Stesura Seveso 135Archivio Italiano di Urologia e Andrologia 2014; 86, 2 NOTE ON SURGICAL TECHNIQUE Pseudo-capsule “coffin effect”: How to prevent penile retraction after implant of three-piece inflatable prosthesis Enrico Caraceni 1, Lilia Utizi 2, Giovanni Angelozzi 3 Department of Urology, Civitanova Marche Hospital, Italy. Objective: Following three-component implantation of a penile prosthesis, some patients are dissatisfied with their penile length. This may be due to the procedure by itself or pre-existing risk fac- tors or psychological reasons. We supposed that formation of a restricted pseudo-capsule due to a late prosthesis acti- vation can inhibit later system expansion. We aimed to identify the presence or absence of penile retraction after implant and to prevent it by immediate prosthesis activa- tion after implantation. Material and methods. Forty-six patients operated with three-piece inflatable penile prosthesis (AMS 700 CX o LGX) were enrolled. In 27 patients prosthesis was first activated four weeks after surgery (NEA group) and in 19 patients prosthesis was activated immediately after surgery (DEA group). Length and girth of the penis was evaluated before (in DEA group) and after the surgical procedure. Results. The average post implant dorsal length of the erect penis in group NEA was found 3.28 cm shorter than in group with early activation (DEA). In DEA group there was no lenght difference between pre-operative stretching (14.57 cm) and post operative erection (14.98 cm). When early activation was not performed, the clinical result was a smaller penis in erect phase. Conclusion. Reduced lenght of the penis after implantation can be caused by the presence of a pseudo-capsule that limits the elongation of the prosthesis and of the penis (“coffin effect”). Timing of first activation seems to be the key in order to prevent the risk of penile retraction after implantation. Early activation is identified as the best measure to maintain the length of the pre implant erect penis after the prosthetic hydraulic implant. KEY WORDS: Penile prosthesis length; Penile retraction; Early activation; LGX penile prosthesis; AMS 700 CX penile prosthesis; Coffin effect, Three piece penile prosthesis; Size of the penis; Shortening of the penis. Submitted 23 December 2013; Accepted 29 March 2014 Summary No conflict of interest declared pointment can be severe and in some cases can lead to loss of use of the prosthesis even when it is working well. First Montorsi et al. in 2000 (4) reported that about 30% of patients complained a decrease in penile size after three-piece prosthesis implantation. The authors explained the finding as follows: this dissat- isfaction is linked with the loss of engorgement of the glans or to the recall of the natural preexisting erection, or to the pre-operatory penis size loss. Deveci et al. in 2007 (5) wrote there were no statistically significant differences in penile length after the surgery compared to preoperative measurements in a group of 56 patients affected of erectyle dysfunction (ED) of vari- ous nature, excluding Peyronie’s disease. Patients had the penile length measured at the beginning of the operation prior to device implantation (stretched flaccid length), and at 1 and 6 months postoperatively (dorsal length with activated prosthesis). Length was measured from the pubic bone to meatus along the dorsum of the shaft. They did not find significative difference in preoperative stretched penis and postoperative penile length with the activated device. In their experience about two of three patients (72%) surprisingly complained decreased in penile length. They explained that this feeling might be related to a comparison with their penile length before the onset of ED, or to pre-implant penile length reduc- tion related to radical prostatectomy or other penile fibrotics changes. They concluded that patient and part- ner education from the beginning may limit unrealistic expectations after implantation. Patient should be advised that penile implants may not restore the full length once achieved by natural erections. Treatment sat- isfaction appears not to be fully dependent on subjective penile length and then the failure in sizing (told by 72% of their patients) is not real but subjective. Montague (6) in 2007 published a review of literature on the penis size matter after penile implants. He recognized that it is likely that inflatable penile prosthesis implanta- tion does not provide a prosthetic erection quite as long as a natural erection. He believed that the loss of penile sizing could be attributed to the fact that prosthetic erec- tion does not include glans tumescence or to penile retraction due to preoperatory factors, like radical prostatectomy. However, he concluded it is necessary to speak to the patient telling him: “your preoperative DOI: 10.4081/aiua.2014.2.135 INTRODUCTION Following implants of a penile prosthesis some couples are dissatisfied with penile length and girth (1-3). This may be one reason for implant dissatisfaction: disap- Archivio Italiano di Urologia e Andrologia 2014; 86, 2 E. Caraceni, L. Utizi, G. Angelozzi 136 stretched penile length will approximately be like your erect length after prosthetic surgery”. Shaeer et al. (7) in a recent paper published in Sexual Medicine in 2010 about his surgical technique to improve penile size after inflatable prosthesis implanta- tion, classified the possible causes of the loss of penis size after implantation. They wrote “decrease in size may some- times be a mental impression due to unrealistic expectations, poor counseling, or dysmorphophobia”. Alternatively, diminished phallic size may be real and due to the inherent nature of the procedure or to a preexisting pathology. The latter includes cases of fibrosis following radiotherapy, neglected priapism, and Peyronie’s disease, all of which exhibit shortening and/or narrowing, or cases with overhanging suprapubic fat leading to concealment. In such cases, diminished size is not a result of the proce- dure itself, but rather due to an ignored preexisting com- plaint of undersized phallus, shadowed by erectile dys- function (ED), a complaint that the physician failed to rec- ognize and address. On the other hand, actual diminution in size may be iatrogenic, caused by the procedure itself. Shaeer and al recognized that there is a real loss of penis size after implantation techniques and proposes expansion to correct the defect and improve patient and partner’s sat- isfaction. However, he lacked the demonstration of his statements about the real loss in size after installation. His work is only about the surgical technique to supersize the penis following penile prosthesis implantation. Levine and Rybak in 2011 (8) concluded that there is not recognised reliable technique to gain length once the device is placed and proposed the use of external traction therapy prior to inflatable penile prosthesis placement to solve the problem. Moskovic (9) obtained the same results in a case treated using the same method of Levine. Finally, other authors proposed preoperatory Vacuum Device treatment (10, 11). We believe the loss of length and girth of the penis after prosthetic hydraulic implant is a multi-factorial phenomenon: preexisting factors like obesity, penile fibrosis (post priapism or post induratio penis plastica), pelvic surgery (radical prostatectomy, cystectomy or abdominal amputation of the rectus) can reduce “per se” penile size (12, 13), but in addition to these factors pseudo-capsule formation could play an important role in reducing the penis after implant. In fact in case of late activation of the prosthetic device a pseudo-capsule can form around the deactivated empty implant that is smaller in size with respect to the fully activated implant. When the prosthesis is activated after three or four weeks, as recommended by the manufac- turers (14, 15), it cannot expand further due to the resistance of pseudo-capsule, which is so far fully formed. In other words the pseudo-capsule prevents the full prosthesis expansion, thus determining a reduction of the true size of the penis working like an inextensible wall. We have called this phenomenon “coffin effect” of pseudo capsule. The “coffin effect” should be added to other predisposing factors of penile size reduction and it is always present. If the prosthesis is not left inflated immediately after the surgery and for subsequent two or three weeks the result will be a smaller penis with simi- lar dimensions to the non activated prosthesis. Aim of this study was to identify the presence or absence of penile retraction after implant with three-component prosthesis and to evaluate the possibility to prevent it by immediate activation of the prosthesis after the surgical procedure without use of other device or other surgical strategies before or after the operation (16-19). CONCLUSIONS According to our observations we confirmed the occur- rence of a “true” penile shortening after prosthetic implant (11.70 cm in the NEA group). This can be caused by the formation of a pseudo capsule, that develops around the non activated implant that acts as a “wall” that subsequently prevents the prostesis expansion and the potential elongation of the penis after implantation. The pseudo capsule limits the dimension of the penis and the prosthesis can only move like a “slid- ing door” inside it forward during activation and back- ward when it is deactivated. The result is a larger penis in flaccid state but smaller in erect phase expecially when early activation was not performed. The implant can work like an expander, if well used, but the size of the penis is limited by the pseudocapsule. This “coffin effect” explains the retraction and the lower elasticity of the penis that can occur after implantation as a consequence of the formation of the pseudo capsule. The decreased elastic capacity of the penis after penile prosthesis implantation involves a lower difference between penile length in flaccid and erect state and larger length and girth of the flaccid penis. This is confirmed by the observation that early activation as an effective measure to prevent penile shortening after implanta- tion. LGX implant can improve the length (15.35 in DEA group versus 11.90 in NEA group) and girth (12.43 in DEA group ver- sus 11.90 in NEA group) of the penis only if early activated. In conclusions early activa- tion is a measure to prevent the loss of length of the erect penis after implantation. 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J Sex Med. 2012;9:2389-95. 137Archivio Italiano di Urologia e Andrologia 2014; 86, 2 Early activation to prevent penile retraction after prosthesis implant Correspondence Enrico Caraceni, MD Director of Department of Urology - Civitanova Marche Hospital Civitanova Marche, Italy ecarace@libero.it Lilia Utizi, Clinical Psychologist (Corresponding Author) Sexual Behavior Consultant - Department of Urology - Civitanova Marche Hospital Civitanova Marche, Italy l.utizi@libero.it. Giovanni Angelozzi, MD Department of Urology - Civitanova Marche Hospital Civitanova Marche, Italy giovauro@yahoo.it