id sid tid token lemma pos american_scientific_journal-3226 1 1 8 8 NUM american_scientific_journal-3226 1 2 american american ADJ american_scientific_journal-3226 1 3 scientific scientific ADJ american_scientific_journal-3226 1 4 research research NOUN american_scientific_journal-3226 1 5 journal journal NOUN american_scientific_journal-3226 1 6 for for ADP american_scientific_journal-3226 1 7 engineering engineering NOUN american_scientific_journal-3226 1 8 , , PUNCT american_scientific_journal-3226 1 9 technology technology NOUN american_scientific_journal-3226 1 10 , , PUNCT american_scientific_journal-3226 1 11 and and CCONJ american_scientific_journal-3226 1 12 sciences science NOUN american_scientific_journal-3226 1 13 ( ( PUNCT american_scientific_journal-3226 1 14 asrjets asrjet NOUN american_scientific_journal-3226 1 15 ) ) PUNCT american_scientific_journal-3226 1 16 issn issn PROPN american_scientific_journal-3226 1 17 ( ( PUNCT american_scientific_journal-3226 1 18 print print NOUN american_scientific_journal-3226 1 19 ) ) PUNCT american_scientific_journal-3226 1 20 2313 2313 NUM american_scientific_journal-3226 1 21 - - SYM american_scientific_journal-3226 1 22 4410 4410 NUM american_scientific_journal-3226 1 23 , , PUNCT american_scientific_journal-3226 1 24 issn issn PROPN american_scientific_journal-3226 1 25 ( ( PUNCT american_scientific_journal-3226 1 26 online online ADJ american_scientific_journal-3226 1 27 ) ) PUNCT american_scientific_journal-3226 1 28 2313 2313 NUM american_scientific_journal-3226 1 29 - - SYM american_scientific_journal-3226 1 30 4402 4402 NUM american_scientific_journal-3226 1 31 © © PROPN american_scientific_journal-3226 1 32 global global ADJ american_scientific_journal-3226 1 33 society society NOUN american_scientific_journal-3226 1 34 of of ADP american_scientific_journal-3226 1 35 scientific scientific ADJ american_scientific_journal-3226 1 36 research research NOUN american_scientific_journal-3226 1 37 and and CCONJ american_scientific_journal-3226 1 38 researchers researcher NOUN american_scientific_journal-3226 1 39 http://asrjetsjournal.org/ http://asrjetsjournal.org/ NOUN american_scientific_journal-3226 1 40 gene gene NOUN american_scientific_journal-3226 1 41 expression expression NOUN american_scientific_journal-3226 1 42 of of ADP american_scientific_journal-3226 1 43 p53 p53 NOUN american_scientific_journal-3226 1 44 and and CCONJ american_scientific_journal-3226 1 45 bcl-2 bcl-2 PRON american_scientific_journal-3226 1 46 as as ADP american_scientific_journal-3226 1 47 markers marker NOUN american_scientific_journal-3226 1 48 of of ADP american_scientific_journal-3226 1 49 prostate prostate NOUN american_scientific_journal-3226 1 50 cancer cancer NOUN american_scientific_journal-3226 1 51 progression progression NOUN american_scientific_journal-3226 1 52 bungaran bungaran NOUN american_scientific_journal-3226 1 53 sihombinga sihombinga PRON american_scientific_journal-3226 1 54 * * SYM american_scientific_journal-3226 1 55 , , PUNCT american_scientific_journal-3226 1 56 sumaryati sumaryati PROPN american_scientific_journal-3226 1 57 syukurb syukurb PROPN american_scientific_journal-3226 1 58 , , PUNCT american_scientific_journal-3226 1 59 sanusi sanusi PROPN american_scientific_journal-3226 1 60 ibrahimc ibrahimc PROPN american_scientific_journal-3226 1 61 , , PUNCT american_scientific_journal-3226 1 62 djong djong PROPN american_scientific_journal-3226 1 63 hon hon PROPN american_scientific_journal-3226 1 64 congd congd PROPN american_scientific_journal-3226 1 65 , , PUNCT american_scientific_journal-3226 1 66 didik didik ADJ american_scientific_journal-3226 1 67 setyoheryantoe setyoheryantoe NOUN american_scientific_journal-3226 1 68 adivision adivision NOUN american_scientific_journal-3226 1 69 of of ADP american_scientific_journal-3226 1 70 urology urology NOUN american_scientific_journal-3226 1 71 , , PUNCT american_scientific_journal-3226 1 72 faculty faculty NOUN american_scientific_journal-3226 1 73 of of ADP american_scientific_journal-3226 1 74 medicine medicine NOUN american_scientific_journal-3226 1 75 , , PUNCT american_scientific_journal-3226 1 76 prima prima PROPN american_scientific_journal-3226 1 77 university university PROPN american_scientific_journal-3226 1 78 medan medan PROPN american_scientific_journal-3226 1 79 , , PUNCT american_scientific_journal-3226 1 80 indonesia indonesia PROPN american_scientific_journal-3226 1 81 
 
 SPACE american_scientific_journal-3226 1 82 bdepartment bdepartment NOUN american_scientific_journal-3226 1 83 of of ADP american_scientific_journal-3226 1 84 chemistry chemistry NOUN american_scientific_journal-3226 1 85 , , PUNCT american_scientific_journal-3226 1 86 faculty faculty NOUN american_scientific_journal-3226 1 87 of of ADP american_scientific_journal-3226 1 88 mathematics mathematic NOUN american_scientific_journal-3226 1 89 and and CCONJ american_scientific_journal-3226 1 90 natural natural ADJ american_scientific_journal-3226 1 91 sciences science NOUN american_scientific_journal-3226 1 92 , , PUNCT american_scientific_journal-3226 1 93 andalas andalas PROPN american_scientific_journal-3226 1 94 university university PROPN american_scientific_journal-3226 1 95 , , PUNCT american_scientific_journal-3226 1 96 padang padang PROPN american_scientific_journal-3226 1 97 , , PUNCT american_scientific_journal-3226 1 98 indonesia indonesia PROPN american_scientific_journal-3226 1 99 cdepartment cdepartment NOUN american_scientific_journal-3226 1 100 of of ADP american_scientific_journal-3226 1 101 chemistry chemistry NOUN american_scientific_journal-3226 1 102 , , PUNCT american_scientific_journal-3226 1 103 faculty faculty NOUN american_scientific_journal-3226 1 104 of of ADP american_scientific_journal-3226 1 105 mathematics mathematic NOUN american_scientific_journal-3226 1 106 and and CCONJ american_scientific_journal-3226 1 107 natural natural ADJ american_scientific_journal-3226 1 108 sciences science NOUN american_scientific_journal-3226 1 109 , , PUNCT american_scientific_journal-3226 1 110 andalas andalas PROPN american_scientific_journal-3226 1 111 university university PROPN american_scientific_journal-3226 1 112 , , PUNCT american_scientific_journal-3226 1 113 padang padang PROPN american_scientific_journal-3226 1 114 , , PUNCT american_scientific_journal-3226 1 115 indonesia indonesia PROPN american_scientific_journal-3226 1 116 ddepartment ddepartment NOUN american_scientific_journal-3226 1 117 of of ADP american_scientific_journal-3226 1 118 biology biology NOUN american_scientific_journal-3226 1 119 , , PUNCT american_scientific_journal-3226 1 120 faculty faculty NOUN american_scientific_journal-3226 1 121 of of ADP american_scientific_journal-3226 1 122 mathematics mathematic NOUN american_scientific_journal-3226 1 123 and and CCONJ american_scientific_journal-3226 1 124 natural natural ADJ american_scientific_journal-3226 1 125 sciences science NOUN american_scientific_journal-3226 1 126 , , PUNCT american_scientific_journal-3226 1 127 andalas andalas PROPN american_scientific_journal-3226 1 128 university university PROPN american_scientific_journal-3226 1 129 , , PUNCT american_scientific_journal-3226 1 130 padang padang PROPN american_scientific_journal-3226 1 131 , , PUNCT american_scientific_journal-3226 1 132 indonesia indonesia PROPN american_scientific_journal-3226 1 133 edivision edivision NOUN american_scientific_journal-3226 1 134 of of ADP american_scientific_journal-3226 1 135 pathology pathology NOUN american_scientific_journal-3226 1 136 anatomy anatomy PROPN american_scientific_journal-3226 1 137 gajah gajah PROPN american_scientific_journal-3226 1 138 mada mada PROPN american_scientific_journal-3226 1 139 university university PROPN american_scientific_journal-3226 1 140 yogyakarta yogyakarta PROPN american_scientific_journal-3226 1 141 , , PUNCT american_scientific_journal-3226 1 142 indonesia indonesia PROPN american_scientific_journal-3226 1 143 abstract abstract ADJ american_scientific_journal-3226 1 144 introduction introduction NOUN american_scientific_journal-3226 1 145 : : PUNCT american_scientific_journal-3226 1 146 apoptotic apoptotic ADJ american_scientific_journal-3226 1 147 genes gene NOUN american_scientific_journal-3226 1 148 regulate regulate VERB american_scientific_journal-3226 1 149 apoptosis apoptosis NOUN american_scientific_journal-3226 1 150 by by ADP american_scientific_journal-3226 1 151 the the DET american_scientific_journal-3226 1 152 action action NOUN american_scientific_journal-3226 1 153 of of ADP american_scientific_journal-3226 1 154 their their PRON american_scientific_journal-3226 1 155 proand proand NOUN american_scientific_journal-3226 1 156 antiapoptotic antiapoptotic ADJ american_scientific_journal-3226 1 157 products product NOUN american_scientific_journal-3226 1 158 . . PUNCT american_scientific_journal-3226 2 1 among among ADP american_scientific_journal-3226 2 2 the the DET american_scientific_journal-3226 2 3 most most ADV american_scientific_journal-3226 2 4 important important ADJ american_scientific_journal-3226 2 5 proteins protein NOUN american_scientific_journal-3226 2 6 are be AUX american_scientific_journal-3226 2 7 p53 p53 NOUN american_scientific_journal-3226 2 8 and and CCONJ american_scientific_journal-3226 2 9 bcl-2 bcl-2 NOUN american_scientific_journal-3226 2 10 proteins protein NOUN american_scientific_journal-3226 2 11 . . PUNCT american_scientific_journal-3226 3 1 the the DET american_scientific_journal-3226 3 2 rate rate NOUN american_scientific_journal-3226 3 3 of of ADP american_scientific_journal-3226 3 4 tumor tumor NOUN american_scientific_journal-3226 3 5 growth growth NOUN american_scientific_journal-3226 3 6 is be AUX american_scientific_journal-3226 3 7 dependent dependent ADJ american_scientific_journal-3226 3 8 on on ADP american_scientific_journal-3226 3 9 the the DET american_scientific_journal-3226 3 10 balance balance NOUN american_scientific_journal-3226 3 11 between between ADP american_scientific_journal-3226 3 12 proliferation proliferation NOUN american_scientific_journal-3226 3 13 and and CCONJ american_scientific_journal-3226 3 14 apoptosis apoptosis NOUN american_scientific_journal-3226 3 15 at at ADP american_scientific_journal-3226 3 16 all all DET american_scientific_journal-3226 3 17 stages stage NOUN american_scientific_journal-3226 3 18 of of ADP american_scientific_journal-3226 3 19 carcinogenesis carcinogenesis NOUN american_scientific_journal-3226 3 20 . . PUNCT american_scientific_journal-3226 4 1 the the DET american_scientific_journal-3226 4 2 differential differential ADJ american_scientific_journal-3226 4 3 expression expression NOUN american_scientific_journal-3226 4 4 of of ADP american_scientific_journal-3226 4 5 these these DET american_scientific_journal-3226 4 6 apoptotic apoptotic ADJ american_scientific_journal-3226 4 7 genes gene NOUN american_scientific_journal-3226 4 8 was be AUX american_scientific_journal-3226 4 9 analyzed analyze VERB american_scientific_journal-3226 4 10 in in ADP american_scientific_journal-3226 4 11 relation relation NOUN american_scientific_journal-3226 4 12 to to ADP american_scientific_journal-3226 4 13 clinicopathological clinicopathological ADJ american_scientific_journal-3226 4 14 criteria criterion NOUN american_scientific_journal-3226 4 15 as as ADP american_scientific_journal-3226 4 16 gleason gleason PROPN american_scientific_journal-3226 4 17 score score NOUN american_scientific_journal-3226 4 18 in in ADP american_scientific_journal-3226 4 19 man man NOUN american_scientific_journal-3226 4 20 with with ADP american_scientific_journal-3226 4 21 prostate prostate NOUN american_scientific_journal-3226 4 22 cancer cancer NOUN american_scientific_journal-3226 4 23 . . PUNCT american_scientific_journal-3226 5 1 every every DET american_scientific_journal-3226 5 2 prostate prostate NOUN american_scientific_journal-3226 5 3 cancer cancer NOUN american_scientific_journal-3226 5 4 patient patient NOUN american_scientific_journal-3226 5 5 who who PRON american_scientific_journal-3226 5 6 underwent undergo VERB american_scientific_journal-3226 5 7 histopathology histopathology NOUN american_scientific_journal-3226 5 8 examination examination NOUN american_scientific_journal-3226 5 9 which which PRON american_scientific_journal-3226 5 10 fulfill fulfill VERB american_scientific_journal-3226 5 11 the the DET american_scientific_journal-3226 5 12 criteria criterion NOUN american_scientific_journal-3226 5 13 were be AUX american_scientific_journal-3226 5 14 included include VERB american_scientific_journal-3226 5 15 in in ADP american_scientific_journal-3226 5 16 the the DET american_scientific_journal-3226 5 17 study study NOUN american_scientific_journal-3226 5 18 . . PUNCT american_scientific_journal-3226 6 1 samples sample NOUN american_scientific_journal-3226 6 2 then then ADV american_scientific_journal-3226 6 3 rearrange rearrange VERB american_scientific_journal-3226 6 4 into into ADP american_scientific_journal-3226 6 5 low low ADJ american_scientific_journal-3226 6 6 gleason gleason PROPN american_scientific_journal-3226 6 7 score score NOUN american_scientific_journal-3226 6 8 ( ( PUNCT american_scientific_journal-3226 6 9 2 2 NUM american_scientific_journal-3226 6 10 - - SYM american_scientific_journal-3226 6 11 6 6 NUM american_scientific_journal-3226 6 12 ) ) PUNCT american_scientific_journal-3226 6 13 and and CCONJ american_scientific_journal-3226 6 14 high high ADJ american_scientific_journal-3226 6 15 gleason gleason PROPN american_scientific_journal-3226 6 16 score score NOUN american_scientific_journal-3226 6 17 ( ( PUNCT american_scientific_journal-3226 6 18 7 7 NUM american_scientific_journal-3226 6 19 - - SYM american_scientific_journal-3226 6 20 10 10 NUM american_scientific_journal-3226 6 21 ) ) PUNCT american_scientific_journal-3226 6 22 . . PUNCT american_scientific_journal-3226 7 1 all all DET american_scientific_journal-3226 7 2 samples sample NOUN american_scientific_journal-3226 7 3 then then ADV american_scientific_journal-3226 7 4 underwent undergo VERB american_scientific_journal-3226 7 5 gene gene NOUN american_scientific_journal-3226 7 6 expression expression NOUN american_scientific_journal-3226 7 7 assay assay VERB american_scientific_journal-3226 7 8 for for ADP american_scientific_journal-3226 7 9 p53 p53 NOUN american_scientific_journal-3226 7 10 and and CCONJ american_scientific_journal-3226 7 11 bcl-2 bcl-2 PRON american_scientific_journal-3226 7 12 to to PART american_scientific_journal-3226 7 13 be be AUX american_scientific_journal-3226 7 14 analyzed analyze VERB american_scientific_journal-3226 7 15 for for ADP american_scientific_journal-3226 7 16 each each DET american_scientific_journal-3226 7 17 ’s ’s PART american_scientific_journal-3226 7 18 relationship relationship NOUN american_scientific_journal-3226 7 19 with with ADP american_scientific_journal-3226 7 20 each each DET american_scientific_journal-3226 7 21 group group NOUN american_scientific_journal-3226 7 22 . . PUNCT american_scientific_journal-3226 8 1 the the DET american_scientific_journal-3226 8 2 aim aim NOUN american_scientific_journal-3226 8 3 of of ADP american_scientific_journal-3226 8 4 this this DET american_scientific_journal-3226 8 5 study study NOUN american_scientific_journal-3226 8 6 was be AUX american_scientific_journal-3226 8 7 to to PART american_scientific_journal-3226 8 8 evaluate evaluate VERB american_scientific_journal-3226 8 9 tumor tumor NOUN american_scientific_journal-3226 8 10 proliferation proliferation NOUN american_scientific_journal-3226 8 11 and and CCONJ american_scientific_journal-3226 8 12 the the DET american_scientific_journal-3226 8 13 expression expression NOUN american_scientific_journal-3226 8 14 of of ADP american_scientific_journal-3226 8 15 the the DET american_scientific_journal-3226 8 16 proto proto NOUN american_scientific_journal-3226 8 17 - - PUNCT american_scientific_journal-3226 8 18 oncogene oncogene ADJ american_scientific_journal-3226 8 19 bcl-2 bcl-2 ADJ american_scientific_journal-3226 8 20 and and CCONJ american_scientific_journal-3226 8 21 tumor tumor NOUN american_scientific_journal-3226 8 22 suppressor suppressor NOUN american_scientific_journal-3226 8 23 gene gene NOUN american_scientific_journal-3226 8 24 p53 p53 NOUN american_scientific_journal-3226 8 25 in in ADP american_scientific_journal-3226 8 26 patients patient NOUN american_scientific_journal-3226 8 27 undergoing undergo VERB american_scientific_journal-3226 8 28 transurethral transurethral ADJ american_scientific_journal-3226 8 29 prostatectomy prostatectomy NOUN american_scientific_journal-3226 8 30 for for ADP american_scientific_journal-3226 8 31 prostate prostate NOUN american_scientific_journal-3226 8 32 cancer cancer NOUN american_scientific_journal-3226 8 33 , , PUNCT american_scientific_journal-3226 8 34 and and CCONJ american_scientific_journal-3226 8 35 to to PART american_scientific_journal-3226 8 36 define define VERB american_scientific_journal-3226 8 37 their their PRON american_scientific_journal-3226 8 38 prognostic prognostic ADJ american_scientific_journal-3226 8 39 roles role NOUN american_scientific_journal-3226 8 40 through through ADP american_scientific_journal-3226 8 41 correlation correlation NOUN american_scientific_journal-3226 8 42 with with ADP american_scientific_journal-3226 8 43 final final ADJ american_scientific_journal-3226 8 44 gleason gleason PROPN american_scientific_journal-3226 8 45 score score NOUN american_scientific_journal-3226 8 46 , , PUNCT american_scientific_journal-3226 8 47 using use VERB american_scientific_journal-3226 8 48 qrtpcr qrtpcr ADJ american_scientific_journal-3226 8 49 .. .. PUNCT american_scientific_journal-3226 8 50 a a DET american_scientific_journal-3226 8 51 total total NOUN american_scientific_journal-3226 8 52 of of ADP american_scientific_journal-3226 8 53 40 40 NUM american_scientific_journal-3226 8 54 samples sample NOUN american_scientific_journal-3226 8 55 consisting consist VERB american_scientific_journal-3226 8 56 of of ADP american_scientific_journal-3226 8 57 28 28 NUM american_scientific_journal-3226 8 58 gs gs NOUN american_scientific_journal-3226 8 59 ( ( PUNCT american_scientific_journal-3226 8 60 2 2 NUM american_scientific_journal-3226 8 61 - - SYM american_scientific_journal-3226 8 62 6 6 NUM american_scientific_journal-3226 8 63 ) ) PUNCT american_scientific_journal-3226 8 64 and and CCONJ american_scientific_journal-3226 8 65 12 12 NUM american_scientific_journal-3226 8 66 gs gs NOUN american_scientific_journal-3226 8 67 ( ( PUNCT american_scientific_journal-3226 8 68 7 7 NUM american_scientific_journal-3226 8 69 - - SYM american_scientific_journal-3226 8 70 10 10 NUM american_scientific_journal-3226 8 71 ) ) PUNCT american_scientific_journal-3226 8 72 samples sample NOUN american_scientific_journal-3226 8 73 were be AUX american_scientific_journal-3226 8 74 included include VERB american_scientific_journal-3226 8 75 in in ADP american_scientific_journal-3226 8 76 the the DET american_scientific_journal-3226 8 77 study study NOUN american_scientific_journal-3226 8 78 . . PUNCT american_scientific_journal-3226 9 1 there there PRON american_scientific_journal-3226 9 2 was be VERB american_scientific_journal-3226 9 3 a a DET american_scientific_journal-3226 9 4 significant significant ADJ american_scientific_journal-3226 9 5 mean mean ADJ american_scientific_journal-3226 9 6 difference difference NOUN american_scientific_journal-3226 9 7 between between ADP american_scientific_journal-3226 9 8 p53 p53 NOUN american_scientific_journal-3226 9 9 mrna mrna NOUN american_scientific_journal-3226 9 10 in in ADP american_scientific_journal-3226 9 11 the the DET american_scientific_journal-3226 9 12 gs gs PROPN american_scientific_journal-3226 9 13 2 2 NUM american_scientific_journal-3226 9 14 - - SYM american_scientific_journal-3226 9 15 6 6 NUM american_scientific_journal-3226 9 16 and and CCONJ american_scientific_journal-3226 9 17 7 7 NUM american_scientific_journal-3226 9 18 - - SYM american_scientific_journal-3226 9 19 10 10 NUM american_scientific_journal-3226 9 20 groups group NOUN american_scientific_journal-3226 9 21 ( ( PUNCT american_scientific_journal-3226 9 22 p p X american_scientific_journal-3226 9 23 < < X american_scientific_journal-3226 9 24 0.001 0.001 NUM american_scientific_journal-3226 9 25 ) ) PUNCT american_scientific_journal-3226 9 26 , , PUNCT american_scientific_journal-3226 9 27 but but CCONJ american_scientific_journal-3226 9 28 not not PART american_scientific_journal-3226 9 29 for for ADP american_scientific_journal-3226 9 30 bcl-2 bcl-2 VERB american_scientific_journal-3226 9 31 mrna mrna PROPN american_scientific_journal-3226 9 32 . . PUNCT american_scientific_journal-3226 10 1 based base VERB american_scientific_journal-3226 10 2 on on ADP american_scientific_journal-3226 10 3 a a DET american_scientific_journal-3226 10 4 multivariate multivariate NOUN american_scientific_journal-3226 10 5 analysis analysis NOUN american_scientific_journal-3226 10 6 , , PUNCT american_scientific_journal-3226 10 7 only only ADV american_scientific_journal-3226 10 8 p53 p53 PROPN american_scientific_journal-3226 10 9 mrna mrna PROPN american_scientific_journal-3226 10 10 had have VERB american_scientific_journal-3226 10 11 a a DET american_scientific_journal-3226 10 12 significant significant ADJ american_scientific_journal-3226 10 13 association association NOUN american_scientific_journal-3226 10 14 with with ADP american_scientific_journal-3226 10 15 the the DET american_scientific_journal-3226 10 16 gs gs PROPN american_scientific_journal-3226 10 17 group group NOUN american_scientific_journal-3226 10 18 in in ADP american_scientific_journal-3226 10 19 adenocarcinoma adenocarcinoma NOUN american_scientific_journal-3226 10 20 prostate prostate NOUN american_scientific_journal-3226 10 21 with with ADP american_scientific_journal-3226 10 22 p p NOUN american_scientific_journal-3226 10 23 = = PROPN american_scientific_journal-3226 10 24 0.014 0.014 NUM american_scientific_journal-3226 10 25 , , PUNCT american_scientific_journal-3226 10 26 95 95 NUM american_scientific_journal-3226 10 27 % % NOUN american_scientific_journal-3226 10 28 ci ci NOUN american_scientific_journal-3226 10 29 0.926 0.926 NUM american_scientific_journal-3226 10 30 - - SYM american_scientific_journal-3226 10 31 0.991 0.991 NUM american_scientific_journal-3226 10 32 with with ADP american_scientific_journal-3226 10 33 a a DET american_scientific_journal-3226 10 34 predicted predict VERB american_scientific_journal-3226 10 35 value value NOUN american_scientific_journal-3226 10 36 of of ADP american_scientific_journal-3226 10 37 77.5 77.5 NUM american_scientific_journal-3226 10 38 % % NOUN american_scientific_journal-3226 10 39 . . PUNCT american_scientific_journal-3226 11 1 we we PRON american_scientific_journal-3226 11 2 conclude conclude VERB american_scientific_journal-3226 11 3 that that PRON american_scientific_journal-3226 11 4 p53 p53 NOUN american_scientific_journal-3226 11 5 mrna mrna PROPN american_scientific_journal-3226 11 6 is be AUX american_scientific_journal-3226 11 7 an an DET american_scientific_journal-3226 11 8 independent independent ADJ american_scientific_journal-3226 11 9 predictive predictive ADJ american_scientific_journal-3226 11 10 factor factor NOUN american_scientific_journal-3226 11 11 of of ADP american_scientific_journal-3226 11 12 gleason gleason PROPN american_scientific_journal-3226 11 13 score score NOUN american_scientific_journal-3226 11 14 - - PUNCT american_scientific_journal-3226 11 15 based base VERB american_scientific_journal-3226 11 16 progression progression NOUN american_scientific_journal-3226 11 17 of of ADP american_scientific_journal-3226 11 18 adenocarcinoma adenocarcinoma NOUN american_scientific_journal-3226 11 19 prostate prostate NOUN american_scientific_journal-3226 11 20 . . PUNCT american_scientific_journal-3226 12 1 keywords keyword NOUN american_scientific_journal-3226 12 2 : : PUNCT american_scientific_journal-3226 12 3 prostate prostate NOUN american_scientific_journal-3226 12 4 cancer cancer NOUN american_scientific_journal-3226 12 5 ; ; PUNCT american_scientific_journal-3226 12 6 p53 p53 NOUN american_scientific_journal-3226 12 7 ; ; PUNCT american_scientific_journal-3226 12 8 bcl-2 bcl-2 NUM american_scientific_journal-3226 12 9 ; ; PUNCT american_scientific_journal-3226 12 10 gene gene NOUN american_scientific_journal-3226 12 11 expression expression NOUN american_scientific_journal-3226 12 12 ; ; PUNCT american_scientific_journal-3226 12 13 gleason gleason PROPN american_scientific_journal-3226 12 14 score score PROPN american_scientific_journal-3226 12 15 . . PUNCT american_scientific_journal-3226 13 1 ----------------------------------------------------------------------- ----------------------------------------------------------------------- PUNCT american_scientific_journal-3226 14 1 * * PUNCT american_scientific_journal-3226 14 2 corresponding correspond VERB american_scientific_journal-3226 14 3 author author NOUN american_scientific_journal-3226 14 4 . . PUNCT american_scientific_journal-3226 15 1 http://asrjetsjournal.org/ http://asrjetsjournal.org/ PROPN american_scientific_journal-3226 15 2 american american PROPN american_scientific_journal-3226 15 3 scientific scientific PROPN american_scientific_journal-3226 15 4 research research NOUN american_scientific_journal-3226 15 5 journal journal NOUN american_scientific_journal-3226 15 6 for for ADP american_scientific_journal-3226 15 7 engineering engineering NOUN american_scientific_journal-3226 15 8 , , PUNCT american_scientific_journal-3226 15 9 technology technology NOUN american_scientific_journal-3226 15 10 , , PUNCT american_scientific_journal-3226 15 11 and and CCONJ american_scientific_journal-3226 15 12 sciences science NOUN american_scientific_journal-3226 15 13 ( ( PUNCT american_scientific_journal-3226 15 14 asrjets asrjet NOUN american_scientific_journal-3226 15 15 ) ) PUNCT american_scientific_journal-3226 15 16 ( ( PUNCT american_scientific_journal-3226 15 17 2017 2017 NUM american_scientific_journal-3226 15 18 ) ) PUNCT american_scientific_journal-3226 15 19 volume volume NOUN american_scientific_journal-3226 15 20 35 35 NUM american_scientific_journal-3226 15 21 , , PUNCT american_scientific_journal-3226 15 22 no no DET american_scientific_journal-3226 15 23 1 1 NUM american_scientific_journal-3226 15 24 , , PUNCT american_scientific_journal-3226 15 25 pp pp ADV american_scientific_journal-3226 15 26 8 8 NUM american_scientific_journal-3226 15 27 - - SYM american_scientific_journal-3226 15 28 14 14 NUM american_scientific_journal-3226 15 29 9 9 NUM american_scientific_journal-3226 15 30 1 1 NUM american_scientific_journal-3226 15 31 . . PUNCT american_scientific_journal-3226 16 1 introduction introduction NOUN american_scientific_journal-3226 16 2 mutated mutate VERB american_scientific_journal-3226 16 3 p53 p53 NOUN american_scientific_journal-3226 16 4 is be AUX american_scientific_journal-3226 16 5 one one NUM american_scientific_journal-3226 16 6 of of ADP american_scientific_journal-3226 16 7 the the DET american_scientific_journal-3226 16 8 most most ADV american_scientific_journal-3226 16 9 common common ADJ american_scientific_journal-3226 16 10 genetic genetic ADJ american_scientific_journal-3226 16 11 abnormalities abnormality NOUN american_scientific_journal-3226 16 12 detected detect VERB american_scientific_journal-3226 16 13 in in ADP american_scientific_journal-3226 16 14 human human ADJ american_scientific_journal-3226 16 15 cancers cancer NOUN american_scientific_journal-3226 16 16 . . PUNCT american_scientific_journal-3226 17 1 as as ADP american_scientific_journal-3226 17 2 a a DET american_scientific_journal-3226 17 3 major major ADJ american_scientific_journal-3226 17 4 tumor tumor NOUN american_scientific_journal-3226 17 5 suppressor suppressor NOUN american_scientific_journal-3226 17 6 gene gene NOUN american_scientific_journal-3226 17 7 , , PUNCT american_scientific_journal-3226 17 8 p53 p53 NOUN american_scientific_journal-3226 17 9 regulates regulate VERB american_scientific_journal-3226 17 10 the the DET american_scientific_journal-3226 17 11 cell cell NOUN american_scientific_journal-3226 17 12 cycle cycle NOUN american_scientific_journal-3226 17 13 , , PUNCT american_scientific_journal-3226 17 14 controls control VERB american_scientific_journal-3226 17 15 dna dna NOUN american_scientific_journal-3226 17 16 repair repair NOUN american_scientific_journal-3226 17 17 mechanisms mechanism NOUN american_scientific_journal-3226 17 18 and and CCONJ american_scientific_journal-3226 17 19 activates activate VERB american_scientific_journal-3226 17 20 apoptotic apoptotic ADJ american_scientific_journal-3226 17 21 pathways pathway NOUN american_scientific_journal-3226 18 1 [ [ X american_scientific_journal-3226 18 2 1 1 NUM american_scientific_journal-3226 18 3 ] ] PUNCT american_scientific_journal-3226 18 4 . . PUNCT american_scientific_journal-3226 19 1 the the DET american_scientific_journal-3226 19 2 clinical clinical ADJ american_scientific_journal-3226 19 3 correlates correlate NOUN american_scientific_journal-3226 19 4 of of ADP american_scientific_journal-3226 19 5 p53 p53 NOUN american_scientific_journal-3226 19 6 mutations mutation NOUN american_scientific_journal-3226 19 7 malignancies malignancy NOUN american_scientific_journal-3226 19 8 have have AUX american_scientific_journal-3226 19 9 not not PART american_scientific_journal-3226 19 10 been be AUX american_scientific_journal-3226 19 11 fully fully ADV american_scientific_journal-3226 19 12 delineated delineated ADJ american_scientific_journal-3226 19 13 but but CCONJ american_scientific_journal-3226 19 14 have have AUX american_scientific_journal-3226 19 15 shown show VERB american_scientific_journal-3226 19 16 that that SCONJ american_scientific_journal-3226 19 17 p53 p53 NOUN american_scientific_journal-3226 19 18 mutation mutation NOUN american_scientific_journal-3226 19 19 accelerates accelerate VERB american_scientific_journal-3226 19 20 cancer cancer NOUN american_scientific_journal-3226 19 21 progression progression NOUN american_scientific_journal-3226 19 22 and and CCONJ american_scientific_journal-3226 19 23 increases increase VERB american_scientific_journal-3226 19 24 tumor tumor NOUN american_scientific_journal-3226 19 25 invasiveness invasiveness NOUN american_scientific_journal-3226 19 26 and and CCONJ american_scientific_journal-3226 19 27 metastasis metastasis NOUN american_scientific_journal-3226 19 28 , , PUNCT american_scientific_journal-3226 19 29 which which PRON american_scientific_journal-3226 19 30 is be AUX american_scientific_journal-3226 19 31 not not PART american_scientific_journal-3226 19 32 , , PUNCT american_scientific_journal-3226 19 33 however however ADV american_scientific_journal-3226 19 34 , , PUNCT american_scientific_journal-3226 19 35 the the DET american_scientific_journal-3226 19 36 entire entire ADJ american_scientific_journal-3226 19 37 picture picture NOUN american_scientific_journal-3226 19 38 [ [ X american_scientific_journal-3226 19 39 2,3 2,3 NUM american_scientific_journal-3226 19 40 ] ] PUNCT american_scientific_journal-3226 19 41 . . PUNCT american_scientific_journal-3226 20 1 translocation translocation VERB american_scientific_journal-3226 20 2 the the DET american_scientific_journal-3226 20 3 bcl-2 bcl-2 NOUN american_scientific_journal-3226 20 4 oncogene oncogene NOUN american_scientific_journal-3226 20 5 on on ADP american_scientific_journal-3226 20 6 chromosome chromosome NOUN american_scientific_journal-3226 20 7 18 18 NUM american_scientific_journal-3226 20 8 , , PUNCT american_scientific_journal-3226 20 9 giving give VERB american_scientific_journal-3226 20 10 rise rise NOUN american_scientific_journal-3226 20 11 to to ADP american_scientific_journal-3226 20 12 activation activation NOUN american_scientific_journal-3226 20 13 of of ADP american_scientific_journal-3226 20 14 the the DET american_scientific_journal-3226 20 15 bcl-2 bcl-2 PUNCT american_scientific_journal-3226 20 16 gene gene NOUN american_scientific_journal-3226 20 17 , , PUNCT american_scientific_journal-3226 20 18 with with ADP american_scientific_journal-3226 20 19 increased increase VERB american_scientific_journal-3226 20 20 production production NOUN american_scientific_journal-3226 20 21 of of ADP american_scientific_journal-3226 20 22 mrna mrna PROPN american_scientific_journal-3226 20 23 and and CCONJ american_scientific_journal-3226 20 24 protein protein NOUN american_scientific_journal-3226 20 25 [ [ X american_scientific_journal-3226 20 26 4 4 NUM american_scientific_journal-3226 20 27 ] ] PUNCT american_scientific_journal-3226 20 28 . . PUNCT american_scientific_journal-3226 21 1 bcl-2 bcl-2 PRON american_scientific_journal-3226 21 2 is be AUX american_scientific_journal-3226 21 3 an an DET american_scientific_journal-3226 21 4 oncogene oncogene NOUN american_scientific_journal-3226 21 5 with with ADP american_scientific_journal-3226 21 6 anti anti ADJ american_scientific_journal-3226 21 7 - - ADJ american_scientific_journal-3226 21 8 apoptotic apoptotic ADJ american_scientific_journal-3226 21 9 activity activity NOUN american_scientific_journal-3226 21 10 . . PUNCT american_scientific_journal-3226 22 1 it it PRON american_scientific_journal-3226 22 2 has have AUX american_scientific_journal-3226 22 3 been be AUX american_scientific_journal-3226 22 4 related relate VERB american_scientific_journal-3226 22 5 to to ADP american_scientific_journal-3226 22 6 androgen androgen NOUN american_scientific_journal-3226 22 7 independent independent ADJ american_scientific_journal-3226 22 8 prostate prostate NOUN american_scientific_journal-3226 22 9 adenocarcinomas adenocarcinoma NOUN american_scientific_journal-3226 23 1 [ [ X american_scientific_journal-3226 23 2 5 5 NUM american_scientific_journal-3226 23 3 ] ] PUNCT american_scientific_journal-3226 23 4 . . PUNCT american_scientific_journal-3226 24 1 proliferative proliferative ADJ american_scientific_journal-3226 24 2 activity activity NOUN american_scientific_journal-3226 24 3 tends tend VERB american_scientific_journal-3226 24 4 to to PART american_scientific_journal-3226 24 5 be be AUX american_scientific_journal-3226 24 6 low low ADJ american_scientific_journal-3226 24 7 in in ADP american_scientific_journal-3226 24 8 prostate prostate NOUN american_scientific_journal-3226 24 9 cancer cancer NOUN american_scientific_journal-3226 24 10 and and CCONJ american_scientific_journal-3226 24 11 higher high ADJ american_scientific_journal-3226 24 12 rates rate NOUN american_scientific_journal-3226 24 13 have have AUX american_scientific_journal-3226 24 14 been be AUX american_scientific_journal-3226 24 15 related relate VERB american_scientific_journal-3226 24 16 to to ADP american_scientific_journal-3226 24 17 higher high ADJ american_scientific_journal-3226 24 18 tumor tumor NOUN american_scientific_journal-3226 24 19 stage stage NOUN american_scientific_journal-3226 24 20 and and CCONJ american_scientific_journal-3226 24 21 diseasespecific diseasespecific VERB american_scientific_journal-3226 24 22 survival survival NOUN american_scientific_journal-3226 25 1 [ [ X american_scientific_journal-3226 25 2 6 6 NUM american_scientific_journal-3226 25 3 ] ] PUNCT american_scientific_journal-3226 25 4 . . PUNCT american_scientific_journal-3226 26 1 the the DET american_scientific_journal-3226 26 2 activity activity NOUN american_scientific_journal-3226 26 3 of of ADP american_scientific_journal-3226 26 4 proliferating proliferate VERB american_scientific_journal-3226 26 5 cell cell NOUN american_scientific_journal-3226 26 6 nuclear nuclear ADJ american_scientific_journal-3226 26 7 antigen antigen NOUN american_scientific_journal-3226 26 8 has have AUX american_scientific_journal-3226 26 9 been be AUX american_scientific_journal-3226 26 10 evaluated evaluate VERB american_scientific_journal-3226 26 11 in in ADP american_scientific_journal-3226 26 12 a a DET american_scientific_journal-3226 26 13 number number NOUN american_scientific_journal-3226 26 14 of of ADP american_scientific_journal-3226 26 15 tumors tumor NOUN american_scientific_journal-3226 26 16 and and CCONJ american_scientific_journal-3226 26 17 has have AUX american_scientific_journal-3226 26 18 been be AUX american_scientific_journal-3226 26 19 related relate VERB american_scientific_journal-3226 26 20 to to PART american_scientific_journal-3226 26 21 prognosis prognosis NOUN american_scientific_journal-3226 26 22 [ [ X american_scientific_journal-3226 26 23 7 7 NUM american_scientific_journal-3226 26 24 ] ] PUNCT american_scientific_journal-3226 26 25 . . PUNCT american_scientific_journal-3226 27 1 the the DET american_scientific_journal-3226 27 2 diagnosis diagnosis NOUN american_scientific_journal-3226 27 3 of of ADP american_scientific_journal-3226 27 4 prostatic prostatic ADJ american_scientific_journal-3226 27 5 carcinoma carcinoma NOUN american_scientific_journal-3226 27 6 is be AUX american_scientific_journal-3226 27 7 based base VERB american_scientific_journal-3226 27 8 on on ADP american_scientific_journal-3226 27 9 histopathological histopathological ADJ american_scientific_journal-3226 27 10 examination examination NOUN american_scientific_journal-3226 27 11 of of ADP american_scientific_journal-3226 27 12 tissue tissue NOUN american_scientific_journal-3226 27 13 obtained obtain VERB american_scientific_journal-3226 27 14 from from ADP american_scientific_journal-3226 27 15 the the DET american_scientific_journal-3226 27 16 prostate prostate NOUN american_scientific_journal-3226 27 17 gland gland NOUN american_scientific_journal-3226 27 18 . . PUNCT american_scientific_journal-3226 28 1 a a DET american_scientific_journal-3226 28 2 key key ADJ american_scientific_journal-3226 28 3 feature feature NOUN american_scientific_journal-3226 28 4 in in ADP american_scientific_journal-3226 28 5 a a DET american_scientific_journal-3226 28 6 histopathological histopathological ADJ american_scientific_journal-3226 28 7 report report NOUN american_scientific_journal-3226 28 8 of of ADP american_scientific_journal-3226 28 9 cancer cancer NOUN american_scientific_journal-3226 28 10 is be AUX american_scientific_journal-3226 28 11 the the DET american_scientific_journal-3226 28 12 grading grading NOUN american_scientific_journal-3226 28 13 of of ADP american_scientific_journal-3226 28 14 the the DET american_scientific_journal-3226 28 15 aggressiveness aggressiveness NOUN american_scientific_journal-3226 28 16 . . PUNCT american_scientific_journal-3226 29 1 for for ADP american_scientific_journal-3226 29 2 prostatic prostatic ADJ american_scientific_journal-3226 29 3 carcinoma carcinoma NOUN american_scientific_journal-3226 29 4 , , PUNCT american_scientific_journal-3226 29 5 the the DET american_scientific_journal-3226 29 6 most most ADV american_scientific_journal-3226 29 7 widely widely ADV american_scientific_journal-3226 29 8 used use VERB american_scientific_journal-3226 29 9 method method NOUN american_scientific_journal-3226 29 10 for for SCONJ american_scientific_journal-3226 29 11 this this DET american_scientific_journal-3226 29 12 grading grading NOUN american_scientific_journal-3226 29 13 was be AUX american_scientific_journal-3226 29 14 developed develop VERB american_scientific_journal-3226 29 15 by by ADP american_scientific_journal-3226 29 16 donald donald PROPN american_scientific_journal-3226 29 17 gleason gleason PROPN american_scientific_journal-3226 29 18 , , PUNCT american_scientific_journal-3226 29 19 and and CCONJ american_scientific_journal-3226 29 20 is be AUX american_scientific_journal-3226 29 21 known know VERB american_scientific_journal-3226 29 22 as as ADP american_scientific_journal-3226 29 23 the the DET american_scientific_journal-3226 29 24 gleason gleason PROPN american_scientific_journal-3226 29 25 scoring scoring NOUN american_scientific_journal-3226 29 26 system system NOUN american_scientific_journal-3226 29 27 [ [ X american_scientific_journal-3226 29 28 8,9 8,9 NUM american_scientific_journal-3226 29 29 ] ] PUNCT american_scientific_journal-3226 29 30 . . PUNCT american_scientific_journal-3226 30 1 the the DET american_scientific_journal-3226 30 2 gleason gleason PROPN american_scientific_journal-3226 30 3 grading grade VERB american_scientific_journal-3226 30 4 system system NOUN american_scientific_journal-3226 30 5 remains remain VERB american_scientific_journal-3226 30 6 one one NUM american_scientific_journal-3226 30 7 of of ADP american_scientific_journal-3226 30 8 the the DET american_scientific_journal-3226 30 9 important important ADJ american_scientific_journal-3226 30 10 prognostic prognostic ADJ american_scientific_journal-3226 30 11 and and CCONJ american_scientific_journal-3226 30 12 predicting predict VERB american_scientific_journal-3226 30 13 factors factor NOUN american_scientific_journal-3226 30 14 for for ADP american_scientific_journal-3226 30 15 prostate prostate NOUN american_scientific_journal-3226 30 16 carcinoma carcinoma NOUN american_scientific_journal-3226 30 17 [ [ X american_scientific_journal-3226 30 18 10 10 NUM american_scientific_journal-3226 30 19 ] ] PUNCT american_scientific_journal-3226 30 20 . . PUNCT american_scientific_journal-3226 31 1 more more ADV american_scientific_journal-3226 31 2 recently recently ADV american_scientific_journal-3226 31 3 , , PUNCT american_scientific_journal-3226 31 4 the the DET american_scientific_journal-3226 31 5 emergence emergence NOUN american_scientific_journal-3226 31 6 of of ADP american_scientific_journal-3226 31 7 molecular molecular ADJ american_scientific_journal-3226 31 8 medicine medicine NOUN american_scientific_journal-3226 31 9 has have AUX american_scientific_journal-3226 31 10 resulted result VERB american_scientific_journal-3226 31 11 in in ADP american_scientific_journal-3226 31 12 the the DET american_scientific_journal-3226 31 13 increased increase VERB american_scientific_journal-3226 31 14 use use NOUN american_scientific_journal-3226 31 15 of of ADP american_scientific_journal-3226 31 16 techniques technique NOUN american_scientific_journal-3226 31 17 able able ADJ american_scientific_journal-3226 31 18 to to PART american_scientific_journal-3226 31 19 quantitate quantitate VERB american_scientific_journal-3226 31 20 levels level NOUN american_scientific_journal-3226 31 21 of of ADP american_scientific_journal-3226 31 22 rna rna NOUN american_scientific_journal-3226 31 23 in in ADP american_scientific_journal-3226 31 24 clinical clinical ADJ american_scientific_journal-3226 31 25 diagnostics diagnostic NOUN american_scientific_journal-3226 31 26 [ [ X american_scientific_journal-3226 31 27 11 11 NUM american_scientific_journal-3226 31 28 ] ] PUNCT american_scientific_journal-3226 31 29 . . PUNCT american_scientific_journal-3226 32 1 quantitative quantitative ADJ american_scientific_journal-3226 32 2 real real ADJ american_scientific_journal-3226 32 3 - - PUNCT american_scientific_journal-3226 32 4 time time NOUN american_scientific_journal-3226 32 5 pcr pcr NOUN american_scientific_journal-3226 32 6 ( ( PUNCT american_scientific_journal-3226 32 7 qpcr qpcr ADV american_scientific_journal-3226 32 8 ) ) PUNCT american_scientific_journal-3226 32 9 has have AUX american_scientific_journal-3226 32 10 become become VERB american_scientific_journal-3226 32 11 a a DET american_scientific_journal-3226 32 12 useful useful ADJ american_scientific_journal-3226 32 13 tool tool NOUN american_scientific_journal-3226 32 14 for for ADP american_scientific_journal-3226 32 15 validation validation NOUN american_scientific_journal-3226 32 16 and and CCONJ american_scientific_journal-3226 32 17 reduction reduction NOUN american_scientific_journal-3226 32 18 of of ADP american_scientific_journal-3226 32 19 data datum NOUN american_scientific_journal-3226 32 20 produced produce VERB american_scientific_journal-3226 32 21 from from ADP american_scientific_journal-3226 32 22 microarray microarray NOUN american_scientific_journal-3226 32 23 studies study NOUN american_scientific_journal-3226 32 24 [ [ X american_scientific_journal-3226 32 25 12,13 12,13 NUM american_scientific_journal-3226 32 26 ] ] PUNCT american_scientific_journal-3226 32 27 . . PUNCT american_scientific_journal-3226 33 1 many many ADJ american_scientific_journal-3226 33 2 pca pca PROPN american_scientific_journal-3226 33 3 biomarker biomarker NOUN american_scientific_journal-3226 33 4 studies study NOUN american_scientific_journal-3226 33 5 employ employ VERB american_scientific_journal-3226 33 6 microarrays microarray NOUN american_scientific_journal-3226 33 7 to to PART american_scientific_journal-3226 33 8 identify identify VERB american_scientific_journal-3226 33 9 profiles profile NOUN american_scientific_journal-3226 33 10 of of ADP american_scientific_journal-3226 33 11 the the DET american_scientific_journal-3226 33 12 disease disease NOUN american_scientific_journal-3226 33 13 and and CCONJ american_scientific_journal-3226 33 14 its its PRON american_scientific_journal-3226 33 15 progression progression NOUN american_scientific_journal-3226 33 16 [ [ X american_scientific_journal-3226 33 17 14,15,16 14,15,16 NUM american_scientific_journal-3226 33 18 ] ] PUNCT american_scientific_journal-3226 33 19 . . PUNCT american_scientific_journal-3226 34 1 the the DET american_scientific_journal-3226 34 2 aim aim NOUN american_scientific_journal-3226 34 3 of of ADP american_scientific_journal-3226 34 4 this this DET american_scientific_journal-3226 34 5 study study NOUN american_scientific_journal-3226 34 6 was be AUX american_scientific_journal-3226 34 7 to to PART american_scientific_journal-3226 34 8 evaluate evaluate VERB american_scientific_journal-3226 34 9 tumor tumor NOUN american_scientific_journal-3226 34 10 proliferation proliferation NOUN american_scientific_journal-3226 34 11 and and CCONJ american_scientific_journal-3226 34 12 the the DET american_scientific_journal-3226 34 13 expression expression NOUN american_scientific_journal-3226 34 14 of of ADP american_scientific_journal-3226 34 15 the the DET american_scientific_journal-3226 34 16 proto proto NOUN american_scientific_journal-3226 34 17 - - PUNCT american_scientific_journal-3226 34 18 oncogen oncogen NOUN american_scientific_journal-3226 34 19 bcl-2 bcl-2 ADJ american_scientific_journal-3226 34 20 and and CCONJ american_scientific_journal-3226 34 21 tumor tumor NOUN american_scientific_journal-3226 34 22 suppressor suppressor NOUN american_scientific_journal-3226 34 23 gene gene NOUN american_scientific_journal-3226 34 24 p53 p53 NOUN american_scientific_journal-3226 34 25 in in ADP american_scientific_journal-3226 34 26 patients patient NOUN american_scientific_journal-3226 34 27 undergoing undergo VERB american_scientific_journal-3226 34 28 transurethral transurethral ADJ american_scientific_journal-3226 34 29 prostatectomy prostatectomy NOUN american_scientific_journal-3226 34 30 for for ADP american_scientific_journal-3226 34 31 prostate prostate NOUN american_scientific_journal-3226 34 32 carcinoma carcinoma NOUN american_scientific_journal-3226 34 33 , , PUNCT american_scientific_journal-3226 34 34 and and CCONJ american_scientific_journal-3226 34 35 to to PART american_scientific_journal-3226 34 36 define define VERB american_scientific_journal-3226 34 37 their their PRON american_scientific_journal-3226 34 38 prognostic prognostic ADJ american_scientific_journal-3226 34 39 roles role NOUN american_scientific_journal-3226 34 40 through through ADP american_scientific_journal-3226 34 41 correlation correlation NOUN american_scientific_journal-3226 34 42 with with ADP american_scientific_journal-3226 34 43 final final ADJ american_scientific_journal-3226 34 44 gleason gleason PROPN american_scientific_journal-3226 34 45 score score NOUN american_scientific_journal-3226 34 46 , , PUNCT american_scientific_journal-3226 34 47 using use VERB american_scientific_journal-3226 34 48 qrtpcr qrtpcr ADJ american_scientific_journal-3226 34 49 . . PUNCT american_scientific_journal-3226 35 1 2 2 X american_scientific_journal-3226 35 2 . . X american_scientific_journal-3226 35 3 material material NOUN american_scientific_journal-3226 35 4 and and CCONJ american_scientific_journal-3226 35 5 method method VERB american_scientific_journal-3226 35 6 forty forty NUM american_scientific_journal-3226 35 7 patients patient NOUN american_scientific_journal-3226 35 8 who who PRON american_scientific_journal-3226 35 9 were be AUX american_scientific_journal-3226 35 10 treated treat VERB american_scientific_journal-3226 35 11 by by ADP american_scientific_journal-3226 35 12 transurethral transurethral ADJ american_scientific_journal-3226 35 13 resection resection NOUN american_scientific_journal-3226 35 14 of of ADP american_scientific_journal-3226 35 15 the the DET american_scientific_journal-3226 35 16 prostate prostate NOUN american_scientific_journal-3226 35 17 in in ADP american_scientific_journal-3226 35 18 2015 2015 NUM american_scientific_journal-3226 35 19 to to ADP american_scientific_journal-3226 35 20 2016 2016 NUM american_scientific_journal-3226 35 21 for for ADP american_scientific_journal-3226 35 22 adenocarcinoma adenocarcinoma NOUN american_scientific_journal-3226 35 23 prostate prostate NOUN american_scientific_journal-3226 35 24 were be AUX american_scientific_journal-3226 35 25 analyzed analyze VERB american_scientific_journal-3226 35 26 according accord VERB american_scientific_journal-3226 35 27 to to ADP american_scientific_journal-3226 35 28 histopathological histopathological ADJ american_scientific_journal-3226 35 29 standard standard ADJ american_scientific_journal-3226 35 30 methods method NOUN american_scientific_journal-3226 35 31 . . PUNCT american_scientific_journal-3226 36 1 fixation fixation NOUN american_scientific_journal-3226 36 2 of of ADP american_scientific_journal-3226 36 3 tissue tissue NOUN american_scientific_journal-3226 36 4 sample sample NOUN american_scientific_journal-3226 36 5 using use VERB american_scientific_journal-3226 36 6 normal normal ADJ american_scientific_journal-3226 36 7 buffer buffer NOUN american_scientific_journal-3226 36 8 formalin formalin NOUN american_scientific_journal-3226 36 9 10 10 NUM american_scientific_journal-3226 36 10 % % NOUN american_scientific_journal-3226 36 11 . . PUNCT american_scientific_journal-3226 37 1 tissue tissue NOUN american_scientific_journal-3226 37 2 preparation preparation NOUN american_scientific_journal-3226 37 3 from from ADP american_scientific_journal-3226 37 4 ffpe ffpe NOUN american_scientific_journal-3226 37 5 as as ADP american_scientific_journal-3226 37 6 previous previous ADJ american_scientific_journal-3226 37 7 describe describe NOUN american_scientific_journal-3226 37 8 [ [ X american_scientific_journal-3226 37 9 17 17 NUM american_scientific_journal-3226 37 10 ] ] PUNCT american_scientific_journal-3226 37 11 . . PUNCT american_scientific_journal-3226 38 1 total total ADJ american_scientific_journal-3226 38 2 rna rna NOUN american_scientific_journal-3226 38 3 extraction extraction NOUN american_scientific_journal-3226 38 4 using use VERB american_scientific_journal-3226 38 5 qiasymphony qiasymphony PROPN american_scientific_journal-3226 38 6 instrument instrument NOUN american_scientific_journal-3226 38 7 with with ADP american_scientific_journal-3226 38 8 the the DET american_scientific_journal-3226 38 9 rneasyòffpe rneasyòffpe NOUN american_scientific_journal-3226 38 10 kit kit NOUN american_scientific_journal-3226 38 11 ( ( PUNCT american_scientific_journal-3226 38 12 qiagen qiagen PROPN american_scientific_journal-3226 38 13 ) ) PUNCT american_scientific_journal-3226 38 14 following follow VERB american_scientific_journal-3226 38 15 the the DET american_scientific_journal-3226 38 16 instructions instruction NOUN american_scientific_journal-3226 38 17 suggested suggest VERB american_scientific_journal-3226 38 18 by by ADP american_scientific_journal-3226 38 19 the the DET american_scientific_journal-3226 38 20 manufacturer manufacturer NOUN american_scientific_journal-3226 38 21 . . PUNCT american_scientific_journal-3226 39 1 reverse reverse ADJ american_scientific_journal-3226 39 2 transcription transcription NOUN american_scientific_journal-3226 39 3 and and CCONJ american_scientific_journal-3226 39 4 quantitative quantitative ADJ american_scientific_journal-3226 39 5 real real ADJ american_scientific_journal-3226 39 6 - - PUNCT american_scientific_journal-3226 39 7 time time NOUN american_scientific_journal-3226 39 8 polymerase polymerase NOUN american_scientific_journal-3226 39 9 chain chain NOUN american_scientific_journal-3226 39 10 reaction reaction NOUN american_scientific_journal-3226 39 11 ( ( PUNCT american_scientific_journal-3226 39 12 qrtpcr qrtpcr PROPN american_scientific_journal-3226 39 13 ) ) PUNCT american_scientific_journal-3226 39 14 in in ADP american_scientific_journal-3226 39 15 one one NUM american_scientific_journal-3226 39 16 step step NOUN american_scientific_journal-3226 39 17 using use VERB american_scientific_journal-3226 39 18 rotor rotor NOUN american_scientific_journal-3226 39 19 gen gen PROPN american_scientific_journal-3226 39 20 q q PROPN american_scientific_journal-3226 39 21 ( ( PUNCT american_scientific_journal-3226 39 22 qiagen qiagen NOUN american_scientific_journal-3226 39 23 ) ) PUNCT american_scientific_journal-3226 39 24 perform perform NOUN american_scientific_journal-3226 39 25 by by ADP american_scientific_journal-3226 39 26 adding add VERB american_scientific_journal-3226 39 27 2µl 2µl ADJ american_scientific_journal-3226 39 28 total total ADJ american_scientific_journal-3226 39 29 rna rna NOUN american_scientific_journal-3226 39 30 to to PART american_scientific_journal-3226 39 31 master master NOUN american_scientific_journal-3226 39 32 mix mix NOUN american_scientific_journal-3226 39 33 ( ( PUNCT american_scientific_journal-3226 39 34 qiagen qiagen PROPN american_scientific_journal-3226 39 35 ) ) PUNCT american_scientific_journal-3226 39 36 ( ( PUNCT american_scientific_journal-3226 39 37 15 15 NUM american_scientific_journal-3226 39 38 µl µl NOUN american_scientific_journal-3226 39 39 ) ) PUNCT american_scientific_journal-3226 39 40 consisting consist VERB american_scientific_journal-3226 39 41 of of ADP american_scientific_journal-3226 39 42 the the DET american_scientific_journal-3226 39 43 following follow VERB american_scientific_journal-3226 39 44 components component NOUN american_scientific_journal-3226 39 45 : : PUNCT american_scientific_journal-3226 39 46 5.0 5.0 NUM american_scientific_journal-3226 39 47 µl µl NOUN american_scientific_journal-3226 39 48 of of ADP american_scientific_journal-3226 39 49 5 5 NUM american_scientific_journal-3226 39 50 reaction reaction NOUN american_scientific_journal-3226 39 51 buffer buffer NOUN american_scientific_journal-3226 39 52 , , PUNCT american_scientific_journal-3226 39 53 0.5 0.5 NUM american_scientific_journal-3226 39 54 µl µl NOUN american_scientific_journal-3226 39 55 of of ADP american_scientific_journal-3226 39 56 dntp dntp NOUN american_scientific_journal-3226 39 57 , , PUNCT american_scientific_journal-3226 39 58 0.1 0.1 NUM american_scientific_journal-3226 39 59 µl µl NOUN american_scientific_journal-3226 39 60 of of ADP american_scientific_journal-3226 39 61 m m NOUN american_scientific_journal-3226 39 62 - - PUNCT american_scientific_journal-3226 39 63 mlv mlv ADJ american_scientific_journal-3226 39 64 reverse reverse NOUN american_scientific_journal-3226 39 65 transcriptase transcriptase NOUN american_scientific_journal-3226 39 66 , , PUNCT american_scientific_journal-3226 39 67 ( ( PUNCT american_scientific_journal-3226 39 68 moloney moloney PROPN american_scientific_journal-3226 39 69 murine murine PROPN american_scientific_journal-3226 39 70 leukemia leukemia PROPN american_scientific_journal-3226 39 71 virus virus NOUN american_scientific_journal-3226 39 72 reverse reverse ADJ american_scientific_journal-3226 39 73 transcriptase transcriptase NOUN american_scientific_journal-3226 39 74 ; ; PUNCT american_scientific_journal-3226 39 75 200 200 NUM american_scientific_journal-3226 39 76 u/µl u/µl NOUN american_scientific_journal-3226 39 77 ; ; PUNCT american_scientific_journal-3226 39 78 usb usb NOUN american_scientific_journal-3226 39 79 ) ) PUNCT american_scientific_journal-3226 39 80 , , PUNCT american_scientific_journal-3226 39 81 and and CCONJ american_scientific_journal-3226 39 82 9.4 9.4 NUM american_scientific_journal-3226 39 83 µl µl NOUN american_scientific_journal-3226 39 84 of of ADP american_scientific_journal-3226 39 85 dh2o dh2o NOUN american_scientific_journal-3226 39 86 . . PUNCT american_scientific_journal-3226 40 1 10 10 NUM american_scientific_journal-3226 40 2 µl µl NOUN american_scientific_journal-3226 40 3 of of ADP american_scientific_journal-3226 40 4 sybrtmgreen sybrtmgreen NOUN american_scientific_journal-3226 40 5 ( ( PUNCT american_scientific_journal-3226 40 6 qiagen qiagen PROPN american_scientific_journal-3226 40 7 ) ) PUNCT american_scientific_journal-3226 40 8 , , PUNCT american_scientific_journal-3226 40 9 1.5 1.5 NUM american_scientific_journal-3226 40 10 l l NOUN american_scientific_journal-3226 40 11 of of ADP american_scientific_journal-3226 40 12 each each DET american_scientific_journal-3226 40 13 primer primer NOUN american_scientific_journal-3226 40 14 ( ( PUNCT american_scientific_journal-3226 40 15 see see VERB american_scientific_journal-3226 40 16 table table NOUN american_scientific_journal-3226 40 17 1 1 NUM american_scientific_journal-3226 40 18 ) ) PUNCT american_scientific_journal-3226 40 19 . . PUNCT american_scientific_journal-3226 41 1 the the DET american_scientific_journal-3226 41 2 housekeeping housekeeping NOUN american_scientific_journal-3226 41 3 genes gene NOUN american_scientific_journal-3226 41 4 like like ADP american_scientific_journal-3226 41 5 gapdh gapdh NOUN american_scientific_journal-3226 41 6 should should AUX american_scientific_journal-3226 41 7 be be AUX american_scientific_journal-3226 41 8 used use VERB american_scientific_journal-3226 41 9 as as ADP american_scientific_journal-3226 41 10 controls control NOUN american_scientific_journal-3226 41 11 for for ADP american_scientific_journal-3226 41 12 normalization normalization NOUN american_scientific_journal-3226 41 13 ( ( PUNCT american_scientific_journal-3226 41 14 see see VERB american_scientific_journal-3226 41 15 table table NOUN american_scientific_journal-3226 41 16 1 1 NUM american_scientific_journal-3226 41 17 ) ) PUNCT american_scientific_journal-3226 41 18 . . PUNCT american_scientific_journal-3226 42 1 running run VERB american_scientific_journal-3226 42 2 amplification amplification NOUN american_scientific_journal-3226 42 3 as as SCONJ american_scientific_journal-3226 42 4 described describe VERB american_scientific_journal-3226 42 5 previously previously ADV american_scientific_journal-3226 42 6 [ [ X american_scientific_journal-3226 42 7 18 18 NUM american_scientific_journal-3226 42 8 ] ] PUNCT american_scientific_journal-3226 42 9 . . PUNCT american_scientific_journal-3226 43 1 analysis analysis NOUN american_scientific_journal-3226 43 2 procedures procedure NOUN american_scientific_journal-3226 43 3 supported support VERB american_scientific_journal-3226 43 4 by by ADP american_scientific_journal-3226 43 5 rotor rotor NOUN american_scientific_journal-3226 43 6 - - PUNCT american_scientific_journal-3226 43 7 gene gene NOUN american_scientific_journal-3226 43 8 q q PROPN american_scientific_journal-3226 43 9 software software NOUN american_scientific_journal-3226 43 10 . . PUNCT american_scientific_journal-3226 44 1 american american ADJ american_scientific_journal-3226 44 2 scientific scientific ADJ american_scientific_journal-3226 44 3 research research PROPN american_scientific_journal-3226 44 4 journal journal NOUN american_scientific_journal-3226 44 5 for for ADP american_scientific_journal-3226 44 6 engineering engineering NOUN american_scientific_journal-3226 44 7 , , PUNCT american_scientific_journal-3226 44 8 technology technology NOUN american_scientific_journal-3226 44 9 , , PUNCT american_scientific_journal-3226 44 10 and and CCONJ american_scientific_journal-3226 44 11 sciences science NOUN american_scientific_journal-3226 44 12 ( ( PUNCT american_scientific_journal-3226 44 13 asrjets asrjet NOUN american_scientific_journal-3226 44 14 ) ) PUNCT american_scientific_journal-3226 44 15 ( ( PUNCT american_scientific_journal-3226 44 16 2017 2017 NUM american_scientific_journal-3226 44 17 ) ) PUNCT american_scientific_journal-3226 44 18 volume volume NOUN american_scientific_journal-3226 44 19 35 35 NUM american_scientific_journal-3226 44 20 , , PUNCT american_scientific_journal-3226 44 21 no no DET american_scientific_journal-3226 44 22 1 1 NUM american_scientific_journal-3226 44 23 , , PUNCT american_scientific_journal-3226 44 24 pp pp ADV american_scientific_journal-3226 44 25 8 8 NUM american_scientific_journal-3226 44 26 - - SYM american_scientific_journal-3226 44 27 14 14 NUM american_scientific_journal-3226 44 28 10 10 NUM american_scientific_journal-3226 44 29 table table NOUN american_scientific_journal-3226 44 30 1 1 NUM american_scientific_journal-3226 44 31 : : PUNCT american_scientific_journal-3226 44 32 the the DET american_scientific_journal-3226 44 33 primer primer NOUN american_scientific_journal-3226 44 34 used use VERB american_scientific_journal-3226 44 35 for for ADP american_scientific_journal-3226 44 36 reverse reverse ADJ american_scientific_journal-3226 44 37 transcription transcription NOUN american_scientific_journal-3226 44 38 gen gen NOUN american_scientific_journal-3226 44 39 primer primer NOUN american_scientific_journal-3226 44 40 p53 p53 NOUN american_scientific_journal-3226 44 41 f5’gag f5’gag NOUN american_scientific_journal-3226 44 42 ctg ctg X american_scientific_journal-3226 44 43 aat aat NOUN american_scientific_journal-3226 44 44 gag gag NOUN american_scientific_journal-3226 44 45 gcc gcc NOUN american_scientific_journal-3226 44 46 ttgg ttgg NOUN american_scientific_journal-3226 44 47 a3 a3 NOUN american_scientific_journal-3226 44 48 ’ ' PUNCT american_scientific_journal-3226 44 49 r r NOUN american_scientific_journal-3226 44 50 : : PUNCT american_scientific_journal-3226 44 51 5’ctg 5’ctg NUM american_scientific_journal-3226 44 52 agt agt PROPN american_scientific_journal-3226 44 53 cag cag PROPN american_scientific_journal-3226 44 54 gcc gcc PROPN american_scientific_journal-3226 44 55 ctt ctt PROPN american_scientific_journal-3226 44 56 ccg ccg PROPN american_scientific_journal-3226 44 57 tct tct PROPN american_scientific_journal-3226 44 58 t3 t3 PROPN american_scientific_journal-3226 44 59 ’ ' PUNCT american_scientific_journal-3226 44 60 bcl-2 bcl-2 NUM american_scientific_journal-3226 44 61 f f X american_scientific_journal-3226 44 62 : : PUNCT american_scientific_journal-3226 44 63 5’ttg 5’ttg NUM american_scientific_journal-3226 44 64 tgg tgg PROPN american_scientific_journal-3226 44 65 cct cct PROPN american_scientific_journal-3226 44 66 tct tct PROPN american_scientific_journal-3226 44 67 ttg ttg PROPN american_scientific_journal-3226 44 68 agt agt PROPN american_scientific_journal-3226 44 69 tcg tcg PROPN american_scientific_journal-3226 44 70 gtg3 gtg3 PROPN american_scientific_journal-3226 44 71 ’ ' PUNCT american_scientific_journal-3226 45 1 r r NOUN american_scientific_journal-3226 45 2 : : PUNCT american_scientific_journal-3226 45 3 5’ggt 5’ggt NUM american_scientific_journal-3226 45 4 gcc gcc NOUN american_scientific_journal-3226 45 5 ggt ggt PROPN american_scientific_journal-3226 45 6 tca tca PROPN american_scientific_journal-3226 45 7 ggt ggt PROPN american_scientific_journal-3226 45 8 act act PROPN american_scientific_journal-3226 45 9 cag cag PROPN american_scientific_journal-3226 45 10 tca3 tca3 PROPN american_scientific_journal-3226 45 11 ’ ' PUNCT american_scientific_journal-3226 45 12 gapgh gapgh PROPN american_scientific_journal-3226 46 1 f f X american_scientific_journal-3226 46 2 : : PUNCT american_scientific_journal-3226 47 1 5’tga 5’tga NUM american_scientific_journal-3226 47 2 tga tga PROPN american_scientific_journal-3226 47 3 cat cat PROPN american_scientific_journal-3226 47 4 caa caa PROPN american_scientific_journal-3226 47 5 gaa gaa PROPN american_scientific_journal-3226 47 6 ggt ggt PROPN american_scientific_journal-3226 47 7 ggt ggt PROPN american_scientific_journal-3226 47 8 gaa3 gaa3 PROPN american_scientific_journal-3226 47 9 ’ ' PUNCT american_scientific_journal-3226 48 1 r r NOUN american_scientific_journal-3226 48 2 : : PUNCT american_scientific_journal-3226 48 3 5’ttc 5’ttc NUM american_scientific_journal-3226 48 4 ttg ttg NOUN american_scientific_journal-3226 48 5 gag gag NOUN american_scientific_journal-3226 48 6 gcc gcc NOUN american_scientific_journal-3226 48 7 atg atg PROPN american_scientific_journal-3226 48 8 tgg tgg PROPN american_scientific_journal-3226 48 9 gcc gcc PROPN american_scientific_journal-3226 48 10 at3 at3 NOUN american_scientific_journal-3226 48 11 ’ ' PUNCT american_scientific_journal-3226 48 12 3 3 NUM american_scientific_journal-3226 48 13 . . NOUN american_scientific_journal-3226 48 14 result result NOUN american_scientific_journal-3226 48 15 in in ADP american_scientific_journal-3226 48 16 40 40 NUM american_scientific_journal-3226 48 17 sample sample NOUN american_scientific_journal-3226 48 18 divided divide VERB american_scientific_journal-3226 48 19 into into ADP american_scientific_journal-3226 48 20 two two NUM american_scientific_journal-3226 48 21 groups group NOUN american_scientific_journal-3226 48 22 , , PUNCT american_scientific_journal-3226 48 23 low low ADJ american_scientific_journal-3226 48 24 gleason gleason PROPN american_scientific_journal-3226 48 25 score score NOUN american_scientific_journal-3226 48 26 ( ( PUNCT american_scientific_journal-3226 48 27 2 2 NUM american_scientific_journal-3226 48 28 - - SYM american_scientific_journal-3226 48 29 6 6 NUM american_scientific_journal-3226 48 30 ) ) PUNCT american_scientific_journal-3226 48 31 is be AUX american_scientific_journal-3226 48 32 28 28 NUM american_scientific_journal-3226 48 33 ( ( PUNCT american_scientific_journal-3226 48 34 70 70 NUM american_scientific_journal-3226 48 35 % % NOUN american_scientific_journal-3226 48 36 ) ) PUNCT american_scientific_journal-3226 48 37 and and CCONJ american_scientific_journal-3226 48 38 high high ADJ american_scientific_journal-3226 48 39 gleason gleason PROPN american_scientific_journal-3226 48 40 score score NOUN american_scientific_journal-3226 48 41 ( ( PUNCT american_scientific_journal-3226 48 42 7 7 NUM american_scientific_journal-3226 48 43 - - SYM american_scientific_journal-3226 48 44 10 10 NUM american_scientific_journal-3226 48 45 ) ) PUNCT american_scientific_journal-3226 48 46 is be AUX american_scientific_journal-3226 48 47 12(30 12(30 NUM american_scientific_journal-3226 48 48 % % NOUN american_scientific_journal-3226 48 49 ) ) PUNCT american_scientific_journal-3226 48 50 . . PUNCT american_scientific_journal-3226 49 1 median median ADJ american_scientific_journal-3226 49 2 age age NOUN american_scientific_journal-3226 49 3 in in ADP american_scientific_journal-3226 49 4 low low PROPN american_scientific_journal-3226 49 5 gleason gleason PROPN american_scientific_journal-3226 49 6 score score NOUN american_scientific_journal-3226 49 7 is be AUX american_scientific_journal-3226 49 8 70 70 NUM american_scientific_journal-3226 49 9 years year NOUN american_scientific_journal-3226 49 10 and and CCONJ american_scientific_journal-3226 49 11 high high ADJ american_scientific_journal-3226 49 12 gleason gleason PROPN american_scientific_journal-3226 49 13 score score NOUN american_scientific_journal-3226 49 14 is be AUX american_scientific_journal-3226 49 15 67.5 67.5 NUM american_scientific_journal-3226 49 16 years year NOUN american_scientific_journal-3226 49 17 . . PUNCT american_scientific_journal-3226 50 1 median median ADJ american_scientific_journal-3226 50 2 psa psa NOUN american_scientific_journal-3226 50 3 before before ADP american_scientific_journal-3226 50 4 turp turp NOUN american_scientific_journal-3226 50 5 in in ADP american_scientific_journal-3226 50 6 low low ADJ american_scientific_journal-3226 50 7 gs gs PROPN american_scientific_journal-3226 50 8 is be AUX american_scientific_journal-3226 50 9 12,15 12,15 NUM american_scientific_journal-3226 50 10 ng% ng% NUM american_scientific_journal-3226 50 11 and and CCONJ american_scientific_journal-3226 50 12 high high ADJ american_scientific_journal-3226 50 13 gleason gleason PROPN american_scientific_journal-3226 50 14 score score NOUN american_scientific_journal-3226 50 15 is be AUX american_scientific_journal-3226 50 16 12,05 12,05 NUM american_scientific_journal-3226 50 17 ng% ng% NOUN american_scientific_journal-3226 50 18 . . PUNCT american_scientific_journal-3226 51 1 most most ADJ american_scientific_journal-3226 51 2 of of ADP american_scientific_journal-3226 51 3 clinical clinical ADJ american_scientific_journal-3226 51 4 staging staging NOUN american_scientific_journal-3226 51 5 tumor tumor NOUN american_scientific_journal-3226 51 6 is be AUX american_scientific_journal-3226 51 7 t1c t1c PRON american_scientific_journal-3226 51 8 . . PUNCT american_scientific_journal-3226 52 1 mean mean PROPN american_scientific_journal-3226 52 2 of of ADP american_scientific_journal-3226 52 3 mrna mrna PROPN american_scientific_journal-3226 52 4 bcl-2 bcl-2 PUNCT american_scientific_journal-3226 52 5 expression expression NOUN american_scientific_journal-3226 52 6 in in ADP american_scientific_journal-3226 52 7 low low ADJ american_scientific_journal-3226 52 8 gleason gleason PROPN american_scientific_journal-3226 52 9 score score NOUN american_scientific_journal-3226 52 10 is be AUX american_scientific_journal-3226 52 11 80.34 80.34 NUM american_scientific_journal-3226 52 12 ± ± NUM american_scientific_journal-3226 52 13 117.60 117.60 NUM american_scientific_journal-3226 52 14 and and CCONJ american_scientific_journal-3226 52 15 in in ADP american_scientific_journal-3226 52 16 high high ADJ american_scientific_journal-3226 52 17 gleason gleason PROPN american_scientific_journal-3226 52 18 score score NOUN american_scientific_journal-3226 52 19 is be AUX american_scientific_journal-3226 52 20 31.01 31.01 NUM american_scientific_journal-3226 52 21 ± ± NUM american_scientific_journal-3226 52 22 23.48 23.48 NUM american_scientific_journal-3226 52 23 . . PUNCT american_scientific_journal-3226 53 1 bivariate bivariate ADJ american_scientific_journal-3226 53 2 analysis analysis NOUN american_scientific_journal-3226 53 3 mrna mrna PROPN american_scientific_journal-3226 53 4 bcl-2 bcl-2 PRON american_scientific_journal-3226 53 5 correlate correlate VERB american_scientific_journal-3226 53 6 not not PART american_scientific_journal-3226 53 7 significant significant ADJ american_scientific_journal-3226 53 8 to to ADP american_scientific_journal-3226 53 9 gleason gleason PROPN american_scientific_journal-3226 53 10 score score VERB american_scientific_journal-3226 53 11 although although SCONJ american_scientific_journal-3226 53 12 the the DET american_scientific_journal-3226 53 13 trend trend NOUN american_scientific_journal-3226 53 14 is be AUX american_scientific_journal-3226 53 15 rising rise VERB american_scientific_journal-3226 53 16 in in ADP american_scientific_journal-3226 53 17 high high ADJ american_scientific_journal-3226 53 18 gleason gleason PROPN american_scientific_journal-3226 53 19 score score NOUN american_scientific_journal-3226 53 20 . . PUNCT american_scientific_journal-3226 54 1 mean mean PROPN american_scientific_journal-3226 54 2 of of ADP american_scientific_journal-3226 54 3 mrna mrna PROPN american_scientific_journal-3226 54 4 p53 p53 NOUN american_scientific_journal-3226 54 5 expression expression NOUN american_scientific_journal-3226 54 6 in in ADP american_scientific_journal-3226 54 7 low low PROPN american_scientific_journal-3226 54 8 gleason gleason PROPN american_scientific_journal-3226 54 9 score score NOUN american_scientific_journal-3226 54 10 is be AUX american_scientific_journal-3226 54 11 243.52 243.52 NUM american_scientific_journal-3226 54 12 ± ± NUM american_scientific_journal-3226 54 13 490.52 490.52 NUM american_scientific_journal-3226 54 14 and and CCONJ american_scientific_journal-3226 54 15 in in ADP american_scientific_journal-3226 54 16 high high ADJ american_scientific_journal-3226 54 17 gleason gleason PROPN american_scientific_journal-3226 54 18 score score NOUN american_scientific_journal-3226 54 19 is be AUX american_scientific_journal-3226 54 20 20.47 20.47 NUM american_scientific_journal-3226 54 21 ± ± NUM american_scientific_journal-3226 54 22 24.08 24.08 NUM american_scientific_journal-3226 54 23 . . PUNCT american_scientific_journal-3226 55 1 bivariate bivariate ADJ american_scientific_journal-3226 55 2 analysis analysis NOUN american_scientific_journal-3226 55 3 of of ADP american_scientific_journal-3226 55 4 mrna mrna PROPN american_scientific_journal-3226 55 5 p53 p53 PROPN american_scientific_journal-3226 55 6 and and CCONJ american_scientific_journal-3226 55 7 gleason gleason PROPN american_scientific_journal-3226 55 8 score score NOUN american_scientific_journal-3226 55 9 refer refer VERB american_scientific_journal-3226 55 10 to to ADP american_scientific_journal-3226 55 11 significant significant ADJ american_scientific_journal-3226 55 12 correlation correlation NOUN american_scientific_journal-3226 55 13 ( ( PUNCT american_scientific_journal-3226 55 14 p p NOUN american_scientific_journal-3226 55 15 value value NOUN american_scientific_journal-3226 55 16 < < X american_scientific_journal-3226 55 17 0,001 0,001 NUM american_scientific_journal-3226 55 18 ) ) PUNCT american_scientific_journal-3226 55 19 . . PUNCT american_scientific_journal-3226 56 1 table table NOUN american_scientific_journal-3226 56 2 2 2 NUM american_scientific_journal-3226 56 3 : : PUNCT american_scientific_journal-3226 56 4 sample sample NOUN american_scientific_journal-3226 56 5 characteristic characteristic ADJ american_scientific_journal-3226 56 6 group group NOUN american_scientific_journal-3226 56 7 variable variable NOUN american_scientific_journal-3226 56 8 gs gs ADP american_scientific_journal-3226 56 9 2 2 NUM american_scientific_journal-3226 56 10 - - SYM american_scientific_journal-3226 56 11 6 6 NUM american_scientific_journal-3226 56 12 n=28 n=28 NOUN american_scientific_journal-3226 56 13 gs gs X american_scientific_journal-3226 56 14 7 7 NUM american_scientific_journal-3226 56 15 - - SYM american_scientific_journal-3226 56 16 10 10 NUM american_scientific_journal-3226 56 17 n=12 n=12 NOUN american_scientific_journal-3226 56 18 age age NOUN american_scientific_journal-3226 56 19 median median PROPN american_scientific_journal-3226 56 20 min min PROPN american_scientific_journal-3226 56 21 - - ADJ american_scientific_journal-3226 56 22 max max PROPN american_scientific_journal-3226 56 23 psa psa PROPN american_scientific_journal-3226 56 24 median median PROPN american_scientific_journal-3226 56 25 min min PROPN american_scientific_journal-3226 56 26 - - ADJ american_scientific_journal-3226 56 27 max max PROPN american_scientific_journal-3226 56 28 tumor tumor NOUN american_scientific_journal-3226 56 29 t1c t1c NUM american_scientific_journal-3226 56 30 t2a t2a ADP american_scientific_journal-3226 56 31 t2b t2b PROPN american_scientific_journal-3226 56 32 t2c t2c PROPN american_scientific_journal-3226 56 33 t3a t3a PROPN american_scientific_journal-3226 56 34 t4 t4 PROPN american_scientific_journal-3226 56 35 70 70 NUM american_scientific_journal-3226 56 36 60 60 NUM american_scientific_journal-3226 56 37 - - SYM american_scientific_journal-3226 56 38 82 82 NUM american_scientific_journal-3226 56 39 12.15 12.15 NUM american_scientific_journal-3226 56 40 4.5 4.5 NUM american_scientific_journal-3226 56 41 - - SYM american_scientific_journal-3226 56 42 100 100 NUM american_scientific_journal-3226 56 43 13 13 NUM american_scientific_journal-3226 56 44 ( ( PUNCT american_scientific_journal-3226 56 45 46.4 46.4 NUM american_scientific_journal-3226 56 46 % % NOUN american_scientific_journal-3226 56 47 ) ) PUNCT american_scientific_journal-3226 56 48 2 2 NUM american_scientific_journal-3226 56 49 ( ( PUNCT american_scientific_journal-3226 56 50 7.1 7.1 NUM american_scientific_journal-3226 56 51 % % NOUN american_scientific_journal-3226 56 52 ) ) PUNCT american_scientific_journal-3226 56 53 5 5 NUM american_scientific_journal-3226 56 54 ( ( PUNCT american_scientific_journal-3226 56 55 55.6 55.6 NUM american_scientific_journal-3226 56 56 % % NOUN american_scientific_journal-3226 56 57 ) ) PUNCT american_scientific_journal-3226 56 58 5 5 NUM american_scientific_journal-3226 56 59 ( ( PUNCT american_scientific_journal-3226 56 60 17.9 17.9 NUM american_scientific_journal-3226 56 61 % % NOUN american_scientific_journal-3226 56 62 ) ) PUNCT american_scientific_journal-3226 56 63 0 0 NUM american_scientific_journal-3226 57 1 ( ( PUNCT american_scientific_journal-3226 57 2 0 0 NUM american_scientific_journal-3226 57 3 % % NOUN american_scientific_journal-3226 57 4 ) ) PUNCT american_scientific_journal-3226 57 5 3 3 NUM american_scientific_journal-3226 57 6 ( ( PUNCT american_scientific_journal-3226 57 7 10.7 10.7 NUM american_scientific_journal-3226 57 8 % % NOUN american_scientific_journal-3226 57 9 ) ) PUNCT american_scientific_journal-3226 58 1 67.5 67.5 NUM american_scientific_journal-3226 58 2 57 57 NUM american_scientific_journal-3226 58 3 - - SYM american_scientific_journal-3226 58 4 78 78 NUM american_scientific_journal-3226 58 5 12.05 12.05 NUM american_scientific_journal-3226 58 6 5.4 5.4 NUM american_scientific_journal-3226 58 7 - - SYM american_scientific_journal-3226 58 8 76.4 76.4 NUM american_scientific_journal-3226 58 9 6 6 NUM american_scientific_journal-3226 58 10 ( ( PUNCT american_scientific_journal-3226 58 11 50 50 NUM american_scientific_journal-3226 58 12 % % NOUN american_scientific_journal-3226 58 13 ) ) PUNCT american_scientific_journal-3226 58 14 1 1 NUM american_scientific_journal-3226 58 15 ( ( PUNCT american_scientific_journal-3226 58 16 8.3 8.3 NUM american_scientific_journal-3226 58 17 % % NOUN american_scientific_journal-3226 58 18 ) ) PUNCT american_scientific_journal-3226 58 19 4 4 NUM american_scientific_journal-3226 58 20 33.3 33.3 NUM american_scientific_journal-3226 58 21 % % NOUN american_scientific_journal-3226 58 22 ) ) PUNCT american_scientific_journal-3226 58 23 0 0 NUM american_scientific_journal-3226 59 1 ( ( PUNCT american_scientific_journal-3226 59 2 0 0 NUM american_scientific_journal-3226 59 3 % % NOUN american_scientific_journal-3226 59 4 ) ) PUNCT american_scientific_journal-3226 59 5 1 1 NUM american_scientific_journal-3226 59 6 ( ( PUNCT american_scientific_journal-3226 59 7 8.3 8.3 NUM american_scientific_journal-3226 59 8 % % NOUN american_scientific_journal-3226 59 9 ) ) PUNCT american_scientific_journal-3226 59 10 0 0 NUM american_scientific_journal-3226 60 1 ( ( PUNCT american_scientific_journal-3226 60 2 0 0 NUM american_scientific_journal-3226 60 3 % % NOUN american_scientific_journal-3226 60 4 ) ) PUNCT american_scientific_journal-3226 60 5 american american PROPN american_scientific_journal-3226 60 6 scientific scientific ADJ american_scientific_journal-3226 60 7 research research NOUN american_scientific_journal-3226 60 8 journal journal NOUN american_scientific_journal-3226 60 9 for for ADP american_scientific_journal-3226 60 10 engineering engineering NOUN american_scientific_journal-3226 60 11 , , PUNCT american_scientific_journal-3226 60 12 technology technology NOUN american_scientific_journal-3226 60 13 , , PUNCT american_scientific_journal-3226 60 14 and and CCONJ american_scientific_journal-3226 60 15 sciences science NOUN american_scientific_journal-3226 60 16 ( ( PUNCT american_scientific_journal-3226 60 17 asrjets asrjet NOUN american_scientific_journal-3226 60 18 ) ) PUNCT american_scientific_journal-3226 60 19 ( ( PUNCT american_scientific_journal-3226 60 20 2017 2017 NUM american_scientific_journal-3226 60 21 ) ) PUNCT american_scientific_journal-3226 60 22 volume volume NOUN american_scientific_journal-3226 60 23 35 35 NUM american_scientific_journal-3226 60 24 , , PUNCT american_scientific_journal-3226 60 25 no no DET american_scientific_journal-3226 60 26 1 1 NUM american_scientific_journal-3226 60 27 , , PUNCT american_scientific_journal-3226 60 28 pp pp ADV american_scientific_journal-3226 60 29 8 8 NUM american_scientific_journal-3226 60 30 - - SYM american_scientific_journal-3226 60 31 14 14 NUM american_scientific_journal-3226 60 32 11 11 NUM american_scientific_journal-3226 60 33 table table NOUN american_scientific_journal-3226 60 34 3 3 NUM american_scientific_journal-3226 60 35 : : PUNCT american_scientific_journal-3226 60 36 bivariate bivariate ADJ american_scientific_journal-3226 60 37 analysis analysis NOUN american_scientific_journal-3226 60 38 between between ADP american_scientific_journal-3226 60 39 mrna mrna PROPN american_scientific_journal-3226 60 40 p53 p53 NOUN american_scientific_journal-3226 60 41 and and CCONJ american_scientific_journal-3226 60 42 low low ADJ american_scientific_journal-3226 60 43 gs gs NOUN american_scientific_journal-3226 60 44 ( ( PUNCT american_scientific_journal-3226 60 45 2 2 NUM american_scientific_journal-3226 60 46 - - SYM american_scientific_journal-3226 60 47 6 6 NUM american_scientific_journal-3226 60 48 ) ) PUNCT american_scientific_journal-3226 60 49 and and CCONJ american_scientific_journal-3226 60 50 high high ADJ american_scientific_journal-3226 60 51 gs gs X american_scientific_journal-3226 60 52 ( ( PUNCT american_scientific_journal-3226 60 53 7 7 NUM american_scientific_journal-3226 60 54 - - SYM american_scientific_journal-3226 60 55 10 10 NUM american_scientific_journal-3226 60 56 ) ) PUNCT american_scientific_journal-3226 60 57 group group NOUN american_scientific_journal-3226 60 58 variable variable NOUN american_scientific_journal-3226 60 59 gs gs ADP american_scientific_journal-3226 60 60 2 2 NUM american_scientific_journal-3226 60 61 - - SYM american_scientific_journal-3226 60 62 6 6 NUM american_scientific_journal-3226 60 63 gs gs NOUN american_scientific_journal-3226 60 64 7 7 NUM american_scientific_journal-3226 60 65 - - SYM american_scientific_journal-3226 60 66 10 10 NUM american_scientific_journal-3226 60 67 p p NOUN american_scientific_journal-3226 60 68 value value NOUN american_scientific_journal-3226 60 69 n=28 n=28 PUNCT american_scientific_journal-3226 60 70 n=12 n=12 ADV american_scientific_journal-3226 60 71 mrna mrna PROPN american_scientific_journal-3226 60 72 p53 p53 PROPN american_scientific_journal-3226 60 73 243.52 243.52 NUM american_scientific_journal-3226 60 74 ± ± NUM american_scientific_journal-3226 60 75 490.52 490.52 NUM american_scientific_journal-3226 60 76 20.47 20.47 NUM american_scientific_journal-3226 60 77 ± ± NUM american_scientific_journal-3226 60 78 24.08 24.08 NUM american_scientific_journal-3226 60 79 < < X american_scientific_journal-3226 60 80 0.001 0.001 NUM american_scientific_journal-3226 60 81 * * PUNCT american_scientific_journal-3226 60 82 multivariate multivariate NOUN american_scientific_journal-3226 60 83 analysis analysis NOUN american_scientific_journal-3226 60 84 mrna mrna PROPN american_scientific_journal-3226 60 85 bcl-2 bcl-2 ADJ american_scientific_journal-3226 60 86 and and CCONJ american_scientific_journal-3226 60 87 mrnap53 mrnap53 NOUN american_scientific_journal-3226 60 88 result result NOUN american_scientific_journal-3226 60 89 only only ADV american_scientific_journal-3226 60 90 p53 p53 NOUN american_scientific_journal-3226 60 91 has have VERB american_scientific_journal-3226 60 92 significant significant ADJ american_scientific_journal-3226 60 93 correlation correlation NOUN american_scientific_journal-3226 60 94 to to ADP american_scientific_journal-3226 60 95 gleason gleason PROPN american_scientific_journal-3226 60 96 score score NOUN american_scientific_journal-3226 60 97 ( ( PUNCT american_scientific_journal-3226 60 98 p p NOUN american_scientific_journal-3226 60 99 value value NOUN american_scientific_journal-3226 60 100 < < X american_scientific_journal-3226 60 101 0,014 0,014 NUM american_scientific_journal-3226 60 102 ) ) PUNCT american_scientific_journal-3226 60 103 . . PUNCT american_scientific_journal-3226 61 1 table table NOUN american_scientific_journal-3226 61 2 4 4 NUM american_scientific_journal-3226 61 3 : : PUNCT american_scientific_journal-3226 61 4 multivariate multivariate VERB american_scientific_journal-3226 61 5 analysis analysis NOUN american_scientific_journal-3226 61 6 mrna mrna PROPN american_scientific_journal-3226 61 7 p53 p53 PROPN american_scientific_journal-3226 61 8 , , PUNCT american_scientific_journal-3226 61 9 bcl-2 bcl-2 PUNCT american_scientific_journal-3226 61 10 and and CCONJ american_scientific_journal-3226 61 11 gleason gleason PROPN american_scientific_journal-3226 61 12 score score PROPN american_scientific_journal-3226 61 13 b b PROPN american_scientific_journal-3226 61 14 s.e s.e PROPN american_scientific_journal-3226 61 15 . . PROPN american_scientific_journal-3226 61 16 wald wald PROPN american_scientific_journal-3226 61 17 df df PROPN american_scientific_journal-3226 61 18 sig sig PROPN american_scientific_journal-3226 61 19 . . PUNCT american_scientific_journal-3226 62 1 exp(b exp(b NUM american_scientific_journal-3226 62 2 ) ) PUNCT american_scientific_journal-3226 62 3 95 95 NUM american_scientific_journal-3226 62 4 % % NOUN american_scientific_journal-3226 62 5 c.i.for c.i.for PROPN american_scientific_journal-3226 62 6 exp(b exp(b PROPN american_scientific_journal-3226 62 7 ) ) PUNCT american_scientific_journal-3226 62 8 lower low ADJ american_scientific_journal-3226 62 9 upper upper ADJ american_scientific_journal-3226 62 10 step step NOUN american_scientific_journal-3226 62 11 1a 1a X american_scientific_journal-3226 62 12 age age NOUN american_scientific_journal-3226 62 13 -0.017 -0.017 ADP american_scientific_journal-3226 62 14 0.088 0.088 NUM american_scientific_journal-3226 62 15 0.037 0.037 NUM american_scientific_journal-3226 62 16 1 1 NUM american_scientific_journal-3226 62 17 0.847 0.847 NUM american_scientific_journal-3226 62 18 0.983 0.983 NUM american_scientific_journal-3226 62 19 0.828 0.828 NUM american_scientific_journal-3226 62 20 1.167 1.167 NUM american_scientific_journal-3226 62 21 mrnap53 mrnap53 NOUN american_scientific_journal-3226 62 22 -0.038 -0.038 PUNCT american_scientific_journal-3226 62 23 0.018 0.018 NUM american_scientific_journal-3226 62 24 4.214 4.214 NUM american_scientific_journal-3226 62 25 1 1 NUM american_scientific_journal-3226 62 26 0.040 0.040 NUM american_scientific_journal-3226 62 27 0.963 0.963 NUM american_scientific_journal-3226 62 28 0.929 0.929 NUM american_scientific_journal-3226 62 29 0.998 0.998 NUM american_scientific_journal-3226 62 30 mrnabcl2 mrnabcl2 NOUN american_scientific_journal-3226 62 31 -0.007 -0.007 NOUN american_scientific_journal-3226 62 32 0.008 0.008 NUM american_scientific_journal-3226 62 33 0.836 0.836 NUM american_scientific_journal-3226 62 34 1 1 NUM american_scientific_journal-3226 62 35 0.361 0.361 NUM american_scientific_journal-3226 62 36 0.993 0.993 NUM american_scientific_journal-3226 62 37 0.977 0.977 NUM american_scientific_journal-3226 62 38 1.008 1.008 NUM american_scientific_journal-3226 62 39 constant constant ADJ american_scientific_journal-3226 62 40 2.454 2.454 NUM american_scientific_journal-3226 62 41 5.970 5.970 NUM american_scientific_journal-3226 62 42 0.169 0.169 NUM american_scientific_journal-3226 62 43 1 1 NUM american_scientific_journal-3226 62 44 0.681 0.681 NUM american_scientific_journal-3226 62 45 11.631 11.631 NUM american_scientific_journal-3226 62 46 step step NOUN american_scientific_journal-3226 62 47 2a 2a NUM american_scientific_journal-3226 62 48 mrnap53 mrnap53 VERB american_scientific_journal-3226 62 49 -0.039 -0.039 PUNCT american_scientific_journal-3226 62 50 0.018 0.018 NUM american_scientific_journal-3226 62 51 4.697 4.697 NUM american_scientific_journal-3226 62 52 1 1 NUM american_scientific_journal-3226 62 53 0.030 0.030 NUM american_scientific_journal-3226 62 54 0.962 0.962 NUM american_scientific_journal-3226 62 55 0.929 0.929 NUM american_scientific_journal-3226 62 56 0.996 0.996 NUM american_scientific_journal-3226 62 57 mrnabcl2 mrnabcl2 NOUN american_scientific_journal-3226 62 58 -0.007 -0.007 PUNCT american_scientific_journal-3226 62 59 0.008 0.008 NUM american_scientific_journal-3226 62 60 0.807 0.807 NUM american_scientific_journal-3226 62 61 1 1 NUM american_scientific_journal-3226 62 62 0.369 0.369 NUM american_scientific_journal-3226 62 63 0.993 0.993 NUM american_scientific_journal-3226 62 64 0.977 0.977 NUM american_scientific_journal-3226 62 65 1.009 1.009 NUM american_scientific_journal-3226 62 66 constant constant ADJ american_scientific_journal-3226 62 67 1.310 1.310 NUM american_scientific_journal-3226 62 68 0.715 0.715 NUM american_scientific_journal-3226 62 69 3.354 3.354 NUM american_scientific_journal-3226 62 70 1 1 NUM american_scientific_journal-3226 62 71 0.067 0.067 NUM american_scientific_journal-3226 62 72 3.705 3.705 NUM american_scientific_journal-3226 62 73 step step NOUN american_scientific_journal-3226 62 74 3a 3a NUM american_scientific_journal-3226 62 75 mrnap53 mrnap53 VERB american_scientific_journal-3226 62 76 -0.043 -0.043 PUNCT american_scientific_journal-3226 62 77 0.017 0.017 NUM american_scientific_journal-3226 62 78 6.027 6.027 NUM american_scientific_journal-3226 62 79 1 1 NUM american_scientific_journal-3226 62 80 0.014 0.014 NUM american_scientific_journal-3226 62 81 0.958 0.958 NUM american_scientific_journal-3226 62 82 0.926 0.926 NUM american_scientific_journal-3226 62 83 0.991 0.991 NUM american_scientific_journal-3226 62 84 constant constant ADJ american_scientific_journal-3226 62 85 1.098 1.098 NUM american_scientific_journal-3226 62 86 0.651 0.651 NUM american_scientific_journal-3226 62 87 2.841 2.841 NUM american_scientific_journal-3226 62 88 1 1 NUM american_scientific_journal-3226 62 89 0.092 0.092 NUM american_scientific_journal-3226 62 90 2.997 2.997 NUM american_scientific_journal-3226 62 91 4 4 NUM american_scientific_journal-3226 62 92 . . PUNCT american_scientific_journal-3226 63 1 discussion discussion NOUN american_scientific_journal-3226 63 2 pca pca PROPN american_scientific_journal-3226 63 3 is be AUX american_scientific_journal-3226 63 4 one one NUM american_scientific_journal-3226 63 5 of of ADP american_scientific_journal-3226 63 6 the the DET american_scientific_journal-3226 63 7 malignancies malignancy NOUN american_scientific_journal-3226 63 8 with with ADP american_scientific_journal-3226 63 9 the the DET american_scientific_journal-3226 63 10 highest high ADJ american_scientific_journal-3226 63 11 frequency frequency NOUN american_scientific_journal-3226 63 12 of of ADP american_scientific_journal-3226 63 13 genetic genetic ADJ american_scientific_journal-3226 63 14 variations variation NOUN american_scientific_journal-3226 63 15 [ [ X american_scientific_journal-3226 63 16 19 19 NUM american_scientific_journal-3226 63 17 ] ] PUNCT american_scientific_journal-3226 63 18 . . PUNCT american_scientific_journal-3226 64 1 renan renan PROPN american_scientific_journal-3226 64 2 has have AUX american_scientific_journal-3226 64 3 calculated calculate VERB american_scientific_journal-3226 64 4 a a DET american_scientific_journal-3226 64 5 probability probability NOUN american_scientific_journal-3226 64 6 of of ADP american_scientific_journal-3226 64 7 12 12 NUM american_scientific_journal-3226 64 8 mutated mutate VERB american_scientific_journal-3226 64 9 genes gene NOUN american_scientific_journal-3226 64 10 from from ADP american_scientific_journal-3226 64 11 epidemiological epidemiological ADJ american_scientific_journal-3226 64 12 data datum NOUN american_scientific_journal-3226 64 13 [ [ X american_scientific_journal-3226 64 14 20 20 NUM american_scientific_journal-3226 64 15 ] ] PUNCT american_scientific_journal-3226 64 16 . . PUNCT american_scientific_journal-3226 65 1 it it PRON american_scientific_journal-3226 65 2 has have AUX american_scientific_journal-3226 65 3 been be AUX american_scientific_journal-3226 65 4 suggested suggest VERB american_scientific_journal-3226 65 5 that that SCONJ american_scientific_journal-3226 65 6 a a DET american_scientific_journal-3226 65 7 subset subset NOUN american_scientific_journal-3226 65 8 of of ADP american_scientific_journal-3226 65 9 mutant mutant ADJ american_scientific_journal-3226 65 10 alleles allele NOUN american_scientific_journal-3226 65 11 acquired acquire VERB american_scientific_journal-3226 65 12 by by ADP american_scientific_journal-3226 65 13 a a DET american_scientific_journal-3226 65 14 sub sub NOUN american_scientific_journal-3226 65 15 clone clone NOUN american_scientific_journal-3226 65 16 of of ADP american_scientific_journal-3226 65 17 tumor tumor NOUN american_scientific_journal-3226 65 18 cells cell NOUN american_scientific_journal-3226 65 19 early early ADV american_scientific_journal-3226 65 20 in in ADP american_scientific_journal-3226 65 21 tumorigenesis tumorigenesis NOUN american_scientific_journal-3226 65 22 leads lead VERB american_scientific_journal-3226 65 23 not not PART american_scientific_journal-3226 65 24 only only ADV american_scientific_journal-3226 65 25 to to ADP american_scientific_journal-3226 65 26 a a DET american_scientific_journal-3226 65 27 selected select VERB american_scientific_journal-3226 65 28 replication replication NOUN american_scientific_journal-3226 65 29 advantage advantage NOUN american_scientific_journal-3226 65 30 , , PUNCT american_scientific_journal-3226 65 31 but but CCONJ american_scientific_journal-3226 65 32 also also ADV american_scientific_journal-3226 65 33 , , PUNCT american_scientific_journal-3226 65 34 later later ADV american_scientific_journal-3226 65 35 in in ADP american_scientific_journal-3226 65 36 tumorigenesis tumorigenesis NOUN american_scientific_journal-3226 65 37 , , PUNCT american_scientific_journal-3226 65 38 to to ADP american_scientific_journal-3226 65 39 the the DET american_scientific_journal-3226 65 40 ability ability NOUN american_scientific_journal-3226 65 41 to to PART american_scientific_journal-3226 65 42 metastasize metastasize VERB american_scientific_journal-3226 65 43 [ [ PUNCT american_scientific_journal-3226 65 44 21 21 NUM american_scientific_journal-3226 65 45 ] ] PUNCT american_scientific_journal-3226 65 46 . . PUNCT american_scientific_journal-3226 66 1 clinical clinical ADJ american_scientific_journal-3226 66 2 tumor tumor NOUN american_scientific_journal-3226 66 3 stage stage NOUN american_scientific_journal-3226 66 4 , , PUNCT american_scientific_journal-3226 66 5 gleason gleason PROPN american_scientific_journal-3226 66 6 score score NOUN american_scientific_journal-3226 66 7 , , PUNCT american_scientific_journal-3226 66 8 and and CCONJ american_scientific_journal-3226 66 9 pretherapy pretherapy NOUN american_scientific_journal-3226 66 10 serum serum NOUN american_scientific_journal-3226 66 11 prostate prostate NOUN american_scientific_journal-3226 66 12 - - PUNCT american_scientific_journal-3226 66 13 specific specific ADJ american_scientific_journal-3226 66 14 antigen antigen NOUN american_scientific_journal-3226 66 15 ( ( PUNCT american_scientific_journal-3226 66 16 psa psa NOUN american_scientific_journal-3226 66 17 ) ) PUNCT american_scientific_journal-3226 66 18 in in ADP american_scientific_journal-3226 66 19 descending descend VERB american_scientific_journal-3226 66 20 order order NOUN american_scientific_journal-3226 66 21 were be AUX american_scientific_journal-3226 66 22 independently independently ADV american_scientific_journal-3226 66 23 associated associate VERB american_scientific_journal-3226 66 24 with with ADP american_scientific_journal-3226 66 25 clinical clinical ADJ american_scientific_journal-3226 66 26 or or CCONJ american_scientific_journal-3226 66 27 biochemical biochemical ADJ american_scientific_journal-3226 66 28 relapse relapse NOUN american_scientific_journal-3226 66 29 of of ADP american_scientific_journal-3226 66 30 pca pca PROPN american_scientific_journal-3226 66 31 [ [ X american_scientific_journal-3226 66 32 22 22 NUM american_scientific_journal-3226 66 33 ] ] PUNCT american_scientific_journal-3226 66 34 . . PUNCT american_scientific_journal-3226 67 1 mrna mrna PROPN american_scientific_journal-3226 67 2 p53 p53 NOUN american_scientific_journal-3226 67 3 expression expression NOUN american_scientific_journal-3226 67 4 is be AUX american_scientific_journal-3226 67 5 an an DET american_scientific_journal-3226 67 6 absolute absolute ADJ american_scientific_journal-3226 67 7 value value NOUN american_scientific_journal-3226 67 8 result result NOUN american_scientific_journal-3226 67 9 from from ADP american_scientific_journal-3226 67 10 transcription transcription NOUN american_scientific_journal-3226 67 11 promoter promoter NOUN american_scientific_journal-3226 67 12 gen gen PROPN american_scientific_journal-3226 67 13 p53 p53 NOUN american_scientific_journal-3226 67 14 . . PUNCT american_scientific_journal-3226 68 1 it it PRON american_scientific_journal-3226 68 2 has have AUX american_scientific_journal-3226 68 3 been be AUX american_scientific_journal-3226 68 4 suggested suggest VERB american_scientific_journal-3226 68 5 that that SCONJ american_scientific_journal-3226 68 6 a a DET american_scientific_journal-3226 68 7 subset subset NOUN american_scientific_journal-3226 68 8 of of ADP american_scientific_journal-3226 68 9 mutation mutation NOUN american_scientific_journal-3226 68 10 and and CCONJ american_scientific_journal-3226 68 11 the the DET american_scientific_journal-3226 68 12 protein protein NOUN american_scientific_journal-3226 68 13 caused cause VERB american_scientific_journal-3226 68 14 apoptosis apoptosis NOUN american_scientific_journal-3226 68 15 not not PART american_scientific_journal-3226 68 16 function function NOUN american_scientific_journal-3226 68 17 , , PUNCT american_scientific_journal-3226 68 18 cell cell NOUN american_scientific_journal-3226 68 19 survival survival NOUN american_scientific_journal-3226 68 20 and and CCONJ american_scientific_journal-3226 68 21 dna dna PROPN american_scientific_journal-3226 68 22 repaired repair VERB american_scientific_journal-3226 68 23 not not PART american_scientific_journal-3226 68 24 occurred occur VERB american_scientific_journal-3226 68 25 . . PUNCT american_scientific_journal-3226 69 1 the the DET american_scientific_journal-3226 69 2 cancer cancer NOUN american_scientific_journal-3226 69 3 cell cell NOUN american_scientific_journal-3226 69 4 become become VERB american_scientific_journal-3226 69 5 progressive progressive ADJ american_scientific_journal-3226 69 6 and and CCONJ american_scientific_journal-3226 69 7 prognosis prognosis NOUN american_scientific_journal-3226 69 8 is be AUX american_scientific_journal-3226 69 9 worse bad ADJ american_scientific_journal-3226 69 10 , , PUNCT american_scientific_journal-3226 69 11 cancer cancer NOUN american_scientific_journal-3226 69 12 undergo undergo VERB american_scientific_journal-3226 69 13 metastasis metastasis NOUN american_scientific_journal-3226 69 14 and and CCONJ american_scientific_journal-3226 69 15 castration castration NOUN american_scientific_journal-3226 69 16 resistant resistant ADJ american_scientific_journal-3226 69 17 . . PUNCT american_scientific_journal-3226 70 1 although although SCONJ american_scientific_journal-3226 70 2 not not PART american_scientific_journal-3226 70 3 only only ADV american_scientific_journal-3226 70 4 apoptosis apoptosis NOUN american_scientific_journal-3226 70 5 has have VERB american_scientific_journal-3226 70 6 a a DET american_scientific_journal-3226 70 7 role role NOUN american_scientific_journal-3226 70 8 , , PUNCT american_scientific_journal-3226 70 9 perhaps perhaps ADV american_scientific_journal-3226 70 10 there there PRON american_scientific_journal-3226 70 11 is be VERB american_scientific_journal-3226 70 12 multiple multiple ADJ american_scientific_journal-3226 70 13 mutation mutation NOUN american_scientific_journal-3226 70 14 follow follow VERB american_scientific_journal-3226 70 15 the the DET american_scientific_journal-3226 70 16 first first ADJ american_scientific_journal-3226 70 17 mutation mutation NOUN american_scientific_journal-3226 70 18 [ [ X american_scientific_journal-3226 70 19 23,24 23,24 ADP american_scientific_journal-3226 70 20 ] ] PUNCT american_scientific_journal-3226 70 21 . . PUNCT american_scientific_journal-3226 71 1 the the DET american_scientific_journal-3226 71 2 antiapoptotic antiapoptotic ADJ american_scientific_journal-3226 71 3 protein protein NOUN american_scientific_journal-3226 71 4 bcl-2 bcl-2 VERB american_scientific_journal-3226 71 5 is be AUX american_scientific_journal-3226 71 6 overexpressed overexpresse VERB american_scientific_journal-3226 71 7 in in ADP american_scientific_journal-3226 71 8 about about ADP american_scientific_journal-3226 71 9 american american ADJ american_scientific_journal-3226 71 10 scientific scientific ADJ american_scientific_journal-3226 71 11 research research NOUN american_scientific_journal-3226 71 12 journal journal NOUN american_scientific_journal-3226 71 13 for for ADP american_scientific_journal-3226 71 14 engineering engineering NOUN american_scientific_journal-3226 71 15 , , PUNCT american_scientific_journal-3226 71 16 technology technology NOUN american_scientific_journal-3226 71 17 , , PUNCT american_scientific_journal-3226 71 18 and and CCONJ american_scientific_journal-3226 71 19 sciences science NOUN american_scientific_journal-3226 71 20 ( ( PUNCT american_scientific_journal-3226 71 21 asrjets asrjet NOUN american_scientific_journal-3226 71 22 ) ) PUNCT american_scientific_journal-3226 71 23 ( ( PUNCT american_scientific_journal-3226 71 24 2017 2017 NUM american_scientific_journal-3226 71 25 ) ) PUNCT american_scientific_journal-3226 71 26 volume volume NOUN american_scientific_journal-3226 71 27 35 35 NUM american_scientific_journal-3226 71 28 , , PUNCT american_scientific_journal-3226 71 29 no no DET american_scientific_journal-3226 71 30 1 1 NUM american_scientific_journal-3226 71 31 , , PUNCT american_scientific_journal-3226 71 32 pp pp ADV american_scientific_journal-3226 71 33 8 8 NUM american_scientific_journal-3226 71 34 - - SYM american_scientific_journal-3226 71 35 14 14 NUM american_scientific_journal-3226 71 36 12 12 NUM american_scientific_journal-3226 71 37 half half NOUN american_scientific_journal-3226 71 38 of of ADP american_scientific_journal-3226 71 39 all all DET american_scientific_journal-3226 71 40 prostate prostate NOUN american_scientific_journal-3226 71 41 cancers cancer NOUN american_scientific_journal-3226 71 42 , , PUNCT american_scientific_journal-3226 71 43 particularly particularly ADV american_scientific_journal-3226 71 44 in in ADP american_scientific_journal-3226 71 45 androgen androgen NOUN american_scientific_journal-3226 71 46 - - PUNCT american_scientific_journal-3226 71 47 independent independent ADJ american_scientific_journal-3226 71 48 cases case NOUN american_scientific_journal-3226 71 49 [ [ X american_scientific_journal-3226 71 50 25 25 NUM american_scientific_journal-3226 71 51 ] ] PUNCT american_scientific_journal-3226 71 52 . . PUNCT american_scientific_journal-3226 72 1 second second ADJ american_scientific_journal-3226 72 2 factor factor NOUN american_scientific_journal-3226 72 3 in in ADP american_scientific_journal-3226 72 4 diminished diminished ADJ american_scientific_journal-3226 72 5 apoptosis apoptosis NOUN american_scientific_journal-3226 72 6 in in ADP american_scientific_journal-3226 72 7 prostate prostate NOUN american_scientific_journal-3226 72 8 cancers cancer NOUN american_scientific_journal-3226 72 9 is be AUX american_scientific_journal-3226 72 10 bcl-2 bcl-2 VERB american_scientific_journal-3226 72 11 . . PUNCT american_scientific_journal-3226 73 1 bcl-2 bcl-2 NOUN american_scientific_journal-3226 73 2 is be AUX american_scientific_journal-3226 73 3 not not PART american_scientific_journal-3226 73 4 expressed express VERB american_scientific_journal-3226 73 5 in in ADP american_scientific_journal-3226 73 6 normal normal ADJ american_scientific_journal-3226 73 7 secretory secretory ADJ american_scientific_journal-3226 73 8 epithelial epithelial ADJ american_scientific_journal-3226 73 9 cells cell NOUN american_scientific_journal-3226 73 10 of of ADP american_scientific_journal-3226 73 11 the the DET american_scientific_journal-3226 73 12 prostate prostate NOUN american_scientific_journal-3226 73 13 , , PUNCT american_scientific_journal-3226 73 14 but but CCONJ american_scientific_journal-3226 73 15 starting start VERB american_scientific_journal-3226 73 16 from from ADP american_scientific_journal-3226 73 17 pin pin NOUN american_scientific_journal-3226 73 18 , , PUNCT american_scientific_journal-3226 73 19 bcl-2 bcl-2 VERB american_scientific_journal-3226 73 20 is be AUX american_scientific_journal-3226 73 21 frequently frequently ADV american_scientific_journal-3226 73 22 expressed express VERB american_scientific_journal-3226 73 23 throughout throughout ADP american_scientific_journal-3226 73 24 the the DET american_scientific_journal-3226 73 25 epithelium epithelium NOUN american_scientific_journal-3226 74 1 [ [ X american_scientific_journal-3226 74 2 25 25 NUM american_scientific_journal-3226 74 3 ] ] PUNCT american_scientific_journal-3226 74 4 . . PUNCT american_scientific_journal-3226 75 1 interestingly interestingly ADV american_scientific_journal-3226 75 2 , , PUNCT american_scientific_journal-3226 75 3 in in ADP american_scientific_journal-3226 75 4 the the DET american_scientific_journal-3226 75 5 androgen androgen NOUN american_scientific_journal-3226 75 6 - - PUNCT american_scientific_journal-3226 75 7 dependent dependent ADJ american_scientific_journal-3226 75 8 lncap lncap NOUN american_scientific_journal-3226 75 9 prostate prostate NOUN american_scientific_journal-3226 75 10 carcinoma carcinoma NOUN american_scientific_journal-3226 75 11 cell cell NOUN american_scientific_journal-3226 75 12 line line NOUN american_scientific_journal-3226 75 13 bcl-2 bcl-2 PUNCT american_scientific_journal-3226 75 14 expression expression NOUN american_scientific_journal-3226 75 15 is be AUX american_scientific_journal-3226 75 16 androgen androgen NOUN american_scientific_journal-3226 75 17 - - PUNCT american_scientific_journal-3226 75 18 dependent dependent ADJ american_scientific_journal-3226 75 19 [ [ X american_scientific_journal-3226 75 20 26 26 NUM american_scientific_journal-3226 75 21 ] ] PUNCT american_scientific_journal-3226 75 22 . . PUNCT american_scientific_journal-3226 76 1 tp53 tp53 PROPN american_scientific_journal-3226 76 2 tumor tumor NOUN american_scientific_journal-3226 76 3 suppressor suppressor NOUN american_scientific_journal-3226 76 4 gene gene NOUN american_scientific_journal-3226 76 5 is be AUX american_scientific_journal-3226 76 6 one one NUM american_scientific_journal-3226 76 7 of of ADP american_scientific_journal-3226 76 8 the the DET american_scientific_journal-3226 76 9 most most ADV american_scientific_journal-3226 76 10 frequently frequently ADV american_scientific_journal-3226 76 11 mutated mutate VERB american_scientific_journal-3226 76 12 genes gene NOUN american_scientific_journal-3226 76 13 in in ADP american_scientific_journal-3226 76 14 human human ADJ american_scientific_journal-3226 76 15 malignancies malignancy NOUN american_scientific_journal-3226 76 16 [ [ X american_scientific_journal-3226 76 17 27 27 NUM american_scientific_journal-3226 76 18 ] ] PUNCT american_scientific_journal-3226 76 19 . . PUNCT american_scientific_journal-3226 77 1 however however ADV american_scientific_journal-3226 77 2 , , PUNCT american_scientific_journal-3226 77 3 the the DET american_scientific_journal-3226 77 4 mutation mutation NOUN american_scientific_journal-3226 77 5 frequency frequency NOUN american_scientific_journal-3226 77 6 of of ADP american_scientific_journal-3226 77 7 tp53 tp53 PROPN american_scientific_journal-3226 77 8 in in ADP american_scientific_journal-3226 77 9 pca pca PROPN american_scientific_journal-3226 77 10 has have VERB american_scientific_journal-3226 77 11 a a DET american_scientific_journal-3226 77 12 low low ADJ american_scientific_journal-3226 77 13 level level NOUN american_scientific_journal-3226 77 14 of of ADP american_scientific_journal-3226 77 15 about about ADV american_scientific_journal-3226 77 16 30 30 NUM american_scientific_journal-3226 77 17 % % NOUN american_scientific_journal-3226 77 18 [ [ X american_scientific_journal-3226 77 19 28 28 NUM american_scientific_journal-3226 77 20 ] ] PUNCT american_scientific_journal-3226 77 21 . . PUNCT american_scientific_journal-3226 78 1 furthermore furthermore ADV american_scientific_journal-3226 78 2 , , PUNCT american_scientific_journal-3226 78 3 the the DET american_scientific_journal-3226 78 4 tp53 tp53 PROPN american_scientific_journal-3226 78 5 mutation mutation NOUN american_scientific_journal-3226 78 6 frequency frequency NOUN american_scientific_journal-3226 78 7 in in ADP american_scientific_journal-3226 78 8 prostate prostate NOUN american_scientific_journal-3226 78 9 tumor tumor NOUN american_scientific_journal-3226 78 10 tissue tissue NOUN american_scientific_journal-3226 78 11 does do AUX american_scientific_journal-3226 78 12 not not PART american_scientific_journal-3226 78 13 show show VERB american_scientific_journal-3226 78 14 a a DET american_scientific_journal-3226 78 15 significant significant ADJ american_scientific_journal-3226 78 16 rising rise VERB american_scientific_journal-3226 78 17 level level NOUN american_scientific_journal-3226 78 18 in in ADP american_scientific_journal-3226 78 19 correlation correlation NOUN american_scientific_journal-3226 78 20 with with ADP american_scientific_journal-3226 78 21 rising rise VERB american_scientific_journal-3226 78 22 tumor tumor NOUN american_scientific_journal-3226 78 23 grading grading NOUN american_scientific_journal-3226 78 24 and and CCONJ american_scientific_journal-3226 78 25 staging staging NOUN american_scientific_journal-3226 78 26 , , PUNCT american_scientific_journal-3226 78 27 as as ADP american_scientific_journal-3226 78 28 for for ADP american_scientific_journal-3226 78 29 example example NOUN american_scientific_journal-3226 78 30 in in ADP american_scientific_journal-3226 78 31 bladder bladder NOUN american_scientific_journal-3226 78 32 cancer cancer NOUN american_scientific_journal-3226 78 33 . . PUNCT american_scientific_journal-3226 79 1 mutations mutation NOUN american_scientific_journal-3226 79 2 of of ADP american_scientific_journal-3226 79 3 tp53 tp53 PROPN american_scientific_journal-3226 79 4 influence influence VERB american_scientific_journal-3226 79 5 the the DET american_scientific_journal-3226 79 6 activation activation NOUN american_scientific_journal-3226 79 7 of of ADP american_scientific_journal-3226 79 8 cell cell NOUN american_scientific_journal-3226 79 9 proliferation proliferation NOUN american_scientific_journal-3226 79 10 and and CCONJ american_scientific_journal-3226 79 11 suppression suppression NOUN american_scientific_journal-3226 79 12 of of ADP american_scientific_journal-3226 79 13 dna dna PROPN american_scientific_journal-3226 79 14 repair repair NOUN american_scientific_journal-3226 79 15 , , PUNCT american_scientific_journal-3226 79 16 and and CCONJ american_scientific_journal-3226 79 17 apoptosis apoptosis NOUN american_scientific_journal-3226 79 18 [ [ X american_scientific_journal-3226 79 19 29 29 NUM american_scientific_journal-3226 79 20 ] ] PUNCT american_scientific_journal-3226 79 21 . . PUNCT american_scientific_journal-3226 80 1 therefore therefore ADV american_scientific_journal-3226 80 2 , , PUNCT american_scientific_journal-3226 80 3 an an DET american_scientific_journal-3226 80 4 acceleration acceleration NOUN american_scientific_journal-3226 80 5 of of ADP american_scientific_journal-3226 80 6 tumor tumor NOUN american_scientific_journal-3226 80 7 progression progression NOUN american_scientific_journal-3226 80 8 by by ADP american_scientific_journal-3226 80 9 tp53 tp53 PROPN american_scientific_journal-3226 80 10 mutations mutation NOUN american_scientific_journal-3226 80 11 was be AUX american_scientific_journal-3226 80 12 claimed claim VERB american_scientific_journal-3226 80 13 [ [ X american_scientific_journal-3226 80 14 30,31 30,31 NUM american_scientific_journal-3226 80 15 ] ] PUNCT american_scientific_journal-3226 80 16 . . PUNCT american_scientific_journal-3226 81 1 kuczyk kuczyk PROPN american_scientific_journal-3226 81 2 and and CCONJ american_scientific_journal-3226 81 3 his his PRON american_scientific_journal-3226 81 4 colleagues colleague NOUN american_scientific_journal-3226 81 5 have have AUX american_scientific_journal-3226 81 6 described describe VERB american_scientific_journal-3226 81 7 a a DET american_scientific_journal-3226 81 8 correlation correlation NOUN american_scientific_journal-3226 81 9 between between ADP american_scientific_journal-3226 81 10 overexpression overexpression NOUN american_scientific_journal-3226 81 11 of of ADP american_scientific_journal-3226 81 12 p53 p53 NOUN american_scientific_journal-3226 81 13 protein protein NOUN american_scientific_journal-3226 81 14 and and CCONJ american_scientific_journal-3226 81 15 tumor tumor NOUN american_scientific_journal-3226 81 16 progression progression NOUN american_scientific_journal-3226 81 17 in in ADP american_scientific_journal-3226 81 18 pca pca PROPN american_scientific_journal-3226 81 19 patients patient NOUN american_scientific_journal-3226 81 20 during during ADP american_scientific_journal-3226 81 21 univariate univariate ADJ american_scientific_journal-3226 81 22 analysis analysis NOUN american_scientific_journal-3226 81 23 . . PUNCT american_scientific_journal-3226 82 1 p53 p53 NOUN american_scientific_journal-3226 82 2 overexpression overexpression NOUN american_scientific_journal-3226 82 3 , , PUNCT american_scientific_journal-3226 82 4 histological histological ADJ american_scientific_journal-3226 82 5 grading grading NOUN american_scientific_journal-3226 82 6 , , PUNCT american_scientific_journal-3226 82 7 and and CCONJ american_scientific_journal-3226 82 8 tumor tumor NOUN american_scientific_journal-3226 82 9 stage stage NOUN american_scientific_journal-3226 82 10 were be AUX american_scientific_journal-3226 82 11 significant significant ADJ american_scientific_journal-3226 82 12 prognostic prognostic ADJ american_scientific_journal-3226 82 13 factors factor NOUN american_scientific_journal-3226 82 14 for for ADP american_scientific_journal-3226 82 15 survival survival NOUN american_scientific_journal-3226 82 16 , , PUNCT american_scientific_journal-3226 82 17 among among ADP american_scientific_journal-3226 82 18 which which PRON american_scientific_journal-3226 82 19 only only ADV american_scientific_journal-3226 82 20 p53 p53 NOUN american_scientific_journal-3226 82 21 overexpression overexpression NOUN american_scientific_journal-3226 82 22 remained remain VERB american_scientific_journal-3226 82 23 an an DET american_scientific_journal-3226 82 24 independent independent ADJ american_scientific_journal-3226 82 25 significant significant ADJ american_scientific_journal-3226 82 26 predictor predictor NOUN american_scientific_journal-3226 82 27 in in ADP american_scientific_journal-3226 82 28 multivariate multivariate NOUN american_scientific_journal-3226 82 29 analysis analysis NOUN american_scientific_journal-3226 82 30 [ [ X american_scientific_journal-3226 82 31 32 32 NUM american_scientific_journal-3226 82 32 ] ] PUNCT american_scientific_journal-3226 82 33 . . PUNCT american_scientific_journal-3226 83 1 in in ADP american_scientific_journal-3226 83 2 this this DET american_scientific_journal-3226 83 3 study study NOUN american_scientific_journal-3226 83 4 gen gen PROPN american_scientific_journal-3226 83 5 p53 p53 NOUN american_scientific_journal-3226 83 6 expression expression NOUN american_scientific_journal-3226 83 7 , , PUNCT american_scientific_journal-3226 83 8 histopathological histopathological ADJ american_scientific_journal-3226 83 9 gleason gleason PROPN american_scientific_journal-3226 83 10 score score NOUN american_scientific_journal-3226 83 11 during during ADP american_scientific_journal-3226 83 12 univariate univariate ADJ american_scientific_journal-3226 83 13 and and CCONJ american_scientific_journal-3226 83 14 multivariate multivariate VERB american_scientific_journal-3226 83 15 analysis analysis NOUN american_scientific_journal-3226 83 16 were be AUX american_scientific_journal-3226 83 17 significant significant ADJ american_scientific_journal-3226 83 18 correlated correlate VERB american_scientific_journal-3226 83 19 . . PUNCT american_scientific_journal-3226 84 1 5 5 X american_scientific_journal-3226 84 2 . . X american_scientific_journal-3226 84 3 limitations limitation NOUN american_scientific_journal-3226 84 4 although although SCONJ american_scientific_journal-3226 84 5 the the DET american_scientific_journal-3226 84 6 research research NOUN american_scientific_journal-3226 84 7 has have AUX american_scientific_journal-3226 84 8 reached reach VERB american_scientific_journal-3226 84 9 its its PRON american_scientific_journal-3226 84 10 aims aim NOUN american_scientific_journal-3226 84 11 , , PUNCT american_scientific_journal-3226 84 12 there there PRON american_scientific_journal-3226 84 13 were be VERB american_scientific_journal-3226 84 14 some some DET american_scientific_journal-3226 84 15 unavoidable unavoidable ADJ american_scientific_journal-3226 84 16 limitations limitation NOUN american_scientific_journal-3226 84 17 . . PUNCT american_scientific_journal-3226 85 1 first first ADV american_scientific_journal-3226 85 2 , , PUNCT american_scientific_journal-3226 85 3 because because SCONJ american_scientific_journal-3226 85 4 of of ADP american_scientific_journal-3226 85 5 the the DET american_scientific_journal-3226 85 6 time time NOUN american_scientific_journal-3226 85 7 limit limit NOUN american_scientific_journal-3226 85 8 , , PUNCT american_scientific_journal-3226 85 9 this this DET american_scientific_journal-3226 85 10 research research NOUN american_scientific_journal-3226 85 11 was be AUX american_scientific_journal-3226 85 12 conducted conduct VERB american_scientific_journal-3226 85 13 only only ADV american_scientific_journal-3226 85 14 on on ADP american_scientific_journal-3226 85 15 a a DET american_scientific_journal-3226 85 16 small small ADJ american_scientific_journal-3226 85 17 size size NOUN american_scientific_journal-3226 85 18 of of ADP american_scientific_journal-3226 85 19 population population NOUN american_scientific_journal-3226 85 20 who who PRON american_scientific_journal-3226 85 21 underwent undergo VERB american_scientific_journal-3226 85 22 turp turp NOUN american_scientific_journal-3226 85 23 surgery surgery NOUN american_scientific_journal-3226 85 24 . . PUNCT american_scientific_journal-3226 86 1 as as SCONJ american_scientific_journal-3226 86 2 mentioned mention VERB american_scientific_journal-3226 86 3 before before ADV american_scientific_journal-3226 86 4 , , PUNCT american_scientific_journal-3226 86 5 the the DET american_scientific_journal-3226 86 6 median median ADJ american_scientific_journal-3226 86 7 age age NOUN american_scientific_journal-3226 86 8 was be AUX american_scientific_journal-3226 86 9 70 70 NUM american_scientific_journal-3226 86 10 years year NOUN american_scientific_journal-3226 86 11 old old ADJ american_scientific_journal-3226 86 12 . . PUNCT american_scientific_journal-3226 87 1 and and CCONJ american_scientific_journal-3226 87 2 on on ADP american_scientific_journal-3226 87 3 that that DET american_scientific_journal-3226 87 4 age age NOUN american_scientific_journal-3226 87 5 , , PUNCT american_scientific_journal-3226 87 6 the the DET american_scientific_journal-3226 87 7 amount amount NOUN american_scientific_journal-3226 87 8 of of ADP american_scientific_journal-3226 87 9 patient patient NOUN american_scientific_journal-3226 87 10 who who PRON american_scientific_journal-3226 87 11 were be AUX american_scientific_journal-3226 87 12 medically medically ADV american_scientific_journal-3226 87 13 eligible eligible ADJ american_scientific_journal-3226 87 14 for for ADP american_scientific_journal-3226 87 15 the the DET american_scientific_journal-3226 87 16 turp turp NOUN american_scientific_journal-3226 87 17 operation operation NOUN american_scientific_journal-3226 87 18 was be AUX american_scientific_journal-3226 87 19 considerably considerably ADV american_scientific_journal-3226 87 20 low low ADJ american_scientific_journal-3226 87 21 . . PUNCT american_scientific_journal-3226 88 1 another another DET american_scientific_journal-3226 88 2 challenge challenge NOUN american_scientific_journal-3226 88 3 faced face VERB american_scientific_journal-3226 88 4 was be AUX american_scientific_journal-3226 88 5 the the DET american_scientific_journal-3226 88 6 level level NOUN american_scientific_journal-3226 88 7 of of ADP american_scientific_journal-3226 88 8 education education NOUN american_scientific_journal-3226 88 9 each each DET american_scientific_journal-3226 88 10 patient patient NOUN american_scientific_journal-3226 88 11 had have VERB american_scientific_journal-3226 88 12 . . PUNCT american_scientific_journal-3226 89 1 in in ADP american_scientific_journal-3226 89 2 terms term NOUN american_scientific_journal-3226 89 3 of of ADP american_scientific_journal-3226 89 4 understanding understanding NOUN american_scientific_journal-3226 89 5 , , PUNCT american_scientific_journal-3226 89 6 the the DET american_scientific_journal-3226 89 7 majority majority NOUN american_scientific_journal-3226 89 8 of of ADP american_scientific_journal-3226 89 9 our our PRON american_scientific_journal-3226 89 10 patients patient NOUN american_scientific_journal-3226 89 11 were be AUX american_scientific_journal-3226 89 12 below below ADP american_scientific_journal-3226 89 13 average average ADJ american_scientific_journal-3226 89 14 . . PUNCT american_scientific_journal-3226 90 1 therefore therefore ADV american_scientific_journal-3226 90 2 , , PUNCT american_scientific_journal-3226 90 3 their their PRON american_scientific_journal-3226 90 4 misguided misguided ADJ american_scientific_journal-3226 90 5 concern concern NOUN american_scientific_journal-3226 90 6 about about ADP american_scientific_journal-3226 90 7 patient patient NOUN american_scientific_journal-3226 90 8 ’s ’s PART american_scientific_journal-3226 90 9 safety safety NOUN american_scientific_journal-3226 90 10 discouraged discourage VERB american_scientific_journal-3226 90 11 our our PRON american_scientific_journal-3226 90 12 patients patient NOUN american_scientific_journal-3226 90 13 and and CCONJ american_scientific_journal-3226 90 14 their their PRON american_scientific_journal-3226 90 15 relatives relative NOUN american_scientific_journal-3226 90 16 to to PART american_scientific_journal-3226 90 17 be be AUX american_scientific_journal-3226 90 18 enlisted enlist VERB american_scientific_journal-3226 90 19 in in ADP american_scientific_journal-3226 90 20 the the DET american_scientific_journal-3226 90 21 experiment experiment NOUN american_scientific_journal-3226 90 22 . . PUNCT american_scientific_journal-3226 91 1 6 6 X american_scientific_journal-3226 91 2 . . X american_scientific_journal-3226 91 3 conclusion conclusion NOUN american_scientific_journal-3226 91 4 it it PRON american_scientific_journal-3226 91 5 was be AUX american_scientific_journal-3226 91 6 found find VERB american_scientific_journal-3226 91 7 that that SCONJ american_scientific_journal-3226 91 8 p53 p53 NOUN american_scientific_journal-3226 91 9 gene gene NOUN american_scientific_journal-3226 91 10 expression expression NOUN american_scientific_journal-3226 91 11 was be AUX american_scientific_journal-3226 91 12 significantly significantly ADV american_scientific_journal-3226 91 13 correlated correlate VERB american_scientific_journal-3226 91 14 with with ADP american_scientific_journal-3226 91 15 the the DET american_scientific_journal-3226 91 16 progression progression NOUN american_scientific_journal-3226 91 17 of of ADP american_scientific_journal-3226 91 18 prostate prostate NOUN american_scientific_journal-3226 91 19 cancer cancer NOUN american_scientific_journal-3226 91 20 . . PUNCT american_scientific_journal-3226 92 1 7 7 X american_scientific_journal-3226 92 2 . . X american_scientific_journal-3226 92 3 recommendation recommendation NOUN american_scientific_journal-3226 92 4 with with ADP american_scientific_journal-3226 92 5 that that DET american_scientific_journal-3226 92 6 result result NOUN american_scientific_journal-3226 92 7 , , PUNCT american_scientific_journal-3226 92 8 p53 p53 NOUN american_scientific_journal-3226 92 9 gene gene NOUN american_scientific_journal-3226 92 10 expression expression NOUN american_scientific_journal-3226 92 11 can can AUX american_scientific_journal-3226 92 12 be be AUX american_scientific_journal-3226 92 13 used use VERB american_scientific_journal-3226 92 14 as as ADP american_scientific_journal-3226 92 15 an an DET american_scientific_journal-3226 92 16 independent independent ADJ american_scientific_journal-3226 92 17 prognostic prognostic ADJ american_scientific_journal-3226 92 18 factor factor NOUN american_scientific_journal-3226 92 19 for for ADP american_scientific_journal-3226 92 20 prostate prostate NOUN american_scientific_journal-3226 92 21 cancer cancer NOUN american_scientific_journal-3226 92 22 . . PUNCT american_scientific_journal-3226 93 1 references reference NOUN american_scientific_journal-3226 93 2 [ [ X american_scientific_journal-3226 93 3 1 1 NUM american_scientific_journal-3226 93 4 ] ] PUNCT american_scientific_journal-3226 93 5 . . PUNCT american_scientific_journal-3226 94 1 b b X american_scientific_journal-3226 94 2 sihombing sihombing NOUN american_scientific_journal-3226 94 3 , , PUNCT american_scientific_journal-3226 94 4 jamaludin jamaludin PROPN american_scientific_journal-3226 94 5 , , PUNCT american_scientific_journal-3226 94 6 dh dh PROPN american_scientific_journal-3226 94 7 cong cong PROPN american_scientific_journal-3226 94 8 , , PUNCT american_scientific_journal-3226 94 9 s s VERB american_scientific_journal-3226 94 10 ibrahim ibrahim PROPN american_scientific_journal-3226 94 11 , , PUNCT american_scientific_journal-3226 94 12 s s PART american_scientific_journal-3226 94 13 syukur syukur NOUN american_scientific_journal-3226 94 14 . . PUNCT american_scientific_journal-3226 95 1 “ " PUNCT american_scientific_journal-3226 95 2 immunohistohemical immunohistohemical ADJ american_scientific_journal-3226 95 3 detection detection NOUN american_scientific_journal-3226 95 4 on on ADP american_scientific_journal-3226 95 5 p53 p53 NOUN american_scientific_journal-3226 95 6 protein protein NOUN american_scientific_journal-3226 95 7 as as ADP american_scientific_journal-3226 95 8 a a DET american_scientific_journal-3226 95 9 prognostic prognostic ADJ american_scientific_journal-3226 95 10 indicator indicator NOUN american_scientific_journal-3226 95 11 in in ADP american_scientific_journal-3226 95 12 prostate prostate NOUN american_scientific_journal-3226 95 13 carcinoma carcinoma NOUN american_scientific_journal-3226 95 14 . . PUNCT american_scientific_journal-3226 95 15 ” " PUNCT american_scientific_journal-3226 96 1 the the DET american_scientific_journal-3226 96 2 journal journal NOUN american_scientific_journal-3226 96 3 of of ADP american_scientific_journal-3226 96 4 chemical chemical NOUN american_scientific_journal-3226 96 5 and and CCONJ american_scientific_journal-3226 96 6 pharmaceutical pharmaceutical NOUN american_scientific_journal-3226 96 7 research research NOUN american_scientific_journal-3226 96 8 , , PUNCT american_scientific_journal-3226 96 9 vol vol NOUN american_scientific_journal-3226 96 10 . . PUNCT american_scientific_journal-3226 96 11 7(9 7(9 NUM american_scientific_journal-3226 96 12 ) ) PUNCT american_scientific_journal-3226 96 13 , , PUNCT american_scientific_journal-3226 96 14 pp pp ADP american_scientific_journal-3226 96 15 . . PUNCT american_scientific_journal-3226 96 16 10 10 NUM american_scientific_journal-3226 96 17 . . X american_scientific_journal-3226 96 18 2015 2015 NUM american_scientific_journal-3226 96 19 . . PUNCT american_scientific_journal-3226 97 1 [ [ X american_scientific_journal-3226 97 2 2 2 NUM american_scientific_journal-3226 97 3 ] ] PUNCT american_scientific_journal-3226 97 4 . . PUNCT american_scientific_journal-3226 98 1 c c PROPN american_scientific_journal-3226 98 2 caulin caulin PROPN american_scientific_journal-3226 98 3 , , PUNCT american_scientific_journal-3226 98 4 t t PROPN american_scientific_journal-3226 98 5 nguyen nguyen NOUN american_scientific_journal-3226 98 6 , , PUNCT american_scientific_journal-3226 98 7 ga ga PROPN american_scientific_journal-3226 98 8 lang lang PROPN american_scientific_journal-3226 98 9 , , PUNCT american_scientific_journal-3226 98 10 tm tm PROPN american_scientific_journal-3226 98 11 goepfert goepfert PROPN american_scientific_journal-3226 98 12 , , PUNCT american_scientific_journal-3226 98 13 br br PROPN american_scientific_journal-3226 98 14 brinkley brinkley PROPN american_scientific_journal-3226 98 15 , , PUNCT american_scientific_journal-3226 98 16 ww ww PROPN american_scientific_journal-3226 98 17 cai cai PROPN american_scientific_journal-3226 98 18 , , PUNCT american_scientific_journal-3226 98 19 g g PROPN american_scientific_journal-3226 98 20 lozano lozano PROPN american_scientific_journal-3226 98 21 , , PUNCT american_scientific_journal-3226 98 22 and and CCONJ american_scientific_journal-3226 98 23 dr dr PROPN american_scientific_journal-3226 98 24 roop roop PROPN american_scientific_journal-3226 98 25 . . PUNCT american_scientific_journal-3226 99 1 “ " PUNCT american_scientific_journal-3226 99 2 an an DET american_scientific_journal-3226 99 3 american american ADJ american_scientific_journal-3226 99 4 scientific scientific ADJ american_scientific_journal-3226 99 5 research research NOUN american_scientific_journal-3226 99 6 journal journal NOUN american_scientific_journal-3226 99 7 for for ADP american_scientific_journal-3226 99 8 engineering engineering NOUN american_scientific_journal-3226 99 9 , , PUNCT american_scientific_journal-3226 99 10 technology technology NOUN american_scientific_journal-3226 99 11 , , PUNCT american_scientific_journal-3226 99 12 and and CCONJ american_scientific_journal-3226 99 13 sciences science NOUN american_scientific_journal-3226 99 14 ( ( PUNCT american_scientific_journal-3226 99 15 asrjets asrjet NOUN american_scientific_journal-3226 99 16 ) ) PUNCT american_scientific_journal-3226 99 17 ( ( PUNCT american_scientific_journal-3226 99 18 2017 2017 NUM american_scientific_journal-3226 99 19 ) ) PUNCT american_scientific_journal-3226 99 20 volume volume NOUN american_scientific_journal-3226 99 21 35 35 NUM american_scientific_journal-3226 99 22 , , PUNCT american_scientific_journal-3226 99 23 no no DET american_scientific_journal-3226 99 24 1 1 NUM american_scientific_journal-3226 99 25 , , PUNCT american_scientific_journal-3226 99 26 pp pp ADV american_scientific_journal-3226 99 27 8 8 NUM american_scientific_journal-3226 99 28 - - SYM american_scientific_journal-3226 99 29 14 14 NUM american_scientific_journal-3226 99 30 13 13 NUM american_scientific_journal-3226 99 31 inducible inducible ADJ american_scientific_journal-3226 99 32 mouse mouse NOUN american_scientific_journal-3226 99 33 model model NOUN american_scientific_journal-3226 99 34 for for ADP american_scientific_journal-3226 99 35 skin skin NOUN american_scientific_journal-3226 99 36 cancer cancer NOUN american_scientific_journal-3226 99 37 reveals reveal VERB american_scientific_journal-3226 99 38 distinct distinct ADJ american_scientific_journal-3226 99 39 roles role NOUN american_scientific_journal-3226 99 40 for for ADP american_scientific_journal-3226 99 41 gainand gainand NOUN american_scientific_journal-3226 99 42 loss loss NOUN american_scientific_journal-3226 99 43 - - PUNCT american_scientific_journal-3226 99 44 of of ADP american_scientific_journal-3226 99 45 - - PUNCT american_scientific_journal-3226 99 46 function function NOUN american_scientific_journal-3226 99 47 p53 p53 NOUN american_scientific_journal-3226 99 48 mutations mutation NOUN american_scientific_journal-3226 99 49 . . PUNCT american_scientific_journal-3226 99 50 ” " PUNCT american_scientific_journal-3226 100 1 j j PROPN american_scientific_journal-3226 100 2 clin clin PROPN american_scientific_journal-3226 100 3 invest invest PROPN american_scientific_journal-3226 100 4 . . PUNCT american_scientific_journal-3226 101 1 vol vol NOUN american_scientific_journal-3226 101 2 . . PUNCT american_scientific_journal-3226 102 1 117(7 117(7 NUM american_scientific_journal-3226 102 2 ) ) PUNCT american_scientific_journal-3226 102 3 . . PUNCT american_scientific_journal-3226 103 1 pp.1893 pp.1893 PROPN american_scientific_journal-3226 103 2 - - PUNCT american_scientific_journal-3226 103 3 901 901 NUM american_scientific_journal-3226 103 4 . . PUNCT american_scientific_journal-3226 104 1 2007 2007 NUM american_scientific_journal-3226 104 2 . . PUNCT american_scientific_journal-3226 105 1 [ [ X american_scientific_journal-3226 105 2 3 3 NUM american_scientific_journal-3226 105 3 ] ] PUNCT american_scientific_journal-3226 105 4 . . PUNCT american_scientific_journal-3226 106 1 g g PROPN american_scientific_journal-3226 106 2 liu liu PROPN american_scientific_journal-3226 106 3 , , PUNCT american_scientific_journal-3226 106 4 tj tj PROPN american_scientific_journal-3226 106 5 mcdonnell mcdonnell PROPN american_scientific_journal-3226 106 6 , , PUNCT american_scientific_journal-3226 106 7 r r PROPN american_scientific_journal-3226 106 8 montes montes PROPN american_scientific_journal-3226 106 9 de de PROPN american_scientific_journal-3226 106 10 oca oca PROPN american_scientific_journal-3226 106 11 luna luna PROPN american_scientific_journal-3226 106 12 , , PUNCT american_scientific_journal-3226 106 13 m m PROPN american_scientific_journal-3226 106 14 kapoor kapoor PROPN american_scientific_journal-3226 106 15 , , PUNCT american_scientific_journal-3226 106 16 b b PROPN american_scientific_journal-3226 106 17 mims mims PROPN american_scientific_journal-3226 106 18 , , PUNCT american_scientific_journal-3226 106 19 ak ak PROPN american_scientific_journal-3226 106 20 el el PROPN american_scientific_journal-3226 106 21 - - PUNCT american_scientific_journal-3226 106 22 naggar naggar NOUN american_scientific_journal-3226 106 23 , , PUNCT american_scientific_journal-3226 106 24 and and CCONJ american_scientific_journal-3226 106 25 g g PROPN american_scientific_journal-3226 106 26 lozano lozano PROPN american_scientific_journal-3226 106 27 . . PUNCT american_scientific_journal-3226 107 1 “ " PUNCT american_scientific_journal-3226 107 2 high high ADJ american_scientific_journal-3226 107 3 metastatic metastatic ADJ american_scientific_journal-3226 107 4 potential potential NOUN american_scientific_journal-3226 107 5 in in ADP american_scientific_journal-3226 107 6 mice mouse NOUN american_scientific_journal-3226 107 7 inheriting inherit VERB american_scientific_journal-3226 107 8 a a DET american_scientific_journal-3226 107 9 targeted target VERB american_scientific_journal-3226 107 10 p53 p53 NOUN american_scientific_journal-3226 107 11 missense missense NOUN american_scientific_journal-3226 107 12 mutation mutation NOUN american_scientific_journal-3226 107 13 . . PUNCT american_scientific_journal-3226 107 14 ” " PUNCT american_scientific_journal-3226 108 1 proc proc PROPN american_scientific_journal-3226 108 2 natl natl PROPN american_scientific_journal-3226 108 3 acad acad PROPN american_scientific_journal-3226 108 4 sci sci PROPN american_scientific_journal-3226 108 5 usa usa PROPN american_scientific_journal-3226 108 6 , , PUNCT american_scientific_journal-3226 108 7 vol vol NOUN american_scientific_journal-3226 108 8 . . PROPN american_scientific_journal-3226 108 9 97 97 NUM american_scientific_journal-3226 108 10 , , PUNCT american_scientific_journal-3226 108 11 pp pp ADJ american_scientific_journal-3226 108 12 . . PUNCT american_scientific_journal-3226 108 13 41749 41749 NUM american_scientific_journal-3226 108 14 . . PUNCT american_scientific_journal-3226 109 1 2000 2000 NUM american_scientific_journal-3226 109 2 . . PUNCT american_scientific_journal-3226 110 1 [ [ X american_scientific_journal-3226 110 2 4 4 NUM american_scientific_journal-3226 110 3 ] ] PUNCT american_scientific_journal-3226 110 4 . . PUNCT american_scientific_journal-3226 111 1 m m PROPN american_scientific_journal-3226 111 2 seto seto NOUN american_scientific_journal-3226 111 3 , , PUNCT american_scientific_journal-3226 111 4 u u NOUN american_scientific_journal-3226 111 5 jaeger jaeger NOUN american_scientific_journal-3226 111 6 , , PUNCT american_scientific_journal-3226 111 7 rd rd PROPN american_scientific_journal-3226 111 8 hockett hockett PROPN american_scientific_journal-3226 111 9 , , PUNCT american_scientific_journal-3226 111 10 w w PROPN american_scientific_journal-3226 111 11 graninger graninger NOUN american_scientific_journal-3226 111 12 , , PUNCT american_scientific_journal-3226 111 13 s s PROPN american_scientific_journal-3226 111 14 bennett bennett PROPN american_scientific_journal-3226 111 15 , , PUNCT american_scientific_journal-3226 111 16 et et PROPN american_scientific_journal-3226 111 17 al al PROPN american_scientific_journal-3226 111 18 . . PUNCT american_scientific_journal-3226 112 1 “ " PUNCT american_scientific_journal-3226 112 2 alternative alternative ADJ american_scientific_journal-3226 112 3 promoters promoter NOUN american_scientific_journal-3226 112 4 and and CCONJ american_scientific_journal-3226 112 5 exons exon NOUN american_scientific_journal-3226 112 6 , , PUNCT american_scientific_journal-3226 112 7 somatic somatic ADJ american_scientific_journal-3226 112 8 mutation mutation NOUN american_scientific_journal-3226 112 9 and and CCONJ american_scientific_journal-3226 112 10 deregulation deregulation NOUN american_scientific_journal-3226 112 11 of of ADP american_scientific_journal-3226 112 12 the the DET american_scientific_journal-3226 112 13 bcl-2 bcl-2 VERB american_scientific_journal-3226 112 14 - - PUNCT american_scientific_journal-3226 112 15 ig ig PROPN american_scientific_journal-3226 112 16 fusion fusion NOUN american_scientific_journal-3226 112 17 gene gene NOUN american_scientific_journal-3226 112 18 in in ADP american_scientific_journal-3226 112 19 lymphoma lymphoma NOUN american_scientific_journal-3226 112 20 . . PUNCT american_scientific_journal-3226 112 21 ” " PUNCT american_scientific_journal-3226 113 1 the the DET american_scientific_journal-3226 113 2 embo embo PROPN american_scientific_journal-3226 113 3 journal journal PROPN american_scientific_journal-3226 113 4 , , PUNCT american_scientific_journal-3226 113 5 vol vol NOUN american_scientific_journal-3226 113 6 . . PROPN american_scientific_journal-3226 113 7 7 7 NUM american_scientific_journal-3226 113 8 , , PUNCT american_scientific_journal-3226 113 9 pp pp ADJ american_scientific_journal-3226 113 10 . . PUNCT american_scientific_journal-3226 113 11 123 123 NUM american_scientific_journal-3226 113 12 131 131 NUM american_scientific_journal-3226 113 13 . . PUNCT american_scientific_journal-3226 113 14 1988 1988 NUM american_scientific_journal-3226 113 15 . . PUNCT american_scientific_journal-3226 114 1 [ [ X american_scientific_journal-3226 114 2 5 5 NUM american_scientific_journal-3226 114 3 ] ] PUNCT american_scientific_journal-3226 114 4 . . PUNCT american_scientific_journal-3226 115 1 tj tj PROPN american_scientific_journal-3226 115 2 mcdonnell mcdonnell PROPN american_scientific_journal-3226 115 3 , , PUNCT american_scientific_journal-3226 115 4 nm nm ADJ american_scientific_journal-3226 115 5 navone navone NOUN american_scientific_journal-3226 115 6 , , PUNCT american_scientific_journal-3226 115 7 p p NOUN american_scientific_journal-3226 115 8 troncoso troncoso NOUN american_scientific_journal-3226 115 9 , , PUNCT american_scientific_journal-3226 115 10 et et PROPN american_scientific_journal-3226 115 11 al al PROPN american_scientific_journal-3226 115 12 . . PUNCT american_scientific_journal-3226 116 1 “ " PUNCT american_scientific_journal-3226 116 2 expression expression NOUN american_scientific_journal-3226 116 3 of of ADP american_scientific_journal-3226 116 4 bcl-2 bcl-2 PUNCT american_scientific_journal-3226 116 5 oncoprotein oncoprotein ADJ american_scientific_journal-3226 116 6 and and CCONJ american_scientific_journal-3226 116 7 p53 p53 NOUN american_scientific_journal-3226 116 8 protein protein NOUN american_scientific_journal-3226 116 9 accumulation accumulation NOUN american_scientific_journal-3226 116 10 in in ADP american_scientific_journal-3226 116 11 bone bone NOUN american_scientific_journal-3226 116 12 marrow marrow NOUN american_scientific_journal-3226 116 13 metastases metastasis NOUN american_scientific_journal-3226 116 14 of of ADP american_scientific_journal-3226 116 15 androgen androgen NOUN american_scientific_journal-3226 116 16 independent independent ADJ american_scientific_journal-3226 116 17 prostate prostate NOUN american_scientific_journal-3226 116 18 cancer cancer NOUN american_scientific_journal-3226 116 19 . . PUNCT american_scientific_journal-3226 116 20 ” " PUNCT american_scientific_journal-3226 117 1 j j PROPN american_scientific_journal-3226 117 2 urol urol PROPN american_scientific_journal-3226 117 3 . . PROPN american_scientific_journal-3226 117 4 , , PUNCT american_scientific_journal-3226 117 5 vol vol NOUN american_scientific_journal-3226 117 6 . . PUNCT american_scientific_journal-3226 117 7 157(2 157(2 NUM american_scientific_journal-3226 117 8 ) ) PUNCT american_scientific_journal-3226 117 9 , , PUNCT american_scientific_journal-3226 117 10 pp pp ADP american_scientific_journal-3226 117 11 . . PUNCT american_scientific_journal-3226 118 1 569 569 NUM american_scientific_journal-3226 118 2 - - SYM american_scientific_journal-3226 118 3 74 74 NUM american_scientific_journal-3226 118 4 . . PUNCT american_scientific_journal-3226 119 1 1997 1997 NUM american_scientific_journal-3226 119 2 . . PUNCT american_scientific_journal-3226 120 1 [ [ X american_scientific_journal-3226 120 2 6 6 NUM american_scientific_journal-3226 120 3 ] ] PUNCT american_scientific_journal-3226 120 4 . . PUNCT american_scientific_journal-3226 121 1 t t PROPN american_scientific_journal-3226 121 2 visakorpi visakorpi NOUN american_scientific_journal-3226 121 3 . . PUNCT american_scientific_journal-3226 122 1 “ " PUNCT american_scientific_journal-3226 122 2 proliferative proliferative ADJ american_scientific_journal-3226 122 3 activity activity NOUN american_scientific_journal-3226 122 4 determined determine VERB american_scientific_journal-3226 122 5 by by ADP american_scientific_journal-3226 122 6 dna dna PROPN american_scientific_journal-3226 122 7 flow flow NOUN american_scientific_journal-3226 122 8 cytometry cytometry NOUN american_scientific_journal-3226 122 9 and and CCONJ american_scientific_journal-3226 122 10 proliferating proliferate VERB american_scientific_journal-3226 122 11 cell cell NOUN american_scientific_journal-3226 122 12 nuclear nuclear ADJ american_scientific_journal-3226 122 13 antigen antigen NOUN american_scientific_journal-3226 122 14 ( ( PUNCT american_scientific_journal-3226 122 15 pcna pcna NOUN american_scientific_journal-3226 122 16 ) ) PUNCT american_scientific_journal-3226 122 17 immunohistochemistry immunohistochemistry NOUN american_scientific_journal-3226 122 18 as as ADP american_scientific_journal-3226 122 19 a a DET american_scientific_journal-3226 122 20 prognostic prognostic ADJ american_scientific_journal-3226 122 21 factor factor NOUN american_scientific_journal-3226 122 22 in in ADP american_scientific_journal-3226 122 23 prostatic prostatic ADJ american_scientific_journal-3226 122 24 carcinoma carcinoma NOUN american_scientific_journal-3226 122 25 . . PUNCT american_scientific_journal-3226 122 26 ” " PUNCT american_scientific_journal-3226 123 1 the the DET american_scientific_journal-3226 123 2 journal journal NOUN american_scientific_journal-3226 123 3 of of ADP american_scientific_journal-3226 123 4 pathology pathology PROPN american_scientific_journal-3226 123 5 , , PUNCT american_scientific_journal-3226 123 6 vol vol NOUN american_scientific_journal-3226 123 7 . . PUNCT american_scientific_journal-3226 123 8 168(1 168(1 NUM american_scientific_journal-3226 123 9 ) ) PUNCT american_scientific_journal-3226 123 10 , , PUNCT american_scientific_journal-3226 123 11 pp pp ADP american_scientific_journal-3226 123 12 . . PUNCT american_scientific_journal-3226 124 1 7 7 NUM american_scientific_journal-3226 124 2 - - SYM american_scientific_journal-3226 124 3 13.1992 13.1992 NUM american_scientific_journal-3226 124 4 . . PUNCT american_scientific_journal-3226 125 1 [ [ X american_scientific_journal-3226 125 2 7 7 NUM american_scientific_journal-3226 125 3 ] ] PUNCT american_scientific_journal-3226 125 4 . . PUNCT american_scientific_journal-3226 126 1 f f PROPN american_scientific_journal-3226 126 2 hofstädter hofstädter PROPN american_scientific_journal-3226 126 3 , , PUNCT american_scientific_journal-3226 126 4 r r NOUN american_scientific_journal-3226 126 5 knüchel knüchel PROPN american_scientific_journal-3226 126 6 , , PUNCT american_scientific_journal-3226 126 7 j j PROPN american_scientific_journal-3226 126 8 rüschoff rüschoff NOUN american_scientific_journal-3226 126 9 . . PUNCT american_scientific_journal-3226 127 1 “ " PUNCT american_scientific_journal-3226 127 2 cell cell NOUN american_scientific_journal-3226 127 3 proliferation proliferation NOUN american_scientific_journal-3226 127 4 assessment assessment NOUN american_scientific_journal-3226 127 5 in in ADP american_scientific_journal-3226 127 6 oncology oncology NOUN american_scientific_journal-3226 127 7 . . PUNCT american_scientific_journal-3226 127 8 ” " PUNCT american_scientific_journal-3226 128 1 virchows virchow NOUN american_scientific_journal-3226 128 2 arch arch VERB american_scientific_journal-3226 128 3 . . PUNCT american_scientific_journal-3226 129 1 , , PUNCT american_scientific_journal-3226 129 2 vol vol NOUN american_scientific_journal-3226 129 3 . . PUNCT american_scientific_journal-3226 130 1 427(3 427(3 NUM american_scientific_journal-3226 130 2 ) ) PUNCT american_scientific_journal-3226 130 3 , , PUNCT american_scientific_journal-3226 131 1 pp pp ADP american_scientific_journal-3226 131 2 . . PUNCT american_scientific_journal-3226 132 1 323 323 NUM american_scientific_journal-3226 132 2 - - SYM american_scientific_journal-3226 132 3 41 41 NUM american_scientific_journal-3226 132 4 . . PUNCT american_scientific_journal-3226 133 1 1995 1995 NUM american_scientific_journal-3226 133 2 . . PUNCT american_scientific_journal-3226 134 1 [ [ X american_scientific_journal-3226 134 2 8 8 NUM american_scientific_journal-3226 134 3 ] ] PUNCT american_scientific_journal-3226 134 4 . . PUNCT american_scientific_journal-3226 135 1 df df PROPN american_scientific_journal-3226 135 2 gleason gleason PROPN american_scientific_journal-3226 135 3 . . PUNCT american_scientific_journal-3226 136 1 “ " PUNCT american_scientific_journal-3226 136 2 classification classification NOUN american_scientific_journal-3226 136 3 of of ADP american_scientific_journal-3226 136 4 prostatic prostatic ADJ american_scientific_journal-3226 136 5 carcinomas carcinoma NOUN american_scientific_journal-3226 136 6 . . PUNCT american_scientific_journal-3226 136 7 ” " PUNCT american_scientific_journal-3226 137 1 cancer cancer PROPN american_scientific_journal-3226 137 2 chemother chemother PROPN american_scientific_journal-3226 137 3 rep rep PROPN american_scientific_journal-3226 137 4 , , PUNCT american_scientific_journal-3226 137 5 vol vol NOUN american_scientific_journal-3226 137 6 . . PUNCT american_scientific_journal-3226 137 7 50(3 50(3 NOUN american_scientific_journal-3226 137 8 ) ) PUNCT american_scientific_journal-3226 137 9 , , PUNCT american_scientific_journal-3226 137 10 pp pp PROPN american_scientific_journal-3226 137 11 . . PUNCT american_scientific_journal-3226 138 1 125 125 NUM american_scientific_journal-3226 138 2 - - SYM american_scientific_journal-3226 138 3 8 8 NUM american_scientific_journal-3226 138 4 . . NUM american_scientific_journal-3226 138 5 1996 1996 NUM american_scientific_journal-3226 138 6 . . PUNCT american_scientific_journal-3226 139 1 [ [ X american_scientific_journal-3226 139 2 9 9 NUM american_scientific_journal-3226 139 3 ] ] PUNCT american_scientific_journal-3226 139 4 . . PUNCT american_scientific_journal-3226 140 1 df df PROPN american_scientific_journal-3226 140 2 gleason gleason PROPN american_scientific_journal-3226 140 3 , , PUNCT american_scientific_journal-3226 140 4 gt gt PROPN american_scientific_journal-3226 140 5 mellinger mellinger NOUN american_scientific_journal-3226 140 6 . . PUNCT american_scientific_journal-3226 141 1 “ " PUNCT american_scientific_journal-3226 141 2 prediction prediction NOUN american_scientific_journal-3226 141 3 of of ADP american_scientific_journal-3226 141 4 prognosis prognosis NOUN american_scientific_journal-3226 141 5 for for ADP american_scientific_journal-3226 141 6 prostatic prostatic ADJ american_scientific_journal-3226 141 7 adenocarcinoma adenocarcinoma NOUN american_scientific_journal-3226 141 8 by by ADP american_scientific_journal-3226 141 9 combined combine VERB american_scientific_journal-3226 141 10 histological histological ADJ american_scientific_journal-3226 141 11 grading grading NOUN american_scientific_journal-3226 141 12 and and CCONJ american_scientific_journal-3226 141 13 clinical clinical ADJ american_scientific_journal-3226 141 14 staging staging NOUN american_scientific_journal-3226 141 15 . . PUNCT american_scientific_journal-3226 141 16 ” " PUNCT american_scientific_journal-3226 142 1 j j PROPN american_scientific_journal-3226 142 2 urol urol PROPN american_scientific_journal-3226 142 3 , , PUNCT american_scientific_journal-3226 142 4 vol vol NOUN american_scientific_journal-3226 142 5 . . NOUN american_scientific_journal-3226 142 6 111(1 111(1 NUM american_scientific_journal-3226 142 7 ) ) PUNCT american_scientific_journal-3226 142 8 , , PUNCT american_scientific_journal-3226 142 9 pp pp ADJ american_scientific_journal-3226 142 10 . . PUNCT american_scientific_journal-3226 143 1 58 58 NUM american_scientific_journal-3226 143 2 - - SYM american_scientific_journal-3226 143 3 64 64 NUM american_scientific_journal-3226 143 4 . . PUNCT american_scientific_journal-3226 144 1 1974 1974 NUM american_scientific_journal-3226 144 2 . . PUNCT american_scientific_journal-3226 145 1 [ [ X american_scientific_journal-3226 145 2 10 10 NUM american_scientific_journal-3226 145 3 ] ] PUNCT american_scientific_journal-3226 145 4 . . PUNCT american_scientific_journal-3226 145 5 t t PROPN american_scientific_journal-3226 145 6 gevaert gevaert PROPN american_scientific_journal-3226 145 7 . . PUNCT american_scientific_journal-3226 146 1 belgian belgian ADJ american_scientific_journal-3226 146 2 journal journal PROPN american_scientific_journal-3226 146 3 of of ADP american_scientific_journal-3226 146 4 medical medical ADJ american_scientific_journal-3226 146 5 oncolog oncolog NOUN american_scientific_journal-3226 146 6 , , PUNCT american_scientific_journal-3226 146 7 . . PUNCT american_scientific_journal-3226 147 1 vol vol NOUN american_scientific_journal-3226 147 2 . . PUNCT american_scientific_journal-3226 147 3 6(2 6(2 NUM american_scientific_journal-3226 147 4 ) ) PUNCT american_scientific_journal-3226 147 5 . . PUNCT american_scientific_journal-3226 148 1 2012 2012 NUM american_scientific_journal-3226 148 2 . . PUNCT american_scientific_journal-3226 149 1 [ [ X american_scientific_journal-3226 149 2 11 11 NUM american_scientific_journal-3226 149 3 ] ] PUNCT american_scientific_journal-3226 149 4 . . PUNCT american_scientific_journal-3226 150 1 s s PART american_scientific_journal-3226 150 2 syukur syukur NOUN american_scientific_journal-3226 150 3 , , PUNCT american_scientific_journal-3226 150 4 syafrizayanti syafrizayanti NOUN american_scientific_journal-3226 150 5 , , PUNCT american_scientific_journal-3226 150 6 s s PART american_scientific_journal-3226 150 7 zulaiha zulaiha NOUN american_scientific_journal-3226 150 8 . . PUNCT american_scientific_journal-3226 151 1 “ " PUNCT american_scientific_journal-3226 151 2 virgin virgin ADJ american_scientific_journal-3226 151 3 coconut coconut NOUN american_scientific_journal-3226 151 4 oil oil NOUN american_scientific_journal-3226 151 5 increase increase NOUN american_scientific_journal-3226 151 6 hdl hdl PROPN american_scientific_journal-3226 151 7 , , PUNCT american_scientific_journal-3226 151 8 lower low ADJ american_scientific_journal-3226 151 9 triglyceride triglyceride ADV american_scientific_journal-3226 151 10 and and CCONJ american_scientific_journal-3226 151 11 fatty fatty ADJ american_scientific_journal-3226 151 12 acids acid NOUN american_scientific_journal-3226 151 13 profile profile NOUN american_scientific_journal-3226 151 14 in in ADP american_scientific_journal-3226 151 15 blood blood NOUN american_scientific_journal-3226 151 16 serum serum NOUN american_scientific_journal-3226 151 17 of of ADP american_scientific_journal-3226 151 18 mus mus PROPN american_scientific_journal-3226 151 19 musculus musculus PROPN american_scientific_journal-3226 151 20 . . PUNCT american_scientific_journal-3226 151 21 ” " PUNCT american_scientific_journal-3226 152 1 the the DET american_scientific_journal-3226 152 2 research research NOUN american_scientific_journal-3226 152 3 journal journal PROPN american_scientific_journal-3226 152 4 of of ADP american_scientific_journal-3226 152 5 chemical chemical NOUN american_scientific_journal-3226 152 6 and and CCONJ american_scientific_journal-3226 152 7 pharmaceutical pharmaceutical NOUN american_scientific_journal-3226 152 8 , , PUNCT american_scientific_journal-3226 152 9 vol vol NOUN american_scientific_journal-3226 152 10 . . PROPN american_scientific_journal-3226 152 11 8(2 8(2 NUM american_scientific_journal-3226 152 12 ) ) PUNCT american_scientific_journal-3226 152 13 , , PUNCT american_scientific_journal-3226 152 14 pp pp ADP american_scientific_journal-3226 152 15 . . PUNCT american_scientific_journal-3226 152 16 1077 1077 NUM american_scientific_journal-3226 152 17 . . PUNCT american_scientific_journal-3226 152 18 2017 2017 NUM american_scientific_journal-3226 152 19 . . PUNCT american_scientific_journal-3226 153 1 [ [ X american_scientific_journal-3226 153 2 12 12 NUM american_scientific_journal-3226 153 3 ] ] PUNCT american_scientific_journal-3226 153 4 . . PUNCT american_scientific_journal-3226 154 1 hd hd PROPN american_scientific_journal-3226 154 2 van van PROPN american_scientific_journal-3226 154 3 guilder guilder NOUN american_scientific_journal-3226 154 4 , , PUNCT american_scientific_journal-3226 154 5 ke ke PROPN american_scientific_journal-3226 154 6 vrana vrana PROPN american_scientific_journal-3226 154 7 , , PUNCT american_scientific_journal-3226 154 8 wm wm PROPN american_scientific_journal-3226 154 9 freeman freeman PROPN american_scientific_journal-3226 154 10 . . PUNCT american_scientific_journal-3226 155 1 “ " PUNCT american_scientific_journal-3226 155 2 twenty twenty NUM american_scientific_journal-3226 155 3 - - PUNCT american_scientific_journal-3226 155 4 five five NUM american_scientific_journal-3226 155 5 years year NOUN american_scientific_journal-3226 155 6 of of ADP american_scientific_journal-3226 155 7 quantitative quantitative ADJ american_scientific_journal-3226 155 8 pcr pcr NOUN american_scientific_journal-3226 155 9 for for ADP american_scientific_journal-3226 155 10 gene gene NOUN american_scientific_journal-3226 155 11 expression expression NOUN american_scientific_journal-3226 155 12 analysis analysis NOUN american_scientific_journal-3226 155 13 . . PUNCT american_scientific_journal-3226 155 14 ” " PUNCT american_scientific_journal-3226 156 1 biotechniques biotechnique NOUN american_scientific_journal-3226 156 2 , , PUNCT american_scientific_journal-3226 156 3 vol vol NOUN american_scientific_journal-3226 156 4 . . PUNCT american_scientific_journal-3226 157 1 44(5 44(5 NUM american_scientific_journal-3226 157 2 ) ) PUNCT american_scientific_journal-3226 157 3 , , PUNCT american_scientific_journal-3226 158 1 pp pp ADP american_scientific_journal-3226 158 2 . . PUNCT american_scientific_journal-3226 159 1 619 619 NUM american_scientific_journal-3226 159 2 – – PUNCT american_scientific_journal-3226 159 3 626 626 NUM american_scientific_journal-3226 159 4 .2008 .2008 NOUN american_scientific_journal-3226 159 5 . . PUNCT american_scientific_journal-3226 160 1 [ [ X american_scientific_journal-3226 160 2 13 13 NUM american_scientific_journal-3226 160 3 ] ] PUNCT american_scientific_journal-3226 160 4 . . PUNCT american_scientific_journal-3226 160 5 hl hl PROPN american_scientific_journal-3226 160 6 tobing tobing PROPN american_scientific_journal-3226 160 7 , , PUNCT american_scientific_journal-3226 160 8 s s PART american_scientific_journal-3226 160 9 syukur syukur NOUN american_scientific_journal-3226 160 10 , , PUNCT american_scientific_journal-3226 160 11 e e NOUN american_scientific_journal-3226 160 12 purwati purwati NOUN american_scientific_journal-3226 160 13 , , PUNCT american_scientific_journal-3226 160 14 r r NOUN american_scientific_journal-3226 160 15 zein zein NOUN american_scientific_journal-3226 160 16 , , PUNCT american_scientific_journal-3226 160 17 r r NOUN american_scientific_journal-3226 160 18 muzahar muzahar NOUN american_scientific_journal-3226 160 19 , , PUNCT american_scientific_journal-3226 160 20 et et PROPN american_scientific_journal-3226 160 21 al al PROPN american_scientific_journal-3226 160 22 . . PUNCT american_scientific_journal-3226 161 1 “ " PUNCT american_scientific_journal-3226 161 2 comparison comparison NOUN american_scientific_journal-3226 161 3 of of ADP american_scientific_journal-3226 161 4 sd sd NOUN american_scientific_journal-3226 161 5 bio bio PROPN american_scientific_journal-3226 161 6 line line PROPN american_scientific_journal-3226 161 7 malaria malaria PROPN american_scientific_journal-3226 161 8 agpf agpf PROPN american_scientific_journal-3226 161 9 / / SYM american_scientific_journal-3226 161 10 pan pan NOUN american_scientific_journal-3226 161 11 test test NOUN american_scientific_journal-3226 161 12 with with ADP american_scientific_journal-3226 161 13 microscopic microscopic ADJ american_scientific_journal-3226 161 14 examination examination NOUN american_scientific_journal-3226 161 15 for for ADP american_scientific_journal-3226 161 16 detection detection NOUN american_scientific_journal-3226 161 17 of of ADP american_scientific_journal-3226 161 18 p.falciparum p.falciparum NOUN american_scientific_journal-3226 161 19 , , PUNCT american_scientific_journal-3226 161 20 p.vivax p.vivax PUNCT american_scientific_journal-3226 161 21 and and CCONJ american_scientific_journal-3226 161 22 mixed mixed ADJ american_scientific_journal-3226 161 23 infection infection NOUN american_scientific_journal-3226 161 24 in in ADP american_scientific_journal-3226 161 25 south south PROPN american_scientific_journal-3226 161 26 nias nias PROPN american_scientific_journal-3226 161 27 , , PUNCT american_scientific_journal-3226 161 28 north north NOUN american_scientific_journal-3226 161 29 sumatera sumatera PROPN american_scientific_journal-3226 161 30 , , PUNCT american_scientific_journal-3226 161 31 indonesia indonesia PROPN american_scientific_journal-3226 161 32 . . PUNCT american_scientific_journal-3226 161 33 ” " PUNCT american_scientific_journal-3226 162 1 the the DET american_scientific_journal-3226 162 2 research research NOUN american_scientific_journal-3226 162 3 journal journal NOUN american_scientific_journal-3226 162 4 of of ADP american_scientific_journal-3226 162 5 pharmaceutical pharmaceutical NOUN american_scientific_journal-3226 162 6 , , PUNCT american_scientific_journal-3226 162 7 biological biological ADJ american_scientific_journal-3226 162 8 and and CCONJ american_scientific_journal-3226 162 9 chemical chemical NOUN american_scientific_journal-3226 162 10 sciences science NOUN american_scientific_journal-3226 162 11 , , PUNCT american_scientific_journal-3226 162 12 vol vol NOUN american_scientific_journal-3226 162 13 . . PROPN american_scientific_journal-3226 162 14 6 6 NUM american_scientific_journal-3226 162 15 ( ( PUNCT american_scientific_journal-3226 162 16 3 3 NUM american_scientific_journal-3226 162 17 ) ) PUNCT american_scientific_journal-3226 162 18 , , PUNCT american_scientific_journal-3226 162 19 pp pp ADJ american_scientific_journal-3226 162 20 . . PUNCT american_scientific_journal-3226 162 21 917 917 NUM american_scientific_journal-3226 162 22 . . NOUN american_scientific_journal-3226 162 23 2015 2015 NUM american_scientific_journal-3226 162 24 . . PUNCT american_scientific_journal-3226 163 1 [ [ X american_scientific_journal-3226 163 2 14 14 NUM american_scientific_journal-3226 163 3 ] ] PUNCT american_scientific_journal-3226 163 4 . . PUNCT american_scientific_journal-3226 164 1 a a DET american_scientific_journal-3226 164 2 chetcuti chetcuti PROPN american_scientific_journal-3226 164 3 , , PUNCT american_scientific_journal-3226 164 4 s s NOUN american_scientific_journal-3226 164 5 margan margan NOUN american_scientific_journal-3226 164 6 , , PUNCT american_scientific_journal-3226 164 7 s s NOUN american_scientific_journal-3226 164 8 mann mann PROPN american_scientific_journal-3226 164 9 , , PUNCT american_scientific_journal-3226 164 10 p p PROPN american_scientific_journal-3226 164 11 russell russell PROPN american_scientific_journal-3226 164 12 , , PUNCT american_scientific_journal-3226 164 13 d d PROPN american_scientific_journal-3226 164 14 handelsman handelsman NOUN american_scientific_journal-3226 164 15 , , PUNCT american_scientific_journal-3226 164 16 j j PROPN american_scientific_journal-3226 164 17 rogers rogers PROPN american_scientific_journal-3226 164 18 , , PUNCT american_scientific_journal-3226 164 19 q q PROPN american_scientific_journal-3226 164 20 dong dong PROPN american_scientific_journal-3226 164 21 . . PUNCT american_scientific_journal-3226 165 1 identification identification NOUN american_scientific_journal-3226 165 2 of of ADP american_scientific_journal-3226 165 3 differentially differentially ADV american_scientific_journal-3226 165 4 expressed express VERB american_scientific_journal-3226 165 5 genes gene NOUN american_scientific_journal-3226 165 6 in in ADP american_scientific_journal-3226 165 7 organ organ NOUN american_scientific_journal-3226 165 8 - - PUNCT american_scientific_journal-3226 165 9 confined confine VERB american_scientific_journal-3226 165 10 prostate prostate NOUN american_scientific_journal-3226 165 11 cancer cancer NOUN american_scientific_journal-3226 165 12 by by ADP american_scientific_journal-3226 165 13 gene gene NOUN american_scientific_journal-3226 165 14 expression expression NOUN american_scientific_journal-3226 165 15 array array NOUN american_scientific_journal-3226 165 16 . . PUNCT american_scientific_journal-3226 166 1 prostate prostate NOUN american_scientific_journal-3226 166 2 , , PUNCT american_scientific_journal-3226 166 3 vol vol NOUN american_scientific_journal-3226 166 4 . . PUNCT american_scientific_journal-3226 166 5 47(2 47(2 PROPN american_scientific_journal-3226 166 6 ) ) PUNCT american_scientific_journal-3226 166 7 , , PUNCT american_scientific_journal-3226 166 8 pp pp ADP american_scientific_journal-3226 166 9 . . PUNCT american_scientific_journal-3226 167 1 132–40 132–40 NUM american_scientific_journal-3226 167 2 . . PUNCT american_scientific_journal-3226 168 1 2001 2001 NUM american_scientific_journal-3226 168 2 . . PUNCT american_scientific_journal-3226 169 1 [ [ X american_scientific_journal-3226 169 2 15 15 NUM american_scientific_journal-3226 169 3 ] ] PUNCT american_scientific_journal-3226 169 4 . . PUNCT american_scientific_journal-3226 170 1 y y PROPN american_scientific_journal-3226 170 2 ding ding PROPN american_scientific_journal-3226 170 3 , , PUNCT american_scientific_journal-3226 170 4 l l PROPN american_scientific_journal-3226 170 5 xu xu PROPN american_scientific_journal-3226 170 6 , , PUNCT american_scientific_journal-3226 170 7 s s PART american_scientific_journal-3226 170 8 chen chen PROPN american_scientific_journal-3226 170 9 , , PUNCT american_scientific_journal-3226 170 10 bd bd PROPN american_scientific_journal-3226 170 11 jovanovic jovanovic PROPN american_scientific_journal-3226 170 12 , , PUNCT american_scientific_journal-3226 170 13 ib ib PROPN american_scientific_journal-3226 170 14 helenowski helenowski PROPN american_scientific_journal-3226 170 15 , , PUNCT american_scientific_journal-3226 170 16 dl dl PROPN american_scientific_journal-3226 170 17 kelly kelly PROPN american_scientific_journal-3226 170 18 , , PUNCT american_scientific_journal-3226 170 19 wj wj PROPN american_scientific_journal-3226 170 20 catalona catalona PROPN american_scientific_journal-3226 170 21 , , PUNCT american_scientific_journal-3226 170 22 xj xj PROPN american_scientific_journal-3226 170 23 yang yang PROPN american_scientific_journal-3226 170 24 , , PUNCT american_scientific_journal-3226 170 25 m m NOUN american_scientific_journal-3226 170 26 pins pin NOUN american_scientific_journal-3226 170 27 , , PUNCT american_scientific_journal-3226 170 28 v v NOUN american_scientific_journal-3226 170 29 ananthanarayanan ananthanarayanan NOUN american_scientific_journal-3226 170 30 , , PUNCT american_scientific_journal-3226 170 31 rc rc PROPN american_scientific_journal-3226 170 32 bergan bergan NOUN american_scientific_journal-3226 170 33 . . PUNCT american_scientific_journal-3226 171 1 “ " PUNCT american_scientific_journal-3226 171 2 characterization characterization NOUN american_scientific_journal-3226 171 3 of of ADP american_scientific_journal-3226 171 4 a a DET american_scientific_journal-3226 171 5 method method NOUN american_scientific_journal-3226 171 6 for for ADP american_scientific_journal-3226 171 7 profiling profile VERB american_scientific_journal-3226 171 8 gene gene NOUN american_scientific_journal-3226 171 9 expression expression NOUN american_scientific_journal-3226 171 10 in in ADP american_scientific_journal-3226 171 11 cells cell NOUN american_scientific_journal-3226 171 12 recovered recover VERB american_scientific_journal-3226 171 13 from from ADP american_scientific_journal-3226 171 14 intact intact ADJ american_scientific_journal-3226 171 15 human human ADJ american_scientific_journal-3226 171 16 prostate prostate NOUN american_scientific_journal-3226 171 17 tissue tissue NOUN american_scientific_journal-3226 171 18 using use VERB american_scientific_journal-3226 171 19 rna rna NOUN american_scientific_journal-3226 171 20 linear linear ADJ american_scientific_journal-3226 171 21 amplification amplification NOUN american_scientific_journal-3226 171 22 . . PUNCT american_scientific_journal-3226 171 23 ” " PUNCT american_scientific_journal-3226 172 1 prostate prostate NOUN american_scientific_journal-3226 172 2 cancer cancer NOUN american_scientific_journal-3226 172 3 prostatic prostatic ADJ american_scientific_journal-3226 172 4 dis dis PROPN american_scientific_journal-3226 172 5 , , PUNCT american_scientific_journal-3226 172 6 vol vol NOUN american_scientific_journal-3226 172 7 . . PUNCT american_scientific_journal-3226 172 8 9(4 9(4 NOUN american_scientific_journal-3226 172 9 ) ) PUNCT american_scientific_journal-3226 172 10 , , PUNCT american_scientific_journal-3226 172 11 pp pp ADP american_scientific_journal-3226 172 12 . . PUNCT american_scientific_journal-3226 173 1 379–91 379–91 NUM american_scientific_journal-3226 173 2 . . PUNCT american_scientific_journal-3226 174 1 2006 2006 NUM american_scientific_journal-3226 174 2 . . PUNCT american_scientific_journal-3226 175 1 [ [ X american_scientific_journal-3226 175 2 16 16 NUM american_scientific_journal-3226 175 3 ] ] PUNCT american_scientific_journal-3226 175 4 . . PUNCT american_scientific_journal-3226 176 1 m m PROPN american_scientific_journal-3226 176 2 azhar azhar PROPN american_scientific_journal-3226 176 3 , , PUNCT american_scientific_journal-3226 176 4 d d PROPN american_scientific_journal-3226 176 5 natalia natalia PROPN american_scientific_journal-3226 176 6 , , PUNCT american_scientific_journal-3226 176 7 s s PART american_scientific_journal-3226 176 8 syukur syukur NOUN american_scientific_journal-3226 176 9 , , PUNCT american_scientific_journal-3226 176 10 vovien vovien NOUN american_scientific_journal-3226 176 11 , , PUNCT american_scientific_journal-3226 176 12 and and CCONJ american_scientific_journal-3226 176 13 jamasari jamasari PROPN american_scientific_journal-3226 176 14 . . PUNCT american_scientific_journal-3226 177 1 “ " PUNCT american_scientific_journal-3226 177 2 gene gene NOUN american_scientific_journal-3226 177 3 fragments fragment NOUN american_scientific_journal-3226 177 4 that that PRON american_scientific_journal-3226 177 5 encodes encode VERB american_scientific_journal-3226 177 6 inulin inulin ADJ american_scientific_journal-3226 177 7 hydrolysis hydrolysis NOUN american_scientific_journal-3226 177 8 enzyme enzyme NOUN american_scientific_journal-3226 177 9 from from ADP american_scientific_journal-3226 177 10 genomic genomic ADJ american_scientific_journal-3226 177 11 bacillus bacillus NOUN american_scientific_journal-3226 177 12 licheniformis licheniformis NOUN american_scientific_journal-3226 177 13 : : PUNCT american_scientific_journal-3226 177 14 isolation isolation NOUN american_scientific_journal-3226 177 15 by by ADP american_scientific_journal-3226 177 16 pcr pcr ADJ american_scientific_journal-3226 177 17 technique technique NOUN american_scientific_journal-3226 177 18 using use VERB american_scientific_journal-3226 177 19 new new ADJ american_scientific_journal-3226 177 20 primers primer NOUN american_scientific_journal-3226 177 21 . . PUNCT american_scientific_journal-3226 177 22 ” " PUNCT american_scientific_journal-3226 178 1 international international ADJ american_scientific_journal-3226 178 2 journal journal NOUN american_scientific_journal-3226 178 3 of of ADP american_scientific_journal-3226 178 4 biological biological ADJ american_scientific_journal-3226 178 5 chemistry chemistry NOUN american_scientific_journal-3226 178 6 , , PUNCT american_scientific_journal-3226 178 7 vol vol NOUN american_scientific_journal-3226 178 8 . . PUNCT american_scientific_journal-3226 178 9 9(2 9(2 NUM american_scientific_journal-3226 178 10 ) ) PUNCT american_scientific_journal-3226 178 11 , , PUNCT american_scientific_journal-3226 178 12 pp pp ADP american_scientific_journal-3226 178 13 . . PUNCT american_scientific_journal-3226 179 1 59 59 NUM american_scientific_journal-3226 179 2 . . NUM american_scientific_journal-3226 179 3 2015 2015 NUM american_scientific_journal-3226 179 4 . . PUNCT american_scientific_journal-3226 180 1 american american ADJ american_scientific_journal-3226 180 2 scientific scientific ADJ american_scientific_journal-3226 180 3 research research PROPN american_scientific_journal-3226 180 4 journal journal NOUN american_scientific_journal-3226 180 5 for for ADP american_scientific_journal-3226 180 6 engineering engineering NOUN american_scientific_journal-3226 180 7 , , PUNCT american_scientific_journal-3226 180 8 technology technology NOUN american_scientific_journal-3226 180 9 , , PUNCT american_scientific_journal-3226 180 10 and and CCONJ american_scientific_journal-3226 180 11 sciences science NOUN american_scientific_journal-3226 180 12 ( ( PUNCT american_scientific_journal-3226 180 13 asrjets asrjet NOUN american_scientific_journal-3226 180 14 ) ) PUNCT american_scientific_journal-3226 180 15 ( ( PUNCT american_scientific_journal-3226 180 16 2017 2017 NUM american_scientific_journal-3226 180 17 ) ) PUNCT american_scientific_journal-3226 180 18 volume volume NOUN american_scientific_journal-3226 180 19 35 35 NUM american_scientific_journal-3226 180 20 , , PUNCT american_scientific_journal-3226 180 21 no no DET american_scientific_journal-3226 180 22 1 1 NUM american_scientific_journal-3226 180 23 , , PUNCT american_scientific_journal-3226 180 24 pp pp ADV american_scientific_journal-3226 180 25 8 8 NUM american_scientific_journal-3226 180 26 - - SYM american_scientific_journal-3226 180 27 14 14 NUM american_scientific_journal-3226 180 28 14 14 NUM american_scientific_journal-3226 181 1 [ [ X american_scientific_journal-3226 181 2 17 17 NUM american_scientific_journal-3226 181 3 ] ] PUNCT american_scientific_journal-3226 181 4 . . PUNCT american_scientific_journal-3226 182 1 campos campos PROPN american_scientific_journal-3226 182 2 . . PUNCT american_scientific_journal-3226 183 1 “ " PUNCT american_scientific_journal-3226 183 2 dna dna NOUN american_scientific_journal-3226 183 3 extraction extraction NOUN american_scientific_journal-3226 183 4 from from ADP american_scientific_journal-3226 183 5 formalin formalin NOUN american_scientific_journal-3226 183 6 - - PUNCT american_scientific_journal-3226 183 7 fixed fix VERB american_scientific_journal-3226 183 8 material material NOUN american_scientific_journal-3226 183 9 . . PUNCT american_scientific_journal-3226 183 10 ” " PUNCT american_scientific_journal-3226 184 1 methods method NOUN american_scientific_journal-3226 184 2 in in ADP american_scientific_journal-3226 184 3 molecular molecular ADJ american_scientific_journal-3226 184 4 biology biology NOUN american_scientific_journal-3226 184 5 . . PUNCT american_scientific_journal-3226 185 1 january january PROPN american_scientific_journal-3226 185 2 , , PUNCT american_scientific_journal-3226 185 3 2012 2012 NUM american_scientific_journal-3226 185 4 . . PUNCT american_scientific_journal-3226 186 1 [ [ X american_scientific_journal-3226 186 2 18 18 NUM american_scientific_journal-3226 186 3 ] ] PUNCT american_scientific_journal-3226 186 4 . . PUNCT american_scientific_journal-3226 187 1 j j PROPN american_scientific_journal-3226 187 2 jozefczuk jozefczuk PROPN american_scientific_journal-3226 187 3 , , PUNCT american_scientific_journal-3226 187 4 h h PROPN american_scientific_journal-3226 187 5 stachelscheid stachelscheid PROPN american_scientific_journal-3226 187 6 , , PUNCT american_scientific_journal-3226 187 7 l l PROPN american_scientific_journal-3226 187 8 chavez chavez PROPN american_scientific_journal-3226 187 9 , , PUNCT american_scientific_journal-3226 187 10 r r PROPN american_scientific_journal-3226 187 11 herwig herwig PROPN american_scientific_journal-3226 187 12 , , PUNCT american_scientific_journal-3226 187 13 h h NOUN american_scientific_journal-3226 187 14 lehrach lehrach VERB american_scientific_journal-3226 187 15 , , PUNCT american_scientific_journal-3226 187 16 k k PROPN american_scientific_journal-3226 187 17 zeilinger zeilinger PROPN american_scientific_journal-3226 187 18 , , PUNCT american_scientific_journal-3226 187 19 jc jc PROPN american_scientific_journal-3226 187 20 gerlach gerlach PROPN american_scientific_journal-3226 187 21 , , PUNCT american_scientific_journal-3226 187 22 and and CCONJ american_scientific_journal-3226 187 23 j j PROPN american_scientific_journal-3226 187 24 adjaye adjaye NOUN american_scientific_journal-3226 187 25 . . PUNCT american_scientific_journal-3226 188 1 “ " PUNCT american_scientific_journal-3226 188 2 molecular molecular ADJ american_scientific_journal-3226 188 3 characterization characterization NOUN american_scientific_journal-3226 188 4 of of ADP american_scientific_journal-3226 188 5 cultured cultured ADJ american_scientific_journal-3226 188 6 adult adult NOUN american_scientific_journal-3226 188 7 human human ADJ american_scientific_journal-3226 188 8 liver liver NOUN american_scientific_journal-3226 188 9 progenitor progenitor NOUN american_scientific_journal-3226 188 10 cells cell NOUN american_scientific_journal-3226 188 11 . . PUNCT american_scientific_journal-3226 188 12 ” " PUNCT american_scientific_journal-3226 189 1 tissue tissue NOUN american_scientific_journal-3226 189 2 eng eng PROPN american_scientific_journal-3226 189 3 . . PUNCT american_scientific_journal-3226 190 1 part part NOUN american_scientific_journal-3226 190 2 c c PROPN american_scientific_journal-3226 190 3 methods method NOUN american_scientific_journal-3226 190 4 , , PUNCT american_scientific_journal-3226 190 5 vol vol NOUN american_scientific_journal-3226 190 6 . . PUNCT american_scientific_journal-3226 191 1 16(5 16(5 NUM american_scientific_journal-3226 191 2 ) ) PUNCT american_scientific_journal-3226 191 3 , , PUNCT american_scientific_journal-3226 192 1 pp pp PROPN american_scientific_journal-3226 192 2 . . PUNCT american_scientific_journal-3226 193 1 821–34 821–34 NUM american_scientific_journal-3226 193 2 . . PUNCT american_scientific_journal-3226 194 1 2010 2010 NUM american_scientific_journal-3226 194 2 . . PUNCT american_scientific_journal-3226 195 1 [ [ X american_scientific_journal-3226 195 2 19 19 NUM american_scientific_journal-3226 195 3 ] ] PUNCT american_scientific_journal-3226 195 4 . . PUNCT american_scientific_journal-3226 196 1 r r NOUN american_scientific_journal-3226 196 2 boland boland NOUN american_scientific_journal-3226 196 3 and and CCONJ american_scientific_journal-3226 196 4 l l NOUN american_scientific_journal-3226 196 5 riccardiello riccardiello NOUN american_scientific_journal-3226 196 6 . . PUNCT american_scientific_journal-3226 197 1 “ " PUNCT american_scientific_journal-3226 197 2 how how SCONJ american_scientific_journal-3226 197 3 many many ADJ american_scientific_journal-3226 197 4 mutations mutation NOUN american_scientific_journal-3226 197 5 does do AUX american_scientific_journal-3226 197 6 it it PRON american_scientific_journal-3226 197 7 take take VERB american_scientific_journal-3226 197 8 to to PART american_scientific_journal-3226 197 9 make make VERB american_scientific_journal-3226 197 10 a a DET american_scientific_journal-3226 197 11 tumor tumor NOUN american_scientific_journal-3226 197 12 ? ? PUNCT american_scientific_journal-3226 197 13 ” " PUNCT american_scientific_journal-3226 198 1 proc proc PROPN american_scientific_journal-3226 198 2 natl natl PROPN american_scientific_journal-3226 198 3 acad acad PROPN american_scientific_journal-3226 198 4 sci sci PROPN american_scientific_journal-3226 198 5 usa usa PROPN american_scientific_journal-3226 198 6 , , PUNCT american_scientific_journal-3226 198 7 vol vol NOUN american_scientific_journal-3226 198 8 . . PROPN american_scientific_journal-3226 198 9 96 96 NUM american_scientific_journal-3226 198 10 , , PUNCT american_scientific_journal-3226 198 11 pp pp ADJ american_scientific_journal-3226 198 12 . . PUNCT american_scientific_journal-3226 198 13 14675 14675 NUM american_scientific_journal-3226 198 14 - - SYM american_scientific_journal-3226 198 15 7 7 NUM american_scientific_journal-3226 198 16 . . NOUN american_scientific_journal-3226 198 17 1999 1999 NUM american_scientific_journal-3226 198 18 . . PUNCT american_scientific_journal-3226 199 1 [ [ X american_scientific_journal-3226 199 2 20 20 NUM american_scientific_journal-3226 199 3 ] ] PUNCT american_scientific_journal-3226 199 4 . . PUNCT american_scientific_journal-3226 200 1 mj mj PROPN american_scientific_journal-3226 200 2 renan renan PROPN american_scientific_journal-3226 200 3 . . PUNCT american_scientific_journal-3226 201 1 “ " PUNCT american_scientific_journal-3226 201 2 how how SCONJ american_scientific_journal-3226 201 3 many many ADJ american_scientific_journal-3226 201 4 mutations mutation NOUN american_scientific_journal-3226 201 5 are be AUX american_scientific_journal-3226 201 6 required require VERB american_scientific_journal-3226 201 7 for for ADP american_scientific_journal-3226 201 8 tumorigenesis tumorigenesis NOUN american_scientific_journal-3226 201 9 ? ? PUNCT american_scientific_journal-3226 202 1 implications implication NOUN american_scientific_journal-3226 202 2 from from ADP american_scientific_journal-3226 202 3 human human ADJ american_scientific_journal-3226 202 4 cancer cancer NOUN american_scientific_journal-3226 202 5 data datum NOUN american_scientific_journal-3226 202 6 . . PUNCT american_scientific_journal-3226 202 7 ” " PUNCT american_scientific_journal-3226 203 1 molecular molecular ADJ american_scientific_journal-3226 203 2 carcinogenesis carcinogenesis NOUN american_scientific_journal-3226 203 3 , , PUNCT american_scientific_journal-3226 203 4 vol vol NOUN american_scientific_journal-3226 203 5 . . PROPN american_scientific_journal-3226 203 6 7 7 NUM american_scientific_journal-3226 203 7 , , PUNCT american_scientific_journal-3226 203 8 pp pp ADJ american_scientific_journal-3226 203 9 . . PUNCT american_scientific_journal-3226 204 1 139 139 NUM american_scientific_journal-3226 204 2 – – PUNCT american_scientific_journal-3226 204 3 146 146 NUM american_scientific_journal-3226 204 4 . . PUNCT american_scientific_journal-3226 204 5 1993 1993 NUM american_scientific_journal-3226 204 6 . . PUNCT american_scientific_journal-3226 205 1 [ [ X american_scientific_journal-3226 205 2 21 21 NUM american_scientific_journal-3226 205 3 ] ] PUNCT american_scientific_journal-3226 205 4 . . PUNCT american_scientific_journal-3226 206 1 r r NOUN american_scientific_journal-3226 206 2 bernards bernard NOUN american_scientific_journal-3226 206 3 and and CCONJ american_scientific_journal-3226 206 4 ra ra PROPN american_scientific_journal-3226 206 5 weinberg weinberg PROPN american_scientific_journal-3226 206 6 . . PUNCT american_scientific_journal-3226 207 1 “ " PUNCT american_scientific_journal-3226 207 2 a a DET american_scientific_journal-3226 207 3 progression progression NOUN american_scientific_journal-3226 207 4 puzzle puzzle NOUN american_scientific_journal-3226 207 5 – – PUNCT american_scientific_journal-3226 207 6 metastasis metastasis NOUN american_scientific_journal-3226 207 7 genes gene NOUN american_scientific_journal-3226 207 8 . . PUNCT american_scientific_journal-3226 207 9 ” " PUNCT american_scientific_journal-3226 208 1 nature nature NOUN american_scientific_journal-3226 208 2 , , PUNCT american_scientific_journal-3226 208 3 vol vol NOUN american_scientific_journal-3226 208 4 . . PROPN american_scientific_journal-3226 208 5 418 418 NUM american_scientific_journal-3226 208 6 , , PUNCT american_scientific_journal-3226 208 7 pp pp ADJ american_scientific_journal-3226 208 8 . . PUNCT american_scientific_journal-3226 208 9 823 823 NUM american_scientific_journal-3226 208 10 . . PUNCT american_scientific_journal-3226 208 11 2002 2002 NUM american_scientific_journal-3226 208 12 . . PUNCT american_scientific_journal-3226 209 1 [ [ X american_scientific_journal-3226 209 2 22 22 NUM american_scientific_journal-3226 209 3 ] ] PUNCT american_scientific_journal-3226 209 4 . . PUNCT american_scientific_journal-3226 210 1 tm tm PROPN american_scientific_journal-3226 210 2 pisansky pisansky PROPN american_scientific_journal-3226 210 3 , , PUNCT american_scientific_journal-3226 210 4 mj mj PROPN american_scientific_journal-3226 210 5 kahn kahn PROPN american_scientific_journal-3226 210 6 , , PUNCT american_scientific_journal-3226 210 7 dg dg PROPN american_scientific_journal-3226 210 8 bostwick bostwick PROPN american_scientific_journal-3226 210 9 . . PUNCT american_scientific_journal-3226 211 1 “ " PUNCT american_scientific_journal-3226 211 2 an an DET american_scientific_journal-3226 211 3 enhanced enhanced ADJ american_scientific_journal-3226 211 4 progostic progostic ADJ american_scientific_journal-3226 211 5 system system NOUN american_scientific_journal-3226 211 6 for for ADP american_scientific_journal-3226 211 7 clinically clinically ADV american_scientific_journal-3226 211 8 localized localize VERB american_scientific_journal-3226 211 9 carcinoma carcinoma NOUN american_scientific_journal-3226 211 10 of of ADP american_scientific_journal-3226 211 11 the the DET american_scientific_journal-3226 211 12 prostate prostate NOUN american_scientific_journal-3226 211 13 . . PUNCT american_scientific_journal-3226 211 14 ” " PUNCT american_scientific_journal-3226 212 1 cancer cancer NOUN american_scientific_journal-3226 212 2 , , PUNCT american_scientific_journal-3226 212 3 vol vol NOUN american_scientific_journal-3226 212 4 . . PROPN american_scientific_journal-3226 212 5 79 79 NUM american_scientific_journal-3226 212 6 , , PUNCT american_scientific_journal-3226 212 7 pp pp ADJ american_scientific_journal-3226 212 8 . . PUNCT american_scientific_journal-3226 212 9 2154 2154 NUM american_scientific_journal-3226 212 10 - - SYM american_scientific_journal-3226 212 11 2161 2161 NUM american_scientific_journal-3226 212 12 . . PUNCT american_scientific_journal-3226 213 1 1997 1997 NUM american_scientific_journal-3226 213 2 . . PUNCT american_scientific_journal-3226 214 1 [ [ X american_scientific_journal-3226 214 2 23 23 NUM american_scientific_journal-3226 214 3 ] ] PUNCT american_scientific_journal-3226 214 4 . . PUNCT american_scientific_journal-3226 215 1 w w PROPN american_scientific_journal-3226 215 2 coleman coleman PROPN american_scientific_journal-3226 215 3 , , PUNCT american_scientific_journal-3226 215 4 and and CCONJ american_scientific_journal-3226 215 5 g g PROPN american_scientific_journal-3226 215 6 tsongalis tsongali NOUN american_scientific_journal-3226 215 7 . . PUNCT american_scientific_journal-3226 216 1 “ " PUNCT american_scientific_journal-3226 216 2 the the DET american_scientific_journal-3226 216 3 molecular molecular ADJ american_scientific_journal-3226 216 4 basis basis NOUN american_scientific_journal-3226 216 5 of of ADP american_scientific_journal-3226 216 6 human human ADJ american_scientific_journal-3226 216 7 cancer cancer NOUN american_scientific_journal-3226 216 8 ( ( PUNCT american_scientific_journal-3226 216 9 1 1 NUM american_scientific_journal-3226 216 10 st st NOUN american_scientific_journal-3226 216 11 ) ) PUNCT american_scientific_journal-3226 216 12 . . PUNCT american_scientific_journal-3226 216 13 ” " PUNCT american_scientific_journal-3226 217 1 humana humana PROPN american_scientific_journal-3226 217 2 press press PROPN american_scientific_journal-3226 217 3 inc inc PROPN american_scientific_journal-3226 217 4 . . PROPN american_scientific_journal-3226 217 5 2002 2002 NUM american_scientific_journal-3226 217 6 . . PUNCT american_scientific_journal-3226 218 1 [ [ X american_scientific_journal-3226 218 2 24 24 NUM american_scientific_journal-3226 218 3 ] ] PUNCT american_scientific_journal-3226 218 4 . . PUNCT american_scientific_journal-3226 219 1 f f PROPN american_scientific_journal-3226 219 2 macdonald macdonald PROPN american_scientific_journal-3226 219 3 , , PUNCT american_scientific_journal-3226 219 4 chj chj PROPN american_scientific_journal-3226 219 5 ford ford PROPN american_scientific_journal-3226 219 6 , , PUNCT american_scientific_journal-3226 219 7 and and CCONJ american_scientific_journal-3226 219 8 ag ag PROPN american_scientific_journal-3226 219 9 casson casson PROPN american_scientific_journal-3226 219 10 . . PUNCT american_scientific_journal-3226 220 1 “ " PUNCT american_scientific_journal-3226 220 2 molecular molecular ADJ american_scientific_journal-3226 220 3 biology biology NOUN american_scientific_journal-3226 220 4 of of ADP american_scientific_journal-3226 220 5 cancer cancer NOUN american_scientific_journal-3226 220 6 ” " PUNCT american_scientific_journal-3226 220 7 in in ADP american_scientific_journal-3226 220 8 macdonald macdonald PROPN american_scientific_journal-3226 220 9 , , PUNCT american_scientific_journal-3226 220 10 2nd 2nd ADJ american_scientific_journal-3226 220 11 ed ed NOUN american_scientific_journal-3226 220 12 , , PUNCT american_scientific_journal-3226 220 13 2004 2004 NUM american_scientific_journal-3226 220 14 . . PUNCT american_scientific_journal-3226 221 1 [ [ X american_scientific_journal-3226 221 2 25 25 NUM american_scientific_journal-3226 221 3 ] ] PUNCT american_scientific_journal-3226 221 4 . . PUNCT american_scientific_journal-3226 222 1 tj tj PROPN american_scientific_journal-3226 222 2 mcdonnell mcdonnell PROPN american_scientific_journal-3226 222 3 , , PUNCT american_scientific_journal-3226 222 4 p p NOUN american_scientific_journal-3226 222 5 troncoso troncoso NOUN american_scientific_journal-3226 222 6 , , PUNCT american_scientific_journal-3226 222 7 sm sm PROPN american_scientific_journal-3226 222 8 brisbay brisbay PROPN american_scientific_journal-3226 222 9 , , PUNCT american_scientific_journal-3226 222 10 c c PROPN american_scientific_journal-3226 222 11 logothetis logothetis PROPN american_scientific_journal-3226 222 12 , , PUNCT american_scientific_journal-3226 222 13 lwk lwk PROPN american_scientific_journal-3226 222 14 chung chung PROPN american_scientific_journal-3226 222 15 , , PUNCT american_scientific_journal-3226 222 16 jt jt PROPN american_scientific_journal-3226 222 17 hsieh hsieh PROPN american_scientific_journal-3226 222 18 , , PUNCT american_scientific_journal-3226 222 19 sm sm PROPN american_scientific_journal-3226 222 20 tu tu PROPN american_scientific_journal-3226 222 21 , , PUNCT american_scientific_journal-3226 222 22 and and CCONJ american_scientific_journal-3226 222 23 ml ml X american_scientific_journal-3226 222 24 campbell campbell PROPN american_scientific_journal-3226 222 25 . . PUNCT american_scientific_journal-3226 223 1 “ " PUNCT american_scientific_journal-3226 223 2 expression expression NOUN american_scientific_journal-3226 223 3 of of ADP american_scientific_journal-3226 223 4 the the DET american_scientific_journal-3226 223 5 protooncogene protooncogene NOUN american_scientific_journal-3226 223 6 bcl-2 bcl-2 VERB american_scientific_journal-3226 223 7 in in ADP american_scientific_journal-3226 223 8 the the DET american_scientific_journal-3226 223 9 prostate prostate NOUN american_scientific_journal-3226 223 10 and and CCONJ american_scientific_journal-3226 223 11 its its PRON american_scientific_journal-3226 223 12 association association NOUN american_scientific_journal-3226 223 13 with with ADP american_scientific_journal-3226 223 14 emergence emergence NOUN american_scientific_journal-3226 223 15 of of ADP american_scientific_journal-3226 223 16 androgen androgen NOUN american_scientific_journal-3226 223 17 - - PUNCT american_scientific_journal-3226 223 18 independent independent ADJ american_scientific_journal-3226 223 19 prostate prostate NOUN american_scientific_journal-3226 223 20 cancer cancer NOUN american_scientific_journal-3226 223 21 . . PUNCT american_scientific_journal-3226 223 22 ” " PUNCT american_scientific_journal-3226 224 1 cancer cancer NOUN american_scientific_journal-3226 224 2 res re NOUN american_scientific_journal-3226 224 3 . . PUNCT american_scientific_journal-3226 224 4 , , PUNCT american_scientific_journal-3226 224 5 vol vol NOUN american_scientific_journal-3226 224 6 . . PROPN american_scientific_journal-3226 225 1 52 52 NUM american_scientific_journal-3226 225 2 , , PUNCT american_scientific_journal-3226 225 3 pp pp ADJ american_scientific_journal-3226 225 4 . . PUNCT american_scientific_journal-3226 226 1 6940 6940 NUM american_scientific_journal-3226 226 2 - - SYM american_scientific_journal-3226 226 3 4 4 NUM american_scientific_journal-3226 226 4 . . NOUN american_scientific_journal-3226 226 5 1992 1992 NUM american_scientific_journal-3226 226 6 . . PUNCT american_scientific_journal-3226 227 1 [ [ X american_scientific_journal-3226 227 2 26 26 NUM american_scientific_journal-3226 227 3 ] ] PUNCT american_scientific_journal-3226 227 4 . . PUNCT american_scientific_journal-3226 228 1 gj gj PROPN american_scientific_journal-3226 228 2 berchem berchem PROPN american_scientific_journal-3226 228 3 , , PUNCT american_scientific_journal-3226 228 4 m m NOUN american_scientific_journal-3226 228 5 bosseler bosseler NOUN american_scientific_journal-3226 228 6 , , PUNCT american_scientific_journal-3226 228 7 ly ly ADP american_scientific_journal-3226 228 8 sugars sugar NOUN american_scientific_journal-3226 228 9 , , PUNCT american_scientific_journal-3226 228 10 hj hj PROPN american_scientific_journal-3226 228 11 voeller voeller NOUN american_scientific_journal-3226 228 12 , , PUNCT american_scientific_journal-3226 228 13 s s VERB american_scientific_journal-3226 228 14 zeitlin zeitlin PROPN american_scientific_journal-3226 228 15 , , PUNCT american_scientific_journal-3226 228 16 et et PROPN american_scientific_journal-3226 228 17 al al PROPN american_scientific_journal-3226 228 18 . . PUNCT american_scientific_journal-3226 229 1 “ " PUNCT american_scientific_journal-3226 229 2 androgens androgen NOUN american_scientific_journal-3226 229 3 induce induce VERB american_scientific_journal-3226 229 4 resistance resistance NOUN american_scientific_journal-3226 229 5 to to ADP american_scientific_journal-3226 229 6 bcl2 bcl2 NOUN american_scientific_journal-3226 229 7 - - PUNCT american_scientific_journal-3226 229 8 mediated mediate VERB american_scientific_journal-3226 229 9 apoptosis apoptosis NOUN american_scientific_journal-3226 229 10 in in ADP american_scientific_journal-3226 229 11 lncap lncap NOUN american_scientific_journal-3226 229 12 prostate prostate NOUN american_scientific_journal-3226 229 13 cancer cancer NOUN american_scientific_journal-3226 229 14 cells cell NOUN american_scientific_journal-3226 229 15 . . PUNCT american_scientific_journal-3226 229 16 ” " PUNCT american_scientific_journal-3226 230 1 cancer cancer NOUN american_scientific_journal-3226 230 2 res re NOUN american_scientific_journal-3226 230 3 , , PUNCT american_scientific_journal-3226 230 4 vol vol NOUN american_scientific_journal-3226 230 5 . . PROPN american_scientific_journal-3226 230 6 55 55 NUM american_scientific_journal-3226 230 7 , , PUNCT american_scientific_journal-3226 230 8 pp pp ADJ american_scientific_journal-3226 230 9 . . PUNCT american_scientific_journal-3226 231 1 735 735 NUM american_scientific_journal-3226 231 2 - - SYM american_scientific_journal-3226 231 3 8 8 NUM american_scientific_journal-3226 231 4 . . NOUN american_scientific_journal-3226 232 1 1995 1995 NUM american_scientific_journal-3226 232 2 . . PUNCT american_scientific_journal-3226 233 1 [ [ X american_scientific_journal-3226 233 2 27 27 NUM american_scientific_journal-3226 233 3 ] ] PUNCT american_scientific_journal-3226 233 4 . . PUNCT american_scientific_journal-3226 234 1 p p VERB american_scientific_journal-3226 234 2 rodriguez rodriguez NOUN american_scientific_journal-3226 234 3 - - PUNCT american_scientific_journal-3226 234 4 tome tome NOUN american_scientific_journal-3226 234 5 , , PUNCT american_scientific_journal-3226 234 6 t t PROPN american_scientific_journal-3226 234 7 flores flore NOUN american_scientific_journal-3226 234 8 , , PUNCT american_scientific_journal-3226 234 9 m m VERB american_scientific_journal-3226 234 10 hollstein hollstein ADJ american_scientific_journal-3226 234 11 , , PUNCT american_scientific_journal-3226 234 12 cc cc PROPN american_scientific_journal-3226 234 13 harris harris PROPN american_scientific_journal-3226 234 14 , , PUNCT american_scientific_journal-3226 234 15 r r PROPN american_scientific_journal-3226 234 16 montesano montesano PROPN american_scientific_journal-3226 234 17 . . PUNCT american_scientific_journal-3226 235 1 “ " PUNCT american_scientific_journal-3226 235 2 iarc iarc NOUN american_scientific_journal-3226 235 3 database database NOUN american_scientific_journal-3226 235 4 of of ADP american_scientific_journal-3226 235 5 p53 p53 NOUN american_scientific_journal-3226 235 6 gene gene NOUN american_scientific_journal-3226 235 7 mutations mutation NOUN american_scientific_journal-3226 235 8 in in ADP american_scientific_journal-3226 235 9 human human ADJ american_scientific_journal-3226 235 10 tumors tumor NOUN american_scientific_journal-3226 235 11 and and CCONJ american_scientific_journal-3226 235 12 cell cell NOUN american_scientific_journal-3226 235 13 lines line NOUN american_scientific_journal-3226 235 14 : : PUNCT american_scientific_journal-3226 235 15 updated update VERB american_scientific_journal-3226 235 16 compilation compilation NOUN american_scientific_journal-3226 235 17 , , PUNCT american_scientific_journal-3226 235 18 revised revise VERB american_scientific_journal-3226 235 19 formats format NOUN american_scientific_journal-3226 235 20 and and CCONJ american_scientific_journal-3226 235 21 new new ADJ american_scientific_journal-3226 235 22 visualisation visualisation NOUN american_scientific_journal-3226 235 23 tools tool NOUN american_scientific_journal-3226 235 24 . . PUNCT american_scientific_journal-3226 235 25 ” " PUNCT american_scientific_journal-3226 236 1 nucleic nucleic ADJ american_scientific_journal-3226 236 2 acids acid NOUN american_scientific_journal-3226 236 3 research research NOUN american_scientific_journal-3226 236 4 , , PUNCT american_scientific_journal-3226 236 5 vol vol NOUN american_scientific_journal-3226 236 6 . . PROPN american_scientific_journal-3226 236 7 26 26 NUM american_scientific_journal-3226 236 8 , , PUNCT american_scientific_journal-3226 236 9 pp pp ADJ american_scientific_journal-3226 236 10 . . NOUN american_scientific_journal-3226 236 11 205 205 NUM american_scientific_journal-3226 236 12 – – PUNCT american_scientific_journal-3226 236 13 213 213 NUM american_scientific_journal-3226 236 14 . . PUNCT american_scientific_journal-3226 236 15 1998 1998 NUM american_scientific_journal-3226 236 16 . . PUNCT american_scientific_journal-3226 237 1 [ [ X american_scientific_journal-3226 237 2 28 28 NUM american_scientific_journal-3226 237 3 ] ] PUNCT american_scientific_journal-3226 237 4 . . PUNCT american_scientific_journal-3226 238 1 th th X american_scientific_journal-3226 238 2 ecke ecke PROPN american_scientific_journal-3226 238 3 , , PUNCT american_scientific_journal-3226 238 4 hh hh PROPN american_scientific_journal-3226 238 5 schlechte schlechte PROPN american_scientific_journal-3226 238 6 , , PUNCT american_scientific_journal-3226 238 7 a a DET american_scientific_journal-3226 238 8 hübsch hübsch PROPN american_scientific_journal-3226 238 9 , , PUNCT american_scientific_journal-3226 238 10 sv sv PROPN american_scientific_journal-3226 238 11 lenk lenk PROPN american_scientific_journal-3226 238 12 , , PUNCT american_scientific_journal-3226 238 13 k k PROPN american_scientific_journal-3226 238 14 schiemenz schiemenz PROPN american_scientific_journal-3226 238 15 , , PUNCT american_scientific_journal-3226 238 16 bd bd PROPN american_scientific_journal-3226 238 17 rudolph rudolph PROPN american_scientific_journal-3226 238 18 , , PUNCT american_scientific_journal-3226 238 19 k k PROPN american_scientific_journal-3226 238 20 miller miller PROPN american_scientific_journal-3226 238 21 . . PUNCT american_scientific_journal-3226 239 1 “ " PUNCT american_scientific_journal-3226 239 2 tp53mutation tp53mutation VERB american_scientific_journal-3226 239 3 in in ADP american_scientific_journal-3226 239 4 prostate prostate NOUN american_scientific_journal-3226 239 5 needle needle NOUN american_scientific_journal-3226 239 6 biopsies biopsy NOUN american_scientific_journal-3226 239 7 – – PUNCT american_scientific_journal-3226 239 8 comparison comparison NOUN american_scientific_journal-3226 239 9 with with ADP american_scientific_journal-3226 239 10 patients patient NOUN american_scientific_journal-3226 239 11 follow follow VERB american_scientific_journal-3226 239 12 - - PUNCT american_scientific_journal-3226 239 13 up up NOUN american_scientific_journal-3226 239 14 . . PUNCT american_scientific_journal-3226 239 15 ” " PUNCT american_scientific_journal-3226 240 1 anticancer anticancer NOUN american_scientific_journal-3226 240 2 res re NOUN american_scientific_journal-3226 240 3 , , PUNCT american_scientific_journal-3226 240 4 vol vol NOUN american_scientific_journal-3226 240 5 . . PUNCT american_scientific_journal-3226 240 6 27(6 27(6 NUM american_scientific_journal-3226 240 7 ) ) PUNCT american_scientific_journal-3226 240 8 , , PUNCT american_scientific_journal-3226 240 9 pp pp ADP american_scientific_journal-3226 240 10 . . PUNCT american_scientific_journal-3226 241 1 4143 4143 NUM american_scientific_journal-3226 241 2 - - SYM american_scientific_journal-3226 241 3 8 8 NUM american_scientific_journal-3226 241 4 . . NOUN american_scientific_journal-3226 241 5 2007 2007 NUM american_scientific_journal-3226 241 6 . . PUNCT american_scientific_journal-3226 242 1 [ [ X american_scientific_journal-3226 242 2 29 29 NUM american_scientific_journal-3226 242 3 ] ] PUNCT american_scientific_journal-3226 242 4 . . PUNCT american_scientific_journal-3226 243 1 d d X american_scientific_journal-3226 243 2 sidransky sidransky PROPN american_scientific_journal-3226 243 3 and and CCONJ american_scientific_journal-3226 243 4 m m AUX american_scientific_journal-3226 243 5 hollstein hollstein ADJ american_scientific_journal-3226 243 6 . . PUNCT american_scientific_journal-3226 244 1 “ " PUNCT american_scientific_journal-3226 244 2 clinical clinical ADJ american_scientific_journal-3226 244 3 implications implication NOUN american_scientific_journal-3226 244 4 of of ADP american_scientific_journal-3226 244 5 the the DET american_scientific_journal-3226 244 6 p53 p53 NOUN american_scientific_journal-3226 244 7 gene gene NOUN american_scientific_journal-3226 244 8 . . PUNCT american_scientific_journal-3226 244 9 ” " PUNCT american_scientific_journal-3226 245 1 annual annual ADJ american_scientific_journal-3226 245 2 review review NOUN american_scientific_journal-3226 245 3 of of ADP american_scientific_journal-3226 245 4 medicine medicine NOUN american_scientific_journal-3226 245 5 , , PUNCT american_scientific_journal-3226 245 6 vol vol NOUN american_scientific_journal-3226 245 7 . . PROPN american_scientific_journal-3226 246 1 47 47 NUM american_scientific_journal-3226 246 2 , , PUNCT american_scientific_journal-3226 246 3 pp pp ADJ american_scientific_journal-3226 246 4 . . PUNCT american_scientific_journal-3226 247 1 285 285 NUM american_scientific_journal-3226 247 2 - - SYM american_scientific_journal-3226 247 3 301 301 NUM american_scientific_journal-3226 247 4 . . PUNCT american_scientific_journal-3226 247 5 1996 1996 NUM american_scientific_journal-3226 247 6 . . PUNCT american_scientific_journal-3226 248 1 [ [ X american_scientific_journal-3226 248 2 30 30 NUM american_scientific_journal-3226 248 3 ] ] PUNCT american_scientific_journal-3226 248 4 . . PUNCT american_scientific_journal-3226 249 1 ja ja PROPN american_scientific_journal-3226 249 2 blondal blondal PROPN american_scientific_journal-3226 249 3 and and CCONJ american_scientific_journal-3226 249 4 s s PROPN american_scientific_journal-3226 249 5 benchimol benchimol NOUN american_scientific_journal-3226 249 6 . . PUNCT american_scientific_journal-3226 250 1 “ " PUNCT american_scientific_journal-3226 250 2 the the DET american_scientific_journal-3226 250 3 role role NOUN american_scientific_journal-3226 250 4 of of ADP american_scientific_journal-3226 250 5 p53 p53 NOUN american_scientific_journal-3226 250 6 in in ADP american_scientific_journal-3226 250 7 tumor tumor NOUN american_scientific_journal-3226 250 8 progression progression NOUN american_scientific_journal-3226 250 9 . . PUNCT american_scientific_journal-3226 250 10 ” " PUNCT american_scientific_journal-3226 251 1 semin semin PROPN american_scientific_journal-3226 251 2 cancer cancer PROPN american_scientific_journal-3226 251 3 biol biol PROPN american_scientific_journal-3226 251 4 , , PUNCT american_scientific_journal-3226 251 5 vol vol NOUN american_scientific_journal-3226 251 6 . . PROPN american_scientific_journal-3226 251 7 5 5 NUM american_scientific_journal-3226 251 8 , , PUNCT american_scientific_journal-3226 251 9 pp pp ADJ american_scientific_journal-3226 251 10 . . PUNCT american_scientific_journal-3226 252 1 177 177 NUM american_scientific_journal-3226 252 2 - - SYM american_scientific_journal-3226 252 3 86 86 NUM american_scientific_journal-3226 252 4 . . PUNCT american_scientific_journal-3226 253 1 1994 1994 NUM american_scientific_journal-3226 253 2 . . PUNCT american_scientific_journal-3226 254 1 [ [ X american_scientific_journal-3226 254 2 31 31 NUM american_scientific_journal-3226 254 3 ] ] PUNCT american_scientific_journal-3226 254 4 . . PUNCT american_scientific_journal-3226 255 1 mra mra PROPN american_scientific_journal-3226 255 2 mowat mowat PROPN american_scientific_journal-3226 255 3 . . PUNCT american_scientific_journal-3226 256 1 “ " PUNCT american_scientific_journal-3226 256 2 p53 p53 NOUN american_scientific_journal-3226 256 3 in in ADP american_scientific_journal-3226 256 4 tumor tumor NOUN american_scientific_journal-3226 256 5 progression progression NOUN american_scientific_journal-3226 256 6 : : PUNCT american_scientific_journal-3226 256 7 life life NOUN american_scientific_journal-3226 256 8 , , PUNCT american_scientific_journal-3226 256 9 death death NOUN american_scientific_journal-3226 256 10 , , PUNCT american_scientific_journal-3226 256 11 and and CCONJ american_scientific_journal-3226 256 12 everything everything PRON american_scientific_journal-3226 256 13 . . PUNCT american_scientific_journal-3226 256 14 ” " PUNCT american_scientific_journal-3226 257 1 advanced advanced ADJ american_scientific_journal-3226 257 2 cancer cancer NOUN american_scientific_journal-3226 257 3 research research NOUN american_scientific_journal-3226 257 4 , , PUNCT american_scientific_journal-3226 257 5 vol vol NOUN american_scientific_journal-3226 257 6 . . PROPN american_scientific_journal-3226 258 1 74 74 NUM american_scientific_journal-3226 258 2 , , PUNCT american_scientific_journal-3226 258 3 pp pp ADJ american_scientific_journal-3226 258 4 . . PUNCT american_scientific_journal-3226 259 1 25 25 NUM american_scientific_journal-3226 259 2 - - SYM american_scientific_journal-3226 259 3 48 48 NUM american_scientific_journal-3226 259 4 . . PUNCT american_scientific_journal-3226 260 1 1998 1998 NUM american_scientific_journal-3226 260 2 . . PUNCT american_scientific_journal-3226 261 1 [ [ X american_scientific_journal-3226 261 2 32 32 NUM american_scientific_journal-3226 261 3 ] ] PUNCT american_scientific_journal-3226 261 4 . . PUNCT american_scientific_journal-3226 262 1 ma ma PROPN american_scientific_journal-3226 262 2 kuczyk kuczyk PROPN american_scientific_journal-3226 262 3 , , PUNCT american_scientific_journal-3226 262 4 j j PROPN american_scientific_journal-3226 262 5 serth serth NOUN american_scientific_journal-3226 262 6 , , PUNCT american_scientific_journal-3226 262 7 c c PROPN american_scientific_journal-3226 262 8 bokemeyer bokemeyer X american_scientific_journal-3226 262 9 , , PUNCT american_scientific_journal-3226 262 10 s s VERB american_scientific_journal-3226 262 11 machtens machten NOUN american_scientific_journal-3226 262 12 , , PUNCT american_scientific_journal-3226 262 13 a a DET american_scientific_journal-3226 262 14 minssen minssen PROPN american_scientific_journal-3226 262 15 , , PUNCT american_scientific_journal-3226 262 16 w w NOUN american_scientific_journal-3226 262 17 bathke bathke PROPN american_scientific_journal-3226 262 18 , , PUNCT american_scientific_journal-3226 262 19 j j PROPN american_scientific_journal-3226 262 20 hartmann hartmann PROPN american_scientific_journal-3226 262 21 , , PUNCT american_scientific_journal-3226 262 22 and and CCONJ american_scientific_journal-3226 262 23 u u PROPN american_scientific_journal-3226 262 24 jonas jonas PROPN american_scientific_journal-3226 262 25 . . PUNCT american_scientific_journal-3226 263 1 “ " PUNCT american_scientific_journal-3226 263 2 the the DET american_scientific_journal-3226 263 3 prognostic prognostic ADJ american_scientific_journal-3226 263 4 value value NOUN american_scientific_journal-3226 263 5 of of ADP american_scientific_journal-3226 263 6 p53 p53 NOUN american_scientific_journal-3226 263 7 for for ADP american_scientific_journal-3226 263 8 long long ADJ american_scientific_journal-3226 263 9 - - PUNCT american_scientific_journal-3226 263 10 term term NOUN american_scientific_journal-3226 263 11 and and CCONJ american_scientific_journal-3226 263 12 recurrence recurrence NOUN american_scientific_journal-3226 263 13 - - PUNCT american_scientific_journal-3226 263 14 free free ADJ american_scientific_journal-3226 263 15 survival survival NOUN american_scientific_journal-3226 263 16 following follow VERB american_scientific_journal-3226 263 17 radical radical ADJ american_scientific_journal-3226 263 18 prostatectomy prostatectomy NOUN american_scientific_journal-3226 263 19 . . PUNCT american_scientific_journal-3226 263 20 ” " PUNCT american_scientific_journal-3226 264 1 eur eur PROPN american_scientific_journal-3226 264 2 j j PROPN american_scientific_journal-3226 264 3 cancer cancer NOUN american_scientific_journal-3226 264 4 , , PUNCT american_scientific_journal-3226 264 5 vol vol NOUN american_scientific_journal-3226 264 6 . . PROPN american_scientific_journal-3226 264 7 34 34 NUM american_scientific_journal-3226 264 8 , , PUNCT american_scientific_journal-3226 264 9 pp pp ADJ american_scientific_journal-3226 264 10 . . PUNCT american_scientific_journal-3226 264 11 679 679 NUM american_scientific_journal-3226 264 12 - - SYM american_scientific_journal-3226 264 13 86 86 NUM american_scientific_journal-3226 264 14 . . PUNCT american_scientific_journal-3226 264 15 1998 1998 NUM american_scientific_journal-3226 264 16 . . PUNCT