# bib

id: cord-026421-ygocpnht
author: de Jager, Pauline
title: Response to the authors
date: 2020-06-08
extension: .txt
mime: text/plain
words: 704
sentence: 29
flesch: 44
cache: cache/cord-026421-ygocpnht.txt
txt: txt/cord-026421-ygocpnht.txt
summary:
  Feasibility of an alternative, physiologic, individualized openlung approach to high-frequency oscillatory ventilation in children Lung volume optimization maneuver responses in pediatric high frequency oscillatory ventilation Understanding the pressure cost of ventilation: why does high-frequency ventilation work? Recommendations for mechanical ventilation of critically ill children from the Paediatric Mechanical Ventilation Consensus Conference (PEMVECC) PEEP lower than the ARDS network protocol is associated with higher pediatric ARDS mortality Tidal volume and mortality in mechanically ventilated children: a systematic review and meta-analysis of observational studies* High-frequency oscillatory ventilation for PARDS: awaiting PROSPect Not applicable. To date, there is no specific PEEP strategy shown to be beneficial nor are there outcome data demonstrating that higher PEEP is better than lower PEEP in PARDS, although there are some suggestions that lower PEEP in PARDS may be associated with increased mortality


id: cord-269161-6nsvup68
author: Kapoor, Indu
title: Vitamins as adjunctive treatment for coronavirus disease!
date: 2020-09-29
extension: .txt
mime: text/plain
words: 654
sentence: 35
flesch: 44
cache: cache/cord-269161-6nsvup68.txt
txt: txt/cord-269161-6nsvup68.txt
summary:
  A controlled human trial has reported that Vitamin C significantly lowers the incidence of pneumonia, suggesting that vitamin C may affect susceptibility to lower respiratory tract infections Vitamins A, B6, B12, C, D and E work synergistically to support the protective activities of the immune cells.


id: cord-280965-x5ffw843
author: Damiani, Elisa
date: 2020-10-23
extension: .txt
mime: text/plain
words: 812
sentence: 41
flesch: 35
cache: cache/cord-280965-x5ffw843.txt
txt: txt/cord-280965-x5ffw843.txt
title:
  Comment on “Respiratory mechanics and gas exchanges in the early course of COVID-19 ARDS: a hypothesis-generating study”

summary:
  Appropriately designed clinical and laboratory-controlled studies are needed to prove any causal relationship between microvascular derangements and increased dead space ventilation. Several hypotheses are made to explain the pathogenesis of increased V D /V


id: cord-345674-wkwqlnz2
author: Kobayashi, Jun
date: 2020-05-20
extension: .txt
mime: text/plain
words: 859
sentence: 36
flesch: 35
cache: cache/cord-345674-wkwqlnz2.txt
txt: txt/cord-345674-wkwqlnz2.txt
title:
  Nitric oxide inhalation as an interventional rescue therapy for COVID-19-induced acute respiratory distress syndrome

summary:
  However, inhaled nitric oxide has not yet been formally evaluated. Given the extent of the COVID-19 pandemic, and the large numbers of hospitalized patients requiring respiratory support, clinical use of inhaled nitric oxide may become an alternate rescue therapy before extracorporeal membrane oxygenation for the management of acute respiratory distress syndrome in patients with COVID-19.


id: cord-316681-b46ycocg
author: Rutsaert, Lynn
title: COVID-19-associated invasive pulmonary aspergillosis
date: 2020-06-01
extension: .txt
mime: text/plain
words: 1235
sentence: 61
flesch: 38
cache: cache/cord-316681-b46ycocg.txt
txt: txt/cord-316681-b46ycocg.txt
summary:
  SARS-CoV-2 infection among travelers returning from Wuhan, China Invasive pulmonary aspergillosis The clinical spectrum of pulmonary aspergillosis Invasive aspergillosis in patients admitted to the intensive care unit with severe influenza: a retrospective cohort study Invasive pulmonary aspergillosis complicating severe influenza: epidemiology, diagnosis and treatment Diagnosing invasive pulmonary aspergillosis in ICU patients: putting the puzzle together Revised definitions of invasive fungal disease from the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) Consensus Group Inhaled amphotericin B as aspergillosis prophylaxis in hematologic disease: an update. In our 24-bedded mixed ICU, we have encountered an unexpectedly high number of COVID-19 patients developing invasive pulmonary aspergillosis.


id: cord-004138-5nvhtqoh
author: Pouly, Olivier
date: 2020-01-13
extension: .txt
mime: text/plain
words: 3062
sentence: 165
flesch: 44
cache: cache/cord-004138-5nvhtqoh.txt
txt: txt/cord-004138-5nvhtqoh.txt
title:
  Accuracy of ventilator-associated events for the diagnosis of ventilator-associated lower respiratory tract infections

summary:
  The strengths of our study include the large number of included patients (n = 1059) and ventilator days (n = 15,029), and the prospective evaluation of all VA-LRTI, including VAT. In addition, the recent ATS/IDSA guidelines on VAP recommended not treating VAT patients with antimicrobial, based on the low quality of the available evidence [9] .


id: cord-344647-jr85915d
author: Joseph, Adrien
title: Acute kidney injury in patients with SARS-CoV-2 infection
date: 2020-09-03
extension: .txt
mime: text/plain
words: 3551
sentence: 164
flesch: 48
cache: cache/cord-344647-jr85915d.txt
txt: txt/cord-344647-jr85915d.txt
summary:
  Last, high levels of PEEP in COVID-19 patients [34, 35] have also been suggested as a potential factor for increased AKI in severe COVID-19 patients [36] . Before adjustment, the third fraction of complement (C3), interleukin-6 (IL-6) and ferritin levels were higher in AKI patients.


id: cord-004462-e8fbg6i6
author: Liu, Songqiao
date: 2020-03-06
extension: .txt
mime: text/plain
words: 3652
sentence: 176
flesch: 45
cache: cache/cord-004462-e8fbg6i6.txt
txt: txt/cord-004462-e8fbg6i6.txt
title:
  Optimal mean airway pressure during high-frequency oscillatory ventilation in an experimental model of acute respiratory distress syndrome: EIT-based method

summary:
  EIT-based COV index higher than 50% at high mPaw steps indicated ventilation distribution toward gravity-dependent regions. The differences of impedance between lower mPaw and higher mPaw were calculated.


id: cord-025157-7b3v5yct
author: Darreau, C.
date: 2020-05-24
extension: .txt
mime: text/plain
words: 3621
sentence: 167
flesch: 37
cache: cache/cord-025157-7b3v5yct.txt
txt: txt/cord-025157-7b3v5yct.txt
title:
  Use, timing and factors associated with tracheal intubation in septic shock: a prospective multicentric observational study

summary:
  Neurological, respiratory and hemodynamic parameters only partially explained the use of tracheal intubation in septic shock patients. To assess use, timing and factors associated with tracheal intubation in septic shock patients, we conducted a multicenter observational prospective study in 30 intensive care units (ICUs) in France and Spain.


id: cord-003798-nki2sasr
author: Vidaur, Loreto
date: 2019-07-24
extension: .txt
mime: text/plain
words: 3506
sentence: 160
flesch: 37
cache: cache/cord-003798-nki2sasr.txt
txt: txt/cord-003798-nki2sasr.txt
title:
  Human metapneumovirus as cause of severe community-acquired pneumonia in adults: insights from a ten-year molecular and epidemiological analysis

summary:
  In a large prospective study of ICU patients requiring invasive mechanical ventilation, hMPV was more frequently detected in patients admitted by severe respiratory infection than in patients with other causes, suggesting a causal role of HMPV in the development of severe respiratory infection [24] . Bacterial pneumonia Procalcitonin (PCT) levels for ruling-out bacterial coinfection in ICU patients with influenza: a CHAID decision-tree analysis Effect of procalcitonin guided guidelines vs standard guidelines on antibiotic use in lower respiratory tract infections: the Pro-HOSP randomized controlled trial Procalcitonin guidance of antibiotic therapy in community acquired pneumonia: a randomized trial Towards precision medicine in sepsis: a position paper from the European Society of Clinical Microbiology and Infectious Diseases The role of human Metapneumovirus genetic diversity and nasopharyngeal load on symptom severity in adults LV made substantial contribution to the conception and design of the work, the acquisition, analysis and interpretation of the data and has drafted the work.


id: cord-311176-dlwph5za
author: Alshahrani, Mohammed S.
title: Extracorporeal membrane oxygenation for severe Middle East respiratory syndrome coronavirus
date: 2018-01-10
extension: .txt
mime: text/plain
words: 3697
sentence: 156
flesch: 44
cache: cache/cord-311176-dlwph5za.txt
txt: txt/cord-311176-dlwph5za.txt
summary:
  Blood flow (L min −1 ), revolutions per minute, and sweep gas among ECMO patients had a mean (SD) of 3.8 (0.77), 3148.7 ECMO-related mechanical complications occurred in 3 (18%) patients; one patient developed pneumothorax that was treated with chest tube insertion, and two patients had major bleeding immediately after the initiation of ECMO. In regard to infection control issues, caregivers safety of ECMO patients was organized and maintained by aggressive measures which were applied strictly and monitored closely with all admissions were taken to airborne isolated rooms which impacted the containment of the virus plus applying the universal protective personal measures all the time during the patients encounter.


id: cord-328569-1lx3fkv3
author: Bagate, François
date: 2020-11-04
extension: .txt
mime: text/plain
words: 3769
sentence: 187
flesch: 44
cache: cache/cord-328569-1lx3fkv3.txt
txt: txt/cord-328569-1lx3fkv3.txt
title:
  Rescue therapy with inhaled nitric oxide and almitrine in COVID-19 patients with severe acute respiratory distress syndrome

summary:
  During the first SARS-CoV outbreak in 2004, a pilot study reported the efficacy of iNO in a limited series of severe patients, with reversal of pulmonary hypertension, improved hypoxemia and shortened duration of mechanical ventilation [20] . The NO Almitrine Study Group Inhaled nitric oxide and vasoconstrictors in acute respiratory distress syndrome Additive effect on gas exchange of inhaled nitric oxide and intravenous almitrine bismesylate in the adult respiratory distress syndrome Acute respiratory distress syndrome: the Berlin Definition Formal guidelines: management of acute respiratory distress syndrome Efficacy of prone position in acute respiratory distress syndrome patients: A pathophysiology-based review Potential for lung recruitment estimated by the recruitment-toinflation ratio in acute respiratory distress syndrome a clinical trial Prevalence and prognosis of cor pulmonale during protective ventilation for acute respiratory distress syndrome Prevalence and prognosis of shunting across patent foramen ovale during acute respiratory distress syndrome The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure.


id: cord-004284-2prli5s1
author: Vahedian-Azimi, Amir
title: Natural versus artificial light exposure on delirium incidence in ARDS patients
date: 2020-02-05
extension: .txt
mime: text/plain
words: 776
sentence: 33
flesch: 34
cache: cache/cord-004284-2prli5s1.txt
txt: txt/cord-004284-2prli5s1.txt
summary:
  key: cord-004284-2prli5s1 authors: Vahedian-Azimi, Amir; Bashar, Farshid R.; Khan, Abbas M.; Miller, Andrew C. title: Natural versus artificial light exposure on delirium incidence in ARDS patients date: 2020-02-05 journal: Ann Intensive Care DOI: 10.1186/s13613-020-0630-8 sha: doc_id: 4284 cord_uid: 2prli5s1 nan We read with interest the study by Smonig et al. No difference in delirium incidence or duration, MV duration, self-extubation, ICU or hospital length-of-stay (LOS), or mortality was observed [1] .


id: cord-346115-xilbhy37
author: Gattinoni, Luciano
title: COVID-19: scientific reasoning, pragmatism and emotional bias
date: 2020-10-12
extension: .txt
mime: text/plain
words: 1107
sentence: 49
flesch: 47
cache: cache/cord-346115-xilbhy37.txt
txt: txt/cord-346115-xilbhy37.txt
summary:
  Another example is provided when Tobin et al. say Patients with acute severe asthma develop large pleural Open Access *Correspondence: gattinoniluciano@gmail.com 1 Yet, it seems to us that most of the arguments, counterarguments, attempts to correct, disparage and set-therecord-straight expressed by Tobin et al.


id: cord-002011-u6dfp6gf
author: Toubiana, Julie
title: Association of REL polymorphisms and outcome of patients with septic shock
date: 2016-04-08
extension: .txt
mime: text/plain
words: 3960
sentence: 170
flesch: 44
cache: cache/cord-002011-u6dfp6gf.txt
txt: txt/cord-002011-u6dfp6gf.txt
summary:
  The present study showed that septic shock patients carrying the rs842647*G minor allele had an over risk of MODS and mortality. This study was the first to investigate the importance of two polymorphisms within REL gene in a large European population of septic shock patients.


id: cord-000812-mu5u5bvj
author: Wiesen, Jonathan
date: 2012-08-28
extension: .txt
mime: text/plain
words: 4101
sentence: 154
flesch: 40
cache: cache/cord-000812-mu5u5bvj.txt
txt: txt/cord-000812-mu5u5bvj.txt
title:
  Relative cost and outcomes in the intensive care unit of acute lung injury (ALI) due to pandemic influenza compared with other etiologies: a single-center study

summary:
  World now at the start of 2009 influenza pandemic California Pandemic (H1N1) Working Group: Severe 2009 H1N1 influenza in pregnant and postpartum women in California Pediatric hospitalizations associated with 2009 pandemic influenza A (H1N1) in Argentina Critical care services and H1N1 influenza in Australia and New Zealand Extracorporeal Membrane Oxygenation for 2009 Influenza A(H1N1) Acute Respiratory Distress Syndrome Critically Ill patients with 2009 influenza A(H1N1) in Mexico Intensive care adult patients with severe respiratory failure caused by Influenza A (H1N1)v in Spain Critically ill patients with 2009 influenza A(H1N1) infection in Canada Pandemic (H1N1) 2009: epidemiological, clinical and prevention aspects Hospitalized patients with 2009 H1N1 influenza in the United States Pandemic (H1N1) 2009 influenza Writing Committee of the WHO Consultation on Clinical Aspects of Pandemic (H1N1) 2009 Influenza, Bautista E, Chotpitayasunondh T: Clinical aspects of pandemic 2009 influenza A (H1N1) virus infection Clinical management of pandemic 2009 influenza A(H1N1) infection H1N1: viral pneumonia as a cause of acute respiratory distress syndrome Ventilator management for hypoxemic respiratory failure attributable to H1N1 novel swine origin influenza virus Hospitalized patients with 2009 H1N1 influenza infection: the Mayo Clinic experience Clinical findings and demographic factors associated with ICU admission in Utah due to novel 2009 influenza A(H1N1) infection The macroeconomic impact of pandemic influenza: estimates from models of the United Kingdom, France, Belgium and The Netherlands Cost-effectiveness analysis of hospital infection control response to an epidemic respiratory virus threat Economic consequences to society of pandemic H1N1 influenza 2009 -preliminary results for Sweden Effectiveness and cost-effectiveness of vaccination against pandemic influenza (H1N1) 2009 Research electronic data capture (REDCap)-a metadata-driven methodology and workflow process for providing translational research informatics support Severe refractory hypoxaemia in H1N1 (2009) intensive care patients: initial experience in an Asian regional hospital Lung recruitment in patients with the acute respiratory distress syndrome Epidemiology and outcomes of acute lung injury Effect of a protective-ventilation strategy on mortality in the acute respiratory distress syndrome Adult respiratory distress syndrome: hospital charges and outcome according to underlying disease Variable costs of ICU patients: a multicenter prospective study Relative cost and outcomes in the intensive care unit of acute lung injury (ALI) due to pandemic influenza compared with other etiologies: a single-center study The authors declare that they have no competing interests. Compared with other studies of pandemic influenza patients who required mechanical ventilation, SOFA scores (mean 8.3) were similar, although APACHE II (25 ± 9) scores were higher [5] [6] [7] [8] 14, 16, 17, 23] .


id: cord-278993-w5aa0elj
author: Tonetti, Tommaso
date: 2020-10-12
extension: .txt
mime: text/plain
words: 3929
sentence: 127
flesch: 37
cache: cache/cord-278993-w5aa0elj.txt
txt: txt/cord-278993-w5aa0elj.txt
title:
  Use of critical care resources during the first 2 weeks (February 24–March 8, 2020) of the Covid-19 outbreak in Italy

summary:
  In patients treated outside the ICU, conventional O 2 therapy was applied in the 47.3% of the cases and non-invasive respiratory support (including NIV, CPAP and high-flow O 2 therapy) in the 52.7%, while 81.8% of ICU patients were intubated. Data regarding the impact of Covid-19 outbreak on the capacity of the health-care system to accomplish the need for ICU care are limited.


id: cord-325599-2gutb4m1
author: Lapidus, Nathanael
date: 2020-10-16
extension: .txt
mime: text/plain
words: 4401
sentence: 164
flesch: 45
cache: cache/cord-325599-2gutb4m1.txt
txt: txt/cord-325599-2gutb4m1.txt
title:
  Biased and unbiased estimation of the average length of stay in intensive care units in the Covid-19 pandemic

summary:
  For example, one may think about the impact of disease knowledge on triage decisions and on the decision to withdraw early mechanical ventilation based on refinement of prognostic factors (ethical issues), bed availability and pressure of this threatening epidemic on the organization of the healthcare system likely modifies the characteristics of admitted patients as well as various specific characteristics of the units (including cultural behaviors), accumulating experience with COVID-19 patients likely improves management procedures according to time. Third and to conclude, whenever the estimates reported in this study would be generalizable to other settings, then this is bad news: long ICU LOS as reported here imply that occupied beds remain unavailable for a long time and this adds additional pressure to the surge in ICU beds encountered in many places worldwide.


id: cord-003219-iryb3v0z
author: Kao, Kuo-Chin
date: 2018-09-24
extension: .txt
mime: text/plain
words: 4380
sentence: 186
flesch: 41
cache: cache/cord-003219-iryb3v0z.txt
txt: txt/cord-003219-iryb3v0z.txt
title:
  Predictors of survival in patients with influenza pneumonia-related severe acute respiratory distress syndrome treated with prone positioning

summary:
  [16] studied H7N9 influenza patients with prone positioning, and decrease in carbon dioxide retention was noted, but no clinical outcome was mentioned. Our previous study for severe ARDS patients with ECMO revealed that higher dynamic driving pressure [hazard ratio 1.070 (1.026-1.116), p = 0.002] during the first 3 days of ECMO was one of the factors independently associated with ICU mortality


id: cord-029984-sjvqjoye
author: Gaudet, Alexandre
date: 2020-08-03
extension: .txt
mime: text/plain
words: 4524
sentence: 180
flesch: 39
cache: cache/cord-029984-sjvqjoye.txt
txt: txt/cord-029984-sjvqjoye.txt
title:
  Accuracy of the clinical pulmonary infection score to differentiate ventilator-associated tracheobronchitis from ventilator-associated pneumonia

summary:
  Furthermore, at the day of VAP diagnosis, they observed that a single measurement of CRP was useful in particular for the exclusion of VAP diagnosis. A proposed solution for indiscriminate antibiotic prescription Diagnostic accuracy of clinical pulmonary infection score for ventilator-associated pneumonia: a meta-analysis Management of Adults With Hospital-acquired and Ventilatorassociated Pneumonia: 2016 Clinical Practice Guidelines by the Infectious Diseases Society of America and the Infection Probability Score (IPS): a method to help assess the probability of infection in critically ill patients Usefulness of procalcitonin for the diagnosis of ventilator-associated pneumonia Serum procalcitonin for the early recognition of nosocomial infection in the critically ill patients: a preliminary report Biomarker kinetics in the prediction of VAP diagnosis: results from the BioVAP study Soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) as a diagnostic marker of ventilator-associated pneumonia Soluble triggering receptor expressed on myeloid cells-1 in bronchoalveolar lavage fluid is not predictive for ventilator-associated pneumonia Lung ultrasound for diagnosis and monitoring of ventilator-associated pneumonia High discordance of chest x-ray and computed tomography for detection of pulmonary opacities in ED patients: implications for diagnosing pneumonia


id: cord-004438-jjszkq2n
author: Gavelli, Francesco
date: 2020-03-02
extension: .txt
mime: text/plain
words: 4701
sentence: 217
flesch: 49
cache: cache/cord-004438-jjszkq2n.txt
txt: txt/cord-004438-jjszkq2n.txt
title:
  Transpulmonary thermodilution detects rapid and reversible increases in lung water induced by positive end-expiratory pressure in acute respiratory distress syndrome

summary:
  One animal [8] and three human studies [6, 7, 28] have investigated the effects of PEEP changes on TPTD-estimated EVLW, three suggesting that EVLW increases with PEEP [6] [7] [8] and another one that it remains unchanged [28] . When the same analysis was performed by estimating recruitment according to lung volume changes (n = 30), CVP remained significantly associated to the changes in EVLW (p < 0.001).


id: cord-032831-mupxzffk
author: Diehl, J.-L.
title: Physiological effects of adding ECCO(2)R to invasive mechanical ventilation for COPD exacerbations
date: 2020-09-29
extension: .txt
mime: text/plain
words: 5074
sentence: 200
flesch: 44
cache: cache/cord-032831-mupxzffk.txt
txt: txt/cord-032831-mupxzffk.txt
summary:
  Only a small number of IMV COPD patients were studied under ECCO 2 R, with the aim to facilitate extubation [10] [11] key: cord-032831-mupxzffk authors: Diehl, J.-L.; Piquilloud, L.; Vimpere, D.; Aissaoui, N.; Guerot, E.; Augy, J. L.; Pierrot, M.; Hourton, D.; Arnoux, A.; Richard, C.; Mancebo, J.; Mercat, A. title: Physiological effects of adding ECCO(2)R to invasive mechanical ventilation for COPD exacerbations date: 2020-09-29 journal: Ann Intensive Care DOI: 10.1186/s13613-020-00743-y sha: doc_id: 32831 cord_uid: mupxzffk BACKGROUND: Extracorporeal CO(2) removal (ECCO(2)R) could be a valuable additional modality for invasive mechanical ventilation (IMV) in COPD patients suffering from severe acute exacerbation (AE).


id: cord-026885-ql57moyi
author: Hong, David
date: 2020-06-16
extension: .txt
mime: text/plain
words: 5022
sentence: 213
flesch: 37
cache: cache/cord-026885-ql57moyi.txt
txt: txt/cord-026885-ql57moyi.txt
title:
  Multidisciplinary team approach in acute myocardial infarction patients undergoing veno-arterial extracorporeal membrane oxygenation

summary:
  However, after the foundation of the ECMO team, team members readily participated in the management of ECMO patients and all ECMO-related decisions, as described below. Third, ECMO-trained physicians, cardiovascular surgeons, and perfusionists provided 24-h on-call coverage for ECMO patients and potential candidates.


id: cord-004002-b35wm2db
author: Gaborit, Benjamin Jean
date: 2019-11-27
extension: .txt
mime: text/plain
words: 4895
sentence: 187
flesch: 34
cache: cache/cord-004002-b35wm2db.txt
txt: txt/cord-004002-b35wm2db.txt
title:
  Outcome and prognostic factors of Pneumocystis jirovecii pneumonia in immunocompromised adults: a prospective observational study

summary:
  Lymphocytes and neutrophils mean ratio were, respectively, 22% and 23% in HIV patients, 34% and 21% in non-HIV patients, 22% and 30% in dead patients, 35% and 19% in survivors patients, 36% and 21% with only PJP patients, 29% and 22% during coinfection. In survival analysis HIV patients presenting with PJP was associated with statistically better prognostic than that of patients with hematologic diseases or solid cancer (Additional file 1: Figures S2, S3) .


id: cord-009600-sb1pgqi8
author: Ospina-Tascón, Gustavo A.
title: Diastolic shock index and clinical outcomes in patients with septic shock
date: 2020-04-16
extension: .txt
mime: text/plain
words: 5227
sentence: 192
flesch: 38
cache: cache/cord-009600-sb1pgqi8.txt
txt: txt/cord-009600-sb1pgqi8.txt
summary:
  Septic shock was defined in the ANDROMEDA-SHOCK population according to the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis 3.0), which states septic shock as the combination of suspected infection accompanying life-threatening organ dysfunction, requirement of vasopressor therapy to elevate MAP ≥ 65 mmHg and lactate > 2 mmol/L despite adequate fluid resuscitation [22] . key: cord-009600-sb1pgqi8 authors: Ospina-Tascón, Gustavo A.; Teboul, Jean-Louis; Hernandez, Glenn; Alvarez, Ingrid; Sánchez-Ortiz, Alvaro I.; Calderón-Tapia, Luis E.; Manzano-Nunez, Ramiro; Quiñones, Edgardo; Madriñan-Navia, Humberto J.; Ruiz, Juan E.; Aldana, José L.; Bakker, Jan title: Diastolic shock index and clinical outcomes in patients with septic shock date: 2020-04-16 journal: Ann Intensive Care DOI: 10.1186/s13613-020-00658-8 sha: doc_id: 9600 cord_uid: sb1pgqi8 BACKGROUND: Loss of vascular tone is a key pathophysiological feature of septic shock.


id: cord-003198-1kw5v6rm
author: Vuillard, Constance
date: 2018-09-11
extension: .txt
mime: text/plain
words: 4860
sentence: 191
flesch: 36
cache: cache/cord-003198-1kw5v6rm.txt
txt: txt/cord-003198-1kw5v6rm.txt
title:
  Clinical features and outcome of patients with acute respiratory failure revealing anti-synthetase or anti-MDA-5 dermato-pulmonary syndrome: a French multicenter retrospective study

summary:
  22 Service de Réanimation médicale Unité de Réanimation et de Surveillance continue, Service de Pneumologie et Réanimation médicale, Groupe hospitalier Pitié-Salpêtrière, 47-83 bd de l'hôpital A contributive result of open-lung biopsy improves survival in acute respiratory distress syndrome patients Do we need ARDS? Acute respiratory distress syndrome mimickers lacking common risk factors of the Berlin definition Etiologies, diagnostic work-up and outcomes of acute respiratory distress syndrome with no common risk factor: a prospective multicenter study Acute respiratory distress syndrome: the Berlin definition Diagnostic workup for ARDS patients Epidemiology, patterns of care, and mortality for patients with acute respiratory distress syndrome in intensive care units in 50 countries Anti-melanoma differentiation-associated protein 5-associated dermatomyositis: expanding the clinical spectrum Interstitial lung disease and anti-Jo-1 antibodies: difference between acute and gradual onset Dermato-pulmonary syndrome associated with MDA-5 antibodies A novel dermato-pulmonary syndrome associated with MDA-5 antibodies: report of 2 cases and review of the literature. Antisynthetase syndrome Clinical and serological aspects of patients with anti-Jo-1 antibodies-an evolving spectrum of disease manifestations Myositis specific autoantibodies: changing insights in pathophysiology and clinical associations Polymyositis, pulmonary fibrosis and autoantibodies to aminoacyl-tRNA synthetase enzymes Clinical manifestations and outcome of anti-PL7 positive patients with antisynthetase syndrome Sensitivity and specificity of anti-Jo-1 antibodies in autoimmune diseases with myositis Comparison of long-term outcome between anti-Jo1-and anti-PL7/PL12 positive patients with antisynthetase syndrome The mucocutaneous and systemic phenotype of dermatomyositis patients with antibodies to MDA5 (CADM-140): a retrospective study Clinical features and outcomes of interstitial lung disease in anti-Jo-1 positive antisynthetase syndrome Acute respiratory failure in critically ill patients with interstitial lung disease Idiopathic pulmonary fibrosis: predicting response to therapy and survival Idiopathic pulmonary fibrosis: a composite physiologic index derived from disease extent observed by computed tomography Comparison of the Berlin definition for acute respiratory distress syndrome with autopsy The role of open-lung biopsy in ARDS


id: cord-005511-h5d2v4ga
author: Ospina-Tascón, Gustavo A.
date: 2020-03-24
extension: .txt
mime: text/plain
words: 5223
sentence: 265
flesch: 43
cache: cache/cord-005511-h5d2v4ga.txt
txt: txt/cord-005511-h5d2v4ga.txt
title:
  Microcirculatory dysfunction and dead-space ventilation in early ARDS: a hypothesis-generating observational study

summary:
  Definitions, mechanisms, relevant outcomes, and clinical trial coordination Pulmonary dead-space fraction as a risk factor for death in the acute respiratory distress syndrome Pulmonary dead space fraction and pulmonary artery systolic pressure as early predictors of clinical outcome in acute lung injury Lung injury etiology and other factors influencing the relationship between deadspace fraction and mortality in ARDS Effects of positive end-expiratory pressure on gas exchange in dogs with normal and edematous lungs Functional heterogeneity of oxygen supply-consumption ratio in the heart Microvascular blood flow is altered in patients with sepsis Monitoring the microcirculation in the critically ill patient: current methods and future approaches Measuring microvascular blood flow in sepsis-a continuing challenge An early PEEP/FIO 2 trial identifies different degrees of lung injury in patients with acute respiratory distress syndrome Screening of ARDS patients using standardized ventilator settings: influence on enrollment in a clinical trial How large is the lung recruitability in early acute respiratory distress syndrome: a prospective case series of patients monitored by computed tomography Reversibility of lung collapse and hypoxemia in early acute respiratory distress syndrome Calculation of physiologic dead space: comparison of ventilator volumetric capnography to measurements by metabolic analyzer and volumetric CO 2 monitor How to evaluate the microcirculation: report of a round table conference Pathologic features and mechanisms of hypoxemia in adult respiratory distress syndrome Lung structure and function in different stages of severe adult respiratory distress syndrome Redistribution of pulmonary blood flow in the dog with PEEP ventilation The association between physiologic dead-space fraction and mortality in subjects with ARDS enrolled in a prospective multi-center clinical trial Lung inhomogeneity in patients with acute respiratory distress syndrome Microvascular perfusion as a target for fluid resuscitation in experimental circulatory shock Early bedside detection of pulmonary vascular occlusion during acute respiratory failure Vascular obstruction causes pulmonary hypertension in severe acute respiratory failure Alterations of the gas exchange apparatus in adult respiratory insufficiency associated with septicemia The pulmonary vascular lesions of the adult respiratory distress syndrome Relationship between capillary and systemic venous PO 2 during nonhypoxic and hypoxic ventilation Mechanisms of physiological dead space response to PEEP after acute oleic acid lung injury Assessment of dead-space ventilation in patients with acute respiratory distress syndrome: a prospective observational study Effect of anatomic shunt on physiologic deadspace-to-tidal volume ratio-a new equation Rationale of dead space measurement by volumetric capnography Effect of lung recruitment and titrated positive end-expiratory pressure (PEEP) vs low PEEP on mortality in patients with acute respiratory distress syndrome: a randomized clinical trial Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations We sought to evaluate the relationships between dynamic variations in V(D)/V(T) and extra-pulmonary microcirculatory blood flow detected at sublingual mucosa hypothesizing that an altered microcirculation, which is a generalized phenomenon during severe inflammatory conditions, could influence ventilation/perfusion mismatching manifested by increases in V(D)/V(T) fraction during early stages of ARDS.


id: cord-030130-n1x6gcn2
author: Hurtado, Daniel E.
date: 2020-08-06
extension: .txt
mime: text/plain
words: 5388
sentence: 222
flesch: 41
cache: cache/cord-030130-n1x6gcn2.txt
txt: txt/cord-030130-n1x6gcn2.txt
title:
  Progression of regional lung strain and heterogeneity in lung injury: assessing the evolution under spontaneous breathing and mechanical ventilation

summary:
  key: cord-030130-n1x6gcn2 authors: Hurtado, Daniel E.; Erranz, Benjamín; Lillo, Felipe; Sarabia-Vallejos, Mauricio; Iturrieta, Pablo; Morales, Felipe; Blaha, Katherine; Medina, Tania; Diaz, Franco; Cruces, Pablo title: Progression of regional lung strain and heterogeneity in lung injury: assessing the evolution under spontaneous breathing and mechanical ventilation date: 2020-08-06 journal: Changes in lung regional strain during spontaneous breathing were concurrent with the tomographic progression of the nonaerated-tissue compartment of the lung and a reduction of the normal-tissue compartment, in accordance with de-recruitment phenomenon, with collapse progression being higher in ventral regions of the lung.


id: cord-291459-m56dy8us
author: Hraiech, Sami
date: 2020-05-24
extension: .txt
mime: text/plain
words: 1154
sentence: 43
flesch: 43
cache: cache/cord-291459-m56dy8us.txt
txt: txt/cord-291459-m56dy8us.txt
title:
  Lack of viral clearance by the combination of hydroxychloroquine and azithromycin or lopinavir and ritonavir in SARS-CoV-2-related acute respiratory distress syndrome

summary:
  Although a positive PCR is not synonymous with active viral development, these results highlight the fact that neither of the treatments was able to achieve a rapid viral clearance in ARDS patients, as it has been suggested in one report on non-severe patients [4] . Groups were comparable, except for a higher severity at admission in control patients, who were more frequently transferred to the ICU only when requiring MV, because of the massive influx of patients in this region of France.


id: cord-279440-0mn5b0vv
author: Diehl, J-L
title: Response to Damiani and colleagues
date: 2020-10-14
extension: .txt
mime: text/plain
words: 882
sentence: 35
flesch: 37
cache: cache/cord-279440-0mn5b0vv.txt
txt: txt/cord-279440-0mn5b0vv.txt
summary:
  Ideally, such prospective studies should include COVID-19 ARDS patients and non-COVID-19 ARDS patients as a control group. One important point is that the very vast majority of studies in COVID-19 ARDS patients used, by convenience, ventilatory ratio (VR) as a marker of impaired ventilatory efficacy, as mentioned in Damiani's comment, rather than dead space measurements.


id: cord-004092-wb150n8w
author: Nieman, Gary F.
date: 2020-01-06
extension: .txt
mime: text/plain
words: 8073
sentence: 320
flesch: 43
cache: cache/cord-004092-wb150n8w.txt
txt: txt/cord-004092-wb150n8w.txt
title:
  Prevention and treatment of acute lung injury with time-controlled adaptive ventilation: physiologically informed modification of airway pressure release ventilation

summary:
  Summary of the experimental evidence for the clinical practice guideline Looking beyond macroventilatory parameters and rethinking ventilator-induced lung injury Airway pressure release ventilation reduces conducting airway micro-strain in lung injury Visualizing the propagation of acute lung injury Does regional lung strain correlate with regional inflammation in acute respiratory distress syndrome during nonprotective ventilation? An experimental porcine study Stress distribution in lungs: a model of pulmonary elasticity Alterations of mechanical properties and morphology in excised rabbit lungs rinsed with a detergent Physiology in Medicine: understanding dynamic alveolar physiology to minimize ventilator-induced lung injury Alveolar derecruitment and collapse induration as crucial mechanisms in lung injury and fibrosis Alveolitis and collapse in the pathogenesis of pulmonary fibrosis Mechanical ventilation-associated lung fibrosis in acute respiratory distress syndrome: a significant contributor to poor outcome Opening pressures and atelectrauma in acute respiratory distress syndrome Does high PEEP prevent alveolar cycling? Effect of lung recruitment and titrated positive endexpiratory pressure (PEEP) vs low PEEP on mortality in patients with acute respiratory distress syndrome: a randomized clinical trial Alveolar instability (atelectrauma) is not identified by arterial oxygenation predisposing the development of an occult ventilatorinduced lung injury Effects of respiratory rate, plateau pressure, and positive end-expiratory pressure on PaO2 oscillations after saline lavage A fibre optic oxygen sensor that detects rapid PO2 changes under simulated conditions of cyclical atelectasis in vitro Unstable inflation causing injury: insight from prone position and paired CT scans Deterioration of regional lung strain and inflammation during early lung injury Tidal changes on CT and progression of ARDS Lung inhomogeneities and time course of ventilator-induced mechanical injuries Mechanical breath profile of airway pressure release ventilation: the effect on alveolar recruitment and microstrain in acute lung injury Effect of airway pressure release ventilation on dynamic alveolar heterogeneity Mechanisms of surface-tensioninduced epithelial cell damage in a model of pulmonary airway reopening The influence of non-equilibrium surfactant dynamics on the flow of a semi-infinite bubble in a rigid cylindrical capillary tube Biomechanics of liquid-epithelium interactions in pulmonary airways Tidal ventilation at low airway pressures can augment lung injury Airway closure in acute respiratory distress syndrome: an underestimated and misinterpreted phenomenon Alveolar volume-surface area relation in air-and saline-filled lungs fixed by vascular perfusion Influence of forced inflations on the creep of lungs and thorax in the dog Alveolar micromechanics in bleomycin-induced lung injury Lung inhomogeneity in patients with acute respiratory distress syndrome Micromechanics of alveolar edema Local strain distribution in real three-dimensional alveolar geometries Stress concentration around an atelectatic region: a finite element model Acute respiratory distress syndrome Never give the lung the opportunity to collapse Preemptive mechanical ventilation based on dynamic physiology in the alveolar microenvironment: novel considerations of time-dependent properties of the respiratory system Last Word on Viewpoint: looking beyond macroventilatory parameters and rethinking ventilator-induced lung injury Regional behavior of airspaces during positive pressure reduction assessed by synchrotron radiation computed tomography The effect of positive end-expiratory pressure on lung micromechanics assessed by synchrotron radiation computed tomography in an animal model of ARDS Dynamic mechanical interactions between neighboring airspaces determine cyclic opening and closure in injured lung Individual airway closure characterized in vivo by phase-contrast ct imaging in injured rabbit lung Ventilator-induced lung injury and lung mechanics Limiting ventilator-associated lung injury in a preterm porcine neonatal model Early application of airway pressure release ventilation may reduce mortality in high-risk trauma patients: a systematic review of observational trauma ARDS literature Alveolar leak develops by a rich-get-richer process in ventilatorinduced lung injury Lung tissue viscoelasticity: a mathematical framework and its molecular basis Lung parenchymal mechanics Lung parenchymal mechanics in health and disease Modeling the complex dynamics of derecruitment in the lung Respiratory mechanics in anesthetized paralyzed humans: effects of flow, volume, and time Differential susceptibility of diaphragm muscle fibers to neuromuscular transmission failure Lung mechanics.


id: cord-285130-tcnpskpy
author: Wang, Ke
date: 2020-03-30
extension: .txt
mime: text/plain
words: 2280
sentence: 139
flesch: 58
cache: cache/cord-285130-tcnpskpy.txt
txt: txt/cord-285130-tcnpskpy.txt
title:
  The experience of high-flow nasal cannula in hospitalized patients with 2019 novel coronavirus-infected pneumonia in two hospitals of Chongqing, China

summary:
  In our study, we found that the number of HFNC patients were much higher than NIV patients when the HFNC or NIV was used as an initial oxygen support. A previous study reported that 38% of HFNC patients required intubation [13] .


id: cord-025170-dtbm4ue1
author: Malbrain, Manu L. N. G.
date: 2020-05-24
extension: .txt
mime: text/plain
words: 9185
sentence: 361
flesch: 34
cache: cache/cord-025170-dtbm4ue1.txt
txt: txt/cord-025170-dtbm4ue1.txt
title:
  Intravenous fluid therapy in the perioperative and critical care setting: Executive summary of the International Fluid Academy (IFA)

summary:
  Hydroxyethyl starch 130/0.42 versus Ringer's acetate in severe sepsis Intravenous balanced solutions: from physiology to clinical evidence It is time to consider the four D's of fluid management Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults Resuscitation fluids National Institute for H, Care Excellence Guideline Development G. Intravenous fluid therapy for adults in hospital: summary of NICE guidance Intravenous fluid therapy for hospitalized and critically ill children: rationale, available drugs and possible side effects Principles of fluid management and stewardship in septic shock: it is time to consider the four D's and the four phases of fluid therapy Effect of isotonic versus hypotonic maintenance fluid therapy on urine output, fluid balance, and electrolyte homeostasis: a crossover study in fasting adult volunteers Maintenance intravenous fluids in acutely ill patients Maintenance fluid therapy and fluid creep impose more significant fluid, sodium, and chloride burdens than resuscitation fluids in critically ill patients: a retrospective study in a tertiary mixed ICU population Normal saline to dilute parenteral drugs and to keep catheters open is a major and preventable source of hypernatremia acquired in the intensive care unit Mortality after fluid bolus in African children with severe infection Unintended consequences: fluid resuscitation worsens shock in an ovine model of endotoxemia Fluid overload, de-resuscitation, and outcomes in critically ill or injured patients: a systematic review with suggestions for clinical practice Independent and dependent variables of acid-base control Stewartìs textbook of acid-base Lulucom Electrolyte shifts across the artificial lung in patients on extracorporeal membrane oxygenation: interdependence between partial pressure of carbon dioxide and strong ion difference Crystalloid strong ion difference determines metabolic acid-base change during in vitro hemodilution Effects of intravenous solutions on acid-base equilibrium: from crystalloids to colloids and blood components In vivo conditioning of acid-base equilibrium by crystalloid solutions: an experimental study on pigs Resuscitation fluids are used to correct an intravascular volume deficit or acute hypovolemia; replacement solutions are prescribed to correct existing or developing deficits that cannot be compensated by oral intake alone


id: cord-004059-furt6xcn
author: Hraiech, Sami
date: 2019-12-23
extension: .txt
mime: text/plain
words: 3392
sentence: 147
flesch: 38
cache: cache/cord-004059-furt6xcn.txt
txt: txt/cord-004059-furt6xcn.txt
title:
  Herpes simplex virus and Cytomegalovirus reactivation among severe ARDS patients under veno-venous ECMO

summary:
  The role of Herpesviridae pre-emptive treatment among ICU patients has been recently evaluated in a randomized controlled trial (RCT) (NCT 02152358). The coefficient designates the number of days by which the different endpoints are affected Data are presented as median and interquartile range or absolute value and percentage a p < 0.05 compared with non-reactivation group Until today, no data have been published concerning Herpesviridae reactivation in ICU patients under VV ECMO for severe ARDS.


id: cord-026659-mhe6q1ce
author: Sanaie, Sarvin
date: 2020-06-12
extension: .txt
mime: text/plain
words: 3922
sentence: 157
flesch: 48
cache: cache/cord-026659-mhe6q1ce.txt
txt: txt/cord-026659-mhe6q1ce.txt
title:
  A comparison of nasogastric tube insertion by SORT maneuver (sniffing position, NGT orientation, contralateral rotation, and twisting movement) versus neck flexion lateral pressure in critically ill patients admitted to ICU: a prospective randomized clinical trial

summary:
  Considering feasibility and cost effectiveness, there is growing interest in NGT insertion techniques that are not device-based. Finally, binary and multinomial logistic regressions were applied to examine the association of categorical and binary outcomes with NGT insertion techniques, respectively, after adjusting for confounders.


id: cord-322773-zimkzbr1
author: Beloncle, François M.
title: Recruitability and effect of PEEP in SARS-Cov-2-associated acute respiratory distress syndrome
date: 2020-05-12
extension: .txt
mime: text/plain
words: 3927
sentence: 169
flesch: 49
cache: cache/cord-322773-zimkzbr1.txt
txt: txt/cord-322773-zimkzbr1.txt
summary:
  The lung volume predicted by the compliance at low PEEP represents the minimum predicted change in lung volume corresponding to the change in pressure between the 2 PEEP levels (i.e. the change in lung volume if no recruitment occurs) and is equal to the product of C RS at PEEP 5 cmH 2 O (or above AOP) and PEEP change (i.e. 10 cmH 2 O or 15-AOP). Lung recruitment induced by high PEEP and detection of airway closure were assessed as previously described [7, 8] .


id: cord-029136-mbqncen1
author: De Pascale, Gennaro
title: Pharmacokinetics of high-dose tigecycline in critically ill patients with severe infections
date: 2020-07-13
extension: .txt
mime: text/plain
words: 3994
sentence: 145
flesch: 39
cache: cache/cord-029136-mbqncen1.txt
txt: txt/cord-029136-mbqncen1.txt
summary:
  Stock solution of TGC and the internal standard (IS), propranolol hydrochloride, were prepared by dissolving accurately weighed amounts of each compound in MeOH to obtain a final concentration of 0.1 mcg/mL. Calibration standards were prepared by diluting stock solutions of TGC in drug-free human plasma to yield TGC concentrations of 5000, 2500, 1250, 625, 312.5, 156.25, 78.125, 39.1, 19.5 and 9.76 ng/mL. Tigecycline liquid/liquid extraction from plasma samples (see Additional file 1). Figure 1 shows the mean ± SD time-concentration profile at different time points of plasma tigecycline concentrations, compared with most frequently observed MIC values (0.12-0.25-0.5 mcg/mL).


id: cord-025615-xaehtmjf
author: Roesthuis, L. H.
date: 2020-05-29
extension: .txt
mime: text/plain
words: 4540
sentence: 218
flesch: 41
cache: cache/cord-025615-xaehtmjf.txt
txt: txt/cord-025615-xaehtmjf.txt
title:
  Recruitment pattern of the diaphragm and extradiaphragmatic inspiratory muscles in response to different levels of pressure support

summary:
  Therefore, it is interesting to investigate the role of surrogate markers for respiratory dive, such as extradiaphragmatic inspiratory muscle activity. Diaphragm and extradiaphragmatic inspiratory muscle activity increased in response to lower PS levels (36 ± 6% increase for the diaphragm, 30 ± 6% parasternal intercostals, 41 ± 6% scalene, 40 ± 8% sternocleidomastoid, 43 ± 6% alae nasi and 30 ± 6% genioglossus).


id: cord-306315-vt2e0crh
author: Elabbadi, Alexandre
date: 2020-09-14
extension: .txt
mime: text/plain
words: 4743
sentence: 185
flesch: 30
cache: cache/cord-306315-vt2e0crh.txt
txt: txt/cord-306315-vt2e0crh.txt
title:
  Respiratory virus-associated infections in HIV-infected adults admitted to the intensive care unit for acute respiratory failure: a 6-year bicenter retrospective study (HIV-VIR study)

summary:
  Medicine (Baltimore) Respiratory viruses in HIV-infected patients with suspected respiratory opportunistic infection Outcome of critically ill human immunodeficiency virus-infected patients in the era of highly active antiretroviral therapy Survival of HIV-infected patients in the intensive care unit in the era of highly active antiretroviral therapy Etiology of pulmonary infections in human immunodeficiency virus-infected inpatients using sputum multiplex real-time polymerase chain reaction Impact of HIV infection and smoking on lung immunity and related disorders Cigarette smoke and HIV synergistically affect lung pathology in cynomolgus macaques A prospective, observational cohort study of the seasonal dynamics of airway pathogens in the aetiology of exacerbations in COPD Cigarette smoke decreases innate responses of epithelial cells to rhinovirus infection Cigarette smoke attenuates the RIG-I-initiated innate antiviral response to influenza infection in two murine models Cigarette smoke suppresses TLR-7 stimulation in response to virus infection in plasmacytoid dendritic cells Recording of influenza-like illness in UK primary care 1995-2013: cohort study Incidence and risk factors for influenza-like-illness in the UK: online surveillance using Flusurvey Respiratory viruses in young South African children with acute lower respiratory infections and interactions with HIV Etiology and epidemiology of viral pneumonia among hospitalized children in rural Mozambique: a malaria endemic area with high prevalence of human immunodeficiency virus Pandemic (H1N1) 2009 influenza virus seroconversion rates in HIV-infected individuals Incidence of respiratory viruses in patients with community-acquired pneumonia admitted to the intensive care unit: results from the Severe Influenza Pneumonia Surveillance (SIPS) project Clinical epidemiology of bocavirus, rhinovirus, two polyomaviruses and four coronaviruses in HIV-infected and HIV-uninfected South African children Respiratory virus detection in immunocompromised patients with FilmArray respiratory panel compared to conventional methods Virological diagnosis in community-acquired pneumonia in immunocompromised patients Prolonged shedding of rhinovirus and re-infection in adults with respiratory tract illness Chronic rhinoviral infection in lung transplant recipients Persistent human rhinovirus type C infection of the lower respiratory tract in a pediatric cord blood transplant recipient Persistent rhinovirus infection in pediatric hematopoietic stem cell transplant recipients with impaired cellular immunity Viral infection in community-acquired pneumonia: a systematic review and meta-analysis Coinfection with Streptococcus pneumoniae negatively modulates the size and composition of the ongoing influenza-specific CD8 + T cell response Role of tissue protection in lethal respiratory viral-bacterial coinfection Influenza virus primes mice for pneumonia from Staphylococcus aureus Pneumocystis infection enhances antibodymediated resistance to a subsequent influenza infection Diagnosis and management of respiratory viruses in critically ill adult patients: an international survey of knowledge and practice among intensivists Diagnostic value of microscopic examination of Gram-stained sputum and sputum cultures in patients with bacteremic pneumococcal pneumonia Comparison of sputum and nasopharyngeal swabs for detection of respiratory viruses Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations None. GV had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis, including and especially any adverse effects. Additional information on Material and methods, Table S1 (Panels of mPCR kits used in the two participating ICUs over the 6-year study period), Table S2 (Microbiological investigations performed in 123 HIV-infected patients admitted to the ICU for acute respiratory failure, according to the diagnosis of respiratory virus-associated infection), Table S3 (Baseline characteristics, behavior during ICU stay, and outcome of 123 HIV-infected patients admitted to the ICU for acute respiratory failure, according to the diagnosis of respiratory virus-associated infection), Table S4 (Multivariate analysis of the risk factors for death at Day-28 in 123 HIV-infected patients admitted to the ICU for acute respiratory failure), Figure S1 (Distribution of the microbiological documentations in 123 HIVinfected patients admitted to the ICU for acute respiratory failure), Figure S2 Admissions to intensive care unit of HIV-infected patients in the era of highly active antiretroviral therapy: etiology and prognostic factors Etiologies and outcome of acute respiratory failure in HIVinfected patients Temporal trends in critical events complicating HIV infection: 1999-2010 multicentre cohort study in France Survival for patients with HIV admitted to the ICU continues to improve in the current era of combination antiretroviral therapy Pulmonary infections in HIV-infected patients: an update in the 21st century HIV infection and risk for incident pulmonary diseases in the combination antiretroviral therapy era Epidemiology and clinical outcome of virus-positive respiratory samples in ventilated patients: a prospective cohort study Respiratory viruses in invasively ventilated critically ill patients-a prospective multicenter observational study Viral-bacterial coinfection affects the presentation and alters the prognosis of severe community-acquired pneumonia Lower respiratory tract virus findings in mechanically ventilated patients with severe community-acquired pneumonia Impact of respiratory viruses in hospital-acquired pneumonia in the intensive care unit: a single-center retrospective study Virus infection in exacerbations of chronic obstructive pulmonary disease requiring ventilation Procalcitonin algorithm to guide initial antibiotic therapy in acute exacerbations of COPD admitted to the ICU: a randomized multicenter study Epidemiology of respiratory viruses in patients hospitalized with near-fatal asthma, acute exacerbations of asthma, or chronic obstructive pulmonary disease Community surveillance of respiratory viruses among families in the utah better identification of germs-longitudinal viral epidemiology (BIG-LoVE) study Community-acquired pneumonia requiring hospitalization among U.S. adults Clinical significance of upper airway virus detection in critically ill hematology patients Management of respiratory viral infections in hematopoietic cell transplant recipients and patients with hematologic malignancies Prospective etiological investigation of community-acquired pulmonary infections in hospitalized people living with HIV.


id: cord-346062-q0trgj12
author: Robert, René
title: Ethical dilemmas due to the Covid-19 pandemic
date: 2020-06-17
extension: .txt
mime: text/plain
words: 5719
sentence: 220
flesch: 40
cache: cache/cord-346062-q0trgj12.txt
txt: txt/cord-346062-q0trgj12.txt
summary:
  Indeed, in addition to the elements linked to the lack of available beds, several factors in the decisionmaking process were sources of concern: reduction of the minimum time necessary to make such occasionally life-or-death decisions, decrease due to containment measures in the essential time to be spent with relatives and pressure from the continuous flow of arriving ICU patients. As another application of the societal concept, it has been proposed to prioritize for ICU care the caregivers who have become critically ill, not due to their intrinsic quality or for so as to reward them, but rather for the possibility, once they are cured, of being returning to the operational caregiving circuit


id: cord-345591-zwh1xj5u
author: Al-Dorzi, Hasan M.
date: 2016-10-24
extension: .txt
mime: text/plain
words: 5885
sentence: 277
flesch: 46
cache: cache/cord-345591-zwh1xj5u.txt
txt: txt/cord-345591-zwh1xj5u.txt
title:
  The critical care response to a hospital outbreak of Middle East respiratory syndrome coronavirus (MERS-CoV) infection: an observational study

summary:
  The hospital mortality of ICU MERS patients was 63.4 % (0 % for the HCWs). According to the IDEP, one unit (Unit A) was designated as the primary receiving unit for MERS patients, because of its geographic location being away from main hospital traffic and because 7 of its 8 rooms were negative-pressure airborne infection isolation rooms (AIIR).


id: cord-316647-jj8anf5g
author: Shang, You
date: 2020-06-06
extension: .txt
mime: text/plain
words: 13606
sentence: 559
flesch: 35
cache: cache/cord-316647-jj8anf5g.txt
txt: txt/cord-316647-jj8anf5g.txt
title:
  Management of critically ill patients with COVID-19 in ICU: statement from front-line intensive care experts in Wuhan, China

summary:
  However, considering the suggestion that restrictive fluid volume management strategy should be adopted for COVID-19 patients complicated by ARDS based on the premise of sufficient tissue perfusion, we suggest CRRT initiation in severe patients within 24 h when they show rank 2 AKI under KDIGO criteria or accompanied with cytokine storm syndrome. There are still no targeted therapies for COVID-19 patients.


id: cord-325461-q8igdvq4
author: Ryan, Donal
title: Pulmonary vascular dysfunction in ARDS
date: 2014-08-22
extension: .txt
mime: text/plain
words: 6631
sentence: 274
flesch: 37
cache: cache/cord-325461-q8igdvq4.txt
txt: txt/cord-325461-q8igdvq4.txt
summary:
  We know from studies of major pulmonary embolism, that a normal right ventricle cannot acutely generate pulmonary pressures greater than 40 mmHg (mean) and quickly fails in this clinical context [64] . Pulmonary arterial pressure, pulmonary vascular resistance and transpulmonary gradient (TPG) depend not alone on the intrinsic properties of the pulmonary vascular bed but are also strongly influenced by cardiac output, airway pressures and lung volumes.


id: cord-305582-3hmsknon
author: Li, Lei
title: Therapeutic strategies for critically ill patients with COVID-19
date: 2020-04-20
extension: .txt
mime: text/plain
words: 6194
sentence: 250
flesch: 35
cache: cache/cord-305582-3hmsknon.txt
txt: txt/cord-305582-3hmsknon.txt
summary:
  Available drug options that come from the clinical experience of treating SARS, MERS and other previous influenza virus have been used for the treatment of COVID-19 patients. Considering the high incidence of bacterial infection for critically ill patients with COVID-19, it is essential to test the kinetics of procalcitonin (PCT) and C-reaction protein (CRP) in COVID-19 patients for timely diagnosis and intervention of bacterial infection.


id: cord-014538-6a2pviol
author: Kamilia, Chtara
title: Proceedings of Réanimation 2017, the French Intensive Care Society International Congress
date: 2017-01-10
extension: .txt
mime: text/plain
words: 61107
sentence: 2899
flesch: 45
cache: cache/cord-014538-6a2pviol.txt
txt: txt/cord-014538-6a2pviol.txt
summary:
  We included ICU patients admitted for acute hypoxemic respiratory failure from a previous prospective trial [1] in whom FiO 2 was measured under oxygen mask using a portable oxygen analyzer. Introduction Relative adrenal insufficiency (RAI) is common in ICU patients, particularly during septic shock (1).


id: cord-335975-m6lkrehi
title: Proceedings of Réanimation 2018, the French Intensive Care Society International Congress
date: 2018-02-05
extension: .txt
mime: text/plain
words: 89523
sentence: 4736
flesch: 50
cache: cache/cord-335975-m6lkrehi.txt
txt: txt/cord-335975-m6lkrehi.txt
summary:
  The aim of this study was to compare the outcome of ICU patients having received carbapenems to those having received a carbapenem-sparing agent (CSA). Conclusion: Severe hypoxemia, independently from ARDS, worsens the prognosis of ICU patients.


id: cord-355038-o2hr5mox
title: Proceedings of Réanimation 2020, the French Intensive Care Society International Congress
date: 2020-02-11
extension: .txt
mime: text/plain
words: 102622
sentence: 5848
flesch: 49
cache: cache/cord-355038-o2hr5mox.txt
txt: txt/cord-355038-o2hr5mox.txt
summary:
  No significant difference between the NE and AVP groups for lactate clearance between H0 and H6 (25.6 [− 7.31 to 35.34]% vs 47.84 [13.42-82.73 ]%, p = 0.686). D: blood frequency of MAIT cells in patients with pneumonia compared with healthy controls (as % of total T cells)


# ent

id: cord-014538-6a2pviol
sid: 2424
eid: 6
type: ORG
entity:
  hopital avicenne institut für anästhesiologische pathophysiologie und verfahrensentwicklung département de réanimation médicale et de médecine hyperbare


