Emergency (****); * (*): *-* This open-access article distributed under the terms of the Creative Commons Attribution Noncommercial 3.0 License (CC BY-NC 3.0). Copyright © 2016 Shahid Beheshti University of Medical Sciences. All rights reserved. Downloaded from: www.jemerg.com 108 Emergency (2016); 4 (2): 108-110 CASR REPORT Eosinophilic Gastroenteritis as a Rare Cause of Recurrent Epigastric Pain Mohammad Taghi Safari, Shabnam Shahrokh, Mohammad Bagher Miri, Mohammad Javad Ehsani Ardakani* Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. *Corresponding Author: Mohammad Javad Ehsani Ardakani; Research Institute for Gastroenterology and Liver Diseases, Velenjak Street, Shahid Chamran Highway, Tehran, Iran. Tel: +98 21 22 43 99 82, Email: MJehsani@yahoo.com Received: July 2015; Accepted: August 2015 Abstract Eosinophilic gastroenteritis (EGE) is a rare inflammatory disorder of gastrointestinal tract characterized by eo- sinophilic infiltration of the bowel wall. It can mimic many gastrointestinal disorders due to its wide spectrum of presentations. Diagnose is mostly based on excluding other disorders and a high suspicion. Here we report a case of 26 year old man with a history of sever epigastric pain followed by nausea, vomiting since a few days before admission with final diagnosis of EGE. Keywords: Eosinophilic enteropathy; abdominal pain; endoscopy, Gastrointestinal; emergency department Cite this article as: Safari MT, Shahrokh S, Miri MB, Ehsani Ardakani MJ. Eosinophilic gastroenteritis as a rare cause of recur- rent epigastric pain. Emergency. 2016; 4(2):108-110. Introduction: osinophilic gastroenteritis (EGE) is a rare inflamma- tory disorder of gastrointestinal tract characterized by eosinophilic infiltration of the bowel wall. It can mimic many gastrointestinal disorders due to its wide spectrum of presentations (1, 2). Diagnose is mostly based on excluding other disorders and a high suspicion (3). De- spite of its low prevalence, EGE should be considered as diagnosis in case of recurrent abdominal pains. Lesion biopsies are inevitable for confirming diagnosis and corti- costeroids are alternative treatment for remission (4). Here we report a case of 26-year- old man with a history of sever epigastric pain followed by nausea, vomiting, and oral intake intolerance with final diagnosis of EGE. Case report: A 26-year- old man was seen in emergency department because of severe abdominal pain since one week be- fore admission. His pain was localized to epigastric ar- ea, had burning type and aggravated with feeding with- out any radiation site and was associated with nausea, vomiting and food intolerance. He had no fever, chills, night sweeting, evidence of gastrointestinal bleeding, change in bowel habit, or icterus. On examination, his vital signs were stable and cardiopulmonary examina- tion was normal. He had severe epigastric tenderness without rebound and guarding or distention and bowel sound was present. His past habitual and medical histo- ry has been unremarkable except for allergic rhinitis since five years ago. Complete blood count, serum elec- trolytes, renal and liver function tests, amylase, lipase, and stool exam for parasites and occult blood were all in normal range. Esophagogastroscopy revealed very severe patchy congestion and erosion along with super- ficial ulcers in proximal of body, as well as congestion and erythema in mucosa of entire stomach. Bulb and D2 was severe congestive. Multiple biopsies were taken from stomach and duodenum (Figure1, 2). Histology revealed portion of small intestinal mucosa with intact villous and corpus architecture. There are dens infiltra- tion of eosinophilic inflammatory cells and evidence of their degranulation in lamina properia and submucosa. After ruling out of parasite infection and malignancy and involvement of other organs with negative studies including multiple stool examinations, serology for cer- tain parasites, evaluation of biopsies for malignant cells and other infiltrations, chest and abdominopelvic com- puted tomography (CT) Scan, and echocardiography diagnosis of EGE was established. Treatment with 25 mg prednisolone was began and after 2 days significant resolution of his symptoms was seen. In follow up, after one month, he was completely well, without complain of abdominal pain and nausea or vomiting. Discussion: Eosinophilic gastroenteritis (EGE), is a rare inflamma- tory disorder characterized by eosinophilic infiltration of GI tract wall, especially stomach and duodenum (1). There are limited data on epidemiology of EGE. The prevalence in US is 22-28 per 100000 cases. E This open-access article distributed under the terms of the Creative Commons Attribution NonCommercial 3.0 License (CC BY-NC 3.0). Copyright © 2016 Shahid Beheshti University of Medical Sciences. All rights reserved. Downloaded from: www.jemerg.com 109 Emergency (2016); 4 (2): 108-110 It is mostly seen in white and to some extent Asians and affects adults and children of both sexes with a slight male preponderance (2, 5). Patients present clinically at any age with a peak between third to fifths decades (1, 5). Depending on the location, depth and extent of bowel wall involvement, EGE has a broad spectrum of clinical manifestations from abdominal pain, nausea and vomit- ing to gastrointestinal obstruction and ascites, which can mimic most of gastrointestinal and abdominal pa- thologies. High serum level of IgE is common in these patients. Eczema, atopic diseases, such as asthma, may be accompanied. It also runs a chronic relapsing course (1, 2, 4). The diagnosis is difficult and is mostly based on excluding other diagnoses and a high clinical suspi- cion. The presence of abnormal gastrointestinal symp- toms, along with 20 or more eosinophil per high-power field in one or more areas of the gastrointestinal tract, absence of an identified cause of eosinophilia (para- sites, drug use, and malignancy), exclusion of eosino- philic involvement in organs other than the gastrointes- tinal tract and a history of atopy or food allergies are often necessary for diagnosis (3, 4). The macroscopic appearance of tissue is nonspecific and lesion biopsies are inevitable for confirming diagnosis (6). Gastrointes- tinal obstruction is the most common complication. Treatment should be individualized, considering pa- tient’s age and severity of the symptoms. There are sev- eral reports on the role of elemental or elimination diet on improvement in disease activity (1-3, 5). In patients in whom, diet restriction is not feasible or has failed, low dose steroid therapy is the main therapeutic alter- native. Antihistamines (ketotifen), mast cell stabilizer (oral chromoglycate), and leukotriene antagonists (montelukast) are also used in its treatment (7, 8). Flare-ups can also be controlled with oral corticoster- oids (9). In case of gastrointestinal obstruction, surgery may be inevitable. Conclusion: Eosinophilic gastroenteritis is a rare cause of epigastric pain but, should be considered as differential diagnosis in cases of recurrent abdominal pain. Conflict of interest: None Funding support: None Authors’ contributions: All authors passed four criteria for authorship contribu- tion based on recommendations of the International Committee of Medical Journal Editors. References: 1. Ingle SB, Hinge CR. Eosinophilic gastroenteritis: an unusual type of gastroenteritis. World journal of gastroenterology: WJG. 2013;19(31):5061. 2. Lucendo AJ, Arias A. Eosinophilic gastroenteritis: an update. 2012. 3. Prussin C. Eosinophilic gastroenteritis and related eosinophilic disorders. Gastroenterology Clinics of North America. 2014;43(2):317-27. 4. Spera M, Nicaud M, Gupta M, Raines D, editors. A Case of Subserosal Eosinophilic Gastroenteritis Presenting with Figure 1: Endoscopy and microscopic views of lesion. This open-access article distributed under the terms of the Creative Commons Attribution Noncommercial 3.0 License (CC BY-NC 3.0). Copyright © 2016 Shahid Beheshti University of Medical Sciences. All rights reserved. Downloaded from: www.jemerg.com Safari et al 110 Abdominal Pain and Distension. JOURNAL OF INVESTIGATIVE MEDICINE; 2014: LIPPINCOTT WILLIAMS & WILKINS 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA. 5. Temiz T, Yaylacı S, Demir MV, Kahyaoglu Z, Tamer A, Uslan MI. Eosinophilic gastroenteritis: a rare case report. North American journal of medical sciences. 2012;4(8):367. 6. Kinoshita Y, Furuta K, Ishimaura N, et al. Clinical characteristics of Japanese patients with eosinophilic esophagitis and eosinophilic gastroenteritis. Journal of gastroenterology. 2013;48(3):333-9. 7. Reed C, Woosley JT, Dellon ES. Clinical characteristics, treatment outcomes, and resource utilization in children and adults with eosinophilic gastroenteritis. Digestive and Liver Disease. 2014. 8. Mori A, Enweluzo C, Grier D, Badireddy M. Eosinophilic gastroenteritis: review of a rare and treatable disease of the gastrointestinal tract. Case reports in gastroenterology. 2013;7(2):293. 9. 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