id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
aiua-5738	Pirozzi Farina, Furio; Pischedda, Antonella	Comments concerning the real risk of sexual adverse events secondary to the use of 5-ARIs	2016	5	.pdf	application/pdf	4139	197	56	In this same paper, the Authors reported that finasteride- and dutasteride- induced sexual dysfunction resolved completely when treatment was discontinued and that, in any case, in approximately 4% of patients, treatment was discontin- ued due to sexual adverse events. Finasteride is above all an inhibitor of 5a-R2 and is approximately 50 times weaker in inhibiting 5a- R1 than 5a-R2; for this reason, finasteride is able to reduce serum 5a-DHT by about 70% (9). INDICATIONS FOR TREATMENT WITH 5a-R INHIBITORS The 5a-RIs finasteride and dutasteride were developed for the treatment of patients with urinary disorders sec- 313Archivio Italiano di Urologia e Andrologia 2015; 87, 4 Comments concerning the real risk of sexual adverse events secondary to the use of 5-ARIs by a recent literature review by Abdulmaged MT, et al. (2011), in which the finding of sexual adverse events attributed to the use of 5a-RIs is compared with data relating to the use of placebo (2).	cache/aiua-5738.pdf	txt/aiua-5738.txt