id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
aiua-5198	Brardi, Simone; Cevenini, Gabriele; Verdacchi, Tiziano; Romano, Giuseppe; Ponchietti, Roberto	Use of cinacalcet in nephrolithiasis associated with normocalcemic or hypercalcemic primary hyperparathyroidism: results of a prospective randomized pilot study	2015	6	.pdf	application/pdf	6053	216	35	the normalization of parathyroid hormone induced by cinacalcet, used in combination with a diet with normalized calcium intake, allows to control the primary cause of the renal stone complication and thus achieve, as long as you continue therapy, a concrete clinical advantage in terms of reduc- tion in the number and size of stones, similarly to what can be definitely achieved, with greater certainty, by sur- gical parathyroidectomy that is definitely associated with a significant risk reduction of calcium stones,frequent remission or reduction of relapses (27, 28). We excluded patients with known causes of secondary elevation of parathyroid hormone such as 25-hydroxyvitamin D deficiency (defined as serum 25-hydroxyvitamin D less than 20 ng/ml) (16), decreased creatinine clearance (defined as the finding of a GFR less than 50 ml/min) (14), use of drugs such as hydrochloroth- iazide and lithium salts, gastrointestinal disorders associat- ed to malabsorption of calcium and idiopathic hypercalci- uria (defined as the presence of urinary calcium > 300 mg/24 h in men and 250 mg/24 h in women or urinary calcium levels in 24 hour urine greater than 4 mg/kg body weight for both sexes in the absence of known causes of hypercalciuria such as sarcoidosis, rapidly progressive osteoporosis, excessive intake of vitamin D or calcium, immobilization, hyperthyroidism, renal tubular acidosis and the presence of any neoplasm) (17).	cache/aiua-5198.pdf	txt/aiua-5198.txt