Emergency (****); * (*): *-* This open-access article distributed under the terms of the Creative Commons Attribution Noncommercial 3.0 License (CC BY-NC 3.0). Copyright © 2016 Shahid Beheshti University of Medical Sciences. All rights reserved. Downloaded from: www.jemerg.com 106 Emergency (2016); 4 (2): 106-107 CASR REPORT Peganum Harmala (Aspand) Intoxication; a Case Report Rezvan Sadr Mohammadi1, Reza Bidaki 2*, Fazlollah Mirdrikvand3, Seyyed Nader Mostafavi Yazdi 4, Pouria Yazdian Anari5 1. Department of Psychology, Kar Higher Education Institute, Rafsanjan, Iran. 2. Department of Psychiatry, Research Center of Addiction and Behavioral Sciences, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. 3. Department of Psychology, Lorestan University, Khorram Abad, Iran. 4. Department of Toxicology and Legal Psychiatry, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. 5. Research Committee, Shahid Sadoughi University of Medical Science, Yazd, Iran. *Corresponding Author: Reza Bidaki; Department of Psychiatry, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Tel: +983532632004; Fax: +983532623555; Email: Reza_Bidaki@yahoo.com Received: June 2015; Accepted: August 2015 Abstract There are several reports in the literature indicating a great variety of pharmacological effects for peganum har- mala or aspand such as sedative anti-bacterial, anti-fungal, antiviral and antiprotozoal. Some people believe that can be used for treatment of some organic or psychiatric disorders. We introduce a woman with history of long time constipation that was disappointed in novel medical treatment and decided to use comminuted Aspand to relieve her problem .Two hours after use, the intoxication symptoms manifested as blurred vision, phonophobia, floating feeling, and tinnitus ringing. Here we report the treatment process and outcome of this case. Keywords: Peganum; harmine; poisoning; emergency department Cite this article as Sadr Mohammadi R, Bidaki R, Mirdrikvand F, Mostafavi Yazdi SN, Yazdian Anari P. Peganum harmala (aspand) intoxication; a case report. Emergency. 2016; 4(2):106-107. Introduction: eganum harmala commonly known as Syrian Rue or “Aspand” is widely used in middle East and North Africa (1, 2). Various parts of harmala are used in traditional medicine. The pharmacologically active com- pounds of this herb are several alkaloids, which are found especially in the seeds and roots (3). It was used as seda- tive in restless and agitated patients. Its seeds are known to possess hypothermic, hallucinogenic and anti-oxidative properties (3, 4). There are several reports in the litera- ture indicating a great variety of pharmacological effects for this plant such as sedative anti-bacterial, anti-fungal, antiviral and antiprotozoal (5, 6). It is also used illegally as an abortifacient agent (4). Aspand intoxication is among very rare causes of intoxication, with a mortality rate of about 6%. Nevertheless in some countries, it makes up 4.6% of all plant intoxications (7). Ingestion is the main route of intoxication, but inhalation and fumigation are also mentioned (8). There are few studies on related symptoms following consumption and intoxication with Aspand (9-11). Here we report a case of harmala intoxica- tion presented to emergency department with psychiatric complaint. Case presentation: The patient was a 54-year-old woman presented to the emergency department with severe vomiting and ab- rupt onset of various neuropsychological symptoms. She was a housewife with low socioeconomic level. Her relatives mentioned that she had suffered from chronic constipation that did not respond to the common medi- cine. Therefore, following the recommendation of a friend, she had made a mixture of 50 grams of grinded aspand, water and sugar. Two hours after taking the cocktail, the symptoms were manifested as blurred vi- sion, phonophobia, floating feeling, tinnitus ringing, and repetitive moving backward or forward. Family history for psychiatric disorders was negative. She had con- trolled hypertension from some years ago treated with atenolol tablet 100 mg/per day. On admission, she was lethargic and also disoriented to person, time and place. The patient had mild tachycardia (Heart rate: 105/minute) and increased blood pressure (Blood pressure: 160/90 mmHg) with oral temperature of 37.8 ◦C. Physical examination of the head, neck, chest, abdo- men, and extremities did not show any positive finding. The neurological examination revealed somnolence, P Copyright © 2016 Shahid Beheshti University of Medical Sciences. All rights reserved. Downloaded from: www.jemerg.com 107 Emergency (2016); 4 (2): 106-107 depersonalization, derealization, poor concentration, and ataxia. Blood glucose level, blood gas analysis, bio- chemistry profile, and brain imaging were reported as normal. 12 leads electrocardiography revealed normal sinus tachycardia. Since the patient history was reliable, Harmala intoxication was the definite diagnosis. She was treated with intravenous fluid of dextrose/saline, metoclopramide and antacid. After 12 hours of con- servative management, signs and symptoms of toxicity were relieved and she left the hospital in a stable condi- tion. Outpatient follow-up revealed full recovery with no complication. Discussion: Aspand intoxication usually is transient and self-limited and improves with supportive therapy. But consuming a high dose of it accidentally, intentionally, or for sui- cidal attempt may cause mortality. Aspand intoxication can cause various symptoms like misperception, im- pairment in sensorium and cognition, mild hyperther- mia, or on the contrary, autonomic dysfunction like bradycardia and hypotension (7, 12). The sympto- matology is dominated as neurological, gastrointestinal, and cardiovascular, respectively . In a study by Mahmoudian et al., tremor and seizure without in- creased spinal reflex, respiratory paralysis, hypother- mia, and central nervous system suppression were reported as main manifestations of the mentioned in- toxication (2). Yet, our patient had tremor and increase in deep tendon reflexes. It is suggested that this herb can imitate a monoamine oxidase inhibitor effect (6). The manifestations are dose dependent and higher dos- age may increase probability of poisoning. Drug sub- stance and metal poisoning can have the same presen- tation (4, 13). Since there is no specific anti-dote for this type of poisoning, the standard treatment is control of vital signs and supportive therapy. There are dissocia- tive, psychotic and anxiety states that need special symptomatic treatment. Conclusion: Aspand may be used for various purposes, but ingestion can be so dangerous and life threatening. It imitates psychiatric and neurological presentation and can cause morbidity and mortality especially in higher doses. Acknowledgment We acknowledge all the staff of internal medicine ser- vice and emergency unit of Shahid Beheshti hospital of Taft for handling this patient. Conflict of interest: None Funding support: None Authors’ contributions: All authors passed four criteria for authorship contribu- tion based on recommendations of the International Committee of Medical Journal Editors. Rezvan Sadr Mo- hammadi and Reza Bidaki wrote the manuscript, Fazlollah Mirdrikvand revised a part of it, Nader Mo- stafavi and Reza Bidaki designed it, Reza Bidaki and Pouria Yazdian revised and submitted it. References: 1. Bahmani M, Rafieian-Kopaei M, Parsaei P, Mohsenzadegan A. The anti-leech effect of Peganum harmala L. extract and some anti-parasite drugs on Limnatis nilotica. Afr J Microbiol Res. 2012;6(10):2586-90. 2. Mahmoudian M, Jalipour H, Dardashti PS. Toxicity of Peganum harmala: review and a case report. Iranian Journal of Pharmacology & Therapeutics. 2002;1(1):1-4. 3. Moloudizargari M, Mikaili P, Aghajanshakeri S, Asghari MH, Shayegh J. Pharmacological and therapeutic effects of Peganum harmala and its main alkaloids. Pharmacogn Rev. 2013;7(14):199. 4. Berdai MA, Labib S, Harandou M. Peganum harmala L. Intoxication in a Pregnant Woman. Case reports in emergency medicine. 2014;2014. 5. Aqel M, Hadidi M. Direct relaxant effect of Peganum harmala seed extract on smooth muscles of rabbit and guinea pig. Pharm Biol. 1991;29(3):176-82. 6. Shi C-C, Chen S-Y, Wang G-J, Liao J-F, Chen C-F. Vasorelaxant effect of harman. Eur J Pharmacol. 2000;390(3):319-25. 7. Aarons DH, Victor Rossi G, Orzechowski RF. Cardiovascular actions of three harmala alkaloids: harmine, harmaline, and harmalol. J Pharm Sci. 1977;66(9):1244-8. 8. Rhalem N, Khattabi A, Soulaymani A, Ouammi L, Soulaymani-Bencheikh R. Etude rétrospective des intoxications par les plantes au Maroc: Expérience du Centre Anti Poison et de Pharmacovigilance du Maroc (1980-2008). Toxicologie Maroc. 2010;5:5-8. 9. Casey R. 298 alleged anti-fertility plants of India. 1960. 10. Saha J, Savini E, Kasinathan S. Ecbolic properties of Indian medicinal plants. 1961. 11. Boulos L. Medicinal Plants of North Africa. Medicinal plants of North Africa. 1983. 12. Abdel-Fattah A, Matsumoto K, Murakami Y, El-Hady K, Mohamed M, Watanabe H. Inhibitory effects of Harmaline on the tryptophan induced 5-hvdroxyt syndrome and body tempeRature changes in pargyline-pretreated Rats. Jpn J Pharmacol. 1996;27:39-47. 13. Achour S, Rhalem N, Khattabi A, et al. [Peganum harmala L. poisoning in Morocco: about 200 cases]. Therapie. 2011;67(1):53-8.