American Journal of Interdisciplinary Research and Development ISSN Online: 2771-8948 Website: www.ajird.journalspark.org Volume 28, May - 2024 156 | P a g e PATHOLOGICAL ANATOMY OF BLOOD VESSELS OF PLACENTAL TISSUE OF PREGNANT WOMEN IN CORONAVIRUS INFECTION Abdulloev Shakhboz Hamroevich Graduate student of the Department of Pathological Anatomy of the Tashkent Medical Academy Babaev Khamza Hurmatovich Associate Professor of Pathological Anatomy Department of Tashkent Medical Academy Omonov Shohruh Rakhimovich Assistant of the Department of Pathological Anatomy of the Tashkent Medical Academy Abstract: This article aims to explore the complex landscape of placental vascular pathology in the setting of maternal COVID-19 infection, and to highlight the challenges and opportunities for clinicians, researchers, and health professionals in protecting pregnant women and their well-being. Keywords: coronavirus, pathological anatomy, blood vessels, placental tissue, placenta. Introduction The coronavirus disease 2019 (COVID-19) pandemic caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus continues to have far-reaching global health implications. Among the various populations affected by this infectious disease, pregnant women stand out as a group that requires special attention and care.[1] MATERIALS AND METHODS Pregnancy involves complex physiological adaptations that may affect the immune and cardiovascular systems, which may alter the course of viral infections. Understanding the interaction between the virus and the placenta in the context of COVID-19 is very is important. The placenta serves as an important connection between the mother and the developing fetus, facilitating the exchange of nutrients, oxygen and waste. Any disturbance in the structure and function of the placenta can have serious consequences for the health of the mother and the development of the fetus. Pregnant women infected with COVID-19 have a variety of clinical symptoms, ranging from mild or asymptomatic infection to severe American Journal of Interdisciplinary Research and Development ISSN Online: 2771-8948 Website: www.ajird.journalspark.org Volume 28, May - 2024 157 | P a g e respiratory failure and multiorgan dysfunction can experience the results. The effect of SARS-CoV-2 on the health of the placenta, and in particular on the blood vessels within the placental tissue, remains the subject of active research and investigation identified characteristic forms, including endothelial damage, inflammation and thrombotic microangiopathy. These data suggest that the virus may directly or indirectly affect the delicate balance of the placental vascular bed, with potential implications for maternal and fetal health. In this regard, studying the pathological anatomy of placental blood vessels in pregnant women with coronavirus infection is very important to gain an understanding of the mechanisms that cause placental dysfunction and adverse pregnancy outcomes. [2] RESULTS AND DISCUSSIONS. By elucidating cellular and molecular changes within the placental vasculature, we can work to improve risk stratification, clinical management, and outcomes for pregnant women exposed to COVID-19. Coronavirus disease 2019 (COVID-19), a novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused serious problems worldwide. Pregnant women are a vulnerable population, and understanding the impact of COVID-19 on pregnancy outcomes is critical. The placenta plays an important role in supporting the development of the fetus, and changes in the blood vessels of the placenta can have serious consequences for the mother and the baby. [3] This article examines the pathological anatomy of placental blood vessels in pregnant women infected with COVID-19. Pregnant women are at increased risk of developing severe disease from respiratory infections due to changes in the immune and cardiovascular systems. The interaction between SARS-CoV-2 and the placenta is relatively understudied, but emerging evidence suggests potential implications for placental health and fetal well- being. Studies have shown that COVID-19 can cause vascular dysfunction and endothelial damage in various organs. In pregnant women, placental blood vessels are particularly sensitive to these effects, given their role in the exchange of nutrients and oxygen between mother and fetus. Histological analysis of placental tissue from pregnant women positive for COVID-19 revealed significant changes in the morphology and function of blood vessels. The presence of vascular anomalies in the placenta of pregnant women infected with COVID-19 is associated with adverse pregnancy outcomes, including preterm birth, fetal growth restriction, and can cause placental insufficiency. Understanding the specific changes in placental vasculature is critical for predicting and managing complications in affected pregnancies. Healthcare providers should be alert for signs of placental vascular dysfunction in pregnant women with COVID-19. Close monitoring through imaging techniques and biomarker assessment can help detect complications early. Further research is needed to elucidate the underlying mechanisms of placental vascular pathology during coronavirus infection and to explore potential therapeutic interventions to mitigate adverse outcomes.[5] American Journal of Interdisciplinary Research and Development ISSN Online: 2771-8948 Website: www.ajird.journalspark.org Volume 28, May - 2024 158 | P a g e CONCLUSION In conclusion, the pathologic anatomy of placental vasculature in pregnant women with COVID-19 represents a complex area of research with important clinical implications. By identifying vascular changes associated with coronavirus infection, we may improve our understanding of how the virus affects pregnancy and develop strategies to optimize maternal and fetal health.[4] REFERENCES 1.Акушерство: нatsiональное руководство / Под ред Э.К. Айламазяна, В.И. Кулакова, В.Е. Радзинского, Г.М. Савельевой. – М.: ГЭОТАР – Медиа, 2007. [1] 2.Анчева И.А. Инструменты скрининга для выявления латент- ногожелезодефицита у беременных. / И.А. Анчева // Современная медицина: актуальные вопросы. — 2013. — № 22. — С. 6-10. [2] 3.Анчева И.А. Комплексная прегравидарная подготовка женщин с дефицитом железа. Акушерство. Гинекология. Эндокринология (86) январь 2015 г. Практическая Медицина стр. 41 [3] 4.Апресян С.В. Беременность и роды при экстрагенитальных заболеваниях. – М., 2009. [4] 5.Бабажанова Ш.Д. Современные подходы при анализе материнской смертности в Узбекистане. XIII Международный конгресс по Репродуктивной медицине. Москва. 21-24 января 2019г. С. 7-9. [5].