id	sid	tid	token	lemma	pos
app-717	1	1	editorial	editorial	NOUN
app-717	1	2	for	for	ADP
app-717	1	3	annals	annal	NOUN
app-717	1	4	of	of	ADP
app-717	1	5	psychophysiology	psychophysiology	NOUN
app-717	1	6	volume	volume	NOUN
app-717	1	7	11	11	NUM
app-717	1	8	issue	issue	NOUN
app-717	1	9	1	1	NUM
app-717	1	10	52	52	NUM
app-717	1	11	52	52	NUM
app-717	1	12	-	-	SYM
app-717	1	13	59	59	NUM
app-717	1	14	annals	annal	NOUN
app-717	1	15	of	of	ADP
app-717	1	16	applied	apply	VERB
app-717	1	17	psychophysiology	psychophysiology	NOUN
app-717	1	18	december	december	PROPN
app-717	1	19	2024	2024	NUM
app-717	1	20	volume	volume	NOUN
app-717	1	21	11	11	NUM
app-717	1	22	hormone	hormone	NOUN
app-717	1	23	replacement	replacement	NOUN
app-717	1	24	therapy	therapy	NOUN
app-717	1	25	and	and	CCONJ
app-717	1	26	mood	mood	NOUN
app-717	1	27	disorders	disorder	NOUN
app-717	1	28	during	during	ADP
app-717	1	29	menopause	menopause	NOUN
app-717	1	30	monica	monica	PROPN
app-717	1	31	persson1	persson1	PROPN
app-717	1	32	,	,	PUNCT
app-717	1	33	published	publish	VERB
app-717	1	34	online	online	ADV
app-717	1	35	:	:	PUNCT
app-717	1	36	december	december	PROPN
app-717	1	37	2024	2024	NUM
app-717	2	1	©	©	ADP
app-717	2	2	the	the	DET
app-717	2	3	author(s	author(s	NOUN
app-717	2	4	)	)	PUNCT
app-717	2	5	2024	2024	NUM
app-717	2	6	abstract	abstract	ADJ
app-717	2	7	background	background	NOUN
app-717	2	8	:	:	PUNCT
app-717	2	9	menopause	menopause	NOUN
app-717	2	10	is	be	AUX
app-717	2	11	a	a	DET
app-717	2	12	significant	significant	ADJ
app-717	2	13	transitional	transitional	ADJ
app-717	2	14	phase	phase	NOUN
app-717	2	15	for	for	ADP
app-717	2	16	women	woman	NOUN
app-717	2	17	,	,	PUNCT
app-717	2	18	marked	mark	VERB
app-717	2	19	by	by	ADP
app-717	2	20	hormonal	hormonal	ADJ
app-717	2	21	changes	change	NOUN
app-717	2	22	that	that	PRON
app-717	2	23	profoundly	profoundly	ADV
app-717	2	24	affect	affect	VERB
app-717	2	25	physical	physical	ADJ
app-717	2	26	and	and	CCONJ
app-717	2	27	mental	mental	ADJ
app-717	2	28	health	health	NOUN
app-717	2	29	.	.	PUNCT
app-717	3	1	this	this	DET
app-717	3	2	paper	paper	NOUN
app-717	3	3	examines	examine	VERB
app-717	3	4	the	the	DET
app-717	3	5	intricate	intricate	ADJ
app-717	3	6	relationship	relationship	NOUN
app-717	3	7	between	between	ADP
app-717	3	8	menopause	menopause	NOUN
app-717	3	9	,	,	PUNCT
app-717	3	10	hormonal	hormonal	ADJ
app-717	3	11	fluctuations	fluctuation	NOUN
app-717	3	12	,	,	PUNCT
app-717	3	13	and	and	CCONJ
app-717	3	14	mood	mood	NOUN
app-717	3	15	disorders	disorder	NOUN
app-717	3	16	,	,	PUNCT
app-717	3	17	emphasizing	emphasize	VERB
app-717	3	18	the	the	DET
app-717	3	19	challenges	challenge	NOUN
app-717	3	20	of	of	ADP
app-717	3	21	treatment	treatment	NOUN
app-717	3	22	.	.	PUNCT
app-717	4	1	the	the	DET
app-717	4	2	depletion	depletion	NOUN
app-717	4	3	of	of	ADP
app-717	4	4	ovarian	ovarian	ADJ
app-717	4	5	follicles	follicle	NOUN
app-717	4	6	and	and	CCONJ
app-717	4	7	the	the	DET
app-717	4	8	resulting	result	VERB
app-717	4	9	decline	decline	NOUN
app-717	4	10	in	in	ADP
app-717	4	11	estrogen	estrogen	NOUN
app-717	4	12	,	,	PUNCT
app-717	4	13	progesterone	progesterone	NOUN
app-717	4	14	,	,	PUNCT
app-717	4	15	and	and	CCONJ
app-717	4	16	other	other	ADJ
app-717	4	17	hormones	hormone	NOUN
app-717	4	18	disrupt	disrupt	VERB
app-717	4	19	the	the	DET
app-717	4	20	hypothalamic	hypothalamic	ADJ
app-717	4	21	-	-	PUNCT
app-717	4	22	pituitary	pituitary	ADJ
app-717	4	23	-	-	PUNCT
app-717	4	24	gonadal	gonadal	NOUN
app-717	4	25	axis	axis	NOUN
app-717	4	26	and	and	CCONJ
app-717	4	27	neurotransmitter	neurotransmitter	NOUN
app-717	4	28	pathways	pathway	NOUN
app-717	4	29	,	,	PUNCT
app-717	4	30	leading	lead	VERB
app-717	4	31	to	to	ADP
app-717	4	32	increased	increase	VERB
app-717	4	33	rates	rate	NOUN
app-717	4	34	of	of	ADP
app-717	4	35	depression	depression	NOUN
app-717	4	36	,	,	PUNCT
app-717	4	37	anxiety	anxiety	NOUN
app-717	4	38	,	,	PUNCT
app-717	4	39	and	and	CCONJ
app-717	4	40	other	other	ADJ
app-717	4	41	mood	mood	NOUN
app-717	4	42	disorders	disorder	NOUN
app-717	4	43	in	in	ADP
app-717	4	44	middle	middle	ADJ
app-717	4	45	-	-	PUNCT
app-717	4	46	aged	aged	ADJ
app-717	4	47	women	woman	NOUN
app-717	4	48	.	.	PUNCT
app-717	5	1	conventional	conventional	ADJ
app-717	5	2	treatments	treatment	NOUN
app-717	5	3	,	,	PUNCT
app-717	5	4	such	such	ADJ
app-717	5	5	as	as	ADP
app-717	5	6	selective	selective	ADJ
app-717	5	7	serotonin	serotonin	NOUN
app-717	5	8	reuptake	reuptake	NOUN
app-717	5	9	inhibitors	inhibitor	NOUN
app-717	5	10	(	(	PUNCT
app-717	5	11	ssris	ssris	PROPN
app-717	5	12	)	)	PUNCT
app-717	5	13	,	,	PUNCT
app-717	5	14	are	be	AUX
app-717	5	15	often	often	ADV
app-717	5	16	less	less	ADV
app-717	5	17	effective	effective	ADJ
app-717	5	18	for	for	ADP
app-717	5	19	menopausal	menopausal	ADJ
app-717	5	20	-	-	PUNCT
app-717	5	21	related	relate	VERB
app-717	5	22	mood	mood	NOUN
app-717	5	23	disorders	disorder	NOUN
app-717	5	24	,	,	PUNCT
app-717	5	25	underscoring	underscore	VERB
app-717	5	26	the	the	DET
app-717	5	27	need	need	NOUN
app-717	5	28	for	for	ADP
app-717	5	29	alternative	alternative	ADJ
app-717	5	30	approaches	approach	NOUN
app-717	5	31	.	.	PUNCT
app-717	6	1	methodology	methodology	NOUN
app-717	6	2	:	:	PUNCT
app-717	6	3	a	a	DET
app-717	6	4	targeted	target	VERB
app-717	6	5	review	review	NOUN
app-717	6	6	of	of	ADP
app-717	6	7	current	current	ADJ
app-717	6	8	literature	literature	NOUN
app-717	6	9	explores	explore	NOUN
app-717	6	10	conventional	conventional	ADJ
app-717	6	11	and	and	CCONJ
app-717	6	12	alternative	alternative	ADJ
app-717	6	13	treatment	treatment	NOUN
app-717	6	14	approaches	approach	NOUN
app-717	6	15	for	for	ADP
app-717	6	16	menopausal	menopausal	ADJ
app-717	6	17	mood	mood	NOUN
app-717	6	18	disorders	disorder	NOUN
app-717	6	19	.	.	PUNCT
app-717	7	1	this	this	PRON
app-717	7	2	includes	include	VERB
app-717	7	3	a	a	DET
app-717	7	4	review	review	NOUN
app-717	7	5	of	of	ADP
app-717	7	6	pharmacological	pharmacological	ADJ
app-717	7	7	therapies	therapy	NOUN
app-717	7	8	,	,	PUNCT
app-717	7	9	such	such	ADJ
app-717	7	10	as	as	ADP
app-717	7	11	selective	selective	ADJ
app-717	7	12	serotonin	serotonin	NOUN
app-717	7	13	reuptake	reuptake	NOUN
app-717	7	14	inhibitors	inhibitor	NOUN
app-717	7	15	(	(	PUNCT
app-717	7	16	ssris	ssris	NOUN
app-717	7	17	)	)	PUNCT
app-717	7	18	,	,	PUNCT
app-717	7	19	and	and	CCONJ
app-717	7	20	the	the	DET
app-717	7	21	potential	potential	ADJ
app-717	7	22	efficacy	efficacy	NOUN
app-717	7	23	of	of	ADP
app-717	7	24	hormone	hormone	NOUN
app-717	7	25	replacement	replacement	NOUN
app-717	7	26	therapy	therapy	NOUN
app-717	7	27	(	(	PUNCT
app-717	7	28	hrt	hrt	PROPN
app-717	7	29	)	)	PUNCT
app-717	7	30	in	in	ADP
app-717	7	31	mitigating	mitigate	VERB
app-717	7	32	mood	mood	NOUN
app-717	7	33	-	-	PUNCT
app-717	7	34	related	relate	VERB
app-717	7	35	symptoms	symptom	NOUN
app-717	7	36	.	.	PUNCT
app-717	8	1	results	result	NOUN
app-717	8	2	:	:	PUNCT
app-717	8	3	conventional	conventional	ADJ
app-717	8	4	treatments	treatment	NOUN
app-717	8	5	like	like	ADP
app-717	8	6	ssris	ssris	PROPN
app-717	8	7	are	be	AUX
app-717	8	8	often	often	ADV
app-717	8	9	less	less	ADV
app-717	8	10	effective	effective	ADJ
app-717	8	11	for	for	ADP
app-717	8	12	menopausal	menopausal	ADJ
app-717	8	13	mood	mood	NOUN
app-717	8	14	disorders	disorder	NOUN
app-717	8	15	,	,	PUNCT
app-717	8	16	underscoring	underscore	VERB
app-717	8	17	the	the	DET
app-717	8	18	need	need	NOUN
app-717	8	19	for	for	ADP
app-717	8	20	alternative	alternative	ADJ
app-717	8	21	approaches	approach	NOUN
app-717	8	22	.	.	PUNCT
app-717	9	1	hrt	hrt	PROPN
app-717	9	2	emerges	emerge	VERB
app-717	9	3	as	as	ADP
app-717	9	4	a	a	DET
app-717	9	5	viable	viable	ADJ
app-717	9	6	option	option	NOUN
app-717	9	7	,	,	PUNCT
app-717	9	8	offering	offer	VERB
app-717	9	9	symptom	symptom	NOUN
app-717	9	10	relief	relief	NOUN
app-717	9	11	from	from	ADP
app-717	9	12	vasomotor	vasomotor	NOUN
app-717	9	13	and	and	CCONJ
app-717	9	14	genitourinary	genitourinary	ADJ
app-717	9	15	syndromes	syndrome	NOUN
app-717	9	16	,	,	PUNCT
app-717	9	17	improved	improve	VERB
app-717	9	18	cardiovascular	cardiovascular	ADJ
app-717	9	19	and	and	CCONJ
app-717	9	20	bone	bone	NOUN
app-717	9	21	health	health	NOUN
app-717	9	22	,	,	PUNCT
app-717	9	23	and	and	CCONJ
app-717	9	24	potential	potential	ADJ
app-717	9	25	mitigation	mitigation	NOUN
app-717	9	26	of	of	ADP
app-717	9	27	mood	mood	NOUN
app-717	9	28	disorders	disorder	NOUN
app-717	9	29	.	.	PUNCT
app-717	10	1	however	however	ADV
app-717	10	2	,	,	PUNCT
app-717	10	3	the	the	DET
app-717	10	4	controversial	controversial	ADJ
app-717	10	5	results	result	NOUN
app-717	10	6	of	of	ADP
app-717	10	7	the	the	DET
app-717	10	8	2002	2002	NUM
app-717	10	9	women	woman	NOUN
app-717	10	10	’s	’s	PART
app-717	10	11	health	health	NOUN
app-717	10	12	initiative	initiative	NOUN
app-717	10	13	(	(	PUNCT
app-717	10	14	whi	whi	NOUN
app-717	10	15	)	)	PUNCT
app-717	10	16	study	study	NOUN
app-717	10	17	raised	raise	VERB
app-717	10	18	concerns	concern	NOUN
app-717	10	19	about	about	ADP
app-717	10	20	risks	risk	NOUN
app-717	10	21	,	,	PUNCT
app-717	10	22	resulting	result	VERB
app-717	10	23	in	in	ADP
app-717	10	24	reduced	reduced	ADJ
app-717	10	25	usage	usage	NOUN
app-717	10	26	.	.	PUNCT
app-717	11	1	recent	recent	ADJ
app-717	11	2	studies	study	NOUN
app-717	11	3	support	support	VERB
app-717	11	4	the	the	DET
app-717	11	5	“	"	PUNCT
app-717	11	6	critical	critical	ADJ
app-717	11	7	window	window	NOUN
app-717	11	8	”	"	PUNCT
app-717	11	9	hypothesis	hypothesis	NOUN
app-717	11	10	,	,	PUNCT
app-717	11	11	suggesting	suggest	VERB
app-717	11	12	that	that	SCONJ
app-717	11	13	initiating	initiate	VERB
app-717	11	14	hrt	hrt	PRON
app-717	11	15	early	early	ADV
app-717	11	16	in	in	ADP
app-717	11	17	menopause	menopause	NOUN
app-717	11	18	enhances	enhance	VERB
app-717	11	19	safety	safety	NOUN
app-717	11	20	and	and	CCONJ
app-717	11	21	efficacy	efficacy	NOUN
app-717	11	22	.	.	PUNCT
app-717	12	1	conclusion	conclusion	NOUN
app-717	12	2	:	:	PUNCT
app-717	12	3	this	this	DET
app-717	12	4	paper	paper	NOUN
app-717	12	5	highlights	highlight	VERB
app-717	12	6	the	the	DET
app-717	12	7	importance	importance	NOUN
app-717	12	8	of	of	ADP
app-717	12	9	personalized	personalized	ADJ
app-717	12	10	and	and	CCONJ
app-717	12	11	integrative	integrative	ADJ
app-717	12	12	strategies	strategy	NOUN
app-717	12	13	for	for	ADP
app-717	12	14	managing	manage	VERB
app-717	12	15	menopause	menopause	NOUN
app-717	12	16	and	and	CCONJ
app-717	12	17	mood	mood	NOUN
app-717	12	18	disorders	disorder	NOUN
app-717	12	19	.	.	PUNCT
app-717	13	1	although	although	SCONJ
app-717	13	2	hrt	hrt	PROPN
app-717	13	3	shows	show	VERB
app-717	13	4	promise	promise	VERB
app-717	13	5	,	,	PUNCT
app-717	13	6	further	further	ADJ
app-717	13	7	research	research	NOUN
app-717	13	8	is	be	AUX
app-717	13	9	essential	essential	ADJ
app-717	13	10	to	to	PART
app-717	13	11	clarify	clarify	VERB
app-717	13	12	its	its	PRON
app-717	13	13	influence	influence	NOUN
app-717	13	14	on	on	ADP
app-717	13	15	inflammatory	inflammatory	ADJ
app-717	13	16	pathways	pathway	NOUN
app-717	13	17	and	and	CCONJ
app-717	13	18	neuroinflammatory	neuroinflammatory	ADJ
app-717	13	19	mechanisms	mechanism	NOUN
app-717	13	20	.	.	PUNCT
app-717	14	1	understanding	understand	VERB
app-717	14	2	the	the	DET
app-717	14	3	long	long	ADJ
app-717	14	4	-	-	PUNCT
app-717	14	5	term	term	NOUN
app-717	14	6	effects	effect	NOUN
app-717	14	7	of	of	ADP
app-717	14	8	hrt	hrt	PROPN
app-717	14	9	and	and	CCONJ
app-717	14	10	addressing	address	VERB
app-717	14	11	the	the	DET
app-717	14	12	unique	unique	ADJ
app-717	14	13	hormonal	hormonal	ADJ
app-717	14	14	and	and	CCONJ
app-717	14	15	neurobiological	neurobiological	ADJ
app-717	14	16	dynamics	dynamic	NOUN
app-717	14	17	of	of	ADP
app-717	14	18	menopausal	menopausal	ADJ
app-717	14	19	women	woman	NOUN
app-717	14	20	are	be	AUX
app-717	14	21	critical	critical	ADJ
app-717	14	22	for	for	ADP
app-717	14	23	developing	develop	VERB
app-717	14	24	targeted	target	VERB
app-717	14	25	interventions	intervention	NOUN
app-717	14	26	and	and	CCONJ
app-717	14	27	improving	improve	VERB
app-717	14	28	outcomes	outcome	NOUN
app-717	14	29	for	for	ADP
app-717	14	30	this	this	DET
app-717	14	31	underserved	underserved	ADJ
app-717	14	32	demographic	demographic	ADJ
app-717	14	33	.	.	PUNCT
app-717	15	1	keywords	keyword	NOUN
app-717	15	2	:	:	PUNCT
app-717	15	3	estrogen	estrogen	NOUN
app-717	15	4	,	,	PUNCT
app-717	15	5	progesterone	progesterone	NOUN
app-717	15	6	,	,	PUNCT
app-717	15	7	reproductive	reproductive	ADJ
app-717	15	8	hormones	hormone	NOUN
app-717	15	9	,	,	PUNCT
app-717	15	10	hormone	hormone	NOUN
app-717	15	11	replacement	replacement	NOUN
app-717	15	12	therapy	therapy	NOUN
app-717	15	13	,	,	PUNCT
app-717	15	14	mood	mood	NOUN
app-717	15	15	disorders	disorder	NOUN
app-717	15	16	,	,	PUNCT
app-717	15	17	depression	depression	NOUN
app-717	15	18	,	,	PUNCT
app-717	15	19	anxiety	anxiety	NOUN
app-717	15	20	.	.	PUNCT
app-717	16	1	1	1	X
app-717	16	2	.	.	X
app-717	16	3	monica	monica	PROPN
app-717	16	4	persson	persson	PROPN
app-717	16	5	mpersson@saybrook.edu	mpersson@saybrook.edu	PROPN
app-717	17	1	saybrook	saybrook	PROPN
app-717	17	2	university	university	PROPN
app-717	17	3	,	,	PUNCT
app-717	17	4	pasadena	pasadena	PROPN
app-717	17	5	,	,	PUNCT
app-717	17	6	ca	ca	PROPN
app-717	17	7	,	,	PUNCT
app-717	17	8	usa	usa	PROPN
app-717	17	9	mailto:mpersson@saybrook.edu	mailto:mpersson@saybrook.edu	PROPN
app-717	17	10	53	53	NUM
app-717	17	11	hormone	hormone	NOUN
app-717	17	12	replacement	replacement	NOUN
app-717	17	13	therapy	therapy	NOUN
app-717	17	14	and	and	CCONJ
app-717	17	15	mood	mood	NOUN
app-717	17	16	disorders	disorder	NOUN
app-717	17	17	during	during	ADP
app-717	17	18	menopause	menopause	NOUN
app-717	17	19	all	all	DET
app-717	17	20	human	human	ADJ
app-717	17	21	females	female	NOUN
app-717	17	22	with	with	ADP
app-717	17	23	ovaries	ovary	NOUN
app-717	17	24	who	who	PRON
app-717	17	25	reach	reach	VERB
app-717	17	26	puberty	puberty	NOUN
app-717	17	27	will	will	AUX
app-717	17	28	ultimately	ultimately	ADV
app-717	17	29	experience	experience	VERB
app-717	17	30	menopause	menopause	NOUN
app-717	17	31	,	,	PUNCT
app-717	17	32	provided	provide	VERB
app-717	17	33	they	they	PRON
app-717	17	34	live	live	VERB
app-717	17	35	long	long	ADV
app-717	17	36	enough	enough	ADV
app-717	17	37	.	.	PUNCT
app-717	18	1	menopause	menopause	NOUN
app-717	18	2	consists	consist	VERB
app-717	18	3	of	of	ADP
app-717	18	4	three	three	NUM
app-717	18	5	main	main	ADJ
app-717	18	6	stages	stage	NOUN
app-717	18	7	:	:	PUNCT
app-717	18	8	perimenopause	perimenopause	NOUN
app-717	18	9	,	,	PUNCT
app-717	18	10	menopause	menopause	NOUN
app-717	18	11	,	,	PUNCT
app-717	18	12	and	and	CCONJ
app-717	18	13	post	post	NOUN
app-717	18	14	menopause	menopause	NOUN
app-717	18	15	,	,	PUNCT
app-717	18	16	generally	generally	ADV
app-717	18	17	occurring	occur	VERB
app-717	18	18	between	between	ADP
app-717	18	19	the	the	DET
app-717	18	20	ages	age	NOUN
app-717	18	21	of	of	ADP
app-717	18	22	40	40	NUM
app-717	18	23	and	and	CCONJ
app-717	18	24	60	60	NUM
app-717	18	25	.	.	PUNCT
app-717	19	1	at	at	ADP
app-717	19	2	this	this	DET
app-717	19	3	stage	stage	NOUN
app-717	19	4	,	,	PUNCT
app-717	19	5	the	the	DET
app-717	19	6	ovaries	ovary	NOUN
app-717	19	7	begin	begin	VERB
app-717	19	8	to	to	ADP
app-717	19	9	atrophy	atrophy	NOUN
app-717	19	10	,	,	PUNCT
app-717	19	11	decreasing	decrease	VERB
app-717	19	12	the	the	DET
app-717	19	13	production	production	NOUN
app-717	19	14	of	of	ADP
app-717	19	15	the	the	DET
app-717	19	16	main	main	ADJ
app-717	19	17	hormones	hormone	NOUN
app-717	19	18	that	that	PRON
app-717	19	19	regulate	regulate	VERB
app-717	19	20	the	the	DET
app-717	19	21	menstrual	menstrual	ADJ
app-717	19	22	cycle	cycle	NOUN
app-717	19	23	:	:	PUNCT
app-717	19	24	estrogen	estrogen	NOUN
app-717	19	25	and	and	CCONJ
app-717	19	26	progesterone	progesterone	NOUN
app-717	19	27	.	.	PUNCT
app-717	20	1	most	most	ADJ
app-717	20	2	women	woman	NOUN
app-717	20	3	experience	experience	VERB
app-717	20	4	vasomotor	vasomotor	NOUN
app-717	20	5	(	(	PUNCT
app-717	20	6	hot	hot	ADJ
app-717	20	7	flashes	flash	NOUN
app-717	20	8	,	,	PUNCT
app-717	20	9	excessive	excessive	ADJ
app-717	20	10	sweating	sweating	NOUN
app-717	20	11	,	,	PUNCT
app-717	20	12	sleep	sleep	NOUN
app-717	20	13	disturbance	disturbance	NOUN
app-717	20	14	)	)	PUNCT
app-717	20	15	and	and	CCONJ
app-717	20	16	genitourinary	genitourinary	ADJ
app-717	20	17	(	(	PUNCT
app-717	20	18	vaginal	vaginal	ADJ
app-717	20	19	dryness	dryness	NOUN
app-717	20	20	,	,	PUNCT
app-717	20	21	pain	pain	NOUN
app-717	20	22	during	during	ADP
app-717	20	23	intercourse	intercourse	NOUN
app-717	20	24	,	,	PUNCT
app-717	20	25	urinary	urinary	ADJ
app-717	20	26	incontinence	incontinence	NOUN
app-717	20	27	,	,	PUNCT
app-717	20	28	decreased	decrease	VERB
app-717	20	29	libido	libido	NOUN
app-717	20	30	)	)	PUNCT
app-717	20	31	symptoms	symptom	NOUN
app-717	20	32	during	during	ADP
app-717	20	33	this	this	DET
app-717	20	34	period	period	NOUN
app-717	20	35	(	(	PUNCT
app-717	20	36	jin	jin	NOUN
app-717	20	37	,	,	PUNCT
app-717	20	38	2017	2017	NUM
app-717	20	39	)	)	PUNCT
app-717	20	40	.	.	PUNCT
app-717	21	1	middle	middle	ADJ
app-717	21	2	-	-	PUNCT
app-717	21	3	aged	aged	ADJ
app-717	21	4	women	woman	NOUN
app-717	21	5	also	also	ADV
app-717	21	6	experience	experience	VERB
app-717	21	7	significant	significant	ADJ
app-717	21	8	increases	increase	NOUN
app-717	21	9	in	in	ADP
app-717	21	10	depression	depression	NOUN
app-717	21	11	,	,	PUNCT
app-717	21	12	anxiety	anxiety	NOUN
app-717	21	13	,	,	PUNCT
app-717	21	14	post	post	ADJ
app-717	21	15	-	-	ADJ
app-717	21	16	traumatic	traumatic	ADJ
app-717	21	17	stress	stress	NOUN
app-717	21	18	disorder	disorder	NOUN
app-717	21	19	,	,	PUNCT
app-717	21	20	and	and	CCONJ
app-717	21	21	substance	substance	NOUN
app-717	21	22	abuse	abuse	NOUN
app-717	21	23	compared	compare	VERB
app-717	21	24	to	to	ADP
app-717	21	25	other	other	ADJ
app-717	21	26	age	age	NOUN
app-717	21	27	groups	group	NOUN
app-717	21	28	.	.	PUNCT
app-717	22	1	as	as	ADP
app-717	22	2	a	a	DET
app-717	22	3	demographic	demographic	ADJ
app-717	22	4	cohort	cohort	NOUN
app-717	22	5	,	,	PUNCT
app-717	22	6	women	woman	NOUN
app-717	22	7	in	in	ADP
app-717	22	8	this	this	DET
app-717	22	9	age	age	NOUN
app-717	22	10	range	range	NOUN
app-717	22	11	have	have	VERB
app-717	22	12	a	a	DET
app-717	22	13	high	high	ADJ
app-717	22	14	suicide	suicide	NOUN
app-717	22	15	rate	rate	NOUN
app-717	22	16	(	(	PUNCT
app-717	22	17	maki	maki	NOUN
app-717	22	18	et	et	PROPN
app-717	22	19	al	al	PROPN
app-717	22	20	.	.	PROPN
app-717	22	21	,	,	PUNCT
app-717	22	22	2019	2019	NUM
app-717	22	23	,	,	PUNCT
app-717	22	24	as	as	SCONJ
app-717	22	25	cited	cite	VERB
app-717	22	26	by	by	ADP
app-717	22	27	kulkarni	kulkarni	PROPN
app-717	22	28	et	et	PROPN
app-717	22	29	al	al	PROPN
app-717	22	30	.	.	PROPN
app-717	22	31	,	,	PUNCT
app-717	22	32	2024	2024	NUM
app-717	22	33	)	)	PUNCT
app-717	22	34	.	.	PUNCT
app-717	23	1	cultural	cultural	ADJ
app-717	23	2	,	,	PUNCT
app-717	23	3	genetic	genetic	ADJ
app-717	23	4	,	,	PUNCT
app-717	23	5	and	and	CCONJ
app-717	23	6	environmental	environmental	ADJ
app-717	23	7	factors	factor	NOUN
app-717	23	8	influence	influence	VERB
app-717	23	9	the	the	DET
app-717	23	10	menopause	menopause	NOUN
app-717	23	11	journey	journey	NOUN
app-717	23	12	and	and	CCONJ
app-717	23	13	subsequent	subsequent	ADJ
app-717	23	14	treatment	treatment	NOUN
app-717	23	15	efficacy	efficacy	NOUN
app-717	23	16	.	.	PUNCT
app-717	24	1	during	during	ADP
app-717	24	2	the	the	DET
app-717	24	3	feminist	feminist	PROPN
app-717	24	4	movement	movement	NOUN
app-717	24	5	of	of	ADP
app-717	24	6	the	the	DET
app-717	24	7	1960s	1960	NOUN
app-717	24	8	,	,	PUNCT
app-717	24	9	there	there	PRON
app-717	24	10	was	be	VERB
app-717	24	11	a	a	DET
app-717	24	12	significant	significant	ADJ
app-717	24	13	shift	shift	NOUN
app-717	24	14	in	in	ADP
app-717	24	15	the	the	DET
app-717	24	16	promotion	promotion	NOUN
app-717	24	17	of	of	ADP
app-717	24	18	menopausal	menopausal	ADJ
app-717	24	19	therapy	therapy	NOUN
app-717	24	20	,	,	PUNCT
app-717	24	21	especially	especially	ADV
app-717	24	22	in	in	ADP
app-717	24	23	european	european	ADJ
app-717	24	24	countries	country	NOUN
app-717	24	25	,	,	PUNCT
app-717	24	26	with	with	ADP
app-717	24	27	the	the	DET
app-717	24	28	concept	concept	NOUN
app-717	24	29	of	of	ADP
app-717	24	30	"	"	PUNCT
app-717	24	31	feminine	feminine	ADJ
app-717	24	32	forever	forever	ADV
app-717	24	33	"	"	PUNCT
app-717	24	34	(	(	PUNCT
app-717	24	35	wilson	wilson	PROPN
app-717	24	36	,	,	PUNCT
app-717	24	37	1968	1968	NUM
app-717	24	38	)	)	PUNCT
app-717	24	39	.	.	PUNCT
app-717	25	1	a	a	DET
app-717	25	2	book	book	NOUN
app-717	25	3	by	by	ADP
app-717	25	4	the	the	DET
app-717	25	5	same	same	ADJ
app-717	25	6	title	title	NOUN
app-717	25	7	became	become	VERB
app-717	25	8	a	a	DET
app-717	25	9	bestseller	bestseller	NOUN
app-717	25	10	,	,	PUNCT
app-717	25	11	claiming	claim	VERB
app-717	25	12	that	that	SCONJ
app-717	25	13	“	"	PUNCT
app-717	25	14	menopause	menopause	NOUN
app-717	25	15	is	be	AUX
app-717	25	16	a	a	DET
app-717	25	17	hormone	hormone	NOUN
app-717	25	18	deficiency	deficiency	NOUN
app-717	25	19	disease	disease	NOUN
app-717	25	20	,	,	PUNCT
app-717	25	21	curable	curable	ADJ
app-717	25	22	and	and	CCONJ
app-717	25	23	totally	totally	ADV
app-717	25	24	preventable	preventable	ADJ
app-717	25	25	,	,	PUNCT
app-717	25	26	just	just	ADV
app-717	25	27	take	take	VERB
app-717	25	28	estrogen	estrogen	NOUN
app-717	25	29	”	"	PUNCT
app-717	25	30	(	(	PUNCT
app-717	25	31	wilson	wilson	PROPN
app-717	25	32	,	,	PUNCT
app-717	25	33	1968	1968	NUM
app-717	25	34	,	,	PUNCT
app-717	25	35	as	as	SCONJ
app-717	25	36	cited	cite	VERB
app-717	25	37	in	in	ADP
app-717	25	38	cagnacci	cagnacci	PROPN
app-717	25	39	&	&	CCONJ
app-717	25	40	venier	veni	ADJ
app-717	25	41	,	,	PUNCT
app-717	25	42	2019	2019	NUM
app-717	25	43	,	,	PUNCT
app-717	25	44	p.	p.	NOUN
app-717	25	45	602	602	NUM
app-717	25	46	)	)	PUNCT
app-717	25	47	.	.	PUNCT
app-717	26	1	since	since	SCONJ
app-717	26	2	that	that	DET
app-717	26	3	time	time	NOUN
app-717	26	4	,	,	PUNCT
app-717	26	5	women	woman	NOUN
app-717	26	6	have	have	AUX
app-717	26	7	had	have	VERB
app-717	26	8	a	a	DET
app-717	26	9	complex	complex	ADJ
app-717	26	10	relationship	relationship	NOUN
app-717	26	11	with	with	ADP
app-717	26	12	hormone	hormone	NOUN
app-717	26	13	replacement	replacement	NOUN
app-717	26	14	,	,	PUNCT
app-717	26	15	alternately	alternately	ADV
app-717	26	16	viewing	view	VERB
app-717	26	17	it	it	PRON
app-717	26	18	as	as	ADP
app-717	26	19	a	a	DET
app-717	26	20	panacea	panacea	NOUN
app-717	26	21	or	or	CCONJ
app-717	26	22	risk	risk	VERB
app-717	26	23	too	too	ADV
app-717	26	24	hazardous	hazardous	ADJ
app-717	26	25	to	to	PART
app-717	26	26	employ	employ	VERB
app-717	26	27	.	.	PUNCT
app-717	27	1	menopause	menopause	NOUN
app-717	27	2	is	be	AUX
app-717	27	3	a	a	DET
app-717	27	4	complex	complex	ADJ
app-717	27	5	biological	biological	ADJ
app-717	27	6	process	process	NOUN
app-717	27	7	characterized	characterize	VERB
app-717	27	8	by	by	ADP
app-717	27	9	hormonal	hormonal	ADJ
app-717	27	10	changes	change	NOUN
app-717	27	11	that	that	PRON
app-717	27	12	can	can	AUX
app-717	27	13	significantly	significantly	ADV
app-717	27	14	impact	impact	VERB
app-717	27	15	mental	mental	ADJ
app-717	27	16	health	health	NOUN
app-717	27	17	,	,	PUNCT
app-717	27	18	creating	create	VERB
app-717	27	19	challenges	challenge	NOUN
app-717	27	20	for	for	ADP
app-717	27	21	effective	effective	ADJ
app-717	27	22	treatment	treatment	NOUN
app-717	27	23	.	.	PUNCT
app-717	28	1	pre	pre	ADJ
app-717	28	2	-	-	ADJ
app-717	28	3	menopausal	menopausal	ADJ
app-717	28	4	women	woman	NOUN
app-717	28	5	without	without	ADP
app-717	28	6	a	a	DET
app-717	28	7	history	history	NOUN
app-717	28	8	of	of	ADP
app-717	28	9	mood	mood	NOUN
app-717	28	10	disorders	disorder	NOUN
app-717	28	11	are	be	AUX
app-717	28	12	nearly	nearly	ADV
app-717	28	13	twice	twice	ADV
app-717	28	14	as	as	ADV
app-717	28	15	likely	likely	ADJ
app-717	28	16	to	to	PART
app-717	28	17	develop	develop	VERB
app-717	28	18	symptoms	symptom	NOUN
app-717	28	19	of	of	ADP
app-717	28	20	anxiety	anxiety	NOUN
app-717	28	21	and	and	CCONJ
app-717	28	22	depression	depression	NOUN
app-717	28	23	during	during	ADP
app-717	28	24	menopause	menopause	NOUN
app-717	28	25	compared	compare	VERB
app-717	28	26	to	to	ADP
app-717	28	27	those	those	PRON
app-717	28	28	with	with	ADP
app-717	28	29	no	no	DET
app-717	28	30	prior	prior	ADJ
app-717	28	31	mood	mood	NOUN
app-717	28	32	disorder	disorder	NOUN
app-717	28	33	history	history	NOUN
app-717	28	34	(	(	PUNCT
app-717	28	35	cohen	cohen	PROPN
app-717	28	36	et	et	PROPN
app-717	28	37	al	al	PROPN
app-717	28	38	.	.	PROPN
app-717	28	39	,	,	PUNCT
app-717	28	40	2006	2006	NUM
app-717	28	41	,	,	PUNCT
app-717	28	42	as	as	SCONJ
app-717	28	43	cited	cite	VERB
app-717	28	44	in	in	ADP
app-717	28	45	alblooshi	alblooshi	PROPN
app-717	28	46	et	et	PROPN
app-717	28	47	al	al	PROPN
app-717	28	48	.	.	PROPN
app-717	28	49	,	,	PUNCT
app-717	28	50	2023	2023	NUM
app-717	28	51	)	)	PUNCT
app-717	28	52	.	.	PUNCT
app-717	29	1	as	as	SCONJ
app-717	29	2	ovarian	ovarian	ADJ
app-717	29	3	follicles	follicle	VERB
app-717	29	4	deplete	deplete	NOUN
app-717	29	5	,	,	PUNCT
app-717	29	6	ovarian	ovarian	ADJ
app-717	29	7	function	function	NOUN
app-717	29	8	declines	decline	VERB
app-717	29	9	,	,	PUNCT
app-717	29	10	leading	lead	VERB
app-717	29	11	to	to	ADP
app-717	29	12	a	a	DET
app-717	29	13	reduction	reduction	NOUN
app-717	29	14	in	in	ADP
app-717	29	15	mood	mood	NOUN
app-717	29	16	-	-	PUNCT
app-717	29	17	regulating	regulate	VERB
app-717	29	18	hormones	hormone	NOUN
app-717	29	19	.	.	PUNCT
app-717	30	1	this	this	DET
app-717	30	2	shift	shift	NOUN
app-717	30	3	disrupts	disrupt	VERB
app-717	30	4	the	the	DET
app-717	30	5	hypothalamic	hypothalamic	ADJ
app-717	30	6	-	-	PUNCT
app-717	30	7	pituitary	pituitary	ADJ
app-717	30	8	-	-	PUNCT
app-717	30	9	gonadal	gonadal	NOUN
app-717	30	10	axis	axis	NOUN
app-717	30	11	,	,	PUNCT
app-717	30	12	influencing	influence	VERB
app-717	30	13	mood	mood	NOUN
app-717	30	14	regulation	regulation	NOUN
app-717	30	15	and	and	CCONJ
app-717	30	16	stress	stress	NOUN
app-717	30	17	responses	response	NOUN
app-717	30	18	.	.	PUNCT
app-717	31	1	life	life	NOUN
app-717	31	2	stages	stage	VERB
app-717	31	3	with	with	ADP
app-717	31	4	low	low	ADJ
app-717	31	5	estrogen	estrogen	NOUN
app-717	31	6	levels	level	NOUN
app-717	31	7	(	(	PUNCT
app-717	31	8	premenstrual	premenstrual	ADJ
app-717	31	9	,	,	PUNCT
app-717	31	10	postpartum	postpartum	NOUN
app-717	31	11	,	,	PUNCT
app-717	31	12	menopause	menopause	NOUN
app-717	31	13	)	)	PUNCT
app-717	31	14	are	be	AUX
app-717	31	15	linked	link	VERB
app-717	31	16	to	to	ADP
app-717	31	17	increased	increase	VERB
app-717	31	18	depressive	depressive	ADJ
app-717	31	19	symptoms	symptom	NOUN
app-717	31	20	.	.	PUNCT
app-717	32	1	additionally	additionally	ADV
app-717	32	2	,	,	PUNCT
app-717	32	3	between	between	ADP
app-717	32	4	15	15	NUM
app-717	32	5	%	%	NOUN
app-717	32	6	to	to	PART
app-717	32	7	50	50	NUM
app-717	32	8	%	%	NOUN
app-717	32	9	of	of	ADP
app-717	32	10	women	woman	NOUN
app-717	32	11	report	report	VERB
app-717	32	12	experiencing	experience	VERB
app-717	32	13	depression	depression	NOUN
app-717	32	14	during	during	ADP
app-717	32	15	the	the	DET
app-717	32	16	menopause	menopause	NOUN
app-717	32	17	transition	transition	NOUN
app-717	32	18	(	(	PUNCT
app-717	32	19	toffol	toffol	NOUN
app-717	32	20	et	et	NOUN
app-717	32	21	al	al	PROPN
app-717	32	22	.	.	PROPN
app-717	32	23	,	,	PUNCT
app-717	32	24	2015	2015	NUM
app-717	32	25	,	,	PUNCT
app-717	32	26	as	as	SCONJ
app-717	32	27	cited	cite	VERB
app-717	32	28	by	by	ADP
app-717	32	29	wieczorek	wieczorek	PROPN
app-717	32	30	et	et	PROPN
app-717	32	31	al	al	PROPN
app-717	32	32	.	.	PROPN
app-717	32	33	,	,	PUNCT
app-717	32	34	2023	2023	NUM
app-717	32	35	)	)	PUNCT
app-717	32	36	.	.	PUNCT
app-717	33	1	fluctuations	fluctuation	NOUN
app-717	33	2	in	in	ADP
app-717	33	3	estrogen	estrogen	NOUN
app-717	33	4	,	,	PUNCT
app-717	33	5	progesterone	progesterone	NOUN
app-717	33	6	,	,	PUNCT
app-717	33	7	testosterone	testosterone	NOUN
app-717	33	8	,	,	PUNCT
app-717	33	9	cortisol	cortisol	NOUN
app-717	33	10	,	,	PUNCT
app-717	33	11	triiodothyronine	triiodothyronine	NOUN
app-717	33	12	(	(	PUNCT
app-717	33	13	t3	t3	PROPN
app-717	33	14	)	)	PUNCT
app-717	33	15	,	,	PUNCT
app-717	33	16	thyroxine	thyroxine	NOUN
app-717	33	17	(	(	PUNCT
app-717	33	18	t4	t4	PROPN
app-717	33	19	)	)	PUNCT
app-717	33	20	,	,	PUNCT
app-717	33	21	dehydroepiandrosterone	dehydroepiandrosterone	NOUN
app-717	33	22	,	,	PUNCT
app-717	33	23	follicle	follicle	NOUN
app-717	33	24	-	-	PUNCT
app-717	33	25	stimulating	stimulate	VERB
app-717	33	26	hormone	hormone	NOUN
app-717	33	27	(	(	PUNCT
app-717	33	28	fsh	fsh	NOUN
app-717	33	29	)	)	PUNCT
app-717	33	30	,	,	PUNCT
app-717	33	31	and	and	CCONJ
app-717	33	32	luteinizing	luteinize	VERB
app-717	33	33	hormone	hormone	NOUN
app-717	33	34	(	(	PUNCT
app-717	33	35	lh	lh	PROPN
app-717	33	36	)	)	PUNCT
app-717	33	37	affect	affect	VERB
app-717	33	38	multiple	multiple	ADJ
app-717	33	39	systems	system	NOUN
app-717	33	40	,	,	PUNCT
app-717	33	41	with	with	ADP
app-717	33	42	estrogen	estrogen	NOUN
app-717	33	43	,	,	PUNCT
app-717	33	44	progesterone	progesterone	NOUN
app-717	33	45	,	,	PUNCT
app-717	33	46	and	and	CCONJ
app-717	33	47	cortisol	cortisol	ADJ
app-717	33	48	playing	play	VERB
app-717	33	49	key	key	ADJ
app-717	33	50	roles	role	NOUN
app-717	33	51	in	in	ADP
app-717	33	52	mood	mood	NOUN
app-717	33	53	regulation	regulation	NOUN
app-717	33	54	.	.	PUNCT
app-717	34	1	understanding	understand	VERB
app-717	34	2	these	these	DET
app-717	34	3	hormonal	hormonal	ADJ
app-717	34	4	changes	change	NOUN
app-717	34	5	is	be	AUX
app-717	34	6	critical	critical	ADJ
app-717	34	7	for	for	ADP
app-717	34	8	addressing	address	VERB
app-717	34	9	menopausal	menopausal	ADJ
app-717	34	10	mood	mood	NOUN
app-717	34	11	disorders	disorder	NOUN
app-717	34	12	effectively	effectively	ADV
app-717	34	13	.	.	PUNCT
app-717	35	1	standard	standard	ADJ
app-717	35	2	mental	mental	ADJ
app-717	35	3	health	health	NOUN
app-717	35	4	interventions	intervention	NOUN
app-717	35	5	,	,	PUNCT
app-717	35	6	such	such	ADJ
app-717	35	7	as	as	ADP
app-717	35	8	lifestyle	lifestyle	NOUN
app-717	35	9	modification	modification	NOUN
app-717	35	10	and	and	CCONJ
app-717	35	11	antidepressants	antidepressant	NOUN
app-717	35	12	,	,	PUNCT
app-717	35	13	are	be	AUX
app-717	35	14	often	often	ADV
app-717	35	15	insufficient	insufficient	ADJ
app-717	35	16	in	in	ADP
app-717	35	17	addressing	address	VERB
app-717	35	18	menopausal	menopausal	ADJ
app-717	35	19	mood	mood	NOUN
app-717	35	20	disorders	disorder	NOUN
app-717	35	21	.	.	PUNCT
app-717	36	1	healthcare	healthcare	NOUN
app-717	36	2	providers	provider	NOUN
app-717	36	3	often	often	ADV
app-717	36	4	54	54	NUM
app-717	36	5	recommend	recommend	VERB
app-717	36	6	stress	stress	NOUN
app-717	36	7	reduction	reduction	NOUN
app-717	36	8	techniques	technique	NOUN
app-717	36	9	and	and	CCONJ
app-717	36	10	psychotherapies	psychotherapy	NOUN
app-717	36	11	,	,	PUNCT
app-717	36	12	like	like	ADP
app-717	36	13	cognitive	cognitive	ADJ
app-717	36	14	-	-	PUNCT
app-717	36	15	behavioral	behavioral	ADJ
app-717	36	16	therapy	therapy	NOUN
app-717	36	17	,	,	PUNCT
app-717	36	18	as	as	ADP
app-717	36	19	the	the	DET
app-717	36	20	first	first	ADJ
app-717	36	21	intervention	intervention	NOUN
app-717	36	22	.	.	PUNCT
app-717	37	1	antidepressants	antidepressant	NOUN
app-717	37	2	,	,	PUNCT
app-717	37	3	particularly	particularly	ADV
app-717	37	4	ssris	ssris	NOUN
app-717	37	5	,	,	PUNCT
app-717	37	6	are	be	AUX
app-717	37	7	usually	usually	ADV
app-717	37	8	the	the	DET
app-717	37	9	next	next	ADJ
app-717	37	10	treatment	treatment	NOUN
app-717	37	11	option	option	NOUN
app-717	37	12	.	.	PUNCT
app-717	38	1	however	however	ADV
app-717	38	2	,	,	PUNCT
app-717	38	3	many	many	ADJ
app-717	38	4	medications	medication	NOUN
app-717	38	5	that	that	PRON
app-717	38	6	had	have	AUX
app-717	38	7	previously	previously	ADV
app-717	38	8	helped	help	VERB
app-717	38	9	are	be	AUX
app-717	38	10	no	no	ADV
app-717	38	11	longer	long	ADV
app-717	38	12	effective	effective	ADJ
app-717	38	13	,	,	PUNCT
app-717	38	14	or	or	CCONJ
app-717	38	15	a	a	DET
app-717	38	16	much	much	ADV
app-717	38	17	higher	high	ADJ
app-717	38	18	dose	dose	NOUN
app-717	38	19	is	be	AUX
app-717	38	20	required	require	VERB
app-717	38	21	to	to	PART
app-717	38	22	have	have	VERB
app-717	38	23	the	the	DET
app-717	38	24	same	same	ADJ
app-717	38	25	effect	effect	NOUN
app-717	38	26	(	(	PUNCT
app-717	38	27	worley	worley	NOUN
app-717	38	28	et	et	PROPN
app-717	38	29	al	al	PROPN
app-717	38	30	.	.	PROPN
app-717	38	31	,	,	PUNCT
app-717	38	32	2012	2012	NUM
app-717	38	33	;	;	PUNCT
app-717	38	34	grigoriadis	grigoriadis	PROPN
app-717	38	35	et	et	PROPN
app-717	38	36	al	al	PROPN
app-717	38	37	.	.	PROPN
app-717	38	38	,	,	PUNCT
app-717	38	39	2006	2006	NUM
app-717	38	40	,	,	PUNCT
app-717	38	41	as	as	SCONJ
app-717	38	42	cited	cite	VERB
app-717	38	43	by	by	ADP
app-717	38	44	behrman	behrman	PROPN
app-717	38	45	&	&	CCONJ
app-717	38	46	crockett	crockett	PROPN
app-717	38	47	,	,	PUNCT
app-717	38	48	2023	2023	NUM
app-717	38	49	)	)	PUNCT
app-717	38	50	.	.	PUNCT
app-717	39	1	current	current	ADJ
app-717	39	2	guidelines	guideline	NOUN
app-717	39	3	are	be	AUX
app-717	39	4	to	to	PART
app-717	39	5	treat	treat	VERB
app-717	39	6	menopausal	menopausal	ADJ
app-717	39	7	depression	depression	NOUN
app-717	39	8	as	as	ADP
app-717	39	9	any	any	DET
app-717	39	10	other	other	ADJ
app-717	39	11	depressive	depressive	ADJ
app-717	39	12	episode	episode	NOUN
app-717	39	13	.	.	PUNCT
app-717	40	1	however	however	ADV
app-717	40	2	,	,	PUNCT
app-717	40	3	it	it	PRON
app-717	40	4	is	be	AUX
app-717	40	5	known	know	VERB
app-717	40	6	that	that	SCONJ
app-717	40	7	periand	periand	NOUN
app-717	40	8	postmenopausal	postmenopausal	NOUN
app-717	40	9	people	people	NOUN
app-717	40	10	do	do	AUX
app-717	40	11	not	not	PART
app-717	40	12	respond	respond	VERB
app-717	40	13	to	to	ADP
app-717	40	14	ssris	ssris	VERB
app-717	40	15	as	as	ADV
app-717	40	16	effectively	effectively	ADV
app-717	40	17	as	as	ADP
app-717	40	18	other	other	ADJ
app-717	40	19	demographics	demographic	NOUN
app-717	40	20	,	,	PUNCT
app-717	40	21	and	and	CCONJ
app-717	40	22	rates	rate	NOUN
app-717	40	23	of	of	ADP
app-717	40	24	discontinuation	discontinuation	NOUN
app-717	40	25	due	due	ADP
app-717	40	26	to	to	ADP
app-717	40	27	adverse	adverse	ADJ
app-717	40	28	events	event	NOUN
app-717	40	29	are	be	AUX
app-717	40	30	significant	significant	ADJ
app-717	40	31	(	(	PUNCT
app-717	40	32	wu	wu	PROPN
app-717	40	33	et	et	PROPN
app-717	40	34	al	al	PROPN
app-717	40	35	.	.	PROPN
app-717	40	36	,	,	PUNCT
app-717	40	37	2020	2020	NUM
app-717	40	38	,	,	PUNCT
app-717	40	39	as	as	SCONJ
app-717	40	40	cited	cite	VERB
app-717	40	41	by	by	ADP
app-717	40	42	behrman	behrman	PROPN
app-717	40	43	&	&	CCONJ
app-717	40	44	crockett	crockett	PROPN
app-717	40	45	,	,	PUNCT
app-717	40	46	2023	2023	NUM
app-717	40	47	)	)	PUNCT
app-717	40	48	.	.	PUNCT
app-717	41	1	hormonal	hormonal	ADJ
app-717	41	2	therapies	therapy	NOUN
app-717	41	3	may	may	AUX
app-717	41	4	be	be	AUX
app-717	41	5	more	more	ADV
app-717	41	6	effective	effective	ADJ
app-717	41	7	but	but	CCONJ
app-717	41	8	remain	remain	VERB
app-717	41	9	underutilized	underutilized	ADJ
app-717	41	10	due	due	ADP
app-717	41	11	to	to	ADP
app-717	41	12	safety	safety	NOUN
app-717	41	13	concerns	concern	NOUN
app-717	41	14	and	and	CCONJ
app-717	41	15	a	a	DET
app-717	41	16	lack	lack	NOUN
app-717	41	17	of	of	ADP
app-717	41	18	sufficient	sufficient	ADJ
app-717	41	19	knowledge	knowledge	NOUN
app-717	41	20	among	among	ADP
app-717	41	21	mental	mental	ADJ
app-717	41	22	health	health	NOUN
app-717	41	23	professionals	professional	NOUN
app-717	41	24	about	about	ADP
app-717	41	25	their	their	PRON
app-717	41	26	use	use	NOUN
app-717	41	27	in	in	ADP
app-717	41	28	treating	treat	VERB
app-717	41	29	mood	mood	NOUN
app-717	41	30	disorders	disorder	NOUN
app-717	41	31	(	(	PUNCT
app-717	41	32	behrman	behrman	NOUN
app-717	41	33	&	&	CCONJ
app-717	41	34	crockett	crockett	PROPN
app-717	41	35	,	,	PUNCT
app-717	41	36	2023	2023	NUM
app-717	41	37	)	)	PUNCT
app-717	41	38	.	.	PUNCT
app-717	42	1	the	the	DET
app-717	42	2	interplay	interplay	NOUN
app-717	42	3	between	between	ADP
app-717	42	4	hormonal	hormonal	ADJ
app-717	42	5	shifts	shift	NOUN
app-717	42	6	and	and	CCONJ
app-717	42	7	mental	mental	ADJ
app-717	42	8	health	health	NOUN
app-717	42	9	challenges	challenge	NOUN
app-717	42	10	underscores	underscore	VERB
app-717	42	11	the	the	DET
app-717	42	12	necessity	necessity	NOUN
app-717	42	13	for	for	ADP
app-717	42	14	a	a	DET
app-717	42	15	nuanced	nuanced	ADJ
app-717	42	16	understanding	understanding	NOUN
app-717	42	17	of	of	ADP
app-717	42	18	menopause	menopause	NOUN
app-717	42	19	in	in	ADP
app-717	42	20	clinical	clinical	ADJ
app-717	42	21	settings	setting	NOUN
app-717	42	22	.	.	PUNCT
app-717	43	1	conventional	conventional	ADJ
app-717	43	2	mental	mental	ADJ
app-717	43	3	health	health	NOUN
app-717	43	4	treatments	treatment	NOUN
app-717	43	5	fail	fail	VERB
app-717	43	6	to	to	PART
app-717	43	7	account	account	VERB
app-717	43	8	for	for	ADP
app-717	43	9	the	the	DET
app-717	43	10	unique	unique	ADJ
app-717	43	11	physiological	physiological	ADJ
app-717	43	12	changes	change	NOUN
app-717	43	13	during	during	ADP
app-717	43	14	menopause	menopause	NOUN
app-717	43	15	,	,	PUNCT
app-717	43	16	highlighting	highlight	VERB
app-717	43	17	a	a	DET
app-717	43	18	critical	critical	ADJ
app-717	43	19	gap	gap	NOUN
app-717	43	20	in	in	ADP
app-717	43	21	care	care	NOUN
app-717	43	22	.	.	PUNCT
app-717	44	1	integrative	integrative	ADJ
app-717	44	2	approaches	approach	NOUN
app-717	44	3	and	and	CCONJ
app-717	44	4	targeted	target	VERB
app-717	44	5	interventions	intervention	NOUN
app-717	44	6	are	be	AUX
app-717	44	7	needed	need	VERB
app-717	44	8	to	to	PART
app-717	44	9	support	support	VERB
app-717	44	10	women	woman	NOUN
app-717	44	11	during	during	ADP
app-717	44	12	this	this	DET
app-717	44	13	critical	critical	ADJ
app-717	44	14	stage	stage	NOUN
app-717	44	15	of	of	ADP
app-717	44	16	life	life	NOUN
app-717	44	17	.	.	PUNCT
app-717	45	1	neuroscience	neuroscience	NOUN
app-717	45	2	of	of	ADP
app-717	45	3	hormonal	hormonal	ADJ
app-717	45	4	influence	influence	NOUN
app-717	45	5	on	on	ADP
app-717	45	6	mental	mental	ADJ
app-717	45	7	health	health	NOUN
app-717	45	8	during	during	ADP
app-717	45	9	menopause	menopause	NOUN
app-717	45	10	neurotransmitters	neurotransmitter	NOUN
app-717	45	11	such	such	ADJ
app-717	45	12	as	as	ADP
app-717	45	13	serotonin	serotonin	NOUN
app-717	45	14	,	,	PUNCT
app-717	45	15	norepinephrine	norepinephrine	NOUN
app-717	45	16	,	,	PUNCT
app-717	45	17	and	and	CCONJ
app-717	45	18	dopamine	dopamine	NOUN
app-717	45	19	play	play	VERB
app-717	45	20	a	a	DET
app-717	45	21	crucial	crucial	ADJ
app-717	45	22	role	role	NOUN
app-717	45	23	in	in	ADP
app-717	45	24	modulating	modulate	VERB
app-717	45	25	both	both	CCONJ
app-717	45	26	vasomotor	vasomotor	NOUN
app-717	45	27	and	and	CCONJ
app-717	45	28	mood	mood	NOUN
app-717	45	29	disorders	disorder	NOUN
app-717	45	30	.	.	PUNCT
app-717	46	1	dysregulation	dysregulation	NOUN
app-717	46	2	of	of	ADP
app-717	46	3	these	these	DET
app-717	46	4	pathways	pathway	NOUN
app-717	46	5	,	,	PUNCT
app-717	46	6	particularly	particularly	ADV
app-717	46	7	in	in	ADP
app-717	46	8	the	the	DET
app-717	46	9	prefrontal	prefrontal	ADJ
app-717	46	10	cortex	cortex	NOUN
app-717	46	11	and	and	CCONJ
app-717	46	12	limbic	limbic	ADJ
app-717	46	13	system	system	NOUN
app-717	46	14	,	,	PUNCT
app-717	46	15	key	key	ADJ
app-717	46	16	regions	region	NOUN
app-717	46	17	of	of	ADP
app-717	46	18	the	the	DET
app-717	46	19	central	central	ADJ
app-717	46	20	nervous	nervous	ADJ
app-717	46	21	system	system	NOUN
app-717	46	22	involved	involve	VERB
app-717	46	23	in	in	ADP
app-717	46	24	mood	mood	NOUN
app-717	46	25	control	control	NOUN
app-717	46	26	,	,	PUNCT
app-717	46	27	can	can	AUX
app-717	46	28	contribute	contribute	VERB
app-717	46	29	to	to	ADP
app-717	46	30	the	the	DET
app-717	46	31	onset	onset	NOUN
app-717	46	32	of	of	ADP
app-717	46	33	depression	depression	NOUN
app-717	46	34	(	(	PUNCT
app-717	46	35	giannini	giannini	PROPN
app-717	46	36	et	et	PROPN
app-717	46	37	al	al	PROPN
app-717	46	38	.	.	PROPN
app-717	46	39	,	,	PUNCT
app-717	46	40	2021	2021	NUM
app-717	46	41	)	)	PUNCT
app-717	46	42	.	.	PUNCT
app-717	47	1	estrogen	estrogen	NOUN
app-717	47	2	has	have	VERB
app-717	47	3	a	a	DET
app-717	47	4	role	role	NOUN
app-717	47	5	in	in	ADP
app-717	47	6	the	the	DET
app-717	47	7	modulation	modulation	NOUN
app-717	47	8	of	of	ADP
app-717	47	9	serotonin	serotonin	NOUN
app-717	47	10	and	and	CCONJ
app-717	47	11	the	the	DET
app-717	47	12	serotonergic	serotonergic	ADJ
app-717	47	13	pathways	pathway	NOUN
app-717	47	14	,	,	PUNCT
app-717	47	15	considered	consider	VERB
app-717	47	16	a	a	DET
app-717	47	17	root	root	NOUN
app-717	47	18	neurobiological	neurobiological	ADJ
app-717	47	19	cause	cause	NOUN
app-717	47	20	of	of	ADP
app-717	47	21	depression	depression	NOUN
app-717	47	22	(	(	PUNCT
app-717	47	23	herson	herson	PROPN
app-717	47	24	&	&	CCONJ
app-717	47	25	kulkarni	kulkarni	PROPN
app-717	47	26	,	,	PUNCT
app-717	47	27	2022	2022	NUM
app-717	47	28	,	,	PUNCT
app-717	47	29	as	as	SCONJ
app-717	47	30	cited	cite	VERB
app-717	47	31	in	in	ADP
app-717	47	32	behrman	behrman	PROPN
app-717	47	33	&	&	CCONJ
app-717	47	34	crockett	crockett	PROPN
app-717	47	35	,	,	PUNCT
app-717	47	36	2023	2023	NUM
app-717	47	37	)	)	PUNCT
app-717	47	38	.	.	PUNCT
app-717	48	1	estrogen	estrogen	NOUN
app-717	48	2	affects	affect	VERB
app-717	48	3	the	the	DET
app-717	48	4	concentration	concentration	NOUN
app-717	48	5	of	of	ADP
app-717	48	6	serotonin	serotonin	NOUN
app-717	48	7	by	by	ADP
app-717	48	8	increasing	increase	VERB
app-717	48	9	the	the	DET
app-717	48	10	rate	rate	NOUN
app-717	48	11	of	of	ADP
app-717	48	12	monoamine	monoamine	ADJ
app-717	48	13	oxidase	oxidase	NOUN
app-717	48	14	(	(	PUNCT
app-717	48	15	mao	mao	PROPN
app-717	48	16	)	)	PUNCT
app-717	48	17	,	,	PUNCT
app-717	48	18	an	an	DET
app-717	48	19	enzyme	enzyme	NOUN
app-717	48	20	responsible	responsible	ADJ
app-717	48	21	for	for	ADP
app-717	48	22	serotonin	serotonin	NOUN
app-717	48	23	catabolism	catabolism	NOUN
app-717	48	24	.	.	PUNCT
app-717	49	1	estrogen	estrogen	NOUN
app-717	49	2	is	be	AUX
app-717	49	3	also	also	ADV
app-717	49	4	linked	link	VERB
app-717	49	5	to	to	PART
app-717	49	6	neuron	neuron	NOUN
app-717	49	7	activity	activity	NOUN
app-717	49	8	due	due	ADP
app-717	49	9	to	to	ADP
app-717	49	10	its	its	PRON
app-717	49	11	ability	ability	NOUN
app-717	49	12	to	to	PART
app-717	49	13	affect	affect	VERB
app-717	49	14	cerebral	cerebral	ADJ
app-717	49	15	blood	blood	NOUN
app-717	49	16	flow	flow	NOUN
app-717	49	17	,	,	PUNCT
app-717	49	18	glucose	glucose	NOUN
app-717	49	19	levels	level	NOUN
app-717	49	20	,	,	PUNCT
app-717	49	21	neuronal	neuronal	ADJ
app-717	49	22	growth	growth	NOUN
app-717	49	23	,	,	PUNCT
app-717	49	24	and	and	CCONJ
app-717	49	25	synaptic	synaptic	ADJ
app-717	49	26	activity	activity	NOUN
app-717	49	27	(	(	PUNCT
app-717	49	28	giannini	giannini	PROPN
app-717	49	29	et	et	PROPN
app-717	49	30	al	al	PROPN
app-717	49	31	.	.	PROPN
app-717	49	32	,	,	PUNCT
app-717	49	33	2021	2021	NUM
app-717	49	34	)	)	PUNCT
app-717	49	35	.	.	PUNCT
app-717	50	1	other	other	ADJ
app-717	50	2	neurotransmitter	neurotransmitter	NOUN
app-717	50	3	pathways	pathway	NOUN
app-717	50	4	linked	link	VERB
app-717	50	5	to	to	ADP
app-717	50	6	changes	change	NOUN
app-717	50	7	in	in	ADP
app-717	50	8	mood	mood	NOUN
app-717	50	9	,	,	PUNCT
app-717	50	10	such	such	ADJ
app-717	50	11	as	as	ADP
app-717	50	12	dehydroepiandrosterone	dehydroepiandrosterone	PROPN
app-717	50	13	sulfate	sulfate	NOUN
app-717	50	14	and	and	CCONJ
app-717	50	15	gamma	gamma	NOUN
app-717	50	16	-	-	PUNCT
app-717	50	17	aminobutyric	aminobutyric	ADJ
app-717	50	18	acid	acid	NOUN
app-717	50	19	(	(	PUNCT
app-717	50	20	gaba	gaba	PROPN
app-717	50	21	)	)	PUNCT
app-717	50	22	,	,	PUNCT
app-717	50	23	are	be	AUX
app-717	50	24	also	also	ADV
app-717	50	25	affected	affect	VERB
app-717	50	26	by	by	ADP
app-717	50	27	the	the	DET
app-717	50	28	menopausal	menopausal	ADJ
app-717	50	29	transition	transition	NOUN
app-717	50	30	(	(	PUNCT
app-717	50	31	behrman	behrman	NOUN
app-717	50	32	&	&	CCONJ
app-717	50	33	crockett	crockett	PROPN
app-717	50	34	,	,	PUNCT
app-717	50	35	2023	2023	NUM
app-717	50	36	)	)	PUNCT
app-717	50	37	.	.	PUNCT
app-717	51	1	estrogen	estrogen	NOUN
app-717	51	2	significantly	significantly	ADV
app-717	51	3	affects	affect	VERB
app-717	51	4	moodregulating	moodregulate	VERB
app-717	51	5	brain	brain	NOUN
app-717	51	6	areas	area	NOUN
app-717	51	7	such	such	ADJ
app-717	51	8	as	as	ADP
app-717	51	9	the	the	DET
app-717	51	10	hippocampus	hippocampus	NOUN
app-717	51	11	and	and	CCONJ
app-717	51	12	amygdala	amygdala	NOUN
app-717	51	13	by	by	ADP
app-717	51	14	enhancing	enhance	VERB
app-717	51	15	synaptic	synaptic	ADJ
app-717	51	16	plasticity	plasticity	NOUN
app-717	51	17	,	,	PUNCT
app-717	51	18	promoting	promote	VERB
app-717	51	19	neuronal	neuronal	ADJ
app-717	51	20	growth	growth	NOUN
app-717	51	21	,	,	PUNCT
app-717	51	22	and	and	CCONJ
app-717	51	23	modulating	modulate	VERB
app-717	51	24	neurotransmitter	neurotransmitter	NOUN
app-717	51	25	systems	system	NOUN
app-717	51	26	,	,	PUNCT
app-717	51	27	collectively	collectively	ADV
app-717	51	28	contributing	contribute	VERB
app-717	51	29	to	to	ADP
app-717	51	30	improved	improved	ADJ
app-717	51	31	mood	mood	NOUN
app-717	51	32	regulation	regulation	NOUN
app-717	51	33	and	and	CCONJ
app-717	51	34	stress	stress	NOUN
app-717	51	35	resilience	resilience	NOUN
app-717	51	36	(	(	PUNCT
app-717	51	37	behrman	behrman	NOUN
app-717	51	38	&	&	CCONJ
app-717	51	39	crockett	crockett	PROPN
app-717	51	40	,	,	PUNCT
app-717	51	41	2023	2023	NUM
app-717	51	42	)	)	PUNCT
app-717	51	43	.	.	PUNCT
app-717	52	1	the	the	DET
app-717	52	2	progesterone	progesterone	NOUN
app-717	52	3	derivative	derivative	ADJ
app-717	52	4	allopregnanolone	allopregnanolone	NOUN
app-717	52	5	“	"	PUNCT
app-717	52	6	interacts	interact	VERB
app-717	52	7	with	with	ADP
app-717	52	8	gamma	gamma	NOUN
app-717	52	9	-	-	PUNCT
app-717	52	10	aminobutyric	aminobutyric	ADJ
app-717	52	11	acid	acid	NOUN
app-717	52	12	type	type	NOUN
app-717	52	13	a	a	DET
app-717	52	14	(	(	PUNCT
app-717	52	15	gaba	gaba	NOUN
app-717	52	16	-	-	PUNCT
app-717	52	17	a	a	NOUN
app-717	52	18	)	)	PUNCT
app-717	52	19	receptors	receptor	NOUN
app-717	52	20	even	even	ADV
app-717	52	21	at	at	ADP
app-717	52	22	nanomolar	nanomolar	ADJ
app-717	52	23	concentrations	concentration	NOUN
app-717	52	24	and	and	CCONJ
app-717	52	25	induces	induce	VERB
app-717	52	26	significant	significant	ADJ
app-717	52	27	anti	anti	ADJ
app-717	52	28	-	-	ADJ
app-717	52	29	depressant	depressant	ADJ
app-717	52	30	,	,	PUNCT
app-717	52	31	anti	anti	ADJ
app-717	52	32	-	-	ADJ
app-717	52	33	stress	stress	ADJ
app-717	52	34	,	,	PUNCT
app-717	52	35	sedative	sedative	NOUN
app-717	52	36	,	,	PUNCT
app-717	52	37	and	and	CCONJ
app-717	52	38	anxiolytic	anxiolytic	ADJ
app-717	52	39	effects	effect	NOUN
app-717	52	40	”	"	PUNCT
app-717	52	41	(	(	PUNCT
app-717	52	42	stefaniak	stefaniak	PROPN
app-717	52	43	et	et	PROPN
app-717	52	44	al	al	PROPN
app-717	52	45	.	.	PROPN
app-717	52	46	,	,	PUNCT
app-717	52	47	2023	2023	NUM
app-717	52	48	,	,	PUNCT
app-717	52	49	p.	p.	NOUN
app-717	52	50	520	520	NUM
app-717	52	51	)	)	PUNCT
app-717	52	52	.	.	PUNCT
app-717	53	1	low	low	ADJ
app-717	53	2	to	to	ADP
app-717	53	3	moderate	moderate	ADJ
app-717	53	4	concentrations	concentration	NOUN
app-717	53	5	of	of	ADP
app-717	53	6	allopregnanolone	allopregnanolone	NOUN
app-717	53	7	increase	increase	NOUN
app-717	53	8	amygdala	amygdala	NOUN
app-717	53	9	activity	activity	NOUN
app-717	53	10	as	as	SCONJ
app-717	53	11	measured	measure	VERB
app-717	53	12	by	by	ADP
app-717	53	13	functional	functional	ADJ
app-717	53	14	magnetic	magnetic	ADJ
app-717	53	15	resonance	resonance	NOUN
app-717	53	16	imaging	imaging	NOUN
app-717	53	17	(	(	PUNCT
app-717	53	18	fmri	fmri	PROPN
app-717	53	19	)	)	PUNCT
app-717	53	20	,	,	PUNCT
app-717	53	21	similar	similar	ADJ
app-717	53	22	to	to	ADP
app-717	53	23	changes	change	NOUN
app-717	53	24	experienced	experience	VERB
app-717	53	25	during	during	ADP
app-717	53	26	heightened	heightened	ADJ
app-717	53	27	anxiety	anxiety	NOUN
app-717	53	28	.	.	PUNCT
app-717	54	1	when	when	SCONJ
app-717	54	2	concentrations	concentration	NOUN
app-717	54	3	increased	increase	VERB
app-717	54	4	,	,	PUNCT
app-717	54	5	amygdala	amygdala	NOUN
app-717	54	6	activity	activity	NOUN
app-717	54	7	slowed	slow	VERB
app-717	54	8	,	,	PUNCT
app-717	54	9	resembling	resemble	VERB
app-717	54	10	the	the	DET
app-717	54	11	effect	effect	NOUN
app-717	54	12	of	of	ADP
app-717	54	13	sedatives	sedative	NOUN
app-717	54	14	like	like	ADP
app-717	54	15	benzodiazepines	benzodiazepine	NOUN
app-717	54	16	(	(	PUNCT
app-717	54	17	stefaniak	stefaniak	PROPN
app-717	54	18	et	et	PROPN
app-717	54	19	al	al	PROPN
app-717	54	20	.	.	PROPN
app-717	54	21	,	,	PUNCT
app-717	54	22	2023	2023	NUM
app-717	54	23	)	)	PUNCT
app-717	54	24	.	.	PUNCT
app-717	55	1	55	55	NUM
app-717	55	2	hormone	hormone	NOUN
app-717	55	3	replacement	replacement	NOUN
app-717	55	4	therapy	therapy	NOUN
app-717	55	5	hrt	hrt	PROPN
app-717	55	6	is	be	AUX
app-717	55	7	an	an	DET
app-717	55	8	effective	effective	ADJ
app-717	55	9	treatment	treatment	NOUN
app-717	55	10	for	for	ADP
app-717	55	11	various	various	ADJ
app-717	55	12	adverse	adverse	ADJ
app-717	55	13	symptoms	symptom	NOUN
app-717	55	14	associated	associate	VERB
app-717	55	15	with	with	ADP
app-717	55	16	menopause	menopause	NOUN
app-717	55	17	,	,	PUNCT
app-717	55	18	including	include	VERB
app-717	55	19	vasomotor	vasomotor	NOUN
app-717	55	20	symptoms	symptom	NOUN
app-717	55	21	(	(	PUNCT
app-717	55	22	such	such	ADJ
app-717	55	23	as	as	ADP
app-717	55	24	intense	intense	ADJ
app-717	55	25	heat	heat	NOUN
app-717	55	26	,	,	PUNCT
app-717	55	27	sweating	sweating	NOUN
app-717	55	28	,	,	PUNCT
app-717	55	29	and	and	CCONJ
app-717	55	30	flushing	flush	VERB
app-717	55	31	)	)	PUNCT
app-717	55	32	and	and	CCONJ
app-717	55	33	genitourinary	genitourinary	ADJ
app-717	55	34	syndrome	syndrome	NOUN
app-717	55	35	(	(	PUNCT
app-717	55	36	characterized	characterize	VERB
app-717	55	37	by	by	ADP
app-717	55	38	vaginal	vaginal	ADJ
app-717	55	39	dryness	dryness	NOUN
app-717	55	40	,	,	PUNCT
app-717	55	41	irritation	irritation	NOUN
app-717	55	42	,	,	PUNCT
app-717	55	43	burning	burning	NOUN
app-717	55	44	,	,	PUNCT
app-717	55	45	painful	painful	ADJ
app-717	55	46	intercourse	intercourse	NOUN
app-717	55	47	,	,	PUNCT
app-717	55	48	recurrent	recurrent	ADJ
app-717	55	49	urinary	urinary	ADJ
app-717	55	50	tract	tract	NOUN
app-717	55	51	infections	infection	NOUN
app-717	55	52	,	,	PUNCT
app-717	55	53	and	and	CCONJ
app-717	55	54	urinary	urinary	ADJ
app-717	55	55	incontinence	incontinence	NOUN
app-717	55	56	)	)	PUNCT
app-717	55	57	.	.	PUNCT
app-717	56	1	additionally	additionally	ADV
app-717	56	2	,	,	PUNCT
app-717	56	3	multiple	multiple	ADJ
app-717	56	4	randomized	randomized	ADJ
app-717	56	5	trials	trial	NOUN
app-717	56	6	have	have	AUX
app-717	56	7	demonstrated	demonstrate	VERB
app-717	56	8	hrt	hrt	PROPN
app-717	56	9	's	's	PART
app-717	56	10	positive	positive	ADJ
app-717	56	11	effects	effect	NOUN
app-717	56	12	on	on	ADP
app-717	56	13	cardiovascular	cardiovascular	ADJ
app-717	56	14	,	,	PUNCT
app-717	56	15	endocrine	endocrine	NOUN
app-717	56	16	,	,	PUNCT
app-717	56	17	and	and	CCONJ
app-717	56	18	bone	bone	NOUN
app-717	56	19	health	health	NOUN
app-717	56	20	,	,	PUNCT
app-717	56	21	with	with	ADP
app-717	56	22	evidence	evidence	NOUN
app-717	56	23	suggesting	suggest	VERB
app-717	56	24	a	a	DET
app-717	56	25	reduction	reduction	NOUN
app-717	56	26	in	in	ADP
app-717	56	27	all	all	DET
app-717	56	28	-	-	PUNCT
app-717	56	29	cause	cause	NOUN
app-717	56	30	mortality	mortality	NOUN
app-717	56	31	among	among	ADP
app-717	56	32	recently	recently	ADV
app-717	56	33	menopausal	menopausal	ADJ
app-717	56	34	women	woman	NOUN
app-717	56	35	(	(	PUNCT
app-717	56	36	flores	flore	NOUN
app-717	56	37	et	et	PROPN
app-717	56	38	al	al	PROPN
app-717	56	39	.	.	PROPN
app-717	56	40	,	,	PUNCT
app-717	56	41	2021	2021	NUM
app-717	56	42	)	)	PUNCT
app-717	56	43	.	.	PUNCT
app-717	57	1	however	however	ADV
app-717	57	2	,	,	PUNCT
app-717	57	3	the	the	DET
app-717	57	4	2002	2002	NUM
app-717	57	5	whi	whi	NOUN
app-717	57	6	report	report	NOUN
app-717	57	7	delivered	deliver	VERB
app-717	57	8	transformative	transformative	ADJ
app-717	57	9	findings	finding	NOUN
app-717	57	10	into	into	ADP
app-717	57	11	hrt	hrt	PROPN
app-717	57	12	risks	risk	NOUN
app-717	57	13	of	of	ADP
app-717	57	14	breast	breast	NOUN
app-717	57	15	cancer	cancer	NOUN
app-717	57	16	and	and	CCONJ
app-717	57	17	cardiovascular	cardiovascular	ADJ
app-717	57	18	disease	disease	NOUN
app-717	57	19	in	in	ADP
app-717	57	20	older	old	ADJ
app-717	57	21	postmenopausal	postmenopausal	ADJ
app-717	57	22	women	woman	NOUN
app-717	57	23	,	,	PUNCT
app-717	57	24	driving	drive	VERB
app-717	57	25	a	a	DET
app-717	57	26	“	"	PUNCT
app-717	57	27	seismic	seismic	ADJ
app-717	57	28	shift	shift	NOUN
app-717	57	29	”	"	PUNCT
app-717	57	30	in	in	ADP
app-717	57	31	menopause	menopause	NOUN
app-717	57	32	management	management	NOUN
app-717	57	33	and	and	CCONJ
app-717	57	34	influencing	influence	VERB
app-717	57	35	perspectives	perspective	NOUN
app-717	57	36	that	that	PRON
app-717	57	37	persist	persist	VERB
app-717	57	38	today	today	NOUN
app-717	57	39	(	(	PUNCT
app-717	57	40	flores	flores	PROPN
app-717	57	41	et	et	PROPN
app-717	57	42	al	al	PROPN
app-717	57	43	.	.	PROPN
app-717	57	44	,	,	PUNCT
app-717	57	45	2021	2021	NUM
app-717	57	46	,	,	PUNCT
app-717	57	47	p.	p.	NOUN
app-717	57	48	720	720	NUM
app-717	57	49	)	)	PUNCT
app-717	57	50	.	.	PUNCT
app-717	58	1	the	the	DET
app-717	58	2	whi	whi	PROPN
app-717	58	3	study	study	NOUN
app-717	58	4	included	include	VERB
app-717	58	5	a	a	DET
app-717	58	6	large	large	ADJ
app-717	58	7	population	population	NOUN
app-717	58	8	of	of	ADP
app-717	58	9	older	old	ADJ
app-717	58	10	postmenopausal	postmenopausal	ADJ
app-717	58	11	women	woman	NOUN
app-717	58	12	more	more	ADJ
app-717	58	13	than	than	ADP
app-717	58	14	10	10	NUM
app-717	58	15	years	year	NOUN
app-717	58	16	after	after	ADP
app-717	58	17	the	the	DET
app-717	58	18	cessation	cessation	NOUN
app-717	58	19	of	of	ADP
app-717	58	20	menses	mense	NOUN
app-717	58	21	.	.	PUNCT
app-717	59	1	these	these	DET
app-717	59	2	women	woman	NOUN
app-717	59	3	were	be	AUX
app-717	59	4	more	more	ADV
app-717	59	5	likely	likely	ADJ
app-717	59	6	to	to	PART
app-717	59	7	have	have	VERB
app-717	59	8	pre	pre	ADJ
app-717	59	9	-	-	ADJ
app-717	59	10	existing	existing	ADJ
app-717	59	11	conditions	condition	NOUN
app-717	59	12	,	,	PUNCT
app-717	59	13	such	such	ADJ
app-717	59	14	as	as	ADP
app-717	59	15	cardiovascular	cardiovascular	ADJ
app-717	59	16	disease	disease	NOUN
app-717	59	17	,	,	PUNCT
app-717	59	18	making	make	VERB
app-717	59	19	them	they	PRON
app-717	59	20	more	more	ADV
app-717	59	21	prone	prone	ADJ
app-717	59	22	to	to	ADP
app-717	59	23	adverse	adverse	ADJ
app-717	59	24	outcomes	outcome	NOUN
app-717	59	25	.	.	PUNCT
app-717	60	1	the	the	DET
app-717	60	2	study	study	NOUN
app-717	60	3	also	also	ADV
app-717	60	4	used	use	VERB
app-717	60	5	a	a	DET
app-717	60	6	combination	combination	NOUN
app-717	60	7	of	of	ADP
app-717	60	8	estrogen	estrogen	NOUN
app-717	60	9	and	and	CCONJ
app-717	60	10	medroxyprogesterone	medroxyprogesterone	NOUN
app-717	60	11	acetate	acetate	NOUN
app-717	60	12	(	(	PUNCT
app-717	60	13	mpa	mpa	PROPN
app-717	60	14	)	)	PUNCT
app-717	60	15	,	,	PUNCT
app-717	60	16	a	a	DET
app-717	60	17	synthetic	synthetic	ADJ
app-717	60	18	progestin	progestin	NOUN
app-717	60	19	.	.	PUNCT
app-717	61	1	unlike	unlike	ADP
app-717	61	2	natural	natural	ADJ
app-717	61	3	progesterone	progesterone	NOUN
app-717	61	4	,	,	PUNCT
app-717	61	5	mpa	mpa	PROPN
app-717	61	6	has	have	AUX
app-717	61	7	been	be	AUX
app-717	61	8	associated	associate	VERB
app-717	61	9	with	with	ADP
app-717	61	10	an	an	DET
app-717	61	11	increased	increase	VERB
app-717	61	12	risk	risk	NOUN
app-717	61	13	of	of	ADP
app-717	61	14	breast	breast	NOUN
app-717	61	15	cancer	cancer	NOUN
app-717	61	16	and	and	CCONJ
app-717	61	17	cardiovascular	cardiovascular	ADJ
app-717	61	18	disease	disease	NOUN
app-717	61	19	(	(	PUNCT
app-717	61	20	manson	manson	PROPN
app-717	61	21	et	et	PROPN
app-717	61	22	al	al	PROPN
app-717	61	23	.	.	PROPN
app-717	61	24	,	,	PUNCT
app-717	61	25	2024	2024	NUM
app-717	61	26	)	)	PUNCT
app-717	61	27	.	.	PUNCT
app-717	62	1	these	these	DET
app-717	62	2	issues	issue	NOUN
app-717	62	3	led	lead	VERB
app-717	62	4	to	to	ADP
app-717	62	5	misunderstandings	misunderstanding	NOUN
app-717	62	6	about	about	ADP
app-717	62	7	the	the	DET
app-717	62	8	safety	safety	NOUN
app-717	62	9	of	of	ADP
app-717	62	10	hrt	hrt	PROPN
app-717	62	11	,	,	PUNCT
app-717	62	12	resulting	result	VERB
app-717	62	13	in	in	ADP
app-717	62	14	significant	significant	ADJ
app-717	62	15	declines	decline	NOUN
app-717	62	16	in	in	ADP
app-717	62	17	prescribing	prescribing	NOUN
app-717	62	18	,	,	PUNCT
app-717	62	19	even	even	ADV
app-717	62	20	for	for	ADP
app-717	62	21	women	woman	NOUN
app-717	62	22	not	not	PART
app-717	62	23	at	at	ADP
app-717	62	24	significant	significant	ADJ
app-717	62	25	risk	risk	NOUN
app-717	62	26	.	.	PUNCT
app-717	63	1	new	new	ADJ
app-717	63	2	formulations	formulation	NOUN
app-717	63	3	and	and	CCONJ
app-717	63	4	updated	update	VERB
app-717	63	5	research	research	NOUN
app-717	63	6	have	have	AUX
app-717	63	7	clarified	clarify	VERB
app-717	63	8	these	these	DET
app-717	63	9	findings	finding	NOUN
app-717	63	10	,	,	PUNCT
app-717	63	11	highlighting	highlight	VERB
app-717	63	12	the	the	DET
app-717	63	13	significance	significance	NOUN
app-717	63	14	of	of	ADP
app-717	63	15	bio	bio	ADJ
app-717	63	16	-	-	ADJ
app-717	63	17	identical	identical	ADJ
app-717	63	18	progesterone	progesterone	NOUN
app-717	63	19	,	,	PUNCT
app-717	63	20	personalized	personalized	ADJ
app-717	63	21	treatment	treatment	NOUN
app-717	63	22	,	,	PUNCT
app-717	63	23	and	and	CCONJ
app-717	63	24	timing	timing	NOUN
app-717	63	25	in	in	ADP
app-717	63	26	hormone	hormone	NOUN
app-717	63	27	therapy	therapy	NOUN
app-717	63	28	choices	choice	NOUN
app-717	63	29	.	.	PUNCT
app-717	64	1	although	although	SCONJ
app-717	64	2	hrt	hrt	PROPN
app-717	64	3	is	be	AUX
app-717	64	4	safe	safe	ADJ
app-717	64	5	for	for	ADP
app-717	64	6	many	many	ADJ
app-717	64	7	women	woman	NOUN
app-717	64	8	,	,	PUNCT
app-717	64	9	it	it	PRON
app-717	64	10	still	still	ADV
app-717	64	11	poses	pose	VERB
app-717	64	12	certain	certain	ADJ
app-717	64	13	risks	risk	NOUN
app-717	64	14	.	.	PUNCT
app-717	65	1	prolonged	prolonged	ADJ
app-717	65	2	use	use	NOUN
app-717	65	3	can	can	AUX
app-717	65	4	increase	increase	VERB
app-717	65	5	the	the	DET
app-717	65	6	chances	chance	NOUN
app-717	65	7	of	of	ADP
app-717	65	8	breast	breast	NOUN
app-717	65	9	and	and	CCONJ
app-717	65	10	endometrial	endometrial	ADJ
app-717	65	11	cancer	cancer	NOUN
app-717	65	12	,	,	PUNCT
app-717	65	13	blood	blood	NOUN
app-717	65	14	clots	clot	NOUN
app-717	65	15	,	,	PUNCT
app-717	65	16	and	and	CCONJ
app-717	65	17	stroke	stroke	NOUN
app-717	65	18	and	and	CCONJ
app-717	65	19	may	may	AUX
app-717	65	20	impair	impair	VERB
app-717	65	21	cognitive	cognitive	ADJ
app-717	65	22	function	function	NOUN
app-717	65	23	(	(	PUNCT
app-717	65	24	marsden	marsden	PROPN
app-717	65	25	,	,	PUNCT
app-717	65	26	2022	2022	NUM
app-717	65	27	)	)	PUNCT
app-717	65	28	.	.	PUNCT
app-717	66	1	the	the	DET
app-717	66	2	benefits	benefit	NOUN
app-717	66	3	and	and	CCONJ
app-717	66	4	risks	risk	NOUN
app-717	66	5	of	of	ADP
app-717	66	6	taking	take	VERB
app-717	66	7	hrt	hrt	PROPN
app-717	66	8	depend	depend	VERB
app-717	66	9	on	on	ADP
app-717	66	10	an	an	DET
app-717	66	11	individual	individual	NOUN
app-717	66	12	's	's	PART
app-717	66	13	age	age	NOUN
app-717	66	14	,	,	PUNCT
app-717	66	15	menopause	menopause	NOUN
app-717	66	16	stage	stage	NOUN
app-717	66	17	,	,	PUNCT
app-717	66	18	and	and	CCONJ
app-717	66	19	any	any	DET
app-717	66	20	pre	pre	ADJ
app-717	66	21	-	-	ADJ
app-717	66	22	existing	exist	VERB
app-717	66	23	risk	risk	NOUN
app-717	66	24	factors	factor	NOUN
app-717	66	25	they	they	PRON
app-717	66	26	may	may	AUX
app-717	66	27	have	have	VERB
app-717	66	28	.	.	PUNCT
app-717	67	1	the	the	DET
app-717	67	2	aftermath	aftermath	NOUN
app-717	67	3	of	of	ADP
app-717	67	4	the	the	DET
app-717	67	5	whi	whi	NOUN
app-717	67	6	study	study	NOUN
app-717	67	7	has	have	AUX
app-717	67	8	led	lead	VERB
app-717	67	9	to	to	ADP
app-717	67	10	the	the	DET
app-717	67	11	“	"	PUNCT
app-717	67	12	critical	critical	ADJ
app-717	67	13	window	window	NOUN
app-717	67	14	”	"	PUNCT
app-717	67	15	or	or	CCONJ
app-717	67	16	“	"	PUNCT
app-717	67	17	timing	timing	NOUN
app-717	67	18	hypothesis	hypothesis	NOUN
app-717	67	19	,	,	PUNCT
app-717	67	20	”	"	PUNCT
app-717	67	21	which	which	PRON
app-717	67	22	states	state	VERB
app-717	67	23	estrogen	estrogen	NOUN
app-717	67	24	can	can	AUX
app-717	67	25	be	be	AUX
app-717	67	26	neuroprotective	neuroprotective	ADJ
app-717	67	27	only	only	ADV
app-717	67	28	if	if	SCONJ
app-717	67	29	hrt	hrt	PROPN
app-717	67	30	is	be	AUX
app-717	67	31	started	start	VERB
app-717	67	32	shortly	shortly	ADV
app-717	67	33	after	after	ADP
app-717	67	34	the	the	DET
app-717	67	35	onset	onset	NOUN
app-717	67	36	of	of	ADP
app-717	67	37	menopause	menopause	NOUN
app-717	67	38	.	.	PUNCT
app-717	68	1	some	some	DET
app-717	68	2	studies	study	NOUN
app-717	68	3	indicate	indicate	VERB
app-717	68	4	that	that	SCONJ
app-717	68	5	using	use	VERB
app-717	68	6	hrt	hrt	PROPN
app-717	68	7	in	in	ADP
app-717	68	8	the	the	DET
app-717	68	9	early	early	ADJ
app-717	68	10	postmenopausal	postmenopausal	ADJ
app-717	68	11	phase	phase	NOUN
app-717	68	12	is	be	AUX
app-717	68	13	associated	associate	VERB
app-717	68	14	with	with	ADP
app-717	68	15	improved	improved	ADJ
app-717	68	16	well	well	ADV
app-717	68	17	-	-	PUNCT
app-717	68	18	being	being	NOUN
app-717	68	19	,	,	PUNCT
app-717	68	20	while	while	SCONJ
app-717	68	21	its	its	PRON
app-717	68	22	use	use	NOUN
app-717	68	23	at	at	ADP
app-717	68	24	later	late	ADJ
app-717	68	25	stages	stage	NOUN
app-717	68	26	does	do	AUX
app-717	68	27	not	not	PART
app-717	68	28	show	show	VERB
app-717	68	29	the	the	DET
app-717	68	30	same	same	ADJ
app-717	68	31	benefits	benefit	NOUN
app-717	68	32	.	.	PUNCT
app-717	69	1	according	accord	VERB
app-717	69	2	to	to	ADP
app-717	69	3	flores	flores	PROPN
app-717	69	4	et	et	PROPN
app-717	69	5	al	al	PROPN
app-717	69	6	.	.	PROPN
app-717	69	7	(	(	PUNCT
app-717	69	8	2021	2021	NUM
app-717	69	9	)	)	PUNCT
app-717	69	10	,	,	PUNCT
app-717	69	11	hrt	hrt	PROPN
app-717	69	12	is	be	AUX
app-717	69	13	a	a	DET
app-717	69	14	valuable	valuable	ADJ
app-717	69	15	option	option	NOUN
app-717	69	16	for	for	ADP
app-717	69	17	symptomatic	symptomatic	ADJ
app-717	69	18	,	,	PUNCT
app-717	69	19	healthy	healthy	ADJ
app-717	69	20	menopausal	menopausal	ADJ
app-717	69	21	women	woman	NOUN
app-717	69	22	who	who	PRON
app-717	69	23	are	be	AUX
app-717	69	24	under	under	ADP
app-717	69	25	60	60	NUM
app-717	69	26	years	year	NOUN
app-717	69	27	old	old	ADJ
app-717	69	28	and	and	CCONJ
app-717	69	29	have	have	AUX
app-717	69	30	been	be	AUX
app-717	69	31	menopausal	menopausal	ADJ
app-717	69	32	for	for	ADP
app-717	69	33	less	less	ADJ
app-717	69	34	than	than	ADP
app-717	69	35	10	10	NUM
app-717	69	36	years	year	NOUN
app-717	69	37	.	.	PUNCT
app-717	70	1	this	this	PRON
app-717	70	2	applies	apply	VERB
app-717	70	3	as	as	ADV
app-717	70	4	long	long	ADV
app-717	70	5	as	as	SCONJ
app-717	70	6	they	they	PRON
app-717	70	7	do	do	AUX
app-717	70	8	not	not	PART
app-717	70	9	have	have	VERB
app-717	70	10	any	any	DET
app-717	70	11	contraindications	contraindication	NOUN
app-717	70	12	,	,	PUNCT
app-717	70	13	such	such	ADJ
app-717	70	14	as	as	ADP
app-717	70	15	cardiovascular	cardiovascular	ADJ
app-717	70	16	disease	disease	NOUN
app-717	70	17	,	,	PUNCT
app-717	70	18	poorly	poorly	ADV
app-717	70	19	controlled	control	VERB
app-717	70	20	diabetes	diabetes	NOUN
app-717	70	21	,	,	PUNCT
app-717	70	22	or	or	CCONJ
app-717	70	23	high	high	ADJ
app-717	70	24	blood	blood	NOUN
app-717	70	25	pressure	pressure	NOUN
app-717	70	26	,	,	PUNCT
app-717	70	27	as	as	ADV
app-717	70	28	well	well	ADV
app-717	70	29	as	as	ADP
app-717	70	30	no	no	DET
app-717	70	31	risk	risk	NOUN
app-717	70	32	factors	factor	NOUN
app-717	70	33	for	for	ADP
app-717	70	34	venous	venous	ADJ
app-717	70	35	thromboembolism	thromboembolism	NOUN
app-717	70	36	,	,	PUNCT
app-717	70	37	including	include	VERB
app-717	70	38	obesity	obesity	NOUN
app-717	70	39	,	,	PUNCT
app-717	70	40	smoking	smoking	NOUN
app-717	70	41	,	,	PUNCT
app-717	70	42	or	or	CCONJ
app-717	70	43	clotting	clotting	NOUN
app-717	70	44	disorders	disorder	NOUN
app-717	70	45	.	.	PUNCT
app-717	71	1	while	while	SCONJ
app-717	71	2	the	the	DET
app-717	71	3	number	number	NOUN
app-717	71	4	of	of	ADP
app-717	71	5	hormones	hormone	NOUN
app-717	71	6	that	that	PRON
app-717	71	7	shift	shift	VERB
app-717	71	8	during	during	ADP
app-717	71	9	menopause	menopause	NOUN
app-717	71	10	is	be	AUX
app-717	71	11	significant	significant	ADJ
app-717	71	12	,	,	PUNCT
app-717	71	13	only	only	ADV
app-717	71	14	estrogen	estrogen	NOUN
app-717	71	15	and	and	CCONJ
app-717	71	16	progesterone	progesterone	NOUN
app-717	71	17	are	be	AUX
app-717	71	18	used	use	VERB
app-717	71	19	in	in	ADP
app-717	71	20	hrt	hrt	PROPN
app-717	71	21	for	for	ADP
app-717	71	22	this	this	DET
app-717	71	23	cohort	cohort	NOUN
app-717	71	24	.	.	PUNCT
app-717	72	1	estrogen	estrogen	NOUN
app-717	72	2	-	-	PUNCT
app-717	72	3	only	only	ADV
app-717	72	4	formulations	formulation	NOUN
app-717	72	5	for	for	ADP
app-717	72	6	hrt	hrt	PROPN
app-717	72	7	include	include	VERB
app-717	72	8	conjugated	conjugate	VERB
app-717	72	9	equine	equine	NOUN
app-717	72	10	estrogens	estrogen	NOUN
app-717	72	11	,	,	PUNCT
app-717	72	12	17βe2	17βe2	NUM
app-717	72	13	,	,	PUNCT
app-717	72	14	and	and	CCONJ
app-717	72	15	esterified	esterify	VERB
app-717	72	16	estrogens	estrogen	NOUN
app-717	72	17	;	;	PUNCT
app-717	72	18	they	they	PRON
app-717	72	19	are	be	AUX
app-717	72	20	typically	typically	ADV
app-717	72	21	used	use	VERB
app-717	72	22	for	for	ADP
app-717	72	23	women	woman	NOUN
app-717	72	24	without	without	ADP
app-717	72	25	a	a	DET
app-717	72	26	uterus	uterus	NOUN
app-717	72	27	(	(	PUNCT
app-717	72	28	flores	flore	NOUN
app-717	72	29	et	et	PROPN
app-717	72	30	al	al	PROPN
app-717	72	31	.	.	PROPN
app-717	72	32	,	,	PUNCT
app-717	72	33	2021	2021	NUM
app-717	72	34	)	)	PUNCT
app-717	72	35	.	.	PUNCT
app-717	73	1	in	in	ADP
app-717	73	2	addition	addition	NOUN
app-717	73	3	to	to	ADP
app-717	73	4	oral	oral	ADJ
app-717	73	5	routes	route	NOUN
app-717	73	6	of	of	ADP
app-717	73	7	administration	administration	NOUN
app-717	73	8	,	,	PUNCT
app-717	73	9	estrogen	estrogen	NOUN
app-717	73	10	-	-	PUNCT
app-717	73	11	only	only	ADV
app-717	73	12	formulations	formulation	NOUN
app-717	73	13	such	such	ADJ
app-717	73	14	as	as	ADP
app-717	73	15	injection	injection	NOUN
app-717	73	16	,	,	PUNCT
app-717	73	17	subdermal	subdermal	ADJ
app-717	73	18	implant	implant	NOUN
app-717	73	19	,	,	PUNCT
app-717	73	20	and	and	CCONJ
app-717	73	21	transdermal	transdermal	ADJ
app-717	73	22	formulations	formulation	NOUN
app-717	73	23	are	be	AUX
app-717	73	24	available	available	ADJ
app-717	73	25	.	.	PUNCT
app-717	74	1	56	56	NUM
app-717	74	2	progesterone	progesterone	NOUN
app-717	74	3	can	can	AUX
app-717	74	4	be	be	AUX
app-717	74	5	used	use	VERB
app-717	74	6	alone	alone	ADJ
app-717	74	7	or	or	CCONJ
app-717	74	8	in	in	ADP
app-717	74	9	combination	combination	NOUN
app-717	74	10	with	with	ADP
app-717	74	11	estrogen	estrogen	NOUN
app-717	74	12	.	.	PUNCT
app-717	75	1	available	available	ADJ
app-717	75	2	routes	route	NOUN
app-717	75	3	of	of	ADP
app-717	75	4	administration	administration	NOUN
app-717	75	5	include	include	VERB
app-717	75	6	oral	oral	ADJ
app-717	75	7	,	,	PUNCT
app-717	75	8	injection	injection	NOUN
app-717	75	9	,	,	PUNCT
app-717	75	10	implants	implant	NOUN
app-717	75	11	,	,	PUNCT
app-717	75	12	transdermal	transdermal	ADJ
app-717	75	13	(	(	PUNCT
app-717	75	14	via	via	ADP
app-717	75	15	vaginal	vaginal	ADJ
app-717	75	16	application	application	NOUN
app-717	75	17	)	)	PUNCT
app-717	75	18	,	,	PUNCT
app-717	75	19	and	and	CCONJ
app-717	75	20	intrauterine	intrauterine	ADJ
app-717	75	21	systems	system	NOUN
app-717	75	22	.	.	PUNCT
app-717	76	1	formulations	formulation	NOUN
app-717	76	2	containing	contain	VERB
app-717	76	3	progesterone	progesterone	NOUN
app-717	76	4	are	be	AUX
app-717	76	5	used	use	VERB
app-717	76	6	more	more	ADV
app-717	76	7	commonly	commonly	ADV
app-717	76	8	in	in	ADP
app-717	76	9	women	woman	NOUN
app-717	76	10	with	with	ADP
app-717	76	11	a	a	DET
app-717	76	12	uterus	uterus	NOUN
app-717	76	13	.	.	PUNCT
app-717	77	1	selective	selective	ADJ
app-717	77	2	estrogen	estrogen	NOUN
app-717	77	3	receptor	receptor	NOUN
app-717	77	4	modulators	modulator	NOUN
app-717	77	5	are	be	AUX
app-717	77	6	a	a	DET
app-717	77	7	newer	new	ADJ
app-717	77	8	treatment	treatment	NOUN
app-717	77	9	option	option	NOUN
app-717	77	10	that	that	PRON
app-717	77	11	targets	target	VERB
app-717	77	12	specific	specific	ADJ
app-717	77	13	estrogen	estrogen	NOUN
app-717	77	14	receptors	receptor	NOUN
app-717	77	15	to	to	PART
app-717	77	16	exert	exert	VERB
app-717	77	17	agonist	agonist	NOUN
app-717	77	18	or	or	CCONJ
app-717	77	19	antagonist	antagonist	NOUN
app-717	77	20	actions	action	NOUN
app-717	77	21	on	on	ADP
app-717	77	22	the	the	DET
app-717	77	23	estrogen	estrogen	NOUN
app-717	77	24	receptors	receptor	NOUN
app-717	77	25	in	in	ADP
app-717	77	26	various	various	ADJ
app-717	77	27	estrogen	estrogen	NOUN
app-717	77	28	-	-	PUNCT
app-717	77	29	target	target	NOUN
app-717	77	30	tissues	tissue	NOUN
app-717	77	31	(	(	PUNCT
app-717	77	32	flores	flore	NOUN
app-717	77	33	et	et	PROPN
app-717	77	34	al	al	PROPN
app-717	77	35	.	.	PROPN
app-717	77	36	,	,	PUNCT
app-717	77	37	2021	2021	NUM
app-717	77	38	)	)	PUNCT
app-717	77	39	.	.	PUNCT
app-717	78	1	women	woman	NOUN
app-717	78	2	randomized	randomize	VERB
app-717	78	3	to	to	ADP
app-717	78	4	oral	oral	ADJ
app-717	78	5	estrogen	estrogen	NOUN
app-717	78	6	in	in	ADP
app-717	78	7	the	the	DET
app-717	78	8	kronos	kronos	PROPN
app-717	78	9	early	early	ADJ
app-717	78	10	estrogen	estrogen	NOUN
app-717	78	11	prevention	prevention	NOUN
app-717	78	12	cognitive	cognitive	ADJ
app-717	78	13	and	and	CCONJ
app-717	78	14	affective	affective	ADJ
app-717	78	15	ancillary	ancillary	ADJ
app-717	78	16	study	study	NOUN
app-717	78	17	showed	show	VERB
app-717	78	18	greater	great	ADJ
app-717	78	19	benefit	benefit	NOUN
app-717	78	20	on	on	ADP
app-717	78	21	affective	affective	ADJ
app-717	78	22	mood	mood	NOUN
app-717	78	23	states	state	NOUN
app-717	78	24	than	than	SCONJ
app-717	78	25	women	woman	NOUN
app-717	78	26	randomized	randomize	VERB
app-717	78	27	to	to	ADP
app-717	78	28	transdermal	transdermal	ADJ
app-717	78	29	17β	17β	NOUN
app-717	78	30	-	-	PUNCT
app-717	78	31	estradiol	estradiol	PROPN
app-717	78	32	or	or	CCONJ
app-717	78	33	placebo	placebo	NOUN
app-717	78	34	(	(	PUNCT
app-717	78	35	raz	raz	NOUN
app-717	78	36	et	et	PROPN
app-717	78	37	al	al	PROPN
app-717	78	38	.	.	PROPN
app-717	78	39	,	,	PUNCT
app-717	78	40	2016	2016	NUM
app-717	78	41	)	)	PUNCT
app-717	78	42	.	.	PUNCT
app-717	79	1	however	however	ADV
app-717	79	2	,	,	PUNCT
app-717	79	3	after	after	ADP
app-717	79	4	a	a	DET
app-717	79	5	systematic	systematic	ADJ
app-717	79	6	review	review	NOUN
app-717	79	7	of	of	ADP
app-717	79	8	the	the	DET
app-717	79	9	literature	literature	NOUN
app-717	79	10	comparing	compare	VERB
app-717	79	11	the	the	DET
app-717	79	12	transdermal	transdermal	ADJ
app-717	79	13	and	and	CCONJ
app-717	79	14	oral	oral	ADJ
app-717	79	15	administration	administration	NOUN
app-717	79	16	routes	route	NOUN
app-717	79	17	of	of	ADP
app-717	79	18	estrogens	estrogen	NOUN
app-717	79	19	for	for	ADP
app-717	79	20	menopausal	menopausal	ADJ
app-717	79	21	women	woman	NOUN
app-717	79	22	,	,	PUNCT
app-717	79	23	goldštajn	goldštajn	PROPN
app-717	79	24	et	et	PROPN
app-717	79	25	al	al	PROPN
app-717	79	26	.	.	PROPN
app-717	79	27	(	(	PUNCT
app-717	79	28	2023	2023	NUM
app-717	79	29	)	)	PUNCT
app-717	79	30	determined	determine	VERB
app-717	79	31	that	that	SCONJ
app-717	79	32	available	available	ADJ
app-717	79	33	evidence	evidence	NOUN
app-717	79	34	is	be	AUX
app-717	79	35	limited	limited	ADJ
app-717	79	36	and	and	CCONJ
app-717	79	37	low	low	ADJ
app-717	79	38	quality	quality	NOUN
app-717	79	39	.	.	PUNCT
app-717	80	1	the	the	DET
app-717	80	2	authors	author	NOUN
app-717	80	3	indicate	indicate	VERB
app-717	80	4	that	that	SCONJ
app-717	80	5	until	until	SCONJ
app-717	80	6	more	more	ADJ
app-717	80	7	research	research	NOUN
app-717	80	8	is	be	AUX
app-717	80	9	available	available	ADJ
app-717	80	10	,	,	PUNCT
app-717	80	11	the	the	DET
app-717	80	12	main	main	ADJ
app-717	80	13	clinical	clinical	ADJ
app-717	80	14	difference	difference	NOUN
app-717	80	15	between	between	ADP
app-717	80	16	the	the	DET
app-717	80	17	two	two	NUM
app-717	80	18	administration	administration	NOUN
app-717	80	19	routes	route	NOUN
app-717	80	20	is	be	AUX
app-717	80	21	the	the	DET
app-717	80	22	reduced	reduce	VERB
app-717	80	23	risk	risk	NOUN
app-717	80	24	of	of	ADP
app-717	80	25	venous	venous	ADJ
app-717	80	26	thromboembolism	thromboembolism	NOUN
app-717	80	27	,	,	PUNCT
app-717	80	28	which	which	PRON
app-717	80	29	suggests	suggest	VERB
app-717	80	30	that	that	SCONJ
app-717	80	31	transdermal	transdermal	ADJ
app-717	80	32	hrt	hrt	PROPN
app-717	80	33	is	be	AUX
app-717	80	34	safer	safe	ADJ
app-717	80	35	than	than	ADP
app-717	80	36	the	the	DET
app-717	80	37	oral	oral	ADJ
app-717	80	38	administration	administration	NOUN
app-717	80	39	route	route	NOUN
app-717	80	40	.	.	PUNCT
app-717	81	1	perceived	perceive	VERB
app-717	81	2	and	and	CCONJ
app-717	81	3	actual	actual	ADJ
app-717	81	4	risk	risk	NOUN
app-717	81	5	factors	factor	NOUN
app-717	81	6	of	of	ADP
app-717	81	7	hrt	hrt	PROPN
app-717	81	8	similarly	similarly	ADV
app-717	81	9	,	,	PUNCT
app-717	81	10	like	like	ADP
app-717	81	11	all	all	DET
app-717	81	12	pharmaceutical	pharmaceutical	ADJ
app-717	81	13	interventions	intervention	NOUN
app-717	81	14	,	,	PUNCT
app-717	81	15	hrt	hrt	PROPN
app-717	81	16	is	be	AUX
app-717	81	17	not	not	PART
app-717	81	18	without	without	ADP
app-717	81	19	risk	risk	NOUN
app-717	81	20	.	.	PUNCT
app-717	82	1	depending	depend	VERB
app-717	82	2	on	on	ADP
app-717	82	3	formulation	formulation	NOUN
app-717	82	4	and	and	CCONJ
app-717	82	5	individual	individual	ADJ
app-717	82	6	patient	patient	NOUN
app-717	82	7	profile	profile	NOUN
app-717	82	8	,	,	PUNCT
app-717	82	9	physical	physical	ADJ
app-717	82	10	risks	risk	NOUN
app-717	82	11	include	include	VERB
app-717	82	12	increased	increase	VERB
app-717	82	13	prevalence	prevalence	NOUN
app-717	82	14	of	of	ADP
app-717	82	15	breast	breast	NOUN
app-717	82	16	and	and	CCONJ
app-717	82	17	uterine	uterine	ADJ
app-717	82	18	cancer	cancer	NOUN
app-717	82	19	,	,	PUNCT
app-717	82	20	cardiovascular	cardiovascular	ADJ
app-717	82	21	disease	disease	NOUN
app-717	82	22	,	,	PUNCT
app-717	82	23	gallbladder	gallbladder	NOUN
app-717	82	24	disease	disease	NOUN
app-717	82	25	,	,	PUNCT
app-717	82	26	and	and	CCONJ
app-717	82	27	urinary	urinary	ADJ
app-717	82	28	incontinence	incontinence	NOUN
app-717	82	29	.	.	PUNCT
app-717	83	1	while	while	SCONJ
app-717	83	2	research	research	NOUN
app-717	83	3	does	do	AUX
app-717	83	4	not	not	PART
app-717	83	5	indicate	indicate	VERB
app-717	83	6	that	that	SCONJ
app-717	83	7	hrt	hrt	PROPN
app-717	83	8	directly	directly	ADV
app-717	83	9	decreases	decrease	VERB
app-717	83	10	emotional	emotional	ADJ
app-717	83	11	well	well	ADV
app-717	83	12	-	-	PUNCT
app-717	83	13	being	being	NOUN
app-717	83	14	,	,	PUNCT
app-717	83	15	there	there	PRON
app-717	83	16	may	may	AUX
app-717	83	17	be	be	AUX
app-717	83	18	indirect	indirect	ADJ
app-717	83	19	risk	risk	NOUN
app-717	83	20	.	.	PUNCT
app-717	84	1	even	even	ADV
app-717	84	2	in	in	ADP
app-717	84	3	the	the	DET
app-717	84	4	absence	absence	NOUN
app-717	84	5	of	of	ADP
app-717	84	6	physical	physical	ADJ
app-717	84	7	risk	risk	NOUN
app-717	84	8	factors	factor	NOUN
app-717	84	9	,	,	PUNCT
app-717	84	10	there	there	PRON
app-717	84	11	is	be	VERB
app-717	84	12	the	the	DET
app-717	84	13	possibility	possibility	NOUN
app-717	84	14	of	of	ADP
app-717	84	15	a	a	DET
app-717	84	16	toll	toll	NOUN
app-717	84	17	on	on	ADP
app-717	84	18	mental	mental	ADJ
app-717	84	19	health	health	NOUN
app-717	84	20	.	.	PUNCT
app-717	85	1	hearing	hear	VERB
app-717	85	2	about	about	ADP
app-717	85	3	others	other	NOUN
app-717	85	4	experiencing	experience	VERB
app-717	85	5	negative	negative	ADJ
app-717	85	6	outcomes	outcome	NOUN
app-717	85	7	can	can	AUX
app-717	85	8	amplify	amplify	VERB
app-717	85	9	concerns	concern	NOUN
app-717	85	10	and	and	CCONJ
app-717	85	11	lead	lead	VERB
app-717	85	12	to	to	ADP
app-717	85	13	anxiety	anxiety	NOUN
app-717	85	14	or	or	CCONJ
app-717	85	15	worsening	worsen	VERB
app-717	85	16	mental	mental	ADJ
app-717	85	17	health	health	NOUN
app-717	85	18	.	.	PUNCT
app-717	86	1	according	accord	VERB
app-717	86	2	to	to	ADP
app-717	86	3	bagarić	bagarić	PROPN
app-717	86	4	et	et	PROPN
app-717	86	5	al	al	PROPN
app-717	86	6	.	.	PROPN
app-717	87	1	(	(	PUNCT
app-717	87	2	2022	2022	NUM
app-717	87	3	)	)	PUNCT
app-717	87	4	,	,	PUNCT
app-717	87	5	the	the	DET
app-717	87	6	phenomenon	phenomenon	NOUN
app-717	87	7	known	know	VERB
app-717	87	8	as	as	ADP
app-717	87	9	the	the	DET
app-717	87	10	vicarious	vicarious	ADJ
app-717	87	11	nocebo	nocebo	NOUN
app-717	87	12	effect	effect	NOUN
app-717	87	13	refers	refer	VERB
app-717	87	14	to	to	ADP
app-717	87	15	the	the	DET
app-717	87	16	psychological	psychological	ADJ
app-717	87	17	impact	impact	NOUN
app-717	87	18	of	of	ADP
app-717	87	19	learning	learn	VERB
app-717	87	20	about	about	ADP
app-717	87	21	the	the	DET
app-717	87	22	adverse	adverse	ADJ
app-717	87	23	effects	effect	NOUN
app-717	87	24	experienced	experience	VERB
app-717	87	25	by	by	ADP
app-717	87	26	others	other	NOUN
app-717	87	27	who	who	PRON
app-717	87	28	are	be	AUX
app-717	87	29	using	use	VERB
app-717	87	30	the	the	DET
app-717	87	31	same	same	ADJ
app-717	87	32	medical	medical	ADJ
app-717	87	33	intervention	intervention	NOUN
app-717	87	34	.	.	PUNCT
app-717	88	1	this	this	PRON
app-717	88	2	may	may	AUX
app-717	88	3	decrease	decrease	VERB
app-717	88	4	as	as	ADP
app-717	88	5	erroneous	erroneous	ADJ
app-717	88	6	media	medium	NOUN
app-717	88	7	reports	report	NOUN
app-717	88	8	about	about	ADP
app-717	88	9	the	the	DET
app-717	88	10	whi	whi	NOUN
app-717	88	11	study	study	NOUN
app-717	88	12	claiming	claim	VERB
app-717	88	13	that	that	SCONJ
app-717	88	14	hormone	hormone	NOUN
app-717	88	15	therapy	therapy	NOUN
app-717	88	16	causes	cause	VERB
app-717	88	17	breast	breast	NOUN
app-717	88	18	cancer	cancer	NOUN
app-717	88	19	and	and	CCONJ
app-717	88	20	cardiovascular	cardiovascular	ADJ
app-717	88	21	disease	disease	NOUN
app-717	88	22	fade	fade	NOUN
app-717	88	23	from	from	ADP
app-717	88	24	the	the	DET
app-717	88	25	memories	memory	NOUN
app-717	88	26	of	of	ADP
app-717	88	27	healthcare	healthcare	NOUN
app-717	88	28	providers	provider	NOUN
app-717	88	29	and	and	CCONJ
app-717	88	30	the	the	DET
app-717	88	31	general	general	ADJ
app-717	88	32	public	public	NOUN
app-717	88	33	.	.	PUNCT
app-717	89	1	emerging	emerge	VERB
app-717	89	2	research	research	NOUN
app-717	89	3	on	on	ADP
app-717	89	4	hrt	hrt	PROPN
app-717	89	5	’s	’s	PART
app-717	89	6	role	role	NOUN
app-717	89	7	in	in	ADP
app-717	89	8	inflammatory	inflammatory	ADJ
app-717	89	9	pathways	pathway	NOUN
app-717	89	10	in	in	ADP
app-717	89	11	recent	recent	ADJ
app-717	89	12	years	year	NOUN
app-717	89	13	,	,	PUNCT
app-717	89	14	researchers	researcher	NOUN
app-717	89	15	have	have	AUX
app-717	89	16	hypothesized	hypothesize	VERB
app-717	89	17	that	that	SCONJ
app-717	89	18	mood	mood	NOUN
app-717	89	19	disorders	disorder	NOUN
app-717	89	20	may	may	AUX
app-717	89	21	result	result	VERB
app-717	89	22	from	from	ADP
app-717	89	23	an	an	DET
app-717	89	24	inflammatory	inflammatory	ADJ
app-717	89	25	response	response	NOUN
app-717	89	26	.	.	PUNCT
app-717	90	1	evidence	evidence	NOUN
app-717	90	2	supporting	support	VERB
app-717	90	3	this	this	DET
app-717	90	4	hypothesis	hypothesis	NOUN
app-717	90	5	was	be	AUX
app-717	90	6	presented	present	VERB
app-717	90	7	by	by	ADP
app-717	90	8	ye	ye	PRON
app-717	90	9	et	et	PROPN
app-717	90	10	al	al	PROPN
app-717	90	11	.	.	PROPN
app-717	91	1	(	(	PUNCT
app-717	91	2	2023	2023	NUM
app-717	91	3	)	)	PUNCT
app-717	91	4	,	,	PUNCT
app-717	91	5	who	who	PRON
app-717	91	6	identified	identify	VERB
app-717	91	7	low	low	ADJ
app-717	91	8	-	-	PUNCT
app-717	91	9	grade	grade	NOUN
app-717	91	10	systemic	systemic	ADJ
app-717	91	11	inflammation	inflammation	NOUN
app-717	91	12	in	in	ADP
app-717	91	13	patients	patient	NOUN
app-717	91	14	with	with	ADP
app-717	91	15	depression	depression	NOUN
app-717	91	16	.	.	PUNCT
app-717	92	1	their	their	PRON
app-717	92	2	findings	finding	NOUN
app-717	92	3	included	include	VERB
app-717	92	4	elevated	elevated	ADJ
app-717	92	5	concentrations	concentration	NOUN
app-717	92	6	of	of	ADP
app-717	92	7	c	c	NOUN
app-717	92	8	-	-	PUNCT
app-717	92	9	reactive	reactive	ADJ
app-717	92	10	protein	protein	NOUN
app-717	92	11	in	in	ADP
app-717	92	12	21	21	NUM
app-717	92	13	%	%	NOUN
app-717	92	14	to	to	PART
app-717	92	15	34	34	NUM
app-717	92	16	%	%	NOUN
app-717	92	17	of	of	ADP
app-717	92	18	patients	patient	NOUN
app-717	92	19	,	,	PUNCT
app-717	92	20	as	as	ADV
app-717	92	21	well	well	ADV
app-717	92	22	as	as	ADP
app-717	92	23	increased	increase	VERB
app-717	92	24	levels	level	NOUN
app-717	92	25	of	of	ADP
app-717	92	26	interleukin-6	interleukin-6	PROPN
app-717	92	27	(	(	PUNCT
app-717	92	28	il-6	il-6	NUM
app-717	92	29	)	)	PUNCT
app-717	92	30	and	and	CCONJ
app-717	92	31	other	other	ADJ
app-717	92	32	inflammatory	inflammatory	ADJ
app-717	92	33	cytokines	cytokine	NOUN
app-717	92	34	in	in	ADP
app-717	92	35	both	both	CCONJ
app-717	92	36	blood	blood	NOUN
app-717	92	37	and	and	CCONJ
app-717	92	38	cerebrospinal	cerebrospinal	ADJ
app-717	92	39	fluid	fluid	NOUN
app-717	92	40	.	.	PUNCT
app-717	93	1	this	this	DET
app-717	93	2	inflammatory	inflammatory	ADJ
app-717	93	3	activity	activity	NOUN
app-717	93	4	is	be	AUX
app-717	93	5	believed	believe	VERB
app-717	93	6	to	to	PART
app-717	93	7	impact	impact	VERB
app-717	93	8	neural	neural	ADJ
app-717	93	9	circuits	circuit	NOUN
app-717	93	10	in	in	ADP
app-717	93	11	the	the	DET
app-717	93	12	brain	brain	NOUN
app-717	93	13	related	relate	VERB
app-717	93	14	to	to	ADP
app-717	93	15	mood	mood	NOUN
app-717	93	16	regulation	regulation	NOUN
app-717	93	17	,	,	PUNCT
app-717	93	18	such	such	ADJ
app-717	93	19	as	as	ADP
app-717	93	20	the	the	DET
app-717	93	21	hippocampus	hippocampus	NOUN
app-717	93	22	and	and	CCONJ
app-717	93	23	the	the	DET
app-717	93	24	prefrontal	prefrontal	ADJ
app-717	93	25	cortex	cortex	NOUN
app-717	93	26	(	(	PUNCT
app-717	93	27	ye	ye	NOUN
app-717	93	28	et	et	NOUN
app-717	93	29	al	al	PROPN
app-717	93	30	.	.	PROPN
app-717	93	31	,	,	PUNCT
app-717	93	32	2023	2023	NUM
app-717	93	33	)	)	PUNCT
app-717	93	34	.	.	PUNCT
app-717	94	1	autoimmune	autoimmune	ADJ
app-717	94	2	diseases	disease	NOUN
app-717	94	3	often	often	ADV
app-717	94	4	worsen	worsen	VERB
app-717	94	5	during	during	ADP
app-717	94	6	menopause	menopause	NOUN
app-717	94	7	due	due	ADP
app-717	94	8	to	to	ADP
app-717	94	9	increased	increase	VERB
app-717	94	10	inflammation	inflammation	NOUN
app-717	94	11	,	,	PUNCT
app-717	94	12	highlighting	highlight	VERB
app-717	94	13	the	the	DET
app-717	94	14	complex	complex	ADJ
app-717	94	15	interplay	interplay	NOUN
app-717	94	16	between	between	ADP
app-717	94	17	physical	physical	ADJ
app-717	94	18	health	health	NOUN
app-717	94	19	and	and	CCONJ
app-717	94	20	mood	mood	NOUN
app-717	94	21	disorders	disorder	NOUN
app-717	94	22	during	during	ADP
app-717	94	23	this	this	DET
app-717	94	24	57	57	NUM
app-717	94	25	transition	transition	NOUN
app-717	94	26	.	.	PUNCT
app-717	95	1	these	these	DET
app-717	95	2	links	link	NOUN
app-717	95	3	suggest	suggest	VERB
app-717	95	4	that	that	SCONJ
app-717	95	5	targeting	target	VERB
app-717	95	6	inflammation	inflammation	NOUN
app-717	95	7	could	could	AUX
app-717	95	8	be	be	AUX
app-717	95	9	a	a	DET
app-717	95	10	viable	viable	ADJ
app-717	95	11	approach	approach	NOUN
app-717	95	12	to	to	ADP
app-717	95	13	managing	manage	VERB
app-717	95	14	mental	mental	ADJ
app-717	95	15	health	health	NOUN
app-717	95	16	symptoms	symptom	NOUN
app-717	95	17	.	.	PUNCT
app-717	96	1	hrt	hrt	PROPN
app-717	96	2	,	,	PUNCT
app-717	96	3	particularly	particularly	ADV
app-717	96	4	estrogen	estrogen	NOUN
app-717	96	5	-	-	PUNCT
app-717	96	6	based	base	VERB
app-717	96	7	therapies	therapy	NOUN
app-717	96	8	,	,	PUNCT
app-717	96	9	may	may	AUX
app-717	96	10	help	help	AUX
app-717	96	11	modulate	modulate	VERB
app-717	96	12	inflammatory	inflammatory	ADJ
app-717	96	13	responses	response	NOUN
app-717	96	14	in	in	ADP
app-717	96	15	menopausal	menopausal	ADJ
app-717	96	16	women	woman	NOUN
app-717	96	17	.	.	PUNCT
app-717	97	1	estrogen	estrogen	PROPN
app-717	97	2	has	have	VERB
app-717	97	3	anti	anti	ADJ
app-717	97	4	-	-	ADJ
app-717	97	5	inflammatory	inflammatory	ADJ
app-717	97	6	properties	property	NOUN
app-717	97	7	that	that	PRON
app-717	97	8	can	can	AUX
app-717	97	9	reduce	reduce	VERB
app-717	97	10	levels	level	NOUN
app-717	97	11	of	of	ADP
app-717	97	12	proinflammatory	proinflammatory	ADJ
app-717	97	13	cytokines	cytokine	NOUN
app-717	97	14	like	like	ADP
app-717	97	15	il-6	il-6	PRON
app-717	97	16	.	.	PUNCT
app-717	98	1	by	by	ADP
app-717	98	2	potentially	potentially	ADV
app-717	98	3	lowering	lower	VERB
app-717	98	4	systemic	systemic	ADJ
app-717	98	5	inflammation	inflammation	NOUN
app-717	98	6	,	,	PUNCT
app-717	98	7	hrt	hrt	PROPN
app-717	98	8	could	could	AUX
app-717	98	9	alleviate	alleviate	VERB
app-717	98	10	some	some	PRON
app-717	98	11	of	of	ADP
app-717	98	12	the	the	DET
app-717	98	13	depressive	depressive	ADJ
app-717	98	14	and	and	CCONJ
app-717	98	15	anxiety	anxiety	NOUN
app-717	98	16	symptoms	symptom	NOUN
app-717	98	17	that	that	PRON
app-717	98	18	are	be	AUX
app-717	98	19	exacerbated	exacerbate	VERB
app-717	98	20	by	by	ADP
app-717	98	21	these	these	DET
app-717	98	22	inflammatory	inflammatory	ADJ
app-717	98	23	processes	process	NOUN
app-717	98	24	.	.	PUNCT
app-717	99	1	slavich	slavich	PROPN
app-717	99	2	and	and	CCONJ
app-717	99	3	sacher	sacher	PROPN
app-717	99	4	(	(	PUNCT
app-717	99	5	2019	2019	NUM
app-717	99	6	)	)	PUNCT
app-717	99	7	describe	describe	VERB
app-717	99	8	how	how	SCONJ
app-717	99	9	estrogen	estrogen	NOUN
app-717	99	10	modulates	modulate	VERB
app-717	99	11	the	the	DET
app-717	99	12	hypothalamicpituitary	hypothalamicpituitary	ADJ
app-717	99	13	-	-	PUNCT
app-717	99	14	adrenal	adrenal	ADJ
app-717	99	15	(	(	PUNCT
app-717	99	16	hpa	hpa	NOUN
app-717	99	17	)	)	PUNCT
app-717	99	18	axis	axis	NOUN
app-717	99	19	and	and	CCONJ
app-717	99	20	its	its	PRON
app-717	99	21	implications	implication	NOUN
app-717	99	22	for	for	ADP
app-717	99	23	stress	stress	NOUN
app-717	99	24	-	-	PUNCT
app-717	99	25	related	relate	VERB
app-717	99	26	disorders	disorder	NOUN
app-717	99	27	.	.	PUNCT
app-717	100	1	researchers	researcher	NOUN
app-717	100	2	note	note	VERB
app-717	100	3	that	that	SCONJ
app-717	100	4	estrogen	estrogen	NOUN
app-717	100	5	can	can	AUX
app-717	100	6	attenuate	attenuate	VERB
app-717	100	7	hpa	hpa	NOUN
app-717	100	8	axis	axis	NOUN
app-717	100	9	responses	response	NOUN
app-717	100	10	to	to	ADP
app-717	100	11	stress	stress	NOUN
app-717	100	12	,	,	PUNCT
app-717	100	13	which	which	PRON
app-717	100	14	may	may	AUX
app-717	100	15	be	be	AUX
app-717	100	16	beneficial	beneficial	ADJ
app-717	100	17	in	in	ADP
app-717	100	18	reducing	reduce	VERB
app-717	100	19	anxiety	anxiety	NOUN
app-717	100	20	and	and	CCONJ
app-717	100	21	depression	depression	NOUN
app-717	100	22	symptoms	symptom	NOUN
app-717	100	23	(	(	PUNCT
app-717	100	24	slavich	slavich	PROPN
app-717	100	25	&	&	CCONJ
app-717	100	26	sacher	sacher	PROPN
app-717	100	27	,	,	PUNCT
app-717	100	28	2019	2019	NUM
app-717	100	29	)	)	PUNCT
app-717	100	30	.	.	PUNCT
app-717	101	1	these	these	DET
app-717	101	2	findings	finding	NOUN
app-717	101	3	suggest	suggest	VERB
app-717	101	4	a	a	DET
app-717	101	5	promising	promising	ADJ
app-717	101	6	role	role	NOUN
app-717	101	7	for	for	ADP
app-717	101	8	hrt	hrt	PROPN
app-717	101	9	not	not	PART
app-717	101	10	only	only	ADV
app-717	101	11	in	in	ADP
app-717	101	12	alleviating	alleviate	VERB
app-717	101	13	physical	physical	ADJ
app-717	101	14	symptoms	symptom	NOUN
app-717	101	15	of	of	ADP
app-717	101	16	menopause	menopause	NOUN
app-717	101	17	but	but	CCONJ
app-717	101	18	also	also	ADV
app-717	101	19	in	in	ADP
app-717	101	20	addressing	address	VERB
app-717	101	21	the	the	DET
app-717	101	22	neuroinflammatory	neuroinflammatory	ADJ
app-717	101	23	mechanisms	mechanism	NOUN
app-717	101	24	that	that	PRON
app-717	101	25	contribute	contribute	VERB
app-717	101	26	to	to	ADP
app-717	101	27	mood	mood	NOUN
app-717	101	28	disorders	disorder	NOUN
app-717	101	29	.	.	PUNCT
app-717	102	1	while	while	SCONJ
app-717	102	2	these	these	DET
app-717	102	3	studies	study	NOUN
app-717	102	4	are	be	AUX
app-717	102	5	promising	promise	VERB
app-717	102	6	,	,	PUNCT
app-717	102	7	they	they	PRON
app-717	102	8	are	be	AUX
app-717	102	9	limited	limit	VERB
app-717	102	10	in	in	ADP
app-717	102	11	scope	scope	NOUN
app-717	102	12	,	,	PUNCT
app-717	102	13	and	and	CCONJ
app-717	102	14	more	more	ADJ
app-717	102	15	research	research	NOUN
app-717	102	16	is	be	AUX
app-717	102	17	needed	need	VERB
app-717	102	18	to	to	PART
app-717	102	19	determine	determine	VERB
app-717	102	20	the	the	DET
app-717	102	21	underlying	underlie	VERB
app-717	102	22	mechanisms	mechanism	NOUN
app-717	102	23	of	of	ADP
app-717	102	24	hrt	hrt	PROPN
app-717	102	25	in	in	ADP
app-717	102	26	relation	relation	NOUN
app-717	102	27	to	to	ADP
app-717	102	28	inflammation	inflammation	NOUN
app-717	102	29	-	-	PUNCT
app-717	102	30	related	relate	VERB
app-717	102	31	mental	mental	ADJ
app-717	102	32	health	health	NOUN
app-717	102	33	outcomes	outcome	NOUN
app-717	102	34	.	.	PUNCT
app-717	103	1	large	large	ADJ
app-717	103	2	-	-	PUNCT
app-717	103	3	scale	scale	NOUN
app-717	103	4	,	,	PUNCT
app-717	103	5	randomized	randomize	VERB
app-717	103	6	controlled	control	VERB
app-717	103	7	trials	trial	NOUN
app-717	103	8	are	be	AUX
app-717	103	9	necessary	necessary	ADJ
app-717	103	10	to	to	PART
app-717	103	11	confirm	confirm	VERB
app-717	103	12	conclusions	conclusion	NOUN
app-717	103	13	and	and	CCONJ
app-717	103	14	identify	identify	VERB
app-717	103	15	the	the	DET
app-717	103	16	most	most	ADV
app-717	103	17	effective	effective	ADJ
app-717	103	18	treatment	treatment	NOUN
app-717	103	19	protocols	protocol	NOUN
app-717	103	20	.	.	PUNCT
app-717	104	1	conclusion	conclusion	NOUN
app-717	104	2	given	give	VERB
app-717	104	3	the	the	DET
app-717	104	4	complex	complex	ADJ
app-717	104	5	interplay	interplay	NOUN
app-717	104	6	between	between	ADP
app-717	104	7	hormones	hormone	NOUN
app-717	104	8	and	and	CCONJ
app-717	104	9	mental	mental	ADJ
app-717	104	10	health	health	NOUN
app-717	104	11	,	,	PUNCT
app-717	104	12	there	there	PRON
app-717	104	13	is	be	VERB
app-717	104	14	a	a	DET
app-717	104	15	need	need	NOUN
app-717	104	16	for	for	ADP
app-717	104	17	personalized	personalized	ADJ
app-717	104	18	treatment	treatment	NOUN
app-717	104	19	approaches	approach	NOUN
app-717	104	20	when	when	SCONJ
app-717	104	21	it	it	PRON
app-717	104	22	comes	come	VERB
app-717	104	23	to	to	ADP
app-717	104	24	treatment	treatment	NOUN
app-717	104	25	.	.	PUNCT
app-717	105	1	there	there	PRON
app-717	105	2	is	be	VERB
app-717	105	3	an	an	DET
app-717	105	4	understanding	understanding	NOUN
app-717	105	5	that	that	SCONJ
app-717	105	6	hrt	hrt	PROPN
app-717	105	7	may	may	AUX
app-717	105	8	mitigate	mitigate	VERB
app-717	105	9	mood	mood	NOUN
app-717	105	10	disorders	disorder	NOUN
app-717	105	11	.	.	PUNCT
app-717	106	1	however	however	ADV
app-717	106	2	,	,	PUNCT
app-717	106	3	it	it	PRON
app-717	106	4	may	may	AUX
app-717	106	5	be	be	AUX
app-717	106	6	most	most	ADV
app-717	106	7	efficacious	efficacious	ADJ
app-717	106	8	for	for	ADP
app-717	106	9	a	a	DET
app-717	106	10	narrow	narrow	ADJ
app-717	106	11	subset	subset	NOUN
app-717	106	12	of	of	ADP
app-717	106	13	individuals	individual	NOUN
app-717	106	14	during	during	ADP
app-717	106	15	a	a	DET
app-717	106	16	specific	specific	ADJ
app-717	106	17	stage	stage	NOUN
app-717	106	18	of	of	ADP
app-717	106	19	menopause	menopause	NOUN
app-717	106	20	or	or	CCONJ
app-717	106	21	used	use	VERB
app-717	106	22	in	in	ADP
app-717	106	23	conjunction	conjunction	NOUN
app-717	106	24	with	with	ADP
app-717	106	25	antidepressants	antidepressant	NOUN
app-717	106	26	.	.	PUNCT
app-717	107	1	all	all	DET
app-717	107	2	women	woman	NOUN
app-717	107	3	,	,	PUNCT
app-717	107	4	but	but	CCONJ
app-717	107	5	especially	especially	ADV
app-717	107	6	older	old	ADJ
app-717	107	7	women	woman	NOUN
app-717	107	8	,	,	PUNCT
app-717	107	9	do	do	AUX
app-717	107	10	not	not	PART
app-717	107	11	have	have	VERB
app-717	107	12	equal	equal	ADJ
app-717	107	13	representation	representation	NOUN
app-717	107	14	in	in	ADP
app-717	107	15	health	health	NOUN
app-717	107	16	research	research	NOUN
app-717	107	17	.	.	PUNCT
app-717	108	1	further	further	ADJ
app-717	108	2	investigation	investigation	NOUN
app-717	108	3	is	be	AUX
app-717	108	4	needed	need	VERB
app-717	108	5	to	to	PART
app-717	108	6	deepen	deepen	VERB
app-717	108	7	our	our	PRON
app-717	108	8	understanding	understanding	NOUN
app-717	108	9	of	of	ADP
app-717	108	10	the	the	DET
app-717	108	11	complex	complex	ADJ
app-717	108	12	relationship	relationship	NOUN
app-717	108	13	between	between	ADP
app-717	108	14	hormonal	hormonal	ADJ
app-717	108	15	transitions	transition	NOUN
app-717	108	16	and	and	CCONJ
app-717	108	17	mood	mood	NOUN
app-717	108	18	disorders	disorder	NOUN
app-717	108	19	in	in	ADP
app-717	108	20	women	woman	NOUN
app-717	108	21	.	.	PUNCT
app-717	109	1	references	reference	NOUN
app-717	109	2	alblooshi	alblooshi	ADV
app-717	109	3	,	,	PUNCT
app-717	109	4	s.	s.	PROPN
app-717	109	5	,	,	PUNCT
app-717	109	6	taylor	taylor	PROPN
app-717	109	7	,	,	PUNCT
app-717	109	8	m.	m.	NOUN
app-717	109	9	,	,	PUNCT
app-717	109	10	&	&	CCONJ
app-717	109	11	gill	gill	PROPN
app-717	109	12	,	,	PUNCT
app-717	109	13	n.	n.	NOUN
app-717	109	14	(	(	PUNCT
app-717	109	15	2023	2023	NUM
app-717	109	16	)	)	PUNCT
app-717	109	17	.	.	PUNCT
app-717	110	1	does	do	AUX
app-717	110	2	menopause	menopause	NOUN
app-717	110	3	elevate	elevate	VERB
app-717	110	4	the	the	DET
app-717	110	5	risk	risk	NOUN
app-717	110	6	for	for	ADP
app-717	110	7	developing	develop	VERB
app-717	110	8	depression	depression	NOUN
app-717	110	9	and	and	CCONJ
app-717	110	10	anxiety	anxiety	NOUN
app-717	110	11	?	?	PUNCT
app-717	111	1	results	result	NOUN
app-717	111	2	from	from	ADP
app-717	111	3	a	a	DET
app-717	111	4	systematic	systematic	ADJ
app-717	111	5	review	review	NOUN
app-717	111	6	.	.	PUNCT
app-717	112	1	australasian	australasian	ADJ
app-717	112	2	psychiatry	psychiatry	NOUN
app-717	112	3	,	,	PUNCT
app-717	112	4	31(2	31(2	NUM
app-717	112	5	)	)	PUNCT
app-717	112	6	,	,	PUNCT
app-717	112	7	165	165	NUM
app-717	112	8	-	-	SYM
app-717	112	9	173	173	NUM
app-717	112	10	.	.	PUNCT
app-717	113	1	https://doi.org/10.1177/10398562231165439	https://doi.org/10.1177/10398562231165439	VERB
app-717	113	2	bagarić	bagarić	PROPN
app-717	113	3	,	,	PUNCT
app-717	113	4	b.	b.	PROPN
app-717	113	5	,	,	PUNCT
app-717	113	6	jokić	jokić	PROPN
app-717	113	7	-	-	PUNCT
app-717	113	8	begić	begić	PROPN
app-717	113	9	,	,	PUNCT
app-717	113	10	n.	n.	NOUN
app-717	113	11	,	,	PUNCT
app-717	113	12	&	&	CCONJ
app-717	113	13	sangster	sangster	PROPN
app-717	113	14	jokić	jokić	PROPN
app-717	113	15	,	,	PUNCT
app-717	113	16	c.	c.	PROPN
app-717	113	17	(	(	PUNCT
app-717	113	18	2022	2022	NUM
app-717	113	19	)	)	PUNCT
app-717	113	20	.	.	PUNCT
app-717	114	1	the	the	DET
app-717	114	2	nocebo	nocebo	NOUN
app-717	114	3	effect	effect	NOUN
app-717	114	4	:	:	PUNCT
app-717	114	5	a	a	DET
app-717	114	6	review	review	NOUN
app-717	114	7	of	of	ADP
app-717	114	8	contemporary	contemporary	ADJ
app-717	114	9	experimental	experimental	ADJ
app-717	114	10	research	research	NOUN
app-717	114	11	.	.	PUNCT
app-717	115	1	international	international	ADJ
app-717	115	2	journal	journal	NOUN
app-717	115	3	of	of	ADP
app-717	115	4	behavioral	behavioral	ADJ
app-717	115	5	medicine	medicine	NOUN
app-717	115	6	,	,	PUNCT
app-717	115	7	29(3	29(3	NUM
app-717	115	8	)	)	PUNCT
app-717	115	9	,	,	PUNCT
app-717	115	10	255	255	NUM
app-717	115	11	-	-	SYM
app-717	115	12	265	265	NUM
app-717	115	13	.	.	PUNCT
app-717	116	1	https://doi.org/10.1007/s12529-021-10016-y	https://doi.org/10.1007/s12529-021-10016-y	PROPN
app-717	116	2	behrman	behrman	NOUN
app-717	116	3	,	,	PUNCT
app-717	116	4	s.	s.	PROPN
app-717	116	5	,	,	PUNCT
app-717	116	6	&	&	CCONJ
app-717	116	7	crockett	crockett	PROPN
app-717	116	8	,	,	PUNCT
app-717	116	9	c.	c.	PROPN
app-717	116	10	(	(	PUNCT
app-717	116	11	2023	2023	NUM
app-717	116	12	)	)	PUNCT
app-717	116	13	.	.	PUNCT
app-717	117	1	severe	severe	ADJ
app-717	117	2	mental	mental	ADJ
app-717	117	3	illness	illness	NOUN
app-717	117	4	and	and	CCONJ
app-717	117	5	the	the	DET
app-717	117	6	perimenopause	perimenopause	NOUN
app-717	117	7	.	.	PUNCT
app-717	118	1	bjpsych	bjpsych	PROPN
app-717	118	2	bulletin	bulletin	NOUN
app-717	118	3	,	,	PUNCT
app-717	118	4	1–7	1–7	X
app-717	118	5	.	.	PUNCT
app-717	118	6	doi:10.1192	doi:10.1192	NOUN
app-717	118	7	/	/	SYM
app-717	118	8	bjp.2023.89	bjp.2023.89	PROPN
app-717	118	9	58	58	NUM
app-717	118	10	cagnacci	cagnacci	NOUN
app-717	118	11	,	,	PUNCT
app-717	118	12	a.	a.	NOUN
app-717	118	13	,	,	PUNCT
app-717	118	14	&	&	CCONJ
app-717	118	15	venier	veni	ADJ
app-717	118	16	,	,	PUNCT
app-717	118	17	m.	m.	NOUN
app-717	118	18	(	(	PUNCT
app-717	118	19	2019	2019	NUM
app-717	118	20	)	)	PUNCT
app-717	118	21	.	.	PUNCT
app-717	119	1	the	the	DET
app-717	119	2	controversial	controversial	ADJ
app-717	119	3	history	history	NOUN
app-717	119	4	of	of	ADP
app-717	119	5	hormone	hormone	NOUN
app-717	119	6	replacement	replacement	NOUN
app-717	119	7	therapy	therapy	NOUN
app-717	119	8	.	.	PUNCT
app-717	120	1	medicina	medicina	PROPN
app-717	120	2	,	,	PUNCT
app-717	120	3	55(9	55(9	NUM
app-717	120	4	)	)	PUNCT
app-717	120	5	,	,	PUNCT
app-717	120	6	602	602	NUM
app-717	120	7	.	.	PUNCT
app-717	121	1	https://doi.org/10.3390/medicina55090602	https://doi.org/10.3390/medicina55090602	PROPN
app-717	121	2	flores	flore	NOUN
app-717	121	3	,	,	PUNCT
app-717	121	4	v.	v.	ADP
app-717	121	5	a.	a.	PROPN
app-717	121	6	,	,	PUNCT
app-717	121	7	pal	pal	NOUN
app-717	121	8	,	,	PUNCT
app-717	121	9	l.	l.	PROPN
app-717	121	10	,	,	PUNCT
app-717	121	11	&	&	CCONJ
app-717	121	12	manson	manson	PROPN
app-717	121	13	,	,	PUNCT
app-717	121	14	j.	j.	PROPN
app-717	121	15	e.	e.	PROPN
app-717	121	16	(	(	PUNCT
app-717	121	17	2021	2021	NUM
app-717	121	18	)	)	PUNCT
app-717	121	19	.	.	PUNCT
app-717	122	1	hormone	hormone	NOUN
app-717	122	2	therapy	therapy	NOUN
app-717	122	3	in	in	ADP
app-717	122	4	menopause	menopause	NOUN
app-717	122	5	:	:	PUNCT
app-717	122	6	concepts	concept	NOUN
app-717	122	7	,	,	PUNCT
app-717	122	8	controversies	controversy	NOUN
app-717	122	9	,	,	PUNCT
app-717	122	10	and	and	CCONJ
app-717	122	11	approach	approach	NOUN
app-717	122	12	to	to	ADP
app-717	122	13	treatment	treatment	NOUN
app-717	122	14	.	.	PUNCT
app-717	123	1	endocrine	endocrine	ADJ
app-717	123	2	reviews	review	NOUN
app-717	123	3	,	,	PUNCT
app-717	123	4	42(6	42(6	NOUN
app-717	123	5	)	)	PUNCT
app-717	123	6	,	,	PUNCT
app-717	123	7	720	720	NUM
app-717	123	8	-	-	SYM
app-717	123	9	752	752	NUM
app-717	123	10	.	.	PUNCT
app-717	124	1	https://doi.org/10.1210/endrev/bnab011	https://doi.org/10.1210/endrev/bnab011	PRON
app-717	124	2	giannini	giannini	PROPN
app-717	124	3	,	,	PUNCT
app-717	124	4	a.	a.	NOUN
app-717	124	5	,	,	PUNCT
app-717	124	6	caretto	caretto	ADJ
app-717	124	7	,	,	PUNCT
app-717	124	8	m.	m.	NOUN
app-717	124	9	,	,	PUNCT
app-717	124	10	genazzani	genazzani	NOUN
app-717	124	11	,	,	PUNCT
app-717	124	12	a.	a.	PROPN
app-717	124	13	r.	r.	PROPN
app-717	124	14	,	,	PUNCT
app-717	124	15	&	&	CCONJ
app-717	124	16	simoncini	simoncini	PROPN
app-717	124	17	,	,	PUNCT
app-717	124	18	t.	t.	NOUN
app-717	124	19	(	(	PUNCT
app-717	124	20	2021	2021	NUM
app-717	124	21	)	)	PUNCT
app-717	124	22	.	.	PUNCT
app-717	125	1	neuroendocrine	neuroendocrine	ADJ
app-717	125	2	changes	change	NOUN
app-717	125	3	during	during	ADP
app-717	125	4	menopausal	menopausal	ADJ
app-717	125	5	transition	transition	NOUN
app-717	125	6	.	.	PUNCT
app-717	126	1	endocrines	endocrine	NOUN
app-717	126	2	,	,	PUNCT
app-717	126	3	2(4	2(4	NUM
app-717	126	4	)	)	PUNCT
app-717	126	5	,	,	PUNCT
app-717	126	6	405	405	NUM
app-717	126	7	-	-	SYM
app-717	126	8	416	416	NUM
app-717	126	9	.	.	PUNCT
app-717	127	1	https://doi.org/10.3390/endocrines2040036	https://doi.org/10.3390/endocrines2040036	PROPN
app-717	127	2	goldštajn	goldštajn	PROPN
app-717	127	3	,	,	PUNCT
app-717	127	4	m.	m.	NOUN
app-717	127	5	š	š	PROPN
app-717	127	6	.	.	PROPN
app-717	127	7	,	,	PUNCT
app-717	127	8	mikuš	mikuš	PROPN
app-717	127	9	,	,	PUNCT
app-717	127	10	m.	m.	NOUN
app-717	127	11	,	,	PUNCT
app-717	127	12	ferrari	ferrari	PROPN
app-717	127	13	,	,	PUNCT
app-717	127	14	f.	f.	PROPN
app-717	127	15	a.	a.	PROPN
app-717	127	16	,	,	PUNCT
app-717	127	17	bosco	bosco	PROPN
app-717	127	18	,	,	PUNCT
app-717	127	19	m.	m.	NOUN
app-717	127	20	,	,	PUNCT
app-717	127	21	uccella	uccella	PROPN
app-717	127	22	,	,	PUNCT
app-717	127	23	s.	s.	PROPN
app-717	127	24	,	,	PUNCT
app-717	127	25	noventa	noventa	PROPN
app-717	127	26	,	,	PUNCT
app-717	127	27	m.	m.	NOUN
app-717	127	28	,	,	PUNCT
app-717	127	29	...	...	PUNCT
app-717	127	30	&	&	CCONJ
app-717	127	31	garzon	garzon	PROPN
app-717	127	32	,	,	PUNCT
app-717	127	33	s.	s.	PROPN
app-717	127	34	(	(	PUNCT
app-717	127	35	2023	2023	NUM
app-717	127	36	)	)	PUNCT
app-717	127	37	.	.	PUNCT
app-717	128	1	effects	effect	NOUN
app-717	128	2	of	of	ADP
app-717	128	3	transdermal	transdermal	ADJ
app-717	128	4	versus	versus	ADP
app-717	128	5	oral	oral	ADJ
app-717	128	6	hormone	hormone	NOUN
app-717	128	7	replacement	replacement	NOUN
app-717	128	8	therapy	therapy	NOUN
app-717	128	9	in	in	ADP
app-717	128	10	postmenopause	postmenopause	NOUN
app-717	128	11	:	:	PUNCT
app-717	128	12	a	a	DET
app-717	128	13	systematic	systematic	ADJ
app-717	128	14	review	review	NOUN
app-717	128	15	.	.	PUNCT
app-717	129	1	archives	archive	NOUN
app-717	129	2	of	of	ADP
app-717	129	3	gynecology	gynecology	NOUN
app-717	129	4	and	and	CCONJ
app-717	129	5	obstetrics	obstetric	NOUN
app-717	129	6	,	,	PUNCT
app-717	129	7	307(6	307(6	NUM
app-717	129	8	)	)	PUNCT
app-717	129	9	,	,	PUNCT
app-717	129	10	1727	1727	NUM
app-717	129	11	-	-	SYM
app-717	129	12	1745	1745	NUM
app-717	129	13	.	.	PUNCT
app-717	130	1	https://doi.org/10.1007/s00404-022-06647-5	https://doi.org/10.1007/s00404-022-06647-5	NUM
app-717	130	2	jin	jin	PROPN
app-717	130	3	,	,	PUNCT
app-717	130	4	j.	j.	PROPN
app-717	130	5	(	(	PUNCT
app-717	130	6	2017	2017	NUM
app-717	130	7	)	)	PUNCT
app-717	130	8	.	.	PUNCT
app-717	131	1	vaginal	vaginal	ADJ
app-717	131	2	and	and	CCONJ
app-717	131	3	urinary	urinary	ADJ
app-717	131	4	symptoms	symptom	NOUN
app-717	131	5	of	of	ADP
app-717	131	6	menopause	menopause	NOUN
app-717	131	7	.	.	PUNCT
app-717	132	1	jama	jama	PROPN
app-717	132	2	,	,	PUNCT
app-717	132	3	317(13	317(13	NUM
app-717	132	4	)	)	PUNCT
app-717	132	5	,	,	PUNCT
app-717	132	6	1388	1388	NUM
app-717	132	7	-	-	SYM
app-717	132	8	1388	1388	NUM
app-717	132	9	.	.	PUNCT
app-717	133	1	kulkarni	kulkarni	PROPN
app-717	133	2	,	,	PUNCT
app-717	133	3	j.	j.	PROPN
app-717	133	4	,	,	PUNCT
app-717	133	5	gurvich	gurvich	NOUN
app-717	133	6	,	,	PUNCT
app-717	133	7	c.	c.	PROPN
app-717	133	8	,	,	PUNCT
app-717	133	9	mu	mu	PROPN
app-717	133	10	,	,	PUNCT
app-717	133	11	e.	e.	PROPN
app-717	133	12	,	,	PUNCT
app-717	133	13	molloy	molloy	PROPN
app-717	133	14	,	,	PUNCT
app-717	133	15	g.	g.	PROPN
app-717	133	16	,	,	PUNCT
app-717	133	17	lovell	lovell	PROPN
app-717	133	18	,	,	PUNCT
app-717	133	19	s.	s.	PROPN
app-717	133	20	,	,	PUNCT
app-717	133	21	mansberg	mansberg	PROPN
app-717	133	22	,	,	PUNCT
app-717	133	23	g.	g.	PROPN
app-717	133	24	,	,	PUNCT
app-717	133	25	...	...	PUNCT
app-717	133	26	&	&	CCONJ
app-717	133	27	szoeke	szoeke	ADJ
app-717	133	28	,	,	PUNCT
app-717	133	29	c.	c.	PROPN
app-717	133	30	(	(	PUNCT
app-717	133	31	2024	2024	NUM
app-717	133	32	)	)	PUNCT
app-717	133	33	.	.	PUNCT
app-717	134	1	menopause	menopause	NOUN
app-717	134	2	depression	depression	NOUN
app-717	134	3	:	:	PUNCT
app-717	134	4	under	under	ADP
app-717	134	5	recognised	recognise	VERB
app-717	134	6	and	and	CCONJ
app-717	134	7	poorly	poorly	ADV
app-717	134	8	treated	treat	VERB
app-717	134	9	.	.	PUNCT
app-717	135	1	australian	australian	PROPN
app-717	135	2	&	&	CCONJ
app-717	135	3	new	new	PROPN
app-717	135	4	zealand	zealand	PROPN
app-717	135	5	journal	journal	PROPN
app-717	135	6	of	of	ADP
app-717	135	7	psychiatry	psychiatry	NOUN
app-717	135	8	,	,	PUNCT
app-717	135	9	58(8	58(8	NUM
app-717	135	10	)	)	PUNCT
app-717	135	11	,	,	PUNCT
app-717	135	12	636	636	NUM
app-717	135	13	-	-	SYM
app-717	135	14	640	640	NUM
app-717	135	15	.	.	PUNCT
app-717	135	16	manson	manson	PROPN
app-717	135	17	,	,	PUNCT
app-717	135	18	j.	j.	PROPN
app-717	135	19	e.	e.	PROPN
app-717	135	20	,	,	PUNCT
app-717	135	21	crandall	crandall	PROPN
app-717	135	22	,	,	PUNCT
app-717	135	23	c.	c.	PROPN
app-717	135	24	j.	j.	PROPN
app-717	135	25	,	,	PUNCT
app-717	135	26	rossouw	rossouw	PROPN
app-717	135	27	,	,	PUNCT
app-717	135	28	j.	j.	PROPN
app-717	135	29	e.	e.	PROPN
app-717	135	30	,	,	PUNCT
app-717	135	31	chlebowski	chlebowski	PROPN
app-717	135	32	,	,	PUNCT
app-717	135	33	r.	r.	PROPN
app-717	135	34	t.	t.	PROPN
app-717	135	35	,	,	PUNCT
app-717	135	36	anderson	anderson	PROPN
app-717	135	37	,	,	PUNCT
app-717	135	38	g.	g.	PROPN
app-717	135	39	l.	l.	PROPN
app-717	135	40	,	,	PUNCT
app-717	135	41	stefanick	stefanick	PROPN
app-717	135	42	,	,	PUNCT
app-717	135	43	m.	m.	NOUN
app-717	135	44	l.	l.	PROPN
app-717	135	45	,	,	PUNCT
app-717	135	46	...	...	PUNCT
app-717	135	47	&	&	CCONJ
app-717	135	48	prentice	prentice	PROPN
app-717	135	49	,	,	PUNCT
app-717	135	50	r.	r.	PROPN
app-717	135	51	l.	l.	PROPN
app-717	135	52	(	(	PUNCT
app-717	135	53	2024	2024	NUM
app-717	135	54	)	)	PUNCT
app-717	135	55	.	.	PUNCT
app-717	136	1	the	the	DET
app-717	136	2	women	woman	NOUN
app-717	136	3	’s	’s	PART
app-717	136	4	health	health	NOUN
app-717	136	5	initiative	initiative	NOUN
app-717	136	6	randomized	randomize	VERB
app-717	136	7	trials	trial	NOUN
app-717	136	8	and	and	CCONJ
app-717	136	9	clinical	clinical	ADJ
app-717	136	10	practice	practice	NOUN
app-717	136	11	:	:	PUNCT
app-717	136	12	a	a	DET
app-717	136	13	review	review	NOUN
app-717	136	14	.	.	PUNCT
app-717	137	1	jama	jama	PROPN
app-717	137	2	,	,	PUNCT
app-717	137	3	331(20):1748	331(20):1748	PROPN
app-717	137	4	-	-	SYM
app-717	137	5	1760	1760	NUM
app-717	137	6	.	.	PUNCT
app-717	138	1	https://doi:10.1001	https://doi:10.1001	PROPN
app-717	138	2	/	/	SYM
app-717	138	3	jama.2024.6542	jama.2024.6542	PROPN
app-717	138	4	marsden	marsden	PROPN
app-717	138	5	,	,	PUNCT
app-717	138	6	j.	j.	PROPN
app-717	138	7	(	(	PUNCT
app-717	138	8	2022	2022	NUM
app-717	138	9	)	)	PUNCT
app-717	138	10	.	.	PUNCT
app-717	139	1	the	the	DET
app-717	139	2	british	british	PROPN
app-717	139	3	menopause	menopause	PROPN
app-717	139	4	society	society	PROPN
app-717	139	5	consensus	consensus	NOUN
app-717	139	6	statement	statement	NOUN
app-717	139	7	on	on	ADP
app-717	139	8	the	the	DET
app-717	139	9	management	management	NOUN
app-717	139	10	of	of	ADP
app-717	139	11	estrogen	estrogen	NOUN
app-717	139	12	deficiency	deficiency	NOUN
app-717	139	13	symptoms	symptom	NOUN
app-717	139	14	,	,	PUNCT
app-717	139	15	arthralgia	arthralgia	NOUN
app-717	139	16	and	and	CCONJ
app-717	139	17	menopause	menopause	NOUN
app-717	139	18	diagnosis	diagnosis	NOUN
app-717	139	19	in	in	ADP
app-717	139	20	women	woman	NOUN
app-717	139	21	with	with	ADP
app-717	139	22	treated	treat	VERB
app-717	139	23	for	for	ADP
app-717	139	24	early	early	ADJ
app-717	139	25	breast	breast	NOUN
app-717	139	26	cancer	cancer	NOUN
app-717	139	27	.	.	PUNCT
app-717	140	1	post	post	VERB
app-717	140	2	reproductive	reproductive	ADJ
app-717	140	3	health	health	NOUN
app-717	140	4	,	,	PUNCT
app-717	140	5	28(4	28(4	NUM
app-717	140	6	)	)	PUNCT
app-717	140	7	,	,	PUNCT
app-717	140	8	199	199	NUM
app-717	140	9	-	-	SYM
app-717	140	10	210	210	NUM
app-717	140	11	.	.	PUNCT
app-717	141	1	raz	raz	PROPN
app-717	141	2	,	,	PUNCT
app-717	141	3	l.	l.	PROPN
app-717	141	4	,	,	PUNCT
app-717	141	5	hunter	hunter	NOUN
app-717	141	6	,	,	PUNCT
app-717	141	7	l.	l.	PROPN
app-717	141	8	v.	v.	PROPN
app-717	141	9	,	,	PUNCT
app-717	141	10	dowling	dowle	VERB
app-717	141	11	,	,	PUNCT
app-717	141	12	n.	n.	NOUN
app-717	141	13	m.	m.	NOUN
app-717	141	14	,	,	PUNCT
app-717	141	15	wharton	wharton	PROPN
app-717	141	16	,	,	PUNCT
app-717	141	17	w.	w.	PROPN
app-717	141	18	,	,	PUNCT
app-717	141	19	gleason	gleason	PROPN
app-717	141	20	,	,	PUNCT
app-717	141	21	c.	c.	PROPN
app-717	141	22	e.	e.	PROPN
app-717	141	23	,	,	PUNCT
app-717	141	24	jayachandran	jayachandran	NOUN
app-717	141	25	,	,	PUNCT
app-717	141	26	m.	m.	NOUN
app-717	141	27	,	,	PUNCT
app-717	141	28	anderson	anderson	PROPN
app-717	141	29	,	,	PUNCT
app-717	141	30	l.	l.	PROPN
app-717	141	31	,	,	PUNCT
app-717	141	32	asthana	asthana	PROPN
app-717	141	33	,	,	PUNCT
app-717	141	34	s.	s.	PROPN
app-717	141	35	&	&	CCONJ
app-717	141	36	miller	miller	PROPN
app-717	141	37	,	,	PUNCT
app-717	141	38	v.	v.	ADP
app-717	141	39	m.	m.	NOUN
app-717	141	40	(	(	PUNCT
app-717	141	41	2016	2016	NUM
app-717	141	42	)	)	PUNCT
app-717	141	43	.	.	PUNCT
app-717	142	1	differential	differential	ADJ
app-717	142	2	effects	effect	NOUN
app-717	142	3	of	of	ADP
app-717	142	4	hormone	hormone	NOUN
app-717	142	5	therapy	therapy	NOUN
app-717	142	6	on	on	ADP
app-717	142	7	serotonin	serotonin	NOUN
app-717	142	8	,	,	PUNCT
app-717	142	9	vascular	vascular	ADJ
app-717	142	10	function	function	NOUN
app-717	142	11	and	and	CCONJ
app-717	142	12	mood	mood	NOUN
app-717	142	13	in	in	ADP
app-717	142	14	the	the	DET
app-717	142	15	keeps	keep	NOUN
app-717	142	16	.	.	PUNCT
app-717	143	1	climacteric	climacteric	NOUN
app-717	143	2	,	,	PUNCT
app-717	143	3	19(1	19(1	NUM
app-717	143	4	)	)	PUNCT
app-717	143	5	,	,	PUNCT
app-717	143	6	49	49	NUM
app-717	143	7	-	-	SYM
app-717	143	8	59	59	NUM
app-717	143	9	.	.	PUNCT
app-717	144	1	https://doi.org/10.3109/13697137.2015.1116504	https://doi.org/10.3109/13697137.2015.1116504	PROPN
app-717	144	2	slavich	slavich	PROPN
app-717	144	3	,	,	PUNCT
app-717	144	4	g.	g.	PROPN
app-717	144	5	m.	m.	PROPN
app-717	144	6	,	,	PUNCT
app-717	144	7	&	&	CCONJ
app-717	144	8	sacher	sacher	PROPN
app-717	144	9	,	,	PUNCT
app-717	144	10	j.	j.	PROPN
app-717	144	11	(	(	PUNCT
app-717	144	12	2019	2019	NUM
app-717	144	13	)	)	PUNCT
app-717	144	14	.	.	PUNCT
app-717	145	1	stress	stress	NOUN
app-717	145	2	,	,	PUNCT
app-717	145	3	sex	sex	NOUN
app-717	145	4	hormones	hormone	NOUN
app-717	145	5	,	,	PUNCT
app-717	145	6	inflammation	inflammation	NOUN
app-717	145	7	,	,	PUNCT
app-717	145	8	and	and	CCONJ
app-717	145	9	major	major	ADJ
app-717	145	10	depressive	depressive	ADJ
app-717	145	11	disorder	disorder	NOUN
app-717	145	12	:	:	PUNCT
app-717	145	13	extending	extend	VERB
app-717	145	14	social	social	ADJ
app-717	145	15	signal	signal	NOUN
app-717	145	16	transduction	transduction	NOUN
app-717	145	17	theory	theory	NOUN
app-717	145	18	of	of	ADP
app-717	145	19	depression	depression	NOUN
app-717	145	20	to	to	PART
app-717	145	21	account	account	VERB
app-717	145	22	for	for	ADP
app-717	145	23	sex	sex	NOUN
app-717	145	24	differences	difference	NOUN
app-717	145	25	in	in	ADP
app-717	145	26	mood	mood	NOUN
app-717	145	27	disorders	disorder	NOUN
app-717	145	28	.	.	PUNCT
app-717	146	1	psychopharmacology	psychopharmacology	NOUN
app-717	146	2	,	,	PUNCT
app-717	146	3	236(10	236(10	NUM
app-717	146	4	)	)	PUNCT
app-717	146	5	,	,	PUNCT
app-717	146	6	3063	3063	NUM
app-717	146	7	-	-	SYM
app-717	146	8	3079	3079	NUM
app-717	146	9	.	.	PUNCT
app-717	147	1	stefaniak	stefaniak	PROPN
app-717	147	2	,	,	PUNCT
app-717	147	3	m.	m.	NOUN
app-717	147	4	,	,	PUNCT
app-717	147	5	dmoch	dmoch	NOUN
app-717	147	6	-	-	PUNCT
app-717	147	7	gajzlerska	gajzlerska	NOUN
app-717	147	8	,	,	PUNCT
app-717	147	9	e.	e.	PROPN
app-717	147	10	,	,	PUNCT
app-717	147	11	jankowska	jankowska	PROPN
app-717	147	12	,	,	PUNCT
app-717	147	13	k.	k.	PROPN
app-717	147	14	,	,	PUNCT
app-717	147	15	rogowski	rogowski	PROPN
app-717	147	16	,	,	PUNCT
app-717	147	17	a.	a.	NOUN
app-717	147	18	,	,	PUNCT
app-717	147	19	kajdy	kajdy	PROPN
app-717	147	20	,	,	PUNCT
app-717	147	21	a.	a.	PROPN
app-717	147	22	,	,	PUNCT
app-717	147	23	&	&	CCONJ
app-717	147	24	maksym	maksym	PROPN
app-717	147	25	,	,	PUNCT
app-717	147	26	r.	r.	PROPN
app-717	147	27	b.	b.	PROPN
app-717	147	28	(	(	PUNCT
app-717	147	29	2023	2023	NUM
app-717	147	30	)	)	PUNCT
app-717	147	31	.	.	PUNCT
app-717	148	1	progesterone	progesterone	NOUN
app-717	148	2	and	and	CCONJ
app-717	148	3	its	its	PRON
app-717	148	4	metabolites	metabolite	NOUN
app-717	148	5	play	play	VERB
app-717	148	6	a	a	DET
app-717	148	7	beneficial	beneficial	ADJ
app-717	148	8	role	role	NOUN
app-717	148	9	in	in	ADP
app-717	148	10	affect	affect	VERB
app-717	148	11	regulation	regulation	NOUN
app-717	148	12	in	in	ADP
app-717	148	13	the	the	DET
app-717	148	14	female	female	ADJ
app-717	148	15	brain	brain	NOUN
app-717	148	16	.	.	PUNCT
app-717	149	1	pharmaceuticals	pharmaceutical	NOUN
app-717	149	2	,	,	PUNCT
app-717	149	3	16(4	16(4	NUM
app-717	149	4	)	)	PUNCT
app-717	149	5	,	,	PUNCT
app-717	149	6	520	520	NUM
app-717	149	7	.	.	PUNCT
app-717	150	1	https://doi.org/10.3390/ph16040520	https://doi.org/10.3390/ph16040520	NOUN
app-717	150	2	59	59	NUM
app-717	150	3	wieczorek	wieczorek	NOUN
app-717	150	4	,	,	PUNCT
app-717	150	5	k.	k.	PROPN
app-717	150	6	,	,	PUNCT
app-717	150	7	targonskaya	targonskaya	PROPN
app-717	150	8	,	,	PUNCT
app-717	150	9	a.	a.	PROPN
app-717	150	10	,	,	PUNCT
app-717	150	11	&	&	CCONJ
app-717	150	12	maslowski	maslowski	ADJ
app-717	150	13	,	,	PUNCT
app-717	150	14	k.	k.	PROPN
app-717	150	15	(	(	PUNCT
app-717	150	16	2023	2023	NUM
app-717	150	17	)	)	PUNCT
app-717	150	18	.	.	PUNCT
app-717	151	1	reproductive	reproductive	ADJ
app-717	151	2	hormones	hormone	NOUN
app-717	151	3	and	and	CCONJ
app-717	151	4	female	female	ADJ
app-717	151	5	mental	mental	ADJ
app-717	151	6	wellbeing	wellbeing	NOUN
app-717	151	7	.	.	PUNCT
app-717	152	1	women	woman	NOUN
app-717	152	2	,	,	PUNCT
app-717	152	3	3(3	3(3	NUM
app-717	152	4	)	)	PUNCT
app-717	152	5	,	,	PUNCT
app-717	152	6	432	432	NUM
app-717	152	7	-	-	SYM
app-717	152	8	444	444	NUM
app-717	152	9	.	.	PUNCT
app-717	152	10	wilson	wilson	PROPN
app-717	152	11	,	,	PUNCT
app-717	152	12	r.	r.	PROPN
app-717	152	13	a.	a.	PROPN
app-717	152	14	(	(	PUNCT
app-717	152	15	1968	1968	NUM
app-717	152	16	)	)	PUNCT
app-717	152	17	.	.	PUNCT
app-717	153	1	feminine	feminine	ADJ
app-717	153	2	forever	forever	ADV
app-717	153	3	.	.	PUNCT
app-717	154	1	pocket	pocket	NOUN
app-717	154	2	books	book	NOUN
app-717	154	3	.	.	PUNCT
app-717	155	1	ye	ye	PRON
app-717	155	2	,	,	PUNCT
app-717	155	3	z.	z.	PROPN
app-717	155	4	,	,	PUNCT
app-717	155	5	kappelmann	kappelmann	PROPN
app-717	155	6	,	,	PUNCT
app-717	155	7	n.	n.	PROPN
app-717	155	8	,	,	PUNCT
app-717	155	9	moser	moser	PROPN
app-717	155	10	,	,	PUNCT
app-717	155	11	s.	s.	PROPN
app-717	155	12	,	,	PUNCT
app-717	155	13	smith	smith	PROPN
app-717	155	14	,	,	PUNCT
app-717	155	15	g.	g.	PROPN
app-717	155	16	d.	d.	PROPN
app-717	155	17	,	,	PUNCT
app-717	155	18	burgess	burgess	PROPN
app-717	155	19	,	,	PUNCT
app-717	155	20	s.	s.	PROPN
app-717	155	21	,	,	PUNCT
app-717	155	22	jones	jones	PROPN
app-717	155	23	,	,	PUNCT
app-717	155	24	p.	p.	PROPN
app-717	155	25	b.	b.	PROPN
app-717	155	26	,	,	PUNCT
app-717	155	27	&	&	CCONJ
app-717	155	28	khandaker	khandaker	PROPN
app-717	155	29	,	,	PUNCT
app-717	155	30	g.	g.	PROPN
app-717	155	31	m.	m.	PROPN
app-717	155	32	(	(	PUNCT
app-717	155	33	2021	2021	NUM
app-717	155	34	)	)	PUNCT
app-717	155	35	.	.	PUNCT
app-717	156	1	role	role	NOUN
app-717	156	2	of	of	ADP
app-717	156	3	inflammation	inflammation	NOUN
app-717	156	4	in	in	ADP
app-717	156	5	depression	depression	NOUN
app-717	156	6	and	and	CCONJ
app-717	156	7	anxiety	anxiety	NOUN
app-717	156	8	:	:	PUNCT
app-717	156	9	tests	test	VERB
app-717	156	10	for	for	ADP
app-717	156	11	disorder	disorder	NOUN
app-717	156	12	specificity	specificity	NOUN
app-717	156	13	,	,	PUNCT
app-717	156	14	linearity	linearity	NOUN
app-717	156	15	and	and	CCONJ
app-717	156	16	potential	potential	ADJ
app-717	156	17	causality	causality	NOUN
app-717	156	18	of	of	ADP
app-717	156	19	association	association	NOUN
app-717	156	20	in	in	ADP
app-717	156	21	the	the	DET
app-717	156	22	uk	uk	PROPN
app-717	156	23	biobank	biobank	PROPN
app-717	156	24	.	.	PUNCT
app-717	157	1	eclinicalmedicine	eclinicalmedicine	PROPN
app-717	157	2	,	,	PUNCT
app-717	157	3	38	38	NUM
app-717	157	4	.	.	PUNCT
app-717	158	1	https://doi.org/10.1016/j.eclinm.2021.100992	https://doi.org/10.1016/j.eclinm.2021.100992	PROPN