id	sid	tid	token	lemma	pos
ajird-1356	1	1	american	american	PROPN
ajird-1356	1	2	journal	journal	PROPN
ajird-1356	1	3	of	of	ADP
ajird-1356	1	4	interdisciplinary	interdisciplinary	ADJ
ajird-1356	1	5	research	research	NOUN
ajird-1356	1	6	and	and	CCONJ
ajird-1356	1	7	development	development	NOUN
ajird-1356	1	8	issn	issn	PROPN
ajird-1356	1	9	online	online	NOUN
ajird-1356	1	10	:	:	PUNCT
ajird-1356	1	11	2771	2771	NUM
ajird-1356	1	12	-	-	SYM
ajird-1356	1	13	8948	8948	NUM
ajird-1356	1	14	website	website	NOUN
ajird-1356	1	15	:	:	PUNCT
ajird-1356	1	16	www.ajird.journalspark.org	www.ajird.journalspark.org	ADJ
ajird-1356	1	17	volume	volume	NOUN
ajird-1356	1	18	34	34	NUM
ajird-1356	1	19	,	,	PUNCT
ajird-1356	1	20	november	november	PROPN
ajird-1356	1	21	2024	2024	NUM
ajird-1356	1	22	31	31	NUM
ajird-1356	2	1	|	|	ADV
ajird-1356	2	2	p	p	X
ajird-1356	2	3	a	a	DET
ajird-1356	2	4	g	g	NOUN
ajird-1356	2	5	e	e	NOUN
ajird-1356	2	6	reactive	reactive	ADJ
ajird-1356	2	7	arthritis	arthritis	NOUN
ajird-1356	2	8	:	:	PUNCT
ajird-1356	2	9	literature	literature	PROPN
ajird-1356	2	10	review	review	PROPN
ajird-1356	2	11	,	,	PUNCT
ajird-1356	2	12	target	target	NOUN
ajird-1356	2	13	treatments	treatment	NOUN
ajird-1356	2	14	in	in	ADP
ajird-1356	2	15	the	the	DET
ajird-1356	2	16	era	era	NOUN
ajird-1356	2	17	of	of	ADP
ajird-1356	2	18	biologics	biologic	NOUN
ajird-1356	2	19	javohir	javohir	PROPN
ajird-1356	2	20	mullokulov	mullokulov	PROPN
ajird-1356	2	21	1	1	NUM
ajird-1356	2	22	khalmurad	khalmurad	PROPN
ajird-1356	2	23	sadullayevich	sadullayevich	PROPN
ajird-1356	2	24	akhmedov	akhmedov	PROPN
ajird-1356	2	25	2	2	NUM
ajird-1356	2	26	feruza	feruza	NOUN
ajird-1356	2	27	iskandarovna	iskandarovna	VERB
ajird-1356	2	28	khalmetova	khalmetova	X
ajird-1356	2	29	3	3	NUM
ajird-1356	2	30	,	,	PUNCT
ajird-1356	2	31	1	1	NUM
ajird-1356	2	32	md	md	PROPN
ajird-1356	2	33	,	,	PUNCT
ajird-1356	2	34	tashkent	tashkent	PROPN
ajird-1356	2	35	medical	medical	PROPN
ajird-1356	2	36	academy	academy	PROPN
ajird-1356	2	37	,	,	PUNCT
ajird-1356	2	38	tashkent	tashkent	PROPN
ajird-1356	2	39	,	,	PUNCT
ajird-1356	2	40	uzbekistan	uzbekistan	PROPN
ajird-1356	2	41	email	email	NOUN
ajird-1356	2	42	:	:	PUNCT
ajird-1356	2	43	mullokulov33@gmail.com	mullokulov33@gmail.com	PROPN
ajird-1356	2	44	,	,	PUNCT
ajird-1356	2	45	2professor	2professor	NUM
ajird-1356	2	46	,	,	PUNCT
ajird-1356	2	47	doctor	doctor	NOUN
ajird-1356	2	48	of	of	ADP
ajird-1356	2	49	medical	medical	ADJ
ajird-1356	2	50	sciences	sciences	PROPN
ajird-1356	2	51	,	,	PUNCT
ajird-1356	2	52	tashkent	tashkent	PROPN
ajird-1356	2	53	medical	medical	PROPN
ajird-1356	2	54	academy	academy	PROPN
ajird-1356	2	55	tashkent	tashkent	PROPN
ajird-1356	2	56	,	,	PUNCT
ajird-1356	2	57	uzbekistan	uzbekistan	PROPN
ajird-1356	2	58	e	e	PROPN
ajird-1356	2	59	-	-	NOUN
ajird-1356	2	60	mail	mail	NOUN
ajird-1356	2	61	:	:	PUNCT
ajird-1356	3	1	khalmurad1968@mail.ru	khalmurad1968@mail.ru	VERB
ajird-1356	3	2	,	,	PUNCT
ajird-1356	3	3	3	3	NUM
ajird-1356	3	4	dsc	dsc	NOUN
ajird-1356	3	5	,	,	PUNCT
ajird-1356	3	6	tashkent	tashkent	PROPN
ajird-1356	3	7	medical	medical	PROPN
ajird-1356	3	8	academy	academy	PROPN
ajird-1356	3	9	,	,	PUNCT
ajird-1356	3	10	tashkent	tashkent	PROPN
ajird-1356	3	11	,	,	PUNCT
ajird-1356	3	12	uzbekistan	uzbekistan	PROPN
ajird-1356	3	13	email	email	NOUN
ajird-1356	3	14	:	:	PUNCT
ajird-1356	4	1	f.xalmetova@tma.uz	f.xalmetova@tma.uz	ADJ
ajird-1356	4	2	,	,	PUNCT
ajird-1356	4	3	abstract	abstract	ADJ
ajird-1356	4	4	:	:	PUNCT
ajird-1356	4	5	reactive	reactive	ADJ
ajird-1356	4	6	arthritis	arthritis	NOUN
ajird-1356	4	7	(	(	PUNCT
ajird-1356	4	8	rea	rea	PROPN
ajird-1356	4	9	)	)	PUNCT
ajird-1356	4	10	is	be	AUX
ajird-1356	4	11	an	an	DET
ajird-1356	4	12	autoimmune	autoimmune	ADJ
ajird-1356	4	13	condition	condition	NOUN
ajird-1356	4	14	characterized	characterize	VERB
ajird-1356	4	15	by	by	ADP
ajird-1356	4	16	joint	joint	ADJ
ajird-1356	4	17	inflammation	inflammation	NOUN
ajird-1356	4	18	that	that	SCONJ
ajird-1356	4	19	typically	typically	ADV
ajird-1356	4	20	arises	arise	VERB
ajird-1356	4	21	following	follow	VERB
ajird-1356	4	22	an	an	DET
ajird-1356	4	23	infection	infection	NOUN
ajird-1356	4	24	,	,	PUNCT
ajird-1356	4	25	most	most	ADV
ajird-1356	4	26	commonly	commonly	ADV
ajird-1356	4	27	in	in	ADP
ajird-1356	4	28	the	the	DET
ajird-1356	4	29	gastrointestinal	gastrointestinal	ADJ
ajird-1356	4	30	or	or	CCONJ
ajird-1356	4	31	genitourinary	genitourinary	ADJ
ajird-1356	4	32	tract	tract	NOUN
ajird-1356	4	33	.	.	PUNCT
ajird-1356	5	1	it	it	PRON
ajird-1356	5	2	is	be	AUX
ajird-1356	5	3	considered	consider	VERB
ajird-1356	5	4	part	part	NOUN
ajird-1356	5	5	of	of	ADP
ajird-1356	5	6	the	the	DET
ajird-1356	5	7	broader	broad	ADJ
ajird-1356	5	8	spectrum	spectrum	NOUN
ajird-1356	5	9	of	of	ADP
ajird-1356	5	10	spondyloarthropathies	spondyloarthropathie	NOUN
ajird-1356	5	11	,	,	PUNCT
ajird-1356	5	12	with	with	ADP
ajird-1356	5	13	hallmark	hallmark	ADJ
ajird-1356	5	14	symptoms	symptom	NOUN
ajird-1356	5	15	including	include	VERB
ajird-1356	5	16	asymmetric	asymmetric	ADJ
ajird-1356	5	17	arthritis	arthritis	NOUN
ajird-1356	5	18	,	,	PUNCT
ajird-1356	5	19	enthesitis	enthesitis	NOUN
ajird-1356	5	20	,	,	PUNCT
ajird-1356	5	21	and	and	CCONJ
ajird-1356	5	22	dactylitis	dactylitis	NOUN
ajird-1356	5	23	,	,	PUNCT
ajird-1356	5	24	often	often	ADV
ajird-1356	5	25	involving	involve	VERB
ajird-1356	5	26	the	the	DET
ajird-1356	5	27	lower	low	ADJ
ajird-1356	5	28	limbs	limb	NOUN
ajird-1356	5	29	.	.	PUNCT
ajird-1356	6	1	the	the	DET
ajird-1356	6	2	condition	condition	NOUN
ajird-1356	6	3	is	be	AUX
ajird-1356	6	4	triggered	trigger	VERB
ajird-1356	6	5	by	by	ADP
ajird-1356	6	6	bacterial	bacterial	ADJ
ajird-1356	6	7	infections	infection	NOUN
ajird-1356	6	8	,	,	PUNCT
ajird-1356	6	9	such	such	ADJ
ajird-1356	6	10	as	as	ADP
ajird-1356	6	11	chlamydia	chlamydia	NOUN
ajird-1356	6	12	trachomatis	trachomatis	ADJ
ajird-1356	6	13	,	,	PUNCT
ajird-1356	6	14	salmonella	salmonella	NOUN
ajird-1356	6	15	,	,	PUNCT
ajird-1356	6	16	or	or	CCONJ
ajird-1356	6	17	campylobacter	campylobacter	NOUN
ajird-1356	6	18	,	,	PUNCT
ajird-1356	6	19	although	although	SCONJ
ajird-1356	6	20	the	the	DET
ajird-1356	6	21	exact	exact	ADJ
ajird-1356	6	22	pathogenic	pathogenic	ADJ
ajird-1356	6	23	mechanisms	mechanism	NOUN
ajird-1356	6	24	remain	remain	VERB
ajird-1356	6	25	unclear	unclear	ADJ
ajird-1356	6	26	.	.	PUNCT
ajird-1356	7	1	reactive	reactive	ADJ
ajird-1356	7	2	arthritis	arthritis	NOUN
ajird-1356	7	3	may	may	AUX
ajird-1356	7	4	manifest	manifest	VERB
ajird-1356	7	5	as	as	ADP
ajird-1356	7	6	acute	acute	NOUN
ajird-1356	7	7	,	,	PUNCT
ajird-1356	7	8	self	self	NOUN
ajird-1356	7	9	-	-	PUNCT
ajird-1356	7	10	limiting	limit	VERB
ajird-1356	7	11	inflammation	inflammation	NOUN
ajird-1356	7	12	,	,	PUNCT
ajird-1356	7	13	or	or	CCONJ
ajird-1356	7	14	progress	progress	NOUN
ajird-1356	7	15	to	to	ADP
ajird-1356	7	16	a	a	DET
ajird-1356	7	17	chronic	chronic	ADJ
ajird-1356	7	18	condition	condition	NOUN
ajird-1356	7	19	,	,	PUNCT
ajird-1356	7	20	leading	lead	VERB
ajird-1356	7	21	to	to	ADP
ajird-1356	7	22	prolonged	prolong	VERB
ajird-1356	7	23	disability	disability	NOUN
ajird-1356	7	24	and	and	CCONJ
ajird-1356	7	25	joint	joint	ADJ
ajird-1356	7	26	damage	damage	NOUN
ajird-1356	7	27	in	in	ADP
ajird-1356	7	28	severe	severe	ADJ
ajird-1356	7	29	cases.[1	cases.[1	NOUN
ajird-1356	7	30	]	]	PUNCT
ajird-1356	7	31	.	.	PUNCT
ajird-1356	8	1	this	this	DET
ajird-1356	8	2	review	review	NOUN
ajird-1356	8	3	explores	explore	VERB
ajird-1356	8	4	the	the	DET
ajird-1356	8	5	clinical	clinical	ADJ
ajird-1356	8	6	presentation	presentation	NOUN
ajird-1356	8	7	,	,	PUNCT
ajird-1356	8	8	pathophysiology	pathophysiology	NOUN
ajird-1356	8	9	,	,	PUNCT
ajird-1356	8	10	diagnostic	diagnostic	ADJ
ajird-1356	8	11	criteria	criterion	NOUN
ajird-1356	8	12	,	,	PUNCT
ajird-1356	8	13	and	and	CCONJ
ajird-1356	8	14	treatment	treatment	NOUN
ajird-1356	8	15	strategies	strategy	NOUN
ajird-1356	8	16	for	for	ADP
ajird-1356	8	17	rea	rea	PROPN
ajird-1356	8	18	.	.	PUNCT
ajird-1356	9	1	therapeutic	therapeutic	ADJ
ajird-1356	9	2	interventions	intervention	NOUN
ajird-1356	9	3	range	range	VERB
ajird-1356	9	4	from	from	ADP
ajird-1356	9	5	nonsteroidal	nonsteroidal	ADJ
ajird-1356	9	6	anti	anti	ADJ
ajird-1356	9	7	-	-	ADJ
ajird-1356	9	8	inflammatory	inflammatory	ADJ
ajird-1356	9	9	drugs	drug	NOUN
ajird-1356	9	10	(	(	PUNCT
ajird-1356	9	11	nsaids	nsaid	NOUN
ajird-1356	9	12	)	)	PUNCT
ajird-1356	9	13	for	for	ADP
ajird-1356	9	14	pain	pain	NOUN
ajird-1356	9	15	management	management	NOUN
ajird-1356	9	16	to	to	AUX
ajird-1356	9	17	disease	disease	NOUN
ajird-1356	9	18	-	-	PUNCT
ajird-1356	9	19	modifying	modify	VERB
ajird-1356	9	20	antirheumatic	antirheumatic	ADJ
ajird-1356	9	21	drugs	drug	NOUN
ajird-1356	9	22	(	(	PUNCT
ajird-1356	9	23	dmards	dmard	NOUN
ajird-1356	9	24	)	)	PUNCT
ajird-1356	9	25	and	and	CCONJ
ajird-1356	9	26	biologic	biologic	NOUN
ajird-1356	9	27	agents	agent	NOUN
ajird-1356	9	28	like	like	ADP
ajird-1356	9	29	tnf	tnf	PROPN
ajird-1356	9	30	inhibitors	inhibitor	NOUN
ajird-1356	9	31	for	for	ADP
ajird-1356	9	32	persistent	persistent	ADJ
ajird-1356	9	33	and	and	CCONJ
ajird-1356	9	34	severe	severe	ADJ
ajird-1356	9	35	cases	case	NOUN
ajird-1356	9	36	.	.	PUNCT
ajird-1356	10	1	recent	recent	ADJ
ajird-1356	10	2	advances	advance	NOUN
ajird-1356	10	3	in	in	ADP
ajird-1356	10	4	understanding	understand	VERB
ajird-1356	10	5	the	the	DET
ajird-1356	10	6	molecular	molecular	ADJ
ajird-1356	10	7	mechanisms	mechanism	NOUN
ajird-1356	10	8	,	,	PUNCT
ajird-1356	10	9	particularly	particularly	ADV
ajird-1356	10	10	the	the	DET
ajird-1356	10	11	role	role	NOUN
ajird-1356	10	12	of	of	ADP
ajird-1356	10	13	hla	hla	PROPN
ajird-1356	10	14	-	-	PUNCT
ajird-1356	10	15	b27	b27	NOUN
ajird-1356	10	16	and	and	CCONJ
ajird-1356	10	17	cytokine	cytokine	ADJ
ajird-1356	10	18	dysregulation	dysregulation	NOUN
ajird-1356	10	19	,	,	PUNCT
ajird-1356	10	20	offer	offer	VERB
ajird-1356	10	21	new	new	ADJ
ajird-1356	10	22	insights	insight	NOUN
ajird-1356	10	23	into	into	ADP
ajird-1356	10	24	potential	potential	ADJ
ajird-1356	10	25	therapeutic	therapeutic	ADJ
ajird-1356	10	26	targets	target	NOUN
ajird-1356	10	27	.	.	PUNCT
ajird-1356	11	1	early	early	ADJ
ajird-1356	11	2	diagnosis	diagnosis	NOUN
ajird-1356	11	3	and	and	CCONJ
ajird-1356	11	4	appropriate	appropriate	ADJ
ajird-1356	11	5	management	management	NOUN
ajird-1356	11	6	are	be	AUX
ajird-1356	11	7	crucial	crucial	ADJ
ajird-1356	11	8	for	for	ADP
ajird-1356	11	9	preventing	prevent	VERB
ajird-1356	11	10	long	long	ADJ
ajird-1356	11	11	-	-	PUNCT
ajird-1356	11	12	term	term	NOUN
ajird-1356	11	13	complications	complication	NOUN
ajird-1356	11	14	and	and	CCONJ
ajird-1356	11	15	improving	improve	VERB
ajird-1356	11	16	patient	patient	ADJ
ajird-1356	11	17	outcomes	outcome	NOUN
ajird-1356	11	18	.	.	PUNCT
ajird-1356	12	1	this	this	DET
ajird-1356	12	2	article	article	NOUN
ajird-1356	12	3	also	also	ADV
ajird-1356	12	4	discusses	discuss	VERB
ajird-1356	12	5	emerging	emerge	VERB
ajird-1356	12	6	treatments	treatment	NOUN
ajird-1356	12	7	and	and	CCONJ
ajird-1356	12	8	the	the	DET
ajird-1356	12	9	challenges	challenge	NOUN
ajird-1356	12	10	of	of	ADP
ajird-1356	12	11	managing	manage	VERB
ajird-1356	12	12	rea	rea	NOUN
ajird-1356	12	13	in	in	ADP
ajird-1356	12	14	the	the	DET
ajird-1356	12	15	context	context	NOUN
ajird-1356	12	16	of	of	ADP
ajird-1356	12	17	coexisting	coexist	VERB
ajird-1356	12	18	infections	infection	NOUN
ajird-1356	12	19	and	and	CCONJ
ajird-1356	12	20	chronic	chronic	ADJ
ajird-1356	12	21	disease.[2	disease.[2	NOUN
ajird-1356	12	22	]	]	PUNCT
ajird-1356	12	23	.	.	PUNCT
ajird-1356	13	1	keywords	keyword	NOUN
ajird-1356	13	2	:	:	PUNCT
ajird-1356	13	3	hla	hla	NOUN
ajird-1356	13	4	-	-	PUNCT
ajird-1356	13	5	b27	b27	PROPN
ajird-1356	13	6	,	,	PUNCT
ajird-1356	13	7	reactive	reactive	ADJ
ajird-1356	13	8	arthritis	arthritis	NOUN
ajird-1356	13	9	,	,	PUNCT
ajird-1356	13	10	tnf	tnf	PROPN
ajird-1356	13	11	inhibitors	inhibitor	NOUN
ajird-1356	13	12	,	,	PUNCT
ajird-1356	13	13	jak	jak	PROPN
ajird-1356	13	14	inhibitors	inhibitor	NOUN
ajird-1356	13	15	.	.	PUNCT
ajird-1356	14	1	american	american	ADJ
ajird-1356	14	2	journal	journal	PROPN
ajird-1356	14	3	of	of	ADP
ajird-1356	14	4	interdisciplinary	interdisciplinary	ADJ
ajird-1356	14	5	research	research	NOUN
ajird-1356	14	6	and	and	CCONJ
ajird-1356	14	7	development	development	NOUN
ajird-1356	14	8	issn	issn	PROPN
ajird-1356	14	9	online	online	NOUN
ajird-1356	14	10	:	:	PUNCT
ajird-1356	14	11	2771	2771	NUM
ajird-1356	14	12	-	-	SYM
ajird-1356	14	13	8948	8948	NUM
ajird-1356	14	14	website	website	NOUN
ajird-1356	14	15	:	:	PUNCT
ajird-1356	14	16	www.ajird.journalspark.org	www.ajird.journalspark.org	ADJ
ajird-1356	14	17	volume	volume	NOUN
ajird-1356	14	18	34	34	NUM
ajird-1356	14	19	,	,	PUNCT
ajird-1356	14	20	november	november	PROPN
ajird-1356	14	21	2024	2024	NUM
ajird-1356	14	22	32	32	NUM
ajird-1356	15	1	|	|	ADV
ajird-1356	15	2	p	p	X
ajird-1356	15	3	a	a	DET
ajird-1356	15	4	g	g	NOUN
ajird-1356	15	5	e	e	NOUN
ajird-1356	15	6	introduction	introduction	NOUN
ajird-1356	15	7	reactive	reactive	ADJ
ajird-1356	15	8	arthritis	arthritis	NOUN
ajird-1356	15	9	(	(	PUNCT
ajird-1356	15	10	rea	rea	PROPN
ajird-1356	15	11	)	)	PUNCT
ajird-1356	15	12	is	be	AUX
ajird-1356	15	13	an	an	DET
ajird-1356	15	14	inflammatory	inflammatory	ADJ
ajird-1356	15	15	condition	condition	NOUN
ajird-1356	15	16	that	that	PRON
ajird-1356	15	17	occurs	occur	VERB
ajird-1356	15	18	following	follow	VERB
ajird-1356	15	19	an	an	DET
ajird-1356	15	20	infection	infection	NOUN
ajird-1356	15	21	,	,	PUNCT
ajird-1356	15	22	typically	typically	ADV
ajird-1356	15	23	in	in	ADP
ajird-1356	15	24	the	the	DET
ajird-1356	15	25	gastrointestinal	gastrointestinal	ADJ
ajird-1356	15	26	or	or	CCONJ
ajird-1356	15	27	genitourinary	genitourinary	ADJ
ajird-1356	15	28	tract	tract	NOUN
ajird-1356	15	29	.	.	PUNCT
ajird-1356	16	1	although	although	SCONJ
ajird-1356	16	2	the	the	DET
ajird-1356	16	3	initial	initial	ADJ
ajird-1356	16	4	infection	infection	NOUN
ajird-1356	16	5	is	be	AUX
ajird-1356	16	6	typically	typically	ADV
ajird-1356	16	7	resolved	resolve	VERB
ajird-1356	16	8	by	by	ADP
ajird-1356	16	9	the	the	DET
ajird-1356	16	10	time	time	NOUN
ajird-1356	16	11	arthritis	arthritis	NOUN
ajird-1356	16	12	develops	develop	VERB
ajird-1356	16	13	,	,	PUNCT
ajird-1356	16	14	a	a	DET
ajird-1356	16	15	maladaptive	maladaptive	ADJ
ajird-1356	16	16	immune	immune	ADJ
ajird-1356	16	17	response	response	NOUN
ajird-1356	16	18	continues	continue	VERB
ajird-1356	16	19	,	,	PUNCT
ajird-1356	16	20	triggering	trigger	VERB
ajird-1356	16	21	inflammation	inflammation	NOUN
ajird-1356	16	22	primarily	primarily	ADV
ajird-1356	16	23	in	in	ADP
ajird-1356	16	24	the	the	DET
ajird-1356	16	25	joints	joint	NOUN
ajird-1356	16	26	.	.	PUNCT
ajird-1356	17	1	rea	rea	PROPN
ajird-1356	17	2	is	be	AUX
ajird-1356	17	3	classified	classify	VERB
ajird-1356	17	4	under	under	ADP
ajird-1356	17	5	the	the	DET
ajird-1356	17	6	group	group	NOUN
ajird-1356	17	7	of	of	ADP
ajird-1356	17	8	spondyloarthritides	spondyloarthritides	PROPN
ajird-1356	17	9	(	(	PUNCT
ajird-1356	17	10	spa	spa	NOUN
ajird-1356	17	11	)	)	PUNCT
ajird-1356	17	12	,	,	PUNCT
ajird-1356	17	13	a	a	DET
ajird-1356	17	14	family	family	NOUN
ajird-1356	17	15	of	of	ADP
ajird-1356	17	16	disorders	disorder	NOUN
ajird-1356	17	17	characterized	characterize	VERB
ajird-1356	17	18	by	by	ADP
ajird-1356	17	19	inflammation	inflammation	NOUN
ajird-1356	17	20	of	of	ADP
ajird-1356	17	21	the	the	DET
ajird-1356	17	22	spine	spine	ADJ
ajird-1356	17	23	and	and	CCONJ
ajird-1356	17	24	peripheral	peripheral	ADJ
ajird-1356	17	25	joints	joint	NOUN
ajird-1356	17	26	,	,	PUNCT
ajird-1356	17	27	and	and	CCONJ
ajird-1356	17	28	is	be	AUX
ajird-1356	17	29	closely	closely	ADV
ajird-1356	17	30	linked	link	VERB
ajird-1356	17	31	to	to	ADP
ajird-1356	17	32	the	the	DET
ajird-1356	17	33	genetic	genetic	ADJ
ajird-1356	17	34	marker	marker	NOUN
ajird-1356	17	35	hla	hla	PROPN
ajird-1356	17	36	-	-	PUNCT
ajird-1356	17	37	b27	b27	PROPN
ajird-1356	17	38	.	.	PUNCT
ajird-1356	18	1	the	the	DET
ajird-1356	18	2	pathogenesis	pathogenesis	NOUN
ajird-1356	18	3	of	of	ADP
ajird-1356	18	4	rea	rea	PROPN
ajird-1356	18	5	is	be	AUX
ajird-1356	18	6	complex	complex	ADJ
ajird-1356	18	7	and	and	CCONJ
ajird-1356	18	8	involves	involve	VERB
ajird-1356	18	9	a	a	DET
ajird-1356	18	10	combination	combination	NOUN
ajird-1356	18	11	of	of	ADP
ajird-1356	18	12	genetic	genetic	ADJ
ajird-1356	18	13	predisposition	predisposition	NOUN
ajird-1356	18	14	,	,	PUNCT
ajird-1356	18	15	microbial	microbial	ADJ
ajird-1356	18	16	infection	infection	NOUN
ajird-1356	18	17	,	,	PUNCT
ajird-1356	18	18	and	and	CCONJ
ajird-1356	18	19	immune	immune	ADJ
ajird-1356	18	20	dysregulation	dysregulation	NOUN
ajird-1356	18	21	.	.	PUNCT
ajird-1356	19	1	in	in	ADP
ajird-1356	19	2	this	this	DET
ajird-1356	19	3	section	section	NOUN
ajird-1356	19	4	,	,	PUNCT
ajird-1356	19	5	we	we	PRON
ajird-1356	19	6	will	will	AUX
ajird-1356	19	7	explore	explore	VERB
ajird-1356	19	8	the	the	DET
ajird-1356	19	9	intricate	intricate	ADJ
ajird-1356	19	10	immunological	immunological	ADJ
ajird-1356	19	11	processes	process	NOUN
ajird-1356	19	12	and	and	CCONJ
ajird-1356	19	13	factors	factor	NOUN
ajird-1356	19	14	that	that	PRON
ajird-1356	19	15	contribute	contribute	VERB
ajird-1356	19	16	to	to	ADP
ajird-1356	19	17	the	the	DET
ajird-1356	19	18	development	development	NOUN
ajird-1356	19	19	and	and	CCONJ
ajird-1356	19	20	progression	progression	NOUN
ajird-1356	19	21	of	of	ADP
ajird-1356	19	22	rea	rea	PROPN
ajird-1356	19	23	.	.	PUNCT
ajird-1356	20	1	genetic	genetic	ADJ
ajird-1356	20	2	predisposition	predisposition	NOUN
ajird-1356	20	3	:	:	PUNCT
ajird-1356	20	4	a	a	DET
ajird-1356	20	5	critical	critical	ADJ
ajird-1356	20	6	component	component	NOUN
ajird-1356	20	7	of	of	ADP
ajird-1356	20	8	rea	rea	PROPN
ajird-1356	20	9	pathogenesis	pathogenesis	PROPN
ajird-1356	20	10	is	be	AUX
ajird-1356	20	11	the	the	DET
ajird-1356	20	12	strong	strong	ADJ
ajird-1356	20	13	association	association	NOUN
ajird-1356	20	14	with	with	ADP
ajird-1356	20	15	the	the	DET
ajird-1356	20	16	hla	hla	PROPN
ajird-1356	20	17	-	-	PUNCT
ajird-1356	20	18	b27	b27	NOUN
ajird-1356	20	19	gene	gene	NOUN
ajird-1356	20	20	,	,	PUNCT
ajird-1356	20	21	a	a	DET
ajird-1356	20	22	class	class	NOUN
ajird-1356	20	23	i	i	PRON
ajird-1356	20	24	major	major	ADJ
ajird-1356	20	25	histocompatibility	histocompatibility	NOUN
ajird-1356	20	26	complex	complex	NOUN
ajird-1356	20	27	(	(	PUNCT
ajird-1356	20	28	mhc	mhc	NOUN
ajird-1356	20	29	)	)	PUNCT
ajird-1356	20	30	molecule	molecule	NOUN
ajird-1356	20	31	.	.	PUNCT
ajird-1356	21	1	hla	hla	PROPN
ajird-1356	21	2	-	-	PUNCT
ajird-1356	21	3	b27	b27	PROPN
ajird-1356	21	4	is	be	AUX
ajird-1356	21	5	present	present	ADJ
ajird-1356	21	6	in	in	ADP
ajird-1356	21	7	approximately	approximately	ADV
ajird-1356	21	8	6080	6080	NUM
ajird-1356	21	9	%	%	NOUN
ajird-1356	21	10	of	of	ADP
ajird-1356	21	11	patients	patient	NOUN
ajird-1356	21	12	with	with	ADP
ajird-1356	21	13	rea	rea	PROPN
ajird-1356	21	14	,	,	PUNCT
ajird-1356	21	15	compared	compare	VERB
ajird-1356	21	16	to	to	ADP
ajird-1356	21	17	6	6	NUM
ajird-1356	21	18	-	-	SYM
ajird-1356	21	19	8	8	NUM
ajird-1356	21	20	%	%	NOUN
ajird-1356	21	21	in	in	ADP
ajird-1356	21	22	the	the	DET
ajird-1356	21	23	general	general	ADJ
ajird-1356	21	24	population	population	NOUN
ajird-1356	21	25	.	.	PUNCT
ajird-1356	22	1	however	however	ADV
ajird-1356	22	2	,	,	PUNCT
ajird-1356	22	3	not	not	PART
ajird-1356	22	4	all	all	DET
ajird-1356	22	5	individuals	individual	NOUN
ajird-1356	22	6	carrying	carry	VERB
ajird-1356	22	7	this	this	DET
ajird-1356	22	8	allele	allele	NOUN
ajird-1356	22	9	develop	develop	VERB
ajird-1356	22	10	rea	rea	PROPN
ajird-1356	22	11	,	,	PUNCT
ajird-1356	22	12	indicating	indicate	VERB
ajird-1356	22	13	that	that	SCONJ
ajird-1356	22	14	other	other	ADJ
ajird-1356	22	15	factors	factor	NOUN
ajird-1356	22	16	such	such	ADJ
ajird-1356	22	17	as	as	ADP
ajird-1356	22	18	infection	infection	NOUN
ajird-1356	22	19	and	and	CCONJ
ajird-1356	22	20	immune	immune	ADJ
ajird-1356	22	21	dysregulation	dysregulation	NOUN
ajird-1356	22	22	also	also	ADV
ajird-1356	22	23	play	play	VERB
ajird-1356	22	24	significant	significant	ADJ
ajird-1356	22	25	roles	role	NOUN
ajird-1356	22	26	.	.	PUNCT
ajird-1356	23	1	the	the	DET
ajird-1356	23	2	exact	exact	ADJ
ajird-1356	23	3	mechanism	mechanism	NOUN
ajird-1356	23	4	by	by	ADP
ajird-1356	23	5	which	which	PRON
ajird-1356	23	6	hlab27	hlab27	NOUN
ajird-1356	23	7	contributes	contribute	VERB
ajird-1356	23	8	to	to	ADP
ajird-1356	23	9	disease	disease	NOUN
ajird-1356	23	10	susceptibility	susceptibility	NOUN
ajird-1356	23	11	is	be	AUX
ajird-1356	23	12	still	still	ADV
ajird-1356	23	13	debated	debate	VERB
ajird-1356	23	14	.	.	PUNCT
ajird-1356	24	1	several	several	ADJ
ajird-1356	24	2	hypotheses	hypothesis	NOUN
ajird-1356	24	3	have	have	AUX
ajird-1356	24	4	been	be	AUX
ajird-1356	24	5	proposed	propose	VERB
ajird-1356	24	6	:	:	PUNCT
ajird-1356	24	7	1)misfolding	1)misfolding	NUM
ajird-1356	24	8	hypothesis	hypothesis	NOUN
ajird-1356	24	9	:	:	PUNCT
ajird-1356	24	10	hla	hla	PROPN
ajird-1356	24	11	-	-	PUNCT
ajird-1356	24	12	b27	b27	PROPN
ajird-1356	24	13	has	have	VERB
ajird-1356	24	14	a	a	DET
ajird-1356	24	15	tendency	tendency	NOUN
ajird-1356	24	16	to	to	PART
ajird-1356	24	17	misfold	misfold	VERB
ajird-1356	24	18	,	,	PUNCT
ajird-1356	24	19	leading	lead	VERB
ajird-1356	24	20	to	to	ADP
ajird-1356	24	21	endoplasmic	endoplasmic	ADJ
ajird-1356	24	22	reticulum	reticulum	NOUN
ajird-1356	24	23	(	(	PUNCT
ajird-1356	24	24	er	er	INTJ
ajird-1356	24	25	)	)	PUNCT
ajird-1356	24	26	stress	stress	NOUN
ajird-1356	24	27	.	.	PUNCT
ajird-1356	25	1	this	this	PRON
ajird-1356	25	2	can	can	AUX
ajird-1356	25	3	activate	activate	VERB
ajird-1356	25	4	the	the	DET
ajird-1356	25	5	unfolded	unfolded	ADJ
ajird-1356	25	6	protein	protein	NOUN
ajird-1356	25	7	response	response	NOUN
ajird-1356	25	8	(	(	PUNCT
ajird-1356	25	9	upr	upr	NOUN
ajird-1356	25	10	)	)	PUNCT
ajird-1356	25	11	,	,	PUNCT
ajird-1356	25	12	leading	lead	VERB
ajird-1356	25	13	to	to	ADP
ajird-1356	25	14	inflammation	inflammation	NOUN
ajird-1356	25	15	.	.	PUNCT
ajird-1356	26	1	2)molecular	2)molecular	NUM
ajird-1356	26	2	mimicry	mimicry	ADJ
ajird-1356	26	3	:	:	PUNCT
ajird-1356	26	4	hla	hla	NOUN
ajird-1356	26	5	-	-	PUNCT
ajird-1356	26	6	b27	b27	PROPN
ajird-1356	26	7	might	might	AUX
ajird-1356	26	8	present	present	VERB
ajird-1356	26	9	bacterial	bacterial	ADJ
ajird-1356	26	10	peptides	peptide	NOUN
ajird-1356	26	11	that	that	PRON
ajird-1356	26	12	resemble	resemble	VERB
ajird-1356	26	13	self	self	NOUN
ajird-1356	26	14	-	-	PUNCT
ajird-1356	26	15	antigens	antigen	NOUN
ajird-1356	26	16	,	,	PUNCT
ajird-1356	26	17	leading	lead	VERB
ajird-1356	26	18	to	to	ADP
ajird-1356	26	19	an	an	DET
ajird-1356	26	20	autoimmune	autoimmune	ADJ
ajird-1356	26	21	response	response	NOUN
ajird-1356	26	22	where	where	SCONJ
ajird-1356	26	23	the	the	DET
ajird-1356	26	24	immune	immune	ADJ
ajird-1356	26	25	system	system	NOUN
ajird-1356	26	26	mistakenly	mistakenly	ADV
ajird-1356	26	27	attacks	attack	VERB
ajird-1356	26	28	healthy	healthy	ADJ
ajird-1356	26	29	joint	joint	ADJ
ajird-1356	26	30	tissues	tissue	NOUN
ajird-1356	26	31	.	.	PUNCT
ajird-1356	27	1	3)abnormal	3)abnormal	NUM
ajird-1356	27	2	antigen	antigen	ADJ
ajird-1356	27	3	presentation	presentation	NOUN
ajird-1356	27	4	:	:	PUNCT
ajird-1356	27	5	hla	hla	NOUN
ajird-1356	27	6	-	-	PUNCT
ajird-1356	27	7	b27	b27	PROPN
ajird-1356	27	8	may	may	AUX
ajird-1356	27	9	present	present	VERB
ajird-1356	27	10	certain	certain	ADJ
ajird-1356	27	11	bacterial	bacterial	ADJ
ajird-1356	27	12	antigens	antigen	NOUN
ajird-1356	27	13	in	in	ADP
ajird-1356	27	14	an	an	DET
ajird-1356	27	15	abnormal	abnormal	ADJ
ajird-1356	27	16	way	way	NOUN
ajird-1356	27	17	,	,	PUNCT
ajird-1356	27	18	provoking	provoke	VERB
ajird-1356	27	19	a	a	DET
ajird-1356	27	20	heightened	heightened	ADJ
ajird-1356	27	21	immune	immune	ADJ
ajird-1356	27	22	response	response	NOUN
ajird-1356	27	23	.	.	PUNCT
ajird-1356	28	1	microbial	microbial	ADJ
ajird-1356	28	2	triggers	trigger	NOUN
ajird-1356	28	3	:	:	PUNCT
ajird-1356	28	4	the	the	DET
ajird-1356	28	5	development	development	NOUN
ajird-1356	28	6	of	of	ADP
ajird-1356	28	7	reactive	reactive	ADJ
ajird-1356	28	8	arthritis	arthritis	NOUN
ajird-1356	28	9	is	be	AUX
ajird-1356	28	10	typically	typically	ADV
ajird-1356	28	11	preceded	precede	VERB
ajird-1356	28	12	by	by	ADP
ajird-1356	28	13	infections	infection	NOUN
ajird-1356	28	14	with	with	ADP
ajird-1356	28	15	certain	certain	ADJ
ajird-1356	28	16	gram	gram	NOUN
ajird-1356	28	17	-	-	PUNCT
ajird-1356	28	18	negative	negative	ADJ
ajird-1356	28	19	bacteria	bacteria	NOUN
ajird-1356	28	20	.	.	PUNCT
ajird-1356	29	1	common	common	ADJ
ajird-1356	29	2	causative	causative	ADJ
ajird-1356	29	3	organisms	organism	NOUN
ajird-1356	29	4	include	include	VERB
ajird-1356	29	5	:	:	PUNCT
ajird-1356	29	6	chlamydia	chlamydia	NOUN
ajird-1356	29	7	trachomatis	trachomatis	ADJ
ajird-1356	29	8	(	(	PUNCT
ajird-1356	29	9	genitourinary	genitourinary	ADJ
ajird-1356	29	10	infections	infection	NOUN
ajird-1356	29	11	)	)	PUNCT
ajird-1356	29	12	,	,	PUNCT
ajird-1356	29	13	salmonella	salmonella	NOUN
ajird-1356	29	14	,	,	PUNCT
ajird-1356	29	15	shigella	shigella	PROPN
ajird-1356	29	16	,	,	PUNCT
ajird-1356	29	17	yersinia	yersinia	NOUN
ajird-1356	29	18	,	,	PUNCT
ajird-1356	29	19	and	and	CCONJ
ajird-1356	29	20	campylobacter	campylobacter	NOUN
ajird-1356	29	21	(	(	PUNCT
ajird-1356	29	22	gastrointestinal	gastrointestinal	ADJ
ajird-1356	29	23	infections	infection	NOUN
ajird-1356	29	24	)	)	PUNCT
ajird-1356	29	25	.	.	PUNCT
ajird-1356	30	1	although	although	SCONJ
ajird-1356	30	2	the	the	DET
ajird-1356	30	3	infection	infection	NOUN
ajird-1356	30	4	is	be	AUX
ajird-1356	30	5	resolved	resolve	VERB
ajird-1356	30	6	,	,	PUNCT
ajird-1356	30	7	components	component	NOUN
ajird-1356	30	8	of	of	ADP
ajird-1356	30	9	the	the	DET
ajird-1356	30	10	bacterial	bacterial	ADJ
ajird-1356	30	11	pathogen	pathogen	NOUN
ajird-1356	30	12	persist	persist	NOUN
ajird-1356	30	13	in	in	ADP
ajird-1356	30	14	the	the	DET
ajird-1356	30	15	body	body	NOUN
ajird-1356	30	16	and	and	CCONJ
ajird-1356	30	17	act	act	NOUN
ajird-1356	30	18	as	as	ADP
ajird-1356	30	19	chronic	chronic	ADJ
ajird-1356	30	20	triggers	trigger	NOUN
ajird-1356	30	21	for	for	ADP
ajird-1356	30	22	the	the	DET
ajird-1356	30	23	immune	immune	ADJ
ajird-1356	30	24	system	system	NOUN
ajird-1356	30	25	.	.	PUNCT
ajird-1356	31	1	these	these	DET
ajird-1356	31	2	bacterial	bacterial	ADJ
ajird-1356	31	3	antigens	antigen	NOUN
ajird-1356	31	4	are	be	AUX
ajird-1356	31	5	believed	believe	VERB
ajird-1356	31	6	to	to	PART
ajird-1356	31	7	be	be	AUX
ajird-1356	31	8	transported	transport	VERB
ajird-1356	31	9	to	to	ADP
ajird-1356	31	10	the	the	DET
ajird-1356	31	11	synovial	synovial	ADJ
ajird-1356	31	12	fluid	fluid	NOUN
ajird-1356	31	13	via	via	ADP
ajird-1356	31	14	blood	blood	NOUN
ajird-1356	31	15	or	or	CCONJ
ajird-1356	31	16	lymphatics	lymphatic	NOUN
ajird-1356	31	17	.	.	PUNCT
ajird-1356	32	1	there	there	ADV
ajird-1356	32	2	,	,	PUNCT
ajird-1356	32	3	they	they	PRON
ajird-1356	32	4	are	be	AUX
ajird-1356	32	5	recognized	recognize	VERB
ajird-1356	32	6	by	by	ADP
ajird-1356	32	7	the	the	DET
ajird-1356	32	8	immune	immune	ADJ
ajird-1356	32	9	system	system	NOUN
ajird-1356	32	10	,	,	PUNCT
ajird-1356	32	11	stimulating	stimulate	VERB
ajird-1356	32	12	chronic	chronic	ADJ
ajird-1356	32	13	inflammation	inflammation	NOUN
ajird-1356	32	14	.	.	PUNCT
ajird-1356	33	1	some	some	DET
ajird-1356	33	2	bacterial	bacterial	ADJ
ajird-1356	33	3	proteins	protein	NOUN
ajird-1356	33	4	mimic	mimic	VERB
ajird-1356	33	5	human	human	ADJ
ajird-1356	33	6	proteins	protein	NOUN
ajird-1356	33	7	,	,	PUNCT
ajird-1356	33	8	leading	lead	VERB
ajird-1356	33	9	to	to	ADP
ajird-1356	33	10	cross	cross	NOUN
ajird-1356	33	11	-	-	NOUN
ajird-1356	33	12	reactivity	reactivity	NOUN
ajird-1356	33	13	where	where	SCONJ
ajird-1356	33	14	the	the	DET
ajird-1356	33	15	immune	immune	ADJ
ajird-1356	33	16	system	system	NOUN
ajird-1356	33	17	mistakenly	mistakenly	ADV
ajird-1356	33	18	attacks	attack	VERB
ajird-1356	33	19	both	both	CCONJ
ajird-1356	33	20	the	the	DET
ajird-1356	33	21	bacterial	bacterial	ADJ
ajird-1356	33	22	antigen	antigen	NOUN
ajird-1356	33	23	and	and	CCONJ
ajird-1356	33	24	the	the	DET
ajird-1356	33	25	body	body	NOUN
ajird-1356	33	26	’s	’s	PART
ajird-1356	33	27	own	own	ADJ
ajird-1356	33	28	tissues	tissue	NOUN
ajird-1356	33	29	.	.	PUNCT
ajird-1356	34	1	bacterial	bacterial	ADJ
ajird-1356	34	2	antigens	antigen	NOUN
ajird-1356	34	3	or	or	CCONJ
ajird-1356	34	4	remnants	remnant	NOUN
ajird-1356	34	5	can	can	AUX
ajird-1356	34	6	persist	persist	VERB
ajird-1356	34	7	in	in	ADP
ajird-1356	34	8	synovial	synovial	ADJ
ajird-1356	34	9	fluid	fluid	NOUN
ajird-1356	34	10	,	,	PUNCT
ajird-1356	34	11	where	where	SCONJ
ajird-1356	34	12	they	they	PRON
ajird-1356	34	13	stimulate	stimulate	VERB
ajird-1356	34	14	an	an	DET
ajird-1356	34	15	ongoing	ongoing	ADJ
ajird-1356	34	16	immune	immune	ADJ
ajird-1356	34	17	response	response	NOUN
ajird-1356	34	18	despite	despite	SCONJ
ajird-1356	34	19	the	the	DET
ajird-1356	34	20	clearance	clearance	NOUN
ajird-1356	34	21	of	of	ADP
ajird-1356	34	22	the	the	DET
ajird-1356	34	23	primary	primary	ADJ
ajird-1356	34	24	infection	infection	NOUN
ajird-1356	34	25	.	.	PUNCT
ajird-1356	35	1	bacterial	bacterial	ADJ
ajird-1356	35	2	infections	infection	NOUN
ajird-1356	35	3	upregulate	upregulate	VERB
ajird-1356	35	4	pro	pro	ADJ
ajird-1356	35	5	-	-	ADJ
ajird-1356	35	6	inflammatory	inflammatory	ADJ
ajird-1356	35	7	cytokines	cytokine	NOUN
ajird-1356	35	8	such	such	ADJ
ajird-1356	35	9	as	as	ADP
ajird-1356	35	10	tumor	tumor	NOUN
ajird-1356	35	11	necrosis	necrosis	NOUN
ajird-1356	35	12	factor	factor	NOUN
ajird-1356	35	13	-	-	PUNCT
ajird-1356	35	14	alpha	alpha	NOUN
ajird-1356	35	15	(	(	PUNCT
ajird-1356	35	16	tnf	tnf	PROPN
ajird-1356	35	17	-	-	PUNCT
ajird-1356	35	18	α	α	NOUN
ajird-1356	35	19	)	)	PUNCT
ajird-1356	35	20	,	,	PUNCT
ajird-1356	35	21	interleukin-17	interleukin-17	PROPN
ajird-1356	35	22	(	(	PUNCT
ajird-1356	35	23	il-17	il-17	NUM
ajird-1356	35	24	)	)	PUNCT
ajird-1356	35	25	,	,	PUNCT
ajird-1356	35	26	and	and	CCONJ
ajird-1356	35	27	interleukin-6	interleukin-6	PROPN
ajird-1356	35	28	(	(	PUNCT
ajird-1356	35	29	il-6	il-6	NUM
ajird-1356	35	30	)	)	PUNCT
ajird-1356	35	31	,	,	PUNCT
ajird-1356	35	32	which	which	PRON
ajird-1356	35	33	play	play	VERB
ajird-1356	35	34	central	central	ADJ
ajird-1356	35	35	roles	role	NOUN
ajird-1356	35	36	in	in	ADP
ajird-1356	35	37	driving	drive	VERB
ajird-1356	35	38	inflammation	inflammation	NOUN
ajird-1356	35	39	in	in	ADP
ajird-1356	35	40	rea	rea	PROPN
ajird-1356	35	41	.	.	PUNCT
ajird-1356	36	1	the	the	DET
ajird-1356	36	2	immune	immune	ADJ
ajird-1356	36	3	response	response	NOUN
ajird-1356	36	4	in	in	ADP
ajird-1356	36	5	rea	rea	PROPN
ajird-1356	36	6	is	be	AUX
ajird-1356	36	7	primarily	primarily	ADV
ajird-1356	36	8	mediated	mediate	VERB
ajird-1356	36	9	by	by	ADP
ajird-1356	36	10	innate	innate	ADJ
ajird-1356	36	11	and	and	CCONJ
ajird-1356	36	12	adaptive	adaptive	ADJ
ajird-1356	36	13	immune	immune	ADJ
ajird-1356	36	14	cells	cell	NOUN
ajird-1356	36	15	that	that	PRON
ajird-1356	36	16	recognize	recognize	VERB
ajird-1356	36	17	and	and	CCONJ
ajird-1356	36	18	react	react	VERB
ajird-1356	36	19	to	to	ADP
ajird-1356	36	20	bacterial	bacterial	ADJ
ajird-1356	36	21	antigens	antigen	NOUN
ajird-1356	36	22	.	.	PUNCT
ajird-1356	37	1	cd8	cd8	PROPN
ajird-1356	37	2	+	+	PROPN
ajird-1356	37	3	t	t	PROPN
ajird-1356	37	4	cells	cell	NOUN
ajird-1356	37	5	are	be	AUX
ajird-1356	37	6	critical	critical	ADJ
ajird-1356	37	7	for	for	ADP
ajird-1356	37	8	the	the	DET
ajird-1356	37	9	cytotoxic	cytotoxic	ADJ
ajird-1356	37	10	response	response	NOUN
ajird-1356	37	11	in	in	ADP
ajird-1356	37	12	the	the	DET
ajird-1356	37	13	synovial	synovial	ADJ
ajird-1356	37	14	fluid	fluid	NOUN
ajird-1356	37	15	,	,	PUNCT
ajird-1356	37	16	recognizing	recognize	VERB
ajird-1356	37	17	bacterial	bacterial	ADJ
ajird-1356	37	18	antigens	antigen	NOUN
ajird-1356	37	19	presented	present	VERB
ajird-1356	37	20	by	by	ADP
ajird-1356	37	21	hla	hla	PROPN
ajird-1356	37	22	-	-	PUNCT
ajird-1356	37	23	b27	b27	PROPN
ajird-1356	37	24	.	.	PUNCT
ajird-1356	38	1	th1	th1	PROPN
ajird-1356	38	2	and	and	CCONJ
ajird-1356	38	3	th17	th17	PROPN
ajird-1356	38	4	responses	response	NOUN
ajird-1356	38	5	are	be	AUX
ajird-1356	38	6	elevated	elevate	VERB
ajird-1356	38	7	in	in	ADP
ajird-1356	38	8	rea	rea	PROPN
ajird-1356	38	9	,	,	PUNCT
ajird-1356	38	10	contributing	contribute	VERB
ajird-1356	38	11	to	to	ADP
ajird-1356	38	12	the	the	DET
ajird-1356	38	13	pro	pro	ADJ
ajird-1356	38	14	-	-	ADJ
ajird-1356	38	15	inflammatory	inflammatory	ADJ
ajird-1356	38	16	environment	environment	NOUN
ajird-1356	38	17	by	by	ADP
ajird-1356	38	18	producing	produce	VERB
ajird-1356	38	19	cytokines	cytokine	NOUN
ajird-1356	38	20	like	like	ADP
ajird-1356	38	21	american	american	ADJ
ajird-1356	38	22	journal	journal	PROPN
ajird-1356	38	23	of	of	ADP
ajird-1356	38	24	interdisciplinary	interdisciplinary	ADJ
ajird-1356	38	25	research	research	NOUN
ajird-1356	38	26	and	and	CCONJ
ajird-1356	38	27	development	development	NOUN
ajird-1356	38	28	issn	issn	PROPN
ajird-1356	38	29	online	online	NOUN
ajird-1356	38	30	:	:	PUNCT
ajird-1356	38	31	2771	2771	NUM
ajird-1356	38	32	-	-	SYM
ajird-1356	38	33	8948	8948	NUM
ajird-1356	38	34	website	website	NOUN
ajird-1356	38	35	:	:	PUNCT
ajird-1356	38	36	www.ajird.journalspark.org	www.ajird.journalspark.org	ADJ
ajird-1356	38	37	volume	volume	NOUN
ajird-1356	38	38	34	34	NUM
ajird-1356	38	39	,	,	PUNCT
ajird-1356	38	40	november	november	PROPN
ajird-1356	38	41	2024	2024	NUM
ajird-1356	38	42	33	33	NUM
ajird-1356	38	43	|	|	ADV
ajird-1356	38	44	p	p	NOUN
ajird-1356	38	45	a	a	DET
ajird-1356	38	46	g	g	NOUN
ajird-1356	38	47	e	e	NOUN
ajird-1356	38	48	ifn	ifn	NOUN
ajird-1356	38	49	-	-	PUNCT
ajird-1356	38	50	γ	γ	NOUN
ajird-1356	38	51	and	and	CCONJ
ajird-1356	38	52	il-17	il-17	X
ajird-1356	38	53	.	.	PUNCT
ajird-1356	39	1	macrophages	macrophage	NOUN
ajird-1356	39	2	and	and	CCONJ
ajird-1356	39	3	dendritic	dendritic	ADJ
ajird-1356	39	4	cells	cell	NOUN
ajird-1356	39	5	:	:	PUNCT
ajird-1356	39	6	these	these	DET
ajird-1356	39	7	antigen	antigen	NOUN
ajird-1356	39	8	-	-	PUNCT
ajird-1356	39	9	presenting	present	VERB
ajird-1356	39	10	cells	cell	NOUN
ajird-1356	39	11	(	(	PUNCT
ajird-1356	39	12	apcs	apc	NOUN
ajird-1356	39	13	)	)	PUNCT
ajird-1356	39	14	play	play	VERB
ajird-1356	39	15	an	an	DET
ajird-1356	39	16	essential	essential	ADJ
ajird-1356	39	17	role	role	NOUN
ajird-1356	39	18	by	by	ADP
ajird-1356	39	19	engulfing	engulf	VERB
ajird-1356	39	20	bacterial	bacterial	ADJ
ajird-1356	39	21	remnants	remnant	NOUN
ajird-1356	39	22	and	and	CCONJ
ajird-1356	39	23	presenting	present	VERB
ajird-1356	39	24	them	they	PRON
ajird-1356	39	25	to	to	ADP
ajird-1356	39	26	t	t	NOUN
ajird-1356	39	27	cells	cell	NOUN
ajird-1356	39	28	,	,	PUNCT
ajird-1356	39	29	perpetuating	perpetuate	VERB
ajird-1356	39	30	the	the	DET
ajird-1356	39	31	inflammatory	inflammatory	ADJ
ajird-1356	39	32	response	response	NOUN
ajird-1356	39	33	.	.	PUNCT
ajird-1356	40	1	neutrophils	neutrophil	NOUN
ajird-1356	40	2	are	be	AUX
ajird-1356	40	3	recruited	recruit	VERB
ajird-1356	40	4	to	to	ADP
ajird-1356	40	5	the	the	DET
ajird-1356	40	6	joints	joint	NOUN
ajird-1356	40	7	in	in	ADP
ajird-1356	40	8	response	response	NOUN
ajird-1356	40	9	to	to	ADP
ajird-1356	40	10	pro	pro	ADJ
ajird-1356	40	11	-	-	ADJ
ajird-1356	40	12	inflammatory	inflammatory	ADJ
ajird-1356	40	13	cytokines	cytokine	NOUN
ajird-1356	40	14	.	.	PUNCT
ajird-1356	41	1	they	they	PRON
ajird-1356	41	2	release	release	VERB
ajird-1356	41	3	reactive	reactive	ADJ
ajird-1356	41	4	oxygen	oxygen	NOUN
ajird-1356	41	5	species	specie	NOUN
ajird-1356	41	6	(	(	PUNCT
ajird-1356	41	7	ros	ros	PROPN
ajird-1356	41	8	)	)	PUNCT
ajird-1356	41	9	and	and	CCONJ
ajird-1356	41	10	enzymes	enzyme	NOUN
ajird-1356	41	11	that	that	PRON
ajird-1356	41	12	cause	cause	VERB
ajird-1356	41	13	tissue	tissue	NOUN
ajird-1356	41	14	damage	damage	NOUN
ajird-1356	41	15	and	and	CCONJ
ajird-1356	41	16	amplify	amplify	VERB
ajird-1356	41	17	inflammation	inflammation	NOUN
ajird-1356	41	18	.	.	PUNCT
ajird-1356	42	1	natural	natural	ADJ
ajird-1356	42	2	killer	killer	NOUN
ajird-1356	42	3	(	(	PUNCT
ajird-1356	42	4	nk	nk	PROPN
ajird-1356	42	5	)	)	PUNCT
ajird-1356	42	6	cells	cell	NOUN
ajird-1356	42	7	:	:	PUNCT
ajird-1356	42	8	nk	nk	PROPN
ajird-1356	42	9	cells	cell	NOUN
ajird-1356	42	10	are	be	AUX
ajird-1356	42	11	implicated	implicate	VERB
ajird-1356	42	12	in	in	ADP
ajird-1356	42	13	the	the	DET
ajird-1356	42	14	early	early	ADJ
ajird-1356	42	15	response	response	NOUN
ajird-1356	42	16	to	to	ADP
ajird-1356	42	17	infection	infection	NOUN
ajird-1356	42	18	and	and	CCONJ
ajird-1356	42	19	their	their	PRON
ajird-1356	42	20	dysregulated	dysregulated	ADJ
ajird-1356	42	21	activation	activation	NOUN
ajird-1356	42	22	may	may	AUX
ajird-1356	42	23	contribute	contribute	VERB
ajird-1356	42	24	to	to	ADP
ajird-1356	42	25	ongoing	ongoing	ADJ
ajird-1356	42	26	joint	joint	ADJ
ajird-1356	42	27	inflammation	inflammation	NOUN
ajird-1356	42	28	in	in	ADP
ajird-1356	42	29	rea	rea	PROPN
ajird-1356	42	30	.	.	PUNCT
ajird-1356	43	1	[	[	X
ajird-1356	43	2	2,3	2,3	NUM
ajird-1356	43	3	]	]	PUNCT
ajird-1356	43	4	.	.	PUNCT
ajird-1356	44	1	cytokines	cytokine	NOUN
ajird-1356	44	2	are	be	AUX
ajird-1356	44	3	crucial	crucial	ADJ
ajird-1356	44	4	mediators	mediator	NOUN
ajird-1356	44	5	of	of	ADP
ajird-1356	44	6	the	the	DET
ajird-1356	44	7	inflammatory	inflammatory	ADJ
ajird-1356	44	8	response	response	NOUN
ajird-1356	44	9	in	in	ADP
ajird-1356	44	10	rea	rea	PROPN
ajird-1356	44	11	.	.	PUNCT
ajird-1356	45	1	the	the	DET
ajird-1356	45	2	dysregulation	dysregulation	NOUN
ajird-1356	45	3	of	of	ADP
ajird-1356	45	4	pro	pro	ADJ
ajird-1356	45	5	-	-	ADJ
ajird-1356	45	6	inflammatory	inflammatory	ADJ
ajird-1356	45	7	cytokines	cytokine	NOUN
ajird-1356	45	8	leads	lead	VERB
ajird-1356	45	9	to	to	ADP
ajird-1356	45	10	chronic	chronic	ADJ
ajird-1356	45	11	inflammation	inflammation	NOUN
ajird-1356	45	12	,	,	PUNCT
ajird-1356	45	13	joint	joint	ADJ
ajird-1356	45	14	damage	damage	NOUN
ajird-1356	45	15	,	,	PUNCT
ajird-1356	45	16	and	and	CCONJ
ajird-1356	45	17	disease	disease	NOUN
ajird-1356	45	18	progression	progression	NOUN
ajird-1356	45	19	.	.	PUNCT
ajird-1356	46	1	tumor	tumor	NOUN
ajird-1356	46	2	necrosis	necrosis	NOUN
ajird-1356	46	3	factor	factor	NOUN
ajird-1356	46	4	-	-	PUNCT
ajird-1356	46	5	alpha	alpha	NOUN
ajird-1356	46	6	(	(	PUNCT
ajird-1356	46	7	tnf	tnf	PROPN
ajird-1356	46	8	-	-	PUNCT
ajird-1356	46	9	α	α	PROPN
ajird-1356	46	10	):	):	PUNCT
ajird-1356	46	11	tnf	tnf	PROPN
ajird-1356	46	12	-	-	PUNCT
ajird-1356	46	13	α	α	PROPN
ajird-1356	46	14	is	be	AUX
ajird-1356	46	15	a	a	DET
ajird-1356	46	16	master	master	NOUN
ajird-1356	46	17	regulator	regulator	NOUN
ajird-1356	46	18	of	of	ADP
ajird-1356	46	19	inflammation	inflammation	NOUN
ajird-1356	46	20	,	,	PUNCT
ajird-1356	46	21	promoting	promote	VERB
ajird-1356	46	22	the	the	DET
ajird-1356	46	23	recruitment	recruitment	NOUN
ajird-1356	46	24	of	of	ADP
ajird-1356	46	25	immune	immune	ADJ
ajird-1356	46	26	cells	cell	NOUN
ajird-1356	46	27	to	to	ADP
ajird-1356	46	28	the	the	DET
ajird-1356	46	29	synovial	synovial	ADJ
ajird-1356	46	30	joints	joint	NOUN
ajird-1356	46	31	and	and	CCONJ
ajird-1356	46	32	the	the	DET
ajird-1356	46	33	production	production	NOUN
ajird-1356	46	34	of	of	ADP
ajird-1356	46	35	other	other	ADJ
ajird-1356	46	36	proinflammatory	proinflammatory	ADJ
ajird-1356	46	37	cytokines	cytokine	NOUN
ajird-1356	46	38	.	.	PUNCT
ajird-1356	47	1	interleukin-17	interleukin-17	ADV
ajird-1356	47	2	(	(	PUNCT
ajird-1356	47	3	il-17	il-17	NUM
ajird-1356	47	4	):	):	PUNCT
ajird-1356	47	5	il-17	il-17	NUM
ajird-1356	47	6	,	,	PUNCT
ajird-1356	47	7	produced	produce	VERB
ajird-1356	47	8	by	by	ADP
ajird-1356	47	9	th17	th17	NOUN
ajird-1356	47	10	cells	cell	NOUN
ajird-1356	47	11	,	,	PUNCT
ajird-1356	47	12	has	have	AUX
ajird-1356	47	13	emerged	emerge	VERB
ajird-1356	47	14	as	as	ADP
ajird-1356	47	15	a	a	DET
ajird-1356	47	16	key	key	ADJ
ajird-1356	47	17	player	player	NOUN
ajird-1356	47	18	in	in	ADP
ajird-1356	47	19	autoimmune	autoimmune	ADJ
ajird-1356	47	20	diseases	disease	NOUN
ajird-1356	47	21	,	,	PUNCT
ajird-1356	47	22	including	include	VERB
ajird-1356	47	23	rea	rea	PROPN
ajird-1356	47	24	.	.	PUNCT
ajird-1356	48	1	it	it	PRON
ajird-1356	48	2	promotes	promote	VERB
ajird-1356	48	3	the	the	DET
ajird-1356	48	4	recruitment	recruitment	NOUN
ajird-1356	48	5	of	of	ADP
ajird-1356	48	6	neutrophils	neutrophil	NOUN
ajird-1356	48	7	and	and	CCONJ
ajird-1356	48	8	enhances	enhance	VERB
ajird-1356	48	9	tissue	tissue	NOUN
ajird-1356	48	10	inflammation	inflammation	NOUN
ajird-1356	48	11	.	.	PUNCT
ajird-1356	49	1	interleukin-6	interleukin-6	NUM
ajird-1356	49	2	(	(	PUNCT
ajird-1356	49	3	il-6	il-6	NUM
ajird-1356	49	4	):	):	PUNCT
ajird-1356	49	5	il-6	il-6	PRON
ajird-1356	49	6	promotes	promote	VERB
ajird-1356	49	7	local	local	ADJ
ajird-1356	49	8	inflammation	inflammation	NOUN
ajird-1356	49	9	and	and	CCONJ
ajird-1356	49	10	is	be	AUX
ajird-1356	49	11	responsible	responsible	ADJ
ajird-1356	49	12	for	for	ADP
ajird-1356	49	13	inducing	induce	VERB
ajird-1356	49	14	acute	acute	ADJ
ajird-1356	49	15	-	-	PUNCT
ajird-1356	49	16	phase	phase	NOUN
ajird-1356	49	17	responses	response	NOUN
ajird-1356	49	18	and	and	CCONJ
ajird-1356	49	19	systemic	systemic	ADJ
ajird-1356	49	20	effects	effect	NOUN
ajird-1356	49	21	such	such	ADJ
ajird-1356	49	22	as	as	ADP
ajird-1356	49	23	fever	fever	NOUN
ajird-1356	49	24	and	and	CCONJ
ajird-1356	49	25	fatigue	fatigue	NOUN
ajird-1356	49	26	.	.	PUNCT
ajird-1356	50	1	interleukin-23	interleukin-23	PROPN
ajird-1356	50	2	(	(	PUNCT
ajird-1356	50	3	il-23	il-23	NOUN
ajird-1356	50	4	):	):	PUNCT
ajird-1356	50	5	il-23	il-23	NOUN
ajird-1356	50	6	is	be	AUX
ajird-1356	50	7	involved	involve	VERB
ajird-1356	50	8	in	in	ADP
ajird-1356	50	9	the	the	DET
ajird-1356	50	10	differentiation	differentiation	NOUN
ajird-1356	50	11	and	and	CCONJ
ajird-1356	50	12	maintenance	maintenance	NOUN
ajird-1356	50	13	of	of	ADP
ajird-1356	50	14	th17	th17	NOUN
ajird-1356	50	15	cells	cell	NOUN
ajird-1356	50	16	,	,	PUNCT
ajird-1356	50	17	which	which	PRON
ajird-1356	50	18	are	be	AUX
ajird-1356	50	19	central	central	ADJ
ajird-1356	50	20	to	to	ADP
ajird-1356	50	21	the	the	DET
ajird-1356	50	22	il-17	il-17	ADV
ajird-1356	50	23	-	-	PUNCT
ajird-1356	50	24	mediated	mediate	VERB
ajird-1356	50	25	inflammatory	inflammatory	ADJ
ajird-1356	50	26	response	response	NOUN
ajird-1356	50	27	.	.	PUNCT
ajird-1356	51	1	the	the	DET
ajird-1356	51	2	tnf	tnf	PROPN
ajird-1356	51	3	-	-	PUNCT
ajird-1356	51	4	α	α	NOUN
ajird-1356	51	5	/	/	SYM
ajird-1356	51	6	il-23	il-23	NOUN
ajird-1356	51	7	/	/	SYM
ajird-1356	51	8	il-17	il-17	NUM
ajird-1356	51	9	axis	axis	NOUN
ajird-1356	51	10	is	be	AUX
ajird-1356	51	11	particularly	particularly	ADV
ajird-1356	51	12	critical	critical	ADJ
ajird-1356	51	13	in	in	ADP
ajird-1356	51	14	the	the	DET
ajird-1356	51	15	pathogenesis	pathogenesis	NOUN
ajird-1356	51	16	of	of	ADP
ajird-1356	51	17	rea	rea	PROPN
ajird-1356	51	18	and	and	CCONJ
ajird-1356	51	19	has	have	AUX
ajird-1356	51	20	become	become	VERB
ajird-1356	51	21	a	a	DET
ajird-1356	51	22	target	target	NOUN
ajird-1356	51	23	for	for	ADP
ajird-1356	51	24	biologic	biologic	NOUN
ajird-1356	51	25	therapies	therapy	NOUN
ajird-1356	51	26	such	such	ADJ
ajird-1356	51	27	as	as	ADP
ajird-1356	51	28	tnf	tnf	PROPN
ajird-1356	51	29	inhibitors	inhibitor	NOUN
ajird-1356	51	30	and	and	CCONJ
ajird-1356	51	31	il-17	il-17	ADV
ajird-1356	51	32	inhibitors	inhibitor	NOUN
ajird-1356	51	33	.	.	PUNCT
ajird-1356	52	1	[	[	X
ajird-1356	52	2	3,4	3,4	NUM
ajird-1356	52	3	]	]	PUNCT
ajird-1356	52	4	in	in	ADP
ajird-1356	52	5	rea	rea	PROPN
ajird-1356	52	6	,	,	PUNCT
ajird-1356	52	7	immune	immune	ADJ
ajird-1356	52	8	dysregulation	dysregulation	NOUN
ajird-1356	52	9	is	be	AUX
ajird-1356	52	10	specifically	specifically	ADV
ajird-1356	52	11	localized	localize	VERB
ajird-1356	52	12	in	in	ADP
ajird-1356	52	13	the	the	DET
ajird-1356	52	14	synovium	synovium	NOUN
ajird-1356	52	15	,	,	PUNCT
ajird-1356	52	16	the	the	DET
ajird-1356	52	17	membrane	membrane	NOUN
ajird-1356	52	18	lining	line	VERB
ajird-1356	52	19	the	the	DET
ajird-1356	52	20	joints	joint	NOUN
ajird-1356	52	21	.	.	PUNCT
ajird-1356	53	1	once	once	SCONJ
ajird-1356	53	2	bacterial	bacterial	ADJ
ajird-1356	53	3	antigens	antigen	NOUN
ajird-1356	53	4	are	be	AUX
ajird-1356	53	5	introduced	introduce	VERB
ajird-1356	53	6	into	into	ADP
ajird-1356	53	7	the	the	DET
ajird-1356	53	8	synovium	synovium	NOUN
ajird-1356	53	9	,	,	PUNCT
ajird-1356	53	10	they	they	PRON
ajird-1356	53	11	are	be	AUX
ajird-1356	53	12	presented	present	VERB
ajird-1356	53	13	by	by	ADP
ajird-1356	53	14	synovial	synovial	ADJ
ajird-1356	53	15	macrophages	macrophage	NOUN
ajird-1356	53	16	and	and	CCONJ
ajird-1356	53	17	dendritic	dendritic	ADJ
ajird-1356	53	18	cells	cell	NOUN
ajird-1356	53	19	,	,	PUNCT
ajird-1356	53	20	which	which	PRON
ajird-1356	53	21	activate	activate	VERB
ajird-1356	53	22	cd4	cd4	PROPN
ajird-1356	53	23	+	+	PROPN
ajird-1356	53	24	and	and	CCONJ
ajird-1356	53	25	cd8	cd8	PROPN
ajird-1356	53	26	+	+	PROPN
ajird-1356	53	27	t	t	NOUN
ajird-1356	53	28	cells	cell	NOUN
ajird-1356	53	29	.	.	PUNCT
ajird-1356	54	1	this	this	PRON
ajird-1356	54	2	leads	lead	VERB
ajird-1356	54	3	to	to	ADP
ajird-1356	54	4	local	local	ADJ
ajird-1356	54	5	inflammation	inflammation	NOUN
ajird-1356	54	6	characterized	characterize	VERB
ajird-1356	54	7	by	by	ADP
ajird-1356	54	8	the	the	DET
ajird-1356	54	9	following	follow	VERB
ajird-1356	54	10	processes	process	NOUN
ajird-1356	54	11	:	:	PUNCT
ajird-1356	54	12	synovial	synovial	ADJ
ajird-1356	54	13	hyperplasia	hyperplasia	NOUN
ajird-1356	54	14	:	:	PUNCT
ajird-1356	54	15	prolonged	prolong	VERB
ajird-1356	54	16	inflammation	inflammation	NOUN
ajird-1356	54	17	causes	cause	VERB
ajird-1356	54	18	the	the	DET
ajird-1356	54	19	thickening	thickening	NOUN
ajird-1356	54	20	of	of	ADP
ajird-1356	54	21	the	the	DET
ajird-1356	54	22	synovial	synovial	ADJ
ajird-1356	54	23	membrane	membrane	NOUN
ajird-1356	54	24	,	,	PUNCT
ajird-1356	54	25	leading	lead	VERB
ajird-1356	54	26	to	to	ADP
ajird-1356	54	27	the	the	DET
ajird-1356	54	28	characteristic	characteristic	ADJ
ajird-1356	54	29	swelling	swelling	NOUN
ajird-1356	54	30	and	and	CCONJ
ajird-1356	54	31	pain	pain	NOUN
ajird-1356	54	32	seen	see	VERB
ajird-1356	54	33	in	in	ADP
ajird-1356	54	34	rea	rea	PROPN
ajird-1356	54	35	.	.	PROPN
ajird-1356	54	36	cartilage	cartilage	NOUN
ajird-1356	54	37	and	and	CCONJ
ajird-1356	54	38	bone	bone	NOUN
ajird-1356	54	39	damage	damage	NOUN
ajird-1356	54	40	:	:	PUNCT
ajird-1356	54	41	persistent	persistent	ADJ
ajird-1356	54	42	inflammation	inflammation	NOUN
ajird-1356	54	43	results	result	NOUN
ajird-1356	54	44	in	in	ADP
ajird-1356	54	45	the	the	DET
ajird-1356	54	46	activation	activation	NOUN
ajird-1356	54	47	of	of	ADP
ajird-1356	54	48	osteoclasts	osteoclast	NOUN
ajird-1356	54	49	(	(	PUNCT
ajird-1356	54	50	cells	cell	NOUN
ajird-1356	54	51	that	that	PRON
ajird-1356	54	52	break	break	VERB
ajird-1356	54	53	down	down	ADP
ajird-1356	54	54	bone	bone	NOUN
ajird-1356	54	55	tissue	tissue	NOUN
ajird-1356	54	56	)	)	PUNCT
ajird-1356	54	57	and	and	CCONJ
ajird-1356	54	58	damage	damage	NOUN
ajird-1356	54	59	to	to	ADP
ajird-1356	54	60	cartilage	cartilage	NOUN
ajird-1356	54	61	,	,	PUNCT
ajird-1356	54	62	potentially	potentially	ADV
ajird-1356	54	63	leading	lead	VERB
ajird-1356	54	64	to	to	ADP
ajird-1356	54	65	joint	joint	ADJ
ajird-1356	54	66	erosion	erosion	NOUN
ajird-1356	54	67	and	and	CCONJ
ajird-1356	54	68	deformities.[5	deformities.[5	NOUN
ajird-1356	54	69	]	]	X
ajird-1356	54	70	.	.	PUNCT
ajird-1356	55	1	the	the	DET
ajird-1356	55	2	immune	immune	ADJ
ajird-1356	55	3	mechanisms	mechanism	NOUN
ajird-1356	55	4	involved	involve	VERB
ajird-1356	55	5	in	in	ADP
ajird-1356	55	6	rea	rea	PROPN
ajird-1356	55	7	are	be	AUX
ajird-1356	55	8	not	not	PART
ajird-1356	55	9	confined	confine	VERB
ajird-1356	55	10	to	to	ADP
ajird-1356	55	11	the	the	DET
ajird-1356	55	12	joints	joint	NOUN
ajird-1356	55	13	.	.	PUNCT
ajird-1356	56	1	extra	extra	ADJ
ajird-1356	56	2	-	-	ADJ
ajird-1356	56	3	articular	articular	ADJ
ajird-1356	56	4	manifestations	manifestation	NOUN
ajird-1356	56	5	such	such	ADJ
ajird-1356	56	6	as	as	ADP
ajird-1356	56	7	conjunctivitis	conjunctivitis	NOUN
ajird-1356	56	8	,	,	PUNCT
ajird-1356	56	9	uveitis	uveitis	NOUN
ajird-1356	56	10	,	,	PUNCT
ajird-1356	56	11	and	and	CCONJ
ajird-1356	56	12	skin	skin	NOUN
ajird-1356	56	13	lesions	lesion	NOUN
ajird-1356	56	14	are	be	AUX
ajird-1356	56	15	common	common	ADJ
ajird-1356	56	16	,	,	PUNCT
ajird-1356	56	17	reflecting	reflect	VERB
ajird-1356	56	18	the	the	DET
ajird-1356	56	19	systemic	systemic	ADJ
ajird-1356	56	20	nature	nature	NOUN
ajird-1356	56	21	of	of	ADP
ajird-1356	56	22	the	the	DET
ajird-1356	56	23	immune	immune	ADJ
ajird-1356	56	24	dysregulation	dysregulation	NOUN
ajird-1356	56	25	.	.	PUNCT
ajird-1356	57	1	these	these	DET
ajird-1356	57	2	manifestations	manifestation	NOUN
ajird-1356	57	3	are	be	AUX
ajird-1356	57	4	driven	drive	VERB
ajird-1356	57	5	by	by	ADP
ajird-1356	57	6	the	the	DET
ajird-1356	57	7	same	same	ADJ
ajird-1356	57	8	immune	immune	ADJ
ajird-1356	57	9	pathways	pathway	NOUN
ajird-1356	57	10	(	(	PUNCT
ajird-1356	57	11	e.g.	e.g.	ADV
ajird-1356	57	12	,	,	PUNCT
ajird-1356	57	13	tnf	tnf	PROPN
ajird-1356	57	14	-	-	PUNCT
ajird-1356	57	15	α	α	PROPN
ajird-1356	57	16	,	,	PUNCT
ajird-1356	57	17	il-17	il-17	X
ajird-1356	57	18	)	)	PUNCT
ajird-1356	57	19	and	and	CCONJ
ajird-1356	57	20	often	often	ADV
ajird-1356	57	21	involve	involve	VERB
ajird-1356	57	22	similar	similar	ADJ
ajird-1356	57	23	immune	immune	ADJ
ajird-1356	57	24	cells	cell	NOUN
ajird-1356	57	25	infiltrating	infiltrate	VERB
ajird-1356	57	26	extra	extra	ADJ
ajird-1356	57	27	-	-	ADJ
ajird-1356	57	28	articular	articular	ADJ
ajird-1356	57	29	tissues	tissue	NOUN
ajird-1356	57	30	.	.	PUNCT
ajird-1356	58	1	in	in	ADP
ajird-1356	58	2	many	many	ADJ
ajird-1356	58	3	patients	patient	NOUN
ajird-1356	58	4	,	,	PUNCT
ajird-1356	58	5	rea	rea	PROPN
ajird-1356	58	6	is	be	AUX
ajird-1356	58	7	self	self	NOUN
ajird-1356	58	8	-	-	PUNCT
ajird-1356	58	9	limiting	limit	VERB
ajird-1356	58	10	,	,	PUNCT
ajird-1356	58	11	but	but	CCONJ
ajird-1356	58	12	in	in	ADP
ajird-1356	58	13	15	15	NUM
ajird-1356	58	14	-	-	SYM
ajird-1356	58	15	30	30	NUM
ajird-1356	58	16	%	%	NOUN
ajird-1356	58	17	of	of	ADP
ajird-1356	58	18	cases	case	NOUN
ajird-1356	58	19	,	,	PUNCT
ajird-1356	58	20	it	it	PRON
ajird-1356	58	21	becomes	become	VERB
ajird-1356	58	22	chronic	chronic	ADJ
ajird-1356	58	23	or	or	CCONJ
ajird-1356	58	24	recurrent	recurrent	NOUN
ajird-1356	58	25	.	.	PUNCT
ajird-1356	59	1	the	the	DET
ajird-1356	59	2	reasons	reason	NOUN
ajird-1356	59	3	for	for	ADP
ajird-1356	59	4	chronicity	chronicity	NOUN
ajird-1356	59	5	are	be	AUX
ajird-1356	59	6	not	not	PART
ajird-1356	59	7	fully	fully	ADV
ajird-1356	59	8	understood	understand	VERB
ajird-1356	59	9	but	but	CCONJ
ajird-1356	59	10	may	may	AUX
ajird-1356	59	11	involve	involve	VERB
ajird-1356	59	12	:	:	PUNCT
ajird-1356	59	13	persistent	persistent	ADJ
ajird-1356	59	14	infection	infection	NOUN
ajird-1356	59	15	:	:	PUNCT
ajird-1356	59	16	in	in	ADP
ajird-1356	59	17	some	some	DET
ajird-1356	59	18	cases	case	NOUN
ajird-1356	59	19	,	,	PUNCT
ajird-1356	59	20	the	the	DET
ajird-1356	59	21	causative	causative	ADJ
ajird-1356	59	22	pathogen	pathogen	NOUN
ajird-1356	59	23	may	may	AUX
ajird-1356	59	24	not	not	PART
ajird-1356	59	25	be	be	AUX
ajird-1356	59	26	fully	fully	ADV
ajird-1356	59	27	eradicated	eradicate	VERB
ajird-1356	59	28	,	,	PUNCT
ajird-1356	59	29	allowing	allow	VERB
ajird-1356	59	30	for	for	ADP
ajird-1356	59	31	ongoing	ongoing	ADJ
ajird-1356	59	32	antigen	antigen	ADJ
ajird-1356	59	33	presentation	presentation	NOUN
ajird-1356	59	34	and	and	CCONJ
ajird-1356	59	35	immune	immune	ADJ
ajird-1356	59	36	activation	activation	NOUN
ajird-1356	59	37	.	.	PUNCT
ajird-1356	60	1	autoimmunity	autoimmunity	NOUN
ajird-1356	60	2	:	:	PUNCT
ajird-1356	60	3	continued	continue	VERB
ajird-1356	60	4	immune	immune	ADJ
ajird-1356	60	5	activation	activation	NOUN
ajird-1356	60	6	,	,	PUNCT
ajird-1356	60	7	possibly	possibly	ADV
ajird-1356	60	8	driven	drive	VERB
ajird-1356	60	9	by	by	ADP
ajird-1356	60	10	molecular	molecular	ADJ
ajird-1356	60	11	mimicry	mimicry	NOUN
ajird-1356	60	12	,	,	PUNCT
ajird-1356	60	13	may	may	AUX
ajird-1356	60	14	lead	lead	VERB
ajird-1356	60	15	to	to	ADP
ajird-1356	60	16	an	an	DET
ajird-1356	60	17	autoimmune	autoimmune	ADJ
ajird-1356	60	18	process	process	NOUN
ajird-1356	60	19	where	where	SCONJ
ajird-1356	60	20	the	the	DET
ajird-1356	60	21	immune	immune	ADJ
ajird-1356	60	22	system	system	NOUN
ajird-1356	60	23	attacks	attack	VERB
ajird-1356	60	24	the	the	DET
ajird-1356	60	25	body	body	NOUN
ajird-1356	60	26	’s	’s	PART
ajird-1356	60	27	own	own	ADJ
ajird-1356	60	28	tissues	tissue	NOUN
ajird-1356	60	29	long	long	ADV
ajird-1356	60	30	after	after	SCONJ
ajird-1356	60	31	the	the	DET
ajird-1356	60	32	infection	infection	NOUN
ajird-1356	60	33	has	have	AUX
ajird-1356	60	34	been	be	AUX
ajird-1356	60	35	cleared	clear	VERB
ajird-1356	60	36	.	.	PUNCT
ajird-1356	61	1	genetic	genetic	ADJ
ajird-1356	61	2	factors	factor	NOUN
ajird-1356	61	3	:	:	PUNCT
ajird-1356	61	4	hla	hla	NOUN
ajird-1356	61	5	-	-	PUNCT
ajird-1356	61	6	b27	b27	PROPN
ajird-1356	61	7	-	-	PUNCT
ajird-1356	61	8	positive	positive	ADJ
ajird-1356	61	9	individuals	individual	NOUN
ajird-1356	61	10	are	be	AUX
ajird-1356	61	11	more	more	ADV
ajird-1356	61	12	likely	likely	ADJ
ajird-1356	61	13	to	to	PART
ajird-1356	61	14	develop	develop	VERB
ajird-1356	61	15	chronic	chronic	ADJ
ajird-1356	61	16	or	or	CCONJ
ajird-1356	61	17	recurrent	recurrent	ADJ
ajird-1356	61	18	rea.[6	rea.[6	PROPN
ajird-1356	61	19	]	]	PUNCT
ajird-1356	61	20	.	.	PUNCT
ajird-1356	62	1	a	a	DET
ajird-1356	62	2	systematic	systematic	ADJ
ajird-1356	62	3	literature	literature	NOUN
ajird-1356	62	4	search	search	NOUN
ajird-1356	62	5	was	be	AUX
ajird-1356	62	6	conducted	conduct	VERB
ajird-1356	62	7	using	use	VERB
ajird-1356	62	8	pubmed	pubmed	PROPN
ajird-1356	62	9	,	,	PUNCT
ajird-1356	62	10	scopus	scopus	PROPN
ajird-1356	62	11	,	,	PUNCT
ajird-1356	62	12	and	and	CCONJ
ajird-1356	62	13	cochrane	cochrane	NOUN
ajird-1356	62	14	databases	database	NOUN
ajird-1356	62	15	for	for	ADP
ajird-1356	62	16	studies	study	NOUN
ajird-1356	62	17	published	publish	VERB
ajird-1356	62	18	from	from	ADP
ajird-1356	62	19	american	american	ADJ
ajird-1356	62	20	journal	journal	PROPN
ajird-1356	62	21	of	of	ADP
ajird-1356	62	22	interdisciplinary	interdisciplinary	ADJ
ajird-1356	62	23	research	research	NOUN
ajird-1356	62	24	and	and	CCONJ
ajird-1356	62	25	development	development	NOUN
ajird-1356	62	26	issn	issn	PROPN
ajird-1356	62	27	online	online	NOUN
ajird-1356	62	28	:	:	PUNCT
ajird-1356	62	29	2771	2771	NUM
ajird-1356	62	30	-	-	SYM
ajird-1356	62	31	8948	8948	NUM
ajird-1356	62	32	website	website	NOUN
ajird-1356	62	33	:	:	PUNCT
ajird-1356	62	34	www.ajird.journalspark.org	www.ajird.journalspark.org	ADJ
ajird-1356	62	35	volume	volume	NOUN
ajird-1356	62	36	34	34	NUM
ajird-1356	62	37	,	,	PUNCT
ajird-1356	62	38	november	november	PROPN
ajird-1356	62	39	2024	2024	NUM
ajird-1356	62	40	34	34	NUM
ajird-1356	63	1	|	|	ADV
ajird-1356	63	2	p	p	NOUN
ajird-1356	63	3	a	a	DET
ajird-1356	63	4	g	g	NOUN
ajird-1356	63	5	e	e	NOUN
ajird-1356	63	6	2018	2018	NUM
ajird-1356	63	7	to	to	ADP
ajird-1356	63	8	2024	2024	NUM
ajird-1356	63	9	.	.	PUNCT
ajird-1356	64	1	the	the	DET
ajird-1356	64	2	search	search	NOUN
ajird-1356	64	3	terms	term	NOUN
ajird-1356	64	4	included	include	VERB
ajird-1356	64	5	"	"	PUNCT
ajird-1356	64	6	reactive	reactive	ADJ
ajird-1356	64	7	arthritis	arthritis	NOUN
ajird-1356	64	8	,	,	PUNCT
ajird-1356	64	9	"	"	PUNCT
ajird-1356	64	10	"	"	PUNCT
ajird-1356	64	11	prevalence	prevalence	NOUN
ajird-1356	64	12	,	,	PUNCT
ajird-1356	64	13	"	"	PUNCT
ajird-1356	64	14	"	"	PUNCT
ajird-1356	64	15	hla	hla	NOUN
ajird-1356	64	16	-	-	PUNCT
ajird-1356	64	17	b27	b27	NOUN
ajird-1356	64	18	,	,	PUNCT
ajird-1356	64	19	"	"	PUNCT
ajird-1356	64	20	"	"	PUNCT
ajird-1356	64	21	treatment	treatment	NOUN
ajird-1356	64	22	,	,	PUNCT
ajird-1356	64	23	"	"	PUNCT
ajird-1356	64	24	"	"	PUNCT
ajird-1356	64	25	biologics	biologic	NOUN
ajird-1356	64	26	,	,	PUNCT
ajird-1356	64	27	"	"	PUNCT
ajird-1356	64	28	and	and	CCONJ
ajird-1356	64	29	"	"	PUNCT
ajird-1356	64	30	dmards	dmard	NOUN
ajird-1356	64	31	.	.	PUNCT
ajird-1356	64	32	"	"	PUNCT
ajird-1356	65	1	inclusion	inclusion	NOUN
ajird-1356	65	2	criteria	criterion	NOUN
ajird-1356	65	3	were	be	AUX
ajird-1356	65	4	:	:	PUNCT
ajird-1356	65	5	1.rea	1.rea	AUX
ajird-1356	65	6	diagnosed	diagnose	VERB
ajird-1356	65	7	according	accord	VERB
ajird-1356	65	8	to	to	ADP
ajird-1356	65	9	established	establish	VERB
ajird-1356	65	10	clinical	clinical	ADJ
ajird-1356	65	11	criteria	criterion	NOUN
ajird-1356	65	12	.	.	PUNCT
ajird-1356	66	1	2.studies	2.studies	NUM
ajird-1356	66	2	including	include	VERB
ajird-1356	66	3	at	at	ADV
ajird-1356	66	4	least	least	ADV
ajird-1356	66	5	30	30	NUM
ajird-1356	66	6	patients	patient	NOUN
ajird-1356	66	7	with	with	ADP
ajird-1356	66	8	follow	follow	NOUN
ajird-1356	66	9	-	-	PUNCT
ajird-1356	66	10	up	up	NOUN
ajird-1356	66	11	of	of	ADP
ajird-1356	66	12	6	6	NUM
ajird-1356	66	13	months	month	NOUN
ajird-1356	66	14	or	or	CCONJ
ajird-1356	66	15	more	more	ADJ
ajird-1356	66	16	.	.	PUNCT
ajird-1356	67	1	3.reported	3.reported	NUM
ajird-1356	67	2	outcomes	outcome	NOUN
ajird-1356	67	3	on	on	ADP
ajird-1356	67	4	treatment	treatment	NOUN
ajird-1356	67	5	efficacy	efficacy	NOUN
ajird-1356	67	6	or	or	CCONJ
ajird-1356	67	7	genetic	genetic	ADJ
ajird-1356	67	8	associations	association	NOUN
ajird-1356	67	9	.	.	PUNCT
ajird-1356	68	1	a	a	DET
ajird-1356	68	2	random	random	ADJ
ajird-1356	68	3	-	-	PUNCT
ajird-1356	68	4	effects	effect	NOUN
ajird-1356	68	5	model	model	NOUN
ajird-1356	68	6	was	be	AUX
ajird-1356	68	7	applied	apply	VERB
ajird-1356	68	8	due	due	ADJ
ajird-1356	68	9	to	to	ADP
ajird-1356	68	10	expected	expect	VERB
ajird-1356	68	11	heterogeneity	heterogeneity	NOUN
ajird-1356	68	12	among	among	ADP
ajird-1356	68	13	studies	study	NOUN
ajird-1356	68	14	.	.	PUNCT
ajird-1356	69	1	prevalence	prevalence	NOUN
ajird-1356	69	2	rates	rate	NOUN
ajird-1356	69	3	,	,	PUNCT
ajird-1356	69	4	relative	relative	ADJ
ajird-1356	69	5	risks	risk	NOUN
ajird-1356	69	6	(	(	PUNCT
ajird-1356	69	7	rr	rr	NOUN
ajird-1356	69	8	)	)	PUNCT
ajird-1356	69	9	,	,	PUNCT
ajird-1356	69	10	and	and	CCONJ
ajird-1356	69	11	odds	odd	NOUN
ajird-1356	69	12	ratios	ratio	NOUN
ajird-1356	69	13	(	(	PUNCT
ajird-1356	69	14	or	or	CCONJ
ajird-1356	69	15	)	)	PUNCT
ajird-1356	69	16	were	be	AUX
ajird-1356	69	17	calculated	calculate	VERB
ajird-1356	69	18	with	with	ADP
ajird-1356	69	19	95	95	NUM
ajird-1356	69	20	%	%	NOUN
ajird-1356	69	21	confidence	confidence	NOUN
ajird-1356	69	22	intervals	interval	NOUN
ajird-1356	69	23	(	(	PUNCT
ajird-1356	69	24	cis	cis	NOUN
ajird-1356	69	25	)	)	PUNCT
ajird-1356	69	26	.	.	PUNCT
ajird-1356	70	1	heterogeneity	heterogeneity	NOUN
ajird-1356	70	2	was	be	AUX
ajird-1356	70	3	quantified	quantify	VERB
ajird-1356	70	4	using	use	VERB
ajird-1356	70	5	i²	i²	NOUN
ajird-1356	70	6	statistics	statistic	NOUN
ajird-1356	70	7	,	,	PUNCT
ajird-1356	70	8	with	with	ADP
ajird-1356	70	9	values	value	NOUN
ajird-1356	70	10	>	>	X
ajird-1356	70	11	50	50	NUM
ajird-1356	70	12	%	%	NOUN
ajird-1356	70	13	indicating	indicate	VERB
ajird-1356	70	14	substantial	substantial	ADJ
ajird-1356	70	15	heterogeneity	heterogeneity	NOUN
ajird-1356	70	16	.	.	PUNCT
ajird-1356	71	1	results	result	VERB
ajird-1356	71	2	prevalence	prevalence	NOUN
ajird-1356	71	3	of	of	ADP
ajird-1356	71	4	rea	rea	PROPN
ajird-1356	71	5	following	follow	VERB
ajird-1356	71	6	infection	infection	NOUN
ajird-1356	71	7	.	.	PUNCT
ajird-1356	72	1	eight	eight	NUM
ajird-1356	72	2	studies	study	NOUN
ajird-1356	72	3	evaluated	evaluate	VERB
ajird-1356	72	4	the	the	DET
ajird-1356	72	5	prevalence	prevalence	NOUN
ajird-1356	72	6	of	of	ADP
ajird-1356	72	7	rea	rea	PROPN
ajird-1356	72	8	following	follow	VERB
ajird-1356	72	9	infection	infection	NOUN
ajird-1356	72	10	with	with	ADP
ajird-1356	72	11	common	common	ADJ
ajird-1356	72	12	pathogens	pathogen	NOUN
ajird-1356	72	13	.	.	PUNCT
ajird-1356	73	1	the	the	DET
ajird-1356	73	2	pooled	pooled	ADJ
ajird-1356	73	3	prevalence	prevalence	NOUN
ajird-1356	73	4	of	of	ADP
ajird-1356	73	5	rea	rea	PROPN
ajird-1356	73	6	was	be	AUX
ajird-1356	73	7	11.6	11.6	NUM
ajird-1356	73	8	%	%	NOUN
ajird-1356	73	9	(	(	PUNCT
ajird-1356	73	10	95	95	NUM
ajird-1356	73	11	%	%	NOUN
ajird-1356	73	12	ci	ci	NOUN
ajird-1356	73	13	:	:	PUNCT
ajird-1356	73	14	9.2–14.4	9.2–14.4	NUM
ajird-1356	73	15	%	%	NOUN
ajird-1356	73	16	)	)	PUNCT
ajird-1356	73	17	across	across	ADP
ajird-1356	73	18	7,582	7,582	NUM
ajird-1356	73	19	patients	patient	NOUN
ajird-1356	73	20	who	who	PRON
ajird-1356	73	21	experienced	experience	VERB
ajird-1356	73	22	enteric	enteric	ADJ
ajird-1356	73	23	or	or	CCONJ
ajird-1356	73	24	genitourinary	genitourinary	ADJ
ajird-1356	73	25	infections	infection	NOUN
ajird-1356	73	26	.	.	PUNCT
ajird-1356	74	1	the	the	DET
ajird-1356	74	2	breakdown	breakdown	NOUN
ajird-1356	74	3	by	by	ADP
ajird-1356	74	4	pathogen	pathogen	NOUN
ajird-1356	74	5	was	be	AUX
ajird-1356	74	6	:	:	PUNCT
ajird-1356	74	7	•	•	NUM
ajird-1356	74	8	chlamydia	chlamydia	NOUN
ajird-1356	74	9	trachomatis	trachomatis	ADJ
ajird-1356	74	10	:	:	PUNCT
ajird-1356	74	11	prevalence	prevalence	NOUN
ajird-1356	74	12	of	of	ADP
ajird-1356	74	13	7.4	7.4	NUM
ajird-1356	74	14	%	%	NOUN
ajird-1356	74	15	(	(	PUNCT
ajird-1356	74	16	95	95	NUM
ajird-1356	74	17	%	%	NOUN
ajird-1356	74	18	ci	ci	NOUN
ajird-1356	74	19	:	:	PUNCT
ajird-1356	74	20	5.8–9.3	5.8–9.3	NUM
ajird-1356	74	21	%	%	NOUN
ajird-1356	74	22	)	)	PUNCT
ajird-1356	74	23	.	.	PUNCT
ajird-1356	75	1	•	•	NUM
ajird-1356	75	2	salmonella	salmonella	PROPN
ajird-1356	75	3	spp	spp	NOUN
ajird-1356	75	4	.	.	PUNCT
ajird-1356	75	5	:	:	PUNCT
ajird-1356	76	1	prevalence	prevalence	NOUN
ajird-1356	76	2	of	of	ADP
ajird-1356	76	3	12.3	12.3	NUM
ajird-1356	76	4	%	%	NOUN
ajird-1356	76	5	(	(	PUNCT
ajird-1356	76	6	95	95	NUM
ajird-1356	76	7	%	%	NOUN
ajird-1356	76	8	ci	ci	NOUN
ajird-1356	76	9	:	:	PUNCT
ajird-1356	76	10	9.0–16.5	9.0–16.5	NUM
ajird-1356	76	11	%	%	NOUN
ajird-1356	76	12	)	)	PUNCT
ajird-1356	76	13	.	.	PUNCT
ajird-1356	77	1	•	•	NUM
ajird-1356	77	2	shigella	shigella	PROPN
ajird-1356	77	3	spp	spp	PROPN
ajird-1356	77	4	.	.	PUNCT
ajird-1356	77	5	:	:	PUNCT
ajird-1356	78	1	prevalence	prevalence	NOUN
ajird-1356	78	2	of	of	ADP
ajird-1356	78	3	10.2	10.2	NUM
ajird-1356	78	4	%	%	NOUN
ajird-1356	78	5	(	(	PUNCT
ajird-1356	78	6	95	95	NUM
ajird-1356	78	7	%	%	NOUN
ajird-1356	78	8	ci	ci	NOUN
ajird-1356	78	9	:	:	PUNCT
ajird-1356	78	10	7.5–13.5	7.5–13.5	NUM
ajird-1356	78	11	%	%	NOUN
ajird-1356	78	12	)	)	PUNCT
ajird-1356	78	13	.	.	PUNCT
ajird-1356	79	1	•	•	NUM
ajird-1356	79	2	campylobacter	campylobacter	NOUN
ajird-1356	79	3	spp	spp	NOUN
ajird-1356	79	4	.	.	PUNCT
ajird-1356	79	5	:	:	PUNCT
ajird-1356	80	1	prevalence	prevalence	NOUN
ajird-1356	80	2	of	of	ADP
ajird-1356	80	3	14.1	14.1	NUM
ajird-1356	80	4	%	%	NOUN
ajird-1356	80	5	(	(	PUNCT
ajird-1356	80	6	95	95	NUM
ajird-1356	80	7	%	%	NOUN
ajird-1356	80	8	ci	ci	NOUN
ajird-1356	80	9	:	:	PUNCT
ajird-1356	80	10	11.0–17.8%).[7,8,9	11.0–17.8%).[7,8,9	NUM
ajird-1356	80	11	]	]	PUNCT
ajird-1356	80	12	heterogeneity	heterogeneity	NOUN
ajird-1356	80	13	was	be	AUX
ajird-1356	80	14	moderate	moderate	ADJ
ajird-1356	80	15	(	(	PUNCT
ajird-1356	80	16	i²	i²	NOUN
ajird-1356	80	17	=	=	PUNCT
ajird-1356	80	18	56	56	NUM
ajird-1356	80	19	%	%	NOUN
ajird-1356	80	20	)	)	PUNCT
ajird-1356	80	21	due	due	ADP
ajird-1356	80	22	to	to	ADP
ajird-1356	80	23	the	the	DET
ajird-1356	80	24	differences	difference	NOUN
ajird-1356	80	25	in	in	ADP
ajird-1356	80	26	the	the	DET
ajird-1356	80	27	study	study	NOUN
ajird-1356	80	28	populations	population	NOUN
ajird-1356	80	29	and	and	CCONJ
ajird-1356	80	30	geographical	geographical	ADJ
ajird-1356	80	31	variability	variability	NOUN
ajird-1356	80	32	.	.	PUNCT
ajird-1356	81	1	six	six	NUM
ajird-1356	81	2	studies	study	NOUN
ajird-1356	81	3	investigated	investigate	VERB
ajird-1356	81	4	the	the	DET
ajird-1356	81	5	association	association	NOUN
ajird-1356	81	6	between	between	ADP
ajird-1356	81	7	hla	hla	PROPN
ajird-1356	81	8	-	-	PUNCT
ajird-1356	81	9	b27	b27	PROPN
ajird-1356	81	10	and	and	CCONJ
ajird-1356	81	11	rea	rea	PROPN
ajird-1356	81	12	.	.	PUNCT
ajird-1356	82	1	the	the	DET
ajird-1356	82	2	pooled	pooled	ADJ
ajird-1356	82	3	estimate	estimate	NOUN
ajird-1356	82	4	for	for	ADP
ajird-1356	82	5	the	the	DET
ajird-1356	82	6	frequency	frequency	NOUN
ajird-1356	82	7	of	of	ADP
ajird-1356	82	8	hla	hla	PROPN
ajird-1356	82	9	-	-	PUNCT
ajird-1356	82	10	b27	b27	PROPN
ajird-1356	82	11	positivity	positivity	NOUN
ajird-1356	82	12	in	in	ADP
ajird-1356	82	13	rea	rea	PROPN
ajird-1356	82	14	patients	patient	NOUN
ajird-1356	82	15	was	be	AUX
ajird-1356	82	16	72	72	NUM
ajird-1356	82	17	%	%	NOUN
ajird-1356	82	18	(	(	PUNCT
ajird-1356	82	19	95	95	NUM
ajird-1356	82	20	%	%	NOUN
ajird-1356	82	21	ci	ci	NOUN
ajird-1356	82	22	:	:	PUNCT
ajird-1356	82	23	68–77	68–77	NUM
ajird-1356	82	24	%	%	NOUN
ajird-1356	82	25	)	)	PUNCT
ajird-1356	82	26	,	,	PUNCT
ajird-1356	82	27	compared	compare	VERB
ajird-1356	82	28	to	to	ADP
ajird-1356	82	29	8	8	NUM
ajird-1356	82	30	%	%	NOUN
ajird-1356	82	31	in	in	ADP
ajird-1356	82	32	the	the	DET
ajird-1356	82	33	general	general	ADJ
ajird-1356	82	34	population	population	NOUN
ajird-1356	82	35	.	.	PUNCT
ajird-1356	83	1	hla	hla	PROPN
ajird-1356	83	2	-	-	PUNCT
ajird-1356	83	3	b27	b27	PROPN
ajird-1356	83	4	positivity	positivity	NOUN
ajird-1356	83	5	was	be	AUX
ajird-1356	83	6	associated	associate	VERB
ajird-1356	83	7	with	with	ADP
ajird-1356	83	8	a	a	DET
ajird-1356	83	9	significantly	significantly	ADV
ajird-1356	83	10	increased	increase	VERB
ajird-1356	83	11	risk	risk	NOUN
ajird-1356	83	12	of	of	ADP
ajird-1356	83	13	chronicity	chronicity	NOUN
ajird-1356	83	14	or	or	CCONJ
ajird-1356	83	15	recurrence	recurrence	NOUN
ajird-1356	83	16	(	(	PUNCT
ajird-1356	83	17	rr	rr	NOUN
ajird-1356	83	18	=	=	SYM
ajird-1356	83	19	2.5	2.5	NUM
ajird-1356	83	20	,	,	PUNCT
ajird-1356	83	21	95	95	NUM
ajird-1356	83	22	%	%	NOUN
ajird-1356	83	23	ci	ci	NOUN
ajird-1356	83	24	:	:	PUNCT
ajird-1356	83	25	2.0–3.1	2.0–3.1	NUM
ajird-1356	83	26	)	)	PUNCT
ajird-1356	83	27	.	.	PUNCT
ajird-1356	84	1	heterogeneity	heterogeneity	NOUN
ajird-1356	84	2	across	across	ADP
ajird-1356	84	3	studies	study	NOUN
ajird-1356	84	4	was	be	AUX
ajird-1356	84	5	low	low	ADJ
ajird-1356	84	6	(	(	PUNCT
ajird-1356	84	7	i²	i²	NOUN
ajird-1356	84	8	=	=	SYM
ajird-1356	84	9	37%).[7,8,9	37%).[7,8,9	NOUN
ajird-1356	84	10	]	]	PUNCT
ajird-1356	84	11	.	.	PUNCT
ajird-1356	85	1	four	four	NUM
ajird-1356	85	2	studies	study	NOUN
ajird-1356	85	3	evaluated	evaluate	VERB
ajird-1356	85	4	the	the	DET
ajird-1356	85	5	efficacy	efficacy	NOUN
ajird-1356	85	6	of	of	ADP
ajird-1356	85	7	nsaids	nsaid	NOUN
ajird-1356	85	8	in	in	ADP
ajird-1356	85	9	the	the	DET
ajird-1356	85	10	acute	acute	ADJ
ajird-1356	85	11	management	management	NOUN
ajird-1356	85	12	of	of	ADP
ajird-1356	85	13	rea	rea	PROPN
ajird-1356	85	14	.	.	PROPN
ajird-1356	85	15	pooled	pool	VERB
ajird-1356	85	16	data	datum	NOUN
ajird-1356	85	17	showed	show	VERB
ajird-1356	85	18	that	that	SCONJ
ajird-1356	85	19	nsaids	nsaid	NOUN
ajird-1356	85	20	provided	provide	VERB
ajird-1356	85	21	symptomatic	symptomatic	ADJ
ajird-1356	85	22	relief	relief	NOUN
ajird-1356	85	23	in	in	ADP
ajird-1356	85	24	76	76	NUM
ajird-1356	85	25	%	%	NOUN
ajird-1356	85	26	(	(	PUNCT
ajird-1356	85	27	95	95	NUM
ajird-1356	85	28	%	%	NOUN
ajird-1356	85	29	ci	ci	NOUN
ajird-1356	85	30	:	:	PUNCT
ajird-1356	85	31	71–82	71–82	NUM
ajird-1356	85	32	%	%	NOUN
ajird-1356	85	33	)	)	PUNCT
ajird-1356	85	34	of	of	ADP
ajird-1356	85	35	patients	patient	NOUN
ajird-1356	85	36	,	,	PUNCT
ajird-1356	85	37	although	although	SCONJ
ajird-1356	85	38	40	40	NUM
ajird-1356	85	39	%	%	NOUN
ajird-1356	85	40	(	(	PUNCT
ajird-1356	85	41	95	95	NUM
ajird-1356	85	42	%	%	NOUN
ajird-1356	85	43	ci	ci	NOUN
ajird-1356	85	44	:	:	PUNCT
ajird-1356	85	45	34–47	34–47	NUM
ajird-1356	85	46	%	%	NOUN
ajird-1356	85	47	)	)	PUNCT
ajird-1356	85	48	experienced	experienced	ADJ
ajird-1356	85	49	recurrence	recurrence	NOUN
ajird-1356	85	50	upon	upon	SCONJ
ajird-1356	85	51	discontinuation	discontinuation	NOUN
ajird-1356	85	52	of	of	ADP
ajird-1356	85	53	nsaid	nsaid	ADJ
ajird-1356	85	54	treatment	treatment	NOUN
ajird-1356	85	55	.	.	PUNCT
ajird-1356	86	1	the	the	DET
ajird-1356	86	2	effectiveness	effectiveness	NOUN
ajird-1356	86	3	of	of	ADP
ajird-1356	86	4	nsaids	nsaid	NOUN
ajird-1356	86	5	in	in	ADP
ajird-1356	86	6	preventing	prevent	VERB
ajird-1356	86	7	chronicity	chronicity	NOUN
ajird-1356	86	8	was	be	AUX
ajird-1356	86	9	limited	limit	VERB
ajird-1356	86	10	,	,	PUNCT
ajird-1356	86	11	and	and	CCONJ
ajird-1356	86	12	recurrence	recurrence	NOUN
ajird-1356	86	13	rates	rate	NOUN
ajird-1356	86	14	were	be	AUX
ajird-1356	86	15	higher	high	ADJ
ajird-1356	86	16	in	in	ADP
ajird-1356	86	17	patients	patient	NOUN
ajird-1356	86	18	with	with	ADP
ajird-1356	86	19	hla	hla	PROPN
ajird-1356	86	20	-	-	PUNCT
ajird-1356	86	21	b27	b27	PROPN
ajird-1356	86	22	positivity	positivity	NOUN
ajird-1356	86	23	.	.	PUNCT
ajird-1356	87	1	[	[	X
ajird-1356	87	2	9	9	NUM
ajird-1356	87	3	]	]	PUNCT
ajird-1356	87	4	.	.	PUNCT
ajird-1356	88	1	five	five	NUM
ajird-1356	88	2	studies	study	NOUN
ajird-1356	88	3	assessed	assess	VERB
ajird-1356	88	4	the	the	DET
ajird-1356	88	5	role	role	NOUN
ajird-1356	88	6	of	of	ADP
ajird-1356	88	7	dmards	dmard	NOUN
ajird-1356	88	8	,	,	PUNCT
ajird-1356	88	9	particularly	particularly	ADV
ajird-1356	88	10	methotrexate	methotrexate	NOUN
ajird-1356	88	11	and	and	CCONJ
ajird-1356	88	12	sulfasalazine	sulfasalazine	NOUN
ajird-1356	88	13	,	,	PUNCT
ajird-1356	88	14	in	in	ADP
ajird-1356	88	15	chronic	chronic	ADJ
ajird-1356	88	16	or	or	CCONJ
ajird-1356	88	17	severe	severe	ADJ
ajird-1356	88	18	rea	rea	PROPN
ajird-1356	88	19	.	.	PROPN
ajird-1356	89	1	pooled	pool	VERB
ajird-1356	89	2	results	result	NOUN
ajird-1356	89	3	showed	show	VERB
ajird-1356	89	4	a	a	DET
ajird-1356	89	5	60	60	NUM
ajird-1356	89	6	%	%	NOUN
ajird-1356	89	7	remission	remission	NOUN
ajird-1356	89	8	rate	rate	NOUN
ajird-1356	89	9	(	(	PUNCT
ajird-1356	89	10	95	95	NUM
ajird-1356	89	11	%	%	NOUN
ajird-1356	89	12	ci	ci	NOUN
ajird-1356	89	13	:	:	PUNCT
ajird-1356	89	14	53–67	53–67	NUM
ajird-1356	89	15	%	%	NOUN
ajird-1356	89	16	)	)	PUNCT
ajird-1356	89	17	after	after	ADP
ajird-1356	89	18	6	6	NUM
ajird-1356	89	19	months	month	NOUN
ajird-1356	89	20	of	of	ADP
ajird-1356	89	21	dmard	dmard	NOUN
ajird-1356	89	22	therapy	therapy	NOUN
ajird-1356	89	23	.	.	PUNCT
ajird-1356	90	1	dmards	dmard	NOUN
ajird-1356	90	2	were	be	AUX
ajird-1356	90	3	associated	associate	VERB
ajird-1356	90	4	with	with	ADP
ajird-1356	90	5	a	a	DET
ajird-1356	90	6	relative	relative	ADJ
ajird-1356	90	7	risk	risk	NOUN
ajird-1356	90	8	reduction	reduction	NOUN
ajird-1356	90	9	for	for	ADP
ajird-1356	90	10	long	long	ADJ
ajird-1356	90	11	-	-	PUNCT
ajird-1356	90	12	term	term	NOUN
ajird-1356	90	13	joint	joint	ADJ
ajird-1356	90	14	damage	damage	NOUN
ajird-1356	90	15	(	(	PUNCT
ajird-1356	90	16	rr	rr	NOUN
ajird-1356	90	17	=	=	SYM
ajird-1356	90	18	0.68	0.68	NUM
ajird-1356	90	19	,	,	PUNCT
ajird-1356	90	20	95	95	NUM
ajird-1356	90	21	%	%	NOUN
ajird-1356	90	22	ci	ci	NOUN
ajird-1356	90	23	:	:	PUNCT
ajird-1356	90	24	0.56–0.83	0.56–0.83	NUM
ajird-1356	90	25	)	)	PUNCT
ajird-1356	90	26	compared	compare	VERB
ajird-1356	90	27	to	to	ADP
ajird-1356	90	28	nsaids	nsaid	NOUN
ajird-1356	90	29	alone	alone	ADV
ajird-1356	90	30	.	.	PUNCT
ajird-1356	91	1	heterogeneity	heterogeneity	PROPN
ajird-1356	91	2	was	be	AUX
ajird-1356	91	3	moderate	moderate	ADJ
ajird-1356	91	4	(	(	PUNCT
ajird-1356	91	5	i²	i²	NOUN
ajird-1356	91	6	=	=	PUNCT
ajird-1356	91	7	45%).[7,8,9,10	45%).[7,8,9,10	X
ajird-1356	91	8	]	]	PUNCT
ajird-1356	91	9	.	.	PUNCT
ajird-1356	92	1	seven	seven	NUM
ajird-1356	92	2	studies	study	NOUN
ajird-1356	92	3	evaluated	evaluate	VERB
ajird-1356	92	4	biologic	biologic	NOUN
ajird-1356	92	5	agents	agent	NOUN
ajird-1356	92	6	,	,	PUNCT
ajird-1356	92	7	mainly	mainly	ADV
ajird-1356	92	8	tnf	tnf	PROPN
ajird-1356	92	9	-	-	PUNCT
ajird-1356	92	10	α	α	NOUN
ajird-1356	92	11	inhibitors	inhibitor	NOUN
ajird-1356	92	12	(	(	PUNCT
ajird-1356	92	13	etanercept	etanercept	NOUN
ajird-1356	92	14	,	,	PUNCT
ajird-1356	92	15	infliximab	infliximab	NOUN
ajird-1356	92	16	)	)	PUNCT
ajird-1356	92	17	,	,	PUNCT
ajird-1356	92	18	in	in	ADP
ajird-1356	92	19	patients	patient	NOUN
ajird-1356	92	20	with	with	ADP
ajird-1356	92	21	refractory	refractory	PROPN
ajird-1356	92	22	rea	rea	PROPN
ajird-1356	92	23	.	.	PUNCT
ajird-1356	93	1	the	the	DET
ajird-1356	93	2	response	response	NOUN
ajird-1356	93	3	rate	rate	NOUN
ajird-1356	93	4	for	for	ADP
ajird-1356	93	5	biologic	biologic	NOUN
ajird-1356	93	6	therapy	therapy	NOUN
ajird-1356	93	7	was	be	AUX
ajird-1356	93	8	68	68	NUM
ajird-1356	93	9	%	%	NOUN
ajird-1356	93	10	(	(	PUNCT
ajird-1356	93	11	95	95	NUM
ajird-1356	93	12	%	%	NOUN
ajird-1356	93	13	ci	ci	NOUN
ajird-1356	93	14	:	:	PUNCT
ajird-1356	93	15	61–75	61–75	NUM
ajird-1356	93	16	%	%	NOUN
ajird-1356	93	17	)	)	PUNCT
ajird-1356	93	18	,	,	PUNCT
ajird-1356	93	19	with	with	ADP
ajird-1356	93	20	a	a	DET
ajird-1356	93	21	significant	significant	ADJ
ajird-1356	93	22	reduction	reduction	NOUN
ajird-1356	93	23	in	in	ADP
ajird-1356	93	24	inflammatory	inflammatory	ADJ
ajird-1356	93	25	markers	marker	NOUN
ajird-1356	93	26	(	(	PUNCT
ajird-1356	93	27	crp	crp	PROPN
ajird-1356	93	28	and	and	CCONJ
ajird-1356	93	29	esr	esr	NOUN
ajird-1356	93	30	)	)	PUNCT
ajird-1356	93	31	.	.	PUNCT
ajird-1356	94	1	biologics	biologic	NOUN
ajird-1356	94	2	were	be	AUX
ajird-1356	94	3	more	more	ADV
ajird-1356	94	4	effective	effective	ADJ
ajird-1356	94	5	in	in	ADP
ajird-1356	94	6	hla	hla	PROPN
ajird-1356	94	7	-	-	PUNCT
ajird-1356	94	8	b27	b27	PROPN
ajird-1356	94	9	-	-	PUNCT
ajird-1356	94	10	positive	positive	ADJ
ajird-1356	94	11	patients	patient	NOUN
ajird-1356	94	12	compared	compare	VERB
ajird-1356	94	13	to	to	ADP
ajird-1356	94	14	hla	hla	NOUN
ajird-1356	94	15	-	-	PUNCT
ajird-1356	94	16	b27	b27	PROPN
ajird-1356	94	17	-	-	PUNCT
ajird-1356	94	18	negative	negative	ADJ
ajird-1356	94	19	patients	patient	NOUN
ajird-1356	94	20	(	(	PUNCT
ajird-1356	94	21	or	or	CCONJ
ajird-1356	94	22	=	=	SYM
ajird-1356	94	23	2.1	2.1	NUM
ajird-1356	94	24	,	,	PUNCT
ajird-1356	94	25	95	95	NUM
ajird-1356	94	26	%	%	NOUN
ajird-1356	94	27	ci	ci	NOUN
ajird-1356	94	28	:	:	PUNCT
ajird-1356	94	29	1.4–3.2	1.4–3.2	NUM
ajird-1356	94	30	)	)	PUNCT
ajird-1356	94	31	.	.	PUNCT
ajird-1356	95	1	heterogeneity	heterogeneity	NOUN
ajird-1356	95	2	was	be	AUX
ajird-1356	95	3	substantial	substantial	ADJ
ajird-1356	95	4	(	(	PUNCT
ajird-1356	95	5	i²	i²	NOUN
ajird-1356	95	6	=	=	NOUN
ajird-1356	95	7	61	61	NUM
ajird-1356	95	8	%	%	NOUN
ajird-1356	95	9	)	)	PUNCT
ajird-1356	95	10	,	,	PUNCT
ajird-1356	95	11	likely	likely	ADJ
ajird-1356	95	12	due	due	ADP
ajird-1356	95	13	to	to	ADP
ajird-1356	95	14	varying	vary	VERB
ajird-1356	95	15	biologic	biologic	NOUN
ajird-1356	95	16	agents	agent	NOUN
ajird-1356	95	17	and	and	CCONJ
ajird-1356	95	18	patient	patient	NOUN
ajird-1356	95	19	characteristics.[10	characteristics.[10	PROPN
ajird-1356	95	20	]	]	PUNCT
ajird-1356	95	21	american	american	PROPN
ajird-1356	95	22	journal	journal	PROPN
ajird-1356	95	23	of	of	ADP
ajird-1356	95	24	interdisciplinary	interdisciplinary	ADJ
ajird-1356	95	25	research	research	NOUN
ajird-1356	95	26	and	and	CCONJ
ajird-1356	95	27	development	development	NOUN
ajird-1356	95	28	issn	issn	PROPN
ajird-1356	95	29	online	online	NOUN
ajird-1356	95	30	:	:	PUNCT
ajird-1356	95	31	2771	2771	NUM
ajird-1356	95	32	-	-	SYM
ajird-1356	95	33	8948	8948	NUM
ajird-1356	95	34	website	website	NOUN
ajird-1356	95	35	:	:	PUNCT
ajird-1356	95	36	www.ajird.journalspark.org	www.ajird.journalspark.org	ADJ
ajird-1356	95	37	volume	volume	NOUN
ajird-1356	95	38	34	34	NUM
ajird-1356	95	39	,	,	PUNCT
ajird-1356	95	40	november	november	PROPN
ajird-1356	95	41	2024	2024	NUM
ajird-1356	95	42	35	35	NUM
ajird-1356	96	1	|	|	ADV
ajird-1356	96	2	p	p	NOUN
ajird-1356	96	3	a	a	DET
ajird-1356	96	4	g	g	NOUN
ajird-1356	96	5	e	e	NOUN
ajird-1356	96	6	discussion	discussion	NOUN
ajird-1356	96	7	.	.	PUNCT
ajird-1356	97	1	diagnosis	diagnosis	NOUN
ajird-1356	97	2	and	and	CCONJ
ajird-1356	97	3	management	management	NOUN
ajird-1356	97	4	recognition	recognition	NOUN
ajird-1356	97	5	of	of	ADP
ajird-1356	97	6	the	the	DET
ajird-1356	97	7	rheumatological	rheumatological	ADJ
ajird-1356	97	8	clinical	clinical	ADJ
ajird-1356	97	9	picture	picture	NOUN
ajird-1356	97	10	evidence	evidence	NOUN
ajird-1356	97	11	of	of	ADP
ajird-1356	97	12	genitourinary	genitourinary	ADJ
ajird-1356	97	13	infection	infection	NOUN
ajird-1356	97	14	and	and	CCONJ
ajird-1356	97	15	identification	identification	NOUN
ajird-1356	97	16	of	of	ADP
ajird-1356	97	17	genital	genital	ADJ
ajird-1356	97	18	pathogens	pathogen	NOUN
ajird-1356	97	19	research	research	NOUN
ajird-1356	97	20	on	on	ADP
ajird-1356	97	21	the	the	DET
ajird-1356	97	22	specificity	specificity	NOUN
ajird-1356	97	23	and	and	CCONJ
ajird-1356	97	24	activity	activity	NOUN
ajird-1356	97	25	of	of	ADP
ajird-1356	97	26	arthritis	arthritis	NOUN
ajird-1356	97	27	management	management	NOUN
ajird-1356	97	28	information	information	NOUN
ajird-1356	97	29	,	,	PUNCT
ajird-1356	97	30	education	education	NOUN
ajird-1356	97	31	,	,	PUNCT
ajird-1356	97	32	care	care	NOUN
ajird-1356	97	33	and	and	CCONJ
ajird-1356	97	34	testing	testing	NOUN
ajird-1356	97	35	of	of	ADP
ajird-1356	97	36	partners	partner	NOUN
ajird-1356	97	37	and	and	CCONJ
ajird-1356	97	38	other	other	ADJ
ajird-1356	97	39	stis	stis	PROPN
ajird-1356	97	40	further	further	ADJ
ajird-1356	97	41	investigations	investigation	NOUN
ajird-1356	97	42	:	:	PUNCT
ajird-1356	97	43	systematically	systematically	ADV
ajird-1356	97	44	:	:	PUNCT
ajird-1356	97	45	synovial	synovial	ADJ
ajird-1356	97	46	fluid	fluid	ADJ
ajird-1356	97	47	analysis	analysis	NOUN
ajird-1356	97	48	,	,	PUNCT
ajird-1356	97	49	screening	screen	VERB
ajird-1356	97	50	for	for	ADP
ajird-1356	97	51	other	other	ADJ
ajird-1356	97	52	stis	stis	NOUN
ajird-1356	97	53	,	,	PUNCT
ajird-1356	97	54	biological	biological	ADJ
ajird-1356	97	55	markers	marker	NOUN
ajird-1356	97	56	of	of	ADP
ajird-1356	97	57	inflammation	inflammation	NOUN
ajird-1356	97	58	,	,	PUNCT
ajird-1356	97	59	blood	blood	NOUN
ajird-1356	97	60	count	count	NOUN
ajird-1356	97	61	,	,	PUNCT
ajird-1356	97	62	urinalysis	urinalysis	NOUN
ajird-1356	97	63	.	.	PUNCT
ajird-1356	98	1	according	accord	VERB
ajird-1356	98	2	to	to	ADP
ajird-1356	98	3	the	the	DET
ajird-1356	98	4	case	case	NOUN
ajird-1356	98	5	:	:	PUNCT
ajird-1356	98	6	imaging	imaging	NOUN
ajird-1356	98	7	,	,	PUNCT
ajird-1356	98	8	hla	hla	PROPN
ajird-1356	98	9	-	-	PUNCT
ajird-1356	98	10	b27	b27	PROPN
ajird-1356	98	11	,	,	PUNCT
ajird-1356	98	12	electrocardiogram	electrocardiogram	NOUN
ajird-1356	98	13	,	,	PUNCT
ajird-1356	98	14	ophthalmologic	ophthalmologic	ADJ
ajird-1356	98	15	consultation	consultation	NOUN
ajird-1356	98	16	,	,	PUNCT
ajird-1356	98	17	exclusion	exclusion	NOUN
ajird-1356	98	18	tests	test	NOUN
ajird-1356	98	19	for	for	ADP
ajird-1356	98	20	other	other	ADJ
ajird-1356	98	21	rheumatic	rheumatic	ADJ
ajird-1356	98	22	diseases	disease	NOUN
ajird-1356	98	23	,	,	PUNCT
ajird-1356	98	24	blood	blood	NOUN
ajird-1356	98	25	cultures	culture	NOUN
ajird-1356	98	26	,	,	PUNCT
ajird-1356	98	27	stool	stool	NOUN
ajird-1356	98	28	cultures	culture	NOUN
ajird-1356	98	29	,	,	PUNCT
ajird-1356	98	30	echocardiography	echocardiography	NOUN
ajird-1356	98	31	.	.	PUNCT
ajird-1356	99	1	treatment	treatment	NOUN
ajird-1356	99	2	:	:	PUNCT
ajird-1356	99	3	arthritis	arthritis	NOUN
ajird-1356	99	4	,	,	PUNCT
ajird-1356	99	5	enthesitis	enthesitis	PROPN
ajird-1356	99	6	:	:	PUNCT
ajird-1356	99	7	first	first	ADJ
ajird-1356	99	8	line	line	NOUN
ajird-1356	99	9	:	:	PUNCT
ajird-1356	99	10	rest	rest	NOUN
ajird-1356	99	11	,	,	PUNCT
ajird-1356	99	12	physical	physical	ADJ
ajird-1356	99	13	treatment	treatment	NOUN
ajird-1356	99	14	(	(	PUNCT
ajird-1356	99	15	cryotherapy	cryotherapy	NOUN
ajird-1356	99	16	)	)	PUNCT
ajird-1356	99	17	nsaids	nsaid	VERB
ajird-1356	99	18	intra	intra	ADJ
ajird-1356	99	19	-	-	ADJ
ajird-1356	99	20	articular	articular	ADJ
ajird-1356	99	21	corticosteroid	corticosteroid	ADJ
ajird-1356	99	22	therapy	therapy	NOUN
ajird-1356	99	23	/	/	SYM
ajird-1356	99	24	enthesis	enthesis	NOUN
ajird-1356	99	25	second	second	ADJ
ajird-1356	99	26	line	line	NOUN
ajird-1356	99	27	(	(	PUNCT
ajird-1356	99	28	moderate	moderate	ADJ
ajird-1356	99	29	to	to	ADP
ajird-1356	99	30	severe	severe	ADJ
ajird-1356	99	31	arthritis	arthritis	NOUN
ajird-1356	99	32	,	,	PUNCT
ajird-1356	99	33	first	first	ADJ
ajird-1356	99	34	line	line	NOUN
ajird-1356	99	35	failure	failure	NOUN
ajird-1356	99	36	)	)	PUNCT
ajird-1356	100	1	systemic	systemic	ADJ
ajird-1356	100	2	corticosteroids	corticosteroid	NOUN
ajird-1356	100	3	dmards	dmard	NOUN
ajird-1356	100	4	(	(	PUNCT
ajird-1356	100	5	sulfasalazine	sulfasalazine	NOUN
ajird-1356	100	6	,	,	PUNCT
ajird-1356	100	7	methotrexate	methotrexate	NOUN
ajird-1356	100	8	)	)	PUNCT
ajird-1356	100	9	biological	biological	ADJ
ajird-1356	100	10	anti	anti	ADJ
ajird-1356	100	11	-	-	ADJ
ajird-1356	100	12	tnf	tnf	ADJ
ajird-1356	100	13	agents	agent	NOUN
ajird-1356	100	14	(	(	PUNCT
ajird-1356	100	15	place	place	NOUN
ajird-1356	100	16	to	to	PART
ajird-1356	100	17	be	be	AUX
ajird-1356	100	18	specified	specify	VERB
ajird-1356	100	19	)	)	PUNCT
ajird-1356	100	20	antibiotics	antibiotic	NOUN
ajird-1356	100	21	:	:	PUNCT
ajird-1356	100	22	standard	standard	ADJ
ajird-1356	100	23	treatment	treatment	NOUN
ajird-1356	100	24	of	of	ADP
ajird-1356	100	25	active	active	ADJ
ajird-1356	100	26	infection	infection	NOUN
ajird-1356	100	27	;	;	PUNCT
ajird-1356	100	28	prolonged	prolong	VERB
ajird-1356	100	29	antibiotic	antibiotic	ADJ
ajird-1356	100	30	treatment	treatment	NOUN
ajird-1356	100	31	not	not	PART
ajird-1356	100	32	established	establish	VERB
ajird-1356	100	33	cutaneous	cutaneous	ADJ
ajird-1356	100	34	,	,	PUNCT
ajird-1356	100	35	mucosal	mucosal	ADJ
ajird-1356	100	36	and	and	CCONJ
ajird-1356	100	37	ophthalmological	ophthalmological	ADJ
ajird-1356	100	38	damage	damage	NOUN
ajird-1356	100	39	:	:	PUNCT
ajird-1356	100	40	specific	specific	ADJ
ajird-1356	100	41	dermatological	dermatological	ADJ
ajird-1356	100	42	and	and	CCONJ
ajird-1356	100	43	ophthalmological	ophthalmological	ADJ
ajird-1356	100	44	treatment.[10,11	treatment.[10,11	NOUN
ajird-1356	100	45	]	]	PUNCT
ajird-1356	100	46	.	.	PUNCT
ajird-1356	101	1	discussion	discussion	NOUN
ajird-1356	101	2	and	and	CCONJ
ajird-1356	101	3	research	research	NOUN
ajird-1356	101	4	gaps	gap	NOUN
ajird-1356	101	5	in	in	ADP
ajird-1356	101	6	reactive	reactive	ADJ
ajird-1356	101	7	arthritis	arthritis	NOUN
ajird-1356	101	8	reactive	reactive	NOUN
ajird-1356	101	9	arthritis	arthritis	NOUN
ajird-1356	101	10	(	(	PUNCT
ajird-1356	101	11	rea	rea	PROPN
ajird-1356	101	12	)	)	PUNCT
ajird-1356	101	13	is	be	AUX
ajird-1356	101	14	a	a	DET
ajird-1356	101	15	clinically	clinically	ADV
ajird-1356	101	16	heterogeneous	heterogeneous	ADJ
ajird-1356	101	17	disease	disease	NOUN
ajird-1356	101	18	that	that	PRON
ajird-1356	101	19	poses	pose	VERB
ajird-1356	101	20	significant	significant	ADJ
ajird-1356	101	21	challenges	challenge	NOUN
ajird-1356	101	22	in	in	ADP
ajird-1356	101	23	both	both	DET
ajird-1356	101	24	diagnosis	diagnosis	NOUN
ajird-1356	101	25	and	and	CCONJ
ajird-1356	101	26	management	management	NOUN
ajird-1356	101	27	.	.	PUNCT
ajird-1356	102	1	this	this	DET
ajird-1356	102	2	meta	meta	ADJ
ajird-1356	102	3	-	-	PUNCT
ajird-1356	102	4	analysis	analysis	NOUN
ajird-1356	102	5	consolidates	consolidate	VERB
ajird-1356	102	6	current	current	ADJ
ajird-1356	102	7	knowledge	knowledge	NOUN
ajird-1356	102	8	on	on	ADP
ajird-1356	102	9	its	its	PRON
ajird-1356	102	10	prevalence	prevalence	NOUN
ajird-1356	102	11	,	,	PUNCT
ajird-1356	102	12	risk	risk	NOUN
ajird-1356	102	13	factors	factor	NOUN
ajird-1356	102	14	,	,	PUNCT
ajird-1356	102	15	and	and	CCONJ
ajird-1356	102	16	treatment	treatment	NOUN
ajird-1356	102	17	efficacy	efficacy	NOUN
ajird-1356	102	18	,	,	PUNCT
ajird-1356	102	19	but	but	CCONJ
ajird-1356	102	20	it	it	PRON
ajird-1356	102	21	also	also	ADV
ajird-1356	102	22	highlights	highlight	VERB
ajird-1356	102	23	several	several	ADJ
ajird-1356	102	24	gaps	gap	NOUN
ajird-1356	102	25	in	in	ADP
ajird-1356	102	26	the	the	DET
ajird-1356	102	27	literature	literature	NOUN
ajird-1356	102	28	that	that	PRON
ajird-1356	102	29	warrant	warrant	VERB
ajird-1356	102	30	further	further	ADJ
ajird-1356	102	31	investigation	investigation	NOUN
ajird-1356	102	32	.	.	PUNCT
ajird-1356	103	1	these	these	DET
ajird-1356	103	2	gaps	gap	NOUN
ajird-1356	103	3	are	be	AUX
ajird-1356	103	4	particularly	particularly	ADV
ajird-1356	103	5	crucial	crucial	ADJ
ajird-1356	103	6	for	for	ADP
ajird-1356	103	7	improving	improve	VERB
ajird-1356	103	8	clinical	clinical	ADJ
ajird-1356	103	9	outcomes	outcome	NOUN
ajird-1356	103	10	and	and	CCONJ
ajird-1356	103	11	optimizing	optimize	VERB
ajird-1356	103	12	treatment	treatment	NOUN
ajird-1356	103	13	strategies	strategy	NOUN
ajird-1356	103	14	.	.	PUNCT
ajird-1356	104	1	genetic	genetic	ADJ
ajird-1356	104	2	predisposition	predisposition	NOUN
ajird-1356	104	3	beyond	beyond	ADP
ajird-1356	104	4	hla	hla	PROPN
ajird-1356	104	5	-	-	PUNCT
ajird-1356	104	6	b27	b27	PROPN
ajird-1356	104	7	.	.	PUNCT
ajird-1356	105	1	while	while	SCONJ
ajird-1356	105	2	hla	hla	NOUN
ajird-1356	105	3	-	-	PUNCT
ajird-1356	105	4	b27	b27	PROPN
ajird-1356	105	5	is	be	AUX
ajird-1356	105	6	a	a	DET
ajird-1356	105	7	well	well	ADV
ajird-1356	105	8	-	-	PUNCT
ajird-1356	105	9	established	establish	VERB
ajird-1356	105	10	genetic	genetic	ADJ
ajird-1356	105	11	marker	marker	NOUN
ajird-1356	105	12	associated	associate	VERB
ajird-1356	105	13	with	with	ADP
ajird-1356	105	14	rea	rea	PROPN
ajird-1356	105	15	,	,	PUNCT
ajird-1356	105	16	its	its	PRON
ajird-1356	105	17	presence	presence	NOUN
ajird-1356	105	18	does	do	AUX
ajird-1356	105	19	not	not	PART
ajird-1356	105	20	explain	explain	VERB
ajird-1356	105	21	the	the	DET
ajird-1356	105	22	entire	entire	ADJ
ajird-1356	105	23	disease	disease	NOUN
ajird-1356	105	24	spectrum	spectrum	NOUN
ajird-1356	105	25	.	.	PUNCT
ajird-1356	106	1	approximately	approximately	ADV
ajird-1356	106	2	20	20	NUM
ajird-1356	106	3	-	-	SYM
ajird-1356	106	4	30	30	NUM
ajird-1356	106	5	%	%	NOUN
ajird-1356	106	6	of	of	ADP
ajird-1356	106	7	patients	patient	NOUN
ajird-1356	106	8	with	with	ADP
ajird-1356	106	9	rea	rea	PROPN
ajird-1356	106	10	are	be	AUX
ajird-1356	106	11	hla	hla	NOUN
ajird-1356	106	12	-	-	PUNCT
ajird-1356	106	13	b27	b27	NOUN
ajird-1356	106	14	negative	negative	ADJ
ajird-1356	106	15	,	,	PUNCT
ajird-1356	106	16	and	and	CCONJ
ajird-1356	106	17	these	these	DET
ajird-1356	106	18	patients	patient	NOUN
ajird-1356	106	19	may	may	AUX
ajird-1356	106	20	exhibit	exhibit	VERB
ajird-1356	106	21	different	different	ADJ
ajird-1356	106	22	disease	disease	NOUN
ajird-1356	106	23	courses	course	NOUN
ajird-1356	106	24	and	and	CCONJ
ajird-1356	106	25	responses	response	NOUN
ajird-1356	106	26	to	to	ADP
ajird-1356	106	27	treatment	treatment	NOUN
ajird-1356	106	28	is	be	AUX
ajird-1356	106	29	needed	need	VERB
ajird-1356	106	30	to	to	PART
ajird-1356	106	31	explore	explore	VERB
ajird-1356	106	32	the	the	DET
ajird-1356	106	33	genetic	genetic	ADJ
ajird-1356	106	34	factors	factor	NOUN
ajird-1356	106	35	that	that	PRON
ajird-1356	106	36	predispose	predispose	VERB
ajird-1356	106	37	individuals	individual	NOUN
ajird-1356	106	38	to	to	PART
ajird-1356	106	39	rea	rea	VERB
ajird-1356	106	40	in	in	ADP
ajird-1356	106	41	the	the	DET
ajird-1356	106	42	absence	absence	NOUN
ajird-1356	106	43	of	of	ADP
ajird-1356	106	44	hla	hla	PROPN
ajird-1356	106	45	-	-	PUNCT
ajird-1356	106	46	b27	b27	PROPN
ajird-1356	106	47	,	,	PUNCT
ajird-1356	106	48	american	american	ADJ
ajird-1356	106	49	journal	journal	PROPN
ajird-1356	106	50	of	of	ADP
ajird-1356	106	51	interdisciplinary	interdisciplinary	ADJ
ajird-1356	106	52	research	research	NOUN
ajird-1356	106	53	and	and	CCONJ
ajird-1356	106	54	development	development	NOUN
ajird-1356	106	55	issn	issn	PROPN
ajird-1356	106	56	online	online	NOUN
ajird-1356	106	57	:	:	PUNCT
ajird-1356	106	58	2771	2771	NUM
ajird-1356	106	59	-	-	SYM
ajird-1356	106	60	8948	8948	NUM
ajird-1356	106	61	website	website	NOUN
ajird-1356	106	62	:	:	PUNCT
ajird-1356	106	63	www.ajird.journalspark.org	www.ajird.journalspark.org	ADJ
ajird-1356	106	64	volume	volume	NOUN
ajird-1356	106	65	34	34	NUM
ajird-1356	106	66	,	,	PUNCT
ajird-1356	106	67	november	november	PROPN
ajird-1356	106	68	2024	2024	NUM
ajird-1356	106	69	36	36	NUM
ajird-1356	106	70	|	|	ADV
ajird-1356	106	71	p	p	ADP
ajird-1356	106	72	a	a	DET
ajird-1356	106	73	g	g	NOUN
ajird-1356	106	74	e	e	NOUN
ajird-1356	106	75	potentially	potentially	ADV
ajird-1356	106	76	involving	involve	VERB
ajird-1356	106	77	genome	genome	NOUN
ajird-1356	106	78	-	-	PUNCT
ajird-1356	106	79	wide	wide	ADJ
ajird-1356	106	80	association	association	NOUN
ajird-1356	106	81	studies	study	NOUN
ajird-1356	106	82	(	(	PUNCT
ajird-1356	106	83	gwas	gwas	PROPN
ajird-1356	106	84	)	)	PUNCT
ajird-1356	106	85	to	to	PART
ajird-1356	106	86	identify	identify	VERB
ajird-1356	106	87	novel	novel	ADJ
ajird-1356	106	88	susceptibility	susceptibility	NOUN
ajird-1356	106	89	loci.[13,14	loci.[13,14	ADP
ajird-1356	106	90	]	]	PUNCT
ajird-1356	106	91	pathogen	pathogen	NOUN
ajird-1356	106	92	-	-	PUNCT
ajird-1356	106	93	specific	specific	ADJ
ajird-1356	106	94	disease	disease	NOUN
ajird-1356	106	95	mechanisms	mechanism	NOUN
ajird-1356	106	96	.	.	PUNCT
ajird-1356	107	1	reactive	reactive	ADJ
ajird-1356	107	2	arthritis	arthritis	NOUN
ajird-1356	107	3	is	be	AUX
ajird-1356	107	4	commonly	commonly	ADV
ajird-1356	107	5	triggered	trigger	VERB
ajird-1356	107	6	by	by	ADP
ajird-1356	107	7	infections	infection	NOUN
ajird-1356	107	8	with	with	ADP
ajird-1356	107	9	chlamydia	chlamydia	NOUN
ajird-1356	107	10	trachomatis	trachomatis	ADJ
ajird-1356	107	11	,	,	PUNCT
ajird-1356	107	12	salmonella	salmonella	NOUN
ajird-1356	107	13	,	,	PUNCT
ajird-1356	107	14	shigella	shigella	NOUN
ajird-1356	107	15	,	,	PUNCT
ajird-1356	107	16	campylobacter	campylobacter	NOUN
ajird-1356	107	17	,	,	PUNCT
ajird-1356	107	18	and	and	CCONJ
ajird-1356	107	19	yersinia	yersinia	NOUN
ajird-1356	107	20	.	.	PUNCT
ajird-1356	108	1	however	however	ADV
ajird-1356	108	2	,	,	PUNCT
ajird-1356	108	3	the	the	DET
ajird-1356	108	4	exact	exact	ADJ
ajird-1356	108	5	mechanisms	mechanism	NOUN
ajird-1356	108	6	by	by	ADP
ajird-1356	108	7	which	which	PRON
ajird-1356	108	8	these	these	DET
ajird-1356	108	9	pathogens	pathogen	NOUN
ajird-1356	108	10	trigger	trigger	VERB
ajird-1356	108	11	an	an	DET
ajird-1356	108	12	aberrant	aberrant	ADJ
ajird-1356	108	13	immune	immune	ADJ
ajird-1356	108	14	response	response	NOUN
ajird-1356	108	15	remain	remain	AUX
ajird-1356	108	16	poorly	poorly	ADV
ajird-1356	108	17	understood	understand	VERB
ajird-1356	108	18	.	.	PUNCT
ajird-1356	109	1	emerging	emerge	VERB
ajird-1356	109	2	evidence	evidence	NOUN
ajird-1356	109	3	suggests	suggest	VERB
ajird-1356	109	4	that	that	SCONJ
ajird-1356	109	5	molecular	molecular	ADJ
ajird-1356	109	6	mimicry	mimicry	NOUN
ajird-1356	109	7	,	,	PUNCT
ajird-1356	109	8	persistent	persistent	ADJ
ajird-1356	109	9	infection	infection	NOUN
ajird-1356	109	10	,	,	PUNCT
ajird-1356	109	11	and	and	CCONJ
ajird-1356	109	12	altered	alter	VERB
ajird-1356	109	13	gut	gut	NOUN
ajird-1356	109	14	microbiota	microbiota	NOUN
ajird-1356	109	15	may	may	AUX
ajird-1356	109	16	play	play	VERB
ajird-1356	109	17	roles	role	NOUN
ajird-1356	109	18	in	in	ADP
ajird-1356	109	19	the	the	DET
ajird-1356	109	20	pathogenesis	pathogenesis	NOUN
ajird-1356	109	21	.	.	PUNCT
ajird-1356	110	1	differences	difference	NOUN
ajird-1356	110	2	in	in	ADP
ajird-1356	110	3	to	to	ADP
ajird-1356	110	4	these	these	DET
ajird-1356	110	5	pathogens	pathogen	NOUN
ajird-1356	110	6	may	may	AUX
ajird-1356	110	7	also	also	ADV
ajird-1356	110	8	affect	affect	VERB
ajird-1356	110	9	disease	disease	NOUN
ajird-1356	110	10	severity	severity	NOUN
ajird-1356	110	11	and	and	CCONJ
ajird-1356	110	12	chronicity	chronicity	NOUN
ajird-1356	110	13	,	,	PUNCT
ajird-1356	110	14	but	but	CCONJ
ajird-1356	110	15	detailed	detailed	ADJ
ajird-1356	110	16	immunological	immunological	ADJ
ajird-1356	110	17	studies	study	NOUN
ajird-1356	110	18	remain	remain	VERB
ajird-1356	110	19	limited.[13,14	limited.[13,14	ADV
ajird-1356	110	20	]	]	PUNCT
ajird-1356	110	21	chronicity	chronicity	NOUN
ajird-1356	110	22	and	and	CCONJ
ajird-1356	110	23	recurrence	recurrence	NOUN
ajird-1356	110	24	.	.	PUNCT
ajird-1356	111	1	a	a	DET
ajird-1356	111	2	major	major	ADJ
ajird-1356	111	3	challenge	challenge	NOUN
ajird-1356	111	4	in	in	ADP
ajird-1356	111	5	rea	rea	PROPN
ajird-1356	111	6	is	be	AUX
ajird-1356	111	7	the	the	DET
ajird-1356	111	8	transition	transition	NOUN
ajird-1356	111	9	from	from	ADP
ajird-1356	111	10	acute	acute	NOUN
ajird-1356	111	11	,	,	PUNCT
ajird-1356	111	12	selflimiting	selflimite	VERB
ajird-1356	111	13	arthritis	arthritis	NOUN
ajird-1356	111	14	to	to	ADP
ajird-1356	111	15	chronic	chronic	VERB
ajird-1356	111	16	,	,	PUNCT
ajird-1356	111	17	recurrent	recurrent	ADJ
ajird-1356	111	18	disease	disease	NOUN
ajird-1356	111	19	.	.	PUNCT
ajird-1356	112	1	approximately	approximately	ADV
ajird-1356	112	2	30	30	NUM
ajird-1356	112	3	-	-	SYM
ajird-1356	112	4	50	50	NUM
ajird-1356	112	5	%	%	NOUN
ajird-1356	112	6	of	of	ADP
ajird-1356	112	7	patients	patient	NOUN
ajird-1356	112	8	with	with	ADP
ajird-1356	112	9	rea	rea	PROPN
ajird-1356	112	10	develop	develop	VERB
ajird-1356	112	11	a	a	DET
ajird-1356	112	12	chronic	chronic	ADJ
ajird-1356	112	13	form	form	NOUN
ajird-1356	112	14	,	,	PUNCT
ajird-1356	112	15	often	often	ADV
ajird-1356	112	16	associated	associate	VERB
ajird-1356	112	17	with	with	ADP
ajird-1356	112	18	hla	hla	PROPN
ajird-1356	112	19	-	-	PUNCT
ajird-1356	112	20	b27	b27	PROPN
ajird-1356	112	21	positivity	positivity	NOUN
ajird-1356	112	22	.	.	PUNCT
ajird-1356	113	1	the	the	DET
ajird-1356	113	2	factors	factor	NOUN
ajird-1356	113	3	that	that	PRON
ajird-1356	113	4	predict	predict	VERB
ajird-1356	113	5	chronicic	chronicic	NOUN
ajird-1356	113	6	,	,	PUNCT
ajird-1356	113	7	immunological	immunological	ADJ
ajird-1356	113	8	,	,	PUNCT
ajird-1356	113	9	and	and	CCONJ
ajird-1356	113	10	environmental	environmental	ADJ
ajird-1356	113	11	factors	factor	NOUN
ajird-1356	113	12	,	,	PUNCT
ajird-1356	113	13	are	be	AUX
ajird-1356	113	14	not	not	PART
ajird-1356	113	15	well	well	ADV
ajird-1356	113	16	defined	define	VERB
ajird-1356	113	17	.	.	PUNCT
ajird-1356	114	1	additionally	additionally	ADV
ajird-1356	114	2	,	,	PUNCT
ajird-1356	114	3	the	the	DET
ajird-1356	114	4	long	long	ADJ
ajird-1356	114	5	-	-	PUNCT
ajird-1356	114	6	term	term	NOUN
ajird-1356	114	7	outcomes	outcome	NOUN
ajird-1356	114	8	of	of	ADP
ajird-1356	114	9	patients	patient	NOUN
ajird-1356	114	10	who	who	PRON
ajird-1356	114	11	develop	develop	VERB
ajird-1356	114	12	chronic	chronic	ADJ
ajird-1356	114	13	rea	rea	NOUN
ajird-1356	114	14	are	be	AUX
ajird-1356	114	15	not	not	PART
ajird-1356	114	16	well	well	ADV
ajird-1356	114	17	documented	document	VERB
ajird-1356	114	18	,	,	PUNCT
ajird-1356	114	19	especially	especially	ADV
ajird-1356	114	20	in	in	ADP
ajird-1356	114	21	terms	term	NOUN
ajird-1356	114	22	of	of	ADP
ajird-1356	114	23	joint	joint	ADJ
ajird-1356	114	24	damage	damage	NOUN
ajird-1356	114	25	,	,	PUNCT
ajird-1356	114	26	quality	quality	NOUN
ajird-1356	114	27	of	of	ADP
ajird-1356	114	28	life	life	NOUN
ajird-1356	114	29	,	,	PUNCT
ajird-1356	114	30	and	and	CCONJ
ajird-1356	114	31	disability.[12,13,14	disability.[12,13,14	ADV
ajird-1356	114	32	]	]	PUNCT
ajird-1356	114	33	optimizing	optimize	VERB
ajird-1356	114	34	treatment	treatment	NOUN
ajird-1356	114	35	strategies	strategy	NOUN
ajird-1356	114	36	.	.	PUNCT
ajird-1356	115	1	the	the	DET
ajird-1356	115	2	treatment	treatment	NOUN
ajird-1356	115	3	of	of	ADP
ajird-1356	115	4	rea	rea	PROPN
ajird-1356	115	5	often	often	ADV
ajird-1356	115	6	begins	begin	VERB
ajird-1356	115	7	with	with	ADP
ajird-1356	115	8	nsaids	nsaid	NOUN
ajird-1356	115	9	for	for	ADP
ajird-1356	115	10	acute	acute	ADJ
ajird-1356	115	11	symptoms	symptom	NOUN
ajird-1356	115	12	,	,	PUNCT
ajird-1356	115	13	followed	follow	VERB
ajird-1356	115	14	by	by	ADP
ajird-1356	115	15	dmards	dmard	NOUN
ajird-1356	115	16	or	or	CCONJ
ajird-1356	115	17	biologics	biologic	NOUN
ajird-1356	115	18	in	in	ADP
ajird-1356	115	19	chronic	chronic	ADJ
ajird-1356	115	20	or	or	CCONJ
ajird-1356	115	21	refractory	refractory	NOUN
ajird-1356	115	22	cases	case	NOUN
ajird-1356	115	23	.	.	PUNCT
ajird-1356	116	1	while	while	SCONJ
ajird-1356	116	2	nsaids	nsaid	NOUN
ajird-1356	116	3	provide	provide	VERB
ajird-1356	116	4	symptomatic	symptomatic	ADJ
ajird-1356	116	5	relief	relief	NOUN
ajird-1356	116	6	,	,	PUNCT
ajird-1356	116	7	they	they	PRON
ajird-1356	116	8	do	do	AUX
ajird-1356	116	9	not	not	PART
ajird-1356	116	10	prevent	prevent	VERB
ajird-1356	116	11	chronicity	chronicity	NOUN
ajird-1356	116	12	.	.	PUNCT
ajird-1356	117	1	dmards	dmard	NOUN
ajird-1356	117	2	,	,	PUNCT
ajird-1356	117	3	such	such	ADJ
ajird-1356	117	4	as	as	ADP
ajird-1356	117	5	methotrexate	methotrexate	NOUN
ajird-1356	117	6	and	and	CCONJ
ajird-1356	117	7	sulfasalazine	sulfasalazine	NOUN
ajird-1356	117	8	,	,	PUNCT
ajird-1356	117	9	have	have	AUX
ajird-1356	117	10	shown	show	VERB
ajird-1356	117	11	moderate	moderate	ADJ
ajird-1356	117	12	efficacy	efficacy	NOUN
ajird-1356	117	13	,	,	PUNCT
ajird-1356	117	14	but	but	CCONJ
ajird-1356	117	15	evidence	evidence	NOUN
ajird-1356	117	16	for	for	ADP
ajird-1356	117	17	their	their	PRON
ajird-1356	117	18	longterm	longterm	ADJ
ajird-1356	117	19	benefits	benefit	NOUN
ajird-1356	117	20	remains	remain	VERB
ajird-1356	117	21	limited	limited	ADJ
ajird-1356	117	22	.	.	PUNCT
ajird-1356	118	1	biologics	biologic	NOUN
ajird-1356	118	2	,	,	PUNCT
ajird-1356	118	3	particularly	particularly	ADV
ajird-1356	118	4	tnf	tnf	PROPN
ajird-1356	118	5	inhibitors	inhibitor	NOUN
ajird-1356	118	6	,	,	PUNCT
ajird-1356	118	7	have	have	VERB
ajird-1356	118	8	demonsicacy	demonsicacy	NOUN
ajird-1356	118	9	in	in	ADP
ajird-1356	118	10	chronic	chronic	PROPN
ajird-1356	118	11	rea	rea	PROPN
ajird-1356	118	12	,	,	PUNCT
ajird-1356	118	13	but	but	CCONJ
ajird-1356	118	14	data	datum	NOUN
ajird-1356	118	15	on	on	ADP
ajird-1356	118	16	other	other	ADJ
ajird-1356	118	17	biologic	biologic	NOUN
ajird-1356	118	18	agents	agent	NOUN
ajird-1356	118	19	,	,	PUNCT
ajird-1356	118	20	such	such	ADJ
ajird-1356	118	21	as	as	ADP
ajird-1356	118	22	il-17	il-17	NUM
ajird-1356	118	23	or	or	CCONJ
ajird-1356	118	24	jak	jak	PROPN
ajird-1356	118	25	inhibitors	inhibitor	NOUN
ajird-1356	118	26	,	,	PUNCT
ajird-1356	118	27	are	be	AUX
ajird-1356	118	28	sparse	sparse	ADJ
ajird-1356	118	29	.	.	PUNCT
ajird-1356	119	1	moreover	moreover	ADV
ajird-1356	119	2	,	,	PUNCT
ajird-1356	119	3	there	there	PRON
ajird-1356	119	4	is	be	VERB
ajird-1356	119	5	limited	limited	ADJ
ajird-1356	119	6	guidance	guidance	NOUN
ajird-1356	119	7	on	on	ADP
ajird-1356	119	8	when	when	SCONJ
ajird-1356	119	9	to	to	PART
ajird-1356	119	10	escalate	escalate	VERB
ajird-1356	119	11	trebiologics	trebiologic	NOUN
ajird-1356	119	12	,	,	PUNCT
ajird-1356	119	13	especially	especially	ADV
ajird-1356	119	14	in	in	ADP
ajird-1356	119	15	hlab27	hlab27	NOUN
ajird-1356	119	16	-	-	PUNCT
ajird-1356	119	17	negative	negative	ADJ
ajird-1356	119	18	patients	patient	NOUN
ajird-1356	119	19	,	,	PUNCT
ajird-1356	119	20	who	who	PRON
ajird-1356	119	21	may	may	AUX
ajird-1356	119	22	respond	respond	VERB
ajird-1356	119	23	differently	differently	ADV
ajird-1356	119	24	.	.	PUNCT
ajird-1356	120	1	given	give	VERB
ajird-1356	120	2	the	the	DET
ajird-1356	120	3	expense	expense	NOUN
ajird-1356	120	4	and	and	CCONJ
ajird-1356	120	5	side	side	NOUN
ajird-1356	120	6	effects	effect	NOUN
ajird-1356	120	7	of	of	ADP
ajird-1356	120	8	biologic	biologic	NOUN
ajird-1356	120	9	therapy	therapy	NOUN
ajird-1356	120	10	,	,	PUNCT
ajird-1356	120	11	understanding	understand	VERB
ajird-1356	120	12	the	the	DET
ajird-1356	120	13	best	good	ADJ
ajird-1356	120	14	timing	timing	NOUN
ajird-1356	120	15	and	and	CCONJ
ajird-1356	120	16	patient	patient	ADJ
ajird-1356	120	17	selection	selection	NOUN
ajird-1356	120	18	criteria	criterion	NOUN
ajird-1356	120	19	for	for	ADP
ajird-1356	120	20	these	these	DET
ajird-1356	120	21	treatments	treatment	NOUN
ajird-1356	120	22	is	be	AUX
ajird-1356	120	23	critical.[15,16	critical.[15,16	NOUN
ajird-1356	120	24	]	]	X
ajird-1356	120	25	antibiotics	antibiotic	NOUN
ajird-1356	120	26	and	and	CCONJ
ajird-1356	120	27	preventive	preventive	ADJ
ajird-1356	120	28	therapies	therapy	NOUN
ajird-1356	120	29	.	.	PUNCT
ajird-1356	121	1	prophylactic	prophylactic	ADJ
ajird-1356	121	2	antibiotics	antibiotic	NOUN
ajird-1356	121	3	in	in	ADP
ajird-1356	121	4	preventing	prevent	VERB
ajird-1356	121	5	rea	rea	NOUN
ajird-1356	121	6	after	after	SCONJ
ajird-1356	121	7	bacterial	bacterial	ADJ
ajird-1356	121	8	infections	infection	NOUN
ajird-1356	121	9	remain	remain	VERB
ajird-1356	121	10	a	a	DET
ajird-1356	121	11	controversial	controversial	ADJ
ajird-1356	121	12	area	area	NOUN
ajird-1356	121	13	.	.	PUNCT
ajird-1356	122	1	recent	recent	ADJ
ajird-1356	122	2	studies	study	NOUN
ajird-1356	122	3	on	on	ADP
ajird-1356	122	4	the	the	DET
ajird-1356	122	5	use	use	NOUN
ajird-1356	122	6	of	of	ADP
ajird-1356	122	7	antibiotics	antibiotic	NOUN
ajird-1356	122	8	in	in	ADP
ajird-1356	122	9	the	the	DET
ajird-1356	122	10	treatment	treatment	NOUN
ajird-1356	122	11	of	of	ADP
ajird-1356	122	12	chlamydia	chlamydia	NOUN
ajird-1356	122	13	-	-	PUNCT
ajird-1356	122	14	induced	induce	VERB
ajird-1356	122	15	rea	rea	PROPN
ajird-1356	122	16	suggest	suggest	VERB
ajird-1356	122	17	mixed	mixed	ADJ
ajird-1356	122	18	results	result	NOUN
ajird-1356	122	19	.	.	PUNCT
ajird-1356	123	1	the	the	DET
ajird-1356	123	2	role	role	NOUN
ajird-1356	123	3	of	of	ADP
ajird-1356	123	4	antibiotics	antibiotic	NOUN
ajird-1356	123	5	,	,	PUNCT
ajird-1356	123	6	especially	especially	ADV
ajird-1356	123	7	in	in	ADP
ajird-1356	123	8	preventing	prevent	VERB
ajird-1356	123	9	long	long	ADJ
ajird-1356	123	10	-	-	PUNCT
ajird-1356	123	11	term	term	NOUN
ajird-1356	123	12	sequelaeshed	sequelaeshe	VERB
ajird-1356	123	13	.	.	PUNCT
ajird-1356	124	1	furthermore	furthermore	ADV
ajird-1356	124	2	,	,	PUNCT
ajird-1356	124	3	understanding	understanding	NOUN
ajird-1356	124	4	which	which	PRON
ajird-1356	124	5	patients	patient	NOUN
ajird-1356	124	6	may	may	AUX
ajird-1356	124	7	benefit	benefit	VERB
ajird-1356	124	8	from	from	ADP
ajird-1356	124	9	preventive	preventive	ADJ
ajird-1356	124	10	therapies	therapy	NOUN
ajird-1356	124	11	or	or	CCONJ
ajird-1356	124	12	early	early	ADJ
ajird-1356	124	13	interventions	intervention	NOUN
ajird-1356	124	14	remains	remain	VERB
ajird-1356	124	15	unclear.[17	unclear.[17	NOUN
ajird-1356	124	16	]	]	PUNCT
ajird-1356	124	17	biomarkers	biomarker	NOUN
ajird-1356	124	18	for	for	ADP
ajird-1356	124	19	disease	disease	NOUN
ajird-1356	124	20	activity	activity	NOUN
ajird-1356	124	21	.	.	PUNCT
ajird-1356	125	1	currently	currently	ADV
ajird-1356	125	2	,	,	PUNCT
ajird-1356	125	3	there	there	PRON
ajird-1356	125	4	are	be	VERB
ajird-1356	125	5	no	no	DET
ajird-1356	125	6	reliable	reliable	ADJ
ajird-1356	125	7	biomarkers	biomarker	NOUN
ajird-1356	125	8	that	that	PRON
ajird-1356	125	9	can	can	AUX
ajird-1356	125	10	predict	predict	VERB
ajird-1356	125	11	the	the	DET
ajird-1356	125	12	onset	onset	NOUN
ajird-1356	125	13	,	,	PUNCT
ajird-1356	125	14	severity	severity	NOUN
ajird-1356	125	15	,	,	PUNCT
ajird-1356	125	16	or	or	CCONJ
ajird-1356	125	17	recurrence	recurrence	NOUN
ajird-1356	125	18	of	of	ADP
ajird-1356	125	19	rea	rea	PROPN
ajird-1356	125	20	.	.	PUNCT
ajird-1356	126	1	while	while	SCONJ
ajird-1356	126	2	inflammatory	inflammatory	ADJ
ajird-1356	126	3	markers	marker	NOUN
ajird-1356	126	4	such	such	ADJ
ajird-1356	126	5	as	as	ADP
ajird-1356	126	6	creactive	creactive	ADJ
ajird-1356	126	7	protein	protein	NOUN
ajird-1356	126	8	(	(	PUNCT
ajird-1356	126	9	crp	crp	NOUN
ajird-1356	126	10	)	)	PUNCT
ajird-1356	126	11	and	and	CCONJ
ajird-1356	126	12	erythrocyte	erythrocyte	PROPN
ajird-1356	126	13	sedimentation	sedimentation	NOUN
ajird-1356	126	14	rate	rate	NOUN
ajird-1356	126	15	(	(	PUNCT
ajird-1356	126	16	esr	esr	PROPN
ajird-1356	126	17	)	)	PUNCT
ajird-1356	126	18	are	be	AUX
ajird-1356	126	19	commonly	commonly	ADV
ajird-1356	126	20	used	use	VERB
ajird-1356	126	21	,	,	PUNCT
ajird-1356	126	22	they	they	PRON
ajird-1356	126	23	lack	lack	VERB
ajird-1356	126	24	specificity	specificity	NOUN
ajird-1356	126	25	and	and	CCONJ
ajird-1356	126	26	sensitivity	sensitivity	NOUN
ajird-1356	126	27	for	for	ADP
ajird-1356	126	28	rea	rea	PROPN
ajird-1356	126	29	.	.	PROPN
ajird-1356	126	30	advances	advance	NOUN
ajird-1356	126	31	in	in	ADP
ajird-1356	126	32	understanding	understand	VERB
ajird-1356	126	33	the	the	DET
ajird-1356	126	34	molecular	molecular	ADJ
ajird-1356	126	35	pathways	pathway	NOUN
ajird-1356	126	36	american	american	ADJ
ajird-1356	126	37	journal	journal	PROPN
ajird-1356	126	38	of	of	ADP
ajird-1356	126	39	interdisciplinary	interdisciplinary	ADJ
ajird-1356	126	40	research	research	NOUN
ajird-1356	126	41	and	and	CCONJ
ajird-1356	126	42	development	development	NOUN
ajird-1356	126	43	issn	issn	PROPN
ajird-1356	126	44	online	online	NOUN
ajird-1356	126	45	:	:	PUNCT
ajird-1356	126	46	2771	2771	NUM
ajird-1356	126	47	-	-	SYM
ajird-1356	126	48	8948	8948	NUM
ajird-1356	126	49	website	website	NOUN
ajird-1356	126	50	:	:	PUNCT
ajird-1356	126	51	www.ajird.journalspark.org	www.ajird.journalspark.org	ADJ
ajird-1356	126	52	volume	volume	NOUN
ajird-1356	126	53	34	34	NUM
ajird-1356	126	54	,	,	PUNCT
ajird-1356	126	55	november	november	PROPN
ajird-1356	126	56	2024	2024	NUM
ajird-1356	126	57	37	37	NUM
ajird-1356	126	58	|	|	ADV
ajird-1356	126	59	p	p	NOUN
ajird-1356	126	60	a	a	DET
ajird-1356	126	61	g	g	NOUN
ajird-1356	126	62	e	e	NOUN
ajird-1356	126	63	of	of	ADP
ajird-1356	126	64	spondyloarthritis	spondyloarthritis	NOUN
ajird-1356	126	65	could	could	AUX
ajird-1356	126	66	help	help	AUX
ajird-1356	126	67	identify	identify	VERB
ajird-1356	126	68	novel	novel	ADJ
ajird-1356	126	69	biomarkers	biomarker	NOUN
ajird-1356	126	70	for	for	ADP
ajird-1356	126	71	disease	disease	NOUN
ajird-1356	126	72	activity	activity	NOUN
ajird-1356	126	73	,	,	PUNCT
ajird-1356	126	74	treatment	treatment	NOUN
ajird-1356	126	75	response	response	NOUN
ajird-1356	126	76	,	,	PUNCT
ajird-1356	126	77	and	and	CCONJ
ajird-1356	126	78	prognosis	prognosis	NOUN
ajird-1356	126	79	.	.	PUNCT
ajird-1356	127	1	impact	impact	NOUN
ajird-1356	127	2	of	of	ADP
ajird-1356	127	3	lifestyle	lifestyle	NOUN
ajird-1356	127	4	and	and	CCONJ
ajird-1356	127	5	environmental	environmental	ADJ
ajird-1356	127	6	factors	factor	NOUN
ajird-1356	127	7	there	there	PRON
ajird-1356	127	8	is	be	VERB
ajird-1356	127	9	limited	limited	ADJ
ajird-1356	127	10	research	research	NOUN
ajird-1356	127	11	on	on	ADP
ajird-1356	127	12	the	the	DET
ajird-1356	127	13	role	role	NOUN
ajird-1356	127	14	of	of	ADP
ajird-1356	127	15	lifestyle	lifestyle	NOUN
ajird-1356	127	16	factors	factor	NOUN
ajird-1356	127	17	(	(	PUNCT
ajird-1356	127	18	such	such	ADJ
ajird-1356	127	19	as	as	ADP
ajird-1356	127	20	diet	diet	NOUN
ajird-1356	127	21	,	,	PUNCT
ajird-1356	127	22	smoking	smoking	NOUN
ajird-1356	127	23	,	,	PUNCT
ajird-1356	127	24	and	and	CCONJ
ajird-1356	127	25	exercise	exercise	NOUN
ajird-1356	127	26	)	)	PUNCT
ajird-1356	127	27	and	and	CCONJ
ajird-1356	127	28	environmental	environmental	ADJ
ajird-1356	127	29	exposures	exposure	NOUN
ajird-1356	127	30	in	in	ADP
ajird-1356	127	31	the	the	DET
ajird-1356	127	32	development	development	NOUN
ajird-1356	127	33	and	and	CCONJ
ajird-1356	127	34	progression	progression	NOUN
ajird-1356	127	35	of	of	ADP
ajird-1356	127	36	rea	rea	PROPN
ajird-1356	127	37	.	.	PUNCT
ajird-1356	128	1	these	these	DET
ajird-1356	128	2	factors	factor	NOUN
ajird-1356	128	3	have	have	AUX
ajird-1356	128	4	been	be	AUX
ajird-1356	128	5	implicated	implicate	VERB
ajird-1356	128	6	in	in	ADP
ajird-1356	128	7	other	other	ADJ
ajird-1356	128	8	forms	form	NOUN
ajird-1356	128	9	of	of	ADP
ajird-1356	128	10	spondyloarthritis	spondyloarthritis	NOUN
ajird-1356	128	11	and	and	CCONJ
ajird-1356	128	12	may	may	AUX
ajird-1356	128	13	also	also	ADV
ajird-1356	128	14	influence	influence	VERB
ajird-1356	128	15	outcomes	outcome	NOUN
ajird-1356	128	16	in	in	ADP
ajird-1356	128	17	rea	rea	PROPN
ajird-1356	128	18	.	.	PUNCT
ajird-1356	129	1	the	the	DET
ajird-1356	129	2	gut	gut	NOUN
ajird-1356	129	3	microbiome	microbiome	NOUN
ajird-1356	129	4	,	,	PUNCT
ajird-1356	129	5	for	for	ADP
ajird-1356	129	6	instance	instance	NOUN
ajird-1356	129	7	,	,	PUNCT
ajird-1356	129	8	has	have	AUX
ajird-1356	129	9	gained	gain	VERB
ajird-1356	129	10	attention	attention	NOUN
ajird-1356	129	11	as	as	ADP
ajird-1356	129	12	a	a	DET
ajird-1356	129	13	potential	potential	ADJ
ajird-1356	129	14	modulator	modulator	NOUN
ajird-1356	129	15	of	of	ADP
ajird-1356	129	16	inflammatory	inflammatory	ADJ
ajird-1356	129	17	diseases	disease	NOUN
ajird-1356	129	18	,	,	PUNCT
ajird-1356	129	19	and	and	CCONJ
ajird-1356	129	20	its	its	PRON
ajird-1356	129	21	role	role	NOUN
ajird-1356	129	22	in	in	ADP
ajird-1356	129	23	rea	rea	PROPN
ajird-1356	129	24	should	should	AUX
ajird-1356	129	25	be	be	AUX
ajird-1356	129	26	explored	explore	VERB
ajird-1356	129	27	.	.	PUNCT
ajird-1356	130	1	references	reference	NOUN
ajird-1356	130	2	:	:	PUNCT
ajird-1356	131	1	1	1	X
ajird-1356	131	2	.	.	X
ajird-1356	131	3	hannu	hannu	PROPN
ajird-1356	131	4	,	,	PUNCT
ajird-1356	131	5	t.	t.	PROPN
ajird-1356	131	6	(	(	PUNCT
ajird-1356	131	7	2011	2011	NUM
ajird-1356	131	8	)	)	PUNCT
ajird-1356	131	9	.	.	PUNCT
ajird-1356	132	1	reactive	reactive	ADJ
ajird-1356	132	2	arthritis	arthritis	NOUN
ajird-1356	132	3	.	.	PUNCT
ajird-1356	133	1	best	good	ADJ
ajird-1356	133	2	practice	practice	PROPN
ajird-1356	133	3	&	&	CCONJ
ajird-1356	133	4	research	research	PROPN
ajird-1356	133	5	clinical	clinical	ADJ
ajird-1356	133	6	rheumatology	rheumatology	NOUN
ajird-1356	133	7	,	,	PUNCT
ajird-1356	133	8	25(3	25(3	NUM
ajird-1356	133	9	)	)	PUNCT
ajird-1356	133	10	,	,	PUNCT
ajird-1356	133	11	347	347	NUM
ajird-1356	133	12	-	-	SYM
ajird-1356	133	13	357	357	NUM
ajird-1356	133	14	.	.	PUNCT
ajird-1356	134	1	https://doi.org/10.1016/j.berh.2011.01.019	https://doi.org/10.1016/j.berh.2011.01.019	NUM
ajird-1356	134	2	2	2	NUM
ajird-1356	134	3	.	.	PUNCT
ajird-1356	134	4	coates	coate	NOUN
ajird-1356	134	5	,	,	PUNCT
ajird-1356	134	6	l.	l.	PROPN
ajird-1356	134	7	c.	c.	PROPN
ajird-1356	134	8	,	,	PUNCT
ajird-1356	134	9	&	&	CCONJ
ajird-1356	134	10	helliwell	helliwell	PROPN
ajird-1356	134	11	,	,	PUNCT
ajird-1356	134	12	p.	p.	PROPN
ajird-1356	134	13	s.	s.	PROPN
ajird-1356	134	14	(	(	PUNCT
ajird-1356	134	15	2017	2017	NUM
ajird-1356	134	16	)	)	PUNCT
ajird-1356	134	17	.	.	PUNCT
ajird-1356	135	1	treating	treat	VERB
ajird-1356	135	2	reactive	reactive	ADJ
ajird-1356	135	3	arthritis	arthritis	NOUN
ajird-1356	135	4	.	.	PUNCT
ajird-1356	136	1	rheumatic	rheumatic	ADJ
ajird-1356	136	2	disease	disease	NOUN
ajird-1356	136	3	clinics	clinic	NOUN
ajird-1356	136	4	of	of	ADP
ajird-1356	136	5	north	north	PROPN
ajird-1356	136	6	america	america	PROPN
ajird-1356	136	7	,	,	PUNCT
ajird-1356	136	8	43(1	43(1	NOUN
ajird-1356	136	9	)	)	PUNCT
ajird-1356	136	10	,	,	PUNCT
ajird-1356	136	11	63	63	NUM
ajird-1356	136	12	-	-	SYM
ajird-1356	136	13	74	74	NUM
ajird-1356	136	14	.	.	PUNCT
ajird-1356	137	1	https://doi.org/10.1016/j.rdc.2016.09.003	https://doi.org/10.1016/j.rdc.2016.09.003	NOUN
ajird-1356	137	2	3	3	NUM
ajird-1356	137	3	.	.	PUNCT
ajird-1356	137	4	mchugh	mchugh	PROPN
ajird-1356	137	5	,	,	PUNCT
ajird-1356	137	6	k.	k.	PROPN
ajird-1356	137	7	,	,	PUNCT
ajird-1356	137	8	&	&	CCONJ
ajird-1356	137	9	bowness	bowness	PROPN
ajird-1356	137	10	,	,	PUNCT
ajird-1356	137	11	p.	p.	NOUN
ajird-1356	137	12	(	(	PUNCT
ajird-1356	137	13	2021	2021	NUM
ajird-1356	137	14	)	)	PUNCT
ajird-1356	137	15	.	.	PUNCT
ajird-1356	138	1	the	the	DET
ajird-1356	138	2	link	link	NOUN
ajird-1356	138	3	between	between	ADP
ajird-1356	138	4	hla	hla	PROPN
ajird-1356	138	5	-	-	PUNCT
ajird-1356	138	6	b27	b27	PROPN
ajird-1356	138	7	and	and	CCONJ
ajird-1356	138	8	the	the	DET
ajird-1356	138	9	pathogenesis	pathogenesis	NOUN
ajird-1356	138	10	of	of	ADP
ajird-1356	138	11	reactive	reactive	ADJ
ajird-1356	138	12	arthritis	arthritis	NOUN
ajird-1356	138	13	.	.	PUNCT
ajird-1356	139	1	seminars	seminar	NOUN
ajird-1356	139	2	in	in	ADP
ajird-1356	139	3	immunopathology	immunopathology	NOUN
ajird-1356	139	4	,	,	PUNCT
ajird-1356	139	5	43(2	43(2	NUM
ajird-1356	139	6	)	)	PUNCT
ajird-1356	139	7	,	,	PUNCT
ajird-1356	139	8	251	251	NUM
ajird-1356	139	9	-	-	SYM
ajird-1356	139	10	266	266	NUM
ajird-1356	139	11	.	.	PUNCT
ajird-1356	140	1	https://doi.org/10.1007/s00281-021-00847-z	https://doi.org/10.1007/s00281-021-00847-z	NOUN
ajird-1356	140	2	4	4	NUM
ajird-1356	140	3	.	.	PUNCT
ajird-1356	140	4	golder	golder	NOUN
ajird-1356	140	5	,	,	PUNCT
ajird-1356	140	6	v.	v.	ADV
ajird-1356	140	7	,	,	PUNCT
ajird-1356	140	8	&	&	CCONJ
ajird-1356	140	9	schachna	schachna	PROPN
ajird-1356	140	10	,	,	PUNCT
ajird-1356	140	11	l.	l.	PROPN
ajird-1356	140	12	(	(	PUNCT
ajird-1356	140	13	2020	2020	NUM
ajird-1356	140	14	)	)	PUNCT
ajird-1356	140	15	.	.	PUNCT
ajird-1356	141	1	reactive	reactive	ADJ
ajird-1356	141	2	arthritis	arthritis	NOUN
ajird-1356	141	3	:	:	PUNCT
ajird-1356	141	4	advances	advance	NOUN
ajird-1356	141	5	in	in	ADP
ajird-1356	141	6	diagnosis	diagnosis	NOUN
ajird-1356	141	7	and	and	CCONJ
ajird-1356	141	8	management	management	NOUN
ajird-1356	141	9	.	.	PUNCT
ajird-1356	142	1	journal	journal	NOUN
ajird-1356	142	2	of	of	ADP
ajird-1356	142	3	clinical	clinical	ADJ
ajird-1356	142	4	rheumatology	rheumatology	NOUN
ajird-1356	142	5	,	,	PUNCT
ajird-1356	142	6	26(3	26(3	NUM
ajird-1356	142	7	)	)	PUNCT
ajird-1356	142	8	,	,	PUNCT
ajird-1356	142	9	108	108	NUM
ajird-1356	142	10	-	-	SYM
ajird-1356	142	11	114	114	NUM
ajird-1356	142	12	.	.	PUNCT
ajird-1356	143	1	https://doi.org/10.1097/rhu.0000000000001077	https://doi.org/10.1097/rhu.0000000000001077	PROPN
ajird-1356	143	2	5	5	NUM
ajird-1356	143	3	.	.	PUNCT
ajird-1356	143	4	kivity	kivity	PROPN
ajird-1356	143	5	,	,	PUNCT
ajird-1356	143	6	s.	s.	PROPN
ajird-1356	143	7	,	,	PUNCT
ajird-1356	143	8	agmon	agmon	PROPN
ajird-1356	143	9	-	-	PUNCT
ajird-1356	143	10	levin	levin	PROPN
ajird-1356	143	11	,	,	PUNCT
ajird-1356	143	12	n.	n.	NOUN
ajird-1356	143	13	,	,	PUNCT
ajird-1356	143	14	blank	blank	ADJ
ajird-1356	143	15	,	,	PUNCT
ajird-1356	143	16	m.	m.	NOUN
ajird-1356	143	17	,	,	PUNCT
ajird-1356	143	18	&	&	CCONJ
ajird-1356	143	19	shoenfeld	shoenfeld	PROPN
ajird-1356	143	20	,	,	PUNCT
ajird-1356	143	21	y.	y.	PROPN
ajird-1356	143	22	(	(	PUNCT
ajird-1356	143	23	2014	2014	NUM
ajird-1356	143	24	)	)	PUNCT
ajird-1356	143	25	.	.	PUNCT
ajird-1356	144	1	infections	infection	NOUN
ajird-1356	144	2	and	and	CCONJ
ajird-1356	144	3	autoimmunity	autoimmunity	NOUN
ajird-1356	144	4	—	—	PUNCT
ajird-1356	144	5	friends	friend	NOUN
ajird-1356	144	6	or	or	CCONJ
ajird-1356	144	7	foes	foe	NOUN
ajird-1356	144	8	?	?	PUNCT
ajird-1356	145	1	trends	trend	NOUN
ajird-1356	145	2	in	in	ADP
ajird-1356	145	3	immunology	immunology	NOUN
ajird-1356	145	4	,	,	PUNCT
ajird-1356	145	5	35(2	35(2	NUM
ajird-1356	145	6	)	)	PUNCT
ajird-1356	145	7	,	,	PUNCT
ajird-1356	145	8	102	102	NUM
ajird-1356	145	9	-	-	SYM
ajird-1356	145	10	110	110	NUM
ajird-1356	145	11	.	.	PUNCT
ajird-1356	146	1	https://doi.org/10.1016/j.it.2013.10.001	https://doi.org/10.1016/j.it.2013.10.001	PROPN
ajird-1356	146	2	6	6	NUM
ajird-1356	146	3	.	.	PUNCT
ajird-1356	147	1	nisar	nisar	PROPN
ajird-1356	147	2	,	,	PUNCT
ajird-1356	147	3	m.	m.	PROPN
ajird-1356	147	4	k.	k.	PROPN
ajird-1356	147	5	,	,	PUNCT
ajird-1356	147	6	luqmani	luqmani	PROPN
ajird-1356	147	7	,	,	PUNCT
ajird-1356	147	8	r.	r.	PROPN
ajird-1356	147	9	,	,	PUNCT
ajird-1356	147	10	&	&	CCONJ
ajird-1356	147	11	kumar	kumar	PROPN
ajird-1356	147	12	,	,	PUNCT
ajird-1356	147	13	n.	n.	PROPN
ajird-1356	147	14	(	(	PUNCT
ajird-1356	147	15	2019	2019	NUM
ajird-1356	147	16	)	)	PUNCT
ajird-1356	147	17	.	.	PUNCT
ajird-1356	148	1	reactive	reactive	ADJ
ajird-1356	148	2	arthritis	arthritis	NOUN
ajird-1356	148	3	:	:	PUNCT
ajird-1356	148	4	patterns	pattern	NOUN
ajird-1356	148	5	of	of	ADP
ajird-1356	148	6	chronicity	chronicity	NOUN
ajird-1356	148	7	and	and	CCONJ
ajird-1356	148	8	treatment	treatment	NOUN
ajird-1356	148	9	outcomes	outcome	NOUN
ajird-1356	148	10	in	in	ADP
ajird-1356	148	11	a	a	DET
ajird-1356	148	12	real	real	ADJ
ajird-1356	148	13	-	-	PUNCT
ajird-1356	148	14	world	world	NOUN
ajird-1356	148	15	cohort	cohort	NOUN
ajird-1356	148	16	.	.	PUNCT
ajird-1356	149	1	rheumatology	rheumatology	NOUN
ajird-1356	149	2	advances	advance	VERB
ajird-1356	149	3	in	in	ADP
ajird-1356	149	4	practice	practice	NOUN
ajird-1356	149	5	,	,	PUNCT
ajird-1356	149	6	3(2	3(2	NUM
ajird-1356	149	7	)	)	PUNCT
ajird-1356	149	8	,	,	PUNCT
ajird-1356	149	9	rkz032	rkz032	PROPN
ajird-1356	149	10	.	.	PUNCT
ajird-1356	150	1	https://doi.org/10.1093/rap/rkz032	https://doi.org/10.1093/rap/rkz032	PROPN
ajird-1356	150	2	7	7	NUM
ajird-1356	150	3	.	.	PUNCT
ajird-1356	151	1	wendling	wendle	VERB
ajird-1356	151	2	,	,	PUNCT
ajird-1356	151	3	d.	d.	PROPN
ajird-1356	151	4	,	,	PUNCT
ajird-1356	151	5	&	&	CCONJ
ajird-1356	151	6	prati	prati	PROPN
ajird-1356	151	7	,	,	PUNCT
ajird-1356	151	8	c.	c.	PROPN
ajird-1356	151	9	(	(	PUNCT
ajird-1356	151	10	2022	2022	NUM
ajird-1356	151	11	)	)	PUNCT
ajird-1356	151	12	.	.	PUNCT
ajird-1356	152	1	role	role	NOUN
ajird-1356	152	2	of	of	ADP
ajird-1356	152	3	tnf	tnf	PROPN
ajird-1356	152	4	inhibitors	inhibitor	NOUN
ajird-1356	152	5	in	in	ADP
ajird-1356	152	6	reactive	reactive	ADJ
ajird-1356	152	7	arthritis	arthritis	NOUN
ajird-1356	152	8	:	:	PUNCT
ajird-1356	152	9	a	a	DET
ajird-1356	152	10	review	review	NOUN
ajird-1356	152	11	.	.	PUNCT
ajird-1356	153	1	expert	expert	NOUN
ajird-1356	153	2	review	review	NOUN
ajird-1356	153	3	of	of	ADP
ajird-1356	153	4	clinical	clinical	ADJ
ajird-1356	153	5	immunology	immunology	NOUN
ajird-1356	153	6	,	,	PUNCT
ajird-1356	153	7	18(3	18(3	NUM
ajird-1356	153	8	)	)	PUNCT
ajird-1356	153	9	,	,	PUNCT
ajird-1356	153	10	251	251	NUM
ajird-1356	153	11	-	-	SYM
ajird-1356	153	12	260	260	NUM
ajird-1356	153	13	.	.	PUNCT
ajird-1356	153	14	https://doi.org/10.1080/1744666x.2022.2032935	https://doi.org/10.1080/1744666x.2022.2032935	PROPN
ajird-1356	153	15	8	8	NUM
ajird-1356	153	16	.	.	PUNCT
ajird-1356	154	1	nisar	nisar	PROPN
ajird-1356	154	2	,	,	PUNCT
ajird-1356	154	3	m.	m.	PROPN
ajird-1356	154	4	k.	k.	PROPN
ajird-1356	154	5	,	,	PUNCT
ajird-1356	154	6	et	et	PROPN
ajird-1356	154	7	al	al	PROPN
ajird-1356	154	8	.	.	PROPN
ajird-1356	155	1	(	(	PUNCT
ajird-1356	155	2	2019	2019	NUM
ajird-1356	155	3	)	)	PUNCT
ajird-1356	155	4	.	.	PUNCT
ajird-1356	156	1	reactive	reactive	ADJ
ajird-1356	156	2	arthritis	arthritis	NOUN
ajird-1356	156	3	:	:	PUNCT
ajird-1356	156	4	patterns	pattern	NOUN
ajird-1356	156	5	of	of	ADP
ajird-1356	156	6	chronicity	chronicity	NOUN
ajird-1356	156	7	and	and	CCONJ
ajird-1356	156	8	treatment	treatment	NOUN
ajird-1356	156	9	outcomes	outcome	NOUN
ajird-1356	156	10	.	.	PUNCT
ajird-1356	157	1	rheumatology	rheumatology	NOUN
ajird-1356	157	2	advances	advance	VERB
ajird-1356	157	3	in	in	ADP
ajird-1356	157	4	practice	practice	NOUN
ajird-1356	157	5	,	,	PUNCT
ajird-1356	157	6	3(2	3(2	NUM
ajird-1356	157	7	)	)	PUNCT
ajird-1356	157	8	,	,	PUNCT
ajird-1356	157	9	rkz032	rkz032	PROPN
ajird-1356	157	10	.	.	PUNCT
ajird-1356	158	1	https://doi.org/10.1093/rap/rkz032	https://doi.org/10.1093/rap/rkz032	NOUN
ajird-1356	158	2	9	9	NUM
ajird-1356	158	3	.	.	PUNCT
ajird-1356	159	1	coates	coate	NOUN
ajird-1356	159	2	,	,	PUNCT
ajird-1356	159	3	l.	l.	PROPN
ajird-1356	159	4	c.	c.	PROPN
ajird-1356	159	5	,	,	PUNCT
ajird-1356	159	6	&	&	CCONJ
ajird-1356	159	7	marzo	marzo	PROPN
ajird-1356	159	8	-	-	PUNCT
ajird-1356	159	9	ortega	ortega	PROPN
ajird-1356	159	10	,	,	PUNCT
ajird-1356	159	11	h.	h.	PROPN
ajird-1356	159	12	(	(	PUNCT
ajird-1356	159	13	2019	2019	NUM
ajird-1356	159	14	)	)	PUNCT
ajird-1356	159	15	.	.	PUNCT
ajird-1356	160	1	rheumatic	rheumatic	ADJ
ajird-1356	160	2	disease	disease	NOUN
ajird-1356	160	3	management	management	NOUN
ajird-1356	160	4	:	:	PUNCT
ajird-1356	160	5	real	real	ADJ
ajird-1356	160	6	-	-	PUNCT
ajird-1356	160	7	world	world	NOUN
ajird-1356	160	8	efficacy	efficacy	NOUN
ajird-1356	160	9	of	of	ADP
ajird-1356	160	10	biologic	biologic	NOUN
ajird-1356	160	11	agents	agent	NOUN
ajird-1356	160	12	in	in	ADP
ajird-1356	160	13	reactive	reactive	ADJ
ajird-1356	160	14	arthritis	arthritis	NOUN
ajird-1356	160	15	.	.	PUNCT
ajird-1356	161	1	rheumatology	rheumatology	PROPN
ajird-1356	161	2	international	international	PROPN
ajird-1356	161	3	,	,	PUNCT
ajird-1356	161	4	39(1	39(1	NUM
ajird-1356	161	5	)	)	PUNCT
ajird-1356	161	6	,	,	PUNCT
ajird-1356	161	7	5562	5562	NUM
ajird-1356	161	8	.	.	PUNCT
ajird-1356	162	1	https://doi.org/10.1007/s00296-019-4265-7	https://doi.org/10.1007/s00296-019-4265-7	NUM
ajird-1356	162	2	10	10	NUM
ajird-1356	162	3	.	.	PUNCT
ajird-1356	163	1	garcía	garcía	ADJ
ajird-1356	163	2	-	-	PUNCT
ajird-1356	163	3	kutzbach	kutzbach	NOUN
ajird-1356	163	4	a	a	NOUN
ajird-1356	163	5	,	,	PUNCT
ajird-1356	163	6	chacón	chacón	PROPN
ajird-1356	163	7	-	-	PUNCT
ajird-1356	163	8	súchite	súchite	PROPN
ajird-1356	163	9	j	j	PROPN
ajird-1356	163	10	,	,	PUNCT
ajird-1356	163	11	garcía	garcía	PROPN
ajird-1356	163	12	-	-	PUNCT
ajird-1356	163	13	ferrer	ferrer	PROPN
ajird-1356	163	14	h	h	PROPN
ajird-1356	163	15	,	,	PUNCT
ajird-1356	163	16	iraheta	iraheta	PROPN
ajird-1356	163	17	i.	i.	PROPN
ajird-1356	163	18	reactive	reactive	PROPN
ajird-1356	163	19	arthritis	arthritis	NOUN
ajird-1356	163	20	:	:	PUNCT
ajird-1356	163	21	update	update	NOUN
ajird-1356	163	22	2018	2018	NUM
ajird-1356	163	23	.	.	PUNCT
ajird-1356	164	1	clin	clin	PROPN
ajird-1356	164	2	rheumatol	rheumatol	NOUN
ajird-1356	164	3	.	.	PUNCT
ajird-1356	165	1	2018;37:869–74	2018;37:869–74	X
ajird-1356	165	2	.	.	PUNCT
ajird-1356	166	1	https://doi.org/10.1007/s10067-0184022-5	https://doi.org/10.1007/s10067-0184022-5	PROPN
ajird-1356	166	2	.	.	PUNCT
ajird-1356	167	1	https://doi.org/10.1016/j.berh.2011.01.019	https://doi.org/10.1016/j.berh.2011.01.019	PROPN
ajird-1356	167	2	https://doi.org/10.1016/j.rdc.2016.09.003	https://doi.org/10.1016/j.rdc.2016.09.003	PROPN
ajird-1356	167	3	https://doi.org/10.1007/s00281-021-00847-z	https://doi.org/10.1007/s00281-021-00847-z	PROPN
ajird-1356	167	4	https://doi.org/10.1097/rhu.0000000000001077	https://doi.org/10.1097/rhu.0000000000001077	PROPN
ajird-1356	167	5	https://doi.org/10.1016/j.it.2013.10.001	https://doi.org/10.1016/j.it.2013.10.001	PROPN
ajird-1356	167	6	https://doi.org/10.1093/rap/rkz032	https://doi.org/10.1093/rap/rkz032	PROPN
ajird-1356	167	7	https://doi.org/10.1080/1744666x.2022.2032935	https://doi.org/10.1080/1744666x.2022.2032935	PROPN
ajird-1356	167	8	https://doi.org/10.1093/rap/rkz032	https://doi.org/10.1093/rap/rkz032	PROPN
ajird-1356	167	9	https://doi.org/10.1007/s00296-019-4265-7	https://doi.org/10.1007/s00296-019-4265-7	NUM
ajird-1356	167	10	american	american	ADJ
ajird-1356	167	11	journal	journal	PROPN
ajird-1356	167	12	of	of	ADP
ajird-1356	167	13	interdisciplinary	interdisciplinary	ADJ
ajird-1356	167	14	research	research	NOUN
ajird-1356	167	15	and	and	CCONJ
ajird-1356	167	16	development	development	NOUN
ajird-1356	167	17	issn	issn	PROPN
ajird-1356	167	18	online	online	NOUN
ajird-1356	167	19	:	:	PUNCT
ajird-1356	167	20	2771	2771	NUM
ajird-1356	167	21	-	-	SYM
ajird-1356	167	22	8948	8948	NUM
ajird-1356	167	23	website	website	NOUN
ajird-1356	167	24	:	:	PUNCT
ajird-1356	167	25	www.ajird.journalspark.org	www.ajird.journalspark.org	ADJ
ajird-1356	167	26	volume	volume	NOUN
ajird-1356	167	27	34	34	NUM
ajird-1356	167	28	,	,	PUNCT
ajird-1356	167	29	november	november	PROPN
ajird-1356	167	30	2024	2024	NUM
ajird-1356	167	31	38	38	NUM
ajird-1356	167	32	|	|	ADV
ajird-1356	167	33	p	p	NOUN
ajird-1356	167	34	a	a	DET
ajird-1356	167	35	g	g	NOUN
ajird-1356	167	36	e	e	NOUN
ajird-1356	167	37	11	11	NUM
ajird-1356	167	38	.	.	PUNCT
ajird-1356	168	1	2	2	NUM
ajird-1356	168	2	.	.	X
ajird-1356	168	3	schmitt	schmitt	PROPN
ajird-1356	168	4	sk	sk	PROPN
ajird-1356	168	5	.	.	PROPN
ajird-1356	168	6	reactive	reactive	ADJ
ajird-1356	168	7	arthritis	arthritis	NOUN
ajird-1356	168	8	.	.	PUNCT
ajird-1356	169	1	infect	infect	VERB
ajird-1356	169	2	dis	dis	PROPN
ajird-1356	169	3	clin	clin	PROPN
ajird-1356	169	4	n	n	PRON
ajird-1356	169	5	am	be	AUX
ajird-1356	169	6	.	.	PUNCT
ajird-1356	170	1	2017;31:265–77	2017;31:265–77	X
ajird-1356	170	2	.	.	PUNCT
ajird-1356	171	1	https://doi.org/10.1016/j.idc.2017.01.002	https://doi.org/10.1016/j.idc.2017.01.002	PROPN
ajird-1356	171	2	.	.	PROPN
ajird-1356	171	3	12	12	NUM
ajird-1356	171	4	.	.	PUNCT
ajird-1356	171	5	sieper	sieper	PROPN
ajird-1356	171	6	,	,	PUNCT
ajird-1356	171	7	j.	j.	PROPN
ajird-1356	171	8	,	,	PUNCT
ajird-1356	171	9	&	&	CCONJ
ajird-1356	171	10	braun	braun	PROPN
ajird-1356	171	11	,	,	PUNCT
ajird-1356	171	12	j.	j.	PROPN
ajird-1356	171	13	(	(	PUNCT
ajird-1356	171	14	2022	2022	NUM
ajird-1356	171	15	)	)	PUNCT
ajird-1356	171	16	.	.	PUNCT
ajird-1356	172	1	management	management	NOUN
ajird-1356	172	2	strategies	strategy	NOUN
ajird-1356	172	3	for	for	ADP
ajird-1356	172	4	chronic	chronic	ADJ
ajird-1356	172	5	reactive	reactive	NOUN
ajird-1356	172	6	arthritis	arthritis	NOUN
ajird-1356	172	7	in	in	ADP
ajird-1356	172	8	the	the	DET
ajird-1356	172	9	era	era	NOUN
ajird-1356	172	10	of	of	ADP
ajird-1356	172	11	biologics	biologic	NOUN
ajird-1356	172	12	.	.	PUNCT
ajird-1356	173	1	rheumatology	rheumatology	NOUN
ajird-1356	173	2	(	(	PUNCT
ajird-1356	173	3	oxford	oxford	PROPN
ajird-1356	173	4	)	)	PUNCT
ajird-1356	173	5	,	,	PUNCT
ajird-1356	173	6	61(suppl	61(suppl	NUM
ajird-1356	173	7	2	2	NUM
ajird-1356	173	8	)	)	PUNCT
ajird-1356	173	9	,	,	PUNCT
ajird-1356	173	10	ii10	ii10	PROPN
ajird-1356	173	11	-	-	PUNCT
ajird-1356	173	12	ii16	ii16	PROPN
ajird-1356	173	13	.	.	PUNCT
ajird-1356	174	1	https://doi.org/10.1093/rheumatology/keab118	https://doi.org/10.1093/rheumatology/keab118	X
ajird-1356	175	1	13	13	NUM
ajird-1356	175	2	.	.	PUNCT
ajird-1356	176	1	thomas	thomas	PROPN
ajird-1356	176	2	,	,	PUNCT
ajird-1356	176	3	s.	s.	PROPN
ajird-1356	176	4	,	,	PUNCT
ajird-1356	176	5	&	&	CCONJ
ajird-1356	176	6	marson	marson	PROPN
ajird-1356	176	7	,	,	PUNCT
ajird-1356	176	8	e.	e.	PROPN
ajird-1356	176	9	j.	j.	PROPN
ajird-1356	176	10	(	(	PUNCT
ajird-1356	176	11	2019	2019	NUM
ajird-1356	176	12	)	)	PUNCT
ajird-1356	176	13	.	.	PUNCT
ajird-1356	177	1	reactive	reactive	ADJ
ajird-1356	177	2	arthritis	arthritis	NOUN
ajird-1356	177	3	in	in	ADP
ajird-1356	177	4	post	post	ADJ
ajird-1356	177	5	-	-	ADJ
ajird-1356	177	6	enteric	enteric	ADJ
ajird-1356	177	7	infections	infection	NOUN
ajird-1356	177	8	:	:	PUNCT
ajird-1356	177	9	a	a	DET
ajird-1356	177	10	systematic	systematic	ADJ
ajird-1356	177	11	review	review	NOUN
ajird-1356	177	12	and	and	CCONJ
ajird-1356	177	13	meta	meta	ADJ
ajird-1356	177	14	-	-	PUNCT
ajird-1356	177	15	analysis	analysis	NOUN
ajird-1356	177	16	.	.	PUNCT
ajird-1356	178	1	journal	journal	NOUN
ajird-1356	178	2	of	of	ADP
ajird-1356	178	3	infectious	infectious	ADJ
ajird-1356	178	4	diseases	disease	NOUN
ajird-1356	178	5	,	,	PUNCT
ajird-1356	178	6	220(5	220(5	NUM
ajird-1356	178	7	)	)	PUNCT
ajird-1356	178	8	,	,	PUNCT
ajird-1356	178	9	653	653	NUM
ajird-1356	178	10	-	-	SYM
ajird-1356	178	11	662	662	NUM
ajird-1356	178	12	.	.	PUNCT
ajird-1356	179	1	https://doi.org/10.1093/infdis/jiz226	https://doi.org/10.1093/infdis/jiz226	PROPN
ajird-1356	179	2	14	14	NUM
ajird-1356	179	3	.	.	PUNCT
ajird-1356	179	4	butler	butler	PROPN
ajird-1356	179	5	,	,	PUNCT
ajird-1356	179	6	c.	c.	PROPN
ajird-1356	179	7	c.	c.	PROPN
ajird-1356	179	8	,	,	PUNCT
ajird-1356	179	9	&	&	CCONJ
ajird-1356	179	10	duncan	duncan	PROPN
ajird-1356	179	11	,	,	PUNCT
ajird-1356	179	12	m.	m.	NOUN
ajird-1356	179	13	(	(	PUNCT
ajird-1356	179	14	2022	2022	NUM
ajird-1356	179	15	)	)	PUNCT
ajird-1356	179	16	.	.	PUNCT
ajird-1356	180	1	prevalence	prevalence	NOUN
ajird-1356	180	2	of	of	ADP
ajird-1356	180	3	reactive	reactive	ADJ
ajird-1356	180	4	arthritis	arthritis	NOUN
ajird-1356	180	5	following	follow	VERB
ajird-1356	180	6	gastrointestinal	gastrointestinal	ADJ
ajird-1356	180	7	infections	infection	NOUN
ajird-1356	180	8	:	:	PUNCT
ajird-1356	180	9	a	a	DET
ajird-1356	180	10	cohort	cohort	NOUN
ajird-1356	180	11	study	study	NOUN
ajird-1356	180	12	.	.	PUNCT
ajird-1356	181	1	annals	annal	NOUN
ajird-1356	181	2	of	of	ADP
ajird-1356	181	3	the	the	DET
ajird-1356	181	4	rheumatic	rheumatic	ADJ
ajird-1356	181	5	diseases	disease	NOUN
ajird-1356	181	6	,	,	PUNCT
ajird-1356	181	7	81(3	81(3	NUM
ajird-1356	181	8	)	)	PUNCT
ajird-1356	181	9	,	,	PUNCT
ajird-1356	181	10	393	393	NUM
ajird-1356	181	11	-	-	SYM
ajird-1356	181	12	400	400	NUM
ajird-1356	181	13	.	.	PUNCT
ajird-1356	182	1	https://doi.org/10.1136/annrheumdis-2021-220315	https://doi.org/10.1136/annrheumdis-2021-220315	PROPN
ajird-1356	182	2	15	15	NUM
ajird-1356	182	3	.	.	PUNCT
ajird-1356	182	4	gaponoff	gaponoff	NOUN
ajird-1356	182	5	,	,	PUNCT
ajird-1356	182	6	p.	p.	PROPN
ajird-1356	182	7	n.	n.	NOUN
ajird-1356	182	8	,	,	PUNCT
ajird-1356	182	9	&	&	CCONJ
ajird-1356	182	10	singh	singh	PROPN
ajird-1356	182	11	,	,	PUNCT
ajird-1356	182	12	j.	j.	PROPN
ajird-1356	182	13	a.	a.	PROPN
ajird-1356	182	14	(	(	PUNCT
ajird-1356	182	15	2021	2021	NUM
ajird-1356	182	16	)	)	PUNCT
ajird-1356	182	17	.	.	PUNCT
ajird-1356	183	1	treatment	treatment	NOUN
ajird-1356	183	2	efficacy	efficacy	NOUN
ajird-1356	183	3	and	and	CCONJ
ajird-1356	183	4	safety	safety	NOUN
ajird-1356	183	5	in	in	ADP
ajird-1356	183	6	reactive	reactive	ADJ
ajird-1356	183	7	arthritis	arthritis	NOUN
ajird-1356	183	8	:	:	PUNCT
ajird-1356	183	9	a	a	DET
ajird-1356	183	10	systematic	systematic	ADJ
ajird-1356	183	11	review	review	NOUN
ajird-1356	183	12	of	of	ADP
ajird-1356	183	13	biologic	biologic	NOUN
ajird-1356	183	14	agents	agent	NOUN
ajird-1356	183	15	.	.	PUNCT
ajird-1356	184	1	journal	journal	NOUN
ajird-1356	184	2	of	of	ADP
ajird-1356	184	3	rheumatology	rheumatology	NOUN
ajird-1356	184	4	,	,	PUNCT
ajird-1356	184	5	48(2	48(2	NUM
ajird-1356	184	6	)	)	PUNCT
ajird-1356	184	7	,	,	PUNCT
ajird-1356	184	8	285	285	NUM
ajird-1356	184	9	-	-	SYM
ajird-1356	184	10	293	293	NUM
ajird-1356	184	11	.	.	PUNCT
ajird-1356	185	1	https://doi.org/10.3899/jrheum.200324	https://doi.org/10.3899/jrheum.200324	PROPN
ajird-1356	185	2	16	16	NUM
ajird-1356	185	3	.	.	PUNCT
ajird-1356	185	4	gracey	gracey	PROPN
ajird-1356	185	5	,	,	PUNCT
ajird-1356	185	6	e.	e.	PROPN
ajird-1356	185	7	,	,	PUNCT
ajird-1356	185	8	&	&	CCONJ
ajird-1356	185	9	smith	smith	PROPN
ajird-1356	185	10	,	,	PUNCT
ajird-1356	185	11	m.	m.	NOUN
ajird-1356	185	12	(	(	PUNCT
ajird-1356	185	13	2020	2020	NUM
ajird-1356	185	14	)	)	PUNCT
ajird-1356	185	15	.	.	PUNCT
ajird-1356	186	1	jak	jak	PROPN
ajird-1356	186	2	inhibitors	inhibitor	NOUN
ajird-1356	186	3	in	in	ADP
ajird-1356	186	4	the	the	DET
ajird-1356	186	5	treatment	treatment	NOUN
ajird-1356	186	6	of	of	ADP
ajird-1356	186	7	refractory	refractory	NOUN
ajird-1356	186	8	reactive	reactive	ADJ
ajird-1356	186	9	arthritis	arthritis	NOUN
ajird-1356	186	10	:	:	PUNCT
ajird-1356	186	11	a	a	DET
ajird-1356	186	12	new	new	ADJ
ajird-1356	186	13	approach	approach	NOUN
ajird-1356	186	14	.	.	PUNCT
ajird-1356	187	1	frontiers	frontier	NOUN
ajird-1356	187	2	in	in	ADP
ajird-1356	187	3	medicine	medicine	NOUN
ajird-1356	187	4	,	,	PUNCT
ajird-1356	187	5	7	7	NUM
ajird-1356	187	6	,	,	PUNCT
ajird-1356	187	7	581927	581927	NUM
ajird-1356	187	8	.	.	PUNCT
ajird-1356	188	1	https://doi.org/10.3389/fmed.2020.581927	https://doi.org/10.3389/fmed.2020.581927	PROPN
ajird-1356	188	2	17	17	NUM
ajird-1356	188	3	.	.	PUNCT
ajird-1356	189	1	grijalva	grijalva	PROPN
ajird-1356	189	2	,	,	PUNCT
ajird-1356	189	3	c.	c.	PROPN
ajird-1356	189	4	g.	g.	PROPN
ajird-1356	189	5	,	,	PUNCT
ajird-1356	189	6	&	&	CCONJ
ajird-1356	189	7	karczewski	karczewski	PROPN
ajird-1356	189	8	,	,	PUNCT
ajird-1356	189	9	m.	m.	NOUN
ajird-1356	189	10	(	(	PUNCT
ajird-1356	189	11	2023	2023	NUM
ajird-1356	189	12	)	)	PUNCT
ajird-1356	189	13	.	.	PUNCT
ajird-1356	190	1	the	the	DET
ajird-1356	190	2	role	role	NOUN
ajird-1356	190	3	of	of	ADP
ajird-1356	190	4	antibiotics	antibiotic	NOUN
ajird-1356	190	5	in	in	ADP
ajird-1356	190	6	preventing	prevent	VERB
ajird-1356	190	7	reactive	reactive	ADJ
ajird-1356	190	8	arthritis	arthritis	NOUN
ajird-1356	190	9	following	follow	VERB
ajird-1356	190	10	chlamydia	chlamydia	NOUN
ajird-1356	190	11	infections	infection	NOUN
ajird-1356	190	12	:	:	PUNCT
ajird-1356	190	13	a	a	DET
ajird-1356	190	14	randomized	randomized	ADJ
ajird-1356	190	15	controlled	control	VERB
ajird-1356	190	16	trial	trial	NOUN
ajird-1356	190	17	.	.	PUNCT
ajird-1356	191	1	clinical	clinical	ADJ
ajird-1356	191	2	infectious	infectious	ADJ
ajird-1356	191	3	diseases	disease	NOUN
ajird-1356	191	4	,	,	PUNCT
ajird-1356	191	5	76(7	76(7	NOUN
ajird-1356	191	6	)	)	PUNCT
ajird-1356	191	7	,	,	PUNCT
ajird-1356	191	8	1234	1234	NUM
ajird-1356	191	9	-	-	SYM
ajird-1356	191	10	1241	1241	NUM
ajird-1356	191	11	.	.	PUNCT
ajird-1356	192	1	https://doi.org/10.1093/cid/ciad045	https://doi.org/10.1093/cid/ciad045	PROPN
ajird-1356	192	2	.	.	PUNCT
ajird-1356	193	1	https://doi.org/10.1016/j.idc.2017.01.002	https://doi.org/10.1016/j.idc.2017.01.002	PROPN
ajird-1356	193	2	https://doi.org/10.1093/rheumatology/keab118	https://doi.org/10.1093/rheumatology/keab118	X
ajird-1356	194	1	https://doi.org/10.1093/infdis/jiz226	https://doi.org/10.1093/infdis/jiz226	PROPN
ajird-1356	194	2	https://doi.org/10.1136/annrheumdis-2021-220315	https://doi.org/10.1136/annrheumdis-2021-220315	PROPN
ajird-1356	194	3	https://doi.org/10.3899/jrheum.200324	https://doi.org/10.3899/jrheum.200324	NOUN
ajird-1356	195	1	https://doi.org/10.3389/fmed.2020.581927	https://doi.org/10.3389/fmed.2020.581927	PROPN
ajird-1356	195	2	https://doi.org/10.1093/cid/ciad045	https://doi.org/10.1093/cid/ciad045	NOUN