id	sid	tid	token	lemma	pos
ajlsi-2730	1	1	pa	pa	PROPN
ajlsi-2730	1	2	ge	ge	PROPN
ajlsi-2730	1	3	1	1	NUM
ajlsi-2730	1	4	pa	pa	PROPN
ajlsi-2730	1	5	ge	ge	PROPN
ajlsi-2730	1	6	69	69	NUM
ajlsi-2730	1	7	american	american	ADJ
ajlsi-2730	1	8	journal	journal	PROPN
ajlsi-2730	1	9	of	of	ADP
ajlsi-2730	1	10	life	life	NOUN
ajlsi-2730	1	11	science	science	NOUN
ajlsi-2730	1	12	and	and	CCONJ
ajlsi-2730	1	13	innovation	innovation	NOUN
ajlsi-2730	1	14	(	(	PUNCT
ajlsi-2730	1	15	ajlsi	ajlsi	NOUN
ajlsi-2730	1	16	)	)	PUNCT
ajlsi-2730	1	17	advancements	advancement	NOUN
ajlsi-2730	1	18	in	in	ADP
ajlsi-2730	1	19	ichthyosis	ichthyosis	NOUN
ajlsi-2730	1	20	treatment	treatment	NOUN
ajlsi-2730	1	21	in	in	ADP
ajlsi-2730	1	22	pediatric	pediatric	ADJ
ajlsi-2730	1	23	patients	patient	NOUN
ajlsi-2730	1	24	:	:	PUNCT
ajlsi-2730	1	25	evaluating	evaluate	VERB
ajlsi-2730	1	26	the	the	DET
ajlsi-2730	1	27	impact	impact	NOUN
ajlsi-2730	1	28	of	of	ADP
ajlsi-2730	1	29	immune	immune	ADJ
ajlsi-2730	1	30	system	system	NOUN
ajlsi-2730	1	31	inhibitors	inhibitor	NOUN
ajlsi-2730	1	32	targeting	target	VERB
ajlsi-2730	1	33	tnf	tnf	PROPN
ajlsi-2730	1	34	-	-	PUNCT
ajlsi-2730	1	35	alpha	alpha	NOUN
ajlsi-2730	1	36	,	,	PUNCT
ajlsi-2730	1	37	il-17a	il-17a	PROPN
ajlsi-2730	1	38	,	,	PUNCT
ajlsi-2730	1	39	il-4	il-4	X
ajlsi-2730	1	40	,	,	PUNCT
ajlsi-2730	1	41	and	and	CCONJ
ajlsi-2730	1	42	il-12	il-12	PRON
ajlsi-2730	1	43	eiman	eiman	PROPN
ajlsi-2730	1	44	hamza	hamza	PROPN
ajlsi-2730	1	45	ahmed	ahmed	PROPN
ajlsi-2730	1	46	elsayed1	elsayed1	PROPN
ajlsi-2730	1	47	*	*	PROPN
ajlsi-2730	1	48	,	,	PUNCT
ajlsi-2730	1	49	rabab	rabab	PROPN
ajlsi-2730	1	50	elsayed	elsaye	VERB
ajlsi-2730	1	51	ali	ali	PROPN
ajlsi-2730	1	52	hassan	hassan	PROPN
ajlsi-2730	1	53	khater2	khater2	PROPN
ajlsi-2730	1	54	volume	volume	NOUN
ajlsi-2730	1	55	3	3	NUM
ajlsi-2730	1	56	issue	issue	NOUN
ajlsi-2730	1	57	1	1	NUM
ajlsi-2730	1	58	,	,	PUNCT
ajlsi-2730	1	59	year	year	NOUN
ajlsi-2730	1	60	2024	2024	NUM
ajlsi-2730	1	61	issn	issn	X
ajlsi-2730	1	62	:	:	PUNCT
ajlsi-2730	1	63	2833	2833	NUM
ajlsi-2730	1	64	-	-	SYM
ajlsi-2730	1	65	1397	1397	NUM
ajlsi-2730	1	66	(	(	PUNCT
ajlsi-2730	1	67	online	online	ADJ
ajlsi-2730	1	68	)	)	PUNCT
ajlsi-2730	1	69	doi	doi	NOUN
ajlsi-2730	1	70	:	:	PUNCT
ajlsi-2730	1	71	https://doi.org/10.54536/ajlsi.v3i1.2730	https://doi.org/10.54536/ajlsi.v3i1.2730	PROPN
ajlsi-2730	1	72	https://journals.e-palli.com/home/index.php/ajlsi	https://journals.e-palli.com/home/index.php/ajlsi	PROPN
ajlsi-2730	1	73	article	article	NOUN
ajlsi-2730	1	74	information	information	NOUN
ajlsi-2730	1	75	abstract	abstract	ADV
ajlsi-2730	1	76	received	receive	VERB
ajlsi-2730	1	77	:	:	PUNCT
ajlsi-2730	1	78	may	may	AUX
ajlsi-2730	1	79	01	01	NUM
ajlsi-2730	1	80	,	,	PUNCT
ajlsi-2730	1	81	2024	2024	NUM
ajlsi-2730	1	82	accepted	accept	VERB
ajlsi-2730	1	83	:	:	PUNCT
ajlsi-2730	1	84	may	may	AUX
ajlsi-2730	1	85	31	31	NUM
ajlsi-2730	1	86	,	,	PUNCT
ajlsi-2730	1	87	2024	2024	NUM
ajlsi-2730	1	88	published	publish	VERB
ajlsi-2730	1	89	:	:	PUNCT
ajlsi-2730	1	90	june	june	PROPN
ajlsi-2730	1	91	04	04	NUM
ajlsi-2730	1	92	,	,	PUNCT
ajlsi-2730	1	93	2024	2024	NUM
ajlsi-2730	1	94	lamellar	lamellar	NOUN
ajlsi-2730	1	95	,	,	PUNCT
ajlsi-2730	1	96	x	x	ADJ
ajlsi-2730	1	97	-	-	VERB
ajlsi-2730	1	98	linked	link	VERB
ajlsi-2730	1	99	recessive	recessive	ADJ
ajlsi-2730	1	100	,	,	PUNCT
ajlsi-2730	1	101	and	and	CCONJ
ajlsi-2730	1	102	vulgaris	vulgaris	NOUN
ajlsi-2730	1	103	ichthyosis	ichthyosis	NOUN
ajlsi-2730	1	104	represent	represent	VERB
ajlsi-2730	1	105	rare	rare	ADJ
ajlsi-2730	1	106	genetic	genetic	ADJ
ajlsi-2730	1	107	variants	variant	NOUN
ajlsi-2730	1	108	distinguished	distinguish	VERB
ajlsi-2730	1	109	by	by	ADP
ajlsi-2730	1	110	abundant	abundant	ADJ
ajlsi-2730	1	111	dry	dry	ADJ
ajlsi-2730	1	112	surface	surface	NOUN
ajlsi-2730	1	113	scales	scale	NOUN
ajlsi-2730	1	114	.	.	PUNCT
ajlsi-2730	2	1	the	the	DET
ajlsi-2730	2	2	etiology	etiology	NOUN
ajlsi-2730	2	3	of	of	ADP
ajlsi-2730	2	4	childhood	childhood	NOUN
ajlsi-2730	2	5	ichthyosis	ichthyosis	NOUN
ajlsi-2730	2	6	involves	involve	VERB
ajlsi-2730	2	7	a	a	DET
ajlsi-2730	2	8	combination	combination	NOUN
ajlsi-2730	2	9	of	of	ADP
ajlsi-2730	2	10	acquired	acquire	VERB
ajlsi-2730	2	11	and	and	CCONJ
ajlsi-2730	2	12	inherited	inherited	ADJ
ajlsi-2730	2	13	factors	factor	NOUN
ajlsi-2730	2	14	.	.	PUNCT
ajlsi-2730	3	1	children	child	NOUN
ajlsi-2730	3	2	with	with	ADP
ajlsi-2730	3	3	ichthyosis	ichthyosis	NOUN
ajlsi-2730	3	4	have	have	VERB
ajlsi-2730	3	5	a	a	DET
ajlsi-2730	3	6	th17dominant	th17dominant	ADJ
ajlsi-2730	3	7	immune	immune	ADJ
ajlsi-2730	3	8	profile	profile	NOUN
ajlsi-2730	3	9	,	,	PUNCT
ajlsi-2730	3	10	similar	similar	ADJ
ajlsi-2730	3	11	to	to	ADP
ajlsi-2730	3	12	psoriasis	psoriasis	NOUN
ajlsi-2730	3	13	,	,	PUNCT
ajlsi-2730	3	14	with	with	ADP
ajlsi-2730	3	15	a	a	DET
ajlsi-2730	3	16	correlation	correlation	NOUN
ajlsi-2730	3	17	between	between	ADP
ajlsi-2730	3	18	ichthyosis	ichthyosis	NOUN
ajlsi-2730	3	19	severity	severity	NOUN
ajlsi-2730	3	20	,	,	PUNCT
ajlsi-2730	3	21	erythema	erythema	ADV
ajlsi-2730	3	22	,	,	PUNCT
ajlsi-2730	3	23	trans	trans	X
ajlsi-2730	3	24	epidermal	epidermal	ADJ
ajlsi-2730	3	25	water	water	NOUN
ajlsi-2730	3	26	loss	loss	NOUN
ajlsi-2730	3	27	(	(	PUNCT
ajlsi-2730	3	28	tewl	tewl	NOUN
ajlsi-2730	3	29	)	)	PUNCT
ajlsi-2730	3	30	,	,	PUNCT
ajlsi-2730	3	31	and	and	CCONJ
ajlsi-2730	3	32	immunological	immunological	ADJ
ajlsi-2730	3	33	markers	marker	NOUN
ajlsi-2730	3	34	.	.	PUNCT
ajlsi-2730	4	1	in	in	ADP
ajlsi-2730	4	2	order	order	NOUN
ajlsi-2730	4	3	to	to	PART
ajlsi-2730	4	4	examine	examine	VERB
ajlsi-2730	4	5	the	the	DET
ajlsi-2730	4	6	safety	safety	NOUN
ajlsi-2730	4	7	and	and	CCONJ
ajlsi-2730	4	8	effectiveness	effectiveness	NOUN
ajlsi-2730	4	9	of	of	ADP
ajlsi-2730	4	10	immune	immune	ADJ
ajlsi-2730	4	11	system	system	NOUN
ajlsi-2730	4	12	inhibitors	inhibitor	NOUN
ajlsi-2730	4	13	that	that	PRON
ajlsi-2730	4	14	target	target	VERB
ajlsi-2730	4	15	tnf	tnf	PROPN
ajlsi-2730	4	16	-	-	PUNCT
ajlsi-2730	4	17	alpha	alpha	NOUN
ajlsi-2730	4	18	,	,	PUNCT
ajlsi-2730	4	19	il-17a	il-17a	PROPN
ajlsi-2730	4	20	,	,	PUNCT
ajlsi-2730	4	21	il-4	il-4	X
ajlsi-2730	4	22	,	,	PUNCT
ajlsi-2730	4	23	and	and	CCONJ
ajlsi-2730	4	24	il-12	il-12	NOUN
ajlsi-2730	4	25	in	in	ADP
ajlsi-2730	4	26	the	the	DET
ajlsi-2730	4	27	treatment	treatment	NOUN
ajlsi-2730	4	28	of	of	ADP
ajlsi-2730	4	29	pediatric	pediatric	ADJ
ajlsi-2730	4	30	ichthyosis	ichthyosis	NOUN
ajlsi-2730	4	31	,	,	PUNCT
ajlsi-2730	4	32	a	a	DET
ajlsi-2730	4	33	retrospective	retrospective	ADJ
ajlsi-2730	4	34	research	research	NOUN
ajlsi-2730	4	35	study	study	NOUN
ajlsi-2730	4	36	was	be	AUX
ajlsi-2730	4	37	conducted	conduct	VERB
ajlsi-2730	4	38	on	on	ADP
ajlsi-2730	4	39	30	30	NUM
ajlsi-2730	4	40	pediatric	pediatric	ADJ
ajlsi-2730	4	41	patients	patient	NOUN
ajlsi-2730	4	42	aged	age	VERB
ajlsi-2730	4	43	6	6	NUM
ajlsi-2730	4	44	-	-	SYM
ajlsi-2730	4	45	12	12	NUM
ajlsi-2730	4	46	years	year	NOUN
ajlsi-2730	4	47	at	at	ADP
ajlsi-2730	4	48	tertiary	tertiary	ADJ
ajlsi-2730	4	49	care	care	NOUN
ajlsi-2730	4	50	pediatric	pediatric	ADJ
ajlsi-2730	4	51	dermatology	dermatology	NOUN
ajlsi-2730	4	52	hospitals	hospital	NOUN
ajlsi-2730	4	53	in	in	ADP
ajlsi-2730	4	54	uae	uae	PROPN
ajlsi-2730	4	55	,	,	PUNCT
ajlsi-2730	4	56	for	for	ADP
ajlsi-2730	4	57	a	a	DET
ajlsi-2730	4	58	time	time	NOUN
ajlsi-2730	4	59	duration	duration	NOUN
ajlsi-2730	4	60	of	of	ADP
ajlsi-2730	4	61	5	5	NUM
ajlsi-2730	4	62	months	month	NOUN
ajlsi-2730	4	63	.	.	PUNCT
ajlsi-2730	5	1	il-17	il-17	NOUN
ajlsi-2730	5	2	-	-	PUNCT
ajlsi-2730	5	3	a	a	PRON
ajlsi-2730	5	4	is	be	AUX
ajlsi-2730	5	5	a	a	DET
ajlsi-2730	5	6	key	key	ADJ
ajlsi-2730	5	7	cytokine	cytokine	NOUN
ajlsi-2730	5	8	of	of	ADP
ajlsi-2730	5	9	ichthyosis	ichthyosis	NOUN
ajlsi-2730	5	10	,	,	PUNCT
ajlsi-2730	5	11	and	and	CCONJ
ajlsi-2730	5	12	its	its	PRON
ajlsi-2730	5	13	specific	specific	ADJ
ajlsi-2730	5	14	suppression	suppression	NOUN
ajlsi-2730	5	15	is	be	AUX
ajlsi-2730	5	16	considered	consider	VERB
ajlsi-2730	5	17	necessary	necessary	ADJ
ajlsi-2730	5	18	in	in	ADP
ajlsi-2730	5	19	contrast	contrast	NOUN
ajlsi-2730	5	20	to	to	ADP
ajlsi-2730	5	21	other	other	ADJ
ajlsi-2730	5	22	cytokines	cytokine	NOUN
ajlsi-2730	5	23	.	.	PUNCT
ajlsi-2730	6	1	consequently	consequently	ADV
ajlsi-2730	6	2	,	,	PUNCT
ajlsi-2730	6	3	the	the	DET
ajlsi-2730	6	4	choice	choice	NOUN
ajlsi-2730	6	5	of	of	ADP
ajlsi-2730	6	6	treatment	treatment	NOUN
ajlsi-2730	6	7	was	be	AUX
ajlsi-2730	6	8	dictated	dictate	VERB
ajlsi-2730	6	9	by	by	ADP
ajlsi-2730	6	10	elements	element	NOUN
ajlsi-2730	6	11	unique	unique	ADJ
ajlsi-2730	6	12	to	to	ADP
ajlsi-2730	6	13	the	the	DET
ajlsi-2730	6	14	condition	condition	NOUN
ajlsi-2730	6	15	and	and	CCONJ
ajlsi-2730	6	16	the	the	DET
ajlsi-2730	6	17	intensity	intensity	NOUN
ajlsi-2730	6	18	of	of	ADP
ajlsi-2730	6	19	symptoms	symptom	NOUN
ajlsi-2730	6	20	,	,	PUNCT
ajlsi-2730	6	21	focusing	focus	VERB
ajlsi-2730	6	22	on	on	ADP
ajlsi-2730	6	23	using	use	VERB
ajlsi-2730	6	24	secukinumab	secukinumab	NOUN
ajlsi-2730	6	25	as	as	ADP
ajlsi-2730	6	26	an	an	DET
ajlsi-2730	6	27	il-17	il-17	ADV
ajlsi-2730	6	28	-	-	PUNCT
ajlsi-2730	6	29	a	a	DET
ajlsi-2730	6	30	inhibitor	inhibitor	NOUN
ajlsi-2730	6	31	.	.	PUNCT
ajlsi-2730	7	1	the	the	DET
ajlsi-2730	7	2	findings	finding	NOUN
ajlsi-2730	7	3	showed	show	VERB
ajlsi-2730	7	4	that	that	SCONJ
ajlsi-2730	7	5	,	,	PUNCT
ajlsi-2730	7	6	following	follow	VERB
ajlsi-2730	7	7	five	five	NUM
ajlsi-2730	7	8	months	month	NOUN
ajlsi-2730	7	9	of	of	ADP
ajlsi-2730	7	10	treatment	treatment	NOUN
ajlsi-2730	7	11	,	,	PUNCT
ajlsi-2730	7	12	patients	patient	NOUN
ajlsi-2730	7	13	receiving	receive	VERB
ajlsi-2730	7	14	secukinumab	secukinumab	NOUN
ajlsi-2730	7	15	showed	show	VERB
ajlsi-2730	7	16	positive	positive	ADJ
ajlsi-2730	7	17	outcomes	outcome	NOUN
ajlsi-2730	7	18	,	,	PUNCT
ajlsi-2730	7	19	with	with	ADP
ajlsi-2730	7	20	their	their	PRON
ajlsi-2730	7	21	ichthyosis	ichthyosis	NOUN
ajlsi-2730	7	22	area	area	NOUN
ajlsi-2730	7	23	severity	severity	NOUN
ajlsi-2730	7	24	index	index	NOUN
ajlsi-2730	7	25	score	score	NOUN
ajlsi-2730	7	26	declining	decline	VERB
ajlsi-2730	7	27	by	by	ADP
ajlsi-2730	7	28	45	45	NUM
ajlsi-2730	7	29	to	to	PART
ajlsi-2730	7	30	50	50	NUM
ajlsi-2730	7	31	%	%	NOUN
ajlsi-2730	7	32	.	.	PUNCT
ajlsi-2730	8	1	additionally	additionally	ADV
ajlsi-2730	8	2	,	,	PUNCT
ajlsi-2730	8	3	the	the	DET
ajlsi-2730	8	4	proinflammatory	proinflammatory	ADJ
ajlsi-2730	8	5	rate	rate	NOUN
ajlsi-2730	8	6	of	of	ADP
ajlsi-2730	8	7	cytokines	cytokine	NOUN
ajlsi-2730	8	8	was	be	AUX
ajlsi-2730	8	9	significantly	significantly	ADV
ajlsi-2730	8	10	lower	low	ADJ
ajlsi-2730	8	11	in	in	ADP
ajlsi-2730	8	12	this	this	DET
ajlsi-2730	8	13	group	group	NOUN
ajlsi-2730	8	14	of	of	ADP
ajlsi-2730	8	15	patients	patient	NOUN
ajlsi-2730	8	16	compared	compare	VERB
ajlsi-2730	8	17	to	to	ADP
ajlsi-2730	8	18	the	the	DET
ajlsi-2730	8	19	placebo	placebo	NOUN
ajlsi-2730	8	20	-	-	PUNCT
ajlsi-2730	8	21	treated	treat	VERB
ajlsi-2730	8	22	control	control	NOUN
ajlsi-2730	8	23	group	group	NOUN
ajlsi-2730	8	24	.	.	PUNCT
ajlsi-2730	9	1	the	the	DET
ajlsi-2730	9	2	safety	safety	NOUN
ajlsi-2730	9	3	and	and	CCONJ
ajlsi-2730	9	4	efficacy	efficacy	NOUN
ajlsi-2730	9	5	of	of	ADP
ajlsi-2730	9	6	secukinumab	secukinumab	NOUN
ajlsi-2730	9	7	compared	compare	VERB
ajlsi-2730	9	8	to	to	ADP
ajlsi-2730	9	9	ixekizumab	ixekizumab	NOUN
ajlsi-2730	9	10	and	and	CCONJ
ajlsi-2730	9	11	brodalumab	brodalumab	NOUN
ajlsi-2730	9	12	vs	vs	ADP
ajlsi-2730	9	13	placebo	placebo	NOUN
ajlsi-2730	9	14	were	be	AUX
ajlsi-2730	9	15	examined	examine	VERB
ajlsi-2730	9	16	using	use	VERB
ajlsi-2730	9	17	t	t	NOUN
ajlsi-2730	9	18	-	-	PUNCT
ajlsi-2730	9	19	tests	test	NOUN
ajlsi-2730	9	20	,	,	PUNCT
ajlsi-2730	9	21	with	with	ADP
ajlsi-2730	9	22	statistical	statistical	ADJ
ajlsi-2730	9	23	significance	significance	NOUN
ajlsi-2730	9	24	determined	determine	VERB
ajlsi-2730	9	25	at	at	ADP
ajlsi-2730	9	26	p	p	X
ajlsi-2730	9	27	<	<	X
ajlsi-2730	9	28	0.05	0.05	NUM
ajlsi-2730	9	29	.	.	PUNCT
ajlsi-2730	10	1	the	the	DET
ajlsi-2730	10	2	present	present	ADJ
ajlsi-2730	10	3	research	research	NOUN
ajlsi-2730	10	4	study	study	NOUN
ajlsi-2730	10	5	concludes	conclude	VERB
ajlsi-2730	10	6	that	that	SCONJ
ajlsi-2730	10	7	secukinumab	secukinumab	NOUN
ajlsi-2730	10	8	effectively	effectively	ADV
ajlsi-2730	10	9	enhances	enhance	VERB
ajlsi-2730	10	10	skin	skin	NOUN
ajlsi-2730	10	11	texture	texture	NOUN
ajlsi-2730	10	12	and	and	CCONJ
ajlsi-2730	10	13	reduces	reduce	VERB
ajlsi-2730	10	14	scaling	scale	VERB
ajlsi-2730	10	15	severity	severity	NOUN
ajlsi-2730	10	16	in	in	ADP
ajlsi-2730	10	17	ichthyosis	ichthyosis	NOUN
ajlsi-2730	10	18	,	,	PUNCT
ajlsi-2730	10	19	suggesting	suggest	VERB
ajlsi-2730	10	20	clinical	clinical	ADJ
ajlsi-2730	10	21	relevance	relevance	NOUN
ajlsi-2730	10	22	.	.	PUNCT
ajlsi-2730	11	1	the	the	DET
ajlsi-2730	11	2	findings	finding	NOUN
ajlsi-2730	11	3	underscore	underscore	NOUN
ajlsi-2730	11	4	secukinumab	secukinumab	NOUN
ajlsi-2730	11	5	’s	’s	PART
ajlsi-2730	11	6	potential	potential	NOUN
ajlsi-2730	11	7	as	as	ADP
ajlsi-2730	11	8	a	a	DET
ajlsi-2730	11	9	beneficial	beneficial	ADJ
ajlsi-2730	11	10	agent	agent	NOUN
ajlsi-2730	11	11	for	for	ADP
ajlsi-2730	11	12	various	various	ADJ
ajlsi-2730	11	13	ichthyosis	ichthyosis	NOUN
ajlsi-2730	11	14	types	type	NOUN
ajlsi-2730	11	15	,	,	PUNCT
ajlsi-2730	11	16	such	such	ADJ
ajlsi-2730	11	17	as	as	ADP
ajlsi-2730	11	18	lamellar	lamellar	ADJ
ajlsi-2730	11	19	,	,	PUNCT
ajlsi-2730	11	20	x	x	X
ajlsi-2730	11	21	-	-	VERB
ajlsi-2730	11	22	linked	link	VERB
ajlsi-2730	11	23	,	,	PUNCT
ajlsi-2730	11	24	and	and	CCONJ
ajlsi-2730	11	25	vulgaris	vulgaris	NOUN
ajlsi-2730	11	26	.	.	PUNCT
ajlsi-2730	12	1	the	the	DET
ajlsi-2730	12	2	study	study	NOUN
ajlsi-2730	12	3	’s	’s	PART
ajlsi-2730	12	4	comparison	comparison	NOUN
ajlsi-2730	12	5	with	with	ADP
ajlsi-2730	12	6	placebo	placebo	NOUN
ajlsi-2730	12	7	and	and	CCONJ
ajlsi-2730	12	8	other	other	ADJ
ajlsi-2730	12	9	il-17a	il-17a	PROPN
ajlsi-2730	12	10	inhibitors	inhibitor	NOUN
ajlsi-2730	12	11	like	like	ADP
ajlsi-2730	12	12	ixekizumab	ixekizumab	NOUN
ajlsi-2730	12	13	and	and	CCONJ
ajlsi-2730	12	14	brodalumab	brodalumab	NOUN
ajlsi-2730	12	15	provides	provide	VERB
ajlsi-2730	12	16	valuable	valuable	ADJ
ajlsi-2730	12	17	insights	insight	NOUN
ajlsi-2730	12	18	into	into	ADP
ajlsi-2730	12	19	secukinumab	secukinumab	NOUN
ajlsi-2730	12	20	’s	’s	PART
ajlsi-2730	12	21	efficacy	efficacy	NOUN
ajlsi-2730	12	22	and	and	CCONJ
ajlsi-2730	12	23	potential	potential	ADJ
ajlsi-2730	12	24	clinical	clinical	ADJ
ajlsi-2730	12	25	uses	use	NOUN
ajlsi-2730	12	26	.	.	PUNCT
ajlsi-2730	13	1	keywords	keyword	NOUN
ajlsi-2730	13	2	ichthyosis	ichthyosis	VERB
ajlsi-2730	13	3	,	,	PUNCT
ajlsi-2730	13	4	secukinumab	secukinumab	NOUN
ajlsi-2730	13	5	,	,	PUNCT
ajlsi-2730	13	6	pediatrics	pediatric	NOUN
ajlsi-2730	13	7	,	,	PUNCT
ajlsi-2730	13	8	il-17	il-17	NUM
ajlsi-2730	13	9	,	,	PUNCT
ajlsi-2730	13	10	tnf	tnf	PROPN
ajlsi-2730	13	11	-	-	PUNCT
ajlsi-2730	13	12	alpha	alpha	NOUN
ajlsi-2730	13	13	,	,	PUNCT
ajlsi-2730	13	14	il-4	il-4	PROPN
ajlsi-2730	13	15	,	,	PUNCT
ajlsi-2730	13	16	il-12	il-12	PRON
ajlsi-2730	13	17	introduction	introduction	NOUN
ajlsi-2730	13	18	lamellar	lamellar	ADJ
ajlsi-2730	13	19	ichthyosis	ichthyosis	NOUN
ajlsi-2730	13	20	,	,	PUNCT
ajlsi-2730	13	21	x	x	X
ajlsi-2730	13	22	-	-	VERB
ajlsi-2730	13	23	linked	link	VERB
ajlsi-2730	13	24	recessive	recessive	ADJ
ajlsi-2730	13	25	ichthyosis	ichthyosis	NOUN
ajlsi-2730	13	26	,	,	PUNCT
ajlsi-2730	13	27	and	and	CCONJ
ajlsi-2730	13	28	ichthyosis	ichthyosis	NOUN
ajlsi-2730	13	29	vulgaris	vulgaris	NOUN
ajlsi-2730	13	30	are	be	AUX
ajlsi-2730	13	31	among	among	ADP
ajlsi-2730	13	32	the	the	DET
ajlsi-2730	13	33	rare	rare	ADJ
ajlsi-2730	13	34	genetic	genetic	ADJ
ajlsi-2730	13	35	variations	variation	NOUN
ajlsi-2730	13	36	of	of	ADP
ajlsi-2730	13	37	this	this	DET
ajlsi-2730	13	38	rare	rare	ADJ
ajlsi-2730	13	39	skin	skin	NOUN
ajlsi-2730	13	40	illness	illness	NOUN
ajlsi-2730	13	41	characterized	characterize	VERB
ajlsi-2730	13	42	by	by	ADP
ajlsi-2730	13	43	excessively	excessively	ADV
ajlsi-2730	13	44	dry	dry	ADJ
ajlsi-2730	13	45	surface	surface	NOUN
ajlsi-2730	13	46	scales	scale	NOUN
ajlsi-2730	13	47	.	.	PUNCT
ajlsi-2730	14	1	both	both	PRON
ajlsi-2730	14	2	acquired	acquire	VERB
ajlsi-2730	14	3	and	and	CCONJ
ajlsi-2730	14	4	inherited	inherit	VERB
ajlsi-2730	14	5	factors	factor	NOUN
ajlsi-2730	14	6	can	can	AUX
ajlsi-2730	14	7	contribute	contribute	VERB
ajlsi-2730	14	8	to	to	ADP
ajlsi-2730	14	9	the	the	DET
ajlsi-2730	14	10	etiology	etiology	NOUN
ajlsi-2730	14	11	of	of	ADP
ajlsi-2730	14	12	childhood	childhood	NOUN
ajlsi-2730	14	13	ichthyosis	ichthyosis	NOUN
ajlsi-2730	14	14	.	.	PUNCT
ajlsi-2730	15	1	most	most	ADJ
ajlsi-2730	15	2	cases	case	NOUN
ajlsi-2730	15	3	of	of	ADP
ajlsi-2730	15	4	ichthyosis	ichthyosis	NOUN
ajlsi-2730	15	5	are	be	AUX
ajlsi-2730	15	6	caused	cause	VERB
ajlsi-2730	15	7	by	by	ADP
ajlsi-2730	15	8	inherited	inherit	VERB
ajlsi-2730	15	9	ichthyosis	ichthyosis	NOUN
ajlsi-2730	15	10	vulgaris	vulgaris	NOUN
ajlsi-2730	15	11	,	,	PUNCT
ajlsi-2730	15	12	caused	cause	VERB
ajlsi-2730	15	13	by	by	ADP
ajlsi-2730	15	14	an	an	DET
ajlsi-2730	15	15	inherited	inherit	VERB
ajlsi-2730	15	16	gene	gene	NOUN
ajlsi-2730	15	17	from	from	ADP
ajlsi-2730	15	18	one	one	NUM
ajlsi-2730	15	19	or	or	CCONJ
ajlsi-2730	15	20	both	both	DET
ajlsi-2730	15	21	parents	parent	NOUN
ajlsi-2730	15	22	(	(	PUNCT
ajlsi-2730	15	23	pontello	pontello	PROPN
ajlsi-2730	15	24	et	et	PROPN
ajlsi-2730	15	25	al	al	PROPN
ajlsi-2730	15	26	.	.	PROPN
ajlsi-2730	15	27	,	,	PUNCT
ajlsi-2730	15	28	2020	2020	NUM
ajlsi-2730	15	29	)	)	PUNCT
ajlsi-2730	15	30	.	.	PUNCT
ajlsi-2730	16	1	another	another	DET
ajlsi-2730	16	2	potential	potential	ADJ
ajlsi-2730	16	3	cause	cause	NOUN
ajlsi-2730	16	4	could	could	AUX
ajlsi-2730	16	5	be	be	AUX
ajlsi-2730	16	6	a	a	DET
ajlsi-2730	16	7	genetic	genetic	ADJ
ajlsi-2730	16	8	mutation	mutation	NOUN
ajlsi-2730	16	9	that	that	PRON
ajlsi-2730	16	10	transpires	transpire	VERB
ajlsi-2730	16	11	in	in	ADP
ajlsi-2730	16	12	the	the	DET
ajlsi-2730	16	13	womb	womb	NOUN
ajlsi-2730	16	14	,	,	PUNCT
ajlsi-2730	16	15	depriving	deprive	VERB
ajlsi-2730	16	16	the	the	DET
ajlsi-2730	16	17	child	child	NOUN
ajlsi-2730	16	18	’s	’s	PART
ajlsi-2730	16	19	skin	skin	NOUN
ajlsi-2730	16	20	of	of	ADP
ajlsi-2730	16	21	a	a	DET
ajlsi-2730	16	22	vital	vital	ADJ
ajlsi-2730	16	23	protein	protein	NOUN
ajlsi-2730	16	24	known	know	VERB
ajlsi-2730	16	25	as	as	ADP
ajlsi-2730	16	26	filaggrin	filaggrin	NOUN
ajlsi-2730	16	27	.	.	PUNCT
ajlsi-2730	17	1	adults	adult	NOUN
ajlsi-2730	17	2	with	with	ADP
ajlsi-2730	17	3	acquired	acquire	VERB
ajlsi-2730	17	4	ichthyosis	ichthyosis	NOUN
ajlsi-2730	17	5	vulgaris	vulgaris	NOUN
ajlsi-2730	17	6	may	may	AUX
ajlsi-2730	17	7	develop	develop	VERB
ajlsi-2730	17	8	the	the	DET
ajlsi-2730	17	9	condition	condition	NOUN
ajlsi-2730	17	10	as	as	ADP
ajlsi-2730	17	11	a	a	DET
ajlsi-2730	17	12	result	result	NOUN
ajlsi-2730	17	13	of	of	ADP
ajlsi-2730	17	14	many	many	ADJ
ajlsi-2730	17	15	medical	medical	ADJ
ajlsi-2730	17	16	conditions	condition	NOUN
ajlsi-2730	17	17	,	,	PUNCT
ajlsi-2730	17	18	including	include	VERB
ajlsi-2730	17	19	kidney	kidney	NOUN
ajlsi-2730	17	20	failure	failure	NOUN
ajlsi-2730	17	21	,	,	PUNCT
ajlsi-2730	17	22	clofazimine	clofazimine	ADJ
ajlsi-2730	17	23	,	,	PUNCT
ajlsi-2730	17	24	nicotinic	nicotinic	ADJ
ajlsi-2730	17	25	acid	acid	NOUN
ajlsi-2730	17	26	deficiency	deficiency	NOUN
ajlsi-2730	17	27	,	,	PUNCT
ajlsi-2730	17	28	sarcoidosis	sarcoidosis	NOUN
ajlsi-2730	17	29	,	,	PUNCT
ajlsi-2730	17	30	leprosy	leprosy	NOUN
ajlsi-2730	17	31	,	,	PUNCT
ajlsi-2730	17	32	and	and	CCONJ
ajlsi-2730	17	33	hiv	hiv	PROPN
ajlsi-2730	17	34	(	(	PUNCT
ajlsi-2730	17	35	lilly	lilly	PROPN
ajlsi-2730	17	36	&	&	CCONJ
ajlsi-2730	17	37	bunick	bunick	PROPN
ajlsi-2730	17	38	,	,	PUNCT
ajlsi-2730	17	39	2023	2023	NUM
ajlsi-2730	17	40	)	)	PUNCT
ajlsi-2730	17	41	.	.	PUNCT
ajlsi-2730	18	1	children	child	NOUN
ajlsi-2730	18	2	’s	’s	PART
ajlsi-2730	18	3	ichthyosis	ichthyosis	NOUN
ajlsi-2730	18	4	is	be	AUX
ajlsi-2730	18	5	caused	cause	VERB
ajlsi-2730	18	6	by	by	ADP
ajlsi-2730	18	7	epidermal	epidermal	ADJ
ajlsi-2730	18	8	development	development	NOUN
ajlsi-2730	18	9	and	and	CCONJ
ajlsi-2730	18	10	metabolism	metabolism	NOUN
ajlsi-2730	18	11	anomalies	anomaly	NOUN
ajlsi-2730	18	12	,	,	PUNCT
ajlsi-2730	18	13	which	which	PRON
ajlsi-2730	18	14	result	result	VERB
ajlsi-2730	18	15	in	in	ADP
ajlsi-2730	18	16	severe	severe	ADJ
ajlsi-2730	18	17	skin	skin	NOUN
ajlsi-2730	18	18	dryness	dryness	NOUN
ajlsi-2730	18	19	and	and	CCONJ
ajlsi-2730	18	20	scaling	scaling	NOUN
ajlsi-2730	18	21	.	.	PUNCT
ajlsi-2730	19	1	mutations	mutation	NOUN
ajlsi-2730	19	2	in	in	ADP
ajlsi-2730	19	3	particular	particular	ADJ
ajlsi-2730	19	4	genes	gene	NOUN
ajlsi-2730	19	5	involved	involve	VERB
ajlsi-2730	19	6	in	in	ADP
ajlsi-2730	19	7	skin	skin	NOUN
ajlsi-2730	19	8	barrier	barrier	NOUN
ajlsi-2730	19	9	function	function	NOUN
ajlsi-2730	19	10	and	and	CCONJ
ajlsi-2730	19	11	cornification	cornification	NOUN
ajlsi-2730	19	12	result	result	NOUN
ajlsi-2730	19	13	in	in	ADP
ajlsi-2730	19	14	inherited	inherited	ADJ
ajlsi-2730	19	15	forms	form	NOUN
ajlsi-2730	19	16	of	of	ADP
ajlsi-2730	19	17	ichthyosis	ichthyosis	NOUN
ajlsi-2730	19	18	,	,	PUNCT
ajlsi-2730	19	19	such	such	ADJ
ajlsi-2730	19	20	as	as	ADP
ajlsi-2730	19	21	autosomal	autosomal	ADJ
ajlsi-2730	19	22	recessive	recessive	ADJ
ajlsi-2730	19	23	congenital	congenital	ADJ
ajlsi-2730	19	24	ichthyosis	ichthyosis	NOUN
ajlsi-2730	19	25	(	(	PUNCT
ajlsi-2730	19	26	arci	arci	NOUN
ajlsi-2730	19	27	)	)	PUNCT
ajlsi-2730	19	28	and	and	CCONJ
ajlsi-2730	19	29	x	x	X
ajlsi-2730	19	30	-	-	VERB
ajlsi-2730	19	31	linked	link	VERB
ajlsi-2730	19	32	recessive	recessive	ADJ
ajlsi-2730	19	33	ichthyosis	ichthyosis	NOUN
ajlsi-2730	19	34	(	(	PUNCT
ajlsi-2730	19	35	xli	xli	PROPN
ajlsi-2730	19	36	)	)	PUNCT
ajlsi-2730	19	37	.	.	PUNCT
ajlsi-2730	20	1	impaired	impair	VERB
ajlsi-2730	20	2	breakdown	breakdown	NOUN
ajlsi-2730	20	3	of	of	ADP
ajlsi-2730	20	4	cholesterol	cholesterol	NOUN
ajlsi-2730	20	5	sulfate	sulfate	NOUN
ajlsi-2730	20	6	leads	lead	VERB
ajlsi-2730	20	7	to	to	PART
ajlsi-2730	20	8	hyperkeratosis	hyperkeratosis	VERB
ajlsi-2730	20	9	and	and	CCONJ
ajlsi-2730	20	10	generalized	generalized	ADJ
ajlsi-2730	20	11	brown	brown	ADJ
ajlsi-2730	20	12	scales	scale	NOUN
ajlsi-2730	20	13	in	in	ADP
ajlsi-2730	20	14	xli	xli	PROPN
ajlsi-2730	20	15	,	,	PUNCT
ajlsi-2730	20	16	which	which	PRON
ajlsi-2730	20	17	is	be	AUX
ajlsi-2730	20	18	associated	associate	VERB
ajlsi-2730	20	19	with	with	ADP
ajlsi-2730	20	20	mutations	mutation	NOUN
ajlsi-2730	20	21	in	in	ADP
ajlsi-2730	20	22	the	the	DET
ajlsi-2730	20	23	steroid	steroid	NOUN
ajlsi-2730	20	24	sulfatase	sulfatase	NOUN
ajlsi-2730	20	25	(	(	PUNCT
ajlsi-2730	20	26	sts	st	NOUN
ajlsi-2730	20	27	)	)	PUNCT
ajlsi-2730	20	28	gene	gene	NOUN
ajlsi-2730	20	29	.	.	PUNCT
ajlsi-2730	21	1	conversely	conversely	ADV
ajlsi-2730	21	2	,	,	PUNCT
ajlsi-2730	21	3	arci	arci	VERB
ajlsi-2730	21	4	comprises	comprise	VERB
ajlsi-2730	21	5	several	several	ADJ
ajlsi-2730	21	6	subtypes	subtype	NOUN
ajlsi-2730	21	7	,	,	PUNCT
ajlsi-2730	21	8	such	such	ADJ
ajlsi-2730	21	9	as	as	ADP
ajlsi-2730	21	10	congenital	congenital	ADJ
ajlsi-2730	21	11	ichthyosiform	ichthyosiform	NOUN
ajlsi-2730	21	12	erythroderma	erythroderma	NOUN
ajlsi-2730	21	13	(	(	PUNCT
ajlsi-2730	21	14	cie	cie	NOUN
ajlsi-2730	21	15	)	)	PUNCT
ajlsi-2730	21	16	and	and	CCONJ
ajlsi-2730	21	17	lamellar	lamellar	ADJ
ajlsi-2730	21	18	ichthyosis	ichthyosis	NOUN
ajlsi-2730	21	19	(	(	PUNCT
ajlsi-2730	21	20	li	li	NOUN
ajlsi-2730	21	21	)	)	PUNCT
ajlsi-2730	21	22	,	,	PUNCT
ajlsi-2730	21	23	andpresents	andpresent	NOUN
ajlsi-2730	21	24	with	with	ADP
ajlsi-2730	21	25	with	with	ADP
ajlsi-2730	21	26	clinical	clinical	ADJ
ajlsi-2730	21	27	symptoms	symptom	NOUN
ajlsi-2730	21	28	,	,	PUNCT
ajlsi-2730	21	29	including	include	VERB
ajlsi-2730	21	30	rough	rough	ADJ
ajlsi-2730	21	31	scaling	scaling	NOUN
ajlsi-2730	21	32	,	,	PUNCT
ajlsi-2730	21	33	erythroderma	erythroderma	NOUN
ajlsi-2730	21	34	and	and	CCONJ
ajlsi-2730	21	35	collodion	collodion	NOUN
ajlsi-2730	21	36	membrane	membrane	NOUN
ajlsi-2730	21	37	after	after	ADP
ajlsi-2730	21	38	birth	birth	NOUN
ajlsi-2730	21	39	(	(	PUNCT
ajlsi-2730	21	40	joosten	joosten	VERB
ajlsi-2730	21	41	et	et	PROPN
ajlsi-2730	21	42	al	al	PROPN
ajlsi-2730	21	43	.	.	PROPN
ajlsi-2730	21	44	,	,	PUNCT
ajlsi-2730	21	45	2022	2022	NUM
ajlsi-2730	21	46	)	)	PUNCT
ajlsi-2730	21	47	.	.	PUNCT
ajlsi-2730	22	1	skin	skin	NOUN
ajlsi-2730	22	2	cornification	cornification	NOUN
ajlsi-2730	22	3	processes	process	NOUN
ajlsi-2730	22	4	,	,	PUNCT
ajlsi-2730	22	5	such	such	ADJ
ajlsi-2730	22	6	as	as	ADP
ajlsi-2730	22	7	desquamation	desquamation	NOUN
ajlsi-2730	22	8	,	,	PUNCT
ajlsi-2730	22	9	keratin	keratin	NOUN
ajlsi-2730	22	10	synthesis	synthesis	NOUN
ajlsi-2730	22	11	,	,	PUNCT
ajlsi-2730	22	12	cornified	cornifie	VERB
ajlsi-2730	22	13	envelope	envelope	NOUN
ajlsi-2730	22	14	synthesis	synthesis	NOUN
ajlsi-2730	22	15	,	,	PUNCT
ajlsi-2730	22	16	and	and	CCONJ
ajlsi-2730	22	17	stratum	stratum	PROPN
ajlsi-2730	22	18	corneum	corneum	NOUN
ajlsi-2730	22	19	structure	structure	NOUN
ajlsi-2730	22	20	,	,	PUNCT
ajlsi-2730	22	21	are	be	AUX
ajlsi-2730	22	22	disrupted	disrupt	VERB
ajlsi-2730	22	23	in	in	ADP
ajlsi-2730	22	24	ichthyosis	ichthyosis	NOUN
ajlsi-2730	22	25	.	.	PUNCT
ajlsi-2730	23	1	increased	increase	VERB
ajlsi-2730	23	2	transepidermal	transepidermal	ADJ
ajlsi-2730	23	3	water	water	NOUN
ajlsi-2730	23	4	loss	loss	NOUN
ajlsi-2730	23	5	(	(	PUNCT
ajlsi-2730	23	6	tewl	tewl	NOUN
ajlsi-2730	23	7	)	)	PUNCT
ajlsi-2730	23	8	,	,	PUNCT
ajlsi-2730	23	9	a	a	DET
ajlsi-2730	23	10	compromised	compromise	VERB
ajlsi-2730	23	11	skin	skin	NOUN
ajlsi-2730	23	12	barrier	barrier	NOUN
ajlsi-2730	23	13	,	,	PUNCT
ajlsi-2730	23	14	and	and	CCONJ
ajlsi-2730	23	15	altered	alter	VERB
ajlsi-2730	23	16	epidermal	epidermal	ADJ
ajlsi-2730	23	17	differentiation	differentiation	NOUN
ajlsi-2730	23	18	result	result	NOUN
ajlsi-2730	23	19	from	from	ADP
ajlsi-2730	23	20	these	these	DET
ajlsi-2730	23	21	disturbances	disturbance	NOUN
ajlsi-2730	23	22	.	.	PUNCT
ajlsi-2730	24	1	extensive	extensive	ADJ
ajlsi-2730	24	2	skin	skin	NOUN
ajlsi-2730	24	3	scaling	scaling	NOUN
ajlsi-2730	24	4	,	,	PUNCT
ajlsi-2730	24	5	hyperkeratosis	hyperkeratosis	NOUN
ajlsi-2730	24	6	,	,	PUNCT
ajlsi-2730	24	7	and	and	CCONJ
ajlsi-2730	24	8	inflammation	inflammation	NOUN
ajlsi-2730	24	9	are	be	AUX
ajlsi-2730	24	10	the	the	DET
ajlsi-2730	24	11	hallmarks	hallmark	NOUN
ajlsi-2730	24	12	;	;	PUNCT
ajlsi-2730	24	13	erythroderma	erythroderma	NOUN
ajlsi-2730	24	14	frequently	frequently	ADV
ajlsi-2730	24	15	follows	follow	VERB
ajlsi-2730	24	16	.	.	PUNCT
ajlsi-2730	25	1	while	while	SCONJ
ajlsi-2730	25	2	acquired	acquire	VERB
ajlsi-2730	25	3	ichthyosis	ichthyosis	NOUN
ajlsi-2730	25	4	in	in	ADP
ajlsi-2730	25	5	children	child	NOUN
ajlsi-2730	25	6	is	be	AUX
ajlsi-2730	25	7	linked	link	VERB
ajlsi-2730	25	8	to	to	ADP
ajlsi-2730	25	9	underlying	underlie	VERB
ajlsi-2730	25	10	illnesses	illness	NOUN
ajlsi-2730	25	11	or	or	CCONJ
ajlsi-2730	25	12	drugs	drug	NOUN
ajlsi-2730	25	13	that	that	PRON
ajlsi-2730	25	14	disrupt	disrupt	VERB
ajlsi-2730	25	15	the	the	DET
ajlsi-2730	25	16	establishment	establishment	NOUN
ajlsi-2730	25	17	of	of	ADP
ajlsi-2730	25	18	the	the	DET
ajlsi-2730	25	19	skin	skin	NOUN
ajlsi-2730	25	20	barrier	barrier	NOUN
ajlsi-2730	25	21	,	,	PUNCT
ajlsi-2730	25	22	resulting	result	VERB
ajlsi-2730	25	23	in	in	ADP
ajlsi-2730	25	24	fishlike	fishlike	ADJ
ajlsi-2730	25	25	scales	scale	NOUN
ajlsi-2730	25	26	concentrated	concentrate	VERB
ajlsi-2730	25	27	on	on	ADP
ajlsi-2730	25	28	the	the	DET
ajlsi-2730	25	29	extremities	extremity	NOUN
ajlsi-2730	25	30	,	,	PUNCT
ajlsi-2730	25	31	hereditary	hereditary	ADJ
ajlsi-2730	25	32	types	type	NOUN
ajlsi-2730	25	33	such	such	ADJ
ajlsi-2730	25	34	as	as	ADP
ajlsi-2730	25	35	xli	xli	PROPN
ajlsi-2730	25	36	and	and	CCONJ
ajlsi-2730	25	37	arci	arci	VERB
ajlsi-2730	25	38	are	be	AUX
ajlsi-2730	25	39	essentially	essentially	ADV
ajlsi-2730	25	40	genetic	genetic	ADJ
ajlsi-2730	25	41	in	in	ADP
ajlsi-2730	25	42	origin	origin	NOUN
ajlsi-2730	25	43	(	(	PUNCT
ajlsi-2730	25	44	dyer	dyer	NOUN
ajlsi-2730	25	45	et	et	PROPN
ajlsi-2730	25	46	al	al	PROPN
ajlsi-2730	25	47	.	.	PROPN
ajlsi-2730	25	48	,	,	PUNCT
ajlsi-2730	25	49	2013	2013	NUM
ajlsi-2730	25	50	)	)	PUNCT
ajlsi-2730	25	51	.	.	PUNCT
ajlsi-2730	26	1	studies	study	NOUN
ajlsi-2730	26	2	on	on	ADP
ajlsi-2730	26	3	children	child	NOUN
ajlsi-2730	26	4	with	with	ADP
ajlsi-2730	26	5	ichthyosis	ichthyosis	NOUN
ajlsi-2730	26	6	reveal	reveal	VERB
ajlsi-2730	26	7	a	a	DET
ajlsi-2730	26	8	th17dominant	th17dominant	ADJ
ajlsi-2730	26	9	immune	immune	ADJ
ajlsi-2730	26	10	profile	profile	NOUN
ajlsi-2730	26	11	with	with	ADP
ajlsi-2730	26	12	elevated	elevated	ADJ
ajlsi-2730	26	13	expression	expression	NOUN
ajlsi-2730	26	14	of	of	ADP
ajlsi-2730	26	15	il17	il17	PROPN
ajlsi-2730	26	16	/	/	SYM
ajlsi-2730	26	17	tnfα	tnfα	NOUN
ajlsi-2730	26	18	-	-	PUNCT
ajlsi-2730	26	19	synergistic	synergistic	ADJ
ajlsi-2730	26	20	/	/	SYM
ajlsi-2730	26	21	additive	additive	ADJ
ajlsi-2730	26	22	genes	gene	NOUN
ajlsi-2730	26	23	.	.	PUNCT
ajlsi-2730	27	1	this	this	DET
ajlsi-2730	27	2	immunological	immunological	ADJ
ajlsi-2730	27	3	profile	profile	NOUN
ajlsi-2730	27	4	is	be	AUX
ajlsi-2730	27	5	comparable	comparable	ADJ
ajlsi-2730	27	6	to	to	ADP
ajlsi-2730	27	7	that	that	PRON
ajlsi-2730	27	8	of	of	ADP
ajlsi-2730	27	9	the	the	DET
ajlsi-2730	27	10	inflammatory	inflammatory	ADJ
ajlsi-2730	27	11	1	1	NUM
ajlsi-2730	27	12	pediatric	pediatric	ADJ
ajlsi-2730	27	13	specialist	specialist	NOUN
ajlsi-2730	27	14	in	in	ADP
ajlsi-2730	27	15	uae	uae	PROPN
ajlsi-2730	27	16	2	2	NUM
ajlsi-2730	27	17	dermatology	dermatology	NOUN
ajlsi-2730	27	18	specialist	specialist	NOUN
ajlsi-2730	27	19	in	in	ADP
ajlsi-2730	27	20	uae	uae	PROPN
ajlsi-2730	27	21	*	*	PUNCT
ajlsi-2730	27	22	corresponding	correspond	VERB
ajlsi-2730	27	23	author	author	NOUN
ajlsi-2730	27	24	’s	’s	PART
ajlsi-2730	27	25	e	e	NOUN
ajlsi-2730	27	26	-	-	NOUN
ajlsi-2730	27	27	mail	mail	NOUN
ajlsi-2730	27	28	:	:	PUNCT
ajlsi-2730	27	29	dr_eh2412@yahoo.com	dr_eh2412@yahoo.com	X
ajlsi-2730	27	30	pa	pa	PROPN
ajlsi-2730	27	31	ge	ge	PROPN
ajlsi-2730	27	32	70	70	NUM
ajlsi-2730	27	33	https://journals.e-palli.com/home/index.php/ajlsi	https://journals.e-palli.com/home/index.php/ajlsi	PROPN
ajlsi-2730	27	34	am	am	NOUN
ajlsi-2730	27	35	.	.	PUNCT
ajlsi-2730	28	1	j.	j.	PROPN
ajlsi-2730	28	2	life	life	PROPN
ajlsi-2730	28	3	sci	sci	PROPN
ajlsi-2730	28	4	.	.	PUNCT
ajlsi-2730	28	5	innov	innov	PROPN
ajlsi-2730	28	6	.	.	PUNCT
ajlsi-2730	29	1	3(1	3(1	NUM
ajlsi-2730	29	2	)	)	PUNCT
ajlsi-2730	29	3	69	69	NUM
ajlsi-2730	29	4	-	-	SYM
ajlsi-2730	29	5	74	74	NUM
ajlsi-2730	29	6	,	,	PUNCT
ajlsi-2730	29	7	2024	2024	NUM
ajlsi-2730	29	8	condition	condition	NOUN
ajlsi-2730	29	9	psoriasis	psoriasis	NOUN
ajlsi-2730	29	10	.	.	PUNCT
ajlsi-2730	30	1	the	the	DET
ajlsi-2730	30	2	severity	severity	NOUN
ajlsi-2730	30	3	of	of	ADP
ajlsi-2730	30	4	ichthyosis	ichthyosis	NOUN
ajlsi-2730	30	5	,	,	PUNCT
ajlsi-2730	30	6	erythema	erythema	ADV
ajlsi-2730	30	7	,	,	PUNCT
ajlsi-2730	30	8	and	and	CCONJ
ajlsi-2730	30	9	transepidermal	transepidermal	ADJ
ajlsi-2730	30	10	water	water	NOUN
ajlsi-2730	30	11	loss	loss	NOUN
ajlsi-2730	30	12	(	(	PUNCT
ajlsi-2730	30	13	tewl	tewl	NOUN
ajlsi-2730	30	14	)	)	PUNCT
ajlsi-2730	30	15	is	be	AUX
ajlsi-2730	30	16	significantly	significantly	ADV
ajlsi-2730	30	17	linked	link	VERB
ajlsi-2730	30	18	to	to	ADP
ajlsi-2730	30	19	immunological	immunological	ADJ
ajlsi-2730	30	20	markers	marker	NOUN
ajlsi-2730	30	21	,	,	PUNCT
ajlsi-2730	30	22	suggesting	suggest	VERB
ajlsi-2730	30	23	a	a	DET
ajlsi-2730	30	24	potential	potential	ADJ
ajlsi-2730	30	25	link	link	NOUN
ajlsi-2730	30	26	between	between	ADP
ajlsi-2730	30	27	inflammation	inflammation	NOUN
ajlsi-2730	30	28	and	and	CCONJ
ajlsi-2730	30	29	skin	skin	NOUN
ajlsi-2730	30	30	barrier	barrier	NOUN
ajlsi-2730	30	31	abnormalities	abnormality	NOUN
ajlsi-2730	30	32	.	.	PUNCT
ajlsi-2730	31	1	(	(	PUNCT
ajlsi-2730	31	2	czarnowicki	czarnowicki	NOUN
ajlsi-2730	31	3	et	et	PROPN
ajlsi-2730	31	4	al	al	PROPN
ajlsi-2730	31	5	.	.	PROPN
ajlsi-2730	31	6	,	,	PUNCT
ajlsi-2730	31	7	2018	2018	NUM
ajlsi-2730	31	8	;	;	PUNCT
ajlsi-2730	31	9	kim	kim	PROPN
ajlsi-2730	31	10	et	et	PROPN
ajlsi-2730	31	11	al	al	PROPN
ajlsi-2730	31	12	.	.	PROPN
ajlsi-2730	31	13	,	,	PUNCT
ajlsi-2730	31	14	2022	2022	NUM
ajlsi-2730	31	15	;	;	PUNCT
ajlsi-2730	31	16	paller	paller	NOUN
ajlsi-2730	31	17	,	,	PUNCT
ajlsi-2730	31	18	2019	2019	NUM
ajlsi-2730	31	19	)	)	PUNCT
ajlsi-2730	31	20	.	.	PUNCT
ajlsi-2730	32	1	targeting	target	VERB
ajlsi-2730	32	2	tnf	tnf	PROPN
ajlsi-2730	32	3	-	-	PUNCT
ajlsi-2730	32	4	alpha	alpha	NOUN
ajlsi-2730	32	5	,	,	PUNCT
ajlsi-2730	32	6	il-17a	il-17a	PROPN
ajlsi-2730	32	7	,	,	PUNCT
ajlsi-2730	32	8	il-4	il-4	X
ajlsi-2730	32	9	,	,	PUNCT
ajlsi-2730	32	10	and	and	CCONJ
ajlsi-2730	32	11	il-12	il-12	NOUN
ajlsi-2730	32	12	,	,	PUNCT
ajlsi-2730	32	13	immune	immune	ADJ
ajlsi-2730	32	14	system	system	NOUN
ajlsi-2730	32	15	inhibitors	inhibitor	NOUN
ajlsi-2730	32	16	have	have	AUX
ajlsi-2730	32	17	demonstrated	demonstrate	VERB
ajlsi-2730	32	18	potential	potential	NOUN
ajlsi-2730	32	19	in	in	ADP
ajlsi-2730	32	20	treating	treat	VERB
ajlsi-2730	32	21	ichthyosis	ichthyosis	NOUN
ajlsi-2730	32	22	by	by	ADP
ajlsi-2730	32	23	treating	treat	VERB
ajlsi-2730	32	24	immunological	immunological	ADJ
ajlsi-2730	32	25	dysregulation	dysregulation	NOUN
ajlsi-2730	32	26	and	and	CCONJ
ajlsi-2730	32	27	inflammation	inflammation	NOUN
ajlsi-2730	32	28	.	.	PUNCT
ajlsi-2730	33	1	while	while	SCONJ
ajlsi-2730	33	2	il-17a	il-17a	PROPN
ajlsi-2730	33	3	inhibitors	inhibitor	NOUN
ajlsi-2730	33	4	may	may	AUX
ajlsi-2730	33	5	provide	provide	VERB
ajlsi-2730	33	6	a	a	DET
ajlsi-2730	33	7	specific	specific	ADJ
ajlsi-2730	33	8	treatment	treatment	NOUN
ajlsi-2730	33	9	for	for	ADP
ajlsi-2730	33	10	the	the	DET
ajlsi-2730	33	11	pathophysiology	pathophysiology	NOUN
ajlsi-2730	33	12	of	of	ADP
ajlsi-2730	33	13	ichthyosis	ichthyosis	NOUN
ajlsi-2730	33	14	,	,	PUNCT
ajlsi-2730	33	15	tnf	tnf	PROPN
ajlsi-2730	33	16	-	-	PUNCT
ajlsi-2730	33	17	alpha	alpha	NOUN
ajlsi-2730	33	18	inhibitors	inhibitor	NOUN
ajlsi-2730	33	19	have	have	AUX
ajlsi-2730	33	20	been	be	AUX
ajlsi-2730	33	21	shown	show	VERB
ajlsi-2730	33	22	useful	useful	ADJ
ajlsi-2730	33	23	in	in	ADP
ajlsi-2730	33	24	treating	treat	VERB
ajlsi-2730	33	25	inflammatory	inflammatory	ADJ
ajlsi-2730	33	26	skin	skin	NOUN
ajlsi-2730	33	27	conditions	condition	NOUN
ajlsi-2730	33	28	.	.	PUNCT
ajlsi-2730	34	1	moreover	moreover	ADV
ajlsi-2730	34	2	,	,	PUNCT
ajlsi-2730	34	3	inhibitors	inhibitor	NOUN
ajlsi-2730	34	4	that	that	PRON
ajlsi-2730	34	5	target	target	VERB
ajlsi-2730	34	6	il-4	il-4	NOUN
ajlsi-2730	34	7	and	and	CCONJ
ajlsi-2730	34	8	il-12	il-12	NOUN
ajlsi-2730	34	9	appear	appear	VERB
ajlsi-2730	34	10	to	to	PART
ajlsi-2730	34	11	have	have	VERB
ajlsi-2730	34	12	therapeutic	therapeutic	ADJ
ajlsi-2730	34	13	applications	application	NOUN
ajlsi-2730	34	14	(	(	PUNCT
ajlsi-2730	34	15	huangfu	huangfu	X
ajlsi-2730	34	16	et	et	PROPN
ajlsi-2730	34	17	al	al	PROPN
ajlsi-2730	34	18	.	.	PROPN
ajlsi-2730	34	19	,	,	PUNCT
ajlsi-2730	34	20	2023	2023	NUM
ajlsi-2730	34	21	;	;	PUNCT
ajlsi-2730	34	22	paller	paller	NOUN
ajlsi-2730	34	23	,	,	PUNCT
ajlsi-2730	34	24	2019	2019	NUM
ajlsi-2730	34	25	;	;	PUNCT
ajlsi-2730	34	26	wang	wang	PROPN
ajlsi-2730	34	27	et	et	PROPN
ajlsi-2730	34	28	al	al	PROPN
ajlsi-2730	34	29	.	.	PROPN
ajlsi-2730	34	30	,	,	PUNCT
ajlsi-2730	34	31	2021	2021	NUM
ajlsi-2730	34	32	)	)	PUNCT
ajlsi-2730	34	33	.	.	PUNCT
ajlsi-2730	35	1	drugs	drug	NOUN
ajlsi-2730	35	2	that	that	PRON
ajlsi-2730	35	3	inhibit	inhibit	VERB
ajlsi-2730	35	4	factors	factor	NOUN
ajlsi-2730	35	5	related	relate	VERB
ajlsi-2730	35	6	to	to	ADP
ajlsi-2730	35	7	the	the	DET
ajlsi-2730	35	8	immune	immune	ADJ
ajlsi-2730	35	9	system	system	NOUN
ajlsi-2730	35	10	,	,	PUNCT
ajlsi-2730	35	11	such	such	ADJ
ajlsi-2730	35	12	as	as	ADP
ajlsi-2730	35	13	tnf	tnf	PROPN
ajlsi-2730	35	14	-	-	PUNCT
ajlsi-2730	35	15	alpha	alpha	PROPN
ajlsi-2730	35	16	,	,	PUNCT
ajlsi-2730	35	17	il-17a	il-17a	PROPN
ajlsi-2730	35	18	,	,	PUNCT
ajlsi-2730	35	19	il-4	il-4	X
ajlsi-2730	35	20	,	,	PUNCT
ajlsi-2730	35	21	and	and	CCONJ
ajlsi-2730	35	22	il-12	il-12	NOUN
ajlsi-2730	35	23	,	,	PUNCT
ajlsi-2730	35	24	are	be	AUX
ajlsi-2730	35	25	often	often	ADV
ajlsi-2730	35	26	considered	consider	VERB
ajlsi-2730	35	27	as	as	ADP
ajlsi-2730	35	28	potential	potential	ADJ
ajlsi-2730	35	29	treatments	treatment	NOUN
ajlsi-2730	35	30	,	,	PUNCT
ajlsi-2730	35	31	including	include	VERB
ajlsi-2730	35	32	etanercept	etanercept	NOUN
ajlsi-2730	35	33	,	,	PUNCT
ajlsi-2730	35	34	adalimumab	adalimumab	NOUN
ajlsi-2730	35	35	,	,	PUNCT
ajlsi-2730	35	36	infliximab	infliximab	PROPN
ajlsi-2730	35	37	(	(	PUNCT
ajlsi-2730	35	38	tnf	tnf	PROPN
ajlsi-2730	35	39	-	-	PUNCT
ajlsi-2730	35	40	alpha	alpha	NOUN
ajlsi-2730	35	41	inhibitors	inhibitor	NOUN
ajlsi-2730	35	42	)	)	PUNCT
ajlsi-2730	35	43	,	,	PUNCT
ajlsi-2730	35	44	secukinumab	secukinumab	NOUN
ajlsi-2730	35	45	,	,	PUNCT
ajlsi-2730	35	46	ixekizumab	ixekizumab	NOUN
ajlsi-2730	35	47	,	,	PUNCT
ajlsi-2730	35	48	brodalumab	brodalumab	NOUN
ajlsi-2730	35	49	(	(	PUNCT
ajlsi-2730	35	50	il-17a	il-17a	PROPN
ajlsi-2730	35	51	inhibitors	inhibitor	NOUN
ajlsi-2730	35	52	)	)	PUNCT
ajlsi-2730	35	53	,	,	PUNCT
ajlsi-2730	35	54	dupilumab	dupilumab	NOUN
ajlsi-2730	35	55	(	(	PUNCT
ajlsi-2730	35	56	il-4	il-4	NOUN
ajlsi-2730	35	57	inhibitors	inhibitor	NOUN
ajlsi-2730	35	58	)	)	PUNCT
ajlsi-2730	35	59	and	and	CCONJ
ajlsi-2730	35	60	ustekinumab	ustekinumab	NOUN
ajlsi-2730	35	61	(	(	PUNCT
ajlsi-2730	35	62	il12	il12	PROPN
ajlsi-2730	35	63	and	and	CCONJ
ajlsi-2730	35	64	23	23	NUM
ajlsi-2730	35	65	inhibitors	inhibitor	NOUN
ajlsi-2730	35	66	)	)	PUNCT
ajlsi-2730	35	67	(	(	PUNCT
ajlsi-2730	35	68	paller	paller	NOUN
ajlsi-2730	35	69	et	et	NOUN
ajlsi-2730	35	70	al	al	PROPN
ajlsi-2730	35	71	.	.	PROPN
ajlsi-2730	35	72	,	,	PUNCT
ajlsi-2730	35	73	2017	2017	NUM
ajlsi-2730	35	74	;	;	PUNCT
ajlsi-2730	35	75	peña	peña	PROPN
ajlsi-2730	35	76	-	-	PUNCT
ajlsi-2730	35	77	corona	corona	NOUN
ajlsi-2730	35	78	et	et	NOUN
ajlsi-2730	35	79	al	al	PROPN
ajlsi-2730	35	80	.	.	PROPN
ajlsi-2730	35	81	,	,	PUNCT
ajlsi-2730	35	82	2023	2023	NUM
ajlsi-2730	35	83	;	;	PUNCT
ajlsi-2730	35	84	zaenglein	zaenglein	PROPN
ajlsi-2730	35	85	et	et	PROPN
ajlsi-2730	35	86	al	al	PROPN
ajlsi-2730	35	87	.	.	PROPN
ajlsi-2730	35	88	,	,	PUNCT
ajlsi-2730	35	89	2021	2021	NUM
ajlsi-2730	35	90	)	)	PUNCT
ajlsi-2730	35	91	.	.	PUNCT
ajlsi-2730	36	1	the	the	DET
ajlsi-2730	36	2	present	present	ADJ
ajlsi-2730	36	3	research	research	NOUN
ajlsi-2730	36	4	study	study	NOUN
ajlsi-2730	36	5	aimed	aim	VERB
ajlsi-2730	36	6	to	to	PART
ajlsi-2730	36	7	improve	improve	VERB
ajlsi-2730	36	8	the	the	DET
ajlsi-2730	36	9	quality	quality	NOUN
ajlsi-2730	36	10	of	of	ADP
ajlsi-2730	36	11	life	life	NOUN
ajlsi-2730	36	12	by	by	ADP
ajlsi-2730	36	13	examining	examine	VERB
ajlsi-2730	36	14	the	the	DET
ajlsi-2730	36	15	safety	safety	NOUN
ajlsi-2730	36	16	and	and	CCONJ
ajlsi-2730	36	17	efficacy	efficacy	NOUN
ajlsi-2730	36	18	of	of	ADP
ajlsi-2730	36	19	immune	immune	ADJ
ajlsi-2730	36	20	system	system	NOUN
ajlsi-2730	36	21	inhibitors	inhibitor	NOUN
ajlsi-2730	36	22	that	that	PRON
ajlsi-2730	36	23	target	target	VERB
ajlsi-2730	36	24	tnf	tnf	PROPN
ajlsi-2730	36	25	-	-	PUNCT
ajlsi-2730	36	26	alpha	alpha	NOUN
ajlsi-2730	36	27	,	,	PUNCT
ajlsi-2730	36	28	il-17a	il-17a	PROPN
ajlsi-2730	36	29	,	,	PUNCT
ajlsi-2730	36	30	il-4	il-4	X
ajlsi-2730	36	31	,	,	PUNCT
ajlsi-2730	36	32	and	and	CCONJ
ajlsi-2730	36	33	il-12	il-12	NOUN
ajlsi-2730	36	34	in	in	ADP
ajlsi-2730	36	35	pediatric	pediatric	ADJ
ajlsi-2730	36	36	ichthyosis	ichthyosis	NOUN
ajlsi-2730	36	37	treatment	treatment	NOUN
ajlsi-2730	36	38	.	.	PUNCT
ajlsi-2730	37	1	literature	literature	NOUN
ajlsi-2730	37	2	review	review	NOUN
ajlsi-2730	37	3	ichthyosis	ichthyosis	NOUN
ajlsi-2730	37	4	is	be	AUX
ajlsi-2730	37	5	a	a	DET
ajlsi-2730	37	6	common	common	ADJ
ajlsi-2730	37	7	skin	skin	NOUN
ajlsi-2730	37	8	ailment	ailment	NOUN
ajlsi-2730	37	9	that	that	PRON
ajlsi-2730	37	10	impairs	impair	VERB
ajlsi-2730	37	11	perspiration	perspiration	NOUN
ajlsi-2730	37	12	,	,	PUNCT
ajlsi-2730	37	13	causes	cause	VERB
ajlsi-2730	37	14	itching	itching	NOUN
ajlsi-2730	37	15	,	,	PUNCT
ajlsi-2730	37	16	and	and	CCONJ
ajlsi-2730	37	17	causes	cause	VERB
ajlsi-2730	37	18	recurrent	recurrent	ADJ
ajlsi-2730	37	19	infections	infection	NOUN
ajlsi-2730	37	20	.	.	PUNCT
ajlsi-2730	38	1	it	it	PRON
ajlsi-2730	38	2	also	also	ADV
ajlsi-2730	38	3	negatively	negatively	ADV
ajlsi-2730	38	4	affects	affect	VERB
ajlsi-2730	38	5	the	the	DET
ajlsi-2730	38	6	quality	quality	NOUN
ajlsi-2730	38	7	of	of	ADP
ajlsi-2730	38	8	life	life	NOUN
ajlsi-2730	38	9	for	for	ADP
ajlsi-2730	38	10	those	those	PRON
ajlsi-2730	38	11	who	who	PRON
ajlsi-2730	38	12	have	have	VERB
ajlsi-2730	38	13	it	it	PRON
ajlsi-2730	38	14	.	.	PUNCT
ajlsi-2730	39	1	although	although	SCONJ
ajlsi-2730	39	2	diagnosis	diagnosis	NOUN
ajlsi-2730	39	3	is	be	AUX
ajlsi-2730	39	4	hampered	hamper	VERB
ajlsi-2730	39	5	by	by	ADP
ajlsi-2730	39	6	diverse	diverse	ADJ
ajlsi-2730	39	7	clinical	clinical	ADJ
ajlsi-2730	39	8	presentation	presentation	NOUN
ajlsi-2730	39	9	and	and	CCONJ
ajlsi-2730	39	10	inadequate	inadequate	ADJ
ajlsi-2730	39	11	phenotype	phenotype	NOUN
ajlsi-2730	39	12	–	–	PUNCT
ajlsi-2730	39	13	genotype	genotype	NOUN
ajlsi-2730	39	14	association	association	NOUN
ajlsi-2730	39	15	,	,	PUNCT
ajlsi-2730	39	16	the	the	DET
ajlsi-2730	39	17	distinctive	distinctive	ADJ
ajlsi-2730	39	18	clinical	clinical	ADJ
ajlsi-2730	39	19	symptoms	symptom	NOUN
ajlsi-2730	39	20	represent	represent	VERB
ajlsi-2730	39	21	a	a	DET
ajlsi-2730	39	22	homeostatic	homeostatic	ADJ
ajlsi-2730	39	23	attempt	attempt	NOUN
ajlsi-2730	39	24	to	to	PART
ajlsi-2730	39	25	restore	restore	VERB
ajlsi-2730	39	26	the	the	DET
ajlsi-2730	39	27	epidermal	epidermal	ADJ
ajlsi-2730	39	28	barrier	barrier	NOUN
ajlsi-2730	39	29	.	.	PUNCT
ajlsi-2730	40	1	comprehending	comprehend	VERB
ajlsi-2730	40	2	the	the	DET
ajlsi-2730	40	3	molecular	molecular	ADJ
ajlsi-2730	40	4	pathways	pathway	NOUN
ajlsi-2730	40	5	is	be	AUX
ajlsi-2730	40	6	essential	essential	ADJ
ajlsi-2730	40	7	for	for	ADP
ajlsi-2730	40	8	creating	create	VERB
ajlsi-2730	40	9	novel	novel	ADJ
ajlsi-2730	40	10	therapy	therapy	NOUN
ajlsi-2730	40	11	approaches	approach	VERB
ajlsi-2730	40	12	that	that	PRON
ajlsi-2730	40	13	target	target	VERB
ajlsi-2730	40	14	the	the	DET
ajlsi-2730	40	15	underlying	underlie	VERB
ajlsi-2730	40	16	causes	cause	NOUN
ajlsi-2730	40	17	of	of	ADP
ajlsi-2730	40	18	various	various	ADJ
ajlsi-2730	40	19	ailments	ailment	NOUN
ajlsi-2730	40	20	(	(	PUNCT
ajlsi-2730	40	21	gutiérrezcerrajero	gutiérrezcerrajero	NOUN
ajlsi-2730	40	22	et	et	PROPN
ajlsi-2730	40	23	al	al	PROPN
ajlsi-2730	40	24	.	.	PROPN
ajlsi-2730	40	25	,	,	PUNCT
ajlsi-2730	40	26	2023	2023	NUM
ajlsi-2730	40	27	)	)	PUNCT
ajlsi-2730	40	28	.	.	PUNCT
ajlsi-2730	41	1	ichthyoses	ichthyose	NOUN
ajlsi-2730	41	2	and	and	CCONJ
ajlsi-2730	41	3	cornification	cornification	NOUN
ajlsi-2730	41	4	disorders	disorder	NOUN
ajlsi-2730	41	5	often	often	ADV
ajlsi-2730	41	6	require	require	VERB
ajlsi-2730	41	7	longterm	longterm	ADJ
ajlsi-2730	41	8	retinoid	retinoid	PROPN
ajlsi-2730	41	9	treatment	treatment	NOUN
ajlsi-2730	41	10	.	.	PUNCT
ajlsi-2730	42	1	however	however	ADV
ajlsi-2730	42	2	,	,	PUNCT
ajlsi-2730	42	3	it	it	PRON
ajlsi-2730	42	4	was	be	AUX
ajlsi-2730	42	5	found	find	VERB
ajlsi-2730	42	6	that	that	SCONJ
ajlsi-2730	42	7	longterm	longterm	VERB
ajlsi-2730	42	8	use	use	NOUN
ajlsi-2730	42	9	of	of	ADP
ajlsi-2730	42	10	retinoids	retinoid	NOUN
ajlsi-2730	42	11	in	in	ADP
ajlsi-2730	42	12	ichthyoses	ichthyose	NOUN
ajlsi-2730	42	13	may	may	AUX
ajlsi-2730	42	14	cause	cause	VERB
ajlsi-2730	42	15	potential	potential	ADJ
ajlsi-2730	42	16	negative	negative	ADJ
ajlsi-2730	42	17	effects	effect	NOUN
ajlsi-2730	42	18	on	on	ADP
ajlsi-2730	42	19	the	the	DET
ajlsi-2730	42	20	eyes	eye	NOUN
ajlsi-2730	42	21	,	,	PUNCT
ajlsi-2730	42	22	bones	bone	NOUN
ajlsi-2730	42	23	,	,	PUNCT
ajlsi-2730	42	24	heart	heart	NOUN
ajlsi-2730	42	25	,	,	PUNCT
ajlsi-2730	42	26	and	and	CCONJ
ajlsi-2730	42	27	psyche	psyche	NOUN
ajlsi-2730	42	28	,	,	PUNCT
ajlsi-2730	42	29	requiring	require	VERB
ajlsi-2730	42	30	careful	careful	ADJ
ajlsi-2730	42	31	clinical	clinical	ADJ
ajlsi-2730	42	32	considerations	consideration	NOUN
ajlsi-2730	42	33	(	(	PUNCT
ajlsi-2730	42	34	zaenglein	zaenglein	NOUN
ajlsi-2730	42	35	et	et	PROPN
ajlsi-2730	42	36	al	al	PROPN
ajlsi-2730	42	37	.	.	PROPN
ajlsi-2730	42	38	,	,	PUNCT
ajlsi-2730	42	39	2021	2021	NUM
ajlsi-2730	42	40	)	)	PUNCT
ajlsi-2730	42	41	.	.	PUNCT
ajlsi-2730	43	1	based	base	VERB
ajlsi-2730	43	2	on	on	ADP
ajlsi-2730	43	3	the	the	DET
ajlsi-2730	43	4	etiology	etiology	NOUN
ajlsi-2730	43	5	of	of	ADP
ajlsi-2730	43	6	the	the	DET
ajlsi-2730	43	7	skin	skin	NOUN
ajlsi-2730	43	8	disorder	disorder	NOUN
ajlsi-2730	43	9	,	,	PUNCT
ajlsi-2730	43	10	gene	gene	NOUN
ajlsi-2730	43	11	therapy	therapy	NOUN
ajlsi-2730	43	12	,	,	PUNCT
ajlsi-2730	43	13	and	and	CCONJ
ajlsi-2730	43	14	protein	protein	NOUN
ajlsi-2730	43	15	substitution	substitution	NOUN
ajlsi-2730	43	16	are	be	AUX
ajlsi-2730	43	17	used	use	VERB
ajlsi-2730	43	18	as	as	ADP
ajlsi-2730	43	19	treatments	treatment	NOUN
ajlsi-2730	43	20	for	for	ADP
ajlsi-2730	43	21	ichthyosis	ichthyosis	NOUN
ajlsi-2730	43	22	.	.	PUNCT
ajlsi-2730	44	1	it	it	PRON
ajlsi-2730	44	2	was	be	AUX
ajlsi-2730	44	3	identified	identify	VERB
ajlsi-2730	44	4	that	that	SCONJ
ajlsi-2730	44	5	biological	biological	ADJ
ajlsi-2730	44	6	therapy	therapy	NOUN
ajlsi-2730	44	7	has	have	AUX
ajlsi-2730	44	8	been	be	AUX
ajlsi-2730	44	9	effectively	effectively	ADV
ajlsi-2730	44	10	used	use	VERB
ajlsi-2730	44	11	to	to	PART
ajlsi-2730	44	12	treat	treat	VERB
ajlsi-2730	44	13	netherton	netherton	NOUN
ajlsi-2730	44	14	syndrome	syndrome	NOUN
ajlsi-2730	44	15	and	and	CCONJ
ajlsi-2730	44	16	autosomal	autosomal	ADJ
ajlsi-2730	44	17	recessive	recessive	ADJ
ajlsi-2730	44	18	congenital	congenital	ADJ
ajlsi-2730	44	19	ichthyosis	ichthyosis	NOUN
ajlsi-2730	44	20	(	(	PUNCT
ajlsi-2730	44	21	joosten	joosten	VERB
ajlsi-2730	44	22	et	et	PROPN
ajlsi-2730	44	23	al	al	PROPN
ajlsi-2730	44	24	.	.	PROPN
ajlsi-2730	44	25	,	,	PUNCT
ajlsi-2730	44	26	2022	2022	NUM
ajlsi-2730	44	27	)	)	PUNCT
ajlsi-2730	44	28	.	.	PUNCT
ajlsi-2730	45	1	in	in	ADP
ajlsi-2730	45	2	a	a	DET
ajlsi-2730	45	3	pediatric	pediatric	ADJ
ajlsi-2730	45	4	patient	patient	NOUN
ajlsi-2730	45	5	with	with	ADP
ajlsi-2730	45	6	severe	severe	ADJ
ajlsi-2730	45	7	erythrodermic	erythrodermic	ADJ
ajlsi-2730	45	8	autosomal	autosomal	ADJ
ajlsi-2730	45	9	recessive	recessive	ADJ
ajlsi-2730	45	10	congenital	congenital	ADJ
ajlsi-2730	45	11	ichthyosis	ichthyosis	NOUN
ajlsi-2730	45	12	(	(	PUNCT
ajlsi-2730	45	13	arci	arci	NOUN
ajlsi-2730	45	14	)	)	PUNCT
ajlsi-2730	45	15	,	,	PUNCT
ajlsi-2730	45	16	secukinumab	secukinumab	NOUN
ajlsi-2730	45	17	was	be	AUX
ajlsi-2730	45	18	found	find	VERB
ajlsi-2730	45	19	to	to	PART
ajlsi-2730	45	20	exhibit	exhibit	VERB
ajlsi-2730	45	21	clinical	clinical	ADJ
ajlsi-2730	45	22	efficacy	efficacy	NOUN
ajlsi-2730	45	23	and	and	CCONJ
ajlsi-2730	45	24	safety	safety	NOUN
ajlsi-2730	45	25	,	,	PUNCT
ajlsi-2730	45	26	resulting	result	VERB
ajlsi-2730	45	27	in	in	ADP
ajlsi-2730	45	28	a	a	DET
ajlsi-2730	45	29	48	48	NUM
ajlsi-2730	45	30	%	%	NOUN
ajlsi-2730	45	31	reduction	reduction	NOUN
ajlsi-2730	45	32	in	in	ADP
ajlsi-2730	45	33	the	the	DET
ajlsi-2730	45	34	baseline	baseline	NOUN
ajlsi-2730	45	35	score	score	NOUN
ajlsi-2730	45	36	,	,	PUNCT
ajlsi-2730	45	37	a	a	DET
ajlsi-2730	45	38	reduction	reduction	NOUN
ajlsi-2730	45	39	in	in	ADP
ajlsi-2730	45	40	proinflammatory	proinflammatory	ADJ
ajlsi-2730	45	41	cytokines	cytokine	NOUN
ajlsi-2730	45	42	,	,	PUNCT
ajlsi-2730	45	43	and	and	CCONJ
ajlsi-2730	45	44	an	an	DET
ajlsi-2730	45	45	abrogation	abrogation	NOUN
ajlsi-2730	45	46	of	of	ADP
ajlsi-2730	45	47	th17skewing	th17skewing	PROPN
ajlsi-2730	45	48	(	(	PUNCT
ajlsi-2730	45	49	yogarajah	yogarajah	PROPN
ajlsi-2730	45	50	et	et	PROPN
ajlsi-2730	45	51	al	al	PROPN
ajlsi-2730	45	52	.	.	PROPN
ajlsi-2730	45	53	,	,	PUNCT
ajlsi-2730	45	54	2021	2021	NUM
ajlsi-2730	45	55	)	)	PUNCT
ajlsi-2730	45	56	.	.	PUNCT
ajlsi-2730	46	1	there	there	PRON
ajlsi-2730	46	2	is	be	VERB
ajlsi-2730	46	3	no	no	DET
ajlsi-2730	46	4	particular	particular	ADJ
ajlsi-2730	46	5	treatment	treatment	NOUN
ajlsi-2730	46	6	for	for	ADP
ajlsi-2730	46	7	ichthyosis	ichthyosis	NOUN
ajlsi-2730	46	8	;	;	PUNCT
ajlsi-2730	46	9	it	it	PRON
ajlsi-2730	46	10	is	be	AUX
ajlsi-2730	46	11	managed	manage	VERB
ajlsi-2730	46	12	with	with	ADP
ajlsi-2730	46	13	systemic	systemic	ADJ
ajlsi-2730	46	14	therapy	therapy	NOUN
ajlsi-2730	46	15	,	,	PUNCT
ajlsi-2730	46	16	which	which	PRON
ajlsi-2730	46	17	includes	include	VERB
ajlsi-2730	46	18	uv	uv	NOUN
ajlsi-2730	46	19	radiation	radiation	NOUN
ajlsi-2730	46	20	,	,	PUNCT
ajlsi-2730	46	21	moisturizing	moisturizing	NOUN
ajlsi-2730	46	22	medicines	medicine	NOUN
ajlsi-2730	46	23	,	,	PUNCT
ajlsi-2730	46	24	keratolytics	keratolytic	NOUN
ajlsi-2730	46	25	,	,	PUNCT
ajlsi-2730	46	26	vitamin	vitamin	VERB
ajlsi-2730	46	27	a	a	DET
ajlsi-2730	46	28	derivatives	derivative	NOUN
ajlsi-2730	46	29	,	,	PUNCT
ajlsi-2730	46	30	and	and	CCONJ
ajlsi-2730	46	31	therapeutic	therapeutic	ADJ
ajlsi-2730	46	32	baths	bath	NOUN
ajlsi-2730	46	33	(	(	PUNCT
ajlsi-2730	46	34	takhtarova	takhtarova	X
ajlsi-2730	46	35	et	et	NOUN
ajlsi-2730	46	36	al	al	PROPN
ajlsi-2730	46	37	.	.	PROPN
ajlsi-2730	46	38	,	,	PUNCT
ajlsi-2730	46	39	2021	2021	NUM
ajlsi-2730	46	40	)	)	PUNCT
ajlsi-2730	46	41	.	.	PUNCT
ajlsi-2730	47	1	alpha	alpha	NOUN
ajlsi-2730	47	2	-	-	PUNCT
ajlsi-2730	47	3	hydroxy	hydroxy	PROPN
ajlsi-2730	47	4	acids	acid	NOUN
ajlsi-2730	47	5	(	(	PUNCT
ajlsi-2730	47	6	ahas	aha	NOUN
ajlsi-2730	47	7	)	)	PUNCT
ajlsi-2730	47	8	like	like	ADP
ajlsi-2730	47	9	lactic	lactic	NOUN
ajlsi-2730	47	10	,	,	PUNCT
ajlsi-2730	47	11	glycolic	glycolic	NOUN
ajlsi-2730	47	12	,	,	PUNCT
ajlsi-2730	47	13	or	or	CCONJ
ajlsi-2730	47	14	pyruvic	pyruvic	ADJ
ajlsi-2730	47	15	acids	acid	NOUN
ajlsi-2730	47	16	are	be	AUX
ajlsi-2730	47	17	used	use	VERB
ajlsi-2730	47	18	to	to	PART
ajlsi-2730	47	19	hydrate	hydrate	VERB
ajlsi-2730	47	20	skin	skin	NOUN
ajlsi-2730	47	21	in	in	ADP
ajlsi-2730	47	22	children	child	NOUN
ajlsi-2730	47	23	with	with	ADP
ajlsi-2730	47	24	ichthyosis	ichthyosis	NOUN
ajlsi-2730	47	25	by	by	ADP
ajlsi-2730	47	26	disintegrating	disintegrate	VERB
ajlsi-2730	47	27	corneocytes	corneocyte	NOUN
ajlsi-2730	47	28	in	in	ADP
ajlsi-2730	47	29	the	the	DET
ajlsi-2730	47	30	stratum	stratum	NOUN
ajlsi-2730	47	31	corneum	corneum	NOUN
ajlsi-2730	47	32	,	,	PUNCT
ajlsi-2730	47	33	improving	improve	VERB
ajlsi-2730	47	34	moisture	moisture	NOUN
ajlsi-2730	47	35	and	and	CCONJ
ajlsi-2730	47	36	decreasing	decrease	VERB
ajlsi-2730	47	37	thickness	thickness	NOUN
ajlsi-2730	47	38	.	.	PUNCT
ajlsi-2730	48	1	particularly	particularly	ADV
ajlsi-2730	48	2	,	,	PUNCT
ajlsi-2730	48	3	lactic	lactic	ADJ
ajlsi-2730	48	4	acid	acid	NOUN
ajlsi-2730	48	5	has	have	AUX
ajlsi-2730	48	6	demonstrated	demonstrate	VERB
ajlsi-2730	48	7	efficacy	efficacy	NOUN
ajlsi-2730	48	8	over	over	ADP
ajlsi-2730	48	9	petrolatum	petrolatum	NOUN
ajlsi-2730	48	10	-	-	PUNCT
ajlsi-2730	48	11	based	base	VERB
ajlsi-2730	48	12	creams	cream	NOUN
ajlsi-2730	48	13	in	in	ADP
ajlsi-2730	48	14	treating	treat	VERB
ajlsi-2730	48	15	ichthyosis	ichthyosis	NOUN
ajlsi-2730	48	16	vulgaris	vulgaris	NOUN
ajlsi-2730	48	17	.	.	PUNCT
ajlsi-2730	49	1	it	it	PRON
ajlsi-2730	49	2	can	can	AUX
ajlsi-2730	49	3	be	be	AUX
ajlsi-2730	49	4	obtained	obtain	VERB
ajlsi-2730	49	5	as	as	ADP
ajlsi-2730	49	6	a	a	DET
ajlsi-2730	49	7	12	12	NUM
ajlsi-2730	49	8	%	%	NOUN
ajlsi-2730	49	9	ammonium	ammonium	NOUN
ajlsi-2730	49	10	lactate	lactate	NOUN
ajlsi-2730	49	11	lotion	lotion	NOUN
ajlsi-2730	49	12	or	or	CCONJ
ajlsi-2730	49	13	compounded	compound	VERB
ajlsi-2730	49	14	in	in	ADP
ajlsi-2730	49	15	a	a	DET
ajlsi-2730	49	16	5–10	5–10	ADJ
ajlsi-2730	49	17	%	%	NOUN
ajlsi-2730	49	18	concentration	concentration	NOUN
ajlsi-2730	49	19	.	.	PUNCT
ajlsi-2730	50	1	ahas	ahas	PROPN
ajlsi-2730	50	2	also	also	ADV
ajlsi-2730	50	3	help	help	VERB
ajlsi-2730	50	4	to	to	PART
ajlsi-2730	50	5	improve	improve	VERB
ajlsi-2730	50	6	desquamation	desquamation	NOUN
ajlsi-2730	50	7	and	and	CCONJ
ajlsi-2730	50	8	decrease	decrease	VERB
ajlsi-2730	50	9	corneocyte	corneocyte	ADJ
ajlsi-2730	50	10	adhesion	adhesion	NOUN
ajlsi-2730	50	11	,	,	PUNCT
ajlsi-2730	50	12	which	which	PRON
ajlsi-2730	50	13	makes	make	VERB
ajlsi-2730	50	14	them	they	PRON
ajlsi-2730	50	15	useful	useful	ADJ
ajlsi-2730	50	16	for	for	ADP
ajlsi-2730	50	17	treating	treat	VERB
ajlsi-2730	50	18	children	child	NOUN
ajlsi-2730	50	19	’s	’s	PART
ajlsi-2730	50	20	ichthyosis	ichthyosis	NOUN
ajlsi-2730	50	21	symptoms	symptom	NOUN
ajlsi-2730	50	22	(	(	PUNCT
ajlsi-2730	50	23	palmer	palmer	PROPN
ajlsi-2730	50	24	&	&	CCONJ
ajlsi-2730	50	25	dunwell	dunwell	PROPN
ajlsi-2730	50	26	,	,	PUNCT
ajlsi-2730	50	27	2022	2022	NUM
ajlsi-2730	50	28	)	)	PUNCT
ajlsi-2730	50	29	.	.	PUNCT
ajlsi-2730	51	1	salicylic	salicylic	PROPN
ajlsi-2730	51	2	acid	acid	PROPN
ajlsi-2730	51	3	,	,	PUNCT
ajlsi-2730	51	4	a	a	DET
ajlsi-2730	51	5	keratolytic	keratolytic	ADJ
ajlsi-2730	51	6	agent	agent	NOUN
ajlsi-2730	51	7	,	,	PUNCT
ajlsi-2730	51	8	is	be	AUX
ajlsi-2730	51	9	frequently	frequently	ADV
ajlsi-2730	51	10	used	use	VERB
ajlsi-2730	51	11	to	to	PART
ajlsi-2730	51	12	treat	treat	VERB
ajlsi-2730	51	13	ichthyosis	ichthyosis	NOUN
ajlsi-2730	51	14	because	because	SCONJ
ajlsi-2730	51	15	it	it	PRON
ajlsi-2730	51	16	softens	soften	VERB
ajlsi-2730	51	17	keratin	keratin	NOUN
ajlsi-2730	51	18	,	,	PUNCT
ajlsi-2730	51	19	loosens	loosen	VERB
ajlsi-2730	51	20	scaly	scaly	NOUN
ajlsi-2730	51	21	,	,	PUNCT
ajlsi-2730	51	22	dry	dry	ADJ
ajlsi-2730	51	23	skin	skin	NOUN
ajlsi-2730	51	24	,	,	PUNCT
ajlsi-2730	51	25	and	and	CCONJ
ajlsi-2730	51	26	facilitates	facilitate	VERB
ajlsi-2730	51	27	removal	removal	NOUN
ajlsi-2730	51	28	.	.	PUNCT
ajlsi-2730	52	1	although	although	SCONJ
ajlsi-2730	52	2	it	it	PRON
ajlsi-2730	52	3	is	be	AUX
ajlsi-2730	52	4	usually	usually	ADV
ajlsi-2730	52	5	well	well	ADV
ajlsi-2730	52	6	tolerated	tolerate	VERB
ajlsi-2730	52	7	,	,	PUNCT
ajlsi-2730	52	8	it	it	PRON
ajlsi-2730	52	9	may	may	AUX
ajlsi-2730	52	10	result	result	VERB
ajlsi-2730	52	11	in	in	ADP
ajlsi-2730	52	12	mild	mild	ADJ
ajlsi-2730	52	13	hives	hive	NOUN
ajlsi-2730	52	14	,	,	PUNCT
ajlsi-2730	52	15	irritation	irritation	NOUN
ajlsi-2730	52	16	,	,	PUNCT
ajlsi-2730	52	17	rash	rash	ADJ
ajlsi-2730	52	18	,	,	PUNCT
ajlsi-2730	52	19	dryness	dryness	NOUN
ajlsi-2730	52	20	,	,	PUNCT
ajlsi-2730	52	21	peeling	peeling	NOUN
ajlsi-2730	52	22	,	,	PUNCT
ajlsi-2730	52	23	itching	itching	NOUN
ajlsi-2730	52	24	,	,	PUNCT
ajlsi-2730	52	25	redness	redness	NOUN
ajlsi-2730	52	26	,	,	PUNCT
ajlsi-2730	52	27	and	and	CCONJ
ajlsi-2730	52	28	skin	skin	NOUN
ajlsi-2730	52	29	swelling	swelling	NOUN
ajlsi-2730	52	30	.	.	PUNCT
ajlsi-2730	53	1	adverse	adverse	ADJ
ajlsi-2730	53	2	effects	effect	NOUN
ajlsi-2730	53	3	might	might	AUX
ajlsi-2730	53	4	be	be	AUX
ajlsi-2730	53	5	quite	quite	ADV
ajlsi-2730	53	6	serious	serious	ADJ
ajlsi-2730	53	7	in	in	ADP
ajlsi-2730	53	8	certain	certain	ADJ
ajlsi-2730	53	9	instances	instance	NOUN
ajlsi-2730	53	10	.	.	PUNCT
ajlsi-2730	54	1	preparations	preparation	NOUN
ajlsi-2730	54	2	of	of	ADP
ajlsi-2730	54	3	salicylic	salicylic	ADJ
ajlsi-2730	54	4	acid	acid	NOUN
ajlsi-2730	54	5	with	with	ADP
ajlsi-2730	54	6	concentrations	concentration	NOUN
ajlsi-2730	54	7	ranging	range	VERB
ajlsi-2730	54	8	from	from	ADP
ajlsi-2730	54	9	0.5	0.5	NUM
ajlsi-2730	54	10	%	%	NOUN
ajlsi-2730	54	11	to	to	PART
ajlsi-2730	54	12	30	30	NUM
ajlsi-2730	54	13	%	%	NOUN
ajlsi-2730	54	14	and	and	CCONJ
ajlsi-2730	54	15	6	6	NUM
ajlsi-2730	54	16	%	%	NOUN
ajlsi-2730	54	17	,	,	PUNCT
ajlsi-2730	54	18	particularly	particularly	ADV
ajlsi-2730	54	19	in	in	ADP
ajlsi-2730	54	20	pediatrics	pediatric	NOUN
ajlsi-2730	54	21	,	,	PUNCT
ajlsi-2730	54	22	are	be	AUX
ajlsi-2730	54	23	used	use	VERB
ajlsi-2730	54	24	to	to	PART
ajlsi-2730	54	25	treat	treat	VERB
ajlsi-2730	54	26	particular	particular	ADJ
ajlsi-2730	54	27	ailments	ailment	NOUN
ajlsi-2730	54	28	of	of	ADP
ajlsi-2730	54	29	ichthyosis	ichthyosis	NOUN
ajlsi-2730	54	30	in	in	ADP
ajlsi-2730	54	31	children	child	NOUN
ajlsi-2730	54	32	(	(	PUNCT
ajlsi-2730	54	33	cortés	cortés	VERB
ajlsi-2730	54	34	et	et	PROPN
ajlsi-2730	54	35	al	al	PROPN
ajlsi-2730	54	36	.	.	PROPN
ajlsi-2730	54	37	,	,	PUNCT
ajlsi-2730	54	38	2020	2020	NUM
ajlsi-2730	54	39	)	)	PUNCT
ajlsi-2730	54	40	.	.	PUNCT
ajlsi-2730	55	1	vitamin	vitamin	NOUN
ajlsi-2730	55	2	b5	b5	PROPN
ajlsi-2730	55	3	in	in	ADP
ajlsi-2730	55	4	dexpanthenol	dexpanthenol	NOUN
ajlsi-2730	55	5	is	be	AUX
ajlsi-2730	55	6	a	a	DET
ajlsi-2730	55	7	helpful	helpful	ADJ
ajlsi-2730	55	8	treatment	treatment	NOUN
ajlsi-2730	55	9	for	for	ADP
ajlsi-2730	55	10	children	child	NOUN
ajlsi-2730	55	11	with	with	ADP
ajlsi-2730	55	12	ichthyosis	ichthyosis	NOUN
ajlsi-2730	55	13	vulgaris	vulgaris	NOUN
ajlsi-2730	55	14	.	.	PUNCT
ajlsi-2730	56	1	it	it	PRON
ajlsi-2730	56	2	is	be	AUX
ajlsi-2730	56	3	a	a	DET
ajlsi-2730	56	4	good	good	ADJ
ajlsi-2730	56	5	alternative	alternative	NOUN
ajlsi-2730	56	6	to	to	PART
ajlsi-2730	56	7	use	use	VERB
ajlsi-2730	56	8	as	as	ADP
ajlsi-2730	56	9	a	a	DET
ajlsi-2730	56	10	first	first	ADJ
ajlsi-2730	56	11	-	-	PUNCT
ajlsi-2730	56	12	line	line	NOUN
ajlsi-2730	56	13	therapy	therapy	NOUN
ajlsi-2730	56	14	to	to	PART
ajlsi-2730	56	15	enhance	enhance	VERB
ajlsi-2730	56	16	skin	skin	NOUN
ajlsi-2730	56	17	moisture	moisture	NOUN
ajlsi-2730	56	18	and	and	CCONJ
ajlsi-2730	56	19	lessen	lessen	VERB
ajlsi-2730	56	20	dryness	dryness	NOUN
ajlsi-2730	56	21	and	and	CCONJ
ajlsi-2730	56	22	scaling	scaling	NOUN
ajlsi-2730	56	23	(	(	PUNCT
ajlsi-2730	56	24	cortés	cortés	NOUN
ajlsi-2730	56	25	et	et	PROPN
ajlsi-2730	56	26	al	al	PROPN
ajlsi-2730	56	27	.	.	PROPN
ajlsi-2730	56	28	,	,	PUNCT
ajlsi-2730	56	29	2020	2020	NUM
ajlsi-2730	56	30	)	)	PUNCT
ajlsi-2730	56	31	.	.	PUNCT
ajlsi-2730	57	1	children	child	NOUN
ajlsi-2730	57	2	with	with	ADP
ajlsi-2730	57	3	ichthyosis	ichthyosis	NOUN
ajlsi-2730	57	4	are	be	AUX
ajlsi-2730	57	5	treated	treat	VERB
ajlsi-2730	57	6	with	with	ADP
ajlsi-2730	57	7	emollient	emollient	NOUN
ajlsi-2730	57	8	lotions	lotion	NOUN
ajlsi-2730	57	9	such	such	ADJ
ajlsi-2730	57	10	as	as	ADP
ajlsi-2730	57	11	dexeryl	dexeryl	NOUN
ajlsi-2730	57	12	,	,	PUNCT
ajlsi-2730	57	13	which	which	PRON
ajlsi-2730	57	14	contains	contain	VERB
ajlsi-2730	57	15	glycerol	glycerol	NOUN
ajlsi-2730	57	16	.	.	PUNCT
ajlsi-2730	58	1	based	base	VERB
ajlsi-2730	58	2	on	on	ADP
ajlsi-2730	58	3	studies	study	NOUN
ajlsi-2730	58	4	,	,	PUNCT
ajlsi-2730	58	5	dexeryl	dexeryl	PROPN
ajlsi-2730	58	6	improves	improve	VERB
ajlsi-2730	58	7	skin	skin	NOUN
ajlsi-2730	58	8	condition	condition	NOUN
ajlsi-2730	58	9	by	by	ADP
ajlsi-2730	58	10	lessening	lessen	VERB
ajlsi-2730	58	11	the	the	DET
ajlsi-2730	58	12	severity	severity	NOUN
ajlsi-2730	58	13	of	of	ADP
ajlsi-2730	58	14	xerosis	xerosis	NOUN
ajlsi-2730	58	15	and	and	CCONJ
ajlsi-2730	58	16	its	its	PRON
ajlsi-2730	58	17	associated	associated	ADJ
ajlsi-2730	58	18	symptoms	symptom	NOUN
ajlsi-2730	58	19	.	.	PUNCT
ajlsi-2730	59	1	in	in	ADP
ajlsi-2730	59	2	80	80	NUM
ajlsi-2730	59	3	%	%	NOUN
ajlsi-2730	59	4	of	of	ADP
ajlsi-2730	59	5	treated	treat	VERB
ajlsi-2730	59	6	youngsters	youngster	NOUN
ajlsi-2730	59	7	,	,	PUNCT
ajlsi-2730	59	8	it	it	PRON
ajlsi-2730	59	9	is	be	AUX
ajlsi-2730	59	10	both	both	CCONJ
ajlsi-2730	59	11	effective	effective	ADJ
ajlsi-2730	59	12	and	and	CCONJ
ajlsi-2730	59	13	welltolerated	welltolerate	VERB
ajlsi-2730	59	14	.	.	PUNCT
ajlsi-2730	60	1	thick	thick	ADJ
ajlsi-2730	60	2	,	,	PUNCT
ajlsi-2730	60	3	scaly	scaly	NOUN
ajlsi-2730	60	4	,	,	PUNCT
ajlsi-2730	60	5	dry	dry	ADJ
ajlsi-2730	60	6	,	,	PUNCT
ajlsi-2730	60	7	and	and	CCONJ
ajlsi-2730	60	8	cracked	crack	VERB
ajlsi-2730	60	9	skin	skin	NOUN
ajlsi-2730	60	10	are	be	AUX
ajlsi-2730	60	11	the	the	DET
ajlsi-2730	60	12	signs	sign	NOUN
ajlsi-2730	60	13	this	this	DET
ajlsi-2730	60	14	treatment	treatment	NOUN
ajlsi-2730	60	15	targets	target	NOUN
ajlsi-2730	60	16	(	(	PUNCT
ajlsi-2730	60	17	blanchet‐bardon	blanchet‐bardon	PROPN
ajlsi-2730	60	18	et	et	PROPN
ajlsi-2730	60	19	al	al	PROPN
ajlsi-2730	60	20	.	.	PROPN
ajlsi-2730	60	21	,	,	PUNCT
ajlsi-2730	60	22	2012	2012	NUM
ajlsi-2730	60	23	)	)	PUNCT
ajlsi-2730	60	24	.	.	PUNCT
ajlsi-2730	61	1	propylene	propylene	NOUN
ajlsi-2730	61	2	glycol	glycol	NOUN
ajlsi-2730	61	3	is	be	AUX
ajlsi-2730	61	4	a	a	DET
ajlsi-2730	61	5	useful	useful	ADJ
ajlsi-2730	61	6	treatment	treatment	NOUN
ajlsi-2730	61	7	for	for	ADP
ajlsi-2730	61	8	several	several	ADJ
ajlsi-2730	61	9	conditions	condition	NOUN
ajlsi-2730	61	10	that	that	PRON
ajlsi-2730	61	11	cause	cause	VERB
ajlsi-2730	61	12	the	the	DET
ajlsi-2730	61	13	skin	skin	NOUN
ajlsi-2730	61	14	to	to	PART
ajlsi-2730	61	15	become	become	AUX
ajlsi-2730	61	16	scaled	scale	VERB
ajlsi-2730	61	17	.	.	PUNCT
ajlsi-2730	62	1	because	because	SCONJ
ajlsi-2730	62	2	it	it	PRON
ajlsi-2730	62	3	keeps	keep	VERB
ajlsi-2730	62	4	the	the	DET
ajlsi-2730	62	5	skin	skin	NOUN
ajlsi-2730	62	6	free	free	ADJ
ajlsi-2730	62	7	of	of	ADP
ajlsi-2730	62	8	scales	scale	NOUN
ajlsi-2730	62	9	and	and	CCONJ
ajlsi-2730	62	10	removes	remove	VERB
ajlsi-2730	62	11	them	they	PRON
ajlsi-2730	62	12	from	from	ADP
ajlsi-2730	62	13	the	the	DET
ajlsi-2730	62	14	skin	skin	NOUN
ajlsi-2730	62	15	,	,	PUNCT
ajlsi-2730	62	16	it	it	PRON
ajlsi-2730	62	17	is	be	AUX
ajlsi-2730	62	18	very	very	ADV
ajlsi-2730	62	19	effective	effective	ADJ
ajlsi-2730	62	20	in	in	ADP
ajlsi-2730	62	21	treating	treat	VERB
ajlsi-2730	62	22	ichthyosis	ichthyosis	NOUN
ajlsi-2730	62	23	(	(	PUNCT
ajlsi-2730	62	24	hernándezmartin	hernándezmartin	VERB
ajlsi-2730	62	25	et	et	PROPN
ajlsi-2730	62	26	al	al	PROPN
ajlsi-2730	62	27	.	.	PROPN
ajlsi-2730	62	28	,	,	PUNCT
ajlsi-2730	62	29	2013	2013	NUM
ajlsi-2730	62	30	)	)	PUNCT
ajlsi-2730	62	31	.	.	PUNCT
ajlsi-2730	63	1	congenital	congenital	ADJ
ajlsi-2730	63	2	ichthyosis	ichthyosis	NOUN
ajlsi-2730	63	3	patients	patient	NOUN
ajlsi-2730	63	4	may	may	AUX
ajlsi-2730	63	5	benefit	benefit	VERB
ajlsi-2730	63	6	greatly	greatly	ADV
ajlsi-2730	63	7	from	from	ADP
ajlsi-2730	63	8	vitamin	vitamin	NOUN
ajlsi-2730	63	9	d	d	NOUN
ajlsi-2730	63	10	treatment	treatment	NOUN
ajlsi-2730	63	11	,	,	PUNCT
ajlsi-2730	63	12	as	as	SCONJ
ajlsi-2730	63	13	it	it	PRON
ajlsi-2730	63	14	has	have	AUX
ajlsi-2730	63	15	demonstrated	demonstrate	VERB
ajlsi-2730	63	16	a	a	DET
ajlsi-2730	63	17	strong	strong	ADJ
ajlsi-2730	63	18	ability	ability	NOUN
ajlsi-2730	63	19	to	to	PART
ajlsi-2730	63	20	ameliorate	ameliorate	VERB
ajlsi-2730	63	21	the	the	DET
ajlsi-2730	63	22	skin	skin	NOUN
ajlsi-2730	63	23	condition	condition	NOUN
ajlsi-2730	63	24	of	of	ADP
ajlsi-2730	63	25	those	those	PRON
ajlsi-2730	63	26	afflicted	afflict	VERB
ajlsi-2730	63	27	.	.	PUNCT
ajlsi-2730	64	1	studies	study	NOUN
ajlsi-2730	64	2	have	have	AUX
ajlsi-2730	64	3	demonstrated	demonstrate	VERB
ajlsi-2730	64	4	the	the	DET
ajlsi-2730	64	5	high	high	ADJ
ajlsi-2730	64	6	incidence	incidence	NOUN
ajlsi-2730	64	7	of	of	ADP
ajlsi-2730	64	8	rickets	ricket	NOUN
ajlsi-2730	64	9	and	and	CCONJ
ajlsi-2730	64	10	severe	severe	ADJ
ajlsi-2730	64	11	vitamin	vitamin	NOUN
ajlsi-2730	64	12	d	d	NOUN
ajlsi-2730	64	13	insufficiency	insufficiency	NOUN
ajlsi-2730	64	14	in	in	ADP
ajlsi-2730	64	15	children	child	NOUN
ajlsi-2730	64	16	with	with	ADP
ajlsi-2730	64	17	congenital	congenital	ADJ
ajlsi-2730	64	18	ichthyosis	ichthyosis	NOUN
ajlsi-2730	64	19	.	.	PUNCT
ajlsi-2730	65	1	short	short	ADJ
ajlsi-2730	65	2	-	-	PUNCT
ajlsi-2730	65	3	term	term	NOUN
ajlsi-2730	65	4	high	high	ADJ
ajlsi-2730	65	5	-	-	PUNCT
ajlsi-2730	65	6	dose	dose	NOUN
ajlsi-2730	65	7	vitamin	vitamin	NOUN
ajlsi-2730	65	8	d	d	NOUN
ajlsi-2730	65	9	treatment	treatment	NOUN
ajlsi-2730	65	10	provided	provide	VERB
ajlsi-2730	65	11	a	a	DET
ajlsi-2730	65	12	notable	notable	ADJ
ajlsi-2730	65	13	clinical	clinical	ADJ
ajlsi-2730	65	14	response	response	NOUN
ajlsi-2730	65	15	in	in	ADP
ajlsi-2730	65	16	children	child	NOUN
ajlsi-2730	65	17	with	with	ADP
ajlsi-2730	65	18	congenital	congenital	ADJ
ajlsi-2730	65	19	ichthyosis	ichthyosis	NOUN
ajlsi-2730	65	20	.	.	PUNCT
ajlsi-2730	66	1	during	during	ADP
ajlsi-2730	66	2	the	the	DET
ajlsi-2730	66	3	treatment	treatment	NOUN
ajlsi-2730	66	4	,	,	PUNCT
ajlsi-2730	66	5	400	400	NUM
ajlsi-2730	66	6	–	–	PUNCT
ajlsi-2730	66	7	600	600	NUM
ajlsi-2730	66	8	iu	iu	NOUN
ajlsi-2730	66	9	of	of	ADP
ajlsi-2730	66	10	cholecalciferol	cholecalciferol	NOUN
ajlsi-2730	66	11	a	a	DET
ajlsi-2730	66	12	day	day	NOUN
ajlsi-2730	66	13	was	be	AUX
ajlsi-2730	66	14	advised	advise	VERB
ajlsi-2730	66	15	after	after	SCONJ
ajlsi-2730	66	16	60,000	60,000	NUM
ajlsi-2730	66	17	iu	iu	ADP
ajlsi-2730	66	18	of	of	ADP
ajlsi-2730	66	19	oral	oral	ADJ
ajlsi-2730	66	20	cholecalciferol	cholecalciferol	NOUN
ajlsi-2730	66	21	was	be	AUX
ajlsi-2730	66	22	given	give	VERB
ajlsi-2730	66	23	daily	daily	ADV
ajlsi-2730	66	24	for	for	ADP
ajlsi-2730	66	25	10	10	NUM
ajlsi-2730	66	26	days	day	NOUN
ajlsi-2730	66	27	.	.	PUNCT
ajlsi-2730	67	1	the	the	DET
ajlsi-2730	67	2	results	result	NOUN
ajlsi-2730	67	3	showed	show	VERB
ajlsi-2730	67	4	that	that	SCONJ
ajlsi-2730	67	5	vitamin	vitamin	NOUN
ajlsi-2730	67	6	d	d	NOUN
ajlsi-2730	67	7	treatment	treatment	NOUN
ajlsi-2730	67	8	had	have	VERB
ajlsi-2730	67	9	a	a	DET
ajlsi-2730	67	10	beneficial	beneficial	ADJ
ajlsi-2730	67	11	effect	effect	NOUN
ajlsi-2730	67	12	on	on	ADP
ajlsi-2730	67	13	the	the	DET
ajlsi-2730	67	14	symptoms	symptom	NOUN
ajlsi-2730	67	15	of	of	ADP
ajlsi-2730	67	16	congenital	congenital	ADJ
ajlsi-2730	67	17	ichthyosis	ichthyosis	NOUN
ajlsi-2730	67	18	,	,	PUNCT
ajlsi-2730	67	19	as	as	SCONJ
ajlsi-2730	67	20	evidenced	evidence	VERB
ajlsi-2730	67	21	by	by	ADP
ajlsi-2730	67	22	the	the	DET
ajlsi-2730	67	23	decrease	decrease	NOUN
ajlsi-2730	67	24	in	in	ADP
ajlsi-2730	67	25	skin	skin	NOUN
ajlsi-2730	67	26	scaling	scaling	NOUN
ajlsi-2730	67	27	and	and	CCONJ
ajlsi-2730	67	28	stiffness	stiffness	NOUN
ajlsi-2730	67	29	of	of	ADP
ajlsi-2730	67	30	the	the	DET
ajlsi-2730	67	31	extremities	extremity	NOUN
ajlsi-2730	67	32	(	(	PUNCT
ajlsi-2730	67	33	sethuraman	sethuraman	NOUN
ajlsi-2730	67	34	et	et	PROPN
ajlsi-2730	67	35	al	al	PROPN
ajlsi-2730	67	36	.	.	PROPN
ajlsi-2730	67	37	,	,	PUNCT
ajlsi-2730	67	38	2016	2016	NUM
ajlsi-2730	67	39	)	)	PUNCT
ajlsi-2730	67	40	.	.	PUNCT
ajlsi-2730	68	1	research	research	NOUN
ajlsi-2730	68	2	revealed	reveal	VERB
ajlsi-2730	68	3	that	that	SCONJ
ajlsi-2730	68	4	congenital	congenital	ADJ
ajlsi-2730	68	5	ichthyosis	ichthyosis	NOUN
ajlsi-2730	68	6	could	could	AUX
ajlsi-2730	68	7	be	be	AUX
ajlsi-2730	68	8	successfully	successfully	ADV
ajlsi-2730	68	9	treated	treat	VERB
ajlsi-2730	68	10	when	when	SCONJ
ajlsi-2730	68	11	acitretin	acitretin	NOUN
ajlsi-2730	68	12	therapy	therapy	NOUN
ajlsi-2730	68	13	was	be	AUX
ajlsi-2730	68	14	used	use	VERB
ajlsi-2730	68	15	to	to	PART
ajlsi-2730	68	16	treat	treat	VERB
ajlsi-2730	68	17	a	a	DET
ajlsi-2730	68	18	newborn	newborn	ADJ
ajlsi-2730	68	19	baby	baby	NOUN
ajlsi-2730	68	20	’s	’s	PART
ajlsi-2730	68	21	skin	skin	NOUN
ajlsi-2730	68	22	condition	condition	NOUN
ajlsi-2730	68	23	,	,	PUNCT
ajlsi-2730	68	24	even	even	ADV
ajlsi-2730	68	25	though	though	SCONJ
ajlsi-2730	68	26	pa	pa	PROPN
ajlsi-2730	68	27	ge	ge	PROPN
ajlsi-2730	68	28	71	71	NUM
ajlsi-2730	68	29	https://journals.e-palli.com/home/index.php/ajlsi	https://journals.e-palli.com/home/index.php/ajlsi	PROPN
ajlsi-2730	68	30	am	am	NOUN
ajlsi-2730	68	31	.	.	PUNCT
ajlsi-2730	69	1	j.	j.	PROPN
ajlsi-2730	69	2	life	life	PROPN
ajlsi-2730	69	3	sci	sci	PROPN
ajlsi-2730	69	4	.	.	PUNCT
ajlsi-2730	69	5	innov	innov	PROPN
ajlsi-2730	69	6	.	.	PUNCT
ajlsi-2730	70	1	3(1	3(1	NUM
ajlsi-2730	70	2	)	)	PUNCT
ajlsi-2730	71	1	69	69	NUM
ajlsi-2730	71	2	-	-	SYM
ajlsi-2730	71	3	74	74	NUM
ajlsi-2730	71	4	,	,	PUNCT
ajlsi-2730	71	5	2024	2024	NUM
ajlsi-2730	71	6	the	the	DET
ajlsi-2730	71	7	baby	baby	NOUN
ajlsi-2730	71	8	’s	’s	PART
ajlsi-2730	71	9	skin	skin	NOUN
ajlsi-2730	71	10	condition	condition	NOUN
ajlsi-2730	71	11	had	have	AUX
ajlsi-2730	71	12	not	not	PART
ajlsi-2730	71	13	improved	improve	VERB
ajlsi-2730	71	14	with	with	ADP
ajlsi-2730	71	15	liquid	liquid	ADJ
ajlsi-2730	71	16	vaseline	vaseline	NOUN
ajlsi-2730	71	17	treatment	treatment	NOUN
ajlsi-2730	71	18	(	(	PUNCT
ajlsi-2730	71	19	gulasi	gulasi	NOUN
ajlsi-2730	71	20	,	,	PUNCT
ajlsi-2730	71	21	2016	2016	NUM
ajlsi-2730	71	22	)	)	PUNCT
ajlsi-2730	71	23	.	.	PUNCT
ajlsi-2730	72	1	if	if	SCONJ
ajlsi-2730	72	2	congenital	congenital	ADJ
ajlsi-2730	72	3	ichthyosis	ichthyosis	NOUN
ajlsi-2730	72	4	is	be	AUX
ajlsi-2730	72	5	treated	treat	VERB
ajlsi-2730	72	6	,	,	PUNCT
ajlsi-2730	72	7	acitretin	acitretin	VERB
ajlsi-2730	72	8	0.5	0.5	NUM
ajlsi-2730	72	9	mg	mg	PROPN
ajlsi-2730	72	10	/	/	SYM
ajlsi-2730	72	11	kg/	kg/	NOUN
ajlsi-2730	72	12	day	day	NOUN
ajlsi-2730	72	13	should	should	AUX
ajlsi-2730	72	14	be	be	AUX
ajlsi-2730	72	15	administered	administer	VERB
ajlsi-2730	72	16	initially	initially	ADV
ajlsi-2730	72	17	and	and	CCONJ
ajlsi-2730	72	18	1	1	NUM
ajlsi-2730	72	19	mg	mg	PROPN
ajlsi-2730	72	20	/	/	SYM
ajlsi-2730	72	21	kg	kg	NOUN
ajlsi-2730	72	22	/	/	SYM
ajlsi-2730	72	23	day	day	NOUN
ajlsi-2730	72	24	after	after	ADP
ajlsi-2730	72	25	two	two	NUM
ajlsi-2730	72	26	months	month	NOUN
ajlsi-2730	72	27	.	.	PUNCT
ajlsi-2730	73	1	as	as	SCONJ
ajlsi-2730	73	2	the	the	DET
ajlsi-2730	73	3	highest	high	ADJ
ajlsi-2730	73	4	doses	dose	NOUN
ajlsi-2730	73	5	do	do	AUX
ajlsi-2730	73	6	not	not	PART
ajlsi-2730	73	7	exceed	exceed	VERB
ajlsi-2730	73	8	1	1	NUM
ajlsi-2730	73	9	mg	mg	NUM
ajlsi-2730	73	10	/	/	SYM
ajlsi-2730	73	11	kg	kg	PROPN
ajlsi-2730	73	12	/	/	SYM
ajlsi-2730	73	13	day	day	NOUN
ajlsi-2730	73	14	,	,	PUNCT
ajlsi-2730	73	15	its	its	PRON
ajlsi-2730	73	16	short	short	ADJ
ajlsi-2730	73	17	plasma	plasma	NOUN
ajlsi-2730	73	18	half	half	ADJ
ajlsi-2730	73	19	-	-	PUNCT
ajlsi-2730	73	20	life	life	NOUN
ajlsi-2730	73	21	minimizes	minimize	VERB
ajlsi-2730	73	22	negative	negative	ADJ
ajlsi-2730	73	23	effects	effect	NOUN
ajlsi-2730	73	24	(	(	PUNCT
ajlsi-2730	73	25	zaenglein	zaenglein	NOUN
ajlsi-2730	73	26	et	et	PROPN
ajlsi-2730	73	27	al	al	PROPN
ajlsi-2730	73	28	.	.	PROPN
ajlsi-2730	73	29	,	,	PUNCT
ajlsi-2730	73	30	2021	2021	NUM
ajlsi-2730	73	31	)	)	PUNCT
ajlsi-2730	73	32	.	.	PUNCT
ajlsi-2730	74	1	immune	immune	ADJ
ajlsi-2730	74	2	system	system	NOUN
ajlsi-2730	74	3	inhibitors	inhibitor	NOUN
ajlsi-2730	74	4	such	such	ADJ
ajlsi-2730	74	5	as	as	ADP
ajlsi-2730	74	6	etanercept	etanercept	NOUN
ajlsi-2730	74	7	(	(	PUNCT
ajlsi-2730	74	8	tnfalpha	tnfalpha	ADJ
ajlsi-2730	74	9	inhibitors	inhibitor	NOUN
ajlsi-2730	74	10	)	)	PUNCT
ajlsi-2730	74	11	have	have	VERB
ajlsi-2730	74	12	no	no	DET
ajlsi-2730	74	13	adverse	adverse	ADJ
ajlsi-2730	74	14	effects	effect	NOUN
ajlsi-2730	74	15	when	when	SCONJ
ajlsi-2730	74	16	used	use	VERB
ajlsi-2730	74	17	to	to	PART
ajlsi-2730	74	18	treat	treat	VERB
ajlsi-2730	74	19	juvenile	juvenile	ADJ
ajlsi-2730	74	20	idiopathic	idiopathic	ADJ
ajlsi-2730	74	21	arthritis	arthritis	NOUN
ajlsi-2730	74	22	and	and	CCONJ
ajlsi-2730	74	23	harlequin	harlequin	NOUN
ajlsi-2730	74	24	ichthyosis	ichthyosis	NOUN
ajlsi-2730	74	25	in	in	ADP
ajlsi-2730	74	26	children	child	NOUN
ajlsi-2730	74	27	(	(	PUNCT
ajlsi-2730	74	28	baldo	baldo	PROPN
ajlsi-2730	74	29	et	et	PROPN
ajlsi-2730	74	30	al	al	PROPN
ajlsi-2730	74	31	.	.	PROPN
ajlsi-2730	74	32	,	,	PUNCT
ajlsi-2730	74	33	2021	2021	NUM
ajlsi-2730	74	34	)	)	PUNCT
ajlsi-2730	74	35	.	.	PUNCT
ajlsi-2730	75	1	on	on	ADP
ajlsi-2730	75	2	the	the	DET
ajlsi-2730	75	3	other	other	ADJ
ajlsi-2730	75	4	hand	hand	NOUN
ajlsi-2730	75	5	,	,	PUNCT
ajlsi-2730	75	6	studies	study	NOUN
ajlsi-2730	75	7	indicated	indicate	VERB
ajlsi-2730	75	8	that	that	SCONJ
ajlsi-2730	75	9	adalimumab	adalimumab	NOUN
ajlsi-2730	75	10	is	be	AUX
ajlsi-2730	75	11	also	also	ADV
ajlsi-2730	75	12	used	use	VERB
ajlsi-2730	75	13	to	to	PART
ajlsi-2730	75	14	treat	treat	VERB
ajlsi-2730	75	15	ichthyosis	ichthyosis	NOUN
ajlsi-2730	75	16	in	in	ADP
ajlsi-2730	75	17	children	child	NOUN
ajlsi-2730	75	18	;	;	PUNCT
ajlsi-2730	75	19	it	it	PRON
ajlsi-2730	75	20	targets	target	VERB
ajlsi-2730	75	21	the	the	DET
ajlsi-2730	75	22	cytokine	cytokine	NOUN
ajlsi-2730	75	23	tnf	tnf	PROPN
ajlsi-2730	75	24	-	-	PUNCT
ajlsi-2730	75	25	alpha	alpha	NOUN
ajlsi-2730	75	26	,	,	PUNCT
ajlsi-2730	75	27	which	which	PRON
ajlsi-2730	75	28	is	be	AUX
ajlsi-2730	75	29	linked	link	VERB
ajlsi-2730	75	30	to	to	ADP
ajlsi-2730	75	31	inflammation	inflammation	NOUN
ajlsi-2730	75	32	.	.	PUNCT
ajlsi-2730	76	1	it	it	PRON
ajlsi-2730	76	2	helps	help	VERB
ajlsi-2730	76	3	to	to	PART
ajlsi-2730	76	4	improve	improve	VERB
ajlsi-2730	76	5	skin	skin	NOUN
ajlsi-2730	76	6	conditions	condition	NOUN
ajlsi-2730	76	7	and	and	CCONJ
ajlsi-2730	76	8	manage	manage	VERB
ajlsi-2730	76	9	symptoms	symptom	NOUN
ajlsi-2730	76	10	(	(	PUNCT
ajlsi-2730	76	11	sticherling	sticherling	NOUN
ajlsi-2730	76	12	,	,	PUNCT
ajlsi-2730	76	13	2020	2020	NUM
ajlsi-2730	76	14	)	)	PUNCT
ajlsi-2730	76	15	.	.	PUNCT
ajlsi-2730	77	1	it	it	PRON
ajlsi-2730	77	2	has	have	AUX
ajlsi-2730	77	3	been	be	AUX
ajlsi-2730	77	4	demonstrated	demonstrate	VERB
ajlsi-2730	77	5	that	that	SCONJ
ajlsi-2730	77	6	infliximab	infliximab	NOUN
ajlsi-2730	77	7	treatment	treatment	NOUN
ajlsi-2730	77	8	is	be	AUX
ajlsi-2730	77	9	beneficial	beneficial	ADJ
ajlsi-2730	77	10	in	in	ADP
ajlsi-2730	77	11	lowering	lower	VERB
ajlsi-2730	77	12	skin	skin	NOUN
ajlsi-2730	77	13	inflammation	inflammation	NOUN
ajlsi-2730	77	14	in	in	ADP
ajlsi-2730	77	15	children	child	NOUN
ajlsi-2730	77	16	with	with	ADP
ajlsi-2730	77	17	ichthyosis	ichthyosis	NOUN
ajlsi-2730	77	18	,	,	PUNCT
ajlsi-2730	77	19	including	include	VERB
ajlsi-2730	77	20	netherton	netherton	NOUN
ajlsi-2730	77	21	syndrome	syndrome	NOUN
ajlsi-2730	77	22	.	.	PUNCT
ajlsi-2730	78	1	studies	study	NOUN
ajlsi-2730	78	2	have	have	AUX
ajlsi-2730	78	3	demonstrated	demonstrate	VERB
ajlsi-2730	78	4	that	that	SCONJ
ajlsi-2730	78	5	infliximab	infliximab	NOUN
ajlsi-2730	78	6	can	can	AUX
ajlsi-2730	78	7	improve	improve	VERB
ajlsi-2730	78	8	skin	skin	NOUN
ajlsi-2730	78	9	lesions	lesion	NOUN
ajlsi-2730	78	10	by	by	ADP
ajlsi-2730	78	11	reducing	reduce	VERB
ajlsi-2730	78	12	the	the	DET
ajlsi-2730	78	13	expression	expression	NOUN
ajlsi-2730	78	14	of	of	ADP
ajlsi-2730	78	15	several	several	ADJ
ajlsi-2730	78	16	inflammatory	inflammatory	ADJ
ajlsi-2730	78	17	markers	marker	NOUN
ajlsi-2730	78	18	,	,	PUNCT
ajlsi-2730	78	19	such	such	ADJ
ajlsi-2730	78	20	as	as	ADP
ajlsi-2730	78	21	tslp	tslp	ADJ
ajlsi-2730	78	22	,	,	PUNCT
ajlsi-2730	78	23	il-6	il-6	NOUN
ajlsi-2730	78	24	,	,	PUNCT
ajlsi-2730	78	25	and	and	CCONJ
ajlsi-2730	78	26	il-8	il-8	NOUN
ajlsi-2730	78	27	.	.	PUNCT
ajlsi-2730	79	1	clinical	clinical	ADJ
ajlsi-2730	79	2	investigations	investigation	NOUN
ajlsi-2730	79	3	have	have	AUX
ajlsi-2730	79	4	shown	show	VERB
ajlsi-2730	79	5	that	that	SCONJ
ajlsi-2730	79	6	infliximab	infliximab	NOUN
ajlsi-2730	79	7	treatment	treatment	NOUN
ajlsi-2730	79	8	significantly	significantly	ADV
ajlsi-2730	79	9	improves	improve	VERB
ajlsi-2730	79	10	the	the	DET
ajlsi-2730	79	11	skin	skin	NOUN
ajlsi-2730	79	12	signs	sign	NOUN
ajlsi-2730	79	13	of	of	ADP
ajlsi-2730	79	14	netherton	netherton	NOUN
ajlsi-2730	79	15	syndrome	syndrome	NOUN
ajlsi-2730	79	16	,	,	PUNCT
ajlsi-2730	79	17	including	include	VERB
ajlsi-2730	79	18	itching	itching	NOUN
ajlsi-2730	79	19	,	,	PUNCT
ajlsi-2730	79	20	scaling	scaling	NOUN
ajlsi-2730	79	21	,	,	PUNCT
ajlsi-2730	79	22	dry	dry	ADJ
ajlsi-2730	79	23	skin	skin	NOUN
ajlsi-2730	79	24	,	,	PUNCT
ajlsi-2730	79	25	and	and	CCONJ
ajlsi-2730	79	26	eczematous	eczematous	ADJ
ajlsi-2730	79	27	lesions	lesion	NOUN
ajlsi-2730	79	28	(	(	PUNCT
ajlsi-2730	79	29	barbati	barbati	PROPN
ajlsi-2730	79	30	et	et	PROPN
ajlsi-2730	79	31	al	al	PROPN
ajlsi-2730	79	32	.	.	PROPN
ajlsi-2730	79	33	,	,	PUNCT
ajlsi-2730	79	34	2021	2021	NUM
ajlsi-2730	79	35	;	;	PUNCT
ajlsi-2730	79	36	cicek	cicek	PROPN
ajlsi-2730	79	37	et	et	PROPN
ajlsi-2730	79	38	al	al	PROPN
ajlsi-2730	79	39	.	.	PROPN
ajlsi-2730	79	40	,	,	PUNCT
ajlsi-2730	79	41	2021	2021	NUM
ajlsi-2730	79	42	;	;	PUNCT
ajlsi-2730	79	43	roda	roda	PROPN
ajlsi-2730	79	44	et	et	PROPN
ajlsi-2730	79	45	al	al	PROPN
ajlsi-2730	79	46	.	.	PROPN
ajlsi-2730	79	47	,	,	PUNCT
ajlsi-2730	79	48	2017	2017	NUM
ajlsi-2730	79	49	)	)	PUNCT
ajlsi-2730	79	50	.	.	PUNCT
ajlsi-2730	80	1	il-17	il-17	AUX
ajlsi-2730	80	2	a	a	DET
ajlsi-2730	80	3	inhibitors	inhibitor	NOUN
ajlsi-2730	80	4	secukinumab	secukinumab	NOUN
ajlsi-2730	80	5	,	,	PUNCT
ajlsi-2730	80	6	which	which	PRON
ajlsi-2730	80	7	resembles	resemble	VERB
ajlsi-2730	80	8	the	the	DET
ajlsi-2730	80	9	inflammatory	inflammatory	ADJ
ajlsi-2730	80	10	profile	profile	NOUN
ajlsi-2730	80	11	of	of	ADP
ajlsi-2730	80	12	ichthyosis	ichthyosis	NOUN
ajlsi-2730	80	13	,	,	PUNCT
ajlsi-2730	80	14	have	have	AUX
ajlsi-2730	80	15	been	be	AUX
ajlsi-2730	80	16	demonstrated	demonstrate	VERB
ajlsi-2730	80	17	in	in	ADP
ajlsi-2730	80	18	clinical	clinical	ADJ
ajlsi-2730	80	19	trials	trial	NOUN
ajlsi-2730	80	20	to	to	PART
ajlsi-2730	80	21	be	be	AUX
ajlsi-2730	80	22	a	a	DET
ajlsi-2730	80	23	safe	safe	ADJ
ajlsi-2730	80	24	and	and	CCONJ
ajlsi-2730	80	25	efficacious	efficacious	ADJ
ajlsi-2730	80	26	treatment	treatment	NOUN
ajlsi-2730	80	27	for	for	ADP
ajlsi-2730	80	28	children	child	NOUN
ajlsi-2730	80	29	with	with	ADP
ajlsi-2730	80	30	psoriasis	psoriasis	NOUN
ajlsi-2730	80	31	.	.	PUNCT
ajlsi-2730	81	1	in	in	ADP
ajlsi-2730	81	2	particular	particular	ADJ
ajlsi-2730	81	3	,	,	PUNCT
ajlsi-2730	81	4	secukinumab	secukinumab	NOUN
ajlsi-2730	81	5	resulted	result	VERB
ajlsi-2730	81	6	in	in	ADP
ajlsi-2730	81	7	a	a	DET
ajlsi-2730	81	8	48	48	NUM
ajlsi-2730	81	9	%	%	NOUN
ajlsi-2730	81	10	decrease	decrease	NOUN
ajlsi-2730	81	11	in	in	ADP
ajlsi-2730	81	12	the	the	DET
ajlsi-2730	81	13	ichthyosisarea	ichthyosisarea	NOUN
ajlsi-2730	81	14	-	-	PUNCT
ajlsi-2730	81	15	severity	severity	NOUN
ajlsi-2730	81	16	-	-	PUNCT
ajlsi-2730	81	17	index	index	NOUN
ajlsi-2730	81	18	score	score	NOUN
ajlsi-2730	81	19	following	follow	VERB
ajlsi-2730	81	20	a	a	DET
ajlsi-2730	81	21	6	6	NUM
ajlsi-2730	81	22	-	-	PUNCT
ajlsi-2730	81	23	month	month	NOUN
ajlsi-2730	81	24	therapy	therapy	NOUN
ajlsi-2730	81	25	term	term	NOUN
ajlsi-2730	81	26	in	in	ADP
ajlsi-2730	81	27	a	a	DET
ajlsi-2730	81	28	young	young	ADJ
ajlsi-2730	81	29	patient	patient	NOUN
ajlsi-2730	81	30	with	with	ADP
ajlsi-2730	81	31	severe	severe	ADJ
ajlsi-2730	81	32	erythrodermic	erythrodermic	ADJ
ajlsi-2730	81	33	ichthyosis	ichthyosis	NOUN
ajlsi-2730	81	34	associated	associate	VERB
ajlsi-2730	81	35	with	with	ADP
ajlsi-2730	81	36	abca12	abca12	NOUN
ajlsi-2730	81	37	deficiency	deficiency	NOUN
ajlsi-2730	81	38	in	in	ADP
ajlsi-2730	81	39	a	a	DET
ajlsi-2730	81	40	therapeutic	therapeutic	ADJ
ajlsi-2730	81	41	trial	trial	NOUN
ajlsi-2730	81	42	.	.	PUNCT
ajlsi-2730	82	1	treatment	treatment	NOUN
ajlsi-2730	82	2	was	be	AUX
ajlsi-2730	82	3	well	well	ADV
ajlsi-2730	82	4	tolerated	tolerate	VERB
ajlsi-2730	82	5	,	,	PUNCT
ajlsi-2730	82	6	and	and	CCONJ
ajlsi-2730	82	7	the	the	DET
ajlsi-2730	82	8	patient	patient	NOUN
ajlsi-2730	82	9	’s	’s	PART
ajlsi-2730	82	10	blood	blood	NOUN
ajlsi-2730	82	11	cytokine	cytokine	NOUN
ajlsi-2730	82	12	profile	profile	NOUN
ajlsi-2730	82	13	consistently	consistently	ADV
ajlsi-2730	82	14	changed	change	VERB
ajlsi-2730	82	15	,	,	PUNCT
ajlsi-2730	82	16	showing	show	VERB
ajlsi-2730	82	17	a	a	DET
ajlsi-2730	82	18	decrease	decrease	NOUN
ajlsi-2730	82	19	in	in	ADP
ajlsi-2730	82	20	proinflammatory	proinflammatory	ADJ
ajlsi-2730	82	21	cytokines	cytokine	NOUN
ajlsi-2730	82	22	and	and	CCONJ
ajlsi-2730	82	23	a	a	DET
ajlsi-2730	82	24	th17	th17	NOUN
ajlsi-2730	82	25	-	-	PUNCT
ajlsi-2730	82	26	skewing	skew	VERB
ajlsi-2730	82	27	(	(	PUNCT
ajlsi-2730	82	28	albela	albela	PROPN
ajlsi-2730	82	29	et	et	PROPN
ajlsi-2730	82	30	al	al	PROPN
ajlsi-2730	82	31	.	.	PROPN
ajlsi-2730	82	32	,	,	PUNCT
ajlsi-2730	82	33	2024	2024	NUM
ajlsi-2730	82	34	;	;	PUNCT
ajlsi-2730	82	35	narbutt	narbutt	PROPN
ajlsi-2730	82	36	et	et	PROPN
ajlsi-2730	82	37	al	al	PROPN
ajlsi-2730	82	38	.	.	PROPN
ajlsi-2730	82	39	,	,	PUNCT
ajlsi-2730	82	40	2023	2023	NUM
ajlsi-2730	82	41	;	;	PUNCT
ajlsi-2730	82	42	yogarajah	yogarajah	PROPN
ajlsi-2730	82	43	et	et	PROPN
ajlsi-2730	82	44	al	al	PROPN
ajlsi-2730	82	45	.	.	PROPN
ajlsi-2730	82	46	,	,	PUNCT
ajlsi-2730	82	47	2021	2021	NUM
ajlsi-2730	82	48	)	)	PUNCT
ajlsi-2730	82	49	.	.	PUNCT
ajlsi-2730	83	1	in	in	ADP
ajlsi-2730	83	2	treating	treat	VERB
ajlsi-2730	83	3	approximately	approximately	ADV
ajlsi-2730	83	4	95	95	NUM
ajlsi-2730	83	5	%	%	NOUN
ajlsi-2730	83	6	of	of	ADP
ajlsi-2730	83	7	patients	patient	NOUN
ajlsi-2730	83	8	with	with	ADP
ajlsi-2730	83	9	pediatric	pediatric	ADJ
ajlsi-2730	83	10	ichthyosis	ichthyosis	NOUN
ajlsi-2730	83	11	vulgaris	vulgaris	NOUN
ajlsi-2730	83	12	,	,	PUNCT
ajlsi-2730	83	13	ixekizumab	ixekizumab	NOUN
ajlsi-2730	83	14	has	have	AUX
ajlsi-2730	83	15	demonstrated	demonstrate	VERB
ajlsi-2730	83	16	longterm	longterm	ADJ
ajlsi-2730	83	17	safety	safety	NOUN
ajlsi-2730	83	18	and	and	CCONJ
ajlsi-2730	83	19	efficacy	efficacy	NOUN
ajlsi-2730	83	20	in	in	ADP
ajlsi-2730	83	21	decreasing	decrease	VERB
ajlsi-2730	83	22	dry	dry	ADJ
ajlsi-2730	83	23	scales	scale	NOUN
ajlsi-2730	83	24	.	.	PUNCT
ajlsi-2730	84	1	changes	change	NOUN
ajlsi-2730	84	2	in	in	ADP
ajlsi-2730	84	3	profilagrin	profilagrin	NOUN
ajlsi-2730	84	4	expression	expression	NOUN
ajlsi-2730	84	5	tackle	tackle	VERB
ajlsi-2730	84	6	the	the	DET
ajlsi-2730	84	7	underlying	underlie	VERB
ajlsi-2730	84	8	pathology	pathology	NOUN
ajlsi-2730	84	9	(	(	PUNCT
ajlsi-2730	84	10	pontone	pontone	NOUN
ajlsi-2730	84	11	et	et	PROPN
ajlsi-2730	84	12	al	al	PROPN
ajlsi-2730	84	13	.	.	PROPN
ajlsi-2730	84	14	,	,	PUNCT
ajlsi-2730	84	15	2022	2022	NUM
ajlsi-2730	84	16	)	)	PUNCT
ajlsi-2730	84	17	.	.	PUNCT
ajlsi-2730	85	1	dupilumab	dupilumab	NOUN
ajlsi-2730	85	2	reduces	reduce	VERB
ajlsi-2730	85	3	inflammation	inflammation	NOUN
ajlsi-2730	85	4	and	and	CCONJ
ajlsi-2730	85	5	pruritus	pruritus	NOUN
ajlsi-2730	85	6	in	in	ADP
ajlsi-2730	85	7	patients	patient	NOUN
ajlsi-2730	85	8	with	with	ADP
ajlsi-2730	85	9	ichthyosis	ichthyosis	NOUN
ajlsi-2730	85	10	by	by	ADP
ajlsi-2730	85	11	inhibiting	inhibit	VERB
ajlsi-2730	85	12	interleukin-4	interleukin-4	PROPN
ajlsi-2730	85	13	and	and	CCONJ
ajlsi-2730	85	14	interleukin-13	interleukin-13	PROPN
ajlsi-2730	85	15	signaling	signal	VERB
ajlsi-2730	85	16	.	.	PUNCT
ajlsi-2730	86	1	studies	study	NOUN
ajlsi-2730	86	2	indicate	indicate	VERB
ajlsi-2730	86	3	that	that	DET
ajlsi-2730	86	4	netherton	netherton	NOUN
ajlsi-2730	86	5	syndrome	syndrome	NOUN
ajlsi-2730	86	6	and	and	CCONJ
ajlsi-2730	86	7	bullous	bullous	ADJ
ajlsi-2730	86	8	congenital	congenital	ADJ
ajlsi-2730	86	9	ichthyosiform	ichthyosiform	NOUN
ajlsi-2730	86	10	erythroderma	erythroderma	NOUN
ajlsi-2730	86	11	bcie	bcie	NOUN
ajlsi-2730	86	12	can	can	AUX
ajlsi-2730	86	13	be	be	AUX
ajlsi-2730	86	14	treated	treat	VERB
ajlsi-2730	86	15	well	well	ADV
ajlsi-2730	86	16	and	and	CCONJ
ajlsi-2730	86	17	that	that	SCONJ
ajlsi-2730	86	18	managing	manage	VERB
ajlsi-2730	86	19	ichthyosis	ichthyosis	NOUN
ajlsi-2730	86	20	in	in	ADP
ajlsi-2730	86	21	children	child	NOUN
ajlsi-2730	86	22	may	may	AUX
ajlsi-2730	86	23	be	be	AUX
ajlsi-2730	86	24	possible	possible	ADJ
ajlsi-2730	86	25	(	(	PUNCT
ajlsi-2730	86	26	afshan	afshan	NOUN
ajlsi-2730	86	27	&	&	CCONJ
ajlsi-2730	86	28	kelbel	kelbel	PROPN
ajlsi-2730	86	29	,	,	PUNCT
ajlsi-2730	86	30	2019	2019	NUM
ajlsi-2730	86	31	;	;	PUNCT
ajlsi-2730	86	32	almuhanna	almuhanna	NOUN
ajlsi-2730	86	33	,	,	PUNCT
ajlsi-2730	86	34	alrashidi	alrashidi	NOUN
ajlsi-2730	86	35	,	,	PUNCT
ajlsi-2730	86	36	et	et	PROPN
ajlsi-2730	86	37	al	al	PROPN
ajlsi-2730	86	38	.	.	PROPN
ajlsi-2730	86	39	,	,	PUNCT
ajlsi-2730	86	40	2023	2023	NUM
ajlsi-2730	86	41	;	;	PUNCT
ajlsi-2730	86	42	martin	martin	PROPN
ajlsi-2730	86	43	-	-	PUNCT
ajlsi-2730	86	44	garcía	garcía	PROPN
ajlsi-2730	86	45	et	et	PROPN
ajlsi-2730	86	46	al	al	PROPN
ajlsi-2730	86	47	.	.	PROPN
ajlsi-2730	86	48	,	,	PUNCT
ajlsi-2730	86	49	2023	2023	NUM
ajlsi-2730	86	50	;	;	PUNCT
ajlsi-2730	87	1	olbrich	olbrich	PROPN
ajlsi-2730	87	2	et	et	PROPN
ajlsi-2730	87	3	al	al	PROPN
ajlsi-2730	87	4	.	.	PROPN
ajlsi-2730	87	5	,	,	PUNCT
ajlsi-2730	87	6	2023	2023	NUM
ajlsi-2730	87	7	)	)	PUNCT
ajlsi-2730	87	8	.	.	PUNCT
ajlsi-2730	88	1	ustekinumab	ustekinumab	NOUN
ajlsi-2730	88	2	has	have	AUX
ajlsi-2730	88	3	been	be	AUX
ajlsi-2730	88	4	investigated	investigate	VERB
ajlsi-2730	88	5	for	for	ADP
ajlsi-2730	88	6	the	the	DET
ajlsi-2730	88	7	treatment	treatment	NOUN
ajlsi-2730	88	8	of	of	ADP
ajlsi-2730	88	9	ichthyosis	ichthyosis	NOUN
ajlsi-2730	88	10	in	in	ADP
ajlsi-2730	88	11	pediatric	pediatric	ADJ
ajlsi-2730	88	12	patients	patient	NOUN
ajlsi-2730	88	13	,	,	PUNCT
ajlsi-2730	88	14	particularly	particularly	ADV
ajlsi-2730	88	15	in	in	ADP
ajlsi-2730	88	16	the	the	DET
ajlsi-2730	88	17	case	case	NOUN
ajlsi-2730	88	18	of	of	ADP
ajlsi-2730	88	19	a	a	DET
ajlsi-2730	88	20	15	15	NUM
ajlsi-2730	88	21	-	-	PUNCT
ajlsi-2730	88	22	year	year	NOUN
ajlsi-2730	88	23	-	-	PUNCT
ajlsi-2730	88	24	old	old	ADJ
ajlsi-2730	88	25	boy	boy	NOUN
ajlsi-2730	88	26	with	with	ADP
ajlsi-2730	88	27	harlequin	harlequin	PROPN
ajlsi-2730	88	28	ichthyosis	ichthyosis	NOUN
ajlsi-2730	88	29	(	(	PUNCT
ajlsi-2730	88	30	hi	hi	INTJ
ajlsi-2730	88	31	)	)	PUNCT
ajlsi-2730	88	32	.	.	PUNCT
ajlsi-2730	89	1	after	after	ADP
ajlsi-2730	89	2	one	one	NUM
ajlsi-2730	89	3	month	month	NOUN
ajlsi-2730	89	4	of	of	ADP
ajlsi-2730	89	5	treatment	treatment	NOUN
ajlsi-2730	89	6	,	,	PUNCT
ajlsi-2730	89	7	the	the	DET
ajlsi-2730	89	8	off	off	ADP
ajlsi-2730	89	9	-	-	PUNCT
ajlsi-2730	89	10	label	label	NOUN
ajlsi-2730	89	11	ustekinumab	ustekinumab	NOUN
ajlsi-2730	89	12	trial	trial	NOUN
ajlsi-2730	89	13	revealed	reveal	VERB
ajlsi-2730	89	14	a	a	DET
ajlsi-2730	89	15	little	little	ADJ
ajlsi-2730	89	16	improvement	improvement	NOUN
ajlsi-2730	89	17	in	in	ADP
ajlsi-2730	89	18	erythema	erythema	PROPN
ajlsi-2730	89	19	.	.	PUNCT
ajlsi-2730	90	1	ustekinumab	ustekinumab	NOUN
ajlsi-2730	90	2	was	be	AUX
ajlsi-2730	90	3	removed	remove	VERB
ajlsi-2730	90	4	from	from	ADP
ajlsi-2730	90	5	the	the	DET
ajlsi-2730	90	6	regimen	regiman	NOUN
ajlsi-2730	90	7	after	after	ADP
ajlsi-2730	90	8	a	a	DET
ajlsi-2730	90	9	year	year	NOUN
ajlsi-2730	90	10	since	since	SCONJ
ajlsi-2730	90	11	it	it	PRON
ajlsi-2730	90	12	did	do	AUX
ajlsi-2730	90	13	not	not	PART
ajlsi-2730	90	14	result	result	VERB
ajlsi-2730	90	15	in	in	ADP
ajlsi-2730	90	16	a	a	DET
ajlsi-2730	90	17	meaningful	meaningful	ADJ
ajlsi-2730	90	18	response	response	NOUN
ajlsi-2730	90	19	to	to	ADP
ajlsi-2730	90	20	treatment	treatment	NOUN
ajlsi-2730	90	21	.	.	PUNCT
ajlsi-2730	91	1	however	however	ADV
ajlsi-2730	91	2	,	,	PUNCT
ajlsi-2730	91	3	ustekinumab	ustekinumab	NOUN
ajlsi-2730	91	4	may	may	AUX
ajlsi-2730	91	5	be	be	AUX
ajlsi-2730	91	6	a	a	DET
ajlsi-2730	91	7	viable	viable	ADJ
ajlsi-2730	91	8	therapeutic	therapeutic	ADJ
ajlsi-2730	91	9	option	option	NOUN
ajlsi-2730	91	10	for	for	ADP
ajlsi-2730	91	11	other	other	ADJ
ajlsi-2730	91	12	ichthyotic	ichthyotic	ADJ
ajlsi-2730	91	13	disorders	disorder	NOUN
ajlsi-2730	91	14	(	(	PUNCT
ajlsi-2730	91	15	almuhanna	almuhanna	NOUN
ajlsi-2730	91	16	,	,	PUNCT
ajlsi-2730	91	17	alasmari	alasmari	PROPN
ajlsi-2730	91	18	,	,	PUNCT
ajlsi-2730	91	19	et	et	PROPN
ajlsi-2730	91	20	al	al	PROPN
ajlsi-2730	91	21	.	.	PROPN
ajlsi-2730	91	22	,	,	PUNCT
ajlsi-2730	91	23	2023	2023	NUM
ajlsi-2730	91	24	)	)	PUNCT
ajlsi-2730	91	25	.	.	PUNCT
ajlsi-2730	92	1	materials	material	NOUN
ajlsi-2730	92	2	and	and	CCONJ
ajlsi-2730	92	3	methods	method	NOUN
ajlsi-2730	92	4	study	study	NOUN
ajlsi-2730	92	5	design	design	VERB
ajlsi-2730	92	6	the	the	DET
ajlsi-2730	92	7	present	present	ADJ
ajlsi-2730	92	8	research	research	NOUN
ajlsi-2730	92	9	study	study	NOUN
ajlsi-2730	92	10	was	be	AUX
ajlsi-2730	92	11	retrospective	retrospective	ADJ
ajlsi-2730	92	12	to	to	PART
ajlsi-2730	92	13	examine	examine	VERB
ajlsi-2730	92	14	the	the	DET
ajlsi-2730	92	15	safety	safety	NOUN
ajlsi-2730	92	16	and	and	CCONJ
ajlsi-2730	92	17	efficacy	efficacy	NOUN
ajlsi-2730	92	18	of	of	ADP
ajlsi-2730	92	19	immune	immune	ADJ
ajlsi-2730	92	20	system	system	NOUN
ajlsi-2730	92	21	inhibitors	inhibitor	NOUN
ajlsi-2730	92	22	that	that	PRON
ajlsi-2730	92	23	target	target	VERB
ajlsi-2730	92	24	tnf	tnf	PROPN
ajlsi-2730	92	25	-	-	PUNCT
ajlsi-2730	92	26	alpha	alpha	NOUN
ajlsi-2730	92	27	,	,	PUNCT
ajlsi-2730	92	28	il-17a	il-17a	PROPN
ajlsi-2730	92	29	,	,	PUNCT
ajlsi-2730	92	30	il-4	il-4	X
ajlsi-2730	92	31	,	,	PUNCT
ajlsi-2730	92	32	and	and	CCONJ
ajlsi-2730	92	33	il-12	il-12	NOUN
ajlsi-2730	92	34	in	in	ADP
ajlsi-2730	92	35	pediatric	pediatric	ADJ
ajlsi-2730	92	36	ichthyosis	ichthyosis	NOUN
ajlsi-2730	92	37	treatment	treatment	NOUN
ajlsi-2730	92	38	.	.	PUNCT
ajlsi-2730	93	1	study	study	NOUN
ajlsi-2730	93	2	setting	set	VERB
ajlsi-2730	93	3	duration	duration	NOUN
ajlsi-2730	93	4	the	the	DET
ajlsi-2730	93	5	current	current	ADJ
ajlsi-2730	93	6	study	study	NOUN
ajlsi-2730	93	7	was	be	AUX
ajlsi-2730	93	8	conducted	conduct	VERB
ajlsi-2730	93	9	on	on	ADP
ajlsi-2730	93	10	30	30	NUM
ajlsi-2730	93	11	pediatric	pediatric	ADJ
ajlsi-2730	93	12	patients	patient	NOUN
ajlsi-2730	93	13	(	(	PUNCT
ajlsi-2730	93	14	ages	age	NOUN
ajlsi-2730	93	15	6	6	NUM
ajlsi-2730	93	16	-	-	SYM
ajlsi-2730	93	17	12	12	NUM
ajlsi-2730	93	18	years	year	NOUN
ajlsi-2730	93	19	)	)	PUNCT
ajlsi-2730	93	20	diagnosed	diagnose	VERB
ajlsi-2730	93	21	with	with	ADP
ajlsi-2730	93	22	different	different	ADJ
ajlsi-2730	93	23	types	type	NOUN
ajlsi-2730	93	24	of	of	ADP
ajlsi-2730	93	25	ichthyosis	ichthyosis	NOUN
ajlsi-2730	93	26	skin	skin	NOUN
ajlsi-2730	93	27	diseases	disease	NOUN
ajlsi-2730	93	28	at	at	ADP
ajlsi-2730	93	29	tertiary	tertiary	ADJ
ajlsi-2730	93	30	care	care	NOUN
ajlsi-2730	93	31	pediatric	pediatric	ADJ
ajlsi-2730	93	32	dermatology	dermatology	NOUN
ajlsi-2730	93	33	hospitals	hospital	NOUN
ajlsi-2730	93	34	in	in	ADP
ajlsi-2730	93	35	uae	uae	PROPN
ajlsi-2730	93	36	for	for	ADP
ajlsi-2730	93	37	5	5	NUM
ajlsi-2730	93	38	months	month	NOUN
ajlsi-2730	93	39	from	from	ADP
ajlsi-2730	93	40	november	november	PROPN
ajlsi-2730	93	41	to	to	ADP
ajlsi-2730	93	42	february	february	PROPN
ajlsi-2730	93	43	2024	2024	NUM
ajlsi-2730	93	44	.	.	PUNCT
ajlsi-2730	94	1	participants	participant	NOUN
ajlsi-2730	94	2	inclusion	inclusion	NOUN
ajlsi-2730	94	3	criteria	criterion	NOUN
ajlsi-2730	94	4	➢	➢	VERB
ajlsi-2730	94	5	patients	patient	NOUN
ajlsi-2730	94	6	with	with	ADP
ajlsi-2730	94	7	ichthyosis	ichthyosis	NOUN
ajlsi-2730	94	8	between	between	ADP
ajlsi-2730	94	9	the	the	DET
ajlsi-2730	94	10	ages	age	NOUN
ajlsi-2730	94	11	of	of	ADP
ajlsi-2730	94	12	6	6	NUM
ajlsi-2730	94	13	and	and	CCONJ
ajlsi-2730	94	14	12	12	NUM
ajlsi-2730	94	15	who	who	PRON
ajlsi-2730	94	16	satisfied	satisfy	VERB
ajlsi-2730	94	17	the	the	DET
ajlsi-2730	94	18	study	study	NOUN
ajlsi-2730	94	19	’s	’s	PART
ajlsi-2730	94	20	criteria	criterion	NOUN
ajlsi-2730	94	21	and	and	CCONJ
ajlsi-2730	94	22	were	be	AUX
ajlsi-2730	94	23	verified	verify	VERB
ajlsi-2730	94	24	by	by	ADP
ajlsi-2730	94	25	the	the	DET
ajlsi-2730	94	26	patients	patient	NOUN
ajlsi-2730	94	27	’	'	PUNCT
ajlsi-2730	94	28	database	database	NOUN
ajlsi-2730	94	29	were	be	AUX
ajlsi-2730	94	30	included	include	VERB
ajlsi-2730	94	31	.	.	PUNCT
ajlsi-2730	95	1	➢	➢	VERB
ajlsi-2730	95	2	subjects	subject	NOUN
ajlsi-2730	95	3	with	with	ADP
ajlsi-2730	95	4	a	a	DET
ajlsi-2730	95	5	recent	recent	ADJ
ajlsi-2730	95	6	diagnosis	diagnosis	NOUN
ajlsi-2730	95	7	or	or	CCONJ
ajlsi-2730	95	8	those	those	PRON
ajlsi-2730	95	9	with	with	ADP
ajlsi-2730	95	10	a	a	DET
ajlsi-2730	95	11	previous	previous	ADJ
ajlsi-2730	95	12	diagnosis	diagnosis	NOUN
ajlsi-2730	95	13	were	be	AUX
ajlsi-2730	95	14	included	include	VERB
ajlsi-2730	95	15	in	in	ADP
ajlsi-2730	95	16	the	the	DET
ajlsi-2730	95	17	follow	follow	NOUN
ajlsi-2730	95	18	-	-	PUNCT
ajlsi-2730	95	19	up	up	NOUN
ajlsi-2730	95	20	.	.	PUNCT
ajlsi-2730	96	1	➢	➢	VERB
ajlsi-2730	96	2	clinical	clinical	ADJ
ajlsi-2730	96	3	information	information	NOUN
ajlsi-2730	96	4	included	include	VERB
ajlsi-2730	96	5	key	key	ADJ
ajlsi-2730	96	6	ichthyosis	ichthyosis	NOUN
ajlsi-2730	96	7	conditions	condition	NOUN
ajlsi-2730	96	8	such	such	ADJ
ajlsi-2730	96	9	as	as	ADP
ajlsi-2730	96	10	lamellar	lamellar	ADJ
ajlsi-2730	96	11	,	,	PUNCT
ajlsi-2730	96	12	x	x	ADJ
ajlsi-2730	96	13	-	-	VERB
ajlsi-2730	96	14	linked	link	VERB
ajlsi-2730	96	15	recessive	recessive	ADJ
ajlsi-2730	96	16	,	,	PUNCT
ajlsi-2730	96	17	and	and	CCONJ
ajlsi-2730	96	18	vulgaris	vulgaris	NOUN
ajlsi-2730	96	19	ichthyosis	ichthyosis	NOUN
ajlsi-2730	96	20	.	.	PUNCT
ajlsi-2730	97	1	exclusion	exclusion	NOUN
ajlsi-2730	97	2	criteria	criterion	NOUN
ajlsi-2730	97	3	➢	➢	VERB
ajlsi-2730	97	4	the	the	DET
ajlsi-2730	97	5	present	present	ADJ
ajlsi-2730	97	6	research	research	NOUN
ajlsi-2730	97	7	study	study	NOUN
ajlsi-2730	97	8	eliminated	eliminate	VERB
ajlsi-2730	97	9	patients	patient	NOUN
ajlsi-2730	97	10	who	who	PRON
ajlsi-2730	97	11	declined	decline	VERB
ajlsi-2730	97	12	to	to	PART
ajlsi-2730	97	13	participate	participate	VERB
ajlsi-2730	97	14	or	or	CCONJ
ajlsi-2730	97	15	had	have	AUX
ajlsi-2730	97	16	missing	miss	VERB
ajlsi-2730	97	17	data	datum	NOUN
ajlsi-2730	97	18	.	.	PUNCT
ajlsi-2730	98	1	intervention	intervention	NOUN
ajlsi-2730	98	2	➢	➢	VERB
ajlsi-2730	98	3	previous	previous	ADJ
ajlsi-2730	98	4	research	research	NOUN
ajlsi-2730	98	5	studies	study	NOUN
ajlsi-2730	98	6	found	find	VERB
ajlsi-2730	98	7	that	that	SCONJ
ajlsi-2730	98	8	tnf	tnf	PROPN
ajlsi-2730	98	9	-	-	PUNCT
ajlsi-2730	98	10	alpha	alpha	NOUN
ajlsi-2730	98	11	was	be	AUX
ajlsi-2730	98	12	elevated	elevate	VERB
ajlsi-2730	98	13	in	in	ADP
ajlsi-2730	98	14	netherton	netherton	NOUN
ajlsi-2730	98	15	syndrome	syndrome	NOUN
ajlsi-2730	98	16	compared	compare	VERB
ajlsi-2730	98	17	to	to	ADP
ajlsi-2730	98	18	psoriasis	psoriasis	NOUN
ajlsi-2730	98	19	and	and	CCONJ
ajlsi-2730	98	20	atopic	atopic	NOUN
ajlsi-2730	98	21	dermatitis	dermatitis	NOUN
ajlsi-2730	98	22	,	,	PUNCT
ajlsi-2730	98	23	but	but	CCONJ
ajlsi-2730	98	24	it	it	PRON
ajlsi-2730	98	25	was	be	AUX
ajlsi-2730	98	26	still	still	ADV
ajlsi-2730	98	27	lower	low	ADJ
ajlsi-2730	98	28	than	than	ADP
ajlsi-2730	98	29	in	in	ADP
ajlsi-2730	98	30	ichthyosis	ichthyosis	NOUN
ajlsi-2730	98	31	.	.	PUNCT
ajlsi-2730	99	1	together	together	ADV
ajlsi-2730	99	2	,	,	PUNCT
ajlsi-2730	99	3	tnf	tnf	PROPN
ajlsi-2730	99	4	-	-	PUNCT
ajlsi-2730	99	5	alpha	alpha	NOUN
ajlsi-2730	99	6	and	and	CCONJ
ajlsi-2730	99	7	il-17	il-17	PART
ajlsi-2730	99	8	activate	activate	VERB
ajlsi-2730	99	9	genes	gene	NOUN
ajlsi-2730	99	10	and	and	CCONJ
ajlsi-2730	99	11	markers	marker	NOUN
ajlsi-2730	99	12	connected	connect	VERB
ajlsi-2730	99	13	to	to	ADP
ajlsi-2730	99	14	il-17	il-17	PRON
ajlsi-2730	99	15	,	,	PUNCT
ajlsi-2730	99	16	so	so	ADV
ajlsi-2730	99	17	the	the	DET
ajlsi-2730	99	18	main	main	ADJ
ajlsi-2730	99	19	cytokine	cytokine	NOUN
ajlsi-2730	99	20	of	of	ADP
ajlsi-2730	99	21	the	the	DET
ajlsi-2730	99	22	th17	th17	PROPN
ajlsi-2730	99	23	pathway	pathway	NOUN
ajlsi-2730	99	24	,	,	PUNCT
ajlsi-2730	99	25	il-17a	il-17a	PROPN
ajlsi-2730	99	26	,	,	PUNCT
ajlsi-2730	99	27	sharply	sharply	ADV
ajlsi-2730	99	28	increases	increase	VERB
ajlsi-2730	99	29	during	during	ADP
ajlsi-2730	99	30	ichthyosis	ichthyosis	NOUN
ajlsi-2730	99	31	.	.	PUNCT
ajlsi-2730	100	1	idh	idh	NOUN
ajlsi-2730	100	2	-	-	PUNCT
ajlsi-2730	100	3	related	relate	VERB
ajlsi-2730	100	4	th2	th2	PROPN
ajlsi-2730	100	5	cytokine	cytokine	NOUN
ajlsi-2730	100	6	il-4	il-4	PART
ajlsi-2730	100	7	expression	expression	NOUN
ajlsi-2730	100	8	levels	level	NOUN
ajlsi-2730	100	9	are	be	AUX
ajlsi-2730	100	10	comparable	comparable	ADJ
ajlsi-2730	100	11	to	to	ADP
ajlsi-2730	100	12	controls	control	NOUN
ajlsi-2730	100	13	in	in	ADP
ajlsi-2730	100	14	ichthyosis	ichthyosis	NOUN
ajlsi-2730	100	15	.	.	PUNCT
ajlsi-2730	101	1	furthermore	furthermore	ADV
ajlsi-2730	101	2	,	,	PUNCT
ajlsi-2730	101	3	engaged	engage	VERB
ajlsi-2730	101	4	in	in	ADP
ajlsi-2730	101	5	the	the	DET
ajlsi-2730	101	6	immunological	immunological	ADJ
ajlsi-2730	101	7	profile	profile	NOUN
ajlsi-2730	101	8	of	of	ADP
ajlsi-2730	101	9	ichthyosis	ichthyosis	NOUN
ajlsi-2730	101	10	,	,	PUNCT
ajlsi-2730	101	11	il-12	il-12	NOUN
ajlsi-2730	101	12	also	also	ADV
ajlsi-2730	101	13	impacts	impact	VERB
ajlsi-2730	101	14	th1	th1	PROPN
ajlsi-2730	101	15	immune	immune	ADJ
ajlsi-2730	101	16	responses	response	NOUN
ajlsi-2730	101	17	.	.	PUNCT
ajlsi-2730	102	1	key	key	ADJ
ajlsi-2730	102	2	cytokine	cytokine	NOUN
ajlsi-2730	102	3	of	of	ADP
ajlsi-2730	102	4	ichthyosis	ichthyosis	NOUN
ajlsi-2730	102	5	il-17	il-17	NOUN
ajlsi-2730	102	6	-	-	PUNCT
ajlsi-2730	102	7	a	a	DET
ajlsi-2730	102	8	inhibition	inhibition	NOUN
ajlsi-2730	102	9	➢	➢	NOUN
ajlsi-2730	102	10	il-17	il-17	AUX
ajlsi-2730	102	11	a	a	PRON
ajlsi-2730	102	12	is	be	AUX
ajlsi-2730	102	13	the	the	DET
ajlsi-2730	102	14	primary	primary	ADJ
ajlsi-2730	102	15	cytokine	cytokine	NOUN
ajlsi-2730	102	16	responsible	responsible	ADJ
ajlsi-2730	102	17	for	for	ADP
ajlsi-2730	102	18	inducing	induce	VERB
ajlsi-2730	102	19	an	an	DET
ajlsi-2730	102	20	immune	immune	ADJ
ajlsi-2730	102	21	response	response	NOUN
ajlsi-2730	102	22	by	by	ADP
ajlsi-2730	102	23	activating	activate	VERB
ajlsi-2730	102	24	genes	gene	NOUN
ajlsi-2730	102	25	and	and	CCONJ
ajlsi-2730	102	26	infectious	infectious	ADJ
ajlsi-2730	102	27	or	or	CCONJ
ajlsi-2730	102	28	inflammatory	inflammatory	ADJ
ajlsi-2730	102	29	markers	marker	NOUN
ajlsi-2730	102	30	.	.	PUNCT
ajlsi-2730	103	1	➢	➢	VERB
ajlsi-2730	103	2	the	the	DET
ajlsi-2730	103	3	primary	primary	ADJ
ajlsi-2730	103	4	focus	focus	NOUN
ajlsi-2730	103	5	of	of	ADP
ajlsi-2730	103	6	this	this	DET
ajlsi-2730	103	7	study	study	NOUN
ajlsi-2730	103	8	was	be	AUX
ajlsi-2730	103	9	to	to	PART
ajlsi-2730	103	10	inhibit	inhibit	VERB
ajlsi-2730	103	11	il17	il17	PROPN
ajlsi-2730	103	12	-	-	PUNCT
ajlsi-2730	103	13	a	a	NOUN
ajlsi-2730	103	14	in	in	ADP
ajlsi-2730	103	15	order	order	NOUN
ajlsi-2730	103	16	to	to	PART
ajlsi-2730	103	17	lessen	lessen	VERB
ajlsi-2730	103	18	the	the	DET
ajlsi-2730	103	19	inflammatory	inflammatory	ADJ
ajlsi-2730	103	20	and	and	CCONJ
ajlsi-2730	103	21	allergic	allergic	ADJ
ajlsi-2730	103	22	symptoms	symptom	NOUN
ajlsi-2730	103	23	associated	associate	VERB
ajlsi-2730	103	24	with	with	ADP
ajlsi-2730	103	25	all	all	DET
ajlsi-2730	103	26	three	three	NUM
ajlsi-2730	103	27	types	type	NOUN
ajlsi-2730	103	28	of	of	ADP
ajlsi-2730	103	29	pediatric	pediatric	ADJ
ajlsi-2730	103	30	ichthyosis	ichthyosis	NOUN
ajlsi-2730	103	31	.	.	PUNCT
ajlsi-2730	104	1	➢	➢	X
ajlsi-2730	104	2	il-17a	il-17a	PROPN
ajlsi-2730	104	3	inhibitors	inhibitor	NOUN
ajlsi-2730	104	4	,	,	PUNCT
ajlsi-2730	104	5	including	include	VERB
ajlsi-2730	104	6	secukinumab	secukinumab	NOUN
ajlsi-2730	104	7	,	,	PUNCT
ajlsi-2730	104	8	ixekizumab	ixekizumab	NOUN
ajlsi-2730	104	9	,	,	PUNCT
ajlsi-2730	104	10	and	and	CCONJ
ajlsi-2730	104	11	brodalumab	brodalumab	NOUN
ajlsi-2730	104	12	,	,	PUNCT
ajlsi-2730	104	13	were	be	AUX
ajlsi-2730	104	14	administered	administer	VERB
ajlsi-2730	104	15	to	to	ADP
ajlsi-2730	104	16	patients	patient	NOUN
ajlsi-2730	104	17	6	6	NUM
ajlsi-2730	104	18	to	to	PART
ajlsi-2730	104	19	12	12	NUM
ajlsi-2730	104	20	years	year	NOUN
ajlsi-2730	104	21	old	old	ADJ
ajlsi-2730	104	22	,	,	PUNCT
ajlsi-2730	104	23	according	accord	VERB
ajlsi-2730	104	24	to	to	ADP
ajlsi-2730	104	25	their	their	PRON
ajlsi-2730	104	26	body	body	NOUN
ajlsi-2730	104	27	mass	mass	NOUN
ajlsi-2730	104	28	index	index	NOUN
ajlsi-2730	104	29	,	,	PUNCT
ajlsi-2730	104	30	who	who	PRON
ajlsi-2730	104	31	had	have	AUX
ajlsi-2730	104	32	been	be	AUX
ajlsi-2730	104	33	diagnosed	diagnose	VERB
ajlsi-2730	104	34	with	with	ADP
ajlsi-2730	104	35	multiple	multiple	ADJ
ajlsi-2730	104	36	types	type	NOUN
ajlsi-2730	104	37	of	of	ADP
ajlsi-2730	104	38	ichthyosis	ichthyosis	NOUN
ajlsi-2730	104	39	,	,	PUNCT
ajlsi-2730	104	40	such	such	ADJ
ajlsi-2730	104	41	as	as	ADP
ajlsi-2730	104	42	vulgaris	vulgaris	NOUN
ajlsi-2730	104	43	,	,	PUNCT
ajlsi-2730	104	44	lamellar	lamellar	NOUN
ajlsi-2730	104	45	,	,	PUNCT
ajlsi-2730	104	46	and	and	CCONJ
ajlsi-2730	104	47	x	x	PUNCT
ajlsi-2730	104	48	linked	link	VERB
ajlsi-2730	104	49	.	.	PUNCT
ajlsi-2730	105	1	pa	pa	PROPN
ajlsi-2730	105	2	ge	ge	PROPN
ajlsi-2730	105	3	72	72	NUM
ajlsi-2730	105	4	https://journals.e-palli.com/home/index.php/ajlsi	https://journals.e-palli.com/home/index.php/ajlsi	PROPN
ajlsi-2730	105	5	am	am	NOUN
ajlsi-2730	105	6	.	.	PUNCT
ajlsi-2730	106	1	j.	j.	PROPN
ajlsi-2730	106	2	life	life	PROPN
ajlsi-2730	106	3	sci	sci	PROPN
ajlsi-2730	106	4	.	.	PUNCT
ajlsi-2730	106	5	innov	innov	PROPN
ajlsi-2730	106	6	.	.	PUNCT
ajlsi-2730	107	1	3(1	3(1	NUM
ajlsi-2730	107	2	)	)	PUNCT
ajlsi-2730	107	3	69	69	NUM
ajlsi-2730	107	4	-	-	SYM
ajlsi-2730	107	5	74	74	NUM
ajlsi-2730	107	6	,	,	PUNCT
ajlsi-2730	107	7	2024	2024	NUM
ajlsi-2730	107	8	outcome	outcome	NOUN
ajlsi-2730	107	9	measures	measure	NOUN
ajlsi-2730	107	10	➢	➢	VERB
ajlsi-2730	107	11	in	in	ADP
ajlsi-2730	107	12	the	the	DET
ajlsi-2730	107	13	result	result	NOUN
ajlsi-2730	107	14	,	,	PUNCT
ajlsi-2730	107	15	it	it	PRON
ajlsi-2730	107	16	was	be	AUX
ajlsi-2730	107	17	found	find	VERB
ajlsi-2730	107	18	that	that	SCONJ
ajlsi-2730	107	19	after	after	ADP
ajlsi-2730	107	20	5	5	NUM
ajlsi-2730	107	21	months	month	NOUN
ajlsi-2730	107	22	of	of	ADP
ajlsi-2730	107	23	therapy	therapy	NOUN
ajlsi-2730	107	24	,	,	PUNCT
ajlsi-2730	107	25	the	the	DET
ajlsi-2730	107	26	patients	patient	NOUN
ajlsi-2730	107	27	who	who	PRON
ajlsi-2730	107	28	were	be	AUX
ajlsi-2730	107	29	given	give	VERB
ajlsi-2730	107	30	secukinumab	secukinumab	NOUN
ajlsi-2730	107	31	provided	provide	VERB
ajlsi-2730	107	32	positive	positive	ADJ
ajlsi-2730	107	33	results	result	NOUN
ajlsi-2730	107	34	,	,	PUNCT
ajlsi-2730	107	35	and	and	CCONJ
ajlsi-2730	107	36	the	the	DET
ajlsi-2730	107	37	patient	patient	NOUN
ajlsi-2730	107	38	’s	’s	PART
ajlsi-2730	107	39	ichthyosis	ichthyosis	NOUN
ajlsi-2730	107	40	area	area	NOUN
ajlsi-2730	107	41	severity	severity	NOUN
ajlsi-2730	107	42	index	index	NOUN
ajlsi-2730	107	43	score	score	NOUN
ajlsi-2730	107	44	decreased	decrease	VERB
ajlsi-2730	107	45	by	by	ADP
ajlsi-2730	107	46	45	45	NUM
ajlsi-2730	107	47	to	to	PART
ajlsi-2730	107	48	50	50	NUM
ajlsi-2730	107	49	percent	percent	NOUN
ajlsi-2730	107	50	,	,	PUNCT
ajlsi-2730	107	51	and	and	CCONJ
ajlsi-2730	107	52	it	it	PRON
ajlsi-2730	107	53	significantly	significantly	ADV
ajlsi-2730	107	54	reduced	reduce	VERB
ajlsi-2730	107	55	the	the	DET
ajlsi-2730	107	56	proinflammatory	proinflammatory	ADJ
ajlsi-2730	107	57	rate	rate	NOUN
ajlsi-2730	107	58	of	of	ADP
ajlsi-2730	107	59	cytokines	cytokine	NOUN
ajlsi-2730	107	60	against	against	ADP
ajlsi-2730	107	61	the	the	DET
ajlsi-2730	107	62	control	control	NOUN
ajlsi-2730	107	63	group	group	NOUN
ajlsi-2730	107	64	,	,	PUNCT
ajlsi-2730	107	65	which	which	PRON
ajlsi-2730	107	66	was	be	AUX
ajlsi-2730	107	67	given	give	VERB
ajlsi-2730	107	68	with	with	ADP
ajlsi-2730	107	69	placebo	placebo	NOUN
ajlsi-2730	107	70	.	.	PUNCT
ajlsi-2730	108	1	➢	➢	PROPN
ajlsi-2730	108	2	on	on	ADP
ajlsi-2730	108	3	the	the	DET
ajlsi-2730	108	4	other	other	ADJ
ajlsi-2730	108	5	hand	hand	NOUN
ajlsi-2730	109	1	,	,	PUNCT
ajlsi-2730	109	2	secukinumab	secukinumab	NOUN
ajlsi-2730	109	3	is	be	AUX
ajlsi-2730	109	4	fda	fda	PROPN
ajlsi-2730	109	5	-	-	PUNCT
ajlsi-2730	109	6	approved	approve	VERB
ajlsi-2730	109	7	safe	safe	ADJ
ajlsi-2730	109	8	and	and	CCONJ
ajlsi-2730	109	9	effective	effective	ADJ
ajlsi-2730	109	10	therapy	therapy	NOUN
ajlsi-2730	109	11	even	even	ADV
ajlsi-2730	109	12	for	for	ADP
ajlsi-2730	109	13	severe	severe	ADJ
ajlsi-2730	109	14	erythrodermic	erythrodermic	ADJ
ajlsi-2730	109	15	ichthyosis	ichthyosis	NOUN
ajlsi-2730	109	16	.	.	PUNCT
ajlsi-2730	110	1	primary	primary	ADJ
ajlsi-2730	110	2	outcomes	outcome	NOUN
ajlsi-2730	110	3	of	of	ADP
ajlsi-2730	110	4	secukinumab	secukinumab	NOUN
ajlsi-2730	110	5	improvements	improvement	NOUN
ajlsi-2730	110	6	in	in	ADP
ajlsi-2730	110	7	skin	skin	NOUN
ajlsi-2730	110	8	texture	texture	NOUN
ajlsi-2730	110	9	and	and	CCONJ
ajlsi-2730	110	10	a	a	DET
ajlsi-2730	110	11	decrease	decrease	NOUN
ajlsi-2730	110	12	in	in	ADP
ajlsi-2730	110	13	the	the	DET
ajlsi-2730	110	14	production	production	NOUN
ajlsi-2730	110	15	of	of	ADP
ajlsi-2730	110	16	scales	scale	NOUN
ajlsi-2730	110	17	were	be	AUX
ajlsi-2730	110	18	observed	observe	VERB
ajlsi-2730	110	19	.	.	PUNCT
ajlsi-2730	111	1	furthermore	furthermore	ADV
ajlsi-2730	111	2	,	,	PUNCT
ajlsi-2730	111	3	there	there	PRON
ajlsi-2730	111	4	was	be	VERB
ajlsi-2730	111	5	a	a	DET
ajlsi-2730	111	6	noteworthy	noteworthy	ADJ
ajlsi-2730	111	7	decrease	decrease	NOUN
ajlsi-2730	111	8	in	in	ADP
ajlsi-2730	111	9	inflammation	inflammation	NOUN
ajlsi-2730	111	10	,	,	PUNCT
ajlsi-2730	111	11	as	as	SCONJ
ajlsi-2730	111	12	seen	see	VERB
ajlsi-2730	111	13	by	by	ADP
ajlsi-2730	111	14	a	a	DET
ajlsi-2730	111	15	45	45	NUM
ajlsi-2730	111	16	%	%	NOUN
ajlsi-2730	111	17	improvement	improvement	NOUN
ajlsi-2730	111	18	in	in	ADP
ajlsi-2730	111	19	the	the	DET
ajlsi-2730	111	20	ichthyosis	ichthyosis	NOUN
ajlsi-2730	111	21	area	area	NOUN
ajlsi-2730	111	22	severity	severity	NOUN
ajlsi-2730	111	23	index	index	NOUN
ajlsi-2730	111	24	score	score	NOUN
ajlsi-2730	111	25	within	within	ADP
ajlsi-2730	111	26	6	6	NUM
ajlsi-2730	111	27	months	month	NOUN
ajlsi-2730	111	28	of	of	ADP
ajlsi-2730	111	29	treatment	treatment	NOUN
ajlsi-2730	111	30	.	.	PUNCT
ajlsi-2730	112	1	secondary	secondary	ADJ
ajlsi-2730	112	2	outcomes	outcome	NOUN
ajlsi-2730	112	3	of	of	ADP
ajlsi-2730	112	4	secukinumab	secukinumab	NOUN
ajlsi-2730	112	5	secukinumab	secukinumab	NOUN
ajlsi-2730	112	6	is	be	AUX
ajlsi-2730	112	7	safe	safe	ADJ
ajlsi-2730	112	8	and	and	CCONJ
ajlsi-2730	112	9	effective	effective	ADJ
ajlsi-2730	112	10	in	in	ADP
ajlsi-2730	112	11	treating	treat	VERB
ajlsi-2730	112	12	children	child	NOUN
ajlsi-2730	112	13	with	with	ADP
ajlsi-2730	112	14	severe	severe	ADJ
ajlsi-2730	112	15	ichthyosis	ichthyosis	NOUN
ajlsi-2730	112	16	,	,	PUNCT
ajlsi-2730	112	17	significantly	significantly	ADV
ajlsi-2730	112	18	improving	improve	VERB
ajlsi-2730	112	19	the	the	DET
ajlsi-2730	112	20	severity	severity	NOUN
ajlsi-2730	112	21	of	of	ADP
ajlsi-2730	112	22	their	their	PRON
ajlsi-2730	112	23	symptoms	symptom	NOUN
ajlsi-2730	112	24	.	.	PUNCT
ajlsi-2730	113	1	remarkably	remarkably	ADV
ajlsi-2730	113	2	,	,	PUNCT
ajlsi-2730	113	3	the	the	DET
ajlsi-2730	113	4	cytokine	cytokine	NOUN
ajlsi-2730	113	5	profile	profile	NOUN
ajlsi-2730	113	6	returns	return	NOUN
ajlsi-2730	113	7	to	to	ADP
ajlsi-2730	113	8	normal	normal	ADJ
ajlsi-2730	113	9	after	after	ADP
ajlsi-2730	113	10	treatment	treatment	NOUN
ajlsi-2730	113	11	,	,	PUNCT
ajlsi-2730	113	12	and	and	CCONJ
ajlsi-2730	113	13	proinflammatory	proinflammatory	ADJ
ajlsi-2730	113	14	cytokines	cytokine	NOUN
ajlsi-2730	113	15	drop	drop	VERB
ajlsi-2730	113	16	.	.	PUNCT
ajlsi-2730	114	1	gastrointestinal	gastrointestinal	ADJ
ajlsi-2730	114	2	problems	problem	NOUN
ajlsi-2730	114	3	,	,	PUNCT
ajlsi-2730	114	4	hypersensitivity	hypersensitivity	NOUN
ajlsi-2730	114	5	reactions	reaction	NOUN
ajlsi-2730	114	6	,	,	PUNCT
ajlsi-2730	114	7	and	and	CCONJ
ajlsi-2730	114	8	musculoskeletal	musculoskeletal	ADJ
ajlsi-2730	114	9	pain	pain	NOUN
ajlsi-2730	114	10	have	have	AUX
ajlsi-2730	114	11	been	be	AUX
ajlsi-2730	114	12	linked	link	VERB
ajlsi-2730	114	13	to	to	ADP
ajlsi-2730	114	14	fewer	few	ADJ
ajlsi-2730	114	15	side	side	ADJ
ajlsi-2730	114	16	effects	effect	NOUN
ajlsi-2730	114	17	in	in	ADP
ajlsi-2730	114	18	conjunction	conjunction	NOUN
ajlsi-2730	114	19	with	with	ADP
ajlsi-2730	114	20	this	this	DET
ajlsi-2730	114	21	good	good	ADJ
ajlsi-2730	114	22	response	response	NOUN
ajlsi-2730	114	23	.	.	PUNCT
ajlsi-2730	115	1	these	these	DET
ajlsi-2730	115	2	results	result	NOUN
ajlsi-2730	115	3	demonstrate	demonstrate	VERB
ajlsi-2730	115	4	the	the	DET
ajlsi-2730	115	5	safety	safety	NOUN
ajlsi-2730	115	6	profile	profile	NOUN
ajlsi-2730	115	7	of	of	ADP
ajlsi-2730	115	8	secukinumab	secukinumab	NOUN
ajlsi-2730	115	9	and	and	CCONJ
ajlsi-2730	115	10	suggest	suggest	VERB
ajlsi-2730	115	11	it	it	PRON
ajlsi-2730	115	12	as	as	ADP
ajlsi-2730	115	13	a	a	DET
ajlsi-2730	115	14	viable	viable	ADJ
ajlsi-2730	115	15	therapy	therapy	NOUN
ajlsi-2730	115	16	for	for	ADP
ajlsi-2730	115	17	pediatric	pediatric	ADJ
ajlsi-2730	115	18	patients	patient	NOUN
ajlsi-2730	115	19	with	with	ADP
ajlsi-2730	115	20	severe	severe	ADJ
ajlsi-2730	115	21	ichthyosis	ichthyosis	NOUN
ajlsi-2730	115	22	.	.	PUNCT
ajlsi-2730	116	1	statistical	statistical	ADJ
ajlsi-2730	116	2	analysis	analysis	NOUN
ajlsi-2730	116	3	t	t	NOUN
ajlsi-2730	116	4	-	-	PUNCT
ajlsi-2730	116	5	tests	test	NOUN
ajlsi-2730	116	6	were	be	AUX
ajlsi-2730	116	7	used	use	VERB
ajlsi-2730	116	8	to	to	PART
ajlsi-2730	116	9	analyze	analyze	VERB
ajlsi-2730	116	10	associations	association	NOUN
ajlsi-2730	116	11	between	between	ADP
ajlsi-2730	116	12	secukinumab	secukinumab	NOUN
ajlsi-2730	116	13	’s	’s	PART
ajlsi-2730	116	14	effectiveness	effectiveness	NOUN
ajlsi-2730	116	15	and	and	CCONJ
ajlsi-2730	116	16	safety	safety	NOUN
ajlsi-2730	116	17	profile	profile	NOUN
ajlsi-2730	116	18	and	and	CCONJ
ajlsi-2730	116	19	that	that	PRON
ajlsi-2730	116	20	of	of	ADP
ajlsi-2730	116	21	ixekizumab	ixekizumab	NOUN
ajlsi-2730	116	22	and	and	CCONJ
ajlsi-2730	116	23	brodalumab	brodalumab	NOUN
ajlsi-2730	116	24	against	against	ADP
ajlsi-2730	116	25	placebo	placebo	NOUN
ajlsi-2730	116	26	.	.	PUNCT
ajlsi-2730	117	1	employing	employ	VERB
ajlsi-2730	117	2	an	an	DET
ajlsi-2730	117	3	area	area	NOUN
ajlsi-2730	117	4	severity	severity	NOUN
ajlsi-2730	117	5	index	index	NOUN
ajlsi-2730	117	6	score	score	NOUN
ajlsi-2730	117	7	assessment	assessment	NOUN
ajlsi-2730	117	8	of	of	ADP
ajlsi-2730	117	9	secukinumab	secukinumab	NOUN
ajlsi-2730	117	10	.	.	PUNCT
ajlsi-2730	118	1	at	at	ADP
ajlsi-2730	118	2	p	p	X
ajlsi-2730	118	3	<	<	X
ajlsi-2730	118	4	0.05	0.05	NUM
ajlsi-2730	118	5	,	,	PUNCT
ajlsi-2730	118	6	statistical	statistical	ADJ
ajlsi-2730	118	7	significance	significance	NOUN
ajlsi-2730	118	8	was	be	AUX
ajlsi-2730	118	9	determined	determine	VERB
ajlsi-2730	118	10	.	.	PUNCT
ajlsi-2730	119	1	results	result	NOUN
ajlsi-2730	119	2	and	and	CCONJ
ajlsi-2730	119	3	discussion	discussion	NOUN
ajlsi-2730	119	4	treatment	treatment	NOUN
ajlsi-2730	119	5	outcomes	outcome	NOUN
ajlsi-2730	119	6	efficacy	efficacy	PROPN
ajlsi-2730	119	7	of	of	ADP
ajlsi-2730	119	8	secukinumab	secukinumab	NOUN
ajlsi-2730	119	9	in	in	ADP
ajlsi-2730	119	10	comparison	comparison	NOUN
ajlsi-2730	119	11	with	with	ADP
ajlsi-2730	119	12	other	other	ADJ
ajlsi-2730	119	13	immune	immune	ADJ
ajlsi-2730	119	14	system	system	NOUN
ajlsi-2730	119	15	inhibitors	inhibitor	VERB
ajlsi-2730	119	16	the	the	DET
ajlsi-2730	119	17	efficacy	efficacy	NOUN
ajlsi-2730	119	18	of	of	ADP
ajlsi-2730	119	19	the	the	DET
ajlsi-2730	119	20	il-17	il-17	NOUN
ajlsi-2730	119	21	-	-	PUNCT
ajlsi-2730	119	22	a	a	DET
ajlsi-2730	119	23	inhibitor	inhibitor	NOUN
ajlsi-2730	119	24	,	,	PUNCT
ajlsi-2730	119	25	secukinumab	secukinumab	NOUN
ajlsi-2730	119	26	,	,	PUNCT
ajlsi-2730	119	27	was	be	AUX
ajlsi-2730	119	28	evaluated	evaluate	VERB
ajlsi-2730	119	29	by	by	ADP
ajlsi-2730	119	30	comparing	compare	VERB
ajlsi-2730	119	31	its	its	PRON
ajlsi-2730	119	32	treatment	treatment	NOUN
ajlsi-2730	119	33	outcomes	outcome	NOUN
ajlsi-2730	119	34	with	with	ADP
ajlsi-2730	119	35	tnf	tnf	PROPN
ajlsi-2730	119	36	-	-	PUNCT
ajlsi-2730	119	37	alpha	alpha	NOUN
ajlsi-2730	119	38	,	,	PUNCT
ajlsi-2730	119	39	il-4	il-4	X
ajlsi-2730	119	40	,	,	PUNCT
ajlsi-2730	119	41	and	and	CCONJ
ajlsi-2730	119	42	il-12/13	il-12/13	NOUN
ajlsi-2730	119	43	inhibitors	inhibitor	NOUN
ajlsi-2730	119	44	.	.	PUNCT
ajlsi-2730	120	1	given	give	VERB
ajlsi-2730	120	2	that	that	SCONJ
ajlsi-2730	120	3	il17	il17	PROPN
ajlsi-2730	120	4	-	-	PUNCT
ajlsi-2730	120	5	a	a	PRON
ajlsi-2730	120	6	is	be	AUX
ajlsi-2730	120	7	a	a	DET
ajlsi-2730	120	8	key	key	ADJ
ajlsi-2730	120	9	cytokine	cytokine	NOUN
ajlsi-2730	120	10	in	in	ADP
ajlsi-2730	120	11	various	various	ADJ
ajlsi-2730	120	12	forms	form	NOUN
ajlsi-2730	120	13	of	of	ADP
ajlsi-2730	120	14	ichthyosis	ichthyosis	NOUN
ajlsi-2730	120	15	,	,	PUNCT
ajlsi-2730	120	16	its	its	PRON
ajlsi-2730	120	17	targeted	target	VERB
ajlsi-2730	120	18	inhibition	inhibition	NOUN
ajlsi-2730	120	19	is	be	AUX
ajlsi-2730	120	20	deemed	deem	VERB
ajlsi-2730	120	21	essential	essential	ADJ
ajlsi-2730	120	22	compared	compare	VERB
ajlsi-2730	120	23	to	to	ADP
ajlsi-2730	120	24	other	other	ADJ
ajlsi-2730	120	25	cytokines	cytokine	NOUN
ajlsi-2730	120	26	.	.	PUNCT
ajlsi-2730	121	1	therefore	therefore	ADV
ajlsi-2730	121	2	,	,	PUNCT
ajlsi-2730	121	3	treatment	treatment	NOUN
ajlsi-2730	121	4	selection	selection	NOUN
ajlsi-2730	121	5	was	be	AUX
ajlsi-2730	121	6	based	base	VERB
ajlsi-2730	121	7	on	on	ADP
ajlsi-2730	121	8	disease	disease	NOUN
ajlsi-2730	121	9	-	-	PUNCT
ajlsi-2730	121	10	specific	specific	ADJ
ajlsi-2730	121	11	factors	factor	NOUN
ajlsi-2730	121	12	and	and	CCONJ
ajlsi-2730	121	13	symptom	symptom	NOUN
ajlsi-2730	121	14	severity	severity	NOUN
ajlsi-2730	121	15	,	,	PUNCT
ajlsi-2730	121	16	prioritizing	prioritize	VERB
ajlsi-2730	121	17	using	use	VERB
ajlsi-2730	121	18	secukinumab	secukinumab	NOUN
ajlsi-2730	121	19	as	as	ADP
ajlsi-2730	121	20	an	an	DET
ajlsi-2730	121	21	il-17	il-17	ADV
ajlsi-2730	121	22	-	-	PUNCT
ajlsi-2730	121	23	a	a	DET
ajlsi-2730	121	24	inhibitor	inhibitor	NOUN
ajlsi-2730	121	25	.	.	PUNCT
ajlsi-2730	122	1	secukinumab	secukinumab	NOUN
ajlsi-2730	122	2	demonstrated	demonstrate	VERB
ajlsi-2730	122	3	rapid	rapid	ADJ
ajlsi-2730	122	4	and	and	CCONJ
ajlsi-2730	122	5	effective	effective	ADJ
ajlsi-2730	122	6	symptom	symptom	NOUN
ajlsi-2730	122	7	reduction	reduction	NOUN
ajlsi-2730	122	8	,	,	PUNCT
ajlsi-2730	122	9	surpassing	surpass	VERB
ajlsi-2730	122	10	other	other	ADJ
ajlsi-2730	122	11	il-17	il-17	ADP
ajlsi-2730	122	12	inhibitors	inhibitor	NOUN
ajlsi-2730	122	13	like	like	ADP
ajlsi-2730	122	14	ixekizumab	ixekizumab	NOUN
ajlsi-2730	122	15	and	and	CCONJ
ajlsi-2730	122	16	brodalumab	brodalumab	NOUN
ajlsi-2730	122	17	.	.	PUNCT
ajlsi-2730	123	1	specifically	specifically	ADV
ajlsi-2730	123	2	,	,	PUNCT
ajlsi-2730	123	3	secukinumab	secukinumab	NOUN
ajlsi-2730	123	4	achieved	achieve	VERB
ajlsi-2730	123	5	a	a	DET
ajlsi-2730	123	6	45	45	NUM
ajlsi-2730	123	7	%	%	NOUN
ajlsi-2730	123	8	faster	fast	ADJ
ajlsi-2730	123	9	decrease	decrease	NOUN
ajlsi-2730	123	10	in	in	ADP
ajlsi-2730	123	11	area	area	NOUN
ajlsi-2730	123	12	severity	severity	NOUN
ajlsi-2730	123	13	index	index	NOUN
ajlsi-2730	123	14	score	score	NOUN
ajlsi-2730	123	15	and	and	CCONJ
ajlsi-2730	123	16	notable	notable	ADJ
ajlsi-2730	123	17	improvements	improvement	NOUN
ajlsi-2730	123	18	in	in	ADP
ajlsi-2730	123	19	skin	skin	NOUN
ajlsi-2730	123	20	scaling	scaling	NOUN
ajlsi-2730	123	21	and	and	CCONJ
ajlsi-2730	123	22	texture	texture	NOUN
ajlsi-2730	123	23	against	against	ADP
ajlsi-2730	123	24	the	the	DET
ajlsi-2730	123	25	placebo	placebo	NOUN
ajlsi-2730	123	26	-	-	PUNCT
ajlsi-2730	123	27	treated	treat	VERB
ajlsi-2730	123	28	control	control	NOUN
ajlsi-2730	123	29	group	group	NOUN
ajlsi-2730	123	30	.	.	PUNCT
ajlsi-2730	124	1	these	these	DET
ajlsi-2730	124	2	results	result	NOUN
ajlsi-2730	124	3	underscore	underscore	VERB
ajlsi-2730	124	4	the	the	DET
ajlsi-2730	124	5	efficiency	efficiency	NOUN
ajlsi-2730	124	6	of	of	ADP
ajlsi-2730	124	7	secukinumab	secukinumab	NOUN
ajlsi-2730	124	8	as	as	ADP
ajlsi-2730	124	9	a	a	DET
ajlsi-2730	124	10	treatment	treatment	NOUN
ajlsi-2730	124	11	for	for	ADP
ajlsi-2730	124	12	ichthyosis	ichthyosis	NOUN
ajlsi-2730	124	13	,	,	PUNCT
ajlsi-2730	124	14	particularly	particularly	ADV
ajlsi-2730	124	15	in	in	ADP
ajlsi-2730	124	16	addressing	address	VERB
ajlsi-2730	124	17	symptom	symptom	NOUN
ajlsi-2730	124	18	severity	severity	NOUN
ajlsi-2730	124	19	and	and	CCONJ
ajlsi-2730	124	20	enhancing	enhance	VERB
ajlsi-2730	124	21	skin	skin	NOUN
ajlsi-2730	124	22	quality	quality	NOUN
ajlsi-2730	124	23	.	.	PUNCT
ajlsi-2730	125	1	safety	safety	NOUN
ajlsi-2730	125	2	profile	profile	NOUN
ajlsi-2730	125	3	and	and	CCONJ
ajlsi-2730	125	4	adverse	adverse	ADJ
ajlsi-2730	125	5	events	event	NOUN
ajlsi-2730	125	6	in	in	ADP
ajlsi-2730	125	7	comparison	comparison	NOUN
ajlsi-2730	125	8	with	with	ADP
ajlsi-2730	125	9	other	other	ADJ
ajlsi-2730	125	10	il-17	il-17	NOUN
ajlsi-2730	125	11	-	-	PUNCT
ajlsi-2730	125	12	a	a	DET
ajlsi-2730	125	13	inhibitors	inhibitor	NOUN
ajlsi-2730	125	14	secukinumab	secukinumab	NOUN
ajlsi-2730	125	15	demonstrated	demonstrate	VERB
ajlsi-2730	125	16	high	high	ADJ
ajlsi-2730	125	17	effectiveness	effectiveness	NOUN
ajlsi-2730	125	18	and	and	CCONJ
ajlsi-2730	125	19	a	a	DET
ajlsi-2730	125	20	lower	low	ADJ
ajlsi-2730	125	21	incidence	incidence	NOUN
ajlsi-2730	125	22	of	of	ADP
ajlsi-2730	125	23	hypersensitivity	hypersensitivity	NOUN
ajlsi-2730	125	24	reactions	reaction	NOUN
ajlsi-2730	125	25	and	and	CCONJ
ajlsi-2730	125	26	gastrointestinal	gastrointestinal	ADJ
ajlsi-2730	125	27	issues	issue	NOUN
ajlsi-2730	125	28	than	than	ADP
ajlsi-2730	125	29	ixekizumab	ixekizumab	NOUN
ajlsi-2730	125	30	and	and	CCONJ
ajlsi-2730	125	31	brodalumab	brodalumab	NOUN
ajlsi-2730	125	32	.	.	PUNCT
ajlsi-2730	126	1	however	however	ADV
ajlsi-2730	126	2	,	,	PUNCT
ajlsi-2730	126	3	it	it	PRON
ajlsi-2730	126	4	is	be	AUX
ajlsi-2730	126	5	important	important	ADJ
ajlsi-2730	126	6	to	to	PART
ajlsi-2730	126	7	note	note	VERB
ajlsi-2730	126	8	that	that	SCONJ
ajlsi-2730	126	9	brodalumab	brodalumab	NOUN
ajlsi-2730	126	10	carries	carry	VERB
ajlsi-2730	126	11	a	a	DET
ajlsi-2730	126	12	risk	risk	NOUN
ajlsi-2730	126	13	of	of	ADP
ajlsi-2730	126	14	affecting	affect	VERB
ajlsi-2730	126	15	mental	mental	ADJ
ajlsi-2730	126	16	health	health	NOUN
ajlsi-2730	126	17	by	by	ADP
ajlsi-2730	126	18	potentially	potentially	ADV
ajlsi-2730	126	19	causing	cause	VERB
ajlsi-2730	126	20	depression	depression	NOUN
ajlsi-2730	126	21	and	and	CCONJ
ajlsi-2730	126	22	generating	generating	ADJ
ajlsi-2730	126	23	suicidal	suicidal	ADJ
ajlsi-2730	126	24	ideation	ideation	NOUN
ajlsi-2730	126	25	.	.	PUNCT
ajlsi-2730	127	1	additionally	additionally	ADV
ajlsi-2730	127	2	,	,	PUNCT
ajlsi-2730	127	3	there	there	PRON
ajlsi-2730	127	4	is	be	VERB
ajlsi-2730	127	5	a	a	DET
ajlsi-2730	127	6	risk	risk	NOUN
ajlsi-2730	127	7	of	of	ADP
ajlsi-2730	127	8	malignancies	malignancy	NOUN
ajlsi-2730	127	9	in	in	ADP
ajlsi-2730	127	10	patients	patient	NOUN
ajlsi-2730	127	11	using	use	VERB
ajlsi-2730	127	12	ixekizumab	ixekizumab	NOUN
ajlsi-2730	127	13	and	and	CCONJ
ajlsi-2730	127	14	brodalumab	brodalumab	NOUN
ajlsi-2730	127	15	for	for	ADP
ajlsi-2730	127	16	the	the	DET
ajlsi-2730	127	17	treatment	treatment	NOUN
ajlsi-2730	127	18	of	of	ADP
ajlsi-2730	127	19	ichthyosis	ichthyosis	NOUN
ajlsi-2730	127	20	.	.	PUNCT
ajlsi-2730	128	1	discussion	discussion	NOUN
ajlsi-2730	128	2	childhood	childhood	NOUN
ajlsi-2730	128	3	ichthyosis	ichthyosis	NOUN
ajlsi-2730	128	4	is	be	AUX
ajlsi-2730	128	5	a	a	DET
ajlsi-2730	128	6	rare	rare	ADJ
ajlsi-2730	128	7	skin	skin	NOUN
ajlsi-2730	128	8	condition	condition	NOUN
ajlsi-2730	128	9	characterized	characterize	VERB
ajlsi-2730	128	10	by	by	ADP
ajlsi-2730	128	11	extremely	extremely	ADV
ajlsi-2730	128	12	dry	dry	ADJ
ajlsi-2730	128	13	surface	surface	NOUN
ajlsi-2730	128	14	scales	scale	NOUN
ajlsi-2730	128	15	.	.	PUNCT
ajlsi-2730	129	1	it	it	PRON
ajlsi-2730	129	2	is	be	AUX
ajlsi-2730	129	3	also	also	ADV
ajlsi-2730	129	4	known	know	VERB
ajlsi-2730	129	5	by	by	ADP
ajlsi-2730	129	6	the	the	DET
ajlsi-2730	129	7	names	name	NOUN
ajlsi-2730	129	8	lamellar	lamellar	ADJ
ajlsi-2730	129	9	ichthyosis	ichthyosis	NOUN
ajlsi-2730	129	10	,	,	PUNCT
ajlsi-2730	129	11	x	x	X
ajlsi-2730	129	12	-	-	VERB
ajlsi-2730	129	13	linked	link	VERB
ajlsi-2730	129	14	recessive	recessive	ADJ
ajlsi-2730	129	15	ichthyosis	ichthyosis	NOUN
ajlsi-2730	129	16	,	,	PUNCT
ajlsi-2730	129	17	and	and	CCONJ
ajlsi-2730	129	18	ichthyosis	ichthyosis	NOUN
ajlsi-2730	129	19	vulgaris	vulgaris	NOUN
ajlsi-2730	129	20	.	.	PUNCT
ajlsi-2730	130	1	a	a	DET
ajlsi-2730	130	2	prenatal	prenatal	ADJ
ajlsi-2730	130	3	mutation	mutation	NOUN
ajlsi-2730	130	4	or	or	CCONJ
ajlsi-2730	130	5	hereditary	hereditary	ADJ
ajlsi-2730	130	6	genes	gene	NOUN
ajlsi-2730	130	7	may	may	AUX
ajlsi-2730	130	8	impact	impact	VERB
ajlsi-2730	130	9	the	the	DET
ajlsi-2730	130	10	filaggrin	filaggrin	ADJ
ajlsi-2730	130	11	protein	protein	NOUN
ajlsi-2730	130	12	in	in	ADP
ajlsi-2730	130	13	the	the	DET
ajlsi-2730	130	14	skin	skin	NOUN
ajlsi-2730	130	15	.	.	PUNCT
ajlsi-2730	131	1	acquired	acquire	VERB
ajlsi-2730	131	2	ichthyosis	ichthyosis	NOUN
ajlsi-2730	131	3	vulgaris	vulgaris	NOUN
ajlsi-2730	131	4	in	in	ADP
ajlsi-2730	131	5	adults	adult	NOUN
ajlsi-2730	131	6	can	can	AUX
ajlsi-2730	131	7	result	result	VERB
ajlsi-2730	131	8	from	from	ADP
ajlsi-2730	131	9	several	several	ADJ
ajlsi-2730	131	10	different	different	ADJ
ajlsi-2730	131	11	illnesses	illness	NOUN
ajlsi-2730	131	12	.	.	PUNCT
ajlsi-2730	132	1	research	research	NOUN
ajlsi-2730	132	2	on	on	ADP
ajlsi-2730	132	3	children	child	NOUN
ajlsi-2730	132	4	with	with	ADP
ajlsi-2730	132	5	ichthyosis	ichthyosis	NOUN
ajlsi-2730	132	6	reveals	reveal	VERB
ajlsi-2730	132	7	a	a	DET
ajlsi-2730	132	8	th17dominant	th17dominant	PROPN
ajlsi-2730	132	9	immune	immune	ADJ
ajlsi-2730	132	10	profile	profile	NOUN
ajlsi-2730	132	11	with	with	ADP
ajlsi-2730	132	12	elevated	elevated	ADJ
ajlsi-2730	132	13	expression	expression	NOUN
ajlsi-2730	132	14	of	of	ADP
ajlsi-2730	132	15	il17	il17	PROPN
ajlsi-2730	132	16	/	/	SYM
ajlsi-2730	132	17	tnfα	tnfα	NOUN
ajlsi-2730	132	18	-	-	PUNCT
ajlsi-2730	132	19	synergistic	synergistic	ADJ
ajlsi-2730	132	20	/	/	SYM
ajlsi-2730	132	21	additive	additive	ADJ
ajlsi-2730	132	22	genes	gene	NOUN
ajlsi-2730	132	23	,	,	PUNCT
ajlsi-2730	132	24	similar	similar	ADJ
ajlsi-2730	132	25	to	to	ADP
ajlsi-2730	132	26	psoriasis	psoriasis	NOUN
ajlsi-2730	132	27	.	.	PUNCT
ajlsi-2730	133	1	immune	immune	ADJ
ajlsi-2730	133	2	system	system	NOUN
ajlsi-2730	133	3	inhibitors	inhibitor	NOUN
ajlsi-2730	133	4	targeting	target	VERB
ajlsi-2730	133	5	tnf	tnf	PROPN
ajlsi-2730	133	6	-	-	PUNCT
ajlsi-2730	133	7	alpha	alpha	NOUN
ajlsi-2730	133	8	,	,	PUNCT
ajlsi-2730	133	9	il17a	il17a	PROPN
ajlsi-2730	133	10	,	,	PUNCT
ajlsi-2730	133	11	il-4	il-4	X
ajlsi-2730	133	12	,	,	PUNCT
ajlsi-2730	133	13	and	and	CCONJ
ajlsi-2730	133	14	il-12	il-12	NOUN
ajlsi-2730	133	15	have	have	AUX
ajlsi-2730	133	16	shown	show	VERB
ajlsi-2730	133	17	potential	potential	NOUN
ajlsi-2730	133	18	in	in	ADP
ajlsi-2730	133	19	treating	treat	VERB
ajlsi-2730	133	20	immunological	immunological	ADJ
ajlsi-2730	133	21	dysregulation	dysregulation	NOUN
ajlsi-2730	133	22	and	and	CCONJ
ajlsi-2730	133	23	inflammation	inflammation	NOUN
ajlsi-2730	133	24	.	.	PUNCT
ajlsi-2730	134	1	these	these	DET
ajlsi-2730	134	2	drugs	drug	NOUN
ajlsi-2730	134	3	,	,	PUNCT
ajlsi-2730	134	4	including	include	VERB
ajlsi-2730	134	5	etanercept	etanercept	NOUN
ajlsi-2730	134	6	,	,	PUNCT
ajlsi-2730	134	7	adalimumab	adalimumab	NOUN
ajlsi-2730	134	8	,	,	PUNCT
ajlsi-2730	134	9	infliximab	infliximab	NOUN
ajlsi-2730	134	10	,	,	PUNCT
ajlsi-2730	134	11	secukinumab	secukinumab	NOUN
ajlsi-2730	134	12	,	,	PUNCT
ajlsi-2730	134	13	ixekizumab	ixekizumab	NOUN
ajlsi-2730	134	14	,	,	PUNCT
ajlsi-2730	134	15	brodalumab	brodalumab	NOUN
ajlsi-2730	134	16	,	,	PUNCT
ajlsi-2730	134	17	dupilumab	dupilumab	NOUN
ajlsi-2730	134	18	,	,	PUNCT
ajlsi-2730	134	19	and	and	CCONJ
ajlsi-2730	134	20	ustekinumab	ustekinumab	NOUN
ajlsi-2730	134	21	,	,	PUNCT
ajlsi-2730	134	22	may	may	AUX
ajlsi-2730	134	23	improve	improve	VERB
ajlsi-2730	134	24	quality	quality	NOUN
ajlsi-2730	134	25	of	of	ADP
ajlsi-2730	134	26	life	life	NOUN
ajlsi-2730	134	27	in	in	ADP
ajlsi-2730	134	28	pediatric	pediatric	ADJ
ajlsi-2730	134	29	ichthyosis	ichthyosis	NOUN
ajlsi-2730	134	30	treatment	treatment	NOUN
ajlsi-2730	134	31	.	.	PUNCT
ajlsi-2730	135	1	long	long	ADJ
ajlsi-2730	135	2	-	-	PUNCT
ajlsi-2730	135	3	term	term	NOUN
ajlsi-2730	135	4	retinoid	retinoid	NOUN
ajlsi-2730	135	5	therapy	therapy	NOUN
ajlsi-2730	135	6	is	be	AUX
ajlsi-2730	135	7	necessary	necessary	ADJ
ajlsi-2730	135	8	for	for	ADP
ajlsi-2730	135	9	ichthyoses	ichthyose	NOUN
ajlsi-2730	135	10	and	and	CCONJ
ajlsi-2730	135	11	cornification	cornification	NOUN
ajlsi-2730	135	12	problems	problem	NOUN
ajlsi-2730	135	13	,	,	PUNCT
ajlsi-2730	135	14	although	although	SCONJ
ajlsi-2730	135	15	it	it	PRON
ajlsi-2730	135	16	can	can	AUX
ajlsi-2730	135	17	have	have	VERB
ajlsi-2730	135	18	detrimental	detrimental	ADJ
ajlsi-2730	135	19	consequences	consequence	NOUN
ajlsi-2730	135	20	on	on	ADP
ajlsi-2730	135	21	the	the	DET
ajlsi-2730	135	22	eyes	eye	NOUN
ajlsi-2730	135	23	,	,	PUNCT
ajlsi-2730	135	24	bones	bone	NOUN
ajlsi-2730	135	25	,	,	PUNCT
ajlsi-2730	135	26	heart	heart	NOUN
ajlsi-2730	135	27	,	,	PUNCT
ajlsi-2730	135	28	and	and	CCONJ
ajlsi-2730	135	29	brain	brain	NOUN
ajlsi-2730	135	30	.	.	PUNCT
ajlsi-2730	136	1	netherton	netherton	PROPN
ajlsi-2730	136	2	syndrome	syndrome	NOUN
ajlsi-2730	136	3	and	and	CCONJ
ajlsi-2730	136	4	autosomal	autosomal	ADJ
ajlsi-2730	136	5	recessive	recessive	ADJ
ajlsi-2730	136	6	congenital	congenital	ADJ
ajlsi-2730	136	7	ichthyosis	ichthyosis	NOUN
ajlsi-2730	136	8	treatments	treatment	NOUN
ajlsi-2730	136	9	include	include	VERB
ajlsi-2730	136	10	gene	gene	NOUN
ajlsi-2730	136	11	therapy	therapy	NOUN
ajlsi-2730	136	12	and	and	CCONJ
ajlsi-2730	136	13	protein	protein	NOUN
ajlsi-2730	136	14	substitution	substitution	NOUN
ajlsi-2730	136	15	.	.	PUNCT
ajlsi-2730	137	1	the	the	DET
ajlsi-2730	137	2	present	present	ADJ
ajlsi-2730	137	3	research	research	NOUN
ajlsi-2730	137	4	study	study	NOUN
ajlsi-2730	137	5	involved	involve	VERB
ajlsi-2730	137	6	30	30	NUM
ajlsi-2730	137	7	pediatric	pediatric	ADJ
ajlsi-2730	137	8	patients	patient	NOUN
ajlsi-2730	137	9	diagnosed	diagnose	VERB
ajlsi-2730	137	10	with	with	ADP
ajlsi-2730	137	11	ichthyosis	ichthyosis	NOUN
ajlsi-2730	137	12	skin	skin	NOUN
ajlsi-2730	137	13	diseases	disease	NOUN
ajlsi-2730	137	14	in	in	ADP
ajlsi-2730	137	15	uae	uae	PROPN
ajlsi-2730	137	16	from	from	ADP
ajlsi-2730	137	17	november	november	PROPN
ajlsi-2730	137	18	to	to	ADP
ajlsi-2730	137	19	february	february	PROPN
ajlsi-2730	137	20	2024	2024	NUM
ajlsi-2730	137	21	.	.	PUNCT
ajlsi-2730	138	1	participants	participant	NOUN
ajlsi-2730	138	2	included	include	VERB
ajlsi-2730	138	3	those	those	PRON
ajlsi-2730	138	4	aged	aged	ADJ
ajlsi-2730	138	5	6	6	NUM
ajlsi-2730	138	6	-	-	SYM
ajlsi-2730	138	7	12	12	NUM
ajlsi-2730	138	8	with	with	ADP
ajlsi-2730	138	9	recent	recent	ADJ
ajlsi-2730	138	10	or	or	CCONJ
ajlsi-2730	138	11	previous	previous	ADJ
ajlsi-2730	138	12	diagnoses	diagnosis	NOUN
ajlsi-2730	138	13	.	.	PUNCT
ajlsi-2730	139	1	key	key	ADJ
ajlsi-2730	139	2	ichthyosis	ichthyosis	NOUN
ajlsi-2730	139	3	conditions	condition	NOUN
ajlsi-2730	139	4	were	be	AUX
ajlsi-2730	139	5	included	include	VERB
ajlsi-2730	139	6	.	.	PUNCT
ajlsi-2730	140	1	the	the	DET
ajlsi-2730	140	2	study	study	NOUN
ajlsi-2730	140	3	found	find	VERB
ajlsi-2730	140	4	that	that	SCONJ
ajlsi-2730	140	5	tnf	tnf	PROPN
ajlsi-2730	140	6	-	-	PUNCT
ajlsi-2730	140	7	alpha	alpha	NOUN
ajlsi-2730	140	8	and	and	CCONJ
ajlsi-2730	140	9	il-17	il-17	PART
ajlsi-2730	140	10	activate	activate	VERB
ajlsi-2730	140	11	genes	gene	NOUN
ajlsi-2730	140	12	and	and	CCONJ
ajlsi-2730	140	13	markers	marker	NOUN
ajlsi-2730	140	14	related	relate	VERB
ajlsi-2730	140	15	to	to	ADP
ajlsi-2730	140	16	il-17	il-17	NUM
ajlsi-2730	140	17	,	,	PUNCT
ajlsi-2730	140	18	leading	lead	VERB
ajlsi-2730	140	19	to	to	ADP
ajlsi-2730	140	20	increased	increase	VERB
ajlsi-2730	140	21	th17a	th17a	NOUN
ajlsi-2730	140	22	cytokine	cytokine	NOUN
ajlsi-2730	140	23	levels	level	NOUN
ajlsi-2730	140	24	.	.	PUNCT
ajlsi-2730	141	1	idh	idh	NOUN
ajlsi-2730	141	2	-	-	PUNCT
ajlsi-2730	141	3	related	relate	VERB
ajlsi-2730	141	4	th2	th2	PROPN
ajlsi-2730	141	5	cytokine	cytokine	NOUN
ajlsi-2730	141	6	il-4	il-4	PART
ajlsi-2730	141	7	expression	expression	NOUN
ajlsi-2730	141	8	levels	level	NOUN
ajlsi-2730	141	9	were	be	AUX
ajlsi-2730	141	10	comparable	comparable	ADJ
ajlsi-2730	141	11	to	to	ADP
ajlsi-2730	141	12	controls	control	NOUN
ajlsi-2730	141	13	.	.	PUNCT
ajlsi-2730	142	1	il-12	il-12	NOUN
ajlsi-2730	142	2	also	also	ADV
ajlsi-2730	142	3	impacts	impact	VERB
ajlsi-2730	142	4	th1	th1	PROPN
ajlsi-2730	142	5	immune	immune	ADJ
ajlsi-2730	142	6	responses	response	NOUN
ajlsi-2730	142	7	.	.	PUNCT
ajlsi-2730	143	1	this	this	DET
ajlsi-2730	143	2	research	research	NOUN
ajlsi-2730	143	3	study	study	NOUN
ajlsi-2730	143	4	focused	focus	VERB
ajlsi-2730	143	5	on	on	ADP
ajlsi-2730	143	6	key	key	ADJ
ajlsi-2730	143	7	cytokine	cytokine	NOUN
ajlsi-2730	143	8	il-17	il-17	NOUN
ajlsi-2730	143	9	-	-	PUNCT
ajlsi-2730	143	10	a	a	PRON
ajlsi-2730	143	11	to	to	PART
ajlsi-2730	143	12	reduce	reduce	VERB
ajlsi-2730	143	13	inflammatory	inflammatory	ADJ
ajlsi-2730	143	14	and	and	CCONJ
ajlsi-2730	143	15	allergic	allergic	ADJ
ajlsi-2730	143	16	symptoms	symptom	NOUN
ajlsi-2730	143	17	in	in	ADP
ajlsi-2730	143	18	pediatric	pediatric	ADJ
ajlsi-2730	143	19	ichthyosis	ichthyosis	NOUN
ajlsi-2730	143	20	patients	patient	NOUN
ajlsi-2730	143	21	aged	age	VERB
ajlsi-2730	143	22	6	6	NUM
ajlsi-2730	143	23	-	-	SYM
ajlsi-2730	143	24	12	12	NUM
ajlsi-2730	143	25	.	.	PUNCT
ajlsi-2730	144	1	il-17a	il-17a	PROPN
ajlsi-2730	144	2	inhibitors	inhibitor	NOUN
ajlsi-2730	144	3	secukinumab	secukinumab	VERB
ajlsi-2730	144	4	,	,	PUNCT
ajlsi-2730	144	5	ixekizumab	ixekizumab	NOUN
ajlsi-2730	144	6	,	,	PUNCT
ajlsi-2730	144	7	and	and	CCONJ
ajlsi-2730	144	8	brodalumab	brodalumab	NOUN
ajlsi-2730	144	9	were	be	AUX
ajlsi-2730	144	10	administered	administer	VERB
ajlsi-2730	144	11	to	to	ADP
ajlsi-2730	144	12	patients	patient	NOUN
ajlsi-2730	144	13	with	with	ADP
ajlsi-2730	144	14	various	various	ADJ
ajlsi-2730	144	15	ichthyosis	ichthyosis	NOUN
ajlsi-2730	144	16	types	type	NOUN
ajlsi-2730	144	17	.	.	PUNCT
ajlsi-2730	145	1	after	after	ADP
ajlsi-2730	145	2	5	5	NUM
ajlsi-2730	145	3	months	month	NOUN
ajlsi-2730	145	4	,	,	PUNCT
ajlsi-2730	145	5	patients	patient	NOUN
ajlsi-2730	145	6	with	with	ADP
ajlsi-2730	145	7	secukinumab	secukinumab	NOUN
ajlsi-2730	145	8	showed	show	VERB
ajlsi-2730	145	9	positive	positive	ADJ
ajlsi-2730	145	10	results	result	NOUN
ajlsi-2730	145	11	,	,	PUNCT
ajlsi-2730	145	12	decreased	decrease	VERB
ajlsi-2730	145	13	ichthyosis	ichthyosis	NOUN
ajlsi-2730	145	14	severity	severity	NOUN
ajlsi-2730	145	15	index	index	NOUN
ajlsi-2730	145	16	scores	score	NOUN
ajlsi-2730	145	17	by	by	ADP
ajlsi-2730	145	18	45	45	NUM
ajlsi-2730	145	19	-	-	SYM
ajlsi-2730	145	20	50	50	NUM
ajlsi-2730	145	21	%	%	NOUN
ajlsi-2730	145	22	,	,	PUNCT
ajlsi-2730	145	23	and	and	CCONJ
ajlsi-2730	145	24	significantly	significantly	ADV
ajlsi-2730	145	25	reduced	reduce	VERB
ajlsi-2730	145	26	cytokine	cytokine	ADJ
ajlsi-2730	145	27	proinflammatory	proinflammatory	ADJ
ajlsi-2730	145	28	rate	rate	NOUN
ajlsi-2730	145	29	.	.	PUNCT
ajlsi-2730	146	1	compared	compare	VERB
ajlsi-2730	146	2	to	to	ADP
ajlsi-2730	146	3	il-17	il-17	NUM
ajlsi-2730	146	4	inhibitors	inhibitor	NOUN
ajlsi-2730	146	5	such	such	ADJ
ajlsi-2730	146	6	as	as	ADP
ajlsi-2730	146	7	ixekizumab	ixekizumab	NOUN
ajlsi-2730	146	8	and	and	CCONJ
ajlsi-2730	146	9	brodalumab	brodalumab	NOUN
ajlsi-2730	146	10	,	,	PUNCT
ajlsi-2730	146	11	secukinumab	secukinumab	NOUN
ajlsi-2730	146	12	showed	show	VERB
ajlsi-2730	146	13	faster	fast	ADV
ajlsi-2730	146	14	and	and	CCONJ
ajlsi-2730	146	15	more	more	ADV
ajlsi-2730	146	16	significant	significant	ADJ
ajlsi-2730	146	17	symptom	symptom	NOUN
ajlsi-2730	146	18	reduction	reduction	NOUN
ajlsi-2730	146	19	.	.	PUNCT
ajlsi-2730	147	1	secukinumab	secukinumab	NOUN
ajlsi-2730	147	2	specifically	specifically	ADV
ajlsi-2730	147	3	produced	produce	VERB
ajlsi-2730	147	4	a	a	DET
ajlsi-2730	147	5	45	45	NUM
ajlsi-2730	147	6	%	%	NOUN
ajlsi-2730	147	7	quicker	quick	ADJ
ajlsi-2730	147	8	reduction	reduction	NOUN
ajlsi-2730	147	9	in	in	ADP
ajlsi-2730	147	10	the	the	DET
ajlsi-2730	147	11	area	area	NOUN
ajlsi-2730	147	12	severity	severity	NOUN
ajlsi-2730	147	13	pa	pa	PROPN
ajlsi-2730	147	14	ge	ge	PROPN
ajlsi-2730	147	15	73	73	NUM
ajlsi-2730	147	16	https://journals.e-palli.com/home/index.php/ajlsi	https://journals.e-palli.com/home/index.php/ajlsi	PROPN
ajlsi-2730	147	17	am	am	NOUN
ajlsi-2730	147	18	.	.	PUNCT
ajlsi-2730	148	1	j.	j.	PROPN
ajlsi-2730	148	2	life	life	PROPN
ajlsi-2730	148	3	sci	sci	PROPN
ajlsi-2730	148	4	.	.	PUNCT
ajlsi-2730	148	5	innov	innov	PROPN
ajlsi-2730	148	6	.	.	PUNCT
ajlsi-2730	149	1	3(1	3(1	NUM
ajlsi-2730	149	2	)	)	PUNCT
ajlsi-2730	149	3	69	69	NUM
ajlsi-2730	149	4	-	-	SYM
ajlsi-2730	149	5	74	74	NUM
ajlsi-2730	149	6	,	,	PUNCT
ajlsi-2730	149	7	2024	2024	NUM
ajlsi-2730	149	8	index	index	NOUN
ajlsi-2730	149	9	score	score	NOUN
ajlsi-2730	149	10	and	and	CCONJ
ajlsi-2730	149	11	appreciable	appreciable	ADJ
ajlsi-2730	149	12	changes	change	NOUN
ajlsi-2730	149	13	in	in	ADP
ajlsi-2730	149	14	the	the	DET
ajlsi-2730	149	15	scale	scale	NOUN
ajlsi-2730	149	16	and	and	CCONJ
ajlsi-2730	149	17	texture	texture	NOUN
ajlsi-2730	149	18	of	of	ADP
ajlsi-2730	149	19	the	the	DET
ajlsi-2730	149	20	skin	skin	NOUN
ajlsi-2730	149	21	.	.	PUNCT
ajlsi-2730	150	1	these	these	DET
ajlsi-2730	150	2	outcomes	outcome	NOUN
ajlsi-2730	150	3	highlight	highlight	VERB
ajlsi-2730	150	4	how	how	SCONJ
ajlsi-2730	150	5	well	well	ADV
ajlsi-2730	150	6	secukinumab	secukinumab	NOUN
ajlsi-2730	150	7	treats	treat	VERB
ajlsi-2730	150	8	ichthyosis	ichthyosis	NOUN
ajlsi-2730	150	9	,	,	PUNCT
ajlsi-2730	150	10	especially	especially	ADV
ajlsi-2730	150	11	when	when	SCONJ
ajlsi-2730	150	12	improving	improve	VERB
ajlsi-2730	150	13	skin	skin	NOUN
ajlsi-2730	150	14	quality	quality	NOUN
ajlsi-2730	150	15	and	and	CCONJ
ajlsi-2730	150	16	symptom	symptom	NOUN
ajlsi-2730	150	17	severity	severity	NOUN
ajlsi-2730	150	18	.	.	PUNCT
ajlsi-2730	151	1	compared	compare	VERB
ajlsi-2730	151	2	to	to	ADP
ajlsi-2730	151	3	ixekizumab	ixekizumab	NOUN
ajlsi-2730	151	4	and	and	CCONJ
ajlsi-2730	151	5	brodalumab	brodalumab	NOUN
ajlsi-2730	151	6	,	,	PUNCT
ajlsi-2730	151	7	secukinumab	secukinumab	NOUN
ajlsi-2730	151	8	showed	show	VERB
ajlsi-2730	151	9	great	great	ADJ
ajlsi-2730	151	10	efficacy	efficacy	NOUN
ajlsi-2730	151	11	and	and	CCONJ
ajlsi-2730	151	12	a	a	DET
ajlsi-2730	151	13	decreased	decrease	VERB
ajlsi-2730	151	14	rate	rate	NOUN
ajlsi-2730	151	15	of	of	ADP
ajlsi-2730	151	16	hypersensitivity	hypersensitivity	NOUN
ajlsi-2730	151	17	responses	response	NOUN
ajlsi-2730	151	18	and	and	CCONJ
ajlsi-2730	151	19	gastrointestinal	gastrointestinal	ADJ
ajlsi-2730	151	20	problems	problem	NOUN
ajlsi-2730	151	21	against	against	ADP
ajlsi-2730	151	22	a	a	DET
ajlsi-2730	151	23	control	control	NOUN
ajlsi-2730	151	24	group	group	NOUN
ajlsi-2730	151	25	.	.	PUNCT
ajlsi-2730	152	1	however	however	ADV
ajlsi-2730	152	2	,	,	PUNCT
ajlsi-2730	152	3	it	it	PRON
ajlsi-2730	152	4	is	be	AUX
ajlsi-2730	152	5	crucial	crucial	ADJ
ajlsi-2730	152	6	to	to	PART
ajlsi-2730	152	7	remember	remember	VERB
ajlsi-2730	152	8	that	that	SCONJ
ajlsi-2730	152	9	brodalumab	brodalumab	NOUN
ajlsi-2730	152	10	poses	pose	VERB
ajlsi-2730	152	11	a	a	DET
ajlsi-2730	152	12	risk	risk	NOUN
ajlsi-2730	152	13	of	of	ADP
ajlsi-2730	152	14	harming	harm	VERB
ajlsi-2730	152	15	mental	mental	ADJ
ajlsi-2730	152	16	health	health	NOUN
ajlsi-2730	152	17	,	,	PUNCT
ajlsi-2730	152	18	as	as	SCONJ
ajlsi-2730	152	19	it	it	PRON
ajlsi-2730	152	20	may	may	AUX
ajlsi-2730	152	21	lead	lead	VERB
ajlsi-2730	152	22	to	to	ADP
ajlsi-2730	152	23	suicidal	suicidal	ADJ
ajlsi-2730	152	24	thoughts	thought	NOUN
ajlsi-2730	152	25	and	and	CCONJ
ajlsi-2730	152	26	sadness	sadness	NOUN
ajlsi-2730	152	27	.	.	PUNCT
ajlsi-2730	153	1	furthermore	furthermore	ADV
ajlsi-2730	153	2	,	,	PUNCT
ajlsi-2730	153	3	those	those	PRON
ajlsi-2730	153	4	treated	treat	VERB
ajlsi-2730	153	5	for	for	ADP
ajlsi-2730	153	6	ichthyosis	ichthyosis	NOUN
ajlsi-2730	153	7	with	with	ADP
ajlsi-2730	153	8	ixekizumab	ixekizumab	NOUN
ajlsi-2730	153	9	and	and	CCONJ
ajlsi-2730	153	10	brodalumab	brodalumab	NOUN
ajlsi-2730	153	11	run	run	VERB
ajlsi-2730	153	12	the	the	DET
ajlsi-2730	153	13	risk	risk	NOUN
ajlsi-2730	153	14	of	of	ADP
ajlsi-2730	153	15	developing	develop	VERB
ajlsi-2730	153	16	cancers	cancer	NOUN
ajlsi-2730	153	17	.	.	PUNCT
ajlsi-2730	154	1	limitations	limitation	NOUN
ajlsi-2730	154	2	➢	➢	VERB
ajlsi-2730	154	3	the	the	DET
ajlsi-2730	154	4	study	study	NOUN
ajlsi-2730	154	5	has	have	VERB
ajlsi-2730	154	6	a	a	DET
ajlsi-2730	154	7	limited	limited	ADJ
ajlsi-2730	154	8	sample	sample	NOUN
ajlsi-2730	154	9	size	size	NOUN
ajlsi-2730	154	10	,	,	PUNCT
ajlsi-2730	154	11	which	which	PRON
ajlsi-2730	154	12	could	could	AUX
ajlsi-2730	154	13	affect	affect	VERB
ajlsi-2730	154	14	the	the	DET
ajlsi-2730	154	15	generalizability	generalizability	NOUN
ajlsi-2730	154	16	of	of	ADP
ajlsi-2730	154	17	the	the	DET
ajlsi-2730	154	18	findings	finding	NOUN
ajlsi-2730	154	19	to	to	ADP
ajlsi-2730	154	20	a	a	DET
ajlsi-2730	154	21	broader	broad	ADJ
ajlsi-2730	154	22	population	population	NOUN
ajlsi-2730	154	23	.	.	PUNCT
ajlsi-2730	155	1	➢	➢	VERB
ajlsi-2730	155	2	the	the	DET
ajlsi-2730	155	3	cost	cost	NOUN
ajlsi-2730	155	4	of	of	ADP
ajlsi-2730	155	5	secukinumab	secukinumab	NOUN
ajlsi-2730	155	6	and	and	CCONJ
ajlsi-2730	155	7	its	its	PRON
ajlsi-2730	155	8	accessibility	accessibility	NOUN
ajlsi-2730	155	9	to	to	ADP
ajlsi-2730	155	10	all	all	DET
ajlsi-2730	155	11	patients	patient	NOUN
ajlsi-2730	155	12	,	,	PUNCT
ajlsi-2730	155	13	especially	especially	ADV
ajlsi-2730	155	14	in	in	ADP
ajlsi-2730	155	15	regions	region	NOUN
ajlsi-2730	155	16	with	with	ADP
ajlsi-2730	155	17	limited	limited	ADJ
ajlsi-2730	155	18	healthcare	healthcare	NOUN
ajlsi-2730	155	19	resources	resource	NOUN
ajlsi-2730	155	20	,	,	PUNCT
ajlsi-2730	155	21	could	could	AUX
ajlsi-2730	155	22	impact	impact	VERB
ajlsi-2730	155	23	its	its	PRON
ajlsi-2730	155	24	applicability	applicability	NOUN
ajlsi-2730	155	25	in	in	ADP
ajlsi-2730	155	26	real	real	ADJ
ajlsi-2730	155	27	-	-	PUNCT
ajlsi-2730	155	28	world	world	NOUN
ajlsi-2730	155	29	settings	setting	NOUN
ajlsi-2730	155	30	.	.	PUNCT
ajlsi-2730	156	1	conclusion	conclusion	NOUN
ajlsi-2730	156	2	in	in	ADP
ajlsi-2730	156	3	conclusion	conclusion	NOUN
ajlsi-2730	156	4	,	,	PUNCT
ajlsi-2730	156	5	this	this	DET
ajlsi-2730	156	6	study	study	NOUN
ajlsi-2730	156	7	demonstrated	demonstrate	VERB
ajlsi-2730	156	8	the	the	DET
ajlsi-2730	156	9	ability	ability	NOUN
ajlsi-2730	156	10	to	to	PART
ajlsi-2730	156	11	effectively	effectively	ADV
ajlsi-2730	156	12	improve	improve	VERB
ajlsi-2730	156	13	the	the	DET
ajlsi-2730	156	14	skin	skin	NOUN
ajlsi-2730	156	15	texture	texture	NOUN
ajlsi-2730	156	16	scaling	scaling	NOUN
ajlsi-2730	156	17	area	area	NOUN
ajlsi-2730	156	18	severity	severity	NOUN
ajlsi-2730	156	19	index	index	NOUN
ajlsi-2730	156	20	via	via	ADP
ajlsi-2730	156	21	secukinumab	secukinumab	NOUN
ajlsi-2730	156	22	,	,	PUNCT
ajlsi-2730	156	23	which	which	PRON
ajlsi-2730	156	24	may	may	AUX
ajlsi-2730	156	25	have	have	VERB
ajlsi-2730	156	26	clinical	clinical	ADJ
ajlsi-2730	156	27	applications	application	NOUN
ajlsi-2730	156	28	.	.	PUNCT
ajlsi-2730	157	1	these	these	DET
ajlsi-2730	157	2	results	result	NOUN
ajlsi-2730	157	3	highlight	highlight	VERB
ajlsi-2730	157	4	the	the	DET
ajlsi-2730	157	5	potential	potential	NOUN
ajlsi-2730	157	6	of	of	ADP
ajlsi-2730	157	7	secukinumab	secukinumab	NOUN
ajlsi-2730	157	8	to	to	PART
ajlsi-2730	157	9	serve	serve	VERB
ajlsi-2730	157	10	as	as	ADP
ajlsi-2730	157	11	an	an	DET
ajlsi-2730	157	12	efficient	efficient	ADJ
ajlsi-2730	157	13	and	and	CCONJ
ajlsi-2730	157	14	protective	protective	ADJ
ajlsi-2730	157	15	agent	agent	NOUN
ajlsi-2730	157	16	against	against	ADP
ajlsi-2730	157	17	all	all	DET
ajlsi-2730	157	18	types	type	NOUN
ajlsi-2730	157	19	of	of	ADP
ajlsi-2730	157	20	ichthyosis	ichthyosis	NOUN
ajlsi-2730	157	21	,	,	PUNCT
ajlsi-2730	157	22	including	include	VERB
ajlsi-2730	157	23	lamellar	lamellar	ADJ
ajlsi-2730	157	24	,	,	PUNCT
ajlsi-2730	157	25	x	x	X
ajlsi-2730	157	26	-	-	VERB
ajlsi-2730	157	27	linked	link	VERB
ajlsi-2730	157	28	,	,	PUNCT
ajlsi-2730	157	29	and	and	CCONJ
ajlsi-2730	157	30	vulgaris	vulgaris	NOUN
ajlsi-2730	157	31	.	.	PUNCT
ajlsi-2730	158	1	this	this	DET
ajlsi-2730	158	2	study	study	NOUN
ajlsi-2730	158	3	provides	provide	VERB
ajlsi-2730	158	4	valuable	valuable	ADJ
ajlsi-2730	158	5	information	information	NOUN
ajlsi-2730	158	6	regarding	regard	VERB
ajlsi-2730	158	7	the	the	DET
ajlsi-2730	158	8	effects	effect	NOUN
ajlsi-2730	158	9	of	of	ADP
ajlsi-2730	158	10	secukinumab	secukinumab	NOUN
ajlsi-2730	158	11	relative	relative	ADJ
ajlsi-2730	158	12	to	to	ADP
ajlsi-2730	158	13	placebo	placebo	NOUN
ajlsi-2730	158	14	and	and	CCONJ
ajlsi-2730	158	15	over	over	ADP
ajlsi-2730	158	16	the	the	DET
ajlsi-2730	158	17	already	already	ADV
ajlsi-2730	158	18	studied	study	VERB
ajlsi-2730	158	19	outcomes	outcome	NOUN
ajlsi-2730	158	20	of	of	ADP
ajlsi-2730	158	21	other	other	ADJ
ajlsi-2730	158	22	il-17	il-17	NOUN
ajlsi-2730	158	23	-	-	PUNCT
ajlsi-2730	158	24	a	a	DET
ajlsi-2730	158	25	inhibitors	inhibitor	NOUN
ajlsi-2730	158	26	,	,	PUNCT
ajlsi-2730	158	27	including	include	VERB
ajlsi-2730	158	28	ixekizumab	ixekizumab	NOUN
ajlsi-2730	158	29	and	and	CCONJ
ajlsi-2730	158	30	brodalumab	brodalumab	NOUN
ajlsi-2730	158	31	,	,	PUNCT
ajlsi-2730	158	32	and	and	CCONJ
ajlsi-2730	158	33	its	its	PRON
ajlsi-2730	158	34	potential	potential	ADJ
ajlsi-2730	158	35	clinical	clinical	ADJ
ajlsi-2730	158	36	applications	application	NOUN
ajlsi-2730	158	37	.	.	PUNCT
ajlsi-2730	159	1	clinical	clinical	ADJ
ajlsi-2730	159	2	implications	implication	NOUN
ajlsi-2730	159	3	the	the	DET
ajlsi-2730	159	4	results	result	NOUN
ajlsi-2730	159	5	obtained	obtain	VERB
ajlsi-2730	159	6	from	from	ADP
ajlsi-2730	159	7	the	the	DET
ajlsi-2730	159	8	present	present	ADJ
ajlsi-2730	159	9	research	research	NOUN
ajlsi-2730	159	10	study	study	NOUN
ajlsi-2730	159	11	could	could	AUX
ajlsi-2730	159	12	be	be	AUX
ajlsi-2730	159	13	valuable	valuable	ADJ
ajlsi-2730	159	14	for	for	ADP
ajlsi-2730	159	15	clinical	clinical	ADJ
ajlsi-2730	159	16	practitioners	practitioner	NOUN
ajlsi-2730	159	17	in	in	ADP
ajlsi-2730	159	18	public	public	ADJ
ajlsi-2730	159	19	health	health	NOUN
ajlsi-2730	159	20	care	care	NOUN
ajlsi-2730	159	21	,	,	PUNCT
ajlsi-2730	159	22	particularly	particularly	ADV
ajlsi-2730	159	23	pediatricians	pediatrician	NOUN
ajlsi-2730	159	24	,	,	PUNCT
ajlsi-2730	159	25	as	as	SCONJ
ajlsi-2730	159	26	they	they	PRON
ajlsi-2730	159	27	may	may	AUX
ajlsi-2730	159	28	consider	consider	VERB
ajlsi-2730	159	29	incorporating	incorporate	VERB
ajlsi-2730	159	30	secukinumab	secukinumab	NOUN
ajlsi-2730	159	31	into	into	ADP
ajlsi-2730	159	32	the	the	DET
ajlsi-2730	159	33	treatment	treatment	NOUN
ajlsi-2730	159	34	regimen	regiman	NOUN
ajlsi-2730	159	35	for	for	ADP
ajlsi-2730	159	36	ichthyosis	ichthyosis	NOUN
ajlsi-2730	159	37	,	,	PUNCT
ajlsi-2730	159	38	leading	lead	VERB
ajlsi-2730	159	39	to	to	ADP
ajlsi-2730	159	40	improved	improved	ADJ
ajlsi-2730	159	41	area	area	NOUN
ajlsi-2730	159	42	severity	severity	NOUN
ajlsi-2730	159	43	index	index	NOUN
ajlsi-2730	159	44	scores	score	NOUN
ajlsi-2730	159	45	and	and	CCONJ
ajlsi-2730	159	46	enhanced	enhance	VERB
ajlsi-2730	159	47	safety	safety	NOUN
ajlsi-2730	159	48	for	for	ADP
ajlsi-2730	159	49	pediatric	pediatric	ADJ
ajlsi-2730	159	50	patients	patient	NOUN
ajlsi-2730	159	51	.	.	PUNCT
ajlsi-2730	160	1	future	future	ADJ
ajlsi-2730	160	2	directions	direction	NOUN
ajlsi-2730	160	3	➢	➢	VERB
ajlsi-2730	160	4	conduct	conduct	VERB
ajlsi-2730	160	5	longitudinal	longitudinal	ADJ
ajlsi-2730	160	6	research	research	NOUN
ajlsi-2730	160	7	to	to	PART
ajlsi-2730	160	8	evaluate	evaluate	VERB
ajlsi-2730	160	9	the	the	DET
ajlsi-2730	160	10	longterm	longterm	ADJ
ajlsi-2730	160	11	effectiveness	effectiveness	NOUN
ajlsi-2730	160	12	and	and	CCONJ
ajlsi-2730	160	13	safety	safety	NOUN
ajlsi-2730	160	14	profile	profile	NOUN
ajlsi-2730	160	15	of	of	ADP
ajlsi-2730	160	16	secukinumab	secukinumab	NOUN
ajlsi-2730	160	17	in	in	ADP
ajlsi-2730	160	18	pediatric	pediatric	ADJ
ajlsi-2730	160	19	patients	patient	NOUN
ajlsi-2730	160	20	with	with	ADP
ajlsi-2730	160	21	ichthyosis	ichthyosis	NOUN
ajlsi-2730	160	22	.	.	PUNCT
ajlsi-2730	161	1	a	a	DET
ajlsi-2730	161	2	minimum	minimum	ADJ
ajlsi-2730	161	3	12	12	NUM
ajlsi-2730	161	4	-	-	PUNCT
ajlsi-2730	161	5	month	month	NOUN
ajlsi-2730	161	6	follow	follow	NOUN
ajlsi-2730	161	7	-	-	PUNCT
ajlsi-2730	161	8	up	up	NOUN
ajlsi-2730	161	9	period	period	NOUN
ajlsi-2730	161	10	should	should	AUX
ajlsi-2730	161	11	be	be	AUX
ajlsi-2730	161	12	a	a	DET
ajlsi-2730	161	13	part	part	NOUN
ajlsi-2730	161	14	of	of	ADP
ajlsi-2730	161	15	this	this	DET
ajlsi-2730	161	16	study	study	NOUN
ajlsi-2730	161	17	to	to	PART
ajlsi-2730	161	18	assess	assess	VERB
ajlsi-2730	161	19	the	the	DET
ajlsi-2730	161	20	treatment	treatment	NOUN
ajlsi-2730	161	21	’s	’s	PART
ajlsi-2730	161	22	long	long	ADJ
ajlsi-2730	161	23	-	-	PUNCT
ajlsi-2730	161	24	term	term	NOUN
ajlsi-2730	161	25	effectiveness	effectiveness	NOUN
ajlsi-2730	161	26	and	and	CCONJ
ajlsi-2730	161	27	any	any	DET
ajlsi-2730	161	28	possible	possible	ADJ
ajlsi-2730	161	29	side	side	NOUN
ajlsi-2730	161	30	effects	effect	NOUN
ajlsi-2730	161	31	.	.	PUNCT
ajlsi-2730	162	1	➢	➢	PROPN
ajlsi-2730	162	2	recommended	recommend	VERB
ajlsi-2730	162	3	to	to	PART
ajlsi-2730	162	4	examine	examine	VERB
ajlsi-2730	162	5	if	if	SCONJ
ajlsi-2730	162	6	it	it	PRON
ajlsi-2730	162	7	would	would	AUX
ajlsi-2730	162	8	be	be	AUX
ajlsi-2730	162	9	advantageous	advantageous	ADJ
ajlsi-2730	162	10	to	to	PART
ajlsi-2730	162	11	treat	treat	VERB
ajlsi-2730	162	12	pediatric	pediatric	ADJ
ajlsi-2730	162	13	patients	patient	NOUN
ajlsi-2730	162	14	with	with	ADP
ajlsi-2730	162	15	ichthyosis	ichthyosis	NOUN
ajlsi-2730	162	16	with	with	ADP
ajlsi-2730	162	17	secukinumab	secukinumab	NOUN
ajlsi-2730	162	18	in	in	ADP
ajlsi-2730	162	19	addition	addition	NOUN
ajlsi-2730	162	20	to	to	ADP
ajlsi-2730	162	21	other	other	ADJ
ajlsi-2730	162	22	therapies	therapy	NOUN
ajlsi-2730	162	23	like	like	ADP
ajlsi-2730	162	24	topical	topical	ADJ
ajlsi-2730	162	25	corticosteroids	corticosteroid	NOUN
ajlsi-2730	162	26	,	,	PUNCT
ajlsi-2730	162	27	emollients	emollient	NOUN
ajlsi-2730	162	28	,	,	PUNCT
ajlsi-2730	162	29	or	or	CCONJ
ajlsi-2730	162	30	phototherapy	phototherapy	NOUN
ajlsi-2730	162	31	.	.	PUNCT
ajlsi-2730	163	1	optimizing	optimize	VERB
ajlsi-2730	163	2	treatment	treatment	NOUN
ajlsi-2730	163	3	outcomes	outcome	NOUN
ajlsi-2730	163	4	using	use	VERB
ajlsi-2730	163	5	a	a	DET
ajlsi-2730	163	6	combined	combine	VERB
ajlsi-2730	163	7	strategy	strategy	NOUN
ajlsi-2730	163	8	could	could	AUX
ajlsi-2730	163	9	result	result	VERB
ajlsi-2730	163	10	in	in	ADP
ajlsi-2730	163	11	synergistic	synergistic	ADJ
ajlsi-2730	163	12	effects	effect	NOUN
ajlsi-2730	163	13	.	.	PUNCT
ajlsi-2730	164	1	references	reference	NOUN
ajlsi-2730	164	2	afshan	afshan	NOUN
ajlsi-2730	164	3	,	,	PUNCT
ajlsi-2730	164	4	t.	t.	PROPN
ajlsi-2730	164	5	,	,	PUNCT
ajlsi-2730	164	6	&	&	CCONJ
ajlsi-2730	164	7	kelbel	kelbel	PROPN
ajlsi-2730	164	8	,	,	PUNCT
ajlsi-2730	164	9	t.	t.	PROPN
ajlsi-2730	164	10	(	(	PUNCT
ajlsi-2730	164	11	2019	2019	NUM
ajlsi-2730	164	12	)	)	PUNCT
ajlsi-2730	164	13	.	.	PUNCT
ajlsi-2730	165	1	m501	m501	VERB
ajlsi-2730	165	2	an	an	DET
ajlsi-2730	165	3	adolescent	adolescent	ADJ
ajlsi-2730	165	4	patient	patient	NOUN
ajlsi-2730	165	5	with	with	ADP
ajlsi-2730	165	6	krt10	krt10	NOUN
ajlsi-2730	165	7	mutation	mutation	NOUN
ajlsi-2730	165	8	-	-	PUNCT
ajlsi-2730	165	9	associated	associate	VERB
ajlsi-2730	165	10	ichthyosis	ichthyosis	NOUN
ajlsi-2730	165	11	successfully	successfully	ADV
ajlsi-2730	165	12	treated	treat	VERB
ajlsi-2730	165	13	with	with	ADP
ajlsi-2730	165	14	dupilumab	dupilumab	NOUN
ajlsi-2730	165	15	.	.	PUNCT
ajlsi-2730	166	1	annals	annal	NOUN
ajlsi-2730	166	2	of	of	ADP
ajlsi-2730	166	3	allergy	allergy	NOUN
ajlsi-2730	166	4	,	,	PUNCT
ajlsi-2730	166	5	asthma	asthma	PROPN
ajlsi-2730	166	6	&	&	CCONJ
ajlsi-2730	166	7	immunology	immunology	NOUN
ajlsi-2730	166	8	,	,	PUNCT
ajlsi-2730	166	9	123(5	123(5	NUM
ajlsi-2730	166	10	)	)	PUNCT
ajlsi-2730	166	11	,	,	PUNCT
ajlsi-2730	166	12	s139	s139	PROPN
ajlsi-2730	166	13	.	.	PROPN
ajlsi-2730	166	14	albela	albela	PROPN
ajlsi-2730	166	15	,	,	PUNCT
ajlsi-2730	166	16	h.	h.	PROPN
ajlsi-2730	166	17	,	,	PUNCT
ajlsi-2730	166	18	ingrid	ingrid	PROPN
ajlsi-2730	166	19	pao	pao	PROPN
ajlsi-2730	166	20	lin	lin	PROPN
ajlsi-2730	166	21	,	,	PUNCT
ajlsi-2730	166	22	t.	t.	PROPN
ajlsi-2730	166	23	,	,	PUNCT
ajlsi-2730	166	24	lee	lee	PROPN
ajlsi-2730	166	25	,	,	PUNCT
ajlsi-2730	166	26	t.	t.	PROPN
ajlsi-2730	166	27	s.	s.	PROPN
ajlsi-2730	166	28	,	,	PUNCT
ajlsi-2730	166	29	ooi	ooi	PROPN
ajlsi-2730	166	30	,	,	PUNCT
ajlsi-2730	166	31	d.	d.	PROPN
ajlsi-2730	166	32	,	,	PUNCT
ajlsi-2730	166	33	&	&	CCONJ
ajlsi-2730	166	34	leong	leong	PROPN
ajlsi-2730	166	35	,	,	PUNCT
ajlsi-2730	166	36	k.	k.	PROPN
ajlsi-2730	166	37	f.	f.	PROPN
ajlsi-2730	166	38	(	(	PUNCT
ajlsi-2730	166	39	2024	2024	NUM
ajlsi-2730	166	40	)	)	PUNCT
ajlsi-2730	166	41	.	.	PUNCT
ajlsi-2730	167	1	secukinumab	secukinumab	NOUN
ajlsi-2730	167	2	therapy	therapy	NOUN
ajlsi-2730	167	3	for	for	ADP
ajlsi-2730	167	4	paediatric	paediatric	ADJ
ajlsi-2730	167	5	patients	patient	NOUN
ajlsi-2730	167	6	with	with	ADP
ajlsi-2730	167	7	various	various	ADJ
ajlsi-2730	167	8	phenotypes	phenotype	NOUN
ajlsi-2730	167	9	of	of	ADP
ajlsi-2730	167	10	congenital	congenital	ADJ
ajlsi-2730	167	11	ichthyosis	ichthyosis	NOUN
ajlsi-2730	167	12	.	.	PUNCT
ajlsi-2730	168	1	clinical	clinical	ADJ
ajlsi-2730	168	2	and	and	CCONJ
ajlsi-2730	168	3	experimental	experimental	ADJ
ajlsi-2730	168	4	dermatology	dermatology	NOUN
ajlsi-2730	168	5	,	,	PUNCT
ajlsi-2730	168	6	llae082	llae082	PROPN
ajlsi-2730	168	7	.	.	PROPN
ajlsi-2730	168	8	almuhanna	almuhanna	PROPN
ajlsi-2730	168	9	,	,	PUNCT
ajlsi-2730	168	10	n.	n.	NOUN
ajlsi-2730	168	11	,	,	PUNCT
ajlsi-2730	168	12	alasmari	alasmari	PROPN
ajlsi-2730	168	13	,	,	PUNCT
ajlsi-2730	168	14	b.	b.	PROPN
ajlsi-2730	168	15	s.	s.	PROPN
ajlsi-2730	168	16	,	,	PUNCT
ajlsi-2730	168	17	alhamazani	alhamazani	PROPN
ajlsi-2730	168	18	,	,	PUNCT
ajlsi-2730	168	19	r.	r.	PROPN
ajlsi-2730	168	20	,	,	PUNCT
ajlsi-2730	168	21	alkhezzi	alkhezzi	PROPN
ajlsi-2730	168	22	,	,	PUNCT
ajlsi-2730	168	23	s.	s.	PROPN
ajlsi-2730	168	24	,	,	PUNCT
ajlsi-2730	168	25	alhomida	alhomida	PROPN
ajlsi-2730	168	26	,	,	PUNCT
ajlsi-2730	168	27	f.	f.	PROPN
ajlsi-2730	168	28	a.	a.	PROPN
ajlsi-2730	168	29	,	,	PUNCT
ajlsi-2730	168	30	alasmari	alasmari	PROPN
ajlsi-2730	168	31	,	,	PUNCT
ajlsi-2730	168	32	b.	b.	PROPN
ajlsi-2730	168	33	,	,	PUNCT
ajlsi-2730	168	34	&	&	CCONJ
ajlsi-2730	168	35	alshammari	alshammari	PROPN
ajlsi-2730	168	36	,	,	PUNCT
ajlsi-2730	168	37	r.	r.	PROPN
ajlsi-2730	168	38	(	(	PUNCT
ajlsi-2730	168	39	2023	2023	NUM
ajlsi-2730	168	40	)	)	PUNCT
ajlsi-2730	168	41	.	.	PUNCT
ajlsi-2730	169	1	assessing	assess	VERB
ajlsi-2730	169	2	the	the	DET
ajlsi-2730	169	3	use	use	NOUN
ajlsi-2730	169	4	of	of	ADP
ajlsi-2730	169	5	ustekinumab	ustekinumab	NOUN
ajlsi-2730	169	6	in	in	ADP
ajlsi-2730	169	7	a	a	DET
ajlsi-2730	169	8	pediatric	pediatric	ADJ
ajlsi-2730	169	9	patient	patient	NOUN
ajlsi-2730	169	10	with	with	ADP
ajlsi-2730	169	11	harlequin	harlequin	PROPN
ajlsi-2730	169	12	ichthyosis	ichthyosis	NOUN
ajlsi-2730	169	13	.	.	PUNCT
ajlsi-2730	170	1	cureus	cureus	NOUN
ajlsi-2730	170	2	,	,	PUNCT
ajlsi-2730	170	3	15(4	15(4	NUM
ajlsi-2730	170	4	)	)	PUNCT
ajlsi-2730	170	5	.	.	PUNCT
ajlsi-2730	171	1	almuhanna	almuhanna	PROPN
ajlsi-2730	171	2	,	,	PUNCT
ajlsi-2730	171	3	n.	n.	NOUN
ajlsi-2730	171	4	,	,	PUNCT
ajlsi-2730	171	5	alrashidi	alrashidi	NOUN
ajlsi-2730	171	6	,	,	PUNCT
ajlsi-2730	171	7	a.	a.	PROPN
ajlsi-2730	171	8	r.	r.	PROPN
ajlsi-2730	171	9	,	,	PUNCT
ajlsi-2730	171	10	shaheen	shaheen	PROPN
ajlsi-2730	171	11	,	,	PUNCT
ajlsi-2730	171	12	e.	e.	PROPN
ajlsi-2730	171	13	a.	a.	PROPN
ajlsi-2730	171	14	,	,	PUNCT
ajlsi-2730	171	15	alanazi	alanazi	PROPN
ajlsi-2730	171	16	,	,	PUNCT
ajlsi-2730	171	17	y.	y.	PROPN
ajlsi-2730	171	18	,	,	PUNCT
ajlsi-2730	171	19	alfawzan	alfawzan	PROPN
ajlsi-2730	171	20	,	,	PUNCT
ajlsi-2730	171	21	a.	a.	NOUN
ajlsi-2730	171	22	,	,	PUNCT
ajlsi-2730	171	23	alharthi	alharthi	PROPN
ajlsi-2730	171	24	,	,	PUNCT
ajlsi-2730	171	25	r.	r.	PROPN
ajlsi-2730	171	26	,	,	PUNCT
ajlsi-2730	171	27	&	&	CCONJ
ajlsi-2730	171	28	alhomida	alhomida	PROPN
ajlsi-2730	171	29	,	,	PUNCT
ajlsi-2730	171	30	f.	f.	PROPN
ajlsi-2730	171	31	a.	a.	PROPN
ajlsi-2730	171	32	(	(	PUNCT
ajlsi-2730	171	33	2023	2023	NUM
ajlsi-2730	171	34	)	)	PUNCT
ajlsi-2730	171	35	.	.	PUNCT
ajlsi-2730	172	1	assessing	assess	VERB
ajlsi-2730	172	2	the	the	DET
ajlsi-2730	172	3	use	use	NOUN
ajlsi-2730	172	4	of	of	ADP
ajlsi-2730	172	5	dupilumab	dupilumab	NOUN
ajlsi-2730	172	6	in	in	ADP
ajlsi-2730	172	7	a	a	DET
ajlsi-2730	172	8	pediatric	pediatric	ADJ
ajlsi-2730	172	9	patient	patient	NOUN
ajlsi-2730	172	10	with	with	ADP
ajlsi-2730	172	11	bullous	bullous	ADJ
ajlsi-2730	172	12	congenital	congenital	ADJ
ajlsi-2730	172	13	ichthyosiform	ichthyosiform	NOUN
ajlsi-2730	172	14	erythroderma	erythroderma	NOUN
ajlsi-2730	172	15	.	.	PUNCT
ajlsi-2730	173	1	jaad	jaad	NOUN
ajlsi-2730	173	2	case	case	NOUN
ajlsi-2730	173	3	reports	report	NOUN
ajlsi-2730	173	4	,	,	PUNCT
ajlsi-2730	173	5	39	39	NUM
ajlsi-2730	173	6	,	,	PUNCT
ajlsi-2730	173	7	17	17	NUM
ajlsi-2730	173	8	-	-	SYM
ajlsi-2730	173	9	20	20	NUM
ajlsi-2730	173	10	.	.	PUNCT
ajlsi-2730	174	1	baldo	baldo	PROPN
ajlsi-2730	174	2	,	,	PUNCT
ajlsi-2730	174	3	f.	f.	PROPN
ajlsi-2730	174	4	,	,	PUNCT
ajlsi-2730	174	5	brena	brena	PROPN
ajlsi-2730	174	6	,	,	PUNCT
ajlsi-2730	174	7	m.	m.	NOUN
ajlsi-2730	174	8	,	,	PUNCT
ajlsi-2730	174	9	carbogno	carbogno	NOUN
ajlsi-2730	174	10	,	,	PUNCT
ajlsi-2730	174	11	s.	s.	PROPN
ajlsi-2730	174	12	,	,	PUNCT
ajlsi-2730	174	13	minoia	minoia	PROPN
ajlsi-2730	174	14	,	,	PUNCT
ajlsi-2730	174	15	f.	f.	PROPN
ajlsi-2730	174	16	,	,	PUNCT
ajlsi-2730	174	17	lanni	lanni	PROPN
ajlsi-2730	174	18	,	,	PUNCT
ajlsi-2730	174	19	s.	s.	PROPN
ajlsi-2730	174	20	,	,	PUNCT
ajlsi-2730	174	21	guez	guez	PROPN
ajlsi-2730	174	22	,	,	PUNCT
ajlsi-2730	174	23	s.	s.	PROPN
ajlsi-2730	174	24	,	,	PUNCT
ajlsi-2730	174	25	petaccia	petaccia	PROPN
ajlsi-2730	174	26	,	,	PUNCT
ajlsi-2730	174	27	a.	a.	NOUN
ajlsi-2730	174	28	,	,	PUNCT
ajlsi-2730	174	29	agostoni	agostoni	NOUN
ajlsi-2730	174	30	,	,	PUNCT
ajlsi-2730	174	31	c.	c.	NOUN
ajlsi-2730	174	32	,	,	PUNCT
ajlsi-2730	174	33	cimaz	cimaz	PROPN
ajlsi-2730	174	34	,	,	PUNCT
ajlsi-2730	174	35	r.	r.	PROPN
ajlsi-2730	174	36	,	,	PUNCT
ajlsi-2730	174	37	&	&	CCONJ
ajlsi-2730	174	38	filocamo	filocamo	PROPN
ajlsi-2730	174	39	,	,	PUNCT
ajlsi-2730	174	40	g.	g.	PROPN
ajlsi-2730	174	41	(	(	PUNCT
ajlsi-2730	174	42	2021	2021	NUM
ajlsi-2730	174	43	)	)	PUNCT
ajlsi-2730	174	44	.	.	PUNCT
ajlsi-2730	175	1	juvenile	juvenile	ADJ
ajlsi-2730	175	2	idiopathic	idiopathic	ADJ
ajlsi-2730	175	3	arthritis	arthritis	NOUN
ajlsi-2730	175	4	in	in	ADP
ajlsi-2730	175	5	harlequin	harlequin	PROPN
ajlsi-2730	175	6	ichthyosis	ichthyosis	NOUN
ajlsi-2730	175	7	,	,	PUNCT
ajlsi-2730	175	8	a	a	DET
ajlsi-2730	175	9	rare	rare	ADJ
ajlsi-2730	175	10	combination	combination	NOUN
ajlsi-2730	175	11	or	or	CCONJ
ajlsi-2730	175	12	the	the	DET
ajlsi-2730	175	13	clinical	clinical	ADJ
ajlsi-2730	175	14	spectrum	spectrum	NOUN
ajlsi-2730	175	15	of	of	ADP
ajlsi-2730	175	16	the	the	DET
ajlsi-2730	175	17	disease	disease	NOUN
ajlsi-2730	175	18	?	?	PUNCT
ajlsi-2730	176	1	report	report	NOUN
ajlsi-2730	176	2	of	of	ADP
ajlsi-2730	176	3	a	a	DET
ajlsi-2730	176	4	child	child	NOUN
ajlsi-2730	176	5	treated	treat	VERB
ajlsi-2730	176	6	with	with	ADP
ajlsi-2730	176	7	etanercept	etanercept	NOUN
ajlsi-2730	176	8	and	and	CCONJ
ajlsi-2730	176	9	review	review	NOUN
ajlsi-2730	176	10	of	of	ADP
ajlsi-2730	176	11	the	the	DET
ajlsi-2730	176	12	literature	literature	NOUN
ajlsi-2730	176	13	.	.	PUNCT
ajlsi-2730	177	1	pediatric	pediatric	ADJ
ajlsi-2730	177	2	rheumatology	rheumatology	NOUN
ajlsi-2730	177	3	,	,	PUNCT
ajlsi-2730	177	4	19(1	19(1	NUM
ajlsi-2730	177	5	)	)	PUNCT
ajlsi-2730	177	6	,	,	PUNCT
ajlsi-2730	177	7	80	80	NUM
ajlsi-2730	177	8	.	.	PUNCT
ajlsi-2730	178	1	barbati	barbati	PROPN
ajlsi-2730	178	2	,	,	PUNCT
ajlsi-2730	178	3	f.	f.	PROPN
ajlsi-2730	178	4	,	,	PUNCT
ajlsi-2730	178	5	giovannini	giovannini	PROPN
ajlsi-2730	178	6	,	,	PUNCT
ajlsi-2730	178	7	m.	m.	NOUN
ajlsi-2730	178	8	,	,	PUNCT
ajlsi-2730	178	9	oranges	orange	NOUN
ajlsi-2730	178	10	,	,	PUNCT
ajlsi-2730	178	11	t.	t.	PROPN
ajlsi-2730	178	12	,	,	PUNCT
ajlsi-2730	178	13	lodi	lodi	PROPN
ajlsi-2730	178	14	,	,	PUNCT
ajlsi-2730	178	15	l.	l.	PROPN
ajlsi-2730	178	16	,	,	PUNCT
ajlsi-2730	178	17	barni	barni	PROPN
ajlsi-2730	178	18	,	,	PUNCT
ajlsi-2730	178	19	s.	s.	PROPN
ajlsi-2730	178	20	,	,	PUNCT
ajlsi-2730	178	21	novembre	novembre	PROPN
ajlsi-2730	178	22	,	,	PUNCT
ajlsi-2730	178	23	e.	e.	PROPN
ajlsi-2730	178	24	,	,	PUNCT
ajlsi-2730	178	25	baldo	baldo	PROPN
ajlsi-2730	178	26	,	,	PUNCT
ajlsi-2730	178	27	e.	e.	PROPN
ajlsi-2730	178	28	,	,	PUNCT
ajlsi-2730	178	29	cristofolini	cristofolini	PROPN
ajlsi-2730	178	30	,	,	PUNCT
ajlsi-2730	178	31	m.	m.	NOUN
ajlsi-2730	178	32	,	,	PUNCT
ajlsi-2730	178	33	stagi	stagi	PROPN
ajlsi-2730	178	34	,	,	PUNCT
ajlsi-2730	178	35	s.	s.	PROPN
ajlsi-2730	178	36	,	,	PUNCT
ajlsi-2730	178	37	&	&	CCONJ
ajlsi-2730	178	38	ricci	ricci	PROPN
ajlsi-2730	178	39	,	,	PUNCT
ajlsi-2730	178	40	s.	s.	PROPN
ajlsi-2730	178	41	(	(	PUNCT
ajlsi-2730	178	42	2021	2021	NUM
ajlsi-2730	178	43	)	)	PUNCT
ajlsi-2730	178	44	.	.	PUNCT
ajlsi-2730	179	1	netherton	netherton	PROPN
ajlsi-2730	179	2	syndrome	syndrome	NOUN
ajlsi-2730	179	3	in	in	ADP
ajlsi-2730	179	4	children	child	NOUN
ajlsi-2730	179	5	:	:	PUNCT
ajlsi-2730	179	6	management	management	NOUN
ajlsi-2730	179	7	and	and	CCONJ
ajlsi-2730	179	8	future	future	ADJ
ajlsi-2730	179	9	perspectives	perspective	NOUN
ajlsi-2730	179	10	.	.	PUNCT
ajlsi-2730	180	1	frontiers	frontier	NOUN
ajlsi-2730	180	2	in	in	ADP
ajlsi-2730	180	3	pediatrics	pediatric	NOUN
ajlsi-2730	180	4	,	,	PUNCT
ajlsi-2730	180	5	9	9	NUM
ajlsi-2730	180	6	,	,	PUNCT
ajlsi-2730	180	7	645259	645259	NUM
ajlsi-2730	180	8	.	.	PUNCT
ajlsi-2730	181	1	blanchet‐bardon	blanchet‐bardon	PROPN
ajlsi-2730	181	2	,	,	PUNCT
ajlsi-2730	181	3	c.	c.	PROPN
ajlsi-2730	181	4	,	,	PUNCT
ajlsi-2730	181	5	tadini	tadini	PROPN
ajlsi-2730	181	6	,	,	PUNCT
ajlsi-2730	181	7	g.	g.	PROPN
ajlsi-2730	181	8	,	,	PUNCT
ajlsi-2730	181	9	machado	machado	PROPN
ajlsi-2730	181	10	matos	matos	PROPN
ajlsi-2730	181	11	,	,	PUNCT
ajlsi-2730	181	12	m.	m.	NOUN
ajlsi-2730	181	13	,	,	PUNCT
ajlsi-2730	181	14	&	&	CCONJ
ajlsi-2730	181	15	delarue	delarue	PROPN
ajlsi-2730	181	16	,	,	PUNCT
ajlsi-2730	181	17	a.	a.	NOUN
ajlsi-2730	181	18	(	(	PUNCT
ajlsi-2730	181	19	2012	2012	NUM
ajlsi-2730	181	20	)	)	PUNCT
ajlsi-2730	181	21	.	.	PUNCT
ajlsi-2730	182	1	association	association	NOUN
ajlsi-2730	182	2	of	of	ADP
ajlsi-2730	182	3	glycerol	glycerol	NOUN
ajlsi-2730	182	4	and	and	CCONJ
ajlsi-2730	182	5	paraffin	paraffin	NOUN
ajlsi-2730	182	6	in	in	ADP
ajlsi-2730	182	7	the	the	DET
ajlsi-2730	182	8	treatment	treatment	NOUN
ajlsi-2730	182	9	of	of	ADP
ajlsi-2730	182	10	ichthyosis	ichthyosis	NOUN
ajlsi-2730	182	11	in	in	ADP
ajlsi-2730	182	12	children	child	NOUN
ajlsi-2730	182	13	:	:	PUNCT
ajlsi-2730	182	14	an	an	DET
ajlsi-2730	182	15	international	international	ADJ
ajlsi-2730	182	16	,	,	PUNCT
ajlsi-2730	182	17	multicentric	multicentric	NOUN
ajlsi-2730	182	18	,	,	PUNCT
ajlsi-2730	182	19	randomized	randomize	VERB
ajlsi-2730	182	20	,	,	PUNCT
ajlsi-2730	182	21	controlled	control	VERB
ajlsi-2730	182	22	,	,	PUNCT
ajlsi-2730	182	23	double‐blind	double‐blind	ADJ
ajlsi-2730	182	24	study	study	NOUN
ajlsi-2730	182	25	.	.	PUNCT
ajlsi-2730	183	1	journal	journal	NOUN
ajlsi-2730	183	2	of	of	ADP
ajlsi-2730	183	3	the	the	DET
ajlsi-2730	183	4	european	european	PROPN
ajlsi-2730	183	5	academy	academy	PROPN
ajlsi-2730	183	6	of	of	ADP
ajlsi-2730	183	7	dermatology	dermatology	NOUN
ajlsi-2730	183	8	and	and	CCONJ
ajlsi-2730	183	9	venereology	venereology	NOUN
ajlsi-2730	183	10	,	,	PUNCT
ajlsi-2730	183	11	26(8	26(8	NUM
ajlsi-2730	183	12	)	)	PUNCT
ajlsi-2730	183	13	,	,	PUNCT
ajlsi-2730	183	14	1014	1014	NUM
ajlsi-2730	183	15	-	-	SYM
ajlsi-2730	183	16	1019	1019	NUM
ajlsi-2730	183	17	.	.	PUNCT
ajlsi-2730	184	1	cicek	cicek	PROPN
ajlsi-2730	184	2	,	,	PUNCT
ajlsi-2730	184	3	f.	f.	PROPN
ajlsi-2730	184	4	,	,	PUNCT
ajlsi-2730	184	5	cekic	cekic	PROPN
ajlsi-2730	184	6	,	,	PUNCT
ajlsi-2730	184	7	s.	s.	PROPN
ajlsi-2730	184	8	,	,	PUNCT
ajlsi-2730	184	9	&	&	CCONJ
ajlsi-2730	184	10	kilic	kilic	PROPN
ajlsi-2730	184	11	,	,	PUNCT
ajlsi-2730	184	12	s.	s.	PROPN
ajlsi-2730	184	13	s.	s.	PROPN
ajlsi-2730	184	14	(	(	PUNCT
ajlsi-2730	184	15	2021	2021	NUM
ajlsi-2730	184	16	)	)	PUNCT
ajlsi-2730	184	17	.	.	PUNCT
ajlsi-2730	185	1	infliximab	infliximab	PROPN
ajlsi-2730	185	2	therapy	therapy	NOUN
ajlsi-2730	185	3	in	in	ADP
ajlsi-2730	185	4	an	an	DET
ajlsi-2730	185	5	infant	infant	NOUN
ajlsi-2730	185	6	with	with	ADP
ajlsi-2730	185	7	netherton	netherton	NOUN
ajlsi-2730	185	8	syndrome	syndrome	NOUN
ajlsi-2730	185	9	.	.	PUNCT
ajlsi-2730	186	1	pediatric	pediatric	ADJ
ajlsi-2730	186	2	dermatology	dermatology	NOUN
ajlsi-2730	186	3	,	,	PUNCT
ajlsi-2730	186	4	38(3	38(3	NUM
ajlsi-2730	186	5	)	)	PUNCT
ajlsi-2730	186	6	,	,	PUNCT
ajlsi-2730	186	7	714	714	NUM
ajlsi-2730	186	8	-	-	SYM
ajlsi-2730	186	9	716	716	NUM
ajlsi-2730	186	10	.	.	PUNCT
ajlsi-2730	187	1	cortés	cortés	PROPN
ajlsi-2730	187	2	,	,	PUNCT
ajlsi-2730	187	3	h.	h.	PROPN
ajlsi-2730	187	4	,	,	PUNCT
ajlsi-2730	187	5	del	del	PROPN
ajlsi-2730	187	6	prado	prado	PROPN
ajlsi-2730	187	7	-	-	PUNCT
ajlsi-2730	187	8	audelo	audelo	NOUN
ajlsi-2730	187	9	,	,	PUNCT
ajlsi-2730	187	10	m.	m.	NOUN
ajlsi-2730	187	11	l.	l.	PROPN
ajlsi-2730	187	12	,	,	PUNCT
ajlsi-2730	187	13	urbán	urbán	NOUN
ajlsi-2730	187	14	-	-	PUNCT
ajlsi-2730	187	15	morlán	morlán	NOUN
ajlsi-2730	187	16	,	,	PUNCT
ajlsi-2730	187	17	z.	z.	PROPN
ajlsi-2730	187	18	,	,	PUNCT
ajlsi-2730	187	19	alcalá	alcalá	NOUN
ajlsi-2730	187	20	-	-	PUNCT
ajlsi-2730	187	21	alcalá	alcalá	NOUN
ajlsi-2730	187	22	,	,	PUNCT
ajlsi-2730	187	23	s.	s.	PROPN
ajlsi-2730	187	24	,	,	PUNCT
ajlsi-2730	187	25	gonzález	gonzález	PROPN
ajlsi-2730	187	26	-	-	PUNCT
ajlsi-2730	187	27	torres	torre	NOUN
ajlsi-2730	187	28	,	,	PUNCT
ajlsi-2730	187	29	m.	m.	NOUN
ajlsi-2730	187	30	,	,	PUNCT
ajlsi-2730	187	31	reyeshernández	reyeshernández	PROPN
ajlsi-2730	187	32	,	,	PUNCT
ajlsi-2730	187	33	o.	o.	PROPN
ajlsi-2730	187	34	d.	d.	PROPN
ajlsi-2730	187	35	,	,	PUNCT
ajlsi-2730	187	36	gonzález	gonzález	PROPN
ajlsi-2730	187	37	-	-	PUNCT
ajlsi-2730	187	38	del	del	X
ajlsi-2730	187	39	carmen	carman	NOUN
ajlsi-2730	187	40	,	,	PUNCT
ajlsi-2730	187	41	m.	m.	NOUN
ajlsi-2730	187	42	,	,	PUNCT
ajlsi-2730	187	43	&	&	CCONJ
ajlsi-2730	187	44	leyva	leyva	PROPN
ajlsi-2730	187	45	-	-	PUNCT
ajlsi-2730	187	46	gómez	gómez	NOUN
ajlsi-2730	187	47	,	,	PUNCT
ajlsi-2730	187	48	g.	g.	PROPN
ajlsi-2730	187	49	(	(	PUNCT
ajlsi-2730	187	50	2020	2020	NUM
ajlsi-2730	187	51	)	)	PUNCT
ajlsi-2730	187	52	.	.	PUNCT
ajlsi-2730	188	1	pharmacological	pharmacological	ADJ
ajlsi-2730	188	2	treatments	treatment	NOUN
ajlsi-2730	188	3	for	for	ADP
ajlsi-2730	188	4	cutaneous	cutaneous	ADJ
ajlsi-2730	188	5	manifestations	manifestation	NOUN
ajlsi-2730	188	6	of	of	ADP
ajlsi-2730	188	7	inherited	inherit	VERB
ajlsi-2730	188	8	ichthyoses	ichthyose	NOUN
ajlsi-2730	188	9	.	.	PUNCT
ajlsi-2730	189	1	archives	archive	NOUN
ajlsi-2730	189	2	of	of	ADP
ajlsi-2730	189	3	dermatological	dermatological	ADJ
ajlsi-2730	189	4	research	research	NOUN
ajlsi-2730	189	5	,	,	PUNCT
ajlsi-2730	189	6	312	312	NUM
ajlsi-2730	189	7	,	,	PUNCT
ajlsi-2730	189	8	237	237	NUM
ajlsi-2730	189	9	-	-	SYM
ajlsi-2730	189	10	248	248	NUM
ajlsi-2730	189	11	.	.	PUNCT
ajlsi-2730	190	1	czarnowicki	czarnowicki	PROPN
ajlsi-2730	190	2	,	,	PUNCT
ajlsi-2730	190	3	t.	t.	PROPN
ajlsi-2730	190	4	,	,	PUNCT
ajlsi-2730	190	5	he	he	PRON
ajlsi-2730	190	6	,	,	PUNCT
ajlsi-2730	190	7	h.	h.	PROPN
ajlsi-2730	190	8	,	,	PUNCT
ajlsi-2730	190	9	leonard	leonard	PROPN
ajlsi-2730	190	10	,	,	PUNCT
ajlsi-2730	190	11	a.	a.	PROPN
ajlsi-2730	190	12	,	,	PUNCT
ajlsi-2730	190	13	malik	malik	PROPN
ajlsi-2730	190	14	,	,	PUNCT
ajlsi-2730	190	15	k.	k.	PROPN
ajlsi-2730	190	16	,	,	PUNCT
ajlsi-2730	190	17	magidi	magidi	PROPN
ajlsi-2730	190	18	,	,	PUNCT
ajlsi-2730	190	19	s.	s.	PROPN
ajlsi-2730	190	20	,	,	PUNCT
ajlsi-2730	190	21	rangel	rangel	PROPN
ajlsi-2730	190	22	,	,	PUNCT
ajlsi-2730	190	23	s.	s.	PROPN
ajlsi-2730	190	24	,	,	PUNCT
ajlsi-2730	190	25	patel	patel	PROPN
ajlsi-2730	190	26	,	,	PUNCT
ajlsi-2730	190	27	k.	k.	PROPN
ajlsi-2730	190	28	,	,	PUNCT
ajlsi-2730	190	29	ramsey	ramsey	PROPN
ajlsi-2730	190	30	,	,	PUNCT
ajlsi-2730	190	31	k.	k.	PROPN
ajlsi-2730	190	32	,	,	PUNCT
ajlsi-2730	190	33	murphrey	murphrey	PROPN
ajlsi-2730	190	34	,	,	PUNCT
ajlsi-2730	190	35	m.	m.	NOUN
ajlsi-2730	190	36	,	,	PUNCT
ajlsi-2730	190	37	&	&	CCONJ
ajlsi-2730	190	38	song	song	NOUN
ajlsi-2730	190	39	,	,	PUNCT
ajlsi-2730	190	40	t.	t.	PROPN
ajlsi-2730	190	41	(	(	PUNCT
ajlsi-2730	190	42	2018	2018	NUM
ajlsi-2730	190	43	)	)	PUNCT
ajlsi-2730	190	44	.	.	PUNCT
ajlsi-2730	191	1	the	the	DET
ajlsi-2730	191	2	major	major	ADJ
ajlsi-2730	191	3	orphan	orphan	NOUN
ajlsi-2730	191	4	forms	form	NOUN
ajlsi-2730	191	5	of	of	ADP
ajlsi-2730	191	6	ichthyosis	ichthyosis	NOUN
ajlsi-2730	191	7	are	be	AUX
ajlsi-2730	191	8	characterized	characterize	VERB
ajlsi-2730	191	9	by	by	ADP
ajlsi-2730	191	10	systemic	systemic	ADJ
ajlsi-2730	191	11	t	t	PROPN
ajlsi-2730	191	12	-	-	PUNCT
ajlsi-2730	191	13	cell	cell	NOUN
ajlsi-2730	191	14	activation	activation	NOUN
ajlsi-2730	191	15	and	and	CCONJ
ajlsi-2730	191	16	th17	th17	NOUN
ajlsi-2730	191	17	/	/	SYM
ajlsi-2730	191	18	tc-17	tc-17	NOUN
ajlsi-2730	191	19	/	/	SYM
ajlsi-2730	191	20	th-22	th-22	NUM
ajlsi-2730	191	21	/	/	SYM
ajlsi-2730	191	22	tc-22	tc-22	NUM
ajlsi-2730	192	1	polarization	polarization	NOUN
ajlsi-2730	192	2	in	in	ADP
ajlsi-2730	192	3	blood	blood	NOUN
ajlsi-2730	192	4	.	.	PUNCT
ajlsi-2730	193	1	journal	journal	NOUN
ajlsi-2730	193	2	of	of	ADP
ajlsi-2730	193	3	investigative	investigative	ADJ
ajlsi-2730	193	4	dermatology	dermatology	NOUN
ajlsi-2730	193	5	,	,	PUNCT
ajlsi-2730	193	6	138(10	138(10	NUM
ajlsi-2730	193	7	)	)	PUNCT
ajlsi-2730	193	8	,	,	PUNCT
ajlsi-2730	193	9	2157	2157	NUM
ajlsi-2730	193	10	-	-	SYM
ajlsi-2730	193	11	2167	2167	NUM
ajlsi-2730	193	12	.	.	PUNCT
ajlsi-2730	194	1	dyer	dyer	NOUN
ajlsi-2730	194	2	,	,	PUNCT
ajlsi-2730	194	3	j.	j.	PROPN
ajlsi-2730	194	4	a.	a.	PROPN
ajlsi-2730	194	5	,	,	PUNCT
ajlsi-2730	194	6	spraker	spraker	NOUN
ajlsi-2730	194	7	,	,	PUNCT
ajlsi-2730	194	8	m.	m.	NOUN
ajlsi-2730	194	9	,	,	PUNCT
ajlsi-2730	194	10	&	&	CCONJ
ajlsi-2730	194	11	williams	williams	PROPN
ajlsi-2730	194	12	,	,	PUNCT
ajlsi-2730	194	13	m.	m.	NOUN
ajlsi-2730	194	14	(	(	PUNCT
ajlsi-2730	194	15	2013	2013	NUM
ajlsi-2730	194	16	)	)	PUNCT
ajlsi-2730	194	17	.	.	PUNCT
ajlsi-2730	195	1	care	care	NOUN
ajlsi-2730	195	2	of	of	ADP
ajlsi-2730	195	3	the	the	DET
ajlsi-2730	195	4	newborn	newborn	ADJ
ajlsi-2730	195	5	with	with	ADP
ajlsi-2730	195	6	ichthyosis	ichthyosis	NOUN
ajlsi-2730	195	7	.	.	PUNCT
ajlsi-2730	196	1	dermatologic	dermatologic	ADJ
ajlsi-2730	196	2	therapy	therapy	NOUN
ajlsi-2730	196	3	,	,	PUNCT
ajlsi-2730	196	4	26(1	26(1	NUM
ajlsi-2730	196	5	)	)	PUNCT
ajlsi-2730	196	6	,	,	PUNCT
ajlsi-2730	196	7	1	1	NUM
ajlsi-2730	196	8	-	-	SYM
ajlsi-2730	196	9	15	15	NUM
ajlsi-2730	196	10	.	.	PUNCT
ajlsi-2730	197	1	gulasi	gulasi	NOUN
ajlsi-2730	197	2	,	,	PUNCT
ajlsi-2730	197	3	s.	s.	PROPN
ajlsi-2730	197	4	(	(	PUNCT
ajlsi-2730	197	5	2016	2016	NUM
ajlsi-2730	197	6	)	)	PUNCT
ajlsi-2730	197	7	.	.	PUNCT
ajlsi-2730	198	1	congenital	congenital	ADJ
ajlsi-2730	198	2	ichthyosis	ichthyosis	NOUN
ajlsi-2730	198	3	:	:	PUNCT
ajlsi-2730	198	4	a	a	DET
ajlsi-2730	198	5	case	case	NOUN
ajlsi-2730	198	6	treated	treat	VERB
ajlsi-2730	198	7	successfully	successfully	ADV
ajlsi-2730	198	8	with	with	ADP
ajlsi-2730	198	9	acitretin	acitretin	PROPN
ajlsi-2730	198	10	.	.	PUNCT
ajlsi-2730	199	1	iranian	iranian	ADJ
ajlsi-2730	199	2	journal	journal	PROPN
ajlsi-2730	199	3	of	of	ADP
ajlsi-2730	199	4	pediatrics	pediatric	NOUN
ajlsi-2730	199	5	,	,	PUNCT
ajlsi-2730	199	6	26(5	26(5	NUM
ajlsi-2730	199	7	)	)	PUNCT
ajlsi-2730	199	8	.	.	PUNCT
ajlsi-2730	200	1	pa	pa	PROPN
ajlsi-2730	200	2	ge	ge	PROPN
ajlsi-2730	200	3	74	74	NUM
ajlsi-2730	200	4	https://journals.e-palli.com/home/index.php/ajlsi	https://journals.e-palli.com/home/index.php/ajlsi	PROPN
ajlsi-2730	200	5	am	am	NOUN
ajlsi-2730	200	6	.	.	PUNCT
ajlsi-2730	201	1	j.	j.	PROPN
ajlsi-2730	201	2	life	life	PROPN
ajlsi-2730	201	3	sci	sci	PROPN
ajlsi-2730	201	4	.	.	PUNCT
ajlsi-2730	201	5	innov	innov	PROPN
ajlsi-2730	201	6	.	.	PUNCT
ajlsi-2730	202	1	3(1	3(1	NUM
ajlsi-2730	202	2	)	)	PUNCT
ajlsi-2730	202	3	69	69	NUM
ajlsi-2730	202	4	-	-	SYM
ajlsi-2730	202	5	74	74	NUM
ajlsi-2730	202	6	,	,	PUNCT
ajlsi-2730	202	7	2024	2024	NUM
ajlsi-2730	202	8	gutiérrez	gutiérrez	NOUN
ajlsi-2730	202	9	-	-	PUNCT
ajlsi-2730	202	10	cerrajero	cerrajero	NOUN
ajlsi-2730	202	11	,	,	PUNCT
ajlsi-2730	202	12	c.	c.	PROPN
ajlsi-2730	202	13	,	,	PUNCT
ajlsi-2730	202	14	sprecher	sprecher	PROPN
ajlsi-2730	202	15	,	,	PUNCT
ajlsi-2730	202	16	e.	e.	PROPN
ajlsi-2730	202	17	,	,	PUNCT
ajlsi-2730	202	18	paller	paller	NOUN
ajlsi-2730	202	19	,	,	PUNCT
ajlsi-2730	202	20	a.	a.	PROPN
ajlsi-2730	202	21	s.	s.	PROPN
ajlsi-2730	202	22	,	,	PUNCT
ajlsi-2730	202	23	akiyama	akiyama	PROPN
ajlsi-2730	202	24	,	,	PUNCT
ajlsi-2730	202	25	m.	m.	NOUN
ajlsi-2730	202	26	,	,	PUNCT
ajlsi-2730	202	27	mazereeuw	mazereeuw	PROPN
ajlsi-2730	202	28	-	-	PUNCT
ajlsi-2730	202	29	hautier	hautier	NOUN
ajlsi-2730	202	30	,	,	PUNCT
ajlsi-2730	202	31	j.	j.	PROPN
ajlsi-2730	202	32	,	,	PUNCT
ajlsi-2730	202	33	hernándezmartín	hernándezmartín	NOUN
ajlsi-2730	202	34	,	,	PUNCT
ajlsi-2730	202	35	a.	a.	PROPN
ajlsi-2730	202	36	,	,	PUNCT
ajlsi-2730	202	37	&	&	CCONJ
ajlsi-2730	202	38	gonzález	gonzález	PROPN
ajlsi-2730	202	39	-	-	PUNCT
ajlsi-2730	202	40	sarmiento	sarmiento	PROPN
ajlsi-2730	202	41	,	,	PUNCT
ajlsi-2730	202	42	r.	r.	PROPN
ajlsi-2730	202	43	(	(	PUNCT
ajlsi-2730	202	44	2023	2023	NUM
ajlsi-2730	202	45	)	)	PUNCT
ajlsi-2730	202	46	.	.	PUNCT
ajlsi-2730	203	1	ichthyosis	ichthyosis	NOUN
ajlsi-2730	203	2	.	.	PUNCT
ajlsi-2730	204	1	nature	nature	NOUN
ajlsi-2730	204	2	reviews	review	NOUN
ajlsi-2730	204	3	disease	disease	NOUN
ajlsi-2730	204	4	primers	primer	NOUN
ajlsi-2730	204	5	,	,	PUNCT
ajlsi-2730	204	6	9(1	9(1	NUM
ajlsi-2730	204	7	)	)	PUNCT
ajlsi-2730	204	8	,	,	PUNCT
ajlsi-2730	204	9	2	2	X
ajlsi-2730	204	10	.	.	X
ajlsi-2730	204	11	hernández	hernández	PROPN
ajlsi-2730	204	12	-	-	PUNCT
ajlsi-2730	204	13	martin	martin	PROPN
ajlsi-2730	204	14	,	,	PUNCT
ajlsi-2730	204	15	a.	a.	NOUN
ajlsi-2730	204	16	,	,	PUNCT
ajlsi-2730	204	17	aranegui	aranegui	NOUN
ajlsi-2730	204	18	,	,	PUNCT
ajlsi-2730	204	19	b.	b.	PROPN
ajlsi-2730	204	20	,	,	PUNCT
ajlsi-2730	204	21	martin	martin	PROPN
ajlsi-2730	204	22	-	-	PUNCT
ajlsi-2730	204	23	santiago	santiago	PROPN
ajlsi-2730	204	24	,	,	PUNCT
ajlsi-2730	204	25	a.	a.	PROPN
ajlsi-2730	204	26	,	,	PUNCT
ajlsi-2730	204	27	&	&	CCONJ
ajlsi-2730	204	28	garcia	garcia	PROPN
ajlsi-2730	204	29	-	-	PUNCT
ajlsi-2730	204	30	doval	doval	PROPN
ajlsi-2730	204	31	,	,	PUNCT
ajlsi-2730	204	32	i.	i.	PROPN
ajlsi-2730	204	33	(	(	PUNCT
ajlsi-2730	204	34	2013	2013	NUM
ajlsi-2730	204	35	)	)	PUNCT
ajlsi-2730	204	36	.	.	PUNCT
ajlsi-2730	205	1	a	a	DET
ajlsi-2730	205	2	systematic	systematic	ADJ
ajlsi-2730	205	3	review	review	NOUN
ajlsi-2730	205	4	of	of	ADP
ajlsi-2730	205	5	clinical	clinical	ADJ
ajlsi-2730	205	6	trials	trial	NOUN
ajlsi-2730	205	7	of	of	ADP
ajlsi-2730	205	8	treatments	treatment	NOUN
ajlsi-2730	205	9	for	for	ADP
ajlsi-2730	205	10	the	the	DET
ajlsi-2730	205	11	congenital	congenital	ADJ
ajlsi-2730	205	12	ichthyoses	ichthyose	NOUN
ajlsi-2730	205	13	,	,	PUNCT
ajlsi-2730	205	14	excluding	exclude	VERB
ajlsi-2730	205	15	ichthyosis	ichthyosis	NOUN
ajlsi-2730	205	16	vulgaris	vulgaris	NOUN
ajlsi-2730	205	17	.	.	PUNCT
ajlsi-2730	206	1	journal	journal	NOUN
ajlsi-2730	206	2	of	of	ADP
ajlsi-2730	206	3	the	the	DET
ajlsi-2730	206	4	american	american	PROPN
ajlsi-2730	206	5	academy	academy	PROPN
ajlsi-2730	206	6	of	of	ADP
ajlsi-2730	206	7	dermatology	dermatology	NOUN
ajlsi-2730	206	8	,	,	PUNCT
ajlsi-2730	206	9	69(4	69(4	NOUN
ajlsi-2730	206	10	)	)	PUNCT
ajlsi-2730	206	11	,	,	PUNCT
ajlsi-2730	206	12	544	544	NUM
ajlsi-2730	206	13	-	-	SYM
ajlsi-2730	206	14	549	549	NUM
ajlsi-2730	206	15	.	.	PUNCT
ajlsi-2730	207	1	e548	e548	PROPN
ajlsi-2730	207	2	.	.	PUNCT
ajlsi-2730	208	1	huangfu	huangfu	PROPN
ajlsi-2730	208	2	,	,	PUNCT
ajlsi-2730	208	3	l.	l.	PROPN
ajlsi-2730	208	4	,	,	PUNCT
ajlsi-2730	208	5	li	li	PROPN
ajlsi-2730	208	6	,	,	PUNCT
ajlsi-2730	208	7	r.	r.	PROPN
ajlsi-2730	208	8	,	,	PUNCT
ajlsi-2730	208	9	huang	huang	PROPN
ajlsi-2730	208	10	,	,	PUNCT
ajlsi-2730	208	11	y.	y.	PROPN
ajlsi-2730	208	12	,	,	PUNCT
ajlsi-2730	208	13	&	&	CCONJ
ajlsi-2730	208	14	wang	wang	PROPN
ajlsi-2730	208	15	,	,	PUNCT
ajlsi-2730	208	16	s.	s.	PROPN
ajlsi-2730	208	17	(	(	PUNCT
ajlsi-2730	208	18	2023	2023	NUM
ajlsi-2730	208	19	)	)	PUNCT
ajlsi-2730	208	20	.	.	PUNCT
ajlsi-2730	209	1	the	the	DET
ajlsi-2730	209	2	il17	il17	PROPN
ajlsi-2730	209	3	family	family	NOUN
ajlsi-2730	209	4	in	in	ADP
ajlsi-2730	209	5	diseases	disease	NOUN
ajlsi-2730	209	6	:	:	PUNCT
ajlsi-2730	209	7	from	from	ADP
ajlsi-2730	209	8	bench	bench	NOUN
ajlsi-2730	209	9	to	to	ADP
ajlsi-2730	209	10	bedside	bedside	NOUN
ajlsi-2730	209	11	.	.	PUNCT
ajlsi-2730	210	1	signal	signal	ADJ
ajlsi-2730	210	2	transduction	transduction	NOUN
ajlsi-2730	210	3	and	and	CCONJ
ajlsi-2730	210	4	targeted	target	VERB
ajlsi-2730	210	5	therapy	therapy	NOUN
ajlsi-2730	210	6	,	,	PUNCT
ajlsi-2730	210	7	8(1	8(1	NOUN
ajlsi-2730	210	8	)	)	PUNCT
ajlsi-2730	210	9	,	,	PUNCT
ajlsi-2730	210	10	402	402	X
ajlsi-2730	210	11	.	.	PUNCT
ajlsi-2730	211	1	joosten	joosten	PROPN
ajlsi-2730	211	2	,	,	PUNCT
ajlsi-2730	211	3	m.	m.	NOUN
ajlsi-2730	211	4	,	,	PUNCT
ajlsi-2730	211	5	clabbers	clabber	NOUN
ajlsi-2730	211	6	,	,	PUNCT
ajlsi-2730	211	7	j.	j.	PROPN
ajlsi-2730	211	8	,	,	PUNCT
ajlsi-2730	211	9	jonca	jonca	NOUN
ajlsi-2730	211	10	,	,	PUNCT
ajlsi-2730	211	11	n.	n.	NOUN
ajlsi-2730	211	12	,	,	PUNCT
ajlsi-2730	211	13	mazereeuw	mazereeuw	PROPN
ajlsi-2730	211	14	-	-	PUNCT
ajlsi-2730	211	15	hautier	hautier	NOUN
ajlsi-2730	211	16	,	,	PUNCT
ajlsi-2730	211	17	j.	j.	PROPN
ajlsi-2730	211	18	,	,	PUNCT
ajlsi-2730	211	19	&	&	CCONJ
ajlsi-2730	211	20	gostyński	gostyński	NOUN
ajlsi-2730	211	21	,	,	PUNCT
ajlsi-2730	211	22	a.	a.	NOUN
ajlsi-2730	211	23	(	(	PUNCT
ajlsi-2730	211	24	2022	2022	NUM
ajlsi-2730	211	25	)	)	PUNCT
ajlsi-2730	211	26	.	.	PUNCT
ajlsi-2730	212	1	new	new	ADJ
ajlsi-2730	212	2	developments	development	NOUN
ajlsi-2730	212	3	in	in	ADP
ajlsi-2730	212	4	the	the	DET
ajlsi-2730	212	5	molecular	molecular	ADJ
ajlsi-2730	212	6	treatment	treatment	NOUN
ajlsi-2730	212	7	of	of	ADP
ajlsi-2730	212	8	ichthyosis	ichthyosis	NOUN
ajlsi-2730	212	9	:	:	PUNCT
ajlsi-2730	212	10	review	review	NOUN
ajlsi-2730	212	11	of	of	ADP
ajlsi-2730	212	12	the	the	DET
ajlsi-2730	212	13	literature	literature	NOUN
ajlsi-2730	212	14	.	.	PUNCT
ajlsi-2730	213	1	orphanet	orphanet	PROPN
ajlsi-2730	213	2	journal	journal	PROPN
ajlsi-2730	213	3	of	of	ADP
ajlsi-2730	213	4	rare	rare	ADJ
ajlsi-2730	213	5	diseases	disease	NOUN
ajlsi-2730	213	6	,	,	PUNCT
ajlsi-2730	213	7	17(1	17(1	NUM
ajlsi-2730	213	8	)	)	PUNCT
ajlsi-2730	213	9	,	,	PUNCT
ajlsi-2730	213	10	269	269	NUM
ajlsi-2730	213	11	.	.	PUNCT
ajlsi-2730	214	1	kim	kim	PROPN
ajlsi-2730	214	2	,	,	PUNCT
ajlsi-2730	214	3	m.	m.	NOUN
ajlsi-2730	214	4	,	,	PUNCT
ajlsi-2730	214	5	mikhaylov	mikhaylov	PROPN
ajlsi-2730	214	6	,	,	PUNCT
ajlsi-2730	214	7	d.	d.	PROPN
ajlsi-2730	214	8	,	,	PUNCT
ajlsi-2730	214	9	rangel	rangel	PROPN
ajlsi-2730	214	10	,	,	PUNCT
ajlsi-2730	214	11	s.	s.	PROPN
ajlsi-2730	214	12	m.	m.	PROPN
ajlsi-2730	214	13	,	,	PUNCT
ajlsi-2730	214	14	pavel	pavel	PROPN
ajlsi-2730	214	15	,	,	PUNCT
ajlsi-2730	214	16	a.	a.	PROPN
ajlsi-2730	214	17	b.	b.	PROPN
ajlsi-2730	214	18	,	,	PUNCT
ajlsi-2730	214	19	he	he	PRON
ajlsi-2730	214	20	,	,	PUNCT
ajlsi-2730	214	21	h.	h.	PROPN
ajlsi-2730	214	22	,	,	PUNCT
ajlsi-2730	214	23	renert	renert	NOUN
ajlsi-2730	214	24	-	-	PUNCT
ajlsi-2730	214	25	yuval	yuval	NOUN
ajlsi-2730	214	26	,	,	PUNCT
ajlsi-2730	214	27	y.	y.	PROPN
ajlsi-2730	214	28	,	,	PUNCT
ajlsi-2730	214	29	del	del	PROPN
ajlsi-2730	214	30	duca	duca	PROPN
ajlsi-2730	214	31	,	,	PUNCT
ajlsi-2730	214	32	e.	e.	PROPN
ajlsi-2730	214	33	,	,	PUNCT
ajlsi-2730	214	34	malik	malik	PROPN
ajlsi-2730	214	35	,	,	PUNCT
ajlsi-2730	214	36	k.	k.	PROPN
ajlsi-2730	214	37	,	,	PUNCT
ajlsi-2730	214	38	huynh	huynh	PROPN
ajlsi-2730	214	39	,	,	PUNCT
ajlsi-2730	214	40	t.	t.	PROPN
ajlsi-2730	214	41	,	,	PUNCT
ajlsi-2730	214	42	&	&	CCONJ
ajlsi-2730	214	43	ibler	ibler	NOUN
ajlsi-2730	214	44	,	,	PUNCT
ajlsi-2730	214	45	e.	e.	PROPN
ajlsi-2730	214	46	(	(	PUNCT
ajlsi-2730	214	47	2022	2022	NUM
ajlsi-2730	214	48	)	)	PUNCT
ajlsi-2730	214	49	.	.	PUNCT
ajlsi-2730	215	1	transcriptomic	transcriptomic	ADJ
ajlsi-2730	215	2	analysis	analysis	NOUN
ajlsi-2730	215	3	of	of	ADP
ajlsi-2730	215	4	the	the	DET
ajlsi-2730	215	5	major	major	ADJ
ajlsi-2730	215	6	orphan	orphan	NOUN
ajlsi-2730	215	7	ichthyosis	ichthyosis	NOUN
ajlsi-2730	215	8	subtypes	subtype	NOUN
ajlsi-2730	215	9	reveals	reveal	VERB
ajlsi-2730	215	10	shared	share	VERB
ajlsi-2730	215	11	immune	immune	ADJ
ajlsi-2730	215	12	and	and	CCONJ
ajlsi-2730	215	13	barrier	barrier	NOUN
ajlsi-2730	215	14	signatures	signature	NOUN
ajlsi-2730	215	15	.	.	PUNCT
ajlsi-2730	216	1	journal	journal	NOUN
ajlsi-2730	216	2	of	of	ADP
ajlsi-2730	216	3	investigative	investigative	ADJ
ajlsi-2730	216	4	dermatology	dermatology	NOUN
ajlsi-2730	216	5	,	,	PUNCT
ajlsi-2730	216	6	142(9	142(9	NUM
ajlsi-2730	216	7	)	)	PUNCT
ajlsi-2730	216	8	,	,	PUNCT
ajlsi-2730	216	9	2363	2363	NUM
ajlsi-2730	216	10	-	-	SYM
ajlsi-2730	216	11	2374	2374	NUM
ajlsi-2730	216	12	.	.	PUNCT
ajlsi-2730	217	1	e2318	e2318	NOUN
ajlsi-2730	217	2	.	.	PUNCT
ajlsi-2730	218	1	lilly	lilly	PROPN
ajlsi-2730	218	2	,	,	PUNCT
ajlsi-2730	218	3	e.	e.	PROPN
ajlsi-2730	218	4	,	,	PUNCT
ajlsi-2730	218	5	&	&	CCONJ
ajlsi-2730	218	6	bunick	bunick	PROPN
ajlsi-2730	218	7	,	,	PUNCT
ajlsi-2730	218	8	c.	c.	PROPN
ajlsi-2730	218	9	g.	g.	PROPN
ajlsi-2730	218	10	(	(	PUNCT
ajlsi-2730	218	11	2023	2023	NUM
ajlsi-2730	218	12	)	)	PUNCT
ajlsi-2730	218	13	.	.	PUNCT
ajlsi-2730	219	1	congenital	congenital	ADJ
ajlsi-2730	219	2	ichthyosis	ichthyosis	NOUN
ajlsi-2730	219	3	:	:	PUNCT
ajlsi-2730	219	4	a	a	DET
ajlsi-2730	219	5	practical	practical	ADJ
ajlsi-2730	219	6	clinical	clinical	ADJ
ajlsi-2730	219	7	guide	guide	NOUN
ajlsi-2730	219	8	on	on	ADP
ajlsi-2730	219	9	current	current	ADJ
ajlsi-2730	219	10	treatments	treatment	NOUN
ajlsi-2730	219	11	and	and	CCONJ
ajlsi-2730	219	12	future	future	ADJ
ajlsi-2730	219	13	perspectives	perspective	NOUN
ajlsi-2730	219	14	.	.	PUNCT
ajlsi-2730	220	1	clinical	clinical	ADJ
ajlsi-2730	220	2	,	,	PUNCT
ajlsi-2730	220	3	cosmetic	cosmetic	ADJ
ajlsi-2730	220	4	and	and	CCONJ
ajlsi-2730	220	5	investigational	investigational	ADJ
ajlsi-2730	220	6	dermatology	dermatology	NOUN
ajlsi-2730	220	7	,	,	PUNCT
ajlsi-2730	220	8	2473	2473	NUM
ajlsi-2730	220	9	-	-	SYM
ajlsi-2730	220	10	2479	2479	NUM
ajlsi-2730	220	11	.	.	PUNCT
ajlsi-2730	221	1	martin	martin	NOUN
ajlsi-2730	221	2	-	-	PUNCT
ajlsi-2730	221	3	garcía	garcía	ADJ
ajlsi-2730	221	4	,	,	PUNCT
ajlsi-2730	221	5	c.	c.	PROPN
ajlsi-2730	221	6	,	,	PUNCT
ajlsi-2730	221	7	godoy	godoy	PROPN
ajlsi-2730	221	8	,	,	PUNCT
ajlsi-2730	221	9	e.	e.	PROPN
ajlsi-2730	221	10	,	,	PUNCT
ajlsi-2730	221	11	cabrera	cabrera	PROPN
ajlsi-2730	221	12	,	,	PUNCT
ajlsi-2730	221	13	a.	a.	PROPN
ajlsi-2730	221	14	,	,	PUNCT
ajlsi-2730	221	15	cañueto	cañueto	PROPN
ajlsi-2730	221	16	,	,	PUNCT
ajlsi-2730	221	17	j.	j.	PROPN
ajlsi-2730	221	18	,	,	PUNCT
ajlsi-2730	221	19	muñoz	muñoz	PROPN
ajlsi-2730	221	20	-	-	PUNCT
ajlsi-2730	221	21	bellido	bellido	PROPN
ajlsi-2730	221	22	,	,	PUNCT
ajlsi-2730	221	23	f.	f.	PROPN
ajlsi-2730	221	24	j.	j.	PROPN
ajlsi-2730	221	25	,	,	PUNCT
ajlsi-2730	221	26	perez	perez	PROPN
ajlsi-2730	221	27	-	-	PUNCT
ajlsi-2730	221	28	pazos	pazos	PROPN
ajlsi-2730	221	29	,	,	PUNCT
ajlsi-2730	221	30	j.	j.	PROPN
ajlsi-2730	221	31	,	,	PUNCT
ajlsi-2730	221	32	&	&	CCONJ
ajlsi-2730	221	33	dávila	dávila	PROPN
ajlsi-2730	221	34	,	,	PUNCT
ajlsi-2730	221	35	i.	i.	NOUN
ajlsi-2730	221	36	(	(	PUNCT
ajlsi-2730	221	37	2023	2023	NUM
ajlsi-2730	221	38	)	)	PUNCT
ajlsi-2730	221	39	.	.	PUNCT
ajlsi-2730	222	1	report	report	NOUN
ajlsi-2730	222	2	of	of	ADP
ajlsi-2730	222	3	two	two	NUM
ajlsi-2730	222	4	sisters	sister	NOUN
ajlsi-2730	222	5	with	with	ADP
ajlsi-2730	222	6	netherton	netherton	PROPN
ajlsi-2730	222	7	syndrome	syndrome	PROPN
ajlsi-2730	222	8	successfully	successfully	ADV
ajlsi-2730	222	9	treated	treat	VERB
ajlsi-2730	222	10	with	with	ADP
ajlsi-2730	222	11	dupilumab	dupilumab	NOUN
ajlsi-2730	222	12	and	and	CCONJ
ajlsi-2730	222	13	review	review	NOUN
ajlsi-2730	222	14	of	of	ADP
ajlsi-2730	222	15	the	the	DET
ajlsi-2730	222	16	literature	literature	NOUN
ajlsi-2730	222	17	.	.	PUNCT
ajlsi-2730	223	1	international	international	ADJ
ajlsi-2730	223	2	journal	journal	PROPN
ajlsi-2730	223	3	of	of	ADP
ajlsi-2730	223	4	immunopathology	immunopathology	NOUN
ajlsi-2730	223	5	and	and	CCONJ
ajlsi-2730	223	6	pharmacology	pharmacology	NOUN
ajlsi-2730	223	7	,	,	PUNCT
ajlsi-2730	223	8	37	37	NUM
ajlsi-2730	223	9	,	,	PUNCT
ajlsi-2730	223	10	03946320231172881	03946320231172881	NUM
ajlsi-2730	223	11	.	.	PUNCT
ajlsi-2730	224	1	narbutt	narbutt	PROPN
ajlsi-2730	224	2	,	,	PUNCT
ajlsi-2730	224	3	j.	j.	PROPN
ajlsi-2730	224	4	,	,	PUNCT
ajlsi-2730	224	5	niedźwiedź	niedźwiedź	PROPN
ajlsi-2730	224	6	,	,	PUNCT
ajlsi-2730	224	7	m.	m.	NOUN
ajlsi-2730	224	8	,	,	PUNCT
ajlsi-2730	224	9	lesiak	lesiak	PROPN
ajlsi-2730	224	10	,	,	PUNCT
ajlsi-2730	224	11	a.	a.	PROPN
ajlsi-2730	224	12	,	,	PUNCT
ajlsi-2730	224	13	ceryn	ceryn	PROPN
ajlsi-2730	224	14	,	,	PUNCT
ajlsi-2730	224	15	j.	j.	PROPN
ajlsi-2730	224	16	,	,	PUNCT
ajlsi-2730	224	17	&	&	CCONJ
ajlsi-2730	224	18	skibińska	skibińska	PROPN
ajlsi-2730	224	19	,	,	PUNCT
ajlsi-2730	224	20	m.	m.	NOUN
ajlsi-2730	224	21	(	(	PUNCT
ajlsi-2730	224	22	2023	2023	NUM
ajlsi-2730	224	23	)	)	PUNCT
ajlsi-2730	224	24	.	.	PUNCT
ajlsi-2730	225	1	secukinumab	secukinumab	NOUN
ajlsi-2730	225	2	for	for	ADP
ajlsi-2730	225	3	the	the	DET
ajlsi-2730	225	4	treatment	treatment	NOUN
ajlsi-2730	225	5	of	of	ADP
ajlsi-2730	225	6	psoriasis	psoriasis	NOUN
ajlsi-2730	225	7	in	in	ADP
ajlsi-2730	225	8	pediatrics	pediatric	NOUN
ajlsi-2730	225	9	:	:	PUNCT
ajlsi-2730	225	10	patient	patient	ADJ
ajlsi-2730	225	11	selection	selection	NOUN
ajlsi-2730	225	12	and	and	CCONJ
ajlsi-2730	225	13	acceptability	acceptability	NOUN
ajlsi-2730	225	14	.	.	PUNCT
ajlsi-2730	226	1	patient	patient	ADJ
ajlsi-2730	226	2	preference	preference	NOUN
ajlsi-2730	226	3	and	and	CCONJ
ajlsi-2730	226	4	adherence	adherence	NOUN
ajlsi-2730	226	5	,	,	PUNCT
ajlsi-2730	226	6	421	421	NUM
ajlsi-2730	226	7	-	-	SYM
ajlsi-2730	226	8	431	431	NUM
ajlsi-2730	226	9	.	.	PUNCT
ajlsi-2730	227	1	olbrich	olbrich	PROPN
ajlsi-2730	227	2	,	,	PUNCT
ajlsi-2730	227	3	h.	h.	PROPN
ajlsi-2730	227	4	,	,	PUNCT
ajlsi-2730	227	5	sadik	sadik	PROPN
ajlsi-2730	227	6	,	,	PUNCT
ajlsi-2730	227	7	c.	c.	PROPN
ajlsi-2730	227	8	d.	d.	PROPN
ajlsi-2730	227	9	,	,	PUNCT
ajlsi-2730	227	10	ludwig	ludwig	PROPN
ajlsi-2730	227	11	,	,	PUNCT
ajlsi-2730	227	12	r.	r.	PROPN
ajlsi-2730	227	13	j.	j.	PROPN
ajlsi-2730	227	14	,	,	PUNCT
ajlsi-2730	227	15	thaçi	thaçi	PROPN
ajlsi-2730	227	16	,	,	PUNCT
ajlsi-2730	227	17	d.	d.	PROPN
ajlsi-2730	227	18	,	,	PUNCT
ajlsi-2730	227	19	&	&	CCONJ
ajlsi-2730	227	20	boch	boch	PROPN
ajlsi-2730	227	21	,	,	PUNCT
ajlsi-2730	227	22	k.	k.	PROPN
ajlsi-2730	227	23	(	(	PUNCT
ajlsi-2730	227	24	2023	2023	NUM
ajlsi-2730	227	25	)	)	PUNCT
ajlsi-2730	227	26	.	.	PUNCT
ajlsi-2730	228	1	dupilumab	dupilumab	NOUN
ajlsi-2730	228	2	in	in	ADP
ajlsi-2730	228	3	inflammatory	inflammatory	ADJ
ajlsi-2730	228	4	skin	skin	NOUN
ajlsi-2730	228	5	diseases	disease	NOUN
ajlsi-2730	228	6	:	:	PUNCT
ajlsi-2730	228	7	a	a	DET
ajlsi-2730	228	8	systematic	systematic	ADJ
ajlsi-2730	228	9	review	review	NOUN
ajlsi-2730	228	10	.	.	PUNCT
ajlsi-2730	229	1	biomolecules	biomolecule	NOUN
ajlsi-2730	229	2	,	,	PUNCT
ajlsi-2730	229	3	13(4	13(4	NUM
ajlsi-2730	229	4	)	)	PUNCT
ajlsi-2730	229	5	,	,	PUNCT
ajlsi-2730	229	6	634	634	NUM
ajlsi-2730	229	7	.	.	PUNCT
ajlsi-2730	229	8	paller	paller	NOUN
ajlsi-2730	229	9	,	,	PUNCT
ajlsi-2730	229	10	a.	a.	PROPN
ajlsi-2730	229	11	s.	s.	PROPN
ajlsi-2730	229	12	(	(	PUNCT
ajlsi-2730	229	13	2019	2019	NUM
ajlsi-2730	229	14	)	)	PUNCT
ajlsi-2730	229	15	.	.	PUNCT
ajlsi-2730	230	1	profiling	profile	VERB
ajlsi-2730	230	2	immune	immune	ADJ
ajlsi-2730	230	3	expression	expression	NOUN
ajlsi-2730	230	4	to	to	PART
ajlsi-2730	230	5	consider	consider	VERB
ajlsi-2730	230	6	repurposing	repurpose	VERB
ajlsi-2730	230	7	therapeutics	therapeutic	NOUN
ajlsi-2730	230	8	for	for	ADP
ajlsi-2730	230	9	the	the	DET
ajlsi-2730	230	10	ichthyoses	ichthyose	NOUN
ajlsi-2730	230	11	.	.	PUNCT
ajlsi-2730	231	1	journal	journal	NOUN
ajlsi-2730	231	2	of	of	ADP
ajlsi-2730	231	3	investigative	investigative	ADJ
ajlsi-2730	231	4	dermatology	dermatology	NOUN
ajlsi-2730	231	5	,	,	PUNCT
ajlsi-2730	231	6	139(3	139(3	NUM
ajlsi-2730	231	7	)	)	PUNCT
ajlsi-2730	231	8	,	,	PUNCT
ajlsi-2730	231	9	535	535	NUM
ajlsi-2730	231	10	-	-	SYM
ajlsi-2730	231	11	540	540	NUM
ajlsi-2730	231	12	.	.	PUNCT
ajlsi-2730	232	1	paller	paller	NOUN
ajlsi-2730	232	2	,	,	PUNCT
ajlsi-2730	232	3	a.	a.	PROPN
ajlsi-2730	232	4	s.	s.	PROPN
ajlsi-2730	232	5	,	,	PUNCT
ajlsi-2730	232	6	renert	renert	NOUN
ajlsi-2730	232	7	-	-	PUNCT
ajlsi-2730	232	8	yuval	yuval	NOUN
ajlsi-2730	232	9	,	,	PUNCT
ajlsi-2730	232	10	y.	y.	NOUN
ajlsi-2730	232	11	,	,	PUNCT
ajlsi-2730	232	12	suprun	suprun	ADJ
ajlsi-2730	232	13	,	,	PUNCT
ajlsi-2730	232	14	m.	m.	NOUN
ajlsi-2730	232	15	,	,	PUNCT
ajlsi-2730	232	16	esaki	esaki	PROPN
ajlsi-2730	232	17	,	,	PUNCT
ajlsi-2730	232	18	h.	h.	PROPN
ajlsi-2730	232	19	,	,	PUNCT
ajlsi-2730	232	20	oliva	oliva	PROPN
ajlsi-2730	232	21	,	,	PUNCT
ajlsi-2730	232	22	m.	m.	NOUN
ajlsi-2730	232	23	,	,	PUNCT
ajlsi-2730	232	24	huynh	huynh	PROPN
ajlsi-2730	232	25	,	,	PUNCT
ajlsi-2730	232	26	t.	t.	PROPN
ajlsi-2730	232	27	n.	n.	PROPN
ajlsi-2730	232	28	,	,	PUNCT
ajlsi-2730	232	29	ungar	ungar	NOUN
ajlsi-2730	232	30	,	,	PUNCT
ajlsi-2730	232	31	b.	b.	PROPN
ajlsi-2730	232	32	,	,	PUNCT
ajlsi-2730	232	33	kunjravia	kunjravia	PROPN
ajlsi-2730	232	34	,	,	PUNCT
ajlsi-2730	232	35	n.	n.	PROPN
ajlsi-2730	232	36	,	,	PUNCT
ajlsi-2730	232	37	friedland	friedland	PROPN
ajlsi-2730	232	38	,	,	PUNCT
ajlsi-2730	232	39	r.	r.	PROPN
ajlsi-2730	232	40	,	,	PUNCT
ajlsi-2730	232	41	&	&	CCONJ
ajlsi-2730	232	42	peng	peng	PROPN
ajlsi-2730	232	43	,	,	PUNCT
ajlsi-2730	232	44	x.	x.	NOUN
ajlsi-2730	232	45	(	(	PUNCT
ajlsi-2730	232	46	2017	2017	NUM
ajlsi-2730	232	47	)	)	PUNCT
ajlsi-2730	232	48	.	.	PUNCT
ajlsi-2730	233	1	an	an	DET
ajlsi-2730	233	2	il-17	il-17	ADV
ajlsi-2730	233	3	–	–	PUNCT
ajlsi-2730	233	4	dominant	dominant	ADJ
ajlsi-2730	233	5	immune	immune	ADJ
ajlsi-2730	233	6	profile	profile	NOUN
ajlsi-2730	233	7	is	be	AUX
ajlsi-2730	233	8	shared	share	VERB
ajlsi-2730	233	9	across	across	ADP
ajlsi-2730	233	10	the	the	DET
ajlsi-2730	233	11	major	major	ADJ
ajlsi-2730	233	12	orphan	orphan	NOUN
ajlsi-2730	233	13	forms	form	NOUN
ajlsi-2730	233	14	of	of	ADP
ajlsi-2730	233	15	ichthyosis	ichthyosis	NOUN
ajlsi-2730	233	16	.	.	PUNCT
ajlsi-2730	234	1	journal	journal	NOUN
ajlsi-2730	234	2	of	of	ADP
ajlsi-2730	234	3	allergy	allergy	PROPN
ajlsi-2730	234	4	and	and	CCONJ
ajlsi-2730	234	5	clinical	clinical	ADJ
ajlsi-2730	234	6	immunology	immunology	NOUN
ajlsi-2730	234	7	,	,	PUNCT
ajlsi-2730	234	8	139(1	139(1	NUM
ajlsi-2730	234	9	)	)	PUNCT
ajlsi-2730	234	10	,	,	PUNCT
ajlsi-2730	234	11	152	152	NUM
ajlsi-2730	234	12	-	-	SYM
ajlsi-2730	234	13	165	165	NUM
ajlsi-2730	234	14	.	.	PUNCT
ajlsi-2730	235	1	palmer	palmer	PROPN
ajlsi-2730	235	2	,	,	PUNCT
ajlsi-2730	235	3	v.	v.	PROPN
ajlsi-2730	235	4	,	,	PUNCT
ajlsi-2730	235	5	&	&	CCONJ
ajlsi-2730	235	6	dunwell	dunwell	PROPN
ajlsi-2730	235	7	,	,	PUNCT
ajlsi-2730	235	8	p.	p.	NOUN
ajlsi-2730	235	9	(	(	PUNCT
ajlsi-2730	235	10	2022	2022	NUM
ajlsi-2730	235	11	)	)	PUNCT
ajlsi-2730	235	12	.	.	PUNCT
ajlsi-2730	236	1	a	a	DET
ajlsi-2730	236	2	case	case	NOUN
ajlsi-2730	236	3	of	of	ADP
ajlsi-2730	236	4	ichthyosis	ichthyosis	NOUN
ajlsi-2730	236	5	vulgaris	vulgaris	NOUN
ajlsi-2730	236	6	and	and	CCONJ
ajlsi-2730	236	7	the	the	DET
ajlsi-2730	236	8	use	use	NOUN
ajlsi-2730	236	9	of	of	ADP
ajlsi-2730	236	10	70	70	NUM
ajlsi-2730	236	11	%	%	NOUN
ajlsi-2730	236	12	glycolic	glycolic	NOUN
ajlsi-2730	236	13	acid	acid	NOUN
ajlsi-2730	236	14	chemical	chemical	NOUN
ajlsi-2730	236	15	peels	peel	NOUN
ajlsi-2730	236	16	for	for	ADP
ajlsi-2730	236	17	management	management	NOUN
ajlsi-2730	236	18	.	.	PUNCT
ajlsi-2730	237	1	cureus	cureus	NOUN
ajlsi-2730	237	2	,	,	PUNCT
ajlsi-2730	237	3	14(9	14(9	NUM
ajlsi-2730	237	4	)	)	PUNCT
ajlsi-2730	237	5	.	.	PUNCT
ajlsi-2730	238	1	peña	peña	PROPN
ajlsi-2730	238	2	-	-	PUNCT
ajlsi-2730	238	3	corona	corona	PROPN
ajlsi-2730	238	4	,	,	PUNCT
ajlsi-2730	238	5	s.	s.	PROPN
ajlsi-2730	238	6	i.	i.	PROPN
ajlsi-2730	238	7	,	,	PUNCT
ajlsi-2730	238	8	echeverria	echeverria	PROPN
ajlsi-2730	238	9	,	,	PUNCT
ajlsi-2730	238	10	m.	m.	PROPN
ajlsi-2730	238	11	d.	d.	PROPN
ajlsi-2730	238	12	l.	l.	PROPN
ajlsi-2730	238	13	d.	d.	PROPN
ajlsi-2730	238	14	c.	c.	PROPN
ajlsi-2730	238	15	,	,	PUNCT
ajlsi-2730	238	16	cortés	cortés	PROPN
ajlsi-2730	238	17	,	,	PUNCT
ajlsi-2730	238	18	h.	h.	PROPN
ajlsi-2730	238	19	,	,	PUNCT
ajlsi-2730	238	20	carmen	carman	NOUN
ajlsi-2730	238	21	,	,	PUNCT
ajlsi-2730	238	22	g.-d	g.-d	PROPN
ajlsi-2730	238	23	.	.	PUNCT
ajlsi-2730	238	24	,	,	PUNCT
ajlsi-2730	238	25	&	&	CCONJ
ajlsi-2730	238	26	leyva	leyva	PROPN
ajlsi-2730	238	27	-	-	PUNCT
ajlsi-2730	238	28	gómez	gómez	NOUN
ajlsi-2730	238	29	,	,	PUNCT
ajlsi-2730	238	30	g.	g.	PROPN
ajlsi-2730	238	31	(	(	PUNCT
ajlsi-2730	238	32	2023	2023	NUM
ajlsi-2730	238	33	)	)	PUNCT
ajlsi-2730	238	34	.	.	PUNCT
ajlsi-2730	239	1	advances	advance	NOUN
ajlsi-2730	239	2	in	in	ADP
ajlsi-2730	239	3	the	the	DET
ajlsi-2730	239	4	treatment	treatment	NOUN
ajlsi-2730	239	5	of	of	ADP
ajlsi-2730	239	6	autosomal	autosomal	ADJ
ajlsi-2730	239	7	recessive	recessive	ADJ
ajlsi-2730	239	8	congenital	congenital	ADJ
ajlsi-2730	239	9	ichthyosis	ichthyosis	NOUN
ajlsi-2730	239	10	,	,	PUNCT
ajlsi-2730	239	11	a	a	DET
ajlsi-2730	239	12	look	look	NOUN
ajlsi-2730	239	13	towards	towards	ADP
ajlsi-2730	239	14	the	the	DET
ajlsi-2730	239	15	repositioning	repositioning	NOUN
ajlsi-2730	239	16	of	of	ADP
ajlsi-2730	239	17	drugs	drug	NOUN
ajlsi-2730	239	18	.	.	PUNCT
ajlsi-2730	240	1	frontiers	frontier	NOUN
ajlsi-2730	240	2	in	in	ADP
ajlsi-2730	240	3	pharmacology	pharmacology	NOUN
ajlsi-2730	240	4	,	,	PUNCT
ajlsi-2730	240	5	14	14	NUM
ajlsi-2730	240	6	,	,	PUNCT
ajlsi-2730	240	7	1274248	1274248	NUM
ajlsi-2730	240	8	.	.	PUNCT
ajlsi-2730	241	1	pontello	pontello	PROPN
ajlsi-2730	241	2	,	,	PUNCT
ajlsi-2730	241	3	e.	e.	PROPN
ajlsi-2730	241	4	,	,	PUNCT
ajlsi-2730	241	5	battajon	battajon	NOUN
ajlsi-2730	241	6	,	,	PUNCT
ajlsi-2730	241	7	n.	n.	NOUN
ajlsi-2730	241	8	,	,	PUNCT
ajlsi-2730	241	9	tormena	tormena	PROPN
ajlsi-2730	241	10	,	,	PUNCT
ajlsi-2730	241	11	f.	f.	PROPN
ajlsi-2730	241	12	,	,	PUNCT
ajlsi-2730	241	13	giovannini	giovannini	PROPN
ajlsi-2730	241	14	,	,	PUNCT
ajlsi-2730	241	15	m.	m.	NOUN
ajlsi-2730	241	16	,	,	PUNCT
ajlsi-2730	241	17	buffo	buffo	PROPN
ajlsi-2730	241	18	,	,	PUNCT
ajlsi-2730	241	19	m.	m.	NOUN
ajlsi-2730	241	20	,	,	PUNCT
ajlsi-2730	241	21	mainini	mainini	ADJ
ajlsi-2730	241	22	,	,	PUNCT
ajlsi-2730	241	23	n.	n.	NOUN
ajlsi-2730	241	24	,	,	PUNCT
ajlsi-2730	241	25	visintin	visintin	PROPN
ajlsi-2730	241	26	,	,	PUNCT
ajlsi-2730	241	27	g.	g.	PROPN
ajlsi-2730	241	28	,	,	PUNCT
ajlsi-2730	241	29	favero	favero	PROPN
ajlsi-2730	241	30	,	,	PUNCT
ajlsi-2730	241	31	v.	v.	NOUN
ajlsi-2730	241	32	,	,	PUNCT
ajlsi-2730	241	33	vendramin	vendramin	NOUN
ajlsi-2730	241	34	,	,	PUNCT
ajlsi-2730	241	35	s.	s.	PROPN
ajlsi-2730	241	36	,	,	PUNCT
ajlsi-2730	241	37	&	&	CCONJ
ajlsi-2730	241	38	galeazzo	galeazzo	PROPN
ajlsi-2730	241	39	,	,	PUNCT
ajlsi-2730	241	40	b.	b.	PROPN
ajlsi-2730	241	41	(	(	PUNCT
ajlsi-2730	241	42	2020	2020	NUM
ajlsi-2730	241	43	)	)	PUNCT
ajlsi-2730	241	44	.	.	PUNCT
ajlsi-2730	242	1	congenital	congenital	ADJ
ajlsi-2730	242	2	ichthyosis	ichthyosis	NOUN
ajlsi-2730	242	3	in	in	ADP
ajlsi-2730	242	4	newborns	newborn	NOUN
ajlsi-2730	242	5	.	.	PUNCT
ajlsi-2730	243	1	a	a	DET
ajlsi-2730	243	2	case	case	NOUN
ajlsi-2730	243	3	-	-	PUNCT
ajlsi-2730	243	4	series	series	NOUN
ajlsi-2730	243	5	and	and	CCONJ
ajlsi-2730	243	6	review	review	NOUN
ajlsi-2730	243	7	of	of	ADP
ajlsi-2730	243	8	the	the	DET
ajlsi-2730	243	9	literature	literature	NOUN
ajlsi-2730	243	10	.	.	PUNCT
ajlsi-2730	244	1	european	european	PROPN
ajlsi-2730	244	2	journal	journal	PROPN
ajlsi-2730	244	3	of	of	ADP
ajlsi-2730	244	4	pediatric	pediatric	ADJ
ajlsi-2730	244	5	dermatology	dermatology	NOUN
ajlsi-2730	244	6	,	,	PUNCT
ajlsi-2730	244	7	30(2	30(2	NUM
ajlsi-2730	244	8	)	)	PUNCT
ajlsi-2730	244	9	,	,	PUNCT
ajlsi-2730	244	10	104	104	NUM
ajlsi-2730	244	11	-	-	SYM
ajlsi-2730	244	12	110	110	NUM
ajlsi-2730	244	13	.	.	PUNCT
ajlsi-2730	245	1	pontone	pontone	VERB
ajlsi-2730	245	2	,	,	PUNCT
ajlsi-2730	245	3	m.	m.	NOUN
ajlsi-2730	245	4	,	,	PUNCT
ajlsi-2730	245	5	giovannini	giovannini	PROPN
ajlsi-2730	245	6	,	,	PUNCT
ajlsi-2730	245	7	m.	m.	NOUN
ajlsi-2730	245	8	,	,	PUNCT
ajlsi-2730	245	9	filippeschi	filippeschi	PROPN
ajlsi-2730	245	10	,	,	PUNCT
ajlsi-2730	245	11	c.	c.	NOUN
ajlsi-2730	245	12	,	,	PUNCT
ajlsi-2730	245	13	oranges	orange	NOUN
ajlsi-2730	245	14	,	,	PUNCT
ajlsi-2730	245	15	t.	t.	NOUN
ajlsi-2730	245	16	,	,	PUNCT
ajlsi-2730	245	17	pedaci	pedaci	NOUN
ajlsi-2730	245	18	,	,	PUNCT
ajlsi-2730	245	19	f.	f.	PROPN
ajlsi-2730	245	20	a.	a.	PROPN
ajlsi-2730	245	21	,	,	PUNCT
ajlsi-2730	245	22	mori	mori	PROPN
ajlsi-2730	245	23	,	,	PUNCT
ajlsi-2730	245	24	f.	f.	PROPN
ajlsi-2730	245	25	,	,	PUNCT
ajlsi-2730	245	26	barni	barni	PROPN
ajlsi-2730	245	27	,	,	PUNCT
ajlsi-2730	245	28	s.	s.	PROPN
ajlsi-2730	245	29	,	,	PUNCT
ajlsi-2730	245	30	barbati	barbati	PROPN
ajlsi-2730	245	31	,	,	PUNCT
ajlsi-2730	245	32	f.	f.	PROPN
ajlsi-2730	245	33	,	,	PUNCT
ajlsi-2730	245	34	consonni	consonni	PROPN
ajlsi-2730	245	35	,	,	PUNCT
ajlsi-2730	245	36	f.	f.	PROPN
ajlsi-2730	245	37	,	,	PUNCT
ajlsi-2730	245	38	&	&	CCONJ
ajlsi-2730	245	39	indolfi	indolfi	PROPN
ajlsi-2730	245	40	,	,	PUNCT
ajlsi-2730	245	41	g.	g.	PROPN
ajlsi-2730	245	42	(	(	PUNCT
ajlsi-2730	245	43	2022	2022	NUM
ajlsi-2730	245	44	)	)	PUNCT
ajlsi-2730	245	45	.	.	PUNCT
ajlsi-2730	246	1	biological	biological	ADJ
ajlsi-2730	246	2	treatments	treatment	NOUN
ajlsi-2730	246	3	for	for	ADP
ajlsi-2730	246	4	pediatric	pediatric	ADJ
ajlsi-2730	246	5	netherton	netherton	NOUN
ajlsi-2730	246	6	syndrome	syndrome	NOUN
ajlsi-2730	246	7	.	.	PUNCT
ajlsi-2730	247	1	frontiers	frontier	NOUN
ajlsi-2730	247	2	in	in	ADP
ajlsi-2730	247	3	pediatrics	pediatric	NOUN
ajlsi-2730	247	4	,	,	PUNCT
ajlsi-2730	247	5	10	10	NUM
ajlsi-2730	247	6	,	,	PUNCT
ajlsi-2730	247	7	1074243	1074243	NUM
ajlsi-2730	247	8	.	.	PUNCT
ajlsi-2730	248	1	roda	roda	PROPN
ajlsi-2730	248	2	,	,	PUNCT
ajlsi-2730	248	3	â	â	PROPN
ajlsi-2730	248	4	.	.	PROPN
ajlsi-2730	248	5	,	,	PUNCT
ajlsi-2730	248	6	mendonça	mendonça	NOUN
ajlsi-2730	248	7	-	-	PUNCT
ajlsi-2730	248	8	sanches	sanche	NOUN
ajlsi-2730	248	9	,	,	PUNCT
ajlsi-2730	248	10	m.	m.	NOUN
ajlsi-2730	248	11	,	,	PUNCT
ajlsi-2730	248	12	travassos	travassos	NUM
ajlsi-2730	248	13	,	,	PUNCT
ajlsi-2730	248	14	a.	a.	PROPN
ajlsi-2730	248	15	r.	r.	PROPN
ajlsi-2730	248	16	,	,	PUNCT
ajlsi-2730	248	17	soares	soares	PROPN
ajlsi-2730	248	18	-	-	PUNCT
ajlsi-2730	248	19	de	de	PROPN
ajlsi-2730	248	20	-	-	PROPN
ajlsi-2730	248	21	almeida	almeida	PROPN
ajlsi-2730	248	22	,	,	PUNCT
ajlsi-2730	248	23	l.	l.	PROPN
ajlsi-2730	248	24	,	,	PUNCT
ajlsi-2730	248	25	&	&	CCONJ
ajlsi-2730	248	26	metze	metze	PROPN
ajlsi-2730	248	27	,	,	PUNCT
ajlsi-2730	248	28	d.	d.	PROPN
ajlsi-2730	248	29	(	(	PUNCT
ajlsi-2730	248	30	2017	2017	NUM
ajlsi-2730	248	31	)	)	PUNCT
ajlsi-2730	248	32	.	.	PUNCT
ajlsi-2730	249	1	infliximab	infliximab	PROPN
ajlsi-2730	249	2	therapy	therapy	NOUN
ajlsi-2730	249	3	for	for	ADP
ajlsi-2730	249	4	netherton	netherton	NOUN
ajlsi-2730	249	5	syndrome	syndrome	PROPN
ajlsi-2730	249	6	:	:	PUNCT
ajlsi-2730	249	7	a	a	DET
ajlsi-2730	249	8	case	case	NOUN
ajlsi-2730	249	9	report	report	NOUN
ajlsi-2730	249	10	.	.	PUNCT
ajlsi-2730	250	1	jaad	jaad	NOUN
ajlsi-2730	250	2	case	case	NOUN
ajlsi-2730	250	3	reports	report	NOUN
ajlsi-2730	250	4	,	,	PUNCT
ajlsi-2730	250	5	3(6	3(6	NUM
ajlsi-2730	250	6	)	)	PUNCT
ajlsi-2730	250	7	,	,	PUNCT
ajlsi-2730	250	8	550	550	NUM
ajlsi-2730	250	9	-	-	SYM
ajlsi-2730	250	10	552	552	NUM
ajlsi-2730	250	11	.	.	PUNCT
ajlsi-2730	251	1	sethuraman	sethuraman	NOUN
ajlsi-2730	251	2	,	,	PUNCT
ajlsi-2730	251	3	g.	g.	PROPN
ajlsi-2730	251	4	,	,	PUNCT
ajlsi-2730	251	5	marwaha	marwaha	PROPN
ajlsi-2730	251	6	,	,	PUNCT
ajlsi-2730	251	7	r.	r.	PROPN
ajlsi-2730	251	8	k.	k.	PROPN
ajlsi-2730	251	9	,	,	PUNCT
ajlsi-2730	251	10	challa	challa	PROPN
ajlsi-2730	251	11	,	,	PUNCT
ajlsi-2730	251	12	a.	a.	NOUN
ajlsi-2730	251	13	,	,	PUNCT
ajlsi-2730	251	14	yenamandra	yenamandra	PROPN
ajlsi-2730	251	15	,	,	PUNCT
ajlsi-2730	251	16	v.	v.	PROPN
ajlsi-2730	251	17	k.	k.	PROPN
ajlsi-2730	251	18	,	,	PUNCT
ajlsi-2730	251	19	ramakrishnan	ramakrishnan	PROPN
ajlsi-2730	251	20	,	,	PUNCT
ajlsi-2730	251	21	l.	l.	PROPN
ajlsi-2730	251	22	,	,	PUNCT
ajlsi-2730	251	23	thulkar	thulkar	PROPN
ajlsi-2730	251	24	,	,	PUNCT
ajlsi-2730	251	25	s.	s.	PROPN
ajlsi-2730	251	26	,	,	PUNCT
ajlsi-2730	251	27	&	&	CCONJ
ajlsi-2730	251	28	sharma	sharma	PROPN
ajlsi-2730	251	29	,	,	PUNCT
ajlsi-2730	251	30	v.	v.	PROPN
ajlsi-2730	251	31	k.	k.	PROPN
ajlsi-2730	251	32	(	(	PUNCT
ajlsi-2730	251	33	2016	2016	NUM
ajlsi-2730	251	34	)	)	PUNCT
ajlsi-2730	251	35	.	.	PUNCT
ajlsi-2730	252	1	vitamin	vitamin	NOUN
ajlsi-2730	253	1	d	d	NOUN
ajlsi-2730	253	2	:	:	PUNCT
ajlsi-2730	253	3	a	a	DET
ajlsi-2730	253	4	new	new	ADJ
ajlsi-2730	253	5	promising	promising	ADJ
ajlsi-2730	253	6	therapy	therapy	NOUN
ajlsi-2730	253	7	for	for	ADP
ajlsi-2730	253	8	congenital	congenital	ADJ
ajlsi-2730	253	9	ichthyosis	ichthyosis	NOUN
ajlsi-2730	253	10	.	.	PUNCT
ajlsi-2730	254	1	pediatrics	pediatric	NOUN
ajlsi-2730	254	2	,	,	PUNCT
ajlsi-2730	254	3	137(1	137(1	NUM
ajlsi-2730	254	4	)	)	PUNCT
ajlsi-2730	254	5	.	.	PUNCT
ajlsi-2730	255	1	sticherling	sticherling	NOUN
ajlsi-2730	255	2	,	,	PUNCT
ajlsi-2730	255	3	m.	m.	NOUN
ajlsi-2730	255	4	(	(	PUNCT
ajlsi-2730	255	5	2020	2020	NUM
ajlsi-2730	255	6	)	)	PUNCT
ajlsi-2730	255	7	.	.	PUNCT
ajlsi-2730	256	1	dermatology	dermatology	NOUN
ajlsi-2730	256	2	part	part	NOUN
ajlsi-2730	256	3	2	2	NUM
ajlsi-2730	256	4	:	:	PUNCT
ajlsi-2730	256	5	ichthyoses	ichthyose	NOUN
ajlsi-2730	256	6	and	and	CCONJ
ajlsi-2730	256	7	psoriasis	psoriasis	NOUN
ajlsi-2730	256	8	.	.	PUNCT
ajlsi-2730	257	1	pediatric	pediatric	ADJ
ajlsi-2730	257	2	pharmacotherapy	pharmacotherapy	NOUN
ajlsi-2730	257	3	,	,	PUNCT
ajlsi-2730	257	4	153	153	NUM
ajlsi-2730	257	5	-	-	SYM
ajlsi-2730	257	6	175	175	NUM
ajlsi-2730	257	7	.	.	PUNCT
ajlsi-2730	258	1	takhtarova	takhtarova	PROPN
ajlsi-2730	258	2	,	,	PUNCT
ajlsi-2730	258	3	t.	t.	PROPN
ajlsi-2730	258	4	g.	g.	PROPN
ajlsi-2730	258	5	,	,	PUNCT
ajlsi-2730	258	6	khismatullina	khismatullina	PROPN
ajlsi-2730	258	7	,	,	PUNCT
ajlsi-2730	258	8	z.	z.	PROPN
ajlsi-2730	258	9	r.	r.	PROPN
ajlsi-2730	258	10	,	,	PUNCT
ajlsi-2730	258	11	panova	panova	PROPN
ajlsi-2730	258	12	,	,	PUNCT
ajlsi-2730	258	13	l.	l.	PROPN
ajlsi-2730	258	14	d.	d.	PROPN
ajlsi-2730	258	15	,	,	PUNCT
ajlsi-2730	258	16	&	&	CCONJ
ajlsi-2730	258	17	panova	panova	PROPN
ajlsi-2730	258	18	,	,	PUNCT
ajlsi-2730	258	19	a.	a.	NOUN
ajlsi-2730	258	20	n.	n.	NOUN
ajlsi-2730	258	21	(	(	PUNCT
ajlsi-2730	258	22	2021	2021	NUM
ajlsi-2730	258	23	)	)	PUNCT
ajlsi-2730	258	24	.	.	PUNCT
ajlsi-2730	259	1	ichthyosis	ichthyosis	NOUN
ajlsi-2730	259	2	(	(	PUNCT
ajlsi-2730	259	3	concept	concept	NOUN
ajlsi-2730	259	4	,	,	PUNCT
ajlsi-2730	259	5	pathohistology	pathohistology	NOUN
ajlsi-2730	259	6	,	,	PUNCT
ajlsi-2730	259	7	clinical	clinical	ADJ
ajlsi-2730	259	8	picture	picture	NOUN
ajlsi-2730	259	9	,	,	PUNCT
ajlsi-2730	259	10	treatment	treatment	NOUN
ajlsi-2730	259	11	)	)	PUNCT
ajlsi-2730	259	12	.	.	PUNCT
ajlsi-2730	260	1	vestnik	vestnik	PROPN
ajlsi-2730	260	2	dermatologii	dermatologii	PROPN
ajlsi-2730	260	3	i	i	PROPN
ajlsi-2730	260	4	venerologii	venerologii	NOUN
ajlsi-2730	260	5	,	,	PUNCT
ajlsi-2730	260	6	97(3	97(3	NUM
ajlsi-2730	260	7	)	)	PUNCT
ajlsi-2730	260	8	,	,	PUNCT
ajlsi-2730	260	9	6	6	NUM
ajlsi-2730	260	10	-	-	SYM
ajlsi-2730	260	11	13	13	NUM
ajlsi-2730	260	12	.	.	PUNCT
ajlsi-2730	261	1	wang	wang	PROPN
ajlsi-2730	261	2	,	,	PUNCT
ajlsi-2730	261	3	m.	m.	NOUN
ajlsi-2730	261	4	,	,	PUNCT
ajlsi-2730	261	5	zhai	zhai	PROPN
ajlsi-2730	261	6	,	,	PUNCT
ajlsi-2730	261	7	x.	x.	PROPN
ajlsi-2730	261	8	,	,	PUNCT
ajlsi-2730	261	9	li	li	PROPN
ajlsi-2730	261	10	,	,	PUNCT
ajlsi-2730	261	11	j.	j.	PROPN
ajlsi-2730	261	12	,	,	PUNCT
ajlsi-2730	261	13	guan	guan	PROPN
ajlsi-2730	261	14	,	,	PUNCT
ajlsi-2730	261	15	j.	j.	PROPN
ajlsi-2730	261	16	,	,	PUNCT
ajlsi-2730	261	17	xu	xu	PROPN
ajlsi-2730	261	18	,	,	PUNCT
ajlsi-2730	261	19	s.	s.	PROPN
ajlsi-2730	261	20	,	,	PUNCT
ajlsi-2730	261	21	li	li	PROPN
ajlsi-2730	261	22	,	,	PUNCT
ajlsi-2730	261	23	y.	y.	PROPN
ajlsi-2730	261	24	,	,	PUNCT
ajlsi-2730	261	25	&	&	CCONJ
ajlsi-2730	261	26	zhu	zhu	PROPN
ajlsi-2730	261	27	,	,	PUNCT
ajlsi-2730	261	28	h.	h.	PROPN
ajlsi-2730	261	29	(	(	PUNCT
ajlsi-2730	261	30	2021	2021	NUM
ajlsi-2730	261	31	)	)	PUNCT
ajlsi-2730	261	32	.	.	PUNCT
ajlsi-2730	262	1	the	the	DET
ajlsi-2730	262	2	role	role	NOUN
ajlsi-2730	262	3	of	of	ADP
ajlsi-2730	262	4	cytokines	cytokine	NOUN
ajlsi-2730	262	5	in	in	ADP
ajlsi-2730	262	6	predicting	predict	VERB
ajlsi-2730	262	7	the	the	DET
ajlsi-2730	262	8	response	response	NOUN
ajlsi-2730	262	9	and	and	CCONJ
ajlsi-2730	262	10	adverse	adverse	ADJ
ajlsi-2730	262	11	events	event	NOUN
ajlsi-2730	262	12	related	relate	VERB
ajlsi-2730	262	13	to	to	ADP
ajlsi-2730	262	14	immune	immune	ADJ
ajlsi-2730	262	15	checkpoint	checkpoint	NOUN
ajlsi-2730	262	16	inhibitors	inhibitor	NOUN
ajlsi-2730	262	17	.	.	PUNCT
ajlsi-2730	263	1	frontiers	frontier	NOUN
ajlsi-2730	263	2	in	in	ADP
ajlsi-2730	263	3	immunology	immunology	NOUN
ajlsi-2730	263	4	,	,	PUNCT
ajlsi-2730	263	5	12	12	NUM
ajlsi-2730	263	6	,	,	PUNCT
ajlsi-2730	263	7	670391	670391	NUM
ajlsi-2730	263	8	.	.	PUNCT
ajlsi-2730	264	1	yogarajah	yogarajah	PROPN
ajlsi-2730	264	2	,	,	PUNCT
ajlsi-2730	264	3	j.	j.	PROPN
ajlsi-2730	264	4	,	,	PUNCT
ajlsi-2730	264	5	gouveia	gouveia	PROPN
ajlsi-2730	264	6	,	,	PUNCT
ajlsi-2730	264	7	c.	c.	PROPN
ajlsi-2730	264	8	,	,	PUNCT
ajlsi-2730	264	9	iype	iype	NOUN
ajlsi-2730	264	10	,	,	PUNCT
ajlsi-2730	264	11	j.	j.	PROPN
ajlsi-2730	264	12	,	,	PUNCT
ajlsi-2730	264	13	häfliger	häfliger	NOUN
ajlsi-2730	264	14	,	,	PUNCT
ajlsi-2730	264	15	s.	s.	PROPN
ajlsi-2730	264	16	,	,	PUNCT
ajlsi-2730	264	17	schaller	schaller	PROPN
ajlsi-2730	264	18	,	,	PUNCT
ajlsi-2730	264	19	a.	a.	PROPN
ajlsi-2730	264	20	,	,	PUNCT
ajlsi-2730	264	21	nuoffer	nuoffer	NOUN
ajlsi-2730	264	22	,	,	PUNCT
ajlsi-2730	264	23	j.-m	j.-m	PROPN
ajlsi-2730	264	24	.	.	PUNCT
ajlsi-2730	264	25	,	,	PUNCT
ajlsi-2730	264	26	fux	fux	PROPN
ajlsi-2730	264	27	,	,	PUNCT
ajlsi-2730	264	28	m.	m.	NOUN
ajlsi-2730	264	29	,	,	PUNCT
ajlsi-2730	264	30	&	&	CCONJ
ajlsi-2730	264	31	gautschi	gautschi	PROPN
ajlsi-2730	264	32	,	,	PUNCT
ajlsi-2730	264	33	m.	m.	NOUN
ajlsi-2730	264	34	(	(	PUNCT
ajlsi-2730	264	35	2021	2021	NUM
ajlsi-2730	264	36	)	)	PUNCT
ajlsi-2730	264	37	.	.	PUNCT
ajlsi-2730	265	1	efficacy	efficacy	NOUN
ajlsi-2730	265	2	and	and	CCONJ
ajlsi-2730	265	3	safety	safety	NOUN
ajlsi-2730	265	4	of	of	ADP
ajlsi-2730	265	5	secukinumab	secukinumab	NOUN
ajlsi-2730	265	6	for	for	ADP
ajlsi-2730	265	7	the	the	DET
ajlsi-2730	265	8	treatment	treatment	NOUN
ajlsi-2730	265	9	of	of	ADP
ajlsi-2730	265	10	severe	severe	ADJ
ajlsi-2730	265	11	abca12	abca12	NOUN
ajlsi-2730	265	12	deficiency‐related	deficiency‐relate	VERB
ajlsi-2730	265	13	ichthyosis	ichthyosis	NOUN
ajlsi-2730	265	14	in	in	ADP
ajlsi-2730	265	15	a	a	DET
ajlsi-2730	265	16	child	child	NOUN
ajlsi-2730	265	17	.	.	PUNCT
ajlsi-2730	266	1	skin	skin	NOUN
ajlsi-2730	266	2	health	health	NOUN
ajlsi-2730	266	3	and	and	CCONJ
ajlsi-2730	266	4	disease	disease	NOUN
ajlsi-2730	266	5	,	,	PUNCT
ajlsi-2730	266	6	1(2	1(2	NUM
ajlsi-2730	266	7	)	)	PUNCT
ajlsi-2730	266	8	,	,	PUNCT
ajlsi-2730	266	9	e25	e25	PROPN
ajlsi-2730	266	10	.	.	PUNCT
ajlsi-2730	266	11	zaenglein	zaenglein	PROPN
ajlsi-2730	266	12	,	,	PUNCT
ajlsi-2730	266	13	a.	a.	PROPN
ajlsi-2730	266	14	l.	l.	PROPN
ajlsi-2730	266	15	,	,	PUNCT
ajlsi-2730	266	16	levy	levy	NOUN
ajlsi-2730	266	17	,	,	PUNCT
ajlsi-2730	266	18	m.	m.	NOUN
ajlsi-2730	266	19	l.	l.	PROPN
ajlsi-2730	266	20	,	,	PUNCT
ajlsi-2730	266	21	stefanko	stefanko	PROPN
ajlsi-2730	266	22	,	,	PUNCT
ajlsi-2730	266	23	n.	n.	PROPN
ajlsi-2730	266	24	s.	s.	PROPN
ajlsi-2730	266	25	,	,	PUNCT
ajlsi-2730	266	26	benjamin	benjamin	PROPN
ajlsi-2730	266	27	,	,	PUNCT
ajlsi-2730	266	28	l.	l.	PROPN
ajlsi-2730	266	29	t.	t.	PROPN
ajlsi-2730	266	30	,	,	PUNCT
ajlsi-2730	266	31	bruckner	bruckner	PROPN
ajlsi-2730	266	32	,	,	PUNCT
ajlsi-2730	266	33	a.	a.	PROPN
ajlsi-2730	266	34	l.	l.	PROPN
ajlsi-2730	266	35	,	,	PUNCT
ajlsi-2730	266	36	choate	choate	PROPN
ajlsi-2730	266	37	,	,	PUNCT
ajlsi-2730	266	38	k.	k.	PROPN
ajlsi-2730	266	39	,	,	PUNCT
ajlsi-2730	266	40	craiglow	craiglow	NOUN
ajlsi-2730	266	41	,	,	PUNCT
ajlsi-2730	266	42	b.	b.	PROPN
ajlsi-2730	266	43	g.	g.	PROPN
ajlsi-2730	266	44	,	,	PUNCT
ajlsi-2730	266	45	digiovanna	digiovanna	PROPN
ajlsi-2730	266	46	,	,	PUNCT
ajlsi-2730	266	47	j.	j.	PROPN
ajlsi-2730	266	48	j.	j.	PROPN
ajlsi-2730	266	49	,	,	PUNCT
ajlsi-2730	266	50	eichenfield	eichenfield	PROPN
ajlsi-2730	266	51	,	,	PUNCT
ajlsi-2730	266	52	l.	l.	PROPN
ajlsi-2730	266	53	f.	f.	PROPN
ajlsi-2730	266	54	,	,	PUNCT
ajlsi-2730	266	55	&	&	CCONJ
ajlsi-2730	266	56	elias	elias	PROPN
ajlsi-2730	266	57	,	,	PUNCT
ajlsi-2730	266	58	p.	p.	NOUN
ajlsi-2730	266	59	(	(	PUNCT
ajlsi-2730	266	60	2021	2021	NUM
ajlsi-2730	266	61	)	)	PUNCT
ajlsi-2730	266	62	.	.	PUNCT
ajlsi-2730	267	1	consensus	consensus	NOUN
ajlsi-2730	267	2	recommendations	recommendation	NOUN
ajlsi-2730	267	3	for	for	ADP
ajlsi-2730	267	4	the	the	DET
ajlsi-2730	267	5	use	use	NOUN
ajlsi-2730	267	6	of	of	ADP
ajlsi-2730	267	7	retinoids	retinoid	NOUN
ajlsi-2730	267	8	in	in	ADP
ajlsi-2730	267	9	ichthyosis	ichthyosis	NOUN
ajlsi-2730	267	10	and	and	CCONJ
ajlsi-2730	267	11	other	other	ADJ
ajlsi-2730	267	12	disorders	disorder	NOUN
ajlsi-2730	267	13	of	of	ADP
ajlsi-2730	267	14	cornification	cornification	NOUN
ajlsi-2730	267	15	in	in	ADP
ajlsi-2730	267	16	children	child	NOUN
ajlsi-2730	267	17	and	and	CCONJ
ajlsi-2730	267	18	adolescents	adolescent	NOUN
ajlsi-2730	267	19	.	.	PUNCT
ajlsi-2730	268	1	pediatric	pediatric	ADJ
ajlsi-2730	268	2	dermatology	dermatology	NOUN
ajlsi-2730	268	3	,	,	PUNCT
ajlsi-2730	268	4	38(1	38(1	NUM
ajlsi-2730	268	5	)	)	PUNCT
ajlsi-2730	268	6	,	,	PUNCT
ajlsi-2730	268	7	164	164	NUM
ajlsi-2730	268	8	-	-	SYM
ajlsi-2730	268	9	180	180	NUM
ajlsi-2730	268	10	.	.	PUNCT