id	sid	tid	token	lemma	pos
ajtas-3259	1	1	american	american	PROPN
ajtas-3259	1	2	journal	journal	PROPN
ajtas-3259	1	3	of	of	ADP
ajtas-3259	1	4	technology	technology	NOUN
ajtas-3259	1	5	and	and	CCONJ
ajtas-3259	1	6	applied	apply	VERB
ajtas-3259	1	7	sciences	sciences	PROPN
ajtas-3259	1	8	issn	issn	X
ajtas-3259	1	9	(	(	PUNCT
ajtas-3259	1	10	e	e	NOUN
ajtas-3259	1	11	):	):	PUNCT
ajtas-3259	1	12	2832	2832	NUM
ajtas-3259	1	13	-	-	SYM
ajtas-3259	1	14	1766	1766	NUM
ajtas-3259	1	15	volume	volume	NOUN
ajtas-3259	1	16	43	43	NUM
ajtas-3259	1	17	,	,	PUNCT
ajtas-3259	1	18	december	december	PROPN
ajtas-3259	1	19	2025	2025	NUM
ajtas-3259	1	20	p	p	NOUN
ajtas-3259	1	21	a	a	DET
ajtas-3259	1	22	g	g	NOUN
ajtas-3259	1	23	e	e	NOUN
ajtas-3259	1	24	|	|	ADV
ajtas-3259	1	25	57	57	NUM
ajtas-3259	1	26	www.americanjournal.org	www.americanjournal.org	NOUN
ajtas-3259	1	27	chemical	chemical	NOUN
ajtas-3259	1	28	foundations	foundation	NOUN
ajtas-3259	1	29	of	of	ADP
ajtas-3259	1	30	hormone	hormone	NOUN
ajtas-3259	1	31	action	action	NOUN
ajtas-3259	1	32	and	and	CCONJ
ajtas-3259	1	33	hormonal	hormonal	ADJ
ajtas-3259	1	34	receptors	receptor	NOUN
ajtas-3259	1	35	kurbanova	kurbanova	VERB
ajtas-3259	1	36	mohira	mohira	PROPN
ajtas-3259	1	37	abduvahabovna	abduvahabovna	VERB
ajtas-3259	1	38	associate	associate	NOUN
ajtas-3259	1	39	professor	professor	NOUN
ajtas-3259	1	40	,	,	PUNCT
ajtas-3259	1	41	scientific	scientific	ADJ
ajtas-3259	1	42	supervisor	supervisor	NOUN
ajtas-3259	1	43	,	,	PUNCT
ajtas-3259	1	44	department	department	NOUN
ajtas-3259	1	45	medical	medical	ADJ
ajtas-3259	1	46	and	and	CCONJ
ajtas-3259	1	47	biological	biological	ADJ
ajtas-3259	1	48	chemistry	chemistry	NOUN
ajtas-3259	1	49	,	,	PUNCT
ajtas-3259	1	50	tashkent	tashkent	PROPN
ajtas-3259	1	51	state	state	PROPN
ajtas-3259	1	52	medical	medical	PROPN
ajtas-3259	1	53	university	university	PROPN
ajtas-3259	1	54	,	,	PUNCT
ajtas-3259	1	55	tashkent	tashkent	PROPN
ajtas-3259	1	56	,	,	PUNCT
ajtas-3259	1	57	uzbekistan	uzbekistan	PROPN
ajtas-3259	1	58	mohira_1974@mail.ru	mohira_1974@mail.ru	PROPN
ajtas-3259	1	59	hasanova	hasanova	PROPN
ajtas-3259	1	60	shakhnozakhon	shakhnozakhon	PROPN
ajtas-3259	1	61	akramovna	akramovna	VERB
ajtas-3259	1	62	student	student	NOUN
ajtas-3259	1	63	of	of	ADP
ajtas-3259	1	64	tashkent	tashkent	PROPN
ajtas-3259	1	65	state	state	PROPN
ajtas-3259	1	66	medical	medical	PROPN
ajtas-3259	1	67	university	university	PROPN
ajtas-3259	1	68	,	,	PUNCT
ajtas-3259	1	69	tashkent	tashkent	PROPN
ajtas-3259	1	70	,	,	PUNCT
ajtas-3259	1	71	uzbekistan	uzbekistan	PROPN
ajtas-3259	1	72	khasanovashakhnoza72@gmail.com	khasanovashakhnoza72@gmail.com	PROPN
ajtas-3259	2	1	a	a	DET
ajtas-3259	2	2	b	b	PROPN
ajtas-3259	2	3	s	s	ADP
ajtas-3259	2	4	t	t	PROPN
ajtas-3259	2	5	r	r	NOUN
ajtas-3259	2	6	a	a	DET
ajtas-3259	2	7	c	c	NOUN
ajtas-3259	2	8	t	t	NOUN
ajtas-3259	2	9	k	k	X
ajtas-3259	2	10	e	e	PROPN
ajtas-3259	2	11	y	y	PROPN
ajtas-3259	2	12	w	w	NOUN
ajtas-3259	2	13	o	o	NOUN
ajtas-3259	2	14	r	r	NOUN
ajtas-3259	2	15	d	d	PROPN
ajtas-3259	2	16	s	s	NOUN
ajtas-3259	2	17	hormones	hormone	NOUN
ajtas-3259	2	18	are	be	AUX
ajtas-3259	2	19	biologically	biologically	ADV
ajtas-3259	2	20	active	active	ADJ
ajtas-3259	2	21	chemical	chemical	ADJ
ajtas-3259	2	22	substances	substance	NOUN
ajtas-3259	2	23	that	that	PRON
ajtas-3259	2	24	regulate	regulate	VERB
ajtas-3259	2	25	virtually	virtually	ADV
ajtas-3259	2	26	all	all	PRON
ajtas-3259	2	27	physiological	physiological	ADJ
ajtas-3259	2	28	processes	process	NOUN
ajtas-3259	2	29	in	in	ADP
ajtas-3259	2	30	the	the	DET
ajtas-3259	2	31	human	human	ADJ
ajtas-3259	2	32	body	body	NOUN
ajtas-3259	2	33	—	—	PUNCT
ajtas-3259	2	34	including	include	VERB
ajtas-3259	2	35	growth	growth	NOUN
ajtas-3259	2	36	,	,	PUNCT
ajtas-3259	2	37	metabolism	metabolism	NOUN
ajtas-3259	2	38	,	,	PUNCT
ajtas-3259	2	39	reproduction	reproduction	NOUN
ajtas-3259	2	40	,	,	PUNCT
ajtas-3259	2	41	stress	stress	NOUN
ajtas-3259	2	42	responses	response	NOUN
ajtas-3259	2	43	,	,	PUNCT
ajtas-3259	2	44	and	and	CCONJ
ajtas-3259	2	45	the	the	DET
ajtas-3259	2	46	maintenance	maintenance	NOUN
ajtas-3259	2	47	of	of	ADP
ajtas-3259	2	48	homeostasis	homeostasis	NOUN
ajtas-3259	2	49	.	.	PUNCT
ajtas-3259	3	1	their	their	PRON
ajtas-3259	3	2	action	action	NOUN
ajtas-3259	3	3	is	be	AUX
ajtas-3259	3	4	based	base	VERB
ajtas-3259	3	5	on	on	ADP
ajtas-3259	3	6	the	the	DET
ajtas-3259	3	7	highly	highly	ADV
ajtas-3259	3	8	selective	selective	ADJ
ajtas-3259	3	9	interaction	interaction	NOUN
ajtas-3259	3	10	between	between	ADP
ajtas-3259	3	11	a	a	DET
ajtas-3259	3	12	hormone	hormone	NOUN
ajtas-3259	3	13	and	and	CCONJ
ajtas-3259	3	14	its	its	PRON
ajtas-3259	3	15	specific	specific	ADJ
ajtas-3259	3	16	receptor	receptor	NOUN
ajtas-3259	3	17	,	,	PUNCT
ajtas-3259	3	18	which	which	PRON
ajtas-3259	3	19	triggers	trigger	VERB
ajtas-3259	3	20	a	a	DET
ajtas-3259	3	21	cascade	cascade	NOUN
ajtas-3259	3	22	of	of	ADP
ajtas-3259	3	23	intracellular	intracellular	ADJ
ajtas-3259	3	24	signaling	signal	VERB
ajtas-3259	3	25	events	event	NOUN
ajtas-3259	3	26	.	.	PUNCT
ajtas-3259	4	1	this	this	DET
ajtas-3259	4	2	article	article	NOUN
ajtas-3259	4	3	examines	examine	VERB
ajtas-3259	4	4	the	the	DET
ajtas-3259	4	5	chemical	chemical	ADJ
ajtas-3259	4	6	nature	nature	NOUN
ajtas-3259	4	7	of	of	ADP
ajtas-3259	4	8	various	various	ADJ
ajtas-3259	4	9	classes	class	NOUN
ajtas-3259	4	10	of	of	ADP
ajtas-3259	4	11	hormones	hormone	NOUN
ajtas-3259	4	12	,	,	PUNCT
ajtas-3259	4	13	the	the	DET
ajtas-3259	4	14	mechanisms	mechanism	NOUN
ajtas-3259	4	15	of	of	ADP
ajtas-3259	4	16	receptor	receptor	NOUN
ajtas-3259	4	17	binding	bind	VERB
ajtas-3259	4	18	,	,	PUNCT
ajtas-3259	4	19	the	the	DET
ajtas-3259	4	20	main	main	ADJ
ajtas-3259	4	21	types	type	NOUN
ajtas-3259	4	22	of	of	ADP
ajtas-3259	4	23	hormonal	hormonal	ADJ
ajtas-3259	4	24	receptors	receptor	NOUN
ajtas-3259	4	25	,	,	PUNCT
ajtas-3259	4	26	and	and	CCONJ
ajtas-3259	4	27	the	the	DET
ajtas-3259	4	28	pathways	pathway	NOUN
ajtas-3259	4	29	of	of	ADP
ajtas-3259	4	30	intracellular	intracellular	ADJ
ajtas-3259	4	31	signal	signal	NOUN
ajtas-3259	4	32	transduction	transduction	NOUN
ajtas-3259	4	33	.	.	PUNCT
ajtas-3259	5	1	particular	particular	ADJ
ajtas-3259	5	2	attention	attention	NOUN
ajtas-3259	5	3	is	be	AUX
ajtas-3259	5	4	given	give	VERB
ajtas-3259	5	5	to	to	ADP
ajtas-3259	5	6	the	the	DET
ajtas-3259	5	7	role	role	NOUN
ajtas-3259	5	8	of	of	ADP
ajtas-3259	5	9	hormone	hormone	NOUN
ajtas-3259	5	10	–	–	PUNCT
ajtas-3259	5	11	receptor	receptor	NOUN
ajtas-3259	5	12	interactions	interaction	NOUN
ajtas-3259	5	13	in	in	ADP
ajtas-3259	5	14	metabolic	metabolic	NOUN
ajtas-3259	5	15	regulation	regulation	NOUN
ajtas-3259	5	16	,	,	PUNCT
ajtas-3259	5	17	as	as	ADV
ajtas-3259	5	18	well	well	ADV
ajtas-3259	5	19	as	as	ADP
ajtas-3259	5	20	their	their	PRON
ajtas-3259	5	21	significance	significance	NOUN
ajtas-3259	5	22	for	for	ADP
ajtas-3259	5	23	the	the	DET
ajtas-3259	5	24	diagnosis	diagnosis	NOUN
ajtas-3259	5	25	and	and	CCONJ
ajtas-3259	5	26	treatment	treatment	NOUN
ajtas-3259	5	27	of	of	ADP
ajtas-3259	5	28	endocrine	endocrine	NOUN
ajtas-3259	5	29	disorders	disorder	NOUN
ajtas-3259	5	30	.	.	PUNCT
ajtas-3259	6	1	hormones	hormone	NOUN
ajtas-3259	6	2	,	,	PUNCT
ajtas-3259	6	3	hormone	hormone	NOUN
ajtas-3259	6	4	receptors	receptor	NOUN
ajtas-3259	6	5	,	,	PUNCT
ajtas-3259	6	6	endocrine	endocrine	ADJ
ajtas-3259	6	7	system	system	NOUN
ajtas-3259	6	8	,	,	PUNCT
ajtas-3259	6	9	chemical	chemical	NOUN
ajtas-3259	6	10	structure	structure	NOUN
ajtas-3259	6	11	of	of	ADP
ajtas-3259	6	12	hormones	hormone	NOUN
ajtas-3259	6	13	,	,	PUNCT
ajtas-3259	6	14	intracellular	intracellular	ADJ
ajtas-3259	6	15	signal	signal	NOUN
ajtas-3259	6	16	transduction	transduction	NOUN
ajtas-3259	6	17	,	,	PUNCT
ajtas-3259	6	18	metabolism	metabolism	NOUN
ajtas-3259	6	19	.	.	PUNCT
ajtas-3259	7	1	introduction	introduction	NOUN
ajtas-3259	7	2	hormones	hormone	NOUN
ajtas-3259	7	3	are	be	AUX
ajtas-3259	7	4	biologically	biologically	ADV
ajtas-3259	7	5	active	active	ADJ
ajtas-3259	7	6	chemical	chemical	ADJ
ajtas-3259	7	7	substances	substance	NOUN
ajtas-3259	7	8	secreted	secrete	VERB
ajtas-3259	7	9	by	by	ADP
ajtas-3259	7	10	endocrine	endocrine	NOUN
ajtas-3259	7	11	glands	gland	NOUN
ajtas-3259	7	12	and	and	CCONJ
ajtas-3259	7	13	acting	act	VERB
ajtas-3259	7	14	on	on	ADP
ajtas-3259	7	15	distant	distant	ADJ
ajtas-3259	7	16	target	target	NOUN
ajtas-3259	7	17	organs	organ	NOUN
ajtas-3259	7	18	.	.	PUNCT
ajtas-3259	8	1	their	their	PRON
ajtas-3259	8	2	uniqueness	uniqueness	NOUN
ajtas-3259	8	3	lies	lie	VERB
ajtas-3259	8	4	in	in	ADP
ajtas-3259	8	5	their	their	PRON
ajtas-3259	8	6	high	high	ADJ
ajtas-3259	8	7	specificity	specificity	NOUN
ajtas-3259	8	8	:	:	PUNCT
ajtas-3259	8	9	each	each	DET
ajtas-3259	8	10	hormone	hormone	NOUN
ajtas-3259	8	11	affects	affect	VERB
ajtas-3259	8	12	only	only	ADV
ajtas-3259	8	13	those	those	DET
ajtas-3259	8	14	cells	cell	NOUN
ajtas-3259	8	15	that	that	PRON
ajtas-3259	8	16	contain	contain	VERB
ajtas-3259	8	17	its	its	PRON
ajtas-3259	8	18	specific	specific	ADJ
ajtas-3259	8	19	receptor	receptor	NOUN
ajtas-3259	8	20	.	.	PUNCT
ajtas-3259	9	1	understanding	understand	VERB
ajtas-3259	9	2	the	the	DET
ajtas-3259	9	3	chemical	chemical	ADJ
ajtas-3259	9	4	mechanism	mechanism	NOUN
ajtas-3259	9	5	of	of	ADP
ajtas-3259	9	6	hormone	hormone	NOUN
ajtas-3259	9	7	action	action	NOUN
ajtas-3259	9	8	is	be	AUX
ajtas-3259	9	9	crucial	crucial	ADJ
ajtas-3259	9	10	for	for	ADP
ajtas-3259	9	11	medicine	medicine	NOUN
ajtas-3259	9	12	,	,	PUNCT
ajtas-3259	9	13	as	as	SCONJ
ajtas-3259	9	14	most	most	ADJ
ajtas-3259	9	15	endocrine	endocrine	ADJ
ajtas-3259	9	16	disorders	disorder	NOUN
ajtas-3259	9	17	(	(	PUNCT
ajtas-3259	9	18	diabetes	diabetes	NOUN
ajtas-3259	9	19	mellitus	mellitus	NOUN
ajtas-3259	9	20	,	,	PUNCT
ajtas-3259	9	21	hypothyroidism	hypothyroidism	NOUN
ajtas-3259	9	22	,	,	PUNCT
ajtas-3259	9	23	cushing	cushing	NOUN
ajtas-3259	9	24	’s	’s	PART
ajtas-3259	9	25	syndrome	syndrome	NOUN
ajtas-3259	9	26	,	,	PUNCT
ajtas-3259	9	27	infertility	infertility	NOUN
ajtas-3259	9	28	)	)	PUNCT
ajtas-3259	9	29	arise	arise	VERB
ajtas-3259	9	30	from	from	ADP
ajtas-3259	9	31	dysfunction	dysfunction	NOUN
ajtas-3259	9	32	in	in	ADP
ajtas-3259	9	33	the	the	DET
ajtas-3259	9	34	hormone	hormone	NOUN
ajtas-3259	9	35	–	–	PUNCT
ajtas-3259	9	36	receptor	receptor	NOUN
ajtas-3259	9	37	interaction	interaction	NOUN
ajtas-3259	9	38	.	.	PUNCT
ajtas-3259	10	1	modern	modern	ADJ
ajtas-3259	10	2	pharmacology	pharmacology	NOUN
ajtas-3259	10	3	develops	develop	VERB
ajtas-3259	10	4	drugs	drug	NOUN
ajtas-3259	10	5	that	that	PRON
ajtas-3259	10	6	either	either	CCONJ
ajtas-3259	10	7	mimic	mimic	ADJ
ajtas-3259	10	8	natural	natural	ADJ
ajtas-3259	10	9	hormones	hormone	NOUN
ajtas-3259	10	10	or	or	CCONJ
ajtas-3259	10	11	block	block	VERB
ajtas-3259	10	12	their	their	PRON
ajtas-3259	10	13	receptors	receptor	NOUN
ajtas-3259	10	14	.	.	PUNCT
ajtas-3259	11	1	hormones	hormone	NOUN
ajtas-3259	11	2	and	and	CCONJ
ajtas-3259	11	3	their	their	PRON
ajtas-3259	11	4	receptors	receptor	NOUN
ajtas-3259	11	5	constitute	constitute	VERB
ajtas-3259	11	6	an	an	DET
ajtas-3259	11	7	extremely	extremely	ADV
ajtas-3259	11	8	precise	precise	ADJ
ajtas-3259	11	9	chemical	chemical	NOUN
ajtas-3259	11	10	system	system	NOUN
ajtas-3259	11	11	that	that	PRON
ajtas-3259	11	12	regulates	regulate	VERB
ajtas-3259	11	13	all	all	DET
ajtas-3259	11	14	vital	vital	ADJ
ajtas-3259	11	15	processes	process	NOUN
ajtas-3259	11	16	in	in	ADP
ajtas-3259	11	17	the	the	DET
ajtas-3259	11	18	body	body	NOUN
ajtas-3259	11	19	.	.	PUNCT
ajtas-3259	12	1	the	the	DET
ajtas-3259	12	2	chemical	chemical	ADJ
ajtas-3259	12	3	structure	structure	NOUN
ajtas-3259	12	4	of	of	ADP
ajtas-3259	12	5	a	a	DET
ajtas-3259	12	6	hormone	hormone	NOUN
ajtas-3259	12	7	determines	determine	VERB
ajtas-3259	12	8	its	its	PRON
ajtas-3259	12	9	ability	ability	NOUN
ajtas-3259	12	10	to	to	PART
ajtas-3259	12	11	bind	bind	VERB
ajtas-3259	12	12	to	to	ADP
ajtas-3259	12	13	a	a	DET
ajtas-3259	12	14	specific	specific	ADJ
ajtas-3259	12	15	receptor	receptor	NOUN
ajtas-3259	12	16	and	and	CCONJ
ajtas-3259	12	17	initiate	initiate	VERB
ajtas-3259	12	18	defined	define	VERB
ajtas-3259	12	19	intracellular	intracellular	ADJ
ajtas-3259	12	20	responses	response	NOUN
ajtas-3259	12	21	[	[	X
ajtas-3259	12	22	1	1	NUM
ajtas-3259	12	23	-	-	SYM
ajtas-3259	12	24	3	3	NUM
ajtas-3259	12	25	]	]	PUNCT
ajtas-3259	12	26	.	.	PUNCT
ajtas-3259	13	1	disruption	disruption	NOUN
ajtas-3259	13	2	of	of	ADP
ajtas-3259	13	3	any	any	DET
ajtas-3259	13	4	component	component	NOUN
ajtas-3259	13	5	-	-	PUNCT
ajtas-3259	13	6	hormone	hormone	NOUN
ajtas-3259	13	7	,	,	PUNCT
ajtas-3259	13	8	receptor	receptor	NOUN
ajtas-3259	13	9	,	,	PUNCT
ajtas-3259	13	10	or	or	CCONJ
ajtas-3259	13	11	signaling	signal	VERB
ajtas-3259	13	12	pathway	pathway	NOUN
ajtas-3259	13	13	-	-	PUNCT
ajtas-3259	13	14	leads	lead	NOUN
ajtas-3259	13	15	to	to	ADP
ajtas-3259	13	16	endocrine	endocrine	ADJ
ajtas-3259	13	17	pathologies	pathology	NOUN
ajtas-3259	13	18	.	.	PUNCT
ajtas-3259	14	1	understanding	understand	VERB
ajtas-3259	14	2	the	the	DET
ajtas-3259	14	3	molecular	molecular	ADJ
ajtas-3259	14	4	american	american	ADJ
ajtas-3259	14	5	journal	journal	NOUN
ajtas-3259	14	6	of	of	ADP
ajtas-3259	14	7	technology	technology	NOUN
ajtas-3259	14	8	and	and	CCONJ
ajtas-3259	14	9	applied	apply	VERB
ajtas-3259	14	10	sciences	science	NOUN
ajtas-3259	14	11	43	43	NUM
ajtas-3259	14	12	,	,	PUNCT
ajtas-3259	14	13	december	december	PROPN
ajtas-3259	14	14	2025	2025	NUM
ajtas-3259	14	15	p	p	NOUN
ajtas-3259	14	16	a	a	DET
ajtas-3259	14	17	g	g	NOUN
ajtas-3259	14	18	e	e	NOUN
ajtas-3259	14	19	|	|	ADV
ajtas-3259	14	20	58	58	NUM
ajtas-3259	14	21	www.americanjournal.org	www.americanjournal.org	NOUN
ajtas-3259	14	22	mechanisms	mechanism	NOUN
ajtas-3259	14	23	of	of	ADP
ajtas-3259	14	24	hormonal	hormonal	ADJ
ajtas-3259	14	25	action	action	NOUN
ajtas-3259	14	26	forms	form	VERB
ajtas-3259	14	27	the	the	DET
ajtas-3259	14	28	foundation	foundation	NOUN
ajtas-3259	14	29	of	of	ADP
ajtas-3259	14	30	contemporary	contemporary	ADJ
ajtas-3259	14	31	endocrinology	endocrinology	NOUN
ajtas-3259	14	32	,	,	PUNCT
ajtas-3259	14	33	pharmacology	pharmacology	NOUN
ajtas-3259	14	34	,	,	PUNCT
ajtas-3259	14	35	and	and	CCONJ
ajtas-3259	14	36	clinical	clinical	ADJ
ajtas-3259	14	37	medicine	medicine	NOUN
ajtas-3259	14	38	.	.	PUNCT
ajtas-3259	15	1	main	main	ADJ
ajtas-3259	15	2	chapters	chapter	NOUN
ajtas-3259	15	3	hormones	hormone	NOUN
ajtas-3259	15	4	can	can	AUX
ajtas-3259	15	5	be	be	AUX
ajtas-3259	15	6	divided	divide	VERB
ajtas-3259	15	7	into	into	ADP
ajtas-3259	15	8	several	several	ADJ
ajtas-3259	15	9	major	major	ADJ
ajtas-3259	15	10	classes	class	NOUN
ajtas-3259	15	11	according	accord	VERB
ajtas-3259	15	12	to	to	ADP
ajtas-3259	15	13	their	their	PRON
ajtas-3259	15	14	chemical	chemical	ADJ
ajtas-3259	15	15	nature	nature	NOUN
ajtas-3259	15	16	.	.	PUNCT
ajtas-3259	16	1	peptide	peptide	ADJ
ajtas-3259	16	2	hormones	hormone	NOUN
ajtas-3259	16	3	(	(	PUNCT
ajtas-3259	16	4	insulin	insulin	NOUN
ajtas-3259	16	5	,	,	PUNCT
ajtas-3259	16	6	vasopressin	vasopressin	NOUN
ajtas-3259	16	7	,	,	PUNCT
ajtas-3259	16	8	oxytocin	oxytocin	PROPN
ajtas-3259	16	9	)	)	PUNCT
ajtas-3259	16	10	are	be	AUX
ajtas-3259	16	11	chains	chain	NOUN
ajtas-3259	16	12	of	of	ADP
ajtas-3259	16	13	amino	amino	ADJ
ajtas-3259	16	14	acids	acid	NOUN
ajtas-3259	16	15	synthesized	synthesize	VERB
ajtas-3259	16	16	as	as	ADP
ajtas-3259	16	17	precursors	precursor	NOUN
ajtas-3259	16	18	(	(	PUNCT
ajtas-3259	16	19	proproteins	proprotein	NOUN
ajtas-3259	16	20	)	)	PUNCT
ajtas-3259	16	21	and	and	CCONJ
ajtas-3259	16	22	processed	process	VERB
ajtas-3259	16	23	post	post	NOUN
ajtas-3259	16	24	-	-	ADJ
ajtas-3259	16	25	translationally	translationally	NOUN
ajtas-3259	16	26	.	.	PUNCT
ajtas-3259	17	1	these	these	DET
ajtas-3259	17	2	hormones	hormone	NOUN
ajtas-3259	17	3	are	be	AUX
ajtas-3259	17	4	hydrophilic	hydrophilic	ADJ
ajtas-3259	17	5	and	and	CCONJ
ajtas-3259	17	6	can	can	AUX
ajtas-3259	17	7	not	not	PART
ajtas-3259	17	8	freely	freely	ADV
ajtas-3259	17	9	cross	cross	VERB
ajtas-3259	17	10	the	the	DET
ajtas-3259	17	11	lipid	lipid	ADJ
ajtas-3259	17	12	bilayer	bilayer	NOUN
ajtas-3259	17	13	of	of	ADP
ajtas-3259	17	14	the	the	DET
ajtas-3259	17	15	cell	cell	NOUN
ajtas-3259	17	16	membrane	membrane	NOUN
ajtas-3259	17	17	;	;	PUNCT
ajtas-3259	17	18	their	their	PRON
ajtas-3259	17	19	receptors	receptor	NOUN
ajtas-3259	17	20	are	be	AUX
ajtas-3259	17	21	located	locate	VERB
ajtas-3259	17	22	on	on	ADP
ajtas-3259	17	23	the	the	DET
ajtas-3259	17	24	cell	cell	NOUN
ajtas-3259	17	25	surface	surface	NOUN
ajtas-3259	17	26	and	and	CCONJ
ajtas-3259	17	27	belong	belong	VERB
ajtas-3259	17	28	to	to	ADP
ajtas-3259	17	29	families	family	NOUN
ajtas-3259	17	30	such	such	ADJ
ajtas-3259	17	31	as	as	ADP
ajtas-3259	17	32	gpcrs	gpcrs	PROPN
ajtas-3259	17	33	(	(	PUNCT
ajtas-3259	17	34	g	g	NOUN
ajtas-3259	17	35	protein	protein	NOUN
ajtas-3259	17	36	–	–	PUNCT
ajtas-3259	17	37	coupled	couple	VERB
ajtas-3259	17	38	receptors	receptor	NOUN
ajtas-3259	17	39	)	)	PUNCT
ajtas-3259	17	40	,	,	PUNCT
ajtas-3259	17	41	receptor	receptor	NOUN
ajtas-3259	17	42	tyrosine	tyrosine	NOUN
ajtas-3259	17	43	kinases	kinase	NOUN
ajtas-3259	17	44	,	,	PUNCT
ajtas-3259	17	45	and	and	CCONJ
ajtas-3259	17	46	ionotropic	ionotropic	ADJ
ajtas-3259	17	47	receptors	receptor	NOUN
ajtas-3259	17	48	.	.	PUNCT
ajtas-3259	18	1	binding	bind	VERB
ajtas-3259	18	2	of	of	ADP
ajtas-3259	18	3	a	a	DET
ajtas-3259	18	4	peptide	peptide	ADJ
ajtas-3259	18	5	hormone	hormone	NOUN
ajtas-3259	18	6	to	to	ADP
ajtas-3259	18	7	its	its	PRON
ajtas-3259	18	8	membrane	membrane	NOUN
ajtas-3259	18	9	receptor	receptor	NOUN
ajtas-3259	18	10	rapidly	rapidly	ADV
ajtas-3259	18	11	activates	activate	VERB
ajtas-3259	18	12	secondary	secondary	ADJ
ajtas-3259	18	13	messengers	messenger	NOUN
ajtas-3259	18	14	(	(	PUNCT
ajtas-3259	18	15	camp	camp	NOUN
ajtas-3259	18	16	,	,	PUNCT
ajtas-3259	18	17	ip₃/dag	ip₃/dag	PROPN
ajtas-3259	18	18	,	,	PUNCT
ajtas-3259	18	19	intracellular	intracellular	ADJ
ajtas-3259	18	20	ca²⁺	ca²⁺	NOUN
ajtas-3259	18	21	)	)	PUNCT
ajtas-3259	18	22	,	,	PUNCT
ajtas-3259	18	23	which	which	PRON
ajtas-3259	18	24	modulate	modulate	VERB
ajtas-3259	18	25	the	the	DET
ajtas-3259	18	26	activity	activity	NOUN
ajtas-3259	18	27	of	of	ADP
ajtas-3259	18	28	enzymes	enzyme	NOUN
ajtas-3259	18	29	and	and	CCONJ
ajtas-3259	18	30	ion	ion	NOUN
ajtas-3259	18	31	channels	channel	NOUN
ajtas-3259	18	32	and	and	CCONJ
ajtas-3259	18	33	ultimately	ultimately	ADV
ajtas-3259	18	34	produce	produce	VERB
ajtas-3259	18	35	a	a	DET
ajtas-3259	18	36	physiological	physiological	ADJ
ajtas-3259	18	37	response	response	NOUN
ajtas-3259	18	38	[	[	X
ajtas-3259	18	39	4	4	NUM
ajtas-3259	18	40	-	-	SYM
ajtas-3259	18	41	6	6	NUM
ajtas-3259	18	42	]	]	PUNCT
ajtas-3259	18	43	.	.	PUNCT
ajtas-3259	19	1	steroid	steroid	NOUN
ajtas-3259	19	2	hormones	hormone	NOUN
ajtas-3259	19	3	(	(	PUNCT
ajtas-3259	19	4	corticosteroids	corticosteroid	NOUN
ajtas-3259	19	5	,	,	PUNCT
ajtas-3259	19	6	androgens	androgen	NOUN
ajtas-3259	19	7	,	,	PUNCT
ajtas-3259	19	8	estrogens	estrogen	NOUN
ajtas-3259	19	9	,	,	PUNCT
ajtas-3259	19	10	progesterone	progesterone	NOUN
ajtas-3259	19	11	)	)	PUNCT
ajtas-3259	19	12	are	be	AUX
ajtas-3259	19	13	lipophilic	lipophilic	ADJ
ajtas-3259	19	14	derivatives	derivative	NOUN
ajtas-3259	19	15	of	of	ADP
ajtas-3259	19	16	cholesterol	cholesterol	NOUN
ajtas-3259	19	17	.	.	PUNCT
ajtas-3259	20	1	they	they	PRON
ajtas-3259	20	2	readily	readily	ADV
ajtas-3259	20	3	diffuse	diffuse	VERB
ajtas-3259	20	4	across	across	ADP
ajtas-3259	20	5	the	the	DET
ajtas-3259	20	6	membrane	membrane	NOUN
ajtas-3259	20	7	and	and	CCONJ
ajtas-3259	20	8	bind	bind	VERB
ajtas-3259	20	9	to	to	ADP
ajtas-3259	20	10	receptors	receptor	NOUN
ajtas-3259	20	11	in	in	ADP
ajtas-3259	20	12	the	the	DET
ajtas-3259	20	13	cytoplasm	cytoplasm	NOUN
ajtas-3259	20	14	or	or	CCONJ
ajtas-3259	20	15	nucleus	nucleus	NOUN
ajtas-3259	20	16	.	.	PUNCT
ajtas-3259	21	1	the	the	DET
ajtas-3259	21	2	resulting	result	VERB
ajtas-3259	21	3	hormone	hormone	NOUN
ajtas-3259	21	4	–	–	PUNCT
ajtas-3259	21	5	receptor	receptor	NOUN
ajtas-3259	21	6	complex	complex	NOUN
ajtas-3259	21	7	translocates	translocate	NOUN
ajtas-3259	21	8	into	into	ADP
ajtas-3259	21	9	the	the	DET
ajtas-3259	21	10	nucleus	nucleus	NOUN
ajtas-3259	21	11	,	,	PUNCT
ajtas-3259	21	12	binds	bind	VERB
ajtas-3259	21	13	to	to	ADP
ajtas-3259	21	14	regulatory	regulatory	ADJ
ajtas-3259	21	15	dna	dna	NOUN
ajtas-3259	21	16	sequences	sequence	NOUN
ajtas-3259	21	17	,	,	PUNCT
ajtas-3259	21	18	and	and	CCONJ
ajtas-3259	21	19	modulates	modulate	VERB
ajtas-3259	21	20	the	the	DET
ajtas-3259	21	21	transcription	transcription	NOUN
ajtas-3259	21	22	of	of	ADP
ajtas-3259	21	23	target	target	NOUN
ajtas-3259	21	24	genes	gene	NOUN
ajtas-3259	21	25	,	,	PUNCT
ajtas-3259	21	26	thereby	thereby	ADV
ajtas-3259	21	27	exerting	exert	VERB
ajtas-3259	21	28	long	long	ADV
ajtas-3259	21	29	-	-	PUNCT
ajtas-3259	21	30	lasting	last	VERB
ajtas-3259	21	31	effects	effect	NOUN
ajtas-3259	21	32	through	through	ADP
ajtas-3259	21	33	regulation	regulation	NOUN
ajtas-3259	21	34	of	of	ADP
ajtas-3259	21	35	protein	protein	NOUN
ajtas-3259	21	36	synthesis	synthesis	NOUN
ajtas-3259	21	37	and	and	CCONJ
ajtas-3259	21	38	functional	functional	ADJ
ajtas-3259	21	39	remodeling	remodeling	NOUN
ajtas-3259	21	40	of	of	ADP
ajtas-3259	21	41	tissues	tissue	NOUN
ajtas-3259	21	42	[	[	X
ajtas-3259	21	43	7	7	NUM
ajtas-3259	21	44	]	]	SYM
ajtas-3259	21	45	.	.	PUNCT
ajtas-3259	22	1	amine	amine	ADJ
ajtas-3259	22	2	hormones	hormone	NOUN
ajtas-3259	22	3	(	(	PUNCT
ajtas-3259	22	4	adrenaline	adrenaline	ADJ
ajtas-3259	22	5	,	,	PUNCT
ajtas-3259	22	6	noradrenaline	noradrenaline	ADJ
ajtas-3259	22	7	,	,	PUNCT
ajtas-3259	22	8	thyroxine	thyroxine	NOUN
ajtas-3259	22	9	)	)	PUNCT
ajtas-3259	22	10	are	be	AUX
ajtas-3259	22	11	derived	derive	VERB
ajtas-3259	22	12	from	from	ADP
ajtas-3259	22	13	amino	amino	ADJ
ajtas-3259	22	14	acids	acid	NOUN
ajtas-3259	22	15	(	(	PUNCT
ajtas-3259	22	16	tyrosine	tyrosine	NOUN
ajtas-3259	22	17	,	,	PUNCT
ajtas-3259	22	18	tryptophan	tryptophan	NOUN
ajtas-3259	22	19	)	)	PUNCT
ajtas-3259	22	20	.	.	PUNCT
ajtas-3259	23	1	adrenaline	adrenaline	VERB
ajtas-3259	23	2	and	and	CCONJ
ajtas-3259	23	3	noradrenaline	noradrenaline	ADJ
ajtas-3259	23	4	act	act	NOUN
ajtas-3259	23	5	predominantly	predominantly	ADV
ajtas-3259	23	6	through	through	ADP
ajtas-3259	23	7	gpcrs	gpcrs	PROPN
ajtas-3259	23	8	and	and	CCONJ
ajtas-3259	23	9	rapidly	rapidly	ADV
ajtas-3259	23	10	regulate	regulate	VERB
ajtas-3259	23	11	vascular	vascular	ADJ
ajtas-3259	23	12	tone	tone	NOUN
ajtas-3259	23	13	,	,	PUNCT
ajtas-3259	23	14	heart	heart	NOUN
ajtas-3259	23	15	rate	rate	NOUN
ajtas-3259	23	16	,	,	PUNCT
ajtas-3259	23	17	and	and	CCONJ
ajtas-3259	23	18	metabolism	metabolism	NOUN
ajtas-3259	23	19	.	.	PUNCT
ajtas-3259	24	1	thyroxine	thyroxine	NOUN
ajtas-3259	24	2	(	(	PUNCT
ajtas-3259	24	3	t₄	t₄	NOUN
ajtas-3259	24	4	)	)	PUNCT
ajtas-3259	24	5	and	and	CCONJ
ajtas-3259	24	6	triiodothyronine	triiodothyronine	NOUN
ajtas-3259	24	7	(	(	PUNCT
ajtas-3259	24	8	t₃	t₃	NOUN
ajtas-3259	24	9	)	)	PUNCT
ajtas-3259	24	10	exhibit	exhibit	NOUN
ajtas-3259	24	11	properties	property	NOUN
ajtas-3259	24	12	similar	similar	ADJ
ajtas-3259	24	13	to	to	ADP
ajtas-3259	24	14	steroid	steroid	NOUN
ajtas-3259	24	15	hormones	hormone	NOUN
ajtas-3259	24	16	:	:	PUNCT
ajtas-3259	24	17	they	they	PRON
ajtas-3259	24	18	circulate	circulate	VERB
ajtas-3259	24	19	in	in	ADP
ajtas-3259	24	20	protein	protein	NOUN
ajtas-3259	24	21	-	-	PUNCT
ajtas-3259	24	22	bound	bind	VERB
ajtas-3259	24	23	form	form	NOUN
ajtas-3259	24	24	and	and	CCONJ
ajtas-3259	24	25	act	act	VERB
ajtas-3259	24	26	via	via	ADP
ajtas-3259	24	27	nuclear	nuclear	ADJ
ajtas-3259	24	28	receptors	receptor	NOUN
ajtas-3259	24	29	,	,	PUNCT
ajtas-3259	24	30	regulating	regulate	VERB
ajtas-3259	24	31	the	the	DET
ajtas-3259	24	32	transcription	transcription	NOUN
ajtas-3259	24	33	of	of	ADP
ajtas-3259	24	34	genes	gene	NOUN
ajtas-3259	24	35	responsible	responsible	ADJ
ajtas-3259	24	36	for	for	ADP
ajtas-3259	24	37	basal	basal	ADJ
ajtas-3259	24	38	metabolic	metabolic	NOUN
ajtas-3259	24	39	rate	rate	NOUN
ajtas-3259	24	40	[	[	X
ajtas-3259	24	41	8	8	NUM
ajtas-3259	24	42	]	]	PUNCT
ajtas-3259	24	43	.	.	PUNCT
ajtas-3259	25	1	eicosanoids	eicosanoid	NOUN
ajtas-3259	25	2	(	(	PUNCT
ajtas-3259	25	3	prostaglandins	prostaglandin	NOUN
ajtas-3259	25	4	,	,	PUNCT
ajtas-3259	25	5	thromboxanes	thromboxane	NOUN
ajtas-3259	25	6	,	,	PUNCT
ajtas-3259	25	7	leukotrienes	leukotriene	NOUN
ajtas-3259	25	8	)	)	PUNCT
ajtas-3259	25	9	are	be	AUX
ajtas-3259	25	10	local	local	ADJ
ajtas-3259	25	11	lipid	lipid	NOUN
ajtas-3259	25	12	mediators	mediator	NOUN
ajtas-3259	25	13	derived	derive	VERB
ajtas-3259	25	14	from	from	ADP
ajtas-3259	25	15	arachidonic	arachidonic	ADJ
ajtas-3259	25	16	acid	acid	NOUN
ajtas-3259	25	17	.	.	PUNCT
ajtas-3259	26	1	they	they	PRON
ajtas-3259	26	2	have	have	VERB
ajtas-3259	26	3	a	a	DET
ajtas-3259	26	4	short	short	ADJ
ajtas-3259	26	5	half	half	ADJ
ajtas-3259	26	6	-	-	PUNCT
ajtas-3259	26	7	life	life	NOUN
ajtas-3259	26	8	and	and	CCONJ
ajtas-3259	26	9	act	act	VERB
ajtas-3259	26	10	through	through	ADP
ajtas-3259	26	11	membrane	membrane	NOUN
ajtas-3259	26	12	receptors	receptor	NOUN
ajtas-3259	26	13	to	to	PART
ajtas-3259	26	14	rapidly	rapidly	ADV
ajtas-3259	26	15	regulate	regulate	VERB
ajtas-3259	26	16	inflammatory	inflammatory	ADJ
ajtas-3259	26	17	and	and	CCONJ
ajtas-3259	26	18	vascular	vascular	ADJ
ajtas-3259	26	19	responses	response	NOUN
ajtas-3259	26	20	.	.	PUNCT
ajtas-3259	27	1	fig.1.hormone	fig.1.hormone	ADJ
ajtas-3259	27	2	types	type	NOUN
ajtas-3259	27	3	and	and	CCONJ
ajtas-3259	27	4	their	their	PRON
ajtas-3259	27	5	receptor	receptor	NOUN
ajtas-3259	27	6	diversity	diversity	NOUN
ajtas-3259	27	7	american	american	PROPN
ajtas-3259	27	8	journal	journal	PROPN
ajtas-3259	27	9	of	of	ADP
ajtas-3259	27	10	technology	technology	NOUN
ajtas-3259	27	11	and	and	CCONJ
ajtas-3259	27	12	applied	apply	VERB
ajtas-3259	27	13	sciences	science	NOUN
ajtas-3259	27	14	43	43	NUM
ajtas-3259	27	15	,	,	PUNCT
ajtas-3259	27	16	december	december	PROPN
ajtas-3259	27	17	2025	2025	NUM
ajtas-3259	28	1	p	p	NOUN
ajtas-3259	28	2	a	a	DET
ajtas-3259	28	3	g	g	NOUN
ajtas-3259	28	4	e	e	NOUN
ajtas-3259	28	5	|	|	ADV
ajtas-3259	28	6	59	59	NUM
ajtas-3259	28	7	www.americanjournal.org	www.americanjournal.org	PROPN
ajtas-3259	28	8	signal	signal	NOUN
ajtas-3259	28	9	transduction	transduction	NOUN
ajtas-3259	28	10	mechanisms	mechanism	NOUN
ajtas-3259	28	11	include	include	VERB
ajtas-3259	28	12	activation	activation	NOUN
ajtas-3259	28	13	of	of	ADP
ajtas-3259	28	14	adenylyl	adenylyl	ADJ
ajtas-3259	28	15	cyclase	cyclase	NOUN
ajtas-3259	28	16	with	with	ADP
ajtas-3259	28	17	subsequent	subsequent	ADJ
ajtas-3259	28	18	camp	camp	NOUN
ajtas-3259	28	19	production	production	NOUN
ajtas-3259	28	20	and	and	CCONJ
ajtas-3259	28	21	activation	activation	NOUN
ajtas-3259	28	22	of	of	ADP
ajtas-3259	28	23	protein	protein	NOUN
ajtas-3259	28	24	kinase	kinase	NOUN
ajtas-3259	28	25	a	a	DET
ajtas-3259	28	26	(	(	PUNCT
ajtas-3259	28	27	pka	pka	NOUN
ajtas-3259	28	28	)	)	PUNCT
ajtas-3259	28	29	;	;	PUNCT
ajtas-3259	28	30	activation	activation	NOUN
ajtas-3259	28	31	of	of	ADP
ajtas-3259	28	32	phospholipase	phospholipase	NOUN
ajtas-3259	28	33	c	c	PROPN
ajtas-3259	28	34	leading	lead	VERB
ajtas-3259	28	35	to	to	ADP
ajtas-3259	28	36	the	the	DET
ajtas-3259	28	37	formation	formation	NOUN
ajtas-3259	28	38	of	of	ADP
ajtas-3259	28	39	ip₃	ip₃	PROPN
ajtas-3259	28	40	and	and	CCONJ
ajtas-3259	28	41	dag	dag	PROPN
ajtas-3259	28	42	(	(	PUNCT
ajtas-3259	28	43	ip₃	ip₃	PROPN
ajtas-3259	28	44	induces	induce	VERB
ajtas-3259	28	45	ca²⁺	ca²⁺	PROPN
ajtas-3259	28	46	release	release	NOUN
ajtas-3259	28	47	from	from	ADP
ajtas-3259	28	48	the	the	DET
ajtas-3259	28	49	endoplasmic	endoplasmic	ADJ
ajtas-3259	28	50	reticulum	reticulum	NOUN
ajtas-3259	28	51	,	,	PUNCT
ajtas-3259	28	52	while	while	SCONJ
ajtas-3259	28	53	dag	dag	PROPN
ajtas-3259	28	54	activates	activate	VERB
ajtas-3259	28	55	pkc	pkc	PROPN
ajtas-3259	28	56	)	)	PUNCT
ajtas-3259	28	57	;	;	PUNCT
ajtas-3259	28	58	as	as	ADV
ajtas-3259	28	59	well	well	ADV
ajtas-3259	28	60	as	as	ADP
ajtas-3259	28	61	direct	direct	ADJ
ajtas-3259	28	62	tyrosine	tyrosine	NOUN
ajtas-3259	28	63	kinase	kinase	PROPN
ajtas-3259	28	64	activity	activity	NOUN
ajtas-3259	28	65	(	(	PUNCT
ajtas-3259	28	66	phosphorylation	phosphorylation	NOUN
ajtas-3259	28	67	of	of	ADP
ajtas-3259	28	68	target	target	NOUN
ajtas-3259	28	69	proteins	protein	NOUN
ajtas-3259	28	70	)	)	PUNCT
ajtas-3259	28	71	and	and	CCONJ
ajtas-3259	28	72	proteolysis	proteolysis	NOUN
ajtas-3259	28	73	/	/	SYM
ajtas-3259	28	74	modification	modification	NOUN
ajtas-3259	28	75	of	of	ADP
ajtas-3259	28	76	transcription	transcription	NOUN
ajtas-3259	28	77	factors	factor	NOUN
ajtas-3259	28	78	.	.	PUNCT
ajtas-3259	29	1	the	the	DET
ajtas-3259	29	2	final	final	ADJ
ajtas-3259	29	3	cellular	cellular	ADJ
ajtas-3259	29	4	response	response	NOUN
ajtas-3259	29	5	depends	depend	VERB
ajtas-3259	29	6	on	on	ADP
ajtas-3259	29	7	context	context	NOUN
ajtas-3259	29	8	:	:	PUNCT
ajtas-3259	29	9	receptor	receptor	NOUN
ajtas-3259	29	10	type	type	NOUN
ajtas-3259	29	11	,	,	PUNCT
ajtas-3259	29	12	availability	availability	NOUN
ajtas-3259	29	13	of	of	ADP
ajtas-3259	29	14	secondary	secondary	ADJ
ajtas-3259	29	15	messengers	messenger	NOUN
ajtas-3259	29	16	,	,	PUNCT
ajtas-3259	29	17	cross	cross	ADJ
ajtas-3259	29	18	-	-	ADJ
ajtas-3259	29	19	regulatory	regulatory	ADJ
ajtas-3259	29	20	mechanisms	mechanism	NOUN
ajtas-3259	29	21	,	,	PUNCT
ajtas-3259	29	22	and	and	CCONJ
ajtas-3259	29	23	the	the	DET
ajtas-3259	29	24	expression	expression	NOUN
ajtas-3259	29	25	level	level	NOUN
ajtas-3259	29	26	of	of	ADP
ajtas-3259	29	27	receptor	receptor	NOUN
ajtas-3259	29	28	isoforms	isoform	NOUN
ajtas-3259	29	29	.	.	PUNCT
ajtas-3259	30	1	pathology	pathology	NOUN
ajtas-3259	30	2	within	within	ADP
ajtas-3259	30	3	the	the	DET
ajtas-3259	30	4	hormone	hormone	NOUN
ajtas-3259	30	5	–	–	PUNCT
ajtas-3259	30	6	receptor	receptor	NOUN
ajtas-3259	30	7	system	system	NOUN
ajtas-3259	30	8	may	may	AUX
ajtas-3259	30	9	be	be	AUX
ajtas-3259	30	10	associated	associate	VERB
ajtas-3259	30	11	with	with	ADP
ajtas-3259	30	12	insufficient	insufficient	ADJ
ajtas-3259	30	13	hormone	hormone	NOUN
ajtas-3259	30	14	secretion	secretion	NOUN
ajtas-3259	30	15	(	(	PUNCT
ajtas-3259	30	16	primary	primary	ADJ
ajtas-3259	30	17	deficiency	deficiency	NOUN
ajtas-3259	30	18	)	)	PUNCT
ajtas-3259	30	19	,	,	PUNCT
ajtas-3259	30	20	excessive	excessive	ADJ
ajtas-3259	30	21	secretion	secretion	NOUN
ajtas-3259	30	22	(	(	PUNCT
ajtas-3259	30	23	adenomas	adenoma	NOUN
ajtas-3259	30	24	)	)	PUNCT
ajtas-3259	30	25	,	,	PUNCT
ajtas-3259	30	26	receptor	receptor	NOUN
ajtas-3259	30	27	defects	defect	NOUN
ajtas-3259	30	28	(	(	PUNCT
ajtas-3259	30	29	hormone	hormone	NOUN
ajtas-3259	30	30	resistance	resistance	NOUN
ajtas-3259	30	31	)	)	PUNCT
ajtas-3259	30	32	,	,	PUNCT
ajtas-3259	30	33	or	or	CCONJ
ajtas-3259	30	34	impairments	impairment	NOUN
ajtas-3259	30	35	in	in	ADP
ajtas-3259	30	36	post	post	ADJ
ajtas-3259	30	37	-	-	ADJ
ajtas-3259	30	38	receptor	receptor	NOUN
ajtas-3259	30	39	signaling	signal	VERB
ajtas-3259	30	40	pathways	pathway	NOUN
ajtas-3259	30	41	(	(	PUNCT
ajtas-3259	30	42	secondary	secondary	ADJ
ajtas-3259	30	43	messenger	messenger	NOUN
ajtas-3259	30	44	abnormalities	abnormality	NOUN
ajtas-3259	30	45	)	)	PUNCT
ajtas-3259	30	46	.	.	PUNCT
ajtas-3259	31	1	a	a	DET
ajtas-3259	31	2	classical	classical	ADJ
ajtas-3259	31	3	example	example	NOUN
ajtas-3259	31	4	is	be	AUX
ajtas-3259	31	5	insulin	insulin	NOUN
ajtas-3259	31	6	resistance	resistance	NOUN
ajtas-3259	31	7	in	in	ADP
ajtas-3259	31	8	type	type	NOUN
ajtas-3259	31	9	2	2	NUM
ajtas-3259	31	10	diabetes	diabetes	NOUN
ajtas-3259	31	11	mellitus	mellitus	NOUN
ajtas-3259	31	12	,	,	PUNCT
ajtas-3259	31	13	in	in	ADP
ajtas-3259	31	14	which	which	PRON
ajtas-3259	31	15	normal	normal	ADJ
ajtas-3259	31	16	or	or	CCONJ
ajtas-3259	31	17	elevated	elevated	ADJ
ajtas-3259	31	18	insulin	insulin	NOUN
ajtas-3259	31	19	levels	level	NOUN
ajtas-3259	31	20	fail	fail	VERB
ajtas-3259	31	21	to	to	PART
ajtas-3259	31	22	produce	produce	VERB
ajtas-3259	31	23	adequate	adequate	ADJ
ajtas-3259	31	24	glucose	glucose	NOUN
ajtas-3259	31	25	uptake	uptake	ADJ
ajtas-3259	31	26	due	due	ADJ
ajtas-3259	31	27	to	to	ADP
ajtas-3259	31	28	defects	defect	NOUN
ajtas-3259	31	29	in	in	ADP
ajtas-3259	31	30	the	the	DET
ajtas-3259	31	31	insulin	insulin	NOUN
ajtas-3259	31	32	receptor	receptor	NOUN
ajtas-3259	31	33	or	or	CCONJ
ajtas-3259	31	34	downstream	downstream	ADJ
ajtas-3259	31	35	signaling	signal	VERB
ajtas-3259	31	36	pathways	pathway	NOUN
ajtas-3259	31	37	(	(	PUNCT
ajtas-3259	31	38	pi3k	pi3k	NOUN
ajtas-3259	31	39	/	/	SYM
ajtas-3259	31	40	akt	akt	PROPN
ajtas-3259	31	41	)	)	PUNCT
ajtas-3259	32	1	[	[	X
ajtas-3259	32	2	9	9	NUM
ajtas-3259	32	3	]	]	PUNCT
ajtas-3259	32	4	.	.	PUNCT
ajtas-3259	33	1	clinical	clinical	ADJ
ajtas-3259	33	2	applications	application	NOUN
ajtas-3259	33	3	of	of	ADP
ajtas-3259	33	4	knowledge	knowledge	NOUN
ajtas-3259	33	5	about	about	ADP
ajtas-3259	33	6	hormone	hormone	NOUN
ajtas-3259	33	7	–	–	PUNCT
ajtas-3259	33	8	receptor	receptor	NOUN
ajtas-3259	33	9	interactions	interaction	NOUN
ajtas-3259	33	10	include	include	VERB
ajtas-3259	33	11	replacement	replacement	NOUN
ajtas-3259	33	12	therapy	therapy	NOUN
ajtas-3259	33	13	(	(	PUNCT
ajtas-3259	33	14	insulin	insulin	NOUN
ajtas-3259	33	15	therapy	therapy	NOUN
ajtas-3259	33	16	,	,	PUNCT
ajtas-3259	33	17	thyroxine	thyroxine	NOUN
ajtas-3259	33	18	replacement	replacement	NOUN
ajtas-3259	33	19	)	)	PUNCT
ajtas-3259	33	20	,	,	PUNCT
ajtas-3259	33	21	the	the	DET
ajtas-3259	33	22	use	use	NOUN
ajtas-3259	33	23	of	of	ADP
ajtas-3259	33	24	receptor	receptor	NOUN
ajtas-3259	33	25	agonists	agonist	NOUN
ajtas-3259	33	26	and	and	CCONJ
ajtas-3259	33	27	antagonists	antagonist	NOUN
ajtas-3259	33	28	(	(	PUNCT
ajtas-3259	33	29	β	β	NOUN
ajtas-3259	33	30	-	-	NOUN
ajtas-3259	33	31	blockers	blocker	NOUN
ajtas-3259	33	32	,	,	PUNCT
ajtas-3259	33	33	antiestrogens	antiestrogen	NOUN
ajtas-3259	33	34	,	,	PUNCT
ajtas-3259	33	35	angiotensin	angiotensin	NOUN
ajtas-3259	33	36	ii	ii	PROPN
ajtas-3259	33	37	antagonists	antagonist	NOUN
ajtas-3259	33	38	)	)	PUNCT
ajtas-3259	33	39	,	,	PUNCT
ajtas-3259	33	40	as	as	ADV
ajtas-3259	33	41	well	well	ADV
ajtas-3259	33	42	as	as	ADP
ajtas-3259	33	43	hormone	hormone	NOUN
ajtas-3259	33	44	-	-	PUNCT
ajtas-3259	33	45	based	base	VERB
ajtas-3259	33	46	therapy	therapy	NOUN
ajtas-3259	33	47	in	in	ADP
ajtas-3259	33	48	oncology	oncology	NOUN
ajtas-3259	33	49	(	(	PUNCT
ajtas-3259	33	50	aromatase	aromatase	ADJ
ajtas-3259	33	51	inhibitors	inhibitor	NOUN
ajtas-3259	33	52	in	in	ADP
ajtas-3259	33	53	estrogen	estrogen	NOUN
ajtas-3259	33	54	-	-	PUNCT
ajtas-3259	33	55	dependent	dependent	ADJ
ajtas-3259	33	56	breast	breast	NOUN
ajtas-3259	33	57	cancer	cancer	NOUN
ajtas-3259	33	58	)	)	PUNCT
ajtas-3259	33	59	.	.	PUNCT
ajtas-3259	34	1	modern	modern	ADJ
ajtas-3259	34	2	approaches	approach	NOUN
ajtas-3259	34	3	also	also	ADV
ajtas-3259	34	4	involve	involve	VERB
ajtas-3259	34	5	the	the	DET
ajtas-3259	34	6	development	development	NOUN
ajtas-3259	34	7	of	of	ADP
ajtas-3259	34	8	small	small	ADJ
ajtas-3259	34	9	-	-	PUNCT
ajtas-3259	34	10	molecule	molecule	NOUN
ajtas-3259	34	11	and	and	CCONJ
ajtas-3259	34	12	biological	biological	ADJ
ajtas-3259	34	13	agents	agent	NOUN
ajtas-3259	34	14	targeting	target	VERB
ajtas-3259	34	15	components	component	NOUN
ajtas-3259	34	16	of	of	ADP
ajtas-3259	34	17	signaling	signal	VERB
ajtas-3259	34	18	cascades	cascade	NOUN
ajtas-3259	34	19	(	(	PUNCT
ajtas-3259	34	20	tyrosine	tyrosine	NOUN
ajtas-3259	34	21	kinase	kinase	PROPN
ajtas-3259	34	22	inhibitors	inhibitor	NOUN
ajtas-3259	34	23	,	,	PUNCT
ajtas-3259	34	24	monoclonal	monoclonal	NOUN
ajtas-3259	34	25	antibodies	antibody	NOUN
ajtas-3259	34	26	)	)	PUNCT
ajtas-3259	34	27	.	.	PUNCT
ajtas-3259	35	1	in	in	ADP
ajtas-3259	35	2	conclusion	conclusion	NOUN
ajtas-3259	35	3	,	,	PUNCT
ajtas-3259	35	4	the	the	DET
ajtas-3259	35	5	chemical	chemical	ADJ
ajtas-3259	35	6	structure	structure	NOUN
ajtas-3259	35	7	of	of	ADP
ajtas-3259	35	8	hormones	hormone	NOUN
ajtas-3259	35	9	determines	determine	VERB
ajtas-3259	35	10	their	their	PRON
ajtas-3259	35	11	transport	transport	NOUN
ajtas-3259	35	12	pathways	pathway	NOUN
ajtas-3259	35	13	,	,	PUNCT
ajtas-3259	35	14	receptor	receptor	NOUN
ajtas-3259	35	15	localization	localization	NOUN
ajtas-3259	35	16	,	,	PUNCT
ajtas-3259	35	17	and	and	CCONJ
ajtas-3259	35	18	mechanisms	mechanism	NOUN
ajtas-3259	35	19	of	of	ADP
ajtas-3259	35	20	signal	signal	ADJ
ajtas-3259	35	21	transduction	transduction	NOUN
ajtas-3259	35	22	.	.	PUNCT
ajtas-3259	36	1	the	the	DET
ajtas-3259	36	2	distinctions	distinction	NOUN
ajtas-3259	36	3	between	between	ADP
ajtas-3259	36	4	hydrophilic	hydrophilic	ADJ
ajtas-3259	36	5	and	and	CCONJ
ajtas-3259	36	6	lipophilic	lipophilic	ADJ
ajtas-3259	36	7	hormones	hormone	NOUN
ajtas-3259	36	8	underpin	underpin	VERB
ajtas-3259	36	9	fundamentally	fundamentally	ADV
ajtas-3259	36	10	different	different	ADJ
ajtas-3259	36	11	modes	mode	NOUN
ajtas-3259	36	12	of	of	ADP
ajtas-3259	36	13	action	action	NOUN
ajtas-3259	36	14	—	—	PUNCT
ajtas-3259	36	15	ranging	range	VERB
ajtas-3259	36	16	from	from	ADP
ajtas-3259	36	17	rapid	rapid	ADJ
ajtas-3259	36	18	posttranslational	posttranslational	ADJ
ajtas-3259	36	19	regulation	regulation	NOUN
ajtas-3259	36	20	to	to	ADP
ajtas-3259	36	21	long	long	ADJ
ajtas-3259	36	22	-	-	PUNCT
ajtas-3259	36	23	term	term	NOUN
ajtas-3259	36	24	transcriptional	transcriptional	ADJ
ajtas-3259	36	25	remodeling	remodeling	NOUN
ajtas-3259	36	26	.	.	PUNCT
ajtas-3259	37	1	a	a	DET
ajtas-3259	37	2	clinical	clinical	ADJ
ajtas-3259	37	3	understanding	understanding	NOUN
ajtas-3259	37	4	of	of	ADP
ajtas-3259	37	5	these	these	DET
ajtas-3259	37	6	mechanisms	mechanism	NOUN
ajtas-3259	37	7	forms	form	VERB
ajtas-3259	37	8	the	the	DET
ajtas-3259	37	9	basis	basis	NOUN
ajtas-3259	37	10	for	for	ADP
ajtas-3259	37	11	the	the	DET
ajtas-3259	37	12	diagnosis	diagnosis	NOUN
ajtas-3259	37	13	and	and	CCONJ
ajtas-3259	37	14	treatment	treatment	NOUN
ajtas-3259	37	15	of	of	ADP
ajtas-3259	37	16	a	a	DET
ajtas-3259	37	17	wide	wide	ADJ
ajtas-3259	37	18	range	range	NOUN
ajtas-3259	37	19	of	of	ADP
ajtas-3259	37	20	endocrine	endocrine	NOUN
ajtas-3259	37	21	and	and	CCONJ
ajtas-3259	37	22	somatic	somatic	ADJ
ajtas-3259	37	23	disorders	disorder	NOUN
ajtas-3259	37	24	.	.	PUNCT
ajtas-3259	38	1	references	reference	NOUN
ajtas-3259	38	2	:	:	PUNCT
ajtas-3259	38	3	1.alberts	1.alberts	NUM
ajtas-3259	38	4	b.	b.	NOUN
ajtas-3259	38	5	,	,	PUNCT
ajtas-3259	38	6	et	et	PROPN
ajtas-3259	38	7	al	al	PROPN
ajtas-3259	38	8	.	.	PROPN
ajtas-3259	39	1	molecular	molecular	ADJ
ajtas-3259	39	2	biology	biology	NOUN
ajtas-3259	39	3	of	of	ADP
ajtas-3259	39	4	the	the	DET
ajtas-3259	39	5	cell	cell	NOUN
ajtas-3259	39	6	.	.	PUNCT
ajtas-3259	40	1	garland	garland	PROPN
ajtas-3259	40	2	science	science	PROPN
ajtas-3259	40	3	.	.	PUNCT
ajtas-3259	40	4	:	:	PUNCT
ajtas-3259	41	1	https://www.ncbi.nlm.nih.gov/books/nbk26830/	https://www.ncbi.nlm.nih.gov/books/nbk26830/	PROPN
ajtas-3259	41	2	2.hall	2.hall	NUM
ajtas-3259	41	3	j.e	j.e	PROPN
ajtas-3259	41	4	.	.	PROPN
ajtas-3259	41	5	,	,	PUNCT
ajtas-3259	41	6	guyton	guyton	PROPN
ajtas-3259	41	7	a.c	a.c	PROPN
ajtas-3259	41	8	.	.	PROPN
ajtas-3259	41	9	guyton	guyton	PROPN
ajtas-3259	41	10	and	and	CCONJ
ajtas-3259	41	11	hall	hall	PROPN
ajtas-3259	41	12	textbook	textbook	NOUN
ajtas-3259	41	13	of	of	ADP
ajtas-3259	41	14	medical	medical	ADJ
ajtas-3259	41	15	physiology	physiology	NOUN
ajtas-3259	41	16	.	.	PUNCT
ajtas-3259	42	1	elsevier	elsevier	NOUN
ajtas-3259	42	2	.	.	PUNCT
ajtas-3259	43	1	:	:	PUNCT
ajtas-3259	44	1	https://www.elsevier.com/books/guyton-and-hall-textbook-of-medical-physiology/9781455770052	https://www.elsevier.com/books/guyton-and-hall-textbook-of-medical-physiology/9781455770052	X
ajtas-3259	44	2	3.berg	3.berg	NUM
ajtas-3259	44	3	j.m	j.m	PROPN
ajtas-3259	44	4	.	.	PROPN
ajtas-3259	44	5	,	,	PUNCT
ajtas-3259	44	6	tymoczko	tymoczko	PROPN
ajtas-3259	44	7	j.l	j.l	PROPN
ajtas-3259	44	8	.	.	PROPN
ajtas-3259	44	9	,	,	PUNCT
ajtas-3259	44	10	stryer	stryer	PROPN
ajtas-3259	44	11	l.	l.	PROPN
ajtas-3259	44	12	biochemistry	biochemistry	PROPN
ajtas-3259	44	13	.	.	PUNCT
ajtas-3259	45	1	w.h	w.h	PROPN
ajtas-3259	45	2	.	.	PROPN
ajtas-3259	45	3	freeman	freeman	PROPN
ajtas-3259	45	4	.	.	PUNCT
ajtas-3259	46	1	https://www.ncbi.nlm.nih.gov/books/nbk22436/	https://www.ncbi.nlm.nih.gov/books/nbk22436/	PROPN
ajtas-3259	46	2	4.melmed	4.melmed	NUM
ajtas-3259	46	3	s.	s.	PROPN
ajtas-3259	46	4	,	,	PUNCT
ajtas-3259	46	5	polonsky	polonsky	PROPN
ajtas-3259	46	6	k.	k.	PROPN
ajtas-3259	46	7	,	,	PUNCT
ajtas-3259	46	8	larsen	larsen	PROPN
ajtas-3259	46	9	p.r	p.r	PROPN
ajtas-3259	46	10	.	.	PROPN
ajtas-3259	46	11	williams	williams	PROPN
ajtas-3259	46	12	textbook	textbook	NOUN
ajtas-3259	46	13	of	of	ADP
ajtas-3259	46	14	endocrinology	endocrinology	NOUN
ajtas-3259	46	15	.	.	PUNCT
ajtas-3259	47	1	elsevier.:https://www.elsevier.com	elsevier.:https://www.elsevier.com	X
ajtas-3259	47	2	/	/	SYM
ajtas-3259	47	3	books	books	PROPN
ajtas-3259	47	4	/	/	SYM
ajtas-3259	47	5	williams	williams	PROPN
ajtas-3259	47	6	-	-	PUNCT
ajtas-3259	47	7	textbook	textbook	NOUN
ajtas-3259	47	8	-	-	PUNCT
ajtas-3259	47	9	of	of	ADP
ajtas-3259	47	10	-	-	PUNCT
ajtas-3259	47	11	endocrinolo	endocrinolo	NOUN
ajtas-3259	47	12	-	-	PUNCT
ajtas-3259	47	13	gy/9780323555968	gy/9780323555968	PROPN
ajtas-3259	47	14	5.goodman	5.goodman	PROPN
ajtas-3259	47	15	&	&	CCONJ
ajtas-3259	47	16	gilman	gilman	PROPN
ajtas-3259	47	17	.	.	PUNCT
ajtas-3259	48	1	the	the	DET
ajtas-3259	48	2	pharmacological	pharmacological	ADJ
ajtas-3259	48	3	basis	basis	NOUN
ajtas-3259	48	4	of	of	ADP
ajtas-3259	48	5	therapeutics	therapeutic	NOUN
ajtas-3259	48	6	.	.	PUNCT
ajtas-3259	49	1	mcgraw	mcgraw	PROPN
ajtas-3259	49	2	-	-	PUNCT
ajtas-3259	49	3	hill	hill	NOUN
ajtas-3259	49	4	.	.	PUNCT
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ajtas-3259	50	2	6.endocrine	6.endocrine	NUM
ajtas-3259	50	3	society	society	NOUN
ajtas-3259	50	4	.	.	PUNCT
ajtas-3259	51	1	clinical	clinical	ADJ
ajtas-3259	51	2	practice	practice	NOUN
ajtas-3259	51	3	guidelines	guideline	NOUN
ajtas-3259	51	4	.	.	PUNCT
ajtas-3259	52	1	https://www.endocrine.org	https://www.endocrine.org	X
ajtas-3259	52	2	/clinical	/clinical	NOUN
ajtas-3259	52	3	-	-	PUNCT
ajtas-3259	52	4	practiceguidelines	practiceguideline	NOUN
ajtas-3259	52	5	u.s	u.s	PROPN
ajtas-3259	52	6	.	.	PROPN
ajtas-3259	52	7	national	national	PROPN
ajtas-3259	52	8	library	library	NOUN
ajtas-3259	52	9	of	of	ADP
ajtas-3259	52	10	medicine	medicine	NOUN
ajtas-3259	52	11	(	(	PUNCT
ajtas-3259	52	12	nlm	nlm	PROPN
ajtas-3259	52	13	)	)	PUNCT
ajtas-3259	52	14	.	.	PUNCT
ajtas-3259	53	1	overview	overview	NOUN
ajtas-3259	53	2	of	of	ADP
ajtas-3259	53	3	hormones	hormone	NOUN
ajtas-3259	53	4	and	and	CCONJ
ajtas-3259	53	5	hormone	hormone	NOUN
ajtas-3259	53	6	receptors	receptor	NOUN
ajtas-3259	53	7	.	.	PUNCT
ajtas-3259	54	1	https://www.ncbi.nlm.nih.gov/books/nbk279396/	https://www.ncbi.nlm.nih.gov/books/nbk279396/	PROPN
ajtas-3259	54	2	7.american	7.american	NUM
ajtas-3259	54	3	physiological	physiological	ADJ
ajtas-3259	54	4	society	society	NOUN
ajtas-3259	54	5	.	.	PUNCT
ajtas-3259	55	1	review	review	NOUN
ajtas-3259	55	2	of	of	ADP
ajtas-3259	55	3	hormonal	hormonal	ADJ
ajtas-3259	55	4	signaling	signaling	NOUN
ajtas-3259	55	5	.	.	PUNCT
ajtas-3259	56	1	https://journals.physiology.org/	https://journals.physiology.org/	PROPN
ajtas-3259	56	2	https://www.endocrine.org/	https://www.endocrine.org/	NOUN
ajtas-3259	56	3	american	american	PROPN
ajtas-3259	56	4	journal	journal	PROPN
ajtas-3259	56	5	of	of	ADP
ajtas-3259	56	6	technology	technology	NOUN
ajtas-3259	56	7	and	and	CCONJ
ajtas-3259	56	8	applied	apply	VERB
ajtas-3259	56	9	sciences	science	NOUN
ajtas-3259	56	10	43	43	NUM
ajtas-3259	56	11	,	,	PUNCT
ajtas-3259	56	12	december	december	PROPN
ajtas-3259	56	13	2025	2025	NUM
ajtas-3259	56	14	p	p	NOUN
ajtas-3259	56	15	a	a	DET
ajtas-3259	56	16	g	g	NOUN
ajtas-3259	56	17	e	e	NOUN
ajtas-3259	56	18	|	|	ADV
ajtas-3259	56	19	60	60	NUM
ajtas-3259	56	20	www.americanjournal.org	www.americanjournal.org	PROPN
ajtas-3259	56	21	8.national	8.national	PROPN
ajtas-3259	56	22	institute	institute	NOUN
ajtas-3259	56	23	of	of	ADP
ajtas-3259	56	24	diabetes	diabetes	NOUN
ajtas-3259	56	25	and	and	CCONJ
ajtas-3259	56	26	digestive	digestive	ADJ
ajtas-3259	56	27	and	and	CCONJ
ajtas-3259	56	28	kidney	kidney	NOUN
ajtas-3259	56	29	diseases	disease	NOUN
ajtas-3259	56	30	(	(	PUNCT
ajtas-3259	56	31	niddk	niddk	NOUN
ajtas-3259	56	32	)	)	PUNCT
ajtas-3259	56	33	.	.	PUNCT
ajtas-3259	57	1	hormonal	hormonal	ADJ
ajtas-3259	57	2	disorders	disorder	NOUN
ajtas-3259	57	3	.	.	PUNCT
ajtas-3259	58	1	https://www.niddk.nih.gov/	https://www.niddk.nih.gov/	PROPN
ajtas-3259	58	2	9.u.s	9.u.s	NUM
ajtas-3259	58	3	.	.	PUNCT
ajtas-3259	58	4	national	national	PROPN
ajtas-3259	58	5	library	library	NOUN
ajtas-3259	58	6	of	of	ADP
ajtas-3259	58	7	medicine	medicine	NOUN
ajtas-3259	58	8	(	(	PUNCT
ajtas-3259	58	9	pubmed	pubmed	PROPN
ajtas-3259	58	10	)	)	PUNCT
ajtas-3259	58	11	.	.	PUNCT
ajtas-3259	59	1	articles	article	NOUN
ajtas-3259	59	2	on	on	ADP
ajtas-3259	59	3	hormone	hormone	NOUN
ajtas-3259	59	4	receptors	receptor	NOUN
ajtas-3259	59	5	.	.	PUNCT
ajtas-3259	60	1	https://pubmed.ncbi.nlm.nih.gov/	https://pubmed.ncbi.nlm.nih.gov/	NOUN