1 © 2025 Conscientia Beam. All Rights Reserved. A brief overview of the impact of avian influenza on animals John T. Hancock1+ Ros C. Rouse2 Gareth Robinson3 Tim J. Craig4 1,3,4School of Applied Sciences, University of the West of England, Bristol, BS16 1QY, UK. 1Email: John.hancock@uwe.ac.uk 3Email: Gareth2.robinson@uwe.ac.uk 4Email: Tim.craig@uwe.ac.uk 2Business and Innovation, University of the West of England, Bristol BS16 1QY, UK. 2Email: Ros.rouse@uwe.ac.uk (+ Corresponding author) ABSTRACT Article History Received: 14 November 2024 Revised: 30 December 2024 Accepted: 10 January 2025 Published: 27 January 2025 Keywords Animal-human transmission Avian influenza Bird flu Cattle H5N1 Marine mammals Mink. Avian influenza (AI) virus, and the (HPAI)H5N1 subtype in particular, is a serious problem for many wild bird populations, where devastating losses have been reported. However, AI is not restricted to bird species. Here, a literature search was used to assess the range of animals infected by AI. This included reports in the scientific journals as well as news outlets. As can be seen, infection has been reported in commercial mammals such as cattle and mink where there is close animal-to-animal contact, as well as close contact with humans. Some domestic animals, such as cats, have been reported to be AI virus positive too, again where there is a possibility that conditions will be conducive to animal-to- human transmission. Many animals in the wild have been found to be infected with AI virus, and many of these, perhaps not surprisingly, are marine mammals. Mink-to-mink viral transmission has been suggested to have taken place, but most animals which have been infected have had close contact with birds, often handling or eating carcasses. There are also reports of humans becoming infected, for example, from cattle. Although this overview is intended to be neither comprehensive nor quantitative it is hoped that such information will aid in the management of AI, especially (HPAI)H5N1, in the future. Contribution/Originality: This article gives an up-to-date overview of the range of animals which have been reported to be infection-positive for Avian influenza. This shows that the viral infection is not restricted to birds, but is found in many mammalian species. 1. INTRODUCTION Avian influenza (AI) virus has been in circulation for many years. Originally referred to as “Fowl Plague” it was first described in northern Italy in 1878, and about twenty years later was found to be caused by a virus, which was further characterized in 1955 as a type A influenza virus [1]. Avian influenza (AI: often known as avian flu or bird flu) virus, especially the (HPAI)H5N1 subtype (clade 2.3.4.4b), is one of these. AI has led to devastating drops in bird populations, especially sea birds, such as reported by the BBC in February 2024 [2]. AI is caused by a virus which has two main types: Highly pathogenicity avian influenza [HPAI] and low pathogenicity avian influenza (LPAI) [3]. These groups are subdivided into haemagglutinin [H1–H16] and neuraminidase [N1–N9] subtypes. Most LPAI viruses cause a milder form of disease. HPAI viruses have H5 and H7 subtypes, and many of these subtypes have been found in infected birds. Probably the subtype of most Animal Review 2025 Vol. 12, No. 1, pp. 1-16. ISSN(e): 2409-6490 ISSN(p): 2412-3382 DOI: 10.18488/92.v12i1.4051 © 2025 Conscientia Beam. All Rights Reserved. mailto:John.hancock@uwe.ac.uk mailto:Gareth2.robinson@uwe.ac.uk mailto:Tim.craig@uwe.ac.uk mailto:Ros.rouse@uwe.ac.uk https://www.doi.org/10.18488/92.v12i1.4051 Animal Review, 2025, 12(1): 1-16 2 © 2025 Conscientia Beam. All Rights Reserved. concern is (HPAI)H5N1. Much has been written about bird outbreaks and possible bird infections, both in the scientific literature [4-6] and the popular media [2, 7-9] so this will not be considered in depth here. What is perhaps less well known is the evidence that AI viruses can infect a wide range of mammals, with differing symptoms. The fact that humans can become infected with the AI viruses is well-established, but remains of concern, and there is some discussion about H5N1 becoming the next pandemic subtype [10-12]. A recent British Broadcasting Corporation (BBC) article asks if the AI pandemic is inching towards humans [13]. Although there are other reviews covering this topic, such as that by Peacock, et al. [14] and others Consortium, et al. [15]; Graziosi, et al. [16] and Plaza, et al. [17] it seems timely to bring some examples of non-avian species being reported as infected with the AI virus together. Here a broad approach for a review is used, encompassing reports from science literature, but also more common media outlets such as news channels, as often these are looked at in isolation and by a wide range of readers. This is not a comprehensive report, but a brief overview to get an overall picture of what the present situation is like, and to highlight literature where a more in-depth discussion can be found if required. 2. MATERIALS AND METHODS To obtain information for this overview a wide range of sources were used. These included reports found on the internet, and media outputs, such as Guardian newspaper (UK) and the BBC. Sci-entific literature was also sourced, primarily from Google Scholar [18] or National Library of Medicine Pubmed [19] and the original articles accessed and cited. 3. EVIDENCE OF A WIDE RANGE OF ANIMAL SPECIES BEING INFECTED WITH AI There is certainly concern about where the next human viral pandemic will emerge from. SARS-Cov-2, which caused the COVID-19 pandemic, was thought to originate from bats, and the transmission to humans has been hotly debated, for example in work by Ridley and Brown [20] and the exact route will probably never be known. However, others have asked what we might consider as the next emergent zoonotic disease [21] and AI is a candidate. In experimental animal models it has been clearly shown that some non-avian species can be infected with AI. H5N1 (HPAI) can cause upper respiratory tract infection in ferrets and cats [22] and ferrets have been used in cytokine studies Short, et al. [23]. Rhesus macaques have also been used, again for studying cytokine effects caused by AI [24]. Guinea pigs have been used for assessing the public health risk [25]. Belser [26] gave an update on the use of animal models, albeit back in 2009 [26] which included a discussion of the use of mice. Of course, more current reviews on the use of animals in influenza research are also available [e.g. Nguyen, et al. [27]]. With the media reporting that several animals are now being infected by AI virus, it is timely to look at this more deeply. In April 2024 the Guardian reported the first case of AI in a walrus [28] along with a wide range of birds, including penguins [29]. Here, we have looked across the literature and pulled out examples which highlight the widespread nature of AI virus. It clearly is not just found in avian species, as can be seen in Table 1. Animal Review, 2025, 12(1): 1-16 3 © 2025 Conscientia Beam. All Rights Reserved. Table 1. Examples of animals (Including humans) being reported positive for avian influenza vi-rus. Data was gathered until mid-August 2024. Animal group Animal type Animal(s) Country Cause (If known) Subtype (If known) Ref. Notes Birds Commercial Poultry: Broiler chickens, turkeys USA - A(H7N3) USDA [30] 11 flocks, 8.8 M birds Poultry Russia - A(H5N8) Pyankova, et al. [31] - Turkeys USA - HPAI H5N1 CDC [32] - Poultry India - H5N1 World Organization for Animal Health [33] - Birds Wild Goose, duck, sanderling, eagle, crow, bufflehead, owl, cormorant, hawk, raven, vulture, ruddy turnstone, blackbird, pigeon, grackle, teal, pintail, swan, gull USA - - USDA [34] - Penguins South Georgia - - BBC News [29] - Mute swans (Cygnus olor) Denmark - H5N1 World Organization for Animal Health (WOAH) [35] Swans were dead Various (Non-poultry including wild birds) Denmark - H5N8 World Organization for Animal Health [36] - Various (Non-poultry including wild birds) Canada - H5N5 World Organization for Animal Health [37] - Great skuas UK - H5N1 Guardian [38] 75% decline in population Gannets UK - H5N1 Guardian [38] 25% decline in population Black-headed gulls, guillemots, kittiwakes, herring gulls, terns UK - - RSPB [39] - Cranes Hungary - - RSPB [39] Large outbreaks Swans Romania - - RSPB [39] Large outbreaks Black-headed gulls UK - - British Trust for Ornithology [40] 10000 (4% UK population: 2023) Terns UK - - British Trust for Ornithology [40] - Birds Domestic 8 cases in birds Timor-Leste - H5N1 World Organization for Animal Health [41] - Animal Review, 2025, 12(1): 1-16 4 © 2025 Conscientia Beam. All Rights Reserved. Mammal Commercial Dairy cows USA - HPAI H5N1 CDC [32] First cows reported (Kansas and Texas (March 2024) Cows (Cattle) USA - USDA [42] Across at least 10 states Mink Spain From wild waterfowl? HPAI H5N1 CDC [32] May have been mink- mink transmission Mink Sweden - LPAI H10N4 CDC [32] 1984 (October) Mink USA From people (?) A(H1N1) CDC [32] 2019 Goats USA - H5N1 World Organization for Animal Health [43] 2024 (March) Foxes, mink, raccoon dogs Finland Not confirmed - UK Health Security Agency [44] Near bird oubreak Big cat, lion, bobcat, bear, fox, coyote, fisher (Pekania pennanti), marten, otter, racoon, skunk, opossum, squirrel USA - Includes H5N1 USDA [45] - Seal, fox UK - HPAI H5N8 CDC [32] - Foxes, bears, skunks Canada - H5N1 CDC [32] - Mammal Wild Fox Netherlands From birds? HPAI H5N1 BBC News [29] 2021 Fox Estonia - - CDC [32] - Fox, otter, lynx, badger Europe - HPAI H5 CDC [32] - Raccoon dogs, foxes Japan - HPAI H5 CDC [32] - Polar bear Arctic - HPAI A(H5N1) CDC [32] Animal died/first report from arctic animal (2023: December) Red fox Sweden - H5N1 World Organization for Animal Health [46] 2023 (August) Animal Review, 2025, 12(1): 1-16 5 © 2025 Conscientia Beam. All Rights Reserved. Red fox Northern Ireland - HPAI H5N1 World Organization for Animal Health [47] 2023 (August) Red fox Scotland - H5N1 World Organization for Animal Health [47] - Cats Poland - H5N1 World Organization for Animal Health [48] - Cats France, Italy - H5N1 UK Health Security Agency [44] - Lion (Panthera leo) Peru - H5N1 World Organization for Animal Health [48] - Mammal Domestic Cat Thailand Ate pigeon carcass (HPAI) H5N1 Songserm, et al. [49] - Cat Germany From wild birds? H5N1 Klopfleisch, et al. [50] - Cat South Korea Migratory birds that travelled from Japan and South Korea? - CIDRAP [51] - Dogs Italy On poultry farm - UK Health Security Agency [44] 5 dogs infected Bush dog UK Contaminat- ed meat? H5N1 CIDRAP [51] - Bottle nose dolphin, seal, USA - - USDA [45] - Walrus Hopen Island (Svalbard) - - The Guardian [28] First such case April 2024 Sea lions Peru - HPAI H5N1 CDC [32] - Mammal Marine Sea lions New England - H5N1 CDC [32] - Seals UK, Germany, Denmark - H7N7, H4N5, H4N6, H3N3, H10N7 CDC [32] 2021 Seals USA - HPAI H5N1 CDC [32] 10 animals Animal Review, 2025, 12(1): 1-16 6 © 2025 Conscientia Beam. All Rights Reserved. Elephant seal, fur seal, South polar region - HPAI A(H5N1) CDC [32] First from south polar region: 2023 (December) Grey seal, porpoise, dolphin UK - HPAI H5N1 (H5Nx) World Organization for Animal Health [47] 2023(March) Southern elephant seals (Mirounga leonina)/ 1 Antarctic fur seal (Arctocephalus gazella). South Georgia Island - H5N1 World Organization for Animal Health [47] - Seal lion (Otaria flavescens)- and dolphin (Tursiops truncatus) Peru - H5N1 World Organization for Animal Health [48] - Harbor seals (Phoca vitulina) Denmark Possibly from dead swans HPAI H5N1 World Organization for Animal Health (WOAH) [35] - Spiny porpoise (Phocoena spinipinnis) and Chilean dolphin (Cephalorhynchus eutropia). Chile - H5N1 World Organization for Animal Health [48] - Mammal Human 2 cases USA From poultry (2022), one from cattle (2024) - CDC [52] - 1 case Russia Poultry farmer- (December 2020) A(H5N8) Pyankova, et al. [31] - Child with moderate illness Hong Kong Poultry (?) (2020) LPAI H9N2 CDC [32] - Child with mild illness Senegal Poultry (2019) LPAI H9N2 CDC [32] - Five cases China - LPAI H9N2 CDC [32] - Asymptomatic 80-year-old man England Ducks HPAI H5N1 CDC [32] - China - LPAI H3N8 CDC [32] 2022 (April) Seven cases China Poultry HPAI H5N6 CDC [32] 2022 Four cases China - LPAI H9N2 CDC [32] - Young child Cambodia - LPAI H9N2 CDC [32] - Animal Review, 2025, 12(1): 1-16 7 © 2025 Conscientia Beam. All Rights Reserved. Child Vietnam Poultry HPAI A(H5) CDC [32] - Four cases (Three children) China - LPAI H9N2 CDC [32] 2022 One case (died) China Poultry HPAI H5N1 CDC [32] 2022 Child Laos Poultry HPAI H5N6 CDC [32] 2021 One case (Died) China Poultry? LPAI H10N3 CDC [32] 2021 (May) 36 cases China - HPAI H5N6 CDC [32] During 2021 - 18 deaths 24 cases China - LPAI H9N2 CDC [32] One death Four cases China Poultry HPAI H5N6 CDC [32] May-Sept 2022 - one death One case China Not known LPAI H10N3 CDC [32] 2022(May) Four cases China - LPAI H9N2 CDC [32] One hospitalised Two cases (Asymptomatic) Spain Poultry workers HPAI H5N1 CDC [32] 2022 One case (Child) Ecuador Poultry HPAI A(H5) CDC [32] 2023 (January) Two cases (Asymptomatic) Cambodia - HPAI H5N1 CDC [32] One death One case USA - HPAI) A(H5N1 CDC [32] First case of cow-human transmission One case USA - H5N1 Looi [53] Farmer from cattle: State of Michigan Animal Review, 2025, 12(1): 1-16 8 © 2025 Conscientia Beam. All Rights Reserved. There are some general points which can be highlighted from the data. Firstly, it is obviously a global problem. In the UK, there are reports of major problems in birds in Scotland and Wales, for example, as reported by the BBC News [54] although on 30th May 2024 the UK government declared the country free of bird flu [55]. However, reports of animal infections span across USA, Russia, Japan, India, Thailand, South Korea etc. There are even reports from the polar regions, with elephant seals and fur seals being infected in the south [32] and polar bears being infected in the Arctic [32]. Secondly, there is a growing range of animals which are becoming infected. One of the groups which has reached prominence in the press is cattle [42]. This has been quite widespread, especially in the USA and it has been reported across at least ten States and 85 herds. Other commercial animals include goats [56] but perhaps more notably mink [32, 57]. Here worries may arise because of potential parallels with the prominence of mink infections during the COVID-19 pandemic [58]. During COVID-19, millions of mink in several countries were killed as they were found to be infected with SARS-CoV-2, mink-mink transmission was reported, and then perhaps more alarmingly there were suggestions of mink-human infection routes [59]. It has been thought that mink-mink AI viral transmission has already happened [32] as well as a farmer suspected of becoming infected from cattle [13]. A second case of a farmer being infected from a herd of cows was recently been reported [53] whilst in July 2024 it was reported that there were four dairy workers who had tested positive [60]. Infected cows may pass on the virus in their milk. The situation with AI virus and cattle was recently reviewed by Neumann and Kawaoka [61]. In USA, it has been reported that 24 cats contracted H5N1 on a single farm, and this was thought to be down to consumption of raw milk [62]. Half of these animals died. Cats more generally have been raised as a concern, with reports that in the USA at least 16 have contracted AI virus this year [63] presumably from eating infected wild birds. As well as commercial animals which may be in contact with other animals, such as birds, but also in the close vicinity of humans, wild animals have been found to be infected. It is likely that these animals are becoming infected as they are in contact with, perhaps eating, infected carcasses. If a bird is frail because it is suffering, or if it had already died, then it becomes an easy target for other animals, many which are known to scavenge. Perhaps it should come as no surprise that foxes, bears, and coyotes are listed. Other species include lion, skunk, and otter. Domestic animals are being reported as being infected, especially cats [62, 63] and these may have become infected by eating carcasses, for example, one was reported as eating a dead pigeon, even though it would be assumed that such animals are well fed in their domestic environment. Cats were particularly infected with SARS-CoV-2 [64, 65] and although drawing parallels between the two diseases is fraught with issues due to the profound differences in the causative viruses, it is still quite concerning that companion animals are so susceptible to AI virus. Indeed, AI infection in cats is not trivial. In Poland, 47 cats were tested (including one Caracal caracal), with 29 being positive from 13 regions of the country. Cats had a range of symptoms, including bloody diarrhea, breathing problems and neurological issues. Eleven cats died [66]. And as stated above 16 were found to be positive in the USA this year [63]. Of prominence in the list given here are marine mammals (Table 1), no doubt because of their proximity to seabirds such as tern and gulls. Seals and walruses have already been mentioned here, but also listed are dolphins and porpoises. The reports are quite worldwide too, ranging from the UK and Denmark to USA, and then down to Peru, Chile, and the polar regions. What can be seen from the results are several points worth noting. It is worldwide, it is not just avian species which have found to be infected, and, so far, contact with infected birds is often, but not always, the cause. Animal Review, 2025, 12(1): 1-16 9 © 2025 Conscientia Beam. All Rights Reserved. 4. DISCUSSION Birds have been the focus in discussions of AI spread and prevalent, although not all birds have the same morbidity [67, 68]. This is not the first time the matter of AI viral infection has been dis-cussed outside of bird species [69-71] and it is unlikely to be the last. Others are collating similar data, also on a global scale. One excellent source of data is from the Food and Agriculture Organization of the United Nations, which under a section on Animal Health, lists animals infected with H5Nx HPAI [72]. There are numerous bird species listed, as would be expected. These range across farmed animals including chickens, ducks, emu, and ostrich, as well as a wide range of wild birds. These include water birds such as ducks and geese, but also owls, hawks, robins, crows, and woodpeckers. Mammalian species which have been reported to be infected include a similar range of animals to that listed above, but also include wild boars, pika, and badgers. What is also telling about this list is that any new species identified as being positive since 2021 are written in red, and a glance at the list suggests about half of all the listings are so colored. This is an indication that either the viruses are spreading to more species quite dramatically, or that surveillance has significantly improved, or a combination of both. One of the issues which is worth considering is of course why the virus has the ability to infect the cells of certain animals and not others. The molecular biology of the infection of cells with the AI virus is not covered here, but others have reviewed the area. For example, Wang, et al. [11] consider the epidemiology, virology and pathogenicity of human infections, with the view to gaining a better understanding of interspecies transmission of the virus. Charostad, et al. [73] discuss the structural biology and genetics of H5N1, and then go on to look at the immune response to the virus in humans. The apparent prevalence of the AI virus across a range of mammalian species leads to some suggesting that we should at least raise awareness [74] with the BMJ asking if we should be worried “about a growing threat from “bird flu””, for example [75]. Therefore, it seems a timely point to bring some of the reports on how AI is affecting mammalian species into one place, and to discuss the range of what is happening around the world. This is particularly important as conservation work continues, and people interact with the natural environment, and animals within it, in a variety of ways [76]. Of importance here are the ramifications for human health. As highlighted in Table 1, humans around the world have been reported to be AI virus positive. Many of these so far are from China, Cambodia, Vietnam, Hong Kong and Laos, although there are other examples from USA, Spain, UK and Ecuador. Perhaps of particular concern is the suggestion that AI virus infected farmers who had close contact with their diseased cows [13, 53]. Therefore, there is no reason why any area of the world is safe and not likely to see future infections in humans. Such infections are often because people are in close contact with birds, usually poultry, which is an understandable route to become infected. Recently, the first death of a person with the H5N2 subtype of the virus was reported [74, 77]. This is far from a comprehensive review of the situation, but does highlight the breadth of the issue. Vaccines for AI are available, although in the UK it is stated that poultry and most captive birds must not be vaccinated, with zoo birds being able to be inoculated if they meet specific criteria [44]. What is unclear at this stage is how vaccination of animals involved in the food chain might be deemed appropriate, given it prevents serious disease rather than infection, thus might prove a risk within the food chain. This short review may enable researchers, academics, and students to reflect on their activities. If walking along a beach and seeing a few dead gannets, is it appropriate to use them as a research sample or elements of them in an artwork [76]? Afterall, the European Centre for Disease Prevention and Control (ECDC) gives, “the general recommendation to not touch any sick or dead animals.” [71]. They go on to say “There is no single vaccine against avian influenza. A specific vaccine is needed for each specific avian influenza strain,” [as of Feb 2023]. Similar advice was given by the UK Health Security Agency, who advised that: “Members of the public should be discouraged from touching dead or sick animals.” [44]. In twenty-three years leading up to 2019, 881 infections of Animal Review, 2025, 12(1): 1-16 10 © 2025 Conscientia Beam. All Rights Reserved. H5N1 were reported in humans, with a case fatality rate (CFR) rate of 52%, so this can be a serious disease. Of course, this is not the only review to suggest pandemic preparedness for AI [78] (and of course there is a general pandemic preparedness context [79]) but here are few there are things which could be done for the future. These may include: • Better education of those who may come into contact with AI, especially if that contact may not be expected, such as on fieldtrips or simply being in the natural environment, or a farm setting. Worryingly, some people are seeking raw milk infected with H5N1, thinking that it will boost their immunity [80] so clearly correct dissemination of information is important; • Further vigilance and surveying of the global situation. This is taking place by several oganizations such as the CDC, but raw data needs to be fed into such databases; • Further research into the animal-to-animal transmission of AI virus, and animal-to-human infection, as well as potentially human-to-animal infection with the virus; • Can the susceptibility of animals to AI be predicted [78] and why do some animals get infected and not others [81]? This may give an idea of which species need to be targeted for surveillance and intervention, and as importantly, to know which animals can be ignored. Such attempts at predictions for the susceptibility to the SARS-CoV-2 virus appeared to have limited success, and several surprises were seen [59] but this should not prevent similar work being carried out with the AI virus; • The consequences of the infection of specific animals need to be addressed in detail; not just from an economic or social point of view, but in the context of both human and animal disease control. Which animals are more likely to pass the disease on to humans? And which animals are likely to be infected by humans? Which animals (including humans) are likely to suffer more severe symptoms from the different subtypes? Might some animals act as a means of transmission of the virus? Might this be a source of a more contagious and/or virulent subtype, potentially with mammal to mammal and/or human-to-human transmission? Certainly, there is evidence that, for some viruses at least, infection of specific animal populations may enhance the viral mutation rate, making the emergence of such a dangerous subtype more likely [59]. Interestingly, it has been reported that the bovine HPAI H5N1 virus may have features which facilitates its infection and also transmission in mammals [82]. • What preparatory action should be taken in terms of the development and production (ultmately at scale, and of a vaccine for the specific subtype(s) necessary at the time, so not stockpiled) of AI virus vaccines, and a planned roll-out if required? • How will the complexities of animal vaccination be navigated, both in relation to wild animals (including at risk populations), animals involved in the food chain (for meat, or eggs, for example), as well as pets. What will ‘animal welfare’ mean here for animals denied a vaccine, or subject to culling? How will this play out in terms of human need and human equity (such equity not being a feature of the SARS-CoV-2 pandemic) versus animal need? Will some animals be given vaccines before some humans (assuming that vaccine supply will be limited), and will this be on the basis of their perceived utility (such as farm animals, or endangered/valued species), or on the basis of their role and importance in disease transmission? If vaccination is not found to be effective in pre-venting disease but only decreasing symptomatic response, what will this mean for animals – based on the SARS-CoV-2 pandemic (and prior examples in the UK such a TB in cattle and badgers) the response may be one of culling, not vaccination. How will the response be affected by the relative severity of symptoms of the prevalent subtypes in a pandemic for humans and animals? These issues may fundamentally affect the ‘landscape’ for animals in the future, as well as the welfare of individual animals. Animal Review, 2025, 12(1): 1-16 11 © 2025 Conscientia Beam. All Rights Reserved. • What might be the impact on global food security? If vaccination is not ‘the answer’ (as some infected animals may pass into the food chain) then what impacts might there be on the availability of animal-based food material, and what specific enhanced biosecurity measures might be needed, at what cost, and to whom? • In what ways should we be concerned about domestic animals, which after all, will have close contact with humans, so could infect, or be infected by, their humans. Cats have been shown to be susceptible to infection with AI virus (and high morbidity and mortality), for example (also seen with SARS-CoV-2); It is to be remembered that in the early stages of the COVID-19 pandemic, the UK Government did consider a cull of domestic cats [59]. • If an HPAI pandemic does arrive, with a subtype which has a high death rate for humans (say of the order of 50 percent), then what will be the impacts on animal welfare more broadly. We know during the COVID-19 pandemic that panic meant some animals were targeted [59] so it is not unreasonable to assume that pet abandonment, and the killing of ‘suspected’ wildlife, might also feature in human responses across the globe. 5. CONCLUSIONS It is clear that Avian influenza viral infections are not restricted to birds and that several of the subtypes can cause infection in a wide range of mammal species, including humans. No reptiles, amphibians or fish have been found to be infected, but marine mammals are known to be AI virus positive. At the time of writing, one of the animals of most concern is cattle, partly as they are in the human food chain and also as they are in close contact with humans. Farmers have been reported to be infected, but to date no deaths of humans have been reported from this transmission route, with this subtype. As with other zoonotic viruses, such as SARS-CoV-2, mutations are likely to take place in infected animals, and this will make it more likely that a wider range of vertebrate species could be infected, and it makes it more likely that a subtype will develop with the potential for human infection, and human to human transmission, and potentially high human morbidity and mortality, with potential for epidemic/pandemic. It is hoped that this article will highlight some of the interesting emergent information about the global position with AI virus and animals, even though it is not intended to be a comprehensive review. Hopefully, the global pandemic preparedness initiatives will fully consider animal health, welfare and conservation aspects of AI infection. It is also to be hoped that current and future monitoring and vigilance, research and effective and timely mitigations will stop the spread and mutation of AI virus becoming the next human pandemic, with all the attendant animal and human welfare issues. Funding: This study received no specific financial support. Institutional Review Board Statement: Not applicable. Transparency: The authors declare that the manuscript is honest, truthful and transparent, that no important aspects of the study have been omitted and that all deviations from the planned study have been made clear. This study followed all rules of writing ethics. Competing Interests: The authors declare that they have no competing interests. Authors’ Contributions: All authors contributed equally to the conception and design of the study. All authors have read and agreed to the published version of the manuscript. REFERENCES [1] CDC, "Highlights in the history of avian influenza," Retrieved: https://www.cdc.gov/bird-flu/avian- timeline/index.html. [Accessed 2024. [2] BBC News, "Avian flu devastating wales' seabirds, says RSPB," Retrieved: https://www.bbc.co.uk/news/articles/c51028p25g4o 2024. [3] D. J. Alexander, "An overview of the epidemiology of avian influenza," Vaccine, vol. 25, pp. 5637-5644, 2007. [4] V. Gamarra-Toledo et al., "Avian flu threatens Neotropical birds," Science, vol. 379, no. 6629, pp. 246-246, 2023. https://doi.org/10.1126/science.adg2271 https://www.cdc.gov/bird-flu/avian-timeline/index.html https://www.cdc.gov/bird-flu/avian-timeline/index.html https://www.bbc.co.uk/news/articles/c51028p25g4o https://doi.org/10.1126/science.adg2271 Animal Review, 2025, 12(1): 1-16 12 © 2025 Conscientia Beam. All Rights Reserved. [5] E. Stokstad, "Deadly flu spreads through North American birds," Science, vol. 376, pp. 441-442, 2022. [6] A. M. Ramey et al., "Highly pathogenic avian influenza is an emerging disease threat to wild birds in North America," The Journal of Wildlife Management, vol. 86, no. 2, p. e22171, 2022. https://doi.org/10.1002/jwmg.22171 [7] SkyNews, "Bird flu leads to 'catastrophic' fall in seabird numbers in UK, RSPB report says," Retrieved: https://news.sky.com/story/bird-flu-leads-to-catastrophic-fall-in-seabird-numbers-rspb-report-says-13070535 2024. [8] Financial Times, "Scientists express cautious optimism about decline in UK bird flu," Retrieved: https://www.ft.com/content/b8d7e222-08c9-4f32-a802-f83e36843d7c 2024. [9] BBC News, "Pirate of the seas' great skua in big decline after bird flu," Retrieved: https://www.bbc.co.uk/news/science-environment-68276680. [Accessed 07/08/24], 2024. [10] D. A. Philippon, P. Wu, B. J. Cowling, and E. H. Lau, "Avian influenza human infections at the human-animal interface," The Journal of Infectious Diseases, vol. 222, no. 4, pp. 528-537, 2020. https://doi.org/10.1093/infdis/jiaa105 [11] D. Wang, W. Zhu, L. Yang, and Y. Shu, "The epidemiology, virology, and pathogenicity of human infections with avian influenza viruses," Cold Spring Harbor Perspectives in Medicine, vol. 11, no. 4, p. a038620, 2021. https://doi.org/10.1101/cshperspect.a038620 [12] W. Song and K. Qin, "Human‐infecting influenza A (H9N2) virus: A forgotten potential pandemic strain?," Zoonoses and Public Health, vol. 67, no. 3, pp. 203-212, 2020. https://doi.org/10.1111/zph.12685 [13] BBC, "Cows in the US have bird flu - is it inching closer to humans?," Retrieved: https://www.bbc.co.uk/news/articles/clee5685w19o 2024. [14] T. Peacock et al., "The global H5N1 influenza panzootic in mammals," Nature, pp. 1-2, 2024. https://doi.org/10.1038/s41586-024-08054-z [15] E. Consortium et al., "The role of mammals in avian influenza: A review," EFSA Supporting Publications, vol. 21, no. 3, p. 8692E, 2024 https://doi.org/10.2903/sp.efsa.2024.EN-8692. [16] G. Graziosi, C. Lupini, E. Catelli, and S. Carnaccini, "Highly pathogenic avian influenza (HPAI) H5 clade 2.3. 4.4 b virus infection in birds and mammals," Animals, vol. 14, no. 9, p. 1372, 2024. https://doi.org/10.3390/ani14091372 [17] P. I. Plaza, V. Gamarra-Toledo, J. R. Euguí, and S. A. Lambertucci, "Recent changes in patterns of mammal infection with highly pathogenic avian influenza A (H5N1) virus worldwide," Emerging Infectious Diseases, vol. 30, no. 3, p. 444, 2024. https://doi.org/10.3201/eid3003.231098 [18] Google Scholar, "Google Scholar," Retrieved: https://scholar.google.co.uk/ 2024. [19] National Library of Medicine Pubmed, "Pubmed," Retrieved: https://pubmed.ncbi.nlm.nih.gov/ 2024. [20] M. Ridley and Brown, "Viral: The search for the origin of Covid‐19, cato institute United States of America," Retrieved: https://policycommons.net/artifacts/2019765/viral/2772208/ 2021. [21] L. A. Reperant and A. D. Osterhaus, "AIDS, Avian flu, SARS, MERS, Ebola, Zika… what next?," Vaccine, vol. 35, no. 35, pp. 4470-4474, 2017. [22] D. Van Riel et al., "H5N1 virus attachment to lower respiratory tract," Science, vol. 312, no. 5772, pp. 399-399, 2006. https://doi.org/10.1126/science.1125548 [23] K. R. Short et al., "Proinflammatory cytokine responses in extra-respiratory tissues during severe influenza," The Journal of Infectious Diseases, vol. 216, no. 7, pp. 829-833, 2017. https://doi.org/10.1093/infdis/jix281 [24] K. Shinya et al., "Integrated clinical, pathologic, virologic, and transcriptomic analysis of H5N1 influenza virus-induced viral pneumonia in the rhesus macaque," Journal of Virology, vol. 86, no. 11, pp. 6055-6066, 2012. https://doi.org/10.1128/jvi.00365-12 [25] Y. Sun et al., "Guinea pig model for evaluating the potential public health risk of swine and avian influenza viruses," PloS One, vol. 5, no. 11, p. e15537, 2010. https://doi.org/10.1371/journal.pone.0015537 [26] J. A. Belser, K. J. Szretter, J. M. Katz, and T. M. Tumpey, "Use of animal models to understand the pandemic potential of highly pathogenic avian influenza viruses," Advances in Virus Research, vol. 73, pp. 55-97, 2009. https://doi.org/10.1002/jwmg.22171 https://news.sky.com/story/bird-flu-leads-to-catastrophic-fall-in-seabird-numbers-rspb-report-says-13070535 https://www.ft.com/content/b8d7e222-08c9-4f32-a802-f83e36843d7c https://www.bbc.co.uk/news/science-environment-68276680 https://doi.org/10.1093/infdis/jiaa105 https://doi.org/10.1101/cshperspect.a038620 https://doi.org/10.1111/zph.12685 https://www.bbc.co.uk/news/articles/clee5685w19o https://doi.org/10.1038/s41586-024-08054-z https://doi.org/10.2903/sp.efsa.2024.EN-8692 https://doi.org/10.3390/ani14091372 https://doi.org/10.3201/eid3003.231098 https://scholar.google.co.uk/ https://pubmed.ncbi.nlm.nih.gov/ https://policycommons.net/artifacts/2019765/viral/2772208/ https://doi.org/10.1126/science.1125548 https://doi.org/10.1093/infdis/jix281 https://doi.org/10.1128/jvi.00365-12 https://doi.org/10.1371/journal.pone.0015537 Animal Review, 2025, 12(1): 1-16 13 © 2025 Conscientia Beam. All Rights Reserved. [27] T.-Q. Nguyen, R. Rollon, and Y.-K. Choi, "Animal models for influenza research: Strengths and weaknesses," Viruses, vol. 13, no. 6, p. 1011, 2021. https://doi.org/10.3390/v13061011 [28] The Guardian, "First case of walrus dying from bird flu recorded in Arctic," Retrieved: https://www.theguardian.com/world/2024/apr/30/first-walrus-bird-flu-death-arctic-islands 2024. [29] BBC News, "South Georgia: Bird flu infects penguins at famous wildlife haven," Retrieved: https://www.bbc.co.uk/news/science-environment-68538190 2024. [30] USDA, "Confirmations of highly pathogenic avian influenza in commercial and backyard flocks," Retrieved: https://www.aphis.usda.gov/livestock-poultry-disease/avian/avian-influenza/hpai-detections/commercial-backyard- flocks 2024. [31] O. G. Pyankova et al., "Isolation of clade 2.3. 4.4 b A (H5N8), a highly pathogenic avian influenza virus, from a worker during an outbreak on a poultry farm, Russia, December 2020," Eurosurveillance, vol. 26, no. 24, p. 2100439, 2021. https://doi.org/10.2807/1560-7917.es.2021.26.24.2100439 [32] CDC, "2020-2024 Highlights in the history of avian influenza (Bird Flu) timeline," Retrieved: https://www.cdc.gov/bird-flu/avian timeline/2020s.html?CDC_AAref_Val=https://www.cdc.gov/flu/avianflu/timeline/avian-timeline-2020s.htm. [Accessed 07/08/24], 2020. [33] World Organization for Animal Health, "EVENT 5636," Retrieved: https://wahis.woah.org/#/in- event/5636/dashboard. [Accessed 07/08/24], 2024. [34] USDA, "Detections of highly pathogenic avian influenza in wild birds," Retrieved: https://www.aphis.usda.gov/livestock-poultry-disease/avian/avian-influenza/hpai-detections/wild-birds. [Accessed 07/08/24], 2024. [35] World Organization for Animal Health (WOAH), Retrieved: https://www.woah.org/app/uploads/2023/09/202309- hpai-h5n1-harbor-seals-denmark.pdf. [Accessed 07/08/24], 2023. [36] World Organization for Animal Health, "EVENT 4412," Retrieved: https://wahis.woah.org/#/in- event/4412/dashboard. [Accessed 07/08/24], 2022. [37] World Organization for Animal Health, "Canada - influenza a viruses of high pathogenicity," Retrieved: https://wahis.woah.org/#/in-review/5065?reportId=166678&fromPage=event-dashboard-url. [Accessed 07/08/24], 2024. [38] Guardian, "Bird flu causing ‘catastrophic’ fall in UK seabird numbers, conservationists warn," Retrieved: https://www.theguardian.com/environment/2024/feb/13/bird-flu-uk-seabird-numbers-h5n1-great-skua-gannets. [Accessed 07/08/24], 2024. [39] RSPB, "Avian flu," Retrieved: https://www.rspb.org.uk/birds-and-wildlife/avian-influenza-updates. [Accessed 07/08/24], 2024. [40] British Trust for Ornithology, "New wave of bird flu rips through threatened gull and tern colo-nies," Retrieved: https://www.bto.org/about-bto/press-releases/new-wave-bird-flu-rips-through-threatened-gull-and-tern-colonies. [Accessed 07/8/24], 2023. [41] World Organization for Animal Health, "EVENT 5644," Retrieved: https://wahis.woah.org/#/in- event/5644/dashboard. [Accessed 07/08/24], 2024. [42] USDA, "Detections of highly pathogenic avian influenza (HPAI) in livestock," Retrieved: https://www.aphis.usda.gov/livestock-poultry-disease/avian/avian-influenza/hpai-detections/livestock. [Accessed 07/08/24], 2024. [43] World Organization for Animal Health, "United States of America - influenza a viruses of high pathogenicity," Retrieved: https://wahis.woah.org/#/in-review/4451?reportId=166488&fromPage=event-dashboard-url. [Accessed 07/08/24], 2024. https://doi.org/10.3390/v13061011 https://www.theguardian.com/world/2024/apr/30/first-walrus-bird-flu-death-arctic-islands https://www.bbc.co.uk/news/science-environment-68538190 https://www.aphis.usda.gov/livestock-poultry-disease/avian/avian-influenza/hpai-detections/commercial-backyard-flocks https://www.aphis.usda.gov/livestock-poultry-disease/avian/avian-influenza/hpai-detections/commercial-backyard-flocks https://doi.org/10.2807/1560-7917.es.2021.26.24.2100439 https://www.aphis.usda.gov/livestock-poultry-disease/avian/avian-influenza/hpai-detections/wild-birds https://www.woah.org/app/uploads/2023/09/202309-hpai-h5n1-harbor-seals-denmark.pdf https://www.woah.org/app/uploads/2023/09/202309-hpai-h5n1-harbor-seals-denmark.pdf https://wahis.woah.org/#/in-event/4412/dashboard https://wahis.woah.org/#/in-event/4412/dashboard https://wahis.woah.org/#/in-review/5065?reportId=166678&fromPage=event-dashboard-url https://www.theguardian.com/environment/2024/feb/13/bird-flu-uk-seabird-numbers-h5n1-great-skua-gannets https://www.rspb.org.uk/birds-and-wildlife/avian-influenza-updates https://www.bto.org/about-bto/press-releases/new-wave-bird-flu-rips-through-threatened-gull-and-tern-colonies https://wahis.woah.org/#/in-event/5644/dashboard https://wahis.woah.org/#/in-event/5644/dashboard https://www.aphis.usda.gov/livestock-poultry-disease/avian/avian-influenza/hpai-detections/livestock https://wahis.woah.org/#/in-review/4451?reportId=166488&fromPage=event-dashboard-url Animal Review, 2025, 12(1): 1-16 14 © 2025 Conscientia Beam. All Rights Reserved. [44] UK Health Security Agency, "HAIRS risk assessment: Avian influenza A(H5N1) in non-avian UK species," Retrieved: https://www.gov.uk/government/publications/hairs-risk-assessment-avian-influenza-ah5n1-in-non-avian-uk- wildlife/hairs-risk-assessment-avian-influenza-ah5n1-in-non-avian-uk-wildlife. [Accessed 07/08/24], 2023. [45] USDA, "Detections of highly pathogenic avian influenza in mammals," Retrieved: https://www.aphis.usda.gov/livestock-poultry-disease/avian/avian-influenza/hpai-detections/mammals. [Accessed 07/08/24], 2024. [46] World Organization for Animal Health, "H5N1 in a wild red fox in Sweden," Retrieved: https://www.woah.org/en/document/h5n1-in-a-wild-red-fox-in-sweden-august-2023/. [Accessed 07/08/24], 2023. [47] World Organization for Animal Health, "Notification of further positive HPAI results in wild mammalian species (UK)," Retrieved: https://www.woah.org/app/uploads/2023/08/202308-notification-hpai-wild-mammals-uk.pdf. [Accessed 07/08/24], 2023. [48] World Organization for Animal Health, Retrieved: https://www.woah.org/app/uploads/2023/05/notificacion-omsa-- mamiferos-marinos-chile.pdf. [Accessed 07/08/24], 2023. [49] T. Songserm et al., "Avian influenza H5N1 in naturally infected domestic cat," Emerging Infectious Diseases, vol. 12, no. 4, p. 681, 2006. https://doi.org/10.3201/eid1204.051396 [50] R. Klopfleisch et al., "Distribution of lesions and antigen of highly pathogenic avian influenza virus A/Swan/Germany/R65/06 (H5N1) in domestic cats after presumptive infection by wild birds," Veterinary Pathology, vol. 44, no. 3, pp. 261-268, 2007. https://doi.org/10.1354/vp.44-3-261 [51] CIDRAP, "Contaminated meat likely source of avian flu that killed bush dogs in UK zoo, pre-print suggests," Retrieved: https://www.cidrap.umn.edu/avian-influenza-bird-flu/contaminated-meat-likely-source-avian-flu-killed- bush-dogs-uk-zoo-preprint. [Accessed 07/08/24], 2024. [52] CDC, "H5 bird flu: Current situation," Retrieved: https://www.cdc.gov/bird-flu/situation-summary/index.html 2024. [53] M.-K. Looi, "Bird flu: US confirms second human case in two months," British Medical Journal, vol. 385, 2024. https://doi.org/10.1136/bmj.q1203 [54] BBC News, "Huge losses' of Scottish seabirds due to avian flu," Retrieved: https://www.bbc.co.uk/news/uk-scotland- north-east-orkney-shetland-67088869. [Accessed 07/08/24], 2023. [55] UK Government, "UK declares freedom from bird flu," Retrieved: https://www.gov.uk/government/news/uk- declares-freedom-from-bird-flu. [Accessed 16/09/14], 2024. [56] The Independent, "Minnesota goat becomes first to test positive for bird flu in US," Retrieved: https://www.independent.co.uk/news/world/americas/minnesota-goat-positive-bird-flu-b2517168.html. [Accessed 07/08/24], 2024. [57] K. H. Restori et al., "Risk assessment of a highly pathogenic H5N1 influenza virus from mink," Nature Communications, vol. 15, no. 1, p. 4112, 2024. https://doi.org/10.1038/s41467-024-48475-y [58] F. Fenollar et al., "Mink, SARS-CoV-2, and the human-animal interface," Frontiers in Microbiology, vol. 12, p. 663815, 2021. https://doi.org/10.3389/fmicb.2021.663815 [59] J. T. Hancock, R. C. Rouse, and T. J. Craig, Animal welfare in a pandemic: What does COVID-19 tell us for the future? Boca Raton: CRC Press, 2024. [60] BBC News, "Cows, dairy workers, and America's struggle to track bird flu," Retrieved: https://www.bbc.co.uk/news/articles/ce98zmpq467o. [Accessed 16/09/24], 2024. [61] G. Neumann and Y. Kawaoka, "Highly pathogenic H5N1 avian influenza virus outbreak in cattle: The knowns and unknowns," Nature Reviews Microbiology, vol. 22, no. 9, pp. 525-526, 2024. https://doi.org/10.1038/s41579-024- 01087-1 [62] Telegraph Newspaper, "Cats died from bird flu ‘after consuming raw milk from infected cows," Retrieved: https://www.telegraph.co.uk/global-health/science-and-disease/bird-flu-outbreak-us-cattle-farms-cat-deaths/ 2024. https://www.gov.uk/government/publications/hairs-risk-assessment-avian-influenza-ah5n1-in-non-avian-uk-wildlife/hairs-risk-assessment-avian-influenza-ah5n1-in-non-avian-uk-wildlife https://www.gov.uk/government/publications/hairs-risk-assessment-avian-influenza-ah5n1-in-non-avian-uk-wildlife/hairs-risk-assessment-avian-influenza-ah5n1-in-non-avian-uk-wildlife https://www.aphis.usda.gov/livestock-poultry-disease/avian/avian-influenza/hpai-detections/mammals https://www.woah.org/en/document/h5n1-in-a-wild-red-fox-in-sweden-august-2023/ https://www.woah.org/app/uploads/2023/08/202308-notification-hpai-wild-mammals-uk.pdf https://www.woah.org/app/uploads/2023/05/notificacion-omsa--mamiferos-marinos-chile.pdf https://www.woah.org/app/uploads/2023/05/notificacion-omsa--mamiferos-marinos-chile.pdf https://doi.org/10.3201/eid1204.051396 https://doi.org/10.1354/vp.44-3-261 https://www.cidrap.umn.edu/avian-influenza-bird-flu/contaminated-meat-likely-source-avian-flu-killed-bush-dogs-uk-zoo-preprint https://www.cidrap.umn.edu/avian-influenza-bird-flu/contaminated-meat-likely-source-avian-flu-killed-bush-dogs-uk-zoo-preprint https://www.cdc.gov/bird-flu/situation-summary/index.html https://doi.org/10.1136/bmj.q1203 https://www.bbc.co.uk/news/uk-scotland-north-east-orkney-shetland-67088869 https://www.bbc.co.uk/news/uk-scotland-north-east-orkney-shetland-67088869 https://www.gov.uk/government/news/uk-declares-freedom-from-bird-flu https://www.gov.uk/government/news/uk-declares-freedom-from-bird-flu https://www.independent.co.uk/news/world/americas/minnesota-goat-positive-bird-flu-b2517168.html https://doi.org/10.1038/s41467-024-48475-y https://doi.org/10.3389/fmicb.2021.663815 https://www.bbc.co.uk/news/articles/ce98zmpq467o https://doi.org/10.1038/s41579-024-01087-1 https://doi.org/10.1038/s41579-024-01087-1 https://www.telegraph.co.uk/global-health/science-and-disease/bird-flu-outbreak-us-cattle-farms-cat-deaths/ Animal Review, 2025, 12(1): 1-16 15 © 2025 Conscientia Beam. All Rights Reserved. [63] ScienceNews, "Bird flu can infect cats. What does that mean for their people? ," Retrieved: https://www.sciencenews.org/article/bird-flu-h5n1-infect-cats-people. [Accessed 07/08/24], 2024. [64] J. Segalés et al., "Detection of SARS-CoV-2 in a cat owned by a COVID-19− affected patient in Spain," Proceedings of the National Academy of Sciences, vol. 117, no. 40, pp. 24790-24793, 2020. [65] M. J. Hosie et al., "Anthropogenic infection of cats during the 2020 COVID-19 pandemic," Viruses, vol. 13, no. 2, p. 185, 2021. https://doi.org/10.3390/v13020185 [66] WHO, "Influenza A(H5N1) in cats – Poland," Retrieved: https://www.who.int/emergencies/disease-outbreak- news/item/2023-DON476. [Accessed 07/08/24], 2023. [67] RSPB, "Avian influenza: A major threat to our struggling seabirds," Retrieved: https://www.rspb.org.uk/birds-and- wildlife/seabird-surveys-project-report. [Accessed 16/09/24], 2023. [68] RSPB, "UK seabird colony counts in 2023 following the 2021-22 outbreak of highly Patho-genic Avian influenza research report 76," Retrieved: RSPBHPAIseabirdcountsreport_Feb24.pdf 2024. [69] C. J. Cardona, Z. Xing, C. E. Sandrock, and C. E. Davis, "Avian influenza in birds and mammals," Comparative Immunology, Microbiology and Infectious Diseases, vol. 32, no. 4, pp. 255-273, 2009. [70] UK Government, "Bird flu (avian influenza): Latest situation in England," Retrieved: https://www.gov.uk/government/news/bird-flu-avian-influenza-latest-situation-in-england. [Accessed 07/08/24], 2022. [71] ECDC, "Questions and answers on avian influenza," Retrieved: https://www.ecdc.europa.eu/en/zoonotic- influenza/facts/faq-avian- influenza#:~:text=Transmission%20to%20other%20wild%20mammals,avoided%2C%20especially%20in%20affected% 20areas. [Accessed 07/08/24], 2023. [72] Food and Agriculture Organization of the United Nations, "Global avian influenza viruses with zoonotic potential situation update," Retrieved: https://www.fao.org/animal-health/situation-updates/global-aiv-with-zoonotic- potential/bird-species-affected-by-h5nx-hpai/en. [Accessed 07/08/24], 2024. [73] J. Charostad et al., "A comprehensive review of highly pathogenic avian influenza (HPAI) H5N1: An imminent threat at doorstep," Travel Medicine and Infectious Disease, p. 102638, 2023. https://doi.org/10.1016/j.tmaid.2023.102638 [74] BBC News, "What is bird flu and how worried should I be about a pandemic?," Retrieved: https://www.bbc.co.uk/news/science-environment-63464065. [Accessed 07/08/24], 2024. [75] The BJM, "Should we worry about a growing threat from “bird flu”?," Retrieved: https://www.bmj.com/content/385/bmj.q1199. [Accessed 07/08/24], 2024. [76] L. R. Pripon, "Natural object or element of an artwork? Case study: Artists, artworks and exhibitions in Cluj, Romania," Studia Universitatis Babes-Bolyai-Philosophia, vol. 65, no. Sp. Issue, pp. 159-172, 2020. https://doi.org/10.24193/subbphil.2020.spiss.12 [77] BBC News, "Man in Mexico dies with first human case of H5N2 bird flu," Retrieved: https://www.bbc.co.uk/news/articles/cneejz1kdzmo. [Accessed 07/08/24], 2024. [78] H. Brüssow, "Avian influenza virus cross‐infections as test case for pandemic preparedness: From epidemiological hazard models to sequence‐based early viral warning systems," Microbial Biotechnology, vol. 17, no. 1, p. e14389, 2024. https://doi.org/10.1111/1751-7915.14389 [79] WHO, "Pandemic prevention, preparedness and response accord," Retrieved: https://www.who.int/news- room/questions-and-answers/item/pandemic-prevention--preparedness-and-response-accord. [Accessed 16/09/24], 2024. [80] Telegraph, "California’s ‘wellness’ devotees think raw milk infected with bird flu will ‘boost immunity’," Retrieved: https://www.telegraph.co.uk/global-health/science-and-disease/bird-flu-raw-unpasteurised-h5n1-infected-milk- california/. [Accessed 07/08/24], 2024. https://www.sciencenews.org/article/bird-flu-h5n1-infect-cats-people https://doi.org/10.3390/v13020185 https://www.who.int/emergencies/disease-outbreak-news/item/2023-DON476 https://www.who.int/emergencies/disease-outbreak-news/item/2023-DON476 https://www.rspb.org.uk/birds-and-wildlife/seabird-surveys-project-report https://www.rspb.org.uk/birds-and-wildlife/seabird-surveys-project-report RSPBHPAIseabirdcountsreport_Feb24.pdf https://www.gov.uk/government/news/bird-flu-avian-influenza-latest-situation-in-england https://www.ecdc.europa.eu/en/zoonotic-influenza/facts/faq-avian-influenza#:~:text=Transmission%20to%20other%20wild%20mammals,avoided%2C%20especially%20in%20affected%20areas https://www.ecdc.europa.eu/en/zoonotic-influenza/facts/faq-avian-influenza#:~:text=Transmission%20to%20other%20wild%20mammals,avoided%2C%20especially%20in%20affected%20areas https://www.ecdc.europa.eu/en/zoonotic-influenza/facts/faq-avian-influenza#:~:text=Transmission%20to%20other%20wild%20mammals,avoided%2C%20especially%20in%20affected%20areas https://www.ecdc.europa.eu/en/zoonotic-influenza/facts/faq-avian-influenza#:~:text=Transmission%20to%20other%20wild%20mammals,avoided%2C%20especially%20in%20affected%20areas https://www.fao.org/animal-health/situation-updates/global-aiv-with-zoonotic-potential/bird-species-affected-by-h5nx-hpai/en https://www.fao.org/animal-health/situation-updates/global-aiv-with-zoonotic-potential/bird-species-affected-by-h5nx-hpai/en https://doi.org/10.1016/j.tmaid.2023.102638 https://www.bbc.co.uk/news/science-environment-63464065 https://www.bmj.com/content/385/bmj.q1199 https://doi.org/10.24193/subbphil.2020.spiss.12 https://www.bbc.co.uk/news/articles/cneejz1kdzmo https://doi.org/10.1111/1751-7915.14389 https://www.who.int/news-room/questions-and-answers/item/pandemic-prevention--preparedness-and-response-accord https://www.who.int/news-room/questions-and-answers/item/pandemic-prevention--preparedness-and-response-accord https://www.telegraph.co.uk/global-health/science-and-disease/bird-flu-raw-unpasteurised-h5n1-infected-milk-california/ https://www.telegraph.co.uk/global-health/science-and-disease/bird-flu-raw-unpasteurised-h5n1-infected-milk-california/ Animal Review, 2025, 12(1): 1-16 16 © 2025 Conscientia Beam. All Rights Reserved. [81] The Associated Press, "Bird flu is highly lethal to some animals, but not to others. Scientists want to know why," Retrieved: https://apnews.com/article/bird-flu-humans-animals-deaths- ae01d3717783f0cf41e23f3fedb97017?utm_source=Live+Audience&utm_campaign=507caab053-nature-briefing-daily- 20240618&utm_medium=email&utm_term=0_b27a691814-507caab053-50657140. [Accessed 07/08/24], 2024. [82] A. J. Eisfeld et al., "Pathogenicity and transmissibility of bovine H5N1 influenza virus," Nature, vol. 633, no. 8029, pp. 426-432, 2024. https://doi.org/10.1038/s41586-024-07766-6 Views and opinions expressed in this article are the views and opinions of the author(s), Animal Review shall not be responsible or answerable for any loss, damage or liability etc. caused in relation to/arising out of the use of the content. https://apnews.com/article/bird-flu-humans-animals-deaths-ae01d3717783f0cf41e23f3fedb97017?utm_source=Live+Audience&utm_campaign=507caab053-nature-briefing-daily-20240618&utm_medium=email&utm_term=0_b27a691814-507caab053-50657140 https://apnews.com/article/bird-flu-humans-animals-deaths-ae01d3717783f0cf41e23f3fedb97017?utm_source=Live+Audience&utm_campaign=507caab053-nature-briefing-daily-20240618&utm_medium=email&utm_term=0_b27a691814-507caab053-50657140 https://apnews.com/article/bird-flu-humans-animals-deaths-ae01d3717783f0cf41e23f3fedb97017?utm_source=Live+Audience&utm_campaign=507caab053-nature-briefing-daily-20240618&utm_medium=email&utm_term=0_b27a691814-507caab053-50657140 https://doi.org/10.1038/s41586-024-07766-6