Archives of Academic Emergency Medicine. 2022; 10(1): e62 OR I G I N A L RE S E A RC H Comparing the Outcomes of Surgical and Non-Surgical Approaches in Management of Older Patients with Distal Radius Fracture; a Retrospective Cohort Study Mehdi Teimouri 1, Milad Ghaderi2∗, Saeed Hatami1 1. Department of Orthopedic Surgery, Kashani University Hospital, School of Medicine, Isfahan University of Medical Science, Isfahan, Iran. 2. School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. Received: May 2022; Accepted: June 2022; Published online: 2 August 2022 Abstract: Introduction: Distal radius fractures (DRFs) are the most common orthopedic injuries in emergency depart- ment. This study aimed to compare the outcomes of conservative and surgical managements of DRFs in the aged population. Methods: In this retrospective cohort study, ninety patients with unilateral DRFs were treated using either surgical or conservative (casting) approach and the management outcomes as well as complica- tions were compared between the two groups at 3 and 6-month follow-ups. Results: A total of 90 patients over 70 years old were included (45 treated with cast immobilization, and 45 using the surgical method). The mean age (p = 0.56) and gender (p = 0.85) was similar in the two groups. Except for quality of life in both follow-up times, patients treated with surgical methods showed better outcomes in other aspects, including 3-month (p = 0.042) and 6-month (p = 0.022) mean Disability of the Arm Shoulder Hand (DASH) score, 3-month (p = 0.013) and 6-month (p = 0.006) mean range of motion (ROM), and 3-month (p = 0.003) and 6-month (p = 0.033) pain in- tensity based on Visual Analogue Scale (VAS). A total of 70 (77.77%) adverse events were registered (33 (36.6%) in the casting group and 37 (41.1%) in the surgical group; p = 0.05). The rate of mal-union (p = 0.021) and superficial radial nerve injury (p = 0.026) were significantly lower in the surgical group. Conclusion: The findings suggest that surgical approach for management of DRFs in elder cases has better clinical and functional outcomes than cast immobilization. Keywords: Conservative treatment; radius fractures; casts, surgical; aged; disabled persons Cite this article as: Teimouri M, Ghaderi M, Hatami S. Comparing the Outcomes of Surgical and Non-Surgical Approaches in Man- agement of Older Patients with Distal Radius Fracture; a Retrospective Cohort Study. Arch Acad Emerg Med. 2022; 10(1): e62. https://doi.org/10.22037/aaem.v10i1.1606. 1. Introduction Distal radius fractures (DRFs) are among the most common orthopedic injuries, with over 640,000 cases reported during 2001 in the US alone. This type of fracture accounts for up to 18% of all fractures in the elderly age group (1). Epidemiolog- ical studies point out that the highest incidences are found in children and the elderly people with the elderly group (over 65 years old) making up more than 50% of all DRF cases in the population (2). The age-adjusted incidence in large stud- ies ranges from 73 to 202 per 100,000 in men and from 309 to 767 per 100,000 in women among adults over 50 years old ∗Corresponding Author: Milad Ghaderi; School of Medicine, Isfahan Uni- versity of Medical Sciences, Isfahan, Iran. Tel: +98-9136886840, Email: mi- ladghaderi6@gmail.com, ORCID: https://orcid.org/0000-0002-6487-5469. (2). An, peripheral low-energy fracture is a strong indication of osteoporosis (3). Patients with distal radius fracture have been found to carry twice the risk of a later hip fracture (4). In older adults, especially females, the fracture results from low- energy or moderate trauma, such as falling from a standing height. And some studies showed that there is an increased tendency to fall among patients over 65 years old (5). This indicates that greater fragility of the bone, resulting from os- teoporosis and osteopenia, in combination with an increased tendency to fall are major risk factors for distal radius frac- tures, along with other risk factors such as prior forearm or vertebral fractures, loss of body height, cigarette smoking, and medical treatment for certain diseases (e.g. rheumatoid arthritis) (5, 6). There are several surgical options for this kind of injury, and each option has its advantages and complications. The This open-access article distributed under the terms of the Creative Commons Attribution NonCommercial 3.0 License (CC BY-NC 3.0). Downloaded from: http://journals.sbmu.ac.ir/aaem M. Teimouri et al. 2 American Academy of Orthopedic Surgeons is currently un- able to recommend any specific treatment, whether conser- vative or surgical. In the latter case, they also do not suggest which surgical approach is best (7). Choice of treatment de- pends on many factors, such as the patient’s age, lifestyle, associated medical conditions, compliance, functional de- mands, limb dominance, type of fracture, severity, and align- ment of the fracture, condition of the soft tissue, and con- comitant fractures (8, 9). In the last century, most distal ra- dius fractures in adults were treated non-operatively (conser- vatively) by reducing the fracture when displaced and stabi- lization in a plaster cast or other external brace. The results of such treatment, particularly in older people with bones weakened by osteoporosis, are not consistently satisfactory (10). Treatment by closed reduction and cast immobilization can be carried out on a large scale, at low expense, and with- out admission; however, this often leads to poor radiological results and displacement, the rate of which can be as high as 40% (11). This has resulted in attempts to develop surgery strategies aimed at more accurate reduction and more reli- able stabilization. Several surgical options for distal radius fractures have been described, such as percutaneous pinning and casting (closed reduction) (12) and external fixation (12, 13); Open Reduction Internal Fixation (ORIF) using the volar locking plate technique represents the most chosen option, ORIF with Herbert screw fixation and crif with k-wire (13, 14). Percutaneous pinning involves percutaneous (through the skin) insertion of pins, which may be threaded or wired (12). In external fixation, which is also a closed, minimally invasive method, metal pins or screws are driven into bone, generally via small skin incisions, after drilling them on ei- ther side of the fracture. These pins are then fixed externally with a plaster cast or an external fixator frame (12, 13). For both methods, fracture reduction is generally closed (15). In- ternal fixation, which is usually preceded by open reduction, involves open surgery, where the fractured bone is exposed to direct view. Given the invasive and technically demand- ing nature of open surgery, with the increased risks of infec- tion and soft-tissue damage, internal fixation is usually re- served for more severe injuries. It is, however, an increasingly used method of surgery (16). Amongst these surgical meth- ods, volar locking plate systems (VLPS) offer predictable out- comes, especially in osteoporotic patients, and their use is increasingly popular (17-20). There is also a paucity of evi- dence on the optimal treatment of distal radius fractures in the Iranian population. This study aimed to compare the clinical and functional out- comes as well as quality of life of older patients with DRF be- tween two treatment approaches of cast immobilization and surgery. 2. Methods 2.1. Study design and setting A retrospective cohort study on 90 age- and gender-matched patients treated for DRF at two different referral Hospitals (Alzahra and Kashani) in Isfahan, Iran, was conducted be- tween 2020 and 2021. Patients were either treated with surgical or conservative (casting) approaches due to dif- ferent variables (i.e., associated medical conditions, type of fracture, severity and alignment of the fracture, surgical method, surgeon technique, and experience) and the man- agement outcomes as well as complications were compared between groups at 3 and 6-month follow-ups. Ethical code IR.MUI.MED.REC.1399.1005 was obtained from Isfahan Uni- versity of Medical Sciences. Consents were obtained from all patients. Researched adhered to confidentiality of pa- tients’ data and ethical recommendations in the declaration of Helsinki. 2.2. Participants Patients aged 70 years or older, with unilateral distal radius fracture, no history of upper limb surgery following trauma, no morbidity such as limb paralysis and preoperative defor- mity, and at least 6 months of follow-up after non-operative or operative treatment were included. Cases who had bilat- eral distal radius fractures, other associated injuries, or open fractures, and patients who did not give consent to partici- pate in our study were excluded. All fractures were classified as B1 and B2 types based on orthopedic trauma association. 2.3. Procedure and interventions All fractures underwent an initial closed reduction. All the Patients in both groups were radiologically examined three months and six months after the procedure to verify the sta- bility of the reduction and the outcomes. The conservatively treated patients were immobilized with a long cast, and after four weeks, the arm portion of the cast was removed while the forearm part was kept for another 2-4 weeks. Then the cast was removed, and patients were advised for functional recovery of the wrist articulation. Patients in the surgical group were treated within one week from the traumatic event using different methods like open reduction internal fixa- tion (ORIF), percutaneous pinning (PCP), and external fixa- tion methods. After the surgery, a splint was applied to the forearm. The immobilization for patients treated with PCP and external fixation was kept for 4-6 weeks and for those in ORIF group, it was kept for two weeks, followed by rehabili- tation. The rehabilitation consisted of physical therapy pro- grams and functional training in self-care and home man- agement. This open-access article distributed under the terms of the Creative Commons Attribution NonCommercial 3.0 License (CC BY-NC 3.0). Downloaded from: http://journals.sbmu.ac.ir/aaem 3 Archives of Academic Emergency Medicine. 2022; 10(1): e62 2.4. Outcome assessment All patients’ clinical and functional outcomes were evaluated using three questionnaires at the 3- and 6-month follow-ups. Also, the range of motion (ROM) in injured and contralat- eral wrists were evaluated and compared between groups at the 3- and 6-month follow-ups. The Short Form 36 (SF36) was used to analyze the quality of life, the Disability of the Arm Shoulder Hand (DASH) was used to assess wrist func- tion, and a Visual Analogue Scale (VAS) was used to evaluate the pain intensity. 2.4.1 Short Form 36 (SF36) The SF-36 is a general quality of life instrument that mea- sures eight health-related concepts: physical functioning (PF-10 items), role limitations due to physical problems (RP- 4 items), bodily pain (BP-2 items), general health percep- tions (GH-5 items)), vitality (VT-4 items), social function- ing (SF-2 items), role limitations due to emotional problems (RE-3 items), and perceived mental health (MH-5 items). In addition, a single item that provides an indication of per- ceived change in general health status over a one-year period (health transition) is also included in the SF-36 .(21) 2.4.2. Disability of the Arm, Shoulder, and Hand Score (DASH) To assess the patient’s functional status during the preced- ing week, the validated Persian version of the Disability of the Arm, Shoulder, and Hand Score (DASH), was used. The questionnaire is designed to evaluate the degree of difficulty in performing several physical activities because of an arm, shoulder or hand problem (21 items), the severity of each of the symptoms of pain, activity-related pain, tingling, weak- ness and stiffness (5 items), as well as the effects of the con- dition on social activities, work, and self-image (4 items). The DASH also contains two optional four-item modules con- cerning the ability to work (work module) and to practice sports or play musical instruments (sports/performing arts module) .(22) 2.4.3. Visual Analogue Scale ( VAS) The pain Visual Analogue Scale (VAS) is a single-item scale, a unidimensional measure of pain intensity. For pain inten- sity, the scale is most commonly anchored by “no pain” (score of 0) and “pain as bad as it could be” or “unbearable pain” (score of 10). The VAS is widely used due to its simplicity and adaptability to a broad range of populations and settings and is broadly accepted as a generic pain measure. 2.4.4. Range of motion For range of motion, we measured the amount of wrist flex- ion and extension as well as radial and ulnar deviation in both fractured and other wrists at 3-month and 6-month follow-ups. The maximum motion of a normal wrist required for daily activities is 60 degrees of extension, 54 degrees of flexion, 40 degrees of ulnar deviation, and 16 degrees of ra- dial deviation, a total of 170 degrees. 2.5. Statistical analysis Continuous and categorical variables were reported as mean ± standard deviation (SD) and frequency (percentage), re- spectively. Continuous variables were compared between groups using independent samples t-test and categorical variables were compared using chi-squared or Fisher exact tests. All statistical analyses were performed using SPSS ver- sion 26 (IBM SPSS Statistics for Windows, version XX (IBM Corp., Armonk, N.Y., USA) 3. Results 3.1. Baseline characteristics A total of 90 patients over 70 years old were included in this study. 45 patients were treated with cast immobilization, and 45 cases were treated using surgical methods. The patients’ mean age at the time of trauma was 77.84 ± 5.90 (range: 70- 93) years for the surgical group and 77.47 ± 5.4 (range: 70- 90) years for the conservative group (p = 0.56). The two groups were predominated by women (60% vs. 68%; p = 0.85) and had a similar situation regarding mean DASH (84.10 vs. 83.7; p = 0.83), mean pain intensity (7.30 vs. 7.50; p = 0.89), and mean range of motion (68.60 vs. 70.20; p = 0.78) at the time of admission. 3.2. Outcomes All patients were evaluated in the 3- and 6-month follow-ups. Table 1 compares the studied outcomes as well as compli- cations between the groups 3 and 6 months after interven- tion. Except for quality of life in both follow-up times, pa- tients treated with surgical methods showed better outcomes in other aspects, including 3-month (p = 0.042) and 6-month (p = 0.022) mean DASH, 3-month (p = 0.013) and 6-month (p = 0.006) mean ROM, and 3-month (p = 0.003) and 6-month (p = 0.033) pain intensity based on VAS. 3.3. Complications A total of 70 (77.77%) adverse events were registered (33 (36.6%) in the casting group and 37 (41.1%) in the surgical group; p = 0.05). In both casting and surgical groups, the most prevalent observed complication was mal-union (25 (27.7%) vs. 10 (11.1%); p = 0.021, respectively), followed by Need for reoperation (9 (10%) vs. 8 (8.8%); p = 0.321, respec- tively). The rate of mal-union (p = 0.021) and superficial ra- dial nerve injury (p = 0.026) were significantly lower in surgi- cal group. This open-access article distributed under the terms of the Creative Commons Attribution NonCommercial 3.0 License (CC BY-NC 3.0). Downloaded from: http://journals.sbmu.ac.ir/aaem M. Teimouri et al. 4 Table 1: Comparing the studied outcomes and complications between the 2 groups 3 and 6 months after intervention Outcome Surgery Group n = 45 Casting Group n = 45 P-value Disability of the Arm Shoulder Hand (DASH) 3 months 63.02 ± 9.57 68.29 ± 14.52 0.042 6 months 53.80 ± 9.01 60.04 ± 15.58 0.022 SF-36 3 months 64.20 ± 12.74 62.84 ± 10.31 0.135 6 months 76.87 ± 12.52 70.64 ± 10.92 0.295 Pain intensity based on Visual Analogue Scale ( VAS) 3 months 3.02 ± 0.98 3.60 ± 1.07 0.009 6 months 1.98 ± 0.86 2.38 ± 0.88 0.033 Range of motion (ROM) 3 months 129.56 ± 13.00 121.89 ± 15.49 0.013 6 months 146.00 ± 13.67 138.11± 13.11 0.006 Complications Mal-union 10 (11.1) 25 (27.7) 0.021 Surgical site infection 5 (5.5) 0 (0.0) 0.05 Superficial radial nerve injury 6 (6.6) 0 (0.0) 0.026 Un-union 4 (4.4) 3 (3.3) 0.214 Need for reoperation 8 (8.8) 9 (10) 0.321 Total 33 (36.6) 37 (41.1) 0.05 Data are reported as mean ± standard deviation or frequency (%). At the time of admission, the difference between groups regarding the DASH, ROM, and pain intensity was not significant. 4. Discussion Our data showed significant difference between outcomes of DRF management in patients who underwent conserva- tive and casting treatments. Clinical outcomes in surgical group were better than casting group. We found a signifi- cant difference in complications between two groups: mal- union and superficial radial nerve injury were significantly lower in surgical group. We considered that a distal radius fracture would affect the whole upper extremity, resulting in a temporary or long-term physical performance impairment (13). This concept applies especially to the elderly popula- tion, who are more sensitive to a health-related reduction in quality of life and mobility skills (14). Patients who suffer a DRF usually experience long-term functional impairments that restrict daily activities (2). Distal radius fractures are very common injuries among the elderly, and most DRFs that occur in elderly persons are a source of morbidity and loss of quality of life (23). Even though DRFs are among the most common injuries treated by orthopedic trauma and hand surgeons, the treatment op- tions are vast and the best choice for each case remains de- batable variable and remain debatable (6). Prevention of this fracture is possible by treating osteoporosis with diet and drugs, including vitamin D, calcium, and bisphosphonate medications. Several studies have investigated the functional and radiological outcomes in osteoporotic DRF-affected pa- tients; some authors have highlighted that osteoporosis has a negative effect on clinical outcomes in DRFs after surgery and suggested that the cause may be the complications re- lated to the low bone mass density of the distal radius, in- cluding loss of fixation and late displacement (24). Some investigators performing similar studies have stated that there is no significant difference in patient’s overall out- comes between two groups. Testa et al. evaluated 91 patients aged 65 years and older with DRFs, treated in two groups (cast immobilization versus ORIF), 1, 3, 6, and 12 months af- ter intervention using similar methods to our study, and they found no significant clinical difference between the casting and the surgical group(25) . Arora et al. in a similar study, came to the same conclusion and found no significant dif- ference between 2 treatment methods of DRF (26). Ju et al. in a meta-analysis of eight studies similar to ours in 2015 compared surgical treatment (440 patient) and cast immo- bilization (449 patients) and found no significant differences in DASH score, VAS pain score, grip strength, wrist exten- sion, pronation, supination, or ulnar deviation between the groups. However, they found that the non-surgical group had significantly greater wrist flexion, radial deviation, ulnar vari- ance, and less radial inclination than the surgical group. And they concluded that surgical and non-surgical methods pro- duce similar results in treatment of DRFs in the elderly, and minor objective functional differences did not impact sub- jective function outcome and quality of life . (27) However, the results of our study were similar to the trends observed in some other studies (9, 12, 28), where surgically treated patients tended to achieve better upper extremity function, experience lower pain intensity and greater range This open-access article distributed under the terms of the Creative Commons Attribution NonCommercial 3.0 License (CC BY-NC 3.0). Downloaded from: http://journals.sbmu.ac.ir/aaem 5 Archives of Academic Emergency Medicine. 2022; 10(1): e62 of motion after treatment, and usually need fewer physical therapy sessions in comparison to casting group to achieve a rather similar function. Hung et al. in a study in 2016 con- cluded that surgical methods resulted in better functional outcomes for DRFs in Chinese older adults aged 61 to 80 years(29) . After 3-month and 6-month follow-ups, our data showed a significant clinical difference between the casting and the surgical groups, with a better outcome using dif- ferent surgical methods. This study found a significant im- provement in outcomes in the DASH, pain score, and range of motion (flexion, extension, and radial deviation) using sur- gical methods. However, there seemed to be no significant difference between the SF-36 scores of the two groups. This data may suggest that despite the absence of a significant difference in the quality of life between the two groups, the functional outcomes in the mid-term are better in surgically treated patients. Thus, the surgical methods are a more ad- missible option in treating DRFs. We found a difference in the incidence of complications: 23.3% in the surgical group and 33.3% in the conservative group. Mal-union (38.8% in total) had the highest incidence among registered adverse events in both groups, and approx- imately 1 out of 3 patients, regardless of the fixation method, were diagnosed with mal-union in follow-ups. Regardless of the fixation method, surgical management may result in complications. Since the incidence of complications in the surgical group has been lower, it can be concluded that func- tional outcomes have been better in this group. On the sub- ject of difference between the results of our study and sim- ilar investigations done by other authors, we found that in those studies (25-27) they registered more incidence of ad- verse events in the surgically treated patients in follow-ups (35–45 %) and this may result in worse functional outcome, resulting in the insignificant difference between 2 groups; and as we discussed before, there are many variables that af- fect both the choice of treatment and outcomes of the cho- sen treatment, such as the patient’s age, lifestyle, associated medical conditions, compliance, functional demands, limb dominance, type of fracture, severity, alignment of the frac- ture, condition of the soft tissue, and concomitant fractures. Bruce et al. in their study in 2016 point out the absence of a consensus strategy for the treatment of distal radius frac- tures and the implications of variance in treatment on cost and quality of care, and indicate the need for established, evidence-based guidelines or further clinical trials to assist in the management of this common fracture(30) . The result of our investigation suggests that surgical methods are a more admissible option for the treatment of DRFs; however, fur- ther prospective randomized controlled studies with larger numbers will be required to evaluate the potential long-term benefits of surgical treatment. This study prospectively in- vestigated the outcome of DRFs in Iranian elderly patients, and the results followed the trend observed in the general el- derly population in other parts of the world (9, 12, 28, 29). 5. Limitations Selection bias due to lack of randomization and heteroge- neous fracture configuration within the group might have limited our results’ power. Also, we did not divide fractures into subgroups and we did not separately evaluate the de- vices used in surgery. 6. Conclusion Our findings suggest that using surgical methods in treat- ment of DRFs in the elderly seems to be a more admissible option than cast immobilization. The affected limb’s func- tional outcomes and range of motion were better after surgi- cal treatment compared to cast immobilization treatment. 7. Declarations 7.1. Acknowledgments None. 7.2. Authors’ contributions M.Gh designed the study, wrote the proposal and initial draft. S.H analyzed the data, gathered data, entered them into SPSS, and edited the manuscript. M.T introduced the idea, supervised the study, and revised the final draft. 7.3. Funding and supports None. 7.4. Conflict of interest None. References 1. Nellans KW, Kowalski E, Chung KC. 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Bruce KK, Merenstein DJ, Narvaez MV, Neufeld SK, This open-access article distributed under the terms of the Creative Commons Attribution NonCommercial 3.0 License (CC BY-NC 3.0). Downloaded from: http://journals.sbmu.ac.ir/aaem 7 Archives of Academic Emergency Medicine. 2022; 10(1): e62 Paulus MJ, Tan TP, et al. Lack of Agreement on Dis- tal Radius Fracture Treatment. J Am Board Fam Med. 2016;29(2):218-25. This open-access article distributed under the terms of the Creative Commons Attribution NonCommercial 3.0 License (CC BY-NC 3.0). Downloaded from: http://journals.sbmu.ac.ir/aaem Introduction Methods Results Discussion Limitations Conclusion Declarations References