id	sid	tid	token	lemma	pos
app-558	1	1	86	86	NUM
app-558	1	2	ann	ann	PROPN
app-558	1	3	.	.	PUNCT
app-558	1	4	psychophysiol	psychophysiol	PROPN
app-558	1	5	.	.	PUNCT
app-558	2	1	issn	issn	PROPN
app-558	2	2	2412	2412	NUM
app-558	2	3	-	-	SYM
app-558	2	4	3188	3188	NUM
app-558	2	5	(	(	PUNCT
app-558	2	6	online	online	NOUN
app-558	2	7	)	)	PUNCT
app-558	2	8	|	|	ADV
app-558	2	9	2410	2410	NUM
app-558	2	10	-	-	SYM
app-558	2	11	1354	1354	NUM
app-558	2	12	(	(	PUNCT
app-558	2	13	print	print	NOUN
app-558	2	14	)	)	PUNCT
app-558	2	15	app|	app|	NOUN
app-558	2	16	published	publish	VERB
app-558	2	17	by	by	ADP
app-558	2	18	aeirc|	aeirc|	ADP
app-558	2	19	https://doi.org/10.29052/2412-3188.v8.i2.2021.86-95	https://doi.org/10.29052/2412-3188.v8.i2.2021.86-95	DET
app-558	2	20	original	original	ADJ
app-558	2	21	article	article	NOUN
app-558	2	22	the	the	DET
app-558	2	23	identification	identification	NOUN
app-558	2	24	of	of	ADP
app-558	2	25	sialuria	sialuria	PROPN
app-558	2	26	with	with	ADP
app-558	2	27	different	different	ADJ
app-558	2	28	degrees	degree	NOUN
app-558	2	29	of	of	ADP
app-558	2	30	intellectual	intellectual	ADJ
app-558	2	31	disabilities	disability	NOUN
app-558	2	32	in	in	ADP
app-558	2	33	children	child	NOUN
app-558	2	34	and	and	CCONJ
app-558	2	35	adolescents	adolescents	PROPN
app-558	2	36	hina	hina	PROPN
app-558	2	37	ishtiaq1	ishtiaq1	PROPN
app-558	2	38	,	,	PUNCT
app-558	2	39	sonia	sonia	PROPN
app-558	2	40	siddiqui2	siddiqui2	PROPN
app-558	2	41	,	,	PUNCT
app-558	2	42	rukhsana	rukhsana	PROPN
app-558	2	43	nawaz3	nawaz3	PROPN
app-558	2	44	,	,	PUNCT
app-558	2	45	muhammad	muhammad	PROPN
app-558	2	46	ashraf	ashraf	PROPN
app-558	2	47	hussain4	hussain4	PROPN
app-558	2	48	,	,	PUNCT
app-558	2	49	fauzia	fauzia	ADJ
app-558	2	50	imtiaz2	imtiaz2	PROPN
app-558	2	51	&	&	CCONJ
app-558	2	52	zeba	zeba	PROPN
app-558	2	53	haque2	haque2	PROPN
app-558	3	1	1department	1department	NUM
app-558	3	2	of	of	ADP
app-558	3	3	neuroscience	neuroscience	NOUN
app-558	3	4	,	,	PUNCT
app-558	3	5	dr	dr	PROPN
app-558	3	6	.	.	PROPN
app-558	3	7	panjwani	panjwani	PROPN
app-558	3	8	center	center	PROPN
app-558	3	9	for	for	ADP
app-558	3	10	molecular	molecular	ADJ
app-558	3	11	medicine	medicine	NOUN
app-558	3	12	and	and	CCONJ
app-558	3	13	drug	drug	NOUN
app-558	3	14	research	research	NOUN
app-558	3	15	,	,	PUNCT
app-558	3	16	international	international	ADJ
app-558	3	17	center	center	NOUN
app-558	3	18	for	for	ADP
app-558	3	19	chemical	chemical	NOUN
app-558	3	20	and	and	CCONJ
app-558	3	21	biological	biological	ADJ
app-558	3	22	sciences	science	NOUN
app-558	3	23	,	,	PUNCT
app-558	3	24	university	university	PROPN
app-558	3	25	of	of	ADP
app-558	3	26	karachi	karachi	PROPN
app-558	3	27	,	,	PUNCT
app-558	3	28	karachi	karachi	PROPN
app-558	3	29	-	-	PUNCT
app-558	3	30	pakistan	pakistan	PROPN
app-558	3	31	.	.	PUNCT
app-558	4	1	2department	2department	NUM
app-558	4	2	of	of	ADP
app-558	4	3	biochemistry	biochemistry	NOUN
app-558	4	4	,	,	PUNCT
app-558	4	5	dow	dow	PROPN
app-558	4	6	university	university	PROPN
app-558	4	7	of	of	ADP
app-558	4	8	health	health	PROPN
app-558	4	9	sciences	sciences	PROPN
app-558	4	10	,	,	PUNCT
app-558	4	11	karachi	karachi	PROPN
app-558	4	12	-	-	PUNCT
app-558	4	13	pakistan	pakistan	PROPN
app-558	4	14	.	.	PUNCT
app-558	5	1	3department	3department	NUM
app-558	5	2	of	of	ADP
app-558	5	3	psychology	psychology	NOUN
app-558	5	4	,	,	PUNCT
app-558	5	5	college	college	NOUN
app-558	5	6	of	of	ADP
app-558	5	7	humanities	humanity	NOUN
app-558	5	8	and	and	CCONJ
app-558	5	9	social	social	ADJ
app-558	5	10	sciences	science	NOUN
app-558	5	11	,	,	PUNCT
app-558	5	12	university	university	PROPN
app-558	5	13	of	of	ADP
app-558	5	14	uae	uae	PROPN
app-558	5	15	,	,	PUNCT
app-558	5	16	al	al	PROPN
app-558	5	17	-	-	PUNCT
app-558	5	18	ain	ain	PROPN
app-558	5	19	,	,	PUNCT
app-558	5	20	uae	uae	PROPN
app-558	5	21	.	.	PUNCT
app-558	6	1	4combined	4combined	NUM
app-558	6	2	military	military	ADJ
app-558	6	3	hospital	hospital	NOUN
app-558	6	4	,	,	PUNCT
app-558	6	5	national	national	ADJ
app-558	6	6	university	university	PROPN
app-558	6	7	of	of	ADP
app-558	6	8	medical	medical	ADJ
app-558	6	9	sciences	science	NOUN
app-558	6	10	,	,	PUNCT
app-558	6	11	zhob	zhob	VERB
app-558	6	12	,	,	PUNCT
app-558	6	13	baluchistanpakistan	baluchistanpakistan	ADJ
app-558	6	14	.	.	PUNCT
app-558	7	1	abstract	abstract	ADJ
app-558	7	2	background	background	NOUN
app-558	7	3	:	:	PUNCT
app-558	7	4	single	single	ADJ
app-558	7	5	nucleotide	nucleotide	ADJ
app-558	7	6	polymorphism	polymorphism	NOUN
app-558	7	7	/	/	SYM
app-558	7	8	mutation	mutation	NOUN
app-558	7	9	in	in	ADP
app-558	7	10	the	the	DET
app-558	7	11	r263l	r263l	PROPN
app-558	7	12	region	region	NOUN
app-558	7	13	of	of	ADP
app-558	7	14	the	the	DET
app-558	7	15	allosteric	allosteric	ADJ
app-558	7	16	site	site	NOUN
app-558	7	17	of	of	ADP
app-558	7	18	the	the	DET
app-558	7	19	gne	gne	PROPN
app-558	7	20	gene	gene	NOUN
app-558	7	21	produces	produce	VERB
app-558	7	22	a	a	DET
app-558	7	23	phenotype	phenotype	NOUN
app-558	7	24	with	with	ADP
app-558	7	25	an	an	DET
app-558	7	26	overproduction	overproduction	NOUN
app-558	7	27	of	of	ADP
app-558	7	28	intracellular	intracellular	ADJ
app-558	7	29	levels	level	NOUN
app-558	7	30	of	of	ADP
app-558	7	31	sialic	sialic	ADJ
app-558	7	32	acid	acid	NOUN
app-558	7	33	and	and	CCONJ
app-558	7	34	causes	cause	VERB
app-558	7	35	sialuria	sialuria	PRON
app-558	7	36	.	.	PUNCT
app-558	8	1	in	in	ADP
app-558	8	2	sialuria	sialuria	PROPN
app-558	8	3	,	,	PUNCT
app-558	8	4	a	a	DET
app-558	8	5	defective	defective	ADJ
app-558	8	6	gne	gne	PROPN
app-558	8	7	gene	gene	NOUN
app-558	8	8	,	,	PUNCT
app-558	8	9	synthesized	synthesize	VERB
app-558	8	10	with	with	ADP
app-558	8	11	lost	lose	VERB
app-558	8	12	feedback	feedback	NOUN
app-558	8	13	inhibition	inhibition	NOUN
app-558	8	14	mechanism	mechanism	NOUN
app-558	8	15	,	,	PUNCT
app-558	8	16	produces	produce	VERB
app-558	8	17	many	many	ADJ
app-558	8	18	developmental	developmental	ADJ
app-558	8	19	delays	delay	NOUN
app-558	8	20	and	and	CCONJ
app-558	8	21	varying	vary	VERB
app-558	8	22	degrees	degree	NOUN
app-558	8	23	of	of	ADP
app-558	8	24	intellectual	intellectual	ADJ
app-558	8	25	disabilities	disability	NOUN
app-558	8	26	in	in	ADP
app-558	8	27	children	child	NOUN
app-558	8	28	and	and	CCONJ
app-558	8	29	adolescents	adolescent	NOUN
app-558	8	30	.	.	PUNCT
app-558	9	1	several	several	ADJ
app-558	9	2	mutations	mutation	NOUN
app-558	9	3	in	in	ADP
app-558	9	4	the	the	DET
app-558	9	5	epimerase	epimerase	NOUN
app-558	9	6	and	and	CCONJ
app-558	9	7	kinase	kinase	PROPN
app-558	9	8	domains	domain	NOUN
app-558	9	9	exist	exist	VERB
app-558	9	10	that	that	PRON
app-558	9	11	cause	cause	VERB
app-558	9	12	difficulty	difficulty	NOUN
app-558	9	13	in	in	ADP
app-558	9	14	getting	get	VERB
app-558	9	15	a	a	DET
app-558	9	16	precise	precise	ADJ
app-558	9	17	and	and	CCONJ
app-558	9	18	exact	exact	ADJ
app-558	9	19	effect	effect	NOUN
app-558	9	20	of	of	ADP
app-558	9	21	the	the	DET
app-558	9	22	gne	gne	PROPN
app-558	9	23	gene	gene	NOUN
app-558	9	24	on	on	ADP
app-558	9	25	the	the	DET
app-558	9	26	disease	disease	NOUN
app-558	9	27	severity	severity	NOUN
app-558	9	28	and	and	CCONJ
app-558	9	29	sialic	sialic	ADJ
app-558	9	30	acid	acid	NOUN
app-558	9	31	levels	level	NOUN
app-558	9	32	.	.	PUNCT
app-558	10	1	this	this	PRON
app-558	10	2	is	be	AUX
app-558	10	3	the	the	DET
app-558	10	4	first	first	ADJ
app-558	10	5	study	study	NOUN
app-558	10	6	investigating	investigate	VERB
app-558	10	7	the	the	DET
app-558	10	8	molecular	molecular	ADJ
app-558	10	9	basis	basis	NOUN
app-558	10	10	of	of	ADP
app-558	10	11	neuronal	neuronal	ADJ
app-558	10	12	disorders	disorder	NOUN
app-558	10	13	exhibiting	exhibit	VERB
app-558	10	14	sialuria	sialuria	ADJ
app-558	10	15	in	in	ADP
app-558	10	16	pakistani	pakistani	ADJ
app-558	10	17	children/	children/	NUM
app-558	10	18	adolescents	adolescent	NOUN
app-558	10	19	.	.	PUNCT
app-558	11	1	methodology	methodology	NOUN
app-558	11	2	:	:	PUNCT
app-558	12	1	the	the	DET
app-558	12	2	current	current	ADJ
app-558	12	3	study	study	NOUN
app-558	12	4	quantified	quantify	VERB
app-558	12	5	the	the	DET
app-558	12	6	mrna	mrna	NOUN
app-558	12	7	expression	expression	NOUN
app-558	12	8	of	of	ADP
app-558	12	9	the	the	DET
app-558	12	10	gne	gne	PROPN
app-558	12	11	gene	gene	NOUN
app-558	12	12	and	and	CCONJ
app-558	12	13	urinary	urinary	ADJ
app-558	12	14	sialic	sialic	ADJ
app-558	12	15	acid	acid	NOUN
app-558	12	16	concentration	concentration	NOUN
app-558	12	17	by	by	ADP
app-558	12	18	realtime	realtime	NOUN
app-558	12	19	-	-	PUNCT
app-558	12	20	qrt	qrt	ADJ
app-558	12	21	-	-	PUNCT
app-558	12	22	pcr	pcr	ADJ
app-558	12	23	and	and	CCONJ
app-558	12	24	fluorimetric	fluorimetric	ADJ
app-558	12	25	assays	assay	NOUN
app-558	12	26	,	,	PUNCT
app-558	12	27	respectively	respectively	ADV
app-558	12	28	.	.	PUNCT
app-558	13	1	the	the	DET
app-558	13	2	correlation	correlation	NOUN
app-558	13	3	between	between	ADP
app-558	13	4	relative	relative	ADJ
app-558	13	5	mrna	mrna	PROPN
app-558	13	6	and	and	CCONJ
app-558	13	7	urinary	urinary	ADJ
app-558	13	8	sialic	sialic	ADJ
app-558	13	9	acid	acid	NOUN
app-558	13	10	levels	level	NOUN
app-558	13	11	was	be	AUX
app-558	13	12	evaluated	evaluate	VERB
app-558	13	13	by	by	ADP
app-558	13	14	using	use	VERB
app-558	13	15	pearson	pearson	PROPN
app-558	13	16	bivariate	bivariate	ADJ
app-558	13	17	correlations	correlation	NOUN
app-558	13	18	.	.	PUNCT
app-558	14	1	results	result	NOUN
app-558	14	2	:	:	PUNCT
app-558	14	3	the	the	DET
app-558	14	4	data	datum	NOUN
app-558	14	5	show	show	VERB
app-558	14	6	that	that	SCONJ
app-558	14	7	severely	severely	ADV
app-558	14	8	intellectually	intellectually	ADV
app-558	14	9	disabled	disabled	ADJ
app-558	14	10	(	(	PUNCT
app-558	14	11	i.d	i.d	PROPN
app-558	14	12	.	.	PROPN
app-558	14	13	)	)	PUNCT
app-558	15	1	patients	patient	NOUN
app-558	15	2	showed	show	VERB
app-558	15	3	significantly	significantly	ADV
app-558	15	4	reduced	reduce	VERB
app-558	15	5	mrna	mrna	PROPN
app-558	15	6	expression	expression	NOUN
app-558	15	7	levels	level	NOUN
app-558	15	8	of	of	ADP
app-558	15	9	the	the	DET
app-558	15	10	gne	gne	PROPN
app-558	15	11	gene	gene	NOUN
app-558	15	12	compared	compare	VERB
app-558	15	13	to	to	ADP
app-558	15	14	controls	control	NOUN
app-558	15	15	.	.	PUNCT
app-558	16	1	the	the	DET
app-558	16	2	concentrations	concentration	NOUN
app-558	16	3	of	of	ADP
app-558	16	4	free	free	ADJ
app-558	16	5	sialic	sialic	ADJ
app-558	16	6	acid	acid	NOUN
app-558	16	7	in	in	ADP
app-558	16	8	urine	urine	NOUN
app-558	16	9	were	be	AUX
app-558	16	10	significantly	significantly	ADV
app-558	16	11	reduced	reduce	VERB
app-558	16	12	in	in	ADP
app-558	16	13	severe	severe	ADJ
app-558	16	14	i.d	i.d	PROPN
app-558	16	15	.	.	PROPN
app-558	17	1	patients	patient	NOUN
app-558	17	2	compared	compare	VERB
app-558	17	3	to	to	ADP
app-558	17	4	controls	control	NOUN
app-558	17	5	.	.	PUNCT
app-558	18	1	whereas	whereas	SCONJ
app-558	18	2	patients	patient	NOUN
app-558	18	3	with	with	ADP
app-558	18	4	mild	mild	ADJ
app-558	18	5	i.d	i.d	PROPN
app-558	18	6	.	.	PROPN
app-558	18	7	showed	show	VERB
app-558	18	8	a	a	DET
app-558	18	9	two	two	NUM
app-558	18	10	-	-	ADJ
app-558	18	11	fold	fold	ADJ
app-558	18	12	increase	increase	NOUN
app-558	18	13	in	in	ADP
app-558	18	14	sialic	sialic	ADJ
app-558	18	15	acid	acid	NOUN
app-558	18	16	levels	level	NOUN
app-558	18	17	when	when	SCONJ
app-558	18	18	compared	compare	VERB
app-558	18	19	to	to	ADP
app-558	18	20	controls	control	NOUN
app-558	18	21	.	.	PUNCT
app-558	19	1	a	a	DET
app-558	19	2	significant	significant	ADJ
app-558	19	3	correlation	correlation	NOUN
app-558	19	4	was	be	AUX
app-558	19	5	found	find	VERB
app-558	19	6	between	between	ADP
app-558	19	7	an	an	DET
app-558	19	8	increased	increase	VERB
app-558	19	9	gne	gne	PROPN
app-558	19	10	mrna	mrna	NOUN
app-558	19	11	and	and	CCONJ
app-558	19	12	low	low	ADJ
app-558	19	13	urinary	urinary	ADJ
app-558	19	14	sialic	sialic	ADJ
app-558	19	15	acid	acid	NOUN
app-558	19	16	levels	level	NOUN
app-558	19	17	from	from	ADP
app-558	19	18	severe	severe	ADJ
app-558	19	19	i.d	i.d	PROPN
app-558	19	20	.	.	PROPN
app-558	19	21	patients	patient	NOUN
app-558	19	22	.	.	PUNCT
app-558	20	1	conclusion	conclusion	NOUN
app-558	20	2	:	:	PUNCT
app-558	20	3	the	the	DET
app-558	20	4	effect	effect	NOUN
app-558	20	5	of	of	ADP
app-558	20	6	the	the	DET
app-558	20	7	gne	gne	PROPN
app-558	20	8	gene	gene	NOUN
app-558	20	9	is	be	AUX
app-558	20	10	beyond	beyond	ADP
app-558	20	11	hyposialylation	hyposialylation	NOUN
app-558	20	12	that	that	PRON
app-558	20	13	could	could	AUX
app-558	20	14	hinder	hinder	VERB
app-558	20	15	n	n	CCONJ
app-558	20	16	-	-	PUNCT
app-558	20	17	glycan	glycan	NOUN
app-558	20	18	structure	structure	NOUN
app-558	20	19	and	and	CCONJ
app-558	20	20	sialic	sialic	ADJ
app-558	20	21	acid	acid	NOUN
app-558	20	22	biosynthesis	biosynthesis	NOUN
app-558	20	23	.	.	PUNCT
app-558	21	1	the	the	DET
app-558	21	2	study	study	NOUN
app-558	21	3	highlighted	highlight	VERB
app-558	21	4	the	the	DET
app-558	21	5	possible	possible	ADJ
app-558	21	6	involvement	involvement	NOUN
app-558	21	7	of	of	ADP
app-558	21	8	sialic	sialic	ADJ
app-558	21	9	acid	acid	NOUN
app-558	21	10	levels	level	NOUN
app-558	21	11	with	with	ADP
app-558	21	12	different	different	ADJ
app-558	21	13	degrees	degree	NOUN
app-558	21	14	of	of	ADP
app-558	21	15	intellectual	intellectual	ADJ
app-558	21	16	disabilities	disability	NOUN
app-558	21	17	in	in	ADP
app-558	21	18	pakistani	pakistani	ADJ
app-558	21	19	children	child	NOUN
app-558	21	20	and	and	CCONJ
app-558	21	21	adolescents	adolescent	NOUN
app-558	21	22	.	.	PUNCT
app-558	22	1	keywords	keyword	NOUN
app-558	22	2	sialuria	sialuria	PROPN
app-558	22	3	,	,	PUNCT
app-558	22	4	intellectual	intellectual	ADJ
app-558	22	5	disability	disability	NOUN
app-558	22	6	,	,	PUNCT
app-558	22	7	metabolic	metabolic	NOUN
app-558	22	8	error	error	NOUN
app-558	22	9	.	.	PUNCT
app-558	23	1	citation	citation	NOUN
app-558	23	2	:	:	PUNCT
app-558	23	3	ishtiaq	ishtiaq	PROPN
app-558	23	4	h	h	PROPN
app-558	23	5	,	,	PUNCT
app-558	23	6	siddiqui	siddiqui	NOUN
app-558	23	7	s	s	PART
app-558	23	8	,	,	PUNCT
app-558	23	9	nawaz	nawaz	ADJ
app-558	23	10	r	r	NOUN
app-558	23	11	,	,	PUNCT
app-558	23	12	hussain	hussain	PROPN
app-558	23	13	ma	ma	PROPN
app-558	23	14	,	,	PUNCT
app-558	23	15	imtiaz	imtiaz	PROPN
app-558	23	16	f	f	PROPN
app-558	23	17	,	,	PUNCT
app-558	23	18	haque	haque	PROPN
app-558	23	19	z.	z.	PROPN
app-558	24	1	the	the	DET
app-558	24	2	identification	identification	NOUN
app-558	24	3	of	of	ADP
app-558	24	4	sialuria	sialuria	PROPN
app-558	24	5	with	with	ADP
app-558	24	6	different	different	ADJ
app-558	24	7	degrees	degree	NOUN
app-558	24	8	of	of	ADP
app-558	24	9	intellectual	intellectual	ADJ
app-558	24	10	disabilities	disability	NOUN
app-558	24	11	in	in	ADP
app-558	24	12	children	child	NOUN
app-558	24	13	and	and	CCONJ
app-558	24	14	adolescents	adolescent	NOUN
app-558	24	15	.	.	PUNCT
app-558	25	1	app	app	PROPN
app-558	25	2	.	.	PUNCT
app-558	26	1	2021;8(2):86	2021;8(2):86	NUM
app-558	26	2	-	-	SYM
app-558	26	3	95	95	NUM
app-558	26	4	corresponding	corresponding	ADJ
app-558	26	5	author	author	NOUN
app-558	26	6	email	email	NOUN
app-558	26	7	:	:	PUNCT
app-558	26	8	siddisbs@yahoo.com	siddisbs@yahoo.com	X
app-558	27	1	doi	doi	NOUN
app-558	27	2	:	:	PUNCT
app-558	27	3	10.29052/2412	10.29052/2412	NUM
app-558	27	4	-	-	SYM
app-558	27	5	3188.v8.i2.2021.86	3188.v8.i2.2021.86	NUM
app-558	27	6	-	-	SYM
app-558	27	7	95	95	NUM
app-558	27	8	received	receive	VERB
app-558	27	9	06/09/2021	06/09/2021	NOUN
app-558	27	10	accepted	accept	VERB
app-558	27	11	01/10/2021	01/10/2021	NUM
app-558	28	1	published	publish	VERB
app-558	28	2	01/12/2021	01/12/2021	NUM
app-558	28	3	copyright	copyright	NOUN
app-558	28	4	©	©	ADP
app-558	28	5	the	the	DET
app-558	28	6	author(s	author(s	NOUN
app-558	28	7	)	)	PUNCT
app-558	28	8	.	.	PUNCT
app-558	29	1	2021	2021	NUM
app-558	29	2	this	this	PRON
app-558	29	3	is	be	AUX
app-558	29	4	an	an	DET
app-558	29	5	open	open	ADJ
app-558	29	6	access	access	NOUN
app-558	29	7	article	article	NOUN
app-558	29	8	distributed	distribute	VERB
app-558	29	9	under	under	ADP
app-558	29	10	the	the	DET
app-558	29	11	terms	term	NOUN
app-558	29	12	of	of	ADP
app-558	29	13	the	the	DET
app-558	29	14	creative	creative	ADJ
app-558	29	15	commons	common	NOUN
app-558	29	16	attribution	attribution	NOUN
app-558	29	17	4.0	4.0	NUM
app-558	29	18	international	international	ADJ
app-558	29	19	license	license	NOUN
app-558	29	20	,	,	PUNCT
app-558	29	21	which	which	PRON
app-558	29	22	permits	permit	VERB
app-558	29	23	unrestricted	unrestricted	ADJ
app-558	29	24	use	use	NOUN
app-558	29	25	,	,	PUNCT
app-558	29	26	distribution	distribution	NOUN
app-558	29	27	,	,	PUNCT
app-558	29	28	and	and	CCONJ
app-558	29	29	reproduction	reproduction	NOUN
app-558	29	30	in	in	ADP
app-558	29	31	any	any	DET
app-558	29	32	medium	medium	NOUN
app-558	29	33	,	,	PUNCT
app-558	29	34	provided	provide	VERB
app-558	29	35	the	the	DET
app-558	29	36	original	original	ADJ
app-558	29	37	author	author	NOUN
app-558	29	38	and	and	CCONJ
app-558	29	39	source	source	NOUN
app-558	29	40	are	be	AUX
app-558	29	41	credited	credit	VERB
app-558	29	42	.	.	PUNCT
app-558	30	1	funding	funding	NOUN
app-558	30	2	:	:	PUNCT
app-558	30	3	the	the	DET
app-558	30	4	authors	author	NOUN
app-558	30	5	would	would	AUX
app-558	30	6	like	like	VERB
app-558	30	7	to	to	PART
app-558	30	8	thank	thank	VERB
app-558	30	9	hec	hec	PROPN
app-558	30	10	(	(	PUNCT
app-558	30	11	grant	grant	VERB
app-558	30	12	no	no	DET
app-558	30	13	#	#	NOUN
app-558	30	14	1028	1028	NUM
app-558	30	15	)	)	PUNCT
app-558	30	16	and	and	CCONJ
app-558	30	17	recurring	recur	VERB
app-558	30	18	grant	grant	NOUN
app-558	30	19	,	,	PUNCT
app-558	30	20	pcmd	pcmd	PROPN
app-558	30	21	,	,	PUNCT
app-558	30	22	for	for	ADP
app-558	30	23	providing	provide	VERB
app-558	30	24	financial	financial	ADJ
app-558	30	25	support	support	NOUN
app-558	30	26	.	.	PUNCT
app-558	31	1	conflicts	conflict	NOUN
app-558	31	2	of	of	ADP
app-558	31	3	interests	interest	NOUN
app-558	31	4	:	:	PUNCT
app-558	31	5	the	the	DET
app-558	31	6	authors	author	NOUN
app-558	31	7	have	have	AUX
app-558	31	8	declared	declare	VERB
app-558	31	9	that	that	SCONJ
app-558	31	10	no	no	DET
app-558	31	11	competing	compete	VERB
app-558	31	12	interests	interest	NOUN
app-558	31	13	exist	exist	VERB
app-558	31	14	.	.	PUNCT
app-558	32	1	https://doi.org/10.29052/2412-3188.v8.i2.2021	https://doi.org/10.29052/2412-3188.v8.i2.2021	PROPN
app-558	32	2	.	.	PUNCT
app-558	33	1	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
app-558	33	2	)	)	PUNCT
app-558	33	3	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
app-558	33	4	)	)	PUNCT
app-558	33	5	87	87	NUM
app-558	33	6	issn	issn	PROPN
app-558	33	7	2412	2412	NUM
app-558	33	8	-	-	SYM
app-558	33	9	3188	3188	NUM
app-558	33	10	(	(	PUNCT
app-558	33	11	online	online	NOUN
app-558	33	12	)	)	PUNCT
app-558	33	13	|	|	ADV
app-558	33	14	2410	2410	NUM
app-558	33	15	-	-	SYM
app-558	33	16	1354	1354	NUM
app-558	33	17	(	(	PUNCT
app-558	33	18	print	print	NOUN
app-558	33	19	)	)	PUNCT
app-558	33	20	app|	app|	NOUN
app-558	33	21	published	publish	VERB
app-558	33	22	by	by	ADP
app-558	33	23	aeirc|	aeirc|	ADP
app-558	33	24	volume	volume	NOUN
app-558	33	25	8	8	NUM
app-558	33	26	issue	issue	NOUN
app-558	33	27	2	2	NUM
app-558	33	28	introduction	introduction	NOUN
app-558	33	29	sialuria	sialuria	PROPN
app-558	33	30	,	,	PUNCT
app-558	33	31	an	an	DET
app-558	33	32	autosomal	autosomal	ADJ
app-558	33	33	dominant	dominant	ADJ
app-558	33	34	disorder	disorder	NOUN
app-558	33	35	found	find	VERB
app-558	33	36	in	in	ADP
app-558	33	37	patients	patient	NOUN
app-558	33	38	with	with	ADP
app-558	33	39	a	a	DET
app-558	33	40	defective	defective	ADJ
app-558	33	41	synthesis	synthesis	NOUN
app-558	33	42	of	of	ADP
app-558	33	43	a	a	DET
app-558	33	44	key	key	ADJ
app-558	33	45	enzyme	enzyme	NOUN
app-558	33	46	udp	udp	NOUN
app-558	33	47	-	-	PUNCT
app-558	33	48	n	n	CCONJ
app-558	33	49	-	-	PUNCT
app-558	33	50	acetylglucosamine2	acetylglucosamine2	NOUN
app-558	33	51	-	-	PUNCT
app-558	33	52	epimerase	epimerase	NOUN
app-558	33	53	n	n	CCONJ
app-558	33	54	-	-	PUNCT
app-558	33	55	acetylmannosamine	acetylmannosamine	NOUN
app-558	33	56	kinase	kinase	PROPN
app-558	33	57	(	(	PUNCT
app-558	33	58	gne	gne	PROPN
app-558	33	59	)	)	PUNCT
app-558	33	60	due	due	ADP
app-558	33	61	to	to	ADP
app-558	33	62	the	the	DET
app-558	33	63	mutation	mutation	NOUN
app-558	33	64	in	in	ADP
app-558	33	65	the	the	DET
app-558	33	66	r263l	r263l	PROPN
app-558	33	67	region	region	NOUN
app-558	33	68	of	of	ADP
app-558	33	69	the	the	DET
app-558	33	70	gne	gne	PROPN
app-558	33	71	gene	gene	NOUN
app-558	33	72	.	.	PUNCT
app-558	34	1	due	due	ADP
app-558	34	2	to	to	ADP
app-558	34	3	this	this	DET
app-558	34	4	mutation	mutation	NOUN
app-558	34	5	,	,	PUNCT
app-558	34	6	the	the	DET
app-558	34	7	negative	negative	ADJ
app-558	34	8	feedback	feedback	NOUN
app-558	34	9	inhibition	inhibition	NOUN
app-558	34	10	is	be	AUX
app-558	34	11	lost	lose	VERB
app-558	34	12	,	,	PUNCT
app-558	34	13	disrupting	disrupt	VERB
app-558	34	14	sialic	sialic	ADJ
app-558	34	15	acid	acid	NOUN
app-558	34	16	synthesis	synthesis	NOUN
app-558	34	17	in	in	ADP
app-558	34	18	mammals1	mammals1	PROPN
app-558	34	19	.	.	PUNCT
app-558	35	1	in	in	ADP
app-558	35	2	sialuria	sialuria	PROPN
app-558	35	3	,	,	PUNCT
app-558	35	4	an	an	DET
app-558	35	5	increased	increase	VERB
app-558	35	6	overproduction	overproduction	NOUN
app-558	35	7	of	of	ADP
app-558	35	8	free	free	ADJ
app-558	35	9	sialic	sialic	ADJ
app-558	35	10	acid	acid	NOUN
app-558	35	11	is	be	AUX
app-558	35	12	found	find	VERB
app-558	35	13	in	in	ADP
app-558	35	14	the	the	DET
app-558	35	15	cytosol	cytosol	NOUN
app-558	35	16	.	.	PUNCT
app-558	36	1	therefore	therefore	ADV
app-558	36	2	,	,	PUNCT
app-558	36	3	patients	patient	NOUN
app-558	36	4	who	who	PRON
app-558	36	5	exhibit	exhibit	VERB
app-558	36	6	an	an	DET
app-558	36	7	increased	increased	ADJ
app-558	36	8	excretion	excretion	NOUN
app-558	36	9	of	of	ADP
app-558	36	10	sialic	sialic	ADJ
app-558	36	11	acid	acid	NOUN
app-558	36	12	in	in	ADP
app-558	36	13	urine	urine	NOUN
app-558	36	14	show	show	VERB
app-558	36	15	many	many	ADJ
app-558	36	16	difficulties	difficulty	NOUN
app-558	36	17	with	with	ADP
app-558	36	18	developmental	developmental	ADJ
app-558	36	19	delays	delay	NOUN
app-558	36	20	.	.	PUNCT
app-558	37	1	previously	previously	ADV
app-558	37	2	a	a	DET
app-558	37	3	transgenic	transgenic	NOUN
app-558	37	4	mouse	mouse	NOUN
app-558	37	5	line	line	NOUN
app-558	37	6	that	that	PRON
app-558	37	7	expresses	express	VERB
app-558	38	1	gne	gne	PROPN
app-558	38	2	having	have	VERB
app-558	38	3	a	a	DET
app-558	38	4	mutation	mutation	NOUN
app-558	38	5	in	in	ADP
app-558	38	6	the	the	DET
app-558	38	7	same	same	ADJ
app-558	38	8	region	region	NOUN
app-558	38	9	r263l	r263l	PROPN
app-558	39	1	has	have	AUX
app-558	39	2	been	be	AUX
app-558	39	3	shown	show	VERB
app-558	39	4	to	to	PART
app-558	39	5	produce	produce	VERB
app-558	39	6	and	and	CCONJ
app-558	39	7	excrete	excrete	ADJ
app-558	39	8	400	400	NUM
app-558	39	9	times	time	NOUN
app-558	39	10	higher	high	ADJ
app-558	39	11	rna	rna	NOUN
app-558	39	12	expression	expression	NOUN
app-558	39	13	of	of	ADP
app-558	39	14	mutated	mutate	VERB
app-558	39	15	gne	gne	PROPN
app-558	39	16	gene	gene	NOUN
app-558	39	17	than	than	ADP
app-558	39	18	the	the	DET
app-558	39	19	wild	wild	ADJ
app-558	39	20	type	type	NOUN
app-558	39	21	mice	mouse	NOUN
app-558	39	22	.	.	PUNCT
app-558	40	1	n	n	CCONJ
app-558	40	2	-	-	PUNCT
app-558	40	3	acetylneuraminic	acetylneuraminic	ADJ
app-558	40	4	acid	acid	NOUN
app-558	40	5	levels	level	NOUN
app-558	40	6	were	be	AUX
app-558	40	7	also	also	ADV
app-558	40	8	higher	high	ADJ
app-558	40	9	in	in	ADP
app-558	40	10	the	the	DET
app-558	40	11	brain	brain	NOUN
app-558	40	12	cytoplasm	cytoplasm	NOUN
app-558	40	13	with	with	ADP
app-558	40	14	an	an	DET
app-558	40	15	increased	increase	VERB
app-558	40	16	polysialylation	polysialylation	NOUN
app-558	40	17	of	of	ADP
app-558	40	18	neural	neural	ADJ
app-558	40	19	cell	cell	NOUN
app-558	40	20	adhesion	adhesion	NOUN
app-558	40	21	molecule	molecule	NOUN
app-558	40	22	(	(	PUNCT
app-558	40	23	ncam	ncam	NOUN
app-558	40	24	)	)	PUNCT
app-558	40	25	in	in	ADP
app-558	40	26	transgenic	transgenic	NOUN
app-558	40	27	mice	mouse	NOUN
app-558	40	28	than	than	ADP
app-558	40	29	in	in	ADP
app-558	40	30	wild	wild	ADJ
app-558	40	31	type	type	NOUN
app-558	40	32	.	.	PUNCT
app-558	41	1	however	however	ADV
app-558	41	2	,	,	PUNCT
app-558	41	3	the	the	DET
app-558	41	4	same	same	ADJ
app-558	41	5	study	study	NOUN
app-558	41	6	showed	show	VERB
app-558	41	7	minor	minor	ADJ
app-558	41	8	differences	difference	NOUN
app-558	41	9	in	in	ADP
app-558	41	10	membrane	membrane	NOUN
app-558	41	11	-	-	PUNCT
app-558	41	12	bound	bind	VERB
app-558	41	13	sialylation	sialylation	NOUN
app-558	41	14	in	in	ADP
app-558	41	15	many	many	ADJ
app-558	41	16	organs	organ	NOUN
app-558	41	17	.	.	PUNCT
app-558	42	1	in	in	ADP
app-558	42	2	contrast	contrast	NOUN
app-558	42	3	to	to	ADP
app-558	42	4	this	this	PRON
app-558	42	5	,	,	PUNCT
app-558	42	6	a	a	DET
app-558	42	7	significantly	significantly	ADV
app-558	42	8	higher	high	ADJ
app-558	42	9	expression	expression	NOUN
app-558	42	10	of	of	ADP
app-558	42	11	sialylation	sialylation	NOUN
app-558	42	12	was	be	AUX
app-558	42	13	observed	observe	VERB
app-558	42	14	on	on	ADP
app-558	42	15	the	the	DET
app-558	42	16	surface	surface	NOUN
app-558	42	17	of	of	ADP
app-558	42	18	leukocytes	leukocyte	NOUN
app-558	42	19	.	.	PUNCT
app-558	43	1	kreuzmann	kreuzmann	NOUN
app-558	43	2	and	and	CCONJ
app-558	43	3	colleagues	colleague	NOUN
app-558	43	4	(	(	PUNCT
app-558	43	5	2017	2017	NUM
app-558	43	6	)	)	PUNCT
app-558	43	7	proved	prove	VERB
app-558	43	8	that	that	SCONJ
app-558	43	9	the	the	DET
app-558	43	10	developmental	developmental	ADJ
app-558	43	11	delays	delay	NOUN
app-558	43	12	associated	associate	VERB
app-558	43	13	with	with	ADP
app-558	43	14	sialuria	sialuria	PROPN
app-558	43	15	patient	patient	NOUN
app-558	43	16	are	be	AUX
app-558	43	17	due	due	ADJ
app-558	43	18	to	to	ADP
app-558	43	19	increased	increase	VERB
app-558	43	20	intracellular	intracellular	ADJ
app-558	43	21	levels	level	NOUN
app-558	43	22	of	of	ADP
app-558	43	23	sialic	sialic	ADJ
app-558	43	24	acid	acid	NOUN
app-558	43	25	that	that	PRON
app-558	43	26	causes	cause	VERB
app-558	43	27	polysialylation	polysialylation	NOUN
app-558	43	28	on	on	ADP
app-558	43	29	ncam1	ncam1	PROPN
app-558	43	30	.	.	PUNCT
app-558	44	1	sialic	sialic	ADJ
app-558	44	2	acids	acid	NOUN
app-558	44	3	are	be	AUX
app-558	44	4	composed	compose	VERB
app-558	44	5	of	of	ADP
app-558	44	6	glycoproteins	glycoprotein	NOUN
app-558	44	7	and	and	CCONJ
app-558	44	8	glycolipids	glycolipid	NOUN
app-558	44	9	responsible	responsible	ADJ
app-558	44	10	for	for	ADP
app-558	44	11	important	important	ADJ
app-558	44	12	cellular	cellular	ADJ
app-558	44	13	functions	function	NOUN
app-558	44	14	,	,	PUNCT
app-558	44	15	infection	infection	NOUN
app-558	44	16	,	,	PUNCT
app-558	44	17	and	and	CCONJ
app-558	44	18	metastasis	metastasis	NOUN
app-558	44	19	.	.	PUNCT
app-558	45	1	its	its	PRON
app-558	45	2	catabolism	catabolism	NOUN
app-558	45	3	is	be	AUX
app-558	45	4	important	important	ADJ
app-558	45	5	for	for	ADP
app-558	45	6	a	a	DET
app-558	45	7	healthy	healthy	ADJ
app-558	45	8	heart	heart	NOUN
app-558	45	9	and	and	CCONJ
app-558	45	10	skeletal	skeletal	ADJ
app-558	45	11	muscle	muscle	NOUN
app-558	45	12	functions	function	NOUN
app-558	45	13	not	not	PART
app-558	45	14	only	only	ADV
app-558	45	15	in	in	ADP
app-558	45	16	humans	human	NOUN
app-558	45	17	but	but	CCONJ
app-558	45	18	in	in	ADP
app-558	45	19	zebrafish	zebrafish	NUM
app-558	45	20	as	as	ADP
app-558	45	21	well2	well2	NOUN
app-558	45	22	.	.	PUNCT
app-558	46	1	siblings	sibling	NOUN
app-558	46	2	with	with	ADP
app-558	46	3	sialuria	sialuria	PROPN
app-558	46	4	,	,	PUNCT
app-558	46	5	exercise	exercise	NOUN
app-558	46	6	intolerance	intolerance	NOUN
app-558	46	7	/	/	SYM
app-558	46	8	muscle	muscle	NOUN
app-558	46	9	wasting	wasting	NOUN
app-558	46	10	,	,	PUNCT
app-558	46	11	and	and	CCONJ
app-558	46	12	cardiac	cardiac	ADJ
app-558	46	13	symptoms	symptom	NOUN
app-558	46	14	were	be	AUX
app-558	46	15	reported	report	VERB
app-558	46	16	previously	previously	ADV
app-558	46	17	having	have	VERB
app-558	46	18	heterozygous	heterozygous	ADJ
app-558	46	19	mutations	mutation	NOUN
app-558	46	20	in	in	ADP
app-558	46	21	n	n	CCONJ
app-558	46	22	-	-	PUNCT
app-558	46	23	acetylneuraminate	acetylneuraminate	ADJ
app-558	46	24	pyruvate	pyruvate	NOUN
app-558	46	25	lyase	lyase	NOUN
app-558	46	26	gene	gene	NOUN
app-558	46	27	(	(	PUNCT
app-558	46	28	npl	npl	NOUN
app-558	46	29	)	)	PUNCT
app-558	46	30	at	at	ADP
app-558	46	31	[	[	X
app-558	46	32	chr1:182775324c	chr1:182775324c	X
app-558	46	33	>	>	X
app-558	46	34	t	t	PROPN
app-558	46	35	(	(	PUNCT
app-558	46	36	c.187c	c.187c	PROPN
app-558	46	37	>	>	PROPN
app-558	46	38	t	t	PROPN
app-558	46	39	;	;	PUNCT
app-558	46	40	p.arg63cys	p.arg63cy	NOUN
app-558	46	41	)	)	PUNCT
app-558	46	42	and	and	CCONJ
app-558	46	43	chr1:182772897a	chr1:182772897a	VERB
app-558	46	44	>	>	X
app-558	46	45	g	g	PROPN
app-558	46	46	(	(	PUNCT
app-558	46	47	c.133a	c.133a	NOUN
app-558	46	48	>	>	X
app-558	46	49	g	g	NOUN
app-558	46	50	;	;	PUNCT
app-558	46	51	p.asn45asp	p.asn45asp	NOUN
app-558	46	52	)	)	PUNCT
app-558	46	53	]	]	PUNCT
app-558	46	54	.	.	PUNCT
app-558	47	1	the	the	DET
app-558	47	2	effect	effect	NOUN
app-558	47	3	was	be	AUX
app-558	47	4	observed	observe	VERB
app-558	47	5	on	on	ADP
app-558	47	6	sialic	sialic	ADJ
app-558	47	7	acid	acid	NOUN
app-558	47	8	catabolism	catabolism	NOUN
app-558	47	9	and	and	CCONJ
app-558	47	10	cell	cell	NOUN
app-558	47	11	-	-	PUNCT
app-558	47	12	specific	specific	ADJ
app-558	47	13	reductions	reduction	NOUN
app-558	47	14	in	in	ADP
app-558	47	15	n	n	CCONJ
app-558	47	16	-	-	PUNCT
app-558	47	17	acetyl	acetyl	NOUN
app-558	47	18	mannosamine	mannosamine	NOUN
app-558	47	19	(	(	PUNCT
app-558	47	20	mannac	mannac	NOUN
app-558	47	21	)	)	PUNCT
app-558	47	22	levels	level	NOUN
app-558	47	23	.	.	PUNCT
app-558	48	1	knockdown	knockdown	NOUN
app-558	48	2	npl	npl	PROPN
app-558	48	3	in	in	ADP
app-558	48	4	zebrafish	zebrafish	ADJ
app-558	48	5	leads	lead	NOUN
app-558	48	6	to	to	ADP
app-558	48	7	severe	severe	ADJ
app-558	48	8	skeletal	skeletal	ADJ
app-558	48	9	myopathy	myopathy	ADJ
app-558	48	10	and	and	CCONJ
app-558	48	11	cardiac	cardiac	ADJ
app-558	48	12	edema	edema	NOUN
app-558	48	13	,	,	PUNCT
app-558	48	14	resembling	resemble	VERB
app-558	48	15	the	the	DET
app-558	48	16	human	human	ADJ
app-558	48	17	phenotype	phenotype	NOUN
app-558	48	18	.	.	PUNCT
app-558	49	1	however	however	ADV
app-558	49	2	,	,	PUNCT
app-558	49	3	the	the	DET
app-558	49	4	phenotype	phenotype	NOUN
app-558	49	5	was	be	AUX
app-558	49	6	rescued	rescue	VERB
app-558	49	7	by	by	ADP
app-558	49	8	expressing	express	VERB
app-558	49	9	wild	wild	ADJ
app-558	49	10	-	-	PUNCT
app-558	49	11	type	type	NOUN
app-558	49	12	human	human	PROPN
app-558	49	13	npl	npl	PROPN
app-558	49	14	.	.	PUNCT
app-558	50	1	however	however	ADV
app-558	50	2	,	,	PUNCT
app-558	50	3	there	there	PRON
app-558	50	4	was	be	VERB
app-558	50	5	no	no	DET
app-558	50	6	change	change	NOUN
app-558	50	7	when	when	SCONJ
app-558	50	8	p.arg63cys	p.arg63cy	NOUN
app-558	50	9	or	or	CCONJ
app-558	50	10	p.asn45asp	p.asn45asp	PROPN
app-558	50	11	mutants	mutant	NOUN
app-558	50	12	were	be	AUX
app-558	50	13	expressed	express	VERB
app-558	50	14	.	.	PUNCT
app-558	51	1	surprisingly	surprisingly	ADV
app-558	51	2	the	the	DET
app-558	51	3	phenotypes	phenotype	NOUN
app-558	51	4	in	in	ADP
app-558	51	5	zebrafish	zebrafish	NUM
app-558	51	6	were	be	AUX
app-558	51	7	rescued	rescue	VERB
app-558	51	8	by	by	ADP
app-558	51	9	feeding	feed	VERB
app-558	51	10	catabolic	catabolic	ADJ
app-558	51	11	products	product	NOUN
app-558	51	12	of	of	ADP
app-558	51	13	npl	npl	NOUN
app-558	51	14	:	:	PUNCT
app-558	51	15	n	n	CCONJ
app-558	51	16	-	-	PUNCT
app-558	51	17	acetyl	acetyl	NOUN
app-558	51	18	glucosamine	glucosamine	NOUN
app-558	51	19	(	(	PUNCT
app-558	51	20	glcnac	glcnac	NOUN
app-558	51	21	)	)	PUNCT
app-558	51	22	and	and	CCONJ
app-558	51	23	mannac2	mannac2	PROPN
app-558	51	24	,	,	PUNCT
app-558	51	25	suggesting	suggest	VERB
app-558	51	26	monosaccharide	monosaccharide	NOUN
app-558	51	27	replacement	replacement	NOUN
app-558	51	28	therapy	therapy	NOUN
app-558	51	29	for	for	ADP
app-558	51	30	humans	human	NOUN
app-558	51	31	.	.	PUNCT
app-558	52	1	as	as	SCONJ
app-558	52	2	sialuria	sialuria	PROPN
app-558	52	3	regulates	regulate	VERB
app-558	52	4	neural	neural	ADJ
app-558	52	5	development	development	NOUN
app-558	52	6	,	,	PUNCT
app-558	52	7	neural	neural	ADJ
app-558	52	8	regeneration	regeneration	NOUN
app-558	52	9	,	,	PUNCT
app-558	52	10	learning	learning	NOUN
app-558	52	11	,	,	PUNCT
app-558	52	12	and	and	CCONJ
app-558	52	13	memory3,4	memory3,4	PROPN
app-558	52	14	,	,	PUNCT
app-558	52	15	any	any	DET
app-558	52	16	alterations	alteration	NOUN
app-558	52	17	can	can	AUX
app-558	52	18	alter	alter	VERB
app-558	52	19	humans	human	NOUN
app-558	52	20	'	'	PART
app-558	52	21	intellectual	intellectual	ADJ
app-558	52	22	levels	level	NOUN
app-558	52	23	.	.	PUNCT
app-558	53	1	therefore	therefore	ADV
app-558	53	2	,	,	PUNCT
app-558	53	3	in	in	ADP
app-558	53	4	this	this	DET
app-558	53	5	study	study	NOUN
app-558	53	6	,	,	PUNCT
app-558	53	7	we	we	PRON
app-558	53	8	have	have	AUX
app-558	53	9	investigated	investigate	VERB
app-558	53	10	the	the	DET
app-558	53	11	mrna	mrna	PROPN
app-558	53	12	expression	expression	NOUN
app-558	53	13	levels	level	NOUN
app-558	53	14	of	of	ADP
app-558	53	15	the	the	DET
app-558	53	16	gne	gne	PROPN
app-558	53	17	gene	gene	NOUN
app-558	53	18	in	in	ADP
app-558	53	19	blood	blood	NOUN
app-558	53	20	and	and	CCONJ
app-558	53	21	sialic	sialic	ADJ
app-558	53	22	acid	acid	NOUN
app-558	53	23	levels	level	NOUN
app-558	53	24	in	in	ADP
app-558	53	25	urine	urine	NOUN
app-558	53	26	,	,	PUNCT
app-558	53	27	of	of	ADP
app-558	53	28	the	the	DET
app-558	53	29	patients	patient	NOUN
app-558	53	30	with	with	ADP
app-558	53	31	different	different	ADJ
app-558	53	32	intellectual	intellectual	ADJ
app-558	53	33	disabilities	disability	NOUN
app-558	53	34	.	.	PUNCT
app-558	54	1	methodology	methodology	PROPN
app-558	54	2	subject	subject	NOUN
app-558	54	3	recruitment	recruitment	NOUN
app-558	54	4	and	and	CCONJ
app-558	54	5	ethical	ethical	ADJ
app-558	54	6	approval	approval	NOUN
app-558	54	7	this	this	DET
app-558	54	8	study	study	NOUN
app-558	54	9	was	be	AUX
app-558	54	10	approved	approve	VERB
app-558	54	11	by	by	ADP
app-558	54	12	the	the	DET
app-558	54	13	human	human	PROPN
app-558	54	14	ethics	ethics	PROPN
app-558	54	15	committee	committee	PROPN
app-558	54	16	of	of	ADP
app-558	54	17	the	the	DET
app-558	54	18	national	national	PROPN
app-558	54	19	institute	institute	PROPN
app-558	54	20	of	of	ADP
app-558	54	21	child	child	PROPN
app-558	54	22	health	health	PROPN
app-558	54	23	and	and	CCONJ
app-558	54	24	rehabilitation	rehabilitation	NOUN
app-558	54	25	center	center	NOUN
app-558	54	26	(	(	PUNCT
app-558	54	27	nich	nich	NOUN
app-558	54	28	)	)	PUNCT
app-558	54	29	,	,	PUNCT
app-558	54	30	jinnah	jinnah	PROPN
app-558	54	31	postgraduate	postgraduate	VERB
app-558	54	32	medical	medical	ADJ
app-558	54	33	center	center	NOUN
app-558	54	34	(	(	PUNCT
app-558	54	35	jpmc	jpmc	PROPN
app-558	54	36	)	)	PUNCT
app-558	54	37	,	,	PUNCT
app-558	54	38	with	with	ADP
app-558	54	39	the	the	DET
app-558	54	40	ethic	ethic	ADJ
app-558	54	41	number	number	NOUN
app-558	54	42	of	of	ADP
app-558	54	43	hea	hea	PROPN
app-558	54	44	no	no	PROPN
app-558	54	45	.	.	PUNCT
app-558	55	1	f.2	f.2	NOUN
app-558	55	2	-	-	PUNCT
app-558	55	3	81/2008	81/2008	NOUN
app-558	55	4	-	-	PUNCT
app-558	55	5	genl/4086	genl/4086	NOUN
app-558	55	6	/	/	SYM
app-558	55	7	jpmc	jpmc	PROPN
app-558	55	8	.	.	PUNCT
app-558	56	1	parents	parent	NOUN
app-558	56	2	of	of	ADP
app-558	56	3	every	every	DET
app-558	56	4	subject	subject	NOUN
app-558	56	5	were	be	AUX
app-558	56	6	requested	request	VERB
app-558	56	7	to	to	PART
app-558	56	8	read	read	VERB
app-558	56	9	and	and	CCONJ
app-558	56	10	understand	understand	VERB
app-558	56	11	the	the	DET
app-558	56	12	consent	consent	NOUN
app-558	56	13	form	form	NOUN
app-558	56	14	before	before	ADP
app-558	56	15	signing	sign	VERB
app-558	56	16	.	.	PUNCT
app-558	57	1	the	the	DET
app-558	57	2	data	datum	NOUN
app-558	57	3	was	be	AUX
app-558	57	4	collected	collect	VERB
app-558	57	5	from	from	ADP
app-558	57	6	15th	15th	ADJ
app-558	57	7	jan	jan	PROPN
app-558	57	8	to	to	ADP
app-558	57	9	30th	30th	NUM
app-558	57	10	july	july	PROPN
app-558	57	11	2018	2018	NUM
app-558	57	12	.	.	PUNCT
app-558	58	1	overall	overall	ADJ
app-558	58	2	102	102	NUM
app-558	58	3	subjects	subject	NOUN
app-558	58	4	were	be	AUX
app-558	58	5	used	use	VERB
app-558	58	6	for	for	ADP
app-558	58	7	mrna	mrna	NOUN
app-558	58	8	expression	expression	NOUN
app-558	58	9	i.e.	i.e.	X
app-558	58	10	controls	control	NOUN
app-558	58	11	(	(	PUNCT
app-558	58	12	n=51	n=51	NOUN
app-558	58	13	)	)	PUNCT
app-558	58	14	and	and	CCONJ
app-558	58	15	patients	patient	NOUN
app-558	58	16	(	(	PUNCT
app-558	58	17	n=51	n=51	NOUN
app-558	58	18	)	)	PUNCT
app-558	58	19	.	.	PUNCT
app-558	59	1	all	all	DET
app-558	59	2	subjects	subject	NOUN
app-558	59	3	were	be	AUX
app-558	59	4	between	between	ADP
app-558	59	5	the	the	DET
app-558	59	6	ages	age	NOUN
app-558	59	7	of	of	ADP
app-558	59	8	0	0	NUM
app-558	59	9	-	-	SYM
app-558	59	10	17	17	NUM
app-558	59	11	years	year	NOUN
app-558	59	12	(	(	PUNCT
app-558	59	13	male	male	NOUN
app-558	59	14	/	/	SYM
app-558	59	15	females	female	NOUN
app-558	59	16	)	)	PUNCT
app-558	59	17	.	.	PUNCT
app-558	60	1	these	these	DET
app-558	60	2	subjects	subject	NOUN
app-558	60	3	were	be	AUX
app-558	60	4	diagnosed	diagnose	VERB
app-558	60	5	according	accord	VERB
app-558	60	6	to	to	ADP
app-558	60	7	the	the	DET
app-558	60	8	diagnostic	diagnostic	ADJ
app-558	60	9	and	and	CCONJ
app-558	60	10	statistical	statistical	ADJ
app-558	60	11	manual	manual	NOUN
app-558	60	12	of	of	ADP
app-558	60	13	mental	mental	ADJ
app-558	60	14	disorders	disorder	NOUN
app-558	60	15	(	(	PUNCT
app-558	60	16	dms	dms	NOUN
app-558	60	17	-	-	PUNCT
app-558	60	18	iv	iv	NOUN
app-558	60	19	)	)	PUNCT
app-558	60	20	and	and	CCONJ
app-558	60	21	88	88	NUM
app-558	60	22	issn	issn	PROPN
app-558	60	23	2412	2412	NUM
app-558	60	24	-	-	SYM
app-558	60	25	3188	3188	NUM
app-558	60	26	(	(	PUNCT
app-558	60	27	online	online	NOUN
app-558	60	28	)	)	PUNCT
app-558	60	29	|	|	ADV
app-558	60	30	2410	2410	NUM
app-558	60	31	-	-	SYM
app-558	60	32	1354	1354	NUM
app-558	60	33	(	(	PUNCT
app-558	60	34	print	print	NOUN
app-558	60	35	)	)	PUNCT
app-558	60	36	app|	app|	NOUN
app-558	60	37	published	publish	VERB
app-558	60	38	by	by	ADP
app-558	60	39	aeirc|	aeirc|	ADP
app-558	60	40	volume	volume	NOUN
app-558	60	41	8	8	NUM
app-558	60	42	issue	issue	NOUN
app-558	60	43	2	2	NUM
app-558	60	44	international	international	ADJ
app-558	60	45	classification	classification	NOUN
app-558	60	46	of	of	ADP
app-558	60	47	diseases	disease	NOUN
app-558	60	48	(	(	PUNCT
app-558	60	49	icd10	icd10	PROPN
app-558	60	50	)	)	PUNCT
app-558	60	51	criteria	criterion	NOUN
app-558	60	52	and	and	CCONJ
app-558	60	53	presented	present	VERB
app-558	60	54	in	in	ADP
app-558	60	55	out	out	ADV
app-558	60	56	-	-	PUNCT
app-558	60	57	patientdepartment	patientdepartment	NOUN
app-558	60	58	(	(	PUNCT
app-558	60	59	opd	opd	PROPN
app-558	60	60	)	)	PUNCT
app-558	60	61	and	and	CCONJ
app-558	60	62	darul	darul	NOUN
app-558	60	63	-	-	PUNCT
app-558	60	64	sukun	sukun	PROPN
app-558	60	65	,	,	PUNCT
app-558	60	66	karachi	karachi	PROPN
app-558	60	67	,	,	PUNCT
app-558	60	68	pakistan	pakistan	PROPN
app-558	60	69	.	.	PUNCT
app-558	61	1	expert	expert	NOUN
app-558	61	2	psychiatrists	psychiatrist	NOUN
app-558	61	3	evaluated	evaluate	VERB
app-558	61	4	all	all	DET
app-558	61	5	subjects	subject	NOUN
app-558	61	6	through	through	ADP
app-558	61	7	history	history	NOUN
app-558	61	8	and	and	CCONJ
app-558	61	9	clinical	clinical	ADJ
app-558	61	10	examinations	examination	NOUN
app-558	61	11	.	.	PUNCT
app-558	62	1	biochemical	biochemical	ADJ
app-558	62	2	analysis	analysis	NOUN
app-558	62	3	of	of	ADP
app-558	62	4	urinary	urinary	ADJ
app-558	62	5	sialic	sialic	NOUN
app-558	62	6	acid	acid	NOUN
app-558	62	7	the	the	DET
app-558	62	8	levels	level	NOUN
app-558	62	9	of	of	ADP
app-558	62	10	free	free	ADJ
app-558	62	11	sialic	sialic	ADJ
app-558	62	12	acid	acid	NOUN
app-558	62	13	,	,	PUNCT
app-558	62	14	nacetylneuraminic	nacetylneuraminic	ADJ
app-558	62	15	acid	acid	NOUN
app-558	62	16	,	,	PUNCT
app-558	62	17	and	and	CCONJ
app-558	62	18	urine	urine	NOUN
app-558	62	19	were	be	AUX
app-558	62	20	measured	measure	VERB
app-558	62	21	using	use	VERB
app-558	62	22	the	the	DET
app-558	62	23	fluorometric	fluorometric	ADJ
app-558	62	24	sialic	sialic	ADJ
app-558	62	25	acid	acid	NOUN
app-558	62	26	kit	kit	NOUN
app-558	62	27	method	method	NOUN
app-558	62	28	(	(	PUNCT
app-558	62	29	biovision	biovision	NOUN
app-558	62	30	's	's	PART
app-558	62	31	cat	cat	NOUN
app-558	62	32	#	#	NOUN
app-558	62	33	k566	k566	PROPN
app-558	62	34	-	-	PUNCT
app-558	62	35	100	100	NUM
app-558	62	36	)	)	PUNCT
app-558	62	37	.	.	PUNCT
app-558	63	1	fluorescence	fluorescence	NOUN
app-558	63	2	at	at	ADP
app-558	63	3	ex	ex	PROPN
app-558	63	4	/	/	SYM
app-558	63	5	em	em	NOUN
app-558	63	6	535/587	535/587	PROPN
app-558	63	7	nm	nm	NOUN
app-558	63	8	was	be	AUX
app-558	63	9	measured	measure	VERB
app-558	63	10	using	use	VERB
app-558	63	11	the	the	DET
app-558	63	12	molecular	molecular	ADJ
app-558	63	13	device	device	NOUN
app-558	63	14	spectramax	spectramax	NOUN
app-558	63	15	plus	plus	CCONJ
app-558	63	16	m5e	m5e	X
app-558	63	17	microplate	microplate	NOUN
app-558	63	18	reader	reader	PROPN
app-558	63	19	.	.	PUNCT
app-558	64	1	morning	morning	NOUN
app-558	64	2	urine	urine	NOUN
app-558	64	3	samples	sample	NOUN
app-558	64	4	from	from	ADP
app-558	64	5	i.d	i.d	PROPN
app-558	64	6	.	.	PROPN
app-558	64	7	subjects	subject	NOUN
app-558	64	8	having	have	VERB
app-558	64	9	risk	risk	NOUN
app-558	64	10	for	for	ADP
app-558	64	11	sialuria	sialuria	PROPN
app-558	64	12	(	(	PUNCT
app-558	64	13	10	10	NUM
app-558	64	14	-	-	SYM
app-558	64	15	13	13	NUM
app-558	64	16	years	year	NOUN
app-558	64	17	of	of	ADP
app-558	64	18	age	age	NOUN
app-558	64	19	)	)	PUNCT
app-558	64	20	were	be	AUX
app-558	64	21	analyzed	analyze	VERB
app-558	64	22	and	and	CCONJ
app-558	64	23	compared	compare	VERB
app-558	64	24	with	with	ADP
app-558	64	25	agematched	agematched	ADJ
app-558	64	26	control	control	NOUN
app-558	64	27	samples	sample	NOUN
app-558	64	28	.	.	PUNCT
app-558	65	1	serial	serial	ADJ
app-558	65	2	dilutions	dilution	NOUN
app-558	65	3	of	of	ADP
app-558	65	4	sialic	sialic	ADJ
app-558	65	5	acid	acid	NOUN
app-558	65	6	standards	standard	NOUN
app-558	65	7	were	be	AUX
app-558	65	8	performed	perform	VERB
app-558	65	9	according	accord	VERB
app-558	65	10	to	to	ADP
app-558	65	11	the	the	DET
app-558	65	12	sialic	sialic	ADJ
app-558	65	13	acid	acid	PROPN
app-558	65	14	assay	assay	PROPN
app-558	65	15	kit	kit	PROPN
app-558	65	16	.	.	PUNCT
app-558	66	1	urine	urine	NOUN
app-558	66	2	samples	sample	NOUN
app-558	66	3	collected	collect	VERB
app-558	66	4	from	from	ADP
app-558	66	5	subjects	subject	NOUN
app-558	66	6	and	and	CCONJ
app-558	66	7	controls	control	NOUN
app-558	66	8	were	be	AUX
app-558	66	9	centrifuged	centrifuge	VERB
app-558	66	10	at	at	ADP
app-558	66	11	3000	3000	NUM
app-558	66	12	rpm	rpm	NOUN
app-558	66	13	for	for	ADP
app-558	66	14	5	5	NUM
app-558	66	15	min	min	NOUN
app-558	66	16	to	to	PART
app-558	66	17	remove	remove	VERB
app-558	66	18	the	the	DET
app-558	66	19	metabolites	metabolite	NOUN
app-558	66	20	.	.	PUNCT
app-558	67	1	real	real	ADJ
app-558	67	2	-	-	PUNCT
app-558	67	3	time	time	NOUN
app-558	67	4	polymerase	polymerase	NOUN
app-558	67	5	chain	chain	NOUN
app-558	67	6	reaction	reaction	NOUN
app-558	67	7	(	(	PUNCT
app-558	67	8	rtqpcr	rtqpcr	ADJ
app-558	67	9	)	)	PUNCT
app-558	67	10	total	total	NOUN
app-558	67	11	rna	rna	NOUN
app-558	67	12	was	be	AUX
app-558	67	13	extracted	extract	VERB
app-558	67	14	from	from	ADP
app-558	67	15	whole	whole	ADJ
app-558	67	16	blood	blood	NOUN
app-558	67	17	(	(	PUNCT
app-558	67	18	500	500	NUM
app-558	67	19	µl	µl	NOUN
app-558	67	20	)	)	PUNCT
app-558	67	21	using	use	VERB
app-558	67	22	a	a	DET
app-558	67	23	whole	whole	ADJ
app-558	67	24	blood	blood	NOUN
app-558	67	25	rna	rna	NOUN
app-558	67	26	purification	purification	NOUN
app-558	67	27	mini	mini	NOUN
app-558	67	28	kit	kit	NOUN
app-558	67	29	(	(	PUNCT
app-558	67	30	thermo	thermo	NOUN
app-558	67	31	scientific	scientific	ADJ
app-558	67	32	genejet	genejet	NOUN
app-558	67	33	cat	cat	NOUN
app-558	67	34	#	#	NOUN
app-558	67	35	k0761	k0761	NOUN
app-558	67	36	)	)	PUNCT
app-558	67	37	.	.	PUNCT
app-558	68	1	the	the	DET
app-558	68	2	quality	quality	NOUN
app-558	68	3	of	of	ADP
app-558	68	4	extracted	extract	VERB
app-558	68	5	rna	rna	NOUN
app-558	68	6	was	be	AUX
app-558	68	7	determined	determine	VERB
app-558	68	8	via	via	ADP
app-558	68	9	a	a	DET
app-558	68	10	spectrophotometer	spectrophotometer	NOUN
app-558	68	11	(	(	PUNCT
app-558	68	12	260/280	260/280	PROPN
app-558	68	13	nm	nm	NOUN
app-558	68	14	)	)	PUNCT
app-558	68	15	.	.	PUNCT
app-558	69	1	according	accord	VERB
app-558	69	2	to	to	ADP
app-558	69	3	the	the	DET
app-558	69	4	manufacturer	manufacturer	NOUN
app-558	69	5	's	's	PART
app-558	69	6	specifications	specification	NOUN
app-558	69	7	,	,	PUNCT
app-558	69	8	total	total	ADJ
app-558	69	9	rna	rna	NOUN
app-558	69	10	was	be	AUX
app-558	69	11	transcribed	transcribe	VERB
app-558	69	12	to	to	ADP
app-558	69	13	cdna	cdna	PROPN
app-558	69	14	using	use	VERB
app-558	69	15	revertaid	revertaid	VERB
app-558	69	16	first	first	ADJ
app-558	69	17	strand	strand	NOUN
app-558	69	18	cdna	cdna	PROPN
app-558	69	19	synthesis	synthesis	NOUN
app-558	69	20	kit	kit	NOUN
app-558	69	21	(	(	PUNCT
app-558	69	22	thermo	thermo	NOUN
app-558	69	23	scientific	scientific	ADJ
app-558	69	24	cat	cat	NOUN
app-558	69	25	#	#	NOUN
app-558	69	26	k1621	k1621	PROPN
app-558	69	27	)	)	PUNCT
app-558	69	28	.	.	PUNCT
app-558	70	1	the	the	DET
app-558	70	2	pcr	pcr	PROPN
app-558	70	3	reaction	reaction	NOUN
app-558	70	4	was	be	AUX
app-558	70	5	initiated	initiate	VERB
app-558	70	6	by	by	ADP
app-558	70	7	an	an	DET
app-558	70	8	incubation	incubation	NOUN
app-558	70	9	step	step	NOUN
app-558	70	10	at	at	ADP
app-558	70	11	25	25	NUM
app-558	70	12	°	°	NOUN
app-558	70	13	c	c	NOUN
app-558	70	14	for	for	ADP
app-558	70	15	5	5	NUM
app-558	70	16	min	min	NOUN
app-558	70	17	,	,	PUNCT
app-558	70	18	followed	follow	VERB
app-558	70	19	by	by	ADP
app-558	70	20	only	only	ADV
app-558	70	21	one	one	NUM
app-558	70	22	cycle	cycle	NOUN
app-558	70	23	of	of	ADP
app-558	70	24	annealing	anneal	VERB
app-558	70	25	step	step	NOUN
app-558	70	26	at	at	ADP
app-558	70	27	42	42	NUM
app-558	70	28	°	°	ADP
app-558	70	29	c	c	NOUN
app-558	70	30	for	for	ADP
app-558	70	31	60	60	NUM
app-558	70	32	min	min	NOUN
app-558	70	33	with	with	ADP
app-558	70	34	a	a	DET
app-558	70	35	termination	termination	NOUN
app-558	70	36	step	step	NOUN
app-558	70	37	at	at	ADP
app-558	70	38	70	70	NUM
app-558	70	39	°	°	ADP
app-558	70	40	c	c	NOUN
app-558	70	41	for	for	ADP
app-558	70	42	5	5	NUM
app-558	70	43	min	min	NOUN
app-558	70	44	.	.	PROPN
app-558	70	45	pcr	pcr	PROPN
app-558	70	46	reaction	reaction	NOUN
app-558	70	47	performed	perform	VERB
app-558	70	48	with	with	ADP
app-558	70	49	an	an	DET
app-558	70	50	abi	abi	PROPN
app-558	70	51	7500	7500	NUM
app-558	70	52	software	software	NOUN
app-558	70	53	v.2.0.6	v.2.0.6	AUX
app-558	70	54	real	real	ADJ
app-558	70	55	-	-	PUNCT
app-558	70	56	time	time	NOUN
app-558	70	57	pcr	pcr	ADJ
app-558	70	58	detection	detection	NOUN
app-558	70	59	system	system	NOUN
app-558	70	60	(	(	PUNCT
app-558	70	61	applied	apply	VERB
app-558	70	62	biosystem	biosystem	PROPN
app-558	70	63	inc	inc	PROPN
app-558	70	64	.	.	PROPN
app-558	70	65	usa	usa	PROPN
app-558	70	66	)	)	PUNCT
app-558	70	67	using	use	VERB
app-558	70	68	the	the	DET
app-558	70	69	maxima	maxima	NOUN
app-558	70	70	sybr	sybr	NOUN
app-558	70	71	green	green	PROPN
app-558	70	72	/	/	SYM
app-558	70	73	rox	rox	PROPN
app-558	70	74	qpcr	qpcr	ADV
app-558	70	75	master	master	NOUN
app-558	70	76	mix	mix	NOUN
app-558	70	77	(	(	PUNCT
app-558	70	78	thermo	thermo	NOUN
app-558	70	79	scientific	scientific	NOUN
app-558	70	80	)	)	PUNCT
app-558	70	81	.	.	PUNCT
app-558	71	1	the	the	DET
app-558	71	2	thermal	thermal	ADJ
app-558	71	3	cycler	cycler	NOUN
app-558	71	4	program	program	NOUN
app-558	71	5	initiated	initiate	VERB
app-558	71	6	by	by	ADP
app-558	71	7	an	an	DET
app-558	71	8	incubating	incubate	VERB
app-558	71	9	step	step	NOUN
app-558	71	10	at	at	ADP
app-558	71	11	95	95	NUM
app-558	71	12	°	°	ADP
app-558	71	13	c	c	NOUN
app-558	71	14	for	for	ADP
app-558	71	15	10	10	NUM
app-558	71	16	min	min	NOUN
app-558	71	17	,	,	PUNCT
app-558	71	18	followed	follow	VERB
app-558	71	19	by	by	ADP
app-558	71	20	40	40	NUM
app-558	71	21	cycles	cycle	NOUN
app-558	71	22	of	of	ADP
app-558	71	23	denaturation	denaturation	NOUN
app-558	71	24	step	step	NOUN
app-558	71	25	at	at	ADP
app-558	71	26	95	95	NUM
app-558	71	27	°	°	ADP
app-558	71	28	c	c	NOUN
app-558	71	29	for	for	ADP
app-558	71	30	15	15	NUM
app-558	71	31	s	s	NOUN
app-558	71	32	,	,	PUNCT
app-558	71	33	annealing	anneal	VERB
app-558	71	34	step	step	NOUN
app-558	71	35	at	at	ADP
app-558	71	36	55	55	NUM
app-558	71	37	°	°	ADP
app-558	71	38	c	c	NOUN
app-558	71	39	for	for	ADP
app-558	71	40	30	30	NUM
app-558	71	41	s	s	NOUN
app-558	71	42	,	,	PUNCT
app-558	71	43	extension	extension	NOUN
app-558	71	44	step	step	NOUN
app-558	71	45	at	at	ADP
app-558	71	46	72	72	NUM
app-558	71	47	°	°	ADP
app-558	71	48	c	c	NOUN
app-558	71	49	for	for	ADP
app-558	71	50	30	30	NUM
app-558	71	51	s	s	NOUN
app-558	71	52	and	and	CCONJ
app-558	71	53	a	a	DET
app-558	71	54	final	final	ADJ
app-558	71	55	extension	extension	NOUN
app-558	71	56	at	at	ADP
app-558	71	57	72	72	NUM
app-558	71	58	°	°	ADP
app-558	71	59	c	c	NOUN
app-558	71	60	for	for	ADP
app-558	71	61	5	5	NUM
app-558	71	62	min	min	NOUN
app-558	71	63	(	(	PUNCT
app-558	71	64	table	table	NOUN
app-558	71	65	1	1	NUM
app-558	71	66	)	)	PUNCT
app-558	71	67	.	.	PUNCT
app-558	72	1	no	no	DET
app-558	72	2	template	template	NOUN
app-558	72	3	control	control	NOUN
app-558	72	4	(	(	PUNCT
app-558	72	5	ntc	ntc	NOUN
app-558	72	6	)	)	PUNCT
app-558	72	7	and	and	CCONJ
app-558	72	8	reverse	reverse	VERB
app-558	72	9	transcriptase	transcriptase	NOUN
app-558	72	10	minus	minus	CCONJ
app-558	72	11	(	(	PUNCT
app-558	72	12	r.t.-	r.t.-	PROPN
app-558	72	13	)	)	PUNCT
app-558	72	14	control	control	NOUN
app-558	72	15	along	along	ADP
app-558	72	16	with	with	ADP
app-558	72	17	pcr	pcr	ADJ
app-558	72	18	analysis	analysis	NOUN
app-558	72	19	was	be	AUX
app-558	72	20	conducted	conduct	VERB
app-558	72	21	in	in	ADP
app-558	72	22	triplicate	triplicate	NOUN
app-558	72	23	for	for	ADP
app-558	72	24	each	each	DET
app-558	72	25	sample	sample	NOUN
app-558	72	26	.	.	PUNCT
app-558	73	1	the	the	DET
app-558	73	2	delta	delta	PROPN
app-558	73	3	delta	delta	PROPN
app-558	73	4	ct	ct	PROPN
app-558	73	5	method	method	NOUN
app-558	73	6	used	use	VERB
app-558	73	7	and	and	CCONJ
app-558	73	8	selected	select	VERB
app-558	73	9	genes	gene	NOUN
app-558	73	10	'	'	PART
app-558	73	11	content	content	NOUN
app-558	73	12	was	be	AUX
app-558	73	13	normalized	normalize	VERB
app-558	73	14	to	to	ADP
app-558	73	15	the	the	DET
app-558	73	16	housekeeping	housekeeping	NOUN
app-558	73	17	gene	gene	NOUN
app-558	73	18	(	(	PUNCT
app-558	73	19	hkg	hkg	PROPN
app-558	73	20	)	)	PUNCT
app-558	73	21	gapdh	gapdh	NOUN
app-558	73	22	.	.	PUNCT
app-558	74	1	the	the	DET
app-558	74	2	calculation	calculation	NOUN
app-558	74	3	was	be	AUX
app-558	74	4	performed	perform	VERB
app-558	74	5	using	use	VERB
app-558	74	6	the	the	DET
app-558	74	7	comparative	comparative	ADJ
app-558	74	8	ct	ct	PROPN
app-558	74	9	method	method	NOUN
app-558	74	10	according	accord	VERB
app-558	74	11	to	to	ADP
app-558	74	12	the	the	DET
app-558	74	13	following	follow	VERB
app-558	74	14	formulas	formula	NOUN
app-558	74	15	:	:	PUNCT
app-558	74	16	δctwt	δctwt	NOUN
app-558	74	17	=	=	SYM
app-558	74	18	ctselected	ctselecte	VERB
app-558	74	19	gene	gene	NOUN
app-558	74	20	wt	wt	NOUN
app-558	74	21	−	−	PROPN
app-558	74	22	cthkg	cthkg	VERB
app-558	74	23	wt	wt	NOUN
app-558	74	24	and	and	CCONJ
app-558	74	25	δctko=	δctko=	NUM
app-558	74	26	ctselected	ctselecte	VERB
app-558	74	27	gene	gene	NOUN
app-558	74	28	ko	ko	PROPN
app-558	74	29	−	−	PROPN
app-558	74	30	cthkg	cthkg	VERB
app-558	74	31	ko	ko	PROPN
app-558	74	32	δδct	δδct	NOUN
app-558	74	33	=	=	NOUN
app-558	74	34	δctko	δctko	NOUN
app-558	74	35	−δctwt	−δctwt	NOUN
app-558	74	36	ratio	ratio	NOUN
app-558	74	37	=	=	SYM
app-558	74	38	2−δδct	2−δδct	NOUN
app-558	74	39	(	(	PUNCT
app-558	74	40	maximum	maximum	ADJ
app-558	74	41	efficacy	efficacy	NOUN
app-558	74	42	is	be	AUX
app-558	74	43	presumed	presume	VERB
app-558	74	44	)	)	PUNCT
app-558	74	45	table	table	NOUN
app-558	74	46	1	1	NUM
app-558	74	47	:	:	PUNCT
app-558	74	48	thermal	thermal	ADJ
app-558	74	49	cycling	cycling	NOUN
app-558	74	50	conditions	condition	NOUN
app-558	74	51	for	for	ADP
app-558	74	52	rt	rt	NOUN
app-558	74	53	-	-	PUNCT
app-558	74	54	qpcr	qpcr	ADJ
app-558	74	55	.	.	PUNCT
app-558	75	1	gene	gene	NOUN
app-558	75	2	primer	primer	NOUN
app-558	75	3	sequence	sequence	NOUN
app-558	75	4	pcr	pcr	NOUN
app-558	75	5	parameters	parameter	NOUN
app-558	75	6	for	for	ADP
app-558	75	7	thermal	thermal	ADJ
app-558	75	8	cycle	cycle	NOUN
app-558	75	9	gne	gne	PROPN
app-558	75	10	mrna	mrna	PROPN
app-558	75	11	gapdh	gapdh	PROPN
app-558	75	12	5´ctccgagttgcaatagtcag	5´ctccgagttgcaatagtcag	NUM
app-558	75	13	3	3	NUM
app-558	75	14	´	´	NOUN
app-558	75	15	(	(	PUNCT
app-558	75	16	f	f	X
app-558	75	17	)	)	PUNCT
app-558	75	18	catccagagacacaacaagg	catccagagacacaacaagg	NOUN
app-558	75	19	(	(	PUNCT
app-558	75	20	r	r	NOUN
app-558	75	21	)	)	PUNCT
app-558	75	22	5´gcatcctgggctacactgag	5´gcatcctgggctacactgag	NUM
app-558	75	23	3	3	NUM
app-558	75	24	´	´	NOUN
app-558	75	25	(	(	PUNCT
app-558	75	26	f	f	X
app-558	75	27	)	)	PUNCT
app-558	75	28	1	1	NUM
app-558	75	29	.	.	PUNCT
app-558	75	30	initial	initial	ADJ
app-558	75	31	temperature______95⁰c	temperature______95⁰c	NOUN
app-558	75	32	for	for	ADP
app-558	75	33	10	10	NUM
app-558	75	34	min	min	NOUN
app-558	75	35	2	2	NUM
app-558	75	36	.	.	PUNCT
app-558	75	37	denaturing	denature	VERB
app-558	75	38	temperature__95⁰c	temperature__95⁰c	NOUN
app-558	75	39	for	for	ADP
app-558	75	40	15	15	NUM
app-558	75	41	sec	sec	PROPN
app-558	75	42	3	3	NUM
app-558	75	43	.	.	PUNCT
app-558	75	44	annealing	anneal	VERB
app-558	75	45	temperature__55⁰c	temperature__55⁰c	NOUN
app-558	75	46	for	for	ADP
app-558	75	47	30	30	NUM
app-558	75	48	sec	sec	PROPN
app-558	75	49	4	4	NUM
app-558	75	50	.	.	PUNCT
app-558	75	51	extension	extension	NOUN
app-558	75	52	temperature__72⁰c	temperature__72⁰c	NOUN
app-558	75	53	for	for	ADP
app-558	75	54	30	30	NUM
app-558	75	55	sec	sec	PROPN
app-558	75	56	5	5	NUM
app-558	75	57	.	.	PUNCT
app-558	75	58	go	go	VERB
app-558	75	59	to	to	PART
app-558	75	60	repeat	repeat	VERB
app-558	75	61	cycle	cycle	NOUN
app-558	75	62	_	_	PUNCT
app-558	76	1	_	_	PUNCT
app-558	77	1	_	_	PUNCT
app-558	78	1	_	_	PUNCT
app-558	79	1	_	_	PUNCT
app-558	80	1	_	_	PUNCT
app-558	81	1	_	_	PUNCT
app-558	82	1	_	_	PUNCT
app-558	83	1	_	_	PUNCT
app-558	83	2	2	2	NUM
app-558	83	3	,	,	PUNCT
app-558	83	4	40	40	NUM
app-558	83	5	times	time	NOUN
app-558	83	6	89	89	NUM
app-558	83	7	issn	issn	PROPN
app-558	83	8	2412	2412	NUM
app-558	83	9	-	-	SYM
app-558	83	10	3188	3188	NUM
app-558	83	11	(	(	PUNCT
app-558	83	12	online	online	NOUN
app-558	83	13	)	)	PUNCT
app-558	83	14	|	|	ADV
app-558	83	15	2410	2410	NUM
app-558	83	16	-	-	SYM
app-558	83	17	1354	1354	NUM
app-558	83	18	(	(	PUNCT
app-558	83	19	print	print	NOUN
app-558	83	20	)	)	PUNCT
app-558	83	21	app|	app|	NOUN
app-558	83	22	published	publish	VERB
app-558	83	23	by	by	ADP
app-558	83	24	aeirc|	aeirc|	ADP
app-558	83	25	volume	volume	NOUN
app-558	83	26	8	8	NUM
app-558	83	27	issue	issue	NOUN
app-558	83	28	2	2	NUM
app-558	83	29	*	*	NOUN
app-558	83	30	thermal	thermal	ADJ
app-558	83	31	cycling	cycling	NOUN
app-558	83	32	conditions	condition	NOUN
app-558	83	33	for	for	ADP
app-558	83	34	rt	rt	NOUN
app-558	83	35	-	-	PUNCT
app-558	83	36	qpcr	qpcr	ADV
app-558	83	37	:	:	PUNCT
app-558	83	38	the	the	DET
app-558	83	39	table	table	NOUN
app-558	83	40	is	be	AUX
app-558	83	41	illustrating	illustrate	VERB
app-558	83	42	thermal	thermal	ADJ
app-558	83	43	cycling	cycling	NOUN
app-558	83	44	conditions	condition	NOUN
app-558	83	45	for	for	ADP
app-558	83	46	rt	rt	NOUN
app-558	83	47	-	-	PUNCT
app-558	83	48	qpcr	qpcr	ADV
app-558	83	49	with	with	ADP
app-558	83	50	gne	gne	PROPN
app-558	83	51	and	and	CCONJ
app-558	83	52	gapdh	gapdh	NOUN
app-558	83	53	primers	primer	NOUN
app-558	83	54	.	.	PUNCT
app-558	84	1	statistical	statistical	ADJ
app-558	84	2	analysis	analysis	NOUN
app-558	84	3	the	the	DET
app-558	84	4	data	datum	NOUN
app-558	84	5	obtained	obtain	VERB
app-558	84	6	in	in	ADP
app-558	84	7	this	this	DET
app-558	84	8	study	study	NOUN
app-558	84	9	were	be	AUX
app-558	84	10	analyzed	analyze	VERB
app-558	84	11	using	use	VERB
app-558	84	12	curve	curve	NOUN
app-558	84	13	expert	expert	NOUN
app-558	84	14	and	and	CCONJ
app-558	84	15	spss	spss	PROPN
app-558	84	16	software	software	PROPN
app-558	84	17	version	version	PROPN
app-558	84	18	17	17	NUM
app-558	84	19	.	.	PUNCT
app-558	85	1	differences	difference	NOUN
app-558	85	2	between	between	ADP
app-558	85	3	the	the	DET
app-558	85	4	mean	mean	ADJ
app-558	85	5	values	value	NOUN
app-558	85	6	of	of	ADP
app-558	85	7	different	different	ADJ
app-558	85	8	groups	group	NOUN
app-558	85	9	were	be	AUX
app-558	85	10	identified	identify	VERB
app-558	85	11	by	by	ADP
app-558	85	12	applying	apply	VERB
app-558	85	13	a	a	DET
app-558	85	14	student	student	NOUN
app-558	85	15	independent	independent	ADJ
app-558	85	16	t	t	PROPN
app-558	85	17	-	-	PUNCT
app-558	85	18	test	test	NOUN
app-558	85	19	.	.	PUNCT
app-558	86	1	each	each	DET
app-558	86	2	experiment	experiment	NOUN
app-558	86	3	was	be	AUX
app-558	86	4	repeated	repeat	VERB
app-558	86	5	three	three	NUM
app-558	86	6	times	time	NOUN
app-558	86	7	.	.	PUNCT
app-558	87	1	the	the	DET
app-558	87	2	correlation	correlation	NOUN
app-558	87	3	between	between	ADP
app-558	87	4	relative	relative	ADJ
app-558	87	5	mrna	mrna	PROPN
app-558	87	6	and	and	CCONJ
app-558	87	7	urinary	urinary	ADJ
app-558	87	8	sialic	sialic	ADJ
app-558	87	9	acid	acid	NOUN
app-558	87	10	levels	level	NOUN
app-558	87	11	was	be	AUX
app-558	87	12	evaluated	evaluate	VERB
app-558	87	13	by	by	ADP
app-558	87	14	using	use	VERB
app-558	87	15	pearson	pearson	PROPN
app-558	87	16	bivariate	bivariate	ADJ
app-558	87	17	correlations	correlation	NOUN
app-558	87	18	.	.	PUNCT
app-558	88	1	p	p	X
app-558	88	2	-	-	PUNCT
app-558	88	3	value	value	NOUN
app-558	88	4	<	<	NOUN
app-558	88	5	0.05	0.05	NUM
app-558	88	6	was	be	AUX
app-558	88	7	considered	consider	VERB
app-558	88	8	significant	significant	ADJ
app-558	88	9	.	.	PUNCT
app-558	89	1	result	result	VERB
app-558	89	2	quantitative	quantitative	ADJ
app-558	89	3	estimation	estimation	NOUN
app-558	89	4	of	of	ADP
app-558	89	5	sialic	sialic	ADJ
app-558	89	6	acid	acid	NOUN
app-558	89	7	in	in	ADP
app-558	89	8	urine	urine	NOUN
app-558	89	9	by	by	ADP
app-558	89	10	fluorometric	fluorometric	ADJ
app-558	89	11	assay	assay	PROPN
app-558	89	12	free	free	ADJ
app-558	89	13	sialic	sialic	ADJ
app-558	89	14	acid	acid	PROPN
app-558	89	15	(	(	PUNCT
app-558	89	16	fsa	fsa	PROPN
app-558	89	17	)	)	PUNCT
app-558	89	18	concentrations	concentration	NOUN
app-558	89	19	(	(	PUNCT
app-558	89	20	table	table	NOUN
app-558	89	21	2	2	NUM
app-558	89	22	)	)	PUNCT
app-558	89	23	from	from	ADP
app-558	89	24	mild	mild	ADJ
app-558	89	25	(	(	PUNCT
app-558	89	26	0.32	0.32	NUM
app-558	89	27	±	±	NUM
app-558	89	28	0.17	0.17	NUM
app-558	89	29	)	)	PUNCT
app-558	89	30	,	,	PUNCT
app-558	89	31	moderate	moderate	ADJ
app-558	89	32	(	(	PUNCT
app-558	89	33	0.07	0.07	NUM
app-558	89	34	±	±	NUM
app-558	89	35	0.03	0.03	NUM
app-558	89	36	)	)	PUNCT
app-558	89	37	and	and	CCONJ
app-558	89	38	severe	severe	ADJ
app-558	89	39	(	(	PUNCT
app-558	89	40	0.04	0.04	NUM
app-558	89	41	±	±	NUM
app-558	89	42	0.01	0.01	NUM
app-558	89	43	)	)	PUNCT
app-558	89	44	intellectually	intellectually	ADV
app-558	89	45	disabled	disabled	ADJ
app-558	89	46	(	(	PUNCT
app-558	89	47	i.d	i.d	PROPN
app-558	89	48	.	.	PROPN
app-558	89	49	)	)	PUNCT
app-558	90	1	subjects	subject	NOUN
app-558	90	2	were	be	AUX
app-558	90	3	used	use	VERB
app-558	90	4	to	to	PART
app-558	90	5	plot	plot	VERB
app-558	90	6	a	a	DET
app-558	90	7	bar	bar	NOUN
app-558	90	8	diagram	diagram	NOUN
app-558	90	9	(	(	PUNCT
app-558	90	10	figure1	figure1	PROPN
app-558	90	11	)	)	PUNCT
app-558	90	12	.	.	PUNCT
app-558	91	1	the	the	DET
app-558	91	2	result	result	NOUN
app-558	91	3	illustrates	illustrate	VERB
app-558	91	4	an	an	DET
app-558	91	5	average	average	ADJ
app-558	91	6	two	two	NUM
app-558	91	7	-	-	ADJ
app-558	91	8	fold	fold	ADJ
app-558	91	9	increase	increase	NOUN
app-558	91	10	in	in	ADP
app-558	91	11	sialic	sialic	ADJ
app-558	91	12	acid	acid	NOUN
app-558	91	13	levels	level	NOUN
app-558	91	14	in	in	ADP
app-558	91	15	mild	mild	ADJ
app-558	91	16	i.d	i.d	PROPN
app-558	91	17	.	.	PROPN
app-558	91	18	subjects	subject	NOUN
app-558	91	19	.	.	PUNCT
app-558	92	1	however	however	ADV
app-558	92	2	,	,	PUNCT
app-558	92	3	the	the	DET
app-558	92	4	levels	level	NOUN
app-558	92	5	were	be	AUX
app-558	92	6	not	not	PART
app-558	92	7	significant	significant	ADJ
app-558	92	8	when	when	SCONJ
app-558	92	9	compared	compare	VERB
app-558	92	10	to	to	ADP
app-558	92	11	controls	control	NOUN
app-558	92	12	.	.	PUNCT
app-558	93	1	in	in	ADP
app-558	93	2	contrast	contrast	NOUN
app-558	93	3	,	,	PUNCT
app-558	93	4	there	there	PRON
app-558	93	5	was	be	VERB
app-558	93	6	a	a	DET
app-558	93	7	significant	significant	ADJ
app-558	93	8	decrease	decrease	NOUN
app-558	93	9	in	in	ADP
app-558	93	10	the	the	DET
app-558	93	11	sialic	sialic	ADJ
app-558	93	12	acid	acid	NOUN
app-558	93	13	levels	level	NOUN
app-558	93	14	found	find	VERB
app-558	93	15	in	in	ADP
app-558	93	16	the	the	DET
app-558	93	17	severely	severely	ADV
app-558	93	18	intellectually	intellectually	ADV
app-558	93	19	disabled	disabled	ADJ
app-558	93	20	subjects	subject	NOUN
app-558	93	21	compared	compare	VERB
app-558	93	22	to	to	ADP
app-558	93	23	controls	control	NOUN
app-558	93	24	.	.	PUNCT
app-558	94	1	fluorometric	fluorometric	ADJ
app-558	94	2	assay	assay	NOUN
app-558	94	3	is	be	AUX
app-558	94	4	used	use	VERB
app-558	94	5	to	to	PART
app-558	94	6	quantify	quantify	VERB
app-558	94	7	urinary	urinary	ADJ
app-558	94	8	free	free	ADJ
app-558	94	9	sialic	sialic	ADJ
app-558	94	10	acid	acid	PROPN
app-558	94	11	(	(	PUNCT
app-558	94	12	fsa	fsa	PROPN
app-558	94	13	)	)	PUNCT
app-558	94	14	levels	level	NOUN
app-558	94	15	in	in	ADP
app-558	94	16	i	i	PROPN
app-558	94	17	d	d	PROPN
app-558	94	18	patients	patient	NOUN
app-558	94	19	.	.	PUNCT
app-558	95	1	the	the	DET
app-558	95	2	table	table	NOUN
app-558	95	3	depicts	depict	VERB
app-558	95	4	no	no	DET
app-558	95	5	significant	significant	ADJ
app-558	95	6	differences	difference	NOUN
app-558	95	7	in	in	ADP
app-558	95	8	sialic	sialic	ADJ
app-558	95	9	acid	acid	NOUN
app-558	95	10	levels	level	NOUN
app-558	95	11	in	in	ADP
app-558	95	12	mild	mild	ADJ
app-558	95	13	and	and	CCONJ
app-558	95	14	moderate	moderate	ADJ
app-558	96	1	i	i	PROPN
app-558	96	2	d.	d.	PROPN
app-558	96	3	patients	patient	NOUN
app-558	96	4	.	.	PUNCT
app-558	97	1	however	however	ADV
app-558	97	2	,	,	PUNCT
app-558	97	3	there	there	PRON
app-558	97	4	was	be	VERB
app-558	97	5	a	a	DET
app-558	97	6	two	two	NUM
app-558	97	7	-	-	ADJ
app-558	97	8	fold	fold	ADJ
app-558	97	9	increase	increase	NOUN
app-558	97	10	in	in	ADP
app-558	97	11	the	the	DET
app-558	97	12	levels	level	NOUN
app-558	97	13	of	of	ADP
app-558	97	14	sialic	sialic	ADJ
app-558	97	15	acid	acid	NOUN
app-558	97	16	in	in	ADP
app-558	97	17	mild	mild	ADJ
app-558	97	18	i	i	PRON
app-558	97	19	d.	d.	PROPN
app-558	97	20	and	and	CCONJ
app-558	97	21	a	a	DET
app-558	97	22	significant	significant	ADJ
app-558	97	23	reduction	reduction	NOUN
app-558	97	24	in	in	ADP
app-558	97	25	the	the	DET
app-558	97	26	free	free	ADJ
app-558	97	27	sialic	sialic	ADJ
app-558	97	28	acid	acid	NOUN
app-558	97	29	levels	level	NOUN
app-558	97	30	in	in	ADP
app-558	97	31	severe	severe	ADJ
app-558	97	32	i	i	PROPN
app-558	97	33	d	d	PROPN
app-558	97	34	patients	patient	NOUN
app-558	97	35	compared	compare	VERB
app-558	97	36	to	to	ADP
app-558	97	37	controls	control	NOUN
app-558	97	38	.	.	PUNCT
app-558	98	1	statistical	statistical	ADJ
app-558	98	2	analysis	analysis	NOUN
app-558	98	3	was	be	AUX
app-558	98	4	revealed	reveal	VERB
app-558	98	5	by	by	ADP
app-558	98	6	two	two	NUM
app-558	98	7	independent	independent	ADJ
app-558	98	8	t	t	NOUN
app-558	98	9	-	-	PUNCT
app-558	98	10	test	test	NOUN
app-558	98	11	.	.	PUNCT
app-558	99	1	means	mean	VERB
app-558	99	2	values	value	NOUN
app-558	99	3	are	be	AUX
app-558	99	4	±	±	NUM
app-558	99	5	s.d	s.d	PROPN
app-558	99	6	.	.	PUNCT
app-558	99	7	p<0.05	p<0.05	PROPN
app-558	99	8	was	be	AUX
app-558	99	9	considered	consider	VERB
app-558	99	10	significant	significant	ADJ
app-558	99	11	.	.	PUNCT
app-558	100	1	table	table	NOUN
app-558	100	2	2	2	NUM
app-558	100	3	:	:	PUNCT
app-558	100	4	fluorometric	fluorometric	ADV
app-558	100	5	assay	assay	VERB
app-558	100	6	to	to	PART
app-558	100	7	quantify	quantify	VERB
app-558	100	8	urinary	urinary	ADJ
app-558	100	9	free	free	ADJ
app-558	100	10	sialic	sialic	ADJ
app-558	100	11	acid	acid	PROPN
app-558	100	12	(	(	PUNCT
app-558	100	13	fsa	fsa	PROPN
app-558	100	14	)	)	PUNCT
app-558	100	15	levels	level	NOUN
app-558	100	16	.	.	PUNCT
app-558	101	1	symptom	symptom	NOUN
app-558	101	2	severity	severity	NOUN
app-558	101	3	age	age	NOUN
app-558	101	4	(	(	PUNCT
app-558	101	5	years	year	NOUN
app-558	101	6	)	)	PUNCT
app-558	101	7	free	free	ADJ
app-558	101	8	sialic	sialic	ADJ
app-558	101	9	acid	acid	PROPN
app-558	101	10	(	(	PUNCT
app-558	101	11	fsa	fsa	PROPN
app-558	101	12	)	)	PUNCT
app-558	101	13	concentration	concentration	NOUN
app-558	101	14	in	in	ADP
app-558	101	15	urine	urine	NOUN
app-558	101	16	µl	µl	NOUN
app-558	101	17	)	)	PUNCT
app-558	101	18	p	p	NOUN
app-558	101	19	-	-	PUNCT
app-558	101	20	value	value	NOUN
app-558	101	21	(	(	PUNCT
app-558	101	22	means	mean	VERB
app-558	101	23	±	±	PROPN
app-558	101	24	s.d	s.d	PROPN
app-558	101	25	.	.	PROPN
app-558	101	26	)	)	PUNCT
app-558	102	1	controls	control	VERB
app-558	102	2	subjects	subject	NOUN
app-558	102	3	controls	control	VERB
app-558	102	4	10	10	NUM
app-558	102	5	-	-	SYM
app-558	102	6	13	13	NUM
app-558	102	7	mild	mild	ADJ
app-558	102	8	i	i	NOUN
app-558	102	9	d	d	PROPN
app-558	102	10	10	10	NUM
app-558	102	11	0.16±0.13	0.16±0.13	VERB
app-558	102	12	0.32±0.17	0.32±0.17	NOUN
app-558	102	13	<	<	X
app-558	102	14	0.0005	0.0005	NUM
app-558	102	15	moderate	moderate	ADJ
app-558	103	1	i	i	PROPN
app-558	103	2	d	d	PROPN
app-558	103	3	11	11	NUM
app-558	103	4	0.07±0.03	0.07±0.03	NOUN
app-558	103	5	<	<	X
app-558	103	6	0.0005	0.0005	NUM
app-558	103	7	severe	severe	ADJ
app-558	103	8	i	i	PROPN
app-558	103	9	d	d	PROPN
app-558	103	10	13	13	NUM
app-558	103	11	0.04±0.007	0.04±0.007	PUNCT
app-558	103	12	<	<	X
app-558	103	13	0.0005	0.0005	NUM
app-558	103	14	5´ttgccctcaacgaccacttt	5´ttgccctcaacgaccacttt	NUM
app-558	103	15	3	3	NUM
app-558	103	16	´	´	NOUN
app-558	103	17	(	(	PUNCT
app-558	103	18	r	r	NOUN
app-558	103	19	)	)	PUNCT
app-558	103	20	6	6	NUM
app-558	103	21	.	.	PUNCT
app-558	103	22	final	final	ADJ
app-558	103	23	extension	extension	NOUN
app-558	103	24	temperature___72⁰c	temperature___72⁰c	NOUN
app-558	103	25	for	for	ADP
app-558	103	26	5	5	NUM
app-558	103	27	min	min	NOUN
app-558	103	28	7	7	NUM
app-558	103	29	.	.	PUNCT
app-558	103	30	hold	hold	VERB
app-558	103	31	on	on	ADP
app-558	103	32	_	_	PUNCT
app-558	103	33	_	_	PUNCT
app-558	104	1	_	_	PUNCT
app-558	105	1	_	_	PUNCT
app-558	106	1	_	_	PUNCT
app-558	107	1	_	_	PUNCT
app-558	108	1	_	_	PUNCT
app-558	109	1	_	_	PUNCT
app-558	110	1	_	_	PUNCT
app-558	111	1	_	_	PUNCT
app-558	112	1	_	_	PUNCT
app-558	113	1	_	_	PUNCT
app-558	114	1	_	_	PUNCT
app-558	115	1	_	_	PUNCT
app-558	116	1	_	_	PUNCT
app-558	117	1	_	_	PUNCT
app-558	118	1	_	_	PUNCT
app-558	118	2	4⁰c	4⁰c	PUNCT
app-558	118	3	forever	forever	ADV
app-558	118	4	90	90	NUM
app-558	118	5	issn	issn	PROPN
app-558	118	6	2412	2412	NUM
app-558	118	7	-	-	SYM
app-558	118	8	3188	3188	NUM
app-558	118	9	(	(	PUNCT
app-558	118	10	online	online	NOUN
app-558	118	11	)	)	PUNCT
app-558	118	12	|	|	ADV
app-558	118	13	2410	2410	NUM
app-558	118	14	-	-	SYM
app-558	118	15	1354	1354	NUM
app-558	118	16	(	(	PUNCT
app-558	118	17	print	print	NOUN
app-558	118	18	)	)	PUNCT
app-558	118	19	app|	app|	NOUN
app-558	118	20	published	publish	VERB
app-558	118	21	by	by	ADP
app-558	118	22	aeirc|	aeirc|	ADP
app-558	118	23	volume	volume	NOUN
app-558	118	24	8	8	NUM
app-558	118	25	issue	issue	NOUN
app-558	118	26	2	2	NUM
app-558	118	27	figure	figure	NOUN
app-558	118	28	1	1	NUM
app-558	118	29	:	:	PUNCT
app-558	118	30	sialic	sialic	ADJ
app-558	118	31	acid	acid	NOUN
app-558	118	32	levels	level	NOUN
app-558	118	33	in	in	ADP
app-558	118	34	the	the	DET
app-558	118	35	urine	urine	NOUN
app-558	118	36	controls	control	NOUN
app-558	118	37	and	and	CCONJ
app-558	118	38	patients	patient	NOUN
app-558	118	39	from	from	ADP
app-558	118	40	pakistan	pakistan	PROPN
app-558	118	41	.	.	PUNCT
app-558	119	1	the	the	DET
app-558	119	2	bar	bar	NOUN
app-558	119	3	diagram	diagram	NOUN
app-558	119	4	shows	show	VERB
app-558	119	5	the	the	DET
app-558	119	6	comparison	comparison	NOUN
app-558	119	7	of	of	ADP
app-558	119	8	sialic	sialic	ADJ
app-558	119	9	acid	acid	NOUN
app-558	119	10	levels	level	NOUN
app-558	119	11	among	among	ADP
app-558	119	12	controls	control	NOUN
app-558	119	13	and	and	CCONJ
app-558	119	14	i	i	PROPN
app-558	119	15	d	d	PROPN
app-558	119	16	patients	patient	NOUN
app-558	119	17	.	.	PUNCT
app-558	120	1	a	a	DET
app-558	120	2	significant	significant	ADJ
app-558	120	3	difference	difference	NOUN
app-558	120	4	was	be	AUX
app-558	120	5	observed	observe	VERB
app-558	120	6	in	in	ADP
app-558	120	7	patients	patient	NOUN
app-558	120	8	with	with	ADP
app-558	120	9	severe	severe	ADJ
app-558	120	10	i	i	PROPN
app-558	120	11	d.	d.	PROPN
app-558	120	12	significant	significant	ADJ
app-558	120	13	differences	difference	NOUN
app-558	120	14	were	be	AUX
app-558	120	15	evaluated	evaluate	VERB
app-558	120	16	by	by	ADP
app-558	120	17	a	a	DET
app-558	120	18	two	two	NUM
app-558	120	19	-	-	PUNCT
app-558	120	20	tailed	tail	VERB
app-558	120	21	t	t	NOUN
app-558	120	22	-	-	PUNCT
app-558	120	23	test	test	NOUN
app-558	120	24	(	(	PUNCT
app-558	120	25	*	*	PUNCT
app-558	120	26	p	p	X
app-558	120	27	<	<	X
app-558	120	28	0.0005	0.0005	NUM
app-558	120	29	)	)	PUNCT
app-558	120	30	.	.	PUNCT
app-558	121	1	gne	gne	PROPN
app-558	121	2	mrna	mrna	PROPN
app-558	121	3	expression	expression	NOUN
app-558	121	4	levels	level	NOUN
app-558	121	5	the	the	DET
app-558	121	6	gne	gne	PROPN
app-558	121	7	gene	gene	NOUN
app-558	121	8	expression	expression	NOUN
app-558	121	9	in	in	ADP
app-558	121	10	subjects	subject	NOUN
app-558	121	11	with	with	ADP
app-558	121	12	severe	severe	ADJ
app-558	121	13	i	i	PROPN
app-558	121	14	d	d	PROPN
app-558	121	15	and	and	CCONJ
app-558	121	16	controls	control	NOUN
app-558	121	17	was	be	AUX
app-558	121	18	quantified	quantify	VERB
app-558	121	19	concerning	concern	VERB
app-558	121	20	the	the	DET
app-558	121	21	housekeeping	housekeeping	NOUN
app-558	121	22	gene	gene	NOUN
app-558	121	23	gapdh	gapdh	NOUN
app-558	121	24	.	.	PUNCT
app-558	122	1	the	the	DET
app-558	122	2	results	result	NOUN
app-558	122	3	show	show	VERB
app-558	122	4	a	a	DET
app-558	122	5	significant	significant	ADJ
app-558	122	6	down	down	NOUN
app-558	122	7	-	-	PUNCT
app-558	122	8	regulation	regulation	NOUN
app-558	122	9	in	in	ADP
app-558	122	10	the	the	DET
app-558	122	11	expression	expression	NOUN
app-558	122	12	of	of	ADP
app-558	122	13	gne	gne	PROPN
app-558	122	14	gene	gene	NOUN
app-558	122	15	levels	level	NOUN
app-558	122	16	in	in	ADP
app-558	122	17	subjects	subject	NOUN
app-558	122	18	with	with	ADP
app-558	122	19	severe	severe	ADJ
app-558	122	20	(	(	PUNCT
app-558	122	21	p<0.003	p<0.003	NOUN
app-558	122	22	)	)	PUNCT
app-558	122	23	i	i	NOUN
app-558	122	24	d	d	NOUN
app-558	122	25	when	when	SCONJ
app-558	122	26	compared	compare	VERB
app-558	122	27	to	to	ADP
app-558	122	28	controls	control	NOUN
app-558	122	29	(	(	PUNCT
app-558	122	30	figure	figure	NOUN
app-558	122	31	2	2	NUM
app-558	122	32	)	)	PUNCT
app-558	122	33	.	.	PUNCT
app-558	123	1	figure	figure	VERB
app-558	123	2	2	2	NUM
app-558	123	3	:	:	PUNCT
app-558	123	4	relative	relative	ADJ
app-558	123	5	expression	expression	NOUN
app-558	123	6	levels	level	NOUN
app-558	123	7	of	of	ADP
app-558	123	8	the	the	DET
app-558	123	9	gne	gne	PROPN
app-558	123	10	gene	gene	NOUN
app-558	123	11	by	by	ADP
app-558	123	12	real	real	ADJ
app-558	123	13	-	-	PUNCT
app-558	123	14	time	time	NOUN
app-558	123	15	quantitative	quantitative	ADJ
app-558	123	16	pcr	pcr	NOUN
app-558	123	17	.	.	PUNCT
app-558	124	1	bar	bar	NOUN
app-558	124	2	graph	graph	NOUN
app-558	124	3	representing	represent	VERB
app-558	124	4	the	the	DET
app-558	124	5	fold	fold	ADJ
app-558	124	6	changes	change	NOUN
app-558	124	7	of	of	ADP
app-558	124	8	gne	gne	PROPN
app-558	124	9	mrna	mrna	PROPN
app-558	124	10	levels	level	NOUN
app-558	124	11	quantified	quantify	VERB
app-558	124	12	by	by	ADP
app-558	124	13	normalization	normalization	NOUN
app-558	124	14	to	to	ADP
app-558	124	15	the	the	DET
app-558	124	16	gapdh	gapdh	NOUN
app-558	124	17	as	as	ADP
app-558	124	18	an	an	DET
app-558	124	19	internal	internal	ADJ
app-558	124	20	control	control	NOUN
app-558	124	21	.	.	PUNCT
app-558	125	1	mild	mild	ADJ
app-558	125	2	,	,	PUNCT
app-558	125	3	moderate	moderate	ADJ
app-558	125	4	,	,	PUNCT
app-558	125	5	and	and	CCONJ
app-558	125	6	severe	severe	ADJ
app-558	125	7	i	i	PROPN
app-558	125	8	d.	d.	PROPN
app-558	125	9	patients	patient	NOUN
app-558	125	10	showed	show	VERB
app-558	125	11	down	down	ADP
app-558	125	12	-	-	PUNCT
app-558	125	13	regulation	regulation	NOUN
app-558	125	14	in	in	ADP
app-558	125	15	the	the	DET
app-558	125	16	gne	gne	PROPN
app-558	125	17	gene	gene	NOUN
app-558	125	18	expression	expression	NOUN
app-558	125	19	compared	compare	VERB
app-558	125	20	to	to	ADP
app-558	125	21	controls	control	NOUN
app-558	125	22	.	.	PUNCT
app-558	126	1	however	however	ADV
app-558	126	2	,	,	PUNCT
app-558	126	3	mild	mild	ADJ
app-558	126	4	and	and	CCONJ
app-558	126	5	moderate	moderate	ADJ
app-558	126	6	i	i	PRON
app-558	126	7	d.	d.	PROPN
app-558	126	8	patients	patient	NOUN
app-558	126	9	showed	show	VERB
app-558	126	10	2and	2and	NUM
app-558	126	11	0.5	0.5	NUM
app-558	126	12	-	-	NUM
app-558	126	13	fold	fold	VERB
app-558	126	14	up	up	ADP
app-558	126	15	-	-	PUNCT
app-558	126	16	regulation	regulation	NOUN
app-558	126	17	compared	compare	VERB
app-558	126	18	to	to	ADP
app-558	126	19	severe	severe	ADJ
app-558	126	20	i	i	PROPN
app-558	126	21	d.	d.	PROPN
app-558	126	22	patients	patient	NOUN
app-558	126	23	,	,	PUNCT
app-558	126	24	respectively	respectively	ADV
app-558	126	25	.	.	PUNCT
app-558	127	1	91	91	NUM
app-558	127	2	issn	issn	VERB
app-558	127	3	2412	2412	NUM
app-558	127	4	-	-	SYM
app-558	127	5	3188	3188	NUM
app-558	127	6	(	(	PUNCT
app-558	127	7	online	online	NOUN
app-558	127	8	)	)	PUNCT
app-558	127	9	|	|	ADV
app-558	127	10	2410	2410	NUM
app-558	127	11	-	-	SYM
app-558	127	12	1354	1354	NUM
app-558	127	13	(	(	PUNCT
app-558	127	14	print	print	NOUN
app-558	127	15	)	)	PUNCT
app-558	127	16	app|	app|	NOUN
app-558	127	17	published	publish	VERB
app-558	127	18	by	by	ADP
app-558	127	19	aeirc|	aeirc|	ADP
app-558	127	20	volume	volume	NOUN
app-558	127	21	8	8	NUM
app-558	127	22	issue	issue	NOUN
app-558	127	23	2	2	NUM
app-558	127	24	significant	significant	ADJ
app-558	127	25	differences	difference	NOUN
app-558	127	26	were	be	AUX
app-558	127	27	evaluated	evaluate	VERB
app-558	127	28	by	by	ADP
app-558	127	29	an	an	DET
app-558	127	30	independent	independent	ADJ
app-558	127	31	t	t	NOUN
app-558	127	32	-	-	PUNCT
app-558	127	33	test	test	NOUN
app-558	127	34	(	(	PUNCT
app-558	127	35	*	*	PUNCT
app-558	127	36	*	*	PUNCT
app-558	127	37	p	p	X
app-558	127	38	<	<	X
app-558	127	39	0.01	0.01	NUM
app-558	127	40	,	,	PUNCT
app-558	127	41	*	*	PUNCT
app-558	127	42	*	*	PUNCT
app-558	127	43	*	*	NOUN
app-558	127	44	p<0.003	p<0.003	NOUN
app-558	127	45	)	)	PUNCT
app-558	127	46	.	.	PUNCT
app-558	128	1	significant	significant	ADJ
app-558	128	2	correlation	correlation	NOUN
app-558	128	3	was	be	AUX
app-558	128	4	found	find	VERB
app-558	128	5	between	between	ADP
app-558	128	6	gne	gne	PROPN
app-558	128	7	mrna	mrna	PROPN
app-558	128	8	and	and	CCONJ
app-558	128	9	sialic	sialic	ADJ
app-558	128	10	acid	acid	NOUN
app-558	128	11	levels	level	NOUN
app-558	128	12	of	of	ADP
app-558	128	13	severe	severe	ADJ
app-558	128	14	i	i	PROPN
app-558	128	15	d	d	PROPN
app-558	128	16	patients	patient	NOUN
app-558	128	17	(	(	PUNCT
app-558	128	18	0.048	0.048	NUM
app-558	128	19	±	±	NUM
app-558	128	20	0.0076	0.0076	NUM
app-558	128	21	)	)	PUNCT
app-558	128	22	(	(	PUNCT
app-558	128	23	p=	p=	PROPN
app-558	128	24	0.021	0.021	NUM
app-558	128	25	)	)	PUNCT
app-558	128	26	.	.	PUNCT
app-558	129	1	discussion	discussion	NOUN
app-558	129	2	previously	previously	ADV
app-558	129	3	we	we	PRON
app-558	129	4	have	have	AUX
app-558	129	5	identified	identify	VERB
app-558	129	6	g	g	PROPN
app-558	129	7	/	/	SYM
app-558	129	8	a	a	DET
app-558	129	9	substitution	substitution	NOUN
app-558	129	10	(	(	PUNCT
app-558	129	11	r263q	r263q	ADJ
app-558	129	12	)	)	PUNCT
app-558	129	13	mutations	mutation	NOUN
app-558	129	14	in	in	ADP
app-558	129	15	snp	snp	ADJ
app-558	129	16	:	:	PUNCT
app-558	129	17	rs121908623	rs121908623	PROPN
app-558	129	18	of	of	ADP
app-558	129	19	the	the	DET
app-558	129	20	gne	gne	PROPN
app-558	129	21	gene	gene	NOUN
app-558	129	22	in	in	ADP
app-558	129	23	the	the	DET
app-558	129	24	pakistani	pakistani	ADJ
app-558	129	25	population5	population5	PROPN
app-558	129	26	.	.	PUNCT
app-558	130	1	as	as	SCONJ
app-558	130	2	sialuria	sialuria	PROPN
app-558	130	3	is	be	AUX
app-558	130	4	a	a	DET
app-558	130	5	very	very	ADV
app-558	130	6	rare	rare	ADJ
app-558	130	7	disorder	disorder	NOUN
app-558	130	8	,	,	PUNCT
app-558	130	9	up	up	ADV
app-558	130	10	till	till	SCONJ
app-558	130	11	now	now	ADV
app-558	130	12	,	,	PUNCT
app-558	130	13	only	only	ADV
app-558	130	14	10	10	NUM
app-558	130	15	ten	ten	NUM
app-558	130	16	patients	patient	NOUN
app-558	130	17	have	have	AUX
app-558	130	18	been	be	AUX
app-558	130	19	reported	report	VERB
app-558	130	20	worldwide	worldwide	ADV
app-558	130	21	.	.	PUNCT
app-558	131	1	the	the	DET
app-558	131	2	first	first	ADJ
app-558	131	3	patient	patient	NOUN
app-558	131	4	was	be	AUX
app-558	131	5	identified	identify	VERB
app-558	131	6	in	in	ADP
app-558	131	7	1968	1968	NUM
app-558	131	8	by	by	ADP
app-558	131	9	(	(	PUNCT
app-558	131	10	a	a	NOUN
app-558	131	11	)	)	PUNCT
app-558	131	12	,	,	PUNCT
app-558	131	13	and	and	CCONJ
app-558	131	14	the	the	DET
app-558	131	15	tenth	tenth	ADJ
app-558	131	16	patient	patient	NOUN
app-558	131	17	was	be	AUX
app-558	131	18	identified	identify	VERB
app-558	131	19	by	by	ADP
app-558	131	20	ishtiaq	ishtiaq	NOUN
app-558	131	21	and	and	CCONJ
app-558	131	22	colleagues	colleague	NOUN
app-558	131	23	(	(	PUNCT
app-558	131	24	2020	2020	NUM
app-558	131	25	)	)	PUNCT
app-558	131	26	.	.	PUNCT
app-558	132	1	in	in	ADP
app-558	132	2	all	all	PRON
app-558	132	3	of	of	ADP
app-558	132	4	the	the	DET
app-558	132	5	patients	patient	NOUN
app-558	132	6	,	,	PUNCT
app-558	132	7	the	the	DET
app-558	132	8	symptoms	symptom	NOUN
app-558	132	9	were	be	AUX
app-558	132	10	similar	similar	ADJ
app-558	132	11	such	such	ADJ
app-558	132	12	as	as	ADP
app-558	132	13	jaundice	jaundice	NOUN
app-558	132	14	,	,	PUNCT
app-558	132	15	low	low	ADJ
app-558	132	16	birth	birth	NOUN
app-558	132	17	weight	weight	NOUN
app-558	132	18	,	,	PUNCT
app-558	132	19	coarse	coarse	ADJ
app-558	132	20	facies	facie	NOUN
app-558	132	21	,	,	PUNCT
app-558	132	22	hepatomegaly	hepatomegaly	NOUN
app-558	132	23	,	,	PUNCT
app-558	132	24	seizures	seizure	NOUN
app-558	132	25	;	;	PUNCT
app-558	132	26	however	however	ADV
app-558	132	27	,	,	PUNCT
app-558	132	28	they	they	PRON
app-558	132	29	had	have	VERB
app-558	132	30	normal	normal	ADJ
app-558	132	31	birth	birth	NOUN
app-558	132	32	and	and	CCONJ
app-558	132	33	delivery5	delivery5	PROPN
app-558	132	34	.	.	PUNCT
app-558	133	1	besides	besides	SCONJ
app-558	133	2	this	this	PRON
app-558	133	3	,	,	PUNCT
app-558	133	4	the	the	DET
app-558	133	5	neurological	neurological	ADJ
app-558	133	6	symptoms	symptom	NOUN
app-558	133	7	included	include	VERB
app-558	133	8	speech	speech	NOUN
app-558	133	9	and	and	CCONJ
app-558	133	10	motor	motor	NOUN
app-558	133	11	impairments	impairment	NOUN
app-558	133	12	.	.	PUNCT
app-558	134	1	all	all	DET
app-558	134	2	these	these	DET
app-558	134	3	patients	patient	NOUN
app-558	134	4	had	have	VERB
app-558	134	5	mutations	mutation	NOUN
app-558	134	6	in	in	ADP
app-558	134	7	the	the	DET
app-558	134	8	gne	gne	PROPN
app-558	134	9	gene	gene	NOUN
app-558	134	10	at	at	ADP
app-558	134	11	g→t	g→t	PRON
app-558	134	12	:	:	PUNCT
app-558	134	13	849	849	NUM
app-558	134	14	,	,	PUNCT
app-558	134	15	g→a:848	g→a:848	PROPN
app-558	134	16	,	,	PUNCT
app-558	134	17	g→t:839	g→t:839	PROPN
app-558	134	18	,	,	PUNCT
app-558	134	19	g→a:839	g→a:839	NOUN
app-558	134	20	,	,	PUNCT
app-558	134	21	g→c:250	g→c:250	PROPN
app-558	134	22	,	,	PUNCT
app-558	134	23	t→c:51	t→c:51	ADP
app-558	134	24	+	+	ADJ
app-558	134	25	34	34	NUM
app-558	134	26	positions6	positions6	NOUN
app-558	134	27	-	-	PUNCT
app-558	134	28	15	15	NUM
app-558	134	29	.	.	PUNCT
app-558	135	1	recent	recent	ADJ
app-558	135	2	works	work	NOUN
app-558	135	3	on	on	ADP
app-558	135	4	sialuria	sialuria	PROPN
app-558	135	5	presented	present	VERB
app-558	135	6	a	a	DET
app-558	135	7	link	link	NOUN
app-558	135	8	between	between	ADP
app-558	135	9	intellectual	intellectual	ADJ
app-558	135	10	disability	disability	NOUN
app-558	135	11	with	with	ADP
app-558	135	12	low	low	ADJ
app-558	135	13	household	household	NOUN
app-558	135	14	income	income	NOUN
app-558	135	15	,	,	PUNCT
app-558	135	16	low	low	ADJ
app-558	135	17	maternal	maternal	ADJ
app-558	135	18	education	education	NOUN
app-558	135	19	,	,	PUNCT
app-558	135	20	and	and	CCONJ
app-558	135	21	consanguinity	consanguinity	NOUN
app-558	135	22	marriages16	marriages16	PROPN
app-558	135	23	.	.	PUNCT
app-558	136	1	sialic	sialic	ADJ
app-558	136	2	acids	acid	NOUN
app-558	136	3	are	be	AUX
app-558	136	4	negatively	negatively	ADV
app-558	136	5	charged	charge	VERB
app-558	136	6	amino	amino	NOUN
app-558	136	7	sugars	sugar	NOUN
app-558	136	8	and	and	CCONJ
app-558	136	9	are	be	AUX
app-558	136	10	added	add	VERB
app-558	136	11	to	to	ADP
app-558	136	12	many	many	ADJ
app-558	136	13	glycoproteins	glycoprotein	NOUN
app-558	136	14	during	during	ADP
app-558	136	15	posttranslational	posttranslational	ADJ
app-558	136	16	modifications	modification	NOUN
app-558	136	17	of	of	ADP
app-558	136	18	proteins	protein	NOUN
app-558	136	19	.	.	PUNCT
app-558	137	1	due	due	ADP
app-558	137	2	to	to	ADP
app-558	137	3	this	this	PRON
app-558	137	4	,	,	PUNCT
app-558	137	5	they	they	PRON
app-558	137	6	actively	actively	ADV
app-558	137	7	participate	participate	VERB
app-558	137	8	in	in	ADP
app-558	137	9	biological	biological	ADJ
app-558	137	10	molecular	molecular	ADJ
app-558	137	11	interactions17	interactions17	NOUN
app-558	137	12	.	.	PUNCT
app-558	138	1	structural	structural	ADJ
app-558	138	2	data	datum	NOUN
app-558	138	3	of	of	ADP
app-558	138	4	gne	gne	PROPN
app-558	138	5	/	/	SYM
app-558	138	6	mnk	mnk	PROPN
app-558	138	7	homolog	homolog	PROPN
app-558	138	8	have	have	AUX
app-558	138	9	developed	develop	VERB
app-558	138	10	by	by	ADP
app-558	138	11	kurochkina	kurochkina	PROPN
app-558	138	12	,	,	PUNCT
app-558	138	13	yardeni	yardeni	ADJ
app-558	138	14	,	,	PUNCT
app-558	138	15	and	and	CCONJ
app-558	138	16	huizing	huize	VERB
app-558	138	17	(	(	PUNCT
app-558	138	18	2010	2010	NUM
app-558	138	19	)	)	PUNCT
app-558	138	20	that	that	PRON
app-558	138	21	exposes	expose	VERB
app-558	138	22	critical	critical	ADJ
app-558	138	23	substrate	substrate	NOUN
app-558	138	24	binding	bind	VERB
app-558	138	25	sites	site	NOUN
app-558	138	26	on	on	ADP
app-558	138	27	the	the	DET
app-558	138	28	enzyme18	enzyme18	NOUN
app-558	138	29	.	.	PUNCT
app-558	139	1	this	this	DET
app-558	139	2	model	model	NOUN
app-558	139	3	helps	help	VERB
app-558	139	4	explain	explain	VERB
app-558	139	5	the	the	DET
app-558	139	6	effects	effect	NOUN
app-558	139	7	of	of	ADP
app-558	139	8	missense	missense	NOUN
app-558	139	9	mutations	mutation	NOUN
app-558	139	10	associated	associate	VERB
app-558	139	11	with	with	ADP
app-558	139	12	hibm	hibm	PROPN
app-558	139	13	or	or	CCONJ
app-558	139	14	sialuria	sialuria	NOUN
app-558	139	15	on	on	ADP
app-558	139	16	enzyme	enzyme	NOUN
app-558	139	17	actions	action	NOUN
app-558	139	18	,	,	PUNCT
app-558	139	19	helix	helix	ADJ
app-558	139	20	arrangement	arrangement	NOUN
app-558	139	21	,	,	PUNCT
app-558	139	22	and	and	CCONJ
app-558	139	23	substrate	substrate	NOUN
app-558	139	24	binding	bind	VERB
app-558	139	25	.	.	PUNCT
app-558	140	1	they	they	PRON
app-558	140	2	confirmed	confirm	VERB
app-558	140	3	that	that	SCONJ
app-558	140	4	all	all	PRON
app-558	140	5	reported	report	VERB
app-558	140	6	mutations	mutation	NOUN
app-558	140	7	so	so	ADV
app-558	140	8	far	far	ADV
app-558	140	9	are	be	AUX
app-558	140	10	,	,	PUNCT
app-558	140	11	in	in	ADP
app-558	140	12	fact	fact	NOUN
app-558	140	13	,	,	PUNCT
app-558	140	14	due	due	ADP
app-558	140	15	to	to	ADP
app-558	140	16	the	the	DET
app-558	140	17	mutations	mutation	NOUN
app-558	140	18	in	in	ADP
app-558	140	19	the	the	DET
app-558	140	20	active	active	ADJ
app-558	140	21	site	site	NOUN
app-558	140	22	or	or	CCONJ
app-558	140	23	secondary	secondary	ADJ
app-558	140	24	interfaces	interface	NOUN
app-558	140	25	of	of	ADP
app-558	140	26	the	the	DET
app-558	140	27	gne	gne	PROPN
app-558	140	28	/	/	SYM
app-558	140	29	mnk	mnk	PROPN
app-558	140	30	enzyme	enzyme	NOUN
app-558	140	31	.	.	PUNCT
app-558	141	1	it	it	PRON
app-558	141	2	was	be	AUX
app-558	141	3	reported	report	VERB
app-558	141	4	that	that	SCONJ
app-558	141	5	a	a	DET
app-558	141	6	persian	persian	ADJ
app-558	141	7	-	-	PUNCT
app-558	141	8	jewish	jewish	ADJ
app-558	141	9	hibm	hibm	NOUN
app-558	141	10	has	have	VERB
app-558	141	11	mutation	mutation	NOUN
app-558	141	12	p.m12	p.m12	PROPN
app-558	141	13	t	t	NOUN
app-558	141	14	at	at	ADP
app-558	141	15	the	the	DET
app-558	141	16	interface	interface	NOUN
app-558	141	17	of	of	ADP
app-558	141	18	alpha4	alpha4	NOUN
app-558	141	19	alpha10	alpha10	PROPN
app-558	141	20	that	that	PRON
app-558	141	21	affected	affect	VERB
app-558	141	22	glcnac	glcnac	NOUN
app-558	141	23	,	,	PUNCT
app-558	141	24	mg+2	mg+2	X
app-558	141	25	,	,	PUNCT
app-558	141	26	atp	atp	NOUN
app-558	141	27	binding	binding	NOUN
app-558	141	28	.	.	PUNCT
app-558	142	1	structural	structural	ADJ
app-558	142	2	data	datum	NOUN
app-558	142	3	helps	help	VERB
app-558	142	4	develop	develop	VERB
app-558	142	5	the	the	DET
app-558	142	6	therapeutic	therapeutic	ADJ
app-558	142	7	options	option	NOUN
app-558	142	8	that	that	PRON
app-558	142	9	target	target	VERB
app-558	142	10	the	the	DET
app-558	142	11	misfolding	misfolding	NOUN
app-558	142	12	of	of	ADP
app-558	142	13	gne	gne	PROPN
app-558	142	14	/	/	SYM
app-558	142	15	mnk	mnk	PROPN
app-558	142	16	in	in	ADP
app-558	142	17	hibm	hibm	PROPN
app-558	142	18	or	or	CCONJ
app-558	142	19	sialuria18	sialuria18	ADJ
app-558	142	20	.	.	PUNCT
app-558	143	1	in	in	ADP
app-558	143	2	this	this	DET
app-558	143	3	study	study	NOUN
app-558	143	4	,	,	PUNCT
app-558	143	5	a	a	DET
app-558	143	6	few	few	ADJ
app-558	143	7	experiments	experiment	NOUN
app-558	143	8	were	be	AUX
app-558	143	9	carried	carry	VERB
app-558	143	10	out	out	ADP
app-558	143	11	separately	separately	ADV
app-558	143	12	to	to	PART
app-558	143	13	determine	determine	VERB
app-558	143	14	the	the	DET
app-558	143	15	sialic	sialic	ADJ
app-558	143	16	acid	acid	NOUN
app-558	143	17	levels	level	NOUN
app-558	143	18	in	in	ADP
app-558	143	19	urine	urine	NOUN
app-558	143	20	and	and	CCONJ
app-558	143	21	gne	gne	PROPN
app-558	143	22	mrna	mrna	PROPN
app-558	143	23	expression	expression	NOUN
app-558	143	24	levels	level	NOUN
app-558	143	25	in	in	ADP
app-558	143	26	the	the	DET
app-558	143	27	blood	blood	NOUN
app-558	143	28	of	of	ADP
app-558	143	29	different	different	ADJ
app-558	143	30	subtypes	subtype	NOUN
app-558	143	31	of	of	ADP
app-558	143	32	i.d	i.d	PROPN
app-558	143	33	.	.	PROPN
app-558	143	34	subjects	subject	NOUN
app-558	143	35	.	.	PUNCT
app-558	144	1	the	the	DET
app-558	144	2	data	datum	NOUN
app-558	144	3	show	show	VERB
app-558	144	4	a	a	DET
app-558	144	5	significant	significant	ADJ
app-558	144	6	increase	increase	NOUN
app-558	144	7	in	in	ADP
app-558	144	8	urinary	urinary	ADJ
app-558	144	9	sialic	sialic	ADJ
app-558	144	10	acid	acid	NOUN
app-558	144	11	in	in	ADP
app-558	144	12	mild	mild	ADJ
app-558	144	13	i.d	i.d	PROPN
app-558	144	14	.	.	PROPN
app-558	144	15	subjects	subject	NOUN
app-558	144	16	and	and	CCONJ
app-558	144	17	reduced	reduce	VERB
app-558	144	18	gne	gne	PROPN
app-558	144	19	gene	gene	NOUN
app-558	144	20	expression	expression	NOUN
app-558	144	21	in	in	ADP
app-558	144	22	severe	severe	ADJ
app-558	144	23	i.d	i.d	PROPN
app-558	144	24	.	.	PROPN
app-558	144	25	subjects	subject	NOUN
app-558	144	26	.	.	PUNCT
app-558	145	1	it	it	PRON
app-558	145	2	has	have	AUX
app-558	145	3	been	be	AUX
app-558	145	4	reported	report	VERB
app-558	145	5	previously	previously	ADV
app-558	145	6	that	that	SCONJ
app-558	145	7	patients	patient	NOUN
app-558	145	8	with	with	ADP
app-558	145	9	sialuria	sialuria	PROPN
app-558	145	10	tend	tend	VERB
app-558	145	11	to	to	PART
app-558	145	12	excrete	excrete	VERB
app-558	145	13	more	more	ADJ
app-558	145	14	s.a	s.a	PROPN
app-558	145	15	.	.	PROPN
app-558	145	16	in	in	ADP
app-558	145	17	urine	urine	NOUN
app-558	145	18	than	than	ADP
app-558	145	19	controls	control	NOUN
app-558	145	20	.	.	PUNCT
app-558	146	1	it	it	PRON
app-558	146	2	has	have	AUX
app-558	146	3	been	be	AUX
app-558	146	4	shown	show	VERB
app-558	146	5	that	that	SCONJ
app-558	146	6	the	the	DET
app-558	146	7	levels	level	NOUN
app-558	146	8	range	range	VERB
app-558	146	9	from	from	ADP
app-558	146	10	10	10	NUM
app-558	146	11	to	to	PART
app-558	146	12	30	30	NUM
app-558	146	13	folds	fold	NOUN
app-558	146	14	is	be	AUX
app-558	146	15	associated	associate	VERB
app-558	146	16	with	with	ADP
app-558	146	17	several	several	ADJ
app-558	146	18	inborn	inborn	ADJ
app-558	146	19	errors	error	NOUN
app-558	146	20	of	of	ADP
app-558	146	21	metabolic	metabolic	NOUN
app-558	146	22	diseases	disease	NOUN
app-558	146	23	such	such	ADJ
app-558	146	24	as	as	ADP
app-558	146	25	salla	salla	NOUN
app-558	146	26	disease	disease	NOUN
app-558	146	27	,	,	PUNCT
app-558	146	28	sialidosis	sialidosis	ADJ
app-558	146	29	,	,	PUNCT
app-558	146	30	issd	issd	NOUN
app-558	146	31	,	,	PUNCT
app-558	146	32	and	and	CCONJ
app-558	146	33	neuraminidase	neuraminidase	PROPN
app-558	146	34	deficiency5	deficiency5	PROPN
app-558	146	35	,	,	PUNCT
app-558	146	36	6	6	NUM
app-558	146	37	,	,	PUNCT
app-558	146	38	19	19	NUM
app-558	146	39	,	,	PUNCT
app-558	146	40	20	20	NUM
app-558	146	41	.	.	PUNCT
app-558	147	1	in	in	ADP
app-558	147	2	sialuria	sialuria	PROPN
app-558	147	3	,	,	PUNCT
app-558	147	4	free	free	ADJ
app-558	147	5	sialic	sialic	ADJ
app-558	147	6	acid	acid	NOUN
app-558	147	7	levels	level	NOUN
app-558	147	8	can	can	AUX
app-558	147	9	be	be	AUX
app-558	147	10	elevated	elevate	VERB
app-558	147	11	up	up	ADP
app-558	147	12	to	to	ADP
app-558	147	13	70	70	NUM
app-558	147	14	to	to	PART
app-558	147	15	200	200	NUM
app-558	147	16	folds7	folds7	NOUN
app-558	147	17	,	,	PUNCT
app-558	147	18	8	8	NUM
app-558	147	19	,	,	PUNCT
app-558	147	20	21	21	NUM
app-558	147	21	,	,	PUNCT
app-558	147	22	22	22	NUM
app-558	147	23	.	.	PUNCT
app-558	148	1	an	an	DET
app-558	148	2	earlier	early	ADJ
app-558	148	3	study	study	NOUN
app-558	148	4	reported	report	VERB
app-558	148	5	a	a	DET
app-558	148	6	sixth	sixth	ADJ
app-558	148	7	subject	subject	NOUN
app-558	148	8	of	of	ADP
app-558	148	9	sialuria	sialuria	PRON
app-558	148	10	with	with	ADP
app-558	148	11	mild	mild	ADJ
app-558	148	12	developmental	developmental	ADJ
app-558	148	13	impairment	impairment	NOUN
app-558	148	14	showing	show	VERB
app-558	148	15	an	an	DET
app-558	148	16	increased	increased	ADJ
app-558	148	17	level	level	NOUN
app-558	148	18	of	of	ADP
app-558	148	19	sialic	sialic	ADJ
app-558	148	20	acid	acid	NOUN
app-558	148	21	in	in	ADP
app-558	148	22	his	his	PRON
app-558	148	23	urine	urine	NOUN
app-558	148	24	.	.	PUNCT
app-558	149	1	this	this	PRON
app-558	149	2	is	be	AUX
app-558	149	3	consistent	consistent	ADJ
app-558	149	4	with	with	ADP
app-558	149	5	the	the	DET
app-558	149	6	current	current	ADJ
app-558	149	7	study	study	NOUN
app-558	149	8	that	that	PRON
app-558	149	9	showed	show	VERB
app-558	149	10	an	an	DET
app-558	149	11	increased	increase	VERB
app-558	149	12	sialic	sialic	ADJ
app-558	149	13	acid	acid	NOUN
app-558	149	14	level	level	NOUN
app-558	149	15	in	in	ADP
app-558	149	16	the	the	DET
app-558	149	17	urine	urine	NOUN
app-558	149	18	.	.	PUNCT
app-558	150	1	subjects	subject	NOUN
app-558	150	2	with	with	ADP
app-558	150	3	mild	mild	ADJ
app-558	150	4	intellectual	intellectual	ADJ
app-558	150	5	disability	disability	NOUN
app-558	150	6	exhibiting	exhibit	VERB
app-558	150	7	a	a	DET
app-558	150	8	2fold	2fold	NUM
app-558	150	9	increase	increase	NOUN
app-558	150	10	in	in	ADP
app-558	150	11	free	free	ADJ
app-558	150	12	sialic	sialic	ADJ
app-558	150	13	acid	acid	NOUN
app-558	150	14	levels	level	NOUN
app-558	150	15	than	than	ADP
app-558	150	16	controls	control	NOUN
app-558	150	17	proved	prove	VERB
app-558	150	18	that	that	SCONJ
app-558	150	19	mild	mild	ADJ
app-558	150	20	phenotype	phenotype	NOUN
app-558	150	21	of	of	ADP
app-558	150	22	intellectual	intellectual	ADJ
app-558	150	23	disability	disability	NOUN
app-558	150	24	might	might	AUX
app-558	150	25	be	be	AUX
app-558	150	26	associated	associate	VERB
app-558	150	27	with	with	ADP
app-558	150	28	sialuria	sialuria	PROPN
app-558	150	29	.	.	PUNCT
app-558	151	1	moreover	moreover	ADV
app-558	151	2	,	,	PUNCT
app-558	151	3	data	datum	NOUN
app-558	151	4	on	on	ADP
app-558	151	5	the	the	DET
app-558	151	6	singlefamily	singlefamily	NOUN
app-558	151	7	also	also	ADV
app-558	151	8	showed	show	VERB
app-558	151	9	about	about	ADV
app-558	151	10	10	10	NUM
app-558	151	11	-	-	ADJ
app-558	151	12	fold	fold	ADJ
app-558	151	13	increased	increase	VERB
app-558	151	14	sialic	sialic	ADJ
app-558	151	15	acid	acid	NOUN
app-558	151	16	levels	level	NOUN
app-558	151	17	in	in	ADP
app-558	151	18	urine	urine	NOUN
app-558	151	19	;	;	PUNCT
app-558	151	20	however	however	ADV
app-558	151	21	,	,	PUNCT
app-558	151	22	the	the	DET
app-558	151	23	reductions	reduction	NOUN
app-558	151	24	in	in	ADP
app-558	151	25	free	free	ADJ
app-558	151	26	sialic	sialic	ADJ
app-558	151	27	acid	acid	NOUN
app-558	151	28	levels	level	NOUN
app-558	151	29	in	in	ADP
app-558	151	30	subjects	subject	NOUN
app-558	151	31	with	with	ADP
app-558	151	32	severe	severe	ADJ
app-558	151	33	intellectual	intellectual	ADJ
app-558	151	34	disability	disability	NOUN
app-558	151	35	showed	show	VERB
app-558	151	36	that	that	SCONJ
app-558	151	37	severe	severe	ADJ
app-558	151	38	i.d	i.d	PROPN
app-558	151	39	.	.	PROPN
app-558	151	40	might	might	AUX
app-558	151	41	not	not	PART
app-558	151	42	be	be	AUX
app-558	151	43	linked	link	VERB
app-558	151	44	with	with	ADP
app-558	151	45	sialuria	sialuria	PROPN
app-558	151	46	disease	disease	NOUN
app-558	151	47	in	in	ADP
app-558	151	48	pakistani	pakistani	ADJ
app-558	151	49	children	child	NOUN
app-558	151	50	and	and	CCONJ
app-558	151	51	adolescents	adolescent	NOUN
app-558	151	52	.	.	PUNCT
app-558	152	1	for	for	ADP
app-558	152	2	confirmation	confirmation	NOUN
app-558	152	3	,	,	PUNCT
app-558	152	4	we	we	PRON
app-558	152	5	analyzed	analyze	VERB
app-558	152	6	and	and	CCONJ
app-558	152	7	compared	compare	VERB
app-558	152	8	the	the	DET
app-558	152	9	expression	expression	NOUN
app-558	152	10	pattern	pattern	NOUN
app-558	152	11	of	of	ADP
app-558	152	12	the	the	DET
app-558	152	13	gne	gne	PROPN
app-558	152	14	gene	gene	NOUN
app-558	152	15	in	in	ADP
app-558	152	16	controls	control	NOUN
app-558	152	17	and	and	CCONJ
app-558	152	18	severe	severe	ADJ
app-558	152	19	i	i	PROPN
app-558	152	20	d	d	PROPN
app-558	152	21	children	child	NOUN
app-558	152	22	and	and	CCONJ
app-558	152	23	adolescents	adolescent	NOUN
app-558	152	24	of	of	ADP
app-558	152	25	pakistan	pakistan	PROPN
app-558	152	26	.	.	PUNCT
app-558	153	1	all	all	DET
app-558	153	2	subjects	subject	NOUN
app-558	153	3	with	with	ADP
app-558	153	4	severe	severe	ADJ
app-558	153	5	i	i	PROPN
app-558	153	6	d	d	PROPN
app-558	153	7	showed	show	VERB
app-558	153	8	down	down	ADP
app-558	153	9	-	-	PUNCT
app-558	153	10	regulation	regulation	NOUN
app-558	153	11	when	when	SCONJ
app-558	153	12	92	92	NUM
app-558	153	13	issn	issn	PROPN
app-558	153	14	2412	2412	NUM
app-558	153	15	-	-	SYM
app-558	153	16	3188	3188	NUM
app-558	153	17	(	(	PUNCT
app-558	153	18	online	online	NOUN
app-558	153	19	)	)	PUNCT
app-558	153	20	|	|	ADV
app-558	153	21	2410	2410	NUM
app-558	153	22	-	-	SYM
app-558	153	23	1354	1354	NUM
app-558	153	24	(	(	PUNCT
app-558	153	25	print	print	NOUN
app-558	153	26	)	)	PUNCT
app-558	153	27	app|	app|	NOUN
app-558	153	28	published	publish	VERB
app-558	153	29	by	by	ADP
app-558	153	30	aeirc|	aeirc|	ADP
app-558	153	31	volume	volume	NOUN
app-558	153	32	8	8	NUM
app-558	153	33	issue	issue	NOUN
app-558	153	34	2	2	NUM
app-558	153	35	compared	compare	VERB
app-558	153	36	to	to	ADP
app-558	153	37	controls	control	NOUN
app-558	153	38	.	.	PUNCT
app-558	154	1	in	in	ADP
app-558	154	2	earlier	early	ADJ
app-558	154	3	studies	study	NOUN
app-558	154	4	,	,	PUNCT
app-558	154	5	subjects	subject	NOUN
app-558	154	6	with	with	ADP
app-558	154	7	mild	mild	ADJ
app-558	154	8	impairments	impairment	NOUN
app-558	154	9	showed	show	VERB
app-558	154	10	high	high	ADJ
app-558	154	11	expression	expression	NOUN
app-558	154	12	of	of	ADP
app-558	154	13	the	the	DET
app-558	154	14	gne	gne	PROPN
app-558	154	15	gene	gene	NOUN
app-558	154	16	in	in	ADP
app-558	154	17	their	their	PRON
app-558	154	18	different	different	ADJ
app-558	154	19	tissue	tissue	NOUN
app-558	154	20	organs10	organs10	NOUN
app-558	154	21	.	.	PUNCT
app-558	155	1	in	in	ADP
app-558	155	2	contrast	contrast	NOUN
app-558	155	3	,	,	PUNCT
app-558	155	4	when	when	SCONJ
app-558	155	5	we	we	PRON
app-558	155	6	analyzed	analyze	VERB
app-558	155	7	the	the	DET
app-558	155	8	expression	expression	NOUN
app-558	155	9	levels	level	NOUN
app-558	155	10	of	of	ADP
app-558	155	11	gne	gne	PROPN
app-558	155	12	in	in	ADP
app-558	155	13	subjects	subject	NOUN
app-558	155	14	with	with	ADP
app-558	155	15	severe	severe	ADJ
app-558	155	16	i.d	i.d	PROPN
app-558	155	17	.	.	PROPN
app-558	155	18	who	who	PRON
app-558	155	19	were	be	AUX
app-558	155	20	suffering	suffer	VERB
app-558	155	21	from	from	ADP
app-558	155	22	severe	severe	ADJ
app-558	155	23	developmental	developmental	ADJ
app-558	155	24	delay	delay	NOUN
app-558	155	25	,	,	PUNCT
app-558	155	26	our	our	PRON
app-558	155	27	results	result	NOUN
app-558	155	28	show	show	VERB
app-558	155	29	significantly	significantly	ADV
app-558	155	30	low	low	ADJ
app-558	155	31	expression	expression	NOUN
app-558	155	32	levels	level	NOUN
app-558	155	33	in	in	ADP
app-558	155	34	these	these	DET
app-558	155	35	subjects	subject	NOUN
app-558	155	36	,	,	PUNCT
app-558	155	37	suggesting	suggest	VERB
app-558	155	38	no	no	DET
app-558	155	39	association	association	NOUN
app-558	155	40	of	of	ADP
app-558	155	41	sialuria	sialuria	PROPN
app-558	155	42	with	with	ADP
app-558	155	43	severe	severe	ADJ
app-558	155	44	mental	mental	ADJ
app-558	155	45	illnesses	illness	NOUN
app-558	155	46	.	.	PUNCT
app-558	156	1	nevertheless	nevertheless	ADV
app-558	156	2	,	,	PUNCT
app-558	156	3	only	only	ADV
app-558	156	4	gne	gne	PROPN
app-558	156	5	mrna	mrna	PROPN
app-558	156	6	and	and	CCONJ
app-558	156	7	urinary	urinary	ADJ
app-558	156	8	sialic	sialic	ADJ
app-558	156	9	acid	acid	NOUN
app-558	156	10	levels	level	NOUN
app-558	156	11	from	from	ADP
app-558	156	12	severe	severe	ADJ
app-558	156	13	i.d	i.d	PROPN
app-558	156	14	.	.	PROPN
app-558	156	15	patients	patient	NOUN
app-558	156	16	have	have	AUX
app-558	156	17	shown	show	VERB
app-558	156	18	a	a	DET
app-558	156	19	significant	significant	ADJ
app-558	156	20	correlation	correlation	NOUN
app-558	156	21	.	.	PUNCT
app-558	157	1	this	this	PRON
app-558	157	2	means	mean	VERB
app-558	157	3	an	an	DET
app-558	157	4	increased	increase	VERB
app-558	157	5	gne	gne	PROPN
app-558	157	6	mrna	mrna	PROPN
app-558	157	7	expression	expression	NOUN
app-558	157	8	levels	level	NOUN
app-558	157	9	positively	positively	ADV
app-558	157	10	influence	influence	VERB
app-558	157	11	the	the	DET
app-558	157	12	low	low	ADJ
app-558	157	13	excretion	excretion	NOUN
app-558	157	14	of	of	ADP
app-558	157	15	sialic	sialic	ADJ
app-558	157	16	acid	acid	NOUN
app-558	157	17	levels	level	NOUN
app-558	157	18	in	in	ADP
app-558	157	19	urine	urine	NOUN
app-558	157	20	.	.	PUNCT
app-558	158	1	as	as	SCONJ
app-558	158	2	silauria	silauria	PROPN
app-558	158	3	is	be	AUX
app-558	158	4	known	know	VERB
app-558	158	5	to	to	PART
app-558	158	6	cause	cause	VERB
app-558	158	7	an	an	DET
app-558	158	8	accumulation	accumulation	NOUN
app-558	158	9	and	and	CCONJ
app-558	158	10	urinary	urinary	ADJ
app-558	158	11	excretion	excretion	NOUN
app-558	158	12	of	of	ADP
app-558	158	13	neu5ac	neu5ac	PROPN
app-558	158	14	sialuria	sialuria	PROPN
app-558	158	15	,	,	PUNCT
app-558	158	16	it	it	PRON
app-558	158	17	differs	differ	VERB
app-558	158	18	from	from	ADP
app-558	158	19	sialdoses	sialdose	NOUN
app-558	158	20	,	,	PUNCT
app-558	158	21	characterized	characterize	VERB
app-558	158	22	as	as	ADP
app-558	158	23	a	a	DET
app-558	158	24	defect	defect	NOUN
app-558	158	25	in	in	ADP
app-558	158	26	the	the	DET
app-558	158	27	storage	storage	NOUN
app-558	158	28	and	and	CCONJ
app-558	158	29	excretion	excretion	NOUN
app-558	158	30	of	of	ADP
app-558	158	31	bound	bind	VERB
app-558	158	32	neu5ac	neu5ac	PROPN
app-558	158	33	from	from	ADP
app-558	158	34	the	the	DET
app-558	158	35	body	body	NOUN
app-558	158	36	.	.	PUNCT
app-558	159	1	the	the	DET
app-558	159	2	same	same	ADJ
app-558	159	3	gne	gne	PROPN
app-558	159	4	gene	gene	NOUN
app-558	159	5	is	be	AUX
app-558	159	6	involved	involve	VERB
app-558	159	7	in	in	ADP
app-558	159	8	causing	cause	VERB
app-558	159	9	nonaka	nonaka	PROPN
app-558	159	10	myopathy	myopathy	ADJ
app-558	159	11	(	(	PUNCT
app-558	159	12	nk	nk	PROPN
app-558	159	13	;	;	PUNCT
app-558	159	14	mim:605820	mim:605820	NOUN
app-558	159	15	)	)	PUNCT
app-558	159	16	as	as	ADV
app-558	159	17	well	well	ADV
app-558	159	18	,	,	PUNCT
app-558	159	19	besides	besides	SCONJ
app-558	159	20	sialuria	sialuria	PROPN
app-558	159	21	and	and	CCONJ
app-558	159	22	sialdoses	sialdose	NOUN
app-558	159	23	.	.	PUNCT
app-558	160	1	in	in	ADP
app-558	160	2	nonaka	nonaka	PROPN
app-558	160	3	myopathy	myopathy	ADJ
app-558	160	4	,	,	PUNCT
app-558	160	5	muscle	muscle	NOUN
app-558	160	6	wasting	wasting	NOUN
app-558	160	7	and	and	CCONJ
app-558	160	8	weakness	weakness	NOUN
app-558	160	9	of	of	ADP
app-558	160	10	the	the	DET
app-558	160	11	distal	distal	ADJ
app-558	160	12	and	and	CCONJ
app-558	160	13	anterior	anterior	ADJ
app-558	160	14	tibial	tibial	ADJ
app-558	160	15	muscles	muscle	NOUN
app-558	160	16	takes	take	VERB
app-558	160	17	place23,24	place23,24	NOUN
app-558	160	18	.	.	PUNCT
app-558	161	1	several	several	ADJ
app-558	161	2	mutations	mutation	NOUN
app-558	161	3	in	in	ADP
app-558	161	4	the	the	DET
app-558	161	5	gne	gne	PROPN
app-558	161	6	gene	gene	NOUN
app-558	161	7	in	in	ADP
app-558	161	8	epimerase	epimerase	PROPN
app-558	161	9	and	and	CCONJ
app-558	161	10	kinases	kinase	NOUN
app-558	161	11	domains	domain	NOUN
app-558	161	12	alter	alter	VERB
app-558	161	13	the	the	DET
app-558	161	14	enzymatic	enzymatic	ADJ
app-558	161	15	activity	activity	NOUN
app-558	161	16	in	in	ADP
app-558	161	17	a	a	DET
app-558	161	18	very	very	ADV
app-558	161	19	minute	minute	NOUN
app-558	161	20	and	and	CCONJ
app-558	161	21	precise	precise	ADJ
app-558	161	22	way	way	NOUN
app-558	161	23	.	.	PUNCT
app-558	162	1	it	it	PRON
app-558	162	2	is	be	AUX
app-558	162	3	very	very	ADV
app-558	162	4	difficult	difficult	ADJ
app-558	162	5	to	to	PART
app-558	162	6	describe	describe	VERB
app-558	162	7	and	and	CCONJ
app-558	162	8	identify	identify	VERB
app-558	162	9	the	the	DET
app-558	162	10	actual	actual	ADJ
app-558	162	11	effect	effect	NOUN
app-558	162	12	.	.	PUNCT
app-558	163	1	consequently	consequently	ADV
app-558	163	2	,	,	PUNCT
app-558	163	3	sometimes	sometimes	ADV
app-558	163	4	,	,	PUNCT
app-558	163	5	the	the	DET
app-558	163	6	activity	activity	NOUN
app-558	163	7	of	of	ADP
app-558	163	8	the	the	DET
app-558	163	9	enzyme	enzyme	NOUN
app-558	163	10	did	do	AUX
app-558	163	11	not	not	PART
app-558	163	12	correlate	correlate	VERB
app-558	163	13	with	with	ADP
app-558	163	14	the	the	DET
app-558	163	15	severity	severity	NOUN
app-558	163	16	of	of	ADP
app-558	163	17	the	the	DET
app-558	163	18	disease	disease	NOUN
app-558	163	19	25	25	NUM
app-558	163	20	-	-	SYM
app-558	163	21	29	29	NUM
app-558	163	22	.	.	PUNCT
app-558	164	1	the	the	DET
app-558	164	2	predominant	predominant	ADJ
app-558	164	3	function	function	NOUN
app-558	164	4	of	of	ADP
app-558	164	5	gne	gne	PROPN
app-558	164	6	is	be	AUX
app-558	164	7	to	to	PART
app-558	164	8	regulate	regulate	VERB
app-558	164	9	the	the	DET
app-558	164	10	sialylation	sialylation	NOUN
app-558	164	11	of	of	ADP
app-558	164	12	cell	cell	NOUN
app-558	164	13	surface	surface	NOUN
app-558	164	14	glycoproteins	glycoprotein	NOUN
app-558	164	15	and	and	CCONJ
app-558	164	16	glycolipids12	glycolipids12	NOUN
app-558	164	17	-	-	PUNCT
app-558	164	18	15	15	NUM
app-558	164	19	.	.	PUNCT
app-558	165	1	however	however	ADV
app-558	165	2	,	,	PUNCT
app-558	165	3	the	the	DET
app-558	165	4	correlation	correlation	NOUN
app-558	165	5	between	between	ADP
app-558	165	6	hyposialylation	hyposialylation	NOUN
app-558	165	7	and	and	CCONJ
app-558	165	8	the	the	DET
app-558	165	9	severity	severity	NOUN
app-558	165	10	of	of	ADP
app-558	165	11	the	the	DET
app-558	165	12	disease	disease	NOUN
app-558	165	13	is	be	AUX
app-558	165	14	inadequate	inadequate	ADJ
app-558	165	15	because	because	SCONJ
app-558	165	16	many	many	ADJ
app-558	165	17	human	human	ADJ
app-558	165	18	patients	patient	NOUN
app-558	165	19	suffering	suffer	VERB
app-558	165	20	from	from	ADP
app-558	165	21	gne	gne	PROPN
app-558	165	22	myopathy	myopathy	NOUN
app-558	165	23	have	have	VERB
app-558	165	24	sialic	sialic	ADJ
app-558	165	25	acid	acid	NOUN
app-558	165	26	levels	level	NOUN
app-558	165	27	not	not	PART
app-558	165	28	much	much	ADV
app-558	165	29	different	different	ADJ
app-558	165	30	from	from	ADP
app-558	165	31	the	the	DET
app-558	165	32	controls	control	NOUN
app-558	165	33	.	.	PUNCT
app-558	166	1	this	this	PRON
app-558	166	2	is	be	AUX
app-558	166	3	the	the	DET
app-558	166	4	main	main	ADJ
app-558	166	5	reason	reason	NOUN
app-558	166	6	why	why	SCONJ
app-558	166	7	a	a	DET
app-558	166	8	poor	poor	ADJ
app-558	166	9	correlation	correlation	NOUN
app-558	166	10	exists	exist	VERB
app-558	166	11	between	between	ADP
app-558	166	12	sialic	sialic	ADJ
app-558	166	13	acid	acid	NOUN
app-558	166	14	levels	level	NOUN
app-558	166	15	and	and	CCONJ
app-558	166	16	symptom	symptom	NOUN
app-558	166	17	severity	severity	NOUN
app-558	166	18	.	.	PUNCT
app-558	167	1	these	these	DET
app-558	167	2	results	result	NOUN
app-558	167	3	were	be	AUX
app-558	167	4	also	also	ADV
app-558	167	5	seen	see	VERB
app-558	167	6	in	in	ADP
app-558	167	7	animal	animal	NOUN
app-558	167	8	models	model	NOUN
app-558	167	9	with	with	ADP
app-558	167	10	d176v	d176v	PROPN
app-558	167	11	mutation	mutation	NOUN
app-558	167	12	in	in	ADP
app-558	167	13	gne	gne	PROPN
app-558	167	14	gene	gene	NOUN
app-558	167	15	30	30	NUM
app-558	167	16	.	.	PUNCT
app-558	168	1	the	the	DET
app-558	168	2	symptoms	symptom	NOUN
app-558	168	3	in	in	ADP
app-558	168	4	patients	patient	NOUN
app-558	168	5	and	and	CCONJ
app-558	168	6	mutant	mutant	ADJ
app-558	168	7	mice	mouse	NOUN
app-558	168	8	show	show	VERB
app-558	168	9	normal	normal	ADJ
app-558	168	10	and	and	CCONJ
app-558	168	11	early	early	ADJ
app-558	168	12	birth	birth	NOUN
app-558	168	13	but	but	CCONJ
app-558	168	14	develop	develop	VERB
app-558	168	15	muscle	muscle	NOUN
app-558	168	16	weakness	weakness	NOUN
app-558	168	17	as	as	SCONJ
app-558	168	18	they	they	PRON
app-558	168	19	age	age	VERB
app-558	168	20	,	,	PUNCT
app-558	168	21	which	which	PRON
app-558	168	22	can	can	AUX
app-558	168	23	be	be	AUX
app-558	168	24	relieved	relieve	VERB
app-558	168	25	by	by	ADP
app-558	168	26	providing	provide	VERB
app-558	168	27	them	they	PRON
app-558	168	28	sialic	sialic	ADJ
app-558	168	29	acid	acid	NOUN
app-558	168	30	or	or	CCONJ
app-558	168	31	mannac	mannac	NOUN
app-558	168	32	.	.	PUNCT
app-558	169	1	nevertheless	nevertheless	ADV
app-558	169	2	,	,	PUNCT
app-558	169	3	the	the	DET
app-558	169	4	sialic	sialic	ADJ
app-558	169	5	acid	acid	NOUN
app-558	169	6	levels	level	NOUN
app-558	169	7	in	in	ADP
app-558	169	8	animals	animal	NOUN
app-558	169	9	remained	remain	VERB
app-558	169	10	low	low	ADJ
app-558	169	11	than	than	ADP
app-558	169	12	in	in	ADP
app-558	169	13	control	control	NOUN
app-558	169	14	animals31	animals31	PROPN
app-558	169	15	.	.	PUNCT
app-558	170	1	they	they	PRON
app-558	170	2	suggested	suggest	VERB
app-558	170	3	a	a	DET
app-558	170	4	lack	lack	NOUN
app-558	170	5	of	of	ADP
app-558	170	6	correlation	correlation	NOUN
app-558	170	7	between	between	ADP
app-558	170	8	the	the	DET
app-558	170	9	severity	severity	NOUN
app-558	170	10	of	of	ADP
app-558	170	11	the	the	DET
app-558	170	12	disease	disease	NOUN
app-558	170	13	and	and	CCONJ
app-558	170	14	the	the	DET
app-558	170	15	sialic	sialic	ADJ
app-558	170	16	acid	acid	PROPN
app-558	170	17	levels	level	NOUN
app-558	170	18	,	,	PUNCT
app-558	170	19	emphasizing	emphasize	VERB
app-558	170	20	that	that	SCONJ
app-558	170	21	gne	gne	PROPN
app-558	170	22	gene	gene	NOUN
app-558	170	23	mutation	mutation	NOUN
app-558	170	24	has	have	VERB
app-558	170	25	effects	effect	NOUN
app-558	170	26	beyond	beyond	ADP
app-558	170	27	hyposialylation	hyposialylation	NOUN
app-558	170	28	.	.	PUNCT
app-558	171	1	the	the	DET
app-558	171	2	mutation	mutation	NOUN
app-558	171	3	can	can	AUX
app-558	171	4	affect	affect	VERB
app-558	171	5	the	the	DET
app-558	171	6	n	n	CCONJ
app-558	171	7	-	-	PUNCT
app-558	171	8	glycan	glycan	NOUN
app-558	171	9	structure	structure	NOUN
app-558	171	10	by	by	ADP
app-558	171	11	changing	change	VERB
app-558	171	12	the	the	DET
app-558	171	13	sialic	sialic	ADJ
app-558	171	14	acid	acid	NOUN
app-558	171	15	biosynthesis	biosynthesis	NOUN
app-558	171	16	and	and	CCONJ
app-558	171	17	flux	flux	PROPN
app-558	171	18	udp	udp	PROPN
app-558	171	19	-	-	ADJ
app-558	171	20	glcnac	glcnac	ADJ
app-558	171	21	levels	level	NOUN
app-558	171	22	via	via	ADP
app-558	171	23	hexosamine	hexosamine	ADJ
app-558	171	24	biosynthetic	biosynthetic	PROPN
app-558	171	25	pathway32,33	pathway32,33	PROPN
app-558	171	26	.	.	PUNCT
app-558	172	1	our	our	PRON
app-558	172	2	results	result	NOUN
app-558	172	3	propose	propose	VERB
app-558	172	4	that	that	SCONJ
app-558	172	5	early	early	ADJ
app-558	172	6	effective	effective	ADJ
app-558	172	7	avoidance	avoidance	NOUN
app-558	172	8	from	from	ADP
app-558	172	9	severe	severe	ADJ
app-558	172	10	cognitive	cognitive	ADJ
app-558	172	11	disabilities	disability	NOUN
app-558	172	12	will	will	AUX
app-558	172	13	obtain	obtain	VERB
app-558	172	14	better	well	ADJ
app-558	172	15	information	information	NOUN
app-558	172	16	and	and	CCONJ
app-558	172	17	averting	avert	VERB
app-558	172	18	the	the	DET
app-558	172	19	risk	risk	NOUN
app-558	172	20	factors	factor	NOUN
app-558	172	21	such	such	ADJ
app-558	172	22	as	as	ADP
app-558	172	23	low	low	ADJ
app-558	172	24	birth	birth	NOUN
app-558	172	25	weight	weight	NOUN
app-558	172	26	,	,	PUNCT
app-558	172	27	hypoxia	hypoxia	NOUN
app-558	172	28	,	,	PUNCT
app-558	172	29	poverty	poverty	NOUN
app-558	172	30	,	,	PUNCT
app-558	172	31	and	and	CCONJ
app-558	172	32	serious	serious	ADJ
app-558	172	33	diseases	disease	NOUN
app-558	172	34	.	.	PUNCT
app-558	173	1	conclusion	conclusion	VERB
app-558	173	2	the	the	DET
app-558	173	3	urine	urine	NOUN
app-558	173	4	analysis	analysis	NOUN
app-558	173	5	of	of	ADP
app-558	173	6	sialic	sialic	ADJ
app-558	173	7	acid	acid	PROPN
app-558	173	8	showed	show	VERB
app-558	173	9	a	a	DET
app-558	173	10	significant	significant	ADJ
app-558	173	11	reduction	reduction	NOUN
app-558	173	12	in	in	ADP
app-558	173	13	severe	severe	ADJ
app-558	173	14	mental	mental	ADJ
app-558	173	15	retarded	retarded	ADJ
app-558	173	16	samples	sample	NOUN
app-558	173	17	.	.	PUNCT
app-558	174	1	there	there	PRON
app-558	174	2	was	be	VERB
app-558	174	3	an	an	DET
app-558	174	4	ave	ave	NOUN
app-558	174	5	rage	rage	NOUN
app-558	174	6	two	two	NUM
app-558	174	7	-	-	PUNCT
app-558	174	8	fold	fold	ADJ
app-558	174	9	increase	increase	NOUN
app-558	174	10	in	in	ADP
app-558	174	11	the	the	DET
app-558	174	12	urinary	urinary	ADJ
app-558	174	13	sialic	sialic	ADJ
app-558	174	14	acid	acid	NOUN
app-558	174	15	levels	level	NOUN
app-558	174	16	in	in	ADP
app-558	174	17	mild	mild	ADJ
app-558	174	18	i.d	i.d	PROPN
app-558	174	19	.	.	PROPN
app-558	174	20	subjects	subject	NOUN
app-558	174	21	compared	compare	VERB
app-558	174	22	to	to	ADP
app-558	174	23	controls	control	NOUN
app-558	174	24	.	.	PUNCT
app-558	175	1	results	result	NOUN
app-558	175	2	from	from	ADP
app-558	175	3	rt	rt	NOUN
app-558	175	4	-	-	PUNCT
app-558	175	5	qpcr	qpcr	ADV
app-558	175	6	showed	show	VERB
app-558	175	7	a	a	DET
app-558	175	8	significant	significant	ADJ
app-558	175	9	reduction	reduction	NOUN
app-558	175	10	in	in	ADP
app-558	175	11	the	the	DET
app-558	175	12	i.d	i.d	PROPN
app-558	175	13	.	.	PROPN
app-558	175	14	mrna	mrna	PROPN
app-558	175	15	expression	expression	NOUN
app-558	175	16	of	of	ADP
app-558	175	17	the	the	DET
app-558	175	18	gne	gne	PROPN
app-558	175	19	gene	gene	NOUN
app-558	175	20	in	in	ADP
app-558	175	21	mild	mild	ADJ
app-558	175	22	,	,	PUNCT
app-558	175	23	moderate	moderate	ADJ
app-558	175	24	,	,	PUNCT
app-558	175	25	and	and	CCONJ
app-558	175	26	severe	severe	ADJ
app-558	175	27	i.d	i.d	PROPN
app-558	175	28	.	.	PROPN
app-558	175	29	subjects	subject	NOUN
app-558	175	30	.	.	PUNCT
app-558	176	1	there	there	PRON
app-558	176	2	was	be	VERB
app-558	176	3	a	a	DET
app-558	176	4	fivefold	fivefold	ADJ
app-558	176	5	up	up	NOUN
app-558	176	6	-	-	PUNCT
app-558	176	7	regulation	regulation	NOUN
app-558	176	8	of	of	ADP
app-558	176	9	gne	gne	PROPN
app-558	176	10	gene	gene	NOUN
app-558	176	11	expression	expression	NOUN
app-558	176	12	in	in	ADP
app-558	176	13	mild	mild	ADJ
app-558	176	14	i.d	i.d	PROPN
app-558	176	15	.	.	PROPN
app-558	176	16	subjects	subject	NOUN
app-558	176	17	compared	compare	VERB
app-558	176	18	to	to	ADP
app-558	176	19	severe	severe	ADJ
app-558	176	20	i.d	i.d	PROPN
app-558	176	21	.	.	PROPN
app-558	176	22	subjects	subject	NOUN
app-558	176	23	.	.	PUNCT
app-558	177	1	only	only	ADV
app-558	177	2	gne	gne	PROPN
app-558	177	3	mrna	mrna	PROPN
app-558	177	4	and	and	CCONJ
app-558	177	5	urinary	urinary	ADJ
app-558	177	6	sialic	sialic	ADJ
app-558	177	7	acid	acid	NOUN
app-558	177	8	levels	level	NOUN
app-558	177	9	from	from	ADP
app-558	177	10	severe	severe	ADJ
app-558	177	11	i.d	i.d	PROPN
app-558	177	12	.	.	PROPN
app-558	177	13	patients	patient	NOUN
app-558	177	14	showed	show	VERB
app-558	177	15	a	a	DET
app-558	177	16	significant	significant	ADJ
app-558	177	17	correlation	correlation	NOUN
app-558	177	18	.	.	PUNCT
app-558	178	1	thus	thus	ADV
app-558	178	2	data	datum	NOUN
app-558	178	3	suggest	suggest	VERB
app-558	178	4	that	that	SCONJ
app-558	178	5	mild	mild	ADJ
app-558	178	6	i.d	i.d	PROPN
app-558	178	7	.	.	PROPN
app-558	178	8	might	might	AUX
app-558	178	9	be	be	AUX
app-558	178	10	associated	associate	VERB
app-558	178	11	with	with	ADP
app-558	178	12	sialuria	sialuria	PROPN
app-558	178	13	in	in	ADP
app-558	178	14	pakistani	pakistani	ADJ
app-558	178	15	children	child	NOUN
app-558	178	16	and	and	CCONJ
app-558	178	17	adolescents	adolescent	NOUN
app-558	178	18	.	.	PUNCT
app-558	179	1	therefore	therefore	ADV
app-558	179	2	,	,	PUNCT
app-558	179	3	intellectually	intellectually	ADV
app-558	179	4	disabled	disabled	ADJ
app-558	179	5	subjects	subject	NOUN
app-558	179	6	and	and	CCONJ
app-558	179	7	their	their	PRON
app-558	179	8	immediate	immediate	ADJ
app-558	179	9	family	family	NOUN
app-558	179	10	members	member	NOUN
app-558	179	11	must	must	AUX
app-558	179	12	be	be	AUX
app-558	179	13	monitored	monitor	VERB
app-558	179	14	for	for	ADP
app-558	179	15	the	the	DET
app-558	179	16	polymorphisms	polymorphism	NOUN
app-558	179	17	in	in	ADP
app-558	179	18	codons	codon	NOUN
app-558	179	19	263	263	NUM
app-558	179	20	to	to	ADP
app-558	179	21	266	266	NUM
app-558	179	22	of	of	ADP
app-558	179	23	the	the	DET
app-558	179	24	gne	gne	PROPN
app-558	179	25	gene	gene	NOUN
app-558	179	26	.	.	PUNCT
app-558	180	1	93	93	NUM
app-558	180	2	issn	issn	PROPN
app-558	180	3	2412	2412	NUM
app-558	180	4	-	-	SYM
app-558	180	5	3188	3188	NUM
app-558	180	6	(	(	PUNCT
app-558	180	7	online	online	NOUN
app-558	180	8	)	)	PUNCT
app-558	180	9	|	|	ADV
app-558	180	10	2410	2410	NUM
app-558	180	11	-	-	SYM
app-558	180	12	1354	1354	NUM
app-558	180	13	(	(	PUNCT
app-558	180	14	print	print	NOUN
app-558	180	15	)	)	PUNCT
app-558	180	16	app|	app|	NOUN
app-558	180	17	published	publish	VERB
app-558	180	18	by	by	ADP
app-558	180	19	aeirc|	aeirc|	ADP
app-558	180	20	volume	volume	NOUN
app-558	180	21	8	8	NUM
app-558	180	22	issue	issue	NOUN
app-558	180	23	2	2	NUM
app-558	180	24	acknowledgment	acknowledgment	NOUN
app-558	180	25	the	the	DET
app-558	180	26	authors	author	NOUN
app-558	180	27	would	would	AUX
app-558	180	28	like	like	VERB
app-558	180	29	to	to	PART
app-558	180	30	thank	thank	VERB
app-558	180	31	dr	dr	PROPN
app-558	180	32	.	.	PROPN
app-558	180	33	deepak	deepak	PROPN
app-558	180	34	kumar	kumar	PROPN
app-558	180	35	for	for	ADP
app-558	180	36	helping	help	VERB
app-558	180	37	in	in	ADP
app-558	180	38	getting	get	VERB
app-558	180	39	the	the	DET
app-558	180	40	ethics	ethic	NOUN
app-558	180	41	approval	approval	NOUN
app-558	180	42	,	,	PUNCT
app-558	180	43	dr	dr	PROPN
app-558	180	44	.	.	PROPN
app-558	180	45	atif	atif	PROPN
app-558	180	46	anjum	anjum	PROPN
app-558	180	47	from	from	ADP
app-558	180	48	national	national	PROPN
app-558	180	49	institute	institute	PROPN
app-558	180	50	of	of	ADP
app-558	180	51	child	child	PROPN
app-558	180	52	health	health	PROPN
app-558	180	53	,	,	PUNCT
app-558	180	54	jinnah	jinnah	PROPN
app-558	180	55	postgraduate	postgraduate	VERB
app-558	180	56	medical	medical	ADJ
app-558	180	57	center	center	NOUN
app-558	180	58	,	,	PUNCT
app-558	180	59	karachi	karachi	PROPN
app-558	180	60	,	,	PUNCT
app-558	180	61	nasreen	nasreen	ADJ
app-558	180	62	jumani	jumani	PROPN
app-558	180	63	,	,	PUNCT
app-558	180	64	principal	principal	NOUN
app-558	180	65	,	,	PUNCT
app-558	180	66	govt	govt	NOUN
app-558	180	67	.	.	PUNCT
app-558	181	1	girls	girl	NOUN
app-558	181	2	higher	high	ADJ
app-558	181	3	secondary	secondary	ADJ
app-558	181	4	school	school	NOUN
app-558	181	5	and	and	CCONJ
app-558	181	6	mr	mr	PROPN
app-558	181	7	.	.	PROPN
app-558	181	8	tariq	tariq	PROPN
app-558	181	9	samuel	samuel	PROPN
app-558	181	10	and	and	CCONJ
app-558	181	11	mr	mr	PROPN
app-558	181	12	.	.	PROPN
app-558	181	13	yasir	yasir	PROPN
app-558	181	14	khursheed	khursheed	PROPN
app-558	181	15	from	from	ADP
app-558	181	16	darul	darul	NOUN
app-558	181	17	-	-	PUNCT
app-558	181	18	sukoon	sukoon	NOUN
app-558	181	19	,	,	PUNCT
app-558	181	20	karachi	karachi	PROPN
app-558	181	21	,	,	PUNCT
app-558	181	22	for	for	ADP
app-558	181	23	providing	provide	VERB
app-558	181	24	the	the	DET
app-558	181	25	samples	sample	NOUN
app-558	181	26	.	.	PUNCT
app-558	182	1	references	reference	NOUN
app-558	182	2	1	1	NUM
app-558	182	3	.	.	PUNCT
app-558	183	1	kreuzmann	kreuzmann	PROPN
app-558	183	2	d	d	PROPN
app-558	183	3	,	,	PUNCT
app-558	183	4	horstkorte	horstkorte	ADJ
app-558	183	5	r	r	NOUN
app-558	183	6	,	,	PUNCT
app-558	183	7	kohla	kohla	NOUN
app-558	183	8	g	g	PROPN
app-558	183	9	,	,	PUNCT
app-558	183	10	kannicht	kannicht	PROPN
app-558	183	11	c	c	PROPN
app-558	183	12	,	,	PUNCT
app-558	183	13	bennmann	bennmann	PROPN
app-558	183	14	d	d	PROPN
app-558	183	15	,	,	PUNCT
app-558	183	16	thate	thate	VERB
app-558	183	17	a	a	PRON
app-558	183	18	,	,	PUNCT
app-558	183	19	bork	bork	PROPN
app-558	183	20	k.	k.	PROPN
app-558	183	21	increased	increase	VERB
app-558	183	22	polysialylation	polysialylation	NOUN
app-558	183	23	of	of	ADP
app-558	183	24	the	the	DET
app-558	183	25	neural	neural	ADJ
app-558	183	26	cell	cell	NOUN
app-558	183	27	adhesion	adhesion	NOUN
app-558	183	28	molecule	molecule	NOUN
app-558	183	29	in	in	ADP
app-558	183	30	a	a	DET
app-558	183	31	transgenic	transgenic	NOUN
app-558	183	32	mouse	mouse	NOUN
app-558	183	33	model	model	NOUN
app-558	183	34	of	of	ADP
app-558	183	35	sialuria	sialuria	PROPN
app-558	183	36	.	.	PUNCT
app-558	184	1	chembiochem	chembiochem	PROPN
app-558	184	2	.	.	PUNCT
app-558	185	1	2017;18(13):1188	2017;18(13):1188	NUM
app-558	185	2	-	-	SYM
app-558	185	3	1193	1193	NUM
app-558	185	4	.	.	PUNCT
app-558	186	1	2	2	X
app-558	186	2	.	.	X
app-558	186	3	wen	wen	PROPN
app-558	186	4	xy	xy	PROPN
app-558	186	5	,	,	PUNCT
app-558	186	6	tarailo	tarailo	PROPN
app-558	186	7	-	-	PUNCT
app-558	186	8	graovac	graovac	NOUN
app-558	186	9	m	m	PROPN
app-558	186	10	,	,	PUNCT
app-558	186	11	brandarzamendi	brandarzamendi	VERB
app-558	186	12	k	k	PROPN
app-558	186	13	,	,	PUNCT
app-558	186	14	willems	willems	PROPN
app-558	186	15	a	a	PRON
app-558	186	16	,	,	PUNCT
app-558	186	17	rakic	rakic	PROPN
app-558	186	18	b	b	X
app-558	186	19	,	,	PUNCT
app-558	186	20	huijben	huijben	PROPN
app-558	187	1	k	k	PROPN
app-558	187	2	,	,	PUNCT
app-558	187	3	da	da	PROPN
app-558	187	4	silva	silva	PROPN
app-558	187	5	a	a	PROPN
app-558	187	6	,	,	PUNCT
app-558	187	7	pan	pan	NOUN
app-558	187	8	x	x	PROPN
app-558	187	9	,	,	PUNCT
app-558	187	10	el	el	PROPN
app-558	187	11	-	-	PUNCT
app-558	187	12	rass	rass	PROPN
app-558	187	13	s	s	PROPN
app-558	187	14	,	,	PUNCT
app-558	187	15	ng	ng	PROPN
app-558	187	16	r	r	PROPN
app-558	187	17	,	,	PUNCT
app-558	187	18	selby	selby	PROPN
app-558	187	19	k.	k.	PROPN
app-558	187	20	sialic	sialic	PROPN
app-558	187	21	acid	acid	PROPN
app-558	187	22	catabolism	catabolism	NOUN
app-558	187	23	by	by	ADP
app-558	187	24	n	n	CCONJ
app-558	187	25	-	-	PUNCT
app-558	187	26	acetylneuraminate	acetylneuraminate	ADJ
app-558	187	27	pyruvate	pyruvate	NOUN
app-558	187	28	lyase	lyase	NOUN
app-558	187	29	is	be	AUX
app-558	187	30	essential	essential	ADJ
app-558	187	31	for	for	ADP
app-558	187	32	muscle	muscle	NOUN
app-558	187	33	function	function	NOUN
app-558	187	34	.	.	PUNCT
app-558	188	1	jci	jci	PROPN
app-558	188	2	insight	insight	PROPN
app-558	188	3	.	.	PUNCT
app-558	188	4	2018;3(24	2018;3(24	NUM
app-558	188	5	)	)	PUNCT
app-558	188	6	.	.	PUNCT
app-558	189	1	3	3	X
app-558	189	2	.	.	X
app-558	189	3	bonfanti	bonfanti	PROPN
app-558	189	4	l.	l.	PROPN
app-558	189	5	psa	psa	PROPN
app-558	189	6	-	-	PUNCT
app-558	189	7	ncam	ncam	NOUN
app-558	189	8	in	in	ADP
app-558	189	9	mammalian	mammalian	ADJ
app-558	189	10	structural	structural	ADJ
app-558	189	11	plasticity	plasticity	NOUN
app-558	189	12	and	and	CCONJ
app-558	189	13	neurogenesis	neurogenesis	NOUN
app-558	189	14	.	.	PUNCT
app-558	190	1	progress	progress	NOUN
app-558	190	2	in	in	ADP
app-558	190	3	neurobiology	neurobiology	NOUN
app-558	190	4	.	.	PUNCT
app-558	191	1	2006;80(3):129164	2006;80(3):129164	NOUN
app-558	191	2	.	.	PUNCT
app-558	192	1	4	4	NUM
app-558	192	2	.	.	X
app-558	192	3	rutishauser	rutishauser	PROPN
app-558	192	4	u.	u.	PROPN
app-558	192	5	polysialic	polysialic	PROPN
app-558	192	6	acid	acid	PROPN
app-558	192	7	in	in	ADP
app-558	192	8	the	the	DET
app-558	192	9	plasticity	plasticity	NOUN
app-558	192	10	of	of	ADP
app-558	192	11	the	the	DET
app-558	192	12	developing	develop	VERB
app-558	192	13	and	and	CCONJ
app-558	192	14	adult	adult	NOUN
app-558	192	15	vertebrate	vertebrate	ADJ
app-558	192	16	nervous	nervous	ADJ
app-558	192	17	system	system	NOUN
app-558	192	18	.	.	PUNCT
app-558	193	1	nat	nat	PROPN
app-558	193	2	rev	rev	PROPN
app-558	193	3	neurosci	neurosci	PROPN
app-558	193	4	.	.	PUNCT
app-558	194	1	2008;9(1):26	2008;9(1):26	NUM
app-558	194	2	-	-	SYM
app-558	194	3	35	35	NUM
app-558	194	4	.	.	NOUN
app-558	195	1	5	5	NUM
app-558	195	2	.	.	X
app-558	195	3	ishtiaq	ishtiaq	PROPN
app-558	195	4	h	h	PROPN
app-558	195	5	,	,	PUNCT
app-558	195	6	siddiqui	siddiqui	NOUN
app-558	195	7	s	s	PART
app-558	195	8	,	,	PUNCT
app-558	195	9	nawaz	nawaz	ADJ
app-558	195	10	r	r	PROPN
app-558	195	11	,	,	PUNCT
app-558	195	12	jamali	jamali	PROPN
app-558	195	13	ks	ks	PROPN
app-558	195	14	,	,	PUNCT
app-558	195	15	khan	khan	PROPN
app-558	195	16	ag	ag	PROPN
app-558	195	17	.	.	PUNCT
app-558	195	18	sialuria	sialuria	PROPN
app-558	195	19	-	-	PUNCT
app-558	195	20	related	relate	VERB
app-558	195	21	intellectual	intellectual	ADJ
app-558	195	22	disability	disability	NOUN
app-558	195	23	in	in	ADP
app-558	195	24	children	child	NOUN
app-558	195	25	and	and	CCONJ
app-558	195	26	adolescent	adolescent	NOUN
app-558	195	27	of	of	ADP
app-558	195	28	pakistan	pakistan	PROPN
app-558	195	29	:	:	PUNCT
app-558	195	30	tenth	tenth	ADJ
app-558	195	31	patient	patient	NOUN
app-558	195	32	described	describe	VERB
app-558	195	33	has	have	VERB
app-558	195	34	a	a	DET
app-558	195	35	novel	novel	ADJ
app-558	195	36	mutation	mutation	NOUN
app-558	195	37	in	in	ADP
app-558	195	38	the	the	DET
app-558	195	39	gne	gne	PROPN
app-558	195	40	gene	gene	NOUN
app-558	195	41	.	.	PUNCT
app-558	196	1	cns	cns	PROPN
app-558	196	2	neurolog	neurolog	PROPN
app-558	196	3	dis	dis	PROPN
app-558	196	4	drug	drug	NOUN
app-558	196	5	targets	target	NOUN
app-558	196	6	.	.	PUNCT
app-558	197	1	2020;19(2):127	2020;19(2):127	NOUN
app-558	197	2	-	-	PUNCT
app-558	197	3	41	41	NUM
app-558	197	4	.	.	PUNCT
app-558	197	5	6	6	NUM
app-558	197	6	.	.	X
app-558	197	7	fontaine	fontaine	PROPN
app-558	197	8	g	g	PROPN
app-558	197	9	,	,	PUNCT
app-558	197	10	biserte	biserte	NOUN
app-558	197	11	g	g	NOUN
app-558	197	12	,	,	PUNCT
app-558	197	13	montreuil	montreuil	PROPN
app-558	197	14	j	j	PROPN
app-558	197	15	,	,	PUNCT
app-558	197	16	dupont	dupont	PROPN
app-558	197	17	a	a	PRON
app-558	197	18	,	,	PUNCT
app-558	197	19	farriaux	farriaux	NOUN
app-558	197	20	jp	jp	NOUN
app-558	197	21	.	.	PUNCT
app-558	198	1	la	la	PROPN
app-558	198	2	sialurie	sialurie	PROPN
app-558	198	3	:	:	PUNCT
app-558	198	4	un	un	PROPN
app-558	198	5	trouble	trouble	PROPN
app-558	198	6	métabolique	métabolique	VERB
app-558	198	7	original	original	ADJ
app-558	198	8	?	?	PUNCT
app-558	199	1	helv	helv	PROPN
app-558	199	2	paediatr	paediatr	PROPN
app-558	199	3	acta	acta	PROPN
app-558	199	4	suppl	suppl	PROPN
app-558	199	5	.	.	PUNCT
app-558	200	1	1968;17:1	1968;17:1	NUM
app-558	200	2	-	-	SYM
app-558	200	3	32	32	NUM
app-558	200	4	.	.	PUNCT
app-558	201	1	7	7	X
app-558	201	2	.	.	X
app-558	201	3	wilcken	wilcken	PROPN
app-558	201	4	b	b	PROPN
app-558	201	5	,	,	PUNCT
app-558	201	6	don	don	PROPN
app-558	201	7	n	n	CCONJ
app-558	201	8	,	,	PUNCT
app-558	201	9	greenaway	greenaway	PROPN
app-558	201	10	r	r	PROPN
app-558	201	11	,	,	PUNCT
app-558	201	12	hammond	hammond	PROPN
app-558	201	13	j	j	PROPN
app-558	201	14	,	,	PUNCT
app-558	201	15	sosula	sosula	VERB
app-558	201	16	l.	l.	PROPN
app-558	201	17	sialuria	sialuria	PROPN
app-558	201	18	:	:	PUNCT
app-558	201	19	a	a	DET
app-558	201	20	second	second	ADJ
app-558	201	21	case	case	NOUN
app-558	201	22	.	.	PUNCT
app-558	202	1	j	j	PROPN
app-558	202	2	inherit	inherit	VERB
app-558	202	3	metab	metab	PROPN
app-558	202	4	dis	dis	PROPN
app-558	202	5	.	.	PUNCT
app-558	203	1	1987;10(2):97102	1987;10(2):97102	NUM
app-558	203	2	.	.	NOUN
app-558	203	3	8	8	NUM
app-558	203	4	.	.	PUNCT
app-558	203	5	seppala	seppala	PROPN
app-558	203	6	r	r	NOUN
app-558	203	7	,	,	PUNCT
app-558	203	8	lehto	lehto	NOUN
app-558	203	9	vp	vp	NOUN
app-558	203	10	,	,	PUNCT
app-558	203	11	gahl	gahl	PROPN
app-558	203	12	wa	wa	PROPN
app-558	203	13	.	.	PUNCT
app-558	203	14	mutations	mutation	NOUN
app-558	203	15	in	in	ADP
app-558	203	16	the	the	DET
app-558	203	17	human	human	PROPN
app-558	203	18	udp	udp	PROPN
app-558	203	19	-	-	NOUN
app-558	203	20	nacetylglucosamine	nacetylglucosamine	ADJ
app-558	203	21	2	2	NUM
app-558	203	22	-	-	PUNCT
app-558	203	23	epimerase	epimerase	NOUN
app-558	203	24	gene	gene	NOUN
app-558	203	25	define	define	VERB
app-558	203	26	the	the	DET
app-558	203	27	disease	disease	NOUN
app-558	203	28	sialuria	sialuria	PROPN
app-558	203	29	and	and	CCONJ
app-558	203	30	the	the	DET
app-558	203	31	allosteric	allosteric	ADJ
app-558	203	32	site	site	NOUN
app-558	203	33	of	of	ADP
app-558	203	34	the	the	DET
app-558	203	35	enzyme	enzyme	NOUN
app-558	203	36	.	.	PUNCT
app-558	204	1	am	be	AUX
app-558	204	2	j	j	PROPN
app-558	204	3	hum	hum	PROPN
app-558	204	4	genet	genet	PROPN
app-558	204	5	.	.	PUNCT
app-558	205	1	1999;64(6):1563	1999;64(6):1563	PROPN
app-558	205	2	-	-	SYM
app-558	205	3	1569	1569	NUM
app-558	205	4	.	.	PUNCT
app-558	206	1	9	9	X
app-558	206	2	.	.	X
app-558	206	3	krasnewich	krasnewich	PROPN
app-558	206	4	dm	dm	PROPN
app-558	206	5	,	,	PUNCT
app-558	206	6	tietze	tietze	NOUN
app-558	206	7	fr	fr	PROPN
app-558	206	8	,	,	PUNCT
app-558	206	9	krause	krause	PROPN
app-558	206	10	wi	wi	PROPN
app-558	206	11	,	,	PUNCT
app-558	206	12	pretzlaff	pretzlaff	ADJ
app-558	206	13	r	r	NOUN
app-558	206	14	,	,	PUNCT
app-558	206	15	wenger	wenger	PROPN
app-558	206	16	da	da	PROPN
app-558	206	17	,	,	PUNCT
app-558	206	18	diwadkar	diwadkar	NOUN
app-558	206	19	v	v	NOUN
app-558	206	20	,	,	PUNCT
app-558	206	21	gahl	gahl	PROPN
app-558	206	22	wa	wa	PROPN
app-558	206	23	.	.	PROPN
app-558	206	24	clinical	clinical	ADJ
app-558	206	25	and	and	CCONJ
app-558	206	26	biochemical	biochemical	ADJ
app-558	206	27	studies	study	NOUN
app-558	206	28	in	in	ADP
app-558	206	29	an	an	DET
app-558	206	30	american	american	ADJ
app-558	206	31	child	child	NOUN
app-558	206	32	with	with	ADP
app-558	206	33	sialuria	sialuria	PROPN
app-558	206	34	.	.	PUNCT
app-558	207	1	j	j	PROPN
app-558	207	2	biochem	biochem	PROPN
app-558	207	3	med	me	VERB
app-558	207	4	metab	metab	PROPN
app-558	207	5	biol	biol	NOUN
app-558	207	6	.	.	PUNCT
app-558	208	1	1993;49(1):90	1993;49(1):90	NUM
app-558	208	2	-	-	SYM
app-558	208	3	96	96	NUM
app-558	208	4	.	.	PUNCT
app-558	209	1	10	10	NUM
app-558	209	2	.	.	PUNCT
app-558	210	1	ferreira	ferreira	PROPN
app-558	210	2	h	h	PROPN
app-558	210	3	,	,	PUNCT
app-558	210	4	seppala	seppala	ADJ
app-558	210	5	r	r	NOUN
app-558	210	6	,	,	PUNCT
app-558	210	7	pinto	pinto	NOUN
app-558	210	8	r	r	NOUN
app-558	210	9	,	,	PUNCT
app-558	210	10	huizing	huize	VERB
app-558	210	11	m	m	PRON
app-558	210	12	,	,	PUNCT
app-558	210	13	martins	martin	NOUN
app-558	210	14	e	e	NOUN
app-558	210	15	,	,	PUNCT
app-558	210	16	braga	braga	NOUN
app-558	210	17	ac	ac	PROPN
app-558	210	18	,	,	PUNCT
app-558	210	19	gomes	gomes	PROPN
app-558	210	20	l	l	PROPN
app-558	210	21	,	,	PUNCT
app-558	210	22	krasnewich	krasnewich	PROPN
app-558	210	23	dm	dm	PROPN
app-558	210	24	,	,	PUNCT
app-558	210	25	miranda	miranda	PROPN
app-558	210	26	mc	mc	PROPN
app-558	210	27	,	,	PUNCT
app-558	210	28	gahl	gahl	PROPN
app-558	210	29	wa	wa	PROPN
app-558	210	30	.	.	PUNCT
app-558	210	31	sialuria	sialuria	PROPN
app-558	210	32	in	in	ADP
app-558	210	33	a	a	DET
app-558	210	34	portuguese	portuguese	ADJ
app-558	210	35	girl	girl	NOUN
app-558	210	36	:	:	PUNCT
app-558	210	37	clinical	clinical	ADJ
app-558	210	38	,	,	PUNCT
app-558	210	39	biochemical	biochemical	ADJ
app-558	210	40	,	,	PUNCT
app-558	210	41	and	and	CCONJ
app-558	210	42	molecular	molecular	ADJ
app-558	210	43	characteristics	characteristic	NOUN
app-558	210	44	.	.	PUNCT
app-558	211	1	mol	mol	ADP
app-558	211	2	genet	genet	PROPN
app-558	211	3	metab	metab	NOUN
app-558	211	4	.	.	PUNCT
app-558	212	1	1999;67(2):131	1999;67(2):131	NUM
app-558	212	2	-	-	SYM
app-558	212	3	137	137	NUM
app-558	212	4	.	.	PUNCT
app-558	213	1	11	11	NUM
app-558	213	2	.	.	PUNCT
app-558	214	1	leroy	leroy	PROPN
app-558	214	2	jg	jg	PROPN
app-558	214	3	,	,	PUNCT
app-558	214	4	dacremont	dacremont	VERB
app-558	214	5	g	g	NOUN
app-558	214	6	,	,	PUNCT
app-558	214	7	desimpel	desimpel	NOUN
app-558	214	8	h	h	NOUN
app-558	214	9	,	,	PUNCT
app-558	214	10	van	van	PROPN
app-558	214	11	coster	coster	PROPN
app-558	214	12	r.	r.	PROPN
app-558	214	13	sialuria	sialuria	PROPN
app-558	214	14	(	(	PUNCT
app-558	214	15	french	french	ADJ
app-558	214	16	type	type	NOUN
app-558	214	17	):	):	PUNCT
app-558	214	18	new	new	ADJ
app-558	214	19	observation	observation	NOUN
app-558	214	20	of	of	ADP
app-558	214	21	this	this	DET
app-558	214	22	rare	rare	ADJ
app-558	214	23	disorder	disorder	NOUN
app-558	214	24	.	.	PUNCT
app-558	215	1	am	be	AUX
app-558	215	2	j	j	PROPN
app-558	215	3	hum	hum	PROPN
app-558	215	4	genet	genet	PROPN
app-558	215	5	.	.	PUNCT
app-558	216	1	1998;63	1998;63	NUM
app-558	216	2	:	:	PUNCT
app-558	216	3	a269	a269	PROPN
app-558	216	4	.	.	PROPN
app-558	216	5	12	12	NUM
app-558	216	6	.	.	PUNCT
app-558	217	1	penner	penner	PROPN
app-558	217	2	j	j	PROPN
app-558	217	3	,	,	PUNCT
app-558	217	4	mantey	mantey	PROPN
app-558	217	5	lr	lr	PROPN
app-558	217	6	,	,	PUNCT
app-558	217	7	elgavish	elgavish	PROPN
app-558	217	8	s	s	PROPN
app-558	217	9	,	,	PUNCT
app-558	217	10	ghaderi	ghaderi	NOUN
app-558	217	11	d	d	PROPN
app-558	217	12	,	,	PUNCT
app-558	217	13	cirak	cirak	PROPN
app-558	217	14	s	s	PROPN
app-558	217	15	,	,	PUNCT
app-558	217	16	berger	berger	PROPN
app-558	217	17	m	m	PROPN
app-558	217	18	,	,	PUNCT
app-558	217	19	krause	krause	PROPN
app-558	217	20	s	s	PROPN
app-558	217	21	,	,	PUNCT
app-558	217	22	lucka	lucka	PROPN
app-558	217	23	l	l	PROPN
app-558	217	24	,	,	PUNCT
app-558	217	25	voit	voit	PROPN
app-558	217	26	t	t	PROPN
app-558	217	27	,	,	PUNCT
app-558	217	28	mitrani	mitrani	PROPN
app-558	217	29	-	-	PUNCT
app-558	217	30	rosenbaum	rosenbaum	NOUN
app-558	217	31	s	s	PART
app-558	217	32	,	,	PUNCT
app-558	217	33	hinderlich	hinderlich	NOUN
app-558	217	34	s.	s.	PROPN
app-558	217	35	influence	influence	PROPN
app-558	217	36	of	of	ADP
app-558	217	37	udp	udp	NOUN
app-558	217	38	-	-	ADJ
app-558	217	39	glcnac	glcnac	ADJ
app-558	217	40	2	2	NUM
app-558	217	41	-	-	PUNCT
app-558	217	42	epimerase	epimerase	NOUN
app-558	217	43	/	/	SYM
app-558	217	44	mannac	mannac	PROPN
app-558	217	45	kinase	kinase	PROPN
app-558	217	46	mutant	mutant	ADJ
app-558	217	47	proteins	protein	NOUN
app-558	217	48	on	on	ADP
app-558	217	49	hereditary	hereditary	ADJ
app-558	217	50	inclusion	inclusion	NOUN
app-558	217	51	body	body	NOUN
app-558	217	52	myopathy	myopathy	ADJ
app-558	217	53	.	.	PUNCT
app-558	218	1	biochem	biochem	PROPN
app-558	218	2	.	.	PUNCT
app-558	219	1	2006;45(9):29682977	2006;45(9):29682977	NUM
app-558	219	2	.	.	PUNCT
app-558	220	1	13	13	NUM
app-558	220	2	.	.	PUNCT
app-558	221	1	huizing	huize	VERB
app-558	221	2	m	m	PRON
app-558	221	3	,	,	PUNCT
app-558	221	4	rakocevic	rakocevic	ADJ
app-558	221	5	g	g	NOUN
app-558	221	6	,	,	PUNCT
app-558	221	7	sparks	spark	VERB
app-558	221	8	se	se	PROPN
app-558	221	9	,	,	PUNCT
app-558	221	10	mamali	mamali	PROPN
app-558	221	11	i	i	PROPN
app-558	221	12	,	,	PUNCT
app-558	221	13	shatunov	shatunov	VERB
app-558	221	14	a	a	PRON
app-558	221	15	,	,	PUNCT
app-558	221	16	goldfarb	goldfarb	PROPN
app-558	221	17	l	l	PROPN
app-558	221	18	,	,	PUNCT
app-558	221	19	krasnewich	krasnewich	NOUN
app-558	221	20	d	d	NOUN
app-558	221	21	,	,	PUNCT
app-558	221	22	gahl	gahl	PROPN
app-558	221	23	wa	wa	PROPN
app-558	221	24	,	,	PUNCT
app-558	221	25	dalakas	dalakas	PROPN
app-558	221	26	mc	mc	PROPN
app-558	221	27	.	.	PROPN
app-558	221	28	hypoglycosylation	hypoglycosylation	PROPN
app-558	221	29	of	of	ADP
app-558	221	30	α	α	PROPN
app-558	221	31	-	-	NOUN
app-558	221	32	dystroglycan	dystroglycan	NOUN
app-558	221	33	in	in	ADP
app-558	221	34	patients	patient	NOUN
app-558	221	35	with	with	ADP
app-558	221	36	hereditary	hereditary	ADJ
app-558	221	37	ibm	ibm	PROPN
app-558	221	38	due	due	ADP
app-558	221	39	to	to	ADP
app-558	221	40	gne	gne	PROPN
app-558	221	41	mutations	mutation	NOUN
app-558	221	42	.	.	PUNCT
app-558	222	1	mol	mol	ADP
app-558	222	2	genet	genet	PROPN
app-558	222	3	metab	metab	NOUN
app-558	222	4	.	.	PUNCT
app-558	223	1	2004;81(3):196	2004;81(3):196	NUM
app-558	223	2	-	-	SYM
app-558	223	3	202	202	NUM
app-558	223	4	.	.	PUNCT
app-558	224	1	14	14	NUM
app-558	224	2	.	.	PUNCT
app-558	225	1	ricci	ricci	PROPN
app-558	225	2	e	e	PROPN
app-558	225	3	,	,	PUNCT
app-558	225	4	broccolini	broccolini	PROPN
app-558	225	5	a	a	PROPN
app-558	225	6	,	,	PUNCT
app-558	225	7	gidaro	gidaro	PROPN
app-558	225	8	t	t	PROPN
app-558	225	9	,	,	PUNCT
app-558	225	10	morosetti	morosetti	NOUN
app-558	225	11	r	r	NOUN
app-558	225	12	,	,	PUNCT
app-558	225	13	gliubizzi	gliubizzi	NOUN
app-558	225	14	c	c	NOUN
app-558	225	15	,	,	PUNCT
app-558	225	16	frusciante	frusciante	NOUN
app-558	225	17	r	r	PROPN
app-558	225	18	,	,	PUNCT
app-558	225	19	di	di	NOUN
app-558	225	20	lella	lella	NOUN
app-558	225	21	gm	gm	PROPN
app-558	225	22	,	,	PUNCT
app-558	225	23	tonali	tonali	PROPN
app-558	225	24	pa	pa	PROPN
app-558	225	25	,	,	PUNCT
app-558	225	26	mirabella	mirabella	PROPN
app-558	225	27	m.	m.	PROPN
app-558	225	28	ncam	ncam	PROPN
app-558	225	29	is	be	AUX
app-558	225	30	hyposialylated	hyposialylate	VERB
app-558	225	31	in	in	ADP
app-558	225	32	hereditary	hereditary	ADJ
app-558	225	33	inclusion	inclusion	NOUN
app-558	225	34	94	94	NUM
app-558	225	35	issn	issn	PROPN
app-558	225	36	2412	2412	NUM
app-558	225	37	-	-	SYM
app-558	225	38	3188	3188	NUM
app-558	225	39	(	(	PUNCT
app-558	225	40	online	online	NOUN
app-558	225	41	)	)	PUNCT
app-558	225	42	|	|	ADV
app-558	225	43	2410	2410	NUM
app-558	225	44	-	-	SYM
app-558	225	45	1354	1354	NUM
app-558	225	46	(	(	PUNCT
app-558	225	47	print	print	NOUN
app-558	225	48	)	)	PUNCT
app-558	225	49	app|	app|	NOUN
app-558	225	50	published	publish	VERB
app-558	225	51	by	by	ADP
app-558	225	52	aeirc|	aeirc|	ADP
app-558	225	53	volume	volume	NOUN
app-558	225	54	8	8	NUM
app-558	225	55	issue	issue	NOUN
app-558	225	56	2	2	NUM
app-558	225	57	body	body	NOUN
app-558	225	58	myopathy	myopathy	ADJ
app-558	225	59	due	due	ADP
app-558	225	60	to	to	ADP
app-558	225	61	gne	gne	PROPN
app-558	225	62	mutations	mutation	NOUN
app-558	225	63	.	.	PUNCT
app-558	226	1	neurology	neurology	NOUN
app-558	226	2	.	.	PUNCT
app-558	227	1	2006;66(5):755	2006;66(5):755	NUM
app-558	227	2	-	-	PUNCT
app-558	227	3	758	758	NUM
app-558	227	4	.	.	PUNCT
app-558	227	5	15	15	NUM
app-558	227	6	.	.	PUNCT
app-558	228	1	noguchi	noguchi	PROPN
app-558	228	2	s	s	PROPN
app-558	228	3	,	,	PUNCT
app-558	228	4	keira	keira	PROPN
app-558	228	5	y	y	PROPN
app-558	228	6	,	,	PUNCT
app-558	228	7	murayama	murayama	PROPN
app-558	228	8	k	k	PROPN
app-558	228	9	,	,	PUNCT
app-558	228	10	ogawa	ogawa	PROPN
app-558	228	11	m	m	PROPN
app-558	228	12	,	,	PUNCT
app-558	228	13	fujita	fujita	PROPN
app-558	228	14	m	m	PROPN
app-558	228	15	,	,	PUNCT
app-558	228	16	kawahara	kawahara	PROPN
app-558	228	17	g	g	PROPN
app-558	228	18	,	,	PUNCT
app-558	228	19	oya	oya	PROPN
app-558	228	20	y	y	PROPN
app-558	228	21	,	,	PUNCT
app-558	228	22	imazawa	imazawa	PROPN
app-558	228	23	m	m	PROPN
app-558	228	24	,	,	PUNCT
app-558	228	25	goto	goto	ADJ
app-558	228	26	yi	yi	PROPN
app-558	228	27	,	,	PUNCT
app-558	228	28	hayashi	hayashi	PROPN
app-558	228	29	yk	yk	PROPN
app-558	228	30	,	,	PUNCT
app-558	228	31	nonaka	nonaka	PROPN
app-558	228	32	i.	i.	PROPN
app-558	228	33	reduction	reduction	NOUN
app-558	228	34	of	of	ADP
app-558	228	35	udp	udp	NOUN
app-558	228	36	-	-	NOUN
app-558	228	37	nacetylglucosamine	nacetylglucosamine	ADJ
app-558	228	38	2	2	NUM
app-558	228	39	-	-	PUNCT
app-558	228	40	epimerase	epimerase	NOUN
app-558	228	41	/	/	SYM
app-558	228	42	nacetylmannosamine	nacetylmannosamine	NOUN
app-558	228	43	kinase	kinase	PROPN
app-558	228	44	activity	activity	NOUN
app-558	228	45	and	and	CCONJ
app-558	228	46	sialylation	sialylation	NOUN
app-558	228	47	in	in	ADP
app-558	228	48	distal	distal	ADJ
app-558	228	49	myopathy	myopathy	ADJ
app-558	228	50	with	with	ADP
app-558	228	51	rimmed	rimmed	ADJ
app-558	228	52	vacuoles	vacuole	NOUN
app-558	228	53	.	.	PUNCT
app-558	229	1	jbc	jbc	PROPN
app-558	229	2	.	.	PUNCT
app-558	230	1	2004;279(12):11402	2004;279(12):11402	NUM
app-558	230	2	-	-	PUNCT
app-558	230	3	11407	11407	NUM
app-558	230	4	.	.	PUNCT
app-558	231	1	16	16	NUM
app-558	231	2	.	.	PUNCT
app-558	232	1	bhatti	bhatti	PROPN
app-558	232	2	a	a	DET
app-558	232	3	,	,	PUNCT
app-558	232	4	ashfaq	ashfaq	ADJ
app-558	232	5	g.	g.	NOUN
app-558	232	6	frequency	frequency	NOUN
app-558	232	7	of	of	ADP
app-558	232	8	chromosomal	chromosomal	ADJ
app-558	232	9	anomalies	anomaly	NOUN
app-558	232	10	in	in	ADP
app-558	232	11	mentally	mentally	ADV
app-558	232	12	handicapped	handicapped	ADJ
app-558	232	13	children	child	NOUN
app-558	232	14	.	.	PUNCT
app-558	233	1	pak	pak	PROPN
app-558	233	2	j	j	PROPN
app-558	233	3	med	med	PROPN
app-558	233	4	res	re	NOUN
app-558	233	5	.	.	PUNCT
app-558	234	1	2008;47(1):47	2008;47(1):47	NUM
app-558	234	2	-	-	SYM
app-558	234	3	59	59	NUM
app-558	234	4	.	.	PUNCT
app-558	235	1	17	17	NUM
app-558	235	2	.	.	PUNCT
app-558	236	1	weidemann	weidemann	PROPN
app-558	236	2	w	w	PROPN
app-558	236	3	,	,	PUNCT
app-558	236	4	hering	hering	PROPN
app-558	236	5	j	j	NOUN
app-558	236	6	,	,	PUNCT
app-558	236	7	bennmann	bennmann	PROPN
app-558	236	8	d	d	PROPN
app-558	236	9	,	,	PUNCT
app-558	236	10	thate	thate	VERB
app-558	236	11	a	a	DET
app-558	236	12	,	,	PUNCT
app-558	236	13	horstkorte	horstkorte	PROPN
app-558	236	14	r.	r.	PROPN
app-558	236	15	the	the	DET
app-558	236	16	key	key	ADJ
app-558	236	17	enzyme	enzyme	NOUN
app-558	236	18	of	of	ADP
app-558	236	19	the	the	DET
app-558	236	20	sialic	sialic	ADJ
app-558	236	21	acid	acid	NOUN
app-558	236	22	metabolism	metabolism	NOUN
app-558	236	23	is	be	AUX
app-558	236	24	involved	involve	VERB
app-558	236	25	in	in	ADP
app-558	236	26	embryoid	embryoid	NUM
app-558	236	27	body	body	NOUN
app-558	236	28	formation	formation	NOUN
app-558	236	29	and	and	CCONJ
app-558	236	30	expression	expression	NOUN
app-558	236	31	of	of	ADP
app-558	236	32	marker	marker	NOUN
app-558	236	33	genes	gene	NOUN
app-558	236	34	of	of	ADP
app-558	236	35	germ	germ	NOUN
app-558	236	36	layer	layer	NOUN
app-558	236	37	formation	formation	NOUN
app-558	236	38	.	.	PUNCT
app-558	237	1	int	int	PROPN
app-558	237	2	j	j	PROPN
app-558	237	3	mol	mol	ADP
app-558	237	4	sci	sci	PROPN
app-558	237	5	.	.	PUNCT
app-558	238	1	2013;14(10):20555	2013;14(10):20555	NUM
app-558	238	2	-	-	SYM
app-558	238	3	20563	20563	NUM
app-558	238	4	.	.	PUNCT
app-558	239	1	18	18	NUM
app-558	239	2	.	.	PUNCT
app-558	240	1	weidemann	weidemann	PROPN
app-558	240	2	w	w	PROPN
app-558	240	3	,	,	PUNCT
app-558	240	4	hering	hering	PROPN
app-558	240	5	j	j	NOUN
app-558	240	6	,	,	PUNCT
app-558	240	7	bennmann	bennmann	PROPN
app-558	240	8	d	d	PROPN
app-558	240	9	,	,	PUNCT
app-558	240	10	thate	thate	VERB
app-558	240	11	a	a	DET
app-558	240	12	,	,	PUNCT
app-558	240	13	horstkorte	horstkorte	PROPN
app-558	240	14	r.	r.	PROPN
app-558	240	15	the	the	DET
app-558	240	16	key	key	ADJ
app-558	240	17	enzyme	enzyme	NOUN
app-558	240	18	of	of	ADP
app-558	240	19	the	the	DET
app-558	240	20	sialic	sialic	ADJ
app-558	240	21	acid	acid	NOUN
app-558	240	22	metabolism	metabolism	NOUN
app-558	240	23	is	be	AUX
app-558	240	24	involved	involve	VERB
app-558	240	25	in	in	ADP
app-558	240	26	embryoid	embryoid	NUM
app-558	240	27	body	body	NOUN
app-558	240	28	formation	formation	NOUN
app-558	240	29	and	and	CCONJ
app-558	240	30	expression	expression	NOUN
app-558	240	31	of	of	ADP
app-558	240	32	marker	marker	NOUN
app-558	240	33	genes	gene	NOUN
app-558	240	34	of	of	ADP
app-558	240	35	germ	germ	NOUN
app-558	240	36	layer	layer	NOUN
app-558	240	37	formation	formation	NOUN
app-558	240	38	.	.	PUNCT
app-558	241	1	int	int	PROPN
app-558	241	2	j	j	PROPN
app-558	241	3	mol	mol	ADP
app-558	241	4	sci	sci	PROPN
app-558	241	5	.	.	PUNCT
app-558	242	1	2013;14(10):20555	2013;14(10):20555	NUM
app-558	242	2	-	-	SYM
app-558	242	3	20563	20563	NUM
app-558	242	4	.	.	PUNCT
app-558	243	1	19	19	NUM
app-558	243	2	.	.	PUNCT
app-558	244	1	sewell	sewell	PROPN
app-558	244	2	ac	ac	PROPN
app-558	244	3	,	,	PUNCT
app-558	244	4	poets	poet	NOUN
app-558	244	5	cf	cf	NOUN
app-558	244	6	,	,	PUNCT
app-558	244	7	degen	degen	PROPN
app-558	244	8	i	i	PROPN
app-558	244	9	,	,	PUNCT
app-558	244	10	stöß	stöß	ADJ
app-558	244	11	h	h	NOUN
app-558	244	12	,	,	PUNCT
app-558	244	13	pontz	pontz	PROPN
app-558	244	14	bf	bf	NOUN
app-558	244	15	.	.	PUNCT
app-558	245	1	the	the	DET
app-558	245	2	spectrum	spectrum	NOUN
app-558	245	3	of	of	ADP
app-558	245	4	free	free	ADJ
app-558	245	5	neuraminic	neuraminic	ADJ
app-558	245	6	acid	acid	NOUN
app-558	245	7	storage	storage	NOUN
app-558	245	8	disease	disease	NOUN
app-558	245	9	in	in	ADP
app-558	245	10	childhood	childhood	NOUN
app-558	245	11	:	:	PUNCT
app-558	245	12	clinical	clinical	ADJ
app-558	245	13	,	,	PUNCT
app-558	245	14	morphological	morphological	ADJ
app-558	245	15	and	and	CCONJ
app-558	245	16	biochemical	biochemical	ADJ
app-558	245	17	observations	observation	NOUN
app-558	245	18	in	in	ADP
app-558	245	19	three	three	NUM
app-558	245	20	non‐	non‐	ADJ
app-558	245	21	finnish	finnish	ADJ
app-558	245	22	patients	patient	NOUN
app-558	245	23	.	.	PUNCT
app-558	246	1	am	be	AUX
app-558	246	2	j	j	PROPN
app-558	246	3	med	med	PROPN
app-558	246	4	genet	genet	PROPN
app-558	246	5	.	.	PUNCT
app-558	247	1	1996;63(1):203	1996;63(1):203	NUM
app-558	247	2	-	-	PUNCT
app-558	247	3	208	208	NUM
app-558	247	4	.	.	PUNCT
app-558	248	1	20	20	NUM
app-558	248	2	.	.	PUNCT
app-558	249	1	mancini	mancini	PROPN
app-558	249	2	gm	gm	PROPN
app-558	249	3	,	,	PUNCT
app-558	249	4	verheijen	verheijen	PROPN
app-558	249	5	fw	fw	PROPN
app-558	249	6	,	,	PUNCT
app-558	249	7	beerens	beerens	PROPN
app-558	249	8	ce	ce	PROPN
app-558	249	9	,	,	PUNCT
app-558	249	10	renlund	renlund	PROPN
app-558	249	11	m	m	PROPN
app-558	249	12	,	,	PUNCT
app-558	249	13	aula	aula	PROPN
app-558	249	14	p.	p.	PROPN
app-558	249	15	sialic	sialic	PROPN
app-558	249	16	acid	acid	NOUN
app-558	249	17	storage	storage	NOUN
app-558	249	18	disorders	disorder	NOUN
app-558	249	19	:	:	PUNCT
app-558	249	20	observations	observation	NOUN
app-558	249	21	on	on	ADP
app-558	249	22	clinical	clinical	ADJ
app-558	249	23	and	and	CCONJ
app-558	249	24	biochemical	biochemical	ADJ
app-558	249	25	variation	variation	NOUN
app-558	249	26	.	.	PUNCT
app-558	250	1	dev	dev	PROPN
app-558	250	2	neurosci	neurosci	PROPN
app-558	250	3	.	.	PUNCT
app-558	251	1	1991;13(4	1991;13(4	NUM
app-558	251	2	-	-	SYM
app-558	251	3	5):327	5):327	NUM
app-558	251	4	-	-	PUNCT
app-558	251	5	330	330	NUM
app-558	251	6	.	.	PUNCT
app-558	251	7	21	21	NUM
app-558	251	8	.	.	PUNCT
app-558	252	1	seppala	seppala	PROPN
app-558	252	2	r	r	NOUN
app-558	252	3	,	,	PUNCT
app-558	252	4	tietze	tietze	NOUN
app-558	252	5	f	f	NOUN
app-558	252	6	,	,	PUNCT
app-558	252	7	krasnewich	krasnewich	PROPN
app-558	252	8	d	d	PROPN
app-558	252	9	,	,	PUNCT
app-558	252	10	weiss	weiss	PROPN
app-558	252	11	p	p	X
app-558	252	12	,	,	PUNCT
app-558	252	13	ashwell	ashwell	PROPN
app-558	252	14	g	g	NOUN
app-558	252	15	,	,	PUNCT
app-558	252	16	barsh	barsh	NOUN
app-558	252	17	g	g	NOUN
app-558	252	18	,	,	PUNCT
app-558	252	19	thomas	thomas	PROPN
app-558	252	20	gh	gh	PROPN
app-558	252	21	,	,	PUNCT
app-558	252	22	packman	packman	NOUN
app-558	252	23	s	s	PROPN
app-558	252	24	,	,	PUNCT
app-558	252	25	gahl	gahl	PROPN
app-558	252	26	wa	wa	PROPN
app-558	252	27	.	.	PROPN
app-558	252	28	sialic	sialic	PROPN
app-558	252	29	acid	acid	NOUN
app-558	252	30	metabolism	metabolism	NOUN
app-558	252	31	in	in	ADP
app-558	252	32	sialuria	sialuria	PROPN
app-558	252	33	fibroblasts	fibroblast	NOUN
app-558	252	34	.	.	PUNCT
app-558	253	1	j	j	PROPN
app-558	253	2	biol	biol	PROPN
app-558	253	3	chem	chem	NOUN
app-558	253	4	.	.	PUNCT
app-558	254	1	1991;266(12):7456	1991;266(12):7456	NUM
app-558	254	2	-	-	SYM
app-558	254	3	7461	7461	NUM
app-558	254	4	.	.	PUNCT
app-558	255	1	22	22	NUM
app-558	255	2	.	.	PUNCT
app-558	256	1	krasnewich	krasnewich	PROPN
app-558	256	2	dm	dm	PROPN
app-558	256	3	,	,	PUNCT
app-558	256	4	tietze	tietze	NOUN
app-558	256	5	fr	fr	PROPN
app-558	256	6	,	,	PUNCT
app-558	256	7	krause	krause	PROPN
app-558	256	8	wi	wi	PROPN
app-558	256	9	,	,	PUNCT
app-558	256	10	pretzlaff	pretzlaff	ADJ
app-558	256	11	r	r	NOUN
app-558	256	12	,	,	PUNCT
app-558	256	13	wenger	wenger	PROPN
app-558	256	14	da	da	PROPN
app-558	256	15	,	,	PUNCT
app-558	256	16	diwadkar	diwadkar	NOUN
app-558	256	17	v	v	NOUN
app-558	256	18	,	,	PUNCT
app-558	256	19	gahl	gahl	PROPN
app-558	256	20	wa	wa	PROPN
app-558	256	21	.	.	PROPN
app-558	257	1	clinical	clinical	ADJ
app-558	257	2	and	and	CCONJ
app-558	257	3	biochemical	biochemical	ADJ
app-558	257	4	studies	study	NOUN
app-558	257	5	in	in	ADP
app-558	257	6	an	an	DET
app-558	257	7	american	american	ADJ
app-558	257	8	child	child	NOUN
app-558	257	9	with	with	ADP
app-558	257	10	sialuria	sialuria	PROPN
app-558	257	11	.	.	PUNCT
app-558	258	1	j	j	PROPN
app-558	258	2	biochem	biochem	PROPN
app-558	258	3	med	me	VERB
app-558	258	4	metab	metab	PROPN
app-558	258	5	biol	biol	NOUN
app-558	258	6	.	.	PUNCT
app-558	259	1	1993;49(1):90	1993;49(1):90	NUM
app-558	259	2	-	-	SYM
app-558	259	3	96	96	NUM
app-558	259	4	.	.	PUNCT
app-558	260	1	23	23	NUM
app-558	260	2	.	.	PUNCT
app-558	261	1	leroy	leroy	PROPN
app-558	261	2	jg	jg	PROPN
app-558	261	3	,	,	PUNCT
app-558	261	4	seppala	seppala	PROPN
app-558	261	5	r	r	NOUN
app-558	261	6	,	,	PUNCT
app-558	261	7	huizing	huize	VERB
app-558	261	8	m	m	PRON
app-558	261	9	,	,	PUNCT
app-558	261	10	dacremont	dacremont	VERB
app-558	261	11	g	g	NOUN
app-558	261	12	,	,	PUNCT
app-558	261	13	de	de	PROPN
app-558	261	14	simpel	simpel	PROPN
app-558	261	15	h	h	PROPN
app-558	261	16	,	,	PUNCT
app-558	261	17	van	van	PROPN
app-558	261	18	coster	coster	PROPN
app-558	261	19	rn	rn	PROPN
app-558	261	20	,	,	PUNCT
app-558	261	21	orvisky	orvisky	NOUN
app-558	261	22	e	e	NOUN
app-558	261	23	,	,	PUNCT
app-558	261	24	krasnewich	krasnewich	NOUN
app-558	261	25	dm	dm	PROPN
app-558	261	26	,	,	PUNCT
app-558	261	27	gahl	gahl	PROPN
app-558	261	28	wa	wa	INTJ
app-558	261	29	.	.	PUNCT
app-558	262	1	dominant	dominant	ADJ
app-558	262	2	inheritance	inheritance	NOUN
app-558	262	3	of	of	ADP
app-558	262	4	sialuria	sialuria	PROPN
app-558	262	5	,	,	PUNCT
app-558	262	6	an	an	DET
app-558	262	7	inborn	inborn	ADJ
app-558	262	8	error	error	NOUN
app-558	262	9	of	of	ADP
app-558	262	10	feedback	feedback	NOUN
app-558	262	11	inhibition	inhibition	NOUN
app-558	262	12	.	.	PUNCT
app-558	263	1	am	be	AUX
app-558	263	2	j	j	PROPN
app-558	263	3	hum	hum	PROPN
app-558	263	4	genet	genet	PROPN
app-558	263	5	.	.	PUNCT
app-558	264	1	2001;68(6):1419	2001;68(6):1419	NUM
app-558	264	2	-	-	SYM
app-558	264	3	1427	1427	NUM
app-558	264	4	.	.	PUNCT
app-558	265	1	24	24	NUM
app-558	265	2	.	.	PUNCT
app-558	266	1	nonaka	nonaka	PROPN
app-558	266	2	i	i	PROPN
app-558	266	3	,	,	PUNCT
app-558	266	4	sunohara	sunohara	PROPN
app-558	266	5	n	n	CCONJ
app-558	266	6	,	,	PUNCT
app-558	266	7	ishiura	ishiura	PROPN
app-558	266	8	s	s	PROPN
app-558	266	9	,	,	PUNCT
app-558	266	10	satoyoshi	satoyoshi	PROPN
app-558	266	11	e.	e.	PROPN
app-558	266	12	familial	familial	PROPN
app-558	266	13	distal	distal	ADJ
app-558	266	14	myopathy	myopathy	ADJ
app-558	266	15	with	with	ADP
app-558	266	16	rimmed	rimmed	ADJ
app-558	266	17	vacuole	vacuole	NOUN
app-558	266	18	and	and	CCONJ
app-558	266	19	lamellar	lamellar	ADJ
app-558	266	20	(	(	PUNCT
app-558	266	21	myeloid	myeloid	NOUN
app-558	266	22	)	)	PUNCT
app-558	266	23	body	body	NOUN
app-558	266	24	formation	formation	NOUN
app-558	266	25	.	.	PUNCT
app-558	267	1	j	j	PROPN
app-558	267	2	neurol	neurol	PROPN
app-558	267	3	sci	sci	PROPN
app-558	267	4	.	.	PUNCT
app-558	268	1	1981;51(1):141	1981;51(1):141	NUM
app-558	268	2	-	-	SYM
app-558	268	3	155	155	NUM
app-558	268	4	.	.	PUNCT
app-558	269	1	25	25	NUM
app-558	269	2	.	.	PUNCT
app-558	269	3	asaka	asaka	PROPN
app-558	269	4	t	t	PROPN
app-558	269	5	,	,	PUNCT
app-558	269	6	ikeuchi	ikeuchi	PROPN
app-558	269	7	k	k	PROPN
app-558	269	8	,	,	PUNCT
app-558	269	9	okino	okino	PROPN
app-558	269	10	s	s	PROPN
app-558	269	11	,	,	PUNCT
app-558	269	12	takizawa	takizawa	PROPN
app-558	269	13	y	y	PROPN
app-558	269	14	,	,	PUNCT
app-558	269	15	satake	satake	VERB
app-558	269	16	r	r	NOUN
app-558	269	17	,	,	PUNCT
app-558	269	18	nitta	nitta	ADJ
app-558	269	19	e	e	NOUN
app-558	269	20	,	,	PUNCT
app-558	269	21	komai	komai	PROPN
app-558	269	22	k	k	PROPN
app-558	269	23	,	,	PUNCT
app-558	269	24	endo	endo	PROPN
app-558	269	25	k	k	NOUN
app-558	269	26	,	,	PUNCT
app-558	269	27	higuchi	higuchi	PROPN
app-558	269	28	s	s	PROPN
app-558	269	29	,	,	PUNCT
app-558	269	30	oyake	oyake	PROPN
app-558	269	31	t	t	PROPN
app-558	269	32	,	,	PUNCT
app-558	269	33	yoshimura	yoshimura	NOUN
app-558	269	34	t.	t.	NOUN
app-558	269	35	homozygosity	homozygosity	NOUN
app-558	269	36	and	and	CCONJ
app-558	269	37	linkage	linkage	NOUN
app-558	269	38	disequilibrium	disequilibrium	NOUN
app-558	269	39	mapping	mapping	NOUN
app-558	269	40	of	of	ADP
app-558	269	41	autosomal	autosomal	ADJ
app-558	269	42	recessive	recessive	ADJ
app-558	269	43	distal	distal	ADJ
app-558	269	44	myopathy	myopathy	ADJ
app-558	269	45	(	(	PUNCT
app-558	269	46	nonaka	nonaka	X
app-558	269	47	distal	distal	PROPN
app-558	269	48	myopathy	myopathy	ADJ
app-558	269	49	)	)	PUNCT
app-558	269	50	.	.	PUNCT
app-558	270	1	j	j	PROPN
app-558	270	2	human	human	ADJ
app-558	270	3	genetics	genetics	PROPN
app-558	270	4	.	.	PUNCT
app-558	271	1	2001;46(11):649	2001;46(11):649	NUM
app-558	271	2	-	-	PUNCT
app-558	271	3	655	655	NUM
app-558	271	4	.	.	PUNCT
app-558	272	1	26	26	NUM
app-558	272	2	.	.	PUNCT
app-558	272	3	celeste	celeste	PROPN
app-558	272	4	fv	fv	PROPN
app-558	272	5	,	,	PUNCT
app-558	272	6	vilboux	vilboux	ADJ
app-558	272	7	t	t	PROPN
app-558	272	8	,	,	PUNCT
app-558	272	9	ciccone	ciccone	PROPN
app-558	272	10	c	c	X
app-558	272	11	,	,	PUNCT
app-558	272	12	de	de	X
app-558	272	13	dios	dios	X
app-558	272	14	jk	jk	PROPN
app-558	272	15	,	,	PUNCT
app-558	272	16	malicdan	malicdan	PROPN
app-558	272	17	mc	mc	PROPN
app-558	272	18	,	,	PUNCT
app-558	272	19	leoyklang	leoyklang	PROPN
app-558	272	20	p	p	NOUN
app-558	272	21	,	,	PUNCT
app-558	272	22	mckew	mckew	NOUN
app-558	272	23	jc	jc	PROPN
app-558	272	24	,	,	PUNCT
app-558	272	25	gahl	gahl	PROPN
app-558	272	26	wa	wa	PROPN
app-558	272	27	,	,	PUNCT
app-558	272	28	carrillo‐carrasco	carrillo‐carrasco	PROPN
app-558	272	29	n	n	CCONJ
app-558	272	30	,	,	PUNCT
app-558	272	31	huizing	huize	VERB
app-558	272	32	m.	m.	NOUN
app-558	272	33	mutation	mutation	NOUN
app-558	272	34	update	update	NOUN
app-558	272	35	for	for	ADP
app-558	272	36	gne	gne	PROPN
app-558	272	37	gene	gene	NOUN
app-558	272	38	variants	variant	NOUN
app-558	272	39	associated	associate	VERB
app-558	272	40	with	with	ADP
app-558	272	41	gne	gne	PROPN
app-558	272	42	myopathy	myopathy	PROPN
app-558	272	43	.	.	PUNCT
app-558	273	1	human	human	ADJ
app-558	273	2	mutation	mutation	NOUN
app-558	273	3	.	.	PUNCT
app-558	274	1	2014;35(8):915	2014;35(8):915	NUM
app-558	274	2	-	-	SYM
app-558	274	3	26	26	NUM
app-558	274	4	.	.	PUNCT
app-558	275	1	27	27	NUM
app-558	275	2	.	.	PUNCT
app-558	276	1	nishino	nishino	PROPN
app-558	276	2	i	i	PROPN
app-558	276	3	,	,	PUNCT
app-558	276	4	carrillo	carrillo	PROPN
app-558	276	5	-	-	PUNCT
app-558	276	6	carrasco	carrasco	PROPN
app-558	276	7	n	n	CCONJ
app-558	276	8	,	,	PUNCT
app-558	276	9	argov	argov	ADJ
app-558	276	10	z.	z.	PROPN
app-558	276	11	gne	gne	PROPN
app-558	276	12	myopathy	myopathy	PROPN
app-558	276	13	:	:	PUNCT
app-558	276	14	current	current	ADJ
app-558	276	15	update	update	NOUN
app-558	276	16	and	and	CCONJ
app-558	276	17	future	future	ADJ
app-558	276	18	therapy	therapy	NOUN
app-558	276	19	.	.	PUNCT
app-558	277	1	j	j	PROPN
app-558	277	2	neurol	neurol	PROPN
app-558	277	3	neurosurg	neurosurg	PROPN
app-558	277	4	psychiatry	psychiatry	PROPN
app-558	277	5	.	.	PUNCT
app-558	278	1	2015;86(4):385	2015;86(4):385	NUM
app-558	278	2	-	-	PUNCT
app-558	278	3	392	392	NUM
app-558	278	4	.	.	NOUN
app-558	278	5	28	28	NUM
app-558	278	6	.	.	PUNCT
app-558	279	1	hinderlich	hinderlich	PROPN
app-558	279	2	s	s	PROPN
app-558	279	3	,	,	PUNCT
app-558	279	4	salama	salama	PROPN
app-558	280	1	i	i	PRON
app-558	280	2	,	,	PUNCT
app-558	280	3	eisenberg	eisenberg	PROPN
app-558	280	4	i	i	PRON
app-558	280	5	,	,	PUNCT
app-558	280	6	potikha	potikha	PROPN
app-558	280	7	t	t	PROPN
app-558	280	8	,	,	PUNCT
app-558	280	9	mantey	mantey	PROPN
app-558	280	10	lr	lr	PROPN
app-558	280	11	,	,	PUNCT
app-558	280	12	yarema	yarema	X
app-558	280	13	kj	kj	PROPN
app-558	280	14	,	,	PUNCT
app-558	280	15	horstkorte	horstkorte	ADJ
app-558	280	16	r	r	NOUN
app-558	280	17	,	,	PUNCT
app-558	280	18	argov	argov	ADJ
app-558	280	19	z	z	PROPN
app-558	280	20	,	,	PUNCT
app-558	280	21	sadeh	sadeh	PROPN
app-558	280	22	m	m	PROPN
app-558	280	23	,	,	PUNCT
app-558	280	24	reutter	reutter	PROPN
app-558	280	25	w	w	PROPN
app-558	280	26	,	,	PUNCT
app-558	280	27	mitrani	mitrani	ADJ
app-558	280	28	-	-	PUNCT
app-558	280	29	rosenbaum	rosenbaum	PROPN
app-558	280	30	s.	s.	PROPN
app-558	280	31	the	the	DET
app-558	280	32	homozygous	homozygous	ADJ
app-558	280	33	m712	m712	PROPN
app-558	280	34	t	t	NOUN
app-558	280	35	mutation	mutation	NOUN
app-558	280	36	of	of	ADP
app-558	280	37	udpn	udpn	ADJ
app-558	280	38	-	-	PUNCT
app-558	280	39	acetylglucosamine	acetylglucosamine	ADJ
app-558	280	40	2	2	NUM
app-558	280	41	-	-	PUNCT
app-558	280	42	epimerase	epimerase	NOUN
app-558	280	43	/	/	SYM
app-558	280	44	nacetylmannosamine	nacetylmannosamine	PROPN
app-558	280	45	kinase	kinase	PROPN
app-558	280	46	results	result	VERB
app-558	280	47	in	in	ADP
app-558	280	48	reduced	reduce	VERB
app-558	280	49	enzyme	enzyme	NOUN
app-558	280	50	activities	activity	NOUN
app-558	280	51	but	but	CCONJ
app-558	280	52	not	not	PART
app-558	280	53	in	in	ADP
app-558	280	54	altered	altered	ADJ
app-558	280	55	overall	overall	ADJ
app-558	280	56	cellular	cellular	ADJ
app-558	280	57	sialylation	sialylation	NOUN
app-558	280	58	in	in	ADP
app-558	280	59	hereditary	hereditary	ADJ
app-558	280	60	inclusion	inclusion	NOUN
app-558	280	61	body	body	NOUN
app-558	280	62	myopathy	myopathy	ADJ
app-558	280	63	.	.	PUNCT
app-558	281	1	febs	febs	NOUN
app-558	281	2	letters	letter	NOUN
app-558	281	3	.	.	PUNCT
app-558	282	1	2004;566(1	2004;566(1	NUM
app-558	282	2	-	-	PUNCT
app-558	282	3	3):105	3):105	NUM
app-558	282	4	-	-	PUNCT
app-558	282	5	109	109	NUM
app-558	282	6	.	.	PUNCT
app-558	282	7	95	95	NUM
app-558	282	8	issn	issn	VERB
app-558	282	9	2412	2412	NUM
app-558	282	10	-	-	SYM
app-558	282	11	3188	3188	NUM
app-558	282	12	(	(	PUNCT
app-558	282	13	online	online	NOUN
app-558	282	14	)	)	PUNCT
app-558	282	15	|	|	ADV
app-558	282	16	2410	2410	NUM
app-558	282	17	-	-	SYM
app-558	282	18	1354	1354	NUM
app-558	282	19	(	(	PUNCT
app-558	282	20	print	print	NOUN
app-558	282	21	)	)	PUNCT
app-558	282	22	app|	app|	NOUN
app-558	282	23	published	publish	VERB
app-558	282	24	by	by	ADP
app-558	282	25	aeirc|	aeirc|	ADP
app-558	282	26	volume	volume	NOUN
app-558	282	27	8	8	NUM
app-558	282	28	issue	issue	NOUN
app-558	282	29	2	2	NUM
app-558	282	30	29	29	NUM
app-558	282	31	.	.	PUNCT
app-558	283	1	salama	salama	NOUN
app-558	283	2	i	i	PRON
app-558	283	3	,	,	PUNCT
app-558	283	4	hinderlich	hinderlich	NOUN
app-558	283	5	s	s	PROPN
app-558	283	6	,	,	PUNCT
app-558	283	7	shlomai	shlomai	ADJ
app-558	283	8	z	z	PROPN
app-558	283	9	,	,	PUNCT
app-558	283	10	eisenberg	eisenberg	PROPN
app-558	283	11	i	i	PRON
app-558	283	12	,	,	PUNCT
app-558	283	13	krause	krause	PROPN
app-558	283	14	s	s	PROPN
app-558	283	15	,	,	PUNCT
app-558	283	16	yarema	yarema	X
app-558	283	17	k	k	NOUN
app-558	283	18	,	,	PUNCT
app-558	283	19	argov	argov	ADJ
app-558	283	20	z	z	PROPN
app-558	283	21	,	,	PUNCT
app-558	283	22	lochmuller	lochmuller	ADJ
app-558	283	23	h	h	NOUN
app-558	283	24	,	,	PUNCT
app-558	283	25	reutter	reutter	PROPN
app-558	283	26	w	w	PROPN
app-558	283	27	,	,	PUNCT
app-558	283	28	dabby	dabby	ADJ
app-558	283	29	r	r	NOUN
app-558	283	30	,	,	PUNCT
app-558	283	31	sadeh	sadeh	ADJ
app-558	283	32	m.	m.	NOUN
app-558	283	33	no	no	DET
app-558	283	34	overall	overall	ADJ
app-558	283	35	hyposialylation	hyposialylation	NOUN
app-558	283	36	in	in	ADP
app-558	283	37	hereditary	hereditary	ADJ
app-558	283	38	inclusion	inclusion	NOUN
app-558	283	39	body	body	NOUN
app-558	283	40	myopathy	myopathy	ADJ
app-558	283	41	myoblasts	myoblast	NOUN
app-558	283	42	carrying	carry	VERB
app-558	283	43	the	the	DET
app-558	283	44	homozygous	homozygous	ADJ
app-558	283	45	m712	m712	PROPN
app-558	283	46	t	t	NOUN
app-558	283	47	gne	gne	PROPN
app-558	283	48	mutation	mutation	PROPN
app-558	283	49	.	.	PUNCT
app-558	284	1	biochem	biochem	PROPN
app-558	284	2	biophys	biophy	VERB
app-558	284	3	res	re	NOUN
app-558	284	4	commun	commun	PROPN
app-558	284	5	.	.	PUNCT
app-558	285	1	2005;328(1):221	2005;328(1):221	PROPN
app-558	285	2	-	-	SYM
app-558	285	3	226	226	NUM
app-558	285	4	.	.	PUNCT
app-558	285	5	30	30	NUM
app-558	285	6	.	.	PUNCT
app-558	286	1	saito	saito	PROPN
app-558	286	2	f	f	PROPN
app-558	286	3	,	,	PUNCT
app-558	286	4	tomimitsu	tomimitsu	NOUN
app-558	286	5	h	h	NOUN
app-558	286	6	,	,	PUNCT
app-558	286	7	arai	arai	PROPN
app-558	286	8	k	k	PROPN
app-558	286	9	,	,	PUNCT
app-558	286	10	nakai	nakai	PROPN
app-558	286	11	s	s	PROPN
app-558	286	12	,	,	PUNCT
app-558	286	13	kanda	kanda	PROPN
app-558	286	14	t	t	PROPN
app-558	286	15	,	,	PUNCT
app-558	286	16	shimizu	shimizu	PROPN
app-558	286	17	t	t	PROPN
app-558	286	18	,	,	PUNCT
app-558	286	19	mizusawa	mizusawa	PROPN
app-558	286	20	h	h	NOUN
app-558	286	21	,	,	PUNCT
app-558	286	22	matsumura	matsumura	PROPN
app-558	286	23	k.	k.	PROPN
app-558	287	1	a	a	DET
app-558	287	2	japanese	japanese	ADJ
app-558	287	3	patient	patient	NOUN
app-558	287	4	with	with	ADP
app-558	287	5	distal	distal	ADJ
app-558	287	6	myopathy	myopathy	ADJ
app-558	287	7	with	with	ADP
app-558	287	8	rimmed	rimmed	ADJ
app-558	287	9	vacuoles	vacuole	NOUN
app-558	287	10	:	:	PUNCT
app-558	287	11	missense	missense	VERB
app-558	287	12	mutations	mutation	NOUN
app-558	287	13	in	in	ADP
app-558	287	14	the	the	DET
app-558	287	15	epimerase	epimerase	NOUN
app-558	287	16	domain	domain	NOUN
app-558	287	17	of	of	ADP
app-558	287	18	the	the	DET
app-558	287	19	udp	udp	NOUN
app-558	287	20	-	-	NOUN
app-558	287	21	nacetylglucosamine	nacetylglucosamine	ADJ
app-558	287	22	2	2	NUM
app-558	287	23	-	-	PUNCT
app-558	287	24	epimerase	epimerase	NOUN
app-558	287	25	/	/	SYM
app-558	287	26	nacetylmannosamine	nacetylmannosamine	NOUN
app-558	287	27	kinase	kinase	PROPN
app-558	287	28	(	(	PUNCT
app-558	287	29	gne	gne	PROPN
app-558	287	30	)	)	PUNCT
app-558	287	31	gene	gene	NOUN
app-558	287	32	accompanied	accompany	VERB
app-558	287	33	by	by	ADP
app-558	287	34	hyposialylation	hyposialylation	NOUN
app-558	287	35	of	of	ADP
app-558	287	36	skeletal	skeletal	ADJ
app-558	287	37	muscle	muscle	NOUN
app-558	287	38	glycoproteins	glycoprotein	NOUN
app-558	287	39	.	.	PUNCT
app-558	288	1	neuromuscul	neuromuscul	PROPN
app-558	288	2	disord	disord	PROPN
app-558	288	3	.	.	PUNCT
app-558	289	1	2004;14(2):158161	2004;14(2):158161	NUM
app-558	289	2	.	.	X
app-558	289	3	31	31	NUM
app-558	289	4	.	.	PUNCT
app-558	290	1	malicdan	malicdan	PROPN
app-558	290	2	mc	mc	PROPN
app-558	290	3	,	,	PUNCT
app-558	290	4	noguchi	noguchi	PROPN
app-558	290	5	s	s	PROPN
app-558	290	6	,	,	PUNCT
app-558	290	7	nonaka	nonaka	PROPN
app-558	290	8	i	i	PROPN
app-558	290	9	,	,	PUNCT
app-558	290	10	hayashi	hayashi	PROPN
app-558	290	11	yk	yk	PROPN
app-558	290	12	,	,	PUNCT
app-558	290	13	nishino	nishino	PROPN
app-558	290	14	i.	i.	PROPN
app-558	290	15	a	a	DET
app-558	290	16	gne	gne	PROPN
app-558	290	17	knockout	knockout	PROPN
app-558	290	18	mouse	mouse	NOUN
app-558	290	19	expressing	express	VERB
app-558	290	20	human	human	PROPN
app-558	290	21	gne	gne	PROPN
app-558	290	22	d176v	d176v	PROPN
app-558	290	23	mutation	mutation	NOUN
app-558	290	24	develops	develop	VERB
app-558	290	25	features	feature	NOUN
app-558	290	26	similar	similar	ADJ
app-558	290	27	to	to	ADP
app-558	290	28	distal	distal	ADJ
app-558	290	29	myopathy	myopathy	ADJ
app-558	290	30	with	with	ADP
app-558	290	31	rimmed	rimmed	ADJ
app-558	290	32	vacuoles	vacuole	NOUN
app-558	290	33	or	or	CCONJ
app-558	290	34	hereditary	hereditary	ADJ
app-558	290	35	inclusion	inclusion	NOUN
app-558	290	36	body	body	NOUN
app-558	290	37	myopathy	myopathy	ADJ
app-558	290	38	.	.	PUNCT
app-558	291	1	hum	hum	PROPN
app-558	291	2	mol	mol	ADP
app-558	291	3	genet	genet	NOUN
app-558	291	4	.	.	PUNCT
app-558	292	1	2007;16(22):2669	2007;16(22):2669	NUM
app-558	292	2	-	-	SYM
app-558	292	3	2682	2682	NUM
app-558	292	4	.	.	PUNCT
app-558	293	1	32	32	NUM
app-558	293	2	.	.	PUNCT
app-558	294	1	malicdan	malicdan	PROPN
app-558	294	2	mc	mc	PROPN
app-558	294	3	,	,	PUNCT
app-558	294	4	noguchi	noguchi	PROPN
app-558	294	5	s	s	PROPN
app-558	294	6	,	,	PUNCT
app-558	294	7	hayashi	hayashi	PROPN
app-558	294	8	yk	yk	PROPN
app-558	294	9	,	,	PUNCT
app-558	294	10	nonaka	nonaka	PROPN
app-558	294	11	i	i	PROPN
app-558	294	12	,	,	PUNCT
app-558	294	13	nishino	nishino	PROPN
app-558	294	14	i.	i.	PROPN
app-558	294	15	prophylactic	prophylactic	PROPN
app-558	294	16	treatment	treatment	NOUN
app-558	294	17	with	with	ADP
app-558	294	18	sialic	sialic	ADJ
app-558	294	19	acid	acid	NOUN
app-558	294	20	metabolites	metabolite	NOUN
app-558	294	21	precludes	preclude	VERB
app-558	294	22	the	the	DET
app-558	294	23	development	development	NOUN
app-558	294	24	of	of	ADP
app-558	294	25	the	the	DET
app-558	294	26	myopathic	myopathic	ADJ
app-558	294	27	phenotype	phenotype	NOUN
app-558	294	28	in	in	ADP
app-558	294	29	the	the	DET
app-558	294	30	dmrvhibm	dmrvhibm	PROPN
app-558	294	31	mouse	mouse	PROPN
app-558	294	32	model	model	NOUN
app-558	294	33	.	.	PUNCT
app-558	295	1	nature	nature	PROPN
app-558	295	2	med	me	VERB
app-558	295	3	.	.	PUNCT
app-558	296	1	2009;15(6):690	2009;15(6):690	NUM
app-558	296	2	-	-	SYM
app-558	296	3	695	695	NUM
app-558	296	4	.	.	PUNCT
app-558	297	1	33	33	NUM
app-558	297	2	.	.	PUNCT
app-558	298	1	lau	lau	PROPN
app-558	298	2	ks	ks	PROPN
app-558	298	3	,	,	PUNCT
app-558	298	4	partridge	partridge	NOUN
app-558	298	5	ea	ea	PROPN
app-558	298	6	,	,	PUNCT
app-558	298	7	grigorian	grigorian	PROPN
app-558	298	8	a	a	PRON
app-558	298	9	,	,	PUNCT
app-558	298	10	silvescu	silvescu	PROPN
app-558	298	11	ci	ci	PROPN
app-558	298	12	,	,	PUNCT
app-558	298	13	reinhold	reinhold	PROPN
app-558	298	14	vn	vn	PROPN
app-558	298	15	,	,	PUNCT
app-558	298	16	demetriou	demetriou	PROPN
app-558	298	17	m	m	PROPN
app-558	298	18	,	,	PUNCT
app-558	298	19	dennis	dennis	PROPN
app-558	298	20	jw	jw	PROPN
app-558	298	21	.	.	PROPN
app-558	298	22	complex	complex	PROPN
app-558	298	23	n	n	CCONJ
app-558	298	24	-	-	PUNCT
app-558	298	25	glycan	glycan	NOUN
app-558	298	26	number	number	NOUN
app-558	298	27	and	and	CCONJ
app-558	298	28	degree	degree	NOUN
app-558	298	29	of	of	ADP
app-558	298	30	branching	branch	VERB
app-558	298	31	cooperate	cooperate	NOUN
app-558	298	32	to	to	PART
app-558	298	33	regulate	regulate	VERB
app-558	298	34	cell	cell	NOUN
app-558	298	35	proliferation	proliferation	NOUN
app-558	298	36	and	and	CCONJ
app-558	298	37	differentiation	differentiation	NOUN
app-558	298	38	.	.	PUNCT
app-558	299	1	cell	cell	NOUN
app-558	299	2	.	.	PUNCT
app-558	300	1	2007;129(1):123	2007;129(1):123	NUM
app-558	300	2	-	-	SYM
app-558	300	3	34	34	NUM
app-558	300	4	.	.	PUNCT
app-558	300	5	https://crossmark.crossref.org/dialog/?doi=10.29052/2412-3188.v8.i2.2022.86-95	https://crossmark.crossref.org/dialog/?doi=10.29052/2412-3188.v8.i2.2022.86-95	PUNCT