id	sid	tid	token	lemma	pos
amwa-224	1	1	v38	v38	NOUN
amwa-224	1	2	n2	n2	PROPN
amwa-224	1	3	/	/	SYM
amwa-224	1	4	2023	2023	NUM
amwa-224	1	5	©	©	PROPN
amwa-224	1	6	2023	2023	NUM
amwa-224	1	7	american	american	ADJ
amwa-224	1	8	medical	medical	PROPN
amwa-224	1	9	writers	writers	PROPN
amwa-224	1	10	association	association	PROPN
amwa-224	1	11	.	.	PUNCT
amwa-224	2	1	all	all	DET
amwa-224	2	2	rights	right	NOUN
amwa-224	2	3	reserved	reserve	VERB
amwa-224	2	4	.	.	PUNCT
amwa-224	3	1	issn	issn	PROPN
amwa-224	3	2	2163	2163	NUM
amwa-224	3	3	-	-	SYM
amwa-224	3	4	5315	5315	NUM
amwa-224	3	5	amwajournal.org	amwajournal.org	PRON
amwa-224	3	6	28	28	NUM
amwa-224	3	7	abstract	abstract	ADJ
amwa-224	3	8	antibody	antibody	NOUN
amwa-224	3	9	-	-	PUNCT
amwa-224	3	10	drug	drug	NOUN
amwa-224	3	11	conjugates	conjugate	NOUN
amwa-224	3	12	(	(	PUNCT
amwa-224	3	13	adcs	adcs	ADJ
amwa-224	3	14	)	)	PUNCT
amwa-224	3	15	are	be	AUX
amwa-224	3	16	currently	currently	ADV
amwa-224	3	17	among	among	ADP
amwa-224	3	18	the	the	DET
amwa-224	3	19	fastest	fast	ADJ
amwa-224	3	20	growing	grow	VERB
amwa-224	3	21	drug	drug	NOUN
amwa-224	3	22	classes	class	NOUN
amwa-224	3	23	in	in	ADP
amwa-224	3	24	oncology	oncology	NOUN
amwa-224	3	25	,	,	PUNCT
amwa-224	3	26	combining	combine	VERB
amwa-224	3	27	the	the	DET
amwa-224	3	28	specificity	specificity	NOUN
amwa-224	3	29	and	and	CCONJ
amwa-224	3	30	targeting	target	VERB
amwa-224	3	31	capabilities	capability	NOUN
amwa-224	3	32	of	of	ADP
amwa-224	3	33	monoclonal	monoclonal	NOUN
amwa-224	3	34	antibodies	antibody	NOUN
amwa-224	3	35	(	(	PUNCT
amwa-224	3	36	mabs	mab	NOUN
amwa-224	3	37	)	)	PUNCT
amwa-224	3	38	with	with	ADP
amwa-224	3	39	the	the	DET
amwa-224	3	40	potent	potent	ADJ
amwa-224	3	41	cytotoxicity	cytotoxicity	NOUN
amwa-224	3	42	of	of	ADP
amwa-224	3	43	small	small	ADJ
amwa-224	3	44	molecule	molecule	NOUN
amwa-224	3	45	drugs	drug	NOUN
amwa-224	3	46	.	.	PUNCT
amwa-224	4	1	considered	consider	VERB
amwa-224	4	2	the	the	DET
amwa-224	4	3	“	"	PUNCT
amwa-224	4	4	biological	biological	ADJ
amwa-224	4	5	missiles	missile	NOUN
amwa-224	4	6	”	"	PUNCT
amwa-224	4	7	of	of	ADP
amwa-224	4	8	cancer	cancer	NOUN
amwa-224	4	9	therapy	therapy	NOUN
amwa-224	4	10	,	,	PUNCT
amwa-224	4	11	adcs	adcs	PROPN
amwa-224	4	12	are	be	AUX
amwa-224	4	13	composed	compose	VERB
amwa-224	4	14	of	of	ADP
amwa-224	4	15	3	3	NUM
amwa-224	4	16	key	key	ADJ
amwa-224	4	17	elements	element	NOUN
amwa-224	4	18	:	:	PUNCT
amwa-224	4	19	(	(	PUNCT
amwa-224	4	20	1	1	X
amwa-224	4	21	)	)	PUNCT
amwa-224	4	22	a	a	DET
amwa-224	4	23	mab	mab	NOUN
amwa-224	4	24	framework	framework	NOUN
amwa-224	4	25	that	that	PRON
amwa-224	4	26	selectively	selectively	ADV
amwa-224	4	27	binds	bind	VERB
amwa-224	4	28	to	to	ADP
amwa-224	4	29	an	an	DET
amwa-224	4	30	antigen	antigen	NOUN
amwa-224	4	31	on	on	ADP
amwa-224	4	32	the	the	DET
amwa-224	4	33	tumor	tumor	NOUN
amwa-224	4	34	cell	cell	NOUN
amwa-224	4	35	surface	surface	NOUN
amwa-224	4	36	,	,	PUNCT
amwa-224	4	37	(	(	PUNCT
amwa-224	4	38	2	2	X
amwa-224	4	39	)	)	PUNCT
amwa-224	4	40	a	a	DET
amwa-224	4	41	cytotoxic	cytotoxic	ADJ
amwa-224	4	42	drug	drug	NOUN
amwa-224	4	43	payload	payload	NOUN
amwa-224	4	44	,	,	PUNCT
amwa-224	4	45	and	and	CCONJ
amwa-224	4	46	(	(	PUNCT
amwa-224	4	47	3	3	X
amwa-224	4	48	)	)	PUNCT
amwa-224	4	49	a	a	DET
amwa-224	4	50	chemical	chemical	NOUN
amwa-224	4	51	linker	linker	NOUN
amwa-224	4	52	attaching	attach	VERB
amwa-224	4	53	the	the	DET
amwa-224	4	54	2	2	NUM
amwa-224	4	55	entities	entity	NOUN
amwa-224	4	56	.	.	PUNCT
amwa-224	5	1	because	because	SCONJ
amwa-224	5	2	each	each	PRON
amwa-224	5	3	of	of	ADP
amwa-224	5	4	these	these	DET
amwa-224	5	5	components	component	NOUN
amwa-224	5	6	can	can	AUX
amwa-224	5	7	vary	vary	VERB
amwa-224	5	8	widely	widely	ADV
amwa-224	5	9	among	among	ADP
amwa-224	5	10	adcs	adc	NOUN
amwa-224	5	11	,	,	PUNCT
amwa-224	5	12	the	the	DET
amwa-224	5	13	associated	associated	ADJ
amwa-224	5	14	drug	drug	NOUN
amwa-224	5	15	design	design	NOUN
amwa-224	5	16	is	be	AUX
amwa-224	5	17	relatively	relatively	ADV
amwa-224	5	18	complex	complex	ADJ
amwa-224	5	19	,	,	PUNCT
amwa-224	5	20	with	with	ADP
amwa-224	5	21	subtle	subtle	ADJ
amwa-224	5	22	differences	difference	NOUN
amwa-224	5	23	leading	lead	VERB
amwa-224	5	24	to	to	ADP
amwa-224	5	25	immense	immense	ADJ
amwa-224	5	26	diversity	diversity	NOUN
amwa-224	5	27	in	in	ADP
amwa-224	5	28	the	the	DET
amwa-224	5	29	overall	overall	ADJ
amwa-224	5	30	drug	drug	NOUN
amwa-224	5	31	structure	structure	NOUN
amwa-224	5	32	and	and	CCONJ
amwa-224	5	33	associated	associated	ADJ
amwa-224	5	34	pharmacological	pharmacological	ADJ
amwa-224	5	35	and	and	CCONJ
amwa-224	5	36	clinical	clinical	ADJ
amwa-224	5	37	properties	property	NOUN
amwa-224	5	38	.	.	PUNCT
amwa-224	6	1	as	as	ADP
amwa-224	6	2	medical	medical	ADJ
amwa-224	6	3	communication	communication	NOUN
amwa-224	6	4	experts	expert	NOUN
amwa-224	6	5	,	,	PUNCT
amwa-224	6	6	it	it	PRON
amwa-224	6	7	is	be	AUX
amwa-224	6	8	essential	essential	ADJ
amwa-224	6	9	to	to	PART
amwa-224	6	10	have	have	VERB
amwa-224	6	11	a	a	DET
amwa-224	6	12	basic	basic	ADJ
amwa-224	6	13	understanding	understanding	NOUN
amwa-224	6	14	of	of	ADP
amwa-224	6	15	the	the	DET
amwa-224	6	16	various	various	ADJ
amwa-224	6	17	components	component	NOUN
amwa-224	6	18	of	of	ADP
amwa-224	6	19	adc	adc	PROPN
amwa-224	6	20	design	design	NOUN
amwa-224	6	21	and	and	CCONJ
amwa-224	6	22	their	their	PRON
amwa-224	6	23	potential	potential	ADJ
amwa-224	6	24	impact	impact	NOUN
amwa-224	6	25	on	on	ADP
amwa-224	6	26	drug	drug	NOUN
amwa-224	6	27	efficacy	efficacy	NOUN
amwa-224	6	28	,	,	PUNCT
amwa-224	6	29	safety	safety	NOUN
amwa-224	6	30	,	,	PUNCT
amwa-224	6	31	and	and	CCONJ
amwa-224	6	32	capability	capability	NOUN
amwa-224	6	33	in	in	ADP
amwa-224	6	34	targeting	target	VERB
amwa-224	6	35	certain	certain	ADJ
amwa-224	6	36	degrees	degree	NOUN
amwa-224	6	37	of	of	ADP
amwa-224	6	38	antigen	antigen	ADJ
amwa-224	6	39	expression	expression	NOUN
amwa-224	6	40	and	and	CCONJ
amwa-224	6	41	tumor	tumor	NOUN
amwa-224	6	42	types	type	NOUN
amwa-224	6	43	.	.	PUNCT
amwa-224	7	1	this	this	DET
amwa-224	7	2	review	review	NOUN
amwa-224	7	3	aims	aim	VERB
amwa-224	7	4	to	to	PART
amwa-224	7	5	provide	provide	VERB
amwa-224	7	6	a	a	DET
amwa-224	7	7	basic	basic	ADJ
amwa-224	7	8	understanding	understanding	NOUN
amwa-224	7	9	of	of	ADP
amwa-224	7	10	each	each	DET
amwa-224	7	11	component	component	NOUN
amwa-224	7	12	related	relate	VERB
amwa-224	7	13	to	to	ADP
amwa-224	7	14	adc	adc	PROPN
amwa-224	7	15	design	design	NOUN
amwa-224	7	16	and	and	CCONJ
amwa-224	7	17	the	the	DET
amwa-224	7	18	role	role	NOUN
amwa-224	7	19	they	they	PRON
amwa-224	7	20	play	play	VERB
amwa-224	7	21	in	in	ADP
amwa-224	7	22	defining	define	VERB
amwa-224	7	23	the	the	DET
amwa-224	7	24	pharmacological	pharmacological	ADJ
amwa-224	7	25	properties	property	NOUN
amwa-224	7	26	of	of	ADP
amwa-224	7	27	a	a	DET
amwa-224	7	28	particular	particular	ADJ
amwa-224	7	29	adc	adc	PROPN
amwa-224	7	30	.	.	PUNCT
amwa-224	8	1	background	background	PROPN
amwa-224	8	2	first	first	ADV
amwa-224	8	3	proposed	propose	VERB
amwa-224	8	4	by	by	ADP
amwa-224	8	5	paul	paul	PROPN
amwa-224	8	6	ehrlich	ehrlich	PROPN
amwa-224	8	7	in	in	ADP
amwa-224	8	8	the	the	DET
amwa-224	8	9	early	early	ADJ
amwa-224	8	10	1900s	1900s	NUM
amwa-224	8	11	,	,	PUNCT
amwa-224	8	12	the	the	DET
amwa-224	8	13	foundational	foundational	ADJ
amwa-224	8	14	concept	concept	NOUN
amwa-224	8	15	of	of	ADP
amwa-224	8	16	a	a	DET
amwa-224	8	17	“	"	PUNCT
amwa-224	8	18	magic	magic	ADJ
amwa-224	8	19	bullet	bullet	NOUN
amwa-224	8	20	”	"	PUNCT
amwa-224	8	21	as	as	ADP
amwa-224	8	22	a	a	DET
amwa-224	8	23	way	way	NOUN
amwa-224	8	24	to	to	PART
amwa-224	8	25	selectively	selectively	ADV
amwa-224	8	26	transport	transport	VERB
amwa-224	8	27	cytotoxic	cytotoxic	ADJ
amwa-224	8	28	drugs	drug	NOUN
amwa-224	8	29	to	to	ADP
amwa-224	8	30	a	a	DET
amwa-224	8	31	specific	specific	ADJ
amwa-224	8	32	target	target	NOUN
amwa-224	8	33	tissue	tissue	NOUN
amwa-224	8	34	has	have	AUX
amwa-224	8	35	become	become	VERB
amwa-224	8	36	an	an	DET
amwa-224	8	37	ever	ever	ADV
amwa-224	8	38	-	-	PUNCT
amwa-224	8	39	closer	close	ADJ
amwa-224	8	40	reality	reality	NOUN
amwa-224	8	41	,	,	PUNCT
amwa-224	8	42	passing	pass	VERB
amwa-224	8	43	through	through	ADP
amwa-224	8	44	key	key	ADJ
amwa-224	8	45	milestones	milestone	NOUN
amwa-224	8	46	over	over	ADP
amwa-224	8	47	the	the	DET
amwa-224	8	48	last	last	ADJ
amwa-224	8	49	century.1,2	century.1,2	NOUN
amwa-224	8	50	the	the	DET
amwa-224	8	51	development	development	NOUN
amwa-224	8	52	of	of	ADP
amwa-224	8	53	chemotherapy	chemotherapy	NOUN
amwa-224	8	54	in	in	ADP
amwa-224	8	55	the	the	DET
amwa-224	8	56	1940s	1940	NOUN
amwa-224	8	57	was	be	AUX
amwa-224	8	58	a	a	DET
amwa-224	8	59	first	first	ADJ
amwa-224	8	60	major	major	ADJ
amwa-224	8	61	step	step	NOUN
amwa-224	8	62	in	in	ADP
amwa-224	8	63	the	the	DET
amwa-224	8	64	transition	transition	NOUN
amwa-224	8	65	from	from	ADP
amwa-224	8	66	concept	concept	NOUN
amwa-224	8	67	to	to	ADP
amwa-224	8	68	reality.3	reality.3	VERB
amwa-224	8	69	however	however	ADV
amwa-224	8	70	,	,	PUNCT
amwa-224	8	71	the	the	DET
amwa-224	8	72	lack	lack	NOUN
amwa-224	8	73	of	of	ADP
amwa-224	8	74	high	high	ADJ
amwa-224	8	75	-	-	PUNCT
amwa-224	8	76	level	level	NOUN
amwa-224	8	77	specificity	specificity	NOUN
amwa-224	8	78	and	and	CCONJ
amwa-224	8	79	targeting	target	VERB
amwa-224	8	80	capabilities	capability	NOUN
amwa-224	8	81	with	with	ADP
amwa-224	8	82	cytotoxic	cytotoxic	ADJ
amwa-224	8	83	agents	agent	NOUN
amwa-224	8	84	led	lead	VERB
amwa-224	8	85	to	to	ADP
amwa-224	8	86	a	a	DET
amwa-224	8	87	high	high	ADJ
amwa-224	8	88	degree	degree	NOUN
amwa-224	8	89	of	of	ADP
amwa-224	8	90	systemic	systemic	ADJ
amwa-224	8	91	toxicities	toxicity	NOUN
amwa-224	8	92	and	and	CCONJ
amwa-224	8	93	has	have	AUX
amwa-224	8	94	remained	remain	VERB
amwa-224	8	95	an	an	DET
amwa-224	8	96	ongoing	ongoing	ADJ
amwa-224	8	97	challenge	challenge	NOUN
amwa-224	8	98	.	.	PUNCT
amwa-224	9	1	the	the	DET
amwa-224	9	2	advent	advent	NOUN
amwa-224	9	3	of	of	ADP
amwa-224	9	4	hybridoma	hybridoma	NOUN
amwa-224	9	5	technology	technology	NOUN
amwa-224	9	6	and	and	CCONJ
amwa-224	9	7	the	the	DET
amwa-224	9	8	development	development	NOUN
amwa-224	9	9	of	of	ADP
amwa-224	9	10	monoclonal	monoclonal	NOUN
amwa-224	9	11	antibodies	antibody	NOUN
amwa-224	9	12	(	(	PUNCT
amwa-224	9	13	mabs	mab	NOUN
amwa-224	9	14	)	)	PUNCT
amwa-224	9	15	in	in	ADP
amwa-224	9	16	the	the	DET
amwa-224	9	17	1970s	1970	NOUN
amwa-224	9	18	established	establish	VERB
amwa-224	9	19	a	a	DET
amwa-224	9	20	highly	highly	ADV
amwa-224	9	21	effective	effective	ADJ
amwa-224	9	22	method	method	NOUN
amwa-224	9	23	for	for	ADP
amwa-224	9	24	targeting	target	VERB
amwa-224	9	25	specific	specific	ADJ
amwa-224	9	26	antigens	antigen	NOUN
amwa-224	9	27	expressed	express	VERB
amwa-224	9	28	on	on	ADP
amwa-224	9	29	the	the	DET
amwa-224	9	30	tumor	tumor	NOUN
amwa-224	9	31	cell	cell	NOUN
amwa-224	9	32	surface.1,4,5	surface.1,4,5	NOUN
amwa-224	9	33	this	this	PRON
amwa-224	9	34	led	lead	VERB
amwa-224	9	35	to	to	ADP
amwa-224	9	36	the	the	DET
amwa-224	9	37	development	development	NOUN
amwa-224	9	38	of	of	ADP
amwa-224	9	39	targeted	target	VERB
amwa-224	9	40	therapeutics	therapeutic	NOUN
amwa-224	9	41	that	that	PRON
amwa-224	9	42	have	have	AUX
amwa-224	9	43	become	become	VERB
amwa-224	9	44	an	an	DET
amwa-224	9	45	attractive	attractive	ADJ
amwa-224	9	46	method	method	NOUN
amwa-224	9	47	for	for	ADP
amwa-224	9	48	improving	improve	VERB
amwa-224	9	49	tumor	tumor	NOUN
amwa-224	9	50	selectivity	selectivity	NOUN
amwa-224	9	51	and	and	CCONJ
amwa-224	9	52	reducing	reduce	VERB
amwa-224	9	53	the	the	DET
amwa-224	9	54	systemic	systemic	ADJ
amwa-224	9	55	toxicity	toxicity	NOUN
amwa-224	9	56	associated	associate	VERB
amwa-224	9	57	with	with	ADP
amwa-224	9	58	traditional	traditional	ADJ
amwa-224	9	59	chemotherapy.6	chemotherapy.6	PROPN
amwa-224	9	60	combining	combine	VERB
amwa-224	9	61	these	these	DET
amwa-224	9	62	2	2	NUM
amwa-224	9	63	technologies	technology	NOUN
amwa-224	9	64	enabled	enable	VERB
amwa-224	9	65	the	the	DET
amwa-224	9	66	development	development	NOUN
amwa-224	9	67	of	of	ADP
amwa-224	9	68	the	the	DET
amwa-224	9	69	first	first	ADJ
amwa-224	9	70	antibody	antibody	NOUN
amwa-224	9	71	-	-	PUNCT
amwa-224	9	72	drug	drug	NOUN
amwa-224	9	73	conjugate	conjugate	NOUN
amwa-224	9	74	(	(	PUNCT
amwa-224	9	75	adc	adc	PROPN
amwa-224	9	76	)	)	PUNCT
amwa-224	9	77	.	.	PUNCT
amwa-224	10	1	in	in	ADP
amwa-224	10	2	recent	recent	ADJ
amwa-224	10	3	decades	decade	NOUN
amwa-224	10	4	,	,	PUNCT
amwa-224	10	5	adcs	adc	NOUN
amwa-224	10	6	have	have	AUX
amwa-224	10	7	become	become	VERB
amwa-224	10	8	a	a	DET
amwa-224	10	9	rapidly	rapidly	ADV
amwa-224	10	10	expanding	expand	VERB
amwa-224	10	11	therapeutic	therapeutic	ADJ
amwa-224	10	12	drug	drug	NOUN
amwa-224	10	13	class	class	NOUN
amwa-224	10	14	specifically	specifically	ADV
amwa-224	10	15	designed	design	VERB
amwa-224	10	16	to	to	PART
amwa-224	10	17	overcome	overcome	VERB
amwa-224	10	18	the	the	DET
amwa-224	10	19	shortfalls	shortfall	NOUN
amwa-224	10	20	associated	associate	VERB
amwa-224	10	21	with	with	ADP
amwa-224	10	22	chemotherapeutic	chemotherapeutic	ADJ
amwa-224	10	23	agents.6,7	agents.6,7	NOUN
amwa-224	10	24	currently	currently	ADV
amwa-224	10	25	,	,	PUNCT
amwa-224	10	26	there	there	PRON
amwa-224	10	27	are	be	VERB
amwa-224	10	28	13	13	NUM
amwa-224	10	29	adcs	adc	NOUN
amwa-224	10	30	that	that	PRON
amwa-224	10	31	have	have	AUX
amwa-224	10	32	received	receive	VERB
amwa-224	10	33	us	we	PRON
amwa-224	10	34	food	food	NOUN
amwa-224	10	35	and	and	CCONJ
amwa-224	10	36	drug	drug	PROPN
amwa-224	10	37	administration	administration	NOUN
amwa-224	10	38	approval	approval	NOUN
amwa-224	10	39	for	for	ADP
amwa-224	10	40	various	various	ADJ
amwa-224	10	41	hematological	hematological	NOUN
amwa-224	10	42	and	and	CCONJ
amwa-224	10	43	solid	solid	ADJ
amwa-224	10	44	tumor	tumor	NOUN
amwa-224	10	45	cancers.1,8	cancers.1,8	ADJ
amwa-224	10	46	-	-	SYM
amwa-224	10	47	20	20	NUM
amwa-224	10	48	adc	adc	NOUN
amwa-224	10	49	mechanism	mechanism	NOUN
amwa-224	10	50	of	of	ADP
amwa-224	10	51	action	action	NOUN
amwa-224	10	52	adcs	adc	NOUN
amwa-224	10	53	are	be	AUX
amwa-224	10	54	a	a	DET
amwa-224	10	55	group	group	NOUN
amwa-224	10	56	of	of	ADP
amwa-224	10	57	tripartite	tripartite	ADJ
amwa-224	10	58	drugs	drug	NOUN
amwa-224	10	59	made	make	VERB
amwa-224	10	60	up	up	ADP
amwa-224	10	61	of	of	ADP
amwa-224	10	62	a	a	DET
amwa-224	10	63	tumor	tumor	NOUN
amwa-224	10	64	specific	specific	ADJ
amwa-224	10	65	mab	mab	NOUN
amwa-224	10	66	conjugated	conjugate	VERB
amwa-224	10	67	via	via	ADP
amwa-224	10	68	a	a	DET
amwa-224	10	69	stable	stable	ADJ
amwa-224	10	70	linker	linker	NOUN
amwa-224	10	71	to	to	ADP
amwa-224	10	72	a	a	DET
amwa-224	10	73	potent	potent	ADJ
amwa-224	10	74	cytotoxic	cytotoxic	ADJ
amwa-224	10	75	payload.21,22	payload.21,22	NOUN
amwa-224	10	76	the	the	DET
amwa-224	10	77	core	core	NOUN
amwa-224	10	78	concept	concept	NOUN
amwa-224	10	79	of	of	ADP
amwa-224	10	80	an	an	DET
amwa-224	10	81	adc	adc	NOUN
amwa-224	10	82	is	be	AUX
amwa-224	10	83	to	to	PART
amwa-224	10	84	use	use	VERB
amwa-224	10	85	the	the	DET
amwa-224	10	86	specific	specific	ADJ
amwa-224	10	87	recognition	recognition	NOUN
amwa-224	10	88	between	between	ADP
amwa-224	10	89	an	an	DET
amwa-224	10	90	antibody	antibody	NOUN
amwa-224	10	91	and	and	CCONJ
amwa-224	10	92	antigen	antigen	NOUN
amwa-224	10	93	to	to	PART
amwa-224	10	94	selectively	selectively	ADV
amwa-224	10	95	deliver	deliver	VERB
amwa-224	10	96	cytotoxic	cytotoxic	ADJ
amwa-224	10	97	drugs	drug	NOUN
amwa-224	10	98	to	to	ADP
amwa-224	10	99	the	the	DET
amwa-224	10	100	tumor	tumor	NOUN
amwa-224	10	101	site	site	NOUN
amwa-224	10	102	,	,	PUNCT
amwa-224	10	103	after	after	ADP
amwa-224	10	104	which	which	PRON
amwa-224	10	105	the	the	DET
amwa-224	10	106	payload	payload	NOUN
amwa-224	10	107	is	be	AUX
amwa-224	10	108	released	release	VERB
amwa-224	10	109	in	in	ADP
amwa-224	10	110	the	the	DET
amwa-224	10	111	tumor	tumor	NOUN
amwa-224	10	112	via	via	ADP
amwa-224	10	113	a	a	DET
amwa-224	10	114	specific	specific	ADJ
amwa-224	10	115	release	release	NOUN
amwa-224	10	116	mechanism.23	mechanism.23	PROPN
amwa-224	10	117	the	the	DET
amwa-224	10	118	general	general	ADJ
amwa-224	10	119	mechanism	mechanism	NOUN
amwa-224	10	120	of	of	ADP
amwa-224	10	121	action	action	NOUN
amwa-224	10	122	for	for	ADP
amwa-224	10	123	an	an	DET
amwa-224	10	124	adc	adc	PROPN
amwa-224	10	125	can	can	AUX
amwa-224	10	126	vary	vary	VERB
amwa-224	10	127	depending	depend	VERB
amwa-224	10	128	on	on	ADP
amwa-224	10	129	the	the	DET
amwa-224	10	130	inherent	inherent	ADJ
amwa-224	10	131	design	design	NOUN
amwa-224	10	132	(	(	PUNCT
amwa-224	10	133	figure	figure	NOUN
amwa-224	10	134	1	1	NUM
amwa-224	10	135	,	,	PUNCT
amwa-224	10	136	next	next	ADJ
amwa-224	10	137	page	page	NOUN
amwa-224	10	138	)	)	PUNCT
amwa-224	10	139	.	.	PUNCT
amwa-224	11	1	adc	adc	PROPN
amwa-224	11	2	design	design	VERB
amwa-224	11	3	the	the	DET
amwa-224	11	4	clinical	clinical	ADJ
amwa-224	11	5	success	success	NOUN
amwa-224	11	6	achieved	achieve	VERB
amwa-224	11	7	with	with	ADP
amwa-224	11	8	a	a	DET
amwa-224	11	9	particular	particular	ADJ
amwa-224	11	10	adc	adc	NOUN
amwa-224	11	11	is	be	AUX
amwa-224	11	12	contingent	contingent	ADJ
amwa-224	11	13	upon	upon	SCONJ
amwa-224	11	14	several	several	ADJ
amwa-224	11	15	key	key	ADJ
amwa-224	11	16	factors	factor	NOUN
amwa-224	11	17	:	:	PUNCT
amwa-224	11	18	(	(	PUNCT
amwa-224	11	19	1	1	X
amwa-224	11	20	)	)	PUNCT
amwa-224	11	21	target	target	NOUN
amwa-224	11	22	antigen	antigen	ADV
amwa-224	11	23	,	,	PUNCT
amwa-224	11	24	(	(	PUNCT
amwa-224	11	25	2	2	X
amwa-224	11	26	)	)	PUNCT
amwa-224	11	27	antibody	antibody	NOUN
amwa-224	11	28	framework	framework	NOUN
amwa-224	11	29	,	,	PUNCT
amwa-224	11	30	(	(	PUNCT
amwa-224	11	31	3	3	X
amwa-224	11	32	)	)	PUNCT
amwa-224	11	33	method	method	NOUN
amwa-224	11	34	of	of	ADP
amwa-224	11	35	conjugation	conjugation	NOUN
amwa-224	11	36	,	,	PUNCT
amwa-224	11	37	(	(	PUNCT
amwa-224	11	38	4	4	X
amwa-224	11	39	)	)	PUNCT
amwa-224	11	40	chemical	chemical	NOUN
amwa-224	11	41	linker	linker	NOUN
amwa-224	11	42	,	,	PUNCT
amwa-224	11	43	and	and	CCONJ
amwa-224	11	44	(	(	PUNCT
amwa-224	11	45	5	5	X
amwa-224	11	46	)	)	PUNCT
amwa-224	11	47	cytotoxic	cytotoxic	ADJ
amwa-224	11	48	payload	payload	NOUN
amwa-224	11	49	(	(	PUNCT
amwa-224	11	50	table	table	NOUN
amwa-224	11	51	1	1	NUM
amwa-224	11	52	,	,	PUNCT
amwa-224	11	53	next	next	ADJ
amwa-224	11	54	page	page	NOUN
amwa-224	11	55	)	)	PUNCT
amwa-224	11	56	.	.	PUNCT
amwa-224	12	1	target	target	VERB
amwa-224	12	2	antigen	antigen	ADV
amwa-224	12	3	to	to	PART
amwa-224	12	4	achieve	achieve	VERB
amwa-224	12	5	a	a	DET
amwa-224	12	6	favorable	favorable	ADJ
amwa-224	12	7	therapeutic	therapeutic	ADJ
amwa-224	12	8	index	index	NOUN
amwa-224	12	9	and	and	CCONJ
amwa-224	12	10	reduce	reduce	VERB
amwa-224	12	11	the	the	DET
amwa-224	12	12	potential	potential	NOUN
amwa-224	12	13	for	for	ADP
amwa-224	12	14	off	off	ADP
amwa-224	12	15	-	-	PUNCT
amwa-224	12	16	target	target	NOUN
amwa-224	12	17	toxicity	toxicity	NOUN
amwa-224	12	18	,	,	PUNCT
amwa-224	12	19	the	the	DET
amwa-224	12	20	selected	select	VERB
amwa-224	12	21	target	target	NOUN
amwa-224	12	22	antigen	antigen	NOUN
amwa-224	12	23	should	should	AUX
amwa-224	12	24	be	be	AUX
amwa-224	12	25	tumor	tumor	NOUN
amwa-224	12	26	-	-	PUNCT
amwa-224	12	27	specific	specific	ADJ
amwa-224	12	28	or	or	CCONJ
amwa-224	12	29	tumor	tumor	NOUN
amwa-224	12	30	-	-	PUNCT
amwa-224	12	31	associated	associate	VERB
amwa-224	12	32	with	with	ADP
amwa-224	12	33	a	a	DET
amwa-224	12	34	high	high	ADJ
amwa-224	12	35	level	level	NOUN
amwa-224	12	36	of	of	ADP
amwa-224	12	37	expression	expression	NOUN
amwa-224	12	38	in	in	ADP
amwa-224	12	39	tumor	tumor	NOUN
amwa-224	12	40	cells	cell	NOUN
amwa-224	12	41	and	and	CCONJ
amwa-224	12	42	minimal	minimal	ADJ
amwa-224	12	43	to	to	ADP
amwa-224	12	44	no	no	DET
amwa-224	12	45	expression	expression	NOUN
amwa-224	12	46	in	in	ADP
amwa-224	12	47	healthy	healthy	ADJ
amwa-224	12	48	tissues.24,28	tissues.24,28	NOUN
amwa-224	12	49	following	follow	VERB
amwa-224	12	50	adc	adc	PROPN
amwa-224	12	51	binding	bind	VERB
amwa-224	12	52	,	,	PUNCT
amwa-224	12	53	target	target	NOUN
amwa-224	12	54	antigens	antigen	NOUN
amwa-224	12	55	should	should	AUX
amwa-224	12	56	internalize	internalize	VERB
amwa-224	12	57	efficiently	efficiently	ADV
amwa-224	12	58	via	via	ADP
amwa-224	12	59	endocytosis	endocytosis	NOUN
amwa-224	12	60	to	to	PART
amwa-224	12	61	enable	enable	VERB
amwa-224	12	62	adc	adc	PROPN
amwa-224	12	63	entry	entry	NOUN
amwa-224	12	64	into	into	ADP
amwa-224	12	65	the	the	DET
amwa-224	12	66	cell	cell	NOUN
amwa-224	12	67	and	and	CCONJ
amwa-224	12	68	subsequent	subsequent	ADJ
amwa-224	12	69	cellular	cellular	ADJ
amwa-224	12	70	transport	transport	NOUN
amwa-224	12	71	and	and	CCONJ
amwa-224	12	72	payload	payload	NOUN
amwa-224	12	73	release.1,21,29	release.1,21,29	NOUN
amwa-224	12	74	the	the	DET
amwa-224	12	75	target	target	NOUN
amwa-224	12	76	antigen	antigen	NOUN
amwa-224	12	77	should	should	AUX
amwa-224	12	78	also	also	ADV
amwa-224	12	79	undergo	undergo	VERB
amwa-224	12	80	efficient	efficient	ADJ
amwa-224	12	81	recycling	recycling	NOUN
amwa-224	12	82	or	or	CCONJ
amwa-224	12	83	replenishment	replenishment	NOUN
amwa-224	12	84	on	on	ADP
amwa-224	12	85	the	the	DET
amwa-224	12	86	cell	cell	NOUN
amwa-224	12	87	surface	surface	NOUN
amwa-224	12	88	with	with	ADP
amwa-224	12	89	no	no	DET
amwa-224	12	90	associated	associated	ADJ
amwa-224	12	91	antigen	antigen	NOUN
amwa-224	12	92	shedding	shed	VERB
amwa-224	12	93	into	into	ADP
amwa-224	12	94	jason	jason	PROPN
amwa-224	12	95	r.	r.	PROPN
amwa-224	12	96	lewis	lewis	PROPN
amwa-224	12	97	,	,	PUNCT
amwa-224	12	98	pharmd	pharmd	PROPN
amwa-224	12	99	,	,	PUNCT
amwa-224	12	100	ms	ms	PROPN
amwa-224	12	101	,	,	PUNCT
amwa-224	12	102	mba	mba	PROPN
amwa-224	12	103	,	,	PUNCT
amwa-224	12	104	bcacp	bcacp	PROPN
amwa-224	12	105	/	/	SYM
amwa-224	12	106	lrx	lrx	PROPN
amwa-224	12	107	precision	precision	NOUN
amwa-224	12	108	health	health	NOUN
amwa-224	12	109	consulting	consulting	NOUN
amwa-224	12	110	and	and	CCONJ
amwa-224	12	111	medical	medical	ADJ
amwa-224	12	112	communication	communication	NOUN
amwa-224	12	113	services	service	NOUN
amwa-224	12	114	,	,	PUNCT
amwa-224	12	115	nephi	nephi	PROPN
amwa-224	12	116	,	,	PUNCT
amwa-224	12	117	ut	ut	ADV
amwa-224	12	118	antibody	antibody	NOUN
amwa-224	12	119	-	-	PUNCT
amwa-224	12	120	drug	drug	NOUN
amwa-224	12	121	conjugates	conjugate	NOUN
amwa-224	12	122	:	:	PUNCT
amwa-224	12	123	understanding	understand	VERB
amwa-224	12	124	associated	associated	ADJ
amwa-224	12	125	drug	drug	NOUN
amwa-224	12	126	design	design	NOUN
amwa-224	12	127	and	and	CCONJ
amwa-224	12	128	pharmacology	pharmacology	NOUN
amwa-224	12	129	science	science	NOUN
amwa-224	12	130	series	series	PROPN
amwa-224	12	131	http://www.amwajournal.org	http://www.amwajournal.org	PROPN
amwa-224	12	132	amwajournal.org	amwajournal.org	X
amwa-224	12	133	29antibody	29antibody	NUM
amwa-224	12	134	-	-	PUNCT
amwa-224	12	135	drug	drug	NOUN
amwa-224	12	136	conjugates	conjugate	NOUN
amwa-224	12	137	figure	figure	VERB
amwa-224	12	138	1	1	NUM
amwa-224	12	139	.	.	PUNCT
amwa-224	12	140	general	general	ADJ
amwa-224	12	141	mechanism	mechanism	NOUN
amwa-224	12	142	of	of	ADP
amwa-224	12	143	action	action	NOUN
amwa-224	12	144	of	of	ADP
amwa-224	12	145	adcs	adcs	NOUN
amwa-224	12	146	with	with	ADP
amwa-224	12	147	and	and	CCONJ
amwa-224	12	148	without	without	ADP
amwa-224	12	149	bystander	bystander	NOUN
amwa-224	12	150	killing	kill	VERB
amwa-224	12	151	effect.5,21	effect.5,21	PROPN
amwa-224	12	152	-	-	PUNCT
amwa-224	12	153	23	23	NUM
amwa-224	12	154	following	follow	VERB
amwa-224	12	155	introduction	introduction	NOUN
amwa-224	12	156	of	of	ADP
amwa-224	12	157	the	the	DET
amwa-224	12	158	antibody	antibody	NOUN
amwa-224	12	159	-	-	PUNCT
amwa-224	12	160	drug	drug	NOUN
amwa-224	12	161	conjugate	conjugate	NOUN
amwa-224	12	162	(	(	PUNCT
amwa-224	12	163	adc	adc	PROPN
amwa-224	12	164	)	)	PUNCT
amwa-224	12	165	into	into	ADP
amwa-224	12	166	the	the	DET
amwa-224	12	167	plasma	plasma	NOUN
amwa-224	12	168	circulation	circulation	NOUN
amwa-224	12	169	by	by	ADP
amwa-224	12	170	intravenous	intravenous	ADJ
amwa-224	12	171	injection	injection	NOUN
amwa-224	12	172	,	,	PUNCT
amwa-224	12	173	the	the	DET
amwa-224	12	174	target	target	NOUN
amwa-224	12	175	antigen	antigen	NOUN
amwa-224	12	176	is	be	AUX
amwa-224	12	177	recognized	recognize	VERB
amwa-224	12	178	on	on	ADP
amwa-224	12	179	the	the	DET
amwa-224	12	180	tumor	tumor	NOUN
amwa-224	12	181	cell	cell	NOUN
amwa-224	12	182	surface	surface	NOUN
amwa-224	12	183	,	,	PUNCT
amwa-224	12	184	leading	lead	VERB
amwa-224	12	185	to	to	ADP
amwa-224	12	186	subsequent	subsequent	ADJ
amwa-224	12	187	binding	binding	NOUN
amwa-224	12	188	and	and	CCONJ
amwa-224	12	189	formation	formation	NOUN
amwa-224	12	190	of	of	ADP
amwa-224	12	191	an	an	DET
amwa-224	12	192	antigen	antigen	ADJ
amwa-224	12	193	–	–	PUNCT
amwa-224	12	194	adc	adc	NOUN
amwa-224	12	195	complex	complex	NOUN
amwa-224	12	196	(	(	PUNCT
amwa-224	12	197	adcc	adcc	NOUN
amwa-224	12	198	)	)	PUNCT
amwa-224	12	199	.	.	PUNCT
amwa-224	13	1	the	the	DET
amwa-224	13	2	complex	complex	NOUN
amwa-224	13	3	is	be	AUX
amwa-224	13	4	then	then	ADV
amwa-224	13	5	internalized	internalize	VERB
amwa-224	13	6	via	via	ADP
amwa-224	13	7	receptor	receptor	NOUN
amwa-224	13	8	-	-	PUNCT
amwa-224	13	9	mediated	mediate	VERB
amwa-224	13	10	endocytosis	endocytosis	NOUN
amwa-224	13	11	.	.	PUNCT
amwa-224	14	1	for	for	ADP
amwa-224	14	2	adcs	adcs	ADJ
amwa-224	14	3	with	with	ADP
amwa-224	14	4	cleavable	cleavable	ADJ
amwa-224	14	5	linker	linker	NOUN
amwa-224	14	6	design	design	NOUN
amwa-224	14	7	,	,	PUNCT
amwa-224	14	8	some	some	DET
amwa-224	14	9	initial	initial	ADJ
amwa-224	14	10	release	release	NOUN
amwa-224	14	11	of	of	ADP
amwa-224	14	12	drug	drug	NOUN
amwa-224	14	13	payload	payload	NOUN
amwa-224	14	14	may	may	AUX
amwa-224	14	15	occur	occur	VERB
amwa-224	14	16	prior	prior	ADV
amwa-224	14	17	to	to	ADP
amwa-224	14	18	internalization	internalization	NOUN
amwa-224	14	19	.	.	PUNCT
amwa-224	15	1	once	once	ADV
amwa-224	15	2	inside	inside	ADP
amwa-224	15	3	the	the	DET
amwa-224	15	4	cytosol	cytosol	NOUN
amwa-224	15	5	,	,	PUNCT
amwa-224	15	6	endosome	endosome	NOUN
amwa-224	15	7	,	,	PUNCT
amwa-224	15	8	or	or	CCONJ
amwa-224	15	9	lysosome	lysosome	PROPN
amwa-224	15	10	,	,	PUNCT
amwa-224	15	11	the	the	DET
amwa-224	15	12	chemical	chemical	NOUN
amwa-224	15	13	characteristics	characteristic	NOUN
amwa-224	15	14	of	of	ADP
amwa-224	15	15	these	these	DET
amwa-224	15	16	environments	environment	NOUN
amwa-224	15	17	(	(	PUNCT
amwa-224	15	18	eg	eg	NOUN
amwa-224	15	19	,	,	PUNCT
amwa-224	15	20	low	low	ADJ
amwa-224	15	21	ph	ph	ADJ
amwa-224	15	22	,	,	PUNCT
amwa-224	15	23	high	high	ADJ
amwa-224	15	24	glutathione	glutathione	NOUN
amwa-224	15	25	/	/	SYM
amwa-224	15	26	thiol	thiol	NOUN
amwa-224	15	27	levels	level	NOUN
amwa-224	15	28	,	,	PUNCT
amwa-224	15	29	proteolytic	proteolytic	ADJ
amwa-224	15	30	enzymes	enzyme	NOUN
amwa-224	15	31	)	)	PUNCT
amwa-224	15	32	allow	allow	VERB
amwa-224	15	33	for	for	ADP
amwa-224	15	34	further	further	ADJ
amwa-224	15	35	payload	payload	NOUN
amwa-224	15	36	release	release	NOUN
amwa-224	15	37	.	.	PUNCT
amwa-224	16	1	in	in	ADP
amwa-224	16	2	the	the	DET
amwa-224	16	3	case	case	NOUN
amwa-224	16	4	of	of	ADP
amwa-224	16	5	adcs	adcs	ADJ
amwa-224	16	6	with	with	ADP
amwa-224	16	7	noncleavable	noncleavable	ADJ
amwa-224	16	8	linker	linker	NOUN
amwa-224	16	9	design	design	NOUN
amwa-224	16	10	,	,	PUNCT
amwa-224	16	11	compete	compete	VERB
amwa-224	16	12	degradation	degradation	NOUN
amwa-224	16	13	of	of	ADP
amwa-224	16	14	the	the	DET
amwa-224	16	15	adc	adc	PROPN
amwa-224	16	16	is	be	AUX
amwa-224	16	17	typically	typically	ADV
amwa-224	16	18	required	require	VERB
amwa-224	16	19	for	for	ADP
amwa-224	16	20	payload	payload	NOUN
amwa-224	16	21	release	release	NOUN
amwa-224	16	22	.	.	PUNCT
amwa-224	17	1	the	the	DET
amwa-224	17	2	resulting	result	VERB
amwa-224	17	3	free	free	ADJ
amwa-224	17	4	cytotoxic	cytotoxic	ADJ
amwa-224	17	5	drug	drug	NOUN
amwa-224	17	6	payload	payload	NOUN
amwa-224	17	7	then	then	ADV
amwa-224	17	8	exerts	exert	VERB
amwa-224	17	9	its	its	PRON
amwa-224	17	10	cellular	cellular	ADJ
amwa-224	17	11	destruction	destruction	NOUN
amwa-224	17	12	via	via	ADP
amwa-224	17	13	a	a	DET
amwa-224	17	14	pathway	pathway	NOUN
amwa-224	17	15	-	-	PUNCT
amwa-224	17	16	specific	specific	ADJ
amwa-224	17	17	mechanism	mechanism	NOUN
amwa-224	17	18	(	(	PUNCT
amwa-224	17	19	eg	eg	NOUN
amwa-224	17	20	,	,	PUNCT
amwa-224	17	21	microtubule	microtubule	NOUN
amwa-224	17	22	disruption	disruption	NOUN
amwa-224	17	23	,	,	PUNCT
amwa-224	17	24	dna	dna	NOUN
amwa-224	17	25	intercalation	intercalation	NOUN
amwa-224	17	26	)	)	PUNCT
amwa-224	17	27	.	.	PUNCT
amwa-224	18	1	hydrophobic	hydrophobic	NOUN
amwa-224	18	2	or	or	CCONJ
amwa-224	18	3	nonpolar	nonpolar	ADJ
amwa-224	18	4	payloads	payload	NOUN
amwa-224	18	5	are	be	AUX
amwa-224	18	6	capable	capable	ADJ
amwa-224	18	7	of	of	ADP
amwa-224	18	8	crossing	cross	VERB
amwa-224	18	9	cell	cell	NOUN
amwa-224	18	10	membranes	membrane	NOUN
amwa-224	18	11	,	,	PUNCT
amwa-224	18	12	thereby	thereby	ADV
amwa-224	18	13	exerting	exert	VERB
amwa-224	18	14	a	a	DET
amwa-224	18	15	so	so	ADV
amwa-224	18	16	-	-	PUNCT
amwa-224	18	17	called	call	VERB
amwa-224	18	18	bystander	bystander	NOUN
amwa-224	18	19	effect	effect	NOUN
amwa-224	18	20	.	.	PUNCT
amwa-224	19	1	the	the	DET
amwa-224	19	2	bystander	bystander	NOUN
amwa-224	19	3	killing	kill	VERB
amwa-224	19	4	effect	effect	NOUN
amwa-224	19	5	involves	involve	VERB
amwa-224	19	6	the	the	DET
amwa-224	19	7	diffusion	diffusion	NOUN
amwa-224	19	8	of	of	ADP
amwa-224	19	9	free	free	ADJ
amwa-224	19	10	drug	drug	NOUN
amwa-224	19	11	across	across	ADP
amwa-224	19	12	cell	cell	NOUN
amwa-224	19	13	membranes	membrane	NOUN
amwa-224	19	14	from	from	ADP
amwa-224	19	15	the	the	DET
amwa-224	19	16	target	target	NOUN
amwa-224	19	17	tumor	tumor	NOUN
amwa-224	19	18	cell	cell	NOUN
amwa-224	19	19	and	and	CCONJ
amwa-224	19	20	into	into	ADP
amwa-224	19	21	neighboring	neighbor	VERB
amwa-224	19	22	tumor	tumor	NOUN
amwa-224	19	23	cells	cell	NOUN
amwa-224	19	24	,	,	PUNCT
amwa-224	19	25	thereby	thereby	ADV
amwa-224	19	26	expanding	expand	VERB
amwa-224	19	27	antitumor	antitumor	PROPN
amwa-224	19	28	activity	activity	NOUN
amwa-224	19	29	to	to	ADP
amwa-224	19	30	tumor	tumor	NOUN
amwa-224	19	31	cells	cell	NOUN
amwa-224	19	32	with	with	ADP
amwa-224	19	33	low	low	ADJ
amwa-224	19	34	or	or	CCONJ
amwa-224	19	35	no	no	PRON
amwa-224	19	36	target	target	NOUN
amwa-224	19	37	antigen	antigen	NOUN
amwa-224	19	38	expression	expression	NOUN
amwa-224	19	39	,	,	PUNCT
amwa-224	19	40	or	or	CCONJ
amwa-224	19	41	those	those	PRON
amwa-224	19	42	that	that	PRON
amwa-224	19	43	are	be	AUX
amwa-224	19	44	less	less	ADV
amwa-224	19	45	accessible	accessible	ADJ
amwa-224	19	46	directly	directly	ADV
amwa-224	19	47	from	from	ADP
amwa-224	19	48	the	the	DET
amwa-224	19	49	circulatory	circulatory	ADJ
amwa-224	19	50	system	system	NOUN
amwa-224	19	51	,	,	PUNCT
amwa-224	19	52	eg	eg	NOUN
amwa-224	19	53	,	,	PUNCT
amwa-224	19	54	solid	solid	ADJ
amwa-224	19	55	tumor	tumor	NOUN
amwa-224	19	56	cells	cell	NOUN
amwa-224	19	57	.	.	PUNCT
amwa-224	20	1	ag	ag	PROPN
amwa-224	20	2	,	,	PUNCT
amwa-224	20	3	antigen	antigen	PROPN
amwa-224	20	4	.	.	PUNCT
amwa-224	21	1	table	table	NOUN
amwa-224	21	2	1	1	NUM
amwa-224	21	3	.	.	PUNCT
amwa-224	22	1	components	component	NOUN
amwa-224	22	2	of	of	ADP
amwa-224	22	3	adc	adc	PROPN
amwa-224	22	4	drug	drug	NOUN
amwa-224	22	5	design1,7,25,26table	design1,7,25,26table	ADJ
amwa-224	22	6	1	1	NUM
amwa-224	22	7	.	.	PUNCT
amwa-224	23	1	components	component	NOUN
amwa-224	23	2	of	of	ADP
amwa-224	23	3	adc	adc	PROPN
amwa-224	23	4	drug	drug	NOUN
amwa-224	23	5	design1,7,25,26	design1,7,25,26	NOUN
amwa-224	23	6	target	target	VERB
amwa-224	23	7	antigen	antigen	ADJ
amwa-224	23	8	antibody	antibody	NOUN
amwa-224	23	9	framework	framework	NOUN
amwa-224	23	10	method	method	NOUN
amwa-224	23	11	of	of	ADP
amwa-224	23	12	conjugation	conjugation	NOUN
amwa-224	23	13	chemical	chemical	NOUN
amwa-224	23	14	linker	linker	NOUN
amwa-224	23	15	cytotoxic	cytotoxic	ADJ
amwa-224	23	16	payload	payload	NOUN
amwa-224	23	17	ideal	ideal	ADJ
amwa-224	23	18	characteristics	characteristic	NOUN
amwa-224	23	19	•	•	ADV
amwa-224	23	20	highly	highly	ADV
amwa-224	23	21	expressed	express	VERB
amwa-224	23	22	in	in	ADP
amwa-224	23	23	tumor	tumor	NOUN
amwa-224	23	24	cells	cell	NOUN
amwa-224	23	25	•	•	VERB
amwa-224	23	26	homogeneous	homogeneous	ADJ
amwa-224	23	27	expression	expression	NOUN
amwa-224	23	28	in	in	ADP
amwa-224	23	29	tumor	tumor	NOUN
amwa-224	23	30	cells	cell	NOUN
amwa-224	23	31	•	•	VERB
amwa-224	23	32	minimal	minimal	ADJ
amwa-224	23	33	presence	presence	NOUN
amwa-224	23	34	in	in	ADP
amwa-224	23	35	circulation	circulation	NOUN
amwa-224	23	36	and	and	CCONJ
amwa-224	23	37	healthy	healthy	ADJ
amwa-224	23	38	cells	cell	NOUN
amwa-224	23	39	ideal	ideal	ADJ
amwa-224	23	40	characteristics	characteristic	NOUN
amwa-224	23	41	•	•	ADP
amwa-224	23	42	minimal	minimal	ADJ
amwa-224	23	43	cross	cross	NOUN
amwa-224	23	44	reactivity	reactivity	NOUN
amwa-224	23	45	with	with	ADP
amwa-224	23	46	healthy	healthy	ADJ
amwa-224	23	47	tissues	tissue	NOUN
amwa-224	23	48	•	•	ADP
amwa-224	23	49	low	low	ADJ
amwa-224	23	50	immunogenicity	immunogenicity	NOUN
amwa-224	23	51	•	•	NOUN
amwa-224	23	52	strong	strong	ADJ
amwa-224	23	53	binding	bind	VERB
amwa-224	23	54	affinity	affinity	NOUN
amwa-224	23	55	for	for	ADP
amwa-224	23	56	the	the	DET
amwa-224	23	57	target	target	NOUN
amwa-224	23	58	antigen	antigen	ADV
amwa-224	23	59	•	•	ADV
amwa-224	23	60	long	long	ADJ
amwa-224	23	61	pk	pk	VERB
amwa-224	23	62	half	half	ADJ
amwa-224	23	63	-	-	PUNCT
amwa-224	23	64	life	life	NOUN
amwa-224	23	65	conventional	conventional	ADJ
amwa-224	23	66	/	/	SYM
amwa-224	23	67	stochastic	stochastic	ADJ
amwa-224	23	68	•	•	NOUN
amwa-224	23	69	lysine	lysine	NOUN
amwa-224	23	70	sites	site	NOUN
amwa-224	23	71	•	•	VERB
amwa-224	23	72	reduced	reduce	VERB
amwa-224	23	73	cysteine	cysteine	NOUN
amwa-224	23	74	sites	site	NOUN
amwa-224	23	75	site	site	NOUN
amwa-224	23	76	-	-	PUNCT
amwa-224	23	77	specific	specific	ADJ
amwa-224	23	78	•	•	NOUN
amwa-224	23	79	engineered	engineer	VERB
amwa-224	23	80	reactive	reactive	ADJ
amwa-224	23	81	cysteine	cysteine	NOUN
amwa-224	23	82	residues	residue	NOUN
amwa-224	23	83	•	•	X
amwa-224	23	84	disulfide	disulfide	NOUN
amwa-224	23	85	re	re	NOUN
amwa-224	23	86	-	-	NOUN
amwa-224	23	87	bridging	bridging	ADJ
amwa-224	23	88	•	•	ADV
amwa-224	23	89	unnatural	unnatural	ADJ
amwa-224	23	90	amino	amino	ADJ
amwa-224	23	91	acids	acid	NOUN
amwa-224	23	92	•	•	NOUN
amwa-224	23	93	enzyme	enzyme	NOUN
amwa-224	23	94	assisted	assist	VERB
amwa-224	23	95	ligation	ligation	NOUN
amwa-224	23	96	•	•	ADP
amwa-224	23	97	glycan	glycan	NOUN
amwa-224	23	98	remodeling	remodeling	NOUN
amwa-224	23	99	and	and	CCONJ
amwa-224	23	100	glycoconjugation	glycoconjugation	NOUN
amwa-224	23	101	•	•	NOUN
amwa-224	23	102	pclick	pclick	NOUN
amwa-224	23	103	technology	technology	NOUN
amwa-224	23	104	cleavable	cleavable	ADJ
amwa-224	23	105	linkers	linker	NOUN
amwa-224	23	106	chemically	chemically	ADV
amwa-224	23	107	cleavable	cleavable	ADJ
amwa-224	23	108	•	•	NUM
amwa-224	23	109	acid	acid	NOUN
amwa-224	23	110	sensitive	sensitive	ADJ
amwa-224	23	111	•	•	NOUN
amwa-224	23	112	glutathione	glutathione	NOUN
amwa-224	23	113	sensitive	sensitive	ADJ
amwa-224	23	114	enzymatically	enzymatically	ADV
amwa-224	23	115	cleavable	cleavable	ADJ
amwa-224	23	116	•	•	ADP
amwa-224	23	117	peptide	peptide	NOUN
amwa-224	23	118	based	base	VERB
amwa-224	23	119	(	(	PUNCT
amwa-224	23	120	protease	protease	NOUN
amwa-224	23	121	sensitive	sensitive	ADJ
amwa-224	23	122	)	)	PUNCT
amwa-224	23	123	•	•	ADP
amwa-224	23	124	β	β	X
amwa-224	23	125	-	-	ADJ
amwa-224	23	126	glucuronide	glucuronide	ADJ
amwa-224	23	127	based	base	VERB
amwa-224	23	128	•	•	NUM
amwa-224	23	129	phosphate	phosphate	NOUN
amwa-224	23	130	based	base	VERB
amwa-224	23	131	noncleavable	noncleavable	ADJ
amwa-224	23	132	linkers	linker	NOUN
amwa-224	23	133	•	•	ADV
amwa-224	23	134	thioether	thioether	ADV
amwa-224	23	135	(	(	PUNCT
amwa-224	23	136	smcc	smcc	NOUN
amwa-224	23	137	)	)	PUNCT
amwa-224	23	138	•	•	NOUN
amwa-224	23	139	maleimido	maleimido	NOUN
amwa-224	23	140	propionyl	propionyl	NOUN
amwa-224	23	141	•	•	NOUN
amwa-224	23	142	maleimido	maleimido	NOUN
amwa-224	23	143	caproyl	caproyl	VERB
amwa-224	23	144	tubulin	tubulin	NOUN
amwa-224	23	145	inhibitors	inhibitor	NOUN
amwa-224	23	146	•	•	ADP
amwa-224	23	147	auristatins	auristatin	NOUN
amwa-224	23	148	(	(	PUNCT
amwa-224	23	149	eg	eg	NOUN
amwa-224	23	150	,	,	PUNCT
amwa-224	23	151	mmae	mmae	NOUN
amwa-224	23	152	,	,	PUNCT
amwa-224	23	153	mmaf	mmaf	NOUN
amwa-224	23	154	)	)	PUNCT
amwa-224	23	155	•	•	NUM
amwa-224	23	156	maytansinoids	maytansinoid	NOUN
amwa-224	23	157	(	(	PUNCT
amwa-224	23	158	eg	eg	NOUN
amwa-224	23	159	,	,	PUNCT
amwa-224	23	160	dm1	dm1	PROPN
amwa-224	23	161	,	,	PUNCT
amwa-224	23	162	dm4	dm4	ADJ
amwa-224	23	163	)	)	PUNCT
amwa-224	23	164	•	•	ADP
amwa-224	23	165	tubulysins	tubulysin	NOUN
amwa-224	23	166	(	(	PUNCT
amwa-224	23	167	eg	eg	NOUN
amwa-224	23	168	,	,	PUNCT
amwa-224	23	169	tubulysin	tubulysin	NOUN
amwa-224	23	170	a	a	PRON
amwa-224	23	171	)	)	PUNCT
amwa-224	23	172	dna	dna	NOUN
amwa-224	23	173	damaging	damage	VERB
amwa-224	23	174	agents	agent	NOUN
amwa-224	23	175	•	•	NOUN
amwa-224	23	176	calicheamicins	calicheamicin	NOUN
amwa-224	23	177	(	(	PUNCT
amwa-224	23	178	eg	eg	NOUN
amwa-224	23	179	,	,	PUNCT
amwa-224	23	180	ozogamicin	ozogamicin	ADJ
amwa-224	23	181	)	)	PUNCT
amwa-224	23	182	•	•	NUM
amwa-224	23	183	duocarmycins	duocarmycin	NOUN
amwa-224	23	184	(	(	PUNCT
amwa-224	23	185	eg	eg	NOUN
amwa-224	23	186	,	,	PUNCT
amwa-224	23	187	duocarmazine	duocarmazine	NOUN
amwa-224	23	188	)	)	PUNCT
amwa-224	23	189	•	•	NUM
amwa-224	23	190	pyrrolbenzodiazepines	pyrrolbenzodiazepine	NOUN
amwa-224	23	191	•	•	NOUN
amwa-224	23	192	camptothecin	camptothecin	NOUN
amwa-224	23	193	analogues	analogue	NOUN
amwa-224	23	194	(	(	PUNCT
amwa-224	23	195	eg	eg	NOUN
amwa-224	23	196	,	,	PUNCT
amwa-224	23	197	govitecan	govitecan	PROPN
amwa-224	23	198	,	,	PUNCT
amwa-224	23	199	dxd	dxd	PROPN
amwa-224	23	200	)	)	PUNCT
amwa-224	23	201	immunomodulators	immunomodulator	NOUN
amwa-224	23	202	•	•	NOUN
amwa-224	23	203	tlr	tlr	PROPN
amwa-224	23	204	agonists	agonist	NOUN
amwa-224	23	205	•	•	NOUN
amwa-224	23	206	sting	ste	VERB
amwa-224	23	207	agonists	agonist	NOUN
amwa-224	23	208	abbreviations	abbreviation	NOUN
amwa-224	23	209	:	:	PUNCT
amwa-224	23	210	ag	ag	PROPN
amwa-224	23	211	,	,	PUNCT
amwa-224	23	212	antigen	antigen	PROPN
amwa-224	23	213	;	;	PUNCT
amwa-224	23	214	dm1	dm1	PROPN
amwa-224	23	215	,	,	PUNCT
amwa-224	23	216	mertansine	mertansine	PROPN
amwa-224	23	217	;	;	PUNCT
amwa-224	23	218	dm4	dm4	X
amwa-224	23	219	,	,	PUNCT
amwa-224	23	220	ravtansine	ravtansine	NOUN
amwa-224	23	221	;	;	PUNCT
amwa-224	23	222	dxd	dxd	PROPN
amwa-224	23	223	,	,	PUNCT
amwa-224	23	224	deruxtecan	deruxtecan	ADJ
amwa-224	23	225	;	;	PUNCT
amwa-224	23	226	fab	fab	ADJ
amwa-224	23	227	,	,	PUNCT
amwa-224	23	228	fragment	fragment	ADJ
amwa-224	23	229	antigen	antigen	NOUN
amwa-224	23	230	binding	bind	VERB
amwa-224	23	231	;	;	PUNCT
amwa-224	23	232	fc	fc	X
amwa-224	23	233	,	,	PUNCT
amwa-224	23	234	fragment	fragment	NOUN
amwa-224	23	235	crystallized	crystallize	VERB
amwa-224	23	236	;	;	PUNCT
amwa-224	23	237	mmae	mmae	PROPN
amwa-224	23	238	,	,	PUNCT
amwa-224	23	239	monomethyl	monomethyl	NOUN
amwa-224	23	240	auristatin	auristatin	PROPN
amwa-224	23	241	e	e	PROPN
amwa-224	23	242	;	;	PUNCT
amwa-224	23	243	mmaf	mmaf	NOUN
amwa-224	23	244	,	,	PUNCT
amwa-224	23	245	monomethyl	monomethyl	NOUN
amwa-224	23	246	auristatin	auristatin	PROPN
amwa-224	23	247	f	f	PROPN
amwa-224	23	248	;	;	PUNCT
amwa-224	23	249	pk	pk	NOUN
amwa-224	23	250	,	,	PUNCT
amwa-224	23	251	pharmacokinetic	pharmacokinetic	ADJ
amwa-224	23	252	;	;	PUNCT
amwa-224	23	253	smcc	smcc	NOUN
amwa-224	23	254	,	,	PUNCT
amwa-224	23	255	sulfosuccinimidyl	sulfosuccinimidyl	NOUN
amwa-224	23	256	4-(n	4-(n	NUM
amwa-224	23	257	-	-	PUNCT
amwa-224	23	258	maleimidomethyl)cyclohexane-1	maleimidomethyl)cyclohexane-1	NOUN
amwa-224	23	259	-	-	PUNCT
amwa-224	23	260	carbocylate	carbocylate	NOUN
amwa-224	23	261	;	;	PUNCT
amwa-224	23	262	sting	sting	ADJ
amwa-224	23	263	,	,	PUNCT
amwa-224	23	264	stimulator	stimulator	NOUN
amwa-224	23	265	of	of	ADP
amwa-224	23	266	interferon	interferon	ADJ
amwa-224	23	267	genes	gene	NOUN
amwa-224	23	268	;	;	PUNCT
amwa-224	23	269	tlr	tlr	PROPN
amwa-224	23	270	,	,	PUNCT
amwa-224	23	271	toll	toll	NOUN
amwa-224	23	272	-	-	PUNCT
amwa-224	23	273	like	like	ADJ
amwa-224	23	274	receptor	receptor	NOUN
amwa-224	23	275	.	.	PUNCT
amwa-224	23	276	http://www.amwajournal.org	http://www.amwajournal.org	X
amwa-224	24	1	amwajournal.org	amwajournal.org	X
amwa-224	24	2	30antibody	30antibody	NUM
amwa-224	24	3	-	-	PUNCT
amwa-224	24	4	drug	drug	NOUN
amwa-224	24	5	conjugates	conjugate	NOUN
amwa-224	24	6	circulation	circulation	NOUN
amwa-224	24	7	to	to	PART
amwa-224	24	8	improve	improve	VERB
amwa-224	24	9	tumor	tumor	NOUN
amwa-224	24	10	cell	cell	NOUN
amwa-224	24	11	targeting	target	VERB
amwa-224	24	12	and	and	CCONJ
amwa-224	24	13	reduce	reduce	VERB
amwa-224	24	14	the	the	DET
amwa-224	24	15	risk	risk	NOUN
amwa-224	24	16	of	of	ADP
amwa-224	24	17	toxicity.30,31	toxicity.30,31	NOUN
amwa-224	24	18	solid	solid	ADJ
amwa-224	24	19	tumors	tumor	NOUN
amwa-224	24	20	present	present	VERB
amwa-224	24	21	a	a	DET
amwa-224	24	22	challenge	challenge	NOUN
amwa-224	24	23	in	in	ADP
amwa-224	24	24	terms	term	NOUN
amwa-224	24	25	of	of	ADP
amwa-224	24	26	both	both	CCONJ
amwa-224	24	27	the	the	DET
amwa-224	24	28	drug	drug	NOUN
amwa-224	24	29	accessibility	accessibility	NOUN
amwa-224	24	30	and	and	CCONJ
amwa-224	24	31	intratumoral	intratumoral	ADJ
amwa-224	24	32	heterogeneity	heterogeneity	NOUN
amwa-224	24	33	of	of	ADP
amwa-224	24	34	the	the	DET
amwa-224	24	35	target	target	NOUN
amwa-224	24	36	antigen	antigen	ADV
amwa-224	24	37	.	.	PUNCT
amwa-224	25	1	therefore	therefore	ADV
amwa-224	25	2	,	,	PUNCT
amwa-224	25	3	certain	certain	ADJ
amwa-224	25	4	characteristics	characteristic	NOUN
amwa-224	25	5	of	of	ADP
amwa-224	25	6	adc	adc	PROPN
amwa-224	25	7	design	design	NOUN
amwa-224	25	8	,	,	PUNCT
amwa-224	25	9	such	such	ADJ
amwa-224	25	10	as	as	ADP
amwa-224	25	11	cleavable	cleavable	ADJ
amwa-224	25	12	linkers	linker	NOUN
amwa-224	25	13	or	or	CCONJ
amwa-224	25	14	nonpolarized	nonpolarized	ADJ
amwa-224	25	15	payloads	payload	NOUN
amwa-224	25	16	,	,	PUNCT
amwa-224	25	17	which	which	PRON
amwa-224	25	18	permit	permit	VERB
amwa-224	25	19	the	the	DET
amwa-224	25	20	release	release	NOUN
amwa-224	25	21	or	or	CCONJ
amwa-224	25	22	distribution	distribution	NOUN
amwa-224	25	23	of	of	ADP
amwa-224	25	24	drug	drug	NOUN
amwa-224	25	25	to	to	ADP
amwa-224	25	26	neighboring	neighbor	VERB
amwa-224	25	27	tumor	tumor	NOUN
amwa-224	25	28	cells	cell	NOUN
amwa-224	25	29	with	with	ADP
amwa-224	25	30	low	low	ADJ
amwa-224	25	31	or	or	CCONJ
amwa-224	25	32	no	no	PRON
amwa-224	25	33	antigen	antigen	ADJ
amwa-224	25	34	expression	expression	NOUN
amwa-224	25	35	(	(	PUNCT
amwa-224	25	36	the	the	DET
amwa-224	25	37	so	so	ADV
amwa-224	25	38	-	-	PUNCT
amwa-224	25	39	called	call	VERB
amwa-224	25	40	bystander	bystander	NOUN
amwa-224	25	41	effect	effect	NOUN
amwa-224	25	42	)	)	PUNCT
amwa-224	25	43	,	,	PUNCT
amwa-224	25	44	may	may	AUX
amwa-224	25	45	be	be	AUX
amwa-224	25	46	advantageous	advantageous	ADJ
amwa-224	25	47	in	in	ADP
amwa-224	25	48	adcs	adcs	ADJ
amwa-224	25	49	targeting	target	VERB
amwa-224	25	50	these	these	DET
amwa-224	25	51	tumor	tumor	NOUN
amwa-224	25	52	types.31	types.31	NOUN
amwa-224	25	53	antibody	antibody	NOUN
amwa-224	25	54	framework	framework	VERB
amwa-224	25	55	the	the	DET
amwa-224	25	56	antibody	antibody	NOUN
amwa-224	25	57	framework	framework	NOUN
amwa-224	25	58	used	use	VERB
amwa-224	25	59	in	in	ADP
amwa-224	25	60	the	the	DET
amwa-224	25	61	adc	adc	PROPN
amwa-224	25	62	structure	structure	NOUN
amwa-224	25	63	is	be	AUX
amwa-224	25	64	essential	essential	ADJ
amwa-224	25	65	for	for	ADP
amwa-224	25	66	facilitating	facilitate	VERB
amwa-224	25	67	selective	selective	ADJ
amwa-224	25	68	binding	binding	NOUN
amwa-224	25	69	of	of	ADP
amwa-224	25	70	target	target	NOUN
amwa-224	25	71	antigens	antigen	NOUN
amwa-224	25	72	and	and	CCONJ
amwa-224	25	73	can	can	AUX
amwa-224	25	74	significantly	significantly	ADV
amwa-224	25	75	influence	influence	VERB
amwa-224	25	76	the	the	DET
amwa-224	25	77	overall	overall	ADJ
amwa-224	25	78	efficacy	efficacy	NOUN
amwa-224	25	79	,	,	PUNCT
amwa-224	25	80	therapeutic	therapeutic	ADJ
amwa-224	25	81	index	index	NOUN
amwa-224	25	82	,	,	PUNCT
amwa-224	25	83	and	and	CCONJ
amwa-224	25	84	pharmacokinetic	pharmacokinetic	ADJ
amwa-224	25	85	and	and	CCONJ
amwa-224	25	86	pharmacodynamic	pharmacodynamic	ADJ
amwa-224	25	87	characteristics	characteristic	NOUN
amwa-224	25	88	of	of	ADP
amwa-224	25	89	the	the	DET
amwa-224	25	90	end	end	NOUN
amwa-224	25	91	drug	drug	NOUN
amwa-224	25	92	product.1,21	product.1,21	NOUN
amwa-224	25	93	ideally	ideally	ADV
amwa-224	25	94	,	,	PUNCT
amwa-224	25	95	the	the	DET
amwa-224	25	96	selected	select	VERB
amwa-224	25	97	mab	mab	NOUN
amwa-224	25	98	should	should	AUX
amwa-224	25	99	possess	possess	VERB
amwa-224	25	100	a	a	DET
amwa-224	25	101	strong	strong	ADJ
amwa-224	25	102	binding	bind	VERB
amwa-224	25	103	affinity	affinity	NOUN
amwa-224	25	104	with	with	ADP
amwa-224	25	105	high	high	ADJ
amwa-224	25	106	target	target	NOUN
amwa-224	25	107	specificity	specificity	NOUN
amwa-224	25	108	and	and	CCONJ
amwa-224	25	109	minimal	minimal	ADJ
amwa-224	25	110	cross	cross	NOUN
amwa-224	25	111	-	-	NOUN
amwa-224	25	112	reactivity	reactivity	NOUN
amwa-224	25	113	with	with	ADP
amwa-224	25	114	healthy	healthy	ADJ
amwa-224	25	115	tissues.24	tissues.24	NOUN
amwa-224	25	116	the	the	DET
amwa-224	25	117	selected	select	VERB
amwa-224	25	118	mab	mab	NOUN
amwa-224	25	119	should	should	AUX
amwa-224	25	120	also	also	ADV
amwa-224	25	121	facilitate	facilitate	VERB
amwa-224	25	122	efficient	efficient	ADJ
amwa-224	25	123	internalization	internalization	NOUN
amwa-224	25	124	,	,	PUNCT
amwa-224	25	125	demonstrate	demonstrate	VERB
amwa-224	25	126	low	low	ADJ
amwa-224	25	127	immunogenicity	immunogenicity	NOUN
amwa-224	25	128	,	,	PUNCT
amwa-224	25	129	and	and	CCONJ
amwa-224	25	130	have	have	VERB
amwa-224	25	131	a	a	DET
amwa-224	25	132	long	long	ADJ
amwa-224	25	133	half	half	ADJ
amwa-224	25	134	-	-	PUNCT
amwa-224	25	135	life	life	NOUN
amwa-224	25	136	.	.	PUNCT
amwa-224	26	1	among	among	ADP
amwa-224	26	2	the	the	DET
amwa-224	26	3	5	5	NUM
amwa-224	26	4	major	major	ADJ
amwa-224	26	5	subtypes	subtype	NOUN
amwa-224	26	6	of	of	ADP
amwa-224	26	7	human	human	ADJ
amwa-224	26	8	antibodies	antibody	NOUN
amwa-224	26	9	(	(	PUNCT
amwa-224	26	10	eg	eg	NOUN
amwa-224	26	11	,	,	PUNCT
amwa-224	26	12	immunoglobulin	immunoglobulin	NOUN
amwa-224	26	13	[	[	X
amwa-224	26	14	ig]a	ig]a	PROPN
amwa-224	26	15	,	,	PUNCT
amwa-224	26	16	igd	igd	PROPN
amwa-224	26	17	,	,	PUNCT
amwa-224	26	18	ige	ige	PROPN
amwa-224	26	19	,	,	PUNCT
amwa-224	26	20	igg	igg	PROPN
amwa-224	26	21	,	,	PUNCT
amwa-224	26	22	and	and	CCONJ
amwa-224	26	23	igm	igm	PROPN
amwa-224	26	24	)	)	PUNCT
amwa-224	26	25	,	,	PUNCT
amwa-224	26	26	igg	igg	PROPN
amwa-224	26	27	antibodies	antibodie	VERB
amwa-224	26	28	are	be	AUX
amwa-224	26	29	most	most	ADV
amwa-224	26	30	often	often	ADV
amwa-224	26	31	used	use	VERB
amwa-224	26	32	for	for	ADP
amwa-224	26	33	adc	adc	PROPN
amwa-224	26	34	development	development	NOUN
amwa-224	26	35	because	because	SCONJ
amwa-224	26	36	of	of	ADP
amwa-224	26	37	their	their	PRON
amwa-224	26	38	plasma	plasma	NOUN
amwa-224	26	39	stability	stability	NOUN
amwa-224	26	40	and	and	CCONJ
amwa-224	26	41	strong	strong	ADJ
amwa-224	26	42	binding	bind	VERB
amwa-224	26	43	affinity	affinity	NOUN
amwa-224	26	44	for	for	ADP
amwa-224	26	45	the	the	DET
amwa-224	26	46	fragment	fragment	NOUN
amwa-224	26	47	crystallized	crystallize	VERB
amwa-224	26	48	(	(	PUNCT
amwa-224	26	49	fc	fc	INTJ
amwa-224	26	50	)	)	PUNCT
amwa-224	26	51	receptor.1,21,32	receptor.1,21,32	VERB
amwa-224	26	52	moreover	moreover	ADV
amwa-224	26	53	,	,	PUNCT
amwa-224	26	54	because	because	SCONJ
amwa-224	26	55	of	of	ADP
amwa-224	26	56	their	their	PRON
amwa-224	26	57	decreased	decrease	VERB
amwa-224	26	58	potential	potential	NOUN
amwa-224	26	59	for	for	ADP
amwa-224	26	60	immunogenicity	immunogenicity	NOUN
amwa-224	26	61	,	,	PUNCT
amwa-224	26	62	humanized	humanize	VERB
amwa-224	26	63	or	or	CCONJ
amwa-224	26	64	fully	fully	ADV
amwa-224	26	65	human	human	ADJ
amwa-224	26	66	mabs	mab	NOUN
amwa-224	26	67	are	be	AUX
amwa-224	26	68	typically	typically	ADV
amwa-224	26	69	favored	favor	VERB
amwa-224	26	70	in	in	ADP
amwa-224	26	71	adc	adc	PROPN
amwa-224	26	72	design	design	NOUN
amwa-224	26	73	as	as	SCONJ
amwa-224	26	74	opposed	oppose	VERB
amwa-224	26	75	to	to	PART
amwa-224	26	76	murine	murine	ADJ
amwa-224	26	77	or	or	CCONJ
amwa-224	26	78	chimeric	chimeric	ADJ
amwa-224	26	79	mabs	mab	NOUN
amwa-224	26	80	.	.	PUNCT
amwa-224	27	1	method	method	NOUN
amwa-224	27	2	of	of	ADP
amwa-224	27	3	conjugation	conjugation	NOUN
amwa-224	27	4	:	:	PUNCT
amwa-224	27	5	conventional	conventional	ADJ
amwa-224	27	6	the	the	DET
amwa-224	27	7	method	method	NOUN
amwa-224	27	8	of	of	ADP
amwa-224	27	9	conjugation	conjugation	NOUN
amwa-224	27	10	in	in	ADP
amwa-224	27	11	adc	adc	PROPN
amwa-224	27	12	design	design	NOUN
amwa-224	27	13	refers	refer	VERB
amwa-224	27	14	to	to	ADP
amwa-224	27	15	the	the	DET
amwa-224	27	16	approach	approach	NOUN
amwa-224	27	17	used	use	VERB
amwa-224	27	18	to	to	PART
amwa-224	27	19	connect	connect	VERB
amwa-224	27	20	the	the	DET
amwa-224	27	21	linker	linker	NOUN
amwa-224	27	22	and	and	CCONJ
amwa-224	27	23	payload	payload	NOUN
amwa-224	27	24	to	to	ADP
amwa-224	27	25	the	the	DET
amwa-224	27	26	mab	mab	NOUN
amwa-224	27	27	framework.1	framework.1	PROPN
amwa-224	27	28	historically	historically	ADV
amwa-224	27	29	,	,	PUNCT
amwa-224	27	30	conventional	conventional	ADJ
amwa-224	27	31	conjugation	conjugation	NOUN
amwa-224	27	32	methods	method	NOUN
amwa-224	27	33	have	have	AUX
amwa-224	27	34	been	be	AUX
amwa-224	27	35	the	the	PRON
amwa-224	27	36	most	most	ADV
amwa-224	27	37	widely	widely	ADV
amwa-224	27	38	used	use	VERB
amwa-224	27	39	in	in	ADP
amwa-224	27	40	adc	adc	PROPN
amwa-224	27	41	design	design	NOUN
amwa-224	27	42	.	.	PUNCT
amwa-224	28	1	conventional	conventional	ADJ
amwa-224	28	2	conjugation	conjugation	NOUN
amwa-224	28	3	entails	entail	VERB
amwa-224	28	4	either	either	CCONJ
amwa-224	28	5	the	the	DET
amwa-224	28	6	alkylation	alkylation	NOUN
amwa-224	28	7	or	or	CCONJ
amwa-224	28	8	acylation	acylation	NOUN
amwa-224	28	9	of	of	ADP
amwa-224	28	10	lysine	lysine	NOUN
amwa-224	28	11	side	side	NOUN
amwa-224	28	12	chains	chain	NOUN
amwa-224	28	13	or	or	CCONJ
amwa-224	28	14	the	the	DET
amwa-224	28	15	reduction	reduction	NOUN
amwa-224	28	16	of	of	ADP
amwa-224	28	17	disulfide	disulfide	NOUN
amwa-224	28	18	bonds	bond	NOUN
amwa-224	28	19	to	to	PART
amwa-224	28	20	liberate	liberate	VERB
amwa-224	28	21	cysteine	cysteine	NOUN
amwa-224	28	22	residues	residue	NOUN
amwa-224	28	23	for	for	ADP
amwa-224	28	24	conjugation	conjugation	NOUN
amwa-224	28	25	sites.21,33	sites.21,33	NOUN
amwa-224	28	26	notably	notably	ADV
amwa-224	28	27	,	,	PUNCT
amwa-224	28	28	mabs	mab	NOUN
amwa-224	28	29	such	such	ADJ
amwa-224	28	30	as	as	ADP
amwa-224	28	31	igg	igg	PROPN
amwa-224	28	32	contain	contain	VERB
amwa-224	28	33	a	a	DET
amwa-224	28	34	natural	natural	ADJ
amwa-224	28	35	abundance	abundance	NOUN
amwa-224	28	36	of	of	ADP
amwa-224	28	37	lysine	lysine	NOUN
amwa-224	28	38	(	(	PUNCT
amwa-224	28	39	80	80	NUM
amwa-224	28	40	-	-	SYM
amwa-224	28	41	100	100	NUM
amwa-224	28	42	)	)	PUNCT
amwa-224	28	43	and	and	CCONJ
amwa-224	28	44	cysteine	cysteine	NOUN
amwa-224	28	45	(	(	PUNCT
amwa-224	28	46	32	32	NUM
amwa-224	28	47	-	-	SYM
amwa-224	28	48	40	40	NUM
amwa-224	28	49	)	)	PUNCT
amwa-224	28	50	residues	residue	NOUN
amwa-224	28	51	,	,	PUNCT
amwa-224	28	52	which	which	PRON
amwa-224	28	53	offer	offer	VERB
amwa-224	28	54	ideal	ideal	ADJ
amwa-224	28	55	sites	site	NOUN
amwa-224	28	56	for	for	ADP
amwa-224	28	57	linker	linker	NOUN
amwa-224	28	58	attachment	attachment	NOUN
amwa-224	28	59	via	via	ADP
amwa-224	28	60	conventional	conventional	ADJ
amwa-224	28	61	conjugation	conjugation	NOUN
amwa-224	28	62	involving	involve	VERB
amwa-224	28	63	coupling	couple	VERB
amwa-224	28	64	reactions.1,27,33	reactions.1,27,33	NOUN
amwa-224	28	65	-	-	PUNCT
amwa-224	28	66	36	36	NUM
amwa-224	28	67	conventional	conventional	ADJ
amwa-224	28	68	conjugation	conjugation	NOUN
amwa-224	28	69	using	use	VERB
amwa-224	28	70	lysine	lysine	NOUN
amwa-224	28	71	and	and	CCONJ
amwa-224	28	72	cysteine	cysteine	NOUN
amwa-224	28	73	residues	residue	NOUN
amwa-224	28	74	is	be	AUX
amwa-224	28	75	stochastic	stochastic	ADJ
amwa-224	28	76	.	.	PUNCT
amwa-224	29	1	this	this	PRON
amwa-224	29	2	can	can	AUX
amwa-224	29	3	lead	lead	VERB
amwa-224	29	4	to	to	ADP
amwa-224	29	5	heterogeneous	heterogeneous	ADJ
amwa-224	29	6	mixtures	mixture	NOUN
amwa-224	29	7	of	of	ADP
amwa-224	29	8	adc	adc	PROPN
amwa-224	29	9	species	specie	NOUN
amwa-224	29	10	with	with	ADP
amwa-224	29	11	varying	vary	VERB
amwa-224	29	12	sites	site	NOUN
amwa-224	29	13	of	of	ADP
amwa-224	29	14	conjugation	conjugation	NOUN
amwa-224	29	15	and	and	CCONJ
amwa-224	29	16	drug	drug	NOUN
amwa-224	29	17	-	-	PUNCT
amwa-224	29	18	to	to	ADP
amwa-224	29	19	-	-	PUNCT
amwa-224	29	20	antibody	antibody	NOUN
amwa-224	29	21	ratios	ratio	NOUN
amwa-224	29	22	(	(	PUNCT
amwa-224	29	23	dars	dar	NOUN
amwa-224	29	24	)	)	PUNCT
amwa-224	29	25	,	,	PUNCT
amwa-224	29	26	defined	define	VERB
amwa-224	29	27	as	as	SCONJ
amwa-224	29	28	the	the	DET
amwa-224	29	29	number	number	NOUN
amwa-224	29	30	of	of	ADP
amwa-224	29	31	drug	drug	NOUN
amwa-224	29	32	payloads	payload	NOUN
amwa-224	29	33	conjugated	conjugate	VERB
amwa-224	29	34	to	to	ADP
amwa-224	29	35	each	each	DET
amwa-224	29	36	mab.37	mab.37	NOUN
amwa-224	29	37	dars	dar	NOUN
amwa-224	29	38	associated	associate	VERB
amwa-224	29	39	with	with	ADP
amwa-224	29	40	adcs	adc	NOUN
amwa-224	29	41	produced	produce	VERB
amwa-224	29	42	by	by	ADP
amwa-224	29	43	conventional	conventional	ADJ
amwa-224	29	44	conjugation	conjugation	NOUN
amwa-224	29	45	methods	method	NOUN
amwa-224	29	46	often	often	ADV
amwa-224	29	47	vary	vary	VERB
amwa-224	29	48	,	,	PUNCT
amwa-224	29	49	ranging	range	VERB
amwa-224	29	50	from	from	ADP
amwa-224	29	51	0	0	NUM
amwa-224	29	52	to	to	ADP
amwa-224	29	53	8	8	NUM
amwa-224	29	54	or	or	CCONJ
amwa-224	29	55	more.38	more.38	PROPN
amwa-224	29	56	dar	dar	NOUN
amwa-224	29	57	-	-	PUNCT
amwa-224	29	58	associated	associate	VERB
amwa-224	29	59	variability	variability	NOUN
amwa-224	29	60	can	can	AUX
amwa-224	29	61	potentially	potentially	ADV
amwa-224	29	62	impact	impact	VERB
amwa-224	29	63	certain	certain	ADJ
amwa-224	29	64	adc	adc	PROPN
amwa-224	29	65	characteristics	characteristic	NOUN
amwa-224	29	66	,	,	PUNCT
amwa-224	29	67	such	such	ADJ
amwa-224	29	68	as	as	ADP
amwa-224	29	69	hydrophobicity	hydrophobicity	NOUN
amwa-224	29	70	,	,	PUNCT
amwa-224	29	71	charge	charge	NOUN
amwa-224	29	72	,	,	PUNCT
amwa-224	29	73	polarity	polarity	NOUN
amwa-224	29	74	,	,	PUNCT
amwa-224	29	75	pharmacokinetics	pharmacokinetic	NOUN
amwa-224	29	76	,	,	PUNCT
amwa-224	29	77	and	and	CCONJ
amwa-224	29	78	thermostability	thermostability	NOUN
amwa-224	29	79	of	of	ADP
amwa-224	29	80	mabs.38	mabs.38	PROPN
amwa-224	29	81	-	-	PUNCT
amwa-224	29	82	40	40	NUM
amwa-224	29	83	in	in	ADP
amwa-224	29	84	some	some	DET
amwa-224	29	85	cases	case	NOUN
amwa-224	29	86	this	this	PRON
amwa-224	29	87	may	may	AUX
amwa-224	29	88	result	result	VERB
amwa-224	29	89	in	in	ADP
amwa-224	29	90	insufficient	insufficient	ADJ
amwa-224	29	91	stability	stability	NOUN
amwa-224	29	92	,	,	PUNCT
amwa-224	29	93	causing	cause	VERB
amwa-224	29	94	premature	premature	ADJ
amwa-224	29	95	payload	payload	NOUN
amwa-224	29	96	release	release	NOUN
amwa-224	29	97	and	and	CCONJ
amwa-224	29	98	increased	increase	VERB
amwa-224	29	99	potential	potential	NOUN
amwa-224	29	100	for	for	ADP
amwa-224	29	101	off	off	ADP
amwa-224	29	102	-	-	PUNCT
amwa-224	29	103	target	target	NOUN
amwa-224	29	104	toxicities.1	toxicities.1	PROPN
amwa-224	29	105	elevated	elevate	VERB
amwa-224	29	106	dars	dar	NOUN
amwa-224	29	107	can	can	AUX
amwa-224	29	108	also	also	ADV
amwa-224	29	109	lead	lead	VERB
amwa-224	29	110	to	to	ADP
amwa-224	29	111	aggregation	aggregation	NOUN
amwa-224	29	112	,	,	PUNCT
amwa-224	29	113	increased	increase	VERB
amwa-224	29	114	metabolism	metabolism	NOUN
amwa-224	29	115	,	,	PUNCT
amwa-224	29	116	or	or	CCONJ
amwa-224	29	117	disruptive	disruptive	ADJ
amwa-224	29	118	coupling	coupling	NOUN
amwa-224	29	119	within	within	ADP
amwa-224	29	120	the	the	DET
amwa-224	29	121	antigen	antigen	ADJ
amwa-224	29	122	binding	bind	VERB
amwa-224	29	123	region	region	NOUN
amwa-224	29	124	of	of	ADP
amwa-224	29	125	the	the	DET
amwa-224	29	126	mab.21,41,42	mab.21,41,42	PROPN
amwa-224	29	127	because	because	SCONJ
amwa-224	29	128	lysine	lysine	NOUN
amwa-224	29	129	residues	residue	NOUN
amwa-224	29	130	are	be	AUX
amwa-224	29	131	distributed	distribute	VERB
amwa-224	29	132	throughout	throughout	ADP
amwa-224	29	133	both	both	CCONJ
amwa-224	29	134	heavy	heavy	ADJ
amwa-224	29	135	and	and	CCONJ
amwa-224	29	136	light	light	ADJ
amwa-224	29	137	chain	chain	NOUN
amwa-224	29	138	regions	region	NOUN
amwa-224	29	139	of	of	ADP
amwa-224	29	140	the	the	DET
amwa-224	29	141	antibody	antibody	NOUN
amwa-224	29	142	,	,	PUNCT
amwa-224	29	143	coupling	couple	VERB
amwa-224	29	144	reactions	reaction	NOUN
amwa-224	29	145	resulting	result	VERB
amwa-224	29	146	in	in	ADP
amwa-224	29	147	payload	payload	ADJ
amwa-224	29	148	conjugation	conjugation	NOUN
amwa-224	29	149	near	near	ADP
amwa-224	29	150	antibody	antibody	NOUN
amwa-224	29	151	–	–	PUNCT
amwa-224	29	152	antigen	antigen	NOUN
amwa-224	29	153	recognition	recognition	NOUN
amwa-224	29	154	sites	site	NOUN
amwa-224	29	155	could	could	AUX
amwa-224	29	156	interfere	interfere	VERB
amwa-224	29	157	with	with	ADP
amwa-224	29	158	adc	adc	PROPN
amwa-224	29	159	target	target	NOUN
amwa-224	29	160	binding.1,39	binding.1,39	NOUN
amwa-224	29	161	moreover	moreover	ADV
amwa-224	29	162	,	,	PUNCT
amwa-224	29	163	adcs	adcs	ADJ
amwa-224	29	164	with	with	ADP
amwa-224	29	165	cytotoxic	cytotoxic	ADJ
amwa-224	29	166	payloads	payload	NOUN
amwa-224	29	167	conjugated	conjugate	VERB
amwa-224	29	168	to	to	ADP
amwa-224	29	169	heavy	heavy	ADJ
amwa-224	29	170	chain	chain	NOUN
amwa-224	29	171	regions	region	NOUN
amwa-224	29	172	of	of	ADP
amwa-224	29	173	the	the	DET
amwa-224	29	174	mab	mab	NOUN
amwa-224	29	175	have	have	VERB
amwa-224	29	176	lower	low	ADJ
amwa-224	29	177	in	in	ADP
amwa-224	29	178	vivo	vivo	ADJ
amwa-224	29	179	efficacy	efficacy	NOUN
amwa-224	29	180	compared	compare	VERB
amwa-224	29	181	with	with	ADP
amwa-224	29	182	light	light	ADJ
amwa-224	29	183	chain	chain	NOUN
amwa-224	29	184	conjugates.24,44	conjugates.24,44	VERB
amwa-224	29	185	consequently	consequently	ADV
amwa-224	29	186	,	,	PUNCT
amwa-224	29	187	novel	novel	ADJ
amwa-224	29	188	site	site	NOUN
amwa-224	29	189	-	-	PUNCT
amwa-224	29	190	specific	specific	ADJ
amwa-224	29	191	conjugation	conjugation	NOUN
amwa-224	29	192	strategies	strategy	NOUN
amwa-224	29	193	have	have	AUX
amwa-224	29	194	been	be	AUX
amwa-224	29	195	developed	develop	VERB
amwa-224	29	196	that	that	PRON
amwa-224	29	197	produce	produce	VERB
amwa-224	29	198	more	more	ADV
amwa-224	29	199	homogeneous	homogeneous	ADJ
amwa-224	29	200	adc	adc	NOUN
amwa-224	29	201	products	product	NOUN
amwa-224	29	202	with	with	ADP
amwa-224	29	203	favorable	favorable	ADJ
amwa-224	29	204	pharmacokinetic	pharmacokinetic	ADJ
amwa-224	29	205	and	and	CCONJ
amwa-224	29	206	antigen	antigen	ADJ
amwa-224	29	207	binding	bind	VERB
amwa-224	29	208	properties.1,37,41	properties.1,37,41	PROPN
amwa-224	29	209	method	method	NOUN
amwa-224	29	210	of	of	ADP
amwa-224	29	211	conjugation	conjugation	NOUN
amwa-224	29	212	:	:	PUNCT
amwa-224	29	213	site	site	NOUN
amwa-224	29	214	-	-	PUNCT
amwa-224	29	215	specific	specific	ADJ
amwa-224	29	216	site	site	NOUN
amwa-224	29	217	-	-	PUNCT
amwa-224	29	218	specific	specific	ADJ
amwa-224	29	219	conjugation	conjugation	NOUN
amwa-224	29	220	strategies	strategy	NOUN
amwa-224	29	221	are	be	AUX
amwa-224	29	222	categorized	categorize	VERB
amwa-224	29	223	according	accord	VERB
amwa-224	29	224	to	to	ADP
amwa-224	29	225	their	their	PRON
amwa-224	29	226	associated	associated	ADJ
amwa-224	29	227	methodology	methodology	NOUN
amwa-224	29	228	and	and	CCONJ
amwa-224	29	229	generally	generally	ADV
amwa-224	29	230	include	include	VERB
amwa-224	29	231	the	the	DET
amwa-224	29	232	following	follow	VERB
amwa-224	29	233	:	:	PUNCT
amwa-224	29	234	(	(	PUNCT
amwa-224	29	235	1	1	X
amwa-224	29	236	)	)	PUNCT
amwa-224	29	237	engineered	engineer	VERB
amwa-224	29	238	cysteine	cysteine	NOUN
amwa-224	29	239	residues	residue	NOUN
amwa-224	29	240	,	,	PUNCT
amwa-224	29	241	(	(	PUNCT
amwa-224	29	242	2	2	X
amwa-224	29	243	)	)	PUNCT
amwa-224	29	244	disulfide	disulfide	NOUN
amwa-224	29	245	rebridging	rebridging	NOUN
amwa-224	29	246	,	,	PUNCT
amwa-224	29	247	(	(	PUNCT
amwa-224	29	248	3	3	X
amwa-224	29	249	)	)	PUNCT
amwa-224	29	250	engineered	engineer	VERB
amwa-224	29	251	unnatural	unnatural	ADJ
amwa-224	29	252	amino	amino	NOUN
amwa-224	29	253	acids	acid	NOUN
amwa-224	29	254	,	,	PUNCT
amwa-224	29	255	(	(	PUNCT
amwa-224	29	256	4	4	X
amwa-224	29	257	)	)	PUNCT
amwa-224	29	258	enzymatic	enzymatic	ADJ
amwa-224	29	259	assisted	assist	VERB
amwa-224	29	260	ligation	ligation	NOUN
amwa-224	29	261	(	(	PUNCT
amwa-224	29	262	5	5	NUM
amwa-224	29	263	)	)	PUNCT
amwa-224	29	264	glycan	glycan	NOUN
amwa-224	29	265	remodeling	remodeling	NOUN
amwa-224	29	266	/	/	SYM
amwa-224	29	267	glycoconjugation	glycoconjugation	NOUN
amwa-224	29	268	,	,	PUNCT
amwa-224	29	269	and	and	CCONJ
amwa-224	29	270	(	(	PUNCT
amwa-224	29	271	6	6	NUM
amwa-224	29	272	)	)	PUNCT
amwa-224	29	273	proximity	proximity	NOUN
amwa-224	29	274	-	-	PUNCT
amwa-224	29	275	induced	induce	VERB
amwa-224	29	276	antibody	antibody	NOUN
amwa-224	29	277	conjugation	conjugation	NOUN
amwa-224	29	278	method	method	NOUN
amwa-224	29	279	(	(	PUNCT
amwa-224	29	280	pclick	pclick	NOUN
amwa-224	29	281	)	)	PUNCT
amwa-224	29	282	technology.1,21,45,46	technology.1,21,45,46	PROPN
amwa-224	29	283	site	site	NOUN
amwa-224	29	284	-	-	PUNCT
amwa-224	29	285	specific	specific	ADJ
amwa-224	29	286	cysteine	cysteine	NOUN
amwa-224	29	287	residues	residue	NOUN
amwa-224	29	288	are	be	AUX
amwa-224	29	289	commonly	commonly	ADV
amwa-224	29	290	engineered	engineer	VERB
amwa-224	29	291	using	use	VERB
amwa-224	29	292	thiomab	thiomab	NOUN
amwa-224	29	293	technology	technology	NOUN
amwa-224	29	294	,	,	PUNCT
amwa-224	29	295	which	which	PRON
amwa-224	29	296	allows	allow	VERB
amwa-224	29	297	specific	specific	ADJ
amwa-224	29	298	positioning	positioning	NOUN
amwa-224	29	299	of	of	ADP
amwa-224	29	300	conjugation	conjugation	NOUN
amwa-224	29	301	sites	site	NOUN
amwa-224	29	302	within	within	ADP
amwa-224	29	303	both	both	CCONJ
amwa-224	29	304	heavy	heavy	ADJ
amwa-224	29	305	chain	chain	NOUN
amwa-224	29	306	and	and	CCONJ
amwa-224	29	307	light	light	ADJ
amwa-224	29	308	chain	chain	NOUN
amwa-224	29	309	regions	region	NOUN
amwa-224	29	310	of	of	ADP
amwa-224	29	311	the	the	DET
amwa-224	29	312	antibody.47	antibody.47	PROPN
amwa-224	29	313	drug	drug	NOUN
amwa-224	29	314	conjugates	conjugate	NOUN
amwa-224	29	315	created	create	VERB
amwa-224	29	316	using	use	VERB
amwa-224	29	317	thiomab	thiomab	NOUN
amwa-224	29	318	technology	technology	NOUN
amwa-224	29	319	are	be	AUX
amwa-224	29	320	typically	typically	ADV
amwa-224	29	321	referred	refer	VERB
amwa-224	29	322	to	to	ADP
amwa-224	29	323	as	as	ADP
amwa-224	29	324	thiomab	thiomab	NOUN
amwa-224	29	325	-	-	PUNCT
amwa-224	29	326	drug	drug	NOUN
amwa-224	29	327	conjugates	conjugate	NOUN
amwa-224	29	328	and	and	CCONJ
amwa-224	29	329	are	be	AUX
amwa-224	29	330	shown	show	VERB
amwa-224	29	331	to	to	PART
amwa-224	29	332	have	have	AUX
amwa-224	29	333	improved	improve	VERB
amwa-224	29	334	safety	safety	NOUN
amwa-224	29	335	and	and	CCONJ
amwa-224	29	336	therapeutic	therapeutic	ADJ
amwa-224	29	337	indexes.46	indexes.46	PROPN
amwa-224	29	338	disulfide	disulfide	NOUN
amwa-224	29	339	rebridging	rebridging	NOUN
amwa-224	29	340	is	be	AUX
amwa-224	29	341	a	a	DET
amwa-224	29	342	process	process	NOUN
amwa-224	29	343	in	in	ADP
amwa-224	29	344	which	which	PRON
amwa-224	29	345	4	4	NUM
amwa-224	29	346	interchain	interchain	ADJ
amwa-224	29	347	disulfide	disulfide	NOUN
amwa-224	29	348	bonds	bond	NOUN
amwa-224	29	349	in	in	ADP
amwa-224	29	350	an	an	DET
amwa-224	29	351	igg	igg	NOUN
amwa-224	29	352	antibody	antibody	NOUN
amwa-224	29	353	are	be	AUX
amwa-224	29	354	reduced	reduce	VERB
amwa-224	29	355	and	and	CCONJ
amwa-224	29	356	subsequently	subsequently	ADV
amwa-224	29	357	treated	treat	VERB
amwa-224	29	358	with	with	ADP
amwa-224	29	359	a	a	DET
amwa-224	29	360	cysteine	cysteine	ADJ
amwa-224	29	361	-	-	PUNCT
amwa-224	29	362	selective	selective	ADJ
amwa-224	29	363	cross	cross	NOUN
amwa-224	29	364	-	-	ADJ
amwa-224	29	365	linking	link	VERB
amwa-224	29	366	reagent.48	reagent.48	VERB
amwa-224	29	367	this	this	DET
amwa-224	29	368	rebridging	rebridge	VERB
amwa-224	29	369	process	process	NOUN
amwa-224	29	370	enables	enable	VERB
amwa-224	29	371	simultaneous	simultaneous	ADJ
amwa-224	29	372	reattachment	reattachment	NOUN
amwa-224	29	373	of	of	ADP
amwa-224	29	374	polypeptide	polypeptide	ADJ
amwa-224	29	375	chain	chain	NOUN
amwa-224	29	376	and	and	CCONJ
amwa-224	29	377	installation	installation	NOUN
amwa-224	29	378	of	of	ADP
amwa-224	29	379	drug	drug	NOUN
amwa-224	29	380	molecules	molecule	NOUN
amwa-224	29	381	or	or	CCONJ
amwa-224	29	382	function	function	NOUN
amwa-224	29	383	groups	group	NOUN
amwa-224	29	384	that	that	PRON
amwa-224	29	385	may	may	AUX
amwa-224	29	386	be	be	AUX
amwa-224	29	387	further	far	ADV
amwa-224	29	388	modified	modify	VERB
amwa-224	29	389	.	.	PUNCT
amwa-224	30	1	genetically	genetically	ADV
amwa-224	30	2	encoded	encode	VERB
amwa-224	30	3	unnatural	unnatural	ADJ
amwa-224	30	4	amino	amino	NOUN
amwa-224	30	5	acids	acid	NOUN
amwa-224	30	6	,	,	PUNCT
amwa-224	30	7	such	such	ADJ
amwa-224	30	8	as	as	ADP
amwa-224	30	9	p	p	NOUN
amwa-224	30	10	-	-	PUNCT
amwa-224	30	11	acetylphenylalanine	acetylphenylalanine	NOUN
amwa-224	30	12	and	and	CCONJ
amwa-224	30	13	p	p	NOUN
amwa-224	30	14	-	-	PUNCT
amwa-224	30	15	azidophenylalanine	azidophenylalanine	NOUN
amwa-224	30	16	,	,	PUNCT
amwa-224	30	17	are	be	AUX
amwa-224	30	18	other	other	ADJ
amwa-224	30	19	site	site	NOUN
amwa-224	30	20	-	-	PUNCT
amwa-224	30	21	specific	specific	ADJ
amwa-224	30	22	conjugation	conjugation	NOUN
amwa-224	30	23	methods	method	NOUN
amwa-224	30	24	that	that	PRON
amwa-224	30	25	have	have	AUX
amwa-224	30	26	demonstrated	demonstrate	VERB
amwa-224	30	27	specific	specific	ADJ
amwa-224	30	28	advantages	advantage	NOUN
amwa-224	30	29	in	in	ADP
amwa-224	30	30	terms	term	NOUN
amwa-224	30	31	of	of	ADP
amwa-224	30	32	optimizing	optimize	VERB
amwa-224	30	33	physical	physical	ADJ
amwa-224	30	34	properties	property	NOUN
amwa-224	30	35	of	of	ADP
amwa-224	30	36	the	the	DET
amwa-224	30	37	adc	adc	PROPN
amwa-224	30	38	,	,	PUNCT
amwa-224	30	39	and	and	CCONJ
amwa-224	30	40	improved	improve	VERB
amwa-224	30	41	associated	associated	ADJ
amwa-224	30	42	efficacy	efficacy	NOUN
amwa-224	30	43	,	,	PUNCT
amwa-224	30	44	pharmacokinetic	pharmacokinetic	NOUN
amwa-224	30	45	,	,	PUNCT
amwa-224	30	46	and	and	CCONJ
amwa-224	30	47	safety	safety	NOUN
amwa-224	30	48	profiles.41,49	profiles.41,49	NOUN
amwa-224	30	49	compared	compare	VERB
amwa-224	30	50	with	with	ADP
amwa-224	30	51	conventional	conventional	ADJ
amwa-224	30	52	cysteine	cysteine	NOUN
amwa-224	30	53	conjugated	conjugate	VERB
amwa-224	30	54	adcs	adcs	PROPN
amwa-224	30	55	,	,	PUNCT
amwa-224	30	56	those	those	PRON
amwa-224	30	57	using	use	VERB
amwa-224	30	58	unnatural	unnatural	ADJ
amwa-224	30	59	amino	amino	ADJ
amwa-224	30	60	acids	acid	NOUN
amwa-224	30	61	for	for	ADP
amwa-224	30	62	site	site	NOUN
amwa-224	30	63	-	-	PUNCT
amwa-224	30	64	specific	specific	ADJ
amwa-224	30	65	conjugation	conjugation	NOUN
amwa-224	30	66	demonstrate	demonstrate	VERB
amwa-224	30	67	superior	superior	ADJ
amwa-224	30	68	in	in	ADP
amwa-224	30	69	vitro	vitro	X
amwa-224	30	70	selectivity	selectivity	NOUN
amwa-224	30	71	and	and	CCONJ
amwa-224	30	72	efficacy	efficacy	NOUN
amwa-224	30	73	,	,	PUNCT
amwa-224	30	74	particularly	particularly	ADV
amwa-224	30	75	in	in	ADP
amwa-224	30	76	low	low	ADJ
amwa-224	30	77	antigen	antigen	NOUN
amwa-224	30	78	expressing	express	VERB
amwa-224	30	79	tumor	tumor	NOUN
amwa-224	30	80	cells.50	cells.50	VERB
amwa-224	30	81	enzyme	enzyme	NOUN
amwa-224	30	82	-	-	PUNCT
amwa-224	30	83	assisted	assist	VERB
amwa-224	30	84	ligation	ligation	NOUN
amwa-224	30	85	techniques	technique	NOUN
amwa-224	30	86	use	use	VERB
amwa-224	30	87	enzymes	enzyme	NOUN
amwa-224	30	88	such	such	ADJ
amwa-224	30	89	as	as	ADP
amwa-224	30	90	transglutaminase	transglutaminase	NOUN
amwa-224	30	91	to	to	PART
amwa-224	30	92	conjugate	conjugate	VERB
amwa-224	30	93	specific	specific	ADJ
amwa-224	30	94	amino	amino	NOUN
amwa-224	30	95	acid	acid	NOUN
amwa-224	30	96	sequences	sequence	NOUN
amwa-224	30	97	or	or	CCONJ
amwa-224	30	98	tags	tag	NOUN
amwa-224	30	99	that	that	PRON
amwa-224	30	100	are	be	AUX
amwa-224	30	101	genetically	genetically	ADV
amwa-224	30	102	engineered	engineer	VERB
amwa-224	30	103	and	and	CCONJ
amwa-224	30	104	artificially	artificially	ADV
amwa-224	30	105	induced	induce	VERB
amwa-224	30	106	to	to	PART
amwa-224	30	107	express	express	VERB
amwa-224	30	108	in	in	ADP
amwa-224	30	109	the	the	DET
amwa-224	30	110	antibody.1,21,51	antibody.1,21,51	ADJ
amwa-224	30	111	glycan	glycan	NOUN
amwa-224	30	112	remodeling	remodeling	NOUN
amwa-224	30	113	or	or	CCONJ
amwa-224	30	114	glycoconjugahttp://www.amwajournal.org	glycoconjugahttp://www.amwajournal.org	X
amwa-224	30	115	amwajournal.org	amwajournal.org	X
amwa-224	30	116	31antibody	31antibody	NUM
amwa-224	30	117	-	-	PUNCT
amwa-224	30	118	drug	drug	NOUN
amwa-224	30	119	conjugates	conjugate	NOUN
amwa-224	30	120	tion	tion	NOUN
amwa-224	30	121	methods	method	NOUN
amwa-224	30	122	exploit	exploit	VERB
amwa-224	30	123	naturally	naturally	ADV
amwa-224	30	124	-	-	PUNCT
amwa-224	30	125	occurring	occur	VERB
amwa-224	30	126	glycosylation	glycosylation	NOUN
amwa-224	30	127	sites	site	NOUN
amwa-224	30	128	at	at	ADP
amwa-224	30	129	the	the	DET
amwa-224	30	130	n297	n297	PROPN
amwa-224	30	131	residue	residue	NOUN
amwa-224	30	132	in	in	ADP
amwa-224	30	133	the	the	DET
amwa-224	30	134	ch2	ch2	NOUN
amwa-224	30	135	domain	domain	NOUN
amwa-224	30	136	of	of	ADP
amwa-224	30	137	igg	igg	PROPN
amwa-224	30	138	antibodies.52	antibodies.52	PROPN
amwa-224	30	139	however	however	ADV
amwa-224	30	140	,	,	PUNCT
amwa-224	30	141	relative	relative	ADJ
amwa-224	30	142	to	to	ADP
amwa-224	30	143	other	other	ADJ
amwa-224	30	144	site	site	NOUN
amwa-224	30	145	-	-	PUNCT
amwa-224	30	146	specific	specific	ADJ
amwa-224	30	147	conjugation	conjugation	NOUN
amwa-224	30	148	approaches	approach	NOUN
amwa-224	30	149	,	,	PUNCT
amwa-224	30	150	glycan	glycan	NOUN
amwa-224	30	151	remodeling	remodeling	NOUN
amwa-224	30	152	has	have	AUX
amwa-224	30	153	limited	limit	VERB
amwa-224	30	154	control	control	NOUN
amwa-224	30	155	over	over	ADP
amwa-224	30	156	site	site	NOUN
amwa-224	30	157	placement	placement	NOUN
amwa-224	30	158	.	.	PUNCT
amwa-224	31	1	a	a	DET
amwa-224	31	2	site	site	NOUN
amwa-224	31	3	-	-	PUNCT
amwa-224	31	4	selective	selective	ADJ
amwa-224	31	5	conjugation	conjugation	NOUN
amwa-224	31	6	method	method	NOUN
amwa-224	31	7	using	use	VERB
amwa-224	31	8	pclick	pclick	NOUN
amwa-224	31	9	has	have	AUX
amwa-224	31	10	more	more	ADV
amwa-224	31	11	recently	recently	ADV
amwa-224	31	12	emerged	emerge	VERB
amwa-224	31	13	and	and	CCONJ
amwa-224	31	14	uses	use	VERB
amwa-224	31	15	a	a	DET
amwa-224	31	16	proximity	proximity	NOUN
amwa-224	31	17	activated	activate	VERB
amwa-224	31	18	crosslinker	crosslinker	NOUN
amwa-224	31	19	to	to	PART
amwa-224	31	20	covalently	covalently	ADV
amwa-224	31	21	attach	attach	VERB
amwa-224	31	22	to	to	ADP
amwa-224	31	23	a	a	DET
amwa-224	31	24	specific	specific	ADJ
amwa-224	31	25	antibody	antibody	NOUN
amwa-224	31	26	site	site	NOUN
amwa-224	31	27	,	,	PUNCT
amwa-224	31	28	which	which	PRON
amwa-224	31	29	eliminates	eliminate	VERB
amwa-224	31	30	the	the	DET
amwa-224	31	31	need	need	NOUN
amwa-224	31	32	for	for	ADP
amwa-224	31	33	additional	additional	ADJ
amwa-224	31	34	antibody	antibody	NOUN
amwa-224	31	35	engineering	engineering	NOUN
amwa-224	31	36	or	or	CCONJ
amwa-224	31	37	post	post	ADJ
amwa-224	31	38	-	-	ADJ
amwa-224	31	39	synthesis	synthesis	ADJ
amwa-224	31	40	treatments.53	treatments.53	NOUN
amwa-224	31	41	chemical	chemical	NOUN
amwa-224	31	42	linker	linker	NOUN
amwa-224	31	43	the	the	DET
amwa-224	31	44	primary	primary	ADJ
amwa-224	31	45	function	function	NOUN
amwa-224	31	46	of	of	ADP
amwa-224	31	47	chemical	chemical	ADJ
amwa-224	31	48	linkers	linker	NOUN
amwa-224	31	49	in	in	ADP
amwa-224	31	50	adc	adc	PROPN
amwa-224	31	51	design	design	NOUN
amwa-224	31	52	is	be	AUX
amwa-224	31	53	to	to	PART
amwa-224	31	54	effectively	effectively	ADV
amwa-224	31	55	bridge	bridge	VERB
amwa-224	31	56	the	the	DET
amwa-224	31	57	mab	mab	NOUN
amwa-224	31	58	to	to	ADP
amwa-224	31	59	the	the	DET
amwa-224	31	60	cytotoxic	cytotoxic	ADJ
amwa-224	31	61	drug	drug	NOUN
amwa-224	32	1	payload.1	payload.1	PROPN
amwa-224	32	2	adc	adc	PROPN
amwa-224	32	3	specificity	specificity	NOUN
amwa-224	32	4	,	,	PUNCT
amwa-224	32	5	potency	potency	NOUN
amwa-224	32	6	,	,	PUNCT
amwa-224	32	7	safety	safety	NOUN
amwa-224	32	8	,	,	PUNCT
amwa-224	32	9	and	and	CCONJ
amwa-224	32	10	overall	overall	ADJ
amwa-224	32	11	activity	activity	NOUN
amwa-224	32	12	are	be	AUX
amwa-224	32	13	greatly	greatly	ADV
amwa-224	32	14	influenced	influence	VERB
amwa-224	32	15	by	by	ADP
amwa-224	32	16	the	the	DET
amwa-224	32	17	associated	associated	ADJ
amwa-224	32	18	linker	linker	NOUN
amwa-224	32	19	chemistry.24	chemistry.24	NOUN
amwa-224	32	20	linkers	linker	NOUN
amwa-224	32	21	are	be	AUX
amwa-224	32	22	generally	generally	ADV
amwa-224	32	23	designed	design	VERB
amwa-224	32	24	to	to	PART
amwa-224	32	25	remain	remain	VERB
amwa-224	32	26	stable	stable	ADJ
amwa-224	32	27	in	in	ADP
amwa-224	32	28	circulation	circulation	NOUN
amwa-224	32	29	and	and	CCONJ
amwa-224	32	30	release	release	VERB
amwa-224	32	31	the	the	DET
amwa-224	32	32	drug	drug	NOUN
amwa-224	32	33	payload	payload	NOUN
amwa-224	32	34	once	once	SCONJ
amwa-224	32	35	the	the	DET
amwa-224	32	36	adc	adc	PROPN
amwa-224	32	37	has	have	AUX
amwa-224	32	38	reached	reach	VERB
amwa-224	32	39	the	the	DET
amwa-224	32	40	target	target	NOUN
amwa-224	32	41	tumor	tumor	NOUN
amwa-224	32	42	site.2,24	site.2,24	PROPN
amwa-224	32	43	chemical	chemical	NOUN
amwa-224	32	44	linkers	linker	NOUN
amwa-224	32	45	commonly	commonly	ADV
amwa-224	32	46	employed	employ	VERB
amwa-224	32	47	in	in	ADP
amwa-224	32	48	adc	adc	PROPN
amwa-224	32	49	design	design	NOUN
amwa-224	32	50	are	be	AUX
amwa-224	32	51	classified	classify	VERB
amwa-224	32	52	into	into	ADP
amwa-224	32	53	2	2	NUM
amwa-224	32	54	main	main	ADJ
amwa-224	32	55	categories	category	NOUN
amwa-224	32	56	:	:	PUNCT
amwa-224	32	57	cleavable	cleavable	ADJ
amwa-224	32	58	and	and	CCONJ
amwa-224	32	59	noncleavable	noncleavable	ADJ
amwa-224	32	60	linkers.1,24	linkers.1,24	NOUN
amwa-224	32	61	cleavable	cleavable	ADJ
amwa-224	32	62	linkers	linker	NOUN
amwa-224	32	63	cleavable	cleavable	ADJ
amwa-224	32	64	linkers	linker	NOUN
amwa-224	32	65	are	be	AUX
amwa-224	32	66	designed	design	VERB
amwa-224	32	67	to	to	PART
amwa-224	32	68	exploit	exploit	VERB
amwa-224	32	69	cancer	cancer	NOUN
amwa-224	32	70	-	-	PUNCT
amwa-224	32	71	specific	specific	ADJ
amwa-224	32	72	cellular	cellular	ADJ
amwa-224	32	73	conditions	condition	NOUN
amwa-224	32	74	and	and	CCONJ
amwa-224	32	75	are	be	AUX
amwa-224	32	76	generally	generally	ADV
amwa-224	32	77	divided	divide	VERB
amwa-224	32	78	into	into	ADP
amwa-224	32	79	3	3	NUM
amwa-224	32	80	primary	primary	ADJ
amwa-224	32	81	categories	category	NOUN
amwa-224	32	82	:	:	PUNCT
amwa-224	32	83	acid	acid	ADJ
amwa-224	32	84	or	or	CCONJ
amwa-224	32	85	ph	ph	ADJ
amwa-224	32	86	sensitive	sensitive	ADJ
amwa-224	32	87	,	,	PUNCT
amwa-224	32	88	glutathione	glutathione	NOUN
amwa-224	32	89	or	or	CCONJ
amwa-224	32	90	redox	redox	NOUN
amwa-224	32	91	sensitive	sensitive	ADJ
amwa-224	32	92	,	,	PUNCT
amwa-224	32	93	and	and	CCONJ
amwa-224	32	94	enzymatically	enzymatically	ADV
amwa-224	32	95	cleavable	cleavable	ADJ
amwa-224	32	96	(	(	PUNCT
amwa-224	32	97	eg	eg	NOUN
amwa-224	32	98	,	,	PUNCT
amwa-224	32	99	protease	protease	NOUN
amwa-224	32	100	sensitive).21,24,28	sensitive).21,24,28	PUNCT
amwa-224	32	101	acid	acid	NOUN
amwa-224	32	102	-	-	PUNCT
amwa-224	32	103	sensitive	sensitive	ADJ
amwa-224	32	104	linkers	linker	NOUN
amwa-224	32	105	,	,	PUNCT
amwa-224	32	106	such	such	ADJ
amwa-224	32	107	as	as	ADP
amwa-224	32	108	hydrazone	hydrazone	NOUN
amwa-224	32	109	,	,	PUNCT
amwa-224	32	110	are	be	AUX
amwa-224	32	111	designed	design	VERB
amwa-224	32	112	to	to	PART
amwa-224	32	113	release	release	VERB
amwa-224	32	114	the	the	DET
amwa-224	32	115	drug	drug	NOUN
amwa-224	32	116	payload	payload	NOUN
amwa-224	32	117	within	within	ADP
amwa-224	32	118	acidic	acidic	ADJ
amwa-224	32	119	environments	environment	NOUN
amwa-224	32	120	,	,	PUNCT
amwa-224	32	121	such	such	ADJ
amwa-224	32	122	as	as	ADP
amwa-224	32	123	lysosomal	lysosomal	ADJ
amwa-224	32	124	or	or	CCONJ
amwa-224	32	125	endosomal	endosomal	ADJ
amwa-224	32	126	cellular	cellular	ADJ
amwa-224	32	127	compartments	compartment	NOUN
amwa-224	32	128	,	,	PUNCT
amwa-224	32	129	while	while	SCONJ
amwa-224	32	130	remaining	remain	VERB
amwa-224	32	131	stable	stable	ADJ
amwa-224	32	132	within	within	ADP
amwa-224	32	133	the	the	DET
amwa-224	32	134	blood	blood	NOUN
amwa-224	32	135	’s	’s	PART
amwa-224	32	136	neutral	neutral	ADJ
amwa-224	32	137	ph	ph	ADJ
amwa-224	32	138	environment.1,31	environment.1,31	PROPN
amwa-224	32	139	glutathione	glutathione	NOUN
amwa-224	32	140	-	-	PUNCT
amwa-224	32	141	sensitive	sensitive	ADJ
amwa-224	32	142	or	or	CCONJ
amwa-224	32	143	disulfide	disulfide	NOUN
amwa-224	32	144	linkers	linker	NOUN
amwa-224	32	145	exploit	exploit	VERB
amwa-224	32	146	the	the	DET
amwa-224	32	147	high	high	ADJ
amwa-224	32	148	levels	level	NOUN
amwa-224	32	149	of	of	ADP
amwa-224	32	150	glutathione	glutathione	NOUN
amwa-224	32	151	and	and	CCONJ
amwa-224	32	152	other	other	ADJ
amwa-224	32	153	thiols	thiol	NOUN
amwa-224	32	154	present	present	ADJ
amwa-224	32	155	in	in	ADP
amwa-224	32	156	the	the	DET
amwa-224	32	157	cytosol	cytosol	NOUN
amwa-224	32	158	of	of	ADP
amwa-224	32	159	cancer	cancer	NOUN
amwa-224	32	160	cells	cell	NOUN
amwa-224	32	161	,	,	PUNCT
amwa-224	32	162	thereby	thereby	ADV
amwa-224	32	163	enabling	enable	VERB
amwa-224	32	164	selective	selective	ADJ
amwa-224	32	165	cleavage	cleavage	NOUN
amwa-224	32	166	of	of	ADP
amwa-224	32	167	the	the	DET
amwa-224	32	168	cytotoxic	cytotoxic	ADJ
amwa-224	32	169	payload	payload	NOUN
amwa-224	32	170	at	at	ADP
amwa-224	32	171	the	the	DET
amwa-224	32	172	tumor	tumor	NOUN
amwa-224	32	173	site.24,28,54	site.24,28,54	ADP
amwa-224	32	174	protease	protease	NOUN
amwa-224	32	175	sensitive	sensitive	ADJ
amwa-224	32	176	or	or	CCONJ
amwa-224	32	177	peptide	peptide	NOUN
amwa-224	32	178	-	-	PUNCT
amwa-224	32	179	based	base	VERB
amwa-224	32	180	linkers	linker	NOUN
amwa-224	32	181	most	most	ADV
amwa-224	32	182	often	often	ADV
amwa-224	32	183	consist	consist	VERB
amwa-224	32	184	of	of	ADP
amwa-224	32	185	dipeptide	dipeptide	NOUN
amwa-224	32	186	linkers	linker	NOUN
amwa-224	32	187	(	(	PUNCT
amwa-224	32	188	eg	eg	NOUN
amwa-224	32	189	,	,	PUNCT
amwa-224	32	190	valine	valine	NOUN
amwa-224	32	191	-	-	PUNCT
amwa-224	32	192	citrulline	citrulline	NOUN
amwa-224	32	193	)	)	PUNCT
amwa-224	32	194	,	,	PUNCT
amwa-224	32	195	which	which	PRON
amwa-224	32	196	require	require	VERB
amwa-224	32	197	enzymatic	enzymatic	ADJ
amwa-224	32	198	cleavage	cleavage	NOUN
amwa-224	32	199	of	of	ADP
amwa-224	32	200	peptide	peptide	ADJ
amwa-224	32	201	bonds	bond	NOUN
amwa-224	32	202	for	for	ADP
amwa-224	32	203	payload	payload	NOUN
amwa-224	33	1	release.28,31,55	release.28,31,55	PROPN
amwa-224	33	2	compared	compare	VERB
amwa-224	33	3	with	with	ADP
amwa-224	33	4	chemically	chemically	ADV
amwa-224	33	5	liable	liable	ADJ
amwa-224	33	6	linkers	linker	NOUN
amwa-224	33	7	(	(	PUNCT
amwa-224	33	8	eg	eg	NOUN
amwa-224	33	9	,	,	PUNCT
amwa-224	33	10	hydrazone	hydrazone	NOUN
amwa-224	33	11	and	and	CCONJ
amwa-224	33	12	disulfide	disulfide	NOUN
amwa-224	33	13	)	)	PUNCT
amwa-224	33	14	,	,	PUNCT
amwa-224	33	15	peptide	peptide	NOUN
amwa-224	33	16	-	-	PUNCT
amwa-224	33	17	based	base	VERB
amwa-224	33	18	linker	linker	NOUN
amwa-224	33	19	technologies	technology	NOUN
amwa-224	33	20	allow	allow	VERB
amwa-224	33	21	for	for	ADP
amwa-224	33	22	greater	great	ADJ
amwa-224	33	23	control	control	NOUN
amwa-224	33	24	of	of	ADP
amwa-224	33	25	drug	drug	NOUN
amwa-224	33	26	delivery	delivery	NOUN
amwa-224	33	27	,	,	PUNCT
amwa-224	33	28	with	with	ADP
amwa-224	33	29	improved	improve	VERB
amwa-224	33	30	systemic	systemic	ADJ
amwa-224	33	31	stability	stability	NOUN
amwa-224	33	32	and	and	CCONJ
amwa-224	33	33	rapid	rapid	ADJ
amwa-224	33	34	enzyme	enzyme	NOUN
amwa-224	33	35	-	-	PUNCT
amwa-224	33	36	mediated	mediate	VERB
amwa-224	33	37	release	release	NOUN
amwa-224	33	38	of	of	ADP
amwa-224	33	39	the	the	DET
amwa-224	33	40	drug	drug	NOUN
amwa-224	33	41	payload	payload	NOUN
amwa-224	33	42	within	within	ADP
amwa-224	33	43	the	the	DET
amwa-224	33	44	target	target	NOUN
amwa-224	33	45	cell.31	cell.31	NOUN
amwa-224	33	46	noncleavable	noncleavable	ADJ
amwa-224	33	47	linkers	linker	NOUN
amwa-224	33	48	in	in	ADP
amwa-224	33	49	contrast	contrast	NOUN
amwa-224	33	50	with	with	ADP
amwa-224	33	51	cleavable	cleavable	ADJ
amwa-224	33	52	linkers	linker	NOUN
amwa-224	33	53	that	that	PRON
amwa-224	33	54	rely	rely	VERB
amwa-224	33	55	on	on	ADP
amwa-224	33	56	tumor	tumor	NOUN
amwa-224	33	57	-	-	PUNCT
amwa-224	33	58	specific	specific	ADJ
amwa-224	33	59	cellular	cellular	ADJ
amwa-224	33	60	conditions	condition	NOUN
amwa-224	33	61	for	for	ADP
amwa-224	33	62	payload	payload	NOUN
amwa-224	33	63	release	release	NOUN
amwa-224	33	64	,	,	PUNCT
amwa-224	33	65	noncleavable	noncleavable	ADJ
amwa-224	33	66	linkers	linker	NOUN
amwa-224	33	67	require	require	VERB
amwa-224	33	68	internalization	internalization	NOUN
amwa-224	33	69	via	via	ADP
amwa-224	33	70	antigen	antigen	ADV
amwa-224	33	71	-	-	PUNCT
amwa-224	33	72	mediated	mediate	VERB
amwa-224	33	73	endocytosis	endocytosis	NOUN
amwa-224	33	74	and	and	CCONJ
amwa-224	33	75	lysosome	lysosome	NOUN
amwa-224	33	76	-	-	PUNCT
amwa-224	33	77	mediated	mediate	VERB
amwa-224	33	78	proteolytic	proteolytic	ADJ
amwa-224	33	79	degradation	degradation	NOUN
amwa-224	33	80	for	for	ADP
amwa-224	33	81	payload	payload	ADJ
amwa-224	33	82	release.24,31,56	release.24,31,56	NOUN
amwa-224	33	83	generally	generally	ADV
amwa-224	33	84	,	,	PUNCT
amwa-224	33	85	noncleavable	noncleavable	ADJ
amwa-224	33	86	linkers	linker	NOUN
amwa-224	33	87	are	be	AUX
amwa-224	33	88	associated	associate	VERB
amwa-224	33	89	with	with	ADP
amwa-224	33	90	greater	great	ADJ
amwa-224	33	91	plasma	plasma	NOUN
amwa-224	33	92	stability	stability	NOUN
amwa-224	33	93	,	,	PUNCT
amwa-224	33	94	longer	long	ADJ
amwa-224	33	95	half	half	ADJ
amwa-224	33	96	-	-	PUNCT
amwa-224	33	97	lives	life	NOUN
amwa-224	33	98	,	,	PUNCT
amwa-224	33	99	and	and	CCONJ
amwa-224	33	100	pose	pose	VERB
amwa-224	33	101	a	a	DET
amwa-224	33	102	reduced	reduced	ADJ
amwa-224	33	103	risk	risk	NOUN
amwa-224	33	104	for	for	ADP
amwa-224	33	105	off	off	ADP
amwa-224	33	106	-	-	PUNCT
amwa-224	33	107	target	target	NOUN
amwa-224	33	108	side	side	NOUN
amwa-224	33	109	effects	effect	NOUN
amwa-224	33	110	.	.	PUNCT
amwa-224	34	1	however	however	ADV
amwa-224	34	2	,	,	PUNCT
amwa-224	34	3	the	the	DET
amwa-224	34	4	actions	action	NOUN
amwa-224	34	5	of	of	ADP
amwa-224	34	6	adcs	adcs	ADJ
amwa-224	34	7	with	with	ADP
amwa-224	34	8	noncleavable	noncleavable	ADJ
amwa-224	34	9	links	link	NOUN
amwa-224	34	10	are	be	AUX
amwa-224	34	11	typically	typically	ADV
amwa-224	34	12	restricted	restrict	VERB
amwa-224	34	13	to	to	ADP
amwa-224	34	14	the	the	DET
amwa-224	34	15	target	target	NOUN
amwa-224	34	16	tumor	tumor	NOUN
amwa-224	34	17	cell	cell	NOUN
amwa-224	34	18	.	.	PUNCT
amwa-224	35	1	moreover	moreover	ADV
amwa-224	35	2	,	,	PUNCT
amwa-224	35	3	amino	amino	ADJ
amwa-224	35	4	acid	acid	NOUN
amwa-224	35	5	-	-	PUNCT
amwa-224	35	6	drug	drug	NOUN
amwa-224	35	7	metabolites	metabolite	NOUN
amwa-224	35	8	resulting	result	VERB
amwa-224	35	9	from	from	ADP
amwa-224	35	10	the	the	DET
amwa-224	35	11	drug	drug	NOUN
amwa-224	35	12	payload	payload	NOUN
amwa-224	35	13	release	release	NOUN
amwa-224	35	14	tend	tend	VERB
amwa-224	35	15	to	to	PART
amwa-224	35	16	be	be	AUX
amwa-224	35	17	more	more	ADV
amwa-224	35	18	hydrophilic	hydrophilic	ADJ
amwa-224	35	19	and	and	CCONJ
amwa-224	35	20	have	have	VERB
amwa-224	35	21	greater	great	ADJ
amwa-224	35	22	intrinsic	intrinsic	ADJ
amwa-224	35	23	polarity	polarity	NOUN
amwa-224	35	24	,	,	PUNCT
amwa-224	35	25	which	which	PRON
amwa-224	35	26	reduces	reduce	VERB
amwa-224	35	27	bystander	bystander	NOUN
amwa-224	35	28	effect	effect	NOUN
amwa-224	35	29	.	.	PUNCT
amwa-224	36	1	commonly	commonly	ADV
amwa-224	36	2	used	use	VERB
amwa-224	36	3	noncleavable	noncleavable	ADJ
amwa-224	36	4	linkers	linker	NOUN
amwa-224	36	5	in	in	ADP
amwa-224	36	6	adc	adc	PROPN
amwa-224	36	7	design	design	NOUN
amwa-224	36	8	include	include	VERB
amwa-224	36	9	the	the	DET
amwa-224	36	10	thioether	thioether	ADJ
amwa-224	36	11	linker	linker	NOUN
amwa-224	36	12	succinimidyl-4-(n	succinimidyl-4-(n	PROPN
amwa-224	36	13	-	-	PUNCT
amwa-224	36	14	maleimidomethyl	maleimidomethyl	NOUN
amwa-224	36	15	)	)	PUNCT
amwa-224	36	16	cyclohexane-1	cyclohexane-1	NOUN
amwa-224	36	17	-	-	PUNCT
amwa-224	36	18	carboxylate	carboxylate	NOUN
amwa-224	36	19	or	or	CCONJ
amwa-224	36	20	maleimide	maleimide	ADJ
amwa-224	36	21	moieties	moiety	NOUN
amwa-224	36	22	,	,	PUNCT
amwa-224	36	23	such	such	ADJ
amwa-224	36	24	as	as	ADP
amwa-224	36	25	maleimdopropionyl	maleimdopropionyl	NOUN
amwa-224	36	26	and	and	CCONJ
amwa-224	36	27	maleimdocaproyl.25	maleimdocaproyl.25	NOUN
amwa-224	36	28	cytotoxic	cytotoxic	ADJ
amwa-224	36	29	drug	drug	NOUN
amwa-224	36	30	payload	payload	NOUN
amwa-224	36	31	the	the	DET
amwa-224	36	32	drug	drug	NOUN
amwa-224	36	33	payloads	payload	NOUN
amwa-224	36	34	employed	employ	VERB
amwa-224	36	35	in	in	ADP
amwa-224	36	36	the	the	DET
amwa-224	36	37	design	design	NOUN
amwa-224	36	38	of	of	ADP
amwa-224	36	39	adcs	adc	NOUN
amwa-224	36	40	are	be	AUX
amwa-224	36	41	typically	typically	ADV
amwa-224	36	42	100	100	NUM
amwa-224	36	43	to	to	PART
amwa-224	36	44	1,000	1,000	NUM
amwa-224	36	45	times	time	NOUN
amwa-224	36	46	more	more	ADV
amwa-224	36	47	potent	potent	ADJ
amwa-224	36	48	than	than	SCONJ
amwa-224	36	49	the	the	DET
amwa-224	36	50	cytotoxic	cytotoxic	ADJ
amwa-224	36	51	agents	agent	NOUN
amwa-224	36	52	used	use	VERB
amwa-224	36	53	in	in	ADP
amwa-224	36	54	traditional	traditional	ADJ
amwa-224	36	55	chemotherapy.24,57	chemotherapy.24,57	NOUN
amwa-224	36	56	cytotoxic	cytotoxic	ADJ
amwa-224	36	57	payloads	payload	NOUN
amwa-224	36	58	are	be	AUX
amwa-224	36	59	generally	generally	ADV
amwa-224	36	60	subdivided	subdivide	VERB
amwa-224	36	61	into	into	ADP
amwa-224	36	62	2	2	NUM
amwa-224	36	63	main	main	ADJ
amwa-224	36	64	categories	category	NOUN
amwa-224	36	65	:	:	PUNCT
amwa-224	36	66	(	(	PUNCT
amwa-224	36	67	1	1	X
amwa-224	36	68	)	)	PUNCT
amwa-224	36	69	dna	dna	NOUN
amwa-224	36	70	-	-	PUNCT
amwa-224	36	71	damaging	damaging	ADJ
amwa-224	36	72	agents	agent	NOUN
amwa-224	36	73	,	,	PUNCT
amwa-224	36	74	including	include	VERB
amwa-224	36	75	calicheamicins	calicheamicin	NOUN
amwa-224	36	76	,	,	PUNCT
amwa-224	36	77	duocarmycins	duocarmycin	NOUN
amwa-224	36	78	,	,	PUNCT
amwa-224	36	79	pyrrolobenzodiazepines	pyrrolobenzodiazepine	NOUN
amwa-224	36	80	and	and	CCONJ
amwa-224	36	81	camptothecin	camptothecin	NOUN
amwa-224	36	82	analogues	analogue	NOUN
amwa-224	36	83	;	;	PUNCT
amwa-224	36	84	and	and	CCONJ
amwa-224	36	85	(	(	PUNCT
amwa-224	36	86	2	2	X
amwa-224	36	87	)	)	PUNCT
amwa-224	36	88	anti	anti	ADJ
amwa-224	36	89	-	-	ADJ
amwa-224	36	90	tubulin	tubulin	ADJ
amwa-224	36	91	agents	agent	NOUN
amwa-224	36	92	,	,	PUNCT
amwa-224	36	93	including	include	VERB
amwa-224	36	94	auristatins	auristatin	NOUN
amwa-224	36	95	,	,	PUNCT
amwa-224	36	96	maytansinoids	maytansinoid	NOUN
amwa-224	36	97	,	,	PUNCT
amwa-224	36	98	and	and	CCONJ
amwa-224	36	99	tubulysins.1,24,28	tubulysins.1,24,28	NOUN
amwa-224	36	100	calicheamicins	calicheamicin	NOUN
amwa-224	36	101	(	(	PUNCT
amwa-224	36	102	eg	eg	NOUN
amwa-224	36	103	,	,	PUNCT
amwa-224	36	104	ozogamicin	ozogamicin	PROPN
amwa-224	36	105	)	)	PUNCT
amwa-224	36	106	were	be	AUX
amwa-224	36	107	first	first	ADV
amwa-224	36	108	isolated	isolate	VERB
amwa-224	36	109	from	from	ADP
amwa-224	36	110	the	the	DET
amwa-224	36	111	actinomycete	actinomycete	ADJ
amwa-224	36	112	micromonospora	micromonospora	PROPN
amwa-224	36	113	echinospora	echinospora	PROPN
amwa-224	36	114	in	in	ADP
amwa-224	36	115	the	the	DET
amwa-224	36	116	mid1980s	mid1980	NOUN
amwa-224	36	117	,	,	PUNCT
amwa-224	36	118	and	and	CCONJ
amwa-224	36	119	act	act	VERB
amwa-224	36	120	by	by	ADP
amwa-224	36	121	binding	bind	VERB
amwa-224	36	122	the	the	DET
amwa-224	36	123	minor	minor	ADJ
amwa-224	36	124	groove	groove	NOUN
amwa-224	36	125	of	of	ADP
amwa-224	36	126	dna	dna	PROPN
amwa-224	36	127	,	,	PUNCT
amwa-224	36	128	causing	cause	VERB
amwa-224	36	129	site	site	NOUN
amwa-224	36	130	-	-	PUNCT
amwa-224	36	131	specific	specific	ADJ
amwa-224	36	132	,	,	PUNCT
amwa-224	36	133	double	double	ADJ
amwa-224	36	134	-	-	PUNCT
amwa-224	36	135	stranded	strand	VERB
amwa-224	36	136	dna	dna	PROPN
amwa-224	36	137	breaks.31,58	breaks.31,58	NOUN
amwa-224	36	138	-	-	PUNCT
amwa-224	36	139	60	60	NUM
amwa-224	36	140	notably	notably	ADV
amwa-224	36	141	,	,	PUNCT
amwa-224	36	142	calicheamicins	calicheamicin	NOUN
amwa-224	36	143	are	be	AUX
amwa-224	36	144	highly	highly	ADV
amwa-224	36	145	hydrophobic	hydrophobic	ADJ
amwa-224	36	146	,	,	PUNCT
amwa-224	36	147	which	which	PRON
amwa-224	36	148	limits	limit	VERB
amwa-224	36	149	the	the	DET
amwa-224	36	150	dar	dar	NOUN
amwa-224	36	151	or	or	CCONJ
amwa-224	36	152	number	number	NOUN
amwa-224	36	153	of	of	ADP
amwa-224	36	154	payload	payload	ADJ
amwa-224	36	155	molecules	molecule	NOUN
amwa-224	36	156	able	able	ADJ
amwa-224	36	157	to	to	PART
amwa-224	36	158	be	be	AUX
amwa-224	36	159	attached	attach	VERB
amwa-224	36	160	per	per	ADP
amwa-224	36	161	mab	mab	NOUN
amwa-224	36	162	.	.	PUNCT
amwa-224	37	1	duocarmycins	duocarmycin	NOUN
amwa-224	37	2	are	be	AUX
amwa-224	37	3	potent	potent	ADJ
amwa-224	37	4	alkylating	alkylating	NOUN
amwa-224	37	5	compounds	compound	NOUN
amwa-224	37	6	derived	derive	VERB
amwa-224	37	7	from	from	ADP
amwa-224	37	8	the	the	DET
amwa-224	37	9	bacteria	bacteria	NOUN
amwa-224	37	10	species	specie	NOUN
amwa-224	37	11	streptomyces	streptomyce	VERB
amwa-224	37	12	zelensis	zelensis	NOUN
amwa-224	37	13	.	.	PUNCT
amwa-224	38	1	duocarmycin	duocarmycin	PROPN
amwa-224	38	2	and	and	CCONJ
amwa-224	38	3	its	its	PRON
amwa-224	38	4	derivatives	derivative	NOUN
amwa-224	38	5	,	,	PUNCT
amwa-224	38	6	such	such	ADJ
amwa-224	38	7	as	as	ADP
amwa-224	38	8	duocarmazine	duocarmazine	NOUN
amwa-224	38	9	,	,	PUNCT
amwa-224	38	10	act	act	VERB
amwa-224	38	11	by	by	ADP
amwa-224	38	12	binding	bind	VERB
amwa-224	38	13	to	to	ADP
amwa-224	38	14	and	and	CCONJ
amwa-224	38	15	alkylating	alkylate	VERB
amwa-224	38	16	adenine	adenine	NOUN
amwa-224	38	17	within	within	ADP
amwa-224	38	18	the	the	DET
amwa-224	38	19	minor	minor	ADJ
amwa-224	38	20	groove	groove	NOUN
amwa-224	38	21	of	of	ADP
amwa-224	38	22	dna	dna	PROPN
amwa-224	38	23	,	,	PUNCT
amwa-224	38	24	leading	lead	VERB
amwa-224	38	25	to	to	ADP
amwa-224	38	26	subsequent	subsequent	ADJ
amwa-224	38	27	dna	dna	NOUN
amwa-224	38	28	strand	strand	NOUN
amwa-224	38	29	cleavage	cleavage	NOUN
amwa-224	38	30	and	and	CCONJ
amwa-224	38	31	cellular	cellular	ADJ
amwa-224	38	32	apoptosis.61	apoptosis.61	NOUN
amwa-224	38	33	-	-	PUNCT
amwa-224	38	34	64	64	NUM
amwa-224	38	35	pyrrolobenzodiazepine	pyrrolobenzodiazepine	NOUN
amwa-224	38	36	(	(	PUNCT
amwa-224	38	37	pbd	pbd	PROPN
amwa-224	38	38	)	)	PUNCT
amwa-224	38	39	dimers	dimer	NOUN
amwa-224	38	40	,	,	PUNCT
amwa-224	38	41	such	such	ADJ
amwa-224	38	42	as	as	ADP
amwa-224	38	43	tesirine	tesirine	NOUN
amwa-224	38	44	,	,	PUNCT
amwa-224	38	45	are	be	AUX
amwa-224	38	46	dna	dna	NOUN
amwa-224	38	47	-	-	PUNCT
amwa-224	38	48	damaging	damaging	ADJ
amwa-224	38	49	agents	agent	NOUN
amwa-224	38	50	derived	derive	VERB
amwa-224	38	51	from	from	ADP
amwa-224	38	52	anthramycin	anthramycin	PROPN
amwa-224	38	53	,	,	PUNCT
amwa-224	38	54	an	an	DET
amwa-224	38	55	antitumor	antitumor	PROPN
amwa-224	38	56	antibiotic	antibiotic	NOUN
amwa-224	38	57	isolated	isolate	VERB
amwa-224	38	58	from	from	ADP
amwa-224	38	59	streptomyces.65	streptomyces.65	NOUN
amwa-224	38	60	-	-	PUNCT
amwa-224	38	61	68	68	NUM
amwa-224	38	62	pbd	pbd	NOUN
amwa-224	38	63	dimers	dimer	NOUN
amwa-224	38	64	bind	bind	VERB
amwa-224	38	65	the	the	DET
amwa-224	38	66	dna	dna	PROPN
amwa-224	38	67	minor	minor	ADJ
amwa-224	38	68	groove	groove	NOUN
amwa-224	38	69	,	,	PUNCT
amwa-224	38	70	forming	form	VERB
amwa-224	38	71	covalent	covalent	ADJ
amwa-224	38	72	interstrand	interstrand	NOUN
amwa-224	38	73	dna	dna	NOUN
amwa-224	38	74	crosslinks	crosslink	VERB
amwa-224	38	75	within	within	ADP
amwa-224	38	76	tumor	tumor	NOUN
amwa-224	38	77	cells	cell	NOUN
amwa-224	38	78	that	that	PRON
amwa-224	38	79	lead	lead	VERB
amwa-224	38	80	to	to	ADP
amwa-224	38	81	cytotoxicity	cytotoxicity	NOUN
amwa-224	38	82	and	and	CCONJ
amwa-224	38	83	cell	cell	NOUN
amwa-224	38	84	death.28,69,70	death.28,69,70	ADP
amwa-224	38	85	the	the	DET
amwa-224	38	86	formation	formation	NOUN
amwa-224	38	87	of	of	ADP
amwa-224	38	88	crosslinks	crosslink	NOUN
amwa-224	38	89	resulting	result	VERB
amwa-224	38	90	from	from	ADP
amwa-224	38	91	pbd	pbd	NOUN
amwa-224	38	92	activity	activity	NOUN
amwa-224	38	93	,	,	PUNCT
amwa-224	38	94	which	which	PRON
amwa-224	38	95	occurs	occur	VERB
amwa-224	38	96	rapidly	rapidly	ADV
amwa-224	38	97	and	and	CCONJ
amwa-224	38	98	with	with	ADP
amwa-224	38	99	minimal	minimal	ADJ
amwa-224	38	100	dna	dna	NOUN
amwa-224	38	101	distortion	distortion	NOUN
amwa-224	38	102	,	,	PUNCT
amwa-224	38	103	is	be	AUX
amwa-224	38	104	thought	think	VERB
amwa-224	38	105	to	to	PART
amwa-224	38	106	contribute	contribute	VERB
amwa-224	38	107	to	to	ADP
amwa-224	38	108	their	their	PRON
amwa-224	38	109	persistence	persistence	NOUN
amwa-224	38	110	and	and	CCONJ
amwa-224	38	111	evasion	evasion	NOUN
amwa-224	38	112	of	of	ADP
amwa-224	38	113	dna	dna	PROPN
amwa-224	38	114	repair	repair	NOUN
amwa-224	38	115	mechanisms	mechanism	NOUN
amwa-224	38	116	.	.	PUNCT
amwa-224	39	1	campothecin	campothecin	PROPN
amwa-224	39	2	is	be	AUX
amwa-224	39	3	a	a	DET
amwa-224	39	4	pentacyclic	pentacyclic	ADJ
amwa-224	39	5	alkaloid	alkaloid	NOUN
amwa-224	39	6	isolated	isolate	VERB
amwa-224	39	7	from	from	ADP
amwa-224	39	8	the	the	DET
amwa-224	39	9	stem	stem	NOUN
amwa-224	39	10	wood	wood	NOUN
amwa-224	39	11	of	of	ADP
amwa-224	39	12	camototheca	camototheca	NOUN
amwa-224	39	13	acuminata	acuminata	NOUN
amwa-224	39	14	,	,	PUNCT
amwa-224	39	15	a	a	DET
amwa-224	39	16	tree	tree	NOUN
amwa-224	39	17	indigenous	indigenous	ADJ
amwa-224	39	18	to	to	ADP
amwa-224	39	19	china.71	china.71	VERB
amwa-224	39	20	-	-	PUNCT
amwa-224	39	21	73	73	NUM
amwa-224	39	22	campothecin	campothecin	NOUN
amwa-224	39	23	and	and	CCONJ
amwa-224	39	24	its	its	PRON
amwa-224	39	25	derivatives	derivative	NOUN
amwa-224	39	26	(	(	PUNCT
amwa-224	39	27	eg	eg	NOUN
amwa-224	39	28	,	,	PUNCT
amwa-224	39	29	govitecan	govitecan	ADJ
amwa-224	39	30	,	,	PUNCT
amwa-224	39	31	deruxtecan	deruxtecan	ADJ
amwa-224	39	32	)	)	PUNCT
amwa-224	39	33	act	act	NOUN
amwa-224	39	34	by	by	ADP
amwa-224	39	35	inhibiting	inhibit	VERB
amwa-224	39	36	topoisomerase	topoisomerase	NOUN
amwa-224	39	37	i	i	PRON
amwa-224	39	38	enzyme	enzyme	NOUN
amwa-224	39	39	activity	activity	NOUN
amwa-224	39	40	,	,	PUNCT
amwa-224	39	41	which	which	PRON
amwa-224	39	42	results	result	VERB
amwa-224	39	43	in	in	ADP
amwa-224	39	44	double	double	ADJ
amwa-224	39	45	-	-	PUNCT
amwa-224	39	46	stranded	strand	VERB
amwa-224	39	47	dna	dna	NOUN
amwa-224	39	48	breaks	break	NOUN
amwa-224	39	49	and	and	CCONJ
amwa-224	39	50	subsequent	subsequent	ADJ
amwa-224	39	51	cell	cell	NOUN
amwa-224	39	52	death.72	death.72	PROPN
amwa-224	39	53	-	-	PUNCT
amwa-224	39	54	75	75	NUM
amwa-224	39	55	auristatins	auristatin	NOUN
amwa-224	39	56	commonly	commonly	ADV
amwa-224	39	57	used	use	VERB
amwa-224	39	58	as	as	ADP
amwa-224	39	59	adc	adc	PROPN
amwa-224	39	60	payloads	payload	NOUN
amwa-224	39	61	include	include	VERB
amwa-224	39	62	monomethyl	monomethyl	ADJ
amwa-224	39	63	auristatin	auristatin	PROPN
amwa-224	39	64	e	e	NOUN
amwa-224	39	65	and	and	CCONJ
amwa-224	39	66	monomethyl	monomethyl	PROPN
amwa-224	39	67	auristatin	auristatin	PROPN
amwa-224	39	68	f	f	PROPN
amwa-224	39	69	,	,	PUNCT
amwa-224	39	70	which	which	PRON
amwa-224	39	71	are	be	AUX
amwa-224	39	72	both	both	CCONJ
amwa-224	39	73	synthetic	synthetic	ADJ
amwa-224	39	74	analogues	analogue	NOUN
amwa-224	39	75	of	of	ADP
amwa-224	39	76	dolastatin	dolastatin	NOUN
amwa-224	39	77	10	10	NUM
amwa-224	39	78	,	,	PUNCT
amwa-224	39	79	a	a	DET
amwa-224	39	80	naturally	naturally	ADV
amwa-224	39	81	-	-	PUNCT
amwa-224	39	82	occurring	occur	VERB
amwa-224	39	83	antimitotic	antimitotic	ADJ
amwa-224	39	84	drug	drug	NOUN
amwa-224	39	85	isolated	isolate	VERB
amwa-224	39	86	from	from	ADP
amwa-224	39	87	the	the	DET
amwa-224	39	88	sea	sea	NOUN
amwa-224	39	89	hare	hare	NOUN
amwa-224	39	90	dolabella	dolabella	PROPN
amwa-224	39	91	auricularia.28,76,77	auricularia.28,76,77	NOUN
amwa-224	39	92	auristatins	auristatin	VERB
amwa-224	39	93	inhibit	inhibit	VERB
amwa-224	39	94	tubulin	tubulin	NOUN
amwa-224	39	95	polymerization	polymerization	NOUN
amwa-224	39	96	by	by	ADP
amwa-224	39	97	attaching	attach	VERB
amwa-224	39	98	to	to	ADP
amwa-224	39	99	the	the	DET
amwa-224	39	100	same	same	ADJ
amwa-224	39	101	binding	bind	VERB
amwa-224	39	102	site	site	NOUN
amwa-224	39	103	as	as	ADP
amwa-224	39	104	vinca	vinca	NOUN
amwa-224	39	105	alkahttp://www.amwajournal.org	alkahttp://www.amwajournal.org	X
amwa-224	39	106	amwajournal.org	amwajournal.org	X
amwa-224	39	107	32antibody	32antibody	NUM
amwa-224	39	108	-	-	PUNCT
amwa-224	39	109	drug	drug	NOUN
amwa-224	39	110	conjugates	conjugate	NOUN
amwa-224	39	111	loids	loid	VERB
amwa-224	39	112	(	(	PUNCT
amwa-224	39	113	eg	eg	NOUN
amwa-224	39	114	,	,	PUNCT
amwa-224	39	115	vincristine	vincristine	NOUN
amwa-224	39	116	,	,	PUNCT
amwa-224	39	117	vinblastine	vinblastine	NOUN
amwa-224	39	118	)	)	PUNCT
amwa-224	39	119	,	,	PUNCT
amwa-224	39	120	which	which	PRON
amwa-224	39	121	are	be	AUX
amwa-224	39	122	frequently	frequently	ADV
amwa-224	39	123	used	use	VERB
amwa-224	39	124	as	as	ADP
amwa-224	39	125	traditional	traditional	ADJ
amwa-224	39	126	chemotherapy	chemotherapy	NOUN
amwa-224	39	127	agents.78	agents.78	PROPN
amwa-224	39	128	-	-	PUNCT
amwa-224	39	129	80	80	NUM
amwa-224	39	130	maytansinoids	maytansinoid	NOUN
amwa-224	39	131	are	be	AUX
amwa-224	39	132	benzoansamacrolides	benzoansamacrolide	NOUN
amwa-224	39	133	derived	derive	VERB
amwa-224	39	134	from	from	ADP
amwa-224	39	135	the	the	DET
amwa-224	39	136	bark	bark	NOUN
amwa-224	39	137	of	of	ADP
amwa-224	39	138	an	an	DET
amwa-224	39	139	african	african	ADJ
amwa-224	39	140	shrub	shrub	NOUN
amwa-224	39	141	,	,	PUNCT
amwa-224	40	1	maytenus	maytenus	INTJ
amwa-224	40	2	ovatus.81	ovatus.81	NOUN
amwa-224	40	3	similar	similar	ADJ
amwa-224	40	4	to	to	ADP
amwa-224	40	5	auristatins	auristatin	NOUN
amwa-224	40	6	,	,	PUNCT
amwa-224	40	7	maytansinoids	maytansinoid	NOUN
amwa-224	40	8	bind	bind	VERB
amwa-224	40	9	at	at	ADP
amwa-224	40	10	or	or	CCONJ
amwa-224	40	11	near	near	ADP
amwa-224	40	12	the	the	DET
amwa-224	40	13	vinca	vinca	NOUN
amwa-224	40	14	-	-	PUNCT
amwa-224	40	15	binding	bind	VERB
amwa-224	40	16	site	site	NOUN
amwa-224	40	17	,	,	PUNCT
amwa-224	40	18	thereby	thereby	ADV
amwa-224	40	19	inhibiting	inhibit	VERB
amwa-224	40	20	microtubule	microtubule	NOUN
amwa-224	40	21	assembly	assembly	NOUN
amwa-224	40	22	and	and	CCONJ
amwa-224	40	23	inducing	induce	VERB
amwa-224	40	24	mitotic	mitotic	ADJ
amwa-224	40	25	arrest.31,82	arrest.31,82	NOUN
amwa-224	40	26	maytansinoids	maytansinoid	NOUN
amwa-224	40	27	commonly	commonly	ADV
amwa-224	40	28	used	use	VERB
amwa-224	40	29	in	in	ADP
amwa-224	40	30	adc	adc	PROPN
amwa-224	40	31	design	design	NOUN
amwa-224	40	32	include	include	VERB
amwa-224	40	33	2	2	NUM
amwa-224	40	34	thiomethyl	thiomethyl	NOUN
amwa-224	40	35	derivatives	derivative	NOUN
amwa-224	40	36	of	of	ADP
amwa-224	40	37	maytansine	maytansine	NOUN
amwa-224	40	38	:	:	PUNCT
amwa-224	40	39	mertansine	mertansine	VERB
amwa-224	40	40	and	and	CCONJ
amwa-224	40	41	ravtansine.1,31,83	ravtansine.1,31,83	ADJ
amwa-224	40	42	tubulysins	tubulysin	NOUN
amwa-224	40	43	comprise	comprise	VERB
amwa-224	40	44	a	a	DET
amwa-224	40	45	family	family	NOUN
amwa-224	40	46	of	of	ADP
amwa-224	40	47	more	more	ADV
amwa-224	40	48	recently	recently	ADV
amwa-224	40	49	discovered	discover	VERB
amwa-224	40	50	cytostatic	cytostatic	ADJ
amwa-224	40	51	peptides	peptide	NOUN
amwa-224	40	52	isolated	isolate	VERB
amwa-224	40	53	from	from	ADP
amwa-224	40	54	the	the	DET
amwa-224	40	55	myxobacteria	myxobacteria	NOUN
amwa-224	40	56	species	specie	NOUN
amwa-224	40	57	,	,	PUNCT
amwa-224	40	58	archangium	archangium	NOUN
amwa-224	40	59	gephyra	gephyra	NOUN
amwa-224	40	60	and	and	CCONJ
amwa-224	40	61	angiococcus	angiococcus	NOUN
amwa-224	40	62	disciformis	disciformis	NOUN
amwa-224	40	63	,	,	PUNCT
amwa-224	40	64	that	that	DET
amwa-224	40	65	act	act	VERB
amwa-224	40	66	by	by	ADP
amwa-224	40	67	inhibiting	inhibit	VERB
amwa-224	40	68	microtubule	microtubule	NOUN
amwa-224	40	69	polymerization	polymerization	NOUN
amwa-224	40	70	during	during	ADP
amwa-224	40	71	mitosis	mitosis	NOUN
amwa-224	40	72	,	,	PUNCT
amwa-224	40	73	thereby	thereby	ADV
amwa-224	40	74	inducing	induce	VERB
amwa-224	40	75	apoptosis.28,84,85	apoptosis.28,84,85	ADP
amwa-224	40	76	discussion	discussion	NOUN
amwa-224	40	77	rapid	rapid	ADJ
amwa-224	40	78	advances	advance	NOUN
amwa-224	40	79	in	in	ADP
amwa-224	40	80	molecular	molecular	ADJ
amwa-224	40	81	and	and	CCONJ
amwa-224	40	82	genomic	genomic	ADJ
amwa-224	40	83	technologies	technology	NOUN
amwa-224	40	84	over	over	ADP
amwa-224	40	85	the	the	DET
amwa-224	40	86	last	last	ADJ
amwa-224	40	87	several	several	ADJ
amwa-224	40	88	decades	decade	NOUN
amwa-224	40	89	have	have	AUX
amwa-224	40	90	ushered	usher	VERB
amwa-224	40	91	in	in	ADP
amwa-224	40	92	a	a	DET
amwa-224	40	93	new	new	ADJ
amwa-224	40	94	era	era	NOUN
amwa-224	40	95	of	of	ADP
amwa-224	40	96	precision	precision	NOUN
amwa-224	40	97	medicine	medicine	NOUN
amwa-224	40	98	and	and	CCONJ
amwa-224	40	99	led	lead	VERB
amwa-224	40	100	to	to	ADP
amwa-224	40	101	the	the	DET
amwa-224	40	102	increased	increase	VERB
amwa-224	40	103	use	use	NOUN
amwa-224	40	104	of	of	ADP
amwa-224	40	105	these	these	DET
amwa-224	40	106	technologies	technology	NOUN
amwa-224	40	107	as	as	ADP
amwa-224	40	108	important	important	ADJ
amwa-224	40	109	clinical	clinical	ADJ
amwa-224	40	110	tools	tool	NOUN
amwa-224	40	111	for	for	ADP
amwa-224	40	112	the	the	DET
amwa-224	40	113	diagnosis	diagnosis	NOUN
amwa-224	40	114	,	,	PUNCT
amwa-224	40	115	classification	classification	NOUN
amwa-224	40	116	,	,	PUNCT
amwa-224	40	117	and	and	CCONJ
amwa-224	40	118	treatment	treatment	NOUN
amwa-224	40	119	of	of	ADP
amwa-224	40	120	disease.86	disease.86	PROPN
amwa-224	40	121	as	as	ADP
amwa-224	40	122	the	the	DET
amwa-224	40	123	use	use	NOUN
amwa-224	40	124	of	of	ADP
amwa-224	40	125	precision	precision	NOUN
amwa-224	40	126	-	-	PUNCT
amwa-224	40	127	based	base	VERB
amwa-224	40	128	treatment	treatment	NOUN
amwa-224	40	129	strategies	strategy	NOUN
amwa-224	40	130	has	have	AUX
amwa-224	40	131	expanded	expand	VERB
amwa-224	40	132	,	,	PUNCT
amwa-224	40	133	biomarker	biomarker	NOUN
amwa-224	40	134	testing	testing	NOUN
amwa-224	40	135	has	have	AUX
amwa-224	40	136	become	become	VERB
amwa-224	40	137	an	an	DET
amwa-224	40	138	increasingly	increasingly	ADV
amwa-224	40	139	important	important	ADJ
amwa-224	40	140	prognostic	prognostic	ADJ
amwa-224	40	141	and	and	CCONJ
amwa-224	40	142	predictive	predictive	ADJ
amwa-224	40	143	tool	tool	NOUN
amwa-224	40	144	to	to	PART
amwa-224	40	145	improve	improve	VERB
amwa-224	40	146	disease	disease	NOUN
amwa-224	40	147	management	management	NOUN
amwa-224	40	148	and	and	CCONJ
amwa-224	40	149	enabled	enable	VERB
amwa-224	40	150	the	the	DET
amwa-224	40	151	development	development	NOUN
amwa-224	40	152	of	of	ADP
amwa-224	40	153	numerous	numerous	ADJ
amwa-224	40	154	targeted	target	VERB
amwa-224	40	155	therapies.88,89	therapies.88,89	NOUN
amwa-224	40	156	the	the	DET
amwa-224	40	157	effect	effect	NOUN
amwa-224	40	158	of	of	ADP
amwa-224	40	159	precision	precision	NOUN
amwa-224	40	160	-	-	PUNCT
amwa-224	40	161	based	base	VERB
amwa-224	40	162	approaches	approach	NOUN
amwa-224	40	163	on	on	ADP
amwa-224	40	164	the	the	DET
amwa-224	40	165	treatment	treatment	NOUN
amwa-224	40	166	landscape	landscape	NOUN
amwa-224	40	167	has	have	AUX
amwa-224	40	168	been	be	AUX
amwa-224	40	169	especially	especially	ADV
amwa-224	40	170	profound	profound	ADJ
amwa-224	40	171	in	in	ADP
amwa-224	40	172	the	the	DET
amwa-224	40	173	oncology	oncology	NOUN
amwa-224	40	174	space	space	NOUN
amwa-224	40	175	,	,	PUNCT
amwa-224	40	176	as	as	SCONJ
amwa-224	40	177	reflected	reflect	VERB
amwa-224	40	178	the	the	DET
amwa-224	40	179	growing	grow	VERB
amwa-224	40	180	number	number	NOUN
amwa-224	40	181	of	of	ADP
amwa-224	40	182	biomarker	biomarker	NOUN
amwa-224	40	183	-	-	PUNCT
amwa-224	40	184	driven	drive	VERB
amwa-224	40	185	clinical	clinical	ADJ
amwa-224	40	186	trials	trial	NOUN
amwa-224	40	187	,	,	PUNCT
amwa-224	40	188	which	which	PRON
amwa-224	40	189	increased	increase	VERB
amwa-224	40	190	from	from	ADP
amwa-224	40	191	15	15	NUM
amwa-224	40	192	%	%	NOUN
amwa-224	40	193	in	in	ADP
amwa-224	40	194	2000	2000	NUM
amwa-224	40	195	to	to	ADP
amwa-224	40	196	55	55	NUM
amwa-224	40	197	%	%	NOUN
amwa-224	40	198	in	in	ADP
amwa-224	40	199	2018.89	2018.89	NUM
amwa-224	40	200	although	although	SCONJ
amwa-224	40	201	targeted	targeted	ADJ
amwa-224	40	202	therapies	therapy	NOUN
amwa-224	40	203	have	have	AUX
amwa-224	40	204	led	lead	VERB
amwa-224	40	205	to	to	ADP
amwa-224	40	206	major	major	ADJ
amwa-224	40	207	improvements	improvement	NOUN
amwa-224	40	208	in	in	ADP
amwa-224	40	209	progression	progression	NOUN
amwa-224	40	210	-	-	PUNCT
amwa-224	40	211	free	free	ADJ
amwa-224	40	212	and	and	CCONJ
amwa-224	40	213	overall	overall	ADJ
amwa-224	40	214	survival	survival	NOUN
amwa-224	40	215	,	,	PUNCT
amwa-224	40	216	acquired	acquire	VERB
amwa-224	40	217	drug	drug	NOUN
amwa-224	40	218	resistance	resistance	NOUN
amwa-224	40	219	has	have	AUX
amwa-224	40	220	led	lead	VERB
amwa-224	40	221	to	to	ADP
amwa-224	40	222	associated	associate	VERB
amwa-224	40	223	therapeutic	therapeutic	ADJ
amwa-224	40	224	limitations	limitation	NOUN
amwa-224	40	225	and	and	CCONJ
amwa-224	40	226	the	the	DET
amwa-224	40	227	need	need	NOUN
amwa-224	40	228	for	for	ADP
amwa-224	40	229	other	other	ADJ
amwa-224	40	230	treatment	treatment	NOUN
amwa-224	40	231	options.86	options.86	NOUN
amwa-224	40	232	adcs	adcs	ADV
amwa-224	40	233	in	in	ADP
amwa-224	40	234	particular	particular	ADJ
amwa-224	40	235	represent	represent	VERB
amwa-224	40	236	a	a	DET
amwa-224	40	237	unique	unique	ADJ
amwa-224	40	238	treatment	treatment	NOUN
amwa-224	40	239	approach	approach	NOUN
amwa-224	40	240	that	that	PRON
amwa-224	40	241	combines	combine	VERB
amwa-224	40	242	precision	precision	NOUN
amwa-224	40	243	-	-	PUNCT
amwa-224	40	244	based	base	VERB
amwa-224	40	245	technology	technology	NOUN
amwa-224	40	246	used	use	VERB
amwa-224	40	247	in	in	ADP
amwa-224	40	248	targeted	target	VERB
amwa-224	40	249	therapy	therapy	NOUN
amwa-224	40	250	approaches	approach	VERB
amwa-224	40	251	with	with	ADP
amwa-224	40	252	chemotherapy	chemotherapy	NOUN
amwa-224	40	253	-	-	PUNCT
amwa-224	40	254	based	base	VERB
amwa-224	40	255	strategies	strategy	NOUN
amwa-224	40	256	using	use	VERB
amwa-224	40	257	cytotoxic	cytotoxic	ADJ
amwa-224	40	258	agents	agent	NOUN
amwa-224	40	259	with	with	ADP
amwa-224	40	260	greater	great	ADJ
amwa-224	40	261	potency	potency	NOUN
amwa-224	40	262	.	.	PUNCT
amwa-224	41	1	since	since	SCONJ
amwa-224	41	2	the	the	DET
amwa-224	41	3	approval	approval	NOUN
amwa-224	41	4	of	of	ADP
amwa-224	41	5	the	the	DET
amwa-224	41	6	first	first	ADJ
amwa-224	41	7	adc	adc	PROPN
amwa-224	41	8	in	in	ADP
amwa-224	41	9	2000	2000	NUM
amwa-224	41	10	,	,	PUNCT
amwa-224	41	11	continued	continue	VERB
amwa-224	41	12	technological	technological	ADJ
amwa-224	41	13	advancements	advancement	NOUN
amwa-224	41	14	have	have	AUX
amwa-224	41	15	led	lead	VERB
amwa-224	41	16	to	to	ADP
amwa-224	41	17	an	an	DET
amwa-224	41	18	explosion	explosion	NOUN
amwa-224	41	19	in	in	ADP
amwa-224	41	20	the	the	DET
amwa-224	41	21	number	number	NOUN
amwa-224	41	22	of	of	ADP
amwa-224	41	23	adcs	adcs	NOUN
amwa-224	41	24	under	under	ADP
amwa-224	41	25	clinical	clinical	ADJ
amwa-224	41	26	development	development	NOUN
amwa-224	41	27	over	over	ADP
amwa-224	41	28	the	the	DET
amwa-224	41	29	last	last	ADJ
amwa-224	41	30	few	few	ADJ
amwa-224	41	31	decades	decade	NOUN
amwa-224	41	32	.	.	PUNCT
amwa-224	42	1	as	as	ADP
amwa-224	42	2	of	of	ADP
amwa-224	42	3	2022	2022	NUM
amwa-224	42	4	,	,	PUNCT
amwa-224	42	5	a	a	DET
amwa-224	42	6	total	total	NOUN
amwa-224	42	7	of	of	ADP
amwa-224	42	8	12	12	NUM
amwa-224	42	9	adcs	adcs	ADJ
amwa-224	42	10	with	with	ADP
amwa-224	42	11	9	9	NUM
amwa-224	42	12	associated	associate	VERB
amwa-224	42	13	biomarker	biomarker	NOUN
amwa-224	42	14	targets	target	NOUN
amwa-224	42	15	have	have	AUX
amwa-224	42	16	been	be	AUX
amwa-224	42	17	approved	approve	VERB
amwa-224	42	18	for	for	ADP
amwa-224	42	19	use	use	NOUN
amwa-224	42	20	in	in	ADP
amwa-224	42	21	the	the	DET
amwa-224	42	22	treatment	treatment	NOUN
amwa-224	42	23	of	of	ADP
amwa-224	42	24	both	both	CCONJ
amwa-224	42	25	solid	solid	ADJ
amwa-224	42	26	tumor	tumor	NOUN
amwa-224	42	27	and	and	CCONJ
amwa-224	42	28	hematological	hematological	ADJ
amwa-224	42	29	malignancies.7,90	malignancies.7,90	NOUN
amwa-224	42	30	in	in	ADP
amwa-224	42	31	addition	addition	NOUN
amwa-224	42	32	,	,	PUNCT
amwa-224	42	33	over	over	ADP
amwa-224	42	34	80	80	NUM
amwa-224	42	35	adcs	adc	NOUN
amwa-224	42	36	are	be	AUX
amwa-224	42	37	currently	currently	ADV
amwa-224	42	38	being	be	AUX
amwa-224	42	39	evaluated	evaluate	VERB
amwa-224	42	40	in	in	ADP
amwa-224	42	41	clinical	clinical	ADJ
amwa-224	42	42	trials	trial	NOUN
amwa-224	42	43	,	,	PUNCT
amwa-224	42	44	suggesting	suggest	VERB
amwa-224	42	45	that	that	SCONJ
amwa-224	42	46	utilization	utilization	NOUN
amwa-224	42	47	of	of	ADP
amwa-224	42	48	these	these	DET
amwa-224	42	49	novel	novel	ADJ
amwa-224	42	50	agents	agent	NOUN
amwa-224	42	51	will	will	AUX
amwa-224	42	52	continue	continue	VERB
amwa-224	42	53	to	to	PART
amwa-224	42	54	increase	increase	VERB
amwa-224	42	55	.	.	PUNCT
amwa-224	43	1	most	most	ADV
amwa-224	43	2	recently	recently	ADV
amwa-224	43	3	,	,	PUNCT
amwa-224	43	4	the	the	DET
amwa-224	43	5	clinical	clinical	ADJ
amwa-224	43	6	development	development	NOUN
amwa-224	43	7	of	of	ADP
amwa-224	43	8	novel	novel	NOUN
amwa-224	43	9	adcs	adcs	NOUN
amwa-224	43	10	has	have	AUX
amwa-224	43	11	had	have	VERB
amwa-224	43	12	a	a	DET
amwa-224	43	13	profound	profound	ADJ
amwa-224	43	14	impact	impact	NOUN
amwa-224	43	15	on	on	ADP
amwa-224	43	16	the	the	DET
amwa-224	43	17	treatment	treatment	NOUN
amwa-224	43	18	landscape	landscape	NOUN
amwa-224	43	19	for	for	ADP
amwa-224	43	20	solid	solid	ADJ
amwa-224	43	21	tumors	tumor	NOUN
amwa-224	43	22	.	.	PUNCT
amwa-224	44	1	the	the	DET
amwa-224	44	2	destiny	destiny	PROPN
amwa-224	44	3	series	series	NOUN
amwa-224	44	4	of	of	ADP
amwa-224	44	5	clinical	clinical	ADJ
amwa-224	44	6	trials	trial	NOUN
amwa-224	44	7	,	,	PUNCT
amwa-224	44	8	investigated	investigate	VERB
amwa-224	44	9	the	the	DET
amwa-224	44	10	human	human	ADJ
amwa-224	44	11	epidermal	epidermal	ADJ
amwa-224	44	12	growth	growth	NOUN
amwa-224	44	13	factor	factor	NOUN
amwa-224	44	14	receptor	receptor	NOUN
amwa-224	44	15	2	2	NUM
amwa-224	44	16	(	(	PUNCT
amwa-224	44	17	her2)-directed	her2)-directe	VERB
amwa-224	44	18	adc	adc	PROPN
amwa-224	44	19	,	,	PUNCT
amwa-224	44	20	trastuzumab	trastuzumab	NOUN
amwa-224	44	21	deruxtecan	deruxtecan	NOUN
amwa-224	44	22	(	(	PUNCT
amwa-224	44	23	t	t	PROPN
amwa-224	44	24	-	-	PUNCT
amwa-224	44	25	dxd	dxd	NOUN
amwa-224	44	26	)	)	PUNCT
amwa-224	44	27	in	in	ADP
amwa-224	44	28	a	a	DET
amwa-224	44	29	number	number	NOUN
amwa-224	44	30	of	of	ADP
amwa-224	44	31	solid	solid	ADJ
amwa-224	44	32	tumor	tumor	NOUN
amwa-224	44	33	types.91	types.91	NOUN
amwa-224	44	34	resulting	result	VERB
amwa-224	44	35	data	datum	NOUN
amwa-224	44	36	from	from	ADP
amwa-224	44	37	these	these	DET
amwa-224	44	38	trials	trial	NOUN
amwa-224	44	39	,	,	PUNCT
amwa-224	44	40	led	lead	VERB
amwa-224	44	41	to	to	ADP
amwa-224	44	42	approved	approve	VERB
amwa-224	44	43	indications	indication	NOUN
amwa-224	44	44	in	in	ADP
amwa-224	44	45	her2	her2	NOUN
amwa-224	44	46	-	-	PUNCT
amwa-224	44	47	positive	positive	ADJ
amwa-224	44	48	metastatic	metastatic	ADJ
amwa-224	44	49	breast	breast	NOUN
amwa-224	44	50	cancer	cancer	NOUN
amwa-224	44	51	(	(	PUNCT
amwa-224	44	52	mbc	mbc	PROPN
amwa-224	44	53	)	)	PUNCT
amwa-224	44	54	,	,	PUNCT
amwa-224	44	55	her2	her2	PROPN
amwa-224	44	56	-	-	PUNCT
amwa-224	44	57	low	low	PROPN
amwa-224	44	58	mbc	mbc	PROPN
amwa-224	44	59	,	,	PUNCT
amwa-224	44	60	and	and	CCONJ
amwa-224	44	61	gastric	gastric	ADJ
amwa-224	44	62	or	or	CCONJ
amwa-224	44	63	gastroesophageal	gastroesophageal	VERB
amwa-224	44	64	cancer	cancer	NOUN
amwa-224	44	65	,	,	PUNCT
amwa-224	44	66	as	as	ADV
amwa-224	44	67	well	well	ADV
amwa-224	44	68	as	as	ADP
amwa-224	44	69	accelerated	accelerate	VERB
amwa-224	44	70	approval	approval	NOUN
amwa-224	44	71	in	in	ADP
amwa-224	44	72	non	non	ADJ
amwa-224	44	73	-	-	ADJ
amwa-224	44	74	small	small	ADJ
amwa-224	44	75	cell	cell	NOUN
amwa-224	44	76	lung	lung	NOUN
amwa-224	44	77	cancer.16,92	cancer.16,92	NOUN
amwa-224	44	78	-	-	PUNCT
amwa-224	44	79	95	95	NUM
amwa-224	44	80	notably	notably	ADV
amwa-224	44	81	,	,	PUNCT
amwa-224	44	82	destiny	destiny	NOUN
amwa-224	44	83	trial	trial	NOUN
amwa-224	44	84	data	datum	NOUN
amwa-224	44	85	surrounding	surround	VERB
amwa-224	44	86	t	t	PROPN
amwa-224	44	87	-	-	PUNCT
amwa-224	44	88	dxd	dxd	PROPN
amwa-224	44	89	in	in	ADP
amwa-224	44	90	mbc	mbc	PROPN
amwa-224	44	91	were	be	AUX
amwa-224	44	92	not	not	PART
amwa-224	44	93	only	only	ADV
amwa-224	44	94	unprecedented	unprecedented	ADJ
amwa-224	44	95	,	,	PUNCT
amwa-224	44	96	but	but	CCONJ
amwa-224	44	97	also	also	ADV
amwa-224	44	98	transformative	transformative	VERB
amwa-224	44	99	,	,	PUNCT
amwa-224	44	100	and	and	CCONJ
amwa-224	44	101	have	have	AUX
amwa-224	44	102	played	play	VERB
amwa-224	44	103	a	a	DET
amwa-224	44	104	major	major	NOUN
amwa-224	44	105	in	in	ADP
amwa-224	44	106	reshaping	reshape	VERB
amwa-224	44	107	how	how	SCONJ
amwa-224	44	108	her2	her2	VERB
amwa-224	44	109	expression	expression	NOUN
amwa-224	44	110	in	in	ADP
amwa-224	44	111	tumors	tumor	NOUN
amwa-224	44	112	is	be	AUX
amwa-224	44	113	assessed	assess	VERB
amwa-224	44	114	and	and	CCONJ
amwa-224	44	115	managed	manage	VERB
amwa-224	44	116	.	.	PUNCT
amwa-224	45	1	historically	historically	ADV
amwa-224	45	2	,	,	PUNCT
amwa-224	45	3	her2	her2	VERB
amwa-224	45	4	expression	expression	NOUN
amwa-224	45	5	assessed	assess	VERB
amwa-224	45	6	via	via	ADP
amwa-224	45	7	immunohistochemistry	immunohistochemistry	NOUN
amwa-224	45	8	methods	method	NOUN
amwa-224	45	9	has	have	AUX
amwa-224	45	10	been	be	AUX
amwa-224	45	11	associated	associate	VERB
amwa-224	45	12	with	with	ADP
amwa-224	45	13	a	a	DET
amwa-224	45	14	binary	binary	ADJ
amwa-224	45	15	classification	classification	NOUN
amwa-224	45	16	,	,	PUNCT
amwa-224	45	17	namely	namely	ADV
amwa-224	45	18	her2	her2	VERB
amwa-224	45	19	-	-	PUNCT
amwa-224	45	20	positive	positive	ADJ
amwa-224	45	21	or	or	CCONJ
amwa-224	45	22	her2negative.96	her2negative.96	NOUN
amwa-224	45	23	early	early	ADV
amwa-224	45	24	targeted	target	VERB
amwa-224	45	25	therapies	therapy	NOUN
amwa-224	45	26	directed	direct	VERB
amwa-224	45	27	toward	toward	ADP
amwa-224	45	28	the	the	DET
amwa-224	45	29	her2	her2	PROPN
amwa-224	45	30	receptor	receptor	NOUN
amwa-224	45	31	only	only	ADV
amwa-224	45	32	demonstrated	demonstrate	VERB
amwa-224	45	33	efficacy	efficacy	NOUN
amwa-224	45	34	in	in	ADP
amwa-224	45	35	her2	her2	PROPN
amwa-224	45	36	-	-	PUNCT
amwa-224	45	37	positive	positive	ADJ
amwa-224	45	38	mbc	mbc	NOUN
amwa-224	45	39	,	,	PUNCT
amwa-224	45	40	with	with	ADP
amwa-224	45	41	no	no	DET
amwa-224	45	42	effect	effect	NOUN
amwa-224	45	43	in	in	ADP
amwa-224	45	44	those	those	PRON
amwa-224	45	45	with	with	ADP
amwa-224	45	46	her2	her2	NOUN
amwa-224	45	47	-	-	PUNCT
amwa-224	45	48	negative	negative	ADJ
amwa-224	45	49	status.96	status.96	ADV
amwa-224	45	50	however	however	ADV
amwa-224	45	51	,	,	PUNCT
amwa-224	45	52	the	the	DET
amwa-224	45	53	unique	unique	ADJ
amwa-224	45	54	adc	adc	NOUN
amwa-224	45	55	design	design	NOUN
amwa-224	45	56	associated	associate	VERB
amwa-224	45	57	with	with	ADP
amwa-224	45	58	t	t	PROPN
amwa-224	45	59	-	-	PUNCT
amwa-224	45	60	dxd	dxd	PROPN
amwa-224	45	61	and	and	CCONJ
amwa-224	45	62	the	the	DET
amwa-224	45	63	resulting	result	VERB
amwa-224	45	64	bystander	bystander	NOUN
amwa-224	45	65	effect	effect	NOUN
amwa-224	45	66	have	have	AUX
amwa-224	45	67	expanded	expand	VERB
amwa-224	45	68	observed	observed	ADJ
amwa-224	45	69	therapeutic	therapeutic	ADJ
amwa-224	45	70	responses	response	NOUN
amwa-224	45	71	to	to	ADP
amwa-224	45	72	patients	patient	NOUN
amwa-224	45	73	with	with	ADP
amwa-224	45	74	lower	low	ADJ
amwa-224	45	75	levels	level	NOUN
amwa-224	45	76	of	of	ADP
amwa-224	45	77	her2	her2	PROPN
amwa-224	45	78	expression.97	expression.97	NOUN
amwa-224	45	79	conclusion	conclusion	NOUN
amwa-224	45	80	as	as	ADP
amwa-224	45	81	the	the	DET
amwa-224	45	82	incidence	incidence	NOUN
amwa-224	45	83	of	of	ADP
amwa-224	45	84	cancer	cancer	NOUN
amwa-224	45	85	increases	increase	NOUN
amwa-224	45	86	worldwide	worldwide	ADV
amwa-224	45	87	,	,	PUNCT
amwa-224	45	88	growing	grow	VERB
amwa-224	45	89	demand	demand	NOUN
amwa-224	45	90	for	for	ADP
amwa-224	45	91	safer	safe	ADJ
amwa-224	45	92	,	,	PUNCT
amwa-224	45	93	more	more	ADV
amwa-224	45	94	personalized	personalized	ADJ
amwa-224	45	95	cancer	cancer	NOUN
amwa-224	45	96	therapies	therapy	NOUN
amwa-224	45	97	with	with	ADP
amwa-224	45	98	fewer	few	ADJ
amwa-224	45	99	side	side	NOUN
amwa-224	45	100	effects	effect	NOUN
amwa-224	45	101	will	will	AUX
amwa-224	45	102	undoubtedly	undoubtedly	ADV
amwa-224	45	103	propel	propel	VERB
amwa-224	45	104	further	further	ADJ
amwa-224	45	105	advances	advance	NOUN
amwa-224	45	106	in	in	ADP
amwa-224	45	107	adc	adc	PROPN
amwa-224	45	108	technology	technology	NOUN
amwa-224	45	109	.	.	PUNCT
amwa-224	46	1	over	over	ADP
amwa-224	46	2	the	the	DET
amwa-224	46	3	last	last	ADJ
amwa-224	46	4	5	5	NUM
amwa-224	46	5	years	year	NOUN
amwa-224	46	6	alone	alone	ADV
amwa-224	46	7	,	,	PUNCT
amwa-224	46	8	39	39	NUM
amwa-224	46	9	clinical	clinical	ADJ
amwa-224	46	10	trials	trial	NOUN
amwa-224	46	11	have	have	AUX
amwa-224	46	12	investigated	investigate	VERB
amwa-224	46	13	over	over	ADP
amwa-224	46	14	19	19	NUM
amwa-224	46	15	adcs.98,99	adcs.98,99	NOUN
amwa-224	46	16	given	give	VERB
amwa-224	46	17	the	the	DET
amwa-224	46	18	pace	pace	NOUN
amwa-224	46	19	at	at	ADP
amwa-224	46	20	which	which	PRON
amwa-224	46	21	adc	adc	PROPN
amwa-224	46	22	therapeutics	therapeutic	NOUN
amwa-224	46	23	are	be	AUX
amwa-224	46	24	being	be	AUX
amwa-224	46	25	introduced	introduce	VERB
amwa-224	46	26	,	,	PUNCT
amwa-224	46	27	the	the	DET
amwa-224	46	28	need	need	NOUN
amwa-224	46	29	for	for	ADP
amwa-224	46	30	clear	clear	ADJ
amwa-224	46	31	and	and	CCONJ
amwa-224	46	32	accurate	accurate	ADJ
amwa-224	46	33	communication	communication	NOUN
amwa-224	46	34	of	of	ADP
amwa-224	46	35	information	information	NOUN
amwa-224	46	36	regarding	regard	VERB
amwa-224	46	37	these	these	DET
amwa-224	46	38	sophisticated	sophisticated	ADJ
amwa-224	46	39	treatments	treatment	NOUN
amwa-224	46	40	will	will	AUX
amwa-224	46	41	also	also	ADV
amwa-224	46	42	continue	continue	VERB
amwa-224	46	43	to	to	PART
amwa-224	46	44	grow	grow	VERB
amwa-224	46	45	.	.	PUNCT
amwa-224	47	1	we	we	PRON
amwa-224	47	2	as	as	SCONJ
amwa-224	47	3	medical	medical	ADJ
amwa-224	47	4	communicators	communicator	NOUN
amwa-224	47	5	must	must	AUX
amwa-224	47	6	make	make	VERB
amwa-224	47	7	it	it	PRON
amwa-224	47	8	our	our	PRON
amwa-224	47	9	mission	mission	NOUN
amwa-224	47	10	to	to	PART
amwa-224	47	11	educate	educate	VERB
amwa-224	47	12	ourselves	ourselves	PRON
amwa-224	47	13	and	and	CCONJ
amwa-224	47	14	our	our	PRON
amwa-224	47	15	readers	reader	NOUN
amwa-224	47	16	so	so	SCONJ
amwa-224	47	17	that	that	SCONJ
amwa-224	47	18	they	they	PRON
amwa-224	47	19	can	can	AUX
amwa-224	47	20	approach	approach	VERB
amwa-224	47	21	the	the	DET
amwa-224	47	22	literature	literature	NOUN
amwa-224	47	23	critically	critically	ADV
amwa-224	47	24	and	and	CCONJ
amwa-224	47	25	make	make	VERB
amwa-224	47	26	informed	informed	ADJ
amwa-224	47	27	decisions	decision	NOUN
amwa-224	47	28	about	about	ADP
amwa-224	47	29	their	their	PRON
amwa-224	47	30	use	use	NOUN
amwa-224	47	31	.	.	PUNCT
amwa-224	48	1	acknowledgments	acknowledgment	NOUN
amwa-224	48	2	we	we	PRON
amwa-224	48	3	thank	thank	VERB
amwa-224	48	4	yuqian	yuqian	PROPN
amwa-224	48	5	lu	lu	PROPN
amwa-224	48	6	,	,	PUNCT
amwa-224	48	7	ma	ma	PROPN
amwa-224	48	8	,	,	PUNCT
amwa-224	48	9	for	for	ADP
amwa-224	48	10	her	her	PRON
amwa-224	48	11	design	design	NOUN
amwa-224	48	12	of	of	ADP
amwa-224	48	13	the	the	DET
amwa-224	48	14	accompanying	accompany	VERB
amwa-224	48	15	figure	figure	NOUN
amwa-224	48	16	and	and	CCONJ
amwa-224	48	17	table	table	NOUN
amwa-224	48	18	.	.	PUNCT
amwa-224	49	1	author	author	NOUN
amwa-224	49	2	declaration	declaration	PROPN
amwa-224	49	3	and	and	CCONJ
amwa-224	49	4	disclosures	disclosure	NOUN
amwa-224	49	5	:	:	PUNCT
amwa-224	49	6	the	the	DET
amwa-224	49	7	author	author	NOUN
amwa-224	49	8	notes	note	VERB
amwa-224	49	9	no	no	DET
amwa-224	49	10	commercial	commercial	ADJ
amwa-224	49	11	associations	association	NOUN
amwa-224	49	12	that	that	PRON
amwa-224	49	13	may	may	AUX
amwa-224	49	14	pose	pose	VERB
amwa-224	49	15	a	a	DET
amwa-224	49	16	conflict	conflict	NOUN
amwa-224	49	17	of	of	ADP
amwa-224	49	18	interest	interest	NOUN
amwa-224	49	19	in	in	ADP
amwa-224	49	20	relation	relation	NOUN
amwa-224	49	21	to	to	ADP
amwa-224	49	22	this	this	DET
amwa-224	49	23	article	article	NOUN
amwa-224	49	24	.	.	PUNCT
amwa-224	50	1	author	author	NOUN
amwa-224	50	2	contact	contact	PROPN
amwa-224	50	3	:	:	PUNCT
amwa-224	51	1	lrxprecsionhealth@gmail.com	lrxprecsionhealth@gmail.com	X
amwa-224	51	2	references	reference	NOUN
amwa-224	51	3	1	1	NUM
amwa-224	52	1	.	.	PUNCT
amwa-224	52	2	fu	fu	PROPN
amwa-224	52	3	z	z	PROPN
amwa-224	52	4	,	,	PUNCT
amwa-224	52	5	li	li	PROPN
amwa-224	52	6	s	s	PROPN
amwa-224	52	7	,	,	PUNCT
amwa-224	52	8	han	han	PROPN
amwa-224	52	9	s	s	PROPN
amwa-224	52	10	,	,	PUNCT
amwa-224	52	11	shi	shi	PROPN
amwa-224	52	12	c	c	PROPN
amwa-224	52	13	,	,	PUNCT
amwa-224	52	14	zhang	zhang	PROPN
amwa-224	52	15	y.	y.	PROPN
amwa-224	52	16	antibody	antibody	PROPN
amwa-224	52	17	drug	drug	NOUN
amwa-224	52	18	conjugate	conjugate	VERB
amwa-224	52	19	:	:	PUNCT
amwa-224	52	20	the	the	DET
amwa-224	52	21	“	"	PUNCT
amwa-224	52	22	biological	biological	ADJ
amwa-224	52	23	missile	missile	NOUN
amwa-224	52	24	”	"	PUNCT
amwa-224	52	25	for	for	ADP
amwa-224	52	26	targeted	target	VERB
amwa-224	52	27	cancer	cancer	NOUN
amwa-224	52	28	therapy	therapy	NOUN
amwa-224	52	29	.	.	PUNCT
amwa-224	53	1	signal	signal	PROPN
amwa-224	53	2	transduct	transduct	NOUN
amwa-224	53	3	target	target	NOUN
amwa-224	53	4	ther	ther	ADV
amwa-224	53	5	.	.	PUNCT
amwa-224	54	1	2022;7(1):93	2022;7(1):93	NUM
amwa-224	54	2	.	.	PUNCT
amwa-224	54	3	doi:10.1038	doi:10.1038	NOUN
amwa-224	54	4	/	/	SYM
amwa-224	54	5	s41392	s41392	VERB
amwa-224	54	6	-	-	PUNCT
amwa-224	54	7	022	022	NUM
amwa-224	54	8	-	-	PUNCT
amwa-224	54	9	00947	00947	NUM
amwa-224	54	10	-	-	SYM
amwa-224	54	11	7	7	NUM
amwa-224	54	12	2	2	NUM
amwa-224	54	13	.	.	PUNCT
amwa-224	55	1	feld	feld	PROPN
amwa-224	55	2	j	j	PROPN
amwa-224	55	3	,	,	PUNCT
amwa-224	55	4	barta	barta	PROPN
amwa-224	55	5	sk	sk	PROPN
amwa-224	55	6	,	,	PUNCT
amwa-224	55	7	schinke	schinke	NOUN
amwa-224	55	8	c	c	NOUN
amwa-224	55	9	,	,	PUNCT
amwa-224	55	10	braunschweig	braunschweig	VERB
amwa-224	55	11	i	i	PRON
amwa-224	55	12	,	,	PUNCT
amwa-224	55	13	zhou	zhou	PROPN
amwa-224	55	14	y	y	PROPN
amwa-224	55	15	,	,	PUNCT
amwa-224	55	16	verma	verma	PROPN
amwa-224	55	17	ak	ak	PROPN
amwa-224	55	18	.	.	PROPN
amwa-224	55	19	linked	link	VERB
amwa-224	55	20	-	-	PUNCT
amwa-224	55	21	in	in	ADP
amwa-224	55	22	:	:	PUNCT
amwa-224	55	23	design	design	NOUN
amwa-224	55	24	and	and	CCONJ
amwa-224	55	25	efficacy	efficacy	NOUN
amwa-224	55	26	of	of	ADP
amwa-224	55	27	antibody	antibody	NOUN
amwa-224	55	28	drug	drug	NOUN
amwa-224	55	29	conjugates	conjugate	NOUN
amwa-224	55	30	in	in	ADP
amwa-224	55	31	oncology	oncology	NOUN
amwa-224	55	32	.	.	PUNCT
amwa-224	56	1	oncotarget	oncotarget	NOUN
amwa-224	56	2	.	.	PUNCT
amwa-224	57	1	2013;4(3):397	2013;4(3):397	X
amwa-224	57	2	-	-	SYM
amwa-224	57	3	412	412	NUM
amwa-224	57	4	.	.	PUNCT
amwa-224	57	5	doi	doi	NOUN
amwa-224	57	6	:	:	PUNCT
amwa-224	57	7	10.18632/	10.18632/	NUM
amwa-224	57	8	oncotarget.924	oncotarget.924	NUM
amwa-224	57	9	3	3	NUM
amwa-224	57	10	.	.	PUNCT
amwa-224	58	1	devita	devita	PROPN
amwa-224	58	2	vt	vt	PROPN
amwa-224	58	3	jr	jr	PROPN
amwa-224	58	4	,	,	PUNCT
amwa-224	58	5	chu	chu	PROPN
amwa-224	58	6	e.	e.	PROPN
amwa-224	58	7	a	a	DET
amwa-224	58	8	history	history	NOUN
amwa-224	58	9	of	of	ADP
amwa-224	58	10	cancer	cancer	NOUN
amwa-224	58	11	chemotherapy	chemotherapy	NOUN
amwa-224	58	12	.	.	PUNCT
amwa-224	59	1	cancer	cancer	NOUN
amwa-224	59	2	res	re	NOUN
amwa-224	59	3	.	.	PUNCT
amwa-224	60	1	2008;68(21):8643	2008;68(21):8643	NUM
amwa-224	60	2	-	-	SYM
amwa-224	60	3	8653	8653	NUM
amwa-224	60	4	.	.	PUNCT
amwa-224	61	1	doi:10.1158/0008	doi:10.1158/0008	NOUN
amwa-224	61	2	-	-	PUNCT
amwa-224	61	3	5472.can-07	5472.can-07	NOUN
amwa-224	61	4	-	-	PUNCT
amwa-224	61	5	6611	6611	NUM
amwa-224	61	6	4	4	NUM
amwa-224	61	7	.	.	PUNCT
amwa-224	61	8	köhler	köhler	PROPN
amwa-224	61	9	g	g	PROPN
amwa-224	61	10	,	,	PUNCT
amwa-224	61	11	milstein	milstein	PROPN
amwa-224	61	12	c.	c.	PROPN
amwa-224	61	13	continuous	continuous	ADJ
amwa-224	61	14	cultures	culture	NOUN
amwa-224	61	15	of	of	ADP
amwa-224	61	16	fused	fuse	VERB
amwa-224	61	17	cells	cell	NOUN
amwa-224	61	18	secreting	secrete	VERB
amwa-224	61	19	antibody	antibody	NOUN
amwa-224	61	20	of	of	ADP
amwa-224	61	21	predefined	predefine	VERB
amwa-224	61	22	specificity	specificity	NOUN
amwa-224	61	23	.	.	PUNCT
amwa-224	62	1	nature	nature	NOUN
amwa-224	62	2	.	.	PUNCT
amwa-224	63	1	1975;256(5517):495497	1975;256(5517):495497	NUM
amwa-224	63	2	.	.	PUNCT
amwa-224	64	1	doi:10.1038/256495a0	doi:10.1038/256495a0	ADP
amwa-224	64	2	http://www.amwajournal.org	http://www.amwajournal.org	X
amwa-224	64	3	amwajournal.org	amwajournal.org	X
amwa-224	64	4	33antibody	33antibody	NUM
amwa-224	64	5	-	-	PUNCT
amwa-224	64	6	drug	drug	NOUN
amwa-224	64	7	conjugates	conjugate	NOUN
amwa-224	64	8	5	5	NUM
amwa-224	64	9	.	.	PUNCT
amwa-224	64	10	tong	tong	PROPN
amwa-224	64	11	jtw	jtw	PROPN
amwa-224	64	12	,	,	PUNCT
amwa-224	64	13	harris	harris	PROPN
amwa-224	64	14	pwr	pwr	PROPN
amwa-224	64	15	,	,	PUNCT
amwa-224	64	16	brimble	brimble	ADJ
amwa-224	64	17	ma	ma	PROPN
amwa-224	64	18	,	,	PUNCT
amwa-224	64	19	kavianinia	kavianinia	PROPN
amwa-224	64	20	i.	i.	PROPN
amwa-224	64	21	an	an	DET
amwa-224	64	22	insight	insight	NOUN
amwa-224	64	23	into	into	ADP
amwa-224	64	24	fda	fda	PROPN
amwa-224	64	25	approved	approve	VERB
amwa-224	64	26	antibody	antibody	NOUN
amwa-224	64	27	-	-	PUNCT
amwa-224	64	28	drug	drug	NOUN
amwa-224	64	29	conjugates	conjugate	NOUN
amwa-224	64	30	for	for	ADP
amwa-224	64	31	cancer	cancer	NOUN
amwa-224	64	32	therapy	therapy	NOUN
amwa-224	64	33	.	.	PUNCT
amwa-224	65	1	molecules	molecule	NOUN
amwa-224	65	2	.	.	PUNCT
amwa-224	66	1	2021;26(19):5847	2021;26(19):5847	NUM
amwa-224	66	2	.	.	PUNCT
amwa-224	67	1	doi:10.3390	doi:10.3390	PROPN
amwa-224	67	2	/	/	SYM
amwa-224	67	3	molecules26195847	molecules26195847	PROPN
amwa-224	67	4	6	6	NUM
amwa-224	67	5	.	.	PUNCT
amwa-224	68	1	lorusso	lorusso	PROPN
amwa-224	68	2	pm	pm	PROPN
amwa-224	68	3	,	,	PUNCT
amwa-224	68	4	weiss	weiss	PROPN
amwa-224	68	5	d	d	PROPN
amwa-224	68	6	,	,	PUNCT
amwa-224	68	7	guardino	guardino	PROPN
amwa-224	68	8	e	e	PROPN
amwa-224	68	9	,	,	PUNCT
amwa-224	68	10	girish	girish	PROPN
amwa-224	68	11	s	s	PROPN
amwa-224	68	12	,	,	PUNCT
amwa-224	68	13	sliwkowski	sliwkowski	PROPN
amwa-224	68	14	mx	mx	PROPN
amwa-224	68	15	.	.	PROPN
amwa-224	68	16	trastuzumab	trastuzumab	NOUN
amwa-224	68	17	emtansine	emtansine	NOUN
amwa-224	68	18	:	:	PUNCT
amwa-224	68	19	a	a	DET
amwa-224	68	20	unique	unique	ADJ
amwa-224	68	21	antibody	antibody	NOUN
amwa-224	68	22	-	-	PUNCT
amwa-224	68	23	drug	drug	NOUN
amwa-224	68	24	conjugate	conjugate	NOUN
amwa-224	68	25	in	in	ADP
amwa-224	68	26	development	development	NOUN
amwa-224	68	27	for	for	ADP
amwa-224	68	28	human	human	ADJ
amwa-224	68	29	epidermal	epidermal	ADJ
amwa-224	68	30	growth	growth	NOUN
amwa-224	68	31	factor	factor	NOUN
amwa-224	68	32	receptor	receptor	NOUN
amwa-224	68	33	2	2	NUM
amwa-224	68	34	-	-	PUNCT
amwa-224	68	35	positive	positive	ADJ
amwa-224	68	36	cancer	cancer	NOUN
amwa-224	68	37	.	.	PUNCT
amwa-224	69	1	clin	clin	PROPN
amwa-224	69	2	cancer	cancer	NOUN
amwa-224	69	3	res	re	NOUN
amwa-224	69	4	.	.	PUNCT
amwa-224	70	1	2011;17(20):6437	2011;17(20):6437	NUM
amwa-224	70	2	-	-	SYM
amwa-224	70	3	6447	6447	NUM
amwa-224	70	4	.	.	PUNCT
amwa-224	71	1	doi:10.1158/1078	doi:10.1158/1078	ADV
amwa-224	71	2	-	-	PUNCT
amwa-224	71	3	0432.ccr-11	0432.ccr-11	NUM
amwa-224	71	4	-	-	NOUN
amwa-224	71	5	0762	0762	NUM
amwa-224	71	6	7	7	X
amwa-224	71	7	.	.	PUNCT
amwa-224	71	8	dean	dean	PROPN
amwa-224	71	9	aq	aq	PROPN
amwa-224	71	10	,	,	PUNCT
amwa-224	71	11	luo	luo	PROPN
amwa-224	71	12	s	s	PROPN
amwa-224	71	13	,	,	PUNCT
amwa-224	71	14	twomey	twomey	PROPN
amwa-224	71	15	jd	jd	PROPN
amwa-224	71	16	,	,	PUNCT
amwa-224	71	17	zhang	zhang	PROPN
amwa-224	71	18	b.	b.	PROPN
amwa-224	71	19	targeting	target	VERB
amwa-224	71	20	cancer	cancer	NOUN
amwa-224	71	21	with	with	ADP
amwa-224	71	22	antibody	antibody	NOUN
amwa-224	71	23	-	-	PUNCT
amwa-224	71	24	drug	drug	NOUN
amwa-224	71	25	conjugates	conjugate	NOUN
amwa-224	71	26	:	:	PUNCT
amwa-224	71	27	promises	promise	NOUN
amwa-224	71	28	and	and	CCONJ
amwa-224	71	29	challenges	challenge	NOUN
amwa-224	71	30	.	.	PUNCT
amwa-224	72	1	mabs	mab	NOUN
amwa-224	72	2	.	.	PUNCT
amwa-224	73	1	2021;13(1):1951427	2021;13(1):1951427	NUM
amwa-224	73	2	.	.	PUNCT
amwa-224	74	1	doi:10.1080/19420862.2021.1951427	doi:10.1080/19420862.2021.1951427	NOUN
amwa-224	74	2	8	8	NUM
amwa-224	74	3	.	.	PUNCT
amwa-224	75	1	adcetris	adcetris	NOUN
amwa-224	75	2	prescribing	prescribing	NOUN
amwa-224	75	3	information	information	NOUN
amwa-224	75	4	.	.	PUNCT
amwa-224	76	1	seagen	seagen	PROPN
amwa-224	76	2	inc	inc	PROPN
amwa-224	76	3	.	.	PROPN
amwa-224	76	4	published	publish	VERB
amwa-224	76	5	2022	2022	NUM
amwa-224	76	6	.	.	PUNCT
amwa-224	77	1	accessed	access	VERB
amwa-224	77	2	november	november	PROPN
amwa-224	77	3	1	1	NUM
amwa-224	77	4	,	,	PUNCT
amwa-224	77	5	2022	2022	NUM
amwa-224	77	6	.	.	PUNCT
amwa-224	78	1	https://www.adcetrispro.com/	https://www.adcetrispro.com/	ADJ
amwa-224	78	2	9	9	NUM
amwa-224	78	3	.	.	PUNCT
amwa-224	78	4	besponsa	besponsa	NOUN
amwa-224	78	5	prescribing	prescribing	NOUN
amwa-224	78	6	information	information	NOUN
amwa-224	78	7	.	.	PUNCT
amwa-224	79	1	pfizer	pfizer	PROPN
amwa-224	79	2	inc	inc	PROPN
amwa-224	79	3	.	.	PROPN
amwa-224	79	4	published	publish	VERB
amwa-224	79	5	2018	2018	NUM
amwa-224	79	6	.	.	PUNCT
amwa-224	80	1	accessed	access	VERB
amwa-224	80	2	november	november	PROPN
amwa-224	80	3	1	1	NUM
amwa-224	80	4	,	,	PUNCT
amwa-224	80	5	2022	2022	NUM
amwa-224	80	6	.	.	PUNCT
amwa-224	81	1	https://besponsa.pfizerpro.com/	https://besponsa.pfizerpro.com/	PROPN
amwa-224	81	2	10	10	NUM
amwa-224	81	3	.	.	PUNCT
amwa-224	82	1	blenrep	blenrep	NOUN
amwa-224	82	2	prescribing	prescribing	NOUN
amwa-224	82	3	information	information	NOUN
amwa-224	82	4	.	.	PUNCT
amwa-224	83	1	glaxosmithkline	glaxosmithkline	PROPN
amwa-224	83	2	.	.	PUNCT
amwa-224	83	3	published	publish	VERB
amwa-224	83	4	2022	2022	NUM
amwa-224	83	5	.	.	PUNCT
amwa-224	84	1	accessed	access	VERB
amwa-224	84	2	november	november	PROPN
amwa-224	84	3	1	1	NUM
amwa-224	84	4	,	,	PUNCT
amwa-224	84	5	2022	2022	NUM
amwa-224	84	6	.	.	PUNCT
amwa-224	85	1	https://gskpro.com/content/	https://gskpro.com/content/	PROPN
amwa-224	85	2	dam	dam	PROPN
amwa-224	85	3	/	/	SYM
amwa-224	85	4	global	global	ADJ
amwa-224	85	5	/	/	SYM
amwa-224	85	6	hcpportal	hcpportal	ADJ
amwa-224	85	7	/	/	SYM
amwa-224	85	8	en_us	en_us	PROPN
amwa-224	85	9	/	/	SYM
amwa-224	85	10	prescribing_information	prescribing_information	NOUN
amwa-224	85	11	/	/	SYM
amwa-224	85	12	blenrep/	blenrep/	NUM
amwa-224	85	13	pdf	pdf	NOUN
amwa-224	85	14	/	/	SYM
amwa-224	85	15	blenrep	blenrep	NOUN
amwa-224	85	16	-	-	PUNCT
amwa-224	85	17	pi	pi	NOUN
amwa-224	85	18	-	-	PUNCT
amwa-224	85	19	mg.pdf	mg.pdf	NOUN
amwa-224	85	20	11	11	NUM
amwa-224	85	21	.	.	PUNCT
amwa-224	86	1	lumoxiti	lumoxiti	PROPN
amwa-224	86	2	prescribing	prescribe	VERB
amwa-224	86	3	information	information	NOUN
amwa-224	86	4	.	.	PUNCT
amwa-224	87	1	astrazeneca	astrazeneca	PROPN
amwa-224	87	2	pharmaceuticals	pharmaceuticals	PROPN
amwa-224	87	3	lp	lp	PROPN
amwa-224	87	4	.	.	PUNCT
amwa-224	87	5	published	publish	VERB
amwa-224	87	6	2022	2022	NUM
amwa-224	87	7	.	.	PUNCT
amwa-224	88	1	accessed	access	VERB
amwa-224	88	2	november	november	PROPN
amwa-224	88	3	1	1	NUM
amwa-224	88	4	,	,	PUNCT
amwa-224	88	5	2022	2022	NUM
amwa-224	88	6	.	.	PUNCT
amwa-224	89	1	https://www	https://www	PROPN
amwa-224	89	2	.	.	PUNCT
amwa-224	89	3	lumoxiti.com/	lumoxiti.com/	PROPN
amwa-224	89	4	12	12	NUM
amwa-224	89	5	.	.	PUNCT
amwa-224	89	6	mylotarg	mylotarg	NOUN
amwa-224	89	7	prescribing	prescribing	NOUN
amwa-224	89	8	information	information	NOUN
amwa-224	89	9	.	.	PUNCT
amwa-224	90	1	pfizer	pfizer	PROPN
amwa-224	90	2	inc	inc	PROPN
amwa-224	90	3	.	.	PROPN
amwa-224	90	4	published	publish	VERB
amwa-224	90	5	2021	2021	NUM
amwa-224	90	6	.	.	PUNCT
amwa-224	91	1	accessed	access	VERB
amwa-224	91	2	november	november	PROPN
amwa-224	91	3	1	1	NUM
amwa-224	91	4	,	,	PUNCT
amwa-224	91	5	2022	2022	NUM
amwa-224	91	6	.	.	PUNCT
amwa-224	92	1	https://mylotarg.pfizerpro.com/	https://mylotarg.pfizerpro.com/	ADJ
amwa-224	92	2	13	13	NUM
amwa-224	92	3	.	.	PUNCT
amwa-224	92	4	polivy	polivy	NOUN
amwa-224	92	5	prescribing	prescribing	NOUN
amwa-224	92	6	information	information	NOUN
amwa-224	92	7	.	.	PUNCT
amwa-224	93	1	genentech	genentech	PROPN
amwa-224	93	2	inc	inc	PROPN
amwa-224	93	3	.	.	PROPN
amwa-224	93	4	published	publish	VERB
amwa-224	93	5	2020	2020	NUM
amwa-224	93	6	.	.	PUNCT
amwa-224	94	1	accessed	access	VERB
amwa-224	94	2	november	november	PROPN
amwa-224	94	3	1	1	NUM
amwa-224	94	4	,	,	PUNCT
amwa-224	94	5	2022	2022	NUM
amwa-224	94	6	.	.	PUNCT
amwa-224	95	1	https://www.polivy.com/hcp.html	https://www.polivy.com/hcp.html	PRON
amwa-224	95	2	14	14	NUM
amwa-224	95	3	.	.	PUNCT
amwa-224	96	1	zynlonta	zynlonta	NOUN
amwa-224	96	2	prescribing	prescribing	NOUN
amwa-224	96	3	information	information	NOUN
amwa-224	96	4	.	.	PUNCT
amwa-224	97	1	adc	adc	PROPN
amwa-224	97	2	therapeutics	therapeutic	NOUN
amwa-224	97	3	sa	sa	PROPN
amwa-224	97	4	.	.	PUNCT
amwa-224	98	1	published	publish	VERB
amwa-224	98	2	2022	2022	NUM
amwa-224	98	3	.	.	PUNCT
amwa-224	99	1	accessed	access	VERB
amwa-224	99	2	november	november	PROPN
amwa-224	99	3	1	1	NUM
amwa-224	99	4	,	,	PUNCT
amwa-224	99	5	2022	2022	NUM
amwa-224	99	6	.	.	PUNCT
amwa-224	100	1	https://www	https://www	PROPN
amwa-224	100	2	.	.	PUNCT
amwa-224	101	1	zynlontahcp.com/	zynlontahcp.com/	NOUN
amwa-224	101	2	15	15	NUM
amwa-224	101	3	.	.	PUNCT
amwa-224	101	4	elahere	elahere	ADJ
amwa-224	101	5	prescribing	prescribing	NOUN
amwa-224	101	6	information	information	NOUN
amwa-224	101	7	.	.	PUNCT
amwa-224	102	1	immunogen	immunogen	PROPN
amwa-224	102	2	,	,	PUNCT
amwa-224	102	3	inc	inc	PROPN
amwa-224	102	4	.	.	PROPN
amwa-224	102	5	published	publish	VERB
amwa-224	102	6	2022	2022	NUM
amwa-224	102	7	.	.	PUNCT
amwa-224	103	1	accessed	access	VERB
amwa-224	103	2	november	november	PROPN
amwa-224	103	3	23	23	NUM
amwa-224	103	4	,	,	PUNCT
amwa-224	103	5	2022	2022	NUM
amwa-224	103	6	.	.	PUNCT
amwa-224	104	1	https://www.immunogen	https://www.immunogen	PROPN
amwa-224	104	2	.	.	PUNCT
amwa-224	104	3	com	com	PROPN
amwa-224	104	4	/	/	SYM
amwa-224	104	5	wp	wp	PROPN
amwa-224	104	6	-	-	PUNCT
amwa-224	104	7	content	content	NOUN
amwa-224	104	8	/	/	SYM
amwa-224	104	9	uploads/2022/11	uploads/2022/11	PROPN
amwa-224	104	10	/	/	SYM
amwa-224	104	11	elahere_pi.pdf	elahere_pi.pdf	NOUN
amwa-224	104	12	16	16	NUM
amwa-224	104	13	.	.	PUNCT
amwa-224	105	1	enhertu	enhertu	ADJ
amwa-224	105	2	prescribing	prescribing	NOUN
amwa-224	105	3	information	information	NOUN
amwa-224	105	4	.	.	PUNCT
amwa-224	106	1	daiichi	daiichi	PROPN
amwa-224	106	2	sankyo	sankyo	PROPN
amwa-224	106	3	,	,	PUNCT
amwa-224	106	4	inc	inc	PROPN
amwa-224	106	5	.	.	PROPN
amwa-224	106	6	published	publish	VERB
amwa-224	106	7	2022	2022	NUM
amwa-224	106	8	.	.	PUNCT
amwa-224	107	1	accessed	access	VERB
amwa-224	107	2	november	november	PROPN
amwa-224	107	3	1	1	NUM
amwa-224	107	4	,	,	PUNCT
amwa-224	107	5	2022	2022	NUM
amwa-224	107	6	.	.	PUNCT
amwa-224	107	7	https://www.enhertuhcp.com/	https://www.enhertuhcp.com/	PROPN
amwa-224	107	8	en	en	PROPN
amwa-224	107	9	/	/	SYM
amwa-224	107	10	breast	breast	NOUN
amwa-224	107	11	17	17	NUM
amwa-224	107	12	.	.	PUNCT
amwa-224	108	1	kadcyla	kadcyla	ADJ
amwa-224	108	2	prescribing	prescribe	VERB
amwa-224	108	3	information	information	NOUN
amwa-224	108	4	.	.	PUNCT
amwa-224	109	1	genentech	genentech	PROPN
amwa-224	109	2	inc	inc	PROPN
amwa-224	109	3	.	.	PROPN
amwa-224	109	4	published	publish	VERB
amwa-224	109	5	2022	2022	NUM
amwa-224	109	6	.	.	PUNCT
amwa-224	110	1	accessed	access	VERB
amwa-224	110	2	november	november	PROPN
amwa-224	110	3	1	1	NUM
amwa-224	110	4	,	,	PUNCT
amwa-224	110	5	2022	2022	NUM
amwa-224	110	6	.	.	PUNCT
amwa-224	111	1	https://www.kadcyla-hcp.com/	https://www.kadcyla-hcp.com/	PROPN
amwa-224	111	2	18	18	NUM
amwa-224	111	3	.	.	PUNCT
amwa-224	111	4	padcev	padcev	ADJ
amwa-224	111	5	prescribing	prescribing	NOUN
amwa-224	111	6	information	information	NOUN
amwa-224	111	7	.	.	PUNCT
amwa-224	112	1	seagen	seagen	PROPN
amwa-224	112	2	inc	inc	PROPN
amwa-224	112	3	.	.	PROPN
amwa-224	112	4	published	publish	VERB
amwa-224	112	5	2022	2022	NUM
amwa-224	112	6	.	.	PUNCT
amwa-224	113	1	accessed	access	VERB
amwa-224	113	2	november	november	PROPN
amwa-224	113	3	1	1	NUM
amwa-224	113	4	,	,	PUNCT
amwa-224	113	5	2022	2022	NUM
amwa-224	113	6	.	.	PUNCT
amwa-224	114	1	https://www.padcev.com/hcp	https://www.padcev.com/hcp	ADV
amwa-224	114	2	19	19	NUM
amwa-224	114	3	.	.	PUNCT
amwa-224	114	4	tivdak	tivdak	PROPN
amwa-224	114	5	prescribing	prescribing	NOUN
amwa-224	114	6	information	information	NOUN
amwa-224	114	7	.	.	PUNCT
amwa-224	115	1	seagen	seagen	PROPN
amwa-224	115	2	inc	inc	PROPN
amwa-224	115	3	.	.	PROPN
amwa-224	115	4	published	publish	VERB
amwa-224	115	5	2022	2022	NUM
amwa-224	115	6	.	.	PUNCT
amwa-224	116	1	accessed	access	VERB
amwa-224	116	2	november	november	PROPN
amwa-224	116	3	1	1	NUM
amwa-224	116	4	,	,	PUNCT
amwa-224	116	5	2022	2022	NUM
amwa-224	116	6	.	.	PUNCT
amwa-224	117	1	https://www.tivdakhcp.com/	https://www.tivdakhcp.com/	PROPN
amwa-224	117	2	20	20	NUM
amwa-224	117	3	.	.	PUNCT
amwa-224	118	1	trodelvy	trodelvy	PROPN
amwa-224	118	2	prescribing	prescribing	NOUN
amwa-224	118	3	information	information	NOUN
amwa-224	118	4	.	.	PUNCT
amwa-224	119	1	gilead	gilead	PROPN
amwa-224	119	2	sciences	sciences	PROPN
amwa-224	119	3	,	,	PUNCT
amwa-224	119	4	inc	inc	PROPN
amwa-224	119	5	.	.	PROPN
amwa-224	119	6	published	publish	VERB
amwa-224	119	7	2022	2022	NUM
amwa-224	119	8	.	.	PUNCT
amwa-224	120	1	accessed	access	VERB
amwa-224	120	2	november	november	PROPN
amwa-224	120	3	1	1	NUM
amwa-224	120	4	,	,	PUNCT
amwa-224	120	5	2022	2022	NUM
amwa-224	120	6	.	.	PUNCT
amwa-224	121	1	https://www.trodelvyhcp.com/	https://www.trodelvyhcp.com/	PROPN
amwa-224	121	2	21	21	NUM
amwa-224	121	3	.	.	PUNCT
amwa-224	122	1	hafeez	hafeez	PROPN
amwa-224	122	2	u	u	PROPN
amwa-224	122	3	,	,	PUNCT
amwa-224	122	4	parakh	parakh	PROPN
amwa-224	122	5	s	s	PROPN
amwa-224	122	6	,	,	PUNCT
amwa-224	122	7	gan	gan	PROPN
amwa-224	122	8	hk	hk	PROPN
amwa-224	122	9	,	,	PUNCT
amwa-224	122	10	scott	scott	PROPN
amwa-224	122	11	am	be	AUX
amwa-224	122	12	.	.	PUNCT
amwa-224	123	1	antibody	antibody	NOUN
amwa-224	123	2	-	-	PUNCT
amwa-224	123	3	drug	drug	NOUN
amwa-224	123	4	conjugates	conjugate	NOUN
amwa-224	123	5	for	for	ADP
amwa-224	123	6	cancer	cancer	NOUN
amwa-224	123	7	therapy	therapy	NOUN
amwa-224	123	8	.	.	PUNCT
amwa-224	124	1	molecules	molecule	NOUN
amwa-224	124	2	.	.	PUNCT
amwa-224	125	1	2020;25(20):4764	2020;25(20):4764	NUM
amwa-224	125	2	.	.	PUNCT
amwa-224	126	1	doi:10.3390/	doi:10.3390/	PROPN
amwa-224	126	2	molecules25204764	molecules25204764	PROPN
amwa-224	126	3	22	22	NUM
amwa-224	126	4	.	.	PUNCT
amwa-224	127	1	giugliano	giugliano	PROPN
amwa-224	127	2	f	f	PROPN
amwa-224	127	3	,	,	PUNCT
amwa-224	127	4	corti	corti	PROPN
amwa-224	127	5	c	c	PROPN
amwa-224	127	6	,	,	PUNCT
amwa-224	127	7	tarantino	tarantino	PROPN
amwa-224	127	8	p	p	NOUN
amwa-224	127	9	,	,	PUNCT
amwa-224	127	10	michelini	michelini	NOUN
amwa-224	127	11	f	f	X
amwa-224	127	12	,	,	PUNCT
amwa-224	127	13	curigliano	curigliano	NOUN
amwa-224	127	14	g.	g.	NOUN
amwa-224	127	15	bystander	bystander	PROPN
amwa-224	127	16	effect	effect	NOUN
amwa-224	127	17	of	of	ADP
amwa-224	127	18	antibody	antibody	NOUN
amwa-224	127	19	-	-	PUNCT
amwa-224	127	20	drug	drug	NOUN
amwa-224	127	21	conjugates	conjugate	NOUN
amwa-224	127	22	:	:	PUNCT
amwa-224	127	23	fact	fact	NOUN
amwa-224	127	24	or	or	CCONJ
amwa-224	127	25	fiction	fiction	NOUN
amwa-224	127	26	?	?	PUNCT
amwa-224	128	1	curr	curr	PROPN
amwa-224	128	2	oncol	oncol	PROPN
amwa-224	128	3	rep	rep	PROPN
amwa-224	128	4	.	.	PROPN
amwa-224	128	5	2022;24(7):809	2022;24(7):809	NUM
amwa-224	128	6	-	-	SYM
amwa-224	128	7	817	817	NUM
amwa-224	128	8	.	.	PUNCT
amwa-224	129	1	doi:10.1007	doi:10.1007	PROPN
amwa-224	129	2	/	/	SYM
amwa-224	129	3	s11912	s11912	PROPN
amwa-224	129	4	-	-	PUNCT
amwa-224	129	5	022	022	NUM
amwa-224	129	6	-	-	PUNCT
amwa-224	129	7	01266	01266	NUM
amwa-224	129	8	-	-	SYM
amwa-224	129	9	4	4	NUM
amwa-224	129	10	23	23	NUM
amwa-224	129	11	.	.	PUNCT
amwa-224	130	1	trail	trail	PROPN
amwa-224	130	2	pa	pa	PROPN
amwa-224	130	3	,	,	PUNCT
amwa-224	130	4	dubowchik	dubowchik	PROPN
amwa-224	130	5	gm	gm	PROPN
amwa-224	130	6	,	,	PUNCT
amwa-224	130	7	lowinger	lowinger	NOUN
amwa-224	130	8	tb	tb	NOUN
amwa-224	130	9	.	.	PUNCT
amwa-224	130	10	antibody	antibody	NOUN
amwa-224	130	11	drug	drug	NOUN
amwa-224	130	12	conjugates	conjugate	NOUN
amwa-224	130	13	for	for	ADP
amwa-224	130	14	treatment	treatment	NOUN
amwa-224	130	15	of	of	ADP
amwa-224	130	16	breast	breast	NOUN
amwa-224	130	17	cancer	cancer	NOUN
amwa-224	130	18	:	:	PUNCT
amwa-224	130	19	novel	novel	ADJ
amwa-224	130	20	targets	target	NOUN
amwa-224	130	21	and	and	CCONJ
amwa-224	130	22	diverse	diverse	ADJ
amwa-224	130	23	approaches	approach	NOUN
amwa-224	130	24	in	in	ADP
amwa-224	130	25	adc	adc	PROPN
amwa-224	130	26	design	design	NOUN
amwa-224	130	27	.	.	PUNCT
amwa-224	131	1	pharmacol	pharmacol	NOUN
amwa-224	131	2	ther	ther	ADV
amwa-224	131	3	.	.	PUNCT
amwa-224	132	1	2018;181:126	2018;181:126	NUM
amwa-224	132	2	-	-	SYM
amwa-224	132	3	142	142	NUM
amwa-224	132	4	.	.	PUNCT
amwa-224	133	1	doi:10.1016	doi:10.1016	PROPN
amwa-224	133	2	/	/	SYM
amwa-224	133	3	j.pharmthera.2017.07.013	j.pharmthera.2017.07.013	PROPN
amwa-224	133	4	24	24	NUM
amwa-224	133	5	.	.	PUNCT
amwa-224	134	1	peters	peters	PROPN
amwa-224	134	2	c	c	PROPN
amwa-224	134	3	,	,	PUNCT
amwa-224	134	4	brown	brown	ADJ
amwa-224	134	5	s.	s.	PROPN
amwa-224	134	6	antibody	antibody	NOUN
amwa-224	134	7	-	-	PUNCT
amwa-224	134	8	drug	drug	NOUN
amwa-224	134	9	conjugates	conjugate	NOUN
amwa-224	134	10	as	as	ADP
amwa-224	134	11	novel	novel	ADJ
amwa-224	134	12	anti	anti	ADJ
amwa-224	134	13	-	-	ADJ
amwa-224	134	14	cancer	cancer	ADJ
amwa-224	134	15	chemotherapeutics	chemotherapeutic	NOUN
amwa-224	134	16	.	.	PUNCT
amwa-224	135	1	biosci	biosci	PROPN
amwa-224	135	2	rep	rep	PROPN
amwa-224	135	3	.	.	PROPN
amwa-224	135	4	2015;35(4):e00225	2015;35(4):e00225	PROPN
amwa-224	135	5	.	.	PUNCT
amwa-224	136	1	doi:10.1042/	doi:10.1042/	NUM
amwa-224	136	2	bsr20150089	bsr20150089	NOUN
amwa-224	136	3	25	25	NUM
amwa-224	136	4	.	.	PUNCT
amwa-224	137	1	singh	singh	PROPN
amwa-224	137	2	d	d	PROPN
amwa-224	137	3	,	,	PUNCT
amwa-224	137	4	dheer	dheer	NOUN
amwa-224	137	5	d	d	PROPN
amwa-224	137	6	,	,	PUNCT
amwa-224	137	7	samykutty	samykutty	ADP
amwa-224	137	8	a	a	PRON
amwa-224	137	9	,	,	PUNCT
amwa-224	137	10	shankar	shankar	PROPN
amwa-224	137	11	r.	r.	PROPN
amwa-224	137	12	antibody	antibody	NOUN
amwa-224	137	13	drug	drug	NOUN
amwa-224	137	14	conjugates	conjugate	NOUN
amwa-224	137	15	in	in	ADP
amwa-224	137	16	gastrointestinal	gastrointestinal	ADJ
amwa-224	137	17	cancer	cancer	NOUN
amwa-224	137	18	:	:	PUNCT
amwa-224	137	19	from	from	ADP
amwa-224	137	20	lab	lab	NOUN
amwa-224	137	21	to	to	ADP
amwa-224	137	22	clinical	clinical	ADJ
amwa-224	137	23	development	development	NOUN
amwa-224	137	24	.	.	PUNCT
amwa-224	138	1	j	j	PROPN
amwa-224	138	2	control	control	PROPN
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amwa-224	138	4	.	.	PUNCT
amwa-224	139	1	2021;340:1	2021;340:1	NUM
amwa-224	139	2	-	-	SYM
amwa-224	139	3	34	34	NUM
amwa-224	139	4	.	.	PUNCT
amwa-224	140	1	doi:10.1016	doi:10.1016	PROPN
amwa-224	140	2	/	/	SYM
amwa-224	140	3	j.	j.	PROPN
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amwa-224	141	2	.	.	PUNCT
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amwa-224	142	2	r	r	NOUN
amwa-224	142	3	,	,	PUNCT
amwa-224	142	4	de	de	X
amwa-224	142	5	la	la	X
amwa-224	142	6	torre	torre	PROPN
amwa-224	142	7	bg	bg	PROPN
amwa-224	142	8	,	,	PUNCT
amwa-224	142	9	albericio	albericio	PROPN
amwa-224	142	10	f.	f.	PROPN
amwa-224	142	11	linkers	linkers	PROPN
amwa-224	142	12	:	:	PUNCT
amwa-224	142	13	an	an	DET
amwa-224	142	14	assurance	assurance	NOUN
amwa-224	142	15	for	for	ADP
amwa-224	142	16	controlled	control	VERB
amwa-224	142	17	delivery	delivery	NOUN
amwa-224	142	18	of	of	ADP
amwa-224	142	19	antibody	antibody	NOUN
amwa-224	142	20	-	-	PUNCT
amwa-224	142	21	drug	drug	NOUN
amwa-224	142	22	conjugate	conjugate	NOUN
amwa-224	142	23	.	.	PUNCT
amwa-224	143	1	pharmaceutics	pharmaceutic	NOUN
amwa-224	143	2	.	.	PUNCT
amwa-224	144	1	2022;14(2):396	2022;14(2):396	NUM
amwa-224	144	2	.	.	PUNCT
amwa-224	145	1	doi:10.3390	doi:10.3390	NOUN
amwa-224	145	2	/	/	SYM
amwa-224	145	3	pharmaceutics14020396	pharmaceutics14020396	PROPN
amwa-224	145	4	27	27	NUM
amwa-224	145	5	.	.	PUNCT
amwa-224	146	1	you	you	PRON
amwa-224	146	2	j	j	PROPN
amwa-224	146	3	,	,	PUNCT
amwa-224	146	4	zhang	zhang	PROPN
amwa-224	146	5	j	j	PROPN
amwa-224	146	6	,	,	PUNCT
amwa-224	146	7	wang	wang	PROPN
amwa-224	146	8	j	j	PROPN
amwa-224	146	9	,	,	PUNCT
amwa-224	146	10	jin	jin	PROPN
amwa-224	146	11	m.	m.	PROPN
amwa-224	146	12	cysteine	cysteine	PROPN
amwa-224	146	13	-	-	PUNCT
amwa-224	146	14	based	base	VERB
amwa-224	146	15	coupling	coupling	NOUN
amwa-224	146	16	:	:	PUNCT
amwa-224	146	17	challenges	challenge	NOUN
amwa-224	146	18	and	and	CCONJ
amwa-224	146	19	solutions	solution	NOUN
amwa-224	146	20	.	.	PUNCT
amwa-224	147	1	bioconjug	bioconjug	NOUN
amwa-224	147	2	chem	chem	NOUN
amwa-224	147	3	.	.	PUNCT
amwa-224	148	1	2021;32(8):1525	2021;32(8):1525	NUM
amwa-224	148	2	-	-	SYM
amwa-224	148	3	1534	1534	NUM
amwa-224	148	4	.	.	PUNCT
amwa-224	149	1	doi:10.1021	doi:10.1021	ADJ
amwa-224	149	2	/	/	SYM
amwa-224	149	3	acs.bioconjchem.1c00213	acs.bioconjchem.1c00213	NOUN
amwa-224	149	4	28	28	NUM
amwa-224	149	5	.	.	PUNCT
amwa-224	150	1	beck	beck	PROPN
amwa-224	150	2	a	a	PRON
amwa-224	150	3	,	,	PUNCT
amwa-224	150	4	goetsch	goetsch	NOUN
amwa-224	150	5	l	l	NOUN
amwa-224	150	6	,	,	PUNCT
amwa-224	150	7	dumontet	dumontet	PROPN
amwa-224	150	8	c	c	PROPN
amwa-224	150	9	,	,	PUNCT
amwa-224	150	10	corvaïa	corvaïa	NOUN
amwa-224	150	11	n.	n.	NOUN
amwa-224	150	12	strategies	strategy	NOUN
amwa-224	150	13	and	and	CCONJ
amwa-224	150	14	challenges	challenge	NOUN
amwa-224	150	15	for	for	ADP
amwa-224	150	16	the	the	DET
amwa-224	150	17	next	next	ADJ
amwa-224	150	18	generation	generation	NOUN
amwa-224	150	19	of	of	ADP
amwa-224	150	20	antibody	antibody	NOUN
amwa-224	150	21	-	-	PUNCT
amwa-224	150	22	drug	drug	NOUN
amwa-224	150	23	conjugates	conjugate	NOUN
amwa-224	150	24	.	.	PUNCT
amwa-224	151	1	nat	nat	PROPN
amwa-224	151	2	rev	rev	VERB
amwa-224	151	3	drug	drug	NOUN
amwa-224	151	4	discov	discov	NOUN
amwa-224	151	5	.	.	PUNCT
amwa-224	152	1	2017;16(5):315	2017;16(5):315	PROPN
amwa-224	152	2	-	-	SYM
amwa-224	152	3	337	337	NUM
amwa-224	152	4	.	.	PUNCT
amwa-224	153	1	doi:10.1038/	doi:10.1038/	NOUN
amwa-224	153	2	nrd.2016.268	nrd.2016.268	PROPN
amwa-224	153	3	29	29	NUM
amwa-224	153	4	.	.	PUNCT
amwa-224	154	1	damelin	damelin	PROPN
amwa-224	154	2	m	m	PROPN
amwa-224	154	3	,	,	PUNCT
amwa-224	154	4	zhong	zhong	PROPN
amwa-224	154	5	w	w	PROPN
amwa-224	154	6	,	,	PUNCT
amwa-224	154	7	myers	myers	PROPN
amwa-224	154	8	j	j	PROPN
amwa-224	154	9	,	,	PUNCT
amwa-224	154	10	sapra	sapra	ADJ
amwa-224	154	11	p.	p.	NOUN
amwa-224	154	12	evolving	evolve	VERB
amwa-224	154	13	strategies	strategy	NOUN
amwa-224	154	14	for	for	ADP
amwa-224	154	15	target	target	NOUN
amwa-224	154	16	selection	selection	NOUN
amwa-224	154	17	for	for	ADP
amwa-224	154	18	antibody	antibody	NOUN
amwa-224	154	19	-	-	PUNCT
amwa-224	154	20	drug	drug	NOUN
amwa-224	154	21	conjugates	conjugate	NOUN
amwa-224	154	22	.	.	PUNCT
amwa-224	155	1	pharm	pharm	NOUN
amwa-224	155	2	res	re	NOUN
amwa-224	155	3	.	.	PUNCT
amwa-224	156	1	2015;32(11):3494	2015;32(11):3494	NUM
amwa-224	156	2	-	-	SYM
amwa-224	156	3	3507	3507	NUM
amwa-224	156	4	.	.	PUNCT
amwa-224	156	5	doi:10.1007	doi:10.1007	VERB
amwa-224	156	6	/	/	SYM
amwa-224	156	7	s11095	s11095	NOUN
amwa-224	156	8	-	-	PUNCT
amwa-224	156	9	015	015	NUM
amwa-224	156	10	-	-	PUNCT
amwa-224	156	11	1624	1624	NUM
amwa-224	156	12	-	-	SYM
amwa-224	156	13	3	3	NUM
amwa-224	156	14	30	30	NUM
amwa-224	156	15	.	.	PUNCT
amwa-224	157	1	carter	carter	PROPN
amwa-224	157	2	pj	pj	PROPN
amwa-224	157	3	,	,	PUNCT
amwa-224	157	4	senter	senter	PROPN
amwa-224	157	5	pd	pd	PROPN
amwa-224	157	6	.	.	PROPN
amwa-224	157	7	antibody	antibody	NOUN
amwa-224	157	8	-	-	PUNCT
amwa-224	157	9	drug	drug	NOUN
amwa-224	157	10	conjugates	conjugate	NOUN
amwa-224	157	11	for	for	ADP
amwa-224	157	12	cancer	cancer	NOUN
amwa-224	157	13	therapy	therapy	NOUN
amwa-224	157	14	.	.	PUNCT
amwa-224	158	1	cancer	cancer	NOUN
amwa-224	158	2	j.	j.	PROPN
amwa-224	158	3	2008;14(3):154	2008;14(3):154	PROPN
amwa-224	158	4	-	-	PUNCT
amwa-224	158	5	169	169	NUM
amwa-224	158	6	.	.	PUNCT
amwa-224	159	1	doi:10.1097/	doi:10.1097/	NUM
amwa-224	159	2	ppo.0b013e318172d704	ppo.0b013e318172d704	NOUN
amwa-224	159	3	31	31	NUM
amwa-224	159	4	.	.	PUNCT
amwa-224	160	1	nolting	nolte	VERB
amwa-224	160	2	b.	b.	PROPN
amwa-224	160	3	linker	linker	NOUN
amwa-224	160	4	technologies	technology	NOUN
amwa-224	160	5	for	for	ADP
amwa-224	160	6	antibody	antibody	NOUN
amwa-224	160	7	-	-	PUNCT
amwa-224	160	8	drug	drug	NOUN
amwa-224	160	9	conjugates	conjugate	NOUN
amwa-224	160	10	.	.	PUNCT
amwa-224	161	1	methods	method	NOUN
amwa-224	161	2	mol	mol	ADP
amwa-224	161	3	biol	biol	PROPN
amwa-224	161	4	.	.	PUNCT
amwa-224	162	1	2013;1045:71	2013;1045:71	NUM
amwa-224	162	2	-	-	SYM
amwa-224	162	3	100	100	NUM
amwa-224	162	4	.	.	PUNCT
amwa-224	163	1	doi:10.1007/978	doi:10.1007/978	NOUN
amwa-224	163	2	-	-	PUNCT
amwa-224	163	3	1	1	NUM
amwa-224	163	4	-	-	PUNCT
amwa-224	163	5	62703541	62703541	NUM
amwa-224	163	6	-	-	SYM
amwa-224	163	7	5_5	5_5	NUM
amwa-224	163	8	32	32	NUM
amwa-224	163	9	.	.	PUNCT
amwa-224	164	1	wang	wang	PROPN
amwa-224	164	2	w	w	PROPN
amwa-224	164	3	,	,	PUNCT
amwa-224	164	4	wang	wang	PROPN
amwa-224	164	5	eq	eq	NOUN
amwa-224	164	6	,	,	PUNCT
amwa-224	164	7	balthasar	balthasar	VERB
amwa-224	164	8	jp	jp	NOUN
amwa-224	164	9	.	.	PUNCT
amwa-224	164	10	monoclonal	monoclonal	NOUN
amwa-224	164	11	antibody	antibody	NOUN
amwa-224	164	12	pharmacokinetics	pharmacokinetic	NOUN
amwa-224	164	13	and	and	CCONJ
amwa-224	164	14	pharmacodynamics	pharmacodynamic	NOUN
amwa-224	164	15	.	.	PUNCT
amwa-224	165	1	clin	clin	PROPN
amwa-224	165	2	pharmacol	pharmacol	PROPN
amwa-224	165	3	ther	ther	ADV
amwa-224	165	4	.	.	PUNCT
amwa-224	166	1	2008;84(5):548	2008;84(5):548	NUM
amwa-224	166	2	-	-	PUNCT
amwa-224	166	3	558	558	NUM
amwa-224	166	4	.	.	PUNCT
amwa-224	167	1	doi:10.1038	doi:10.1038	NOUN
amwa-224	167	2	/	/	SYM
amwa-224	167	3	clpt.2008.170	clpt.2008.170	PROPN
amwa-224	167	4	33	33	NUM
amwa-224	167	5	.	.	PUNCT
amwa-224	167	6	brun	brun	PROPN
amwa-224	167	7	mp	mp	PROPN
amwa-224	167	8	,	,	PUNCT
amwa-224	167	9	gauzy	gauzy	NOUN
amwa-224	167	10	-	-	PUNCT
amwa-224	167	11	lazo	lazo	ADJ
amwa-224	167	12	l.	l.	PROPN
amwa-224	167	13	protocols	protocols	PROPN
amwa-224	167	14	for	for	ADP
amwa-224	167	15	lysine	lysine	NOUN
amwa-224	167	16	conjugation	conjugation	NOUN
amwa-224	167	17	.	.	PUNCT
amwa-224	168	1	methods	method	NOUN
amwa-224	168	2	mol	mol	ADP
amwa-224	168	3	biol	biol	PROPN
amwa-224	168	4	.	.	PUNCT
amwa-224	169	1	2013;1045:173	2013;1045:173	NUM
amwa-224	169	2	-	-	SYM
amwa-224	169	3	187	187	NUM
amwa-224	169	4	.	.	PUNCT
amwa-224	170	1	doi:10.1007/978	doi:10.1007/978	NOUN
amwa-224	170	2	-	-	PUNCT
amwa-224	170	3	1	1	NUM
amwa-224	170	4	-	-	PUNCT
amwa-224	170	5	62703	62703	NUM
amwa-224	170	6	-	-	SYM
amwa-224	170	7	541	541	NUM
amwa-224	170	8	-	-	PUNCT
amwa-224	170	9	5_10	5_10	NUM
amwa-224	170	10	34	34	NUM
amwa-224	170	11	.	.	PUNCT
amwa-224	171	1	chumsae	chumsae	PROPN
amwa-224	171	2	c	c	PROPN
amwa-224	171	3	,	,	PUNCT
amwa-224	171	4	gaza	gaza	PROPN
amwa-224	171	5	-	-	PUNCT
amwa-224	171	6	bulseco	bulseco	PROPN
amwa-224	171	7	g	g	NOUN
amwa-224	171	8	,	,	PUNCT
amwa-224	171	9	liu	liu	PROPN
amwa-224	171	10	h.	h.	PROPN
amwa-224	171	11	identification	identification	NOUN
amwa-224	171	12	and	and	CCONJ
amwa-224	171	13	localization	localization	NOUN
amwa-224	171	14	of	of	ADP
amwa-224	171	15	unpaired	unpaired	ADJ
amwa-224	171	16	cysteine	cysteine	NOUN
amwa-224	171	17	residues	residue	NOUN
amwa-224	171	18	in	in	ADP
amwa-224	171	19	monoclonal	monoclonal	NOUN
amwa-224	171	20	antibodies	antibody	NOUN
amwa-224	171	21	by	by	ADP
amwa-224	171	22	fluorescence	fluorescence	NOUN
amwa-224	171	23	labeling	labeling	NOUN
amwa-224	171	24	and	and	CCONJ
amwa-224	171	25	mass	mass	ADJ
amwa-224	171	26	spectrometry	spectrometry	NOUN
amwa-224	171	27	.	.	PUNCT
amwa-224	172	1	anal	anal	ADJ
amwa-224	172	2	chem	chem	NOUN
amwa-224	172	3	.	.	PUNCT
amwa-224	173	1	2009;81(15):6449	2009;81(15):6449	NUM
amwa-224	173	2	-	-	PUNCT
amwa-224	173	3	6457	6457	NUM
amwa-224	173	4	.	.	PUNCT
amwa-224	174	1	doi:10.1021	doi:10.1021	ADJ
amwa-224	174	2	/	/	SYM
amwa-224	174	3	ac900815z	ac900815z	NOUN
amwa-224	174	4	35	35	NUM
amwa-224	174	5	.	.	PUNCT
amwa-224	175	1	adumeau	adumeau	PROPN
amwa-224	175	2	p	p	PROPN
amwa-224	175	3	,	,	PUNCT
amwa-224	175	4	sharma	sharma	PROPN
amwa-224	175	5	sk	sk	PROPN
amwa-224	175	6	,	,	PUNCT
amwa-224	175	7	brent	brent	PROPN
amwa-224	175	8	c	c	PROPN
amwa-224	175	9	,	,	PUNCT
amwa-224	175	10	zeglis	zeglis	PROPN
amwa-224	175	11	bm	bm	PROPN
amwa-224	175	12	.	.	PUNCT
amwa-224	176	1	site	site	PROPN
amwa-224	176	2	-	-	PUNCT
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amwa-224	176	4	labeled	label	VERB
amwa-224	176	5	immunoconjugates	immunoconjugate	NOUN
amwa-224	176	6	for	for	ADP
amwa-224	176	7	molecular	molecular	ADJ
amwa-224	176	8	imaging	imaging	NOUN
amwa-224	176	9	—	—	PUNCT
amwa-224	176	10	part	part	NOUN
amwa-224	176	11	1	1	NUM
amwa-224	176	12	:	:	PUNCT
amwa-224	176	13	cysteine	cysteine	NOUN
amwa-224	176	14	residues	residue	NOUN
amwa-224	176	15	and	and	CCONJ
amwa-224	176	16	glycans	glycan	NOUN
amwa-224	176	17	.	.	PUNCT
amwa-224	177	1	mol	mol	ADP
amwa-224	177	2	imaging	imaging	PROPN
amwa-224	177	3	biol	biol	PROPN
amwa-224	177	4	.	.	PUNCT
amwa-224	178	1	2016;18(1):1	2016;18(1):1	NUM
amwa-224	178	2	-	-	SYM
amwa-224	178	3	17	17	NUM
amwa-224	178	4	.	.	PUNCT
amwa-224	179	1	doi:10.1007	doi:10.1007	VERB
amwa-224	179	2	/	/	SYM
amwa-224	179	3	s11307	s11307	PROPN
amwa-224	179	4	-	-	PUNCT
amwa-224	179	5	015	015	NUM
amwa-224	179	6	-	-	PUNCT
amwa-224	179	7	0919	0919	NUM
amwa-224	179	8	-	-	SYM
amwa-224	179	9	4	4	NUM
amwa-224	179	10	36	36	NUM
amwa-224	179	11	.	.	PUNCT
amwa-224	180	1	padlan	padlan	PROPN
amwa-224	180	2	ea	ea	PROPN
amwa-224	180	3	.	.	PUNCT
amwa-224	181	1	anatomy	anatomy	NOUN
amwa-224	181	2	of	of	ADP
amwa-224	181	3	the	the	DET
amwa-224	181	4	antibody	antibody	NOUN
amwa-224	181	5	molecule	molecule	NOUN
amwa-224	181	6	.	.	PUNCT
amwa-224	182	1	mol	mol	ADP
amwa-224	182	2	immunol	immunol	NOUN
amwa-224	182	3	.	.	PUNCT
amwa-224	183	1	1994;31(3):169	1994;31(3):169	NUM
amwa-224	183	2	-	-	SYM
amwa-224	183	3	217	217	NUM
amwa-224	183	4	.	.	PUNCT
amwa-224	184	1	doi:10.1016/0161	doi:10.1016/0161	VERB
amwa-224	184	2	-	-	PUNCT
amwa-224	184	3	5890(94)90001	5890(94)90001	NUM
amwa-224	184	4	-	-	PUNCT
amwa-224	184	5	9	9	NUM
amwa-224	184	6	37	37	NUM
amwa-224	184	7	.	.	PUNCT
amwa-224	185	1	shefet	shefet	NOUN
amwa-224	185	2	-	-	PUNCT
amwa-224	185	3	carasso	carasso	NOUN
amwa-224	185	4	l	l	NOUN
amwa-224	185	5	,	,	PUNCT
amwa-224	185	6	benhar	benhar	PROPN
amwa-224	185	7	i.	i.	PROPN
amwa-224	185	8	antibody	antibody	NOUN
amwa-224	185	9	-	-	PUNCT
amwa-224	185	10	targeted	target	VERB
amwa-224	185	11	drugs	drug	NOUN
amwa-224	185	12	and	and	CCONJ
amwa-224	185	13	drug	drug	NOUN
amwa-224	185	14	resistance	resistance	NOUN
amwa-224	185	15	—	—	PUNCT
amwa-224	185	16	challenges	challenge	NOUN
amwa-224	185	17	and	and	CCONJ
amwa-224	185	18	solutions	solution	NOUN
amwa-224	185	19	.	.	PUNCT
amwa-224	186	1	drug	drug	NOUN
amwa-224	186	2	resist	resist	VERB
amwa-224	186	3	updat	updat	PROPN
amwa-224	186	4	.	.	PUNCT
amwa-224	187	1	2015;18:36	2015;18:36	NUM
amwa-224	187	2	-	-	SYM
amwa-224	187	3	46	46	NUM
amwa-224	187	4	.	.	PUNCT
amwa-224	187	5	doi:10.1016	doi:10.1016	PROPN
amwa-224	187	6	/	/	SYM
amwa-224	187	7	j.drup.2014.11.001	j.drup.2014.11.001	PROPN
amwa-224	187	8	38	38	NUM
amwa-224	187	9	.	.	PUNCT
amwa-224	188	1	boylan	boylan	PROPN
amwa-224	188	2	nj	nj	PROPN
amwa-224	188	3	,	,	PUNCT
amwa-224	188	4	zhou	zhou	PROPN
amwa-224	188	5	w	w	PROPN
amwa-224	188	6	,	,	PUNCT
amwa-224	188	7	proos	proo	VERB
amwa-224	188	8	rj	rj	PROPN
amwa-224	188	9	,	,	PUNCT
amwa-224	188	10	tolbert	tolbert	PROPN
amwa-224	188	11	tj	tj	PROPN
amwa-224	188	12	,	,	PUNCT
amwa-224	188	13	wolfe	wolfe	PROPN
amwa-224	188	14	jl	jl	PROPN
amwa-224	188	15	,	,	PUNCT
amwa-224	188	16	laurence	laurence	PROPN
amwa-224	188	17	js	js	PROPN
amwa-224	188	18	.	.	PUNCT
amwa-224	189	1	conjugation	conjugation	PROPN
amwa-224	189	2	site	site	NOUN
amwa-224	189	3	heterogeneity	heterogeneity	NOUN
amwa-224	189	4	causes	cause	VERB
amwa-224	189	5	variable	variable	ADJ
amwa-224	189	6	electrostatic	electrostatic	ADJ
amwa-224	189	7	properties	property	NOUN
amwa-224	189	8	in	in	ADP
amwa-224	189	9	fc	fc	PROPN
amwa-224	189	10	conjugates	conjugate	NOUN
amwa-224	189	11	.	.	PUNCT
amwa-224	190	1	bioconjug	bioconjug	NOUN
amwa-224	190	2	chem	chem	NOUN
amwa-224	190	3	.	.	PUNCT
amwa-224	191	1	2013;24(6):10081016	2013;24(6):10081016	NUM
amwa-224	191	2	.	.	PUNCT
amwa-224	192	1	doi:10.1021	doi:10.1021	ADJ
amwa-224	192	2	/	/	SYM
amwa-224	192	3	bc4000564	bc4000564	VERB
amwa-224	192	4	39	39	NUM
amwa-224	192	5	.	.	PUNCT
amwa-224	193	1	wakankar	wakankar	NOUN
amwa-224	193	2	aa	aa	PROPN
amwa-224	193	3	,	,	PUNCT
amwa-224	193	4	feeney	feeney	PROPN
amwa-224	193	5	mb	mb	PROPN
amwa-224	193	6	,	,	PUNCT
amwa-224	193	7	rivera	rivera	PROPN
amwa-224	193	8	j	j	PROPN
amwa-224	193	9	,	,	PUNCT
amwa-224	193	10	et	et	PROPN
amwa-224	193	11	al	al	PROPN
amwa-224	193	12	.	.	PUNCT
amwa-224	193	13	physicochemical	physicochemical	ADJ
amwa-224	193	14	stability	stability	NOUN
amwa-224	193	15	of	of	ADP
amwa-224	193	16	the	the	DET
amwa-224	193	17	antibody	antibody	NOUN
amwa-224	193	18	-	-	PUNCT
amwa-224	193	19	drug	drug	NOUN
amwa-224	193	20	conjugate	conjugate	ADJ
amwa-224	193	21	trastuzumab	trastuzumab	NOUN
amwa-224	193	22	-	-	PUNCT
amwa-224	193	23	dm1	dm1	NOUN
amwa-224	193	24	:	:	PUNCT
amwa-224	193	25	changes	change	NOUN
amwa-224	193	26	due	due	ADJ
amwa-224	193	27	to	to	ADP
amwa-224	193	28	modification	modification	NOUN
amwa-224	193	29	and	and	CCONJ
amwa-224	193	30	conjugation	conjugation	NOUN
amwa-224	193	31	processes	process	NOUN
amwa-224	193	32	.	.	PUNCT
amwa-224	194	1	bioconjug	bioconjug	NOUN
amwa-224	194	2	chem	chem	NOUN
amwa-224	194	3	.	.	PUNCT
amwa-224	195	1	2010;21(9):1588	2010;21(9):1588	NUM
amwa-224	195	2	-	-	SYM
amwa-224	195	3	1595	1595	NUM
amwa-224	195	4	.	.	PUNCT
amwa-224	196	1	doi:10.1021	doi:10.1021	ADJ
amwa-224	196	2	/	/	SYM
amwa-224	196	3	bc900434c	bc900434c	NOUN
amwa-224	196	4	40	40	NUM
amwa-224	196	5	.	.	PUNCT
amwa-224	197	1	acchione	acchione	NOUN
amwa-224	197	2	m	m	PROPN
amwa-224	197	3	,	,	PUNCT
amwa-224	197	4	kwon	kwon	VERB
amwa-224	197	5	h	h	PROPN
amwa-224	197	6	,	,	PUNCT
amwa-224	197	7	jochheim	jochheim	PROPN
amwa-224	197	8	cm	cm	PROPN
amwa-224	197	9	,	,	PUNCT
amwa-224	197	10	atkins	atkins	PROPN
amwa-224	197	11	wm	wm	PROPN
amwa-224	197	12	.	.	PROPN
amwa-224	197	13	impact	impact	NOUN
amwa-224	197	14	of	of	ADP
amwa-224	197	15	linker	linker	NOUN
amwa-224	197	16	and	and	CCONJ
amwa-224	197	17	conjugation	conjugation	NOUN
amwa-224	197	18	chemistry	chemistry	NOUN
amwa-224	197	19	on	on	ADP
amwa-224	197	20	antigen	antigen	ADJ
amwa-224	197	21	binding	bind	VERB
amwa-224	197	22	,	,	PUNCT
amwa-224	197	23	fc	fc	NOUN
amwa-224	197	24	receptor	receptor	NOUN
amwa-224	197	25	binding	bind	VERB
amwa-224	197	26	and	and	CCONJ
amwa-224	197	27	thermal	thermal	ADJ
amwa-224	197	28	stability	stability	NOUN
amwa-224	197	29	of	of	ADP
amwa-224	197	30	model	model	NOUN
amwa-224	197	31	antibody	antibody	NOUN
amwa-224	197	32	-	-	PUNCT
amwa-224	197	33	drug	drug	NOUN
amwa-224	197	34	conjugates	conjugate	NOUN
amwa-224	197	35	.	.	PUNCT
amwa-224	198	1	mabs	mab	NOUN
amwa-224	198	2	.	.	PUNCT
amwa-224	199	1	2012;4(3):362	2012;4(3):362	NUM
amwa-224	199	2	-	-	SYM
amwa-224	199	3	372	372	NUM
amwa-224	199	4	.	.	PUNCT
amwa-224	199	5	doi:10.4161	doi:10.4161	PROPN
amwa-224	199	6	/	/	SYM
amwa-224	199	7	mabs.19449	mabs.19449	PROPN
amwa-224	199	8	41	41	NUM
amwa-224	199	9	.	.	PUNCT
amwa-224	200	1	hallam	hallam	PROPN
amwa-224	200	2	tj	tj	PROPN
amwa-224	200	3	,	,	PUNCT
amwa-224	200	4	wold	wold	ADJ
amwa-224	200	5	e	e	NOUN
amwa-224	200	6	,	,	PUNCT
amwa-224	200	7	wahl	wahl	PROPN
amwa-224	200	8	a	a	PRON
amwa-224	200	9	,	,	PUNCT
amwa-224	200	10	smider	smider	NOUN
amwa-224	200	11	vv	vv	NOUN
amwa-224	200	12	.	.	PUNCT
amwa-224	200	13	antibody	antibody	NOUN
amwa-224	200	14	conjugates	conjugate	NOUN
amwa-224	200	15	with	with	ADP
amwa-224	200	16	unnatural	unnatural	ADJ
amwa-224	200	17	amino	amino	ADJ
amwa-224	200	18	acids	acid	NOUN
amwa-224	200	19	.	.	PUNCT
amwa-224	201	1	molecular	molecular	ADJ
amwa-224	201	2	pharmaceutics	pharmaceutic	NOUN
amwa-224	201	3	.	.	PUNCT
amwa-224	202	1	2015;12:18481862	2015;12:18481862	X
amwa-224	202	2	.	.	X
amwa-224	202	3	doi	doi	NOUN
amwa-224	202	4	:	:	PUNCT
amwa-224	202	5	10.1021	10.1021	NUM
amwa-224	202	6	/	/	SYM
amwa-224	202	7	acs.molpharmaceut.5b00082	acs.molpharmaceut.5b00082	PROPN
amwa-224	202	8	42	42	NUM
amwa-224	202	9	.	.	PUNCT
amwa-224	203	1	hamblett	hamblett	PROPN
amwa-224	203	2	kj	kj	PROPN
amwa-224	203	3	,	,	PUNCT
amwa-224	203	4	senter	senter	PROPN
amwa-224	203	5	pd	pd	PROPN
amwa-224	203	6	,	,	PUNCT
amwa-224	203	7	chace	chace	PROPN
amwa-224	203	8	df	df	PROPN
amwa-224	203	9	,	,	PUNCT
amwa-224	203	10	et	et	PROPN
amwa-224	203	11	al	al	PROPN
amwa-224	203	12	.	.	PUNCT
amwa-224	203	13	effects	effect	NOUN
amwa-224	203	14	of	of	ADP
amwa-224	203	15	drug	drug	NOUN
amwa-224	203	16	loading	loading	NOUN
amwa-224	203	17	on	on	ADP
amwa-224	203	18	the	the	DET
amwa-224	203	19	antitumor	antitumor	PROPN
amwa-224	203	20	activity	activity	NOUN
amwa-224	203	21	of	of	ADP
amwa-224	203	22	a	a	DET
amwa-224	203	23	monoclonal	monoclonal	NOUN
amwa-224	203	24	antibody	antibody	NOUN
amwa-224	203	25	drug	drug	NOUN
amwa-224	203	26	conjugate	conjugate	VERB
amwa-224	203	27	.	.	PUNCT
amwa-224	204	1	clin	clin	PROPN
amwa-224	204	2	cancer	cancer	NOUN
amwa-224	204	3	res	re	NOUN
amwa-224	204	4	.	.	PUNCT
amwa-224	205	1	2004;10(20):7063	2004;10(20):7063	NUM
amwa-224	205	2	-	-	SYM
amwa-224	205	3	7070	7070	NUM
amwa-224	205	4	.	.	PUNCT
amwa-224	206	1	doi:10.1158/1078	doi:10.1158/1078	NOUN
amwa-224	206	2	-	-	PUNCT
amwa-224	206	3	0432	0432	NUM
amwa-224	206	4	.	.	PUNCT
amwa-224	207	1	ccr-04	ccr-04	PROPN
amwa-224	207	2	-	-	PUNCT
amwa-224	207	3	0789	0789	NUM
amwa-224	207	4	43	43	NUM
amwa-224	207	5	.	.	PUNCT
amwa-224	208	1	fukunaga	fukunaga	PROPN
amwa-224	208	2	a	a	PRON
amwa-224	208	3	,	,	PUNCT
amwa-224	208	4	maeta	maeta	PROPN
amwa-224	208	5	s	s	PROPN
amwa-224	208	6	,	,	PUNCT
amwa-224	208	7	reema	reema	NOUN
amwa-224	208	8	b	b	NOUN
amwa-224	208	9	,	,	PUNCT
amwa-224	208	10	nakakido	nakakido	PROPN
amwa-224	208	11	m	m	PROPN
amwa-224	208	12	,	,	PUNCT
amwa-224	208	13	tsumoto	tsumoto	PROPN
amwa-224	208	14	k.	k.	PROPN
amwa-224	208	15	improvement	improvement	NOUN
amwa-224	208	16	of	of	ADP
amwa-224	208	17	antibody	antibody	NOUN
amwa-224	208	18	affinity	affinity	NOUN
amwa-224	208	19	by	by	ADP
amwa-224	208	20	introduction	introduction	NOUN
amwa-224	208	21	of	of	ADP
amwa-224	208	22	basic	basic	ADJ
amwa-224	208	23	amino	amino	NOUN
amwa-224	208	24	acid	acid	NOUN
amwa-224	208	25	residues	residue	NOUN
amwa-224	208	26	into	into	ADP
amwa-224	208	27	the	the	DET
amwa-224	208	28	framework	framework	NOUN
amwa-224	208	29	region	region	NOUN
amwa-224	208	30	.	.	PUNCT
amwa-224	209	1	biochem	biochem	PROPN
amwa-224	209	2	biophys	biophys	PROPN
amwa-224	209	3	rep	rep	PROPN
amwa-224	209	4	.	.	PROPN
amwa-224	209	5	2018;15:81	2018;15:81	NUM
amwa-224	209	6	-	-	SYM
amwa-224	209	7	85	85	NUM
amwa-224	209	8	.	.	PUNCT
amwa-224	209	9	doi:10.1016	doi:10.1016	PROPN
amwa-224	209	10	/	/	SYM
amwa-224	209	11	j.bbrep.2018.07.005	j.bbrep.2018.07.005	PROPN
amwa-224	209	12	44	44	NUM
amwa-224	209	13	.	.	PUNCT
amwa-224	210	1	shen	shen	PROPN
amwa-224	210	2	bq	bq	PROPN
amwa-224	210	3	,	,	PUNCT
amwa-224	210	4	xu	xu	PROPN
amwa-224	211	1	k	k	PROPN
amwa-224	211	2	,	,	PUNCT
amwa-224	211	3	liu	liu	PROPN
amwa-224	211	4	l	l	PROPN
amwa-224	211	5	,	,	PUNCT
amwa-224	211	6	et	et	PROPN
amwa-224	211	7	al	al	PROPN
amwa-224	211	8	.	.	PUNCT
amwa-224	211	9	conjugation	conjugation	PROPN
amwa-224	211	10	site	site	NOUN
amwa-224	211	11	modulates	modulate	VERB
amwa-224	211	12	the	the	PRON
amwa-224	211	13	in	in	ADP
amwa-224	211	14	vivo	vivo	ADJ
amwa-224	211	15	stability	stability	NOUN
amwa-224	211	16	and	and	CCONJ
amwa-224	211	17	therapeutic	therapeutic	ADJ
amwa-224	211	18	activity	activity	NOUN
amwa-224	211	19	of	of	ADP
amwa-224	211	20	antibody	antibody	NOUN
amwa-224	211	21	-	-	PUNCT
amwa-224	211	22	drug	drug	NOUN
amwa-224	211	23	conjugates	conjugate	NOUN
amwa-224	211	24	.	.	PUNCT
amwa-224	212	1	nat	nat	PROPN
amwa-224	212	2	biotechnol	biotechnol	NOUN
amwa-224	212	3	.	.	PUNCT
amwa-224	213	1	2012;30(2):184	2012;30(2):184	NUM
amwa-224	213	2	-	-	SYM
amwa-224	213	3	189	189	NUM
amwa-224	213	4	.	.	PUNCT
amwa-224	214	1	doi:10.1038	doi:10.1038	NOUN
amwa-224	214	2	/	/	SYM
amwa-224	214	3	nbt.2108	nbt.2108	ADP
amwa-224	214	4	45	45	NUM
amwa-224	214	5	.	.	PUNCT
amwa-224	215	1	chen	chen	PROPN
amwa-224	215	2	xn	xn	PROPN
amwa-224	215	3	,	,	PUNCT
amwa-224	215	4	nguyen	nguyen	PROPN
amwa-224	215	5	m	m	PROPN
amwa-224	215	6	,	,	PUNCT
amwa-224	215	7	jacobson	jacobson	PROPN
amwa-224	215	8	f	f	PROPN
amwa-224	215	9	,	,	PUNCT
amwa-224	215	10	ouyang	ouyang	PROPN
amwa-224	215	11	j.	j.	PROPN
amwa-224	215	12	charge	charge	NOUN
amwa-224	215	13	-	-	PUNCT
amwa-224	215	14	based	base	VERB
amwa-224	215	15	analysis	analysis	NOUN
amwa-224	215	16	of	of	ADP
amwa-224	215	17	antibodies	antibody	NOUN
amwa-224	215	18	with	with	ADP
amwa-224	215	19	engineered	engineer	VERB
amwa-224	215	20	cysteines	cysteine	NOUN
amwa-224	215	21	:	:	PUNCT
amwa-224	215	22	from	from	ADP
amwa-224	215	23	multiple	multiple	ADJ
amwa-224	215	24	peaks	peak	NOUN
amwa-224	215	25	to	to	ADP
amwa-224	215	26	a	a	DET
amwa-224	215	27	single	single	ADJ
amwa-224	215	28	main	main	ADJ
amwa-224	215	29	peak	peak	NOUN
amwa-224	215	30	.	.	PUNCT
amwa-224	216	1	mabs	mab	NOUN
amwa-224	216	2	.	.	PUNCT
amwa-224	217	1	2009;1(6):563	2009;1(6):563	NUM
amwa-224	217	2	-	-	SYM
amwa-224	217	3	571	571	NUM
amwa-224	217	4	.	.	PUNCT
amwa-224	218	1	doi:10.4161/	doi:10.4161/	NUM
amwa-224	218	2	mabs.1.6.10058	mabs.1.6.10058	X
amwa-224	218	3	46	46	NUM
amwa-224	218	4	.	.	PUNCT
amwa-224	219	1	junutula	junutula	PROPN
amwa-224	219	2	jr	jr	PROPN
amwa-224	219	3	,	,	PUNCT
amwa-224	219	4	raab	raab	PROPN
amwa-224	219	5	h	h	PROPN
amwa-224	219	6	,	,	PUNCT
amwa-224	219	7	clark	clark	PROPN
amwa-224	219	8	s	s	PROPN
amwa-224	219	9	,	,	PUNCT
amwa-224	219	10	et	et	PROPN
amwa-224	219	11	al	al	PROPN
amwa-224	219	12	.	.	PROPN
amwa-224	219	13	site	site	NOUN
amwa-224	219	14	-	-	PUNCT
amwa-224	219	15	specific	specific	ADJ
amwa-224	219	16	conjugation	conjugation	NOUN
amwa-224	219	17	of	of	ADP
amwa-224	219	18	a	a	DET
amwa-224	219	19	cytotoxic	cytotoxic	ADJ
amwa-224	219	20	drug	drug	NOUN
amwa-224	219	21	to	to	ADP
amwa-224	219	22	an	an	DET
amwa-224	219	23	antibody	antibody	NOUN
amwa-224	219	24	improves	improve	VERB
amwa-224	219	25	the	the	DET
amwa-224	219	26	therapeutic	therapeutic	ADJ
amwa-224	219	27	index	index	NOUN
amwa-224	219	28	.	.	PUNCT
amwa-224	220	1	nat	nat	PROPN
amwa-224	220	2	biotechnol	biotechnol	NOUN
amwa-224	220	3	.	.	PUNCT
amwa-224	221	1	2008;26(8):925	2008;26(8):925	NUM
amwa-224	221	2	-	-	SYM
amwa-224	221	3	932	932	NUM
amwa-224	221	4	.	.	PUNCT
amwa-224	221	5	doi:10.1038	doi:10.1038	NOUN
amwa-224	221	6	/	/	SYM
amwa-224	221	7	nbt.1480	nbt.1480	NUM
amwa-224	221	8	47	47	NUM
amwa-224	221	9	.	.	PUNCT
amwa-224	222	1	zhou	zhou	PROPN
amwa-224	222	2	q.	q.	PROPN
amwa-224	222	3	site	site	PROPN
amwa-224	222	4	-	-	PUNCT
amwa-224	222	5	specific	specific	ADJ
amwa-224	222	6	antibody	antibody	NOUN
amwa-224	222	7	conjugation	conjugation	NOUN
amwa-224	222	8	for	for	ADP
amwa-224	222	9	adc	adc	PROPN
amwa-224	222	10	and	and	CCONJ
amwa-224	222	11	beyond	beyond	ADP
amwa-224	222	12	.	.	PUNCT
amwa-224	223	1	biomedicines	biomedicine	NOUN
amwa-224	223	2	.	.	PUNCT
amwa-224	224	1	2017;5(4):64	2017;5(4):64	NUM
amwa-224	224	2	.	.	PUNCT
amwa-224	225	1	doi:10.3390	doi:10.3390	PROPN
amwa-224	225	2	/	/	SYM
amwa-224	225	3	biomedicines5040064	biomedicines5040064	PROPN
amwa-224	225	4	http://www.amwajournal.org	http://www.amwajournal.org	PUNCT
amwa-224	225	5	https://www.adcetrispro.com/	https://www.adcetrispro.com/	NOUN
amwa-224	225	6	https://besponsa.pfizerpro.com/	https://besponsa.pfizerpro.com/	PROPN
amwa-224	225	7	https://gskpro.com/content/dam/global/hcpportal/en_us/prescribing_information/blenrep/pdf/blenrep-pi-mg.pdf	https://gskpro.com/content/dam/global/hcpportal/en_us/prescribing_information/blenrep/pdf/blenrep-pi-mg.pdf	NOUN
amwa-224	225	8	https://gskpro.com/content/dam/global/hcpportal/en_us/prescribing_information/blenrep/pdf/blenrep-pi-mg.pdf	https://gskpro.com/content/dam/global/hcpportal/en_us/prescribing_information/blenrep/pdf/blenrep-pi-mg.pdf	NOUN
amwa-224	225	9	https://gskpro.com/content/dam/global/hcpportal/en_us/prescribing_information/blenrep/pdf/blenrep-pi-mg.pdf	https://gskpro.com/content/dam/global/hcpportal/en_us/prescribing_information/blenrep/pdf/blenrep-pi-mg.pdf	NOUN
amwa-224	225	10	https://www.lumoxiti.com/	https://www.lumoxiti.com/	VERB
amwa-224	225	11	https://www.lumoxiti.com/	https://www.lumoxiti.com/	ADJ
amwa-224	225	12	https://mylotarg.pfizerpro.com/	https://mylotarg.pfizerpro.com/	ADJ
amwa-224	225	13	https://www.polivy.com/hcp.html	https://www.polivy.com/hcp.html	PROPN
amwa-224	225	14	https://www.zynlontahcp.com/	https://www.zynlontahcp.com/	NOUN
amwa-224	225	15	https://www.zynlontahcp.com/	https://www.zynlontahcp.com/	PROPN
amwa-224	225	16	https://www.immunogen.com/wp-content/uploads/2022/11/elahere_pi.pdf	https://www.immunogen.com/wp-content/uploads/2022/11/elahere_pi.pdf	PROPN
amwa-224	225	17	https://www.immunogen.com/wp-content/uploads/2022/11/elahere_pi.pdf	https://www.immunogen.com/wp-content/uploads/2022/11/elahere_pi.pdf	PROPN
amwa-224	225	18	https://www.enhertuhcp.com/en/breast	https://www.enhertuhcp.com/en/breast	AUX
amwa-224	225	19	https://www.enhertuhcp.com/en/breast	https://www.enhertuhcp.com/en/breast	VERB
amwa-224	225	20	https://www.kadcyla-hcp.com/	https://www.kadcyla-hcp.com/	PROPN
amwa-224	225	21	https://www.padcev.com/hcp	https://www.padcev.com/hcp	PROPN
amwa-224	225	22	https://www.tivdakhcp.com/	https://www.tivdakhcp.com/	VERB
amwa-224	225	23	https://www.trodelvyhcp.com/	https://www.trodelvyhcp.com/	NOUN
amwa-224	225	24	amwajournal.org	amwajournal.org	X
amwa-224	225	25	34antibody	34antibody	NUM
amwa-224	225	26	-	-	PUNCT
amwa-224	225	27	drug	drug	NOUN
amwa-224	225	28	conjugates	conjugate	NOUN
amwa-224	225	29	48	48	NUM
amwa-224	225	30	.	.	PUNCT
amwa-224	226	1	walsh	walsh	PROPN
amwa-224	226	2	sj	sj	PROPN
amwa-224	226	3	,	,	PUNCT
amwa-224	226	4	bargh	bargh	PROPN
amwa-224	226	5	jd	jd	PROPN
amwa-224	226	6	,	,	PUNCT
amwa-224	226	7	dannheim	dannheim	PROPN
amwa-224	226	8	fm	fm	PROPN
amwa-224	226	9	,	,	PUNCT
amwa-224	226	10	et	et	PROPN
amwa-224	226	11	al	al	PROPN
amwa-224	226	12	.	.	PROPN
amwa-224	226	13	site	site	NOUN
amwa-224	226	14	-	-	PUNCT
amwa-224	226	15	selective	selective	ADJ
amwa-224	226	16	modification	modification	NOUN
amwa-224	226	17	strategies	strategy	NOUN
amwa-224	226	18	in	in	ADP
amwa-224	226	19	antibody	antibody	NOUN
amwa-224	226	20	-	-	PUNCT
amwa-224	226	21	drug	drug	NOUN
amwa-224	226	22	conjugates	conjugate	NOUN
amwa-224	226	23	.	.	PUNCT
amwa-224	227	1	chem	chem	NOUN
amwa-224	227	2	soc	soc	NOUN
amwa-224	227	3	rev	rev	VERB
amwa-224	227	4	.	.	PUNCT
amwa-224	228	1	2021;50:1305	2021;50:1305	PROPN
amwa-224	228	2	-	-	PUNCT
amwa-224	228	3	1353	1353	NUM
amwa-224	228	4	.	.	PUNCT
amwa-224	229	1	doi	doi	NOUN
amwa-224	229	2	:	:	PUNCT
amwa-224	229	3	10.1039	10.1039	NUM
amwa-224	229	4	/	/	SYM
amwa-224	229	5	d0cs00310	d0cs00310	PROPN
amwa-224	229	6	g	g	NOUN
amwa-224	229	7	49	49	NUM
amwa-224	229	8	.	.	PUNCT
amwa-224	230	1	axup	axup	PROPN
amwa-224	230	2	jy	jy	PROPN
amwa-224	230	3	,	,	PUNCT
amwa-224	230	4	bajjuri	bajjuri	PROPN
amwa-224	230	5	km	km	PROPN
amwa-224	230	6	,	,	PUNCT
amwa-224	230	7	ritland	ritland	NOUN
amwa-224	230	8	m	m	PROPN
amwa-224	230	9	,	,	PUNCT
amwa-224	230	10	et	et	PROPN
amwa-224	230	11	al	al	PROPN
amwa-224	230	12	.	.	PUNCT
amwa-224	230	13	synthesis	synthesis	NOUN
amwa-224	230	14	of	of	ADP
amwa-224	230	15	site	site	NOUN
amwa-224	230	16	-	-	PUNCT
amwa-224	230	17	specific	specific	ADJ
amwa-224	230	18	antibody	antibody	NOUN
amwa-224	230	19	-	-	PUNCT
amwa-224	230	20	drug	drug	NOUN
amwa-224	230	21	conjugates	conjugate	NOUN
amwa-224	230	22	using	use	VERB
amwa-224	230	23	unnatural	unnatural	ADJ
amwa-224	230	24	amino	amino	ADJ
amwa-224	230	25	acids	acid	NOUN
amwa-224	230	26	.	.	PUNCT
amwa-224	231	1	proc	proc	PROPN
amwa-224	231	2	natl	natl	PROPN
amwa-224	231	3	acad	acad	PROPN
amwa-224	231	4	sci	sci	PROPN
amwa-224	231	5	usa	usa	PROPN
amwa-224	231	6	.	.	PUNCT
amwa-224	232	1	2012;109(40):16101	2012;109(40):16101	NUM
amwa-224	232	2	-	-	SYM
amwa-224	232	3	16106	16106	NUM
amwa-224	232	4	.	.	PUNCT
amwa-224	233	1	doi:10.1073/	doi:10.1073/	PROPN
amwa-224	233	2	pnas.1211023109	pnas.1211023109	PROPN
amwa-224	233	3	50	50	NUM
amwa-224	233	4	.	.	PUNCT
amwa-224	234	1	tian	tian	PROPN
amwa-224	234	2	f	f	PROPN
amwa-224	234	3	,	,	PUNCT
amwa-224	234	4	lu	lu	PROPN
amwa-224	234	5	y	y	PROPN
amwa-224	234	6	,	,	PUNCT
amwa-224	234	7	manibusan	manibusan	NOUN
amwa-224	234	8	a	a	PRON
amwa-224	234	9	,	,	PUNCT
amwa-224	234	10	et	et	PROPN
amwa-224	234	11	al	al	PROPN
amwa-224	234	12	.	.	PUNCT
amwa-224	235	1	a	a	DET
amwa-224	235	2	general	general	ADJ
amwa-224	235	3	approach	approach	NOUN
amwa-224	235	4	to	to	ADP
amwa-224	235	5	sitespecific	sitespecific	ADJ
amwa-224	235	6	antibody	antibody	NOUN
amwa-224	235	7	drug	drug	NOUN
amwa-224	235	8	conjugates	conjugate	NOUN
amwa-224	235	9	.	.	PUNCT
amwa-224	236	1	proc	proc	PROPN
amwa-224	236	2	natl	natl	PROPN
amwa-224	236	3	acad	acad	PROPN
amwa-224	236	4	sci	sci	PROPN
amwa-224	236	5	usa	usa	PROPN
amwa-224	236	6	.	.	PROPN
amwa-224	237	1	2014;111(5):1766	2014;111(5):1766	NUM
amwa-224	237	2	-	-	SYM
amwa-224	237	3	1771	1771	NUM
amwa-224	237	4	.	.	PUNCT
amwa-224	238	1	doi:10.1073	doi:10.1073	NOUN
amwa-224	238	2	/	/	PUNCT
amwa-224	239	1	pnas.1321237111	pnas.1321237111	PROPN
amwa-224	239	2	51	51	NUM
amwa-224	239	3	.	.	PUNCT
amwa-224	240	1	kim	kim	PROPN
amwa-224	240	2	eg	eg	PROPN
amwa-224	240	3	,	,	PUNCT
amwa-224	240	4	kim	kim	PROPN
amwa-224	240	5	km	km	PROPN
amwa-224	240	6	.	.	PUNCT
amwa-224	240	7	strategies	strategy	NOUN
amwa-224	240	8	and	and	CCONJ
amwa-224	240	9	advancement	advancement	NOUN
amwa-224	240	10	in	in	ADP
amwa-224	240	11	antibodydrug	antibodydrug	ADJ
amwa-224	240	12	conjugate	conjugate	ADJ
amwa-224	240	13	optimization	optimization	NOUN
amwa-224	240	14	for	for	ADP
amwa-224	240	15	targeted	target	VERB
amwa-224	240	16	cancer	cancer	NOUN
amwa-224	240	17	therapeutics	therapeutic	NOUN
amwa-224	240	18	.	.	PUNCT
amwa-224	241	1	biomol	biomol	NOUN
amwa-224	241	2	ther	ther	PROPN
amwa-224	241	3	(	(	PUNCT
amwa-224	241	4	seoul	seoul	PROPN
amwa-224	241	5	)	)	PUNCT
amwa-224	241	6	.	.	PUNCT
amwa-224	242	1	2015;23(6):493	2015;23(6):493	NUM
amwa-224	242	2	-	-	PUNCT
amwa-224	242	3	509	509	NUM
amwa-224	242	4	.	.	PUNCT
amwa-224	243	1	doi:10.4062/	doi:10.4062/	PROPN
amwa-224	243	2	biomolther.2015.116	biomolther.2015.116	VERB
amwa-224	243	3	52	52	NUM
amwa-224	243	4	.	.	PUNCT
amwa-224	244	1	agarwal	agarwal	PROPN
amwa-224	244	2	p	p	X
amwa-224	244	3	,	,	PUNCT
amwa-224	244	4	bertozzi	bertozzi	NOUN
amwa-224	244	5	cr	cr	PROPN
amwa-224	244	6	.	.	PUNCT
amwa-224	244	7	site	site	NOUN
amwa-224	244	8	-	-	PUNCT
amwa-224	244	9	specific	specific	ADJ
amwa-224	244	10	antibody	antibody	NOUN
amwa-224	244	11	-	-	PUNCT
amwa-224	244	12	drug	drug	NOUN
amwa-224	244	13	conjugates	conjugate	NOUN
amwa-224	244	14	:	:	PUNCT
amwa-224	244	15	the	the	DET
amwa-224	244	16	nexus	nexus	NOUN
amwa-224	244	17	of	of	ADP
amwa-224	244	18	bioorthogonal	bioorthogonal	ADJ
amwa-224	244	19	chemistry	chemistry	NOUN
amwa-224	244	20	,	,	PUNCT
amwa-224	244	21	protein	protein	NOUN
amwa-224	244	22	engineering	engineering	NOUN
amwa-224	244	23	,	,	PUNCT
amwa-224	244	24	and	and	CCONJ
amwa-224	244	25	drug	drug	NOUN
amwa-224	244	26	development	development	NOUN
amwa-224	244	27	.	.	PUNCT
amwa-224	245	1	bioconjug	bioconjug	NOUN
amwa-224	245	2	chem	chem	NOUN
amwa-224	245	3	.	.	PUNCT
amwa-224	246	1	2015;26(2):176	2015;26(2):176	NUM
amwa-224	246	2	-	-	SYM
amwa-224	246	3	192	192	NUM
amwa-224	246	4	.	.	PUNCT
amwa-224	247	1	doi:10.1021	doi:10.1021	PROPN
amwa-224	247	2	/	/	SYM
amwa-224	247	3	bc5004982	bc5004982	PROPN
amwa-224	247	4	53	53	NUM
amwa-224	247	5	.	.	PUNCT
amwa-224	248	1	cao	cao	PROPN
amwa-224	248	2	yj	yj	PROPN
amwa-224	248	3	,	,	PUNCT
amwa-224	248	4	yu	yu	PROPN
amwa-224	248	5	c	c	PROPN
amwa-224	248	6	,	,	PUNCT
amwa-224	248	7	wu	wu	PROPN
amwa-224	248	8	kl	kl	PROPN
amwa-224	248	9	,	,	PUNCT
amwa-224	248	10	et	et	PROPN
amwa-224	248	11	al	al	PROPN
amwa-224	248	12	.	.	PUNCT
amwa-224	248	13	synthesis	synthesis	NOUN
amwa-224	248	14	of	of	ADP
amwa-224	248	15	precision	precision	NOUN
amwa-224	248	16	antibody	antibody	NOUN
amwa-224	248	17	conjugates	conjugate	NOUN
amwa-224	248	18	using	use	VERB
amwa-224	248	19	proximity	proximity	NOUN
amwa-224	248	20	-	-	PUNCT
amwa-224	248	21	induced	induce	VERB
amwa-224	248	22	chemistry	chemistry	NOUN
amwa-224	248	23	.	.	PUNCT
amwa-224	249	1	theranostics	theranostic	NOUN
amwa-224	249	2	.	.	PUNCT
amwa-224	250	1	2021;11(18):9107	2021;11(18):9107	X
amwa-224	250	2	-	-	SYM
amwa-224	250	3	9117	9117	NUM
amwa-224	250	4	.	.	PUNCT
amwa-224	251	1	doi:10.7150	doi:10.7150	PROPN
amwa-224	251	2	/	/	SYM
amwa-224	252	1	thno.62444	thno.62444	PROPN
amwa-224	252	2	54	54	NUM
amwa-224	252	3	.	.	PUNCT
amwa-224	253	1	balendiran	balendiran	PROPN
amwa-224	253	2	gk	gk	PROPN
amwa-224	253	3	,	,	PUNCT
amwa-224	253	4	dabur	dabur	PROPN
amwa-224	253	5	r	r	PROPN
amwa-224	253	6	,	,	PUNCT
amwa-224	253	7	fraser	fraser	PROPN
amwa-224	253	8	d.	d.	PROPN
amwa-224	253	9	the	the	DET
amwa-224	253	10	role	role	NOUN
amwa-224	253	11	of	of	ADP
amwa-224	253	12	glutathione	glutathione	NOUN
amwa-224	253	13	in	in	ADP
amwa-224	253	14	cancer	cancer	NOUN
amwa-224	253	15	.	.	PUNCT
amwa-224	254	1	cell	cell	NOUN
amwa-224	254	2	biochem	biochem	PROPN
amwa-224	254	3	funct	funct	NOUN
amwa-224	254	4	.	.	PUNCT
amwa-224	255	1	2004;22(6):343	2004;22(6):343	NUM
amwa-224	255	2	-	-	PUNCT
amwa-224	255	3	352	352	NUM
amwa-224	255	4	.	.	PUNCT
amwa-224	256	1	doi:10.1002/	doi:10.1002/	NUM
amwa-224	256	2	cbf.1149	cbf.1149	NUM
amwa-224	256	3	55	55	NUM
amwa-224	256	4	.	.	PUNCT
amwa-224	257	1	sanderson	sanderson	PROPN
amwa-224	257	2	rj	rj	PROPN
amwa-224	257	3	,	,	PUNCT
amwa-224	257	4	hering	hering	PROPN
amwa-224	257	5	ma	ma	PROPN
amwa-224	257	6	,	,	PUNCT
amwa-224	257	7	james	james	PROPN
amwa-224	257	8	sf	sf	PROPN
amwa-224	257	9	,	,	PUNCT
amwa-224	257	10	et	et	PROPN
amwa-224	257	11	al	al	PROPN
amwa-224	257	12	.	.	PROPN
amwa-224	258	1	in	in	ADP
amwa-224	258	2	vivo	vivo	ADJ
amwa-224	258	3	druglinker	druglinker	NOUN
amwa-224	258	4	stability	stability	NOUN
amwa-224	258	5	of	of	ADP
amwa-224	258	6	an	an	DET
amwa-224	258	7	anti	anti	ADJ
amwa-224	258	8	-	-	ADJ
amwa-224	258	9	cd30	cd30	ADJ
amwa-224	258	10	dipeptide	dipeptide	NOUN
amwa-224	258	11	-	-	PUNCT
amwa-224	258	12	linked	link	VERB
amwa-224	258	13	auristatin	auristatin	ADJ
amwa-224	258	14	immunoconjugate	immunoconjugate	NOUN
amwa-224	258	15	.	.	PUNCT
amwa-224	259	1	clin	clin	PROPN
amwa-224	259	2	cancer	cancer	NOUN
amwa-224	259	3	res	re	NOUN
amwa-224	259	4	.	.	PROPN
amwa-224	260	1	2005;11(2	2005;11(2	NUM
amwa-224	260	2	pt	pt	INTJ
amwa-224	260	3	1):843	1):843	NUM
amwa-224	260	4	-	-	PUNCT
amwa-224	260	5	852	852	NUM
amwa-224	260	6	.	.	PUNCT
amwa-224	261	1	56	56	NUM
amwa-224	261	2	.	.	PUNCT
amwa-224	262	1	erickson	erickson	PROPN
amwa-224	262	2	hk	hk	PROPN
amwa-224	262	3	,	,	PUNCT
amwa-224	262	4	park	park	PROPN
amwa-224	262	5	pu	pu	PROPN
amwa-224	262	6	,	,	PUNCT
amwa-224	262	7	widdison	widdison	PROPN
amwa-224	262	8	wc	wc	PROPN
amwa-224	262	9	,	,	PUNCT
amwa-224	262	10	et	et	PROPN
amwa-224	262	11	al	al	PROPN
amwa-224	262	12	.	.	PROPN
amwa-224	262	13	antibodymaytansinoid	antibodymaytansinoid	PROPN
amwa-224	262	14	conjugates	conjugate	NOUN
amwa-224	262	15	are	be	AUX
amwa-224	262	16	activated	activate	VERB
amwa-224	262	17	in	in	ADP
amwa-224	262	18	targeted	target	VERB
amwa-224	262	19	cancer	cancer	NOUN
amwa-224	262	20	cells	cell	NOUN
amwa-224	262	21	by	by	ADP
amwa-224	262	22	lysosomal	lysosomal	ADJ
amwa-224	262	23	degradation	degradation	NOUN
amwa-224	262	24	and	and	CCONJ
amwa-224	262	25	linker	linker	NOUN
amwa-224	262	26	-	-	PUNCT
amwa-224	262	27	dependent	dependent	ADJ
amwa-224	262	28	intracellular	intracellular	ADJ
amwa-224	262	29	processing	processing	NOUN
amwa-224	262	30	.	.	PUNCT
amwa-224	263	1	cancer	cancer	NOUN
amwa-224	263	2	res	re	NOUN
amwa-224	263	3	.	.	PUNCT
amwa-224	264	1	2006;66(8):4426	2006;66(8):4426	NUM
amwa-224	264	2	-	-	SYM
amwa-224	264	3	4433	4433	NUM
amwa-224	264	4	.	.	PUNCT
amwa-224	265	1	doi:10.1158/00085472.can-05	doi:10.1158/00085472.can-05	PROPN
amwa-224	265	2	-	-	PUNCT
amwa-224	265	3	4489	4489	NUM
amwa-224	265	4	57	57	NUM
amwa-224	265	5	.	.	PUNCT
amwa-224	266	1	pietersz	pietersz	PROPN
amwa-224	266	2	ga	ga	PROPN
amwa-224	266	3	,	,	PUNCT
amwa-224	266	4	krauer	krauer	PROPN
amwa-224	266	5	k.	k.	PROPN
amwa-224	266	6	antibody	antibody	NOUN
amwa-224	266	7	-	-	PUNCT
amwa-224	266	8	targeted	target	VERB
amwa-224	266	9	drugs	drug	NOUN
amwa-224	266	10	for	for	ADP
amwa-224	266	11	the	the	DET
amwa-224	266	12	therapy	therapy	NOUN
amwa-224	266	13	of	of	ADP
amwa-224	266	14	cancer	cancer	NOUN
amwa-224	266	15	.	.	PUNCT
amwa-224	267	1	j	j	PROPN
amwa-224	267	2	drug	drug	NOUN
amwa-224	267	3	target	target	PROPN
amwa-224	267	4	.	.	PUNCT
amwa-224	268	1	1994;2(3):183	1994;2(3):183	NUM
amwa-224	268	2	-	-	SYM
amwa-224	268	3	215	215	NUM
amwa-224	268	4	.	.	PUNCT
amwa-224	269	1	doi:10.3109/10611869408996804	doi:10.3109/10611869408996804	VERB
amwa-224	269	2	58	58	NUM
amwa-224	269	3	.	.	PUNCT
amwa-224	270	1	shor	shor	PROPN
amwa-224	270	2	b	b	PROPN
amwa-224	270	3	,	,	PUNCT
amwa-224	270	4	gerber	gerber	PROPN
amwa-224	270	5	hp	hp	PROPN
amwa-224	270	6	,	,	PUNCT
amwa-224	270	7	sapra	sapra	ADJ
amwa-224	270	8	p.	p.	NOUN
amwa-224	270	9	preclinical	preclinical	ADJ
amwa-224	270	10	and	and	CCONJ
amwa-224	270	11	clinical	clinical	ADJ
amwa-224	270	12	development	development	NOUN
amwa-224	270	13	of	of	ADP
amwa-224	270	14	inotuzumab	inotuzumab	NOUN
amwa-224	270	15	-	-	PUNCT
amwa-224	270	16	ozogamicin	ozogamicin	NOUN
amwa-224	270	17	in	in	ADP
amwa-224	270	18	hematological	hematological	ADJ
amwa-224	270	19	malignancies	malignancy	NOUN
amwa-224	270	20	.	.	PUNCT
amwa-224	271	1	mol	mol	ADP
amwa-224	271	2	immunol	immunol	NOUN
amwa-224	271	3	.	.	PUNCT
amwa-224	272	1	2015;67(2	2015;67(2	NUM
amwa-224	272	2	pt	pt	INTJ
amwa-224	272	3	a):107	a):107	NOUN
amwa-224	272	4	-	-	PUNCT
amwa-224	272	5	116	116	NUM
amwa-224	272	6	.	.	PUNCT
amwa-224	272	7	doi:10.1016	doi:10.1016	PROPN
amwa-224	272	8	/	/	SYM
amwa-224	272	9	j.	j.	PROPN
amwa-224	272	10	molimm.2014.09.014	molimm.2014.09.014	PROPN
amwa-224	272	11	59	59	NUM
amwa-224	272	12	.	.	PUNCT
amwa-224	273	1	walker	walker	PROPN
amwa-224	273	2	s	s	PROPN
amwa-224	273	3	,	,	PUNCT
amwa-224	273	4	landovitz	landovitz	PROPN
amwa-224	273	5	r	r	NOUN
amwa-224	273	6	,	,	PUNCT
amwa-224	273	7	ding	de	VERB
amwa-224	273	8	wd	wd	PROPN
amwa-224	273	9	,	,	PUNCT
amwa-224	273	10	ellestad	ellestad	PROPN
amwa-224	273	11	ga	ga	PROPN
amwa-224	273	12	,	,	PUNCT
amwa-224	273	13	kahne	kahne	PROPN
amwa-224	273	14	d.	d.	PROPN
amwa-224	273	15	cleavage	cleavage	NOUN
amwa-224	273	16	behavior	behavior	NOUN
amwa-224	273	17	of	of	ADP
amwa-224	273	18	calicheamicin	calicheamicin	NOUN
amwa-224	273	19	gamma	gamma	NOUN
amwa-224	273	20	1	1	NUM
amwa-224	273	21	and	and	CCONJ
amwa-224	273	22	calicheamicin	calicheamicin	NOUN
amwa-224	273	23	t.	t.	PROPN
amwa-224	273	24	proc	proc	PROPN
amwa-224	273	25	natl	natl	PROPN
amwa-224	273	26	acad	acad	PROPN
amwa-224	273	27	sci	sci	PROPN
amwa-224	273	28	usa	usa	PROPN
amwa-224	273	29	.	.	PROPN
amwa-224	274	1	1992;89(10):4608	1992;89(10):4608	NUM
amwa-224	274	2	-	-	PUNCT
amwa-224	274	3	4612	4612	NUM
amwa-224	274	4	.	.	PUNCT
amwa-224	275	1	doi:10.1073/	doi:10.1073/	PROPN
amwa-224	275	2	pnas.89.10.4608	pnas.89.10.4608	NOUN
amwa-224	275	3	60	60	NUM
amwa-224	275	4	.	.	PUNCT
amwa-224	276	1	elmroth	elmroth	PROPN
amwa-224	276	2	k	k	PROPN
amwa-224	276	3	,	,	PUNCT
amwa-224	276	4	nygren	nygren	PROPN
amwa-224	276	5	j	j	PROPN
amwa-224	276	6	,	,	PUNCT
amwa-224	276	7	mårtensson	mårtensson	PROPN
amwa-224	276	8	s	s	PROPN
amwa-224	276	9	,	,	PUNCT
amwa-224	276	10	ismail	ismail	PROPN
amwa-224	276	11	ih	ih	NOUN
amwa-224	276	12	,	,	PUNCT
amwa-224	276	13	hammarsten	hammarsten	VERB
amwa-224	276	14	o.	o.	NOUN
amwa-224	276	15	cleavage	cleavage	NOUN
amwa-224	276	16	of	of	ADP
amwa-224	276	17	cellular	cellular	ADJ
amwa-224	276	18	dna	dna	NOUN
amwa-224	276	19	by	by	ADP
amwa-224	276	20	calicheamicin	calicheamicin	NOUN
amwa-224	276	21	gamma1	gamma1	PROPN
amwa-224	276	22	.	.	PUNCT
amwa-224	277	1	dna	dna	PROPN
amwa-224	277	2	repair	repair	PROPN
amwa-224	277	3	(	(	PUNCT
amwa-224	277	4	amst	amst	NOUN
amwa-224	277	5	)	)	PUNCT
amwa-224	277	6	.	.	PUNCT
amwa-224	278	1	2003;2(4):363	2003;2(4):363	X
amwa-224	278	2	-	-	SYM
amwa-224	278	3	374	374	NUM
amwa-224	278	4	.	.	PUNCT
amwa-224	278	5	doi:10.1016	doi:10.1016	PROPN
amwa-224	278	6	/	/	SYM
amwa-224	278	7	s1568	s1568	PROPN
amwa-224	278	8	-	-	PUNCT
amwa-224	278	9	7864(02)00235	7864(02)00235	NUM
amwa-224	278	10	-	-	SYM
amwa-224	278	11	5	5	NUM
amwa-224	278	12	61	61	NUM
amwa-224	278	13	.	.	PUNCT
amwa-224	279	1	yao	yao	PROPN
amwa-224	279	2	hp	hp	PROPN
amwa-224	279	3	,	,	PUNCT
amwa-224	279	4	zhao	zhao	PROPN
amwa-224	279	5	h	h	NOUN
amwa-224	279	6	,	,	PUNCT
amwa-224	279	7	hudson	hudson	PROPN
amwa-224	279	8	r	r	PROPN
amwa-224	279	9	,	,	PUNCT
amwa-224	279	10	tong	tong	PROPN
amwa-224	279	11	xm	xm	PROPN
amwa-224	279	12	,	,	PUNCT
amwa-224	279	13	wang	wang	PROPN
amwa-224	279	14	mh	mh	PROPN
amwa-224	279	15	.	.	PROPN
amwa-224	279	16	duocarmycinbased	duocarmycinbase	VERB
amwa-224	279	17	antibody	antibody	NOUN
amwa-224	279	18	-	-	PUNCT
amwa-224	279	19	drug	drug	NOUN
amwa-224	279	20	conjugates	conjugate	NOUN
amwa-224	279	21	as	as	ADP
amwa-224	279	22	an	an	DET
amwa-224	279	23	emerging	emerge	VERB
amwa-224	279	24	biotherapeutic	biotherapeutic	ADJ
amwa-224	279	25	entity	entity	NOUN
amwa-224	279	26	for	for	ADP
amwa-224	279	27	targeted	target	VERB
amwa-224	279	28	cancer	cancer	NOUN
amwa-224	279	29	therapy	therapy	NOUN
amwa-224	279	30	:	:	PUNCT
amwa-224	279	31	pharmaceutical	pharmaceutical	NOUN
amwa-224	279	32	strategy	strategy	NOUN
amwa-224	279	33	and	and	CCONJ
amwa-224	279	34	clinical	clinical	ADJ
amwa-224	279	35	progress	progress	NOUN
amwa-224	279	36	.	.	PUNCT
amwa-224	280	1	drug	drug	NOUN
amwa-224	280	2	discov	discov	PROPN
amwa-224	280	3	today	today	NOUN
amwa-224	280	4	.	.	PUNCT
amwa-224	281	1	2021;26(8):1857	2021;26(8):1857	PROPN
amwa-224	281	2	-	-	SYM
amwa-224	281	3	1874	1874	NUM
amwa-224	281	4	.	.	PUNCT
amwa-224	282	1	doi:10.1016	doi:10.1016	PROPN
amwa-224	282	2	/	/	SYM
amwa-224	282	3	j.drudis.2021.06.012	j.drudis.2021.06.012	PROPN
amwa-224	282	4	62	62	NUM
amwa-224	282	5	.	.	PUNCT
amwa-224	283	1	hanka	hanka	PROPN
amwa-224	283	2	lj	lj	PROPN
amwa-224	283	3	,	,	PUNCT
amwa-224	283	4	dietz	dietz	PROPN
amwa-224	283	5	a	a	PROPN
amwa-224	283	6	,	,	PUNCT
amwa-224	283	7	gerpheide	gerpheide	PROPN
amwa-224	283	8	sa	sa	PROPN
amwa-224	283	9	,	,	PUNCT
amwa-224	283	10	kuentzel	kuentzel	PROPN
amwa-224	283	11	sl	sl	PROPN
amwa-224	283	12	,	,	PUNCT
amwa-224	283	13	martin	martin	PROPN
amwa-224	283	14	dg	dg	PROPN
amwa-224	283	15	.	.	PUNCT
amwa-224	284	1	cc-1065	cc-1065	PROPN
amwa-224	284	2	(	(	PUNCT
amwa-224	284	3	nsc-298223	nsc-298223	PROPN
amwa-224	284	4	)	)	PUNCT
amwa-224	284	5	,	,	PUNCT
amwa-224	284	6	a	a	DET
amwa-224	284	7	new	new	ADJ
amwa-224	284	8	antitumor	antitumor	PROPN
amwa-224	284	9	antibiotic	antibiotic	NOUN
amwa-224	284	10	.	.	PUNCT
amwa-224	285	1	production	production	NOUN
amwa-224	285	2	,	,	PUNCT
amwa-224	285	3	in	in	ADP
amwa-224	285	4	vitro	vitro	X
amwa-224	285	5	biological	biological	ADJ
amwa-224	285	6	activity	activity	NOUN
amwa-224	285	7	,	,	PUNCT
amwa-224	285	8	microbiological	microbiological	ADJ
amwa-224	285	9	assays	assay	NOUN
amwa-224	285	10	and	and	CCONJ
amwa-224	285	11	taxonomy	taxonomy	NOUN
amwa-224	285	12	of	of	ADP
amwa-224	285	13	the	the	DET
amwa-224	285	14	producing	produce	VERB
amwa-224	285	15	microorganism	microorganism	NOUN
amwa-224	285	16	.	.	PUNCT
amwa-224	286	1	j	j	PROPN
amwa-224	286	2	antibiot	antibiot	PROPN
amwa-224	286	3	(	(	PUNCT
amwa-224	286	4	tokyo	tokyo	PROPN
amwa-224	286	5	)	)	PUNCT
amwa-224	286	6	.	.	PUNCT
amwa-224	287	1	1978;31(12):1211	1978;31(12):1211	NUM
amwa-224	287	2	-	-	SYM
amwa-224	287	3	1217	1217	NUM
amwa-224	287	4	.	.	PUNCT
amwa-224	288	1	doi:10.7164	doi:10.7164	NOUN
amwa-224	288	2	/	/	SYM
amwa-224	288	3	antibiotics.31.1211	antibiotics.31.1211	PROPN
amwa-224	288	4	63	63	NUM
amwa-224	288	5	.	.	PUNCT
amwa-224	289	1	menderes	mendere	NOUN
amwa-224	289	2	g	g	PROPN
amwa-224	289	3	,	,	PUNCT
amwa-224	289	4	bonazzoli	bonazzoli	NOUN
amwa-224	289	5	e	e	NOUN
amwa-224	289	6	,	,	PUNCT
amwa-224	289	7	bellone	bellone	NOUN
amwa-224	289	8	s	s	PROPN
amwa-224	289	9	,	,	PUNCT
amwa-224	289	10	et	et	PROPN
amwa-224	289	11	al	al	PROPN
amwa-224	289	12	.	.	PUNCT
amwa-224	290	1	syd985	syd985	PROPN
amwa-224	290	2	,	,	PUNCT
amwa-224	290	3	a	a	DET
amwa-224	290	4	novel	novel	NOUN
amwa-224	290	5	duocarmycin	duocarmycin	NOUN
amwa-224	290	6	-	-	PUNCT
amwa-224	290	7	based	base	VERB
amwa-224	290	8	her2	her2	PROPN
amwa-224	290	9	-	-	PUNCT
amwa-224	290	10	targeting	target	VERB
amwa-224	290	11	antibody	antibody	NOUN
amwa-224	290	12	-	-	PUNCT
amwa-224	290	13	drug	drug	NOUN
amwa-224	290	14	conjugate	conjugate	NOUN
amwa-224	290	15	,	,	PUNCT
amwa-224	290	16	shows	show	VERB
amwa-224	290	17	promising	promise	VERB
amwa-224	290	18	antitumor	antitumor	NOUN
amwa-224	290	19	activity	activity	NOUN
amwa-224	290	20	in	in	ADP
amwa-224	290	21	epithelial	epithelial	ADJ
amwa-224	290	22	ovarian	ovarian	ADJ
amwa-224	290	23	carcinoma	carcinoma	NOUN
amwa-224	290	24	with	with	ADP
amwa-224	290	25	her2	her2	PROPN
amwa-224	290	26	/	/	SYM
amwa-224	290	27	neu	neu	NOUN
amwa-224	290	28	expression	expression	NOUN
amwa-224	290	29	.	.	PUNCT
amwa-224	291	1	gynecol	gynecol	ADJ
amwa-224	291	2	oncol	oncol	ADJ
amwa-224	291	3	.	.	PUNCT
amwa-224	292	1	2017;146(1):179	2017;146(1):179	NUM
amwa-224	292	2	-	-	SYM
amwa-224	292	3	186	186	NUM
amwa-224	292	4	.	.	PUNCT
amwa-224	292	5	doi	doi	NOUN
amwa-224	292	6	:	:	PUNCT
amwa-224	292	7	10.1016	10.1016	NUM
amwa-224	292	8	/	/	SYM
amwa-224	292	9	j.ygyno.2017.04.023	j.ygyno.2017.04.023	PROPN
amwa-224	292	10	.	.	PROPN
amwa-224	293	1	64	64	NUM
amwa-224	293	2	.	.	PUNCT
amwa-224	294	1	boger	boger	PROPN
amwa-224	294	2	dl	dl	PROPN
amwa-224	294	3	.	.	PUNCT
amwa-224	295	1	the	the	DET
amwa-224	295	2	duocarmycins	duocarmycin	NOUN
amwa-224	295	3	:	:	PUNCT
amwa-224	295	4	synthetic	synthetic	ADJ
amwa-224	295	5	and	and	CCONJ
amwa-224	295	6	mechanistic	mechanistic	ADJ
amwa-224	295	7	studies	study	NOUN
amwa-224	295	8	.	.	PUNCT
amwa-224	296	1	acc	acc	PROPN
amwa-224	296	2	chem	chem	NOUN
amwa-224	296	3	res	re	NOUN
amwa-224	296	4	.	.	PUNCT
amwa-224	297	1	1995;28(1):20	1995;28(1):20	NUM
amwa-224	297	2	-	-	SYM
amwa-224	297	3	29	29	NUM
amwa-224	297	4	.	.	PUNCT
amwa-224	298	1	doi:10.1021	doi:10.1021	ADJ
amwa-224	298	2	/	/	SYM
amwa-224	298	3	ar00049a004	ar00049a004	VERB
amwa-224	298	4	65	65	NUM
amwa-224	298	5	.	.	PUNCT
amwa-224	299	1	gerratana	gerratana	PROPN
amwa-224	299	2	b.	b.	PROPN
amwa-224	299	3	biosynthesis	biosynthesis	NOUN
amwa-224	299	4	,	,	PUNCT
amwa-224	299	5	synthesis	synthesis	NOUN
amwa-224	299	6	,	,	PUNCT
amwa-224	299	7	and	and	CCONJ
amwa-224	299	8	biological	biological	ADJ
amwa-224	299	9	activities	activity	NOUN
amwa-224	299	10	of	of	ADP
amwa-224	299	11	pyrrolobenzodiazepines	pyrrolobenzodiazepine	NOUN
amwa-224	299	12	.	.	PUNCT
amwa-224	300	1	med	med	ADJ
amwa-224	300	2	res	re	NOUN
amwa-224	300	3	rev	rev	PROPN
amwa-224	300	4	.	.	PROPN
amwa-224	301	1	2012;32(2):254	2012;32(2):254	NUM
amwa-224	301	2	-	-	SYM
amwa-224	301	3	293	293	NUM
amwa-224	301	4	.	.	PUNCT
amwa-224	302	1	doi:10.1002	doi:10.1002	NOUN
amwa-224	302	2	/	/	SYM
amwa-224	302	3	med.20212	med.20212	PROPN
amwa-224	302	4	66	66	NUM
amwa-224	302	5	.	.	PUNCT
amwa-224	303	1	tiberghien	tiberghien	PROPN
amwa-224	303	2	ac	ac	PROPN
amwa-224	303	3	,	,	PUNCT
amwa-224	303	4	levy	levy	PROPN
amwa-224	303	5	jn	jn	PROPN
amwa-224	303	6	,	,	PUNCT
amwa-224	303	7	masterson	masterson	PROPN
amwa-224	303	8	la	la	PROPN
amwa-224	303	9	,	,	PUNCT
amwa-224	303	10	et	et	PROPN
amwa-224	303	11	al	al	PROPN
amwa-224	303	12	.	.	PROPN
amwa-224	303	13	design	design	NOUN
amwa-224	303	14	and	and	CCONJ
amwa-224	303	15	synthesis	synthesis	NOUN
amwa-224	303	16	of	of	ADP
amwa-224	303	17	tesirine	tesirine	NOUN
amwa-224	303	18	,	,	PUNCT
amwa-224	303	19	a	a	DET
amwa-224	303	20	clinical	clinical	ADJ
amwa-224	303	21	antibody	antibody	NOUN
amwa-224	303	22	-	-	PUNCT
amwa-224	303	23	drug	drug	NOUN
amwa-224	303	24	conjugate	conjugate	ADJ
amwa-224	303	25	pyrrolobenzodiazepine	pyrrolobenzodiazepine	NOUN
amwa-224	303	26	dimer	dimer	PROPN
amwa-224	303	27	payload	payload	NOUN
amwa-224	303	28	.	.	PUNCT
amwa-224	304	1	acs	acs	PROPN
amwa-224	304	2	med	med	PROPN
amwa-224	304	3	chem	chem	PROPN
amwa-224	304	4	lett	lett	PROPN
amwa-224	304	5	.	.	PUNCT
amwa-224	305	1	2016;7(11):983	2016;7(11):983	NUM
amwa-224	305	2	-	-	SYM
amwa-224	305	3	987	987	NUM
amwa-224	305	4	.	.	PUNCT
amwa-224	306	1	doi	doi	NOUN
amwa-224	306	2	:	:	PUNCT
amwa-224	306	3	10.1021	10.1021	NUM
amwa-224	306	4	/	/	SYM
amwa-224	306	5	acsmedchemlett.6b00062	acsmedchemlett.6b00062	PROPN
amwa-224	306	6	.	.	PUNCT
amwa-224	307	1	67	67	NUM
amwa-224	307	2	.	.	PUNCT
amwa-224	308	1	tendler	tendler	PROPN
amwa-224	308	2	md	md	PROPN
amwa-224	308	3	,	,	PUNCT
amwa-224	308	4	korman	korman	PROPN
amwa-224	308	5	s.	s.	PROPN
amwa-224	308	6	'	'	PART
amwa-224	308	7	refuin	refuin	PROPN
amwa-224	308	8	'	'	PUNCT
amwa-224	308	9	:	:	PUNCT
amwa-224	308	10	a	a	DET
amwa-224	308	11	non	non	ADJ
amwa-224	308	12	-	-	ADJ
amwa-224	308	13	cytotoxic	cytotoxic	ADJ
amwa-224	308	14	carcinostatic	carcinostatic	ADJ
amwa-224	308	15	compound	compound	NOUN
amwa-224	308	16	proliferated	proliferate	VERB
amwa-224	308	17	by	by	ADP
amwa-224	308	18	a	a	DET
amwa-224	308	19	thermophilic	thermophilic	ADJ
amwa-224	308	20	actinomycete	actinomycete	NOUN
amwa-224	308	21	.	.	PUNCT
amwa-224	309	1	nature	nature	NOUN
amwa-224	309	2	.	.	PUNCT
amwa-224	310	1	1963;199:501	1963;199:501	X
amwa-224	310	2	.	.	PUNCT
amwa-224	311	1	doi:10.1038/199501a0	doi:10.1038/199501a0	NOUN
amwa-224	311	2	68	68	NUM
amwa-224	311	3	.	.	PUNCT
amwa-224	312	1	leimgruber	leimgruber	PROPN
amwa-224	312	2	w	w	PROPN
amwa-224	312	3	,	,	PUNCT
amwa-224	312	4	stefanović	stefanović	PROPN
amwa-224	312	5	v	v	NOUN
amwa-224	312	6	,	,	PUNCT
amwa-224	312	7	schenker	schenker	PROPN
amwa-224	312	8	f	f	PROPN
amwa-224	312	9	,	,	PUNCT
amwa-224	312	10	karr	karr	PROPN
amwa-224	312	11	a	a	PROPN
amwa-224	312	12	,	,	PUNCT
amwa-224	312	13	berger	berger	PROPN
amwa-224	312	14	j.	j.	PROPN
amwa-224	312	15	isolation	isolation	PROPN
amwa-224	312	16	and	and	CCONJ
amwa-224	312	17	characterization	characterization	NOUN
amwa-224	312	18	of	of	ADP
amwa-224	312	19	anthramycin	anthramycin	PROPN
amwa-224	312	20	,	,	PUNCT
amwa-224	312	21	a	a	DET
amwa-224	312	22	new	new	ADJ
amwa-224	312	23	antitumor	antitumor	PROPN
amwa-224	312	24	antibiotic	antibiotic	NOUN
amwa-224	312	25	.	.	PUNCT
amwa-224	313	1	j	j	PROPN
amwa-224	313	2	am	be	AUX
amwa-224	313	3	chem	chem	NOUN
amwa-224	313	4	soc	soc	NOUN
amwa-224	313	5	.	.	PUNCT
amwa-224	314	1	1965;87(24):5791	1965;87(24):5791	NUM
amwa-224	314	2	-	-	SYM
amwa-224	314	3	5793	5793	NUM
amwa-224	314	4	.	.	PUNCT
amwa-224	315	1	doi:10.1021	doi:10.1021	PROPN
amwa-224	315	2	/	/	SYM
amwa-224	315	3	ja00952a050	ja00952a050	PROPN
amwa-224	315	4	69	69	NUM
amwa-224	315	5	.	.	PUNCT
amwa-224	316	1	hartley	hartley	PROPN
amwa-224	316	2	ja	ja	PROPN
amwa-224	316	3	,	,	PUNCT
amwa-224	316	4	flynn	flynn	PROPN
amwa-224	316	5	mj	mj	PROPN
amwa-224	316	6	,	,	PUNCT
amwa-224	316	7	bingham	bingham	PROPN
amwa-224	316	8	jp	jp	PROPN
amwa-224	316	9	,	,	PUNCT
amwa-224	316	10	et	et	PROPN
amwa-224	316	11	al	al	PROPN
amwa-224	316	12	.	.	PUNCT
amwa-224	317	1	pre	pre	ADJ
amwa-224	317	2	-	-	ADJ
amwa-224	317	3	clinical	clinical	ADJ
amwa-224	317	4	pharmacology	pharmacology	NOUN
amwa-224	317	5	and	and	CCONJ
amwa-224	317	6	mechanism	mechanism	NOUN
amwa-224	317	7	of	of	ADP
amwa-224	317	8	action	action	NOUN
amwa-224	317	9	of	of	ADP
amwa-224	317	10	sg3199	sg3199	PROPN
amwa-224	317	11	,	,	PUNCT
amwa-224	317	12	the	the	DET
amwa-224	317	13	pyrrolobenzodiazepine	pyrrolobenzodiazepine	NOUN
amwa-224	317	14	(	(	PUNCT
amwa-224	317	15	pbd	pbd	PROPN
amwa-224	317	16	)	)	PUNCT
amwa-224	317	17	dimer	dimer	NOUN
amwa-224	317	18	warhead	warhead	NOUN
amwa-224	317	19	component	component	NOUN
amwa-224	317	20	of	of	ADP
amwa-224	317	21	antibody	antibody	NOUN
amwa-224	317	22	-	-	PUNCT
amwa-224	317	23	drug	drug	NOUN
amwa-224	317	24	conjugate	conjugate	NOUN
amwa-224	317	25	(	(	PUNCT
amwa-224	317	26	adc	adc	NOUN
amwa-224	317	27	)	)	PUNCT
amwa-224	317	28	payload	payload	NOUN
amwa-224	317	29	tesirine	tesirine	NOUN
amwa-224	317	30	.	.	PUNCT
amwa-224	318	1	sci	sci	PROPN
amwa-224	318	2	rep	rep	PROPN
amwa-224	318	3	.	.	PROPN
amwa-224	318	4	2018;8(1):10479	2018;8(1):10479	NUM
amwa-224	318	5	.	.	PUNCT
amwa-224	319	1	doi:10.1038/	doi:10.1038/	NUM
amwa-224	319	2	s41598	s41598	PROPN
amwa-224	319	3	-	-	PUNCT
amwa-224	319	4	018	018	NUM
amwa-224	319	5	-	-	PUNCT
amwa-224	319	6	28533	28533	NUM
amwa-224	319	7	-	-	SYM
amwa-224	319	8	4	4	NUM
amwa-224	319	9	70	70	NUM
amwa-224	319	10	.	.	PUNCT
amwa-224	320	1	caimi	caimi	PROPN
amwa-224	320	2	pf	pf	PROPN
amwa-224	320	3	,	,	PUNCT
amwa-224	320	4	ai	ai	VERB
amwa-224	320	5	w	w	PROPN
amwa-224	320	6	,	,	PUNCT
amwa-224	320	7	alderuccio	alderuccio	PROPN
amwa-224	320	8	jp	jp	PROPN
amwa-224	320	9	,	,	PUNCT
amwa-224	320	10	et	et	PROPN
amwa-224	320	11	al	al	PROPN
amwa-224	320	12	.	.	PROPN
amwa-224	320	13	loncastuximab	loncastuximab	NOUN
amwa-224	320	14	tesirine	tesirine	NOUN
amwa-224	320	15	in	in	ADP
amwa-224	320	16	relapsed	relapse	VERB
amwa-224	320	17	or	or	CCONJ
amwa-224	320	18	refractory	refractory	NOUN
amwa-224	320	19	diffuse	diffuse	VERB
amwa-224	320	20	large	large	ADJ
amwa-224	320	21	b	b	NUM
amwa-224	320	22	-	-	PUNCT
amwa-224	320	23	cell	cell	NOUN
amwa-224	320	24	lymphoma	lymphoma	NOUN
amwa-224	320	25	(	(	PUNCT
amwa-224	320	26	lotis-2	lotis-2	PROPN
amwa-224	320	27	):	):	PUNCT
amwa-224	320	28	a	a	DET
amwa-224	320	29	multicentre	multicentre	NOUN
amwa-224	320	30	,	,	PUNCT
amwa-224	320	31	open	open	ADJ
amwa-224	320	32	-	-	PUNCT
amwa-224	320	33	label	label	NOUN
amwa-224	320	34	,	,	PUNCT
amwa-224	320	35	single	single	ADJ
amwa-224	320	36	-	-	PUNCT
amwa-224	320	37	arm	arm	NOUN
amwa-224	320	38	,	,	PUNCT
amwa-224	320	39	phase	phase	NOUN
amwa-224	320	40	2	2	NUM
amwa-224	320	41	trial	trial	NOUN
amwa-224	320	42	.	.	PUNCT
amwa-224	321	1	lancet	lancet	PROPN
amwa-224	321	2	oncol	oncol	PROPN
amwa-224	321	3	.	.	PUNCT
amwa-224	322	1	2021;22(6):790	2021;22(6):790	NUM
amwa-224	322	2	-	-	SYM
amwa-224	322	3	800	800	NUM
amwa-224	322	4	.	.	PUNCT
amwa-224	323	1	doi:10.1016	doi:10.1016	PROPN
amwa-224	323	2	/	/	SYM
amwa-224	323	3	s1470	s1470	PROPN
amwa-224	323	4	-	-	PUNCT
amwa-224	323	5	2045(21)00139	2045(21)00139	NUM
amwa-224	323	6	-	-	PUNCT
amwa-224	323	7	x	x	SYM
amwa-224	323	8	71	71	NUM
amwa-224	323	9	.	.	PUNCT
amwa-224	324	1	wall	wall	PROPN
amwa-224	324	2	me	i	PRON
amwa-224	324	3	,	,	PUNCT
amwa-224	324	4	wani	wani	PROPN
amwa-224	324	5	mc	mc	PROPN
amwa-224	324	6	,	,	PUNCT
amwa-224	324	7	cook	cook	PROPN
amwa-224	324	8	ce	ce	PROPN
amwa-224	324	9	,	,	PUNCT
amwa-224	324	10	palmer	palmer	PROPN
amwa-224	324	11	kh	kh	PROPN
amwa-224	324	12	,	,	PUNCT
amwa-224	324	13	mcphail	mcphail	VERB
amwa-224	324	14	at	at	ADP
amwa-224	324	15	,	,	PUNCT
amwa-224	324	16	sim	sim	PROPN
amwa-224	324	17	ga	ga	PROPN
amwa-224	324	18	.	.	PROPN
amwa-224	324	19	plant	plant	PROPN
amwa-224	324	20	antitumor	antitumor	PROPN
amwa-224	324	21	agents	agent	NOUN
amwa-224	324	22	.	.	PUNCT
amwa-224	325	1	i.	i.	PROPN
amwa-224	325	2	the	the	DET
amwa-224	325	3	isolation	isolation	NOUN
amwa-224	325	4	and	and	CCONJ
amwa-224	325	5	structure	structure	NOUN
amwa-224	325	6	of	of	ADP
amwa-224	325	7	camptothecin	camptothecin	PROPN
amwa-224	325	8	,	,	PUNCT
amwa-224	325	9	a	a	DET
amwa-224	325	10	novel	novel	ADJ
amwa-224	325	11	alkaloidal	alkaloidal	ADJ
amwa-224	325	12	leukemia	leukemia	NOUN
amwa-224	325	13	and	and	CCONJ
amwa-224	325	14	tumor	tumor	NOUN
amwa-224	325	15	inhibitor	inhibitor	NOUN
amwa-224	325	16	from	from	ADP
amwa-224	325	17	camptotheca	camptotheca	NOUN
amwa-224	325	18	acuminata	acuminata	PROPN
amwa-224	325	19	1,2	1,2	NUM
amwa-224	325	20	.	.	PUNCT
amwa-224	326	1	j	j	PROPN
amwa-224	326	2	am	be	AUX
amwa-224	326	3	chem	chem	NOUN
amwa-224	326	4	soc	soc	NOUN
amwa-224	326	5	.	.	PUNCT
amwa-224	327	1	1966;88(16):3888	1966;88(16):3888	X
amwa-224	327	2	-	-	SYM
amwa-224	327	3	3890	3890	NUM
amwa-224	327	4	.	.	PUNCT
amwa-224	328	1	doi:10.1021	doi:10.1021	ADJ
amwa-224	328	2	/	/	SYM
amwa-224	328	3	ja00968a057	ja00968a057	ADJ
amwa-224	328	4	72	72	NUM
amwa-224	328	5	.	.	PUNCT
amwa-224	329	1	li	li	PROPN
amwa-224	329	2	w	w	PROPN
amwa-224	329	3	,	,	PUNCT
amwa-224	329	4	veale	veale	PROPN
amwa-224	329	5	kh	kh	PROPN
amwa-224	329	6	,	,	PUNCT
amwa-224	329	7	qiu	qiu	PROPN
amwa-224	329	8	q	q	NOUN
amwa-224	329	9	,	,	PUNCT
amwa-224	329	10	et	et	PROPN
amwa-224	329	11	al	al	PROPN
amwa-224	329	12	.	.	PUNCT
amwa-224	329	13	synthesis	synthesis	NOUN
amwa-224	329	14	and	and	CCONJ
amwa-224	329	15	evaluation	evaluation	NOUN
amwa-224	329	16	of	of	ADP
amwa-224	329	17	camptothecin	camptothecin	NOUN
amwa-224	329	18	antibody	antibody	NOUN
amwa-224	329	19	-	-	PUNCT
amwa-224	329	20	drug	drug	NOUN
amwa-224	329	21	conjugates	conjugate	NOUN
amwa-224	329	22	.	.	PUNCT
amwa-224	330	1	acs	acs	PROPN
amwa-224	330	2	med	med	PROPN
amwa-224	330	3	chem	chem	PROPN
amwa-224	330	4	lett	lett	PROPN
amwa-224	330	5	.	.	PUNCT
amwa-224	331	1	2019;10(10):1386	2019;10(10):1386	NUM
amwa-224	331	2	-	-	SYM
amwa-224	331	3	1392	1392	NUM
amwa-224	331	4	.	.	PUNCT
amwa-224	332	1	doi:10.1021	doi:10.1021	PROPN
amwa-224	332	2	/	/	SYM
amwa-224	332	3	acsmedchemlett.9b00301	acsmedchemlett.9b00301	PROPN
amwa-224	332	4	73	73	NUM
amwa-224	332	5	.	.	PUNCT
amwa-224	333	1	hsiang	hsiang	PROPN
amwa-224	333	2	yh	yh	PROPN
amwa-224	333	3	,	,	PUNCT
amwa-224	333	4	hertzberg	hertzberg	PROPN
amwa-224	333	5	r	r	PROPN
amwa-224	333	6	,	,	PUNCT
amwa-224	333	7	hecht	hecht	PROPN
amwa-224	333	8	s	s	PROPN
amwa-224	333	9	,	,	PUNCT
amwa-224	333	10	liu	liu	PROPN
amwa-224	333	11	lf	lf	PROPN
amwa-224	333	12	.	.	PUNCT
amwa-224	333	13	camptothecin	camptothecin	PROPN
amwa-224	333	14	induces	induce	VERB
amwa-224	333	15	protein	protein	NOUN
amwa-224	333	16	-	-	PUNCT
amwa-224	333	17	linked	link	VERB
amwa-224	333	18	dna	dna	PROPN
amwa-224	333	19	breaks	break	NOUN
amwa-224	333	20	via	via	ADP
amwa-224	333	21	mammalian	mammalian	ADJ
amwa-224	333	22	dna	dna	PROPN
amwa-224	334	1	topoisomerase	topoisomerase	PROPN
amwa-224	334	2	i.	i.	PROPN
amwa-224	334	3	j	j	PROPN
amwa-224	334	4	biol	biol	PROPN
amwa-224	334	5	chem	chem	NOUN
amwa-224	334	6	.	.	PUNCT
amwa-224	335	1	1985;260(27):14873	1985;260(27):14873	NUM
amwa-224	335	2	-	-	SYM
amwa-224	335	3	14878	14878	NUM
amwa-224	335	4	.	.	PUNCT
amwa-224	336	1	doi:10.1016	doi:10.1016	PROPN
amwa-224	336	2	/	/	SYM
amwa-224	336	3	s00219258(17)38654	s00219258(17)38654	PROPN
amwa-224	336	4	-	-	PUNCT
amwa-224	336	5	4	4	NUM
amwa-224	336	6	74	74	NUM
amwa-224	336	7	.	.	PUNCT
amwa-224	337	1	ogitani	ogitani	PROPN
amwa-224	337	2	y	y	PROPN
amwa-224	337	3	,	,	PUNCT
amwa-224	337	4	aida	aida	PROPN
amwa-224	337	5	t	t	PROPN
amwa-224	337	6	,	,	PUNCT
amwa-224	337	7	hagihara	hagihara	PROPN
amwa-224	337	8	k	k	PROPN
amwa-224	337	9	,	,	PUNCT
amwa-224	337	10	et	et	PROPN
amwa-224	337	11	al	al	PROPN
amwa-224	337	12	.	.	PROPN
amwa-224	337	13	ds-8201a	ds-8201a	PROPN
amwa-224	337	14	,	,	PUNCT
amwa-224	337	15	a	a	DET
amwa-224	337	16	novel	novel	NOUN
amwa-224	337	17	her2targeting	her2targete	VERB
amwa-224	337	18	adc	adc	NOUN
amwa-224	337	19	with	with	ADP
amwa-224	337	20	a	a	DET
amwa-224	337	21	novel	novel	ADJ
amwa-224	337	22	dna	dna	NOUN
amwa-224	337	23	topoisomerase	topoisomerase	NOUN
amwa-224	337	24	i	i	PRON
amwa-224	337	25	inhibitor	inhibitor	NOUN
amwa-224	337	26	,	,	PUNCT
amwa-224	337	27	demonstrates	demonstrate	VERB
amwa-224	337	28	a	a	DET
amwa-224	337	29	promising	promising	ADJ
amwa-224	337	30	antitumor	antitumor	PROPN
amwa-224	337	31	efficacy	efficacy	NOUN
amwa-224	337	32	with	with	ADP
amwa-224	337	33	differentiation	differentiation	NOUN
amwa-224	337	34	from	from	ADP
amwa-224	337	35	t	t	PROPN
amwa-224	337	36	-	-	PUNCT
amwa-224	337	37	dm1	dm1	PROPN
amwa-224	337	38	.	.	PUNCT
amwa-224	338	1	clin	clin	PROPN
amwa-224	338	2	cancer	cancer	NOUN
amwa-224	338	3	res	re	NOUN
amwa-224	338	4	.	.	PUNCT
amwa-224	339	1	2016;22(20):5097	2016;22(20):5097	NUM
amwa-224	339	2	-	-	SYM
amwa-224	339	3	5108	5108	NUM
amwa-224	339	4	.	.	PUNCT
amwa-224	340	1	doi:10.1158/1078	doi:10.1158/1078	ADV
amwa-224	340	2	-	-	PUNCT
amwa-224	340	3	0432.ccr-15	0432.ccr-15	NUM
amwa-224	340	4	-	-	SYM
amwa-224	340	5	2822	2822	NUM
amwa-224	340	6	75	75	NUM
amwa-224	340	7	.	.	PUNCT
amwa-224	341	1	goldenberg	goldenberg	PROPN
amwa-224	341	2	dm	dm	PROPN
amwa-224	341	3	,	,	PUNCT
amwa-224	341	4	sharkey	sharkey	PROPN
amwa-224	341	5	rm	rm	PROPN
amwa-224	341	6	.	.	PUNCT
amwa-224	342	1	antibody	antibody	NOUN
amwa-224	342	2	-	-	PUNCT
amwa-224	342	3	drug	drug	NOUN
amwa-224	342	4	conjugates	conjugate	NOUN
amwa-224	342	5	targeting	target	VERB
amwa-224	342	6	trop-2	trop-2	NOUN
amwa-224	342	7	and	and	CCONJ
amwa-224	342	8	incorporating	incorporate	VERB
amwa-224	342	9	sn-38	sn-38	NOUN
amwa-224	342	10	:	:	PUNCT
amwa-224	342	11	a	a	DET
amwa-224	342	12	case	case	NOUN
amwa-224	342	13	study	study	NOUN
amwa-224	342	14	of	of	ADP
amwa-224	342	15	anti	anti	ADJ
amwa-224	342	16	-	-	ADJ
amwa-224	342	17	trop-2	trop-2	PRON
amwa-224	342	18	sacituzumab	sacituzumab	NOUN
amwa-224	342	19	govitecan	govitecan	PROPN
amwa-224	342	20	.	.	PUNCT
amwa-224	342	21	mabs	mabs	PROPN
amwa-224	342	22	.	.	PUNCT
amwa-224	343	1	2019;11(6):987	2019;11(6):987	NUM
amwa-224	343	2	-	-	SYM
amwa-224	343	3	995	995	NUM
amwa-224	343	4	.	.	PUNCT
amwa-224	344	1	doi:10.1080/19	doi:10.1080/19	X
amwa-224	344	2	420862.2019.1632115	420862.2019.1632115	NUM
amwa-224	344	3	76	76	NUM
amwa-224	344	4	.	.	PUNCT
amwa-224	345	1	senter	senter	PROPN
amwa-224	345	2	pd	pd	PROPN
amwa-224	345	3	,	,	PUNCT
amwa-224	345	4	sievers	sievers	PROPN
amwa-224	345	5	el	el	PROPN
amwa-224	345	6	.	.	PUNCT
amwa-224	346	1	the	the	DET
amwa-224	346	2	discovery	discovery	NOUN
amwa-224	346	3	and	and	CCONJ
amwa-224	346	4	development	development	NOUN
amwa-224	346	5	of	of	ADP
amwa-224	346	6	brentuximab	brentuximab	NOUN
amwa-224	346	7	vedotin	vedotin	ADV
amwa-224	346	8	for	for	ADP
amwa-224	346	9	use	use	NOUN
amwa-224	346	10	in	in	ADP
amwa-224	346	11	relapsed	relapse	VERB
amwa-224	346	12	hodgkin	hodgkin	ADJ
amwa-224	346	13	lymphoma	lymphoma	NOUN
amwa-224	346	14	and	and	CCONJ
amwa-224	346	15	systemic	systemic	ADJ
amwa-224	346	16	anaplastic	anaplastic	ADJ
amwa-224	346	17	large	large	ADJ
amwa-224	346	18	cell	cell	NOUN
amwa-224	346	19	lymphoma	lymphoma	NOUN
amwa-224	346	20	.	.	PUNCT
amwa-224	347	1	nat	nat	PROPN
amwa-224	347	2	biotechnol	biotechnol	NOUN
amwa-224	347	3	.	.	PUNCT
amwa-224	348	1	2012;30(7):631	2012;30(7):631	NUM
amwa-224	348	2	-	-	PUNCT
amwa-224	348	3	637	637	NUM
amwa-224	348	4	.	.	PUNCT
amwa-224	349	1	doi:10.1038	doi:10.1038	NOUN
amwa-224	349	2	/	/	SYM
amwa-224	349	3	nbt.2289	nbt.2289	NUM
amwa-224	349	4	77	77	NUM
amwa-224	349	5	.	.	PUNCT
amwa-224	350	1	pettit	pettit	PROPN
amwa-224	350	2	gr	gr	PROPN
amwa-224	350	3	,	,	PUNCT
amwa-224	350	4	kamano	kamano	ADJ
amwa-224	350	5	y	y	PROPN
amwa-224	350	6	,	,	PUNCT
amwa-224	350	7	herald	herald	PROPN
amwa-224	350	8	cl	cl	PROPN
amwa-224	350	9	,	,	PUNCT
amwa-224	350	10	et	et	PROPN
amwa-224	350	11	al	al	PROPN
amwa-224	350	12	.	.	PUNCT
amwa-224	351	1	the	the	DET
amwa-224	351	2	isolation	isolation	NOUN
amwa-224	351	3	and	and	CCONJ
amwa-224	351	4	structure	structure	NOUN
amwa-224	351	5	of	of	ADP
amwa-224	351	6	a	a	DET
amwa-224	351	7	remarkable	remarkable	ADJ
amwa-224	351	8	marine	marine	ADJ
amwa-224	351	9	animal	animal	NOUN
amwa-224	351	10	antineoplastic	antineoplastic	ADJ
amwa-224	351	11	constituent	constituent	NOUN
amwa-224	351	12	:	:	PUNCT
amwa-224	351	13	dolastatin	dolastatin	NOUN
amwa-224	351	14	10	10	NUM
amwa-224	351	15	.	.	PUNCT
amwa-224	352	1	j	j	PROPN
amwa-224	352	2	am	be	AUX
amwa-224	352	3	chem	chem	NOUN
amwa-224	352	4	soc	soc	NOUN
amwa-224	352	5	.	.	PUNCT
amwa-224	353	1	1987;109(22):6883	1987;109(22):6883	NUM
amwa-224	353	2	-	-	SYM
amwa-224	353	3	6885	6885	NUM
amwa-224	353	4	.	.	PUNCT
amwa-224	354	1	doi:10.1021	doi:10.1021	ADJ
amwa-224	354	2	/	/	SYM
amwa-224	354	3	ja00256a070	ja00256a070	PROPN
amwa-224	354	4	78	78	NUM
amwa-224	354	5	.	.	PUNCT
amwa-224	355	1	bai	bai	PROPN
amwa-224	355	2	r	r	PROPN
amwa-224	355	3	,	,	PUNCT
amwa-224	355	4	pettit	pettit	PROPN
amwa-224	355	5	gr	gr	PROPN
amwa-224	355	6	,	,	PUNCT
amwa-224	355	7	hamel	hamel	PROPN
amwa-224	355	8	e.	e.	PROPN
amwa-224	355	9	dolastatin	dolastatin	PROPN
amwa-224	355	10	10	10	NUM
amwa-224	355	11	,	,	PUNCT
amwa-224	355	12	a	a	DET
amwa-224	355	13	powerful	powerful	ADJ
amwa-224	355	14	cytostatic	cytostatic	ADJ
amwa-224	355	15	peptide	peptide	NOUN
amwa-224	355	16	derived	derive	VERB
amwa-224	355	17	from	from	ADP
amwa-224	355	18	a	a	DET
amwa-224	355	19	marine	marine	ADJ
amwa-224	355	20	animal	animal	NOUN
amwa-224	355	21	.	.	PUNCT
amwa-224	356	1	inhibition	inhibition	NOUN
amwa-224	356	2	of	of	ADP
amwa-224	356	3	tubulin	tubulin	NOUN
amwa-224	356	4	polymerization	polymerization	NOUN
amwa-224	356	5	mediated	mediate	VERB
amwa-224	356	6	through	through	ADP
amwa-224	356	7	the	the	DET
amwa-224	356	8	vinca	vinca	NOUN
amwa-224	356	9	alkaloid	alkaloid	NOUN
amwa-224	356	10	binding	bind	VERB
amwa-224	356	11	domain	domain	NOUN
amwa-224	356	12	.	.	PUNCT
amwa-224	357	1	biochem	biochem	PROPN
amwa-224	357	2	pharmacol	pharmacol	PROPN
amwa-224	357	3	.	.	PUNCT
amwa-224	358	1	1990;39(12):1941	1990;39(12):1941	NUM
amwa-224	358	2	-	-	SYM
amwa-224	358	3	1949	1949	NUM
amwa-224	358	4	.	.	PUNCT
amwa-224	359	1	doi:10.1016/0006	doi:10.1016/0006	ADJ
amwa-224	359	2	-	-	PUNCT
amwa-224	359	3	2952(90)90613	2952(90)90613	NUM
amwa-224	359	4	-	-	PUNCT
amwa-224	359	5	p	p	NOUN
amwa-224	359	6	79	79	NUM
amwa-224	359	7	.	.	PUNCT
amwa-224	360	1	bai	bai	PROPN
amwa-224	360	2	rl	rl	PROPN
amwa-224	360	3	,	,	PUNCT
amwa-224	360	4	pettit	pettit	PROPN
amwa-224	360	5	gr	gr	PROPN
amwa-224	360	6	,	,	PUNCT
amwa-224	360	7	hamel	hamel	PROPN
amwa-224	360	8	e.	e.	PROPN
amwa-224	360	9	structure	structure	PROPN
amwa-224	360	10	-	-	PUNCT
amwa-224	360	11	activity	activity	NOUN
amwa-224	360	12	studies	study	NOUN
amwa-224	360	13	with	with	ADP
amwa-224	360	14	chiral	chiral	ADJ
amwa-224	360	15	isomers	isomer	NOUN
amwa-224	360	16	and	and	CCONJ
amwa-224	360	17	with	with	ADP
amwa-224	360	18	segments	segment	NOUN
amwa-224	360	19	of	of	ADP
amwa-224	360	20	the	the	DET
amwa-224	360	21	antimitotic	antimitotic	ADJ
amwa-224	360	22	marine	marine	ADJ
amwa-224	360	23	peptide	peptide	NOUN
amwa-224	360	24	dolastatin	dolastatin	NOUN
amwa-224	360	25	10	10	NUM
amwa-224	360	26	.	.	PUNCT
amwa-224	361	1	biochem	biochem	PROPN
amwa-224	361	2	pharmacol	pharmacol	PROPN
amwa-224	361	3	.	.	PUNCT
amwa-224	362	1	1990;40(8):1859	1990;40(8):1859	NUM
amwa-224	362	2	-	-	PUNCT
amwa-224	362	3	1864	1864	NUM
amwa-224	362	4	.	.	PUNCT
amwa-224	363	1	doi:10.1016/0006	doi:10.1016/0006	NOUN
amwa-224	363	2	-	-	PUNCT
amwa-224	363	3	2952(90)90367	2952(90)90367	NUM
amwa-224	363	4	-	-	PUNCT
amwa-224	363	5	t	t	PROPN
amwa-224	363	6	80	80	NUM
amwa-224	363	7	.	.	PUNCT
amwa-224	364	1	waight	waight	PROPN
amwa-224	364	2	ab	ab	PROPN
amwa-224	364	3	,	,	PUNCT
amwa-224	364	4	bargsten	bargsten	VERB
amwa-224	364	5	k	k	PROPN
amwa-224	364	6	,	,	PUNCT
amwa-224	364	7	doronina	doronina	VERB
amwa-224	364	8	s	s	PROPN
amwa-224	364	9	,	,	PUNCT
amwa-224	364	10	steinmetz	steinmetz	PROPN
amwa-224	364	11	mo	mo	PROPN
amwa-224	364	12	,	,	PUNCT
amwa-224	364	13	sussman	sussman	PROPN
amwa-224	364	14	d	d	PROPN
amwa-224	364	15	,	,	PUNCT
amwa-224	364	16	prota	prota	PROPN
amwa-224	364	17	ae	ae	PROPN
amwa-224	364	18	.	.	PUNCT
amwa-224	365	1	structural	structural	ADJ
amwa-224	365	2	basis	basis	NOUN
amwa-224	365	3	of	of	ADP
amwa-224	365	4	microtubule	microtubule	NOUN
amwa-224	365	5	destabilization	destabilization	NOUN
amwa-224	365	6	by	by	ADP
amwa-224	365	7	potent	potent	ADJ
amwa-224	365	8	auristatin	auristatin	ADJ
amwa-224	365	9	anti	anti	NOUN
amwa-224	365	10	-	-	NOUN
amwa-224	365	11	mitotics	mitotic	NOUN
amwa-224	365	12	.	.	PUNCT
amwa-224	366	1	plos	plos	PROPN
amwa-224	366	2	one	one	NUM
amwa-224	366	3	.	.	PUNCT
amwa-224	367	1	2016;11(8):e0160890	2016;11(8):e0160890	NUM
amwa-224	367	2	.	.	PUNCT
amwa-224	367	3	doi	doi	NOUN
amwa-224	367	4	:	:	PUNCT
amwa-224	367	5	10.1371	10.1371	NUM
amwa-224	367	6	/	/	SYM
amwa-224	367	7	journal.pone.0160890	journal.pone.0160890	NOUN
amwa-224	367	8	.	.	PROPN
amwa-224	367	9	81	81	NUM
amwa-224	367	10	.	.	PUNCT
amwa-224	368	1	kupchan	kupchan	PROPN
amwa-224	368	2	sm	sm	PROPN
amwa-224	368	3	,	,	PUNCT
amwa-224	368	4	komoda	komoda	PROPN
amwa-224	368	5	y	y	PROPN
amwa-224	368	6	,	,	PUNCT
amwa-224	368	7	branfman	branfman	PROPN
amwa-224	368	8	ar	ar	PROPN
amwa-224	368	9	,	,	PUNCT
amwa-224	368	10	et	et	PROPN
amwa-224	368	11	al	al	PROPN
amwa-224	368	12	.	.	PUNCT
amwa-224	369	1	the	the	DET
amwa-224	369	2	maytansinoids	maytansinoids	PROPN
amwa-224	369	3	.	.	PUNCT
amwa-224	370	1	isolation	isolation	NOUN
amwa-224	370	2	,	,	PUNCT
amwa-224	370	3	structural	structural	ADJ
amwa-224	370	4	elucidation	elucidation	NOUN
amwa-224	370	5	,	,	PUNCT
amwa-224	370	6	and	and	CCONJ
amwa-224	370	7	chemical	chemical	NOUN
amwa-224	370	8	interrelation	interrelation	NOUN
amwa-224	370	9	of	of	ADP
amwa-224	370	10	novel	novel	ADJ
amwa-224	370	11	ansa	ansa	NOUN
amwa-224	370	12	macrolides	macrolide	NOUN
amwa-224	370	13	.	.	PUNCT
amwa-224	371	1	j	j	PROPN
amwa-224	371	2	org	org	PROPN
amwa-224	371	3	chem	chem	NOUN
amwa-224	371	4	.	.	PUNCT
amwa-224	372	1	1977;42(14):2349	1977;42(14):2349	NUM
amwa-224	372	2	-	-	SYM
amwa-224	372	3	2357	2357	NUM
amwa-224	372	4	.	.	PUNCT
amwa-224	373	1	doi:10.1021	doi:10.1021	PROPN
amwa-224	373	2	/	/	SYM
amwa-224	373	3	jo00434a001	jo00434a001	PROPN
amwa-224	373	4	82	82	NUM
amwa-224	373	5	.	.	PUNCT
amwa-224	374	1	lambert	lambert	PROPN
amwa-224	374	2	jm	jm	PROPN
amwa-224	374	3	,	,	PUNCT
amwa-224	374	4	chari	chari	PROPN
amwa-224	374	5	rv	rv	PROPN
amwa-224	374	6	.	.	PUNCT
amwa-224	374	7	ado	ado	NOUN
amwa-224	374	8	-	-	PUNCT
amwa-224	374	9	trastuzumab	trastuzumab	NOUN
amwa-224	374	10	emtansine	emtansine	NOUN
amwa-224	374	11	(	(	PUNCT
amwa-224	374	12	t	t	PROPN
amwa-224	374	13	-	-	PUNCT
amwa-224	374	14	dm1	dm1	PROPN
amwa-224	374	15	):	):	PUNCT
amwa-224	374	16	an	an	DET
amwa-224	374	17	http://www.amwajournal.org	http://www.amwajournal.org	X
amwa-224	374	18	amwajournal.org	amwajournal.org	X
amwa-224	374	19	35antibody	35antibody	NUM
amwa-224	374	20	-	-	PUNCT
amwa-224	374	21	drug	drug	NOUN
amwa-224	374	22	conjugates	conjugate	NOUN
amwa-224	374	23	antibody	antibody	NOUN
amwa-224	374	24	-	-	PUNCT
amwa-224	374	25	drug	drug	NOUN
amwa-224	374	26	conjugate	conjugate	NOUN
amwa-224	374	27	(	(	PUNCT
amwa-224	374	28	adc	adc	PROPN
amwa-224	374	29	)	)	PUNCT
amwa-224	374	30	for	for	ADP
amwa-224	374	31	her2	her2	NOUN
amwa-224	374	32	-	-	PUNCT
amwa-224	374	33	positive	positive	ADJ
amwa-224	374	34	breast	breast	NOUN
amwa-224	374	35	cancer	cancer	NOUN
amwa-224	374	36	.	.	PUNCT
amwa-224	375	1	j	j	PROPN
amwa-224	375	2	med	med	PROPN
amwa-224	375	3	chem	chem	NOUN
amwa-224	375	4	.	.	PUNCT
amwa-224	376	1	2014;57(16):6949	2014;57(16):6949	X
amwa-224	376	2	-	-	SYM
amwa-224	376	3	6964	6964	NUM
amwa-224	376	4	.	.	PUNCT
amwa-224	377	1	doi:10.1021	doi:10.1021	PROPN
amwa-224	377	2	/	/	SYM
amwa-224	377	3	jm500766w	jm500766w	PROPN
amwa-224	377	4	83	83	NUM
amwa-224	377	5	.	.	PUNCT
amwa-224	378	1	chen	chen	PROPN
amwa-224	378	2	h	h	PROPN
amwa-224	378	3	,	,	PUNCT
amwa-224	378	4	lin	lin	PROPN
amwa-224	378	5	z	z	PROPN
amwa-224	378	6	,	,	PUNCT
amwa-224	378	7	arnst	arnst	ADP
amwa-224	378	8	ke	ke	PROPN
amwa-224	378	9	,	,	PUNCT
amwa-224	378	10	miller	miller	PROPN
amwa-224	378	11	dd	dd	PROPN
amwa-224	378	12	,	,	PUNCT
amwa-224	378	13	li	li	PROPN
amwa-224	378	14	w.	w.	PROPN
amwa-224	378	15	tubulin	tubulin	PROPN
amwa-224	378	16	inhibitor	inhibitor	NOUN
amwa-224	378	17	-	-	PUNCT
amwa-224	378	18	based	base	VERB
amwa-224	378	19	antibody	antibody	NOUN
amwa-224	378	20	-	-	PUNCT
amwa-224	378	21	drug	drug	NOUN
amwa-224	378	22	conjugates	conjugate	NOUN
amwa-224	378	23	for	for	ADP
amwa-224	378	24	cancer	cancer	NOUN
amwa-224	378	25	therapy	therapy	NOUN
amwa-224	378	26	.	.	PUNCT
amwa-224	379	1	molecules	molecule	NOUN
amwa-224	379	2	.	.	PUNCT
amwa-224	380	1	2017	2017	NUM
amwa-224	380	2	aug	aug	PROPN
amwa-224	380	3	1;22(8):1281	1;22(8):1281	NUM
amwa-224	380	4	.	.	PUNCT
amwa-224	381	1	doi	doi	NOUN
amwa-224	381	2	:	:	PUNCT
amwa-224	381	3	10.3390	10.3390	NUM
amwa-224	381	4	/	/	SYM
amwa-224	381	5	molecules22081281	molecules22081281	PROPN
amwa-224	381	6	.	.	PUNCT
amwa-224	382	1	pmid	pmid	NOUN
amwa-224	382	2	:	:	PUNCT
amwa-224	382	3	28763044	28763044	NUM
amwa-224	382	4	;	;	PUNCT
amwa-224	382	5	pmcid	pmcid	PROPN
amwa-224	382	6	:	:	PUNCT
amwa-224	382	7	pmc6152078	pmc6152078	ADJ
amwa-224	382	8	.	.	PUNCT
amwa-224	383	1	84	84	NUM
amwa-224	383	2	.	.	PUNCT
amwa-224	384	1	pegram	pegram	PROPN
amwa-224	384	2	md	md	PROPN
amwa-224	384	3	,	,	PUNCT
amwa-224	384	4	hamilton	hamilton	PROPN
amwa-224	384	5	ep	ep	PROPN
amwa-224	384	6	,	,	PUNCT
amwa-224	384	7	tan	tan	PROPN
amwa-224	384	8	ar	ar	PROPN
amwa-224	384	9	,	,	PUNCT
amwa-224	384	10	et	et	PROPN
amwa-224	384	11	al	al	PROPN
amwa-224	384	12	.	.	PUNCT
amwa-224	385	1	first	first	ADJ
amwa-224	385	2	-	-	PUNCT
amwa-224	385	3	in	in	ADP
amwa-224	385	4	-	-	PUNCT
amwa-224	385	5	human	human	ADJ
amwa-224	385	6	,	,	PUNCT
amwa-224	385	7	phase	phase	NOUN
amwa-224	385	8	1	1	NUM
amwa-224	385	9	dose	dose	NOUN
amwa-224	385	10	-	-	PUNCT
amwa-224	385	11	escalation	escalation	NOUN
amwa-224	385	12	study	study	NOUN
amwa-224	385	13	of	of	ADP
amwa-224	385	14	biparatopic	biparatopic	ADJ
amwa-224	385	15	anti	anti	ADJ
amwa-224	385	16	-	-	ADJ
amwa-224	385	17	her2	her2	ADJ
amwa-224	385	18	antibody	antibody	NOUN
amwa-224	385	19	-	-	PUNCT
amwa-224	385	20	drug	drug	NOUN
amwa-224	385	21	conjugate	conjugate	ADJ
amwa-224	385	22	medi4276	medi4276	NOUN
amwa-224	385	23	in	in	ADP
amwa-224	385	24	patients	patient	NOUN
amwa-224	385	25	with	with	ADP
amwa-224	385	26	her2	her2	PROPN
amwa-224	385	27	-	-	PUNCT
amwa-224	385	28	positive	positive	ADJ
amwa-224	385	29	advanced	advanced	ADJ
amwa-224	385	30	breast	breast	NOUN
amwa-224	385	31	or	or	CCONJ
amwa-224	385	32	gastric	gastric	ADJ
amwa-224	385	33	cancer	cancer	NOUN
amwa-224	385	34	.	.	PUNCT
amwa-224	386	1	mol	mol	ADP
amwa-224	386	2	cancer	cancer	NOUN
amwa-224	386	3	ther	ther	ADV
amwa-224	386	4	.	.	PUNCT
amwa-224	387	1	2021;20(8):1442	2021;20(8):1442	NUM
amwa-224	387	2	-	-	SYM
amwa-224	387	3	1453	1453	NUM
amwa-224	387	4	.	.	PUNCT
amwa-224	388	1	doi:10.1158/1535	doi:10.1158/1535	NOUN
amwa-224	388	2	-	-	PUNCT
amwa-224	388	3	7163.mct-20	7163.mct-20	NUM
amwa-224	388	4	-	-	PUNCT
amwa-224	388	5	0014	0014	NUM
amwa-224	388	6	85	85	NUM
amwa-224	388	7	.	.	PUNCT
amwa-224	389	1	sasse	sasse	PROPN
amwa-224	389	2	f	f	PROPN
amwa-224	389	3	,	,	PUNCT
amwa-224	389	4	steinmetz	steinmetz	PROPN
amwa-224	389	5	h	h	PROPN
amwa-224	389	6	,	,	PUNCT
amwa-224	389	7	heil	heil	PROPN
amwa-224	389	8	j	j	PROPN
amwa-224	389	9	,	,	PUNCT
amwa-224	389	10	höfle	höfle	NOUN
amwa-224	389	11	g	g	PROPN
amwa-224	389	12	,	,	PUNCT
amwa-224	389	13	reichenbach	reichenbach	PROPN
amwa-224	389	14	h.	h.	PROPN
amwa-224	389	15	tubulysins	tubulysins	PROPN
amwa-224	389	16	,	,	PUNCT
amwa-224	389	17	new	new	ADJ
amwa-224	389	18	cytostatic	cytostatic	ADJ
amwa-224	389	19	peptides	peptide	NOUN
amwa-224	389	20	from	from	ADP
amwa-224	389	21	myxobacteria	myxobacteria	NOUN
amwa-224	389	22	acting	act	VERB
amwa-224	389	23	on	on	ADP
amwa-224	389	24	microtubuli	microtubuli	PROPN
amwa-224	389	25	.	.	PUNCT
amwa-224	390	1	production	production	NOUN
amwa-224	390	2	,	,	PUNCT
amwa-224	390	3	isolation	isolation	NOUN
amwa-224	390	4	,	,	PUNCT
amwa-224	390	5	physico	physico	NOUN
amwa-224	390	6	-	-	PUNCT
amwa-224	390	7	chemical	chemical	ADJ
amwa-224	390	8	and	and	CCONJ
amwa-224	390	9	biological	biological	ADJ
amwa-224	390	10	properties	property	NOUN
amwa-224	390	11	.	.	PUNCT
amwa-224	391	1	j	j	PROPN
amwa-224	391	2	antibiot	antibiot	PROPN
amwa-224	391	3	(	(	PUNCT
amwa-224	391	4	tokyo	tokyo	PROPN
amwa-224	391	5	)	)	PUNCT
amwa-224	391	6	.	.	PUNCT
amwa-224	392	1	2000;53(9):879	2000;53(9):879	NUM
amwa-224	392	2	-	-	PUNCT
amwa-224	392	3	885	885	NUM
amwa-224	392	4	.	.	PUNCT
amwa-224	393	1	doi:10.7164/	doi:10.7164/	PROPN
amwa-224	393	2	antibiotics.53.879	antibiotics.53.879	VERB
amwa-224	393	3	86	86	NUM
amwa-224	393	4	.	.	PUNCT
amwa-224	394	1	peters	peters	PROPN
amwa-224	394	2	s	s	PROPN
amwa-224	394	3	,	,	PUNCT
amwa-224	394	4	mok	mok	PROPN
amwa-224	394	5	t	t	PROPN
amwa-224	394	6	,	,	PUNCT
amwa-224	394	7	passaro	passaro	VERB
amwa-224	394	8	a	a	PRON
amwa-224	394	9	,	,	PUNCT
amwa-224	394	10	jänne	jänne	PROPN
amwa-224	394	11	pa	pa	PROPN
amwa-224	394	12	.	.	PUNCT
amwa-224	395	1	the	the	DET
amwa-224	395	2	promising	promising	ADJ
amwa-224	395	3	evolution	evolution	NOUN
amwa-224	395	4	of	of	ADP
amwa-224	395	5	targeted	target	VERB
amwa-224	395	6	therapeutic	therapeutic	ADJ
amwa-224	395	7	strategies	strategy	NOUN
amwa-224	395	8	in	in	ADP
amwa-224	395	9	cancer	cancer	NOUN
amwa-224	395	10	.	.	PUNCT
amwa-224	396	1	cancer	cancer	NOUN
amwa-224	396	2	discov	discov	NOUN
amwa-224	396	3	.	.	PUNCT
amwa-224	397	1	2021;11(4):810	2021;11(4):810	NUM
amwa-224	397	2	-	-	SYM
amwa-224	397	3	814	814	NUM
amwa-224	397	4	.	.	PUNCT
amwa-224	398	1	doi:10.1158/2159	doi:10.1158/2159	NOUN
amwa-224	398	2	-	-	PUNCT
amwa-224	398	3	8290.cd-21	8290.cd-21	NUM
amwa-224	398	4	-	-	PUNCT
amwa-224	398	5	0124	0124	NUM
amwa-224	398	6	87	87	NUM
amwa-224	398	7	.	.	PUNCT
amwa-224	399	1	el	el	NOUN
amwa-224	399	2	-	-	PUNCT
amwa-224	399	3	deiry	deiry	PROPN
amwa-224	399	4	ws	ws	NOUN
amwa-224	399	5	,	,	PUNCT
amwa-224	399	6	goldberg	goldberg	PROPN
amwa-224	399	7	rm	rm	PROPN
amwa-224	399	8	,	,	PUNCT
amwa-224	399	9	lenz	lenz	PROPN
amwa-224	399	10	hj	hj	PROPN
amwa-224	399	11	,	,	PUNCT
amwa-224	399	12	et	et	PROPN
amwa-224	399	13	al	al	PROPN
amwa-224	399	14	.	.	PUNCT
amwa-224	400	1	the	the	DET
amwa-224	400	2	current	current	ADJ
amwa-224	400	3	state	state	NOUN
amwa-224	400	4	of	of	ADP
amwa-224	400	5	molecular	molecular	ADJ
amwa-224	400	6	testing	testing	NOUN
amwa-224	400	7	in	in	ADP
amwa-224	400	8	the	the	DET
amwa-224	400	9	treatment	treatment	NOUN
amwa-224	400	10	of	of	ADP
amwa-224	400	11	patients	patient	NOUN
amwa-224	400	12	with	with	ADP
amwa-224	400	13	solid	solid	ADJ
amwa-224	400	14	tumors	tumor	NOUN
amwa-224	400	15	,	,	PUNCT
amwa-224	400	16	2019	2019	NUM
amwa-224	400	17	.	.	PUNCT
amwa-224	401	1	ca	can	AUX
amwa-224	401	2	cancer	cancer	PROPN
amwa-224	401	3	j	j	PROPN
amwa-224	401	4	clin	clin	PROPN
amwa-224	401	5	.	.	PUNCT
amwa-224	402	1	2019;69(4):305	2019;69(4):305	NUM
amwa-224	402	2	-	-	SYM
amwa-224	402	3	343	343	NUM
amwa-224	402	4	.	.	PUNCT
amwa-224	403	1	doi:10.3322/	doi:10.3322/	NOUN
amwa-224	404	1	caac.21560	caac.21560	ADV
amwa-224	404	2	88	88	NUM
amwa-224	404	3	.	.	PUNCT
amwa-224	405	1	seebacher	seebacher	PROPN
amwa-224	405	2	na	na	PROPN
amwa-224	405	3	,	,	PUNCT
amwa-224	405	4	stacy	stacy	PROPN
amwa-224	405	5	ae	ae	PROPN
amwa-224	405	6	,	,	PUNCT
amwa-224	405	7	porter	porter	PROPN
amwa-224	405	8	gm	gm	PROPN
amwa-224	405	9	,	,	PUNCT
amwa-224	405	10	merlot	merlot	NOUN
amwa-224	405	11	am	be	AUX
amwa-224	405	12	.	.	PUNCT
amwa-224	406	1	clinical	clinical	ADJ
amwa-224	406	2	development	development	NOUN
amwa-224	406	3	of	of	ADP
amwa-224	406	4	targeted	target	VERB
amwa-224	406	5	and	and	CCONJ
amwa-224	406	6	immune	immune	ADJ
amwa-224	406	7	based	base	VERB
amwa-224	406	8	anti	anti	ADJ
amwa-224	406	9	-	-	ADJ
amwa-224	406	10	cancer	cancer	ADJ
amwa-224	406	11	therapies	therapy	NOUN
amwa-224	406	12	.	.	PUNCT
amwa-224	407	1	j	j	PROPN
amwa-224	407	2	exp	exp	PROPN
amwa-224	407	3	clin	clin	PROPN
amwa-224	407	4	cancer	cancer	NOUN
amwa-224	407	5	res	re	NOUN
amwa-224	407	6	.	.	PUNCT
amwa-224	408	1	2019;38(1):156	2019;38(1):156	NUM
amwa-224	408	2	.	.	PUNCT
amwa-224	409	1	doi:10.1186/	doi:10.1186/	PROPN
amwa-224	409	2	s13046	s13046	PROPN
amwa-224	409	3	-	-	PUNCT
amwa-224	409	4	019	019	NUM
amwa-224	409	5	-	-	PUNCT
amwa-224	409	6	1094	1094	NUM
amwa-224	409	7	-	-	SYM
amwa-224	409	8	2	2	NUM
amwa-224	409	9	89	89	NUM
amwa-224	409	10	.	.	PUNCT
amwa-224	410	1	vadas	vadas	PROPN
amwa-224	410	2	a	a	DET
amwa-224	410	3	,	,	PUNCT
amwa-224	410	4	bilodeau	bilodeau	PROPN
amwa-224	410	5	tj	tj	PROPN
amwa-224	410	6	,	,	PUNCT
amwa-224	410	7	oza	oza	PROPN
amwa-224	410	8	c.	c.	PROPN
amwa-224	411	1	the	the	DET
amwa-224	411	2	evolution	evolution	NOUN
amwa-224	411	3	of	of	ADP
amwa-224	411	4	biomarker	biomarker	NOUN
amwa-224	411	5	use	use	NOUN
amwa-224	411	6	in	in	ADP
amwa-224	411	7	clinical	clinical	ADJ
amwa-224	411	8	trials	trial	NOUN
amwa-224	411	9	for	for	ADP
amwa-224	411	10	cancer	cancer	NOUN
amwa-224	411	11	treatments	treatment	NOUN
amwa-224	411	12	.	.	PUNCT
amwa-224	412	1	pmc	pmc	PROPN
amwa-224	412	2	;	;	PUNCT
amwa-224	412	3	2019	2019	NUM
amwa-224	412	4	.	.	PUNCT
amwa-224	413	1	accessed	access	VERB
amwa-224	413	2	february	february	PROPN
amwa-224	413	3	7	7	NUM
amwa-224	413	4	,	,	PUNCT
amwa-224	413	5	2022	2022	NUM
amwa-224	413	6	.	.	PUNCT
amwa-224	414	1	http://www.personalizedmedicinecoalition	http://www.personalizedmedicinecoalition	NOUN
amwa-224	414	2	.	.	PUNCT
amwa-224	415	1	org	org	ADJ
amwa-224	415	2	/	/	SYM
amwa-224	415	3	userfiles	userfiles	ADJ
amwa-224	415	4	/	/	SYM
amwa-224	415	5	pmc	pmc	NOUN
amwa-224	415	6	-	-	PUNCT
amwa-224	415	7	corporate	corporate	ADJ
amwa-224	415	8	/	/	PUNCT
amwa-224	415	9	file	file	NOUN
amwa-224	415	10	/	/	SYM
amwa-224	415	11	the_evolution_of_biomarker	the_evolution_of_biomarker	NOUN
amwa-224	415	12	_	_	PUNCT
amwa-224	416	1	use_in_clinical_trials_for_cancer_treatments.pdf	use_in_clinical_trials_for_cancer_treatments.pdf	X
amwa-224	416	2	90	90	NUM
amwa-224	416	3	.	.	PUNCT
amwa-224	417	1	fda	fda	PROPN
amwa-224	417	2	approved	approve	VERB
amwa-224	417	3	antibody	antibody	NOUN
amwa-224	417	4	-	-	PUNCT
amwa-224	417	5	drug	drug	NOUN
amwa-224	417	6	conjugates	conjugate	NOUN
amwa-224	417	7	(	(	PUNCT
amwa-224	417	8	adcs	adcs	ADJ
amwa-224	417	9	)	)	PUNCT
amwa-224	417	10	up	up	ADP
amwa-224	417	11	to	to	ADP
amwa-224	417	12	2023	2023	NUM
amwa-224	417	13	.	.	PUNCT
amwa-224	418	1	biopharma	biopharma	NOUN
amwa-224	418	2	peg	peg	NOUN
amwa-224	418	3	.	.	PUNCT
amwa-224	419	1	published	publish	VERB
amwa-224	419	2	october	october	PROPN
amwa-224	419	3	30	30	NUM
amwa-224	419	4	,	,	PUNCT
amwa-224	419	5	2019	2019	NUM
amwa-224	419	6	.	.	PUNCT
amwa-224	420	1	accessed	access	VERB
amwa-224	420	2	february	february	PROPN
amwa-224	420	3	19	19	NUM
amwa-224	420	4	,	,	PUNCT
amwa-224	420	5	2023	2023	NUM
amwa-224	420	6	.	.	PUNCT
amwa-224	421	1	https://www.biochempeg.com/article/74.html	https://www.biochempeg.com/article/74.html	PROPN
amwa-224	421	2	91	91	NUM
amwa-224	421	3	.	.	PUNCT
amwa-224	422	1	destiny	destiny	NOUN
amwa-224	422	2	clinical	clinical	ADJ
amwa-224	422	3	trials	trial	NOUN
amwa-224	422	4	.	.	PUNCT
amwa-224	423	1	destinyclinicaltrials.com	destinyclinicaltrials.com	X
amwa-224	423	2	.	.	PUNCT
amwa-224	424	1	accessed	access	VERB
amwa-224	424	2	february	february	PROPN
amwa-224	424	3	19	19	NUM
amwa-224	424	4	,	,	PUNCT
amwa-224	424	5	2023	2023	NUM
amwa-224	424	6	.	.	PUNCT
amwa-224	425	1	https://www.destinyclinicaltrials.com/en	https://www.destinyclinicaltrials.com/en	PROPN
amwa-224	425	2	92	92	NUM
amwa-224	425	3	.	.	PUNCT
amwa-224	426	1	fda	fda	PROPN
amwa-224	426	2	grants	grant	VERB
amwa-224	426	3	regular	regular	ADJ
amwa-224	426	4	approval	approval	NOUN
amwa-224	426	5	to	to	ADP
amwa-224	426	6	fam	fam	NOUN
amwa-224	426	7	-	-	PUNCT
amwa-224	426	8	trastuzumab	trastuzumab	NOUN
amwa-224	426	9	deruxtecan	deruxtecan	ADJ
amwa-224	426	10	-	-	PUNCT
amwa-224	426	11	nxki	nxki	NOUN
amwa-224	426	12	for	for	ADP
amwa-224	426	13	breast	breast	NOUN
amwa-224	426	14	cancer	cancer	NOUN
amwa-224	426	15	.	.	PUNCT
amwa-224	427	1	us	us	PROPN
amwa-224	427	2	food	food	NOUN
amwa-224	427	3	and	and	CCONJ
amwa-224	427	4	drug	drug	PROPN
amwa-224	427	5	administration	administration	NOUN
amwa-224	427	6	.	.	PUNCT
amwa-224	428	1	published	publish	VERB
amwa-224	428	2	may	may	PROPN
amwa-224	428	3	11	11	NUM
amwa-224	428	4	,	,	PUNCT
amwa-224	428	5	2022	2022	NUM
amwa-224	428	6	.	.	PUNCT
amwa-224	429	1	accessed	access	VERB
amwa-224	429	2	february	february	PROPN
amwa-224	429	3	19	19	NUM
amwa-224	429	4	,	,	PUNCT
amwa-224	429	5	2023	2023	NUM
amwa-224	429	6	.	.	PUNCT
amwa-224	430	1	https://www.fda.gov/	https://www.fda.gov/	PROPN
amwa-224	430	2	drugs	drug	NOUN
amwa-224	430	3	/	/	SYM
amwa-224	430	4	resources	resource	NOUN
amwa-224	430	5	-	-	PUNCT
amwa-224	430	6	information	information	NOUN
amwa-224	430	7	-	-	PUNCT
amwa-224	430	8	approved	approve	VERB
amwa-224	430	9	-	-	PUNCT
amwa-224	430	10	drugs	drug	NOUN
amwa-224	430	11	/	/	SYM
amwa-224	430	12	fda	fda	PROPN
amwa-224	430	13	-	-	PUNCT
amwa-224	430	14	grants	grant	NOUN
amwa-224	430	15	-	-	PUNCT
amwa-224	430	16	regularapproval	regularapproval	NOUN
amwa-224	430	17	-	-	PUNCT
amwa-224	430	18	fam	fam	NOUN
amwa-224	430	19	-	-	PUNCT
amwa-224	430	20	trastuzumab	trastuzumab	NOUN
amwa-224	430	21	-	-	PUNCT
amwa-224	430	22	deruxtecan	deruxtecan	ADJ
amwa-224	430	23	-	-	PUNCT
amwa-224	430	24	nxki	nxki	ADJ
amwa-224	430	25	-	-	PUNCT
amwa-224	430	26	breast	breast	NOUN
amwa-224	430	27	-	-	PUNCT
amwa-224	430	28	cancer	cancer	NOUN
amwa-224	430	29	93	93	NUM
amwa-224	430	30	.	.	PUNCT
amwa-224	431	1	fda	fda	PROPN
amwa-224	431	2	approves	approve	VERB
amwa-224	431	3	fam	fam	NOUN
amwa-224	431	4	-	-	PUNCT
amwa-224	431	5	trastuzumab	trastuzumab	NOUN
amwa-224	431	6	deruxtecan	deruxtecan	ADJ
amwa-224	431	7	-	-	PUNCT
amwa-224	431	8	nxki	nxki	NOUN
amwa-224	431	9	for	for	ADP
amwa-224	431	10	her2positive	her2positive	PROPN
amwa-224	431	11	gastric	gastric	ADJ
amwa-224	431	12	adenocarcinomas	adenocarcinoma	NOUN
amwa-224	431	13	.	.	PUNCT
amwa-224	432	1	us	we	PRON
amwa-224	432	2	food	food	NOUN
amwa-224	432	3	and	and	CCONJ
amwa-224	432	4	drug	drug	PROPN
amwa-224	432	5	administration	administration	NOUN
amwa-224	432	6	.	.	PUNCT
amwa-224	433	1	published	publish	VERB
amwa-224	433	2	january	january	PROPN
amwa-224	433	3	15	15	NUM
amwa-224	433	4	,	,	PUNCT
amwa-224	433	5	2021	2021	NUM
amwa-224	433	6	.	.	PUNCT
amwa-224	434	1	accessed	access	VERB
amwa-224	434	2	february	february	PROPN
amwa-224	434	3	19	19	NUM
amwa-224	434	4	,	,	PUNCT
amwa-224	434	5	2023	2023	NUM
amwa-224	434	6	.	.	PUNCT
amwa-224	435	1	https://www.fda.gov/drugs/resources-informationapproved-drugs/fda-approves-fam-trastuzumab-deruxtecannxki-her2-positive-gastric-adenocarcinomas	https://www.fda.gov/drugs/resources-informationapproved-drugs/fda-approves-fam-trastuzumab-deruxtecannxki-her2-positive-gastric-adenocarcinoma	NOUN
amwa-224	435	2	94	94	NUM
amwa-224	435	3	.	.	PUNCT
amwa-224	436	1	fda	fda	PROPN
amwa-224	436	2	grants	grant	NOUN
amwa-224	436	3	accelerated	accelerate	VERB
amwa-224	436	4	approval	approval	NOUN
amwa-224	436	5	to	to	ADP
amwa-224	436	6	fam	fam	NOUN
amwa-224	436	7	-	-	PUNCT
amwa-224	436	8	trastuzumab	trastuzumab	NOUN
amwa-224	436	9	deruxtecan	deruxtecan	ADJ
amwa-224	436	10	-	-	PUNCT
amwa-224	436	11	nxki	nxki	NOUN
amwa-224	436	12	for	for	ADP
amwa-224	436	13	her2	her2	NOUN
amwa-224	436	14	-	-	PUNCT
amwa-224	436	15	mutant	mutant	ADJ
amwa-224	436	16	non	non	ADJ
amwa-224	436	17	-	-	ADJ
amwa-224	436	18	small	small	ADJ
amwa-224	436	19	cell	cell	NOUN
amwa-224	436	20	lung	lung	NOUN
amwa-224	436	21	cancer	cancer	NOUN
amwa-224	436	22	.	.	PUNCT
amwa-224	437	1	us	us	PROPN
amwa-224	437	2	food	food	NOUN
amwa-224	437	3	and	and	CCONJ
amwa-224	437	4	drug	drug	PROPN
amwa-224	437	5	administration	administration	NOUN
amwa-224	437	6	.	.	PUNCT
amwa-224	438	1	published	publish	VERB
amwa-224	438	2	august	august	PROPN
amwa-224	438	3	16	16	NUM
amwa-224	438	4	,	,	PUNCT
amwa-224	438	5	2022	2022	NUM
amwa-224	438	6	.	.	PUNCT
amwa-224	439	1	accessed	access	VERB
amwa-224	439	2	february	february	PROPN
amwa-224	439	3	19	19	NUM
amwa-224	439	4	,	,	PUNCT
amwa-224	439	5	2023	2023	NUM
amwa-224	439	6	.	.	PUNCT
amwa-224	440	1	https://www.fda.gov/drugs/	https://www.fda.gov/drugs/	X
amwa-224	440	2	resources	resource	NOUN
amwa-224	440	3	-	-	PUNCT
amwa-224	440	4	information	information	NOUN
amwa-224	440	5	-	-	PUNCT
amwa-224	440	6	approved	approve	VERB
amwa-224	440	7	-	-	PUNCT
amwa-224	440	8	drugs	drug	NOUN
amwa-224	440	9	/	/	SYM
amwa-224	440	10	fda	fda	PROPN
amwa-224	440	11	-	-	PUNCT
amwa-224	440	12	grants	grant	NOUN
amwa-224	440	13	-	-	PUNCT
amwa-224	440	14	acceleratedapproval	acceleratedapproval	ADJ
amwa-224	440	15	-	-	PUNCT
amwa-224	440	16	fam	fam	NOUN
amwa-224	440	17	-	-	PUNCT
amwa-224	440	18	trastuzumab	trastuzumab	NOUN
amwa-224	440	19	-	-	PUNCT
amwa-224	440	20	deruxtecan	deruxtecan	ADJ
amwa-224	440	21	-	-	PUNCT
amwa-224	440	22	nxki	nxki	NOUN
amwa-224	440	23	-	-	PUNCT
amwa-224	440	24	her2	her2	NOUN
amwa-224	440	25	-	-	PUNCT
amwa-224	440	26	mutant	mutant	NOUN
amwa-224	440	27	-	-	PUNCT
amwa-224	440	28	nonsmall	nonsmall	NOUN
amwa-224	440	29	-	-	PUNCT
amwa-224	440	30	cell	cell	NOUN
amwa-224	440	31	-	-	PUNCT
amwa-224	440	32	lung	lung	NOUN
amwa-224	440	33	95	95	NUM
amwa-224	440	34	.	.	PUNCT
amwa-224	441	1	fda	fda	PROPN
amwa-224	441	2	approves	approve	VERB
amwa-224	441	3	fam	fam	NOUN
amwa-224	441	4	-	-	PUNCT
amwa-224	441	5	trastuzumab	trastuzumab	NOUN
amwa-224	441	6	deruxtecan	deruxtecan	ADJ
amwa-224	441	7	-	-	PUNCT
amwa-224	441	8	nxki	nxki	NOUN
amwa-224	441	9	for	for	ADP
amwa-224	441	10	her2	her2	NOUN
amwa-224	441	11	-	-	PUNCT
amwa-224	441	12	low	low	ADJ
amwa-224	441	13	breast	breast	NOUN
amwa-224	441	14	cancer	cancer	NOUN
amwa-224	441	15	.	.	PUNCT
amwa-224	442	1	us	us	PROPN
amwa-224	442	2	food	food	NOUN
amwa-224	442	3	and	and	CCONJ
amwa-224	442	4	drug	drug	PROPN
amwa-224	442	5	administration	administration	NOUN
amwa-224	442	6	.	.	PUNCT
amwa-224	443	1	published	publish	VERB
amwa-224	443	2	august	august	PROPN
amwa-224	443	3	5	5	NUM
amwa-224	443	4	,	,	PUNCT
amwa-224	443	5	2022	2022	NUM
amwa-224	443	6	.	.	PUNCT
amwa-224	444	1	accessed	access	VERB
amwa-224	444	2	february	february	PROPN
amwa-224	444	3	19	19	NUM
amwa-224	444	4	,	,	PUNCT
amwa-224	444	5	2023	2023	NUM
amwa-224	444	6	.	.	PUNCT
amwa-224	445	1	https://www.fda.gov/	https://www.fda.gov/	PROPN
amwa-224	445	2	drugs	drug	NOUN
amwa-224	445	3	/	/	SYM
amwa-224	445	4	resources	resource	NOUN
amwa-224	445	5	-	-	PUNCT
amwa-224	445	6	information	information	NOUN
amwa-224	445	7	-	-	PUNCT
amwa-224	445	8	approved	approve	VERB
amwa-224	445	9	-	-	PUNCT
amwa-224	445	10	drugs	drug	NOUN
amwa-224	445	11	/	/	SYM
amwa-224	445	12	fda	fda	PROPN
amwa-224	445	13	-	-	PUNCT
amwa-224	445	14	approves	approves	PROPN
amwa-224	445	15	-	-	PUNCT
amwa-224	445	16	famtrastuzumab	famtrastuzumab	NOUN
amwa-224	445	17	-	-	PUNCT
amwa-224	445	18	deruxtecan	deruxtecan	ADJ
amwa-224	445	19	-	-	PUNCT
amwa-224	445	20	nxki	nxki	NOUN
amwa-224	445	21	-	-	PUNCT
amwa-224	445	22	her2	her2	NOUN
amwa-224	445	23	-	-	PUNCT
amwa-224	445	24	low	low	ADJ
amwa-224	445	25	-	-	PUNCT
amwa-224	445	26	breast	breast	NOUN
amwa-224	445	27	-	-	PUNCT
amwa-224	445	28	cancer	cancer	NOUN
amwa-224	445	29	96	96	NUM
amwa-224	445	30	.	.	PUNCT
amwa-224	446	1	eiger	eiger	PROPN
amwa-224	446	2	d	d	PROPN
amwa-224	446	3	,	,	PUNCT
amwa-224	446	4	agostinetto	agostinetto	PROPN
amwa-224	446	5	e	e	NOUN
amwa-224	446	6	,	,	PUNCT
amwa-224	446	7	saúde	saúde	NOUN
amwa-224	446	8	-	-	PUNCT
amwa-224	446	9	conde	conde	PROPN
amwa-224	446	10	r	r	NOUN
amwa-224	446	11	,	,	PUNCT
amwa-224	446	12	de	de	X
amwa-224	446	13	azambuja	azambuja	NOUN
amwa-224	446	14	e.	e.	PROPN
amwa-224	446	15	the	the	DET
amwa-224	446	16	exciting	exciting	ADJ
amwa-224	446	17	new	new	ADJ
amwa-224	446	18	field	field	NOUN
amwa-224	446	19	of	of	ADP
amwa-224	446	20	her2	her2	PROPN
amwa-224	446	21	-	-	PUNCT
amwa-224	446	22	low	low	ADJ
amwa-224	446	23	breast	breast	NOUN
amwa-224	446	24	cancer	cancer	NOUN
amwa-224	446	25	treatment	treatment	NOUN
amwa-224	446	26	.	.	PUNCT
amwa-224	447	1	cancers	cancer	NOUN
amwa-224	447	2	(	(	PUNCT
amwa-224	447	3	basel	basel	PROPN
amwa-224	447	4	)	)	PUNCT
amwa-224	447	5	.	.	PUNCT
amwa-224	448	1	2021;13(5):1015	2021;13(5):1015	NUM
amwa-224	448	2	.	.	PUNCT
amwa-224	449	1	doi:10.3390	doi:10.3390	PROPN
amwa-224	449	2	/	/	SYM
amwa-224	449	3	cancers13051015	cancers13051015	PROPN
amwa-224	449	4	97	97	NUM
amwa-224	449	5	.	.	PUNCT
amwa-224	450	1	modi	modi	PROPN
amwa-224	450	2	s	s	PART
amwa-224	450	3	,	,	PUNCT
amwa-224	450	4	jacot	jacot	PROPN
amwa-224	450	5	w	w	PROPN
amwa-224	450	6	,	,	PUNCT
amwa-224	450	7	yamashita	yamashita	PROPN
amwa-224	450	8	t	t	PROPN
amwa-224	450	9	,	,	PUNCT
amwa-224	450	10	et	et	PROPN
amwa-224	450	11	al	al	PROPN
amwa-224	450	12	.	.	PROPN
amwa-224	450	13	trastuzumab	trastuzumab	NOUN
amwa-224	450	14	deruxtecan	deruxtecan	NOUN
amwa-224	450	15	in	in	ADP
amwa-224	450	16	previously	previously	ADV
amwa-224	450	17	treated	treat	VERB
amwa-224	450	18	her2	her2	PROPN
amwa-224	450	19	-	-	PUNCT
amwa-224	450	20	low	low	ADJ
amwa-224	450	21	advanced	advanced	ADJ
amwa-224	450	22	breast	breast	NOUN
amwa-224	450	23	cancer	cancer	NOUN
amwa-224	450	24	.	.	PUNCT
amwa-224	451	1	n	n	PROPN
amwa-224	451	2	engl	engl	PROPN
amwa-224	451	3	j	j	PROPN
amwa-224	451	4	med	med	PROPN
amwa-224	451	5	.	.	PUNCT
amwa-224	452	1	2022;387(1):9	2022;387(1):9	NUM
amwa-224	452	2	-	-	SYM
amwa-224	452	3	20	20	NUM
amwa-224	452	4	.	.	PUNCT
amwa-224	452	5	doi:10.1056	doi:10.1056	PROPN
amwa-224	452	6	/	/	SYM
amwa-224	452	7	nejmoa2203690	nejmoa2203690	PROPN
amwa-224	452	8	98	98	NUM
amwa-224	452	9	.	.	PUNCT
amwa-224	453	1	abuhelwa	abuhelwa	SCONJ
amwa-224	453	2	z	z	X
amwa-224	453	3	,	,	PUNCT
amwa-224	453	4	alloghbi	alloghbi	PROPN
amwa-224	453	5	a	a	PRON
amwa-224	453	6	,	,	PUNCT
amwa-224	453	7	nagasaka	nagasaka	ADV
amwa-224	453	8	m.	m.	NOUN
amwa-224	453	9	a	a	DET
amwa-224	453	10	comprehensive	comprehensive	ADJ
amwa-224	453	11	review	review	NOUN
amwa-224	453	12	on	on	ADP
amwa-224	453	13	antibody	antibody	NOUN
amwa-224	453	14	-	-	PUNCT
amwa-224	453	15	drug	drug	NOUN
amwa-224	453	16	conjugates	conjugate	NOUN
amwa-224	453	17	(	(	PUNCT
amwa-224	453	18	adcs	adcs	ADV
amwa-224	453	19	)	)	PUNCT
amwa-224	453	20	in	in	ADP
amwa-224	453	21	the	the	DET
amwa-224	453	22	treatment	treatment	NOUN
amwa-224	453	23	landscape	landscape	NOUN
amwa-224	453	24	of	of	ADP
amwa-224	453	25	non	non	ADJ
amwa-224	453	26	-	-	ADJ
amwa-224	453	27	small	small	ADJ
amwa-224	453	28	cell	cell	NOUN
amwa-224	453	29	lung	lung	NOUN
amwa-224	453	30	cancer	cancer	NOUN
amwa-224	453	31	(	(	PUNCT
amwa-224	453	32	nsclc	nsclc	NOUN
amwa-224	453	33	)	)	PUNCT
amwa-224	453	34	.	.	PUNCT
amwa-224	454	1	cancer	cancer	NOUN
amwa-224	454	2	treat	treat	PROPN
amwa-224	454	3	rev	rev	VERB
amwa-224	454	4	.	.	PROPN
amwa-224	454	5	2022;106:102393	2022;106:102393	NUM
amwa-224	454	6	.	.	PUNCT
amwa-224	455	1	doi:10.1016	doi:10.1016	PROPN
amwa-224	455	2	/	/	SYM
amwa-224	455	3	j.ctrv.2022.102393	j.ctrv.2022.102393	PROPN
amwa-224	455	4	99	99	NUM
amwa-224	455	5	.	.	PUNCT
amwa-224	456	1	mullin	mullin	PROPN
amwa-224	456	2	r.	r.	PROPN
amwa-224	456	3	new	new	PROPN
amwa-224	456	4	day	day	NOUN
amwa-224	456	5	for	for	ADP
amwa-224	456	6	antibody	antibody	NOUN
amwa-224	456	7	-	-	PUNCT
amwa-224	456	8	drug	drug	NOUN
amwa-224	456	9	conjugates	conjugate	NOUN
amwa-224	456	10	.	.	PUNCT
amwa-224	457	1	chemical	chemical	PROPN
amwa-224	457	2	&	&	CCONJ
amwa-224	457	3	engineering	engineering	PROPN
amwa-224	457	4	news	news	NOUN
amwa-224	457	5	.	.	PUNCT
amwa-224	458	1	may	may	AUX
amwa-224	458	2	15	15	NUM
amwa-224	458	3	,	,	PUNCT
amwa-224	458	4	2022	2022	NUM
amwa-224	458	5	.	.	PUNCT
amwa-224	459	1	accessed	access	VERB
amwa-224	459	2	november	november	PROPN
amwa-224	459	3	23	23	NUM
amwa-224	459	4	,	,	PUNCT
amwa-224	459	5	2022	2022	NUM
amwa-224	459	6	.	.	PUNCT
amwa-224	460	1	https://cen.acs.org/pharmaceuticals/biologics/new-dayantibody-drug-conjugates/100/i17	https://cen.acs.org/pharmaceuticals/biologics/new-dayantibody-drug-conjugates/100/i17	ADP
amwa-224	460	2	general	general	ADJ
amwa-224	460	3	principles	principle	NOUN
amwa-224	460	4	of	of	ADP
amwa-224	460	5	word	word	NOUN
amwa-224	460	6	usage	usage	NOUN
amwa-224	460	7	www.amwa.org/online_learning	www.amwa.org/online_learne	VERB
amwa-224	460	8	choose	choose	VERB
amwa-224	460	9	the	the	DET
amwa-224	460	10	right	right	ADJ
amwa-224	460	11	word	word	NOUN
amwa-224	460	12	for	for	ADP
amwa-224	460	13	accuracy	accuracy	NOUN
amwa-224	460	14	and	and	CCONJ
amwa-224	460	15	clarity	clarity	NOUN
amwa-224	460	16	.	.	PUNCT
amwa-224	461	1	http://www.amwajournal.org	http://www.amwajournal.org	X
amwa-224	462	1	http://www.personalizedmedicinecoalition.org/userfiles/pmc-corporate/file/the_evolution_of_biomarker_use_in_clinical_trials_for_cancer_treatments.pdf	http://www.personalizedmedicinecoalition.org/userfiles/pmc-corporate/file/the_evolution_of_biomarker_use_in_clinical_trials_for_cancer_treatments.pdf	NOUN
amwa-224	462	2	http://www.personalizedmedicinecoalition.org/userfiles/pmc-corporate/file/the_evolution_of_biomarker_use_in_clinical_trials_for_cancer_treatments.pdf	http://www.personalizedmedicinecoalition.org/userfiles/pmc-corporate/file/the_evolution_of_biomarker_use_in_clinical_trials_for_cancer_treatments.pdf	NOUN
amwa-224	462	3	http://www.personalizedmedicinecoalition.org/userfiles/pmc-corporate/file/the_evolution_of_biomarker_use_in_clinical_trials_for_cancer_treatments.pdf	http://www.personalizedmedicinecoalition.org/userfiles/pmc-corporate/file/the_evolution_of_biomarker_use_in_clinical_trials_for_cancer_treatments.pdf	PROPN
amwa-224	462	4	https://www.biochempeg.com/article/74.html	https://www.biochempeg.com/article/74.html	PROPN
amwa-224	463	1	https://www.destinyclinicaltrials.com/en	https://www.destinyclinicaltrials.com/en	PROPN
amwa-224	463	2	https://www.fda.gov/drugs/resources-information-approved-drugs/fda-grants-regular-approval-fam-trastuzumab-deruxtecan-nxki-breast-cancer	https://www.fda.gov/drugs/resources-information-approved-drugs/fda-grants-regular-approval-fam-trastuzumab-deruxtecan-nxki-breast-cancer	NOUN
amwa-224	463	3	https://www.fda.gov/drugs/resources-information-approved-drugs/fda-grants-regular-approval-fam-trastuzumab-deruxtecan-nxki-breast-cancer	https://www.fda.gov/drugs/resources-information-approved-drugs/fda-grants-regular-approval-fam-trastuzumab-deruxtecan-nxki-breast-cancer	NOUN
amwa-224	463	4	https://www.fda.gov/drugs/resources-information-approved-drugs/fda-grants-regular-approval-fam-trastuzumab-deruxtecan-nxki-breast-cancer	https://www.fda.gov/drugs/resources-information-approved-drugs/fda-grants-regular-approval-fam-trastuzumab-deruxtecan-nxki-breast-cancer	NOUN
amwa-224	463	5	https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-fam-trastuzumab-deruxtecan-nxki-her2-positive-gastric-adenocarcinomas	https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-fam-trastuzumab-deruxtecan-nxki-her2-positive-gastric-adenocarcinomas	NOUN
amwa-224	463	6	https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-fam-trastuzumab-deruxtecan-nxki-her2-positive-gastric-adenocarcinomas	https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-fam-trastuzumab-deruxtecan-nxki-her2-positive-gastric-adenocarcinomas	NOUN
amwa-224	463	7	https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-fam-trastuzumab-deruxtecan-nxki-her2-positive-gastric-adenocarcinomas	https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-fam-trastuzumab-deruxtecan-nxki-her2-positive-gastric-adenocarcinomas	PROPN
amwa-224	463	8	https://www.fda.gov/drugs/resources-information-approved-drugs/fda-grants-accelerated-approval-fam-trastuzumab-deruxtecan-nxki-her2-mutant-non-small-cell-lung	https://www.fda.gov/drugs/resources-information-approved-drugs/fda-grants-accelerated-approval-fam-trastuzumab-deruxtecan-nxki-her2-mutant-non-small-cell-lung	PROPN
amwa-224	463	9	https://www.fda.gov/drugs/resources-information-approved-drugs/fda-grants-accelerated-approval-fam-trastuzumab-deruxtecan-nxki-her2-mutant-non-small-cell-lung	https://www.fda.gov/drugs/resources-information-approved-drugs/fda-grants-accelerated-approval-fam-trastuzumab-deruxtecan-nxki-her2-mutant-non-small-cell-lung	PROPN
amwa-224	463	10	https://www.fda.gov/drugs/resources-information-approved-drugs/fda-grants-accelerated-approval-fam-trastuzumab-deruxtecan-nxki-her2-mutant-non-small-cell-lung	https://www.fda.gov/drugs/resources-information-approved-drugs/fda-grants-accelerated-approval-fam-trastuzumab-deruxtecan-nxki-her2-mutant-non-small-cell-lung	PROPN
amwa-224	463	11	https://www.fda.gov/drugs/resources-information-approved-drugs/fda-grants-accelerated-approval-fam-trastuzumab-deruxtecan-nxki-her2-mutant-non-small-cell-lung	https://www.fda.gov/drugs/resources-information-approved-drugs/fda-grants-accelerated-approval-fam-trastuzumab-deruxtecan-nxki-her2-mutant-non-small-cell-lung	PROPN
amwa-224	463	12	https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-fam-trastuzumab-deruxtecan-nxki-her2-low-breast-cancer	https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-fam-trastuzumab-deruxtecan-nxki-her2-low-breast-cancer	NOUN
amwa-224	463	13	https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-fam-trastuzumab-deruxtecan-nxki-her2-low-breast-cancer	https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-fam-trastuzumab-deruxtecan-nxki-her2-low-breast-cancer	NOUN
amwa-224	463	14	https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-fam-trastuzumab-deruxtecan-nxki-her2-low-breast-cancer	https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-fam-trastuzumab-deruxtecan-nxki-her2-low-breast-cancer	X
amwa-224	463	15	https://cen.acs.org/pharmaceuticals/biologics/new-day-antibody-drug-conjugates/100/i17	https://cen.acs.org/pharmaceuticals/biologics/new-day-antibody-drug-conjugates/100/i17	X
amwa-224	463	16	https://cen.acs.org/pharmaceuticals/biologics/new-day-antibody-drug-conjugates/100/i17	https://cen.acs.org/pharmaceuticals/biologics/new-day-antibody-drug-conjugates/100/i17	X