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Vol.8, Issue 5; September-October 2023; 

ISSN: 2994-0524 

Impact Factor: 6.14 

1252 Columbia Rd NW, Washington DC, United States 

https://topjournals.org/index.php/AJMPE; mail: topacademicjournals@gmail.com 

 

 

 

 

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HERBAL ALLIES FOR YOUR GUMS: A LOOK AT MODERN NATURAL 

MEDICINE FOR PERIODONTAL CARE  
 

 

Dr. Wei Zhang, 

Department of Stomatology, Hospital of Xinjiang Medical University, Urumqi, China 

 

Abstract: Chronic Periodontitis (CP) is a prevalent chronic infectious disease that affects a significant portion of 

the global population, leading to tooth loss and impaired oral health. Current clinical treatments for periodontal 

disease involve basic interventions, local drug therapy, and post-treatment prevention strategies. However, the 

use of conventional treatments such as chlorhexidine and antibiotics may disrupt oral flora and contribute to the 

development of drug-resistant pathogens. As a result, there is a growing interest in natural, plant-derived oral care 

products as alternative solutions. Natural medicines, including Acacia arabica, aloe vera, neem, turmeric, 

lemongrass, camellia, and comfrey, offer promising antibacterial, anti-inflammatory, antiseptic, and antifungal 

properties, along with potential wound-healing benefits. This review explores the use of these natural products as 

topical therapeutic agents for the management of periodontitis, shedding light on their efficacy, safety, and 

potential to enhance periodontal health. 

Keywords: Chronic Periodontitis, oral care products, natural medicines, plant-derived agents, periodontal health 

 

 

Introduction  

Chronic Periodontitis (CP) is a chronic infectious disease and the leading cause of tooth loss in our adult 

population, CP affects 10-15% of the world's population and is caused by bacterial inflammation in the gum 

pockets that can destroy the tissues around the teeth[1]. Treatment therefore aims to prevent further progression of 

the disease, with the aim of reducing the risk of tooth loss, minimizing the symptoms and sensation of the disease 

and possibly restoring lost periodontal tissue[2]. The current clinical treatment of periodontal disease consists of 

basic treatment, supplemented by local treatment with drugs and post-treatment prevention and treatment. In the 

adjunctive treatment of periodontitis, chlorhexidine and antibiotics can control plaque and gingivitis, but it can 

imbalance the oral flora. The development of multidrug-resistant pathogens and the need for economical, safe 

and effective products has led to the development of plant-derived alternative oral care products. Natural 

medicines have recently attracted increasing interest. There is a growing public interest in natural or herbal health 

care products, especially for patients with chronic diseases[3]. Natural products including Acacia arabica, aloe 

vera, neem, turmeric, lemongrass, camellia and comfrey have antibacterial, anti-inflammatory, antiseptic and 

antifungal properties and may promote wound healing[4]. Therefore, this paper provides a review of topical 

therapeutic agents for periodontitis.  

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 American Journal of Medical and Physical Education 
Vol.8, Issue 5; September-October 2023; 

ISSN: 2994-0524 

Impact Factor: 6.14 

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1. Chronic periodontitis pathogenic factors  

Periodontal disease is a chronic inflammatory disease in which plaque biofilm is the initiating factor. As the 

disease progresses, periodontal tissues are gradually destroyed, resorption of alveolar bone occurs, and clinical 

symptoms such as bleeding and recession of the gums, loosening and even loss of teeth occur. It is due to the 

exposure of the host periodontal tissue to a microbiota that adheres to the teeth in the form of biofilm-long known 

as plaque. The bacteria (and possibly other microorganisms such as viruses, fungi and parasites) interact with 

each other and with the host. The development of periodontitis is accompanied by a dramatic change in the 

composition of the subgingival flora, and in most cases a different gram-negative flora emerges than the one 

enriched during gingivitis. Among the enriched flora are the classically described red complexes, including 

Fosetanella (formerly known as Fosetylomycetes), Porphyromonas gingivalis, and the dense spirochete of dental 

tartar[5]. Over time, the resulting dysregulated microbiota, combined with dysregulated host inflammation, 

promotes the growth of specific microorganisms within the biofilm, producing substances that exacerbate 

inflammation and, in some patients, lead to tissue destruction and tooth loss.  

2. Antibiotic drugs to assist in the treatment of periodontitis  

In severe chronic periodontitis, recent randomized clinical trials[6,7] and a systematic review and Metaanalysis[8,9] 

reported significant improvements in scaling and root planing outcomes when antibiotics were administered 

systemically or topically as an adjunctive therapy. In a recent systematic evaluation of a total of 28 double-blind 

randomized controlled trials investigating the benefit of systemic antibiotics as an adjunctive therapy to scaling 

and root planing in the treatment of moderate to severe periodontitis, this Meta-analysis reported a statistically 

significant reduction in mean full-mouth probing depth of 0.448 mm and a statistically significant increase in 

attachment level of 0.389 mm in the antibiotic control group at 6-month follow-up. This improvement appeared 

to persist at the 12-month follow-up (i.e., a 0.485-mm decrease in probing depth and a 0.285-mm increase in 

attachment level). These improvements were further supported by a reduction in probing bleeding and a reduction 

in periodontal pocket depth. Amoxicillin and metronidazole had the most dramatic improvements[10]. For 

localized sites with deep periodontal pockets, administration of topically delivered antibiotics (i.e., minocycline 

microspheres[11,12]) or antimicrobial medications (i.e., chlorhexidine chips[13,14]) may be considered. However, 

they also have adverse effects such as staining of the teeth or mucosa, cytotoxicity, and can imbalance the normal 

oral flora with long-term use, so they should not be used for long periods of time either.  

3. Probiotics and vaccines to assist in the treatment of periodontitis  

Probiotics have recently received a lot of attention as a potential method of preventing periodontitis. Probiotics 

are defined by the Food and Agriculture Organization/World Health Organization as "living microorganisms" 

that confer health benefits to their hosts. Many mechanisms have been proposed to explain the benefits of 

probiotics. Probiotics can reverse inflammation-induced epithelial damage by stimulating the upregulation of 

structural proteins. These probiotics may also colonize and proliferate to deprive pathogenic bacteria of nutrients 

and thus inhibit their growth. Probiotics may also produce antimicrobial products that inhibit Gram-negative 

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 American Journal of Medical and Physical Education 
Vol.8, Issue 5; September-October 2023; 

ISSN: 2994-0524 

Impact Factor: 6.14 

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bacteria, such as acetic acid and lactic acid. In addition, probiotics may influence the host to downregulate 

pathways that may damage host tissues while upregulating other pathways that inhibit the growth or virulence of 

pathogens[15-17] . Another type of periodontitis that is thought to be preventable is the development of vaccines. 

Vaccines have long been used in medicine as an effective public health intervention to prevent disease. 

Periodontal vaccines are a topic of research from the 1970s and are a proposed method of preventing periodontitis 

based on its multiple microbial etiology. Several research groups have reported a periodontal vaccine under 

development that targets antigens of specific oral gram-negative anaerobic pathogens[15] .  

4. Natural medicine to assist in the treatment of periodontitis  

The relationship between herbal medicine and oral microecology has become a hot research topic in recent years, 

where herbal medicine, as a natural agent with low side effects and wide sources, has shown good efficacy in the 

management of oral diseases such as caries, periodontal disease, oral mucosal disease and even oral tumors [18]. 

A systematic evaluation assessed the effectiveness of herbal oral care products in reducing plaque and gingivitis, 

and the use of adjunctive plant-derived active ingredients in the management of patients with periodontitis can be 

an alternative to chemicals because of their significant benefits in clinical outcomes and lack of associated side 

effects, and can be recommended as an alternative[19]. The main natural drugs that are currently used in periodontal 

disease treatment studies are comfrey, honeysuckle, pentaphyllum, propolis, bitter ginseng, and red peony.  

4.1 Lithospermum  

The Xinjiang native herb soft comfrey, the best quality among comfrey, contains the fat-soluble naphthoquinone 

component comfreyin and its derivatives as its main active ingredients to exert antiinflammatory effects[20]. As a 

traditional Chinese herb, comfrey has anti-inflammatory activity and its main constituent comfreyin inhibits the 

expression of pro-inflammatory mediators in the ischemic cortex, comfreyin inhibits IL-6β- or TNF-α-stimulated 

production of IL-8, IL-20 and CCL1 in HPDLC [21]. Meanwhile, comfrey has antibacterial, antiviral and 

immunomodulatory effects[22], comfreyin can downregulate the expression level of Toll-like receptor 4 stimulated 

by lipopolysaccharide, inhibit the secretion of IL-1β, IL-6 and TNF-α, and promote the secretion of IL-10. 

Treatment with comfrey polysaccharide inhibited the expression of TNF-α, IL-18 and other related inflammatory 

factors expressed by LPS-activated PBMC, possibly by suppressing the MAPK signaling pathway of PBMC and 

thus the high expression of LPS-induced inflammatory factors such as TNF-α[23]. Huang et al. reported that 

comfreyin treatment inhibited ERK phosphorylation while activating p38 in human lens epithelial cells MAPK 

and JNK phosphorylation in human lens epithelial cells [24] and in addition, Chen et al. found that Shikonin 

activated the p145 MAPK, ERK and JNK pathways in prostate cancer cells (PC-38 and DU3 cells)[25]. Wang Li 

et al. found that shikonin can promote osteoblast expression of OPG through the OPG/RANKL signaling axis, 

directly promoting osteoblast osteogenic differentiation and indirectly inhibiting osteoclast differentiation to 

inhibit bone resorption and promote bone formation[26].  

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 American Journal of Medical and Physical Education 
Vol.8, Issue 5; September-October 2023; 

ISSN: 2994-0524 

Impact Factor: 6.14 

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4.2 Honeysuckle  

Honeysuckle is sweet in taste and cold in nature, and chlorogenic and isochlorogenic acids are its important 

antibacterial components. Honeysuckle has the effect of clearing heat and detoxifying, cooling wind and heat, 

and has a long-term inhibitory effect on many bacteria such as Gram-positive bacteria, Gram-negative bacteria 

and spirochetes, which can directly destroy toxins in the body. In an animal study, for the treatment of 

periodontitis, mechanical plaque control is still the preferred option, and the use of compound honeysuckle herbal 

mouthwash can achieve better results. The compound honeysuckle herbal mouthwash had no acute toxic effects 

on rats in the short term and had a significant reduction in inflammation in experimental periodontitis in rats[27].  

4.3 Pentaphyllum  

It is bitter, sour, flat and non-toxic. Pharmacological research shows that the main component in rhubarb is 

rhubarb anthraquinone derivative, which has antibacterial, anti-swelling and analgesic effects[28], and its 

antibacterial effect is achieved through the inhibition of bacterial nucleic acid respiratory process and 

biosynthesis. Pentaphyllum is known to be antibacterial, detoxifying, astringent, precipitates coagulated proteins, 

and inhibits bacterial biofilm formation[29]. To date, several studies have demonstrated the clinical effects of AE 

on periodontitis. In an animal study, YANG et al. found that Porphyromonas gingivalis induced periodontitis in 

rats with significantly lower alveolar bone resorption levels and periodontal pocket depth after periodontitis. 

amCase protein expression was significantly higher in the disease group than in healthy controls. However, 

rhodopsin inhibited periodontal inflammation by down-regulating AMCase expression in saliva and periodontal 

pocket tissue. Rhodopsin significantly reduced RANKL-stimulated osteoclast formation by regulating AMCase 

[30-31].  

4.4 Propolis  

Propolis, also known as propolis, is a dark, dense and viscous combination of resins and waxes composed of 

active natural ingredients such as volatile oils, plant balsam, phenolic acids, flavonoids, aromatic alcohols, fatty 

acids, mineral salts and vitamins. It is collected by bees from trees, buds, flowers and other plant products. 

Propolis has been shown to have antibacterial, anti-inflammatory, antioxidant, antiviral, antifungal, antitumor and 

hepatoprotective properties [32]. A study by Bhat et al. showed the role of propolis in reducing dental biofilm 

accumulation. Among 30 healthy students divided into 3 groups, the Forever Bright (propolis-containing) dental 

gel group had the lowest mean modified gingival marginal plaque index (MGMPI) score, which was significantly 

different from the other 2 groups. This double-blind randomized study showed that propolis-containing tooth gel 

or toothpaste was able to reduce the rate of biofilm accumulation.  

4.5 Bitter ginseng  

The active ingredients of bitter ginseng, bittersweetine and oxymatrine, were approved for hepatoprotective and 

immunomodulatory use in China more than 30 years ago. Numerous studies have found that bitter ginseng bases 

and oxymatrine have a wide range of biological activities[33-34], such as antibacterial, antiviral, antioxidant, anti-

inflammatory, antitumor, and cardioprotective, hepatic, pulmonary, and vascular effects. Among them, studies 

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ISSN: 2994-0524 

Impact Factor: 6.14 

1252 Columbia Rd NW, Washington DC, United States 

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on antitumor, antibacterial, antiviral, immunomodulatory, cytoprotective and antifibrotic effects have also been 

extended to the treatment of dentistry patients. According to Chen Ling et al.[35], rats were pre-divided into blank 

group, control group, and experimental group and intervened with oxymatrine, and then executed after 6 weeks 

to examine the alveolar bone loss, and the results showed that the alveolar bone resorption of rats after oxymatrine 

intervention was less than that of the control group.  

4.6 Red peony  

Red peony has the effect of clearing heat and cooling blood, dispersing blood stasis and relieving pain, and its 

extract has good antibacterial and anti-inflammatory effects[36]. Radix Paeoniae contains paeonol, which inhibits 

RANKL-induced activation of ERK, p38 and NF-κB in macrophages to inhibit osteoclastogenesis and 

ovariectomy-induced osteoporosis. In addition, Gong Yi et al. preliminarily described that the main components, 

targets of action and related pathways of Paeonia lactiflora have important research value in the prevention and 

treatment of CP[37].  

5. Conclusions  

Periodontal disease is defined as a multifactorial inflammatory disease characterized by destruction of the 

supporting tissues around the teeth (including periodontal ligaments, gums, and alveolar bone) and is a major 

cause of tooth loss if left untreated. Mechanical plaque removal has been shown to be ineffective in adult patients, 

and further measures are needed to establish good oral hygiene. In the general population, maintaining good 

plaque control with conventional products is difficult. Therefore, it is important to use adjunctive antiseptics to 

improve oral hygiene and further improve periodontal treatment response. The use of antiseptics is essential to 

assist periodontal treatment, especially when non-surgical periodontal treatment is inadequate. Chlorhexidine is 

considered the gold standard for periodontal antiseptic treatment and is widely used as an adjunctive antimicrobial 

agent for root surface leveling[38]. However, patient compliance is not ideal due to its disgusting taste and the 

staining it causes in teeth. Natural pharmaceutical products including mouthwashes, dental cleaners and gels have 

made advances in the past few years. The active ingredients in natural pharmaceutical oral products penetrate 

biofilms and prevent plaque buildup, thereby minimizing bacterial colonization of tooth surfaces. In addition, 

they have antimicrobial efficacy against caries and periodontal pathogens, while reducing the development of 

drug resistance due to their synergistic combination. Natural drug extracts also inhibit osteoclast differentiation 

as well as the expression of pro-inflammatory cytokines, thus inhibiting bone resorption in periodontitis. 

However, herbal medicines also have many drawbacks such as slow and short duration of action, long treatment 

period, and poorly defined therapeutic mechanisms.  

There are fewer studies on the mechanisms by which herbal medicines regulate oral microorganisms and thus 

influence disease progression and treatment from a macroscopic perspective, and in-depth investigations of the 

downstream genes and products that influence them are still lacking. In addition, there are some microbial-related 

diseases in the oral cavity, such as oral cancer, oral mucosal disease, peri-implantitis, etc., but few studies have 

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ISSN: 2994-0524 

Impact Factor: 6.14 

1252 Columbia Rd NW, Washington DC, United States 

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been conducted to correlate herbal medicine with these diseases by regulating oral microecological balance. 

Therefore, future directions can focus on herbal medicine to assist periodontitis prevention and treatment.  

References  

Gross A J, Paskett K T, Cheever V J, et al. Periodontitis: a global disease and the primary care provider's role 

[J]. Postgrad Med J, 2017, 93(1103): 560-565.   

Nakayama M, Ohara N. Molecular mechanisms of Porphyromonas gingivalis-host cell interaction on periodontal 

diseases [J]. Jpn Dent Sci Rev, 2017, 53(4): 134-140.   

Rashrash M, Schommer J C, Brown L M. Prevalence and Predictors of Herbal Medicine Use Among Adults in 

the United States [J]. J Patient Exp, 2017, 4(3): 108-113.   

Laleman I, Teughels W. Novel natural product-based oral topical rinses and toothpastes to prevent periodontal 

diseases [J]. Periodontol 2000, 2020, 84(1): 102-123.   

Meng Huanxin. Periodontology [M] People's Health Press, 2020: 31-47.   

Liaw A, Miller C, Nimmo A. Comparing the periodontal tissue response to non-surgical scaling and root planing 

alone, adjunctive azithromycin, or adjunctive amoxicillin plus metronidazole in generalized chronic 

moderate-to-severe periodontitis: a preliminary randomized controlled trial [J]. Aust Dent J, 2019, 64(2): 

145-152.   

Borges I, Faveri M, Figueiredo L C, et al. Different antibiotic protocols in the treatment of severe chronic 

periodontitis: a 1-year randomized trial [J]. J Clin Periodontol, 2017, 44(8): 822-832.   

McGowan K, McGowan T, Ivanovski S. Optimal dose and duration of amoxicillin-plusmetronidazole as an 

adjunct to non-surgical periodontal therapy: a systematic review and meta-analysis of randomized, 

placebo-controlled trials [J]. J Clin Periodontol, 2018, 45(1): 56-67.   

Nibali L, Koidou V P, Hamborg T, et al. Empirical or microbiologically guided systemic antimicrobials as 

adjuncts to non-surgical periodontal therapy? A systematic review [J]. J Clin Periodontol, 2019, 46(10): 

999-1012.   

Teughels W, Feres M, Oud V, et al. Adjunctive effect of systemic antimicrobials in periodontitis therapy: a 

systematic review and meta-analysis [J]. J Clin Periodontol, 2020, 47 Suppl 22: 257-281.   

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Impact Factor: 6.14 

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|  https://topjournals.org/index.php/AJMPE 

Matesanz-Pérez P, García-Gargallo M, Figuero E, et al. A systematic review on the effects of local antimicrobials 

as adjuncts to subgingival debridement, compared with subgingival debridement alone, in the treatment 

of chronic periodontitis [J]. J Clin Periodontol, 2013, 40(3): 227-241.   

Chackartchi T, Hamzani Y, Shapira L, et al. Effect of Subgingival Mechanical Debridement and Local Delivery 

of Chlorhexidine Gluconate Chip or Minocycline Hydrochloride Microspheres in Patients Enrolled in 

Supportive Periodontal Therapy: a Retrospective Analysis [J]. Oral Health Prev Dent, 2019, 17(2): 167-

171.   

Rosa C, Gomes J M L, Moraes S L D, et al. Use of chlorhexidine chips after scaling and root planning on 

periodontal disease: a systematic review and meta- analysis [J]. Saudi Dent J, 2021, 33(1): 1-10.   

Ma L, Diao X. Effect of chlorhexidine chip as an adjunct in non-surgical management of periodontal pockets: a 

meta-analysis [J]. BMC Oral Health, 2020, 20(1): 262.   

Myneni S R, Brocavich K, H H W. Biological strategies for the prevention of periodontal disease: Probiotics and 

vaccines [J]. Periodontol 2000, 2020, 84(1): 161-175.   

Haque MM, Yerex K, Kelekis-Cholakis A, et al. Advances in novel therapeutic approaches for periodontal 

diseases [J]. BMC Oral Health. 2022, 22(1): 492.   

Luo W, Li H, Ye F. Clinical therapeutic effects of probiotics in combination with antibiotics on periodontitis: a 

protocol for systematic review and meta-analysis [J]. Medicine (Baltimore), 2021, 100(4): e23755.   

Luo LJ, Shuang RY. Overview and prospects of Chinese medicine treatment for periodontal disease [J]. Journal 

of Endodontics and Periodontology, 2003, 13(9): 534-537.   

Chatzopoulos G S, Karakostas P, Kavakloglou S, et al. Clinical Effectiveness of Herbal Oral Care Products in 

Periodontitis Patients: A Systematic Review [J]. Int J Environ Res Public Health, 2022, 19(16).   

Kang Yingying, Xu Fang, Pu Yiping, et al. Determination of eight naphthoquinone components of Xinjiang 

Comfrey and optimization of its extraction process [J]. Chinese Journal of Traditional Chinese Medicine, 

2022, 37(08): 4720-4724.   

Cheng Min, Tang Jun, Li Shanshan. Progress of pharmacological activity of naphthoquinone components of 

Comfrey and its quantitative analysis method [J]. Journal of Pharmaceutical Sciences, 2018, 53(12): 2026-

2039.   

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ISSN: 2994-0524 

Impact Factor: 6.14 

1252 Columbia Rd NW, Washington DC, United States 

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8 | A m e r i c a n  J o u r n a l  o f  M e d i c a l  a n d  P h y s i c a l  E d u c a t i o n  

|  https://topjournals.org/index.php/AJMPE 

Guo C, He J, Song X, et al. Pharmacological properties and derivatives of shikonin-A review in recent years [J]. 

Pharmacol Res, 2019, 149: 104463.   

Li YJ, Tal Y. Study on the inhibition of lipopolysaccharide-induced macrophage inflammation by comfreyin 

through TLR4/NF-κB signaling pathway [J]. Anhui Medicine, 2017, 21(8): 1384-1387.  [24] Huang WR, 

Zhang Y, Tang X. Shikonin inhibits the proliferation of human lens epithelial cells by inducing apoptosis 

through ROS and caspase-dependent pathway. Molecules. 2014 Jun 11; 19(6):77857797.   

Chen Y, Zheng L, Liu J, Zhou Z, Cao X, Lv X, Chen F. Shikonin inhibits prostate cancer cells metastasis by 

reducing matrix metalloproteinase-2/-9 expression via AKT/mTOR and ROS/ERK1/2 pathways. Int 

Immunopharmacol. 2014 Aug;21(2):447-455.   

Wang Liping, Lin Jing, Bo Yujia, et al. Effects of comfrey on proliferation, differentiation, mineralization and 

osteogenesis-related gene expression in MC3T3⁃E1 cells [J]. Journal of Practical Medicine, 2022, 38(5): 

583-588.   

Brown I S. Current Advances in the Use of Lasers in Periodontal Therapy: A Laser‐Assisted New Attachment 

Procedure Case Series[J]. Clinical Advances in Periodontics, 2013, 3(2). DOI:10.1902/cap.2013.120087.  

Chen NN, Hou YP, Tang QL, et al. Study on the natural drug Pseudostellaria pentaphylla for the prevention and 

treatment of oral diseases and related mechanisms [J]. Dietary Health, 2016, 3(4):2021.   

Chen YF, Fang D, Wang LH. The therapeutic effect of Pseudostellaria pentaphylla on periodontal diseases [J]. 

Chinese Journal of Traditional Chinese Medicine, 2014, 32(5):1233-1235.   

Tan S. B., Xu J. S. Experimental study on the inhibitory effect of the non-phenolic component of Pentaphyllum 

album slow-release gel on chronic periodontitis in rats [J]. Journal of Kunming University of Science and 

Technology (Natural Science Edition), 2015, 40(02):103-107.   

Yang M, Shrestha SK, Soh Y, Heo SM. Effects of aloe-emodin on alveolar bone in Porphyromonas gingivalis-

induced periodontitis rat model: a pilot study. J Periodontal Implant Sci. 2022 Oct;52(5):383393.   

Yu Qian, Lin Jing, Zulikarjiang Ahebaiti, Zhao Jin*, Experimental study on the effect of Yili black bee propolis 

on biofilm of major caries-causing bacteria in the oral cavity, West China Journal of Stomatology: 2015, 

33(4): 343-346.   

Bhat N, Bapat S, Asawa K, Tak M, Chaturvedi P, Gupta VV, et al. The antiplaque efficacy of propolis-based 

herbal toothpaste: a crossover clinical study J Nat Sci Biol Med 2015;6(2):364-368  [34] Wang H, Tong 

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Y, Li W, et al. Enhanced ultrasound-assisted enzymatic hydrolysis extraction of quinolizidine alkaloids 

from Sophora alopecuroides L. seeds [J]. seeds [J]. J Nat Med, 2018, 72(2): 424432.   

Luo K, Chen L, Chen YL et al. Experimental study on the inhibition of alveolar bone resorption in rats with 

experimental periodontitis by oxidized bitter ginseng base [J]. Journal of Fujian Medical University, 2010, 

44(02):100-102.   

Zhang Jianjun, Li Wei, Le Na, Wang Yujie, Zhou Xue, Zhang Rui. Efficacy of Paeonia lactiflora and total 

monoterpenes of Paeonia lactiflora and total phenols of Paeonia lactiflora in clearing heat, cooling blood 

and dispersing stasis in rats with heat toxicity and blood stasis evidence[J]. Journal of Beijing University 

of Traditional Chinese Medicine, 2020, 43(03):196-202.   

Gong Yi, Wu Zeyu, Wang Chen, Zhao Jin. Study on the antibacterial effect of Radix Paeoniae Alba and its 

mechanism for the prevention and treatment of chronic periodontitis [J]. Dentistry, 2021, 41(05): 391-

397.   

Thangavelu A, Kaspar S S, Kathirvelu R P, et al. Chlorhexidine: An Elixir for Periodontics [J]. J Pharm Bioallied 

Sci, 2020, 12(Suppl 1): S57-S59.   

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