCT
ajbspi-134509	164	1	the	the	DET
ajbspi-134509	164	2	bacteria	bacteria	NOUN
ajbspi-134509	164	3	,	,	PUNCT
ajbspi-134509	164	4	by	by	ADP
ajbspi-134509	164	5	exploiting	exploit	VERB
ajbspi-134509	164	6	the	the	DET
ajbspi-134509	164	7	host	host	NOUN
ajbspi-134509	164	8	's	's	PART
ajbspi-134509	164	9	own	own	ADJ
ajbspi-134509	164	10	homeostatic	homeostatic	ADJ
ajbspi-134509	164	11	and	and	CCONJ
ajbspi-134509	164	12	anti	anti	ADJ
ajbspi-134509	164	13	-	-	ADJ
ajbspi-134509	164	14	inflammatory	inflammatory	ADJ
ajbspi-134509	164	15	mechanisms	mechanism	NOUN
ajbspi-134509	164	16	,	,	PUNCT
ajbspi-134509	164	17	effectively	effectively	ADV
ajbspi-134509	164	18	creates	create	VERB
ajbspi-134509	164	19	a	a	DET
ajbspi-134509	164	20	niche	niche	NOUN
ajbspi-134509	164	21	where	where	SCONJ
ajbspi-134509	164	22	it	it	PRON
ajbspi-134509	164	23	can	can	AUX
ajbspi-134509	164	24	evade	evade	VERB
ajbspi-134509	164	25	immune	immune	ADJ
ajbspi-134509	164	26	surveillance	surveillance	NOUN
ajbspi-134509	164	27	and	and	CCONJ
ajbspi-134509	164	28	thrive	thrive	VERB
ajbspi-134509	164	29	.	.	PUNCT
ajbspi-134509	165	1	discussion	discussion	NOUN
ajbspi-134509	165	2	the	the	DET
ajbspi-134509	165	3	detailed	detailed	ADJ
ajbspi-134509	165	4	exploration	exploration	NOUN
ajbspi-134509	165	5	of	of	ADP
ajbspi-134509	165	6	the	the	DET
ajbspi-134509	165	7	adenosine	adenosine	NOUN
ajbspi-134509	165	8	system	system	NOUN
ajbspi-134509	165	9	reveals	reveal	VERB
ajbspi-134509	165	10	a	a	DET
ajbspi-134509	165	11	sophisticated	sophisticated	ADJ
ajbspi-134509	165	12	regulatory	regulatory	ADJ
ajbspi-134509	165	13	network	network	NOUN
ajbspi-134509	165	14	critical	critical	ADJ
ajbspi-134509	165	15	for	for	ADP
ajbspi-134509	165	16	maintaining	maintain	VERB
ajbspi-134509	165	17	host	host	NOUN
ajbspi-134509	165	18	homeostasis	homeostasis	NOUN
ajbspi-134509	165	19	and	and	CCONJ
ajbspi-134509	165	20	modulating	modulate	VERB
ajbspi-134509	165	21	immune	immune	ADJ
ajbspi-134509	165	22	responses	response	NOUN
ajbspi-134509	165	23	.	.	PUNCT
ajbspi-134509	166	1	our	our	PRON
ajbspi-134509	166	2	synthesis	synthesis	NOUN
ajbspi-134509	166	3	highlights	highlight	NOUN
ajbspi-134509	166	4	how	how	SCONJ
ajbspi-134509	166	5	this	this	DET
ajbspi-134509	166	6	system	system	NOUN
ajbspi-134509	166	7	,	,	PUNCT
ajbspi-134509	166	8	designed	design	VERB
ajbspi-134509	166	9	to	to	PART
ajbspi-134509	166	10	protect	protect	VERB
ajbspi-134509	166	11	tissues	tissue	NOUN
ajbspi-134509	166	12	and	and	CCONJ
ajbspi-134509	166	13	resolve	resolve	VERB
ajbspi-134509	166	14	inflammation	inflammation	NOUN
ajbspi-134509	166	15	,	,	PUNCT
ajbspi-134509	166	16	could	could	AUX
ajbspi-134509	166	17	inadvertently	inadvertently	ADV
ajbspi-134509	166	18	become	become	VERB
ajbspi-134509	166	19	a	a	DET
ajbspi-134509	166	20	vulnerability	vulnerability	NOUN
ajbspi-134509	166	21	during	during	ADP
ajbspi-134509	166	22	infections	infection	NOUN
ajbspi-134509	166	23	characterized	characterize	VERB
ajbspi-134509	166	24	by	by	ADP
ajbspi-134509	166	25	significant	significant	ADJ
ajbspi-134509	166	26	tissue	tissue	NOUN
ajbspi-134509	166	27	damage	damage	NOUN
ajbspi-134509	166	28	and	and	CCONJ
ajbspi-134509	166	29	inflammation	inflammation	NOUN
ajbspi-134509	166	30	,	,	PUNCT
ajbspi-134509	166	31	such	such	ADJ
ajbspi-134509	166	32	as	as	ADP
ajbspi-134509	166	33	clostridioides	clostridioide	NOUN
ajbspi-134509	166	34	difficile	difficile	VERB
ajbspi-134509	166	35	infection	infection	NOUN
ajbspi-134509	166	36	.	.	PUNCT
ajbspi-134509	167	1	the	the	DET
ajbspi-134509	167	2	interplay	interplay	NOUN
ajbspi-134509	167	3	between	between	ADP
ajbspi-134509	167	4	extracellular	extracellular	ADJ
ajbspi-134509	167	5	atp	atp	PROPN
ajbspi-134509	167	6	(	(	PUNCT
ajbspi-134509	167	7	a	a	DET
ajbspi-134509	167	8	pro	pro	ADJ
ajbspi-134509	167	9	-	-	ADJ
ajbspi-134509	167	10	inflammatory	inflammatory	ADJ
ajbspi-134509	167	11	damp	damp	NOUN
ajbspi-134509	167	12	)	)	PUNCT
ajbspi-134509	167	13	and	and	CCONJ
ajbspi-134509	167	14	its	its	PRON
ajbspi-134509	167	15	rapid	rapid	ADJ
ajbspi-134509	167	16	conversion	conversion	NOUN
ajbspi-134509	167	17	to	to	PART
ajbspi-134509	167	18	adenosine	adenosine	VERB
ajbspi-134509	167	19	(	(	PUNCT
ajbspi-134509	167	20	an	an	DET
ajbspi-134509	167	21	anti	anti	ADJ
ajbspi-134509	167	22	-	-	ADJ
ajbspi-134509	167	23	inflammatory	inflammatory	ADJ
ajbspi-134509	167	24	signal	signal	NOUN
ajbspi-134509	167	25	)	)	PUNCT
ajbspi-134509	167	26	by	by	ADP
ajbspi-134509	167	27	ectonucleotidases	ectonucleotidase	NOUN
ajbspi-134509	167	28	cd39	cd39	PROPN
ajbspi-134509	167	29	and	and	CCONJ
ajbspi-134509	167	30	cd73	cd73	PROPN
ajbspi-134509	167	31	[	[	X
ajbspi-134509	167	32	13	13	NUM
ajbspi-134509	167	33	,	,	PUNCT
ajbspi-134509	167	34	16	16	NUM
ajbspi-134509	167	35	,	,	PUNCT
ajbspi-134509	167	36	31	31	NUM
ajbspi-134509	167	37	,	,	PUNCT
ajbspi-134509	167	38	32	32	NUM
ajbspi-134509	167	39	,	,	PUNCT
ajbspi-134509	167	40	59	59	NUM
ajbspi-134509	167	41	,	,	PUNCT
ajbspi-134509	167	42	60	60	NUM
ajbspi-134509	167	43	,	,	PUNCT
ajbspi-134509	167	44	61	61	NUM
ajbspi-134509	167	45	,	,	PUNCT
ajbspi-134509	167	46	62	62	NUM
ajbspi-134509	167	47	,	,	PUNCT
ajbspi-134509	167	48	63	63	NUM
ajbspi-134509	167	49	,	,	PUNCT
ajbspi-134509	167	50	64	64	NUM
ajbspi-134509	167	51	,	,	PUNCT
ajbspi-134509	167	52	65	65	NUM
ajbspi-134509	167	53	,	,	PUNCT
ajbspi-134509	167	54	66	66	NUM
ajbspi-134509	167	55	]	]	PUNCT
ajbspi-134509	167	56	is	be	AUX
ajbspi-134509	167	57	central	central	ADJ
ajbspi-134509	167	58	to	to	ADP
ajbspi-134509	167	59	this	this	DET
ajbspi-134509	167	60	dynamic	dynamic	NOUN
ajbspi-134509	167	61	.	.	PUNCT
ajbspi-134509	168	1	in	in	ADP
ajbspi-134509	168	2	the	the	DET
ajbspi-134509	168	3	context	context	NOUN
ajbspi-134509	168	4	of	of	ADP
ajbspi-134509	168	5	cdi	cdi	PROPN
ajbspi-134509	168	6	,	,	PUNCT
ajbspi-134509	168	7	the	the	DET
ajbspi-134509	168	8	severe	severe	ADJ
ajbspi-134509	168	9	inflammatory	inflammatory	ADJ
ajbspi-134509	168	10	response	response	NOUN
ajbspi-134509	168	11	and	and	CCONJ
ajbspi-134509	168	12	epithelial	epithelial	ADJ
ajbspi-134509	168	13	damage	damage	NOUN
ajbspi-134509	168	14	induced	induce	VERB
ajbspi-134509	168	15	by	by	ADP
ajbspi-134509	168	16	c.	c.	PROPN
ajbspi-134509	168	17	difficile	difficile	NOUN
ajbspi-134509	168	18	toxins	toxin	NOUN
ajbspi-134509	168	19	would	would	AUX
ajbspi-134509	168	20	lead	lead	VERB
ajbspi-134509	168	21	to	to	ADP
ajbspi-134509	168	22	a	a	DET
ajbspi-134509	168	23	substantial	substantial	ADJ
ajbspi-134509	168	24	release	release	NOUN
ajbspi-134509	168	25	of	of	ADP
ajbspi-134509	168	26	atp	atp	PROPN
ajbspi-134509	168	27	[	[	X
ajbspi-134509	168	28	59	59	NUM
ajbspi-134509	168	29	,	,	PUNCT
ajbspi-134509	168	30	60	60	NUM
ajbspi-134509	168	31	,	,	PUNCT
ajbspi-134509	168	32	61	61	NUM
ajbspi-134509	168	33	,	,	PUNCT
ajbspi-134509	168	34	62	62	NUM
ajbspi-134509	168	35	,	,	PUNCT
ajbspi-134509	168	36	63	63	NUM
ajbspi-134509	168	37	,	,	PUNCT
ajbspi-134509	168	38	64	64	NUM
ajbspi-134509	168	39	,	,	PUNCT
ajbspi-134509	168	40	65	65	NUM
ajbspi-134509	168	41	,	,	PUNCT
ajbspi-134509	168	42	66	66	NUM
ajbspi-134509	168	43	]	]	PUNCT
ajbspi-134509	168	44	.	.	PUNCT
ajbspi-134509	169	1	while	while	SCONJ
ajbspi-134509	169	2	initial	initial	ADJ
ajbspi-134509	169	3	atp	atp	NOUN
ajbspi-134509	169	4	signaling	signal	VERB
ajbspi-134509	169	5	might	might	AUX
ajbspi-134509	169	6	contribute	contribute	VERB
ajbspi-134509	169	7	to	to	ADP
ajbspi-134509	169	8	acute	acute	ADJ
ajbspi-134509	169	9	inflammation	inflammation	NOUN
ajbspi-134509	169	10	,	,	PUNCT
ajbspi-134509	169	11	its	its	PRON
ajbspi-134509	169	12	subsequent	subsequent	ADJ
ajbspi-134509	169	13	enzymatic	enzymatic	ADJ
ajbspi-134509	169	14	degradation	degradation	NOUN
ajbspi-134509	169	15	to	to	PART
ajbspi-134509	169	16	adenosine	adenosine	VERB
ajbspi-134509	169	17	by	by	ADP
ajbspi-134509	169	18	host	host	NOUN
ajbspi-134509	169	19	ectoenzymes	ectoenzyme	NOUN
ajbspi-134509	169	20	could	could	AUX
ajbspi-134509	169	21	rapidly	rapidly	ADV
ajbspi-134509	169	22	shift	shift	VERB
ajbspi-134509	169	23	the	the	DET
ajbspi-134509	169	24	local	local	ADJ
ajbspi-134509	169	25	microenvironment	microenvironment	NOUN
ajbspi-134509	169	26	towards	towards	ADP
ajbspi-134509	169	27	immunosuppression	immunosuppression	NOUN
ajbspi-134509	169	28	.	.	PUNCT
ajbspi-134509	170	1	this	this	DET
ajbspi-134509	170	2	shift	shift	NOUN
ajbspi-134509	170	3	,	,	PUNCT
ajbspi-134509	170	4	mediated	mediate	VERB
ajbspi-134509	170	5	primarily	primarily	ADV
ajbspi-134509	170	6	through	through	ADP
ajbspi-134509	170	7	adenosine	adenosine	NOUN
ajbspi-134509	170	8	a2a	a2a	PROPN
ajbspi-134509	170	9	and	and	CCONJ
ajbspi-134509	170	10	a2b	a2b	NOUN
ajbspi-134509	170	11	receptors	receptor	NOUN
ajbspi-134509	170	12	[	[	X
ajbspi-134509	170	13	3	3	NUM
ajbspi-134509	170	14	,	,	PUNCT
ajbspi-134509	170	15	10	10	NUM
ajbspi-134509	170	16	,	,	PUNCT
ajbspi-134509	170	17	12	12	NUM
ajbspi-134509	170	18	]	]	PUNCT
ajbspi-134509	170	19	,	,	PUNCT
ajbspi-134509	170	20	would	would	AUX
ajbspi-134509	170	21	then	then	ADV
ajbspi-134509	170	22	exert	exert	VERB
ajbspi-134509	170	23	broad	broad	ADJ
ajbspi-134509	170	24	inhibitory	inhibitory	ADJ
ajbspi-134509	170	25	effects	effect	NOUN
ajbspi-134509	170	26	on	on	ADP
ajbspi-134509	170	27	key	key	ADJ
ajbspi-134509	170	28	immune	immune	ADJ
ajbspi-134509	170	29	cell	cell	NOUN
ajbspi-134509	170	30	populations	population	NOUN
ajbspi-134509	170	31	.	.	PUNCT
ajbspi-134509	171	1	for	for	ADP
ajbspi-134509	171	2	instance	instance	NOUN
ajbspi-134509	171	3	,	,	PUNCT
ajbspi-134509	171	4	the	the	DET
ajbspi-134509	171	5	suppression	suppression	NOUN
ajbspi-134509	171	6	of	of	ADP
ajbspi-134509	171	7	neutrophil	neutrophil	ADJ
ajbspi-134509	171	8	recruitment	recruitment	NOUN
ajbspi-134509	171	9	and	and	CCONJ
ajbspi-134509	171	10	activation	activation	NOUN
ajbspi-134509	171	11	[	[	X
ajbspi-134509	171	12	18	18	NUM
ajbspi-134509	171	13	,	,	PUNCT
ajbspi-134509	171	14	19	19	NUM
ajbspi-134509	171	15	,	,	PUNCT
ajbspi-134509	171	16	20	20	NUM
ajbspi-134509	171	17	]	]	PUNCT
ajbspi-134509	171	18	would	would	AUX
ajbspi-134509	171	19	compromise	compromise	VERB
ajbspi-134509	171	20	a	a	DET
ajbspi-134509	171	21	crucial	crucial	ADJ
ajbspi-134509	171	22	early	early	ADJ
ajbspi-134509	171	23	innate	innate	ADJ
ajbspi-134509	171	24	immune	immune	ADJ
ajbspi-134509	171	25	defense	defense	NOUN
ajbspi-134509	171	26	mechanism	mechanism	NOUN
ajbspi-134509	171	27	against	against	ADP
ajbspi-134509	171	28	bacterial	bacterial	ADJ
ajbspi-134509	171	29	pathogens	pathogen	NOUN
ajbspi-134509	171	30	.	.	PUNCT
ajbspi-134509	172	1	similarly	similarly	ADV
ajbspi-134509	172	2	,	,	PUNCT
ajbspi-134509	172	3	the	the	DET
ajbspi-134509	172	4	polarization	polarization	NOUN
ajbspi-134509	172	5	of	of	ADP
ajbspi-134509	172	6	macrophages	macrophage	NOUN
ajbspi-134509	172	7	towards	towards	ADP
ajbspi-134509	172	8	an	an	DET
ajbspi-134509	172	9	m2	m2	PROPN
ajbspi-134509	172	10	(	(	PUNCT
ajbspi-134509	172	11	anti	anti	ADJ
ajbspi-134509	172	12	-	-	ADJ
ajbspi-134509	172	13	inflammatory	inflammatory	ADJ
ajbspi-134509	172	14	)	)	PUNCT
ajbspi-134509	172	15	phenotype	phenotype	NOUN
ajbspi-134509	172	16	[	[	X
ajbspi-134509	172	17	23	23	NUM
ajbspi-134509	172	18	,	,	PUNCT
ajbspi-134509	172	19	24	24	NUM
ajbspi-134509	172	20	,	,	PUNCT
ajbspi-134509	172	21	26	26	NUM
ajbspi-134509	172	22	]	]	PUNCT
ajbspi-134509	172	23	could	could	AUX
ajbspi-134509	172	24	hinder	hinder	VERB
ajbspi-134509	172	25	effective	effective	ADJ
ajbspi-134509	172	26	bacterial	bacterial	ADJ
ajbspi-134509	172	27	clearance	clearance	NOUN
ajbspi-134509	172	28	,	,	PUNCT
ajbspi-134509	172	29	as	as	SCONJ
ajbspi-134509	172	30	m1	m1	NOUN
ajbspi-134509	172	31	macrophages	macrophage	NOUN
ajbspi-134509	172	32	are	be	AUX
ajbspi-134509	172	33	generally	generally	ADV
ajbspi-134509	172	34	more	more	ADV
ajbspi-134509	172	35	adept	adept	ADJ
ajbspi-134509	172	36	at	at	ADP
ajbspi-134509	172	37	direct	direct	ADJ
ajbspi-134509	172	38	pathogen	pathogen	NOUN
ajbspi-134509	172	39	killing	killing	NOUN
ajbspi-134509	172	40	.	.	PUNCT
ajbspi-134509	173	1	the	the	DET
ajbspi-134509	173	2	dampening	dampening	NOUN
ajbspi-134509	173	3	of	of	ADP
ajbspi-134509	173	4	dendritic	dendritic	ADJ
ajbspi-134509	173	5	cell	cell	NOUN
ajbspi-134509	173	6	function	function	NOUN
ajbspi-134509	173	7	[	[	X
ajbspi-134509	173	8	29	29	NUM
ajbspi-134509	173	9	,	,	PUNCT
ajbspi-134509	173	10	30	30	NUM
ajbspi-134509	173	11	]	]	PUNCT
ajbspi-134509	173	12	would	would	AUX
ajbspi-134509	173	13	impede	impede	VERB
ajbspi-134509	173	14	efficient	efficient	ADJ
ajbspi-134509	173	15	antigen	antigen	ADJ
ajbspi-134509	173	16	presentation	presentation	NOUN
ajbspi-134509	173	17	and	and	CCONJ
ajbspi-134509	173	18	subsequent	subsequent	ADJ
ajbspi-134509	173	19	activation	activation	NOUN
ajbspi-134509	173	20	of	of	ADP
ajbspi-134509	173	21	adaptive	adaptive	ADJ
ajbspi-134509	173	22	t	t	NOUN
ajbspi-134509	173	23	cell	cell	NOUN
ajbspi-134509	173	24	responses	response	NOUN
ajbspi-134509	173	25	,	,	PUNCT
ajbspi-134509	173	26	which	which	PRON
ajbspi-134509	173	27	are	be	AUX
ajbspi-134509	173	28	essential	essential	ADJ
ajbspi-134509	173	29	for	for	ADP
ajbspi-134509	173	30	longterm	longterm	NOUN
ajbspi-134509	173	31	immunity	immunity	NOUN
ajbspi-134509	173	32	and	and	CCONJ
ajbspi-134509	173	33	preventing	prevent	VERB
ajbspi-134509	173	34	recurrence	recurrence	NOUN
ajbspi-134509	173	35	.	.	PUNCT
ajbspi-134509	174	1	furthermore	furthermore	ADV
ajbspi-134509	174	2	,	,	PUNCT
ajbspi-134509	174	3	the	the	DET
ajbspi-134509	174	4	direct	direct	ADJ
ajbspi-134509	174	5	inhibitory	inhibitory	ADJ
ajbspi-134509	174	6	effects	effect	NOUN
ajbspi-134509	174	7	of	of	ADP
ajbspi-134509	174	8	adenosine	adenosine	NOUN
ajbspi-134509	174	9	on	on	ADP
ajbspi-134509	174	10	effector	effector	NOUN
ajbspi-134509	174	11	t	t	PROPN
ajbspi-134509	174	12	cells	cell	NOUN
ajbspi-134509	174	13	(	(	PUNCT
ajbspi-134509	174	14	both	both	CCONJ
ajbspi-134509	174	15	cd4	cd4	PROPN
ajbspi-134509	174	16	+	+	PROPN
ajbspi-134509	174	17	and	and	CCONJ
ajbspi-134509	174	18	cd8	cd8	PROPN
ajbspi-134509	174	19	+	+	PROPN
ajbspi-134509	174	20	)	)	PUNCT
ajbspi-134509	174	21	[	[	X
ajbspi-134509	174	22	33	33	NUM
ajbspi-134509	174	23	,	,	PUNCT
ajbspi-134509	174	24	34	34	NUM
ajbspi-134509	174	25	,	,	PUNCT
ajbspi-134509	174	26	35	35	NUM
ajbspi-134509	174	27	,	,	PUNCT
ajbspi-134509	174	28	51	51	NUM
ajbspi-134509	174	29	]	]	PUNCT
ajbspi-134509	174	30	and	and	CCONJ
ajbspi-134509	174	31	the	the	DET
ajbspi-134509	174	32	promotion	promotion	NOUN
ajbspi-134509	174	33	of	of	ADP
ajbspi-134509	174	34	regulatory	regulatory	ADJ
ajbspi-134509	174	35	t	t	NOUN
ajbspi-134509	174	36	cells	cell	NOUN
ajbspi-134509	174	37	(	(	PUNCT
ajbspi-134509	174	38	tregs	treg	NOUN
ajbspi-134509	174	39	)	)	PUNCT
ajbspi-134509	174	40	[	[	X
ajbspi-134509	174	41	50	50	NUM
ajbspi-134509	174	42	,	,	PUNCT
ajbspi-134509	174	43	51	51	NUM
ajbspi-134509	174	44	]	]	PUNCT
ajbspi-134509	174	45	would	would	AUX
ajbspi-134509	174	46	collectively	collectively	ADV
ajbspi-134509	174	47	create	create	VERB
ajbspi-134509	174	48	an	an	DET
ajbspi-134509	174	49	immune	immune	ADJ
ajbspi-134509	174	50	-	-	PUNCT
ajbspi-134509	174	51	tolerant	tolerant	ADJ
ajbspi-134509	174	52	environment	environment	NOUN
ajbspi-134509	174	53	within	within	ADP
ajbspi-134509	174	54	the	the	DET
ajbspi-134509	174	55	gut	gut	NOUN
ajbspi-134509	174	56	,	,	PUNCT
ajbspi-134509	174	57	potentially	potentially	ADV
ajbspi-134509	174	58	allowing	allow	VERB
ajbspi-134509	174	59	c.	c.	NOUN
ajbspi-134509	174	60	difficile	difficile	VERB
ajbspi-134509	174	61	to	to	PART
ajbspi-134509	174	62	persist	persist	VERB
ajbspi-134509	174	63	and	and	CCONJ
ajbspi-134509	174	64	re	re	VERB
ajbspi-134509	174	65	-	-	VERB
ajbspi-134509	174	66	establish	establish	VERB
ajbspi-134509	174	67	infection	infection	NOUN
ajbspi-134509	174	68	.	.	PUNCT
ajbspi-134509	175	1	the	the	DET
ajbspi-134509	175	2	upregulation	upregulation	NOUN
ajbspi-134509	175	3	of	of	ADP
ajbspi-134509	175	4	cd39	cd39	PROPN
ajbspi-134509	175	5	/	/	SYM
ajbspi-134509	175	6	cd73	cd73	PROPN
ajbspi-134509	175	7	on	on	ADP
ajbspi-134509	175	8	various	various	ADJ
ajbspi-134509	175	9	immune	immune	ADJ
ajbspi-134509	175	10	cells	cell	NOUN
ajbspi-134509	175	11	,	,	PUNCT
ajbspi-134509	175	12	including	include	VERB
ajbspi-134509	175	13	mdscs	mdsc	NOUN
ajbspi-134509	175	14	[	[	X
ajbspi-134509	175	15	37	37	NUM
ajbspi-134509	175	16	,	,	PUNCT
ajbspi-134509	175	17	38	38	NUM
ajbspi-134509	175	18	,	,	PUNCT
ajbspi-134509	175	19	39	39	NUM
ajbspi-134509	175	20	,	,	PUNCT
ajbspi-134509	175	21	40	40	NUM
ajbspi-134509	175	22	]	]	PUNCT
ajbspi-134509	175	23	and	and	CCONJ
ajbspi-134509	175	24	t	t	NOUN
ajbspi-134509	175	25	cells	cell	NOUN
ajbspi-134509	175	26	[	[	X
ajbspi-134509	175	27	36	36	NUM
ajbspi-134509	175	28	,	,	PUNCT
ajbspi-134509	175	29	37	37	NUM
ajbspi-134509	175	30	,	,	PUNCT
ajbspi-134509	175	31	38	38	NUM
ajbspi-134509	175	32	,	,	PUNCT
ajbspi-134509	175	33	39	39	NUM
ajbspi-134509	175	34	,	,	PUNCT
ajbspi-134509	175	35	40	40	NUM
ajbspi-134509	175	36	]	]	PUNCT
ajbspi-134509	175	37	,	,	PUNCT
ajbspi-134509	175	38	further	far	ADV
ajbspi-134509	175	39	contributes	contribute	VERB
ajbspi-134509	175	40	to	to	ADP
ajbspi-134509	175	41	this	this	DET
ajbspi-134509	175	42	adenosine	adenosine	NOUN
ajbspi-134509	175	43	-	-	PUNCT
ajbspi-134509	175	44	rich	rich	ADJ
ajbspi-134509	175	45	,	,	PUNCT
ajbspi-134509	175	46	immunosuppressive	immunosuppressive	ADJ
ajbspi-134509	175	47	milieu	milieu	NOUN
ajbspi-134509	175	48	.	.	PUNCT
ajbspi-134509	176	1	the	the	DET
ajbspi-134509	176	2	hypothesized	hypothesized	ADJ
ajbspi-134509	176	3	manipulation	manipulation	NOUN
ajbspi-134509	176	4	by	by	ADP
ajbspi-134509	176	5	c.	c.	PROPN
ajbspi-134509	176	6	difficile	difficile	PROPN
ajbspi-134509	176	7	is	be	AUX
ajbspi-134509	176	8	likely	likely	ADJ
ajbspi-134509	176	9	american	american	ADJ
ajbspi-134509	176	10	journal	journal	NOUN
ajbspi-134509	176	11	of	of	ADP
ajbspi-134509	176	12	applied	apply	VERB
ajbspi-134509	176	13	science	science	NOUN
ajbspi-134509	176	14	and	and	CCONJ
ajbspi-134509	176	15	technology	technology	NOUN
ajbspi-134509	176	16	7	7	NUM
ajbspi-134509	176	17	https://theusajournals.com/index.php/ajast	https://theusajournals.com/index.php/ajast	VERB
ajbspi-134509	176	18	american	american	PROPN
ajbspi-134509	176	19	journal	journal	PROPN
ajbspi-134509	176	20	of	of	ADP
ajbspi-134509	176	21	applied	apply	VERB
ajbspi-134509	176	22	science	science	NOUN
ajbspi-134509	176	23	and	and	CCONJ
ajbspi-134509	176	24	technology	technology	NOUN
ajbspi-134509	176	25	(	(	PUNCT
ajbspi-134509	176	26	issn	issn	PROPN
ajbspi-134509	176	27	:	:	PUNCT
ajbspi-134509	176	28	2771	2771	NUM
ajbspi-134509	176	29	-	-	SYM
ajbspi-134509	176	30	2745	2745	NUM
ajbspi-134509	176	31	)	)	PUNCT
ajbspi-134509	176	32	multifaceted	multifaceted	ADJ
ajbspi-134509	176	33	.	.	PUNCT
ajbspi-134509	177	1	the	the	DET
ajbspi-134509	177	2	primary	primary	ADJ
ajbspi-134509	177	3	mechanism	mechanism	NOUN
ajbspi-134509	177	4	appears	appear	VERB
ajbspi-134509	177	5	to	to	PART
ajbspi-134509	177	6	be	be	AUX
ajbspi-134509	177	7	an	an	DET
ajbspi-134509	177	8	indirect	indirect	ADJ
ajbspi-134509	177	9	exploitation	exploitation	NOUN
ajbspi-134509	177	10	of	of	ADP
ajbspi-134509	177	11	the	the	DET
ajbspi-134509	177	12	host	host	NOUN
ajbspi-134509	177	13	's	's	PART
ajbspi-134509	177	14	own	own	ADJ
ajbspi-134509	177	15	damageresponse	damageresponse	NOUN
ajbspi-134509	177	16	pathways	pathway	NOUN
ajbspi-134509	177	17	.	.	PUNCT
ajbspi-134509	178	1	by	by	ADP
ajbspi-134509	178	2	inducing	induce	VERB
ajbspi-134509	178	3	widespread	widespread	ADJ
ajbspi-134509	178	4	cellular	cellular	ADJ
ajbspi-134509	178	5	injury	injury	NOUN
ajbspi-134509	178	6	and	and	CCONJ
ajbspi-134509	178	7	inflammation	inflammation	NOUN
ajbspi-134509	178	8	,	,	PUNCT
ajbspi-134509	178	9	c.	c.	NOUN
ajbspi-134509	178	10	difficile	difficile	NOUN
ajbspi-134509	178	11	toxins	toxin	NOUN
ajbspi-134509	178	12	effectively	effectively	ADV
ajbspi-134509	178	13	trigger	trigger	VERB
ajbspi-134509	178	14	the	the	DET
ajbspi-134509	178	15	release	release	NOUN
ajbspi-134509	178	16	of	of	ADP
ajbspi-134509	178	17	pro	pro	ADJ
ajbspi-134509	178	18	-	-	ADJ
ajbspi-134509	178	19	inflammatory	inflammatory	ADJ
ajbspi-134509	178	20	atp	atp	NOUN
ajbspi-134509	178	21	,	,	PUNCT
ajbspi-134509	178	22	which	which	PRON
ajbspi-134509	178	23	is	be	AUX
ajbspi-134509	178	24	then	then	ADV
ajbspi-134509	178	25	converted	convert	VERB
ajbspi-134509	178	26	by	by	ADP
ajbspi-134509	178	27	host	host	NOUN
ajbspi-134509	178	28	ectoenzymes	ectoenzyme	NOUN
ajbspi-134509	178	29	into	into	ADP
ajbspi-134509	178	30	immunosuppressive	immunosuppressive	ADJ
ajbspi-134509	178	31	adenosine	adenosine	NOUN
ajbspi-134509	178	32	.	.	PUNCT
ajbspi-134509	179	1	this	this	DET
ajbspi-134509	179	2	"	"	PUNCT
ajbspi-134509	179	3	self	self	NOUN
ajbspi-134509	179	4	-	-	PUNCT
ajbspi-134509	179	5	sabotage	sabotage	NOUN
ajbspi-134509	179	6	"	"	PUNCT
ajbspi-134509	179	7	of	of	ADP
ajbspi-134509	179	8	the	the	DET
ajbspi-134509	179	9	host	host	NOUN
ajbspi-134509	179	10	immune	immune	ADJ
ajbspi-134509	179	11	response	response	NOUN
ajbspi-134509	179	12	creates	create	VERB
ajbspi-134509	179	13	a	a	DET
ajbspi-134509	179	14	favorable	favorable	ADJ
ajbspi-134509	179	15	niche	niche	NOUN
ajbspi-134509	179	16	for	for	ADP
ajbspi-134509	179	17	the	the	DET
ajbspi-134509	179	18	pathogen	pathogen	NOUN
ajbspi-134509	179	19	.	.	PUNCT
ajbspi-134509	180	1	while	while	SCONJ
ajbspi-134509	180	2	direct	direct	ADJ
ajbspi-134509	180	3	bacterial	bacterial	ADJ
ajbspi-134509	180	4	production	production	NOUN
ajbspi-134509	180	5	of	of	ADP
ajbspi-134509	180	6	adenosine	adenosine	NOUN
ajbspi-134509	180	7	-	-	PUNCT
ajbspi-134509	180	8	modulating	modulate	VERB
ajbspi-134509	180	9	enzymes	enzyme	NOUN
ajbspi-134509	180	10	by	by	ADP
ajbspi-134509	180	11	c.	c.	PROPN
ajbspi-134509	180	12	difficile	difficile	PROPN
ajbspi-134509	180	13	is	be	AUX
ajbspi-134509	180	14	not	not	PART
ajbspi-134509	180	15	explicitly	explicitly	ADV
ajbspi-134509	180	16	detailed	detail	VERB
ajbspi-134509	180	17	in	in	ADP
ajbspi-134509	180	18	the	the	DET
ajbspi-134509	180	19	provided	provide	VERB
ajbspi-134509	180	20	references	reference	NOUN
ajbspi-134509	180	21	,	,	PUNCT
ajbspi-134509	180	22	it	it	PRON
ajbspi-134509	180	23	remains	remain	VERB
ajbspi-134509	180	24	a	a	DET
ajbspi-134509	180	25	fascinating	fascinating	ADJ
ajbspi-134509	180	26	area	area	NOUN
ajbspi-134509	180	27	for	for	ADP
ajbspi-134509	180	28	future	future	ADJ
ajbspi-134509	180	29	investigation	investigation	NOUN
ajbspi-134509	180	30	,	,	PUNCT
ajbspi-134509	180	31	given	give	VERB
ajbspi-134509	180	32	that	that	SCONJ
ajbspi-134509	180	33	other	other	ADJ
ajbspi-134509	180	34	pathogens	pathogen	NOUN
ajbspi-134509	180	35	are	be	AUX
ajbspi-134509	180	36	known	know	VERB
ajbspi-134509	180	37	to	to	PART
ajbspi-134509	180	38	directly	directly	ADV
ajbspi-134509	180	39	interfere	interfere	VERB
ajbspi-134509	180	40	with	with	ADP
ajbspi-134509	180	41	host	host	NOUN
ajbspi-134509	180	42	purinergic	purinergic	NOUN
ajbspi-134509	180	43	signaling	signal	VERB
ajbspi-134509	180	44	.	.	PUNCT
ajbspi-134509	181	1	these	these	DET
ajbspi-134509	181	2	insights	insight	NOUN
ajbspi-134509	181	3	open	open	VERB
ajbspi-134509	181	4	promising	promising	ADJ
ajbspi-134509	181	5	avenues	avenue	NOUN
ajbspi-134509	181	6	for	for	ADP
ajbspi-134509	181	7	novel	novel	ADJ
ajbspi-134509	181	8	therapeutic	therapeutic	ADJ
ajbspi-134509	181	9	strategies	strategy	NOUN
ajbspi-134509	181	10	against	against	ADP
ajbspi-134509	181	11	cdi	cdi	PROPN
ajbspi-134509	181	12	.	.	PUNCT
ajbspi-134509	181	13	instead	instead	ADV
ajbspi-134509	181	14	of	of	ADP
ajbspi-134509	181	15	solely	solely	ADV
ajbspi-134509	181	16	targeting	target	VERB
ajbspi-134509	181	17	the	the	DET
ajbspi-134509	181	18	bacterium	bacterium	NOUN
ajbspi-134509	181	19	or	or	CCONJ
ajbspi-134509	181	20	its	its	PRON
ajbspi-134509	181	21	toxins	toxin	NOUN
ajbspi-134509	181	22	,	,	PUNCT
ajbspi-134509	181	23	modulating	modulate	VERB
ajbspi-134509	181	24	the	the	DET
ajbspi-134509	181	25	host	host	NOUN
ajbspi-134509	181	26	adenosine	adenosine	NOUN
ajbspi-134509	181	27	pathway	pathway	NOUN
ajbspi-134509	181	28	could	could	AUX
ajbspi-134509	181	29	represent	represent	VERB
ajbspi-134509	181	30	a	a	DET
ajbspi-134509	181	31	powerful	powerful	ADJ
ajbspi-134509	181	32	adjunctive	adjunctive	ADJ
ajbspi-134509	181	33	therapy	therapy	NOUN
ajbspi-134509	181	34	.	.	PUNCT
ajbspi-134509	182	1	for	for	ADP
ajbspi-134509	182	2	example	example	NOUN
ajbspi-134509	182	3	,	,	PUNCT
ajbspi-134509	182	4	pharmacological	pharmacological	ADJ
ajbspi-134509	182	5	blockade	blockade	NOUN
ajbspi-134509	182	6	of	of	ADP
ajbspi-134509	182	7	adenosine	adenosine	NOUN
ajbspi-134509	182	8	a2a	a2a	PROPN
ajbspi-134509	182	9	or	or	CCONJ
ajbspi-134509	182	10	a2b	a2b	PROPN
ajbspi-134509	182	11	receptors	receptor	NOUN
ajbspi-134509	182	12	,	,	PUNCT
ajbspi-134509	182	13	particularly	particularly	ADV
ajbspi-134509	182	14	in	in	ADP
ajbspi-134509	182	15	the	the	DET
ajbspi-134509	182	16	gut	gut	NOUN
ajbspi-134509	182	17	,	,	PUNCT
ajbspi-134509	182	18	could	could	AUX
ajbspi-134509	182	19	potentially	potentially	ADV
ajbspi-134509	182	20	reverse	reverse	VERB
ajbspi-134509	182	21	the	the	DET
ajbspi-134509	182	22	adenosine	adenosine	NOUN
ajbspi-134509	182	23	-	-	PUNCT
ajbspi-134509	182	24	mediated	mediate	VERB
ajbspi-134509	182	25	immunosuppression	immunosuppression	NOUN
ajbspi-134509	182	26	,	,	PUNCT
ajbspi-134509	182	27	thereby	thereby	ADV
ajbspi-134509	182	28	enhancing	enhance	VERB
ajbspi-134509	182	29	the	the	DET
ajbspi-134509	182	30	host	host	NOUN
ajbspi-134509	182	31	's	's	PART
ajbspi-134509	182	32	innate	innate	ADJ
ajbspi-134509	182	33	and	and	CCONJ
ajbspi-134509	182	34	adaptive	adaptive	ADJ
ajbspi-134509	182	35	immune	immune	ADJ
ajbspi-134509	182	36	responses	response	NOUN
ajbspi-134509	182	37	to	to	PART
ajbspi-134509	182	38	clear	clear	VERB
ajbspi-134509	182	39	the	the	DET
ajbspi-134509	182	40	infection	infection	NOUN
ajbspi-134509	182	41	[	[	X
ajbspi-134509	182	42	17	17	NUM
ajbspi-134509	182	43	,	,	PUNCT
ajbspi-134509	182	44	21	21	NUM
ajbspi-134509	182	45	,	,	PUNCT
ajbspi-134509	182	46	25	25	NUM
ajbspi-134509	182	47	,	,	PUNCT
ajbspi-134509	182	48	31	31	NUM
ajbspi-134509	182	49	,	,	PUNCT
ajbspi-134509	182	50	32	32	NUM
ajbspi-134509	182	51	,	,	PUNCT
ajbspi-134509	182	52	35	35	NUM
ajbspi-134509	182	53	,	,	PUNCT
ajbspi-134509	182	54	44	44	NUM
ajbspi-134509	182	55	,	,	PUNCT
ajbspi-134509	182	56	45	45	NUM
ajbspi-134509	182	57	,	,	PUNCT
ajbspi-134509	182	58	46	46	NUM
ajbspi-134509	182	59	]	]	PUNCT
ajbspi-134509	182	60	.	.	PUNCT
ajbspi-134509	183	1	inhibitors	inhibitor	NOUN
ajbspi-134509	183	2	of	of	ADP
ajbspi-134509	183	3	cd39	cd39	PROPN
ajbspi-134509	183	4	or	or	CCONJ
ajbspi-134509	183	5	cd73	cd73	PROPN
ajbspi-134509	183	6	could	could	AUX
ajbspi-134509	183	7	also	also	ADV
ajbspi-134509	183	8	be	be	AUX
ajbspi-134509	183	9	explored	explore	VERB
ajbspi-134509	183	10	to	to	PART
ajbspi-134509	183	11	prevent	prevent	VERB
ajbspi-134509	183	12	the	the	DET
ajbspi-134509	183	13	conversion	conversion	NOUN
ajbspi-134509	183	14	of	of	ADP
ajbspi-134509	183	15	proinflammatory	proinflammatory	ADJ
ajbspi-134509	183	16	atp	atp	NOUN
ajbspi-134509	183	17	to	to	ADP
ajbspi-134509	183	18	immunosuppressive	immunosuppressive	ADJ
ajbspi-134509	183	19	adenosine	adenosine	NOUN
ajbspi-134509	183	20	,	,	PUNCT
ajbspi-134509	183	21	thereby	thereby	ADV
ajbspi-134509	183	22	maintaining	maintain	VERB
ajbspi-134509	183	23	a	a	DET
ajbspi-134509	183	24	more	more	ADV
ajbspi-134509	183	25	robust	robust	ADJ
ajbspi-134509	183	26	anti	anti	ADJ
ajbspi-134509	183	27	-	-	ADJ
ajbspi-134509	183	28	bacterial	bacterial	ADJ
ajbspi-134509	183	29	immune	immune	ADJ
ajbspi-134509	183	30	response	response	NOUN
ajbspi-134509	183	31	[	[	X
ajbspi-134509	183	32	21	21	NUM
ajbspi-134509	183	33	,	,	PUNCT
ajbspi-134509	183	34	31	31	NUM
ajbspi-134509	183	35	,	,	PUNCT
ajbspi-134509	183	36	32	32	NUM
ajbspi-134509	183	37	,	,	PUNCT
ajbspi-134509	183	38	35	35	NUM
ajbspi-134509	183	39	,	,	PUNCT
ajbspi-134509	183	40	44	44	NUM
ajbspi-134509	183	41	,	,	PUNCT
ajbspi-134509	183	42	45	45	NUM
ajbspi-134509	183	43	,	,	PUNCT
ajbspi-134509	183	44	46	46	NUM
ajbspi-134509	183	45	]	]	PUNCT
ajbspi-134509	183	46	.	.	PUNCT
ajbspi-134509	184	1	however	however	ADV
ajbspi-134509	184	2	,	,	PUNCT
ajbspi-134509	184	3	careful	careful	ADJ
ajbspi-134509	184	4	consideration	consideration	NOUN
ajbspi-134509	184	5	of	of	ADP
ajbspi-134509	184	6	potential	potential	ADJ
ajbspi-134509	184	7	off	off	ADP
ajbspi-134509	184	8	-	-	PUNCT
ajbspi-134509	184	9	target	target	NOUN
ajbspi-134509	184	10	effects	effect	NOUN
ajbspi-134509	184	11	and	and	CCONJ
ajbspi-134509	184	12	the	the	DET
ajbspi-134509	184	13	systemic	systemic	ADJ
ajbspi-134509	184	14	roles	role	NOUN
ajbspi-134509	184	15	of	of	ADP
ajbspi-134509	184	16	adenosine	adenosine	NOUN
ajbspi-134509	184	17	in	in	ADP
ajbspi-134509	184	18	other	other	ADJ
ajbspi-134509	184	19	physiological	physiological	ADJ
ajbspi-134509	184	20	processes	process	NOUN
ajbspi-134509	184	21	(	(	PUNCT
ajbspi-134509	184	22	e.g.	e.g.	ADV
ajbspi-134509	184	23	,	,	PUNCT
ajbspi-134509	184	24	cardiovascular	cardiovascular	ADJ
ajbspi-134509	184	25	function	function	NOUN
ajbspi-134509	184	26	[	[	X
ajbspi-134509	184	27	4	4	NUM
ajbspi-134509	184	28	]	]	PUNCT
ajbspi-134509	184	29	,	,	PUNCT
ajbspi-134509	184	30	neurological	neurological	ADJ
ajbspi-134509	184	31	modulation	modulation	NOUN
ajbspi-134509	184	32	[	[	X
ajbspi-134509	184	33	22	22	NUM
ajbspi-134509	184	34	]	]	PUNCT
ajbspi-134509	184	35	)	)	PUNCT
ajbspi-134509	184	36	would	would	AUX
ajbspi-134509	184	37	be	be	AUX
ajbspi-134509	184	38	critical	critical	ADJ
ajbspi-134509	184	39	for	for	ADP
ajbspi-134509	184	40	such	such	ADJ
ajbspi-134509	184	41	therapeutic	therapeutic	ADJ
ajbspi-134509	184	42	approaches	approach	NOUN
ajbspi-134509	184	43	.	.	PUNCT
ajbspi-134509	185	1	despite	despite	SCONJ
ajbspi-134509	185	2	the	the	DET
ajbspi-134509	185	3	compelling	compelling	ADJ
ajbspi-134509	185	4	theoretical	theoretical	ADJ
ajbspi-134509	185	5	framework	framework	NOUN
ajbspi-134509	185	6	,	,	PUNCT
ajbspi-134509	185	7	significant	significant	ADJ
ajbspi-134509	185	8	gaps	gap	NOUN
ajbspi-134509	185	9	in	in	ADP
ajbspi-134509	185	10	current	current	ADJ
ajbspi-134509	185	11	knowledge	knowledge	NOUN
ajbspi-134509	185	12	remain	remain	VERB
ajbspi-134509	185	13	.	.	PUNCT
ajbspi-134509	186	1	direct	direct	ADJ
ajbspi-134509	186	2	experimental	experimental	ADJ
ajbspi-134509	186	3	evidence	evidence	NOUN
ajbspi-134509	186	4	demonstrating	demonstrate	VERB
ajbspi-134509	186	5	c.	c.	PROPN
ajbspi-134509	186	6	difficile	difficile	PROPN
ajbspi-134509	186	7	's	's	PART
ajbspi-134509	186	8	specific	specific	ADJ
ajbspi-134509	186	9	mechanisms	mechanism	NOUN
ajbspi-134509	186	10	for	for	ADP
ajbspi-134509	186	11	manipulating	manipulate	VERB
ajbspi-134509	186	12	the	the	DET
ajbspi-134509	186	13	adenosine	adenosine	NOUN
ajbspi-134509	186	14	system	system	NOUN
ajbspi-134509	186	15	is	be	AUX
ajbspi-134509	186	16	largely	largely	ADV
ajbspi-134509	186	17	absent	absent	ADJ
ajbspi-134509	186	18	in	in	ADP
ajbspi-134509	186	19	the	the	DET
ajbspi-134509	186	20	provided	provide	VERB
ajbspi-134509	186	21	literature	literature	NOUN
ajbspi-134509	186	22	.	.	PUNCT
ajbspi-134509	187	1	future	future	ADJ
ajbspi-134509	187	2	research	research	NOUN
ajbspi-134509	187	3	should	should	AUX
ajbspi-134509	187	4	focus	focus	VERB
ajbspi-134509	187	5	on	on	ADP
ajbspi-134509	187	6	:	:	PUNCT
ajbspi-134509	187	7	•	•	NUM
ajbspi-134509	187	8	measuring	measure	VERB
ajbspi-134509	187	9	adenosine	adenosine	NOUN
ajbspi-134509	187	10	levels	level	NOUN
ajbspi-134509	187	11	in	in	ADP
ajbspi-134509	187	12	cdi	cdi	PROPN
ajbspi-134509	187	13	:	:	PUNCT
ajbspi-134509	187	14	quantifying	quantify	VERB
ajbspi-134509	187	15	extracellular	extracellular	ADJ
ajbspi-134509	187	16	atp	atp	NOUN
ajbspi-134509	187	17	and	and	CCONJ
ajbspi-134509	187	18	adenosine	adenosine	ADJ
ajbspi-134509	187	19	concentrations	concentration	NOUN
ajbspi-134509	187	20	in	in	ADP
ajbspi-134509	187	21	the	the	DET
ajbspi-134509	187	22	gut	gut	NOUN
ajbspi-134509	187	23	lumen	luman	NOUN
ajbspi-134509	187	24	and	and	CCONJ
ajbspi-134509	187	25	intestinal	intestinal	ADJ
ajbspi-134509	187	26	tissue	tissue	NOUN
ajbspi-134509	187	27	of	of	ADP
ajbspi-134509	187	28	cdi	cdi	PROPN
ajbspi-134509	187	29	patients	patient	NOUN
ajbspi-134509	187	30	and	and	CCONJ
ajbspi-134509	187	31	animal	animal	NOUN
ajbspi-134509	187	32	models	model	NOUN
ajbspi-134509	187	33	to	to	PART
ajbspi-134509	187	34	confirm	confirm	VERB
ajbspi-134509	187	35	the	the	DET
ajbspi-134509	187	36	hypothesized	hypothesized	ADJ
ajbspi-134509	187	37	shifts	shift	NOUN
ajbspi-134509	187	38	during	during	ADP
ajbspi-134509	187	39	infection	infection	NOUN
ajbspi-134509	187	40	.	.	PUNCT
ajbspi-134509	188	1	•	•	PUNCT
ajbspi-134509	188	2	investigating	investigate	VERB
ajbspi-134509	188	3	bacterial	bacterial	ADJ
ajbspi-134509	188	4	enzymes	enzyme	NOUN
ajbspi-134509	188	5	:	:	PUNCT
ajbspi-134509	188	6	screening	screen	VERB
ajbspi-134509	188	7	c.	c.	NOUN
ajbspi-134509	188	8	difficile	difficile	VERB
ajbspi-134509	188	9	strains	strain	VERB
ajbspi-134509	188	10	for	for	ADP
ajbspi-134509	188	11	the	the	DET
ajbspi-134509	188	12	presence	presence	NOUN
ajbspi-134509	188	13	and	and	CCONJ
ajbspi-134509	188	14	activity	activity	NOUN
ajbspi-134509	188	15	of	of	ADP
ajbspi-134509	188	16	ectonucleotidases	ectonucleotidase	NOUN
ajbspi-134509	188	17	or	or	CCONJ
ajbspi-134509	188	18	other	other	ADJ
ajbspi-134509	188	19	enzymes	enzyme	NOUN
ajbspi-134509	188	20	that	that	PRON
ajbspi-134509	188	21	could	could	AUX
ajbspi-134509	188	22	directly	directly	ADV
ajbspi-134509	188	23	influence	influence	VERB
ajbspi-134509	188	24	extracellular	extracellular	ADJ
ajbspi-134509	188	25	purine	purine	NOUN
ajbspi-134509	188	26	metabolism	metabolism	NOUN
ajbspi-134509	188	27	.	.	PUNCT
ajbspi-134509	189	1	•	•	NUM
ajbspi-134509	189	2	genetic	genetic	ADJ
ajbspi-134509	189	3	manipulation	manipulation	NOUN
ajbspi-134509	189	4	studies	study	NOUN
ajbspi-134509	189	5	:	:	PUNCT
ajbspi-134509	189	6	utilizing	utilize	VERB
ajbspi-134509	189	7	c.	c.	NOUN
ajbspi-134509	189	8	difficile	difficile	ADJ
ajbspi-134509	189	9	mutants	mutant	NOUN
ajbspi-134509	189	10	lacking	lack	VERB
ajbspi-134509	189	11	specific	specific	ADJ
ajbspi-134509	189	12	virulence	virulence	NOUN
ajbspi-134509	189	13	factors	factor	NOUN
ajbspi-134509	189	14	or	or	CCONJ
ajbspi-134509	189	15	host	host	NOUN
ajbspi-134509	189	16	knockout	knockout	NOUN
ajbspi-134509	189	17	/	/	SYM
ajbspi-134509	189	18	pharmacological	pharmacological	NOUN
ajbspi-134509	189	19	models	model	NOUN
ajbspi-134509	189	20	targeting	target	VERB
ajbspi-134509	189	21	cd39	cd39	PROPN
ajbspi-134509	189	22	,	,	PUNCT
ajbspi-134509	189	23	cd73	cd73	PROPN
ajbspi-134509	189	24	,	,	PUNCT
ajbspi-134509	189	25	or	or	CCONJ
ajbspi-134509	189	26	adenosine	adenosine	NOUN
ajbspi-134509	189	27	receptors	receptor	NOUN
ajbspi-134509	189	28	to	to	PART
ajbspi-134509	189	29	delineate	delineate	VERB
ajbspi-134509	189	30	their	their	PRON
ajbspi-134509	189	31	precise	precise	ADJ
ajbspi-134509	189	32	roles	role	NOUN
ajbspi-134509	189	33	in	in	ADP
ajbspi-134509	189	34	cdi	cdi	PROPN
ajbspi-134509	189	35	pathogenesis	pathogenesis	NOUN
ajbspi-134509	189	36	and	and	CCONJ
ajbspi-134509	189	37	host	host	NOUN
ajbspi-134509	189	38	defense	defense	NOUN
ajbspi-134509	189	39	.	.	PUNCT
ajbspi-134509	190	1	•	•	NUM
ajbspi-134509	190	2	immune	immune	ADJ
ajbspi-134509	190	3	cell	cell	NOUN
ajbspi-134509	190	4	profiling	profiling	NOUN
ajbspi-134509	190	5	:	:	PUNCT
ajbspi-134509	190	6	detailed	detailed	ADJ
ajbspi-134509	190	7	analysis	analysis	NOUN
ajbspi-134509	190	8	of	of	ADP
ajbspi-134509	190	9	adenosine	adenosine	ADJ
ajbspi-134509	190	10	receptor	receptor	NOUN
ajbspi-134509	190	11	expression	expression	NOUN
ajbspi-134509	190	12	and	and	CCONJ
ajbspi-134509	190	13	function	function	NOUN
ajbspi-134509	190	14	on	on	ADP
ajbspi-134509	190	15	gutresident	gutresident	ADJ
ajbspi-134509	190	16	immune	immune	ADJ
ajbspi-134509	190	17	cells	cell	NOUN
ajbspi-134509	190	18	during	during	ADP
ajbspi-134509	190	19	cdi	cdi	PROPN
ajbspi-134509	190	20	.	.	PROPN
ajbspi-134509	190	21	•	•	NUM
ajbspi-134509	190	22	therapeutic	therapeutic	ADJ
ajbspi-134509	190	23	validation	validation	NOUN
ajbspi-134509	190	24	:	:	PUNCT
ajbspi-134509	190	25	preclinical	preclinical	ADJ
ajbspi-134509	190	26	and	and	CCONJ
ajbspi-134509	190	27	clinical	clinical	ADJ
ajbspi-134509	190	28	studies	study	NOUN
ajbspi-134509	190	29	to	to	PART
ajbspi-134509	190	30	evaluate	evaluate	VERB
ajbspi-134509	190	31	the	the	DET
ajbspi-134509	190	32	efficacy	efficacy	NOUN
ajbspi-134509	190	33	and	and	CCONJ
ajbspi-134509	190	34	safety	safety	NOUN
ajbspi-134509	190	35	of	of	ADP
ajbspi-134509	190	36	adenosine	adenosine	ADJ
ajbspi-134509	190	37	pathway	pathway	NOUN
ajbspi-134509	190	38	modulators	modulator	NOUN
ajbspi-134509	190	39	as	as	ADP
ajbspi-134509	190	40	adjunctive	adjunctive	ADJ
ajbspi-134509	190	41	therapies	therapy	NOUN
ajbspi-134509	190	42	for	for	ADP
ajbspi-134509	190	43	cdi	cdi	PROPN
ajbspi-134509	190	44	,	,	PUNCT
ajbspi-134509	190	45	potentially	potentially	ADV
ajbspi-134509	190	46	in	in	ADP
ajbspi-134509	190	47	combination	combination	NOUN
ajbspi-134509	190	48	with	with	ADP
ajbspi-134509	190	49	standard	standard	ADJ
ajbspi-134509	190	50	antibiotic	antibiotic	ADJ
ajbspi-134509	190	51	treatments	treatment	NOUN
ajbspi-134509	190	52	.	.	PUNCT
ajbspi-134509	191	1	the	the	DET
ajbspi-134509	191	2	implications	implication	NOUN
ajbspi-134509	191	3	of	of	ADP
ajbspi-134509	191	4	understanding	understand	VERB
ajbspi-134509	191	5	this	this	DET
ajbspi-134509	191	6	microbial	microbial	ADJ
ajbspi-134509	191	7	exploitation	exploitation	NOUN
ajbspi-134509	191	8	extend	extend	VERB
ajbspi-134509	191	9	beyond	beyond	ADP
ajbspi-134509	191	10	c.	c.	NOUN
ajbspi-134509	191	11	difficile	difficile	PROPN
ajbspi-134509	191	12	.	.	PUNCT
ajbspi-134509	192	1	many	many	ADJ
ajbspi-134509	192	2	other	other	ADJ
ajbspi-134509	192	3	gut	gut	NOUN
ajbspi-134509	192	4	pathogens	pathogen	NOUN
ajbspi-134509	192	5	induce	induce	VERB
ajbspi-134509	192	6	inflammation	inflammation	NOUN
ajbspi-134509	192	7	and	and	CCONJ
ajbspi-134509	192	8	tissue	tissue	NOUN
ajbspi-134509	192	9	damage	damage	NOUN
ajbspi-134509	192	10	,	,	PUNCT
ajbspi-134509	192	11	and	and	CCONJ
ajbspi-134509	192	12	it	it	PRON
ajbspi-134509	192	13	is	be	AUX
ajbspi-134509	192	14	plausible	plausible	ADJ
ajbspi-134509	192	15	that	that	SCONJ
ajbspi-134509	192	16	they	they	PRON
ajbspi-134509	192	17	also	also	ADV
ajbspi-134509	192	18	benefit	benefit	VERB
ajbspi-134509	192	19	from	from	ADP
ajbspi-134509	192	20	or	or	CCONJ
ajbspi-134509	192	21	actively	actively	ADV
ajbspi-134509	192	22	manipulate	manipulate	VERB
ajbspi-134509	192	23	the	the	DET
ajbspi-134509	192	24	host	host	NOUN
ajbspi-134509	192	25	adenosine	adenosine	NOUN
ajbspi-134509	192	26	system	system	NOUN
ajbspi-134509	192	27	to	to	PART
ajbspi-134509	192	28	establish	establish	VERB
ajbspi-134509	192	29	chronic	chronic	ADJ
ajbspi-134509	192	30	infections	infection	NOUN
ajbspi-134509	192	31	or	or	CCONJ
ajbspi-134509	192	32	evade	evade	VERB
ajbspi-134509	192	33	immune	immune	ADJ
ajbspi-134509	192	34	clearance	clearance	NOUN
ajbspi-134509	192	35	.	.	PUNCT
ajbspi-134509	193	1	unraveling	unravel	VERB
ajbspi-134509	193	2	these	these	DET
ajbspi-134509	193	3	complex	complex	ADJ
ajbspi-134509	193	4	host	host	NOUN
ajbspi-134509	193	5	-	-	PUNCT
ajbspi-134509	193	6	pathogen	pathogen	NOUN
ajbspi-134509	193	7	interactions	interaction	NOUN
ajbspi-134509	193	8	at	at	ADP
ajbspi-134509	193	9	the	the	DET
ajbspi-134509	193	10	purinergic	purinergic	NOUN
ajbspi-134509	193	11	signaling	signal	VERB
ajbspi-134509	193	12	level	level	NOUN
ajbspi-134509	193	13	could	could	AUX
ajbspi-134509	193	14	pave	pave	VERB
ajbspi-134509	193	15	the	the	DET
ajbspi-134509	193	16	way	way	NOUN
ajbspi-134509	193	17	for	for	ADP
ajbspi-134509	193	18	broadly	broadly	ADV
ajbspi-134509	193	19	applicable	applicable	ADJ
ajbspi-134509	193	20	therapeutic	therapeutic	ADJ
ajbspi-134509	193	21	strategies	strategy	NOUN
ajbspi-134509	193	22	against	against	ADP
ajbspi-134509	193	23	a	a	DET
ajbspi-134509	193	24	range	range	NOUN
ajbspi-134509	193	25	of	of	ADP
ajbspi-134509	193	26	infectious	infectious	ADJ
ajbspi-134509	193	27	diseases	disease	NOUN
ajbspi-134509	193	28	.	.	PUNCT
ajbspi-134509	194	1	the	the	DET
ajbspi-134509	194	2	purinergic	purinergic	NOUN
ajbspi-134509	194	3	signaling	signal	VERB
ajbspi-134509	194	4	system	system	NOUN
ajbspi-134509	194	5	,	,	PUNCT
ajbspi-134509	194	6	with	with	ADP
ajbspi-134509	194	7	its	its	PRON
ajbspi-134509	194	8	intricate	intricate	ADJ
ajbspi-134509	194	9	balance	balance	NOUN
ajbspi-134509	194	10	between	between	ADP
ajbspi-134509	194	11	proinflammatory	proinflammatory	ADJ
ajbspi-134509	194	12	atp	atp	NOUN
ajbspi-134509	194	13	and	and	CCONJ
ajbspi-134509	194	14	anti	anti	ADJ
ajbspi-134509	194	15	-	-	ADJ
ajbspi-134509	194	16	inflammatory	inflammatory	ADJ
ajbspi-134509	194	17	adenosine	adenosine	NOUN
ajbspi-134509	194	18	,	,	PUNCT
ajbspi-134509	194	19	represents	represent	VERB
ajbspi-134509	194	20	a	a	DET
ajbspi-134509	194	21	finely	finely	ADV
ajbspi-134509	194	22	tuned	tune	VERB
ajbspi-134509	194	23	rheostat	rheostat	NOUN
ajbspi-134509	194	24	of	of	ADP
ajbspi-134509	194	25	the	the	DET
ajbspi-134509	194	26	immune	immune	ADJ
ajbspi-134509	194	27	response	response	NOUN
ajbspi-134509	194	28	,	,	PUNCT
ajbspi-134509	194	29	one	one	NUM
ajbspi-134509	194	30	that	that	PRON
ajbspi-134509	194	31	pathogens	pathogen	NOUN
ajbspi-134509	194	32	like	like	ADP
ajbspi-134509	194	33	c.	c.	PROPN
ajbspi-134509	194	34	difficile	difficile	PROPN
ajbspi-134509	194	35	appear	appear	VERB
ajbspi-134509	194	36	to	to	PART
ajbspi-134509	194	37	have	have	AUX
ajbspi-134509	194	38	learned	learn	VERB
ajbspi-134509	194	39	to	to	PART
ajbspi-134509	194	40	exploit	exploit	VERB
ajbspi-134509	194	41	for	for	ADP
ajbspi-134509	194	42	their	their	PRON
ajbspi-134509	194	43	survival	survival	NOUN
ajbspi-134509	194	44	and	and	CCONJ
ajbspi-134509	194	45	propagation	propagation	NOUN
ajbspi-134509	194	46	.	.	PUNCT
ajbspi-134509	195	1	conclusion	conclusion	NOUN
ajbspi-134509	195	2	the	the	DET
ajbspi-134509	195	3	host	host	NOUN
ajbspi-134509	195	4	adenosine	adenosine	NOUN
ajbspi-134509	195	5	system	system	NOUN
ajbspi-134509	195	6	,	,	PUNCT
ajbspi-134509	195	7	a	a	DET
ajbspi-134509	195	8	critical	critical	ADJ
ajbspi-134509	195	9	modulator	modulator	NOUN
ajbspi-134509	195	10	of	of	ADP
ajbspi-134509	195	11	inflammation	inflammation	NOUN
ajbspi-134509	195	12	and	and	CCONJ
ajbspi-134509	195	13	tissue	tissue	NOUN
ajbspi-134509	195	14	homeostasis	homeostasis	NOUN
ajbspi-134509	195	15	,	,	PUNCT
ajbspi-134509	195	16	presents	present	VERB
ajbspi-134509	195	17	a	a	DET
ajbspi-134509	195	18	compelling	compelling	ADJ
ajbspi-134509	195	19	arena	arena	NOUN
ajbspi-134509	195	20	for	for	ADP
ajbspi-134509	195	21	understanding	understand	VERB
ajbspi-134509	195	22	the	the	DET
ajbspi-134509	195	23	nuanced	nuanced	ADJ
ajbspi-134509	195	24	strategies	strategy	NOUN
ajbspi-134509	195	25	employed	employ	VERB
ajbspi-134509	195	26	by	by	ADP
ajbspi-134509	195	27	pathogens	pathogen	NOUN
ajbspi-134509	195	28	like	like	ADP
ajbspi-134509	195	29	clostridioides	clostridioide	NOUN
ajbspi-134509	195	30	difficile	difficile	VERB
ajbspi-134509	195	31	to	to	PART
ajbspi-134509	195	32	establish	establish	VERB
ajbspi-134509	195	33	and	and	CCONJ
ajbspi-134509	195	34	perpetuate	perpetuate	VERB
ajbspi-134509	195	35	infection	infection	NOUN
ajbspi-134509	195	36	.	.	PUNCT
ajbspi-134509	196	1	this	this	DET
ajbspi-134509	196	2	review	review	NOUN
ajbspi-134509	196	3	has	have	AUX
ajbspi-134509	196	4	meticulously	meticulously	ADV
ajbspi-134509	196	5	detailed	detail	VERB
ajbspi-134509	196	6	the	the	DET
ajbspi-134509	196	7	generation	generation	NOUN
ajbspi-134509	196	8	and	and	CCONJ
ajbspi-134509	196	9	metabolism	metabolism	NOUN
ajbspi-134509	196	10	of	of	ADP
ajbspi-134509	196	11	adenosine	adenosine	NOUN
ajbspi-134509	196	12	through	through	ADP
ajbspi-134509	196	13	the	the	DET
ajbspi-134509	196	14	ectonucleotidases	ectonucleotidase	NOUN
ajbspi-134509	196	15	cd39	cd39	PROPN
ajbspi-134509	196	16	and	and	CCONJ
ajbspi-134509	196	17	cd73	cd73	PROPN
ajbspi-134509	196	18	,	,	PUNCT
ajbspi-134509	196	19	highlighting	highlight	VERB
ajbspi-134509	196	20	its	its	PRON
ajbspi-134509	196	21	profound	profound	ADJ
ajbspi-134509	196	22	immunosuppressive	immunosuppressive	ADJ
ajbspi-134509	196	23	effects	effect	NOUN
ajbspi-134509	196	24	mediated	mediate	VERB
ajbspi-134509	196	25	via	via	ADP
ajbspi-134509	196	26	specific	specific	ADJ
ajbspi-134509	196	27	adenosine	adenosine	NOUN
ajbspi-134509	196	28	receptors	receptor	NOUN
ajbspi-134509	196	29	on	on	ADP
ajbspi-134509	196	30	a	a	DET
ajbspi-134509	196	31	diverse	diverse	ADJ
ajbspi-134509	196	32	array	array	NOUN
ajbspi-134509	196	33	of	of	ADP
ajbspi-134509	196	34	immune	immune	ADJ
ajbspi-134509	196	35	cells	cell	NOUN
ajbspi-134509	196	36	,	,	PUNCT
ajbspi-134509	196	37	including	include	VERB
ajbspi-134509	196	38	neutrophils	neutrophil	NOUN
ajbspi-134509	196	39	,	,	PUNCT
ajbspi-134509	196	40	macrophages	macrophage	NOUN
ajbspi-134509	196	41	,	,	PUNCT
ajbspi-134509	196	42	dendritic	dendritic	ADJ
ajbspi-134509	196	43	cells	cell	NOUN
ajbspi-134509	196	44	,	,	PUNCT
ajbspi-134509	196	45	and	and	CCONJ
ajbspi-134509	196	46	t	t	NOUN
ajbspi-134509	196	47	cells	cell	NOUN
ajbspi-134509	196	48	.	.	PUNCT
ajbspi-134509	197	1	in	in	ADP
ajbspi-134509	197	2	the	the	DET
ajbspi-134509	197	3	context	context	NOUN
ajbspi-134509	197	4	of	of	ADP
ajbspi-134509	197	5	c.	c.	NOUN
ajbspi-134509	197	6	difficile	difficile	PROPN
ajbspi-134509	197	7	infection	infection	NOUN
ajbspi-134509	197	8	,	,	PUNCT
ajbspi-134509	197	9	the	the	DET
ajbspi-134509	197	10	severe	severe	ADJ
ajbspi-134509	197	11	gut	gut	NOUN
ajbspi-134509	197	12	inflammation	inflammation	NOUN
ajbspi-134509	197	13	and	and	CCONJ
ajbspi-134509	197	14	cellular	cellular	ADJ
ajbspi-134509	197	15	damage	damage	NOUN
ajbspi-134509	197	16	induced	induce	VERB
ajbspi-134509	197	17	by	by	ADP
ajbspi-134509	197	18	bacterial	bacterial	ADJ
ajbspi-134509	197	19	toxins	toxin	NOUN
ajbspi-134509	197	20	lead	lead	VERB
ajbspi-134509	197	21	to	to	ADP
ajbspi-134509	197	22	a	a	DET
ajbspi-134509	197	23	significant	significant	ADJ
ajbspi-134509	197	24	release	release	NOUN
ajbspi-134509	197	25	of	of	ADP
ajbspi-134509	197	26	atp	atp	PROPN
ajbspi-134509	197	27	,	,	PUNCT
ajbspi-134509	197	28	a	a	DET
ajbspi-134509	197	29	proinflammatory	proinflammatory	ADJ
ajbspi-134509	197	30	damp	damp	NOUN
ajbspi-134509	197	31	.	.	PUNCT
ajbspi-134509	198	1	this	this	DET
ajbspi-134509	198	2	atp	atp	PROPN
ajbspi-134509	198	3	is	be	AUX
ajbspi-134509	198	4	then	then	ADV
ajbspi-134509	198	5	rapidly	rapidly	ADV
ajbspi-134509	198	6	converted	convert	VERB
ajbspi-134509	198	7	to	to	PART
ajbspi-134509	198	8	adenosine	adenosine	VERB
ajbspi-134509	198	9	by	by	ADP
ajbspi-134509	198	10	the	the	DET
ajbspi-134509	198	11	host	host	NOUN
ajbspi-134509	198	12	's	's	PART
ajbspi-134509	198	13	own	own	ADJ
ajbspi-134509	198	14	enzymatic	enzymatic	ADJ
ajbspi-134509	198	15	machinery	machinery	NOUN
ajbspi-134509	198	16	.	.	PUNCT
ajbspi-134509	199	1	we	we	PRON
ajbspi-134509	199	2	hypothesize	hypothesize	VERB
ajbspi-134509	199	3	that	that	SCONJ
ajbspi-134509	199	4	c.	c.	NOUN
ajbspi-134509	199	5	difficile	difficile	VERB
ajbspi-134509	199	6	indirectly	indirectly	ADV
ajbspi-134509	199	7	exploits	exploit	VERB
ajbspi-134509	199	8	this	this	DET
ajbspi-134509	199	9	host	host	NOUN
ajbspi-134509	199	10	homeostatic	homeostatic	ADJ
ajbspi-134509	199	11	mechanism	mechanism	NOUN
ajbspi-134509	199	12	,	,	PUNCT
ajbspi-134509	199	13	leveraging	leverage	VERB
ajbspi-134509	199	14	the	the	DET
ajbspi-134509	199	15	resulting	result	VERB
ajbspi-134509	199	16	adenosine	adenosine	ADJ
ajbspi-134509	199	17	-	-	PUNCT
ajbspi-134509	199	18	rich	rich	ADJ
ajbspi-134509	199	19	microenvironment	microenvironment	NOUN
ajbspi-134509	199	20	to	to	PART
ajbspi-134509	199	21	dampen	dampen	VERB
ajbspi-134509	199	22	effective	effective	ADJ
ajbspi-134509	199	23	immune	immune	ADJ
ajbspi-134509	199	24	responses	response	NOUN
ajbspi-134509	199	25	.	.	PUNCT
ajbspi-134509	200	1	this	this	DET
ajbspi-134509	200	2	adenosine	adenosine	NOUN
ajbspi-134509	200	3	-	-	PUNCT
ajbspi-134509	200	4	mediated	mediate	VERB
ajbspi-134509	200	5	immunosuppression	immunosuppression	NOUN
ajbspi-134509	200	6	could	could	AUX
ajbspi-134509	200	7	manifest	manifest	VERB
ajbspi-134509	200	8	as	as	ADP
ajbspi-134509	200	9	reduced	reduce	VERB
ajbspi-134509	200	10	neutrophil	neutrophil	ADJ
ajbspi-134509	200	11	recruitment	recruitment	NOUN
ajbspi-134509	200	12	,	,	PUNCT
ajbspi-134509	200	13	a	a	DET
ajbspi-134509	200	14	shift	shift	NOUN
ajbspi-134509	200	15	towards	towards	ADP
ajbspi-134509	200	16	antiinflammatory	antiinflammatory	NOUN
ajbspi-134509	200	17	macrophage	macrophage	ADJ
ajbspi-134509	200	18	phenotypes	phenotype	NOUN
ajbspi-134509	200	19	,	,	PUNCT
ajbspi-134509	200	20	impaired	impair	VERB
ajbspi-134509	200	21	dendritic	dendritic	ADJ
ajbspi-134509	200	22	cell	cell	NOUN
ajbspi-134509	200	23	activation	activation	NOUN
ajbspi-134509	200	24	,	,	PUNCT
ajbspi-134509	200	25	and	and	CCONJ
ajbspi-134509	200	26	suppression	suppression	NOUN
ajbspi-134509	200	27	of	of	ADP
ajbspi-134509	200	28	effector	effector	NOUN
ajbspi-134509	200	29	t	t	PROPN
ajbspi-134509	200	30	cell	cell	NOUN
ajbspi-134509	200	31	functions	function	NOUN
ajbspi-134509	200	32	,	,	PUNCT
ajbspi-134509	200	33	while	while	SCONJ
ajbspi-134509	200	34	potentially	potentially	ADV
ajbspi-134509	200	35	promoting	promote	VERB
ajbspi-134509	200	36	the	the	DET
ajbspi-134509	200	37	activity	activity	NOUN
ajbspi-134509	200	38	of	of	ADP
ajbspi-134509	200	39	regulatory	regulatory	ADJ
ajbspi-134509	200	40	t	t	NOUN
ajbspi-134509	200	41	cells	cell	NOUN
ajbspi-134509	200	42	and	and	CCONJ
ajbspi-134509	200	43	myeloid	myeloid	NOUN
ajbspi-134509	200	44	-	-	PUNCT
ajbspi-134509	200	45	derived	derive	VERB
ajbspi-134509	200	46	suppressor	suppressor	NOUN
ajbspi-134509	200	47	american	american	PROPN
ajbspi-134509	200	48	journal	journal	PROPN
ajbspi-134509	200	49	of	of	ADP
ajbspi-134509	200	50	applied	apply	VERB
ajbspi-134509	200	51	science	science	NOUN
ajbspi-134509	200	52	and	and	CCONJ
ajbspi-134509	200	53	technology	technology	NOUN
ajbspi-134509	200	54	8	8	NUM
ajbspi-134509	200	55	https://theusajournals.com/index.php/ajast	https://theusajournals.com/index.php/ajast	VERB
ajbspi-134509	200	56	american	american	PROPN
ajbspi-134509	200	57	journal	journal	PROPN
ajbspi-134509	200	58	of	of	ADP
ajbspi-134509	200	59	applied	apply	VERB
ajbspi-134509	200	60	science	science	NOUN
ajbspi-134509	200	61	and	and	CCONJ
ajbspi-134509	200	62	technology	technology	NOUN
ajbspi-134509	200	63	(	(	PUNCT
ajbspi-134509	200	64	issn	issn	PROPN
ajbspi-134509	200	65	:	:	PUNCT
ajbspi-134509	200	66	2771	2771	NUM
ajbspi-134509	200	67	-	-	SYM
ajbspi-134509	200	68	2745	2745	NUM
ajbspi-134509	200	69	)	)	PUNCT
ajbspi-134509	200	70	cells	cell	NOUN
ajbspi-134509	200	71	.	.	PUNCT
ajbspi-134509	201	1	such	such	ADJ
ajbspi-134509	201	2	manipulation	manipulation	NOUN
ajbspi-134509	201	3	would	would	AUX
ajbspi-134509	201	4	create	create	VERB
ajbspi-134509	201	5	an	an	DET
ajbspi-134509	201	6	immunetolerant	immunetolerant	ADJ
ajbspi-134509	201	7	niche	niche	NOUN
ajbspi-134509	201	8	,	,	PUNCT
ajbspi-134509	201	9	facilitating	facilitate	VERB
ajbspi-134509	201	10	c.	c.	NOUN
ajbspi-134509	201	11	difficile	difficile	PROPN
ajbspi-134509	201	12	colonization	colonization	NOUN
ajbspi-134509	201	13	,	,	PUNCT
ajbspi-134509	201	14	persistence	persistence	NOUN
ajbspi-134509	201	15	,	,	PUNCT
ajbspi-134509	201	16	and	and	CCONJ
ajbspi-134509	201	17	contributing	contribute	VERB
ajbspi-134509	201	18	to	to	ADP
ajbspi-134509	201	19	disease	disease	NOUN
ajbspi-134509	201	20	severity	severity	NOUN
ajbspi-134509	201	21	and	and	CCONJ
ajbspi-134509	201	22	recurrence	recurrence	NOUN
ajbspi-134509	201	23	.	.	PUNCT
ajbspi-134509	202	1	understanding	understand	VERB
ajbspi-134509	202	2	this	this	DET
ajbspi-134509	202	3	microbial	microbial	ADJ
ajbspi-134509	202	4	exploitation	exploitation	NOUN
ajbspi-134509	202	5	of	of	ADP
ajbspi-134509	202	6	host	host	NOUN
ajbspi-134509	202	7	purinergic	purinergic	NOUN
ajbspi-134509	202	8	signaling	signal	VERB
ajbspi-134509	202	9	opens	open	VERB
ajbspi-134509	202	10	exciting	exciting	ADJ
ajbspi-134509	202	11	new	new	ADJ
ajbspi-134509	202	12	avenues	avenue	NOUN
ajbspi-134509	202	13	for	for	ADP
ajbspi-134509	202	14	therapeutic	therapeutic	ADJ
ajbspi-134509	202	15	intervention	intervention	NOUN
ajbspi-134509	202	16	.	.	PUNCT
ajbspi-134509	203	1	targeting	target	VERB
ajbspi-134509	203	2	the	the	DET
ajbspi-134509	203	3	adenosine	adenosine	ADJ
ajbspi-134509	203	4	pathway	pathway	NOUN
ajbspi-134509	203	5	,	,	PUNCT
ajbspi-134509	203	6	for	for	ADP
ajbspi-134509	203	7	instance	instance	NOUN
ajbspi-134509	203	8	,	,	PUNCT
ajbspi-134509	203	9	through	through	ADP
ajbspi-134509	203	10	the	the	DET
ajbspi-134509	203	11	use	use	NOUN
ajbspi-134509	203	12	of	of	ADP
ajbspi-134509	203	13	adenosine	adenosine	ADJ
ajbspi-134509	203	14	receptor	receptor	NOUN
ajbspi-134509	203	15	antagonists	antagonist	NOUN
ajbspi-134509	203	16	or	or	CCONJ
ajbspi-134509	203	17	ectonucleotidase	ectonucleotidase	ADJ
ajbspi-134509	203	18	inhibitors	inhibitor	NOUN
ajbspi-134509	203	19	,	,	PUNCT
ajbspi-134509	203	20	could	could	AUX
ajbspi-134509	203	21	represent	represent	VERB
ajbspi-134509	203	22	a	a	DET
ajbspi-134509	203	23	novel	novel	ADJ
ajbspi-134509	203	24	adjunctive	adjunctive	ADJ
ajbspi-134509	203	25	strategy	strategy	NOUN
ajbspi-134509	203	26	to	to	PART
ajbspi-134509	203	27	bolster	bolster	VERB
ajbspi-134509	203	28	host	host	NOUN
ajbspi-134509	203	29	immunity	immunity	NOUN
ajbspi-134509	203	30	and	and	CCONJ
ajbspi-134509	203	31	improve	improve	VERB
ajbspi-134509	203	32	outcomes	outcome	NOUN
ajbspi-134509	203	33	in	in	ADP
ajbspi-134509	203	34	cdi	cdi	PROPN
ajbspi-134509	203	35	.	.	PUNCT
ajbspi-134509	204	1	while	while	SCONJ
ajbspi-134509	204	2	direct	direct	ADJ
ajbspi-134509	204	3	evidence	evidence	NOUN
ajbspi-134509	204	4	of	of	ADP
ajbspi-134509	204	5	c.	c.	PROPN
ajbspi-134509	204	6	difficile	difficile	PROPN
ajbspi-134509	204	7	's	's	PART
ajbspi-134509	204	8	specific	specific	ADJ
ajbspi-134509	204	9	manipulation	manipulation	NOUN
ajbspi-134509	204	10	mechanisms	mechanism	NOUN
ajbspi-134509	204	11	requires	require	VERB
ajbspi-134509	204	12	further	further	ADJ
ajbspi-134509	204	13	investigation	investigation	NOUN
ajbspi-134509	204	14	,	,	PUNCT
ajbspi-134509	204	15	the	the	DET
ajbspi-134509	204	16	established	establish	VERB
ajbspi-134509	204	17	roles	role	NOUN
ajbspi-134509	204	18	of	of	ADP
ajbspi-134509	204	19	adenosine	adenosine	NOUN
ajbspi-134509	204	20	in	in	ADP
ajbspi-134509	204	21	immune	immune	ADJ
ajbspi-134509	204	22	regulation	regulation	NOUN
ajbspi-134509	204	23	provide	provide	VERB
ajbspi-134509	204	24	a	a	DET
ajbspi-134509	204	25	strong	strong	ADJ
ajbspi-134509	204	26	theoretical	theoretical	ADJ
ajbspi-134509	204	27	basis	basis	NOUN
ajbspi-134509	204	28	for	for	ADP
ajbspi-134509	204	29	this	this	DET
ajbspi-134509	204	30	hypothesis	hypothesis	NOUN
ajbspi-134509	204	31	.	.	PUNCT
ajbspi-134509	205	1	future	future	ADJ
ajbspi-134509	205	2	research	research	NOUN
ajbspi-134509	205	3	should	should	AUX
ajbspi-134509	205	4	prioritize	prioritize	VERB
ajbspi-134509	205	5	direct	direct	ADJ
ajbspi-134509	205	6	experimental	experimental	ADJ
ajbspi-134509	205	7	validation	validation	NOUN
ajbspi-134509	205	8	of	of	ADP
ajbspi-134509	205	9	these	these	DET
ajbspi-134509	205	10	proposed	propose	VERB
ajbspi-134509	205	11	interactions	interaction	NOUN
ajbspi-134509	205	12	,	,	PUNCT
ajbspi-134509	205	13	paving	pave	VERB
ajbspi-134509	205	14	the	the	DET
ajbspi-134509	205	15	way	way	NOUN
ajbspi-134509	205	16	for	for	ADP
ajbspi-134509	205	17	innovative	innovative	ADJ
ajbspi-134509	205	18	host	host	NOUN
ajbspi-134509	205	19	-	-	PUNCT
ajbspi-134509	205	20	directed	direct	VERB
ajbspi-134509	205	21	therapies	therapy	NOUN
ajbspi-134509	205	22	that	that	PRON
ajbspi-134509	205	23	complement	complement	VERB
ajbspi-134509	205	24	traditional	traditional	ADJ
ajbspi-134509	205	25	antimicrobial	antimicrobial	ADJ
ajbspi-134509	205	26	approaches	approach	NOUN
ajbspi-134509	205	27	,	,	PUNCT
ajbspi-134509	205	28	ultimately	ultimately	ADV
ajbspi-134509	205	29	enhancing	enhance	VERB
ajbspi-134509	205	30	our	our	PRON
ajbspi-134509	205	31	ability	ability	NOUN
ajbspi-134509	205	32	to	to	PART
ajbspi-134509	205	33	combat	combat	VERB
ajbspi-134509	205	34	this	this	DET
ajbspi-134509	205	35	challenging	challenging	ADJ
ajbspi-134509	205	36	pathogen	pathogen	NOUN
ajbspi-134509	205	37	and	and	CCONJ
ajbspi-134509	205	38	potentially	potentially	ADV
ajbspi-134509	205	39	other	other	ADJ
ajbspi-134509	205	40	inflammatory	inflammatory	ADJ
ajbspi-134509	205	41	infectious	infectious	ADJ
ajbspi-134509	205	42	diseases	disease	NOUN
ajbspi-134509	205	43	.	.	PUNCT
ajbspi-134509	206	1	references	reference	NOUN
ajbspi-134509	206	2	fredholm	fredholm	VERB
ajbspi-134509	206	3	bb	bb	PROPN
ajbspi-134509	206	4	.	.	PUNCT
ajbspi-134509	206	5	adenosine	adenosine	NOUN
ajbspi-134509	206	6	,	,	PUNCT
ajbspi-134509	206	7	an	an	DET
ajbspi-134509	206	8	endogenous	endogenous	ADJ
ajbspi-134509	206	9	distress	distress	NOUN
ajbspi-134509	206	10	signal	signal	NOUN
ajbspi-134509	206	11	,	,	PUNCT
ajbspi-134509	206	12	modulates	modulate	VERB
ajbspi-134509	206	13	tissue	tissue	NOUN
ajbspi-134509	206	14	damage	damage	NOUN
ajbspi-134509	206	15	and	and	CCONJ
ajbspi-134509	206	16	repair	repair	NOUN
ajbspi-134509	206	17	.	.	PUNCT
ajbspi-134509	207	1	cell	cell	NOUN
ajbspi-134509	207	2	death	death	NOUN
ajbspi-134509	207	3	differ	differ	VERB
ajbspi-134509	207	4	.	.	PUNCT
ajbspi-134509	208	1	2007;14:1315–23	2007;14:1315–23	X
ajbspi-134509	208	2	.	.	PUNCT
ajbspi-134509	209	1	mehta	mehta	PROPN
ajbspi-134509	209	2	tr	tr	VERB
ajbspi-134509	209	3	,	,	PUNCT
ajbspi-134509	209	4	murala	murala	NOUN
ajbspi-134509	209	5	s	s	NOUN
ajbspi-134509	209	6	,	,	PUNCT
ajbspi-134509	209	7	thakkar	thakkar	NOUN
ajbspi-134509	209	8	mm	mm	PROPN
ajbspi-134509	209	9	.	.	PUNCT
ajbspi-134509	209	10	adenosine	adenosine	PROPN
ajbspi-134509	209	11	.	.	PUNCT
ajbspi-134509	210	1	cham	cham	PROPN
ajbspi-134509	210	2	:	:	PUNCT
ajbspi-134509	210	3	springer	springer	NOUN
ajbspi-134509	210	4	international	international	ADJ
ajbspi-134509	210	5	publishing	publishing	NOUN
ajbspi-134509	210	6	;	;	PUNCT
ajbspi-134509	210	7	2022	2022	NUM
ajbspi-134509	210	8	.	.	PUNCT
ajbspi-134509	211	1	borea	borea	PROPN
ajbspi-134509	211	2	pa	pa	PROPN
ajbspi-134509	211	3	,	,	PUNCT
ajbspi-134509	211	4	gessi	gessi	PROPN
ajbspi-134509	211	5	s	s	PROPN
ajbspi-134509	211	6	,	,	PUNCT
ajbspi-134509	211	7	merighi	merighi	PROPN
ajbspi-134509	211	8	s	s	PROPN
ajbspi-134509	211	9	,	,	PUNCT
ajbspi-134509	211	10	vincenzi	vincenzi	PROPN
ajbspi-134509	211	11	f	f	PROPN
ajbspi-134509	211	12	,	,	PUNCT
ajbspi-134509	211	13	varani	varani	PROPN
ajbspi-134509	211	14	k.	k.	PROPN
ajbspi-134509	211	15	pharmacology	pharmacology	PROPN
ajbspi-134509	211	16	of	of	ADP
ajbspi-134509	211	17	adenosine	adenosine	ADJ
ajbspi-134509	211	18	receptors	receptor	NOUN
ajbspi-134509	211	19	:	:	PUNCT
ajbspi-134509	211	20	the	the	DET
ajbspi-134509	211	21	state	state	NOUN
ajbspi-134509	211	22	of	of	ADP
ajbspi-134509	211	23	the	the	DET
ajbspi-134509	211	24	art	art	NOUN
ajbspi-134509	211	25	.	.	PUNCT
ajbspi-134509	212	1	physiol	physiol	PROPN
ajbspi-134509	212	2	rev	rev	VERB
ajbspi-134509	212	3	.	.	PUNCT
ajbspi-134509	213	1	2018;98:1591–625	2018;98:1591–625	NOUN
ajbspi-134509	213	2	.	.	PUNCT
ajbspi-134509	214	1	https://doi.org/10.1152/physrev.00049.2017	https://doi.org/10.1152/physrev.00049.2017	PROPN
ajbspi-134509	214	2	.	.	PUNCT
ajbspi-134509	214	3	layland	layland	PROPN
ajbspi-134509	214	4	j	j	PROPN
ajbspi-134509	214	5	,	,	PUNCT
ajbspi-134509	214	6	carrick	carrick	PROPN
ajbspi-134509	214	7	d	d	PROPN
ajbspi-134509	214	8	,	,	PUNCT
ajbspi-134509	214	9	lee	lee	PROPN
ajbspi-134509	214	10	m	m	PROPN
ajbspi-134509	214	11	,	,	PUNCT
ajbspi-134509	214	12	oldroyd	oldroyd	VERB
ajbspi-134509	214	13	k	k	X
ajbspi-134509	214	14	,	,	PUNCT
ajbspi-134509	214	15	berry	berry	VERB
ajbspi-134509	214	16	c.	c.	NOUN
ajbspi-134509	214	17	adenosine	adenosine	NOUN
ajbspi-134509	214	18	.	.	PUNCT
ajbspi-134509	215	1	jacc	jacc	PROPN
ajbspi-134509	215	2	cardiovasc	cardiovasc	PROPN
ajbspi-134509	215	3	interv	interv	VERB
ajbspi-134509	215	4	.	.	PUNCT
ajbspi-134509	216	1	2014;7:581–91	2014;7:581–91	NUM
ajbspi-134509	216	2	.	.	PUNCT
ajbspi-134509	217	1	camici	camici	PROPN
ajbspi-134509	217	2	m	m	PROPN
ajbspi-134509	217	3	,	,	PUNCT
ajbspi-134509	217	4	garcia	garcia	PROPN
ajbspi-134509	217	5	-	-	PUNCT
ajbspi-134509	217	6	gil	gil	PROPN
ajbspi-134509	217	7	m	m	PROPN
ajbspi-134509	217	8	,	,	PUNCT
ajbspi-134509	217	9	tozzi	tozzi	PROPN
ajbspi-134509	217	10	m.	m.	NOUN
ajbspi-134509	217	11	the	the	DET
ajbspi-134509	217	12	inside	inside	ADJ
ajbspi-134509	217	13	story	story	NOUN
ajbspi-134509	217	14	of	of	ADP
ajbspi-134509	217	15	adenosine	adenosine	NOUN
ajbspi-134509	217	16	.	.	PUNCT
ajbspi-134509	218	1	int	int	PROPN
ajbspi-134509	218	2	j	j	PROPN
ajbspi-134509	218	3	mol	mol	ADP
ajbspi-134509	218	4	sci	sci	PROPN
ajbspi-134509	218	5	.	.	PUNCT
ajbspi-134509	219	1	2018;19:784	2018;19:784	PROPN
ajbspi-134509	219	2	.	.	PUNCT
ajbspi-134509	220	1	yegutkin	yegutkin	PROPN
ajbspi-134509	220	2	gg	gg	PROPN
ajbspi-134509	220	3	.	.	PROPN
ajbspi-134509	220	4	nucleotideand	nucleotideand	NOUN
ajbspi-134509	220	5	nucleoside	nucleoside	ADV
ajbspi-134509	220	6	-	-	PUNCT
ajbspi-134509	220	7	converting	convert	VERB
ajbspi-134509	220	8	ectoenzymes	ectoenzyme	NOUN
ajbspi-134509	220	9	:	:	PUNCT
ajbspi-134509	220	10	important	important	ADJ
ajbspi-134509	220	11	modulators	modulator	NOUN
ajbspi-134509	220	12	of	of	ADP
ajbspi-134509	220	13	purinergic	purinergic	NOUN
ajbspi-134509	220	14	signalling	signal	VERB
ajbspi-134509	220	15	cascade	cascade	NOUN
ajbspi-134509	220	16	.	.	PUNCT
ajbspi-134509	221	1	biochim	biochim	PROPN
ajbspi-134509	221	2	biophys	biophy	NOUN
ajbspi-134509	221	3	acta	acta	PROPN
ajbspi-134509	221	4	mol	mol	ADP
ajbspi-134509	221	5	cell	cell	NOUN
ajbspi-134509	221	6	res	re	NOUN
ajbspi-134509	221	7	.	.	PUNCT
ajbspi-134509	222	1	2008;1783:673–94	2008;1783:673–94	NUM
ajbspi-134509	222	2	.	.	PUNCT
ajbspi-134509	223	1	robson	robson	PROPN
ajbspi-134509	223	2	sc	sc	PROPN
ajbspi-134509	223	3	,	,	PUNCT
ajbspi-134509	223	4	wu	wu	PROPN
ajbspi-134509	223	5	y	y	PROPN
ajbspi-134509	223	6	,	,	PUNCT
ajbspi-134509	223	7	sun	sun	PROPN
ajbspi-134509	223	8	x	x	SYM
ajbspi-134509	223	9	,	,	PUNCT
ajbspi-134509	223	10	knosalla	knosalla	NOUN
ajbspi-134509	223	11	c	c	PROPN
ajbspi-134509	223	12	,	,	PUNCT
ajbspi-134509	223	13	dwyer	dwyer	PROPN
ajbspi-134509	223	14	k	k	PROPN
ajbspi-134509	223	15	,	,	PUNCT
ajbspi-134509	223	16	enjyoji	enjyoji	PROPN
ajbspi-134509	223	17	k.	k.	PROPN
ajbspi-134509	223	18	ectonucleotidases	ectonucleotidase	NOUN
ajbspi-134509	223	19	of	of	ADP
ajbspi-134509	223	20	cd39	cd39	PROPN
ajbspi-134509	223	21	family	family	NOUN
ajbspi-134509	223	22	modulate	modulate	VERB
ajbspi-134509	223	23	vascular	vascular	ADJ
ajbspi-134509	223	24	inflammation	inflammation	NOUN
ajbspi-134509	223	25	and	and	CCONJ
ajbspi-134509	223	26	thrombosis	thrombosis	NOUN
ajbspi-134509	223	27	in	in	ADP
ajbspi-134509	223	28	transplantation	transplantation	NOUN
ajbspi-134509	223	29	.	.	PUNCT
ajbspi-134509	224	1	semin	semin	PROPN
ajbspi-134509	224	2	thromb	thromb	PROPN
ajbspi-134509	224	3	hemost	hemost	PROPN
ajbspi-134509	224	4	.	.	PUNCT
ajbspi-134509	225	1	2005;31:217–33	2005;31:217–33	X
ajbspi-134509	225	2	.	.	PUNCT
ajbspi-134509	225	3	https://doi.org/10.1055/s-2005-869527	https://doi.org/10.1055/s-2005-869527	PROPN
ajbspi-134509	225	4	.	.	PUNCT
ajbspi-134509	226	1	picher	picher	PROPN
ajbspi-134509	226	2	m	m	PROPN
ajbspi-134509	226	3	,	,	PUNCT
ajbspi-134509	226	4	burch	burch	PROPN
ajbspi-134509	226	5	lh	lh	PROPN
ajbspi-134509	226	6	,	,	PUNCT
ajbspi-134509	226	7	hirsh	hirsh	PROPN
ajbspi-134509	226	8	aj	aj	PROPN
ajbspi-134509	226	9	,	,	PUNCT
ajbspi-134509	226	10	spychala	spychala	PROPN
ajbspi-134509	226	11	j	j	PROPN
ajbspi-134509	226	12	,	,	PUNCT
ajbspi-134509	226	13	boucher	boucher	PROPN
ajbspi-134509	226	14	rc	rc	PROPN
ajbspi-134509	226	15	.	.	PUNCT
ajbspi-134509	227	1	ecto	ecto	PROPN
ajbspi-134509	227	2	5′-nucleotidase	5′-nucleotidase	NUM
ajbspi-134509	227	3	and	and	CCONJ
ajbspi-134509	227	4	nonspecific	nonspecific	ADJ
ajbspi-134509	227	5	alkaline	alkaline	NOUN
ajbspi-134509	227	6	phosphatase	phosphatase	NOUN
ajbspi-134509	227	7	:	:	PUNCT
ajbspi-134509	227	8	two	two	NUM
ajbspi-134509	227	9	amp	amp	NOUN
ajbspi-134509	227	10	-	-	PUNCT
ajbspi-134509	227	11	hydrolyzing	hydrolyze	VERB
ajbspi-134509	227	12	ectoenzymes	ectoenzyme	NOUN
ajbspi-134509	227	13	with	with	ADP
ajbspi-134509	227	14	distinct	distinct	ADJ
ajbspi-134509	227	15	roles	role	NOUN
ajbspi-134509	227	16	in	in	ADP
ajbspi-134509	227	17	human	human	ADJ
ajbspi-134509	227	18	airways	airway	NOUN
ajbspi-134509	227	19	.	.	PUNCT
ajbspi-134509	228	1	j	j	PROPN
ajbspi-134509	228	2	biol	biol	PROPN
ajbspi-134509	228	3	chem	chem	NOUN
ajbspi-134509	228	4	.	.	PUNCT
ajbspi-134509	229	1	2003;278:13468–79	2003;278:13468–79	ADJ
ajbspi-134509	229	2	.	.	PUNCT
ajbspi-134509	230	1	https://doi.org/10.1074/jbc.m300569200	https://doi.org/10.1074/jbc.m300569200	X
ajbspi-134509	230	2	.	.	PUNCT
ajbspi-134509	231	1	young	young	PROPN
ajbspi-134509	231	2	jd	jd	PROPN
ajbspi-134509	231	3	,	,	PUNCT
ajbspi-134509	231	4	yao	yao	PROPN
ajbspi-134509	231	5	sym	sym	PROPN
ajbspi-134509	231	6	,	,	PUNCT
ajbspi-134509	231	7	baldwin	baldwin	PROPN
ajbspi-134509	231	8	jm	jm	PROPN
ajbspi-134509	231	9	,	,	PUNCT
ajbspi-134509	231	10	cass	cass	PROPN
ajbspi-134509	231	11	ce	ce	PROPN
ajbspi-134509	231	12	,	,	PUNCT
ajbspi-134509	231	13	baldwin	baldwin	PROPN
ajbspi-134509	231	14	sa	sa	PROPN
ajbspi-134509	231	15	.	.	PUNCT
ajbspi-134509	232	1	the	the	DET
ajbspi-134509	232	2	human	human	PROPN
ajbspi-134509	232	3	concentrative	concentrative	NOUN
ajbspi-134509	232	4	and	and	CCONJ
ajbspi-134509	232	5	equilibrative	equilibrative	ADJ
ajbspi-134509	232	6	nucleoside	nucleoside	NOUN
ajbspi-134509	232	7	transporter	transporter	NOUN
ajbspi-134509	232	8	families	family	NOUN
ajbspi-134509	232	9	,	,	PUNCT
ajbspi-134509	232	10	slc28	slc28	NOUN
ajbspi-134509	232	11	and	and	CCONJ
ajbspi-134509	232	12	slc29	slc29	ADJ
ajbspi-134509	232	13	.	.	PUNCT
ajbspi-134509	233	1	mol	mol	ADP
ajbspi-134509	233	2	aspects	aspect	NOUN
ajbspi-134509	233	3	med	me	VERB
ajbspi-134509	233	4	.	.	PUNCT
ajbspi-134509	234	1	2013;34:529–47	2013;34:529–47	X
ajbspi-134509	234	2	.	.	PUNCT
ajbspi-134509	235	1	https://doi.org/10.1016/j.mam.2012.05.007	https://doi.org/10.1016/j.mam.2012.05.007	VERB
ajbspi-134509	235	2	.	.	PUNCT
ajbspi-134509	236	1	vecchio	vecchio	PROPN
ajbspi-134509	236	2	ea	ea	PROPN
ajbspi-134509	236	3	,	,	PUNCT
ajbspi-134509	236	4	white	white	PROPN
ajbspi-134509	236	5	pj	pj	PROPN
ajbspi-134509	236	6	,	,	PUNCT
ajbspi-134509	236	7	may	may	AUX
ajbspi-134509	236	8	lt	lt	PROPN
ajbspi-134509	236	9	.	.	PUNCT
ajbspi-134509	237	1	the	the	DET
ajbspi-134509	237	2	adenosine	adenosine	ADJ
ajbspi-134509	237	3	a2b	a2b	PROPN
ajbspi-134509	237	4	g	g	NOUN
ajbspi-134509	237	5	protein	protein	NOUN
ajbspi-134509	237	6	-	-	PUNCT
ajbspi-134509	237	7	coupled	couple	VERB
ajbspi-134509	237	8	receptor	receptor	NOUN
ajbspi-134509	237	9	:	:	PUNCT
ajbspi-134509	237	10	recent	recent	ADJ
ajbspi-134509	237	11	advances	advance	NOUN
ajbspi-134509	237	12	and	and	CCONJ
ajbspi-134509	237	13	therapeutic	therapeutic	ADJ
ajbspi-134509	237	14	implications	implication	NOUN
ajbspi-134509	237	15	.	.	PUNCT
ajbspi-134509	238	1	pharmacol	pharmacol	VERB
ajbspi-134509	238	2	ther	ther	ADV
ajbspi-134509	238	3	.	.	PUNCT
ajbspi-134509	239	1	2019;198:20–33	2019;198:20–33	X
ajbspi-134509	239	2	.	.	PUNCT
ajbspi-134509	240	1	https://doi.org/10.1016/j.pharmthera.2019.01.003	https://doi.org/10.1016/j.pharmthera.2019.01.003	PROPN
ajbspi-134509	240	2	.	.	PUNCT
ajbspi-134509	241	1	burnstock	burnstock	PROPN
ajbspi-134509	241	2	g.	g.	PROPN
ajbspi-134509	241	3	purine	purine	NOUN
ajbspi-134509	241	4	and	and	CCONJ
ajbspi-134509	241	5	purinergic	purinergic	NOUN
ajbspi-134509	241	6	receptors	receptor	NOUN
ajbspi-134509	241	7	.	.	PUNCT
ajbspi-134509	242	1	brain	brain	NOUN
ajbspi-134509	242	2	neurosci	neurosci	PROPN
ajbspi-134509	242	3	adv	adv	PROPN
ajbspi-134509	242	4	.	.	PUNCT
ajbspi-134509	242	5	2018;2:239821281881749	2018;2:239821281881749	NOUN
ajbspi-134509	242	6	.	.	PUNCT
ajbspi-134509	243	1	https://doi.org/10.1177/2398212818817494	https://doi.org/10.1177/2398212818817494	X
ajbspi-134509	243	2	.	.	PUNCT
ajbspi-134509	244	1	sheth	sheth	PROPN
ajbspi-134509	244	2	s	s	PROPN
ajbspi-134509	244	3	,	,	PUNCT
ajbspi-134509	244	4	brito	brito	PROPN
ajbspi-134509	244	5	r	r	PROPN
ajbspi-134509	244	6	,	,	PUNCT
ajbspi-134509	244	7	mukherjea	mukherjea	PROPN
ajbspi-134509	244	8	d	d	PROPN
ajbspi-134509	244	9	,	,	PUNCT
ajbspi-134509	244	10	rybak	rybak	PROPN
ajbspi-134509	244	11	l	l	PROPN
ajbspi-134509	244	12	,	,	PUNCT
ajbspi-134509	244	13	ramkumar	ramkumar	X
ajbspi-134509	244	14	v.	v.	ADP
ajbspi-134509	244	15	adenosine	adenosine	NOUN
ajbspi-134509	244	16	receptors	receptor	NOUN
ajbspi-134509	244	17	:	:	PUNCT
ajbspi-134509	244	18	expression	expression	NOUN
ajbspi-134509	244	19	,	,	PUNCT
ajbspi-134509	244	20	function	function	NOUN
ajbspi-134509	244	21	and	and	CCONJ
ajbspi-134509	244	22	regulation	regulation	NOUN
ajbspi-134509	244	23	.	.	PUNCT
ajbspi-134509	245	1	int	int	PROPN
ajbspi-134509	245	2	j	j	PROPN
ajbspi-134509	245	3	mol	mol	ADP
ajbspi-134509	245	4	sci	sci	PROPN
ajbspi-134509	245	5	.	.	PROPN
ajbspi-134509	246	1	2014;15:2024–52	2014;15:2024–52	NUM
ajbspi-134509	246	2	.	.	PUNCT
ajbspi-134509	246	3	antonioli	antonioli	PROPN
ajbspi-134509	246	4	l	l	NOUN
ajbspi-134509	246	5	,	,	PUNCT
ajbspi-134509	246	6	fornai	fornai	PROPN
ajbspi-134509	246	7	m	m	PROPN
ajbspi-134509	246	8	,	,	PUNCT
ajbspi-134509	246	9	blandizzi	blandizzi	PROPN
ajbspi-134509	246	10	c	c	NOUN
ajbspi-134509	246	11	,	,	PUNCT
ajbspi-134509	246	12	pacher	pacher	NOUN
ajbspi-134509	246	13	p	p	NOUN
ajbspi-134509	246	14	,	,	PUNCT
ajbspi-134509	246	15	haskó	haskó	PROPN
ajbspi-134509	246	16	g.	g.	NOUN
ajbspi-134509	246	17	adenosine	adenosine	NOUN
ajbspi-134509	246	18	signaling	signal	VERB
ajbspi-134509	246	19	and	and	CCONJ
ajbspi-134509	246	20	the	the	DET
ajbspi-134509	246	21	immune	immune	ADJ
ajbspi-134509	246	22	system	system	NOUN
ajbspi-134509	246	23	:	:	PUNCT
ajbspi-134509	246	24	when	when	SCONJ
ajbspi-134509	246	25	a	a	DET
ajbspi-134509	246	26	lot	lot	NOUN
ajbspi-134509	246	27	could	could	AUX
ajbspi-134509	246	28	be	be	AUX
ajbspi-134509	246	29	too	too	ADV
ajbspi-134509	246	30	much	much	ADJ
ajbspi-134509	246	31	.	.	PUNCT
ajbspi-134509	247	1	immunol	immunol	PROPN
ajbspi-134509	247	2	lett	lett	PROPN
ajbspi-134509	247	3	.	.	PUNCT
ajbspi-134509	248	1	2019;205:9–15	2019;205:9–15	NUM
ajbspi-134509	248	2	.	.	PUNCT
ajbspi-134509	249	1	https://doi.org/10.1016/j.imlet.2018.04.006	https://doi.org/10.1016/j.imlet.2018.04.006	PROPN
ajbspi-134509	249	2	.	.	PUNCT
ajbspi-134509	250	1	junger	junger	PROPN
ajbspi-134509	250	2	wg	wg	PROPN
ajbspi-134509	250	3	.	.	PUNCT
ajbspi-134509	251	1	immune	immune	ADJ
ajbspi-134509	251	2	cell	cell	NOUN
ajbspi-134509	251	3	regulation	regulation	NOUN
ajbspi-134509	251	4	by	by	ADP
ajbspi-134509	251	5	autocrine	autocrine	NOUN
ajbspi-134509	251	6	purinergic	purinergic	NOUN
ajbspi-134509	251	7	signalling	signal	VERB
ajbspi-134509	251	8	.	.	PUNCT
ajbspi-134509	252	1	nat	nat	PROPN
ajbspi-134509	252	2	rev	rev	PROPN
ajbspi-134509	252	3	immunol	immunol	NOUN
ajbspi-134509	252	4	.	.	PUNCT
ajbspi-134509	253	1	2011;11:201	2011;11:201	NUM
ajbspi-134509	253	2	–	–	PUNCT
ajbspi-134509	253	3	12	12	NUM
ajbspi-134509	253	4	.	.	PUNCT
ajbspi-134509	253	5	fredholm	fredholm	PROPN
ajbspi-134509	253	6	bb	bb	PROPN
ajbspi-134509	253	7	.	.	PROPN
ajbspi-134509	253	8	physiological	physiological	ADJ
ajbspi-134509	253	9	and	and	CCONJ
ajbspi-134509	253	10	pathophysiological	pathophysiological	ADJ
ajbspi-134509	253	11	roles	role	NOUN
ajbspi-134509	253	12	of	of	ADP
ajbspi-134509	253	13	adenosine	adenosine	NOUN
ajbspi-134509	253	14	.	.	PUNCT
ajbspi-134509	254	1	sleep	sleep	VERB
ajbspi-134509	254	2	biol	biol	NOUN
ajbspi-134509	254	3	rhythms	rhythm	NOUN
ajbspi-134509	254	4	.	.	PUNCT
ajbspi-134509	255	1	2011;9:24–8	2011;9:24–8	X
ajbspi-134509	255	2	.	.	PUNCT
ajbspi-134509	256	1	https://doi.org/10.1111/j.1479-8425.2010.00460.x	https://doi.org/10.1111/j.1479-8425.2010.00460.x	PROPN
ajbspi-134509	256	2	.	.	PUNCT
ajbspi-134509	257	1	https://doi.org/10.1152/physrev.00049.2017	https://doi.org/10.1152/physrev.00049.2017	PROPN
ajbspi-134509	257	2	https://doi.org/10.1152/physrev.00049.2017	https://doi.org/10.1152/physrev.00049.2017	PROPN
ajbspi-134509	257	3	https://doi.org/10.1055/s-2005-869527	https://doi.org/10.1055/s-2005-869527	NOUN
ajbspi-134509	257	4	https://doi.org/10.1055/s-2005-869527	https://doi.org/10.1055/s-2005-869527	PROPN
ajbspi-134509	257	5	https://doi.org/10.1074/jbc.m300569200	https://doi.org/10.1074/jbc.m300569200	X
ajbspi-134509	257	6	https://doi.org/10.1074/jbc.m300569200	https://doi.org/10.1074/jbc.m300569200	X
ajbspi-134509	257	7	https://doi.org/10.1016/j.mam.2012.05.007	https://doi.org/10.1016/j.mam.2012.05.007	AUX
ajbspi-134509	257	8	https://doi.org/10.1016/j.mam.2012.05.007	https://doi.org/10.1016/j.mam.2012.05.007	VERB
ajbspi-134509	257	9	https://doi.org/10.1016/j.pharmthera.2019.01.003	https://doi.org/10.1016/j.pharmthera.2019.01.003	X
ajbspi-134509	257	10	https://doi.org/10.1016/j.pharmthera.2019.01.003	https://doi.org/10.1016/j.pharmthera.2019.01.003	PROPN
ajbspi-134509	257	11	https://doi.org/10.1177/2398212818817494	https://doi.org/10.1177/2398212818817494	NUM
ajbspi-134509	257	12	https://doi.org/10.1177/2398212818817494	https://doi.org/10.1177/2398212818817494	NUM
ajbspi-134509	257	13	https://doi.org/10.1016/j.imlet.2018.04.006	https://doi.org/10.1016/j.imlet.2018.04.006	ADJ
ajbspi-134509	257	14	https://doi.org/10.1016/j.imlet.2018.04.006	https://doi.org/10.1016/j.imlet.2018.04.006	ADJ
ajbspi-134509	257	15	https://doi.org/10.1111/j.1479-8425.2010.00460.x	https://doi.org/10.1111/j.1479-8425.2010.00460.x	NOUN
ajbspi-134509	257	16	https://doi.org/10.1111/j.1479-8425.2010.00460.x	https://doi.org/10.1111/j.1479-8425.2010.00460.x	NOUN