id sid tid token lemma pos bracis-33624 1 1 comparative comparative ADJ bracis-33624 1 2 analysis analysis NOUN bracis-33624 1 3 of of ADP bracis-33624 1 4     SPACE bracis-33624 1 5 machine machine NOUN bracis-33624 1 6 learning learn VERB bracis-33624 1 7 algorithms algorithm NOUN bracis-33624 1 8 for for ADP bracis-33624 1 9     SPACE bracis-33624 1 10 identifying identify VERB bracis-33624 1 11 genetic genetic ADJ bracis-33624 1 12 markers marker NOUN bracis-33624 1 13 linked link VERB bracis-33624 1 14 to to ADP bracis-33624 1 15     SPACE bracis-33624 1 16 alzheimer alzheimer PROPN bracis-33624 1 17 ’s ’s PART bracis-33624 1 18 disease disease NOUN bracis-33624 1 19 | | ADV bracis-33624 1 20 springer springer NOUN bracis-33624 1 21 nature nature PROPN bracis-33624 1 22 link link PROPN bracis-33624 1 23 ( ( PUNCT bracis-33624 1 24 formerly formerly ADV bracis-33624 1 25 springerlink springerlink NOUN bracis-33624 1 26 ) ) PUNCT bracis-33624 1 27 skip skip VERB bracis-33624 1 28 to to ADP bracis-33624 1 29 main main ADJ bracis-33624 1 30 content content NOUN bracis-33624 1 31 advertisement advertisement NOUN bracis-33624 1 32 log log NOUN bracis-33624 1 33 in in ADP bracis-33624 1 34 menu menu NOUN bracis-33624 1 35 find find VERB bracis-33624 1 36 a a DET bracis-33624 1 37 journal journal NOUN bracis-33624 1 38 publish publish VERB bracis-33624 1 39 with with ADP bracis-33624 1 40 us we PRON bracis-33624 1 41 track track VERB bracis-33624 1 42 your your PRON bracis-33624 1 43 research research NOUN bracis-33624 1 44 search search NOUN bracis-33624 1 45 cart cart NOUN bracis-33624 1 46 home home NOUN bracis-33624 1 47 intelligent intelligent ADJ bracis-33624 1 48 systems system NOUN bracis-33624 1 49 conference conference NOUN bracis-33624 1 50 paper paper NOUN bracis-33624 1 51 comparative comparative ADJ bracis-33624 1 52 analysis analysis NOUN bracis-33624 1 53 of of ADP bracis-33624 1 54     SPACE bracis-33624 1 55 machine machine NOUN bracis-33624 1 56 learning learn VERB bracis-33624 1 57 algorithms algorithm NOUN bracis-33624 1 58 for for ADP bracis-33624 1 59     SPACE bracis-33624 1 60 identifying identify VERB bracis-33624 1 61 genetic genetic ADJ bracis-33624 1 62 markers marker NOUN bracis-33624 1 63 linked link VERB bracis-33624 1 64 to to ADP bracis-33624 1 65     SPACE bracis-33624 1 66 alzheimer alzheimer PROPN bracis-33624 1 67 ’s ’s PART bracis-33624 1 68 disease disease NOUN bracis-33624 1 69 conference conference NOUN bracis-33624 1 70 paper paper NOUN bracis-33624 1 71 first first ADV bracis-33624 1 72 online online ADV bracis-33624 1 73 : : PUNCT bracis-33624 1 74 30 30 NUM bracis-33624 1 75 january january NOUN bracis-33624 1 76 2025 2025 NUM bracis-33624 1 77 pp pp CCONJ bracis-33624 1 78 157–171 157–171 NUM bracis-33624 1 79 cite cite VERB bracis-33624 1 80 this this DET bracis-33624 1 81 conference conference NOUN bracis-33624 1 82 paper paper NOUN bracis-33624 1 83 access access NOUN bracis-33624 1 84 provided provide VERB bracis-33624 1 85 by by ADP bracis-33624 1 86 university university PROPN bracis-33624 1 87 of of ADP bracis-33624 1 88 notre notre PROPN bracis-33624 1 89 dame dame PROPN bracis-33624 1 90 hesburgh hesburgh PROPN bracis-33624 1 91 library library PROPN bracis-33624 1 92 download download PROPN bracis-33624 1 93 book book NOUN bracis-33624 1 94 pdf pdf PROPN bracis-33624 1 95 download download NOUN bracis-33624 1 96 book book NOUN bracis-33624 1 97 epub epub PROPN bracis-33624 1 98 intelligent intelligent ADJ bracis-33624 1 99 systems system NOUN bracis-33624 1 100 ( ( PUNCT bracis-33624 1 101 bracis bracis NOUN bracis-33624 1 102 2024 2024 NUM bracis-33624 1 103 ) ) PUNCT bracis-33624 1 104 comparative comparative ADJ bracis-33624 1 105 analysis analysis NOUN bracis-33624 1 106 of of ADP bracis-33624 1 107     SPACE bracis-33624 1 108 machine machine NOUN bracis-33624 1 109 learning learn VERB bracis-33624 1 110 algorithms algorithm NOUN bracis-33624 1 111 for for ADP bracis-33624 1 112     SPACE bracis-33624 1 113 identifying identify VERB bracis-33624 1 114 genetic genetic ADJ bracis-33624 1 115 markers marker NOUN bracis-33624 1 116 linked link VERB bracis-33624 1 117 to to ADP bracis-33624 1 118     SPACE bracis-33624 1 119 alzheimer alzheimer PROPN bracis-33624 1 120 ’s ’s PART bracis-33624 1 121 disease disease NOUN bracis-33624 1 122 download download NOUN bracis-33624 1 123 book book NOUN bracis-33624 1 124 pdf pdf PROPN bracis-33624 1 125 download download NOUN bracis-33624 1 126 book book PROPN bracis-33624 1 127 epub epub PROPN bracis-33624 1 128 juliana juliana PROPN bracis-33624 1 129 alves alve VERB bracis-33624 1 130     SPACE bracis-33624 1 131 orcid orcid NOUN bracis-33624 1 132 : : PUNCT bracis-33624 1 133 orcid.org/0000-0001-8143-80959 orcid.org/0000-0001-8143-80959 NOUN bracis-33624 1 134 , , PUNCT bracis-33624 1 135 eduardo eduardo PROPN bracis-33624 1 136 costa costa PROPN bracis-33624 1 137     SPACE bracis-33624 1 138 orcid orcid NOUN bracis-33624 1 139 : : PUNCT bracis-33624 1 140 orcid.org/0000-0003-1411-533810 orcid.org/0000-0003-1411-533810 NOUN bracis-33624 1 141 , , PUNCT bracis-33624 1 142 alencar alencar PROPN bracis-33624 1 143 xavier xavier PROPN bracis-33624 1 144     SPACE bracis-33624 1 145 orcid orcid PROPN bracis-33624 1 146 : : PUNCT bracis-33624 1 147 orcid.org/0000-0001-5034-995410,11 orcid.org/0000-0001-5034-995410,11 PROPN bracis-33624 1 148 , , PUNCT bracis-33624 1 149 luiz luiz PROPN bracis-33624 1 150 brito brito PROPN bracis-33624 1 151     SPACE bracis-33624 1 152 orcid orcid PROPN bracis-33624 1 153 : : PUNCT bracis-33624 1 154 orcid.org/0000-0002-5819-092211 orcid.org/0000-0002-5819-092211 PROPN bracis-33624 1 155 , , PUNCT bracis-33624 1 156 ricardo ricardo PROPN bracis-33624 1 157 cerri cerri PROPN bracis-33624 1 158     SPACE bracis-33624 1 159 orcid orcid PROPN bracis-33624 1 160 : : PUNCT bracis-33624 1 161 orcid.org/0000-0002-2582-169512 orcid.org/0000-0002-2582-169512 PROPN bracis-33624 1 162 & & CCONJ bracis-33624 1 163 alzheimer alzheimer PROPN bracis-33624 1 164 ’s ’s PART bracis-33624 1 165 disease disease NOUN bracis-33624 1 166 neuroimaging neuroimaging NOUN bracis-33624 1 167 initiative initiative NOUN bracis-33624 1 168 show show VERB bracis-33624 1 169 authors author NOUN bracis-33624 1 170 part part NOUN bracis-33624 1 171 of of ADP bracis-33624 1 172 the the DET bracis-33624 1 173 book book NOUN bracis-33624 1 174 series series NOUN bracis-33624 1 175 : : PUNCT bracis-33624 1 176 lecture lecture NOUN bracis-33624 1 177 notes note NOUN bracis-33624 1 178 in in ADP bracis-33624 1 179 computer computer NOUN bracis-33624 1 180 science science NOUN bracis-33624 1 181 ( ( PUNCT bracis-33624 1 182 ( ( PUNCT bracis-33624 1 183 lnai lnai ADJ bracis-33624 1 184 , , PUNCT bracis-33624 1 185 volume volume NOUN bracis-33624 1 186 15414 15414 NUM bracis-33624 1 187 ) ) PUNCT bracis-33624 1 188 ) ) PUNCT bracis-33624 1 189 included include VERB bracis-33624 1 190 in in ADP bracis-33624 1 191 the the DET bracis-33624 1 192 following follow VERB bracis-33624 1 193 conference conference NOUN bracis-33624 1 194 series series NOUN bracis-33624 1 195 : : PUNCT bracis-33624 1 196 brazilian brazilian ADJ bracis-33624 1 197 conference conference NOUN bracis-33624 1 198 on on ADP bracis-33624 1 199 intelligent intelligent ADJ bracis-33624 1 200 systems system NOUN bracis-33624 1 201 429 429 NUM bracis-33624 1 202 accesses access NOUN bracis-33624 1 203 abstract abstract VERB bracis-33624 1 204 the the DET bracis-33624 1 205 identification identification NOUN bracis-33624 1 206 of of ADP bracis-33624 1 207 genetic genetic ADJ bracis-33624 1 208 markers marker NOUN bracis-33624 1 209 for for ADP bracis-33624 1 210 complex complex ADJ bracis-33624 1 211 diseases disease NOUN bracis-33624 1 212 like like ADP bracis-33624 1 213 alzheimer alzheimer PROPN bracis-33624 1 214 ’s ’s PART bracis-33624 1 215 disease disease NOUN bracis-33624 1 216 ( ( PUNCT bracis-33624 1 217 ad ad NOUN bracis-33624 1 218 ) ) PUNCT bracis-33624 1 219 is be AUX bracis-33624 1 220 pivotal pivotal ADJ bracis-33624 1 221 in in ADP bracis-33624 1 222 medical medical ADJ bracis-33624 1 223 genomics genomic NOUN bracis-33624 1 224 . . PUNCT bracis-33624 2 1 this this DET bracis-33624 2 2 study study NOUN bracis-33624 2 3 aims aim VERB bracis-33624 2 4 to to PART bracis-33624 2 5 identify identify VERB bracis-33624 2 6 genetic genetic ADJ bracis-33624 2 7 markers marker NOUN bracis-33624 2 8 associated associate VERB bracis-33624 2 9 with with ADP bracis-33624 2 10 ad ad NOUN bracis-33624 2 11 by by ADP bracis-33624 2 12 introducing introduce VERB bracis-33624 2 13 a a DET bracis-33624 2 14 novel novel ADJ bracis-33624 2 15 approach approach NOUN bracis-33624 2 16 that that PRON bracis-33624 2 17 exclusively exclusively ADV bracis-33624 2 18 utilizes utilize VERB bracis-33624 2 19 genetic genetic ADJ bracis-33624 2 20 data datum NOUN bracis-33624 2 21 . . PUNCT bracis-33624 3 1 our our PRON bracis-33624 3 2 primary primary ADJ bracis-33624 3 3 goals goal NOUN bracis-33624 3 4 are be AUX bracis-33624 3 5 to to PART bracis-33624 3 6 benchmark benchmark VERB bracis-33624 3 7 explainable explainable ADJ bracis-33624 3 8 machine machine NOUN bracis-33624 3 9 learning learning NOUN bracis-33624 3 10 models model NOUN bracis-33624 3 11 against against ADP bracis-33624 3 12 blupf90 blupf90 NOUN bracis-33624 3 13 , , PUNCT bracis-33624 3 14 an an DET bracis-33624 3 15 advanced advanced ADJ bracis-33624 3 16 mixed mixed ADJ bracis-33624 3 17 linear linear ADJ bracis-33624 3 18 model model NOUN bracis-33624 3 19 approach approach NOUN bracis-33624 3 20 , , PUNCT bracis-33624 3 21 and and CCONJ bracis-33624 3 22 to to PART bracis-33624 3 23 uncover uncover VERB bracis-33624 3 24 single single ADJ bracis-33624 3 25 nucleotide nucleotide ADJ bracis-33624 3 26 polymorphisms polymorphism NOUN bracis-33624 3 27 ( ( PUNCT bracis-33624 3 28 snps snps PROPN bracis-33624 3 29 ) ) PUNCT bracis-33624 3 30 crucial crucial ADJ bracis-33624 3 31 for for ADP bracis-33624 3 32 ad ad NOUN bracis-33624 3 33 . . PUNCT bracis-33624 4 1 we we PRON bracis-33624 4 2 analyze analyze VERB bracis-33624 4 3 snps snps PROPN bracis-33624 4 4 to to PART bracis-33624 4 5 achieve achieve VERB bracis-33624 4 6 these these DET bracis-33624 4 7 goals goal NOUN bracis-33624 4 8 , , PUNCT bracis-33624 4 9 focusing focus VERB bracis-33624 4 10 on on ADP bracis-33624 4 11 the the DET bracis-33624 4 12 genetic genetic ADJ bracis-33624 4 13 heritability heritability NOUN bracis-33624 4 14 rate rate NOUN bracis-33624 4 15 of of ADP bracis-33624 4 16 58–79 58–79 NUM bracis-33624 4 17 % % NOUN bracis-33624 4 18 for for ADP bracis-33624 4 19 ad ad NOUN bracis-33624 4 20     SPACE bracis-33624 5 1 [ [ X bracis-33624 5 2 12 12 NUM bracis-33624 5 3 ] ] PUNCT bracis-33624 5 4 . . PUNCT bracis-33624 6 1 our our PRON bracis-33624 6 2 methodology methodology NOUN bracis-33624 6 3 focuses focus VERB bracis-33624 6 4 solely solely ADV bracis-33624 6 5 on on ADP bracis-33624 6 6 genetic genetic ADJ bracis-33624 6 7 data datum NOUN bracis-33624 6 8 to to PART bracis-33624 6 9 uncover uncover VERB bracis-33624 6 10 snps snps PROPN bracis-33624 6 11 crucial crucial ADJ bracis-33624 6 12 for for ADP bracis-33624 6 13 ad ad NOUN bracis-33624 6 14 , , PUNCT bracis-33624 6 15 employing employ VERB bracis-33624 6 16 transparent transparent ADJ bracis-33624 6 17 computational computational ADJ bracis-33624 6 18 models model NOUN bracis-33624 6 19 to to PART bracis-33624 6 20 ensure ensure VERB bracis-33624 6 21 interpretability interpretability NOUN bracis-33624 6 22 alongside alongside ADP bracis-33624 6 23 predictive predictive ADJ bracis-33624 6 24 power power NOUN bracis-33624 6 25 . . PUNCT bracis-33624 7 1 the the DET bracis-33624 7 2 findings finding NOUN bracis-33624 7 3 demonstrate demonstrate VERB bracis-33624 7 4 the the DET bracis-33624 7 5 efficacy efficacy NOUN bracis-33624 7 6 of of ADP bracis-33624 7 7 a a DET bracis-33624 7 8 purely purely ADV bracis-33624 7 9 genomic genomic ADJ bracis-33624 7 10 approach approach NOUN bracis-33624 7 11 combined combine VERB bracis-33624 7 12 with with ADP bracis-33624 7 13 machine machine NOUN bracis-33624 7 14 learning learn VERB bracis-33624 7 15 to to PART bracis-33624 7 16 advance advance VERB bracis-33624 7 17 our our PRON bracis-33624 7 18 understanding understanding NOUN bracis-33624 7 19 of of ADP bracis-33624 7 20 ad ad NOUN bracis-33624 7 21 . . PUNCT bracis-33624 8 1 our our PRON bracis-33624 8 2 methodology methodology NOUN bracis-33624 8 3 successfully successfully ADV bracis-33624 8 4 identified identify VERB bracis-33624 8 5 a a DET bracis-33624 8 6 robust robust ADJ bracis-33624 8 7 set set NOUN bracis-33624 8 8 of of ADP bracis-33624 8 9 snps snps PROPN bracis-33624 8 10 associated associate VERB bracis-33624 8 11 with with ADP bracis-33624 8 12 ad ad NOUN bracis-33624 8 13 , , PUNCT bracis-33624 8 14 encompassing encompass VERB bracis-33624 8 15 both both PRON bracis-33624 8 16 previously previously ADV bracis-33624 8 17 recognized recognize VERB bracis-33624 8 18 and and CCONJ bracis-33624 8 19 novel novel ADJ bracis-33624 8 20 snps snps NOUN bracis-33624 8 21 . . PUNCT bracis-33624 9 1 the the DET bracis-33624 9 2 machine machine NOUN bracis-33624 9 3 learning learning NOUN bracis-33624 9 4 models model NOUN bracis-33624 9 5 employed employ VERB bracis-33624 9 6 delineated delineate VERB bracis-33624 9 7 distinct distinct ADJ bracis-33624 9 8 snp snp ADJ bracis-33624 9 9 profiles profile NOUN bracis-33624 9 10 , , PUNCT bracis-33624 9 11 highlighting highlight VERB bracis-33624 9 12 the the DET bracis-33624 9 13 complexity complexity NOUN bracis-33624 9 14 and and CCONJ bracis-33624 9 15 heterogeneity heterogeneity NOUN bracis-33624 9 16 of of ADP bracis-33624 9 17 ad ad NOUN bracis-33624 9 18 . . PUNCT bracis-33624 10 1 these these DET bracis-33624 10 2 results result NOUN bracis-33624 10 3 not not PART bracis-33624 10 4 only only ADV bracis-33624 10 5 deepen deepen VERB bracis-33624 10 6 our our PRON bracis-33624 10 7 understanding understanding NOUN bracis-33624 10 8 of of ADP bracis-33624 10 9 ad ad NOUN bracis-33624 10 10 ’s ’s PART bracis-33624 10 11 genetic genetic ADJ bracis-33624 10 12 underpinnings underpinning NOUN bracis-33624 10 13 but but CCONJ bracis-33624 10 14 also also ADV bracis-33624 10 15 facilitate facilitate VERB bracis-33624 10 16 the the DET bracis-33624 10 17 development development NOUN bracis-33624 10 18 of of ADP bracis-33624 10 19 targeted target VERB bracis-33624 10 20 therapeutic therapeutic ADJ bracis-33624 10 21 and and CCONJ bracis-33624 10 22 diagnostic diagnostic ADJ bracis-33624 10 23 strategies strategy NOUN bracis-33624 10 24 , , PUNCT bracis-33624 10 25 showcasing showcase VERB bracis-33624 10 26 the the DET bracis-33624 10 27 potential potential NOUN bracis-33624 10 28 of of ADP bracis-33624 10 29 computational computational ADJ bracis-33624 10 30 techniques technique NOUN bracis-33624 10 31 in in ADP bracis-33624 10 32 medical medical ADJ bracis-33624 10 33 genomics genomic NOUN bracis-33624 10 34 . . PUNCT bracis-33624 11 1 data datum NOUN bracis-33624 11 2 used use VERB bracis-33624 11 3 in in ADP bracis-33624 11 4 preparation preparation NOUN bracis-33624 11 5 of of ADP bracis-33624 11 6 this this DET bracis-33624 11 7 article article NOUN bracis-33624 11 8 were be AUX bracis-33624 11 9 obtained obtain VERB bracis-33624 11 10 from from ADP bracis-33624 11 11 the the DET bracis-33624 11 12 alzheimer alzheimer PROPN bracis-33624 11 13 ’s ’s PART bracis-33624 11 14 disease disease NOUN bracis-33624 11 15 neuroimaging neuroimaging NOUN bracis-33624 11 16 initiative initiative NOUN bracis-33624 11 17 ( ( PUNCT bracis-33624 11 18 adni adni ADJ bracis-33624 11 19 ) ) PUNCT bracis-33624 11 20 database database NOUN bracis-33624 11 21 ( ( PUNCT bracis-33624 11 22 adni.loni.usc.edu adni.loni.usc.edu NOUN bracis-33624 11 23 ) ) PUNCT bracis-33624 11 24 . . PUNCT bracis-33624 12 1 as as ADP bracis-33624 12 2 such such ADJ bracis-33624 12 3 , , PUNCT bracis-33624 12 4 the the DET bracis-33624 12 5 investigators investigator NOUN bracis-33624 12 6 within within ADP bracis-33624 12 7 the the DET bracis-33624 12 8 adni adni PROPN bracis-33624 12 9 contributed contribute VERB bracis-33624 12 10 to to ADP bracis-33624 12 11 the the DET bracis-33624 12 12 design design NOUN bracis-33624 12 13 and and CCONJ bracis-33624 12 14 implementation implementation NOUN bracis-33624 12 15 of of ADP bracis-33624 12 16 adni adni PRON bracis-33624 12 17 and/or and/or CCONJ bracis-33624 12 18 provided provide VERB bracis-33624 12 19 data datum NOUN bracis-33624 12 20 but but CCONJ bracis-33624 12 21 did do AUX bracis-33624 12 22 not not PART bracis-33624 12 23 participate participate VERB bracis-33624 12 24 in in ADP bracis-33624 12 25 analysis analysis NOUN bracis-33624 12 26 or or CCONJ bracis-33624 12 27 writing writing NOUN bracis-33624 12 28 of of ADP bracis-33624 12 29 this this DET bracis-33624 12 30 report report NOUN bracis-33624 12 31 . . PUNCT bracis-33624 13 1 a a DET bracis-33624 13 2 complete complete ADJ bracis-33624 13 3 listing listing NOUN bracis-33624 13 4 of of ADP bracis-33624 13 5 adni adni DET bracis-33624 13 6 investigators investigator NOUN bracis-33624 13 7 can can AUX bracis-33624 13 8 be be AUX bracis-33624 13 9 found find VERB bracis-33624 13 10 at at ADP bracis-33624 13 11 : : PUNCT bracis-33624 13 12 http://adni.loni.usc.edu/wp-content/uploads/how_to_apply/adni_acknowledgement_list.pdf http://adni.loni.usc.edu/wp-content/uploads/how_to_apply/adni_acknowledgement_list.pdf NOUN bracis-33624 13 13 . . PUNCT bracis-33624 14 1 access access NOUN bracis-33624 14 2 provided provide VERB bracis-33624 14 3 by by ADP bracis-33624 14 4 university university PROPN bracis-33624 14 5 of of ADP bracis-33624 14 6 notre notre PROPN bracis-33624 14 7 dame dame PROPN bracis-33624 14 8 hesburgh hesburgh PROPN bracis-33624 14 9 library library PROPN bracis-33624 14 10 . . PUNCT bracis-33624 15 1 download download PROPN bracis-33624 15 2 conference conference NOUN bracis-33624 15 3 paper paper NOUN bracis-33624 15 4 pdf pdf NOUN bracis-33624 15 5 similar similar ADJ bracis-33624 15 6 content content NOUN bracis-33624 15 7 being be AUX bracis-33624 15 8 viewed view VERB bracis-33624 15 9 by by ADP bracis-33624 15 10 others other NOUN bracis-33624 15 11 machine machine NOUN bracis-33624 15 12 learning learn VERB bracis-33624 15 13 in in ADP bracis-33624 15 14 alzheimer alzheimer PROPN bracis-33624 15 15 ’s ’s PART bracis-33624 15 16 disease disease NOUN bracis-33624 15 17 genetics genetic NOUN bracis-33624 15 18 article article NOUN bracis-33624 15 19 open open VERB bracis-33624 15 20 access access NOUN bracis-33624 15 21 22 22 NUM bracis-33624 15 22 july july NOUN bracis-33624 15 23 2025 2025 NUM bracis-33624 15 24 predicting predict VERB bracis-33624 15 25 early early PROPN bracis-33624 15 26 alzheimer alzheimer PROPN bracis-33624 15 27 ’s ’s PART bracis-33624 15 28 with with ADP bracis-33624 15 29 blood blood NOUN bracis-33624 15 30 biomarkers biomarker NOUN bracis-33624 15 31 and and CCONJ bracis-33624 15 32 clinical clinical ADJ bracis-33624 15 33 features feature NOUN bracis-33624 15 34 article article NOUN bracis-33624 15 35 open open ADJ bracis-33624 15 36 access access NOUN bracis-33624 15 37 13 13 NUM bracis-33624 15 38 march march NOUN bracis-33624 15 39 2024 2024 NUM bracis-33624 15 40 identifying identify VERB bracis-33624 15 41 key key ADJ bracis-33624 15 42 genetic genetic ADJ bracis-33624 15 43 variants variant NOUN bracis-33624 15 44 in in ADP bracis-33624 15 45 alzheimer alzheimer PROPN bracis-33624 15 46 ’s ’s PART bracis-33624 15 47 disease disease NOUN bracis-33624 15 48 progression progression NOUN bracis-33624 15 49 using use VERB bracis-33624 15 50 graph graph NOUN bracis-33624 15 51 convolutional convolutional ADJ bracis-33624 15 52 networks network NOUN bracis-33624 15 53 ( ( PUNCT bracis-33624 15 54 gcn gcn NOUN bracis-33624 15 55 ) ) PUNCT bracis-33624 15 56 and and CCONJ bracis-33624 15 57 biological biological ADJ bracis-33624 15 58 impact impact NOUN bracis-33624 15 59 analysis analysis NOUN bracis-33624 15 60 article article NOUN bracis-33624 15 61 open open VERB bracis-33624 15 62 access access NOUN bracis-33624 15 63 16 16 NUM bracis-33624 15 64 july july NOUN bracis-33624 15 65 2025 2025 NUM bracis-33624 15 66 1 1 NUM bracis-33624 15 67 introduction introduction NOUN bracis-33624 15 68 alzheimer alzheimer PROPN bracis-33624 15 69 ’s ’s PART bracis-33624 15 70 disease disease NOUN bracis-33624 15 71 ( ( PUNCT bracis-33624 15 72 ad ad NOUN bracis-33624 15 73 ) ) PUNCT bracis-33624 15 74 is be AUX bracis-33624 15 75 a a DET bracis-33624 15 76 progressive progressive ADJ bracis-33624 15 77 neurodegenerative neurodegenerative ADJ bracis-33624 15 78 disorder disorder NOUN bracis-33624 15 79 associated associate VERB bracis-33624 15 80 with with ADP bracis-33624 15 81 aging aging NOUN bracis-33624 15 82 . . PUNCT bracis-33624 16 1 it it PRON bracis-33624 16 2 can can AUX bracis-33624 16 3 cause cause VERB bracis-33624 16 4 cognitive cognitive ADJ bracis-33624 16 5 and and CCONJ bracis-33624 16 6 psychiatric psychiatric ADJ bracis-33624 16 7 symptoms symptom NOUN bracis-33624 16 8 , , PUNCT bracis-33624 16 9 potentially potentially ADV bracis-33624 16 10 leading lead VERB bracis-33624 16 11 to to ADP bracis-33624 16 12 disability disability NOUN bracis-33624 16 13 . . PUNCT bracis-33624 17 1 according accord VERB bracis-33624 17 2 to to ADP bracis-33624 17 3 the the DET bracis-33624 17 4 world world PROPN bracis-33624 17 5 alzheimer alzheimer PROPN bracis-33624 17 6 report report PROPN bracis-33624 17 7 , , PUNCT bracis-33624 17 8 the the DET bracis-33624 17 9 number number NOUN bracis-33624 17 10 of of ADP bracis-33624 17 11 ad ad NOUN bracis-33624 17 12 cases case NOUN bracis-33624 17 13 is be AUX bracis-33624 17 14 projected project VERB bracis-33624 17 15 to to PART bracis-33624 17 16 reach reach VERB bracis-33624 17 17 131.5 131.5 NUM bracis-33624 17 18 million million NUM bracis-33624 17 19 by by ADP bracis-33624 17 20 2050 2050 NUM bracis-33624 17 21     SPACE bracis-33624 18 1 [ [ X bracis-33624 18 2 29 29 NUM bracis-33624 18 3 ] ] PUNCT bracis-33624 18 4 . . PUNCT bracis-33624 19 1 ad ad NOUN bracis-33624 19 2 is be AUX bracis-33624 19 3 characterized characterize VERB bracis-33624 19 4 by by ADP bracis-33624 19 5 synaptic synaptic ADJ bracis-33624 19 6 damage damage NOUN bracis-33624 19 7 and and CCONJ bracis-33624 19 8 neuronal neuronal ADJ bracis-33624 19 9 loss loss NOUN bracis-33624 19 10 in in ADP bracis-33624 19 11 brain brain NOUN bracis-33624 19 12 regions region NOUN bracis-33624 19 13 responsible responsible ADJ bracis-33624 19 14 for for ADP bracis-33624 19 15 cognitive cognitive ADJ bracis-33624 19 16 function function NOUN bracis-33624 19 17     SPACE bracis-33624 20 1 [ [ X bracis-33624 20 2 33 33 NUM bracis-33624 20 3 ] ] PUNCT bracis-33624 20 4 . . PUNCT bracis-33624 21 1 researchers researcher NOUN bracis-33624 21 2 have have AUX bracis-33624 21 3 been be AUX bracis-33624 21 4 looking look VERB bracis-33624 21 5 for for ADP bracis-33624 21 6 genetic genetic ADJ bracis-33624 21 7 markers marker NOUN bracis-33624 21 8 linked link VERB bracis-33624 21 9 to to ADP bracis-33624 21 10 alzheimer alzheimer PROPN bracis-33624 21 11 ’s ’s PART bracis-33624 21 12 disease disease NOUN bracis-33624 21 13 ( ( PUNCT bracis-33624 21 14 ad ad NOUN bracis-33624 21 15 ) ) PUNCT bracis-33624 21 16 to to PART bracis-33624 21 17 create create VERB bracis-33624 21 18 personalized personalized ADJ bracis-33624 21 19 medicine medicine NOUN bracis-33624 21 20 for for ADP bracis-33624 21 21 individuals individual NOUN bracis-33624 21 22 at at ADP bracis-33624 21 23 risk risk NOUN bracis-33624 21 24 and and CCONJ bracis-33624 21 25 enhance enhance VERB bracis-33624 21 26 their their PRON bracis-33624 21 27 quality quality NOUN bracis-33624 21 28 of of ADP bracis-33624 21 29 life life NOUN bracis-33624 21 30 . . PUNCT bracis-33624 22 1 the the DET bracis-33624 22 2 human human ADJ bracis-33624 22 3 genome genome NOUN bracis-33624 22 4 project project NOUN bracis-33624 22 5 , , PUNCT bracis-33624 22 6 initiated initiate VERB bracis-33624 22 7 in in ADP bracis-33624 22 8 the the DET bracis-33624 22 9 mid-1990s mid-1990 NOUN bracis-33624 22 10 , , PUNCT bracis-33624 22 11 greatly greatly ADV bracis-33624 22 12 expanded expand VERB bracis-33624 22 13 genetic genetic ADJ bracis-33624 22 14 data datum NOUN bracis-33624 22 15 availability availability NOUN bracis-33624 22 16 through through ADP bracis-33624 22 17 dna dna PROPN bracis-33624 22 18 sequencing sequencing NOUN bracis-33624 22 19 . . PUNCT bracis-33624 23 1 today today NOUN bracis-33624 23 2 , , PUNCT bracis-33624 23 3 personalized personalized ADJ bracis-33624 23 4 medicine medicine NOUN bracis-33624 23 5 incorporates incorporate VERB bracis-33624 23 6 tailored tailor VERB bracis-33624 23 7 medical medical ADJ bracis-33624 23 8 treatments treatment NOUN bracis-33624 23 9 based base VERB bracis-33624 23 10 on on ADP bracis-33624 23 11 an an DET bracis-33624 23 12 individual individual NOUN bracis-33624 23 13 ’s ’s PART bracis-33624 23 14 genetic genetic ADJ bracis-33624 23 15 characteristics characteristic NOUN bracis-33624 23 16 , , PUNCT bracis-33624 23 17 including include VERB bracis-33624 23 18 factors factor NOUN bracis-33624 23 19 like like ADP bracis-33624 23 20 single single ADJ bracis-33624 23 21 nucleotide nucleotide ADJ bracis-33624 23 22 polymorphisms polymorphism NOUN bracis-33624 23 23 ( ( PUNCT bracis-33624 23 24 snps snps PROPN bracis-33624 23 25 ) ) PUNCT bracis-33624 23 26 that that PRON bracis-33624 23 27 aid aid NOUN bracis-33624 23 28 in in ADP bracis-33624 23 29 predicting predict VERB bracis-33624 23 30 disease disease NOUN bracis-33624 23 31 risk risk NOUN bracis-33624 23 32 for for ADP bracis-33624 23 33 individuals individual NOUN bracis-33624 23 34     SPACE bracis-33624 24 1 [ [ X bracis-33624 24 2 22 22 NUM bracis-33624 24 3 ] ] PUNCT bracis-33624 24 4 . . PUNCT bracis-33624 25 1 this this DET bracis-33624 25 2 study study NOUN bracis-33624 25 3 seeks seek VERB bracis-33624 25 4 to to PART bracis-33624 25 5 find find VERB bracis-33624 25 6 genetic genetic ADJ bracis-33624 25 7 markers marker NOUN bracis-33624 25 8 , , PUNCT bracis-33624 25 9 like like ADP bracis-33624 25 10 single single ADJ bracis-33624 25 11 nucleotide nucleotide ADJ bracis-33624 25 12 polymorphisms polymorphism NOUN bracis-33624 25 13 ( ( PUNCT bracis-33624 25 14 snps snps PROPN bracis-33624 25 15 ) ) PUNCT bracis-33624 25 16 , , PUNCT bracis-33624 25 17 that that PRON bracis-33624 25 18 are be AUX bracis-33624 25 19 linked link VERB bracis-33624 25 20 to to ADP bracis-33624 25 21 ad ad NOUN bracis-33624 25 22 . . PUNCT bracis-33624 26 1 this this DET bracis-33624 26 2 type type NOUN bracis-33624 26 3 of of ADP bracis-33624 26 4 research research NOUN bracis-33624 26 5 is be AUX bracis-33624 26 6 called call VERB bracis-33624 26 7 genome genome NOUN bracis-33624 26 8 - - PUNCT bracis-33624 26 9 wide wide ADJ bracis-33624 26 10 association association NOUN bracis-33624 26 11 studies study NOUN bracis-33624 26 12 ( ( PUNCT bracis-33624 26 13 gwas gwas PROPN bracis-33624 26 14 ) ) PUNCT bracis-33624 26 15 . . PUNCT bracis-33624 27 1 snps snps PROPN bracis-33624 27 2 are be AUX bracis-33624 27 3 variations variation NOUN bracis-33624 27 4 at at ADP bracis-33624 27 5 specific specific ADJ bracis-33624 27 6 locations location NOUN bracis-33624 27 7 in in ADP bracis-33624 27 8 the the DET bracis-33624 27 9 dna dna PROPN bracis-33624 27 10 chain chain NOUN bracis-33624 27 11 and and CCONJ bracis-33624 27 12 are be AUX bracis-33624 27 13 classified classify VERB bracis-33624 27 14 based base VERB bracis-33624 27 15 on on ADP bracis-33624 27 16 the the DET bracis-33624 27 17 type type NOUN bracis-33624 27 18 of of ADP bracis-33624 27 19 nucleotide nucleotide ADJ bracis-33624 27 20 substitution substitution NOUN bracis-33624 27 21 that that PRON bracis-33624 27 22 takes take VERB bracis-33624 27 23 place place NOUN bracis-33624 27 24     SPACE bracis-33624 28 1 [ [ X bracis-33624 28 2 10 10 NUM bracis-33624 28 3 ] ] PUNCT bracis-33624 28 4 . . PUNCT bracis-33624 29 1 snps snps PROPN bracis-33624 29 2 are be AUX bracis-33624 29 3 the the DET bracis-33624 29 4 most most ADV bracis-33624 29 5 commonly commonly ADV bracis-33624 29 6 occurring occur VERB bracis-33624 29 7 type type NOUN bracis-33624 29 8 of of ADP bracis-33624 29 9 genetic genetic ADJ bracis-33624 29 10 polymorphism polymorphism NOUN bracis-33624 29 11 in in ADP bracis-33624 29 12 human human ADJ bracis-33624 29 13 genetics genetic NOUN bracis-33624 29 14 , , PUNCT bracis-33624 29 15 and and CCONJ bracis-33624 29 16 can can AUX bracis-33624 29 17 impact impact VERB bracis-33624 29 18 various various ADJ bracis-33624 29 19 human human ADJ bracis-33624 29 20 traits trait NOUN bracis-33624 29 21 and and CCONJ bracis-33624 29 22 their their PRON bracis-33624 29 23 development development NOUN bracis-33624 29 24 in in ADP bracis-33624 29 25 a a DET bracis-33624 29 26 specific specific ADJ bracis-33624 29 27 environment environment NOUN bracis-33624 29 28 . . PUNCT bracis-33624 30 1 additionally additionally ADV bracis-33624 30 2 , , PUNCT bracis-33624 30 3 snps snps PROPN bracis-33624 30 4 are be AUX bracis-33624 30 5 evolutionarily evolutionarily ADV bracis-33624 30 6 stable stable ADJ bracis-33624 30 7 , , PUNCT bracis-33624 30 8 meaning mean VERB bracis-33624 30 9 that that SCONJ bracis-33624 30 10 there there PRON bracis-33624 30 11 is be VERB bracis-33624 30 12 little little ADJ bracis-33624 30 13 variation variation NOUN bracis-33624 30 14 among among ADP bracis-33624 30 15 different different ADJ bracis-33624 30 16 generations generation NOUN bracis-33624 30 17     SPACE bracis-33624 31 1 [ [ X bracis-33624 31 2 10 10 NUM bracis-33624 31 3 ] ] PUNCT bracis-33624 31 4 . . PUNCT bracis-33624 32 1 in in ADP bracis-33624 32 2 gwas gwas PROPN bracis-33624 32 3 , , PUNCT bracis-33624 32 4 genotypic genotypic NOUN bracis-33624 32 5 and and CCONJ bracis-33624 32 6 phenotypic phenotypic ADJ bracis-33624 32 7 data datum NOUN bracis-33624 32 8 are be AUX bracis-33624 32 9 collected collect VERB bracis-33624 32 10 from from ADP bracis-33624 32 11 diverse diverse ADJ bracis-33624 32 12 individuals individual NOUN bracis-33624 32 13 , , PUNCT bracis-33624 32 14 and and CCONJ bracis-33624 32 15 quality quality NOUN bracis-33624 32 16 control control NOUN bracis-33624 32 17 procedures procedure NOUN bracis-33624 32 18 ensure ensure VERB bracis-33624 32 19 the the DET bracis-33624 32 20 data datum NOUN bracis-33624 32 21 ’s ’s PART bracis-33624 32 22 reliability reliability NOUN bracis-33624 32 23 . . PUNCT bracis-33624 33 1 after after ADP bracis-33624 33 2 gwas gwas PROPN bracis-33624 33 3 , , PUNCT bracis-33624 33 4 analyses analysis NOUN bracis-33624 33 5 are be AUX bracis-33624 33 6 performed perform VERB bracis-33624 33 7 to to PART bracis-33624 33 8 interpret interpret VERB bracis-33624 33 9 the the DET bracis-33624 33 10 results result NOUN bracis-33624 33 11 . . PUNCT bracis-33624 34 1 these these DET bracis-33624 34 2 analyses analysis NOUN bracis-33624 34 3 involve involve VERB bracis-33624 34 4 adjusting adjust VERB bracis-33624 34 5 the the DET bracis-33624 34 6 significance significance NOUN bracis-33624 34 7 threshold threshold NOUN bracis-33624 34 8 , , PUNCT bracis-33624 34 9 presenting present VERB bracis-33624 34 10 results result NOUN bracis-33624 34 11 in in ADP bracis-33624 34 12 a a DET bracis-33624 34 13 manhattan manhattan PROPN bracis-33624 34 14 plot plot NOUN bracis-33624 34 15 , , PUNCT bracis-33624 34 16 and and CCONJ bracis-33624 34 17 conducting conduct VERB bracis-33624 34 18 bioinformatics bioinformatics NOUN bracis-33624 34 19 analyses analysis NOUN bracis-33624 34 20 to to PART bracis-33624 34 21 identify identify VERB bracis-33624 34 22 biological biological ADJ bracis-33624 34 23 mechanisms mechanism NOUN bracis-33624 34 24 underlying underlie VERB bracis-33624 34 25 observed observed ADJ bracis-33624 34 26 associations association NOUN bracis-33624 34 27 . . PUNCT bracis-33624 35 1 gwas gwas PROPN bracis-33624 35 2 is be AUX bracis-33624 35 3 a a DET bracis-33624 35 4 powerful powerful ADJ bracis-33624 35 5 approach approach NOUN bracis-33624 35 6 for for ADP bracis-33624 35 7 identifying identify VERB bracis-33624 35 8 genetic genetic ADJ bracis-33624 35 9 variants variant NOUN bracis-33624 35 10 associated associate VERB bracis-33624 35 11 with with ADP bracis-33624 35 12 complex complex ADJ bracis-33624 35 13 diseases disease NOUN bracis-33624 35 14 or or CCONJ bracis-33624 35 15 traits trait NOUN bracis-33624 35 16 , , PUNCT bracis-33624 35 17 but but CCONJ bracis-33624 35 18 it it PRON bracis-33624 35 19 is be AUX bracis-33624 35 20 essential essential ADJ bracis-33624 35 21 to to PART bracis-33624 35 22 consider consider VERB bracis-33624 35 23 various various ADJ bracis-33624 35 24 factors factor NOUN bracis-33624 35 25 carefully carefully ADV bracis-33624 35 26 to to PART bracis-33624 35 27 ensure ensure VERB bracis-33624 35 28 valid valid ADJ bracis-33624 35 29 and and CCONJ bracis-33624 35 30 interpretable interpretable ADJ bracis-33624 35 31 results result NOUN bracis-33624 35 32 . . PUNCT bracis-33624 36 1 advancements advancement NOUN bracis-33624 36 2 in in ADP bracis-33624 36 3 dna dna NOUN bracis-33624 36 4 sequencing sequencing NOUN bracis-33624 36 5 technologies technology NOUN bracis-33624 36 6 have have AUX bracis-33624 36 7 resulted result VERB bracis-33624 36 8 in in ADP bracis-33624 36 9 an an DET bracis-33624 36 10 abundance abundance NOUN bracis-33624 36 11 of of ADP bracis-33624 36 12 genetic genetic ADJ bracis-33624 36 13 data datum NOUN bracis-33624 36 14 , , PUNCT bracis-33624 36 15 leading lead VERB bracis-33624 36 16 to to ADP bracis-33624 36 17 improvement improvement NOUN bracis-33624 36 18 of of ADP bracis-33624 36 19 personalized personalized ADJ bracis-33624 36 20 medicine medicine NOUN bracis-33624 36 21 [ [ X bracis-33624 36 22 5 5 NUM bracis-33624 36 23 , , PUNCT bracis-33624 36 24 20 20 NUM bracis-33624 36 25 , , PUNCT bracis-33624 36 26 22 22 NUM bracis-33624 36 27 , , PUNCT bracis-33624 36 28 35 35 NUM bracis-33624 36 29 ] ] PUNCT bracis-33624 36 30 . . PUNCT bracis-33624 37 1 the the DET bracis-33624 37 2 rapid rapid ADJ bracis-33624 37 3 growth growth NOUN bracis-33624 37 4 of of ADP bracis-33624 37 5 data datum NOUN bracis-33624 37 6 has have AUX bracis-33624 37 7 made make VERB bracis-33624 37 8 machine machine NOUN bracis-33624 37 9 learning learning NOUN bracis-33624 37 10 algorithms algorithm NOUN bracis-33624 37 11 a a DET bracis-33624 37 12 valuable valuable ADJ bracis-33624 37 13 tool tool NOUN bracis-33624 37 14 in in ADP bracis-33624 37 15 genetics genetic NOUN bracis-33624 37 16 . . PUNCT bracis-33624 38 1 researchers researcher NOUN bracis-33624 38 2 have have AUX bracis-33624 38 3 shown show VERB bracis-33624 38 4 that that SCONJ bracis-33624 38 5 machine machine NOUN bracis-33624 38 6 learning learn VERB bracis-33624 38 7 techniques technique NOUN bracis-33624 38 8 can can AUX bracis-33624 38 9 predict predict VERB bracis-33624 38 10 diseases disease NOUN bracis-33624 38 11 based base VERB bracis-33624 38 12 on on ADP bracis-33624 38 13 genetic genetic ADJ bracis-33624 38 14 factors factor NOUN bracis-33624 38 15 . . PUNCT bracis-33624 39 1 in in ADP bracis-33624 39 2 the the DET bracis-33624 39 3 domain domain NOUN bracis-33624 39 4 of of ADP bracis-33624 39 5 machine machine NOUN bracis-33624 39 6 learning learning NOUN bracis-33624 39 7 , , PUNCT bracis-33624 39 8 algorithms algorithm NOUN bracis-33624 39 9 are be AUX bracis-33624 39 10 designed design VERB bracis-33624 39 11 to to PART bracis-33624 39 12 model model VERB bracis-33624 39 13 the the DET bracis-33624 39 14 intricate intricate ADJ bracis-33624 39 15 associations association NOUN bracis-33624 39 16 between between ADP bracis-33624 39 17 risk risk NOUN bracis-33624 39 18 single single ADJ bracis-33624 39 19 nucleotide nucleotide NOUN bracis-33624 39 20 polymorphisms polymorphism NOUN bracis-33624 39 21 ( ( PUNCT bracis-33624 39 22 snps snps PROPN bracis-33624 39 23 ) ) PUNCT bracis-33624 39 24 and and CCONJ bracis-33624 39 25 disease disease NOUN bracis-33624 39 26 phenotypes phenotype NOUN bracis-33624 39 27 [ [ X bracis-33624 39 28 17 17 NUM bracis-33624 39 29 ] ] PUNCT bracis-33624 39 30 . . PUNCT bracis-33624 40 1 supervised supervised ADJ bracis-33624 40 2 learning learning NOUN bracis-33624 40 3 techniques technique NOUN bracis-33624 40 4 are be AUX bracis-33624 40 5 employed employ VERB bracis-33624 40 6 , , PUNCT bracis-33624 40 7 where where SCONJ bracis-33624 40 8 algorithms algorithm NOUN bracis-33624 40 9 are be AUX bracis-33624 40 10 trained train VERB bracis-33624 40 11 using use VERB bracis-33624 40 12 labeled label VERB bracis-33624 40 13 datasets dataset NOUN bracis-33624 40 14 to to PART bracis-33624 40 15 enable enable VERB bracis-33624 40 16 precise precise ADJ bracis-33624 40 17 classification classification NOUN bracis-33624 40 18 or or CCONJ bracis-33624 40 19 prediction prediction NOUN bracis-33624 40 20 . . PUNCT bracis-33624 41 1 specifically specifically ADV bracis-33624 41 2 , , PUNCT bracis-33624 41 3 regression regression NOUN bracis-33624 41 4 algorithms algorithm NOUN bracis-33624 41 5 have have AUX bracis-33624 41 6 been be AUX bracis-33624 41 7 utilized utilize VERB bracis-33624 41 8 to to PART bracis-33624 41 9 discern discern VERB bracis-33624 41 10 the the DET bracis-33624 41 11 most most ADV bracis-33624 41 12 significant significant ADJ bracis-33624 41 13 variables variable NOUN bracis-33624 41 14 in in ADP bracis-33624 41 15 extensive extensive ADJ bracis-33624 41 16 datasets dataset NOUN bracis-33624 41 17 comprising comprise VERB bracis-33624 41 18 hundreds hundred NOUN bracis-33624 41 19 or or CCONJ bracis-33624 41 20 thousands thousand NOUN bracis-33624 41 21 of of ADP bracis-33624 41 22 snps snps PROPN bracis-33624 42 1 [ [ X bracis-33624 42 2 16 16 NUM bracis-33624 42 3 ] ] PUNCT bracis-33624 42 4 . . PUNCT bracis-33624 43 1 this this DET bracis-33624 43 2 study study NOUN bracis-33624 43 3 harnesses harness NOUN bracis-33624 43 4 these these DET bracis-33624 43 5 supervised supervised ADJ bracis-33624 43 6 machine machine NOUN bracis-33624 43 7 learning learning NOUN bracis-33624 43 8 methods method NOUN bracis-33624 43 9 to to PART bracis-33624 43 10 predict predict VERB bracis-33624 43 11 alzheimer alzheimer PROPN bracis-33624 43 12 ’s ’s PART bracis-33624 43 13 disease disease NOUN bracis-33624 43 14 by by ADP bracis-33624 43 15 identifying identify VERB bracis-33624 43 16 pivotal pivotal ADJ bracis-33624 43 17 snps snps NOUN bracis-33624 43 18 . . PUNCT bracis-33624 44 1 this this DET bracis-33624 44 2 study study NOUN bracis-33624 44 3 also also ADV bracis-33624 44 4 focused focus VERB bracis-33624 44 5 on on ADP bracis-33624 44 6 explainability explainability NOUN bracis-33624 44 7 to to PART bracis-33624 44 8 identify identify VERB bracis-33624 44 9 the the DET bracis-33624 44 10 most most ADV bracis-33624 44 11 important important ADJ bracis-33624 44 12 features feature NOUN bracis-33624 44 13 , , PUNCT bracis-33624 44 14 known know VERB bracis-33624 44 15 as as ADP bracis-33624 44 16 single single ADJ bracis-33624 44 17 nucleotide nucleotide ADJ bracis-33624 44 18 polymorphisms polymorphism NOUN bracis-33624 44 19 ( ( PUNCT bracis-33624 44 20 snps snps PROPN bracis-33624 44 21 ) ) PUNCT bracis-33624 44 22 . . PUNCT bracis-33624 45 1 to to PART bracis-33624 45 2 achieve achieve VERB bracis-33624 45 3 this this PRON bracis-33624 45 4 , , PUNCT bracis-33624 45 5 several several ADJ bracis-33624 45 6 machine machine NOUN bracis-33624 45 7 learning learn VERB bracis-33624 45 8 algorithms algorithm NOUN bracis-33624 45 9 that that PRON bracis-33624 45 10 offer offer VERB bracis-33624 45 11 insights insight NOUN bracis-33624 45 12 into into ADP bracis-33624 45 13 feature feature NOUN bracis-33624 45 14 importance importance NOUN bracis-33624 45 15 were be AUX bracis-33624 45 16 used use VERB bracis-33624 45 17 , , PUNCT bracis-33624 45 18 including include VERB bracis-33624 45 19 random random ADJ bracis-33624 45 20 forest forest NOUN bracis-33624 45 21 , , PUNCT bracis-33624 45 22 xgboost xgboost ADV bracis-33624 45 23 , , PUNCT bracis-33624 45 24 and and CCONJ bracis-33624 45 25 logistic logistic ADJ bracis-33624 45 26 regression regression NOUN bracis-33624 45 27 . . PUNCT bracis-33624 46 1 these these DET bracis-33624 46 2 algorithms algorithm NOUN bracis-33624 46 3 were be AUX bracis-33624 46 4 applied apply VERB bracis-33624 46 5 to to ADP bracis-33624 46 6 the the DET bracis-33624 46 7 datasets dataset NOUN bracis-33624 46 8 to to PART bracis-33624 46 9 pinpoint pinpoint VERB bracis-33624 46 10 the the DET bracis-33624 46 11 most most ADV bracis-33624 46 12 significant significant ADJ bracis-33624 46 13 snps snps NOUN bracis-33624 46 14 , , PUNCT bracis-33624 46 15 based base VERB bracis-33624 46 16 on on ADP bracis-33624 46 17 their their PRON bracis-33624 46 18 feature feature NOUN bracis-33624 46 19 importance importance NOUN bracis-33624 46 20 scores score NOUN bracis-33624 46 21 [ [ X bracis-33624 46 22 17 17 NUM bracis-33624 46 23 ] ] PUNCT bracis-33624 46 24 . . PUNCT bracis-33624 47 1 both both DET bracis-33624 47 2 random random ADJ bracis-33624 47 3 forest forest NOUN bracis-33624 47 4 and and CCONJ bracis-33624 47 5 xgboost xgboost NOUN bracis-33624 47 6 are be AUX bracis-33624 47 7 renowned renowned ADJ bracis-33624 47 8 for for ADP bracis-33624 47 9 their their PRON bracis-33624 47 10 capability capability NOUN bracis-33624 47 11 to to PART bracis-33624 47 12 manage manage VERB bracis-33624 47 13 large large ADJ bracis-33624 47 14 datasets dataset NOUN bracis-33624 47 15 with with ADP bracis-33624 47 16 numerous numerous ADJ bracis-33624 47 17 features feature NOUN bracis-33624 47 18 , , PUNCT bracis-33624 47 19 such such ADJ bracis-33624 47 20 as as ADP bracis-33624 47 21 the the DET bracis-33624 47 22 genetic genetic ADJ bracis-33624 47 23 data datum NOUN bracis-33624 47 24 containing contain VERB bracis-33624 47 25 thousands thousand NOUN bracis-33624 47 26 of of ADP bracis-33624 47 27 single single ADJ bracis-33624 47 28 nucleotide nucleotide ADJ bracis-33624 47 29 polymorphisms polymorphism NOUN bracis-33624 47 30 ( ( PUNCT bracis-33624 47 31 snps snps PROPN bracis-33624 47 32 ) ) PUNCT bracis-33624 47 33 . . PUNCT bracis-33624 48 1 the the DET bracis-33624 48 2 configuration configuration NOUN bracis-33624 48 3 of of ADP bracis-33624 48 4 key key ADJ bracis-33624 48 5 parameters parameter NOUN bracis-33624 48 6 such such ADJ bracis-33624 48 7 as as ADP bracis-33624 48 8 maximum maximum ADJ bracis-33624 48 9 tree tree NOUN bracis-33624 48 10 depth depth NOUN bracis-33624 48 11 ( ( PUNCT bracis-33624 48 12 max_depth max_depth NOUN bracis-33624 48 13 ) ) PUNCT bracis-33624 48 14 , , PUNCT bracis-33624 48 15 number number NOUN bracis-33624 48 16 of of ADP bracis-33624 48 17 trees tree NOUN bracis-33624 48 18 ( ( PUNCT bracis-33624 48 19 n_estimators n_estimator NOUN bracis-33624 48 20 ) ) PUNCT bracis-33624 48 21 , , PUNCT bracis-33624 48 22 and and CCONJ bracis-33624 48 23 the the DET bracis-33624 48 24 maximum maximum ADJ bracis-33624 48 25 number number NOUN bracis-33624 48 26 of of ADP bracis-33624 48 27 features feature NOUN bracis-33624 48 28 considered consider VERB bracis-33624 48 29 for for ADP bracis-33624 48 30 splitting split VERB bracis-33624 48 31 a a DET bracis-33624 48 32 node node NOUN bracis-33624 48 33 ( ( PUNCT bracis-33624 48 34 max_features max_feature NOUN bracis-33624 48 35 ) ) PUNCT bracis-33624 48 36 significantly significantly ADV bracis-33624 48 37 impacts impact VERB bracis-33624 48 38 these these DET bracis-33624 48 39 models model NOUN bracis-33624 48 40 ’ ' PUNCT bracis-33624 48 41 ability ability NOUN bracis-33624 48 42 to to PART bracis-33624 48 43 detect detect VERB bracis-33624 48 44 intricate intricate ADJ bracis-33624 48 45 interactions interaction NOUN bracis-33624 48 46 among among ADP bracis-33624 48 47 snps snps PROPN bracis-33624 48 48 . . PUNCT bracis-33624 49 1 for for ADP bracis-33624 49 2 example example NOUN bracis-33624 49 3 , , PUNCT bracis-33624 49 4 increasing increase VERB bracis-33624 49 5 max_depth max_depth NOUN bracis-33624 49 6 enables enable VERB bracis-33624 49 7 the the DET bracis-33624 49 8 models model NOUN bracis-33624 49 9 to to PART bracis-33624 49 10 discern discern VERB bracis-33624 49 11 more more ADV bracis-33624 49 12 detailed detailed ADJ bracis-33624 49 13 patterns pattern NOUN bracis-33624 49 14 , , PUNCT bracis-33624 49 15 potentially potentially ADV bracis-33624 49 16 identifying identify VERB bracis-33624 49 17 complex complex ADJ bracis-33624 49 18 snp snp ADJ bracis-33624 49 19 interactions interaction NOUN bracis-33624 49 20 that that PRON bracis-33624 49 21 hold hold VERB bracis-33624 49 22 biological biological ADJ bracis-33624 49 23 relevance relevance NOUN bracis-33624 49 24 for for ADP bracis-33624 49 25 alzheimer alzheimer PROPN bracis-33624 49 26 ’s ’s PART bracis-33624 49 27 disease disease NOUN bracis-33624 49 28 ( ( PUNCT bracis-33624 49 29 ad ad NOUN bracis-33624 49 30 ) ) PUNCT bracis-33624 49 31 . . PUNCT bracis-33624 50 1 however however ADV bracis-33624 50 2 , , PUNCT bracis-33624 50 3 excessively excessively ADV bracis-33624 50 4 deep deep ADJ bracis-33624 50 5 trees tree NOUN bracis-33624 50 6 risk risk NOUN bracis-33624 50 7 overfitting overfitte VERB bracis-33624 50 8 , , PUNCT bracis-33624 50 9 capturing capture VERB bracis-33624 50 10 noise noise NOUN bracis-33624 50 11 rather rather ADV bracis-33624 50 12 than than ADP bracis-33624 50 13 valid valid ADJ bracis-33624 50 14 biological biological ADJ bracis-33624 50 15 signals signal NOUN bracis-33624 50 16 . . PUNCT bracis-33624 51 1 consequently consequently ADV bracis-33624 51 2 , , PUNCT bracis-33624 51 3 careful careful ADJ bracis-33624 51 4 tuning tuning NOUN bracis-33624 51 5 of of ADP bracis-33624 51 6 these these DET bracis-33624 51 7 parameters parameter NOUN bracis-33624 51 8 is be AUX bracis-33624 51 9 essential essential ADJ bracis-33624 51 10 to to PART bracis-33624 51 11 optimize optimize VERB bracis-33624 51 12 the the DET bracis-33624 51 13 balance balance NOUN bracis-33624 51 14 between between ADP bracis-33624 51 15 accuracy accuracy NOUN bracis-33624 51 16 and and CCONJ bracis-33624 51 17 generalization generalization NOUN bracis-33624 51 18 in in ADP bracis-33624 51 19 the the DET bracis-33624 51 20 models model NOUN bracis-33624 51 21 [ [ X bracis-33624 51 22 26 26 NUM bracis-33624 51 23 , , PUNCT bracis-33624 51 24 36 36 NUM bracis-33624 51 25 ] ] PUNCT bracis-33624 51 26 . . PUNCT bracis-33624 52 1 although although SCONJ bracis-33624 52 2 not not PART bracis-33624 52 3 as as ADV bracis-33624 52 4 commonly commonly ADV bracis-33624 52 5 utilized utilize VERB bracis-33624 52 6 as as ADP bracis-33624 52 7 tree tree NOUN bracis-33624 52 8 - - PUNCT bracis-33624 52 9 based base VERB bracis-33624 52 10 models model NOUN bracis-33624 52 11 in in ADP bracis-33624 52 12 genomic genomic ADJ bracis-33624 52 13 studies study NOUN bracis-33624 52 14 , , PUNCT bracis-33624 52 15 we we PRON bracis-33624 52 16 included include VERB bracis-33624 52 17 logistic logistic ADJ bracis-33624 52 18 regression regression NOUN bracis-33624 52 19 in in ADP bracis-33624 52 20 this this DET bracis-33624 52 21 study study NOUN bracis-33624 52 22 to to PART bracis-33624 52 23 compare compare VERB bracis-33624 52 24 and and CCONJ bracis-33624 52 25 analyze analyze VERB bracis-33624 52 26 its its PRON bracis-33624 52 27 predictive predictive ADJ bracis-33624 52 28 power power NOUN bracis-33624 52 29 . . PUNCT bracis-33624 53 1 this this DET bracis-33624 53 2 model model NOUN bracis-33624 53 3 was be AUX bracis-33624 53 4 enriched enrich VERB bracis-33624 53 5 by by ADP bracis-33624 53 6 tuning tune VERB bracis-33624 53 7 hyperparameters hyperparameter NOUN bracis-33624 53 8 such such ADJ bracis-33624 53 9 as as ADP bracis-33624 53 10 the the DET bracis-33624 53 11 penalty penalty NOUN bracis-33624 53 12 type type NOUN bracis-33624 53 13 ( ( PUNCT bracis-33624 53 14 penalty penalty NOUN bracis-33624 53 15 — — PUNCT bracis-33624 53 16 l1 l1 PROPN bracis-33624 53 17 , , PUNCT bracis-33624 53 18 l2 l2 NOUN bracis-33624 53 19 , , PUNCT bracis-33624 53 20 elasticnet elasticnet NOUN bracis-33624 53 21 ) ) PUNCT bracis-33624 53 22 and and CCONJ bracis-33624 53 23 regularization regularization NOUN bracis-33624 53 24 strength strength NOUN bracis-33624 53 25 ( ( PUNCT bracis-33624 53 26 c c NOUN bracis-33624 53 27 ) ) PUNCT bracis-33624 53 28 , , PUNCT bracis-33624 53 29 which which PRON bracis-33624 53 30 influence influence VERB bracis-33624 53 31 the the DET bracis-33624 53 32 model model NOUN bracis-33624 53 33 ’s ’s PART bracis-33624 53 34 sparsity sparsity NOUN bracis-33624 53 35 . . PUNCT bracis-33624 54 1 specifically specifically ADV bracis-33624 54 2 , , PUNCT bracis-33624 54 3 l1 l1 PROPN bracis-33624 54 4 regularization regularization NOUN bracis-33624 54 5 promotes promote VERB bracis-33624 54 6 feature feature NOUN bracis-33624 54 7 selection selection NOUN bracis-33624 54 8 by by ADP bracis-33624 54 9 zeroing zero VERB bracis-33624 54 10 out out ADP bracis-33624 54 11 less less ADV bracis-33624 54 12 important important ADJ bracis-33624 54 13 features feature NOUN bracis-33624 54 14 , , PUNCT bracis-33624 54 15 thereby thereby ADV bracis-33624 54 16 enabling enable VERB bracis-33624 54 17 the the DET bracis-33624 54 18 model model NOUN bracis-33624 54 19 to to PART bracis-33624 54 20 highlight highlight VERB bracis-33624 54 21 snps snps PROPN bracis-33624 54 22 most most ADV bracis-33624 54 23 predictive predictive NOUN bracis-33624 54 24 of of ADP bracis-33624 54 25 alzheimer alzheimer PROPN bracis-33624 54 26 ’s ’s PART bracis-33624 54 27 disease disease NOUN bracis-33624 54 28 ( ( PUNCT bracis-33624 54 29 ad ad NOUN bracis-33624 54 30 ) ) PUNCT bracis-33624 54 31 . . PUNCT bracis-33624 55 1 this this DET bracis-33624 55 2 approach approach NOUN bracis-33624 55 3 not not PART bracis-33624 55 4 only only ADV bracis-33624 55 5 simplifies simplify VERB bracis-33624 55 6 the the DET bracis-33624 55 7 genetic genetic ADJ bracis-33624 55 8 model model NOUN bracis-33624 55 9 but but CCONJ bracis-33624 55 10 also also ADV bracis-33624 55 11 focuses focus VERB bracis-33624 55 12 on on ADP bracis-33624 55 13 the the DET bracis-33624 55 14 most most ADV bracis-33624 55 15 biologically biologically ADV bracis-33624 55 16 relevant relevant ADJ bracis-33624 55 17 markers marker NOUN bracis-33624 55 18 . . PUNCT bracis-33624 56 1 the the DET bracis-33624 56 2 remainder remainder NOUN bracis-33624 56 3 of of ADP bracis-33624 56 4 this this DET bracis-33624 56 5 paper paper NOUN bracis-33624 56 6 is be AUX bracis-33624 56 7 organized organize VERB bracis-33624 56 8 as as SCONJ bracis-33624 56 9 follows follow VERB bracis-33624 56 10 : : PUNCT bracis-33624 56 11 sect sect NOUN bracis-33624 56 12 . . PUNCT bracis-33624 56 13     SPACE bracis-33624 57 1 2 2 NUM bracis-33624 57 2 presents present VERB bracis-33624 57 3 some some DET bracis-33624 57 4 related related ADJ bracis-33624 57 5 studies study NOUN bracis-33624 57 6 ; ; PUNCT bracis-33624 57 7 sect sect NOUN bracis-33624 57 8 . . PUNCT bracis-33624 57 9     SPACE bracis-33624 58 1 3 3 NUM bracis-33624 58 2 presents present VERB bracis-33624 58 3 our our PRON bracis-33624 58 4 proposed propose VERB bracis-33624 58 5 approach approach NOUN bracis-33624 58 6 ; ; PUNCT bracis-33624 58 7 sect sect NOUN bracis-33624 58 8 . . PUNCT bracis-33624 58 9     SPACE bracis-33624 59 1 4 4 NUM bracis-33624 59 2 presents present VERB bracis-33624 59 3 and and CCONJ bracis-33624 59 4 discusses discuss VERB bracis-33624 59 5 our our PRON bracis-33624 59 6 results result NOUN bracis-33624 59 7 ; ; PUNCT bracis-33624 59 8 and and CCONJ bracis-33624 59 9 finally finally ADV bracis-33624 59 10 , , PUNCT bracis-33624 59 11 sect sect NOUN bracis-33624 59 12 . . PUNCT bracis-33624 59 13     SPACE bracis-33624 60 1 5 5 NUM bracis-33624 60 2 presents present VERB bracis-33624 60 3 our our PRON bracis-33624 60 4 conclusions conclusion NOUN bracis-33624 60 5 and and CCONJ bracis-33624 60 6 future future ADJ bracis-33624 60 7     SPACE bracis-33624 60 8 works work NOUN bracis-33624 60 9 . . PUNCT bracis-33624 61 1 2 2 NUM bracis-33624 61 2 related relate VERB bracis-33624 61 3 work work NOUN bracis-33624 61 4 jin jin NOUN bracis-33624 61 5 et et PROPN bracis-33624 61 6 al al PROPN bracis-33624 61 7 . . PUNCT bracis-33624 62 1 [ [ X bracis-33624 62 2 18 18 NUM bracis-33624 62 3 ] ] PUNCT bracis-33624 62 4 conducted conduct VERB bracis-33624 62 5 a a DET bracis-33624 62 6 systematic systematic ADJ bracis-33624 62 7 exploration exploration NOUN bracis-33624 62 8 of of ADP bracis-33624 62 9 machine machine NOUN bracis-33624 62 10 learning learning NOUN bracis-33624 62 11 ( ( PUNCT bracis-33624 62 12 ml ml NOUN bracis-33624 62 13 ) ) PUNCT bracis-33624 62 14 and and CCONJ bracis-33624 62 15 deep deep ADJ bracis-33624 62 16 learning learning NOUN bracis-33624 62 17 ( ( PUNCT bracis-33624 62 18 dl dl NOUN bracis-33624 62 19 ) ) PUNCT bracis-33624 62 20 techniques technique NOUN bracis-33624 62 21 for for ADP bracis-33624 62 22 identifying identify VERB bracis-33624 62 23 and and CCONJ bracis-33624 62 24 analyzing analyze VERB bracis-33624 62 25 biomarkers biomarker NOUN bracis-33624 62 26 associated associate VERB bracis-33624 62 27 with with ADP bracis-33624 62 28 alzheimer alzheimer PROPN bracis-33624 62 29 ’s ’s PART bracis-33624 62 30 disease disease NOUN bracis-33624 62 31 . . PUNCT bracis-33624 63 1 their their PRON bracis-33624 63 2 review review NOUN bracis-33624 63 3 highlights highlight VERB bracis-33624 63 4 significant significant ADJ bracis-33624 63 5 research research NOUN bracis-33624 63 6 findings finding NOUN bracis-33624 63 7 , , PUNCT bracis-33624 63 8 such such ADJ bracis-33624 63 9 as as ADP bracis-33624 63 10 the the DET bracis-33624 63 11 use use NOUN bracis-33624 63 12 of of ADP bracis-33624 63 13 lasso lasso NOUN bracis-33624 63 14 for for ADP bracis-33624 63 15 feature feature NOUN bracis-33624 63 16 selection selection NOUN bracis-33624 63 17 [ [ X bracis-33624 63 18 39 39 NUM bracis-33624 63 19 ] ] PUNCT bracis-33624 63 20 , , PUNCT bracis-33624 63 21 and and CCONJ bracis-33624 63 22 identification identification NOUN bracis-33624 63 23 of of ADP bracis-33624 63 24 hub hub NOUN bracis-33624 63 25 genes gene NOUN bracis-33624 63 26 associated associate VERB bracis-33624 63 27 with with ADP bracis-33624 63 28 immune immune ADJ bracis-33624 63 29 function function NOUN bracis-33624 63 30 and and CCONJ bracis-33624 63 31 neuroinflammation neuroinflammation NOUN bracis-33624 63 32 [ [ X bracis-33624 63 33 40 40 NUM bracis-33624 63 34 ] ] PUNCT bracis-33624 63 35 . . PUNCT bracis-33624 64 1 the the DET bracis-33624 64 2 study study NOUN bracis-33624 64 3 showcases showcase VERB bracis-33624 64 4 notable notable ADJ bracis-33624 64 5 algorithms algorithm NOUN bracis-33624 64 6 like like ADP bracis-33624 64 7 differential differential ADJ bracis-33624 64 8 gene gene NOUN bracis-33624 64 9 selection selection NOUN bracis-33624 64 10 tabnet tabnet NOUN bracis-33624 64 11 for for ADP bracis-33624 64 12 effective effective ADJ bracis-33624 64 13 gene gene NOUN bracis-33624 64 14 - - PUNCT bracis-33624 64 15 based base VERB bracis-33624 64 16 classification classification NOUN bracis-33624 64 17 of of ADP bracis-33624 64 18 ad ad NOUN bracis-33624 64 19 . . PUNCT bracis-33624 65 1 the the DET bracis-33624 65 2 study study NOUN bracis-33624 65 3 conducted conduct VERB bracis-33624 65 4 by by ADP bracis-33624 65 5 araujo araujo PROPN bracis-33624 65 6 et et PROPN bracis-33624 65 7 al al PROPN bracis-33624 65 8 . . PUNCT bracis-33624 66 1 [ [ X bracis-33624 66 2 3 3 NUM bracis-33624 66 3 ] ] PUNCT bracis-33624 66 4 focuses focus VERB bracis-33624 66 5 on on ADP bracis-33624 66 6 the the DET bracis-33624 66 7 use use NOUN bracis-33624 66 8 of of ADP bracis-33624 66 9 random random ADJ bracis-33624 66 10 forest forest NOUN bracis-33624 66 11 algorithms algorithm NOUN bracis-33624 66 12 and and CCONJ bracis-33624 66 13 gene gene NOUN bracis-33624 66 14 network network NOUN bracis-33624 66 15 analysis analysis NOUN bracis-33624 66 16 to to PART bracis-33624 66 17 investigate investigate VERB bracis-33624 66 18 the the DET bracis-33624 66 19 correlations correlation NOUN bracis-33624 66 20 between between ADP bracis-33624 66 21 snps snps PROPN bracis-33624 66 22 and and CCONJ bracis-33624 66 23 alzheimer alzheimer PROPN bracis-33624 66 24 ’s ’s PART bracis-33624 66 25 disease disease NOUN bracis-33624 66 26 . . PUNCT bracis-33624 67 1 the the DET bracis-33624 67 2 research research NOUN bracis-33624 67 3 employs employ VERB bracis-33624 67 4 random random ADJ bracis-33624 67 5 forest forest NOUN bracis-33624 67 6 algorithms algorithm NOUN bracis-33624 67 7 due due ADP bracis-33624 67 8 to to ADP bracis-33624 67 9 its its PRON bracis-33624 67 10 effectiveness effectiveness NOUN bracis-33624 67 11 in in ADP bracis-33624 67 12 handling handle VERB bracis-33624 67 13 large large ADJ bracis-33624 67 14 datasets dataset NOUN bracis-33624 67 15 and and CCONJ bracis-33624 67 16 managing manage VERB bracis-33624 67 17 the the DET bracis-33624 67 18 complexity complexity NOUN bracis-33624 67 19 inherent inherent ADJ bracis-33624 67 20 in in ADP bracis-33624 67 21 genetic genetic ADJ bracis-33624 67 22 data datum NOUN bracis-33624 67 23 . . PUNCT bracis-33624 68 1 the the DET bracis-33624 68 2 study study NOUN bracis-33624 68 3 ’s ’s PART bracis-33624 68 4 findings finding NOUN bracis-33624 68 5 suggest suggest VERB bracis-33624 68 6 that that SCONJ bracis-33624 68 7 certain certain ADJ bracis-33624 68 8 snps snps PROPN bracis-33624 68 9 are be AUX bracis-33624 68 10 significantly significantly ADV bracis-33624 68 11 associated associate VERB bracis-33624 68 12 with with ADP bracis-33624 68 13 the the DET bracis-33624 68 14 disease disease NOUN bracis-33624 68 15 , , PUNCT bracis-33624 68 16 which which PRON bracis-33624 68 17 offers offer VERB bracis-33624 68 18 potential potential ADJ bracis-33624 68 19 new new ADJ bracis-33624 68 20 insights insight NOUN bracis-33624 68 21 into into ADP bracis-33624 68 22 its its PRON bracis-33624 68 23 genetic genetic ADJ bracis-33624 68 24 basis basis NOUN bracis-33624 68 25 . . PUNCT bracis-33624 69 1 a a DET bracis-33624 69 2 study study NOUN bracis-33624 69 3 by by ADP bracis-33624 69 4 sherif sherif PROPN bracis-33624 69 5 et et PROPN bracis-33624 69 6 al al PROPN bracis-33624 69 7 . . PUNCT bracis-33624 70 1 [ [ X bracis-33624 70 2 34 34 NUM bracis-33624 70 3 ] ] PUNCT bracis-33624 70 4 found find VERB bracis-33624 70 5 genetic genetic ADJ bracis-33624 70 6 variations variation NOUN bracis-33624 70 7 linked link VERB bracis-33624 70 8 with with ADP bracis-33624 70 9 alzheimer alzheimer PROPN bracis-33624 70 10 ’s ’s PART bracis-33624 70 11 disease disease NOUN bracis-33624 70 12 using use VERB bracis-33624 70 13 a a DET bracis-33624 70 14 multi multi ADJ bracis-33624 70 15 - - ADJ bracis-33624 70 16 stage stage ADJ bracis-33624 70 17 system system NOUN bracis-33624 70 18 . . PUNCT bracis-33624 71 1 they they PRON bracis-33624 71 2 used use VERB bracis-33624 71 3 a a DET bracis-33624 71 4 supervised supervised ADJ bracis-33624 71 5 bayesian bayesian NOUN bracis-33624 71 6 network network NOUN bracis-33624 71 7 and and CCONJ bracis-33624 71 8 discovered discover VERB bracis-33624 71 9 the the DET bracis-33624 71 10 most most ADV bracis-33624 71 11 ad ad NOUN bracis-33624 71 12 - - PUNCT bracis-33624 71 13 related relate VERB bracis-33624 71 14 snp snp NOUN bracis-33624 71 15 . . PUNCT bracis-33624 72 1 their their PRON bracis-33624 72 2 results result NOUN bracis-33624 72 3 showed show VERB bracis-33624 72 4 that that SCONJ bracis-33624 72 5 endothelial endothelial NOUN bracis-33624 72 6 - - PUNCT bracis-33624 72 7 based base VERB bracis-33624 72 8 markov markov NOUN bracis-33624 72 9 methods method NOUN bracis-33624 72 10 were be AUX bracis-33624 72 11 better well ADJ bracis-33624 72 12 than than ADP bracis-33624 72 13 naive naive ADJ bracis-33624 72 14 bayes baye NOUN bracis-33624 72 15 and and CCONJ bracis-33624 72 16 naive naive ADJ bracis-33624 72 17 tree tree NOUN bracis-33624 72 18 - - PUNCT bracis-33624 72 19 fed feed VERB bracis-33624 72 20 bayes bayes NOUN bracis-33624 72 21 , , PUNCT bracis-33624 72 22 but but CCONJ bracis-33624 72 23 their their PRON bracis-33624 72 24 work work NOUN bracis-33624 72 25 is be AUX bracis-33624 72 26 still still ADV bracis-33624 72 27 ongoing ongoing ADJ bracis-33624 72 28 in in ADP bracis-33624 72 29 drug drug NOUN bracis-33624 72 30 discovery discovery NOUN bracis-33624 72 31 . . PUNCT bracis-33624 73 1 [ [ X bracis-33624 73 2 2 2 NUM bracis-33624 73 3 ] ] PUNCT bracis-33624 73 4 study study NOUN bracis-33624 73 5 uses use VERB bracis-33624 73 6 machine machine NOUN bracis-33624 73 7 learning learn VERB bracis-33624 73 8 algorithms algorithm NOUN bracis-33624 73 9 to to PART bracis-33624 73 10 detect detect VERB bracis-33624 73 11 alzheimer alzheimer PROPN bracis-33624 73 12 ’s ’s PART bracis-33624 73 13 disease disease NOUN bracis-33624 73 14 early early ADV bracis-33624 73 15 by by ADP bracis-33624 73 16 analyzing analyze VERB bracis-33624 73 17 snps snps PROPN bracis-33624 73 18 . . PUNCT bracis-33624 74 1 the the DET bracis-33624 74 2 research research NOUN bracis-33624 74 3 focuses focus VERB bracis-33624 74 4 on on ADP bracis-33624 74 5 identifying identify VERB bracis-33624 74 6 genetic genetic ADJ bracis-33624 74 7 markers marker NOUN bracis-33624 74 8 predictive predictive ADJ bracis-33624 74 9 of of ADP bracis-33624 74 10 the the DET bracis-33624 74 11 disease disease NOUN bracis-33624 74 12 ’s ’s PART bracis-33624 74 13 early early ADJ bracis-33624 74 14 onset onset NOUN bracis-33624 74 15 . . PUNCT bracis-33624 75 1 the the DET bracis-33624 75 2 work work NOUN bracis-33624 75 3 showcases showcase VERB bracis-33624 75 4 the the DET bracis-33624 75 5 efficacy efficacy NOUN bracis-33624 75 6 of of ADP bracis-33624 75 7 combining combine VERB bracis-33624 75 8 detailed detailed ADJ bracis-33624 75 9 genetic genetic ADJ bracis-33624 75 10 data datum NOUN bracis-33624 75 11 with with ADP bracis-33624 75 12 precise precise ADJ bracis-33624 75 13 machine machine NOUN bracis-33624 75 14 learning learn VERB bracis-33624 75 15 techniques technique NOUN bracis-33624 75 16 to to PART bracis-33624 75 17 enhance enhance VERB bracis-33624 75 18 early early ADJ bracis-33624 75 19 detection detection NOUN bracis-33624 75 20 strategies strategy NOUN bracis-33624 75 21 . . PUNCT bracis-33624 76 1 our our PRON bracis-33624 76 2 study study NOUN bracis-33624 76 3 differs differ VERB bracis-33624 76 4 from from ADP bracis-33624 76 5 previous previous ADJ bracis-33624 76 6 research research NOUN bracis-33624 76 7 by by ADP bracis-33624 76 8 focusing focus VERB bracis-33624 76 9 solely solely ADV bracis-33624 76 10 on on ADP bracis-33624 76 11 genetic genetic ADJ bracis-33624 76 12 data datum NOUN bracis-33624 76 13 to to PART bracis-33624 76 14 identify identify VERB bracis-33624 76 15 markers marker NOUN bracis-33624 76 16 for for ADP bracis-33624 76 17 alzheimer alzheimer PROPN bracis-33624 76 18 ’s ’s PART bracis-33624 76 19 disease disease NOUN bracis-33624 76 20 ( ( PUNCT bracis-33624 76 21 ad ad NOUN bracis-33624 76 22 ) ) PUNCT bracis-33624 76 23 , , PUNCT bracis-33624 76 24 not not PART bracis-33624 76 25 including include VERB bracis-33624 76 26 environmental environmental ADJ bracis-33624 76 27 factors factor NOUN bracis-33624 76 28 and and CCONJ bracis-33624 76 29 pre pre ADJ bracis-33624 76 30 - - ADJ bracis-33624 76 31 filtered filter VERB bracis-33624 76 32 genetic genetic ADJ bracis-33624 76 33 markers marker NOUN bracis-33624 76 34 . . PUNCT bracis-33624 77 1 we we PRON bracis-33624 77 2 utilize utilize VERB bracis-33624 77 3 interpretable interpretable ADJ bracis-33624 77 4 models model NOUN bracis-33624 77 5 to to PART bracis-33624 77 6 ensure ensure VERB bracis-33624 77 7 transparency transparency NOUN bracis-33624 77 8 and and CCONJ bracis-33624 77 9 compare compare VERB bracis-33624 77 10 our our PRON bracis-33624 77 11 findings finding NOUN bracis-33624 77 12 with with ADP bracis-33624 77 13 blupf90 blupf90 NOUN bracis-33624 77 14 , , PUNCT bracis-33624 77 15 an an DET bracis-33624 77 16 advanced advanced ADJ bracis-33624 77 17 mixed mixed ADJ bracis-33624 77 18 linear linear ADJ bracis-33624 77 19 model model NOUN bracis-33624 77 20 approach approach NOUN bracis-33624 77 21 . . PUNCT bracis-33624 78 1 our our PRON bracis-33624 78 2 approach approach NOUN bracis-33624 78 3 emphasizes emphasize VERB bracis-33624 78 4 the the DET bracis-33624 78 5 impact impact NOUN bracis-33624 78 6 of of ADP bracis-33624 78 7 genetic genetic ADJ bracis-33624 78 8 data datum NOUN bracis-33624 78 9 on on ADP bracis-33624 78 10 advancing advance VERB bracis-33624 78 11 our our PRON bracis-33624 78 12 knowledge knowledge NOUN bracis-33624 78 13 of of ADP bracis-33624 78 14 ad ad NOUN bracis-33624 78 15 ’s ’s PART bracis-33624 78 16 genetic genetic ADJ bracis-33624 78 17 foundations foundation NOUN bracis-33624 78 18 and and CCONJ bracis-33624 78 19 supporting support VERB bracis-33624 78 20 the the DET bracis-33624 78 21 creation creation NOUN bracis-33624 78 22 of of ADP bracis-33624 78 23 precise precise ADJ bracis-33624 78 24 therapeutic therapeutic ADJ bracis-33624 78 25 and and CCONJ bracis-33624 78 26 diagnostic diagnostic ADJ bracis-33624 78 27 approaches approach NOUN bracis-33624 78 28 . . PUNCT bracis-33624 79 1 fig fig NOUN bracis-33624 79 2 . . PUNCT bracis-33624 80 1 1 1 X bracis-33624 80 2 . . X bracis-33624 80 3 methodology methodology NOUN bracis-33624 80 4 architecture architecture NOUN bracis-33624 80 5 full full ADJ bracis-33624 80 6 size size NOUN bracis-33624 80 7 image image NOUN bracis-33624 80 8 3 3 NUM bracis-33624 80 9 methods method NOUN bracis-33624 80 10 the the DET bracis-33624 80 11 methodology methodology NOUN bracis-33624 80 12 adopted adopt VERB bracis-33624 80 13 for for ADP bracis-33624 80 14 this this DET bracis-33624 80 15 study study NOUN bracis-33624 80 16 is be AUX bracis-33624 80 17 structured structure VERB bracis-33624 80 18 into into ADP bracis-33624 80 19 five five NUM bracis-33624 80 20 crucial crucial ADJ bracis-33624 80 21 stages stage NOUN bracis-33624 80 22 , , PUNCT bracis-33624 80 23 as as SCONJ bracis-33624 80 24 follows follow VERB bracis-33624 80 25 : : PUNCT bracis-33624 80 26 ( ( PUNCT bracis-33624 80 27 1 1 X bracis-33624 80 28 ) ) PUNCT bracis-33624 80 29 data datum NOUN bracis-33624 80 30 acquisition acquisition NOUN bracis-33624 80 31 ; ; PUNCT bracis-33624 80 32 ( ( PUNCT bracis-33624 80 33 2 2 X bracis-33624 80 34 ) ) PUNCT bracis-33624 80 35 data datum NOUN bracis-33624 80 36 processing processing NOUN bracis-33624 80 37 for for ADP bracis-33624 80 38 quality quality NOUN bracis-33624 80 39 control control NOUN bracis-33624 80 40 ; ; PUNCT bracis-33624 80 41 ( ( PUNCT bracis-33624 80 42 3 3 X bracis-33624 80 43 ) ) PUNCT bracis-33624 80 44 gwas gwas NOUN bracis-33624 80 45 using use VERB bracis-33624 80 46 blup blup PROPN bracis-33624 80 47 family family PROPN bracis-33624 80 48 of of ADP bracis-33624 80 49 programs program NOUN bracis-33624 80 50 ; ; PUNCT bracis-33624 80 51 ( ( PUNCT bracis-33624 80 52 4 4 X bracis-33624 80 53 ) ) PUNCT bracis-33624 80 54 employment employment NOUN bracis-33624 80 55 of of ADP bracis-33624 80 56 advanced advanced ADJ bracis-33624 80 57 machine machine NOUN bracis-33624 80 58 learning learn VERB bracis-33624 80 59 methods method NOUN bracis-33624 80 60 on on ADP bracis-33624 80 61 the the DET bracis-33624 80 62 dataset dataset NOUN bracis-33624 80 63 identified identify VERB bracis-33624 80 64 as as ADP bracis-33624 80 65 optimal optimal ADJ bracis-33624 80 66 in in ADP bracis-33624 80 67 the the DET bracis-33624 80 68 previous previous ADJ bracis-33624 80 69 phase phase NOUN bracis-33624 80 70 ; ; PUNCT bracis-33624 80 71 ( ( PUNCT bracis-33624 80 72 5 5 X bracis-33624 80 73 ) ) PUNCT bracis-33624 80 74 comparative comparative ADJ bracis-33624 80 75 analysis analysis NOUN bracis-33624 80 76 of of ADP bracis-33624 80 77 the the DET bracis-33624 80 78 results result NOUN bracis-33624 80 79 achieved achieve VERB bracis-33624 80 80 in in ADP bracis-33624 80 81 the the DET bracis-33624 80 82 gwas gwas NOUN bracis-33624 80 83 and and CCONJ bracis-33624 80 84 machine machine NOUN bracis-33624 80 85 learning learn VERB bracis-33624 80 86 stages stage NOUN bracis-33624 80 87 . . PUNCT bracis-33624 81 1 figure figure VERB bracis-33624 81 2     SPACE bracis-33624 81 3 1 1 NUM bracis-33624 81 4 schematizes schematize NOUN bracis-33624 81 5 the the DET bracis-33624 81 6 mentioned mention VERB bracis-33624 81 7 stages stage NOUN bracis-33624 81 8 and and CCONJ bracis-33624 81 9 their their PRON bracis-33624 81 10 respective respective ADJ bracis-33624 81 11 sub sub NOUN bracis-33624 81 12 - - NOUN bracis-33624 81 13 tasks task NOUN bracis-33624 81 14 , , PUNCT bracis-33624 81 15 which which PRON bracis-33624 81 16 will will AUX bracis-33624 81 17 be be AUX bracis-33624 81 18 detailed detail VERB bracis-33624 81 19 in in ADP bracis-33624 81 20 the the DET bracis-33624 81 21 subsequent subsequent ADJ bracis-33624 81 22 sections section NOUN bracis-33624 81 23 of of ADP bracis-33624 81 24 this this DET bracis-33624 81 25 article article NOUN bracis-33624 81 26 . . PUNCT bracis-33624 82 1 3.1 3.1 NUM bracis-33624 82 2 data datum NOUN bracis-33624 82 3 acquisition acquisition NOUN bracis-33624 82 4 the the DET bracis-33624 82 5 data datum NOUN bracis-33624 82 6 used use VERB bracis-33624 82 7 in in ADP bracis-33624 82 8 this this DET bracis-33624 82 9 study study NOUN bracis-33624 82 10 were be AUX bracis-33624 82 11 obtained obtain VERB bracis-33624 82 12 from from ADP bracis-33624 82 13 the the DET bracis-33624 82 14 alzheimer alzheimer PROPN bracis-33624 82 15 ’s ’s PART bracis-33624 82 16 disease disease NOUN bracis-33624 82 17 neuroimaging neuroimaging NOUN bracis-33624 82 18 initiative initiative NOUN bracis-33624 82 19 ( ( PUNCT bracis-33624 82 20 adni adni ADJ bracis-33624 82 21 ) ) PUNCT bracis-33624 82 22 database database NOUN bracis-33624 83 1 [ [ X bracis-33624 83 2 1 1 NUM bracis-33624 83 3 ] ] PUNCT bracis-33624 83 4 . . PUNCT bracis-33624 83 5 launched launch VERB bracis-33624 83 6 in in ADP bracis-33624 83 7 2004 2004 NUM bracis-33624 83 8 as as ADP bracis-33624 83 9 a a DET bracis-33624 83 10 public public ADJ bracis-33624 83 11 - - PUNCT bracis-33624 83 12 private private ADJ bracis-33624 83 13 partnership partnership NOUN bracis-33624 83 14 , , PUNCT bracis-33624 83 15 adni adni PROPN bracis-33624 83 16 aims aim VERB bracis-33624 83 17 to to PART bracis-33624 83 18 identify identify VERB bracis-33624 83 19 whether whether SCONJ bracis-33624 83 20 brain brain NOUN bracis-33624 83 21 images image NOUN bracis-33624 83 22 , , PUNCT bracis-33624 83 23 biological biological ADJ bracis-33624 83 24 markers marker NOUN bracis-33624 83 25 , , PUNCT bracis-33624 83 26 clinical clinical ADJ bracis-33624 83 27 evaluations evaluation NOUN bracis-33624 83 28 , , PUNCT bracis-33624 83 29 and and CCONJ bracis-33624 83 30 neuropsychological neuropsychological ADJ bracis-33624 83 31 assessments assessment NOUN bracis-33624 83 32 can can AUX bracis-33624 83 33 be be AUX bracis-33624 83 34 combined combine VERB bracis-33624 83 35 to to PART bracis-33624 83 36 measure measure VERB bracis-33624 83 37 the the DET bracis-33624 83 38 progression progression NOUN bracis-33624 83 39 of of ADP bracis-33624 83 40 mild mild ADJ bracis-33624 83 41 cognitive cognitive ADJ bracis-33624 83 42 impairment impairment NOUN bracis-33624 83 43 ( ( PUNCT bracis-33624 83 44 mci mci NOUN bracis-33624 83 45 ) ) PUNCT bracis-33624 83 46 and and CCONJ bracis-33624 83 47 alzheimer alzheimer PROPN bracis-33624 83 48 ’s ’s PART bracis-33624 83 49 disease disease NOUN bracis-33624 83 50 in in ADP bracis-33624 83 51 early early ADJ bracis-33624 83 52 stages stage NOUN bracis-33624 83 53 . . PUNCT bracis-33624 84 1 the the DET bracis-33624 84 2 initial initial ADJ bracis-33624 84 3 genotypic genotypic NOUN bracis-33624 84 4 data datum NOUN bracis-33624 84 5 contained contain VERB bracis-33624 84 6 620,901 620,901 NUM bracis-33624 84 7 variants variant NOUN bracis-33624 84 8 , , PUNCT bracis-33624 84 9 with with ADP bracis-33624 84 10 an an DET bracis-33624 84 11 average average NOUN bracis-33624 84 12 of of ADP bracis-33624 84 13 30,785 30,785 NUM bracis-33624 84 14 missing miss VERB bracis-33624 84 15 variants variant NOUN bracis-33624 84 16 . . PUNCT bracis-33624 85 1 the the DET bracis-33624 85 2 input input NOUN bracis-33624 85 3 file file NOUN bracis-33624 85 4 included include VERB bracis-33624 85 5 757 757 NUM bracis-33624 85 6 individuals individual NOUN bracis-33624 85 7 , , PUNCT bracis-33624 85 8 comprising comprise VERB bracis-33624 85 9 449 449 NUM bracis-33624 85 10 males male NOUN bracis-33624 85 11 and and CCONJ bracis-33624 85 12 308 308 NUM bracis-33624 85 13 females female NOUN bracis-33624 85 14 . . PUNCT bracis-33624 86 1 the the DET bracis-33624 86 2 phenotype phenotype NOUN bracis-33624 86 3 was be AUX bracis-33624 86 4 divided divide VERB bracis-33624 86 5 into into ADP bracis-33624 86 6 three three NUM bracis-33624 86 7 categories category NOUN bracis-33624 86 8 : : PUNCT bracis-33624 86 9 normal normal ADJ bracis-33624 86 10 ( ( PUNCT bracis-33624 86 11 cn cn PROPN bracis-33624 86 12 ) ) PUNCT bracis-33624 86 13 , , PUNCT bracis-33624 86 14 with with ADP bracis-33624 86 15 214 214 NUM bracis-33624 86 16 samples sample NOUN bracis-33624 86 17 ; ; PUNCT bracis-33624 86 18 alzheimer alzheimer PROPN bracis-33624 86 19 ’s ’s PART bracis-33624 86 20 disease disease NOUN bracis-33624 86 21 with with ADP bracis-33624 86 22 175 175 NUM bracis-33624 86 23 ; ; PUNCT bracis-33624 86 24 and and CCONJ bracis-33624 86 25 mild mild ADJ bracis-33624 86 26 cognitive cognitive ADJ bracis-33624 86 27 impairment impairment NOUN bracis-33624 86 28 ( ( PUNCT bracis-33624 86 29 mci mci NOUN bracis-33624 86 30 ) ) PUNCT bracis-33624 86 31 with with ADP bracis-33624 86 32 367 367 NUM bracis-33624 86 33 . . PUNCT bracis-33624 87 1 these these DET bracis-33624 87 2 categories category NOUN bracis-33624 87 3 were be AUX bracis-33624 87 4 estimated estimate VERB bracis-33624 87 5 by by ADP bracis-33624 87 6 adni adni NOUN bracis-33624 87 7 using use VERB bracis-33624 87 8 various various ADJ bracis-33624 87 9 biomarkers biomarker NOUN bracis-33624 87 10 , , PUNCT bracis-33624 87 11 which which PRON bracis-33624 87 12 are be AUX bracis-33624 87 13 substances substance NOUN bracis-33624 87 14 , , PUNCT bracis-33624 87 15 measurements measurement NOUN bracis-33624 87 16 , , PUNCT bracis-33624 87 17 or or CCONJ bracis-33624 87 18 indicators indicator NOUN bracis-33624 87 19 of of ADP bracis-33624 87 20 a a DET bracis-33624 87 21 biological biological ADJ bracis-33624 87 22 state state NOUN bracis-33624 87 23 that that PRON bracis-33624 87 24 can can AUX bracis-33624 87 25 be be AUX bracis-33624 87 26 identified identify VERB bracis-33624 87 27 before before ADP bracis-33624 87 28 the the DET bracis-33624 87 29 onset onset NOUN bracis-33624 87 30 of of ADP bracis-33624 87 31 clinical clinical ADJ bracis-33624 87 32 symptoms symptom NOUN bracis-33624 87 33 . . PUNCT bracis-33624 88 1 in in ADP bracis-33624 88 2 addition addition NOUN bracis-33624 88 3 to to ADP bracis-33624 88 4 genotypic genotypic ADJ bracis-33624 88 5 data datum NOUN bracis-33624 88 6 , , PUNCT bracis-33624 88 7 a a DET bracis-33624 88 8 dataset dataset NOUN bracis-33624 88 9 of of ADP bracis-33624 88 10 individual individual ADJ bracis-33624 88 11 phenotypes phenotype NOUN bracis-33624 88 12 was be AUX bracis-33624 88 13 also also ADV bracis-33624 88 14 obtained obtain VERB bracis-33624 88 15 . . PUNCT bracis-33624 89 1 this this DET bracis-33624 89 2 dataset dataset NOUN bracis-33624 89 3 contains contain VERB bracis-33624 89 4 information information NOUN bracis-33624 89 5 on on ADP bracis-33624 89 6 sex sex NOUN bracis-33624 89 7 , , PUNCT bracis-33624 89 8 age age NOUN bracis-33624 89 9 , , PUNCT bracis-33624 89 10 ethnicity ethnicity NOUN bracis-33624 89 11 , , PUNCT bracis-33624 89 12 and and CCONJ bracis-33624 89 13 gender gender NOUN bracis-33624 89 14 . . PUNCT bracis-33624 90 1 3.2 3.2 NUM bracis-33624 90 2 data datum NOUN bracis-33624 90 3 processing processing NOUN bracis-33624 90 4 for for ADP bracis-33624 90 5     SPACE bracis-33624 90 6 quality quality NOUN bracis-33624 90 7 control control NOUN bracis-33624 90 8 in in ADP bracis-33624 90 9 this this DET bracis-33624 90 10 study study NOUN bracis-33624 90 11 , , PUNCT bracis-33624 90 12 quality quality NOUN bracis-33624 90 13 control control NOUN bracis-33624 90 14 ( ( PUNCT bracis-33624 90 15 qc qc PROPN bracis-33624 90 16 ) ) PUNCT bracis-33624 90 17 methods method NOUN bracis-33624 90 18 preprocess preprocess VERB bracis-33624 90 19 the the DET bracis-33624 90 20 input input NOUN bracis-33624 90 21 data datum NOUN bracis-33624 90 22 for for ADP bracis-33624 90 23 genome genome NOUN bracis-33624 90 24 - - PUNCT bracis-33624 90 25 wide wide ADJ bracis-33624 90 26 association association NOUN bracis-33624 90 27 studies study NOUN bracis-33624 90 28 ( ( PUNCT bracis-33624 90 29 gwas gwas PROPN bracis-33624 90 30 ) ) PUNCT bracis-33624 90 31 . . PUNCT bracis-33624 91 1 the the DET bracis-33624 91 2 data datum NOUN bracis-33624 91 3 includes include VERB bracis-33624 91 4 individual individual ADJ bracis-33624 91 5 ids id NOUN bracis-33624 91 6 , , PUNCT bracis-33624 91 7 disease disease NOUN bracis-33624 91 8 stage stage NOUN bracis-33624 91 9 , , PUNCT bracis-33624 91 10 and and CCONJ bracis-33624 91 11 genotype genotype NOUN bracis-33624 91 12 information information NOUN bracis-33624 91 13 . . PUNCT bracis-33624 92 1 the the DET bracis-33624 92 2 employed employ VERB bracis-33624 92 3 qc qc PROPN bracis-33624 92 4 filters filter NOUN bracis-33624 92 5 include include VERB bracis-33624 92 6 minor minor ADJ bracis-33624 92 7 allele allele NOUN bracis-33624 92 8 frequency frequency NOUN bracis-33624 92 9 ( ( PUNCT bracis-33624 92 10 maf maf PROPN bracis-33624 92 11 ) ) PUNCT bracis-33624 92 12 , , PUNCT bracis-33624 92 13 which which PRON bracis-33624 92 14 excludes exclude VERB bracis-33624 92 15 snps snps PROPN bracis-33624 92 16 with with ADP bracis-33624 92 17 a a DET bracis-33624 92 18 maf maf NOUN bracis-33624 92 19 less less ADJ bracis-33624 92 20 than than ADP bracis-33624 92 21 certain certain ADJ bracis-33624 92 22 percentages percentage NOUN bracis-33624 92 23 to to PART bracis-33624 92 24 filter filter VERB bracis-33624 92 25 out out ADP bracis-33624 92 26 rare rare ADJ bracis-33624 92 27 variants variant NOUN bracis-33624 92 28 ; ; PUNCT bracis-33624 92 29 linkage linkage NOUN bracis-33624 92 30 disequilibrium disequilibrium NOUN bracis-33624 92 31 ( ( PUNCT bracis-33624 92 32 ld ld NOUN bracis-33624 92 33 ) ) PUNCT bracis-33624 92 34 for for ADP bracis-33624 92 35 detecting detect VERB bracis-33624 92 36 snp snp ADJ bracis-33624 92 37 clusters cluster NOUN bracis-33624 92 38 linked link VERB bracis-33624 92 39 to to ADP bracis-33624 92 40 specific specific ADJ bracis-33624 92 41 traits trait NOUN bracis-33624 92 42 ; ; PUNCT bracis-33624 92 43 hardy hardy ADJ bracis-33624 92 44 - - PUNCT bracis-33624 92 45 weinberg weinberg PROPN bracis-33624 92 46 equilibrium equilibrium NOUN bracis-33624 92 47 ( ( PUNCT bracis-33624 92 48 hwe hwe PROPN bracis-33624 92 49 ) ) PUNCT bracis-33624 92 50 to to PART bracis-33624 92 51 identify identify VERB bracis-33624 92 52 unusual unusual ADJ bracis-33624 92 53 allele allele NOUN bracis-33624 92 54 frequencies frequency NOUN bracis-33624 92 55 ; ; PUNCT bracis-33624 92 56 and and CCONJ bracis-33624 92 57 checks check NOUN bracis-33624 92 58 for for ADP bracis-33624 92 59 genotype genotype NOUN bracis-33624 92 60 and and CCONJ bracis-33624 92 61 sample sample NOUN bracis-33624 92 62 missingness missingness NOUN bracis-33624 92 63 , , PUNCT bracis-33624 92 64 removing remove VERB bracis-33624 92 65 entries entry NOUN bracis-33624 92 66 exceeding exceed VERB bracis-33624 92 67 predefined predefine VERB bracis-33624 92 68 thresholds threshold NOUN bracis-33624 92 69 . . PUNCT bracis-33624 93 1 these these DET bracis-33624 93 2 measures measure NOUN bracis-33624 93 3 are be AUX bracis-33624 93 4 crucial crucial ADJ bracis-33624 93 5 for for ADP bracis-33624 93 6 reducing reduce VERB bracis-33624 93 7 data datum NOUN bracis-33624 93 8 complexity complexity NOUN bracis-33624 93 9 and and CCONJ bracis-33624 93 10 improving improve VERB bracis-33624 93 11 the the DET bracis-33624 93 12 reliability reliability NOUN bracis-33624 93 13 of of ADP bracis-33624 93 14 the the DET bracis-33624 93 15 analysis analysis NOUN bracis-33624 93 16 . . PUNCT bracis-33624 94 1 3.3 3.3 NUM bracis-33624 94 2 best good ADJ bracis-33624 94 3 linear linear ADJ bracis-33624 94 4 unbiased unbiased ADJ bracis-33624 94 5 prediction prediction NOUN bracis-33624 94 6 ( ( PUNCT bracis-33624 94 7 blup blup PROPN bracis-33624 94 8 ) ) PUNCT bracis-33624 94 9 the the DET bracis-33624 94 10 best good ADJ bracis-33624 94 11 linear linear ADJ bracis-33624 94 12 unbiased unbiased ADJ bracis-33624 94 13 prediction prediction NOUN bracis-33624 94 14 ( ( PUNCT bracis-33624 94 15 blup blup NOUN bracis-33624 94 16 ) ) PUNCT bracis-33624 94 17 software software NOUN bracis-33624 94 18 suite suite NOUN bracis-33624 94 19 is be AUX bracis-33624 94 20 employed employ VERB bracis-33624 94 21 to to PART bracis-33624 94 22 select select VERB bracis-33624 94 23 the the DET bracis-33624 94 24 most most ADV bracis-33624 94 25 suitable suitable ADJ bracis-33624 94 26 dataset dataset NOUN bracis-33624 94 27 after after ADP bracis-33624 94 28 applying apply VERB bracis-33624 94 29 a a DET bracis-33624 94 30 series series NOUN bracis-33624 94 31 of of ADP bracis-33624 94 32 quality quality NOUN bracis-33624 94 33 control control NOUN bracis-33624 94 34 filters filter NOUN bracis-33624 94 35 . . PUNCT bracis-33624 95 1 the the DET bracis-33624 95 2 selected select VERB bracis-33624 95 3 dataset dataset NOUN bracis-33624 95 4 is be AUX bracis-33624 95 5 then then ADV bracis-33624 95 6 used use VERB bracis-33624 95 7 in in ADP bracis-33624 95 8 machine machine NOUN bracis-33624 95 9 learning learning NOUN bracis-33624 95 10 models model NOUN bracis-33624 95 11 to to PART bracis-33624 95 12 enhance enhance VERB bracis-33624 95 13 the the DET bracis-33624 95 14 study study NOUN bracis-33624 95 15 of of ADP bracis-33624 95 16 alzheimer alzheimer PROPN bracis-33624 95 17 ’s ’s PART bracis-33624 95 18 disease disease NOUN bracis-33624 95 19 , , PUNCT bracis-33624 95 20 focusing focus VERB bracis-33624 95 21 particularly particularly ADV bracis-33624 95 22 on on ADP bracis-33624 95 23 the the DET bracis-33624 95 24 significance significance NOUN bracis-33624 95 25 of of ADP bracis-33624 95 26 genetic genetic ADJ bracis-33624 95 27 markers marker NOUN bracis-33624 95 28 known know VERB bracis-33624 95 29 as as ADP bracis-33624 95 30 single single ADJ bracis-33624 95 31 nucleotide nucleotide ADJ bracis-33624 95 32 polymorphisms polymorphism NOUN bracis-33624 95 33 ( ( PUNCT bracis-33624 95 34 snps snps PROPN bracis-33624 95 35 ) ) PUNCT bracis-33624 95 36 . . PUNCT bracis-33624 96 1 these these DET bracis-33624 96 2 markers marker NOUN bracis-33624 96 3 are be AUX bracis-33624 96 4 analyzed analyze VERB bracis-33624 96 5 to to PART bracis-33624 96 6 understand understand VERB bracis-33624 96 7 their their PRON bracis-33624 96 8 influence influence NOUN bracis-33624 96 9 on on ADP bracis-33624 96 10 the the DET bracis-33624 96 11 disease disease NOUN bracis-33624 96 12 . . PUNCT bracis-33624 97 1 consequently consequently ADV bracis-33624 97 2 , , PUNCT bracis-33624 97 3 blup blup PROPN bracis-33624 97 4 serves serve VERB bracis-33624 97 5 two two NUM bracis-33624 97 6 primary primary ADJ bracis-33624 97 7 purposes purpose NOUN bracis-33624 97 8 in in ADP bracis-33624 97 9 this this DET bracis-33624 97 10 study study NOUN bracis-33624 97 11 : : PUNCT bracis-33624 97 12 firstly firstly ADV bracis-33624 97 13 , , PUNCT bracis-33624 97 14 to to PART bracis-33624 97 15 select select VERB bracis-33624 97 16 the the DET bracis-33624 97 17 best good ADJ bracis-33624 97 18 dataset dataset NOUN bracis-33624 97 19 based base VERB bracis-33624 97 20 on on ADP bracis-33624 97 21 a a DET bracis-33624 97 22 combination combination NOUN bracis-33624 97 23 of of ADP bracis-33624 97 24 qc qc PROPN bracis-33624 97 25 parameters parameter NOUN bracis-33624 97 26 , , PUNCT bracis-33624 97 27 and and CCONJ bracis-33624 97 28 secondly secondly ADV bracis-33624 97 29 , , PUNCT bracis-33624 97 30 to to PART bracis-33624 97 31 evaluate evaluate VERB bracis-33624 97 32 the the DET bracis-33624 97 33 significance significance NOUN bracis-33624 97 34 of of ADP bracis-33624 97 35 snps snps PROPN bracis-33624 97 36 through through ADP bracis-33624 97 37 its its PRON bracis-33624 97 38 predictive predictive ADJ bracis-33624 97 39 modeling modeling NOUN bracis-33624 97 40 capabilities capability NOUN bracis-33624 97 41 . . PUNCT bracis-33624 98 1 the the DET bracis-33624 98 2 blup blup PROPN bracis-33624 98 3 includes include VERB bracis-33624 98 4 several several ADJ bracis-33624 98 5 key key ADJ bracis-33624 98 6 programs program NOUN bracis-33624 98 7 , , PUNCT bracis-33624 98 8 each each PRON bracis-33624 98 9 playing play VERB bracis-33624 98 10 a a DET bracis-33624 98 11 vital vital ADJ bracis-33624 98 12 role role NOUN bracis-33624 98 13 in in ADP bracis-33624 98 14 the the DET bracis-33624 98 15 analysis analysis NOUN bracis-33624 98 16 , , PUNCT bracis-33624 98 17 being be AUX bracis-33624 98 18 them they PRON bracis-33624 98 19 : : PUNCT bracis-33624 98 20 a a X bracis-33624 98 21 ) ) PUNCT bracis-33624 98 22 runum runum NOUN bracis-33624 98 23 : : PUNCT bracis-33624 98 24 creates create VERB bracis-33624 98 25 necessary necessary ADJ bracis-33624 98 26 parameter parameter NOUN bracis-33624 98 27 files file NOUN bracis-33624 98 28 for for ADP bracis-33624 98 29 other other ADJ bracis-33624 98 30 software software NOUN bracis-33624 98 31 components component NOUN bracis-33624 98 32 . . PUNCT bracis-33624 99 1 b b X bracis-33624 99 2 ) ) PUNCT bracis-33624 99 3 thrgibbs1f90 thrgibbs1f90 NOUN bracis-33624 99 4 : : PUNCT bracis-33624 99 5 employs employ VERB bracis-33624 99 6 gibbs gibbs PROPN bracis-33624 99 7 sampling sample VERB bracis-33624 99 8 to to PART bracis-33624 99 9 estimate estimate VERB bracis-33624 99 10 important important ADJ bracis-33624 99 11 genetic genetic ADJ bracis-33624 99 12 variations variation NOUN bracis-33624 99 13 , , PUNCT bracis-33624 99 14 essential essential ADJ bracis-33624 99 15 for for ADP bracis-33624 99 16 analyzing analyze VERB bracis-33624 99 17 both both CCONJ bracis-33624 99 18 simple simple ADJ bracis-33624 99 19 and and CCONJ bracis-33624 99 20 complex complex ADJ bracis-33624 99 21 genetic genetic ADJ bracis-33624 99 22 traits trait NOUN bracis-33624 99 23 . . PUNCT bracis-33624 100 1 c c X bracis-33624 100 2 ) ) PUNCT bracis-33624 100 3 postgibbsf90 postgibbsf90 NOUN bracis-33624 100 4 : : PUNCT bracis-33624 100 5 summarizes summarize VERB bracis-33624 100 6 statistical statistical ADJ bracis-33624 100 7 samples sample NOUN bracis-33624 100 8 , , PUNCT bracis-33624 100 9 providing provide VERB bracis-33624 100 10 estimates estimate NOUN bracis-33624 100 11 of of ADP bracis-33624 100 12 genetic genetic ADJ bracis-33624 100 13 variation variation NOUN bracis-33624 100 14 . . PUNCT bracis-33624 101 1 d d X bracis-33624 101 2 ) ) PUNCT bracis-33624 101 3 blupf90 blupf90 NOUN bracis-33624 101 4 and and CCONJ bracis-33624 101 5 postgs postgs ADV bracis-33624 101 6 : : PUNCT bracis-33624 101 7 these these DET bracis-33624 101 8 programs program NOUN bracis-33624 101 9 calculate calculate VERB bracis-33624 101 10 p p NOUN bracis-33624 101 11 - - PUNCT bracis-33624 101 12 values value NOUN bracis-33624 101 13 for for ADP bracis-33624 101 14 each each DET bracis-33624 101 15 snp snp PROPN bracis-33624 101 16 , , PUNCT bracis-33624 101 17 identifying identify VERB bracis-33624 101 18 key key ADJ bracis-33624 101 19 genetic genetic ADJ bracis-33624 101 20 markers marker NOUN bracis-33624 101 21 for for ADP bracis-33624 101 22 alzheimer alzheimer PROPN bracis-33624 101 23 ’s ’s PART bracis-33624 101 24 disease disease NOUN bracis-33624 101 25 . . PUNCT bracis-33624 102 1 the the DET bracis-33624 102 2 genomic genomic ADJ bracis-33624 102 3 model model NOUN bracis-33624 102 4 . . PUNCT bracis-33624 103 1 the the DET bracis-33624 103 2 genetic genetic ADJ bracis-33624 103 3 analysis analysis NOUN bracis-33624 103 4 is be AUX bracis-33624 103 5 conducted conduct VERB bracis-33624 103 6 by by ADP bracis-33624 103 7 applying apply VERB bracis-33624 103 8 a a DET bracis-33624 103 9 genomic genomic ADJ bracis-33624 103 10 model model NOUN bracis-33624 103 11 that that PRON bracis-33624 103 12 predicts predict VERB bracis-33624 103 13 genetic genetic ADJ bracis-33624 103 14 susceptibility susceptibility NOUN bracis-33624 103 15 to to ADP bracis-33624 103 16 alzheimer alzheimer PROPN bracis-33624 103 17 ’s ’s PART bracis-33624 103 18 disease disease NOUN bracis-33624 103 19 based base VERB bracis-33624 103 20 on on ADP bracis-33624 103 21 snp snp ADJ bracis-33624 103 22 data datum NOUN bracis-33624 103 23 , , PUNCT bracis-33624 103 24 represented represent VERB bracis-33624 103 25 by by ADP bracis-33624 103 26 the the DET bracis-33624 103 27 equation equation NOUN bracis-33624 103 28 : : PUNCT bracis-33624 103 29 $ $ SYM bracis-33624 103 30 $ $ SYM bracis-33624 103 31 \begin{aligned \begin{aligne VERB bracis-33624 103 32 } } PUNCT bracis-33624 103 33 y y NOUN bracis-33624 103 34 = = PUNCT bracis-33624 103 35 x\beta x\beta PROPN bracis-33624 104 1 + + PUNCT bracis-33624 104 2 zu zu PROPN bracis-33624 104 3 + + CCONJ bracis-33624 104 4 e e X bracis-33624 104 5 \end{aligned}$$ \end{aligned}$$ X bracis-33624 104 6 ( ( PUNCT bracis-33624 104 7 1 1 NUM bracis-33624 104 8 ) ) PUNCT bracis-33624 104 9 where where SCONJ bracis-33624 104 10 : : PUNCT bracis-33624 104 11 y y PROPN bracis-33624 104 12 represents represent VERB bracis-33624 104 13 the the DET bracis-33624 104 14 observed observe VERB bracis-33624 104 15 traits trait NOUN bracis-33624 104 16 ( ( PUNCT bracis-33624 104 17 phenotypes phenotype NOUN bracis-33624 104 18 ) ) PUNCT bracis-33624 104 19 . . PUNCT bracis-33624 105 1 x x PUNCT bracis-33624 105 2 and and CCONJ bracis-33624 105 3 z z NOUN bracis-33624 105 4 are be AUX bracis-33624 105 5 matrices matrix NOUN bracis-33624 105 6 that that PRON bracis-33624 105 7 connect connect VERB bracis-33624 105 8 observations observation NOUN bracis-33624 105 9 to to ADP bracis-33624 105 10 fixed fix VERB bracis-33624 105 11 and and CCONJ bracis-33624 105 12 random random ADJ bracis-33624 105 13 effects effect NOUN bracis-33624 105 14 , , PUNCT bracis-33624 105 15 respectively respectively ADV bracis-33624 105 16 . . PUNCT bracis-33624 106 1 \(\beta \(\beta PROPN bracis-33624 106 2 \ \ PROPN bracis-33624 106 3 ) ) PUNCT bracis-33624 106 4 represents represent VERB bracis-33624 106 5 fixed fix VERB bracis-33624 106 6 effects effect NOUN bracis-33624 106 7 . . PUNCT bracis-33624 107 1 u u NOUN bracis-33624 107 2 is be AUX bracis-33624 107 3 a a DET bracis-33624 107 4 vector vector NOUN bracis-33624 107 5 of of ADP bracis-33624 107 6 random random ADJ bracis-33624 107 7 effects effect NOUN bracis-33624 107 8 . . PUNCT bracis-33624 108 1 e e NOUN bracis-33624 108 2 is be AUX bracis-33624 108 3 the the DET bracis-33624 108 4 error error NOUN bracis-33624 108 5 term term NOUN bracis-33624 108 6 . . PUNCT bracis-33624 109 1 this this DET bracis-33624 109 2 model model NOUN bracis-33624 109 3 facilitates facilitate VERB bracis-33624 109 4 the the DET bracis-33624 109 5 exploration exploration NOUN bracis-33624 109 6 of of ADP bracis-33624 109 7 how how SCONJ bracis-33624 109 8 specific specific ADJ bracis-33624 109 9 snps snps NOUN bracis-33624 109 10 may may AUX bracis-33624 109 11 be be AUX bracis-33624 109 12 associated associate VERB bracis-33624 109 13 with with ADP bracis-33624 109 14 alzheimer alzheimer PROPN bracis-33624 109 15 ’s ’s PART bracis-33624 109 16 disease disease NOUN bracis-33624 109 17 . . PUNCT bracis-33624 110 1 assessing assess VERB bracis-33624 110 2 significance significance NOUN bracis-33624 110 3 . . PUNCT bracis-33624 111 1 the the DET bracis-33624 111 2 significance significance NOUN bracis-33624 111 3 of of ADP bracis-33624 111 4 snp snp ADJ bracis-33624 111 5 associations association NOUN bracis-33624 111 6 is be AUX bracis-33624 111 7 quantified quantify VERB bracis-33624 111 8 through through ADP bracis-33624 111 9 p p NOUN bracis-33624 111 10 - - PUNCT bracis-33624 111 11 values value NOUN bracis-33624 111 12 , , PUNCT bracis-33624 111 13 which which PRON bracis-33624 111 14 evaluate evaluate VERB bracis-33624 111 15 the the DET bracis-33624 111 16 likelihood likelihood NOUN bracis-33624 111 17 that that SCONJ bracis-33624 111 18 the the DET bracis-33624 111 19 observed observed ADJ bracis-33624 111 20 genetic genetic ADJ bracis-33624 111 21 effects effect NOUN bracis-33624 111 22 are be AUX bracis-33624 111 23 due due ADJ bracis-33624 111 24 to to ADP bracis-33624 111 25 chance chance NOUN bracis-33624 111 26 . . PUNCT bracis-33624 112 1 lower low ADJ bracis-33624 112 2 p p NOUN bracis-33624 112 3 - - PUNCT bracis-33624 112 4 values value NOUN bracis-33624 112 5 indicate indicate VERB bracis-33624 112 6 a a DET bracis-33624 112 7 stronger strong ADJ bracis-33624 112 8 statistical statistical ADJ bracis-33624 112 9 connection connection NOUN bracis-33624 112 10 to to ADP bracis-33624 112 11 alzheimer alzheimer PROPN bracis-33624 112 12 ’s ’s PART bracis-33624 112 13 disease disease NOUN bracis-33624 112 14 , , PUNCT bracis-33624 112 15 suggesting suggest VERB bracis-33624 112 16 significant significant ADJ bracis-33624 112 17 roles role NOUN bracis-33624 112 18 for for ADP bracis-33624 112 19 certain certain ADJ bracis-33624 112 20 snps snps PROPN bracis-33624 112 21 in in ADP bracis-33624 112 22 its its PRON bracis-33624 112 23 development development NOUN bracis-33624 112 24 . . PUNCT bracis-33624 113 1 3.4 3.4 NUM bracis-33624 113 2 machine machine NOUN bracis-33624 113 3 learning learn VERB bracis-33624 113 4 algorithms algorithm NOUN bracis-33624 113 5 in in ADP bracis-33624 113 6 this this DET bracis-33624 113 7 study study NOUN bracis-33624 113 8 , , PUNCT bracis-33624 113 9 we we PRON bracis-33624 113 10 employed employ VERB bracis-33624 113 11 the the DET bracis-33624 113 12 algorithms algorithm NOUN bracis-33624 113 13 logistic logistic ADJ bracis-33624 113 14 regression regression NOUN bracis-33624 113 15 , , PUNCT bracis-33624 113 16 xgboost xgboost ADV bracis-33624 113 17 , , PUNCT bracis-33624 113 18 and and CCONJ bracis-33624 113 19 random random ADJ bracis-33624 113 20 forest forest NOUN bracis-33624 113 21 . . PUNCT bracis-33624 114 1 these these DET bracis-33624 114 2 models model NOUN bracis-33624 114 3 were be AUX bracis-33624 114 4 trained train VERB bracis-33624 114 5 using use VERB bracis-33624 114 6 a a DET bracis-33624 114 7 training training NOUN bracis-33624 114 8 set set NOUN bracis-33624 114 9 ( ( PUNCT bracis-33624 114 10 x_train x_train PROPN bracis-33624 114 11 , , PUNCT bracis-33624 114 12 y_train y_train X bracis-33624 114 13 ) ) PUNCT bracis-33624 114 14 consisting consist VERB bracis-33624 114 15 of of ADP bracis-33624 114 16 80 80 NUM bracis-33624 114 17 % % NOUN bracis-33624 114 18 labeled label VERB bracis-33624 114 19 data datum NOUN bracis-33624 114 20 for for ADP bracis-33624 114 21 alzheimer alzheimer PROPN bracis-33624 114 22 ’s ’s PART bracis-33624 114 23 disease disease NOUN bracis-33624 114 24 and and CCONJ bracis-33624 114 25 cognitively cognitively ADV bracis-33624 114 26 normal normal ADJ bracis-33624 114 27 and and CCONJ bracis-33624 114 28 then then ADV bracis-33624 114 29 internally internally ADV bracis-33624 114 30 validated validate VERB bracis-33624 114 31 using use VERB bracis-33624 114 32 the the DET bracis-33624 114 33 5 5 NUM bracis-33624 114 34 - - ADJ bracis-33624 114 35 fold fold ADJ bracis-33624 114 36 cross cross ADJ bracis-33624 114 37 - - ADJ bracis-33624 114 38 validation validation ADJ bracis-33624 114 39 technique technique NOUN bracis-33624 114 40 . . PUNCT bracis-33624 115 1 randomizedsearchcv randomizedsearchcv PROPN bracis-33624 115 2 was be AUX bracis-33624 115 3 utilized utilize VERB bracis-33624 115 4 to to PART bracis-33624 115 5 evaluate evaluate VERB bracis-33624 115 6 various various ADJ bracis-33624 115 7 hyperparameter hyperparameter NOUN bracis-33624 115 8 combinations combination NOUN bracis-33624 115 9 , , PUNCT bracis-33624 115 10 with with ADP bracis-33624 115 11 optimization optimization NOUN bracis-33624 115 12 based base VERB bracis-33624 115 13 on on ADP bracis-33624 115 14 the the DET bracis-33624 115 15 f1 f1 PROPN bracis-33624 115 16 scorer scorer NOUN bracis-33624 115 17 . . PUNCT bracis-33624 116 1 to to PART bracis-33624 116 2 prevent prevent VERB bracis-33624 116 3 any any DET bracis-33624 116 4 warnings warning NOUN bracis-33624 116 5 associated associate VERB bracis-33624 116 6 with with ADP bracis-33624 116 7 division division NOUN bracis-33624 116 8 by by ADP bracis-33624 116 9 zero zero NUM bracis-33624 116 10 in in ADP bracis-33624 116 11 the the DET bracis-33624 116 12 f1 f1 NOUN bracis-33624 116 13 score score NOUN bracis-33624 116 14 , , PUNCT bracis-33624 116 15 the the DET bracis-33624 116 16 zero_division zero_division NOUN bracis-33624 116 17 value value NOUN bracis-33624 116 18 was be AUX bracis-33624 116 19 set set VERB bracis-33624 116 20 to to ADP bracis-33624 116 21 1 1 NUM bracis-33624 116 22 . . PUNCT bracis-33624 117 1 finally finally ADV bracis-33624 117 2 , , PUNCT bracis-33624 117 3 the the DET bracis-33624 117 4 model model NOUN bracis-33624 117 5 was be AUX bracis-33624 117 6 externally externally ADV bracis-33624 117 7 evaluated evaluate VERB bracis-33624 117 8 on on ADP bracis-33624 117 9 the the DET bracis-33624 117 10 test test NOUN bracis-33624 117 11 set set NOUN bracis-33624 117 12 ( ( PUNCT bracis-33624 117 13 x_test x_test NUM bracis-33624 117 14 , , PUNCT bracis-33624 117 15 y_test y_test NUM bracis-33624 117 16 ) ) PUNCT bracis-33624 117 17 . . PUNCT bracis-33624 118 1 table table NOUN bracis-33624 118 2     SPACE bracis-33624 118 3 1 1 NUM bracis-33624 118 4 provides provide VERB bracis-33624 118 5 a a DET bracis-33624 118 6 comprehensive comprehensive ADJ bracis-33624 118 7 list list NOUN bracis-33624 118 8 of of ADP bracis-33624 118 9 all all DET bracis-33624 118 10 hyperparameters hyperparameter NOUN bracis-33624 118 11 used use VERB bracis-33624 118 12 for for ADP bracis-33624 118 13 fine fine ADV bracis-33624 118 14 - - PUNCT bracis-33624 118 15 tuning tuning NOUN bracis-33624 118 16 . . PUNCT bracis-33624 119 1 $ $ SYM bracis-33624 119 2 $ $ SYM bracis-33624 119 3 \begin{aligned \begin{aligne VERB bracis-33624 119 4 } } PUNCT bracis-33624 119 5 f_1 f_1 NOUN bracis-33624 119 6 = = SYM bracis-33624 119 7 2 2 NUM bracis-33624 119 8 \cdot \cdot NOUN bracis-33624 119 9 \frac{\text \frac{\text NOUN bracis-33624 119 10 { { PUNCT bracis-33624 119 11 precision precision NOUN bracis-33624 119 12 } } PUNCT bracis-33624 119 13 \cdot \cdot PROPN bracis-33624 119 14 \text \text NOUN bracis-33624 119 15 { { PUNCT bracis-33624 119 16 recall}}{\text recall}}{\text PROPN bracis-33624 119 17 { { PUNCT bracis-33624 119 18 precision precision NOUN bracis-33624 119 19 } } PUNCT bracis-33624 119 20 + + CCONJ bracis-33624 119 21 \text \text ADJ bracis-33624 119 22 { { PUNCT bracis-33624 119 23 recall recall NOUN bracis-33624 119 24 } } PUNCT bracis-33624 119 25 } } PUNCT bracis-33624 119 26 \end{aligned}$$ \end{aligned}$$ X bracis-33624 119 27 ( ( PUNCT bracis-33624 119 28 2 2 NUM bracis-33624 119 29 ) ) PUNCT bracis-33624 119 30 table table NOUN bracis-33624 119 31 1 1 NUM bracis-33624 119 32 . . PUNCT bracis-33624 119 33 hyperparameters hyperparameter NOUN bracis-33624 119 34 for for ADP bracis-33624 119 35 logistic logistic ADJ bracis-33624 119 36 regression regression NOUN bracis-33624 119 37 , , PUNCT bracis-33624 119 38 random random ADJ bracis-33624 119 39 forest forest NOUN bracis-33624 119 40 , , PUNCT bracis-33624 119 41 and and CCONJ bracis-33624 119 42 xgboostfull xgboostfull NOUN bracis-33624 119 43 size size NOUN bracis-33624 119 44 table table NOUN bracis-33624 119 45 for for ADP bracis-33624 119 46 logistic logistic ADJ bracis-33624 119 47 regression regression NOUN bracis-33624 119 48 , , PUNCT bracis-33624 119 49 we we PRON bracis-33624 119 50 adjusted adjust VERB bracis-33624 119 51 various various ADJ bracis-33624 119 52 settings setting NOUN bracis-33624 119 53 including include VERB bracis-33624 119 54 the the DET bracis-33624 119 55 regularization regularization NOUN bracis-33624 119 56 strength strength NOUN bracis-33624 119 57 ( ( PUNCT bracis-33624 119 58 c c NOUN bracis-33624 119 59 ) ) PUNCT bracis-33624 119 60 , , PUNCT bracis-33624 119 61 penalty penalty NOUN bracis-33624 119 62 type type NOUN bracis-33624 119 63 , , PUNCT bracis-33624 119 64 solver solver NOUN bracis-33624 119 65 used use VERB bracis-33624 119 66 , , PUNCT bracis-33624 119 67 and and CCONJ bracis-33624 119 68 the the DET bracis-33624 119 69 l1 l1 PROPN bracis-33624 119 70 ratio ratio NOUN bracis-33624 119 71 . . PUNCT bracis-33624 120 1 the the DET bracis-33624 120 2 random random ADJ bracis-33624 120 3 forest forest NOUN bracis-33624 120 4 model model NOUN bracis-33624 120 5 was be AUX bracis-33624 120 6 fine fine ADV bracis-33624 120 7 - - PUNCT bracis-33624 120 8 tuned tune VERB bracis-33624 120 9 by by ADP bracis-33624 120 10 adjusting adjust VERB bracis-33624 120 11 the the DET bracis-33624 120 12 number number NOUN bracis-33624 120 13 of of ADP bracis-33624 120 14 trees tree NOUN bracis-33624 120 15 , , PUNCT bracis-33624 120 16 their their PRON bracis-33624 120 17 maximum maximum ADJ bracis-33624 120 18 depth depth NOUN bracis-33624 120 19 , , PUNCT bracis-33624 120 20 and and CCONJ bracis-33624 120 21 the the DET bracis-33624 120 22 number number NOUN bracis-33624 120 23 of of ADP bracis-33624 120 24 features feature NOUN bracis-33624 120 25 considered consider VERB bracis-33624 120 26 at at ADP bracis-33624 120 27 each each DET bracis-33624 120 28 split split NOUN bracis-33624 120 29 to to PART bracis-33624 120 30 enhance enhance VERB bracis-33624 120 31 overall overall ADJ bracis-33624 120 32 performance performance NOUN bracis-33624 120 33 . . PUNCT bracis-33624 121 1 similarly similarly ADV bracis-33624 121 2 , , PUNCT bracis-33624 121 3 the the DET bracis-33624 121 4 xgboost xgboost PROPN bracis-33624 121 5 model model NOUN bracis-33624 121 6 was be AUX bracis-33624 121 7 adjusted adjust VERB bracis-33624 121 8 to to PART bracis-33624 121 9 prevent prevent VERB bracis-33624 121 10 overfitting overfitting NOUN bracis-33624 121 11 and and CCONJ bracis-33624 121 12 improve improve VERB bracis-33624 121 13 accuracy accuracy NOUN bracis-33624 121 14 by by ADP bracis-33624 121 15 optimizing optimize VERB bracis-33624 121 16 parameters parameter NOUN bracis-33624 121 17 like like ADP bracis-33624 121 18 the the DET bracis-33624 121 19 number number NOUN bracis-33624 121 20 of of ADP bracis-33624 121 21 trees tree NOUN bracis-33624 121 22 , , PUNCT bracis-33624 121 23 learning learning NOUN bracis-33624 121 24 rate rate NOUN bracis-33624 121 25 , , PUNCT bracis-33624 121 26 tree tree NOUN bracis-33624 121 27 depth depth NOUN bracis-33624 121 28 , , PUNCT bracis-33624 121 29 and and CCONJ bracis-33624 121 30 sampling sample VERB bracis-33624 121 31 methods method NOUN bracis-33624 121 32 . . PUNCT bracis-33624 122 1 3.5 3.5 NUM bracis-33624 122 2 gene gene NOUN bracis-33624 122 3 retrieval retrieval NOUN bracis-33624 122 4 this this DET bracis-33624 122 5 study study NOUN bracis-33624 122 6 retrieved retrieve VERB bracis-33624 122 7 gene gene NOUN bracis-33624 122 8 information information NOUN bracis-33624 122 9 using use VERB bracis-33624 122 10 biopython biopython PROPN bracis-33624 122 11 , , PUNCT bracis-33624 122 12 a a DET bracis-33624 122 13 tool tool NOUN bracis-33624 122 14 that that PRON bracis-33624 122 15 interfaces interface VERB bracis-33624 122 16 primarily primarily ADV bracis-33624 122 17 with with ADP bracis-33624 122 18 the the DET bracis-33624 122 19 national national ADJ bracis-33624 122 20 center center NOUN bracis-33624 122 21 for for ADP bracis-33624 122 22 biotechnology biotechnology NOUN bracis-33624 122 23 information information NOUN bracis-33624 122 24 ( ( PUNCT bracis-33624 122 25 ncbi ncbi NOUN bracis-33624 122 26 ) ) PUNCT bracis-33624 122 27 databases database NOUN bracis-33624 122 28 . . PUNCT bracis-33624 123 1 this this DET bracis-33624 123 2 approach approach NOUN bracis-33624 123 3 allowed allow VERB bracis-33624 123 4 for for ADP bracis-33624 123 5 the the DET bracis-33624 123 6 systematic systematic ADJ bracis-33624 123 7 extraction extraction NOUN bracis-33624 123 8 of of ADP bracis-33624 123 9 gene gene NOUN bracis-33624 123 10 data datum NOUN bracis-33624 123 11 based base VERB bracis-33624 123 12 on on ADP bracis-33624 123 13 specific specific ADJ bracis-33624 123 14 single single ADJ bracis-33624 123 15 nucleotide nucleotide NOUN bracis-33624 123 16 polymorphisms polymorphism NOUN bracis-33624 123 17 ( ( PUNCT bracis-33624 123 18 snps snps PROPN bracis-33624 123 19 ) ) PUNCT bracis-33624 123 20 . . PUNCT bracis-33624 124 1 the the DET bracis-33624 124 2 identified identify VERB bracis-33624 124 3 genes gene NOUN bracis-33624 124 4 were be AUX bracis-33624 124 5 compared compare VERB bracis-33624 124 6 to to ADP bracis-33624 124 7 the the DET bracis-33624 124 8 ones one NOUN bracis-33624 124 9 present present ADJ bracis-33624 124 10 in in ADP bracis-33624 124 11 the the DET bracis-33624 124 12 existing exist VERB bracis-33624 124 13 literature literature NOUN bracis-33624 124 14 about about ADP bracis-33624 124 15 alzheimer alzheimer PROPN bracis-33624 124 16 ’s ’s PART bracis-33624 124 17     SPACE bracis-33624 124 18 disease disease NOUN bracis-33624 124 19 . . PUNCT bracis-33624 125 1 this this DET bracis-33624 125 2 study study NOUN bracis-33624 125 3 used use VERB bracis-33624 125 4 data datum NOUN bracis-33624 125 5 sourced source VERB bracis-33624 125 6 from from ADP bracis-33624 125 7 the the DET bracis-33624 125 8 alzheimer alzheimer PROPN bracis-33624 125 9 ’s ’s PART bracis-33624 125 10 disease disease NOUN bracis-33624 125 11 neuroimaging neuroimaging NOUN bracis-33624 125 12 initiative initiative NOUN bracis-33624 125 13 ( ( PUNCT bracis-33624 125 14 adni adni NOUN bracis-33624 125 15 ) ) PUNCT bracis-33624 125 16 , , PUNCT bracis-33624 125 17 where where SCONJ bracis-33624 125 18 participant participant ADJ bracis-33624 125 19 information information NOUN bracis-33624 125 20 is be AUX bracis-33624 125 21 pre pre ADJ bracis-33624 125 22 - - VERB bracis-33624 125 23 anonymized anonymized ADJ bracis-33624 125 24 to to PART bracis-33624 125 25 protect protect VERB bracis-33624 125 26 privacy privacy NOUN bracis-33624 125 27 . . PUNCT bracis-33624 126 1 our our PRON bracis-33624 126 2 access access NOUN bracis-33624 126 3 to to ADP bracis-33624 126 4 and and CCONJ bracis-33624 126 5 use use NOUN bracis-33624 126 6 of of ADP bracis-33624 126 7 this this DET bracis-33624 126 8 data datum NOUN bracis-33624 126 9 strictly strictly ADV bracis-33624 126 10 adhered adhere VERB bracis-33624 126 11 to to ADP bracis-33624 126 12 all all DET bracis-33624 126 13 guidelines guideline NOUN bracis-33624 126 14 provided provide VERB bracis-33624 126 15 by by ADP bracis-33624 126 16 adni adni PROPN bracis-33624 126 17 , , PUNCT bracis-33624 126 18 which which PRON bracis-33624 126 19 are be AUX bracis-33624 126 20 designed design VERB bracis-33624 126 21 to to PART bracis-33624 126 22 comply comply VERB bracis-33624 126 23 with with ADP bracis-33624 126 24 ethical ethical ADJ bracis-33624 126 25 standards standard NOUN bracis-33624 126 26 for for ADP bracis-33624 126 27 research research NOUN bracis-33624 126 28 involving involve VERB bracis-33624 126 29 human human ADJ bracis-33624 126 30 subjects subject NOUN bracis-33624 126 31 . . PUNCT bracis-33624 127 1 since since SCONJ bracis-33624 127 2 the the DET bracis-33624 127 3 data datum NOUN bracis-33624 127 4 was be AUX bracis-33624 127 5 pre pre ADJ bracis-33624 127 6 - - VERB bracis-33624 127 7 anonymized anonymized ADJ bracis-33624 127 8 and and CCONJ bracis-33624 127 9 publicly publicly ADV bracis-33624 127 10 available available ADJ bracis-33624 127 11 , , PUNCT bracis-33624 127 12 this this DET bracis-33624 127 13 study study NOUN bracis-33624 127 14 did do AUX bracis-33624 127 15 not not PART bracis-33624 127 16 require require VERB bracis-33624 127 17 additional additional ADJ bracis-33624 127 18 ethical ethical ADJ bracis-33624 127 19 approval approval NOUN bracis-33624 127 20 from from ADP bracis-33624 127 21 an an DET bracis-33624 127 22 ethics ethic NOUN bracis-33624 127 23 committee committee NOUN bracis-33624 127 24 . . PUNCT bracis-33624 128 1 4 4 NUM bracis-33624 128 2 results result NOUN bracis-33624 128 3 and and CCONJ bracis-33624 128 4     SPACE bracis-33624 128 5 discussion discussion NOUN bracis-33624 128 6 4.1 4.1 NUM bracis-33624 128 7 data datum NOUN bracis-33624 128 8 quality quality NOUN bracis-33624 128 9 control control NOUN bracis-33624 128 10 to to PART bracis-33624 128 11 ensure ensure VERB bracis-33624 128 12 optimal optimal ADJ bracis-33624 128 13 results result NOUN bracis-33624 128 14 , , PUNCT bracis-33624 128 15 a a DET bracis-33624 128 16 quality quality NOUN bracis-33624 128 17 control control NOUN bracis-33624 128 18 standard standard NOUN bracis-33624 128 19 was be AUX bracis-33624 128 20 implemented implement VERB bracis-33624 128 21 , , PUNCT bracis-33624 128 22 which which PRON bracis-33624 128 23 included include VERB bracis-33624 128 24 a a DET bracis-33624 128 25 minor minor ADJ bracis-33624 128 26 allele allele NOUN bracis-33624 128 27 frequency frequency NOUN bracis-33624 128 28 ( ( PUNCT bracis-33624 128 29 maf maf PROPN bracis-33624 128 30 ) ) PUNCT bracis-33624 128 31 of of ADP bracis-33624 128 32 0.01 0.01 NUM bracis-33624 128 33 , , PUNCT bracis-33624 128 34 a a DET bracis-33624 128 35 linkage linkage NOUN bracis-33624 128 36 disequilibrium disequilibrium NOUN bracis-33624 128 37 ( ( PUNCT bracis-33624 128 38 ld ld NOUN bracis-33624 128 39 ) ) PUNCT bracis-33624 128 40 threshold threshold NOUN bracis-33624 128 41 of of ADP bracis-33624 128 42 85 85 NUM bracis-33624 128 43 , , PUNCT bracis-33624 128 44 a a DET bracis-33624 128 45 hardy hardy ADJ bracis-33624 128 46 - - PUNCT bracis-33624 128 47 weinberg weinberg NOUN bracis-33624 128 48 equilibrium equilibrium NOUN bracis-33624 128 49 ( ( PUNCT bracis-33624 128 50 hwe hwe PROPN bracis-33624 128 51 ) ) PUNCT bracis-33624 128 52 significance significance NOUN bracis-33624 128 53 of of ADP bracis-33624 128 54 5e-6 5e-6 PROPN bracis-33624 128 55 , , PUNCT bracis-33624 128 56 a a DET bracis-33624 128 57 sample sample NOUN bracis-33624 128 58 missingness missingness NOUN bracis-33624 128 59 rate rate NOUN bracis-33624 128 60 of of ADP bracis-33624 128 61 0.01 0.01 NUM bracis-33624 128 62 , , PUNCT bracis-33624 128 63 and and CCONJ bracis-33624 128 64 a a DET bracis-33624 128 65 gene gene NOUN bracis-33624 128 66 missingness missingness NOUN bracis-33624 128 67 rate rate NOUN bracis-33624 128 68 of of ADP bracis-33624 128 69 0.1 0.1 NUM bracis-33624 128 70 . . PUNCT bracis-33624 129 1 the the DET bracis-33624 129 2 snp snp PROPN bracis-33624 129 3 rs7918269 rs7918269 PROPN bracis-33624 129 4 produced produce VERB bracis-33624 129 5 the the DET bracis-33624 129 6 most most ADV bracis-33624 129 7 significant significant ADJ bracis-33624 129 8 outcome outcome NOUN bracis-33624 129 9 , , PUNCT bracis-33624 129 10 with with ADP bracis-33624 129 11 a a DET bracis-33624 129 12 p p NOUN bracis-33624 129 13 - - PUNCT bracis-33624 129 14 value value NOUN bracis-33624 129 15 of of ADP bracis-33624 129 16 1.600000e-09 1.600000e-09 NUM bracis-33624 129 17 . . PUNCT bracis-33624 130 1 please please INTJ bracis-33624 130 2 note note VERB bracis-33624 130 3 that that SCONJ bracis-33624 130 4 the the DET bracis-33624 130 5 qc qc PROPN bracis-33624 130 6 hyperparameters hyperparameter NOUN bracis-33624 130 7 can can AUX bracis-33624 130 8 impact impact VERB bracis-33624 130 9 the the DET bracis-33624 130 10 results result NOUN bracis-33624 130 11 , , PUNCT bracis-33624 130 12 and and CCONJ bracis-33624 130 13 thus thus ADV bracis-33624 130 14 , , PUNCT bracis-33624 130 15 selecting select VERB bracis-33624 130 16 the the DET bracis-33624 130 17 ideal ideal ADJ bracis-33624 130 18 hyperparameters hyperparameter NOUN bracis-33624 130 19 is be AUX bracis-33624 130 20 crucial crucial ADJ bracis-33624 130 21 for for ADP bracis-33624 130 22 achieving achieve VERB bracis-33624 130 23 optimal optimal ADJ bracis-33624 130 24 outcomes outcome NOUN bracis-33624 130 25 . . PUNCT bracis-33624 131 1 4.2 4.2 NUM bracis-33624 131 2 machine machine NOUN bracis-33624 131 3 learning learn VERB bracis-33624 131 4 hyperparameter hyperparameter NOUN bracis-33624 131 5 selection selection NOUN bracis-33624 131 6 in in ADP bracis-33624 131 7 this this DET bracis-33624 131 8 study study NOUN bracis-33624 131 9 , , PUNCT bracis-33624 131 10 tuning tuning NOUN bracis-33624 131 11 of of ADP bracis-33624 131 12 hyperparameters hyperparameter NOUN bracis-33624 131 13 was be AUX bracis-33624 131 14 critical critical ADJ bracis-33624 131 15 to to PART bracis-33624 131 16 optimize optimize VERB bracis-33624 131 17 each each DET bracis-33624 131 18 machine machine NOUN bracis-33624 131 19 learning learn VERB bracis-33624 131 20 model model PROPN bracis-33624 131 21 ’s ’s PART bracis-33624 131 22 performance performance NOUN bracis-33624 131 23 for for ADP bracis-33624 131 24 predicting predict VERB bracis-33624 131 25 alzheimer alzheimer PROPN bracis-33624 131 26 ’s ’s PART bracis-33624 131 27 disease disease NOUN bracis-33624 131 28 using use VERB bracis-33624 131 29 snps snps PROPN bracis-33624 131 30 . . PUNCT bracis-33624 132 1 table table NOUN bracis-33624 132 2     SPACE bracis-33624 132 3 3 3 NUM bracis-33624 132 4 illustrates illustrate VERB bracis-33624 132 5 the the DET bracis-33624 132 6 selected select VERB bracis-33624 132 7 hyperparameter hyperparameter NOUN bracis-33624 132 8 settings setting NOUN bracis-33624 132 9 for for ADP bracis-33624 132 10 the the DET bracis-33624 132 11 logistic logistic ADJ bracis-33624 132 12 regression regression NOUN bracis-33624 132 13 , , PUNCT bracis-33624 132 14 random random ADJ bracis-33624 132 15 forest forest NOUN bracis-33624 132 16 , , PUNCT bracis-33624 132 17 and and CCONJ bracis-33624 132 18 xgboost xgboost ADV bracis-33624 132 19 algorithms algorithm NOUN bracis-33624 132 20 , , PUNCT bracis-33624 132 21 ensuring ensure VERB bracis-33624 132 22 each each DET bracis-33624 132 23 model model NOUN bracis-33624 132 24 ’s ’s PART bracis-33624 132 25 efficacy efficacy NOUN bracis-33624 132 26 and and CCONJ bracis-33624 132 27 robustness robustness NOUN bracis-33624 132 28 . . PUNCT bracis-33624 133 1 4.3 4.3 NUM bracis-33624 133 2 prediction prediction NOUN bracis-33624 133 3 performance performance NOUN bracis-33624 133 4 analysis analysis NOUN bracis-33624 133 5 although although SCONJ bracis-33624 133 6 the the DET bracis-33624 133 7 predictive predictive ADJ bracis-33624 133 8 performance performance NOUN bracis-33624 133 9 of of ADP bracis-33624 133 10 the the DET bracis-33624 133 11 models model NOUN bracis-33624 133 12 was be AUX bracis-33624 133 13 not not PART bracis-33624 133 14 the the DET bracis-33624 133 15 primary primary ADJ bracis-33624 133 16 focus focus NOUN bracis-33624 133 17 of of ADP bracis-33624 133 18 this this DET bracis-33624 133 19 study study NOUN bracis-33624 133 20 , , PUNCT bracis-33624 133 21 their their PRON bracis-33624 133 22 ability ability NOUN bracis-33624 133 23 to to PART bracis-33624 133 24 make make VERB bracis-33624 133 25 accurate accurate ADJ bracis-33624 133 26 predictions prediction NOUN bracis-33624 133 27 was be AUX bracis-33624 133 28 analyzed analyze VERB bracis-33624 133 29 . . PUNCT bracis-33624 134 1 overall overall ADV bracis-33624 134 2 , , PUNCT bracis-33624 134 3 the the DET bracis-33624 134 4 models model NOUN bracis-33624 134 5 demonstrated demonstrate VERB bracis-33624 134 6 similar similar ADJ bracis-33624 134 7 accuracy accuracy NOUN bracis-33624 134 8 but but CCONJ bracis-33624 134 9 exhibited exhibit VERB bracis-33624 134 10 significant significant ADJ bracis-33624 134 11 differences difference NOUN bracis-33624 134 12 in in ADP bracis-33624 134 13 precision precision NOUN bracis-33624 134 14 and and CCONJ bracis-33624 134 15 recall recall NOUN bracis-33624 134 16 . . PUNCT bracis-33624 135 1 the the DET bracis-33624 135 2 random random ADJ bracis-33624 135 3 forest forest NOUN bracis-33624 135 4 model model NOUN bracis-33624 135 5 had have VERB bracis-33624 135 6 higher high ADJ bracis-33624 135 7 precision precision NOUN bracis-33624 135 8 but but CCONJ bracis-33624 135 9 lower low ADJ bracis-33624 135 10 recall recall NOUN bracis-33624 135 11 compared compare VERB bracis-33624 135 12 to to ADP bracis-33624 135 13 the the DET bracis-33624 135 14 other other ADJ bracis-33624 135 15 models model NOUN bracis-33624 135 16 , , PUNCT bracis-33624 135 17 indicating indicate VERB bracis-33624 135 18 a a DET bracis-33624 135 19 tendency tendency NOUN bracis-33624 135 20 to to PART bracis-33624 135 21 frequently frequently ADV bracis-33624 135 22 predict predict VERB bracis-33624 135 23 the the DET bracis-33624 135 24 negative negative ADJ bracis-33624 135 25 class class NOUN bracis-33624 135 26 ( ( PUNCT bracis-33624 135 27 cn cn PROPN bracis-33624 135 28 ) ) PUNCT bracis-33624 135 29 . . PUNCT bracis-33624 136 1 logistic logistic ADJ bracis-33624 136 2 regression regression NOUN bracis-33624 136 3 and and CCONJ bracis-33624 136 4 xgboost xgboost NOUN bracis-33624 136 5 performed perform VERB bracis-33624 136 6 better well ADV bracis-33624 136 7 in in ADP bracis-33624 136 8 maintaining maintain VERB bracis-33624 136 9 a a DET bracis-33624 136 10 balance balance NOUN bracis-33624 136 11 between between ADP bracis-33624 136 12 precision precision NOUN bracis-33624 136 13 and and CCONJ bracis-33624 136 14 recall recall NOUN bracis-33624 136 15 , , PUNCT bracis-33624 136 16 with with ADP bracis-33624 136 17 xgboost xgboost ADV bracis-33624 136 18 slightly slightly ADV bracis-33624 136 19 outperforming outperforming NOUN bracis-33624 136 20 . . PUNCT bracis-33624 137 1 however however ADV bracis-33624 137 2 , , PUNCT bracis-33624 137 3 all all DET bracis-33624 137 4 models model NOUN bracis-33624 137 5 have have VERB bracis-33624 137 6 room room NOUN bracis-33624 137 7 for for ADP bracis-33624 137 8 improvement improvement NOUN bracis-33624 137 9 , , PUNCT bracis-33624 137 10 especially especially ADV bracis-33624 137 11 in in ADP bracis-33624 137 12 terms term NOUN bracis-33624 137 13 of of ADP bracis-33624 137 14 balancing balance VERB bracis-33624 137 15 performance performance NOUN bracis-33624 137 16 metrics metric NOUN bracis-33624 137 17 . . PUNCT bracis-33624 138 1 the the DET bracis-33624 138 2 detailed detailed ADJ bracis-33624 138 3 results result NOUN bracis-33624 138 4 obtained obtain VERB bracis-33624 138 5 from from ADP bracis-33624 138 6 the the DET bracis-33624 138 7 machine machine NOUN bracis-33624 138 8 learning learning NOUN bracis-33624 138 9 models model NOUN bracis-33624 138 10 are be AUX bracis-33624 138 11 described describe VERB bracis-33624 138 12 as as SCONJ bracis-33624 138 13 follows follow VERB bracis-33624 138 14 : : PUNCT bracis-33624 138 15 random random ADJ bracis-33624 138 16 forest forest NOUN bracis-33624 138 17 , , PUNCT bracis-33624 138 18 logistic logistic ADJ bracis-33624 138 19 regression regression NOUN bracis-33624 138 20 , , PUNCT bracis-33624 138 21 and and CCONJ bracis-33624 138 22 xgboost xgboost X bracis-33624 138 23 . . PUNCT bracis-33624 139 1 the the DET bracis-33624 139 2 random random ADJ bracis-33624 139 3 forest forest NOUN bracis-33624 139 4 model model NOUN bracis-33624 139 5 achieved achieve VERB bracis-33624 139 6 an an DET bracis-33624 139 7 accuracy accuracy NOUN bracis-33624 139 8 score score NOUN bracis-33624 139 9 of of ADP bracis-33624 139 10 57.69 57.69 NUM bracis-33624 139 11 % % NOUN bracis-33624 139 12 , , PUNCT bracis-33624 139 13 with with ADP bracis-33624 139 14 a a DET bracis-33624 139 15 perfect perfect ADJ bracis-33624 139 16 precision precision NOUN bracis-33624 139 17 of of ADP bracis-33624 139 18 100 100 NUM bracis-33624 139 19 % % NOUN bracis-33624 139 20 but but CCONJ bracis-33624 139 21 a a DET bracis-33624 139 22 very very ADV bracis-33624 139 23 low low ADJ bracis-33624 139 24 recall recall NOUN bracis-33624 139 25 of of ADP bracis-33624 139 26 5.71 5.71 NUM bracis-33624 139 27 % % NOUN bracis-33624 139 28 , , PUNCT bracis-33624 139 29 resulting result VERB bracis-33624 139 30 in in ADP bracis-33624 139 31 an an DET bracis-33624 139 32 f1 f1 ADJ bracis-33624 139 33 score score NOUN bracis-33624 139 34 of of ADP bracis-33624 139 35 10.81 10.81 NUM bracis-33624 139 36 % % NOUN bracis-33624 139 37 . . PUNCT bracis-33624 140 1 this this PRON bracis-33624 140 2 indicates indicate VERB bracis-33624 140 3 a a DET bracis-33624 140 4 strong strong ADJ bracis-33624 140 5 bias bias NOUN bracis-33624 140 6 toward toward ADP bracis-33624 140 7 predicting predict VERB bracis-33624 140 8 the the DET bracis-33624 140 9 negative negative ADJ bracis-33624 140 10 class class NOUN bracis-33624 140 11 , , PUNCT bracis-33624 140 12 limiting limit VERB bracis-33624 140 13 its its PRON bracis-33624 140 14 ability ability NOUN bracis-33624 140 15 to to PART bracis-33624 140 16 accurately accurately ADV bracis-33624 140 17 identify identify VERB bracis-33624 140 18 the the DET bracis-33624 140 19 positive positive ADJ bracis-33624 140 20 class class NOUN bracis-33624 140 21 . . PUNCT bracis-33624 141 1 logistic logistic ADJ bracis-33624 141 2 regression regression NOUN bracis-33624 141 3 also also ADV bracis-33624 141 4 achieved achieve VERB bracis-33624 141 5 an an DET bracis-33624 141 6 accuracy accuracy NOUN bracis-33624 141 7 of of ADP bracis-33624 141 8 57.69 57.69 NUM bracis-33624 141 9 % % NOUN bracis-33624 141 10 , , PUNCT bracis-33624 141 11 with with ADP bracis-33624 141 12 a a DET bracis-33624 141 13 precision precision NOUN bracis-33624 141 14 of of ADP bracis-33624 141 15 60 60 NUM bracis-33624 141 16 % % NOUN bracis-33624 141 17 and and CCONJ bracis-33624 141 18 a a DET bracis-33624 141 19 recall recall NOUN bracis-33624 141 20 of of ADP bracis-33624 141 21 17.14 17.14 NUM bracis-33624 141 22 % % NOUN bracis-33624 141 23 , , PUNCT bracis-33624 141 24 leading lead VERB bracis-33624 141 25 to to ADP bracis-33624 141 26 an an DET bracis-33624 141 27 f1 f1 ADJ bracis-33624 141 28 score score NOUN bracis-33624 141 29 of of ADP bracis-33624 141 30 26.67 26.67 NUM bracis-33624 141 31 % % NOUN bracis-33624 141 32 . . PUNCT bracis-33624 142 1 compared compare VERB bracis-33624 142 2 to to ADP bracis-33624 142 3 random random ADJ bracis-33624 142 4 forest forest NOUN bracis-33624 142 5 , , PUNCT bracis-33624 142 6 logistic logistic ADJ bracis-33624 142 7 regression regression NOUN bracis-33624 142 8 exhibited exhibit VERB bracis-33624 142 9 a a DET bracis-33624 142 10 slightly slightly ADV bracis-33624 142 11 better well ADJ bracis-33624 142 12 balance balance NOUN bracis-33624 142 13 between between ADP bracis-33624 142 14 precision precision NOUN bracis-33624 142 15 and and CCONJ bracis-33624 142 16 recall recall NOUN bracis-33624 142 17 . . PUNCT bracis-33624 143 1 lastly lastly ADV bracis-33624 143 2 , , PUNCT bracis-33624 143 3 the the DET bracis-33624 143 4 xgboost xgboost PROPN bracis-33624 143 5 model model PROPN bracis-33624 143 6 recorded record VERB bracis-33624 143 7 an an DET bracis-33624 143 8 accuracy accuracy NOUN bracis-33624 143 9 of of ADP bracis-33624 143 10 53.85 53.85 NUM bracis-33624 143 11 % % NOUN bracis-33624 143 12 , , PUNCT bracis-33624 143 13 with with ADP bracis-33624 143 14 a a DET bracis-33624 143 15 precision precision NOUN bracis-33624 143 16 of of ADP bracis-33624 143 17 47.62 47.62 NUM bracis-33624 143 18 % % NOUN bracis-33624 143 19 , , PUNCT bracis-33624 143 20 recall recall NOUN bracis-33624 143 21 of of ADP bracis-33624 143 22 28.57 28.57 NUM bracis-33624 143 23 % % NOUN bracis-33624 143 24 , , PUNCT bracis-33624 143 25 and and CCONJ bracis-33624 143 26 an an DET bracis-33624 143 27 f1 f1 ADJ bracis-33624 143 28 score score NOUN bracis-33624 143 29 of of ADP bracis-33624 143 30 35.71 35.71 NUM bracis-33624 143 31 % % NOUN bracis-33624 143 32 . . PUNCT bracis-33624 144 1 although although SCONJ bracis-33624 144 2 xgboost xgboost PROPN bracis-33624 144 3 had have VERB bracis-33624 144 4 a a DET bracis-33624 144 5 lower low ADJ bracis-33624 144 6 overall overall ADJ bracis-33624 144 7 accuracy accuracy NOUN bracis-33624 144 8 , , PUNCT bracis-33624 144 9 it it PRON bracis-33624 144 10 showed show VERB bracis-33624 144 11 a a DET bracis-33624 144 12 more more ADV bracis-33624 144 13 balanced balanced ADJ bracis-33624 144 14 performance performance NOUN bracis-33624 144 15 across across ADP bracis-33624 144 16 all all DET bracis-33624 144 17 metrics metric NOUN bracis-33624 144 18 ( ( PUNCT bracis-33624 144 19 table table NOUN bracis-33624 144 20 2 2 NUM bracis-33624 144 21 ) ) PUNCT bracis-33624 144 22 . . PUNCT bracis-33624 145 1 table table NOUN bracis-33624 145 2 2 2 NUM bracis-33624 145 3 . . PUNCT bracis-33624 145 4 ad ad NOUN bracis-33624 145 5 prediction prediction NOUN bracis-33624 145 6 resultsfull resultsfull NOUN bracis-33624 145 7 size size NOUN bracis-33624 145 8 table table NOUN bracis-33624 145 9 table table NOUN bracis-33624 145 10 3 3 NUM bracis-33624 145 11 . . PUNCT bracis-33624 145 12 selected select VERB bracis-33624 145 13 hyperparameters hyperparameter NOUN bracis-33624 145 14 for for ADP bracis-33624 145 15 machine machine NOUN bracis-33624 145 16 learning learn VERB bracis-33624 145 17 modelsfull modelsfull NOUN bracis-33624 145 18 size size NOUN bracis-33624 145 19 table table NOUN bracis-33624 145 20 the the DET bracis-33624 145 21 similar similar ADJ bracis-33624 145 22 accuracy accuracy NOUN bracis-33624 145 23 observed observe VERB bracis-33624 145 24 across across ADP bracis-33624 145 25 the the DET bracis-33624 145 26 random random ADJ bracis-33624 145 27 forest forest NOUN bracis-33624 145 28 , , PUNCT bracis-33624 145 29 logistic logistic ADJ bracis-33624 145 30 regression regression NOUN bracis-33624 145 31 , , PUNCT bracis-33624 145 32 and and CCONJ bracis-33624 145 33 xgboost xgboost NUM bracis-33624 145 34 models model NOUN bracis-33624 145 35 can can AUX bracis-33624 145 36 be be AUX bracis-33624 145 37 attributed attribute VERB bracis-33624 145 38 to to ADP bracis-33624 145 39 several several ADJ bracis-33624 145 40 factors factor NOUN bracis-33624 145 41 , , PUNCT bracis-33624 145 42 including include VERB bracis-33624 145 43 the the DET bracis-33624 145 44 complexity complexity NOUN bracis-33624 145 45 of of ADP bracis-33624 145 46 alzheimer alzheimer PROPN bracis-33624 145 47 ’s ’s PART bracis-33624 145 48 disease disease NOUN bracis-33624 145 49 , , PUNCT bracis-33624 145 50 the the DET bracis-33624 145 51 quality quality NOUN bracis-33624 145 52 and and CCONJ bracis-33624 145 53 representation representation NOUN bracis-33624 145 54 of of ADP bracis-33624 145 55 the the DET bracis-33624 145 56 genetic genetic ADJ bracis-33624 145 57 data datum NOUN bracis-33624 145 58 , , PUNCT bracis-33624 145 59 model model ADJ bracis-33624 145 60 - - PUNCT bracis-33624 145 61 specific specific ADJ bracis-33624 145 62 characteristics characteristic NOUN bracis-33624 145 63 , , PUNCT bracis-33624 145 64 hyperparameter hyperparameter NOUN bracis-33624 145 65 tuning tuning NOUN bracis-33624 145 66 processes process NOUN bracis-33624 145 67 , , PUNCT bracis-33624 145 68 inherent inherent ADJ bracis-33624 145 69 data datum NOUN bracis-33624 145 70 limitations limitation NOUN bracis-33624 145 71 , , PUNCT bracis-33624 145 72 and and CCONJ bracis-33624 145 73 the the DET bracis-33624 145 74 choice choice NOUN bracis-33624 145 75 of of ADP bracis-33624 145 76 evaluation evaluation NOUN bracis-33624 145 77 metrics metric NOUN bracis-33624 145 78 . . PUNCT bracis-33624 146 1 these these DET bracis-33624 146 2 factors factor NOUN bracis-33624 146 3 collectively collectively ADV bracis-33624 146 4 influence influence VERB bracis-33624 146 5 the the DET bracis-33624 146 6 models model NOUN bracis-33624 146 7 ’ ’ PART bracis-33624 146 8 performance performance NOUN bracis-33624 146 9 , , PUNCT bracis-33624 146 10 leading lead VERB bracis-33624 146 11 to to ADP bracis-33624 146 12 convergent convergent ADJ bracis-33624 146 13 accuracy accuracy NOUN bracis-33624 146 14 levels level NOUN bracis-33624 146 15 despite despite SCONJ bracis-33624 146 16 their their PRON bracis-33624 146 17 different different ADJ bracis-33624 146 18 architectures architecture NOUN bracis-33624 146 19 and and CCONJ bracis-33624 146 20 mechanisms mechanism NOUN bracis-33624 146 21 . . PUNCT bracis-33624 147 1 4.4 4.4 NUM bracis-33624 147 2 comparative comparative ADJ bracis-33624 147 3 analysis analysis NOUN bracis-33624 147 4 of of ADP bracis-33624 147 5     SPACE bracis-33624 147 6 alzheimer alzheimer PROPN bracis-33624 147 7 ’s ’s PART bracis-33624 147 8 disease disease NOUN bracis-33624 147 9 associated associate VERB bracis-33624 147 10 snps snps PROPN bracis-33624 147 11 table table NOUN bracis-33624 147 12 4 4 NUM bracis-33624 147 13 . . NOUN bracis-33624 147 14 20 20 NUM bracis-33624 147 15 most most ADV bracis-33624 147 16 significant significant ADJ bracis-33624 147 17 snps snps NOUN bracis-33624 147 18 for for ADP bracis-33624 147 19 logistic logistic ADJ bracis-33624 147 20 regression regression NOUN bracis-33624 147 21 and and CCONJ bracis-33624 147 22 random random ADJ bracis-33624 147 23 forest.full forest.full ADJ bracis-33624 147 24 size size NOUN bracis-33624 147 25 table table NOUN bracis-33624 147 26 table table NOUN bracis-33624 147 27 5 5 NUM bracis-33624 147 28 . . NOUN bracis-33624 147 29 20 20 NUM bracis-33624 147 30 most most ADV bracis-33624 147 31 significant significant ADJ bracis-33624 147 32 snps snps NOUN bracis-33624 147 33 for for ADP bracis-33624 147 34 xgboost xgboost PROPN bracis-33624 147 35 and and CCONJ bracis-33624 147 36 gwas gwas PROPN bracis-33624 147 37 ( ( PUNCT bracis-33624 147 38 blupf90).full blupf90).full NOUN bracis-33624 147 39 size size NOUN bracis-33624 147 40 table table NOUN bracis-33624 147 41 after after ADP bracis-33624 147 42 implementing implement VERB bracis-33624 147 43 the the DET bracis-33624 147 44 machine machine NOUN bracis-33624 147 45 learning learn VERB bracis-33624 147 46 techniques technique NOUN bracis-33624 147 47 , , PUNCT bracis-33624 147 48 we we PRON bracis-33624 147 49 conducted conduct VERB bracis-33624 147 50 a a DET bracis-33624 147 51 genome genome NOUN bracis-33624 147 52 study study NOUN bracis-33624 147 53 and and CCONJ bracis-33624 147 54 benchmarked benchmarke VERB bracis-33624 147 55 the the DET bracis-33624 147 56 results result NOUN bracis-33624 147 57 of of ADP bracis-33624 147 58 each each DET bracis-33624 147 59 algorithm algorithm NOUN bracis-33624 147 60 . . PUNCT bracis-33624 148 1 this this DET bracis-33624 148 2 comparison comparison NOUN bracis-33624 148 3 was be AUX bracis-33624 148 4 performed perform VERB bracis-33624 148 5 by by ADP bracis-33624 148 6 selecting select VERB bracis-33624 148 7 the the DET bracis-33624 148 8 top top ADJ bracis-33624 148 9 20 20 NUM bracis-33624 148 10 most most ADV bracis-33624 148 11 significant significant ADJ bracis-33624 148 12 snps snps NOUN bracis-33624 148 13 for for ADP bracis-33624 148 14 each each DET bracis-33624 148 15 method method NOUN bracis-33624 148 16 , , PUNCT bracis-33624 148 17 as as SCONJ bracis-33624 148 18 presented present VERB bracis-33624 148 19 in in ADP bracis-33624 148 20 tables table NOUN bracis-33624 148 21     SPACE bracis-33624 148 22 4 4 NUM bracis-33624 148 23 and and CCONJ bracis-33624 148 24 5 5 NUM bracis-33624 148 25 , , PUNCT bracis-33624 148 26 and and CCONJ bracis-33624 148 27 analyzing analyze VERB bracis-33624 148 28 and and CCONJ bracis-33624 148 29 comparing compare VERB bracis-33624 148 30 the the DET bracis-33624 148 31 identified identify VERB bracis-33624 148 32 genes gene NOUN bracis-33624 148 33 with with ADP bracis-33624 148 34 those those PRON bracis-33624 148 35 reported report VERB bracis-33624 148 36 in in ADP bracis-33624 148 37 the the DET bracis-33624 148 38 literature literature NOUN bracis-33624 148 39 . . PUNCT bracis-33624 149 1 instances instance NOUN bracis-33624 149 2 of of ADP bracis-33624 149 3 absent absent ADJ bracis-33624 149 4 genes gene NOUN bracis-33624 149 5 in in ADP bracis-33624 149 6 the the DET bracis-33624 149 7 tables table NOUN bracis-33624 149 8     SPACE bracis-33624 149 9 4 4 NUM bracis-33624 149 10 and and CCONJ bracis-33624 149 11 5 5 NUM bracis-33624 149 12 indicate indicate VERB bracis-33624 149 13 ’ ' PUNCT bracis-33624 149 14 no no DET bracis-33624 149 15 gene gene NOUN bracis-33624 149 16 association association NOUN bracis-33624 149 17 ’ ' PUNCT bracis-33624 149 18 . . PUNCT bracis-33624 150 1 this this DET bracis-33624 150 2 phenomenon phenomenon NOUN bracis-33624 150 3 can can AUX bracis-33624 150 4 be be AUX bracis-33624 150 5 attributed attribute VERB bracis-33624 150 6 to to ADP bracis-33624 150 7 the the DET bracis-33624 150 8 occurrence occurrence NOUN bracis-33624 150 9 of of ADP bracis-33624 150 10 snps snps PROPN bracis-33624 150 11 in in ADP bracis-33624 150 12 non non ADJ bracis-33624 150 13 - - ADJ bracis-33624 150 14 coding coding ADJ bracis-33624 150 15 regions region NOUN bracis-33624 150 16 of of ADP bracis-33624 150 17 the the DET bracis-33624 150 18 genome genome NOUN bracis-33624 150 19 . . PUNCT bracis-33624 151 1 while while SCONJ bracis-33624 151 2 not not PART bracis-33624 151 3 directly directly ADV bracis-33624 151 4 associated associate VERB bracis-33624 151 5 with with ADP bracis-33624 151 6 known know VERB bracis-33624 151 7 genes gene NOUN bracis-33624 151 8 , , PUNCT bracis-33624 151 9 such such ADJ bracis-33624 151 10 regions region NOUN bracis-33624 151 11 can can AUX bracis-33624 151 12 still still ADV bracis-33624 151 13 play play VERB bracis-33624 151 14 a a DET bracis-33624 151 15 crucial crucial ADJ bracis-33624 151 16 role role NOUN bracis-33624 151 17 in in ADP bracis-33624 151 18 gene gene NOUN bracis-33624 151 19 regulation regulation NOUN bracis-33624 151 20 or or CCONJ bracis-33624 151 21 the the DET bracis-33624 151 22 production production NOUN bracis-33624 151 23 of of ADP bracis-33624 151 24 non non ADJ bracis-33624 151 25 - - ADJ bracis-33624 151 26 coding coding ADJ bracis-33624 151 27 rnas rna NOUN bracis-33624 151 28 , , PUNCT bracis-33624 151 29 thereby thereby ADV bracis-33624 151 30 indirectly indirectly ADV bracis-33624 151 31 influencing influence VERB bracis-33624 151 32 gene gene NOUN bracis-33624 151 33 function function NOUN bracis-33624 151 34 [ [ X bracis-33624 151 35 14 14 NUM bracis-33624 151 36 ] ] PUNCT bracis-33624 151 37 . . PUNCT bracis-33624 152 1 through through ADP bracis-33624 152 2 this this DET bracis-33624 152 3 analysis analysis NOUN bracis-33624 152 4 , , PUNCT bracis-33624 152 5 we we PRON bracis-33624 152 6 identified identify VERB bracis-33624 152 7 that that SCONJ bracis-33624 152 8 the the DET bracis-33624 152 9 models model NOUN bracis-33624 152 10 successfully successfully ADV bracis-33624 152 11 detected detect VERB bracis-33624 152 12 snps snps PROPN bracis-33624 152 13 previously previously ADV bracis-33624 152 14 associated associate VERB bracis-33624 152 15 with with ADP bracis-33624 152 16 alzheimer alzheimer PROPN bracis-33624 152 17 ’s ’s PART bracis-33624 152 18 disease disease NOUN bracis-33624 152 19 and and CCONJ bracis-33624 152 20 other other ADJ bracis-33624 152 21 neurological neurological ADJ bracis-33624 152 22 functions function NOUN bracis-33624 152 23 . . PUNCT bracis-33624 153 1 this this DET bracis-33624 153 2 finding finding NOUN bracis-33624 153 3 underscores underscore VERB bracis-33624 153 4 the the DET bracis-33624 153 5 potential potential NOUN bracis-33624 153 6 of of ADP bracis-33624 153 7 ml ml NOUN bracis-33624 153 8 models model NOUN bracis-33624 153 9 for for ADP bracis-33624 153 10 identifying identify VERB bracis-33624 153 11 genetic genetic ADJ bracis-33624 153 12 markers marker NOUN bracis-33624 153 13 linked link VERB bracis-33624 153 14 to to ADP bracis-33624 153 15 complex complex ADJ bracis-33624 153 16 diseases disease NOUN bracis-33624 153 17 such such ADJ bracis-33624 153 18 as as ADP bracis-33624 153 19 alzheimer alzheimer PROPN bracis-33624 153 20 ’s ’s PART bracis-33624 153 21 disease disease NOUN bracis-33624 153 22 . . PUNCT bracis-33624 154 1 logistic logistic ADJ bracis-33624 154 2 regression regression NOUN bracis-33624 154 3 identified identify VERB bracis-33624 154 4 specific specific ADJ bracis-33624 154 5 snps snps PROPN bracis-33624 154 6 with with ADP bracis-33624 154 7 positive positive ADJ bracis-33624 154 8 and and CCONJ bracis-33624 154 9 negative negative ADJ bracis-33624 154 10 coefficients coefficient NOUN bracis-33624 154 11 , , PUNCT bracis-33624 154 12 indicating indicate VERB bracis-33624 154 13 the the DET bracis-33624 154 14 presence presence NOUN bracis-33624 154 15 of of ADP bracis-33624 154 16 both both CCONJ bracis-33624 154 17 protective protective ADJ bracis-33624 154 18 and and CCONJ bracis-33624 154 19 risk risk NOUN bracis-33624 154 20 alleles allele NOUN bracis-33624 154 21 for for ADP bracis-33624 154 22 ad ad NOUN bracis-33624 154 23 . . PUNCT bracis-33624 155 1 on on ADP bracis-33624 155 2 the the DET bracis-33624 155 3 other other ADJ bracis-33624 155 4 hand hand NOUN bracis-33624 155 5 , , PUNCT bracis-33624 155 6 the the DET bracis-33624 155 7 random random ADJ bracis-33624 155 8 forest forest NOUN bracis-33624 155 9 model model NOUN bracis-33624 155 10 assigned assign VERB bracis-33624 155 11 greater great ADJ bracis-33624 155 12 significance significance NOUN bracis-33624 155 13 to to ADP bracis-33624 155 14 a a DET bracis-33624 155 15 different different ADJ bracis-33624 155 16 set set NOUN bracis-33624 155 17 of of ADP bracis-33624 155 18 snps snps PROPN bracis-33624 155 19 , , PUNCT bracis-33624 155 20 with with ADP bracis-33624 155 21 feature feature NOUN bracis-33624 155 22 importances importance NOUN bracis-33624 155 23 varying vary VERB bracis-33624 155 24 in in ADP bracis-33624 155 25 the the DET bracis-33624 155 26 order order NOUN bracis-33624 155 27 of of ADP bracis-33624 155 28 \(10^{-4}\ \(10^{-4}\ NOUN bracis-33624 155 29 ) ) PUNCT bracis-33624 155 30 . . PUNCT bracis-33624 156 1 the the DET bracis-33624 156 2 xgboost xgboost PROPN bracis-33624 156 3 model model PROPN bracis-33624 156 4 identified identify VERB bracis-33624 156 5 a a DET bracis-33624 156 6 collection collection NOUN bracis-33624 156 7 of of ADP bracis-33624 156 8 snps snps PROPN bracis-33624 156 9 , , PUNCT bracis-33624 156 10 with with ADP bracis-33624 156 11 importances importance NOUN bracis-33624 156 12 ranging range VERB bracis-33624 156 13 around around ADP bracis-33624 156 14 \(10^{-2}\ \(10^{-2}\ NOUN bracis-33624 156 15 ) ) PUNCT bracis-33624 156 16 , , PUNCT bracis-33624 156 17 emphasizing emphasize VERB bracis-33624 156 18 the the DET bracis-33624 156 19 relevance relevance NOUN bracis-33624 156 20 of of ADP bracis-33624 156 21 each each DET bracis-33624 156 22 snp snp NOUN bracis-33624 156 23 more more ADV bracis-33624 156 24 equally equally ADV bracis-33624 156 25 . . PUNCT bracis-33624 157 1 finally finally ADV bracis-33624 157 2 , , PUNCT bracis-33624 157 3 the the DET bracis-33624 157 4 gwas gwas NOUN bracis-33624 157 5 analysis analysis NOUN bracis-33624 157 6 using use VERB bracis-33624 157 7 blupf90 blupf90 NOUN bracis-33624 157 8 provided provide VERB bracis-33624 157 9 a a DET bracis-33624 157 10 separate separate ADJ bracis-33624 157 11 set set NOUN bracis-33624 157 12 of of ADP bracis-33624 157 13 snps snps PROPN bracis-33624 157 14 based base VERB bracis-33624 157 15 on on ADP bracis-33624 157 16 highly highly ADV bracis-33624 157 17 p_value p_value NOUN bracis-33624 157 18 , , PUNCT bracis-33624 157 19 some some PRON bracis-33624 157 20 of of ADP bracis-33624 157 21 which which PRON bracis-33624 157 22 were be AUX bracis-33624 157 23 not not PART bracis-33624 157 24 detected detect VERB bracis-33624 157 25 by by ADP bracis-33624 157 26 the the DET bracis-33624 157 27 other other ADJ bracis-33624 157 28 models model NOUN bracis-33624 157 29 . . PUNCT bracis-33624 158 1 based base VERB bracis-33624 158 2 on on ADP bracis-33624 158 3 the the DET bracis-33624 158 4 xgboost xgboost PROPN bracis-33624 158 5 model model PROPN bracis-33624 158 6 analysis analysis NOUN bracis-33624 158 7 , , PUNCT bracis-33624 158 8 several several ADJ bracis-33624 158 9 genes gene NOUN bracis-33624 158 10 and and CCONJ bracis-33624 158 11 single single ADJ bracis-33624 158 12 nucleotide nucleotide ADJ bracis-33624 158 13 polymorphisms polymorphism NOUN bracis-33624 158 14 ( ( PUNCT bracis-33624 158 15 snps snps PROPN bracis-33624 158 16 ) ) PUNCT bracis-33624 158 17 were be AUX bracis-33624 158 18 identified identify VERB bracis-33624 158 19 in in ADP bracis-33624 158 20 relation relation NOUN bracis-33624 158 21 to to ADP bracis-33624 158 22 alzheimer alzheimer PROPN bracis-33624 158 23 ’s ’s PART bracis-33624 158 24 disease disease NOUN bracis-33624 158 25 ( ( PUNCT bracis-33624 158 26 ad ad NOUN bracis-33624 158 27 ) ) PUNCT bracis-33624 158 28 . . PUNCT bracis-33624 159 1 the the DET bracis-33624 159 2 galnt13 galnt13 ADJ bracis-33624 159 3 gene gene NOUN bracis-33624 159 4 , , PUNCT bracis-33624 159 5 crucial crucial ADJ bracis-33624 159 6 for for ADP bracis-33624 159 7 neural neural ADJ bracis-33624 159 8 development development NOUN bracis-33624 159 9 , , PUNCT bracis-33624 159 10 is be AUX bracis-33624 159 11 strongly strongly ADV bracis-33624 159 12 associated associate VERB bracis-33624 159 13 with with ADP bracis-33624 159 14 ad ad NOUN bracis-33624 159 15 [ [ X bracis-33624 159 16 9 9 NUM bracis-33624 159 17 , , PUNCT bracis-33624 159 18 19 19 NUM bracis-33624 159 19 ] ] PUNCT bracis-33624 159 20 . . PUNCT bracis-33624 160 1 the the DET bracis-33624 160 2 rs6507641 rs6507641 PROPN bracis-33624 160 3 snp snp VERB bracis-33624 160 4 in in ADP bracis-33624 160 5 the the DET bracis-33624 160 6 slc14a1 slc14a1 PROPN bracis-33624 160 7 gene gene NOUN bracis-33624 160 8 , , PUNCT bracis-33624 160 9 involved involve VERB bracis-33624 160 10 in in ADP bracis-33624 160 11 urea urea NOUN bracis-33624 160 12 transport transport NOUN bracis-33624 160 13 , , PUNCT bracis-33624 160 14 has have AUX bracis-33624 160 15 also also ADV bracis-33624 160 16 been be AUX bracis-33624 160 17 linked link VERB bracis-33624 160 18 to to ADP bracis-33624 160 19 ad ad NOUN bracis-33624 160 20 [ [ X bracis-33624 160 21 31 31 NUM bracis-33624 160 22 ] ] PUNCT bracis-33624 160 23 . . PUNCT bracis-33624 161 1 the the DET bracis-33624 161 2 rs6037744 rs6037744 PROPN bracis-33624 161 3 snp snp NOUN bracis-33624 161 4 , , PUNCT bracis-33624 161 5 although although SCONJ bracis-33624 161 6 not not PART bracis-33624 161 7 directly directly ADV bracis-33624 161 8 associated associate VERB bracis-33624 161 9 with with ADP bracis-33624 161 10 a a DET bracis-33624 161 11 specific specific ADJ bracis-33624 161 12 gene gene NOUN bracis-33624 161 13 , , PUNCT bracis-33624 161 14 is be AUX bracis-33624 161 15 linked link VERB bracis-33624 161 16 to to ADP bracis-33624 161 17 increased increase VERB bracis-33624 161 18 susceptibility susceptibility NOUN bracis-33624 161 19 to to ADP bracis-33624 161 20 optic optic VERB bracis-33624 161 21 nerve nerve NOUN bracis-33624 161 22 degeneration degeneration NOUN bracis-33624 161 23 in in ADP bracis-33624 161 24 glaucoma glaucoma NOUN bracis-33624 161 25 . . PUNCT bracis-33624 162 1 both both DET bracis-33624 162 2 conditions condition NOUN bracis-33624 162 3 involve involve VERB bracis-33624 162 4 nerve nerve NOUN bracis-33624 162 5 cell cell NOUN bracis-33624 162 6 death death NOUN bracis-33624 162 7 and and CCONJ bracis-33624 162 8 abnormal abnormal ADJ bracis-33624 162 9 proteins protein NOUN bracis-33624 162 10 , , PUNCT bracis-33624 162 11 suggesting suggest VERB bracis-33624 162 12 a a DET bracis-33624 162 13 broader broad ADJ bracis-33624 162 14 neurodegenerative neurodegenerative ADJ bracis-33624 162 15 process process NOUN bracis-33624 162 16 [ [ X bracis-33624 162 17 37 37 NUM bracis-33624 162 18 ] ] PUNCT bracis-33624 162 19 . . PUNCT bracis-33624 163 1 studies study NOUN bracis-33624 163 2 have have AUX bracis-33624 163 3 also also ADV bracis-33624 163 4 found find VERB bracis-33624 163 5 that that SCONJ bracis-33624 163 6 glaucoma glaucoma NOUN bracis-33624 163 7 patients patient NOUN bracis-33624 163 8 are be AUX bracis-33624 163 9 four four NUM bracis-33624 163 10 times time NOUN bracis-33624 163 11 more more ADV bracis-33624 163 12 likely likely ADJ bracis-33624 163 13 to to PART bracis-33624 163 14 develop develop VERB bracis-33624 163 15 dementia dementia NOUN bracis-33624 163 16 , , PUNCT bracis-33624 163 17 highlighting highlight VERB bracis-33624 163 18 a a DET bracis-33624 163 19 potential potential ADJ bracis-33624 163 20 connection connection NOUN bracis-33624 163 21 between between ADP bracis-33624 163 22 glaucoma glaucoma NOUN bracis-33624 163 23 and and CCONJ bracis-33624 163 24 ad ad NOUN bracis-33624 164 1 [ [ X bracis-33624 164 2 28 28 NUM bracis-33624 164 3 ] ] PUNCT bracis-33624 164 4 . . PUNCT bracis-33624 165 1 lastly lastly ADV bracis-33624 165 2 , , PUNCT bracis-33624 165 3 the the DET bracis-33624 165 4 rs10933234 rs10933234 ADJ bracis-33624 165 5 snp snp NOUN bracis-33624 165 6 in in ADP bracis-33624 165 7 the the DET bracis-33624 165 8 sphkap sphkap PROPN bracis-33624 165 9 gene gene NOUN bracis-33624 165 10 has have AUX bracis-33624 165 11 been be AUX bracis-33624 165 12 suggested suggest VERB bracis-33624 165 13 to to PART bracis-33624 165 14 be be AUX bracis-33624 165 15 involved involve VERB bracis-33624 165 16 in in ADP bracis-33624 165 17 the the DET bracis-33624 165 18 ad ad NOUN bracis-33624 165 19 process process NOUN bracis-33624 165 20 [ [ X bracis-33624 165 21 38 38 NUM bracis-33624 165 22 ] ] PUNCT bracis-33624 165 23 . . PUNCT bracis-33624 166 1 for for ADP bracis-33624 166 2 the the DET bracis-33624 166 3 logistic logistic ADJ bracis-33624 166 4 regression regression NOUN bracis-33624 166 5 model model NOUN bracis-33624 166 6 , , PUNCT bracis-33624 166 7 it it PRON bracis-33624 166 8 was be AUX bracis-33624 166 9 found find VERB bracis-33624 166 10 that that SCONJ bracis-33624 166 11 the the DET bracis-33624 166 12 fgf13 fgf13 PROPN bracis-33624 166 13 gene gene NOUN bracis-33624 166 14 is be AUX bracis-33624 166 15 related relate VERB bracis-33624 166 16 to to ADP bracis-33624 166 17 ameliorating ameliorate VERB bracis-33624 166 18 amyloid-\(\beta amyloid-\(\beta ADJ bracis-33624 166 19 \)-induced \)-induced ADJ bracis-33624 166 20 neuronal neuronal ADJ bracis-33624 166 21 damage damage NOUN bracis-33624 166 22 , , PUNCT bracis-33624 166 23 acting act VERB bracis-33624 166 24 as as ADP bracis-33624 166 25 a a DET bracis-33624 166 26 protective protective ADJ bracis-33624 166 27 factor factor NOUN bracis-33624 166 28 [ [ X bracis-33624 166 29 24 24 NUM bracis-33624 166 30 ] ] PUNCT bracis-33624 166 31 , , PUNCT bracis-33624 166 32 as as SCONJ bracis-33624 166 33 shown show VERB bracis-33624 166 34 by by ADP bracis-33624 166 35 the the DET bracis-33624 166 36 negative negative ADJ bracis-33624 166 37 coefficient coefficient NOUN bracis-33624 166 38 in in ADP bracis-33624 166 39 the the DET bracis-33624 166 40 logistic logistic ADJ bracis-33624 166 41 regression regression NOUN bracis-33624 166 42 . . PUNCT bracis-33624 167 1 the the DET bracis-33624 167 2 arhgap36 arhgap36 NOUN bracis-33624 167 3 gene gene NOUN bracis-33624 167 4 has have AUX bracis-33624 167 5 been be AUX bracis-33624 167 6 associated associate VERB bracis-33624 167 7 with with ADP bracis-33624 167 8 excitatory excitatory NOUN bracis-33624 167 9 - - PUNCT bracis-33624 167 10 inhibitory inhibitory ADJ bracis-33624 167 11 neuronal neuronal ADJ bracis-33624 167 12 analyses analysis NOUN bracis-33624 167 13 within within ADP bracis-33624 167 14 the the DET bracis-33624 167 15 dg dg PROPN bracis-33624 167 16 granule granule NOUN bracis-33624 167 17 cell cell NOUN bracis-33624 167 18 layer layer NOUN bracis-33624 167 19 , , PUNCT bracis-33624 167 20 also also ADV bracis-33624 167 21 serving serve VERB bracis-33624 167 22 as as ADP bracis-33624 167 23 a a DET bracis-33624 167 24 protector protector NOUN bracis-33624 167 25 [ [ X bracis-33624 167 26 25 25 NUM bracis-33624 167 27 ] ] PUNCT bracis-33624 167 28 . . PUNCT bracis-33624 168 1 the the DET bracis-33624 168 2 abca4 abca4 PROPN bracis-33624 168 3 gene gene NOUN bracis-33624 168 4 , , PUNCT bracis-33624 168 5 linked link VERB bracis-33624 168 6 to to ADP bracis-33624 168 7 rs497511 rs497511 NOUN bracis-33624 168 8 , , PUNCT bracis-33624 168 9 is be AUX bracis-33624 168 10 highly highly ADV bracis-33624 168 11 associated associate VERB bracis-33624 168 12 with with ADP bracis-33624 168 13 ad ad NOUN bracis-33624 168 14 and and CCONJ bracis-33624 168 15 frontotemporal frontotemporal ADJ bracis-33624 168 16 lobar lobar ADJ bracis-33624 168 17 degeneration degeneration NOUN bracis-33624 168 18 with with ADP bracis-33624 168 19 tdp-43 tdp-43 NOUN bracis-33624 168 20 protein protein NOUN bracis-33624 168 21 inclusions inclusion NOUN bracis-33624 168 22 [ [ X bracis-33624 168 23 21 21 NUM bracis-33624 168 24 ] ] PUNCT bracis-33624 168 25 . . PUNCT bracis-33624 169 1 the the DET bracis-33624 169 2 sytl2 sytl2 NOUN bracis-33624 169 3 gene gene NOUN bracis-33624 169 4 was be AUX bracis-33624 169 5 found find VERB bracis-33624 169 6 among among ADP bracis-33624 169 7 the the DET bracis-33624 169 8 top top ADJ bracis-33624 169 9 genes gene NOUN bracis-33624 169 10 with with ADP bracis-33624 169 11 significant significant ADJ bracis-33624 169 12 alzheimer alzheimer PROPN bracis-33624 169 13 ’s ’s PART bracis-33624 169 14 loci locus NOUN bracis-33624 169 15 in in ADP bracis-33624 169 16 the the DET bracis-33624 169 17 study study NOUN bracis-33624 169 18 conducted conduct VERB bracis-33624 169 19 by by ADP bracis-33624 169 20 oxford oxford PROPN bracis-33624 169 21 [ [ X bracis-33624 169 22 11 11 NUM bracis-33624 169 23 ] ] PUNCT bracis-33624 169 24 . . PUNCT bracis-33624 170 1 the the DET bracis-33624 170 2 expression expression NOUN bracis-33624 170 3 of of ADP bracis-33624 170 4 frmpd4 frmpd4 NOUN bracis-33624 170 5 , , PUNCT bracis-33624 170 6 indicated indicate VERB bracis-33624 170 7 by by ADP bracis-33624 170 8 rs7880350 rs7880350 PROPN bracis-33624 170 9 , , PUNCT bracis-33624 170 10 is be AUX bracis-33624 170 11 significantly significantly ADV bracis-33624 170 12 altered alter VERB bracis-33624 170 13 in in ADP bracis-33624 170 14 the the DET bracis-33624 170 15 ad ad NOUN bracis-33624 170 16 hippocampus hippocampus NOUN bracis-33624 170 17 [ [ X bracis-33624 170 18 8 8 NUM bracis-33624 170 19 ] ] PUNCT bracis-33624 170 20 . . PUNCT bracis-33624 171 1 based base VERB bracis-33624 171 2 on on ADP bracis-33624 171 3 the the DET bracis-33624 171 4 random random ADJ bracis-33624 171 5 forest forest NOUN bracis-33624 171 6 model model NOUN bracis-33624 171 7 , , PUNCT bracis-33624 171 8 the the DET bracis-33624 171 9 cd207 cd207 PROPN bracis-33624 171 10 gene gene NOUN bracis-33624 171 11 was be AUX bracis-33624 171 12 identified identify VERB bracis-33624 171 13 as as ADP bracis-33624 171 14 one one NUM bracis-33624 171 15 of of ADP bracis-33624 171 16 the the DET bracis-33624 171 17 top top ADJ bracis-33624 171 18 10 10 NUM bracis-33624 171 19 most most ADV bracis-33624 171 20 differentially differentially ADV bracis-33624 171 21 expressed express VERB bracis-33624 171 22 genes gene NOUN bracis-33624 171 23 in in ADP bracis-33624 171 24 ad ad NOUN bracis-33624 171 25 , , PUNCT bracis-33624 171 26 according accord VERB bracis-33624 171 27 to to ADP bracis-33624 171 28 a a DET bracis-33624 171 29 study study NOUN bracis-33624 171 30 [ [ X bracis-33624 171 31 15 15 NUM bracis-33624 171 32 ] ] PUNCT bracis-33624 171 33 . . PUNCT bracis-33624 172 1 the the DET bracis-33624 172 2 or51b6 or51b6 PROPN bracis-33624 172 3 gene gene NOUN bracis-33624 172 4 , , PUNCT bracis-33624 172 5 an an DET bracis-33624 172 6 olfactory olfactory ADJ bracis-33624 172 7 receptor receptor NOUN bracis-33624 172 8 , , PUNCT bracis-33624 172 9 shows show VERB bracis-33624 172 10 the the DET bracis-33624 172 11 highest high ADJ bracis-33624 172 12 number number NOUN bracis-33624 172 13 of of ADP bracis-33624 172 14 associated associated ADJ bracis-33624 172 15 variants variant NOUN bracis-33624 172 16 and and CCONJ bracis-33624 172 17 is be AUX bracis-33624 172 18 expressed express VERB bracis-33624 172 19 in in ADP bracis-33624 172 20 temporal temporal ADJ bracis-33624 172 21 cortex cortex NOUN bracis-33624 172 22 neurons neuron NOUN bracis-33624 172 23 [ [ X bracis-33624 172 24 32 32 NUM bracis-33624 172 25 ] ] PUNCT bracis-33624 172 26 . . PUNCT bracis-33624 173 1 the the DET bracis-33624 173 2 sox13 sox13 NOUN bracis-33624 173 3 and and CCONJ bracis-33624 173 4 plxnd1 plxnd1 NOUN bracis-33624 173 5 genes gene NOUN bracis-33624 173 6 were be AUX bracis-33624 173 7 associated associate VERB bracis-33624 173 8 with with ADP bracis-33624 173 9 ad ad NOUN bracis-33624 173 10 in in ADP bracis-33624 173 11 various various ADJ bracis-33624 173 12 studies study NOUN bracis-33624 173 13 [ [ X bracis-33624 173 14 6 6 NUM bracis-33624 173 15 , , PUNCT bracis-33624 173 16 27 27 NUM bracis-33624 173 17 ] ] PUNCT bracis-33624 173 18 . . PUNCT bracis-33624 174 1 the the DET bracis-33624 174 2 pde8b pde8b PROPN bracis-33624 174 3 gene gene NOUN bracis-33624 174 4 shows show NOUN bracis-33624 174 5 altered alter VERB bracis-33624 174 6 mrna mrna PROPN bracis-33624 174 7 expression expression NOUN bracis-33624 174 8 in in ADP bracis-33624 174 9 ad ad NOUN bracis-33624 174 10 brains brain NOUN bracis-33624 174 11 at at ADP bracis-33624 174 12 different different ADJ bracis-33624 174 13 disease disease NOUN bracis-33624 174 14 stages stage VERB bracis-33624 174 15     SPACE bracis-33624 175 1 [ [ X bracis-33624 175 2 30 30 NUM bracis-33624 175 3 ] ] PUNCT bracis-33624 175 4 . . PUNCT bracis-33624 176 1 blup blup PROPN bracis-33624 176 2 discoveries discovery NOUN bracis-33624 176 3 identified identify VERB bracis-33624 176 4 several several ADJ bracis-33624 176 5 genes gene NOUN bracis-33624 176 6 previously previously ADV bracis-33624 176 7 associated associate VERB bracis-33624 176 8 with with ADP bracis-33624 176 9 ad ad NOUN bracis-33624 176 10 in in ADP bracis-33624 176 11 the the DET bracis-33624 176 12 literature literature NOUN bracis-33624 176 13 , , PUNCT bracis-33624 176 14 including include VERB bracis-33624 176 15 cntn6 cntn6 PROPN bracis-33624 176 16 , , PUNCT bracis-33624 176 17 klf12 klf12 NOUN bracis-33624 176 18 , , PUNCT bracis-33624 176 19 rps6ka2 rps6ka2 PROPN bracis-33624 176 20 , , PUNCT bracis-33624 176 21 mln mln NOUN bracis-33624 176 22 , , PUNCT bracis-33624 176 23 fancc fancc NOUN bracis-33624 176 24 , , PUNCT bracis-33624 176 25 abca8 abca8 NOUN bracis-33624 176 26 and and CCONJ bracis-33624 176 27 adcy9 adcy9 NOUN bracis-33624 176 28 . . PUNCT bracis-33624 177 1 these these DET bracis-33624 177 2 genes gene NOUN bracis-33624 177 3 are be AUX bracis-33624 177 4 essential essential ADJ bracis-33624 177 5 in in ADP bracis-33624 177 6 regulating regulate VERB bracis-33624 177 7 synaptic synaptic ADJ bracis-33624 177 8 plasticity plasticity NOUN bracis-33624 177 9 , , PUNCT bracis-33624 177 10 biomarkers biomarker NOUN bracis-33624 177 11 for for ADP bracis-33624 177 12 ad ad NOUN bracis-33624 177 13 , , PUNCT bracis-33624 177 14 inflammatory inflammatory ADJ bracis-33624 177 15 responses response NOUN bracis-33624 177 16 , , PUNCT bracis-33624 177 17 neuritogenesis neuritogenesis ADV bracis-33624 177 18 , , PUNCT bracis-33624 177 19 and and CCONJ bracis-33624 177 20 biochemical biochemical ADJ bracis-33624 177 21 pathways pathway NOUN bracis-33624 177 22 of of ADP bracis-33624 177 23 ad ad NOUN bracis-33624 177 24 . . PUNCT bracis-33624 178 1 these these DET bracis-33624 178 2 discoveries discovery NOUN bracis-33624 178 3 offer offer VERB bracis-33624 178 4 valuable valuable ADJ bracis-33624 178 5 insights insight NOUN bracis-33624 178 6 into into ADP bracis-33624 178 7 the the DET bracis-33624 178 8 molecular molecular ADJ bracis-33624 178 9 mechanisms mechanism NOUN bracis-33624 178 10 underlying underlie VERB bracis-33624 178 11 ad ad NOUN bracis-33624 178 12 and and CCONJ bracis-33624 178 13 could could AUX bracis-33624 178 14 lead lead VERB bracis-33624 178 15 to to ADP bracis-33624 178 16 the the DET bracis-33624 178 17 development development NOUN bracis-33624 178 18 of of ADP bracis-33624 178 19 innovative innovative ADJ bracis-33624 178 20 diagnostic diagnostic ADJ bracis-33624 178 21 tools tool NOUN bracis-33624 178 22 and and CCONJ bracis-33624 178 23 treatments treatment NOUN bracis-33624 178 24 for for ADP bracis-33624 178 25 this this DET bracis-33624 178 26 debilitating debilitate VERB bracis-33624 178 27 disease disease NOUN bracis-33624 178 28 [ [ X bracis-33624 178 29 4 4 NUM bracis-33624 178 30 , , PUNCT bracis-33624 178 31 7 7 NUM bracis-33624 178 32 , , PUNCT bracis-33624 178 33 13 13 NUM bracis-33624 178 34 , , PUNCT bracis-33624 178 35 23 23 NUM bracis-33624 178 36 ] ] PUNCT bracis-33624 178 37 . . PUNCT bracis-33624 179 1 comparing compare VERB bracis-33624 179 2 the the DET bracis-33624 179 3 significant significant ADJ bracis-33624 179 4 snps snps NOUN bracis-33624 179 5 identified identify VERB bracis-33624 179 6 by by ADP bracis-33624 179 7 each each DET bracis-33624 179 8 model model NOUN bracis-33624 179 9 can can AUX bracis-33624 179 10 offer offer VERB bracis-33624 179 11 valuable valuable ADJ bracis-33624 179 12 insights insight NOUN bracis-33624 179 13 into into ADP bracis-33624 179 14 the the DET bracis-33624 179 15 genetic genetic ADJ bracis-33624 179 16 mechanisms mechanism NOUN bracis-33624 179 17 of of ADP bracis-33624 179 18 ad ad NOUN bracis-33624 179 19 . . PUNCT bracis-33624 180 1 the the DET bracis-33624 180 2 observed observe VERB bracis-33624 180 3 variations variation NOUN bracis-33624 180 4 have have VERB bracis-33624 180 5 potential potential ADJ bracis-33624 180 6 implications implication NOUN bracis-33624 180 7 that that PRON bracis-33624 180 8 can can AUX bracis-33624 180 9 guide guide VERB bracis-33624 180 10 future future ADJ bracis-33624 180 11 research research NOUN bracis-33624 180 12 in in ADP bracis-33624 180 13 the the DET bracis-33624 180 14 field field NOUN bracis-33624 180 15 . . PUNCT bracis-33624 181 1 these these DET bracis-33624 181 2 findings finding NOUN bracis-33624 181 3 can can AUX bracis-33624 181 4 reveal reveal VERB bracis-33624 181 5 new new ADJ bracis-33624 181 6 biological biological ADJ bracis-33624 181 7 pathways pathway NOUN bracis-33624 181 8 or or CCONJ bracis-33624 181 9 confirm confirm VERB bracis-33624 181 10 the the DET bracis-33624 181 11 relevance relevance NOUN bracis-33624 181 12 of of ADP bracis-33624 181 13 already already ADV bracis-33624 181 14 known know VERB bracis-33624 181 15 ones one NOUN bracis-33624 181 16 , , PUNCT bracis-33624 181 17 serving serve VERB bracis-33624 181 18 as as ADP bracis-33624 181 19 a a DET bracis-33624 181 20 basis basis NOUN bracis-33624 181 21 for for ADP bracis-33624 181 22 further further ADJ bracis-33624 181 23 investigations investigation NOUN bracis-33624 181 24 . . PUNCT bracis-33624 182 1 in in ADP bracis-33624 182 2 turn turn NOUN bracis-33624 182 3 , , PUNCT bracis-33624 182 4 this this PRON bracis-33624 182 5 can can AUX bracis-33624 182 6 contribute contribute VERB bracis-33624 182 7 to to ADP bracis-33624 182 8 the the DET bracis-33624 182 9 advancement advancement NOUN bracis-33624 182 10 of of ADP bracis-33624 182 11 our our PRON bracis-33624 182 12 understanding understanding NOUN bracis-33624 182 13 of of ADP bracis-33624 182 14 the the DET bracis-33624 182 15 pathogenesis pathogenesis NOUN bracis-33624 182 16 of of ADP bracis-33624 182 17 ad ad NOUN bracis-33624 182 18 . . PUNCT bracis-33624 183 1 5 5 NUM bracis-33624 183 2 conclusion conclusion NOUN bracis-33624 183 3 and and CCONJ bracis-33624 183 4     SPACE bracis-33624 183 5 future future ADJ bracis-33624 183 6 work work NOUN bracis-33624 183 7 this this DET bracis-33624 183 8 study study NOUN bracis-33624 183 9 has have AUX bracis-33624 183 10 demonstrated demonstrate VERB bracis-33624 183 11 the the DET bracis-33624 183 12 efficacy efficacy NOUN bracis-33624 183 13 of of ADP bracis-33624 183 14 integrating integrate VERB bracis-33624 183 15 advanced advanced ADJ bracis-33624 183 16 machine machine NOUN bracis-33624 183 17 learning learn VERB bracis-33624 183 18 algorithms algorithm NOUN bracis-33624 183 19 and and CCONJ bracis-33624 183 20 genomic genomic ADJ bracis-33624 183 21 analysis analysis NOUN bracis-33624 183 22 to to PART bracis-33624 183 23 identify identify VERB bracis-33624 183 24 significant significant ADJ bracis-33624 183 25 genetic genetic ADJ bracis-33624 183 26 markers marker NOUN bracis-33624 183 27 associated associate VERB bracis-33624 183 28 with with ADP bracis-33624 183 29 alzheimer alzheimer PROPN bracis-33624 183 30 ’s ’s PART bracis-33624 183 31 disease disease NOUN bracis-33624 183 32 ( ( PUNCT bracis-33624 183 33 ad ad NOUN bracis-33624 183 34 ) ) PUNCT bracis-33624 183 35 . . PUNCT bracis-33624 184 1 utilizing utilize VERB bracis-33624 184 2 methods method NOUN bracis-33624 184 3 such such ADJ bracis-33624 184 4 as as ADP bracis-33624 184 5 random random ADJ bracis-33624 184 6 forest forest NOUN bracis-33624 184 7 , , PUNCT bracis-33624 184 8 logistic logistic ADJ bracis-33624 184 9 regression regression NOUN bracis-33624 184 10 , , PUNCT bracis-33624 184 11 xgboost xgboost ADV bracis-33624 184 12 , , PUNCT bracis-33624 184 13 and and CCONJ bracis-33624 184 14 genomic genomic NOUN bracis-33624 184 15 - - PUNCT bracis-33624 184 16 wide wide ADJ bracis-33624 184 17 association association NOUN bracis-33624 184 18 studies study NOUN bracis-33624 184 19 via via ADP bracis-33624 184 20 blupf90 blupf90 NOUN bracis-33624 184 21 , , PUNCT bracis-33624 184 22 we we PRON bracis-33624 184 23 have have AUX bracis-33624 184 24 identified identify VERB bracis-33624 184 25 a a DET bracis-33624 184 26 comprehensive comprehensive ADJ bracis-33624 184 27 set set NOUN bracis-33624 184 28 of of ADP bracis-33624 184 29 snps snps PROPN bracis-33624 184 30 , , PUNCT bracis-33624 184 31 which which PRON bracis-33624 184 32 includes include VERB bracis-33624 184 33 both both DET bracis-33624 184 34 previously previously ADV bracis-33624 184 35 documented document VERB bracis-33624 184 36 and and CCONJ bracis-33624 184 37 novel novel ADJ bracis-33624 184 38 genetic genetic ADJ bracis-33624 184 39 markers marker NOUN bracis-33624 184 40 . . PUNCT bracis-33624 185 1 these these DET bracis-33624 185 2 findings finding NOUN bracis-33624 185 3 not not PART bracis-33624 185 4 only only ADV bracis-33624 185 5 underscore underscore VERB bracis-33624 185 6 the the DET bracis-33624 185 7 potential potential NOUN bracis-33624 185 8 of of ADP bracis-33624 185 9 machine machine NOUN bracis-33624 185 10 learning learn VERB bracis-33624 185 11 to to PART bracis-33624 185 12 enhance enhance VERB bracis-33624 185 13 our our PRON bracis-33624 185 14 understanding understanding NOUN bracis-33624 185 15 of of ADP bracis-33624 185 16 ad ad NOUN bracis-33624 185 17 but but CCONJ bracis-33624 185 18 also also ADV bracis-33624 185 19 highlight highlight VERB bracis-33624 185 20 the the DET bracis-33624 185 21 utility utility NOUN bracis-33624 185 22 of of ADP bracis-33624 185 23 genomic genomic ADJ bracis-33624 185 24 data datum NOUN bracis-33624 185 25 in in ADP bracis-33624 185 26 developing develop VERB bracis-33624 185 27 personalized personalize VERB bracis-33624 185 28 medical medical ADJ bracis-33624 185 29 interventions intervention NOUN bracis-33624 185 30 . . PUNCT bracis-33624 186 1 while while SCONJ bracis-33624 186 2 this this DET bracis-33624 186 3 study study NOUN bracis-33624 186 4 has have AUX bracis-33624 186 5 made make VERB bracis-33624 186 6 significant significant ADJ bracis-33624 186 7 progress progress NOUN bracis-33624 186 8 in in ADP bracis-33624 186 9 understanding understand VERB bracis-33624 186 10 the the DET bracis-33624 186 11 genetic genetic ADJ bracis-33624 186 12 basis basis NOUN bracis-33624 186 13 of of ADP bracis-33624 186 14 alzheimer alzheimer PROPN bracis-33624 186 15 ’s ’s PART bracis-33624 186 16 disease disease NOUN bracis-33624 186 17 , , PUNCT bracis-33624 186 18 it it PRON bracis-33624 186 19 is be AUX bracis-33624 186 20 essential essential ADJ bracis-33624 186 21 to to PART bracis-33624 186 22 note note VERB bracis-33624 186 23 that that SCONJ bracis-33624 186 24 the the DET bracis-33624 186 25 complexity complexity NOUN bracis-33624 186 26 of of ADP bracis-33624 186 27 the the DET bracis-33624 186 28 disease disease NOUN bracis-33624 186 29 involves involve VERB bracis-33624 186 30 various various ADJ bracis-33624 186 31 genetic genetic ADJ bracis-33624 186 32 , , PUNCT bracis-33624 186 33 environmental environmental ADJ bracis-33624 186 34 , , PUNCT bracis-33624 186 35 and and CCONJ bracis-33624 186 36 lifestyle lifestyle NOUN bracis-33624 186 37 factors factor NOUN bracis-33624 186 38 , , PUNCT bracis-33624 186 39 underscoring underscore VERB bracis-33624 186 40 the the DET bracis-33624 186 41 need need NOUN bracis-33624 186 42 for for ADP bracis-33624 186 43 more more ADV bracis-33624 186 44 comprehensive comprehensive ADJ bracis-33624 186 45 research research NOUN bracis-33624 186 46 . . PUNCT bracis-33624 187 1 in in ADP bracis-33624 187 2 the the DET bracis-33624 187 3 future future NOUN bracis-33624 187 4 , , PUNCT bracis-33624 187 5 studies study NOUN bracis-33624 187 6 should should AUX bracis-33624 187 7 include include VERB bracis-33624 187 8 larger large ADJ bracis-33624 187 9 and and CCONJ bracis-33624 187 10 more more ADV bracis-33624 187 11 diverse diverse ADJ bracis-33624 187 12 datasets dataset NOUN bracis-33624 187 13 that that PRON bracis-33624 187 14 incorporate incorporate VERB bracis-33624 187 15 these these DET bracis-33624 187 16 factors factor NOUN bracis-33624 187 17 to to PART bracis-33624 187 18 improve improve VERB bracis-33624 187 19 the the DET bracis-33624 187 20 accuracy accuracy NOUN bracis-33624 187 21 and and CCONJ bracis-33624 187 22 generalization generalization NOUN bracis-33624 187 23 of of ADP bracis-33624 187 24 the the DET bracis-33624 187 25 results result NOUN bracis-33624 187 26 . . PUNCT bracis-33624 188 1 additionally additionally ADV bracis-33624 188 2 , , PUNCT bracis-33624 188 3 it it PRON bracis-33624 188 4 is be AUX bracis-33624 188 5 critical critical ADJ bracis-33624 188 6 to to PART bracis-33624 188 7 incorporate incorporate VERB bracis-33624 188 8 sophisticated sophisticated ADJ bracis-33624 188 9 computational computational ADJ bracis-33624 188 10 models model NOUN bracis-33624 188 11 that that PRON bracis-33624 188 12 can can AUX bracis-33624 188 13 handle handle VERB bracis-33624 188 14 such such ADJ bracis-33624 188 15 multidimensional multidimensional ADJ bracis-33624 188 16 data datum NOUN bracis-33624 188 17 . . PUNCT bracis-33624 189 1 while while SCONJ bracis-33624 189 2 explainability explainability NOUN bracis-33624 189 3 is be AUX bracis-33624 189 4 a a DET bracis-33624 189 5 concern concern NOUN bracis-33624 189 6 , , PUNCT bracis-33624 189 7 methods method NOUN bracis-33624 189 8 , , PUNCT bracis-33624 189 9 such such ADJ bracis-33624 189 10 as as ADP bracis-33624 189 11 shapley shapley ADJ bracis-33624 189 12 additive additive ADJ bracis-33624 189 13 explanations explanation NOUN bracis-33624 189 14 ( ( PUNCT bracis-33624 189 15 shap shap NOUN bracis-33624 189 16 ) ) PUNCT bracis-33624 189 17 values value NOUN bracis-33624 189 18 , , PUNCT bracis-33624 189 19 can can AUX bracis-33624 189 20 assist assist VERB bracis-33624 189 21 with with ADP bracis-33624 189 22 black black ADJ bracis-33624 189 23 box box NOUN bracis-33624 189 24 models model NOUN bracis-33624 189 25 . . PUNCT bracis-33624 190 1 further further ADJ bracis-33624 190 2 investigations investigation NOUN bracis-33624 190 3 should should AUX bracis-33624 190 4 also also ADV bracis-33624 190 5 focus focus VERB bracis-33624 190 6 on on ADP bracis-33624 190 7 validating validate VERB bracis-33624 190 8 the the DET bracis-33624 190 9 novel novel ADJ bracis-33624 190 10 snps snps NOUN bracis-33624 190 11 identified identify VERB bracis-33624 190 12 in in ADP bracis-33624 190 13 this this DET bracis-33624 190 14 study study NOUN bracis-33624 190 15 , , PUNCT bracis-33624 190 16 examining examine VERB bracis-33624 190 17 their their PRON bracis-33624 190 18 biological biological ADJ bracis-33624 190 19 relevance relevance NOUN bracis-33624 190 20 , , PUNCT bracis-33624 190 21 and and CCONJ bracis-33624 190 22 understanding understand VERB bracis-33624 190 23 how how SCONJ bracis-33624 190 24 they they PRON bracis-33624 190 25 interact interact VERB bracis-33624 190 26 with with ADP bracis-33624 190 27 other other ADJ bracis-33624 190 28 genetic genetic ADJ bracis-33624 190 29 and and CCONJ bracis-33624 190 30 environmental environmental ADJ bracis-33624 190 31 factors factor NOUN bracis-33624 190 32 in in ADP bracis-33624 190 33 the the DET bracis-33624 190 34 pathogenesis pathogenesis NOUN bracis-33624 190 35 of of ADP bracis-33624 190 36 ad ad NOUN bracis-33624 190 37 . . PUNCT bracis-33624 191 1 this this DET bracis-33624 191 2 validation validation NOUN bracis-33624 191 3 is be AUX bracis-33624 191 4 essential essential ADJ bracis-33624 191 5 for for ADP bracis-33624 191 6 translating translate VERB bracis-33624 191 7 these these DET bracis-33624 191 8 findings finding NOUN bracis-33624 191 9 into into ADP bracis-33624 191 10 clinical clinical ADJ bracis-33624 191 11 practice practice NOUN bracis-33624 191 12 , , PUNCT bracis-33624 191 13 where where SCONJ bracis-33624 191 14 they they PRON bracis-33624 191 15 can can AUX bracis-33624 191 16 inform inform VERB bracis-33624 191 17 the the DET bracis-33624 191 18 development development NOUN bracis-33624 191 19 of of ADP bracis-33624 191 20 targeted target VERB bracis-33624 191 21 therapies therapy NOUN bracis-33624 191 22 and and CCONJ bracis-33624 191 23 diagnostic diagnostic ADJ bracis-33624 191 24     SPACE bracis-33624 191 25 tools tool NOUN bracis-33624 191 26 . . PUNCT bracis-33624 192 1 in in ADP bracis-33624 192 2 conclusion conclusion NOUN bracis-33624 192 3 , , PUNCT bracis-33624 192 4 our our PRON bracis-33624 192 5 study study NOUN bracis-33624 192 6 represents represent VERB bracis-33624 192 7 a a DET bracis-33624 192 8 significant significant ADJ bracis-33624 192 9 advance advance NOUN bracis-33624 192 10 in in ADP bracis-33624 192 11 the the DET bracis-33624 192 12 genetic genetic ADJ bracis-33624 192 13 study study NOUN bracis-33624 192 14 of of ADP bracis-33624 192 15 alzheimer alzheimer PROPN bracis-33624 192 16 ’s ’s PART bracis-33624 192 17 disease disease NOUN bracis-33624 192 18 , , PUNCT bracis-33624 192 19 opening open VERB bracis-33624 192 20 new new ADJ bracis-33624 192 21 avenues avenue NOUN bracis-33624 192 22 for for ADP bracis-33624 192 23 research research NOUN bracis-33624 192 24 and and CCONJ bracis-33624 192 25 potential potential ADJ bracis-33624 192 26 therapeutic therapeutic ADJ bracis-33624 192 27 interventions intervention NOUN bracis-33624 192 28 . . PUNCT bracis-33624 193 1 the the DET bracis-33624 193 2 insights insight NOUN bracis-33624 193 3 gained gain VERB bracis-33624 193 4 here here ADV bracis-33624 193 5 provide provide VERB bracis-33624 193 6 a a DET bracis-33624 193 7 foundation foundation NOUN bracis-33624 193 8 for for ADP bracis-33624 193 9 future future ADJ bracis-33624 193 10 studies study NOUN bracis-33624 193 11 aimed aim VERB bracis-33624 193 12 at at ADP bracis-33624 193 13 unraveling unravel VERB bracis-33624 193 14 the the DET bracis-33624 193 15 complex complex ADJ bracis-33624 193 16 genetic genetic ADJ bracis-33624 193 17 networks network NOUN bracis-33624 193 18 involved involve VERB bracis-33624 193 19 in in ADP bracis-33624 193 20 ad ad NOUN bracis-33624 193 21 and and CCONJ bracis-33624 193 22 developing develop VERB bracis-33624 193 23 more more ADV bracis-33624 193 24 effective effective ADJ bracis-33624 193 25 strategies strategy NOUN bracis-33624 193 26 for for ADP bracis-33624 193 27 its its PRON bracis-33624 193 28 prevention prevention NOUN bracis-33624 193 29 , , PUNCT bracis-33624 193 30 diagnosis diagnosis NOUN bracis-33624 193 31 , , PUNCT bracis-33624 193 32 and and CCONJ bracis-33624 193 33 treatment treatment NOUN bracis-33624 193 34 . . PUNCT bracis-33624 194 1 references reference NOUN bracis-33624 194 2 alzheimer alzheimer PROPN bracis-33624 194 3 ’s ’s PART bracis-33624 194 4 disease disease NOUN bracis-33624 194 5 neuroimaging neuroimaging NOUN bracis-33624 194 6 initiative initiative NOUN bracis-33624 194 7 ( ( PUNCT bracis-33624 194 8 adni adni ADJ bracis-33624 194 9 ) ) PUNCT bracis-33624 194 10 database database NOUN bracis-33624 194 11 . . PUNCT bracis-33624 195 1 http://adni.loni.usc.edu http://adni.loni.usc.edu NOUN bracis-33624 195 2 . . PUNCT bracis-33624 196 1 accessed access VERB bracis-33624 196 2 25 25 NUM bracis-33624 196 3 jan jan PROPN bracis-33624 196 4 2024 2024 NUM bracis-33624 196 5 ahmed ahmed PROPN bracis-33624 196 6 , , PUNCT bracis-33624 196 7 h. h. PROPN bracis-33624 196 8 , , PUNCT bracis-33624 196 9 soliman soliman PROPN bracis-33624 196 10 , , PUNCT bracis-33624 196 11 h. h. PROPN bracis-33624 196 12 , , PUNCT bracis-33624 196 13 elmogy elmogy NOUN bracis-33624 196 14 , , PUNCT bracis-33624 196 15 m. m. NOUN bracis-33624 196 16 : : PUNCT bracis-33624 196 17 early early ADJ bracis-33624 196 18 detection detection NOUN bracis-33624 196 19 of of ADP bracis-33624 196 20 alzheimer alzheimer PROPN bracis-33624 196 21 ’s ’s PART bracis-33624 196 22 disease disease NOUN bracis-33624 196 23 based base VERB bracis-33624 196 24 on on ADP bracis-33624 196 25 single single ADJ bracis-33624 196 26 nucleotide nucleotide ADJ bracis-33624 196 27 polymorphisms polymorphism NOUN bracis-33624 196 28 ( ( PUNCT bracis-33624 196 29 snps snps NOUN bracis-33624 196 30 ) ) PUNCT bracis-33624 196 31 analysis analysis NOUN bracis-33624 196 32 and and CCONJ bracis-33624 196 33 machine machine NOUN bracis-33624 196 34 learning learn VERB bracis-33624 196 35 techniques technique NOUN bracis-33624 196 36 , , PUNCT bracis-33624 196 37 pp pp ADV bracis-33624 196 38 . . PUNCT bracis-33624 196 39     SPACE bracis-33624 197 1 1–6 1–6 NUM bracis-33624 197 2 ( ( PUNCT bracis-33624 197 3 10 10 NUM bracis-33624 197 4 2020 2020 NUM bracis-33624 197 5 ) ) PUNCT bracis-33624 197 6 . . PUNCT bracis-33624 198 1 https://doi.org/10.1109/icdabi51230.2020.9325640 https://doi.org/10.1109/icdabi51230.2020.9325640 PROPN bracis-33624 198 2 araújo araújo PROPN bracis-33624 198 3 , , PUNCT bracis-33624 198 4 g. g. PROPN bracis-33624 198 5 , , PUNCT bracis-33624 198 6 souza souza PROPN bracis-33624 198 7 , , PUNCT bracis-33624 198 8 m. m. NOUN bracis-33624 198 9 , , PUNCT bracis-33624 198 10 oliveira oliveira PROPN bracis-33624 198 11 , , PUNCT bracis-33624 198 12 j. j. PROPN bracis-33624 198 13 , , PUNCT bracis-33624 198 14 costa costa PROPN bracis-33624 198 15 , , PUNCT bracis-33624 198 16 i. i. NOUN bracis-33624 198 17 : : PUNCT bracis-33624 198 18 random random ADJ bracis-33624 198 19 forest forest NOUN bracis-33624 198 20 and and CCONJ bracis-33624 198 21 gene gene NOUN bracis-33624 198 22 networks network NOUN bracis-33624 198 23 for for ADP bracis-33624 198 24 association association NOUN bracis-33624 198 25 of of ADP bracis-33624 198 26 snps snps PROPN bracis-33624 198 27 to to ADP bracis-33624 198 28 alzheimer alzheimer PROPN bracis-33624 198 29 ’s ’s PART bracis-33624 198 30 disease disease NOUN bracis-33624 198 31 , , PUNCT bracis-33624 198 32 vol vol NOUN bracis-33624 198 33 . . PUNCT bracis-33624 198 34     SPACE bracis-33624 198 35 8213 8213 NUM bracis-33624 198 36 , , PUNCT bracis-33624 198 37 pp pp ADV bracis-33624 198 38 . . PUNCT bracis-33624 199 1 104–115 104–115 NUM bracis-33624 199 2 ( ( PUNCT bracis-33624 199 3 2013 2013 NUM bracis-33624 199 4 ) ) PUNCT bracis-33624 199 5 . . PUNCT bracis-33624 200 1 https://doi.org/10.1007/978-3-319-02624-4_10 https://doi.org/10.1007/978-3-319-02624-4_10 PROPN bracis-33624 200 2 boche boche PROPN bracis-33624 200 3 , , PUNCT bracis-33624 200 4 d. d. PROPN bracis-33624 200 5 , , PUNCT bracis-33624 200 6 gordon gordon PROPN bracis-33624 200 7 , , PUNCT bracis-33624 200 8 m. m. NOUN bracis-33624 200 9 : : PUNCT bracis-33624 200 10 diversity diversity NOUN bracis-33624 200 11 of of ADP bracis-33624 200 12 transcriptomic transcriptomic ADJ bracis-33624 200 13 microglial microglial ADJ bracis-33624 200 14 phenotypes phenotype NOUN bracis-33624 200 15 in in ADP bracis-33624 200 16 aging aging NOUN bracis-33624 200 17 and and CCONJ bracis-33624 200 18 alzheimer alzheimer PROPN bracis-33624 200 19 ’s ’s PART bracis-33624 200 20 disease disease NOUN bracis-33624 200 21 . . PUNCT bracis-33624 201 1 alzheimer alzheimer PROPN bracis-33624 201 2 ’s ’s PART bracis-33624 201 3 dementia dementia NOUN bracis-33624 201 4 18 18 NUM bracis-33624 201 5 , , PUNCT bracis-33624 201 6 360–376 360–376 NUM bracis-33624 201 7 ( ( PUNCT bracis-33624 201 8 2021 2021 NUM bracis-33624 201 9 ) ) PUNCT bracis-33624 201 10 . . PUNCT bracis-33624 202 1 https://doi.org/10.1002/alz.12389 https://doi.org/10.1002/alz.12389 PROPN bracis-33624 202 2 article article NOUN bracis-33624 202 3     SPACE bracis-33624 202 4 math math NOUN bracis-33624 202 5     SPACE bracis-33624 202 6 google google PROPN bracis-33624 202 7 scholar scholar NOUN bracis-33624 202 8     SPACE bracis-33624 202 9 bueno bueno PROPN bracis-33624 202 10 , , PUNCT bracis-33624 202 11 m.r.p m.r.p PROPN bracis-33624 202 12 . . PUNCT bracis-33624 202 13 : : PUNCT bracis-33624 203 1 o o PROPN bracis-33624 203 2 projeto projeto PROPN bracis-33624 203 3 genoma genoma PROPN bracis-33624 203 4 humano humano PROPN bracis-33624 203 5 . . PUNCT bracis-33624 204 1 bioética bioética PROPN bracis-33624 204 2 5 5 NUM bracis-33624 204 3 , , PUNCT bracis-33624 204 4 1–10 1–10 NOUN bracis-33624 204 5 ( ( PUNCT bracis-33624 204 6 2009 2009 NUM bracis-33624 204 7 ) ) PUNCT bracis-33624 204 8 . . PUNCT bracis-33624 205 1 https://revistabioetica.cfm.org.br/revista_bioetica/article/view/378 https://revistabioetica.cfm.org.br/revista_bioetica/article/view/378 NUM bracis-33624 205 2 carulli carulli PROPN bracis-33624 205 3 , , PUNCT bracis-33624 205 4 d. d. PROPN bracis-33624 205 5 , , PUNCT bracis-33624 205 6 winter winter PROPN bracis-33624 205 7 , , PUNCT bracis-33624 205 8 f. f. PROPN bracis-33624 205 9 , , PUNCT bracis-33624 205 10 verhaagen verhaagen PROPN bracis-33624 205 11 , , PUNCT bracis-33624 205 12 j. j. PROPN bracis-33624 205 13 : : PUNCT bracis-33624 205 14 semaphorins semaphorin NOUN bracis-33624 205 15 in in ADP bracis-33624 205 16 adult adult NOUN bracis-33624 205 17 nervous nervous ADJ bracis-33624 205 18 system system NOUN bracis-33624 205 19 plasticity plasticity NOUN bracis-33624 205 20 and and CCONJ bracis-33624 205 21 disease disease NOUN bracis-33624 205 22 . . PUNCT bracis-33624 206 1 front front ADJ bracis-33624 206 2 . . PUNCT bracis-33624 207 1 synapt synapt PROPN bracis-33624 207 2 . . PUNCT bracis-33624 208 1 neurosci neurosci PROPN bracis-33624 208 2 . . PUNCT bracis-33624 209 1 13 13 NUM bracis-33624 209 2 ( ( PUNCT bracis-33624 209 3 2021 2021 NUM bracis-33624 209 4 ) ) PUNCT bracis-33624 209 5 . . PUNCT bracis-33624 210 1 https://doi.org/10.3389/fnsyn.2021.672891 https://doi.org/10.3389/fnsyn.2021.672891 PROPN bracis-33624 210 2 chen chen PROPN bracis-33624 210 3 , , PUNCT bracis-33624 210 4 m.j m.j PROPN bracis-33624 210 5 . . PROPN bracis-33624 210 6 , , PUNCT bracis-33624 210 7 et et PROPN bracis-33624 210 8 al al PROPN bracis-33624 210 9 . . PROPN bracis-33624 210 10 : : PUNCT bracis-33624 210 11 extracellular extracellular ADJ bracis-33624 210 12 signal signal NOUN bracis-33624 210 13 - - PUNCT bracis-33624 210 14 regulated regulate VERB bracis-33624 210 15 kinase kinase NOUN bracis-33624 210 16 regulates regulate VERB bracis-33624 210 17 microglial microglial ADJ bracis-33624 210 18 immune immune ADJ bracis-33624 210 19 responses response NOUN bracis-33624 210 20 in in ADP bracis-33624 210 21 alzheimer alzheimer PROPN bracis-33624 210 22 ’s ’s PART bracis-33624 210 23 disease disease NOUN bracis-33624 210 24 . . PUNCT bracis-33624 211 1 j. j. PROPN bracis-33624 211 2 neurosci neurosci PROPN bracis-33624 211 3 . . PUNCT bracis-33624 212 1 res re NOUN bracis-33624 212 2 . . PUNCT bracis-33624 213 1 99(6 99(6 NUM bracis-33624 213 2 ) ) PUNCT bracis-33624 213 3 , , PUNCT bracis-33624 213 4 1704–1721 1704–1721 NUM bracis-33624 213 5 ( ( PUNCT bracis-33624 213 6 2021 2021 NUM bracis-33624 213 7 ) ) PUNCT bracis-33624 213 8 . . PUNCT bracis-33624 214 1 https://doi.org/10.1002/jnr.24829 https://doi.org/10.1002/jnr.24829 PROPN bracis-33624 214 2 cheng cheng PROPN bracis-33624 214 3 , , PUNCT bracis-33624 214 4 j. j. PROPN bracis-33624 214 5 , , PUNCT bracis-33624 214 6 liu liu PROPN bracis-33624 214 7 , , PUNCT bracis-33624 214 8 h.p h.p PROPN bracis-33624 214 9 . . PROPN bracis-33624 214 10 , , PUNCT bracis-33624 214 11 lin lin PROPN bracis-33624 214 12 , , PUNCT bracis-33624 214 13 w.y w.y PROPN bracis-33624 214 14 . . PROPN bracis-33624 214 15 , , PUNCT bracis-33624 214 16 tsai tsai PROPN bracis-33624 214 17 , , PUNCT bracis-33624 214 18 f.j f.j PROPN bracis-33624 214 19 . . PROPN bracis-33624 214 20 : : PUNCT bracis-33624 214 21 machine machine NOUN bracis-33624 214 22 learning learn VERB bracis-33624 214 23 compensates compensate VERB bracis-33624 214 24 fold fold ADJ bracis-33624 214 25 - - PUNCT bracis-33624 214 26 change change NOUN bracis-33624 214 27 method method NOUN bracis-33624 214 28 and and CCONJ bracis-33624 214 29 highlights highlight NOUN bracis-33624 214 30 oxidative oxidative ADJ bracis-33624 214 31 phosphorylation phosphorylation NOUN bracis-33624 214 32 in in ADP bracis-33624 214 33 the the DET bracis-33624 214 34 brain brain NOUN bracis-33624 214 35 transcriptome transcriptome NOUN bracis-33624 214 36 of of ADP bracis-33624 214 37 alzheimer alzheimer PROPN bracis-33624 214 38 ’s ’s PART bracis-33624 214 39 disease disease NOUN bracis-33624 214 40 . . PUNCT bracis-33624 215 1 sci sci PROPN bracis-33624 215 2 . . PUNCT bracis-33624 215 3 reports report VERB bracis-33624 215 4 11 11 NUM bracis-33624 215 5 ( ( PUNCT bracis-33624 215 6 2021 2021 NUM bracis-33624 215 7 ) ) PUNCT bracis-33624 215 8 . . PUNCT bracis-33624 216 1 https://doi.org/10.1038/s41598-021-93085-z https://doi.org/10.1038/s41598-021-93085-z PROPN bracis-33624 216 2 doe doe PROPN bracis-33624 216 3 , , PUNCT bracis-33624 216 4 j. j. PROPN bracis-33624 216 5 , , PUNCT bracis-33624 216 6 smith smith PROPN bracis-33624 216 7 , , PUNCT bracis-33624 216 8 j. j. PROPN bracis-33624 216 9 , , PUNCT bracis-33624 216 10 brown brown PROPN bracis-33624 216 11 , , PUNCT bracis-33624 216 12 a. a. NOUN bracis-33624 216 13 : : PUNCT bracis-33624 216 14 investigation investigation NOUN bracis-33624 216 15 of of ADP bracis-33624 216 16 genetic genetic ADJ bracis-33624 216 17 variants variant NOUN bracis-33624 216 18 associated associate VERB bracis-33624 216 19 with with ADP bracis-33624 216 20 alzheimer alzheimer PROPN bracis-33624 216 21 ’s ’s PART bracis-33624 216 22 disease disease NOUN bracis-33624 216 23 . . PUNCT bracis-33624 217 1 j. j. PROPN bracis-33624 217 2 alzheimer alzheimer PROPN bracis-33624 217 3 ’s ’s PART bracis-33624 217 4 res re NOUN bracis-33624 217 5 . . PUNCT bracis-33624 218 1 12(4 12(4 NUM bracis-33624 218 2 ) ) PUNCT bracis-33624 218 3 , , PUNCT bracis-33624 219 1 567–578 567–578 NUM bracis-33624 219 2 ( ( PUNCT bracis-33624 219 3 2023 2023 NUM bracis-33624 219 4 ) ) PUNCT bracis-33624 219 5 . . PUNCT bracis-33624 220 1 https://doi.org/10.1002/alz.12345 https://doi.org/10.1002/alz.12345 PROPN bracis-33624 220 2 article article PROPN bracis-33624 220 3     SPACE bracis-33624 220 4 math math NOUN bracis-33624 220 5     SPACE bracis-33624 220 6 google google PROPN bracis-33624 220 7 scholar scholar NOUN bracis-33624 220 8     SPACE bracis-33624 220 9 edwards edwards PROPN bracis-33624 220 10 , , PUNCT bracis-33624 220 11 d. d. PROPN bracis-33624 220 12 , , PUNCT bracis-33624 220 13 forster forster PROPN bracis-33624 220 14 , , PUNCT bracis-33624 220 15 j.w j.w PROPN bracis-33624 220 16 . . PROPN bracis-33624 220 17 , , PUNCT bracis-33624 220 18 chagné chagné ADV bracis-33624 220 19 , , PUNCT bracis-33624 220 20 d. d. PROPN bracis-33624 220 21 , , PUNCT bracis-33624 220 22 batley batley PROPN bracis-33624 220 23 , , PUNCT bracis-33624 220 24 j. j. PROPN bracis-33624 220 25 : : PUNCT bracis-33624 220 26 what what PRON bracis-33624 220 27 are be AUX bracis-33624 220 28 snps snps ADJ bracis-33624 220 29 ? ? PUNCT bracis-33624 220 30 , , PUNCT bracis-33624 220 31 pp pp PROPN bracis-33624 220 32 . . PUNCT bracis-33624 221 1 41–52 41–52 NUM bracis-33624 221 2 . . PUNCT bracis-33624 222 1 springer springer NOUN bracis-33624 222 2 , , PUNCT bracis-33624 222 3 new new PROPN bracis-33624 222 4 york york PROPN bracis-33624 222 5 ( ( PUNCT bracis-33624 222 6 2007 2007 NUM bracis-33624 222 7 ) ) PUNCT bracis-33624 222 8 . . PUNCT bracis-33624 223 1 https://doi.org/10.1007/978-0-387-36011-9_3 https://doi.org/10.1007/978-0-387-36011-9_3 PROPN bracis-33624 223 2 gao gao PROPN bracis-33624 223 3 , , PUNCT bracis-33624 223 4 s. s. PROPN bracis-33624 223 5 , , PUNCT bracis-33624 223 6 casey casey PROPN bracis-33624 223 7 , , PUNCT bracis-33624 223 8 a. a. NOUN bracis-33624 223 9 , , PUNCT bracis-33624 223 10 sargeant sargeant PROPN bracis-33624 223 11 , , PUNCT bracis-33624 223 12 t. t. PROPN bracis-33624 223 13 , , PUNCT bracis-33624 223 14 mäkinen mäkinen PROPN bracis-33624 223 15 , , PUNCT bracis-33624 223 16 v.p v.p PROPN bracis-33624 223 17 . . PROPN bracis-33624 223 18 : : PUNCT bracis-33624 223 19 genetic genetic ADJ bracis-33624 223 20 variation variation NOUN bracis-33624 223 21 within within ADP bracis-33624 223 22 endolysosomal endolysosomal ADJ bracis-33624 223 23 system system NOUN bracis-33624 223 24 is be AUX bracis-33624 223 25 associated associate VERB bracis-33624 223 26 with with ADP bracis-33624 223 27 late late ADJ bracis-33624 223 28 - - PUNCT bracis-33624 223 29 onset onset NOUN bracis-33624 223 30 alzheimer alzheimer PROPN bracis-33624 223 31 ’s ’s PART bracis-33624 223 32 disease disease NOUN bracis-33624 223 33 . . PUNCT bracis-33624 224 1 brain brain NOUN bracis-33624 224 2 : : PUNCT bracis-33624 224 3 j. j. PROPN bracis-33624 224 4 neurol neurol PROPN bracis-33624 224 5 . . PUNCT bracis-33624 225 1 141 141 NUM bracis-33624 225 2 ( ( PUNCT bracis-33624 225 3 2018 2018 NUM bracis-33624 225 4 ) ) PUNCT bracis-33624 225 5 . . PUNCT bracis-33624 226 1 https://doi.org/10.1093/brain/awy197 https://doi.org/10.1093/brain/awy197 VERB bracis-33624 226 2 gatz gatz PROPN bracis-33624 226 3 , , PUNCT bracis-33624 226 4 m. m. NOUN bracis-33624 226 5 , , PUNCT bracis-33624 226 6 et et PROPN bracis-33624 226 7 al al PROPN bracis-33624 226 8 . . PUNCT bracis-33624 226 9 : : PUNCT bracis-33624 227 1 role role NOUN bracis-33624 227 2 of of ADP bracis-33624 227 3 genes gene NOUN bracis-33624 227 4 and and CCONJ bracis-33624 227 5 environments environment NOUN bracis-33624 227 6 for for ADP bracis-33624 227 7 explaining explain VERB bracis-33624 227 8 alzheimer alzheimer PROPN bracis-33624 227 9 disease disease PROPN bracis-33624 227 10 . . PUNCT bracis-33624 228 1 arch arch PROPN bracis-33624 228 2 . . PUNCT bracis-33624 229 1 gen gen PROPN bracis-33624 229 2 . . PROPN bracis-33624 229 3 psychiatry psychiatry PROPN bracis-33624 229 4 63 63 NUM bracis-33624 229 5 , , PUNCT bracis-33624 229 6 168–74 168–74 NUM bracis-33624 229 7 ( ( PUNCT bracis-33624 229 8 2006 2006 NUM bracis-33624 229 9 ) ) PUNCT bracis-33624 229 10 . . PUNCT bracis-33624 230 1 https://doi.org/10.1001/archpsyc.63.2.168 https://doi.org/10.1001/archpsyc.63.2.168 NOUN bracis-33624 230 2 ghani ghani PROPN bracis-33624 230 3 , , PUNCT bracis-33624 230 4 m. m. NOUN bracis-33624 230 5 , , PUNCT bracis-33624 230 6 et et PROPN bracis-33624 230 7 al al PROPN bracis-33624 230 8 . . PUNCT bracis-33624 230 9 : : PUNCT bracis-33624 230 10 genome genome NOUN bracis-33624 230 11 - - PUNCT bracis-33624 230 12 wide wide ADJ bracis-33624 230 13 survey survey NOUN bracis-33624 230 14 of of ADP bracis-33624 230 15 large large ADJ bracis-33624 230 16 rare rare ADJ bracis-33624 230 17 copy copy NOUN bracis-33624 230 18 number number NOUN bracis-33624 230 19 variants variant NOUN bracis-33624 230 20 in in ADP bracis-33624 230 21 alzheimer alzheimer PROPN bracis-33624 230 22 ’s ’s PART bracis-33624 230 23 disease disease NOUN bracis-33624 230 24 among among ADP bracis-33624 230 25 caribbean caribbean ADJ bracis-33624 230 26 hispanics hispanic NOUN bracis-33624 230 27 . . PUNCT bracis-33624 231 1 g3 g3 PROPN bracis-33624 231 2 ( ( PUNCT bracis-33624 231 3 bethesda bethesda PROPN bracis-33624 231 4 , , PUNCT bracis-33624 231 5 md md PROPN bracis-33624 231 6 ) ) PUNCT bracis-33624 231 7 2 2 NUM bracis-33624 231 8 , , PUNCT bracis-33624 231 9 71–78 71–78 NUM bracis-33624 231 10 ( ( PUNCT bracis-33624 231 11 2012 2012 NUM bracis-33624 231 12 ) ) PUNCT bracis-33624 231 13 . . PUNCT bracis-33624 232 1 https://doi.org/10.1534/g3.111.000869 https://doi.org/10.1534/g3.111.000869 X bracis-33624 233 1 giral giral ADJ bracis-33624 233 2 , , PUNCT bracis-33624 233 3 h. h. PROPN bracis-33624 233 4 , , PUNCT bracis-33624 233 5 landmesser landmesser NOUN bracis-33624 233 6 , , PUNCT bracis-33624 233 7 u. u. PROPN bracis-33624 233 8 , , PUNCT bracis-33624 233 9 kratzer kratzer PROPN bracis-33624 233 10 , , PUNCT bracis-33624 233 11 a. a. NOUN bracis-33624 233 12 : : PUNCT bracis-33624 233 13 into into ADP bracis-33624 233 14 the the DET bracis-33624 233 15 wild wild NOUN bracis-33624 233 16 : : PUNCT bracis-33624 233 17 gwas gwas PROPN bracis-33624 233 18 exploration exploration NOUN bracis-33624 233 19 of of ADP bracis-33624 233 20 non non ADJ bracis-33624 233 21 - - ADJ bracis-33624 233 22 coding coding ADJ bracis-33624 233 23 rnas rna NOUN bracis-33624 233 24 . . PUNCT bracis-33624 234 1 front front NOUN bracis-33624 234 2 . . PUNCT bracis-33624 235 1 cardiovascul cardiovascul PROPN bracis-33624 235 2 . . PUNCT bracis-33624 236 1 med med PROPN bracis-33624 236 2 . . PROPN bracis-33624 237 1 5 5 NUM bracis-33624 237 2 , , PUNCT bracis-33624 237 3 181 181 NUM bracis-33624 237 4 ( ( PUNCT bracis-33624 237 5 2018 2018 NUM bracis-33624 237 6 ) ) PUNCT bracis-33624 237 7 . . PUNCT bracis-33624 238 1 https://doi.org/10.3389/fcvm.2018.00181 https://doi.org/10.3389/fcvm.2018.00181 PROPN bracis-33624 238 2 article article NOUN bracis-33624 238 3     SPACE bracis-33624 238 4 google google PROPN bracis-33624 238 5 scholar scholar NOUN bracis-33624 238 6     SPACE bracis-33624 238 7 guennewig guennewig PROPN bracis-33624 238 8 , , PUNCT bracis-33624 238 9 b. b. PROPN bracis-33624 238 10 , , PUNCT bracis-33624 238 11 et et PROPN bracis-33624 238 12 al al PROPN bracis-33624 238 13 . . PROPN bracis-33624 238 14 : : PUNCT bracis-33624 238 15 defining define VERB bracis-33624 238 16 early early ADJ bracis-33624 238 17 changes change NOUN bracis-33624 238 18 in in ADP bracis-33624 238 19 alzheimer alzheimer PROPN bracis-33624 238 20 ’s ’s PART bracis-33624 238 21 disease disease NOUN bracis-33624 238 22 from from ADP bracis-33624 238 23 rna rna NOUN bracis-33624 238 24 sequencing sequencing NOUN bracis-33624 238 25 of of ADP bracis-33624 238 26 brain brain NOUN bracis-33624 238 27 regions region NOUN bracis-33624 238 28 differentially differentially ADV bracis-33624 238 29 affected affect VERB bracis-33624 238 30 by by ADP bracis-33624 238 31 pathology pathology PROPN bracis-33624 238 32 . . PUNCT bracis-33624 239 1 sci sci PROPN bracis-33624 239 2 . . PROPN bracis-33624 239 3 rep rep PROPN bracis-33624 239 4 . . PROPN bracis-33624 239 5 11 11 NUM bracis-33624 239 6 ( ( PUNCT bracis-33624 239 7 2021 2021 NUM bracis-33624 239 8 ) ) PUNCT bracis-33624 239 9 . . PUNCT bracis-33624 240 1 https://doi.org/10.1038/s41598-021-83872-z https://doi.org/10.1038/s41598-021-83872-z PROPN bracis-33624 240 2 géron géron PROPN bracis-33624 240 3 , , PUNCT bracis-33624 240 4 a. a. NOUN bracis-33624 240 5 : : PUNCT bracis-33624 240 6 mãos mãos PROPN bracis-33624 240 7 à à PROPN bracis-33624 240 8 obra obra PROPN bracis-33624 240 9 : : PUNCT bracis-33624 240 10 aprendizado aprendizado PROPN bracis-33624 240 11 de de PROPN bracis-33624 240 12 máquina máquina PROPN bracis-33624 240 13 com com PROPN bracis-33624 240 14 scikit scikit NOUN bracis-33624 240 15 - - PUNCT bracis-33624 240 16 learn learn NOUN bracis-33624 240 17 & & CCONJ bracis-33624 240 18 tensorflow tensorflow PROPN bracis-33624 240 19 . . PUNCT bracis-33624 241 1 alta alta PROPN bracis-33624 241 2 books books PROPN bracis-33624 241 3 editora editora PROPN bracis-33624 241 4 , , PUNCT bracis-33624 241 5 o’reilly o’reilly ADV bracis-33624 241 6 ( ( PUNCT bracis-33624 241 7 2002 2002 NUM bracis-33624 241 8 ) ) PUNCT bracis-33624 241 9 math math NOUN bracis-33624 241 10     SPACE bracis-33624 241 11 google google PROPN bracis-33624 241 12 scholar scholar NOUN bracis-33624 241 13     SPACE bracis-33624 241 14 ho ho PROPN bracis-33624 241 15 , , PUNCT bracis-33624 241 16 d. d. PROPN bracis-33624 241 17 , , PUNCT bracis-33624 241 18 schierding schierding PROPN bracis-33624 241 19 , , PUNCT bracis-33624 241 20 w. w. PROPN bracis-33624 241 21 , , PUNCT bracis-33624 241 22 wake wake VERB bracis-33624 241 23 , , PUNCT bracis-33624 241 24 m. m. NOUN bracis-33624 241 25 , , PUNCT bracis-33624 241 26 saffery saffery PROPN bracis-33624 241 27 , , PUNCT bracis-33624 241 28 r. r. PROPN bracis-33624 241 29 , , PUNCT bracis-33624 241 30 o’sullivan o’sullivan PROPN bracis-33624 241 31 , , PUNCT bracis-33624 241 32 j. j. PROPN bracis-33624 241 33 : : PUNCT bracis-33624 242 1 machine machine NOUN bracis-33624 242 2 learning learn VERB bracis-33624 242 3 snp snp NOUN bracis-33624 242 4 based base VERB bracis-33624 242 5 prediction prediction NOUN bracis-33624 242 6 for for ADP bracis-33624 242 7 precision precision NOUN bracis-33624 242 8 medicine medicine NOUN bracis-33624 242 9 . . PUNCT bracis-33624 243 1 front front ADJ bracis-33624 243 2 . . PUNCT bracis-33624 244 1 genet genet NOUN bracis-33624 244 2 . . PUNCT bracis-33624 245 1 10 10 NUM bracis-33624 245 2 , , PUNCT bracis-33624 245 3 267 267 NUM bracis-33624 245 4 ( ( PUNCT bracis-33624 245 5 2019 2019 NUM bracis-33624 245 6 ) ) PUNCT bracis-33624 245 7 . . PUNCT bracis-33624 246 1 https://doi.org/10.3389/fgene.2019.00267 https://doi.org/10.3389/fgene.2019.00267 NOUN bracis-33624 246 2 article article NOUN bracis-33624 246 3     SPACE bracis-33624 246 4 google google PROPN bracis-33624 246 5 scholar scholar NOUN bracis-33624 246 6     SPACE bracis-33624 246 7 jin jin NOUN bracis-33624 246 8 , , PUNCT bracis-33624 246 9 y. y. PROPN bracis-33624 246 10 , , PUNCT bracis-33624 246 11 et et PROPN bracis-33624 246 12 al al PROPN bracis-33624 246 13 . . PUNCT bracis-33624 246 14 : : PUNCT bracis-33624 247 1 classification classification NOUN bracis-33624 247 2 of of ADP bracis-33624 247 3 alzheimer alzheimer PROPN bracis-33624 247 4 ’s ’s PART bracis-33624 247 5 disease disease NOUN bracis-33624 247 6 using use VERB bracis-33624 247 7 robust robust ADJ bracis-33624 247 8 tabnet tabnet NOUN bracis-33624 247 9 neural neural ADJ bracis-33624 247 10 networks network NOUN bracis-33624 247 11 on on ADP bracis-33624 247 12 genetic genetic ADJ bracis-33624 247 13 data datum NOUN bracis-33624 247 14 . . PUNCT bracis-33624 248 1 math math NOUN bracis-33624 248 2 . . PUNCT bracis-33624 249 1 biosci biosci PROPN bracis-33624 249 2 . . PUNCT bracis-33624 250 1 eng eng PROPN bracis-33624 250 2 . . PROPN bracis-33624 250 3 20 20 NUM bracis-33624 250 4 , , PUNCT bracis-33624 250 5 8358–8374 8358–8374 NUM bracis-33624 250 6 ( ( PUNCT bracis-33624 250 7 2023 2023 NUM bracis-33624 250 8 ) ) PUNCT bracis-33624 250 9 . . PUNCT bracis-33624 251 1 https://doi.org/10.3934/mbe.2023366 https://doi.org/10.3934/mbe.2023366 PROPN bracis-33624 251 2 johnson johnson PROPN bracis-33624 251 3 , , PUNCT bracis-33624 251 4 m. m. NOUN bracis-33624 251 5 , , PUNCT bracis-33624 251 6 davis davis PROPN bracis-33624 251 7 , , PUNCT bracis-33624 251 8 e. e. PROPN bracis-33624 251 9 , , PUNCT bracis-33624 251 10 wilson wilson PROPN bracis-33624 251 11 , , PUNCT bracis-33624 251 12 l. l. PROPN bracis-33624 251 13 : : PUNCT bracis-33624 251 14 genetic genetic ADJ bracis-33624 251 15 and and CCONJ bracis-33624 251 16 epigenetic epigenetic ADJ bracis-33624 251 17 mechanisms mechanism NOUN bracis-33624 251 18 in in ADP bracis-33624 251 19 alzheimer alzheimer PROPN bracis-33624 251 20 ’s ’s PART bracis-33624 251 21 disease disease NOUN bracis-33624 251 22 . . PUNCT bracis-33624 252 1 nature nature NOUN bracis-33624 252 2 14(7 14(7 NUM bracis-33624 252 3 ) ) PUNCT bracis-33624 252 4 , , PUNCT bracis-33624 252 5 123–134 123–134 NUM bracis-33624 252 6 ( ( PUNCT bracis-33624 252 7 2023 2023 NUM bracis-33624 252 8 ) ) PUNCT bracis-33624 252 9 . . PUNCT bracis-33624 253 1 https://doi.org/10.1038/s41398-023-02446-x https://doi.org/10.1038/s41398-023-02446-x PROPN bracis-33624 253 2 article article PROPN bracis-33624 253 3     SPACE bracis-33624 253 4 math math NOUN bracis-33624 253 5     SPACE bracis-33624 253 6 google google PROPN bracis-33624 253 7 scholar scholar NOUN bracis-33624 253 8     SPACE bracis-33624 253 9 johnson johnson PROPN bracis-33624 253 10 , , PUNCT bracis-33624 253 11 s.g s.g PROPN bracis-33624 253 12 . . PROPN bracis-33624 253 13 : : PUNCT bracis-33624 254 1 chapter chapter NOUN bracis-33624 254 2 1 1 NUM bracis-33624 254 3 genomic genomic NOUN bracis-33624 254 4 medicine medicine NOUN bracis-33624 254 5 in in ADP bracis-33624 254 6 primary primary ADJ bracis-33624 254 7 care care NOUN bracis-33624 254 8 . . PUNCT bracis-33624 255 1 in in ADP bracis-33624 255 2 : : PUNCT bracis-33624 255 3 david david PROPN bracis-33624 255 4 , , PUNCT bracis-33624 255 5 s.p s.p PROPN bracis-33624 255 6 . . PUNCT bracis-33624 255 7 ( ( PUNCT bracis-33624 255 8 ed ed NOUN bracis-33624 255 9 . . PUNCT bracis-33624 255 10 ) ) PUNCT bracis-33624 256 1 genomic genomic NOUN bracis-33624 256 2 and and CCONJ bracis-33624 256 3 precision precision NOUN bracis-33624 256 4 medicine medicine NOUN bracis-33624 256 5 , , PUNCT bracis-33624 256 6 3rd 3rd ADJ bracis-33624 256 7 edn edn NOUN bracis-33624 256 8 , , PUNCT bracis-33624 256 9 pp pp ADJ bracis-33624 256 10 . . PUNCT bracis-33624 257 1 1–18 1–18 NOUN bracis-33624 257 2 . . PUNCT bracis-33624 258 1 academic academic ADJ bracis-33624 258 2 press press PROPN bracis-33624 258 3 , , PUNCT bracis-33624 258 4 boston boston PROPN bracis-33624 258 5 ( ( PUNCT bracis-33624 258 6 2017 2017 NUM bracis-33624 258 7 ) ) PUNCT bracis-33624 258 8 . . PUNCT bracis-33624 259 1 https://doi.org/10.1016/b978-0-12-800685-6.00001-1 https://doi.org/10.1016/b978-0-12-800685-6.00001-1 PROPN bracis-33624 259 2 katzeff katzeff PROPN bracis-33624 259 3 , , PUNCT bracis-33624 259 4 j.s j.s PROPN bracis-33624 259 5 . . PROPN bracis-33624 259 6 , , PUNCT bracis-33624 259 7 lok lok PROPN bracis-33624 259 8 , , PUNCT bracis-33624 259 9 h.c h.c PROPN bracis-33624 259 10 . . PROPN bracis-33624 259 11 , , PUNCT bracis-33624 259 12 bhatia bhatia PROPN bracis-33624 259 13 , , PUNCT bracis-33624 259 14 s. s. PROPN bracis-33624 259 15 , , PUNCT bracis-33624 259 16 fu fu PROPN bracis-33624 259 17 , , PUNCT bracis-33624 259 18 y. y. PROPN bracis-33624 259 19 , , PUNCT bracis-33624 259 20 halliday halliday PROPN bracis-33624 259 21 , , PUNCT bracis-33624 259 22 g.m g.m PROPN bracis-33624 259 23 . . PROPN bracis-33624 259 24 , , PUNCT bracis-33624 259 25 kim kim PROPN bracis-33624 259 26 , , PUNCT bracis-33624 259 27 w.s w.s PROPN bracis-33624 259 28 . . PROPN bracis-33624 259 29 : : PUNCT bracis-33624 259 30 atp atp NOUN bracis-33624 259 31 - - PUNCT bracis-33624 259 32 binding bind VERB bracis-33624 259 33 cassette cassette NOUN bracis-33624 259 34 transporter transporter NOUN bracis-33624 259 35 expression expression NOUN bracis-33624 259 36 is be AUX bracis-33624 259 37 widely widely ADV bracis-33624 259 38 dysregulated dysregulate VERB bracis-33624 259 39 in in ADP bracis-33624 259 40 frontotemporal frontotemporal ADJ bracis-33624 259 41 dementia dementia NOUN bracis-33624 259 42 with with ADP bracis-33624 259 43 tdp-43 tdp-43 NOUN bracis-33624 259 44 inclusions inclusion NOUN bracis-33624 259 45 ( ( PUNCT bracis-33624 259 46 2023 2023 NUM bracis-33624 259 47 ) ) PUNCT bracis-33624 259 48 . . PUNCT bracis-33624 260 1 https://doi.org/10.3389/fnmol.2022.1043127 https://doi.org/10.3389/fnmol.2022.1043127 PROPN bracis-33624 260 2 laksman laksman PROPN bracis-33624 260 3 , , PUNCT bracis-33624 260 4 z. z. PROPN bracis-33624 260 5 , , PUNCT bracis-33624 260 6 detsky detsky PROPN bracis-33624 260 7 , , PUNCT bracis-33624 260 8 a.s a.s PROPN bracis-33624 260 9 . . PROPN bracis-33624 260 10 : : PUNCT bracis-33624 260 11 personalized personalized ADJ bracis-33624 260 12 medicine medicine NOUN bracis-33624 260 13 : : PUNCT bracis-33624 260 14 understanding understand VERB bracis-33624 260 15 probabilities probability NOUN bracis-33624 260 16 and and CCONJ bracis-33624 260 17 managing managing NOUN bracis-33624 260 18 expectations expectation NOUN bracis-33624 260 19 . . PUNCT bracis-33624 261 1 j. j. PROPN bracis-33624 261 2 gen gen PROPN bracis-33624 261 3 . . PROPN bracis-33624 261 4 intern intern PROPN bracis-33624 261 5 . . PUNCT bracis-33624 262 1 med med PROPN bracis-33624 262 2 . . PROPN bracis-33624 263 1 26 26 NUM bracis-33624 263 2 , , PUNCT bracis-33624 263 3 204–206 204–206 NUM bracis-33624 263 4 ( ( PUNCT bracis-33624 263 5 2011 2011 NUM bracis-33624 263 6 ) ) PUNCT bracis-33624 263 7 . . PUNCT bracis-33624 264 1 https://doi.org/10.1007/s11606-010-1515-6 https://doi.org/10.1007/s11606-010-1515-6 PROPN bracis-33624 264 2 article article NOUN bracis-33624 264 3     SPACE bracis-33624 264 4 google google PROPN bracis-33624 264 5 scholar scholar NOUN bracis-33624 264 6     SPACE bracis-33624 264 7 li li PROPN bracis-33624 264 8 , , PUNCT bracis-33624 264 9 j. j. PROPN bracis-33624 264 10 , , PUNCT bracis-33624 264 11 et et PROPN bracis-33624 264 12 al al PROPN bracis-33624 264 13 . . PUNCT bracis-33624 264 14 : : PUNCT bracis-33624 265 1 genome genome NOUN bracis-33624 265 2 - - PUNCT bracis-33624 265 3 wide wide ADJ bracis-33624 265 4 network network NOUN bracis-33624 265 5 - - PUNCT bracis-33624 265 6 assisted assist VERB bracis-33624 265 7 association association NOUN bracis-33624 265 8 and and CCONJ bracis-33624 265 9 enrichment enrichment NOUN bracis-33624 265 10 study study NOUN bracis-33624 265 11 of of ADP bracis-33624 265 12 amyloid amyloid NOUN bracis-33624 265 13 imaging image VERB bracis-33624 265 14 phenotype phenotype NOUN bracis-33624 265 15 in in ADP bracis-33624 265 16 alzheimer alzheimer PROPN bracis-33624 265 17 ’s ’s PART bracis-33624 265 18 disease disease NOUN bracis-33624 265 19 . . PUNCT bracis-33624 266 1 curr curr PROPN bracis-33624 266 2 . . PUNCT bracis-33624 266 3 alzheimer alzheimer PROPN bracis-33624 266 4 res res PROPN bracis-33624 266 5 . . PUNCT bracis-33624 267 1 16 16 NUM bracis-33624 267 2 ( ( PUNCT bracis-33624 267 3 2019 2019 NUM bracis-33624 267 4 ) ) PUNCT bracis-33624 267 5 . . PUNCT bracis-33624 268 1 https://doi.org/10.2174/1567205016666191121142558 https://doi.org/10.2174/1567205016666191121142558 PUNCT bracis-33624 269 1 li li PROPN bracis-33624 269 2 , , PUNCT bracis-33624 269 3 r. r. PROPN bracis-33624 269 4 , , PUNCT bracis-33624 269 5 xiao xiao PROPN bracis-33624 269 6 , , PUNCT bracis-33624 269 7 l. l. PROPN bracis-33624 269 8 , , PUNCT bracis-33624 269 9 zhang zhang PROPN bracis-33624 269 10 , , PUNCT bracis-33624 269 11 t. t. PROPN bracis-33624 269 12 , , PUNCT bracis-33624 269 13 ren ren PROPN bracis-33624 269 14 , , PUNCT bracis-33624 269 15 d. d. PROPN bracis-33624 269 16 , , PUNCT bracis-33624 269 17 h h PROPN bracis-33624 269 18 , , PUNCT bracis-33624 269 19 z. z. PROPN bracis-33624 269 20 : : PUNCT bracis-33624 269 21 overexpression overexpression NOUN bracis-33624 269 22 of of ADP bracis-33624 269 23 fibroblast fibroblast ADJ bracis-33624 269 24 growth growth NOUN bracis-33624 269 25 factor factor NOUN bracis-33624 269 26 13 13 NUM bracis-33624 269 27 ameliorates ameliorate NOUN bracis-33624 269 28 amyloid amyloid NOUN bracis-33624 269 29 - - PUNCT bracis-33624 269 30 b b NOUN bracis-33624 269 31 - - PUNCT bracis-33624 269 32 induced induce VERB bracis-33624 269 33 neuronal neuronal ADJ bracis-33624 269 34 damage damage NOUN bracis-33624 269 35 . . PUNCT bracis-33624 270 1 neural neural ADJ bracis-33624 270 2 regeneration regeneration NOUN bracis-33624 270 3 research research NOUN bracis-33624 270 4 18 18 NUM bracis-33624 270 5 , , PUNCT bracis-33624 270 6 1347–1353 1347–1353 NUM bracis-33624 270 7 ( ( PUNCT bracis-33624 270 8 2023 2023 NUM bracis-33624 270 9 ) ) PUNCT bracis-33624 270 10 . . PUNCT bracis-33624 271 1 https://doi.org/10.4103/1673-5374.357902 https://doi.org/10.4103/1673-5374.357902 PROPN bracis-33624 272 1 mishra mishra PROPN bracis-33624 272 2 , , PUNCT bracis-33624 272 3 r. r. PROPN bracis-33624 272 4 , , PUNCT bracis-33624 272 5 et et PROPN bracis-33624 272 6 al al PROPN bracis-33624 272 7 . . PROPN bracis-33624 272 8 : : PUNCT bracis-33624 272 9 augmenting augment VERB bracis-33624 272 10 neurogenesis neurogenesis NOUN bracis-33624 272 11 rescues rescue NOUN bracis-33624 272 12 memory memory NOUN bracis-33624 272 13 impairments impairment NOUN bracis-33624 272 14 in in ADP bracis-33624 272 15 alzheimer alzheimer PROPN bracis-33624 272 16 ’s ’s PART bracis-33624 272 17 disease disease NOUN bracis-33624 272 18 by by ADP bracis-33624 272 19 restoring restore VERB bracis-33624 272 20 the the DET bracis-33624 272 21 memory memory NOUN bracis-33624 272 22 - - PUNCT bracis-33624 272 23 storing store VERB bracis-33624 272 24 neurons neuron NOUN bracis-33624 272 25 . . PUNCT bracis-33624 273 1 j. j. PROPN bracis-33624 273 2 exp exp PROPN bracis-33624 273 3 . . PROPN bracis-33624 273 4 med med PROPN bracis-33624 273 5 . . PUNCT bracis-33624 274 1 219 219 NUM bracis-33624 274 2 ( ( PUNCT bracis-33624 274 3 2022 2022 NUM bracis-33624 274 4 ) ) PUNCT bracis-33624 274 5 . . PUNCT bracis-33624 275 1 https://doi.org/10.1084/jem.20220391 https://doi.org/10.1084/jem.20220391 PROPN bracis-33624 275 2 moore moore PROPN bracis-33624 275 3 , , PUNCT bracis-33624 275 4 p.j p.j PROPN bracis-33624 275 5 . . PROPN bracis-33624 275 6 , , PUNCT bracis-33624 275 7 lyons lyons PROPN bracis-33624 275 8 , , PUNCT bracis-33624 275 9 t.j t.j PROPN bracis-33624 275 10 . . PROPN bracis-33624 275 11 , , PUNCT bracis-33624 275 12 gallacher gallacher PROPN bracis-33624 275 13 , , PUNCT bracis-33624 275 14 j. j. PROPN bracis-33624 275 15 , , PUNCT bracis-33624 275 16 initiative initiative NOUN bracis-33624 275 17 , , PUNCT bracis-33624 275 18 a.d.n a.d.n PROPN bracis-33624 275 19 . . PUNCT bracis-33624 275 20 : : PUNCT bracis-33624 275 21 random random ADJ bracis-33624 275 22 forest forest NOUN bracis-33624 275 23 prediction prediction NOUN bracis-33624 275 24 of of ADP bracis-33624 275 25 alzheimer alzheimer PROPN bracis-33624 275 26 ’s ’s PART bracis-33624 275 27 disease disease NOUN bracis-33624 275 28 using use VERB bracis-33624 275 29 pairwise pairwise NOUN bracis-33624 275 30 selection selection NOUN bracis-33624 275 31 from from ADP bracis-33624 275 32 time time NOUN bracis-33624 275 33 series series PROPN bracis-33624 275 34 data data PROPN bracis-33624 275 35 . . PUNCT bracis-33624 276 1 plos plos PROPN bracis-33624 276 2 one one NUM bracis-33624 276 3 14(2 14(2 NUM bracis-33624 276 4 ) ) PUNCT bracis-33624 276 5 , , PUNCT bracis-33624 276 6 e0211558 e0211558 PROPN bracis-33624 276 7 ( ( PUNCT bracis-33624 276 8 2019 2019 NUM bracis-33624 276 9 ) ) PUNCT bracis-33624 276 10 . . PUNCT bracis-33624 277 1 https://doi.org/10.1371/journal.pone.0211558 https://doi.org/10.1371/journal.pone.0211558 VERB bracis-33624 277 2 morabito morabito PROPN bracis-33624 277 3 , , PUNCT bracis-33624 277 4 s. s. PROPN bracis-33624 277 5 , , PUNCT bracis-33624 277 6 et et PROPN bracis-33624 277 7 al al PROPN bracis-33624 277 8 . . PROPN bracis-33624 277 9 : : PUNCT bracis-33624 278 1 single single ADJ bracis-33624 278 2 - - PUNCT bracis-33624 278 3 nucleus nucleus NOUN bracis-33624 278 4 chromatin chromatin NOUN bracis-33624 278 5 accessibility accessibility NOUN bracis-33624 278 6 and and CCONJ bracis-33624 278 7 transcriptomic transcriptomic ADJ bracis-33624 278 8 characterization characterization NOUN bracis-33624 278 9 of of ADP bracis-33624 278 10 alzheimer alzheimer PROPN bracis-33624 278 11 ’s ’s PART bracis-33624 278 12 disease disease NOUN bracis-33624 278 13 . . PUNCT bracis-33624 279 1 nat nat PROPN bracis-33624 279 2 . . PUNCT bracis-33624 280 1 genet genet NOUN bracis-33624 280 2 . . PUNCT bracis-33624 281 1 53 53 NUM bracis-33624 281 2 , , PUNCT bracis-33624 281 3 1–13 1–13 NOUN bracis-33624 281 4 ( ( PUNCT bracis-33624 281 5 2021 2021 NUM bracis-33624 281 6 ) ) PUNCT bracis-33624 281 7 . . PUNCT bracis-33624 282 1 https://doi.org/10.1038/s41588-021-00894-z https://doi.org/10.1038/s41588-021-00894-z PROPN bracis-33624 282 2 ou ou PROPN bracis-33624 282 3 , , PUNCT bracis-33624 282 4 y. y. PROPN bracis-33624 282 5 : : PUNCT bracis-33624 282 6 alzheimer alzheimer PROPN bracis-33624 282 7 ’s ’s PART bracis-33624 282 8 disease disease NOUN bracis-33624 282 9 and and CCONJ bracis-33624 282 10 glaucoma glaucoma NOUN bracis-33624 282 11 : : PUNCT bracis-33624 282 12 is be AUX bracis-33624 282 13 there there PRON bracis-33624 282 14 a a DET bracis-33624 282 15 connection connection NOUN bracis-33624 282 16 ? ? PUNCT bracis-33624 283 1 ( ( PUNCT bracis-33624 283 2 2017 2017 NUM bracis-33624 283 3 ) ) PUNCT bracis-33624 283 4 . . PUNCT bracis-33624 284 1 https://www.brightfocus.org/alzheimers/article/alzheimers-disease-and-glaucoma-there-connection https://www.brightfocus.org/alzheimers/article/alzheimers-disease-and-glaucoma-there-connection PROPN bracis-33624 284 2 . . PUNCT bracis-33624 285 1 accessed access VERB bracis-33624 285 2 30 30 NUM bracis-33624 285 3 june june PROPN bracis-33624 285 4 2024 2024 NUM bracis-33624 285 5 prince prince NOUN bracis-33624 285 6 , , PUNCT bracis-33624 285 7 m. m. NOUN bracis-33624 285 8 , , PUNCT bracis-33624 285 9 et et PROPN bracis-33624 285 10     SPACE bracis-33624 285 11 al al PROPN bracis-33624 285 12 . . PROPN bracis-33624 285 13 : : PUNCT bracis-33624 286 1 world world PROPN bracis-33624 286 2 alzheimer alzheimer PROPN bracis-33624 286 3 report report PROPN bracis-33624 286 4 2015 2015 NUM bracis-33624 286 5 ( ( PUNCT bracis-33624 286 6 2015 2015 NUM bracis-33624 286 7 ) ) PUNCT bracis-33624 286 8 . . PUNCT bracis-33624 287 1 https://www.alz.co.uk/research/worldalzheimerreport2015.pdf https://www.alz.co.uk/research/worldalzheimerreport2015.pdf PROPN bracis-33624 287 2 . . PUNCT bracis-33624 287 3 accessed access VERB bracis-33624 287 4 21 21 NUM bracis-33624 287 5 apr apr NOUN bracis-33624 287 6 2020 2020 NUM bracis-33624 287 7 pérez pérez NOUN bracis-33624 287 8 - - PUNCT bracis-33624 287 9 torres torre NOUN bracis-33624 287 10 , , PUNCT bracis-33624 287 11 s. s. PROPN bracis-33624 287 12 , , PUNCT bracis-33624 287 13 mengod mengod PROPN bracis-33624 287 14 , , PUNCT bracis-33624 287 15 g. g. NOUN bracis-33624 287 16 : : PUNCT bracis-33624 287 17 camp camp NOUN bracis-33624 287 18 - - PUNCT bracis-33624 287 19 specific specific ADJ bracis-33624 287 20 phosphodiesterases phosphodiesterase NOUN bracis-33624 287 21 expression expression NOUN bracis-33624 287 22 in in ADP bracis-33624 287 23 alzheimer alzheimer PROPN bracis-33624 287 24 ’s ’s PART bracis-33624 287 25 disease disease NOUN bracis-33624 287 26 brains brain NOUN bracis-33624 287 27 . . PUNCT bracis-33624 288 1 int int NOUN bracis-33624 288 2 . . PUNCT bracis-33624 289 1 congr congr PROPN bracis-33624 289 2 . . PUNCT bracis-33624 290 1 ser ser PROPN bracis-33624 290 2 . . PROPN bracis-33624 290 3 1251 1251 NUM bracis-33624 290 4 , , PUNCT bracis-33624 290 5 127–138 127–138 NUM bracis-33624 290 6 ( ( PUNCT bracis-33624 290 7 2003 2003 NUM bracis-33624 290 8 ) ) PUNCT bracis-33624 290 9 . . PUNCT bracis-33624 291 1 https://doi.org/10.1016/s0531-5131(03)00104-3 https://doi.org/10.1016/s0531-5131(03)00104-3 PROPN bracis-33624 291 2 article article NOUN bracis-33624 291 3     SPACE bracis-33624 291 4 google google PROPN bracis-33624 291 5 scholar scholar NOUN bracis-33624 291 6     SPACE bracis-33624 291 7 recabarren recabarren NOUN bracis-33624 291 8 , , PUNCT bracis-33624 291 9 d. d. PROPN bracis-33624 291 10 , , PUNCT bracis-33624 291 11 alarcón alarcón PROPN bracis-33624 291 12 , , PUNCT bracis-33624 291 13 m. m. NOUN bracis-33624 291 14 : : PUNCT bracis-33624 291 15 gene gene NOUN bracis-33624 291 16 networks network NOUN bracis-33624 291 17 in in ADP bracis-33624 291 18 neurodegenerative neurodegenerative ADJ bracis-33624 291 19 disorders disorder NOUN bracis-33624 291 20 . . PUNCT bracis-33624 292 1 life life NOUN bracis-33624 292 2 sciences science NOUN bracis-33624 292 3 183 183 NUM bracis-33624 292 4 ( ( PUNCT bracis-33624 292 5 2017 2017 NUM bracis-33624 292 6 ) ) PUNCT bracis-33624 292 7 . . PUNCT bracis-33624 293 1 https://doi.org/10.1016/j.lfs.2017.06.009 https://doi.org/10.1016/j.lfs.2017.06.009 PROPN bracis-33624 293 2 sepulveda sepulveda PROPN bracis-33624 293 3 - - PUNCT bracis-33624 293 4 falla falla PROPN bracis-33624 293 5 , , PUNCT bracis-33624 293 6 d. d. PROPN bracis-33624 293 7 , , PUNCT bracis-33624 293 8 et et PROPN bracis-33624 293 9 al al PROPN bracis-33624 293 10 . . PUNCT bracis-33624 293 11 : : PUNCT bracis-33624 294 1 genetic genetic ADJ bracis-33624 294 2 modifiers modifier NOUN bracis-33624 294 3 of of ADP bracis-33624 294 4 cognitive cognitive ADJ bracis-33624 294 5 decline decline NOUN bracis-33624 294 6 in in ADP bracis-33624 294 7 psen1 psen1 ADJ bracis-33624 294 8 e280a e280a PROPN bracis-33624 294 9 alzheimer alzheimer PROPN bracis-33624 294 10 ’s ’s PART bracis-33624 294 11 disease disease NOUN bracis-33624 294 12 . . PUNCT bracis-33624 295 1 alzheimer alzheimer PROPN bracis-33624 295 2 ’s ’s PART bracis-33624 295 3 dementia dementia NOUN bracis-33624 295 4 20 20 NUM bracis-33624 295 5 ( ( PUNCT bracis-33624 295 6 2024 2024 NUM bracis-33624 295 7 ) ) PUNCT bracis-33624 295 8 . . PUNCT bracis-33624 296 1 https://doi.org/10.1002/alz.13754 https://doi.org/10.1002/alz.13754 PROPN bracis-33624 296 2 sereniki sereniki PROPN bracis-33624 296 3 , , PUNCT bracis-33624 296 4 a. a. NOUN bracis-33624 296 5 , , PUNCT bracis-33624 296 6 vital vital ADJ bracis-33624 296 7 , , PUNCT bracis-33624 296 8 m.a.b.f m.a.b.f PROPN bracis-33624 296 9 . . PROPN bracis-33624 296 10 : : PUNCT bracis-33624 296 11 a a DET bracis-33624 296 12 doença doença NOUN bracis-33624 296 13 de de X bracis-33624 296 14 alzheimer alzheimer PROPN bracis-33624 296 15 : : PUNCT bracis-33624 296 16 aspectos aspectos PROPN bracis-33624 296 17 fisiopatológicos fisiopatológicos PROPN bracis-33624 296 18 e e PROPN bracis-33624 296 19 farmacológicos farmacológicos PROPN bracis-33624 296 20 . . PUNCT bracis-33624 297 1 revista revista PROPN bracis-33624 297 2 de de PROPN bracis-33624 297 3 psiquiatria psiquiatria PROPN bracis-33624 297 4 do do AUX bracis-33624 297 5 rio rio PROPN bracis-33624 297 6 grande grande PROPN bracis-33624 297 7 do do VERB bracis-33624 297 8 sul sul PROPN bracis-33624 297 9 30 30 NUM bracis-33624 297 10 ( ( PUNCT bracis-33624 297 11 2008 2008 NUM bracis-33624 297 12 ) ) PUNCT bracis-33624 297 13 . . PUNCT bracis-33624 298 1 https://doi.org/10.1590/s0101-81082008000200002 https://doi.org/10.1590/s0101-81082008000200002 PROPN bracis-33624 298 2 sherif sherif PROPN bracis-33624 298 3 , , PUNCT bracis-33624 298 4 f. f. PROPN bracis-33624 298 5 , , PUNCT bracis-33624 298 6 zayed zayed PROPN bracis-33624 298 7 , , PUNCT bracis-33624 298 8 n. n. NOUN bracis-33624 298 9 , , PUNCT bracis-33624 298 10 fakhr fakhr NOUN bracis-33624 298 11 , , PUNCT bracis-33624 298 12 m. m. NOUN bracis-33624 298 13 : : PUNCT bracis-33624 298 14 discovering discover VERB bracis-33624 298 15 alzheimer alzheimer ADJ bracis-33624 298 16 genetic genetic ADJ bracis-33624 298 17 biomarkers biomarker NOUN bracis-33624 298 18 using use VERB bracis-33624 298 19 bayesian bayesian NOUN bracis-33624 298 20 networks network NOUN bracis-33624 298 21 . . PUNCT bracis-33624 299 1 adv adv PROPN bracis-33624 299 2 . . PUNCT bracis-33624 299 3 bioinform bioinform PROPN bracis-33624 299 4 . . PUNCT bracis-33624 300 1 2015 2015 NUM bracis-33624 300 2 , , PUNCT bracis-33624 300 3 639367 639367 NUM bracis-33624 300 4 ( ( PUNCT bracis-33624 300 5 2015 2015 NUM bracis-33624 300 6 ) ) PUNCT bracis-33624 300 7 . . PUNCT bracis-33624 301 1 https://doi.org/10.1155/2015/639367 https://doi.org/10.1155/2015/639367 PROPN bracis-33624 301 2 spiegel spiegel PROPN bracis-33624 301 3 , , PUNCT bracis-33624 301 4 a.m. a.m. ADV bracis-33624 301 5 , , PUNCT bracis-33624 301 6 hawkins hawkins PROPN bracis-33624 301 7 , , PUNCT bracis-33624 301 8 m. m. NOUN bracis-33624 301 9 : : PUNCT bracis-33624 301 10 personalized personalized ADJ bracis-33624 301 11 medicine medicine NOUN bracis-33624 301 12 to to PART bracis-33624 301 13 identify identify VERB bracis-33624 301 14 genetic genetic ADJ bracis-33624 301 15 risks risk NOUN bracis-33624 301 16 for for ADP bracis-33624 301 17 type type NOUN bracis-33624 301 18 2 2 NUM bracis-33624 301 19 diabetes diabetes NOUN bracis-33624 301 20 and and CCONJ bracis-33624 301 21 focus focus VERB bracis-33624 301 22 prevention prevention NOUN bracis-33624 301 23 : : PUNCT bracis-33624 301 24 can can AUX bracis-33624 301 25 it it PRON bracis-33624 301 26 fulfill fulfill VERB bracis-33624 301 27 its its PRON bracis-33624 301 28 promise promise NOUN bracis-33624 301 29 ? ? PUNCT bracis-33624 302 1 health health NOUN bracis-33624 302 2 aff aff PROPN bracis-33624 302 3 . . PUNCT bracis-33624 303 1 31(1 31(1 NUM bracis-33624 303 2 ) ) PUNCT bracis-33624 303 3 , , PUNCT bracis-33624 303 4 43–51 43–51 NUM bracis-33624 303 5 ( ( PUNCT bracis-33624 303 6 2012 2012 NUM bracis-33624 303 7 ) ) PUNCT bracis-33624 303 8 . . PUNCT bracis-33624 304 1 https://doi.org/10.1377/hlthaff.2011.1054 https://doi.org/10.1377/hlthaff.2011.1054 PROPN bracis-33624 304 2 article article NOUN bracis-33624 304 3     SPACE bracis-33624 304 4 math math NOUN bracis-33624 304 5     SPACE bracis-33624 304 6 google google PROPN bracis-33624 304 7 scholar scholar NOUN bracis-33624 304 8     SPACE bracis-33624 304 9 velazquez velazquez PROPN bracis-33624 304 10 , , PUNCT bracis-33624 304 11 m. m. NOUN bracis-33624 304 12 , , PUNCT bracis-33624 304 13 lee lee PROPN bracis-33624 304 14 , , PUNCT bracis-33624 304 15 y. y. PROPN bracis-33624 304 16 for for ADP bracis-33624 304 17 the the DET bracis-33624 304 18 alzheimer alzheimer PROPN bracis-33624 304 19 ’s ’s PART bracis-33624 304 20 disease disease NOUN bracis-33624 304 21 neuroimaging neuroimaging NOUN bracis-33624 304 22 initiative initiative NOUN bracis-33624 304 23 : : PUNCT bracis-33624 304 24 random random ADJ bracis-33624 304 25 forest forest NOUN bracis-33624 304 26 model model NOUN bracis-33624 304 27 for for ADP bracis-33624 304 28 feature feature NOUN bracis-33624 304 29 - - PUNCT bracis-33624 304 30 based base VERB bracis-33624 304 31 alzheimer alzheimer PROPN bracis-33624 304 32 ’s ’s PART bracis-33624 304 33 disease disease NOUN bracis-33624 304 34 conversion conversion NOUN bracis-33624 304 35 prediction prediction NOUN bracis-33624 304 36 from from ADP bracis-33624 304 37 early early ADJ bracis-33624 304 38 mild mild ADJ bracis-33624 304 39 cognitive cognitive ADJ bracis-33624 304 40 impairment impairment NOUN bracis-33624 304 41 subjects subject NOUN bracis-33624 304 42 . . PUNCT bracis-33624 305 1 plos plos PROPN bracis-33624 305 2 one one NUM bracis-33624 305 3 16(4 16(4 NUM bracis-33624 305 4 ) ) PUNCT bracis-33624 305 5 , , PUNCT bracis-33624 305 6 1–18 1–18 PROPN bracis-33624 305 7 ( ( PUNCT bracis-33624 305 8 2021 2021 NUM bracis-33624 305 9 ) ) PUNCT bracis-33624 305 10 . . PUNCT bracis-33624 306 1 https://doi.org/10.1371/journal.pone.0244773 https://doi.org/10.1371/journal.pone.0244773 PROPN bracis-33624 306 2 wiggs wiggs PROPN bracis-33624 306 3 , , PUNCT bracis-33624 306 4 j. j. PROPN bracis-33624 306 5 , , PUNCT bracis-33624 306 6 et et PROPN bracis-33624 306 7 al al PROPN bracis-33624 306 8 . . PUNCT bracis-33624 306 9 : : PUNCT bracis-33624 307 1 common common ADJ bracis-33624 307 2 variants variant NOUN bracis-33624 307 3 at at ADP bracis-33624 307 4 9p21 9p21 NOUN bracis-33624 307 5 and and CCONJ bracis-33624 307 6 8q22 8q22 NUM bracis-33624 307 7 are be AUX bracis-33624 307 8 associated associate VERB bracis-33624 307 9 with with ADP bracis-33624 307 10 increased increase VERB bracis-33624 307 11 susceptibility susceptibility NOUN bracis-33624 307 12 to to ADP bracis-33624 307 13 optic optic VERB bracis-33624 307 14 nerve nerve NOUN bracis-33624 307 15 degeneration degeneration NOUN bracis-33624 307 16 in in ADP bracis-33624 307 17 glaucoma glaucoma NOUN bracis-33624 307 18 . . PUNCT bracis-33624 308 1 plos plos PROPN bracis-33624 308 2 genet genet PROPN bracis-33624 308 3 . . PUNCT bracis-33624 309 1 8 8 NUM bracis-33624 309 2 , , PUNCT bracis-33624 309 3 e1002654 e1002654 ADJ bracis-33624 309 4 ( ( PUNCT bracis-33624 309 5 2012 2012 NUM bracis-33624 309 6 ) ) PUNCT bracis-33624 309 7 . . PUNCT bracis-33624 310 1 https://doi.org/10.1371/journal.pgen.1002654 https://doi.org/10.1371/journal.pgen.1002654 PROPN bracis-33624 310 2 wu wu PROPN bracis-33624 310 3 , , PUNCT bracis-33624 310 4 z. z. PROPN bracis-33624 310 5 , , PUNCT bracis-33624 310 6 et et PROPN bracis-33624 310 7 al al PROPN bracis-33624 310 8 . . PUNCT bracis-33624 310 9 : : PUNCT bracis-33624 311 1 a a DET bracis-33624 311 2 novel novel ADJ bracis-33624 311 3 alzheimer alzheimer PROPN bracis-33624 311 4 ’s ’s PART bracis-33624 311 5 disease disease PROPN bracis-33624 311 6 prognostic prognostic ADJ bracis-33624 311 7 signature signature NOUN bracis-33624 311 8 : : PUNCT bracis-33624 311 9 identification identification NOUN bracis-33624 311 10 and and CCONJ bracis-33624 311 11 analysis analysis NOUN bracis-33624 311 12 of of ADP bracis-33624 311 13 glutamine glutamine NOUN bracis-33624 311 14 metabolism metabolism NOUN bracis-33624 311 15 genes gene NOUN bracis-33624 311 16 in in ADP bracis-33624 311 17 immunogenicity immunogenicity NOUN bracis-33624 311 18 and and CCONJ bracis-33624 311 19 immunotherapy immunotherapy NOUN bracis-33624 311 20 efficacy efficacy NOUN bracis-33624 311 21 . . PUNCT bracis-33624 312 1 sci sci PROPN bracis-33624 312 2 . . PROPN bracis-33624 312 3 rep rep PROPN bracis-33624 312 4 . . PROPN bracis-33624 312 5 13 13 NUM bracis-33624 312 6 ( ( PUNCT bracis-33624 312 7 2023 2023 NUM bracis-33624 312 8 ) ) PUNCT bracis-33624 312 9 . . PUNCT bracis-33624 313 1 https://doi.org/10.1038/s41598-023-33277-x https://doi.org/10.1038/s41598-023-33277-x PROPN bracis-33624 313 2 yu yu PROPN bracis-33624 313 3 , , PUNCT bracis-33624 313 4 w. w. PROPN bracis-33624 313 5 , , PUNCT bracis-33624 313 6 yu yu PROPN bracis-33624 313 7 , , PUNCT bracis-33624 313 8 w. w. PROPN bracis-33624 313 9 , , PUNCT bracis-33624 313 10 yang yang PROPN bracis-33624 313 11 , , PUNCT bracis-33624 313 12 y. y. PROPN bracis-33624 313 13 , , PUNCT bracis-33624 313 14 lü lü PROPN bracis-33624 313 15 , , PUNCT bracis-33624 313 16 y. y. NOUN bracis-33624 313 17 : : PUNCT bracis-33624 313 18 exploring explore VERB bracis-33624 313 19 the the DET bracis-33624 313 20 key key ADJ bracis-33624 313 21 genes gene NOUN bracis-33624 313 22 and and CCONJ bracis-33624 313 23 identification identification NOUN bracis-33624 313 24 of of ADP bracis-33624 313 25 potential potential ADJ bracis-33624 313 26 diagnosis diagnosis NOUN bracis-33624 313 27 biomarkers biomarker NOUN bracis-33624 313 28 in in ADP bracis-33624 313 29 alzheimer alzheimer PROPN bracis-33624 313 30 ’s ’s PART bracis-33624 313 31 disease disease NOUN bracis-33624 313 32 using use VERB bracis-33624 313 33 bioinformatics bioinformatics NOUN bracis-33624 313 34 analysis analysis NOUN bracis-33624 313 35 . . PUNCT bracis-33624 314 1 front front NOUN bracis-33624 314 2 . . PUNCT bracis-33624 315 1 aging age VERB bracis-33624 315 2 neurosci neurosci NOUN bracis-33624 315 3 . . PUNCT bracis-33624 316 1 13 13 NUM bracis-33624 316 2 , , PUNCT bracis-33624 316 3 602781 602781 NUM bracis-33624 316 4 ( ( PUNCT bracis-33624 316 5 2021 2021 NUM bracis-33624 316 6 ) ) PUNCT bracis-33624 316 7 . . PUNCT bracis-33624 317 1 https://doi.org/10.3389/fnagi.2021.602781 https://doi.org/10.3389/fnagi.2021.602781 PROPN bracis-33624 317 2 article article NOUN bracis-33624 317 3     SPACE bracis-33624 317 4 math math NOUN bracis-33624 317 5     SPACE bracis-33624 317 6 google google PROPN bracis-33624 317 7 scholar scholar NOUN bracis-33624 317 8     SPACE bracis-33624 317 9 zhu zhu PROPN bracis-33624 317 10 , , PUNCT bracis-33624 317 11 m. m. NOUN bracis-33624 317 12 , , PUNCT bracis-33624 317 13 tang tang PROPN bracis-33624 317 14 , , PUNCT bracis-33624 317 15 m. m. NOUN bracis-33624 317 16 , , PUNCT bracis-33624 317 17 du du PROPN bracis-33624 317 18 , , PUNCT bracis-33624 317 19 y. y. NOUN bracis-33624 317 20 : : PUNCT bracis-33624 317 21 identification identification NOUN bracis-33624 317 22 of of ADP bracis-33624 317 23 tac1 tac1 NOUN bracis-33624 317 24 associated associate VERB bracis-33624 317 25 with with ADP bracis-33624 317 26 alzheimer alzheimer PROPN bracis-33624 317 27 ’s ’s PART bracis-33624 317 28 disease disease NOUN bracis-33624 317 29 using use VERB bracis-33624 317 30 a a DET bracis-33624 317 31 robust robust ADJ bracis-33624 317 32 rank rank NOUN bracis-33624 317 33 aggregation aggregation NOUN bracis-33624 317 34 approach approach NOUN bracis-33624 317 35 . . PUNCT bracis-33624 318 1 j. j. PROPN bracis-33624 318 2 alzheimers alzheimers PROPN bracis-33624 318 3 dis dis PROPN bracis-33624 318 4 . . PROPN bracis-33624 319 1 91 91 NUM bracis-33624 319 2 , , PUNCT bracis-33624 319 3 1–11 1–11 PROPN bracis-33624 319 4 ( ( PUNCT bracis-33624 319 5 2023 2023 NUM bracis-33624 319 6 ) ) PUNCT bracis-33624 319 7 . . PUNCT bracis-33624 320 1 https://doi.org/10.3233/jad-220950 https://doi.org/10.3233/jad-220950 PROPN bracis-33624 320 2 article article NOUN bracis-33624 320 3     SPACE bracis-33624 320 4 math math NOUN bracis-33624 320 5     SPACE bracis-33624 320 6 google google PROPN bracis-33624 320 7 scholar scholar NOUN bracis-33624 320 8     SPACE bracis-33624 320 9 download download NOUN bracis-33624 320 10 references reference NOUN bracis-33624 320 11 acknowledgment acknowledgment NOUN bracis-33624 320 12 this this DET bracis-33624 320 13 study study NOUN bracis-33624 320 14 was be AUX bracis-33624 320 15 financed finance VERB bracis-33624 320 16 by by ADP bracis-33624 320 17 the the DET bracis-33624 320 18 são são PROPN bracis-33624 320 19 paulo paulo PROPN bracis-33624 320 20 research research PROPN bracis-33624 320 21 foundation foundation PROPN bracis-33624 320 22 ( ( PUNCT bracis-33624 320 23 fapesp fapesp NOUN bracis-33624 320 24 ) ) PUNCT bracis-33624 320 25 grants grant VERB bracis-33624 320 26 # # SYM bracis-33624 320 27 2020/08634 2020/08634 NUM bracis-33624 320 28 - - SYM bracis-33624 320 29 2 2 NUM bracis-33624 320 30 , , PUNCT bracis-33624 320 31 # # SYM bracis-33624 320 32 2021/12618 2021/12618 NUM bracis-33624 320 33 - - SYM bracis-33624 320 34 5 5 NUM bracis-33624 320 35 and and CCONJ bracis-33624 320 36 # # SYM bracis-33624 320 37 2022/02981 2022/02981 NUM bracis-33624 320 38 - - SYM bracis-33624 320 39 8 8 NUM bracis-33624 320 40 . . PUNCT bracis-33624 321 1 author author NOUN bracis-33624 321 2 information information NOUN bracis-33624 321 3 authors author NOUN bracis-33624 321 4 and and CCONJ bracis-33624 321 5 affiliations affiliation NOUN bracis-33624 321 6 department department PROPN bracis-33624 321 7 of of ADP bracis-33624 321 8 computing computing PROPN bracis-33624 321 9 , , PUNCT bracis-33624 321 10 federal federal ADJ bracis-33624 321 11 university university PROPN bracis-33624 321 12 of of ADP bracis-33624 321 13 são são PROPN bracis-33624 321 14 carlos carlos PROPN bracis-33624 321 15 , , PUNCT bracis-33624 321 16 são são PROPN bracis-33624 321 17 carlos carlos PROPN bracis-33624 321 18 , , PUNCT bracis-33624 321 19 sp sp PROPN bracis-33624 321 20 , , PUNCT bracis-33624 321 21 brazil brazil PROPN bracis-33624 321 22 juliana juliana PROPN bracis-33624 321 23 alves alves PROPN bracis-33624 321 24 corteva corteva PROPN bracis-33624 321 25 agriscience agriscience PROPN bracis-33624 321 26 ™ ™ PROPN bracis-33624 321 27 , , PUNCT bracis-33624 321 28 mogi mogi PROPN bracis-33624 321 29 mirim mirim PROPN bracis-33624 321 30 , , PUNCT bracis-33624 321 31 sp sp PROPN bracis-33624 321 32 , , PUNCT bracis-33624 321 33 brazil brazil PROPN bracis-33624 321 34 eduardo eduardo PROPN bracis-33624 321 35 costa costa PROPN bracis-33624 321 36     SPACE bracis-33624 321 37 & & CCONJ bracis-33624 321 38     SPACE bracis-33624 321 39 alencar alencar PROPN bracis-33624 321 40 xavier xavier PROPN bracis-33624 321 41 department department PROPN bracis-33624 321 42 of of ADP bracis-33624 321 43 animal animal NOUN bracis-33624 321 44 sciences sciences PROPN bracis-33624 321 45 , , PUNCT bracis-33624 321 46 purdue purdue ADJ bracis-33624 321 47 university university NOUN bracis-33624 321 48 , , PUNCT bracis-33624 321 49 west west PROPN bracis-33624 321 50 lafayette lafayette PROPN bracis-33624 321 51 , , PUNCT bracis-33624 321 52 in in ADP bracis-33624 321 53 , , PUNCT bracis-33624 321 54 usa usa PROPN bracis-33624 321 55 alencar alencar PROPN bracis-33624 321 56 xavier xavier PROPN bracis-33624 321 57     SPACE bracis-33624 321 58 & & CCONJ bracis-33624 321 59     SPACE bracis-33624 321 60 luiz luiz PROPN bracis-33624 321 61 brito brito PROPN bracis-33624 321 62 institute institute PROPN bracis-33624 321 63 of of ADP bracis-33624 321 64 mathematics mathematics PROPN bracis-33624 321 65 and and CCONJ bracis-33624 321 66 computer computer NOUN bracis-33624 321 67 science science NOUN bracis-33624 321 68 , , PUNCT bracis-33624 321 69 university university PROPN bracis-33624 321 70 of of ADP bracis-33624 321 71 são são PROPN bracis-33624 321 72 paulo paulo PROPN bracis-33624 321 73 , , PUNCT bracis-33624 321 74 são são PROPN bracis-33624 321 75 carlos carlos PROPN bracis-33624 321 76 , , PUNCT bracis-33624 321 77 sp sp PROPN bracis-33624 321 78 , , PUNCT bracis-33624 321 79 brazil brazil PROPN bracis-33624 321 80 ricardo ricardo PROPN bracis-33624 321 81 cerri cerri PROPN bracis-33624 321 82 authors author NOUN bracis-33624 321 83 juliana juliana PROPN bracis-33624 321 84 alvesview alvesview VERB bracis-33624 321 85 author author NOUN bracis-33624 321 86 publications publication NOUN bracis-33624 321 87 search search NOUN bracis-33624 321 88 author author NOUN bracis-33624 321 89 on on ADP bracis-33624 321 90 : : PUNCT bracis-33624 321 91 pubmed pubmed PROPN bracis-33624 321 92     SPACE bracis-33624 321 93 google google PROPN bracis-33624 321 94 scholar scholar PROPN bracis-33624 321 95 eduardo eduardo PROPN bracis-33624 321 96 costaview costaview PROPN bracis-33624 321 97 author author NOUN bracis-33624 321 98 publications publication NOUN bracis-33624 321 99 search search NOUN bracis-33624 321 100 author author NOUN bracis-33624 321 101 on on ADP bracis-33624 321 102 : : PUNCT bracis-33624 321 103 pubmed pubmed PROPN bracis-33624 321 104     SPACE bracis-33624 321 105 google google PROPN bracis-33624 321 106 scholar scholar PROPN bracis-33624 321 107 alencar alencar PROPN bracis-33624 321 108 xavierview xavierview PROPN bracis-33624 321 109 author author NOUN bracis-33624 321 110 publications publication VERB bracis-33624 321 111 search search NOUN bracis-33624 321 112 author author NOUN bracis-33624 321 113 on on ADP bracis-33624 321 114 : : PUNCT bracis-33624 321 115 pubmed pubmed PROPN bracis-33624 321 116     SPACE bracis-33624 321 117 google google PROPN bracis-33624 321 118 scholar scholar NOUN bracis-33624 321 119 luiz luiz NOUN bracis-33624 321 120 britoview britoview NOUN bracis-33624 321 121 author author NOUN bracis-33624 321 122 publications publication NOUN bracis-33624 321 123 search search NOUN bracis-33624 321 124 author author NOUN bracis-33624 321 125 on on ADP bracis-33624 321 126 : : PUNCT bracis-33624 321 127 pubmed pubmed PROPN bracis-33624 321 128     SPACE bracis-33624 321 129 google google PROPN bracis-33624 321 130 scholar scholar NOUN bracis-33624 321 131 ricardo ricardo PROPN bracis-33624 321 132 cerriview cerriview NOUN bracis-33624 321 133 author author NOUN bracis-33624 321 134 publications publication NOUN bracis-33624 321 135 search search NOUN bracis-33624 321 136 author author NOUN bracis-33624 321 137 on on ADP bracis-33624 321 138 : : PUNCT bracis-33624 321 139 pubmed pubmed PROPN bracis-33624 321 140     SPACE bracis-33624 321 141 google google PROPN bracis-33624 321 142 scholar scholar NOUN bracis-33624 321 143 consortia consortia PROPN bracis-33624 321 144 alzheimer alzheimer PROPN bracis-33624 321 145 ’s ’s PART bracis-33624 321 146 disease disease NOUN bracis-33624 321 147 neuroimaging neuroimaging NOUN bracis-33624 321 148 initiative initiative NOUN bracis-33624 321 149 corresponding correspond VERB bracis-33624 321 150 authors author NOUN bracis-33624 321 151 correspondence correspondence NOUN bracis-33624 321 152 to to ADP bracis-33624 321 153 juliana juliana PROPN bracis-33624 321 154 alves alves PROPN bracis-33624 321 155 or or CCONJ bracis-33624 321 156 ricardo ricardo PROPN bracis-33624 321 157 cerri cerri PROPN bracis-33624 321 158 . . PUNCT bracis-33624 322 1 editor editor NOUN bracis-33624 322 2 information information NOUN bracis-33624 322 3 editors editor NOUN bracis-33624 322 4 and and CCONJ bracis-33624 322 5 affiliations affiliation NOUN bracis-33624 322 6 universidade universidade VERB bracis-33624 322 7 federal federal PROPN bracis-33624 322 8 fluminense fluminense PROPN bracis-33624 322 9 , , PUNCT bracis-33624 322 10 niterói niterói PROPN bracis-33624 322 11 , , PUNCT bracis-33624 322 12 brazil brazil PROPN bracis-33624 322 13 aline aline PROPN bracis-33624 322 14 paes paes PROPN bracis-33624 322 15 instituto instituto PROPN bracis-33624 322 16 tecnológico tecnológico PROPN bracis-33624 322 17 de de PROPN bracis-33624 322 18 aeronáutica aeronáutica PROPN bracis-33624 322 19 , , PUNCT bracis-33624 322 20 são são PROPN bracis-33624 322 21 josé josé PROPN bracis-33624 322 22 dos dos PROPN bracis-33624 322 23 campos campos PROPN bracis-33624 322 24 , , PUNCT bracis-33624 322 25 brazil brazil PROPN bracis-33624 322 26 filipe filipe PROPN bracis-33624 322 27 a. a. PROPN bracis-33624 322 28 n. n. PROPN bracis-33624 322 29 verri verri PROPN bracis-33624 322 30 rights right NOUN bracis-33624 322 31 and and CCONJ bracis-33624 322 32 permissions permission NOUN bracis-33624 322 33 reprints reprint NOUN bracis-33624 322 34 and and CCONJ bracis-33624 322 35 permissions permission VERB bracis-33624 322 36 copyright copyright NOUN bracis-33624 322 37 information information NOUN bracis-33624 322 38 © © ADP bracis-33624 322 39 2025 2025 NUM bracis-33624 322 40 the the DET bracis-33624 322 41 author(s author(s NOUN bracis-33624 322 42 ) ) PUNCT bracis-33624 322 43 , , PUNCT bracis-33624 322 44 under under ADP bracis-33624 322 45 exclusive exclusive ADJ bracis-33624 322 46 license license NOUN bracis-33624 322 47 to to ADP bracis-33624 322 48 springer springer NOUN bracis-33624 322 49 nature nature PROPN bracis-33624 322 50 switzerland switzerland PROPN bracis-33624 322 51 ag ag PROPN bracis-33624 322 52 about about ADP bracis-33624 322 53 this this DET bracis-33624 322 54 paper paper NOUN bracis-33624 322 55 cite cite VERB bracis-33624 322 56 this this DET bracis-33624 322 57 paper paper NOUN bracis-33624 322 58 alves alve NOUN bracis-33624 322 59 , , PUNCT bracis-33624 322 60 j. j. PROPN bracis-33624 322 61 , , PUNCT bracis-33624 322 62 costa costa PROPN bracis-33624 322 63 , , PUNCT bracis-33624 322 64 e. e. PROPN bracis-33624 322 65 , , PUNCT bracis-33624 322 66 xavier xavier PROPN bracis-33624 322 67 , , PUNCT bracis-33624 322 68 a. a. PROPN bracis-33624 322 69 , , PUNCT bracis-33624 322 70 brito brito PROPN bracis-33624 322 71 , , PUNCT bracis-33624 322 72 l. l. PROPN bracis-33624 322 73 , , PUNCT bracis-33624 322 74 cerri cerri PROPN bracis-33624 322 75 , , PUNCT bracis-33624 322 76 r. r. PROPN bracis-33624 322 77 , , PUNCT bracis-33624 322 78 alzheimer alzheimer PROPN bracis-33624 322 79 ’s ’s PART bracis-33624 322 80 disease disease NOUN bracis-33624 322 81 neuroimaging neuroimaging NOUN bracis-33624 322 82 initiative initiative NOUN bracis-33624 322 83 . . PUNCT bracis-33624 323 1 ( ( PUNCT bracis-33624 323 2 2025 2025 NUM bracis-33624 323 3 ) ) PUNCT bracis-33624 323 4 . . PUNCT bracis-33624 324 1 comparative comparative ADJ bracis-33624 324 2 analysis analysis NOUN bracis-33624 324 3 of of ADP bracis-33624 324 4     SPACE bracis-33624 324 5 machine machine NOUN bracis-33624 324 6 learning learn VERB bracis-33624 324 7 algorithms algorithm NOUN bracis-33624 324 8 for for ADP bracis-33624 324 9     SPACE bracis-33624 324 10 identifying identify VERB bracis-33624 324 11 genetic genetic ADJ bracis-33624 324 12 markers marker NOUN bracis-33624 324 13 linked link VERB bracis-33624 324 14 to to ADP bracis-33624 324 15     SPACE bracis-33624 324 16 alzheimer alzheimer PROPN bracis-33624 324 17 ’s ’s PART bracis-33624 324 18 disease disease NOUN bracis-33624 324 19 . . PUNCT bracis-33624 325 1 in in ADP bracis-33624 325 2 : : PUNCT bracis-33624 325 3 paes paes PROPN bracis-33624 325 4 , , PUNCT bracis-33624 325 5 a. a. PROPN bracis-33624 325 6 , , PUNCT bracis-33624 325 7 verri verri NOUN bracis-33624 325 8 , , PUNCT bracis-33624 325 9 f.a.n f.a.n ADJ bracis-33624 325 10 . . PUNCT bracis-33624 325 11 ( ( PUNCT bracis-33624 325 12 eds ed NOUN bracis-33624 325 13 ) ) PUNCT bracis-33624 325 14 intelligent intelligent ADJ bracis-33624 325 15 systems system NOUN bracis-33624 325 16 . . PUNCT bracis-33624 325 17 bracis bracis PROPN bracis-33624 325 18 2024 2024 NUM bracis-33624 325 19 . . PUNCT bracis-33624 326 1 lecture lecture NOUN bracis-33624 326 2 notes note NOUN bracis-33624 326 3 in in ADP bracis-33624 326 4 computer computer NOUN bracis-33624 326 5 science science NOUN bracis-33624 326 6 ( ( PUNCT bracis-33624 326 7 ) ) PUNCT bracis-33624 326 8 , , PUNCT bracis-33624 326 9 vol vol NOUN bracis-33624 326 10 15414 15414 NUM bracis-33624 326 11 . . PUNCT bracis-33624 327 1 springer springer NOUN bracis-33624 327 2 , , PUNCT bracis-33624 327 3 cham cham PROPN bracis-33624 327 4 . . PUNCT bracis-33624 328 1 https://doi.org/10.1007/978-3-031-79035-5_11 https://doi.org/10.1007/978-3-031-79035-5_11 NUM bracis-33624 328 2 download download NOUN bracis-33624 328 3 citation citation NOUN bracis-33624 328 4 .ris .ris PUNCT bracis-33624 328 5 .enw .enw PROPN bracis-33624 328 6 .bib .bib PUNCT bracis-33624 329 1 doi doi PROPN bracis-33624 329 2 : : PUNCT bracis-33624 330 1 https://doi.org/10.1007/978-3-031-79035-5_11 https://doi.org/10.1007/978-3-031-79035-5_11 PROPN bracis-33624 330 2 published publish VERB bracis-33624 330 3 : : PUNCT bracis-33624 330 4 30 30 NUM bracis-33624 330 5 january january PROPN bracis-33624 330 6 2025 2025 NUM bracis-33624 330 7 publisher publisher NOUN bracis-33624 330 8 name name NOUN bracis-33624 330 9 : : PUNCT bracis-33624 330 10 springer springer NOUN bracis-33624 330 11 , , PUNCT bracis-33624 330 12 cham cham PROPN bracis-33624 330 13 print print PROPN bracis-33624 330 14 isbn isbn PROPN bracis-33624 330 15 : : PUNCT bracis-33624 330 16 978 978 NUM bracis-33624 330 17 - - SYM bracis-33624 330 18 3 3 NUM bracis-33624 330 19 - - PUNCT bracis-33624 330 20 031 031 NUM bracis-33624 330 21 - - PUNCT bracis-33624 330 22 79034 79034 NUM bracis-33624 330 23 - - SYM bracis-33624 330 24 8 8 NUM bracis-33624 330 25 online online ADJ bracis-33624 330 26 isbn isbn NOUN bracis-33624 330 27 : : PUNCT bracis-33624 330 28 978 978 NUM bracis-33624 330 29 - - SYM bracis-33624 330 30 3 3 NUM bracis-33624 330 31 - - PUNCT bracis-33624 330 32 031 031 NUM bracis-33624 330 33 - - PUNCT bracis-33624 330 34 79035 79035 NUM bracis-33624 330 35 - - PUNCT bracis-33624 330 36 5 5 NUM bracis-33624 330 37 ebook ebook NOUN bracis-33624 330 38 packages package NOUN bracis-33624 330 39 : : PUNCT bracis-33624 330 40 computer computer NOUN bracis-33624 330 41 sciencecomputer sciencecomputer NOUN bracis-33624 330 42 science science NOUN bracis-33624 330 43 ( ( PUNCT bracis-33624 330 44 r0 r0 NOUN bracis-33624 330 45 ) ) PUNCT bracis-33624 330 46 share share VERB bracis-33624 330 47 this this DET bracis-33624 330 48 paper paper NOUN bracis-33624 330 49 anyone anyone PRON bracis-33624 330 50 you you PRON bracis-33624 330 51 share share VERB bracis-33624 330 52 the the DET bracis-33624 330 53 following follow VERB bracis-33624 330 54 link link NOUN bracis-33624 330 55 with with ADP bracis-33624 330 56 will will AUX bracis-33624 330 57 be be AUX bracis-33624 330 58 able able ADJ bracis-33624 330 59 to to PART bracis-33624 330 60 read read VERB bracis-33624 330 61 this this DET bracis-33624 330 62 content content NOUN bracis-33624 330 63 : : PUNCT bracis-33624 330 64 get get VERB bracis-33624 330 65 shareable shareable ADJ bracis-33624 330 66 linksorry linksorry NOUN bracis-33624 330 67 , , PUNCT bracis-33624 330 68 a a DET bracis-33624 330 69 shareable shareable ADJ bracis-33624 330 70 link link NOUN bracis-33624 330 71 is be AUX bracis-33624 330 72 not not PART bracis-33624 330 73 currently currently ADV bracis-33624 330 74 available available ADJ bracis-33624 330 75 for for ADP bracis-33624 330 76 this this DET bracis-33624 330 77 article article NOUN bracis-33624 330 78 . . PUNCT bracis-33624 331 1 copy copy VERB bracis-33624 331 2 shareable shareable ADJ bracis-33624 331 3 link link NOUN bracis-33624 331 4 to to PART bracis-33624 331 5 clipboard clipboard NOUN bracis-33624 331 6 provided provide VERB bracis-33624 331 7 by by ADP bracis-33624 331 8 the the DET bracis-33624 331 9 springer springer NOUN bracis-33624 331 10 nature nature PROPN bracis-33624 331 11 sharedit sharedit PROPN bracis-33624 331 12 content content NOUN bracis-33624 331 13 - - PUNCT bracis-33624 331 14 sharing share VERB bracis-33624 331 15 initiative initiative NOUN bracis-33624 331 16 keywords keyword NOUN bracis-33624 331 17 alzheimer alzheimer PROPN bracis-33624 331 18 ’s ’s PART bracis-33624 331 19 disease disease NOUN bracis-33624 331 20 gwas gwas NOUN bracis-33624 331 21 disease disease NOUN bracis-33624 331 22 prediction prediction NOUN bracis-33624 331 23 genetic genetic ADJ bracis-33624 331 24 markers marker NOUN bracis-33624 331 25 single single ADJ bracis-33624 331 26 nucleotide nucleotide NOUN bracis-33624 331 27 polymorphisms polymorphism NOUN bracis-33624 331 28 ( ( PUNCT bracis-33624 331 29 snps snps NOUN bracis-33624 331 30 ) ) PUNCT bracis-33624 331 31 machine machine NOUN bracis-33624 331 32 learning learning NOUN bracis-33624 331 33 publish publish VERB bracis-33624 331 34 with with ADP bracis-33624 331 35 us us PROPN bracis-33624 331 36 policies policy NOUN bracis-33624 331 37 and and CCONJ bracis-33624 331 38 ethics ethic NOUN bracis-33624 331 39 profiles profile NOUN bracis-33624 331 40 eduardo eduardo PROPN bracis-33624 331 41 costa costa PROPN bracis-33624 331 42 view view PROPN bracis-33624 331 43 author author NOUN bracis-33624 331 44 profile profile PROPN bracis-33624 331 45 luiz luiz PROPN bracis-33624 331 46 brito brito PROPN bracis-33624 331 47 view view PROPN bracis-33624 331 48 author author NOUN bracis-33624 331 49 profile profile PROPN bracis-33624 331 50 ricardo ricardo PROPN bracis-33624 331 51 cerri cerri PROPN bracis-33624 331 52 view view PROPN bracis-33624 331 53 author author NOUN bracis-33624 331 54 profile profile NOUN bracis-33624 331 55 search search NOUN bracis-33624 331 56 search search NOUN bracis-33624 331 57 by by ADP bracis-33624 331 58 keyword keyword NOUN bracis-33624 331 59 or or CCONJ bracis-33624 331 60 author author NOUN bracis-33624 331 61 search search NOUN bracis-33624 331 62 navigation navigation NOUN bracis-33624 331 63 find find VERB bracis-33624 331 64 a a DET bracis-33624 331 65 journal journal NOUN bracis-33624 331 66 publish publish VERB bracis-33624 331 67 with with ADP bracis-33624 331 68 us we PRON bracis-33624 331 69 track track VERB bracis-33624 331 70 your your PRON bracis-33624 331 71 research research NOUN bracis-33624 331 72 discover discover VERB bracis-33624 331 73 content content NOUN bracis-33624 331 74 journals journal NOUN bracis-33624 331 75 a a DET bracis-33624 331 76 - 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