id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
anesthj-92	Gray, Lauren	Prevention of Opioid Induced Hyperalgesia Following Remifentanil Infusion: A Case Report	2022	4	.pdf	application/pdf	2389	141	46	It is postulated that OIH is due to central sensitization through activation of NMDA receptors.3 In support of this hypothesis, the NMDA receptor antagonist ketamine has been shown to decrease postoperative pain intensity and morphine requirements in patients receiving remifentanil infusion during general anesthesia.4,5 Hong and colleagues used a 0.3-mg/kg intravenous bolus of ketamine during induction followed by a 3-mcg/kg/min ketamine infusion during surgery to effectively prevent OIH and decrease the total amount of opioids required in those undergoing general anesthesia utilizing sevoflurane and remifentanil.4 A separate study set out to determine the effective dose of ketamine to prevent OIH. These techniques include intravenous ketamine, inhaled nitrous oxide, oral pregabalin, and gradual cessation of remifentanil infusion.	cache/anesthj-92.pdf	txt/anesthj-92.txt