id	sid	tid	token	lemma	pos
aiua-12464	1	1	stesura	stesura	PROPN
aiua-12464	1	2	seveso	seveso	PROPN
aiua-12464	1	3	archivio	archivio	PROPN
aiua-12464	1	4	italiano	italiano	X
aiua-12464	1	5	di	di	X
aiua-12464	1	6	urologia	urologia	PROPN
aiua-12464	1	7	e	e	PROPN
aiua-12464	1	8	andrologia	andrologia	NOUN
aiua-12464	1	9	2024	2024	NUM
aiua-12464	1	10	;	;	PUNCT
aiua-12464	1	11	96(3):12464	96(3):12464	NUM
aiua-12464	1	12	1	1	NUM
aiua-12464	1	13	original	original	ADJ
aiua-12464	1	14	paper	paper	NOUN
aiua-12464	1	15	sterile	sterile	ADJ
aiua-12464	1	16	but	but	CCONJ
aiua-12464	1	17	healthy	healthy	ADJ
aiua-12464	1	18	men	man	NOUN
aiua-12464	1	19	and	and	CCONJ
aiua-12464	1	20	up	up	ADP
aiua-12464	1	21	to	to	PART
aiua-12464	1	22	25	25	NUM
aiua-12464	1	23	%	%	NOUN
aiua-12464	1	24	of	of	ADP
aiua-12464	1	25	obstructive	obstructive	ADJ
aiua-12464	1	26	azoospermia	azoospermia	NOUN
aiua-12464	1	27	cases	case	NOUN
aiua-12464	1	28	(	(	PUNCT
aiua-12464	1	29	2	2	NUM
aiua-12464	1	30	)	)	PUNCT
aiua-12464	1	31	.	.	PUNCT
aiua-12464	2	1	to	to	ADP
aiua-12464	2	2	date	date	NOUN
aiua-12464	2	3	,	,	PUNCT
aiua-12464	2	4	two	two	NUM
aiua-12464	2	5	perspectives	perspective	NOUN
aiua-12464	2	6	have	have	AUX
aiua-12464	2	7	been	be	AUX
aiua-12464	2	8	presented	present	VERB
aiua-12464	2	9	regarding	regard	VERB
aiua-12464	2	10	the	the	DET
aiua-12464	2	11	etiology	etiology	NOUN
aiua-12464	2	12	of	of	ADP
aiua-12464	2	13	the	the	DET
aiua-12464	2	14	cbavd	cbavd	NOUN
aiua-12464	2	15	:	:	PUNCT
aiua-12464	2	16	vas	vas	X
aiua-12464	2	17	deferens	deferens	PROPN
aiua-12464	2	18	atresia	atresia	PROPN
aiua-12464	2	19	and	and	CCONJ
aiua-12464	2	20	vas	vas	X
aiua-12464	2	21	deferens	deferens	NOUN
aiua-12464	2	22	agenesis	agenesis	NOUN
aiua-12464	2	23	.	.	PUNCT
aiua-12464	3	1	even	even	ADV
aiua-12464	3	2	though	though	SCONJ
aiua-12464	3	3	the	the	DET
aiua-12464	3	4	comprehensive	comprehensive	ADJ
aiua-12464	3	5	pathological	pathological	ADJ
aiua-12464	3	6	mechanism	mechanism	NOUN
aiua-12464	3	7	is	be	AUX
aiua-12464	3	8	required	require	VERB
aiua-12464	3	9	to	to	PART
aiua-12464	3	10	be	be	AUX
aiua-12464	3	11	further	far	ADV
aiua-12464	3	12	studied	study	VERB
aiua-12464	3	13	and	and	CCONJ
aiua-12464	3	14	validated	validate	VERB
aiua-12464	3	15	,	,	PUNCT
aiua-12464	3	16	these	these	DET
aiua-12464	3	17	pathological	pathological	ADJ
aiua-12464	3	18	mechanisms	mechanism	NOUN
aiua-12464	3	19	are	be	AUX
aiua-12464	3	20	widely	widely	ADV
aiua-12464	3	21	known	know	VERB
aiua-12464	3	22	to	to	PART
aiua-12464	3	23	be	be	AUX
aiua-12464	3	24	triggered	trigger	VERB
aiua-12464	3	25	by	by	ADP
aiua-12464	3	26	gene	gene	NOUN
aiua-12464	3	27	alterations	alteration	NOUN
aiua-12464	3	28	(	(	PUNCT
aiua-12464	3	29	3	3	NUM
aiua-12464	3	30	)	)	PUNCT
aiua-12464	3	31	.	.	PUNCT
aiua-12464	4	1	mainly	mainly	ADV
aiua-12464	4	2	cbavd	cbavd	NOUN
aiua-12464	4	3	is	be	AUX
aiua-12464	4	4	diagnosed	diagnose	VERB
aiua-12464	4	5	at	at	ADP
aiua-12464	4	6	adulthood	adulthood	NOUN
aiua-12464	4	7	during	during	ADP
aiua-12464	4	8	a	a	DET
aiua-12464	4	9	medical	medical	ADJ
aiua-12464	4	10	examination	examination	NOUN
aiua-12464	4	11	for	for	ADP
aiua-12464	4	12	the	the	DET
aiua-12464	4	13	exploration	exploration	NOUN
aiua-12464	4	14	of	of	ADP
aiua-12464	4	15	infertility	infertility	NOUN
aiua-12464	4	16	.	.	PUNCT
aiua-12464	5	1	therefore	therefore	ADV
aiua-12464	5	2	,	,	PUNCT
aiua-12464	5	3	it	it	PRON
aiua-12464	5	4	is	be	AUX
aiua-12464	5	5	of	of	ADP
aiua-12464	5	6	prime	prime	ADJ
aiua-12464	5	7	importance	importance	NOUN
aiua-12464	5	8	to	to	PART
aiua-12464	5	9	properly	properly	ADV
aiua-12464	5	10	assess	assess	VERB
aiua-12464	5	11	infertile	infertile	ADJ
aiua-12464	5	12	men	man	NOUN
aiua-12464	5	13	with	with	ADP
aiua-12464	5	14	appropriate	appropriate	ADJ
aiua-12464	5	15	clinical	clinical	ADJ
aiua-12464	5	16	work	work	NOUN
aiua-12464	5	17	-	-	PUNCT
aiua-12464	5	18	up	up	NOUN
aiua-12464	5	19	,	,	PUNCT
aiua-12464	5	20	to	to	PART
aiua-12464	5	21	correctly	correctly	ADV
aiua-12464	5	22	address	address	VERB
aiua-12464	5	23	the	the	DET
aiua-12464	5	24	suitable	suitable	ADJ
aiua-12464	5	25	genetic	genetic	ADJ
aiua-12464	5	26	tests	test	NOUN
aiua-12464	5	27	in	in	ADP
aiua-12464	5	28	an	an	DET
aiua-12464	5	29	exclusive	exclusive	ADJ
aiua-12464	5	30	way	way	NOUN
aiua-12464	5	31	(	(	PUNCT
aiua-12464	5	32	4	4	NUM
aiua-12464	5	33	)	)	PUNCT
aiua-12464	5	34	.	.	PUNCT
aiua-12464	6	1	initially	initially	ADV
aiua-12464	6	2	,	,	PUNCT
aiua-12464	6	3	clinical	clinical	ADJ
aiua-12464	6	4	diagnosis	diagnosis	NOUN
aiua-12464	6	5	was	be	AUX
aiua-12464	6	6	made	make	VERB
aiua-12464	6	7	on	on	ADP
aiua-12464	6	8	the	the	DET
aiua-12464	6	9	palpation	palpation	NOUN
aiua-12464	6	10	of	of	ADP
aiua-12464	6	11	the	the	DET
aiua-12464	6	12	vas	vas	X
aiua-12464	6	13	deferens	deferens	PROPN
aiua-12464	6	14	(	(	PUNCT
aiua-12464	6	15	vd	vd	NOUN
aiua-12464	6	16	)	)	PUNCT
aiua-12464	6	17	,	,	PUNCT
aiua-12464	6	18	that	that	ADV
aiua-12464	6	19	is	is	ADV
aiua-12464	6	20	,	,	PUNCT
aiua-12464	6	21	on	on	ADP
aiua-12464	6	22	their	their	PRON
aiua-12464	6	23	intrascrotal	intrascrotal	ADJ
aiua-12464	6	24	portion	portion	NOUN
aiua-12464	6	25	:	:	PUNCT
aiua-12464	6	26	the	the	DET
aiua-12464	6	27	diagnosis	diagnosis	NOUN
aiua-12464	6	28	was	be	AUX
aiua-12464	6	29	negative	negative	ADJ
aiua-12464	6	30	if	if	SCONJ
aiua-12464	6	31	this	this	DET
aiua-12464	6	32	portion	portion	NOUN
aiua-12464	6	33	was	be	AUX
aiua-12464	6	34	present	present	ADJ
aiua-12464	6	35	and	and	CCONJ
aiua-12464	6	36	positive	positive	ADJ
aiua-12464	6	37	if	if	SCONJ
aiua-12464	6	38	it	it	PRON
aiua-12464	6	39	was	be	AUX
aiua-12464	6	40	absent	absent	ADJ
aiua-12464	6	41	.	.	PUNCT
aiua-12464	7	1	but	but	CCONJ
aiua-12464	7	2	in	in	ADP
aiua-12464	7	3	recent	recent	ADJ
aiua-12464	7	4	times	time	NOUN
aiua-12464	7	5	,	,	PUNCT
aiua-12464	7	6	besides	besides	SCONJ
aiua-12464	7	7	palpation	palpation	NOUN
aiua-12464	7	8	,	,	PUNCT
aiua-12464	7	9	ultrasound	ultrasound	NOUN
aiua-12464	7	10	imaging	imaging	NOUN
aiua-12464	7	11	(	(	PUNCT
aiua-12464	7	12	transrectal	transrectal	ADJ
aiua-12464	7	13	and	and	CCONJ
aiua-12464	7	14	scrotal	scrotal	ADJ
aiua-12464	7	15	)	)	PUNCT
aiua-12464	7	16	is	be	AUX
aiua-12464	7	17	essential	essential	ADJ
aiua-12464	7	18	for	for	ADP
aiua-12464	7	19	accurate	accurate	ADJ
aiua-12464	7	20	diagnosis	diagnosis	NOUN
aiua-12464	7	21	(	(	PUNCT
aiua-12464	7	22	5	5	NUM
aiua-12464	7	23	)	)	PUNCT
aiua-12464	7	24	.	.	PUNCT
aiua-12464	8	1	the	the	DET
aiua-12464	8	2	biological	biological	ADJ
aiua-12464	8	3	alarming	alarming	ADJ
aiua-12464	8	4	signal	signal	NOUN
aiua-12464	8	5	is	be	AUX
aiua-12464	8	6	a	a	DET
aiua-12464	8	7	nonpathognomonic	nonpathognomonic	ADJ
aiua-12464	8	8	trio	trio	NOUN
aiua-12464	8	9	:	:	PUNCT
aiua-12464	8	10	hypospermia	hypospermia	NOUN
aiua-12464	8	11	(	(	PUNCT
aiua-12464	8	12	semen	semen	NOUN
aiua-12464	8	13	volume	volume	NOUN
aiua-12464	8	14	<	<	X
aiua-12464	8	15	1.5	1.5	NUM
aiua-12464	8	16	ml	ml	NOUN
aiua-12464	8	17	)	)	PUNCT
aiua-12464	8	18	,	,	PUNCT
aiua-12464	8	19	the	the	DET
aiua-12464	8	20	value	value	NOUN
aiua-12464	8	21	of	of	ADP
aiua-12464	8	22	seminal	seminal	ADJ
aiua-12464	8	23	plasma	plasma	NOUN
aiua-12464	8	24	lesser	less	ADJ
aiua-12464	8	25	than	than	ADP
aiua-12464	8	26	the	the	DET
aiua-12464	8	27	reference	reference	NOUN
aiua-12464	8	28	level	level	NOUN
aiua-12464	8	29	(	(	PUNCT
aiua-12464	8	30	fructose	fructose	NOUN
aiua-12464	8	31	<	<	X
aiua-12464	8	32	13	13	NUM
aiua-12464	8	33	μmol	μmol	NOUN
aiua-12464	8	34	/	/	SYM
aiua-12464	8	35	ejaculate	ejaculate	NOUN
aiua-12464	8	36	;	;	PUNCT
aiua-12464	8	37	glycerophosphocholine	glycerophosphocholine	NOUN
aiua-12464	8	38	(	(	PUNCT
aiua-12464	8	39	gpc	gpc	PROPN
aiua-12464	8	40	)	)	PUNCT
aiua-12464	8	41	<	<	X
aiua-12464	8	42	2	2	NUM
aiua-12464	8	43	µmol	µmol	ADV
aiua-12464	8	44	/	/	SYM
aiua-12464	8	45	ejaculate	ejaculate	NOUN
aiua-12464	8	46	)	)	PUNCT
aiua-12464	8	47	,	,	PUNCT
aiua-12464	8	48	and	and	CCONJ
aiua-12464	8	49	acid	acid	ADJ
aiua-12464	8	50	ph	ph	NOUN
aiua-12464	8	51	(	(	PUNCT
aiua-12464	8	52	<	<	X
aiua-12464	8	53	7.0	7.0	NUM
aiua-12464	8	54	)	)	PUNCT
aiua-12464	8	55	(	(	PUNCT
aiua-12464	8	56	6	6	NUM
aiua-12464	8	57	)	)	PUNCT
aiua-12464	8	58	.	.	PUNCT
aiua-12464	9	1	hence	hence	ADV
aiua-12464	9	2	,	,	PUNCT
aiua-12464	9	3	on	on	ADP
aiua-12464	9	4	the	the	DET
aiua-12464	9	5	basis	basis	NOUN
aiua-12464	9	6	of	of	ADP
aiua-12464	9	7	clinical	clinical	ADJ
aiua-12464	9	8	symptoms	symptom	NOUN
aiua-12464	9	9	,	,	PUNCT
aiua-12464	9	10	two	two	NUM
aiua-12464	9	11	clinical	clinical	ADJ
aiua-12464	9	12	categories	category	NOUN
aiua-12464	9	13	of	of	ADP
aiua-12464	9	14	cbavd	cbavd	NOUN
aiua-12464	9	15	have	have	AUX
aiua-12464	9	16	been	be	AUX
aiua-12464	9	17	reported	report	VERB
aiua-12464	9	18	:	:	PUNCT
aiua-12464	9	19	cbavd	cbavd	NOUN
aiua-12464	9	20	showing	show	VERB
aiua-12464	9	21	symptoms	symptom	NOUN
aiua-12464	9	22	of	of	ADP
aiua-12464	9	23	cystic	cystic	ADJ
aiua-12464	9	24	fibrosis	fibrosis	NOUN
aiua-12464	9	25	referred	refer	VERB
aiua-12464	9	26	as	as	ADP
aiua-12464	9	27	cf	cf	NOUN
aiua-12464	9	28	-	-	PUNCT
aiua-12464	9	29	cbavd	cbavd	NOUN
aiua-12464	9	30	and	and	CCONJ
aiua-12464	9	31	cbavd	cbavd	NOUN
aiua-12464	9	32	without	without	ADP
aiua-12464	9	33	clinical	clinical	ADJ
aiua-12464	9	34	symptoms	symptom	NOUN
aiua-12464	9	35	of	of	ADP
aiua-12464	9	36	cf	cf	NOUN
aiua-12464	9	37	referred	refer	VERB
aiua-12464	9	38	as	as	ADP
aiua-12464	9	39	isolated	isolated	ADJ
aiua-12464	9	40	cbavd	cbavd	NOUN
aiua-12464	9	41	(	(	PUNCT
aiua-12464	9	42	icbavd	icbavd	PROPN
aiua-12464	9	43	)	)	PUNCT
aiua-12464	9	44	(	(	PUNCT
aiua-12464	9	45	7	7	NUM
aiua-12464	9	46	)	)	PUNCT
aiua-12464	9	47	.	.	PUNCT
aiua-12464	10	1	furthermore	furthermore	ADV
aiua-12464	10	2	,	,	PUNCT
aiua-12464	10	3	apart	apart	ADV
aiua-12464	10	4	from	from	ADP
aiua-12464	10	5	cf	cf	NOUN
aiua-12464	10	6	associated	associated	ADJ
aiua-12464	10	7	symptoms	symptom	NOUN
aiua-12464	10	8	,	,	PUNCT
aiua-12464	10	9	other	other	ADJ
aiua-12464	10	10	congenital	congenital	ADJ
aiua-12464	10	11	genitourinary	genitourinary	ADJ
aiua-12464	10	12	defects	defect	NOUN
aiua-12464	10	13	,	,	PUNCT
aiua-12464	10	14	primarily	primarily	ADV
aiua-12464	10	15	including	include	VERB
aiua-12464	10	16	dysplasia	dysplasia	NOUN
aiua-12464	10	17	or	or	CCONJ
aiua-12464	10	18	the	the	DET
aiua-12464	10	19	absence	absence	NOUN
aiua-12464	10	20	of	of	ADP
aiua-12464	10	21	seminal	seminal	ADJ
aiua-12464	10	22	vesicles	vesicle	NOUN
aiua-12464	10	23	and	and	CCONJ
aiua-12464	10	24	kidney	kidney	NOUN
aiua-12464	10	25	-	-	PUNCT
aiua-12464	10	26	related	relate	VERB
aiua-12464	10	27	issues	issue	NOUN
aiua-12464	10	28	contributes	contribute	VERB
aiua-12464	10	29	towards	towards	ADP
aiua-12464	10	30	cbavd	cbavd	NOUN
aiua-12464	10	31	(	(	PUNCT
aiua-12464	10	32	8	8	NUM
aiua-12464	10	33	,	,	PUNCT
aiua-12464	10	34	9	9	NUM
aiua-12464	10	35	)	)	PUNCT
aiua-12464	10	36	.	.	PUNCT
aiua-12464	11	1	the	the	DET
aiua-12464	11	2	anatomical	anatomical	ADJ
aiua-12464	11	3	anomalies	anomaly	NOUN
aiua-12464	11	4	related	relate	VERB
aiua-12464	11	5	to	to	ADP
aiua-12464	11	6	cbavd	cbavd	NOUN
aiua-12464	11	7	occur	occur	VERB
aiua-12464	11	8	at	at	ADP
aiua-12464	11	9	the	the	DET
aiua-12464	11	10	embryonic	embryonic	ADJ
aiua-12464	11	11	stage	stage	NOUN
aiua-12464	11	12	.	.	PUNCT
aiua-12464	12	1	cystic	cystic	ADJ
aiua-12464	12	2	fibrosis	fibrosis	NOUN
aiua-12464	12	3	transmembrane	transmembrane	NOUN
aiua-12464	12	4	conductance	conductance	NOUN
aiua-12464	12	5	regulator	regulator	NOUN
aiua-12464	12	6	gene	gene	NOUN
aiua-12464	12	7	(	(	PUNCT
aiua-12464	12	8	cftr	cftr	NOUN
aiua-12464	12	9	)	)	PUNCT
aiua-12464	12	10	or	or	CCONJ
aiua-12464	12	11	cftr	cftr	NOUN
aiua-12464	12	12	mediated	mediate	VERB
aiua-12464	12	13	anions	anion	NOUN
aiua-12464	12	14	are	be	AUX
aiua-12464	12	15	essential	essential	ADJ
aiua-12464	12	16	for	for	ADP
aiua-12464	12	17	normal	normal	ADJ
aiua-12464	12	18	growth	growth	NOUN
aiua-12464	12	19	of	of	ADP
aiua-12464	12	20	the	the	DET
aiua-12464	12	21	male	male	ADJ
aiua-12464	12	22	reproductive	reproductive	ADJ
aiua-12464	12	23	tract	tract	NOUN
aiua-12464	12	24	(	(	PUNCT
aiua-12464	12	25	10	10	NUM
aiua-12464	12	26	)	)	PUNCT
aiua-12464	12	27	.	.	PUNCT
aiua-12464	13	1	mutations	mutation	NOUN
aiua-12464	13	2	in	in	ADP
aiua-12464	13	3	the	the	DET
aiua-12464	13	4	cftr	cftr	NOUN
aiua-12464	13	5	gene	gene	NOUN
aiua-12464	13	6	have	have	VERB
aiua-12464	13	7	a	a	DET
aiua-12464	13	8	crucial	crucial	ADJ
aiua-12464	13	9	impact	impact	NOUN
aiua-12464	13	10	on	on	ADP
aiua-12464	13	11	the	the	DET
aiua-12464	13	12	vas	vas	X
aiua-12464	13	13	deferens	deferens	PROPN
aiua-12464	13	14	development	development	NOUN
aiua-12464	13	15	in	in	ADP
aiua-12464	13	16	fetuses	fetus	NOUN
aiua-12464	13	17	aged	age	VERB
aiua-12464	13	18	12	12	NUM
aiua-12464	13	19	-	-	SYM
aiua-12464	13	20	18	18	NUM
aiua-12464	13	21	weeks	week	NOUN
aiua-12464	13	22	(	(	PUNCT
aiua-12464	13	23	11	11	NUM
aiua-12464	13	24	)	)	PUNCT
aiua-12464	13	25	.	.	PUNCT
aiua-12464	14	1	these	these	DET
aiua-12464	14	2	mutations	mutation	NOUN
aiua-12464	14	3	lead	lead	VERB
aiua-12464	14	4	to	to	ADP
aiua-12464	14	5	obstructions	obstruction	NOUN
aiua-12464	14	6	and	and	CCONJ
aiua-12464	14	7	denaturation	denaturation	NOUN
aiua-12464	14	8	of	of	ADP
aiua-12464	14	9	the	the	DET
aiua-12464	14	10	vas	vas	X
aiua-12464	14	11	deferens	deferens	NOUN
aiua-12464	14	12	due	due	ADJ
aiua-12464	14	13	to	to	ADP
aiua-12464	14	14	mucus	mucus	NOUN
aiua-12464	14	15	accumulation	accumulation	NOUN
aiua-12464	14	16	,	,	PUNCT
aiua-12464	14	17	particularly	particularly	ADV
aiua-12464	14	18	pronounced	pronounce	VERB
aiua-12464	14	19	during	during	ADP
aiua-12464	14	20	embryonic	embryonic	ADJ
aiua-12464	14	21	growth	growth	NOUN
aiua-12464	14	22	.	.	PUNCT
aiua-12464	15	1	studies	study	NOUN
aiua-12464	15	2	showed	show	VERB
aiua-12464	15	3	that	that	SCONJ
aiua-12464	15	4	proper	proper	ADJ
aiua-12464	15	5	fluid	fluid	ADJ
aiua-12464	15	6	secretion	secretion	NOUN
aiua-12464	15	7	is	be	AUX
aiua-12464	15	8	crucial	crucial	ADJ
aiua-12464	15	9	for	for	SCONJ
aiua-12464	15	10	the	the	DET
aiua-12464	15	11	mesonephric	mesonephric	ADJ
aiua-12464	15	12	duct	duct	NOUN
aiua-12464	15	13	to	to	PART
aiua-12464	15	14	develop	develop	VERB
aiua-12464	15	15	correctly	correctly	ADV
aiua-12464	15	16	(	(	PUNCT
aiua-12464	15	17	12	12	NUM
aiua-12464	15	18	,	,	PUNCT
aiua-12464	15	19	congenital	congenital	ADJ
aiua-12464	15	20	bilateral	bilateral	ADJ
aiua-12464	15	21	absence	absence	NOUN
aiua-12464	15	22	of	of	ADP
aiua-12464	15	23	vas	vas	X
aiua-12464	15	24	deferens	deferens	PROPN
aiua-12464	15	25	(	(	PUNCT
aiua-12464	15	26	cbavd	cbavd	NOUN
aiua-12464	15	27	)	)	PUNCT
aiua-12464	15	28	is	be	AUX
aiua-12464	15	29	a	a	DET
aiua-12464	15	30	urological	urological	ADJ
aiua-12464	15	31	syndrome	syndrome	NOUN
aiua-12464	15	32	of	of	ADP
aiua-12464	15	33	wolffian	wolffian	ADJ
aiua-12464	15	34	ducts	duct	NOUN
aiua-12464	15	35	and	and	CCONJ
aiua-12464	15	36	is	be	AUX
aiua-12464	15	37	responsible	responsible	ADJ
aiua-12464	15	38	for	for	ADP
aiua-12464	15	39	male	male	ADJ
aiua-12464	15	40	infertility	infertility	NOUN
aiua-12464	15	41	and	and	CCONJ
aiua-12464	15	42	obstructive	obstructive	ADJ
aiua-12464	15	43	azoospermia	azoospermia	NOUN
aiua-12464	15	44	.	.	PUNCT
aiua-12464	16	1	this	this	DET
aiua-12464	16	2	study	study	NOUN
aiua-12464	16	3	is	be	AUX
aiua-12464	16	4	designed	design	VERB
aiua-12464	16	5	to	to	PART
aiua-12464	16	6	explore	explore	VERB
aiua-12464	16	7	the	the	DET
aiua-12464	16	8	integrity	integrity	NOUN
aiua-12464	16	9	of	of	ADP
aiua-12464	16	10	exon	exon	PROPN
aiua-12464	16	11	10	10	NUM
aiua-12464	16	12	of	of	ADP
aiua-12464	16	13	cftr	cftr	NOUN
aiua-12464	16	14	and	and	CCONJ
aiua-12464	16	15	its	its	PRON
aiua-12464	16	16	role	role	NOUN
aiua-12464	16	17	in	in	ADP
aiua-12464	16	18	male	male	ADJ
aiua-12464	16	19	infertility	infertility	NOUN
aiua-12464	16	20	in	in	ADP
aiua-12464	16	21	a	a	DET
aiua-12464	16	22	cohort	cohort	NOUN
aiua-12464	16	23	of	of	ADP
aiua-12464	16	24	cbvad	cbvad	NOUN
aiua-12464	16	25	patients	patient	NOUN
aiua-12464	16	26	in	in	ADP
aiua-12464	16	27	pakistan	pakistan	PROPN
aiua-12464	16	28	.	.	PUNCT
aiua-12464	17	1	genomic	genomic	PROPN
aiua-12464	17	2	dna	dna	PROPN
aiua-12464	17	3	was	be	AUX
aiua-12464	17	4	extracted	extract	VERB
aiua-12464	17	5	from	from	ADP
aiua-12464	17	6	17	17	NUM
aiua-12464	17	7	male	male	ADJ
aiua-12464	17	8	patients	patient	NOUN
aiua-12464	17	9	with	with	ADP
aiua-12464	17	10	cbavd	cbavd	NOUN
aiua-12464	17	11	having	have	VERB
aiua-12464	17	12	clinical	clinical	ADJ
aiua-12464	17	13	symptoms	symptom	NOUN
aiua-12464	17	14	,	,	PUNCT
aiua-12464	17	15	and	and	CCONJ
aiua-12464	17	16	10	10	NUM
aiua-12464	17	17	healthy	healthy	ADJ
aiua-12464	17	18	controls	control	NOUN
aiua-12464	17	19	via	via	ADP
aiua-12464	17	20	phenol	phenol	NOUN
aiua-12464	17	21	-	-	PUNCT
aiua-12464	17	22	chloroform	chloroform	NOUN
aiua-12464	17	23	method	method	NOUN
aiua-12464	17	24	.	.	PUNCT
aiua-12464	18	1	exon	exon	PROPN
aiua-12464	18	2	10	10	NUM
aiua-12464	18	3	of	of	ADP
aiua-12464	18	4	the	the	DET
aiua-12464	18	5	cftr	cftr	NOUN
aiua-12464	18	6	gene	gene	NOUN
aiua-12464	18	7	was	be	AUX
aiua-12464	18	8	amplified	amplify	VERB
aiua-12464	18	9	,	,	PUNCT
aiua-12464	18	10	using	use	VERB
aiua-12464	18	11	pcr	pcr	NOUN
aiua-12464	18	12	with	with	ADP
aiua-12464	18	13	specific	specific	ADJ
aiua-12464	18	14	primers	primer	NOUN
aiua-12464	18	15	and	and	CCONJ
aiua-12464	18	16	dna	dna	PROPN
aiua-12464	18	17	screening	screening	NOUN
aiua-12464	18	18	was	be	AUX
aiua-12464	18	19	done	do	VERB
aiua-12464	18	20	by	by	ADP
aiua-12464	18	21	sanger	sanger	PROPN
aiua-12464	18	22	sequencing	sequencing	NOUN
aiua-12464	18	23	.	.	PUNCT
aiua-12464	19	1	sequencing	sequence	VERB
aiua-12464	19	2	results	result	NOUN
aiua-12464	19	3	were	be	AUX
aiua-12464	19	4	analyzed	analyze	VERB
aiua-12464	19	5	using	use	VERB
aiua-12464	19	6	freeware	freeware	NOUN
aiua-12464	19	7	serial	serial	ADJ
aiua-12464	19	8	cloner	cloner	NOUN
aiua-12464	19	9	,	,	PUNCT
aiua-12464	19	10	snapgene	snapgene	NOUN
aiua-12464	19	11	,	,	PUNCT
aiua-12464	19	12	bioedit	bioedit	NOUN
aiua-12464	19	13	and	and	CCONJ
aiua-12464	19	14	finchtv	finchtv	ADJ
aiua-12464	19	15	.	.	PUNCT
aiua-12464	20	1	furthermore	furthermore	ADV
aiua-12464	20	2	,	,	PUNCT
aiua-12464	20	3	bioinformatics	bioinformatics	NOUN
aiua-12464	20	4	tools	tool	NOUN
aiua-12464	20	5	were	be	AUX
aiua-12464	20	6	used	use	VERB
aiua-12464	20	7	to	to	PART
aiua-12464	20	8	analyze	analyze	VERB
aiua-12464	20	9	the	the	DET
aiua-12464	20	10	mutations	mutation	NOUN
aiua-12464	20	11	and	and	CCONJ
aiua-12464	20	12	their	their	PRON
aiua-12464	20	13	impact	impact	NOUN
aiua-12464	20	14	on	on	ADP
aiua-12464	20	15	the	the	DET
aiua-12464	20	16	protein	protein	NOUN
aiua-12464	20	17	function	function	NOUN
aiua-12464	20	18	and	and	CCONJ
aiua-12464	20	19	stability	stability	NOUN
aiua-12464	20	20	.	.	PUNCT
aiua-12464	21	1	we	we	PRON
aiua-12464	21	2	have	have	AUX
aiua-12464	21	3	identified	identify	VERB
aiua-12464	21	4	4	4	NUM
aiua-12464	21	5	mutations	mutation	NOUN
aiua-12464	21	6	on	on	ADP
aiua-12464	21	7	exon	exon	NOUN
aiua-12464	21	8	10	10	NUM
aiua-12464	21	9	of	of	ADP
aiua-12464	21	10	cftr	cftr	NOUN
aiua-12464	21	11	in	in	ADP
aiua-12464	21	12	6	6	NUM
aiua-12464	21	13	out	out	ADP
aiua-12464	21	14	of	of	ADP
aiua-12464	21	15	17	17	NUM
aiua-12464	21	16	patients	patient	NOUN
aiua-12464	21	17	.	.	PUNCT
aiua-12464	22	1	two	two	NUM
aiua-12464	22	2	of	of	ADP
aiua-12464	22	3	the	the	DET
aiua-12464	22	4	mutations	mutation	NOUN
aiua-12464	22	5	were	be	AUX
aiua-12464	22	6	missense	missense	NOUN
aiua-12464	22	7	variants	variant	NOUN
aiua-12464	22	8	v456a	v456a	PROPN
aiua-12464	22	9	,	,	PUNCT
aiua-12464	22	10	k464e	k464e	PROPN
aiua-12464	22	11	,	,	PUNCT
aiua-12464	22	12	and	and	CCONJ
aiua-12464	22	13	the	the	DET
aiua-12464	22	14	other	other	ADJ
aiua-12464	22	15	two	two	NUM
aiua-12464	22	16	were	be	AUX
aiua-12464	22	17	silent	silent	ADJ
aiua-12464	22	18	mutations	mutation	NOUN
aiua-12464	22	19	g437	g437	PROPN
aiua-12464	22	20	g	g	NOUN
aiua-12464	22	21	,	,	PUNCT
aiua-12464	22	22	s431s	s431s	NUM
aiua-12464	22	23	.	.	PUNCT
aiua-12464	23	1	the	the	DET
aiua-12464	23	2	identified	identify	VERB
aiua-12464	23	3	variant	variant	NOUN
aiua-12464	23	4	v456a	v456a	PROPN
aiua-12464	23	5	was	be	AUX
aiua-12464	23	6	present	present	ADJ
aiua-12464	23	7	in	in	ADP
aiua-12464	23	8	4	4	NUM
aiua-12464	23	9	of	of	ADP
aiua-12464	23	10	the	the	DET
aiua-12464	23	11	studied	studied	ADJ
aiua-12464	23	12	patients	patient	NOUN
aiua-12464	23	13	.	.	PUNCT
aiua-12464	24	1	whereas	whereas	SCONJ
aiua-12464	24	2	,	,	PUNCT
aiua-12464	24	3	the	the	DET
aiua-12464	24	4	presence	presence	NOUN
aiua-12464	24	5	of	of	ADP
aiua-12464	24	6	k464e	k464e	PROPN
aiua-12464	24	7	in	in	ADP
aiua-12464	24	8	our	our	PRON
aiua-12464	24	9	patients	patient	NOUN
aiua-12464	24	10	further	far	ADV
aiua-12464	24	11	weighs	weigh	VERB
aiua-12464	24	12	on	on	ADP
aiua-12464	24	13	the	the	DET
aiua-12464	24	14	crucial	crucial	ADJ
aiua-12464	24	15	importance	importance	NOUN
aiua-12464	24	16	for	for	ADP
aiua-12464	24	17	its	its	PRON
aiua-12464	24	18	strategic	strategic	ADJ
aiua-12464	24	19	location	location	NOUN
aiua-12464	24	20	to	to	PART
aiua-12464	24	21	influence	influence	VERB
aiua-12464	24	22	the	the	DET
aiua-12464	24	23	gene	gene	NOUN
aiua-12464	24	24	function	function	NOUN
aiua-12464	24	25	at	at	ADP
aiua-12464	24	26	post	post	ADJ
aiua-12464	24	27	-	-	ADJ
aiua-12464	24	28	transcriptional	transcriptional	ADJ
aiua-12464	24	29	and	and	CCONJ
aiua-12464	24	30	protein	protein	NOUN
aiua-12464	24	31	level	level	NOUN
aiua-12464	24	32	.	.	PUNCT
aiua-12464	25	1	furthermore	furthermore	ADV
aiua-12464	25	2	,	,	PUNCT
aiua-12464	25	3	polyphen-2	polyphen-2	X
aiua-12464	25	4	and	and	CCONJ
aiua-12464	25	5	sift	sift	VERB
aiua-12464	25	6	analyze	analyze	VERB
aiua-12464	25	7	the	the	DET
aiua-12464	25	8	mutations	mutation	NOUN
aiua-12464	25	9	as	as	ADP
aiua-12464	25	10	harmful	harmful	ADJ
aiua-12464	25	11	and	and	CCONJ
aiua-12464	25	12	deleterious	deleterious	ADJ
aiua-12464	25	13	.	.	PUNCT
aiua-12464	26	1	the	the	DET
aiua-12464	26	2	recurrence	recurrence	NOUN
aiua-12464	26	3	of	of	ADP
aiua-12464	26	4	v456a	v456a	PROPN
aiua-12464	26	5	and	and	CCONJ
aiua-12464	26	6	tactically	tactically	ADV
aiua-12464	26	7	conserved	conserve	VERB
aiua-12464	26	8	locality	locality	NOUN
aiua-12464	26	9	of	of	ADP
aiua-12464	26	10	k464e	k464e	PROPN
aiua-12464	26	11	are	be	AUX
aiua-12464	26	12	evidence	evidence	NOUN
aiua-12464	26	13	of	of	ADP
aiua-12464	26	14	their	their	PRON
aiua-12464	26	15	potential	potential	ADJ
aiua-12464	26	16	role	role	NOUN
aiua-12464	26	17	in	in	ADP
aiua-12464	26	18	cbavd	cbavd	ADJ
aiua-12464	26	19	patients	patient	NOUN
aiua-12464	26	20	and	and	CCONJ
aiua-12464	26	21	in	in	ADP
aiua-12464	26	22	male	male	ADJ
aiua-12464	26	23	infertility	infertility	NOUN
aiua-12464	26	24	.	.	PUNCT
aiua-12464	27	1	the	the	DET
aiua-12464	27	2	data	datum	NOUN
aiua-12464	27	3	can	can	AUX
aiua-12464	27	4	contribute	contribute	VERB
aiua-12464	27	5	in	in	ADP
aiua-12464	27	6	developing	develop	VERB
aiua-12464	27	7	genetic	genetic	ADJ
aiua-12464	27	8	testing	testing	NOUN
aiua-12464	27	9	and	and	CCONJ
aiua-12464	27	10	treatment	treatment	NOUN
aiua-12464	27	11	of	of	ADP
aiua-12464	27	12	cbavd	cbavd	NOUN
aiua-12464	27	13	.	.	PUNCT
aiua-12464	28	1	key	key	ADJ
aiua-12464	28	2	words	word	NOUN
aiua-12464	28	3	:	:	PUNCT
aiua-12464	28	4	cftr	cftr	NOUN
aiua-12464	28	5	;	;	PUNCT
aiua-12464	28	6	cbavd	cbavd	NOUN
aiua-12464	28	7	;	;	PUNCT
aiua-12464	28	8	exon	exon	NOUN
aiua-12464	28	9	10	10	NUM
aiua-12464	28	10	;	;	PUNCT
aiua-12464	28	11	mutation	mutation	NOUN
aiua-12464	28	12	analysis	analysis	NOUN
aiua-12464	28	13	;	;	PUNCT
aiua-12464	28	14	missense	missense	NOUN
aiua-12464	28	15	mutations	mutation	NOUN
aiua-12464	28	16	.	.	PUNCT
aiua-12464	28	17	submitted	submit	VERB
aiua-12464	28	18	8	8	NUM
aiua-12464	28	19	march	march	NOUN
aiua-12464	28	20	2024	2024	NUM
aiua-12464	28	21	;	;	PUNCT
aiua-12464	28	22	accepted	accept	VERB
aiua-12464	28	23	15	15	NUM
aiua-12464	28	24	april	april	PROPN
aiua-12464	28	25	2024	2024	NUM
aiua-12464	28	26	introduction	introduction	NOUN
aiua-12464	28	27	congenital	congenital	ADJ
aiua-12464	28	28	absence	absence	NOUN
aiua-12464	28	29	of	of	ADP
aiua-12464	28	30	vas	vas	X
aiua-12464	28	31	deferens	deferens	PROPN
aiua-12464	28	32	(	(	PUNCT
aiua-12464	28	33	cavd	cavd	NOUN
aiua-12464	28	34	)	)	PUNCT
aiua-12464	28	35	is	be	AUX
aiua-12464	28	36	a	a	DET
aiua-12464	28	37	urological	urological	ADJ
aiua-12464	28	38	syndrome	syndrome	NOUN
aiua-12464	28	39	presumably	presumably	ADV
aiua-12464	28	40	resulting	result	VERB
aiua-12464	28	41	in	in	ADP
aiua-12464	28	42	abnormalities	abnormality	NOUN
aiua-12464	28	43	of	of	ADP
aiua-12464	28	44	the	the	DET
aiua-12464	28	45	wolffian	wolffian	ADJ
aiua-12464	28	46	ducts	duct	NOUN
aiua-12464	28	47	.	.	PUNCT
aiua-12464	29	1	it	it	PRON
aiua-12464	29	2	is	be	AUX
aiua-12464	29	3	also	also	ADV
aiua-12464	29	4	a	a	DET
aiua-12464	29	5	contributing	contribute	VERB
aiua-12464	29	6	factor	factor	NOUN
aiua-12464	29	7	to	to	ADP
aiua-12464	29	8	obstructive	obstructive	ADJ
aiua-12464	29	9	azoospermia	azoospermia	NOUN
aiua-12464	29	10	.	.	PUNCT
aiua-12464	30	1	it	it	PRON
aiua-12464	30	2	is	be	AUX
aiua-12464	30	3	categorized	categorize	VERB
aiua-12464	30	4	into	into	ADP
aiua-12464	30	5	three	three	NUM
aiua-12464	30	6	types	type	NOUN
aiua-12464	30	7	:	:	PUNCT
aiua-12464	30	8	unilateral	unilateral	ADJ
aiua-12464	30	9	(	(	PUNCT
aiua-12464	30	10	cuavd	cuavd	NOUN
aiua-12464	30	11	)	)	PUNCT
aiua-12464	30	12	,	,	PUNCT
aiua-12464	30	13	bilateral	bilateral	ADJ
aiua-12464	30	14	(	(	PUNCT
aiua-12464	30	15	cbavd	cbavd	NOUN
aiua-12464	30	16	)	)	PUNCT
aiua-12464	30	17	,	,	PUNCT
aiua-12464	30	18	and	and	CCONJ
aiua-12464	30	19	congenital	congenital	ADJ
aiua-12464	30	20	bilateral	bilateral	ADJ
aiua-12464	30	21	partial	partial	ADJ
aiua-12464	30	22	aplasia	aplasia	NOUN
aiua-12464	30	23	(	(	PUNCT
aiua-12464	30	24	cpavd	cpavd	PROPN
aiua-12464	30	25	)	)	PUNCT
aiua-12464	30	26	(	(	PUNCT
aiua-12464	30	27	1	1	NUM
aiua-12464	30	28	)	)	PUNCT
aiua-12464	30	29	.	.	PUNCT
aiua-12464	31	1	cbavd	cbavd	PROPN
aiua-12464	31	2	is	be	AUX
aiua-12464	31	3	the	the	DET
aiua-12464	31	4	most	most	ADV
aiua-12464	31	5	prevalent	prevalent	ADJ
aiua-12464	31	6	subtype	subtype	NOUN
aiua-12464	31	7	that	that	PRON
aiua-12464	31	8	follows	follow	VERB
aiua-12464	31	9	an	an	DET
aiua-12464	31	10	autosomal	autosomal	ADJ
aiua-12464	31	11	recessive	recessive	ADJ
aiua-12464	31	12	pattern	pattern	NOUN
aiua-12464	31	13	and	and	CCONJ
aiua-12464	31	14	accounts	account	VERB
aiua-12464	31	15	for	for	SCONJ
aiua-12464	31	16	1	1	NUM
aiua-12464	31	17	-	-	SYM
aiua-12464	31	18	2	2	NUM
aiua-12464	31	19	%	%	NOUN
aiua-12464	31	20	of	of	ADP
aiua-12464	31	21	cftr	cftr	PROPN
aiua-12464	31	22	exon	exon	PROPN
aiua-12464	31	23	10	10	NUM
aiua-12464	31	24	deleterious	deleterious	ADJ
aiua-12464	31	25	mutations	mutation	NOUN
aiua-12464	31	26	in	in	ADP
aiua-12464	31	27	patients	patient	NOUN
aiua-12464	31	28	with	with	ADP
aiua-12464	31	29	congenital	congenital	ADJ
aiua-12464	31	30	bilateral	bilateral	ADJ
aiua-12464	31	31	absence	absence	NOUN
aiua-12464	31	32	of	of	ADP
aiua-12464	31	33	vas	vas	X
aiua-12464	31	34	deferens	deferens	NOUN
aiua-12464	31	35	in	in	ADP
aiua-12464	31	36	a	a	DET
aiua-12464	31	37	cohort	cohort	NOUN
aiua-12464	31	38	of	of	ADP
aiua-12464	31	39	pakistani	pakistani	ADJ
aiua-12464	31	40	patients	patient	NOUN
aiua-12464	31	41	khush	khush	VERB
aiua-12464	31	42	bakhat	bakhat	DET
aiua-12464	31	43	1	1	NUM
aiua-12464	31	44	,	,	PUNCT
aiua-12464	31	45	irsa	irsa	PROPN
aiua-12464	31	46	mateen	mateen	PROPN
aiua-12464	31	47	2	2	NUM
aiua-12464	31	48	,	,	PUNCT
aiua-12464	31	49	hina	hina	NOUN
aiua-12464	31	50	saif	saif	PROPN
aiua-12464	31	51	3	3	NUM
aiua-12464	31	52	,	,	PUNCT
aiua-12464	31	53	kanwal	kanwal	PROPN
aiua-12464	31	54	anwar	anwar	PROPN
aiua-12464	31	55	1	1	NUM
aiua-12464	31	56	,	,	PUNCT
aiua-12464	31	57	sadaf	sadaf	NOUN
aiua-12464	31	58	sarfraz	sarfraz	PROPN
aiua-12464	31	59	1	1	NUM
aiua-12464	31	60	,	,	PUNCT
aiua-12464	31	61	sheza	sheza	PROPN
aiua-12464	31	62	javaid	javaid	VERB
aiua-12464	31	63	1	1	NUM
aiua-12464	31	64	,	,	PUNCT
aiua-12464	31	65	khaleeq	khaleeq	ADJ
aiua-12464	31	66	-	-	PUNCT
aiua-12464	31	67	ur	ur	INTJ
aiua-12464	31	68	-	-	NOUN
aiua-12464	31	69	rehman	rehman	NOUN
aiua-12464	31	70	4	4	NUM
aiua-12464	31	71	,	,	PUNCT
aiua-12464	31	72	adnan	adnan	PROPN
aiua-12464	31	73	arshad	arshad	PROPN
aiua-12464	31	74	1	1	NUM
aiua-12464	31	75	,	,	PUNCT
aiua-12464	31	76	muhammad	muhammad	PROPN
aiua-12464	31	77	mustafa	mustafa	PROPN
aiua-12464	31	78	1	1	NUM
aiua-12464	31	79	1	1	NUM
aiua-12464	31	80	kam	kam	NOUN
aiua-12464	31	81	school	school	NOUN
aiua-12464	31	82	of	of	ADP
aiua-12464	31	83	life	life	NOUN
aiua-12464	31	84	science	science	NOUN
aiua-12464	31	85	,	,	PUNCT
aiua-12464	31	86	forman	forman	PROPN
aiua-12464	31	87	christian	christian	PROPN
aiua-12464	31	88	college	college	PROPN
aiua-12464	31	89	,	,	PUNCT
aiua-12464	31	90	(	(	PUNCT
aiua-12464	31	91	a	a	DET
aiua-12464	31	92	chartered	chartered	ADJ
aiua-12464	31	93	university	university	NOUN
aiua-12464	31	94	)	)	PUNCT
aiua-12464	31	95	,	,	PUNCT
aiua-12464	31	96	lahore	lahore	NOUN
aiua-12464	31	97	,	,	PUNCT
aiua-12464	31	98	pakistan	pakistan	PROPN
aiua-12464	31	99	;	;	PUNCT
aiua-12464	31	100	2	2	NUM
aiua-12464	31	101	school	school	NOUN
aiua-12464	31	102	of	of	ADP
aiua-12464	31	103	biochemistry	biochemistry	NOUN
aiua-12464	31	104	,	,	PUNCT
aiua-12464	31	105	minhaj	minhaj	PROPN
aiua-12464	31	106	university	university	PROPN
aiua-12464	31	107	lahore	lahore	NOUN
aiua-12464	31	108	,	,	PUNCT
aiua-12464	31	109	lahore	lahore	NOUN
aiua-12464	31	110	,	,	PUNCT
aiua-12464	31	111	pakistan	pakistan	PROPN
aiua-12464	31	112	;	;	PUNCT
aiua-12464	31	113	3	3	NUM
aiua-12464	31	114	department	department	NOUN
aiua-12464	31	115	of	of	ADP
aiua-12464	31	116	emerging	emerge	VERB
aiua-12464	31	117	allied	ally	VERB
aiua-12464	31	118	health	health	NOUN
aiua-12464	31	119	technologies	technology	NOUN
aiua-12464	31	120	,	,	PUNCT
aiua-12464	31	121	university	university	NOUN
aiua-12464	31	122	of	of	ADP
aiua-12464	31	123	lahore	lahore	PROPN
aiua-12464	31	124	,	,	PUNCT
aiua-12464	31	125	pakistan	pakistan	PROPN
aiua-12464	31	126	;	;	PUNCT
aiua-12464	31	127	4	4	NUM
aiua-12464	31	128	department	department	NOUN
aiua-12464	31	129	of	of	ADP
aiua-12464	31	130	urology	urology	NOUN
aiua-12464	31	131	,	,	PUNCT
aiua-12464	31	132	fatima	fatima	PROPN
aiua-12464	31	133	memorial	memorial	PROPN
aiua-12464	31	134	hospital	hospital	PROPN
aiua-12464	31	135	college	college	PROPN
aiua-12464	31	136	of	of	ADP
aiua-12464	31	137	medicine	medicine	PROPN
aiua-12464	31	138	&	&	CCONJ
aiua-12464	31	139	dentistry	dentistry	PROPN
aiua-12464	31	140	,	,	PUNCT
aiua-12464	31	141	lahore	lahore	PROPN
aiua-12464	31	142	,	,	PUNCT
aiua-12464	31	143	pakistan	pakistan	PROPN
aiua-12464	31	144	.	.	PUNCT
aiua-12464	32	1	doi	doi	NOUN
aiua-12464	32	2	:	:	PUNCT
aiua-12464	32	3	10.4081	10.4081	NUM
aiua-12464	32	4	/	/	SYM
aiua-12464	32	5	aiua.2024.12464	aiua.2024.12464	PRON
aiua-12464	32	6	summary	summary	NOUN
aiua-12464	32	7	archivio	archivio	NOUN
aiua-12464	32	8	italiano	italiano	NOUN
aiua-12464	32	9	di	di	X
aiua-12464	32	10	urologia	urologia	PROPN
aiua-12464	32	11	e	e	PROPN
aiua-12464	32	12	andrologia	andrologia	NOUN
aiua-12464	32	13	2024	2024	NUM
aiua-12464	32	14	;	;	PUNCT
aiua-12464	32	15	96(3):12464	96(3):12464	NUM
aiua-12464	32	16	k.	k.	PROPN
aiua-12464	32	17	bakhat	bakhat	PROPN
aiua-12464	32	18	,	,	PUNCT
aiua-12464	32	19	i.	i.	PROPN
aiua-12464	32	20	mateen	mateen	PROPN
aiua-12464	32	21	,	,	PUNCT
aiua-12464	32	22	h.	h.	PROPN
aiua-12464	32	23	saif	saif	PROPN
aiua-12464	32	24	,	,	PUNCT
aiua-12464	32	25	et	et	PROPN
aiua-12464	32	26	al	al	PROPN
aiua-12464	32	27	.	.	PROPN
aiua-12464	32	28	2	2	NUM
aiua-12464	32	29	13	13	NUM
aiua-12464	32	30	)	)	PUNCT
aiua-12464	32	31	.	.	PUNCT
aiua-12464	33	1	when	when	SCONJ
aiua-12464	33	2	fluid	fluid	ADJ
aiua-12464	33	3	secretion	secretion	NOUN
aiua-12464	33	4	is	be	AUX
aiua-12464	33	5	disrupted	disrupt	VERB
aiua-12464	33	6	,	,	PUNCT
aiua-12464	33	7	it	it	PRON
aiua-12464	33	8	can	can	AUX
aiua-12464	33	9	lead	lead	VERB
aiua-12464	33	10	to	to	ADP
aiua-12464	33	11	underdevelopment	underdevelopment	NOUN
aiua-12464	33	12	and	and	CCONJ
aiua-12464	33	13	deterioration	deterioration	NOUN
aiua-12464	33	14	of	of	ADP
aiua-12464	33	15	the	the	DET
aiua-12464	33	16	mesonephric	mesonephric	ADJ
aiua-12464	33	17	duct	duct	NOUN
aiua-12464	33	18	in	in	ADP
aiua-12464	33	19	the	the	DET
aiua-12464	33	20	early	early	ADJ
aiua-12464	33	21	stages	stage	NOUN
aiua-12464	33	22	of	of	ADP
aiua-12464	33	23	embryo	embryo	NOUN
aiua-12464	33	24	growth	growth	NOUN
aiua-12464	33	25	(	(	PUNCT
aiua-12464	33	26	14	14	NUM
aiua-12464	33	27	)	)	PUNCT
aiua-12464	33	28	.	.	PUNCT
aiua-12464	34	1	until	until	ADP
aiua-12464	34	2	now	now	ADV
aiua-12464	34	3	,	,	PUNCT
aiua-12464	34	4	over	over	ADP
aiua-12464	34	5	2000	2000	NUM
aiua-12464	34	6	mutations	mutation	NOUN
aiua-12464	34	7	in	in	ADP
aiua-12464	34	8	the	the	DET
aiua-12464	34	9	cftr	cftr	NOUN
aiua-12464	34	10	have	have	AUX
aiua-12464	34	11	been	be	AUX
aiua-12464	34	12	detected	detect	VERB
aiua-12464	34	13	,	,	PUNCT
aiua-12464	34	14	however	however	ADV
aiua-12464	34	15	,	,	PUNCT
aiua-12464	34	16	not	not	PART
aiua-12464	34	17	all	all	PRON
aiua-12464	34	18	of	of	ADP
aiua-12464	34	19	them	they	PRON
aiua-12464	34	20	are	be	AUX
aiua-12464	34	21	pathogenic	pathogenic	ADJ
aiua-12464	34	22	in	in	ADP
aiua-12464	34	23	nature	nature	NOUN
aiua-12464	34	24	.	.	PUNCT
aiua-12464	35	1	a	a	DET
aiua-12464	35	2	relatively	relatively	ADV
aiua-12464	35	3	low	low	ADJ
aiua-12464	35	4	number	number	NOUN
aiua-12464	35	5	of	of	ADP
aiua-12464	35	6	mutations	mutation	NOUN
aiua-12464	35	7	are	be	AUX
aiua-12464	35	8	causing	cause	VERB
aiua-12464	35	9	cftr	cftr	NOUN
aiua-12464	35	10	associated	associate	VERB
aiua-12464	35	11	abnormalities	abnormality	NOUN
aiua-12464	35	12	while	while	SCONJ
aiua-12464	35	13	the	the	DET
aiua-12464	35	14	rest	rest	NOUN
aiua-12464	35	15	are	be	AUX
aiua-12464	35	16	not	not	PART
aiua-12464	35	17	linked	link	VERB
aiua-12464	35	18	with	with	ADP
aiua-12464	35	19	any	any	DET
aiua-12464	35	20	clinical	clinical	ADJ
aiua-12464	35	21	syndromes	syndrome	NOUN
aiua-12464	35	22	.	.	PUNCT
aiua-12464	36	1	around	around	ADP
aiua-12464	36	2	370	370	NUM
aiua-12464	36	3	cftr	cftr	NOUN
aiua-12464	36	4	mutations	mutation	NOUN
aiua-12464	36	5	are	be	AUX
aiua-12464	36	6	listed	list	VERB
aiua-12464	36	7	in	in	ADP
aiua-12464	36	8	the	the	DET
aiua-12464	36	9	clinical	clinical	ADJ
aiua-12464	36	10	and	and	CCONJ
aiua-12464	36	11	functional	functional	ADJ
aiua-12464	36	12	translation	translation	NOUN
aiua-12464	36	13	of	of	ADP
aiua-12464	36	14	the	the	DET
aiua-12464	36	15	cftr	cftr	NOUN
aiua-12464	36	16	project	project	NOUN
aiua-12464	36	17	(	(	PUNCT
aiua-12464	36	18	cftr2	cftr2	PROPN
aiua-12464	36	19	)	)	PUNCT
aiua-12464	36	20	(	(	PUNCT
aiua-12464	36	21	15	15	NUM
aiua-12464	36	22	)	)	PUNCT
aiua-12464	36	23	.	.	PUNCT
aiua-12464	37	1	these	these	DET
aiua-12464	37	2	pathogenic	pathogenic	ADJ
aiua-12464	37	3	variants	variant	NOUN
aiua-12464	37	4	are	be	AUX
aiua-12464	37	5	classified	classify	VERB
aiua-12464	37	6	as	as	ADP
aiua-12464	37	7	mild	mild	ADJ
aiua-12464	37	8	and	and	CCONJ
aiua-12464	37	9	severe	severe	ADJ
aiua-12464	37	10	mutations	mutation	NOUN
aiua-12464	37	11	on	on	ADP
aiua-12464	37	12	the	the	DET
aiua-12464	37	13	basis	basis	NOUN
aiua-12464	37	14	of	of	ADP
aiua-12464	37	15	their	their	PRON
aiua-12464	37	16	phenotypic	phenotypic	ADJ
aiua-12464	37	17	and	and	CCONJ
aiua-12464	37	18	functional	functional	ADJ
aiua-12464	37	19	effect	effect	NOUN
aiua-12464	37	20	.	.	PUNCT
aiua-12464	38	1	two	two	NUM
aiua-12464	38	2	severe	severe	ADJ
aiua-12464	38	3	mutations	mutation	NOUN
aiua-12464	38	4	on	on	ADP
aiua-12464	38	5	both	both	DET
aiua-12464	38	6	alleles	allele	NOUN
aiua-12464	38	7	of	of	ADP
aiua-12464	38	8	the	the	DET
aiua-12464	38	9	cftr	cftr	NOUN
aiua-12464	38	10	causes	cause	VERB
aiua-12464	38	11	cystic	cystic	ADJ
aiua-12464	38	12	fibrosis	fibrosis	NOUN
aiua-12464	38	13	(	(	PUNCT
aiua-12464	38	14	cf	cf	NOUN
aiua-12464	38	15	)	)	PUNCT
aiua-12464	38	16	while	while	SCONJ
aiua-12464	38	17	one	one	NUM
aiua-12464	38	18	severe	severe	ADJ
aiua-12464	38	19	and	and	CCONJ
aiua-12464	38	20	one	one	NUM
aiua-12464	38	21	mild	mild	ADJ
aiua-12464	38	22	or	or	CCONJ
aiua-12464	38	23	both	both	CCONJ
aiua-12464	38	24	mild	mild	ADJ
aiua-12464	38	25	mutations	mutation	NOUN
aiua-12464	38	26	resulted	result	VERB
aiua-12464	38	27	in	in	ADP
aiua-12464	38	28	cbavd	cbavd	NOUN
aiua-12464	38	29	.	.	PUNCT
aiua-12464	39	1	moreover	moreover	ADV
aiua-12464	39	2	,	,	PUNCT
aiua-12464	39	3	all	all	DET
aiua-12464	39	4	cf	cf	NOUN
aiua-12464	39	5	patients	patient	NOUN
aiua-12464	39	6	have	have	VERB
aiua-12464	39	7	cbavd	cbavd	NOUN
aiua-12464	39	8	(	(	PUNCT
aiua-12464	39	9	16	16	NUM
aiua-12464	39	10	)	)	PUNCT
aiua-12464	39	11	.	.	PUNCT
aiua-12464	40	1	cftr	cftr	PROPN
aiua-12464	40	2	mutations	mutation	NOUN
aiua-12464	40	3	have	have	AUX
aiua-12464	40	4	been	be	AUX
aiua-12464	40	5	classified	classify	VERB
aiua-12464	40	6	into	into	ADP
aiua-12464	40	7	six	six	NUM
aiua-12464	40	8	classes	class	NOUN
aiua-12464	40	9	where	where	SCONJ
aiua-12464	40	10	class	class	NOUN
aiua-12464	40	11	i	i	PROPN
aiua-12464	40	12	to	to	ADP
aiua-12464	40	13	iii	iii	NUM
aiua-12464	40	14	variants	variant	NOUN
aiua-12464	40	15	present	present	VERB
aiua-12464	40	16	severe	severe	ADJ
aiua-12464	40	17	manifestations	manifestation	NOUN
aiua-12464	40	18	and	and	CCONJ
aiua-12464	40	19	complete	complete	ADJ
aiua-12464	40	20	loss	loss	NOUN
aiua-12464	40	21	of	of	ADP
aiua-12464	40	22	cftr	cftr	NOUN
aiua-12464	40	23	function	function	NOUN
aiua-12464	40	24	.	.	PUNCT
aiua-12464	41	1	however	however	ADV
aiua-12464	41	2	,	,	PUNCT
aiua-12464	41	3	class	class	NOUN
aiua-12464	41	4	iv	iv	NUM
aiua-12464	41	5	to	to	ADP
aiua-12464	41	6	vi	vi	NOUN
aiua-12464	41	7	variants	variant	NOUN
aiua-12464	41	8	present	present	ADJ
aiua-12464	41	9	mild	mild	ADJ
aiua-12464	41	10	phenotypes	phenotype	NOUN
aiua-12464	41	11	with	with	ADP
aiua-12464	41	12	reduced	reduce	VERB
aiua-12464	41	13	cftr	cftr	NOUN
aiua-12464	41	14	function	function	NOUN
aiua-12464	41	15	(	(	PUNCT
aiua-12464	41	16	2	2	NUM
aiua-12464	41	17	)	)	PUNCT
aiua-12464	41	18	.	.	PUNCT
aiua-12464	42	1	cftr	cftr	PROPN
aiua-12464	42	2	exhibits	exhibit	VERB
aiua-12464	42	3	a	a	DET
aiua-12464	42	4	great	great	ADJ
aiua-12464	42	5	deal	deal	NOUN
aiua-12464	42	6	of	of	ADP
aiua-12464	42	7	heterogeneity	heterogeneity	NOUN
aiua-12464	42	8	due	due	ADP
aiua-12464	42	9	to	to	ADP
aiua-12464	42	10	the	the	DET
aiua-12464	42	11	modifications	modification	NOUN
aiua-12464	42	12	in	in	ADP
aiua-12464	42	13	the	the	DET
aiua-12464	42	14	base	base	NOUN
aiua-12464	42	15	sequence	sequence	NOUN
aiua-12464	42	16	of	of	ADP
aiua-12464	42	17	dna	dna	PROPN
aiua-12464	42	18	which	which	PRON
aiua-12464	42	19	leads	lead	VERB
aiua-12464	42	20	to	to	ADP
aiua-12464	42	21	altered	alter	VERB
aiua-12464	42	22	protein	protein	NOUN
aiua-12464	42	23	expression	expression	NOUN
aiua-12464	42	24	.	.	PUNCT
aiua-12464	43	1	diverse	diverse	ADJ
aiua-12464	43	2	migratory	migratory	NOUN
aiua-12464	43	3	patterns	pattern	NOUN
aiua-12464	43	4	and	and	CCONJ
aiua-12464	43	5	settlement	settlement	NOUN
aiua-12464	43	6	have	have	AUX
aiua-12464	43	7	led	lead	VERB
aiua-12464	43	8	to	to	ADP
aiua-12464	43	9	heterogeneity	heterogeneity	NOUN
aiua-12464	43	10	in	in	ADP
aiua-12464	43	11	mutations	mutation	NOUN
aiua-12464	43	12	worldwide	worldwide	ADV
aiua-12464	43	13	.	.	PUNCT
aiua-12464	44	1	the	the	DET
aiua-12464	44	2	relationship	relationship	NOUN
aiua-12464	44	3	between	between	ADP
aiua-12464	44	4	cbavd	cbavd	NOUN
aiua-12464	44	5	and	and	CCONJ
aiua-12464	44	6	cftr	cftr	NOUN
aiua-12464	44	7	is	be	AUX
aiua-12464	44	8	well	well	ADV
aiua-12464	44	9	established	establish	VERB
aiua-12464	44	10	but	but	CCONJ
aiua-12464	44	11	it	it	PRON
aiua-12464	44	12	is	be	AUX
aiua-12464	44	13	least	least	ADV
aiua-12464	44	14	studied	study	VERB
aiua-12464	44	15	and	and	CCONJ
aiua-12464	44	16	documented	document	VERB
aiua-12464	44	17	in	in	ADP
aiua-12464	44	18	the	the	DET
aiua-12464	44	19	asian	asian	ADJ
aiua-12464	44	20	population	population	NOUN
aiua-12464	44	21	.	.	PUNCT
aiua-12464	45	1	that	that	PRON
aiua-12464	45	2	was	be	AUX
aiua-12464	45	3	the	the	DET
aiua-12464	45	4	reason	reason	NOUN
aiua-12464	45	5	of	of	ADP
aiua-12464	45	6	our	our	PRON
aiua-12464	45	7	study	study	NOUN
aiua-12464	45	8	aiming	aim	VERB
aiua-12464	45	9	to	to	ADP
aiua-12464	45	10	the	the	DET
aiua-12464	45	11	analysis	analysis	NOUN
aiua-12464	45	12	of	of	ADP
aiua-12464	45	13	the	the	DET
aiua-12464	45	14	genetic	genetic	ADJ
aiua-12464	45	15	integrity	integrity	NOUN
aiua-12464	45	16	of	of	ADP
aiua-12464	45	17	promoter	promoter	NOUN
aiua-12464	45	18	region	region	NOUN
aiua-12464	45	19	and	and	CCONJ
aiua-12464	45	20	exon	exon	NOUN
aiua-12464	45	21	10	10	NUM
aiua-12464	45	22	of	of	ADP
aiua-12464	45	23	cftr	cftr	NOUN
aiua-12464	45	24	to	to	PART
aiua-12464	45	25	identify	identify	VERB
aiua-12464	45	26	mutations	mutation	NOUN
aiua-12464	45	27	in	in	ADP
aiua-12464	45	28	individuals	individual	NOUN
aiua-12464	45	29	with	with	ADP
aiua-12464	45	30	cbavd	cbavd	NOUN
aiua-12464	45	31	in	in	ADP
aiua-12464	45	32	a	a	DET
aiua-12464	45	33	pakistani	pakistani	ADJ
aiua-12464	45	34	population	population	NOUN
aiua-12464	45	35	.	.	PUNCT
aiua-12464	46	1	materials	material	NOUN
aiua-12464	46	2	and	and	CCONJ
aiua-12464	46	3	methods	method	NOUN
aiua-12464	46	4	ethics	ethic	NOUN
aiua-12464	46	5	statement	statement	NOUN
aiua-12464	46	6	this	this	DET
aiua-12464	46	7	study	study	NOUN
aiua-12464	46	8	was	be	AUX
aiua-12464	46	9	approved	approve	VERB
aiua-12464	46	10	by	by	ADP
aiua-12464	46	11	the	the	DET
aiua-12464	46	12	ethical	ethical	PROPN
aiua-12464	46	13	review	review	PROPN
aiua-12464	46	14	committee	committee	PROPN
aiua-12464	46	15	of	of	ADP
aiua-12464	46	16	forman	forman	PROPN
aiua-12464	46	17	christian	christian	PROPN
aiua-12464	46	18	college	college	PROPN
aiua-12464	46	19	(	(	PUNCT
aiua-12464	46	20	a	a	DET
aiua-12464	46	21	chartered	chartered	ADJ
aiua-12464	46	22	university	university	NOUN
aiua-12464	46	23	)	)	PUNCT
aiua-12464	46	24	lahore	lahore	PROPN
aiua-12464	46	25	,	,	PUNCT
aiua-12464	46	26	pakistan	pakistan	PROPN
aiua-12464	46	27	(	(	PUNCT
aiua-12464	46	28	erc-81	erc-81	NOUN
aiua-12464	46	29	-	-	PUNCT
aiua-12464	46	30	2017	2017	NUM
aiua-12464	46	31	dated	date	VERB
aiua-12464	46	32	:	:	PUNCT
aiua-12464	46	33	11	11	NUM
aiua-12464	46	34	,	,	PUNCT
aiua-12464	46	35	september	september	PROPN
aiua-12464	46	36	2017	2017	NUM
aiua-12464	46	37	)	)	PUNCT
aiua-12464	46	38	.	.	PUNCT
aiua-12464	47	1	all	all	DET
aiua-12464	47	2	the	the	DET
aiua-12464	47	3	experiments	experiment	NOUN
aiua-12464	47	4	were	be	AUX
aiua-12464	47	5	performed	perform	VERB
aiua-12464	47	6	according	accord	VERB
aiua-12464	47	7	to	to	ADP
aiua-12464	47	8	the	the	DET
aiua-12464	47	9	approved	approve	VERB
aiua-12464	47	10	guidelines	guideline	NOUN
aiua-12464	47	11	.	.	PUNCT
aiua-12464	48	1	blood	blood	NOUN
aiua-12464	48	2	sampling	sampling	NOUN
aiua-12464	48	3	and	and	CCONJ
aiua-12464	48	4	dna	dna	NOUN
aiua-12464	48	5	extraction	extraction	NOUN
aiua-12464	48	6	the	the	DET
aiua-12464	48	7	term	term	NOUN
aiua-12464	48	8	subjects	subject	NOUN
aiua-12464	48	9	has	have	AUX
aiua-12464	48	10	been	be	AUX
aiua-12464	48	11	used	use	VERB
aiua-12464	48	12	for	for	ADP
aiua-12464	48	13	both	both	DET
aiua-12464	48	14	patients	patient	NOUN
aiua-12464	48	15	and	and	CCONJ
aiua-12464	48	16	healthy	healthy	ADJ
aiua-12464	48	17	controls	control	NOUN
aiua-12464	48	18	taking	take	VERB
aiua-12464	48	19	part	part	NOUN
aiua-12464	48	20	in	in	ADP
aiua-12464	48	21	our	our	PRON
aiua-12464	48	22	study	study	NOUN
aiua-12464	48	23	.	.	PUNCT
aiua-12464	49	1	archived	archive	VERB
aiua-12464	49	2	blood	blood	NOUN
aiua-12464	49	3	samples	sample	NOUN
aiua-12464	49	4	from	from	ADP
aiua-12464	49	5	31	31	NUM
aiua-12464	49	6	patients	patient	NOUN
aiua-12464	49	7	with	with	ADP
aiua-12464	49	8	cbavd	cbavd	NOUN
aiua-12464	49	9	and	and	CCONJ
aiua-12464	49	10	azoospermia	azoospermia	NOUN
aiua-12464	49	11	together	together	ADV
aiua-12464	49	12	with	with	ADP
aiua-12464	49	13	those	those	PRON
aiua-12464	49	14	of	of	ADP
aiua-12464	49	15	10	10	NUM
aiua-12464	49	16	healthy	healthy	ADJ
aiua-12464	49	17	controls	control	NOUN
aiua-12464	49	18	were	be	AUX
aiua-12464	49	19	gifted	gift	VERB
aiua-12464	49	20	by	by	ADP
aiua-12464	49	21	fatima	fatima	PROPN
aiua-12464	49	22	memorial	memorial	PROPN
aiua-12464	49	23	hospital	hospital	NOUN
aiua-12464	49	24	(	(	PUNCT
aiua-12464	49	25	fmh	fmh	PROPN
aiua-12464	49	26	)	)	PUNCT
aiua-12464	49	27	,	,	PUNCT
aiua-12464	49	28	lahore	lahore	PROPN
aiua-12464	49	29	pakistan	pakistan	PROPN
aiua-12464	49	30	.	.	PUNCT
aiua-12464	50	1	blood	blood	NOUN
aiua-12464	50	2	samples	sample	NOUN
aiua-12464	50	3	were	be	AUX
aiua-12464	50	4	collected	collect	VERB
aiua-12464	50	5	for	for	ADP
aiua-12464	50	6	research	research	NOUN
aiua-12464	50	7	after	after	ADP
aiua-12464	50	8	the	the	DET
aiua-12464	50	9	approval	approval	NOUN
aiua-12464	50	10	of	of	ADP
aiua-12464	50	11	the	the	DET
aiua-12464	50	12	institutional	institutional	ADJ
aiua-12464	50	13	review	review	PROPN
aiua-12464	50	14	board	board	NOUN
aiua-12464	50	15	of	of	ADP
aiua-12464	50	16	fatima	fatima	PROPN
aiua-12464	50	17	memorial	memorial	ADJ
aiua-12464	50	18	hospital	hospital	NOUN
aiua-12464	50	19	,	,	PUNCT
aiua-12464	50	20	lahore	lahore	PROPN
aiua-12464	50	21	pakistan	pakistan	PROPN
aiua-12464	50	22	(	(	PUNCT
aiua-12464	50	23	fmh-102018	fmh-102018	X
aiua-12464	50	24	-	-	PUNCT
aiua-12464	50	25	irb-520	irb-520	PROPN
aiua-12464	50	26	-	-	PUNCT
aiua-12464	50	27	f	f	PROPN
aiua-12464	50	28	dated	date	VERB
aiua-12464	50	29	:	:	PUNCT
aiua-12464	50	30	23	23	NUM
aiua-12464	50	31	,	,	PUNCT
aiua-12464	50	32	october	october	PROPN
aiua-12464	50	33	2023	2023	NUM
aiua-12464	50	34	)	)	PUNCT
aiua-12464	50	35	and	and	CCONJ
aiua-12464	50	36	archived	archive	VERB
aiua-12464	50	37	for	for	ADP
aiua-12464	50	38	further	further	ADJ
aiua-12464	50	39	research	research	NOUN
aiua-12464	50	40	.	.	PUNCT
aiua-12464	51	1	extracted	extract	VERB
aiua-12464	51	2	dnas	dna	NOUN
aiua-12464	51	3	from	from	ADP
aiua-12464	51	4	17	17	NUM
aiua-12464	51	5	patients	patient	NOUN
aiua-12464	51	6	and	and	CCONJ
aiua-12464	51	7	10	10	NUM
aiua-12464	51	8	healthy	healthy	ADJ
aiua-12464	51	9	controls	control	NOUN
aiua-12464	51	10	were	be	AUX
aiua-12464	51	11	selected	select	VERB
aiua-12464	51	12	for	for	ADP
aiua-12464	51	13	further	further	ADJ
aiua-12464	51	14	processing	processing	NOUN
aiua-12464	51	15	.	.	PUNCT
aiua-12464	52	1	the	the	DET
aiua-12464	52	2	authors	author	NOUN
aiua-12464	52	3	had	have	VERB
aiua-12464	52	4	no	no	DET
aiua-12464	52	5	access	access	NOUN
aiua-12464	52	6	to	to	ADP
aiua-12464	52	7	information	information	NOUN
aiua-12464	52	8	that	that	PRON
aiua-12464	52	9	could	could	AUX
aiua-12464	52	10	identify	identify	VERB
aiua-12464	52	11	individual	individual	ADJ
aiua-12464	52	12	participants	participant	NOUN
aiua-12464	52	13	during	during	ADP
aiua-12464	52	14	or	or	CCONJ
aiua-12464	52	15	after	after	ADP
aiua-12464	52	16	data	data	NOUN
aiua-12464	52	17	collection	collection	NOUN
aiua-12464	52	18	.	.	PUNCT
aiua-12464	53	1	all	all	DET
aiua-12464	53	2	the	the	DET
aiua-12464	53	3	patients	patient	NOUN
aiua-12464	53	4	were	be	AUX
aiua-12464	53	5	examined	examine	VERB
aiua-12464	53	6	by	by	ADP
aiua-12464	53	7	the	the	DET
aiua-12464	53	8	same	same	ADJ
aiua-12464	53	9	physician	physician	NOUN
aiua-12464	53	10	.	.	PUNCT
aiua-12464	54	1	cbavd	cbavd	PROPN
aiua-12464	54	2	was	be	AUX
aiua-12464	54	3	primarily	primarily	ADV
aiua-12464	54	4	diagnosed	diagnose	VERB
aiua-12464	54	5	by	by	ADP
aiua-12464	54	6	impalpable	impalpable	ADJ
aiua-12464	54	7	scrotal	scrotal	ADJ
aiua-12464	54	8	vas	vas	X
aiua-12464	54	9	on	on	ADP
aiua-12464	54	10	physical	physical	ADJ
aiua-12464	54	11	examination	examination	NOUN
aiua-12464	54	12	,	,	PUNCT
aiua-12464	54	13	followed	follow	VERB
aiua-12464	54	14	by	by	ADP
aiua-12464	54	15	ultrasonography	ultrasonography	NOUN
aiua-12464	54	16	.	.	PUNCT
aiua-12464	55	1	eventually	eventually	ADV
aiua-12464	55	2	,	,	PUNCT
aiua-12464	55	3	diagnosis	diagnosis	NOUN
aiua-12464	55	4	was	be	AUX
aiua-12464	55	5	confirmed	confirm	VERB
aiua-12464	55	6	by	by	ADP
aiua-12464	55	7	cytobiochemical	cytobiochemical	ADJ
aiua-12464	55	8	characteristics	characteristic	NOUN
aiua-12464	55	9	:	:	PUNCT
aiua-12464	55	10	decreased	decrease	VERB
aiua-12464	55	11	concentration	concentration	NOUN
aiua-12464	55	12	of	of	ADP
aiua-12464	55	13	fructose	fructose	NOUN
aiua-12464	55	14	and	and	CCONJ
aiua-12464	55	15	carnitine	carnitine	NOUN
aiua-12464	55	16	,	,	PUNCT
aiua-12464	55	17	azoospermia	azoospermia	NOUN
aiua-12464	55	18	with	with	ADP
aiua-12464	55	19	low	low	ADJ
aiua-12464	55	20	ph	ph	X
aiua-12464	55	21	<	<	X
aiua-12464	55	22	7	7	NUM
aiua-12464	55	23	and	and	CCONJ
aiua-12464	55	24	normal	normal	ADJ
aiua-12464	55	25	hormone	hormone	NOUN
aiua-12464	55	26	concentration	concentration	NOUN
aiua-12464	55	27	(	(	PUNCT
aiua-12464	55	28	9	9	NUM
aiua-12464	55	29	)	)	PUNCT
aiua-12464	55	30	.	.	PUNCT
aiua-12464	56	1	all	all	DET
aiua-12464	56	2	participants	participant	NOUN
aiua-12464	56	3	had	have	VERB
aiua-12464	56	4	no	no	DET
aiua-12464	56	5	classical	classical	ADJ
aiua-12464	56	6	symptoms	symptom	NOUN
aiua-12464	56	7	of	of	ADP
aiua-12464	56	8	cf	cf	NOUN
aiua-12464	56	9	.	.	PUNCT
aiua-12464	57	1	written	write	VERB
aiua-12464	57	2	informed	informed	ADJ
aiua-12464	57	3	consent	consent	NOUN
aiua-12464	57	4	was	be	AUX
aiua-12464	57	5	taken	take	VERB
aiua-12464	57	6	from	from	ADP
aiua-12464	57	7	the	the	DET
aiua-12464	57	8	participants	participant	NOUN
aiua-12464	57	9	for	for	ADP
aiua-12464	57	10	the	the	DET
aiua-12464	57	11	study	study	NOUN
aiua-12464	57	12	.	.	PUNCT
aiua-12464	58	1	genomic	genomic	PROPN
aiua-12464	58	2	dna	dna	PROPN
aiua-12464	58	3	was	be	AUX
aiua-12464	58	4	isolated	isolate	VERB
aiua-12464	58	5	from	from	ADP
aiua-12464	58	6	whole	whole	ADJ
aiua-12464	58	7	blood	blood	NOUN
aiua-12464	58	8	cells	cell	NOUN
aiua-12464	58	9	by	by	ADP
aiua-12464	58	10	using	use	VERB
aiua-12464	58	11	standard	standard	ADJ
aiua-12464	58	12	phenol	phenol	ADJ
aiua-12464	58	13	chloroform	chloroform	NOUN
aiua-12464	58	14	method	method	NOUN
aiua-12464	58	15	(	(	PUNCT
aiua-12464	58	16	17	17	NUM
aiua-12464	58	17	)	)	PUNCT
aiua-12464	58	18	.	.	PUNCT
aiua-12464	59	1	pcr	pcr	ADJ
aiua-12464	59	2	conditions	condition	NOUN
aiua-12464	59	3	and	and	CCONJ
aiua-12464	59	4	identification	identification	NOUN
aiua-12464	59	5	of	of	ADP
aiua-12464	59	6	variants	variant	NOUN
aiua-12464	59	7	for	for	ADP
aiua-12464	59	8	screening	screen	VERB
aiua-12464	59	9	purposes	purpose	NOUN
aiua-12464	59	10	,	,	PUNCT
aiua-12464	59	11	the	the	DET
aiua-12464	59	12	promoter	promoter	NOUN
aiua-12464	59	13	region	region	NOUN
aiua-12464	59	14	(	(	PUNCT
aiua-12464	59	15	pr	pr	NOUN
aiua-12464	59	16	-	-	PUNCT
aiua-12464	59	17	cftr	cftr	NOUN
aiua-12464	59	18	)	)	PUNCT
aiua-12464	59	19	and	and	CCONJ
aiua-12464	59	20	exon	exon	NOUN
aiua-12464	59	21	10	10	NUM
aiua-12464	59	22	(	(	PUNCT
aiua-12464	59	23	ex10	ex10	PROPN
aiua-12464	59	24	-	-	PUNCT
aiua-12464	59	25	cftr	cftr	NOUN
aiua-12464	59	26	)	)	PUNCT
aiua-12464	59	27	were	be	AUX
aiua-12464	59	28	amplified	amplify	VERB
aiua-12464	59	29	by	by	ADP
aiua-12464	59	30	polymerase	polymerase	NOUN
aiua-12464	59	31	chain	chain	NOUN
aiua-12464	59	32	reaction	reaction	NOUN
aiua-12464	59	33	(	(	PUNCT
aiua-12464	59	34	pcr	pcr	NOUN
aiua-12464	59	35	)	)	PUNCT
aiua-12464	59	36	using	use	VERB
aiua-12464	59	37	specific	specific	ADJ
aiua-12464	59	38	sets	set	NOUN
aiua-12464	59	39	of	of	ADP
aiua-12464	59	40	primers	primer	NOUN
aiua-12464	59	41	(	(	PUNCT
aiua-12464	59	42	table	table	NOUN
aiua-12464	59	43	1	1	NUM
aiua-12464	59	44	supplementary	supplementary	ADJ
aiua-12464	59	45	materials	material	NOUN
aiua-12464	59	46	)	)	PUNCT
aiua-12464	59	47	(	(	PUNCT
aiua-12464	59	48	figure	figure	NOUN
aiua-12464	59	49	1	1	NUM
aiua-12464	59	50	)	)	PUNCT
aiua-12464	59	51	.	.	PUNCT
aiua-12464	60	1	pcr	pcr	ADJ
aiua-12464	60	2	conditions	condition	NOUN
aiua-12464	60	3	for	for	ADP
aiua-12464	60	4	the	the	DET
aiua-12464	60	5	amplification	amplification	NOUN
aiua-12464	60	6	of	of	ADP
aiua-12464	60	7	selected	select	VERB
aiua-12464	60	8	regions	region	NOUN
aiua-12464	60	9	were	be	AUX
aiua-12464	60	10	:	:	PUNCT
aiua-12464	60	11	initial	initial	ADJ
aiua-12464	60	12	denaturation	denaturation	NOUN
aiua-12464	60	13	at	at	ADP
aiua-12464	60	14	94	94	NUM
aiua-12464	60	15	°	°	ADP
aiua-12464	60	16	c	c	NOUN
aiua-12464	60	17	for	for	ADP
aiua-12464	60	18	5	5	NUM
aiua-12464	60	19	minutes	minute	NOUN
aiua-12464	60	20	followed	follow	VERB
aiua-12464	60	21	by	by	ADP
aiua-12464	60	22	35	35	NUM
aiua-12464	60	23	cycles	cycle	NOUN
aiua-12464	60	24	of	of	ADP
aiua-12464	60	25	1	1	NUM
aiua-12464	60	26	min	min	NOUN
aiua-12464	60	27	at	at	ADP
aiua-12464	60	28	94	94	NUM
aiua-12464	60	29	°	°	NOUN
aiua-12464	60	30	c	c	NOUN
aiua-12464	60	31	,	,	PUNCT
aiua-12464	60	32	annealing	anneal	VERB
aiua-12464	60	33	for	for	ADP
aiua-12464	60	34	48s	48	NOUN
aiua-12464	60	35	at	at	ADP
aiua-12464	60	36	61.6	61.6	NUM
aiua-12464	60	37	°	°	NOUN
aiua-12464	60	38	c	c	NOUN
aiua-12464	60	39	for	for	ADP
aiua-12464	60	40	ex10	ex10	PROPN
aiua-12464	60	41	-	-	PUNCT
aiua-12464	60	42	cftr	cftr	NOUN
aiua-12464	60	43	and	and	CCONJ
aiua-12464	60	44	at	at	ADP
aiua-12464	60	45	58.8	58.8	NUM
aiua-12464	60	46	°	°	ADP
aiua-12464	60	47	c	c	NOUN
aiua-12464	60	48	for	for	ADP
aiua-12464	60	49	pr	pr	NOUN
aiua-12464	60	50	-	-	PUNCT
aiua-12464	60	51	cftr	cftr	NOUN
aiua-12464	60	52	,	,	PUNCT
aiua-12464	60	53	elongation	elongation	NOUN
aiua-12464	60	54	carried	carry	VERB
aiua-12464	60	55	out	out	ADP
aiua-12464	60	56	at	at	ADP
aiua-12464	60	57	72	72	NUM
aiua-12464	60	58	°	°	ADP
aiua-12464	60	59	c	c	NOUN
aiua-12464	60	60	for	for	ADP
aiua-12464	60	61	1	1	NUM
aiua-12464	60	62	minute	minute	NOUN
aiua-12464	60	63	and	and	CCONJ
aiua-12464	60	64	final	final	ADJ
aiua-12464	60	65	elongation	elongation	NOUN
aiua-12464	60	66	at	at	ADP
aiua-12464	60	67	72	72	NUM
aiua-12464	60	68	°	°	ADP
aiua-12464	60	69	c	c	NOUN
aiua-12464	60	70	for	for	ADP
aiua-12464	60	71	5	5	NUM
aiua-12464	60	72	min	min	NOUN
aiua-12464	60	73	.	.	PROPN
aiua-12464	60	74	pcr	pcr	ADJ
aiua-12464	60	75	products	product	NOUN
aiua-12464	60	76	of	of	ADP
aiua-12464	60	77	the	the	DET
aiua-12464	60	78	17	17	NUM
aiua-12464	60	79	patients	patient	NOUN
aiua-12464	60	80	and	and	CCONJ
aiua-12464	60	81	10	10	NUM
aiua-12464	60	82	control	control	NOUN
aiua-12464	60	83	samples	sample	NOUN
aiua-12464	60	84	were	be	AUX
aiua-12464	60	85	purified	purify	VERB
aiua-12464	60	86	using	use	VERB
aiua-12464	60	87	minelute	minelute	ADJ
aiua-12464	60	88	pcr	pcr	PROPN
aiua-12464	60	89	purification	purification	NOUN
aiua-12464	60	90	kit	kit	NOUN
aiua-12464	60	91	,	,	PUNCT
aiua-12464	60	92	(	(	PUNCT
aiua-12464	60	93	qiagen	qiagen	PROPN
aiua-12464	60	94	,	,	PUNCT
aiua-12464	60	95	valencia	valencia	PROPN
aiua-12464	60	96	,	,	PUNCT
aiua-12464	60	97	ca	ca	NOUN
aiua-12464	60	98	)	)	PUNCT
aiua-12464	60	99	and	and	CCONJ
aiua-12464	60	100	then	then	ADV
aiua-12464	60	101	sequenced	sequence	VERB
aiua-12464	60	102	by	by	ADP
aiua-12464	60	103	macrogen	macrogen	PROPN
aiua-12464	60	104	(	(	PUNCT
aiua-12464	60	105	inc	inc	PROPN
aiua-12464	60	106	.	.	PROPN
aiua-12464	60	107	company	company	PROPN
aiua-12464	60	108	,	,	PUNCT
aiua-12464	60	109	south	south	PROPN
aiua-12464	60	110	korea	korea	PROPN
aiua-12464	60	111	)	)	PUNCT
aiua-12464	60	112	.	.	PUNCT
aiua-12464	61	1	dna	dna	PROPN
aiua-12464	61	2	sequencing	sequencing	NOUN
aiua-12464	61	3	was	be	AUX
aiua-12464	61	4	performed	perform	VERB
aiua-12464	61	5	using	use	VERB
aiua-12464	61	6	forward	forward	ADV
aiua-12464	61	7	primers	primer	NOUN
aiua-12464	61	8	of	of	ADP
aiua-12464	61	9	both	both	PRON
aiua-12464	61	10	exon	exon	ADJ
aiua-12464	61	11	10	10	NUM
aiua-12464	61	12	and	and	CCONJ
aiua-12464	61	13	promoter	promoter	NOUN
aiua-12464	61	14	region	region	NOUN
aiua-12464	61	15	labeled	label	VERB
aiua-12464	61	16	as	as	ADP
aiua-12464	61	17	ex10cftr	ex10cftr	NOUN
aiua-12464	61	18	-	-	PUNCT
aiua-12464	61	19	fwd	fwd	NOUN
aiua-12464	61	20	and	and	CCONJ
aiua-12464	61	21	pr	pr	NOUN
aiua-12464	61	22	-	-	PUNCT
aiua-12464	61	23	cftr	cftr	NOUN
aiua-12464	61	24	-	-	PUNCT
aiua-12464	61	25	fwd	fwd	NOUN
aiua-12464	61	26	respectively	respectively	ADV
aiua-12464	61	27	;	;	PUNCT
aiua-12464	61	28	afterwards	afterwards	ADV
aiua-12464	61	29	,	,	PUNCT
aiua-12464	61	30	sequencing	sequencing	NOUN
aiua-12464	61	31	results	result	NOUN
aiua-12464	61	32	were	be	AUX
aiua-12464	61	33	analyzed	analyze	VERB
aiua-12464	61	34	and	and	CCONJ
aiua-12464	61	35	confirmed	confirm	VERB
aiua-12464	61	36	using	use	VERB
aiua-12464	61	37	serial	serial	ADJ
aiua-12464	61	38	cloner	cloner	NOUN
aiua-12464	61	39	,	,	PUNCT
aiua-12464	61	40	snapgene	snapgene	NOUN
aiua-12464	61	41	,	,	PUNCT
aiua-12464	61	42	bioedit	bioedit	NOUN
aiua-12464	61	43	and	and	CCONJ
aiua-12464	61	44	finchtv	finchtv	ADJ
aiua-12464	61	45	.	.	PUNCT
aiua-12464	62	1	figure	figure	NOUN
aiua-12464	62	2	1	1	NUM
aiua-12464	62	3	.	.	PUNCT
aiua-12464	62	4	archivio	archivio	NOUN
aiua-12464	62	5	italiano	italiano	X
aiua-12464	62	6	di	di	X
aiua-12464	62	7	urologia	urologia	PROPN
aiua-12464	62	8	e	e	PROPN
aiua-12464	62	9	andrologia	andrologia	NOUN
aiua-12464	62	10	2024	2024	NUM
aiua-12464	62	11	;	;	PUNCT
aiua-12464	62	12	96(3):12464	96(3):12464	NUM
aiua-12464	62	13	3	3	NUM
aiua-12464	62	14	cftr	cftr	NOUN
aiua-12464	62	15	exon	exon	PROPN
aiua-12464	62	16	10	10	NUM
aiua-12464	62	17	mutations	mutation	NOUN
aiua-12464	62	18	and	and	CCONJ
aiua-12464	62	19	congenital	congenital	ADJ
aiua-12464	62	20	bilateral	bilateral	ADJ
aiua-12464	62	21	absence	absence	NOUN
aiua-12464	62	22	of	of	ADP
aiua-12464	62	23	vas	vas	X
aiua-12464	62	24	deferens	deferens	PROPN
aiua-12464	62	25	for	for	ADP
aiua-12464	62	26	mutation	mutation	NOUN
aiua-12464	62	27	confirmation	confirmation	NOUN
aiua-12464	62	28	,	,	PUNCT
aiua-12464	62	29	sequencing	sequence	VERB
aiua-12464	62	30	data	datum	NOUN
aiua-12464	62	31	with	with	ADP
aiua-12464	62	32	quality	quality	NOUN
aiua-12464	62	33	chromatogram	chromatogram	NOUN
aiua-12464	62	34	peaks	peak	NOUN
aiua-12464	62	35	were	be	AUX
aiua-12464	62	36	selected	select	VERB
aiua-12464	62	37	(	(	PUNCT
aiua-12464	62	38	figures	figure	NOUN
aiua-12464	62	39	2	2	NUM
aiua-12464	62	40	,	,	PUNCT
aiua-12464	62	41	3	3	NUM
aiua-12464	62	42	)	)	PUNCT
aiua-12464	62	43	.	.	PUNCT
aiua-12464	63	1	in	in	ADP
aiua-12464	63	2	-	-	PUNCT
aiua-12464	63	3	silico	silico	NOUN
aiua-12464	63	4	analysis	analysis	NOUN
aiua-12464	63	5	of	of	ADP
aiua-12464	63	6	cftr	cftr	NOUN
aiua-12464	63	7	protein	protein	NOUN
aiua-12464	63	8	with	with	ADP
aiua-12464	63	9	respect	respect	NOUN
aiua-12464	63	10	to	to	PART
aiua-12464	63	11	missense	missense	VERB
aiua-12464	63	12	mutations	mutation	NOUN
aiua-12464	63	13	(	(	PUNCT
aiua-12464	63	14	v456a	v456a	PROPN
aiua-12464	63	15	and	and	CCONJ
aiua-12464	63	16	k464e	k464e	PROPN
aiua-12464	63	17	)	)	PUNCT
aiua-12464	64	1	analysis	analysis	NOUN
aiua-12464	64	2	of	of	ADP
aiua-12464	64	3	conserved	conserve	VERB
aiua-12464	64	4	amino	amino	NOUN
aiua-12464	64	5	acid	acid	NOUN
aiua-12464	64	6	residues	residue	NOUN
aiua-12464	64	7	the	the	DET
aiua-12464	64	8	evolutionary	evolutionary	ADJ
aiua-12464	64	9	conserved	conserve	VERB
aiua-12464	64	10	amino	amino	NOUN
aiua-12464	64	11	acid	acid	NOUN
aiua-12464	64	12	sequences	sequence	NOUN
aiua-12464	64	13	of	of	ADP
aiua-12464	64	14	cftr	cftr	NOUN
aiua-12464	64	15	protein	protein	NOUN
aiua-12464	64	16	were	be	AUX
aiua-12464	64	17	checked	check	VERB
aiua-12464	64	18	by	by	ADP
aiua-12464	64	19	consurf	consurf	NOUN
aiua-12464	64	20	.	.	PUNCT
aiua-12464	65	1	by	by	ADP
aiua-12464	65	2	using	use	VERB
aiua-12464	65	3	multiple	multiple	ADJ
aiua-12464	65	4	sequence	sequence	NOUN
aiua-12464	65	5	alignment	alignment	NOUN
aiua-12464	65	6	(	(	PUNCT
aiua-12464	65	7	msa	msa	PROPN
aiua-12464	65	8	)	)	PUNCT
aiua-12464	65	9	of	of	ADP
aiua-12464	65	10	homologous	homologous	ADJ
aiua-12464	65	11	protein	protein	NOUN
aiua-12464	65	12	sequences	sequence	NOUN
aiua-12464	65	13	as	as	ADP
aiua-12464	65	14	primary	primary	ADJ
aiua-12464	65	15	input	input	NOUN
aiua-12464	65	16	,	,	PUNCT
aiua-12464	65	17	consurf	consurf	NOUN
aiua-12464	65	18	calculates	calculate	VERB
aiua-12464	65	19	a	a	DET
aiua-12464	65	20	conservation	conservation	NOUN
aiua-12464	65	21	score	score	NOUN
aiua-12464	65	22	(	(	PUNCT
aiua-12464	65	23	1	1	NUM
aiua-12464	65	24	-	-	SYM
aiua-12464	65	25	9	9	NUM
aiua-12464	65	26	)	)	PUNCT
aiua-12464	65	27	for	for	ADP
aiua-12464	65	28	each	each	DET
aiua-12464	65	29	amino	amino	NOUN
aiua-12464	65	30	acid	acid	NOUN
aiua-12464	65	31	position	position	NOUN
aiua-12464	65	32	in	in	ADP
aiua-12464	65	33	the	the	DET
aiua-12464	65	34	protein	protein	NOUN
aiua-12464	65	35	sequence	sequence	NOUN
aiua-12464	65	36	where	where	SCONJ
aiua-12464	65	37	7	7	NUM
aiua-12464	65	38	-	-	SYM
aiua-12464	65	39	9	9	NUM
aiua-12464	65	40	score	score	NOUN
aiua-12464	65	41	indicates	indicate	VERB
aiua-12464	65	42	conserved	conserve	VERB
aiua-12464	65	43	amino	amino	NOUN
aiua-12464	65	44	acid	acid	NOUN
aiua-12464	65	45	(	(	PUNCT
aiua-12464	65	46	18	18	NUM
aiua-12464	65	47	)	)	PUNCT
aiua-12464	65	48	.	.	PUNCT
aiua-12464	66	1	probing	probe	VERB
aiua-12464	66	2	of	of	ADP
aiua-12464	66	3	structural	structural	ADJ
aiua-12464	66	4	and	and	CCONJ
aiua-12464	66	5	functional	functional	ADJ
aiua-12464	66	6	effects	effect	NOUN
aiua-12464	66	7	of	of	ADP
aiua-12464	66	8	mutations	mutation	NOUN
aiua-12464	66	9	hope	hope	VERB
aiua-12464	66	10	(	(	PUNCT
aiua-12464	66	11	have	have	AUX
aiua-12464	66	12	(	(	PUNCT
aiua-12464	66	13	y	y	X
aiua-12464	66	14	)	)	PUNCT
aiua-12464	66	15	our	our	PRON
aiua-12464	66	16	protein	protein	NOUN
aiua-12464	66	17	explained	explain	VERB
aiua-12464	66	18	)	)	PUNCT
aiua-12464	66	19	(	(	PUNCT
aiua-12464	66	20	https://www3.cmbi	https://www3.cmbi	INTJ
aiua-12464	66	21	.	.	PUNCT
aiua-12464	67	1	umcn.nl/hope/	umcn.nl/hope/	NOUN
aiua-12464	67	2	)	)	PUNCT
aiua-12464	67	3	was	be	AUX
aiua-12464	67	4	used	use	VERB
aiua-12464	67	5	for	for	ADP
aiua-12464	67	6	analysis	analysis	NOUN
aiua-12464	67	7	of	of	ADP
aiua-12464	67	8	the	the	DET
aiua-12464	67	9	potential	potential	ADJ
aiua-12464	67	10	impact	impact	NOUN
aiua-12464	67	11	of	of	ADP
aiua-12464	67	12	amino	amino	NOUN
aiua-12464	67	13	acid	acid	NOUN
aiua-12464	67	14	substitutions	substitution	NOUN
aiua-12464	67	15	on	on	ADP
aiua-12464	67	16	protein	protein	NOUN
aiua-12464	67	17	function	function	NOUN
aiua-12464	67	18	and	and	CCONJ
aiua-12464	67	19	stability	stability	NOUN
aiua-12464	67	20	.	.	PUNCT
aiua-12464	68	1	amino	amino	NOUN
aiua-12464	68	2	acid	acid	NOUN
aiua-12464	68	3	sequence	sequence	NOUN
aiua-12464	68	4	of	of	ADP
aiua-12464	68	5	the	the	DET
aiua-12464	68	6	protein	protein	NOUN
aiua-12464	68	7	along	along	ADP
aiua-12464	68	8	with	with	ADP
aiua-12464	68	9	information	information	NOUN
aiua-12464	68	10	about	about	ADP
aiua-12464	68	11	the	the	DET
aiua-12464	68	12	mutation	mutation	NOUN
aiua-12464	68	13	was	be	AUX
aiua-12464	68	14	provided	provide	VERB
aiua-12464	68	15	as	as	ADP
aiua-12464	68	16	input	input	NOUN
aiua-12464	68	17	and	and	CCONJ
aiua-12464	68	18	figure	figure	NOUN
aiua-12464	68	19	1	1	NUM
aiua-12464	68	20	.	.	PUNCT
aiua-12464	69	1	(	(	PUNCT
aiua-12464	69	2	a	a	X
aiua-12464	69	3	)	)	PUNCT
aiua-12464	69	4	sequence	sequence	NOUN
aiua-12464	69	5	alignment	alignment	NOUN
aiua-12464	69	6	of	of	ADP
aiua-12464	69	7	exon10	exon10	NOUN
aiua-12464	69	8	-	-	PUNCT
aiua-12464	69	9	control	control	NOUN
aiua-12464	69	10	,	,	PUNCT
aiua-12464	69	11	hwp3	hwp3	PROPN
aiua-12464	69	12	,	,	PUNCT
aiua-12464	69	13	hwp4	hwp4	PROPN
aiua-12464	69	14	,	,	PUNCT
aiua-12464	69	15	hwp12	hwp12	PROPN
aiua-12464	69	16	and	and	CCONJ
aiua-12464	69	17	hwp14	hwp14	PROPN
aiua-12464	69	18	:	:	PUNCT
aiua-12464	69	19	rectangular	rectangular	PROPN
aiua-12464	69	20	box	box	PROPN
aiua-12464	69	21	indicates	indicate	VERB
aiua-12464	69	22	the	the	DET
aiua-12464	69	23	region	region	NOUN
aiua-12464	69	24	expanded	expand	VERB
aiua-12464	69	25	to	to	PART
aiua-12464	69	26	visualize	visualize	VERB
aiua-12464	69	27	dna	dna	PROPN
aiua-12464	69	28	sequence	sequence	NOUN
aiua-12464	69	29	quality	quality	NOUN
aiua-12464	69	30	.	.	PUNCT
aiua-12464	70	1	(	(	PUNCT
aiua-12464	70	2	b	b	X
aiua-12464	70	3	)	)	PUNCT
aiua-12464	70	4	comparison	comparison	NOUN
aiua-12464	70	5	of	of	ADP
aiua-12464	70	6	control	control	NOUN
aiua-12464	70	7	and	and	CCONJ
aiua-12464	70	8	sample	sample	NOUN
aiua-12464	70	9	dna	dna	NOUN
aiua-12464	70	10	sequence	sequence	NOUN
aiua-12464	70	11	with	with	ADP
aiua-12464	70	12	their	their	PRON
aiua-12464	70	13	corresponding	corresponding	ADJ
aiua-12464	70	14	in	in	ADP
aiua-12464	70	15	-	-	PUNCT
aiua-12464	70	16	frame	frame	NOUN
aiua-12464	70	17	amino	amino	NOUN
aiua-12464	70	18	acid	acid	NOUN
aiua-12464	70	19	sequences	sequence	NOUN
aiua-12464	70	20	.	.	PUNCT
aiua-12464	71	1	c	c	NOUN
aiua-12464	71	2	and	and	CCONJ
aiua-12464	71	3	s	s	PROPN
aiua-12464	71	4	represent	represent	VERB
aiua-12464	71	5	control	control	NOUN
aiua-12464	71	6	and	and	CCONJ
aiua-12464	71	7	sample	sample	NOUN
aiua-12464	71	8	sequence	sequence	NOUN
aiua-12464	71	9	figure	figure	NOUN
aiua-12464	71	10	2	2	NUM
aiua-12464	71	11	.	.	PUNCT
aiua-12464	72	1	(	(	PUNCT
aiua-12464	72	2	a	a	X
aiua-12464	72	3	)	)	PUNCT
aiua-12464	72	4	sequence	sequence	NOUN
aiua-12464	72	5	analysis	analysis	NOUN
aiua-12464	72	6	of	of	ADP
aiua-12464	72	7	hwp6	hwp6	PROPN
aiua-12464	72	8	,	,	PUNCT
aiua-12464	72	9	(	(	PUNCT
aiua-12464	72	10	*	*	PUNCT
aiua-12464	72	11	)	)	PUNCT
aiua-12464	72	12	indicate	indicate	VERB
aiua-12464	72	13	the	the	DET
aiua-12464	72	14	last	last	ADJ
aiua-12464	72	15	base	base	NOUN
aiua-12464	72	16	pair	pair	NOUN
aiua-12464	72	17	of	of	ADP
aiua-12464	72	18	exon	exon	NOUN
aiua-12464	72	19	10	10	NUM
aiua-12464	72	20	and	and	CCONJ
aiua-12464	72	21	protein	protein	NOUN
aiua-12464	72	22	sequence	sequence	NOUN
aiua-12464	72	23	comparison	comparison	NOUN
aiua-12464	72	24	with	with	ADP
aiua-12464	72	25	control	control	NOUN
aiua-12464	72	26	.	.	PUNCT
aiua-12464	73	1	(	(	PUNCT
aiua-12464	73	2	b	b	PROPN
aiua-12464	73	3	&	&	CCONJ
aiua-12464	73	4	c	c	NOUN
aiua-12464	73	5	)	)	PUNCT
aiua-12464	73	6	dna	dna	NOUN
aiua-12464	73	7	and	and	CCONJ
aiua-12464	73	8	protein	protein	NOUN
aiua-12464	73	9	sequence	sequence	NOUN
aiua-12464	73	10	comparison	comparison	NOUN
aiua-12464	73	11	of	of	ADP
aiua-12464	73	12	missense	missense	NOUN
aiua-12464	73	13	mutations	mutation	NOUN
aiua-12464	73	14	.	.	PUNCT
aiua-12464	74	1	c	c	NOUN
aiua-12464	74	2	and	and	CCONJ
aiua-12464	74	3	s	s	VERB
aiua-12464	74	4	indicate	indicate	VERB
aiua-12464	74	5	control	control	NOUN
aiua-12464	74	6	and	and	CCONJ
aiua-12464	74	7	sample	sample	NOUN
aiua-12464	74	8	sequence	sequence	NOUN
aiua-12464	74	9	respectively	respectively	ADV
aiua-12464	74	10	.	.	PUNCT
aiua-12464	75	1	archivio	archivio	NOUN
aiua-12464	75	2	italiano	italiano	PROPN
aiua-12464	75	3	di	di	PROPN
aiua-12464	75	4	urologia	urologia	PROPN
aiua-12464	75	5	e	e	PROPN
aiua-12464	75	6	andrologia	andrologia	NOUN
aiua-12464	75	7	2024	2024	NUM
aiua-12464	75	8	;	;	PUNCT
aiua-12464	75	9	96(3):12464	96(3):12464	NUM
aiua-12464	75	10	k.	k.	PROPN
aiua-12464	75	11	bakhat	bakhat	PROPN
aiua-12464	75	12	,	,	PUNCT
aiua-12464	75	13	i.	i.	PROPN
aiua-12464	75	14	mateen	mateen	PROPN
aiua-12464	75	15	,	,	PUNCT
aiua-12464	75	16	h.	h.	PROPN
aiua-12464	75	17	saif	saif	PROPN
aiua-12464	75	18	,	,	PUNCT
aiua-12464	75	19	et	et	PROPN
aiua-12464	75	20	al	al	PROPN
aiua-12464	75	21	.	.	PROPN
aiua-12464	75	22	4	4	NUM
aiua-12464	75	23	hope	hope	NOUN
aiua-12464	75	24	provided	provide	VERB
aiua-12464	75	25	insights	insight	NOUN
aiua-12464	75	26	into	into	ADP
aiua-12464	75	27	the	the	DET
aiua-12464	75	28	potential	potential	ADJ
aiua-12464	75	29	consequences	consequence	NOUN
aiua-12464	75	30	of	of	ADP
aiua-12464	75	31	mutations	mutation	NOUN
aiua-12464	75	32	via	via	ADP
aiua-12464	75	33	integration	integration	NOUN
aiua-12464	75	34	of	of	ADP
aiua-12464	75	35	various	various	ADJ
aiua-12464	75	36	computational	computational	ADJ
aiua-12464	75	37	approaches	approach	NOUN
aiua-12464	75	38	(	(	PUNCT
aiua-12464	75	39	19	19	NUM
aiua-12464	75	40	)	)	PUNCT
aiua-12464	75	41	.	.	PUNCT
aiua-12464	76	1	analysis	analysis	NOUN
aiua-12464	76	2	of	of	ADP
aiua-12464	76	3	missense	missense	NOUN
aiua-12464	76	4	mutations	mutation	NOUN
aiua-12464	76	5	on	on	ADP
aiua-12464	76	6	protein	protein	NOUN
aiua-12464	76	7	stability	stability	NOUN
aiua-12464	76	8	and	and	CCONJ
aiua-12464	76	9	functional	functional	ADJ
aiua-12464	76	10	outcomes	outcome	NOUN
aiua-12464	76	11	to	to	PART
aiua-12464	76	12	understand	understand	VERB
aiua-12464	76	13	the	the	DET
aiua-12464	76	14	potential	potential	ADJ
aiua-12464	76	15	out	out	ADJ
aiua-12464	76	16	-	-	PUNCT
aiua-12464	76	17	turn	turn	NOUN
aiua-12464	76	18	of	of	ADP
aiua-12464	76	19	mutations	mutation	NOUN
aiua-12464	76	20	on	on	ADP
aiua-12464	76	21	protein	protein	NOUN
aiua-12464	76	22	stability	stability	NOUN
aiua-12464	76	23	and	and	CCONJ
aiua-12464	76	24	functions	function	NOUN
aiua-12464	76	25	,	,	PUNCT
aiua-12464	76	26	five	five	NUM
aiua-12464	76	27	different	different	ADJ
aiua-12464	76	28	in	in	ADP
aiua-12464	76	29	silico	silico	NOUN
aiua-12464	76	30	tools	tool	NOUN
aiua-12464	76	31	were	be	AUX
aiua-12464	76	32	used	use	VERB
aiua-12464	76	33	.	.	PUNCT
aiua-12464	77	1	polyphen-2	polyphen-2	X
aiua-12464	77	2	(	(	PUNCT
aiua-12464	77	3	20	20	NUM
aiua-12464	77	4	)	)	PUNCT
aiua-12464	77	5	and	and	CCONJ
aiua-12464	77	6	sift	sift	VERB
aiua-12464	77	7	(	(	PUNCT
aiua-12464	77	8	21	21	NUM
aiua-12464	77	9	)	)	PUNCT
aiua-12464	77	10	were	be	AUX
aiua-12464	77	11	used	use	VERB
aiua-12464	77	12	to	to	PART
aiua-12464	77	13	find	find	VERB
aiua-12464	77	14	out	out	ADP
aiua-12464	77	15	the	the	DET
aiua-12464	77	16	harmful	harmful	ADJ
aiua-12464	77	17	effect	effect	NOUN
aiua-12464	77	18	of	of	ADP
aiua-12464	77	19	variants	variant	NOUN
aiua-12464	77	20	whereas	whereas	SCONJ
aiua-12464	77	21	mupro	mupro	ADJ
aiua-12464	77	22	(	(	PUNCT
aiua-12464	77	23	22	22	NUM
aiua-12464	77	24	,	,	PUNCT
aiua-12464	77	25	23	23	NUM
aiua-12464	77	26	)	)	PUNCT
aiua-12464	77	27	,	,	PUNCT
aiua-12464	77	28	cupsat	cupsat	VERB
aiua-12464	77	29	(	(	PUNCT
aiua-12464	77	30	24	24	NUM
aiua-12464	77	31	)	)	PUNCT
aiua-12464	77	32	and	and	CCONJ
aiua-12464	77	33	mcsm	mcsm	NOUN
aiua-12464	77	34	(	(	PUNCT
aiua-12464	77	35	25	25	NUM
aiua-12464	77	36	)	)	PUNCT
aiua-12464	77	37	were	be	AUX
aiua-12464	77	38	used	use	VERB
aiua-12464	77	39	to	to	PART
aiua-12464	77	40	anticipate	anticipate	VERB
aiua-12464	77	41	the	the	DET
aiua-12464	77	42	effects	effect	NOUN
aiua-12464	77	43	of	of	ADP
aiua-12464	77	44	mutagenesis	mutagenesis	NOUN
aiua-12464	77	45	on	on	ADP
aiua-12464	77	46	protein	protein	NOUN
aiua-12464	77	47	stability	stability	NOUN
aiua-12464	77	48	(	(	PUNCT
aiua-12464	77	49	table	table	NOUN
aiua-12464	77	50	2	2	NUM
aiua-12464	77	51	)	)	PUNCT
aiua-12464	77	52	.	.	PUNCT
aiua-12464	78	1	results	result	VERB
aiua-12464	78	2	dna	dna	PROPN
aiua-12464	78	3	sequencing	sequencing	NOUN
aiua-12464	78	4	and	and	CCONJ
aiua-12464	78	5	analysis	analysis	NOUN
aiua-12464	78	6	after	after	ADP
aiua-12464	78	7	a	a	DET
aiua-12464	78	8	quality	quality	NOUN
aiua-12464	78	9	control	control	NOUN
aiua-12464	78	10	with	with	ADP
aiua-12464	78	11	rigorous	rigorous	ADJ
aiua-12464	78	12	selection	selection	NOUN
aiua-12464	78	13	criteria	criterion	NOUN
aiua-12464	78	14	,	,	PUNCT
aiua-12464	78	15	sequencing	sequence	VERB
aiua-12464	78	16	data	datum	NOUN
aiua-12464	78	17	of	of	ADP
aiua-12464	78	18	8	8	NUM
aiua-12464	78	19	patients	patient	NOUN
aiua-12464	78	20	revealed	reveal	VERB
aiua-12464	78	21	that	that	SCONJ
aiua-12464	78	22	4	4	NUM
aiua-12464	78	23	mutations	mutation	NOUN
aiua-12464	78	24	in	in	ADP
aiua-12464	78	25	6	6	NUM
aiua-12464	78	26	individuals	individual	NOUN
aiua-12464	78	27	accounted	account	VERB
aiua-12464	78	28	for	for	ADP
aiua-12464	78	29	35	35	NUM
aiua-12464	78	30	%	%	NOUN
aiua-12464	78	31	of	of	ADP
aiua-12464	78	32	total	total	ADJ
aiua-12464	78	33	17	17	NUM
aiua-12464	78	34	cbavd	cbavd	NOUN
aiua-12464	78	35	patients	patient	NOUN
aiua-12464	78	36	in	in	ADP
aiua-12464	78	37	our	our	PRON
aiua-12464	78	38	experiment	experiment	NOUN
aiua-12464	78	39	.	.	PUNCT
aiua-12464	79	1	all	all	DET
aiua-12464	79	2	these	these	DET
aiua-12464	79	3	mutations	mutation	NOUN
aiua-12464	79	4	were	be	AUX
aiua-12464	79	5	present	present	ADJ
aiua-12464	79	6	on	on	ADP
aiua-12464	79	7	exon	exon	NOUN
aiua-12464	79	8	10	10	NUM
aiua-12464	79	9	while	while	SCONJ
aiua-12464	79	10	we	we	PRON
aiua-12464	79	11	did	do	AUX
aiua-12464	79	12	n’t	not	PART
aiua-12464	79	13	find	find	VERB
aiua-12464	79	14	any	any	DET
aiua-12464	79	15	significant	significant	ADJ
aiua-12464	79	16	mutation	mutation	NOUN
aiua-12464	79	17	in	in	ADP
aiua-12464	79	18	the	the	DET
aiua-12464	79	19	promoter	promoter	NOUN
aiua-12464	79	20	region	region	NOUN
aiua-12464	79	21	of	of	ADP
aiua-12464	79	22	cftr	cftr	NOUN
aiua-12464	79	23	in	in	ADP
aiua-12464	79	24	the	the	DET
aiua-12464	79	25	above	above	ADJ
aiua-12464	79	26	cohort	cohort	NOUN
aiua-12464	79	27	.	.	PUNCT
aiua-12464	80	1	of	of	ADP
aiua-12464	80	2	these	these	DET
aiua-12464	80	3	four	four	NUM
aiua-12464	80	4	identified	identify	VERB
aiua-12464	80	5	mutations	mutation	NOUN
aiua-12464	80	6	,	,	PUNCT
aiua-12464	80	7	two	two	NUM
aiua-12464	80	8	were	be	AUX
aiua-12464	80	9	missense	missense	NOUN
aiua-12464	80	10	mutations	mutation	NOUN
aiua-12464	80	11	(	(	PUNCT
aiua-12464	80	12	v456a	v456a	PROPN
aiua-12464	80	13	,	,	PUNCT
aiua-12464	80	14	k464e	k464e	PROPN
aiua-12464	80	15	)	)	PUNCT
aiua-12464	80	16	whereas	whereas	SCONJ
aiua-12464	80	17	the	the	DET
aiua-12464	80	18	other	other	ADJ
aiua-12464	80	19	two	two	NUM
aiua-12464	80	20	were	be	AUX
aiua-12464	80	21	silent	silent	ADJ
aiua-12464	80	22	mutations	mutation	NOUN
aiua-12464	80	23	(	(	PUNCT
aiua-12464	80	24	g437	g437	PROPN
aiua-12464	80	25	g	g	NOUN
aiua-12464	80	26	,	,	PUNCT
aiua-12464	80	27	s431s	s431s	NUM
aiua-12464	80	28	)	)	PUNCT
aiua-12464	80	29	.	.	PUNCT
aiua-12464	81	1	v456a	v456a	PROPN
aiua-12464	81	2	is	be	AUX
aiua-12464	81	3	an	an	DET
aiua-12464	81	4	important	important	ADJ
aiua-12464	81	5	missense	missense	NOUN
aiua-12464	81	6	variant	variant	NOUN
aiua-12464	81	7	identified	identify	VERB
aiua-12464	81	8	in	in	ADP
aiua-12464	81	9	four	four	NUM
aiua-12464	81	10	patients	patient	NOUN
aiua-12464	81	11	(	(	PUNCT
aiua-12464	81	12	hwp3	hwp3	PROPN
aiua-12464	81	13	,	,	PUNCT
aiua-12464	81	14	hwp4	hwp4	PROPN
aiua-12464	81	15	,	,	PUNCT
aiua-12464	81	16	hwp12	hwp12	PROPN
aiua-12464	81	17	and	and	CCONJ
aiua-12464	81	18	hwp14	hwp14	PROPN
aiua-12464	81	19	)	)	PUNCT
aiua-12464	81	20	of	of	ADP
aiua-12464	81	21	our	our	PRON
aiua-12464	81	22	study	study	NOUN
aiua-12464	81	23	cohort	cohort	NOUN
aiua-12464	81	24	(	(	PUNCT
aiua-12464	81	25	figure	figure	NOUN
aiua-12464	81	26	1a	1a	NOUN
aiua-12464	81	27	)	)	PUNCT
aiua-12464	81	28	.	.	PUNCT
aiua-12464	82	1	nucleotide	nucleotide	ADJ
aiua-12464	82	2	sequences	sequence	NOUN
aiua-12464	82	3	of	of	ADP
aiua-12464	82	4	these	these	DET
aiua-12464	82	5	patients	patient	NOUN
aiua-12464	82	6	contain	contain	VERB
aiua-12464	82	7	base	base	NOUN
aiua-12464	82	8	substitution	substitution	NOUN
aiua-12464	82	9	at	at	ADP
aiua-12464	82	10	position	position	NOUN
aiua-12464	82	11	158	158	NUM
aiua-12464	82	12	of	of	ADP
aiua-12464	82	13	exon	exon	NOUN
aiua-12464	82	14	10	10	NUM
aiua-12464	82	15	where	where	SCONJ
aiua-12464	82	16	t	t	PROPN
aiua-12464	82	17	is	be	AUX
aiua-12464	82	18	replaced	replace	VERB
aiua-12464	82	19	by	by	ADP
aiua-12464	82	20	c	c	NOUN
aiua-12464	82	21	resulting	result	VERB
aiua-12464	82	22	in	in	ADP
aiua-12464	82	23	change	change	NOUN
aiua-12464	82	24	in	in	ADP
aiua-12464	82	25	amino	amino	NOUN
aiua-12464	82	26	acid	acid	NOUN
aiua-12464	82	27	valine	valine	NOUN
aiua-12464	82	28	to	to	ADP
aiua-12464	82	29	alanine	alanine	NOUN
aiua-12464	82	30	(	(	PUNCT
aiua-12464	82	31	figure	figure	NOUN
aiua-12464	82	32	1b	1b	NUM
aiua-12464	82	33	)	)	PUNCT
aiua-12464	82	34	.	.	PUNCT
aiua-12464	83	1	previously	previously	ADV
aiua-12464	83	2	,	,	PUNCT
aiua-12464	83	3	v456a	v456a	PROPN
aiua-12464	83	4	was	be	AUX
aiua-12464	83	5	reported	report	VERB
aiua-12464	83	6	in	in	ADP
aiua-12464	83	7	the	the	DET
aiua-12464	83	8	south	south	ADJ
aiua-12464	83	9	asian	asian	ADJ
aiua-12464	83	10	population	population	NOUN
aiua-12464	83	11	as	as	ADP
aiua-12464	83	12	a	a	DET
aiua-12464	83	13	cf	cf	NOUN
aiua-12464	83	14	causing	cause	VERB
aiua-12464	83	15	variant	variant	NOUN
aiua-12464	83	16	.	.	PUNCT
aiua-12464	84	1	furthermore	furthermore	ADV
aiua-12464	84	2	,	,	PUNCT
aiua-12464	84	3	its	its	PRON
aiua-12464	84	4	association	association	NOUN
aiua-12464	84	5	with	with	ADP
aiua-12464	84	6	male	male	ADJ
aiua-12464	84	7	infertility	infertility	NOUN
aiua-12464	84	8	of	of	ADP
aiua-12464	84	9	cbavd	cbavd	NOUN
aiua-12464	84	10	individuals	individual	NOUN
aiua-12464	84	11	has	have	AUX
aiua-12464	84	12	been	be	AUX
aiua-12464	84	13	established	establish	VERB
aiua-12464	84	14	.	.	PUNCT
aiua-12464	85	1	however	however	ADV
aiua-12464	85	2	,	,	PUNCT
aiua-12464	85	3	other	other	ADJ
aiua-12464	85	4	identified	identify	VERB
aiua-12464	85	5	mutations	mutation	NOUN
aiua-12464	85	6	were	be	AUX
aiua-12464	85	7	novel	novel	ADJ
aiua-12464	85	8	and	and	CCONJ
aiua-12464	85	9	found	find	VERB
aiua-12464	85	10	only	only	ADV
aiua-12464	85	11	in	in	ADP
aiua-12464	85	12	one	one	NUM
aiua-12464	85	13	patient	patient	NOUN
aiua-12464	85	14	each	each	PRON
aiua-12464	85	15	.	.	PUNCT
aiua-12464	86	1	another	another	DET
aiua-12464	86	2	important	important	ADJ
aiua-12464	86	3	point	point	NOUN
aiua-12464	86	4	mutation	mutation	NOUN
aiua-12464	86	5	k464e	k464e	PRON
aiua-12464	86	6	has	have	AUX
aiua-12464	86	7	been	be	AUX
aiua-12464	86	8	identified	identify	VERB
aiua-12464	86	9	in	in	ADP
aiua-12464	86	10	one	one	NUM
aiua-12464	86	11	patient	patient	NOUN
aiua-12464	86	12	(	(	PUNCT
aiua-12464	86	13	hwp6	hwp6	PROPN
aiua-12464	86	14	)	)	PUNCT
aiua-12464	86	15	.	.	PUNCT
aiua-12464	87	1	we	we	PRON
aiua-12464	87	2	observed	observe	VERB
aiua-12464	87	3	base	base	NOUN
aiua-12464	87	4	substitution	substitution	NOUN
aiua-12464	87	5	a	a	PRON
aiua-12464	87	6	to	to	ADP
aiua-12464	87	7	g	g	NOUN
aiua-12464	87	8	mutation	mutation	NOUN
aiua-12464	87	9	at	at	ADP
aiua-12464	87	10	position	position	NOUN
aiua-12464	87	11	181	181	NUM
aiua-12464	87	12	of	of	ADP
aiua-12464	87	13	exon	exon	PROPN
aiua-12464	87	14	10	10	NUM
aiua-12464	87	15	which	which	PRON
aiua-12464	87	16	changed	change	VERB
aiua-12464	87	17	amino	amino	NOUN
aiua-12464	87	18	acid	acid	NOUN
aiua-12464	87	19	lysine	lysine	NOUN
aiua-12464	87	20	(	(	PUNCT
aiua-12464	87	21	k	k	NOUN
aiua-12464	87	22	)	)	PUNCT
aiua-12464	87	23	to	to	ADP
aiua-12464	87	24	glutamic	glutamic	ADJ
aiua-12464	87	25	acid	acid	NOUN
aiua-12464	87	26	(	(	PUNCT
aiua-12464	87	27	e	e	NOUN
aiua-12464	87	28	)	)	PUNCT
aiua-12464	87	29	(	(	PUNCT
aiua-12464	87	30	figure	figure	NOUN
aiua-12464	87	31	2a	2a	NUM
aiua-12464	87	32	)	)	PUNCT
aiua-12464	87	33	.	.	PUNCT
aiua-12464	88	1	it	it	PRON
aiua-12464	88	2	is	be	AUX
aiua-12464	88	3	important	important	ADJ
aiua-12464	88	4	to	to	PART
aiua-12464	88	5	note	note	VERB
aiua-12464	88	6	that	that	SCONJ
aiua-12464	88	7	the	the	DET
aiua-12464	88	8	total	total	ADJ
aiua-12464	88	9	length	length	NOUN
aiua-12464	88	10	of	of	ADP
aiua-12464	88	11	exon	exon	NOUN
aiua-12464	88	12	10	10	NUM
aiua-12464	88	13	is	be	AUX
aiua-12464	88	14	183	183	NUM
aiua-12464	88	15	base	base	NOUN
aiua-12464	88	16	pairs	pair	NOUN
aiua-12464	88	17	and	and	CCONJ
aiua-12464	88	18	the	the	DET
aiua-12464	88	19	integrity	integrity	NOUN
aiua-12464	88	20	of	of	ADP
aiua-12464	88	21	dna	dna	PROPN
aiua-12464	88	22	sequence	sequence	NOUN
aiua-12464	88	23	near	near	ADP
aiua-12464	88	24	the	the	DET
aiua-12464	88	25	splice	splice	NOUN
aiua-12464	88	26	site	site	NOUN
aiua-12464	88	27	is	be	AUX
aiua-12464	88	28	critical	critical	ADJ
aiua-12464	88	29	for	for	SCONJ
aiua-12464	88	30	rna	rna	NOUN
aiua-12464	88	31	splicing	splicing	NOUN
aiua-12464	88	32	machinery	machinery	NOUN
aiua-12464	88	33	to	to	PART
aiua-12464	88	34	function	function	VERB
aiua-12464	88	35	normally	normally	ADV
aiua-12464	88	36	.	.	PUNCT
aiua-12464	89	1	therefore	therefore	ADV
aiua-12464	89	2	,	,	PUNCT
aiua-12464	89	3	in	in	ADP
aiua-12464	89	4	addition	addition	NOUN
aiua-12464	89	5	to	to	ADP
aiua-12464	89	6	its	its	PRON
aiua-12464	89	7	impact	impact	NOUN
aiua-12464	89	8	due	due	ADP
aiua-12464	89	9	to	to	ADP
aiua-12464	89	10	change	change	VERB
aiua-12464	89	11	in	in	ADP
aiua-12464	89	12	amino	amino	NOUN
aiua-12464	89	13	acid	acid	NOUN
aiua-12464	89	14	,	,	PUNCT
aiua-12464	89	15	k464e	k464e	PROPN
aiua-12464	89	16	can	can	AUX
aiua-12464	89	17	interrupt	interrupt	VERB
aiua-12464	89	18	spliceosome	spliceosome	NOUN
aiua-12464	89	19	activity	activity	NOUN
aiua-12464	89	20	at	at	ADP
aiua-12464	89	21	post	post	ADJ
aiua-12464	89	22	-	-	ADJ
aiua-12464	89	23	transcriptional	transcriptional	ADJ
aiua-12464	89	24	level	level	NOUN
aiua-12464	89	25	leading	lead	VERB
aiua-12464	89	26	to	to	ADP
aiua-12464	89	27	excessive	excessive	ADJ
aiua-12464	89	28	loss	loss	NOUN
aiua-12464	89	29	of	of	ADP
aiua-12464	89	30	function	function	NOUN
aiua-12464	89	31	.	.	PUNCT
aiua-12464	90	1	v456a	v456a	PROPN
aiua-12464	90	2	and	and	CCONJ
aiua-12464	90	3	k464e	k464e	PROPN
aiua-12464	90	4	are	be	AUX
aiua-12464	90	5	present	present	ADJ
aiua-12464	90	6	on	on	ADP
aiua-12464	90	7	the	the	DET
aiua-12464	90	8	nbd1	nbd1	PROPN
aiua-12464	90	9	domain	domain	NOUN
aiua-12464	90	10	of	of	ADP
aiua-12464	90	11	cftr	cftr	PROPN
aiua-12464	90	12	(	(	PUNCT
aiua-12464	90	13	26	26	NUM
aiua-12464	90	14	)	)	PUNCT
aiua-12464	90	15	which	which	PRON
aiua-12464	90	16	is	be	AUX
aiua-12464	90	17	crucial	crucial	ADJ
aiua-12464	90	18	for	for	ADP
aiua-12464	90	19	atp	atp	NOUN
aiua-12464	90	20	hydrolysis	hydrolysis	NOUN
aiua-12464	90	21	for	for	ADP
aiua-12464	90	22	normal	normal	ADJ
aiua-12464	90	23	channel	channel	NOUN
aiua-12464	90	24	function	function	NOUN
aiua-12464	90	25	(	(	PUNCT
aiua-12464	90	26	27	27	NUM
aiua-12464	90	27	)	)	PUNCT
aiua-12464	90	28	.	.	PUNCT
aiua-12464	91	1	interestingly	interestingly	ADV
aiua-12464	91	2	,	,	PUNCT
aiua-12464	91	3	in	in	ADP
aiua-12464	91	4	addition	addition	NOUN
aiua-12464	91	5	to	to	ADP
aiua-12464	91	6	v456a	v456a	PROPN
aiua-12464	91	7	,	,	PUNCT
aiua-12464	91	8	patient	patient	ADJ
aiua-12464	91	9	hwp14	hwp14	NOUN
aiua-12464	91	10	contains	contain	VERB
aiua-12464	91	11	a	a	DET
aiua-12464	91	12	silent	silent	ADJ
aiua-12464	91	13	mutation	mutation	NOUN
aiua-12464	91	14	s431s	s431s	PROPN
aiua-12464	91	15	(	(	PUNCT
aiua-12464	91	16	figure	figure	NOUN
aiua-12464	91	17	2b	2b	NOUN
aiua-12464	91	18	)	)	PUNCT
aiua-12464	91	19	.	.	PUNCT
aiua-12464	92	1	this	this	DET
aiua-12464	92	2	additional	additional	ADJ
aiua-12464	92	3	mutation	mutation	NOUN
aiua-12464	92	4	does	do	AUX
aiua-12464	92	5	not	not	PART
aiua-12464	92	6	affect	affect	VERB
aiua-12464	92	7	the	the	DET
aiua-12464	92	8	nature	nature	NOUN
aiua-12464	92	9	of	of	ADP
aiua-12464	92	10	the	the	DET
aiua-12464	92	11	amino	amino	NOUN
aiua-12464	92	12	acid	acid	NOUN
aiua-12464	92	13	.	.	PUNCT
aiua-12464	93	1	another	another	DET
aiua-12464	93	2	silent	silent	ADJ
aiua-12464	93	3	mutation	mutation	NOUN
aiua-12464	93	4	g437	g437	PROPN
aiua-12464	93	5	g	g	PROPN
aiua-12464	93	6	has	have	AUX
aiua-12464	93	7	been	be	AUX
aiua-12464	93	8	detected	detect	VERB
aiua-12464	93	9	at	at	ADP
aiua-12464	93	10	position	position	NOUN
aiua-12464	93	11	102	102	NUM
aiua-12464	93	12	of	of	ADP
aiua-12464	93	13	exon	exon	NOUN
aiua-12464	93	14	10	10	NUM
aiua-12464	93	15	in	in	ADP
aiua-12464	93	16	hwp13	hwp13	PROPN
aiua-12464	93	17	(	(	PUNCT
aiua-12464	93	18	figure	figure	NOUN
aiua-12464	93	19	2c	2c	NUM
aiua-12464	93	20	)	)	PUNCT
aiua-12464	93	21	.	.	PUNCT
aiua-12464	94	1	these	these	DET
aiua-12464	94	2	two	two	NUM
aiua-12464	94	3	silent	silent	ADJ
aiua-12464	94	4	mutations	mutation	NOUN
aiua-12464	94	5	are	be	AUX
aiua-12464	94	6	irrelevant	irrelevant	ADJ
aiua-12464	94	7	in	in	ADP
aiua-12464	94	8	the	the	DET
aiua-12464	94	9	perspective	perspective	NOUN
aiua-12464	94	10	of	of	ADP
aiua-12464	94	11	protein	protein	NOUN
aiua-12464	94	12	function	function	NOUN
aiua-12464	94	13	but	but	CCONJ
aiua-12464	94	14	can	can	AUX
aiua-12464	94	15	influence	influence	VERB
aiua-12464	94	16	single	single	ADJ
aiua-12464	94	17	nucleotide	nucleotide	NOUN
aiua-12464	94	18	polymorphism	polymorphism	NOUN
aiua-12464	94	19	(	(	PUNCT
aiua-12464	94	20	snp	snp	ADJ
aiua-12464	94	21	)	)	PUNCT
aiua-12464	94	22	.	.	PUNCT
aiua-12464	95	1	frequency	frequency	NOUN
aiua-12464	95	2	and	and	CCONJ
aiua-12464	95	3	mutation	mutation	NOUN
aiua-12464	95	4	spectrum	spectrum	NOUN
aiua-12464	95	5	of	of	ADP
aiua-12464	95	6	cftr	cftr	NOUN
aiua-12464	95	7	is	be	AUX
aiua-12464	95	8	variable	variable	ADJ
aiua-12464	95	9	and	and	CCONJ
aiua-12464	95	10	known	know	VERB
aiua-12464	95	11	to	to	PART
aiua-12464	95	12	be	be	AUX
aiua-12464	95	13	confined	confine	VERB
aiua-12464	95	14	within	within	ADP
aiua-12464	95	15	different	different	ADJ
aiua-12464	95	16	ethnic	ethnic	ADJ
aiua-12464	95	17	groups	group	NOUN
aiua-12464	95	18	.	.	PUNCT
aiua-12464	96	1	in	in	ADP
aiua-12464	96	2	this	this	DET
aiua-12464	96	3	study	study	NOUN
aiua-12464	96	4	,	,	PUNCT
aiua-12464	96	5	we	we	PRON
aiua-12464	96	6	have	have	AUX
aiua-12464	96	7	found	find	VERB
aiua-12464	96	8	genetic	genetic	ADJ
aiua-12464	96	9	mutations	mutation	NOUN
aiua-12464	96	10	on	on	ADP
aiua-12464	96	11	critically	critically	ADV
aiua-12464	96	12	functional	functional	ADJ
aiua-12464	96	13	locations	location	NOUN
aiua-12464	96	14	of	of	ADP
aiua-12464	96	15	cftr	cftr	NOUN
aiua-12464	96	16	in	in	ADP
aiua-12464	96	17	cbavd	cbavd	NOUN
aiua-12464	96	18	patients	patient	NOUN
aiua-12464	96	19	(	(	PUNCT
aiua-12464	96	20	table	table	NOUN
aiua-12464	96	21	s2	s2	NOUN
aiua-12464	96	22	supplementary	supplementary	ADJ
aiua-12464	96	23	materials	material	NOUN
aiua-12464	96	24	)	)	PUNCT
aiua-12464	96	25	.	.	PUNCT
aiua-12464	97	1	the	the	DET
aiua-12464	97	2	recurrence	recurrence	NOUN
aiua-12464	97	3	of	of	ADP
aiua-12464	97	4	v456a	v456a	PROPN
aiua-12464	97	5	mutation	mutation	NOUN
aiua-12464	97	6	in	in	ADP
aiua-12464	97	7	four	four	NUM
aiua-12464	97	8	cbavd	cbavd	NOUN
aiua-12464	97	9	patients	patient	NOUN
aiua-12464	97	10	highlights	highlight	VERB
aiua-12464	97	11	its	its	PRON
aiua-12464	97	12	potential	potential	ADJ
aiua-12464	97	13	role	role	NOUN
aiua-12464	97	14	in	in	ADP
aiua-12464	97	15	disease	disease	NOUN
aiua-12464	97	16	and	and	CCONJ
aiua-12464	97	17	diagnosis	diagnosis	NOUN
aiua-12464	97	18	.	.	PUNCT
aiua-12464	98	1	mutation	mutation	NOUN
aiua-12464	98	2	k464e	k464e	PRON
aiua-12464	98	3	is	be	AUX
aiua-12464	98	4	crucial	crucial	ADJ
aiua-12464	98	5	due	due	ADP
aiua-12464	98	6	to	to	ADP
aiua-12464	98	7	its	its	PRON
aiua-12464	98	8	location	location	NOUN
aiua-12464	98	9	and	and	CCONJ
aiua-12464	98	10	is	be	AUX
aiua-12464	98	11	capable	capable	ADJ
aiua-12464	98	12	of	of	ADP
aiua-12464	98	13	affecting	affect	VERB
aiua-12464	98	14	cftr	cftr	NOUN
aiua-12464	98	15	function	function	NOUN
aiua-12464	98	16	drastically	drastically	ADV
aiua-12464	98	17	.	.	PUNCT
aiua-12464	99	1	structural	structural	ADJ
aiua-12464	99	2	visualization	visualization	NOUN
aiua-12464	99	3	of	of	ADP
aiua-12464	99	4	cftr	cftr	NOUN
aiua-12464	99	5	protein	protein	NOUN
aiua-12464	99	6	and	and	CCONJ
aiua-12464	99	7	in	in	ADP
aiua-12464	99	8	silico	silico	NOUN
aiua-12464	99	9	analysis	analysis	NOUN
aiua-12464	99	10	of	of	ADP
aiua-12464	99	11	identified	identify	VERB
aiua-12464	99	12	mutations	mutation	NOUN
aiua-12464	99	13	in	in	ADP
aiua-12464	99	14	exon	exon	NOUN
aiua-12464	99	15	10	10	NUM
aiua-12464	99	16	we	we	PRON
aiua-12464	99	17	visualize	visualize	VERB
aiua-12464	99	18	the	the	DET
aiua-12464	99	19	structure	structure	NOUN
aiua-12464	99	20	of	of	ADP
aiua-12464	99	21	the	the	DET
aiua-12464	99	22	cftr	cftr	NOUN
aiua-12464	99	23	protein	protein	NOUN
aiua-12464	99	24	(	(	PUNCT
aiua-12464	99	25	pdb	pdb	PROPN
aiua-12464	99	26	i	i	NOUN
aiua-12464	99	27	d	d	PROPN
aiua-12464	99	28	:	:	PUNCT
aiua-12464	99	29	6o1v	6o1v	NUM
aiua-12464	99	30	)	)	PUNCT
aiua-12464	99	31	,	,	PUNCT
aiua-12464	99	32	using	use	VERB
aiua-12464	99	33	pymol	pymol	NOUN
aiua-12464	99	34	software	software	NOUN
aiua-12464	99	35	(	(	PUNCT
aiua-12464	99	36	https://pymol.org/2/	https://pymol.org/2/	PROPN
aiua-12464	99	37	)	)	PUNCT
aiua-12464	99	38	to	to	PART
aiua-12464	99	39	explore	explore	VERB
aiua-12464	99	40	critical	critical	ADJ
aiua-12464	99	41	regions	region	NOUN
aiua-12464	99	42	and	and	CCONJ
aiua-12464	99	43	mutations	mutation	NOUN
aiua-12464	99	44	within	within	ADP
aiua-12464	99	45	exon	exon	NOUN
aiua-12464	99	46	10	10	NUM
aiua-12464	99	47	(	(	PUNCT
aiua-12464	99	48	figure	figure	NOUN
aiua-12464	99	49	s4	s4	PROPN
aiua-12464	99	50	supplementary	supplementary	ADJ
aiua-12464	99	51	materials	material	NOUN
aiua-12464	99	52	)	)	PUNCT
aiua-12464	99	53	.	.	PUNCT
aiua-12464	100	1	the	the	DET
aiua-12464	100	2	orthoscopic	orthoscopic	ADJ
aiua-12464	100	3	view	view	NOUN
aiua-12464	100	4	of	of	ADP
aiua-12464	100	5	cftr	cftr	NOUN
aiua-12464	100	6	provides	provide	VERB
aiua-12464	100	7	an	an	DET
aiua-12464	100	8	overall	overall	ADJ
aiua-12464	100	9	structure	structure	NOUN
aiua-12464	100	10	,	,	PUNCT
aiua-12464	100	11	while	while	SCONJ
aiua-12464	100	12	the	the	DET
aiua-12464	100	13	functional	functional	ADJ
aiua-12464	100	14	site	site	NOUN
aiua-12464	100	15	in	in	ADP
aiua-12464	100	16	exon	exon	PROPN
aiua-12464	100	17	10	10	NUM
aiua-12464	100	18	is	be	AUX
aiua-12464	100	19	highlighted	highlight	VERB
aiua-12464	100	20	in	in	ADP
aiua-12464	100	21	cyan	cyan	NOUN
aiua-12464	100	22	(	(	PUNCT
aiua-12464	100	23	figure	figure	NOUN
aiua-12464	100	24	s4	s4	PROPN
aiua-12464	100	25	supplementary	supplementary	ADJ
aiua-12464	100	26	materials	material	NOUN
aiua-12464	100	27	)	)	PUNCT
aiua-12464	100	28	.	.	PUNCT
aiua-12464	101	1	within	within	ADP
aiua-12464	101	2	this	this	DET
aiua-12464	101	3	selected	select	VERB
aiua-12464	101	4	region	region	NOUN
aiua-12464	101	5	of	of	ADP
aiua-12464	101	6	exon	exon	PROPN
aiua-12464	101	7	10	10	NUM
aiua-12464	101	8	,	,	PUNCT
aiua-12464	101	9	we	we	PRON
aiua-12464	101	10	pinpoint	pinpoint	VERB
aiua-12464	101	11	three	three	NUM
aiua-12464	101	12	specific	specific	ADJ
aiua-12464	101	13	mutations	mutation	NOUN
aiua-12464	101	14	—	—	PUNCT
aiua-12464	101	15	v456a	v456a	PROPN
aiua-12464	101	16	,	,	PUNCT
aiua-12464	101	17	k464e	k464e	PROPN
aiua-12464	101	18	,	,	PUNCT
aiua-12464	101	19	and	and	CCONJ
aiua-12464	101	20	g437g	g437g	PROPN
aiua-12464	101	21	—	—	PUNCT
aiua-12464	101	22	represented	represent	VERB
aiua-12464	101	23	as	as	ADP
aiua-12464	101	24	sticks	stick	NOUN
aiua-12464	101	25	.	.	PUNCT
aiua-12464	102	1	each	each	DET
aiua-12464	102	2	mutation	mutation	NOUN
aiua-12464	102	3	is	be	AUX
aiua-12464	102	4	labeled	label	VERB
aiua-12464	102	5	with	with	ADP
aiua-12464	102	6	its	its	PRON
aiua-12464	102	7	corresponding	corresponding	ADJ
aiua-12464	102	8	amino	amino	NOUN
aiua-12464	102	9	acid	acid	NOUN
aiua-12464	102	10	change	change	NOUN
aiua-12464	102	11	,	,	PUNCT
aiua-12464	102	12	providing	provide	VERB
aiua-12464	102	13	insight	insight	NOUN
aiua-12464	102	14	into	into	ADP
aiua-12464	102	15	the	the	DET
aiua-12464	102	16	spatial	spatial	ADJ
aiua-12464	102	17	arrangement	arrangement	NOUN
aiua-12464	102	18	of	of	ADP
aiua-12464	102	19	these	these	DET
aiua-12464	102	20	vital	vital	ADJ
aiua-12464	102	21	regions	region	NOUN
aiua-12464	102	22	within	within	ADP
aiua-12464	102	23	the	the	DET
aiua-12464	102	24	protein	protein	NOUN
aiua-12464	102	25	(	(	PUNCT
aiua-12464	102	26	figure	figure	NOUN
aiua-12464	102	27	s4	s4	NOUN
aiua-12464	102	28	,	,	PUNCT
aiua-12464	102	29	d	d	PROPN
aiua-12464	102	30	-	-	PUNCT
aiua-12464	102	31	f	f	PROPN
aiua-12464	102	32	supplementary	supplementary	ADJ
aiua-12464	102	33	materials	material	NOUN
aiua-12464	102	34	)	)	PUNCT
aiua-12464	102	35	.	.	PUNCT
aiua-12464	103	1	consurf	consurf	PROPN
aiua-12464	103	2	identified	identify	VERB
aiua-12464	103	3	v456	v456	PROPN
aiua-12464	103	4	(	(	PUNCT
aiua-12464	103	5	score	score	NOUN
aiua-12464	103	6	:	:	PUNCT
aiua-12464	103	7	7	7	NUM
aiua-12464	103	8	)	)	PUNCT
aiua-12464	103	9	and	and	CCONJ
aiua-12464	103	10	k464	k464	PROPN
aiua-12464	103	11	(	(	PUNCT
aiua-12464	103	12	score	score	NOUN
aiua-12464	103	13	:	:	PUNCT
aiua-12464	103	14	9	9	NUM
aiua-12464	103	15	)	)	PUNCT
aiua-12464	103	16	as	as	SCONJ
aiua-12464	103	17	conserved	conserved	ADJ
aiua-12464	103	18	and	and	CCONJ
aiua-12464	103	19	highly	highly	ADV
aiua-12464	103	20	conserved	conserve	VERB
aiua-12464	103	21	residues	residue	NOUN
aiua-12464	103	22	respectively	respectively	ADV
aiua-12464	103	23	(	(	PUNCT
aiua-12464	103	24	figure	figure	NOUN
aiua-12464	103	25	s5	s5	PROPN
aiua-12464	103	26	supplementary	supplementary	ADJ
aiua-12464	103	27	materials	material	NOUN
aiua-12464	103	28	)	)	PUNCT
aiua-12464	103	29	.	.	PUNCT
aiua-12464	104	1	both	both	DET
aiua-12464	104	2	polyphen-2	polyphen-2	X
aiua-12464	104	3	and	and	CCONJ
aiua-12464	104	4	sift	sift	VERB
aiua-12464	104	5	analyze	analyze	VERB
aiua-12464	104	6	the	the	DET
aiua-12464	104	7	mutations	mutation	NOUN
aiua-12464	104	8	as	as	ADP
aiua-12464	104	9	harmful	harmful	ADJ
aiua-12464	104	10	and	and	CCONJ
aiua-12464	104	11	deleterious	deleterious	ADJ
aiua-12464	104	12	.	.	PUNCT
aiua-12464	105	1	in	in	ADP
aiua-12464	105	2	case	case	NOUN
aiua-12464	105	3	of	of	ADP
aiua-12464	105	4	polyphen-2	polyphen-2	NOUN
aiua-12464	105	5	,	,	PUNCT
aiua-12464	105	6	score	score	NOUN
aiua-12464	105	7	0	0	NUM
aiua-12464	105	8	-	-	SYM
aiua-12464	105	9	0.5	0.5	NUM
aiua-12464	105	10	means	mean	VERB
aiua-12464	105	11	benign	benign	ADJ
aiua-12464	105	12	effect	effect	NOUN
aiua-12464	105	13	and	and	CCONJ
aiua-12464	105	14	above	above	ADP
aiua-12464	105	15	0.5	0.5	NUM
aiua-12464	105	16	is	be	AUX
aiua-12464	105	17	considered	consider	VERB
aiua-12464	105	18	damaging	damaging	ADJ
aiua-12464	105	19	whereas	whereas	SCONJ
aiua-12464	105	20	for	for	ADP
aiua-12464	105	21	sift	sift	ADJ
aiua-12464	105	22	score	score	NOUN
aiua-12464	105	23	0	0	NUM
aiua-12464	105	24	-	-	SYM
aiua-12464	105	25	0.5	0.5	NUM
aiua-12464	105	26	is	be	AUX
aiua-12464	105	27	considered	consider	VERB
aiua-12464	105	28	non	non	ADJ
aiua-12464	105	29	tolerant	tolerant	ADJ
aiua-12464	105	30	and	and	CCONJ
aiua-12464	105	31	close	close	ADJ
aiua-12464	105	32	to	to	ADP
aiua-12464	105	33	1.00	1.00	NUM
aiua-12464	105	34	is	be	AUX
aiua-12464	105	35	allowed	allow	VERB
aiua-12464	105	36	(	(	PUNCT
aiua-12464	105	37	table	table	NOUN
aiua-12464	105	38	1	1	NUM
aiua-12464	105	39	)	)	PUNCT
aiua-12464	105	40	.	.	PUNCT
aiua-12464	106	1	mutational	mutational	ADJ
aiua-12464	106	2	effects	effect	NOUN
aiua-12464	106	3	of	of	ADP
aiua-12464	106	4	mupro	mupro	ADJ
aiua-12464	106	5	,	,	PUNCT
aiua-12464	106	6	cupsat	cupsat	VERB
aiua-12464	106	7	and	and	CCONJ
aiua-12464	106	8	mcsm	mcsm	NOUN
aiua-12464	106	9	suggested	suggest	VERB
aiua-12464	106	10	the	the	DET
aiua-12464	106	11	overall	overall	ADJ
aiua-12464	106	12	mutations	mutation	NOUN
aiua-12464	106	13	resulted	result	VERB
aiua-12464	106	14	in	in	ADP
aiua-12464	106	15	decreased	decrease	VERB
aiua-12464	106	16	stability	stability	NOUN
aiua-12464	106	17	,	,	PUNCT
aiua-12464	106	18	these	these	DET
aiua-12464	106	19	tools	tool	NOUN
aiua-12464	106	20	predict	predict	VERB
aiua-12464	106	21	∆∆g	∆∆g	NOUN
aiua-12464	106	22	(	(	PUNCT
aiua-12464	106	23	kcal	kcal	NOUN
aiua-12464	106	24	/	/	SYM
aiua-12464	106	25	mol	mol	NOUN
aiua-12464	106	26	)	)	PUNCT
aiua-12464	106	27	where	where	SCONJ
aiua-12464	106	28	negative	negative	ADJ
aiua-12464	106	29	value	value	NOUN
aiua-12464	106	30	indicative	indicative	ADJ
aiua-12464	106	31	of	of	ADP
aiua-12464	106	32	destabilizing	destabilizing	ADJ
aiua-12464	106	33	mutation	mutation	NOUN
aiua-12464	106	34	(	(	PUNCT
aiua-12464	106	35	table	table	NOUN
aiua-12464	106	36	2	2	NUM
aiua-12464	106	37	)	)	PUNCT
aiua-12464	106	38	.	.	PUNCT
aiua-12464	107	1	hope	hope	PROPN
aiua-12464	107	2	software	software	PROPN
aiua-12464	107	3	revealed	reveal	VERB
aiua-12464	107	4	structural	structural	ADJ
aiua-12464	107	5	alterations	alteration	NOUN
aiua-12464	107	6	caused	cause	VERB
aiua-12464	107	7	by	by	ADP
aiua-12464	107	8	table	table	NOUN
aiua-12464	107	9	2	2	NUM
aiua-12464	107	10	.	.	PUNCT
aiua-12464	107	11	computational	computational	ADJ
aiua-12464	107	12	analysis	analysis	NOUN
aiua-12464	107	13	of	of	ADP
aiua-12464	107	14	protein	protein	NOUN
aiua-12464	107	15	stability	stability	NOUN
aiua-12464	107	16	in	in	ADP
aiua-12464	107	17	mutants	mutant	NOUN
aiua-12464	107	18	.	.	PUNCT
aiua-12464	108	1	s.	s.	PROPN
aiua-12464	108	2	no	no	INTJ
aiua-12464	108	3	.	.	PUNCT
aiua-12464	109	1	mutation	mutation	NOUN
aiua-12464	109	2	mcsm	mcsm	NOUN
aiua-12464	109	3	cupsat	cupsat	VERB
aiua-12464	109	4	mupro	mupro	ADJ
aiua-12464	109	5	overall	overall	NOUN
aiua-12464	109	6	predicted	predict	VERB
aiua-12464	109	7	δδg	δδg	PROPN
aiua-12464	109	8	overall	overall	ADV
aiua-12464	109	9	predicted	predict	VERB
aiua-12464	109	10	δδg	δδg	PROPN
aiua-12464	109	11	overall	overall	ADV
aiua-12464	109	12	predicted	predict	VERB
aiua-12464	109	13	δδg	δδg	PROPN
aiua-12464	109	14	stability	stability	NOUN
aiua-12464	109	15	(	(	PUNCT
aiua-12464	109	16	kcal	kcal	PROPN
aiua-12464	109	17	/	/	SYM
aiua-12464	109	18	mol	mol	NOUN
aiua-12464	109	19	)	)	PUNCT
aiua-12464	109	20	stability	stability	NOUN
aiua-12464	109	21	(	(	PUNCT
aiua-12464	109	22	kcal	kcal	NOUN
aiua-12464	109	23	/	/	SYM
aiua-12464	109	24	mol	mol	NOUN
aiua-12464	109	25	)	)	PUNCT
aiua-12464	109	26	stability	stability	NOUN
aiua-12464	109	27	(	(	PUNCT
aiua-12464	109	28	kcal	kcal	NOUN
aiua-12464	109	29	/	/	SYM
aiua-12464	109	30	mol	mol	NOUN
aiua-12464	109	31	)	)	PUNCT
aiua-12464	109	32	score	score	NOUN
aiua-12464	109	33	effect	effect	NOUN
aiua-12464	109	34	score	score	NOUN
aiua-12464	109	35	effect	effect	NOUN
aiua-12464	109	36	1	1	NUM
aiua-12464	109	37	v456a	v456a	VERB
aiua-12464	109	38	destabilizing	destabilize	VERB
aiua-12464	109	39	-2.0	-2.0	ADJ
aiua-12464	109	40	destabilizing	destabilizing	ADJ
aiua-12464	109	41	-1.2	-1.2	NOUN
aiua-12464	109	42	destabilizing	destabilizing	NOUN
aiua-12464	109	43	-1.8	-1.8	PROPN
aiua-12464	109	44	2	2	NUM
aiua-12464	109	45	k464e	k464e	ADV
aiua-12464	109	46	destabilizing	destabilize	VERB
aiua-12464	109	47	-0.7	-0.7	ADJ
aiua-12464	109	48	destabilizing	destabilizing	ADJ
aiua-12464	109	49	-2.1	-2.1	NOUN
aiua-12464	109	50	stabilizing	stabilize	VERB
aiua-12464	109	51	0.3	0.3	NUM
aiua-12464	109	52	table	table	NOUN
aiua-12464	109	53	1	1	NUM
aiua-12464	109	54	.	.	PUNCT
aiua-12464	110	1	in	in	ADP
aiua-12464	110	2	silico	silico	NOUN
aiua-12464	110	3	checking	check	VERB
aiua-12464	110	4	for	for	ADP
aiua-12464	110	5	the	the	DET
aiua-12464	110	6	pathogenicity	pathogenicity	NOUN
aiua-12464	110	7	of	of	ADP
aiua-12464	110	8	mutants	mutant	NOUN
aiua-12464	110	9	.	.	PUNCT
aiua-12464	111	1	s.	s.	PROPN
aiua-12464	111	2	no	no	INTJ
aiua-12464	111	3	.	.	PUNCT
aiua-12464	112	1	mutation	mutation	NOUN
aiua-12464	112	2	polyphen-2	polyphen-2	CCONJ
aiua-12464	112	3	sift	sift	VERB
aiua-12464	112	4	score	score	NOUN
aiua-12464	112	5	effect	effect	NOUN
aiua-12464	112	6	score	score	NOUN
aiua-12464	112	7	effect	effect	NOUN
aiua-12464	112	8	1	1	NUM
aiua-12464	112	9	v456a	v456a	PROPN
aiua-12464	112	10	0.989	0.989	NUM
aiua-12464	112	11	probably	probably	ADV
aiua-12464	112	12	damaging	damage	VERB
aiua-12464	112	13	0.01	0.01	NUM
aiua-12464	112	14	intolerant	intolerant	ADJ
aiua-12464	112	15	2	2	NUM
aiua-12464	112	16	k464e	k464e	NOUN
aiua-12464	112	17	0.973	0.973	NUM
aiua-12464	112	18	probably	probably	ADV
aiua-12464	112	19	damaging	damage	VERB
aiua-12464	112	20	0.00	0.00	NUM
aiua-12464	112	21	intolerant	intolerant	ADJ
aiua-12464	112	22	archivio	archivio	NOUN
aiua-12464	112	23	italiano	italiano	NOUN
aiua-12464	112	24	di	di	X
aiua-12464	112	25	urologia	urologia	PROPN
aiua-12464	112	26	e	e	PROPN
aiua-12464	112	27	andrologia	andrologia	NOUN
aiua-12464	112	28	2024	2024	NUM
aiua-12464	112	29	;	;	PUNCT
aiua-12464	112	30	96(3):12464	96(3):12464	NUM
aiua-12464	112	31	5	5	NUM
aiua-12464	112	32	cftr	cftr	NOUN
aiua-12464	112	33	exon	exon	PROPN
aiua-12464	112	34	10	10	NUM
aiua-12464	112	35	mutations	mutation	NOUN
aiua-12464	112	36	and	and	CCONJ
aiua-12464	112	37	congenital	congenital	ADJ
aiua-12464	112	38	bilateral	bilateral	ADJ
aiua-12464	112	39	absence	absence	NOUN
aiua-12464	112	40	of	of	ADP
aiua-12464	112	41	vas	vas	X
aiua-12464	112	42	deferens	deferens	PROPN
aiua-12464	112	43	the	the	DET
aiua-12464	112	44	v456a	v456a	PROPN
aiua-12464	112	45	(	(	PUNCT
aiua-12464	112	46	figure	figure	NOUN
aiua-12464	112	47	3a	3a	NUM
aiua-12464	112	48	)	)	PUNCT
aiua-12464	112	49	and	and	CCONJ
aiua-12464	112	50	k464e	k464e	PROPN
aiua-12464	112	51	(	(	PUNCT
aiua-12464	112	52	figre	figre	VERB
aiua-12464	112	53	3b	3b	NUM
aiua-12464	112	54	)	)	PUNCT
aiua-12464	112	55	mutations	mutation	NOUN
aiua-12464	112	56	.	.	PUNCT
aiua-12464	113	1	these	these	DET
aiua-12464	113	2	visualizations	visualization	NOUN
aiua-12464	113	3	illustrate	illustrate	VERB
aiua-12464	113	4	how	how	SCONJ
aiua-12464	113	5	these	these	DET
aiua-12464	113	6	mutations	mutation	NOUN
aiua-12464	113	7	impact	impact	VERB
aiua-12464	113	8	local	local	ADJ
aiua-12464	113	9	protein	protein	NOUN
aiua-12464	113	10	structure	structure	NOUN
aiua-12464	113	11	,	,	PUNCT
aiua-12464	113	12	providing	provide	VERB
aiua-12464	113	13	insights	insight	NOUN
aiua-12464	113	14	into	into	ADP
aiua-12464	113	15	their	their	PRON
aiua-12464	113	16	functional	functional	ADJ
aiua-12464	113	17	consequences	consequence	NOUN
aiua-12464	113	18	.	.	PUNCT
aiua-12464	114	1	discussion	discussion	NOUN
aiua-12464	114	2	prior	prior	ADJ
aiua-12464	114	3	research	research	NOUN
aiua-12464	114	4	has	have	AUX
aiua-12464	114	5	documented	document	VERB
aiua-12464	114	6	cystic	cystic	ADJ
aiua-12464	114	7	fibrosis	fibrosis	NOUN
aiua-12464	114	8	(	(	PUNCT
aiua-12464	114	9	cf	cf	NOUN
aiua-12464	114	10	)	)	PUNCT
aiua-12464	114	11	as	as	ADP
aiua-12464	114	12	a	a	DET
aiua-12464	114	13	major	major	ADJ
aiua-12464	114	14	autosomal	autosomal	ADJ
aiua-12464	114	15	recessive	recessive	ADJ
aiua-12464	114	16	disease	disease	NOUN
aiua-12464	114	17	in	in	ADP
aiua-12464	114	18	ethnic	ethnic	ADJ
aiua-12464	114	19	groups	group	NOUN
aiua-12464	114	20	.	.	PUNCT
aiua-12464	115	1	moreover	moreover	ADV
aiua-12464	115	2	,	,	PUNCT
aiua-12464	115	3	there	there	PRON
aiua-12464	115	4	are	be	VERB
aiua-12464	115	5	up	up	ADP
aiua-12464	115	6	to	to	ADP
aiua-12464	115	7	2000	2000	NUM
aiua-12464	115	8	cftr	cftr	NOUN
aiua-12464	115	9	mutations	mutation	NOUN
aiua-12464	115	10	that	that	PRON
aiua-12464	115	11	have	have	AUX
aiua-12464	115	12	been	be	AUX
aiua-12464	115	13	reported	report	VERB
aiua-12464	115	14	,	,	PUNCT
aiua-12464	115	15	with	with	ADP
aiua-12464	115	16	variable	variable	ADJ
aiua-12464	115	17	frequencies	frequency	NOUN
aiua-12464	115	18	depending	depend	VERB
aiua-12464	115	19	on	on	ADP
aiua-12464	115	20	ethnic	ethnic	ADJ
aiua-12464	115	21	and	and	CCONJ
aiua-12464	115	22	geographic	geographic	ADJ
aiua-12464	115	23	backgrounds	background	NOUN
aiua-12464	115	24	.	.	PUNCT
aiua-12464	116	1	it	it	PRON
aiua-12464	116	2	is	be	AUX
aiua-12464	116	3	imperative	imperative	ADJ
aiua-12464	116	4	to	to	PART
aiua-12464	116	5	highlight	highlight	VERB
aiua-12464	116	6	the	the	DET
aiua-12464	116	7	various	various	ADJ
aiua-12464	116	8	variables	variable	NOUN
aiua-12464	116	9	of	of	ADP
aiua-12464	116	10	cftr	cftr	NOUN
aiua-12464	116	11	mutations	mutation	NOUN
aiua-12464	116	12	that	that	PRON
aiua-12464	116	13	are	be	AUX
aiua-12464	116	14	prevalent	prevalent	ADJ
aiua-12464	116	15	in	in	ADP
aiua-12464	116	16	a	a	DET
aiua-12464	116	17	given	give	VERB
aiua-12464	116	18	population	population	NOUN
aiua-12464	116	19	to	to	PART
aiua-12464	116	20	help	help	VERB
aiua-12464	116	21	focus	focus	VERB
aiua-12464	116	22	on	on	ADP
aiua-12464	116	23	the	the	DET
aiua-12464	116	24	diagnostic	diagnostic	ADJ
aiua-12464	116	25	test	test	NOUN
aiua-12464	116	26	.	.	PUNCT
aiua-12464	117	1	it	it	PRON
aiua-12464	117	2	’s	’	VERB
aiua-12464	117	3	a	a	DET
aiua-12464	117	4	prerequisite	prerequisite	NOUN
aiua-12464	117	5	for	for	ADP
aiua-12464	117	6	setting	set	VERB
aiua-12464	117	7	up	up	ADP
aiua-12464	117	8	efficient	efficient	ADJ
aiua-12464	117	9	molecular	molecular	ADJ
aiua-12464	117	10	diagnostics	diagnostic	NOUN
aiua-12464	117	11	and	and	CCONJ
aiua-12464	117	12	for	for	ADP
aiua-12464	117	13	furthering	further	VERB
aiua-12464	117	14	the	the	DET
aiua-12464	117	15	genetic	genetic	ADJ
aiua-12464	117	16	treatment	treatment	NOUN
aiua-12464	117	17	to	to	PART
aiua-12464	117	18	help	help	VERB
aiua-12464	117	19	its	its	PRON
aiua-12464	117	20	prevention	prevention	NOUN
aiua-12464	117	21	(	(	PUNCT
aiua-12464	117	22	1	1	NUM
aiua-12464	117	23	)	)	PUNCT
aiua-12464	117	24	.	.	PUNCT
aiua-12464	118	1	since	since	SCONJ
aiua-12464	118	2	the	the	DET
aiua-12464	118	3	last	last	ADJ
aiua-12464	118	4	two	two	NUM
aiua-12464	118	5	decades	decade	NOUN
aiua-12464	118	6	,	,	PUNCT
aiua-12464	118	7	growing	grow	VERB
aiua-12464	118	8	evidence	evidence	NOUN
aiua-12464	118	9	has	have	AUX
aiua-12464	118	10	revealed	reveal	VERB
aiua-12464	118	11	a	a	DET
aiua-12464	118	12	multifaceted	multifaceted	ADJ
aiua-12464	118	13	function	function	NOUN
aiua-12464	118	14	of	of	ADP
aiua-12464	118	15	cftr	cftr	NOUN
aiua-12464	118	16	in	in	ADP
aiua-12464	118	17	controlling	control	VERB
aiua-12464	118	18	a	a	DET
aiua-12464	118	19	number	number	NOUN
aiua-12464	118	20	of	of	ADP
aiua-12464	118	21	physiological	physiological	ADJ
aiua-12464	118	22	processes	process	NOUN
aiua-12464	118	23	associated	associate	VERB
aiua-12464	118	24	with	with	ADP
aiua-12464	118	25	male	male	ADJ
aiua-12464	118	26	infertility	infertility	NOUN
aiua-12464	118	27	.	.	PUNCT
aiua-12464	119	1	besides	besides	SCONJ
aiua-12464	119	2	its	its	PRON
aiua-12464	119	3	familiar	familiar	ADJ
aiua-12464	119	4	role	role	NOUN
aiua-12464	119	5	of	of	ADP
aiua-12464	119	6	regulating	regulate	VERB
aiua-12464	119	7	electrolytes	electrolyte	NOUN
aiua-12464	119	8	and	and	CCONJ
aiua-12464	119	9	fluid	fluid	ADJ
aiua-12464	119	10	concentration	concentration	NOUN
aiua-12464	119	11	of	of	ADP
aiua-12464	119	12	the	the	DET
aiua-12464	119	13	male	male	ADJ
aiua-12464	119	14	reproductive	reproductive	ADJ
aiua-12464	119	15	duct	duct	NOUN
aiua-12464	119	16	,	,	PUNCT
aiua-12464	119	17	recent	recent	ADJ
aiua-12464	119	18	investigations	investigation	NOUN
aiua-12464	119	19	have	have	AUX
aiua-12464	119	20	indicated	indicate	VERB
aiua-12464	119	21	its	its	PRON
aiua-12464	119	22	participation	participation	NOUN
aiua-12464	119	23	in	in	ADP
aiua-12464	119	24	previously	previously	ADV
aiua-12464	119	25	uncertain	uncertain	ADJ
aiua-12464	119	26	processes	process	NOUN
aiua-12464	119	27	,	,	PUNCT
aiua-12464	119	28	such	such	ADJ
aiua-12464	119	29	as	as	ADP
aiua-12464	119	30	sperm	sperm	NOUN
aiua-12464	119	31	capacitation	capacitation	NOUN
aiua-12464	119	32	and	and	CCONJ
aiua-12464	119	33	spermatogenesis	spermatogenesis	NOUN
aiua-12464	119	34	(	(	PUNCT
aiua-12464	119	35	26	26	NUM
aiua-12464	119	36	,	,	PUNCT
aiua-12464	119	37	27	27	NUM
aiua-12464	119	38	)	)	PUNCT
aiua-12464	119	39	,	,	PUNCT
aiua-12464	119	40	unfolding	unfold	VERB
aiua-12464	119	41	further	further	ADJ
aiua-12464	119	42	potential	potential	ADJ
aiua-12464	119	43	reasons	reason	NOUN
aiua-12464	119	44	associated	associate	VERB
aiua-12464	119	45	with	with	ADP
aiua-12464	119	46	male	male	ADJ
aiua-12464	119	47	infertility	infertility	NOUN
aiua-12464	119	48	,	,	PUNCT
aiua-12464	119	49	and	and	CCONJ
aiua-12464	119	50	strengthening	strengthen	VERB
aiua-12464	119	51	the	the	DET
aiua-12464	119	52	relation	relation	NOUN
aiua-12464	119	53	of	of	ADP
aiua-12464	119	54	cftr	cftr	NOUN
aiua-12464	119	55	mutations	mutation	NOUN
aiua-12464	119	56	with	with	ADP
aiua-12464	119	57	cbvad	cbvad	NOUN
aiua-12464	119	58	.	.	PUNCT
aiua-12464	120	1	as	as	SCONJ
aiua-12464	120	2	new	new	ADJ
aiua-12464	120	3	forms	form	NOUN
aiua-12464	120	4	of	of	ADP
aiua-12464	120	5	infertility	infertility	NOUN
aiua-12464	120	6	in	in	ADP
aiua-12464	120	7	men	man	NOUN
aiua-12464	120	8	are	be	AUX
aiua-12464	120	9	identified	identify	VERB
aiua-12464	120	10	and	and	CCONJ
aiua-12464	120	11	linked	link	VERB
aiua-12464	120	12	with	with	ADP
aiua-12464	120	13	cftr	cftr	NOUN
aiua-12464	120	14	defects	defect	NOUN
aiua-12464	120	15	and	and	CCONJ
aiua-12464	120	16	polymorphisms	polymorphism	NOUN
aiua-12464	120	17	,	,	PUNCT
aiua-12464	120	18	it	it	PRON
aiua-12464	120	19	would	would	AUX
aiua-12464	120	20	n’t	not	PART
aiua-12464	120	21	be	be	AUX
aiua-12464	120	22	entirely	entirely	ADV
aiua-12464	120	23	illogical	illogical	ADJ
aiua-12464	120	24	to	to	PART
aiua-12464	120	25	consider	consider	VERB
aiua-12464	120	26	cftr	cftr	NOUN
aiua-12464	120	27	as	as	ADP
aiua-12464	120	28	the	the	DET
aiua-12464	120	29	molecular	molecular	ADJ
aiua-12464	120	30	marker	marker	NOUN
aiua-12464	120	31	of	of	ADP
aiua-12464	120	32	male	male	ADJ
aiua-12464	120	33	infertility	infertility	NOUN
aiua-12464	120	34	.	.	PUNCT
aiua-12464	121	1	based	base	VERB
aiua-12464	121	2	on	on	ADP
aiua-12464	121	3	strong	strong	ADJ
aiua-12464	121	4	correlation	correlation	NOUN
aiua-12464	121	5	between	between	ADP
aiua-12464	121	6	the	the	DET
aiua-12464	121	7	quality	quality	NOUN
aiua-12464	121	8	of	of	ADP
aiua-12464	121	9	sperm	sperm	NOUN
aiua-12464	121	10	and	and	CCONJ
aiua-12464	121	11	cftr	cftr	NOUN
aiua-12464	121	12	mutations	mutation	NOUN
aiua-12464	121	13	,	,	PUNCT
aiua-12464	121	14	a	a	DET
aiua-12464	121	15	screening	screening	NOUN
aiua-12464	121	16	of	of	ADP
aiua-12464	121	17	cftr	cftr	PROPN
aiua-12464	121	18	gene	gene	NOUN
aiua-12464	121	19	for	for	ADP
aiua-12464	121	20	mutations	mutation	NOUN
aiua-12464	121	21	in	in	ADP
aiua-12464	121	22	obstructive	obstructive	ADJ
aiua-12464	121	23	,	,	PUNCT
aiua-12464	121	24	azoospermia	azoospermia	NOUN
aiua-12464	121	25	and	and	CCONJ
aiua-12464	121	26	non	non	ADJ
aiua-12464	121	27	-	-	ADJ
aiua-12464	121	28	obstructive	obstructive	ADJ
aiua-12464	121	29	individuals	individual	NOUN
aiua-12464	121	30	is	be	AUX
aiua-12464	121	31	suggested	suggest	VERB
aiua-12464	121	32	before	before	SCONJ
aiua-12464	121	33	they	they	PRON
aiua-12464	121	34	opt	opt	VERB
aiua-12464	121	35	for	for	ADP
aiua-12464	121	36	intracytoplasmic	intracytoplasmic	ADJ
aiua-12464	121	37	sperm	sperm	NOUN
aiua-12464	121	38	injection	injection	NOUN
aiua-12464	121	39	due	due	ADP
aiua-12464	121	40	to	to	ADP
aiua-12464	121	41	strong	strong	ADJ
aiua-12464	121	42	link	link	NOUN
aiua-12464	121	43	-	-	PUNCT
aiua-12464	121	44	up	up	NOUN
aiua-12464	121	45	between	between	ADP
aiua-12464	121	46	sperm	sperm	NOUN
aiua-12464	121	47	quality	quality	NOUN
aiua-12464	121	48	and	and	CCONJ
aiua-12464	121	49	cftr	cftr	NOUN
aiua-12464	121	50	mutations	mutation	NOUN
aiua-12464	121	51	(	(	PUNCT
aiua-12464	121	52	18	18	NUM
aiua-12464	121	53	)	)	PUNCT
aiua-12464	121	54	.	.	PUNCT
aiua-12464	122	1	common	common	ADJ
aiua-12464	122	2	mutation	mutation	NOUN
aiua-12464	122	3	panels	panel	NOUN
aiua-12464	122	4	used	use	VERB
aiua-12464	122	5	for	for	ADP
aiua-12464	122	6	mutation	mutation	NOUN
aiua-12464	122	7	analysis	analysis	NOUN
aiua-12464	122	8	of	of	ADP
aiua-12464	122	9	males	male	NOUN
aiua-12464	122	10	with	with	ADP
aiua-12464	122	11	obstructive	obstructive	ADJ
aiua-12464	122	12	azoospermia	azoospermia	NOUN
aiua-12464	122	13	and	and	CCONJ
aiua-12464	122	14	cbavd	cbavd	NOUN
aiua-12464	122	15	are	be	AUX
aiua-12464	122	16	unable	unable	ADJ
aiua-12464	122	17	to	to	PART
aiua-12464	122	18	identify	identify	VERB
aiua-12464	122	19	cftr	cftr	NOUN
aiua-12464	122	20	mutation	mutation	NOUN
aiua-12464	122	21	variants	variant	NOUN
aiua-12464	122	22	in	in	ADP
aiua-12464	122	23	a	a	DET
aiua-12464	122	24	given	give	VERB
aiua-12464	122	25	population	population	NOUN
aiua-12464	122	26	.	.	PUNCT
aiua-12464	123	1	initially	initially	ADV
aiua-12464	123	2	,	,	PUNCT
aiua-12464	123	3	the	the	DET
aiua-12464	123	4	mutation	mutation	NOUN
aiua-12464	123	5	panel	panel	NOUN
aiua-12464	123	6	was	be	AUX
aiua-12464	123	7	designed	design	VERB
aiua-12464	123	8	to	to	PART
aiua-12464	123	9	detect	detect	VERB
aiua-12464	123	10	the	the	DET
aiua-12464	123	11	most	most	ADV
aiua-12464	123	12	frequent	frequent	ADJ
aiua-12464	123	13	cf	cf	NOUN
aiua-12464	123	14	causing	cause	VERB
aiua-12464	123	15	mutations	mutation	NOUN
aiua-12464	123	16	in	in	ADP
aiua-12464	123	17	the	the	DET
aiua-12464	123	18	affected	affected	ADJ
aiua-12464	123	19	individuals	individual	NOUN
aiua-12464	123	20	of	of	ADP
aiua-12464	123	21	north	north	ADJ
aiua-12464	123	22	european	european	ADJ
aiua-12464	123	23	caucasians	caucasian	NOUN
aiua-12464	123	24	(	(	PUNCT
aiua-12464	123	25	19	19	NUM
aiua-12464	123	26	)	)	PUNCT
aiua-12464	123	27	.	.	PUNCT
aiua-12464	124	1	on	on	ADP
aiua-12464	124	2	the	the	DET
aiua-12464	124	3	contrary	contrary	NOUN
aiua-12464	124	4	,	,	PUNCT
aiua-12464	124	5	the	the	DET
aiua-12464	124	6	genetic	genetic	ADJ
aiua-12464	124	7	spectrum	spectrum	NOUN
aiua-12464	124	8	of	of	ADP
aiua-12464	124	9	south	south	ADJ
aiua-12464	124	10	asian	asian	ADJ
aiua-12464	124	11	people	people	NOUN
aiua-12464	124	12	reported	report	VERB
aiua-12464	124	13	increased	increase	VERB
aiua-12464	124	14	prevalence	prevalence	NOUN
aiua-12464	124	15	of	of	ADP
aiua-12464	124	16	novel	novel	ADJ
aiua-12464	124	17	mutation	mutation	NOUN
aiua-12464	124	18	such	such	ADJ
aiua-12464	124	19	as	as	ADP
aiua-12464	124	20	f508	f508	PROPN
aiua-12464	124	21	which	which	PRON
aiua-12464	124	22	comprises	comprise	VERB
aiua-12464	124	23	40	40	NUM
aiua-12464	124	24	-	-	SYM
aiua-12464	124	25	50	50	NUM
aiua-12464	124	26	%	%	NOUN
aiua-12464	124	27	of	of	ADP
aiua-12464	124	28	cases	case	NOUN
aiua-12464	124	29	as	as	ADP
aiua-12464	124	30	compared	compare	VERB
aiua-12464	124	31	to	to	ADP
aiua-12464	124	32	66	66	NUM
aiua-12464	124	33	%	%	NOUN
aiua-12464	124	34	reported	report	VERB
aiua-12464	124	35	cf	cf	NOUN
aiua-12464	124	36	cases	case	NOUN
aiua-12464	124	37	worldwide	worldwide	ADV
aiua-12464	124	38	.	.	PUNCT
aiua-12464	125	1	moreover	moreover	ADV
aiua-12464	125	2	,	,	PUNCT
aiua-12464	125	3	in	in	ADP
aiua-12464	125	4	south	south	PROPN
aiua-12464	125	5	asians	asians	PROPN
aiua-12464	125	6	frequency	frequency	NOUN
aiua-12464	125	7	of	of	ADP
aiua-12464	125	8	mutation	mutation	NOUN
aiua-12464	125	9	detection	detection	NOUN
aiua-12464	125	10	is	be	AUX
aiua-12464	125	11	lower	low	ADJ
aiua-12464	125	12	than	than	ADP
aiua-12464	125	13	the	the	DET
aiua-12464	125	14	caucasians	caucasian	NOUN
aiua-12464	125	15	i.e.	i.e.	X
aiua-12464	125	16	,	,	PUNCT
aiua-12464	125	17	50	50	NUM
aiua-12464	125	18	%	%	NOUN
aiua-12464	125	19	and	and	CCONJ
aiua-12464	125	20	77	77	NUM
aiua-12464	125	21	%	%	NOUN
aiua-12464	125	22	respectively	respectively	ADV
aiua-12464	125	23	.	.	PUNCT
aiua-12464	126	1	also	also	ADV
aiua-12464	126	2	,	,	PUNCT
aiua-12464	126	3	in	in	ADP
aiua-12464	126	4	several	several	ADJ
aiua-12464	126	5	cases	case	NOUN
aiua-12464	126	6	of	of	ADP
aiua-12464	126	7	cf	cf	NOUN
aiua-12464	126	8	,	,	PUNCT
aiua-12464	126	9	mutations	mutation	NOUN
aiua-12464	126	10	remained	remain	VERB
aiua-12464	126	11	undetected	undetected	ADJ
aiua-12464	126	12	(	(	PUNCT
aiua-12464	126	13	23	23	NUM
aiua-12464	126	14	)	)	PUNCT
aiua-12464	126	15	.	.	PUNCT
aiua-12464	127	1	in	in	ADP
aiua-12464	127	2	our	our	PRON
aiua-12464	127	3	study	study	NOUN
aiua-12464	127	4	,	,	PUNCT
aiua-12464	127	5	screening	screen	VERB
aiua-12464	127	6	of	of	ADP
aiua-12464	127	7	cftr	cftr	PROPN
aiua-12464	127	8	promoter	promoter	NOUN
aiua-12464	127	9	region	region	NOUN
aiua-12464	127	10	and	and	CCONJ
aiua-12464	127	11	exon	exon	NOUN
aiua-12464	127	12	10	10	NUM
aiua-12464	127	13	was	be	AUX
aiua-12464	127	14	achieved	achieve	VERB
aiua-12464	127	15	by	by	ADP
aiua-12464	127	16	the	the	DET
aiua-12464	127	17	dna	dna	PROPN
aiua-12464	127	18	sequence	sequence	NOUN
aiua-12464	127	19	method	method	NOUN
aiua-12464	127	20	in	in	ADP
aiua-12464	127	21	cbavd	cbavd	ADJ
aiua-12464	127	22	patients	patient	NOUN
aiua-12464	127	23	.	.	PUNCT
aiua-12464	128	1	we	we	PRON
aiua-12464	128	2	have	have	AUX
aiua-12464	128	3	identified	identify	VERB
aiua-12464	128	4	one	one	NUM
aiua-12464	128	5	or	or	CCONJ
aiua-12464	128	6	two	two	NUM
aiua-12464	128	7	mutations	mutation	NOUN
aiua-12464	128	8	in	in	ADP
aiua-12464	128	9	35	35	NUM
aiua-12464	128	10	%	%	NOUN
aiua-12464	128	11	of	of	ADP
aiua-12464	128	12	our	our	PRON
aiua-12464	128	13	sample	sample	NOUN
aiua-12464	128	14	patients	patient	NOUN
aiua-12464	128	15	.	.	PUNCT
aiua-12464	129	1	discovering	discover	VERB
aiua-12464	129	2	the	the	DET
aiua-12464	129	3	presence	presence	NOUN
aiua-12464	129	4	of	of	ADP
aiua-12464	129	5	v456a	v456a	PROPN
aiua-12464	129	6	in	in	ADP
aiua-12464	129	7	4	4	NUM
aiua-12464	129	8	of	of	ADP
aiua-12464	129	9	17	17	NUM
aiua-12464	129	10	patients	patient	NOUN
aiua-12464	129	11	further	far	ADV
aiua-12464	129	12	adds	add	VERB
aiua-12464	129	13	evidence	evidence	NOUN
aiua-12464	129	14	for	for	ADP
aiua-12464	129	15	its	its	PRON
aiua-12464	129	16	pathogenic	pathogenic	ADJ
aiua-12464	129	17	nature	nature	NOUN
aiua-12464	129	18	and	and	CCONJ
aiua-12464	129	19	supports	support	VERB
aiua-12464	129	20	its	its	PRON
aiua-12464	129	21	inclusion	inclusion	NOUN
aiua-12464	129	22	in	in	ADP
aiua-12464	129	23	the	the	DET
aiua-12464	129	24	genetic	genetic	ADJ
aiua-12464	129	25	diagnostic	diagnostic	NOUN
aiua-12464	129	26	of	of	ADP
aiua-12464	129	27	cbavd	cbavd	NOUN
aiua-12464	129	28	,	,	PUNCT
aiua-12464	129	29	especially	especially	ADV
aiua-12464	129	30	in	in	ADP
aiua-12464	129	31	the	the	DET
aiua-12464	129	32	south	south	ADJ
aiua-12464	129	33	asian	asian	ADJ
aiua-12464	129	34	population	population	NOUN
aiua-12464	129	35	.	.	PUNCT
aiua-12464	130	1	v456a	v456a	PROPN
aiua-12464	130	2	was	be	AUX
aiua-12464	130	3	initially	initially	ADV
aiua-12464	130	4	described	describe	VERB
aiua-12464	130	5	as	as	ADP
aiua-12464	130	6	polymorphism	polymorphism	NOUN
aiua-12464	130	7	(	(	PUNCT
aiua-12464	130	8	28	28	NUM
aiua-12464	130	9	)	)	PUNCT
aiua-12464	130	10	,	,	PUNCT
aiua-12464	130	11	but	but	CCONJ
aiua-12464	130	12	with	with	ADP
aiua-12464	130	13	further	further	ADJ
aiua-12464	130	14	investigation	investigation	NOUN
aiua-12464	130	15	the	the	DET
aiua-12464	130	16	mutation	mutation	NOUN
aiua-12464	130	17	was	be	AUX
aiua-12464	130	18	labeled	label	VERB
aiua-12464	130	19	as	as	ADP
aiua-12464	130	20	a	a	DET
aiua-12464	130	21	mild	mild	ADJ
aiua-12464	130	22	disease	disease	NOUN
aiua-12464	130	23	-	-	PUNCT
aiua-12464	130	24	causing	cause	VERB
aiua-12464	130	25	mutation	mutation	NOUN
aiua-12464	130	26	particularly	particularly	ADV
aiua-12464	130	27	in	in	ADP
aiua-12464	130	28	adults	adult	NOUN
aiua-12464	130	29	with	with	ADP
aiua-12464	130	30	bronchiectasis	bronchiectasis	NOUN
aiua-12464	130	31	,	,	PUNCT
aiua-12464	130	32	while	while	SCONJ
aiua-12464	130	33	it	it	PRON
aiua-12464	130	34	also	also	ADV
aiua-12464	130	35	paired	pair	VERB
aiua-12464	130	36	up	up	ADP
aiua-12464	130	37	with	with	ADP
aiua-12464	130	38	more	more	ADV
aiua-12464	130	39	prominent	prominent	ADJ
aiua-12464	130	40	mutations	mutation	NOUN
aiua-12464	130	41	(	(	PUNCT
aiua-12464	130	42	f508	f508	NUM
aiua-12464	130	43	)	)	PUNCT
aiua-12464	130	44	(	(	PUNCT
aiua-12464	130	45	29	29	NUM
aiua-12464	130	46	)	)	PUNCT
aiua-12464	130	47	.	.	PUNCT
aiua-12464	131	1	previously	previously	ADV
aiua-12464	131	2	,	,	PUNCT
aiua-12464	131	3	it	it	PRON
aiua-12464	131	4	has	have	AUX
aiua-12464	131	5	been	be	AUX
aiua-12464	131	6	linked	link	VERB
aiua-12464	131	7	with	with	ADP
aiua-12464	131	8	cbavd	cbavd	NOUN
aiua-12464	131	9	as	as	ADV
aiua-12464	131	10	well	well	ADV
aiua-12464	131	11	(	(	PUNCT
aiua-12464	131	12	28	28	NUM
aiua-12464	131	13	)	)	PUNCT
aiua-12464	131	14	.	.	PUNCT
aiua-12464	132	1	regardless	regardless	ADV
aiua-12464	132	2	,	,	PUNCT
aiua-12464	132	3	it	it	PRON
aiua-12464	132	4	is	be	AUX
aiua-12464	132	5	a	a	DET
aiua-12464	132	6	rare	rare	ADJ
aiua-12464	132	7	mutation	mutation	NOUN
aiua-12464	132	8	occurring	occur	VERB
aiua-12464	132	9	only	only	ADV
aiua-12464	132	10	in	in	ADP
aiua-12464	132	11	2.4	2.4	NUM
aiua-12464	132	12	%	%	NOUN
aiua-12464	132	13	of	of	ADP
aiua-12464	132	14	78	78	NUM
aiua-12464	132	15	south	south	ADJ
aiua-12464	132	16	asian	asian	ADJ
aiua-12464	132	17	patients	patient	NOUN
aiua-12464	132	18	(	(	PUNCT
aiua-12464	132	19	30	30	NUM
aiua-12464	132	20	)	)	PUNCT
aiua-12464	132	21	.	.	PUNCT
aiua-12464	133	1	danziger	danziger	PROPN
aiua-12464	133	2	et	et	PROPN
aiua-12464	133	3	al	al	PROPN
aiua-12464	133	4	.	.	PROPN
aiua-12464	133	5	,	,	PUNCT
aiua-12464	133	6	and	and	CCONJ
aiua-12464	133	7	clinical	clinical	ADJ
aiua-12464	133	8	evidence	evidence	NOUN
aiua-12464	133	9	from	from	ADP
aiua-12464	133	10	uppaluri	uppaluri	PROPN
aiua-12464	133	11	et	et	PROPN
aiua-12464	133	12	al	al	PROPN
aiua-12464	133	13	.	.	PROPN
aiua-12464	133	14	,	,	PUNCT
aiua-12464	133	15	suggested	suggest	VERB
aiua-12464	133	16	that	that	SCONJ
aiua-12464	133	17	v456a	v456a	PROPN
aiua-12464	133	18	holds	hold	VERB
aiua-12464	133	19	importance	importance	NOUN
aiua-12464	133	20	as	as	ADP
aiua-12464	133	21	a	a	DET
aiua-12464	133	22	disease	disease	NOUN
aiua-12464	133	23	-	-	PUNCT
aiua-12464	133	24	causing	cause	VERB
aiua-12464	133	25	mutation	mutation	NOUN
aiua-12464	133	26	and	and	CCONJ
aiua-12464	133	27	is	be	AUX
aiua-12464	133	28	not	not	PART
aiua-12464	133	29	merely	merely	ADV
aiua-12464	133	30	a	a	DET
aiua-12464	133	31	mild	mild	ADJ
aiua-12464	133	32	polymorphism	polymorphism	NOUN
aiua-12464	133	33	(	(	PUNCT
aiua-12464	133	34	31	31	NUM
aiua-12464	133	35	)	)	PUNCT
aiua-12464	133	36	.	.	PUNCT
aiua-12464	134	1	exon	exon	PROPN
aiua-12464	134	2	10	10	NUM
aiua-12464	134	3	of	of	ADP
aiua-12464	134	4	the	the	DET
aiua-12464	134	5	cftr	cftr	NOUN
aiua-12464	134	6	gene	gene	NOUN
aiua-12464	134	7	codes	code	VERB
aiua-12464	134	8	a	a	DET
aiua-12464	134	9	portion	portion	NOUN
aiua-12464	134	10	of	of	ADP
aiua-12464	134	11	the	the	DET
aiua-12464	134	12	nucleotide	nucleotide	NOUN
aiua-12464	134	13	-	-	PUNCT
aiua-12464	134	14	binding	bind	VERB
aiua-12464	134	15	domain	domain	NOUN
aiua-12464	134	16	(	(	PUNCT
aiua-12464	134	17	nbd	nbd	PROPN
aiua-12464	134	18	i	i	PROPN
aiua-12464	134	19	and	and	CCONJ
aiua-12464	134	20	ii	ii	NOUN
aiua-12464	134	21	)	)	PUNCT
aiua-12464	134	22	in	in	ADP
aiua-12464	134	23	cftr	cftr	PROPN
aiua-12464	134	24	protein	protein	NOUN
aiua-12464	134	25	.	.	PUNCT
aiua-12464	135	1	nbd	nbd	PROPN
aiua-12464	135	2	plays	play	VERB
aiua-12464	135	3	a	a	DET
aiua-12464	135	4	crucial	crucial	ADJ
aiua-12464	135	5	role	role	NOUN
aiua-12464	135	6	in	in	ADP
aiua-12464	135	7	the	the	DET
aiua-12464	135	8	regulation	regulation	NOUN
aiua-12464	135	9	of	of	ADP
aiua-12464	135	10	cftr	cftr	NOUN
aiua-12464	135	11	function	function	NOUN
aiua-12464	135	12	.	.	PUNCT
aiua-12464	136	1	it	it	PRON
aiua-12464	136	2	is	be	AUX
aiua-12464	136	3	involved	involve	VERB
aiua-12464	136	4	in	in	ADP
aiua-12464	136	5	atp	atp	PROPN
aiua-12464	136	6	(	(	PUNCT
aiua-12464	136	7	adenosine	adenosine	ADJ
aiua-12464	136	8	triphosphate	triphosphate	NOUN
aiua-12464	136	9	)	)	PUNCT
aiua-12464	136	10	binding	binding	NOUN
aiua-12464	136	11	and	and	CCONJ
aiua-12464	136	12	hydrolysis	hydrolysis	NOUN
aiua-12464	136	13	,	,	PUNCT
aiua-12464	136	14	which	which	PRON
aiua-12464	136	15	is	be	AUX
aiua-12464	136	16	necessary	necessary	ADJ
aiua-12464	136	17	for	for	ADP
aiua-12464	136	18	the	the	DET
aiua-12464	136	19	opening	opening	NOUN
aiua-12464	136	20	and	and	CCONJ
aiua-12464	136	21	closing	closing	NOUN
aiua-12464	136	22	of	of	ADP
aiua-12464	136	23	the	the	DET
aiua-12464	136	24	chloride	chloride	NOUN
aiua-12464	136	25	channel	channel	NOUN
aiua-12464	136	26	formed	form	VERB
aiua-12464	136	27	by	by	ADP
aiua-12464	136	28	cftr	cftr	PROPN
aiua-12464	136	29	.	.	PUNCT
aiua-12464	137	1	atp	atp	PROPN
aiua-12464	137	2	binding	bind	VERB
aiua-12464	137	3	to	to	ADP
aiua-12464	137	4	nbd	nbd	PROPN
aiua-12464	137	5	triggers	trigger	VERB
aiua-12464	137	6	conformational	conformational	ADJ
aiua-12464	137	7	changes	change	NOUN
aiua-12464	137	8	that	that	PRON
aiua-12464	137	9	enable	enable	VERB
aiua-12464	137	10	the	the	DET
aiua-12464	137	11	channel	channel	NOUN
aiua-12464	137	12	to	to	PART
aiua-12464	137	13	transport	transport	VERB
aiua-12464	137	14	chloride	chloride	NOUN
aiua-12464	137	15	ions	ion	NOUN
aiua-12464	137	16	across	across	ADP
aiua-12464	137	17	the	the	DET
aiua-12464	137	18	cell	cell	NOUN
aiua-12464	137	19	membrane	membrane	NOUN
aiua-12464	137	20	.	.	PUNCT
aiua-12464	138	1	mutations	mutation	NOUN
aiua-12464	138	2	in	in	ADP
aiua-12464	138	3	exon	exon	NOUN
aiua-12464	138	4	10	10	NUM
aiua-12464	138	5	can	can	AUX
aiua-12464	138	6	disrupt	disrupt	VERB
aiua-12464	138	7	the	the	DET
aiua-12464	138	8	structure	structure	NOUN
aiua-12464	138	9	and	and	CCONJ
aiua-12464	138	10	function	function	NOUN
aiua-12464	138	11	of	of	ADP
aiua-12464	138	12	nbd	nbd	PROPN
aiua-12464	138	13	(	(	PUNCT
aiua-12464	138	14	i	i	PROPN
aiua-12464	138	15	or	or	CCONJ
aiua-12464	138	16	ii	ii	NUM
aiua-12464	138	17	)	)	PUNCT
aiua-12464	138	18	;	;	PUNCT
aiua-12464	138	19	impairing	impair	VERB
aiua-12464	138	20	atp	atp	NOUN
aiua-12464	138	21	binding	bind	VERB
aiua-12464	138	22	,	,	PUNCT
aiua-12464	138	23	hydrolysis	hydrolysis	NOUN
aiua-12464	138	24	,	,	PUNCT
aiua-12464	138	25	and	and	CCONJ
aiua-12464	138	26	overall	overall	ADJ
aiua-12464	138	27	cftr	cftr	PROPN
aiua-12464	138	28	channel	channel	NOUN
aiua-12464	138	29	activity	activity	NOUN
aiua-12464	138	30	.	.	PUNCT
aiua-12464	139	1	the	the	DET
aiua-12464	139	2	impaired	impaired	ADJ
aiua-12464	139	3	atp	atp	NOUN
aiua-12464	139	4	binding	binding	NOUN
aiua-12464	139	5	reduces	reduce	VERB
aiua-12464	139	6	the	the	DET
aiua-12464	139	7	ability	ability	NOUN
aiua-12464	139	8	of	of	ADP
aiua-12464	139	9	cftr	cftr	NOUN
aiua-12464	139	10	to	to	PART
aiua-12464	139	11	properly	properly	ADV
aiua-12464	139	12	respond	respond	VERB
aiua-12464	139	13	to	to	ADP
aiua-12464	139	14	cellular	cellular	ADJ
aiua-12464	139	15	signals	signal	NOUN
aiua-12464	139	16	and	and	CCONJ
aiua-12464	139	17	regulate	regulate	VERB
aiua-12464	139	18	chloride	chloride	NOUN
aiua-12464	139	19	ion	ion	NOUN
aiua-12464	139	20	transport	transport	NOUN
aiua-12464	139	21	,	,	PUNCT
aiua-12464	139	22	contributing	contribute	VERB
aiua-12464	139	23	to	to	ADP
aiua-12464	139	24	the	the	DET
aiua-12464	139	25	dysfunction	dysfunction	NOUN
aiua-12464	139	26	observed	observe	VERB
aiua-12464	139	27	in	in	ADP
aiua-12464	139	28	cystic	cystic	ADJ
aiua-12464	139	29	fibrosis	fibrosis	NOUN
aiua-12464	139	30	.	.	PUNCT
aiua-12464	140	1	mutations	mutation	NOUN
aiua-12464	140	2	can	can	AUX
aiua-12464	140	3	also	also	ADV
aiua-12464	140	4	affect	affect	VERB
aiua-12464	140	5	atp	atp	NOUN
aiua-12464	140	6	hydrolysis	hydrolysis	NOUN
aiua-12464	140	7	,	,	PUNCT
aiua-12464	140	8	which	which	PRON
aiua-12464	140	9	is	be	AUX
aiua-12464	140	10	necessary	necessary	ADJ
aiua-12464	140	11	for	for	ADP
aiua-12464	140	12	channel	channel	NOUN
aiua-12464	140	13	gating	gating	NOUN
aiua-12464	140	14	.	.	PUNCT
aiua-12464	141	1	the	the	DET
aiua-12464	141	2	specific	specific	ADJ
aiua-12464	141	3	impact	impact	NOUN
aiua-12464	141	4	of	of	ADP
aiua-12464	141	5	mutations	mutation	NOUN
aiua-12464	141	6	in	in	ADP
aiua-12464	141	7	exon	exon	NOUN
aiua-12464	141	8	10	10	NUM
aiua-12464	141	9	can	can	AUX
aiua-12464	141	10	vary	vary	VERB
aiua-12464	141	11	depending	depend	VERB
aiua-12464	141	12	on	on	ADP
aiua-12464	141	13	the	the	DET
aiua-12464	141	14	nature	nature	NOUN
aiua-12464	141	15	and	and	CCONJ
aiua-12464	141	16	location	location	NOUN
aiua-12464	141	17	of	of	ADP
aiua-12464	141	18	the	the	DET
aiua-12464	141	19	mutation	mutation	NOUN
aiua-12464	141	20	within	within	ADP
aiua-12464	141	21	the	the	DET
aiua-12464	141	22	exon	exon	NOUN
aiua-12464	141	23	(	(	PUNCT
aiua-12464	141	24	1	1	NUM
aiua-12464	141	25	)	)	PUNCT
aiua-12464	141	26	.	.	PUNCT
aiua-12464	142	1	based	base	VERB
aiua-12464	142	2	on	on	ADP
aiua-12464	142	3	literature	literature	NOUN
aiua-12464	142	4	,	,	PUNCT
aiua-12464	142	5	the	the	DET
aiua-12464	142	6	overlapping	overlap	VERB
aiua-12464	142	7	function	function	NOUN
aiua-12464	142	8	of	of	ADP
aiua-12464	142	9	nbd1	nbd1	PROPN
aiua-12464	142	10	and	and	CCONJ
aiua-12464	142	11	nbd2	nbd2	NOUN
aiua-12464	142	12	domain	domain	NOUN
aiua-12464	142	13	and	and	CCONJ
aiua-12464	142	14	the	the	DET
aiua-12464	142	15	relation	relation	NOUN
aiua-12464	142	16	of	of	ADP
aiua-12464	142	17	exon	exon	NOUN
aiua-12464	142	18	10	10	NUM
aiua-12464	142	19	in	in	ADP
aiua-12464	142	20	the	the	DET
aiua-12464	142	21	proper	proper	ADJ
aiua-12464	142	22	functioning	functioning	NOUN
aiua-12464	142	23	of	of	ADP
aiua-12464	142	24	nbd	nbd	PROPN
aiua-12464	142	25	domain	domain	NOUN
aiua-12464	142	26	(	(	PUNCT
aiua-12464	142	27	32	32	NUM
aiua-12464	142	28	,	,	PUNCT
aiua-12464	142	29	33	33	NUM
aiua-12464	142	30	)	)	PUNCT
aiua-12464	142	31	hints	hint	NOUN
aiua-12464	142	32	towards	towards	ADP
aiua-12464	142	33	a	a	DET
aiua-12464	142	34	relation	relation	NOUN
aiua-12464	142	35	between	between	ADP
aiua-12464	142	36	the	the	DET
aiua-12464	142	37	nbd	nbd	PROPN
aiua-12464	142	38	domains	domain	NOUN
aiua-12464	142	39	of	of	ADP
aiua-12464	142	40	cftr	cftr	NOUN
aiua-12464	142	41	protein	protein	NOUN
aiua-12464	142	42	and	and	CCONJ
aiua-12464	142	43	the	the	DET
aiua-12464	142	44	mutations	mutation	NOUN
aiua-12464	142	45	observed	observe	VERB
aiua-12464	142	46	in	in	ADP
aiua-12464	142	47	our	our	PRON
aiua-12464	142	48	study	study	NOUN
aiua-12464	142	49	group	group	NOUN
aiua-12464	142	50	;	;	PUNCT
aiua-12464	142	51	k464e	k464e	PROPN
aiua-12464	142	52	,	,	PUNCT
aiua-12464	142	53	a	a	DET
aiua-12464	142	54	missense	missense	NOUN
aiua-12464	142	55	variant	variant	NOUN
aiua-12464	142	56	which	which	PRON
aiua-12464	142	57	is	be	AUX
aiua-12464	142	58	formed	form	VERB
aiua-12464	142	59	as	as	ADP
aiua-12464	142	60	a	a	DET
aiua-12464	142	61	result	result	NOUN
aiua-12464	142	62	of	of	ADP
aiua-12464	142	63	base	base	NOUN
aiua-12464	142	64	substitution	substitution	NOUN
aiua-12464	142	65	of	of	ADP
aiua-12464	142	66	a	a	PRON
aiua-12464	142	67	by	by	ADP
aiua-12464	142	68	g	g	PROPN
aiua-12464	142	69	at	at	ADP
aiua-12464	142	70	nucleotide	nucleotide	ADJ
aiua-12464	142	71	position	position	NOUN
aiua-12464	142	72	181	181	NUM
aiua-12464	142	73	of	of	ADP
aiua-12464	142	74	exon	exon	PROPN
aiua-12464	142	75	10	10	NUM
aiua-12464	142	76	of	of	ADP
aiua-12464	142	77	cftr	cftr	NOUN
aiua-12464	142	78	.	.	PUNCT
aiua-12464	143	1	it	it	PRON
aiua-12464	143	2	can	can	AUX
aiua-12464	143	3	be	be	AUX
aiua-12464	143	4	assumed	assume	VERB
aiua-12464	143	5	that	that	SCONJ
aiua-12464	143	6	this	this	DET
aiua-12464	143	7	mutation	mutation	NOUN
aiua-12464	143	8	could	could	AUX
aiua-12464	143	9	potentially	potentially	ADV
aiua-12464	143	10	affect	affect	VERB
aiua-12464	143	11	the	the	DET
aiua-12464	143	12	nbd	nbd	PROPN
aiua-12464	143	13	domains	domains	PROPN
aiua-12464	143	14	,	,	PUNCT
aiua-12464	143	15	impacting	impact	VERB
aiua-12464	143	16	its	its	PRON
aiua-12464	143	17	ability	ability	NOUN
aiua-12464	143	18	to	to	PART
aiua-12464	143	19	bind	bind	VERB
aiua-12464	143	20	and	and	CCONJ
aiua-12464	143	21	hydrolyze	hydrolyze	VERB
aiua-12464	143	22	atp	atp	NOUN
aiua-12464	143	23	,	,	PUNCT
aiua-12464	143	24	as	as	SCONJ
aiua-12464	143	25	proved	prove	VERB
aiua-12464	143	26	,	,	PUNCT
aiua-12464	143	27	and	and	CCONJ
aiua-12464	143	28	described	describe	VERB
aiua-12464	143	29	by	by	ADP
aiua-12464	143	30	the	the	DET
aiua-12464	143	31	literature	literature	NOUN
aiua-12464	143	32	figure	figure	NOUN
aiua-12464	143	33	3	3	NUM
aiua-12464	143	34	.	.	PUNCT
aiua-12464	143	35	structural	structural	ADJ
aiua-12464	143	36	change	change	NOUN
aiua-12464	143	37	v456a	v456a	PROPN
aiua-12464	143	38	(	(	PUNCT
aiua-12464	143	39	a	a	X
aiua-12464	143	40	)	)	PUNCT
aiua-12464	143	41	and	and	CCONJ
aiua-12464	143	42	k464e	k464e	PROPN
aiua-12464	143	43	(	(	PUNCT
aiua-12464	143	44	b	b	X
aiua-12464	143	45	)	)	PUNCT
aiua-12464	143	46	instanced	instance	VERB
aiua-12464	143	47	by	by	ADP
aiua-12464	143	48	project	project	NOUN
aiua-12464	143	49	hope	hope	NOUN
aiua-12464	143	50	.	.	PUNCT
aiua-12464	144	1	the	the	DET
aiua-12464	144	2	protein	protein	NOUN
aiua-12464	144	3	is	be	AUX
aiua-12464	144	4	colored	color	VERB
aiua-12464	144	5	grey	grey	NOUN
aiua-12464	144	6	,	,	PUNCT
aiua-12464	144	7	the	the	DET
aiua-12464	144	8	side	side	NOUN
aiua-12464	144	9	chains	chain	NOUN
aiua-12464	144	10	of	of	ADP
aiua-12464	144	11	both	both	CCONJ
aiua-12464	144	12	the	the	DET
aiua-12464	144	13	wild	wild	ADJ
aiua-12464	144	14	-	-	PUNCT
aiua-12464	144	15	type	type	NOUN
aiua-12464	144	16	and	and	CCONJ
aiua-12464	144	17	the	the	DET
aiua-12464	144	18	mutant	mutant	ADJ
aiua-12464	144	19	residues	residue	NOUN
aiua-12464	144	20	are	be	AUX
aiua-12464	144	21	indicated	indicate	VERB
aiua-12464	144	22	as	as	ADP
aiua-12464	144	23	green	green	ADJ
aiua-12464	144	24	and	and	CCONJ
aiua-12464	144	25	red	red	ADJ
aiua-12464	144	26	respectively	respectively	ADV
aiua-12464	144	27	,	,	PUNCT
aiua-12464	144	28	ligand	ligand	PROPN
aiua-12464	144	29	represented	represent	VERB
aiua-12464	144	30	as	as	ADP
aiua-12464	144	31	grey	grey	ADJ
aiua-12464	144	32	ball	ball	NOUN
aiua-12464	144	33	structure	structure	NOUN
aiua-12464	144	34	(	(	PUNCT
aiua-12464	144	35	b	b	NOUN
aiua-12464	144	36	)	)	PUNCT
aiua-12464	144	37	.	.	PUNCT
aiua-12464	145	1	archivio	archivio	NOUN
aiua-12464	145	2	italiano	italiano	PROPN
aiua-12464	145	3	di	di	X
aiua-12464	145	4	urologia	urologia	PROPN
aiua-12464	145	5	e	e	PROPN
aiua-12464	145	6	andrologia	andrologia	NOUN
aiua-12464	145	7	2024	2024	NUM
aiua-12464	145	8	;	;	PUNCT
aiua-12464	145	9	96(3):12464	96(3):12464	NUM
aiua-12464	145	10	k.	k.	PROPN
aiua-12464	145	11	bakhat	bakhat	PROPN
aiua-12464	145	12	,	,	PUNCT
aiua-12464	145	13	i.	i.	PROPN
aiua-12464	145	14	mateen	mateen	PROPN
aiua-12464	145	15	,	,	PUNCT
aiua-12464	145	16	h.	h.	PROPN
aiua-12464	145	17	saif	saif	PROPN
aiua-12464	145	18	,	,	PUNCT
aiua-12464	145	19	et	et	PROPN
aiua-12464	145	20	al	al	PROPN
aiua-12464	145	21	.	.	PROPN
aiua-12464	145	22	6	6	NUM
aiua-12464	145	23	for	for	ADP
aiua-12464	145	24	other	other	ADJ
aiua-12464	145	25	exon	exon	ADJ
aiua-12464	145	26	10	10	NUM
aiua-12464	145	27	mutations	mutation	NOUN
aiua-12464	145	28	.	.	PUNCT
aiua-12464	146	1	the	the	DET
aiua-12464	146	2	k464e	k464e	PROPN
aiua-12464	146	3	mutation	mutation	NOUN
aiua-12464	146	4	also	also	ADV
aiua-12464	146	5	implicates	implicate	VERB
aiua-12464	146	6	to	to	PART
aiua-12464	146	7	be	be	AUX
aiua-12464	146	8	defective	defective	ADJ
aiua-12464	146	9	for	for	ADP
aiua-12464	146	10	translational	translational	ADJ
aiua-12464	146	11	protein	protein	NOUN
aiua-12464	146	12	insertions	insertion	NOUN
aiua-12464	146	13	on	on	ADP
aiua-12464	146	14	the	the	DET
aiua-12464	146	15	membrane	membrane	NOUN
aiua-12464	146	16	gated	gate	VERB
aiua-12464	146	17	channels	channel	NOUN
aiua-12464	146	18	and	and	CCONJ
aiua-12464	146	19	ribosome	ribosome	NOUN
aiua-12464	146	20	binding	bind	VERB
aiua-12464	146	21	(	(	PUNCT
aiua-12464	146	22	34	34	NUM
aiua-12464	146	23	)	)	PUNCT
aiua-12464	146	24	,	,	PUNCT
aiua-12464	146	25	whereas	whereas	SCONJ
aiua-12464	146	26	the	the	DET
aiua-12464	146	27	v456a	v456a	PROPN
aiua-12464	146	28	mutation	mutation	NOUN
aiua-12464	146	29	found	find	VERB
aiua-12464	146	30	in	in	ADP
aiua-12464	146	31	four	four	NUM
aiua-12464	146	32	of	of	ADP
aiua-12464	146	33	our	our	PRON
aiua-12464	146	34	cbavd	cbavd	NOUN
aiua-12464	146	35	patients	patient	NOUN
aiua-12464	146	36	(	(	PUNCT
aiua-12464	146	37	hwp3	hwp3	PROPN
aiua-12464	146	38	,	,	PUNCT
aiua-12464	146	39	hwp4	hwp4	PROPN
aiua-12464	146	40	,	,	PUNCT
aiua-12464	146	41	hwp12	hwp12	PROPN
aiua-12464	146	42	and	and	CCONJ
aiua-12464	146	43	hwp14	hwp14	PROPN
aiua-12464	146	44	)	)	PUNCT
aiua-12464	146	45	has	have	AUX
aiua-12464	146	46	been	be	AUX
aiua-12464	146	47	previously	previously	ADV
aiua-12464	146	48	linked	link	VERB
aiua-12464	146	49	with	with	ADP
aiua-12464	146	50	its	its	PRON
aiua-12464	146	51	adverse	adverse	ADJ
aiua-12464	146	52	effects	effect	NOUN
aiua-12464	146	53	on	on	ADP
aiua-12464	146	54	the	the	DET
aiua-12464	146	55	nucleotide	nucleotide	NOUN
aiua-12464	146	56	-	-	PUNCT
aiua-12464	146	57	binding	bind	VERB
aiua-12464	146	58	domain	domain	NOUN
aiua-12464	146	59	1	1	NUM
aiua-12464	146	60	(	(	PUNCT
aiua-12464	146	61	nbd1	nbd1	PROPN
aiua-12464	146	62	)	)	PUNCT
aiua-12464	146	63	of	of	ADP
aiua-12464	146	64	the	the	DET
aiua-12464	146	65	cftr	cftr	NOUN
aiua-12464	146	66	protein	protein	NOUN
aiua-12464	146	67	.	.	PUNCT
aiua-12464	147	1	the	the	DET
aiua-12464	147	2	v456a	v456a	PROPN
aiua-12464	147	3	mutation	mutation	NOUN
aiua-12464	147	4	refers	refer	VERB
aiua-12464	147	5	to	to	ADP
aiua-12464	147	6	the	the	DET
aiua-12464	147	7	substitution	substitution	NOUN
aiua-12464	147	8	of	of	ADP
aiua-12464	147	9	the	the	DET
aiua-12464	147	10	amino	amino	NOUN
aiua-12464	147	11	acid	acid	NOUN
aiua-12464	147	12	valine	valine	NOUN
aiua-12464	147	13	(	(	PUNCT
aiua-12464	147	14	v	v	NOUN
aiua-12464	147	15	)	)	PUNCT
aiua-12464	147	16	with	with	ADP
aiua-12464	147	17	alanine	alanine	NOUN
aiua-12464	147	18	(	(	PUNCT
aiua-12464	147	19	a	a	NOUN
aiua-12464	147	20	)	)	PUNCT
aiua-12464	147	21	at	at	ADP
aiua-12464	147	22	position	position	NOUN
aiua-12464	147	23	456	456	NUM
aiua-12464	147	24	within	within	ADP
aiua-12464	147	25	nbd1	nbd1	PROPN
aiua-12464	147	26	.	.	PUNCT
aiua-12464	148	1	hope	hope	PROPN
aiua-12464	148	2	server	server	PROPN
aiua-12464	148	3	illustrated	illustrate	VERB
aiua-12464	148	4	that	that	SCONJ
aiua-12464	148	5	mutation	mutation	NOUN
aiua-12464	148	6	driven	drive	VERB
aiua-12464	148	7	physicochemical	physicochemical	ADJ
aiua-12464	148	8	changes	change	NOUN
aiua-12464	148	9	in	in	ADP
aiua-12464	148	10	protein	protein	NOUN
aiua-12464	148	11	might	might	AUX
aiua-12464	148	12	be	be	AUX
aiua-12464	148	13	deleterious	deleterious	ADJ
aiua-12464	148	14	.	.	PUNCT
aiua-12464	149	1	in	in	ADP
aiua-12464	149	2	case	case	NOUN
aiua-12464	149	3	of	of	ADP
aiua-12464	149	4	v456a	v456a	PROPN
aiua-12464	149	5	,	,	PUNCT
aiua-12464	149	6	mutated	mutate	VERB
aiua-12464	149	7	residue	residue	NOUN
aiua-12464	149	8	is	be	AUX
aiua-12464	149	9	smaller	small	ADJ
aiua-12464	149	10	in	in	ADP
aiua-12464	149	11	contrast	contrast	NOUN
aiua-12464	149	12	to	to	ADP
aiua-12464	149	13	wild	wild	ADJ
aiua-12464	149	14	type	type	NOUN
aiua-12464	149	15	and	and	CCONJ
aiua-12464	149	16	mutation	mutation	NOUN
aiua-12464	149	17	is	be	AUX
aiua-12464	149	18	located	locate	VERB
aiua-12464	149	19	within	within	ADP
aiua-12464	149	20	a	a	DET
aiua-12464	149	21	domain	domain	NOUN
aiua-12464	149	22	(	(	PUNCT
aiua-12464	149	23	abc	abc	PROPN
aiua-12464	149	24	transporter	transporter	VERB
aiua-12464	149	25	1	1	NUM
aiua-12464	149	26	as	as	SCONJ
aiua-12464	149	27	annotated	annotate	VERB
aiua-12464	149	28	in	in	ADP
aiua-12464	149	29	uniprot	uniprot	ADJ
aiua-12464	149	30	)	)	PUNCT
aiua-12464	149	31	important	important	ADJ
aiua-12464	149	32	for	for	ADP
aiua-12464	149	33	binding	bind	VERB
aiua-12464	149	34	of	of	ADP
aiua-12464	149	35	other	other	ADJ
aiua-12464	149	36	molecules	molecule	NOUN
aiua-12464	149	37	and	and	CCONJ
aiua-12464	149	38	in	in	ADP
aiua-12464	149	39	contact	contact	NOUN
aiua-12464	149	40	with	with	ADP
aiua-12464	149	41	residues	residue	NOUN
aiua-12464	149	42	in	in	ADP
aiua-12464	149	43	a	a	DET
aiua-12464	149	44	domain	domain	NOUN
aiua-12464	149	45	that	that	PRON
aiua-12464	149	46	is	be	AUX
aiua-12464	149	47	important	important	ADJ
aiua-12464	149	48	for	for	ADP
aiua-12464	149	49	the	the	DET
aiua-12464	149	50	activity	activity	NOUN
aiua-12464	149	51	of	of	ADP
aiua-12464	149	52	the	the	DET
aiua-12464	149	53	protein	protein	NOUN
aiua-12464	149	54	.	.	PUNCT
aiua-12464	150	1	the	the	DET
aiua-12464	150	2	mutation	mutation	NOUN
aiua-12464	150	3	might	might	AUX
aiua-12464	150	4	affect	affect	VERB
aiua-12464	150	5	this	this	DET
aiua-12464	150	6	interaction	interaction	NOUN
aiua-12464	150	7	and	and	CCONJ
aiua-12464	150	8	thereby	thereby	ADV
aiua-12464	150	9	disturb	disturb	VERB
aiua-12464	150	10	signal	signal	NOUN
aiua-12464	150	11	transfer	transfer	NOUN
aiua-12464	150	12	from	from	ADP
aiua-12464	150	13	the	the	DET
aiua-12464	150	14	binding	bind	VERB
aiua-12464	150	15	domain	domain	NOUN
aiua-12464	150	16	to	to	ADP
aiua-12464	150	17	the	the	DET
aiua-12464	150	18	activity	activity	NOUN
aiua-12464	150	19	domain	domain	NOUN
aiua-12464	150	20	(	(	PUNCT
aiua-12464	150	21	figure	figure	NOUN
aiua-12464	150	22	3a	3a	NUM
aiua-12464	150	23	)	)	PUNCT
aiua-12464	150	24	.	.	PUNCT
aiua-12464	151	1	regarding	regard	VERB
aiua-12464	151	2	k464e	k464e	PROPN
aiua-12464	151	3	,	,	PUNCT
aiua-12464	151	4	the	the	DET
aiua-12464	151	5	size	size	NOUN
aiua-12464	151	6	difference	difference	NOUN
aiua-12464	151	7	of	of	ADP
aiua-12464	151	8	mutated	mutate	VERB
aiua-12464	151	9	residue	residue	NOUN
aiua-12464	151	10	(	(	PUNCT
aiua-12464	151	11	smaller	small	ADJ
aiua-12464	151	12	)	)	PUNCT
aiua-12464	151	13	disturbs	disturb	VERB
aiua-12464	151	14	the	the	DET
aiua-12464	151	15	interaction	interaction	NOUN
aiua-12464	151	16	with	with	ADP
aiua-12464	151	17	mg2	mg2	PROPN
aiua-12464	151	18	+	+	CCONJ
aiua-12464	151	19	and	and	CCONJ
aiua-12464	151	20	might	might	AUX
aiua-12464	151	21	result	result	VERB
aiua-12464	151	22	in	in	ADP
aiua-12464	151	23	destabilization	destabilization	NOUN
aiua-12464	151	24	of	of	ADP
aiua-12464	151	25	the	the	DET
aiua-12464	151	26	domain	domain	NOUN
aiua-12464	151	27	as	as	SCONJ
aiua-12464	151	28	divalent	divalent	NOUN
aiua-12464	151	29	cations	cation	NOUN
aiua-12464	151	30	enhance	enhance	VERB
aiua-12464	151	31	atp	atp	PROPN
aiua-12464	151	32	binding	bind	VERB
aiua-12464	151	33	(	(	PUNCT
aiua-12464	151	34	35	35	NUM
aiua-12464	151	35	)	)	PUNCT
aiua-12464	151	36	.	.	PUNCT
aiua-12464	152	1	k464	k464	PROPN
aiua-12464	152	2	interacts	interact	VERB
aiua-12464	152	3	with	with	ADP
aiua-12464	152	4	ligand	ligand	PROPN
aiua-12464	152	5	atp	atp	PROPN
aiua-12464	152	6	which	which	PRON
aiua-12464	152	7	might	might	AUX
aiua-12464	152	8	be	be	AUX
aiua-12464	152	9	disturbed	disturb	VERB
aiua-12464	152	10	by	by	ADP
aiua-12464	152	11	mutation	mutation	NOUN
aiua-12464	152	12	and	and	CCONJ
aiua-12464	152	13	there	there	PRON
aiua-12464	152	14	is	be	VERB
aiua-12464	152	15	also	also	ADV
aiua-12464	152	16	change	change	NOUN
aiua-12464	152	17	in	in	ADP
aiua-12464	152	18	charge	charge	NOUN
aiua-12464	152	19	of	of	ADP
aiua-12464	152	20	mutated	mutate	VERB
aiua-12464	152	21	residue	residue	NOUN
aiua-12464	152	22	(	(	PUNCT
aiua-12464	152	23	negative	negative	ADJ
aiua-12464	152	24	)	)	PUNCT
aiua-12464	152	25	as	as	SCONJ
aiua-12464	152	26	compared	compare	VERB
aiua-12464	152	27	to	to	ADP
aiua-12464	152	28	wild	wild	ADJ
aiua-12464	152	29	type	type	NOUN
aiua-12464	152	30	(	(	PUNCT
aiua-12464	152	31	positive	positive	ADJ
aiua-12464	152	32	)	)	PUNCT
aiua-12464	152	33	where	where	SCONJ
aiua-12464	152	34	changes	change	NOUN
aiua-12464	152	35	in	in	ADP
aiua-12464	152	36	size	size	NOUN
aiua-12464	152	37	and	and	CCONJ
aiua-12464	152	38	charge	charge	NOUN
aiua-12464	152	39	can	can	AUX
aiua-12464	152	40	cause	cause	VERB
aiua-12464	152	41	loss	loss	NOUN
aiua-12464	152	42	of	of	ADP
aiua-12464	152	43	interaction	interaction	NOUN
aiua-12464	152	44	with	with	ADP
aiua-12464	152	45	ligand	ligand	NOUN
aiua-12464	152	46	(	(	PUNCT
aiua-12464	152	47	figure	figure	NOUN
aiua-12464	152	48	3b	3b	NUM
aiua-12464	152	49	)	)	PUNCT
aiua-12464	152	50	.	.	PUNCT
aiua-12464	153	1	mutations	mutation	NOUN
aiua-12464	153	2	within	within	ADP
aiua-12464	153	3	nbd1	nbd1	PROPN
aiua-12464	153	4	,	,	PUNCT
aiua-12464	153	5	such	such	ADJ
aiua-12464	153	6	as	as	ADP
aiua-12464	153	7	the	the	DET
aiua-12464	153	8	v456a	v456a	PROPN
aiua-12464	153	9	mutation	mutation	NOUN
aiua-12464	153	10	,	,	PUNCT
aiua-12464	153	11	can	can	AUX
aiua-12464	153	12	disrupt	disrupt	VERB
aiua-12464	153	13	these	these	DET
aiua-12464	153	14	processes	process	NOUN
aiua-12464	153	15	,	,	PUNCT
aiua-12464	153	16	leading	lead	VERB
aiua-12464	153	17	to	to	ADP
aiua-12464	153	18	a	a	DET
aiua-12464	153	19	dysfunctional	dysfunctional	ADJ
aiua-12464	153	20	cftr	cftr	NOUN
aiua-12464	153	21	protein	protein	NOUN
aiua-12464	153	22	and	and	CCONJ
aiua-12464	153	23	ultimately	ultimately	ADV
aiua-12464	153	24	contributing	contribute	VERB
aiua-12464	153	25	to	to	ADP
aiua-12464	153	26	the	the	DET
aiua-12464	153	27	development	development	NOUN
aiua-12464	153	28	of	of	ADP
aiua-12464	153	29	cystic	cystic	ADJ
aiua-12464	153	30	fibrosis	fibrosis	NOUN
aiua-12464	153	31	.	.	PUNCT
aiua-12464	154	1	therefore	therefore	ADV
aiua-12464	154	2	,	,	PUNCT
aiua-12464	154	3	its	its	PRON
aiua-12464	154	4	presence	presence	NOUN
aiua-12464	154	5	in	in	ADP
aiua-12464	154	6	cbavd	cbavd	ADJ
aiua-12464	154	7	patients	patient	NOUN
aiua-12464	154	8	emphasize	emphasize	VERB
aiua-12464	154	9	the	the	DET
aiua-12464	154	10	significance	significance	NOUN
aiua-12464	154	11	of	of	ADP
aiua-12464	154	12	the	the	DET
aiua-12464	154	13	mutation	mutation	NOUN
aiua-12464	154	14	in	in	ADP
aiua-12464	154	15	the	the	DET
aiua-12464	154	16	prevalence	prevalence	NOUN
aiua-12464	154	17	of	of	ADP
aiua-12464	154	18	the	the	DET
aiua-12464	154	19	disease	disease	NOUN
aiua-12464	154	20	.	.	PUNCT
aiua-12464	155	1	the	the	DET
aiua-12464	155	2	specific	specific	ADJ
aiua-12464	155	3	effects	effect	NOUN
aiua-12464	155	4	of	of	ADP
aiua-12464	155	5	the	the	DET
aiua-12464	155	6	v456a	v456a	PROPN
aiua-12464	155	7	and	and	CCONJ
aiua-12464	155	8	k464e	k464e	PROPN
aiua-12464	155	9	mutations	mutation	NOUN
aiua-12464	155	10	on	on	ADP
aiua-12464	155	11	the	the	DET
aiua-12464	155	12	cftr	cftr	NOUN
aiua-12464	155	13	protein	protein	NOUN
aiua-12464	155	14	domain	domain	NOUN
aiua-12464	155	15	may	may	AUX
aiua-12464	155	16	vary	vary	VERB
aiua-12464	155	17	,	,	PUNCT
aiua-12464	155	18	and	and	CCONJ
aiua-12464	155	19	further	further	ADJ
aiua-12464	155	20	research	research	NOUN
aiua-12464	155	21	may	may	AUX
aiua-12464	155	22	be	be	AUX
aiua-12464	155	23	required	require	VERB
aiua-12464	155	24	to	to	PART
aiua-12464	155	25	fully	fully	ADV
aiua-12464	155	26	understand	understand	VERB
aiua-12464	155	27	its	its	PRON
aiua-12464	155	28	impact	impact	NOUN
aiua-12464	155	29	on	on	ADP
aiua-12464	155	30	the	the	DET
aiua-12464	155	31	progression	progression	NOUN
aiua-12464	155	32	of	of	ADP
aiua-12464	155	33	cbavd	cbavd	NOUN
aiua-12464	155	34	disease	disease	NOUN
aiua-12464	155	35	.	.	PUNCT
aiua-12464	156	1	the	the	DET
aiua-12464	156	2	new	new	ADJ
aiua-12464	156	3	silent	silent	ADJ
aiua-12464	156	4	mutations	mutation	NOUN
aiua-12464	156	5	s431s	s431s	PROPN
aiua-12464	156	6	and	and	CCONJ
aiua-12464	156	7	g437	g437	PROPN
aiua-12464	156	8	g	g	PROPN
aiua-12464	156	9	found	find	VERB
aiua-12464	156	10	in	in	ADP
aiua-12464	156	11	two	two	NUM
aiua-12464	156	12	of	of	ADP
aiua-12464	156	13	the	the	DET
aiua-12464	156	14	patients	patient	NOUN
aiua-12464	156	15	do	do	AUX
aiua-12464	156	16	not	not	PART
aiua-12464	156	17	seem	seem	VERB
aiua-12464	156	18	to	to	PART
aiua-12464	156	19	disrupt	disrupt	VERB
aiua-12464	156	20	the	the	DET
aiua-12464	156	21	coding	coding	NOUN
aiua-12464	156	22	sequencing	sequencing	NOUN
aiua-12464	156	23	as	as	SCONJ
aiua-12464	156	24	the	the	DET
aiua-12464	156	25	resultant	resultant	NOUN
aiua-12464	156	26	protein	protein	NOUN
aiua-12464	156	27	remains	remain	VERB
aiua-12464	156	28	the	the	DET
aiua-12464	156	29	same	same	ADJ
aiua-12464	156	30	but	but	CCONJ
aiua-12464	156	31	further	further	ADJ
aiua-12464	156	32	analysis	analysis	NOUN
aiua-12464	156	33	is	be	AUX
aiua-12464	156	34	needed	need	VERB
aiua-12464	156	35	for	for	ADP
aiua-12464	156	36	a	a	DET
aiua-12464	156	37	more	more	ADV
aiua-12464	156	38	concrete	concrete	ADJ
aiua-12464	156	39	ruling	ruling	NOUN
aiua-12464	156	40	as	as	SCONJ
aiua-12464	156	41	their	their	PRON
aiua-12464	156	42	influence	influence	NOUN
aiua-12464	156	43	as	as	ADP
aiua-12464	156	44	single	single	ADJ
aiua-12464	156	45	nucleotide	nucleotide	NOUN
aiua-12464	156	46	polymorphism	polymorphism	NOUN
aiua-12464	156	47	can	can	AUX
aiua-12464	156	48	not	not	PART
aiua-12464	156	49	be	be	AUX
aiua-12464	156	50	ignored	ignore	VERB
aiua-12464	156	51	based	base	VERB
aiua-12464	156	52	on	on	ADP
aiua-12464	156	53	our	our	PRON
aiua-12464	156	54	study	study	NOUN
aiua-12464	156	55	,	,	PUNCT
aiua-12464	156	56	which	which	PRON
aiua-12464	156	57	involves	involve	VERB
aiua-12464	156	58	small	small	ADJ
aiua-12464	156	59	number	number	NOUN
aiua-12464	156	60	of	of	ADP
aiua-12464	156	61	cbavd	cbavd	NOUN
aiua-12464	156	62	patients	patient	NOUN
aiua-12464	156	63	and	and	CCONJ
aiua-12464	156	64	lacks	lack	VERB
aiua-12464	156	65	the	the	DET
aiua-12464	156	66	inclusion	inclusion	NOUN
aiua-12464	156	67	of	of	ADP
aiua-12464	156	68	multiple	multiple	ADJ
aiua-12464	156	69	ethnicities	ethnicity	NOUN
aiua-12464	156	70	in	in	ADP
aiua-12464	156	71	the	the	DET
aiua-12464	156	72	region	region	NOUN
aiua-12464	156	73	.	.	PUNCT
aiua-12464	157	1	on	on	ADP
aiua-12464	157	2	the	the	DET
aiua-12464	157	3	basis	basis	NOUN
aiua-12464	157	4	of	of	ADP
aiua-12464	157	5	these	these	DET
aiua-12464	157	6	promising	promising	ADJ
aiua-12464	157	7	results	result	NOUN
aiua-12464	157	8	,	,	PUNCT
aiua-12464	157	9	further	further	ADJ
aiua-12464	157	10	research	research	NOUN
aiua-12464	157	11	needs	need	VERB
aiua-12464	157	12	to	to	PART
aiua-12464	157	13	be	be	AUX
aiua-12464	157	14	planned	plan	VERB
aiua-12464	157	15	on	on	ADP
aiua-12464	157	16	a	a	DET
aiua-12464	157	17	larger	large	ADJ
aiua-12464	157	18	sample	sample	NOUN
aiua-12464	157	19	size	size	NOUN
aiua-12464	157	20	.	.	PUNCT
aiua-12464	158	1	furthermore	furthermore	ADV
aiua-12464	158	2	,	,	PUNCT
aiua-12464	158	3	whole	whole	ADJ
aiua-12464	158	4	genome	genome	NOUN
aiua-12464	158	5	sequencing	sequencing	NOUN
aiua-12464	158	6	and	and	CCONJ
aiua-12464	158	7	protein	protein	NOUN
aiua-12464	158	8	analysis	analysis	NOUN
aiua-12464	158	9	are	be	AUX
aiua-12464	158	10	required	require	VERB
aiua-12464	158	11	to	to	PART
aiua-12464	158	12	be	be	AUX
aiua-12464	158	13	performed	perform	VERB
aiua-12464	158	14	for	for	ADP
aiua-12464	158	15	more	more	ADV
aiua-12464	158	16	sensitive	sensitive	ADJ
aiua-12464	158	17	and	and	CCONJ
aiua-12464	158	18	consistent	consistent	ADJ
aiua-12464	158	19	results	result	NOUN
aiua-12464	158	20	.	.	PUNCT
aiua-12464	159	1	hence	hence	ADV
aiua-12464	159	2	,	,	PUNCT
aiua-12464	159	3	there	there	PRON
aiua-12464	159	4	is	be	VERB
aiua-12464	159	5	an	an	DET
aiua-12464	159	6	extreme	extreme	ADJ
aiua-12464	159	7	need	need	NOUN
aiua-12464	159	8	for	for	ADP
aiua-12464	159	9	further	further	ADJ
aiua-12464	159	10	investigations	investigation	NOUN
aiua-12464	159	11	in	in	ADP
aiua-12464	159	12	genetics	genetic	NOUN
aiua-12464	159	13	and	and	CCONJ
aiua-12464	159	14	epigenetics	epigenetic	NOUN
aiua-12464	159	15	to	to	PART
aiua-12464	159	16	provide	provide	VERB
aiua-12464	159	17	deep	deep	ADJ
aiua-12464	159	18	understanding	understanding	NOUN
aiua-12464	159	19	of	of	ADP
aiua-12464	159	20	male	male	ADJ
aiua-12464	159	21	infertility	infertility	NOUN
aiua-12464	159	22	,	,	PUNCT
aiua-12464	159	23	especially	especially	ADV
aiua-12464	159	24	gene	gene	NOUN
aiua-12464	159	25	-	-	PUNCT
aiua-12464	159	26	environmental	environmental	ADJ
aiua-12464	159	27	interaction	interaction	NOUN
aiua-12464	159	28	,	,	PUNCT
aiua-12464	159	29	not	not	PART
aiua-12464	159	30	just	just	ADV
aiua-12464	159	31	to	to	PART
aiua-12464	159	32	provide	provide	VERB
aiua-12464	159	33	detailed	detailed	ADJ
aiua-12464	159	34	information	information	NOUN
aiua-12464	159	35	about	about	ADP
aiua-12464	159	36	its	its	PRON
aiua-12464	159	37	etiology	etiology	NOUN
aiua-12464	159	38	but	but	CCONJ
aiua-12464	159	39	also	also	ADV
aiua-12464	159	40	to	to	PART
aiua-12464	159	41	help	help	VERB
aiua-12464	159	42	in	in	ADP
aiua-12464	159	43	proper	proper	ADJ
aiua-12464	159	44	genetic	genetic	ADJ
aiua-12464	159	45	counseling	counseling	NOUN
aiua-12464	159	46	.	.	PUNCT
aiua-12464	160	1	also	also	ADV
aiua-12464	160	2	,	,	PUNCT
aiua-12464	160	3	further	further	ADJ
aiua-12464	160	4	studies	study	NOUN
aiua-12464	160	5	will	will	AUX
aiua-12464	160	6	be	be	AUX
aiua-12464	160	7	beneficial	beneficial	ADJ
aiua-12464	160	8	to	to	PART
aiua-12464	160	9	develop	develop	VERB
aiua-12464	160	10	preventive	preventive	ADJ
aiua-12464	160	11	measures	measure	NOUN
aiua-12464	160	12	and	and	CCONJ
aiua-12464	160	13	therapies	therapy	NOUN
aiua-12464	160	14	.	.	PUNCT
aiua-12464	161	1	acknowledgments	acknowledgment	NOUN
aiua-12464	161	2	we	we	PRON
aiua-12464	161	3	acknowledge	acknowledge	VERB
aiua-12464	161	4	the	the	DET
aiua-12464	161	5	contribution	contribution	NOUN
aiua-12464	161	6	of	of	ADP
aiua-12464	161	7	rana	rana	PROPN
aiua-12464	161	8	salman	salman	PROPN
aiua-12464	161	9	anjum	anjum	PROPN
aiua-12464	161	10	for	for	ADP
aiua-12464	161	11	his	his	PRON
aiua-12464	161	12	valuable	valuable	ADJ
aiua-12464	161	13	insight	insight	NOUN
aiua-12464	161	14	about	about	ADP
aiua-12464	161	15	protein	protein	NOUN
aiua-12464	161	16	structure	structure	NOUN
aiua-12464	161	17	analysis	analysis	NOUN
aiua-12464	161	18	and	and	CCONJ
aiua-12464	161	19	dr	dr	PROPN
aiua-12464	161	20	.	.	PROPN
aiua-12464	161	21	iahtisham	iahtisham	PROPN
aiua-12464	161	22	ul	ul	INTJ
aiua-12464	161	23	haq	haq	PROPN
aiua-12464	161	24	for	for	ADP
aiua-12464	161	25	his	his	PRON
aiua-12464	161	26	guidance	guidance	NOUN
aiua-12464	161	27	.	.	PUNCT
aiua-12464	162	1	funding	funding	NOUN
aiua-12464	162	2	disclosure	disclosure	NOUN
aiua-12464	162	3	this	this	DET
aiua-12464	162	4	study	study	NOUN
aiua-12464	162	5	was	be	AUX
aiua-12464	162	6	funded	fund	VERB
aiua-12464	162	7	by	by	ADP
aiua-12464	162	8	the	the	DET
aiua-12464	162	9	kauser	kauser	PROPN
aiua-12464	162	10	abdulla	abdulla	PROPN
aiua-12464	162	11	malik	malik	PROPN
aiua-12464	162	12	school	school	PROPN
aiua-12464	162	13	of	of	ADP
aiua-12464	162	14	life	life	NOUN
aiua-12464	162	15	sciences	sciences	PROPN
aiua-12464	162	16	,	,	PUNCT
aiua-12464	162	17	forman	forman	PROPN
aiua-12464	162	18	christian	christian	PROPN
aiua-12464	162	19	college	college	PROPN
aiua-12464	162	20	(	(	PUNCT
aiua-12464	162	21	a	a	DET
aiua-12464	162	22	chartered	chartered	ADJ
aiua-12464	162	23	university	university	NOUN
aiua-12464	162	24	)	)	PUNCT
aiua-12464	162	25	lahore	lahore	PROPN
aiua-12464	162	26	,	,	PUNCT
aiua-12464	162	27	pakistan	pakistan	PROPN
aiua-12464	162	28	.	.	PUNCT
aiua-12464	163	1	references	reference	NOUN
aiua-12464	163	2	1	1	NUM
aiua-12464	163	3	.	.	PUNCT
aiua-12464	164	1	cai	cai	PROPN
aiua-12464	164	2	h	h	PROPN
aiua-12464	164	3	,	,	PUNCT
aiua-12464	164	4	qing	qe	VERB
aiua-12464	164	5	x	x	SYM
aiua-12464	164	6	,	,	PUNCT
aiua-12464	164	7	niringiyumukiza	niringiyumukiza	PROPN
aiua-12464	164	8	jd	jd	PROPN
aiua-12464	164	9	,	,	PUNCT
aiua-12464	164	10	et	et	PROPN
aiua-12464	164	11	al	al	PROPN
aiua-12464	164	12	.	.	PROPN
aiua-12464	165	1	cftr	cftr	PROPN
aiua-12464	165	2	variants	variant	NOUN
aiua-12464	165	3	and	and	CCONJ
aiua-12464	165	4	renal	renal	ADJ
aiua-12464	165	5	abnormalities	abnormality	NOUN
aiua-12464	165	6	in	in	ADP
aiua-12464	165	7	males	male	NOUN
aiua-12464	165	8	with	with	ADP
aiua-12464	165	9	congenital	congenital	ADJ
aiua-12464	165	10	unilateral	unilateral	ADJ
aiua-12464	165	11	absence	absence	NOUN
aiua-12464	165	12	of	of	ADP
aiua-12464	165	13	the	the	DET
aiua-12464	165	14	vas	vas	X
aiua-12464	165	15	deferens	deferens	PROPN
aiua-12464	165	16	(	(	PUNCT
aiua-12464	165	17	cuavd	cuavd	NOUN
aiua-12464	165	18	):	):	PUNCT
aiua-12464	165	19	a	a	DET
aiua-12464	165	20	systematic	systematic	ADJ
aiua-12464	165	21	review	review	NOUN
aiua-12464	165	22	and	and	CCONJ
aiua-12464	165	23	meta	meta	ADJ
aiua-12464	165	24	-	-	PUNCT
aiua-12464	165	25	analysis	analysis	NOUN
aiua-12464	165	26	of	of	ADP
aiua-12464	165	27	observational	observational	ADJ
aiua-12464	165	28	studies	study	NOUN
aiua-12464	165	29	.	.	PUNCT
aiua-12464	166	1	genet	genet	PROPN
aiua-12464	166	2	med	med	PROPN
aiua-12464	166	3	.	.	PROPN
aiua-12464	166	4	2019	2019	NUM
aiua-12464	166	5	;	;	PUNCT
aiua-12464	166	6	21:826	21:826	NUM
aiua-12464	166	7	-	-	SYM
aiua-12464	166	8	36	36	NUM
aiua-12464	166	9	.	.	NOUN
aiua-12464	167	1	2	2	X
aiua-12464	167	2	.	.	X
aiua-12464	167	3	halder	halder	PROPN
aiua-12464	167	4	a	a	PROPN
aiua-12464	167	5	,	,	PUNCT
aiua-12464	167	6	pandey	pandey	PROPN
aiua-12464	167	7	d.	d.	PROPN
aiua-12464	167	8	cftr	cftr	PROPN
aiua-12464	167	9	gene	gene	NOUN
aiua-12464	167	10	variants	variant	NOUN
aiua-12464	167	11	in	in	ADP
aiua-12464	167	12	indian	indian	ADJ
aiua-12464	167	13	congenital	congenital	ADJ
aiua-12464	167	14	bilateral	bilateral	ADJ
aiua-12464	167	15	absence	absence	NOUN
aiua-12464	167	16	of	of	ADP
aiua-12464	167	17	vas	vas	X
aiua-12464	167	18	deferens	deferens	PROPN
aiua-12464	167	19	&	&	CCONJ
aiua-12464	167	20	its	its	PRON
aiua-12464	167	21	relevance	relevance	NOUN
aiua-12464	167	22	in	in	ADP
aiua-12464	167	23	genetic	genetic	ADJ
aiua-12464	167	24	counselling	counselling	NOUN
aiua-12464	167	25	.	.	PUNCT
aiua-12464	168	1	indian	indian	PROPN
aiua-12464	168	2	j	j	PROPN
aiua-12464	168	3	med	med	PROPN
aiua-12464	168	4	res	re	NOUN
aiua-12464	168	5	.	.	PUNCT
aiua-12464	168	6	2020	2020	NUM
aiua-12464	168	7	;	;	PUNCT
aiua-12464	168	8	152:535	152:535	NUM
aiua-12464	168	9	-	-	SYM
aiua-12464	168	10	7	7	NUM
aiua-12464	168	11	.	.	NOUN
aiua-12464	168	12	3	3	NUM
aiua-12464	168	13	.	.	X
aiua-12464	168	14	cai	cai	PROPN
aiua-12464	169	1	z	z	PROPN
aiua-12464	169	2	,	,	PUNCT
aiua-12464	169	3	li	li	PROPN
aiua-12464	169	4	h.	h.	PROPN
aiua-12464	169	5	congenital	congenital	ADJ
aiua-12464	169	6	bilateral	bilateral	ADJ
aiua-12464	169	7	absence	absence	NOUN
aiua-12464	169	8	of	of	ADP
aiua-12464	169	9	the	the	DET
aiua-12464	169	10	vas	vas	X
aiua-12464	169	11	deferens	deferens	PROPN
aiua-12464	169	12	.	.	PUNCT
aiua-12464	170	1	front	front	ADJ
aiua-12464	170	2	genet	genet	PROPN
aiua-12464	170	3	.	.	PUNCT
aiua-12464	171	1	2022	2022	NUM
aiua-12464	171	2	;	;	PUNCT
aiua-12464	171	3	13:775123	13:775123	NUM
aiua-12464	171	4	.	.	PUNCT
aiua-12464	172	1	4	4	X
aiua-12464	172	2	.	.	X
aiua-12464	172	3	ferlin	ferlin	PROPN
aiua-12464	172	4	a	a	PROPN
aiua-12464	172	5	,	,	PUNCT
aiua-12464	172	6	dipresa	dipresa	NOUN
aiua-12464	172	7	s	s	PROPN
aiua-12464	172	8	,	,	PUNCT
aiua-12464	172	9	delbarba	delbarba	NOUN
aiua-12464	172	10	a	a	X
aiua-12464	172	11	,	,	PUNCT
aiua-12464	172	12	et	et	PROPN
aiua-12464	172	13	al	al	PROPN
aiua-12464	172	14	.	.	PROPN
aiua-12464	172	15	contemporary	contemporary	ADJ
aiua-12464	172	16	geneticsbased	geneticsbase	VERB
aiua-12464	172	17	diagnostics	diagnostic	NOUN
aiua-12464	172	18	of	of	ADP
aiua-12464	172	19	male	male	ADJ
aiua-12464	172	20	infertility	infertility	NOUN
aiua-12464	172	21	.	.	PUNCT
aiua-12464	173	1	expert	expert	NOUN
aiua-12464	173	2	rev	rev	VERB
aiua-12464	173	3	mol	mol	ADP
aiua-12464	173	4	diagn	diagn	NOUN
aiua-12464	173	5	.	.	PUNCT
aiua-12464	174	1	2019	2019	NUM
aiua-12464	174	2	;	;	PUNCT
aiua-12464	174	3	19:623	19:623	NUM
aiua-12464	174	4	-	-	SYM
aiua-12464	174	5	33	33	NUM
aiua-12464	174	6	.	.	NOUN
aiua-12464	175	1	5	5	NUM
aiua-12464	175	2	.	.	X
aiua-12464	175	3	daudin	daudin	VERB
aiua-12464	175	4	m	m	PROPN
aiua-12464	175	5	,	,	PUNCT
aiua-12464	175	6	bieth	bieth	PROPN
aiua-12464	175	7	e	e	NOUN
aiua-12464	175	8	,	,	PUNCT
aiua-12464	175	9	bujan	bujan	NOUN
aiua-12464	175	10	l	l	NOUN
aiua-12464	175	11	,	,	PUNCT
aiua-12464	175	12	et	et	PROPN
aiua-12464	175	13	al	al	PROPN
aiua-12464	175	14	.	.	PUNCT
aiua-12464	176	1	congenital	congenital	ADJ
aiua-12464	176	2	bilateral	bilateral	ADJ
aiua-12464	176	3	absence	absence	NOUN
aiua-12464	176	4	of	of	ADP
aiua-12464	176	5	the	the	DET
aiua-12464	176	6	vas	vas	X
aiua-12464	176	7	deferens	deferens	PROPN
aiua-12464	176	8	:	:	PUNCT
aiua-12464	176	9	clinical	clinical	ADJ
aiua-12464	176	10	characteristics	characteristic	NOUN
aiua-12464	176	11	,	,	PUNCT
aiua-12464	176	12	biological	biological	ADJ
aiua-12464	176	13	parameters	parameter	NOUN
aiua-12464	176	14	,	,	PUNCT
aiua-12464	176	15	cystic	cystic	ADJ
aiua-12464	176	16	fibrosis	fibrosis	NOUN
aiua-12464	176	17	transmembrane	transmembrane	NOUN
aiua-12464	176	18	conductance	conductance	NOUN
aiua-12464	176	19	regulator	regulator	NOUN
aiua-12464	176	20	gene	gene	NOUN
aiua-12464	176	21	mutations	mutation	NOUN
aiua-12464	176	22	,	,	PUNCT
aiua-12464	176	23	and	and	CCONJ
aiua-12464	176	24	implications	implication	NOUN
aiua-12464	176	25	for	for	ADP
aiua-12464	176	26	genetic	genetic	ADJ
aiua-12464	176	27	counseling	counseling	NOUN
aiua-12464	176	28	.	.	PUNCT
aiua-12464	177	1	fertil	fertil	PROPN
aiua-12464	177	2	steril	steril	PROPN
aiua-12464	177	3	.	.	PROPN
aiua-12464	177	4	2000	2000	NUM
aiua-12464	177	5	;	;	PUNCT
aiua-12464	177	6	74:1164	74:1164	NOUN
aiua-12464	177	7	-	-	SYM
aiua-12464	177	8	74	74	NUM
aiua-12464	177	9	.	.	PUNCT
aiua-12464	178	1	6	6	NUM
aiua-12464	178	2	.	.	X
aiua-12464	178	3	mieusset	mieusset	VERB
aiua-12464	178	4	r	r	NOUN
aiua-12464	178	5	,	,	PUNCT
aiua-12464	178	6	bieth	bieth	NOUN
aiua-12464	178	7	e	e	PROPN
aiua-12464	178	8	,	,	PUNCT
aiua-12464	178	9	daudin	daudin	VERB
aiua-12464	178	10	m	m	PRON
aiua-12464	178	11	,	,	PUNCT
aiua-12464	178	12	et	et	PROPN
aiua-12464	178	13	al	al	PROPN
aiua-12464	178	14	.	.	PUNCT
aiua-12464	179	1	male	male	ADJ
aiua-12464	179	2	partners	partner	NOUN
aiua-12464	179	3	of	of	ADP
aiua-12464	179	4	infertile	infertile	ADJ
aiua-12464	179	5	couples	couple	NOUN
aiua-12464	179	6	with	with	ADP
aiua-12464	179	7	congenital	congenital	ADJ
aiua-12464	179	8	unilateral	unilateral	ADJ
aiua-12464	179	9	absence	absence	NOUN
aiua-12464	179	10	of	of	ADP
aiua-12464	179	11	the	the	DET
aiua-12464	179	12	vas	vas	X
aiua-12464	179	13	deferens	deferens	PROPN
aiua-12464	179	14	are	be	AUX
aiua-12464	179	15	mainly	mainly	ADV
aiua-12464	179	16	non	non	ADJ
aiua-12464	179	17	-	-	ADJ
aiua-12464	179	18	azoospermic	azoospermic	ADJ
aiua-12464	179	19	.	.	PUNCT
aiua-12464	180	1	andrology	andrology	PROPN
aiua-12464	180	2	.	.	PUNCT
aiua-12464	181	1	2020	2020	NUM
aiua-12464	181	2	;	;	PUNCT
aiua-12464	181	3	8:645	8:645	X
aiua-12464	181	4	-	-	SYM
aiua-12464	181	5	53	53	NUM
aiua-12464	181	6	.	.	PUNCT
aiua-12464	182	1	7	7	X
aiua-12464	182	2	.	.	NUM
aiua-12464	182	3	bieth	bieth	PROPN
aiua-12464	182	4	e	e	PROPN
aiua-12464	182	5	,	,	PUNCT
aiua-12464	182	6	hamdi	hamdi	PROPN
aiua-12464	182	7	sm	sm	PROPN
aiua-12464	182	8	,	,	PUNCT
aiua-12464	182	9	mieusset	mieusset	VERB
aiua-12464	182	10	r.	r.	PROPN
aiua-12464	182	11	genetics	genetics	PROPN
aiua-12464	182	12	of	of	ADP
aiua-12464	182	13	the	the	DET
aiua-12464	182	14	congenital	congenital	ADJ
aiua-12464	182	15	absence	absence	NOUN
aiua-12464	182	16	of	of	ADP
aiua-12464	182	17	the	the	DET
aiua-12464	182	18	vas	vas	X
aiua-12464	182	19	deferens	deferens	PROPN
aiua-12464	182	20	.	.	PUNCT
aiua-12464	183	1	hum	hum	PROPN
aiua-12464	183	2	genet	genet	PROPN
aiua-12464	183	3	.	.	PUNCT
aiua-12464	184	1	2021	2021	NUM
aiua-12464	184	2	;	;	PUNCT
aiua-12464	185	1	140:59	140:59	NUM
aiua-12464	185	2	-	-	SYM
aiua-12464	185	3	76	76	NUM
aiua-12464	185	4	.	.	NOUN
aiua-12464	185	5	8	8	NUM
aiua-12464	185	6	.	.	X
aiua-12464	185	7	casals	casal	NOUN
aiua-12464	185	8	t	t	PROPN
aiua-12464	185	9	,	,	PUNCT
aiua-12464	185	10	bassas	bassas	PROPN
aiua-12464	185	11	l	l	NOUN
aiua-12464	185	12	,	,	PUNCT
aiua-12464	185	13	egozcue	egozcue	PROPN
aiua-12464	185	14	s	s	PROPN
aiua-12464	185	15	,	,	PUNCT
aiua-12464	185	16	et	et	PROPN
aiua-12464	185	17	al	al	PROPN
aiua-12464	185	18	.	.	PROPN
aiua-12464	185	19	heterogeneity	heterogeneity	PROPN
aiua-12464	185	20	for	for	ADP
aiua-12464	185	21	mutations	mutation	NOUN
aiua-12464	185	22	in	in	ADP
aiua-12464	185	23	the	the	DET
aiua-12464	185	24	cftr	cftr	NOUN
aiua-12464	185	25	gene	gene	NOUN
aiua-12464	185	26	and	and	CCONJ
aiua-12464	185	27	clinical	clinical	ADJ
aiua-12464	185	28	correlations	correlation	NOUN
aiua-12464	185	29	in	in	ADP
aiua-12464	185	30	patients	patient	NOUN
aiua-12464	185	31	with	with	ADP
aiua-12464	185	32	congenital	congenital	ADJ
aiua-12464	185	33	absence	absence	NOUN
aiua-12464	185	34	of	of	ADP
aiua-12464	185	35	the	the	DET
aiua-12464	185	36	vas	vas	X
aiua-12464	185	37	deferens	deferens	PROPN
aiua-12464	185	38	.	.	PUNCT
aiua-12464	186	1	hum	hum	PROPN
aiua-12464	186	2	reprod	reprod	PROPN
aiua-12464	186	3	.	.	PUNCT
aiua-12464	187	1	2000	2000	NUM
aiua-12464	187	2	;	;	PUNCT
aiua-12464	187	3	15:1476	15:1476	NUM
aiua-12464	187	4	-	-	NUM
aiua-12464	187	5	83	83	NUM
aiua-12464	187	6	.	.	PUNCT
aiua-12464	188	1	9	9	NUM
aiua-12464	188	2	.	.	X
aiua-12464	188	3	akinsal	akinsal	PROPN
aiua-12464	188	4	ec	ec	PROPN
aiua-12464	188	5	,	,	PUNCT
aiua-12464	188	6	baydilli	baydilli	PROPN
aiua-12464	188	7	n	n	PROPN
aiua-12464	188	8	,	,	PUNCT
aiua-12464	188	9	dogan	dogan	PROPN
aiua-12464	188	10	me	i	PRON
aiua-12464	188	11	,	,	PUNCT
aiua-12464	188	12	ekmekcioglu	ekmekcioglu	PROPN
aiua-12464	188	13	o.	o.	NOUN
aiua-12464	188	14	comorbidity	comorbidity	NOUN
aiua-12464	188	15	of	of	ADP
aiua-12464	188	16	the	the	DET
aiua-12464	188	17	congenital	congenital	ADJ
aiua-12464	188	18	absence	absence	NOUN
aiua-12464	188	19	of	of	ADP
aiua-12464	188	20	the	the	DET
aiua-12464	188	21	vas	vas	X
aiua-12464	188	22	deferens	deferens	PROPN
aiua-12464	188	23	.	.	PUNCT
aiua-12464	189	1	andrologia	andrologia	PROPN
aiua-12464	189	2	.	.	PUNCT
aiua-12464	190	1	2018	2018	NUM
aiua-12464	190	2	;	;	PUNCT
aiua-12464	190	3	50	50	NUM
aiua-12464	190	4	:	:	PUNCT
aiua-12464	190	5	e12994	e12994	NOUN
aiua-12464	190	6	.	.	PUNCT
aiua-12464	191	1	10	10	NUM
aiua-12464	191	2	.	.	PUNCT
aiua-12464	192	1	li	li	PROPN
aiua-12464	192	2	c	c	PROPN
aiua-12464	192	3	-	-	PUNCT
aiua-12464	192	4	y	y	PROPN
aiua-12464	192	5	,	,	PUNCT
aiua-12464	192	6	jiang	jiang	PROPN
aiua-12464	192	7	l	l	PROPN
aiua-12464	192	8	-	-	PROPN
aiua-12464	192	9	y	y	PROPN
aiua-12464	192	10	,	,	PUNCT
aiua-12464	192	11	chen	chen	PROPN
aiua-12464	192	12	w	w	PROPN
aiua-12464	192	13	-	-	PROPN
aiua-12464	192	14	y	y	PROPN
aiua-12464	192	15	,	,	PUNCT
aiua-12464	192	16	et	et	PROPN
aiua-12464	192	17	al	al	PROPN
aiua-12464	192	18	.	.	PROPN
aiua-12464	192	19	cftr	cftr	PROPN
aiua-12464	192	20	is	be	AUX
aiua-12464	192	21	essential	essential	ADJ
aiua-12464	192	22	for	for	ADP
aiua-12464	192	23	sperm	sperm	NOUN
aiua-12464	192	24	fertilizing	fertilizing	NOUN
aiua-12464	192	25	capacity	capacity	NOUN
aiua-12464	192	26	and	and	CCONJ
aiua-12464	192	27	is	be	AUX
aiua-12464	192	28	correlated	correlate	VERB
aiua-12464	192	29	with	with	ADP
aiua-12464	192	30	sperm	sperm	NOUN
aiua-12464	192	31	quality	quality	NOUN
aiua-12464	192	32	in	in	ADP
aiua-12464	192	33	humans	human	NOUN
aiua-12464	192	34	.	.	PUNCT
aiua-12464	193	1	human	human	ADJ
aiua-12464	193	2	reproduction	reproduction	NOUN
aiua-12464	193	3	.	.	PUNCT
aiua-12464	194	1	2010	2010	NUM
aiua-12464	194	2	;	;	PUNCT
aiua-12464	194	3	25:317	25:317	NUM
aiua-12464	194	4	-	-	SYM
aiua-12464	194	5	27	27	NUM
aiua-12464	194	6	.	.	PUNCT
aiua-12464	195	1	11	11	NUM
aiua-12464	195	2	.	.	PUNCT
aiua-12464	196	1	gaillard	gaillard	PROPN
aiua-12464	196	2	da	da	PROPN
aiua-12464	196	3	,	,	PUNCT
aiua-12464	196	4	carre	carre	NOUN
aiua-12464	196	5	-	-	PUNCT
aiua-12464	196	6	pigeon	pigeon	NOUN
aiua-12464	196	7	f	f	NOUN
aiua-12464	196	8	,	,	PUNCT
aiua-12464	196	9	lallemand	lallemand	PROPN
aiua-12464	196	10	a.	a.	PROPN
aiua-12464	196	11	normal	normal	PROPN
aiua-12464	196	12	vas	vas	X
aiua-12464	196	13	deferens	deferen	NOUN
aiua-12464	196	14	in	in	ADP
aiua-12464	196	15	fetuses	fetus	NOUN
aiua-12464	196	16	with	with	ADP
aiua-12464	196	17	cystic	cystic	ADJ
aiua-12464	196	18	fibrosis	fibrosis	NOUN
aiua-12464	196	19	.	.	PUNCT
aiua-12464	197	1	j	j	PROPN
aiua-12464	197	2	urol	urol	PROPN
aiua-12464	197	3	.	.	PUNCT
aiua-12464	197	4	1997	1997	NUM
aiua-12464	197	5	;	;	PUNCT
aiua-12464	197	6	158:1549	158:1549	NUM
aiua-12464	197	7	-	-	SYM
aiua-12464	197	8	52	52	NUM
aiua-12464	197	9	.	.	PUNCT
aiua-12464	197	10	12	12	NUM
aiua-12464	197	11	.	.	PUNCT
aiua-12464	198	1	hwang	hwang	PROPN
aiua-12464	198	2	tc	tc	PROPN
aiua-12464	198	3	,	,	PUNCT
aiua-12464	198	4	yeh	yeh	PROPN
aiua-12464	198	5	jt	jt	PROPN
aiua-12464	198	6	,	,	PUNCT
aiua-12464	198	7	zhang	zhang	PROPN
aiua-12464	198	8	j	j	PROPN
aiua-12464	198	9	,	,	PUNCT
aiua-12464	198	10	et	et	PROPN
aiua-12464	198	11	al	al	PROPN
aiua-12464	198	12	.	.	PROPN
aiua-12464	198	13	structural	structural	ADJ
aiua-12464	198	14	mechanisms	mechanism	NOUN
aiua-12464	198	15	of	of	ADP
aiua-12464	198	16	cftr	cftr	NOUN
aiua-12464	198	17	function	function	NOUN
aiua-12464	198	18	and	and	CCONJ
aiua-12464	198	19	dysfunction	dysfunction	NOUN
aiua-12464	198	20	.	.	PUNCT
aiua-12464	199	1	j	j	PROPN
aiua-12464	199	2	gen	gen	PROPN
aiua-12464	199	3	physiol	physiol	PROPN
aiua-12464	199	4	.	.	PUNCT
aiua-12464	200	1	2018	2018	NUM
aiua-12464	200	2	;	;	PUNCT
aiua-12464	200	3	150:539	150:539	NOUN
aiua-12464	200	4	-	-	SYM
aiua-12464	200	5	70	70	NUM
aiua-12464	200	6	.	.	PUNCT
aiua-12464	201	1	13	13	NUM
aiua-12464	201	2	.	.	PUNCT
aiua-12464	202	1	shishido	shishido	PROPN
aiua-12464	202	2	h	h	PROPN
aiua-12464	202	3	,	,	PUNCT
aiua-12464	202	4	yoon	yoon	PROPN
aiua-12464	202	5	js	js	PROPN
aiua-12464	202	6	,	,	PUNCT
aiua-12464	202	7	yang	yang	PROPN
aiua-12464	202	8	z	z	PROPN
aiua-12464	202	9	,	,	PUNCT
aiua-12464	202	10	skach	skach	PROPN
aiua-12464	202	11	wr	wr	PROPN
aiua-12464	202	12	.	.	PUNCT
aiua-12464	203	1	cftr	cftr	NOUN
aiua-12464	203	2	trafficking	traffic	VERB
aiua-12464	203	3	mutations	mutation	NOUN
aiua-12464	203	4	disrupt	disrupt	VERB
aiua-12464	203	5	cotranslational	cotranslational	ADJ
aiua-12464	203	6	protein	protein	NOUN
aiua-12464	203	7	folding	fold	VERB
aiua-12464	203	8	by	by	ADP
aiua-12464	203	9	targeting	target	VERB
aiua-12464	203	10	biosynthetic	biosynthetic	ADJ
aiua-12464	203	11	intermediates	intermediate	NOUN
aiua-12464	203	12	.	.	PUNCT
aiua-12464	204	1	nat	nat	PROPN
aiua-12464	204	2	commun	commun	PROPN
aiua-12464	204	3	.	.	PUNCT
aiua-12464	205	1	2020	2020	NUM
aiua-12464	205	2	;	;	PUNCT
aiua-12464	205	3	11:4258	11:4258	NUM
aiua-12464	205	4	.	.	PUNCT
aiua-12464	206	1	14	14	NUM
aiua-12464	206	2	.	.	PUNCT
aiua-12464	207	1	morris	morris	PROPN
aiua-12464	207	2	-	-	PUNCT
aiua-12464	207	3	rosendahl	rosendahl	PROPN
aiua-12464	207	4	dj	dj	PROPN
aiua-12464	207	5	,	,	PUNCT
aiua-12464	207	6	edwards	edwards	PROPN
aiua-12464	207	7	m	m	PROPN
aiua-12464	207	8	,	,	PUNCT
aiua-12464	207	9	mcdonnell	mcdonnell	PROPN
aiua-12464	207	10	mj	mj	PROPN
aiua-12464	207	11	,	,	PUNCT
aiua-12464	207	12	et	et	PROPN
aiua-12464	207	13	al	al	PROPN
aiua-12464	207	14	.	.	PUNCT
aiua-12464	208	1	wholegene	wholegene	PROPN
aiua-12464	208	2	sequencing	sequencing	NOUN
aiua-12464	208	3	of	of	ADP
aiua-12464	208	4	cftr	cftr	PROPN
aiua-12464	208	5	reveals	reveal	VERB
aiua-12464	208	6	a	a	DET
aiua-12464	208	7	high	high	ADJ
aiua-12464	208	8	prevalence	prevalence	NOUN
aiua-12464	208	9	of	of	ADP
aiua-12464	208	10	the	the	DET
aiua-12464	208	11	intronic	intronic	ADJ
aiua-12464	208	12	variant	variant	NOUN
aiua-12464	208	13	c.3874	c.3874	NOUN
aiua-12464	208	14	-	-	NOUN
aiua-12464	208	15	4522a	4522a	NUM
aiua-12464	208	16	>	>	SYM
aiua-12464	208	17	g	g	NOUN
aiua-12464	208	18	in	in	ADP
aiua-12464	208	19	cystic	cystic	ADJ
aiua-12464	208	20	fibrosis	fibrosis	NOUN
aiua-12464	208	21	.	.	PUNCT
aiua-12464	209	1	am	be	AUX
aiua-12464	209	2	j	j	PROPN
aiua-12464	209	3	respir	respir	NOUN
aiua-12464	209	4	crit	crit	PROPN
aiua-12464	209	5	care	care	NOUN
aiua-12464	209	6	med	me	VERB
aiua-12464	209	7	.	.	PUNCT
aiua-12464	210	1	2020	2020	NUM
aiua-12464	210	2	;	;	PUNCT
aiua-12464	210	3	201:1438	201:1438	NUM
aiua-12464	210	4	-	-	SYM
aiua-12464	210	5	41	41	NUM
aiua-12464	210	6	.	.	NOUN
aiua-12464	211	1	15	15	NUM
aiua-12464	211	2	.	.	X
aiua-12464	211	3	indika	indika	PROPN
aiua-12464	211	4	nlr	nlr	PROPN
aiua-12464	211	5	,	,	PUNCT
aiua-12464	211	6	vidanapathirana	vidanapathirana	ADJ
aiua-12464	211	7	dm	dm	PROPN
aiua-12464	211	8	,	,	PUNCT
aiua-12464	211	9	dilanthi	dilanthi	PROPN
aiua-12464	211	10	hw	hw	PROPN
aiua-12464	211	11	,	,	PUNCT
aiua-12464	211	12	et	et	PROPN
aiua-12464	211	13	al	al	PROPN
aiua-12464	211	14	.	.	PROPN
aiua-12464	211	15	phenotypic	phenotypic	PROPN
aiua-12464	211	16	spectrum	spectrum	NOUN
aiua-12464	211	17	and	and	CCONJ
aiua-12464	211	18	genetic	genetic	ADJ
aiua-12464	211	19	heterogeneity	heterogeneity	NOUN
aiua-12464	211	20	of	of	ADP
aiua-12464	211	21	cystic	cystic	ADJ
aiua-12464	211	22	fibrosis	fibrosis	NOUN
aiua-12464	211	23	in	in	ADP
aiua-12464	211	24	sri	sri	PROPN
aiua-12464	211	25	lanka	lanka	PROPN
aiua-12464	211	26	.	.	PUNCT
aiua-12464	212	1	bmc	bmc	PROPN
aiua-12464	212	2	med	med	PROPN
aiua-12464	212	3	genet	genet	NOUN
aiua-12464	212	4	.	.	PUNCT
aiua-12464	213	1	2019	2019	NUM
aiua-12464	213	2	;	;	PUNCT
aiua-12464	213	3	20:89	20:89	NUM
aiua-12464	213	4	.	.	PUNCT
aiua-12464	214	1	16	16	NUM
aiua-12464	214	2	.	.	PUNCT
aiua-12464	215	1	ferlin	ferlin	PROPN
aiua-12464	215	2	a	a	PROPN
aiua-12464	215	3	,	,	PUNCT
aiua-12464	215	4	stuppia	stuppia	PROPN
aiua-12464	215	5	l.	l.	PROPN
aiua-12464	215	6	diagnostics	diagnostic	NOUN
aiua-12464	215	7	of	of	ADP
aiua-12464	215	8	cftr	cftr	NOUN
aiua-12464	215	9	-	-	PUNCT
aiua-12464	215	10	negative	negative	ADJ
aiua-12464	215	11	patients	patient	NOUN
aiua-12464	215	12	with	with	ADP
aiua-12464	215	13	congenital	congenital	ADJ
aiua-12464	215	14	bilateral	bilateral	ADJ
aiua-12464	215	15	absence	absence	NOUN
aiua-12464	215	16	of	of	ADP
aiua-12464	215	17	vas	vas	X
aiua-12464	215	18	deferens	deferens	PROPN
aiua-12464	215	19	:	:	PUNCT
aiua-12464	215	20	which	which	DET
aiua-12464	215	21	mutations	mutation	NOUN
aiua-12464	215	22	are	be	AUX
aiua-12464	215	23	of	of	ADP
aiua-12464	215	24	most	most	ADJ
aiua-12464	215	25	interest	interest	NOUN
aiua-12464	215	26	?	?	PUNCT
aiua-12464	216	1	expert	expert	NOUN
aiua-12464	216	2	rev	rev	VERB
aiua-12464	216	3	mol	mol	ADP
aiua-12464	216	4	diagn	diagn	NOUN
aiua-12464	216	5	.	.	PUNCT
aiua-12464	217	1	2020	2020	NUM
aiua-12464	217	2	;	;	PUNCT
aiua-12464	217	3	20:265	20:265	NUM
aiua-12464	217	4	-	-	SYM
aiua-12464	217	5	7	7	NUM
aiua-12464	217	6	.	.	NUM
aiua-12464	217	7	17	17	NUM
aiua-12464	217	8	.	.	PUNCT
aiua-12464	218	1	gupta	gupta	PROPN
aiua-12464	218	2	n	n	CCONJ
aiua-12464	218	3	,	,	PUNCT
aiua-12464	218	4	sarkar	sarkar	PROPN
aiua-12464	218	5	s	s	PROPN
aiua-12464	218	6	,	,	PUNCT
aiua-12464	218	7	mehta	mehta	PROPN
aiua-12464	218	8	p	p	X
aiua-12464	218	9	,	,	PUNCT
aiua-12464	218	10	et	et	PROPN
aiua-12464	218	11	al	al	PROPN
aiua-12464	218	12	.	.	PUNCT
aiua-12464	218	13	polymorphisms	polymorphism	NOUN
aiua-12464	218	14	in	in	ADP
aiua-12464	218	15	the	the	DET
aiua-12464	218	16	hsf2	hsf2	PROPN
aiua-12464	218	17	,	,	PUNCT
aiua-12464	218	18	lrrc6	lrrc6	PROPN
aiua-12464	218	19	,	,	PUNCT
aiua-12464	218	20	meig1	meig1	NOUN
aiua-12464	218	21	and	and	CCONJ
aiua-12464	218	22	ptip	ptip	NOUN
aiua-12464	218	23	genes	gene	NOUN
aiua-12464	218	24	correlate	correlate	VERB
aiua-12464	218	25	with	with	ADP
aiua-12464	218	26	sperm	sperm	NOUN
aiua-12464	218	27	motility	motility	NOUN
aiua-12464	218	28	in	in	ADP
aiua-12464	218	29	idiopathic	idiopathic	ADJ
aiua-12464	218	30	infertility	infertility	NOUN
aiua-12464	218	31	.	.	PUNCT
aiua-12464	219	1	andrologia	andrologia	NOUN
aiua-12464	219	2	.	.	PUNCT
aiua-12464	220	1	2022	2022	NUM
aiua-12464	220	2	;	;	PUNCT
aiua-12464	220	3	54	54	NUM
aiua-12464	220	4	:	:	PUNCT
aiua-12464	220	5	e14517	e14517	PROPN
aiua-12464	220	6	.	.	PROPN
aiua-12464	220	7	18	18	NUM
aiua-12464	220	8	.	.	PUNCT
aiua-12464	220	9	ashkenazy	ashkenazy	PROPN
aiua-12464	220	10	h	h	PROPN
aiua-12464	220	11	,	,	PUNCT
aiua-12464	220	12	abadi	abadi	PROPN
aiua-12464	220	13	s	s	PROPN
aiua-12464	220	14	,	,	PUNCT
aiua-12464	220	15	martz	martz	PROPN
aiua-12464	220	16	e	e	PROPN
aiua-12464	220	17	,	,	PUNCT
aiua-12464	220	18	et	et	PROPN
aiua-12464	220	19	al	al	PROPN
aiua-12464	220	20	.	.	PROPN
aiua-12464	220	21	consurf	consurf	PROPN
aiua-12464	220	22	2016	2016	NUM
aiua-12464	220	23	:	:	PUNCT
aiua-12464	220	24	an	an	DET
aiua-12464	220	25	archivio	archivio	NOUN
aiua-12464	220	26	italiano	italiano	X
aiua-12464	220	27	di	di	X
aiua-12464	220	28	urologia	urologia	PROPN
aiua-12464	220	29	e	e	PROPN
aiua-12464	220	30	andrologia	andrologia	NOUN
aiua-12464	220	31	2024	2024	NUM
aiua-12464	220	32	;	;	PUNCT
aiua-12464	220	33	96(3):12464	96(3):12464	NUM
aiua-12464	220	34	7	7	NUM
aiua-12464	220	35	cftr	cftr	NOUN
aiua-12464	220	36	exon	exon	NOUN
aiua-12464	220	37	10	10	NUM
aiua-12464	220	38	mutations	mutation	NOUN
aiua-12464	220	39	and	and	CCONJ
aiua-12464	220	40	congenital	congenital	ADJ
aiua-12464	220	41	bilateral	bilateral	ADJ
aiua-12464	220	42	absence	absence	NOUN
aiua-12464	220	43	of	of	ADP
aiua-12464	220	44	vas	vas	X
aiua-12464	220	45	deferens	deferens	PROPN
aiua-12464	220	46	improved	improve	VERB
aiua-12464	220	47	methodology	methodology	NOUN
aiua-12464	220	48	to	to	PART
aiua-12464	220	49	estimate	estimate	VERB
aiua-12464	220	50	and	and	CCONJ
aiua-12464	220	51	visualize	visualize	VERB
aiua-12464	220	52	evolutionary	evolutionary	ADJ
aiua-12464	220	53	conservation	conservation	NOUN
aiua-12464	220	54	in	in	ADP
aiua-12464	220	55	macromolecules	macromolecule	NOUN
aiua-12464	220	56	.	.	PUNCT
aiua-12464	221	1	nucleic	nucleic	ADJ
aiua-12464	221	2	acids	acid	NOUN
aiua-12464	221	3	res	re	NOUN
aiua-12464	221	4	.	.	PROPN
aiua-12464	221	5	2016	2016	NUM
aiua-12464	221	6	;	;	PUNCT
aiua-12464	221	7	44	44	NUM
aiua-12464	221	8	:	:	PUNCT
aiua-12464	221	9	w344	w344	PROPN
aiua-12464	221	10	-	-	PUNCT
aiua-12464	221	11	50	50	NUM
aiua-12464	221	12	.	.	PUNCT
aiua-12464	222	1	19	19	NUM
aiua-12464	222	2	.	.	X
aiua-12464	222	3	venselaar	venselaar	NOUN
aiua-12464	222	4	h	h	PROPN
aiua-12464	222	5	,	,	PUNCT
aiua-12464	222	6	te	te	ADP
aiua-12464	222	7	beek	beek	PROPN
aiua-12464	222	8	ta	ta	PROPN
aiua-12464	222	9	,	,	PUNCT
aiua-12464	222	10	kuipers	kuiper	NOUN
aiua-12464	222	11	rk	rk	VERB
aiua-12464	222	12	,	,	PUNCT
aiua-12464	222	13	et	et	PROPN
aiua-12464	222	14	al	al	PROPN
aiua-12464	222	15	.	.	PUNCT
aiua-12464	223	1	protein	protein	NOUN
aiua-12464	223	2	structure	structure	NOUN
aiua-12464	223	3	analysis	analysis	NOUN
aiua-12464	223	4	of	of	ADP
aiua-12464	223	5	mutations	mutation	NOUN
aiua-12464	223	6	causing	cause	VERB
aiua-12464	223	7	inheritable	inheritable	ADJ
aiua-12464	223	8	diseases	disease	NOUN
aiua-12464	223	9	.	.	PUNCT
aiua-12464	224	1	an	an	DET
aiua-12464	224	2	e	e	NOUN
aiua-12464	224	3	-	-	NOUN
aiua-12464	224	4	science	science	ADJ
aiua-12464	224	5	approach	approach	NOUN
aiua-12464	224	6	with	with	ADP
aiua-12464	224	7	life	life	NOUN
aiua-12464	224	8	scientist	scientist	NOUN
aiua-12464	224	9	friendly	friendly	ADJ
aiua-12464	224	10	interfaces	interface	NOUN
aiua-12464	224	11	.	.	PUNCT
aiua-12464	225	1	bmc	bmc	ADJ
aiua-12464	225	2	bioinformatics	bioinformatic	NOUN
aiua-12464	225	3	.	.	PUNCT
aiua-12464	226	1	2010	2010	NUM
aiua-12464	226	2	;	;	PUNCT
aiua-12464	226	3	11:548	11:548	NUM
aiua-12464	226	4	.	.	PUNCT
aiua-12464	227	1	20	20	NUM
aiua-12464	227	2	.	.	PUNCT
aiua-12464	228	1	giordano	giordano	PROPN
aiua-12464	228	2	sh	sh	PROPN
aiua-12464	228	3	.	.	PROPN
aiua-12464	228	4	breast	breast	NOUN
aiua-12464	228	5	cancer	cancer	NOUN
aiua-12464	228	6	in	in	ADP
aiua-12464	228	7	men	man	NOUN
aiua-12464	228	8	.	.	PUNCT
aiua-12464	229	1	n	n	PROPN
aiua-12464	229	2	engl	engl	PROPN
aiua-12464	229	3	j	j	PROPN
aiua-12464	229	4	med	med	PROPN
aiua-12464	229	5	.	.	PROPN
aiua-12464	229	6	2018	2018	NUM
aiua-12464	229	7	;	;	PUNCT
aiua-12464	229	8	378:2311	378:2311	NUM
aiua-12464	229	9	-	-	SYM
aiua-12464	229	10	20	20	NUM
aiua-12464	229	11	.	.	PUNCT
aiua-12464	230	1	21	21	NUM
aiua-12464	230	2	.	.	PUNCT
aiua-12464	231	1	flanagan	flanagan	PROPN
aiua-12464	231	2	se	se	PROPN
aiua-12464	231	3	,	,	PUNCT
aiua-12464	231	4	patch	patch	PROPN
aiua-12464	231	5	am	be	AUX
aiua-12464	231	6	,	,	PUNCT
aiua-12464	231	7	ellard	ellard	NOUN
aiua-12464	231	8	s.	s.	PROPN
aiua-12464	231	9	using	use	VERB
aiua-12464	231	10	sift	sift	NOUN
aiua-12464	231	11	and	and	CCONJ
aiua-12464	231	12	polyphen	polyphen	ADV
aiua-12464	231	13	to	to	PART
aiua-12464	231	14	predict	predict	VERB
aiua-12464	231	15	loss	loss	NOUN
aiua-12464	231	16	-	-	PUNCT
aiua-12464	231	17	of	of	ADP
aiua-12464	231	18	-	-	PUNCT
aiua-12464	231	19	function	function	NOUN
aiua-12464	231	20	and	and	CCONJ
aiua-12464	231	21	gain	gain	NOUN
aiua-12464	231	22	-	-	PUNCT
aiua-12464	231	23	of	of	ADP
aiua-12464	231	24	-	-	PUNCT
aiua-12464	231	25	function	function	NOUN
aiua-12464	231	26	mutations	mutation	NOUN
aiua-12464	231	27	.	.	PUNCT
aiua-12464	232	1	genet	genet	NOUN
aiua-12464	232	2	test	test	NOUN
aiua-12464	232	3	mol	mol	ADP
aiua-12464	232	4	biomarkers	biomarker	NOUN
aiua-12464	232	5	.	.	PUNCT
aiua-12464	233	1	2010	2010	NUM
aiua-12464	233	2	;	;	PUNCT
aiua-12464	233	3	14:533	14:533	NUM
aiua-12464	233	4	-	-	SYM
aiua-12464	233	5	7	7	NUM
aiua-12464	233	6	.	.	NOUN
aiua-12464	233	7	22	22	NUM
aiua-12464	233	8	.	.	PUNCT
aiua-12464	234	1	soegaard	soegaard	PROPN
aiua-12464	234	2	m	m	PROPN
aiua-12464	234	3	,	,	PUNCT
aiua-12464	234	4	kjaer	kjaer	NOUN
aiua-12464	234	5	sk	sk	VERB
aiua-12464	234	6	,	,	PUNCT
aiua-12464	234	7	cox	cox	PROPN
aiua-12464	234	8	m	m	PROPN
aiua-12464	234	9	,	,	PUNCT
aiua-12464	234	10	et	et	PROPN
aiua-12464	234	11	al	al	PROPN
aiua-12464	234	12	.	.	PROPN
aiua-12464	234	13	brca1	brca1	PROPN
aiua-12464	234	14	and	and	CCONJ
aiua-12464	234	15	brca2	brca2	PROPN
aiua-12464	234	16	mutation	mutation	NOUN
aiua-12464	234	17	prevalence	prevalence	NOUN
aiua-12464	234	18	and	and	CCONJ
aiua-12464	234	19	clinical	clinical	ADJ
aiua-12464	234	20	characteristics	characteristic	NOUN
aiua-12464	234	21	of	of	ADP
aiua-12464	234	22	a	a	DET
aiua-12464	234	23	population	population	NOUN
aiua-12464	234	24	-	-	PUNCT
aiua-12464	234	25	based	base	VERB
aiua-12464	234	26	series	series	NOUN
aiua-12464	234	27	of	of	ADP
aiua-12464	234	28	ovarian	ovarian	ADJ
aiua-12464	234	29	cancer	cancer	NOUN
aiua-12464	234	30	cases	case	NOUN
aiua-12464	234	31	from	from	ADP
aiua-12464	234	32	denmark	denmark	PROPN
aiua-12464	234	33	.	.	PUNCT
aiua-12464	235	1	clin	clin	PROPN
aiua-12464	235	2	cancer	cancer	NOUN
aiua-12464	235	3	res	re	NOUN
aiua-12464	235	4	.	.	PUNCT
aiua-12464	235	5	2008	2008	NUM
aiua-12464	235	6	;	;	PUNCT
aiua-12464	235	7	14:3761	14:3761	NUM
aiua-12464	235	8	-	-	SYM
aiua-12464	235	9	7	7	NUM
aiua-12464	235	10	.	.	NOUN
aiua-12464	235	11	23	23	NUM
aiua-12464	235	12	.	.	PUNCT
aiua-12464	236	1	adzhubei	adzhubei	NOUN
aiua-12464	236	2	i	i	PRON
aiua-12464	236	3	,	,	PUNCT
aiua-12464	236	4	jordan	jordan	PROPN
aiua-12464	236	5	dm	dm	PROPN
aiua-12464	236	6	,	,	PUNCT
aiua-12464	236	7	sunyaev	sunyaev	PROPN
aiua-12464	236	8	sr	sr	PROPN
aiua-12464	236	9	.	.	PUNCT
aiua-12464	237	1	predicting	predict	VERB
aiua-12464	237	2	functional	functional	ADJ
aiua-12464	237	3	effect	effect	NOUN
aiua-12464	237	4	of	of	ADP
aiua-12464	237	5	human	human	ADJ
aiua-12464	237	6	missense	missense	NOUN
aiua-12464	237	7	mutations	mutation	NOUN
aiua-12464	237	8	using	use	VERB
aiua-12464	237	9	polyphen-2	polyphen-2	NUM
aiua-12464	237	10	.	.	PUNCT
aiua-12464	238	1	curr	curr	PROPN
aiua-12464	238	2	protoc	protoc	VERB
aiua-12464	238	3	hum	hum	PROPN
aiua-12464	238	4	genet	genet	PROPN
aiua-12464	238	5	.	.	PUNCT
aiua-12464	239	1	2013	2013	NUM
aiua-12464	239	2	;	;	PUNCT
aiua-12464	239	3	chapter	chapter	NOUN
aiua-12464	239	4	7	7	NUM
aiua-12464	239	5	:	:	PUNCT
aiua-12464	239	6	unit7	unit7	NOUN
aiua-12464	239	7	20	20	NUM
aiua-12464	239	8	.	.	X
aiua-12464	239	9	24	24	NUM
aiua-12464	239	10	.	.	PUNCT
aiua-12464	240	1	pulumati	pulumati	PROPN
aiua-12464	240	2	a	a	PROPN
aiua-12464	240	3	,	,	PUNCT
aiua-12464	240	4	pulumati	pulumati	PROPN
aiua-12464	240	5	a	a	NOUN
aiua-12464	240	6	,	,	PUNCT
aiua-12464	240	7	dwarakanath	dwarakanath	NOUN
aiua-12464	240	8	bs	bs	PROPN
aiua-12464	240	9	,	,	PUNCT
aiua-12464	240	10	et	et	PROPN
aiua-12464	240	11	al	al	PROPN
aiua-12464	240	12	.	.	PUNCT
aiua-12464	240	13	technological	technological	ADJ
aiua-12464	240	14	advancements	advancement	NOUN
aiua-12464	240	15	in	in	ADP
aiua-12464	240	16	cancer	cancer	NOUN
aiua-12464	240	17	diagnostics	diagnostic	NOUN
aiua-12464	240	18	:	:	PUNCT
aiua-12464	240	19	improvements	improvement	NOUN
aiua-12464	240	20	and	and	CCONJ
aiua-12464	240	21	limitations	limitation	NOUN
aiua-12464	240	22	.	.	PUNCT
aiua-12464	241	1	cancer	cancer	NOUN
aiua-12464	241	2	rep	rep	PROPN
aiua-12464	241	3	(	(	PUNCT
aiua-12464	241	4	hoboken	hoboken	PROPN
aiua-12464	241	5	)	)	PUNCT
aiua-12464	241	6	.	.	PUNCT
aiua-12464	242	1	2023	2023	NUM
aiua-12464	242	2	;	;	PUNCT
aiua-12464	242	3	6	6	NUM
aiua-12464	242	4	:	:	PUNCT
aiua-12464	242	5	e1764	e1764	PROPN
aiua-12464	242	6	.	.	PROPN
aiua-12464	243	1	25	25	NUM
aiua-12464	243	2	.	.	PUNCT
aiua-12464	244	1	pires	pires	PROPN
aiua-12464	244	2	de	de	PROPN
aiua-12464	244	3	,	,	PUNCT
aiua-12464	244	4	ascher	ascher	PROPN
aiua-12464	244	5	db	db	PROPN
aiua-12464	244	6	,	,	PUNCT
aiua-12464	244	7	blundell	blundell	PROPN
aiua-12464	244	8	tl	tl	PROPN
aiua-12464	244	9	.	.	PUNCT
aiua-12464	245	1	mcsm	mcsm	PROPN
aiua-12464	245	2	:	:	PUNCT
aiua-12464	245	3	predicting	predict	VERB
aiua-12464	245	4	the	the	DET
aiua-12464	245	5	effects	effect	NOUN
aiua-12464	245	6	of	of	ADP
aiua-12464	245	7	mutations	mutation	NOUN
aiua-12464	245	8	in	in	ADP
aiua-12464	245	9	proteins	protein	NOUN
aiua-12464	245	10	using	use	VERB
aiua-12464	245	11	graph	graph	NOUN
aiua-12464	245	12	-	-	PUNCT
aiua-12464	245	13	based	base	VERB
aiua-12464	245	14	signatures	signature	NOUN
aiua-12464	245	15	.	.	PUNCT
aiua-12464	246	1	bioinformatics	bioinformatics	NOUN
aiua-12464	246	2	.	.	PUNCT
aiua-12464	246	3	2014	2014	NUM
aiua-12464	246	4	;	;	PUNCT
aiua-12464	246	5	30:335	30:335	NUM
aiua-12464	246	6	-	-	SYM
aiua-12464	246	7	42	42	NUM
aiua-12464	246	8	.	.	PUNCT
aiua-12464	247	1	26	26	NUM
aiua-12464	247	2	.	.	PUNCT
aiua-12464	248	1	lewis	lewis	PROPN
aiua-12464	248	2	ha	ha	PROPN
aiua-12464	248	3	,	,	PUNCT
aiua-12464	248	4	zhao	zhao	PROPN
aiua-12464	248	5	x	x	PROPN
aiua-12464	248	6	,	,	PUNCT
aiua-12464	248	7	wang	wang	PROPN
aiua-12464	248	8	c	c	AUX
aiua-12464	248	9	,	,	PUNCT
aiua-12464	248	10	et	et	PROPN
aiua-12464	248	11	al	al	PROPN
aiua-12464	248	12	.	.	PROPN
aiua-12464	248	13	impact	impact	NOUN
aiua-12464	248	14	of	of	ADP
aiua-12464	248	15	the	the	DET
aiua-12464	248	16	deltaf508	deltaf508	PROPN
aiua-12464	248	17	mutation	mutation	NOUN
aiua-12464	248	18	in	in	ADP
aiua-12464	248	19	first	first	ADJ
aiua-12464	248	20	nucleotide	nucleotide	NOUN
aiua-12464	248	21	-	-	PUNCT
aiua-12464	248	22	binding	bind	VERB
aiua-12464	248	23	domain	domain	NOUN
aiua-12464	248	24	of	of	ADP
aiua-12464	248	25	human	human	ADJ
aiua-12464	248	26	cystic	cystic	ADJ
aiua-12464	248	27	fibrosis	fibrosis	NOUN
aiua-12464	248	28	transmembrane	transmembrane	NOUN
aiua-12464	248	29	conductance	conductance	NOUN
aiua-12464	248	30	regulator	regulator	NOUN
aiua-12464	248	31	on	on	ADP
aiua-12464	248	32	domain	domain	NOUN
aiua-12464	248	33	folding	folding	NOUN
aiua-12464	248	34	and	and	CCONJ
aiua-12464	248	35	structure	structure	NOUN
aiua-12464	248	36	.	.	PUNCT
aiua-12464	249	1	j	j	PROPN
aiua-12464	249	2	biol	biol	PROPN
aiua-12464	249	3	chem	chem	NOUN
aiua-12464	249	4	.	.	PUNCT
aiua-12464	250	1	2005	2005	NUM
aiua-12464	250	2	;	;	PUNCT
aiua-12464	250	3	280:1346	280:1346	NUM
aiua-12464	250	4	-	-	SYM
aiua-12464	250	5	53	53	NUM
aiua-12464	250	6	.	.	PUNCT
aiua-12464	251	1	27	27	NUM
aiua-12464	251	2	.	.	PUNCT
aiua-12464	252	1	ehrhardt	ehrhardt	PROPN
aiua-12464	252	2	a	a	PROPN
aiua-12464	252	3	,	,	PUNCT
aiua-12464	252	4	chung	chung	PROPN
aiua-12464	252	5	wj	wj	PROPN
aiua-12464	252	6	,	,	PUNCT
aiua-12464	252	7	pyle	pyle	PROPN
aiua-12464	252	8	lc	lc	PROPN
aiua-12464	252	9	,	,	PUNCT
aiua-12464	252	10	et	et	PROPN
aiua-12464	252	11	al	al	PROPN
aiua-12464	252	12	.	.	PROPN
aiua-12464	252	13	channel	channel	PROPN
aiua-12464	252	14	gating	gate	VERB
aiua-12464	252	15	regulation	regulation	NOUN
aiua-12464	252	16	by	by	ADP
aiua-12464	252	17	the	the	DET
aiua-12464	252	18	cystic	cystic	ADJ
aiua-12464	252	19	fibrosis	fibrosis	NOUN
aiua-12464	252	20	transmembrane	transmembrane	NOUN
aiua-12464	252	21	conductance	conductance	NOUN
aiua-12464	252	22	regulator	regulator	NOUN
aiua-12464	252	23	(	(	PUNCT
aiua-12464	252	24	cftr	cftr	NOUN
aiua-12464	252	25	)	)	PUNCT
aiua-12464	252	26	first	first	ADJ
aiua-12464	252	27	cytosolic	cytosolic	ADJ
aiua-12464	252	28	loop	loop	NOUN
aiua-12464	252	29	.	.	PUNCT
aiua-12464	253	1	j	j	PROPN
aiua-12464	253	2	biol	biol	PROPN
aiua-12464	253	3	chem	chem	NOUN
aiua-12464	253	4	.	.	PUNCT
aiua-12464	254	1	2016	2016	NUM
aiua-12464	254	2	;	;	PUNCT
aiua-12464	254	3	291:1854	291:1854	NUM
aiua-12464	254	4	-	-	SYM
aiua-12464	254	5	65	65	NUM
aiua-12464	254	6	.	.	PUNCT
aiua-12464	255	1	28	28	NUM
aiua-12464	255	2	.	.	PUNCT
aiua-12464	256	1	uppaluri	uppaluri	PROPN
aiua-12464	256	2	l	l	PROPN
aiua-12464	256	3	,	,	PUNCT
aiua-12464	256	4	england	england	PROPN
aiua-12464	256	5	s	s	PART
aiua-12464	256	6	,	,	PUNCT
aiua-12464	256	7	scanlin	scanlin	NOUN
aiua-12464	256	8	t.	t.	PROPN
aiua-12464	256	9	clinical	clinical	ADJ
aiua-12464	256	10	evidence	evidence	NOUN
aiua-12464	256	11	that	that	PRON
aiua-12464	256	12	v456a	v456a	PROPN
aiua-12464	256	13	is	be	AUX
aiua-12464	256	14	a	a	DET
aiua-12464	256	15	cystic	cystic	ADJ
aiua-12464	256	16	fibrosis	fibrosis	NOUN
aiua-12464	256	17	causing	cause	VERB
aiua-12464	256	18	mutation	mutation	NOUN
aiua-12464	256	19	in	in	ADP
aiua-12464	256	20	south	south	PROPN
aiua-12464	256	21	asians	asians	PROPN
aiua-12464	256	22	.	.	PUNCT
aiua-12464	257	1	journal	journal	PROPN
aiua-12464	257	2	of	of	ADP
aiua-12464	257	3	cystic	cystic	ADJ
aiua-12464	257	4	fibrosis	fibrosis	NOUN
aiua-12464	257	5	.	.	PUNCT
aiua-12464	258	1	2012	2012	NUM
aiua-12464	258	2	;	;	PUNCT
aiua-12464	258	3	11:312	11:312	NUM
aiua-12464	258	4	-	-	SYM
aiua-12464	258	5	5	5	NUM
aiua-12464	258	6	.	.	NOUN
aiua-12464	258	7	29	29	NUM
aiua-12464	258	8	.	.	PUNCT
aiua-12464	259	1	ziedalski	ziedalski	PROPN
aiua-12464	259	2	tm	tm	PROPN
aiua-12464	259	3	,	,	PUNCT
aiua-12464	259	4	kao	kao	PROPN
aiua-12464	259	5	pn	pn	PROPN
aiua-12464	259	6	,	,	PUNCT
aiua-12464	259	7	henig	henig	PROPN
aiua-12464	259	8	nr	nr	PROPN
aiua-12464	259	9	,	,	PUNCT
aiua-12464	259	10	et	et	PROPN
aiua-12464	259	11	al	al	PROPN
aiua-12464	259	12	.	.	PROPN
aiua-12464	259	13	prospective	prospective	ADJ
aiua-12464	259	14	analysis	analysis	NOUN
aiua-12464	259	15	of	of	ADP
aiua-12464	259	16	cystic	cystic	ADJ
aiua-12464	259	17	fibrosis	fibrosis	NOUN
aiua-12464	259	18	transmembrane	transmembrane	NOUN
aiua-12464	259	19	regulator	regulator	NOUN
aiua-12464	259	20	mutations	mutation	NOUN
aiua-12464	259	21	in	in	ADP
aiua-12464	259	22	adults	adult	NOUN
aiua-12464	259	23	with	with	ADP
aiua-12464	259	24	bronchiectasis	bronchiectasis	NOUN
aiua-12464	259	25	or	or	CCONJ
aiua-12464	259	26	pulmonary	pulmonary	ADJ
aiua-12464	259	27	nontuberculous	nontuberculous	ADJ
aiua-12464	259	28	mycobacterial	mycobacterial	ADJ
aiua-12464	259	29	infection	infection	NOUN
aiua-12464	259	30	.	.	PUNCT
aiua-12464	260	1	chest	chest	NOUN
aiua-12464	260	2	.	.	PUNCT
aiua-12464	261	1	2006	2006	NUM
aiua-12464	261	2	;	;	PUNCT
aiua-12464	261	3	130:995	130:995	NUM
aiua-12464	261	4	-	-	PUNCT
aiua-12464	261	5	1002	1002	NUM
aiua-12464	261	6	.	.	PUNCT
aiua-12464	262	1	30	30	NUM
aiua-12464	262	2	.	.	PUNCT
aiua-12464	263	1	mccormick	mccormick	PROPN
aiua-12464	263	2	j	j	PROPN
aiua-12464	263	3	,	,	PUNCT
aiua-12464	263	4	green	green	PROPN
aiua-12464	263	5	mw	mw	PROPN
aiua-12464	263	6	,	,	PUNCT
aiua-12464	263	7	mehta	mehta	PROPN
aiua-12464	263	8	g	g	PROPN
aiua-12464	263	9	,	,	PUNCT
aiua-12464	263	10	et	et	PROPN
aiua-12464	263	11	al	al	PROPN
aiua-12464	263	12	.	.	PUNCT
aiua-12464	264	1	demographics	demographic	NOUN
aiua-12464	264	2	of	of	ADP
aiua-12464	264	3	the	the	DET
aiua-12464	264	4	uk	uk	PROPN
aiua-12464	264	5	cystic	cystic	ADJ
aiua-12464	264	6	fibrosis	fibrosis	NOUN
aiua-12464	264	7	population	population	NOUN
aiua-12464	264	8	:	:	PUNCT
aiua-12464	264	9	implications	implication	NOUN
aiua-12464	264	10	for	for	ADP
aiua-12464	264	11	neonatal	neonatal	ADJ
aiua-12464	264	12	screening	screening	NOUN
aiua-12464	264	13	.	.	PUNCT
aiua-12464	265	1	eur	eur	PROPN
aiua-12464	265	2	j	j	PROPN
aiua-12464	265	3	hum	hum	PROPN
aiua-12464	265	4	genet	genet	PROPN
aiua-12464	265	5	.	.	PUNCT
aiua-12464	266	1	2002	2002	NUM
aiua-12464	266	2	;	;	PUNCT
aiua-12464	266	3	10:583	10:583	NUM
aiua-12464	266	4	-	-	SYM
aiua-12464	266	5	90	90	NUM
aiua-12464	266	6	.	.	PUNCT
aiua-12464	267	1	31	31	NUM
aiua-12464	267	2	.	.	PUNCT
aiua-12464	268	1	tsui	tsui	PROPN
aiua-12464	268	2	lc	lc	PROPN
aiua-12464	268	3	,	,	PUNCT
aiua-12464	268	4	dorfman	dorfman	PROPN
aiua-12464	268	5	r.	r.	PROPN
aiua-12464	268	6	the	the	DET
aiua-12464	268	7	cystic	cystic	ADJ
aiua-12464	268	8	fibrosis	fibrosis	NOUN
aiua-12464	268	9	gene	gene	NOUN
aiua-12464	268	10	:	:	PUNCT
aiua-12464	268	11	a	a	DET
aiua-12464	268	12	molecular	molecular	ADJ
aiua-12464	268	13	genetic	genetic	ADJ
aiua-12464	268	14	perspective	perspective	NOUN
aiua-12464	268	15	.	.	PUNCT
aiua-12464	269	1	cold	cold	ADJ
aiua-12464	269	2	spring	spring	NOUN
aiua-12464	269	3	harb	harb	PROPN
aiua-12464	269	4	perspect	perspect	PROPN
aiua-12464	269	5	med	med	PROPN
aiua-12464	269	6	.	.	PUNCT
aiua-12464	269	7	2013	2013	NUM
aiua-12464	269	8	;	;	PUNCT
aiua-12464	270	1	3	3	NUM
aiua-12464	270	2	:	:	PUNCT
aiua-12464	270	3	a009472	a009472	PROPN
aiua-12464	270	4	.	.	PUNCT
aiua-12464	271	1	32	32	NUM
aiua-12464	271	2	.	.	PUNCT
aiua-12464	271	3	lukacs	lukacs	PROPN
aiua-12464	271	4	gl	gl	PROPN
aiua-12464	271	5	,	,	PUNCT
aiua-12464	271	6	verkman	verkman	NOUN
aiua-12464	271	7	as	as	ADP
aiua-12464	271	8	.	.	PUNCT
aiua-12464	272	1	cftr	cftr	PROPN
aiua-12464	272	2	:	:	PUNCT
aiua-12464	272	3	folding	folding	NOUN
aiua-12464	272	4	,	,	PUNCT
aiua-12464	272	5	misfolding	misfolde	VERB
aiua-12464	272	6	and	and	CCONJ
aiua-12464	272	7	correcting	correct	VERB
aiua-12464	272	8	the	the	DET
aiua-12464	272	9	deltaf508	deltaf508	PROPN
aiua-12464	272	10	conformational	conformational	ADJ
aiua-12464	272	11	defect	defect	NOUN
aiua-12464	272	12	.	.	PUNCT
aiua-12464	273	1	trends	trend	NOUN
aiua-12464	273	2	mol	mol	ADP
aiua-12464	273	3	med	med	PROPN
aiua-12464	273	4	.	.	PUNCT
aiua-12464	273	5	2012	2012	NUM
aiua-12464	273	6	;	;	PUNCT
aiua-12464	273	7	18:81	18:81	NUM
aiua-12464	273	8	-	-	SYM
aiua-12464	273	9	91	91	NUM
aiua-12464	273	10	.	.	PUNCT
aiua-12464	274	1	33	33	NUM
aiua-12464	274	2	.	.	PUNCT
aiua-12464	275	1	veit	veit	PROPN
aiua-12464	275	2	g	g	PROPN
aiua-12464	275	3	,	,	PUNCT
aiua-12464	275	4	avramescu	avramescu	PROPN
aiua-12464	275	5	rg	rg	PROPN
aiua-12464	275	6	,	,	PUNCT
aiua-12464	275	7	chiang	chiang	PROPN
aiua-12464	275	8	an	an	PROPN
aiua-12464	275	9	,	,	PUNCT
aiua-12464	275	10	et	et	PROPN
aiua-12464	275	11	al	al	PROPN
aiua-12464	275	12	.	.	PROPN
aiua-12464	276	1	from	from	ADP
aiua-12464	276	2	cftr	cftr	PROPN
aiua-12464	276	3	biology	biology	NOUN
aiua-12464	276	4	toward	toward	ADP
aiua-12464	276	5	combinatorial	combinatorial	ADJ
aiua-12464	276	6	pharmacotherapy	pharmacotherapy	NOUN
aiua-12464	276	7	:	:	PUNCT
aiua-12464	276	8	expanded	expand	VERB
aiua-12464	276	9	classification	classification	NOUN
aiua-12464	276	10	of	of	ADP
aiua-12464	276	11	cystic	cystic	ADJ
aiua-12464	276	12	fibrosis	fibrosis	NOUN
aiua-12464	276	13	mutations	mutation	NOUN
aiua-12464	276	14	.	.	PUNCT
aiua-12464	277	1	mol	mol	ADP
aiua-12464	277	2	biol	biol	ADJ
aiua-12464	277	3	cell	cell	NOUN
aiua-12464	277	4	.	.	PUNCT
aiua-12464	278	1	2016	2016	NUM
aiua-12464	278	2	;	;	PUNCT
aiua-12464	278	3	27:424	27:424	NUM
aiua-12464	278	4	-	-	SYM
aiua-12464	278	5	33	33	NUM
aiua-12464	278	6	.	.	PUNCT
aiua-12464	279	1	34	34	NUM
aiua-12464	279	2	.	.	PUNCT
aiua-12464	280	1	lakshminarayan	lakshminarayan	PROPN
aiua-12464	280	2	r	r	PROPN
aiua-12464	280	3	,	,	PUNCT
aiua-12464	280	4	phillips	phillips	PROPN
aiua-12464	280	5	bp	bp	PROPN
aiua-12464	280	6	,	,	PUNCT
aiua-12464	280	7	binnian	binnian	PROPN
aiua-12464	280	8	il	il	PROPN
aiua-12464	280	9	,	,	PUNCT
aiua-12464	280	10	et	et	PROPN
aiua-12464	280	11	al	al	PROPN
aiua-12464	280	12	.	.	PUNCT
aiua-12464	281	1	pre	pre	ADJ
aiua-12464	281	2	-	-	ADJ
aiua-12464	281	3	emptive	emptive	ADJ
aiua-12464	281	4	quality	quality	NOUN
aiua-12464	281	5	control	control	NOUN
aiua-12464	281	6	of	of	ADP
aiua-12464	281	7	a	a	DET
aiua-12464	281	8	misfolded	misfolded	ADJ
aiua-12464	281	9	membrane	membrane	NOUN
aiua-12464	281	10	protein	protein	NOUN
aiua-12464	281	11	by	by	ADP
aiua-12464	281	12	ribosome	ribosome	NOUN
aiua-12464	281	13	-	-	PUNCT
aiua-12464	281	14	driven	drive	VERB
aiua-12464	281	15	effects	effect	NOUN
aiua-12464	281	16	.	.	PUNCT
aiua-12464	282	1	curr	curr	PROPN
aiua-12464	282	2	biol	biol	PROPN
aiua-12464	282	3	.	.	PUNCT
aiua-12464	283	1	2020	2020	NUM
aiua-12464	283	2	;	;	PUNCT
aiua-12464	283	3	30:854	30:854	NUM
aiua-12464	283	4	-	-	SYM
aiua-12464	283	5	64	64	NUM
aiua-12464	283	6	e5	e5	NOUN
aiua-12464	283	7	.	.	PUNCT
aiua-12464	284	1	35	35	NUM
aiua-12464	284	2	.	.	PUNCT
aiua-12464	285	1	ikuma	ikuma	PROPN
aiua-12464	285	2	m	m	PROPN
aiua-12464	285	3	,	,	PUNCT
aiua-12464	285	4	welsh	welsh	PROPN
aiua-12464	285	5	mj	mj	PROPN
aiua-12464	285	6	.	.	PROPN
aiua-12464	285	7	regulation	regulation	NOUN
aiua-12464	285	8	of	of	ADP
aiua-12464	285	9	cftr	cftr	PROPN
aiua-12464	285	10	clchannel	clchannel	NOUN
aiua-12464	285	11	gating	gate	VERB
aiua-12464	285	12	by	by	ADP
aiua-12464	285	13	atp	atp	NOUN
aiua-12464	285	14	binding	bind	VERB
aiua-12464	285	15	and	and	CCONJ
aiua-12464	285	16	hydrolysis	hydrolysis	NOUN
aiua-12464	285	17	.	.	PUNCT
aiua-12464	286	1	proc	proc	PROPN
aiua-12464	286	2	natl	natl	PROPN
aiua-12464	286	3	acad	acad	PROPN
aiua-12464	286	4	sci	sci	PROPN
aiua-12464	286	5	usa	usa	PROPN
aiua-12464	286	6	.	.	PROPN
aiua-12464	286	7	2000	2000	NUM
aiua-12464	286	8	;	;	PUNCT
aiua-12464	287	1	97:8675	97:8675	X
aiua-12464	287	2	-	-	SYM
aiua-12464	287	3	80	80	NUM
aiua-12464	287	4	.	.	PUNCT
aiua-12464	288	1	correspondence	correspondence	NOUN
aiua-12464	288	2	khush	khush	PROPN
aiua-12464	288	3	bakhat	bakhat	PROPN
aiua-12464	289	1	khushbkht@gmail.com	khushbkht@gmail.com	PROPN
aiua-12464	290	1	kanwal	kanwal	PROPN
aiua-12464	290	2	anwar	anwar	PROPN
aiua-12464	290	3	kanwalanwar14@gmail.com	kanwalanwar14@gmail.com	PROPN
aiua-12464	290	4	sadaf	sadaf	NOUN
aiua-12464	290	5	sarfraz	sarfraz	PROPN
aiua-12464	290	6	sadafsarfraz.40@gmail.com	sadafsarfraz.40@gmail.com	PROPN
aiua-12464	290	7	sheza	sheza	PROPN
aiua-12464	290	8	javaid	javaid	PROPN
aiua-12464	290	9	shezajavaid930@gmail.com	shezajavaid930@gmail.com	PROPN
aiua-12464	290	10	adnan	adnan	PROPN
aiua-12464	290	11	arshad	arshad	PROPN
aiua-12464	290	12	adnanarshad@fccollege.edu.pk	adnanarshad@fccollege.edu.pk	PROPN
aiua-12464	290	13	kam	kam	PROPN
aiua-12464	290	14	school	school	NOUN
aiua-12464	290	15	of	of	ADP
aiua-12464	290	16	life	life	NOUN
aiua-12464	290	17	science	science	NOUN
aiua-12464	290	18	,	,	PUNCT
aiua-12464	290	19	forman	forman	PROPN
aiua-12464	290	20	christian	christian	PROPN
aiua-12464	290	21	college	college	PROPN
aiua-12464	290	22	,	,	PUNCT
aiua-12464	290	23	(	(	PUNCT
aiua-12464	290	24	a	a	DET
aiua-12464	290	25	chartered	chartered	ADJ
aiua-12464	290	26	university	university	NOUN
aiua-12464	290	27	)	)	PUNCT
aiua-12464	290	28	,	,	PUNCT
aiua-12464	290	29	lahore	lahore	PROPN
aiua-12464	290	30	,	,	PUNCT
aiua-12464	290	31	pakistan	pakistan	PROPN
aiua-12464	290	32	muhammad	muhammad	PROPN
aiua-12464	290	33	mustafa	mustafa	PROPN
aiua-12464	290	34	(	(	PUNCT
aiua-12464	290	35	corresponding	corresponding	ADJ
aiua-12464	290	36	author	author	NOUN
aiua-12464	290	37	)	)	PUNCT
aiua-12464	290	38	muhammadmustafa@fccollege.edu.pk	muhammadmustafa@fccollege.edu.pk	VERB
aiua-12464	290	39	kam	kam	ADJ
aiua-12464	290	40	school	school	NOUN
aiua-12464	290	41	of	of	ADP
aiua-12464	290	42	life	life	NOUN
aiua-12464	290	43	science	science	NOUN
aiua-12464	290	44	,	,	PUNCT
aiua-12464	290	45	s346	s346	PROPN
aiua-12464	290	46	armacost	armacost	VERB
aiua-12464	290	47	science	science	NOUN
aiua-12464	290	48	building	building	NOUN
aiua-12464	290	49	,	,	PUNCT
aiua-12464	290	50	ferozepur	ferozepur	NOUN
aiua-12464	290	51	road	road	NOUN
aiua-12464	290	52	,	,	PUNCT
aiua-12464	290	53	lahore	lahore	PROPN
aiua-12464	290	54	54600	54600	NUM
aiua-12464	290	55	,	,	PUNCT
aiua-12464	290	56	pakistan	pakistan	PROPN
aiua-12464	290	57	irsa	irsa	PROPN
aiua-12464	290	58	mateen	mateen	PROPN
aiua-12464	291	1	irsamateen.biochem@mul.edu.pk	irsamateen.biochem@mul.edu.pk	ADP
aiua-12464	291	2	school	school	NOUN
aiua-12464	291	3	of	of	ADP
aiua-12464	291	4	biochemistry	biochemistry	NOUN
aiua-12464	291	5	,	,	PUNCT
aiua-12464	291	6	minhaj	minhaj	PROPN
aiua-12464	291	7	university	university	PROPN
aiua-12464	291	8	lahore	lahore	NOUN
aiua-12464	291	9	,	,	PUNCT
aiua-12464	291	10	lahore	lahore	PROPN
aiua-12464	291	11	,	,	PUNCT
aiua-12464	291	12	pakistan	pakistan	PROPN
aiua-12464	291	13	hina	hina	PROPN
aiua-12464	291	14	saif	saif	PROPN
aiua-12464	291	15	hina.saif@deaht.uol.edu.pk	hina.saif@deaht.uol.edu.pk	PROPN
aiua-12464	291	16	department	department	NOUN
aiua-12464	291	17	of	of	ADP
aiua-12464	291	18	emerging	emerge	VERB
aiua-12464	291	19	allied	ally	VERB
aiua-12464	291	20	health	health	NOUN
aiua-12464	291	21	technologies	technology	NOUN
aiua-12464	291	22	,	,	PUNCT
aiua-12464	291	23	university	university	NOUN
aiua-12464	291	24	of	of	ADP
aiua-12464	291	25	lahore	lahore	PROPN
aiua-12464	291	26	,	,	PUNCT
aiua-12464	291	27	pakistan	pakistan	PROPN
aiua-12464	291	28	khaleeq	khaleeq	PROPN
aiua-12464	291	29	-	-	PUNCT
aiua-12464	291	30	ur	ur	INTJ
aiua-12464	291	31	-	-	ADJ
aiua-12464	291	32	rehman	rehman	ADJ
aiua-12464	291	33	khaleeqr@hotmail.com	khaleeqr@hotmail.com	PROPN
aiua-12464	291	34	department	department	PROPN
aiua-12464	291	35	of	of	ADP
aiua-12464	291	36	urology	urology	NOUN
aiua-12464	291	37	,	,	PUNCT
aiua-12464	291	38	fatima	fatima	PROPN
aiua-12464	291	39	memorial	memorial	PROPN
aiua-12464	291	40	hospital	hospital	PROPN
aiua-12464	291	41	college	college	PROPN
aiua-12464	291	42	of	of	ADP
aiua-12464	291	43	medicine	medicine	PROPN
aiua-12464	291	44	&	&	CCONJ
aiua-12464	291	45	dentistry	dentistry	PROPN
aiua-12464	291	46	,	,	PUNCT
aiua-12464	291	47	lahore	lahore	PROPN
aiua-12464	291	48	,	,	PUNCT
aiua-12464	291	49	pakistan	pakistan	ADJ
aiua-12464	291	50	conflict	conflict	NOUN
aiua-12464	291	51	of	of	ADP
aiua-12464	291	52	interest	interest	NOUN
aiua-12464	291	53	:	:	PUNCT
aiua-12464	291	54	the	the	DET
aiua-12464	291	55	authors	author	NOUN
aiua-12464	291	56	declare	declare	VERB
aiua-12464	291	57	no	no	DET
aiua-12464	291	58	potential	potential	ADJ
aiua-12464	291	59	conflict	conflict	NOUN
aiua-12464	291	60	of	of	ADP
aiua-12464	291	61	interest	interest	NOUN
aiua-12464	291	62	.	.	PUNCT