id	sid	tid	token	lemma	pos
ajmsi-1760	1	1	pa	pa	PROPN
ajmsi-1760	1	2	ge	ge	PROPN
ajmsi-1760	1	3	1	1	NUM
ajmsi-1760	1	4	pa	pa	PROPN
ajmsi-1760	1	5	ge	ge	PROPN
ajmsi-1760	1	6	44	44	NUM
ajmsi-1760	1	7	american	american	PROPN
ajmsi-1760	1	8	journal	journal	PROPN
ajmsi-1760	1	9	of	of	ADP
ajmsi-1760	1	10	medical	medical	ADJ
ajmsi-1760	1	11	science	science	NOUN
ajmsi-1760	1	12	and	and	CCONJ
ajmsi-1760	1	13	innovation	innovation	NOUN
ajmsi-1760	1	14	(	(	PUNCT
ajmsi-1760	1	15	ajmsi	ajmsi	NOUN
ajmsi-1760	1	16	)	)	PUNCT
ajmsi-1760	1	17	crispr	crispr	ADJ
ajmsi-1760	1	18	-	-	PUNCT
ajmsi-1760	1	19	cas9	cas9	NOUN
ajmsi-1760	1	20	genomic	genomic	NOUN
ajmsi-1760	1	21	editing	editing	NOUN
ajmsi-1760	1	22	as	as	ADP
ajmsi-1760	1	23	an	an	DET
ajmsi-1760	1	24	innovation	innovation	NOUN
ajmsi-1760	1	25	in	in	ADP
ajmsi-1760	1	26	the	the	DET
ajmsi-1760	1	27	management	management	NOUN
ajmsi-1760	1	28	of	of	ADP
ajmsi-1760	1	29	sickle	sickle	NOUN
ajmsi-1760	1	30	cell	cell	NOUN
ajmsi-1760	1	31	disease	disease	NOUN
ajmsi-1760	1	32	:	:	PUNCT
ajmsi-1760	1	33	a	a	DET
ajmsi-1760	1	34	systematic	systematic	ADJ
ajmsi-1760	1	35	review	review	NOUN
ajmsi-1760	1	36	solomon	solomon	PROPN
ajmsi-1760	1	37	musa1	musa1	PROPN
ajmsi-1760	1	38	,	,	PUNCT
ajmsi-1760	1	39	aloysius	aloysius	PROPN
ajmsi-1760	1	40	obinna	obinna	PROPN
ajmsi-1760	1	41	ikwuka2	ikwuka2	PROPN
ajmsi-1760	1	42	*	*	SYM
ajmsi-1760	1	43	,	,	PUNCT
ajmsi-1760	1	44	francis	francis	PROPN
ajmsi-1760	1	45	chigozie	chigozie	PROPN
ajmsi-1760	1	46	udeh2	udeh2	PROPN
ajmsi-1760	1	47	,	,	PUNCT
ajmsi-1760	1	48	abdullahi	abdullahi	PROPN
ajmsi-1760	1	49	adobanyi	adobanyi	PROPN
ajmsi-1760	1	50	musa3	musa3	PROPN
ajmsi-1760	1	51	,	,	PUNCT
ajmsi-1760	1	52	ugo	ugo	PROPN
ajmsi-1760	1	53	collins	collins	PROPN
ajmsi-1760	1	54	chukwuezie4	chukwuezie4	PROPN
ajmsi-1760	1	55	volume	volume	NOUN
ajmsi-1760	1	56	2	2	NUM
ajmsi-1760	1	57	issue	issue	NOUN
ajmsi-1760	1	58	2	2	NUM
ajmsi-1760	1	59	,	,	PUNCT
ajmsi-1760	1	60	year	year	NOUN
ajmsi-1760	1	61	2023	2023	NUM
ajmsi-1760	1	62	issn	issn	X
ajmsi-1760	1	63	:	:	PUNCT
ajmsi-1760	1	64	2836	2836	NUM
ajmsi-1760	1	65	-	-	SYM
ajmsi-1760	1	66	8509	8509	NUM
ajmsi-1760	1	67	(	(	PUNCT
ajmsi-1760	1	68	online	online	NOUN
ajmsi-1760	1	69	)	)	PUNCT
ajmsi-1760	1	70	doi	doi	NOUN
ajmsi-1760	1	71	:	:	PUNCT
ajmsi-1760	1	72	https://doi.org/10.54536/ajmsi.v2i2.1760	https://doi.org/10.54536/ajmsi.v2i2.1760	PROPN
ajmsi-1760	1	73	https://journals.e-palli.com/home/index.php/ajmsi	https://journals.e-palli.com/home/index.php/ajmsi	PROPN
ajmsi-1760	1	74	article	article	NOUN
ajmsi-1760	1	75	information	information	NOUN
ajmsi-1760	1	76	abstract	abstract	ADV
ajmsi-1760	1	77	received	receive	VERB
ajmsi-1760	1	78	:	:	PUNCT
ajmsi-1760	1	79	june	june	PROPN
ajmsi-1760	1	80	16	16	NUM
ajmsi-1760	1	81	,	,	PUNCT
ajmsi-1760	1	82	2023	2023	NUM
ajmsi-1760	1	83	accepted	accept	VERB
ajmsi-1760	1	84	:	:	PUNCT
ajmsi-1760	1	85	july	july	PROPN
ajmsi-1760	1	86	08	08	NUM
ajmsi-1760	1	87	,	,	PUNCT
ajmsi-1760	1	88	2023	2023	NUM
ajmsi-1760	1	89	published	publish	VERB
ajmsi-1760	1	90	:	:	PUNCT
ajmsi-1760	1	91	july	july	PROPN
ajmsi-1760	1	92	30	30	NUM
ajmsi-1760	1	93	,	,	PUNCT
ajmsi-1760	1	94	2023	2023	NUM
ajmsi-1760	1	95	genomic	genomic	NOUN
ajmsi-1760	1	96	editing	editing	NOUN
ajmsi-1760	1	97	is	be	AUX
ajmsi-1760	1	98	a	a	DET
ajmsi-1760	1	99	group	group	NOUN
ajmsi-1760	1	100	of	of	ADP
ajmsi-1760	1	101	technologies	technology	NOUN
ajmsi-1760	1	102	that	that	PRON
ajmsi-1760	1	103	scientists	scientist	NOUN
ajmsi-1760	1	104	have	have	AUX
ajmsi-1760	1	105	used	use	VERB
ajmsi-1760	1	106	to	to	PART
ajmsi-1760	1	107	alter	alter	VERB
ajmsi-1760	1	108	an	an	DET
ajmsi-1760	1	109	organism	organism	NOUN
ajmsi-1760	1	110	’s	’s	PART
ajmsi-1760	1	111	dna	dna	NOUN
ajmsi-1760	1	112	.	.	PUNCT
ajmsi-1760	2	1	of	of	ADP
ajmsi-1760	2	2	the	the	DET
ajmsi-1760	2	3	several	several	ADJ
ajmsi-1760	2	4	genomic	genomic	NOUN
ajmsi-1760	2	5	editing	editing	NOUN
ajmsi-1760	2	6	techniques	technique	NOUN
ajmsi-1760	2	7	,	,	PUNCT
ajmsi-1760	2	8	clustered	cluster	VERB
ajmsi-1760	2	9	regularly	regularly	ADV
ajmsi-1760	2	10	interspaced	interspace	VERB
ajmsi-1760	2	11	short	short	ADJ
ajmsi-1760	2	12	palindromic	palindromic	ADJ
ajmsi-1760	2	13	repeats	repeat	NOUN
ajmsi-1760	2	14	(	(	PUNCT
ajmsi-1760	2	15	crispr)-associated	crispr)-associate	VERB
ajmsi-1760	2	16	protein	protein	NOUN
ajmsi-1760	2	17	9	9	NUM
ajmsi-1760	2	18	(	(	PUNCT
ajmsi-1760	2	19	crispr	crispr	NOUN
ajmsi-1760	2	20	-	-	PUNCT
ajmsi-1760	2	21	cas9	cas9	NOUN
ajmsi-1760	2	22	)	)	PUNCT
ajmsi-1760	2	23	is	be	AUX
ajmsi-1760	2	24	well	well	ADV
ajmsi-1760	2	25	known	know	VERB
ajmsi-1760	2	26	.	.	PUNCT
ajmsi-1760	3	1	the	the	DET
ajmsi-1760	3	2	crispr	crispr	ADJ
ajmsi-1760	3	3	-	-	PUNCT
ajmsi-1760	3	4	cas9	cas9	NOUN
ajmsi-1760	3	5	system	system	NOUN
ajmsi-1760	3	6	is	be	AUX
ajmsi-1760	3	7	faster	fast	ADJ
ajmsi-1760	3	8	,	,	PUNCT
ajmsi-1760	3	9	cheaper	cheap	ADJ
ajmsi-1760	3	10	,	,	PUNCT
ajmsi-1760	3	11	more	more	ADV
ajmsi-1760	3	12	accurate	accurate	ADJ
ajmsi-1760	3	13	,	,	PUNCT
ajmsi-1760	3	14	more	more	ADV
ajmsi-1760	3	15	efficient	efficient	ADJ
ajmsi-1760	3	16	than	than	ADP
ajmsi-1760	3	17	other	other	ADJ
ajmsi-1760	3	18	genomic	genomic	NOUN
ajmsi-1760	3	19	editing	editing	NOUN
ajmsi-1760	3	20	methods	method	NOUN
ajmsi-1760	3	21	,	,	PUNCT
ajmsi-1760	3	22	and	and	CCONJ
ajmsi-1760	3	23	it	it	PRON
ajmsi-1760	3	24	is	be	AUX
ajmsi-1760	3	25	an	an	DET
ajmsi-1760	3	26	adaptation	adaptation	NOUN
ajmsi-1760	3	27	from	from	ADP
ajmsi-1760	3	28	bacteria	bacteria	NOUN
ajmsi-1760	3	29	’s	’s	PART
ajmsi-1760	3	30	immune	immune	ADJ
ajmsi-1760	3	31	mechanism	mechanism	NOUN
ajmsi-1760	3	32	.	.	PUNCT
ajmsi-1760	4	1	sickle	sickle	NOUN
ajmsi-1760	4	2	cell	cell	NOUN
ajmsi-1760	4	3	diseases	disease	NOUN
ajmsi-1760	4	4	(	(	PUNCT
ajmsi-1760	4	5	scds	scds	PROPN
ajmsi-1760	4	6	)	)	PUNCT
ajmsi-1760	4	7	are	be	AUX
ajmsi-1760	4	8	a	a	DET
ajmsi-1760	4	9	group	group	NOUN
ajmsi-1760	4	10	of	of	ADP
ajmsi-1760	4	11	monogenic	monogenic	ADJ
ajmsi-1760	4	12	diseases	disease	NOUN
ajmsi-1760	4	13	,	,	PUNCT
ajmsi-1760	4	14	and	and	CCONJ
ajmsi-1760	4	15	despite	despite	SCONJ
ajmsi-1760	4	16	their	their	PRON
ajmsi-1760	4	17	high	high	ADJ
ajmsi-1760	4	18	prevalence	prevalence	NOUN
ajmsi-1760	4	19	and	and	CCONJ
ajmsi-1760	4	20	chronic	chronic	ADJ
ajmsi-1760	4	21	debilitating	debilitate	VERB
ajmsi-1760	4	22	nature	nature	NOUN
ajmsi-1760	4	23	,	,	PUNCT
ajmsi-1760	4	24	they	they	PRON
ajmsi-1760	4	25	continue	continue	VERB
ajmsi-1760	4	26	to	to	PART
ajmsi-1760	4	27	have	have	VERB
ajmsi-1760	4	28	few	few	ADJ
ajmsi-1760	4	29	therapeutic	therapeutic	ADJ
ajmsi-1760	4	30	options	option	NOUN
ajmsi-1760	4	31	available	available	ADJ
ajmsi-1760	4	32	.	.	PUNCT
ajmsi-1760	5	1	the	the	DET
ajmsi-1760	5	2	aim	aim	NOUN
ajmsi-1760	5	3	of	of	ADP
ajmsi-1760	5	4	this	this	DET
ajmsi-1760	5	5	study	study	NOUN
ajmsi-1760	5	6	is	be	AUX
ajmsi-1760	5	7	to	to	PART
ajmsi-1760	5	8	review	review	VERB
ajmsi-1760	5	9	existing	exist	VERB
ajmsi-1760	5	10	literature	literature	NOUN
ajmsi-1760	5	11	and	and	CCONJ
ajmsi-1760	5	12	current	current	ADJ
ajmsi-1760	5	13	clinical	clinical	ADJ
ajmsi-1760	5	14	trials	trial	NOUN
ajmsi-1760	5	15	on	on	ADP
ajmsi-1760	5	16	crispr	crispr	ADJ
ajmsi-1760	5	17	-	-	PUNCT
ajmsi-1760	5	18	cas9	cas9	NOUN
ajmsi-1760	5	19	genomic	genomic	NOUN
ajmsi-1760	5	20	editing	editing	NOUN
ajmsi-1760	5	21	as	as	ADP
ajmsi-1760	5	22	an	an	DET
ajmsi-1760	5	23	innovation	innovation	NOUN
ajmsi-1760	5	24	in	in	ADP
ajmsi-1760	5	25	the	the	DET
ajmsi-1760	5	26	management	management	NOUN
ajmsi-1760	5	27	of	of	ADP
ajmsi-1760	5	28	sickle	sickle	NOUN
ajmsi-1760	5	29	cell	cell	NOUN
ajmsi-1760	5	30	disease	disease	NOUN
ajmsi-1760	5	31	(	(	PUNCT
ajmsi-1760	5	32	scd	scd	NOUN
ajmsi-1760	5	33	)	)	PUNCT
ajmsi-1760	5	34	,	,	PUNCT
ajmsi-1760	5	35	as	as	ADV
ajmsi-1760	5	36	well	well	ADV
ajmsi-1760	5	37	as	as	ADP
ajmsi-1760	5	38	the	the	DET
ajmsi-1760	5	39	current	current	ADJ
ajmsi-1760	5	40	state	state	NOUN
ajmsi-1760	5	41	of	of	ADP
ajmsi-1760	5	42	treatment	treatment	NOUN
ajmsi-1760	5	43	for	for	ADP
ajmsi-1760	5	44	scd	scd	NOUN
ajmsi-1760	5	45	.	.	PUNCT
ajmsi-1760	6	1	for	for	ADP
ajmsi-1760	6	2	this	this	DET
ajmsi-1760	6	3	systematic	systematic	ADJ
ajmsi-1760	6	4	review	review	NOUN
ajmsi-1760	6	5	,	,	PUNCT
ajmsi-1760	6	6	pubmed	pubmed	PROPN
ajmsi-1760	6	7	,	,	PUNCT
ajmsi-1760	6	8	google	google	PROPN
ajmsi-1760	6	9	scholar	scholar	NOUN
ajmsi-1760	6	10	,	,	PUNCT
ajmsi-1760	6	11	african	african	ADJ
ajmsi-1760	6	12	journals	journal	NOUN
ajmsi-1760	6	13	online	online	ADV
ajmsi-1760	6	14	(	(	PUNCT
ajmsi-1760	6	15	ajol	ajol	NOUN
ajmsi-1760	6	16	)	)	PUNCT
ajmsi-1760	6	17	,	,	PUNCT
ajmsi-1760	6	18	and	and	CCONJ
ajmsi-1760	6	19	clinicaltrial.gov	clinicaltrial.gov	NOUN
ajmsi-1760	6	20	articles	article	NOUN
ajmsi-1760	6	21	published	publish	VERB
ajmsi-1760	6	22	up	up	ADP
ajmsi-1760	6	23	to	to	ADP
ajmsi-1760	6	24	6th	6th	ADJ
ajmsi-1760	6	25	october	october	PROPN
ajmsi-1760	6	26	,	,	PUNCT
ajmsi-1760	6	27	2022	2022	NUM
ajmsi-1760	6	28	were	be	AUX
ajmsi-1760	6	29	searched	search	VERB
ajmsi-1760	6	30	.	.	PUNCT
ajmsi-1760	7	1	searches	search	NOUN
ajmsi-1760	7	2	for	for	ADP
ajmsi-1760	7	3	current	current	ADJ
ajmsi-1760	7	4	clinical	clinical	ADJ
ajmsi-1760	7	5	trials	trial	NOUN
ajmsi-1760	7	6	using	use	VERB
ajmsi-1760	7	7	crispr	crispr	NOUN
ajmsi-1760	7	8	-	-	PUNCT
ajmsi-1760	7	9	cas9	cas9	NOUN
ajmsi-1760	7	10	as	as	SCONJ
ajmsi-1760	7	11	intervention	intervention	NOUN
ajmsi-1760	7	12	were	be	AUX
ajmsi-1760	7	13	conducted	conduct	VERB
ajmsi-1760	7	14	by	by	ADP
ajmsi-1760	7	15	using	use	VERB
ajmsi-1760	7	16	the	the	DET
ajmsi-1760	7	17	search	search	NOUN
ajmsi-1760	7	18	terms	term	NOUN
ajmsi-1760	7	19	such	such	ADJ
ajmsi-1760	7	20	as	as	ADP
ajmsi-1760	7	21	sickle	sickle	NOUN
ajmsi-1760	7	22	cell	cell	NOUN
ajmsi-1760	7	23	disease	disease	NOUN
ajmsi-1760	7	24	,	,	PUNCT
ajmsi-1760	7	25	genomic	genomic	NOUN
ajmsi-1760	7	26	editing	editing	NOUN
ajmsi-1760	7	27	,	,	PUNCT
ajmsi-1760	7	28	genetics	genetic	NOUN
ajmsi-1760	7	29	,	,	PUNCT
ajmsi-1760	7	30	novel	novel	ADJ
ajmsi-1760	7	31	treatments	treatment	NOUN
ajmsi-1760	7	32	,	,	PUNCT
ajmsi-1760	7	33	hematopoietic	hematopoietic	ADJ
ajmsi-1760	7	34	stem	stem	NOUN
ajmsi-1760	7	35	cell	cell	NOUN
ajmsi-1760	7	36	transplantation	transplantation	NOUN
ajmsi-1760	7	37	,	,	PUNCT
ajmsi-1760	7	38	gene	gene	NOUN
ajmsi-1760	7	39	therapy	therapy	NOUN
ajmsi-1760	7	40	,	,	PUNCT
ajmsi-1760	7	41	and	and	CCONJ
ajmsi-1760	7	42	crispr	crispr	NOUN
ajmsi-1760	7	43	-	-	PUNCT
ajmsi-1760	7	44	ca9	ca9	NOUN
ajmsi-1760	7	45	.	.	PUNCT
ajmsi-1760	8	1	studies	study	NOUN
ajmsi-1760	8	2	cited	cite	VERB
ajmsi-1760	8	3	include	include	VERB
ajmsi-1760	8	4	meta	meta	NOUN
ajmsi-1760	8	5	-	-	PUNCT
ajmsi-1760	8	6	analyses	analysis	NOUN
ajmsi-1760	8	7	,	,	PUNCT
ajmsi-1760	8	8	original	original	ADJ
ajmsi-1760	8	9	research	research	NOUN
ajmsi-1760	8	10	,	,	PUNCT
ajmsi-1760	8	11	prospective	prospective	ADJ
ajmsi-1760	8	12	clinical	clinical	ADJ
ajmsi-1760	8	13	trials	trial	NOUN
ajmsi-1760	8	14	,	,	PUNCT
ajmsi-1760	8	15	online	online	ADJ
ajmsi-1760	8	16	abstracts	abstract	NOUN
ajmsi-1760	8	17	,	,	PUNCT
ajmsi-1760	8	18	literature	literature	NOUN
ajmsi-1760	8	19	reviews	review	NOUN
ajmsi-1760	8	20	,	,	PUNCT
ajmsi-1760	8	21	retrospective	retrospective	ADJ
ajmsi-1760	8	22	studies	study	NOUN
ajmsi-1760	8	23	,	,	PUNCT
ajmsi-1760	8	24	case	case	NOUN
ajmsi-1760	8	25	series	series	NOUN
ajmsi-1760	8	26	,	,	PUNCT
ajmsi-1760	8	27	and	and	CCONJ
ajmsi-1760	8	28	scientific	scientific	ADJ
ajmsi-1760	8	29	meetings	meeting	NOUN
ajmsi-1760	8	30	.	.	PUNCT
ajmsi-1760	9	1	the	the	DET
ajmsi-1760	9	2	primary	primary	ADJ
ajmsi-1760	9	3	search	search	NOUN
ajmsi-1760	9	4	obtained	obtain	VERB
ajmsi-1760	9	5	27,678	27,678	NUM
ajmsi-1760	9	6	articles	article	NOUN
ajmsi-1760	9	7	.	.	PUNCT
ajmsi-1760	10	1	following	follow	VERB
ajmsi-1760	10	2	a	a	DET
ajmsi-1760	10	3	review	review	NOUN
ajmsi-1760	10	4	of	of	ADP
ajmsi-1760	10	5	titles	title	NOUN
ajmsi-1760	10	6	and	and	CCONJ
ajmsi-1760	10	7	abstracts	abstract	NOUN
ajmsi-1760	10	8	,	,	PUNCT
ajmsi-1760	10	9	a	a	DET
ajmsi-1760	10	10	total	total	NOUN
ajmsi-1760	10	11	of	of	ADP
ajmsi-1760	10	12	32	32	NUM
ajmsi-1760	10	13	publications	publication	NOUN
ajmsi-1760	10	14	and	and	CCONJ
ajmsi-1760	10	15	6	6	NUM
ajmsi-1760	10	16	ongoing	ongoing	ADJ
ajmsi-1760	10	17	clinical	clinical	ADJ
ajmsi-1760	10	18	trials	trial	NOUN
ajmsi-1760	10	19	were	be	AUX
ajmsi-1760	10	20	included	include	VERB
ajmsi-1760	10	21	in	in	ADP
ajmsi-1760	10	22	this	this	DET
ajmsi-1760	10	23	systematic	systematic	ADJ
ajmsi-1760	10	24	review	review	NOUN
ajmsi-1760	10	25	based	base	VERB
ajmsi-1760	10	26	on	on	ADP
ajmsi-1760	10	27	the	the	DET
ajmsi-1760	10	28	recent	recent	ADJ
ajmsi-1760	10	29	evidence	evidence	NOUN
ajmsi-1760	10	30	-	-	PUNCT
ajmsi-1760	10	31	based	base	VERB
ajmsi-1760	10	32	management	management	NOUN
ajmsi-1760	10	33	of	of	ADP
ajmsi-1760	10	34	scd	scd	PROPN
ajmsi-1760	10	35	.	.	PUNCT
ajmsi-1760	11	1	crispr	crispr	ADJ
ajmsi-1760	11	2	-	-	PUNCT
ajmsi-1760	11	3	cas9	cas9	NOUN
ajmsi-1760	11	4	genomic	genomic	NOUN
ajmsi-1760	11	5	editing	editing	NOUN
ajmsi-1760	11	6	stands	stand	VERB
ajmsi-1760	11	7	out	out	ADP
ajmsi-1760	11	8	as	as	ADP
ajmsi-1760	11	9	a	a	DET
ajmsi-1760	11	10	novel	novel	NOUN
ajmsi-1760	11	11	,	,	PUNCT
ajmsi-1760	11	12	innovative	innovative	ADJ
ajmsi-1760	11	13	technology	technology	NOUN
ajmsi-1760	11	14	which	which	PRON
ajmsi-1760	11	15	has	have	VERB
ajmsi-1760	11	16	the	the	DET
ajmsi-1760	11	17	potential	potential	NOUN
ajmsi-1760	11	18	to	to	PART
ajmsi-1760	11	19	cure	cure	VERB
ajmsi-1760	11	20	scd	scd	NOUN
ajmsi-1760	11	21	in	in	ADP
ajmsi-1760	11	22	children	child	NOUN
ajmsi-1760	11	23	and	and	CCONJ
ajmsi-1760	11	24	adults	adult	NOUN
ajmsi-1760	11	25	with	with	ADP
ajmsi-1760	11	26	minimal	minimal	ADJ
ajmsi-1760	11	27	side	side	NOUN
ajmsi-1760	11	28	effects	effect	NOUN
ajmsi-1760	11	29	.	.	PUNCT
ajmsi-1760	12	1	six	six	NUM
ajmsi-1760	12	2	clinical	clinical	ADJ
ajmsi-1760	12	3	trials	trial	NOUN
ajmsi-1760	12	4	are	be	AUX
ajmsi-1760	12	5	ongoing	ongoing	ADJ
ajmsi-1760	12	6	with	with	ADP
ajmsi-1760	12	7	a	a	DET
ajmsi-1760	12	8	huge	huge	ADJ
ajmsi-1760	12	9	potential	potential	NOUN
ajmsi-1760	12	10	for	for	ADP
ajmsi-1760	12	11	scaling	scale	VERB
ajmsi-1760	12	12	up	up	ADP
ajmsi-1760	12	13	to	to	ADP
ajmsi-1760	12	14	phases	phase	NOUN
ajmsi-1760	12	15	3	3	NUM
ajmsi-1760	12	16	and	and	CCONJ
ajmsi-1760	12	17	4	4	NUM
ajmsi-1760	12	18	.	.	X
ajmsi-1760	13	1	keywords	keyword	VERB
ajmsi-1760	13	2	crispr	crispr	NOUN
ajmsi-1760	13	3	-	-	PUNCT
ajmsi-1760	13	4	cas9	cas9	NOUN
ajmsi-1760	13	5	,	,	PUNCT
ajmsi-1760	13	6	genomic	genomic	NOUN
ajmsi-1760	13	7	editing	editing	NOUN
ajmsi-1760	13	8	,	,	PUNCT
ajmsi-1760	13	9	innovation	innovation	NOUN
ajmsi-1760	13	10	,	,	PUNCT
ajmsi-1760	13	11	management	management	NOUN
ajmsi-1760	13	12	,	,	PUNCT
ajmsi-1760	13	13	sickle	sickle	NOUN
ajmsi-1760	13	14	cell	cell	NOUN
ajmsi-1760	13	15	disease	disease	NOUN
ajmsi-1760	13	16	,	,	PUNCT
ajmsi-1760	13	17	gene	gene	NOUN
ajmsi-1760	13	18	therapy	therapy	NOUN
ajmsi-1760	13	19	1	1	NUM
ajmsi-1760	13	20	clinical	clinical	ADJ
ajmsi-1760	13	21	projects	project	NOUN
ajmsi-1760	13	22	,	,	PUNCT
ajmsi-1760	13	23	xcene	xcene	ADJ
ajmsi-1760	13	24	research	research	NOUN
ajmsi-1760	13	25	,	,	PUNCT
ajmsi-1760	13	26	ikeja	ikeja	PROPN
ajmsi-1760	13	27	,	,	PUNCT
ajmsi-1760	13	28	nigeria	nigeria	PROPN
ajmsi-1760	13	29	2	2	NUM
ajmsi-1760	13	30	college	college	NOUN
ajmsi-1760	13	31	of	of	ADP
ajmsi-1760	13	32	medicine	medicine	NOUN
ajmsi-1760	13	33	and	and	CCONJ
ajmsi-1760	13	34	health	health	NOUN
ajmsi-1760	13	35	sciences	science	NOUN
ajmsi-1760	13	36	,	,	PUNCT
ajmsi-1760	13	37	american	american	PROPN
ajmsi-1760	13	38	international	international	PROPN
ajmsi-1760	13	39	university	university	PROPN
ajmsi-1760	13	40	west	west	PROPN
ajmsi-1760	13	41	africa	africa	PROPN
ajmsi-1760	13	42	,	,	PUNCT
ajmsi-1760	13	43	banjul	banjul	PROPN
ajmsi-1760	13	44	,	,	PUNCT
ajmsi-1760	13	45	the	the	DET
ajmsi-1760	13	46	gambia	gambia	PROPN
ajmsi-1760	13	47	3	3	NUM
ajmsi-1760	13	48	department	department	NOUN
ajmsi-1760	13	49	of	of	ADP
ajmsi-1760	13	50	family	family	NOUN
ajmsi-1760	13	51	medicine	medicine	NOUN
ajmsi-1760	13	52	,	,	PUNCT
ajmsi-1760	13	53	ahmadu	ahmadu	PROPN
ajmsi-1760	13	54	bello	bello	PROPN
ajmsi-1760	13	55	university	university	NOUN
ajmsi-1760	13	56	teaching	teaching	NOUN
ajmsi-1760	13	57	hospital	hospital	NOUN
ajmsi-1760	13	58	,	,	PUNCT
ajmsi-1760	13	59	zaria	zaria	PROPN
ajmsi-1760	13	60	,	,	PUNCT
ajmsi-1760	13	61	nigeria	nigeria	PROPN
ajmsi-1760	13	62	4	4	NUM
ajmsi-1760	13	63	department	department	NOUN
ajmsi-1760	13	64	of	of	ADP
ajmsi-1760	13	65	community	community	NOUN
ajmsi-1760	13	66	medicine	medicine	NOUN
ajmsi-1760	13	67	,	,	PUNCT
ajmsi-1760	13	68	university	university	NOUN
ajmsi-1760	13	69	of	of	ADP
ajmsi-1760	13	70	lagos	lagos	PROPN
ajmsi-1760	13	71	,	,	PUNCT
ajmsi-1760	13	72	surulere	surulere	ADV
ajmsi-1760	13	73	,	,	PUNCT
ajmsi-1760	13	74	nigeria	nigeria	PROPN
ajmsi-1760	13	75	*	*	PUNCT
ajmsi-1760	13	76	corresponding	correspond	VERB
ajmsi-1760	13	77	author	author	NOUN
ajmsi-1760	13	78	’s	’s	PART
ajmsi-1760	13	79	e	e	NOUN
ajmsi-1760	13	80	-	-	NOUN
ajmsi-1760	13	81	mail	mail	NOUN
ajmsi-1760	13	82	:	:	PUNCT
ajmsi-1760	14	1	aloysiussweet@yahoo.com	aloysiussweet@yahoo.com	X
ajmsi-1760	15	1	introduction	introduction	NOUN
ajmsi-1760	15	2	genetic	genetic	ADJ
ajmsi-1760	15	3	medicine	medicine	NOUN
ajmsi-1760	15	4	is	be	AUX
ajmsi-1760	15	5	a	a	DET
ajmsi-1760	15	6	newer	new	ADJ
ajmsi-1760	15	7	terminology	terminology	NOUN
ajmsi-1760	15	8	for	for	ADP
ajmsi-1760	15	9	medical	medical	ADJ
ajmsi-1760	15	10	genetics	genetic	NOUN
ajmsi-1760	15	11	and	and	CCONJ
ajmsi-1760	15	12	incorporates	incorporate	VERB
ajmsi-1760	15	13	areas	area	NOUN
ajmsi-1760	15	14	such	such	ADJ
ajmsi-1760	15	15	as	as	ADP
ajmsi-1760	15	16	gene	gene	NOUN
ajmsi-1760	15	17	therapy	therapy	NOUN
ajmsi-1760	15	18	.	.	PUNCT
ajmsi-1760	16	1	recent	recent	ADJ
ajmsi-1760	16	2	advances	advance	NOUN
ajmsi-1760	16	3	in	in	ADP
ajmsi-1760	16	4	medical	medical	ADJ
ajmsi-1760	16	5	genetics	genetic	NOUN
ajmsi-1760	16	6	are	be	AUX
ajmsi-1760	16	7	revealing	reveal	VERB
ajmsi-1760	16	8	etiologies	etiology	NOUN
ajmsi-1760	16	9	for	for	ADP
ajmsi-1760	16	10	morphologic	morphologic	ADJ
ajmsi-1760	16	11	,	,	PUNCT
ajmsi-1760	16	12	endocrine	endocrine	NOUN
ajmsi-1760	16	13	,	,	PUNCT
ajmsi-1760	16	14	cardiovascular	cardiovascular	ADJ
ajmsi-1760	16	15	,	,	PUNCT
ajmsi-1760	16	16	pulmonary	pulmonary	ADJ
ajmsi-1760	16	17	,	,	PUNCT
ajmsi-1760	16	18	ophthalmologic	ophthalmologic	ADJ
ajmsi-1760	16	19	,	,	PUNCT
ajmsi-1760	16	20	renal	renal	ADJ
ajmsi-1760	16	21	,	,	PUNCT
ajmsi-1760	16	22	psychiatric	psychiatric	NOUN
ajmsi-1760	16	23	,	,	PUNCT
ajmsi-1760	16	24	and	and	CCONJ
ajmsi-1760	16	25	dermatologic	dermatologic	ADJ
ajmsi-1760	16	26	conditions	condition	NOUN
ajmsi-1760	16	27	(	(	PUNCT
ajmsi-1760	16	28	ikwuka	ikwuka	ADJ
ajmsi-1760	16	29	,	,	PUNCT
ajmsi-1760	16	30	2023a	2023a	NUM
ajmsi-1760	16	31	)	)	PUNCT
ajmsi-1760	16	32	.	.	PUNCT
ajmsi-1760	17	1	sickle	sickle	NOUN
ajmsi-1760	17	2	cell	cell	NOUN
ajmsi-1760	17	3	disease	disease	NOUN
ajmsi-1760	17	4	(	(	PUNCT
ajmsi-1760	17	5	scd	scd	NOUN
ajmsi-1760	17	6	)	)	PUNCT
ajmsi-1760	17	7	encompasses	encompass	VERB
ajmsi-1760	17	8	a	a	DET
ajmsi-1760	17	9	group	group	NOUN
ajmsi-1760	17	10	of	of	ADP
ajmsi-1760	17	11	blood	blood	NOUN
ajmsi-1760	17	12	disorders	disorder	NOUN
ajmsi-1760	17	13	resulting	result	VERB
ajmsi-1760	17	14	from	from	ADP
ajmsi-1760	17	15	inheriting	inherit	VERB
ajmsi-1760	17	16	two	two	NUM
ajmsi-1760	17	17	mutated	mutate	VERB
ajmsi-1760	17	18	copies	copy	NOUN
ajmsi-1760	17	19	of	of	ADP
ajmsi-1760	17	20	the	the	DET
ajmsi-1760	17	21	β	β	NOUN
ajmsi-1760	17	22	-	-	ADJ
ajmsi-1760	17	23	globin	globin	ADJ
ajmsi-1760	17	24	gene	gene	NOUN
ajmsi-1760	17	25	(	(	PUNCT
ajmsi-1760	17	26	hbb	hbb	PROPN
ajmsi-1760	17	27	)	)	PUNCT
ajmsi-1760	17	28	from	from	ADP
ajmsi-1760	17	29	both	both	DET
ajmsi-1760	17	30	parents	parent	NOUN
ajmsi-1760	17	31	(	(	PUNCT
ajmsi-1760	17	32	frangoul	frangoul	ADJ
ajmsi-1760	17	33	,	,	PUNCT
ajmsi-1760	17	34	2021	2021	NUM
ajmsi-1760	17	35	)	)	PUNCT
ajmsi-1760	17	36	.	.	PUNCT
ajmsi-1760	18	1	hbb	hbb	PROPN
ajmsi-1760	18	2	,	,	PUNCT
ajmsi-1760	18	3	located	locate	VERB
ajmsi-1760	18	4	on	on	ADP
ajmsi-1760	18	5	chromosome	chromosome	NOUN
ajmsi-1760	18	6	11p15.5	11p15.5	NUM
ajmsi-1760	18	7	,	,	PUNCT
ajmsi-1760	18	8	encodes	encode	VERB
ajmsi-1760	18	9	the	the	DET
ajmsi-1760	18	10	β	β	NOUN
ajmsi-1760	18	11	-	-	NOUN
ajmsi-1760	18	12	chain	chain	NOUN
ajmsi-1760	18	13	of	of	ADP
ajmsi-1760	18	14	hemoglobin	hemoglobin	NOUN
ajmsi-1760	18	15	(	(	PUNCT
ajmsi-1760	18	16	onda	onda	NOUN
ajmsi-1760	18	17	,	,	PUNCT
ajmsi-1760	18	18	2005	2005	NUM
ajmsi-1760	18	19	)	)	PUNCT
ajmsi-1760	18	20	.	.	PUNCT
ajmsi-1760	19	1	in	in	ADP
ajmsi-1760	19	2	normal	normal	ADJ
ajmsi-1760	19	3	circumstances	circumstance	NOUN
ajmsi-1760	19	4	,	,	PUNCT
ajmsi-1760	19	5	humans	human	NOUN
ajmsi-1760	19	6	have	have	VERB
ajmsi-1760	19	7	three	three	NUM
ajmsi-1760	19	8	types	type	NOUN
ajmsi-1760	19	9	of	of	ADP
ajmsi-1760	19	10	hemoglobin	hemoglobin	NOUN
ajmsi-1760	19	11	:	:	PUNCT
ajmsi-1760	19	12	hemoglobin	hemoglobin	NOUN
ajmsi-1760	19	13	a	a	PRON
ajmsi-1760	19	14	(	(	PUNCT
ajmsi-1760	19	15	consisting	consist	VERB
ajmsi-1760	19	16	of	of	ADP
ajmsi-1760	19	17	2α	2α	NOUN
ajmsi-1760	19	18	and	and	CCONJ
ajmsi-1760	19	19	2β	2β	NUM
ajmsi-1760	19	20	chains	chain	NOUN
ajmsi-1760	19	21	)	)	PUNCT
ajmsi-1760	19	22	,	,	PUNCT
ajmsi-1760	19	23	hemoglobin	hemoglobin	NOUN
ajmsi-1760	19	24	a2	a2	PROPN
ajmsi-1760	19	25	(	(	PUNCT
ajmsi-1760	19	26	made	make	VERB
ajmsi-1760	19	27	up	up	ADP
ajmsi-1760	19	28	of	of	ADP
ajmsi-1760	19	29	2α	2α	NOUN
ajmsi-1760	19	30	and	and	CCONJ
ajmsi-1760	19	31	2δ	2δ	NUM
ajmsi-1760	19	32	chains	chain	NOUN
ajmsi-1760	19	33	)	)	PUNCT
ajmsi-1760	19	34	,	,	PUNCT
ajmsi-1760	19	35	and	and	CCONJ
ajmsi-1760	19	36	hemoglobin	hemoglobin	NOUN
ajmsi-1760	19	37	f	f	PROPN
ajmsi-1760	19	38	(	(	PUNCT
ajmsi-1760	19	39	hbf	hbf	PROPN
ajmsi-1760	19	40	)	)	PUNCT
ajmsi-1760	19	41	composed	compose	VERB
ajmsi-1760	19	42	of	of	ADP
ajmsi-1760	19	43	2α	2α	NOUN
ajmsi-1760	19	44	and	and	CCONJ
ajmsi-1760	19	45	2γ	2γ	NUM
ajmsi-1760	19	46	chains	chain	NOUN
ajmsi-1760	19	47	(	(	PUNCT
ajmsi-1760	19	48	hall	hall	NOUN
ajmsi-1760	19	49	,	,	PUNCT
ajmsi-1760	19	50	2020	2020	NUM
ajmsi-1760	19	51	)	)	PUNCT
ajmsi-1760	19	52	.	.	PUNCT
ajmsi-1760	20	1	in	in	ADP
ajmsi-1760	20	2	sickle	sickle	PROPN
ajmsi-1760	20	3	cell	cell	NOUN
ajmsi-1760	20	4	anemia	anemia	NOUN
ajmsi-1760	20	5	,	,	PUNCT
ajmsi-1760	20	6	the	the	DET
ajmsi-1760	20	7	most	most	ADV
ajmsi-1760	20	8	prevalent	prevalent	ADJ
ajmsi-1760	20	9	form	form	NOUN
ajmsi-1760	20	10	of	of	ADP
ajmsi-1760	20	11	scd	scd	PROPN
ajmsi-1760	20	12	,	,	PUNCT
ajmsi-1760	20	13	red	red	ADJ
ajmsi-1760	20	14	blood	blood	NOUN
ajmsi-1760	20	15	cells	cell	NOUN
ajmsi-1760	20	16	(	(	PUNCT
ajmsi-1760	20	17	rbcs	rbc	NOUN
ajmsi-1760	20	18	)	)	PUNCT
ajmsi-1760	20	19	contain	contain	VERB
ajmsi-1760	20	20	an	an	DET
ajmsi-1760	20	21	abnormal	abnormal	ADJ
ajmsi-1760	20	22	hemoglobin	hemoglobin	NOUN
ajmsi-1760	20	23	variant	variant	NOUN
ajmsi-1760	20	24	called	call	VERB
ajmsi-1760	20	25	hemoglobin	hemoglobin	NOUN
ajmsi-1760	20	26	s	s	PROPN
ajmsi-1760	20	27	,	,	PUNCT
ajmsi-1760	20	28	wherein	wherein	SCONJ
ajmsi-1760	20	29	each	each	PRON
ajmsi-1760	20	30	of	of	ADP
ajmsi-1760	20	31	the	the	DET
ajmsi-1760	20	32	two	two	NUM
ajmsi-1760	20	33	β	β	NOUN
ajmsi-1760	20	34	-	-	NOUN
ajmsi-1760	20	35	chains	chain	NOUN
ajmsi-1760	20	36	has	have	VERB
ajmsi-1760	20	37	a	a	DET
ajmsi-1760	20	38	specific	specific	ADJ
ajmsi-1760	20	39	mutation	mutation	NOUN
ajmsi-1760	20	40	(	(	PUNCT
ajmsi-1760	20	41	an	an	DET
ajmsi-1760	20	42	amino	amino	NOUN
ajmsi-1760	20	43	acid	acid	NOUN
ajmsi-1760	20	44	valine	valine	NOUN
ajmsi-1760	20	45	with	with	ADP
ajmsi-1760	20	46	codon	codon	PROPN
ajmsi-1760	20	47	gtg	gtg	PROPN
ajmsi-1760	20	48	substitutes	substitutes	PROPN
ajmsi-1760	20	49	glutamic	glutamic	ADJ
ajmsi-1760	20	50	acid	acid	NOUN
ajmsi-1760	20	51	with	with	ADP
ajmsi-1760	20	52	codon	codon	ADJ
ajmsi-1760	20	53	gag	gag	NOUN
ajmsi-1760	20	54	at	at	ADP
ajmsi-1760	20	55	position	position	NOUN
ajmsi-1760	20	56	6	6	NUM
ajmsi-1760	20	57	)	)	PUNCT
ajmsi-1760	20	58	(	(	PUNCT
ajmsi-1760	20	59	hall	hall	NOUN
ajmsi-1760	20	60	,	,	PUNCT
ajmsi-1760	20	61	2020	2020	NUM
ajmsi-1760	20	62	)	)	PUNCT
ajmsi-1760	20	63	.	.	PUNCT
ajmsi-1760	21	1	thus	thus	ADV
ajmsi-1760	21	2	,	,	PUNCT
ajmsi-1760	21	3	the	the	DET
ajmsi-1760	21	4	genetics	genetic	NOUN
ajmsi-1760	21	5	of	of	ADP
ajmsi-1760	21	6	scd	scd	PROPN
ajmsi-1760	21	7	(	(	PUNCT
ajmsi-1760	21	8	a	a	DET
ajmsi-1760	21	9	hemoglobinopathy	hemoglobinopathy	NOUN
ajmsi-1760	21	10	)	)	PUNCT
ajmsi-1760	21	11	is	be	AUX
ajmsi-1760	21	12	due	due	ADJ
ajmsi-1760	21	13	to	to	ADP
ajmsi-1760	21	14	the	the	DET
ajmsi-1760	21	15	substitution	substitution	NOUN
ajmsi-1760	21	16	of	of	ADP
ajmsi-1760	21	17	valine	valine	NOUN
ajmsi-1760	21	18	for	for	ADP
ajmsi-1760	21	19	glutamic	glutamic	ADJ
ajmsi-1760	21	20	acid	acid	NOUN
ajmsi-1760	21	21	at	at	ADP
ajmsi-1760	21	22	position	position	NOUN
ajmsi-1760	21	23	6	6	NUM
ajmsi-1760	21	24	of	of	ADP
ajmsi-1760	21	25	both	both	DET
ajmsi-1760	21	26	β	β	NOUN
ajmsi-1760	21	27	-	-	NOUN
ajmsi-1760	21	28	globin	globin	ADJ
ajmsi-1760	21	29	polypeptide	polypeptide	ADJ
ajmsi-1760	21	30	chains	chain	NOUN
ajmsi-1760	21	31	.	.	PUNCT
ajmsi-1760	22	1	hemoglobin	hemoglobin	NOUN
ajmsi-1760	22	2	f	f	PROPN
ajmsi-1760	22	3	persists	persist	VERB
ajmsi-1760	22	4	until	until	ADP
ajmsi-1760	22	5	about	about	ADV
ajmsi-1760	22	6	6	6	NUM
ajmsi-1760	22	7	weeks	week	NOUN
ajmsi-1760	22	8	of	of	ADP
ajmsi-1760	22	9	age	age	NOUN
ajmsi-1760	22	10	.	.	PUNCT
ajmsi-1760	23	1	thereafter	thereafter	ADV
ajmsi-1760	23	2	,	,	PUNCT
ajmsi-1760	23	3	hemoglobin	hemoglobin	NOUN
ajmsi-1760	23	4	a	a	DET
ajmsi-1760	23	5	persists	persist	NOUN
ajmsi-1760	23	6	throughout	throughout	ADP
ajmsi-1760	23	7	life	life	NOUN
ajmsi-1760	23	8	.	.	PUNCT
ajmsi-1760	24	1	the	the	DET
ajmsi-1760	24	2	mode	mode	NOUN
ajmsi-1760	24	3	of	of	ADP
ajmsi-1760	24	4	inheritance	inheritance	NOUN
ajmsi-1760	24	5	of	of	ADP
ajmsi-1760	24	6	scd	scd	NOUN
ajmsi-1760	24	7	is	be	AUX
ajmsi-1760	24	8	autosomal	autosomal	ADJ
ajmsi-1760	24	9	recessive	recessive	ADJ
ajmsi-1760	24	10	(	(	PUNCT
ajmsi-1760	24	11	ikwuka	ikwuka	ADJ
ajmsi-1760	24	12	,	,	PUNCT
ajmsi-1760	24	13	2023b	2023b	NUM
ajmsi-1760	24	14	)	)	PUNCT
ajmsi-1760	24	15	.	.	PUNCT
ajmsi-1760	25	1	hemoglobin	hemoglobin	NOUN
ajmsi-1760	25	2	,	,	PUNCT
ajmsi-1760	25	3	a	a	DET
ajmsi-1760	25	4	protein	protein	NOUN
ajmsi-1760	25	5	responsible	responsible	ADJ
ajmsi-1760	25	6	for	for	ADP
ajmsi-1760	25	7	oxygen	oxygen	NOUN
ajmsi-1760	25	8	transport	transport	NOUN
ajmsi-1760	25	9	in	in	ADP
ajmsi-1760	25	10	red	red	ADJ
ajmsi-1760	25	11	blood	blood	NOUN
ajmsi-1760	25	12	cells	cell	NOUN
ajmsi-1760	25	13	(	(	PUNCT
ajmsi-1760	25	14	rbcs	rbc	NOUN
ajmsi-1760	25	15	)	)	PUNCT
ajmsi-1760	25	16	,	,	PUNCT
ajmsi-1760	25	17	is	be	AUX
ajmsi-1760	25	18	synthesized	synthesize	VERB
ajmsi-1760	25	19	during	during	ADP
ajmsi-1760	25	20	erythropoiesis	erythropoiesis	NOUN
ajmsi-1760	25	21	(	(	PUNCT
ajmsi-1760	25	22	initiated	initiate	VERB
ajmsi-1760	25	23	in	in	ADP
ajmsi-1760	25	24	polychromatophil	polychromatophil	ADJ
ajmsi-1760	25	25	erythroblasts	erythroblast	NOUN
ajmsi-1760	25	26	and	and	CCONJ
ajmsi-1760	25	27	continuing	continue	VERB
ajmsi-1760	25	28	through	through	ADP
ajmsi-1760	25	29	the	the	DET
ajmsi-1760	25	30	reticulocyte	reticulocyte	NOUN
ajmsi-1760	25	31	stage	stage	NOUN
ajmsi-1760	25	32	)	)	PUNCT
ajmsi-1760	25	33	(	(	PUNCT
ajmsi-1760	25	34	hall	hall	NOUN
ajmsi-1760	25	35	,	,	PUNCT
ajmsi-1760	25	36	2020	2020	NUM
ajmsi-1760	25	37	)	)	PUNCT
ajmsi-1760	25	38	.	.	PUNCT
ajmsi-1760	26	1	erythropoiesis	erythropoiesis	NOUN
ajmsi-1760	26	2	is	be	AUX
ajmsi-1760	26	3	stimulated	stimulate	VERB
ajmsi-1760	26	4	and	and	CCONJ
ajmsi-1760	26	5	enhanced	enhance	VERB
ajmsi-1760	26	6	by	by	ADP
ajmsi-1760	26	7	erythropoietin	erythropoietin	PROPN
ajmsi-1760	26	8	,	,	PUNCT
ajmsi-1760	26	9	a	a	DET
ajmsi-1760	26	10	substance	substance	NOUN
ajmsi-1760	26	11	synthesized	synthesize	VERB
ajmsi-1760	26	12	by	by	ADP
ajmsi-1760	26	13	the	the	DET
ajmsi-1760	26	14	kidneys	kidney	NOUN
ajmsi-1760	26	15	.	.	PUNCT
ajmsi-1760	27	1	results	result	NOUN
ajmsi-1760	27	2	from	from	ADP
ajmsi-1760	27	3	different	different	ADJ
ajmsi-1760	27	4	studies	study	NOUN
ajmsi-1760	27	5	have	have	AUX
ajmsi-1760	27	6	shown	show	VERB
ajmsi-1760	27	7	that	that	SCONJ
ajmsi-1760	27	8	high	high	ADJ
ajmsi-1760	27	9	levels	level	NOUN
ajmsi-1760	27	10	of	of	ADP
ajmsi-1760	27	11	blood	blood	NOUN
ajmsi-1760	27	12	pressure	pressure	NOUN
ajmsi-1760	27	13	,	,	PUNCT
ajmsi-1760	27	14	glucose	glucose	NOUN
ajmsi-1760	27	15	and	and	CCONJ
ajmsi-1760	27	16	lipid	lipid	NOUN
ajmsi-1760	27	17	metabolic	metabolic	NOUN
ajmsi-1760	27	18	disorders	disorder	NOUN
ajmsi-1760	27	19	,	,	PUNCT
ajmsi-1760	27	20	asymptomatic	asymptomatic	ADJ
ajmsi-1760	27	21	hyperuricemia	hyperuricemia	NOUN
ajmsi-1760	27	22	,	,	PUNCT
ajmsi-1760	27	23	activation	activation	NOUN
ajmsi-1760	27	24	of	of	ADP
ajmsi-1760	27	25	systemic	systemic	ADJ
ajmsi-1760	27	26	immune	immune	ADJ
ajmsi-1760	27	27	inflammation	inflammation	NOUN
ajmsi-1760	27	28	and	and	CCONJ
ajmsi-1760	27	29	fibrogenesis	fibrogenesis	ADJ
ajmsi-1760	27	30	,	,	PUNCT
ajmsi-1760	27	31	contribute	contribute	VERB
ajmsi-1760	27	32	to	to	ADP
ajmsi-1760	27	33	kidney	kidney	NOUN
ajmsi-1760	27	34	damage	damage	NOUN
ajmsi-1760	27	35	(	(	PUNCT
ajmsi-1760	27	36	ikwuka	ikwuka	NOUN
ajmsi-1760	27	37	,	,	PUNCT
ajmsi-1760	27	38	2015	2015	NUM
ajmsi-1760	27	39	;	;	PUNCT
ajmsi-1760	27	40	ikwuka	ikwuka	PROPN
ajmsi-1760	27	41	,	,	PUNCT
ajmsi-1760	27	42	2017a	2017a	NUM
ajmsi-1760	27	43	;	;	PUNCT
ajmsi-1760	27	44	ikwuka	ikwuka	PROPN
ajmsi-1760	27	45	,	,	PUNCT
ajmsi-1760	27	46	2017c	2017c	NUM
ajmsi-1760	27	47	;	;	PUNCT
ajmsi-1760	27	48	ikwuka	ikwuka	ADJ
ajmsi-1760	27	49	,	,	PUNCT
ajmsi-1760	27	50	2017d	2017d	NUM
ajmsi-1760	27	51	;	;	PUNCT
ajmsi-1760	27	52	ikwuka	ikwuka	PROPN
ajmsi-1760	27	53	,	,	PUNCT
ajmsi-1760	27	54	2017e	2017e	NUM
ajmsi-1760	27	55	;	;	PUNCT
ajmsi-1760	27	56	ikwuka	ikwuka	X
ajmsi-1760	27	57	,	,	PUNCT
ajmsi-1760	27	58	2018d	2018d	NUM
ajmsi-1760	27	59	;	;	PUNCT
ajmsi-1760	27	60	ikwuka	ikwuka	NOUN
ajmsi-1760	27	61	,	,	PUNCT
ajmsi-1760	27	62	2019a	2019a	NUM
ajmsi-1760	27	63	;	;	PUNCT
ajmsi-1760	27	64	ikwuka	ikwuka	PROPN
ajmsi-1760	27	65	,	,	PUNCT
ajmsi-1760	27	66	2019c	2019c	NUM
ajmsi-1760	27	67	;	;	PUNCT
ajmsi-1760	27	68	ikwuka	ikwuka	NOUN
ajmsi-1760	27	69	,	,	PUNCT
ajmsi-1760	27	70	2022	2022	NUM
ajmsi-1760	27	71	;	;	PUNCT
ajmsi-1760	27	72	ikwuka	ikwuka	ADJ
ajmsi-1760	27	73	,	,	PUNCT
ajmsi-1760	27	74	2023d	2023d	NUM
ajmsi-1760	27	75	;	;	PUNCT
ajmsi-1760	27	76	ikwuka	ikwuka	NOUN
ajmsi-1760	27	77	,	,	PUNCT
ajmsi-1760	27	78	2023e	2023e	NUM
ajmsi-1760	27	79	;	;	PUNCT
ajmsi-1760	27	80	virstyuk	virstyuk	NOUN
ajmsi-1760	27	81	,	,	PUNCT
ajmsi-1760	27	82	2016	2016	NUM
ajmsi-1760	27	83	;	;	PUNCT
ajmsi-1760	27	84	virstyuk	virstyuk	NOUN
ajmsi-1760	27	85	,	,	PUNCT
ajmsi-1760	27	86	2017a	2017a	NUM
ajmsi-1760	27	87	;	;	PUNCT
ajmsi-1760	27	88	virstyuk	virstyuk	NOUN
ajmsi-1760	27	89	,	,	PUNCT
ajmsi-1760	27	90	2018a	2018a	NUM
ajmsi-1760	27	91	;	;	PUNCT
ajmsi-1760	27	92	virstyuk	virstyuk	NOUN
ajmsi-1760	27	93	,	,	PUNCT
ajmsi-1760	27	94	2019	2019	NUM
ajmsi-1760	27	95	;	;	PUNCT
ajmsi-1760	27	96	virstyuk	virstyuk	NOUN
ajmsi-1760	27	97	,	,	PUNCT
ajmsi-1760	27	98	2021a	2021a	NUM
ajmsi-1760	27	99	;	;	PUNCT
ajmsi-1760	27	100	virstyuk	virstyuk	NOUN
ajmsi-1760	27	101	,	,	PUNCT
ajmsi-1760	27	102	2021b	2021b	NUM
ajmsi-1760	27	103	)	)	PUNCT
ajmsi-1760	27	104	,	,	PUNCT
ajmsi-1760	27	105	which	which	PRON
ajmsi-1760	27	106	contributes	contribute	VERB
ajmsi-1760	27	107	to	to	ADP
ajmsi-1760	27	108	anemia	anemia	NOUN
ajmsi-1760	27	109	on	on	ADP
ajmsi-1760	27	110	account	account	NOUN
ajmsi-1760	27	111	of	of	ADP
ajmsi-1760	27	112	disturbed	disturbed	ADJ
ajmsi-1760	27	113	erythropoietin	erythropoietin	NOUN
ajmsi-1760	27	114	production	production	NOUN
ajmsi-1760	27	115	.	.	PUNCT
ajmsi-1760	28	1	however	however	ADV
ajmsi-1760	28	2	,	,	PUNCT
ajmsi-1760	28	3	dapagliflozin	dapagliflozin	NOUN
ajmsi-1760	28	4	which	which	PRON
ajmsi-1760	28	5	is	be	AUX
ajmsi-1760	28	6	a	a	DET
ajmsi-1760	28	7	sodium	sodium	NOUN
ajmsi-1760	28	8	-	-	PUNCT
ajmsi-1760	28	9	glucose	glucose	NOUN
ajmsi-1760	28	10	linked	link	VERB
ajmsi-1760	28	11	transporter	transporter	NOUN
ajmsi-1760	28	12	2	2	NUM
ajmsi-1760	28	13	(	(	PUNCT
ajmsi-1760	28	14	sglt-2	sglt-2	NOUN
ajmsi-1760	28	15	)	)	PUNCT
ajmsi-1760	28	16	inhibitor	inhibitor	NOUN
ajmsi-1760	28	17	and	and	CCONJ
ajmsi-1760	28	18	liraglutide	liraglutide	NOUN
ajmsi-1760	28	19	which	which	PRON
ajmsi-1760	28	20	is	be	AUX
ajmsi-1760	28	21	a	a	DET
ajmsi-1760	28	22	glucagon	glucagon	NOUN
ajmsi-1760	28	23	-	-	PUNCT
ajmsi-1760	28	24	like	like	ADJ
ajmsi-1760	28	25	peptide	peptide	NOUN
ajmsi-1760	28	26	1	1	NUM
ajmsi-1760	28	27	receptor	receptor	NOUN
ajmsi-1760	28	28	agonist	agonist	NOUN
ajmsi-1760	28	29	(	(	PUNCT
ajmsi-1760	28	30	glp-1	glp-1	NOUN
ajmsi-1760	28	31	ra	ra	NOUN
ajmsi-1760	28	32	)	)	PUNCT
ajmsi-1760	28	33	have	have	AUX
ajmsi-1760	28	34	been	be	AUX
ajmsi-1760	28	35	found	find	VERB
ajmsi-1760	28	36	to	to	PART
ajmsi-1760	28	37	increase	increase	VERB
ajmsi-1760	28	38	the	the	DET
ajmsi-1760	28	39	effectiveness	effectiveness	NOUN
ajmsi-1760	28	40	of	of	ADP
ajmsi-1760	28	41	treatment	treatment	NOUN
ajmsi-1760	28	42	and	and	CCONJ
ajmsi-1760	28	43	improve	improve	VERB
ajmsi-1760	28	44	the	the	DET
ajmsi-1760	28	45	clinical	clinical	ADJ
ajmsi-1760	28	46	course	course	NOUN
ajmsi-1760	28	47	of	of	ADP
ajmsi-1760	28	48	disease	disease	NOUN
ajmsi-1760	28	49	in	in	ADP
ajmsi-1760	28	50	patients	patient	NOUN
ajmsi-1760	28	51	with	with	ADP
ajmsi-1760	28	52	such	such	ADJ
ajmsi-1760	28	53	comorbidities	comorbiditie	NOUN
ajmsi-1760	28	54	(	(	PUNCT
ajmsi-1760	28	55	ikwuka	ikwuka	NOUN
ajmsi-1760	28	56	,	,	PUNCT
ajmsi-1760	28	57	2017b	2017b	NUM
ajmsi-1760	28	58	;	;	PUNCT
ajmsi-1760	28	59	ikwuka	ikwuka	PROPN
ajmsi-1760	28	60	,	,	PUNCT
ajmsi-1760	28	61	2018a	2018a	NUM
ajmsi-1760	28	62	;	;	PUNCT
ajmsi-1760	28	63	ikwuka	ikwuka	PROPN
ajmsi-1760	28	64	,	,	PUNCT
ajmsi-1760	28	65	2018b	2018b	NUM
ajmsi-1760	28	66	;	;	PUNCT
ajmsi-1760	28	67	ikwuka	ikwuka	PROPN
ajmsi-1760	28	68	,	,	PUNCT
ajmsi-1760	28	69	2018c	2018c	NUM
ajmsi-1760	28	70	;	;	PUNCT
ajmsi-1760	28	71	ikwuka	ikwuka	PROPN
ajmsi-1760	28	72	,	,	PUNCT
ajmsi-1760	28	73	2019b	2019b	NUM
ajmsi-1760	28	74	;	;	PUNCT
ajmsi-1760	28	75	ikwuka	ikwuka	X
ajmsi-1760	28	76	,	,	PUNCT
ajmsi-1760	28	77	2021	2021	NUM
ajmsi-1760	28	78	;	;	PUNCT
ajmsi-1760	28	79	virstyuk	virstyuk	NOUN
ajmsi-1760	28	80	,	,	PUNCT
ajmsi-1760	28	81	2018b	2018b	NUM
ajmsi-1760	28	82	;	;	PUNCT
ajmsi-1760	28	83	virstyuk	virstyuk	NOUN
ajmsi-1760	28	84	,	,	PUNCT
ajmsi-1760	28	85	2018c	2018c	NUM
ajmsi-1760	28	86	;	;	PUNCT
ajmsi-1760	28	87	virstyuk	virstyuk	NOUN
ajmsi-1760	28	88	,	,	PUNCT
ajmsi-1760	28	89	2017b	2017b	NUM
ajmsi-1760	28	90	)	)	PUNCT
ajmsi-1760	28	91	,	,	PUNCT
ajmsi-1760	28	92	pa	pa	PROPN
ajmsi-1760	28	93	ge	ge	PROPN
ajmsi-1760	28	94	45	45	NUM
ajmsi-1760	28	95	https://journals.e-palli.com/home/index.php/ajmsi	https://journals.e-palli.com/home/index.php/ajmsi	PROPN
ajmsi-1760	28	96	am	be	AUX
ajmsi-1760	28	97	.	.	PUNCT
ajmsi-1760	29	1	j.	j.	PROPN
ajmsi-1760	29	2	med	med	PROPN
ajmsi-1760	29	3	.	.	PUNCT
ajmsi-1760	30	1	sci	sci	PROPN
ajmsi-1760	30	2	.	.	PUNCT
ajmsi-1760	30	3	innov	innov	PROPN
ajmsi-1760	30	4	.	.	PUNCT
ajmsi-1760	31	1	2(2	2(2	NUM
ajmsi-1760	31	2	)	)	PUNCT
ajmsi-1760	31	3	44	44	NUM
ajmsi-1760	31	4	-	-	SYM
ajmsi-1760	31	5	56	56	NUM
ajmsi-1760	31	6	,	,	PUNCT
ajmsi-1760	31	7	2023	2023	NUM
ajmsi-1760	31	8	thereby	thereby	ADV
ajmsi-1760	31	9	reducing	reduce	VERB
ajmsi-1760	31	10	kidney	kidney	NOUN
ajmsi-1760	31	11	damage	damage	NOUN
ajmsi-1760	31	12	,	,	PUNCT
ajmsi-1760	31	13	improve	improve	VERB
ajmsi-1760	31	14	kidney	kidney	NOUN
ajmsi-1760	31	15	functions	function	NOUN
ajmsi-1760	31	16	,	,	PUNCT
ajmsi-1760	31	17	and	and	CCONJ
ajmsi-1760	31	18	reduce	reduce	VERB
ajmsi-1760	31	19	anemia	anemia	NOUN
ajmsi-1760	31	20	.	.	PUNCT
ajmsi-1760	32	1	when	when	SCONJ
ajmsi-1760	32	2	hemoglobin	hemoglobin	PROPN
ajmsi-1760	32	3	s	s	PROPN
ajmsi-1760	32	4	encounters	encounter	VERB
ajmsi-1760	32	5	low	low	ADJ
ajmsi-1760	32	6	oxygen	oxygen	NOUN
ajmsi-1760	32	7	levels	level	NOUN
ajmsi-1760	32	8	,	,	PUNCT
ajmsi-1760	32	9	it	it	PRON
ajmsi-1760	32	10	forms	form	VERB
ajmsi-1760	32	11	long	long	ADJ
ajmsi-1760	32	12	crystals	crystal	NOUN
ajmsi-1760	32	13	(	(	PUNCT
ajmsi-1760	32	14	sometimes	sometimes	ADV
ajmsi-1760	32	15	15	15	NUM
ajmsi-1760	32	16	micrometers	micrometer	NOUN
ajmsi-1760	32	17	in	in	ADP
ajmsi-1760	32	18	length	length	NOUN
ajmsi-1760	32	19	)	)	PUNCT
ajmsi-1760	32	20	within	within	ADP
ajmsi-1760	32	21	rbcs	rbc	NOUN
ajmsi-1760	32	22	,	,	PUNCT
ajmsi-1760	32	23	impeding	impede	VERB
ajmsi-1760	32	24	their	their	PRON
ajmsi-1760	32	25	flow	flow	NOUN
ajmsi-1760	32	26	through	through	ADP
ajmsi-1760	32	27	narrow	narrow	ADJ
ajmsi-1760	32	28	capillaries	capillary	NOUN
ajmsi-1760	32	29	.	.	PUNCT
ajmsi-1760	33	1	the	the	DET
ajmsi-1760	33	2	pointed	pointed	ADJ
ajmsi-1760	33	3	ends	end	NOUN
ajmsi-1760	33	4	of	of	ADP
ajmsi-1760	33	5	these	these	DET
ajmsi-1760	33	6	crystals	crystal	NOUN
ajmsi-1760	33	7	can	can	AUX
ajmsi-1760	33	8	rupture	rupture	VERB
ajmsi-1760	33	9	the	the	DET
ajmsi-1760	33	10	plasmalemma	plasmalemma	PROPN
ajmsi-1760	33	11	leading	lead	VERB
ajmsi-1760	33	12	to	to	ADP
ajmsi-1760	33	13	sickle	sickle	PROPN
ajmsi-1760	33	14	cell	cell	NOUN
ajmsi-1760	33	15	anemia	anemia	NOUN
ajmsi-1760	33	16	(	(	PUNCT
ajmsi-1760	33	17	hall	hall	NOUN
ajmsi-1760	33	18	,	,	PUNCT
ajmsi-1760	33	19	2020	2020	NUM
ajmsi-1760	33	20	)	)	PUNCT
ajmsi-1760	33	21	.	.	PUNCT
ajmsi-1760	34	1	major	major	ADJ
ajmsi-1760	34	2	free	free	ADJ
ajmsi-1760	34	3	radicals	radical	NOUN
ajmsi-1760	34	4	that	that	PRON
ajmsi-1760	34	5	are	be	AUX
ajmsi-1760	34	6	of	of	ADP
ajmsi-1760	34	7	physiological	physiological	ADJ
ajmsi-1760	34	8	significance	significance	NOUN
ajmsi-1760	34	9	are	be	AUX
ajmsi-1760	34	10	superoxide	superoxide	NOUN
ajmsi-1760	34	11	anion	anion	NOUN
ajmsi-1760	34	12	,	,	PUNCT
ajmsi-1760	34	13	hydroxyl	hydroxyl	NOUN
ajmsi-1760	34	14	radical	radical	NOUN
ajmsi-1760	34	15	,	,	PUNCT
ajmsi-1760	34	16	and	and	CCONJ
ajmsi-1760	34	17	hydroperoxyl	hydroperoxyl	PROPN
ajmsi-1760	34	18	radical	radical	NOUN
ajmsi-1760	34	19	,	,	PUNCT
ajmsi-1760	34	20	while	while	SCONJ
ajmsi-1760	34	21	non	non	ADJ
ajmsi-1760	34	22	-	-	ADJ
ajmsi-1760	34	23	radical	radical	ADJ
ajmsi-1760	34	24	is	be	AUX
ajmsi-1760	34	25	hydrogen	hydrogen	NOUN
ajmsi-1760	34	26	peroxide	peroxide	NOUN
ajmsi-1760	34	27	(	(	PUNCT
ajmsi-1760	34	28	ikwuka	ikwuka	NOUN
ajmsi-1760	34	29	,	,	PUNCT
ajmsi-1760	34	30	2023c	2023c	NUM
ajmsi-1760	34	31	)	)	PUNCT
ajmsi-1760	34	32	.	.	PUNCT
ajmsi-1760	35	1	rauwolfia	rauwolfia	PROPN
ajmsi-1760	35	2	vomitoria	vomitoria	PROPN
ajmsi-1760	35	3	has	have	VERB
ajmsi-1760	35	4	a	a	DET
ajmsi-1760	35	5	neuroprotective	neuroprotective	ADJ
ajmsi-1760	35	6	ability	ability	NOUN
ajmsi-1760	35	7	at	at	SCONJ
ajmsi-1760	35	8	it	it	PRON
ajmsi-1760	35	9	elevates	elevate	VERB
ajmsi-1760	35	10	antioxidants	antioxidant	NOUN
ajmsi-1760	35	11	and	and	CCONJ
ajmsi-1760	35	12	suppresses	suppress	VERB
ajmsi-1760	35	13	lipid	lipid	NOUN
ajmsi-1760	35	14	peroxidation	peroxidation	NOUN
ajmsi-1760	35	15	(	(	PUNCT
ajmsi-1760	35	16	ekechi	ekechi	NOUN
ajmsi-1760	35	17	,	,	PUNCT
ajmsi-1760	35	18	2023	2023	NUM
ajmsi-1760	35	19	)	)	PUNCT
ajmsi-1760	35	20	.	.	PUNCT
ajmsi-1760	36	1	it	it	PRON
ajmsi-1760	36	2	is	be	AUX
ajmsi-1760	36	3	noteworthy	noteworthy	ADJ
ajmsi-1760	36	4	that	that	SCONJ
ajmsi-1760	36	5	nearly	nearly	ADV
ajmsi-1760	36	6	two	two	NUM
ajmsi-1760	36	7	-	-	PUNCT
ajmsi-1760	36	8	thirds	third	NOUN
ajmsi-1760	36	9	of	of	ADP
ajmsi-1760	36	10	infants	infant	NOUN
ajmsi-1760	36	11	worldwide	worldwide	ADV
ajmsi-1760	36	12	with	with	ADP
ajmsi-1760	36	13	hbss	hbss	NOUN
ajmsi-1760	36	14	or	or	CCONJ
ajmsi-1760	36	15	scd	scd	NOUN
ajmsi-1760	36	16	are	be	AUX
ajmsi-1760	36	17	born	bear	VERB
ajmsi-1760	36	18	in	in	ADP
ajmsi-1760	36	19	nigeria	nigeria	PROPN
ajmsi-1760	36	20	,	,	PUNCT
ajmsi-1760	36	21	the	the	DET
ajmsi-1760	36	22	republic	republic	NOUN
ajmsi-1760	36	23	of	of	ADP
ajmsi-1760	36	24	congo	congo	PROPN
ajmsi-1760	36	25	,	,	PUNCT
ajmsi-1760	36	26	or	or	CCONJ
ajmsi-1760	36	27	india	india	PROPN
ajmsi-1760	36	28	,	,	PUNCT
ajmsi-1760	36	29	where	where	SCONJ
ajmsi-1760	36	30	the	the	DET
ajmsi-1760	36	31	childhood	childhood	NOUN
ajmsi-1760	36	32	mortality	mortality	NOUN
ajmsi-1760	36	33	rate	rate	NOUN
ajmsi-1760	36	34	associated	associate	VERB
ajmsi-1760	36	35	with	with	ADP
ajmsi-1760	36	36	scd	scd	PROPN
ajmsi-1760	36	37	remains	remain	VERB
ajmsi-1760	36	38	alarmingly	alarmingly	ADV
ajmsi-1760	36	39	high	high	ADJ
ajmsi-1760	36	40	(	(	PUNCT
ajmsi-1760	36	41	piel	piel	NOUN
ajmsi-1760	36	42	,	,	PUNCT
ajmsi-1760	36	43	2013	2013	NUM
ajmsi-1760	36	44	)	)	PUNCT
ajmsi-1760	36	45	.	.	PUNCT
ajmsi-1760	37	1	symptoms	symptom	NOUN
ajmsi-1760	37	2	and	and	CCONJ
ajmsi-1760	37	3	complications	complication	NOUN
ajmsi-1760	37	4	of	of	ADP
ajmsi-1760	37	5	scd	scd	NOUN
ajmsi-1760	37	6	typically	typically	ADV
ajmsi-1760	37	7	manifest	manifest	VERB
ajmsi-1760	37	8	around	around	ADP
ajmsi-1760	37	9	5	5	NUM
ajmsi-1760	37	10	to	to	PART
ajmsi-1760	37	11	6	6	NUM
ajmsi-1760	37	12	months	month	NOUN
ajmsi-1760	37	13	of	of	ADP
ajmsi-1760	37	14	age	age	NOUN
ajmsi-1760	37	15	when	when	SCONJ
ajmsi-1760	37	16	fetal	fetal	ADJ
ajmsi-1760	37	17	hemoglobin	hemoglobin	NOUN
ajmsi-1760	37	18	(	(	PUNCT
ajmsi-1760	37	19	hbf	hbf	PROPN
ajmsi-1760	37	20	)	)	PUNCT
ajmsi-1760	37	21	synthesis	synthesis	NOUN
ajmsi-1760	37	22	significantly	significantly	ADV
ajmsi-1760	37	23	declines	decline	VERB
ajmsi-1760	37	24	.	.	PUNCT
ajmsi-1760	38	1	these	these	DET
ajmsi-1760	38	2	symptoms	symptom	NOUN
ajmsi-1760	38	3	include	include	VERB
ajmsi-1760	38	4	severe	severe	ADJ
ajmsi-1760	38	5	anemia	anemia	NOUN
ajmsi-1760	38	6	,	,	PUNCT
ajmsi-1760	38	7	episodes	episode	NOUN
ajmsi-1760	38	8	of	of	ADP
ajmsi-1760	38	9	pain	pain	NOUN
ajmsi-1760	38	10	(	(	PUNCT
ajmsi-1760	38	11	referred	refer	VERB
ajmsi-1760	38	12	to	to	ADP
ajmsi-1760	38	13	as	as	ADP
ajmsi-1760	38	14	sickle	sickle	NOUN
ajmsi-1760	38	15	cell	cell	NOUN
ajmsi-1760	38	16	crisis	crisis	NOUN
ajmsi-1760	38	17	)	)	PUNCT
ajmsi-1760	38	18	,	,	PUNCT
ajmsi-1760	38	19	swelling	swell	VERB
ajmsi-1760	38	20	in	in	ADP
ajmsi-1760	38	21	the	the	DET
ajmsi-1760	38	22	hands	hand	NOUN
ajmsi-1760	38	23	and	and	CCONJ
ajmsi-1760	38	24	feet	foot	NOUN
ajmsi-1760	38	25	,	,	PUNCT
ajmsi-1760	38	26	and	and	CCONJ
ajmsi-1760	38	27	potential	potential	ADJ
ajmsi-1760	38	28	complications	complication	NOUN
ajmsi-1760	38	29	such	such	ADJ
ajmsi-1760	38	30	as	as	ADP
ajmsi-1760	38	31	bacterial	bacterial	ADJ
ajmsi-1760	38	32	infections	infection	NOUN
ajmsi-1760	38	33	and	and	CCONJ
ajmsi-1760	38	34	stroke	stroke	NOUN
ajmsi-1760	38	35	(	(	PUNCT
ajmsi-1760	38	36	frangoul	frangoul	ADJ
ajmsi-1760	38	37	,	,	PUNCT
ajmsi-1760	38	38	2021	2021	NUM
ajmsi-1760	38	39	;	;	PUNCT
ajmsi-1760	38	40	hall	hall	NOUN
ajmsi-1760	38	41	,	,	PUNCT
ajmsi-1760	38	42	2020	2020	NUM
ajmsi-1760	38	43	)	)	PUNCT
ajmsi-1760	38	44	.	.	PUNCT
ajmsi-1760	39	1	long	long	ADJ
ajmsi-1760	39	2	-	-	PUNCT
ajmsi-1760	39	3	term	term	NOUN
ajmsi-1760	39	4	pain	pain	NOUN
ajmsi-1760	39	5	can	can	AUX
ajmsi-1760	39	6	develop	develop	VERB
ajmsi-1760	39	7	as	as	SCONJ
ajmsi-1760	39	8	individuals	individual	NOUN
ajmsi-1760	39	9	grow	grow	VERB
ajmsi-1760	39	10	older	old	ADJ
ajmsi-1760	39	11	,	,	PUNCT
ajmsi-1760	39	12	and	and	CCONJ
ajmsi-1760	39	13	the	the	DET
ajmsi-1760	39	14	average	average	ADJ
ajmsi-1760	39	15	life	life	NOUN
ajmsi-1760	39	16	expectancy	expectancy	NOUN
ajmsi-1760	39	17	in	in	ADP
ajmsi-1760	39	18	developed	develop	VERB
ajmsi-1760	39	19	countries	country	NOUN
ajmsi-1760	39	20	ranges	range	VERB
ajmsi-1760	39	21	from	from	ADP
ajmsi-1760	39	22	40	40	NUM
ajmsi-1760	39	23	to	to	PART
ajmsi-1760	39	24	60	60	NUM
ajmsi-1760	39	25	years	year	NOUN
ajmsi-1760	39	26	(	(	PUNCT
ajmsi-1760	39	27	national	national	ADJ
ajmsi-1760	39	28	heart	heart	NOUN
ajmsi-1760	39	29	,	,	PUNCT
ajmsi-1760	39	30	lung	lung	NOUN
ajmsi-1760	39	31	,	,	PUNCT
ajmsi-1760	39	32	and	and	CCONJ
ajmsi-1760	39	33	blood	blood	NOUN
ajmsi-1760	39	34	institute	institute	NOUN
ajmsi-1760	39	35	,	,	PUNCT
ajmsi-1760	39	36	2015	2015	NUM
ajmsi-1760	39	37	)	)	PUNCT
ajmsi-1760	39	38	.	.	PUNCT
ajmsi-1760	40	1	newborn	newborn	ADJ
ajmsi-1760	40	2	screening	screening	NOUN
ajmsi-1760	40	3	is	be	AUX
ajmsi-1760	40	4	the	the	DET
ajmsi-1760	40	5	common	common	ADJ
ajmsi-1760	40	6	diagnostic	diagnostic	ADJ
ajmsi-1760	40	7	approach	approach	NOUN
ajmsi-1760	40	8	for	for	ADP
ajmsi-1760	40	9	identifying	identify	VERB
ajmsi-1760	40	10	hbss	hbss	NOUN
ajmsi-1760	40	11	,	,	PUNCT
ajmsi-1760	40	12	and	and	CCONJ
ajmsi-1760	40	13	treatment	treatment	NOUN
ajmsi-1760	40	14	options	option	NOUN
ajmsi-1760	40	15	include	include	VERB
ajmsi-1760	40	16	penicillin	penicillin	NOUN
ajmsi-1760	40	17	(	(	PUNCT
ajmsi-1760	40	18	essential	essential	ADJ
ajmsi-1760	40	19	for	for	ADP
ajmsi-1760	40	20	children	child	NOUN
ajmsi-1760	40	21	under	under	ADP
ajmsi-1760	40	22	five	five	NUM
ajmsi-1760	40	23	years	year	NOUN
ajmsi-1760	40	24	with	with	ADP
ajmsi-1760	40	25	immature	immature	ADJ
ajmsi-1760	40	26	immune	immune	ADJ
ajmsi-1760	40	27	systems	system	NOUN
ajmsi-1760	40	28	)	)	PUNCT
ajmsi-1760	40	29	,	,	PUNCT
ajmsi-1760	40	30	folic	folic	ADJ
ajmsi-1760	40	31	acid	acid	NOUN
ajmsi-1760	40	32	supplementation	supplementation	NOUN
ajmsi-1760	40	33	,	,	PUNCT
ajmsi-1760	40	34	blood	blood	NOUN
ajmsi-1760	40	35	transfusions	transfusion	NOUN
ajmsi-1760	40	36	,	,	PUNCT
ajmsi-1760	40	37	vaccinations	vaccination	NOUN
ajmsi-1760	40	38	against	against	ADP
ajmsi-1760	40	39	encapsulated	encapsulate	VERB
ajmsi-1760	40	40	organisms	organism	NOUN
ajmsi-1760	40	41	,	,	PUNCT
ajmsi-1760	41	1	transcranial	transcranial	ADJ
ajmsi-1760	41	2	doppler	doppler	NOUN
ajmsi-1760	41	3	(	(	PUNCT
ajmsi-1760	41	4	tcd	tcd	NOUN
ajmsi-1760	41	5	)	)	PUNCT
ajmsi-1760	41	6	screening	screen	VERB
ajmsi-1760	41	7	to	to	PART
ajmsi-1760	41	8	identify	identify	VERB
ajmsi-1760	41	9	stroke	stroke	NOUN
ajmsi-1760	41	10	risk	risk	NOUN
ajmsi-1760	41	11	in	in	ADP
ajmsi-1760	41	12	children	child	NOUN
ajmsi-1760	41	13	(	(	PUNCT
ajmsi-1760	41	14	followed	follow	VERB
ajmsi-1760	41	15	by	by	ADP
ajmsi-1760	41	16	blood	blood	NOUN
ajmsi-1760	41	17	transfusions	transfusion	NOUN
ajmsi-1760	41	18	,	,	PUNCT
ajmsi-1760	41	19	if	if	SCONJ
ajmsi-1760	41	20	necessary	necessary	ADJ
ajmsi-1760	41	21	)	)	PUNCT
ajmsi-1760	41	22	,	,	PUNCT
ajmsi-1760	41	23	pain	pain	NOUN
ajmsi-1760	41	24	management	management	NOUN
ajmsi-1760	41	25	,	,	PUNCT
ajmsi-1760	41	26	hydroxyurea	hydroxyurea	PROPN
ajmsi-1760	41	27	,	,	PUNCT
ajmsi-1760	41	28	and	and	CCONJ
ajmsi-1760	41	29	intensive	intensive	ADJ
ajmsi-1760	41	30	hospital	hospital	NOUN
ajmsi-1760	41	31	-	-	PUNCT
ajmsi-1760	41	32	based	base	VERB
ajmsi-1760	41	33	care	care	NOUN
ajmsi-1760	41	34	(	(	PUNCT
ajmsi-1760	41	35	adams	adams	PROPN
ajmsi-1760	41	36	,	,	PUNCT
ajmsi-1760	41	37	1998	1998	NUM
ajmsi-1760	41	38	;	;	PUNCT
ajmsi-1760	41	39	gaston	gaston	PROPN
ajmsi-1760	41	40	,	,	PUNCT
ajmsi-1760	41	41	1986	1986	NUM
ajmsi-1760	41	42	;	;	PUNCT
ajmsi-1760	41	43	thornburg	thornburg	NUM
ajmsi-1760	41	44	,	,	PUNCT
ajmsi-1760	41	45	2012	2012	NUM
ajmsi-1760	41	46	;	;	PUNCT
ajmsi-1760	41	47	who	who	PRON
ajmsi-1760	41	48	,	,	PUNCT
ajmsi-1760	41	49	2011	2011	NUM
ajmsi-1760	41	50	)	)	PUNCT
ajmsi-1760	41	51	.	.	PUNCT
ajmsi-1760	42	1	other	other	ADJ
ajmsi-1760	42	2	diagnostic	diagnostic	ADJ
ajmsi-1760	42	3	tests	test	NOUN
ajmsi-1760	42	4	for	for	ADP
ajmsi-1760	42	5	scd	scd	NOUN
ajmsi-1760	42	6	include	include	VERB
ajmsi-1760	42	7	sickling	sickle	VERB
ajmsi-1760	42	8	of	of	ADP
ajmsi-1760	42	9	the	the	DET
ajmsi-1760	42	10	red	red	ADJ
ajmsi-1760	42	11	blood	blood	NOUN
ajmsi-1760	42	12	cells	cell	NOUN
ajmsi-1760	42	13	on	on	ADP
ajmsi-1760	42	14	a	a	DET
ajmsi-1760	42	15	blood	blood	NOUN
ajmsi-1760	42	16	film	film	NOUN
ajmsi-1760	42	17	which	which	PRON
ajmsi-1760	42	18	is	be	AUX
ajmsi-1760	42	19	induced	induce	VERB
ajmsi-1760	42	20	by	by	ADP
ajmsi-1760	42	21	the	the	DET
ajmsi-1760	42	22	addition	addition	NOUN
ajmsi-1760	42	23	of	of	ADP
ajmsi-1760	42	24	sodium	sodium	NOUN
ajmsi-1760	42	25	metabisulfite	metabisulfite	NOUN
ajmsi-1760	42	26	;	;	PUNCT
ajmsi-1760	42	27	and	and	CCONJ
ajmsi-1760	42	28	another	another	DET
ajmsi-1760	42	29	test	test	NOUN
ajmsi-1760	42	30	referred	refer	VERB
ajmsi-1760	42	31	to	to	ADP
ajmsi-1760	42	32	as	as	ADP
ajmsi-1760	42	33	hemoglobin	hemoglobin	NOUN
ajmsi-1760	42	34	electrophoresis	electrophoresis	NOUN
ajmsi-1760	42	35	which	which	PRON
ajmsi-1760	42	36	detects	detect	NOUN
ajmsi-1760	42	37	abnormal	abnormal	ADJ
ajmsi-1760	42	38	hemoglobin	hemoglobin	NOUN
ajmsi-1760	42	39	forms	form	NOUN
ajmsi-1760	42	40	(	(	PUNCT
ajmsi-1760	42	41	ikwuka	ikwuka	ADJ
ajmsi-1760	42	42	,	,	PUNCT
ajmsi-1760	42	43	2023b	2023b	NUM
ajmsi-1760	42	44	)	)	PUNCT
ajmsi-1760	42	45	.	.	PUNCT
ajmsi-1760	43	1	however	however	ADV
ajmsi-1760	43	2	,	,	PUNCT
ajmsi-1760	43	3	despite	despite	SCONJ
ajmsi-1760	43	4	the	the	DET
ajmsi-1760	43	5	significant	significant	ADJ
ajmsi-1760	43	6	need	need	NOUN
ajmsi-1760	43	7	for	for	ADP
ajmsi-1760	43	8	effective	effective	ADJ
ajmsi-1760	43	9	treatment	treatment	NOUN
ajmsi-1760	43	10	options	option	NOUN
ajmsi-1760	43	11	for	for	ADP
ajmsi-1760	43	12	scd	scd	NOUN
ajmsi-1760	43	13	patients	patient	NOUN
ajmsi-1760	43	14	,	,	PUNCT
ajmsi-1760	43	15	current	current	ADJ
ajmsi-1760	43	16	treatments	treatment	NOUN
ajmsi-1760	43	17	both	both	CCONJ
ajmsi-1760	43	18	traditional	traditional	ADJ
ajmsi-1760	43	19	and	and	CCONJ
ajmsi-1760	43	20	newly	newly	ADV
ajmsi-1760	43	21	developed	develop	VERB
ajmsi-1760	43	22	,	,	PUNCT
ajmsi-1760	43	23	only	only	ADV
ajmsi-1760	43	24	ameliorate	ameliorate	VERB
ajmsi-1760	43	25	acute	acute	ADJ
ajmsi-1760	43	26	and	and	CCONJ
ajmsi-1760	43	27	chronic	chronic	ADJ
ajmsi-1760	43	28	scd	scd	NOUN
ajmsi-1760	43	29	manifestations	manifestation	NOUN
ajmsi-1760	43	30	without	without	ADP
ajmsi-1760	43	31	addressing	address	VERB
ajmsi-1760	43	32	the	the	DET
ajmsi-1760	43	33	underlying	underlie	VERB
ajmsi-1760	43	34	cause	cause	NOUN
ajmsi-1760	43	35	.	.	PUNCT
ajmsi-1760	44	1	hydroxyurea	hydroxyurea	PROPN
ajmsi-1760	44	2	and	and	CCONJ
ajmsi-1760	44	3	long	long	ADJ
ajmsi-1760	44	4	-	-	PUNCT
ajmsi-1760	44	5	term	term	NOUN
ajmsi-1760	44	6	blood	blood	NOUN
ajmsi-1760	44	7	transfusions	transfusion	NOUN
ajmsi-1760	44	8	aim	aim	VERB
ajmsi-1760	44	9	to	to	PART
ajmsi-1760	44	10	prevent	prevent	VERB
ajmsi-1760	44	11	and	and	CCONJ
ajmsi-1760	44	12	treat	treat	VERB
ajmsi-1760	44	13	complications	complication	NOUN
ajmsi-1760	44	14	associated	associate	VERB
ajmsi-1760	44	15	with	with	ADP
ajmsi-1760	44	16	scd	scd	PROPN
ajmsi-1760	44	17	.	.	PUNCT
ajmsi-1760	45	1	the	the	DET
ajmsi-1760	45	2	recently	recently	ADV
ajmsi-1760	45	3	approved	approve	VERB
ajmsi-1760	45	4	crizanlizumab	crizanlizumab	NOUN
ajmsi-1760	45	5	(	(	PUNCT
ajmsi-1760	45	6	ataga	ataga	NOUN
ajmsi-1760	45	7	,	,	PUNCT
ajmsi-1760	45	8	2017	2017	NUM
ajmsi-1760	45	9	)	)	PUNCT
ajmsi-1760	45	10	has	have	AUX
ajmsi-1760	45	11	shown	show	VERB
ajmsi-1760	45	12	a	a	DET
ajmsi-1760	45	13	reduced	reduced	ADJ
ajmsi-1760	45	14	incidence	incidence	NOUN
ajmsi-1760	45	15	of	of	ADP
ajmsi-1760	45	16	cellular	cellular	ADJ
ajmsi-1760	45	17	adhesion	adhesion	NOUN
ajmsi-1760	45	18	and	and	CCONJ
ajmsi-1760	45	19	vaso	vaso	NOUN
ajmsi-1760	45	20	-	-	PUNCT
ajmsi-1760	45	21	occlusive	occlusive	NOUN
ajmsi-1760	45	22	crisis	crisis	NOUN
ajmsi-1760	45	23	in	in	ADP
ajmsi-1760	45	24	scd	scd	NOUN
ajmsi-1760	45	25	patients	patient	NOUN
ajmsi-1760	45	26	,	,	PUNCT
ajmsi-1760	45	27	but	but	CCONJ
ajmsi-1760	45	28	it	it	PRON
ajmsi-1760	45	29	does	do	AUX
ajmsi-1760	45	30	not	not	PART
ajmsi-1760	45	31	target	target	VERB
ajmsi-1760	45	32	the	the	DET
ajmsi-1760	45	33	root	root	NOUN
ajmsi-1760	45	34	cause	cause	NOUN
ajmsi-1760	45	35	of	of	ADP
ajmsi-1760	45	36	the	the	DET
ajmsi-1760	45	37	disease	disease	NOUN
ajmsi-1760	45	38	or	or	CCONJ
ajmsi-1760	45	39	fully	fully	ADV
ajmsi-1760	45	40	alleviate	alleviate	VERB
ajmsi-1760	45	41	its	its	PRON
ajmsi-1760	45	42	manifestations	manifestation	NOUN
ajmsi-1760	45	43	(	(	PUNCT
ajmsi-1760	45	44	frangoul	frangoul	ADJ
ajmsi-1760	45	45	,	,	PUNCT
ajmsi-1760	45	46	2021	2021	NUM
ajmsi-1760	45	47	)	)	PUNCT
ajmsi-1760	45	48	.	.	PUNCT
ajmsi-1760	46	1	allogeneic	allogeneic	ADJ
ajmsi-1760	46	2	hematopoietic	hematopoietic	ADJ
ajmsi-1760	46	3	stem	stem	NOUN
ajmsi-1760	46	4	cell	cell	NOUN
ajmsi-1760	46	5	transplantation	transplantation	NOUN
ajmsi-1760	46	6	(	(	PUNCT
ajmsi-1760	46	7	hsct	hsct	PROPN
ajmsi-1760	46	8	)	)	PUNCT
ajmsi-1760	46	9	remains	remain	VERB
ajmsi-1760	46	10	the	the	DET
ajmsi-1760	46	11	sole	sole	ADJ
ajmsi-1760	46	12	curative	curative	ADJ
ajmsi-1760	46	13	option	option	NOUN
ajmsi-1760	46	14	for	for	ADP
ajmsi-1760	46	15	scd	scd	NOUN
ajmsi-1760	46	16	,	,	PUNCT
ajmsi-1760	46	17	yet	yet	ADV
ajmsi-1760	46	18	less	less	ADJ
ajmsi-1760	46	19	than	than	ADP
ajmsi-1760	46	20	20	20	NUM
ajmsi-1760	46	21	%	%	NOUN
ajmsi-1760	46	22	of	of	ADP
ajmsi-1760	46	23	eligible	eligible	ADJ
ajmsi-1760	46	24	patients	patient	NOUN
ajmsi-1760	46	25	have	have	VERB
ajmsi-1760	46	26	a	a	DET
ajmsi-1760	46	27	suitable	suitable	ADJ
ajmsi-1760	46	28	hla	hla	NOUN
ajmsi-1760	46	29	-	-	PUNCT
ajmsi-1760	46	30	matched	match	VERB
ajmsi-1760	46	31	donor	donor	NOUN
ajmsi-1760	46	32	(	(	PUNCT
ajmsi-1760	46	33	baronciani	baronciani	NOUN
ajmsi-1760	46	34	,	,	PUNCT
ajmsi-1760	46	35	2016	2016	NUM
ajmsi-1760	46	36	;	;	PUNCT
ajmsi-1760	46	37	eapen	eapen	ADJ
ajmsi-1760	46	38	,	,	PUNCT
ajmsi-1760	46	39	2019	2019	NUM
ajmsi-1760	46	40	;	;	PUNCT
ajmsi-1760	46	41	gluckman	gluckman	NOUN
ajmsi-1760	46	42	,	,	PUNCT
ajmsi-1760	46	43	2017	2017	NUM
ajmsi-1760	46	44	)	)	PUNCT
ajmsi-1760	46	45	.	.	PUNCT
ajmsi-1760	47	1	further	further	ADJ
ajmsi-1760	47	2	advances	advance	NOUN
ajmsi-1760	47	3	in	in	ADP
ajmsi-1760	47	4	the	the	DET
ajmsi-1760	47	5	understanding	understanding	NOUN
ajmsi-1760	47	6	of	of	ADP
ajmsi-1760	47	7	the	the	DET
ajmsi-1760	47	8	pathophysiology	pathophysiology	NOUN
ajmsi-1760	47	9	of	of	ADP
ajmsi-1760	47	10	scd	scd	PROPN
ajmsi-1760	47	11	contributed	contribute	VERB
ajmsi-1760	47	12	to	to	ADP
ajmsi-1760	47	13	the	the	DET
ajmsi-1760	47	14	development	development	NOUN
ajmsi-1760	47	15	of	of	ADP
ajmsi-1760	47	16	the	the	PRON
ajmsi-1760	47	17	exciting	exciting	ADJ
ajmsi-1760	47	18	and	and	CCONJ
ajmsi-1760	47	19	novel	novel	ADJ
ajmsi-1760	47	20	“	"	PUNCT
ajmsi-1760	47	21	clustered	cluster	VERB
ajmsi-1760	47	22	regularly	regularly	ADV
ajmsi-1760	47	23	interspaced	interspace	VERB
ajmsi-1760	47	24	short	short	ADJ
ajmsi-1760	47	25	palindromic	palindromic	ADJ
ajmsi-1760	47	26	repeats	repeat	NOUN
ajmsi-1760	47	27	(	(	PUNCT
ajmsi-1760	47	28	crispr)-associated	crispr)-associate	VERB
ajmsi-1760	47	29	protein	protein	NOUN
ajmsi-1760	47	30	9	9	NUM
ajmsi-1760	47	31	(	(	PUNCT
ajmsi-1760	47	32	crispr	crispr	NOUN
ajmsi-1760	47	33	-	-	PUNCT
ajmsi-1760	47	34	cas9	cas9	NOUN
ajmsi-1760	47	35	)	)	PUNCT
ajmsi-1760	47	36	”	"	PUNCT
ajmsi-1760	47	37	genomic	genomic	NOUN
ajmsi-1760	47	38	editing	editing	NOUN
ajmsi-1760	47	39	therapy	therapy	NOUN
ajmsi-1760	47	40	to	to	PART
ajmsi-1760	47	41	cure	cure	VERB
ajmsi-1760	47	42	the	the	DET
ajmsi-1760	47	43	disease	disease	NOUN
ajmsi-1760	47	44	and	and	CCONJ
ajmsi-1760	47	45	its	its	PRON
ajmsi-1760	47	46	complications	complication	NOUN
ajmsi-1760	47	47	.	.	PUNCT
ajmsi-1760	48	1	bacteriophages	bacteriophage	NOUN
ajmsi-1760	48	2	have	have	VERB
ajmsi-1760	48	3	the	the	DET
ajmsi-1760	48	4	ability	ability	NOUN
ajmsi-1760	48	5	to	to	PART
ajmsi-1760	48	6	infect	infect	VERB
ajmsi-1760	48	7	bacteria	bacteria	NOUN
ajmsi-1760	48	8	by	by	ADP
ajmsi-1760	48	9	implanting	implant	VERB
ajmsi-1760	48	10	its	its	PRON
ajmsi-1760	48	11	genetic	genetic	ADJ
ajmsi-1760	48	12	material	material	NOUN
ajmsi-1760	48	13	into	into	ADP
ajmsi-1760	48	14	the	the	DET
ajmsi-1760	48	15	bacterial	bacterial	ADJ
ajmsi-1760	48	16	genome	genome	NOUN
ajmsi-1760	48	17	(	(	PUNCT
ajmsi-1760	48	18	chaudhary	chaudhary	PROPN
ajmsi-1760	48	19	,	,	PUNCT
ajmsi-1760	48	20	2020	2020	NUM
ajmsi-1760	48	21	)	)	PUNCT
ajmsi-1760	48	22	.	.	PUNCT
ajmsi-1760	49	1	thereafter	thereafter	ADV
ajmsi-1760	49	2	,	,	PUNCT
ajmsi-1760	49	3	bacteria	bacteria	NOUN
ajmsi-1760	49	4	have	have	VERB
ajmsi-1760	49	5	a	a	DET
ajmsi-1760	49	6	natural	natural	ADJ
ajmsi-1760	49	7	defense	defense	NOUN
ajmsi-1760	49	8	mechanism	mechanism	NOUN
ajmsi-1760	49	9	against	against	ADP
ajmsi-1760	49	10	bacteriophages	bacteriophage	NOUN
ajmsi-1760	49	11	,	,	PUNCT
ajmsi-1760	49	12	whereby	whereby	SCONJ
ajmsi-1760	49	13	on	on	ADP
ajmsi-1760	49	14	the	the	DET
ajmsi-1760	49	15	first	first	ADJ
ajmsi-1760	49	16	exposure	exposure	NOUN
ajmsi-1760	49	17	to	to	ADP
ajmsi-1760	49	18	a	a	DET
ajmsi-1760	49	19	bacteriophage	bacteriophage	NOUN
ajmsi-1760	49	20	they	they	PRON
ajmsi-1760	49	21	produce	produce	VERB
ajmsi-1760	49	22	crispr	crispr	ADJ
ajmsi-1760	49	23	sequence	sequence	NOUN
ajmsi-1760	49	24	as	as	ADP
ajmsi-1760	49	25	a	a	DET
ajmsi-1760	49	26	form	form	NOUN
ajmsi-1760	49	27	of	of	ADP
ajmsi-1760	49	28	genetic	genetic	ADJ
ajmsi-1760	49	29	memory	memory	NOUN
ajmsi-1760	49	30	.	.	PUNCT
ajmsi-1760	50	1	crispr	crispr	ADJ
ajmsi-1760	50	2	sequence	sequence	NOUN
ajmsi-1760	50	3	is	be	AUX
ajmsi-1760	50	4	always	always	ADV
ajmsi-1760	50	5	found	find	VERB
ajmsi-1760	50	6	in	in	ADP
ajmsi-1760	50	7	association	association	NOUN
ajmsi-1760	50	8	with	with	ADP
ajmsi-1760	50	9	the	the	DET
ajmsi-1760	50	10	cas9	cas9	NOUN
ajmsi-1760	50	11	,	,	PUNCT
ajmsi-1760	50	12	a	a	DET
ajmsi-1760	50	13	nuclease	nuclease	NOUN
ajmsi-1760	50	14	that	that	PRON
ajmsi-1760	50	15	can	can	AUX
ajmsi-1760	50	16	cleave	cleave	VERB
ajmsi-1760	50	17	the	the	DET
ajmsi-1760	50	18	dna	dna	NOUN
ajmsi-1760	50	19	.	.	PUNCT
ajmsi-1760	51	1	in	in	ADP
ajmsi-1760	51	2	subsequent	subsequent	ADJ
ajmsi-1760	51	3	exposure	exposure	NOUN
ajmsi-1760	51	4	to	to	ADP
ajmsi-1760	51	5	a	a	DET
ajmsi-1760	51	6	similar	similar	ADJ
ajmsi-1760	51	7	bacteriophage	bacteriophage	NOUN
ajmsi-1760	51	8	,	,	PUNCT
ajmsi-1760	51	9	the	the	DET
ajmsi-1760	51	10	bacteria	bacteria	NOUN
ajmsi-1760	51	11	form	form	VERB
ajmsi-1760	51	12	guiderna	guiderna	NOUN
ajmsi-1760	51	13	from	from	ADP
ajmsi-1760	51	14	the	the	DET
ajmsi-1760	51	15	transcription	transcription	NOUN
ajmsi-1760	51	16	of	of	ADP
ajmsi-1760	51	17	the	the	DET
ajmsi-1760	51	18	crispr	crispr	ADJ
ajmsi-1760	51	19	sequence	sequence	NOUN
ajmsi-1760	51	20	.	.	PUNCT
ajmsi-1760	52	1	the	the	DET
ajmsi-1760	52	2	guiderna	guiderna	NOUN
ajmsi-1760	52	3	finds	find	VERB
ajmsi-1760	52	4	its	its	PRON
ajmsi-1760	52	5	target	target	NOUN
ajmsi-1760	52	6	in	in	ADP
ajmsi-1760	52	7	the	the	DET
ajmsi-1760	52	8	bacteriophage	bacteriophage	NOUN
ajmsi-1760	52	9	dna	dna	NOUN
ajmsi-1760	52	10	,	,	PUNCT
ajmsi-1760	52	11	while	while	SCONJ
ajmsi-1760	52	12	the	the	DET
ajmsi-1760	52	13	cas9	cas9	NOUN
ajmsi-1760	52	14	cleaves	cleave	VERB
ajmsi-1760	52	15	the	the	DET
ajmsi-1760	52	16	dna	dna	PROPN
ajmsi-1760	52	17	(	(	PUNCT
ajmsi-1760	52	18	chaudhary	chaudhary	PROPN
ajmsi-1760	52	19	,	,	PUNCT
ajmsi-1760	52	20	2020	2020	NUM
ajmsi-1760	52	21	)	)	PUNCT
ajmsi-1760	52	22	.	.	PUNCT
ajmsi-1760	53	1	the	the	DET
ajmsi-1760	53	2	advantage	advantage	NOUN
ajmsi-1760	53	3	of	of	ADP
ajmsi-1760	53	4	this	this	DET
ajmsi-1760	53	5	system	system	NOUN
ajmsi-1760	53	6	is	be	AUX
ajmsi-1760	53	7	that	that	SCONJ
ajmsi-1760	53	8	once	once	SCONJ
ajmsi-1760	53	9	the	the	DET
ajmsi-1760	53	10	crispr	crispr	ADJ
ajmsi-1760	53	11	system	system	NOUN
ajmsi-1760	53	12	has	have	AUX
ajmsi-1760	53	13	cleaved	cleave	VERB
ajmsi-1760	53	14	the	the	DET
ajmsi-1760	53	15	dna	dna	NOUN
ajmsi-1760	53	16	,	,	PUNCT
ajmsi-1760	53	17	a	a	DET
ajmsi-1760	53	18	dna	dna	NOUN
ajmsi-1760	53	19	template	template	NOUN
ajmsi-1760	53	20	carrying	carry	VERB
ajmsi-1760	53	21	the	the	DET
ajmsi-1760	53	22	desired	desire	VERB
ajmsi-1760	53	23	sequence	sequence	NOUN
ajmsi-1760	53	24	can	can	AUX
ajmsi-1760	53	25	join	join	VERB
ajmsi-1760	53	26	the	the	DET
ajmsi-1760	53	27	cleaved	cleaved	ADJ
ajmsi-1760	53	28	end	end	NOUN
ajmsi-1760	53	29	,	,	PUNCT
ajmsi-1760	53	30	thereby	thereby	ADV
ajmsi-1760	53	31	facilitating	facilitate	VERB
ajmsi-1760	53	32	recombination	recombination	NOUN
ajmsi-1760	53	33	and	and	CCONJ
ajmsi-1760	53	34	replacement	replacement	NOUN
ajmsi-1760	53	35	of	of	ADP
ajmsi-1760	53	36	the	the	DET
ajmsi-1760	53	37	original	original	ADJ
ajmsi-1760	53	38	sequence	sequence	NOUN
ajmsi-1760	53	39	with	with	ADP
ajmsi-1760	53	40	the	the	DET
ajmsi-1760	53	41	new	new	ADJ
ajmsi-1760	53	42	version	version	NOUN
ajmsi-1760	53	43	.	.	PUNCT
ajmsi-1760	54	1	the	the	DET
ajmsi-1760	54	2	crispr	crispr	ADJ
ajmsi-1760	54	3	-	-	PUNCT
ajmsi-1760	54	4	cas9	cas9	NOUN
ajmsi-1760	54	5	nuclease	nuclease	NOUN
ajmsi-1760	54	6	system	system	NOUN
ajmsi-1760	54	7	can	can	AUX
ajmsi-1760	54	8	be	be	AUX
ajmsi-1760	54	9	employed	employ	VERB
ajmsi-1760	54	10	in	in	ADP
ajmsi-1760	54	11	cultured	cultured	ADJ
ajmsi-1760	54	12	cells	cell	NOUN
ajmsi-1760	54	13	,	,	PUNCT
ajmsi-1760	54	14	including	include	VERB
ajmsi-1760	54	15	stem	stem	NOUN
ajmsi-1760	54	16	cells	cell	NOUN
ajmsi-1760	54	17	,	,	PUNCT
ajmsi-1760	54	18	as	as	ADV
ajmsi-1760	54	19	well	well	ADV
ajmsi-1760	54	20	as	as	ADP
ajmsi-1760	54	21	in	in	ADP
ajmsi-1760	54	22	fertilized	fertilized	ADJ
ajmsi-1760	54	23	eggs	egg	NOUN
ajmsi-1760	54	24	,	,	PUNCT
ajmsi-1760	54	25	enabling	enable	VERB
ajmsi-1760	54	26	the	the	DET
ajmsi-1760	54	27	generation	generation	NOUN
ajmsi-1760	54	28	of	of	ADP
ajmsi-1760	54	29	transgenic	transgenic	NOUN
ajmsi-1760	54	30	animals	animal	NOUN
ajmsi-1760	54	31	with	with	ADP
ajmsi-1760	54	32	targeted	target	VERB
ajmsi-1760	54	33	mutations	mutation	NOUN
ajmsi-1760	54	34	.	.	PUNCT
ajmsi-1760	55	1	this	this	DET
ajmsi-1760	55	2	genomic	genomic	NOUN
ajmsi-1760	55	3	editing	editing	NOUN
ajmsi-1760	55	4	technique	technique	NOUN
ajmsi-1760	55	5	has	have	AUX
ajmsi-1760	55	6	been	be	AUX
ajmsi-1760	55	7	extensively	extensively	ADV
ajmsi-1760	55	8	studied	study	VERB
ajmsi-1760	55	9	in	in	ADP
ajmsi-1760	55	10	various	various	ADJ
ajmsi-1760	55	11	organisms	organism	NOUN
ajmsi-1760	55	12	such	such	ADJ
ajmsi-1760	55	13	as	as	ADP
ajmsi-1760	55	14	yeast	yeast	NOUN
ajmsi-1760	55	15	,	,	PUNCT
ajmsi-1760	55	16	drosophila	drosophila	NOUN
ajmsi-1760	55	17	,	,	PUNCT
ajmsi-1760	55	18	zebrafish	zebrafish	ADJ
ajmsi-1760	55	19	,	,	PUNCT
ajmsi-1760	55	20	plants	plant	NOUN
ajmsi-1760	55	21	,	,	PUNCT
ajmsi-1760	55	22	monkeys	monkey	NOUN
ajmsi-1760	55	23	,	,	PUNCT
ajmsi-1760	55	24	and	and	CCONJ
ajmsi-1760	55	25	pigs	pig	NOUN
ajmsi-1760	55	26	,	,	PUNCT
ajmsi-1760	55	27	in	in	ADP
ajmsi-1760	55	28	addition	addition	NOUN
ajmsi-1760	55	29	to	to	ADP
ajmsi-1760	55	30	the	the	DET
ajmsi-1760	55	31	bacteria	bacteria	NOUN
ajmsi-1760	55	32	from	from	ADP
ajmsi-1760	55	33	which	which	PRON
ajmsi-1760	55	34	the	the	DET
ajmsi-1760	55	35	technique	technique	NOUN
ajmsi-1760	55	36	was	be	AUX
ajmsi-1760	55	37	originally	originally	ADV
ajmsi-1760	55	38	derived	derive	VERB
ajmsi-1760	55	39	from	from	ADP
ajmsi-1760	55	40	(	(	PUNCT
ajmsi-1760	55	41	wen	wen	PROPN
ajmsi-1760	55	42	,	,	PUNCT
ajmsi-1760	55	43	2017	2017	NUM
ajmsi-1760	55	44	)	)	PUNCT
ajmsi-1760	55	45	.	.	PUNCT
ajmsi-1760	56	1	in	in	ADP
ajmsi-1760	56	2	the	the	DET
ajmsi-1760	56	3	case	case	NOUN
ajmsi-1760	56	4	of	of	ADP
ajmsi-1760	56	5	scd	scd	PROPN
ajmsi-1760	56	6	,	,	PUNCT
ajmsi-1760	56	7	the	the	DET
ajmsi-1760	56	8	crispr	crispr	ADJ
ajmsi-1760	56	9	-	-	PUNCT
ajmsi-1760	56	10	cas9	cas9	NOUN
ajmsi-1760	56	11	nuclease	nuclease	NOUN
ajmsi-1760	56	12	system	system	NOUN
ajmsi-1760	56	13	is	be	AUX
ajmsi-1760	56	14	applied	apply	VERB
ajmsi-1760	56	15	to	to	ADP
ajmsi-1760	56	16	hematopoietic	hematopoietic	ADJ
ajmsi-1760	56	17	stem	stem	NOUN
ajmsi-1760	56	18	and	and	CCONJ
ajmsi-1760	56	19	progenitor	progenitor	NOUN
ajmsi-1760	56	20	cells	cell	NOUN
ajmsi-1760	56	21	(	(	PUNCT
ajmsi-1760	56	22	hspcs	hspc	NOUN
ajmsi-1760	56	23	)	)	PUNCT
ajmsi-1760	56	24	at	at	ADP
ajmsi-1760	56	25	the	the	DET
ajmsi-1760	56	26	erythroid	erythroid	ADJ
ajmsi-1760	56	27	-	-	PUNCT
ajmsi-1760	56	28	specific	specific	ADJ
ajmsi-1760	56	29	enhancer	enhancer	NOUN
ajmsi-1760	56	30	region	region	NOUN
ajmsi-1760	56	31	of	of	ADP
ajmsi-1760	56	32	the	the	DET
ajmsi-1760	56	33	bcl11a	bcl11a	NOUN
ajmsi-1760	56	34	locus	locus	NOUN
ajmsi-1760	56	35	on	on	ADP
ajmsi-1760	56	36	chromosome	chromosome	NOUN
ajmsi-1760	56	37	2	2	NUM
ajmsi-1760	56	38	(	(	PUNCT
ajmsi-1760	56	39	uda	uda	NOUN
ajmsi-1760	56	40	,	,	PUNCT
ajmsi-1760	56	41	2008	2008	NUM
ajmsi-1760	56	42	)	)	PUNCT
ajmsi-1760	56	43	.	.	PUNCT
ajmsi-1760	57	1	normally	normally	ADV
ajmsi-1760	57	2	,	,	PUNCT
ajmsi-1760	57	3	bcl11a	bcl11a	PRON
ajmsi-1760	57	4	encodes	encode	VERB
ajmsi-1760	57	5	a	a	DET
ajmsi-1760	57	6	transcription	transcription	NOUN
ajmsi-1760	57	7	factor	factor	NOUN
ajmsi-1760	57	8	that	that	PRON
ajmsi-1760	57	9	inhibits	inhibit	VERB
ajmsi-1760	57	10	hbf	hbf	PROPN
ajmsi-1760	57	11	synthesis	synthesis	NOUN
ajmsi-1760	57	12	.	.	PUNCT
ajmsi-1760	58	1	the	the	DET
ajmsi-1760	58	2	crispr	crispr	ADJ
ajmsi-1760	58	3	-	-	PUNCT
ajmsi-1760	58	4	cas9	cas9	NOUN
ajmsi-1760	58	5	nuclease	nuclease	NOUN
ajmsi-1760	58	6	system	system	NOUN
ajmsi-1760	58	7	effectively	effectively	ADV
ajmsi-1760	58	8	suppresses	suppress	VERB
ajmsi-1760	58	9	bcl11a	bcl11a	ADJ
ajmsi-1760	58	10	expression	expression	NOUN
ajmsi-1760	58	11	in	in	ADP
ajmsi-1760	58	12	erythroid	erythroid	ADJ
ajmsi-1760	58	13	-	-	PUNCT
ajmsi-1760	58	14	lineage	lineage	NOUN
ajmsi-1760	58	15	cells	cell	NOUN
ajmsi-1760	58	16	,	,	PUNCT
ajmsi-1760	58	17	thereby	thereby	ADV
ajmsi-1760	58	18	restoring	restore	VERB
ajmsi-1760	58	19	γ	γ	X
ajmsi-1760	58	20	-	-	PUNCT
ajmsi-1760	58	21	globin	globin	ADJ
ajmsi-1760	58	22	synthesis	synthesis	NOUN
ajmsi-1760	58	23	and	and	CCONJ
ajmsi-1760	58	24	reactivating	reactivate	VERB
ajmsi-1760	58	25	hbf	hbf	PROPN
ajmsi-1760	58	26	production	production	NOUN
ajmsi-1760	58	27	(	(	PUNCT
ajmsi-1760	58	28	canver	canver	NOUN
ajmsi-1760	58	29	,	,	PUNCT
ajmsi-1760	58	30	2015	2015	NUM
ajmsi-1760	58	31	;	;	PUNCT
ajmsi-1760	58	32	wu	wu	PROPN
ajmsi-1760	58	33	,	,	PUNCT
ajmsi-1760	58	34	2019	2019	NUM
ajmsi-1760	58	35	)	)	PUNCT
ajmsi-1760	58	36	.	.	PUNCT
ajmsi-1760	59	1	unlike	unlike	ADP
ajmsi-1760	59	2	previous	previous	ADJ
ajmsi-1760	59	3	genomic	genomic	NOUN
ajmsi-1760	59	4	editing	editing	NOUN
ajmsi-1760	59	5	methods	method	NOUN
ajmsi-1760	59	6	,	,	PUNCT
ajmsi-1760	59	7	crispr	crispr	NOUN
ajmsi-1760	59	8	-	-	PUNCT
ajmsi-1760	59	9	cas9	cas9	NOUN
ajmsi-1760	59	10	has	have	VERB
ajmsi-1760	59	11	the	the	DET
ajmsi-1760	59	12	capacity	capacity	NOUN
ajmsi-1760	59	13	to	to	PART
ajmsi-1760	59	14	target	target	VERB
ajmsi-1760	59	15	multiple	multiple	ADJ
ajmsi-1760	59	16	genes	gene	NOUN
ajmsi-1760	59	17	simultaneously	simultaneously	ADV
ajmsi-1760	59	18	,	,	PUNCT
ajmsi-1760	59	19	enabling	enable	VERB
ajmsi-1760	59	20	the	the	DET
ajmsi-1760	59	21	treatment	treatment	NOUN
ajmsi-1760	59	22	of	of	ADP
ajmsi-1760	59	23	not	not	PART
ajmsi-1760	59	24	only	only	ADV
ajmsi-1760	59	25	diseases	disease	NOUN
ajmsi-1760	59	26	with	with	ADP
ajmsi-1760	59	27	point	point	NOUN
ajmsi-1760	59	28	mutations	mutation	NOUN
ajmsi-1760	59	29	but	but	CCONJ
ajmsi-1760	59	30	also	also	ADV
ajmsi-1760	59	31	those	those	PRON
ajmsi-1760	59	32	with	with	ADP
ajmsi-1760	59	33	polygenic	polygenic	ADJ
ajmsi-1760	59	34	mutations	mutation	NOUN
ajmsi-1760	59	35	.	.	PUNCT
ajmsi-1760	60	1	researchers	researcher	NOUN
ajmsi-1760	60	2	have	have	AUX
ajmsi-1760	60	3	recently	recently	ADV
ajmsi-1760	60	4	realized	realize	VERB
ajmsi-1760	60	5	that	that	SCONJ
ajmsi-1760	60	6	this	this	DET
ajmsi-1760	60	7	system	system	NOUN
ajmsi-1760	60	8	can	can	AUX
ajmsi-1760	60	9	be	be	AUX
ajmsi-1760	60	10	engineered	engineer	VERB
ajmsi-1760	60	11	to	to	PART
ajmsi-1760	60	12	cleave	cleave	VERB
ajmsi-1760	60	13	dna	dna	NOUN
ajmsi-1760	60	14	at	at	ADP
ajmsi-1760	60	15	precisely	precisely	ADV
ajmsi-1760	60	16	chosen	choose	VERB
ajmsi-1760	60	17	loci	locus	NOUN
ajmsi-1760	60	18	,	,	PUNCT
ajmsi-1760	60	19	extending	extend	VERB
ajmsi-1760	60	20	beyond	beyond	ADP
ajmsi-1760	60	21	viral	viral	ADJ
ajmsi-1760	60	22	dna	dna	NOUN
ajmsi-1760	60	23	to	to	ADP
ajmsi-1760	60	24	any	any	DET
ajmsi-1760	60	25	desired	desire	VERB
ajmsi-1760	60	26	dna	dna	NOUN
ajmsi-1760	60	27	sequence	sequence	NOUN
ajmsi-1760	60	28	,	,	PUNCT
ajmsi-1760	60	29	simply	simply	ADV
ajmsi-1760	60	30	by	by	ADP
ajmsi-1760	60	31	modifying	modify	VERB
ajmsi-1760	60	32	the	the	DET
ajmsi-1760	60	33	guiderna	guiderna	NOUN
ajmsi-1760	60	34	to	to	PART
ajmsi-1760	60	35	match	match	VERB
ajmsi-1760	60	36	the	the	DET
ajmsi-1760	60	37	target	target	NOUN
ajmsi-1760	60	38	(	(	PUNCT
ajmsi-1760	60	39	chaudhary	chaudhary	PROPN
ajmsi-1760	60	40	,	,	PUNCT
ajmsi-1760	60	41	2020	2020	NUM
ajmsi-1760	60	42	)	)	PUNCT
ajmsi-1760	60	43	.	.	PUNCT
ajmsi-1760	61	1	in	in	ADP
ajmsi-1760	61	2	this	this	DET
ajmsi-1760	61	3	systematic	systematic	ADJ
ajmsi-1760	61	4	review	review	NOUN
ajmsi-1760	61	5	,	,	PUNCT
ajmsi-1760	61	6	a	a	DET
ajmsi-1760	61	7	comprehensive	comprehensive	ADJ
ajmsi-1760	61	8	analysis	analysis	NOUN
ajmsi-1760	61	9	of	of	ADP
ajmsi-1760	61	10	the	the	DET
ajmsi-1760	61	11	current	current	ADJ
ajmsi-1760	61	12	state	state	NOUN
ajmsi-1760	61	13	of	of	ADP
ajmsi-1760	61	14	research	research	NOUN
ajmsi-1760	61	15	on	on	ADP
ajmsi-1760	61	16	crispr	crispr	NOUN
ajmsi-1760	61	17	-	-	PUNCT
ajmsi-1760	61	18	cas9	cas9	NOUN
ajmsi-1760	61	19	for	for	ADP
ajmsi-1760	61	20	the	the	DET
ajmsi-1760	61	21	treatment	treatment	NOUN
ajmsi-1760	61	22	of	of	ADP
ajmsi-1760	61	23	sickle	sickle	NOUN
ajmsi-1760	61	24	cell	cell	NOUN
ajmsi-1760	61	25	disease	disease	NOUN
ajmsi-1760	61	26	(	(	PUNCT
ajmsi-1760	61	27	scd	scd	NOUN
ajmsi-1760	61	28	)	)	PUNCT
ajmsi-1760	61	29	was	be	AUX
ajmsi-1760	61	30	conducted	conduct	VERB
ajmsi-1760	61	31	.	.	PUNCT
ajmsi-1760	62	1	by	by	ADP
ajmsi-1760	62	2	gathering	gather	VERB
ajmsi-1760	62	3	information	information	NOUN
ajmsi-1760	62	4	from	from	ADP
ajmsi-1760	62	5	multiple	multiple	ADJ
ajmsi-1760	62	6	sources	source	NOUN
ajmsi-1760	62	7	,	,	PUNCT
ajmsi-1760	62	8	evaluation	evaluation	NOUN
ajmsi-1760	62	9	of	of	ADP
ajmsi-1760	62	10	the	the	DET
ajmsi-1760	62	11	progress	progress	NOUN
ajmsi-1760	62	12	made	make	VERB
ajmsi-1760	62	13	with	with	ADP
ajmsi-1760	62	14	this	this	DET
ajmsi-1760	62	15	innovative	innovative	ADJ
ajmsi-1760	62	16	technology	technology	NOUN
ajmsi-1760	62	17	is	be	AUX
ajmsi-1760	62	18	determined	determine	VERB
ajmsi-1760	62	19	,	,	PUNCT
ajmsi-1760	62	20	identified	identify	VERB
ajmsi-1760	62	21	knowledge	knowledge	NOUN
ajmsi-1760	62	22	gaps	gap	NOUN
ajmsi-1760	62	23	for	for	ADP
ajmsi-1760	62	24	further	further	ADJ
ajmsi-1760	62	25	research	research	NOUN
ajmsi-1760	62	26	are	be	AUX
ajmsi-1760	62	27	checked	check	VERB
ajmsi-1760	62	28	,	,	PUNCT
ajmsi-1760	62	29	and	and	CCONJ
ajmsi-1760	62	30	the	the	DET
ajmsi-1760	62	31	technology	technology	NOUN
ajmsi-1760	62	32	’s	’s	PART
ajmsi-1760	62	33	potential	potential	ADJ
ajmsi-1760	62	34	challenges	challenge	NOUN
ajmsi-1760	62	35	and	and	CCONJ
ajmsi-1760	62	36	limitations	limitation	NOUN
ajmsi-1760	62	37	are	be	AUX
ajmsi-1760	62	38	discussed	discuss	VERB
ajmsi-1760	62	39	.	.	PUNCT
ajmsi-1760	63	1	methodology	methodology	NOUN
ajmsi-1760	63	2	search	search	NOUN
ajmsi-1760	63	3	strategy	strategy	NOUN
ajmsi-1760	63	4	and	and	CCONJ
ajmsi-1760	63	5	selection	selection	NOUN
ajmsi-1760	63	6	criteria	criterion	NOUN
ajmsi-1760	63	7	this	this	DET
ajmsi-1760	63	8	systematic	systematic	ADJ
ajmsi-1760	63	9	review	review	NOUN
ajmsi-1760	63	10	aimed	aim	VERB
ajmsi-1760	63	11	to	to	PART
ajmsi-1760	63	12	study	study	VERB
ajmsi-1760	63	13	all	all	DET
ajmsi-1760	63	14	available	available	ADJ
ajmsi-1760	63	15	literature	literature	NOUN
ajmsi-1760	63	16	on	on	ADP
ajmsi-1760	63	17	crispr	crispr	ADJ
ajmsi-1760	63	18	-	-	PUNCT
ajmsi-1760	63	19	cas9	cas9	NOUN
ajmsi-1760	63	20	genomic	genomic	NOUN
ajmsi-1760	63	21	editing	editing	NOUN
ajmsi-1760	63	22	and	and	CCONJ
ajmsi-1760	63	23	its	its	PRON
ajmsi-1760	63	24	potential	potential	NOUN
ajmsi-1760	63	25	in	in	ADP
ajmsi-1760	63	26	the	the	DET
ajmsi-1760	63	27	management	management	NOUN
ajmsi-1760	63	28	of	of	ADP
ajmsi-1760	63	29	scd	scd	PROPN
ajmsi-1760	63	30	.	.	PUNCT
ajmsi-1760	64	1	it	it	PRON
ajmsi-1760	64	2	also	also	ADV
ajmsi-1760	64	3	sought	seek	VERB
ajmsi-1760	64	4	to	to	PART
ajmsi-1760	64	5	shed	shed	VERB
ajmsi-1760	64	6	more	more	ADJ
ajmsi-1760	64	7	light	light	NOUN
ajmsi-1760	64	8	on	on	ADP
ajmsi-1760	64	9	pa	pa	PROPN
ajmsi-1760	64	10	ge	ge	PROPN
ajmsi-1760	64	11	46	46	NUM
ajmsi-1760	64	12	https://journals.e-palli.com/home/index.php/ajmsi	https://journals.e-palli.com/home/index.php/ajmsi	PROPN
ajmsi-1760	64	13	am	be	AUX
ajmsi-1760	64	14	.	.	PUNCT
ajmsi-1760	65	1	j.	j.	PROPN
ajmsi-1760	65	2	med	med	PROPN
ajmsi-1760	65	3	.	.	PUNCT
ajmsi-1760	66	1	sci	sci	PROPN
ajmsi-1760	66	2	.	.	PUNCT
ajmsi-1760	66	3	innov	innov	PROPN
ajmsi-1760	66	4	.	.	PUNCT
ajmsi-1760	67	1	2(2	2(2	NUM
ajmsi-1760	67	2	)	)	PUNCT
ajmsi-1760	67	3	44	44	NUM
ajmsi-1760	67	4	-	-	SYM
ajmsi-1760	67	5	56	56	NUM
ajmsi-1760	67	6	,	,	PUNCT
ajmsi-1760	67	7	2023	2023	NUM
ajmsi-1760	67	8	the	the	DET
ajmsi-1760	67	9	subject	subject	ADJ
ajmsi-1760	67	10	matter	matter	NOUN
ajmsi-1760	67	11	(	(	PUNCT
ajmsi-1760	67	12	considering	consider	VERB
ajmsi-1760	67	13	the	the	DET
ajmsi-1760	67	14	fact	fact	NOUN
ajmsi-1760	67	15	this	this	DET
ajmsi-1760	67	16	technology	technology	NOUN
ajmsi-1760	67	17	is	be	AUX
ajmsi-1760	67	18	novel	novel	ADJ
ajmsi-1760	67	19	)	)	PUNCT
ajmsi-1760	67	20	and	and	CCONJ
ajmsi-1760	67	21	its	its	PRON
ajmsi-1760	67	22	stage	stage	NOUN
ajmsi-1760	67	23	of	of	ADP
ajmsi-1760	67	24	development	development	NOUN
ajmsi-1760	67	25	is	be	AUX
ajmsi-1760	67	26	still	still	ADV
ajmsi-1760	67	27	in	in	ADP
ajmsi-1760	67	28	the	the	DET
ajmsi-1760	67	29	clinical	clinical	ADJ
ajmsi-1760	67	30	trials	trial	NOUN
ajmsi-1760	67	31	.	.	PUNCT
ajmsi-1760	68	1	a	a	DET
ajmsi-1760	68	2	similar	similar	ADJ
ajmsi-1760	68	3	method	method	NOUN
ajmsi-1760	68	4	of	of	ADP
ajmsi-1760	68	5	literature	literature	NOUN
ajmsi-1760	68	6	search	search	NOUN
ajmsi-1760	68	7	as	as	SCONJ
ajmsi-1760	68	8	described	describe	VERB
ajmsi-1760	68	9	by	by	ADP
ajmsi-1760	68	10	suwito	suwito	PROPN
ajmsi-1760	68	11	,	,	PUNCT
ajmsi-1760	68	12	et	et	PROPN
ajmsi-1760	68	13	al	al	PROPN
ajmsi-1760	68	14	,	,	PUNCT
ajmsi-1760	68	15	2023	2023	NUM
ajmsi-1760	68	16	was	be	AUX
ajmsi-1760	68	17	used	use	VERB
ajmsi-1760	68	18	(	(	PUNCT
ajmsi-1760	68	19	suwito	suwito	ADJ
ajmsi-1760	68	20	,	,	PUNCT
ajmsi-1760	68	21	2023	2023	NUM
ajmsi-1760	68	22	)	)	PUNCT
ajmsi-1760	68	23	.	.	PUNCT
ajmsi-1760	69	1	the	the	DET
ajmsi-1760	69	2	literature	literature	NOUN
ajmsi-1760	69	3	search	search	NOUN
ajmsi-1760	69	4	was	be	AUX
ajmsi-1760	69	5	done	do	VERB
ajmsi-1760	69	6	from	from	ADP
ajmsi-1760	69	7	the	the	DET
ajmsi-1760	69	8	following	follow	VERB
ajmsi-1760	69	9	databases	database	NOUN
ajmsi-1760	69	10	over	over	ADP
ajmsi-1760	69	11	a	a	DET
ajmsi-1760	69	12	period	period	NOUN
ajmsi-1760	69	13	of	of	ADP
ajmsi-1760	69	14	2	2	NUM
ajmsi-1760	69	15	weeks	week	NOUN
ajmsi-1760	69	16	:	:	PUNCT
ajmsi-1760	69	17	pubmed	pubmed	PROPN
ajmsi-1760	69	18	(	(	PUNCT
ajmsi-1760	69	19	mostly	mostly	ADV
ajmsi-1760	69	20	used	use	VERB
ajmsi-1760	69	21	)	)	PUNCT
ajmsi-1760	69	22	,	,	PUNCT
ajmsi-1760	69	23	google	google	NOUN
ajmsi-1760	69	24	scholar	scholar	NOUN
ajmsi-1760	69	25	,	,	PUNCT
ajmsi-1760	69	26	and	and	CCONJ
ajmsi-1760	69	27	african	african	ADJ
ajmsi-1760	69	28	journals	journal	NOUN
ajmsi-1760	69	29	online	online	ADV
ajmsi-1760	69	30	(	(	PUNCT
ajmsi-1760	69	31	ajol	ajol	NOUN
ajmsi-1760	69	32	)	)	PUNCT
ajmsi-1760	69	33	using	use	VERB
ajmsi-1760	69	34	the	the	DET
ajmsi-1760	69	35	following	following	ADJ
ajmsi-1760	69	36	terms	term	NOUN
ajmsi-1760	69	37	:	:	PUNCT
ajmsi-1760	69	38	crispr	crispr	NOUN
ajmsi-1760	69	39	-	-	PUNCT
ajmsi-1760	69	40	cas9	cas9	NOUN
ajmsi-1760	69	41	,	,	PUNCT
ajmsi-1760	69	42	genomic	genomic	NOUN
ajmsi-1760	69	43	editing	editing	NOUN
ajmsi-1760	69	44	,	,	PUNCT
ajmsi-1760	69	45	gene	gene	NOUN
ajmsi-1760	69	46	editing	editing	NOUN
ajmsi-1760	69	47	,	,	PUNCT
ajmsi-1760	69	48	sickle	sickle	NOUN
ajmsi-1760	69	49	cell	cell	NOUN
ajmsi-1760	69	50	disease	disease	NOUN
ajmsi-1760	69	51	,	,	PUNCT
ajmsi-1760	69	52	hemoglobinopathies	hemoglobinopathy	NOUN
ajmsi-1760	69	53	,	,	PUNCT
ajmsi-1760	69	54	sickle	sickle	NOUN
ajmsi-1760	69	55	cell	cell	NOUN
ajmsi-1760	69	56	anemia	anemia	NOUN
ajmsi-1760	69	57	,	,	PUNCT
ajmsi-1760	69	58	genetic	genetic	ADJ
ajmsi-1760	69	59	therapy	therapy	NOUN
ajmsi-1760	69	60	,	,	PUNCT
ajmsi-1760	69	61	systematic	systematic	ADJ
ajmsi-1760	69	62	review	review	NOUN
ajmsi-1760	69	63	,	,	PUNCT
ajmsi-1760	69	64	new	new	ADJ
ajmsi-1760	69	65	therapy	therapy	NOUN
ajmsi-1760	69	66	/	/	SYM
ajmsi-1760	69	67	novel	novel	NOUN
ajmsi-1760	69	68	intervention	intervention	NOUN
ajmsi-1760	69	69	for	for	ADP
ajmsi-1760	69	70	sickle	sickle	NOUN
ajmsi-1760	69	71	cell	cell	NOUN
ajmsi-1760	69	72	disease	disease	NOUN
ajmsi-1760	69	73	cure	cure	NOUN
ajmsi-1760	69	74	/	/	SYM
ajmsi-1760	69	75	treatment	treatment	NOUN
ajmsi-1760	69	76	.	.	PUNCT
ajmsi-1760	70	1	data	datum	NOUN
ajmsi-1760	70	2	sources	source	NOUN
ajmsi-1760	70	3	and	and	CCONJ
ajmsi-1760	70	4	search	search	NOUN
ajmsi-1760	70	5	engines	engine	NOUN
ajmsi-1760	70	6	a	a	DET
ajmsi-1760	70	7	literature	literature	NOUN
ajmsi-1760	70	8	search	search	NOUN
ajmsi-1760	70	9	was	be	AUX
ajmsi-1760	70	10	done	do	VERB
ajmsi-1760	70	11	from	from	ADP
ajmsi-1760	70	12	the	the	DET
ajmsi-1760	70	13	following	following	ADJ
ajmsi-1760	70	14	databases	database	NOUN
ajmsi-1760	70	15	:	:	PUNCT
ajmsi-1760	70	16	pubmed	pubmed	PROPN
ajmsi-1760	70	17	(	(	PUNCT
ajmsi-1760	70	18	mostly	mostly	ADV
ajmsi-1760	70	19	used	use	VERB
ajmsi-1760	70	20	)	)	PUNCT
ajmsi-1760	70	21	,	,	PUNCT
ajmsi-1760	70	22	google	google	NOUN
ajmsi-1760	70	23	scholar	scholar	NOUN
ajmsi-1760	70	24	,	,	PUNCT
ajmsi-1760	70	25	and	and	CCONJ
ajmsi-1760	70	26	african	african	ADJ
ajmsi-1760	70	27	journals	journal	NOUN
ajmsi-1760	70	28	online	online	ADV
ajmsi-1760	70	29	(	(	PUNCT
ajmsi-1760	70	30	ajol	ajol	NOUN
ajmsi-1760	70	31	)	)	PUNCT
ajmsi-1760	70	32	.	.	PUNCT
ajmsi-1760	71	1	while	while	SCONJ
ajmsi-1760	71	2	the	the	DET
ajmsi-1760	71	3	clinical	clinical	ADJ
ajmsi-1760	71	4	trials	trial	NOUN
ajmsi-1760	71	5	search	search	NOUN
ajmsi-1760	71	6	was	be	AUX
ajmsi-1760	71	7	done	do	VERB
ajmsi-1760	71	8	on	on	ADP
ajmsi-1760	71	9	clinicaltrials.gov	clinicaltrials.gov	PROPN
ajmsi-1760	71	10	.	.	PUNCT
ajmsi-1760	71	11	inclusion	inclusion	NOUN
ajmsi-1760	71	12	and	and	CCONJ
ajmsi-1760	71	13	exclusion	exclusion	NOUN
ajmsi-1760	71	14	criteria	criterion	NOUN
ajmsi-1760	71	15	included	include	VERB
ajmsi-1760	71	16	in	in	ADP
ajmsi-1760	71	17	this	this	DET
ajmsi-1760	71	18	study	study	NOUN
ajmsi-1760	71	19	were	be	AUX
ajmsi-1760	71	20	studies	study	NOUN
ajmsi-1760	71	21	that	that	PRON
ajmsi-1760	71	22	investigated	investigate	VERB
ajmsi-1760	71	23	the	the	DET
ajmsi-1760	71	24	use	use	NOUN
ajmsi-1760	71	25	of	of	ADP
ajmsi-1760	71	26	crispr	crispr	ADJ
ajmsi-1760	71	27	-	-	PUNCT
ajmsi-1760	71	28	cas9	cas9	NOUN
ajmsi-1760	71	29	genomic	genomic	NOUN
ajmsi-1760	71	30	editing	editing	NOUN
ajmsi-1760	71	31	as	as	ADP
ajmsi-1760	71	32	a	a	DET
ajmsi-1760	71	33	treatment	treatment	NOUN
ajmsi-1760	71	34	for	for	ADP
ajmsi-1760	71	35	sickle	sickle	NOUN
ajmsi-1760	71	36	cell	cell	NOUN
ajmsi-1760	71	37	disease	disease	NOUN
ajmsi-1760	71	38	,	,	PUNCT
ajmsi-1760	71	39	studies	study	NOUN
ajmsi-1760	71	40	that	that	PRON
ajmsi-1760	71	41	included	include	VERB
ajmsi-1760	71	42	human	human	ADJ
ajmsi-1760	71	43	participants	participant	NOUN
ajmsi-1760	71	44	or	or	CCONJ
ajmsi-1760	71	45	human	human	ADJ
ajmsi-1760	71	46	cells	cell	NOUN
ajmsi-1760	71	47	/	/	SYM
ajmsi-1760	71	48	tissues	tissue	NOUN
ajmsi-1760	71	49	,	,	PUNCT
ajmsi-1760	71	50	studies	study	NOUN
ajmsi-1760	71	51	that	that	PRON
ajmsi-1760	71	52	provided	provide	VERB
ajmsi-1760	71	53	data	datum	NOUN
ajmsi-1760	71	54	on	on	ADP
ajmsi-1760	71	55	the	the	DET
ajmsi-1760	71	56	efficacy	efficacy	NOUN
ajmsi-1760	71	57	and/or	and/or	CCONJ
ajmsi-1760	71	58	safety	safety	NOUN
ajmsi-1760	71	59	of	of	ADP
ajmsi-1760	71	60	crispr	crispr	ADJ
ajmsi-1760	71	61	-	-	PUNCT
ajmsi-1760	71	62	cas9	cas9	NOUN
ajmsi-1760	71	63	genomic	genomic	NOUN
ajmsi-1760	71	64	editing	edit	VERB
ajmsi-1760	71	65	for	for	ADP
ajmsi-1760	71	66	sickle	sickle	NOUN
ajmsi-1760	71	67	cell	cell	NOUN
ajmsi-1760	71	68	disease	disease	NOUN
ajmsi-1760	71	69	,	,	PUNCT
ajmsi-1760	71	70	and	and	CCONJ
ajmsi-1760	71	71	studies	study	NOUN
ajmsi-1760	71	72	that	that	PRON
ajmsi-1760	71	73	were	be	AUX
ajmsi-1760	71	74	published	publish	VERB
ajmsi-1760	71	75	in	in	ADP
ajmsi-1760	71	76	english	english	ADJ
ajmsi-1760	71	77	language	language	NOUN
ajmsi-1760	71	78	within	within	ADP
ajmsi-1760	71	79	the	the	DET
ajmsi-1760	71	80	past	past	ADJ
ajmsi-1760	71	81	10	10	NUM
ajmsi-1760	71	82	years	year	NOUN
ajmsi-1760	71	83	on	on	ADP
ajmsi-1760	71	84	gene	gene	NOUN
ajmsi-1760	71	85	therapy	therapy	NOUN
ajmsi-1760	71	86	use	use	NOUN
ajmsi-1760	71	87	in	in	ADP
ajmsi-1760	71	88	scd	scd	PROPN
ajmsi-1760	71	89	,	,	PUNCT
ajmsi-1760	71	90	specifically	specifically	ADV
ajmsi-1760	71	91	crispr	crispr	ADJ
ajmsi-1760	71	92	-	-	PUNCT
ajmsi-1760	71	93	cas9	cas9	NOUN
ajmsi-1760	71	94	.	.	PUNCT
ajmsi-1760	72	1	excluded	exclude	VERB
ajmsi-1760	72	2	articles	article	NOUN
ajmsi-1760	72	3	were	be	AUX
ajmsi-1760	72	4	studies	study	NOUN
ajmsi-1760	72	5	not	not	PART
ajmsi-1760	72	6	related	relate	VERB
ajmsi-1760	72	7	to	to	ADP
ajmsi-1760	72	8	crispr	crispr	ADJ
ajmsi-1760	72	9	-	-	PUNCT
ajmsi-1760	72	10	cas9	cas9	NOUN
ajmsi-1760	72	11	genomic	genomic	NOUN
ajmsi-1760	72	12	editing	editing	NOUN
ajmsi-1760	72	13	or	or	CCONJ
ajmsi-1760	72	14	sickle	sickle	NOUN
ajmsi-1760	72	15	cell	cell	NOUN
ajmsi-1760	72	16	disease	disease	NOUN
ajmsi-1760	72	17	,	,	PUNCT
ajmsi-1760	72	18	studies	study	NOUN
ajmsi-1760	72	19	that	that	PRON
ajmsi-1760	72	20	used	use	VERB
ajmsi-1760	72	21	animal	animal	NOUN
ajmsi-1760	72	22	or	or	CCONJ
ajmsi-1760	72	23	plant	plant	NOUN
ajmsi-1760	72	24	models	model	NOUN
ajmsi-1760	72	25	only	only	ADV
ajmsi-1760	72	26	,	,	PUNCT
ajmsi-1760	72	27	studies	study	NOUN
ajmsi-1760	72	28	not	not	PART
ajmsi-1760	72	29	published	publish	VERB
ajmsi-1760	72	30	in	in	ADP
ajmsi-1760	72	31	english	english	PROPN
ajmsi-1760	72	32	,	,	PUNCT
ajmsi-1760	72	33	studies	study	NOUN
ajmsi-1760	72	34	that	that	PRON
ajmsi-1760	72	35	did	do	AUX
ajmsi-1760	72	36	not	not	PART
ajmsi-1760	72	37	provide	provide	VERB
ajmsi-1760	72	38	data	datum	NOUN
ajmsi-1760	72	39	on	on	ADP
ajmsi-1760	72	40	the	the	DET
ajmsi-1760	72	41	efficacy	efficacy	NOUN
ajmsi-1760	72	42	and/or	and/or	CCONJ
ajmsi-1760	72	43	safety	safety	NOUN
ajmsi-1760	72	44	of	of	ADP
ajmsi-1760	72	45	crispr	crispr	ADJ
ajmsi-1760	72	46	-	-	PUNCT
ajmsi-1760	72	47	cas9	cas9	NOUN
ajmsi-1760	72	48	genomic	genomic	NOUN
ajmsi-1760	72	49	editing	edit	VERB
ajmsi-1760	72	50	for	for	ADP
ajmsi-1760	72	51	sickle	sickle	NOUN
ajmsi-1760	72	52	cell	cell	NOUN
ajmsi-1760	72	53	disease	disease	NOUN
ajmsi-1760	72	54	,	,	PUNCT
ajmsi-1760	72	55	and	and	CCONJ
ajmsi-1760	72	56	studies	study	NOUN
ajmsi-1760	72	57	that	that	PRON
ajmsi-1760	72	58	had	have	VERB
ajmsi-1760	72	59	poor	poor	ADJ
ajmsi-1760	72	60	methodological	methodological	ADJ
ajmsi-1760	72	61	quality	quality	NOUN
ajmsi-1760	72	62	or	or	CCONJ
ajmsi-1760	72	63	a	a	DET
ajmsi-1760	72	64	high	high	ADJ
ajmsi-1760	72	65	risk	risk	NOUN
ajmsi-1760	72	66	of	of	ADP
ajmsi-1760	72	67	bias	bias	NOUN
ajmsi-1760	72	68	.	.	PUNCT
ajmsi-1760	73	1	quality	quality	NOUN
ajmsi-1760	73	2	assessment	assessment	NOUN
ajmsi-1760	73	3	of	of	ADP
ajmsi-1760	73	4	included	include	VERB
ajmsi-1760	73	5	studies	study	NOUN
ajmsi-1760	73	6	the	the	DET
ajmsi-1760	73	7	articles	article	NOUN
ajmsi-1760	73	8	from	from	ADP
ajmsi-1760	73	9	the	the	DET
ajmsi-1760	73	10	database	database	NOUN
ajmsi-1760	73	11	search	search	NOUN
ajmsi-1760	73	12	were	be	AUX
ajmsi-1760	73	13	reviewed	review	VERB
ajmsi-1760	73	14	to	to	PART
ajmsi-1760	73	15	tailor	tailor	VERB
ajmsi-1760	73	16	them	they	PRON
ajmsi-1760	73	17	to	to	ADP
ajmsi-1760	73	18	the	the	DET
ajmsi-1760	73	19	inclusion	inclusion	NOUN
ajmsi-1760	73	20	criteria	criterion	NOUN
ajmsi-1760	73	21	.	.	PUNCT
ajmsi-1760	74	1	the	the	DET
ajmsi-1760	74	2	abstracts	abstract	NOUN
ajmsi-1760	74	3	of	of	ADP
ajmsi-1760	74	4	the	the	DET
ajmsi-1760	74	5	articles	article	NOUN
ajmsi-1760	74	6	that	that	PRON
ajmsi-1760	74	7	met	meet	VERB
ajmsi-1760	74	8	the	the	DET
ajmsi-1760	74	9	inclusion	inclusion	NOUN
ajmsi-1760	74	10	criteria	criterion	NOUN
ajmsi-1760	74	11	were	be	AUX
ajmsi-1760	74	12	reviewed	review	VERB
ajmsi-1760	74	13	for	for	ADP
ajmsi-1760	74	14	relevant	relevant	ADJ
ajmsi-1760	74	15	keywords	keyword	NOUN
ajmsi-1760	74	16	.	.	PUNCT
ajmsi-1760	75	1	the	the	DET
ajmsi-1760	75	2	abstracts	abstract	NOUN
ajmsi-1760	75	3	and	and	CCONJ
ajmsi-1760	75	4	the	the	DET
ajmsi-1760	75	5	free	free	ADJ
ajmsi-1760	75	6	complete	complete	ADJ
ajmsi-1760	75	7	articles	article	NOUN
ajmsi-1760	75	8	i.e.	i.e.	X
ajmsi-1760	75	9	manuscripts	manuscript	NOUN
ajmsi-1760	75	10	for	for	ADP
ajmsi-1760	75	11	the	the	DET
ajmsi-1760	75	12	selected	select	VERB
ajmsi-1760	75	13	articles	article	NOUN
ajmsi-1760	75	14	were	be	AUX
ajmsi-1760	75	15	then	then	ADV
ajmsi-1760	75	16	read	read	VERB
ajmsi-1760	75	17	,	,	PUNCT
ajmsi-1760	75	18	reviewed	review	VERB
ajmsi-1760	75	19	,	,	PUNCT
ajmsi-1760	75	20	and	and	CCONJ
ajmsi-1760	75	21	the	the	DET
ajmsi-1760	75	22	information	information	NOUN
ajmsi-1760	75	23	on	on	ADP
ajmsi-1760	75	24	each	each	PRON
ajmsi-1760	75	25	of	of	ADP
ajmsi-1760	75	26	the	the	DET
ajmsi-1760	75	27	key	key	ADJ
ajmsi-1760	75	28	areas	area	NOUN
ajmsi-1760	75	29	were	be	AUX
ajmsi-1760	75	30	summarized	summarize	VERB
ajmsi-1760	75	31	.	.	PUNCT
ajmsi-1760	76	1	this	this	DET
ajmsi-1760	76	2	systematic	systematic	ADJ
ajmsi-1760	76	3	review	review	NOUN
ajmsi-1760	76	4	was	be	AUX
ajmsi-1760	76	5	carried	carry	VERB
ajmsi-1760	76	6	out	out	ADP
ajmsi-1760	76	7	independently	independently	ADV
ajmsi-1760	76	8	by	by	ADP
ajmsi-1760	76	9	four	four	NUM
ajmsi-1760	76	10	persons	person	NOUN
ajmsi-1760	76	11	,	,	PUNCT
ajmsi-1760	76	12	to	to	PART
ajmsi-1760	76	13	minimize	minimize	VERB
ajmsi-1760	76	14	errors	error	NOUN
ajmsi-1760	76	15	.	.	PUNCT
ajmsi-1760	77	1	the	the	DET
ajmsi-1760	77	2	summarized	summarize	VERB
ajmsi-1760	77	3	data	datum	NOUN
ajmsi-1760	77	4	were	be	AUX
ajmsi-1760	77	5	later	later	ADV
ajmsi-1760	77	6	compiled	compile	VERB
ajmsi-1760	77	7	,	,	PUNCT
ajmsi-1760	77	8	reviewed	review	VERB
ajmsi-1760	77	9	,	,	PUNCT
ajmsi-1760	77	10	and	and	CCONJ
ajmsi-1760	77	11	discussed	discuss	VERB
ajmsi-1760	77	12	.	.	PUNCT
ajmsi-1760	78	1	data	datum	NOUN
ajmsi-1760	78	2	extraction	extraction	NOUN
ajmsi-1760	78	3	,	,	PUNCT
ajmsi-1760	78	4	synthesis	synthesis	NOUN
ajmsi-1760	78	5	,	,	PUNCT
ajmsi-1760	78	6	and	and	CCONJ
ajmsi-1760	78	7	results	result	VERB
ajmsi-1760	78	8	the	the	DET
ajmsi-1760	78	9	following	follow	VERB
ajmsi-1760	78	10	keywords	keyword	NOUN
ajmsi-1760	78	11	were	be	AUX
ajmsi-1760	78	12	used	use	VERB
ajmsi-1760	78	13	to	to	PART
ajmsi-1760	78	14	extract	extract	VERB
ajmsi-1760	78	15	articles	article	NOUN
ajmsi-1760	78	16	from	from	ADP
ajmsi-1760	78	17	database	database	NOUN
ajmsi-1760	78	18	searches	search	NOUN
ajmsi-1760	78	19	:	:	PUNCT
ajmsi-1760	78	20	•	•	NUM
ajmsi-1760	78	21	“	"	PUNCT
ajmsi-1760	78	22	crispr	crispr	ADJ
ajmsi-1760	78	23	-	-	PUNCT
ajmsi-1760	78	24	cas9	cas9	NOUN
ajmsi-1760	78	25	”	"	PUNCT
ajmsi-1760	78	26	•	•	NUM
ajmsi-1760	78	27	“	"	PUNCT
ajmsi-1760	78	28	genomic	genomic	NOUN
ajmsi-1760	78	29	editing	editing	NOUN
ajmsi-1760	78	30	”	"	PUNCT
ajmsi-1760	78	31	•	•	NUM
ajmsi-1760	78	32	“	"	PUNCT
ajmsi-1760	78	33	sickle	sickle	NOUN
ajmsi-1760	78	34	cell	cell	NOUN
ajmsi-1760	78	35	disease	disease	NOUN
ajmsi-1760	78	36	,	,	PUNCT
ajmsi-1760	78	37	hemoglobinopathies	hemoglobinopathy	NOUN
ajmsi-1760	78	38	,	,	PUNCT
ajmsi-1760	78	39	and	and	CCONJ
ajmsi-1760	78	40	sickle	sickle	NOUN
ajmsi-1760	78	41	cell	cell	NOUN
ajmsi-1760	78	42	anemia	anemia	NOUN
ajmsi-1760	78	43	”	"	PUNCT
ajmsi-1760	78	44	•	•	NUM
ajmsi-1760	78	45	“	"	PUNCT
ajmsi-1760	78	46	genetic	genetic	ADJ
ajmsi-1760	78	47	therapy	therapy	NOUN
ajmsi-1760	78	48	and	and	CCONJ
ajmsi-1760	78	49	gene	gene	NOUN
ajmsi-1760	78	50	editing	editing	NOUN
ajmsi-1760	78	51	”	"	PUNCT
ajmsi-1760	78	52	•	•	NUM
ajmsi-1760	78	53	“	"	PUNCT
ajmsi-1760	78	54	systematic	systematic	ADJ
ajmsi-1760	78	55	literature	literature	NOUN
ajmsi-1760	78	56	review	review	NOUN
ajmsi-1760	78	57	or	or	CCONJ
ajmsi-1760	78	58	systematic	systematic	ADJ
ajmsi-1760	78	59	review	review	NOUN
ajmsi-1760	78	60	”	"	PUNCT
ajmsi-1760	78	61	•	•	ADJ
ajmsi-1760	78	62	“	"	PUNCT
ajmsi-1760	78	63	new	new	ADJ
ajmsi-1760	78	64	therapy	therapy	NOUN
ajmsi-1760	78	65	/	/	SYM
ajmsi-1760	78	66	novel	novel	NOUN
ajmsi-1760	78	67	intervention	intervention	NOUN
ajmsi-1760	78	68	for	for	ADP
ajmsi-1760	78	69	sickle	sickle	NOUN
ajmsi-1760	78	70	cell	cell	NOUN
ajmsi-1760	78	71	”	"	PUNCT
ajmsi-1760	78	72	.	.	PUNCT
ajmsi-1760	79	1	study	study	NOUN
ajmsi-1760	79	2	selection	selection	NOUN
ajmsi-1760	79	3	and	and	CCONJ
ajmsi-1760	79	4	characteristics	characteristic	NOUN
ajmsi-1760	79	5	the	the	DET
ajmsi-1760	79	6	search	search	NOUN
ajmsi-1760	79	7	for	for	ADP
ajmsi-1760	79	8	articles	article	NOUN
ajmsi-1760	79	9	and	and	CCONJ
ajmsi-1760	79	10	abstracts	abstract	NOUN
ajmsi-1760	79	11	was	be	AUX
ajmsi-1760	79	12	done	do	VERB
ajmsi-1760	79	13	using	use	VERB
ajmsi-1760	79	14	figure	figure	NOUN
ajmsi-1760	79	15	1	1	NUM
ajmsi-1760	79	16	:	:	PUNCT
ajmsi-1760	79	17	steps	step	NOUN
ajmsi-1760	79	18	of	of	ADP
ajmsi-1760	79	19	article	article	NOUN
ajmsi-1760	79	20	selection	selection	NOUN
ajmsi-1760	79	21	keywords	keyword	NOUN
ajmsi-1760	79	22	on	on	ADP
ajmsi-1760	79	23	the	the	DET
ajmsi-1760	79	24	three	three	NUM
ajmsi-1760	79	25	major	major	ADJ
ajmsi-1760	79	26	search	search	NOUN
ajmsi-1760	79	27	engines	engine	NOUN
ajmsi-1760	79	28	(	(	PUNCT
ajmsi-1760	79	29	pubmed	pubmed	PROPN
ajmsi-1760	79	30	,	,	PUNCT
ajmsi-1760	79	31	google	google	NOUN
ajmsi-1760	79	32	scholar	scholar	NOUN
ajmsi-1760	79	33	,	,	PUNCT
ajmsi-1760	79	34	and	and	CCONJ
ajmsi-1760	79	35	ajol	ajol	NOUN
ajmsi-1760	79	36	)	)	PUNCT
ajmsi-1760	79	37	.	.	PUNCT
ajmsi-1760	80	1	however	however	ADV
ajmsi-1760	80	2	,	,	PUNCT
ajmsi-1760	80	3	the	the	DET
ajmsi-1760	80	4	mostly	mostly	ADV
ajmsi-1760	80	5	used	use	VERB
ajmsi-1760	80	6	search	search	NOUN
ajmsi-1760	80	7	engine	engine	NOUN
ajmsi-1760	80	8	was	be	AUX
ajmsi-1760	80	9	pubmed	pubme	VERB
ajmsi-1760	80	10	due	due	ADP
ajmsi-1760	80	11	to	to	ADP
ajmsi-1760	80	12	its	its	PRON
ajmsi-1760	80	13	advanced	advanced	ADJ
ajmsi-1760	80	14	features	feature	NOUN
ajmsi-1760	80	15	and	and	CCONJ
ajmsi-1760	80	16	its	its	PRON
ajmsi-1760	80	17	large	large	ADJ
ajmsi-1760	80	18	repository	repository	NOUN
ajmsi-1760	80	19	of	of	ADP
ajmsi-1760	80	20	articles	article	NOUN
ajmsi-1760	80	21	.	.	PUNCT
ajmsi-1760	81	1	study	study	NOUN
ajmsi-1760	81	2	selection	selection	NOUN
ajmsi-1760	81	3	was	be	AUX
ajmsi-1760	81	4	based	base	VERB
ajmsi-1760	81	5	on	on	ADP
ajmsi-1760	81	6	articles	article	NOUN
ajmsi-1760	81	7	,	,	PUNCT
ajmsi-1760	81	8	abstracts	abstract	NOUN
ajmsi-1760	81	9	,	,	PUNCT
ajmsi-1760	81	10	or	or	CCONJ
ajmsi-1760	81	11	literature	literature	NOUN
ajmsi-1760	81	12	reviews	review	NOUN
ajmsi-1760	81	13	which	which	PRON
ajmsi-1760	81	14	meet	meet	VERB
ajmsi-1760	81	15	the	the	DET
ajmsi-1760	81	16	inclusion	inclusion	NOUN
ajmsi-1760	81	17	criteria	criterion	NOUN
ajmsi-1760	81	18	.	.	PUNCT
ajmsi-1760	82	1	articles	article	NOUN
ajmsi-1760	82	2	that	that	PRON
ajmsi-1760	82	3	were	be	AUX
ajmsi-1760	82	4	found	find	VERB
ajmsi-1760	82	5	under	under	ADP
ajmsi-1760	82	6	exclusion	exclusion	NOUN
ajmsi-1760	82	7	criteria	criterion	NOUN
ajmsi-1760	82	8	were	be	AUX
ajmsi-1760	82	9	discarded	discard	VERB
ajmsi-1760	82	10	.	.	PUNCT
ajmsi-1760	83	1	the	the	DET
ajmsi-1760	83	2	diagram	diagram	NOUN
ajmsi-1760	83	3	below	below	ADV
ajmsi-1760	83	4	illustrates	illustrate	VERB
ajmsi-1760	83	5	how	how	SCONJ
ajmsi-1760	83	6	articles	article	NOUN
ajmsi-1760	83	7	were	be	AUX
ajmsi-1760	83	8	selected	select	VERB
ajmsi-1760	83	9	.	.	PUNCT
ajmsi-1760	84	1	results	result	VERB
ajmsi-1760	84	2	the	the	DET
ajmsi-1760	84	3	findings	finding	NOUN
ajmsi-1760	84	4	in	in	ADP
ajmsi-1760	84	5	this	this	DET
ajmsi-1760	84	6	study	study	NOUN
ajmsi-1760	84	7	are	be	AUX
ajmsi-1760	84	8	outlined	outline	VERB
ajmsi-1760	84	9	in	in	ADP
ajmsi-1760	84	10	tables	table	NOUN
ajmsi-1760	84	11	1	1	NUM
ajmsi-1760	84	12	and	and	CCONJ
ajmsi-1760	84	13	2	2	NUM
ajmsi-1760	84	14	.	.	NOUN
ajmsi-1760	84	15	table	table	NOUN
ajmsi-1760	84	16	1	1	NUM
ajmsi-1760	84	17	:	:	PUNCT
ajmsi-1760	84	18	summary	summary	NOUN
ajmsi-1760	84	19	of	of	ADP
ajmsi-1760	84	20	articles	article	NOUN
ajmsi-1760	84	21	in	in	ADP
ajmsi-1760	84	22	the	the	DET
ajmsi-1760	84	23	literature	literature	NOUN
ajmsi-1760	84	24	search	search	NOUN
ajmsi-1760	84	25	s	s	PROPN
ajmsi-1760	84	26	/	/	SYM
ajmsi-1760	84	27	n	n	CCONJ
ajmsi-1760	84	28	paper	paper	NOUN
ajmsi-1760	84	29	title	title	NOUN
ajmsi-1760	84	30	abstract	abstract	ADJ
ajmsi-1760	84	31	summary	summary	NOUN
ajmsi-1760	84	32	study	study	NOUN
ajmsi-1760	84	33	type	type	NOUN
ajmsi-1760	84	34	outcome	outcome	NOUN
ajmsi-1760	84	35	measured/	measured/	NUM
ajmsi-1760	84	36	summary	summary	NOUN
ajmsi-1760	84	37	of	of	ADP
ajmsi-1760	84	38	conclusion	conclusion	NOUN
ajmsi-1760	84	39	1	1	NUM
ajmsi-1760	84	40	crispr	crispr	ADJ
ajmsi-1760	84	41	-	-	PUNCT
ajmsi-1760	84	42	cas9	cas9	NOUN
ajmsi-1760	84	43	gene	gene	NOUN
ajmsi-1760	84	44	editing	edit	VERB
ajmsi-1760	84	45	for	for	ADP
ajmsi-1760	84	46	sickle	sickle	NOUN
ajmsi-1760	84	47	cell	cell	NOUN
ajmsi-1760	84	48	disease	disease	NOUN
ajmsi-1760	84	49	and	and	CCONJ
ajmsi-1760	84	50	β	β	NOUN
ajmsi-1760	84	51	-	-	NOUN
ajmsi-1760	84	52	thalassemia	thalassemia	NOUN
ajmsi-1760	84	53	(	(	PUNCT
ajmsi-1760	84	54	frangoul	frangoul	ADJ
ajmsi-1760	84	55	,	,	PUNCT
ajmsi-1760	84	56	2021	2021	NUM
ajmsi-1760	84	57	)	)	PUNCT
ajmsi-1760	84	58	crispr	crispr	NOUN
ajmsi-1760	84	59	-	-	PUNCT
ajmsi-1760	84	60	cas9	cas9	NOUN
ajmsi-1760	84	61	-	-	PUNCT
ajmsi-1760	84	62	targeting	target	VERB
ajmsi-1760	84	63	erythroidspecific	erythroidspecific	ADJ
ajmsi-1760	84	64	enhancers	enhancer	NOUN
ajmsi-1760	84	65	modified	modify	VERB
ajmsi-1760	84	66	80	80	NUM
ajmsi-1760	84	67	%	%	NOUN
ajmsi-1760	84	68	of	of	ADP
ajmsi-1760	84	69	the	the	DET
ajmsi-1760	84	70	alleles	allele	NOUN
ajmsi-1760	84	71	at	at	ADP
ajmsi-1760	84	72	this	this	DET
ajmsi-1760	84	73	locus	locus	NOUN
ajmsi-1760	84	74	in	in	ADP
ajmsi-1760	84	75	healthy	healthy	ADJ
ajmsi-1760	84	76	donors	donor	NOUN
ajmsi-1760	84	77	.	.	PUNCT
ajmsi-1760	85	1	phase	phase	NOUN
ajmsi-1760	85	2	½	½	NOUN
ajmsi-1760	85	3	•	•	NOUN
ajmsi-1760	85	4	allelic	allelic	ADJ
ajmsi-1760	85	5	editing	edit	VERB
ajmsi-1760	85	6	in	in	ADP
ajmsi-1760	85	7	bone	bone	NOUN
ajmsi-1760	85	8	marrow	marrow	NOUN
ajmsi-1760	85	9	and	and	CCONJ
ajmsi-1760	85	10	blood	blood	NOUN
ajmsi-1760	85	11	•	•	ADP
ajmsi-1760	85	12	↑	↑	PROPN
ajmsi-1760	85	13	in	in	ADP
ajmsi-1760	85	14	hbf	hbf	PROPN
ajmsi-1760	85	15	•transfusion	•transfusion	PROPN
ajmsi-1760	85	16	independence	independence	NOUN
ajmsi-1760	85	17	•	•	NOUN
ajmsi-1760	85	18	elimination	elimination	NOUN
ajmsi-1760	85	19	of	of	ADP
ajmsi-1760	85	20	vaso	vaso	NOUN
ajmsi-1760	85	21	-	-	PUNCT
ajmsi-1760	85	22	occlusive	occlusive	ADJ
ajmsi-1760	85	23	episodes	episode	NOUN
ajmsi-1760	85	24	in	in	ADP
ajmsi-1760	85	25	the	the	DET
ajmsi-1760	85	26	patient	patient	NOUN
ajmsi-1760	85	27	with	with	ADP
ajmsi-1760	85	28	scd	scd	PROPN
ajmsi-1760	85	29	pa	pa	PROPN
ajmsi-1760	85	30	ge	ge	PROPN
ajmsi-1760	85	31	47	47	NUM
ajmsi-1760	85	32	https://journals.e-palli.com/home/index.php/ajmsi	https://journals.e-palli.com/home/index.php/ajmsi	PROPN
ajmsi-1760	85	33	am	be	AUX
ajmsi-1760	85	34	.	.	PUNCT
ajmsi-1760	86	1	j.	j.	PROPN
ajmsi-1760	86	2	med	med	PROPN
ajmsi-1760	86	3	.	.	PUNCT
ajmsi-1760	87	1	sci	sci	PROPN
ajmsi-1760	87	2	.	.	PUNCT
ajmsi-1760	87	3	innov	innov	PROPN
ajmsi-1760	87	4	.	.	PUNCT
ajmsi-1760	88	1	2(2	2(2	NUM
ajmsi-1760	88	2	)	)	PUNCT
ajmsi-1760	88	3	44	44	NUM
ajmsi-1760	88	4	-	-	SYM
ajmsi-1760	88	5	56	56	NUM
ajmsi-1760	88	6	,	,	PUNCT
ajmsi-1760	88	7	2023	2023	NUM
ajmsi-1760	88	8	2	2	NUM
ajmsi-1760	88	9	a	a	DET
ajmsi-1760	88	10	review	review	NOUN
ajmsi-1760	88	11	of	of	ADP
ajmsi-1760	88	12	the	the	DET
ajmsi-1760	88	13	therapeutic	therapeutic	ADJ
ajmsi-1760	88	14	potential	potential	NOUN
ajmsi-1760	88	15	,	,	PUNCT
ajmsi-1760	88	16	prospects	prospect	NOUN
ajmsi-1760	88	17	,	,	PUNCT
ajmsi-1760	88	18	and	and	CCONJ
ajmsi-1760	88	19	challenges	challenge	NOUN
ajmsi-1760	88	20	of	of	ADP
ajmsi-1760	88	21	crisprcas9	crisprcas9	NOUN
ajmsi-1760	88	22	genome	genome	NOUN
ajmsi-1760	88	23	editing	editing	NOUN
ajmsi-1760	88	24	in	in	ADP
ajmsi-1760	88	25	the	the	DET
ajmsi-1760	88	26	treatment	treatment	NOUN
ajmsi-1760	88	27	of	of	ADP
ajmsi-1760	88	28	sickle	sickle	NOUN
ajmsi-1760	88	29	cell	cell	NOUN
ajmsi-1760	88	30	disease	disease	NOUN
ajmsi-1760	88	31	(	(	PUNCT
ajmsi-1760	88	32	scd	scd	NOUN
ajmsi-1760	88	33	)	)	PUNCT
ajmsi-1760	88	34	(	(	PUNCT
ajmsi-1760	88	35	chaudhary	chaudhary	PROPN
ajmsi-1760	88	36	,	,	PUNCT
ajmsi-1760	88	37	2020	2020	NUM
ajmsi-1760	88	38	)	)	PUNCT
ajmsi-1760	88	39	crispr	crispr	NOUN
ajmsi-1760	88	40	-	-	PUNCT
ajmsi-1760	88	41	cas9	cas9	NOUN
ajmsi-1760	88	42	is	be	AUX
ajmsi-1760	88	43	a	a	DET
ajmsi-1760	88	44	potential	potential	ADJ
ajmsi-1760	88	45	therapeutic	therapeutic	ADJ
ajmsi-1760	88	46	tool	tool	NOUN
ajmsi-1760	88	47	in	in	ADP
ajmsi-1760	88	48	the	the	DET
ajmsi-1760	88	49	management	management	NOUN
ajmsi-1760	88	50	of	of	ADP
ajmsi-1760	88	51	scd	scd	PROPN
ajmsi-1760	88	52	.	.	PUNCT
ajmsi-1760	89	1	review	review	VERB
ajmsi-1760	89	2	•	•	NOUN
ajmsi-1760	89	3	through	through	ADP
ajmsi-1760	89	4	this	this	DET
ajmsi-1760	89	5	review	review	NOUN
ajmsi-1760	89	6	paper	paper	NOUN
ajmsi-1760	89	7	,	,	PUNCT
ajmsi-1760	89	8	the	the	DET
ajmsi-1760	89	9	scope	scope	NOUN
ajmsi-1760	89	10	and	and	CCONJ
ajmsi-1760	89	11	possibilities	possibility	NOUN
ajmsi-1760	89	12	of	of	ADP
ajmsi-1760	89	13	crispr	crispr	NOUN
ajmsi-1760	89	14	-	-	PUNCT
ajmsi-1760	89	15	cas9	cas9	NOUN
ajmsi-1760	89	16	as	as	ADP
ajmsi-1760	89	17	a	a	DET
ajmsi-1760	89	18	potential	potential	ADJ
ajmsi-1760	89	19	therapeutic	therapeutic	ADJ
ajmsi-1760	89	20	tool	tool	NOUN
ajmsi-1760	89	21	in	in	ADP
ajmsi-1760	89	22	the	the	DET
ajmsi-1760	89	23	management	management	NOUN
ajmsi-1760	89	24	of	of	ADP
ajmsi-1760	89	25	scd	scd	PROPN
ajmsi-1760	89	26	was	be	AUX
ajmsi-1760	89	27	analyzed	analyze	VERB
ajmsi-1760	89	28	3	3	NUM
ajmsi-1760	89	29	therapeutic	therapeutic	ADJ
ajmsi-1760	89	30	crisprcas9	crisprcas9	NOUN
ajmsi-1760	89	31	genome	genome	NOUN
ajmsi-1760	89	32	editing	editing	NOUN
ajmsi-1760	89	33	for	for	ADP
ajmsi-1760	89	34	treating	treat	VERB
ajmsi-1760	89	35	sickle	sickle	NOUN
ajmsi-1760	89	36	cell	cell	NOUN
ajmsi-1760	89	37	disease	disease	NOUN
ajmsi-1760	89	38	(	(	PUNCT
ajmsi-1760	89	39	park	park	NOUN
ajmsi-1760	89	40	,	,	PUNCT
ajmsi-1760	89	41	2016	2016	NUM
ajmsi-1760	89	42	)	)	PUNCT
ajmsi-1760	89	43	optimized	optimize	VERB
ajmsi-1760	89	44	crispr	crispr	ADJ
ajmsi-1760	89	45	-	-	PUNCT
ajmsi-1760	89	46	cas9	cas9	NOUN
ajmsi-1760	89	47	systems	system	NOUN
ajmsi-1760	89	48	for	for	ADP
ajmsi-1760	89	49	genomic	genomic	NOUN
ajmsi-1760	89	50	editing	editing	NOUN
ajmsi-1760	89	51	can	can	AUX
ajmsi-1760	89	52	be	be	AUX
ajmsi-1760	89	53	achieved	achieve	VERB
ajmsi-1760	89	54	in	in	ADP
ajmsi-1760	89	55	cd34	cd34	PROPN
ajmsi-1760	89	56	+	+	CCONJ
ajmsi-1760	89	57	cells	cell	NOUN
ajmsi-1760	89	58	.	.	PUNCT
ajmsi-1760	90	1	review	review	VERB
ajmsi-1760	90	2	•	•	NUM
ajmsi-1760	90	3	rates	rate	NOUN
ajmsi-1760	90	4	of	of	ADP
ajmsi-1760	90	5	non	non	ADJ
ajmsi-1760	90	6	-	-	ADJ
ajmsi-1760	90	7	homologous	homologous	ADJ
ajmsi-1760	90	8	end	end	NOUN
ajmsi-1760	90	9	joining	join	VERB
ajmsi-1760	90	10	(	(	PUNCT
ajmsi-1760	90	11	nhej	nhej	ADJ
ajmsi-1760	90	12	)	)	PUNCT
ajmsi-1760	90	13	events	event	NOUN
ajmsi-1760	91	1	•	•	NOUN
ajmsi-1760	91	2	rates	rate	NOUN
ajmsi-1760	91	3	of	of	ADP
ajmsi-1760	91	4	homology	homology	NOUN
ajmsi-1760	91	5	directed	direct	VERB
ajmsi-1760	91	6	repair	repair	NOUN
ajmsi-1760	91	7	(	(	PUNCT
ajmsi-1760	91	8	hdr	hdr	NOUN
ajmsi-1760	91	9	)	)	PUNCT
ajmsi-1760	91	10	events	event	NOUN
ajmsi-1760	91	11	•	•	NOUN
ajmsi-1760	91	12	genome	genome	NOUN
ajmsi-1760	91	13	editing	editing	NOUN
ajmsi-1760	91	14	frequencies	frequency	NOUN
ajmsi-1760	91	15	at	at	ADP
ajmsi-1760	91	16	both	both	CCONJ
ajmsi-1760	91	17	dna	dna	PROPN
ajmsi-1760	91	18	and	and	CCONJ
ajmsi-1760	91	19	mrna	mrna	PROPN
ajmsi-1760	91	20	levels	level	NOUN
ajmsi-1760	91	21	•	•	ADP
ajmsi-1760	91	22	expression	expression	NOUN
ajmsi-1760	91	23	of	of	ADP
ajmsi-1760	91	24	globin	globin	NOUN
ajmsi-1760	91	25	and	and	CCONJ
ajmsi-1760	91	26	other	other	ADJ
ajmsi-1760	91	27	erythroid	erythroid	ADJ
ajmsi-1760	91	28	markers	marker	NOUN
ajmsi-1760	91	29	•	•	ADJ
ajmsi-1760	91	30	number	number	NOUN
ajmsi-1760	91	31	and	and	CCONJ
ajmsi-1760	91	32	type	type	NOUN
ajmsi-1760	91	33	of	of	ADP
ajmsi-1760	91	34	colonies	colony	NOUN
ajmsi-1760	91	35	following	follow	VERB
ajmsi-1760	91	36	induction	induction	NOUN
ajmsi-1760	91	37	of	of	ADP
ajmsi-1760	91	38	differentiation	differentiation	NOUN
ajmsi-1760	91	39	•	•	NOUN
ajmsi-1760	91	40	genotype	genotype	NOUN
ajmsi-1760	91	41	of	of	ADP
ajmsi-1760	91	42	edited	edited	ADJ
ajmsi-1760	91	43	cells	cell	NOUN
ajmsi-1760	91	44	•	•	PRON
ajmsi-1760	91	45	translation	translation	NOUN
ajmsi-1760	91	46	of	of	ADP
ajmsi-1760	91	47	edited	edited	ADJ
ajmsi-1760	91	48	β	β	NOUN
ajmsi-1760	91	49	-	-	ADJ
ajmsi-1760	91	50	globin	globin	ADJ
ajmsi-1760	91	51	protein	protein	NOUN
ajmsi-1760	91	52	and	and	CCONJ
ajmsi-1760	91	53	formation	formation	NOUN
ajmsi-1760	91	54	of	of	ADP
ajmsi-1760	91	55	hbs	hbs	PROPN
ajmsi-1760	91	56	4	4	NUM
ajmsi-1760	91	57	crispr	crispr	ADJ
ajmsi-1760	91	58	-	-	PUNCT
ajmsi-1760	91	59	cas9	cas9	NOUN
ajmsi-1760	91	60	mediated	mediate	VERB
ajmsi-1760	91	61	correction	correction	NOUN
ajmsi-1760	91	62	of	of	ADP
ajmsi-1760	91	63	the	the	DET
ajmsi-1760	91	64	sickle	sickle	NOUN
ajmsi-1760	91	65	mutation	mutation	NOUN
ajmsi-1760	91	66	in	in	ADP
ajmsi-1760	91	67	human	human	ADJ
ajmsi-1760	91	68	cd34	cd34	PROPN
ajmsi-1760	91	69	+	+	PROPN
ajmsi-1760	91	70	cells	cell	NOUN
ajmsi-1760	91	71	(	(	PUNCT
ajmsi-1760	91	72	hoban	hoban	NOUN
ajmsi-1760	91	73	,	,	PUNCT
ajmsi-1760	91	74	2016a	2016a	NUM
ajmsi-1760	91	75	)	)	PUNCT
ajmsi-1760	91	76	targeted	target	VERB
ajmsi-1760	91	77	genomic	genomic	NOUN
ajmsi-1760	91	78	editing	editing	NOUN
ajmsi-1760	91	79	technology	technology	NOUN
ajmsi-1760	91	80	can	can	AUX
ajmsi-1760	91	81	correct	correct	VERB
ajmsi-1760	91	82	the	the	DET
ajmsi-1760	91	83	scd	scd	NOUN
ajmsi-1760	91	84	mutation	mutation	NOUN
ajmsi-1760	91	85	of	of	ADP
ajmsi-1760	91	86	the	the	DET
ajmsi-1760	91	87	β	β	NOUN
ajmsi-1760	91	88	-	-	ADJ
ajmsi-1760	91	89	globin	globin	ADJ
ajmsi-1760	91	90	gene	gene	NOUN
ajmsi-1760	91	91	in	in	ADP
ajmsi-1760	91	92	hematopoietic	hematopoietic	ADJ
ajmsi-1760	91	93	stem	stem	NOUN
ajmsi-1760	91	94	cells	cell	NOUN
ajmsi-1760	91	95	.	.	PUNCT
ajmsi-1760	92	1	e	e	NOUN
ajmsi-1760	92	2	xperim	xperim	VERB
ajmsi-1760	92	3	ental	ental	ADJ
ajmsi-1760	92	4	•	•	NUM
ajmsi-1760	92	5	gene	gene	NOUN
ajmsi-1760	92	6	modification	modification	NOUN
ajmsi-1760	92	7	rate	rate	NOUN
ajmsi-1760	92	8	•	•	NOUN
ajmsi-1760	92	9	production	production	NOUN
ajmsi-1760	92	10	of	of	ADP
ajmsi-1760	92	11	wild	wild	ADJ
ajmsi-1760	92	12	type	type	NOUN
ajmsi-1760	92	13	hemoglobin	hemoglobin	NOUN
ajmsi-1760	92	14	.	.	PUNCT
ajmsi-1760	93	1	5	5	NUM
ajmsi-1760	93	2	crispr	crispr	ADJ
ajmsi-1760	93	3	-	-	PUNCT
ajmsi-1760	93	4	cas9	cas9	NOUN
ajmsi-1760	93	5	to	to	PART
ajmsi-1760	93	6	induce	induce	VERB
ajmsi-1760	93	7	fetal	fetal	ADJ
ajmsi-1760	93	8	hemoglobin	hemoglobin	NOUN
ajmsi-1760	93	9	for	for	ADP
ajmsi-1760	93	10	the	the	DET
ajmsi-1760	93	11	treatment	treatment	NOUN
ajmsi-1760	93	12	of	of	ADP
ajmsi-1760	93	13	sickle	sickle	NOUN
ajmsi-1760	93	14	cell	cell	NOUN
ajmsi-1760	93	15	disease	disease	NOUN
ajmsi-1760	93	16	(	(	PUNCT
ajmsi-1760	93	17	demirci	demirci	NOUN
ajmsi-1760	93	18	,	,	PUNCT
ajmsi-1760	93	19	2021	2021	NUM
ajmsi-1760	93	20	)	)	PUNCT
ajmsi-1760	93	21	genomic	genomic	NOUN
ajmsi-1760	93	22	editing	editing	NOUN
ajmsi-1760	93	23	is	be	AUX
ajmsi-1760	93	24	potentially	potentially	ADV
ajmsi-1760	93	25	a	a	DET
ajmsi-1760	93	26	curative	curative	ADJ
ajmsi-1760	93	27	technique	technique	NOUN
ajmsi-1760	93	28	available	available	ADJ
ajmsi-1760	93	29	to	to	ADP
ajmsi-1760	93	30	all	all	DET
ajmsi-1760	93	31	individuals	individual	NOUN
ajmsi-1760	93	32	with	with	ADP
ajmsi-1760	93	33	-hemoglobinopathies	-hemoglobinopathie	NOUN
ajmsi-1760	93	34	,	,	PUNCT
ajmsi-1760	93	35	including	include	VERB
ajmsi-1760	93	36	scd	scd	PROPN
ajmsi-1760	93	37	.	.	PUNCT
ajmsi-1760	94	1	review	review	NOUN
ajmsi-1760	94	2	•	•	NUM
ajmsi-1760	94	3	fetal	fetal	ADJ
ajmsi-1760	94	4	hemoglobin	hemoglobin	NOUN
ajmsi-1760	94	5	(	(	PUNCT
ajmsi-1760	94	6	hbf	hbf	PROPN
ajmsi-1760	94	7	)	)	PUNCT
ajmsi-1760	94	8	induction	induction	NOUN
ajmsi-1760	94	9	•	•	NOUN
ajmsi-1760	94	10	editing	editing	NOUN
ajmsi-1760	94	11	of	of	ADP
ajmsi-1760	94	12	transcriptional	transcriptional	ADJ
ajmsi-1760	94	13	hbf	hbf	PROPN
ajmsi-1760	94	14	silencers	silencer	NOUN
ajmsi-1760	94	15	•	•	ADV
ajmsi-1760	94	16	modulating	modulate	VERB
ajmsi-1760	94	17	epigenetic	epigenetic	ADJ
ajmsi-1760	94	18	intermediates	intermediate	NOUN
ajmsi-1760	94	19	that	that	PRON
ajmsi-1760	94	20	govern	govern	VERB
ajmsi-1760	94	21	hbf	hbf	NOUN
ajmsi-1760	94	22	expression	expression	NOUN
ajmsi-1760	94	23	6	6	NUM
ajmsi-1760	94	24	crispr	crispr	NOUN
ajmsi-1760	94	25	-	-	PUNCT
ajmsi-1760	94	26	cas9	cas9	NOUN
ajmsi-1760	94	27	for	for	ADP
ajmsi-1760	94	28	sickle	sickle	NOUN
ajmsi-1760	94	29	cell	cell	NOUN
ajmsi-1760	94	30	disease	disease	NOUN
ajmsi-1760	94	31	:	:	PUNCT
ajmsi-1760	94	32	applications	application	NOUN
ajmsi-1760	94	33	,	,	PUNCT
ajmsi-1760	94	34	future	future	ADJ
ajmsi-1760	94	35	possibilities	possibility	NOUN
ajmsi-1760	94	36	,	,	PUNCT
ajmsi-1760	94	37	and	and	CCONJ
ajmsi-1760	94	38	challenges	challenge	NOUN
ajmsi-1760	94	39	(	(	PUNCT
ajmsi-1760	94	40	demirci	demirci	NOUN
ajmsi-1760	94	41	,	,	PUNCT
ajmsi-1760	94	42	2019	2019	NUM
ajmsi-1760	94	43	)	)	PUNCT
ajmsi-1760	94	44	genomic	genomic	NOUN
ajmsi-1760	94	45	editing	editing	NOUN
ajmsi-1760	94	46	approach	approach	NOUN
ajmsi-1760	94	47	has	have	AUX
ajmsi-1760	94	48	proven	prove	VERB
ajmsi-1760	94	49	valuable	valuable	ADJ
ajmsi-1760	94	50	as	as	ADP
ajmsi-1760	94	51	a	a	DET
ajmsi-1760	94	52	curative	curative	ADJ
ajmsi-1760	94	53	option	option	NOUN
ajmsi-1760	94	54	.	.	PUNCT
ajmsi-1760	95	1	review	review	NOUN
ajmsi-1760	95	2	•	•	NUM
ajmsi-1760	95	3	disease	disease	NOUN
ajmsi-1760	95	4	severity	severity	NOUN
ajmsi-1760	95	5	•	•	NUM
ajmsi-1760	95	6	mortality	mortality	NOUN
ajmsi-1760	95	7	•	•	NOUN
ajmsi-1760	95	8	morbidity	morbidity	NOUN
ajmsi-1760	95	9	7	7	NUM
ajmsi-1760	95	10	crispr	crispr	ADJ
ajmsi-1760	95	11	-	-	PUNCT
ajmsi-1760	95	12	cas9	cas9	NOUN
ajmsi-1760	95	13	gene	gene	NOUN
ajmsi-1760	95	14	editing	edit	VERB
ajmsi-1760	95	15	for	for	ADP
ajmsi-1760	95	16	curing	cure	VERB
ajmsi-1760	95	17	sickle	sickle	NOUN
ajmsi-1760	95	18	cell	cell	NOUN
ajmsi-1760	95	19	disease	disease	NOUN
ajmsi-1760	95	20	(	(	PUNCT
ajmsi-1760	95	21	park	park	NOUN
ajmsi-1760	95	22	,	,	PUNCT
ajmsi-1760	95	23	2021a	2021a	NUM
ajmsi-1760	95	24	)	)	PUNCT
ajmsi-1760	95	25	ex	ex	PRON
ajmsi-1760	95	26	vivo	vivo	ADJ
ajmsi-1760	95	27	engineering	engineering	NOUN
ajmsi-1760	95	28	of	of	ADP
ajmsi-1760	95	29	autologous	autologous	ADJ
ajmsi-1760	95	30	hspcs	hspc	NOUN
ajmsi-1760	95	31	followed	follow	VERB
ajmsi-1760	95	32	by	by	ADP
ajmsi-1760	95	33	transplantation	transplantation	NOUN
ajmsi-1760	95	34	of	of	ADP
ajmsi-1760	95	35	genetically	genetically	ADV
ajmsi-1760	95	36	modified	modify	VERB
ajmsi-1760	95	37	cells	cell	NOUN
ajmsi-1760	95	38	potentially	potentially	ADV
ajmsi-1760	95	39	provides	provide	VERB
ajmsi-1760	95	40	a	a	DET
ajmsi-1760	95	41	permanent	permanent	ADJ
ajmsi-1760	95	42	cure	cure	NOUN
ajmsi-1760	95	43	applicable	applicable	ADJ
ajmsi-1760	95	44	to	to	ADP
ajmsi-1760	95	45	all	all	DET
ajmsi-1760	95	46	patients	patient	NOUN
ajmsi-1760	95	47	regardless	regardless	ADV
ajmsi-1760	95	48	of	of	ADP
ajmsi-1760	95	49	the	the	DET
ajmsi-1760	95	50	availability	availability	NOUN
ajmsi-1760	95	51	of	of	ADP
ajmsi-1760	95	52	suitable	suitable	ADJ
ajmsi-1760	95	53	donors	donor	NOUN
ajmsi-1760	95	54	and	and	CCONJ
ajmsi-1760	95	55	graft	graft	NOUN
ajmsi-1760	95	56	-	-	PUNCT
ajmsi-1760	95	57	vs	vs	ADP
ajmsi-1760	95	58	-	-	PUNCT
ajmsi-1760	95	59	host	host	NOUN
ajmsi-1760	95	60	reaction	reaction	NOUN
ajmsi-1760	95	61	.	.	PUNCT
ajmsi-1760	96	1	review	review	NOUN
ajmsi-1760	96	2	•	•	NUM
ajmsi-1760	96	3	severity	severity	NOUN
ajmsi-1760	96	4	of	of	ADP
ajmsi-1760	96	5	pain	pain	NOUN
ajmsi-1760	96	6	•	•	ADP
ajmsi-1760	96	7	end	end	NOUN
ajmsi-1760	96	8	organ	organ	NOUN
ajmsi-1760	96	9	damage	damage	NOUN
ajmsi-1760	96	10	•	•	ADP
ajmsi-1760	96	11	early	early	ADJ
ajmsi-1760	96	12	mortality	mortality	NOUN
ajmsi-1760	96	13	8	8	NUM
ajmsi-1760	96	14	crispr	crispr	ADJ
ajmsi-1760	96	15	-	-	PUNCT
ajmsi-1760	96	16	cas9	cas9	NOUN
ajmsi-1760	96	17	genomic	genomic	NOUN
ajmsi-1760	96	18	engineering	engineering	NOUN
ajmsi-1760	96	19	:	:	PUNCT
ajmsi-1760	96	20	trends	trend	NOUN
ajmsi-1760	96	21	in	in	ADP
ajmsi-1760	96	22	medicine	medicine	NOUN
ajmsi-1760	96	23	and	and	CCONJ
ajmsi-1760	96	24	health	health	NOUN
ajmsi-1760	96	25	(	(	PUNCT
ajmsi-1760	96	26	zaib	zaib	NOUN
ajmsi-1760	96	27	,	,	PUNCT
ajmsi-1760	96	28	2022	2022	NUM
ajmsi-1760	96	29	)	)	PUNCT
ajmsi-1760	96	30	crispr	crispr	ADJ
ajmsi-1760	96	31	-	-	PUNCT
ajmsi-1760	96	32	cas9	cas9	NOUN
ajmsi-1760	96	33	technology	technology	NOUN
ajmsi-1760	96	34	offers	offer	VERB
ajmsi-1760	96	35	the	the	DET
ajmsi-1760	96	36	simplest	simple	ADJ
ajmsi-1760	96	37	,	,	PUNCT
ajmsi-1760	96	38	fastest	fast	ADJ
ajmsi-1760	96	39	,	,	PUNCT
ajmsi-1760	96	40	most	most	ADV
ajmsi-1760	96	41	versatile	versatile	ADJ
ajmsi-1760	96	42	,	,	PUNCT
ajmsi-1760	96	43	reliable	reliable	ADJ
ajmsi-1760	96	44	and	and	CCONJ
ajmsi-1760	96	45	precise	precise	ADJ
ajmsi-1760	96	46	method	method	NOUN
ajmsi-1760	96	47	of	of	ADP
ajmsi-1760	96	48	genetic	genetic	ADJ
ajmsi-1760	96	49	manipulation	manipulation	NOUN
ajmsi-1760	96	50	.	.	PUNCT
ajmsi-1760	97	1	review	review	VERB
ajmsi-1760	97	2	•	•	NUM
ajmsi-1760	97	3	genetic	genetic	ADJ
ajmsi-1760	97	4	manipulation	manipulation	NOUN
ajmsi-1760	97	5	•	•	ADV
ajmsi-1760	97	6	removing	remove	VERB
ajmsi-1760	97	7	sections	section	NOUN
ajmsi-1760	97	8	of	of	ADP
ajmsi-1760	97	9	the	the	DET
ajmsi-1760	97	10	dna	dna	PROPN
ajmsi-1760	97	11	sequence	sequence	NOUN
ajmsi-1760	97	12	•	•	NOUN
ajmsi-1760	97	13	adding	add	VERB
ajmsi-1760	97	14	sections	section	NOUN
ajmsi-1760	97	15	of	of	ADP
ajmsi-1760	97	16	the	the	DET
ajmsi-1760	97	17	dna	dna	PROPN
ajmsi-1760	97	18	sequence	sequence	NOUN
ajmsi-1760	97	19	•	•	NOUN
ajmsi-1760	97	20	altering	alter	VERB
ajmsi-1760	97	21	sections	section	NOUN
ajmsi-1760	97	22	of	of	ADP
ajmsi-1760	97	23	the	the	DET
ajmsi-1760	97	24	dna	dna	PROPN
ajmsi-1760	97	25	sequence	sequence	NOUN
ajmsi-1760	97	26	pa	pa	PROPN
ajmsi-1760	97	27	ge	ge	PROPN
ajmsi-1760	97	28	48	48	NUM
ajmsi-1760	97	29	https://journals.e-palli.com/home/index.php/ajmsi	https://journals.e-palli.com/home/index.php/ajmsi	PROPN
ajmsi-1760	97	30	am	be	AUX
ajmsi-1760	97	31	.	.	PUNCT
ajmsi-1760	98	1	j.	j.	PROPN
ajmsi-1760	98	2	med	med	PROPN
ajmsi-1760	98	3	.	.	PUNCT
ajmsi-1760	99	1	sci	sci	PROPN
ajmsi-1760	99	2	.	.	PUNCT
ajmsi-1760	99	3	innov	innov	PROPN
ajmsi-1760	99	4	.	.	PUNCT
ajmsi-1760	100	1	2(2	2(2	NUM
ajmsi-1760	100	2	)	)	PUNCT
ajmsi-1760	100	3	44	44	NUM
ajmsi-1760	100	4	-	-	SYM
ajmsi-1760	100	5	56	56	NUM
ajmsi-1760	100	6	,	,	PUNCT
ajmsi-1760	101	1	2023	2023	NUM
ajmsi-1760	101	2	•	•	NUM
ajmsi-1760	101	3	treatment	treatment	NOUN
ajmsi-1760	101	4	of	of	ADP
ajmsi-1760	101	5	various	various	ADJ
ajmsi-1760	101	6	medical	medical	ADJ
ajmsi-1760	101	7	conditions	condition	NOUN
ajmsi-1760	101	8	including	include	VERB
ajmsi-1760	101	9	cancer	cancer	NOUN
ajmsi-1760	101	10	,	,	PUNCT
ajmsi-1760	101	11	hepatitis	hepatitis	NOUN
ajmsi-1760	101	12	b	b	NOUN
ajmsi-1760	101	13	,	,	PUNCT
ajmsi-1760	101	14	cardiovascular	cardiovascular	ADJ
ajmsi-1760	101	15	diseases	disease	NOUN
ajmsi-1760	101	16	or	or	CCONJ
ajmsi-1760	101	17	even	even	ADV
ajmsi-1760	101	18	high	high	ADJ
ajmsi-1760	101	19	cholesterol	cholesterol	NOUN
ajmsi-1760	101	20	•	•	NOUN
ajmsi-1760	101	21	minimization	minimization	NOUN
ajmsi-1760	101	22	of	of	ADP
ajmsi-1760	101	23	the	the	DET
ajmsi-1760	101	24	off	off	ADP
ajmsi-1760	101	25	-	-	PUNCT
ajmsi-1760	101	26	target	target	NOUN
ajmsi-1760	101	27	effects	effect	NOUN
ajmsi-1760	101	28	of	of	ADP
ajmsi-1760	101	29	gene	gene	NOUN
ajmsi-1760	101	30	editing	editing	NOUN
ajmsi-1760	101	31	and	and	CCONJ
ajmsi-1760	101	32	incomplete	incomplete	ADJ
ajmsi-1760	101	33	matches	match	NOUN
ajmsi-1760	101	34	between	between	ADP
ajmsi-1760	101	35	single	single	ADJ
ajmsi-1760	101	36	guiderna	guiderna	NOUN
ajmsi-1760	101	37	and	and	CCONJ
ajmsi-1760	101	38	genomic	genomic	ADJ
ajmsi-1760	101	39	dna	dna	NOUN
ajmsi-1760	101	40	by	by	ADP
ajmsi-1760	101	41	cas9	cas9	NOUN
ajmsi-1760	101	42	9	9	NUM
ajmsi-1760	101	43	crispr	crispr	NOUN
ajmsi-1760	101	44	-	-	PUNCT
ajmsi-1760	101	45	cas9	cas9	NOUN
ajmsi-1760	101	46	:	:	PUNCT
ajmsi-1760	101	47	anew	anew	PROPN
ajmsi-1760	101	48	and	and	CCONJ
ajmsi-1760	101	49	promising	promising	ADJ
ajmsi-1760	101	50	player	player	NOUN
ajmsi-1760	101	51	in	in	ADP
ajmsi-1760	101	52	gene	gene	NOUN
ajmsi-1760	101	53	therapy	therapy	NOUN
ajmsi-1760	101	54	(	(	PUNCT
ajmsi-1760	101	55	xiao	xiao	PROPN
ajmsi-1760	101	56	-	-	PUNCT
ajmsi-1760	101	57	jie	jie	PROPN
ajmsi-1760	101	58	,	,	PUNCT
ajmsi-1760	101	59	2015	2015	NUM
ajmsi-1760	101	60	)	)	PUNCT
ajmsi-1760	101	61	crispr	crispr	NOUN
ajmsi-1760	101	62	-	-	PUNCT
ajmsi-1760	101	63	cas9	cas9	NOUN
ajmsi-1760	101	64	can	can	AUX
ajmsi-1760	101	65	be	be	AUX
ajmsi-1760	101	66	applied	apply	VERB
ajmsi-1760	101	67	for	for	ADP
ajmsi-1760	101	68	therapeutic	therapeutic	ADJ
ajmsi-1760	101	69	purposes	purpose	NOUN
ajmsi-1760	101	70	in	in	ADP
ajmsi-1760	101	71	cell	cell	NOUN
ajmsi-1760	101	72	lines	line	NOUN
ajmsi-1760	101	73	or	or	CCONJ
ajmsi-1760	101	74	animal	animal	NOUN
ajmsi-1760	101	75	models	model	NOUN
ajmsi-1760	101	76	.	.	PUNCT
ajmsi-1760	102	1	review	review	VERB
ajmsi-1760	102	2	•	•	NUM
ajmsi-1760	102	3	gene	gene	NOUN
ajmsi-1760	102	4	therapy	therapy	NOUN
ajmsi-1760	102	5	outcomes	outcome	NOUN
ajmsi-1760	102	6	•	•	ADP
ajmsi-1760	102	7	correction	correction	NOUN
ajmsi-1760	102	8	of	of	ADP
ajmsi-1760	102	9	causal	causal	ADJ
ajmsi-1760	102	10	mutations	mutation	NOUN
ajmsi-1760	102	11	in	in	ADP
ajmsi-1760	102	12	monogenic	monogenic	ADJ
ajmsi-1760	102	13	disorders	disorder	NOUN
ajmsi-1760	102	14	•	•	ADP
ajmsi-1760	102	15	rescue	rescue	NOUN
ajmsi-1760	102	16	of	of	ADP
ajmsi-1760	102	17	disease	disease	NOUN
ajmsi-1760	102	18	phenotypes	phenotypes	NOUN
ajmsi-1760	102	19	•	•	NOUN
ajmsi-1760	102	20	engineering	engineering	NOUN
ajmsi-1760	102	21	of	of	ADP
ajmsi-1760	102	22	pathogen	pathogen	NOUN
ajmsi-1760	102	23	genome	genome	NOUN
ajmsi-1760	102	24	for	for	ADP
ajmsi-1760	102	25	therapeutic	therapeutic	ADJ
ajmsi-1760	102	26	purposes	purpose	NOUN
ajmsi-1760	102	27	•	•	PRON
ajmsi-1760	102	28	induction	induction	NOUN
ajmsi-1760	102	29	of	of	ADP
ajmsi-1760	102	30	protective	protective	ADJ
ajmsi-1760	102	31	or	or	CCONJ
ajmsi-1760	102	32	therapeutic	therapeutic	ADJ
ajmsi-1760	102	33	mutations	mutation	NOUN
ajmsi-1760	102	34	in	in	ADP
ajmsi-1760	102	35	host	host	NOUN
ajmsi-1760	102	36	tissues	tissue	NOUN
ajmsi-1760	102	37	•	•	ADP
ajmsi-1760	102	38	deactivation	deactivation	NOUN
ajmsi-1760	102	39	of	of	ADP
ajmsi-1760	102	40	oncogenic	oncogenic	ADJ
ajmsi-1760	102	41	virus	virus	NOUN
ajmsi-1760	102	42	•	•	NOUN
ajmsi-1760	102	43	induction	induction	NOUN
ajmsi-1760	102	44	of	of	ADP
ajmsi-1760	102	45	onco	onco	NOUN
ajmsi-1760	102	46	-	-	PUNCT
ajmsi-1760	102	47	suppressor	suppressor	NOUN
ajmsi-1760	102	48	expressions	expression	NOUN
ajmsi-1760	102	49	10	10	NUM
ajmsi-1760	102	50	emerging	emerge	VERB
ajmsi-1760	102	51	genetic	genetic	ADJ
ajmsi-1760	102	52	therapy	therapy	NOUN
ajmsi-1760	102	53	for	for	ADP
ajmsi-1760	102	54	sickle	sickle	NOUN
ajmsi-1760	102	55	cell	cell	NOUN
ajmsi-1760	102	56	disease	disease	NOUN
ajmsi-1760	102	57	(	(	PUNCT
ajmsi-1760	102	58	orkin	orkin	PROPN
ajmsi-1760	102	59	,	,	PUNCT
ajmsi-1760	102	60	2019	2019	NUM
ajmsi-1760	102	61	)	)	PUNCT
ajmsi-1760	102	62	transcript	transcript	NOUN
ajmsi-1760	102	63	factors	factor	NOUN
ajmsi-1760	102	64	that	that	PRON
ajmsi-1760	102	65	mediate	mediate	VERB
ajmsi-1760	102	66	silencing	silence	VERB
ajmsi-1760	102	67	of	of	ADP
ajmsi-1760	102	68	the	the	DET
ajmsi-1760	102	69	γ	γ	PROPN
ajmsi-1760	102	70	-	-	PUNCT
ajmsi-1760	102	71	like	like	ADJ
ajmsi-1760	102	72	fetal	fetal	ADJ
ajmsi-1760	102	73	globin	globin	NOUN
ajmsi-1760	102	74	gene	gene	NOUN
ajmsi-1760	102	75	after	after	ADP
ajmsi-1760	102	76	birth	birth	NOUN
ajmsi-1760	102	77	have	have	AUX
ajmsi-1760	102	78	been	be	AUX
ajmsi-1760	102	79	identified	identify	VERB
ajmsi-1760	102	80	and	and	CCONJ
ajmsi-1760	102	81	demonstrated	demonstrate	VERB
ajmsi-1760	102	82	to	to	PART
ajmsi-1760	102	83	act	act	VERB
ajmsi-1760	102	84	as	as	ADP
ajmsi-1760	102	85	the	the	DET
ajmsi-1760	102	86	β	β	NOUN
ajmsi-1760	102	87	-	-	ADJ
ajmsi-1760	102	88	globin	globin	ADJ
ajmsi-1760	102	89	promoters	promoter	NOUN
ajmsi-1760	102	90	.	.	PUNCT
ajmsi-1760	103	1	review	review	VERB
ajmsi-1760	103	2	•	•	NUM
ajmsi-1760	103	3	efficacy	efficacy	NOUN
ajmsi-1760	103	4	of	of	ADP
ajmsi-1760	103	5	genetic	genetic	ADJ
ajmsi-1760	103	6	strategies	strategy	NOUN
ajmsi-1760	103	7	to	to	PART
ajmsi-1760	103	8	cure	cure	VERB
ajmsi-1760	103	9	scd	scd	NOUN
ajmsi-1760	103	10	•	•	NOUN
ajmsi-1760	103	11	safety	safety	NOUN
ajmsi-1760	103	12	of	of	ADP
ajmsi-1760	103	13	genetic	genetic	ADJ
ajmsi-1760	103	14	approaches	approach	NOUN
ajmsi-1760	103	15	to	to	PART
ajmsi-1760	103	16	cure	cure	VERB
ajmsi-1760	103	17	scd	scd	PROPN
ajmsi-1760	103	18	11	11	NUM
ajmsi-1760	103	19	era	era	NOUN
ajmsi-1760	103	20	of	of	ADP
ajmsi-1760	103	21	genomic	genomic	ADJ
ajmsi-1760	103	22	medicine	medicine	NOUN
ajmsi-1760	103	23	:	:	PUNCT
ajmsi-1760	103	24	a	a	DET
ajmsi-1760	103	25	narrative	narrative	ADJ
ajmsi-1760	103	26	review	review	NOUN
ajmsi-1760	103	27	on	on	ADP
ajmsi-1760	103	28	crispr	crispr	ADJ
ajmsi-1760	103	29	technology	technology	NOUN
ajmsi-1760	103	30	as	as	ADP
ajmsi-1760	103	31	a	a	DET
ajmsi-1760	103	32	potential	potential	ADJ
ajmsi-1760	103	33	therapeutic	therapeutic	ADJ
ajmsi-1760	103	34	tool	tool	NOUN
ajmsi-1760	103	35	for	for	ADP
ajmsi-1760	103	36	human	human	ADJ
ajmsi-1760	103	37	diseases	disease	NOUN
ajmsi-1760	103	38	(	(	PUNCT
ajmsi-1760	103	39	kotagama	kotagama	PROPN
ajmsi-1760	103	40	,	,	PUNCT
ajmsi-1760	103	41	2019	2019	NUM
ajmsi-1760	103	42	)	)	PUNCT
ajmsi-1760	103	43	the	the	DET
ajmsi-1760	103	44	guiderna	guiderna	NOUN
ajmsi-1760	103	45	can	can	AUX
ajmsi-1760	103	46	be	be	AUX
ajmsi-1760	103	47	modified	modify	VERB
ajmsi-1760	103	48	to	to	PART
ajmsi-1760	103	49	match	match	VERB
ajmsi-1760	103	50	a	a	DET
ajmsi-1760	103	51	dna	dna	NOUN
ajmsi-1760	103	52	sequence	sequence	NOUN
ajmsi-1760	103	53	of	of	ADP
ajmsi-1760	103	54	interest	interest	NOUN
ajmsi-1760	103	55	in	in	ADP
ajmsi-1760	103	56	the	the	DET
ajmsi-1760	103	57	cell	cell	NOUN
ajmsi-1760	103	58	.	.	PUNCT
ajmsi-1760	104	1	review	review	VERB
ajmsi-1760	104	2	•	•	ADP
ajmsi-1760	104	3	an	an	DET
ajmsi-1760	104	4	insight	insight	NOUN
ajmsi-1760	104	5	with	with	ADP
ajmsi-1760	104	6	relation	relation	NOUN
ajmsi-1760	104	7	to	to	ADP
ajmsi-1760	104	8	a	a	DET
ajmsi-1760	104	9	few	few	ADJ
ajmsi-1760	104	10	of	of	ADP
ajmsi-1760	104	11	the	the	DET
ajmsi-1760	104	12	many	many	ADJ
ajmsi-1760	104	13	diseases	disease	NOUN
ajmsi-1760	104	14	that	that	PRON
ajmsi-1760	104	15	are	be	AUX
ajmsi-1760	104	16	being	be	AUX
ajmsi-1760	104	17	tackled	tackle	VERB
ajmsi-1760	104	18	with	with	ADP
ajmsi-1760	104	19	the	the	DET
ajmsi-1760	104	20	aid	aid	NOUN
ajmsi-1760	104	21	of	of	ADP
ajmsi-1760	104	22	the	the	DET
ajmsi-1760	104	23	crispr	crispr	ADJ
ajmsi-1760	104	24	-	-	PUNCT
ajmsi-1760	104	25	cas9	cas9	NOUN
ajmsi-1760	104	26	mechanism	mechanism	NOUN
ajmsi-1760	104	27	and	and	CCONJ
ajmsi-1760	104	28	the	the	DET
ajmsi-1760	104	29	trends	trend	NOUN
ajmsi-1760	104	30	,	,	PUNCT
ajmsi-1760	104	31	successes	success	NOUN
ajmsi-1760	104	32	,	,	PUNCT
ajmsi-1760	104	33	and	and	CCONJ
ajmsi-1760	104	34	challenges	challenge	NOUN
ajmsi-1760	104	35	of	of	ADP
ajmsi-1760	104	36	this	this	DET
ajmsi-1760	104	37	application	application	NOUN
ajmsi-1760	104	38	as	as	ADP
ajmsi-1760	104	39	a	a	DET
ajmsi-1760	104	40	gene	gene	NOUN
ajmsi-1760	104	41	therapy	therapy	NOUN
ajmsi-1760	104	42	are	be	AUX
ajmsi-1760	104	43	discussed	discuss	VERB
ajmsi-1760	104	44	in	in	ADP
ajmsi-1760	104	45	this	this	DET
ajmsi-1760	104	46	review	review	NOUN
ajmsi-1760	104	47	12	12	NUM
ajmsi-1760	104	48	crispr	crispr	ADJ
ajmsi-1760	104	49	-	-	PUNCT
ajmsi-1760	104	50	cas9	cas9	NOUN
ajmsi-1760	104	51	genome	genome	NOUN
ajmsi-1760	104	52	editing	editing	NOUN
ajmsi-1760	104	53	in	in	ADP
ajmsi-1760	104	54	human	human	ADJ
ajmsi-1760	104	55	hematopoietic	hematopoietic	ADJ
ajmsi-1760	104	56	stem	stem	NOUN
ajmsi-1760	104	57	cells	cell	NOUN
ajmsi-1760	104	58	(	(	PUNCT
ajmsi-1760	104	59	hscs	hsc	NOUN
ajmsi-1760	104	60	)	)	PUNCT
ajmsi-1760	104	61	(	(	PUNCT
ajmsi-1760	104	62	bak	bak	NOUN
ajmsi-1760	104	63	,	,	PUNCT
ajmsi-1760	104	64	2018	2018	NUM
ajmsi-1760	104	65	)	)	PUNCT
ajmsi-1760	104	66	genomic	genomic	NOUN
ajmsi-1760	104	67	editing	editing	NOUN
ajmsi-1760	104	68	via	via	ADP
ajmsi-1760	104	69	homologous	homologous	ADJ
ajmsi-1760	104	70	recombination	recombination	NOUN
ajmsi-1760	104	71	(	(	PUNCT
ajmsi-1760	104	72	hr	hr	NOUN
ajmsi-1760	104	73	)	)	PUNCT
ajmsi-1760	104	74	in	in	ADP
ajmsi-1760	104	75	human	human	ADJ
ajmsi-1760	104	76	hscs	hsc	NOUN
ajmsi-1760	104	77	has	have	VERB
ajmsi-1760	104	78	the	the	DET
ajmsi-1760	104	79	power	power	NOUN
ajmsi-1760	104	80	to	to	PART
ajmsi-1760	104	81	reveal	reveal	VERB
ajmsi-1760	104	82	gene	gene	NOUN
ajmsi-1760	104	83	-	-	PUNCT
ajmsi-1760	104	84	function	function	NOUN
ajmsi-1760	104	85	relationships	relationship	NOUN
ajmsi-1760	104	86	and	and	CCONJ
ajmsi-1760	104	87	potentially	potentially	ADV
ajmsi-1760	104	88	transform	transform	VERB
ajmsi-1760	104	89	curative	curative	ADJ
ajmsi-1760	104	90	hematological	hematological	ADJ
ajmsi-1760	104	91	gene	gene	NOUN
ajmsi-1760	104	92	and	and	CCONJ
ajmsi-1760	104	93	cell	cell	NOUN
ajmsi-1760	104	94	therapies	therapy	NOUN
ajmsi-1760	104	95	.	.	PUNCT
ajmsi-1760	105	1	e	e	NOUN
ajmsi-1760	105	2	xperim	xperim	VERB
ajmsi-1760	105	3	ental	ental	ADJ
ajmsi-1760	106	1	•	•	NUM
ajmsi-1760	106	2	production	production	NOUN
ajmsi-1760	106	3	of	of	ADP
ajmsi-1760	106	4	hr	hr	NOUN
ajmsi-1760	106	5	targeted	target	VERB
ajmsi-1760	106	6	hscs	hsc	NOUN
ajmsi-1760	106	7	•	•	NUM
ajmsi-1760	106	8	enrichment	enrichment	NOUN
ajmsi-1760	106	9	of	of	ADP
ajmsi-1760	106	10	hr	hr	NOUN
ajmsi-1760	106	11	targeted	target	VERB
ajmsi-1760	106	12	hscs	hsc	NOUN
ajmsi-1760	106	13	•	•	NOUN
ajmsi-1760	106	14	in	in	ADP
ajmsi-1760	106	15	vitro	vitro	X
ajmsi-1760	106	16	analysis	analysis	NOUN
ajmsi-1760	106	17	of	of	ADP
ajmsi-1760	106	18	hr	hr	NOUN
ajmsi-1760	106	19	targeted	target	VERB
ajmsi-1760	106	20	hscs	hsc	NOUN
ajmsi-1760	106	21	•	•	NOUN
ajmsi-1760	106	22	in	in	ADP
ajmsi-1760	106	23	vivo	vivo	ADJ
ajmsi-1760	106	24	analysis	analysis	NOUN
ajmsi-1760	106	25	of	of	ADP
ajmsi-1760	106	26	hr	hr	NOUN
ajmsi-1760	106	27	targeted	target	VERB
ajmsi-1760	106	28	hscs	hsc	NOUN
ajmsi-1760	106	29	•	•	NUM
ajmsi-1760	106	30	manipulation	manipulation	NOUN
ajmsi-1760	106	31	of	of	ADP
ajmsi-1760	106	32	genes	gene	NOUN
ajmsi-1760	106	33	for	for	ADP
ajmsi-1760	106	34	investigation	investigation	NOUN
ajmsi-1760	106	35	of	of	ADP
ajmsi-1760	106	36	gene	gene	NOUN
ajmsi-1760	106	37	functions	function	NOUN
ajmsi-1760	106	38	during	during	ADP
ajmsi-1760	106	39	hematopoiesis	hematopoiesis	NOUN
ajmsi-1760	106	40	•	•	NUM
ajmsi-1760	106	41	correction	correction	NOUN
ajmsi-1760	106	42	of	of	ADP
ajmsi-1760	106	43	genetic	genetic	ADJ
ajmsi-1760	106	44	mutations	mutation	NOUN
ajmsi-1760	106	45	in	in	ADP
ajmsi-1760	106	46	hsc	hsc	PROPN
ajmsi-1760	106	47	transplantation	transplantation	NOUN
ajmsi-1760	106	48	-	-	PUNCT
ajmsi-1760	106	49	based	base	VERB
ajmsi-1760	106	50	therapies	therapy	NOUN
ajmsi-1760	106	51	for	for	ADP
ajmsi-1760	106	52	diseases	disease	NOUN
ajmsi-1760	106	53	such	such	ADJ
ajmsi-1760	106	54	as	as	ADP
ajmsi-1760	106	55	scd	scd	PROPN
ajmsi-1760	106	56	,	,	PUNCT
ajmsi-1760	106	57	β	β	NOUN
ajmsi-1760	106	58	-	-	NOUN
ajmsi-1760	106	59	thalassemia	thalassemia	NOUN
ajmsi-1760	106	60	,	,	PUNCT
ajmsi-1760	106	61	and	and	CCONJ
ajmsi-1760	106	62	primary	primary	ADJ
ajmsi-1760	106	63	immunodeficiencies	immunodeficiency	NOUN
ajmsi-1760	106	64	13	13	NUM
ajmsi-1760	106	65	efficacy	efficacy	NOUN
ajmsi-1760	106	66	of	of	ADP
ajmsi-1760	106	67	crisprbased	crisprbase	VERB
ajmsi-1760	106	68	gene	gene	NOUN
ajmsi-1760	106	69	editing	edit	VERB
ajmsi-1760	106	70	in	in	ADP
ajmsi-1760	106	71	a	a	DET
ajmsi-1760	106	72	sickle	sickle	NOUN
ajmsi-1760	106	73	cell	cell	NOUN
ajmsi-1760	106	74	disease	disease	NOUN
ajmsi-1760	106	75	patient	patient	ADJ
ajmsi-1760	106	76	as	as	SCONJ
ajmsi-1760	106	77	measured	measure	VERB
ajmsi-1760	106	78	through	through	ADP
ajmsi-1760	106	79	the	the	DET
ajmsi-1760	106	80	eye	eye	NOUN
ajmsi-1760	106	81	(	(	PUNCT
ajmsi-1760	106	82	pinhas	pinha	NOUN
ajmsi-1760	106	83	,	,	PUNCT
ajmsi-1760	106	84	2022	2022	NUM
ajmsi-1760	106	85	)	)	PUNCT
ajmsi-1760	106	86	optical	optical	ADJ
ajmsi-1760	106	87	coherence	coherence	NOUN
ajmsi-1760	106	88	tomography	tomography	NOUN
ajmsi-1760	106	89	angiography	angiography	NOUN
ajmsi-1760	106	90	can	can	AUX
ajmsi-1760	106	91	detect	detect	VERB
ajmsi-1760	106	92	and	and	CCONJ
ajmsi-1760	106	93	measure	measure	NOUN
ajmsi-1760	106	94	micro	micro	ADJ
ajmsi-1760	106	95	-	-	ADJ
ajmsi-1760	106	96	occlusive	occlusive	ADJ
ajmsi-1760	106	97	events	event	NOUN
ajmsi-1760	106	98	within	within	ADP
ajmsi-1760	106	99	the	the	DET
ajmsi-1760	106	100	retinal	retinal	ADJ
ajmsi-1760	106	101	capillary	capillary	ADJ
ajmsi-1760	106	102	bed	bed	NOUN
ajmsi-1760	106	103	before	before	ADP
ajmsi-1760	106	104	and	and	CCONJ
ajmsi-1760	106	105	after	after	ADP
ajmsi-1760	106	106	rbc	rbc	PROPN
ajmsi-1760	106	107	exchange	exchange	PROPN
ajmsi-1760	106	108	transfusion	transfusion	NOUN
ajmsi-1760	106	109	and	and	CCONJ
ajmsi-1760	106	110	following	follow	VERB
ajmsi-1760	106	111	crispr	crispr	NOUN
ajmsi-1760	106	112	-	-	PUNCT
ajmsi-1760	106	113	based	base	VERB
ajmsi-1760	106	114	gene	gene	NOUN
ajmsi-1760	106	115	editing	editing	NOUN
ajmsi-1760	106	116	.	.	PUNCT
ajmsi-1760	107	1	case	case	NOUN
ajmsi-1760	107	2	report	report	VERB
ajmsi-1760	107	3	•	•	ADP
ajmsi-1760	107	4	micro	micro	VERB
ajmsi-1760	107	5	occlusive	occlusive	ADJ
ajmsi-1760	107	6	events	event	NOUN
ajmsi-1760	107	7	within	within	ADP
ajmsi-1760	107	8	the	the	DET
ajmsi-1760	107	9	retinal	retinal	ADJ
ajmsi-1760	107	10	capillary	capillary	ADJ
ajmsi-1760	107	11	bed	bed	NOUN
ajmsi-1760	107	12	pa	pa	PROPN
ajmsi-1760	107	13	ge	ge	PROPN
ajmsi-1760	107	14	49	49	NUM
ajmsi-1760	107	15	https://journals.e-palli.com/home/index.php/ajmsi	https://journals.e-palli.com/home/index.php/ajmsi	PROPN
ajmsi-1760	107	16	am	be	AUX
ajmsi-1760	107	17	.	.	PUNCT
ajmsi-1760	108	1	j.	j.	PROPN
ajmsi-1760	108	2	med	med	PROPN
ajmsi-1760	108	3	.	.	PUNCT
ajmsi-1760	109	1	sci	sci	PROPN
ajmsi-1760	109	2	.	.	PUNCT
ajmsi-1760	109	3	innov	innov	PROPN
ajmsi-1760	109	4	.	.	PUNCT
ajmsi-1760	110	1	2(2	2(2	NUM
ajmsi-1760	110	2	)	)	PUNCT
ajmsi-1760	110	3	44	44	NUM
ajmsi-1760	110	4	-	-	SYM
ajmsi-1760	110	5	56	56	NUM
ajmsi-1760	110	6	,	,	PUNCT
ajmsi-1760	110	7	2023	2023	NUM
ajmsi-1760	110	8	14	14	NUM
ajmsi-1760	110	9	current	current	ADJ
ajmsi-1760	110	10	sickle	sickle	NOUN
ajmsi-1760	110	11	cell	cell	NOUN
ajmsi-1760	110	12	disease	disease	NOUN
ajmsi-1760	110	13	gene	gene	NOUN
ajmsi-1760	110	14	therapy	therapy	NOUN
ajmsi-1760	110	15	treatments	treatment	NOUN
ajmsi-1760	110	16	:	:	PUNCT
ajmsi-1760	110	17	literature	literature	PROPN
ajmsi-1760	110	18	review	review	PROPN
ajmsi-1760	110	19	(	(	PUNCT
ajmsi-1760	110	20	ranadive	ranadive	ADJ
ajmsi-1760	110	21	,	,	PUNCT
ajmsi-1760	110	22	2022	2022	NUM
ajmsi-1760	110	23	)	)	PUNCT
ajmsi-1760	110	24	the	the	DET
ajmsi-1760	110	25	base	base	NOUN
ajmsi-1760	110	26	editor	editor	NOUN
ajmsi-1760	110	27	shows	show	VERB
ajmsi-1760	110	28	promise	promise	NOUN
ajmsi-1760	110	29	in	in	ADP
ajmsi-1760	110	30	its	its	PRON
ajmsi-1760	110	31	ability	ability	NOUN
ajmsi-1760	110	32	to	to	PART
ajmsi-1760	110	33	surpass	surpass	VERB
ajmsi-1760	110	34	many	many	ADJ
ajmsi-1760	110	35	issues	issue	NOUN
ajmsi-1760	110	36	faced	face	VERB
ajmsi-1760	110	37	with	with	ADP
ajmsi-1760	110	38	both	both	DET
ajmsi-1760	110	39	viral	viral	ADJ
ajmsi-1760	110	40	vectors	vector	NOUN
ajmsi-1760	110	41	and	and	CCONJ
ajmsi-1760	110	42	crispr	crispr	NOUN
ajmsi-1760	110	43	-	-	PUNCT
ajmsi-1760	110	44	cas9	cas9	NOUN
ajmsi-1760	110	45	in	in	ADP
ajmsi-1760	110	46	human	human	ADJ
ajmsi-1760	110	47	trials	trial	NOUN
ajmsi-1760	110	48	.	.	PUNCT
ajmsi-1760	111	1	literature	literature	NOUN
ajmsi-1760	111	2	review	review	PROPN
ajmsi-1760	111	3	•	•	NUM
ajmsi-1760	111	4	success	success	NOUN
ajmsi-1760	111	5	of	of	ADP
ajmsi-1760	111	6	lentiviral	lentiviral	ADJ
ajmsi-1760	111	7	vectors	vector	NOUN
ajmsi-1760	111	8	in	in	ADP
ajmsi-1760	111	9	genotype	genotype	NOUN
ajmsi-1760	111	10	correction	correction	NOUN
ajmsi-1760	111	11	and	and	CCONJ
ajmsi-1760	111	12	hbf	hbf	PROPN
ajmsi-1760	111	13	induction	induction	NOUN
ajmsi-1760	111	14	•	•	NOUN
ajmsi-1760	111	15	success	success	NOUN
ajmsi-1760	111	16	of	of	ADP
ajmsi-1760	111	17	crispr	crispr	NOUN
ajmsi-1760	111	18	-	-	PUNCT
ajmsi-1760	111	19	cas9	cas9	NOUN
ajmsi-1760	111	20	in	in	ADP
ajmsi-1760	111	21	genotype	genotype	NOUN
ajmsi-1760	111	22	correction	correction	NOUN
ajmsi-1760	111	23	and	and	CCONJ
ajmsi-1760	111	24	hbf	hbf	PROPN
ajmsi-1760	111	25	induction	induction	NOUN
ajmsi-1760	112	1	•	•	NOUN
ajmsi-1760	112	2	success	success	NOUN
ajmsi-1760	112	3	of	of	ADP
ajmsi-1760	112	4	base	base	NOUN
ajmsi-1760	112	5	editors	editor	NOUN
ajmsi-1760	112	6	in	in	ADP
ajmsi-1760	112	7	genotype	genotype	NOUN
ajmsi-1760	112	8	correction	correction	NOUN
ajmsi-1760	112	9	and	and	CCONJ
ajmsi-1760	112	10	hbf	hbf	PROPN
ajmsi-1760	112	11	induction	induction	NOUN
ajmsi-1760	112	12	15	15	NUM
ajmsi-1760	112	13	crispr	crispr	ADJ
ajmsi-1760	112	14	-	-	PUNCT
ajmsi-1760	112	15	cas9	cas9	NOUN
ajmsi-1760	112	16	editing	editing	NOUN
ajmsi-1760	112	17	induces	induce	VERB
ajmsi-1760	112	18	high	high	ADJ
ajmsi-1760	112	19	rates	rate	NOUN
ajmsi-1760	112	20	of	of	ADP
ajmsi-1760	112	21	unintended	unintended	ADJ
ajmsi-1760	112	22	large	large	ADJ
ajmsi-1760	112	23	gene	gene	NOUN
ajmsi-1760	112	24	modifications	modification	NOUN
ajmsi-1760	112	25	in	in	ADP
ajmsi-1760	112	26	hspcs	hspc	NOUN
ajmsi-1760	112	27	from	from	ADP
ajmsi-1760	112	28	patients	patient	NOUN
ajmsi-1760	112	29	with	with	ADP
ajmsi-1760	112	30	sickle	sickle	NOUN
ajmsi-1760	112	31	cell	cell	NOUN
ajmsi-1760	112	32	disease	disease	NOUN
ajmsi-1760	112	33	(	(	PUNCT
ajmsi-1760	112	34	park	park	NOUN
ajmsi-1760	112	35	,	,	PUNCT
ajmsi-1760	112	36	2021b	2021b	NUM
ajmsi-1760	112	37	)	)	PUNCT
ajmsi-1760	112	38	unintended	unintended	ADJ
ajmsi-1760	112	39	on	on	ADP
ajmsi-1760	112	40	-	-	PUNCT
ajmsi-1760	112	41	target	target	VERB
ajmsi-1760	112	42	large	large	ADJ
ajmsi-1760	112	43	deletions	deletion	NOUN
ajmsi-1760	112	44	occur	occur	VERB
ajmsi-1760	112	45	at	at	ADP
ajmsi-1760	112	46	high	high	ADJ
ajmsi-1760	112	47	rates	rate	NOUN
ajmsi-1760	112	48	in	in	ADP
ajmsi-1760	112	49	gene	gene	NOUN
ajmsi-1760	112	50	-	-	PUNCT
ajmsi-1760	112	51	edited	edit	VERB
ajmsi-1760	112	52	scd	scd	NOUN
ajmsi-1760	112	53	hspcs	hspc	NOUN
ajmsi-1760	112	54	.	.	PUNCT
ajmsi-1760	113	1	e	e	AUX
ajmsi-1760	113	2	xperim	xperim	VERB
ajmsi-1760	113	3	ental	ental	ADJ
ajmsi-1760	113	4	•	•	NUM
ajmsi-1760	113	5	unintended	unintended	ADJ
ajmsi-1760	113	6	gene	gene	NOUN
ajmsi-1760	113	7	modifications	modification	NOUN
ajmsi-1760	113	8	due	due	ADJ
ajmsi-1760	113	9	to	to	ADP
ajmsi-1760	113	10	cas9	cas9	NOUN
ajmsi-1760	113	11	induced	induce	VERB
ajmsi-1760	113	12	double	double	ADJ
ajmsi-1760	113	13	stranded	strand	VERB
ajmsi-1760	113	14	breaks	break	NOUN
ajmsi-1760	113	15	(	(	PUNCT
ajmsi-1760	113	16	dsbs	dsbs	ADJ
ajmsi-1760	113	17	)	)	PUNCT
ajmsi-1760	113	18	in	in	ADP
ajmsi-1760	113	19	scd	scd	PROPN
ajmsi-1760	113	20	hspcs	hspc	NOUN
ajmsi-1760	113	21	,	,	PUNCT
ajmsi-1760	113	22	including	include	VERB
ajmsi-1760	113	23	large	large	ADJ
ajmsi-1760	113	24	deletions	deletion	NOUN
ajmsi-1760	113	25	,	,	PUNCT
ajmsi-1760	113	26	insertions	insertion	NOUN
ajmsi-1760	113	27	,	,	PUNCT
ajmsi-1760	113	28	and	and	CCONJ
ajmsi-1760	113	29	complex	complex	ADJ
ajmsi-1760	113	30	chromosomal	chromosomal	ADJ
ajmsi-1760	113	31	arrangements	arrangement	NOUN
ajmsi-1760	113	32	16	16	NUM
ajmsi-1760	113	33	automated	automate	VERB
ajmsi-1760	113	34	good	good	ADJ
ajmsi-1760	113	35	manufacturing	manufacturing	NOUN
ajmsi-1760	113	36	practicecompatible	practicecompatible	ADJ
ajmsi-1760	113	37	crisprcas9	crisprcas9	NOUN
ajmsi-1760	113	38	editing	editing	NOUN
ajmsi-1760	113	39	of	of	ADP
ajmsi-1760	113	40	hematopoietic	hematopoietic	ADJ
ajmsi-1760	113	41	stem	stem	NOUN
ajmsi-1760	113	42	and	and	CCONJ
ajmsi-1760	113	43	progenitor	progenitor	NOUN
ajmsi-1760	113	44	cells	cell	NOUN
ajmsi-1760	113	45	for	for	ADP
ajmsi-1760	113	46	clinical	clinical	ADJ
ajmsi-1760	113	47	treatment	treatment	NOUN
ajmsi-1760	113	48	of	of	ADP
ajmsi-1760	113	49	β	β	NOUN
ajmsi-1760	113	50	-	-	NOUN
ajmsi-1760	113	51	hemoglobinopathies	hemoglobinopathy	NOUN
ajmsi-1760	113	52	(	(	PUNCT
ajmsi-1760	113	53	urena	urena	NOUN
ajmsi-1760	113	54	-	-	PUNCT
ajmsi-1760	113	55	bailen	bailen	VERB
ajmsi-1760	113	56	,	,	PUNCT
ajmsi-1760	113	57	2023	2023	NUM
ajmsi-1760	113	58	)	)	PUNCT
ajmsi-1760	113	59	the	the	DET
ajmsi-1760	113	60	enhancer	enhancer	NOUN
ajmsi-1760	113	61	of	of	ADP
ajmsi-1760	113	62	the	the	DET
ajmsi-1760	113	63	bcl11a	bcl11a	NOUN
ajmsi-1760	113	64	gene	gene	NOUN
ajmsi-1760	113	65	is	be	AUX
ajmsi-1760	113	66	a	a	DET
ajmsi-1760	113	67	crispr	crispr	ADJ
ajmsi-1760	113	68	target	target	NOUN
ajmsi-1760	113	69	in	in	ADP
ajmsi-1760	113	70	ongoing	ongoing	ADJ
ajmsi-1760	113	71	clinical	clinical	ADJ
ajmsi-1760	113	72	trials	trial	NOUN
ajmsi-1760	113	73	for	for	ADP
ajmsi-1760	113	74	β	β	NOUN
ajmsi-1760	113	75	-	-	NOUN
ajmsi-1760	113	76	thalassemia	thalassemia	NOUN
ajmsi-1760	113	77	and	and	CCONJ
ajmsi-1760	113	78	scd	scd	NOUN
ajmsi-1760	113	79	treatment	treatment	NOUN
ajmsi-1760	113	80	.	.	PUNCT
ajmsi-1760	114	1	e	e	NOUN
ajmsi-1760	114	2	xperim	xperim	VERB
ajmsi-1760	114	3	ental	ental	ADJ
ajmsi-1760	114	4	•	•	NOUN
ajmsi-1760	114	5	editing	edit	VERB
ajmsi-1760	114	6	efficiency	efficiency	NOUN
ajmsi-1760	114	7	•	•	ADP
ajmsi-1760	114	8	hbf	hbf	PROPN
ajmsi-1760	114	9	resurgence	resurgence	NOUN
ajmsi-1760	114	10	17	17	NUM
ajmsi-1760	114	11	in	in	ADP
ajmsi-1760	114	12	vivo	vivo	ADJ
ajmsi-1760	114	13	selection	selection	NOUN
ajmsi-1760	114	14	for	for	ADP
ajmsi-1760	114	15	corrected	correct	VERB
ajmsi-1760	114	16	β	β	NOUN
ajmsi-1760	114	17	-	-	ADJ
ajmsi-1760	114	18	globin	globin	ADJ
ajmsi-1760	114	19	alleles	allele	NOUN
ajmsi-1760	114	20	after	after	ADP
ajmsi-1760	114	21	crisprcas9	crisprcas9	NOUN
ajmsi-1760	114	22	editing	edit	VERB
ajmsi-1760	114	23	in	in	ADP
ajmsi-1760	114	24	human	human	ADJ
ajmsi-1760	114	25	sickle	sickle	NOUN
ajmsi-1760	114	26	hematopoietic	hematopoietic	ADJ
ajmsi-1760	114	27	stem	stem	NOUN
ajmsi-1760	114	28	cells	cell	NOUN
ajmsi-1760	114	29	(	(	PUNCT
ajmsi-1760	114	30	hscs	hsc	NOUN
ajmsi-1760	114	31	)	)	PUNCT
ajmsi-1760	114	32	enhances	enhance	VERB
ajmsi-1760	114	33	therapeutic	therapeutic	ADJ
ajmsi-1760	114	34	potential	potential	NOUN
ajmsi-1760	114	35	(	(	PUNCT
ajmsi-1760	114	36	magis	magis	NOUN
ajmsi-1760	114	37	,	,	PUNCT
ajmsi-1760	114	38	2018	2018	NUM
ajmsi-1760	114	39	)	)	PUNCT
ajmsi-1760	114	40	cas9	cas9	NOUN
ajmsi-1760	114	41	-	-	PUNCT
ajmsi-1760	114	42	mediated	mediate	VERB
ajmsi-1760	114	43	gene	gene	NOUN
ajmsi-1760	114	44	editing	edit	VERB
ajmsi-1760	114	45	in	in	ADP
ajmsi-1760	114	46	long	long	ADJ
ajmsi-1760	114	47	-	-	PUNCT
ajmsi-1760	114	48	term	term	NOUN
ajmsi-1760	114	49	engrafting	engraft	VERB
ajmsi-1760	114	50	human	human	ADJ
ajmsi-1760	114	51	hscs	hsc	NOUN
ajmsi-1760	114	52	yields	yield	NOUN
ajmsi-1760	114	53	more	more	ADJ
ajmsi-1760	114	54	than	than	ADP
ajmsi-1760	114	55	20	20	NUM
ajmsi-1760	114	56	%	%	NOUN
ajmsi-1760	114	57	correction	correction	NOUN
ajmsi-1760	114	58	of	of	ADP
ajmsi-1760	114	59	the	the	DET
ajmsi-1760	114	60	sickle	sickle	NOUN
ajmsi-1760	114	61	mutation	mutation	NOUN
ajmsi-1760	114	62	in	in	ADP
ajmsi-1760	114	63	long	long	ADJ
ajmsi-1760	114	64	-	-	PUNCT
ajmsi-1760	114	65	term	term	NOUN
ajmsi-1760	114	66	engrafting	engraft	VERB
ajmsi-1760	114	67	human	human	ADJ
ajmsi-1760	114	68	hscs	hsc	NOUN
ajmsi-1760	114	69	.	.	PUNCT
ajmsi-1760	115	1	e	e	NOUN
ajmsi-1760	115	2	xperim	xperim	VERB
ajmsi-1760	115	3	ental	ental	ADJ
ajmsi-1760	115	4	•	•	NUM
ajmsi-1760	115	5	percentage	percentage	NOUN
ajmsi-1760	115	6	of	of	ADP
ajmsi-1760	115	7	correction	correction	NOUN
ajmsi-1760	115	8	of	of	ADP
ajmsi-1760	115	9	the	the	DET
ajmsi-1760	115	10	sickle	sickle	NOUN
ajmsi-1760	115	11	mutation	mutation	NOUN
ajmsi-1760	115	12	in	in	ADP
ajmsi-1760	115	13	long	long	ADJ
ajmsi-1760	115	14	term	term	NOUN
ajmsi-1760	115	15	engrafting	engraft	VERB
ajmsi-1760	115	16	human	human	ADJ
ajmsi-1760	115	17	hscs	hsc	NOUN
ajmsi-1760	115	18	•	•	NUM
ajmsi-1760	115	19	rna	rna	NOUN
ajmsi-1760	115	20	sequence	sequence	NOUN
ajmsi-1760	115	21	data	datum	NOUN
ajmsi-1760	115	22	to	to	PART
ajmsi-1760	115	23	find	find	VERB
ajmsi-1760	115	24	cells	cell	NOUN
ajmsi-1760	115	25	carrying	carry	VERB
ajmsi-1760	115	26	corrected	correct	VERB
ajmsi-1760	115	27	ss	ss	PRON
ajmsi-1760	115	28	globin	globin	NOUN
ajmsi-1760	115	29	alleles	allele	NOUN
ajmsi-1760	115	30	•	•	NOUN
ajmsi-1760	115	31	efficiency	efficiency	NOUN
ajmsi-1760	115	32	of	of	ADP
ajmsi-1760	115	33	editing	edit	VERB
ajmsi-1760	115	34	with	with	ADP
ajmsi-1760	115	35	almost	almost	ADV
ajmsi-1760	115	36	no	no	PRON
ajmsi-1760	115	37	off	off	ADJ
ajmsi-1760	115	38	target	target	NOUN
ajmsi-1760	115	39	events	event	NOUN
ajmsi-1760	115	40	18	18	NUM
ajmsi-1760	115	41	multiplex	multiplex	NOUN
ajmsi-1760	115	42	crisprcas9	crisprcas9	NOUN
ajmsi-1760	115	43	genomic	genomic	NOUN
ajmsi-1760	115	44	editing	editing	NOUN
ajmsi-1760	115	45	in	in	ADP
ajmsi-1760	115	46	hematopoietic	hematopoietic	ADJ
ajmsi-1760	115	47	stem	stem	NOUN
ajmsi-1760	115	48	cells	cell	NOUN
ajmsi-1760	115	49	for	for	ADP
ajmsi-1760	115	50	fetal	fetal	ADJ
ajmsi-1760	115	51	hemoglobin	hemoglobin	NOUN
ajmsi-1760	115	52	reinduction	reinduction	NOUN
ajmsi-1760	115	53	generates	generate	VERB
ajmsi-1760	115	54	chromosomal	chromosomal	ADJ
ajmsi-1760	115	55	translocations	translocation	NOUN
ajmsi-1760	115	56	(	(	PUNCT
ajmsi-1760	115	57	samuelson	samuelson	NOUN
ajmsi-1760	115	58	,	,	PUNCT
ajmsi-1760	115	59	2021	2021	NUM
ajmsi-1760	115	60	)	)	PUNCT
ajmsi-1760	115	61	genomic	genomic	NOUN
ajmsi-1760	115	62	editing	edit	VERB
ajmsi-1760	115	63	therapies	therapy	NOUN
ajmsi-1760	115	64	targeting	target	VERB
ajmsi-1760	115	65	either	either	CCONJ
ajmsi-1760	115	66	the	the	DET
ajmsi-1760	115	67	bcl11a	bcl11a	X
ajmsi-1760	115	68	erythroid	erythroid	ADJ
ajmsi-1760	115	69	enhancer	enhancer	NOUN
ajmsi-1760	115	70	or	or	CCONJ
ajmsi-1760	115	71	the	the	DET
ajmsi-1760	115	72	hbg	hbg	PROPN
ajmsi-1760	115	73	promoter	promoter	NOUN
ajmsi-1760	115	74	are	be	AUX
ajmsi-1760	115	75	already	already	ADV
ajmsi-1760	115	76	proving	prove	VERB
ajmsi-1760	115	77	successful	successful	ADJ
ajmsi-1760	115	78	in	in	ADP
ajmsi-1760	115	79	reinducing	reinduce	VERB
ajmsi-1760	115	80	hbf	hbf	PROPN
ajmsi-1760	115	81	.	.	PUNCT
ajmsi-1760	116	1	e	e	PROPN
ajmsi-1760	116	2	xperim	xperim	VERB
ajmsi-1760	116	3	ental	ental	ADJ
ajmsi-1760	116	4	•	•	NUM
ajmsi-1760	116	5	hbf	hbf	PROPN
ajmsi-1760	116	6	reinduction	reinduction	PROPN
ajmsi-1760	116	7	•	•	NOUN
ajmsi-1760	116	8	engraftment	engraftment	VERB
ajmsi-1760	116	9	•	•	NOUN
ajmsi-1760	116	10	lineage	lineage	NOUN
ajmsi-1760	116	11	differentiation	differentiation	NOUN
ajmsi-1760	116	12	potential	potential	NOUN
ajmsi-1760	116	13	of	of	ADP
ajmsi-1760	116	14	edited	edited	ADJ
ajmsi-1760	116	15	cells	cell	NOUN
ajmsi-1760	116	16	post	post	VERB
ajmsi-1760	116	17	xenotransplantation	xenotransplantation	NOUN
ajmsi-1760	116	18	•	•	ADP
ajmsi-1760	116	19	chromosomal	chromosomal	ADJ
ajmsi-1760	116	20	rearrangement	rearrangement	ADJ
ajmsi-1760	116	21	events	event	NOUN
ajmsi-1760	116	22	19	19	NUM
ajmsi-1760	116	23	crispr	crispr	ADJ
ajmsi-1760	116	24	-	-	PUNCT
ajmsi-1760	116	25	cas9	cas9	NOUN
ajmsi-1760	116	26	:	:	PUNCT
ajmsi-1760	116	27	a	a	DET
ajmsi-1760	116	28	preclinical	preclinical	ADJ
ajmsi-1760	116	29	and	and	CCONJ
ajmsi-1760	116	30	clinical	clinical	ADJ
ajmsi-1760	116	31	perspective	perspective	NOUN
ajmsi-1760	116	32	for	for	ADP
ajmsi-1760	116	33	the	the	DET
ajmsi-1760	116	34	treatment	treatment	NOUN
ajmsi-1760	116	35	of	of	ADP
ajmsi-1760	116	36	human	human	ADJ
ajmsi-1760	116	37	diseases	disease	NOUN
ajmsi-1760	116	38	(	(	PUNCT
ajmsi-1760	116	39	sharma	sharma	PROPN
ajmsi-1760	116	40	,	,	PUNCT
ajmsi-1760	116	41	2021	2021	NUM
ajmsi-1760	116	42	)	)	PUNCT
ajmsi-1760	116	43	crispr	crispr	NOUN
ajmsi-1760	116	44	-	-	PUNCT
ajmsi-1760	116	45	cas9	cas9	NOUN
ajmsi-1760	116	46	is	be	AUX
ajmsi-1760	116	47	a	a	DET
ajmsi-1760	116	48	promising	promising	ADJ
ajmsi-1760	116	49	genome	genome	NOUN
ajmsi-1760	116	50	-	-	PUNCT
ajmsi-1760	116	51	editing	edit	VERB
ajmsi-1760	116	52	tool	tool	NOUN
ajmsi-1760	116	53	that	that	PRON
ajmsi-1760	116	54	has	have	VERB
ajmsi-1760	116	55	therapeutic	therapeutic	ADJ
ajmsi-1760	116	56	potential	potential	NOUN
ajmsi-1760	116	57	against	against	ADP
ajmsi-1760	116	58	incurable	incurable	ADJ
ajmsi-1760	116	59	genetic	genetic	ADJ
ajmsi-1760	116	60	disorders	disorder	NOUN
ajmsi-1760	116	61	by	by	ADP
ajmsi-1760	116	62	modifying	modify	VERB
ajmsi-1760	116	63	their	their	PRON
ajmsi-1760	116	64	dna	dna	NOUN
ajmsi-1760	116	65	sequences	sequence	NOUN
ajmsi-1760	116	66	.	.	PUNCT
ajmsi-1760	117	1	e	e	NOUN
ajmsi-1760	117	2	xperim	xperim	VERB
ajmsi-1760	117	3	ental	ental	ADJ
ajmsi-1760	117	4	•	•	NUM
ajmsi-1760	117	5	modulation	modulation	NOUN
ajmsi-1760	117	6	of	of	ADP
ajmsi-1760	117	7	predefined	predefine	VERB
ajmsi-1760	117	8	gene	gene	NOUN
ajmsi-1760	117	9	expression	expression	NOUN
ajmsi-1760	117	10	(	(	PUNCT
ajmsi-1760	117	11	upregulation	upregulation	NOUN
ajmsi-1760	117	12	or	or	CCONJ
ajmsi-1760	117	13	downregulation	downregulation	NOUN
ajmsi-1760	117	14	)	)	PUNCT
ajmsi-1760	117	15	20	20	NUM
ajmsi-1760	117	16	genomic	genomic	NOUN
ajmsi-1760	117	17	editing	editing	NOUN
ajmsi-1760	117	18	:	:	PUNCT
ajmsi-1760	117	19	a	a	DET
ajmsi-1760	117	20	perspective	perspective	NOUN
ajmsi-1760	117	21	on	on	ADP
ajmsi-1760	117	22	the	the	DET
ajmsi-1760	117	23	application	application	NOUN
ajmsi-1760	117	24	of	of	ADP
ajmsi-1760	117	25	crisprcas9	crisprcas9	NOUN
ajmsi-1760	117	26	to	to	PART
ajmsi-1760	117	27	study	study	VERB
ajmsi-1760	117	28	human	human	ADJ
ajmsi-1760	117	29	diseases	disease	NOUN
ajmsi-1760	117	30	(	(	PUNCT
ajmsi-1760	117	31	review	review	NOUN
ajmsi-1760	117	32	)	)	PUNCT
ajmsi-1760	117	33	(	(	PUNCT
ajmsi-1760	117	34	rodriguez	rodriguez	NOUN
ajmsi-1760	117	35	-	-	PUNCT
ajmsi-1760	117	36	rodriguez	rodriguez	NOUN
ajmsi-1760	117	37	,	,	PUNCT
ajmsi-1760	117	38	2019	2019	NUM
ajmsi-1760	117	39	)	)	PUNCT
ajmsi-1760	117	40	the	the	DET
ajmsi-1760	117	41	crispr	crispr	ADJ
ajmsi-1760	117	42	-	-	PUNCT
ajmsi-1760	117	43	cas9	cas9	NOUN
ajmsi-1760	117	44	system	system	NOUN
ajmsi-1760	117	45	can	can	AUX
ajmsi-1760	117	46	repair	repair	VERB
ajmsi-1760	117	47	the	the	DET
ajmsi-1760	117	48	damage	damage	NOUN
ajmsi-1760	117	49	caused	cause	VERB
ajmsi-1760	117	50	to	to	ADP
ajmsi-1760	117	51	dna	dna	PROPN
ajmsi-1760	117	52	.	.	PUNCT
ajmsi-1760	118	1	review	review	VERB
ajmsi-1760	118	2	•	•	NUM
ajmsi-1760	118	3	the	the	DET
ajmsi-1760	118	4	basic	basic	ADJ
ajmsi-1760	118	5	principles	principle	NOUN
ajmsi-1760	118	6	of	of	ADP
ajmsi-1760	118	7	the	the	DET
ajmsi-1760	118	8	crispr	crispr	ADJ
ajmsi-1760	118	9	-	-	PUNCT
ajmsi-1760	118	10	cas9	cas9	NOUN
ajmsi-1760	118	11	system	system	NOUN
ajmsi-1760	118	12	are	be	AUX
ajmsi-1760	118	13	reviewed	review	VERB
ajmsi-1760	118	14	,	,	PUNCT
ajmsi-1760	118	15	as	as	ADV
ajmsi-1760	118	16	well	well	ADV
ajmsi-1760	118	17	as	as	ADP
ajmsi-1760	118	18	the	the	DET
ajmsi-1760	118	19	strategies	strategy	NOUN
ajmsi-1760	118	20	and	and	CCONJ
ajmsi-1760	118	21	modifications	modification	NOUN
ajmsi-1760	118	22	of	of	ADP
ajmsi-1760	118	23	the	the	DET
ajmsi-1760	118	24	enzyme	enzyme	NOUN
ajmsi-1760	118	25	cas9	cas9	NOUN
ajmsi-1760	118	26	to	to	PART
ajmsi-1760	118	27	eliminate	eliminate	VERB
ajmsi-1760	118	28	the	the	DET
ajmsi-1760	118	29	off	off	ADJ
ajmsi-1760	118	30	-	-	PUNCT
ajmsi-1760	118	31	target	target	NOUN
ajmsi-1760	118	32	cuts	cut	NOUN
ajmsi-1760	118	33	,	,	PUNCT
ajmsi-1760	118	34	and	and	CCONJ
ajmsi-1760	118	35	the	the	DET
ajmsi-1760	118	36	different	different	ADJ
ajmsi-1760	118	37	applications	application	NOUN
ajmsi-1760	118	38	of	of	ADP
ajmsi-1760	118	39	crispr	crispr	NOUN
ajmsi-1760	118	40	-	-	PUNCT
ajmsi-1760	118	41	cas9	cas9	NOUN
ajmsi-1760	118	42	as	as	ADP
ajmsi-1760	118	43	a	a	DET
ajmsi-1760	118	44	system	system	NOUN
ajmsi-1760	118	45	for	for	ADP
ajmsi-1760	118	46	visualization	visualization	NOUN
ajmsi-1760	118	47	and	and	CCONJ
ajmsi-1760	118	48	gene	gene	NOUN
ajmsi-1760	118	49	expression	expression	NOUN
ajmsi-1760	118	50	activation	activation	NOUN
ajmsi-1760	118	51	or	or	CCONJ
ajmsi-1760	118	52	suppression	suppression	NOUN
ajmsi-1760	118	53	pa	pa	PROPN
ajmsi-1760	118	54	ge	ge	PROPN
ajmsi-1760	118	55	50	50	NUM
ajmsi-1760	118	56	https://journals.e-palli.com/home/index.php/ajmsi	https://journals.e-palli.com/home/index.php/ajmsi	NOUN
ajmsi-1760	118	57	am	be	AUX
ajmsi-1760	118	58	.	.	PUNCT
ajmsi-1760	119	1	j.	j.	PROPN
ajmsi-1760	119	2	med	med	PROPN
ajmsi-1760	119	3	.	.	PUNCT
ajmsi-1760	120	1	sci	sci	PROPN
ajmsi-1760	120	2	.	.	PUNCT
ajmsi-1760	120	3	innov	innov	PROPN
ajmsi-1760	120	4	.	.	PUNCT
ajmsi-1760	121	1	2(2	2(2	NUM
ajmsi-1760	121	2	)	)	PUNCT
ajmsi-1760	121	3	44	44	NUM
ajmsi-1760	121	4	-	-	SYM
ajmsi-1760	121	5	56	56	NUM
ajmsi-1760	121	6	,	,	PUNCT
ajmsi-1760	121	7	2023	2023	NUM
ajmsi-1760	121	8	21	21	NUM
ajmsi-1760	121	9	use	use	NOUN
ajmsi-1760	121	10	of	of	ADP
ajmsi-1760	121	11	genomic	genomic	NOUN
ajmsi-1760	121	12	editing	editing	NOUN
ajmsi-1760	121	13	tools	tool	NOUN
ajmsi-1760	121	14	to	to	PART
ajmsi-1760	121	15	treat	treat	VERB
ajmsi-1760	121	16	sickle	sickle	NOUN
ajmsi-1760	121	17	cell	cell	NOUN
ajmsi-1760	121	18	disease	disease	NOUN
ajmsi-1760	121	19	(	(	PUNCT
ajmsi-1760	121	20	tasan	tasan	NOUN
ajmsi-1760	121	21	,	,	PUNCT
ajmsi-1760	121	22	2016	2016	NUM
ajmsi-1760	121	23	)	)	PUNCT
ajmsi-1760	121	24	the	the	DET
ajmsi-1760	121	25	only	only	ADJ
ajmsi-1760	121	26	existing	exist	VERB
ajmsi-1760	121	27	curative	curative	ADJ
ajmsi-1760	121	28	treatment	treatment	NOUN
ajmsi-1760	121	29	for	for	ADP
ajmsi-1760	121	30	scd	scd	NOUN
ajmsi-1760	121	31	is	be	AUX
ajmsi-1760	121	32	based	base	VERB
ajmsi-1760	121	33	on	on	ADP
ajmsi-1760	121	34	allogeneic	allogeneic	ADJ
ajmsi-1760	121	35	stem	stem	NOUN
ajmsi-1760	121	36	cell	cell	NOUN
ajmsi-1760	121	37	transplantation	transplantation	NOUN
ajmsi-1760	121	38	from	from	ADP
ajmsi-1760	121	39	healthy	healthy	ADJ
ajmsi-1760	121	40	donors	donor	NOUN
ajmsi-1760	121	41	.	.	PUNCT
ajmsi-1760	122	1	e	e	NOUN
ajmsi-1760	122	2	xperim	xperim	VERB
ajmsi-1760	122	3	ental	ental	ADJ
ajmsi-1760	123	1	•	•	NUM
ajmsi-1760	123	2	discussion	discussion	NOUN
ajmsi-1760	123	3	of	of	ADP
ajmsi-1760	123	4	the	the	DET
ajmsi-1760	123	5	three	three	NUM
ajmsi-1760	123	6	programmable	programmable	ADJ
ajmsi-1760	123	7	nucleases	nuclease	NOUN
ajmsi-1760	123	8	that	that	PRON
ajmsi-1760	123	9	are	be	AUX
ajmsi-1760	123	10	commonly	commonly	ADV
ajmsi-1760	123	11	used	use	VERB
ajmsi-1760	123	12	for	for	ADP
ajmsi-1760	123	13	genomic	genomic	NOUN
ajmsi-1760	123	14	editing	editing	NOUN
ajmsi-1760	123	15	purposes	purpose	NOUN
ajmsi-1760	123	16	:	:	PUNCT
ajmsi-1760	123	17	zinc	zinc	NOUN
ajmsi-1760	123	18	finger	finger	NOUN
ajmsi-1760	123	19	nucleases	nuclease	NOUN
ajmsi-1760	123	20	(	(	PUNCT
ajmsi-1760	123	21	zfns	zfns	NOUN
ajmsi-1760	123	22	)	)	PUNCT
ajmsi-1760	123	23	,	,	PUNCT
ajmsi-1760	123	24	transcription	transcription	NOUN
ajmsi-1760	123	25	activator	activator	NOUN
ajmsi-1760	123	26	-	-	PUNCT
ajmsi-1760	123	27	like	like	ADJ
ajmsi-1760	123	28	effector	effector	NOUN
ajmsi-1760	123	29	nucleases	nuclease	NOUN
ajmsi-1760	123	30	(	(	PUNCT
ajmsi-1760	123	31	talens	talen	NOUN
ajmsi-1760	123	32	)	)	PUNCT
ajmsi-1760	123	33	and	and	CCONJ
ajmsi-1760	123	34	crispr	crispr	NOUN
ajmsi-1760	123	35	-	-	PUNCT
ajmsi-1760	123	36	cas9	cas9	NOUN
ajmsi-1760	123	37	22	22	NUM
ajmsi-1760	123	38	crispr	crispr	ADJ
ajmsi-1760	123	39	-	-	PUNCT
ajmsi-1760	123	40	cas9	cas9	NOUN
ajmsi-1760	123	41	β	β	NOUN
ajmsi-1760	123	42	-	-	ADJ
ajmsi-1760	123	43	globin	globin	ADJ
ajmsi-1760	123	44	gene	gene	NOUN
ajmsi-1760	123	45	targeting	target	VERB
ajmsi-1760	123	46	in	in	ADP
ajmsi-1760	123	47	human	human	ADJ
ajmsi-1760	123	48	hematopoietic	hematopoietic	ADJ
ajmsi-1760	123	49	stem	stem	NOUN
ajmsi-1760	123	50	cells	cell	NOUN
ajmsi-1760	123	51	(	(	PUNCT
ajmsi-1760	123	52	dever	dever	NOUN
ajmsi-1760	123	53	,	,	PUNCT
ajmsi-1760	123	54	2016	2016	NUM
ajmsi-1760	123	55	)	)	PUNCT
ajmsi-1760	123	56	ex	ex	PRON
ajmsi-1760	123	57	vivo	vivo	ADJ
ajmsi-1760	123	58	gene	gene	NOUN
ajmsi-1760	123	59	correction	correction	NOUN
ajmsi-1760	123	60	in	in	ADP
ajmsi-1760	123	61	patient	patient	NOUN
ajmsi-1760	123	62	-	-	PUNCT
ajmsi-1760	123	63	derived	derive	VERB
ajmsi-1760	123	64	hscs	hsc	NOUN
ajmsi-1760	123	65	followed	follow	VERB
ajmsi-1760	123	66	by	by	ADP
ajmsi-1760	123	67	autologous	autologous	ADJ
ajmsi-1760	123	68	transplantation	transplantation	NOUN
ajmsi-1760	123	69	could	could	AUX
ajmsi-1760	123	70	be	be	AUX
ajmsi-1760	123	71	used	use	VERB
ajmsi-1760	123	72	to	to	PART
ajmsi-1760	123	73	cure	cure	VERB
ajmsi-1760	123	74	hemoglobinopathies	hemoglobinopathy	NOUN
ajmsi-1760	123	75	.	.	PUNCT
ajmsi-1760	124	1	preclinical	preclinical	ADJ
ajmsi-1760	124	2	trial	trial	NOUN
ajmsi-1760	124	3	•	•	ADP
ajmsi-1760	124	4	homologous	homologous	ADJ
ajmsi-1760	124	5	recombination	recombination	NOUN
ajmsi-1760	124	6	at	at	ADP
ajmsi-1760	124	7	the	the	DET
ajmsi-1760	124	8	hbb	hbb	PROPN
ajmsi-1760	124	9	gene	gene	NOUN
ajmsi-1760	124	10	in	in	ADP
ajmsi-1760	124	11	hscs	hscs	ADJ
ajmsi-1760	124	12	•	•	NUM
ajmsi-1760	124	13	efficiency	efficiency	NOUN
ajmsi-1760	124	14	of	of	ADP
ajmsi-1760	124	15	correction	correction	NOUN
ajmsi-1760	124	16	of	of	ADP
ajmsi-1760	124	17	the	the	DET
ajmsi-1760	124	18	glu6val	glu6val	ADJ
ajmsi-1760	124	19	mutation	mutation	NOUN
ajmsi-1760	124	20	responsible	responsible	ADJ
ajmsi-1760	124	21	for	for	ADP
ajmsi-1760	124	22	scd	scd	NOUN
ajmsi-1760	124	23	•	•	NOUN
ajmsi-1760	124	24	expression	expression	NOUN
ajmsi-1760	124	25	of	of	ADP
ajmsi-1760	124	26	adult	adult	NOUN
ajmsi-1760	124	27	β	β	NOUN
ajmsi-1760	124	28	-	-	NOUN
ajmsi-1760	124	29	globin	globin	ADJ
ajmsi-1760	124	30	(	(	PUNCT
ajmsi-1760	124	31	hba	hba	NOUN
ajmsi-1760	124	32	)	)	PUNCT
ajmsi-1760	124	33	messenger	messenger	NOUN
ajmsi-1760	124	34	rna	rna	NOUN
ajmsi-1760	124	35	after	after	ADP
ajmsi-1760	124	36	differentiation	differentiation	NOUN
ajmsi-1760	124	37	into	into	ADP
ajmsi-1760	124	38	erythrocytes	erythrocyte	NOUN
ajmsi-1760	124	39	23	23	NUM
ajmsi-1760	124	40	a	a	DET
ajmsi-1760	124	41	systematic	systematic	ADJ
ajmsi-1760	124	42	review	review	NOUN
ajmsi-1760	124	43	of	of	ADP
ajmsi-1760	124	44	gene	gene	NOUN
ajmsi-1760	124	45	editing	edit	VERB
ajmsi-1760	124	46	clinical	clinical	ADJ
ajmsi-1760	124	47	trials	trial	NOUN
ajmsi-1760	124	48	(	(	PUNCT
ajmsi-1760	124	49	eshka	eshka	VERB
ajmsi-1760	124	50	,	,	PUNCT
ajmsi-1760	124	51	2022	2022	NUM
ajmsi-1760	124	52	)	)	PUNCT
ajmsi-1760	124	53	there	there	PRON
ajmsi-1760	124	54	are	be	VERB
ajmsi-1760	124	55	promising	promise	VERB
ajmsi-1760	124	56	phase	phase	NOUN
ajmsi-1760	124	57	-	-	PUNCT
ajmsi-1760	124	58	i	i	NOUN
ajmsi-1760	124	59	and	and	CCONJ
ajmsi-1760	124	60	phase	phase	NOUN
ajmsi-1760	124	61	-	-	PUNCT
ajmsi-1760	124	62	ii	ii	NOUN
ajmsi-1760	124	63	trials	trial	NOUN
ajmsi-1760	124	64	testing	test	VERB
ajmsi-1760	124	65	the	the	DET
ajmsi-1760	124	66	safety	safety	NOUN
ajmsi-1760	124	67	and	and	CCONJ
ajmsi-1760	124	68	feasibility	feasibility	NOUN
ajmsi-1760	124	69	of	of	ADP
ajmsi-1760	124	70	gene	gene	NOUN
ajmsi-1760	124	71	editing	edit	VERB
ajmsi-1760	124	72	in	in	ADP
ajmsi-1760	124	73	different	different	ADJ
ajmsi-1760	124	74	clinical	clinical	ADJ
ajmsi-1760	124	75	settings	setting	NOUN
ajmsi-1760	124	76	.	.	PUNCT
ajmsi-1760	125	1	literature	literature	NOUN
ajmsi-1760	125	2	review	review	PROPN
ajmsi-1760	125	3	•	•	NUM
ajmsi-1760	125	4	gene	gene	NOUN
ajmsi-1760	125	5	editing	edit	VERB
ajmsi-1760	125	6	clinical	clinical	ADJ
ajmsi-1760	125	7	trials	trial	NOUN
ajmsi-1760	125	8	•	•	ADV
ajmsi-1760	125	9	genetically	genetically	ADV
ajmsi-1760	125	10	engineered	engineer	VERB
ajmsi-1760	125	11	t	t	NOUN
ajmsi-1760	125	12	-	-	PUNCT
ajmsi-1760	125	13	cell	cell	NOUN
ajmsi-1760	125	14	therapies	therapy	NOUN
ajmsi-1760	125	15	for	for	ADP
ajmsi-1760	125	16	cancer	cancer	NOUN
ajmsi-1760	125	17	•	•	PROPN
ajmsi-1760	125	18	virus	virus	NOUN
ajmsi-1760	125	19	infections	infection	NOUN
ajmsi-1760	125	20	•	•	ADP
ajmsi-1760	125	21	monogenic	monogenic	ADJ
ajmsi-1760	125	22	diseases	disease	NOUN
ajmsi-1760	125	23	24	24	NUM
ajmsi-1760	125	24	genetic	genetic	ADJ
ajmsi-1760	125	25	treatment	treatment	NOUN
ajmsi-1760	125	26	of	of	ADP
ajmsi-1760	125	27	a	a	DET
ajmsi-1760	125	28	molecular	molecular	ADJ
ajmsi-1760	125	29	disorder	disorder	NOUN
ajmsi-1760	125	30	:	:	PUNCT
ajmsi-1760	125	31	gene	gene	NOUN
ajmsi-1760	125	32	therapy	therapy	NOUN
ajmsi-1760	125	33	approaches	approach	VERB
ajmsi-1760	125	34	to	to	ADP
ajmsi-1760	125	35	sickle	sickle	VERB
ajmsi-1760	125	36	cell	cell	NOUN
ajmsi-1760	125	37	disease	disease	NOUN
ajmsi-1760	125	38	(	(	PUNCT
ajmsi-1760	125	39	hoban	hoban	NOUN
ajmsi-1760	125	40	,	,	PUNCT
ajmsi-1760	125	41	2016b	2016b	NUM
ajmsi-1760	125	42	)	)	PUNCT
ajmsi-1760	125	43	the	the	DET
ajmsi-1760	125	44	initial	initial	ADJ
ajmsi-1760	125	45	-	-	PUNCT
ajmsi-1760	125	46	retroviral	retroviral	ADJ
ajmsi-1760	125	47	vectors	vector	NOUN
ajmsi-1760	125	48	,	,	PUNCT
ajmsi-1760	125	49	nextgeneration	nextgeneration	NOUN
ajmsi-1760	125	50	lentiviral	lentiviral	ADJ
ajmsi-1760	125	51	vectors	vector	NOUN
ajmsi-1760	125	52	,	,	PUNCT
ajmsi-1760	125	53	and	and	CCONJ
ajmsi-1760	125	54	novel	novel	ADJ
ajmsi-1760	125	55	genomic	genomic	NOUN
ajmsi-1760	125	56	engineering	engineering	NOUN
ajmsi-1760	125	57	and	and	CCONJ
ajmsi-1760	125	58	gene	gene	NOUN
ajmsi-1760	125	59	regulation	regulation	NOUN
ajmsi-1760	125	60	approaches	approach	NOUN
ajmsi-1760	125	61	share	share	VERB
ajmsi-1760	125	62	the	the	DET
ajmsi-1760	125	63	goal	goal	NOUN
ajmsi-1760	125	64	of	of	ADP
ajmsi-1760	125	65	preventing	prevent	VERB
ajmsi-1760	125	66	erythrocyte	erythrocyte	NOUN
ajmsi-1760	125	67	sickling	sickling	NOUN
ajmsi-1760	125	68	.	.	PUNCT
ajmsi-1760	126	1	review	review	VERB
ajmsi-1760	126	2	•	•	NOUN
ajmsi-1760	126	3	effective	effective	ADJ
ajmsi-1760	126	4	medical	medical	ADJ
ajmsi-1760	126	5	management	management	NOUN
ajmsi-1760	126	6	for	for	ADP
ajmsi-1760	126	7	scd	scd	NOUN
ajmsi-1760	126	8	•	•	NOUN
ajmsi-1760	126	9	preventing	prevent	VERB
ajmsi-1760	126	10	erythrocyte	erythrocyte	NOUN
ajmsi-1760	126	11	sickling	sickle	VERB
ajmsi-1760	126	12	•	•	ADJ
ajmsi-1760	126	13	clinical	clinical	ADJ
ajmsi-1760	126	14	success	success	NOUN
ajmsi-1760	126	15	25	25	NUM
ajmsi-1760	126	16	efficient	efficient	ADJ
ajmsi-1760	126	17	ablation	ablation	NOUN
ajmsi-1760	126	18	of	of	ADP
ajmsi-1760	126	19	genes	gene	NOUN
ajmsi-1760	126	20	in	in	ADP
ajmsi-1760	126	21	human	human	ADJ
ajmsi-1760	126	22	hematopoietic	hematopoietic	ADJ
ajmsi-1760	126	23	stem	stem	NOUN
ajmsi-1760	126	24	and	and	CCONJ
ajmsi-1760	126	25	effector	effector	NOUN
ajmsi-1760	126	26	cells	cell	NOUN
ajmsi-1760	126	27	using	use	VERB
ajmsi-1760	126	28	crispr	crispr	NOUN
ajmsi-1760	126	29	-	-	PUNCT
ajmsi-1760	126	30	cas9	cas9	NOUN
ajmsi-1760	126	31	(	(	PUNCT
ajmsi-1760	126	32	mandal	mandal	PROPN
ajmsi-1760	126	33	,	,	PUNCT
ajmsi-1760	126	34	2014	2014	NUM
ajmsi-1760	126	35	)	)	PUNCT
ajmsi-1760	126	36	crispr	crispr	NOUN
ajmsi-1760	126	37	-	-	PUNCT
ajmsi-1760	126	38	cas9	cas9	NOUN
ajmsi-1760	126	39	can	can	AUX
ajmsi-1760	126	40	efficiently	efficiently	ADV
ajmsi-1760	126	41	ablate	ablate	VERB
ajmsi-1760	126	42	genes	gene	NOUN
ajmsi-1760	126	43	in	in	ADP
ajmsi-1760	126	44	hspcs	hspc	NOUN
ajmsi-1760	126	45	.	.	PUNCT
ajmsi-1760	127	1	e	e	NOUN
ajmsi-1760	127	2	xperim	xperim	VERB
ajmsi-1760	127	3	ental	ental	ADJ
ajmsi-1760	127	4	•	•	ADJ
ajmsi-1760	127	5	efficacy	efficacy	NOUN
ajmsi-1760	127	6	of	of	ADP
ajmsi-1760	127	7	crispr	crispr	NOUN
ajmsi-1760	127	8	-	-	PUNCT
ajmsi-1760	127	9	cas9mediated	cas9mediate	VERB
ajmsi-1760	127	10	genomic	genomic	NOUN
ajmsi-1760	127	11	editing	editing	NOUN
ajmsi-1760	127	12	in	in	ADP
ajmsi-1760	127	13	primary	primary	ADJ
ajmsi-1760	127	14	human	human	PROPN
ajmsi-1760	127	15	cd4	cd4	PROPN
ajmsi-1760	127	16	+	+	PROPN
ajmsi-1760	127	17	t	t	NOUN
ajmsi-1760	127	18	cells	cell	NOUN
ajmsi-1760	127	19	and	and	CCONJ
ajmsi-1760	127	20	cd34	cd34	PROPN
ajmsi-1760	127	21	+	+	NUM
ajmsi-1760	127	22	hspcs	hspc	NOUN
ajmsi-1760	127	23	•	•	NOUN
ajmsi-1760	127	24	gene	gene	NOUN
ajmsi-1760	127	25	deletion	deletion	NOUN
ajmsi-1760	127	26	efficacy	efficacy	NOUN
ajmsi-1760	127	27	in	in	ADP
ajmsi-1760	127	28	cd4	cd4	PROPN
ajmsi-1760	127	29	+	+	PROPN
ajmsi-1760	127	30	t	t	NOUN
ajmsi-1760	127	31	cells	cell	NOUN
ajmsi-1760	127	32	and	and	CCONJ
ajmsi-1760	127	33	cd34	cd34	PROPN
ajmsi-1760	127	34	+	+	NUM
ajmsi-1760	127	35	hspcs	hspc	NOUN
ajmsi-1760	127	36	•	•	NOUN
ajmsi-1760	127	37	multilineage	multilineage	NOUN
ajmsi-1760	127	38	potential	potential	NOUN
ajmsi-1760	127	39	of	of	ADP
ajmsi-1760	127	40	hspcs	hspc	NOUN
ajmsi-1760	127	41	that	that	PRON
ajmsi-1760	127	42	had	have	AUX
ajmsi-1760	127	43	undergone	undergo	VERB
ajmsi-1760	127	44	genome	genome	NOUN
ajmsi-1760	127	45	editing	editing	NOUN
ajmsi-1760	127	46	with	with	ADP
ajmsi-1760	127	47	crisprcas9	crisprcas9	NOUN
ajmsi-1760	127	48	•	•	NUM
ajmsi-1760	127	49	predicted	predict	VERB
ajmsi-1760	127	50	on	on	ADP
ajmsi-1760	127	51	and	and	CCONJ
ajmsi-1760	127	52	off	off	ADP
ajmsi-1760	127	53	target	target	NOUN
ajmsi-1760	127	54	mutations	mutation	NOUN
ajmsi-1760	127	55	via	via	ADP
ajmsi-1760	127	56	target	target	NOUN
ajmsi-1760	127	57	capture	capture	NOUN
ajmsi-1760	127	58	sequencing	sequence	VERB
ajmsi-1760	127	59	in	in	ADP
ajmsi-1760	127	60	hspcs	hspc	NOUN
ajmsi-1760	127	61	•	•	NOUN
ajmsi-1760	127	62	levels	level	NOUN
ajmsi-1760	127	63	of	of	ADP
ajmsi-1760	127	64	off	off	ADP
ajmsi-1760	127	65	target	target	NOUN
ajmsi-1760	127	66	mutagen	mutagen	NOUN
ajmsi-1760	127	67	26	26	NUM
ajmsi-1760	127	68	selection	selection	NOUN
ajmsi-1760	127	69	-	-	PUNCT
ajmsi-1760	127	70	free	free	ADJ
ajmsi-1760	127	71	genomic	genomic	NOUN
ajmsi-1760	127	72	editing	editing	NOUN
ajmsi-1760	127	73	of	of	ADP
ajmsi-1760	127	74	the	the	DET
ajmsi-1760	127	75	sickle	sickle	NOUN
ajmsi-1760	127	76	mutation	mutation	NOUN
ajmsi-1760	127	77	in	in	ADP
ajmsi-1760	127	78	human	human	ADJ
ajmsi-1760	127	79	adult	adult	NOUN
ajmsi-1760	127	80	hematopoietic	hematopoietic	ADJ
ajmsi-1760	127	81	stem	stem	NOUN
ajmsi-1760	127	82	/	/	SYM
ajmsi-1760	127	83	progenitor	progenitor	NOUN
ajmsi-1760	127	84	cells	cell	NOUN
ajmsi-1760	127	85	(	(	PUNCT
ajmsi-1760	127	86	dewitt	dewitt	PROPN
ajmsi-1760	127	87	,	,	PUNCT
ajmsi-1760	127	88	2016	2016	NUM
ajmsi-1760	127	89	)	)	PUNCT
ajmsi-1760	127	90	a	a	DET
ajmsi-1760	127	91	cas9	cas9	NOUN
ajmsi-1760	127	92	rnp	rnp	PROPN
ajmsi-1760	127	93	can	can	AUX
ajmsi-1760	127	94	mediate	mediate	VERB
ajmsi-1760	127	95	efficient	efficient	ADJ
ajmsi-1760	127	96	hematopoietic	hematopoietic	ADJ
ajmsi-1760	127	97	stem	stem	NOUN
ajmsi-1760	127	98	cell	cell	NOUN
ajmsi-1760	127	99	genomic	genomic	NOUN
ajmsi-1760	127	100	editing	editing	NOUN
ajmsi-1760	127	101	in	in	ADP
ajmsi-1760	127	102	human	human	ADJ
ajmsi-1760	127	103	hematopoietic	hematopoietic	ADJ
ajmsi-1760	127	104	stem	stem	NOUN
ajmsi-1760	127	105	cells	cell	NOUN
ajmsi-1760	127	106	from	from	ADP
ajmsi-1760	127	107	sickle	sickle	NOUN
ajmsi-1760	127	108	cell	cell	NOUN
ajmsi-1760	127	109	disease	disease	NOUN
ajmsi-1760	127	110	patients	patient	NOUN
ajmsi-1760	127	111	.	.	PUNCT
ajmsi-1760	128	1	e	e	NOUN
ajmsi-1760	128	2	xperim	xperim	VERB
ajmsi-1760	128	3	ental	ental	ADJ
ajmsi-1760	129	1	•	•	NUM
ajmsi-1760	129	2	production	production	NOUN
ajmsi-1760	129	3	of	of	ADP
ajmsi-1760	129	4	normal	normal	ADJ
ajmsi-1760	129	5	hemoglobin	hemoglobin	NOUN
ajmsi-1760	129	6	•	•	NOUN
ajmsi-1760	129	7	production	production	NOUN
ajmsi-1760	129	8	of	of	ADP
ajmsi-1760	129	9	hbs	hbs	PROPN
ajmsi-1760	129	10	rna	rna	PROPN
ajmsi-1760	129	11	and	and	CCONJ
ajmsi-1760	129	12	protein	protein	NOUN
ajmsi-1760	129	13	•	•	NOUN
ajmsi-1760	129	14	production	production	NOUN
ajmsi-1760	129	15	of	of	ADP
ajmsi-1760	129	16	wild	wild	ADJ
ajmsi-1760	129	17	type	type	NOUN
ajmsi-1760	129	18	hemoglobin	hemoglobin	NOUN
ajmsi-1760	129	19	27	27	NUM
ajmsi-1760	129	20	genomic	genomic	NOUN
ajmsi-1760	129	21	editing	editing	NOUN
ajmsi-1760	129	22	for	for	ADP
ajmsi-1760	129	23	sickle	sickle	NOUN
ajmsi-1760	129	24	cell	cell	NOUN
ajmsi-1760	129	25	disease	disease	NOUN
ajmsi-1760	129	26	:	:	PUNCT
ajmsi-1760	129	27	a	a	DET
ajmsi-1760	129	28	little	little	ADJ
ajmsi-1760	129	29	bcl11a	bcl11a	NOUN
ajmsi-1760	129	30	goes	go	VERB
ajmsi-1760	129	31	a	a	DET
ajmsi-1760	129	32	long	long	ADJ
ajmsi-1760	129	33	way	way	NOUN
ajmsi-1760	129	34	(	(	PUNCT
ajmsi-1760	129	35	hossain	hossain	PROPN
ajmsi-1760	129	36	,	,	PUNCT
ajmsi-1760	129	37	2017	2017	NUM
ajmsi-1760	129	38	)	)	PUNCT
ajmsi-1760	129	39	crispr	crispr	NOUN
ajmsi-1760	129	40	-	-	PUNCT
ajmsi-1760	129	41	cas9	cas9	NOUN
ajmsi-1760	129	42	or	or	CCONJ
ajmsi-1760	129	43	zfns	zfns	NOUN
ajmsi-1760	129	44	are	be	AUX
ajmsi-1760	129	45	useful	useful	ADJ
ajmsi-1760	129	46	tools	tool	NOUN
ajmsi-1760	129	47	to	to	PART
ajmsi-1760	129	48	delete	delete	VERB
ajmsi-1760	129	49	or	or	CCONJ
ajmsi-1760	129	50	replace	replace	VERB
ajmsi-1760	129	51	sequences	sequence	NOUN
ajmsi-1760	129	52	involved	involve	VERB
ajmsi-1760	129	53	in	in	ADP
ajmsi-1760	129	54	the	the	DET
ajmsi-1760	129	55	production	production	NOUN
ajmsi-1760	129	56	of	of	ADP
ajmsi-1760	129	57	hemoglobin	hemoglobin	NOUN
ajmsi-1760	129	58	.	.	PUNCT
ajmsi-1760	130	1	review	review	VERB
ajmsi-1760	130	2	•	•	NUM
ajmsi-1760	130	3	feasibility	feasibility	NOUN
ajmsi-1760	130	4	of	of	ADP
ajmsi-1760	130	5	genomic	genomic	NOUN
ajmsi-1760	130	6	editing	editing	NOUN
ajmsi-1760	130	7	in	in	ADP
ajmsi-1760	130	8	hspcs	hspc	NOUN
ajmsi-1760	130	9	•	•	ADP
ajmsi-1760	130	10	ability	ability	NOUN
ajmsi-1760	130	11	of	of	ADP
ajmsi-1760	130	12	crispr	crispr	NOUN
ajmsi-1760	130	13	-	-	PUNCT
ajmsi-1760	130	14	cas9	cas9	NOUN
ajmsi-1760	130	15	or	or	CCONJ
ajmsi-1760	130	16	zfns	zfns	NOUN
ajmsi-1760	130	17	to	to	PART
ajmsi-1760	130	18	delete	delete	VERB
ajmsi-1760	130	19	or	or	CCONJ
ajmsi-1760	130	20	replace	replace	VERB
ajmsi-1760	130	21	sequences	sequence	NOUN
ajmsi-1760	130	22	involved	involve	VERB
ajmsi-1760	130	23	in	in	ADP
ajmsi-1760	130	24	the	the	DET
ajmsi-1760	130	25	production	production	NOUN
ajmsi-1760	130	26	of	of	ADP
ajmsi-1760	130	27	hemoglobin	hemoglobin	NOUN
ajmsi-1760	130	28	pa	pa	PROPN
ajmsi-1760	130	29	ge	ge	PROPN
ajmsi-1760	130	30	51	51	NUM
ajmsi-1760	130	31	https://journals.e-palli.com/home/index.php/ajmsi	https://journals.e-palli.com/home/index.php/ajmsi	PROPN
ajmsi-1760	130	32	am	be	AUX
ajmsi-1760	130	33	.	.	PUNCT
ajmsi-1760	131	1	j.	j.	PROPN
ajmsi-1760	131	2	med	med	PROPN
ajmsi-1760	131	3	.	.	PUNCT
ajmsi-1760	132	1	sci	sci	PROPN
ajmsi-1760	132	2	.	.	PUNCT
ajmsi-1760	132	3	innov	innov	PROPN
ajmsi-1760	132	4	.	.	PUNCT
ajmsi-1760	133	1	2(2	2(2	NUM
ajmsi-1760	133	2	)	)	PUNCT
ajmsi-1760	133	3	44	44	NUM
ajmsi-1760	133	4	-	-	SYM
ajmsi-1760	133	5	56	56	NUM
ajmsi-1760	133	6	,	,	PUNCT
ajmsi-1760	133	7	2023	2023	NUM
ajmsi-1760	133	8	28	28	NUM
ajmsi-1760	133	9	highly	highly	ADV
ajmsi-1760	133	10	efficient	efficient	ADJ
ajmsi-1760	133	11	editing	editing	NOUN
ajmsi-1760	133	12	of	of	ADP
ajmsi-1760	133	13	the	the	DET
ajmsi-1760	133	14	β	β	NOUN
ajmsi-1760	133	15	-	-	ADJ
ajmsi-1760	133	16	globin	globin	ADJ
ajmsi-1760	133	17	gene	gene	NOUN
ajmsi-1760	133	18	in	in	ADP
ajmsi-1760	133	19	patient	patient	NOUN
ajmsi-1760	133	20	-	-	PUNCT
ajmsi-1760	133	21	derived	derive	VERB
ajmsi-1760	133	22	hematopoietic	hematopoietic	ADJ
ajmsi-1760	133	23	stem	stem	NOUN
ajmsi-1760	133	24	and	and	CCONJ
ajmsi-1760	133	25	progenitor	progenitor	NOUN
ajmsi-1760	133	26	cells	cell	NOUN
ajmsi-1760	133	27	to	to	PART
ajmsi-1760	133	28	treat	treat	VERB
ajmsi-1760	133	29	sickle	sickle	NOUN
ajmsi-1760	133	30	cell	cell	NOUN
ajmsi-1760	133	31	disease	disease	NOUN
ajmsi-1760	133	32	(	(	PUNCT
ajmsi-1760	133	33	park	park	NOUN
ajmsi-1760	133	34	,	,	PUNCT
ajmsi-1760	133	35	2019	2019	NUM
ajmsi-1760	133	36	)	)	PUNCT
ajmsi-1760	133	37	gene	gene	NOUN
ajmsi-1760	133	38	-	-	PUNCT
ajmsi-1760	133	39	corrected	correct	VERB
ajmsi-1760	133	40	sickle	sickle	NOUN
ajmsi-1760	133	41	-	-	PUNCT
ajmsi-1760	133	42	cell	cell	NOUN
ajmsi-1760	133	43	hspcs	hspc	NOUN
ajmsi-1760	133	44	engrafted	engraft	VERB
ajmsi-1760	133	45	in	in	ADP
ajmsi-1760	133	46	vivo	vivo	NOUN
ajmsi-1760	133	47	.	.	PUNCT
ajmsi-1760	134	1	e	e	NOUN
ajmsi-1760	134	2	xperim	xperim	VERB
ajmsi-1760	134	3	ental	ental	ADJ
ajmsi-1760	135	1	•	•	NUM
ajmsi-1760	135	2	efficiency	efficiency	NOUN
ajmsi-1760	135	3	of	of	ADP
ajmsi-1760	135	4	correcting	correct	VERB
ajmsi-1760	135	5	the	the	DET
ajmsi-1760	135	6	sickle	sickle	NOUN
ajmsi-1760	135	7	mutation	mutation	NOUN
ajmsi-1760	135	8	in	in	ADP
ajmsi-1760	135	9	the	the	DET
ajmsi-1760	135	10	β	β	NOUN
ajmsi-1760	135	11	-	-	ADJ
ajmsi-1760	135	12	globin	globin	ADJ
ajmsi-1760	135	13	gene	gene	NOUN
ajmsi-1760	135	14	in	in	ADP
ajmsi-1760	135	15	hspcs	hspc	NOUN
ajmsi-1760	135	16	•	•	NOUN
ajmsi-1760	135	17	reduction	reduction	NOUN
ajmsi-1760	135	18	of	of	ADP
ajmsi-1760	135	19	sickle	sickle	NOUN
ajmsi-1760	135	20	cells	cell	NOUN
ajmsi-1760	135	21	in	in	ADP
ajmsi-1760	135	22	erythrocytes	erythrocyte	NOUN
ajmsi-1760	135	23	derived	derive	VERB
ajmsi-1760	135	24	from	from	ADP
ajmsi-1760	135	25	gene	gene	NOUN
ajmsi-1760	135	26	edited	edit	VERB
ajmsi-1760	135	27	cells	cell	NOUN
ajmsi-1760	135	28	•	•	PRON
ajmsi-1760	135	29	level	level	NOUN
ajmsi-1760	135	30	of	of	ADP
ajmsi-1760	135	31	normal	normal	ADJ
ajmsi-1760	135	32	adult	adult	NOUN
ajmsi-1760	135	33	hemoglobin	hemoglobin	NOUN
ajmsi-1760	135	34	(	(	PUNCT
ajmsi-1760	135	35	hba	hba	NOUN
ajmsi-1760	135	36	)	)	PUNCT
ajmsi-1760	135	37	in	in	ADP
ajmsi-1760	135	38	erythrocytes	erythrocyte	NOUN
ajmsi-1760	135	39	derived	derive	VERB
ajmsi-1760	135	40	from	from	ADP
ajmsi-1760	135	41	gene	gene	NOUN
ajmsi-1760	135	42	edited	edit	VERB
ajmsi-1760	135	43	cells	cell	NOUN
ajmsi-1760	135	44	•	•	NUM
ajmsi-1760	135	45	engraftment	engraftment	NOUN
ajmsi-1760	135	46	of	of	ADP
ajmsi-1760	135	47	gene	gene	NOUN
ajmsi-1760	135	48	-	-	PUNCT
ajmsi-1760	135	49	edited	edit	VERB
ajmsi-1760	135	50	scd	scd	NOUN
ajmsi-1760	135	51	hspcs	hspc	NOUN
ajmsi-1760	135	52	in	in	ADP
ajmsi-1760	135	53	non	non	ADJ
ajmsi-1760	135	54	-	-	ADJ
ajmsi-1760	135	55	obese	obese	ADJ
ajmsi-1760	135	56	diabetic	diabetic	ADJ
ajmsi-1760	135	57	(	(	PUNCT
ajmsi-1760	135	58	nod	nod	PROPN
ajmsi-1760	135	59	)	)	PUNCT
ajmsi-1760	135	60	scid	scid	PROPN
ajmsi-1760	135	61	gamma	gamma	PROPN
ajmsi-1760	135	62	(	(	PUNCT
ajmsi-1760	135	63	nsg	nsg	PROPN
ajmsi-1760	135	64	)	)	PUNCT
ajmsi-1760	135	65	mice	mouse	NOUN
ajmsi-1760	135	66	29	29	NUM
ajmsi-1760	135	67	cas9	cas9	NOUN
ajmsi-1760	135	68	protein	protein	NOUN
ajmsi-1760	135	69	delivery	delivery	NOUN
ajmsi-1760	135	70	non	non	ADJ
ajmsi-1760	135	71	-	-	ADJ
ajmsi-1760	135	72	integrating	integrating	ADJ
ajmsi-1760	135	73	lentiviralvectors	lentiviralvector	NOUN
ajmsi-1760	135	74	for	for	ADP
ajmsi-1760	135	75	gene	gene	NOUN
ajmsi-1760	135	76	correction	correction	NOUN
ajmsi-1760	135	77	in	in	ADP
ajmsi-1760	135	78	sickle	sickle	NOUN
ajmsi-1760	135	79	cell	cell	NOUN
ajmsi-1760	135	80	disease	disease	NOUN
ajmsi-1760	135	81	(	(	PUNCT
ajmsi-1760	135	82	uchida	uchida	PROPN
ajmsi-1760	135	83	,	,	PUNCT
ajmsi-1760	135	84	2021	2021	NUM
ajmsi-1760	135	85	)	)	PUNCT
ajmsi-1760	135	86	the	the	DET
ajmsi-1760	135	87	cas9	cas9	NOUN
ajmsi-1760	135	88	protein	protein	NOUN
ajmsi-1760	135	89	delivery	delivery	NOUN
ajmsi-1760	135	90	nonintegrating	nonintegrate	VERB
ajmsi-1760	135	91	lentiviral	lentiviral	ADJ
ajmsi-1760	135	92	all	all	ADV
ajmsi-1760	135	93	-	-	PUNCT
ajmsi-1760	135	94	in	in	ADP
ajmsi-1760	135	95	-	-	PUNCT
ajmsi-1760	135	96	one	one	NUM
ajmsi-1760	135	97	system	system	NOUN
ajmsi-1760	135	98	efficiently	efficiently	ADV
ajmsi-1760	135	99	corrected	correct	VERB
ajmsi-1760	135	100	the	the	DET
ajmsi-1760	135	101	scd	scd	NOUN
ajmsi-1760	135	102	mutation	mutation	NOUN
ajmsi-1760	135	103	in	in	ADP
ajmsi-1760	135	104	the	the	DET
ajmsi-1760	135	105	endogenous	endogenous	ADJ
ajmsi-1760	135	106	s	s	NOUN
ajmsi-1760	135	107	-	-	PUNCT
ajmsi-1760	135	108	globin	globin	ADJ
ajmsi-1760	135	109	gene	gene	NOUN
ajmsi-1760	135	110	without	without	ADP
ajmsi-1760	135	111	electroporation	electroporation	NOUN
ajmsi-1760	135	112	.	.	PUNCT
ajmsi-1760	136	1	e	e	NOUN
ajmsi-1760	136	2	xperim	xperim	VERB
ajmsi-1760	136	3	ental	ental	ADJ
ajmsi-1760	137	1	•	•	NUM
ajmsi-1760	137	2	efficiency	efficiency	NOUN
ajmsi-1760	137	3	of	of	ADP
ajmsi-1760	137	4	correction	correction	NOUN
ajmsi-1760	137	5	of	of	ADP
ajmsi-1760	137	6	the	the	DET
ajmsi-1760	137	7	scd	scd	NOUN
ajmsi-1760	137	8	mutation	mutation	NOUN
ajmsi-1760	137	9	in	in	ADP
ajmsi-1760	137	10	the	the	DET
ajmsi-1760	137	11	endogenous	endogenous	ADJ
ajmsi-1760	137	12	β	β	X
ajmsi-1760	137	13	-	-	ADJ
ajmsi-1760	137	14	globin	globin	ADJ
ajmsi-1760	137	15	genes	gene	NOUN
ajmsi-1760	137	16	•	•	PRON
ajmsi-1760	137	17	protein	protein	NOUN
ajmsi-1760	137	18	level	level	NOUN
ajmsi-1760	137	19	of	of	ADP
ajmsi-1760	137	20	the	the	DET
ajmsi-1760	137	21	corrected	correct	VERB
ajmsi-1760	137	22	β	β	NOUN
ajmsi-1760	137	23	-	-	ADJ
ajmsi-1760	137	24	globin	globin	ADJ
ajmsi-1760	137	25	genes	gene	NOUN
ajmsi-1760	137	26	30	30	NUM
ajmsi-1760	137	27	application	application	NOUN
ajmsi-1760	137	28	of	of	ADP
ajmsi-1760	137	29	crisprcas9	crisprcas9	NOUN
ajmsi-1760	137	30	genomic	genomic	NOUN
ajmsi-1760	137	31	editing	editing	NOUN
ajmsi-1760	137	32	in	in	ADP
ajmsi-1760	137	33	genetic	genetic	ADJ
ajmsi-1760	137	34	disorders	disorder	NOUN
ajmsi-1760	137	35	:	:	PUNCT
ajmsi-1760	137	36	a	a	DET
ajmsi-1760	137	37	systematic	systematic	ADJ
ajmsi-1760	137	38	review	review	NOUN
ajmsi-1760	137	39	up	up	ADP
ajmsi-1760	137	40	to	to	ADP
ajmsi-1760	137	41	date	date	NOUN
ajmsi-1760	137	42	(	(	PUNCT
ajmsi-1760	137	43	pandey	pandey	PROPN
ajmsi-1760	137	44	,	,	PUNCT
ajmsi-1760	137	45	2017	2017	NUM
ajmsi-1760	137	46	)	)	PUNCT
ajmsi-1760	137	47	crispr	crispr	ADJ
ajmsi-1760	137	48	-	-	PUNCT
ajmsi-1760	137	49	cas9	cas9	NOUN
ajmsi-1760	137	50	system	system	NOUN
ajmsi-1760	137	51	has	have	AUX
ajmsi-1760	137	52	been	be	AUX
ajmsi-1760	137	53	used	use	VERB
ajmsi-1760	137	54	from	from	ADP
ajmsi-1760	137	55	last	last	ADJ
ajmsi-1760	137	56	few	few	ADJ
ajmsi-1760	137	57	years	year	NOUN
ajmsi-1760	137	58	in	in	ADP
ajmsi-1760	137	59	the	the	DET
ajmsi-1760	137	60	field	field	NOUN
ajmsi-1760	137	61	of	of	ADP
ajmsi-1760	137	62	biomedical	biomedical	ADJ
ajmsi-1760	137	63	research	research	NOUN
ajmsi-1760	137	64	.	.	PUNCT
ajmsi-1760	138	1	review	review	VERB
ajmsi-1760	138	2	•	•	NUM
ajmsi-1760	138	3	genomic	genomic	NOUN
ajmsi-1760	138	4	editing	editing	NOUN
ajmsi-1760	138	5	technologies	technology	NOUN
ajmsi-1760	138	6	over	over	ADP
ajmsi-1760	138	7	the	the	DET
ajmsi-1760	138	8	past	past	ADJ
ajmsi-1760	138	9	few	few	ADJ
ajmsi-1760	138	10	years	year	NOUN
ajmsi-1760	138	11	is	be	AUX
ajmsi-1760	138	12	providing	provide	VERB
ajmsi-1760	138	13	fast	fast	ADJ
ajmsi-1760	138	14	and	and	CCONJ
ajmsi-1760	138	15	effective	effective	ADJ
ajmsi-1760	138	16	tool	tool	NOUN
ajmsi-1760	138	17	to	to	PART
ajmsi-1760	138	18	precisely	precisely	ADV
ajmsi-1760	138	19	manipulate	manipulate	VERB
ajmsi-1760	138	20	the	the	DET
ajmsi-1760	138	21	genome	genome	NOUN
ajmsi-1760	138	22	at	at	ADP
ajmsi-1760	138	23	specific	specific	ADJ
ajmsi-1760	138	24	locations	location	NOUN
ajmsi-1760	138	25	.	.	PUNCT
ajmsi-1760	139	1	31	31	NUM
ajmsi-1760	139	2	development	development	NOUN
ajmsi-1760	139	3	of	of	ADP
ajmsi-1760	139	4	β	β	ADJ
ajmsi-1760	139	5	-	-	ADJ
ajmsi-1760	139	6	globin	globin	ADJ
ajmsi-1760	139	7	gene	gene	NOUN
ajmsi-1760	139	8	correction	correction	NOUN
ajmsi-1760	139	9	in	in	ADP
ajmsi-1760	139	10	human	human	ADJ
ajmsi-1760	139	11	hematopoietic	hematopoietic	ADJ
ajmsi-1760	139	12	stem	stem	NOUN
ajmsi-1760	139	13	cells	cell	NOUN
ajmsi-1760	139	14	as	as	ADP
ajmsi-1760	139	15	a	a	DET
ajmsi-1760	139	16	potential	potential	ADJ
ajmsi-1760	139	17	durable	durable	ADJ
ajmsi-1760	139	18	treatment	treatment	NOUN
ajmsi-1760	139	19	for	for	ADP
ajmsi-1760	139	20	sickle	sickle	NOUN
ajmsi-1760	139	21	cell	cell	NOUN
ajmsi-1760	139	22	disease	disease	NOUN
ajmsi-1760	139	23	(	(	PUNCT
ajmsi-1760	139	24	lattanzi	lattanzi	ADJ
ajmsi-1760	139	25	,	,	PUNCT
ajmsi-1760	139	26	2021	2021	NUM
ajmsi-1760	139	27	)	)	PUNCT
ajmsi-1760	139	28	ex	ex	PRON
ajmsi-1760	139	29	vivo	vivo	ADJ
ajmsi-1760	139	30	β	β	NOUN
ajmsi-1760	139	31	-	-	ADJ
ajmsi-1760	139	32	globin	globin	ADJ
ajmsi-1760	139	33	gene	gene	NOUN
ajmsi-1760	139	34	correction	correction	NOUN
ajmsi-1760	139	35	in	in	ADP
ajmsi-1760	139	36	autologous	autologous	ADJ
ajmsi-1760	139	37	patient	patient	NOUN
ajmsi-1760	139	38	-	-	PUNCT
ajmsi-1760	139	39	derived	derive	VERB
ajmsi-1760	139	40	hspcs	hspc	NOUN
ajmsi-1760	139	41	may	may	AUX
ajmsi-1760	139	42	potentially	potentially	ADV
ajmsi-1760	139	43	provide	provide	VERB
ajmsi-1760	139	44	a	a	DET
ajmsi-1760	139	45	curative	curative	ADJ
ajmsi-1760	139	46	treatment	treatment	NOUN
ajmsi-1760	139	47	for	for	ADP
ajmsi-1760	139	48	scd	scd	NOUN
ajmsi-1760	139	49	.	.	PUNCT
ajmsi-1760	140	1	phase	phase	NOUN
ajmsi-1760	140	2	1/2	1/2	NUM
ajmsi-1760	140	3	•	•	NOUN
ajmsi-1760	140	4	gene	gene	NOUN
ajmsi-1760	140	5	correction	correction	NOUN
ajmsi-1760	140	6	•	•	ADP
ajmsi-1760	140	7	genotoxicity	genotoxicity	NOUN
ajmsi-1760	140	8	•	•	NOUN
ajmsi-1760	140	9	tumorigenicity	tumorigenicity	NOUN
ajmsi-1760	140	10	•	•	NOUN
ajmsi-1760	140	11	multilineage	multilineage	NOUN
ajmsi-1760	140	12	engraftment	engraftment	VERB
ajmsi-1760	140	13	•	•	NUM
ajmsi-1760	140	14	abnormal	abnormal	ADJ
ajmsi-1760	140	15	hematopoiesis	hematopoiesis	NOUN
ajmsi-1760	140	16	•	•	NOUN
ajmsi-1760	140	17	toxicology	toxicology	NOUN
ajmsi-1760	140	18	32	32	NUM
ajmsi-1760	140	19	combination	combination	NOUN
ajmsi-1760	140	20	of	of	ADP
ajmsi-1760	140	21	lentiviral	lentiviral	ADJ
ajmsi-1760	140	22	and	and	CCONJ
ajmsi-1760	140	23	genomic	genomic	NOUN
ajmsi-1760	140	24	editing	editing	NOUN
ajmsi-1760	140	25	technologies	technology	NOUN
ajmsi-1760	140	26	for	for	ADP
ajmsi-1760	140	27	the	the	DET
ajmsi-1760	140	28	treatment	treatment	NOUN
ajmsi-1760	140	29	of	of	ADP
ajmsi-1760	140	30	sickle	sickle	NOUN
ajmsi-1760	140	31	cell	cell	NOUN
ajmsi-1760	140	32	disease	disease	NOUN
ajmsi-1760	140	33	(	(	PUNCT
ajmsi-1760	140	34	ramadier	ramadier	NOUN
ajmsi-1760	140	35	,	,	PUNCT
ajmsi-1760	140	36	2022	2022	NUM
ajmsi-1760	140	37	)	)	PUNCT
ajmsi-1760	140	38	transduced	transduce	VERB
ajmsi-1760	140	39	cells	cell	NOUN
ajmsi-1760	140	40	from	from	ADP
ajmsi-1760	140	41	sickle	sickle	NOUN
ajmsi-1760	140	42	cell	cell	NOUN
ajmsi-1760	140	43	patients	patient	NOUN
ajmsi-1760	140	44	were	be	AUX
ajmsi-1760	140	45	transduced	transduce	VERB
ajmsi-1760	140	46	with	with	ADP
ajmsi-1760	140	47	lentiviral	lentiviral	ADJ
ajmsi-1760	140	48	vectors	vector	NOUN
ajmsi-1760	140	49	expressing	express	VERB
ajmsi-1760	140	50	as3	as3	PROPN
ajmsi-1760	140	51	and	and	CCONJ
ajmsi-1760	140	52	a	a	DET
ajmsi-1760	140	53	guiderna	guiderna	NOUN
ajmsi-1760	140	54	either	either	CCONJ
ajmsi-1760	140	55	targeting	target	VERB
ajmsi-1760	140	56	the	the	DET
ajmsi-1760	140	57	endogenous	endogenous	ADJ
ajmsi-1760	140	58	β	β	ADJ
ajmsi-1760	140	59	-	-	ADJ
ajmsi-1760	140	60	globin	globin	ADJ
ajmsi-1760	140	61	gene	gene	NOUN
ajmsi-1760	140	62	or	or	CCONJ
ajmsi-1760	140	63	regions	region	NOUN
ajmsi-1760	140	64	involved	involve	VERB
ajmsi-1760	140	65	in	in	ADP
ajmsi-1760	140	66	hbf	hbf	PROPN
ajmsi-1760	140	67	silencing	silencing	NOUN
ajmsi-1760	140	68	.	.	PUNCT
ajmsi-1760	141	1	e	e	NOUN
ajmsi-1760	141	2	xperim	xperim	VERB
ajmsi-1760	141	3	ental	ental	ADJ
ajmsi-1760	141	4	•	•	NUM
ajmsi-1760	141	5	clinical	clinical	ADJ
ajmsi-1760	141	6	benefit	benefit	NOUN
ajmsi-1760	141	7	in	in	ADP
ajmsi-1760	141	8	scd	scd	NOUN
ajmsi-1760	141	9	patients	patient	NOUN
ajmsi-1760	141	10	•	•	NOUN
ajmsi-1760	141	11	vector	vector	NOUN
ajmsi-1760	141	12	copy	copy	NOUN
ajmsi-1760	141	13	number	number	NOUN
ajmsi-1760	141	14	(	(	PUNCT
ajmsi-1760	141	15	vcn	vcn	PROPN
ajmsi-1760	141	16	)	)	PUNCT
ajmsi-1760	141	17	•	•	ADP
ajmsi-1760	141	18	anti	anti	ADJ
ajmsi-1760	141	19	-	-	ADJ
ajmsi-1760	141	20	sickling	sickling	ADJ
ajmsi-1760	141	21	hemoglobins	hemoglobin	NOUN
ajmsi-1760	141	22	•	•	ADP
ajmsi-1760	141	23	rescue	rescue	NOUN
ajmsi-1760	141	24	of	of	ADP
ajmsi-1760	141	25	the	the	DET
ajmsi-1760	141	26	scd	scd	NOUN
ajmsi-1760	141	27	phenotype	phenotype	NOUN
ajmsi-1760	141	28	•	•	NOUN
ajmsi-1760	141	29	genotoxicity	genotoxicity	NOUN
ajmsi-1760	141	30	risk	risk	NOUN
ajmsi-1760	141	31	table	table	NOUN
ajmsi-1760	141	32	2	2	NUM
ajmsi-1760	141	33	:	:	PUNCT
ajmsi-1760	141	34	current	current	ADJ
ajmsi-1760	141	35	clinical	clinical	ADJ
ajmsi-1760	141	36	trials	trial	NOUN
ajmsi-1760	141	37	on	on	ADP
ajmsi-1760	141	38	crispr	crispr	NOUN
ajmsi-1760	141	39	-	-	PUNCT
ajmsi-1760	141	40	cas	cas	NOUN
ajmsi-1760	141	41	9	9	NUM
ajmsi-1760	141	42	(	(	PUNCT
ajmsi-1760	141	43	from	from	ADP
ajmsi-1760	141	44	clinicaltrial.gov	clinicaltrial.gov	VERB
ajmsi-1760	141	45	,	,	PUNCT
ajmsi-1760	141	46	assessed	assess	VERB
ajmsi-1760	141	47	on	on	ADP
ajmsi-1760	141	48	april	april	PROPN
ajmsi-1760	141	49	5th	5th	NOUN
ajmsi-1760	141	50	,	,	PUNCT
ajmsi-1760	141	51	2023	2023	NUM
ajmsi-1760	141	52	)	)	PUNCT
ajmsi-1760	141	53	s	s	X
ajmsi-1760	141	54	/	/	SYM
ajmsi-1760	141	55	n	n	PRON
ajmsi-1760	141	56	study	study	NOUN
ajmsi-1760	141	57	title	title	NOUN
ajmsi-1760	141	58	conditions	condition	NOUN
ajmsi-1760	141	59	interventions	intervention	NOUN
ajmsi-1760	141	60	locations	location	NOUN
ajmsi-1760	141	61	(	(	PUNCT
ajmsi-1760	141	62	first	first	ADJ
ajmsi-1760	141	63	3	3	NUM
ajmsi-1760	141	64	)	)	PUNCT
ajmsi-1760	141	65	1	1	NUM
ajmsi-1760	141	66	a	a	DET
ajmsi-1760	141	67	safety	safety	NOUN
ajmsi-1760	141	68	and	and	CCONJ
ajmsi-1760	141	69	efficacy	efficacy	NOUN
ajmsi-1760	141	70	study	study	NOUN
ajmsi-1760	141	71	evaluating	evaluate	VERB
ajmsi-1760	141	72	ctx001	ctx001	PROPN
ajmsi-1760	141	73	in	in	ADP
ajmsi-1760	141	74	subjects	subject	NOUN
ajmsi-1760	141	75	with	with	ADP
ajmsi-1760	141	76	severe	severe	ADJ
ajmsi-1760	141	77	sickle	sickle	NOUN
ajmsi-1760	141	78	cell	cell	NOUN
ajmsi-1760	141	79	disease	disease	NOUN
ajmsi-1760	141	80	•	•	NOUN
ajmsi-1760	141	81	sickle	sickle	NOUN
ajmsi-1760	141	82	cell	cell	NOUN
ajmsi-1760	141	83	disease	disease	NOUN
ajmsi-1760	141	84	•hematological	•hematological	PROPN
ajmsi-1760	141	85	diseases	disease	NOUN
ajmsi-1760	141	86	•hemoglobinopathies	•hemoglobinopathie	NOUN
ajmsi-1760	141	87	•	•	NOUN
ajmsi-1760	141	88	biological	biological	ADJ
ajmsi-1760	141	89	:	:	PUNCT
ajmsi-1760	141	90	ctx001	ctx001	ADJ
ajmsi-1760	141	91	•	•	NOUN
ajmsi-1760	141	92	phase	phase	NOUN
ajmsi-1760	141	93	1/2/3	1/2/3	NUM
ajmsi-1760	141	94	study	study	NOUN
ajmsi-1760	141	95	•	•	NOUN
ajmsi-1760	141	96	45	45	NUM
ajmsi-1760	141	97	estimated	estimate	VERB
ajmsi-1760	141	98	participants	participant	NOUN
ajmsi-1760	141	99	1	1	NUM
ajmsi-1760	141	100	.	.	PUNCT
ajmsi-1760	142	1	lucille	lucille	PROPN
ajmsi-1760	142	2	packard	packard	PROPN
ajmsi-1760	142	3	children	children	PROPN
ajmsi-1760	142	4	’s	’s	PART
ajmsi-1760	142	5	hospital	hospital	NOUN
ajmsi-1760	142	6	of	of	ADP
ajmsi-1760	142	7	stanford	stanford	PROPN
ajmsi-1760	142	8	university	university	PROPN
ajmsi-1760	142	9	,	,	PUNCT
ajmsi-1760	142	10	palo	palo	PROPN
ajmsi-1760	142	11	alto	alto	PROPN
ajmsi-1760	142	12	,	,	PUNCT
ajmsi-1760	142	13	california	california	PROPN
ajmsi-1760	142	14	,	,	PUNCT
ajmsi-1760	142	15	united	united	PROPN
ajmsi-1760	142	16	states	states	PROPN
ajmsi-1760	142	17	.	.	PUNCT
ajmsi-1760	143	1	2	2	X
ajmsi-1760	143	2	.	.	X
ajmsi-1760	143	3	ann	ann	PROPN
ajmsi-1760	143	4	&	&	CCONJ
ajmsi-1760	143	5	robert	robert	PROPN
ajmsi-1760	143	6	lurie	lurie	PROPN
ajmsi-1760	143	7	children	children	PROPN
ajmsi-1760	143	8	’s	’s	PART
ajmsi-1760	143	9	hospital	hospital	NOUN
ajmsi-1760	143	10	of	of	ADP
ajmsi-1760	143	11	chicago	chicago	PROPN
ajmsi-1760	143	12	,	,	PUNCT
ajmsi-1760	143	13	chicago	chicago	PROPN
ajmsi-1760	143	14	,	,	PUNCT
ajmsi-1760	143	15	illinois	illinois	PROPN
ajmsi-1760	143	16	,	,	PUNCT
ajmsi-1760	143	17	united	united	PROPN
ajmsi-1760	143	18	states	states	PROPN
ajmsi-1760	143	19	.	.	PUNCT
ajmsi-1760	144	1	3	3	X
ajmsi-1760	144	2	.	.	X
ajmsi-1760	144	3	university	university	NOUN
ajmsi-1760	144	4	of	of	ADP
ajmsi-1760	144	5	illinois	illinois	PROPN
ajmsi-1760	144	6	at	at	ADP
ajmsi-1760	144	7	chicago	chicago	PROPN
ajmsi-1760	144	8	hospitals	hospital	NOUN
ajmsi-1760	144	9	and	and	CCONJ
ajmsi-1760	144	10	health	health	NOUN
ajmsi-1760	144	11	systems	system	NOUN
ajmsi-1760	144	12	,	,	PUNCT
ajmsi-1760	144	13	chicago	chicago	PROPN
ajmsi-1760	144	14	,	,	PUNCT
ajmsi-1760	144	15	illinois	illinois	PROPN
ajmsi-1760	144	16	,	,	PUNCT
ajmsi-1760	144	17	united	united	PROPN
ajmsi-1760	144	18	states	states	PROPN
ajmsi-1760	144	19	.	.	PUNCT
ajmsi-1760	145	1	pa	pa	PROPN
ajmsi-1760	145	2	ge	ge	PROPN
ajmsi-1760	145	3	52	52	NUM
ajmsi-1760	145	4	https://journals.e-palli.com/home/index.php/ajmsi	https://journals.e-palli.com/home/index.php/ajmsi	PROPN
ajmsi-1760	145	5	am	be	AUX
ajmsi-1760	145	6	.	.	PUNCT
ajmsi-1760	146	1	j.	j.	PROPN
ajmsi-1760	146	2	med	med	PROPN
ajmsi-1760	146	3	.	.	PUNCT
ajmsi-1760	147	1	sci	sci	PROPN
ajmsi-1760	147	2	.	.	PUNCT
ajmsi-1760	147	3	innov	innov	PROPN
ajmsi-1760	147	4	.	.	PUNCT
ajmsi-1760	148	1	2(2	2(2	NUM
ajmsi-1760	148	2	)	)	PUNCT
ajmsi-1760	148	3	44	44	NUM
ajmsi-1760	148	4	-	-	SYM
ajmsi-1760	148	5	56	56	NUM
ajmsi-1760	148	6	,	,	PUNCT
ajmsi-1760	148	7	2023	2023	NUM
ajmsi-1760	148	8	2	2	NUM
ajmsi-1760	148	9	evaluation	evaluation	NOUN
ajmsi-1760	148	10	of	of	ADP
ajmsi-1760	148	11	efficacy	efficacy	NOUN
ajmsi-1760	148	12	and	and	CCONJ
ajmsi-1760	148	13	safety	safety	NOUN
ajmsi-1760	148	14	of	of	ADP
ajmsi-1760	148	15	a	a	DET
ajmsi-1760	148	16	single	single	ADJ
ajmsi-1760	148	17	dose	dose	NOUN
ajmsi-1760	148	18	of	of	ADP
ajmsi-1760	148	19	ctx001	ctx001	PROPN
ajmsi-1760	148	20	in	in	ADP
ajmsi-1760	148	21	participants	participant	NOUN
ajmsi-1760	148	22	with	with	ADP
ajmsi-1760	148	23	transfusiondependent	transfusiondependent	ADJ
ajmsi-1760	148	24	beta	beta	NOUN
ajmsi-1760	148	25	thalassemia	thalassemia	NOUN
ajmsi-1760	148	26	and	and	CCONJ
ajmsi-1760	148	27	severe	severe	ADJ
ajmsi-1760	148	28	sickle	sickle	NOUN
ajmsi-1760	148	29	cell	cell	NOUN
ajmsi-1760	148	30	disease	disease	NOUN
ajmsi-1760	148	31	•	•	ADP
ajmsi-1760	148	32	β	β	X
ajmsi-1760	148	33	-	-	NOUN
ajmsi-1760	148	34	thalassemia	thalassemia	NOUN
ajmsi-1760	148	35	•	•	NOUN
ajmsi-1760	148	36	thalassemia	thalassemia	NOUN
ajmsi-1760	148	37	•	•	PRON
ajmsi-1760	148	38	hematologic	hematologic	NOUN
ajmsi-1760	148	39	disease	disease	NOUN
ajmsi-1760	148	40	•	•	NOUN
ajmsi-1760	148	41	biological	biological	NOUN
ajmsi-1760	148	42	:	:	PUNCT
ajmsi-1760	148	43	ctx001	ctx001	ADJ
ajmsi-1760	148	44	•	•	NOUN
ajmsi-1760	148	45	phase	phase	NOUN
ajmsi-1760	148	46	3	3	NUM
ajmsi-1760	148	47	•	•	NOUN
ajmsi-1760	148	48	12	12	NUM
ajmsi-1760	148	49	estimated	estimate	VERB
ajmsi-1760	148	50	participants	participant	NOUN
ajmsi-1760	148	51	1.columbia	1.columbia	NUM
ajmsi-1760	148	52	university	university	NOUN
ajmsi-1760	148	53	medical	medical	ADJ
ajmsi-1760	148	54	center	center	NOUN
ajmsi-1760	148	55	,	,	PUNCT
ajmsi-1760	148	56	new	new	PROPN
ajmsi-1760	148	57	york	york	PROPN
ajmsi-1760	148	58	,	,	PUNCT
ajmsi-1760	148	59	united	united	PROPN
ajmsi-1760	148	60	states	states	PROPN
ajmsi-1760	148	61	.	.	PUNCT
ajmsi-1760	149	1	2	2	X
ajmsi-1760	149	2	.	.	X
ajmsi-1760	149	3	atrium	atrium	PROPN
ajmsi-1760	149	4	health	health	PROPN
ajmsi-1760	149	5	levine	levine	PROPN
ajmsi-1760	149	6	children	children	PROPN
ajmsi-1760	149	7	’s	’s	PART
ajmsi-1760	149	8	hospital	hospital	NOUN
ajmsi-1760	149	9	,	,	PUNCT
ajmsi-1760	149	10	charlotte	charlotte	PROPN
ajmsi-1760	149	11	,	,	PUNCT
ajmsi-1760	149	12	north	north	PROPN
ajmsi-1760	149	13	carolina	carolina	PROPN
ajmsi-1760	149	14	,	,	PUNCT
ajmsi-1760	149	15	united	united	PROPN
ajmsi-1760	149	16	states	states	PROPN
ajmsi-1760	149	17	.	.	PUNCT
ajmsi-1760	150	1	3	3	X
ajmsi-1760	150	2	.	.	X
ajmsi-1760	150	3	scri	scri	PROPN
ajmsi-1760	150	4	at	at	ADP
ajmsi-1760	150	5	the	the	DET
ajmsi-1760	150	6	children	child	NOUN
ajmsi-1760	150	7	’s	’s	PART
ajmsi-1760	150	8	hospital	hospital	NOUN
ajmsi-1760	150	9	at	at	ADP
ajmsi-1760	150	10	tristar	tristar	PROPN
ajmsi-1760	150	11	centennial	centennial	PROPN
ajmsi-1760	150	12	,	,	PUNCT
ajmsi-1760	150	13	nashville	nashville	PROPN
ajmsi-1760	150	14	,	,	PUNCT
ajmsi-1760	150	15	tennessee	tennessee	PROPN
ajmsi-1760	150	16	,	,	PUNCT
ajmsi-1760	150	17	united	united	PROPN
ajmsi-1760	150	18	states	states	PROPN
ajmsi-1760	150	19	.	.	PUNCT
ajmsi-1760	151	1	3	3	NUM
ajmsi-1760	151	2	evaluation	evaluation	NOUN
ajmsi-1760	151	3	of	of	ADP
ajmsi-1760	151	4	safety	safety	NOUN
ajmsi-1760	151	5	and	and	CCONJ
ajmsi-1760	151	6	efficacy	efficacy	NOUN
ajmsi-1760	151	7	of	of	ADP
ajmsi-1760	151	8	ctx001	ctx001	PROPN
ajmsi-1760	151	9	in	in	ADP
ajmsi-1760	151	10	pediatric	pediatric	ADJ
ajmsi-1760	151	11	participants	participant	NOUN
ajmsi-1760	151	12	with	with	ADP
ajmsi-1760	151	13	severe	severe	ADJ
ajmsi-1760	151	14	scd	scd	PROPN
ajmsi-1760	151	15	•	•	PROPN
ajmsi-1760	151	16	scd	scd	PROPN
ajmsi-1760	151	17	•	•	PROPN
ajmsi-1760	151	18	hydroxyurea	hydroxyurea	PROPN
ajmsi-1760	151	19	failure	failure	NOUN
ajmsi-1760	151	20	•hydroxyurea	•hydroxyurea	PROPN
ajmsi-1760	151	21	intolerance	intolerance	NOUN
ajmsi-1760	151	22	•	•	NOUN
ajmsi-1760	151	23	biological	biological	NOUN
ajmsi-1760	151	24	:	:	PUNCT
ajmsi-1760	151	25	ctx001	ctx001	ADJ
ajmsi-1760	151	26	•	•	NOUN
ajmsi-1760	151	27	phase	phase	NOUN
ajmsi-1760	151	28	3	3	NUM
ajmsi-1760	151	29	•	•	NOUN
ajmsi-1760	151	30	12	12	NUM
ajmsi-1760	151	31	estimated	estimate	VERB
ajmsi-1760	151	32	participants	participant	NOUN
ajmsi-1760	151	33	1	1	NUM
ajmsi-1760	151	34	.	.	PUNCT
ajmsi-1760	152	1	children	child	NOUN
ajmsi-1760	152	2	’s	’s	PART
ajmsi-1760	152	3	hospital	hospital	NOUN
ajmsi-1760	152	4	of	of	ADP
ajmsi-1760	152	5	philadelphia	philadelphia	PROPN
ajmsi-1760	152	6	,	,	PUNCT
ajmsi-1760	152	7	philadelphia	philadelphia	PROPN
ajmsi-1760	152	8	,	,	PUNCT
ajmsi-1760	152	9	pennsylvania	pennsylvania	PROPN
ajmsi-1760	152	10	,	,	PUNCT
ajmsi-1760	152	11	united	united	PROPN
ajmsi-1760	152	12	states	states	PROPN
ajmsi-1760	152	13	.	.	PUNCT
ajmsi-1760	153	1	2	2	X
ajmsi-1760	153	2	.	.	X
ajmsi-1760	153	3	st	st	PROPN
ajmsi-1760	153	4	.	.	PROPN
ajmsi-1760	153	5	jude	jude	PROPN
ajmsi-1760	153	6	children	children	PROPN
ajmsi-1760	153	7	’s	’s	PART
ajmsi-1760	153	8	research	research	NOUN
ajmsi-1760	153	9	hospital	hospital	NOUN
ajmsi-1760	153	10	,	,	PUNCT
ajmsi-1760	153	11	memphis	memphis	PROPN
ajmsi-1760	153	12	,	,	PUNCT
ajmsi-1760	153	13	tennessee	tennessee	PROPN
ajmsi-1760	153	14	,	,	PUNCT
ajmsi-1760	153	15	united	united	PROPN
ajmsi-1760	153	16	states	states	PROPN
ajmsi-1760	153	17	.	.	PUNCT
ajmsi-1760	154	1	3	3	X
ajmsi-1760	154	2	.	.	X
ajmsi-1760	154	3	the	the	DET
ajmsi-1760	154	4	children	child	NOUN
ajmsi-1760	154	5	’s	’s	PART
ajmsi-1760	154	6	hospital	hospital	NOUN
ajmsi-1760	154	7	at	at	ADP
ajmsi-1760	154	8	tristar	tristar	PROPN
ajmsi-1760	154	9	centennial	centennial	PROPN
ajmsi-1760	154	10	medical	medical	PROPN
ajmsi-1760	154	11	center/	center/	PROPN
ajmsi-1760	154	12	sarah	sarah	PROPN
ajmsi-1760	154	13	cannon	cannon	NOUN
ajmsi-1760	154	14	center	center	NOUN
ajmsi-1760	154	15	for	for	ADP
ajmsi-1760	154	16	blood	blood	NOUN
ajmsi-1760	154	17	cancers	cancer	NOUN
ajmsi-1760	154	18	.	.	PUNCT
ajmsi-1760	155	1	4	4	NUM
ajmsi-1760	155	2	transplantation	transplantation	NOUN
ajmsi-1760	155	3	of	of	ADP
ajmsi-1760	155	4	crisprmodified	crisprmodifie	VERB
ajmsi-1760	155	5	hematopoietic	hematopoietic	ADJ
ajmsi-1760	155	6	progenitor	progenitor	NOUN
ajmsi-1760	155	7	stem	stem	NOUN
ajmsi-1760	155	8	cells	cell	NOUN
ajmsi-1760	155	9	(	(	PUNCT
ajmsi-1760	155	10	crispr	crispr	NOUN
ajmsi-1760	155	11	-	-	PUNCT
ajmsi-1760	155	12	scd	scd	NOUN
ajmsi-1760	155	13	001	001	NUM
ajmsi-1760	155	14	)	)	PUNCT
ajmsi-1760	155	15	in	in	ADP
ajmsi-1760	155	16	patients	patient	NOUN
ajmsi-1760	155	17	with	with	ADP
ajmsi-1760	155	18	severe	severe	ADJ
ajmsi-1760	155	19	sickle	sickle	NOUN
ajmsi-1760	155	20	cell	cell	NOUN
ajmsi-1760	155	21	disease	disease	NOUN
ajmsi-1760	155	22	•	•	NUM
ajmsi-1760	155	23	scd	scd	PROPN
ajmsi-1760	155	24	•	•	NOUN
ajmsi-1760	155	25	drug	drug	NOUN
ajmsi-1760	155	26	:	:	PUNCT
ajmsi-1760	155	27	crispr	crispr	PROPN
ajmsi-1760	155	28	_	_	PUNCT
ajmsi-1760	155	29	scd001	scd001	NOUN
ajmsi-1760	155	30	•	•	NOUN
ajmsi-1760	155	31	phase	phase	NOUN
ajmsi-1760	155	32	1/2	1/2	NUM
ajmsi-1760	155	33	•	•	NOUN
ajmsi-1760	155	34	9	9	NUM
ajmsi-1760	155	35	estimated	estimate	VERB
ajmsi-1760	155	36	participants	participant	NOUN
ajmsi-1760	155	37	1	1	NUM
ajmsi-1760	155	38	.	.	PUNCT
ajmsi-1760	156	1	university	university	PROPN
ajmsi-1760	156	2	of	of	ADP
ajmsi-1760	156	3	california	california	PROPN
ajmsi-1760	156	4	,	,	PUNCT
ajmsi-1760	156	5	los	los	PROPN
ajmsi-1760	156	6	angeles	angeles	PROPN
ajmsi-1760	156	7	,	,	PUNCT
ajmsi-1760	156	8	california	california	PROPN
ajmsi-1760	156	9	,	,	PUNCT
ajmsi-1760	156	10	united	united	PROPN
ajmsi-1760	156	11	states	states	PROPN
ajmsi-1760	156	12	.	.	PUNCT
ajmsi-1760	157	1	2	2	X
ajmsi-1760	157	2	.	.	X
ajmsi-1760	157	3	ucsf	ucsf	PROPN
ajmsi-1760	157	4	benioff	benioff	PROPN
ajmsi-1760	157	5	children	children	PROPN
ajmsi-1760	157	6	’s	’s	PART
ajmsi-1760	157	7	hospital	hospital	NOUN
ajmsi-1760	157	8	,	,	PUNCT
ajmsi-1760	157	9	oakland	oakland	PROPN
ajmsi-1760	157	10	,	,	PUNCT
ajmsi-1760	157	11	california	california	PROPN
ajmsi-1760	157	12	,	,	PUNCT
ajmsi-1760	157	13	united	united	PROPN
ajmsi-1760	157	14	states	states	PROPN
ajmsi-1760	157	15	.	.	PUNCT
ajmsi-1760	158	1	5	5	NUM
ajmsi-1760	158	2	gene	gene	NOUN
ajmsi-1760	158	3	correction	correction	NOUN
ajmsi-1760	158	4	in	in	ADP
ajmsi-1760	158	5	autologous	autologous	ADJ
ajmsi-1760	158	6	cd34	cd34	PROPN
ajmsi-1760	158	7	+	+	ADJ
ajmsi-1760	158	8	hematopoietic	hematopoietic	ADJ
ajmsi-1760	158	9	stem	stem	NOUN
ajmsi-1760	158	10	cells	cell	NOUN
ajmsi-1760	158	11	(	(	PUNCT
ajmsi-1760	158	12	hbs	hbs	PROPN
ajmsi-1760	158	13	to	to	PART
ajmsi-1760	158	14	hba	hba	VERB
ajmsi-1760	158	15	)	)	PUNCT
ajmsi-1760	158	16	to	to	PART
ajmsi-1760	158	17	treat	treat	VERB
ajmsi-1760	158	18	severe	severe	ADJ
ajmsi-1760	158	19	scd	scd	PROPN
ajmsi-1760	158	20	•	•	PROPN
ajmsi-1760	158	21	scd	scd	PROPN
ajmsi-1760	158	22	•	•	NOUN
ajmsi-1760	158	23	genetic	genetic	ADJ
ajmsi-1760	158	24	:	:	PUNCT
ajmsi-1760	158	25	gph101	gph101	NOUN
ajmsi-1760	158	26	drug	drug	NOUN
ajmsi-1760	158	27	product	product	NOUN
ajmsi-1760	158	28	•	•	NOUN
ajmsi-1760	158	29	phase	phase	NOUN
ajmsi-1760	158	30	1/2	1/2	NUM
ajmsi-1760	158	31	•	•	NOUN
ajmsi-1760	158	32	15	15	NUM
ajmsi-1760	158	33	estimated	estimate	VERB
ajmsi-1760	158	34	participants	participant	NOUN
ajmsi-1760	158	35	1.university	1.university	NUM
ajmsi-1760	158	36	of	of	ADP
ajmsi-1760	158	37	alabama	alabama	PROPN
ajmsi-1760	158	38	,	,	PUNCT
ajmsi-1760	158	39	birmingham	birmingham	PROPN
ajmsi-1760	158	40	,	,	PUNCT
ajmsi-1760	158	41	alabama	alabama	PROPN
ajmsi-1760	158	42	,	,	PUNCT
ajmsi-1760	158	43	united	united	PROPN
ajmsi-1760	158	44	states	states	PROPN
ajmsi-1760	158	45	.	.	PUNCT
ajmsi-1760	159	1	2	2	X
ajmsi-1760	159	2	.	.	X
ajmsi-1760	159	3	lucile	lucile	PROPN
ajmsi-1760	159	4	packard	packard	PROPN
ajmsi-1760	159	5	children	children	PROPN
ajmsi-1760	159	6	’s	’s	PART
ajmsi-1760	159	7	hospital	hospital	NOUN
ajmsi-1760	159	8	,	,	PUNCT
ajmsi-1760	159	9	palo	palo	PROPN
ajmsi-1760	159	10	alto	alto	PROPN
ajmsi-1760	159	11	,	,	PUNCT
ajmsi-1760	159	12	california	california	PROPN
ajmsi-1760	159	13	,	,	PUNCT
ajmsi-1760	159	14	united	united	PROPN
ajmsi-1760	159	15	states	states	PROPN
ajmsi-1760	159	16	.	.	PUNCT
ajmsi-1760	160	1	3.washington	3.washington	NUM
ajmsi-1760	160	2	university	university	NOUN
ajmsi-1760	160	3	,	,	PUNCT
ajmsi-1760	160	4	saint	saint	PROPN
ajmsi-1760	160	5	louis	louis	PROPN
ajmsi-1760	160	6	,	,	PUNCT
ajmsi-1760	160	7	missouri	missouri	PROPN
ajmsi-1760	160	8	,	,	PUNCT
ajmsi-1760	160	9	united	united	PROPN
ajmsi-1760	160	10	states	states	PROPN
ajmsi-1760	160	11	.	.	PUNCT
ajmsi-1760	161	1	6	6	NUM
ajmsi-1760	161	2	a	a	DET
ajmsi-1760	161	3	long	long	ADJ
ajmsi-1760	161	4	-	-	PUNCT
ajmsi-1760	161	5	term	term	NOUN
ajmsi-1760	161	6	follow	follow	NOUN
ajmsi-1760	161	7	-	-	PUNCT
ajmsi-1760	161	8	up	up	ADP
ajmsi-1760	161	9	study	study	NOUN
ajmsi-1760	161	10	in	in	ADP
ajmsi-1760	161	11	patients	patient	NOUN
ajmsi-1760	161	12	who	who	PRON
ajmsi-1760	161	13	received	receive	VERB
ajmsi-1760	161	14	ctx001	ctx001	PROPN
ajmsi-1760	161	15	•	•	NOUN
ajmsi-1760	161	16	β	β	X
ajmsi-1760	161	17	-	-	NOUN
ajmsi-1760	161	18	thalassemia	thalassemia	NOUN
ajmsi-1760	161	19	•	•	NUM
ajmsi-1760	161	20	thalassemia	thalassemia	NOUN
ajmsi-1760	161	21	•	•	NUM
ajmsi-1760	161	22	scd	scd	PROPN
ajmsi-1760	161	23	•	•	NOUN
ajmsi-1760	161	24	biological	biological	NOUN
ajmsi-1760	161	25	:	:	PUNCT
ajmsi-1760	161	26	ctx001	ctx001	ADJ
ajmsi-1760	161	27	•	•	NUM
ajmsi-1760	161	28	cohort	cohort	NOUN
ajmsi-1760	161	29	study	study	NOUN
ajmsi-1760	161	30	•	•	NOUN
ajmsi-1760	161	31	114	114	NUM
ajmsi-1760	161	32	estimated	estimate	VERB
ajmsi-1760	161	33	participants	participant	NOUN
ajmsi-1760	161	34	1	1	NUM
ajmsi-1760	161	35	.	.	PUNCT
ajmsi-1760	162	1	columbia	columbia	PROPN
ajmsi-1760	162	2	university	university	PROPN
ajmsi-1760	162	3	medical	medical	ADJ
ajmsi-1760	162	4	center	center	NOUN
ajmsi-1760	162	5	(	(	PUNCT
ajmsi-1760	162	6	21	21	NUM
ajmsi-1760	162	7	+	+	NUM
ajmsi-1760	162	8	years	year	NOUN
ajmsi-1760	162	9	)	)	PUNCT
ajmsi-1760	162	10	,	,	PUNCT
ajmsi-1760	162	11	new	new	PROPN
ajmsi-1760	162	12	york	york	PROPN
ajmsi-1760	162	13	,	,	PUNCT
ajmsi-1760	162	14	united	united	PROPN
ajmsi-1760	162	15	states	states	PROPN
ajmsi-1760	162	16	.	.	PUNCT
ajmsi-1760	163	1	2	2	X
ajmsi-1760	163	2	.	.	X
ajmsi-1760	163	3	columbia	columbia	PROPN
ajmsi-1760	163	4	university	university	PROPN
ajmsi-1760	163	5	medical	medical	ADJ
ajmsi-1760	163	6	center	center	NOUN
ajmsi-1760	163	7	,	,	PUNCT
ajmsi-1760	163	8	new	new	PROPN
ajmsi-1760	163	9	york	york	PROPN
ajmsi-1760	163	10	,	,	PUNCT
ajmsi-1760	163	11	united	united	PROPN
ajmsi-1760	163	12	states	states	PROPN
ajmsi-1760	163	13	.	.	PUNCT
ajmsi-1760	164	1	3	3	X
ajmsi-1760	164	2	.	.	X
ajmsi-1760	164	3	children	child	NOUN
ajmsi-1760	164	4	’s	’s	PART
ajmsi-1760	164	5	hospital	hospital	NOUN
ajmsi-1760	164	6	of	of	ADP
ajmsi-1760	164	7	philadelphia	philadelphia	PROPN
ajmsi-1760	164	8	,	,	PUNCT
ajmsi-1760	164	9	pennsylvania	pennsylvania	PROPN
ajmsi-1760	164	10	,	,	PUNCT
ajmsi-1760	164	11	united	united	PROPN
ajmsi-1760	164	12	states	states	PROPN
ajmsi-1760	164	13	.	.	PUNCT
ajmsi-1760	165	1	discussion	discussion	NOUN
ajmsi-1760	165	2	this	this	DET
ajmsi-1760	165	3	systematic	systematic	ADJ
ajmsi-1760	165	4	literature	literature	NOUN
ajmsi-1760	165	5	review	review	NOUN
ajmsi-1760	165	6	provides	provide	VERB
ajmsi-1760	165	7	an	an	DET
ajmsi-1760	165	8	overview	overview	NOUN
ajmsi-1760	165	9	of	of	ADP
ajmsi-1760	165	10	crispr	crispr	ADJ
ajmsi-1760	165	11	-	-	PUNCT
ajmsi-1760	165	12	cas9	cas9	NOUN
ajmsi-1760	165	13	genomic	genomic	NOUN
ajmsi-1760	165	14	editing	editing	NOUN
ajmsi-1760	165	15	and	and	CCONJ
ajmsi-1760	165	16	its	its	PRON
ajmsi-1760	165	17	application	application	NOUN
ajmsi-1760	165	18	to	to	PART
ajmsi-1760	165	19	sickle	sickle	VERB
ajmsi-1760	165	20	cell	cell	NOUN
ajmsi-1760	165	21	disease	disease	NOUN
ajmsi-1760	165	22	(	(	PUNCT
ajmsi-1760	165	23	scd	scd	NOUN
ajmsi-1760	165	24	)	)	PUNCT
ajmsi-1760	165	25	,	,	PUNCT
ajmsi-1760	165	26	while	while	SCONJ
ajmsi-1760	165	27	also	also	ADV
ajmsi-1760	165	28	addressing	address	VERB
ajmsi-1760	165	29	the	the	DET
ajmsi-1760	165	30	ethical	ethical	ADJ
ajmsi-1760	165	31	implications	implication	NOUN
ajmsi-1760	165	32	associated	associate	VERB
ajmsi-1760	165	33	with	with	ADP
ajmsi-1760	165	34	this	this	DET
ajmsi-1760	165	35	technology	technology	NOUN
ajmsi-1760	165	36	in	in	ADP
ajmsi-1760	165	37	scd	scd	PROPN
ajmsi-1760	165	38	management	management	NOUN
ajmsi-1760	165	39	.	.	PUNCT
ajmsi-1760	166	1	despite	despite	SCONJ
ajmsi-1760	166	2	the	the	DET
ajmsi-1760	166	3	wide	wide	ADJ
ajmsi-1760	166	4	use	use	NOUN
ajmsi-1760	166	5	of	of	ADP
ajmsi-1760	166	6	crispr	crispr	NOUN
ajmsi-1760	166	7	-	-	PUNCT
ajmsi-1760	166	8	cas9	cas9	NOUN
ajmsi-1760	166	9	as	as	ADP
ajmsi-1760	166	10	a	a	DET
ajmsi-1760	166	11	mature	mature	ADJ
ajmsi-1760	166	12	genomic	genomic	NOUN
ajmsi-1760	166	13	editing	edit	VERB
ajmsi-1760	166	14	tool	tool	NOUN
ajmsi-1760	166	15	,	,	PUNCT
ajmsi-1760	166	16	therapeutic	therapeutic	ADJ
ajmsi-1760	166	17	applications	application	NOUN
ajmsi-1760	166	18	still	still	ADV
ajmsi-1760	166	19	face	face	VERB
ajmsi-1760	166	20	challenges	challenge	NOUN
ajmsi-1760	166	21	such	such	ADJ
ajmsi-1760	166	22	as	as	ADP
ajmsi-1760	166	23	off	off	ADP
ajmsi-1760	166	24	-	-	PUNCT
ajmsi-1760	166	25	target	target	NOUN
ajmsi-1760	166	26	effects	effect	NOUN
ajmsi-1760	166	27	,	,	PUNCT
ajmsi-1760	166	28	complex	complex	ADJ
ajmsi-1760	166	29	in	in	ADP
ajmsi-1760	166	30	vivo	vivo	ADJ
ajmsi-1760	166	31	cas9	cas9	NOUN
ajmsi-1760	166	32	protein	protein	NOUN
ajmsi-1760	166	33	delivery	delivery	NOUN
ajmsi-1760	166	34	,	,	PUNCT
ajmsi-1760	166	35	low	low	ADJ
ajmsi-1760	166	36	gene	gene	NOUN
ajmsi-1760	166	37	editing	edit	VERB
ajmsi-1760	166	38	efficiency	efficiency	NOUN
ajmsi-1760	166	39	,	,	PUNCT
ajmsi-1760	166	40	and	and	CCONJ
ajmsi-1760	166	41	packaging	packaging	NOUN
ajmsi-1760	166	42	issues	issue	NOUN
ajmsi-1760	166	43	.	.	PUNCT
ajmsi-1760	167	1	to	to	PART
ajmsi-1760	167	2	become	become	VERB
ajmsi-1760	167	3	an	an	DET
ajmsi-1760	167	4	ideal	ideal	ADJ
ajmsi-1760	167	5	delivery	delivery	NOUN
ajmsi-1760	167	6	method	method	NOUN
ajmsi-1760	167	7	for	for	ADP
ajmsi-1760	167	8	therapeutics	therapeutic	NOUN
ajmsi-1760	167	9	,	,	PUNCT
ajmsi-1760	167	10	crispr	crispr	NOUN
ajmsi-1760	167	11	-	-	PUNCT
ajmsi-1760	167	12	cas9	cas9	NOUN
ajmsi-1760	167	13	strategies	strategy	NOUN
ajmsi-1760	167	14	should	should	AUX
ajmsi-1760	167	15	exhibit	exhibit	VERB
ajmsi-1760	167	16	high	high	ADJ
ajmsi-1760	167	17	delivery	delivery	NOUN
ajmsi-1760	167	18	efficiency	efficiency	NOUN
ajmsi-1760	167	19	,	,	PUNCT
ajmsi-1760	167	20	precise	precise	ADJ
ajmsi-1760	167	21	targeting	targeting	NOUN
ajmsi-1760	167	22	ability	ability	NOUN
ajmsi-1760	167	23	,	,	PUNCT
ajmsi-1760	167	24	and	and	CCONJ
ajmsi-1760	167	25	ease	ease	NOUN
ajmsi-1760	167	26	of	of	ADP
ajmsi-1760	167	27	mass	mass	ADJ
ajmsi-1760	167	28	production	production	NOUN
ajmsi-1760	167	29	.	.	PUNCT
ajmsi-1760	168	1	however	however	ADV
ajmsi-1760	168	2	,	,	PUNCT
ajmsi-1760	168	3	current	current	ADJ
ajmsi-1760	168	4	approaches	approach	NOUN
ajmsi-1760	168	5	in	in	ADP
ajmsi-1760	168	6	this	this	DET
ajmsi-1760	168	7	field	field	NOUN
ajmsi-1760	168	8	are	be	AUX
ajmsi-1760	168	9	far	far	ADV
ajmsi-1760	168	10	from	from	ADP
ajmsi-1760	168	11	achieving	achieve	VERB
ajmsi-1760	168	12	this	this	DET
ajmsi-1760	168	13	desired	desire	VERB
ajmsi-1760	168	14	level	level	NOUN
ajmsi-1760	168	15	of	of	ADP
ajmsi-1760	168	16	performance	performance	NOUN
ajmsi-1760	168	17	(	(	PUNCT
ajmsi-1760	168	18	guo	guo	PROPN
ajmsi-1760	168	19	,	,	PUNCT
ajmsi-1760	168	20	2022	2022	NUM
ajmsi-1760	168	21	)	)	PUNCT
ajmsi-1760	168	22	.	.	PUNCT
ajmsi-1760	169	1	while	while	SCONJ
ajmsi-1760	169	2	there	there	PRON
ajmsi-1760	169	3	is	be	VERB
ajmsi-1760	169	4	significant	significant	ADJ
ajmsi-1760	169	5	literature	literature	NOUN
ajmsi-1760	169	6	on	on	ADP
ajmsi-1760	169	7	why	why	SCONJ
ajmsi-1760	169	8	scd	scd	NOUN
ajmsi-1760	169	9	is	be	AUX
ajmsi-1760	169	10	a	a	DET
ajmsi-1760	169	11	suitable	suitable	ADJ
ajmsi-1760	169	12	candidate	candidate	NOUN
ajmsi-1760	169	13	for	for	ADP
ajmsi-1760	169	14	crispr	crispr	NOUN
ajmsi-1760	169	15	-	-	PUNCT
ajmsi-1760	169	16	cas9	cas9	NOUN
ajmsi-1760	169	17	,	,	PUNCT
ajmsi-1760	169	18	less	less	ADJ
ajmsi-1760	169	19	attention	attention	NOUN
ajmsi-1760	169	20	has	have	AUX
ajmsi-1760	169	21	been	be	AUX
ajmsi-1760	169	22	given	give	VERB
ajmsi-1760	169	23	to	to	ADP
ajmsi-1760	169	24	the	the	DET
ajmsi-1760	169	25	ethical	ethical	ADJ
ajmsi-1760	169	26	implications	implication	NOUN
ajmsi-1760	169	27	of	of	ADP
ajmsi-1760	169	28	including	include	VERB
ajmsi-1760	169	29	scd	scd	NOUN
ajmsi-1760	169	30	in	in	ADP
ajmsi-1760	169	31	crispr	crispr	ADJ
ajmsi-1760	169	32	-	-	PUNCT
ajmsi-1760	169	33	cas9	cas9	NOUN
ajmsi-1760	169	34	research	research	NOUN
ajmsi-1760	169	35	.	.	PUNCT
ajmsi-1760	170	1	in	in	ADP
ajmsi-1760	170	2	addition	addition	NOUN
ajmsi-1760	170	3	,	,	PUNCT
ajmsi-1760	170	4	the	the	DET
ajmsi-1760	170	5	implications	implication	NOUN
ajmsi-1760	170	6	of	of	ADP
ajmsi-1760	170	7	crispr	crispr	NOUN
ajmsi-1760	170	8	-	-	PUNCT
ajmsi-1760	170	9	cas9	cas9	NOUN
ajmsi-1760	170	10	for	for	ADP
ajmsi-1760	170	11	sickle	sickle	NOUN
ajmsi-1760	170	12	cell	cell	NOUN
ajmsi-1760	170	13	disease	disease	NOUN
ajmsi-1760	170	14	have	have	VERB
ajmsi-1760	170	15	significant	significant	ADJ
ajmsi-1760	170	16	consequences	consequence	NOUN
ajmsi-1760	170	17	for	for	ADP
ajmsi-1760	170	18	clinical	clinical	ADJ
ajmsi-1760	170	19	practice	practice	NOUN
ajmsi-1760	170	20	and	and	CCONJ
ajmsi-1760	170	21	policy	policy	NOUN
ajmsi-1760	170	22	.	.	PUNCT
ajmsi-1760	171	1	the	the	DET
ajmsi-1760	171	2	following	follow	VERB
ajmsi-1760	171	3	points	point	NOUN
ajmsi-1760	171	4	highlight	highlight	VERB
ajmsi-1760	171	5	some	some	PRON
ajmsi-1760	171	6	of	of	ADP
ajmsi-1760	171	7	the	the	DET
ajmsi-1760	171	8	potential	potential	ADJ
ajmsi-1760	171	9	implications	implication	NOUN
ajmsi-1760	171	10	:	:	PUNCT
ajmsi-1760	171	11	improved	improve	VERB
ajmsi-1760	171	12	outcomes	outcome	NOUN
ajmsi-1760	171	13	crispr	crispr	NOUN
ajmsi-1760	171	14	-	-	PUNCT
ajmsi-1760	171	15	cas9	cas9	NOUN
ajmsi-1760	171	16	holds	hold	VERB
ajmsi-1760	171	17	the	the	DET
ajmsi-1760	171	18	potential	potential	NOUN
ajmsi-1760	171	19	to	to	PART
ajmsi-1760	171	20	cure	cure	VERB
ajmsi-1760	171	21	scd	scd	NOUN
ajmsi-1760	171	22	by	by	ADP
ajmsi-1760	171	23	correcting	correct	VERB
ajmsi-1760	171	24	the	the	DET
ajmsi-1760	171	25	underlying	underlie	VERB
ajmsi-1760	171	26	genetic	genetic	ADJ
ajmsi-1760	171	27	mutation	mutation	NOUN
ajmsi-1760	171	28	.	.	PUNCT
ajmsi-1760	172	1	this	this	DET
ajmsi-1760	172	2	breakthrough	breakthrough	NOUN
ajmsi-1760	172	3	could	could	AUX
ajmsi-1760	172	4	lead	lead	VERB
ajmsi-1760	172	5	to	to	ADP
ajmsi-1760	172	6	improved	improved	ADJ
ajmsi-1760	172	7	outcomes	outcome	NOUN
ajmsi-1760	172	8	for	for	ADP
ajmsi-1760	172	9	patients	patient	NOUN
ajmsi-1760	172	10	,	,	PUNCT
ajmsi-1760	172	11	including	include	VERB
ajmsi-1760	172	12	reduced	reduce	VERB
ajmsi-1760	172	13	pain	pain	NOUN
ajmsi-1760	172	14	,	,	PUNCT
ajmsi-1760	172	15	enhanced	enhance	VERB
ajmsi-1760	172	16	quality	quality	NOUN
ajmsi-1760	172	17	of	of	ADP
ajmsi-1760	172	18	life	life	NOUN
ajmsi-1760	172	19	,	,	PUNCT
ajmsi-1760	172	20	and	and	CCONJ
ajmsi-1760	172	21	increased	increase	VERB
ajmsi-1760	172	22	lifespan	lifespan	NOUN
ajmsi-1760	172	23	.	.	PUNCT
ajmsi-1760	173	1	reduced	reduce	VERB
ajmsi-1760	173	2	healthcare	healthcare	PROPN
ajmsi-1760	173	3	costs	cost	NOUN
ajmsi-1760	173	4	scd	scd	PROPN
ajmsi-1760	173	5	treatment	treatment	NOUN
ajmsi-1760	173	6	can	can	AUX
ajmsi-1760	173	7	be	be	AUX
ajmsi-1760	173	8	expensive	expensive	ADJ
ajmsi-1760	173	9	,	,	PUNCT
ajmsi-1760	173	10	and	and	CCONJ
ajmsi-1760	173	11	the	the	DET
ajmsi-1760	173	12	use	use	NOUN
ajmsi-1760	173	13	of	of	ADP
ajmsi-1760	173	14	crisprpa	crisprpa	NOUN
ajmsi-1760	173	15	ge	ge	PROPN
ajmsi-1760	173	16	53	53	NUM
ajmsi-1760	173	17	https://journals.e-palli.com/home/index.php/ajmsi	https://journals.e-palli.com/home/index.php/ajmsi	PROPN
ajmsi-1760	173	18	am	be	AUX
ajmsi-1760	173	19	.	.	PUNCT
ajmsi-1760	174	1	j.	j.	PROPN
ajmsi-1760	174	2	med	med	PROPN
ajmsi-1760	174	3	.	.	PUNCT
ajmsi-1760	175	1	sci	sci	PROPN
ajmsi-1760	175	2	.	.	PUNCT
ajmsi-1760	175	3	innov	innov	PROPN
ajmsi-1760	175	4	.	.	PUNCT
ajmsi-1760	176	1	2(2	2(2	NUM
ajmsi-1760	176	2	)	)	PUNCT
ajmsi-1760	176	3	44	44	NUM
ajmsi-1760	176	4	-	-	SYM
ajmsi-1760	176	5	56	56	NUM
ajmsi-1760	176	6	,	,	PUNCT
ajmsi-1760	176	7	2023	2023	NUM
ajmsi-1760	176	8	cas9	cas9	NOUN
ajmsi-1760	176	9	may	may	AUX
ajmsi-1760	176	10	reduce	reduce	VERB
ajmsi-1760	176	11	healthcare	healthcare	NOUN
ajmsi-1760	176	12	costs	cost	NOUN
ajmsi-1760	176	13	by	by	ADP
ajmsi-1760	176	14	offering	offer	VERB
ajmsi-1760	176	15	a	a	DET
ajmsi-1760	176	16	curative	curative	ADJ
ajmsi-1760	176	17	approach	approach	NOUN
ajmsi-1760	176	18	rather	rather	ADV
ajmsi-1760	176	19	than	than	ADP
ajmsi-1760	176	20	merely	merely	ADV
ajmsi-1760	176	21	managing	manage	VERB
ajmsi-1760	176	22	symptoms	symptom	NOUN
ajmsi-1760	176	23	.	.	PUNCT
ajmsi-1760	177	1	ethical	ethical	ADJ
ajmsi-1760	177	2	considerations	consideration	NOUN
ajmsi-1760	177	3	the	the	DET
ajmsi-1760	177	4	use	use	NOUN
ajmsi-1760	177	5	of	of	ADP
ajmsi-1760	177	6	crispr	crispr	NOUN
ajmsi-1760	177	7	-	-	PUNCT
ajmsi-1760	177	8	cas9	cas9	NOUN
ajmsi-1760	177	9	in	in	ADP
ajmsi-1760	177	10	humans	human	NOUN
ajmsi-1760	177	11	raises	raise	VERB
ajmsi-1760	177	12	ethical	ethical	ADJ
ajmsi-1760	177	13	concerns	concern	NOUN
ajmsi-1760	177	14	regarding	regard	VERB
ajmsi-1760	177	15	safety	safety	NOUN
ajmsi-1760	177	16	and	and	CCONJ
ajmsi-1760	177	17	the	the	DET
ajmsi-1760	177	18	possibility	possibility	NOUN
ajmsi-1760	177	19	of	of	ADP
ajmsi-1760	177	20	unintended	unintended	ADJ
ajmsi-1760	177	21	consequences	consequence	NOUN
ajmsi-1760	177	22	.	.	PUNCT
ajmsi-1760	178	1	the	the	DET
ajmsi-1760	178	2	development	development	NOUN
ajmsi-1760	178	3	of	of	ADP
ajmsi-1760	178	4	policies	policy	NOUN
ajmsi-1760	178	5	is	be	AUX
ajmsi-1760	178	6	necessary	necessary	ADJ
ajmsi-1760	178	7	to	to	PART
ajmsi-1760	178	8	ensure	ensure	VERB
ajmsi-1760	178	9	the	the	DET
ajmsi-1760	178	10	ethical	ethical	ADJ
ajmsi-1760	178	11	and	and	CCONJ
ajmsi-1760	178	12	reliable	reliable	ADJ
ajmsi-1760	178	13	application	application	NOUN
ajmsi-1760	178	14	of	of	ADP
ajmsi-1760	178	15	crisprcas9	crisprcas9	NOUN
ajmsi-1760	178	16	.	.	PUNCT
ajmsi-1760	179	1	access	access	NOUN
ajmsi-1760	179	2	to	to	ADP
ajmsi-1760	179	3	treatment	treatment	NOUN
ajmsi-1760	179	4	issues	issue	NOUN
ajmsi-1760	179	5	related	relate	VERB
ajmsi-1760	179	6	to	to	ADP
ajmsi-1760	179	7	access	access	NOUN
ajmsi-1760	179	8	to	to	ADP
ajmsi-1760	179	9	crispr	crispr	ADJ
ajmsi-1760	179	10	-	-	PUNCT
ajmsi-1760	179	11	cas9	cas9	NOUN
ajmsi-1760	179	12	treatment	treatment	NOUN
ajmsi-1760	179	13	for	for	ADP
ajmsi-1760	179	14	scd	scd	NOUN
ajmsi-1760	179	15	patients	patient	NOUN
ajmsi-1760	179	16	may	may	AUX
ajmsi-1760	179	17	arise	arise	VERB
ajmsi-1760	179	18	,	,	PUNCT
ajmsi-1760	179	19	particularly	particularly	ADV
ajmsi-1760	179	20	in	in	ADP
ajmsi-1760	179	21	lowand	lowand	ADJ
ajmsi-1760	179	22	middleincome	middleincome	PROPN
ajmsi-1760	179	23	countries	country	NOUN
ajmsi-1760	179	24	.	.	PUNCT
ajmsi-1760	180	1	policies	policy	NOUN
ajmsi-1760	180	2	should	should	AUX
ajmsi-1760	180	3	be	be	AUX
ajmsi-1760	180	4	developed	develop	VERB
ajmsi-1760	180	5	to	to	PART
ajmsi-1760	180	6	ensure	ensure	VERB
ajmsi-1760	180	7	equitable	equitable	ADJ
ajmsi-1760	180	8	access	access	NOUN
ajmsi-1760	180	9	to	to	ADP
ajmsi-1760	180	10	the	the	DET
ajmsi-1760	180	11	benefits	benefit	NOUN
ajmsi-1760	180	12	of	of	ADP
ajmsi-1760	180	13	this	this	DET
ajmsi-1760	180	14	technology	technology	NOUN
ajmsi-1760	180	15	for	for	ADP
ajmsi-1760	180	16	all	all	DET
ajmsi-1760	180	17	patients	patient	NOUN
ajmsi-1760	180	18	in	in	ADP
ajmsi-1760	180	19	need	need	NOUN
ajmsi-1760	180	20	.	.	PUNCT
ajmsi-1760	181	1	conclusion	conclusion	NOUN
ajmsi-1760	181	2	after	after	ADP
ajmsi-1760	181	3	analyzing	analyze	VERB
ajmsi-1760	181	4	the	the	DET
ajmsi-1760	181	5	available	available	ADJ
ajmsi-1760	181	6	evidence	evidence	NOUN
ajmsi-1760	181	7	on	on	ADP
ajmsi-1760	181	8	the	the	DET
ajmsi-1760	181	9	use	use	NOUN
ajmsi-1760	181	10	of	of	ADP
ajmsi-1760	181	11	crispr	crispr	NOUN
ajmsi-1760	181	12	-	-	PUNCT
ajmsi-1760	181	13	cas9	cas9	NOUN
ajmsi-1760	181	14	for	for	ADP
ajmsi-1760	181	15	the	the	DET
ajmsi-1760	181	16	management	management	NOUN
ajmsi-1760	181	17	of	of	ADP
ajmsi-1760	181	18	scd	scd	PROPN
ajmsi-1760	181	19	,	,	PUNCT
ajmsi-1760	181	20	it	it	PRON
ajmsi-1760	181	21	can	can	AUX
ajmsi-1760	181	22	be	be	AUX
ajmsi-1760	181	23	concluded	conclude	VERB
ajmsi-1760	181	24	that	that	SCONJ
ajmsi-1760	181	25	this	this	DET
ajmsi-1760	181	26	technology	technology	NOUN
ajmsi-1760	181	27	is	be	AUX
ajmsi-1760	181	28	novel	novel	ADJ
ajmsi-1760	181	29	and	and	CCONJ
ajmsi-1760	181	30	shows	show	VERB
ajmsi-1760	181	31	promise	promise	NOUN
ajmsi-1760	181	32	as	as	ADP
ajmsi-1760	181	33	a	a	DET
ajmsi-1760	181	34	potential	potential	ADJ
ajmsi-1760	181	35	therapeutic	therapeutic	ADJ
ajmsi-1760	181	36	option	option	NOUN
ajmsi-1760	181	37	for	for	ADP
ajmsi-1760	181	38	the	the	DET
ajmsi-1760	181	39	condition	condition	NOUN
ajmsi-1760	181	40	.	.	PUNCT
ajmsi-1760	182	1	studies	study	NOUN
ajmsi-1760	182	2	have	have	AUX
ajmsi-1760	182	3	demonstrated	demonstrate	VERB
ajmsi-1760	182	4	the	the	DET
ajmsi-1760	182	5	successful	successful	ADJ
ajmsi-1760	182	6	correction	correction	NOUN
ajmsi-1760	182	7	of	of	ADP
ajmsi-1760	182	8	the	the	DET
ajmsi-1760	182	9	genetic	genetic	ADJ
ajmsi-1760	182	10	mutation	mutation	NOUN
ajmsi-1760	182	11	responsible	responsible	ADJ
ajmsi-1760	182	12	for	for	ADP
ajmsi-1760	182	13	scd	scd	NOUN
ajmsi-1760	182	14	in	in	ADP
ajmsi-1760	182	15	clinical	clinical	ADJ
ajmsi-1760	182	16	settings	setting	NOUN
ajmsi-1760	182	17	.	.	PUNCT
ajmsi-1760	183	1	one	one	NUM
ajmsi-1760	183	2	of	of	ADP
ajmsi-1760	183	3	the	the	DET
ajmsi-1760	183	4	main	main	ADJ
ajmsi-1760	183	5	challenges	challenge	NOUN
ajmsi-1760	183	6	of	of	ADP
ajmsi-1760	183	7	this	this	DET
ajmsi-1760	183	8	technology	technology	NOUN
ajmsi-1760	183	9	is	be	AUX
ajmsi-1760	183	10	the	the	DET
ajmsi-1760	183	11	delivery	delivery	NOUN
ajmsi-1760	183	12	of	of	ADP
ajmsi-1760	183	13	the	the	DET
ajmsi-1760	183	14	crispr	crispr	ADJ
ajmsi-1760	183	15	-	-	PUNCT
ajmsi-1760	183	16	cas9	cas9	NOUN
ajmsi-1760	183	17	system	system	NOUN
ajmsi-1760	183	18	to	to	ADP
ajmsi-1760	183	19	the	the	DET
ajmsi-1760	183	20	bone	bone	NOUN
ajmsi-1760	183	21	marrow	marrow	NOUN
ajmsi-1760	183	22	,	,	PUNCT
ajmsi-1760	183	23	where	where	SCONJ
ajmsi-1760	183	24	the	the	DET
ajmsi-1760	183	25	hematopoietic	hematopoietic	ADJ
ajmsi-1760	183	26	stem	stem	NOUN
ajmsi-1760	183	27	cells	cell	NOUN
ajmsi-1760	183	28	reside	reside	VERB
ajmsi-1760	183	29	.	.	PUNCT
ajmsi-1760	184	1	the	the	DET
ajmsi-1760	184	2	off	off	ADP
ajmsi-1760	184	3	-	-	PUNCT
ajmsi-1760	184	4	target	target	NOUN
ajmsi-1760	184	5	effects	effect	NOUN
ajmsi-1760	184	6	of	of	ADP
ajmsi-1760	184	7	the	the	DET
ajmsi-1760	184	8	crispr	crispr	ADJ
ajmsi-1760	184	9	-	-	PUNCT
ajmsi-1760	184	10	cas9	cas9	NOUN
ajmsi-1760	184	11	system	system	NOUN
ajmsi-1760	184	12	also	also	ADV
ajmsi-1760	184	13	need	need	VERB
ajmsi-1760	184	14	to	to	PART
ajmsi-1760	184	15	be	be	AUX
ajmsi-1760	184	16	further	far	ADV
ajmsi-1760	184	17	studied	study	VERB
ajmsi-1760	184	18	and	and	CCONJ
ajmsi-1760	184	19	minimized	minimize	VERB
ajmsi-1760	184	20	to	to	PART
ajmsi-1760	184	21	ensure	ensure	VERB
ajmsi-1760	184	22	the	the	DET
ajmsi-1760	184	23	safety	safety	NOUN
ajmsi-1760	184	24	of	of	ADP
ajmsi-1760	184	25	the	the	DET
ajmsi-1760	184	26	treatment	treatment	NOUN
ajmsi-1760	184	27	.	.	PUNCT
ajmsi-1760	185	1	despite	despite	SCONJ
ajmsi-1760	185	2	these	these	DET
ajmsi-1760	185	3	challenges	challenge	NOUN
ajmsi-1760	185	4	,	,	PUNCT
ajmsi-1760	185	5	the	the	DET
ajmsi-1760	185	6	potential	potential	ADJ
ajmsi-1760	185	7	benefits	benefit	NOUN
ajmsi-1760	185	8	of	of	ADP
ajmsi-1760	185	9	crispr	crispr	NOUN
ajmsi-1760	185	10	-	-	PUNCT
ajmsi-1760	185	11	cas9	cas9	NOUN
ajmsi-1760	185	12	for	for	ADP
ajmsi-1760	185	13	scd	scd	NOUN
ajmsi-1760	185	14	can	can	AUX
ajmsi-1760	185	15	not	not	PART
ajmsi-1760	185	16	be	be	AUX
ajmsi-1760	185	17	neglected	neglect	VERB
ajmsi-1760	185	18	.	.	PUNCT
ajmsi-1760	186	1	the	the	DET
ajmsi-1760	186	2	ability	ability	NOUN
ajmsi-1760	186	3	to	to	PART
ajmsi-1760	186	4	correct	correct	VERB
ajmsi-1760	186	5	the	the	DET
ajmsi-1760	186	6	genetic	genetic	ADJ
ajmsi-1760	186	7	mutation	mutation	NOUN
ajmsi-1760	186	8	responsible	responsible	ADJ
ajmsi-1760	186	9	for	for	ADP
ajmsi-1760	186	10	the	the	DET
ajmsi-1760	186	11	condition	condition	NOUN
ajmsi-1760	186	12	offers	offer	VERB
ajmsi-1760	186	13	a	a	DET
ajmsi-1760	186	14	potentially	potentially	ADV
ajmsi-1760	186	15	curative	curative	ADJ
ajmsi-1760	186	16	approach	approach	NOUN
ajmsi-1760	186	17	to	to	ADP
ajmsi-1760	186	18	the	the	DET
ajmsi-1760	186	19	disease	disease	NOUN
ajmsi-1760	186	20	.	.	PUNCT
ajmsi-1760	187	1	overall	overall	ADJ
ajmsi-1760	187	2	,	,	PUNCT
ajmsi-1760	187	3	further	further	ADJ
ajmsi-1760	187	4	research	research	NOUN
ajmsi-1760	187	5	and	and	CCONJ
ajmsi-1760	187	6	clinical	clinical	ADJ
ajmsi-1760	187	7	trials	trial	NOUN
ajmsi-1760	187	8	are	be	AUX
ajmsi-1760	187	9	necessary	necessary	ADJ
ajmsi-1760	187	10	to	to	PART
ajmsi-1760	187	11	fully	fully	ADV
ajmsi-1760	187	12	evaluate	evaluate	VERB
ajmsi-1760	187	13	the	the	DET
ajmsi-1760	187	14	safety	safety	NOUN
ajmsi-1760	187	15	and	and	CCONJ
ajmsi-1760	187	16	efficacy	efficacy	NOUN
ajmsi-1760	187	17	of	of	ADP
ajmsi-1760	187	18	crispr	crispr	NOUN
ajmsi-1760	187	19	-	-	PUNCT
ajmsi-1760	187	20	cas9	cas9	NOUN
ajmsi-1760	187	21	as	as	ADP
ajmsi-1760	187	22	a	a	DET
ajmsi-1760	187	23	therapeutic	therapeutic	ADJ
ajmsi-1760	187	24	option	option	NOUN
ajmsi-1760	187	25	for	for	ADP
ajmsi-1760	187	26	scd	scd	NOUN
ajmsi-1760	187	27	.	.	PUNCT
ajmsi-1760	188	1	nevertheless	nevertheless	ADV
ajmsi-1760	188	2	,	,	PUNCT
ajmsi-1760	188	3	the	the	DET
ajmsi-1760	188	4	current	current	ADJ
ajmsi-1760	188	5	evidence	evidence	NOUN
ajmsi-1760	188	6	suggests	suggest	VERB
ajmsi-1760	188	7	that	that	SCONJ
ajmsi-1760	188	8	crispr	crispr	NOUN
ajmsi-1760	188	9	-	-	PUNCT
ajmsi-1760	188	10	cas9	cas9	NOUN
ajmsi-1760	188	11	has	have	VERB
ajmsi-1760	188	12	the	the	DET
ajmsi-1760	188	13	potential	potential	NOUN
ajmsi-1760	188	14	to	to	PART
ajmsi-1760	188	15	revolutionize	revolutionize	VERB
ajmsi-1760	188	16	the	the	DET
ajmsi-1760	188	17	treatment	treatment	NOUN
ajmsi-1760	188	18	of	of	ADP
ajmsi-1760	188	19	this	this	DET
ajmsi-1760	188	20	debilitating	debilitate	VERB
ajmsi-1760	188	21	disease	disease	NOUN
ajmsi-1760	188	22	by	by	ADP
ajmsi-1760	188	23	offering	offer	VERB
ajmsi-1760	188	24	a	a	DET
ajmsi-1760	188	25	curative	curative	ADJ
ajmsi-1760	188	26	option	option	NOUN
ajmsi-1760	188	27	.	.	PUNCT
ajmsi-1760	189	1	conflict	conflict	NOUN
ajmsi-1760	189	2	of	of	ADP
ajmsi-1760	189	3	interest	interest	NOUN
ajmsi-1760	189	4	the	the	DET
ajmsi-1760	189	5	authors	author	NOUN
ajmsi-1760	189	6	hereby	hereby	ADV
ajmsi-1760	189	7	declare	declare	VERB
ajmsi-1760	189	8	no	no	DET
ajmsi-1760	189	9	conflict	conflict	NOUN
ajmsi-1760	189	10	of	of	ADP
ajmsi-1760	189	11	interest	interest	NOUN
ajmsi-1760	189	12	in	in	ADP
ajmsi-1760	189	13	conducting	conduct	VERB
ajmsi-1760	189	14	this	this	DET
ajmsi-1760	189	15	research	research	NOUN
ajmsi-1760	189	16	,	,	PUNCT
ajmsi-1760	189	17	and	and	CCONJ
ajmsi-1760	189	18	in	in	ADP
ajmsi-1760	189	19	publishing	publish	VERB
ajmsi-1760	189	20	this	this	DET
ajmsi-1760	189	21	manuscript	manuscript	NOUN
ajmsi-1760	189	22	.	.	PUNCT
ajmsi-1760	190	1	references	reference	NOUN
ajmsi-1760	190	2	adams	adams	PROPN
ajmsi-1760	190	3	,	,	PUNCT
ajmsi-1760	190	4	r.	r.	PROPN
ajmsi-1760	190	5	j.	j.	PROPN
ajmsi-1760	190	6	,	,	PUNCT
ajmsi-1760	190	7	mckie	mckie	PROPN
ajmsi-1760	190	8	,	,	PUNCT
ajmsi-1760	190	9	v.	v.	PROPN
ajmsi-1760	190	10	c.	c.	PROPN
ajmsi-1760	190	11	,	,	PUNCT
ajmsi-1760	190	12	hsu	hsu	PROPN
ajmsi-1760	190	13	,	,	PUNCT
ajmsi-1760	190	14	l.	l.	PROPN
ajmsi-1760	190	15	,	,	PUNCT
ajmsi-1760	190	16	files	file	NOUN
ajmsi-1760	190	17	,	,	PUNCT
ajmsi-1760	190	18	b.	b.	PROPN
ajmsi-1760	190	19	,	,	PUNCT
ajmsi-1760	190	20	vichinsky	vichinsky	PROPN
ajmsi-1760	190	21	,	,	PUNCT
ajmsi-1760	190	22	e.	e.	PROPN
ajmsi-1760	190	23	,	,	PUNCT
ajmsi-1760	190	24	pegelow	pegelow	NOUN
ajmsi-1760	190	25	,	,	PUNCT
ajmsi-1760	190	26	c.	c.	PROPN
ajmsi-1760	190	27	&	&	CCONJ
ajmsi-1760	190	28	et	et	PROPN
ajmsi-1760	190	29	al	al	PROPN
ajmsi-1760	190	30	.	.	PROPN
ajmsi-1760	190	31	(	(	PUNCT
ajmsi-1760	190	32	1998	1998	NUM
ajmsi-1760	190	33	)	)	PUNCT
ajmsi-1760	190	34	.	.	PUNCT
ajmsi-1760	191	1	prevention	prevention	NOUN
ajmsi-1760	191	2	of	of	ADP
ajmsi-1760	191	3	a	a	DET
ajmsi-1760	191	4	first	first	ADJ
ajmsi-1760	191	5	stroke	stroke	NOUN
ajmsi-1760	191	6	by	by	ADP
ajmsi-1760	191	7	transfusions	transfusion	NOUN
ajmsi-1760	191	8	in	in	ADP
ajmsi-1760	191	9	children	child	NOUN
ajmsi-1760	191	10	with	with	ADP
ajmsi-1760	191	11	sickle	sickle	NOUN
ajmsi-1760	191	12	cell	cell	NOUN
ajmsi-1760	191	13	anaemia	anaemia	NOUN
ajmsi-1760	191	14	and	and	CCONJ
ajmsi-1760	191	15	abnormal	abnormal	ADJ
ajmsi-1760	191	16	results	result	NOUN
ajmsi-1760	191	17	on	on	ADP
ajmsi-1760	191	18	transcranial	transcranial	ADJ
ajmsi-1760	191	19	doppler	doppler	NOUN
ajmsi-1760	191	20	ultrasonography	ultrasonography	NOUN
ajmsi-1760	191	21	.	.	PUNCT
ajmsi-1760	192	1	the	the	DET
ajmsi-1760	192	2	new	new	PROPN
ajmsi-1760	192	3	england	england	PROPN
ajmsi-1760	192	4	journal	journal	PROPN
ajmsi-1760	192	5	of	of	ADP
ajmsi-1760	192	6	medicine	medicine	NOUN
ajmsi-1760	192	7	,	,	PUNCT
ajmsi-1760	192	8	339(1	339(1	NUM
ajmsi-1760	192	9	)	)	PUNCT
ajmsi-1760	192	10	,	,	PUNCT
ajmsi-1760	192	11	5	5	NUM
ajmsi-1760	192	12	-	-	SYM
ajmsi-1760	192	13	11	11	NUM
ajmsi-1760	192	14	.	.	PUNCT
ajmsi-1760	193	1	https://doi.org/10.1056/	https://doi.org/10.1056/	NOUN
ajmsi-1760	193	2	nejm199807023390102	nejm199807023390102	PROPN
ajmsi-1760	193	3	.	.	PUNCT
ajmsi-1760	194	1	ataga	ataga	NOUN
ajmsi-1760	194	2	,	,	PUNCT
ajmsi-1760	194	3	k.	k.	PROPN
ajmsi-1760	194	4	i.	i.	PROPN
ajmsi-1760	194	5	,	,	PUNCT
ajmsi-1760	194	6	kutlar	kutlar	PROPN
ajmsi-1760	194	7	,	,	PUNCT
ajmsi-1760	194	8	a.	a.	PROPN
ajmsi-1760	194	9	,	,	PUNCT
ajmsi-1760	194	10	kanter	kanter	PROPN
ajmsi-1760	194	11	,	,	PUNCT
ajmsi-1760	194	12	j.	j.	PROPN
ajmsi-1760	194	13	,	,	PUNCT
ajmsi-1760	194	14	liles	liles	PROPN
ajmsi-1760	194	15	,	,	PUNCT
ajmsi-1760	194	16	d.	d.	PROPN
ajmsi-1760	194	17	,	,	PUNCT
ajmsi-1760	194	18	cancado	cancado	PROPN
ajmsi-1760	194	19	,	,	PUNCT
ajmsi-1760	194	20	r.	r.	PROPN
ajmsi-1760	194	21	,	,	PUNCT
ajmsi-1760	194	22	friedrisch	friedrisch	PROPN
ajmsi-1760	194	23	,	,	PUNCT
ajmsi-1760	194	24	j.	j.	PROPN
ajmsi-1760	194	25	&	&	CCONJ
ajmsi-1760	194	26	et	et	PROPN
ajmsi-1760	194	27	al	al	PROPN
ajmsi-1760	194	28	.	.	PROPN
ajmsi-1760	195	1	(	(	PUNCT
ajmsi-1760	195	2	2017	2017	NUM
ajmsi-1760	195	3	)	)	PUNCT
ajmsi-1760	195	4	.	.	PUNCT
ajmsi-1760	196	1	crizanlizumab	crizanlizumab	NOUN
ajmsi-1760	196	2	for	for	ADP
ajmsi-1760	196	3	the	the	DET
ajmsi-1760	196	4	prevention	prevention	NOUN
ajmsi-1760	196	5	of	of	ADP
ajmsi-1760	196	6	pain	pain	NOUN
ajmsi-1760	196	7	crises	crisis	NOUN
ajmsi-1760	196	8	in	in	ADP
ajmsi-1760	196	9	sickle	sickle	NOUN
ajmsi-1760	196	10	cell	cell	NOUN
ajmsi-1760	196	11	disease	disease	NOUN
ajmsi-1760	196	12	.	.	PUNCT
ajmsi-1760	197	1	the	the	DET
ajmsi-1760	197	2	new	new	PROPN
ajmsi-1760	197	3	england	england	PROPN
ajmsi-1760	197	4	journal	journal	PROPN
ajmsi-1760	197	5	of	of	ADP
ajmsi-1760	197	6	medicine	medicine	NOUN
ajmsi-1760	197	7	,	,	PUNCT
ajmsi-1760	197	8	376	376	NUM
ajmsi-1760	197	9	,	,	PUNCT
ajmsi-1760	197	10	429	429	NUM
ajmsi-1760	197	11	-	-	SYM
ajmsi-1760	197	12	439	439	NUM
ajmsi-1760	197	13	.	.	PUNCT
ajmsi-1760	198	1	bak	bak	PROPN
ajmsi-1760	198	2	,	,	PUNCT
ajmsi-1760	198	3	r.	r.	PROPN
ajmsi-1760	198	4	o.	o.	PROPN
ajmsi-1760	198	5	,	,	PUNCT
ajmsi-1760	198	6	dever	dever	PROPN
ajmsi-1760	198	7	,	,	PUNCT
ajmsi-1760	198	8	d.	d.	PROPN
ajmsi-1760	198	9	p.	p.	PROPN
ajmsi-1760	198	10	&	&	CCONJ
ajmsi-1760	198	11	porteus	porteus	PROPN
ajmsi-1760	198	12	,	,	PUNCT
ajmsi-1760	198	13	m.	m.	NOUN
ajmsi-1760	198	14	h.	h.	PROPN
ajmsi-1760	198	15	(	(	PUNCT
ajmsi-1760	198	16	2018	2018	NUM
ajmsi-1760	198	17	)	)	PUNCT
ajmsi-1760	198	18	.	.	PUNCT
ajmsi-1760	199	1	crisprcas9	crisprcas9	NOUN
ajmsi-1760	199	2	genome	genome	NOUN
ajmsi-1760	199	3	editing	editing	NOUN
ajmsi-1760	199	4	in	in	ADP
ajmsi-1760	199	5	human	human	ADJ
ajmsi-1760	199	6	hematopoietic	hematopoietic	ADJ
ajmsi-1760	199	7	stem	stem	NOUN
ajmsi-1760	199	8	cells	cell	NOUN
ajmsi-1760	199	9	.	.	PUNCT
ajmsi-1760	200	1	nature	nature	NOUN
ajmsi-1760	200	2	protocols	protocol	NOUN
ajmsi-1760	200	3	,	,	PUNCT
ajmsi-1760	200	4	13(2	13(2	PROPN
ajmsi-1760	200	5	)	)	PUNCT
ajmsi-1760	200	6	,	,	PUNCT
ajmsi-1760	200	7	358–376	358–376	NUM
ajmsi-1760	200	8	.	.	PUNCT
ajmsi-1760	200	9	baronciani	baronciani	PROPN
ajmsi-1760	200	10	,	,	PUNCT
ajmsi-1760	200	11	d.	d.	PROPN
ajmsi-1760	200	12	,	,	PUNCT
ajmsi-1760	200	13	angelucci	angelucci	PROPN
ajmsi-1760	200	14	,	,	PUNCT
ajmsi-1760	200	15	e.	e.	PROPN
ajmsi-1760	200	16	,	,	PUNCT
ajmsi-1760	200	17	potschger	potschger	NOUN
ajmsi-1760	200	18	,	,	PUNCT
ajmsi-1760	200	19	u.	u.	PROPN
ajmsi-1760	200	20	,	,	PUNCT
ajmsi-1760	200	21	gaziev	gaziev	PROPN
ajmsi-1760	200	22	,	,	PUNCT
ajmsi-1760	200	23	j.	j.	PROPN
ajmsi-1760	200	24	,	,	PUNCT
ajmsi-1760	200	25	yesilipek	yesilipek	PROPN
ajmsi-1760	200	26	,	,	PUNCT
ajmsi-1760	200	27	a.	a.	NOUN
ajmsi-1760	200	28	,	,	PUNCT
ajmsi-1760	200	29	zecca	zecca	NOUN
ajmsi-1760	200	30	,	,	PUNCT
ajmsi-1760	200	31	m.	m.	NOUN
ajmsi-1760	200	32	&	&	CCONJ
ajmsi-1760	200	33	et	et	PROPN
ajmsi-1760	200	34	al	al	PROPN
ajmsi-1760	200	35	.	.	PROPN
ajmsi-1760	201	1	(	(	PUNCT
ajmsi-1760	201	2	2016	2016	NUM
ajmsi-1760	201	3	)	)	PUNCT
ajmsi-1760	201	4	.	.	PUNCT
ajmsi-1760	202	1	haemopoietic	haemopoietic	ADJ
ajmsi-1760	202	2	stem	stem	NOUN
ajmsi-1760	202	3	cell	cell	NOUN
ajmsi-1760	202	4	transplantation	transplantation	NOUN
ajmsi-1760	202	5	in	in	ADP
ajmsi-1760	202	6	thalassemia	thalassemia	NOUN
ajmsi-1760	202	7	:	:	PUNCT
ajmsi-1760	202	8	a	a	DET
ajmsi-1760	202	9	report	report	NOUN
ajmsi-1760	202	10	from	from	ADP
ajmsi-1760	202	11	the	the	DET
ajmsi-1760	202	12	european	european	PROPN
ajmsi-1760	202	13	society	society	NOUN
ajmsi-1760	202	14	for	for	ADP
ajmsi-1760	202	15	blood	blood	NOUN
ajmsi-1760	202	16	and	and	CCONJ
ajmsi-1760	202	17	bone	bone	NOUN
ajmsi-1760	202	18	marrow	marrow	NOUN
ajmsi-1760	202	19	transplantation	transplantation	VERB
ajmsi-1760	202	20	haemoglobinopathy	haemoglobinopathy	ADJ
ajmsi-1760	202	21	registry	registry	NOUN
ajmsi-1760	202	22	,	,	PUNCT
ajmsi-1760	202	23	20002010	20002010	NUM
ajmsi-1760	202	24	.	.	PUNCT
ajmsi-1760	203	1	bone	bone	NOUN
ajmsi-1760	203	2	marrow	marrow	PROPN
ajmsi-1760	203	3	transplant	transplant	NOUN
ajmsi-1760	203	4	,	,	PUNCT
ajmsi-1760	203	5	51	51	NUM
ajmsi-1760	203	6	,	,	PUNCT
ajmsi-1760	203	7	536	536	NUM
ajmsi-1760	203	8	-	-	SYM
ajmsi-1760	203	9	541	541	NUM
ajmsi-1760	203	10	.	.	PUNCT
ajmsi-1760	204	1	canver	canver	PROPN
ajmsi-1760	204	2	,	,	PUNCT
ajmsi-1760	204	3	m.	m.	PROPN
ajmsi-1760	204	4	c.	c.	PROPN
ajmsi-1760	204	5	,	,	PUNCT
ajmsi-1760	204	6	smith	smith	PROPN
ajmsi-1760	204	7	,	,	PUNCT
ajmsi-1760	204	8	e.	e.	PROPN
ajmsi-1760	204	9	c.	c.	PROPN
ajmsi-1760	204	10	,	,	PUNCT
ajmsi-1760	204	11	sher	sher	PROPN
ajmsi-1760	204	12	,	,	PUNCT
ajmsi-1760	204	13	f.	f.	PROPN
ajmsi-1760	204	14	,	,	PUNCT
ajmsi-1760	204	15	pinello	pinello	PROPN
ajmsi-1760	204	16	,	,	PUNCT
ajmsi-1760	204	17	l.	l.	PROPN
ajmsi-1760	204	18	,	,	PUNCT
ajmsi-1760	204	19	sanjana	sanjana	PROPN
ajmsi-1760	204	20	,	,	PUNCT
ajmsi-1760	204	21	n.	n.	PROPN
ajmsi-1760	204	22	e.	e.	PROPN
ajmsi-1760	204	23	,	,	PUNCT
ajmsi-1760	204	24	shalem	shalem	PROPN
ajmsi-1760	204	25	,	,	PUNCT
ajmsi-1760	204	26	o.	o.	PROPN
ajmsi-1760	204	27	&	&	CCONJ
ajmsi-1760	204	28	et	et	PROPN
ajmsi-1760	204	29	al	al	PROPN
ajmsi-1760	204	30	.	.	PROPN
ajmsi-1760	204	31	(	(	PUNCT
ajmsi-1760	204	32	2015	2015	NUM
ajmsi-1760	204	33	)	)	PUNCT
ajmsi-1760	204	34	.	.	PUNCT
ajmsi-1760	205	1	bcl11a	bcl11a	PROPN
ajmsi-1760	205	2	enhancer	enhancer	NOUN
ajmsi-1760	205	3	dissection	dissection	NOUN
ajmsi-1760	205	4	by	by	ADP
ajmsi-1760	205	5	cas9	cas9	NOUN
ajmsi-1760	205	6	-	-	PUNCT
ajmsi-1760	205	7	mediated	mediate	VERB
ajmsi-1760	205	8	in	in	ADP
ajmsi-1760	205	9	situ	situ	NOUN
ajmsi-1760	205	10	saturating	saturate	VERB
ajmsi-1760	205	11	mutagenesis	mutagenesis	NOUN
ajmsi-1760	205	12	.	.	PUNCT
ajmsi-1760	206	1	nature	nature	NOUN
ajmsi-1760	206	2	,	,	PUNCT
ajmsi-1760	206	3	527	527	NUM
ajmsi-1760	206	4	,	,	PUNCT
ajmsi-1760	206	5	192	192	NUM
ajmsi-1760	206	6	-	-	SYM
ajmsi-1760	206	7	197	197	NUM
ajmsi-1760	206	8	.	.	PUNCT
ajmsi-1760	207	1	https://doi	https://doi	PROPN
ajmsi-1760	207	2	.	.	PUNCT
ajmsi-1760	207	3	org/10.1038	org/10.1038	PROPN
ajmsi-1760	207	4	/	/	SYM
ajmsi-1760	207	5	nature15521	nature15521	PROPN
ajmsi-1760	207	6	.	.	PUNCT
ajmsi-1760	208	1	chaudhary	chaudhary	PROPN
ajmsi-1760	208	2	,	,	PUNCT
ajmsi-1760	208	3	a.	a.	PROPN
ajmsi-1760	208	4	,	,	PUNCT
ajmsi-1760	208	5	kumari	kumari	PROPN
ajmsi-1760	208	6	,	,	PUNCT
ajmsi-1760	208	7	b.	b.	PROPN
ajmsi-1760	208	8	,	,	PUNCT
ajmsi-1760	208	9	choudhury	choudhury	PROPN
ajmsi-1760	208	10	,	,	PUNCT
ajmsi-1760	208	11	m.	m.	NOUN
ajmsi-1760	208	12	,	,	PUNCT
ajmsi-1760	208	13	singh	singh	PROPN
ajmsi-1760	208	14	,	,	PUNCT
ajmsi-1760	208	15	s.	s.	PROPN
ajmsi-1760	208	16	&	&	CCONJ
ajmsi-1760	208	17	kaur	kaur	PROPN
ajmsi-1760	208	18	.	.	PUNCT
ajmsi-1760	209	1	r.	r.	PROPN
ajmsi-1760	209	2	(	(	PUNCT
ajmsi-1760	209	3	2020	2020	NUM
ajmsi-1760	209	4	)	)	PUNCT
ajmsi-1760	209	5	.	.	PUNCT
ajmsi-1760	210	1	a	a	DET
ajmsi-1760	210	2	review	review	NOUN
ajmsi-1760	210	3	of	of	ADP
ajmsi-1760	210	4	the	the	DET
ajmsi-1760	210	5	therapeutic	therapeutic	ADJ
ajmsi-1760	210	6	potential	potential	NOUN
ajmsi-1760	210	7	,	,	PUNCT
ajmsi-1760	210	8	prospects	prospect	NOUN
ajmsi-1760	210	9	,	,	PUNCT
ajmsi-1760	210	10	and	and	CCONJ
ajmsi-1760	210	11	challenges	challenge	NOUN
ajmsi-1760	210	12	of	of	ADP
ajmsi-1760	210	13	crispr	crispr	ADJ
ajmsi-1760	210	14	/	/	SYM
ajmsi-1760	210	15	cas9	cas9	NOUN
ajmsi-1760	210	16	genome	genome	NOUN
ajmsi-1760	210	17	editing	editing	NOUN
ajmsi-1760	210	18	in	in	ADP
ajmsi-1760	210	19	the	the	DET
ajmsi-1760	210	20	treatment	treatment	NOUN
ajmsi-1760	210	21	of	of	ADP
ajmsi-1760	210	22	sickle	sickle	NOUN
ajmsi-1760	210	23	cell	cell	NOUN
ajmsi-1760	210	24	disease	disease	NOUN
ajmsi-1760	210	25	(	(	PUNCT
ajmsi-1760	210	26	scd	scd	PROPN
ajmsi-1760	210	27	)	)	PUNCT
ajmsi-1760	210	28	.	.	PUNCT
ajmsi-1760	211	1	international	international	ADJ
ajmsi-1760	211	2	journal	journal	PROPN
ajmsi-1760	211	3	of	of	ADP
ajmsi-1760	211	4	scientific	scientific	ADJ
ajmsi-1760	211	5	and	and	CCONJ
ajmsi-1760	211	6	research	research	NOUN
ajmsi-1760	211	7	publications	publication	NOUN
ajmsi-1760	211	8	(	(	PUNCT
ajmsi-1760	211	9	ijsrp	ijsrp	PROPN
ajmsi-1760	211	10	)	)	PUNCT
ajmsi-1760	211	11	,	,	PUNCT
ajmsi-1760	211	12	11(1	11(1	NUM
ajmsi-1760	211	13	)	)	PUNCT
ajmsi-1760	211	14	,	,	PUNCT
ajmsi-1760	211	15	670	670	NUM
ajmsi-1760	211	16	-	-	SYM
ajmsi-1760	211	17	676	676	NUM
ajmsi-1760	211	18	.	.	PUNCT
ajmsi-1760	212	1	https://doi.org/10.29322/	https://doi.org/10.29322/	ADJ
ajmsi-1760	212	2	ijsrp.11.01.2021.p10983	ijsrp.11.01.2021.p10983	NOUN
ajmsi-1760	212	3	.	.	PUNCT
ajmsi-1760	213	1	demirci	demirci	PROPN
ajmsi-1760	213	2	,	,	PUNCT
ajmsi-1760	213	3	s.	s.	PROPN
ajmsi-1760	213	4	,	,	PUNCT
ajmsi-1760	213	5	leonard	leonard	PROPN
ajmsi-1760	213	6	,	,	PUNCT
ajmsi-1760	213	7	a.	a.	PROPN
ajmsi-1760	213	8	,	,	PUNCT
ajmsi-1760	213	9	essawi	essawi	VERB
ajmsi-1760	213	10	,	,	PUNCT
ajmsi-1760	213	11	k.	k.	PROPN
ajmsi-1760	213	12	&	&	CCONJ
ajmsi-1760	213	13	tisdale	tisdale	PROPN
ajmsi-1760	213	14	,	,	PUNCT
ajmsi-1760	213	15	j.	j.	PROPN
ajmsi-1760	213	16	f.	f.	PROPN
ajmsi-1760	213	17	(	(	PUNCT
ajmsi-1760	213	18	2021	2021	NUM
ajmsi-1760	213	19	)	)	PUNCT
ajmsi-1760	213	20	.	.	PUNCT
ajmsi-1760	214	1	crispr	crispr	NOUN
ajmsi-1760	214	2	-	-	PUNCT
ajmsi-1760	214	3	cas9	cas9	NOUN
ajmsi-1760	214	4	to	to	PART
ajmsi-1760	214	5	induce	induce	VERB
ajmsi-1760	214	6	fetal	fetal	ADJ
ajmsi-1760	214	7	hemoglobin	hemoglobin	NOUN
ajmsi-1760	214	8	for	for	ADP
ajmsi-1760	214	9	the	the	DET
ajmsi-1760	214	10	treatment	treatment	NOUN
ajmsi-1760	214	11	of	of	ADP
ajmsi-1760	214	12	sickle	sickle	NOUN
ajmsi-1760	214	13	cell	cell	NOUN
ajmsi-1760	214	14	disease	disease	NOUN
ajmsi-1760	214	15	.	.	PUNCT
ajmsi-1760	215	1	molecular	molecular	ADJ
ajmsi-1760	215	2	therapy	therapy	NOUN
ajmsi-1760	215	3	,	,	PUNCT
ajmsi-1760	215	4	methods	method	NOUN
ajmsi-1760	215	5	&	&	CCONJ
ajmsi-1760	215	6	clinical	clinical	ADJ
ajmsi-1760	215	7	development	development	NOUN
ajmsi-1760	215	8	,	,	PUNCT
ajmsi-1760	215	9	23	23	NUM
ajmsi-1760	215	10	,	,	PUNCT
ajmsi-1760	215	11	276–285	276–285	NUM
ajmsi-1760	215	12	.	.	PUNCT
ajmsi-1760	216	1	demirci	demirci	PROPN
ajmsi-1760	216	2	,	,	PUNCT
ajmsi-1760	216	3	s.	s.	PROPN
ajmsi-1760	216	4	,	,	PUNCT
ajmsi-1760	216	5	leonard	leonard	PROPN
ajmsi-1760	216	6	,	,	PUNCT
ajmsi-1760	216	7	a.	a.	PROPN
ajmsi-1760	216	8	,	,	PUNCT
ajmsi-1760	216	9	haro	haro	NOUN
ajmsi-1760	216	10	-	-	PUNCT
ajmsi-1760	216	11	mora	mora	PROPN
ajmsi-1760	216	12	,	,	PUNCT
ajmsi-1760	216	13	j.	j.	PROPN
ajmsi-1760	216	14	j.	j.	PROPN
ajmsi-1760	216	15	,	,	PUNCT
ajmsi-1760	216	16	uchida	uchida	PROPN
ajmsi-1760	216	17	,	,	PUNCT
ajmsi-1760	216	18	n.	n.	PROPN
ajmsi-1760	216	19	&	&	CCONJ
ajmsi-1760	216	20	tisdale	tisdale	PROPN
ajmsi-1760	216	21	,	,	PUNCT
ajmsi-1760	216	22	j.	j.	PROPN
ajmsi-1760	216	23	f.	f.	PROPN
ajmsi-1760	216	24	(	(	PUNCT
ajmsi-1760	216	25	2019	2019	NUM
ajmsi-1760	216	26	)	)	PUNCT
ajmsi-1760	216	27	.	.	PUNCT
ajmsi-1760	217	1	crispr	crispr	PROPN
ajmsi-1760	217	2	/	/	SYM
ajmsi-1760	217	3	cas9	cas9	NOUN
ajmsi-1760	217	4	for	for	ADP
ajmsi-1760	217	5	sickle	sickle	NOUN
ajmsi-1760	217	6	cell	cell	NOUN
ajmsi-1760	217	7	disease	disease	NOUN
ajmsi-1760	217	8	:	:	PUNCT
ajmsi-1760	217	9	applications	application	NOUN
ajmsi-1760	217	10	,	,	PUNCT
ajmsi-1760	217	11	future	future	ADJ
ajmsi-1760	217	12	possibilities	possibility	NOUN
ajmsi-1760	217	13	,	,	PUNCT
ajmsi-1760	217	14	and	and	CCONJ
ajmsi-1760	217	15	challenges	challenge	NOUN
ajmsi-1760	217	16	.	.	PUNCT
ajmsi-1760	218	1	advances	advance	NOUN
ajmsi-1760	218	2	in	in	ADP
ajmsi-1760	218	3	experimental	experimental	ADJ
ajmsi-1760	218	4	medicine	medicine	NOUN
ajmsi-1760	218	5	and	and	CCONJ
ajmsi-1760	218	6	biology	biology	NOUN
ajmsi-1760	218	7	,	,	PUNCT
ajmsi-1760	218	8	1144	1144	NUM
ajmsi-1760	218	9	,	,	PUNCT
ajmsi-1760	218	10	3752	3752	NUM
ajmsi-1760	218	11	.	.	PUNCT
ajmsi-1760	219	1	https://doi.org/10.1007/5584_2018_331	https://doi.org/10.1007/5584_2018_331	PROPN
ajmsi-1760	219	2	.	.	PUNCT
ajmsi-1760	219	3	dever	dever	PROPN
ajmsi-1760	219	4	,	,	PUNCT
ajmsi-1760	219	5	d.	d.	PROPN
ajmsi-1760	219	6	p.	p.	PROPN
ajmsi-1760	219	7	,	,	PUNCT
ajmsi-1760	219	8	bak	bak	PROPN
ajmsi-1760	219	9	,	,	PUNCT
ajmsi-1760	219	10	r.	r.	PROPN
ajmsi-1760	219	11	o.	o.	PROPN
ajmsi-1760	219	12	,	,	PUNCT
ajmsi-1760	219	13	reinisch	reinisch	PROPN
ajmsi-1760	219	14	,	,	PUNCT
ajmsi-1760	219	15	a.	a.	NOUN
ajmsi-1760	219	16	,	,	PUNCT
ajmsi-1760	219	17	camarena	camarena	PROPN
ajmsi-1760	219	18	,	,	PUNCT
ajmsi-1760	219	19	j.	j.	PROPN
ajmsi-1760	219	20	,	,	PUNCT
ajmsi-1760	219	21	washington	washington	PROPN
ajmsi-1760	219	22	,	,	PUNCT
ajmsi-1760	219	23	g.	g.	PROPN
ajmsi-1760	219	24	,	,	PUNCT
ajmsi-1760	219	25	nicolas	nicolas	PROPN
ajmsi-1760	219	26	,	,	PUNCT
ajmsi-1760	219	27	c.	c.	PROPN
ajmsi-1760	219	28	e.	e.	PROPN
ajmsi-1760	219	29	&	&	CCONJ
ajmsi-1760	219	30	et	et	PROPN
ajmsi-1760	219	31	al	al	PROPN
ajmsi-1760	219	32	.	.	PROPN
ajmsi-1760	219	33	(	(	PUNCT
ajmsi-1760	219	34	2016	2016	NUM
ajmsi-1760	219	35	)	)	PUNCT
ajmsi-1760	219	36	.	.	PUNCT
ajmsi-1760	220	1	crispr/	crispr/	NUM
ajmsi-1760	220	2	cas9	cas9	NOUN
ajmsi-1760	220	3	β	β	X
ajmsi-1760	220	4	-	-	ADJ
ajmsi-1760	220	5	globin	globin	ADJ
ajmsi-1760	220	6	gene	gene	NOUN
ajmsi-1760	220	7	targeting	target	VERB
ajmsi-1760	220	8	in	in	ADP
ajmsi-1760	220	9	human	human	ADJ
ajmsi-1760	220	10	haematopoietic	haematopoietic	ADJ
ajmsi-1760	220	11	stem	stem	NOUN
ajmsi-1760	220	12	cells	cell	NOUN
ajmsi-1760	220	13	.	.	PUNCT
ajmsi-1760	221	1	nature	nature	NOUN
ajmsi-1760	221	2	,	,	PUNCT
ajmsi-1760	221	3	539(7629	539(7629	NUM
ajmsi-1760	221	4	)	)	PUNCT
ajmsi-1760	221	5	,	,	PUNCT
ajmsi-1760	221	6	384–389	384–389	NUM
ajmsi-1760	221	7	.	.	PUNCT
ajmsi-1760	222	1	dewitt	dewitt	PROPN
ajmsi-1760	222	2	,	,	PUNCT
ajmsi-1760	222	3	m.	m.	NOUN
ajmsi-1760	222	4	a.	a.	PROPN
ajmsi-1760	222	5	,	,	PUNCT
ajmsi-1760	222	6	magis	magis	PROPN
ajmsi-1760	222	7	,	,	PUNCT
ajmsi-1760	222	8	w.	w.	PROPN
ajmsi-1760	222	9	,	,	PUNCT
ajmsi-1760	222	10	bray	bray	PROPN
ajmsi-1760	222	11	,	,	PUNCT
ajmsi-1760	222	12	n.	n.	PROPN
ajmsi-1760	222	13	l.	l.	PROPN
ajmsi-1760	222	14	,	,	PUNCT
ajmsi-1760	222	15	wang	wang	PROPN
ajmsi-1760	222	16	,	,	PUNCT
ajmsi-1760	222	17	t.	t.	PROPN
ajmsi-1760	222	18	,	,	PUNCT
ajmsi-1760	222	19	berman	berman	PROPN
ajmsi-1760	222	20	,	,	PUNCT
ajmsi-1760	222	21	j.	j.	PROPN
ajmsi-1760	222	22	r.	r.	PROPN
ajmsi-1760	222	23	,	,	PUNCT
ajmsi-1760	222	24	urbinati	urbinati	PROPN
ajmsi-1760	222	25	,	,	PUNCT
ajmsi-1760	222	26	f.	f.	PROPN
ajmsi-1760	222	27	&	&	CCONJ
ajmsi-1760	222	28	et	et	PROPN
ajmsi-1760	222	29	al	al	PROPN
ajmsi-1760	222	30	.	.	PROPN
ajmsi-1760	223	1	(	(	PUNCT
ajmsi-1760	223	2	2016	2016	NUM
ajmsi-1760	223	3	)	)	PUNCT
ajmsi-1760	223	4	.	.	PUNCT
ajmsi-1760	224	1	selection	selection	NOUN
ajmsi-1760	224	2	-	-	PUNCT
ajmsi-1760	224	3	free	free	ADJ
ajmsi-1760	224	4	genome	genome	NOUN
ajmsi-1760	224	5	editing	editing	NOUN
ajmsi-1760	224	6	of	of	ADP
ajmsi-1760	224	7	the	the	DET
ajmsi-1760	224	8	sickle	sickle	NOUN
ajmsi-1760	224	9	mutation	mutation	NOUN
ajmsi-1760	224	10	in	in	ADP
ajmsi-1760	224	11	human	human	ADJ
ajmsi-1760	224	12	adult	adult	NOUN
ajmsi-1760	224	13	hematopoietic	hematopoietic	ADJ
ajmsi-1760	224	14	stem	stem	NOUN
ajmsi-1760	224	15	/	/	SYM
ajmsi-1760	224	16	progenitor	progenitor	NOUN
ajmsi-1760	224	17	cells	cell	NOUN
ajmsi-1760	224	18	.	.	PUNCT
ajmsi-1760	225	1	science	science	NOUN
ajmsi-1760	225	2	translational	translational	ADJ
ajmsi-1760	225	3	medicine	medicine	NOUN
ajmsi-1760	225	4	,	,	PUNCT
ajmsi-1760	225	5	8(360	8(360	NUM
ajmsi-1760	225	6	)	)	PUNCT
ajmsi-1760	225	7	,	,	PUNCT
ajmsi-1760	225	8	360ra134	360ra134	NUM
ajmsi-1760	225	9	.	.	PUNCT
ajmsi-1760	226	1	https://doi	https://doi	X
ajmsi-1760	226	2	.	.	PUNCT
ajmsi-1760	226	3	org/10.1126	org/10.1126	PROPN
ajmsi-1760	226	4	/	/	SYM
ajmsi-1760	226	5	scitranslmed.aaf9336	scitranslmed.aaf9336	PROPN
ajmsi-1760	226	6	.	.	PUNCT
ajmsi-1760	227	1	eapen	eapen	PROPN
ajmsi-1760	227	2	,	,	PUNCT
ajmsi-1760	227	3	m.	m.	NOUN
ajmsi-1760	227	4	,	,	PUNCT
ajmsi-1760	227	5	brazauskas	brazauskas	PROPN
ajmsi-1760	227	6	,	,	PUNCT
ajmsi-1760	227	7	r.	r.	PROPN
ajmsi-1760	227	8	,	,	PUNCT
ajmsi-1760	227	9	walters	walters	PROPN
ajmsi-1760	227	10	,	,	PUNCT
ajmsi-1760	227	11	m.	m.	PROPN
ajmsi-1760	227	12	c.	c.	PROPN
ajmsi-1760	227	13	,	,	PUNCT
ajmsi-1760	227	14	bernaudin	bernaudin	PROPN
ajmsi-1760	227	15	,	,	PUNCT
ajmsi-1760	227	16	f.	f.	PROPN
ajmsi-1760	227	17	,	,	PUNCT
ajmsi-1760	227	18	bo	bo	NOUN
ajmsi-1760	227	19	-	-	PUNCT
ajmsi-1760	227	20	subait	subait	NOUN
ajmsi-1760	227	21	,	,	PUNCT
ajmsi-1760	227	22	k.	k.	PROPN
ajmsi-1760	227	23	,	,	PUNCT
ajmsi-1760	227	24	fitzhugh	fitzhugh	PROPN
ajmsi-1760	227	25	,	,	PUNCT
ajmsi-1760	227	26	c.	c.	PROPN
ajmsi-1760	227	27	d.	d.	PROPN
ajmsi-1760	227	28	&	&	CCONJ
ajmsi-1760	227	29	et	et	PROPN
ajmsi-1760	227	30	al	al	PROPN
ajmsi-1760	227	31	.	.	PROPN
ajmsi-1760	228	1	(	(	PUNCT
ajmsi-1760	228	2	2019	2019	NUM
ajmsi-1760	228	3	)	)	PUNCT
ajmsi-1760	228	4	.	.	PUNCT
ajmsi-1760	229	1	effect	effect	NOUN
ajmsi-1760	229	2	of	of	ADP
ajmsi-1760	229	3	donor	donor	NOUN
ajmsi-1760	229	4	type	type	NOUN
ajmsi-1760	229	5	and	and	CCONJ
ajmsi-1760	229	6	conditioning	condition	VERB
ajmsi-1760	229	7	regimen	regiman	NOUN
ajmsi-1760	229	8	intensity	intensity	NOUN
ajmsi-1760	229	9	on	on	ADP
ajmsi-1760	229	10	allogeneic	allogeneic	ADJ
ajmsi-1760	229	11	transplantation	transplantation	NOUN
ajmsi-1760	229	12	outcomes	outcome	NOUN
ajmsi-1760	229	13	in	in	ADP
ajmsi-1760	229	14	patients	patient	NOUN
ajmsi-1760	229	15	with	with	ADP
ajmsi-1760	229	16	sickle	sickle	NOUN
ajmsi-1760	229	17	cell	cell	NOUN
ajmsi-1760	229	18	disease	disease	NOUN
ajmsi-1760	229	19	:	:	PUNCT
ajmsi-1760	229	20	a	a	DET
ajmsi-1760	229	21	retrospective	retrospective	ADJ
ajmsi-1760	229	22	multicentre	multicentre	NOUN
ajmsi-1760	229	23	,	,	PUNCT
ajmsi-1760	229	24	cohort	cohort	NOUN
ajmsi-1760	229	25	study	study	NOUN
ajmsi-1760	229	26	.	.	PUNCT
ajmsi-1760	230	1	the	the	DET
ajmsi-1760	230	2	lancet	lancet	PROPN
ajmsi-1760	230	3	haematology	haematology	NOUN
ajmsi-1760	230	4	,	,	PUNCT
ajmsi-1760	230	5	6(11	6(11	NUM
ajmsi-1760	230	6	)	)	PUNCT
ajmsi-1760	230	7	,	,	PUNCT
ajmsi-1760	230	8	e585	e585	PROPN
ajmsi-1760	230	9	-	-	PUNCT
ajmsi-1760	230	10	e596	e596	PROPN
ajmsi-1760	230	11	.	.	PUNCT
ajmsi-1760	231	1	https://	https://	PROPN
ajmsi-1760	231	2	doi.org/10.1016/s2352-3026(19)30154-1	doi.org/10.1016/s2352-3026(19)30154-1	PROPN
ajmsi-1760	231	3	.	.	PUNCT
ajmsi-1760	232	1	ekechi	ekechi	PROPN
ajmsi-1760	232	2	,	,	PUNCT
ajmsi-1760	232	3	h.	h.	PROPN
ajmsi-1760	232	4	o.	o.	PROPN
ajmsi-1760	232	5	,	,	PUNCT
ajmsi-1760	232	6	ikwuka	ikwuka	PROPN
ajmsi-1760	232	7	,	,	PUNCT
ajmsi-1760	232	8	a.	a.	NOUN
ajmsi-1760	232	9	o.	o.	PROPN
ajmsi-1760	232	10	,	,	PUNCT
ajmsi-1760	232	11	udeh	udeh	PROPN
ajmsi-1760	232	12	,	,	PUNCT
ajmsi-1760	232	13	f.	f.	PROPN
ajmsi-1760	232	14	c.	c.	PROPN
ajmsi-1760	232	15	&	&	CCONJ
ajmsi-1760	232	16	abraham	abraham	PROPN
ajmsi-1760	232	17	,	,	PUNCT
ajmsi-1760	232	18	j.	j.	PROPN
ajmsi-1760	232	19	c.	c.	PROPN
ajmsi-1760	232	20	(	(	PUNCT
ajmsi-1760	232	21	2023	2023	NUM
ajmsi-1760	232	22	)	)	PUNCT
ajmsi-1760	232	23	.	.	PUNCT
ajmsi-1760	233	1	effects	effect	NOUN
ajmsi-1760	233	2	of	of	ADP
ajmsi-1760	233	3	ethanol	ethanol	NOUN
ajmsi-1760	233	4	extract	extract	NOUN
ajmsi-1760	233	5	of	of	ADP
ajmsi-1760	233	6	rauwolfia	rauwolfia	NOUN
ajmsi-1760	233	7	vomitoria	vomitoria	NOUN
ajmsi-1760	233	8	leaf	leaf	NOUN
ajmsi-1760	233	9	on	on	ADP
ajmsi-1760	233	10	lipid	lipid	NOUN
ajmsi-1760	233	11	profile	profile	NOUN
ajmsi-1760	233	12	and	and	CCONJ
ajmsi-1760	233	13	cerebellar	cerebellar	ADJ
ajmsi-1760	233	14	histology	histology	NOUN
ajmsi-1760	233	15	in	in	ADP
ajmsi-1760	233	16	cisplatin	cisplatin	NOUN
ajmsi-1760	233	17	-	-	PUNCT
ajmsi-1760	233	18	induced	induce	VERB
ajmsi-1760	233	19	oxidative	oxidative	ADJ
ajmsi-1760	233	20	stress	stress	NOUN
ajmsi-1760	233	21	.	.	PUNCT
ajmsi-1760	234	1	british	british	ADJ
ajmsi-1760	234	2	journal	journal	PROPN
ajmsi-1760	234	3	of	of	ADP
ajmsi-1760	234	4	medical	medical	ADJ
ajmsi-1760	234	5	and	and	CCONJ
ajmsi-1760	234	6	health	health	NOUN
ajmsi-1760	234	7	research	research	NOUN
ajmsi-1760	234	8	,	,	PUNCT
ajmsi-1760	234	9	10(5	10(5	NUM
ajmsi-1760	234	10	)	)	PUNCT
ajmsi-1760	234	11	,	,	PUNCT
ajmsi-1760	234	12	16	16	NUM
ajmsi-1760	234	13	-	-	SYM
ajmsi-1760	234	14	39	39	NUM
ajmsi-1760	234	15	.	.	PUNCT
ajmsi-1760	235	1	https://doi.org/10.5281/zenodo.8042521	https://doi.org/10.5281/zenodo.8042521	PROPN
ajmsi-1760	235	2	.	.	PUNCT
ajmsi-1760	236	1	eshka	eshka	PROPN
ajmsi-1760	236	2	,	,	PUNCT
ajmsi-1760	236	3	s.	s.	PROPN
ajmsi-1760	236	4	f.	f.	PROPN
ajmsi-1760	236	5	a.	a.	PROPN
ajmsi-1760	236	6	,	,	PUNCT
ajmsi-1760	236	7	bahador	bahador	NOUN
ajmsi-1760	236	8	,	,	PUNCT
ajmsi-1760	236	9	m.	m.	NOUN
ajmsi-1760	236	10	,	,	PUNCT
ajmsi-1760	236	11	gordan	gordan	PROPN
ajmsi-1760	236	12	,	,	PUNCT
ajmsi-1760	236	13	m.	m.	NOUN
ajmsi-1760	236	14	m.	m.	NOUN
ajmsi-1760	236	15	,	,	PUNCT
ajmsi-1760	236	16	karbasi	karbasi	PROPN
ajmsi-1760	236	17	,	,	PUNCT
ajmsi-1760	236	18	s.	s.	PROPN
ajmsi-1760	236	19	,	,	PUNCT
ajmsi-1760	236	20	tabar	tabar	PROPN
ajmsi-1760	236	21	,	,	PUNCT
ajmsi-1760	236	22	z.	z.	PROPN
ajmsi-1760	236	23	m.	m.	PROPN
ajmsi-1760	236	24	&	&	CCONJ
ajmsi-1760	236	25	basiri	basiri	PROPN
ajmsi-1760	236	26	,	,	PUNCT
ajmsi-1760	236	27	m.	m.	NOUN
ajmsi-1760	236	28	(	(	PUNCT
ajmsi-1760	236	29	2022	2022	NUM
ajmsi-1760	236	30	)	)	PUNCT
ajmsi-1760	236	31	.	.	PUNCT
ajmsi-1760	237	1	a	a	DET
ajmsi-1760	237	2	systematic	systematic	ADJ
ajmsi-1760	237	3	review	review	NOUN
ajmsi-1760	237	4	of	of	ADP
ajmsi-1760	237	5	gene	gene	NOUN
ajmsi-1760	237	6	editing	edit	VERB
ajmsi-1760	237	7	clinical	clinical	ADJ
ajmsi-1760	237	8	trials	trial	NOUN
ajmsi-1760	237	9	.	.	PUNCT
ajmsi-1760	238	1	medrxiv	medrxiv	PROPN
ajmsi-1760	238	2	,	,	PUNCT
ajmsi-1760	238	3	https://doi.org	https://doi.org	PROPN
ajmsi-1760	238	4	/10.1101/2022.11.24.22282599	/10.1101/2022.11.24.22282599	PROPN
ajmsi-1760	238	5	.	.	PUNCT
ajmsi-1760	239	1	frangoul	frangoul	PROPN
ajmsi-1760	239	2	,	,	PUNCT
ajmsi-1760	239	3	h.	h.	PROPN
ajmsi-1760	239	4	,	,	PUNCT
ajmsi-1760	239	5	altshuler	altshuler	PROPN
ajmsi-1760	239	6	,	,	PUNCT
ajmsi-1760	239	7	d.	d.	PROPN
ajmsi-1760	239	8	,	,	PUNCT
ajmsi-1760	239	9	cappellini	cappellini	PROPN
ajmsi-1760	239	10	,	,	PUNCT
ajmsi-1760	239	11	m.	m.	PROPN
ajmsi-1760	239	12	d.	d.	PROPN
ajmsi-1760	239	13	,	,	PUNCT
ajmsi-1760	239	14	chen	chen	PROPN
ajmsi-1760	239	15	,	,	PUNCT
ajmsi-1760	239	16	y.	y.	PROPN
ajmsi-1760	239	17	s.	s.	PROPN
ajmsi-1760	239	18	,	,	PUNCT
ajmsi-1760	239	19	domm	domm	NOUN
ajmsi-1760	239	20	,	,	PUNCT
ajmsi-1760	239	21	j.	j.	PROPN
ajmsi-1760	239	22	,	,	PUNCT
ajmsi-1760	239	23	eustace	eustace	PROPN
ajmsi-1760	239	24	,	,	PUNCT
ajmsi-1760	239	25	b.	b.	PROPN
ajmsi-1760	239	26	k.	k.	PROPN
ajmsi-1760	239	27	&	&	CCONJ
ajmsi-1760	239	28	et	et	PROPN
ajmsi-1760	239	29	al	al	PROPN
ajmsi-1760	239	30	.	.	PROPN
ajmsi-1760	239	31	(	(	PUNCT
ajmsi-1760	239	32	2021	2021	NUM
ajmsi-1760	239	33	)	)	PUNCT
ajmsi-1760	239	34	.	.	PUNCT
ajmsi-1760	240	1	crispr	crispr	ADJ
ajmsi-1760	240	2	-	-	PUNCT
ajmsi-1760	240	3	cas9	cas9	NOUN
ajmsi-1760	240	4	gene	gene	NOUN
ajmsi-1760	240	5	editing	edit	VERB
ajmsi-1760	240	6	for	for	ADP
ajmsi-1760	240	7	sickle	sickle	NOUN
ajmsi-1760	240	8	cell	cell	NOUN
ajmsi-1760	240	9	disease	disease	NOUN
ajmsi-1760	240	10	and	and	CCONJ
ajmsi-1760	240	11	β	β	NOUN
ajmsi-1760	240	12	-	-	NOUN
ajmsi-1760	240	13	thalassemia	thalassemia	NOUN
ajmsi-1760	240	14	.	.	PUNCT
ajmsi-1760	241	1	pa	pa	PROPN
ajmsi-1760	241	2	ge	ge	PROPN
ajmsi-1760	241	3	54	54	NUM
ajmsi-1760	241	4	https://journals.e-palli.com/home/index.php/ajmsi	https://journals.e-palli.com/home/index.php/ajmsi	PROPN
ajmsi-1760	241	5	am	be	AUX
ajmsi-1760	241	6	.	.	PUNCT
ajmsi-1760	242	1	j.	j.	PROPN
ajmsi-1760	242	2	med	med	PROPN
ajmsi-1760	242	3	.	.	PUNCT
ajmsi-1760	243	1	sci	sci	PROPN
ajmsi-1760	243	2	.	.	PUNCT
ajmsi-1760	243	3	innov	innov	PROPN
ajmsi-1760	243	4	.	.	PUNCT
ajmsi-1760	244	1	2(2	2(2	NUM
ajmsi-1760	244	2	)	)	PUNCT
ajmsi-1760	244	3	44	44	NUM
ajmsi-1760	244	4	-	-	SYM
ajmsi-1760	244	5	56	56	NUM
ajmsi-1760	244	6	,	,	PUNCT
ajmsi-1760	244	7	2023	2023	NUM
ajmsi-1760	244	8	the	the	DET
ajmsi-1760	244	9	new	new	PROPN
ajmsi-1760	244	10	england	england	PROPN
ajmsi-1760	244	11	journal	journal	PROPN
ajmsi-1760	244	12	of	of	ADP
ajmsi-1760	244	13	medicine	medicine	NOUN
ajmsi-1760	244	14	,	,	PUNCT
ajmsi-1760	244	15	384(3	384(3	NUM
ajmsi-1760	244	16	)	)	PUNCT
ajmsi-1760	244	17	,	,	PUNCT
ajmsi-1760	244	18	252–260	252–260	NUM
ajmsi-1760	244	19	.	.	PUNCT
ajmsi-1760	245	1	gaston	gaston	PROPN
ajmsi-1760	245	2	,	,	PUNCT
ajmsi-1760	245	3	m.	m.	PROPN
ajmsi-1760	245	4	h.	h.	PROPN
ajmsi-1760	245	5	&	&	CCONJ
ajmsi-1760	245	6	et	et	PROPN
ajmsi-1760	245	7	al	al	PROPN
ajmsi-1760	245	8	.	.	PROPN
ajmsi-1760	246	1	(	(	PUNCT
ajmsi-1760	246	2	1986	1986	NUM
ajmsi-1760	246	3	)	)	PUNCT
ajmsi-1760	246	4	.	.	PUNCT
ajmsi-1760	247	1	prophylaxis	prophylaxi	VERB
ajmsi-1760	247	2	with	with	ADP
ajmsi-1760	247	3	oral	oral	ADJ
ajmsi-1760	247	4	penicillin	penicillin	NOUN
ajmsi-1760	247	5	in	in	ADP
ajmsi-1760	247	6	children	child	NOUN
ajmsi-1760	247	7	with	with	ADP
ajmsi-1760	247	8	sickle	sickle	NOUN
ajmsi-1760	247	9	cell	cell	NOUN
ajmsi-1760	247	10	anaemia	anaemia	NOUN
ajmsi-1760	247	11	:	:	PUNCT
ajmsi-1760	247	12	a	a	DET
ajmsi-1760	247	13	randomized	randomized	ADJ
ajmsi-1760	247	14	trial	trial	NOUN
ajmsi-1760	247	15	.	.	PUNCT
ajmsi-1760	248	1	the	the	DET
ajmsi-1760	248	2	new	new	PROPN
ajmsi-1760	248	3	england	england	PROPN
ajmsi-1760	248	4	journal	journal	PROPN
ajmsi-1760	248	5	of	of	ADP
ajmsi-1760	248	6	medicine	medicine	NOUN
ajmsi-1760	248	7	,	,	PUNCT
ajmsi-1760	248	8	1593(52	1593(52	NUM
ajmsi-1760	248	9	)	)	PUNCT
ajmsi-1760	248	10	,	,	PUNCT
ajmsi-1760	248	11	314–52	314–52	NUM
ajmsi-1760	248	12	.	.	PUNCT
ajmsi-1760	249	1	gluckman	gluckman	PROPN
ajmsi-1760	249	2	,	,	PUNCT
ajmsi-1760	249	3	e.	e.	PROPN
ajmsi-1760	249	4	,	,	PUNCT
ajmsi-1760	249	5	cappelli	cappelli	PROPN
ajmsi-1760	249	6	,	,	PUNCT
ajmsi-1760	249	7	b.	b.	PROPN
ajmsi-1760	249	8	,	,	PUNCT
ajmsi-1760	249	9	bernaudin	bernaudin	PROPN
ajmsi-1760	249	10	,	,	PUNCT
ajmsi-1760	249	11	f.	f.	PROPN
ajmsi-1760	249	12	,	,	PUNCT
ajmsi-1760	249	13	labopin	labopin	PROPN
ajmsi-1760	249	14	,	,	PUNCT
ajmsi-1760	249	15	m.	m.	NOUN
ajmsi-1760	249	16	,	,	PUNCT
ajmsi-1760	249	17	volt	volt	NOUN
ajmsi-1760	249	18	,	,	PUNCT
ajmsi-1760	249	19	f.	f.	PROPN
ajmsi-1760	249	20	,	,	PUNCT
ajmsi-1760	249	21	carreras	carreras	PROPN
ajmsi-1760	249	22	,	,	PUNCT
ajmsi-1760	249	23	j.	j.	PROPN
ajmsi-1760	249	24	&	&	CCONJ
ajmsi-1760	249	25	et	et	PROPN
ajmsi-1760	249	26	al	al	PROPN
ajmsi-1760	249	27	.	.	PROPN
ajmsi-1760	249	28	(	(	PUNCT
ajmsi-1760	249	29	2017	2017	NUM
ajmsi-1760	249	30	)	)	PUNCT
ajmsi-1760	249	31	.	.	PUNCT
ajmsi-1760	250	1	sickle	sickle	NOUN
ajmsi-1760	250	2	cell	cell	NOUN
ajmsi-1760	250	3	disease	disease	NOUN
ajmsi-1760	250	4	:	:	PUNCT
ajmsi-1760	250	5	an	an	DET
ajmsi-1760	250	6	international	international	ADJ
ajmsi-1760	250	7	survey	survey	NOUN
ajmsi-1760	250	8	of	of	ADP
ajmsi-1760	250	9	results	result	NOUN
ajmsi-1760	250	10	of	of	ADP
ajmsi-1760	250	11	hla	hla	NOUN
ajmsi-1760	250	12	-	-	PUNCT
ajmsi-1760	250	13	identical	identical	ADJ
ajmsi-1760	250	14	sibling	sible	VERB
ajmsi-1760	250	15	hematopoietic	hematopoietic	ADJ
ajmsi-1760	250	16	stem	stem	NOUN
ajmsi-1760	250	17	cell	cell	NOUN
ajmsi-1760	250	18	transplantation	transplantation	NOUN
ajmsi-1760	250	19	.	.	PUNCT
ajmsi-1760	251	1	blood	blood	NOUN
ajmsi-1760	251	2	,	,	PUNCT
ajmsi-1760	251	3	129	129	NUM
ajmsi-1760	251	4	,	,	PUNCT
ajmsi-1760	251	5	1548	1548	NUM
ajmsi-1760	251	6	-	-	SYM
ajmsi-1760	251	7	1556	1556	NUM
ajmsi-1760	251	8	.	.	PUNCT
ajmsi-1760	252	1	guo	guo	PROPN
ajmsi-1760	252	2	,	,	PUNCT
ajmsi-1760	252	3	n.	n.	PROPN
ajmsi-1760	252	4	,	,	PUNCT
ajmsi-1760	252	5	liu	liu	PROPN
ajmsi-1760	252	6	,	,	PUNCT
ajmsi-1760	252	7	j.	j.	PROPN
ajmsi-1760	252	8	b.	b.	PROPN
ajmsi-1760	252	9	,	,	PUNCT
ajmsi-1760	252	10	li	li	PROPN
ajmsi-1760	252	11	,	,	PUNCT
ajmsi-1760	252	12	w.	w.	PROPN
ajmsi-1760	252	13	,	,	PUNCT
ajmsi-1760	252	14	ma	ma	PROPN
ajmsi-1760	252	15	,	,	PUNCT
ajmsi-1760	252	16	y.	y.	PROPN
ajmsi-1760	252	17	s.	s.	PROPN
ajmsi-1760	252	18	&	&	CCONJ
ajmsi-1760	252	19	fu	fu	PROPN
ajmsi-1760	252	20	d.	d.	PROPN
ajmsi-1760	252	21	(	(	PUNCT
ajmsi-1760	252	22	2022	2022	NUM
ajmsi-1760	252	23	)	)	PUNCT
ajmsi-1760	252	24	.	.	PUNCT
ajmsi-1760	253	1	the	the	DET
ajmsi-1760	253	2	power	power	NOUN
ajmsi-1760	253	3	and	and	CCONJ
ajmsi-1760	253	4	the	the	DET
ajmsi-1760	253	5	promise	promise	NOUN
ajmsi-1760	253	6	of	of	ADP
ajmsi-1760	253	7	crispr	crispr	ADJ
ajmsi-1760	253	8	/	/	SYM
ajmsi-1760	253	9	cas9	cas9	NOUN
ajmsi-1760	253	10	genome	genome	NOUN
ajmsi-1760	253	11	editing	editing	NOUN
ajmsi-1760	253	12	for	for	ADP
ajmsi-1760	253	13	clinical	clinical	ADJ
ajmsi-1760	253	14	application	application	NOUN
ajmsi-1760	253	15	with	with	ADP
ajmsi-1760	253	16	gene	gene	NOUN
ajmsi-1760	253	17	therapy	therapy	NOUN
ajmsi-1760	253	18	.	.	PUNCT
ajmsi-1760	254	1	journal	journal	PROPN
ajmsi-1760	254	2	of	of	ADP
ajmsi-1760	254	3	advanced	advanced	ADJ
ajmsi-1760	254	4	research	research	NOUN
ajmsi-1760	254	5	,	,	PUNCT
ajmsi-1760	254	6	40	40	NUM
ajmsi-1760	254	7	,	,	PUNCT
ajmsi-1760	254	8	135–152	135–152	NUM
ajmsi-1760	254	9	.	.	PUNCT
ajmsi-1760	255	1	https://doi	https://doi	X
ajmsi-1760	255	2	.	.	PUNCT
ajmsi-1760	255	3	org/10.1016	org/10.1016	PROPN
ajmsi-1760	255	4	/	/	SYM
ajmsi-1760	255	5	j.jare.2021.11.018	j.jare.2021.11.018	PROPN
ajmsi-1760	255	6	.	.	PUNCT
ajmsi-1760	256	1	hall	hall	PROPN
ajmsi-1760	256	2	,	,	PUNCT
ajmsi-1760	256	3	j.	j.	PROPN
ajmsi-1760	256	4	e.	e.	PROPN
ajmsi-1760	256	5	&	&	CCONJ
ajmsi-1760	256	6	hall	hall	PROPN
ajmsi-1760	256	7	,	,	PUNCT
ajmsi-1760	256	8	m.	m.	PROPN
ajmsi-1760	256	9	e.	e.	PROPN
ajmsi-1760	256	10	(	(	PUNCT
ajmsi-1760	256	11	2020	2020	NUM
ajmsi-1760	256	12	)	)	PUNCT
ajmsi-1760	256	13	.	.	PUNCT
ajmsi-1760	257	1	guyton	guyton	PROPN
ajmsi-1760	257	2	and	and	CCONJ
ajmsi-1760	257	3	hall	hall	PROPN
ajmsi-1760	257	4	textbook	textbook	NOUN
ajmsi-1760	257	5	of	of	ADP
ajmsi-1760	257	6	medical	medical	ADJ
ajmsi-1760	257	7	physiology	physiology	NOUN
ajmsi-1760	257	8	.	.	PUNCT
ajmsi-1760	258	1	14th	14th	ADJ
ajmsi-1760	258	2	edition	edition	NOUN
ajmsi-1760	258	3	.	.	PUNCT
ajmsi-1760	259	1	elsevier	elsevier	PROPN
ajmsi-1760	259	2	,	,	PUNCT
ajmsi-1760	259	3	p.	p.	NOUN
ajmsi-1760	259	4	441446	441446	NUM
ajmsi-1760	259	5	.	.	PUNCT
ajmsi-1760	260	1	hoban	hoban	PROPN
ajmsi-1760	260	2	,	,	PUNCT
ajmsi-1760	260	3	m.	m.	NOUN
ajmsi-1760	260	4	d.	d.	PROPN
ajmsi-1760	260	5	,	,	PUNCT
ajmsi-1760	260	6	lumaquin	lumaquin	PROPN
ajmsi-1760	260	7	,	,	PUNCT
ajmsi-1760	260	8	d.	d.	PROPN
ajmsi-1760	260	9	,	,	PUNCT
ajmsi-1760	260	10	kuo	kuo	PROPN
ajmsi-1760	260	11	,	,	PUNCT
ajmsi-1760	260	12	c.	c.	PROPN
ajmsi-1760	260	13	y.	y.	PROPN
ajmsi-1760	260	14	,	,	PUNCT
ajmsi-1760	260	15	romero	romero	PROPN
ajmsi-1760	260	16	,	,	PUNCT
ajmsi-1760	260	17	z.	z.	PROPN
ajmsi-1760	260	18	,	,	PUNCT
ajmsi-1760	260	19	long	long	ADV
ajmsi-1760	260	20	,	,	PUNCT
ajmsi-1760	260	21	j.	j.	PROPN
ajmsi-1760	260	22	,	,	PUNCT
ajmsi-1760	260	23	ho	ho	PROPN
ajmsi-1760	260	24	,	,	PUNCT
ajmsi-1760	260	25	m.	m.	NOUN
ajmsi-1760	260	26	&	&	CCONJ
ajmsi-1760	260	27	et	et	PROPN
ajmsi-1760	260	28	al	al	PROPN
ajmsi-1760	260	29	.	.	PROPN
ajmsi-1760	260	30	(	(	PUNCT
ajmsi-1760	260	31	2016)a	2016)a	NUM
ajmsi-1760	260	32	.	.	NOUN
ajmsi-1760	260	33	crispr	crispr	PROPN
ajmsi-1760	260	34	/	/	SYM
ajmsi-1760	260	35	cas9mediated	cas9mediate	VERB
ajmsi-1760	260	36	correction	correction	NOUN
ajmsi-1760	260	37	of	of	ADP
ajmsi-1760	260	38	the	the	DET
ajmsi-1760	260	39	sickle	sickle	NOUN
ajmsi-1760	260	40	mutation	mutation	NOUN
ajmsi-1760	260	41	in	in	ADP
ajmsi-1760	260	42	human	human	ADJ
ajmsi-1760	260	43	cd34	cd34	PROPN
ajmsi-1760	260	44	+	+	NUM
ajmsi-1760	260	45	cells	cell	NOUN
ajmsi-1760	260	46	.	.	PUNCT
ajmsi-1760	261	1	molecular	molecular	ADJ
ajmsi-1760	261	2	therapy	therapy	NOUN
ajmsi-1760	261	3	,	,	PUNCT
ajmsi-1760	261	4	24(9	24(9	NUM
ajmsi-1760	261	5	)	)	PUNCT
ajmsi-1760	261	6	,	,	PUNCT
ajmsi-1760	261	7	1561–1569	1561–1569	NUM
ajmsi-1760	261	8	.	.	PUNCT
ajmsi-1760	261	9	hoban	hoban	PROPN
ajmsi-1760	261	10	,	,	PUNCT
ajmsi-1760	261	11	m.	m.	NOUN
ajmsi-1760	261	12	d.	d.	PROPN
ajmsi-1760	261	13	,	,	PUNCT
ajmsi-1760	261	14	orkin	orkin	PROPN
ajmsi-1760	261	15	,	,	PUNCT
ajmsi-1760	261	16	s.	s.	PROPN
ajmsi-1760	261	17	h.	h.	PROPN
ajmsi-1760	261	18	&	&	CCONJ
ajmsi-1760	261	19	bauer	bauer	PROPN
ajmsi-1760	261	20	,	,	PUNCT
ajmsi-1760	261	21	d.	d.	PROPN
ajmsi-1760	261	22	e.	e.	PROPN
ajmsi-1760	261	23	(	(	PUNCT
ajmsi-1760	261	24	2016)b	2016)b	NUM
ajmsi-1760	261	25	.	.	PUNCT
ajmsi-1760	261	26	genetic	genetic	ADJ
ajmsi-1760	261	27	treatment	treatment	NOUN
ajmsi-1760	261	28	of	of	ADP
ajmsi-1760	261	29	a	a	DET
ajmsi-1760	261	30	molecular	molecular	ADJ
ajmsi-1760	261	31	disorder	disorder	NOUN
ajmsi-1760	261	32	:	:	PUNCT
ajmsi-1760	261	33	gene	gene	NOUN
ajmsi-1760	261	34	therapy	therapy	NOUN
ajmsi-1760	261	35	approaches	approach	VERB
ajmsi-1760	261	36	to	to	ADP
ajmsi-1760	261	37	sickle	sickle	VERB
ajmsi-1760	261	38	cell	cell	NOUN
ajmsi-1760	261	39	disease	disease	NOUN
ajmsi-1760	261	40	.	.	PUNCT
ajmsi-1760	262	1	blood	blood	NOUN
ajmsi-1760	262	2	,	,	PUNCT
ajmsi-1760	262	3	127(7	127(7	NUM
ajmsi-1760	262	4	)	)	PUNCT
ajmsi-1760	262	5	,	,	PUNCT
ajmsi-1760	262	6	839–848	839–848	NUM
ajmsi-1760	262	7	.	.	PUNCT
ajmsi-1760	263	1	hossain	hossain	PROPN
ajmsi-1760	263	2	,	,	PUNCT
ajmsi-1760	263	3	m.	m.	NOUN
ajmsi-1760	263	4	a.	a.	PROPN
ajmsi-1760	263	5	&	&	CCONJ
ajmsi-1760	263	6	bungert	bungert	PROPN
ajmsi-1760	263	7	,	,	PUNCT
ajmsi-1760	263	8	j.	j.	PROPN
ajmsi-1760	263	9	(	(	PUNCT
ajmsi-1760	263	10	2017	2017	NUM
ajmsi-1760	263	11	)	)	PUNCT
ajmsi-1760	263	12	.	.	PUNCT
ajmsi-1760	264	1	genome	genome	NOUN
ajmsi-1760	264	2	editing	editing	NOUN
ajmsi-1760	264	3	for	for	ADP
ajmsi-1760	264	4	sickle	sickle	NOUN
ajmsi-1760	264	5	cell	cell	NOUN
ajmsi-1760	264	6	disease	disease	NOUN
ajmsi-1760	264	7	:	:	PUNCT
ajmsi-1760	264	8	a	a	DET
ajmsi-1760	264	9	little	little	ADJ
ajmsi-1760	264	10	bcl11a	bcl11a	NOUN
ajmsi-1760	264	11	goes	go	VERB
ajmsi-1760	264	12	a	a	DET
ajmsi-1760	264	13	long	long	ADJ
ajmsi-1760	264	14	way	way	NOUN
ajmsi-1760	264	15	.	.	PUNCT
ajmsi-1760	265	1	molecular	molecular	ADJ
ajmsi-1760	265	2	therapy	therapy	NOUN
ajmsi-1760	265	3	,	,	PUNCT
ajmsi-1760	265	4	25(3	25(3	NUM
ajmsi-1760	265	5	)	)	PUNCT
ajmsi-1760	265	6	,	,	PUNCT
ajmsi-1760	265	7	561	561	NUM
ajmsi-1760	265	8	–	–	PUNCT
ajmsi-1760	265	9	562	562	NUM
ajmsi-1760	265	10	.	.	PUNCT
ajmsi-1760	266	1	https://doi	https://doi	X
ajmsi-1760	266	2	.	.	PUNCT
ajmsi-1760	267	1	org/10.1016	org/10.1016	PROPN
ajmsi-1760	267	2	/	/	SYM
ajmsi-1760	267	3	j.ymthe.2017.02.003	j.ymthe.2017.02.003	PROPN
ajmsi-1760	267	4	.	.	PUNCT
ajmsi-1760	268	1	ikwuka	ikwuka	PROPN
ajmsi-1760	268	2	,	,	PUNCT
ajmsi-1760	268	3	a.	a.	NOUN
ajmsi-1760	268	4	o.	o.	NOUN
ajmsi-1760	268	5	(	(	PUNCT
ajmsi-1760	268	6	2015	2015	NUM
ajmsi-1760	268	7	)	)	PUNCT
ajmsi-1760	268	8	.	.	PUNCT
ajmsi-1760	269	1	risk	risk	NOUN
ajmsi-1760	269	2	factors	factor	NOUN
ajmsi-1760	269	3	for	for	ADP
ajmsi-1760	269	4	the	the	DET
ajmsi-1760	269	5	pathogenesis	pathogenesis	NOUN
ajmsi-1760	269	6	of	of	ADP
ajmsi-1760	269	7	diabetes	diabetes	NOUN
ajmsi-1760	269	8	mellitus	mellitus	NOUN
ajmsi-1760	269	9	type	type	VERB
ajmsi-1760	269	10	2	2	NUM
ajmsi-1760	269	11	.	.	PUNCT
ajmsi-1760	269	12	materials	material	NOUN
ajmsi-1760	269	13	of	of	ADP
ajmsi-1760	269	14	84th	84th	ADJ
ajmsi-1760	269	15	scientific	scientific	ADJ
ajmsi-1760	269	16	and	and	CCONJ
ajmsi-1760	269	17	practical	practical	ADJ
ajmsi-1760	269	18	conference	conference	NOUN
ajmsi-1760	269	19	of	of	ADP
ajmsi-1760	269	20	students	student	NOUN
ajmsi-1760	269	21	and	and	CCONJ
ajmsi-1760	269	22	young	young	ADJ
ajmsi-1760	269	23	scientists	scientist	NOUN
ajmsi-1760	269	24	with	with	ADP
ajmsi-1760	269	25	international	international	ADJ
ajmsi-1760	269	26	participation	participation	NOUN
ajmsi-1760	269	27	“	"	PUNCT
ajmsi-1760	269	28	innovations	innovation	NOUN
ajmsi-1760	269	29	in	in	ADP
ajmsi-1760	269	30	medicine	medicine	NOUN
ajmsi-1760	269	31	”	"	PUNCT
ajmsi-1760	269	32	,	,	PUNCT
ajmsi-1760	269	33	p.	p.	NOUN
ajmsi-1760	269	34	19	19	NUM
ajmsi-1760	269	35	.	.	PUNCT
ajmsi-1760	270	1	available	available	ADJ
ajmsi-1760	270	2	online	online	ADV
ajmsi-1760	270	3	:	:	PUNCT
ajmsi-1760	271	1	http://www.ifnmu	http://www.ifnmu	NOUN
ajmsi-1760	271	2	.	.	PUNCT
ajmsi-1760	272	1	edu.ua/images/snt/files/konferenciya/tezu_2015	edu.ua/images/snt/files/konferenciya/tezu_2015	NOUN
ajmsi-1760	272	2	.	.	PUNCT
ajmsi-1760	273	1	pdf	pdf	PROPN
ajmsi-1760	273	2	ikwuka	ikwuka	PROPN
ajmsi-1760	273	3	,	,	PUNCT
ajmsi-1760	273	4	a.	a.	NOUN
ajmsi-1760	273	5	o.	o.	PROPN
ajmsi-1760	273	6	(	(	PUNCT
ajmsi-1760	273	7	2017)a	2017)a	NUM
ajmsi-1760	273	8	.	.	PUNCT
ajmsi-1760	273	9	dyslipidemia	dyslipidemia	NOUN
ajmsi-1760	273	10	risk	risk	NOUN
ajmsi-1760	273	11	severity	severity	NOUN
ajmsi-1760	273	12	in	in	ADP
ajmsi-1760	273	13	patients	patient	NOUN
ajmsi-1760	273	14	with	with	ADP
ajmsi-1760	273	15	diabetes	diabetes	NOUN
ajmsi-1760	273	16	mellitus	mellitus	NOUN
ajmsi-1760	273	17	type	type	VERB
ajmsi-1760	273	18	2	2	NUM
ajmsi-1760	273	19	and	and	CCONJ
ajmsi-1760	273	20	essential	essential	ADJ
ajmsi-1760	273	21	hypertension	hypertension	NOUN
ajmsi-1760	273	22	.	.	PUNCT
ajmsi-1760	274	1	journal	journal	NOUN
ajmsi-1760	274	2	of	of	ADP
ajmsi-1760	274	3	the	the	DET
ajmsi-1760	274	4	21st	21st	ADJ
ajmsi-1760	274	5	international	international	ADJ
ajmsi-1760	274	6	medical	medical	ADJ
ajmsi-1760	274	7	congress	congress	PROPN
ajmsi-1760	274	8	of	of	ADP
ajmsi-1760	274	9	students	student	NOUN
ajmsi-1760	274	10	and	and	CCONJ
ajmsi-1760	274	11	young	young	ADJ
ajmsi-1760	274	12	scientists	scientist	NOUN
ajmsi-1760	274	13	,	,	PUNCT
ajmsi-1760	274	14	p.	p.	NOUN
ajmsi-1760	274	15	59	59	NUM
ajmsi-1760	274	16	.	.	PUNCT
ajmsi-1760	275	1	ikwuka	ikwuka	PROPN
ajmsi-1760	275	2	,	,	PUNCT
ajmsi-1760	275	3	a.	a.	NOUN
ajmsi-1760	275	4	o.	o.	PROPN
ajmsi-1760	275	5	(	(	PUNCT
ajmsi-1760	275	6	2017)b	2017)b	NUM
ajmsi-1760	275	7	.	.	PUNCT
ajmsi-1760	276	1	effectiveness	effectiveness	NOUN
ajmsi-1760	276	2	of	of	ADP
ajmsi-1760	276	3	dapagliflozin	dapagliflozin	PROPN
ajmsi-1760	276	4	in	in	ADP
ajmsi-1760	276	5	patients	patient	NOUN
ajmsi-1760	276	6	with	with	ADP
ajmsi-1760	276	7	diabetes	diabetes	NOUN
ajmsi-1760	276	8	mellitus	mellitus	NOUN
ajmsi-1760	276	9	type	type	VERB
ajmsi-1760	276	10	2	2	NUM
ajmsi-1760	276	11	and	and	CCONJ
ajmsi-1760	276	12	essential	essential	ADJ
ajmsi-1760	276	13	hypertension	hypertension	NOUN
ajmsi-1760	276	14	.	.	PUNCT
ajmsi-1760	277	1	book	book	NOUN
ajmsi-1760	277	2	of	of	ADP
ajmsi-1760	277	3	abstracts	abstract	NOUN
ajmsi-1760	277	4	of	of	ADP
ajmsi-1760	277	5	the	the	DET
ajmsi-1760	277	6	7th	7th	ADJ
ajmsi-1760	277	7	international	international	ADJ
ajmsi-1760	277	8	students	student	NOUN
ajmsi-1760	277	9	’	'	PUNCT
ajmsi-1760	277	10	scientific	scientific	ADJ
ajmsi-1760	277	11	conference	conference	NOUN
ajmsi-1760	277	12	of	of	ADP
ajmsi-1760	277	13	young	young	ADJ
ajmsi-1760	277	14	medical	medical	ADJ
ajmsi-1760	277	15	researchers	researcher	NOUN
ajmsi-1760	277	16	,	,	PUNCT
ajmsi-1760	277	17	p.	p.	NOUN
ajmsi-1760	277	18	102	102	NUM
ajmsi-1760	277	19	.	.	PUNCT
ajmsi-1760	278	1	available	available	ADJ
ajmsi-1760	278	2	online	online	ADV
ajmsi-1760	278	3	:	:	PUNCT
ajmsi-1760	279	1	http://www.stn	http://www.stn	PROPN
ajmsi-1760	279	2	.	.	PUNCT
ajmsi-1760	280	1	umed.wroc.pl/files/lm/accepted_papers.16113.pdf	umed.wroc.pl/files/lm/accepted_papers.16113.pdf	PROPN
ajmsi-1760	280	2	ikwuka	ikwuka	PROPN
ajmsi-1760	280	3	,	,	PUNCT
ajmsi-1760	280	4	a.	a.	NOUN
ajmsi-1760	280	5	o.	o.	PROPN
ajmsi-1760	280	6	(	(	PUNCT
ajmsi-1760	280	7	2017)c	2017)c	NUM
ajmsi-1760	280	8	.	.	PUNCT
ajmsi-1760	280	9	influence	influence	NOUN
ajmsi-1760	280	10	of	of	ADP
ajmsi-1760	280	11	dyslipidemia	dyslipidemia	NOUN
ajmsi-1760	280	12	in	in	ADP
ajmsi-1760	280	13	patients	patient	NOUN
ajmsi-1760	280	14	with	with	ADP
ajmsi-1760	280	15	diabetes	diabetes	NOUN
ajmsi-1760	280	16	mellitus	mellitus	NOUN
ajmsi-1760	280	17	type	type	VERB
ajmsi-1760	280	18	2	2	NUM
ajmsi-1760	280	19	and	and	CCONJ
ajmsi-1760	280	20	essential	essential	ADJ
ajmsi-1760	280	21	hypertension	hypertension	NOUN
ajmsi-1760	280	22	.	.	PUNCT
ajmsi-1760	281	1	the	the	DET
ajmsi-1760	281	2	pharma	pharma	PROPN
ajmsi-1760	281	3	innovation	innovation	NOUN
ajmsi-1760	281	4	journal	journal	PROPN
ajmsi-1760	281	5	,	,	PUNCT
ajmsi-1760	281	6	6(3	6(3	NUM
ajmsi-1760	281	7	)	)	PUNCT
ajmsi-1760	281	8	,	,	PUNCT
ajmsi-1760	281	9	101103	101103	NUM
ajmsi-1760	281	10	.	.	PUNCT
ajmsi-1760	282	1	available	available	ADJ
ajmsi-1760	282	2	online	online	ADV
ajmsi-1760	282	3	:	:	PUNCT
ajmsi-1760	283	1	http://www.thepharmajournal	http://www.thepharmajournal	ADJ
ajmsi-1760	283	2	.	.	PUNCT
ajmsi-1760	283	3	com	com	NOUN
ajmsi-1760	283	4	/	/	SYM
ajmsi-1760	283	5	archives/?year=2017&vol=6&issue=3&part	archives/?year=2017&vol=6&issue=3&part	PROPN
ajmsi-1760	283	6	=	=	SYM
ajmsi-1760	283	7	b	b	NOUN
ajmsi-1760	283	8	ikwuka	ikwuka	NOUN
ajmsi-1760	283	9	,	,	PUNCT
ajmsi-1760	283	10	a.	a.	PROPN
ajmsi-1760	283	11	o.	o.	PROPN
ajmsi-1760	283	12	&	&	CCONJ
ajmsi-1760	283	13	haman	haman	PROPN
ajmsi-1760	283	14	,	,	PUNCT
ajmsi-1760	283	15	i.	i.	PROPN
ajmsi-1760	283	16	o.	o.	PROPN
ajmsi-1760	283	17	(	(	PUNCT
ajmsi-1760	283	18	2017)d	2017)d	NOUN
ajmsi-1760	283	19	.	.	PUNCT
ajmsi-1760	283	20	features	feature	NOUN
ajmsi-1760	283	21	of	of	ADP
ajmsi-1760	283	22	kidney	kidney	NOUN
ajmsi-1760	283	23	damage	damage	NOUN
ajmsi-1760	283	24	in	in	ADP
ajmsi-1760	283	25	patients	patient	NOUN
ajmsi-1760	283	26	with	with	ADP
ajmsi-1760	283	27	diabetes	diabetes	NOUN
ajmsi-1760	283	28	mellitus	mellitus	NOUN
ajmsi-1760	283	29	type	type	VERB
ajmsi-1760	283	30	2	2	NUM
ajmsi-1760	283	31	and	and	CCONJ
ajmsi-1760	283	32	essential	essential	ADJ
ajmsi-1760	283	33	hypertension	hypertension	NOUN
ajmsi-1760	283	34	.	.	PUNCT
ajmsi-1760	284	1	journal	journal	NOUN
ajmsi-1760	284	2	of	of	ADP
ajmsi-1760	284	3	86th	86th	ADJ
ajmsi-1760	284	4	scientific	scientific	ADJ
ajmsi-1760	284	5	and	and	CCONJ
ajmsi-1760	284	6	practical	practical	ADJ
ajmsi-1760	284	7	conference	conference	NOUN
ajmsi-1760	284	8	of	of	ADP
ajmsi-1760	284	9	students	student	NOUN
ajmsi-1760	284	10	and	and	CCONJ
ajmsi-1760	284	11	young	young	ADJ
ajmsi-1760	284	12	scientists	scientist	NOUN
ajmsi-1760	284	13	with	with	ADP
ajmsi-1760	284	14	international	international	ADJ
ajmsi-1760	284	15	participation	participation	NOUN
ajmsi-1760	284	16	“	"	PUNCT
ajmsi-1760	284	17	innovations	innovation	NOUN
ajmsi-1760	284	18	in	in	ADP
ajmsi-1760	284	19	medicine	medicine	NOUN
ajmsi-1760	284	20	”	"	PUNCT
ajmsi-1760	284	21	,	,	PUNCT
ajmsi-1760	284	22	p.	p.	NOUN
ajmsi-1760	284	23	144	144	NUM
ajmsi-1760	284	24	.	.	PUNCT
ajmsi-1760	285	1	available	available	ADJ
ajmsi-1760	285	2	online	online	ADV
ajmsi-1760	285	3	:	:	PUNCT
ajmsi-1760	285	4	http://www.ifnmu.edu.ua/images/	http://www.ifnmu.edu.ua/images/	NOUN
ajmsi-1760	285	5	snt/86	snt/86	NOUN
ajmsi-1760	285	6	-	-	PUNCT
ajmsi-1760	285	7	konf	konf	NOUN
ajmsi-1760	285	8	-	-	PUNCT
ajmsi-1760	285	9	tezi%20(1).pdf	tezi%20(1).pdf	PROPN
ajmsi-1760	285	10	ikwuka	ikwuka	NOUN
ajmsi-1760	285	11	,	,	PUNCT
ajmsi-1760	285	12	a.	a.	NOUN
ajmsi-1760	285	13	o.	o.	PROPN
ajmsi-1760	285	14	,	,	PUNCT
ajmsi-1760	285	15	virstyuk	virstyuk	NOUN
ajmsi-1760	285	16	,	,	PUNCT
ajmsi-1760	285	17	n.	n.	PROPN
ajmsi-1760	285	18	g.	g.	PROPN
ajmsi-1760	285	19	&	&	CCONJ
ajmsi-1760	285	20	luchko	luchko	PROPN
ajmsi-1760	285	21	,	,	PUNCT
ajmsi-1760	285	22	o.	o.	PROPN
ajmsi-1760	285	23	r.	r.	PROPN
ajmsi-1760	285	24	(	(	PUNCT
ajmsi-1760	285	25	2017)e	2017)e	NUM
ajmsi-1760	285	26	.	.	PUNCT
ajmsi-1760	286	1	features	feature	NOUN
ajmsi-1760	286	2	of	of	ADP
ajmsi-1760	286	3	the	the	DET
ajmsi-1760	286	4	functional	functional	ADJ
ajmsi-1760	286	5	state	state	NOUN
ajmsi-1760	286	6	of	of	ADP
ajmsi-1760	286	7	kidneys	kidney	NOUN
ajmsi-1760	286	8	in	in	ADP
ajmsi-1760	286	9	patients	patient	NOUN
ajmsi-1760	286	10	with	with	ADP
ajmsi-1760	286	11	diabetes	diabetes	NOUN
ajmsi-1760	286	12	mellitus	mellitus	NOUN
ajmsi-1760	286	13	type	type	VERB
ajmsi-1760	286	14	2	2	NUM
ajmsi-1760	286	15	and	and	CCONJ
ajmsi-1760	286	16	essential	essential	ADJ
ajmsi-1760	286	17	arterial	arterial	ADJ
ajmsi-1760	286	18	hypertension	hypertension	NOUN
ajmsi-1760	286	19	.	.	PUNCT
ajmsi-1760	287	1	materials	material	NOUN
ajmsi-1760	287	2	of	of	ADP
ajmsi-1760	287	3	scientific	scientific	ADJ
ajmsi-1760	287	4	-	-	PUNCT
ajmsi-1760	287	5	practical	practical	ADJ
ajmsi-1760	287	6	conference	conference	NOUN
ajmsi-1760	287	7	with	with	ADP
ajmsi-1760	287	8	international	international	ADJ
ajmsi-1760	287	9	participation	participation	NOUN
ajmsi-1760	287	10	“	"	PUNCT
ajmsi-1760	287	11	babenkivski	babenkivski	ADJ
ajmsi-1760	287	12	reading	reading	NOUN
ajmsi-1760	287	13	”	"	PUNCT
ajmsi-1760	287	14	,	,	PUNCT
ajmsi-1760	287	15	p.	p.	NOUN
ajmsi-1760	287	16	48	48	NUM
ajmsi-1760	287	17	.	.	PUNCT
ajmsi-1760	288	1	ikwuka	ikwuka	PROPN
ajmsi-1760	288	2	,	,	PUNCT
ajmsi-1760	288	3	a.	a.	NOUN
ajmsi-1760	288	4	o.	o.	PROPN
ajmsi-1760	288	5	(	(	PUNCT
ajmsi-1760	288	6	2018)a	2018)a	X
ajmsi-1760	288	7	.	.	NOUN
ajmsi-1760	288	8	clinical	clinical	ADJ
ajmsi-1760	288	9	dynamics	dynamic	NOUN
ajmsi-1760	288	10	in	in	ADP
ajmsi-1760	288	11	patients	patient	NOUN
ajmsi-1760	288	12	with	with	ADP
ajmsi-1760	288	13	diabetes	diabetes	NOUN
ajmsi-1760	288	14	mellitus	mellitus	NOUN
ajmsi-1760	288	15	type	type	VERB
ajmsi-1760	288	16	2	2	NUM
ajmsi-1760	288	17	and	and	CCONJ
ajmsi-1760	288	18	concomitant	concomitant	ADJ
ajmsi-1760	288	19	essential	essential	ADJ
ajmsi-1760	288	20	hypertensive	hypertensive	ADJ
ajmsi-1760	288	21	disease	disease	NOUN
ajmsi-1760	288	22	treated	treat	VERB
ajmsi-1760	288	23	with	with	ADP
ajmsi-1760	288	24	dapagliflozin	dapagliflozin	PROPN
ajmsi-1760	288	25	.	.	PUNCT
ajmsi-1760	289	1	journal	journal	PROPN
ajmsi-1760	289	2	of	of	ADP
ajmsi-1760	289	3	the	the	DET
ajmsi-1760	289	4	22nd	22nd	ADJ
ajmsi-1760	289	5	international	international	PROPN
ajmsi-1760	289	6	medical	medical	ADJ
ajmsi-1760	289	7	congress	congress	PROPN
ajmsi-1760	289	8	of	of	ADP
ajmsi-1760	289	9	students	student	NOUN
ajmsi-1760	289	10	and	and	CCONJ
ajmsi-1760	289	11	young	young	ADJ
ajmsi-1760	289	12	scientists	scientist	NOUN
ajmsi-1760	289	13	,	,	PUNCT
ajmsi-1760	289	14	p.	p.	NOUN
ajmsi-1760	289	15	32	32	NUM
ajmsi-1760	289	16	.	.	PUNCT
ajmsi-1760	290	1	ikwuka	ikwuka	PROPN
ajmsi-1760	290	2	,	,	PUNCT
ajmsi-1760	290	3	a.	a.	NOUN
ajmsi-1760	290	4	o.	o.	PROPN
ajmsi-1760	290	5	(	(	PUNCT
ajmsi-1760	290	6	2018)b	2018)b	X
ajmsi-1760	290	7	.	.	PUNCT
ajmsi-1760	291	1	clinical	clinical	ADJ
ajmsi-1760	291	2	effectiveness	effectiveness	NOUN
ajmsi-1760	291	3	of	of	ADP
ajmsi-1760	291	4	sglt-2	sglt-2	NUM
ajmsi-1760	291	5	inhibitors	inhibitor	NOUN
ajmsi-1760	291	6	in	in	ADP
ajmsi-1760	291	7	patients	patient	NOUN
ajmsi-1760	291	8	with	with	ADP
ajmsi-1760	291	9	diabetes	diabetes	NOUN
ajmsi-1760	291	10	mellitus	mellitus	NOUN
ajmsi-1760	291	11	type	type	VERB
ajmsi-1760	291	12	2	2	NUM
ajmsi-1760	291	13	and	and	CCONJ
ajmsi-1760	291	14	essential	essential	ADJ
ajmsi-1760	291	15	hypertensive	hypertensive	ADJ
ajmsi-1760	291	16	disease	disease	NOUN
ajmsi-1760	291	17	.	.	PUNCT
ajmsi-1760	292	1	endocrine	endocrine	ADJ
ajmsi-1760	292	2	practice	practice	NOUN
ajmsi-1760	292	3	,	,	PUNCT
ajmsi-1760	292	4	24(1	24(1	NUM
ajmsi-1760	292	5	)	)	PUNCT
ajmsi-1760	292	6	,	,	PUNCT
ajmsi-1760	292	7	74	74	NUM
ajmsi-1760	292	8	.	.	PUNCT
ajmsi-1760	293	1	https://doi.org/10.1016/s1530-891x(20)47129-0	https://doi.org/10.1016/s1530-891x(20)47129-0	PROPN
ajmsi-1760	293	2	.	.	PUNCT
ajmsi-1760	294	1	ikwuka	ikwuka	PROPN
ajmsi-1760	294	2	,	,	PUNCT
ajmsi-1760	294	3	a.	a.	NOUN
ajmsi-1760	294	4	o.	o.	PROPN
ajmsi-1760	294	5	(	(	PUNCT
ajmsi-1760	294	6	2018)c	2018)c	NUM
ajmsi-1760	294	7	.	.	PUNCT
ajmsi-1760	295	1	features	feature	NOUN
ajmsi-1760	295	2	of	of	ADP
ajmsi-1760	295	3	kidney	kidney	NOUN
ajmsi-1760	295	4	damage	damage	NOUN
ajmsi-1760	295	5	in	in	ADP
ajmsi-1760	295	6	patients	patient	NOUN
ajmsi-1760	295	7	with	with	ADP
ajmsi-1760	295	8	arterial	arterial	ADJ
ajmsi-1760	295	9	hypertension	hypertension	NOUN
ajmsi-1760	295	10	and	and	CCONJ
ajmsi-1760	295	11	type	type	NOUN
ajmsi-1760	295	12	2	2	NUM
ajmsi-1760	295	13	diabetes	diabetes	NOUN
ajmsi-1760	295	14	mellitus	mellitus	NOUN
ajmsi-1760	295	15	and	and	CCONJ
ajmsi-1760	295	16	optimization	optimization	NOUN
ajmsi-1760	295	17	of	of	ADP
ajmsi-1760	295	18	treatment	treatment	NOUN
ajmsi-1760	295	19	.	.	PUNCT
ajmsi-1760	296	1	specialized	specialized	ADJ
ajmsi-1760	296	2	academic	academic	ADJ
ajmsi-1760	296	3	council	council	PROPN
ajmsi-1760	296	4	ifnmu	ifnmu	NOUN
ajmsi-1760	296	5	,	,	PUNCT
ajmsi-1760	296	6	available	available	ADJ
ajmsi-1760	296	7	online	online	ADV
ajmsi-1760	296	8	:	:	PUNCT
ajmsi-1760	296	9	http://	http://	NUM
ajmsi-1760	296	10	www.ifnmu.edu.ua/images/zagalna_informacia/spec	www.ifnmu.edu.ua/images/zagalna_informacia/spec	NOUN
ajmsi-1760	296	11	_	_	PUNCT
ajmsi-1760	296	12	vcheni_radi/2017	vcheni_radi/2017	PROPN
ajmsi-1760	296	13	-	-	PUNCT
ajmsi-1760	296	14	2019/%d0%9420.601.01	2019/%d0%9420.601.01	NUM
ajmsi-1760	296	15	/	/	SYM
ajmsi-1760	296	16	ikvuka/	ikvuka/	NUM
ajmsi-1760	296	17	avtoreferat.pdf	avtoreferat.pdf	X
ajmsi-1760	296	18	ikwuka	ikwuka	VERB
ajmsi-1760	296	19	,	,	PUNCT
ajmsi-1760	296	20	a.	a.	NOUN
ajmsi-1760	296	21	o.	o.	PROPN
ajmsi-1760	296	22	&	&	CCONJ
ajmsi-1760	296	23	paliy	paliy	PROPN
ajmsi-1760	296	24	,	,	PUNCT
ajmsi-1760	296	25	yu	yu	PROPN
ajmsi-1760	296	26	.	.	PUNCT
ajmsi-1760	296	27	(	(	PUNCT
ajmsi-1760	296	28	2018)d	2018)d	NUM
ajmsi-1760	296	29	.	.	PUNCT
ajmsi-1760	296	30	structural	structural	ADJ
ajmsi-1760	296	31	changes	change	NOUN
ajmsi-1760	296	32	of	of	ADP
ajmsi-1760	296	33	the	the	DET
ajmsi-1760	296	34	left	left	ADJ
ajmsi-1760	296	35	ventricular	ventricular	ADJ
ajmsi-1760	296	36	myocardium	myocardium	NOUN
ajmsi-1760	296	37	in	in	ADP
ajmsi-1760	296	38	patients	patient	NOUN
ajmsi-1760	296	39	with	with	ADP
ajmsi-1760	296	40	essential	essential	ADJ
ajmsi-1760	296	41	arterial	arterial	ADJ
ajmsi-1760	296	42	hypertension	hypertension	NOUN
ajmsi-1760	296	43	and	and	CCONJ
ajmsi-1760	296	44	diabetes	diabetes	NOUN
ajmsi-1760	296	45	mellitus	mellitus	NOUN
ajmsi-1760	296	46	type	type	VERB
ajmsi-1760	296	47	2	2	NUM
ajmsi-1760	296	48	.	.	PUNCT
ajmsi-1760	296	49	abstracts	abstract	NOUN
ajmsi-1760	296	50	of	of	ADP
ajmsi-1760	296	51	the	the	DET
ajmsi-1760	296	52	87th	87th	ADJ
ajmsi-1760	296	53	scientific	scientific	ADJ
ajmsi-1760	296	54	conference	conference	NOUN
ajmsi-1760	296	55	of	of	ADP
ajmsi-1760	296	56	students	student	NOUN
ajmsi-1760	296	57	and	and	CCONJ
ajmsi-1760	296	58	young	young	ADJ
ajmsi-1760	296	59	scientists	scientist	NOUN
ajmsi-1760	296	60	with	with	ADP
ajmsi-1760	296	61	international	international	ADJ
ajmsi-1760	296	62	participation	participation	NOUN
ajmsi-1760	296	63	“	"	PUNCT
ajmsi-1760	296	64	innovations	innovation	NOUN
ajmsi-1760	296	65	in	in	ADP
ajmsi-1760	296	66	medicine	medicine	NOUN
ajmsi-1760	296	67	”	"	PUNCT
ajmsi-1760	296	68	,	,	PUNCT
ajmsi-1760	296	69	p.	p.	NOUN
ajmsi-1760	296	70	25	25	NUM
ajmsi-1760	296	71	-	-	SYM
ajmsi-1760	296	72	26	26	NUM
ajmsi-1760	296	73	.	.	PUNCT
ajmsi-1760	297	1	available	available	ADJ
ajmsi-1760	297	2	online	online	ADV
ajmsi-1760	297	3	:	:	PUNCT
ajmsi-1760	298	1	https://www	https://www	PROPN
ajmsi-1760	298	2	.	.	PUNCT
ajmsi-1760	298	3	ifnmu.edu.ua/images/snt/zaproshennia_eng.pdf	ifnmu.edu.ua/images/snt/zaproshennia_eng.pdf	PROPN
ajmsi-1760	298	4	ikwuka	ikwuka	PROPN
ajmsi-1760	298	5	,	,	PUNCT
ajmsi-1760	298	6	a.	a.	NOUN
ajmsi-1760	298	7	o.	o.	PROPN
ajmsi-1760	298	8	(	(	PUNCT
ajmsi-1760	298	9	2019)a	2019)a	NUM
ajmsi-1760	298	10	.	.	NOUN
ajmsi-1760	298	11	clinical	clinical	ADJ
ajmsi-1760	298	12	dynamics	dynamic	NOUN
ajmsi-1760	298	13	of	of	ADP
ajmsi-1760	298	14	nephropathy	nephropathy	NOUN
ajmsi-1760	298	15	in	in	ADP
ajmsi-1760	298	16	patients	patient	NOUN
ajmsi-1760	298	17	with	with	ADP
ajmsi-1760	298	18	diabetes	diabetes	NOUN
ajmsi-1760	298	19	mellitus	mellitus	NOUN
ajmsi-1760	298	20	type	type	VERB
ajmsi-1760	298	21	2	2	NUM
ajmsi-1760	298	22	and	and	CCONJ
ajmsi-1760	298	23	concomitant	concomitant	ADJ
ajmsi-1760	298	24	essential	essential	ADJ
ajmsi-1760	298	25	hypertensive	hypertensive	ADJ
ajmsi-1760	298	26	disease	disease	NOUN
ajmsi-1760	298	27	.	.	PUNCT
ajmsi-1760	299	1	clinical	clinical	ADJ
ajmsi-1760	299	2	medicine	medicine	NOUN
ajmsi-1760	299	3	,	,	PUNCT
ajmsi-1760	299	4	19(2	19(2	NUM
ajmsi-1760	299	5	)	)	PUNCT
ajmsi-1760	299	6	,	,	PUNCT
ajmsi-1760	299	7	s39	s39	PROPN
ajmsi-1760	299	8	.	.	PUNCT
ajmsi-1760	300	1	https://doi.org/10.7861/clinmedicine.19-2-s39	https://doi.org/10.7861/clinmedicine.19-2-s39	PROPN
ajmsi-1760	300	2	.	.	PUNCT
ajmsi-1760	301	1	ikwuka	ikwuka	PROPN
ajmsi-1760	301	2	,	,	PUNCT
ajmsi-1760	301	3	a.	a.	NOUN
ajmsi-1760	301	4	o.	o.	PROPN
ajmsi-1760	301	5	(	(	PUNCT
ajmsi-1760	301	6	2019)b	2019)b	NUM
ajmsi-1760	301	7	.	.	PUNCT
ajmsi-1760	301	8	clinical	clinical	ADJ
ajmsi-1760	301	9	effectiveness	effectiveness	NOUN
ajmsi-1760	301	10	of	of	ADP
ajmsi-1760	301	11	glp-1	glp-1	NOUN
ajmsi-1760	301	12	ras	ras	X
ajmsi-1760	301	13	in	in	ADP
ajmsi-1760	301	14	patients	patient	NOUN
ajmsi-1760	301	15	with	with	ADP
ajmsi-1760	301	16	metabolic	metabolic	NOUN
ajmsi-1760	301	17	syndrome	syndrome	NOUN
ajmsi-1760	301	18	diseases	disease	NOUN
ajmsi-1760	301	19	.	.	PUNCT
ajmsi-1760	302	1	endocrine	endocrine	ADJ
ajmsi-1760	302	2	practice	practice	NOUN
ajmsi-1760	302	3	,	,	PUNCT
ajmsi-1760	302	4	25(1	25(1	NUM
ajmsi-1760	302	5	)	)	PUNCT
ajmsi-1760	302	6	,	,	PUNCT
ajmsi-1760	302	7	104	104	NUM
ajmsi-1760	302	8	-	-	SYM
ajmsi-1760	302	9	105	105	NUM
ajmsi-1760	302	10	.	.	PUNCT
ajmsi-1760	303	1	https://doi.org/10.1016/	https://doi.org/10.1016/	PROPN
ajmsi-1760	303	2	s1530	s1530	NUM
ajmsi-1760	303	3	-	-	PUNCT
ajmsi-1760	303	4	891x(20)46611	891x(20)46611	NOUN
ajmsi-1760	303	5	-	-	PUNCT
ajmsi-1760	303	6	x.	x.	NOUN
ajmsi-1760	303	7	ikwuka	ikwuka	PROPN
ajmsi-1760	303	8	,	,	PUNCT
ajmsi-1760	303	9	a.	a.	PROPN
ajmsi-1760	303	10	o.	o.	PROPN
ajmsi-1760	303	11	&	&	CCONJ
ajmsi-1760	303	12	virstyuk	virstyuk	PROPN
ajmsi-1760	303	13	,	,	PUNCT
ajmsi-1760	303	14	n.	n.	PROPN
ajmsi-1760	303	15	g.	g.	PROPN
ajmsi-1760	303	16	(	(	PUNCT
ajmsi-1760	303	17	2019)c	2019)c	NUM
ajmsi-1760	303	18	.	.	PUNCT
ajmsi-1760	303	19	pattern	pattern	NOUN
ajmsi-1760	303	20	of	of	ADP
ajmsi-1760	303	21	cardiac	cardiac	ADJ
ajmsi-1760	303	22	remodelling	remodelling	NOUN
ajmsi-1760	303	23	of	of	ADP
ajmsi-1760	303	24	the	the	DET
ajmsi-1760	303	25	left	left	ADJ
ajmsi-1760	303	26	ventricle	ventricle	NOUN
ajmsi-1760	303	27	in	in	ADP
ajmsi-1760	303	28	patients	patient	NOUN
ajmsi-1760	303	29	with	with	ADP
ajmsi-1760	303	30	essential	essential	ADJ
ajmsi-1760	303	31	hypertensive	hypertensive	ADJ
ajmsi-1760	303	32	disease	disease	NOUN
ajmsi-1760	303	33	and	and	CCONJ
ajmsi-1760	303	34	concomitant	concomitant	ADJ
ajmsi-1760	303	35	type	type	NOUN
ajmsi-1760	303	36	2	2	NUM
ajmsi-1760	303	37	diabetes	diabetes	NOUN
ajmsi-1760	303	38	mellitus	mellitus	NOUN
ajmsi-1760	303	39	.	.	PUNCT
ajmsi-1760	304	1	clinical	clinical	ADJ
ajmsi-1760	304	2	medicine	medicine	NOUN
ajmsi-1760	304	3	,	,	PUNCT
ajmsi-1760	304	4	19(3	19(3	NUM
ajmsi-1760	304	5	)	)	PUNCT
ajmsi-1760	304	6	,	,	PUNCT
ajmsi-1760	304	7	s92	s92	NOUN
ajmsi-1760	304	8	.	.	PUNCT
ajmsi-1760	305	1	https://	https://	PROPN
ajmsi-1760	305	2	doi.org/10.7861/clinmedicine.19-3-s92	doi.org/10.7861/clinmedicine.19-3-s92	PROPN
ajmsi-1760	305	3	.	.	PROPN
ajmsi-1760	305	4	ikwuka	ikwuka	PROPN
ajmsi-1760	305	5	,	,	PUNCT
ajmsi-1760	305	6	a.	a.	PROPN
ajmsi-1760	305	7	o.	o.	PROPN
ajmsi-1760	305	8	&	&	CCONJ
ajmsi-1760	305	9	virstyuk	virstyuk	PROPN
ajmsi-1760	305	10	,	,	PUNCT
ajmsi-1760	305	11	n.	n.	NOUN
ajmsi-1760	305	12	g.	g.	PROPN
ajmsi-1760	305	13	(	(	PUNCT
ajmsi-1760	305	14	2021	2021	NUM
ajmsi-1760	305	15	)	)	PUNCT
ajmsi-1760	305	16	.	.	PUNCT
ajmsi-1760	306	1	influence	influence	NOUN
ajmsi-1760	306	2	of	of	ADP
ajmsi-1760	306	3	sglt2	sglt2	ADJ
ajmsi-1760	306	4	inhibitor	inhibitor	NOUN
ajmsi-1760	306	5	and	and	CCONJ
ajmsi-1760	306	6	a2rb	a2rb	PUNCT
ajmsi-1760	306	7	(	(	PUNCT
ajmsi-1760	306	8	at1	at1	PROPN
ajmsi-1760	306	9	)	)	PUNCT
ajmsi-1760	306	10	on	on	ADP
ajmsi-1760	306	11	fibrogenesis	fibrogenesis	ADJ
ajmsi-1760	306	12	and	and	CCONJ
ajmsi-1760	306	13	heart	heart	NOUN
ajmsi-1760	306	14	failure	failure	NOUN
ajmsi-1760	306	15	in	in	ADP
ajmsi-1760	306	16	patients	patient	NOUN
ajmsi-1760	306	17	with	with	ADP
ajmsi-1760	306	18	essential	essential	ADJ
ajmsi-1760	306	19	hypertensive	hypertensive	ADJ
ajmsi-1760	306	20	disease	disease	NOUN
ajmsi-1760	306	21	combined	combine	VERB
ajmsi-1760	306	22	with	with	ADP
ajmsi-1760	306	23	diabetes	diabetes	NOUN
ajmsi-1760	306	24	mellitus	mellitus	NOUN
ajmsi-1760	306	25	type	type	VERB
ajmsi-1760	306	26	2	2	NUM
ajmsi-1760	306	27	.	.	PUNCT
ajmsi-1760	307	1	e	e	X
ajmsi-1760	307	2	-	-	NOUN
ajmsi-1760	307	3	poster	poster	NOUN
ajmsi-1760	307	4	no	no	INTJ
ajmsi-1760	307	5	.	.	NOUN
ajmsi-1760	308	1	143	143	NUM
ajmsi-1760	308	2	of	of	ADP
ajmsi-1760	308	3	the	the	DET
ajmsi-1760	308	4	44th	44th	ADJ
ajmsi-1760	308	5	&	&	CCONJ
ajmsi-1760	308	6	45th	45th	ADJ
ajmsi-1760	308	7	annual	annual	ADJ
ajmsi-1760	308	8	general	general	ADJ
ajmsi-1760	308	9	and	and	CCONJ
ajmsi-1760	308	10	scientific	scientific	ADJ
ajmsi-1760	308	11	meeting	meeting	NOUN
ajmsi-1760	308	12	of	of	ADP
ajmsi-1760	308	13	the	the	DET
ajmsi-1760	308	14	west	west	PROPN
ajmsi-1760	308	15	african	african	PROPN
ajmsi-1760	308	16	college	college	PROPN
ajmsi-1760	308	17	of	of	ADP
ajmsi-1760	308	18	physicians	physician	NOUN
ajmsi-1760	308	19	(	(	PUNCT
ajmsi-1760	308	20	wacp	wacp	PROPN
ajmsi-1760	308	21	)	)	PUNCT
ajmsi-1760	308	22	,	,	PUNCT
ajmsi-1760	308	23	1	1	NUM
ajmsi-1760	308	24	3	3	NUM
ajmsi-1760	308	25	november	november	PROPN
ajmsi-1760	308	26	,	,	PUNCT
ajmsi-1760	308	27	2021	2021	NUM
ajmsi-1760	308	28	.	.	PUNCT
ajmsi-1760	309	1	https://doi.org/10.13140/	https://doi.org/10.13140/	PROPN
ajmsi-1760	309	2	rg.2.2.26912.87047	rg.2.2.26912.87047	PROPN
ajmsi-1760	309	3	.	.	PUNCT
ajmsi-1760	309	4	ikwuka	ikwuka	PROPN
ajmsi-1760	309	5	,	,	PUNCT
ajmsi-1760	309	6	a.	a.	PROPN
ajmsi-1760	309	7	o.	o.	PROPN
ajmsi-1760	309	8	&	&	CCONJ
ajmsi-1760	309	9	virstyuk	virstyuk	PROPN
ajmsi-1760	309	10	,	,	PUNCT
ajmsi-1760	309	11	n.	n.	NOUN
ajmsi-1760	309	12	(	(	PUNCT
ajmsi-1760	309	13	2022	2022	NUM
ajmsi-1760	309	14	)	)	PUNCT
ajmsi-1760	309	15	.	.	PUNCT
ajmsi-1760	310	1	prognostic	prognostic	ADJ
ajmsi-1760	310	2	markers	marker	NOUN
ajmsi-1760	310	3	of	of	ADP
ajmsi-1760	310	4	nephropathy	nephropathy	NOUN
ajmsi-1760	310	5	in	in	ADP
ajmsi-1760	310	6	patients	patient	NOUN
ajmsi-1760	310	7	with	with	ADP
ajmsi-1760	310	8	dual	dual	ADJ
ajmsi-1760	310	9	metabolic	metabolic	NOUN
ajmsi-1760	310	10	syndrome	syndrome	NOUN
ajmsi-1760	310	11	diseases	disease	NOUN
ajmsi-1760	310	12	(	(	PUNCT
ajmsi-1760	310	13	essential	essential	ADJ
ajmsi-1760	310	14	hypertensive	hypertensive	ADJ
ajmsi-1760	310	15	disease	disease	NOUN
ajmsi-1760	310	16	and	and	CCONJ
ajmsi-1760	310	17	concomitant	concomitant	ADJ
ajmsi-1760	310	18	type	type	NOUN
ajmsi-1760	310	19	2	2	NUM
ajmsi-1760	310	20	diabetes	diabetes	NOUN
ajmsi-1760	310	21	mellitus	mellitus	NOUN
ajmsi-1760	310	22	)	)	PUNCT
ajmsi-1760	310	23	.	.	PUNCT
ajmsi-1760	311	1	endocrine	endocrine	ADJ
ajmsi-1760	311	2	practice	practice	NOUN
ajmsi-1760	311	3	,	,	PUNCT
ajmsi-1760	311	4	28(5	28(5	NUM
ajmsi-1760	311	5	)	)	PUNCT
ajmsi-1760	311	6	,	,	PUNCT
ajmsi-1760	311	7	s65	s65	NOUN
ajmsi-1760	311	8	-	-	PUNCT
ajmsi-1760	311	9	s66	s66	NOUN
ajmsi-1760	311	10	.	.	PUNCT
ajmsi-1760	312	1	https://doi.org/10.1016/j	https://doi.org/10.1016/j	NOUN
ajmsi-1760	312	2	.	.	PUNCT
ajmsi-1760	313	1	eprac.2022.03.164	eprac.2022.03.164	NOUN
ajmsi-1760	313	2	.	.	PUNCT
ajmsi-1760	314	1	ikwuka	ikwuka	PROPN
ajmsi-1760	314	2	,	,	PUNCT
ajmsi-1760	314	3	a.	a.	NOUN
ajmsi-1760	314	4	o.	o.	PROPN
ajmsi-1760	314	5	(	(	PUNCT
ajmsi-1760	314	6	2023)a	2023)a	NUM
ajmsi-1760	314	7	.	.	X
ajmsi-1760	315	1	dr	dr	PROPN
ajmsi-1760	315	2	.	.	PROPN
ajmsi-1760	315	3	aloy	aloy	PROPN
ajmsi-1760	315	4	’s	’s	PART
ajmsi-1760	315	5	core	core	ADJ
ajmsi-1760	315	6	essential	essential	ADJ
ajmsi-1760	315	7	series	series	NOUN
ajmsi-1760	315	8	(	(	PUNCT
ajmsi-1760	315	9	daces	dace	NOUN
ajmsi-1760	315	10	)	)	PUNCT
ajmsi-1760	315	11	medical	medical	ADJ
ajmsi-1760	315	12	genetics	genetic	NOUN
ajmsi-1760	315	13	.	.	PUNCT
ajmsi-1760	316	1	1st	1st	PROPN
ajmsi-1760	316	2	edition	edition	PROPN
ajmsi-1760	316	3	.	.	PUNCT
ajmsi-1760	317	1	science	science	NOUN
ajmsi-1760	317	2	and	and	CCONJ
ajmsi-1760	317	3	education	education	NOUN
ajmsi-1760	317	4	publishing	publishing	NOUN
ajmsi-1760	317	5	,	,	PUNCT
ajmsi-1760	317	6	usa	usa	PROPN
ajmsi-1760	317	7	,	,	PUNCT
ajmsi-1760	317	8	p.	p.	NOUN
ajmsi-1760	317	9	1	1	NUM
ajmsi-1760	317	10	.	.	PUNCT
ajmsi-1760	318	1	pa	pa	PROPN
ajmsi-1760	318	2	ge	ge	PROPN
ajmsi-1760	318	3	55	55	NUM
ajmsi-1760	318	4	https://journals.e-palli.com/home/index.php/ajmsi	https://journals.e-palli.com/home/index.php/ajmsi	NOUN
ajmsi-1760	318	5	am	be	AUX
ajmsi-1760	318	6	.	.	PUNCT
ajmsi-1760	319	1	j.	j.	PROPN
ajmsi-1760	319	2	med	med	PROPN
ajmsi-1760	319	3	.	.	PUNCT
ajmsi-1760	320	1	sci	sci	PROPN
ajmsi-1760	320	2	.	.	PUNCT
ajmsi-1760	320	3	innov	innov	PROPN
ajmsi-1760	320	4	.	.	PUNCT
ajmsi-1760	321	1	2(2	2(2	NUM
ajmsi-1760	321	2	)	)	PUNCT
ajmsi-1760	321	3	44	44	NUM
ajmsi-1760	321	4	-	-	SYM
ajmsi-1760	321	5	56	56	NUM
ajmsi-1760	321	6	,	,	PUNCT
ajmsi-1760	321	7	2023	2023	NUM
ajmsi-1760	321	8	ikwuka	ikwuka	NOUN
ajmsi-1760	321	9	,	,	PUNCT
ajmsi-1760	322	1	a.	a.	NOUN
ajmsi-1760	322	2	o.	o.	PROPN
ajmsi-1760	322	3	(	(	PUNCT
ajmsi-1760	322	4	2023)b	2023)b	NUM
ajmsi-1760	322	5	.	.	PUNCT
ajmsi-1760	323	1	dr	dr	PROPN
ajmsi-1760	323	2	.	.	PROPN
ajmsi-1760	323	3	aloy	aloy	PROPN
ajmsi-1760	323	4	’s	’s	PART
ajmsi-1760	323	5	core	core	ADJ
ajmsi-1760	323	6	essential	essential	ADJ
ajmsi-1760	323	7	series	series	NOUN
ajmsi-1760	323	8	(	(	PUNCT
ajmsi-1760	323	9	daces	dace	NOUN
ajmsi-1760	323	10	)	)	PUNCT
ajmsi-1760	323	11	medical	medical	ADJ
ajmsi-1760	323	12	genetics	genetic	NOUN
ajmsi-1760	323	13	.	.	PUNCT
ajmsi-1760	324	1	1st	1st	PROPN
ajmsi-1760	324	2	edition	edition	PROPN
ajmsi-1760	324	3	.	.	PUNCT
ajmsi-1760	325	1	science	science	NOUN
ajmsi-1760	325	2	and	and	CCONJ
ajmsi-1760	325	3	education	education	NOUN
ajmsi-1760	325	4	publishing	publishing	NOUN
ajmsi-1760	325	5	,	,	PUNCT
ajmsi-1760	325	6	usa	usa	PROPN
ajmsi-1760	325	7	,	,	PUNCT
ajmsi-1760	325	8	p.	p.	NOUN
ajmsi-1760	325	9	20	20	NUM
ajmsi-1760	325	10	-	-	SYM
ajmsi-1760	325	11	27	27	NUM
ajmsi-1760	325	12	.	.	PUNCT
ajmsi-1760	326	1	ikwuka	ikwuka	PROPN
ajmsi-1760	326	2	,	,	PUNCT
ajmsi-1760	326	3	a.	a.	NOUN
ajmsi-1760	326	4	o.	o.	PROPN
ajmsi-1760	326	5	(	(	PUNCT
ajmsi-1760	326	6	2023)c	2023)c	NUM
ajmsi-1760	326	7	.	.	PUNCT
ajmsi-1760	327	1	dr	dr	PROPN
ajmsi-1760	327	2	.	.	PROPN
ajmsi-1760	327	3	aloy	aloy	PROPN
ajmsi-1760	327	4	’s	’s	PART
ajmsi-1760	327	5	core	core	ADJ
ajmsi-1760	327	6	essential	essential	ADJ
ajmsi-1760	327	7	series	series	NOUN
ajmsi-1760	327	8	(	(	PUNCT
ajmsi-1760	327	9	daces	dace	NOUN
ajmsi-1760	327	10	)	)	PUNCT
ajmsi-1760	327	11	immunology	immunology	NOUN
ajmsi-1760	327	12	.	.	PUNCT
ajmsi-1760	328	1	1st	1st	PROPN
ajmsi-1760	328	2	edition	edition	PROPN
ajmsi-1760	328	3	.	.	PUNCT
ajmsi-1760	329	1	science	science	NOUN
ajmsi-1760	329	2	and	and	CCONJ
ajmsi-1760	329	3	education	education	NOUN
ajmsi-1760	329	4	publishing	publishing	NOUN
ajmsi-1760	329	5	,	,	PUNCT
ajmsi-1760	329	6	usa	usa	PROPN
ajmsi-1760	329	7	,	,	PUNCT
ajmsi-1760	329	8	p.	p.	NOUN
ajmsi-1760	329	9	31	31	NUM
ajmsi-1760	329	10	.	.	PUNCT
ajmsi-1760	330	1	ikwuka	ikwuka	PROPN
ajmsi-1760	330	2	,	,	PUNCT
ajmsi-1760	330	3	a.	a.	PROPN
ajmsi-1760	330	4	o.	o.	PROPN
ajmsi-1760	330	5	&	&	CCONJ
ajmsi-1760	330	6	virstyuk	virstyuk	PROPN
ajmsi-1760	330	7	,	,	PUNCT
ajmsi-1760	330	8	n.	n.	NOUN
ajmsi-1760	330	9	(	(	PUNCT
ajmsi-1760	330	10	2023)d	2023)d	NOUN
ajmsi-1760	330	11	.	.	NOUN
ajmsi-1760	330	12	patterns	pattern	NOUN
ajmsi-1760	330	13	and	and	CCONJ
ajmsi-1760	330	14	influence	influence	NOUN
ajmsi-1760	330	15	of	of	ADP
ajmsi-1760	330	16	cardio	cardio	NOUN
ajmsi-1760	330	17	-	-	PUNCT
ajmsi-1760	330	18	metabolic	metabolic	NOUN
ajmsi-1760	330	19	insufficiency	insufficiency	NOUN
ajmsi-1760	330	20	in	in	ADP
ajmsi-1760	330	21	patients	patient	NOUN
ajmsi-1760	330	22	with	with	ADP
ajmsi-1760	330	23	essential	essential	ADJ
ajmsi-1760	330	24	hypertensive	hypertensive	ADJ
ajmsi-1760	330	25	disease	disease	NOUN
ajmsi-1760	330	26	and	and	CCONJ
ajmsi-1760	330	27	concomitant	concomitant	ADJ
ajmsi-1760	330	28	type	type	NOUN
ajmsi-1760	330	29	2	2	NUM
ajmsi-1760	330	30	diabetes	diabetes	NOUN
ajmsi-1760	330	31	mellitus	mellitus	NOUN
ajmsi-1760	330	32	.	.	PUNCT
ajmsi-1760	331	1	endocrine	endocrine	ADJ
ajmsi-1760	331	2	practice	practice	NOUN
ajmsi-1760	331	3	,	,	PUNCT
ajmsi-1760	331	4	29(5	29(5	NUM
ajmsi-1760	331	5	)	)	PUNCT
ajmsi-1760	331	6	,	,	PUNCT
ajmsi-1760	331	7	s32	s32	PROPN
ajmsi-1760	331	8	-	-	PUNCT
ajmsi-1760	331	9	s33	s33	NOUN
ajmsi-1760	331	10	.	.	PUNCT
ajmsi-1760	332	1	https://doi.org/10.1016/j.eprac.2023.03.076	https://doi.org/10.1016/j.eprac.2023.03.076	PROPN
ajmsi-1760	332	2	.	.	PROPN
ajmsi-1760	332	3	ikwuka	ikwuka	PROPN
ajmsi-1760	332	4	,	,	PUNCT
ajmsi-1760	332	5	a.	a.	NOUN
ajmsi-1760	332	6	o.	o.	PROPN
ajmsi-1760	332	7	,	,	PUNCT
ajmsi-1760	332	8	virstyuk	virstyuk	NOUN
ajmsi-1760	332	9	,	,	PUNCT
ajmsi-1760	332	10	n.	n.	PROPN
ajmsi-1760	332	11	g.	g.	PROPN
ajmsi-1760	332	12	,	,	PUNCT
ajmsi-1760	332	13	luchko	luchko	VERB
ajmsi-1760	332	14	,	,	PUNCT
ajmsi-1760	332	15	o.	o.	PROPN
ajmsi-1760	332	16	r.	r.	PROPN
ajmsi-1760	332	17	&	&	CCONJ
ajmsi-1760	332	18	kobitovych	kobitovych	PROPN
ajmsi-1760	332	19	,	,	PUNCT
ajmsi-1760	332	20	i.	i.	PROPN
ajmsi-1760	332	21	(	(	PUNCT
ajmsi-1760	332	22	2023)e	2023)e	PROPN
ajmsi-1760	332	23	.	.	PUNCT
ajmsi-1760	332	24	heterogeneity	heterogeneity	NOUN
ajmsi-1760	332	25	of	of	ADP
ajmsi-1760	332	26	renal	renal	ADJ
ajmsi-1760	332	27	pathogenicity	pathogenicity	NOUN
ajmsi-1760	332	28	on	on	ADP
ajmsi-1760	332	29	the	the	DET
ajmsi-1760	332	30	background	background	NOUN
ajmsi-1760	332	31	of	of	ADP
ajmsi-1760	332	32	asymptomatic	asymptomatic	ADJ
ajmsi-1760	332	33	hyperuricemia	hyperuricemia	NOUN
ajmsi-1760	332	34	in	in	ADP
ajmsi-1760	332	35	patients	patient	NOUN
ajmsi-1760	332	36	with	with	ADP
ajmsi-1760	332	37	dual	dual	ADJ
ajmsi-1760	332	38	metabolic	metabolic	NOUN
ajmsi-1760	332	39	syndrome	syndrome	NOUN
ajmsi-1760	332	40	diseases	disease	NOUN
ajmsi-1760	332	41	(	(	PUNCT
ajmsi-1760	332	42	essential	essential	ADJ
ajmsi-1760	332	43	hypertensive	hypertensive	ADJ
ajmsi-1760	332	44	disease	disease	NOUN
ajmsi-1760	332	45	and	and	CCONJ
ajmsi-1760	332	46	type	type	NOUN
ajmsi-1760	332	47	2	2	NUM
ajmsi-1760	332	48	diabetes	diabetes	NOUN
ajmsi-1760	332	49	mellitus	mellitus	NOUN
ajmsi-1760	332	50	)	)	PUNCT
ajmsi-1760	332	51	.	.	PUNCT
ajmsi-1760	333	1	british	british	ADJ
ajmsi-1760	333	2	journal	journal	PROPN
ajmsi-1760	333	3	of	of	ADP
ajmsi-1760	333	4	medical	medical	ADJ
ajmsi-1760	333	5	and	and	CCONJ
ajmsi-1760	333	6	health	health	NOUN
ajmsi-1760	333	7	research	research	NOUN
ajmsi-1760	333	8	,	,	PUNCT
ajmsi-1760	333	9	10(2	10(2	NUM
ajmsi-1760	333	10	)	)	PUNCT
ajmsi-1760	333	11	,	,	PUNCT
ajmsi-1760	333	12	1	1	NUM
ajmsi-1760	333	13	-	-	SYM
ajmsi-1760	333	14	9	9	NUM
ajmsi-1760	333	15	.	.	NUM
ajmsi-1760	333	16	https://doi.org/10.5281/zenodo.7690636	https://doi.org/10.5281/zenodo.7690636	NOUN
ajmsi-1760	333	17	.	.	PUNCT
ajmsi-1760	334	1	kotagama	kotagama	PROPN
ajmsi-1760	334	2	,	,	PUNCT
ajmsi-1760	334	3	o.	o.	PROPN
ajmsi-1760	334	4	w.	w.	PROPN
ajmsi-1760	334	5	,	,	PUNCT
ajmsi-1760	334	6	jayasinghe	jayasinghe	PROPN
ajmsi-1760	334	7	,	,	PUNCT
ajmsi-1760	334	8	c.	c.	PROPN
ajmsi-1760	334	9	d.	d.	PROPN
ajmsi-1760	334	10	&	&	CCONJ
ajmsi-1760	334	11	abeysinghe	abeysinghe	PROPN
ajmsi-1760	334	12	,	,	PUNCT
ajmsi-1760	334	13	t.	t.	PROPN
ajmsi-1760	334	14	(	(	PUNCT
ajmsi-1760	334	15	2019	2019	NUM
ajmsi-1760	334	16	)	)	PUNCT
ajmsi-1760	334	17	.	.	PUNCT
ajmsi-1760	335	1	era	era	NOUN
ajmsi-1760	335	2	of	of	ADP
ajmsi-1760	335	3	genomic	genomic	ADJ
ajmsi-1760	335	4	medicine	medicine	NOUN
ajmsi-1760	335	5	:	:	PUNCT
ajmsi-1760	335	6	a	a	DET
ajmsi-1760	335	7	narrative	narrative	ADJ
ajmsi-1760	335	8	review	review	NOUN
ajmsi-1760	335	9	on	on	ADP
ajmsi-1760	335	10	crispr	crispr	ADJ
ajmsi-1760	335	11	technology	technology	NOUN
ajmsi-1760	335	12	as	as	ADP
ajmsi-1760	335	13	a	a	DET
ajmsi-1760	335	14	potential	potential	ADJ
ajmsi-1760	335	15	therapeutic	therapeutic	ADJ
ajmsi-1760	335	16	tool	tool	NOUN
ajmsi-1760	335	17	for	for	ADP
ajmsi-1760	335	18	human	human	ADJ
ajmsi-1760	335	19	diseases	disease	NOUN
ajmsi-1760	335	20	.	.	PUNCT
ajmsi-1760	335	21	biomed	biome	VERB
ajmsi-1760	335	22	research	research	NOUN
ajmsi-1760	335	23	international	international	PROPN
ajmsi-1760	335	24	,	,	PUNCT
ajmsi-1760	335	25	2019	2019	NUM
ajmsi-1760	335	26	,	,	PUNCT
ajmsi-1760	335	27	1–15	1–15	NUM
ajmsi-1760	335	28	.	.	PUNCT
ajmsi-1760	336	1	https://doi.org/10.1155/2019/1369682	https://doi.org/10.1155/2019/1369682	PROPN
ajmsi-1760	336	2	.	.	PUNCT
ajmsi-1760	337	1	lattanzi	lattanzi	PROPN
ajmsi-1760	337	2	,	,	PUNCT
ajmsi-1760	337	3	a.	a.	NOUN
ajmsi-1760	337	4	,	,	PUNCT
ajmsi-1760	337	5	camarena	camarena	PROPN
ajmsi-1760	337	6	,	,	PUNCT
ajmsi-1760	337	7	j.	j.	PROPN
ajmsi-1760	337	8	,	,	PUNCT
ajmsi-1760	337	9	lahiri	lahiri	PROPN
ajmsi-1760	337	10	,	,	PUNCT
ajmsi-1760	337	11	p.	p.	PROPN
ajmsi-1760	337	12	,	,	PUNCT
ajmsi-1760	337	13	segal	segal	PROPN
ajmsi-1760	337	14	,	,	PUNCT
ajmsi-1760	337	15	h.	h.	PROPN
ajmsi-1760	337	16	,	,	PUNCT
ajmsi-1760	337	17	srifa	srifa	PROPN
ajmsi-1760	337	18	,	,	PUNCT
ajmsi-1760	337	19	w.	w.	PROPN
ajmsi-1760	337	20	,	,	PUNCT
ajmsi-1760	337	21	vakulskas	vakulskas	PROPN
ajmsi-1760	337	22	,	,	PUNCT
ajmsi-1760	337	23	c.	c.	PROPN
ajmsi-1760	337	24	a.	a.	PROPN
ajmsi-1760	337	25	&	&	CCONJ
ajmsi-1760	337	26	et	et	PROPN
ajmsi-1760	337	27	al	al	PROPN
ajmsi-1760	337	28	.	.	PROPN
ajmsi-1760	338	1	(	(	PUNCT
ajmsi-1760	338	2	2021	2021	NUM
ajmsi-1760	338	3	)	)	PUNCT
ajmsi-1760	338	4	.	.	PUNCT
ajmsi-1760	339	1	development	development	NOUN
ajmsi-1760	339	2	of	of	ADP
ajmsi-1760	339	3	β	β	ADJ
ajmsi-1760	339	4	-	-	ADJ
ajmsi-1760	339	5	globin	globin	ADJ
ajmsi-1760	339	6	gene	gene	NOUN
ajmsi-1760	339	7	correction	correction	NOUN
ajmsi-1760	339	8	in	in	ADP
ajmsi-1760	339	9	human	human	ADJ
ajmsi-1760	339	10	hematopoietic	hematopoietic	ADJ
ajmsi-1760	339	11	stem	stem	NOUN
ajmsi-1760	339	12	cells	cell	NOUN
ajmsi-1760	339	13	as	as	ADP
ajmsi-1760	339	14	a	a	DET
ajmsi-1760	339	15	potential	potential	ADJ
ajmsi-1760	339	16	durable	durable	ADJ
ajmsi-1760	339	17	treatment	treatment	NOUN
ajmsi-1760	339	18	for	for	ADP
ajmsi-1760	339	19	sickle	sickle	NOUN
ajmsi-1760	339	20	cell	cell	NOUN
ajmsi-1760	339	21	disease	disease	NOUN
ajmsi-1760	339	22	.	.	PUNCT
ajmsi-1760	340	1	science	science	NOUN
ajmsi-1760	340	2	translational	translational	ADJ
ajmsi-1760	340	3	medicine	medicine	NOUN
ajmsi-1760	340	4	,	,	PUNCT
ajmsi-1760	340	5	3(598	3(598	NUM
ajmsi-1760	340	6	)	)	PUNCT
ajmsi-1760	340	7	,	,	PUNCT
ajmsi-1760	340	8	eabf2444	eabf2444	PROPN
ajmsi-1760	340	9	.	.	PUNCT
ajmsi-1760	341	1	https://doi.org/10.1126/scitranslmed.abf2444	https://doi.org/10.1126/scitranslmed.abf2444	PROPN
ajmsi-1760	341	2	.	.	PUNCT
ajmsi-1760	341	3	magis	magis	PROPN
ajmsi-1760	341	4	,	,	PUNCT
ajmsi-1760	341	5	w.	w.	PROPN
ajmsi-1760	341	6	,	,	PUNCT
ajmsi-1760	341	7	dewitt	dewitt	PROPN
ajmsi-1760	341	8	,	,	PUNCT
ajmsi-1760	341	9	m.	m.	NOUN
ajmsi-1760	341	10	a.	a.	PROPN
ajmsi-1760	341	11	,	,	PUNCT
ajmsi-1760	341	12	wyman	wyman	NOUN
ajmsi-1760	341	13	,	,	PUNCT
ajmsi-1760	341	14	s.	s.	PROPN
ajmsi-1760	341	15	k.	k.	PROPN
ajmsi-1760	341	16	,	,	PUNCT
ajmsi-1760	341	17	vu	vu	PROPN
ajmsi-1760	341	18	,	,	PUNCT
ajmsi-1760	341	19	j.	j.	PROPN
ajmsi-1760	341	20	t.	t.	PROPN
ajmsi-1760	341	21	,	,	PUNCT
ajmsi-1760	341	22	heo	heo	PROPN
ajmsi-1760	341	23	,	,	PUNCT
ajmsi-1760	341	24	s.	s.	PROPN
ajmsi-1760	341	25	,	,	PUNCT
ajmsi-1760	341	26	shao	shao	PROPN
ajmsi-1760	341	27	,	,	PUNCT
ajmsi-1760	341	28	s.	s.	PROPN
ajmsi-1760	341	29	j.	j.	PROPN
ajmsi-1760	341	30	&	&	CCONJ
ajmsi-1760	341	31	et	et	PROPN
ajmsi-1760	341	32	al	al	PROPN
ajmsi-1760	341	33	.	.	PROPN
ajmsi-1760	341	34	(	(	PUNCT
ajmsi-1760	341	35	2018	2018	NUM
ajmsi-1760	341	36	)	)	PUNCT
ajmsi-1760	341	37	.	.	PUNCT
ajmsi-1760	342	1	in	in	ADP
ajmsi-1760	342	2	vivo	vivo	ADJ
ajmsi-1760	342	3	selection	selection	NOUN
ajmsi-1760	342	4	for	for	ADP
ajmsi-1760	342	5	corrected	correct	VERB
ajmsi-1760	342	6	ß	ß	PRON
ajmsi-1760	342	7	-	-	ADJ
ajmsi-1760	342	8	globin	globin	ADJ
ajmsi-1760	342	9	alleles	allele	NOUN
ajmsi-1760	342	10	after	after	ADP
ajmsi-1760	342	11	crispr	crispr	NOUN
ajmsi-1760	342	12	/	/	SYM
ajmsi-1760	342	13	cas9	cas9	NOUN
ajmsi-1760	342	14	editing	editing	NOUN
ajmsi-1760	342	15	in	in	ADP
ajmsi-1760	342	16	human	human	ADJ
ajmsi-1760	342	17	sickle	sickle	NOUN
ajmsi-1760	342	18	hematopoietic	hematopoietic	ADJ
ajmsi-1760	342	19	stem	stem	NOUN
ajmsi-1760	342	20	cells	cell	NOUN
ajmsi-1760	342	21	enhances	enhance	VERB
ajmsi-1760	342	22	therapeutic	therapeutic	ADJ
ajmsi-1760	342	23	potential	potential	NOUN
ajmsi-1760	342	24	.	.	PUNCT
ajmsi-1760	343	1	biorxiv	biorxiv	NOUN
ajmsi-1760	343	2	,	,	PUNCT
ajmsi-1760	343	3	https://doi.org/10.1101/432716	https://doi.org/10.1101/432716	NOUN
ajmsi-1760	343	4	.	.	PUNCT
ajmsi-1760	344	1	mandal	mandal	PROPN
ajmsi-1760	344	2	,	,	PUNCT
ajmsi-1760	344	3	p.	p.	PROPN
ajmsi-1760	344	4	k.	k.	PROPN
ajmsi-1760	344	5	,	,	PUNCT
ajmsi-1760	344	6	ferreira	ferreira	PROPN
ajmsi-1760	344	7	,	,	PUNCT
ajmsi-1760	344	8	l.	l.	PROPN
ajmsi-1760	344	9	m.	m.	PROPN
ajmsi-1760	344	10	,	,	PUNCT
ajmsi-1760	344	11	collins	collins	PROPN
ajmsi-1760	344	12	,	,	PUNCT
ajmsi-1760	344	13	r.	r.	PROPN
ajmsi-1760	344	14	,	,	PUNCT
ajmsi-1760	344	15	meissner	meissner	PROPN
ajmsi-1760	344	16	,	,	PUNCT
ajmsi-1760	344	17	t.	t.	PROPN
ajmsi-1760	344	18	b.	b.	PROPN
ajmsi-1760	344	19	,	,	PUNCT
ajmsi-1760	344	20	boutwell	boutwell	PROPN
ajmsi-1760	344	21	,	,	PUNCT
ajmsi-1760	344	22	c.	c.	PROPN
ajmsi-1760	344	23	l.	l.	PROPN
ajmsi-1760	344	24	,	,	PUNCT
ajmsi-1760	344	25	friesen	friesen	PROPN
ajmsi-1760	344	26	,	,	PUNCT
ajmsi-1760	344	27	m.	m.	NOUN
ajmsi-1760	344	28	&	&	CCONJ
ajmsi-1760	344	29	et	et	PROPN
ajmsi-1760	344	30	al	al	PROPN
ajmsi-1760	344	31	.	.	PROPN
ajmsi-1760	345	1	(	(	PUNCT
ajmsi-1760	345	2	2014	2014	NUM
ajmsi-1760	345	3	)	)	PUNCT
ajmsi-1760	345	4	.	.	PUNCT
ajmsi-1760	346	1	efficient	efficient	ADJ
ajmsi-1760	346	2	ablation	ablation	NOUN
ajmsi-1760	346	3	of	of	ADP
ajmsi-1760	346	4	genes	gene	NOUN
ajmsi-1760	346	5	in	in	ADP
ajmsi-1760	346	6	human	human	ADJ
ajmsi-1760	346	7	hematopoietic	hematopoietic	ADJ
ajmsi-1760	346	8	stem	stem	NOUN
ajmsi-1760	346	9	and	and	CCONJ
ajmsi-1760	346	10	effector	effector	NOUN
ajmsi-1760	346	11	cells	cell	NOUN
ajmsi-1760	346	12	using	use	VERB
ajmsi-1760	346	13	crispr	crispr	ADJ
ajmsi-1760	346	14	/	/	SYM
ajmsi-1760	346	15	cas9	cas9	NOUN
ajmsi-1760	346	16	.	.	PUNCT
ajmsi-1760	347	1	stem	stem	NOUN
ajmsi-1760	347	2	cell	cell	NOUN
ajmsi-1760	347	3	,	,	PUNCT
ajmsi-1760	347	4	15(5	15(5	NUM
ajmsi-1760	347	5	)	)	PUNCT
ajmsi-1760	347	6	,	,	PUNCT
ajmsi-1760	347	7	643	643	NUM
ajmsi-1760	347	8	-	-	SYM
ajmsi-1760	347	9	652	652	NUM
ajmsi-1760	347	10	.	.	PUNCT
ajmsi-1760	348	1	https://doi.org/10.1016/j.stem.2014.10.004	https://doi.org/10.1016/j.stem.2014.10.004	NOUN
ajmsi-1760	348	2	.	.	PUNCT
ajmsi-1760	349	1	national	national	ADJ
ajmsi-1760	349	2	heart	heart	NOUN
ajmsi-1760	349	3	,	,	PUNCT
ajmsi-1760	349	4	lung	lung	NOUN
ajmsi-1760	349	5	,	,	PUNCT
ajmsi-1760	349	6	and	and	CCONJ
ajmsi-1760	349	7	blood	blood	NOUN
ajmsi-1760	349	8	institute	institute	NOUN
ajmsi-1760	349	9	.	.	PUNCT
ajmsi-1760	350	1	(	(	PUNCT
ajmsi-1760	350	2	2015	2015	NUM
ajmsi-1760	350	3	)	)	PUNCT
ajmsi-1760	350	4	.	.	PUNCT
ajmsi-1760	351	1	“	"	PUNCT
ajmsi-1760	351	2	what	what	PRON
ajmsi-1760	351	3	is	be	AUX
ajmsi-1760	351	4	sickle	sickle	NOUN
ajmsi-1760	351	5	cell	cell	NOUN
ajmsi-1760	351	6	disease	disease	NOUN
ajmsi-1760	351	7	?	?	PUNCT
ajmsi-1760	351	8	”	"	PUNCT
ajmsi-1760	351	9	,	,	PUNCT
ajmsi-1760	351	10	available	available	ADJ
ajmsi-1760	351	11	online	online	ADV
ajmsi-1760	351	12	:	:	PUNCT
ajmsi-1760	351	13	https://www.nhlbi	https://www.nhlbi	PROPN
ajmsi-1760	351	14	.	.	PUNCT
ajmsi-1760	352	1	nihgov	nihgov	ADJ
ajmsi-1760	352	2	/	/	SYM
ajmsi-1760	352	3	health	health	NOUN
ajmsi-1760	352	4	/	/	SYM
ajmsi-1760	352	5	sickle	sickle	NOUN
ajmsi-1760	352	6	-	-	PUNCT
ajmsi-1760	352	7	cell	cell	NOUN
ajmsi-1760	352	8	-	-	PUNCT
ajmsi-1760	352	9	disease	disease	NOUN
ajmsi-1760	352	10	onda	onda	NOUN
ajmsi-1760	352	11	,	,	PUNCT
ajmsi-1760	352	12	m.	m.	NOUN
ajmsi-1760	352	13	,	,	PUNCT
ajmsi-1760	352	14	akaishi	akaishi	PROPN
ajmsi-1760	352	15	,	,	PUNCT
ajmsi-1760	352	16	j.	j.	PROPN
ajmsi-1760	352	17	,	,	PUNCT
ajmsi-1760	352	18	asaka	asaka	PROPN
ajmsi-1760	352	19	,	,	PUNCT
ajmsi-1760	352	20	s.	s.	PROPN
ajmsi-1760	352	21	,	,	PUNCT
ajmsi-1760	352	22	okamoto	okamoto	PROPN
ajmsi-1760	352	23	,	,	PUNCT
ajmsi-1760	352	24	j.	j.	PROPN
ajmsi-1760	352	25	,	,	PUNCT
ajmsi-1760	352	26	miyamoto	miyamoto	PROPN
ajmsi-1760	352	27	,	,	PUNCT
ajmsi-1760	352	28	s.	s.	PROPN
ajmsi-1760	352	29	,	,	PUNCT
ajmsi-1760	352	30	mizutani	mizutani	PROPN
ajmsi-1760	352	31	,	,	PUNCT
ajmsi-1760	352	32	k.	k.	PROPN
ajmsi-1760	352	33	&	&	CCONJ
ajmsi-1760	352	34	et	et	PROPN
ajmsi-1760	352	35	al	al	PROPN
ajmsi-1760	352	36	.	.	PROPN
ajmsi-1760	352	37	(	(	PUNCT
ajmsi-1760	352	38	2005	2005	NUM
ajmsi-1760	352	39	)	)	PUNCT
ajmsi-1760	352	40	.	.	PUNCT
ajmsi-1760	353	1	decrease	decrease	NOUN
ajmsi-1760	353	2	expression	expression	NOUN
ajmsi-1760	353	3	of	of	ADP
ajmsi-1760	353	4	haemoglobin	haemoglobin	PROPN
ajmsi-1760	353	5	beta	beta	PROPN
ajmsi-1760	353	6	(	(	PUNCT
ajmsi-1760	353	7	hbb	hbb	PROPN
ajmsi-1760	353	8	)	)	PUNCT
ajmsi-1760	353	9	gene	gene	NOUN
ajmsi-1760	353	10	in	in	ADP
ajmsi-1760	353	11	anaplastic	anaplastic	ADJ
ajmsi-1760	353	12	thyroid	thyroid	NOUN
ajmsi-1760	353	13	cancer	cancer	NOUN
ajmsi-1760	353	14	and	and	CCONJ
ajmsi-1760	353	15	recovery	recovery	NOUN
ajmsi-1760	353	16	of	of	ADP
ajmsi-1760	353	17	its	its	PRON
ajmsi-1760	353	18	expression	expression	NOUN
ajmsi-1760	353	19	inhibits	inhibit	VERB
ajmsi-1760	353	20	cell	cell	NOUN
ajmsi-1760	353	21	growth	growth	NOUN
ajmsi-1760	353	22	.	.	PUNCT
ajmsi-1760	354	1	british	british	ADJ
ajmsi-1760	354	2	journal	journal	PROPN
ajmsi-1760	354	3	of	of	ADP
ajmsi-1760	354	4	cancer	cancer	NOUN
ajmsi-1760	354	5	,	,	PUNCT
ajmsi-1760	354	6	92	92	NUM
ajmsi-1760	354	7	,	,	PUNCT
ajmsi-1760	354	8	2216	2216	NUM
ajmsi-1760	354	9	-	-	SYM
ajmsi-1760	354	10	2224	2224	NUM
ajmsi-1760	354	11	.	.	PUNCT
ajmsi-1760	355	1	https://	https://	PROPN
ajmsi-1760	355	2	doi.org/10.1038/sj/bjc.6602634	doi.org/10.1038/sj/bjc.6602634	PROPN
ajmsi-1760	355	3	.	.	PUNCT
ajmsi-1760	356	1	orkin	orkin	PROPN
ajmsi-1760	356	2	,	,	PUNCT
ajmsi-1760	356	3	s.	s.	PROPN
ajmsi-1760	356	4	h.	h.	PROPN
ajmsi-1760	356	5	&	&	CCONJ
ajmsi-1760	356	6	bauer	bauer	PROPN
ajmsi-1760	356	7	,	,	PUNCT
ajmsi-1760	356	8	d.	d.	PROPN
ajmsi-1760	356	9	e.	e.	PROPN
ajmsi-1760	356	10	(	(	PUNCT
ajmsi-1760	356	11	2019	2019	NUM
ajmsi-1760	356	12	)	)	PUNCT
ajmsi-1760	356	13	.	.	PUNCT
ajmsi-1760	357	1	emerging	emerge	VERB
ajmsi-1760	357	2	genetic	genetic	ADJ
ajmsi-1760	357	3	therapy	therapy	NOUN
ajmsi-1760	357	4	for	for	ADP
ajmsi-1760	357	5	sickle	sickle	NOUN
ajmsi-1760	357	6	cell	cell	NOUN
ajmsi-1760	357	7	disease	disease	NOUN
ajmsi-1760	357	8	.	.	PUNCT
ajmsi-1760	358	1	annual	annual	ADJ
ajmsi-1760	358	2	review	review	NOUN
ajmsi-1760	358	3	of	of	ADP
ajmsi-1760	358	4	medicine	medicine	NOUN
ajmsi-1760	358	5	,	,	PUNCT
ajmsi-1760	358	6	70(1	70(1	NOUN
ajmsi-1760	358	7	)	)	PUNCT
ajmsi-1760	358	8	,	,	PUNCT
ajmsi-1760	358	9	257–271	257–271	NUM
ajmsi-1760	358	10	.	.	PUNCT
ajmsi-1760	359	1	pandey	pandey	PROPN
ajmsi-1760	359	2	,	,	PUNCT
ajmsi-1760	359	3	v.	v.	PROPN
ajmsi-1760	359	4	k.	k.	PROPN
ajmsi-1760	359	5	,	,	PUNCT
ajmsi-1760	359	6	tripathi	tripathi	PROPN
ajmsi-1760	359	7	,	,	PUNCT
ajmsi-1760	359	8	a.	a.	PROPN
ajmsi-1760	359	9	,	,	PUNCT
ajmsi-1760	359	10	bhushan	bhushan	PROPN
ajmsi-1760	359	11	,	,	PUNCT
ajmsi-1760	359	12	r.	r.	PROPN
ajmsi-1760	359	13	,	,	PUNCT
ajmsi-1760	359	14	ali	ali	PROPN
ajmsi-1760	359	15	,	,	PUNCT
ajmsi-1760	359	16	a.	a.	PROPN
ajmsi-1760	359	17	&	&	CCONJ
ajmsi-1760	359	18	dubey	dubey	PROPN
ajmsi-1760	359	19	,	,	PUNCT
ajmsi-1760	359	20	p.	p.	PROPN
ajmsi-1760	359	21	k.	k.	PROPN
ajmsi-1760	359	22	(	(	PUNCT
ajmsi-1760	359	23	2017	2017	NUM
ajmsi-1760	359	24	)	)	PUNCT
ajmsi-1760	359	25	.	.	PUNCT
ajmsi-1760	360	1	application	application	NOUN
ajmsi-1760	360	2	of	of	ADP
ajmsi-1760	360	3	crispr	crispr	ADJ
ajmsi-1760	360	4	/	/	SYM
ajmsi-1760	360	5	cas9	cas9	NOUN
ajmsi-1760	360	6	genome	genome	NOUN
ajmsi-1760	360	7	editing	editing	NOUN
ajmsi-1760	360	8	in	in	ADP
ajmsi-1760	360	9	genetic	genetic	ADJ
ajmsi-1760	360	10	disorders	disorder	NOUN
ajmsi-1760	360	11	:	:	PUNCT
ajmsi-1760	360	12	a	a	DET
ajmsi-1760	360	13	systematic	systematic	ADJ
ajmsi-1760	360	14	review	review	NOUN
ajmsi-1760	360	15	up	up	ADP
ajmsi-1760	360	16	to	to	ADP
ajmsi-1760	360	17	date	date	NOUN
ajmsi-1760	360	18	.	.	PUNCT
ajmsi-1760	361	1	journal	journal	NOUN
ajmsi-1760	361	2	of	of	ADP
ajmsi-1760	361	3	genetic	genetic	ADJ
ajmsi-1760	361	4	syndromes	syndrome	NOUN
ajmsi-1760	361	5	&	&	CCONJ
ajmsi-1760	361	6	gene	gene	NOUN
ajmsi-1760	361	7	therapy	therapy	NOUN
ajmsi-1760	361	8	,	,	PUNCT
ajmsi-1760	361	9	8(2	8(2	NUM
ajmsi-1760	361	10	)	)	PUNCT
ajmsi-1760	361	11	,	,	PUNCT
ajmsi-1760	361	12	321	321	NUM
ajmsi-1760	361	13	-	-	SYM
ajmsi-1760	361	14	331	331	NUM
ajmsi-1760	361	15	.	.	PUNCT
ajmsi-1760	362	1	https://doi.org/10.4172/21577412.1000321	https://doi.org/10.4172/21577412.1000321	NOUN
ajmsi-1760	362	2	.	.	PUNCT
ajmsi-1760	363	1	park	park	PROPN
ajmsi-1760	363	2	,	,	PUNCT
ajmsi-1760	363	3	s.	s.	PROPN
ajmsi-1760	363	4	h.	h.	PROPN
ajmsi-1760	363	5	,	,	PUNCT
ajmsi-1760	363	6	lee	lee	PROPN
ajmsi-1760	363	7	,	,	PUNCT
ajmsi-1760	363	8	c.	c.	PROPN
ajmsi-1760	363	9	m.	m.	PROPN
ajmsi-1760	363	10	,	,	PUNCT
ajmsi-1760	363	11	deshmukh	deshmukh	PROPN
ajmsi-1760	363	12	,	,	PUNCT
ajmsi-1760	363	13	h.	h.	PROPN
ajmsi-1760	363	14	&	&	CCONJ
ajmsi-1760	363	15	bao	bao	PROPN
ajmsi-1760	363	16	,	,	PUNCT
ajmsi-1760	363	17	g.	g.	PROPN
ajmsi-1760	363	18	(	(	PUNCT
ajmsi-1760	363	19	2016	2016	NUM
ajmsi-1760	363	20	)	)	PUNCT
ajmsi-1760	363	21	.	.	PUNCT
ajmsi-1760	364	1	therapeutic	therapeutic	ADJ
ajmsi-1760	364	2	crispr	crispr	ADJ
ajmsi-1760	364	3	/	/	SYM
ajmsi-1760	364	4	cas9	cas9	NOUN
ajmsi-1760	364	5	genome	genome	NOUN
ajmsi-1760	364	6	editing	editing	NOUN
ajmsi-1760	364	7	for	for	ADP
ajmsi-1760	364	8	treating	treat	VERB
ajmsi-1760	364	9	sickle	sickle	NOUN
ajmsi-1760	364	10	cell	cell	NOUN
ajmsi-1760	364	11	disease	disease	NOUN
ajmsi-1760	364	12	.	.	PUNCT
ajmsi-1760	365	1	blood	blood	NOUN
ajmsi-1760	365	2	,	,	PUNCT
ajmsi-1760	365	3	128(22	128(22	NUM
ajmsi-1760	365	4	)	)	PUNCT
ajmsi-1760	365	5	,	,	PUNCT
ajmsi-1760	365	6	4703–4703	4703–4703	NOUN
ajmsi-1760	365	7	.	.	PUNCT
ajmsi-1760	366	1	park	park	PROPN
ajmsi-1760	366	2	,	,	PUNCT
ajmsi-1760	366	3	s.	s.	PROPN
ajmsi-1760	366	4	h.	h.	PROPN
ajmsi-1760	366	5	,	,	PUNCT
ajmsi-1760	366	6	lee	lee	PROPN
ajmsi-1760	366	7	,	,	PUNCT
ajmsi-1760	366	8	c.	c.	PROPN
ajmsi-1760	366	9	m.	m.	PROPN
ajmsi-1760	366	10	,	,	PUNCT
ajmsi-1760	366	11	dever	dever	PROPN
ajmsi-1760	366	12	,	,	PUNCT
ajmsi-1760	366	13	d.	d.	PROPN
ajmsi-1760	366	14	p.	p.	PROPN
ajmsi-1760	366	15	,	,	PUNCT
ajmsi-1760	366	16	davis	davis	PROPN
ajmsi-1760	366	17	,	,	PUNCT
ajmsi-1760	366	18	t.	t.	PROPN
ajmsi-1760	366	19	h.	h.	PROPN
ajmsi-1760	366	20	,	,	PUNCT
ajmsi-1760	366	21	camarena	camarena	PROPN
ajmsi-1760	366	22	,	,	PUNCT
ajmsi-1760	366	23	j.	j.	PROPN
ajmsi-1760	366	24	,	,	PUNCT
ajmsi-1760	366	25	srifa	srifa	PROPN
ajmsi-1760	366	26	,	,	PUNCT
ajmsi-1760	366	27	w.	w.	PROPN
ajmsi-1760	366	28	&	&	CCONJ
ajmsi-1760	366	29	et	et	PROPN
ajmsi-1760	366	30	al	al	PROPN
ajmsi-1760	366	31	.	.	PROPN
ajmsi-1760	367	1	(	(	PUNCT
ajmsi-1760	367	2	2019	2019	NUM
ajmsi-1760	367	3	)	)	PUNCT
ajmsi-1760	367	4	.	.	PUNCT
ajmsi-1760	368	1	highly	highly	ADV
ajmsi-1760	368	2	efficient	efficient	ADJ
ajmsi-1760	368	3	editing	editing	NOUN
ajmsi-1760	368	4	of	of	ADP
ajmsi-1760	368	5	the	the	DET
ajmsi-1760	368	6	β	β	NOUN
ajmsi-1760	368	7	-	-	ADJ
ajmsi-1760	368	8	globin	globin	ADJ
ajmsi-1760	368	9	gene	gene	NOUN
ajmsi-1760	368	10	in	in	ADP
ajmsi-1760	368	11	patient	patient	NOUN
ajmsi-1760	368	12	-	-	PUNCT
ajmsi-1760	368	13	derived	derive	VERB
ajmsi-1760	368	14	hematopoietic	hematopoietic	ADJ
ajmsi-1760	368	15	stem	stem	NOUN
ajmsi-1760	368	16	and	and	CCONJ
ajmsi-1760	368	17	progenitor	progenitor	NOUN
ajmsi-1760	368	18	cells	cell	NOUN
ajmsi-1760	368	19	to	to	PART
ajmsi-1760	368	20	treat	treat	VERB
ajmsi-1760	368	21	sickle	sickle	NOUN
ajmsi-1760	368	22	cell	cell	NOUN
ajmsi-1760	368	23	disease	disease	NOUN
ajmsi-1760	368	24	.	.	PUNCT
ajmsi-1760	369	1	nucleic	nucleic	ADJ
ajmsi-1760	369	2	acids	acid	NOUN
ajmsi-1760	369	3	research	research	NOUN
ajmsi-1760	369	4	,	,	PUNCT
ajmsi-1760	369	5	47(15	47(15	PROPN
ajmsi-1760	369	6	)	)	PUNCT
ajmsi-1760	369	7	,	,	PUNCT
ajmsi-1760	369	8	7955	7955	NUM
ajmsi-1760	369	9	-	-	SYM
ajmsi-1760	369	10	7972	7972	NUM
ajmsi-1760	369	11	.	.	PUNCT
ajmsi-1760	370	1	https://doi	https://doi	X
ajmsi-1760	370	2	.	.	PUNCT
ajmsi-1760	371	1	org/10.1093	org/10.1093	ADJ
ajmsi-1760	371	2	/	/	SYM
ajmsi-1760	371	3	nar	nar	NOUN
ajmsi-1760	371	4	/	/	SYM
ajmsi-1760	371	5	gkz475	gkz475	PROPN
ajmsi-1760	371	6	.	.	PUNCT
ajmsi-1760	372	1	park	park	PROPN
ajmsi-1760	372	2	,	,	PUNCT
ajmsi-1760	372	3	s.	s.	PROPN
ajmsi-1760	372	4	h.	h.	PROPN
ajmsi-1760	372	5	&	&	CCONJ
ajmsi-1760	372	6	bao	bao	PROPN
ajmsi-1760	372	7	,	,	PUNCT
ajmsi-1760	372	8	g.	g.	PROPN
ajmsi-1760	372	9	(	(	PUNCT
ajmsi-1760	372	10	2021)a	2021)a	NUM
ajmsi-1760	372	11	.	.	X
ajmsi-1760	372	12	crispr	crispr	PROPN
ajmsi-1760	372	13	/	/	SYM
ajmsi-1760	372	14	cas9	cas9	NOUN
ajmsi-1760	372	15	gene	gene	NOUN
ajmsi-1760	372	16	editing	edit	VERB
ajmsi-1760	372	17	for	for	ADP
ajmsi-1760	372	18	curing	cure	VERB
ajmsi-1760	372	19	sickle	sickle	NOUN
ajmsi-1760	372	20	cell	cell	NOUN
ajmsi-1760	372	21	disease	disease	NOUN
ajmsi-1760	372	22	.	.	PUNCT
ajmsi-1760	373	1	transfusion	transfusion	NOUN
ajmsi-1760	373	2	and	and	CCONJ
ajmsi-1760	373	3	apheresis	apheresis	NOUN
ajmsi-1760	373	4	science	science	NOUN
ajmsi-1760	373	5	,	,	PUNCT
ajmsi-1760	373	6	60(1	60(1	NUM
ajmsi-1760	373	7	)	)	PUNCT
ajmsi-1760	373	8	,	,	PUNCT
ajmsi-1760	373	9	103060	103060	NUM
ajmsi-1760	373	10	.	.	PUNCT
ajmsi-1760	374	1	https://doi.org/10.1016/j	https://doi.org/10.1016/j	NOUN
ajmsi-1760	374	2	.	.	PUNCT
ajmsi-1760	375	1	transci.2021.103060	transci.2021.103060	ADJ
ajmsi-1760	375	2	.	.	PUNCT
ajmsi-1760	376	1	park	park	NOUN
ajmsi-1760	376	2	,	,	PUNCT
ajmsi-1760	376	3	s.	s.	PROPN
ajmsi-1760	376	4	h.	h.	PROPN
ajmsi-1760	376	5	j.	j.	PROPN
ajmsi-1760	376	6	p.	p.	PROPN
ajmsi-1760	376	7	,	,	PUNCT
ajmsi-1760	376	8	cao	cao	PROPN
ajmsi-1760	376	9	,	,	PUNCT
ajmsi-1760	376	10	m.	m.	NOUN
ajmsi-1760	376	11	,	,	PUNCT
ajmsi-1760	376	12	zhang	zhang	PROPN
ajmsi-1760	376	13	,	,	PUNCT
ajmsi-1760	376	14	y.	y.	PROPN
ajmsi-1760	376	15	,	,	PUNCT
ajmsi-1760	376	16	sheehan	sheehan	PROPN
ajmsi-1760	376	17	,	,	PUNCT
ajmsi-1760	376	18	v.	v.	ADP
ajmsi-1760	377	1	a.	a.	PROPN
ajmsi-1760	377	2	&	&	CCONJ
ajmsi-1760	377	3	bao	bao	PROPN
ajmsi-1760	377	4	,	,	PUNCT
ajmsi-1760	377	5	g.	g.	PROPN
ajmsi-1760	377	6	(	(	PUNCT
ajmsi-1760	377	7	2021)b	2021)b	NUM
ajmsi-1760	377	8	.	.	NOUN
ajmsi-1760	377	9	crispr	crispr	PROPN
ajmsi-1760	377	10	/	/	SYM
ajmsi-1760	377	11	cas9	cas9	NOUN
ajmsi-1760	377	12	editing	editing	NOUN
ajmsi-1760	377	13	induces	induce	VERB
ajmsi-1760	377	14	high	high	ADJ
ajmsi-1760	377	15	rates	rate	NOUN
ajmsi-1760	377	16	of	of	ADP
ajmsi-1760	377	17	unintended	unintended	ADJ
ajmsi-1760	377	18	large	large	ADJ
ajmsi-1760	377	19	gene	gene	NOUN
ajmsi-1760	377	20	modifications	modification	NOUN
ajmsi-1760	377	21	in	in	ADP
ajmsi-1760	377	22	hspcs	hspc	NOUN
ajmsi-1760	377	23	from	from	ADP
ajmsi-1760	377	24	patients	patient	NOUN
ajmsi-1760	377	25	with	with	ADP
ajmsi-1760	377	26	sickle	sickle	NOUN
ajmsi-1760	377	27	cell	cell	NOUN
ajmsi-1760	377	28	disease	disease	NOUN
ajmsi-1760	377	29	.	.	PUNCT
ajmsi-1760	378	1	blood	blood	NOUN
ajmsi-1760	378	2	,	,	PUNCT
ajmsi-1760	378	3	138(suppl.1	138(suppl.1	NUM
ajmsi-1760	378	4	)	)	PUNCT
ajmsi-1760	378	5	,	,	PUNCT
ajmsi-1760	378	6	3969–3969	3969–3969	NUM
ajmsi-1760	378	7	.	.	PUNCT
ajmsi-1760	379	1	piel	piel	PROPN
ajmsi-1760	379	2	,	,	PUNCT
ajmsi-1760	379	3	f.	f.	PROPN
ajmsi-1760	379	4	b.	b.	PROPN
ajmsi-1760	379	5	(	(	PUNCT
ajmsi-1760	379	6	2013	2013	NUM
ajmsi-1760	379	7	)	)	PUNCT
ajmsi-1760	379	8	.	.	PUNCT
ajmsi-1760	380	1	global	global	ADJ
ajmsi-1760	380	2	burden	burden	NOUN
ajmsi-1760	380	3	of	of	ADP
ajmsi-1760	380	4	sickle	sickle	NOUN
ajmsi-1760	380	5	cell	cell	NOUN
ajmsi-1760	380	6	anaemia	anaemia	NOUN
ajmsi-1760	380	7	in	in	ADP
ajmsi-1760	380	8	children	child	NOUN
ajmsi-1760	380	9	under	under	ADP
ajmsi-1760	380	10	five	five	NUM
ajmsi-1760	380	11	,	,	PUNCT
ajmsi-1760	380	12	2010	2010	NUM
ajmsi-1760	380	13	-	-	SYM
ajmsi-1760	380	14	2050	2050	NUM
ajmsi-1760	380	15	:	:	PUNCT
ajmsi-1760	380	16	modelling	modelling	NOUN
ajmsi-1760	380	17	based	base	VERB
ajmsi-1760	380	18	on	on	ADP
ajmsi-1760	380	19	demographics	demographic	NOUN
ajmsi-1760	380	20	,	,	PUNCT
ajmsi-1760	380	21	excess	excess	ADJ
ajmsi-1760	380	22	mortality	mortality	NOUN
ajmsi-1760	380	23	,	,	PUNCT
ajmsi-1760	380	24	and	and	CCONJ
ajmsi-1760	380	25	interventions	intervention	NOUN
ajmsi-1760	380	26	.	.	PUNCT
ajmsi-1760	381	1	plos	plos	PROPN
ajmsi-1760	381	2	medicine	medicine	PROPN
ajmsi-1760	381	3	,	,	PUNCT
ajmsi-1760	381	4	10(7	10(7	NUM
ajmsi-1760	381	5	)	)	PUNCT
ajmsi-1760	381	6	,	,	PUNCT
ajmsi-1760	381	7	e1001484	e1001484	NOUN
ajmsi-1760	381	8	.	.	PUNCT
ajmsi-1760	382	1	https://doi.org/10.1371/	https://doi.org/10.1371/	PROPN
ajmsi-1760	382	2	journal.pmed.1001484	journal.pmed.1001484	PROPN
ajmsi-1760	382	3	.	.	PUNCT
ajmsi-1760	383	1	pinhas	pinhas	PROPN
ajmsi-1760	383	2	,	,	PUNCT
ajmsi-1760	383	3	a.	a.	PROPN
ajmsi-1760	383	4	,	,	PUNCT
ajmsi-1760	383	5	zhou	zhou	PROPN
ajmsi-1760	383	6	,	,	PUNCT
ajmsi-1760	383	7	d.	d.	PROPN
ajmsi-1760	383	8	b.	b.	PROPN
ajmsi-1760	383	9	,	,	PUNCT
ajmsi-1760	383	10	otero	otero	PROPN
ajmsi-1760	383	11	-	-	PUNCT
ajmsi-1760	383	12	marquez	marquez	PROPN
ajmsi-1760	383	13	,	,	PUNCT
ajmsi-1760	383	14	o.	o.	ADJ
ajmsi-1760	383	15	,	,	PUNCT
ajmsi-1760	383	16	castanostoral	castanostoral	ADJ
ajmsi-1760	383	17	,	,	PUNCT
ajmsi-1760	383	18	m.	m.	NOUN
ajmsi-1760	383	19	v.	v.	NOUN
ajmsi-1760	383	20	,	,	PUNCT
ajmsi-1760	383	21	migacz	migacz	NOUN
ajmsi-1760	383	22	,	,	PUNCT
ajmsi-1760	383	23	j.	j.	PROPN
ajmsi-1760	383	24	v.	v.	PROPN
ajmsi-1760	383	25	,	,	PUNCT
ajmsi-1760	383	26	glassberg	glassberg	PROPN
ajmsi-1760	383	27	,	,	PUNCT
ajmsi-1760	383	28	j.	j.	PROPN
ajmsi-1760	383	29	&	&	CCONJ
ajmsi-1760	383	30	et	et	PROPN
ajmsi-1760	383	31	al	al	PROPN
ajmsi-1760	383	32	.	.	PROPN
ajmsi-1760	383	33	(	(	PUNCT
ajmsi-1760	383	34	2022	2022	NUM
ajmsi-1760	383	35	)	)	PUNCT
ajmsi-1760	383	36	.	.	PUNCT
ajmsi-1760	384	1	efficacy	efficacy	NOUN
ajmsi-1760	384	2	of	of	ADP
ajmsi-1760	384	3	crispr	crispr	NOUN
ajmsi-1760	384	4	-	-	PUNCT
ajmsi-1760	384	5	based	base	VERB
ajmsi-1760	384	6	gene	gene	NOUN
ajmsi-1760	384	7	editing	edit	VERB
ajmsi-1760	384	8	in	in	ADP
ajmsi-1760	384	9	a	a	DET
ajmsi-1760	384	10	sickle	sickle	NOUN
ajmsi-1760	384	11	cell	cell	NOUN
ajmsi-1760	384	12	disease	disease	NOUN
ajmsi-1760	384	13	patient	patient	ADJ
ajmsi-1760	384	14	as	as	SCONJ
ajmsi-1760	384	15	measured	measure	VERB
ajmsi-1760	384	16	through	through	ADP
ajmsi-1760	384	17	the	the	DET
ajmsi-1760	384	18	eye	eye	NOUN
ajmsi-1760	384	19	.	.	PUNCT
ajmsi-1760	385	1	case	case	NOUN
ajmsi-1760	385	2	reports	report	VERB
ajmsi-1760	385	3	in	in	ADP
ajmsi-1760	385	4	hematology	hematology	NOUN
ajmsi-1760	385	5	,	,	PUNCT
ajmsi-1760	385	6	2022	2022	NUM
ajmsi-1760	385	7	,	,	PUNCT
ajmsi-1760	385	8	6079631	6079631	NUM
ajmsi-1760	385	9	.	.	PUNCT
ajmsi-1760	386	1	https://doi	https://doi	X
ajmsi-1760	386	2	.	.	PUNCT
ajmsi-1760	387	1	org/10.1155/2022/6079631	org/10.1155/2022/6079631	NUM
ajmsi-1760	387	2	.	.	PUNCT
ajmsi-1760	388	1	ramadier	ramadier	NOUN
ajmsi-1760	388	2	,	,	PUNCT
ajmsi-1760	388	3	s.	s.	PROPN
ajmsi-1760	388	4	,	,	PUNCT
ajmsi-1760	388	5	chalumeau	chalumeau	PROPN
ajmsi-1760	388	6	,	,	PUNCT
ajmsi-1760	388	7	a.	a.	PROPN
ajmsi-1760	388	8	,	,	PUNCT
ajmsi-1760	388	9	felix	felix	PROPN
ajmsi-1760	388	10	,	,	PUNCT
ajmsi-1760	388	11	t.	t.	PROPN
ajmsi-1760	388	12	,	,	PUNCT
ajmsi-1760	388	13	othman	othman	PROPN
ajmsi-1760	388	14	,	,	PUNCT
ajmsi-1760	388	15	n.	n.	NOUN
ajmsi-1760	388	16	,	,	PUNCT
ajmsi-1760	388	17	aknoun	aknoun	PROPN
ajmsi-1760	388	18	,	,	PUNCT
ajmsi-1760	388	19	s.	s.	PROPN
ajmsi-1760	388	20	,	,	PUNCT
ajmsi-1760	388	21	casini	casini	PROPN
ajmsi-1760	388	22	,	,	PUNCT
ajmsi-1760	388	23	a.	a.	PROPN
ajmsi-1760	388	24	&	&	CCONJ
ajmsi-1760	388	25	et	et	PROPN
ajmsi-1760	388	26	al	al	PROPN
ajmsi-1760	388	27	.	.	PROPN
ajmsi-1760	389	1	(	(	PUNCT
ajmsi-1760	389	2	2022	2022	NUM
ajmsi-1760	389	3	)	)	PUNCT
ajmsi-1760	389	4	.	.	PUNCT
ajmsi-1760	390	1	combination	combination	NOUN
ajmsi-1760	390	2	of	of	ADP
ajmsi-1760	390	3	lentiviral	lentiviral	ADJ
ajmsi-1760	390	4	and	and	CCONJ
ajmsi-1760	390	5	genome	genome	NOUN
ajmsi-1760	390	6	editing	editing	NOUN
ajmsi-1760	390	7	technologies	technology	NOUN
ajmsi-1760	390	8	for	for	ADP
ajmsi-1760	390	9	the	the	DET
ajmsi-1760	390	10	treatment	treatment	NOUN
ajmsi-1760	390	11	of	of	ADP
ajmsi-1760	390	12	sickle	sickle	NOUN
ajmsi-1760	390	13	cell	cell	NOUN
ajmsi-1760	390	14	disease	disease	NOUN
ajmsi-1760	390	15	.	.	PUNCT
ajmsi-1760	391	1	molecular	molecular	ADJ
ajmsi-1760	391	2	therapy	therapy	NOUN
ajmsi-1760	391	3	,	,	PUNCT
ajmsi-1760	391	4	30(1	30(1	NUM
ajmsi-1760	391	5	)	)	PUNCT
ajmsi-1760	391	6	,	,	PUNCT
ajmsi-1760	391	7	145–163	145–163	NUM
ajmsi-1760	391	8	.	.	PUNCT
ajmsi-1760	391	9	https://doi.org/10.1016/j.ymthe.2021.08.019	https://doi.org/10.1016/j.ymthe.2021.08.019	X
ajmsi-1760	391	10	.	.	PUNCT
ajmsi-1760	392	1	ranadive	ranadive	PROPN
ajmsi-1760	392	2	,	,	PUNCT
ajmsi-1760	392	3	a.	a.	NOUN
ajmsi-1760	392	4	&	&	CCONJ
ajmsi-1760	392	5	linga	linga	PROPN
ajmsi-1760	392	6	-	-	PUNCT
ajmsi-1760	392	7	easwaran	easwaran	ADV
ajmsi-1760	392	8	,	,	PUNCT
ajmsi-1760	392	9	j.	j.	PROPN
ajmsi-1760	392	10	(	(	PUNCT
ajmsi-1760	392	11	2022	2022	NUM
ajmsi-1760	392	12	)	)	PUNCT
ajmsi-1760	392	13	.	.	PUNCT
ajmsi-1760	393	1	current	current	ADJ
ajmsi-1760	393	2	sickle	sickle	NOUN
ajmsi-1760	393	3	cell	cell	NOUN
ajmsi-1760	393	4	disease	disease	NOUN
ajmsi-1760	393	5	gene	gene	NOUN
ajmsi-1760	393	6	therapy	therapy	NOUN
ajmsi-1760	393	7	treatments	treatment	NOUN
ajmsi-1760	393	8	:	:	PUNCT
ajmsi-1760	393	9	literature	literature	PROPN
ajmsi-1760	393	10	review	review	PROPN
ajmsi-1760	393	11	.	.	PUNCT
ajmsi-1760	394	1	journal	journal	PROPN
ajmsi-1760	394	2	of	of	ADP
ajmsi-1760	394	3	student	student	NOUN
ajmsi-1760	394	4	research	research	NOUN
ajmsi-1760	394	5	,	,	PUNCT
ajmsi-1760	394	6	1(1	1(1	NUM
ajmsi-1760	394	7	)	)	PUNCT
ajmsi-1760	394	8	.	.	PUNCT
ajmsi-1760	395	1	https://doi	https://doi	X
ajmsi-1760	395	2	.	.	PUNCT
ajmsi-1760	395	3	org/10.47611	org/10.47611	VERB
ajmsi-1760	395	4	/	/	SYM
ajmsi-1760	395	5	jsr.v11i1.1534	jsr.v11i1.1534	PROPN
ajmsi-1760	395	6	.	.	PUNCT
ajmsi-1760	395	7	rodriguez	rodriguez	PROPN
ajmsi-1760	395	8	rodriguez	rodriguez	PROPN
ajmsi-1760	395	9	,	,	PUNCT
ajmsi-1760	395	10	d.	d.	PROPN
ajmsi-1760	395	11	,	,	PUNCT
ajmsi-1760	395	12	ramirez	ramirez	PROPN
ajmsi-1760	395	13	solis	solis	PROPN
ajmsi-1760	395	14	,	,	PUNCT
ajmsi-1760	395	15	r.	r.	PROPN
ajmsi-1760	395	16	,	,	PUNCT
ajmsi-1760	395	17	garza	garza	PROPN
ajmsi-1760	395	18	elizondo	elizondo	PROPN
ajmsi-1760	395	19	,	,	PUNCT
ajmsi-1760	395	20	m.	m.	NOUN
ajmsi-1760	395	21	,	,	PUNCT
ajmsi-1760	395	22	garza	garza	PROPN
ajmsi-1760	395	23	rodriguez	rodriguez	PROPN
ajmsi-1760	395	24	,	,	PUNCT
ajmsi-1760	395	25	m.	m.	NOUN
ajmsi-1760	395	26	&	&	CCONJ
ajmsi-1760	395	27	barrera	barrera	PROPN
ajmsi-1760	395	28	saldaia	saldaia	PROPN
ajmsi-1760	395	29	,	,	PUNCT
ajmsi-1760	395	30	h.	h.	PROPN
ajmsi-1760	395	31	(	(	PUNCT
ajmsi-1760	395	32	2019	2019	NUM
ajmsi-1760	395	33	)	)	PUNCT
ajmsi-1760	395	34	.	.	PUNCT
ajmsi-1760	396	1	genome	genome	NOUN
ajmsi-1760	396	2	editing	editing	NOUN
ajmsi-1760	396	3	:	:	PUNCT
ajmsi-1760	396	4	a	a	DET
ajmsi-1760	396	5	perspective	perspective	NOUN
ajmsi-1760	396	6	on	on	ADP
ajmsi-1760	396	7	the	the	DET
ajmsi-1760	396	8	application	application	NOUN
ajmsi-1760	396	9	of	of	ADP
ajmsi-1760	396	10	crispr	crispr	NOUN
ajmsi-1760	396	11	/	/	SYM
ajmsi-1760	396	12	cas9	cas9	NOUN
ajmsi-1760	396	13	to	to	PART
ajmsi-1760	396	14	study	study	VERB
ajmsi-1760	396	15	human	human	ADJ
ajmsi-1760	396	16	diseases	disease	NOUN
ajmsi-1760	396	17	(	(	PUNCT
ajmsi-1760	396	18	review	review	NOUN
ajmsi-1760	396	19	)	)	PUNCT
ajmsi-1760	396	20	.	.	PUNCT
ajmsi-1760	397	1	international	international	ADJ
ajmsi-1760	397	2	journal	journal	NOUN
ajmsi-1760	397	3	of	of	ADP
ajmsi-1760	397	4	molecular	molecular	ADJ
ajmsi-1760	397	5	medicine	medicine	NOUN
ajmsi-1760	397	6	,	,	PUNCT
ajmsi-1760	397	7	43(4	43(4	NOUN
ajmsi-1760	397	8	)	)	PUNCT
ajmsi-1760	397	9	,	,	PUNCT
ajmsi-1760	397	10	1559	1559	NUM
ajmsi-1760	397	11	-	-	SYM
ajmsi-1760	397	12	1574	1574	NUM
ajmsi-1760	397	13	.	.	PUNCT
ajmsi-1760	398	1	https://doi.org/10.3892/ijmm.2019.4112	https://doi.org/10.3892/ijmm.2019.4112	PROPN
ajmsi-1760	398	2	.	.	PUNCT
ajmsi-1760	398	3	samuelson	samuelson	PROPN
ajmsi-1760	398	4	,	,	PUNCT
ajmsi-1760	398	5	c.	c.	PROPN
ajmsi-1760	398	6	,	,	PUNCT
ajmsi-1760	398	7	radtke	radtke	NOUN
ajmsi-1760	398	8	,	,	PUNCT
ajmsi-1760	398	9	s.	s.	PROPN
ajmsi-1760	398	10	,	,	PUNCT
ajmsi-1760	398	11	zhu	zhu	PROPN
ajmsi-1760	398	12	,	,	PUNCT
ajmsi-1760	398	13	h.	h.	PROPN
ajmsi-1760	398	14	,	,	PUNCT
ajmsi-1760	398	15	llewellyn	llewellyn	PROPN
ajmsi-1760	398	16	,	,	PUNCT
ajmsi-1760	398	17	m.	m.	NOUN
ajmsi-1760	398	18	,	,	PUNCT
ajmsi-1760	398	19	fields	field	NOUN
ajmsi-1760	398	20	,	,	PUNCT
ajmsi-1760	398	21	e.	e.	PROPN
ajmsi-1760	398	22	,	,	PUNCT
ajmsi-1760	398	23	cook	cook	VERB
ajmsi-1760	398	24	,	,	PUNCT
ajmsi-1760	398	25	s.	s.	PROPN
ajmsi-1760	398	26	&	&	CCONJ
ajmsi-1760	398	27	et	et	PROPN
ajmsi-1760	398	28	al	al	PROPN
ajmsi-1760	398	29	.	.	PROPN
ajmsi-1760	399	1	(	(	PUNCT
ajmsi-1760	399	2	2021	2021	NUM
ajmsi-1760	399	3	)	)	PUNCT
ajmsi-1760	399	4	.	.	PUNCT
ajmsi-1760	400	1	multiplex	multiplex	PROPN
ajmsi-1760	400	2	crispr	crispr	PROPN
ajmsi-1760	400	3	/	/	SYM
ajmsi-1760	400	4	cas9	cas9	NOUN
ajmsi-1760	400	5	genome	genome	NOUN
ajmsi-1760	400	6	editing	editing	NOUN
ajmsi-1760	400	7	in	in	ADP
ajmsi-1760	400	8	hematopoietic	hematopoietic	ADJ
ajmsi-1760	400	9	stem	stem	NOUN
ajmsi-1760	400	10	cells	cell	NOUN
ajmsi-1760	400	11	for	for	ADP
ajmsi-1760	400	12	fetal	fetal	ADJ
ajmsi-1760	400	13	haemoglobin	haemoglobin	NOUN
ajmsi-1760	400	14	reinduction	reinduction	NOUN
ajmsi-1760	400	15	generates	generate	VERB
ajmsi-1760	400	16	chromosomal	chromosomal	ADJ
ajmsi-1760	400	17	translocations	translocation	NOUN
ajmsi-1760	400	18	.	.	PUNCT
ajmsi-1760	401	1	molecular	molecular	ADJ
ajmsi-1760	401	2	therapy	therapy	NOUN
ajmsi-1760	401	3	,	,	PUNCT
ajmsi-1760	401	4	methods	method	NOUN
ajmsi-1760	401	5	and	and	CCONJ
ajmsi-1760	401	6	clinical	clinical	ADJ
ajmsi-1760	401	7	development	development	NOUN
ajmsi-1760	401	8	,	,	PUNCT
ajmsi-1760	401	9	23	23	NUM
ajmsi-1760	401	10	,	,	PUNCT
ajmsi-1760	401	11	507–523	507–523	NUM
ajmsi-1760	401	12	.	.	PUNCT
ajmsi-1760	402	1	https://doi.org/10.1016/j	https://doi.org/10.1016/j	NOUN
ajmsi-1760	402	2	.	.	PUNCT
ajmsi-1760	403	1	omtm.2021.10.008	omtm.2021.10.008	NOUN
ajmsi-1760	403	2	.	.	PUNCT
ajmsi-1760	403	3	sharma	sharma	PROPN
ajmsi-1760	403	4	,	,	PUNCT
ajmsi-1760	403	5	g.	g.	PROPN
ajmsi-1760	403	6	,	,	PUNCT
ajmsi-1760	403	7	sharma	sharma	PROPN
ajmsi-1760	403	8	,	,	PUNCT
ajmsi-1760	403	9	a.	a.	PROPN
ajmsi-1760	403	10	r.	r.	PROPN
ajmsi-1760	403	11	,	,	PUNCT
ajmsi-1760	403	12	bhattacharya	bhattacharya	PROPN
ajmsi-1760	403	13	,	,	PUNCT
ajmsi-1760	403	14	m.	m.	NOUN
ajmsi-1760	403	15	,	,	PUNCT
ajmsi-1760	403	16	lee	lee	PROPN
ajmsi-1760	403	17	,	,	PUNCT
ajmsi-1760	403	18	s.	s.	PROPN
ajmsi-1760	403	19	s.	s.	PROPN
ajmsi-1760	403	20	&	&	CCONJ
ajmsi-1760	403	21	chakraborty	chakraborty	PROPN
ajmsi-1760	403	22	,	,	PUNCT
ajmsi-1760	403	23	c.	c.	PROPN
ajmsi-1760	403	24	(	(	PUNCT
ajmsi-1760	403	25	2021	2021	NUM
ajmsi-1760	403	26	)	)	PUNCT
ajmsi-1760	403	27	.	.	PUNCT
ajmsi-1760	404	1	crispr	crispr	NOUN
ajmsi-1760	404	2	-	-	PUNCT
ajmsi-1760	404	3	cas9	cas9	NOUN
ajmsi-1760	404	4	:	:	PUNCT
ajmsi-1760	404	5	a	a	DET
ajmsi-1760	404	6	preclinical	preclinical	ADJ
ajmsi-1760	404	7	and	and	CCONJ
ajmsi-1760	404	8	clinical	clinical	ADJ
ajmsi-1760	404	9	perspective	perspective	NOUN
ajmsi-1760	404	10	for	for	ADP
ajmsi-1760	404	11	the	the	DET
ajmsi-1760	404	12	treatment	treatment	NOUN
ajmsi-1760	404	13	of	of	ADP
ajmsi-1760	404	14	human	human	ADJ
ajmsi-1760	404	15	diseases	disease	NOUN
ajmsi-1760	404	16	.	.	PUNCT
ajmsi-1760	405	1	molecular	molecular	ADJ
ajmsi-1760	405	2	therapy	therapy	NOUN
ajmsi-1760	405	3	,	,	PUNCT
ajmsi-1760	405	4	29(2	29(2	NUM
ajmsi-1760	405	5	)	)	PUNCT
ajmsi-1760	405	6	,	,	PUNCT
ajmsi-1760	405	7	571–586	571–586	NUM
ajmsi-1760	405	8	.	.	PUNCT
ajmsi-1760	406	1	suwito	suwito	PROPN
ajmsi-1760	406	2	,	,	PUNCT
ajmsi-1760	406	3	b.	b.	PROPN
ajmsi-1760	406	4	e.	e.	PROPN
ajmsi-1760	406	5	,	,	PUNCT
ajmsi-1760	406	6	adji	adji	PROPN
ajmsi-1760	406	7	,	,	PUNCT
ajmsi-1760	406	8	a.	a.	PROPN
ajmsi-1760	406	9	s.	s.	PROPN
ajmsi-1760	406	10	,	,	PUNCT
ajmsi-1760	406	11	widjaja	widjaja	PROPN
ajmsi-1760	406	12	,	,	PUNCT
ajmsi-1760	406	13	j.	j.	PROPN
ajmsi-1760	406	14	s.	s.	PROPN
ajmsi-1760	406	15	,	,	PUNCT
ajmsi-1760	406	16	angel	angel	NOUN
ajmsi-1760	406	17	,	,	PUNCT
ajmsi-1760	406	18	s.	s.	PROPN
ajmsi-1760	406	19	c.	c.	PROPN
ajmsi-1760	406	20	s.	s.	PROPN
ajmsi-1760	406	21	,	,	PUNCT
ajmsi-1760	406	22	al	al	PROPN
ajmsi-1760	406	23	hajiri	hajiri	PROPN
ajmsi-1760	406	24	,	,	PUNCT
ajmsi-1760	406	25	a.	a.	PROPN
ajmsi-1760	406	26	z.	z.	PROPN
ajmsi-1760	406	27	z.	z.	PROPN
ajmsi-1760	406	28	&	&	CCONJ
ajmsi-1760	406	29	salamy	salamy	PROPN
ajmsi-1760	406	30	,	,	PUNCT
ajmsi-1760	406	31	n.	n.	PROPN
ajmsi-1760	406	32	f.	f.	PROPN
ajmsi-1760	406	33	w.	w.	PROPN
ajmsi-1760	406	34	(	(	PUNCT
ajmsi-1760	406	35	2023	2023	NUM
ajmsi-1760	406	36	)	)	PUNCT
ajmsi-1760	406	37	.	.	PUNCT
ajmsi-1760	407	1	a	a	DET
ajmsi-1760	407	2	review	review	NOUN
ajmsi-1760	407	3	of	of	ADP
ajmsi-1760	407	4	crispr	crispr	ADJ
ajmsi-1760	407	5	cas9	cas9	NOUN
ajmsi-1760	407	6	for	for	ADP
ajmsi-1760	407	7	sca	sca	PROPN
ajmsi-1760	407	8	:	:	PUNCT
ajmsi-1760	407	9	treatment	treatment	NOUN
ajmsi-1760	407	10	strategies	strategy	NOUN
ajmsi-1760	407	11	and	and	CCONJ
ajmsi-1760	407	12	could	could	AUX
ajmsi-1760	407	13	target	target	VERB
ajmsi-1760	407	14	β	β	ADJ
ajmsi-1760	407	15	-	-	ADJ
ajmsi-1760	407	16	globin	globin	ADJ
ajmsi-1760	407	17	gene	gene	NOUN
ajmsi-1760	407	18	and	and	CCONJ
ajmsi-1760	407	19	bcl11a	bcl11a	NUM
ajmsi-1760	407	20	gene	gene	NOUN
ajmsi-1760	407	21	using	use	VERB
ajmsi-1760	407	22	crispr	crispr	PROPN
ajmsi-1760	407	23	pa	pa	PROPN
ajmsi-1760	407	24	ge	ge	PROPN
ajmsi-1760	407	25	56	56	NUM
ajmsi-1760	407	26	https://journals.e-palli.com/home/index.php/ajmsi	https://journals.e-palli.com/home/index.php/ajmsi	PROPN
ajmsi-1760	407	27	am	be	AUX
ajmsi-1760	407	28	.	.	PUNCT
ajmsi-1760	408	1	j.	j.	PROPN
ajmsi-1760	408	2	med	med	PROPN
ajmsi-1760	408	3	.	.	PUNCT
ajmsi-1760	409	1	sci	sci	PROPN
ajmsi-1760	409	2	.	.	PUNCT
ajmsi-1760	409	3	innov	innov	PROPN
ajmsi-1760	409	4	.	.	PUNCT
ajmsi-1760	410	1	2(2	2(2	NUM
ajmsi-1760	410	2	)	)	PUNCT
ajmsi-1760	410	3	44	44	NUM
ajmsi-1760	410	4	-	-	SYM
ajmsi-1760	410	5	56	56	NUM
ajmsi-1760	410	6	,	,	PUNCT
ajmsi-1760	410	7	2023	2023	NUM
ajmsi-1760	410	8	cas9	cas9	NOUN
ajmsi-1760	410	9	prevent	prevent	VERB
ajmsi-1760	410	10	the	the	DET
ajmsi-1760	410	11	patient	patient	NOUN
ajmsi-1760	410	12	from	from	ADP
ajmsi-1760	410	13	sickle	sickle	NOUN
ajmsi-1760	410	14	cell	cell	NOUN
ajmsi-1760	410	15	anaemia	anaemia	NOUN
ajmsi-1760	410	16	?	?	PUNCT
ajmsi-1760	411	1	macedonian	macedonian	ADJ
ajmsi-1760	411	2	journal	journal	PROPN
ajmsi-1760	411	3	of	of	ADP
ajmsi-1760	411	4	medical	medical	ADJ
ajmsi-1760	411	5	sciences	science	NOUN
ajmsi-1760	411	6	,	,	PUNCT
ajmsi-1760	411	7	11(f	11(f	NUM
ajmsi-1760	411	8	)	)	PUNCT
ajmsi-1760	411	9	,	,	PUNCT
ajmsi-1760	411	10	95	95	NUM
ajmsi-1760	411	11	-	-	SYM
ajmsi-1760	411	12	106	106	NUM
ajmsi-1760	411	13	.	.	PUNCT
ajmsi-1760	412	1	https://doi.org/10.3889/oamjms.2023.11435	https://doi.org/10.3889/oamjms.2023.11435	PROPN
ajmsi-1760	412	2	.	.	PUNCT
ajmsi-1760	412	3	tasan	tasan	NOUN
ajmsi-1760	412	4	,	,	PUNCT
ajmsi-1760	412	5	i.	i.	PROPN
ajmsi-1760	412	6	,	,	PUNCT
ajmsi-1760	412	7	jain	jain	PROPN
ajmsi-1760	412	8	,	,	PUNCT
ajmsi-1760	412	9	s.	s.	PROPN
ajmsi-1760	412	10	&	&	CCONJ
ajmsi-1760	412	11	zhao	zhao	PROPN
ajmsi-1760	412	12	,	,	PUNCT
ajmsi-1760	412	13	h.	h.	PROPN
ajmsi-1760	412	14	(	(	PUNCT
ajmsi-1760	412	15	2016	2016	NUM
ajmsi-1760	412	16	)	)	PUNCT
ajmsi-1760	412	17	.	.	PUNCT
ajmsi-1760	413	1	use	use	NOUN
ajmsi-1760	413	2	of	of	ADP
ajmsi-1760	413	3	genomeediting	genomeediting	NOUN
ajmsi-1760	413	4	tools	tool	NOUN
ajmsi-1760	413	5	to	to	PART
ajmsi-1760	413	6	treat	treat	VERB
ajmsi-1760	413	7	sickle	sickle	NOUN
ajmsi-1760	413	8	cell	cell	NOUN
ajmsi-1760	413	9	disease	disease	NOUN
ajmsi-1760	413	10	.	.	PUNCT
ajmsi-1760	414	1	human	human	ADJ
ajmsi-1760	414	2	genetics	genetic	NOUN
ajmsi-1760	414	3	,	,	PUNCT
ajmsi-1760	414	4	135(9	135(9	NUM
ajmsi-1760	414	5	)	)	PUNCT
ajmsi-1760	414	6	,	,	PUNCT
ajmsi-1760	414	7	1011–1028	1011–1028	NUM
ajmsi-1760	414	8	.	.	PUNCT
ajmsi-1760	415	1	https://doi.org/10.1007/s00439016-1688-0	https://doi.org/10.1007/s00439016-1688-0	PROPN
ajmsi-1760	415	2	.	.	PUNCT
ajmsi-1760	416	1	thornburg	thornburg	PROPN
ajmsi-1760	416	2	,	,	PUNCT
ajmsi-1760	416	3	c.	c.	PROPN
ajmsi-1760	416	4	d.	d.	PROPN
ajmsi-1760	416	5	,	,	PUNCT
ajmsi-1760	416	6	files	file	NOUN
ajmsi-1760	416	7	,	,	PUNCT
ajmsi-1760	416	8	b.	b.	PROPN
ajmsi-1760	416	9	a.	a.	PROPN
ajmsi-1760	416	10	,	,	PUNCT
ajmsi-1760	416	11	luo	luo	PROPN
ajmsi-1760	416	12	,	,	PUNCT
ajmsi-1760	416	13	z.	z.	PROPN
ajmsi-1760	416	14	,	,	PUNCT
ajmsi-1760	416	15	miller	miller	PROPN
ajmsi-1760	416	16	,	,	PUNCT
ajmsi-1760	416	17	s.t	s.t	PROPN
ajmsi-1760	416	18	.	.	PROPN
ajmsi-1760	416	19	,	,	PUNCT
ajmsi-1760	416	20	kalpatthi	kalpatthi	PROPN
ajmsi-1760	416	21	,	,	PUNCT
ajmsi-1760	416	22	r.	r.	PROPN
ajmsi-1760	416	23	,	,	PUNCT
ajmsi-1760	416	24	iyer	iyer	PROPN
ajmsi-1760	416	25	,	,	PUNCT
ajmsi-1760	416	26	r.	r.	PROPN
ajmsi-1760	416	27	&	&	CCONJ
ajmsi-1760	416	28	et	et	PROPN
ajmsi-1760	416	29	al	al	PROPN
ajmsi-1760	416	30	.	.	PROPN
ajmsi-1760	417	1	(	(	PUNCT
ajmsi-1760	417	2	2012	2012	NUM
ajmsi-1760	417	3	)	)	PUNCT
ajmsi-1760	417	4	.	.	PUNCT
ajmsi-1760	418	1	impact	impact	NOUN
ajmsi-1760	418	2	of	of	ADP
ajmsi-1760	418	3	hydroxyurea	hydroxyurea	NOUN
ajmsi-1760	418	4	on	on	ADP
ajmsi-1760	418	5	clinical	clinical	ADJ
ajmsi-1760	418	6	events	event	NOUN
ajmsi-1760	418	7	in	in	ADP
ajmsi-1760	418	8	the	the	DET
ajmsi-1760	418	9	baby	baby	NOUN
ajmsi-1760	418	10	hug	hug	NOUN
ajmsi-1760	418	11	trial	trial	NOUN
ajmsi-1760	418	12	.	.	PUNCT
ajmsi-1760	419	1	blood	blood	NOUN
ajmsi-1760	419	2	,	,	PUNCT
ajmsi-1760	419	3	120(22	120(22	NUM
ajmsi-1760	419	4	)	)	PUNCT
ajmsi-1760	419	5	,	,	PUNCT
ajmsi-1760	419	6	4304	4304	NUM
ajmsi-1760	419	7	-	-	SYM
ajmsi-1760	419	8	4310	4310	NUM
ajmsi-1760	419	9	.	.	PUNCT
ajmsi-1760	420	1	https://doi.org/10.1182/	https://doi.org/10.1182/	PROPN
ajmsi-1760	420	2	blood-2012	blood-2012	NOUN
ajmsi-1760	420	3	-	-	PUNCT
ajmsi-1760	420	4	03	03	NUM
ajmsi-1760	420	5	-	-	PUNCT
ajmsi-1760	420	6	419879	419879	NUM
ajmsi-1760	420	7	.	.	PUNCT
ajmsi-1760	421	1	uchida	uchida	PROPN
ajmsi-1760	421	2	,	,	PUNCT
ajmsi-1760	421	3	n.	n.	PROPN
ajmsi-1760	421	4	,	,	PUNCT
ajmsi-1760	421	5	drysdale	drysdale	PROPN
ajmsi-1760	421	6	,	,	PUNCT
ajmsi-1760	421	7	c.	c.	PROPN
ajmsi-1760	421	8	m.	m.	PROPN
ajmsi-1760	421	9	,	,	PUNCT
ajmsi-1760	421	10	nassehi	nassehi	PROPN
ajmsi-1760	421	11	,	,	PUNCT
ajmsi-1760	421	12	t.	t.	PROPN
ajmsi-1760	421	13	,	,	PUNCT
ajmsi-1760	421	14	gamer	gamer	PROPN
ajmsi-1760	421	15	,	,	PUNCT
ajmsi-1760	421	16	j.	j.	PROPN
ajmsi-1760	421	17	,	,	PUNCT
ajmsi-1760	421	18	yapundich	yapundich	PROPN
ajmsi-1760	421	19	,	,	PUNCT
ajmsi-1760	421	20	m.	m.	NOUN
ajmsi-1760	421	21	,	,	PUNCT
ajmsi-1760	421	22	dinicola	dinicola	PROPN
ajmsi-1760	421	23	,	,	PUNCT
ajmsi-1760	421	24	j.	j.	PROPN
ajmsi-1760	421	25	&	&	CCONJ
ajmsi-1760	421	26	et	et	PROPN
ajmsi-1760	421	27	al	al	PROPN
ajmsi-1760	421	28	.	.	PROPN
ajmsi-1760	421	29	(	(	PUNCT
ajmsi-1760	421	30	2021	2021	NUM
ajmsi-1760	421	31	)	)	PUNCT
ajmsi-1760	421	32	.	.	PUNCT
ajmsi-1760	422	1	cas9	cas9	NOUN
ajmsi-1760	422	2	protein	protein	NOUN
ajmsi-1760	422	3	delivery	delivery	NOUN
ajmsi-1760	422	4	non	non	ADJ
ajmsi-1760	422	5	-	-	ADJ
ajmsi-1760	422	6	integrating	integrating	ADJ
ajmsi-1760	422	7	lentiviral	lentiviral	ADJ
ajmsi-1760	422	8	vectors	vector	NOUN
ajmsi-1760	422	9	for	for	ADP
ajmsi-1760	422	10	gene	gene	NOUN
ajmsi-1760	422	11	correction	correction	NOUN
ajmsi-1760	422	12	in	in	ADP
ajmsi-1760	422	13	sickle	sickle	NOUN
ajmsi-1760	422	14	cell	cell	NOUN
ajmsi-1760	422	15	disease	disease	NOUN
ajmsi-1760	422	16	.	.	PUNCT
ajmsi-1760	423	1	molecular	molecular	ADJ
ajmsi-1760	423	2	therapy	therapy	NOUN
ajmsi-1760	423	3	,	,	PUNCT
ajmsi-1760	423	4	methods	method	NOUN
ajmsi-1760	423	5	and	and	CCONJ
ajmsi-1760	423	6	clinical	clinical	ADJ
ajmsi-1760	423	7	development	development	NOUN
ajmsi-1760	423	8	,	,	PUNCT
ajmsi-1760	423	9	21	21	NUM
ajmsi-1760	423	10	,	,	PUNCT
ajmsi-1760	423	11	121–32	121–32	NUM
ajmsi-1760	423	12	.	.	PUNCT
ajmsi-1760	424	1	https://	https://	PROPN
ajmsi-1760	424	2	doi.org/10.1016/j.omtm.2021.02.022	doi.org/10.1016/j.omtm.2021.02.022	PROPN
ajmsi-1760	424	3	.	.	PUNCT
ajmsi-1760	425	1	uda	uda	NOUN
ajmsi-1760	425	2	,	,	PUNCT
ajmsi-1760	425	3	m.	m.	NOUN
ajmsi-1760	425	4	,	,	PUNCT
ajmsi-1760	425	5	galanello	galanello	PROPN
ajmsi-1760	425	6	,	,	PUNCT
ajmsi-1760	425	7	r.	r.	PROPN
ajmsi-1760	425	8	,	,	PUNCT
ajmsi-1760	425	9	sanna	sanna	PROPN
ajmsi-1760	425	10	,	,	PUNCT
ajmsi-1760	425	11	s.	s.	PROPN
ajmsi-1760	425	12	,	,	PUNCT
ajmsi-1760	425	13	lettre	lettre	PROPN
ajmsi-1760	425	14	,	,	PUNCT
ajmsi-1760	425	15	g.	g.	PROPN
ajmsi-1760	425	16	,	,	PUNCT
ajmsi-1760	425	17	sankaran	sankaran	VERB
ajmsi-1760	425	18	,	,	PUNCT
ajmsi-1760	425	19	v.	v.	PROPN
ajmsi-1760	425	20	g.	g.	PROPN
ajmsi-1760	425	21	,	,	PUNCT
ajmsi-1760	425	22	chen	chen	PROPN
ajmsi-1760	425	23	,	,	PUNCT
ajmsi-1760	425	24	w.	w.	PROPN
ajmsi-1760	425	25	&	&	CCONJ
ajmsi-1760	425	26	et	et	PROPN
ajmsi-1760	425	27	al	al	PROPN
ajmsi-1760	425	28	.	.	PROPN
ajmsi-1760	426	1	(	(	PUNCT
ajmsi-1760	426	2	2008	2008	NUM
ajmsi-1760	426	3	)	)	PUNCT
ajmsi-1760	426	4	.	.	PUNCT
ajmsi-1760	427	1	genome	genome	NOUN
ajmsi-1760	427	2	-	-	PUNCT
ajmsi-1760	427	3	wide	wide	ADJ
ajmsi-1760	427	4	association	association	NOUN
ajmsi-1760	427	5	study	study	NOUN
ajmsi-1760	427	6	shows	show	VERB
ajmsi-1760	427	7	bcl11a	bcl11a	PRON
ajmsi-1760	427	8	associated	associate	VERB
ajmsi-1760	427	9	with	with	ADP
ajmsi-1760	427	10	persistent	persistent	ADJ
ajmsi-1760	427	11	fetal	fetal	ADJ
ajmsi-1760	427	12	hemoglobin	hemoglobin	NOUN
ajmsi-1760	427	13	and	and	CCONJ
ajmsi-1760	427	14	amelioration	amelioration	NOUN
ajmsi-1760	427	15	of	of	ADP
ajmsi-1760	427	16	the	the	DET
ajmsi-1760	427	17	phenotype	phenotype	NOUN
ajmsi-1760	427	18	of	of	ADP
ajmsi-1760	427	19	β	β	NOUN
ajmsi-1760	427	20	-	-	NOUN
ajmsi-1760	427	21	thalassemia	thalassemia	NOUN
ajmsi-1760	427	22	.	.	PUNCT
ajmsi-1760	428	1	proceedings	proceeding	NOUN
ajmsi-1760	428	2	of	of	ADP
ajmsi-1760	428	3	the	the	DET
ajmsi-1760	428	4	national	national	PROPN
ajmsi-1760	428	5	academy	academy	PROPN
ajmsi-1760	428	6	of	of	ADP
ajmsi-1760	428	7	science	science	NOUN
ajmsi-1760	428	8	of	of	ADP
ajmsi-1760	428	9	the	the	DET
ajmsi-1760	428	10	united	united	PROPN
ajmsi-1760	428	11	states	states	PROPN
ajmsi-1760	428	12	of	of	ADP
ajmsi-1760	428	13	america	america	PROPN
ajmsi-1760	428	14	,	,	PUNCT
ajmsi-1760	428	15	105	105	NUM
ajmsi-1760	428	16	,	,	PUNCT
ajmsi-1760	428	17	1620	1620	NUM
ajmsi-1760	428	18	-	-	SYM
ajmsi-1760	428	19	1625	1625	NUM
ajmsi-1760	428	20	.	.	PUNCT
ajmsi-1760	429	1	ureña	ureña	PROPN
ajmsi-1760	429	2	-	-	PUNCT
ajmsi-1760	429	3	bailén	bailén	PROPN
ajmsi-1760	429	4	,	,	PUNCT
ajmsi-1760	429	5	g.	g.	NOUN
ajmsi-1760	429	6	,	,	PUNCT
ajmsi-1760	429	7	block	block	NOUN
ajmsi-1760	429	8	,	,	PUNCT
ajmsi-1760	429	9	m.	m.	NOUN
ajmsi-1760	429	10	,	,	PUNCT
ajmsi-1760	429	11	grandi	grandi	X
ajmsi-1760	429	12	,	,	PUNCT
ajmsi-1760	429	13	t.	t.	PROPN
ajmsi-1760	429	14	,	,	PUNCT
ajmsi-1760	429	15	aivazidou	aivazidou	PROPN
ajmsi-1760	429	16	,	,	PUNCT
ajmsi-1760	429	17	f.	f.	PROPN
ajmsi-1760	429	18	,	,	PUNCT
ajmsi-1760	429	19	quednau	quednau	PROPN
ajmsi-1760	429	20	,	,	PUNCT
ajmsi-1760	429	21	j.	j.	PROPN
ajmsi-1760	429	22	,	,	PUNCT
ajmsi-1760	429	23	krenz	krenz	PROPN
ajmsi-1760	429	24	,	,	PUNCT
ajmsi-1760	429	25	d.	d.	PROPN
ajmsi-1760	429	26	&	&	CCONJ
ajmsi-1760	429	27	et	et	PROPN
ajmsi-1760	429	28	al	al	PROPN
ajmsi-1760	429	29	.	.	PROPN
ajmsi-1760	430	1	(	(	PUNCT
ajmsi-1760	430	2	2023	2023	NUM
ajmsi-1760	430	3	)	)	PUNCT
ajmsi-1760	430	4	.	.	PUNCT
ajmsi-1760	431	1	automated	automate	VERB
ajmsi-1760	431	2	good	good	ADJ
ajmsi-1760	431	3	manufacturing	manufacturing	NOUN
ajmsi-1760	431	4	practice	practice	NOUN
ajmsi-1760	431	5	-	-	PUNCT
ajmsi-1760	431	6	compatible	compatible	ADJ
ajmsi-1760	431	7	crisprcas9	crisprcas9	NOUN
ajmsi-1760	431	8	editing	editing	NOUN
ajmsi-1760	431	9	of	of	ADP
ajmsi-1760	431	10	hematopoietic	hematopoietic	ADJ
ajmsi-1760	431	11	stem	stem	NOUN
ajmsi-1760	431	12	and	and	CCONJ
ajmsi-1760	431	13	progenitor	progenitor	NOUN
ajmsi-1760	431	14	cells	cell	NOUN
ajmsi-1760	431	15	for	for	ADP
ajmsi-1760	431	16	clinical	clinical	ADJ
ajmsi-1760	431	17	treatment	treatment	NOUN
ajmsi-1760	431	18	of	of	ADP
ajmsi-1760	431	19	β	β	NOUN
ajmsi-1760	431	20	-	-	NOUN
ajmsi-1760	431	21	hemoglobinopathies	hemoglobinopathy	NOUN
ajmsi-1760	431	22	.	.	PUNCT
ajmsi-1760	432	1	the	the	DET
ajmsi-1760	432	2	crispr	crispr	ADJ
ajmsi-1760	432	3	journal	journal	NOUN
ajmsi-1760	432	4	,	,	PUNCT
ajmsi-1760	432	5	6(1	6(1	NUM
ajmsi-1760	432	6	)	)	PUNCT
ajmsi-1760	432	7	,	,	PUNCT
ajmsi-1760	432	8	5–16	5–16	PROPN
ajmsi-1760	432	9	.	.	PUNCT
ajmsi-1760	432	10	virstyuk	virstyuk	PROPN
ajmsi-1760	432	11	,	,	PUNCT
ajmsi-1760	432	12	n.	n.	PROPN
ajmsi-1760	432	13	g.	g.	PROPN
ajmsi-1760	432	14	,	,	PUNCT
ajmsi-1760	432	15	ikwuka	ikwuka	PROPN
ajmsi-1760	432	16	,	,	PUNCT
ajmsi-1760	432	17	a.	a.	NOUN
ajmsi-1760	432	18	o.	o.	PROPN
ajmsi-1760	432	19	,	,	PUNCT
ajmsi-1760	432	20	haman	haman	PROPN
ajmsi-1760	432	21	,	,	PUNCT
ajmsi-1760	432	22	i.	i.	PROPN
ajmsi-1760	432	23	o.	o.	PROPN
ajmsi-1760	432	24	&	&	CCONJ
ajmsi-1760	432	25	adebomi	adebomi	NOUN
ajmsi-1760	432	26	,	,	PUNCT
ajmsi-1760	432	27	m.	m.	NOUN
ajmsi-1760	432	28	s.	s.	PROPN
ajmsi-1760	432	29	(	(	PUNCT
ajmsi-1760	432	30	2016	2016	NUM
ajmsi-1760	432	31	)	)	PUNCT
ajmsi-1760	432	32	.	.	PUNCT
ajmsi-1760	433	1	diabetes	diabetes	NOUN
ajmsi-1760	433	2	mellitus	mellitus	PROPN
ajmsi-1760	433	3	type	type	VERB
ajmsi-1760	433	4	2	2	NUM
ajmsi-1760	433	5	,	,	PUNCT
ajmsi-1760	433	6	arterial	arterial	ADJ
ajmsi-1760	433	7	hypertension	hypertension	NOUN
ajmsi-1760	433	8	and	and	CCONJ
ajmsi-1760	433	9	dyslipidemia	dyslipidemia	NOUN
ajmsi-1760	433	10	.	.	PUNCT
ajmsi-1760	434	1	materials	material	NOUN
ajmsi-1760	434	2	of	of	ADP
ajmsi-1760	434	3	2nd	2nd	ADJ
ajmsi-1760	434	4	international	international	ADJ
ajmsi-1760	434	5	scientific	scientific	ADJ
ajmsi-1760	434	6	and	and	CCONJ
ajmsi-1760	434	7	practical	practical	ADJ
ajmsi-1760	434	8	conference	conference	NOUN
ajmsi-1760	434	9	“	"	PUNCT
ajmsi-1760	434	10	therapeutic	therapeutic	ADJ
ajmsi-1760	434	11	readings	reading	NOUN
ajmsi-1760	434	12	:	:	PUNCT
ajmsi-1760	434	13	modern	modern	ADJ
ajmsi-1760	434	14	aspects	aspect	NOUN
ajmsi-1760	434	15	of	of	ADP
ajmsi-1760	434	16	diagnosis	diagnosis	NOUN
ajmsi-1760	434	17	and	and	CCONJ
ajmsi-1760	434	18	treatment	treatment	NOUN
ajmsi-1760	434	19	of	of	ADP
ajmsi-1760	434	20	diseases	disease	NOUN
ajmsi-1760	434	21	of	of	ADP
ajmsi-1760	434	22	internal	internal	ADJ
ajmsi-1760	434	23	organs	organ	NOUN
ajmsi-1760	434	24	”	"	PUNCT
ajmsi-1760	434	25	,	,	PUNCT
ajmsi-1760	434	26	p.	p.	NOUN
ajmsi-1760	434	27	46	46	NUM
ajmsi-1760	434	28	-	-	SYM
ajmsi-1760	434	29	47	47	NUM
ajmsi-1760	434	30	.	.	PUNCT
ajmsi-1760	435	1	virstyuk	virstyuk	NOUN
ajmsi-1760	435	2	,	,	PUNCT
ajmsi-1760	435	3	n.	n.	PROPN
ajmsi-1760	435	4	g.	g.	PROPN
ajmsi-1760	435	5	&	&	CCONJ
ajmsi-1760	435	6	ikwuka	ikwuka	PROPN
ajmsi-1760	435	7	,	,	PUNCT
ajmsi-1760	435	8	a.	a.	NOUN
ajmsi-1760	435	9	o.	o.	PROPN
ajmsi-1760	435	10	(	(	PUNCT
ajmsi-1760	435	11	2017)a	2017)a	NUM
ajmsi-1760	435	12	.	.	PUNCT
ajmsi-1760	436	1	diagnostic	diagnostic	ADJ
ajmsi-1760	436	2	and	and	CCONJ
ajmsi-1760	436	3	prognostic	prognostic	ADJ
ajmsi-1760	436	4	markers	marker	NOUN
ajmsi-1760	436	5	of	of	ADP
ajmsi-1760	436	6	the	the	DET
ajmsi-1760	436	7	diabetes	diabetes	NOUN
ajmsi-1760	436	8	mellitus	mellitus	NOUN
ajmsi-1760	436	9	type	type	VERB
ajmsi-1760	436	10	2	2	NUM
ajmsi-1760	436	11	course	course	NOUN
ajmsi-1760	436	12	in	in	ADP
ajmsi-1760	436	13	connection	connection	NOUN
ajmsi-1760	436	14	with	with	ADP
ajmsi-1760	436	15	essential	essential	ADJ
ajmsi-1760	436	16	arterial	arterial	ADJ
ajmsi-1760	436	17	hypertension	hypertension	NOUN
ajmsi-1760	436	18	taking	take	VERB
ajmsi-1760	436	19	into	into	ADP
ajmsi-1760	436	20	account	account	NOUN
ajmsi-1760	436	21	the	the	DET
ajmsi-1760	436	22	kidney	kidney	NOUN
ajmsi-1760	436	23	function	function	NOUN
ajmsi-1760	436	24	.	.	PUNCT
ajmsi-1760	437	1	precarpathian	precarpathian	ADJ
ajmsi-1760	437	2	journal	journal	PROPN
ajmsi-1760	437	3	pulse	pulse	PROPN
ajmsi-1760	437	4	,	,	PUNCT
ajmsi-1760	437	5	8(44	8(44	NUM
ajmsi-1760	437	6	)	)	PUNCT
ajmsi-1760	437	7	,	,	PUNCT
ajmsi-1760	437	8	53	53	NUM
ajmsi-1760	437	9	-	-	SYM
ajmsi-1760	437	10	62	62	NUM
ajmsi-1760	437	11	.	.	PUNCT
ajmsi-1760	438	1	virstyuk	virstyuk	NOUN
ajmsi-1760	438	2	,	,	PUNCT
ajmsi-1760	438	3	n.	n.	PROPN
ajmsi-1760	438	4	h.	h.	PROPN
ajmsi-1760	438	5	,	,	PUNCT
ajmsi-1760	438	6	ikwuka	ikwuka	PROPN
ajmsi-1760	438	7	,	,	PUNCT
ajmsi-1760	438	8	a.	a.	NOUN
ajmsi-1760	438	9	o.	o.	PROPN
ajmsi-1760	438	10	,	,	PUNCT
ajmsi-1760	438	11	losyuk	losyuk	NOUN
ajmsi-1760	438	12	,	,	PUNCT
ajmsi-1760	438	13	l.	l.	PROPN
ajmsi-1760	438	14	v.	v.	PROPN
ajmsi-1760	438	15	,	,	PUNCT
ajmsi-1760	438	16	kobrynska	kobrynska	PROPN
ajmsi-1760	438	17	,	,	PUNCT
ajmsi-1760	438	18	o.	o.	PROPN
ajmsi-1760	438	19	ya	ya	PROPN
ajmsi-1760	438	20	.	.	PROPN
ajmsi-1760	438	21	&	&	CCONJ
ajmsi-1760	438	22	markiv	markiv	PROPN
ajmsi-1760	438	23	,	,	PUNCT
ajmsi-1760	438	24	h.	h.	PROPN
ajmsi-1760	438	25	d.	d.	PROPN
ajmsi-1760	438	26	(	(	PUNCT
ajmsi-1760	439	1	2017)b	2017)b	NUM
ajmsi-1760	439	2	.	.	PUNCT
ajmsi-1760	439	3	dapagliflozin	dapagliflozin	PROPN
ajmsi-1760	439	4	utility	utility	NOUN
ajmsi-1760	439	5	in	in	ADP
ajmsi-1760	439	6	patients	patient	NOUN
ajmsi-1760	439	7	with	with	ADP
ajmsi-1760	439	8	diabetes	diabetes	NOUN
ajmsi-1760	439	9	mellitus	mellitus	NOUN
ajmsi-1760	439	10	type	type	VERB
ajmsi-1760	439	11	2	2	NUM
ajmsi-1760	439	12	and	and	CCONJ
ajmsi-1760	439	13	essential	essential	ADJ
ajmsi-1760	439	14	hypertensive	hypertensive	ADJ
ajmsi-1760	439	15	disease	disease	NOUN
ajmsi-1760	439	16	.	.	PUNCT
ajmsi-1760	440	1	actual	actual	ADJ
ajmsi-1760	440	2	problems	problem	NOUN
ajmsi-1760	440	3	of	of	ADP
ajmsi-1760	440	4	modern	modern	ADJ
ajmsi-1760	440	5	medicine	medicine	NOUN
ajmsi-1760	440	6	,	,	PUNCT
ajmsi-1760	440	7	4(60)1	4(60)1	PROPN
ajmsi-1760	440	8	,	,	PUNCT
ajmsi-1760	440	9	76	76	NUM
ajmsi-1760	440	10	-	-	SYM
ajmsi-1760	440	11	79	79	NUM
ajmsi-1760	440	12	.	.	PUNCT
ajmsi-1760	441	1	available	available	ADJ
ajmsi-1760	441	2	online	online	ADV
ajmsi-1760	441	3	:	:	PUNCT
ajmsi-1760	441	4	http://www.umsa.edu	http://www.umsa.edu	X
ajmsi-1760	441	5	.	.	PUNCT
ajmsi-1760	442	1	ua	ua	PROPN
ajmsi-1760	442	2	/	/	SYM
ajmsi-1760	442	3	journal2stat4_2017_eng.html	journal2stat4_2017_eng.html	PROPN
ajmsi-1760	442	4	virstyuk	virstyuk	NOUN
ajmsi-1760	442	5	,	,	PUNCT
ajmsi-1760	442	6	n.	n.	PROPN
ajmsi-1760	442	7	g.	g.	PROPN
ajmsi-1760	442	8	&	&	CCONJ
ajmsi-1760	442	9	ikwuka	ikwuka	PROPN
ajmsi-1760	442	10	,	,	PUNCT
ajmsi-1760	442	11	a.	a.	NOUN
ajmsi-1760	442	12	o.	o.	PROPN
ajmsi-1760	442	13	(	(	PUNCT
ajmsi-1760	442	14	2018)a	2018)a	X
ajmsi-1760	442	15	.	.	PUNCT
ajmsi-1760	442	16	features	feature	NOUN
ajmsi-1760	442	17	of	of	ADP
ajmsi-1760	442	18	asymptomatic	asymptomatic	ADJ
ajmsi-1760	442	19	hyperuricemia	hyperuricemia	NOUN
ajmsi-1760	442	20	in	in	ADP
ajmsi-1760	442	21	patients	patient	NOUN
ajmsi-1760	442	22	with	with	ADP
ajmsi-1760	442	23	diabetes	diabetes	NOUN
ajmsi-1760	442	24	mellitus	mellitus	NOUN
ajmsi-1760	442	25	type	type	VERB
ajmsi-1760	442	26	2	2	NUM
ajmsi-1760	442	27	and	and	CCONJ
ajmsi-1760	442	28	concomitant	concomitant	ADJ
ajmsi-1760	442	29	essential	essential	ADJ
ajmsi-1760	442	30	arterial	arterial	ADJ
ajmsi-1760	442	31	hypertension	hypertension	NOUN
ajmsi-1760	442	32	.	.	PUNCT
ajmsi-1760	443	1	clinical	clinical	ADJ
ajmsi-1760	443	2	and	and	CCONJ
ajmsi-1760	443	3	experimental	experimental	ADJ
ajmsi-1760	443	4	pathology	pathology	NOUN
ajmsi-1760	443	5	,	,	PUNCT
ajmsi-1760	443	6	1(63	1(63	NUM
ajmsi-1760	443	7	)	)	PUNCT
ajmsi-1760	443	8	,	,	PUNCT
ajmsi-1760	443	9	22	22	NUM
ajmsi-1760	443	10	-	-	SYM
ajmsi-1760	443	11	26	26	NUM
ajmsi-1760	443	12	.	.	PUNCT
ajmsi-1760	444	1	https://doi.org/10.24061/1727-4338	https://doi.org/10.24061/1727-4338	NOUN
ajmsi-1760	444	2	.	.	PUNCT
ajmsi-1760	445	1	xvii.1.63.2018.5	xvii.1.63.2018.5	PROPN
ajmsi-1760	445	2	.	.	PUNCT
ajmsi-1760	446	1	virstyuk	virstyuk	PROPN
ajmsi-1760	446	2	,	,	PUNCT
ajmsi-1760	446	3	n.	n.	PROPN
ajmsi-1760	446	4	g.	g.	PROPN
ajmsi-1760	446	5	,	,	PUNCT
ajmsi-1760	446	6	ikwuka	ikwuka	PROPN
ajmsi-1760	446	7	,	,	PUNCT
ajmsi-1760	446	8	a.	a.	PROPN
ajmsi-1760	446	9	o.	o.	PROPN
ajmsi-1760	446	10	&	&	CCONJ
ajmsi-1760	446	11	didushko	didushko	PROPN
ajmsi-1760	446	12	,	,	PUNCT
ajmsi-1760	446	13	o.	o.	PROPN
ajmsi-1760	446	14	m.	m.	NOUN
ajmsi-1760	446	15	(	(	PUNCT
ajmsi-1760	446	16	2018)b	2018)b	X
ajmsi-1760	446	17	.	.	X
ajmsi-1760	446	18	effect	effect	NOUN
ajmsi-1760	446	19	of	of	ADP
ajmsi-1760	446	20	dapagliflozin	dapagliflozin	PROPN
ajmsi-1760	446	21	on	on	ADP
ajmsi-1760	446	22	the	the	DET
ajmsi-1760	446	23	level	level	NOUN
ajmsi-1760	446	24	of	of	ADP
ajmsi-1760	446	25	uric	uric	ADJ
ajmsi-1760	446	26	acid	acid	NOUN
ajmsi-1760	446	27	during	during	ADP
ajmsi-1760	446	28	asymptomatic	asymptomatic	ADJ
ajmsi-1760	446	29	hyperuricemia	hyperuricemia	NOUN
ajmsi-1760	446	30	in	in	ADP
ajmsi-1760	446	31	patients	patient	NOUN
ajmsi-1760	446	32	with	with	ADP
ajmsi-1760	446	33	diabetes	diabetes	NOUN
ajmsi-1760	446	34	mellitus	mellitus	NOUN
ajmsi-1760	446	35	type	type	VERB
ajmsi-1760	446	36	2	2	NUM
ajmsi-1760	446	37	and	and	CCONJ
ajmsi-1760	446	38	concomitant	concomitant	ADJ
ajmsi-1760	446	39	arterial	arterial	ADJ
ajmsi-1760	446	40	hypertension	hypertension	NOUN
ajmsi-1760	446	41	.	.	PUNCT
ajmsi-1760	447	1	art	art	NOUN
ajmsi-1760	447	2	of	of	ADP
ajmsi-1760	447	3	medicine	medicine	NOUN
ajmsi-1760	447	4	,	,	PUNCT
ajmsi-1760	447	5	1(5	1(5	NUM
ajmsi-1760	447	6	)	)	PUNCT
ajmsi-1760	447	7	,	,	PUNCT
ajmsi-1760	447	8	21	21	NUM
ajmsi-1760	447	9	-	-	SYM
ajmsi-1760	447	10	26	26	NUM
ajmsi-1760	447	11	.	.	PUNCT
ajmsi-1760	447	12	available	available	ADJ
ajmsi-1760	447	13	online	online	ADV
ajmsi-1760	447	14	:	:	PUNCT
ajmsi-1760	447	15	https://	https://	PROPN
ajmsi-1760	447	16	art-of-medicine.ifnmu.edu.ua/index.php/aom/	art-of-medicine.ifnmu.edu.ua/index.php/aom/	PROPN
ajmsi-1760	447	17	article	article	PROPN
ajmsi-1760	447	18	/	/	SYM
ajmsi-1760	447	19	view/179/150	view/179/150	NOUN
ajmsi-1760	447	20	virstyuk	virstyuk	NOUN
ajmsi-1760	447	21	,	,	PUNCT
ajmsi-1760	447	22	n.	n.	PROPN
ajmsi-1760	447	23	h.	h.	PROPN
ajmsi-1760	447	24	&	&	CCONJ
ajmsi-1760	447	25	ikwuka	ikwuka	PROPN
ajmsi-1760	447	26	,	,	PUNCT
ajmsi-1760	447	27	a.	a.	NOUN
ajmsi-1760	447	28	o.	o.	PROPN
ajmsi-1760	447	29	(	(	PUNCT
ajmsi-1760	447	30	2018)c	2018)c	NUM
ajmsi-1760	447	31	.	.	PUNCT
ajmsi-1760	448	1	dapagliflozin	dapagliflozin	PROPN
ajmsi-1760	448	2	influence	influence	NOUN
ajmsi-1760	448	3	on	on	ADP
ajmsi-1760	448	4	the	the	DET
ajmsi-1760	448	5	clinical	clinical	ADJ
ajmsi-1760	448	6	course	course	NOUN
ajmsi-1760	448	7	of	of	ADP
ajmsi-1760	448	8	diabetes	diabetes	NOUN
ajmsi-1760	448	9	mellitus	mellitus	NOUN
ajmsi-1760	448	10	type	type	VERB
ajmsi-1760	448	11	2	2	NUM
ajmsi-1760	448	12	and	and	CCONJ
ajmsi-1760	448	13	essential	essential	ADJ
ajmsi-1760	448	14	hypertension	hypertension	NOUN
ajmsi-1760	448	15	in	in	ADP
ajmsi-1760	448	16	patients	patient	NOUN
ajmsi-1760	448	17	.	.	PUNCT
ajmsi-1760	449	1	recent	recent	ADJ
ajmsi-1760	449	2	advances	advance	NOUN
ajmsi-1760	449	3	in	in	ADP
ajmsi-1760	449	4	environmental	environmental	ADJ
ajmsi-1760	449	5	science	science	NOUN
ajmsi-1760	449	6	from	from	ADP
ajmsi-1760	449	7	the	the	DET
ajmsi-1760	449	8	euromediterranean	euromediterranean	ADJ
ajmsi-1760	449	9	and	and	CCONJ
ajmsi-1760	449	10	surrounding	surround	VERB
ajmsi-1760	449	11	regions	region	NOUN
ajmsi-1760	449	12	,	,	PUNCT
ajmsi-1760	449	13	p.	p.	NOUN
ajmsi-1760	449	14	2007	2007	NUM
ajmsi-1760	449	15	-	-	SYM
ajmsi-1760	449	16	2008	2008	NUM
ajmsi-1760	449	17	.	.	PUNCT
ajmsi-1760	450	1	https://doi.org/10.1007/978-3-319-70548-4_582	https://doi.org/10.1007/978-3-319-70548-4_582	PROPN
ajmsi-1760	450	2	.	.	PROPN
ajmsi-1760	450	3	virstyuk	virstyuk	PROPN
ajmsi-1760	450	4	,	,	PUNCT
ajmsi-1760	450	5	n.	n.	PROPN
ajmsi-1760	450	6	g.	g.	PROPN
ajmsi-1760	450	7	&	&	CCONJ
ajmsi-1760	450	8	ikwuka	ikwuka	PROPN
ajmsi-1760	450	9	,	,	PUNCT
ajmsi-1760	450	10	a.	a.	NOUN
ajmsi-1760	450	11	o.	o.	NOUN
ajmsi-1760	450	12	(	(	PUNCT
ajmsi-1760	450	13	2019	2019	NUM
ajmsi-1760	450	14	)	)	PUNCT
ajmsi-1760	450	15	.	.	PUNCT
ajmsi-1760	451	1	nephropathic	nephropathic	ADJ
ajmsi-1760	451	2	characteristics	characteristic	NOUN
ajmsi-1760	451	3	in	in	ADP
ajmsi-1760	451	4	patients	patient	NOUN
ajmsi-1760	451	5	with	with	ADP
ajmsi-1760	451	6	diabetes	diabetes	NOUN
ajmsi-1760	451	7	mellitus	mellitus	NOUN
ajmsi-1760	451	8	type	type	VERB
ajmsi-1760	451	9	2	2	NUM
ajmsi-1760	451	10	and	and	CCONJ
ajmsi-1760	451	11	essential	essential	ADJ
ajmsi-1760	451	12	hypertensive	hypertensive	ADJ
ajmsi-1760	451	13	disease	disease	NOUN
ajmsi-1760	451	14	.	.	PUNCT
ajmsi-1760	452	1	art	art	NOUN
ajmsi-1760	452	2	of	of	ADP
ajmsi-1760	452	3	medicine	medicine	NOUN
ajmsi-1760	452	4	,	,	PUNCT
ajmsi-1760	452	5	1(5	1(5	NUM
ajmsi-1760	452	6	)	)	PUNCT
ajmsi-1760	452	7	,	,	PUNCT
ajmsi-1760	452	8	44	44	NUM
ajmsi-1760	452	9	-	-	SYM
ajmsi-1760	452	10	47	47	NUM
ajmsi-1760	452	11	.	.	PUNCT
ajmsi-1760	453	1	https://doi.org/10.21802/artm.2019.1.9.44	https://doi.org/10.21802/artm.2019.1.9.44	PROPN
ajmsi-1760	453	2	.	.	PUNCT
ajmsi-1760	453	3	virstyuk	virstyuk	PROPN
ajmsi-1760	453	4	,	,	PUNCT
ajmsi-1760	453	5	n.	n.	PROPN
ajmsi-1760	453	6	g.	g.	PROPN
ajmsi-1760	453	7	&	&	CCONJ
ajmsi-1760	453	8	ikwuka	ikwuka	PROPN
ajmsi-1760	453	9	,	,	PUNCT
ajmsi-1760	453	10	a.	a.	NOUN
ajmsi-1760	453	11	o.	o.	PROPN
ajmsi-1760	453	12	(	(	PUNCT
ajmsi-1760	453	13	2021)a	2021)a	NUM
ajmsi-1760	453	14	.	.	PUNCT
ajmsi-1760	453	15	asymptomatic	asymptomatic	ADJ
ajmsi-1760	453	16	hyperuricemia	hyperuricemia	NOUN
ajmsi-1760	453	17	and	and	CCONJ
ajmsi-1760	453	18	functional	functional	ADJ
ajmsi-1760	453	19	state	state	NOUN
ajmsi-1760	453	20	of	of	ADP
ajmsi-1760	453	21	the	the	DET
ajmsi-1760	453	22	kidneys	kidney	NOUN
ajmsi-1760	453	23	in	in	ADP
ajmsi-1760	453	24	patients	patient	NOUN
ajmsi-1760	453	25	with	with	ADP
ajmsi-1760	453	26	essential	essential	ADJ
ajmsi-1760	453	27	arterial	arterial	ADJ
ajmsi-1760	453	28	hypertension	hypertension	NOUN
ajmsi-1760	453	29	and	and	CCONJ
ajmsi-1760	453	30	concomitant	concomitant	ADJ
ajmsi-1760	453	31	diabetes	diabetes	NOUN
ajmsi-1760	453	32	mellitus	mellitus	NOUN
ajmsi-1760	453	33	type	type	VERB
ajmsi-1760	453	34	2	2	NUM
ajmsi-1760	453	35	.	.	PUNCT
ajmsi-1760	453	36	european	european	ADJ
ajmsi-1760	453	37	journal	journal	PROPN
ajmsi-1760	453	38	of	of	ADP
ajmsi-1760	453	39	clinical	clinical	ADJ
ajmsi-1760	453	40	medicine	medicine	NOUN
ajmsi-1760	453	41	,	,	PUNCT
ajmsi-1760	453	42	2(3	2(3	NUM
ajmsi-1760	453	43	)	)	PUNCT
ajmsi-1760	453	44	,	,	PUNCT
ajmsi-1760	453	45	100	100	NUM
ajmsi-1760	453	46	-	-	SYM
ajmsi-1760	453	47	104	104	NUM
ajmsi-1760	453	48	.	.	PUNCT
ajmsi-1760	454	1	https://doi	https://doi	NOUN
ajmsi-1760	454	2	.	.	PUNCT
ajmsi-1760	454	3	org/10.24018	org/10.24018	PROPN
ajmsi-1760	454	4	/	/	SYM
ajmsi-1760	454	5	clinicmed.2021.2.3.65	clinicmed.2021.2.3.65	PROPN
ajmsi-1760	454	6	.	.	PUNCT
ajmsi-1760	454	7	virstyuk	virstyuk	PROPN
ajmsi-1760	454	8	,	,	PUNCT
ajmsi-1760	454	9	n.	n.	PROPN
ajmsi-1760	454	10	h.	h.	PROPN
ajmsi-1760	454	11	,	,	PUNCT
ajmsi-1760	454	12	ikwuka	ikwuka	PROPN
ajmsi-1760	454	13	,	,	PUNCT
ajmsi-1760	454	14	a.	a.	NOUN
ajmsi-1760	454	15	o.	o.	PROPN
ajmsi-1760	454	16	,	,	PUNCT
ajmsi-1760	454	17	luchko	luchko	VERB
ajmsi-1760	454	18	,	,	PUNCT
ajmsi-1760	454	19	o.	o.	PROPN
ajmsi-1760	454	20	r.	r.	PROPN
ajmsi-1760	454	21	&	&	CCONJ
ajmsi-1760	454	22	kocherzhat	kocherzhat	PROPN
ajmsi-1760	454	23	,	,	PUNCT
ajmsi-1760	454	24	o.	o.	PROPN
ajmsi-1760	454	25	i.	i.	PROPN
ajmsi-1760	454	26	(	(	PUNCT
ajmsi-1760	454	27	2021)b	2021)b	NUM
ajmsi-1760	454	28	.	.	PUNCT
ajmsi-1760	454	29	peculiarities	peculiarity	NOUN
ajmsi-1760	454	30	of	of	ADP
ajmsi-1760	454	31	renal	renal	ADJ
ajmsi-1760	454	32	insufficiency	insufficiency	NOUN
ajmsi-1760	454	33	in	in	ADP
ajmsi-1760	454	34	patients	patient	NOUN
ajmsi-1760	454	35	with	with	ADP
ajmsi-1760	454	36	diabetes	diabetes	NOUN
ajmsi-1760	454	37	mellitus	mellitus	NOUN
ajmsi-1760	454	38	type	type	VERB
ajmsi-1760	454	39	2	2	NUM
ajmsi-1760	454	40	and	and	CCONJ
ajmsi-1760	454	41	arterial	arterial	ADJ
ajmsi-1760	454	42	hypertension	hypertension	NOUN
ajmsi-1760	454	43	.	.	PUNCT
ajmsi-1760	455	1	materials	material	NOUN
ajmsi-1760	455	2	of	of	ADP
ajmsi-1760	455	3	scientificpractical	scientificpractical	ADJ
ajmsi-1760	455	4	conference	conference	NOUN
ajmsi-1760	455	5	with	with	ADP
ajmsi-1760	455	6	international	international	ADJ
ajmsi-1760	455	7	participation	participation	NOUN
ajmsi-1760	455	8	“	"	PUNCT
ajmsi-1760	455	9	achievements	achievement	NOUN
ajmsi-1760	455	10	and	and	CCONJ
ajmsi-1760	455	11	prospects	prospect	NOUN
ajmsi-1760	455	12	of	of	ADP
ajmsi-1760	455	13	experimental	experimental	ADJ
ajmsi-1760	455	14	and	and	CCONJ
ajmsi-1760	455	15	clinical	clinical	ADJ
ajmsi-1760	455	16	endocrinology	endocrinology	NOUN
ajmsi-1760	455	17	”	"	PUNCT
ajmsi-1760	455	18	twentieth	twentieth	ADJ
ajmsi-1760	455	19	danilevsky	danilevsky	NOUN
ajmsi-1760	455	20	readings	reading	NOUN
ajmsi-1760	455	21	,	,	PUNCT
ajmsi-1760	455	22	p.	p.	NOUN
ajmsi-1760	455	23	86	86	NUM
ajmsi-1760	455	24	-	-	SYM
ajmsi-1760	455	25	87	87	NUM
ajmsi-1760	455	26	.	.	PUNCT
ajmsi-1760	456	1	wen	wen	PROPN
ajmsi-1760	456	2	,	,	PUNCT
ajmsi-1760	456	3	j.	j.	PROPN
ajmsi-1760	456	4	,	,	PUNCT
ajmsi-1760	456	5	tao	tao	PROPN
ajmsi-1760	456	6	,	,	PUNCT
ajmsi-1760	456	7	w.	w.	PROPN
ajmsi-1760	456	8	,	,	PUNCT
ajmsi-1760	456	9	hao	hao	PROPN
ajmsi-1760	456	10	,	,	PUNCT
ajmsi-1760	456	11	s.	s.	PROPN
ajmsi-1760	456	12	&	&	CCONJ
ajmsi-1760	456	13	zu	zu	PROPN
ajmsi-1760	456	14	,	,	PUNCT
ajmsi-1760	456	15	y.	y.	PROPN
ajmsi-1760	456	16	(	(	PUNCT
ajmsi-1760	456	17	2017	2017	NUM
ajmsi-1760	456	18	)	)	PUNCT
ajmsi-1760	456	19	.	.	PUNCT
ajmsi-1760	457	1	cellular	cellular	ADJ
ajmsi-1760	457	2	function	function	NOUN
ajmsi-1760	457	3	reinstitution	reinstitution	NOUN
ajmsi-1760	457	4	of	of	ADP
ajmsi-1760	457	5	offspring	offspre	VERB
ajmsi-1760	457	6	red	red	ADJ
ajmsi-1760	457	7	blood	blood	NOUN
ajmsi-1760	457	8	cells	cell	NOUN
ajmsi-1760	457	9	cloned	clone	VERB
ajmsi-1760	457	10	from	from	ADP
ajmsi-1760	457	11	the	the	DET
ajmsi-1760	457	12	sickle	sickle	NOUN
ajmsi-1760	457	13	cell	cell	NOUN
ajmsi-1760	457	14	disease	disease	NOUN
ajmsi-1760	457	15	patient	patient	NOUN
ajmsi-1760	457	16	blood	blood	NOUN
ajmsi-1760	457	17	post	post	VERB
ajmsi-1760	457	18	crispr	crispr	ADJ
ajmsi-1760	457	19	genome	genome	NOUN
ajmsi-1760	457	20	editing	editing	NOUN
ajmsi-1760	457	21	.	.	PUNCT
ajmsi-1760	458	1	journal	journal	NOUN
ajmsi-1760	458	2	of	of	ADP
ajmsi-1760	458	3	hematology	hematology	PROPN
ajmsi-1760	458	4	&	&	CCONJ
ajmsi-1760	458	5	oncology	oncology	NOUN
ajmsi-1760	458	6	,	,	PUNCT
ajmsi-1760	458	7	10(1	10(1	NUM
ajmsi-1760	458	8	)	)	PUNCT
ajmsi-1760	458	9	,	,	PUNCT
ajmsi-1760	458	10	119	119	NUM
ajmsi-1760	458	11	.	.	PUNCT
ajmsi-1760	459	1	https://doi.org/10.1186/s13045-017-0489-9	https://doi.org/10.1186/s13045-017-0489-9	PROPN
ajmsi-1760	459	2	.	.	PUNCT
ajmsi-1760	460	1	world	world	PROPN
ajmsi-1760	460	2	health	health	PROPN
ajmsi-1760	460	3	organization	organization	PROPN
ajmsi-1760	460	4	.	.	PUNCT
ajmsi-1760	461	1	(	(	PUNCT
ajmsi-1760	461	2	2011	2011	NUM
ajmsi-1760	461	3	)	)	PUNCT
ajmsi-1760	461	4	.	.	PUNCT
ajmsi-1760	462	1	sickle	sickle	NOUN
ajmsi-1760	462	2	-	-	PUNCT
ajmsi-1760	462	3	cell	cell	NOUN
ajmsi-1760	462	4	disease	disease	NOUN
ajmsi-1760	462	5	and	and	CCONJ
ajmsi-1760	462	6	other	other	ADJ
ajmsi-1760	462	7	haemoglobin	haemoglobin	NOUN
ajmsi-1760	462	8	disorders	disorder	NOUN
ajmsi-1760	462	9	.	.	PUNCT
ajmsi-1760	463	1	fact	fact	NOUN
ajmsi-1760	463	2	sheet	sheet	NOUN
ajmsi-1760	463	3	no	no	INTJ
ajmsi-1760	463	4	.	.	NOUN
ajmsi-1760	464	1	308	308	NUM
ajmsi-1760	464	2	.	.	PUNCT
ajmsi-1760	464	3	available	available	ADJ
ajmsi-1760	464	4	online	online	ADV
ajmsi-1760	464	5	:	:	PUNCT
ajmsi-1760	464	6	http://www.who.int/mediacentre/	http://www.who.int/mediacentre/	NOUN
ajmsi-1760	464	7	factsheets	factsheet	NOUN
ajmsi-1760	464	8	/	/	SYM
ajmsi-1760	464	9	fs308	fs308	PROPN
ajmsi-1760	464	10	/	/	SYM
ajmsi-1760	464	11	en/	en/	NOUN
ajmsi-1760	464	12	wu	wu	PROPN
ajmsi-1760	464	13	,	,	PUNCT
ajmsi-1760	464	14	y.	y.	PROPN
ajmsi-1760	464	15	,	,	PUNCT
ajmsi-1760	464	16	zeng	zeng	PROPN
ajmsi-1760	464	17	,	,	PUNCT
ajmsi-1760	464	18	j.	j.	PROPN
ajmsi-1760	464	19	,	,	PUNCT
ajmsi-1760	464	20	roscoe	roscoe	PROPN
ajmsi-1760	464	21	,	,	PUNCT
ajmsi-1760	464	22	b.	b.	PROPN
ajmsi-1760	464	23	p.	p.	PROPN
ajmsi-1760	464	24	,	,	PUNCT
ajmsi-1760	464	25	liu	liu	PROPN
ajmsi-1760	464	26	,	,	PUNCT
ajmsi-1760	464	27	p.	p.	PROPN
ajmsi-1760	464	28	,	,	PUNCT
ajmsi-1760	464	29	yao	yao	PROPN
ajmsi-1760	464	30	,	,	PUNCT
ajmsi-1760	464	31	q.	q.	PROPN
ajmsi-1760	464	32	,	,	PUNCT
ajmsi-1760	464	33	lazzarotto	lazzarotto	ADJ
ajmsi-1760	464	34	,	,	PUNCT
ajmsi-1760	464	35	c.	c.	PROPN
ajmsi-1760	464	36	r.	r.	PROPN
ajmsi-1760	464	37	&	&	CCONJ
ajmsi-1760	464	38	et	et	PROPN
ajmsi-1760	464	39	al	al	PROPN
ajmsi-1760	464	40	.	.	PROPN
ajmsi-1760	465	1	(	(	PUNCT
ajmsi-1760	465	2	2019	2019	NUM
ajmsi-1760	465	3	)	)	PUNCT
ajmsi-1760	465	4	.	.	PUNCT
ajmsi-1760	466	1	highly	highly	ADV
ajmsi-1760	466	2	efficient	efficient	ADJ
ajmsi-1760	466	3	therapeutic	therapeutic	ADJ
ajmsi-1760	466	4	gene	gene	NOUN
ajmsi-1760	466	5	editing	editing	NOUN
ajmsi-1760	466	6	of	of	ADP
ajmsi-1760	466	7	human	human	ADJ
ajmsi-1760	466	8	hematopoietic	hematopoietic	ADJ
ajmsi-1760	466	9	stem	stem	NOUN
ajmsi-1760	466	10	cells	cell	NOUN
ajmsi-1760	466	11	.	.	PUNCT
ajmsi-1760	467	1	nature	nature	NOUN
ajmsi-1760	467	2	medicine	medicine	NOUN
ajmsi-1760	467	3	,	,	PUNCT
ajmsi-1760	467	4	25	25	NUM
ajmsi-1760	467	5	,	,	PUNCT
ajmsi-1760	467	6	776	776	NUM
ajmsi-1760	467	7	-	-	SYM
ajmsi-1760	467	8	783	783	NUM
ajmsi-1760	467	9	.	.	PUNCT
ajmsi-1760	468	1	https://doi.org/10.1038/	https://doi.org/10.1038/	PROPN
ajmsi-1760	468	2	s41591	s41591	NOUN
ajmsi-1760	468	3	-	-	PUNCT
ajmsi-1760	468	4	019	019	NUM
ajmsi-1760	468	5	-	-	PUNCT
ajmsi-1760	468	6	0401	0401	NUM
ajmsi-1760	468	7	-	-	PUNCT
ajmsi-1760	468	8	y.	y.	NOUN
ajmsi-1760	468	9	xiao	xiao	PROPN
ajmsi-1760	468	10	-	-	PUNCT
ajmsi-1760	468	11	jie	jie	PROPN
ajmsi-1760	468	12	,	,	PUNCT
ajmsi-1760	468	13	l.	l.	PROPN
ajmsi-1760	468	14	,	,	PUNCT
ajmsi-1760	468	15	hui	hui	PROPN
ajmsi-1760	468	16	-	-	PUNCT
ajmsi-1760	468	17	ying	ying	PROPN
ajmsi-1760	468	18	,	,	PUNCT
ajmsi-1760	468	19	x.	x.	PROPN
ajmsi-1760	468	20	,	,	PUNCT
ajmsi-1760	468	21	zun	zun	PROPN
ajmsi-1760	468	22	-	-	PUNCT
ajmsi-1760	468	23	ping	ping	PROPN
ajmsi-1760	468	24	,	,	PUNCT
ajmsi-1760	468	25	k.	k.	PROPN
ajmsi-1760	468	26	,	,	PUNCT
ajmsi-1760	468	27	jin	jin	NOUN
ajmsi-1760	468	28	-	-	PUNCT
ajmsi-1760	468	29	lian	lian	PROPN
ajmsi-1760	468	30	,	,	PUNCT
ajmsi-1760	468	31	c.	c.	PROPN
ajmsi-1760	468	32	&	&	CCONJ
ajmsi-1760	468	33	li	li	PROPN
ajmsi-1760	468	34	-	-	PROPN
ajmsi-1760	468	35	juan	juan	PROPN
ajmsi-1760	468	36	,	,	PUNCT
ajmsi-1760	468	37	j.	j.	PROPN
ajmsi-1760	468	38	(	(	PUNCT
ajmsi-1760	468	39	2015	2015	NUM
ajmsi-1760	468	40	)	)	PUNCT
ajmsi-1760	468	41	.	.	PUNCT
ajmsi-1760	469	1	crispr	crispr	NOUN
ajmsi-1760	469	2	-	-	PUNCT
ajmsi-1760	469	3	cas9	cas9	NOUN
ajmsi-1760	469	4	:	:	PUNCT
ajmsi-1760	469	5	a	a	DET
ajmsi-1760	469	6	new	new	ADJ
ajmsi-1760	469	7	and	and	CCONJ
ajmsi-1760	469	8	promising	promising	ADJ
ajmsi-1760	469	9	player	player	NOUN
ajmsi-1760	469	10	in	in	ADP
ajmsi-1760	469	11	gene	gene	NOUN
ajmsi-1760	469	12	therapy	therapy	NOUN
ajmsi-1760	469	13	.	.	PUNCT
ajmsi-1760	470	1	journal	journal	PROPN
ajmsi-1760	470	2	of	of	ADP
ajmsi-1760	470	3	medical	medical	ADJ
ajmsi-1760	470	4	genetics	genetic	NOUN
ajmsi-1760	470	5	,	,	PUNCT
ajmsi-1760	470	6	52(5	52(5	NUM
ajmsi-1760	470	7	)	)	PUNCT
ajmsi-1760	470	8	,	,	PUNCT
ajmsi-1760	470	9	289–296	289–296	NUM
ajmsi-1760	470	10	.	.	PUNCT
ajmsi-1760	471	1	https://doi.org/10.1136/	https://doi.org/10.1136/	ADJ
ajmsi-1760	471	2	jmedgenet-2014	jmedgenet-2014	NOUN
ajmsi-1760	471	3	-	-	PUNCT
ajmsi-1760	471	4	102968	102968	NUM
ajmsi-1760	471	5	.	.	PUNCT
ajmsi-1760	472	1	zaib	zaib	PROPN
ajmsi-1760	472	2	,	,	PUNCT
ajmsi-1760	472	3	s.	s.	PROPN
ajmsi-1760	472	4	,	,	PUNCT
ajmsi-1760	472	5	saleem	saleem	PROPN
ajmsi-1760	472	6	,	,	PUNCT
ajmsi-1760	472	7	m.	m.	NOUN
ajmsi-1760	472	8	a.	a.	PROPN
ajmsi-1760	472	9	&	&	CCONJ
ajmsi-1760	472	10	khan	khan	PROPN
ajmsi-1760	472	11	,	,	PUNCT
ajmsi-1760	472	12	i.	i.	PROPN
ajmsi-1760	472	13	(	(	PUNCT
ajmsi-1760	472	14	2022	2022	NUM
ajmsi-1760	472	15	)	)	PUNCT
ajmsi-1760	472	16	.	.	PUNCT
ajmsi-1760	473	1	crispr	crispr	ADJ
ajmsi-1760	473	2	-	-	PUNCT
ajmsi-1760	473	3	cas9	cas9	NOUN
ajmsi-1760	473	4	genome	genome	NOUN
ajmsi-1760	473	5	engineering	engineering	NOUN
ajmsi-1760	473	6	:	:	PUNCT
ajmsi-1760	473	7	trends	trend	NOUN
ajmsi-1760	473	8	in	in	ADP
ajmsi-1760	473	9	medicine	medicine	NOUN
ajmsi-1760	473	10	and	and	CCONJ
ajmsi-1760	473	11	health	health	NOUN
ajmsi-1760	473	12	.	.	PUNCT
ajmsi-1760	474	1	mini	mini	NOUN
ajmsi-1760	474	2	-	-	NOUN
ajmsi-1760	474	3	reviews	review	NOUN
ajmsi-1760	474	4	in	in	ADP
ajmsi-1760	474	5	medicinal	medicinal	ADJ
ajmsi-1760	474	6	chemistry	chemistry	NOUN
ajmsi-1760	474	7	,	,	PUNCT
ajmsi-1760	474	8	22(3	22(3	NUM
ajmsi-1760	474	9	)	)	PUNCT
ajmsi-1760	474	10	,	,	PUNCT
ajmsi-1760	474	11	410–421	410–421	NUM
ajmsi-1760	474	12	.	.	PUNCT