id	sid	tid	token	lemma	pos
amwa-142	1	1	34	34	NUM
amwa-142	1	2	amwa	amwa	PROPN
amwa-142	1	3	journal	journal	PROPN
amwa-142	1	4	/	/	SYM
amwa-142	1	5	v36	v36	PROPN
amwa-142	1	6	n1	n1	PROPN
amwa-142	1	7	/	/	SYM
amwa-142	1	8	2021	2021	NUM
amwa-142	1	9	/	/	SYM
amwa-142	1	10	amwa.org	amwa.org	NOUN
amwa-142	1	11	efficacy	efficacy	NOUN
amwa-142	1	12	and	and	CCONJ
amwa-142	1	13	effectiveness	effectiveness	NOUN
amwa-142	1	14	in	in	ADP
amwa-142	1	15	our	our	PRON
amwa-142	1	16	previous	previous	ADJ
amwa-142	1	17	article	article	NOUN
amwa-142	1	18	(	(	PUNCT
amwa-142	1	19	schindler	schindler	PROPN
amwa-142	1	20	tm	tm	PROPN
amwa-142	1	21	,	,	PUNCT
amwa-142	1	22	bridge	bridge	PROPN
amwa-142	1	23	h.	h.	PROPN
amwa-142	1	24	the	the	DET
amwa-142	1	25	evaluation	evaluation	NOUN
amwa-142	1	26	of	of	ADP
amwa-142	1	27	efficacy	efficacy	NOUN
amwa-142	1	28	,	,	PUNCT
amwa-142	1	29	or	or	CCONJ
amwa-142	1	30	how	how	SCONJ
amwa-142	1	31	do	do	AUX
amwa-142	1	32	we	we	PRON
amwa-142	1	33	know	know	VERB
amwa-142	1	34	whether	whether	SCONJ
amwa-142	1	35	a	a	DET
amwa-142	1	36	treatment	treatment	NOUN
amwa-142	1	37	works	work	VERB
amwa-142	1	38	?	?	PUNCT
amwa-142	2	1	part	part	NOUN
amwa-142	2	2	1	1	NUM
amwa-142	2	3	.	.	PUNCT
amwa-142	2	4	amwa	amwa	PROPN
amwa-142	2	5	j.	j.	PROPN
amwa-142	2	6	2020;35(2):82	2020;35(2):82	PROPN
amwa-142	2	7	-	-	SYM
amwa-142	2	8	86	86	NUM
amwa-142	2	9	)	)	PUNCT
amwa-142	3	1	,	,	PUNCT
amwa-142	3	2	we	we	PRON
amwa-142	3	3	described	describe	VERB
amwa-142	3	4	how	how	SCONJ
amwa-142	3	5	randomized	randomized	ADJ
amwa-142	3	6	clinical	clinical	ADJ
amwa-142	3	7	trials	trial	NOUN
amwa-142	3	8	(	(	PUNCT
amwa-142	3	9	rcts	rct	NOUN
amwa-142	3	10	)	)	PUNCT
amwa-142	3	11	determine	determine	VERB
amwa-142	3	12	efficacy	efficacy	NOUN
amwa-142	3	13	of	of	ADP
amwa-142	3	14	a	a	DET
amwa-142	3	15	treatment	treatment	NOUN
amwa-142	3	16	.	.	PUNCT
amwa-142	4	1	efficacy	efficacy	NOUN
amwa-142	4	2	is	be	AUX
amwa-142	4	3	generally	generally	ADV
amwa-142	4	4	understood	understand	VERB
amwa-142	4	5	as	as	ADP
amwa-142	4	6	the	the	DET
amwa-142	4	7	ability	ability	NOUN
amwa-142	4	8	of	of	ADP
amwa-142	4	9	a	a	DET
amwa-142	4	10	drug	drug	NOUN
amwa-142	4	11	or	or	CCONJ
amwa-142	4	12	other	other	ADJ
amwa-142	4	13	intervention	intervention	NOUN
amwa-142	4	14	to	to	PART
amwa-142	4	15	reliably	reliably	ADV
amwa-142	4	16	produce	produce	VERB
amwa-142	4	17	a	a	DET
amwa-142	4	18	positive	positive	ADJ
amwa-142	4	19	effect	effect	NOUN
amwa-142	4	20	in	in	ADP
amwa-142	4	21	patients	patient	NOUN
amwa-142	4	22	with	with	ADP
amwa-142	4	23	a	a	DET
amwa-142	4	24	defined	define	VERB
amwa-142	4	25	disease	disease	NOUN
amwa-142	4	26	under	under	ADP
amwa-142	4	27	controlled	control	VERB
amwa-142	4	28	conditions	condition	NOUN
amwa-142	4	29	.	.	PUNCT
amwa-142	5	1	in	in	ADP
amwa-142	5	2	other	other	ADJ
amwa-142	5	3	words	word	NOUN
amwa-142	5	4	,	,	PUNCT
amwa-142	5	5	clinical	clinical	ADJ
amwa-142	5	6	trials	trial	NOUN
amwa-142	5	7	are	be	AUX
amwa-142	5	8	good	good	ADJ
amwa-142	5	9	tools	tool	NOUN
amwa-142	5	10	to	to	PART
amwa-142	5	11	evaluate	evaluate	VERB
amwa-142	5	12	efficacy	efficacy	NOUN
amwa-142	5	13	.	.	PUNCT
amwa-142	6	1	clinical	clinical	ADJ
amwa-142	6	2	trials	trial	NOUN
amwa-142	6	3	provide	provide	VERB
amwa-142	6	4	a	a	DET
amwa-142	6	5	well	well	ADV
amwa-142	6	6	-	-	PUNCT
amwa-142	6	7	controlled	control	VERB
amwa-142	6	8	framework	framework	NOUN
amwa-142	6	9	that	that	PRON
amwa-142	6	10	is	be	AUX
amwa-142	6	11	characterized	characterize	VERB
amwa-142	6	12	by	by	ADP
amwa-142	6	13	the	the	DET
amwa-142	6	14	following	following	NOUN
amwa-142	6	15	:	:	PUNCT
amwa-142	6	16	•	•	NUM
amwa-142	6	17	selecting	select	VERB
amwa-142	6	18	participants	participant	NOUN
amwa-142	6	19	according	accord	VERB
amwa-142	6	20	to	to	ADP
amwa-142	6	21	clearly	clearly	ADV
amwa-142	6	22	defined	define	VERB
amwa-142	6	23	eligibility	eligibility	NOUN
amwa-142	6	24	criteria	criterion	NOUN
amwa-142	6	25	•	•	ADV
amwa-142	6	26	randomly	randomly	ADV
amwa-142	6	27	allocating	allocate	VERB
amwa-142	6	28	participants	participant	NOUN
amwa-142	6	29	to	to	ADP
amwa-142	6	30	treatment	treatment	NOUN
amwa-142	6	31	groups	group	NOUN
amwa-142	6	32	•	•	ADV
amwa-142	6	33	concealing	conceal	VERB
amwa-142	6	34	study	study	NOUN
amwa-142	6	35	treatments	treatment	NOUN
amwa-142	6	36	to	to	ADP
amwa-142	6	37	participants	participant	NOUN
amwa-142	6	38	and	and	CCONJ
amwa-142	6	39	study	study	VERB
amwa-142	6	40	doctors	doctor	NOUN
amwa-142	6	41	(	(	PUNCT
amwa-142	6	42	blinding	blind	VERB
amwa-142	6	43	)	)	PUNCT
amwa-142	6	44	•	•	ADP
amwa-142	6	45	clearly	clearly	ADV
amwa-142	6	46	defining	define	VERB
amwa-142	6	47	endpoint	endpoint	NOUN
amwa-142	6	48	measures	measure	NOUN
amwa-142	6	49	before	before	SCONJ
amwa-142	6	50	study	study	NOUN
amwa-142	6	51	start	start	NOUN
amwa-142	6	52	provided	provide	VERB
amwa-142	6	53	a	a	DET
amwa-142	6	54	drug	drug	NOUN
amwa-142	6	55	consistently	consistently	ADV
amwa-142	6	56	demonstrates	demonstrate	VERB
amwa-142	6	57	efficacy	efficacy	NOUN
amwa-142	6	58	in	in	ADP
amwa-142	6	59	several	several	ADJ
amwa-142	6	60	clinical	clinical	ADJ
amwa-142	6	61	studies	study	NOUN
amwa-142	6	62	and	and	CCONJ
amwa-142	6	63	appears	appear	VERB
amwa-142	6	64	safe	safe	ADJ
amwa-142	6	65	,	,	PUNCT
amwa-142	6	66	regulators	regulator	NOUN
amwa-142	6	67	will	will	AUX
amwa-142	6	68	approve	approve	VERB
amwa-142	6	69	it	it	PRON
amwa-142	6	70	and	and	CCONJ
amwa-142	6	71	permit	permit	VERB
amwa-142	6	72	its	its	PRON
amwa-142	6	73	marketing	marketing	NOUN
amwa-142	6	74	for	for	ADP
amwa-142	6	75	the	the	DET
amwa-142	6	76	treatment	treatment	NOUN
amwa-142	6	77	of	of	ADP
amwa-142	6	78	a	a	DET
amwa-142	6	79	disease	disease	NOUN
amwa-142	6	80	.	.	PUNCT
amwa-142	7	1	however	however	ADV
amwa-142	7	2	,	,	PUNCT
amwa-142	7	3	once	once	ADV
amwa-142	7	4	a	a	DET
amwa-142	7	5	drug	drug	NOUN
amwa-142	7	6	is	be	AUX
amwa-142	7	7	on	on	ADP
amwa-142	7	8	the	the	DET
amwa-142	7	9	market	market	NOUN
amwa-142	7	10	,	,	PUNCT
amwa-142	7	11	it	it	PRON
amwa-142	7	12	will	will	AUX
amwa-142	7	13	be	be	AUX
amwa-142	7	14	used	use	VERB
amwa-142	7	15	for	for	ADP
amwa-142	7	16	the	the	DET
amwa-142	7	17	entire	entire	ADJ
amwa-142	7	18	spectrum	spectrum	NOUN
amwa-142	7	19	of	of	ADP
amwa-142	7	20	patients	patient	NOUN
amwa-142	7	21	and	and	CCONJ
amwa-142	7	22	under	under	ADP
amwa-142	7	23	circumstances	circumstance	NOUN
amwa-142	7	24	that	that	PRON
amwa-142	7	25	might	might	AUX
amwa-142	7	26	not	not	PART
amwa-142	7	27	have	have	AUX
amwa-142	7	28	been	be	AUX
amwa-142	7	29	tested	test	VERB
amwa-142	7	30	in	in	ADP
amwa-142	7	31	the	the	DET
amwa-142	7	32	clinical	clinical	ADJ
amwa-142	7	33	studies	study	NOUN
amwa-142	7	34	.	.	PUNCT
amwa-142	8	1	for	for	ADP
amwa-142	8	2	example	example	NOUN
amwa-142	8	3	,	,	PUNCT
amwa-142	8	4	the	the	DET
amwa-142	8	5	new	new	ADJ
amwa-142	8	6	drug	drug	NOUN
amwa-142	8	7	will	will	AUX
amwa-142	8	8	be	be	AUX
amwa-142	8	9	used	use	VERB
amwa-142	8	10	in	in	ADP
amwa-142	8	11	patients	patient	NOUN
amwa-142	8	12	who	who	PRON
amwa-142	8	13	have	have	VERB
amwa-142	8	14	several	several	ADJ
amwa-142	8	15	comorbidities	comorbiditie	NOUN
amwa-142	8	16	in	in	ADP
amwa-142	8	17	addition	addition	NOUN
amwa-142	8	18	to	to	ADP
amwa-142	8	19	the	the	DET
amwa-142	8	20	approved	approve	VERB
amwa-142	8	21	indication	indication	NOUN
amwa-142	8	22	.	.	PUNCT
amwa-142	9	1	the	the	DET
amwa-142	9	2	evaluation	evaluation	NOUN
amwa-142	9	3	of	of	ADP
amwa-142	9	4	a	a	DET
amwa-142	9	5	drug	drug	NOUN
amwa-142	9	6	’s	’s	PART
amwa-142	9	7	effects	effect	NOUN
amwa-142	9	8	under	under	ADP
amwa-142	9	9	everyday	everyday	ADJ
amwa-142	9	10	conditions	condition	NOUN
amwa-142	9	11	is	be	AUX
amwa-142	9	12	called	call	VERB
amwa-142	9	13	effectiveness	effectiveness	NOUN
amwa-142	9	14	research	research	NOUN
amwa-142	9	15	.	.	PUNCT
amwa-142	10	1	why	why	SCONJ
amwa-142	10	2	does	do	AUX
amwa-142	10	3	a	a	DET
amwa-142	10	4	treatment	treatment	NOUN
amwa-142	10	5	’s	’s	PART
amwa-142	10	6	effectiveness	effectiveness	NOUN
amwa-142	10	7	differ	differ	VERB
amwa-142	10	8	from	from	ADP
amwa-142	10	9	its	its	PRON
amwa-142	10	10	efficacy	efficacy	NOUN
amwa-142	10	11	?	?	PUNCT
amwa-142	11	1	there	there	PRON
amwa-142	11	2	are	be	VERB
amwa-142	11	3	many	many	ADJ
amwa-142	11	4	reasons	reason	NOUN
amwa-142	11	5	why	why	SCONJ
amwa-142	11	6	the	the	DET
amwa-142	11	7	effects	effect	NOUN
amwa-142	11	8	of	of	ADP
amwa-142	11	9	a	a	DET
amwa-142	11	10	drug	drug	NOUN
amwa-142	11	11	in	in	ADP
amwa-142	11	12	everyday	everyday	ADJ
amwa-142	11	13	clinical	clinical	ADJ
amwa-142	11	14	practice	practice	NOUN
amwa-142	11	15	are	be	AUX
amwa-142	11	16	different	different	ADJ
amwa-142	11	17	from	from	ADP
amwa-142	11	18	those	those	PRON
amwa-142	11	19	seen	see	VERB
amwa-142	11	20	in	in	ADP
amwa-142	11	21	clinical	clinical	ADJ
amwa-142	11	22	trials	trial	NOUN
amwa-142	11	23	.	.	PUNCT
amwa-142	12	1	in	in	ADP
amwa-142	12	2	short	short	ADJ
amwa-142	12	3	,	,	PUNCT
amwa-142	12	4	the	the	DET
amwa-142	12	5	entire	entire	ADJ
amwa-142	12	6	societal	societal	ADJ
amwa-142	12	7	-	-	PUNCT
amwa-142	12	8	medical	medical	ADJ
amwa-142	12	9	context	context	NOUN
amwa-142	12	10	contributes	contribute	VERB
amwa-142	12	11	to	to	ADP
amwa-142	12	12	the	the	DET
amwa-142	12	13	effectiveness	effectiveness	NOUN
amwa-142	12	14	of	of	ADP
amwa-142	12	15	a	a	DET
amwa-142	12	16	drug	drug	NOUN
amwa-142	12	17	or	or	CCONJ
amwa-142	12	18	intervention	intervention	NOUN
amwa-142	12	19	.	.	PUNCT
amwa-142	13	1	before	before	SCONJ
amwa-142	13	2	we	we	PRON
amwa-142	13	3	look	look	VERB
amwa-142	13	4	at	at	ADP
amwa-142	13	5	some	some	PRON
amwa-142	13	6	of	of	ADP
amwa-142	13	7	the	the	DET
amwa-142	13	8	key	key	ADJ
amwa-142	13	9	factors	factor	NOUN
amwa-142	13	10	,	,	PUNCT
amwa-142	13	11	we	we	PRON
amwa-142	13	12	need	need	VERB
amwa-142	13	13	to	to	PART
amwa-142	13	14	remind	remind	VERB
amwa-142	13	15	ourselves	ourselves	PRON
amwa-142	13	16	that	that	SCONJ
amwa-142	13	17	both	both	DET
amwa-142	13	18	“	"	PUNCT
amwa-142	13	19	efficacy	efficacy	NOUN
amwa-142	13	20	”	"	PUNCT
amwa-142	13	21	and	and	CCONJ
amwa-142	13	22	“	"	PUNCT
amwa-142	13	23	effectiveness	effectiveness	NOUN
amwa-142	13	24	”	"	PUNCT
amwa-142	13	25	are	be	AUX
amwa-142	13	26	determined	determine	VERB
amwa-142	13	27	in	in	ADP
amwa-142	13	28	groups	group	NOUN
amwa-142	13	29	of	of	ADP
amwa-142	13	30	people	people	NOUN
amwa-142	13	31	and	and	CCONJ
amwa-142	13	32	not	not	PART
amwa-142	13	33	individuals	individual	NOUN
amwa-142	13	34	.	.	PUNCT
amwa-142	14	1	while	while	SCONJ
amwa-142	14	2	efficacy	efficacy	NOUN
amwa-142	14	3	pertains	pertain	VERB
amwa-142	14	4	to	to	ADP
amwa-142	14	5	groups	group	NOUN
amwa-142	14	6	of	of	ADP
amwa-142	14	7	participants	participant	NOUN
amwa-142	14	8	in	in	ADP
amwa-142	14	9	clinical	clinical	ADJ
amwa-142	14	10	trials	trial	NOUN
amwa-142	14	11	,	,	PUNCT
amwa-142	14	12	effectiveness	effectiveness	NOUN
amwa-142	14	13	pertains	pertain	VERB
amwa-142	14	14	to	to	ADP
amwa-142	14	15	all	all	DET
amwa-142	14	16	people	people	NOUN
amwa-142	14	17	with	with	ADP
amwa-142	14	18	a	a	DET
amwa-142	14	19	disease	disease	NOUN
amwa-142	14	20	who	who	PRON
amwa-142	14	21	could	could	AUX
amwa-142	14	22	be	be	AUX
amwa-142	14	23	treated	treat	VERB
amwa-142	14	24	with	with	ADP
amwa-142	14	25	the	the	DET
amwa-142	14	26	drug	drug	NOUN
amwa-142	14	27	.	.	PUNCT
amwa-142	15	1	issue	issue	NOUN
amwa-142	15	2	1	1	NUM
amwa-142	15	3	:	:	PUNCT
amwa-142	15	4	physical	physical	ADJ
amwa-142	15	5	availability	availability	NOUN
amwa-142	15	6	and	and	CCONJ
amwa-142	15	7	accessibility	accessibility	NOUN
amwa-142	15	8	above	above	ADP
amwa-142	15	9	all	all	DET
amwa-142	15	10	else	else	ADV
amwa-142	15	11	,	,	PUNCT
amwa-142	15	12	to	to	PART
amwa-142	15	13	be	be	AUX
amwa-142	15	14	effective	effective	ADJ
amwa-142	15	15	,	,	PUNCT
amwa-142	15	16	a	a	DET
amwa-142	15	17	drug	drug	NOUN
amwa-142	15	18	needs	need	VERB
amwa-142	15	19	to	to	PART
amwa-142	15	20	be	be	AUX
amwa-142	15	21	available	available	ADJ
amwa-142	15	22	to	to	ADP
amwa-142	15	23	patients	patient	NOUN
amwa-142	15	24	,	,	PUNCT
amwa-142	15	25	at	at	ADP
amwa-142	15	26	best	good	ADJ
amwa-142	15	27	to	to	ADP
amwa-142	15	28	all	all	DET
amwa-142	15	29	patients	patient	NOUN
amwa-142	15	30	with	with	ADP
amwa-142	15	31	the	the	DET
amwa-142	15	32	disease	disease	NOUN
amwa-142	15	33	it	it	PRON
amwa-142	15	34	was	be	AUX
amwa-142	15	35	developed	develop	VERB
amwa-142	15	36	to	to	PART
amwa-142	15	37	treat	treat	VERB
amwa-142	15	38	.	.	PUNCT
amwa-142	16	1	there	there	PRON
amwa-142	16	2	are	be	VERB
amwa-142	16	3	national	national	ADJ
amwa-142	16	4	,	,	PUNCT
amwa-142	16	5	regional	regional	ADJ
amwa-142	16	6	,	,	PUNCT
amwa-142	16	7	and	and	CCONJ
amwa-142	16	8	local	local	ADJ
amwa-142	16	9	aspects	aspect	NOUN
amwa-142	16	10	of	of	ADP
amwa-142	16	11	availability	availability	NOUN
amwa-142	16	12	of	of	ADP
amwa-142	16	13	a	a	DET
amwa-142	16	14	treatment	treatment	NOUN
amwa-142	16	15	.	.	PUNCT
amwa-142	17	1	approval	approval	NOUN
amwa-142	17	2	of	of	ADP
amwa-142	17	3	a	a	DET
amwa-142	17	4	drug	drug	NOUN
amwa-142	17	5	by	by	ADP
amwa-142	17	6	regulators	regulator	NOUN
amwa-142	17	7	permits	permit	VERB
amwa-142	17	8	its	its	PRON
amwa-142	17	9	marketing	marketing	NOUN
amwa-142	17	10	and	and	CCONJ
amwa-142	17	11	selling	selling	NOUN
amwa-142	17	12	in	in	ADP
amwa-142	17	13	a	a	DET
amwa-142	17	14	certain	certain	ADJ
amwa-142	17	15	country	country	NOUN
amwa-142	17	16	.	.	PUNCT
amwa-142	18	1	for	for	ADP
amwa-142	18	2	example	example	NOUN
amwa-142	18	3	,	,	PUNCT
amwa-142	18	4	a	a	DET
amwa-142	18	5	drug	drug	NOUN
amwa-142	18	6	that	that	PRON
amwa-142	18	7	is	be	AUX
amwa-142	18	8	approved	approve	VERB
amwa-142	18	9	in	in	ADP
amwa-142	18	10	the	the	DET
amwa-142	18	11	united	united	PROPN
amwa-142	18	12	states	states	PROPN
amwa-142	18	13	may	may	AUX
amwa-142	18	14	not	not	PART
amwa-142	18	15	be	be	AUX
amwa-142	18	16	available	available	ADJ
amwa-142	18	17	in	in	ADP
amwa-142	18	18	canada	canada	PROPN
amwa-142	18	19	or	or	CCONJ
amwa-142	18	20	mexico	mexico	PROPN
amwa-142	18	21	.	.	PUNCT
amwa-142	19	1	before	before	SCONJ
amwa-142	19	2	the	the	DET
amwa-142	19	3	new	new	ADJ
amwa-142	19	4	drug	drug	NOUN
amwa-142	19	5	reaches	reach	VERB
amwa-142	19	6	a	a	DET
amwa-142	19	7	patient	patient	NOUN
amwa-142	19	8	,	,	PUNCT
amwa-142	19	9	a	a	DET
amwa-142	19	10	number	number	NOUN
amwa-142	19	11	of	of	ADP
amwa-142	19	12	obstacles	obstacle	NOUN
amwa-142	19	13	in	in	ADP
amwa-142	19	14	the	the	DET
amwa-142	19	15	supply	supply	NOUN
amwa-142	19	16	chain	chain	NOUN
amwa-142	19	17	need	need	VERB
amwa-142	19	18	to	to	PART
amwa-142	19	19	be	be	AUX
amwa-142	19	20	overcome	overcome	VERB
amwa-142	19	21	.	.	PUNCT
amwa-142	20	1	the	the	DET
amwa-142	20	2	first	first	ADJ
amwa-142	20	3	one	one	NOUN
amwa-142	20	4	is	be	AUX
amwa-142	20	5	reimbursement	reimbursement	NOUN
amwa-142	20	6	,	,	PUNCT
amwa-142	20	7	ie	ie	X
amwa-142	20	8	,	,	PUNCT
amwa-142	20	9	the	the	DET
amwa-142	20	10	negotiation	negotiation	NOUN
amwa-142	20	11	of	of	ADP
amwa-142	20	12	price	price	NOUN
amwa-142	20	13	for	for	ADP
amwa-142	20	14	the	the	DET
amwa-142	20	15	new	new	ADJ
amwa-142	20	16	drug	drug	NOUN
amwa-142	20	17	with	with	ADP
amwa-142	20	18	government	government	NOUN
amwa-142	20	19	agencies	agency	NOUN
amwa-142	20	20	,	,	PUNCT
amwa-142	20	21	insurance	insurance	NOUN
amwa-142	20	22	companies	company	NOUN
amwa-142	20	23	,	,	PUNCT
amwa-142	20	24	and	and	CCONJ
amwa-142	20	25	pharma	pharma	PROPN
amwa-142	20	26	wholesalers	wholesaler	NOUN
amwa-142	20	27	.	.	PUNCT
amwa-142	21	1	discussions	discussion	NOUN
amwa-142	21	2	on	on	ADP
amwa-142	21	3	price	price	NOUN
amwa-142	21	4	may	may	AUX
amwa-142	21	5	have	have	VERB
amwa-142	21	6	a	a	DET
amwa-142	21	7	drastic	drastic	ADJ
amwa-142	21	8	effect	effect	NOUN
amwa-142	21	9	on	on	ADP
amwa-142	21	10	availability	availability	NOUN
amwa-142	21	11	.	.	PUNCT
amwa-142	22	1	if	if	SCONJ
amwa-142	22	2	a	a	DET
amwa-142	22	3	pharmaceutical	pharmaceutical	ADJ
amwa-142	22	4	company	company	NOUN
amwa-142	22	5	considers	consider	VERB
amwa-142	22	6	the	the	DET
amwa-142	22	7	proposed	propose	VERB
amwa-142	22	8	price	price	NOUN
amwa-142	22	9	too	too	ADV
amwa-142	22	10	low	low	ADJ
amwa-142	22	11	to	to	PART
amwa-142	22	12	ever	ever	ADV
amwa-142	22	13	regain	regain	VERB
amwa-142	22	14	its	its	PRON
amwa-142	22	15	investments	investment	NOUN
amwa-142	22	16	,	,	PUNCT
amwa-142	22	17	it	it	PRON
amwa-142	22	18	may	may	AUX
amwa-142	22	19	decide	decide	VERB
amwa-142	22	20	not	not	PART
amwa-142	22	21	to	to	PART
amwa-142	22	22	provide	provide	VERB
amwa-142	22	23	the	the	DET
amwa-142	22	24	drug	drug	NOUN
amwa-142	22	25	at	at	ADV
amwa-142	22	26	all	all	ADV
amwa-142	22	27	.	.	PUNCT
amwa-142	23	1	regional	regional	ADJ
amwa-142	23	2	differences	difference	NOUN
amwa-142	23	3	in	in	ADP
amwa-142	23	4	availability	availability	NOUN
amwa-142	23	5	may	may	AUX
amwa-142	23	6	arise	arise	VERB
amwa-142	23	7	when	when	SCONJ
amwa-142	23	8	regional	regional	ADJ
amwa-142	23	9	pharma	pharma	PROPN
amwa-142	23	10	wholesale	wholesale	ADJ
amwa-142	23	11	companies	company	NOUN
amwa-142	23	12	decide	decide	VERB
amwa-142	23	13	on	on	ADP
amwa-142	23	14	stocking	stocking	NOUN
amwa-142	23	15	of	of	ADP
amwa-142	23	16	medicines	medicine	NOUN
amwa-142	23	17	.	.	PUNCT
amwa-142	24	1	they	they	PRON
amwa-142	24	2	may	may	AUX
amwa-142	24	3	decide	decide	VERB
amwa-142	24	4	not	not	PART
amwa-142	24	5	to	to	PART
amwa-142	24	6	stock	stock	VERB
amwa-142	24	7	a	a	DET
amwa-142	24	8	certain	certain	ADJ
amwa-142	24	9	drug	drug	NOUN
amwa-142	24	10	in	in	ADP
amwa-142	24	11	certain	certain	ADJ
amwa-142	24	12	locations	location	NOUN
amwa-142	24	13	because	because	SCONJ
amwa-142	24	14	they	they	PRON
amwa-142	24	15	do	do	AUX
amwa-142	24	16	not	not	PART
amwa-142	24	17	believe	believe	VERB
amwa-142	24	18	that	that	SCONJ
amwa-142	24	19	it	it	PRON
amwa-142	24	20	will	will	AUX
amwa-142	24	21	be	be	AUX
amwa-142	24	22	widely	widely	ADV
amwa-142	24	23	used	use	VERB
amwa-142	24	24	there	there	ADV
amwa-142	24	25	.	.	PUNCT
amwa-142	25	1	even	even	ADV
amwa-142	25	2	if	if	SCONJ
amwa-142	25	3	a	a	DET
amwa-142	25	4	drug	drug	NOUN
amwa-142	25	5	is	be	AUX
amwa-142	25	6	available	available	ADJ
amwa-142	25	7	via	via	ADP
amwa-142	25	8	a	a	DET
amwa-142	25	9	wholesaler	wholesaler	NOUN
amwa-142	25	10	and	and	CCONJ
amwa-142	25	11	the	the	DET
amwa-142	25	12	physician	physician	NOUN
amwa-142	25	13	is	be	AUX
amwa-142	25	14	willing	willing	ADJ
amwa-142	25	15	to	to	PART
amwa-142	25	16	prescribe	prescribe	VERB
amwa-142	25	17	it	it	PRON
amwa-142	25	18	,	,	PUNCT
amwa-142	25	19	a	a	DET
amwa-142	25	20	patient	patient	NOUN
amwa-142	25	21	’s	’s	PART
amwa-142	25	22	health	health	NOUN
amwa-142	25	23	insurance	insurance	NOUN
amwa-142	25	24	plan	plan	NOUN
amwa-142	25	25	may	may	AUX
amwa-142	25	26	not	not	PART
amwa-142	25	27	cover	cover	VERB
amwa-142	25	28	the	the	DET
amwa-142	25	29	entire	entire	ADJ
amwa-142	25	30	cost	cost	NOUN
amwa-142	25	31	for	for	ADP
amwa-142	25	32	the	the	DET
amwa-142	25	33	new	new	ADJ
amwa-142	25	34	treatment	treatment	NOUN
amwa-142	25	35	.	.	PUNCT
amwa-142	26	1	likewise	likewise	ADV
amwa-142	26	2	,	,	PUNCT
amwa-142	26	3	if	if	SCONJ
amwa-142	26	4	a	a	DET
amwa-142	26	5	patient	patient	NOUN
amwa-142	26	6	is	be	AUX
amwa-142	26	7	in	in	ADP
amwa-142	26	8	hospital	hospital	NOUN
amwa-142	26	9	,	,	PUNCT
amwa-142	26	10	she	she	PRON
amwa-142	26	11	might	might	AUX
amwa-142	26	12	not	not	PART
amwa-142	26	13	get	get	VERB
amwa-142	26	14	the	the	DET
amwa-142	26	15	drug	drug	NOUN
amwa-142	26	16	because	because	SCONJ
amwa-142	26	17	the	the	DET
amwa-142	26	18	company	company	NOUN
amwa-142	26	19	that	that	PRON
amwa-142	26	20	runs	run	VERB
amwa-142	26	21	the	the	DET
amwa-142	26	22	hospital	hospital	NOUN
amwa-142	26	23	may	may	AUX
amwa-142	26	24	not	not	PART
amwa-142	26	25	see	see	VERB
amwa-142	26	26	its	its	PRON
amwa-142	26	27	benefits	benefit	NOUN
amwa-142	26	28	and	and	CCONJ
amwa-142	26	29	may	may	AUX
amwa-142	26	30	therefore	therefore	ADV
amwa-142	26	31	not	not	PART
amwa-142	26	32	include	include	VERB
amwa-142	26	33	it	it	PRON
amwa-142	26	34	in	in	ADP
amwa-142	26	35	their	their	PRON
amwa-142	26	36	treatment	treatment	NOUN
amwa-142	26	37	plans	plan	NOUN
amwa-142	26	38	and	and	CCONJ
amwa-142	26	39	offer	offer	VERB
amwa-142	26	40	an	an	DET
amwa-142	26	41	alternative	alternative	ADJ
amwa-142	26	42	treatment	treatment	NOUN
amwa-142	26	43	.	.	PUNCT
amwa-142	27	1	furthermore	furthermore	ADV
amwa-142	27	2	,	,	PUNCT
amwa-142	27	3	health	health	NOUN
amwa-142	27	4	care	care	NOUN
amwa-142	27	5	providers	provider	NOUN
amwa-142	27	6	may	may	AUX
amwa-142	27	7	not	not	PART
amwa-142	27	8	believe	believe	VERB
amwa-142	27	9	in	in	ADP
amwa-142	27	10	the	the	DET
amwa-142	27	11	benefits	benefit	NOUN
amwa-142	27	12	of	of	ADP
amwa-142	27	13	a	a	DET
amwa-142	27	14	certain	certain	ADJ
amwa-142	27	15	drug	drug	NOUN
amwa-142	27	16	and	and	CCONJ
amwa-142	27	17	may	may	AUX
amwa-142	27	18	prescribe	prescribe	VERB
amwa-142	27	19	treatments	treatment	NOUN
amwa-142	27	20	that	that	SCONJ
amwa-142	27	21	they	they	PRON
amwa-142	27	22	consider	consider	VERB
amwa-142	27	23	to	to	PART
amwa-142	27	24	have	have	VERB
amwa-142	27	25	superior	superior	ADJ
amwa-142	27	26	therapeutic	therapeutic	ADJ
amwa-142	27	27	effects	effect	NOUN
amwa-142	27	28	instead	instead	ADV
amwa-142	27	29	.	.	PUNCT
amwa-142	28	1	thomas	thomas	PROPN
amwa-142	28	2	m.	m.	PROPN
amwa-142	28	3	schindler1	schindler1	PROPN
amwa-142	28	4	and	and	CCONJ
amwa-142	28	5	helen	helen	PROPN
amwa-142	28	6	bridge2	bridge2	PROPN
amwa-142	28	7	/	/	SYM
amwa-142	29	1	1innovation	1innovation	NUM
amwa-142	29	2	medical	medical	ADJ
amwa-142	29	3	writing	writing	NOUN
amwa-142	29	4	,	,	PUNCT
amwa-142	29	5	boehringer	boehringer	PROPN
amwa-142	29	6	ingelheim	ingelheim	PROPN
amwa-142	29	7	pharma	pharma	PROPN
amwa-142	29	8	,	,	PUNCT
amwa-142	29	9	biberach	biberach	PROPN
amwa-142	29	10	a.d	a.d	PROPN
amwa-142	29	11	.	.	PROPN
amwa-142	29	12	riss	riss	PROPN
amwa-142	29	13	,	,	PUNCT
amwa-142	29	14	germany	germany	PROPN
amwa-142	29	15	;	;	PUNCT
amwa-142	29	16	2medical	2medical	NUM
amwa-142	29	17	communications	communication	NOUN
amwa-142	29	18	,	,	PUNCT
amwa-142	29	19	astrazeneca	astrazeneca	PROPN
amwa-142	29	20	,	,	PUNCT
amwa-142	29	21	cambridge	cambridge	PROPN
amwa-142	29	22	,	,	PUNCT
amwa-142	29	23	united	united	PROPN
amwa-142	29	24	kingdom	kingdom	PROPN
amwa-142	29	25	statistically	statistically	ADV
amwa-142	29	26	speaking	speak	VERB
amwa-142	29	27	the	the	DET
amwa-142	29	28	evaluation	evaluation	NOUN
amwa-142	29	29	of	of	ADP
amwa-142	29	30	effectiveness	effectiveness	NOUN
amwa-142	29	31	,	,	PUNCT
amwa-142	29	32	or	or	CCONJ
amwa-142	29	33	how	how	SCONJ
amwa-142	29	34	do	do	AUX
amwa-142	29	35	we	we	PRON
amwa-142	29	36	know	know	VERB
amwa-142	29	37	whether	whether	SCONJ
amwa-142	29	38	a	a	DET
amwa-142	29	39	treatment	treatment	NOUN
amwa-142	29	40	works	work	VERB
amwa-142	29	41	in	in	ADP
amwa-142	29	42	real	real	ADJ
amwa-142	29	43	life	life	NOUN
amwa-142	29	44	?	?	PUNCT
amwa-142	30	1	part	part	NOUN
amwa-142	30	2	2	2	NUM
amwa-142	30	3	amwa	amwa	PROPN
amwa-142	30	4	journal	journal	PROPN
amwa-142	30	5	/	/	SYM
amwa-142	30	6	v36	v36	PROPN
amwa-142	30	7	n1	n1	PROPN
amwa-142	30	8	/	/	SYM
amwa-142	30	9	2021	2021	NUM
amwa-142	30	10	/	/	SYM
amwa-142	30	11	amwa.org	amwa.org	PROPN
amwa-142	30	12	35	35	NUM
amwa-142	30	13	issue	issue	NOUN
amwa-142	30	14	2	2	NUM
amwa-142	30	15	:	:	PUNCT
amwa-142	30	16	medical	medical	ADJ
amwa-142	30	17	tradition	tradition	NOUN
amwa-142	30	18	medical	medical	ADJ
amwa-142	30	19	doctors	doctor	NOUN
amwa-142	30	20	,	,	PUNCT
amwa-142	30	21	ie	ie	X
amwa-142	30	22	,	,	PUNCT
amwa-142	30	23	the	the	DET
amwa-142	30	24	prescribers	prescriber	NOUN
amwa-142	30	25	of	of	ADP
amwa-142	30	26	medicines	medicine	NOUN
amwa-142	30	27	,	,	PUNCT
amwa-142	30	28	undergo	undergo	VERB
amwa-142	30	29	many	many	ADJ
amwa-142	30	30	years	year	NOUN
amwa-142	30	31	of	of	ADP
amwa-142	30	32	training	training	NOUN
amwa-142	30	33	,	,	PUNCT
amwa-142	30	34	and	and	CCONJ
amwa-142	30	35	they	they	PRON
amwa-142	30	36	apply	apply	VERB
amwa-142	30	37	this	this	DET
amwa-142	30	38	knowledge	knowledge	NOUN
amwa-142	30	39	in	in	ADP
amwa-142	30	40	their	their	PRON
amwa-142	30	41	clinical	clinical	ADJ
amwa-142	30	42	practice	practice	NOUN
amwa-142	30	43	,	,	PUNCT
amwa-142	30	44	thereby	thereby	ADV
amwa-142	30	45	maintaining	maintain	VERB
amwa-142	30	46	a	a	DET
amwa-142	30	47	certain	certain	ADJ
amwa-142	30	48	medical	medical	ADJ
amwa-142	30	49	tradition	tradition	NOUN
amwa-142	30	50	.	.	PUNCT
amwa-142	31	1	such	such	ADJ
amwa-142	31	2	traditions	tradition	NOUN
amwa-142	31	3	are	be	AUX
amwa-142	31	4	tenacious	tenacious	ADJ
amwa-142	31	5	,	,	PUNCT
amwa-142	31	6	and	and	CCONJ
amwa-142	31	7	it	it	PRON
amwa-142	31	8	may	may	AUX
amwa-142	31	9	take	take	VERB
amwa-142	31	10	a	a	DET
amwa-142	31	11	long	long	ADJ
amwa-142	31	12	time	time	NOUN
amwa-142	31	13	before	before	SCONJ
amwa-142	31	14	new	new	ADJ
amwa-142	31	15	therapeutic	therapeutic	ADJ
amwa-142	31	16	options	option	NOUN
amwa-142	31	17	are	be	AUX
amwa-142	31	18	widely	widely	ADV
amwa-142	31	19	accepted	accept	VERB
amwa-142	31	20	and	and	CCONJ
amwa-142	31	21	offered	offer	VERB
amwa-142	31	22	to	to	ADP
amwa-142	31	23	all	all	DET
amwa-142	31	24	patients	patient	NOUN
amwa-142	31	25	.	.	PUNCT
amwa-142	32	1	conversely	conversely	ADV
amwa-142	32	2	,	,	PUNCT
amwa-142	32	3	health	health	NOUN
amwa-142	32	4	care	care	NOUN
amwa-142	32	5	providers	provider	NOUN
amwa-142	32	6	and	and	CCONJ
amwa-142	32	7	hospitals	hospital	NOUN
amwa-142	32	8	may	may	AUX
amwa-142	32	9	continue	continue	VERB
amwa-142	32	10	to	to	PART
amwa-142	32	11	offer	offer	VERB
amwa-142	32	12	treatments	treatment	NOUN
amwa-142	32	13	to	to	ADP
amwa-142	32	14	their	their	PRON
amwa-142	32	15	patients	patient	NOUN
amwa-142	32	16	that	that	PRON
amwa-142	32	17	have	have	AUX
amwa-142	32	18	long	long	ADV
amwa-142	32	19	been	be	AUX
amwa-142	32	20	shown	show	VERB
amwa-142	32	21	to	to	PART
amwa-142	32	22	be	be	AUX
amwa-142	32	23	less	less	ADV
amwa-142	32	24	effective	effective	ADJ
amwa-142	32	25	because	because	SCONJ
amwa-142	32	26	this	this	PRON
amwa-142	32	27	is	be	AUX
amwa-142	32	28	their	their	PRON
amwa-142	32	29	established	establish	VERB
amwa-142	32	30	practice	practice	NOUN
amwa-142	32	31	,	,	PUNCT
amwa-142	32	32	offers	offer	VERB
amwa-142	32	33	financial	financial	ADJ
amwa-142	32	34	advantages	advantage	NOUN
amwa-142	32	35	,	,	PUNCT
amwa-142	32	36	or	or	CCONJ
amwa-142	32	37	is	be	AUX
amwa-142	32	38	expected	expect	VERB
amwa-142	32	39	by	by	ADP
amwa-142	32	40	patients	patient	NOUN
amwa-142	32	41	.	.	PUNCT
amwa-142	33	1	medical	medical	ADJ
amwa-142	33	2	practitioners	practitioner	NOUN
amwa-142	33	3	follow	follow	VERB
amwa-142	33	4	the	the	DET
amwa-142	33	5	insights	insight	NOUN
amwa-142	33	6	they	they	PRON
amwa-142	33	7	gain	gain	VERB
amwa-142	33	8	in	in	ADP
amwa-142	33	9	their	their	PRON
amwa-142	33	10	medical	medical	ADJ
amwa-142	33	11	practice	practice	NOUN
amwa-142	33	12	.	.	PUNCT
amwa-142	34	1	if	if	SCONJ
amwa-142	34	2	they	they	PRON
amwa-142	34	3	have	have	VERB
amwa-142	34	4	the	the	DET
amwa-142	34	5	impression	impression	NOUN
amwa-142	34	6	that	that	SCONJ
amwa-142	34	7	a	a	DET
amwa-142	34	8	particular	particular	ADJ
amwa-142	34	9	medicine	medicine	NOUN
amwa-142	34	10	works	work	VERB
amwa-142	34	11	for	for	ADP
amwa-142	34	12	their	their	PRON
amwa-142	34	13	patients	patient	NOUN
amwa-142	34	14	,	,	PUNCT
amwa-142	34	15	they	they	PRON
amwa-142	34	16	will	will	AUX
amwa-142	34	17	continue	continue	VERB
amwa-142	34	18	to	to	PART
amwa-142	34	19	prescribe	prescribe	VERB
amwa-142	34	20	it	it	PRON
amwa-142	34	21	.	.	PUNCT
amwa-142	35	1	they	they	PRON
amwa-142	35	2	will	will	AUX
amwa-142	35	3	stick	stick	VERB
amwa-142	35	4	to	to	ADP
amwa-142	35	5	what	what	PRON
amwa-142	35	6	they	they	PRON
amwa-142	35	7	believe	believe	VERB
amwa-142	35	8	is	be	AUX
amwa-142	35	9	helpful	helpful	ADJ
amwa-142	35	10	and	and	CCONJ
amwa-142	35	11	may	may	AUX
amwa-142	35	12	not	not	PART
amwa-142	35	13	use	use	VERB
amwa-142	35	14	a	a	DET
amwa-142	35	15	new	new	ADJ
amwa-142	35	16	drug	drug	NOUN
amwa-142	35	17	with	with	ADP
amwa-142	35	18	which	which	PRON
amwa-142	35	19	they	they	PRON
amwa-142	35	20	have	have	VERB
amwa-142	35	21	little	little	ADJ
amwa-142	35	22	experience	experience	NOUN
amwa-142	35	23	.	.	PUNCT
amwa-142	36	1	this	this	PRON
amwa-142	36	2	is	be	AUX
amwa-142	36	3	particularly	particularly	ADV
amwa-142	36	4	likely	likely	ADJ
amwa-142	36	5	when	when	SCONJ
amwa-142	36	6	a	a	DET
amwa-142	36	7	new	new	ADJ
amwa-142	36	8	drug	drug	NOUN
amwa-142	36	9	has	have	AUX
amwa-142	36	10	only	only	ADV
amwa-142	36	11	been	be	AUX
amwa-142	36	12	tested	test	VERB
amwa-142	36	13	against	against	ADP
amwa-142	36	14	placebo	placebo	NOUN
amwa-142	36	15	and	and	CCONJ
amwa-142	36	16	not	not	PART
amwa-142	36	17	against	against	ADP
amwa-142	36	18	established	establish	VERB
amwa-142	36	19	treatments	treatment	NOUN
amwa-142	36	20	.	.	PUNCT
amwa-142	37	1	a	a	DET
amwa-142	37	2	new	new	ADJ
amwa-142	37	3	drug	drug	NOUN
amwa-142	37	4	may	may	AUX
amwa-142	37	5	not	not	PART
amwa-142	37	6	be	be	AUX
amwa-142	37	7	given	give	VERB
amwa-142	37	8	to	to	ADP
amwa-142	37	9	a	a	DET
amwa-142	37	10	patient	patient	NOUN
amwa-142	37	11	because	because	SCONJ
amwa-142	37	12	the	the	DET
amwa-142	37	13	physician	physician	NOUN
amwa-142	37	14	has	have	AUX
amwa-142	37	15	not	not	PART
amwa-142	37	16	heard	hear	VERB
amwa-142	37	17	about	about	ADP
amwa-142	37	18	it	it	PRON
amwa-142	37	19	or	or	CCONJ
amwa-142	37	20	does	do	AUX
amwa-142	37	21	not	not	PART
amwa-142	37	22	believe	believe	VERB
amwa-142	37	23	it	it	PRON
amwa-142	37	24	is	be	AUX
amwa-142	37	25	superior	superior	ADJ
amwa-142	37	26	to	to	ADP
amwa-142	37	27	the	the	DET
amwa-142	37	28	drugs	drug	NOUN
amwa-142	37	29	that	that	PRON
amwa-142	37	30	she	she	PRON
amwa-142	37	31	usually	usually	ADV
amwa-142	37	32	prescribes	prescribe	VERB
amwa-142	37	33	.	.	PUNCT
amwa-142	38	1	issue	issue	NOUN
amwa-142	38	2	3	3	NUM
amwa-142	38	3	:	:	PUNCT
amwa-142	38	4	treatment	treatment	NOUN
amwa-142	38	5	adherence	adherence	NOUN
amwa-142	38	6	in	in	ADP
amwa-142	38	7	clinical	clinical	ADJ
amwa-142	38	8	trials	trial	NOUN
amwa-142	38	9	,	,	PUNCT
amwa-142	38	10	participants	participant	NOUN
amwa-142	38	11	are	be	AUX
amwa-142	38	12	closely	closely	ADV
amwa-142	38	13	monitored	monitor	VERB
amwa-142	38	14	with	with	ADP
amwa-142	38	15	regard	regard	NOUN
amwa-142	38	16	to	to	ADP
amwa-142	38	17	how	how	SCONJ
amwa-142	38	18	and	and	CCONJ
amwa-142	38	19	when	when	SCONJ
amwa-142	38	20	and	and	CCONJ
amwa-142	38	21	at	at	ADP
amwa-142	38	22	which	which	PRON
amwa-142	38	23	dose	dose	NOUN
amwa-142	38	24	they	they	PRON
amwa-142	38	25	take	take	VERB
amwa-142	38	26	their	their	PRON
amwa-142	38	27	medication	medication	NOUN
amwa-142	38	28	.	.	PUNCT
amwa-142	39	1	for	for	ADP
amwa-142	39	2	example	example	NOUN
amwa-142	39	3	,	,	PUNCT
amwa-142	39	4	study	study	NOUN
amwa-142	39	5	participants	participant	NOUN
amwa-142	39	6	are	be	AUX
amwa-142	39	7	reminded	remind	VERB
amwa-142	39	8	to	to	PART
amwa-142	39	9	take	take	VERB
amwa-142	39	10	their	their	PRON
amwa-142	39	11	dose	dose	NOUN
amwa-142	39	12	at	at	ADP
amwa-142	39	13	the	the	DET
amwa-142	39	14	same	same	ADJ
amwa-142	39	15	time	time	NOUN
amwa-142	39	16	every	every	DET
amwa-142	39	17	day	day	NOUN
amwa-142	39	18	,	,	PUNCT
amwa-142	39	19	with	with	ADP
amwa-142	39	20	or	or	CCONJ
amwa-142	39	21	without	without	ADP
amwa-142	39	22	food	food	NOUN
amwa-142	39	23	,	,	PUNCT
amwa-142	39	24	to	to	PART
amwa-142	39	25	achieve	achieve	VERB
amwa-142	39	26	the	the	DET
amwa-142	39	27	optimal	optimal	ADJ
amwa-142	39	28	effect	effect	NOUN
amwa-142	39	29	.	.	PUNCT
amwa-142	40	1	in	in	ADP
amwa-142	40	2	normal	normal	ADJ
amwa-142	40	3	life	life	NOUN
amwa-142	40	4	,	,	PUNCT
amwa-142	40	5	things	thing	NOUN
amwa-142	40	6	tend	tend	VERB
amwa-142	40	7	to	to	PART
amwa-142	40	8	be	be	AUX
amwa-142	40	9	different	different	ADJ
amwa-142	40	10	,	,	PUNCT
amwa-142	40	11	and	and	CCONJ
amwa-142	40	12	patients	patient	NOUN
amwa-142	40	13	might	might	AUX
amwa-142	40	14	occasionally	occasionally	ADV
amwa-142	40	15	forget	forget	VERB
amwa-142	40	16	to	to	PART
amwa-142	40	17	take	take	VERB
amwa-142	40	18	their	their	PRON
amwa-142	40	19	medication	medication	NOUN
amwa-142	40	20	.	.	PUNCT
amwa-142	41	1	on	on	ADP
amwa-142	41	2	days	day	NOUN
amwa-142	41	3	when	when	SCONJ
amwa-142	41	4	their	their	PRON
amwa-142	41	5	disease	disease	NOUN
amwa-142	41	6	is	be	AUX
amwa-142	41	7	particularly	particularly	ADV
amwa-142	41	8	discomforting	discomforte	VERB
amwa-142	41	9	,	,	PUNCT
amwa-142	41	10	they	they	PRON
amwa-142	41	11	may	may	AUX
amwa-142	41	12	be	be	AUX
amwa-142	41	13	inclined	incline	VERB
amwa-142	41	14	to	to	PART
amwa-142	41	15	increase	increase	VERB
amwa-142	41	16	the	the	DET
amwa-142	41	17	dose	dose	NOUN
amwa-142	41	18	of	of	ADP
amwa-142	41	19	their	their	PRON
amwa-142	41	20	medicine	medicine	NOUN
amwa-142	41	21	.	.	PUNCT
amwa-142	42	1	if	if	SCONJ
amwa-142	42	2	their	their	PRON
amwa-142	42	3	lives	life	NOUN
amwa-142	42	4	are	be	AUX
amwa-142	42	5	busy	busy	ADJ
amwa-142	42	6	,	,	PUNCT
amwa-142	42	7	patients	patient	NOUN
amwa-142	42	8	may	may	AUX
amwa-142	42	9	forget	forget	VERB
amwa-142	42	10	to	to	PART
amwa-142	42	11	renew	renew	VERB
amwa-142	42	12	their	their	PRON
amwa-142	42	13	prescription	prescription	NOUN
amwa-142	42	14	in	in	ADP
amwa-142	42	15	time	time	NOUN
amwa-142	42	16	and	and	CCONJ
amwa-142	42	17	may	may	AUX
amwa-142	42	18	therefore	therefore	ADV
amwa-142	42	19	not	not	PART
amwa-142	42	20	take	take	VERB
amwa-142	42	21	any	any	DET
amwa-142	42	22	medication	medication	NOUN
amwa-142	42	23	for	for	ADP
amwa-142	42	24	a	a	DET
amwa-142	42	25	while	while	NOUN
amwa-142	42	26	.	.	PUNCT
amwa-142	43	1	thus	thus	ADV
amwa-142	43	2	,	,	PUNCT
amwa-142	43	3	although	although	SCONJ
amwa-142	43	4	the	the	DET
amwa-142	43	5	drug	drug	NOUN
amwa-142	43	6	is	be	AUX
amwa-142	43	7	available	available	ADJ
amwa-142	43	8	to	to	ADP
amwa-142	43	9	the	the	DET
amwa-142	43	10	patients	patient	NOUN
amwa-142	43	11	,	,	PUNCT
amwa-142	43	12	its	its	PRON
amwa-142	43	13	effects	effect	NOUN
amwa-142	43	14	may	may	AUX
amwa-142	43	15	be	be	AUX
amwa-142	43	16	smaller	small	ADJ
amwa-142	43	17	than	than	ADP
amwa-142	43	18	those	those	PRON
amwa-142	43	19	observed	observe	VERB
amwa-142	43	20	in	in	ADP
amwa-142	43	21	the	the	DET
amwa-142	43	22	clinical	clinical	ADJ
amwa-142	43	23	studies	study	NOUN
amwa-142	43	24	because	because	SCONJ
amwa-142	43	25	of	of	ADP
amwa-142	43	26	limited	limited	ADJ
amwa-142	43	27	adherence	adherence	NOUN
amwa-142	43	28	to	to	ADP
amwa-142	43	29	medication	medication	NOUN
amwa-142	43	30	plans	plan	NOUN
amwa-142	43	31	.	.	PUNCT
amwa-142	44	1	furthermore	furthermore	ADV
amwa-142	44	2	,	,	PUNCT
amwa-142	44	3	patients	patient	NOUN
amwa-142	44	4	might	might	AUX
amwa-142	44	5	be	be	AUX
amwa-142	44	6	taking	take	VERB
amwa-142	44	7	additional	additional	ADJ
amwa-142	44	8	drugs	drug	NOUN
amwa-142	44	9	to	to	PART
amwa-142	44	10	treat	treat	VERB
amwa-142	44	11	other	other	ADJ
amwa-142	44	12	conditions	condition	NOUN
amwa-142	44	13	,	,	PUNCT
amwa-142	44	14	and	and	CCONJ
amwa-142	44	15	these	these	DET
amwa-142	44	16	drugs	drug	NOUN
amwa-142	44	17	may	may	AUX
amwa-142	44	18	influence	influence	VERB
amwa-142	44	19	the	the	DET
amwa-142	44	20	effects	effect	NOUN
amwa-142	44	21	of	of	ADP
amwa-142	44	22	the	the	DET
amwa-142	44	23	new	new	ADJ
amwa-142	44	24	treatment	treatment	NOUN
amwa-142	44	25	.	.	PUNCT
amwa-142	45	1	real	real	ADJ
amwa-142	45	2	-	-	PUNCT
amwa-142	45	3	world	world	NOUN
amwa-142	45	4	data	datum	NOUN
amwa-142	45	5	and	and	CCONJ
amwa-142	45	6	real	real	ADJ
amwa-142	45	7	-	-	PUNCT
amwa-142	45	8	world	world	NOUN
amwa-142	45	9	evidence	evidence	NOUN
amwa-142	45	10	to	to	PART
amwa-142	45	11	determine	determine	VERB
amwa-142	45	12	effectiveness	effectiveness	NOUN
amwa-142	45	13	many	many	ADJ
amwa-142	45	14	different	different	ADJ
amwa-142	45	15	factors	factor	NOUN
amwa-142	45	16	affect	affect	VERB
amwa-142	45	17	the	the	DET
amwa-142	45	18	use	use	NOUN
amwa-142	45	19	of	of	ADP
amwa-142	45	20	a	a	DET
amwa-142	45	21	drug	drug	NOUN
amwa-142	45	22	in	in	ADP
amwa-142	45	23	everyday	everyday	ADJ
amwa-142	45	24	medical	medical	ADJ
amwa-142	45	25	practice	practice	NOUN
amwa-142	45	26	.	.	PUNCT
amwa-142	46	1	it	it	PRON
amwa-142	46	2	is	be	AUX
amwa-142	46	3	therefore	therefore	ADV
amwa-142	46	4	very	very	ADV
amwa-142	46	5	difficult	difficult	ADJ
amwa-142	46	6	to	to	PART
amwa-142	46	7	determine	determine	VERB
amwa-142	46	8	how	how	SCONJ
amwa-142	46	9	effective	effective	ADJ
amwa-142	46	10	a	a	DET
amwa-142	46	11	drug	drug	NOUN
amwa-142	46	12	is	be	AUX
amwa-142	46	13	“	"	PUNCT
amwa-142	46	14	out	out	ADV
amwa-142	46	15	there	there	ADV
amwa-142	46	16	.	.	PUNCT
amwa-142	46	17	”	"	PUNCT
amwa-142	47	1	post	post	ADJ
amwa-142	47	2	-	-	ADJ
amwa-142	47	3	marketing	marketing	ADJ
amwa-142	47	4	(	(	PUNCT
amwa-142	47	5	phase	phase	NOUN
amwa-142	47	6	4	4	NUM
amwa-142	47	7	)	)	PUNCT
amwa-142	47	8	studies	study	NOUN
amwa-142	47	9	usually	usually	ADV
amwa-142	47	10	focus	focus	VERB
amwa-142	47	11	on	on	ADP
amwa-142	47	12	safety	safety	NOUN
amwa-142	47	13	rather	rather	ADV
amwa-142	47	14	than	than	ADP
amwa-142	47	15	effectiveness	effectiveness	NOUN
amwa-142	47	16	.	.	PUNCT
amwa-142	48	1	however	however	ADV
amwa-142	48	2	,	,	PUNCT
amwa-142	48	3	for	for	ADP
amwa-142	48	4	many	many	ADJ
amwa-142	48	5	stakeholders	stakeholder	NOUN
amwa-142	48	6	in	in	ADP
amwa-142	48	7	the	the	DET
amwa-142	48	8	health	health	NOUN
amwa-142	48	9	care	care	NOUN
amwa-142	48	10	system	system	NOUN
amwa-142	48	11	,	,	PUNCT
amwa-142	48	12	it	it	PRON
amwa-142	48	13	is	be	AUX
amwa-142	48	14	important	important	ADJ
amwa-142	48	15	to	to	PART
amwa-142	48	16	know	know	VERB
amwa-142	48	17	how	how	SCONJ
amwa-142	48	18	well	well	ADV
amwa-142	48	19	a	a	DET
amwa-142	48	20	drug	drug	NOUN
amwa-142	48	21	works	work	VERB
amwa-142	48	22	in	in	ADP
amwa-142	48	23	the	the	DET
amwa-142	48	24	real	real	ADJ
amwa-142	48	25	world	world	NOUN
amwa-142	48	26	:	:	PUNCT
amwa-142	48	27	•	•	NUM
amwa-142	48	28	patients	patient	NOUN
amwa-142	48	29	taking	take	VERB
amwa-142	48	30	the	the	DET
amwa-142	48	31	medicine	medicine	NOUN
amwa-142	48	32	want	want	VERB
amwa-142	48	33	to	to	PART
amwa-142	48	34	know	know	VERB
amwa-142	48	35	whether	whether	SCONJ
amwa-142	48	36	it	it	PRON
amwa-142	48	37	works	work	VERB
amwa-142	48	38	,	,	PUNCT
amwa-142	48	39	•	•	NUM
amwa-142	48	40	payers	payer	NOUN
amwa-142	48	41	like	like	ADP
amwa-142	48	42	health	health	NOUN
amwa-142	48	43	insurance	insurance	NOUN
amwa-142	48	44	companies	company	NOUN
amwa-142	48	45	need	need	VERB
amwa-142	48	46	to	to	PART
amwa-142	48	47	understand	understand	VERB
amwa-142	48	48	whether	whether	SCONJ
amwa-142	48	49	they	they	PRON
amwa-142	48	50	are	be	AUX
amwa-142	48	51	paying	pay	VERB
amwa-142	48	52	for	for	ADP
amwa-142	48	53	an	an	DET
amwa-142	48	54	effective	effective	ADJ
amwa-142	48	55	treatment	treatment	NOUN
amwa-142	48	56	,	,	PUNCT
amwa-142	48	57	•	•	NUM
amwa-142	48	58	government	government	NOUN
amwa-142	48	59	agencies	agency	NOUN
amwa-142	48	60	want	want	VERB
amwa-142	48	61	to	to	PART
amwa-142	48	62	know	know	VERB
amwa-142	48	63	how	how	SCONJ
amwa-142	48	64	the	the	DET
amwa-142	48	65	new	new	ADJ
amwa-142	48	66	medicine	medicine	NOUN
amwa-142	48	67	affects	affect	VERB
amwa-142	48	68	public	public	ADJ
amwa-142	48	69	health	health	NOUN
amwa-142	48	70	,	,	PUNCT
amwa-142	48	71	•	•	ADJ
amwa-142	48	72	pharmaceutical	pharmaceutical	NOUN
amwa-142	48	73	companies	company	NOUN
amwa-142	48	74	want	want	VERB
amwa-142	48	75	to	to	PART
amwa-142	48	76	understand	understand	VERB
amwa-142	48	77	to	to	ADP
amwa-142	48	78	what	what	DET
amwa-142	48	79	extent	extent	NOUN
amwa-142	48	80	available	available	ADJ
amwa-142	48	81	medicines	medicine	NOUN
amwa-142	48	82	meet	meet	VERB
amwa-142	48	83	patients	patient	NOUN
amwa-142	48	84	’	'	PUNCT
amwa-142	48	85	needs	need	NOUN
amwa-142	48	86	and	and	CCONJ
amwa-142	48	87	whether	whether	SCONJ
amwa-142	48	88	there	there	PRON
amwa-142	48	89	is	be	VERB
amwa-142	48	90	space	space	NOUN
amwa-142	48	91	for	for	ADP
amwa-142	48	92	additional	additional	ADJ
amwa-142	48	93	medicines	medicine	NOUN
amwa-142	48	94	.	.	PUNCT
amwa-142	49	1	recently	recently	ADV
amwa-142	49	2	,	,	PUNCT
amwa-142	49	3	there	there	PRON
amwa-142	49	4	has	have	AUX
amwa-142	49	5	been	be	AUX
amwa-142	49	6	much	much	ADJ
amwa-142	49	7	discussion	discussion	NOUN
amwa-142	49	8	about	about	ADP
amwa-142	49	9	the	the	DET
amwa-142	49	10	usefulness	usefulness	NOUN
amwa-142	49	11	of	of	ADP
amwa-142	49	12	“	"	PUNCT
amwa-142	49	13	real	real	ADJ
amwa-142	49	14	-	-	PUNCT
amwa-142	49	15	world	world	NOUN
amwa-142	49	16	data	datum	NOUN
amwa-142	49	17	”	"	PUNCT
amwa-142	49	18	(	(	PUNCT
amwa-142	49	19	rwd	rwd	NOUN
amwa-142	49	20	)	)	PUNCT
amwa-142	49	21	and	and	CCONJ
amwa-142	49	22	”	"	PUNCT
amwa-142	49	23	real	real	ADJ
amwa-142	49	24	-	-	PUNCT
amwa-142	49	25	world	world	NOUN
amwa-142	49	26	evidence	evidence	NOUN
amwa-142	49	27	”	"	PUNCT
amwa-142	49	28	(	(	PUNCT
amwa-142	49	29	rwe	rwe	PROPN
amwa-142	49	30	)	)	PUNCT
amwa-142	49	31	to	to	PART
amwa-142	49	32	evaluate	evaluate	VERB
amwa-142	49	33	effectiveness	effectiveness	NOUN
amwa-142	49	34	of	of	ADP
amwa-142	49	35	treatments	treatment	NOUN
amwa-142	49	36	and	and	CCONJ
amwa-142	49	37	support	support	VERB
amwa-142	49	38	health	health	NOUN
amwa-142	49	39	care	care	NOUN
amwa-142	49	40	decisions	decision	NOUN
amwa-142	49	41	.	.	PUNCT
amwa-142	50	1	rwd	rwd	NOUN
amwa-142	50	2	and	and	CCONJ
amwa-142	50	3	rwe	rwe	PROPN
amwa-142	50	4	are	be	AUX
amwa-142	50	5	generally	generally	ADV
amwa-142	50	6	understood	understand	VERB
amwa-142	50	7	to	to	PART
amwa-142	50	8	refer	refer	VERB
amwa-142	50	9	to	to	ADP
amwa-142	50	10	data	datum	NOUN
amwa-142	50	11	and	and	CCONJ
amwa-142	50	12	evidence	evidence	NOUN
amwa-142	50	13	from	from	ADP
amwa-142	50	14	sources	source	NOUN
amwa-142	50	15	other	other	ADJ
amwa-142	50	16	than	than	ADP
amwa-142	50	17	traditional	traditional	ADJ
amwa-142	50	18	clinical	clinical	ADJ
amwa-142	50	19	trials	trial	NOUN
amwa-142	50	20	,	,	PUNCT
amwa-142	50	21	but	but	CCONJ
amwa-142	50	22	it	it	PRON
amwa-142	50	23	has	have	AUX
amwa-142	50	24	not	not	PART
amwa-142	50	25	always	always	ADV
amwa-142	50	26	been	be	AUX
amwa-142	50	27	clear	clear	ADJ
amwa-142	50	28	exactly	exactly	ADV
amwa-142	50	29	what	what	PRON
amwa-142	50	30	these	these	DET
amwa-142	50	31	categories	category	NOUN
amwa-142	50	32	include	include	VERB
amwa-142	50	33	.	.	PUNCT
amwa-142	51	1	over	over	ADP
amwa-142	51	2	a	a	DET
amwa-142	51	3	number	number	NOUN
amwa-142	51	4	of	of	ADP
amwa-142	51	5	years	year	NOUN
amwa-142	51	6	,	,	PUNCT
amwa-142	51	7	regulators	regulator	NOUN
amwa-142	51	8	were	be	AUX
amwa-142	51	9	pressed	press	VERB
amwa-142	51	10	to	to	PART
amwa-142	51	11	delineate	delineate	VERB
amwa-142	51	12	ways	way	NOUN
amwa-142	51	13	to	to	PART
amwa-142	51	14	incorporate	incorporate	VERB
amwa-142	51	15	nonclassical	nonclassical	ADJ
amwa-142	51	16	data	datum	NOUN
amwa-142	51	17	in	in	ADP
amwa-142	51	18	their	their	PRON
amwa-142	51	19	evaluations	evaluation	NOUN
amwa-142	51	20	.	.	PUNCT
amwa-142	52	1	in	in	ADP
amwa-142	52	2	2018	2018	NUM
amwa-142	52	3	,	,	PUNCT
amwa-142	52	4	the	the	DET
amwa-142	52	5	us	us	PROPN
amwa-142	52	6	food	food	NOUN
amwa-142	52	7	and	and	CCONJ
amwa-142	52	8	drug	drug	PROPN
amwa-142	52	9	administration	administration	PROPN
amwa-142	52	10	(	(	PUNCT
amwa-142	52	11	fda	fda	PROPN
amwa-142	52	12	)	)	PUNCT
amwa-142	52	13	released	release	VERB
amwa-142	52	14	the	the	DET
amwa-142	52	15	framework	framework	NOUN
amwa-142	52	16	for	for	ADP
amwa-142	52	17	the	the	DET
amwa-142	52	18	agency	agency	NOUN
amwa-142	52	19	’s	’s	PART
amwa-142	52	20	real	real	ADJ
amwa-142	52	21	-	-	PUNCT
amwa-142	52	22	world	world	NOUN
amwa-142	52	23	evidence	evidence	NOUN
amwa-142	52	24	program	program	NOUN
amwa-142	52	25	.	.	PUNCT
amwa-142	53	1	there	there	ADV
amwa-142	53	2	,	,	PUNCT
amwa-142	53	3	they	they	PRON
amwa-142	53	4	give	give	VERB
amwa-142	53	5	the	the	DET
amwa-142	53	6	following	follow	VERB
amwa-142	53	7	definitions	definition	NOUN
amwa-142	53	8	:	:	PUNCT
amwa-142	53	9	•	•	NUM
amwa-142	53	10	rwd	rwd	NOUN
amwa-142	53	11	is	be	AUX
amwa-142	53	12	“	"	PUNCT
amwa-142	53	13	data	datum	NOUN
amwa-142	53	14	relating	relate	VERB
amwa-142	53	15	to	to	ADP
amwa-142	53	16	patient	patient	ADJ
amwa-142	53	17	health	health	NOUN
amwa-142	53	18	status	status	NOUN
amwa-142	53	19	and/or	and/or	CCONJ
amwa-142	53	20	the	the	DET
amwa-142	53	21	delivery	delivery	NOUN
amwa-142	53	22	of	of	ADP
amwa-142	53	23	health	health	NOUN
amwa-142	53	24	care	care	NOUN
amwa-142	53	25	routinely	routinely	ADV
amwa-142	53	26	collected	collect	VERB
amwa-142	53	27	from	from	ADP
amwa-142	53	28	a	a	DET
amwa-142	53	29	variety	variety	NOUN
amwa-142	53	30	of	of	ADP
amwa-142	53	31	sources	source	NOUN
amwa-142	53	32	.	.	PUNCT
amwa-142	53	33	”	"	PUNCT
amwa-142	54	1	•	•	NUM
amwa-142	54	2	rwe	rwe	PROPN
amwa-142	54	3	is	be	AUX
amwa-142	54	4	“	"	PUNCT
amwa-142	54	5	the	the	DET
amwa-142	54	6	clinical	clinical	ADJ
amwa-142	54	7	evidence	evidence	NOUN
amwa-142	54	8	about	about	ADP
amwa-142	54	9	the	the	DET
amwa-142	54	10	usage	usage	NOUN
amwa-142	54	11	and	and	CCONJ
amwa-142	54	12	potential	potential	ADJ
amwa-142	54	13	benefits	benefit	NOUN
amwa-142	54	14	or	or	CCONJ
amwa-142	54	15	risks	risk	NOUN
amwa-142	54	16	of	of	ADP
amwa-142	54	17	a	a	DET
amwa-142	54	18	medical	medical	ADJ
amwa-142	54	19	product	product	NOUN
amwa-142	54	20	derived	derive	VERB
amwa-142	54	21	from	from	ADP
amwa-142	54	22	analysis	analysis	NOUN
amwa-142	54	23	of	of	ADP
amwa-142	54	24	rwd	rwd	NOUN
amwa-142	54	25	.	.	PUNCT
amwa-142	54	26	”	"	PUNCT
amwa-142	55	1	real	real	ADJ
amwa-142	55	2	-	-	PUNCT
amwa-142	55	3	world	world	NOUN
amwa-142	55	4	data	datum	NOUN
amwa-142	55	5	:	:	PUNCT
amwa-142	55	6	abundant	abundant	ADJ
amwa-142	55	7	,	,	PUNCT
amwa-142	55	8	promising	promising	ADJ
amwa-142	55	9	,	,	PUNCT
amwa-142	55	10	but	but	CCONJ
amwa-142	55	11	messy	messy	ADJ
amwa-142	55	12	sources	source	NOUN
amwa-142	55	13	of	of	ADP
amwa-142	55	14	rwd	rwd	NOUN
amwa-142	55	15	include	include	VERB
amwa-142	55	16	registries	registry	NOUN
amwa-142	55	17	,	,	PUNCT
amwa-142	55	18	electronic	electronic	ADJ
amwa-142	55	19	health	health	NOUN
amwa-142	55	20	records	record	NOUN
amwa-142	55	21	,	,	PUNCT
amwa-142	55	22	medical	medical	ADJ
amwa-142	55	23	claims	claim	NOUN
amwa-142	55	24	databases	database	NOUN
amwa-142	55	25	,	,	PUNCT
amwa-142	55	26	mobile	mobile	ADJ
amwa-142	55	27	devices	device	NOUN
amwa-142	55	28	,	,	PUNCT
amwa-142	55	29	and	and	CCONJ
amwa-142	55	30	so	so	ADV
amwa-142	55	31	on	on	ADV
amwa-142	55	32	.	.	PUNCT
amwa-142	56	1	the	the	DET
amwa-142	56	2	recent	recent	ADJ
amwa-142	56	3	excitement	excitement	NOUN
amwa-142	56	4	about	about	ADP
amwa-142	56	5	rwd	rwd	NOUN
amwa-142	56	6	and	and	CCONJ
amwa-142	56	7	rwe	rwe	PROPN
amwa-142	56	8	has	have	AUX
amwa-142	56	9	focused	focus	VERB
amwa-142	56	10	on	on	ADP
amwa-142	56	11	the	the	DET
amwa-142	56	12	availability	availability	NOUN
amwa-142	56	13	of	of	ADP
amwa-142	56	14	apparently	apparently	ADV
amwa-142	56	15	rich	rich	ADJ
amwa-142	56	16	sources	source	NOUN
amwa-142	56	17	of	of	ADP
amwa-142	56	18	data	datum	NOUN
amwa-142	56	19	,	,	PUNCT
amwa-142	56	20	particularly	particularly	ADV
amwa-142	56	21	those	those	PRON
amwa-142	56	22	resulting	result	VERB
amwa-142	56	23	from	from	ADP
amwa-142	56	24	digitization	digitization	NOUN
amwa-142	56	25	.	.	PUNCT
amwa-142	57	1	sources	source	NOUN
amwa-142	57	2	such	such	ADJ
amwa-142	57	3	as	as	ADP
amwa-142	57	4	electronic	electronic	ADJ
amwa-142	57	5	health	health	NOUN
amwa-142	57	6	records	record	NOUN
amwa-142	57	7	from	from	ADP
amwa-142	57	8	entire	entire	ADJ
amwa-142	57	9	health	health	NOUN
amwa-142	57	10	systems	system	NOUN
amwa-142	57	11	or	or	CCONJ
amwa-142	57	12	wearable	wearable	ADJ
amwa-142	57	13	devices	device	NOUN
amwa-142	57	14	that	that	PRON
amwa-142	57	15	generate	generate	VERB
amwa-142	57	16	data	datum	NOUN
amwa-142	57	17	on	on	ADP
amwa-142	57	18	a	a	DET
amwa-142	57	19	plethora	plethora	NOUN
amwa-142	57	20	of	of	ADP
amwa-142	57	21	variables	variable	NOUN
amwa-142	57	22	at	at	ADP
amwa-142	57	23	frequent	frequent	ADJ
amwa-142	57	24	intervals	interval	NOUN
amwa-142	57	25	promise	promise	VERB
amwa-142	57	26	an	an	DET
amwa-142	57	27	abundance	abundance	NOUN
amwa-142	57	28	of	of	ADP
amwa-142	57	29	easily	easily	ADV
amwa-142	57	30	collected	collect	VERB
amwa-142	57	31	data	datum	NOUN
amwa-142	57	32	.	.	PUNCT
amwa-142	58	1	there	there	PRON
amwa-142	58	2	is	be	VERB
amwa-142	58	3	a	a	DET
amwa-142	58	4	growing	grow	VERB
amwa-142	58	5	tendency	tendency	NOUN
amwa-142	58	6	to	to	PART
amwa-142	58	7	believe	believe	VERB
amwa-142	58	8	that	that	SCONJ
amwa-142	58	9	data	datum	NOUN
amwa-142	58	10	collected	collect	VERB
amwa-142	58	11	in	in	ADP
amwa-142	58	12	the	the	DET
amwa-142	58	13	course	course	NOUN
amwa-142	58	14	of	of	ADP
amwa-142	58	15	routine	routine	ADJ
amwa-142	58	16	health	health	NOUN
amwa-142	58	17	care	care	NOUN
amwa-142	58	18	,	,	PUNCT
amwa-142	58	19	whether	whether	SCONJ
amwa-142	58	20	via	via	ADP
amwa-142	58	21	the	the	DET
amwa-142	58	22	records	record	NOUN
amwa-142	58	23	kept	keep	VERB
amwa-142	58	24	by	by	ADP
amwa-142	58	25	health	health	NOUN
amwa-142	58	26	care	care	NOUN
amwa-142	58	27	providers	provider	NOUN
amwa-142	58	28	or	or	CCONJ
amwa-142	58	29	directly	directly	ADV
amwa-142	58	30	from	from	ADP
amwa-142	58	31	patients	patient	NOUN
amwa-142	58	32	using	use	VERB
amwa-142	58	33	apps	app	NOUN
amwa-142	58	34	,	,	PUNCT
amwa-142	58	35	better	well	ADV
amwa-142	58	36	reflect	reflect	VERB
amwa-142	58	37	how	how	SCONJ
amwa-142	58	38	treatments	treatment	NOUN
amwa-142	58	39	actually	actually	ADV
amwa-142	58	40	perform	perform	VERB
amwa-142	58	41	than	than	ADP
amwa-142	58	42	data	datum	NOUN
amwa-142	58	43	collected	collect	VERB
amwa-142	58	44	in	in	ADP
amwa-142	58	45	the	the	DET
amwa-142	58	46	research	research	NOUN
amwa-142	58	47	settings	setting	NOUN
amwa-142	58	48	of	of	ADP
amwa-142	58	49	clinical	clinical	ADJ
amwa-142	58	50	trials	trial	NOUN
amwa-142	58	51	.	.	PUNCT
amwa-142	59	1	large	large	ADJ
amwa-142	59	2	quantities	quantity	NOUN
amwa-142	59	3	of	of	ADP
amwa-142	59	4	rwd	rwd	NOUN
amwa-142	59	5	can	can	AUX
amwa-142	59	6	easily	easily	ADV
amwa-142	59	7	be	be	AUX
amwa-142	59	8	collected	collect	VERB
amwa-142	59	9	from	from	ADP
amwa-142	59	10	thousands	thousand	NOUN
amwa-142	59	11	,	,	PUNCT
amwa-142	59	12	or	or	CCONJ
amwa-142	59	13	even	even	ADV
amwa-142	59	14	millions	million	NOUN
amwa-142	59	15	,	,	PUNCT
amwa-142	59	16	of	of	ADP
amwa-142	59	17	patients	patient	NOUN
amwa-142	59	18	,	,	PUNCT
amwa-142	59	19	and	and	CCONJ
amwa-142	59	20	such	such	ADJ
amwa-142	59	21	“	"	PUNCT
amwa-142	59	22	big	big	ADJ
amwa-142	59	23	data	datum	NOUN
amwa-142	59	24	”	"	PUNCT
amwa-142	59	25	seem	seem	VERB
amwa-142	59	26	to	to	PART
amwa-142	59	27	promise	promise	VERB
amwa-142	59	28	greater	great	ADJ
amwa-142	59	29	representativeness	representativeness	ADJ
amwa-142	59	30	than	than	ADP
amwa-142	59	31	data	datum	NOUN
amwa-142	59	32	from	from	ADP
amwa-142	59	33	the	the	DET
amwa-142	59	34	comparatively	comparatively	ADV
amwa-142	59	35	small	small	ADJ
amwa-142	59	36	,	,	PUNCT
amwa-142	59	37	selected	select	VERB
amwa-142	59	38	populations	population	NOUN
amwa-142	59	39	of	of	ADP
amwa-142	59	40	patients	patient	NOUN
amwa-142	59	41	included	include	VERB
amwa-142	59	42	in	in	ADP
amwa-142	59	43	clinical	clinical	ADJ
amwa-142	59	44	trials	trial	NOUN
amwa-142	59	45	.	.	PUNCT
amwa-142	60	1	there	there	PRON
amwa-142	60	2	are	be	VERB
amwa-142	60	3	also	also	ADV
amwa-142	60	4	clear	clear	ADJ
amwa-142	60	5	practical	practical	ADJ
amwa-142	60	6	and	and	CCONJ
amwa-142	60	7	economic	economic	ADJ
amwa-142	60	8	grounds	ground	NOUN
amwa-142	60	9	for	for	ADP
amwa-142	60	10	exploring	explore	VERB
amwa-142	60	11	rwd	rwd	NOUN
amwa-142	60	12	:	:	PUNCT
amwa-142	60	13	vast	vast	ADJ
amwa-142	60	14	quantities	quantity	NOUN
amwa-142	60	15	of	of	ADP
amwa-142	60	16	such	such	ADJ
amwa-142	60	17	data	datum	NOUN
amwa-142	60	18	can	can	AUX
amwa-142	60	19	be	be	AUX
amwa-142	60	20	collected	collect	VERB
amwa-142	60	21	and	and	CCONJ
amwa-142	60	22	accessed	access	VERB
amwa-142	60	23	quickly	quickly	ADV
amwa-142	60	24	and	and	CCONJ
amwa-142	60	25	cheaply	cheaply	ADV
amwa-142	60	26	by	by	ADP
amwa-142	60	27	comparison	comparison	NOUN
amwa-142	60	28	with	with	ADP
amwa-142	60	29	the	the	DET
amwa-142	60	30	laborious	laborious	ADJ
amwa-142	60	31	and	and	CCONJ
amwa-142	60	32	costly	costly	ADJ
amwa-142	60	33	collection	collection	NOUN
amwa-142	60	34	of	of	ADP
amwa-142	60	35	data	datum	NOUN
amwa-142	60	36	in	in	ADP
amwa-142	60	37	traditional	traditional	ADJ
amwa-142	60	38	clinical	clinical	ADJ
amwa-142	60	39	trials	trial	NOUN
amwa-142	60	40	.	.	PUNCT
amwa-142	61	1	rwd	rwd	NOUN
amwa-142	61	2	therefore	therefore	ADV
amwa-142	61	3	holds	hold	VERB
amwa-142	61	4	appeal	appeal	NOUN
amwa-142	61	5	for	for	ADP
amwa-142	61	6	companies	company	NOUN
amwa-142	61	7	keen	keen	ADJ
amwa-142	61	8	to	to	PART
amwa-142	61	9	reduce	reduce	VERB
amwa-142	61	10	the	the	DET
amwa-142	61	11	expense	expense	NOUN
amwa-142	61	12	and	and	CCONJ
amwa-142	61	13	time	time	NOUN
amwa-142	61	14	taken	take	VERB
amwa-142	61	15	to	to	PART
amwa-142	61	16	bring	bring	VERB
amwa-142	61	17	treatments	treatment	NOUN
amwa-142	61	18	to	to	ADP
amwa-142	61	19	market	market	NOUN
amwa-142	61	20	.	.	PUNCT
amwa-142	62	1	statistically	statistically	ADV
amwa-142	62	2	speaking	speak	VERB
amwa-142	62	3	36	36	NUM
amwa-142	62	4	amwa	amwa	PROPN
amwa-142	62	5	journal	journal	PROPN
amwa-142	62	6	/	/	SYM
amwa-142	62	7	v36	v36	PROPN
amwa-142	62	8	n1	n1	PROPN
amwa-142	62	9	/	/	SYM
amwa-142	62	10	2021	2021	NUM
amwa-142	62	11	/	/	SYM
amwa-142	62	12	amwa.org	amwa.org	X
amwa-142	62	13	easy	easy	ADJ
amwa-142	62	14	and	and	CCONJ
amwa-142	62	15	cost	cost	NOUN
amwa-142	62	16	-	-	PUNCT
amwa-142	62	17	effective	effective	ADJ
amwa-142	62	18	access	access	NOUN
amwa-142	62	19	to	to	ADP
amwa-142	62	20	large	large	ADJ
amwa-142	62	21	quantities	quantity	NOUN
amwa-142	62	22	of	of	ADP
amwa-142	62	23	medical	medical	ADJ
amwa-142	62	24	data	datum	NOUN
amwa-142	62	25	collected	collect	VERB
amwa-142	62	26	from	from	ADP
amwa-142	62	27	the	the	DET
amwa-142	62	28	full	full	ADJ
amwa-142	62	29	range	range	NOUN
amwa-142	62	30	of	of	ADP
amwa-142	62	31	users	user	NOUN
amwa-142	62	32	of	of	ADP
amwa-142	62	33	a	a	DET
amwa-142	62	34	treatment	treatment	NOUN
amwa-142	62	35	in	in	ADP
amwa-142	62	36	real	real	ADJ
amwa-142	62	37	-	-	PUNCT
amwa-142	62	38	world	world	NOUN
amwa-142	62	39	conditions	condition	NOUN
amwa-142	62	40	may	may	AUX
amwa-142	62	41	sound	sound	VERB
amwa-142	62	42	too	too	ADV
amwa-142	62	43	good	good	ADJ
amwa-142	62	44	to	to	PART
amwa-142	62	45	be	be	AUX
amwa-142	62	46	true	true	ADJ
amwa-142	62	47	.	.	PUNCT
amwa-142	63	1	sure	sure	ADJ
amwa-142	63	2	enough	enough	ADV
amwa-142	63	3	,	,	PUNCT
amwa-142	63	4	there	there	PRON
amwa-142	63	5	are	be	VERB
amwa-142	63	6	several	several	ADJ
amwa-142	63	7	major	major	ADJ
amwa-142	63	8	obstacles	obstacle	NOUN
amwa-142	63	9	to	to	ADP
amwa-142	63	10	using	use	VERB
amwa-142	63	11	rwd	rwd	NOUN
amwa-142	63	12	to	to	PART
amwa-142	63	13	reach	reach	VERB
amwa-142	63	14	reliable	reliable	ADJ
amwa-142	63	15	conclusions	conclusion	NOUN
amwa-142	63	16	regarding	regard	VERB
amwa-142	63	17	the	the	DET
amwa-142	63	18	effectiveness	effectiveness	NOUN
amwa-142	63	19	of	of	ADP
amwa-142	63	20	treatments	treatment	NOUN
amwa-142	63	21	.	.	PUNCT
amwa-142	64	1	obstacle	obstacle	NOUN
amwa-142	64	2	1	1	NUM
amwa-142	64	3	:	:	PUNCT
amwa-142	64	4	data	datum	NOUN
amwa-142	64	5	quality	quality	NOUN
amwa-142	64	6	one	one	NUM
amwa-142	64	7	of	of	ADP
amwa-142	64	8	the	the	DET
amwa-142	64	9	factors	factor	NOUN
amwa-142	64	10	behind	behind	ADP
amwa-142	64	11	the	the	DET
amwa-142	64	12	expense	expense	NOUN
amwa-142	64	13	of	of	ADP
amwa-142	64	14	running	run	VERB
amwa-142	64	15	clinical	clinical	ADJ
amwa-142	64	16	trials	trial	NOUN
amwa-142	64	17	is	be	AUX
amwa-142	64	18	the	the	DET
amwa-142	64	19	quest	quest	NOUN
amwa-142	64	20	for	for	ADP
amwa-142	64	21	good	good	ADJ
amwa-142	64	22	data	datum	NOUN
amwa-142	64	23	quality	quality	NOUN
amwa-142	64	24	and	and	CCONJ
amwa-142	64	25	the	the	DET
amwa-142	64	26	consequent	consequent	ADJ
amwa-142	64	27	rigor	rigor	NOUN
amwa-142	64	28	with	with	ADP
amwa-142	64	29	which	which	PRON
amwa-142	64	30	data	datum	NOUN
amwa-142	64	31	are	be	AUX
amwa-142	64	32	collected	collect	VERB
amwa-142	64	33	.	.	PUNCT
amwa-142	65	1	the	the	DET
amwa-142	65	2	clinical	clinical	ADJ
amwa-142	65	3	trial	trial	NOUN
amwa-142	65	4	protocol	protocol	NOUN
amwa-142	65	5	specifies	specifie	NOUN
amwa-142	65	6	precisely	precisely	ADV
amwa-142	65	7	which	which	DET
amwa-142	65	8	data	datum	NOUN
amwa-142	65	9	are	be	AUX
amwa-142	65	10	to	to	PART
amwa-142	65	11	be	be	AUX
amwa-142	65	12	collected	collect	VERB
amwa-142	65	13	for	for	ADP
amwa-142	65	14	each	each	DET
amwa-142	65	15	patient	patient	NOUN
amwa-142	65	16	,	,	PUNCT
amwa-142	65	17	the	the	DET
amwa-142	65	18	time	time	NOUN
amwa-142	65	19	points	point	NOUN
amwa-142	65	20	at	at	ADP
amwa-142	65	21	which	which	PRON
amwa-142	65	22	they	they	PRON
amwa-142	65	23	are	be	AUX
amwa-142	65	24	to	to	PART
amwa-142	65	25	be	be	AUX
amwa-142	65	26	collected	collect	VERB
amwa-142	65	27	,	,	PUNCT
amwa-142	65	28	and	and	CCONJ
amwa-142	65	29	the	the	DET
amwa-142	65	30	methods	method	NOUN
amwa-142	65	31	,	,	PUNCT
amwa-142	65	32	often	often	ADV
amwa-142	65	33	including	include	VERB
amwa-142	65	34	the	the	DET
amwa-142	65	35	precise	precise	ADJ
amwa-142	65	36	equipment	equipment	NOUN
amwa-142	65	37	,	,	PUNCT
amwa-142	65	38	that	that	PRON
amwa-142	65	39	are	be	AUX
amwa-142	65	40	to	to	PART
amwa-142	65	41	be	be	AUX
amwa-142	65	42	used	use	VERB
amwa-142	65	43	.	.	PUNCT
amwa-142	66	1	a	a	DET
amwa-142	66	2	trial	trial	NOUN
amwa-142	66	3	is	be	AUX
amwa-142	66	4	designed	design	VERB
amwa-142	66	5	to	to	PART
amwa-142	66	6	answer	answer	VERB
amwa-142	66	7	specific	specific	ADJ
amwa-142	66	8	scientific	scientific	ADJ
amwa-142	66	9	questions	question	NOUN
amwa-142	66	10	,	,	PUNCT
amwa-142	66	11	and	and	CCONJ
amwa-142	66	12	the	the	DET
amwa-142	66	13	data	datum	NOUN
amwa-142	66	14	to	to	PART
amwa-142	66	15	be	be	AUX
amwa-142	66	16	collected	collect	VERB
amwa-142	66	17	are	be	AUX
amwa-142	66	18	those	those	PRON
amwa-142	66	19	that	that	PRON
amwa-142	66	20	are	be	AUX
amwa-142	66	21	required	require	VERB
amwa-142	66	22	to	to	PART
amwa-142	66	23	answer	answer	VERB
amwa-142	66	24	these	these	DET
amwa-142	66	25	questions	question	NOUN
amwa-142	66	26	.	.	PUNCT
amwa-142	67	1	data	datum	NOUN
amwa-142	67	2	are	be	AUX
amwa-142	67	3	recorded	record	VERB
amwa-142	67	4	on	on	ADP
amwa-142	67	5	a	a	DET
amwa-142	67	6	case	case	NOUN
amwa-142	67	7	report	report	NOUN
amwa-142	67	8	form	form	NOUN
amwa-142	67	9	designed	design	VERB
amwa-142	67	10	specifically	specifically	ADV
amwa-142	67	11	for	for	ADP
amwa-142	67	12	the	the	DET
amwa-142	67	13	trial	trial	NOUN
amwa-142	67	14	.	.	PUNCT
amwa-142	68	1	strict	strict	ADJ
amwa-142	68	2	procedures	procedure	NOUN
amwa-142	68	3	are	be	AUX
amwa-142	68	4	followed	follow	VERB
amwa-142	68	5	to	to	PART
amwa-142	68	6	ensure	ensure	VERB
amwa-142	68	7	data	datum	NOUN
amwa-142	68	8	are	be	AUX
amwa-142	68	9	collected	collect	VERB
amwa-142	68	10	in	in	ADP
amwa-142	68	11	accordance	accordance	NOUN
amwa-142	68	12	with	with	ADP
amwa-142	68	13	good	good	ADJ
amwa-142	68	14	clinical	clinical	ADJ
amwa-142	68	15	practice	practice	NOUN
amwa-142	68	16	principles	principle	NOUN
amwa-142	68	17	,	,	PUNCT
amwa-142	68	18	and	and	CCONJ
amwa-142	68	19	clinical	clinical	ADJ
amwa-142	68	20	trial	trial	NOUN
amwa-142	68	21	monitors	monitor	NOUN
amwa-142	68	22	verify	verify	VERB
amwa-142	68	23	the	the	DET
amwa-142	68	24	data	datum	NOUN
amwa-142	68	25	for	for	ADP
amwa-142	68	26	completeness	completeness	NOUN
amwa-142	68	27	and	and	CCONJ
amwa-142	68	28	accuracy	accuracy	NOUN
amwa-142	68	29	.	.	PUNCT
amwa-142	69	1	these	these	DET
amwa-142	69	2	methods	method	NOUN
amwa-142	69	3	ensure	ensure	VERB
amwa-142	69	4	that	that	SCONJ
amwa-142	69	5	clinical	clinical	ADJ
amwa-142	69	6	trial	trial	NOUN
amwa-142	69	7	data	datum	NOUN
amwa-142	69	8	are	be	AUX
amwa-142	69	9	highly	highly	ADV
amwa-142	69	10	standardized	standardized	ADJ
amwa-142	69	11	from	from	ADP
amwa-142	69	12	patient	patient	NOUN
amwa-142	69	13	to	to	ADP
amwa-142	69	14	patient	patient	NOUN
amwa-142	69	15	and	and	CCONJ
amwa-142	69	16	from	from	ADP
amwa-142	69	17	center	center	NOUN
amwa-142	69	18	to	to	ADP
amwa-142	69	19	center	center	NOUN
amwa-142	69	20	,	,	PUNCT
amwa-142	69	21	with	with	ADP
amwa-142	69	22	the	the	DET
amwa-142	69	23	same	same	ADJ
amwa-142	69	24	variables	variable	NOUN
amwa-142	69	25	measured	measure	VERB
amwa-142	69	26	and	and	CCONJ
amwa-142	69	27	recorded	record	VERB
amwa-142	69	28	in	in	ADP
amwa-142	69	29	the	the	DET
amwa-142	69	30	same	same	ADJ
amwa-142	69	31	way	way	NOUN
amwa-142	69	32	and	and	CCONJ
amwa-142	69	33	at	at	ADP
amwa-142	69	34	the	the	DET
amwa-142	69	35	same	same	ADJ
amwa-142	69	36	time	time	NOUN
amwa-142	69	37	points	point	NOUN
amwa-142	69	38	.	.	PUNCT
amwa-142	70	1	these	these	DET
amwa-142	70	2	provisions	provision	NOUN
amwa-142	70	3	make	make	VERB
amwa-142	70	4	clinical	clinical	ADJ
amwa-142	70	5	trial	trial	NOUN
amwa-142	70	6	data	datum	NOUN
amwa-142	70	7	reliable	reliable	ADJ
amwa-142	70	8	and	and	CCONJ
amwa-142	70	9	trustworthy	trustworthy	ADJ
amwa-142	70	10	.	.	PUNCT
amwa-142	71	1	data	datum	NOUN
amwa-142	71	2	from	from	ADP
amwa-142	71	3	real	real	ADJ
amwa-142	71	4	-	-	PUNCT
amwa-142	71	5	world	world	NOUN
amwa-142	71	6	sources	source	NOUN
amwa-142	71	7	are	be	AUX
amwa-142	71	8	unlikely	unlikely	ADJ
amwa-142	71	9	to	to	PART
amwa-142	71	10	share	share	VERB
amwa-142	71	11	any	any	PRON
amwa-142	71	12	of	of	ADP
amwa-142	71	13	these	these	DET
amwa-142	71	14	qualities	quality	NOUN
amwa-142	71	15	.	.	PUNCT
amwa-142	72	1	table	table	NOUN
amwa-142	72	2	1	1	NUM
amwa-142	72	3	outlines	outline	VERB
amwa-142	72	4	the	the	DET
amwa-142	72	5	main	main	ADJ
amwa-142	72	6	problems	problem	NOUN
amwa-142	72	7	with	with	ADP
amwa-142	72	8	quality	quality	NOUN
amwa-142	72	9	of	of	ADP
amwa-142	72	10	rwd	rwd	NOUN
amwa-142	72	11	.	.	PUNCT
amwa-142	73	1	these	these	DET
amwa-142	73	2	deficiencies	deficiency	NOUN
amwa-142	73	3	introduce	introduce	VERB
amwa-142	73	4	noise	noise	NOUN
amwa-142	73	5	and	and	CCONJ
amwa-142	73	6	bias	bias	NOUN
amwa-142	73	7	that	that	PRON
amwa-142	73	8	make	make	VERB
amwa-142	73	9	it	it	PRON
amwa-142	73	10	difficult	difficult	ADJ
amwa-142	73	11	to	to	PART
amwa-142	73	12	draw	draw	VERB
amwa-142	73	13	reliable	reliable	ADJ
amwa-142	73	14	conclusions	conclusion	NOUN
amwa-142	73	15	about	about	ADP
amwa-142	73	16	the	the	DET
amwa-142	73	17	effectiveness	effectiveness	NOUN
amwa-142	73	18	of	of	ADP
amwa-142	73	19	a	a	DET
amwa-142	73	20	treatment	treatment	NOUN
amwa-142	73	21	.	.	PUNCT
amwa-142	74	1	obstacle	obstacle	NOUN
amwa-142	74	2	2	2	NUM
amwa-142	74	3	:	:	PUNCT
amwa-142	74	4	lack	lack	NOUN
amwa-142	74	5	of	of	ADP
amwa-142	74	6	randomization	randomization	NOUN
amwa-142	74	7	medical	medical	ADJ
amwa-142	74	8	research	research	NOUN
amwa-142	74	9	generally	generally	ADV
amwa-142	74	10	falls	fall	VERB
amwa-142	74	11	into	into	ADP
amwa-142	74	12	1	1	NUM
amwa-142	74	13	of	of	ADP
amwa-142	74	14	2	2	NUM
amwa-142	74	15	broad	broad	ADJ
amwa-142	74	16	categories	category	NOUN
amwa-142	74	17	:	:	PUNCT
amwa-142	74	18	clinical	clinical	ADJ
amwa-142	74	19	trials	trial	NOUN
amwa-142	74	20	and	and	CCONJ
amwa-142	74	21	observational	observational	ADJ
amwa-142	74	22	studies	study	NOUN
amwa-142	74	23	(	(	PUNCT
amwa-142	74	24	figure	figure	NOUN
amwa-142	74	25	1	1	NUM
amwa-142	74	26	)	)	PUNCT
amwa-142	74	27	.	.	PUNCT
amwa-142	75	1	the	the	DET
amwa-142	75	2	key	key	ADJ
amwa-142	75	3	feature	feature	NOUN
amwa-142	75	4	that	that	PRON
amwa-142	75	5	separates	separate	VERB
amwa-142	75	6	these	these	DET
amwa-142	75	7	approaches	approach	NOUN
amwa-142	75	8	is	be	AUX
amwa-142	75	9	the	the	DET
amwa-142	75	10	presence	presence	NOUN
amwa-142	75	11	or	or	CCONJ
amwa-142	75	12	absence	absence	NOUN
amwa-142	75	13	of	of	ADP
amwa-142	75	14	randomization	randomization	NOUN
amwa-142	75	15	.	.	PUNCT
amwa-142	76	1	a	a	DET
amwa-142	76	2	recent	recent	ADJ
amwa-142	76	3	opinion	opinion	NOUN
amwa-142	76	4	piece	piece	NOUN
amwa-142	76	5	in	in	ADP
amwa-142	76	6	the	the	DET
amwa-142	76	7	new	new	PROPN
amwa-142	76	8	england	england	PROPN
amwa-142	76	9	journal	journal	PROPN
amwa-142	76	10	of	of	ADP
amwa-142	76	11	medicine	medicine	NOUN
amwa-142	76	12	insightfully	insightfully	ADV
amwa-142	76	13	contrasts	contrast	VERB
amwa-142	76	14	the	the	DET
amwa-142	76	15	“	"	PUNCT
amwa-142	76	16	magic	magic	NOUN
amwa-142	76	17	of	of	ADP
amwa-142	76	18	randomization	randomization	NOUN
amwa-142	76	19	”	"	PUNCT
amwa-142	76	20	in	in	ADP
amwa-142	76	21	rcts	rct	NOUN
amwa-142	76	22	with	with	ADP
amwa-142	76	23	the	the	DET
amwa-142	76	24	“	"	PUNCT
amwa-142	76	25	myth	myth	NOUN
amwa-142	76	26	of	of	ADP
amwa-142	76	27	real	real	ADJ
amwa-142	76	28	-	-	PUNCT
amwa-142	76	29	world	world	NOUN
amwa-142	76	30	evidence	evidence	NOUN
amwa-142	76	31	”	"	PUNCT
amwa-142	76	32	from	from	ADP
amwa-142	76	33	observational	observational	ADJ
amwa-142	76	34	studies	study	NOUN
amwa-142	76	35	.	.	PUNCT
amwa-142	77	1	randomization	randomization	NOUN
amwa-142	77	2	ensures	ensure	VERB
amwa-142	77	3	that	that	SCONJ
amwa-142	77	4	there	there	PRON
amwa-142	77	5	are	be	VERB
amwa-142	77	6	no	no	DET
amwa-142	77	7	systematic	systematic	ADJ
amwa-142	77	8	differences	difference	NOUN
amwa-142	77	9	between	between	ADP
amwa-142	77	10	treatment	treatment	NOUN
amwa-142	77	11	groups	group	NOUN
amwa-142	77	12	with	with	ADP
amwa-142	77	13	regard	regard	NOUN
amwa-142	77	14	to	to	ADP
amwa-142	77	15	patients	patient	NOUN
amwa-142	77	16	’	'	PUNCT
amwa-142	77	17	characteristics	characteristic	NOUN
amwa-142	77	18	that	that	PRON
amwa-142	77	19	may	may	AUX
amwa-142	77	20	affect	affect	VERB
amwa-142	77	21	efficacy	efficacy	NOUN
amwa-142	77	22	outcomes	outcome	NOUN
amwa-142	77	23	.	.	PUNCT
amwa-142	78	1	it	it	PRON
amwa-142	78	2	is	be	AUX
amwa-142	78	3	likely	likely	ADV
amwa-142	78	4	impossible	impossible	ADJ
amwa-142	78	5	to	to	PART
amwa-142	78	6	achieve	achieve	VERB
amwa-142	78	7	such	such	DET
amwa-142	78	8	a	a	DET
amwa-142	78	9	balance	balance	NOUN
amwa-142	78	10	in	in	ADP
amwa-142	78	11	an	an	DET
amwa-142	78	12	observational	observational	ADJ
amwa-142	78	13	study	study	NOUN
amwa-142	78	14	because	because	SCONJ
amwa-142	78	15	the	the	DET
amwa-142	78	16	groups	group	NOUN
amwa-142	78	17	that	that	PRON
amwa-142	78	18	are	be	AUX
amwa-142	78	19	compared	compare	VERB
amwa-142	78	20	did	do	AUX
amwa-142	78	21	not	not	PART
amwa-142	78	22	result	result	VERB
amwa-142	78	23	from	from	ADP
amwa-142	78	24	randomization	randomization	NOUN
amwa-142	78	25	.	.	PUNCT
amwa-142	79	1	whenever	whenever	SCONJ
amwa-142	79	2	the	the	DET
amwa-142	79	3	treatment	treatment	NOUN
amwa-142	79	4	is	be	AUX
amwa-142	79	5	a	a	DET
amwa-142	79	6	choice	choice	NOUN
amwa-142	79	7	,	,	PUNCT
amwa-142	79	8	whether	whether	SCONJ
amwa-142	79	9	by	by	ADP
amwa-142	79	10	a	a	DET
amwa-142	79	11	doctor	doctor	NOUN
amwa-142	79	12	or	or	CCONJ
amwa-142	79	13	the	the	DET
amwa-142	79	14	patient	patient	NOUN
amwa-142	79	15	,	,	PUNCT
amwa-142	79	16	groups	group	NOUN
amwa-142	79	17	of	of	ADP
amwa-142	79	18	patients	patient	NOUN
amwa-142	79	19	taking	take	VERB
amwa-142	79	20	different	different	ADJ
amwa-142	79	21	treatments	treatment	NOUN
amwa-142	79	22	are	be	AUX
amwa-142	79	23	likely	likely	ADJ
amwa-142	79	24	to	to	PART
amwa-142	79	25	differ	differ	VERB
amwa-142	79	26	systematically	systematically	ADV
amwa-142	79	27	,	,	PUNCT
amwa-142	79	28	often	often	ADV
amwa-142	79	29	in	in	ADP
amwa-142	79	30	ways	way	NOUN
amwa-142	79	31	that	that	PRON
amwa-142	79	32	are	be	AUX
amwa-142	79	33	difficult	difficult	ADJ
amwa-142	79	34	to	to	PART
amwa-142	79	35	identify	identify	VERB
amwa-142	79	36	.	.	PUNCT
amwa-142	80	1	moreover	moreover	ADV
amwa-142	80	2	,	,	PUNCT
amwa-142	80	3	the	the	DET
amwa-142	80	4	reasons	reason	NOUN
amwa-142	80	5	for	for	ADP
amwa-142	80	6	the	the	DET
amwa-142	80	7	choice	choice	NOUN
amwa-142	80	8	of	of	ADP
amwa-142	80	9	a	a	DET
amwa-142	80	10	particular	particular	ADJ
amwa-142	80	11	treatment	treatment	NOUN
amwa-142	80	12	are	be	AUX
amwa-142	80	13	almost	almost	ADV
amwa-142	80	14	never	never	ADV
amwa-142	80	15	entered	enter	VERB
amwa-142	80	16	into	into	ADP
amwa-142	80	17	health	health	NOUN
amwa-142	80	18	records	record	NOUN
amwa-142	80	19	or	or	CCONJ
amwa-142	80	20	databases	database	NOUN
amwa-142	80	21	.	.	PUNCT
amwa-142	81	1	this	this	PRON
amwa-142	81	2	is	be	AUX
amwa-142	81	3	likely	likely	ADJ
amwa-142	81	4	to	to	PART
amwa-142	81	5	result	result	VERB
amwa-142	81	6	in	in	ADP
amwa-142	81	7	a	a	DET
amwa-142	81	8	biased	biased	ADJ
amwa-142	81	9	comparison	comparison	NOUN
amwa-142	81	10	of	of	ADP
amwa-142	81	11	the	the	DET
amwa-142	81	12	treatments	treatment	NOUN
amwa-142	81	13	.	.	PUNCT
amwa-142	82	1	indeed	indeed	ADV
amwa-142	82	2	,	,	PUNCT
amwa-142	82	3	there	there	PRON
amwa-142	82	4	have	have	AUX
amwa-142	82	5	been	be	AUX
amwa-142	82	6	well	well	ADV
amwa-142	82	7	-	-	PUNCT
amwa-142	82	8	publicized	publicize	VERB
amwa-142	82	9	cases	case	NOUN
amwa-142	82	10	in	in	ADP
amwa-142	82	11	which	which	PRON
amwa-142	82	12	observational	observational	ADJ
amwa-142	82	13	studies	study	NOUN
amwa-142	82	14	and	and	CCONJ
amwa-142	82	15	rcts	rct	NOUN
amwa-142	82	16	have	have	AUX
amwa-142	82	17	come	come	VERB
amwa-142	82	18	to	to	ADP
amwa-142	82	19	opposing	oppose	VERB
amwa-142	82	20	conclusions	conclusion	NOUN
amwa-142	82	21	about	about	ADP
amwa-142	82	22	particular	particular	ADJ
amwa-142	82	23	treatments	treatment	NOUN
amwa-142	82	24	.	.	PUNCT
amwa-142	83	1	an	an	DET
amwa-142	83	2	obstacle	obstacle	NOUN
amwa-142	83	3	to	to	ADP
amwa-142	83	4	using	use	VERB
amwa-142	83	5	rwd	rwd	NOUN
amwa-142	83	6	to	to	PART
amwa-142	83	7	evaluate	evaluate	VERB
amwa-142	83	8	effectiveness	effectiveness	NOUN
amwa-142	83	9	is	be	AUX
amwa-142	83	10	that	that	SCONJ
amwa-142	83	11	these	these	DET
amwa-142	83	12	data	datum	NOUN
amwa-142	83	13	originate	originate	VERB
amwa-142	83	14	in	in	ADP
amwa-142	83	15	routine	routine	ADJ
amwa-142	83	16	health	health	NOUN
amwa-142	83	17	care	care	NOUN
amwa-142	83	18	contexts	context	NOUN
amwa-142	83	19	in	in	ADP
amwa-142	83	20	which	which	PRON
amwa-142	83	21	patients	patient	NOUN
amwa-142	83	22	are	be	AUX
amwa-142	83	23	not	not	PART
amwa-142	83	24	randomized	randomize	VERB
amwa-142	83	25	to	to	ADP
amwa-142	83	26	treatments	treatment	NOUN
amwa-142	83	27	.	.	PUNCT
amwa-142	84	1	although	although	SCONJ
amwa-142	84	2	such	such	ADJ
amwa-142	84	3	data	datum	NOUN
amwa-142	84	4	have	have	AUX
amwa-142	84	5	long	long	ADV
amwa-142	84	6	been	be	AUX
amwa-142	84	7	used	use	VERB
amwa-142	84	8	by	by	ADP
amwa-142	84	9	regulators	regulator	NOUN
amwa-142	84	10	to	to	PART
amwa-142	84	11	evaluate	evaluate	VERB
amwa-142	84	12	the	the	DET
amwa-142	84	13	safety	safety	NOUN
amwa-142	84	14	of	of	ADP
amwa-142	84	15	treatments	treatment	NOUN
amwa-142	84	16	,	,	PUNCT
amwa-142	84	17	using	use	VERB
amwa-142	84	18	them	they	PRON
amwa-142	84	19	to	to	PART
amwa-142	84	20	arrive	arrive	VERB
amwa-142	84	21	at	at	ADP
amwa-142	84	22	unbiased	unbiased	ADJ
amwa-142	84	23	evaluations	evaluation	NOUN
amwa-142	84	24	of	of	ADP
amwa-142	84	25	effectiveness	effectiveness	NOUN
amwa-142	84	26	is	be	AUX
amwa-142	84	27	challenging	challenge	VERB
amwa-142	84	28	and	and	CCONJ
amwa-142	84	29	requires	require	VERB
amwa-142	84	30	sophisticated	sophisticated	ADJ
amwa-142	84	31	considerations	consideration	NOUN
amwa-142	84	32	on	on	ADP
amwa-142	84	33	methodology	methodology	NOUN
amwa-142	84	34	.	.	PUNCT
amwa-142	85	1	in	in	ADP
amwa-142	85	2	recent	recent	ADJ
amwa-142	85	3	years	year	NOUN
amwa-142	85	4	,	,	PUNCT
amwa-142	85	5	statisticians	statistician	NOUN
amwa-142	85	6	have	have	AUX
amwa-142	85	7	worked	work	VERB
amwa-142	85	8	on	on	ADP
amwa-142	85	9	developing	develop	VERB
amwa-142	85	10	new	new	ADJ
amwa-142	85	11	study	study	NOUN
amwa-142	85	12	designs	design	NOUN
amwa-142	85	13	and	and	CCONJ
amwa-142	85	14	complex	complex	ADJ
amwa-142	85	15	analysis	analysis	NOUN
amwa-142	85	16	methods	method	NOUN
amwa-142	85	17	,	,	PUNCT
amwa-142	85	18	including	include	VERB
amwa-142	85	19	so	so	ADV
amwa-142	85	20	-	-	PUNCT
amwa-142	85	21	called	call	VERB
amwa-142	85	22	“	"	PUNCT
amwa-142	85	23	causal	causal	ADJ
amwa-142	85	24	inference	inference	NOUN
amwa-142	85	25	”	"	PUNCT
amwa-142	85	26	and	and	CCONJ
amwa-142	85	27	machine	machine	NOUN
amwa-142	85	28	-	-	PUNCT
amwa-142	85	29	learning	learn	VERB
amwa-142	85	30	methods	method	NOUN
amwa-142	85	31	,	,	PUNCT
amwa-142	85	32	to	to	PART
amwa-142	85	33	help	help	VERB
amwa-142	85	34	overcome	overcome	VERB
amwa-142	85	35	some	some	PRON
amwa-142	85	36	of	of	ADP
amwa-142	85	37	the	the	DET
amwa-142	85	38	limitations	limitation	NOUN
amwa-142	85	39	of	of	ADP
amwa-142	85	40	analyzing	analyze	VERB
amwa-142	85	41	observational	observational	ADJ
amwa-142	85	42	data	datum	NOUN
amwa-142	85	43	.	.	PUNCT
amwa-142	86	1	the	the	DET
amwa-142	86	2	fda	fda	PROPN
amwa-142	86	3	has	have	AUX
amwa-142	86	4	committed	commit	VERB
amwa-142	86	5	(	(	PUNCT
amwa-142	86	6	in	in	ADP
amwa-142	86	7	its	its	PRON
amwa-142	86	8	rwe	rwe	PROPN
amwa-142	86	9	framework	framework	NOUN
amwa-142	86	10	document	document	NOUN
amwa-142	86	11	)	)	PUNCT
amwa-142	86	12	to	to	ADP
amwa-142	86	13	evaluating	evaluate	VERB
amwa-142	86	14	“	"	PUNCT
amwa-142	86	15	the	the	DET
amwa-142	86	16	potential	potential	ADJ
amwa-142	86	17	role	role	NOUN
amwa-142	86	18	of	of	ADP
amwa-142	86	19	observational	observational	ADJ
amwa-142	86	20	studies	study	NOUN
amwa-142	86	21	in	in	ADP
amwa-142	86	22	contributing	contribute	VERB
amwa-142	86	23	to	to	ADP
amwa-142	86	24	evidence	evidence	NOUN
amwa-142	86	25	of	of	ADP
amwa-142	86	26	drug	drug	NOUN
amwa-142	86	27	product	product	NOUN
amwa-142	86	28	effectiveness	effectiveness	NOUN
amwa-142	86	29	”	"	PUNCT
amwa-142	86	30	and	and	CCONJ
amwa-142	86	31	has	have	AUX
amwa-142	86	32	supported	support	VERB
amwa-142	86	33	a	a	DET
amwa-142	86	34	series	series	NOUN
amwa-142	86	35	of	of	ADP
amwa-142	86	36	workshops	workshop	NOUN
amwa-142	86	37	that	that	PRON
amwa-142	86	38	included	include	VERB
amwa-142	86	39	discussion	discussion	NOUN
amwa-142	86	40	of	of	ADP
amwa-142	86	41	methods	method	NOUN
amwa-142	86	42	for	for	ADP
amwa-142	86	43	assessing	assess	VERB
amwa-142	86	44	and	and	CCONJ
amwa-142	86	45	minimizing	minimize	VERB
amwa-142	86	46	bias	bias	NOUN
amwa-142	86	47	in	in	ADP
amwa-142	86	48	observational	observational	ADJ
amwa-142	86	49	studies	study	NOUN
amwa-142	86	50	.	.	PUNCT
amwa-142	87	1	statistically	statistically	ADV
amwa-142	87	2	speaking	speak	VERB
amwa-142	87	3	table	table	NOUN
amwa-142	87	4	1	1	NUM
amwa-142	87	5	.	.	PUNCT
amwa-142	87	6	real	real	ADJ
amwa-142	87	7	-	-	PUNCT
amwa-142	87	8	world	world	NOUN
amwa-142	87	9	data	datum	NOUN
amwa-142	87	10	:	:	PUNCT
amwa-142	87	11	common	common	ADJ
amwa-142	87	12	problems	problem	NOUN
amwa-142	87	13	with	with	ADP
amwa-142	87	14	data	datum	NOUN
amwa-142	87	15	quality	quality	NOUN
amwa-142	87	16	characteristic	characteristic	NOUN
amwa-142	87	17	of	of	ADP
amwa-142	87	18	data	datum	NOUN
amwa-142	87	19	likely	likely	ADJ
amwa-142	87	20	problems	problem	NOUN
amwa-142	87	21	with	with	ADP
amwa-142	87	22	rwd	rwd	NOUN
amwa-142	87	23	relevance	relevance	NOUN
amwa-142	87	24	to	to	PART
amwa-142	87	25	research	research	VERB
amwa-142	87	26	questions	question	NOUN
amwa-142	87	27	data	datum	NOUN
amwa-142	87	28	are	be	AUX
amwa-142	87	29	collected	collect	VERB
amwa-142	87	30	for	for	ADP
amwa-142	87	31	purposes	purpose	NOUN
amwa-142	87	32	other	other	ADJ
amwa-142	87	33	than	than	ADP
amwa-142	87	34	research	research	NOUN
amwa-142	87	35	and	and	CCONJ
amwa-142	87	36	will	will	AUX
amwa-142	87	37	not	not	PART
amwa-142	87	38	be	be	AUX
amwa-142	87	39	optimal	optimal	ADJ
amwa-142	87	40	for	for	ADP
amwa-142	87	41	answering	answer	VERB
amwa-142	87	42	the	the	DET
amwa-142	87	43	question	question	NOUN
amwa-142	87	44	of	of	ADP
amwa-142	87	45	interest	interest	NOUN
amwa-142	87	46	.	.	PUNCT
amwa-142	88	1	there	there	PRON
amwa-142	88	2	is	be	VERB
amwa-142	88	3	a	a	DET
amwa-142	88	4	risk	risk	NOUN
amwa-142	88	5	of	of	ADP
amwa-142	88	6	allowing	allow	VERB
amwa-142	88	7	the	the	DET
amwa-142	88	8	available	available	ADJ
amwa-142	88	9	data	datum	NOUN
amwa-142	88	10	to	to	PART
amwa-142	88	11	determine	determine	VERB
amwa-142	88	12	the	the	DET
amwa-142	88	13	research	research	NOUN
amwa-142	88	14	questions	question	NOUN
amwa-142	88	15	that	that	PRON
amwa-142	88	16	are	be	AUX
amwa-142	88	17	asked	ask	VERB
amwa-142	88	18	(	(	PUNCT
amwa-142	88	19	rather	rather	ADV
amwa-142	88	20	than	than	ADP
amwa-142	88	21	defining	define	VERB
amwa-142	88	22	the	the	DET
amwa-142	88	23	question	question	NOUN
amwa-142	88	24	first	first	ADV
amwa-142	88	25	and	and	CCONJ
amwa-142	88	26	then	then	ADV
amwa-142	88	27	looking	look	VERB
amwa-142	88	28	for	for	ADP
amwa-142	88	29	the	the	DET
amwa-142	88	30	data	datum	NOUN
amwa-142	88	31	)	)	PUNCT
amwa-142	88	32	.	.	PUNCT
amwa-142	89	1	reliability	reliability	NOUN
amwa-142	89	2	inaccuracies	inaccuracy	NOUN
amwa-142	89	3	in	in	ADP
amwa-142	89	4	the	the	DET
amwa-142	89	5	data	datum	NOUN
amwa-142	89	6	may	may	AUX
amwa-142	89	7	result	result	VERB
amwa-142	89	8	from	from	ADP
amwa-142	89	9	human	human	ADJ
amwa-142	89	10	error	error	NOUN
amwa-142	89	11	or	or	CCONJ
amwa-142	89	12	faulty	faulty	ADJ
amwa-142	89	13	devices	device	NOUN
amwa-142	89	14	.	.	PUNCT
amwa-142	90	1	data	datum	NOUN
amwa-142	90	2	collected	collect	VERB
amwa-142	90	3	can	can	AUX
amwa-142	90	4	not	not	PART
amwa-142	90	5	be	be	AUX
amwa-142	90	6	verified	verify	VERB
amwa-142	90	7	by	by	ADP
amwa-142	90	8	comparison	comparison	NOUN
amwa-142	90	9	with	with	ADP
amwa-142	90	10	source	source	NOUN
amwa-142	90	11	data	datum	NOUN
amwa-142	90	12	.	.	PUNCT
amwa-142	91	1	random	random	ADJ
amwa-142	91	2	errors	error	NOUN
amwa-142	91	3	and	and	CCONJ
amwa-142	91	4	systematic	systematic	ADJ
amwa-142	91	5	bias	bias	NOUN
amwa-142	91	6	are	be	AUX
amwa-142	91	7	difficult	difficult	ADJ
amwa-142	91	8	to	to	PART
amwa-142	91	9	identify	identify	VERB
amwa-142	91	10	and	and	CCONJ
amwa-142	91	11	impossible	impossible	ADJ
amwa-142	91	12	to	to	PART
amwa-142	91	13	correct	correct	VERB
amwa-142	91	14	.	.	PUNCT
amwa-142	92	1	completeness	completeness	NOUN
amwa-142	92	2	rwd	rwd	NOUN
amwa-142	92	3	are	be	AUX
amwa-142	92	4	characterized	characterize	VERB
amwa-142	92	5	by	by	ADP
amwa-142	92	6	a	a	DET
amwa-142	92	7	high	high	ADJ
amwa-142	92	8	quantity	quantity	NOUN
amwa-142	92	9	of	of	ADP
amwa-142	92	10	missing	miss	VERB
amwa-142	92	11	values	value	NOUN
amwa-142	92	12	,	,	PUNCT
amwa-142	92	13	with	with	ADP
amwa-142	92	14	no	no	DET
amwa-142	92	15	information	information	NOUN
amwa-142	92	16	as	as	ADP
amwa-142	92	17	to	to	ADP
amwa-142	92	18	why	why	SCONJ
amwa-142	92	19	data	datum	NOUN
amwa-142	92	20	are	be	AUX
amwa-142	92	21	missing	miss	VERB
amwa-142	92	22	.	.	PUNCT
amwa-142	93	1	consistency	consistency	NOUN
amwa-142	93	2	and	and	CCONJ
amwa-142	93	3	interoperability	interoperability	NOUN
amwa-142	93	4	variables	variable	NOUN
amwa-142	93	5	recorded	record	VERB
amwa-142	93	6	,	,	PUNCT
amwa-142	93	7	measurement	measurement	NOUN
amwa-142	93	8	methods	method	NOUN
amwa-142	93	9	,	,	PUNCT
amwa-142	93	10	and	and	CCONJ
amwa-142	93	11	data	datum	NOUN
amwa-142	93	12	formats	format	NOUN
amwa-142	93	13	and	and	CCONJ
amwa-142	93	14	data	datum	NOUN
amwa-142	93	15	standards	standard	NOUN
amwa-142	93	16	usually	usually	ADV
amwa-142	93	17	vary	vary	VERB
amwa-142	93	18	greatly	greatly	ADV
amwa-142	93	19	across	across	ADP
amwa-142	93	20	patients	patient	NOUN
amwa-142	93	21	,	,	PUNCT
amwa-142	93	22	health	health	NOUN
amwa-142	93	23	care	care	NOUN
amwa-142	93	24	providers	provider	NOUN
amwa-142	93	25	,	,	PUNCT
amwa-142	93	26	devices	device	NOUN
amwa-142	93	27	,	,	PUNCT
amwa-142	93	28	companies	company	NOUN
amwa-142	93	29	,	,	PUNCT
amwa-142	93	30	etc	etc	X
amwa-142	93	31	.	.	X
amwa-142	94	1	the	the	DET
amwa-142	94	2	lack	lack	NOUN
amwa-142	94	3	of	of	ADP
amwa-142	94	4	common	common	ADJ
amwa-142	94	5	data	datum	NOUN
amwa-142	94	6	standards	standard	NOUN
amwa-142	94	7	,	,	PUNCT
amwa-142	94	8	ie	ie	X
amwa-142	94	9	,	,	PUNCT
amwa-142	94	10	the	the	DET
amwa-142	94	11	way	way	NOUN
amwa-142	94	12	data	datum	NOUN
amwa-142	94	13	are	be	AUX
amwa-142	94	14	structured	structure	VERB
amwa-142	94	15	,	,	PUNCT
amwa-142	94	16	stored	store	VERB
amwa-142	94	17	,	,	PUNCT
amwa-142	94	18	and	and	CCONJ
amwa-142	94	19	summarized	summarize	VERB
amwa-142	94	20	,	,	PUNCT
amwa-142	94	21	makes	make	VERB
amwa-142	94	22	it	it	PRON
amwa-142	94	23	challenging	challenge	VERB
amwa-142	94	24	to	to	PART
amwa-142	94	25	collate	collate	VERB
amwa-142	94	26	and	and	CCONJ
amwa-142	94	27	analyze	analyze	VERB
amwa-142	94	28	the	the	DET
amwa-142	94	29	data	datum	NOUN
amwa-142	94	30	.	.	PUNCT
amwa-142	95	1	amwa	amwa	PROPN
amwa-142	95	2	journal	journal	PROPN
amwa-142	95	3	/	/	SYM
amwa-142	95	4	v36	v36	PROPN
amwa-142	95	5	n1	n1	PROPN
amwa-142	95	6	/	/	SYM
amwa-142	95	7	2021	2021	NUM
amwa-142	95	8	/	/	SYM
amwa-142	95	9	amwa.org	amwa.org	PROPN
amwa-142	95	10	37	37	NUM
amwa-142	95	11	obstacle	obstacle	NOUN
amwa-142	95	12	3	3	NUM
amwa-142	95	13	:	:	PUNCT
amwa-142	95	14	the	the	DET
amwa-142	95	15	need	need	NOUN
amwa-142	95	16	for	for	ADP
amwa-142	95	17	rigorous	rigorous	ADJ
amwa-142	95	18	research	research	NOUN
amwa-142	95	19	methodology	methodology	NOUN
amwa-142	95	20	no	no	DET
amwa-142	95	21	amount	amount	NOUN
amwa-142	95	22	of	of	ADP
amwa-142	95	23	data	datum	NOUN
amwa-142	95	24	can	can	AUX
amwa-142	95	25	,	,	PUNCT
amwa-142	95	26	in	in	ADP
amwa-142	95	27	itself	itself	PRON
amwa-142	95	28	,	,	PUNCT
amwa-142	95	29	help	help	VERB
amwa-142	95	30	us	we	PRON
amwa-142	95	31	evaluate	evaluate	VERB
amwa-142	95	32	treatments	treatment	NOUN
amwa-142	95	33	.	.	PUNCT
amwa-142	96	1	data	datum	NOUN
amwa-142	96	2	only	only	ADV
amwa-142	96	3	become	become	VERB
amwa-142	96	4	evidence	evidence	NOUN
amwa-142	96	5	once	once	SCONJ
amwa-142	96	6	they	they	PRON
amwa-142	96	7	are	be	AUX
amwa-142	96	8	used	use	VERB
amwa-142	96	9	within	within	ADP
amwa-142	96	10	a	a	DET
amwa-142	96	11	methodological	methodological	ADJ
amwa-142	96	12	framework	framework	NOUN
amwa-142	96	13	or	or	CCONJ
amwa-142	96	14	research	research	NOUN
amwa-142	96	15	study	study	NOUN
amwa-142	96	16	to	to	PART
amwa-142	96	17	answer	answer	VERB
amwa-142	96	18	specific	specific	ADJ
amwa-142	96	19	questions	question	NOUN
amwa-142	96	20	,	,	PUNCT
amwa-142	96	21	such	such	ADJ
amwa-142	96	22	as	as	ADP
amwa-142	96	23	“	"	PUNCT
amwa-142	96	24	is	be	AUX
amwa-142	96	25	treatment	treatment	NOUN
amwa-142	96	26	x	x	SYM
amwa-142	96	27	effective	effective	ADJ
amwa-142	96	28	in	in	ADP
amwa-142	96	29	patients	patient	NOUN
amwa-142	96	30	with	with	ADP
amwa-142	96	31	heart	heart	NOUN
amwa-142	96	32	failure	failure	NOUN
amwa-142	96	33	?	?	PUNCT
amwa-142	96	34	”	"	PUNCT
amwa-142	96	35	or	or	CCONJ
amwa-142	96	36	“	"	PUNCT
amwa-142	96	37	how	how	SCONJ
amwa-142	96	38	much	much	ADV
amwa-142	96	39	more	more	ADV
amwa-142	96	40	effective	effective	ADJ
amwa-142	96	41	is	be	AUX
amwa-142	96	42	treatment	treatment	NOUN
amwa-142	96	43	a	a	PRON
amwa-142	96	44	than	than	ADP
amwa-142	96	45	treatment	treatment	NOUN
amwa-142	96	46	b	b	NOUN
amwa-142	96	47	at	at	ADP
amwa-142	96	48	extending	extend	VERB
amwa-142	96	49	survival	survival	NOUN
amwa-142	96	50	in	in	ADP
amwa-142	96	51	patients	patient	NOUN
amwa-142	96	52	with	with	ADP
amwa-142	96	53	advanced	advanced	ADJ
amwa-142	96	54	non	non	ADJ
amwa-142	96	55	-	-	ADJ
amwa-142	96	56	small	small	ADJ
amwa-142	96	57	cell	cell	NOUN
amwa-142	96	58	lung	lung	NOUN
amwa-142	96	59	cancer	cancer	NOUN
amwa-142	96	60	?	?	PUNCT
amwa-142	96	61	”	"	PUNCT
amwa-142	97	1	for	for	SCONJ
amwa-142	97	2	rwd	rwd	NOUN
amwa-142	97	3	to	to	PART
amwa-142	97	4	provide	provide	VERB
amwa-142	97	5	evidence	evidence	NOUN
amwa-142	97	6	of	of	ADP
amwa-142	97	7	effectiveness	effectiveness	NOUN
amwa-142	97	8	,	,	PUNCT
amwa-142	97	9	they	they	PRON
amwa-142	97	10	need	need	VERB
amwa-142	97	11	to	to	PART
amwa-142	97	12	be	be	AUX
amwa-142	97	13	analyzed	analyze	VERB
amwa-142	97	14	using	use	VERB
amwa-142	97	15	an	an	DET
amwa-142	97	16	appropriate	appropriate	ADJ
amwa-142	97	17	research	research	NOUN
amwa-142	97	18	methodology	methodology	NOUN
amwa-142	97	19	.	.	PUNCT
amwa-142	98	1	this	this	PRON
amwa-142	98	2	includes	include	VERB
amwa-142	98	3	the	the	DET
amwa-142	98	4	definition	definition	NOUN
amwa-142	98	5	of	of	ADP
amwa-142	98	6	data	datum	NOUN
amwa-142	98	7	formats	format	NOUN
amwa-142	98	8	for	for	ADP
amwa-142	98	9	datasets	dataset	NOUN
amwa-142	98	10	,	,	PUNCT
amwa-142	98	11	the	the	DET
amwa-142	98	12	availability	availability	NOUN
amwa-142	98	13	of	of	ADP
amwa-142	98	14	a	a	DET
amwa-142	98	15	comprehensive	comprehensive	ADJ
amwa-142	98	16	study	study	NOUN
amwa-142	98	17	protocol	protocol	NOUN
amwa-142	98	18	,	,	PUNCT
amwa-142	98	19	and	and	CCONJ
amwa-142	98	20	detailed	detailed	ADJ
amwa-142	98	21	analysis	analysis	NOUN
amwa-142	98	22	plans	plan	VERB
amwa-142	98	23	to	to	PART
amwa-142	98	24	ensure	ensure	VERB
amwa-142	98	25	reproducibility	reproducibility	NOUN
amwa-142	98	26	of	of	ADP
amwa-142	98	27	results	result	NOUN
amwa-142	98	28	.	.	PUNCT
amwa-142	99	1	if	if	SCONJ
amwa-142	99	2	data	datum	NOUN
amwa-142	99	3	are	be	AUX
amwa-142	99	4	derived	derive	VERB
amwa-142	99	5	from	from	ADP
amwa-142	99	6	novel	novel	ADJ
amwa-142	99	7	data	datum	NOUN
amwa-142	99	8	sources	source	NOUN
amwa-142	99	9	such	such	ADJ
amwa-142	99	10	as	as	ADP
amwa-142	99	11	wearables	wearable	NOUN
amwa-142	99	12	,	,	PUNCT
amwa-142	99	13	these	these	DET
amwa-142	99	14	data	datum	NOUN
amwa-142	99	15	need	need	VERB
amwa-142	99	16	to	to	PART
amwa-142	99	17	accurately	accurately	ADV
amwa-142	99	18	reflect	reflect	VERB
amwa-142	99	19	the	the	DET
amwa-142	99	20	clinical	clinical	ADJ
amwa-142	99	21	outcome	outcome	NOUN
amwa-142	99	22	that	that	PRON
amwa-142	99	23	is	be	AUX
amwa-142	99	24	being	be	AUX
amwa-142	99	25	investigated	investigate	VERB
amwa-142	99	26	.	.	PUNCT
amwa-142	100	1	combining	combine	VERB
amwa-142	100	2	clinical	clinical	ADJ
amwa-142	100	3	trials	trial	NOUN
amwa-142	100	4	and	and	CCONJ
amwa-142	100	5	real	real	ADJ
amwa-142	100	6	-	-	PUNCT
amwa-142	100	7	world	world	NOUN
amwa-142	100	8	data	datum	NOUN
amwa-142	100	9	for	for	ADP
amwa-142	100	10	insight	insight	NOUN
amwa-142	100	11	into	into	ADP
amwa-142	100	12	effectiveness	effectiveness	NOUN
amwa-142	100	13	observational	observational	ADJ
amwa-142	100	14	studies	study	NOUN
amwa-142	100	15	are	be	AUX
amwa-142	100	16	not	not	PART
amwa-142	100	17	the	the	DET
amwa-142	100	18	only	only	ADJ
amwa-142	100	19	way	way	NOUN
amwa-142	100	20	of	of	ADP
amwa-142	100	21	using	use	VERB
amwa-142	100	22	rwd	rwd	NOUN
amwa-142	100	23	to	to	PART
amwa-142	100	24	tackle	tackle	VERB
amwa-142	100	25	the	the	DET
amwa-142	100	26	question	question	NOUN
amwa-142	100	27	of	of	ADP
amwa-142	100	28	effectiveness	effectiveness	NOUN
amwa-142	100	29	.	.	PUNCT
amwa-142	101	1	a	a	DET
amwa-142	101	2	promising	promising	ADJ
amwa-142	101	3	alternative	alternative	ADJ
amwa-142	101	4	approach	approach	NOUN
amwa-142	101	5	advocated	advocate	VERB
amwa-142	101	6	in	in	ADP
amwa-142	101	7	the	the	DET
amwa-142	101	8	fda	fda	PROPN
amwa-142	101	9	framework	framework	NOUN
amwa-142	101	10	document	document	NOUN
amwa-142	101	11	as	as	ADP
amwa-142	101	12	a	a	DET
amwa-142	101	13	way	way	NOUN
amwa-142	101	14	of	of	ADP
amwa-142	101	15	generating	generate	VERB
amwa-142	101	16	rwe	rwe	PROPN
amwa-142	101	17	is	be	AUX
amwa-142	101	18	to	to	PART
amwa-142	101	19	make	make	VERB
amwa-142	101	20	clinical	clinical	ADJ
amwa-142	101	21	trials	trial	NOUN
amwa-142	101	22	more	more	ADJ
amwa-142	101	23	“	"	PUNCT
amwa-142	101	24	real	real	ADJ
amwa-142	101	25	life	life	NOUN
amwa-142	101	26	.	.	PUNCT
amwa-142	101	27	”	"	PUNCT
amwa-142	102	1	this	this	PRON
amwa-142	102	2	can	can	AUX
amwa-142	102	3	be	be	AUX
amwa-142	102	4	done	do	VERB
amwa-142	102	5	by	by	ADP
amwa-142	102	6	simplifying	simplify	VERB
amwa-142	102	7	the	the	DET
amwa-142	102	8	trial	trial	NOUN
amwa-142	102	9	design	design	NOUN
amwa-142	102	10	to	to	PART
amwa-142	102	11	become	become	VERB
amwa-142	102	12	a	a	DET
amwa-142	102	13	“	"	PUNCT
amwa-142	102	14	large	large	ADJ
amwa-142	102	15	,	,	PUNCT
amwa-142	102	16	simple	simple	ADJ
amwa-142	102	17	trial	trial	NOUN
amwa-142	102	18	”	"	PUNCT
amwa-142	102	19	or	or	CCONJ
amwa-142	102	20	by	by	ADP
amwa-142	102	21	otherwise	otherwise	ADV
amwa-142	102	22	incorporating	incorporate	VERB
amwa-142	102	23	pragmatic	pragmatic	ADJ
amwa-142	102	24	elements	element	NOUN
amwa-142	102	25	in	in	ADP
amwa-142	102	26	the	the	DET
amwa-142	102	27	design	design	NOUN
amwa-142	102	28	so	so	SCONJ
amwa-142	102	29	that	that	SCONJ
amwa-142	102	30	patients	patient	NOUN
amwa-142	102	31	’	'	PUNCT
amwa-142	102	32	treatment	treatment	NOUN
amwa-142	102	33	within	within	ADP
amwa-142	102	34	the	the	DET
amwa-142	102	35	trial	trial	NOUN
amwa-142	102	36	closely	closely	ADV
amwa-142	102	37	resembles	resemble	VERB
amwa-142	102	38	routine	routine	ADJ
amwa-142	102	39	clinical	clinical	ADJ
amwa-142	102	40	practice	practice	NOUN
amwa-142	102	41	(	(	PUNCT
amwa-142	102	42	figure	figure	NOUN
amwa-142	102	43	1	1	NUM
amwa-142	102	44	)	)	PUNCT
amwa-142	102	45	.	.	PUNCT
amwa-142	103	1	alternatively	alternatively	ADV
amwa-142	103	2	,	,	PUNCT
amwa-142	103	3	hybrid	hybrid	ADJ
amwa-142	103	4	designs	design	NOUN
amwa-142	103	5	can	can	AUX
amwa-142	103	6	be	be	AUX
amwa-142	103	7	used	use	VERB
amwa-142	103	8	whereby	whereby	SCONJ
amwa-142	103	9	health	health	NOUN
amwa-142	103	10	data	datum	NOUN
amwa-142	103	11	that	that	PRON
amwa-142	103	12	are	be	AUX
amwa-142	103	13	routinely	routinely	ADV
amwa-142	103	14	collected	collect	VERB
amwa-142	103	15	are	be	AUX
amwa-142	103	16	used	use	VERB
amwa-142	103	17	in	in	ADP
amwa-142	103	18	the	the	DET
amwa-142	103	19	trial	trial	NOUN
amwa-142	103	20	,	,	PUNCT
amwa-142	103	21	together	together	ADV
amwa-142	103	22	with	with	ADP
amwa-142	103	23	data	datum	NOUN
amwa-142	103	24	specified	specify	VERB
amwa-142	103	25	by	by	ADP
amwa-142	103	26	the	the	DET
amwa-142	103	27	trial	trial	NOUN
amwa-142	103	28	protocol	protocol	NOUN
amwa-142	103	29	(	(	PUNCT
amwa-142	103	30	for	for	ADP
amwa-142	103	31	example	example	NOUN
amwa-142	103	32	,	,	PUNCT
amwa-142	103	33	efficacy	efficacy	NOUN
amwa-142	103	34	-	-	PUNCT
amwa-142	103	35	to	to	ADP
amwa-142	103	36	-	-	PUNCT
amwa-142	103	37	effectiveness	effectiveness	NOUN
amwa-142	103	38	or	or	CCONJ
amwa-142	103	39	efficacy	efficacy	NOUN
amwa-142	103	40	-	-	PUNCT
amwa-142	103	41	and	and	CCONJ
amwa-142	103	42	-	-	PUNCT
amwa-142	103	43	effectiveness	effectiveness	NOUN
amwa-142	103	44	-	-	PUNCT
amwa-142	103	45	too	too	ADV
amwa-142	103	46	trials	trial	NOUN
amwa-142	103	47	)	)	PUNCT
amwa-142	103	48	.	.	PUNCT
amwa-142	104	1	combining	combine	VERB
amwa-142	104	2	clinical	clinical	ADJ
amwa-142	104	3	trial	trial	NOUN
amwa-142	104	4	methodology	methodology	NOUN
amwa-142	104	5	,	,	PUNCT
amwa-142	104	6	notably	notably	ADV
amwa-142	104	7	randomization	randomization	NOUN
amwa-142	104	8	,	,	PUNCT
amwa-142	104	9	with	with	SCONJ
amwa-142	104	10	the	the	DET
amwa-142	104	11	collection	collection	NOUN
amwa-142	104	12	and	and	CCONJ
amwa-142	104	13	evaluation	evaluation	NOUN
amwa-142	104	14	of	of	ADP
amwa-142	104	15	rwd	rwd	NOUN
amwa-142	104	16	has	have	VERB
amwa-142	104	17	the	the	DET
amwa-142	104	18	benefit	benefit	NOUN
amwa-142	104	19	of	of	ADP
amwa-142	104	20	enabling	enable	VERB
amwa-142	104	21	a	a	DET
amwa-142	104	22	more	more	ADV
amwa-142	104	23	unbiased	unbiased	ADJ
amwa-142	104	24	evaluation	evaluation	NOUN
amwa-142	104	25	of	of	ADP
amwa-142	104	26	treatment	treatment	NOUN
amwa-142	104	27	effects	effect	NOUN
amwa-142	104	28	in	in	ADP
amwa-142	104	29	settings	setting	NOUN
amwa-142	104	30	that	that	PRON
amwa-142	104	31	are	be	AUX
amwa-142	104	32	close	close	ADJ
amwa-142	104	33	to	to	ADP
amwa-142	104	34	real	real	ADJ
amwa-142	104	35	-	-	PUNCT
amwa-142	104	36	world	world	NOUN
amwa-142	104	37	clinical	clinical	ADJ
amwa-142	104	38	practice	practice	NOUN
amwa-142	104	39	.	.	PUNCT
amwa-142	105	1	particularly	particularly	ADV
amwa-142	105	2	in	in	ADP
amwa-142	105	3	rare	rare	ADJ
amwa-142	105	4	diseases	disease	NOUN
amwa-142	105	5	,	,	PUNCT
amwa-142	105	6	it	it	PRON
amwa-142	105	7	is	be	AUX
amwa-142	105	8	often	often	ADV
amwa-142	105	9	impossible	impossible	ADJ
amwa-142	105	10	to	to	PART
amwa-142	105	11	conduct	conduct	VERB
amwa-142	105	12	rcts	rct	NOUN
amwa-142	105	13	because	because	SCONJ
amwa-142	105	14	of	of	ADP
amwa-142	105	15	the	the	DET
amwa-142	105	16	low	low	ADJ
amwa-142	105	17	number	number	NOUN
amwa-142	105	18	of	of	ADP
amwa-142	105	19	patients	patient	NOUN
amwa-142	105	20	available	available	ADJ
amwa-142	105	21	.	.	PUNCT
amwa-142	106	1	recruiting	recruit	VERB
amwa-142	106	2	a	a	DET
amwa-142	106	3	sufficient	sufficient	ADJ
amwa-142	106	4	number	number	NOUN
amwa-142	106	5	of	of	ADP
amwa-142	106	6	patients	patient	NOUN
amwa-142	106	7	into	into	ADP
amwa-142	106	8	a	a	DET
amwa-142	106	9	study	study	NOUN
amwa-142	106	10	may	may	AUX
amwa-142	106	11	take	take	VERB
amwa-142	106	12	too	too	ADV
amwa-142	106	13	long	long	ADJ
amwa-142	106	14	to	to	PART
amwa-142	106	15	yield	yield	VERB
amwa-142	106	16	useful	useful	ADJ
amwa-142	106	17	results	result	NOUN
amwa-142	106	18	.	.	PUNCT
amwa-142	107	1	in	in	ADP
amwa-142	107	2	these	these	DET
amwa-142	107	3	instances	instance	NOUN
amwa-142	107	4	,	,	PUNCT
amwa-142	107	5	single	single	ADJ
amwa-142	107	6	-	-	PUNCT
amwa-142	107	7	arm	arm	NOUN
amwa-142	107	8	open	open	ADJ
amwa-142	107	9	-	-	PUNCT
amwa-142	107	10	label	label	NOUN
amwa-142	107	11	studies	study	NOUN
amwa-142	107	12	may	may	AUX
amwa-142	107	13	be	be	AUX
amwa-142	107	14	conducted	conduct	VERB
amwa-142	107	15	and	and	CCONJ
amwa-142	107	16	the	the	DET
amwa-142	107	17	results	result	NOUN
amwa-142	107	18	compared	compare	VERB
amwa-142	107	19	with	with	ADP
amwa-142	107	20	external	external	ADJ
amwa-142	107	21	controls	control	NOUN
amwa-142	107	22	,	,	PUNCT
amwa-142	107	23	ie	ie	X
amwa-142	107	24	,	,	PUNCT
amwa-142	107	25	rwd	rwd	NOUN
amwa-142	107	26	collected	collect	VERB
amwa-142	107	27	outside	outside	ADV
amwa-142	107	28	of	of	ADP
amwa-142	107	29	the	the	DET
amwa-142	107	30	study	study	NOUN
amwa-142	107	31	.	.	PUNCT
amwa-142	108	1	the	the	DET
amwa-142	108	2	control	control	NOUN
amwa-142	108	3	data	datum	NOUN
amwa-142	108	4	could	could	AUX
amwa-142	108	5	come	come	VERB
amwa-142	108	6	from	from	ADP
amwa-142	108	7	registries	registry	NOUN
amwa-142	108	8	,	,	PUNCT
amwa-142	108	9	medical	medical	ADJ
amwa-142	108	10	records	record	NOUN
amwa-142	108	11	,	,	PUNCT
amwa-142	108	12	scientific	scientific	ADJ
amwa-142	108	13	literature	literature	NOUN
amwa-142	108	14	,	,	PUNCT
amwa-142	108	15	or	or	CCONJ
amwa-142	108	16	expanded	expand	VERB
amwa-142	108	17	access	access	NOUN
amwa-142	108	18	programs	program	NOUN
amwa-142	108	19	.	.	PUNCT
amwa-142	109	1	a	a	DET
amwa-142	109	2	recent	recent	ADJ
amwa-142	109	3	example	example	NOUN
amwa-142	109	4	of	of	ADP
amwa-142	109	5	such	such	DET
amwa-142	109	6	an	an	DET
amwa-142	109	7	approach	approach	NOUN
amwa-142	109	8	is	be	AUX
amwa-142	109	9	the	the	DET
amwa-142	109	10	approval	approval	NOUN
amwa-142	109	11	of	of	ADP
amwa-142	109	12	avelumab	avelumab	NOUN
amwa-142	109	13	in	in	ADP
amwa-142	109	14	metastatic	metastatic	ADJ
amwa-142	109	15	merkel	merkel	NOUN
amwa-142	109	16	cell	cell	NOUN
amwa-142	109	17	carcinoma	carcinoma	NOUN
amwa-142	109	18	.	.	PUNCT
amwa-142	110	1	the	the	DET
amwa-142	110	2	drug	drug	NOUN
amwa-142	110	3	was	be	AUX
amwa-142	110	4	approved	approve	VERB
amwa-142	110	5	in	in	ADP
amwa-142	110	6	2017	2017	NUM
amwa-142	110	7	based	base	VERB
amwa-142	110	8	on	on	ADP
amwa-142	110	9	a	a	DET
amwa-142	110	10	single	single	ADJ
amwa-142	110	11	-	-	PUNCT
amwa-142	110	12	arm	arm	NOUN
amwa-142	110	13	open	open	ADJ
amwa-142	110	14	-	-	PUNCT
amwa-142	110	15	label	label	NOUN
amwa-142	110	16	study	study	NOUN
amwa-142	110	17	that	that	PRON
amwa-142	110	18	compared	compare	VERB
amwa-142	110	19	the	the	DET
amwa-142	110	20	study	study	NOUN
amwa-142	110	21	outcomes	outcome	NOUN
amwa-142	110	22	with	with	ADP
amwa-142	110	23	historical	historical	ADJ
amwa-142	110	24	controls	control	NOUN
amwa-142	110	25	retrieved	retrieve	VERB
amwa-142	110	26	from	from	ADP
amwa-142	110	27	electronic	electronic	ADJ
amwa-142	110	28	health	health	NOUN
amwa-142	110	29	records	record	NOUN
amwa-142	110	30	.	.	PUNCT
amwa-142	111	1	in	in	ADP
amwa-142	111	2	2019	2019	NUM
amwa-142	111	3	,	,	PUNCT
amwa-142	111	4	approval	approval	NOUN
amwa-142	111	5	of	of	ADP
amwa-142	111	6	palbociclib	palbociclib	NOUN
amwa-142	111	7	for	for	ADP
amwa-142	111	8	hr+	hr+	PROPN
amwa-142	111	9	,	,	PUNCT
amwa-142	111	10	her2advanced	her2advanced	ADJ
amwa-142	111	11	breast	breast	NOUN
amwa-142	111	12	cancer	cancer	NOUN
amwa-142	111	13	in	in	ADP
amwa-142	111	14	men	man	NOUN
amwa-142	111	15	,	,	PUNCT
amwa-142	111	16	a	a	DET
amwa-142	111	17	label	label	NOUN
amwa-142	111	18	extension	extension	NOUN
amwa-142	111	19	,	,	PUNCT
amwa-142	111	20	was	be	AUX
amwa-142	111	21	based	base	VERB
amwa-142	111	22	on	on	ADP
amwa-142	111	23	post	post	ADJ
amwa-142	111	24	-	-	ADJ
amwa-142	111	25	marketing	marketing	ADJ
amwa-142	111	26	reports	report	NOUN
amwa-142	111	27	and	and	CCONJ
amwa-142	111	28	electronic	electronic	ADJ
amwa-142	111	29	health	health	NOUN
amwa-142	111	30	records	record	NOUN
amwa-142	111	31	.	.	PUNCT
amwa-142	112	1	responses	response	NOUN
amwa-142	112	2	to	to	ADP
amwa-142	112	3	the	the	DET
amwa-142	112	4	coronavirus	coronavirus	NOUN
amwa-142	112	5	disease	disease	NOUN
amwa-142	112	6	2019	2019	NUM
amwa-142	112	7	(	(	PUNCT
amwa-142	112	8	covid-19	covid-19	PROPN
amwa-142	112	9	)	)	PUNCT
amwa-142	112	10	pandemic	pandemic	NOUN
amwa-142	112	11	provide	provide	VERB
amwa-142	112	12	a	a	DET
amwa-142	112	13	further	further	ADJ
amwa-142	112	14	,	,	PUNCT
amwa-142	112	15	highly	highly	ADV
amwa-142	112	16	topical	topical	ADJ
amwa-142	112	17	example	example	NOUN
amwa-142	112	18	of	of	ADP
amwa-142	112	19	how	how	SCONJ
amwa-142	112	20	randomized	randomized	ADJ
amwa-142	112	21	trials	trial	NOUN
amwa-142	112	22	that	that	PRON
amwa-142	112	23	incorporate	incorporate	VERB
amwa-142	112	24	real	real	ADJ
amwa-142	112	25	-	-	PUNCT
amwa-142	112	26	world	world	NOUN
amwa-142	112	27	elements	element	NOUN
amwa-142	112	28	can	can	AUX
amwa-142	112	29	generate	generate	VERB
amwa-142	112	30	reliable	reliable	ADJ
amwa-142	112	31	evidence	evidence	NOUN
amwa-142	112	32	of	of	ADP
amwa-142	112	33	effectiveness	effectiveness	NOUN
amwa-142	112	34	to	to	PART
amwa-142	112	35	guide	guide	VERB
amwa-142	112	36	clinical	clinical	ADJ
amwa-142	112	37	decision	decision	NOUN
amwa-142	112	38	-	-	PUNCT
amwa-142	112	39	making	making	NOUN
amwa-142	112	40	about	about	ADP
amwa-142	112	41	treatments	treatment	NOUN
amwa-142	112	42	.	.	PUNCT
amwa-142	113	1	at	at	ADP
amwa-142	113	2	the	the	DET
amwa-142	113	3	time	time	NOUN
amwa-142	113	4	of	of	ADP
amwa-142	113	5	writing	writing	NOUN
amwa-142	113	6	,	,	PUNCT
amwa-142	113	7	a	a	DET
amwa-142	113	8	number	number	NOUN
amwa-142	113	9	of	of	ADP
amwa-142	113	10	large	large	ADJ
amwa-142	113	11	,	,	PUNCT
amwa-142	113	12	simple	simple	ADJ
amwa-142	113	13	trials	trial	NOUN
amwa-142	113	14	to	to	PART
amwa-142	113	15	evaluate	evaluate	VERB
amwa-142	113	16	various	various	ADJ
amwa-142	113	17	potential	potential	ADJ
amwa-142	113	18	figure	figure	NOUN
amwa-142	113	19	1	1	NUM
amwa-142	113	20	.	.	PUNCT
amwa-142	113	21	idealized	idealize	VERB
amwa-142	113	22	theoretical	theoretical	ADJ
amwa-142	113	23	framework	framework	NOUN
amwa-142	113	24	for	for	ADP
amwa-142	113	25	the	the	DET
amwa-142	113	26	generation	generation	NOUN
amwa-142	113	27	of	of	ADP
amwa-142	113	28	evidence	evidence	NOUN
amwa-142	113	29	for	for	ADP
amwa-142	113	30	efficacy	efficacy	NOUN
amwa-142	113	31	and	and	CCONJ
amwa-142	113	32	effectiveness	effectiveness	NOUN
amwa-142	113	33	.	.	PUNCT
amwa-142	114	1	hybrid	hybrid	ADJ
amwa-142	114	2	trials	trial	NOUN
amwa-142	114	3	are	be	AUX
amwa-142	114	4	studies	study	NOUN
amwa-142	114	5	that	that	PRON
amwa-142	114	6	combine	combine	VERB
amwa-142	114	7	efficacy	efficacy	NOUN
amwa-142	114	8	and	and	CCONJ
amwa-142	114	9	effectiveness	effectiveness	NOUN
amwa-142	114	10	assessments	assessment	NOUN
amwa-142	114	11	.	.	PUNCT
amwa-142	115	1	e2e	e2e	NOUN
amwa-142	115	2	,	,	PUNCT
amwa-142	115	3	efficacy	efficacy	NOUN
amwa-142	115	4	-	-	PUNCT
amwa-142	115	5	to	to	ADP
amwa-142	115	6	-	-	PUNCT
amwa-142	115	7	effectiveness	effectiveness	NOUN
amwa-142	115	8	trial	trial	NOUN
amwa-142	115	9	(	(	PUNCT
amwa-142	115	10	sequential	sequential	ADJ
amwa-142	115	11	assessment	assessment	NOUN
amwa-142	115	12	)	)	PUNCT
amwa-142	115	13	;	;	PUNCT
amwa-142	115	14	ee2	ee2	PROPN
amwa-142	115	15	,	,	PUNCT
amwa-142	115	16	efficacy	efficacy	NOUN
amwa-142	115	17	-	-	PUNCT
amwa-142	115	18	and	and	CCONJ
amwa-142	115	19	-	-	PUNCT
amwa-142	115	20	effectiveness	effectiveness	NOUN
amwa-142	115	21	-	-	PUNCT
amwa-142	115	22	too	too	ADV
amwa-142	115	23	trial	trial	NOUN
amwa-142	115	24	(	(	PUNCT
amwa-142	115	25	simultaneous	simultaneous	ADJ
amwa-142	115	26	assessment	assessment	NOUN
amwa-142	115	27	)	)	PUNCT
amwa-142	115	28	;	;	PUNCT
amwa-142	115	29	ehr	ehr	NOUN
amwa-142	115	30	,	,	PUNCT
amwa-142	115	31	electronic	electronic	ADJ
amwa-142	115	32	health	health	NOUN
amwa-142	115	33	records	record	NOUN
amwa-142	115	34	.	.	PUNCT
amwa-142	116	1	statistically	statistically	ADV
amwa-142	116	2	speaking	speak	VERB
amwa-142	116	3	continuity	continuity	NOUN
amwa-142	116	4	of	of	ADP
amwa-142	116	5	evidence	evidence	NOUN
amwa-142	116	6	classic	classic	ADJ
amwa-142	116	7	rct	rct	PROPN
amwa-142	116	8	pragmatic	pragmatic	ADJ
amwa-142	116	9	trials	trial	NOUN
amwa-142	116	10	large	large	ADJ
amwa-142	116	11	simple	simple	ADJ
amwa-142	116	12	trials	trial	NOUN
amwa-142	116	13	hybrid	hybrid	NOUN
amwa-142	116	14	trials	trial	NOUN
amwa-142	116	15	,	,	PUNCT
amwa-142	116	16	e2e	e2e	PROPN
amwa-142	116	17	,	,	PUNCT
amwa-142	116	18	ee2	ee2	PROPN
amwa-142	116	19	data	datum	NOUN
amwa-142	116	20	observed	observe	VERB
amwa-142	116	21	for	for	ADP
amwa-142	116	22	research	research	NOUN
amwa-142	116	23	purpose	purpose	NOUN
amwa-142	116	24	electronic	electronic	ADJ
amwa-142	116	25	data	datum	NOUN
amwa-142	116	26	,	,	PUNCT
amwa-142	116	27	ehr	ehr	NOUN
amwa-142	116	28	,	,	PUNCT
amwa-142	116	29	insurance	insurance	NOUN
amwa-142	116	30	claims	claim	NOUN
amwa-142	116	31	,	,	PUNCT
amwa-142	116	32	etc	etc	X
amwa-142	116	33	unstructured	unstructured	ADJ
amwa-142	116	34	data	datum	NOUN
amwa-142	116	35	efficacy	efficacy	NOUN
amwa-142	116	36	randomized	randomize	VERB
amwa-142	116	37	trials	trial	NOUN
amwa-142	116	38	observational	observational	ADJ
amwa-142	116	39	studies	study	NOUN
amwa-142	116	40	effectiveness	effectiveness	VERB
amwa-142	116	41	©	©	PROPN
amwa-142	116	42	tmschindler	tmschindler	PROPN
amwa-142	116	43	&	&	CCONJ
amwa-142	116	44	hbridge	hbridge	PROPN
amwa-142	116	45	2021	2021	NUM
amwa-142	116	46	38	38	NUM
amwa-142	116	47	amwa	amwa	PROPN
amwa-142	116	48	journal	journal	PROPN
amwa-142	116	49	/	/	SYM
amwa-142	116	50	v36	v36	PROPN
amwa-142	116	51	n1	n1	PROPN
amwa-142	116	52	/	/	SYM
amwa-142	116	53	2021	2021	NUM
amwa-142	116	54	/	/	SYM
amwa-142	116	55	amwa.org	amwa.org	X
amwa-142	116	56	treatments	treatment	NOUN
amwa-142	116	57	for	for	ADP
amwa-142	116	58	covid-19	covid-19	PROPN
amwa-142	116	59	are	be	AUX
amwa-142	116	60	ongoing	ongoing	ADJ
amwa-142	116	61	.	.	PUNCT
amwa-142	117	1	for	for	ADP
amwa-142	117	2	example	example	NOUN
amwa-142	117	3	,	,	PUNCT
amwa-142	117	4	the	the	DET
amwa-142	117	5	global	global	ADJ
amwa-142	117	6	solidarity	solidarity	NOUN
amwa-142	117	7	trial	trial	NOUN
amwa-142	117	8	,	,	PUNCT
amwa-142	117	9	initiated	initiate	VERB
amwa-142	117	10	by	by	ADP
amwa-142	117	11	the	the	DET
amwa-142	117	12	world	world	PROPN
amwa-142	117	13	health	health	PROPN
amwa-142	117	14	organization	organization	NOUN
amwa-142	117	15	,	,	PUNCT
amwa-142	117	16	had	have	AUX
amwa-142	117	17	recruited	recruit	VERB
amwa-142	117	18	over	over	ADP
amwa-142	117	19	12,000	12,000	NUM
amwa-142	117	20	patients	patient	NOUN
amwa-142	117	21	by	by	ADP
amwa-142	117	22	october	october	PROPN
amwa-142	117	23	2	2	NUM
amwa-142	117	24	,	,	PUNCT
amwa-142	117	25	2020	2020	NUM
amwa-142	117	26	,	,	PUNCT
amwa-142	117	27	with	with	ADP
amwa-142	117	28	116	116	NUM
amwa-142	117	29	countries	country	NOUN
amwa-142	117	30	having	having	AUX
amwa-142	117	31	joined	join	VERB
amwa-142	117	32	or	or	CCONJ
amwa-142	117	33	expressed	express	VERB
amwa-142	117	34	an	an	DET
amwa-142	117	35	interest	interest	NOUN
amwa-142	117	36	in	in	ADP
amwa-142	117	37	joining	join	VERB
amwa-142	117	38	the	the	DET
amwa-142	117	39	trial	trial	NOUN
amwa-142	117	40	.	.	PUNCT
amwa-142	118	1	in	in	ADP
amwa-142	118	2	the	the	DET
amwa-142	118	3	united	united	ADJ
amwa-142	118	4	kingdom	kingdom	PROPN
amwa-142	118	5	,	,	PUNCT
amwa-142	118	6	the	the	DET
amwa-142	118	7	recovery	recovery	NOUN
amwa-142	118	8	trial	trial	NOUN
amwa-142	118	9	is	be	AUX
amwa-142	118	10	being	be	AUX
amwa-142	118	11	conducted	conduct	VERB
amwa-142	118	12	at	at	ADP
amwa-142	118	13	all	all	DET
amwa-142	118	14	major	major	ADJ
amwa-142	118	15	hospitals	hospital	NOUN
amwa-142	118	16	and	and	CCONJ
amwa-142	118	17	had	have	AUX
amwa-142	118	18	enrolled	enrol	VERB
amwa-142	118	19	over	over	ADP
amwa-142	118	20	20,000	20,000	NUM
amwa-142	118	21	patients	patient	NOUN
amwa-142	118	22	by	by	ADP
amwa-142	118	23	december	december	PROPN
amwa-142	118	24	2020	2020	NUM
amwa-142	118	25	.	.	PUNCT
amwa-142	119	1	these	these	DET
amwa-142	119	2	trials	trial	NOUN
amwa-142	119	3	have	have	VERB
amwa-142	119	4	simple	simple	ADJ
amwa-142	119	5	protocols	protocol	NOUN
amwa-142	119	6	and	and	CCONJ
amwa-142	119	7	heavily	heavily	ADV
amwa-142	119	8	streamlined	streamlined	ADJ
amwa-142	119	9	procedures	procedure	NOUN
amwa-142	119	10	.	.	PUNCT
amwa-142	120	1	the	the	DET
amwa-142	120	2	aim	aim	NOUN
amwa-142	120	3	is	be	AUX
amwa-142	120	4	to	to	PART
amwa-142	120	5	maximize	maximize	VERB
amwa-142	120	6	recruitment	recruitment	NOUN
amwa-142	120	7	and	and	CCONJ
amwa-142	120	8	minimize	minimize	VERB
amwa-142	120	9	the	the	DET
amwa-142	120	10	burden	burden	NOUN
amwa-142	120	11	of	of	ADP
amwa-142	120	12	participation	participation	NOUN
amwa-142	120	13	on	on	ADP
amwa-142	120	14	health	health	NOUN
amwa-142	120	15	care	care	NOUN
amwa-142	120	16	staff	staff	NOUN
amwa-142	120	17	.	.	PUNCT
amwa-142	121	1	the	the	DET
amwa-142	121	2	recovery	recovery	NOUN
amwa-142	121	3	trial	trial	NOUN
amwa-142	121	4	,	,	PUNCT
amwa-142	121	5	for	for	ADP
amwa-142	121	6	example	example	NOUN
amwa-142	121	7	,	,	PUNCT
amwa-142	121	8	has	have	VERB
amwa-142	121	9	minimal	minimal	ADJ
amwa-142	121	10	eligibility	eligibility	NOUN
amwa-142	121	11	criteria	criterion	NOUN
amwa-142	121	12	,	,	PUNCT
amwa-142	121	13	simple	simple	ADJ
amwa-142	121	14	and	and	CCONJ
amwa-142	121	15	quick	quick	ADV
amwa-142	121	16	informed	informed	ADJ
amwa-142	121	17	consent	consent	NOUN
amwa-142	121	18	and	and	CCONJ
amwa-142	121	19	randomization	randomization	NOUN
amwa-142	121	20	processes	process	NOUN
amwa-142	121	21	,	,	PUNCT
amwa-142	121	22	and	and	CCONJ
amwa-142	121	23	minimal	minimal	ADJ
amwa-142	121	24	data	datum	NOUN
amwa-142	121	25	collection	collection	NOUN
amwa-142	121	26	requirements	requirement	NOUN
amwa-142	121	27	,	,	PUNCT
amwa-142	121	28	with	with	SCONJ
amwa-142	121	29	follow	follow	VERB
amwa-142	121	30	-	-	PUNCT
amwa-142	121	31	up	up	ADP
amwa-142	121	32	information	information	NOUN
amwa-142	121	33	to	to	PART
amwa-142	121	34	be	be	AUX
amwa-142	121	35	recorded	record	VERB
amwa-142	121	36	at	at	ADP
amwa-142	121	37	a	a	DET
amwa-142	121	38	single	single	ADJ
amwa-142	121	39	time	time	NOUN
amwa-142	121	40	point	point	NOUN
amwa-142	121	41	.	.	PUNCT
amwa-142	122	1	within	within	ADP
amwa-142	122	2	3	3	NUM
amwa-142	122	3	months	month	NOUN
amwa-142	122	4	of	of	ADP
amwa-142	122	5	trial	trial	NOUN
amwa-142	122	6	initiation	initiation	NOUN
amwa-142	122	7	,	,	PUNCT
amwa-142	122	8	results	result	NOUN
amwa-142	122	9	were	be	AUX
amwa-142	122	10	released	release	VERB
amwa-142	122	11	showing	show	VERB
amwa-142	122	12	the	the	DET
amwa-142	122	13	effectiveness	effectiveness	NOUN
amwa-142	122	14	of	of	ADP
amwa-142	122	15	dexamethasone	dexamethasone	NOUN
amwa-142	122	16	for	for	ADP
amwa-142	122	17	reducing	reduce	VERB
amwa-142	122	18	mortality	mortality	NOUN
amwa-142	122	19	in	in	ADP
amwa-142	122	20	patients	patient	NOUN
amwa-142	122	21	on	on	ADP
amwa-142	122	22	mechanical	mechanical	ADJ
amwa-142	122	23	ventilation	ventilation	NOUN
amwa-142	122	24	or	or	CCONJ
amwa-142	122	25	supplemental	supplemental	ADJ
amwa-142	122	26	oxygen	oxygen	NOUN
amwa-142	122	27	.	.	PUNCT
amwa-142	123	1	the	the	DET
amwa-142	123	2	trial	trial	NOUN
amwa-142	123	3	has	have	AUX
amwa-142	123	4	also	also	ADV
amwa-142	123	5	shown	show	VERB
amwa-142	123	6	hydroxychloroquine	hydroxychloroquine	PROPN
amwa-142	123	7	,	,	PUNCT
amwa-142	123	8	lopinavir	lopinavir	NOUN
amwa-142	123	9	and	and	CCONJ
amwa-142	123	10	ritonavir	ritonavir	PROPN
amwa-142	123	11	,	,	PUNCT
amwa-142	123	12	and	and	CCONJ
amwa-142	123	13	azithromycin	azithromycin	VERB
amwa-142	123	14	to	to	PART
amwa-142	123	15	be	be	AUX
amwa-142	123	16	ineffective	ineffective	ADJ
amwa-142	123	17	at	at	ADP
amwa-142	123	18	reducing	reduce	VERB
amwa-142	123	19	mortality	mortality	NOUN
amwa-142	123	20	from	from	ADP
amwa-142	123	21	covid-19	covid-19	PROPN
amwa-142	123	22	.	.	PUNCT
amwa-142	124	1	these	these	DET
amwa-142	124	2	examples	example	NOUN
amwa-142	124	3	show	show	VERB
amwa-142	124	4	the	the	DET
amwa-142	124	5	potential	potential	NOUN
amwa-142	124	6	of	of	ADP
amwa-142	124	7	combining	combine	VERB
amwa-142	124	8	rcts	rct	NOUN
amwa-142	124	9	with	with	ADP
amwa-142	124	10	rwd	rwd	NOUN
amwa-142	124	11	to	to	PART
amwa-142	124	12	produce	produce	VERB
amwa-142	124	13	robust	robust	ADJ
amwa-142	124	14	evidence	evidence	NOUN
amwa-142	124	15	of	of	ADP
amwa-142	124	16	effectiveness	effectiveness	NOUN
amwa-142	124	17	that	that	PRON
amwa-142	124	18	can	can	AUX
amwa-142	124	19	inform	inform	VERB
amwa-142	124	20	decision	decision	NOUN
amwa-142	124	21	-	-	PUNCT
amwa-142	124	22	making	making	NOUN
amwa-142	124	23	about	about	ADP
amwa-142	124	24	treatments	treatment	NOUN
amwa-142	124	25	.	.	PUNCT
amwa-142	125	1	they	they	PRON
amwa-142	125	2	also	also	ADV
amwa-142	125	3	indicate	indicate	VERB
amwa-142	125	4	that	that	SCONJ
amwa-142	125	5	the	the	DET
amwa-142	125	6	use	use	NOUN
amwa-142	125	7	of	of	ADP
amwa-142	125	8	rwd	rwd	NOUN
amwa-142	125	9	,	,	PUNCT
amwa-142	125	10	while	while	SCONJ
amwa-142	125	11	informative	informative	ADJ
amwa-142	125	12	as	as	ADP
amwa-142	125	13	a	a	DET
amwa-142	125	14	supplement	supplement	NOUN
amwa-142	125	15	to	to	ADP
amwa-142	125	16	rcts	rct	NOUN
amwa-142	125	17	in	in	ADP
amwa-142	125	18	certain	certain	ADJ
amwa-142	125	19	contexts	context	NOUN
amwa-142	125	20	,	,	PUNCT
amwa-142	125	21	is	be	AUX
amwa-142	125	22	unlikely	unlikely	ADJ
amwa-142	125	23	to	to	PART
amwa-142	125	24	replace	replace	VERB
amwa-142	125	25	traditional	traditional	ADJ
amwa-142	125	26	rcts	rct	NOUN
amwa-142	125	27	.	.	PUNCT
amwa-142	126	1	until	until	SCONJ
amwa-142	126	2	a	a	DET
amwa-142	126	3	treatment	treatment	NOUN
amwa-142	126	4	is	be	AUX
amwa-142	126	5	widely	widely	ADV
amwa-142	126	6	used	use	VERB
amwa-142	126	7	in	in	ADP
amwa-142	126	8	clinical	clinical	ADJ
amwa-142	126	9	practice	practice	NOUN
amwa-142	126	10	,	,	PUNCT
amwa-142	126	11	there	there	PRON
amwa-142	126	12	are	be	VERB
amwa-142	126	13	no	no	DET
amwa-142	126	14	rwd	rwd	NOUN
amwa-142	126	15	relating	relate	VERB
amwa-142	126	16	to	to	ADP
amwa-142	126	17	its	its	PRON
amwa-142	126	18	use	use	NOUN
amwa-142	126	19	.	.	PUNCT
amwa-142	127	1	consequently	consequently	ADV
amwa-142	127	2	,	,	PUNCT
amwa-142	127	3	data	datum	NOUN
amwa-142	127	4	to	to	PART
amwa-142	127	5	support	support	VERB
amwa-142	127	6	firsttime	firsttime	NOUN
amwa-142	127	7	marketing	marketing	NOUN
amwa-142	127	8	approvals	approval	NOUN
amwa-142	127	9	for	for	ADP
amwa-142	127	10	new	new	ADJ
amwa-142	127	11	drugs	drug	NOUN
amwa-142	127	12	have	have	VERB
amwa-142	127	13	to	to	PART
amwa-142	127	14	come	come	VERB
amwa-142	127	15	from	from	ADP
amwa-142	127	16	rcts	rct	NOUN
amwa-142	127	17	.	.	PUNCT
amwa-142	128	1	the	the	DET
amwa-142	128	2	context	context	NOUN
amwa-142	128	3	of	of	ADP
amwa-142	128	4	a	a	DET
amwa-142	128	5	clinical	clinical	ADJ
amwa-142	128	6	trial	trial	NOUN
amwa-142	128	7	also	also	ADV
amwa-142	128	8	allows	allow	VERB
amwa-142	128	9	close	close	ADJ
amwa-142	128	10	monitoring	monitoring	NOUN
amwa-142	128	11	of	of	ADP
amwa-142	128	12	patients	patient	NOUN
amwa-142	128	13	,	,	PUNCT
amwa-142	128	14	which	which	PRON
amwa-142	128	15	is	be	AUX
amwa-142	128	16	essential	essential	ADJ
amwa-142	128	17	for	for	ADP
amwa-142	128	18	their	their	PRON
amwa-142	128	19	safety	safety	NOUN
amwa-142	128	20	with	with	ADP
amwa-142	128	21	drugs	drug	NOUN
amwa-142	128	22	that	that	PRON
amwa-142	128	23	have	have	AUX
amwa-142	128	24	not	not	PART
amwa-142	128	25	yet	yet	ADV
amwa-142	128	26	received	receive	VERB
amwa-142	128	27	marketing	marketing	NOUN
amwa-142	128	28	authorization	authorization	NOUN
amwa-142	128	29	.	.	PUNCT
amwa-142	129	1	as	as	ADP
amwa-142	129	2	the	the	DET
amwa-142	129	3	examples	example	NOUN
amwa-142	129	4	given	give	VERB
amwa-142	129	5	show	show	NOUN
amwa-142	129	6	,	,	PUNCT
amwa-142	129	7	the	the	DET
amwa-142	129	8	situation	situation	NOUN
amwa-142	129	9	is	be	AUX
amwa-142	129	10	very	very	ADV
amwa-142	129	11	different	different	ADJ
amwa-142	129	12	when	when	SCONJ
amwa-142	129	13	a	a	DET
amwa-142	129	14	new	new	ADJ
amwa-142	129	15	drug	drug	NOUN
amwa-142	129	16	is	be	AUX
amwa-142	129	17	to	to	PART
amwa-142	129	18	be	be	AUX
amwa-142	129	19	compared	compare	VERB
amwa-142	129	20	with	with	ADP
amwa-142	129	21	a	a	DET
amwa-142	129	22	widely	widely	ADV
amwa-142	129	23	used	use	VERB
amwa-142	129	24	drug	drug	NOUN
amwa-142	129	25	or	or	CCONJ
amwa-142	129	26	when	when	SCONJ
amwa-142	129	27	well	well	ADV
amwa-142	129	28	-	-	PUNCT
amwa-142	129	29	established	establish	VERB
amwa-142	129	30	drugs	drug	NOUN
amwa-142	129	31	are	be	AUX
amwa-142	129	32	to	to	PART
amwa-142	129	33	be	be	AUX
amwa-142	129	34	evaluated	evaluate	VERB
amwa-142	129	35	as	as	ADP
amwa-142	129	36	potential	potential	ADJ
amwa-142	129	37	treatments	treatment	NOUN
amwa-142	129	38	for	for	ADP
amwa-142	129	39	a	a	DET
amwa-142	129	40	new	new	ADJ
amwa-142	129	41	disease	disease	NOUN
amwa-142	129	42	.	.	PUNCT
amwa-142	130	1	author	author	NOUN
amwa-142	130	2	declaration	declaration	NOUN
amwa-142	130	3	and	and	CCONJ
amwa-142	130	4	disclosures	disclosure	NOUN
amwa-142	130	5	:	:	PUNCT
amwa-142	130	6	the	the	DET
amwa-142	130	7	authors	author	NOUN
amwa-142	130	8	note	note	VERB
amwa-142	130	9	no	no	DET
amwa-142	130	10	commercial	commercial	ADJ
amwa-142	130	11	associations	association	NOUN
amwa-142	130	12	that	that	PRON
amwa-142	130	13	may	may	AUX
amwa-142	130	14	pose	pose	VERB
amwa-142	130	15	a	a	DET
amwa-142	130	16	conflict	conflict	NOUN
amwa-142	130	17	of	of	ADP
amwa-142	130	18	interest	interest	NOUN
amwa-142	130	19	in	in	ADP
amwa-142	130	20	relation	relation	NOUN
amwa-142	130	21	to	to	ADP
amwa-142	130	22	this	this	DET
amwa-142	130	23	article	article	NOUN
amwa-142	130	24	.	.	PUNCT
amwa-142	131	1	author	author	NOUN
amwa-142	131	2	contacts	contact	NOUN
amwa-142	131	3	:	:	PUNCT
amwa-142	131	4	thomas.schindler@boehringer-ingelheim.com	thomas.schindler@boehringer-ingelheim.com	X
amwa-142	131	5	;	;	PUNCT
amwa-142	131	6	helen	helen	PROPN
amwa-142	131	7	.	.	PUNCT
amwa-142	132	1	bridge@astrazeneca.com	bridge@astrazeneca.com	X
amwa-142	133	1	resources	resource	NOUN
amwa-142	133	2	baumfeld	baumfeld	VERB
amwa-142	133	3	andre	andre	PROPN
amwa-142	133	4	e	e	PROPN
amwa-142	133	5	,	,	PUNCT
amwa-142	133	6	reynolds	reynolds	PROPN
amwa-142	133	7	r	r	PROPN
amwa-142	133	8	,	,	PUNCT
amwa-142	133	9	caubel	caubel	NOUN
amwa-142	133	10	p	p	NOUN
amwa-142	133	11	,	,	PUNCT
amwa-142	133	12	azoulay	azoulay	VERB
amwa-142	133	13	l	l	NOUN
amwa-142	133	14	,	,	PUNCT
amwa-142	133	15	dreyer	dreyer	PROPN
amwa-142	133	16	na	na	PROPN
amwa-142	133	17	.	.	PROPN
amwa-142	133	18	trial	trial	NOUN
amwa-142	133	19	designs	design	NOUN
amwa-142	133	20	using	use	VERB
amwa-142	133	21	real	real	ADJ
amwa-142	133	22	-	-	PUNCT
amwa-142	133	23	world	world	NOUN
amwa-142	133	24	data	datum	NOUN
amwa-142	133	25	:	:	PUNCT
amwa-142	133	26	the	the	DET
amwa-142	133	27	changing	change	VERB
amwa-142	133	28	landscape	landscape	NOUN
amwa-142	133	29	of	of	ADP
amwa-142	133	30	the	the	DET
amwa-142	133	31	regulatory	regulatory	ADJ
amwa-142	133	32	approval	approval	NOUN
amwa-142	133	33	process	process	NOUN
amwa-142	133	34	.	.	PUNCT
amwa-142	134	1	pharmacoepidemiol	pharmacoepidemiol	PROPN
amwa-142	134	2	drug	drug	PROPN
amwa-142	134	3	saf	saf	PROPN
amwa-142	134	4	.	.	PUNCT
amwa-142	135	1	2020;29(10):1201	2020;29(10):1201	X
amwa-142	135	2	-	-	SYM
amwa-142	135	3	1212	1212	NUM
amwa-142	135	4	.	.	PUNCT
amwa-142	136	1	beaulieu	beaulieu	NOUN
amwa-142	136	2	-	-	PUNCT
amwa-142	136	3	jones	jones	PROPN
amwa-142	136	4	bk	bk	PROPN
amwa-142	136	5	,	,	PUNCT
amwa-142	136	6	finlayson	finlayson	PROPN
amwa-142	136	7	sg	sg	PROPN
amwa-142	136	8	,	,	PUNCT
amwa-142	136	9	yuan	yuan	PROPN
amwa-142	136	10	w	w	PROPN
amwa-142	136	11	,	,	PUNCT
amwa-142	136	12	et	et	PROPN
amwa-142	136	13	al	al	PROPN
amwa-142	136	14	.	.	PUNCT
amwa-142	136	15	examining	examine	VERB
amwa-142	136	16	the	the	DET
amwa-142	136	17	use	use	NOUN
amwa-142	136	18	of	of	ADP
amwa-142	136	19	real	real	ADJ
amwa-142	136	20	-	-	PUNCT
amwa-142	136	21	world	world	NOUN
amwa-142	136	22	evidence	evidence	NOUN
amwa-142	136	23	in	in	ADP
amwa-142	136	24	the	the	DET
amwa-142	136	25	regulatory	regulatory	ADJ
amwa-142	136	26	process	process	NOUN
amwa-142	136	27	.	.	PUNCT
amwa-142	137	1	clin	clin	PROPN
amwa-142	137	2	pharmacol	pharmacol	PROPN
amwa-142	137	3	ther	ther	ADV
amwa-142	137	4	.	.	PUNCT
amwa-142	138	1	2020;107(4):843	2020;107(4):843	NUM
amwa-142	138	2	-	-	SYM
amwa-142	138	3	852	852	NUM
amwa-142	138	4	.	.	PUNCT
amwa-142	139	1	collins	collins	PROPN
amwa-142	139	2	r	r	PROPN
amwa-142	139	3	,	,	PUNCT
amwa-142	139	4	bowman	bowman	PROPN
amwa-142	139	5	l	l	PROPN
amwa-142	139	6	,	,	PUNCT
amwa-142	139	7	landray	landray	PROPN
amwa-142	139	8	m	m	PROPN
amwa-142	139	9	,	,	PUNCT
amwa-142	139	10	peto	peto	PROPN
amwa-142	139	11	r.	r.	NOUN
amwa-142	139	12	the	the	DET
amwa-142	139	13	magic	magic	NOUN
amwa-142	139	14	of	of	ADP
amwa-142	139	15	randomization	randomization	NOUN
amwa-142	139	16	versus	versus	ADP
amwa-142	139	17	the	the	DET
amwa-142	139	18	myth	myth	NOUN
amwa-142	139	19	of	of	ADP
amwa-142	139	20	real	real	ADJ
amwa-142	139	21	-	-	PUNCT
amwa-142	139	22	world	world	NOUN
amwa-142	139	23	evidence	evidence	NOUN
amwa-142	139	24	.	.	PUNCT
amwa-142	140	1	n	n	X
amwa-142	140	2	engl	engl	PROPN
amwa-142	140	3	j	j	PROPN
amwa-142	140	4	med	med	PROPN
amwa-142	140	5	.	.	PUNCT
amwa-142	141	1	2020;382(7):674	2020;382(7):674	NUM
amwa-142	141	2	-	-	SYM
amwa-142	141	3	678	678	NUM
amwa-142	141	4	.	.	PUNCT
amwa-142	141	5	epstein	epstein	PROPN
amwa-142	141	6	d	d	PROPN
amwa-142	141	7	,	,	PUNCT
amwa-142	141	8	propublica	propublica	PROPN
amwa-142	141	9	.	.	PUNCT
amwa-142	142	1	when	when	SCONJ
amwa-142	142	2	evidence	evidence	NOUN
amwa-142	142	3	says	say	VERB
amwa-142	142	4	no	no	INTJ
amwa-142	142	5	,	,	PUNCT
amwa-142	142	6	but	but	CCONJ
amwa-142	142	7	doctors	doctor	NOUN
amwa-142	142	8	say	say	VERB
amwa-142	142	9	yes	yes	INTJ
amwa-142	142	10	.	.	PUNCT
amwa-142	143	1	the	the	DET
amwa-142	143	2	atlantic	atlantic	PROPN
amwa-142	143	3	website	website	NOUN
amwa-142	143	4	.	.	PUNCT
amwa-142	144	1	published	publish	VERB
amwa-142	144	2	february	february	PROPN
amwa-142	144	3	22	22	NUM
amwa-142	144	4	,	,	PUNCT
amwa-142	144	5	2017	2017	NUM
amwa-142	144	6	.	.	PUNCT
amwa-142	145	1	accessed	access	VERB
amwa-142	145	2	january	january	PROPN
amwa-142	145	3	8	8	NUM
amwa-142	145	4	,	,	PUNCT
amwa-142	145	5	2021	2021	NUM
amwa-142	145	6	.	.	PUNCT
amwa-142	146	1	https://www.theatlantic.com/health/archive/2017/02/when-evidence-saysno-but-doctors-say-yes/517368/	https://www.theatlantic.com/health/archive/2017/02/when-evidence-saysno-but-doctors-say-yes/517368/	PROPN
amwa-142	146	2	ford	ford	PROPN
amwa-142	146	3	i	i	PROPN
amwa-142	146	4	,	,	PUNCT
amwa-142	146	5	norrie	norrie	PROPN
amwa-142	146	6	j.	j.	PROPN
amwa-142	146	7	pragmatic	pragmatic	PROPN
amwa-142	146	8	trials	trial	NOUN
amwa-142	146	9	.	.	PUNCT
amwa-142	147	1	n	n	PROPN
amwa-142	147	2	engl	engl	PROPN
amwa-142	147	3	j	j	PROPN
amwa-142	147	4	med	med	PROPN
amwa-142	147	5	.	.	PUNCT
amwa-142	148	1	2016;375(5):454	2016;375(5):454	X
amwa-142	148	2	-	-	SYM
amwa-142	148	3	463	463	NUM
amwa-142	148	4	.	.	PUNCT
amwa-142	149	1	franklin	franklin	PROPN
amwa-142	149	2	jm	jm	PROPN
amwa-142	149	3	,	,	PUNCT
amwa-142	149	4	schneeweiss	schneeweiss	PROPN
amwa-142	149	5	s.	s.	PROPN
amwa-142	149	6	when	when	SCONJ
amwa-142	149	7	and	and	CCONJ
amwa-142	149	8	how	how	SCONJ
amwa-142	149	9	can	can	AUX
amwa-142	149	10	real	real	ADJ
amwa-142	149	11	world	world	NOUN
amwa-142	149	12	data	data	PROPN
amwa-142	149	13	analyses	analyse	VERB
amwa-142	149	14	substitute	substitute	NOUN
amwa-142	149	15	for	for	ADP
amwa-142	149	16	randomized	randomized	ADJ
amwa-142	149	17	controlled	control	VERB
amwa-142	149	18	trials	trial	NOUN
amwa-142	149	19	?	?	PUNCT
amwa-142	150	1	clin	clin	PROPN
amwa-142	150	2	pharmacol	pharmacol	PROPN
amwa-142	150	3	ther	ther	ADV
amwa-142	150	4	.	.	PUNCT
amwa-142	151	1	2017;102(6):924	2017;102(6):924	NOUN
amwa-142	151	2	-	-	SYM
amwa-142	151	3	933	933	NUM
amwa-142	151	4	.	.	PUNCT
amwa-142	152	1	najafzadeh	najafzadeh	PROPN
amwa-142	152	2	m	m	PROPN
amwa-142	152	3	,	,	PUNCT
amwa-142	152	4	gagne	gagne	PROPN
amwa-142	152	5	jj	jj	PROPN
amwa-142	152	6	,	,	PUNCT
amwa-142	152	7	schneeweiss	schneeweiss	PROPN
amwa-142	152	8	s.	s.	PROPN
amwa-142	152	9	synergies	synergies	PROPN
amwa-142	152	10	from	from	ADP
amwa-142	152	11	integrating	integrate	VERB
amwa-142	152	12	randomized	randomize	VERB
amwa-142	152	13	controlled	control	VERB
amwa-142	152	14	trials	trial	NOUN
amwa-142	152	15	and	and	CCONJ
amwa-142	152	16	real	real	ADJ
amwa-142	152	17	-	-	PUNCT
amwa-142	152	18	world	world	NOUN
amwa-142	152	19	data	datum	NOUN
amwa-142	152	20	analyses	analysis	NOUN
amwa-142	152	21	.	.	PUNCT
amwa-142	153	1	clin	clin	PROPN
amwa-142	153	2	pharmacol	pharmacol	PROPN
amwa-142	153	3	ther	ther	ADV
amwa-142	153	4	.	.	PUNCT
amwa-142	154	1	2017;102(6):914	2017;102(6):914	NUM
amwa-142	154	2	-	-	SYM
amwa-142	154	3	916	916	NUM
amwa-142	154	4	.	.	PUNCT
amwa-142	155	1	randomised	randomise	VERB
amwa-142	155	2	evaluation	evaluation	NOUN
amwa-142	155	3	of	of	ADP
amwa-142	155	4	covid-19	covid-19	PROPN
amwa-142	155	5	therapy	therapy	NOUN
amwa-142	155	6	(	(	PUNCT
amwa-142	155	7	recovery	recovery	NOUN
amwa-142	155	8	)	)	PUNCT
amwa-142	155	9	clinical	clinical	ADJ
amwa-142	155	10	study	study	NOUN
amwa-142	155	11	protocol	protocol	NOUN
amwa-142	155	12	,	,	PUNCT
amwa-142	155	13	v12.1	v12.1	NOUN
amwa-142	155	14	.	.	PUNCT
amwa-142	155	15	recovery	recovery	NOUN
amwa-142	155	16	trial	trial	NOUN
amwa-142	155	17	website	website	NOUN
amwa-142	155	18	.	.	PUNCT
amwa-142	156	1	published	publish	VERB
amwa-142	156	2	december	december	PROPN
amwa-142	156	3	16	16	NUM
amwa-142	156	4	,	,	PUNCT
amwa-142	156	5	2020	2020	NUM
amwa-142	156	6	.	.	PUNCT
amwa-142	157	1	accessed	access	VERB
amwa-142	157	2	january	january	PROPN
amwa-142	157	3	8	8	NUM
amwa-142	157	4	,	,	PUNCT
amwa-142	157	5	2021	2021	NUM
amwa-142	157	6	.	.	PUNCT
amwa-142	158	1	https://www.recoverytrial.net/files/recoveryprotocol-v12-1-2020-12-16.pdf	https://www.recoverytrial.net/files/recoveryprotocol-v12-1-2020-12-16.pdf	PROPN
amwa-142	158	2	reynolds	reynolds	PROPN
amwa-142	158	3	mw	mw	PROPN
amwa-142	158	4	,	,	PUNCT
amwa-142	158	5	bourke	bourke	PROPN
amwa-142	158	6	a	a	PROPN
amwa-142	158	7	,	,	PUNCT
amwa-142	158	8	dreyer	dreyer	PROPN
amwa-142	158	9	na	na	PROPN
amwa-142	158	10	.	.	PROPN
amwa-142	158	11	considerations	consideration	NOUN
amwa-142	158	12	when	when	SCONJ
amwa-142	158	13	evaluating	evaluate	VERB
amwa-142	158	14	realworld	realworld	PROPN
amwa-142	158	15	data	datum	NOUN
amwa-142	158	16	quality	quality	NOUN
amwa-142	158	17	in	in	ADP
amwa-142	158	18	the	the	DET
amwa-142	158	19	context	context	NOUN
amwa-142	158	20	of	of	ADP
amwa-142	158	21	fitness	fitness	NOUN
amwa-142	158	22	for	for	ADP
amwa-142	158	23	purpose	purpose	NOUN
amwa-142	158	24	.	.	PUNCT
amwa-142	159	1	pharmacoepidemiol	pharmacoepidemiol	PROPN
amwa-142	159	2	drug	drug	PROPN
amwa-142	159	3	saf	saf	PROPN
amwa-142	159	4	.	.	PUNCT
amwa-142	160	1	2020;29(10):1316	2020;29(10):1316	NUM
amwa-142	160	2	-	-	SYM
amwa-142	160	3	1318	1318	NUM
amwa-142	160	4	.	.	PUNCT
amwa-142	161	1	saesen	saesen	NOUN
amwa-142	161	2	r	r	NOUN
amwa-142	161	3	,	,	PUNCT
amwa-142	161	4	huys	huys	PROPN
amwa-142	161	5	i.	i.	PROPN
amwa-142	161	6	covid-19	covid-19	PROPN
amwa-142	161	7	clinical	clinical	ADJ
amwa-142	161	8	trials	trial	NOUN
amwa-142	161	9	:	:	PUNCT
amwa-142	161	10	see	see	VERB
amwa-142	161	11	it	it	PRON
amwa-142	161	12	big	big	ADJ
amwa-142	161	13	and	and	CCONJ
amwa-142	161	14	keep	keep	VERB
amwa-142	161	15	it	it	PRON
amwa-142	161	16	simple	simple	ADJ
amwa-142	161	17	.	.	PUNCT
amwa-142	162	1	bmj	bmj	PROPN
amwa-142	162	2	evid	evid	PROPN
amwa-142	162	3	based	base	VERB
amwa-142	162	4	med	med	PROPN
amwa-142	162	5	.	.	PUNCT
amwa-142	163	1	published	publish	VERB
amwa-142	163	2	online	online	ADJ
amwa-142	163	3	july	july	PROPN
amwa-142	163	4	8	8	NUM
amwa-142	163	5	,	,	PUNCT
amwa-142	163	6	2020	2020	NUM
amwa-142	163	7	.	.	PUNCT
amwa-142	164	1	doi:10.1136	doi:10.1136	NOUN
amwa-142	164	2	/	/	SYM
amwa-142	164	3	bmjebm-2020111447	bmjebm-2020111447	NOUN
amwa-142	164	4	schindler	schindler	NOUN
amwa-142	164	5	tm	tm	PROPN
amwa-142	164	6	,	,	PUNCT
amwa-142	164	7	bridge	bridge	PROPN
amwa-142	164	8	h.	h.	PROPN
amwa-142	165	1	the	the	DET
amwa-142	165	2	evaluation	evaluation	NOUN
amwa-142	165	3	of	of	ADP
amwa-142	165	4	efficacy	efficacy	NOUN
amwa-142	165	5	,	,	PUNCT
amwa-142	165	6	or	or	CCONJ
amwa-142	165	7	how	how	SCONJ
amwa-142	165	8	do	do	AUX
amwa-142	165	9	we	we	PRON
amwa-142	165	10	know	know	VERB
amwa-142	165	11	whether	whether	SCONJ
amwa-142	165	12	a	a	DET
amwa-142	165	13	treatment	treatment	NOUN
amwa-142	165	14	works	work	VERB
amwa-142	165	15	?	?	PUNCT
amwa-142	166	1	part	part	NOUN
amwa-142	166	2	1	1	NUM
amwa-142	166	3	.	.	PUNCT
amwa-142	166	4	amwa	amwa	PROPN
amwa-142	166	5	j.	j.	PROPN
amwa-142	167	1	2020;35(2):82	2020;35(2):82	PROPN
amwa-142	167	2	-	-	SYM
amwa-142	167	3	86	86	NUM
amwa-142	167	4	.	.	PUNCT
amwa-142	168	1	scott	scott	PROPN
amwa-142	168	2	ia	ia	PROPN
amwa-142	168	3	,	,	PUNCT
amwa-142	168	4	attia	attia	PROPN
amwa-142	168	5	j.	j.	PROPN
amwa-142	168	6	cautionary	cautionary	PROPN
amwa-142	168	7	tales	tale	NOUN
amwa-142	168	8	in	in	ADP
amwa-142	168	9	the	the	DET
amwa-142	168	10	interpretation	interpretation	NOUN
amwa-142	168	11	of	of	ADP
amwa-142	168	12	observational	observational	ADJ
amwa-142	168	13	studies	study	NOUN
amwa-142	168	14	of	of	ADP
amwa-142	168	15	effects	effect	NOUN
amwa-142	168	16	of	of	ADP
amwa-142	168	17	clinical	clinical	ADJ
amwa-142	168	18	interventions	intervention	NOUN
amwa-142	168	19	.	.	PUNCT
amwa-142	169	1	intern	intern	NOUN
amwa-142	169	2	med	med	PROPN
amwa-142	169	3	j.	j.	PROPN
amwa-142	169	4	2017;47(2):144	2017;47(2):144	PROPN
amwa-142	169	5	-	-	SYM
amwa-142	169	6	157	157	NUM
amwa-142	169	7	.	.	PUNCT
amwa-142	170	1	selker	selker	PROPN
amwa-142	170	2	hp	hp	PROPN
amwa-142	170	3	,	,	PUNCT
amwa-142	170	4	eichler	eichler	NOUN
amwa-142	170	5	h	h	NOUN
amwa-142	170	6	-	-	PUNCT
amwa-142	170	7	g	g	NOUN
amwa-142	170	8	,	,	PUNCT
amwa-142	170	9	stockbridge	stockbridge	PROPN
amwa-142	170	10	nl	nl	PROPN
amwa-142	170	11	,	,	PUNCT
amwa-142	170	12	et	et	PROPN
amwa-142	170	13	al	al	PROPN
amwa-142	170	14	.	.	PROPN
amwa-142	170	15	efficacy	efficacy	NOUN
amwa-142	170	16	and	and	CCONJ
amwa-142	170	17	effectiveness	effectiveness	NOUN
amwa-142	170	18	too	too	ADP
amwa-142	170	19	trials	trial	NOUN
amwa-142	170	20	:	:	PUNCT
amwa-142	170	21	clinical	clinical	ADJ
amwa-142	170	22	trial	trial	NOUN
amwa-142	170	23	designs	design	NOUN
amwa-142	170	24	to	to	PART
amwa-142	170	25	generate	generate	VERB
amwa-142	170	26	evidence	evidence	NOUN
amwa-142	170	27	on	on	ADP
amwa-142	170	28	efficacy	efficacy	NOUN
amwa-142	170	29	and	and	CCONJ
amwa-142	170	30	on	on	ADP
amwa-142	170	31	effectiveness	effectiveness	NOUN
amwa-142	170	32	in	in	ADP
amwa-142	170	33	wide	wide	ADJ
amwa-142	170	34	practice	practice	NOUN
amwa-142	170	35	.	.	PUNCT
amwa-142	171	1	clin	clin	PROPN
amwa-142	171	2	pharmacol	pharmacol	PROPN
amwa-142	171	3	ther	ther	ADV
amwa-142	171	4	.	.	PUNCT
amwa-142	172	1	2019;105(4):857	2019;105(4):857	NUM
amwa-142	172	2	-	-	SYM
amwa-142	172	3	866	866	NUM
amwa-142	172	4	.	.	PUNCT
amwa-142	173	1	sherman	sherman	PROPN
amwa-142	173	2	re	re	PROPN
amwa-142	173	3	,	,	PUNCT
amwa-142	173	4	anderson	anderson	PROPN
amwa-142	173	5	sa	sa	PROPN
amwa-142	173	6	,	,	PUNCT
amwa-142	173	7	dal	dal	PROPN
amwa-142	173	8	pan	pan	PROPN
amwa-142	173	9	gj	gj	PROPN
amwa-142	173	10	,	,	PUNCT
amwa-142	173	11	et	et	PROPN
amwa-142	173	12	al	al	PROPN
amwa-142	173	13	.	.	PUNCT
amwa-142	174	1	real	real	ADJ
amwa-142	174	2	-	-	PUNCT
amwa-142	174	3	world	world	NOUN
amwa-142	174	4	evidence	evidence	NOUN
amwa-142	174	5	–	–	PUNCT
amwa-142	174	6	what	what	PRON
amwa-142	174	7	is	be	AUX
amwa-142	174	8	it	it	PRON
amwa-142	174	9	and	and	CCONJ
amwa-142	174	10	what	what	PRON
amwa-142	174	11	can	can	AUX
amwa-142	174	12	it	it	PRON
amwa-142	174	13	tell	tell	VERB
amwa-142	174	14	us	we	PRON
amwa-142	174	15	?	?	PUNCT
amwa-142	175	1	new	new	ADJ
amwa-142	175	2	engl	engl	PROPN
amwa-142	175	3	j	j	PROPN
amwa-142	175	4	med	med	PROPN
amwa-142	175	5	.	.	PUNCT
amwa-142	176	1	2016;375(23):2293	2016;375(23):2293	NUM
amwa-142	176	2	-	-	SYM
amwa-142	176	3	2297	2297	NUM
amwa-142	176	4	.	.	PUNCT
amwa-142	177	1	world	world	PROPN
amwa-142	177	2	health	health	PROPN
amwa-142	177	3	organization	organization	NOUN
amwa-142	177	4	.	.	PUNCT
amwa-142	178	1	“	"	PUNCT
amwa-142	178	2	solidarity	solidarity	NOUN
amwa-142	178	3	”	"	PUNCT
amwa-142	178	4	clinical	clinical	ADJ
amwa-142	178	5	trial	trial	NOUN
amwa-142	178	6	for	for	ADP
amwa-142	178	7	covid-19	covid-19	PROPN
amwa-142	178	8	treatments	treatment	NOUN
amwa-142	178	9	.	.	PUNCT
amwa-142	179	1	published	publish	VERB
amwa-142	179	2	2020	2020	NUM
amwa-142	179	3	.	.	PUNCT
amwa-142	180	1	accessed	access	VERB
amwa-142	180	2	january	january	PROPN
amwa-142	180	3	8	8	NUM
amwa-142	180	4	,	,	PUNCT
amwa-142	180	5	2021	2021	NUM
amwa-142	180	6	.	.	PUNCT
amwa-142	181	1	https://www.who.int/	https://www.who.int/	NOUN
amwa-142	181	2	emergencies	emergency	NOUN
amwa-142	181	3	/	/	SYM
amwa-142	181	4	diseases	disease	NOUN
amwa-142	181	5	/	/	SYM
amwa-142	181	6	novel	novel	NOUN
amwa-142	181	7	-	-	PUNCT
amwa-142	181	8	coronavirus-2019	coronavirus-2019	VERB
amwa-142	181	9	/	/	SYM
amwa-142	181	10	global	global	ADJ
amwa-142	181	11	-	-	PUNCT
amwa-142	181	12	research	research	NOUN
amwa-142	181	13	-	-	PUNCT
amwa-142	181	14	on	on	ADP
amwa-142	181	15	-	-	PUNCT
amwa-142	181	16	novelcoronavirus-2019	novelcoronavirus-2019	ADJ
amwa-142	181	17	-	-	PUNCT
amwa-142	181	18	ncov	ncov	NOUN
amwa-142	181	19	/	/	SYM
amwa-142	181	20	solidarity	solidarity	NOUN
amwa-142	181	21	-	-	PUNCT
amwa-142	181	22	clinical	clinical	ADJ
amwa-142	181	23	-	-	PUNCT
amwa-142	181	24	trial	trial	NOUN
amwa-142	181	25	-	-	PUNCT
amwa-142	181	26	for	for	ADP
amwa-142	181	27	-	-	PUNCT
amwa-142	181	28	covid-19	covid-19	PROPN
amwa-142	181	29	-	-	PUNCT
amwa-142	181	30	treatments	treatment	NOUN
amwa-142	181	31	us	we	PRON
amwa-142	181	32	food	food	NOUN
amwa-142	181	33	and	and	CCONJ
amwa-142	181	34	drug	drug	PROPN
amwa-142	181	35	administration	administration	NOUN
amwa-142	181	36	.	.	PUNCT
amwa-142	182	1	framework	framework	PROPN
amwa-142	182	2	for	for	ADP
amwa-142	182	3	fda	fda	PROPN
amwa-142	182	4	’s	’s	PART
amwa-142	182	5	real	real	ADJ
amwa-142	182	6	-	-	PUNCT
amwa-142	182	7	world	world	NOUN
amwa-142	182	8	evidence	evidence	NOUN
amwa-142	182	9	program	program	NOUN
amwa-142	182	10	.	.	PUNCT
amwa-142	183	1	published	publish	VERB
amwa-142	183	2	december	december	PROPN
amwa-142	183	3	2018	2018	NUM
amwa-142	183	4	.	.	PUNCT
amwa-142	184	1	accessed	access	VERB
amwa-142	184	2	january	january	PROPN
amwa-142	184	3	8	8	NUM
amwa-142	184	4	,	,	PUNCT
amwa-142	184	5	2021	2021	NUM
amwa-142	184	6	.	.	PUNCT
amwa-142	185	1	https://www	https://www	PROPN
amwa-142	185	2	.	.	PROPN
amwa-142	185	3	fda.gov/media/120060/download	fda.gov/media/120060/download	PROPN
amwa-142	185	4	wapner	wapner	PROPN
amwa-142	185	5	j.	j.	PROPN
amwa-142	185	6	how	how	SCONJ
amwa-142	185	7	prescription	prescription	NOUN
amwa-142	185	8	drugs	drug	NOUN
amwa-142	185	9	get	get	VERB
amwa-142	185	10	their	their	PRON
amwa-142	185	11	prices	price	NOUN
amwa-142	185	12	,	,	PUNCT
amwa-142	185	13	explained	explain	VERB
amwa-142	185	14	.	.	PUNCT
amwa-142	186	1	newsweek	newsweek	PROPN
amwa-142	186	2	website	website	NOUN
amwa-142	186	3	.	.	PUNCT
amwa-142	187	1	published	publish	VERB
amwa-142	187	2	april	april	PROPN
amwa-142	187	3	14	14	NUM
amwa-142	187	4	,	,	PUNCT
amwa-142	187	5	2017	2017	NUM
amwa-142	187	6	.	.	PUNCT
amwa-142	188	1	accessed	access	VERB
amwa-142	188	2	january	january	PROPN
amwa-142	188	3	8	8	NUM
amwa-142	188	4	,	,	PUNCT
amwa-142	188	5	2021	2021	NUM
amwa-142	188	6	.	.	PUNCT
amwa-142	189	1	https://	https://	PROPN
amwa-142	189	2	www.newsweek.com/2017/04/14/prescription-drug-pricing-569444	www.newsweek.com/2017/04/14/prescription-drug-pricing-569444	PROPN
amwa-142	189	3	.	.	PUNCT
amwa-142	190	1	html#:~:text	html#:~:text	NOUN
amwa-142	190	2	=	=	SYM
amwa-142	190	3	reimbursement%20is%20the%20amount%20the	reimbursement%20is%20the%20amount%20the	PROPN
amwa-142	190	4	,	,	PUNCT
amwa-142	190	5	as%20a%20	as%20a%20	PROPN
amwa-142	190	6	pharmacy%20benefit%20manager	pharmacy%20benefit%20manager	PROPN
amwa-142	190	7	statistically	statistically	ADV
amwa-142	190	8	speaking	speak	VERB
amwa-142	190	9	mailto:thomas.schindler@boehringer-ingelheim.com	mailto:thomas.schindler@boehringer-ingelheim.com	PROPN
amwa-142	190	10	mailto:bridge@astrazeneca.com	mailto:bridge@astrazeneca.com	PROPN
amwa-142	190	11	https://www.theatlantic.com/health/archive/2017/02/when-evidence-says-no-but-doctors-say-yes/517368/	https://www.theatlantic.com/health/archive/2017/02/when-evidence-says-no-but-doctors-say-yes/517368/	PROPN
amwa-142	190	12	https://www.theatlantic.com/health/archive/2017/02/when-evidence-says-no-but-doctors-say-yes/517368/	https://www.theatlantic.com/health/archive/2017/02/when-evidence-says-no-but-doctors-say-yes/517368/	PROPN
amwa-142	190	13	https://www.theatlantic.com/health/archive/2017/02/when-evidence-says-no-but-doctors-say-yes/517368/	https://www.theatlantic.com/health/archive/2017/02/when-evidence-says-no-but-doctors-say-yes/517368/	PROPN
amwa-142	190	14	https://www.recoverytrial.net/files/recovery-protocol-v12-1-2020-12-16.pdf	https://www.recoverytrial.net/files/recovery-protocol-v12-1-2020-12-16.pdf	PROPN
amwa-142	190	15	https://www.recoverytrial.net/files/recovery-protocol-v12-1-2020-12-16.pdf	https://www.recoverytrial.net/files/recovery-protocol-v12-1-2020-12-16.pdf	PROPN
amwa-142	190	16	https://www.recoverytrial.net/files/recovery-protocol-v12-1-2020-12-16.pdf	https://www.recoverytrial.net/files/recovery-protocol-v12-1-2020-12-16.pdf	PROPN
amwa-142	190	17	https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/solidarity-clinical-trial-for-covid-19-treatments	https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/solidarity-clinical-trial-for-covid-19-treatment	NOUN
amwa-142	190	18	https://www.fda.gov/media/120060/download	https://www.fda.gov/media/120060/download	VERB
amwa-142	190	19	https://www.newsweek.com/2017/04/14/prescription-drug-pricing-569444	https://www.newsweek.com/2017/04/14/prescription-drug-pricing-569444	ADJ
amwa-142	190	20	https://www.newsweek.com/2017/04/14/prescription-drug-pricing-569444.html#:~:text=reimbursement%20is%20the%20amount%20the,as%20a%20pharmacy%20benefit%20manager	https://www.newsweek.com/2017/04/14/prescription-drug-pricing-569444.html#:~:text=reimbursement%20is%20the%20amount%20the,as%20a%20pharmacy%20benefit%20manag	ADJ
amwa-142	190	21	https://ebm.bmj.com/content/early/2020/07/08/bmjebm-2020-111447	https://ebm.bmj.com/content/early/2020/07/08/bmjebm-2020-111447	NOUN