id	sid	tid	token	lemma	pos
aiua-13277	1	1	stesura	stesura	PROPN
aiua-13277	1	2	seveso	seveso	PROPN
aiua-13277	1	3	archivio	archivio	PROPN
aiua-13277	1	4	italiano	italiano	X
aiua-13277	1	5	di	di	X
aiua-13277	1	6	urologia	urologia	PROPN
aiua-13277	1	7	e	e	PROPN
aiua-13277	1	8	andrologia	andrologia	NOUN
aiua-13277	1	9	2024	2024	NUM
aiua-13277	1	10	;	;	PUNCT
aiua-13277	1	11	96(4):13277	96(4):13277	NUM
aiua-13277	1	12	1	1	NUM
aiua-13277	1	13	review	review	VERB
aiua-13277	1	14	the	the	DET
aiua-13277	1	15	elimination	elimination	NOUN
aiua-13277	1	16	half	half	ADJ
aiua-13277	1	17	-	-	PUNCT
aiua-13277	1	18	life	life	NOUN
aiua-13277	1	19	of	of	ADP
aiua-13277	1	20	theobromine	theobromine	NOUN
aiua-13277	1	21	is	be	AUX
aiua-13277	1	22	between	between	ADP
aiua-13277	1	23	6	6	NUM
aiua-13277	1	24	and	and	CCONJ
aiua-13277	1	25	8	8	NUM
aiua-13277	1	26	hours	hour	NOUN
aiua-13277	1	27	.	.	PUNCT
aiua-13277	2	1	the	the	DET
aiua-13277	2	2	primary	primary	ADJ
aiua-13277	2	3	metabolites	metabolite	NOUN
aiua-13277	2	4	of	of	ADP
aiua-13277	2	5	theobromine	theobromine	NOUN
aiua-13277	2	6	are	be	AUX
aiua-13277	2	7	3	3	NUM
aiua-13277	2	8	-	-	PUNCT
aiua-13277	2	9	methylxantine	methylxantine	NOUN
aiua-13277	2	10	,	,	PUNCT
aiua-13277	2	11	7	7	NUM
aiua-13277	2	12	-	-	PUNCT
aiua-13277	2	13	methylxantine	methylxantine	NOUN
aiua-13277	2	14	,	,	PUNCT
aiua-13277	2	15	7	7	NUM
aiua-13277	2	16	-	-	PUNCT
aiua-13277	2	17	methyluric	methyluric	ADJ
aiua-13277	2	18	acid	acid	NOUN
aiua-13277	2	19	and	and	CCONJ
aiua-13277	2	20	3,7	3,7	NUM
aiua-13277	2	21	-	-	PUNCT
aiua-13277	2	22	dimethyluric	dimethyluric	ADJ
aiua-13277	2	23	acid	acid	NOUN
aiua-13277	2	24	,	,	PUNCT
aiua-13277	2	25	with	with	ADP
aiua-13277	2	26	18	18	NUM
aiua-13277	2	27	-	-	SYM
aiua-13277	2	28	21	21	NUM
aiua-13277	2	29	%	%	NOUN
aiua-13277	2	30	of	of	ADP
aiua-13277	2	31	theobromine	theobromine	NOUN
aiua-13277	2	32	excreted	excrete	VERB
aiua-13277	2	33	unchanged	unchanged	ADJ
aiua-13277	2	34	in	in	ADP
aiua-13277	2	35	the	the	DET
aiua-13277	2	36	urine	urine	NOUN
aiua-13277	2	37	(	(	PUNCT
aiua-13277	2	38	3	3	NUM
aiua-13277	2	39	-	-	SYM
aiua-13277	2	40	5	5	NUM
aiua-13277	2	41	)	)	PUNCT
aiua-13277	2	42	.	.	PUNCT
aiua-13277	3	1	theobromine	theobromine	NOUN
aiua-13277	3	2	also	also	ADV
aiua-13277	3	3	derives	derive	VERB
aiua-13277	3	4	from	from	ADP
aiua-13277	3	5	caffeine	caffeine	NOUN
aiua-13277	3	6	that	that	PRON
aiua-13277	3	7	is	be	AUX
aiua-13277	3	8	metabolized	metabolize	VERB
aiua-13277	3	9	in	in	ADP
aiua-13277	3	10	the	the	DET
aiua-13277	3	11	liver	liver	NOUN
aiua-13277	3	12	into	into	ADP
aiua-13277	3	13	paraxanthine	paraxanthine	NOUN
aiua-13277	3	14	(	(	PUNCT
aiua-13277	3	15	84	84	NUM
aiua-13277	3	16	%	%	NOUN
aiua-13277	3	17	)	)	PUNCT
aiua-13277	3	18	,	,	PUNCT
aiua-13277	3	19	theobromine	theobromine	NOUN
aiua-13277	3	20	(	(	PUNCT
aiua-13277	3	21	12	12	NUM
aiua-13277	3	22	%	%	NOUN
aiua-13277	3	23	)	)	PUNCT
aiua-13277	3	24	,	,	PUNCT
aiua-13277	3	25	and	and	CCONJ
aiua-13277	3	26	theophylline	theophylline	NOUN
aiua-13277	3	27	(	(	PUNCT
aiua-13277	3	28	4	4	NUM
aiua-13277	3	29	%	%	NOUN
aiua-13277	3	30	)	)	PUNCT
aiua-13277	3	31	.	.	PUNCT
aiua-13277	4	1	for	for	ADP
aiua-13277	4	2	this	this	DET
aiua-13277	4	3	reason	reason	NOUN
aiua-13277	4	4	,	,	PUNCT
aiua-13277	4	5	individuals	individual	NOUN
aiua-13277	4	6	that	that	PRON
aiua-13277	4	7	non	non	X
aiua-13277	4	8	ingest	ingest	VERB
aiua-13277	4	9	theobromine	theobromine	NOUN
aiua-13277	4	10	(	(	PUNCT
aiua-13277	4	11	or	or	CCONJ
aiua-13277	4	12	chocolate	chocolate	NOUN
aiua-13277	4	13	)	)	PUNCT
aiua-13277	4	14	could	could	AUX
aiua-13277	4	15	have	have	VERB
aiua-13277	4	16	low	low	ADJ
aiua-13277	4	17	,	,	PUNCT
aiua-13277	4	18	though	though	SCONJ
aiua-13277	4	19	detectable	detectable	ADJ
aiua-13277	4	20	,	,	PUNCT
aiua-13277	4	21	urinary	urinary	ADJ
aiua-13277	4	22	levels	level	NOUN
aiua-13277	4	23	of	of	ADP
aiua-13277	4	24	theobromine	theobromine	NOUN
aiua-13277	4	25	(	(	PUNCT
aiua-13277	4	26	6	6	NUM
aiua-13277	4	27	,	,	PUNCT
aiua-13277	4	28	7	7	NUM
aiua-13277	4	29	)	)	PUNCT
aiua-13277	4	30	.	.	PUNCT
aiua-13277	5	1	theobromine	theobromine	NOUN
aiua-13277	5	2	has	have	AUX
aiua-13277	5	3	stimulating	stimulate	VERB
aiua-13277	5	4	action	action	NOUN
aiua-13277	5	5	on	on	ADP
aiua-13277	5	6	the	the	DET
aiua-13277	5	7	central	central	ADJ
aiua-13277	5	8	nervous	nervous	ADJ
aiua-13277	5	9	system	system	NOUN
aiua-13277	5	10	by	by	ADP
aiua-13277	5	11	intervening	intervene	VERB
aiua-13277	5	12	on	on	ADP
aiua-13277	5	13	the	the	DET
aiua-13277	5	14	synapses	synapsis	NOUN
aiua-13277	5	15	,	,	PUNCT
aiua-13277	5	16	but	but	CCONJ
aiua-13277	5	17	this	this	DET
aiua-13277	5	18	effect	effect	NOUN
aiua-13277	5	19	is	be	AUX
aiua-13277	5	20	weaker	weak	ADJ
aiua-13277	5	21	than	than	ADP
aiua-13277	5	22	caffeine	caffeine	NOUN
aiua-13277	5	23	(	(	PUNCT
aiua-13277	5	24	8)	8)	NUM
aiua-13277	5	25	.	.	PUNCT
aiua-13277	6	1	it	it	PRON
aiua-13277	6	2	has	have	VERB
aiua-13277	6	3	negligible	negligible	ADJ
aiua-13277	6	4	toxicity	toxicity	NOUN
aiua-13277	6	5	in	in	ADP
aiua-13277	6	6	humans	human	NOUN
aiua-13277	6	7	,	,	PUNCT
aiua-13277	6	8	because	because	SCONJ
aiua-13277	6	9	it	it	PRON
aiua-13277	6	10	is	be	AUX
aiua-13277	6	11	metabolized	metabolize	VERB
aiua-13277	6	12	very	very	ADV
aiua-13277	6	13	quickly	quickly	ADV
aiua-13277	6	14	.	.	PUNCT
aiua-13277	7	1	in	in	ADP
aiua-13277	7	2	other	other	ADJ
aiua-13277	7	3	mammals	mammal	NOUN
aiua-13277	7	4	,	,	PUNCT
aiua-13277	7	5	such	such	ADJ
aiua-13277	7	6	as	as	ADP
aiua-13277	7	7	dogs	dog	NOUN
aiua-13277	7	8	and	and	CCONJ
aiua-13277	7	9	cats	cat	NOUN
aiua-13277	7	10	,	,	PUNCT
aiua-13277	7	11	it	it	PRON
aiua-13277	7	12	becomes	become	VERB
aiua-13277	7	13	toxic	toxic	ADJ
aiua-13277	7	14	because	because	SCONJ
aiua-13277	7	15	they	they	PRON
aiua-13277	7	16	metabolize	metabolize	VERB
aiua-13277	7	17	theobromine	theobromine	NOUN
aiua-13277	7	18	very	very	ADV
aiua-13277	7	19	slowly	slowly	ADV
aiua-13277	7	20	.	.	PUNCT
aiua-13277	8	1	the	the	DET
aiua-13277	8	2	symptoms	symptom	NOUN
aiua-13277	8	3	of	of	ADP
aiua-13277	8	4	intoxication	intoxication	NOUN
aiua-13277	8	5	are	be	AUX
aiua-13277	8	6	excitation	excitation	NOUN
aiua-13277	8	7	,	,	PUNCT
aiua-13277	8	8	lowered	lower	VERB
aiua-13277	8	9	heart	heart	NOUN
aiua-13277	8	10	rate	rate	NOUN
aiua-13277	8	11	,	,	PUNCT
aiua-13277	8	12	convulsions	convulsion	NOUN
aiua-13277	8	13	and	and	CCONJ
aiua-13277	8	14	in	in	ADP
aiua-13277	8	15	the	the	DET
aiua-13277	8	16	most	most	ADV
aiua-13277	8	17	serious	serious	ADJ
aiua-13277	8	18	cases	case	NOUN
aiua-13277	8	19	death	death	NOUN
aiua-13277	8	20	(	(	PUNCT
aiua-13277	8	21	9	9	NUM
aiua-13277	8	22	)	)	PUNCT
aiua-13277	8	23	.	.	PUNCT
aiua-13277	9	1	theobromine	theobromine	NOUN
aiua-13277	9	2	has	have	VERB
aiua-13277	9	3	several	several	ADJ
aiua-13277	9	4	various	various	ADJ
aiua-13277	9	5	pharmacological	pharmacological	ADJ
aiua-13277	9	6	applications	application	NOUN
aiua-13277	9	7	including	include	VERB
aiua-13277	9	8	cough	cough	NOUN
aiua-13277	9	9	suppression	suppression	NOUN
aiua-13277	9	10	,	,	PUNCT
aiua-13277	9	11	increase	increase	NOUN
aiua-13277	9	12	of	of	ADP
aiua-13277	9	13	plasma	plasma	NOUN
aiua-13277	9	14	hdl	hdl	PROPN
aiua-13277	9	15	cholesterol	cholesterol	NOUN
aiua-13277	9	16	and	and	CCONJ
aiua-13277	9	17	decrease	decrease	NOUN
aiua-13277	9	18	of	of	ADP
aiua-13277	9	19	plasma	plasma	NOUN
aiua-13277	9	20	ldl	ldl	NOUN
aiua-13277	9	21	cholesterol	cholesterol	NOUN
aiua-13277	9	22	,	,	PUNCT
aiua-13277	9	23	protection	protection	NOUN
aiua-13277	9	24	of	of	ADP
aiua-13277	9	25	enamel	enamel	NOUN
aiua-13277	9	26	surface	surface	NOUN
aiua-13277	9	27	(	(	PUNCT
aiua-13277	9	28	10	10	NUM
aiua-13277	9	29	-	-	SYM
aiua-13277	9	30	13	13	NUM
aiua-13277	9	31	)	)	PUNCT
aiua-13277	9	32	.	.	PUNCT
aiua-13277	10	1	a	a	DET
aiua-13277	10	2	derivative	derivative	NOUN
aiua-13277	10	3	of	of	ADP
aiua-13277	10	4	theobromine	theobromine	NOUN
aiua-13277	10	5	,	,	PUNCT
aiua-13277	10	6	7	7	NUM
aiua-13277	10	7	-	-	PUNCT
aiua-13277	10	8	methylxanthine	methylxanthine	NOUN
aiua-13277	10	9	,	,	PUNCT
aiua-13277	10	10	has	have	AUX
aiua-13277	10	11	been	be	AUX
aiua-13277	10	12	used	use	VERB
aiua-13277	10	13	for	for	ADP
aiua-13277	10	14	the	the	DET
aiua-13277	10	15	treatment	treatment	NOUN
aiua-13277	10	16	of	of	ADP
aiua-13277	10	17	myopia	myopia	NOUN
aiua-13277	10	18	(	(	PUNCT
aiua-13277	10	19	14	14	NUM
aiua-13277	10	20	)	)	PUNCT
aiua-13277	10	21	.	.	PUNCT
aiua-13277	11	1	theobromine	theobromine	NOUN
aiua-13277	11	2	should	should	AUX
aiua-13277	11	3	be	be	AUX
aiua-13277	11	4	administered	administer	VERB
aiua-13277	11	5	as	as	ADP
aiua-13277	11	6	extract	extract	NOUN
aiua-13277	11	7	of	of	ADP
aiua-13277	11	8	cocoa	cocoa	NOUN
aiua-13277	11	9	beans	bean	NOUN
aiua-13277	11	10	rather	rather	ADV
aiua-13277	11	11	than	than	ADP
aiua-13277	11	12	chocolate	chocolate	NOUN
aiua-13277	11	13	that	that	PRON
aiua-13277	11	14	contains	contain	VERB
aiua-13277	11	15	large	large	ADJ
aiua-13277	11	16	amounts	amount	NOUN
aiua-13277	11	17	of	of	ADP
aiua-13277	11	18	sugar	sugar	NOUN
aiua-13277	11	19	and	and	CCONJ
aiua-13277	11	20	oxalate	oxalate	NOUN
aiua-13277	11	21	,	,	PUNCT
aiua-13277	11	22	that	that	PRON
aiua-13277	11	23	should	should	AUX
aiua-13277	11	24	be	be	AUX
aiua-13277	11	25	avoided	avoid	VERB
aiua-13277	11	26	in	in	ADP
aiua-13277	11	27	subjects	subject	NOUN
aiua-13277	11	28	with	with	ADP
aiua-13277	11	29	diabetes	diabetes	NOUN
aiua-13277	11	30	type	type	NOUN
aiua-13277	11	31	2	2	NUM
aiua-13277	11	32	or	or	CCONJ
aiua-13277	11	33	metabolic	metabolic	NOUN
aiua-13277	11	34	syndrome	syndrome	NOUN
aiua-13277	11	35	and	and	CCONJ
aiua-13277	11	36	calcium	calcium	NOUN
aiua-13277	11	37	oxalate	oxalate	NOUN
aiua-13277	11	38	renal	renal	ADJ
aiua-13277	11	39	stone	stone	NOUN
aiua-13277	11	40	formers	former	NOUN
aiua-13277	11	41	.	.	PUNCT
aiua-13277	12	1	treatment	treatment	NOUN
aiua-13277	12	2	and	and	CCONJ
aiua-13277	12	3	prevention	prevention	NOUN
aiua-13277	12	4	of	of	ADP
aiua-13277	12	5	uric	uric	ADJ
aiua-13277	12	6	acid	acid	NOUN
aiua-13277	12	7	stones	stone	NOUN
aiua-13277	12	8	uric	uric	ADJ
aiua-13277	12	9	acid	acid	ADJ
aiua-13277	12	10	urinary	urinary	ADJ
aiua-13277	12	11	stones	stone	NOUN
aiua-13277	12	12	account	account	VERB
aiua-13277	12	13	for	for	ADP
aiua-13277	12	14	about	about	ADV
aiua-13277	12	15	10	10	NUM
aiua-13277	12	16	%	%	NOUN
aiua-13277	12	17	of	of	ADP
aiua-13277	12	18	all	all	DET
aiua-13277	12	19	the	the	DET
aiua-13277	12	20	urinary	urinary	ADJ
aiua-13277	12	21	stones	stone	NOUN
aiua-13277	12	22	although	although	SCONJ
aiua-13277	12	23	it	it	PRON
aiua-13277	12	24	is	be	AUX
aiua-13277	12	25	predictable	predictable	ADJ
aiua-13277	12	26	an	an	DET
aiua-13277	12	27	increase	increase	NOUN
aiua-13277	12	28	of	of	ADP
aiua-13277	12	29	their	their	PRON
aiua-13277	12	30	prevalence	prevalence	NOUN
aiua-13277	12	31	because	because	SCONJ
aiua-13277	12	32	of	of	ADP
aiua-13277	12	33	demographic	demographic	ADJ
aiua-13277	12	34	and	and	CCONJ
aiua-13277	12	35	climate	climate	NOUN
aiua-13277	12	36	changes	change	NOUN
aiua-13277	12	37	(	(	PUNCT
aiua-13277	12	38	15	15	NUM
aiua-13277	12	39	,	,	PUNCT
aiua-13277	12	40	16	16	NUM
aiua-13277	12	41	)	)	PUNCT
aiua-13277	12	42	.	.	PUNCT
aiua-13277	13	1	uric	uric	ADJ
aiua-13277	13	2	acid	acid	NOUN
aiua-13277	13	3	stones	stone	NOUN
aiua-13277	13	4	form	form	NOUN
aiua-13277	13	5	by	by	ADP
aiua-13277	13	6	crystallization	crystallization	NOUN
aiua-13277	13	7	of	of	ADP
aiua-13277	13	8	urinary	urinary	ADJ
aiua-13277	13	9	uric	uric	ADJ
aiua-13277	13	10	acid	acid	NOUN
aiua-13277	13	11	when	when	SCONJ
aiua-13277	13	12	its	its	PRON
aiua-13277	13	13	concentration	concentration	NOUN
aiua-13277	13	14	is	be	AUX
aiua-13277	13	15	above	above	ADP
aiua-13277	13	16	the	the	DET
aiua-13277	13	17	threshold	threshold	NOUN
aiua-13277	13	18	of	of	ADP
aiua-13277	13	19	solubility	solubility	NOUN
aiua-13277	13	20	which	which	PRON
aiua-13277	13	21	depends	depend	VERB
aiua-13277	13	22	on	on	ADP
aiua-13277	13	23	ph	ph	PROPN
aiua-13277	13	24	.	.	PUNCT
aiua-13277	14	1	it	it	PRON
aiua-13277	14	2	ranges	range	VERB
aiua-13277	14	3	from	from	ADP
aiua-13277	14	4	110	110	NUM
aiua-13277	14	5	mg	mg	PROPN
aiua-13277	14	6	/	/	SYM
aiua-13277	14	7	l	l	NOUN
aiua-13277	14	8	for	for	ADP
aiua-13277	14	9	urinary	urinary	ADJ
aiua-13277	14	10	ph	ph	NOUN
aiua-13277	14	11	below	below	ADP
aiua-13277	14	12	5.0	5.0	NUM
aiua-13277	14	13	to	to	PART
aiua-13277	14	14	250	250	NUM
aiua-13277	14	15	mg	mg	NOUN
aiua-13277	14	16	/	/	SYM
aiua-13277	14	17	l	l	NOUN
aiua-13277	14	18	for	for	ADP
aiua-13277	14	19	ph	ph	ADJ
aiua-13277	14	20	5.5	5.5	NUM
aiua-13277	14	21	and	and	CCONJ
aiua-13277	14	22	up	up	ADP
aiua-13277	14	23	to	to	PART
aiua-13277	14	24	600	600	NUM
aiua-13277	14	25	mg	mg	NOUN
aiua-13277	14	26	for	for	ADP
aiua-13277	14	27	a	a	DET
aiua-13277	14	28	ph	ph	NOUN
aiua-13277	14	29	over	over	ADP
aiua-13277	14	30	6.0	6.0	NUM
aiua-13277	14	31	.	.	PUNCT
aiua-13277	15	1	urinary	urinary	ADJ
aiua-13277	15	2	saturation	saturation	NOUN
aiua-13277	15	3	for	for	ADP
aiua-13277	15	4	uric	uric	ADJ
aiua-13277	15	5	acid	acid	NOUN
aiua-13277	15	6	depends	depend	VERB
aiua-13277	15	7	on	on	ADP
aiua-13277	15	8	urinary	urinary	ADJ
aiua-13277	15	9	ph	ph	ADJ
aiua-13277	15	10	and	and	CCONJ
aiua-13277	15	11	urinary	urinary	ADJ
aiua-13277	15	12	uric	uric	ADJ
aiua-13277	15	13	acid	acid	NOUN
aiua-13277	15	14	concentration	concentration	NOUN
aiua-13277	15	15	(	(	PUNCT
aiua-13277	15	16	17	17	NUM
aiua-13277	15	17	-	-	SYM
aiua-13277	15	18	19	19	NUM
aiua-13277	15	19	)	)	PUNCT
aiua-13277	15	20	.	.	PUNCT
aiua-13277	16	1	when	when	SCONJ
aiua-13277	16	2	urine	urine	NOUN
aiua-13277	16	3	is	be	AUX
aiua-13277	16	4	supersaturated	supersaturate	VERB
aiua-13277	16	5	with	with	ADP
aiua-13277	16	6	respect	respect	NOUN
aiua-13277	16	7	to	to	ADP
aiua-13277	16	8	uric	uric	ADJ
aiua-13277	16	9	acid	acid	NOUN
aiua-13277	16	10	,	,	PUNCT
aiua-13277	16	11	crystal	crystal	NOUN
aiua-13277	16	12	formation	formation	NOUN
aiua-13277	16	13	is	be	AUX
aiua-13277	16	14	possible	possible	ADJ
aiua-13277	16	15	,	,	PUNCT
aiua-13277	16	16	although	although	SCONJ
aiua-13277	16	17	above	above	ADP
aiua-13277	16	18	this	this	DET
aiua-13277	16	19	threshold	threshold	NOUN
aiua-13277	16	20	there	there	PRON
aiua-13277	16	21	is	be	VERB
aiua-13277	16	22	an	an	DET
aiua-13277	16	23	interval	interval	NOUN
aiua-13277	16	24	of	of	ADP
aiua-13277	16	25	saturation	saturation	NOUN
aiua-13277	16	26	values	value	NOUN
aiua-13277	16	27	at	at	ADP
aiua-13277	16	28	which	which	PRON
aiua-13277	16	29	the	the	DET
aiua-13277	16	30	solution	solution	NOUN
aiua-13277	16	31	is	be	AUX
aiua-13277	16	32	theobromine	theobromine	ADJ
aiua-13277	16	33	(	(	PUNCT
aiua-13277	16	34	or	or	CCONJ
aiua-13277	16	35	3,7	3,7	NUM
aiua-13277	16	36	-	-	PUNCT
aiua-13277	16	37	dimethylxanthine	dimethylxanthine	NOUN
aiua-13277	16	38	)	)	PUNCT
aiua-13277	16	39	is	be	AUX
aiua-13277	16	40	a	a	DET
aiua-13277	16	41	natural	natural	ADJ
aiua-13277	16	42	alkaloid	alkaloid	NOUN
aiua-13277	16	43	present	present	NOUN
aiua-13277	16	44	in	in	ADP
aiua-13277	16	45	cocoa	cocoa	NOUN
aiua-13277	16	46	plant	plant	NOUN
aiua-13277	16	47	and	and	CCONJ
aiua-13277	16	48	its	its	PRON
aiua-13277	16	49	derivatives	derivative	NOUN
aiua-13277	16	50	,	,	PUNCT
aiua-13277	16	51	such	such	ADJ
aiua-13277	16	52	as	as	ADP
aiua-13277	16	53	chocolate	chocolate	NOUN
aiua-13277	16	54	.	.	PUNCT
aiua-13277	17	1	about	about	ADV
aiua-13277	17	2	20	20	NUM
aiua-13277	17	3	%	%	NOUN
aiua-13277	17	4	of	of	ADP
aiua-13277	17	5	ingested	ingest	VERB
aiua-13277	17	6	theobromine	theobromine	NOUN
aiua-13277	17	7	is	be	AUX
aiua-13277	17	8	excreted	excrete	VERB
aiua-13277	17	9	unchanged	unchanged	ADJ
aiua-13277	17	10	in	in	ADP
aiua-13277	17	11	the	the	DET
aiua-13277	17	12	urine	urine	NOUN
aiua-13277	17	13	.	.	PUNCT
aiua-13277	18	1	theobromine	theobromine	NOUN
aiua-13277	18	2	also	also	ADV
aiua-13277	18	3	derived	derive	VERB
aiua-13277	18	4	from	from	ADP
aiua-13277	18	5	caffeine	caffeine	NOUN
aiua-13277	18	6	that	that	PRON
aiua-13277	18	7	is	be	AUX
aiua-13277	18	8	metabolized	metabolize	VERB
aiua-13277	18	9	into	into	ADP
aiua-13277	18	10	theobromine	theobromine	NOUN
aiua-13277	18	11	by	by	ADP
aiua-13277	18	12	12	12	NUM
aiua-13277	18	13	%	%	NOUN
aiua-13277	18	14	.	.	PUNCT
aiua-13277	19	1	the	the	DET
aiua-13277	19	2	primary	primary	ADJ
aiua-13277	19	3	metabolites	metabolite	NOUN
aiua-13277	19	4	of	of	ADP
aiua-13277	19	5	theobromine	theobromine	NOUN
aiua-13277	19	6	are	be	AUX
aiua-13277	19	7	3	3	NUM
aiua-13277	19	8	-	-	PUNCT
aiua-13277	19	9	methylxantine	methylxantine	NOUN
aiua-13277	19	10	,	,	PUNCT
aiua-13277	19	11	7	7	NUM
aiua-13277	19	12	-	-	PUNCT
aiua-13277	19	13	methylxantine	methylxantine	NOUN
aiua-13277	19	14	,	,	PUNCT
aiua-13277	19	15	7	7	NUM
aiua-13277	19	16	-	-	PUNCT
aiua-13277	19	17	methyluric	methyluric	ADJ
aiua-13277	19	18	acid	acid	NOUN
aiua-13277	19	19	and	and	CCONJ
aiua-13277	19	20	3,7	3,7	NUM
aiua-13277	19	21	-	-	PUNCT
aiua-13277	19	22	dimethyluric	dimethyluric	ADJ
aiua-13277	19	23	acid	acid	NOUN
aiua-13277	19	24	.	.	PUNCT
aiua-13277	20	1	theobromine	theobromine	NOUN
aiua-13277	20	2	has	have	VERB
aiua-13277	20	3	an	an	DET
aiua-13277	20	4	inhibitory	inhibitory	ADJ
aiua-13277	20	5	activity	activity	NOUN
aiua-13277	20	6	of	of	ADP
aiua-13277	20	7	uric	uric	ADJ
aiua-13277	20	8	acid	acid	NOUN
aiua-13277	20	9	crystallization	crystallization	NOUN
aiua-13277	20	10	,	,	PUNCT
aiua-13277	20	11	because	because	SCONJ
aiua-13277	20	12	it	it	PRON
aiua-13277	20	13	has	have	VERB
aiua-13277	20	14	a	a	DET
aiua-13277	20	15	structural	structural	ADJ
aiua-13277	20	16	pattern	pattern	NOUN
aiua-13277	20	17	very	very	ADV
aiua-13277	20	18	similar	similar	ADJ
aiua-13277	20	19	to	to	ADP
aiua-13277	20	20	uric	uric	ADJ
aiua-13277	20	21	acid	acid	NOUN
aiua-13277	20	22	and	and	CCONJ
aiua-13277	20	23	can	can	AUX
aiua-13277	20	24	substitute	substitute	VERB
aiua-13277	20	25	uric	uric	ADJ
aiua-13277	20	26	acid	acid	NOUN
aiua-13277	20	27	molecules	molecule	NOUN
aiua-13277	20	28	in	in	ADP
aiua-13277	20	29	the	the	DET
aiua-13277	20	30	corresponding	corresponding	ADJ
aiua-13277	20	31	uric	uric	ADJ
aiua-13277	20	32	acid	acid	NOUN
aiua-13277	20	33	crystals	crystal	NOUN
aiua-13277	20	34	,	,	PUNCT
aiua-13277	20	35	making	make	VERB
aiua-13277	20	36	them	they	PRON
aiua-13277	20	37	longer	long	ADJ
aiua-13277	20	38	and	and	CCONJ
aiua-13277	20	39	thinner	thin	ADJ
aiua-13277	20	40	and	and	CCONJ
aiua-13277	20	41	decreasing	decrease	VERB
aiua-13277	20	42	their	their	PRON
aiua-13277	20	43	growth	growth	NOUN
aiua-13277	20	44	rate	rate	NOUN
aiua-13277	20	45	.	.	PUNCT
aiua-13277	21	1	theobromine	theobromine	NOUN
aiua-13277	21	2	also	also	ADV
aiua-13277	21	3	favors	favor	VERB
aiua-13277	21	4	the	the	DET
aiua-13277	21	5	dissolution	dissolution	NOUN
aiua-13277	21	6	of	of	ADP
aiua-13277	21	7	crystals	crystal	NOUN
aiua-13277	21	8	by	by	ADP
aiua-13277	21	9	decreasing	decrease	VERB
aiua-13277	21	10	supersaturation	supersaturation	NOUN
aiua-13277	21	11	of	of	ADP
aiua-13277	21	12	uric	uric	ADJ
aiua-13277	21	13	acid	acid	NOUN
aiua-13277	21	14	by	by	ADP
aiua-13277	21	15	forming	form	VERB
aiua-13277	21	16	aggregates	aggregate	NOUN
aiua-13277	21	17	with	with	ADP
aiua-13277	21	18	uric	uric	ADJ
aiua-13277	21	19	acid	acid	NOUN
aiua-13277	21	20	through	through	ADP
aiua-13277	21	21	hydrogen	hydrogen	NOUN
aiua-13277	21	22	bonds	bond	NOUN
aiua-13277	21	23	and	and	CCONJ
aiua-13277	21	24	aromatic	aromatic	ADJ
aiua-13277	21	25	stacking	stacking	NOUN
aiua-13277	21	26	interactions	interaction	NOUN
aiua-13277	21	27	(	(	PUNCT
aiua-13277	21	28	-stacking	-stacking	ADJ
aiua-13277	21	29	bonds	bond	NOUN
aiua-13277	21	30	)	)	PUNCT
aiua-13277	21	31	increasing	increase	VERB
aiua-13277	21	32	urinary	urinary	ADJ
aiua-13277	21	33	solubility	solubility	NOUN
aiua-13277	21	34	of	of	ADP
aiua-13277	21	35	uric	uric	ADJ
aiua-13277	21	36	acid	acid	NOUN
aiua-13277	21	37	.	.	PUNCT
aiua-13277	22	1	theobromine	theobromine	NOUN
aiua-13277	22	2	can	can	AUX
aiua-13277	22	3	be	be	AUX
aiua-13277	22	4	used	use	VERB
aiua-13277	22	5	for	for	ADP
aiua-13277	22	6	uric	uric	ADJ
aiua-13277	22	7	acid	acid	NOUN
aiua-13277	22	8	stone	stone	NOUN
aiua-13277	22	9	dissolution	dissolution	NOUN
aiua-13277	22	10	in	in	ADP
aiua-13277	22	11	combination	combination	NOUN
aiua-13277	22	12	with	with	ADP
aiua-13277	22	13	alkalinization	alkalinization	NOUN
aiua-13277	22	14	to	to	PART
aiua-13277	22	15	reduce	reduce	VERB
aiua-13277	22	16	the	the	DET
aiua-13277	22	17	dose	dose	NOUN
aiua-13277	22	18	of	of	ADP
aiua-13277	22	19	citrate	citrate	NOUN
aiua-13277	22	20	,	,	PUNCT
aiua-13277	22	21	thus	thus	ADV
aiua-13277	22	22	preventing	prevent	VERB
aiua-13277	22	23	excessive	excessive	ADJ
aiua-13277	22	24	alkalinization	alkalinization	NOUN
aiua-13277	22	25	and	and	CCONJ
aiua-13277	22	26	the	the	DET
aiua-13277	22	27	risk	risk	NOUN
aiua-13277	22	28	of	of	ADP
aiua-13277	22	29	formation	formation	NOUN
aiua-13277	22	30	of	of	ADP
aiua-13277	22	31	sodium	sodium	NOUN
aiua-13277	22	32	urate	urate	NOUN
aiua-13277	22	33	crystals	crystal	NOUN
aiua-13277	22	34	.	.	PUNCT
aiua-13277	23	1	theobromine	theobromine	NOUN
aiua-13277	23	2	could	could	AUX
aiua-13277	23	3	also	also	ADV
aiua-13277	23	4	be	be	AUX
aiua-13277	23	5	used	use	VERB
aiua-13277	23	6	to	to	PART
aiua-13277	23	7	treat	treat	VERB
aiua-13277	23	8	patient	patient	ADJ
aiua-13277	23	9	with	with	ADP
aiua-13277	23	10	xanthine	xanthine	NOUN
aiua-13277	23	11	stones	stone	NOUN
aiua-13277	23	12	that	that	PRON
aiua-13277	23	13	can	can	AUX
aiua-13277	23	14	not	not	PART
aiua-13277	23	15	be	be	AUX
aiua-13277	23	16	dissolved	dissolve	VERB
aiua-13277	23	17	by	by	ADP
aiua-13277	23	18	alkalinization	alkalinization	NOUN
aiua-13277	23	19	because	because	SCONJ
aiua-13277	23	20	the	the	DET
aiua-13277	23	21	solubility	solubility	NOUN
aiua-13277	23	22	of	of	ADP
aiua-13277	23	23	xanthine	xanthine	NOUN
aiua-13277	23	24	is	be	AUX
aiua-13277	23	25	relatively	relatively	ADV
aiua-13277	23	26	independent	independent	ADJ
aiua-13277	23	27	of	of	ADP
aiua-13277	23	28	urinary	urinary	ADJ
aiua-13277	23	29	ph	ph	PROPN
aiua-13277	23	30	.	.	PUNCT
aiua-13277	24	1	a	a	DET
aiua-13277	24	2	metabolite	metabolite	NOUN
aiua-13277	24	3	of	of	ADP
aiua-13277	24	4	theobromine	theobromine	NOUN
aiua-13277	24	5	,	,	PUNCT
aiua-13277	24	6	7	7	NUM
aiua-13277	24	7	-	-	PUNCT
aiua-13277	24	8	methylxanthine	methylxanthine	NOUN
aiua-13277	24	9	,	,	PUNCT
aiua-13277	24	10	has	have	VERB
aiua-13277	24	11	the	the	DET
aiua-13277	24	12	potential	potential	NOUN
aiua-13277	24	13	to	to	PART
aiua-13277	24	14	be	be	AUX
aiua-13277	24	15	used	use	VERB
aiua-13277	24	16	for	for	ADP
aiua-13277	24	17	the	the	DET
aiua-13277	24	18	prevention	prevention	NOUN
aiua-13277	24	19	of	of	ADP
aiua-13277	24	20	the	the	DET
aiua-13277	24	21	formation	formation	NOUN
aiua-13277	24	22	of	of	ADP
aiua-13277	24	23	sodium	sodium	NOUN
aiua-13277	24	24	urate	urate	NOUN
aiua-13277	24	25	crystals	crystal	NOUN
aiua-13277	24	26	in	in	ADP
aiua-13277	24	27	the	the	DET
aiua-13277	24	28	synovial	synovial	ADJ
aiua-13277	24	29	fluid	fluid	NOUN
aiua-13277	24	30	of	of	ADP
aiua-13277	24	31	gouty	gouty	ADJ
aiua-13277	24	32	patients	patient	NOUN
aiua-13277	24	33	.	.	PUNCT
aiua-13277	25	1	key	key	ADJ
aiua-13277	25	2	words	word	NOUN
aiua-13277	25	3	:	:	PUNCT
aiua-13277	25	4	theobromine	theobromine	NOUN
aiua-13277	25	5	;	;	PUNCT
aiua-13277	25	6	uric	uric	ADJ
aiua-13277	25	7	acid	acid	NOUN
aiua-13277	25	8	;	;	PUNCT
aiua-13277	25	9	urinary	urinary	ADJ
aiua-13277	25	10	calculi	calculi	PROPN
aiua-13277	25	11	;	;	PUNCT
aiua-13277	25	12	xanthine	xanthine	NOUN
aiua-13277	25	13	;	;	PUNCT
aiua-13277	25	14	gout	gout	NOUN
aiua-13277	25	15	.	.	PUNCT
aiua-13277	25	16	submitted	submit	VERB
aiua-13277	25	17	21	21	NUM
aiua-13277	25	18	october	october	PROPN
aiua-13277	25	19	2024	2024	NUM
aiua-13277	25	20	;	;	PUNCT
aiua-13277	25	21	accepted	accept	VERB
aiua-13277	25	22	24	24	NUM
aiua-13277	25	23	october	october	PROPN
aiua-13277	25	24	2024	2024	NUM
aiua-13277	25	25	introduction	introduction	NOUN
aiua-13277	25	26	theobromine	theobromine	NOUN
aiua-13277	25	27	(	(	PUNCT
aiua-13277	25	28	or	or	CCONJ
aiua-13277	25	29	3,7	3,7	NUM
aiua-13277	25	30	-	-	PUNCT
aiua-13277	25	31	dimethylxanthine	dimethylxanthine	NOUN
aiua-13277	25	32	)	)	PUNCT
aiua-13277	25	33	is	be	AUX
aiua-13277	25	34	a	a	DET
aiua-13277	25	35	natural	natural	ADJ
aiua-13277	25	36	alkaloid	alkaloid	NOUN
aiua-13277	25	37	present	present	NOUN
aiua-13277	25	38	in	in	ADP
aiua-13277	25	39	theobroma	theobroma	NOUN
aiua-13277	25	40	cacao	cacao	NOUN
aiua-13277	25	41	(	(	PUNCT
aiua-13277	25	42	cocoa	cocoa	NOUN
aiua-13277	25	43	plant	plant	NOUN
aiua-13277	25	44	)	)	PUNCT
aiua-13277	25	45	and	and	CCONJ
aiua-13277	25	46	its	its	PRON
aiua-13277	25	47	derivatives	derivative	NOUN
aiua-13277	25	48	.	.	PUNCT
aiua-13277	26	1	it	it	PRON
aiua-13277	26	2	is	be	AUX
aiua-13277	26	3	found	find	VERB
aiua-13277	26	4	in	in	ADP
aiua-13277	26	5	chocolate	chocolate	NOUN
aiua-13277	26	6	,	,	PUNCT
aiua-13277	26	7	and	and	CCONJ
aiua-13277	26	8	it	it	PRON
aiua-13277	26	9	is	be	AUX
aiua-13277	26	10	also	also	ADV
aiua-13277	26	11	present	present	ADJ
aiua-13277	26	12	in	in	ADP
aiua-13277	26	13	small	small	ADJ
aiua-13277	26	14	quantities	quantity	NOUN
aiua-13277	26	15	in	in	ADP
aiua-13277	26	16	tea	tea	NOUN
aiua-13277	26	17	leaves	leave	NOUN
aiua-13277	26	18	(	(	PUNCT
aiua-13277	26	19	1	1	NUM
aiua-13277	26	20	,	,	PUNCT
aiua-13277	26	21	2	2	NUM
aiua-13277	26	22	)	)	PUNCT
aiua-13277	26	23	.	.	PUNCT
aiua-13277	27	1	chemically	chemically	ADV
aiua-13277	27	2	it	it	PRON
aiua-13277	27	3	is	be	AUX
aiua-13277	27	4	a	a	DET
aiua-13277	27	5	xanthine	xanthine	NOUN
aiua-13277	27	6	,	,	PUNCT
aiua-13277	27	7	a	a	DET
aiua-13277	27	8	derivative	derivative	NOUN
aiua-13277	27	9	of	of	ADP
aiua-13277	27	10	purine	purine	NOUN
aiua-13277	27	11	,	,	PUNCT
aiua-13277	27	12	whose	whose	DET
aiua-13277	27	13	related	related	ADJ
aiua-13277	27	14	compounds	compound	NOUN
aiua-13277	27	15	include	include	VERB
aiua-13277	27	16	theophylline	theophylline	NOUN
aiua-13277	27	17	,	,	PUNCT
aiua-13277	27	18	caffeine	caffeine	NOUN
aiua-13277	27	19	,	,	PUNCT
aiua-13277	27	20	paraxanthine	paraxanthine	NOUN
aiua-13277	27	21	,	,	PUNCT
aiua-13277	27	22	and	and	CCONJ
aiua-13277	27	23	7	7	NUM
aiua-13277	27	24	-	-	PUNCT
aiua-13277	27	25	methylxanthine	methylxanthine	NOUN
aiua-13277	27	26	,	,	PUNCT
aiua-13277	27	27	each	each	PRON
aiua-13277	27	28	of	of	ADP
aiua-13277	27	29	which	which	PRON
aiua-13277	27	30	differ	differ	VERB
aiua-13277	27	31	in	in	ADP
aiua-13277	27	32	the	the	DET
aiua-13277	27	33	number	number	NOUN
aiua-13277	27	34	or	or	CCONJ
aiua-13277	27	35	placement	placement	NOUN
aiua-13277	27	36	of	of	ADP
aiua-13277	27	37	the	the	DET
aiua-13277	27	38	methyl	methyl	NOUN
aiua-13277	27	39	groups	group	NOUN
aiua-13277	27	40	.	.	PUNCT
aiua-13277	28	1	theobromine	theobromine	NOUN
aiua-13277	28	2	is	be	AUX
aiua-13277	28	3	derived	derive	VERB
aiua-13277	28	4	from	from	ADP
aiua-13277	28	5	the	the	DET
aiua-13277	28	6	nucleoside	nucleoside	NOUN
aiua-13277	28	7	xanthosine	xanthosine	NOUN
aiua-13277	28	8	by	by	ADP
aiua-13277	28	9	cleavage	cleavage	NOUN
aiua-13277	28	10	of	of	ADP
aiua-13277	28	11	the	the	DET
aiua-13277	28	12	ribose	ribose	NOUN
aiua-13277	28	13	and	and	CCONJ
aiua-13277	28	14	n	n	CCONJ
aiua-13277	28	15	-	-	PUNCT
aiua-13277	28	16	methylation	methylation	NOUN
aiua-13277	28	17	to	to	ADP
aiua-13277	28	18	7	7	NUM
aiua-13277	28	19	-	-	PUNCT
aiua-13277	28	20	methylxanthosine	methylxanthosine	NOUN
aiua-13277	28	21	.	.	PUNCT
aiua-13277	29	1	theobromine	theobromine	NOUN
aiua-13277	29	2	is	be	AUX
aiua-13277	29	3	slightly	slightly	ADV
aiua-13277	29	4	water	water	NOUN
aiua-13277	29	5	-	-	PUNCT
aiua-13277	29	6	soluble	soluble	ADJ
aiua-13277	29	7	but	but	CCONJ
aiua-13277	29	8	more	more	ADV
aiua-13277	29	9	fat	fat	ADJ
aiua-13277	29	10	-	-	PUNCT
aiua-13277	29	11	soluble	soluble	ADJ
aiua-13277	29	12	,	,	PUNCT
aiua-13277	29	13	therefore	therefore	ADV
aiua-13277	29	14	requires	require	VERB
aiua-13277	29	15	2	2	NUM
aiua-13277	29	16	-	-	SYM
aiua-13277	29	17	3	3	NUM
aiua-13277	29	18	hours	hour	NOUN
aiua-13277	29	19	to	to	PART
aiua-13277	29	20	peak	peak	VERB
aiua-13277	29	21	,	,	PUNCT
aiua-13277	29	22	while	while	SCONJ
aiua-13277	29	23	caffein	caffein	NOUN
aiua-13277	29	24	is	be	AUX
aiua-13277	29	25	highly	highly	ADV
aiua-13277	29	26	water	water	NOUN
aiua-13277	29	27	-	-	PUNCT
aiua-13277	29	28	soluble	soluble	ADJ
aiua-13277	29	29	and	and	CCONJ
aiua-13277	29	30	peaks	peak	NOUN
aiua-13277	29	31	after	after	ADP
aiua-13277	29	32	only	only	ADV
aiua-13277	29	33	30	30	NUM
aiua-13277	29	34	minutes	minute	NOUN
aiua-13277	29	35	.	.	PUNCT
aiua-13277	30	1	in	in	ADP
aiua-13277	30	2	the	the	DET
aiua-13277	30	3	liver	liver	NOUN
aiua-13277	30	4	,	,	PUNCT
aiua-13277	30	5	it	it	PRON
aiua-13277	30	6	is	be	AUX
aiua-13277	30	7	metabolized	metabolize	VERB
aiua-13277	30	8	into	into	ADP
aiua-13277	30	9	xanthine	xanthine	NOUN
aiua-13277	30	10	and	and	CCONJ
aiua-13277	30	11	subsequently	subsequently	ADV
aiua-13277	30	12	into	into	ADP
aiua-13277	30	13	methyluric	methyluric	ADJ
aiua-13277	30	14	acid	acid	NOUN
aiua-13277	30	15	.	.	PUNCT
aiua-13277	31	1	theobromine	theobromine	NOUN
aiua-13277	31	2	for	for	ADP
aiua-13277	31	3	treatment	treatment	NOUN
aiua-13277	31	4	of	of	ADP
aiua-13277	31	5	uric	uric	ADJ
aiua-13277	31	6	acid	acid	NOUN
aiua-13277	31	7	stones	stone	NOUN
aiua-13277	31	8	and	and	CCONJ
aiua-13277	31	9	other	other	ADJ
aiua-13277	31	10	diseases	disease	NOUN
aiua-13277	31	11	alberto	alberto	PROPN
aiua-13277	31	12	trinchieri	trinchieri	PROPN
aiua-13277	31	13	c.d.c	c.d.c	PROPN
aiua-13277	31	14	.	.	PUNCT
aiua-13277	32	1	ambrosiana	ambrosiana	PROPN
aiua-13277	32	2	,	,	PUNCT
aiua-13277	32	3	cesano	cesano	PROPN
aiua-13277	32	4	boscone	boscone	PROPN
aiua-13277	32	5	,	,	PUNCT
aiua-13277	32	6	milan	milan	PROPN
aiua-13277	32	7	,	,	PUNCT
aiua-13277	32	8	italy	italy	PROPN
aiua-13277	32	9	.	.	PUNCT
aiua-13277	33	1	doi	doi	PROPN
aiua-13277	33	2	:	:	PUNCT
aiua-13277	33	3	10.4081	10.4081	NUM
aiua-13277	33	4	/	/	SYM
aiua-13277	33	5	aiua.2024.13277	aiua.2024.13277	PROPN
aiua-13277	33	6	summary	summary	NOUN
aiua-13277	33	7	archivio	archivio	NOUN
aiua-13277	33	8	italiano	italiano	X
aiua-13277	33	9	di	di	X
aiua-13277	33	10	urologia	urologia	PROPN
aiua-13277	33	11	e	e	PROPN
aiua-13277	33	12	andrologia	andrologia	NOUN
aiua-13277	33	13	2024	2024	NUM
aiua-13277	33	14	;	;	PUNCT
aiua-13277	33	15	96(4):13277	96(4):13277	NUM
aiua-13277	33	16	a.	a.	NOUN
aiua-13277	33	17	trinchieri	trinchieri	PROPN
aiua-13277	33	18	2	2	NUM
aiua-13277	33	19	metastable	metastable	ADJ
aiua-13277	33	20	that	that	PRON
aiua-13277	33	21	means	mean	VERB
aiua-13277	33	22	that	that	SCONJ
aiua-13277	33	23	preformed	preformed	ADJ
aiua-13277	33	24	crystals	crystal	NOUN
aiua-13277	33	25	can	can	AUX
aiua-13277	33	26	grow	grow	VERB
aiua-13277	33	27	but	but	CCONJ
aiua-13277	33	28	there	there	PRON
aiua-13277	33	29	is	be	VERB
aiua-13277	33	30	no	no	DET
aiua-13277	33	31	formation	formation	NOUN
aiua-13277	33	32	of	of	ADP
aiua-13277	33	33	new	new	ADJ
aiua-13277	33	34	crystals	crystal	NOUN
aiua-13277	33	35	.	.	PUNCT
aiua-13277	34	1	above	above	ADP
aiua-13277	34	2	the	the	DET
aiua-13277	34	3	upper	upper	ADJ
aiua-13277	34	4	limit	limit	NOUN
aiua-13277	34	5	of	of	ADP
aiua-13277	34	6	the	the	DET
aiua-13277	34	7	metastable	metastable	ADJ
aiua-13277	34	8	zone	zone	NOUN
aiua-13277	34	9	of	of	ADP
aiua-13277	34	10	saturation	saturation	NOUN
aiua-13277	34	11	crystals	crystal	NOUN
aiua-13277	34	12	form	form	VERB
aiua-13277	34	13	spontaneously	spontaneously	ADV
aiua-13277	34	14	.	.	PUNCT
aiua-13277	35	1	other	other	ADJ
aiua-13277	35	2	factors	factor	NOUN
aiua-13277	35	3	can	can	AUX
aiua-13277	35	4	interfere	interfere	VERB
aiua-13277	35	5	with	with	ADP
aiua-13277	35	6	uric	uric	ADJ
aiua-13277	35	7	acid	acid	NOUN
aiua-13277	35	8	crystallization	crystallization	NOUN
aiua-13277	35	9	in	in	ADP
aiua-13277	35	10	the	the	DET
aiua-13277	35	11	urine	urine	NOUN
aiua-13277	35	12	as	as	ADP
aiua-13277	35	13	the	the	DET
aiua-13277	35	14	presence	presence	NOUN
aiua-13277	35	15	of	of	ADP
aiua-13277	35	16	heterogeneous	heterogeneous	ADJ
aiua-13277	35	17	nuclei	nucleus	NOUN
aiua-13277	35	18	that	that	PRON
aiua-13277	35	19	can	can	AUX
aiua-13277	35	20	facilitate	facilitate	VERB
aiua-13277	35	21	crystal	crystal	NOUN
aiua-13277	35	22	formation	formation	NOUN
aiua-13277	35	23	or	or	CCONJ
aiua-13277	35	24	inhibitors	inhibitor	NOUN
aiua-13277	35	25	of	of	ADP
aiua-13277	35	26	crystallization	crystallization	NOUN
aiua-13277	35	27	.	.	PUNCT
aiua-13277	36	1	uric	uric	ADJ
aiua-13277	36	2	acid	acid	NOUN
aiua-13277	36	3	stones	stone	NOUN
aiua-13277	36	4	can	can	AUX
aiua-13277	36	5	be	be	AUX
aiua-13277	36	6	dissolved	dissolve	VERB
aiua-13277	36	7	when	when	SCONJ
aiua-13277	36	8	urinary	urinary	ADJ
aiua-13277	36	9	saturation	saturation	NOUN
aiua-13277	36	10	is	be	AUX
aiua-13277	36	11	under	under	ADP
aiua-13277	36	12	the	the	DET
aiua-13277	36	13	threshold	threshold	NOUN
aiua-13277	36	14	of	of	ADP
aiua-13277	36	15	supersaturation	supersaturation	NOUN
aiua-13277	36	16	.	.	PUNCT
aiua-13277	37	1	alkalinization	alkalinization	NOUN
aiua-13277	37	2	alkalinization	alkalinization	NOUN
aiua-13277	37	3	by	by	ADP
aiua-13277	37	4	high	high	ADJ
aiua-13277	37	5	doses	dose	NOUN
aiua-13277	37	6	of	of	ADP
aiua-13277	37	7	citrate	citrate	NOUN
aiua-13277	37	8	and	and	CCONJ
aiua-13277	37	9	bicarbonate	bicarbonate	NOUN
aiua-13277	37	10	is	be	AUX
aiua-13277	37	11	commonly	commonly	ADV
aiua-13277	37	12	used	use	VERB
aiua-13277	37	13	for	for	ADP
aiua-13277	37	14	uric	uric	ADJ
aiua-13277	37	15	acid	acid	NOUN
aiua-13277	37	16	dissolution	dissolution	NOUN
aiua-13277	37	17	(	(	PUNCT
aiua-13277	37	18	20	20	NUM
aiua-13277	37	19	)	)	PUNCT
aiua-13277	37	20	.	.	PUNCT
aiua-13277	38	1	urinary	urinary	ADJ
aiua-13277	38	2	ph	ph	PROPN
aiua-13277	38	3	should	should	AUX
aiua-13277	38	4	be	be	AUX
aiua-13277	38	5	raised	raise	VERB
aiua-13277	38	6	over	over	ADP
aiua-13277	38	7	6	6	NUM
aiua-13277	38	8	,	,	PUNCT
aiua-13277	38	9	although	although	SCONJ
aiua-13277	38	10	higher	high	ADJ
aiua-13277	38	11	values	value	NOUN
aiua-13277	38	12	are	be	AUX
aiua-13277	38	13	not	not	PART
aiua-13277	38	14	recommended	recommend	VERB
aiua-13277	38	15	because	because	SCONJ
aiua-13277	38	16	a	a	DET
aiua-13277	38	17	urinary	urinary	ADJ
aiua-13277	38	18	ph	ph	NOUN
aiua-13277	38	19	above	above	ADP
aiua-13277	38	20	6.2	6.2	NUM
aiua-13277	38	21	can	can	AUX
aiua-13277	38	22	cause	cause	VERB
aiua-13277	38	23	the	the	DET
aiua-13277	38	24	formation	formation	NOUN
aiua-13277	38	25	of	of	ADP
aiua-13277	38	26	an	an	DET
aiua-13277	38	27	outer	outer	ADJ
aiua-13277	38	28	shell	shell	NOUN
aiua-13277	38	29	of	of	ADP
aiua-13277	38	30	insoluble	insoluble	ADJ
aiua-13277	38	31	calcium	calcium	NOUN
aiua-13277	38	32	phosphate	phosphate	NOUN
aiua-13277	38	33	salts	salt	NOUN
aiua-13277	38	34	that	that	PRON
aiua-13277	38	35	are	be	AUX
aiua-13277	38	36	less	less	ADV
aiua-13277	38	37	soluble	soluble	ADJ
aiua-13277	38	38	for	for	ADP
aiua-13277	38	39	higher	high	ADJ
aiua-13277	38	40	ph	ph	ADJ
aiua-13277	38	41	values	value	NOUN
aiua-13277	38	42	.	.	PUNCT
aiua-13277	39	1	furthermore	furthermore	ADV
aiua-13277	39	2	,	,	PUNCT
aiua-13277	39	3	in	in	ADP
aiua-13277	39	4	the	the	DET
aiua-13277	39	5	presence	presence	NOUN
aiua-13277	39	6	of	of	ADP
aiua-13277	39	7	hyperuricosuria	hyperuricosuria	NOUN
aiua-13277	39	8	,	,	PUNCT
aiua-13277	39	9	deposits	deposit	NOUN
aiua-13277	39	10	of	of	ADP
aiua-13277	39	11	sodium	sodium	NOUN
aiua-13277	39	12	and/or	and/or	CCONJ
aiua-13277	39	13	potassium	potassium	NOUN
aiua-13277	39	14	urate	urate	NOUN
aiua-13277	39	15	can	can	AUX
aiua-13277	39	16	form	form	VERB
aiua-13277	39	17	,	,	PUNCT
aiua-13277	39	18	because	because	SCONJ
aiua-13277	39	19	of	of	ADP
aiua-13277	39	20	reduced	reduce	VERB
aiua-13277	39	21	solubility	solubility	NOUN
aiua-13277	39	22	of	of	ADP
aiua-13277	39	23	such	such	ADJ
aiua-13277	39	24	urate	urate	ADJ
aiua-13277	39	25	salts	salt	NOUN
aiua-13277	39	26	at	at	ADP
aiua-13277	39	27	higher	high	ADJ
aiua-13277	39	28	ph	ph	ADJ
aiua-13277	39	29	values	value	NOUN
aiua-13277	39	30	(	(	PUNCT
aiua-13277	39	31	contrary	contrary	ADJ
aiua-13277	39	32	to	to	ADP
aiua-13277	39	33	what	what	PRON
aiua-13277	39	34	happens	happen	VERB
aiua-13277	39	35	for	for	ADP
aiua-13277	39	36	uric	uric	ADJ
aiua-13277	39	37	acid	acid	NOUN
aiua-13277	39	38	)	)	PUNCT
aiua-13277	39	39	.	.	PUNCT
aiua-13277	40	1	finally	finally	ADV
aiua-13277	40	2	,	,	PUNCT
aiua-13277	40	3	long	long	ADJ
aiua-13277	40	4	-	-	PUNCT
aiua-13277	40	5	term	term	NOUN
aiua-13277	40	6	treatment	treatment	NOUN
aiua-13277	40	7	with	with	ADP
aiua-13277	40	8	citrate	citrate	NOUN
aiua-13277	40	9	can	can	AUX
aiua-13277	40	10	cause	cause	VERB
aiua-13277	40	11	gastrointestinal	gastrointestinal	ADJ
aiua-13277	40	12	disturbances	disturbance	NOUN
aiua-13277	40	13	.	.	PUNCT
aiua-13277	41	1	other	other	ADJ
aiua-13277	41	2	substances	substance	NOUN
aiua-13277	41	3	n	n	CCONJ
aiua-13277	41	4	-	-	PUNCT
aiua-13277	41	5	acetylcysteine	acetylcysteine	NOUN
aiua-13277	41	6	(	(	PUNCT
aiua-13277	41	7	nac	nac	PROPN
aiua-13277	41	8	)	)	PUNCT
aiua-13277	41	9	has	have	AUX
aiua-13277	41	10	been	be	AUX
aiua-13277	41	11	proposed	propose	VERB
aiua-13277	41	12	for	for	ADP
aiua-13277	41	13	its	its	PRON
aiua-13277	41	14	alkalinizing	alkalinizing	NOUN
aiua-13277	41	15	and	and	CCONJ
aiua-13277	41	16	mucolytic	mucolytic	ADJ
aiua-13277	41	17	effect	effect	NOUN
aiua-13277	41	18	due	due	ADP
aiua-13277	41	19	to	to	ADP
aiua-13277	41	20	the	the	DET
aiua-13277	41	21	cleavage	cleavage	NOUN
aiua-13277	41	22	of	of	ADP
aiua-13277	41	23	disulfide	disulfide	NOUN
aiua-13277	41	24	bridges	bridge	NOUN
aiua-13277	41	25	of	of	ADP
aiua-13277	41	26	mucoproteins	mucoprotein	NOUN
aiua-13277	41	27	contained	contain	VERB
aiua-13277	41	28	in	in	ADP
aiua-13277	41	29	the	the	DET
aiua-13277	41	30	deposits	deposit	NOUN
aiua-13277	41	31	of	of	ADP
aiua-13277	41	32	organic	organic	ADJ
aiua-13277	41	33	matter	matter	NOUN
aiua-13277	41	34	covering	cover	VERB
aiua-13277	41	35	stone	stone	NOUN
aiua-13277	41	36	crystals	crystal	NOUN
aiua-13277	41	37	(	(	PUNCT
aiua-13277	41	38	21	21	NUM
aiua-13277	41	39	,	,	PUNCT
aiua-13277	41	40	22	22	NUM
aiua-13277	41	41	)	)	PUNCT
aiua-13277	41	42	.	.	PUNCT
aiua-13277	42	1	in	in	ADP
aiua-13277	42	2	vitro	vitro	X
aiua-13277	42	3	studies	study	NOUN
aiua-13277	42	4	suggested	suggest	VERB
aiua-13277	42	5	the	the	DET
aiua-13277	42	6	use	use	NOUN
aiua-13277	42	7	of	of	ADP
aiua-13277	42	8	some	some	DET
aiua-13277	42	9	glycosaminoglycans	glycosaminoglycan	NOUN
aiua-13277	42	10	,	,	PUNCT
aiua-13277	42	11	glycoproteins	glycoprotein	NOUN
aiua-13277	42	12	and	and	CCONJ
aiua-13277	42	13	saponins	saponin	NOUN
aiua-13277	42	14	(	(	PUNCT
aiua-13277	42	15	such	such	ADJ
aiua-13277	42	16	as	as	ADP
aiua-13277	42	17	ginseng	ginseng	NOUN
aiua-13277	42	18	extract	extract	NOUN
aiua-13277	42	19	)	)	PUNCT
aiua-13277	42	20	to	to	PART
aiua-13277	42	21	interfere	interfere	VERB
aiua-13277	42	22	with	with	ADP
aiua-13277	42	23	crystallization	crystallization	NOUN
aiua-13277	42	24	of	of	ADP
aiua-13277	42	25	uric	uric	ADJ
aiua-13277	42	26	acid	acid	NOUN
aiua-13277	42	27	(	(	PUNCT
aiua-13277	42	28	23	23	NUM
aiua-13277	42	29	)	)	PUNCT
aiua-13277	42	30	.	.	PUNCT
aiua-13277	43	1	however	however	ADV
aiua-13277	43	2	,	,	PUNCT
aiua-13277	43	3	these	these	DET
aiua-13277	43	4	substances	substance	NOUN
aiua-13277	43	5	are	be	AUX
aiua-13277	43	6	not	not	PART
aiua-13277	43	7	properly	properly	ADV
aiua-13277	43	8	inhibitors	inhibitor	NOUN
aiua-13277	43	9	because	because	SCONJ
aiua-13277	43	10	they	they	PRON
aiua-13277	43	11	act	act	VERB
aiua-13277	43	12	by	by	ADP
aiua-13277	43	13	modifying	modify	VERB
aiua-13277	43	14	the	the	DET
aiua-13277	43	15	surface	surface	NOUN
aiua-13277	43	16	tension	tension	NOUN
aiua-13277	43	17	of	of	ADP
aiua-13277	43	18	water	water	NOUN
aiua-13277	43	19	and	and	CCONJ
aiua-13277	43	20	do	do	AUX
aiua-13277	43	21	not	not	PART
aiua-13277	43	22	show	show	VERB
aiua-13277	43	23	dose	dose	NOUN
aiua-13277	43	24	-	-	PUNCT
aiua-13277	43	25	response	response	NOUN
aiua-13277	43	26	relationships	relationship	NOUN
aiua-13277	43	27	.	.	PUNCT
aiua-13277	44	1	theobromine	theobromine	NOUN
aiua-13277	44	2	more	more	ADV
aiua-13277	44	3	recently	recently	ADV
aiua-13277	44	4	,	,	PUNCT
aiua-13277	44	5	in	in	ADP
aiua-13277	44	6	vitro	vitro	X
aiua-13277	44	7	studies	study	NOUN
aiua-13277	44	8	showed	show	VERB
aiua-13277	44	9	that	that	SCONJ
aiua-13277	44	10	theobromine	theobromine	NOUN
aiua-13277	44	11	is	be	AUX
aiua-13277	44	12	a	a	DET
aiua-13277	44	13	very	very	ADV
aiua-13277	44	14	effective	effective	ADJ
aiua-13277	44	15	inhibitor	inhibitor	NOUN
aiua-13277	44	16	of	of	ADP
aiua-13277	44	17	uric	uric	ADJ
aiua-13277	44	18	acid	acid	NOUN
aiua-13277	44	19	crystallization	crystallization	NOUN
aiua-13277	44	20	(	(	PUNCT
aiua-13277	44	21	24	24	NUM
aiua-13277	44	22	,	,	PUNCT
aiua-13277	44	23	25	25	NUM
aiua-13277	44	24	)	)	PUNCT
aiua-13277	44	25	.	.	PUNCT
aiua-13277	45	1	this	this	DET
aiua-13277	45	2	effect	effect	NOUN
aiua-13277	45	3	is	be	AUX
aiua-13277	45	4	clinically	clinically	ADV
aiua-13277	45	5	significant	significant	ADJ
aiua-13277	45	6	for	for	ADP
aiua-13277	45	7	urinary	urinary	ADJ
aiua-13277	45	8	concentration	concentration	NOUN
aiua-13277	45	9	over	over	ADP
aiua-13277	45	10	15	15	NUM
aiua-13277	45	11	mg	mg	NUM
aiua-13277	45	12	/	/	SYM
aiua-13277	45	13	l	l	NOUN
aiua-13277	45	14	or	or	CCONJ
aiua-13277	45	15	higher	high	ADJ
aiua-13277	45	16	,	,	PUNCT
aiua-13277	45	17	although	although	SCONJ
aiua-13277	45	18	higher	high	ADJ
aiua-13277	45	19	concentrations	concentration	NOUN
aiua-13277	45	20	(	(	PUNCT
aiua-13277	45	21	80	80	NUM
aiua-13277	45	22	mg	mg	PROPN
aiua-13277	45	23	/	/	SYM
aiua-13277	45	24	l	l	NOUN
aiua-13277	45	25	)	)	PUNCT
aiua-13277	45	26	provided	provide	VERB
aiua-13277	45	27	no	no	DET
aiua-13277	45	28	additional	additional	ADJ
aiua-13277	45	29	benefit	benefit	NOUN
aiua-13277	45	30	.	.	PUNCT
aiua-13277	46	1	urinary	urinary	ADJ
aiua-13277	46	2	concentrations	concentration	NOUN
aiua-13277	46	3	in	in	ADP
aiua-13277	46	4	the	the	DET
aiua-13277	46	5	therapeutical	therapeutical	ADJ
aiua-13277	46	6	range	range	NOUN
aiua-13277	46	7	are	be	AUX
aiua-13277	46	8	obtained	obtain	VERB
aiua-13277	46	9	after	after	ADP
aiua-13277	46	10	oral	oral	ADJ
aiua-13277	46	11	administration	administration	NOUN
aiua-13277	46	12	of	of	ADP
aiua-13277	46	13	300	300	NUM
aiua-13277	46	14	mg	mg	NOUN
aiua-13277	46	15	of	of	ADP
aiua-13277	46	16	theobromine	theobromine	NOUN
aiua-13277	46	17	with	with	ADP
aiua-13277	46	18	approximately	approximately	ADV
aiua-13277	46	19	60	60	NUM
aiua-13277	46	20	mg	mg	NOUN
aiua-13277	46	21	excreted	excrete	VERB
aiua-13277	46	22	unchanged	unchanged	ADJ
aiua-13277	46	23	in	in	ADP
aiua-13277	46	24	the	the	DET
aiua-13277	46	25	urine	urine	NOUN
aiua-13277	46	26	.	.	PUNCT
aiua-13277	47	1	caffeine	caffeine	NOUN
aiua-13277	47	2	,	,	PUNCT
aiua-13277	47	3	theophylline	theophylline	NOUN
aiua-13277	47	4	and	and	CCONJ
aiua-13277	47	5	paraxanthine	paraxanthine	NOUN
aiua-13277	47	6	showed	show	VERB
aiua-13277	47	7	no	no	DET
aiua-13277	47	8	similar	similar	ADJ
aiua-13277	47	9	effects	effect	NOUN
aiua-13277	47	10	.	.	PUNCT
aiua-13277	48	1	in	in	ADP
aiua-13277	48	2	fact	fact	NOUN
aiua-13277	48	3	,	,	PUNCT
aiua-13277	48	4	they	they	PRON
aiua-13277	48	5	had	have	VERB
aiua-13277	48	6	a	a	DET
aiua-13277	48	7	structure	structure	NOUN
aiua-13277	48	8	very	very	ADV
aiua-13277	48	9	similar	similar	ADJ
aiua-13277	48	10	to	to	ADP
aiua-13277	48	11	theobromine	theobromine	NOUN
aiua-13277	48	12	,	,	PUNCT
aiua-13277	48	13	but	but	CCONJ
aiua-13277	48	14	minimal	minimal	ADJ
aiua-13277	48	15	modification	modification	NOUN
aiua-13277	48	16	of	of	ADP
aiua-13277	48	17	their	their	PRON
aiua-13277	48	18	chemical	chemical	NOUN
aiua-13277	48	19	structure	structure	NOUN
aiua-13277	48	20	makes	make	VERB
aiua-13277	48	21	them	they	PRON
aiua-13277	48	22	ineffective	ineffective	ADJ
aiua-13277	48	23	as	as	ADP
aiua-13277	48	24	inhibitors	inhibitor	NOUN
aiua-13277	48	25	.	.	PUNCT
aiua-13277	49	1	theobromine	theobromine	NOUN
aiua-13277	49	2	inhibits	inhibit	VERB
aiua-13277	49	3	nucleation	nucleation	NOUN
aiua-13277	49	4	of	of	ADP
aiua-13277	49	5	uric	uric	ADJ
aiua-13277	49	6	acid	acid	NOUN
aiua-13277	49	7	crystals	crystal	NOUN
aiua-13277	49	8	being	be	AUX
aiua-13277	49	9	absorbed	absorb	VERB
aiua-13277	49	10	onto	onto	ADP
aiua-13277	49	11	the	the	DET
aiua-13277	49	12	faces	face	NOUN
aiua-13277	49	13	of	of	ADP
aiua-13277	49	14	the	the	DET
aiua-13277	49	15	crystals	crystal	NOUN
aiua-13277	49	16	and	and	CCONJ
aiua-13277	49	17	modifying	modify	VERB
aiua-13277	49	18	their	their	PRON
aiua-13277	49	19	morphology	morphology	NOUN
aiua-13277	49	20	making	make	VERB
aiua-13277	49	21	them	they	PRON
aiua-13277	49	22	longer	long	ADJ
aiua-13277	49	23	and	and	CCONJ
aiua-13277	49	24	thinner	thin	ADJ
aiua-13277	49	25	.	.	PUNCT
aiua-13277	50	1	in	in	ADP
aiua-13277	50	2	particular	particular	ADJ
aiua-13277	50	3	,	,	PUNCT
aiua-13277	50	4	theobromine	theobromine	NOUN
aiua-13277	50	5	may	may	AUX
aiua-13277	50	6	inhibit	inhibit	VERB
aiua-13277	50	7	growth	growth	NOUN
aiua-13277	50	8	at	at	ADP
aiua-13277	50	9	only	only	ADV
aiua-13277	50	10	one	one	NUM
aiua-13277	50	11	of	of	ADP
aiua-13277	50	12	the	the	DET
aiua-13277	50	13	faces	face	NOUN
aiua-13277	50	14	of	of	ADP
aiua-13277	50	15	the	the	DET
aiua-13277	50	16	crystal	crystal	NOUN
aiua-13277	50	17	(	(	PUNCT
aiua-13277	50	18	210	210	NUM
aiua-13277	50	19	)	)	PUNCT
aiua-13277	50	20	,	,	PUNCT
aiua-13277	50	21	but	but	CCONJ
aiua-13277	50	22	not	not	PART
aiua-13277	50	23	at	at	ADP
aiua-13277	50	24	the	the	DET
aiua-13277	50	25	others	other	NOUN
aiua-13277	50	26	(	(	PUNCT
aiua-13277	50	27	001	001	NUM
aiua-13277	50	28	and	and	CCONJ
aiua-13277	50	29	201	201	NUM
aiua-13277	50	30	)	)	PUNCT
aiua-13277	50	31	.	.	PUNCT
aiua-13277	51	1	because	because	SCONJ
aiua-13277	51	2	uric	uric	ADJ
aiua-13277	51	3	acid	acid	NOUN
aiua-13277	51	4	and	and	CCONJ
aiua-13277	51	5	theobromine	theobromine	ADJ
aiua-13277	51	6	molecules	molecule	NOUN
aiua-13277	51	7	have	have	VERB
aiua-13277	51	8	very	very	ADV
aiua-13277	51	9	similar	similar	ADJ
aiua-13277	51	10	structural	structural	ADJ
aiua-13277	51	11	patterns	pattern	NOUN
aiua-13277	51	12	,	,	PUNCT
aiua-13277	51	13	theobromine	theobromine	NOUN
aiua-13277	51	14	can	can	AUX
aiua-13277	51	15	substitute	substitute	VERB
aiua-13277	51	16	uric	uric	ADJ
aiua-13277	51	17	acid	acid	NOUN
aiua-13277	51	18	molecules	molecule	NOUN
aiua-13277	51	19	in	in	ADP
aiua-13277	51	20	the	the	DET
aiua-13277	51	21	corresponding	corresponding	ADJ
aiua-13277	51	22	uric	uric	ADJ
aiua-13277	51	23	acid	acid	NOUN
aiua-13277	51	24	crystals	crystal	NOUN
aiua-13277	51	25	.	.	PUNCT
aiua-13277	52	1	the	the	DET
aiua-13277	52	2	incorporation	incorporation	NOUN
aiua-13277	52	3	of	of	ADP
aiua-13277	52	4	this	this	DET
aiua-13277	52	5	molecule	molecule	NOUN
aiua-13277	52	6	to	to	ADP
aiua-13277	52	7	the	the	DET
aiua-13277	52	8	uric	uric	ADJ
aiua-13277	52	9	acid	acid	PROPN
aiua-13277	52	10	crystal	crystal	PROPN
aiua-13277	52	11	lattice	lattice	PROPN
aiua-13277	52	12	modifies	modify	VERB
aiua-13277	52	13	the	the	DET
aiua-13277	52	14	structure	structure	NOUN
aiua-13277	52	15	of	of	ADP
aiua-13277	52	16	some	some	DET
aiua-13277	52	17	layers	layer	NOUN
aiua-13277	52	18	so	so	ADV
aiua-13277	52	19	increasing	increase	VERB
aiua-13277	52	20	their	their	PRON
aiua-13277	52	21	energy	energy	NOUN
aiua-13277	52	22	and	and	CCONJ
aiua-13277	52	23	decreasing	decrease	VERB
aiua-13277	52	24	their	their	PRON
aiua-13277	52	25	growth	growth	NOUN
aiua-13277	52	26	rate	rate	NOUN
aiua-13277	52	27	.	.	PUNCT
aiua-13277	53	1	in	in	ADP
aiua-13277	53	2	the	the	DET
aiua-13277	53	3	presence	presence	NOUN
aiua-13277	53	4	of	of	ADP
aiua-13277	53	5	theobromine	theobromine	ADJ
aiua-13277	53	6	crystals	crystal	NOUN
aiua-13277	53	7	formed	form	VERB
aiua-13277	53	8	on	on	ADP
aiua-13277	53	9	the	the	DET
aiua-13277	53	10	surface	surface	NOUN
aiua-13277	53	11	of	of	ADP
aiua-13277	53	12	the	the	DET
aiua-13277	53	13	uric	uric	ADJ
aiua-13277	53	14	acid	acid	NOUN
aiua-13277	53	15	were	be	AUX
aiua-13277	53	16	smaller	small	ADJ
aiua-13277	53	17	.	.	PUNCT
aiua-13277	54	1	thus	thus	ADV
aiua-13277	54	2	,	,	PUNCT
aiua-13277	54	3	theobromine	theobromine	NOUN
aiua-13277	54	4	may	may	AUX
aiua-13277	54	5	be	be	AUX
aiua-13277	54	6	clinically	clinically	ADV
aiua-13277	54	7	useful	useful	ADJ
aiua-13277	54	8	in	in	ADP
aiua-13277	54	9	preventing	prevent	VERB
aiua-13277	54	10	the	the	DET
aiua-13277	54	11	regrowth	regrowth	NOUN
aiua-13277	54	12	of	of	ADP
aiua-13277	54	13	uric	uric	ADJ
aiua-13277	54	14	acid	acid	ADJ
aiua-13277	54	15	calculi	calculi	PROPN
aiua-13277	54	16	fragments	fragment	NOUN
aiua-13277	54	17	.	.	PUNCT
aiua-13277	55	1	theobromine	theobromine	NOUN
aiua-13277	55	2	also	also	ADV
aiua-13277	55	3	favors	favor	VERB
aiua-13277	55	4	the	the	DET
aiua-13277	55	5	dissolution	dissolution	NOUN
aiua-13277	55	6	of	of	ADP
aiua-13277	55	7	crystals	crystal	NOUN
aiua-13277	55	8	by	by	ADP
aiua-13277	55	9	decreasing	decrease	VERB
aiua-13277	55	10	supersaturation	supersaturation	NOUN
aiua-13277	55	11	of	of	ADP
aiua-13277	55	12	uric	uric	ADJ
aiua-13277	55	13	acid	acid	NOUN
aiua-13277	55	14	(	(	PUNCT
aiua-13277	55	15	26	26	NUM
aiua-13277	55	16	)	)	PUNCT
aiua-13277	55	17	.	.	PUNCT
aiua-13277	56	1	the	the	DET
aiua-13277	56	2	velocity	velocity	NOUN
aiua-13277	56	3	of	of	ADP
aiua-13277	56	4	stone	stone	NOUN
aiua-13277	56	5	dissolution	dissolution	NOUN
aiua-13277	56	6	depends	depend	VERB
aiua-13277	56	7	on	on	ADP
aiua-13277	56	8	the	the	DET
aiua-13277	56	9	size	size	NOUN
aiua-13277	56	10	and	and	CCONJ
aiua-13277	56	11	location	location	NOUN
aiua-13277	56	12	of	of	ADP
aiua-13277	56	13	the	the	DET
aiua-13277	56	14	stone	stone	NOUN
aiua-13277	56	15	and	and	CCONJ
aiua-13277	56	16	on	on	ADP
aiua-13277	56	17	flow	flow	NOUN
aiua-13277	56	18	of	of	ADP
aiua-13277	56	19	irrigation	irrigation	NOUN
aiua-13277	56	20	.	.	PUNCT
aiua-13277	57	1	furthermore	furthermore	ADV
aiua-13277	57	2	,	,	PUNCT
aiua-13277	57	3	the	the	DET
aiua-13277	57	4	microstructure	microstructure	NOUN
aiua-13277	57	5	of	of	ADP
aiua-13277	57	6	the	the	DET
aiua-13277	57	7	stone	stone	NOUN
aiua-13277	57	8	,	,	PUNCT
aiua-13277	57	9	as	as	SCONJ
aiua-13277	57	10	observed	observe	VERB
aiua-13277	57	11	at	at	ADP
aiua-13277	57	12	scanning	scan	VERB
aiua-13277	57	13	electronic	electronic	ADJ
aiua-13277	57	14	microscopy	microscopy	NOUN
aiua-13277	57	15	can	can	AUX
aiua-13277	57	16	influence	influence	VERB
aiua-13277	57	17	the	the	DET
aiua-13277	57	18	process	process	NOUN
aiua-13277	57	19	of	of	ADP
aiua-13277	57	20	dissolution	dissolution	NOUN
aiua-13277	57	21	.	.	PUNCT
aiua-13277	58	1	in	in	ADP
aiua-13277	58	2	fact	fact	NOUN
aiua-13277	58	3	,	,	PUNCT
aiua-13277	58	4	stones	stone	NOUN
aiua-13277	58	5	that	that	PRON
aiua-13277	58	6	appeared	appear	VERB
aiua-13277	58	7	macroscopically	macroscopically	ADV
aiua-13277	58	8	similar	similar	ADJ
aiua-13277	58	9	,	,	PUNCT
aiua-13277	58	10	may	may	AUX
aiua-13277	58	11	have	have	VERB
aiua-13277	58	12	major	major	ADJ
aiua-13277	58	13	differences	difference	NOUN
aiua-13277	58	14	in	in	ADP
aiua-13277	58	15	microstructure	microstructure	NOUN
aiua-13277	58	16	by	by	ADP
aiua-13277	58	17	the	the	DET
aiua-13277	58	18	presence	presence	NOUN
aiua-13277	58	19	of	of	ADP
aiua-13277	58	20	porosities	porosity	NOUN
aiua-13277	58	21	,	,	PUNCT
aiua-13277	58	22	the	the	DET
aiua-13277	58	23	distribution	distribution	NOUN
aiua-13277	58	24	of	of	ADP
aiua-13277	58	25	organic	organic	ADJ
aiua-13277	58	26	matter	matter	NOUN
aiua-13277	58	27	and	and	CCONJ
aiua-13277	58	28	the	the	DET
aiua-13277	58	29	size	size	NOUN
aiua-13277	58	30	of	of	ADP
aiua-13277	58	31	crystals	crystal	NOUN
aiua-13277	58	32	.	.	PUNCT
aiua-13277	59	1	the	the	DET
aiua-13277	59	2	dissolution	dissolution	NOUN
aiua-13277	59	3	can	can	AUX
aiua-13277	59	4	be	be	AUX
aiua-13277	59	5	made	make	VERB
aiua-13277	59	6	difficult	difficult	ADJ
aiua-13277	59	7	by	by	ADP
aiua-13277	59	8	the	the	DET
aiua-13277	59	9	presence	presence	NOUN
aiua-13277	59	10	of	of	ADP
aiua-13277	59	11	shells	shell	NOUN
aiua-13277	59	12	of	of	ADP
aiua-13277	59	13	sodium	sodium	NOUN
aiua-13277	59	14	/	/	SYM
aiua-13277	59	15	potassium	potassium	NOUN
aiua-13277	59	16	urate	urate	NOUN
aiua-13277	59	17	or	or	CCONJ
aiua-13277	59	18	apatite	apatite	NOUN
aiua-13277	59	19	as	as	ADP
aiua-13277	59	20	consequence	consequence	NOUN
aiua-13277	59	21	of	of	ADP
aiua-13277	59	22	very	very	ADV
aiua-13277	59	23	high	high	ADJ
aiua-13277	59	24	ph	ph	NOUN
aiua-13277	59	25	(	(	PUNCT
aiua-13277	59	26	above	above	ADP
aiua-13277	59	27	7	7	NUM
aiua-13277	59	28	)	)	PUNCT
aiua-13277	59	29	and	and	CCONJ
aiua-13277	59	30	high	high	ADJ
aiua-13277	59	31	uric	uric	ADJ
aiua-13277	59	32	acid	acid	NOUN
aiua-13277	59	33	concentration	concentration	NOUN
aiua-13277	59	34	(	(	PUNCT
aiua-13277	59	35	27	27	NUM
aiua-13277	59	36	)	)	PUNCT
aiua-13277	59	37	.	.	PUNCT
aiua-13277	60	1	combined	combine	VERB
aiua-13277	60	2	treatment	treatment	NOUN
aiua-13277	60	3	the	the	DET
aiua-13277	60	4	combination	combination	NOUN
aiua-13277	60	5	of	of	ADP
aiua-13277	60	6	alkalization	alkalization	NOUN
aiua-13277	60	7	with	with	ADP
aiua-13277	60	8	citrate	citrate	NOUN
aiua-13277	60	9	and	and	CCONJ
aiua-13277	60	10	theobromine	theobromine	NOUN
aiua-13277	60	11	patented	patent	VERB
aiua-13277	60	12	and	and	CCONJ
aiua-13277	60	13	commercialized	commercialize	VERB
aiua-13277	60	14	by	by	ADP
aiua-13277	60	15	the	the	DET
aiua-13277	60	16	company	company	NOUN
aiua-13277	60	17	devicare	devicare	VERB
aiua-13277	60	18	in	in	ADP
aiua-13277	60	19	its	its	PRON
aiua-13277	60	20	lit	light	VERB
aiua-13277	60	21	-	-	PUNCT
aiua-13277	60	22	control	control	NOUN
aiua-13277	60	23	ph	ph	VERB
aiua-13277	60	24	up	up	ADJ
aiua-13277	60	25	treatment	treatment	NOUN
aiua-13277	60	26	(	(	PUNCT
aiua-13277	60	27	28	28	NUM
aiua-13277	60	28	,	,	PUNCT
aiua-13277	60	29	29	29	NUM
aiua-13277	60	30	)	)	PUNCT
aiua-13277	60	31	,	,	PUNCT
aiua-13277	60	32	allows	allow	VERB
aiua-13277	60	33	to	to	PART
aiua-13277	60	34	use	use	VERB
aiua-13277	60	35	lower	low	ADJ
aiua-13277	60	36	doses	dose	NOUN
aiua-13277	60	37	of	of	ADP
aiua-13277	60	38	citrate	citrate	NOUN
aiua-13277	60	39	,	,	PUNCT
aiua-13277	60	40	thus	thus	ADV
aiua-13277	60	41	preventing	prevent	VERB
aiua-13277	60	42	excessive	excessive	ADJ
aiua-13277	60	43	alkalinization	alkalinization	NOUN
aiua-13277	60	44	to	to	PART
aiua-13277	60	45	avoid	avoid	VERB
aiua-13277	60	46	formation	formation	NOUN
aiua-13277	60	47	of	of	ADP
aiua-13277	60	48	sodium	sodium	NOUN
aiua-13277	60	49	urate	urate	NOUN
aiua-13277	60	50	crystals	crystal	NOUN
aiua-13277	60	51	(	(	PUNCT
aiua-13277	60	52	30	30	NUM
aiua-13277	60	53	)	)	PUNCT
aiua-13277	60	54	.	.	PUNCT
aiua-13277	61	1	furthermore	furthermore	ADV
aiua-13277	61	2	,	,	PUNCT
aiua-13277	61	3	the	the	DET
aiua-13277	61	4	reduced	reduced	ADJ
aiua-13277	61	5	dose	dose	NOUN
aiua-13277	61	6	of	of	ADP
aiua-13277	61	7	potassium	potassium	NOUN
aiua-13277	61	8	citrate	citrate	NOUN
aiua-13277	61	9	administration	administration	NOUN
aiua-13277	61	10	decreases	decrease	VERB
aiua-13277	61	11	the	the	DET
aiua-13277	61	12	risk	risk	NOUN
aiua-13277	61	13	of	of	ADP
aiua-13277	61	14	hyperkaliemia	hyperkaliemia	NOUN
aiua-13277	61	15	in	in	ADP
aiua-13277	61	16	patients	patient	NOUN
aiua-13277	61	17	with	with	ADP
aiua-13277	61	18	kidney	kidney	NOUN
aiua-13277	61	19	failure	failure	NOUN
aiua-13277	61	20	or	or	CCONJ
aiua-13277	61	21	heart	heart	NOUN
aiua-13277	61	22	disease	disease	NOUN
aiua-13277	61	23	.	.	PUNCT
aiua-13277	62	1	theobromine	theobromine	NOUN
aiua-13277	62	2	and	and	CCONJ
aiua-13277	62	3	xanthinuria	xanthinuria	NOUN
aiua-13277	62	4	xanthinuria	xanthinuria	PROPN
aiua-13277	62	5	is	be	AUX
aiua-13277	62	6	a	a	DET
aiua-13277	62	7	rare	rare	ADJ
aiua-13277	62	8	hereditary	hereditary	ADJ
aiua-13277	62	9	disorder	disorder	NOUN
aiua-13277	62	10	related	relate	VERB
aiua-13277	62	11	to	to	ADP
aiua-13277	62	12	a	a	DET
aiua-13277	62	13	deficiency	deficiency	NOUN
aiua-13277	62	14	of	of	ADP
aiua-13277	62	15	xanthine	xanthine	NOUN
aiua-13277	62	16	dehydrogenase	dehydrogenase	NOUN
aiua-13277	62	17	/	/	SYM
aiua-13277	62	18	oxidase	oxidase	NOUN
aiua-13277	62	19	(	(	PUNCT
aiua-13277	62	20	xdh	xdh	PROPN
aiua-13277	62	21	/	/	SYM
aiua-13277	62	22	ox	ox	NOUN
aiua-13277	62	23	)	)	PUNCT
aiua-13277	62	24	causing	cause	VERB
aiua-13277	62	25	an	an	DET
aiua-13277	62	26	accumulation	accumulation	NOUN
aiua-13277	62	27	of	of	ADP
aiua-13277	62	28	hypoxanthine	hypoxanthine	NOUN
aiua-13277	62	29	and	and	CCONJ
aiua-13277	62	30	xanthine	xanthine	NOUN
aiua-13277	62	31	due	due	ADP
aiua-13277	62	32	to	to	ADP
aiua-13277	62	33	a	a	DET
aiua-13277	62	34	reduced	reduce	VERB
aiua-13277	62	35	degradation	degradation	NOUN
aiua-13277	62	36	of	of	ADP
aiua-13277	62	37	these	these	DET
aiua-13277	62	38	two	two	NUM
aiua-13277	62	39	precursors	precursor	NOUN
aiua-13277	62	40	to	to	ADP
aiua-13277	62	41	uric	uric	ADJ
aiua-13277	62	42	acid	acid	NOUN
aiua-13277	62	43	.	.	PUNCT
aiua-13277	63	1	this	this	DET
aiua-13277	63	2	results	result	VERB
aiua-13277	63	3	in	in	ADP
aiua-13277	63	4	hypouricemia	hypouricemia	PROPN
aiua-13277	63	5	,	,	PUNCT
aiua-13277	63	6	hypouricosuria	hypouricosuria	PROPN
aiua-13277	63	7	,	,	PUNCT
aiua-13277	63	8	xanthinuria	xanthinuria	NOUN
aiua-13277	63	9	and	and	CCONJ
aiua-13277	63	10	formation	formation	NOUN
aiua-13277	63	11	of	of	ADP
aiua-13277	63	12	xanthine	xanthine	NOUN
aiua-13277	63	13	urinary	urinary	ADJ
aiua-13277	63	14	stones	stone	NOUN
aiua-13277	63	15	(	(	PUNCT
aiua-13277	63	16	31	31	NUM
aiua-13277	63	17	,	,	PUNCT
aiua-13277	63	18	32	32	NUM
aiua-13277	63	19	)	)	PUNCT
aiua-13277	63	20	.	.	PUNCT
aiua-13277	64	1	there	there	PRON
aiua-13277	64	2	are	be	VERB
aiua-13277	64	3	different	different	ADJ
aiua-13277	64	4	types	type	NOUN
aiua-13277	64	5	of	of	ADP
aiua-13277	64	6	xanthinuria	xanthinuria	NOUN
aiua-13277	64	7	due	due	ADP
aiua-13277	64	8	to	to	ADP
aiua-13277	64	9	mutations	mutation	NOUN
aiua-13277	64	10	of	of	ADP
aiua-13277	64	11	different	different	ADJ
aiua-13277	64	12	genes	gene	NOUN
aiua-13277	64	13	(	(	PUNCT
aiua-13277	64	14	33	33	NUM
aiua-13277	64	15	-	-	SYM
aiua-13277	64	16	35	35	NUM
aiua-13277	64	17	)	)	PUNCT
aiua-13277	64	18	.	.	PUNCT
aiua-13277	65	1	the	the	DET
aiua-13277	65	2	classical	classical	ADJ
aiua-13277	65	3	type	type	NOUN
aiua-13277	65	4	i	i	PRON
aiua-13277	65	5	is	be	AUX
aiua-13277	65	6	caused	cause	VERB
aiua-13277	65	7	by	by	ADP
aiua-13277	65	8	a	a	DET
aiua-13277	65	9	mutation	mutation	NOUN
aiua-13277	65	10	in	in	ADP
aiua-13277	65	11	xdh	xdh	PROPN
aiua-13277	65	12	/	/	SYM
aiua-13277	65	13	xo	xo	PROPN
aiua-13277	65	14	gene	gene	PROPN
aiua-13277	65	15	mapped	map	VERB
aiua-13277	65	16	to	to	PART
aiua-13277	65	17	chromosome	chromosome	VERB
aiua-13277	65	18	2p23.1	2p23.1	NUM
aiua-13277	65	19	.	.	PUNCT
aiua-13277	66	1	type	type	NOUN
aiua-13277	66	2	ii	ii	PROPN
aiua-13277	66	3	depends	depend	VERB
aiua-13277	66	4	on	on	ADP
aiua-13277	66	5	mutations	mutation	NOUN
aiua-13277	66	6	in	in	ADP
aiua-13277	66	7	molybdenum	molybdenum	NOUN
aiua-13277	66	8	cofactor	cofactor	NOUN
aiua-13277	66	9	sulfurase	sulfurase	NOUN
aiua-13277	66	10	gene	gene	NOUN
aiua-13277	66	11	(	(	PUNCT
aiua-13277	66	12	mocos	mocos	PROPN
aiua-13277	66	13	)	)	PUNCT
aiua-13277	66	14	localized	localize	VERB
aiua-13277	66	15	on	on	ADP
aiua-13277	66	16	chromosome	chromosome	NOUN
aiua-13277	66	17	18q12.2	18q12.2	NUM
aiua-13277	66	18	that	that	PRON
aiua-13277	66	19	cause	cause	VERB
aiua-13277	66	20	a	a	DET
aiua-13277	66	21	defect	defect	NOUN
aiua-13277	66	22	of	of	ADP
aiua-13277	66	23	xdh	xdh	PROPN
aiua-13277	66	24	/	/	SYM
aiua-13277	66	25	ox	ox	NOUN
aiua-13277	66	26	and	and	CCONJ
aiua-13277	66	27	aldehyde	aldehyde	NOUN
aiua-13277	66	28	oxidase	oxidase	NOUN
aiua-13277	66	29	(	(	PUNCT
aiua-13277	66	30	ao	ao	PROPN
aiua-13277	66	31	)	)	PUNCT
aiua-13277	66	32	.	.	PUNCT
aiua-13277	67	1	triple	triple	ADJ
aiua-13277	67	2	deficiency	deficiency	NOUN
aiua-13277	67	3	of	of	ADP
aiua-13277	67	4	xdh	xdh	PROPN
aiua-13277	67	5	,	,	PUNCT
aiua-13277	67	6	aox	aox	PROPN
aiua-13277	67	7	and	and	CCONJ
aiua-13277	67	8	sulfite	sulfite	NOUN
aiua-13277	67	9	oxidase	oxidase	NOUN
aiua-13277	67	10	is	be	AUX
aiua-13277	67	11	caused	cause	VERB
aiua-13277	67	12	by	by	ADP
aiua-13277	67	13	molybdenum	molybdenum	NOUN
aiua-13277	67	14	cofactor	cofactor	NOUN
aiua-13277	67	15	deficiency	deficiency	NOUN
aiua-13277	67	16	type	type	NOUN
aiua-13277	67	17	a	a	DET
aiua-13277	67	18	(	(	PUNCT
aiua-13277	67	19	omim	omim	PROPN
aiua-13277	67	20	252150	252150	NUM
aiua-13277	67	21	)	)	PUNCT
aiua-13277	67	22	due	due	ADP
aiua-13277	67	23	to	to	ADP
aiua-13277	67	24	mutations	mutation	NOUN
aiua-13277	67	25	in	in	ADP
aiua-13277	67	26	mocs1	mocs1	PROPN
aiua-13277	67	27	gene	gene	NOUN
aiua-13277	67	28	(	(	PUNCT
aiua-13277	67	29	6p21.1	6p21.1	NOUN
aiua-13277	67	30	)	)	PUNCT
aiua-13277	67	31	.	.	PUNCT
aiua-13277	68	1	the	the	DET
aiua-13277	68	2	classical	classical	ADJ
aiua-13277	68	3	presentation	presentation	NOUN
aiua-13277	68	4	occurs	occur	VERB
aiua-13277	68	5	at	at	ADP
aiua-13277	68	6	any	any	DET
aiua-13277	68	7	age	age	NOUN
aiua-13277	68	8	with	with	ADP
aiua-13277	68	9	renal	renal	ADJ
aiua-13277	68	10	colic	colic	NOUN
aiua-13277	68	11	,	,	PUNCT
aiua-13277	68	12	hematuria	hematuria	NOUN
aiua-13277	68	13	and	and	CCONJ
aiua-13277	68	14	urinary	urinary	ADJ
aiua-13277	68	15	tract	tract	NOUN
aiua-13277	68	16	infection	infection	NOUN
aiua-13277	68	17	associated	associate	VERB
aiua-13277	68	18	to	to	ADP
aiua-13277	68	19	xanthine	xanthine	NOUN
aiua-13277	68	20	stones	stone	NOUN
aiua-13277	68	21	.	.	PUNCT
aiua-13277	69	1	less	less	ADV
aiua-13277	69	2	frequently	frequently	ADV
aiua-13277	69	3	the	the	DET
aiua-13277	69	4	presentation	presentation	NOUN
aiua-13277	69	5	is	be	AUX
aiua-13277	69	6	more	more	ADV
aiua-13277	69	7	severe	severe	ADJ
aiua-13277	69	8	with	with	ADP
aiua-13277	69	9	renal	renal	ADJ
aiua-13277	69	10	failure	failure	NOUN
aiua-13277	69	11	,	,	PUNCT
aiua-13277	69	12	muscle	muscle	NOUN
aiua-13277	69	13	-	-	PUNCT
aiua-13277	69	14	skeletal	skeletal	ADJ
aiua-13277	69	15	and	and	CCONJ
aiua-13277	69	16	gastrointestinal	gastrointestinal	ADJ
aiua-13277	69	17	symptoms	symptom	NOUN
aiua-13277	69	18	.	.	PUNCT
aiua-13277	70	1	traditional	traditional	ADJ
aiua-13277	70	2	diagnosis	diagnosis	NOUN
aiua-13277	70	3	with	with	ADP
aiua-13277	70	4	allopurinol	allopurinol	NOUN
aiua-13277	70	5	loading	loading	NOUN
aiua-13277	70	6	test	test	NOUN
aiua-13277	70	7	or	or	CCONJ
aiua-13277	70	8	liver	liver	NOUN
aiua-13277	70	9	biopsy	biopsy	NOUN
aiua-13277	70	10	has	have	AUX
aiua-13277	70	11	been	be	AUX
aiua-13277	70	12	replaced	replace	VERB
aiua-13277	70	13	by	by	ADP
aiua-13277	70	14	genetic	genetic	ADJ
aiua-13277	70	15	testing	testing	NOUN
aiua-13277	70	16	in	in	ADP
aiua-13277	70	17	stone	stone	NOUN
aiua-13277	70	18	patients	patient	NOUN
aiua-13277	70	19	with	with	ADP
aiua-13277	70	20	extremely	extremely	ADV
aiua-13277	70	21	low	low	ADJ
aiua-13277	70	22	serum	serum	NOUN
aiua-13277	70	23	and	and	CCONJ
aiua-13277	70	24	low	low	ADJ
aiua-13277	70	25	urinary	urinary	ADJ
aiua-13277	70	26	uric	uric	ADJ
aiua-13277	70	27	acid	acid	NOUN
aiua-13277	70	28	replaced	replace	VERB
aiua-13277	70	29	by	by	ADP
aiua-13277	70	30	xanthine	xanthine	NOUN
aiua-13277	70	31	.	.	PUNCT
aiua-13277	71	1	the	the	DET
aiua-13277	71	2	treatment	treatment	NOUN
aiua-13277	71	3	for	for	ADP
aiua-13277	71	4	patients	patient	NOUN
aiua-13277	71	5	with	with	ADP
aiua-13277	71	6	xanthinuria	xanthinuria	NOUN
aiua-13277	71	7	is	be	AUX
aiua-13277	71	8	a	a	DET
aiua-13277	71	9	low	low	ADJ
aiua-13277	71	10	purine	purine	NOUN
aiua-13277	71	11	diet	diet	NOUN
aiua-13277	71	12	and	and	CCONJ
aiua-13277	71	13	high	high	ADJ
aiua-13277	71	14	intake	intake	NOUN
aiua-13277	71	15	of	of	ADP
aiua-13277	71	16	fluids	fluid	NOUN
aiua-13277	71	17	.	.	PUNCT
aiua-13277	72	1	in	in	ADP
aiua-13277	72	2	contrast	contrast	NOUN
aiua-13277	72	3	to	to	ADP
aiua-13277	72	4	patients	patient	NOUN
aiua-13277	72	5	with	with	ADP
aiua-13277	72	6	uric	uric	ADJ
aiua-13277	72	7	acid	acid	NOUN
aiua-13277	72	8	stones	stone	NOUN
aiua-13277	72	9	,	,	PUNCT
aiua-13277	72	10	urine	urine	NOUN
aiua-13277	72	11	alkalinization	alkalinization	NOUN
aiua-13277	72	12	is	be	AUX
aiua-13277	72	13	not	not	PART
aiua-13277	72	14	effective	effective	ADJ
aiua-13277	72	15	because	because	SCONJ
aiua-13277	72	16	the	the	DET
aiua-13277	72	17	solubility	solubility	NOUN
aiua-13277	72	18	of	of	ADP
aiua-13277	72	19	xanthine	xanthine	NOUN
aiua-13277	72	20	is	be	AUX
aiua-13277	72	21	relatively	relatively	ADV
aiua-13277	72	22	independent	independent	ADJ
aiua-13277	72	23	of	of	ADP
aiua-13277	72	24	urinary	urinary	ADJ
aiua-13277	72	25	ph	ph	PROPN
aiua-13277	72	26	.	.	PUNCT
aiua-13277	73	1	a	a	DET
aiua-13277	73	2	recent	recent	ADJ
aiua-13277	73	3	study	study	NOUN
aiua-13277	73	4	showed	show	VERB
aiua-13277	73	5	that	that	SCONJ
aiua-13277	73	6	1	1	NUM
aiua-13277	73	7	-	-	NUM
aiua-13277	73	8	methylxanthine	methylxanthine	ADJ
aiua-13277	73	9	(	(	PUNCT
aiua-13277	73	10	1	1	NUM
aiua-13277	73	11	-	-	PUNCT
aiua-13277	73	12	mx	mx	NOUN
aiua-13277	73	13	)	)	PUNCT
aiua-13277	73	14	,	,	PUNCT
aiua-13277	73	15	7	7	NUM
aiua-13277	73	16	-	-	PUNCT
aiua-13277	73	17	methylxanthine	methylxanthine	ADJ
aiua-13277	73	18	(	(	PUNCT
aiua-13277	73	19	7	7	NUM
aiua-13277	73	20	-	-	PUNCT
aiua-13277	73	21	mx	mx	NOUN
aiua-13277	73	22	)	)	PUNCT
aiua-13277	73	23	,	,	PUNCT
aiua-13277	73	24	and	and	CCONJ
aiua-13277	73	25	3	3	NUM
aiua-13277	73	26	-	-	NUM
aiua-13277	73	27	methylxanthine	methylxanthine	ADJ
aiua-13277	73	28	(	(	PUNCT
aiua-13277	73	29	3	3	NUM
aiua-13277	73	30	-	-	SYM
aiua-13277	73	31	mx	mx	NOUN
aiua-13277	73	32	)	)	PUNCT
aiua-13277	73	33	significantly	significantly	ADV
aiua-13277	73	34	inhibited	inhibit	VERB
aiua-13277	73	35	xanthine	xanthine	NOUN
aiua-13277	73	36	crystallization	crystallization	NOUN
aiua-13277	73	37	in	in	ADP
aiua-13277	73	38	vitro	vitro	ADJ
aiua-13277	73	39	in	in	ADP
aiua-13277	73	40	a	a	DET
aiua-13277	73	41	concentration	concentration	NOUN
aiua-13277	73	42	dependent	dependent	ADJ
aiua-13277	73	43	manner	manner	NOUN
aiua-13277	73	44	(	(	PUNCT
aiua-13277	73	45	36	36	NUM
aiua-13277	73	46	)	)	PUNCT
aiua-13277	73	47	.	.	PUNCT
aiua-13277	74	1	archivio	archivio	NOUN
aiua-13277	74	2	italiano	italiano	PROPN
aiua-13277	74	3	di	di	X
aiua-13277	74	4	urologia	urologia	PROPN
aiua-13277	74	5	e	e	PROPN
aiua-13277	74	6	andrologia	andrologia	NOUN
aiua-13277	74	7	2024	2024	NUM
aiua-13277	74	8	;	;	PUNCT
aiua-13277	74	9	96(4):13277	96(4):13277	NUM
aiua-13277	74	10	3	3	NUM
aiua-13277	74	11	theobromine	theobromine	ADJ
aiua-13277	74	12	and	and	CCONJ
aiua-13277	74	13	uric	uric	ADJ
aiua-13277	74	14	acid	acid	NOUN
aiua-13277	74	15	stones	stone	NOUN
aiua-13277	74	16	two	two	NUM
aiua-13277	74	17	of	of	ADP
aiua-13277	74	18	these	these	DET
aiua-13277	74	19	molecules	molecule	NOUN
aiua-13277	74	20	are	be	AUX
aiua-13277	74	21	major	major	ADJ
aiua-13277	74	22	metabolites	metabolite	NOUN
aiua-13277	74	23	of	of	ADP
aiua-13277	74	24	theobromine	theobromine	NOUN
aiua-13277	74	25	whereas	whereas	SCONJ
aiua-13277	74	26	the	the	DET
aiua-13277	74	27	third	third	NOUN
aiua-13277	74	28	is	be	AUX
aiua-13277	74	29	a	a	DET
aiua-13277	74	30	metabolite	metabolite	NOUN
aiua-13277	74	31	of	of	ADP
aiua-13277	74	32	caffeine	caffeine	NOUN
aiua-13277	74	33	.	.	PUNCT
aiua-13277	75	1	in	in	ADP
aiua-13277	75	2	fact	fact	NOUN
aiua-13277	75	3	,	,	PUNCT
aiua-13277	75	4	after	after	ADP
aiua-13277	75	5	theobromine	theobromine	ADJ
aiua-13277	75	6	ingestion	ingestion	NOUN
aiua-13277	75	7	,	,	PUNCT
aiua-13277	75	8	20	20	NUM
aiua-13277	75	9	%	%	NOUN
aiua-13277	75	10	is	be	AUX
aiua-13277	75	11	excreted	excrete	VERB
aiua-13277	75	12	as	as	ADP
aiua-13277	75	13	theobromine	theobromine	NOUN
aiua-13277	75	14	,	,	PUNCT
aiua-13277	75	15	21.5	21.5	NUM
aiua-13277	75	16	%	%	NOUN
aiua-13277	75	17	as	as	ADP
aiua-13277	75	18	3	3	NUM
aiua-13277	75	19	-	-	SYM
aiua-13277	75	20	mx	mx	NOUN
aiua-13277	75	21	,	,	PUNCT
aiua-13277	75	22	and	and	CCONJ
aiua-13277	75	23	36	36	NUM
aiua-13277	75	24	%	%	NOUN
aiua-13277	75	25	as	as	ADP
aiua-13277	75	26	7	7	NUM
aiua-13277	75	27	-	-	SYM
aiua-13277	75	28	mx	mx	NOUN
aiua-13277	75	29	and	and	CCONJ
aiua-13277	75	30	after	after	ADP
aiua-13277	75	31	consumption	consumption	NOUN
aiua-13277	75	32	of	of	ADP
aiua-13277	75	33	caffeine	caffeine	NOUN
aiua-13277	75	34	,	,	PUNCT
aiua-13277	75	35	19	19	NUM
aiua-13277	75	36	%	%	NOUN
aiua-13277	75	37	of	of	ADP
aiua-13277	75	38	it	it	PRON
aiua-13277	75	39	is	be	AUX
aiua-13277	75	40	excreted	excrete	VERB
aiua-13277	75	41	as	as	ADP
aiua-13277	75	42	1	1	NUM
aiua-13277	75	43	-	-	SYM
aiua-13277	75	44	mx	mx	PROPN
aiua-13277	75	45	.	.	PROPN
aiua-13277	75	46	hypoxanthine	hypoxanthine	PROPN
aiua-13277	75	47	(	(	PUNCT
aiua-13277	75	48	hx	hx	PROPN
aiua-13277	75	49	)	)	PUNCT
aiua-13277	75	50	,	,	PUNCT
aiua-13277	75	51	theophylline	theophylline	NOUN
aiua-13277	75	52	(	(	PUNCT
aiua-13277	75	53	tp	tp	NOUN
aiua-13277	75	54	)	)	PUNCT
aiua-13277	75	55	,	,	PUNCT
aiua-13277	75	56	paraxanthine	paraxanthine	NOUN
aiua-13277	75	57	(	(	PUNCT
aiua-13277	75	58	px	px	PROPN
aiua-13277	75	59	)	)	PUNCT
aiua-13277	75	60	,	,	PUNCT
aiua-13277	75	61	theobromine	theobromine	NOUN
aiua-13277	75	62	(	(	PUNCT
aiua-13277	75	63	tb	tb	NOUN
aiua-13277	75	64	)	)	PUNCT
aiua-13277	75	65	,	,	PUNCT
aiua-13277	75	66	caffeine	caffeine	NOUN
aiua-13277	75	67	(	(	PUNCT
aiua-13277	75	68	cf	cf	NOUN
aiua-13277	75	69	)	)	PUNCT
aiua-13277	75	70	,	,	PUNCT
aiua-13277	75	71	1	1	NUM
aiua-13277	75	72	-	-	PUNCT
aiua-13277	75	73	methyluric	methyluric	ADJ
aiua-13277	75	74	acid	acid	NOUN
aiua-13277	75	75	(	(	PUNCT
aiua-13277	75	76	1	1	NUM
aiua-13277	75	77	-	-	NUM
aiua-13277	75	78	mu	mu	NOUN
aiua-13277	75	79	)	)	PUNCT
aiua-13277	75	80	,	,	PUNCT
aiua-13277	75	81	and	and	CCONJ
aiua-13277	75	82	1,3	1,3	NUM
aiua-13277	75	83	-	-	PUNCT
aiua-13277	75	84	dimethyluric	dimethyluric	ADJ
aiua-13277	75	85	acid	acid	NOUN
aiua-13277	75	86	(	(	PUNCT
aiua-13277	75	87	1,3	1,3	NUM
aiua-13277	75	88	-	-	PUNCT
aiua-13277	75	89	dmua	dmua	NOUN
aiua-13277	75	90	)	)	PUNCT
aiua-13277	75	91	showed	show	VERB
aiua-13277	75	92	no	no	DET
aiua-13277	75	93	significant	significant	ADJ
aiua-13277	75	94	inhibitory	inhibitory	ADJ
aiua-13277	75	95	effect	effect	NOUN
aiua-13277	75	96	on	on	ADP
aiua-13277	75	97	xanthine	xanthine	NOUN
aiua-13277	75	98	crystallization	crystallization	NOUN
aiua-13277	75	99	because	because	SCONJ
aiua-13277	75	100	only	only	ADV
aiua-13277	75	101	methyl	methyl	NOUN
aiua-13277	75	102	derivatives	derivative	NOUN
aiua-13277	75	103	of	of	ADP
aiua-13277	75	104	xanthine	xanthine	NOUN
aiua-13277	75	105	can	can	AUX
aiua-13277	75	106	be	be	AUX
aiua-13277	75	107	incorporated	incorporate	VERB
aiua-13277	75	108	into	into	ADP
aiua-13277	75	109	the	the	DET
aiua-13277	75	110	xanthine	xanthine	NOUN
aiua-13277	75	111	crystal	crystal	PROPN
aiua-13277	75	112	lattice	lattice	PROPN
aiua-13277	75	113	modifying	modify	VERB
aiua-13277	75	114	its	its	PRON
aiua-13277	75	115	structure	structure	NOUN
aiua-13277	75	116	and	and	CCONJ
aiua-13277	75	117	slowing	slow	VERB
aiua-13277	75	118	crystal	crystal	NOUN
aiua-13277	75	119	growth	growth	NOUN
aiua-13277	75	120	(	(	PUNCT
aiua-13277	75	121	by	by	ADP
aiua-13277	75	122	increasing	increase	VERB
aiua-13277	75	123	gibbs	gibbs	PROPN
aiua-13277	75	124	free	free	ADJ
aiua-13277	75	125	energy	energy	NOUN
aiua-13277	75	126	)	)	PUNCT
aiua-13277	75	127	.	.	PUNCT
aiua-13277	76	1	however	however	ADV
aiua-13277	76	2	,	,	PUNCT
aiua-13277	76	3	even	even	ADV
aiua-13277	76	4	if	if	SCONJ
aiua-13277	76	5	theobromine	theobromine	NOUN
aiua-13277	76	6	did	do	AUX
aiua-13277	76	7	not	not	PART
aiua-13277	76	8	inhibit	inhibit	VERB
aiua-13277	76	9	xanthine	xanthine	NOUN
aiua-13277	76	10	crystallization	crystallization	NOUN
aiua-13277	76	11	by	by	ADP
aiua-13277	76	12	itself	itself	PRON
aiua-13277	76	13	,	,	PUNCT
aiua-13277	76	14	it	it	PRON
aiua-13277	76	15	could	could	AUX
aiua-13277	76	16	be	be	AUX
aiua-13277	76	17	used	use	VERB
aiua-13277	76	18	for	for	ADP
aiua-13277	76	19	prevention	prevention	NOUN
aiua-13277	76	20	of	of	ADP
aiua-13277	76	21	xanthine	xanthine	NOUN
aiua-13277	76	22	stones	stone	NOUN
aiua-13277	76	23	by	by	ADP
aiua-13277	76	24	the	the	DET
aiua-13277	76	25	effects	effect	NOUN
aiua-13277	76	26	of	of	ADP
aiua-13277	76	27	its	its	PRON
aiua-13277	76	28	metabolites	metabolite	NOUN
aiua-13277	76	29	.	.	PUNCT
aiua-13277	77	1	theobromine	theobromine	NOUN
aiua-13277	77	2	and	and	CCONJ
aiua-13277	77	3	gout	gout	NOUN
aiua-13277	77	4	gout	gout	NOUN
aiua-13277	77	5	is	be	AUX
aiua-13277	77	6	a	a	DET
aiua-13277	77	7	rheumatic	rheumatic	ADJ
aiua-13277	77	8	disease	disease	NOUN
aiua-13277	77	9	presenting	present	VERB
aiua-13277	77	10	with	with	ADP
aiua-13277	77	11	pain	pain	NOUN
aiua-13277	77	12	,	,	PUNCT
aiua-13277	77	13	swelling	swelling	NOUN
aiua-13277	77	14	,	,	PUNCT
aiua-13277	77	15	and	and	CCONJ
aiua-13277	77	16	redness	redness	NOUN
aiua-13277	77	17	in	in	ADP
aiua-13277	77	18	the	the	DET
aiua-13277	77	19	peripheral	peripheral	ADJ
aiua-13277	77	20	joints	joint	NOUN
aiua-13277	77	21	,	,	PUNCT
aiua-13277	77	22	especially	especially	ADV
aiua-13277	77	23	in	in	ADP
aiua-13277	77	24	the	the	DET
aiua-13277	77	25	metatarsophalangeal	metatarsophalangeal	ADJ
aiua-13277	77	26	joint	joint	NOUN
aiua-13277	77	27	in	in	ADP
aiua-13277	77	28	the	the	DET
aiua-13277	77	29	big	big	ADJ
aiua-13277	77	30	toe	toe	NOUN
aiua-13277	77	31	and	and	CCONJ
aiua-13277	77	32	other	other	ADJ
aiua-13277	77	33	joints	joint	NOUN
aiua-13277	77	34	in	in	ADP
aiua-13277	77	35	the	the	DET
aiua-13277	77	36	feet	foot	NOUN
aiua-13277	77	37	and	and	CCONJ
aiua-13277	77	38	hands	hand	NOUN
aiua-13277	77	39	(	(	PUNCT
aiua-13277	77	40	37	37	NUM
aiua-13277	77	41	)	)	PUNCT
aiua-13277	77	42	.	.	PUNCT
aiua-13277	78	1	the	the	DET
aiua-13277	78	2	disease	disease	NOUN
aiua-13277	78	3	is	be	AUX
aiua-13277	78	4	due	due	ADJ
aiua-13277	78	5	to	to	ADP
aiua-13277	78	6	accumulation	accumulation	NOUN
aiua-13277	78	7	of	of	ADP
aiua-13277	78	8	monosodium	monosodium	NOUN
aiua-13277	78	9	urate	urate	NOUN
aiua-13277	78	10	(	(	PUNCT
aiua-13277	78	11	nau	nau	PROPN
aiua-13277	78	12	)	)	PUNCT
aiua-13277	78	13	needle	needle	NOUN
aiua-13277	78	14	-	-	PUNCT
aiua-13277	78	15	shaped	shape	VERB
aiua-13277	78	16	crystals	crystal	NOUN
aiua-13277	78	17	in	in	ADP
aiua-13277	78	18	the	the	DET
aiua-13277	78	19	affected	affected	ADJ
aiua-13277	78	20	joints	joint	NOUN
aiua-13277	78	21	.	.	PUNCT
aiua-13277	79	1	synovial	synovial	ADJ
aiua-13277	79	2	fluid	fluid	NOUN
aiua-13277	79	3	is	be	AUX
aiua-13277	79	4	an	an	DET
aiua-13277	79	5	ultrafiltrate	ultrafiltrate	ADJ
aiua-13277	79	6	from	from	ADP
aiua-13277	79	7	plasma	plasma	NOUN
aiua-13277	79	8	with	with	ADP
aiua-13277	79	9	a	a	DET
aiua-13277	79	10	ph	ph	NOUN
aiua-13277	79	11	of	of	ADP
aiua-13277	79	12	7.4	7.4	NUM
aiua-13277	79	13	and	and	CCONJ
aiua-13277	79	14	a	a	DET
aiua-13277	79	15	sodium	sodium	NOUN
aiua-13277	79	16	level	level	NOUN
aiua-13277	79	17	of	of	ADP
aiua-13277	79	18	about	about	ADV
aiua-13277	79	19	150	150	NUM
aiua-13277	79	20	mmol	mmol	NOUN
aiua-13277	79	21	/	/	SYM
aiua-13277	79	22	l.	l.	NOUN
aiua-13277	79	23	at	at	ADP
aiua-13277	79	24	a	a	DET
aiua-13277	79	25	ph	ph	NOUN
aiua-13277	79	26	of	of	ADP
aiua-13277	79	27	7.4	7.4	NUM
aiua-13277	79	28	most	most	ADV
aiua-13277	79	29	uric	uric	ADJ
aiua-13277	79	30	acid	acid	NOUN
aiua-13277	79	31	is	be	AUX
aiua-13277	79	32	present	present	ADJ
aiua-13277	79	33	as	as	ADP
aiua-13277	79	34	univalent	univalent	ADJ
aiua-13277	79	35	anionic	anionic	ADJ
aiua-13277	79	36	urate	urate	NOUN
aiua-13277	79	37	,	,	PUNCT
aiua-13277	79	38	whereas	whereas	SCONJ
aiua-13277	79	39	at	at	ADP
aiua-13277	79	40	serum	serum	NOUN
aiua-13277	79	41	urate	urate	NOUN
aiua-13277	79	42	level	level	NOUN
aiua-13277	79	43	below	below	ADP
aiua-13277	79	44	6	6	NUM
aiua-13277	79	45	mg	mg	PROPN
aiua-13277	79	46	/	/	SYM
aiua-13277	79	47	dl	dl	PROPN
aiua-13277	79	48	sodium	sodium	NOUN
aiua-13277	79	49	urate	urate	NOUN
aiua-13277	79	50	crystals	crystal	NOUN
aiua-13277	79	51	do	do	AUX
aiua-13277	79	52	not	not	PART
aiua-13277	79	53	form	form	VERB
aiua-13277	79	54	because	because	SCONJ
aiua-13277	79	55	sodium	sodium	NOUN
aiua-13277	79	56	urate	urate	NOUN
aiua-13277	79	57	solubility	solubility	NOUN
aiua-13277	79	58	threshold	threshold	NOUN
aiua-13277	79	59	is	be	AUX
aiua-13277	79	60	6.6	6.6	NUM
aiua-13277	79	61	mg	mg	PROPN
aiua-13277	79	62	/	/	SYM
aiua-13277	79	63	dl	dl	PROPN
aiua-13277	79	64	.	.	PROPN
aiua-13277	79	65	when	when	SCONJ
aiua-13277	79	66	urate	urate	NOUN
aiua-13277	79	67	levels	level	NOUN
aiua-13277	79	68	are	be	AUX
aiua-13277	79	69	over	over	ADP
aiua-13277	79	70	the	the	DET
aiua-13277	79	71	solubility	solubility	NOUN
aiua-13277	79	72	limit	limit	NOUN
aiua-13277	79	73	of	of	ADP
aiua-13277	79	74	6.6	6.6	NUM
aiua-13277	79	75	mg	mg	PROPN
aiua-13277	79	76	/	/	SYM
aiua-13277	79	77	dl	dl	PROPN
aiua-13277	79	78	sodium	sodium	NOUN
aiua-13277	79	79	urate	urate	NOUN
aiua-13277	79	80	crystals	crystal	NOUN
aiua-13277	79	81	start	start	VERB
aiua-13277	79	82	to	to	PART
aiua-13277	79	83	form	form	VERB
aiua-13277	79	84	.	.	PUNCT
aiua-13277	80	1	furthermore	furthermore	ADV
aiua-13277	80	2	,	,	PUNCT
aiua-13277	80	3	solubility	solubility	NOUN
aiua-13277	80	4	of	of	ADP
aiua-13277	80	5	sodium	sodium	NOUN
aiua-13277	80	6	urate	urate	NOUN
aiua-13277	80	7	is	be	AUX
aiua-13277	80	8	related	relate	VERB
aiua-13277	80	9	to	to	ADP
aiua-13277	80	10	temperature	temperature	NOUN
aiua-13277	80	11	and	and	CCONJ
aiua-13277	80	12	tends	tend	VERB
aiua-13277	80	13	to	to	PART
aiua-13277	80	14	decrease	decrease	VERB
aiua-13277	80	15	at	at	ADP
aiua-13277	80	16	temperature	temperature	NOUN
aiua-13277	80	17	lower	low	ADJ
aiua-13277	80	18	than	than	ADP
aiua-13277	80	19	37	37	NUM
aiua-13277	80	20	°	°	NOUN
aiua-13277	80	21	c	c	NOUN
aiua-13277	80	22	,	,	PUNCT
aiua-13277	80	23	being	be	AUX
aiua-13277	80	24	only	only	ADV
aiua-13277	80	25	3.7	3.7	NUM
aiua-13277	80	26	mg	mg	PROPN
aiua-13277	80	27	/	/	SYM
aiua-13277	80	28	dl	dl	PROPN
aiua-13277	80	29	at	at	ADP
aiua-13277	80	30	26	26	NUM
aiua-13277	80	31	°	°	NOUN
aiua-13277	80	32	c	c	NOUN
aiua-13277	80	33	.	.	PUNCT
aiua-13277	81	1	this	this	PRON
aiua-13277	81	2	explains	explain	VERB
aiua-13277	81	3	why	why	SCONJ
aiua-13277	81	4	crystal	crystal	NOUN
aiua-13277	81	5	formation	formation	NOUN
aiua-13277	81	6	is	be	AUX
aiua-13277	81	7	more	more	ADV
aiua-13277	81	8	common	common	ADJ
aiua-13277	81	9	in	in	ADP
aiua-13277	81	10	the	the	DET
aiua-13277	81	11	joints	joint	NOUN
aiua-13277	81	12	of	of	ADP
aiua-13277	81	13	the	the	DET
aiua-13277	81	14	hands	hand	NOUN
aiua-13277	81	15	and	and	CCONJ
aiua-13277	81	16	feet	foot	NOUN
aiua-13277	81	17	where	where	SCONJ
aiua-13277	81	18	temperature	temperature	NOUN
aiua-13277	81	19	tends	tend	VERB
aiua-13277	81	20	to	to	PART
aiua-13277	81	21	be	be	AUX
aiua-13277	81	22	lower	low	ADJ
aiua-13277	81	23	(	(	PUNCT
aiua-13277	81	24	38	38	NUM
aiua-13277	81	25	)	)	PUNCT
aiua-13277	81	26	.	.	PUNCT
aiua-13277	82	1	the	the	DET
aiua-13277	82	2	pathophysiology	pathophysiology	NOUN
aiua-13277	82	3	of	of	ADP
aiua-13277	82	4	crystal	crystal	NOUN
aiua-13277	82	5	formation	formation	NOUN
aiua-13277	82	6	in	in	ADP
aiua-13277	82	7	synovial	synovial	ADJ
aiua-13277	82	8	fluids	fluid	NOUN
aiua-13277	82	9	is	be	AUX
aiua-13277	82	10	peculiar	peculiar	ADJ
aiua-13277	82	11	because	because	SCONJ
aiua-13277	82	12	the	the	DET
aiua-13277	82	13	circulation	circulation	NOUN
aiua-13277	82	14	of	of	ADP
aiua-13277	82	15	fluids	fluid	NOUN
aiua-13277	82	16	in	in	ADP
aiua-13277	82	17	the	the	DET
aiua-13277	82	18	cavities	cavity	NOUN
aiua-13277	82	19	of	of	ADP
aiua-13277	82	20	synovial	synovial	ADJ
aiua-13277	82	21	joints	joint	NOUN
aiua-13277	82	22	is	be	AUX
aiua-13277	82	23	quite	quite	ADV
aiua-13277	82	24	limited	limited	ADJ
aiua-13277	82	25	with	with	ADP
aiua-13277	82	26	a	a	DET
aiua-13277	82	27	much	much	ADV
aiua-13277	82	28	slower	slow	ADJ
aiua-13277	82	29	renewal	renewal	NOUN
aiua-13277	82	30	of	of	ADP
aiua-13277	82	31	fluids	fluid	NOUN
aiua-13277	82	32	compared	compare	VERB
aiua-13277	82	33	to	to	ADP
aiua-13277	82	34	urinary	urinary	ADJ
aiua-13277	82	35	tract	tract	NOUN
aiua-13277	82	36	where	where	SCONJ
aiua-13277	82	37	the	the	DET
aiua-13277	82	38	flow	flow	NOUN
aiua-13277	82	39	of	of	ADP
aiua-13277	82	40	urine	urine	NOUN
aiua-13277	82	41	is	be	AUX
aiua-13277	82	42	continuous	continuous	ADJ
aiua-13277	82	43	and	and	CCONJ
aiua-13277	82	44	relatively	relatively	ADV
aiua-13277	82	45	fast	fast	ADV
aiua-13277	82	46	.	.	PUNCT
aiua-13277	83	1	consequently	consequently	ADV
aiua-13277	83	2	,	,	PUNCT
aiua-13277	83	3	inhibitors	inhibitor	NOUN
aiua-13277	83	4	that	that	PRON
aiua-13277	83	5	can	can	AUX
aiua-13277	83	6	prevent	prevent	VERB
aiua-13277	83	7	crystal	crystal	NOUN
aiua-13277	83	8	formation	formation	NOUN
aiua-13277	83	9	for	for	ADP
aiua-13277	83	10	a	a	DET
aiua-13277	83	11	period	period	NOUN
aiua-13277	83	12	up	up	ADP
aiua-13277	83	13	to	to	PART
aiua-13277	83	14	30	30	NUM
aiua-13277	83	15	-	-	SYM
aiua-13277	83	16	40	40	NUM
aiua-13277	83	17	minutes	minute	NOUN
aiua-13277	83	18	can	can	AUX
aiua-13277	83	19	be	be	AUX
aiua-13277	83	20	useful	useful	ADJ
aiua-13277	83	21	in	in	ADP
aiua-13277	83	22	continuous	continuous	ADJ
aiua-13277	83	23	flow	flow	NOUN
aiua-13277	83	24	of	of	ADP
aiua-13277	83	25	urine	urine	NOUN
aiua-13277	83	26	,	,	PUNCT
aiua-13277	83	27	but	but	CCONJ
aiua-13277	83	28	they	they	PRON
aiua-13277	83	29	are	be	AUX
aiua-13277	83	30	ineffective	ineffective	ADJ
aiua-13277	83	31	in	in	ADP
aiua-13277	83	32	absence	absence	NOUN
aiua-13277	83	33	of	of	ADP
aiua-13277	83	34	renewal	renewal	NOUN
aiua-13277	83	35	of	of	ADP
aiua-13277	83	36	fluid	fluid	NOUN
aiua-13277	83	37	as	as	ADP
aiua-13277	83	38	in	in	ADP
aiua-13277	83	39	the	the	DET
aiua-13277	83	40	joint	joint	ADJ
aiua-13277	83	41	cavities	cavity	NOUN
aiua-13277	83	42	.	.	PUNCT
aiua-13277	84	1	treatment	treatment	NOUN
aiua-13277	84	2	of	of	ADP
aiua-13277	84	3	gout	gout	NOUN
aiua-13277	84	4	is	be	AUX
aiua-13277	84	5	based	base	VERB
aiua-13277	84	6	on	on	ADP
aiua-13277	84	7	anti	anti	ADJ
aiua-13277	84	8	-	-	ADJ
aiua-13277	84	9	inflammatory	inflammatory	ADJ
aiua-13277	84	10	drugs	drug	NOUN
aiua-13277	84	11	and	and	CCONJ
aiua-13277	84	12	the	the	DET
aiua-13277	84	13	reduction	reduction	NOUN
aiua-13277	84	14	of	of	ADP
aiua-13277	84	15	serum	serum	NOUN
aiua-13277	84	16	urate	urate	NOUN
aiua-13277	84	17	levels	level	NOUN
aiua-13277	84	18	by	by	ADP
aiua-13277	84	19	a	a	DET
aiua-13277	84	20	low	low	ADJ
aiua-13277	84	21	purine	purine	NOUN
aiua-13277	84	22	diet	diet	NOUN
aiua-13277	84	23	,	,	PUNCT
aiua-13277	84	24	or	or	CCONJ
aiua-13277	84	25	drugs	drug	NOUN
aiua-13277	84	26	decreasing	decrease	VERB
aiua-13277	84	27	the	the	DET
aiua-13277	84	28	production	production	NOUN
aiua-13277	84	29	of	of	ADP
aiua-13277	84	30	uric	uric	ADJ
aiua-13277	84	31	acid	acid	NOUN
aiua-13277	84	32	,	,	PUNCT
aiua-13277	84	33	as	as	SCONJ
aiua-13277	84	34	allopurinol	allopurinol	NOUN
aiua-13277	84	35	and	and	CCONJ
aiua-13277	84	36	febuxostat	febuxostat	NOUN
aiua-13277	84	37	or	or	CCONJ
aiua-13277	84	38	drugs	drug	NOUN
aiua-13277	84	39	increasing	increase	VERB
aiua-13277	84	40	the	the	DET
aiua-13277	84	41	urinary	urinary	ADJ
aiua-13277	84	42	excretion	excretion	NOUN
aiua-13277	84	43	of	of	ADP
aiua-13277	84	44	uric	uric	ADJ
aiua-13277	84	45	acid	acid	NOUN
aiua-13277	84	46	,	,	PUNCT
aiua-13277	84	47	such	such	ADJ
aiua-13277	84	48	as	as	ADP
aiua-13277	84	49	probenecid	probenecid	PROPN
aiua-13277	84	50	.	.	PUNCT
aiua-13277	85	1	an	an	DET
aiua-13277	85	2	alternative	alternative	ADJ
aiua-13277	85	3	approach	approach	NOUN
aiua-13277	85	4	could	could	AUX
aiua-13277	85	5	be	be	AUX
aiua-13277	85	6	increasing	increase	VERB
aiua-13277	85	7	urate	urate	NOUN
aiua-13277	85	8	solubility	solubility	NOUN
aiua-13277	85	9	or	or	CCONJ
aiua-13277	85	10	inhibit	inhibit	VERB
aiua-13277	85	11	sodium	sodium	NOUN
aiua-13277	85	12	urate	urate	NOUN
aiua-13277	85	13	crystallization	crystallization	NOUN
aiua-13277	85	14	.	.	PUNCT
aiua-13277	86	1	some	some	PRON
aiua-13277	86	2	in	in	ADP
aiua-13277	86	3	vitro	vitro	X
aiua-13277	86	4	studies	study	NOUN
aiua-13277	86	5	demonstrated	demonstrate	VERB
aiua-13277	86	6	that	that	SCONJ
aiua-13277	86	7	the	the	DET
aiua-13277	86	8	combination	combination	NOUN
aiua-13277	86	9	of	of	ADP
aiua-13277	86	10	arginine	arginine	NOUN
aiua-13277	86	11	-	-	PUNCT
aiua-13277	86	12	rich	rich	ADJ
aiua-13277	86	13	peptide	peptide	NOUN
aiua-13277	86	14	and	and	CCONJ
aiua-13277	86	15	copper	copper	NOUN
aiua-13277	86	16	ions	ion	NOUN
aiua-13277	86	17	was	be	AUX
aiua-13277	86	18	able	able	ADJ
aiua-13277	86	19	to	to	PART
aiua-13277	86	20	delay	delay	VERB
aiua-13277	86	21	the	the	DET
aiua-13277	86	22	crystallization	crystallization	NOUN
aiua-13277	86	23	of	of	ADP
aiua-13277	86	24	sodium	sodium	NOUN
aiua-13277	86	25	urate	urate	NOUN
aiua-13277	86	26	(	(	PUNCT
aiua-13277	86	27	39	39	NUM
aiua-13277	86	28	,	,	PUNCT
aiua-13277	86	29	40	40	NUM
aiua-13277	86	30	)	)	PUNCT
aiua-13277	86	31	.	.	PUNCT
aiua-13277	87	1	similarly	similarly	ADV
aiua-13277	87	2	,	,	PUNCT
aiua-13277	87	3	the	the	DET
aiua-13277	87	4	addition	addition	NOUN
aiua-13277	87	5	of	of	ADP
aiua-13277	87	6	trimethoprim	trimethoprim	NOUN
aiua-13277	87	7	to	to	PART
aiua-13277	87	8	urate	urate	VERB
aiua-13277	87	9	solutions	solution	NOUN
aiua-13277	87	10	delayed	delay	VERB
aiua-13277	87	11	sodium	sodium	NOUN
aiua-13277	87	12	urate	urate	NOUN
aiua-13277	87	13	crystallization	crystallization	NOUN
aiua-13277	87	14	because	because	SCONJ
aiua-13277	87	15	trimethoprim	trimethoprim	PROPN
aiua-13277	87	16	acted	act	VERB
aiua-13277	87	17	as	as	ADP
aiua-13277	87	18	competing	compete	VERB
aiua-13277	87	19	binding	bind	VERB
aiua-13277	87	20	agent	agent	NOUN
aiua-13277	87	21	forming	form	VERB
aiua-13277	87	22	a	a	DET
aiua-13277	87	23	more	more	ADV
aiua-13277	87	24	soluble	soluble	ADJ
aiua-13277	87	25	co	co	NOUN
aiua-13277	87	26	-	-	NOUN
aiua-13277	87	27	crystal	crystal	NOUN
aiua-13277	87	28	with	with	ADP
aiua-13277	87	29	sodium	sodium	NOUN
aiua-13277	87	30	urate	urate	NOUN
aiua-13277	87	31	(	(	PUNCT
aiua-13277	87	32	41	41	NUM
aiua-13277	87	33	)	)	PUNCT
aiua-13277	87	34	.	.	PUNCT
aiua-13277	88	1	theobromine	theobromine	NOUN
aiua-13277	88	2	can	can	AUX
aiua-13277	88	3	form	form	VERB
aiua-13277	88	4	aggregates	aggregate	NOUN
aiua-13277	88	5	with	with	ADP
aiua-13277	88	6	uric	uric	ADJ
aiua-13277	88	7	acid	acid	NOUN
aiua-13277	88	8	through	through	ADP
aiua-13277	88	9	hydrogen	hydrogen	NOUN
aiua-13277	88	10	bonds	bond	NOUN
aiua-13277	88	11	and	and	CCONJ
aiua-13277	88	12	aromatic	aromatic	ADJ
aiua-13277	88	13	stacking	stacking	NOUN
aiua-13277	88	14	interactions	interaction	NOUN
aiua-13277	88	15	(	(	PUNCT
aiua-13277	88	16	-stacking	-stacking	ADJ
aiua-13277	88	17	bonds	bond	NOUN
aiua-13277	88	18	)	)	PUNCT
aiua-13277	88	19	increasing	increase	VERB
aiua-13277	88	20	urinary	urinary	ADJ
aiua-13277	88	21	solubility	solubility	NOUN
aiua-13277	88	22	of	of	ADP
aiua-13277	88	23	uric	uric	ADJ
aiua-13277	88	24	acid	acid	NOUN
aiua-13277	88	25	(	(	PUNCT
aiua-13277	88	26	42	42	NUM
aiua-13277	88	27	)	)	PUNCT
aiua-13277	88	28	.	.	PUNCT
aiua-13277	89	1	similarly	similarly	ADV
aiua-13277	89	2	,	,	PUNCT
aiua-13277	89	3	the	the	DET
aiua-13277	89	4	solubility	solubility	NOUN
aiua-13277	89	5	of	of	ADP
aiua-13277	89	6	uric	uric	ADJ
aiua-13277	89	7	acid	acid	NOUN
aiua-13277	89	8	increased	increase	VERB
aiua-13277	89	9	in	in	ADP
aiua-13277	89	10	the	the	DET
aiua-13277	89	11	presence	presence	NOUN
aiua-13277	89	12	of	of	ADP
aiua-13277	89	13	vitamin	vitamin	NOUN
aiua-13277	89	14	c	c	NOUN
aiua-13277	89	15	(	(	PUNCT
aiua-13277	89	16	43	43	NUM
aiua-13277	89	17	)	)	PUNCT
aiua-13277	89	18	.	.	PUNCT
aiua-13277	90	1	furthermore	furthermore	ADV
aiua-13277	90	2	,	,	PUNCT
aiua-13277	90	3	theobromine	theobromine	NOUN
aiua-13277	90	4	is	be	AUX
aiua-13277	90	5	also	also	ADV
aiua-13277	90	6	able	able	ADJ
aiua-13277	90	7	to	to	PART
aiua-13277	90	8	interact	interact	VERB
aiua-13277	90	9	with	with	ADP
aiua-13277	90	10	uric	uric	ADJ
aiua-13277	90	11	acid	acid	NOUN
aiua-13277	90	12	crystals	crystal	NOUN
aiua-13277	90	13	changing	change	VERB
aiua-13277	90	14	their	their	PRON
aiua-13277	90	15	morphology	morphology	NOUN
aiua-13277	90	16	.	.	PUNCT
aiua-13277	91	1	epidemiological	epidemiological	ADJ
aiua-13277	91	2	studies	study	NOUN
aiua-13277	91	3	demonstrated	demonstrate	VERB
aiua-13277	91	4	that	that	SCONJ
aiua-13277	91	5	coffee	coffee	NOUN
aiua-13277	91	6	and	and	CCONJ
aiua-13277	91	7	chocolate	chocolate	NOUN
aiua-13277	91	8	consumption	consumption	NOUN
aiua-13277	91	9	decreased	decrease	VERB
aiua-13277	91	10	the	the	DET
aiua-13277	91	11	risk	risk	NOUN
aiua-13277	91	12	of	of	ADP
aiua-13277	91	13	gout	gout	NOUN
aiua-13277	91	14	(	(	PUNCT
aiua-13277	91	15	44	44	NUM
aiua-13277	91	16	,	,	PUNCT
aiua-13277	91	17	45	45	NUM
aiua-13277	91	18	)	)	PUNCT
aiua-13277	91	19	.	.	PUNCT
aiua-13277	92	1	an	an	DET
aiua-13277	92	2	in	in	ADP
aiua-13277	92	3	vitro	vitro	X
aiua-13277	92	4	study	study	NOUN
aiua-13277	92	5	suggested	suggest	VERB
aiua-13277	92	6	that	that	SCONJ
aiua-13277	92	7	7	7	NUM
aiua-13277	92	8	-	-	NUM
aiua-13277	92	9	methylxanthine	methylxanthine	NOUN
aiua-13277	92	10	,	,	PUNCT
aiua-13277	92	11	a	a	DET
aiua-13277	92	12	metabolite	metabolite	NOUN
aiua-13277	92	13	of	of	ADP
aiua-13277	92	14	theobromine	theobromine	NOUN
aiua-13277	92	15	,	,	PUNCT
aiua-13277	92	16	has	have	VERB
aiua-13277	92	17	the	the	DET
aiua-13277	92	18	potential	potential	NOUN
aiua-13277	92	19	to	to	PART
aiua-13277	92	20	be	be	AUX
aiua-13277	92	21	used	use	VERB
aiua-13277	92	22	for	for	ADP
aiua-13277	92	23	the	the	DET
aiua-13277	92	24	prevention	prevention	NOUN
aiua-13277	92	25	of	of	ADP
aiua-13277	92	26	gout	gout	NOUN
aiua-13277	92	27	(	(	PUNCT
aiua-13277	92	28	46	46	NUM
aiua-13277	92	29	)	)	PUNCT
aiua-13277	92	30	.	.	PUNCT
aiua-13277	93	1	the	the	DET
aiua-13277	93	2	same	same	ADJ
aiua-13277	93	3	study	study	NOUN
aiua-13277	93	4	found	find	VERB
aiua-13277	93	5	that	that	SCONJ
aiua-13277	93	6	3	3	NUM
aiua-13277	93	7	-	-	NUM
aiua-13277	93	8	methylxanthine	methylxanthine	NOUN
aiua-13277	93	9	also	also	ADV
aiua-13277	93	10	prevented	prevent	VERB
aiua-13277	93	11	crystallization	crystallization	NOUN
aiua-13277	93	12	,	,	PUNCT
aiua-13277	93	13	although	although	SCONJ
aiua-13277	93	14	this	this	PRON
aiua-13277	93	15	happens	happen	VERB
aiua-13277	93	16	at	at	ADP
aiua-13277	93	17	a	a	DET
aiua-13277	93	18	four	four	NUM
aiua-13277	93	19	-	-	ADJ
aiua-13277	93	20	fold	fold	ADJ
aiua-13277	93	21	-	-	PUNCT
aiua-13277	93	22	greater	great	ADJ
aiua-13277	93	23	concentration	concentration	NOUN
aiua-13277	93	24	than	than	ADP
aiua-13277	93	25	with	with	ADP
aiua-13277	93	26	7	7	NUM
aiua-13277	93	27	-	-	PUNCT
aiua-13277	93	28	methylxanthine	methylxanthine	NOUN
aiua-13277	93	29	;	;	PUNCT
aiua-13277	93	30	7	7	NUM
aiua-13277	93	31	-	-	PUNCT
aiua-13277	93	32	methyluric	methyluric	ADJ
aiua-13277	93	33	acid	acid	NOUN
aiua-13277	93	34	has	have	VERB
aiua-13277	93	35	a	a	DET
aiua-13277	93	36	slightly	slightly	ADV
aiua-13277	93	37	stronger	strong	ADJ
aiua-13277	93	38	effect	effect	NOUN
aiua-13277	93	39	than	than	ADP
aiua-13277	93	40	3	3	NUM
aiua-13277	93	41	-	-	NUM
aiua-13277	93	42	methylxanthine	methylxanthine	NOUN
aiua-13277	93	43	,	,	PUNCT
aiua-13277	93	44	but	but	CCONJ
aiua-13277	93	45	its	its	PRON
aiua-13277	93	46	plasma	plasma	NOUN
aiua-13277	93	47	levels	level	NOUN
aiua-13277	93	48	are	be	AUX
aiua-13277	93	49	negligible	negligible	ADJ
aiua-13277	93	50	.	.	PUNCT
aiua-13277	94	1	for	for	ADP
aiua-13277	94	2	this	this	DET
aiua-13277	94	3	reason	reason	NOUN
aiua-13277	94	4	,	,	PUNCT
aiua-13277	94	5	consumption	consumption	NOUN
aiua-13277	94	6	of	of	ADP
aiua-13277	94	7	7	7	NUM
aiua-13277	94	8	-	-	PUNCT
aiua-13277	94	9	methylxanthine	methylxanthine	ADJ
aiua-13277	94	10	(	(	PUNCT
aiua-13277	94	11	or	or	CCONJ
aiua-13277	94	12	theobromine	theobromine	NOUN
aiua-13277	94	13	)	)	PUNCT
aiua-13277	94	14	has	have	VERB
aiua-13277	94	15	the	the	DET
aiua-13277	94	16	potential	potential	NOUN
aiua-13277	94	17	for	for	ADP
aiua-13277	94	18	preventing	prevent	VERB
aiua-13277	94	19	the	the	DET
aiua-13277	94	20	crystallization	crystallization	NOUN
aiua-13277	94	21	of	of	ADP
aiua-13277	94	22	sodium	sodium	NOUN
aiua-13277	94	23	urate	urate	NOUN
aiua-13277	94	24	and	and	CCONJ
aiua-13277	94	25	the	the	DET
aiua-13277	94	26	development	development	NOUN
aiua-13277	94	27	of	of	ADP
aiua-13277	94	28	gout	gout	NOUN
aiua-13277	94	29	.	.	PUNCT
aiua-13277	95	1	regarding	regard	VERB
aiua-13277	95	2	the	the	DET
aiua-13277	95	3	safety	safety	NOUN
aiua-13277	95	4	of	of	ADP
aiua-13277	95	5	the	the	DET
aiua-13277	95	6	treatment	treatment	NOUN
aiua-13277	95	7	of	of	ADP
aiua-13277	95	8	7	7	NUM
aiua-13277	95	9	-	-	PUNCT
aiua-13277	95	10	methylxanthine	methylxanthine	NOUN
aiua-13277	95	11	,	,	PUNCT
aiua-13277	95	12	studies	study	NOUN
aiua-13277	95	13	documented	document	VERB
aiua-13277	95	14	that	that	SCONJ
aiua-13277	95	15	it	it	PRON
aiua-13277	95	16	has	have	VERB
aiua-13277	95	17	no	no	DET
aiua-13277	95	18	toxic	toxic	ADJ
aiua-13277	95	19	effects	effect	NOUN
aiua-13277	95	20	up	up	ADP
aiua-13277	95	21	to	to	ADP
aiua-13277	95	22	an	an	DET
aiua-13277	95	23	oral	oral	ADJ
aiua-13277	95	24	dose	dose	NOUN
aiua-13277	95	25	of	of	ADP
aiua-13277	95	26	1000	1000	NUM
aiua-13277	95	27	mg	mg	PROPN
aiua-13277	95	28	/	/	SYM
aiua-13277	95	29	kg	kg	PROPN
aiua-13277	95	30	of	of	ADP
aiua-13277	95	31	weight	weight	NOUN
aiua-13277	95	32	indicating	indicate	VERB
aiua-13277	95	33	that	that	SCONJ
aiua-13277	95	34	the	the	DET
aiua-13277	95	35	consumption	consumption	NOUN
aiua-13277	95	36	of	of	ADP
aiua-13277	95	37	400	400	NUM
aiua-13277	95	38	mg	mg	NUM
aiua-13277	95	39	three	three	NUM
aiua-13277	95	40	times	time	NOUN
aiua-13277	95	41	per	per	ADP
aiua-13277	95	42	day	day	NOUN
aiua-13277	95	43	that	that	PRON
aiua-13277	95	44	should	should	AUX
aiua-13277	95	45	be	be	AUX
aiua-13277	95	46	requested	request	VERB
aiua-13277	95	47	to	to	PART
aiua-13277	95	48	prevent	prevent	VERB
aiua-13277	95	49	gout	gout	NOUN
aiua-13277	95	50	seems	seem	VERB
aiua-13277	95	51	to	to	PART
aiua-13277	95	52	be	be	AUX
aiua-13277	95	53	safe	safe	ADJ
aiua-13277	95	54	.	.	PUNCT
aiua-13277	96	1	conclusions	conclusion	NOUN
aiua-13277	96	2	theobromine	theobromine	NOUN
aiua-13277	96	3	is	be	AUX
aiua-13277	96	4	a	a	DET
aiua-13277	96	5	natural	natural	ADJ
aiua-13277	96	6	product	product	NOUN
aiua-13277	96	7	that	that	PRON
aiua-13277	96	8	has	have	VERB
aiua-13277	96	9	several	several	ADJ
aiua-13277	96	10	potential	potential	ADJ
aiua-13277	96	11	therapeutic	therapeutic	ADJ
aiua-13277	96	12	applications	application	NOUN
aiua-13277	96	13	.	.	PUNCT
aiua-13277	97	1	the	the	DET
aiua-13277	97	2	use	use	NOUN
aiua-13277	97	3	for	for	ADP
aiua-13277	97	4	the	the	DET
aiua-13277	97	5	treatment	treatment	NOUN
aiua-13277	97	6	of	of	ADP
aiua-13277	97	7	uric	uric	ADJ
aiua-13277	97	8	stones	stone	NOUN
aiua-13277	97	9	is	be	AUX
aiua-13277	97	10	the	the	DET
aiua-13277	97	11	most	most	ADV
aiua-13277	97	12	promising	promising	ADJ
aiua-13277	97	13	because	because	SCONJ
aiua-13277	97	14	it	it	PRON
aiua-13277	97	15	allows	allow	VERB
aiua-13277	97	16	the	the	DET
aiua-13277	97	17	dissolution	dissolution	NOUN
aiua-13277	97	18	of	of	ADP
aiua-13277	97	19	uric	uric	ADJ
aiua-13277	97	20	acid	acid	NOUN
aiua-13277	97	21	stones	stone	NOUN
aiua-13277	97	22	faster	fast	ADV
aiua-13277	97	23	with	with	ADP
aiua-13277	97	24	the	the	DET
aiua-13277	97	25	use	use	NOUN
aiua-13277	97	26	of	of	ADP
aiua-13277	97	27	lower	low	ADJ
aiua-13277	97	28	doses	dose	NOUN
aiua-13277	97	29	of	of	ADP
aiua-13277	97	30	alkalizers	alkalizer	NOUN
aiua-13277	97	31	.	.	PUNCT
aiua-13277	98	1	however	however	ADV
aiua-13277	98	2	,	,	PUNCT
aiua-13277	98	3	clinical	clinical	ADJ
aiua-13277	98	4	efficacy	efficacy	NOUN
aiua-13277	98	5	must	must	AUX
aiua-13277	98	6	be	be	AUX
aiua-13277	98	7	confirmed	confirm	VERB
aiua-13277	98	8	by	by	ADP
aiua-13277	98	9	randomized	randomize	VERB
aiua-13277	98	10	clinical	clinical	ADJ
aiua-13277	98	11	trials	trial	NOUN
aiua-13277	98	12	.	.	PUNCT
aiua-13277	99	1	treatment	treatment	NOUN
aiua-13277	99	2	with	with	ADP
aiua-13277	99	3	theobromine	theobromine	NOUN
aiua-13277	99	4	or	or	CCONJ
aiua-13277	99	5	its	its	PRON
aiua-13277	99	6	derivatives	derivative	NOUN
aiua-13277	99	7	could	could	AUX
aiua-13277	99	8	be	be	AUX
aiua-13277	99	9	used	use	VERB
aiua-13277	99	10	in	in	ADP
aiua-13277	99	11	the	the	DET
aiua-13277	99	12	treatment	treatment	NOUN
aiua-13277	99	13	of	of	ADP
aiua-13277	99	14	xanthinuria	xanthinuria	NOUN
aiua-13277	99	15	or	or	CCONJ
aiua-13277	99	16	gout	gout	NOUN
aiua-13277	99	17	.	.	PUNCT
aiua-13277	100	1	references	reference	NOUN
aiua-13277	100	2	1	1	NUM
aiua-13277	100	3	.	.	PUNCT
aiua-13277	100	4	craig	craig	PROPN
aiua-13277	100	5	wj	wj	PROPN
aiua-13277	100	6	,	,	PUNCT
aiua-13277	100	7	nguyen	nguyen	PROPN
aiua-13277	100	8	tt	tt	PROPN
aiua-13277	100	9	.	.	PUNCT
aiua-13277	100	10	caffeine	caffeine	PROPN
aiua-13277	100	11	and	and	CCONJ
aiua-13277	100	12	theobromine	theobromine	ADJ
aiua-13277	100	13	levels	level	NOUN
aiua-13277	100	14	in	in	ADP
aiua-13277	100	15	cocoa	cocoa	NOUN
aiua-13277	100	16	and	and	CCONJ
aiua-13277	100	17	carob	carob	NOUN
aiua-13277	100	18	products	product	NOUN
aiua-13277	100	19	.	.	PUNCT
aiua-13277	101	1	j	j	PROPN
aiua-13277	101	2	food	food	PROPN
aiua-13277	101	3	sci	sci	PROPN
aiua-13277	101	4	.	.	PROPN
aiua-13277	101	5	1984	1984	NUM
aiua-13277	101	6	;	;	PUNCT
aiua-13277	101	7	49:302	49:302	NUM
aiua-13277	101	8	-	-	SYM
aiua-13277	101	9	303	303	NUM
aiua-13277	101	10	.	.	NOUN
aiua-13277	102	1	2	2	NUM
aiua-13277	102	2	.	.	X
aiua-13277	102	3	martínez	martínez	NOUN
aiua-13277	102	4	-	-	PUNCT
aiua-13277	102	5	lópez	lópez	PROPN
aiua-13277	102	6	s	s	NOUN
aiua-13277	102	7	,	,	PUNCT
aiua-13277	102	8	sarriá	sarriá	NOUN
aiua-13277	102	9	b	b	NUM
aiua-13277	102	10	,	,	PUNCT
aiua-13277	102	11	gómez	gómez	NOUN
aiua-13277	102	12	-	-	PUNCT
aiua-13277	102	13	juaristi	juaristi	NOUN
aiua-13277	102	14	m	m	PROPN
aiua-13277	102	15	,	,	PUNCT
aiua-13277	102	16	et	et	PROPN
aiua-13277	102	17	al	al	PROPN
aiua-13277	102	18	.	.	PUNCT
aiua-13277	102	19	theobromine	theobromine	NOUN
aiua-13277	102	20	,	,	PUNCT
aiua-13277	102	21	caffeine	caffeine	NOUN
aiua-13277	102	22	,	,	PUNCT
aiua-13277	102	23	and	and	CCONJ
aiua-13277	102	24	theophylline	theophylline	NOUN
aiua-13277	102	25	metabolites	metabolite	NOUN
aiua-13277	102	26	in	in	ADP
aiua-13277	102	27	human	human	ADJ
aiua-13277	102	28	plasma	plasma	NOUN
aiua-13277	102	29	and	and	CCONJ
aiua-13277	102	30	urine	urine	NOUN
aiua-13277	102	31	after	after	ADP
aiua-13277	102	32	consumption	consumption	NOUN
aiua-13277	102	33	of	of	ADP
aiua-13277	102	34	soluble	soluble	ADJ
aiua-13277	102	35	cocoa	cocoa	NOUN
aiua-13277	102	36	products	product	NOUN
aiua-13277	102	37	with	with	ADP
aiua-13277	102	38	different	different	ADJ
aiua-13277	102	39	methylxanthine	methylxanthine	ADJ
aiua-13277	102	40	contents	content	NOUN
aiua-13277	102	41	.	.	PUNCT
aiua-13277	103	1	food	food	NOUN
aiua-13277	103	2	res	re	NOUN
aiua-13277	103	3	.	.	PUNCT
aiua-13277	104	1	int	int	NOUN
aiua-13277	104	2	.	.	PUNCT
aiua-13277	105	1	2014	2014	NUM
aiua-13277	105	2	;	;	PUNCT
aiua-13277	105	3	63:446	63:446	X
aiua-13277	105	4	-	-	SYM
aiua-13277	105	5	455	455	NUM
aiua-13277	105	6	.	.	PUNCT
aiua-13277	106	1	3	3	X
aiua-13277	106	2	.	.	X
aiua-13277	106	3	gates	gates	PROPN
aiua-13277	106	4	s	s	PROPN
aiua-13277	106	5	,	,	PUNCT
aiua-13277	106	6	miners	miner	NOUN
aiua-13277	106	7	jo	jo	PROPN
aiua-13277	106	8	.	.	PUNCT
aiua-13277	106	9	cytochrome	cytochrome	PROPN
aiua-13277	106	10	p450	p450	PROPN
aiua-13277	106	11	isoform	isoform	NOUN
aiua-13277	106	12	selectivity	selectivity	NOUN
aiua-13277	106	13	in	in	ADP
aiua-13277	106	14	human	human	ADJ
aiua-13277	106	15	hepatic	hepatic	ADJ
aiua-13277	106	16	theobromine	theobromine	ADJ
aiua-13277	106	17	metabolism	metabolism	NOUN
aiua-13277	106	18	.	.	PUNCT
aiua-13277	107	1	br	br	PROPN
aiua-13277	108	1	j	j	PROPN
aiua-13277	108	2	clin	clin	PROPN
aiua-13277	108	3	pharmacol	pharmacol	PROPN
aiua-13277	108	4	.	.	PUNCT
aiua-13277	108	5	1999	1999	NUM
aiua-13277	108	6	;	;	PUNCT
aiua-13277	108	7	47:299	47:299	NUM
aiua-13277	108	8	-	-	SYM
aiua-13277	108	9	305	305	NUM
aiua-13277	108	10	.	.	PUNCT
aiua-13277	109	1	4	4	NUM
aiua-13277	109	2	.	.	X
aiua-13277	109	3	tarka	tarka	PROPN
aiua-13277	109	4	sm	sm	PROPN
aiua-13277	109	5	,	,	PUNCT
aiua-13277	109	6	arnaud	arnaud	PROPN
aiua-13277	109	7	mj	mj	PROPN
aiua-13277	109	8	,	,	PUNCT
aiua-13277	109	9	dvorchik	dvorchik	ADJ
aiua-13277	109	10	bh	bh	NOUN
aiua-13277	109	11	,	,	PUNCT
aiua-13277	109	12	vesell	vesell	PROPN
aiua-13277	109	13	es	es	NOUN
aiua-13277	109	14	.	.	PUNCT
aiua-13277	109	15	theobromine	theobromine	ADJ
aiua-13277	109	16	kinetics	kinetic	NOUN
aiua-13277	109	17	and	and	CCONJ
aiua-13277	109	18	metabolic	metabolic	NOUN
aiua-13277	109	19	disposition	disposition	NOUN
aiua-13277	109	20	.	.	PUNCT
aiua-13277	110	1	clin	clin	PROPN
aiua-13277	110	2	pharmacol	pharmacol	PROPN
aiua-13277	110	3	ther	ther	ADV
aiua-13277	110	4	.	.	PUNCT
aiua-13277	111	1	1983	1983	NUM
aiua-13277	111	2	;	;	PUNCT
aiua-13277	111	3	34:546	34:546	NUM
aiua-13277	111	4	-	-	SYM
aiua-13277	111	5	555	555	NUM
aiua-13277	111	6	.	.	NOUN
aiua-13277	112	1	5	5	NUM
aiua-13277	112	2	.	.	PUNCT
aiua-13277	112	3	rodopoulos	rodopoulo	NOUN
aiua-13277	112	4	n	n	CCONJ
aiua-13277	112	5	,	,	PUNCT
aiua-13277	112	6	höjvall	höjvall	PROPN
aiua-13277	112	7	l	l	PROPN
aiua-13277	112	8	,	,	PUNCT
aiua-13277	112	9	norman	norman	PROPN
aiua-13277	112	10	a.	a.	NOUN
aiua-13277	112	11	elimination	elimination	NOUN
aiua-13277	112	12	of	of	ADP
aiua-13277	112	13	theobromine	theobromine	ADJ
aiua-13277	112	14	metabolites	metabolite	NOUN
aiua-13277	112	15	in	in	ADP
aiua-13277	112	16	healthy	healthy	ADJ
aiua-13277	112	17	adults	adult	NOUN
aiua-13277	112	18	.	.	PUNCT
aiua-13277	113	1	scand	scand	PROPN
aiua-13277	113	2	j	j	PROPN
aiua-13277	113	3	clin	clin	PROPN
aiua-13277	113	4	lab	lab	PROPN
aiua-13277	113	5	invest	invest	VERB
aiua-13277	113	6	.	.	PUNCT
aiua-13277	114	1	1996	1996	NUM
aiua-13277	114	2	;	;	PUNCT
aiua-13277	114	3	56:373383	56:373383	X
aiua-13277	114	4	.	.	NOUN
aiua-13277	114	5	6	6	NUM
aiua-13277	114	6	.	.	X
aiua-13277	114	7	lelo	lelo	VERB
aiua-13277	114	8	a	a	PRON
aiua-13277	114	9	,	,	PUNCT
aiua-13277	114	10	birkett	birkett	PROPN
aiua-13277	114	11	dj	dj	PROPN
aiua-13277	114	12	,	,	PUNCT
aiua-13277	114	13	robson	robson	PROPN
aiua-13277	114	14	ra	ra	PROPN
aiua-13277	114	15	,	,	PUNCT
aiua-13277	114	16	miners	miner	NOUN
aiua-13277	114	17	jo	jo	PROPN
aiua-13277	114	18	.	.	PUNCT
aiua-13277	115	1	comparative	comparative	ADJ
aiua-13277	115	2	pharmacokinetics	pharmacokinetic	NOUN
aiua-13277	115	3	of	of	ADP
aiua-13277	115	4	caffeine	caffeine	NOUN
aiua-13277	115	5	and	and	CCONJ
aiua-13277	115	6	its	its	PRON
aiua-13277	115	7	primary	primary	ADJ
aiua-13277	115	8	demethylated	demethylated	ADJ
aiua-13277	115	9	metabolites	metabolite	NOUN
aiua-13277	115	10	paraxanthine	paraxanthine	NOUN
aiua-13277	115	11	,	,	PUNCT
aiua-13277	115	12	theobromine	theobromine	NOUN
aiua-13277	115	13	and	and	CCONJ
aiua-13277	115	14	theophylline	theophylline	NOUN
aiua-13277	115	15	in	in	ADP
aiua-13277	115	16	man	man	NOUN
aiua-13277	115	17	.	.	PUNCT
aiua-13277	116	1	br	br	PROPN
aiua-13277	117	1	j	j	PROPN
aiua-13277	117	2	clin	clin	PROPN
aiua-13277	117	3	pharmacol	pharmacol	PROPN
aiua-13277	117	4	.	.	PUNCT
aiua-13277	117	5	1986	1986	NUM
aiua-13277	117	6	;	;	PUNCT
aiua-13277	117	7	22:177	22:177	NUM
aiua-13277	117	8	-	-	SYM
aiua-13277	117	9	182	182	NUM
aiua-13277	117	10	.	.	PUNCT
aiua-13277	118	1	7	7	X
aiua-13277	118	2	.	.	X
aiua-13277	118	3	tang	tang	PROPN
aiua-13277	118	4	-	-	PUNCT
aiua-13277	118	5	liu	liu	PROPN
aiua-13277	118	6	ds	ds	PROPN
aiua-13277	118	7	,	,	PUNCT
aiua-13277	118	8	williams	williams	PROPN
aiua-13277	118	9	rl	rl	PROPN
aiua-13277	118	10	,	,	PUNCT
aiua-13277	118	11	riegelman	riegelman	PROPN
aiua-13277	118	12	s.	s.	PROPN
aiua-13277	118	13	disposition	disposition	NOUN
aiua-13277	118	14	of	of	ADP
aiua-13277	118	15	caffeine	caffeine	NOUN
aiua-13277	118	16	and	and	CCONJ
aiua-13277	118	17	its	its	PRON
aiua-13277	118	18	metabolites	metabolite	NOUN
aiua-13277	118	19	in	in	ADP
aiua-13277	118	20	man	man	NOUN
aiua-13277	118	21	.	.	PUNCT
aiua-13277	119	1	j	j	PROPN
aiua-13277	119	2	pharm	pharm	PROPN
aiua-13277	119	3	exp	exp	NOUN
aiua-13277	119	4	ther	ther	ADV
aiua-13277	119	5	.	.	PUNCT
aiua-13277	120	1	1983	1983	NUM
aiua-13277	120	2	;	;	PUNCT
aiua-13277	121	1	224:180	224:180	NUM
aiua-13277	121	2	-	-	SYM
aiua-13277	121	3	185	185	NUM
aiua-13277	121	4	.	.	PUNCT
aiua-13277	121	5	8	8	NUM
aiua-13277	121	6	.	.	PUNCT
aiua-13277	121	7	mitchell	mitchell	PROPN
aiua-13277	121	8	es	es	PROPN
aiua-13277	121	9	,	,	PUNCT
aiua-13277	121	10	slettenaar	slettenaar	NOUN
aiua-13277	121	11	m	m	PROPN
aiua-13277	121	12	,	,	PUNCT
aiua-13277	121	13	vd	vd	PROPN
aiua-13277	121	14	meer	meer	PROPN
aiua-13277	121	15	n	n	CCONJ
aiua-13277	121	16	,	,	PUNCT
aiua-13277	121	17	et	et	PROPN
aiua-13277	121	18	al	al	PROPN
aiua-13277	121	19	.	.	PROPN
aiua-13277	121	20	differential	differential	ADJ
aiua-13277	121	21	contributions	contribution	NOUN
aiua-13277	121	22	of	of	ADP
aiua-13277	121	23	theobromine	theobromine	NOUN
aiua-13277	121	24	and	and	CCONJ
aiua-13277	121	25	caffeine	caffeine	NOUN
aiua-13277	121	26	on	on	ADP
aiua-13277	121	27	mood	mood	NOUN
aiua-13277	121	28	,	,	PUNCT
aiua-13277	121	29	psychomotor	psychomotor	NOUN
aiua-13277	121	30	performance	performance	NOUN
aiua-13277	121	31	and	and	CCONJ
aiua-13277	121	32	blood	blood	NOUN
aiua-13277	121	33	pressure	pressure	NOUN
aiua-13277	121	34	.	.	PUNCT
aiua-13277	122	1	physiol	physiol	PROPN
aiua-13277	122	2	behav	behav	PROPN
aiua-13277	122	3	.	.	PUNCT
aiua-13277	123	1	2011	2011	NUM
aiua-13277	123	2	;	;	PUNCT
aiua-13277	123	3	104:816	104:816	NUM
aiua-13277	123	4	-	-	SYM
aiua-13277	123	5	822	822	NUM
aiua-13277	123	6	.	.	PUNCT
aiua-13277	124	1	9	9	X
aiua-13277	124	2	.	.	X
aiua-13277	124	3	finlay	finlay	VERB
aiua-13277	124	4	f	f	PROPN
aiua-13277	124	5	,	,	PUNCT
aiua-13277	124	6	guiton	guiton	PROPN
aiua-13277	124	7	s.	s.	PROPN
aiua-13277	124	8	chocolate	chocolate	PROPN
aiua-13277	124	9	poisoning	poisoning	NOUN
aiua-13277	124	10	.	.	PUNCT
aiua-13277	125	1	bmj	bmj	PROPN
aiua-13277	125	2	.	.	PUNCT
aiua-13277	125	3	2005	2005	NUM
aiua-13277	125	4	;	;	PUNCT
aiua-13277	125	5	331:633	331:633	NOUN
aiua-13277	125	6	.	.	PUNCT
aiua-13277	126	1	archivio	archivio	NOUN
aiua-13277	126	2	italiano	italiano	PROPN
aiua-13277	126	3	di	di	PROPN
aiua-13277	126	4	urologia	urologia	PROPN
aiua-13277	126	5	e	e	PROPN
aiua-13277	126	6	andrologia	andrologia	NOUN
aiua-13277	126	7	2024	2024	NUM
aiua-13277	126	8	;	;	PUNCT
aiua-13277	126	9	96(4):13277	96(4):13277	NUM
aiua-13277	126	10	a.	a.	NOUN
aiua-13277	126	11	trinchieri	trinchieri	PROPN
aiua-13277	126	12	4	4	NUM
aiua-13277	126	13	10	10	NUM
aiua-13277	126	14	.	.	PUNCT
aiua-13277	127	1	halfdanarson	halfdanarson	NOUN
aiua-13277	127	2	tr	tr	VERB
aiua-13277	127	3	,	,	PUNCT
aiua-13277	127	4	jatoi	jatoi	NOUN
aiua-13277	127	5	a.	a.	NOUN
aiua-13277	127	6	chocolate	chocolate	PROPN
aiua-13277	127	7	as	as	ADP
aiua-13277	127	8	a	a	DET
aiua-13277	127	9	cough	cough	NOUN
aiua-13277	127	10	suppressant	suppressant	NOUN
aiua-13277	127	11	:	:	PUNCT
aiua-13277	127	12	rationale	rationale	NOUN
aiua-13277	127	13	and	and	CCONJ
aiua-13277	127	14	justification	justification	NOUN
aiua-13277	127	15	for	for	ADP
aiua-13277	127	16	an	an	DET
aiua-13277	127	17	upcoming	upcoming	ADJ
aiua-13277	127	18	clinical	clinical	ADJ
aiua-13277	127	19	trial	trial	NOUN
aiua-13277	127	20	.	.	PUNCT
aiua-13277	128	1	support	support	NOUN
aiua-13277	128	2	cancer	cancer	NOUN
aiua-13277	128	3	ther	ther	ADV
aiua-13277	128	4	.	.	PUNCT
aiua-13277	129	1	2007	2007	NUM
aiua-13277	129	2	;	;	PUNCT
aiua-13277	129	3	4:119	4:119	NUM
aiua-13277	129	4	-	-	SYM
aiua-13277	129	5	122	122	NUM
aiua-13277	129	6	.	.	PUNCT
aiua-13277	130	1	11	11	NUM
aiua-13277	130	2	.	.	PUNCT
aiua-13277	131	1	khan	khan	PROPN
aiua-13277	131	2	n	n	CCONJ
aiua-13277	131	3	,	,	PUNCT
aiua-13277	131	4	monagas	monagas	PROPN
aiua-13277	131	5	m	m	PROPN
aiua-13277	131	6	,	,	PUNCT
aiua-13277	131	7	andres	andres	PROPN
aiua-13277	131	8	-	-	PUNCT
aiua-13277	131	9	lacueva	lacueva	PROPN
aiua-13277	131	10	c	c	PROPN
aiua-13277	131	11	,	,	PUNCT
aiua-13277	131	12	et	et	PROPN
aiua-13277	131	13	al	al	PROPN
aiua-13277	131	14	.	.	PROPN
aiua-13277	132	1	regular	regular	ADJ
aiua-13277	132	2	consumption	consumption	NOUN
aiua-13277	132	3	of	of	ADP
aiua-13277	132	4	cocoa	cocoa	NOUN
aiua-13277	132	5	powder	powder	NOUN
aiua-13277	132	6	with	with	ADP
aiua-13277	132	7	milk	milk	NOUN
aiua-13277	132	8	increases	increase	NOUN
aiua-13277	132	9	hdl	hdl	PROPN
aiua-13277	132	10	cholesterol	cholesterol	NOUN
aiua-13277	132	11	and	and	CCONJ
aiua-13277	132	12	reduces	reduce	VERB
aiua-13277	132	13	oxidized	oxidize	VERB
aiua-13277	132	14	ldl	ldl	NOUN
aiua-13277	132	15	levels	level	NOUN
aiua-13277	132	16	in	in	ADP
aiua-13277	132	17	subjects	subject	NOUN
aiua-13277	132	18	at	at	ADP
aiua-13277	132	19	high	high	ADJ
aiua-13277	132	20	-	-	PUNCT
aiua-13277	132	21	risk	risk	NOUN
aiua-13277	132	22	of	of	ADP
aiua-13277	132	23	cardiovascular	cardiovascular	ADJ
aiua-13277	132	24	disease	disease	NOUN
aiua-13277	132	25	.	.	PUNCT
aiua-13277	133	1	nutr	nutr	PROPN
aiua-13277	133	2	metab	metab	PROPN
aiua-13277	133	3	cardiovasc	cardiovasc	PROPN
aiua-13277	133	4	dis	dis	PROPN
aiua-13277	133	5	.	.	PUNCT
aiua-13277	133	6	2012	2012	NUM
aiua-13277	133	7	;	;	PUNCT
aiua-13277	133	8	22:1046	22:1046	NUM
aiua-13277	133	9	-	-	SYM
aiua-13277	133	10	1053	1053	NUM
aiua-13277	133	11	.	.	PUNCT
aiua-13277	134	1	12	12	NUM
aiua-13277	134	2	.	.	PUNCT
aiua-13277	135	1	neufingerl	neufingerl	PROPN
aiua-13277	135	2	n	n	SYM
aiua-13277	135	3	,	,	PUNCT
aiua-13277	135	4	zebregs	zebreg	NOUN
aiua-13277	135	5	ye	ye	NUM
aiua-13277	135	6	,	,	PUNCT
aiua-13277	135	7	schuring	schure	VERB
aiua-13277	135	8	ea	ea	ADP
aiua-13277	135	9	,	,	PUNCT
aiua-13277	135	10	trautwein	trautwein	VERB
aiua-13277	135	11	ea	ea	NOUN
aiua-13277	135	12	.	.	PUNCT
aiua-13277	135	13	effect	effect	NOUN
aiua-13277	135	14	of	of	ADP
aiua-13277	135	15	cocoa	cocoa	NOUN
aiua-13277	135	16	and	and	CCONJ
aiua-13277	135	17	theobromine	theobromine	ADJ
aiua-13277	135	18	consumption	consumption	NOUN
aiua-13277	135	19	on	on	ADP
aiua-13277	135	20	serum	serum	NOUN
aiua-13277	135	21	hdl	hdl	PROPN
aiua-13277	135	22	-	-	PUNCT
aiua-13277	135	23	cholesterol	cholesterol	NOUN
aiua-13277	135	24	concentrations	concentration	NOUN
aiua-13277	135	25	:	:	PUNCT
aiua-13277	135	26	a	a	DET
aiua-13277	135	27	randomized	randomized	ADJ
aiua-13277	135	28	controlled	control	VERB
aiua-13277	135	29	trial	trial	NOUN
aiua-13277	135	30	.	.	PUNCT
aiua-13277	136	1	am	be	AUX
aiua-13277	136	2	j	j	PROPN
aiua-13277	136	3	clin	clin	PROPN
aiua-13277	136	4	nutr	nutr	PROPN
aiua-13277	136	5	.	.	PROPN
aiua-13277	136	6	2013	2013	NUM
aiua-13277	136	7	;	;	PUNCT
aiua-13277	136	8	97:1201	97:1201	NUM
aiua-13277	136	9	-	-	PUNCT
aiua-13277	136	10	1209	1209	NUM
aiua-13277	136	11	.	.	PUNCT
aiua-13277	137	1	13	13	NUM
aiua-13277	137	2	.	.	PUNCT
aiua-13277	137	3	kargul	kargul	PROPN
aiua-13277	137	4	b	b	PROPN
aiua-13277	137	5	,	,	PUNCT
aiua-13277	137	6	ozcan	ozcan	PROPN
aiua-13277	137	7	m	m	PROPN
aiua-13277	137	8	,	,	PUNCT
aiua-13277	137	9	peker	peker	NOUN
aiua-13277	137	10	s	s	PROPN
aiua-13277	137	11	,	,	PUNCT
aiua-13277	137	12	et	et	PROPN
aiua-13277	137	13	al	al	PROPN
aiua-13277	137	14	.	.	PUNCT
aiua-13277	137	15	evaluation	evaluation	NOUN
aiua-13277	137	16	of	of	ADP
aiua-13277	137	17	human	human	ADJ
aiua-13277	137	18	enamel	enamel	NOUN
aiua-13277	137	19	surfaces	surface	NOUN
aiua-13277	137	20	treated	treat	VERB
aiua-13277	137	21	with	with	ADP
aiua-13277	137	22	theobromine	theobromine	NOUN
aiua-13277	137	23	:	:	PUNCT
aiua-13277	137	24	a	a	DET
aiua-13277	137	25	pilot	pilot	NOUN
aiua-13277	137	26	study	study	NOUN
aiua-13277	137	27	.	.	PUNCT
aiua-13277	138	1	oral	oral	ADJ
aiua-13277	138	2	health	health	PROPN
aiua-13277	138	3	prev	prev	PROPN
aiua-13277	138	4	dent	dent	NOUN
aiua-13277	138	5	.	.	PUNCT
aiua-13277	139	1	2012	2012	NUM
aiua-13277	139	2	;	;	PUNCT
aiua-13277	139	3	10:275	10:275	PROPN
aiua-13277	139	4	-	-	SYM
aiua-13277	139	5	282	282	NUM
aiua-13277	139	6	.	.	PUNCT
aiua-13277	140	1	14	14	NUM
aiua-13277	140	2	.	.	PUNCT
aiua-13277	141	1	lai	lai	PROPN
aiua-13277	141	2	l	l	PROPN
aiua-13277	141	3	,	,	PUNCT
aiua-13277	141	4	trier	tri	ADJ
aiua-13277	141	5	k	k	PROPN
aiua-13277	141	6	,	,	PUNCT
aiua-13277	141	7	cui	cui	X
aiua-13277	141	8	dm	dm	PROPN
aiua-13277	141	9	.	.	PUNCT
aiua-13277	142	1	role	role	NOUN
aiua-13277	142	2	of	of	ADP
aiua-13277	142	3	7	7	NUM
aiua-13277	142	4	-	-	PUNCT
aiua-13277	142	5	methylxanthine	methylxanthine	NOUN
aiua-13277	142	6	in	in	ADP
aiua-13277	142	7	myopia	myopia	NOUN
aiua-13277	142	8	prevention	prevention	NOUN
aiua-13277	142	9	and	and	CCONJ
aiua-13277	142	10	control	control	PROPN
aiua-13277	142	11	:	:	PUNCT
aiua-13277	142	12	a	a	DET
aiua-13277	142	13	mini	mini	NOUN
aiua-13277	142	14	-	-	NOUN
aiua-13277	142	15	review	review	NOUN
aiua-13277	142	16	.	.	PUNCT
aiua-13277	143	1	int	int	NOUN
aiua-13277	144	1	j	j	PROPN
aiua-13277	144	2	ophthalmol	ophthalmol	PROPN
aiua-13277	144	3	.	.	PUNCT
aiua-13277	145	1	2023	2023	NUM
aiua-13277	145	2	;	;	PUNCT
aiua-13277	145	3	16:969976	16:969976	NUM
aiua-13277	145	4	.	.	PUNCT
aiua-13277	146	1	15	15	NUM
aiua-13277	146	2	.	.	PUNCT
aiua-13277	147	1	trinchieri	trinchieri	PROPN
aiua-13277	147	2	a	a	PROPN
aiua-13277	147	3	,	,	PUNCT
aiua-13277	147	4	montanari	montanari	PROPN
aiua-13277	147	5	e.	e.	PROPN
aiua-13277	147	6	prevalence	prevalence	PROPN
aiua-13277	147	7	of	of	ADP
aiua-13277	147	8	renal	renal	ADJ
aiua-13277	147	9	uric	uric	ADJ
aiua-13277	147	10	acid	acid	NOUN
aiua-13277	147	11	stones	stone	NOUN
aiua-13277	147	12	in	in	ADP
aiua-13277	147	13	the	the	DET
aiua-13277	147	14	adult	adult	NOUN
aiua-13277	147	15	.	.	PUNCT
aiua-13277	148	1	urolithiasis	urolithiasis	PROPN
aiua-13277	148	2	.	.	PUNCT
aiua-13277	149	1	2017	2017	NUM
aiua-13277	149	2	;	;	PUNCT
aiua-13277	149	3	45:553	45:553	NUM
aiua-13277	149	4	-	-	SYM
aiua-13277	149	5	562	562	NUM
aiua-13277	149	6	.	.	PUNCT
aiua-13277	150	1	16	16	NUM
aiua-13277	150	2	.	.	PUNCT
aiua-13277	151	1	brikowski	brikowski	PROPN
aiua-13277	151	2	th	th	PROPN
aiua-13277	151	3	,	,	PUNCT
aiua-13277	151	4	lotan	lotan	PROPN
aiua-13277	151	5	y	y	PROPN
aiua-13277	151	6	,	,	PUNCT
aiua-13277	151	7	pearle	pearle	VERB
aiua-13277	151	8	ms	ms	PROPN
aiua-13277	151	9	.	.	PROPN
aiua-13277	151	10	climate	climate	NOUN
aiua-13277	151	11	-	-	PUNCT
aiua-13277	151	12	related	relate	VERB
aiua-13277	151	13	increase	increase	NOUN
aiua-13277	151	14	in	in	ADP
aiua-13277	151	15	the	the	DET
aiua-13277	151	16	prevalence	prevalence	NOUN
aiua-13277	151	17	of	of	ADP
aiua-13277	151	18	urolithiasis	urolithiasis	NOUN
aiua-13277	151	19	in	in	ADP
aiua-13277	151	20	the	the	DET
aiua-13277	151	21	united	united	PROPN
aiua-13277	151	22	states	states	PROPN
aiua-13277	151	23	.	.	PUNCT
aiua-13277	152	1	proc	proc	PROPN
aiua-13277	152	2	natl	natl	PROPN
aiua-13277	152	3	acad	acad	PROPN
aiua-13277	152	4	sci	sci	PROPN
aiua-13277	152	5	u	u	PROPN
aiua-13277	152	6	s	s	NOUN
aiua-13277	152	7	a.	a.	NOUN
aiua-13277	152	8	2008	2008	NUM
aiua-13277	152	9	;	;	PUNCT
aiua-13277	152	10	105:9841	105:9841	NUM
aiua-13277	152	11	-	-	SYM
aiua-13277	152	12	9846	9846	NUM
aiua-13277	152	13	.	.	PUNCT
aiua-13277	153	1	17	17	NUM
aiua-13277	153	2	.	.	PUNCT
aiua-13277	154	1	trinchieri	trinchieri	PROPN
aiua-13277	154	2	a	a	PROPN
aiua-13277	154	3	,	,	PUNCT
aiua-13277	154	4	montanari	montanari	PROPN
aiua-13277	154	5	e.	e.	PROPN
aiua-13277	154	6	biochemical	biochemical	PROPN
aiua-13277	154	7	and	and	CCONJ
aiua-13277	154	8	dietary	dietary	ADJ
aiua-13277	154	9	factors	factor	NOUN
aiua-13277	154	10	of	of	ADP
aiua-13277	154	11	uric	uric	ADJ
aiua-13277	154	12	acid	acid	NOUN
aiua-13277	154	13	stone	stone	NOUN
aiua-13277	154	14	formation	formation	NOUN
aiua-13277	154	15	.	.	PUNCT
aiua-13277	155	1	urolithiasis	urolithiasis	NOUN
aiua-13277	155	2	.	.	PUNCT
aiua-13277	156	1	2018	2018	NUM
aiua-13277	156	2	;	;	PUNCT
aiua-13277	156	3	46:167	46:167	NUM
aiua-13277	156	4	-	-	SYM
aiua-13277	156	5	172	172	NUM
aiua-13277	156	6	.	.	PROPN
aiua-13277	156	7	18	18	NUM
aiua-13277	156	8	.	.	PUNCT
aiua-13277	157	1	wagner	wagner	PROPN
aiua-13277	157	2	ca	ca	PROPN
aiua-13277	157	3	,	,	PUNCT
aiua-13277	157	4	mohebbi	mohebbi	VERB
aiua-13277	157	5	n.	n.	PROPN
aiua-13277	157	6	urinary	urinary	ADJ
aiua-13277	157	7	ph	ph	NOUN
aiua-13277	157	8	and	and	CCONJ
aiua-13277	157	9	stone	stone	NOUN
aiua-13277	157	10	formation	formation	NOUN
aiua-13277	157	11	.	.	PUNCT
aiua-13277	158	1	j	j	PROPN
aiua-13277	158	2	nephrol	nephrol	NOUN
aiua-13277	158	3	.	.	PUNCT
aiua-13277	159	1	2010	2010	NUM
aiua-13277	159	2	;	;	PUNCT
aiua-13277	159	3	23(suppl	23(suppl	NUM
aiua-13277	159	4	16):s165	16):s165	NUM
aiua-13277	159	5	-	-	SYM
aiua-13277	159	6	169	169	NUM
aiua-13277	159	7	.	.	PUNCT
aiua-13277	160	1	19	19	NUM
aiua-13277	160	2	.	.	PUNCT
aiua-13277	161	1	grases	grase	NOUN
aiua-13277	161	2	f	f	PROPN
aiua-13277	161	3	,	,	PUNCT
aiua-13277	161	4	costa	costa	NOUN
aiua-13277	161	5	-	-	PUNCT
aiua-13277	161	6	bauza	bauza	NOUN
aiua-13277	161	7	a	a	NOUN
aiua-13277	161	8	,	,	PUNCT
aiua-13277	161	9	gomila	gomila	PROPN
aiua-13277	162	1	i	i	INTJ
aiua-13277	162	2	,	,	PUNCT
aiua-13277	162	3	et	et	PROPN
aiua-13277	162	4	al	al	PROPN
aiua-13277	162	5	.	.	PUNCT
aiua-13277	162	6	urinary	urinary	ADJ
aiua-13277	162	7	ph	ph	PROPN
aiua-13277	162	8	and	and	CCONJ
aiua-13277	162	9	renal	renal	ADJ
aiua-13277	162	10	lithiasis	lithiasis	NOUN
aiua-13277	162	11	.	.	PUNCT
aiua-13277	163	1	urol	urol	PROPN
aiua-13277	163	2	res	re	NOUN
aiua-13277	163	3	.	.	PROPN
aiua-13277	163	4	2012	2012	NUM
aiua-13277	163	5	;	;	PUNCT
aiua-13277	163	6	40:41	40:41	NUM
aiua-13277	163	7	-	-	SYM
aiua-13277	163	8	46	46	NUM
aiua-13277	163	9	.	.	NOUN
aiua-13277	164	1	20	20	NUM
aiua-13277	164	2	.	.	PUNCT
aiua-13277	165	1	trinchieri	trinchieri	PROPN
aiua-13277	165	2	a	a	PROPN
aiua-13277	165	3	,	,	PUNCT
aiua-13277	165	4	esposito	esposito	PROPN
aiua-13277	165	5	n	n	CCONJ
aiua-13277	165	6	,	,	PUNCT
aiua-13277	165	7	castelnuovo	castelnuovo	PROPN
aiua-13277	165	8	c.	c.	PROPN
aiua-13277	165	9	dissolution	dissolution	PROPN
aiua-13277	165	10	of	of	ADP
aiua-13277	165	11	radiolucent	radiolucent	ADJ
aiua-13277	165	12	renal	renal	ADJ
aiua-13277	165	13	stones	stone	NOUN
aiua-13277	165	14	by	by	ADP
aiua-13277	165	15	oral	oral	ADJ
aiua-13277	165	16	alkalinization	alkalinization	NOUN
aiua-13277	165	17	with	with	ADP
aiua-13277	165	18	potassium	potassium	NOUN
aiua-13277	165	19	citrate	citrate	NOUN
aiua-13277	165	20	/	/	SYM
aiua-13277	165	21	potassium	potassium	NOUN
aiua-13277	165	22	bicarbonate	bicarbonate	NOUN
aiua-13277	165	23	.	.	PUNCT
aiua-13277	166	1	arch	arch	PROPN
aiua-13277	166	2	ital	ital	PROPN
aiua-13277	166	3	urol	urol	PROPN
aiua-13277	166	4	androl	androl	PROPN
aiua-13277	166	5	.	.	PROPN
aiua-13277	166	6	2009	2009	NUM
aiua-13277	166	7	;	;	PUNCT
aiua-13277	166	8	81:188	81:188	NUM
aiua-13277	166	9	-	-	SYM
aiua-13277	166	10	91	91	NUM
aiua-13277	166	11	.	.	PUNCT
aiua-13277	167	1	21	21	NUM
aiua-13277	167	2	.	.	PUNCT
aiua-13277	167	3	burns	burns	PROPN
aiua-13277	167	4	jr	jr	PROPN
aiua-13277	167	5	,	,	PUNCT
aiua-13277	167	6	gauthier	gauthier	PROPN
aiua-13277	167	7	jf	jf	PROPN
aiua-13277	167	8	,	,	PUNCT
aiua-13277	167	9	finlayson	finlayson	PROPN
aiua-13277	167	10	b.	b.	PROPN
aiua-13277	167	11	dissolution	dissolution	PROPN
aiua-13277	167	12	kinetics	kinetic	NOUN
aiua-13277	167	13	of	of	ADP
aiua-13277	167	14	uric	uric	ADJ
aiua-13277	167	15	acid	acid	ADJ
aiua-13277	167	16	calculi	calculi	PROPN
aiua-13277	167	17	.	.	PUNCT
aiua-13277	168	1	j	j	PROPN
aiua-13277	168	2	urol	urol	PROPN
aiua-13277	168	3	.	.	PUNCT
aiua-13277	168	4	1984	1984	NUM
aiua-13277	168	5	;	;	PUNCT
aiua-13277	168	6	131:708	131:708	NUM
aiua-13277	168	7	-	-	PUNCT
aiua-13277	168	8	711	711	NUM
aiua-13277	168	9	.	.	PUNCT
aiua-13277	168	10	22	22	NUM
aiua-13277	168	11	.	.	PUNCT
aiua-13277	169	1	sadowska	sadowska	PROPN
aiua-13277	169	2	am	am	PROPN
aiua-13277	169	3	.	.	PUNCT
aiua-13277	170	1	n	n	CCONJ
aiua-13277	170	2	-	-	PUNCT
aiua-13277	170	3	acetylcysteine	acetylcysteine	NOUN
aiua-13277	170	4	mucolysis	mucolysis	NOUN
aiua-13277	170	5	in	in	ADP
aiua-13277	170	6	the	the	DET
aiua-13277	170	7	management	management	NOUN
aiua-13277	170	8	of	of	ADP
aiua-13277	170	9	chronic	chronic	ADJ
aiua-13277	170	10	obstructive	obstructive	ADJ
aiua-13277	170	11	pulmonary	pulmonary	ADJ
aiua-13277	170	12	disease	disease	NOUN
aiua-13277	170	13	.	.	PUNCT
aiua-13277	171	1	ther	ther	PROPN
aiua-13277	171	2	adv	adv	PROPN
aiua-13277	171	3	respir	respir	VERB
aiua-13277	171	4	dis	dis	PROPN
aiua-13277	171	5	.	.	PUNCT
aiua-13277	171	6	2012	2012	NUM
aiua-13277	171	7	;	;	PUNCT
aiua-13277	171	8	6:127	6:127	NUM
aiua-13277	171	9	-	-	SYM
aiua-13277	171	10	135	135	NUM
aiua-13277	171	11	.	.	PUNCT
aiua-13277	171	12	23	23	NUM
aiua-13277	171	13	.	.	PUNCT
aiua-13277	172	1	grases	grase	NOUN
aiua-13277	172	2	f	f	PROPN
aiua-13277	172	3	,	,	PUNCT
aiua-13277	172	4	ramis	ramis	PROPN
aiua-13277	172	5	m	m	PROPN
aiua-13277	172	6	,	,	PUNCT
aiua-13277	172	7	villacampa	villacampa	PROPN
aiua-13277	172	8	ai	ai	VERB
aiua-13277	172	9	,	,	PUNCT
aiua-13277	172	10	costa	costa	PROPN
aiua-13277	172	11	-	-	PUNCT
aiua-13277	172	12	bauzá	bauzá	PROPN
aiua-13277	172	13	a.	a.	PROPN
aiua-13277	172	14	uric	uric	PROPN
aiua-13277	172	15	acid	acid	PROPN
aiua-13277	173	1	urolithiasis	urolithiasis	NOUN
aiua-13277	173	2	and	and	CCONJ
aiua-13277	173	3	crystallization	crystallization	NOUN
aiua-13277	173	4	inhibitors	inhibitor	NOUN
aiua-13277	173	5	.	.	PUNCT
aiua-13277	174	1	urol	urol	PROPN
aiua-13277	174	2	int	int	PROPN
aiua-13277	174	3	.	.	PUNCT
aiua-13277	174	4	1999	1999	NUM
aiua-13277	174	5	;	;	PUNCT
aiua-13277	174	6	62:201204	62:201204	NUM
aiua-13277	174	7	.	.	X
aiua-13277	175	1	24	24	NUM
aiua-13277	175	2	.	.	PUNCT
aiua-13277	175	3	grases	grase	NOUN
aiua-13277	175	4	f	f	PROPN
aiua-13277	175	5	,	,	PUNCT
aiua-13277	175	6	rodriguez	rodriguez	PROPN
aiua-13277	175	7	a	a	X
aiua-13277	175	8	,	,	PUNCT
aiua-13277	175	9	costa	costa	ADJ
aiua-13277	175	10	-	-	PUNCT
aiua-13277	175	11	bauza	bauza	NOUN
aiua-13277	175	12	a.	a.	NOUN
aiua-13277	175	13	theobromine	theobromine	NOUN
aiua-13277	175	14	inhibits	inhibit	VERB
aiua-13277	175	15	uric	uric	ADJ
aiua-13277	175	16	acid	acid	NOUN
aiua-13277	175	17	crystallization	crystallization	NOUN
aiua-13277	175	18	.	.	PUNCT
aiua-13277	176	1	a	a	DET
aiua-13277	176	2	potential	potential	ADJ
aiua-13277	176	3	application	application	NOUN
aiua-13277	176	4	in	in	ADP
aiua-13277	176	5	the	the	DET
aiua-13277	176	6	treatment	treatment	NOUN
aiua-13277	176	7	of	of	ADP
aiua-13277	176	8	uric	uric	ADJ
aiua-13277	176	9	acid	acid	NOUN
aiua-13277	176	10	nephrolithiasis	nephrolithiasis	NOUN
aiua-13277	176	11	.	.	PUNCT
aiua-13277	177	1	plos	plos	PROPN
aiua-13277	177	2	one	one	NUM
aiua-13277	177	3	.	.	PUNCT
aiua-13277	177	4	2014	2014	NUM
aiua-13277	177	5	;	;	PUNCT
aiua-13277	177	6	9	9	NUM
aiua-13277	177	7	:	:	PUNCT
aiua-13277	177	8	e111184	e111184	NOUN
aiua-13277	177	9	.	.	PROPN
aiua-13277	177	10	25	25	NUM
aiua-13277	177	11	.	.	PUNCT
aiua-13277	178	1	costa	costa	NOUN
aiua-13277	178	2	-	-	PUNCT
aiua-13277	178	3	bauza	bauza	NOUN
aiua-13277	178	4	a	a	NOUN
aiua-13277	178	5	,	,	PUNCT
aiua-13277	178	6	grases	grase	NOUN
aiua-13277	178	7	f	f	PROPN
aiua-13277	178	8	,	,	PUNCT
aiua-13277	178	9	calvó	calvó	VERB
aiua-13277	178	10	p	p	PROPN
aiua-13277	178	11	,	,	PUNCT
aiua-13277	178	12	et	et	PROPN
aiua-13277	178	13	al	al	PROPN
aiua-13277	178	14	.	.	PROPN
aiua-13277	179	1	effect	effect	NOUN
aiua-13277	179	2	of	of	ADP
aiua-13277	179	3	consumption	consumption	NOUN
aiua-13277	179	4	of	of	ADP
aiua-13277	179	5	cocoa	cocoa	NOUN
aiua-13277	179	6	-	-	PUNCT
aiua-13277	179	7	derived	derive	VERB
aiua-13277	179	8	products	product	NOUN
aiua-13277	179	9	on	on	ADP
aiua-13277	179	10	uric	uric	ADJ
aiua-13277	179	11	acid	acid	NOUN
aiua-13277	179	12	crystallization	crystallization	NOUN
aiua-13277	179	13	in	in	ADP
aiua-13277	179	14	urine	urine	NOUN
aiua-13277	179	15	of	of	ADP
aiua-13277	179	16	healthy	healthy	ADJ
aiua-13277	179	17	volunteers	volunteer	NOUN
aiua-13277	179	18	.	.	PUNCT
aiua-13277	180	1	nutrients	nutrient	NOUN
aiua-13277	180	2	.	.	PUNCT
aiua-13277	180	3	2018	2018	NUM
aiua-13277	180	4	;	;	PUNCT
aiua-13277	180	5	10:1516	10:1516	NUM
aiua-13277	180	6	.	.	NOUN
aiua-13277	180	7	26	26	NUM
aiua-13277	180	8	.	.	PUNCT
aiua-13277	181	1	chattaraj	chattaraj	PROPN
aiua-13277	181	2	kg	kg	PROPN
aiua-13277	181	3	,	,	PUNCT
aiua-13277	181	4	paul	paul	PROPN
aiua-13277	181	5	s.	s.	PROPN
aiua-13277	181	6	inclusion	inclusion	PROPN
aiua-13277	181	7	of	of	ADP
aiua-13277	181	8	theobromine	theobromine	NOUN
aiua-13277	181	9	modifies	modify	VERB
aiua-13277	181	10	uric	uric	ADJ
aiua-13277	181	11	acid	acid	NOUN
aiua-13277	181	12	aggregation	aggregation	NOUN
aiua-13277	181	13	with	with	ADP
aiua-13277	181	14	possible	possible	ADJ
aiua-13277	181	15	changes	change	NOUN
aiua-13277	181	16	in	in	ADP
aiua-13277	181	17	melamine	melamine	ADJ
aiua-13277	181	18	-	-	PUNCT
aiua-13277	181	19	uric	uric	ADJ
aiua-13277	181	20	acid	acid	NOUN
aiua-13277	181	21	clusters	cluster	NOUN
aiua-13277	181	22	responsible	responsible	ADJ
aiua-13277	181	23	for	for	ADP
aiua-13277	181	24	kidney	kidney	NOUN
aiua-13277	181	25	stones	stone	NOUN
aiua-13277	181	26	.	.	PUNCT
aiua-13277	182	1	j	j	PROPN
aiua-13277	182	2	phys	phys	PROPN
aiua-13277	182	3	chem	chem	PROPN
aiua-13277	182	4	b.	b.	PROPN
aiua-13277	182	5	2019	2019	NUM
aiua-13277	182	6	;	;	PUNCT
aiua-13277	182	7	123:10483	123:10483	NUM
aiua-13277	182	8	-	-	SYM
aiua-13277	182	9	10504	10504	NUM
aiua-13277	182	10	.	.	PUNCT
aiua-13277	183	1	27	27	NUM
aiua-13277	183	2	.	.	PUNCT
aiua-13277	184	1	sadi	sadi	PROPN
aiua-13277	184	2	mv	mv	PROPN
aiua-13277	184	3	,	,	PUNCT
aiua-13277	184	4	saltzman	saltzman	PROPN
aiua-13277	184	5	n	n	PROPN
aiua-13277	184	6	,	,	PUNCT
aiua-13277	184	7	feria	feria	PROPN
aiua-13277	184	8	g	g	PROPN
aiua-13277	184	9	,	,	PUNCT
aiua-13277	184	10	gittes	gitte	NOUN
aiua-13277	184	11	rf	rf	VERB
aiua-13277	184	12	.	.	PUNCT
aiua-13277	184	13	experimental	experimental	ADJ
aiua-13277	184	14	observations	observation	NOUN
aiua-13277	184	15	on	on	ADP
aiua-13277	184	16	dissolution	dissolution	NOUN
aiua-13277	184	17	of	of	ADP
aiua-13277	184	18	uric	uric	ADJ
aiua-13277	184	19	acid	acid	ADJ
aiua-13277	184	20	calculi	calculi	PROPN
aiua-13277	184	21	.	.	PUNCT
aiua-13277	185	1	j	j	PROPN
aiua-13277	185	2	urol	urol	PROPN
aiua-13277	185	3	.	.	PUNCT
aiua-13277	186	1	1985	1985	NUM
aiua-13277	186	2	;	;	PUNCT
aiua-13277	186	3	134:575	134:575	NUM
aiua-13277	186	4	-	-	SYM
aiua-13277	186	5	579	579	NUM
aiua-13277	186	6	.	.	PUNCT
aiua-13277	187	1	28	28	NUM
aiua-13277	187	2	.	.	PUNCT
aiua-13277	188	1	grases	grase	NOUN
aiua-13277	188	2	f	f	PROPN
aiua-13277	188	3	,	,	PUNCT
aiua-13277	188	4	et	et	PROPN
aiua-13277	188	5	al	al	PROPN
aiua-13277	188	6	.	.	PROPN
aiua-13277	188	7	combination	combination	NOUN
aiua-13277	188	8	of	of	ADP
aiua-13277	188	9	a	a	DET
aiua-13277	188	10	urinary	urinary	ADJ
aiua-13277	188	11	basifying	basifying	NOUN
aiua-13277	188	12	agent	agent	NOUN
aiua-13277	188	13	and	and	CCONJ
aiua-13277	188	14	an	an	DET
aiua-13277	188	15	uric	uric	ADJ
aiua-13277	188	16	acid	acid	NOUN
aiua-13277	188	17	crystallisation	crystallisation	NOUN
aiua-13277	188	18	inhibitor	inhibitor	NOUN
aiua-13277	188	19	for	for	ADP
aiua-13277	188	20	the	the	DET
aiua-13277	188	21	treatment	treatment	NOUN
aiua-13277	188	22	and	and	CCONJ
aiua-13277	188	23	prevention	prevention	NOUN
aiua-13277	188	24	of	of	ADP
aiua-13277	188	25	renal	renal	ADJ
aiua-13277	188	26	lithiasis	lithiasis	NOUN
aiua-13277	188	27	.	.	PUNCT
aiua-13277	189	1	ep3130337b1	ep3130337b1	NOUN
aiua-13277	189	2	,	,	PUNCT
aiua-13277	189	3	2019	2019	NUM
aiua-13277	189	4	.	.	PUNCT
aiua-13277	190	1	29	29	NUM
aiua-13277	190	2	.	.	PUNCT
aiua-13277	191	1	grases	grase	NOUN
aiua-13277	191	2	f	f	PROPN
aiua-13277	191	3	,	,	PUNCT
aiua-13277	191	4	et	et	PROPN
aiua-13277	191	5	al	al	PROPN
aiua-13277	191	6	.	.	PROPN
aiua-13277	191	7	theobromine	theobromine	NOUN
aiua-13277	191	8	or	or	CCONJ
aiua-13277	191	9	its	its	PRON
aiua-13277	191	10	derivatives	derivative	NOUN
aiua-13277	191	11	for	for	ADP
aiua-13277	191	12	the	the	DET
aiua-13277	191	13	treatment	treatment	NOUN
aiua-13277	191	14	or	or	CCONJ
aiua-13277	191	15	prevention	prevention	NOUN
aiua-13277	191	16	of	of	ADP
aiua-13277	191	17	uric	uric	ADJ
aiua-13277	191	18	acid	acid	ADJ
aiua-13277	191	19	renal	renal	ADJ
aiua-13277	191	20	lithiasis	lithiasis	NOUN
aiua-13277	191	21	.	.	PUNCT
aiua-13277	192	1	ep3150208b1	ep3150208b1	ADV
aiua-13277	192	2	,	,	PUNCT
aiua-13277	192	3	2023	2023	NUM
aiua-13277	192	4	.	.	PUNCT
aiua-13277	193	1	30	30	NUM
aiua-13277	193	2	.	.	PUNCT
aiua-13277	194	1	hernandez	hernandez	PROPN
aiua-13277	194	2	y	y	PROPN
aiua-13277	194	3	,	,	PUNCT
aiua-13277	194	4	costa	costa	NOUN
aiua-13277	194	5	-	-	PUNCT
aiua-13277	194	6	bauza	bauza	NOUN
aiua-13277	194	7	a	a	NOUN
aiua-13277	194	8	,	,	PUNCT
aiua-13277	194	9	calvó	calvó	NOUN
aiua-13277	194	10	p	p	PROPN
aiua-13277	194	11	,	,	PUNCT
aiua-13277	194	12	et	et	PROPN
aiua-13277	194	13	al	al	PROPN
aiua-13277	194	14	.	.	PROPN
aiua-13277	194	15	comparison	comparison	NOUN
aiua-13277	194	16	of	of	ADP
aiua-13277	194	17	two	two	NUM
aiua-13277	194	18	dietary	dietary	ADJ
aiua-13277	194	19	supplements	supplement	NOUN
aiua-13277	194	20	for	for	ADP
aiua-13277	194	21	treatment	treatment	NOUN
aiua-13277	194	22	of	of	ADP
aiua-13277	194	23	uric	uric	ADJ
aiua-13277	194	24	acid	acid	ADJ
aiua-13277	194	25	renal	renal	ADJ
aiua-13277	194	26	lithiasis	lithiasis	NOUN
aiua-13277	194	27	:	:	PUNCT
aiua-13277	194	28	citrate	citrate	NOUN
aiua-13277	194	29	vs	vs	ADP
aiua-13277	194	30	citrate	citrate	NOUN
aiua-13277	194	31	+	+	CCONJ
aiua-13277	194	32	theobromine	theobromine	NOUN
aiua-13277	194	33	.	.	PUNCT
aiua-13277	195	1	nutr	nutr	PROPN
aiua-13277	195	2	.	.	PROPN
aiua-13277	195	3	2020	2020	NUM
aiua-13277	195	4	;	;	PUNCT
aiua-13277	196	1	12:2012	12:2012	X
aiua-13277	196	2	.	.	NOUN
aiua-13277	196	3	31	31	NUM
aiua-13277	196	4	.	.	PUNCT
aiua-13277	197	1	carpenter	carpenter	NOUN
aiua-13277	197	2	to	to	ADP
aiua-13277	197	3	,	,	PUNCT
aiua-13277	197	4	lebowitz	lebowitz	PROPN
aiua-13277	197	5	rl	rl	PROPN
aiua-13277	197	6	,	,	PUNCT
aiua-13277	197	7	nelson	nelson	PROPN
aiua-13277	197	8	d	d	PROPN
aiua-13277	197	9	,	,	PUNCT
aiua-13277	197	10	bauer	bauer	PROPN
aiua-13277	197	11	s.	s.	PROPN
aiua-13277	197	12	hereditary	hereditary	PROPN
aiua-13277	197	13	xanthinuria	xanthinuria	PROPN
aiua-13277	197	14	presenting	present	VERB
aiua-13277	197	15	in	in	ADP
aiua-13277	197	16	infancy	infancy	PROPN
aiua-13277	197	17	nephrolithiasis	nephrolithiasis	NOUN
aiua-13277	197	18	.	.	PUNCT
aiua-13277	198	1	j	j	PROPN
aiua-13277	198	2	pediatr	pediatr	PROPN
aiua-13277	198	3	.	.	PUNCT
aiua-13277	199	1	1986	1986	NUM
aiua-13277	199	2	;	;	PUNCT
aiua-13277	199	3	109:307	109:307	NUM
aiua-13277	199	4	-	-	SYM
aiua-13277	199	5	309	309	NUM
aiua-13277	199	6	.	.	PUNCT
aiua-13277	200	1	32	32	NUM
aiua-13277	200	2	.	.	PUNCT
aiua-13277	200	3	mateos	mateos	PROPN
aiua-13277	200	4	fa	fa	PROPN
aiua-13277	200	5	,	,	PUNCT
aiua-13277	200	6	puig	puig	VERB
aiua-13277	200	7	jg	jg	PROPN
aiua-13277	200	8	,	,	PUNCT
aiua-13277	200	9	jimenez	jimenez	PROPN
aiua-13277	200	10	ml	ml	PROPN
aiua-13277	200	11	,	,	PUNCT
aiua-13277	200	12	fox	fox	PROPN
aiua-13277	200	13	ih	ih	PRON
aiua-13277	200	14	.	.	PUNCT
aiua-13277	201	1	hereditary	hereditary	ADJ
aiua-13277	201	2	xanthinuria	xanthinuria	NOUN
aiua-13277	201	3	:	:	PUNCT
aiua-13277	201	4	evidence	evidence	NOUN
aiua-13277	201	5	for	for	ADP
aiua-13277	201	6	enhanced	enhanced	ADJ
aiua-13277	201	7	hypoxanthine	hypoxanthine	NOUN
aiua-13277	201	8	salvage	salvage	NOUN
aiua-13277	201	9	.	.	PUNCT
aiua-13277	202	1	j	j	PROPN
aiua-13277	202	2	clin	clin	PROPN
aiua-13277	202	3	invest	invest	PROPN
aiua-13277	202	4	.	.	PUNCT
aiua-13277	203	1	1987	1987	NUM
aiua-13277	203	2	;	;	PUNCT
aiua-13277	204	1	79:847	79:847	X
aiua-13277	204	2	-	-	SYM
aiua-13277	204	3	852	852	NUM
aiua-13277	204	4	.	.	PUNCT
aiua-13277	205	1	33	33	NUM
aiua-13277	205	2	.	.	PUNCT
aiua-13277	206	1	ichida	ichida	PROPN
aiua-13277	206	2	k	k	PROPN
aiua-13277	206	3	,	,	PUNCT
aiua-13277	206	4	amaya	amaya	PROPN
aiua-13277	206	5	y	y	PROPN
aiua-13277	206	6	,	,	PUNCT
aiua-13277	206	7	okamoto	okamoto	PROPN
aiua-13277	206	8	k	k	PROPN
aiua-13277	206	9	,	,	PUNCT
aiua-13277	206	10	nishino	nishino	PROPN
aiua-13277	206	11	t.	t.	NOUN
aiua-13277	206	12	mutations	mutation	NOUN
aiua-13277	206	13	associated	associate	VERB
aiua-13277	206	14	with	with	ADP
aiua-13277	206	15	functional	functional	ADJ
aiua-13277	206	16	disorder	disorder	NOUN
aiua-13277	206	17	of	of	ADP
aiua-13277	206	18	xanthine	xanthine	NOUN
aiua-13277	206	19	oxidoreductase	oxidoreductase	NOUN
aiua-13277	206	20	and	and	CCONJ
aiua-13277	206	21	hereditary	hereditary	ADJ
aiua-13277	206	22	xanthinuria	xanthinuria	NOUN
aiua-13277	206	23	in	in	ADP
aiua-13277	206	24	humans	human	NOUN
aiua-13277	206	25	.	.	PUNCT
aiua-13277	207	1	int	int	PROPN
aiua-13277	207	2	j	j	PROPN
aiua-13277	207	3	mol	mol	ADP
aiua-13277	207	4	sci	sci	PROPN
aiua-13277	207	5	.	.	PROPN
aiua-13277	207	6	2012	2012	NUM
aiua-13277	207	7	;	;	PUNCT
aiua-13277	207	8	13:15475	13:15475	NUM
aiua-13277	207	9	-	-	SYM
aiua-13277	207	10	15495	15495	NUM
aiua-13277	207	11	.	.	PUNCT
aiua-13277	208	1	34	34	NUM
aiua-13277	208	2	.	.	PUNCT
aiua-13277	209	1	ichida	ichida	PROPN
aiua-13277	209	2	k	k	PROPN
aiua-13277	209	3	,	,	PUNCT
aiua-13277	209	4	matsumura	matsumura	PROPN
aiua-13277	209	5	t	t	PROPN
aiua-13277	209	6	,	,	PUNCT
aiua-13277	209	7	sakuma	sakuma	PROPN
aiua-13277	209	8	r	r	PROPN
aiua-13277	209	9	,	,	PUNCT
aiua-13277	209	10	et	et	PROPN
aiua-13277	209	11	al	al	PROPN
aiua-13277	209	12	.	.	PROPN
aiua-13277	210	1	mutation	mutation	NOUN
aiua-13277	210	2	of	of	ADP
aiua-13277	210	3	human	human	ADJ
aiua-13277	210	4	molybdenum	molybdenum	NOUN
aiua-13277	210	5	cofactor	cofactor	NOUN
aiua-13277	210	6	sulfurase	sulfurase	NOUN
aiua-13277	210	7	gene	gene	NOUN
aiua-13277	210	8	is	be	AUX
aiua-13277	210	9	responsible	responsible	ADJ
aiua-13277	210	10	for	for	ADP
aiua-13277	210	11	classical	classical	ADJ
aiua-13277	210	12	xanthinuria	xanthinuria	NOUN
aiua-13277	210	13	type	type	PROPN
aiua-13277	210	14	ii	ii	PROPN
aiua-13277	210	15	.	.	PUNCT
aiua-13277	211	1	biochem	biochem	PROPN
aiua-13277	211	2	biophys	biophys	PROPN
aiua-13277	211	3	res	re	NOUN
aiua-13277	211	4	commun	commun	PROPN
aiua-13277	211	5	.	.	PUNCT
aiua-13277	212	1	2001	2001	NUM
aiua-13277	212	2	;	;	PUNCT
aiua-13277	212	3	282:1194	282:1194	X
aiua-13277	212	4	-	-	SYM
aiua-13277	212	5	1200	1200	NUM
aiua-13277	212	6	.	.	PUNCT
aiua-13277	213	1	35	35	NUM
aiua-13277	213	2	.	.	PUNCT
aiua-13277	214	1	mraz	mraz	PROPN
aiua-13277	214	2	m	m	PROPN
aiua-13277	214	3	,	,	PUNCT
aiua-13277	214	4	hurba	hurba	ADJ
aiua-13277	214	5	o	o	NOUN
aiua-13277	214	6	,	,	PUNCT
aiua-13277	214	7	bartl	bartl	PROPN
aiua-13277	214	8	j	j	PROPN
aiua-13277	214	9	,	,	PUNCT
aiua-13277	214	10	et	et	PROPN
aiua-13277	214	11	al	al	PROPN
aiua-13277	214	12	.	.	PUNCT
aiua-13277	215	1	modern	modern	ADJ
aiua-13277	215	2	diagnostic	diagnostic	ADJ
aiua-13277	215	3	approach	approach	NOUN
aiua-13277	215	4	to	to	ADP
aiua-13277	215	5	hereditary	hereditary	ADJ
aiua-13277	215	6	xanthinuria	xanthinuria	NOUN
aiua-13277	215	7	.	.	PUNCT
aiua-13277	216	1	urolithiasis	urolithiasis	NOUN
aiua-13277	216	2	.	.	PUNCT
aiua-13277	217	1	2015	2015	NUM
aiua-13277	217	2	;	;	PUNCT
aiua-13277	217	3	43:61	43:61	NUM
aiua-13277	217	4	-	-	SYM
aiua-13277	217	5	67	67	NUM
aiua-13277	217	6	.	.	PUNCT
aiua-13277	218	1	36	36	NUM
aiua-13277	218	2	.	.	PUNCT
aiua-13277	219	1	grases	grase	NOUN
aiua-13277	219	2	f	f	PROPN
aiua-13277	219	3	,	,	PUNCT
aiua-13277	219	4	costa	costa	NOUN
aiua-13277	219	5	-	-	PUNCT
aiua-13277	219	6	bauza	bauza	NOUN
aiua-13277	219	7	a	a	NOUN
aiua-13277	219	8	,	,	PUNCT
aiua-13277	219	9	roig	roig	PROPN
aiua-13277	219	10	j	j	PROPN
aiua-13277	219	11	,	,	PUNCT
aiua-13277	219	12	rodriguez	rodriguez	PROPN
aiua-13277	219	13	a.	a.	PROPN
aiua-13277	219	14	xanthine	xanthine	PROPN
aiua-13277	219	15	urolithiasis	urolithiasis	VERB
aiua-13277	219	16	:	:	PUNCT
aiua-13277	219	17	inhibitors	inhibitor	NOUN
aiua-13277	219	18	of	of	ADP
aiua-13277	219	19	xanthine	xanthine	NOUN
aiua-13277	219	20	crystallization	crystallization	NOUN
aiua-13277	219	21	.	.	PUNCT
aiua-13277	220	1	plos	plos	PROPN
aiua-13277	220	2	one	one	NUM
aiua-13277	220	3	.	.	PUNCT
aiua-13277	220	4	2018	2018	NUM
aiua-13277	220	5	;	;	PUNCT
aiua-13277	220	6	13	13	NUM
aiua-13277	220	7	:	:	PUNCT
aiua-13277	220	8	e0198881	e0198881	NUM
aiua-13277	220	9	.	.	PUNCT
aiua-13277	221	1	37	37	NUM
aiua-13277	221	2	.	.	PUNCT
aiua-13277	222	1	archer	archer	PROPN
aiua-13277	222	2	he	he	PRON
aiua-13277	222	3	,	,	PUNCT
aiua-13277	222	4	rhoden	rhoden	PROPN
aiua-13277	222	5	e.	e.	PROPN
aiua-13277	222	6	uric	uric	ADJ
aiua-13277	222	7	-	-	PUNCT
aiua-13277	222	8	acid	acid	ADJ
aiua-13277	222	9	levels	level	NOUN
aiua-13277	222	10	in	in	ADP
aiua-13277	222	11	blood	blood	NOUN
aiua-13277	222	12	and	and	CCONJ
aiua-13277	222	13	plasma	plasma	NOUN
aiua-13277	222	14	.	.	PUNCT
aiua-13277	223	1	br	br	PROPN
aiua-13277	223	2	med	med	PROPN
aiua-13277	223	3	j.	j.	PROPN
aiua-13277	223	4	1951	1951	NUM
aiua-13277	223	5	;	;	PUNCT
aiua-13277	223	6	2:947	2:947	NUM
aiua-13277	223	7	.	.	PUNCT
aiua-13277	224	1	38	38	NUM
aiua-13277	224	2	.	.	PUNCT
aiua-13277	225	1	kippen	kippen	PROPN
aiua-13277	225	2	i	i	PRON
aiua-13277	225	3	,	,	PUNCT
aiua-13277	225	4	klinenberg	klinenberg	PROPN
aiua-13277	225	5	jr	jr	PROPN
aiua-13277	225	6	,	,	PUNCT
aiua-13277	225	7	weinberger	weinberger	PROPN
aiua-13277	225	8	a	a	PROPN
aiua-13277	225	9	,	,	PUNCT
aiua-13277	225	10	wilcox	wilcox	PROPN
aiua-13277	225	11	wr	wr	PROPN
aiua-13277	225	12	.	.	PUNCT
aiua-13277	226	1	factors	factor	NOUN
aiua-13277	226	2	affecting	affect	VERB
aiua-13277	226	3	urate	urate	NOUN
aiua-13277	226	4	solubility	solubility	NOUN
aiua-13277	226	5	in	in	ADP
aiua-13277	226	6	vitro	vitro	X
aiua-13277	226	7	.	.	PUNCT
aiua-13277	227	1	ann	ann	PROPN
aiua-13277	227	2	rheum	rheum	PROPN
aiua-13277	227	3	dis	dis	PROPN
aiua-13277	227	4	.	.	PUNCT
aiua-13277	228	1	1974	1974	NUM
aiua-13277	228	2	;	;	PUNCT
aiua-13277	228	3	33:313	33:313	NUM
aiua-13277	228	4	-	-	SYM
aiua-13277	228	5	317	317	NUM
aiua-13277	228	6	.	.	NUM
aiua-13277	228	7	39	39	NUM
aiua-13277	228	8	.	.	PUNCT
aiua-13277	229	1	liu	liu	PROPN
aiua-13277	229	2	y	y	PROPN
aiua-13277	229	3	,	,	PUNCT
aiua-13277	229	4	zhang	zhang	PROPN
aiua-13277	229	5	q	q	PROPN
aiua-13277	229	6	,	,	PUNCT
aiua-13277	229	7	du	du	PROPN
aiua-13277	229	8	j	j	PROPN
aiua-13277	229	9	,	,	PUNCT
aiua-13277	229	10	guo	guo	PROPN
aiua-13277	229	11	r.	r.	PROPN
aiua-13277	229	12	arginine	arginine	PROPN
aiua-13277	229	13	-	-	PUNCT
aiua-13277	229	14	rich	rich	ADJ
aiua-13277	229	15	peptides	peptide	NOUN
aiua-13277	229	16	as	as	ADP
aiua-13277	229	17	crystallization	crystallization	NOUN
aiua-13277	229	18	inhibitors	inhibitor	NOUN
aiua-13277	229	19	for	for	ADP
aiua-13277	229	20	sodium	sodium	NOUN
aiua-13277	229	21	urate	urate	NOUN
aiua-13277	229	22	.	.	PUNCT
aiua-13277	230	1	j	j	PROPN
aiua-13277	230	2	mater	mater	PROPN
aiua-13277	230	3	chem	chem	PROPN
aiua-13277	230	4	b.	b.	PROPN
aiua-13277	230	5	2023	2023	NUM
aiua-13277	230	6	;	;	PUNCT
aiua-13277	231	1	11:73897400	11:73897400	NUM
aiua-13277	231	2	.	.	NOUN
aiua-13277	231	3	40	40	NUM
aiua-13277	231	4	.	.	PUNCT
aiua-13277	232	1	liu	liu	PROPN
aiua-13277	232	2	y	y	PROPN
aiua-13277	232	3	,	,	PUNCT
aiua-13277	232	4	zhang	zhang	PROPN
aiua-13277	232	5	q	q	PROPN
aiua-13277	232	6	,	,	PUNCT
aiua-13277	232	7	li	li	PROPN
aiua-13277	232	8	n	n	PROPN
aiua-13277	232	9	,	,	PUNCT
aiua-13277	232	10	et	et	PROPN
aiua-13277	232	11	al	al	PROPN
aiua-13277	232	12	.	.	PROPN
aiua-13277	233	1	efficient	efficient	ADJ
aiua-13277	233	2	synergistic	synergistic	ADJ
aiua-13277	233	3	cooperation	cooperation	NOUN
aiua-13277	233	4	of	of	ADP
aiua-13277	233	5	an	an	DET
aiua-13277	233	6	arginine	arginine	NOUN
aiua-13277	233	7	-	-	PUNCT
aiua-13277	233	8	rich	rich	ADJ
aiua-13277	233	9	peptide	peptide	NOUN
aiua-13277	233	10	and	and	CCONJ
aiua-13277	233	11	copper	copper	NOUN
aiua-13277	233	12	ions	ion	NOUN
aiua-13277	233	13	in	in	ADP
aiua-13277	233	14	sodium	sodium	NOUN
aiua-13277	233	15	urate	urate	NOUN
aiua-13277	233	16	crystallization	crystallization	NOUN
aiua-13277	233	17	inhibition	inhibition	NOUN
aiua-13277	233	18	.	.	PUNCT
aiua-13277	234	1	langmuir	langmuir	PROPN
aiua-13277	234	2	.	.	PUNCT
aiua-13277	235	1	2023	2023	NUM
aiua-13277	235	2	;	;	PUNCT
aiua-13277	235	3	39:9942	39:9942	NUM
aiua-13277	235	4	-	-	SYM
aiua-13277	235	5	9951	9951	NUM
aiua-13277	235	6	.	.	PUNCT
aiua-13277	236	1	41	41	NUM
aiua-13277	236	2	.	.	PUNCT
aiua-13277	236	3	hall	hall	PROPN
aiua-13277	236	4	vm	vm	PROPN
aiua-13277	236	5	,	,	PUNCT
aiua-13277	236	6	thornton	thornton	PROPN
aiua-13277	236	7	a	a	PROPN
aiua-13277	236	8	,	,	PUNCT
aiua-13277	236	9	miehls	miehls	PROPN
aiua-13277	236	10	ek	ek	PROPN
aiua-13277	236	11	,	,	PUNCT
aiua-13277	236	12	et	et	PROPN
aiua-13277	236	13	al	al	PROPN
aiua-13277	236	14	.	.	PROPN
aiua-13277	236	15	uric	uric	ADJ
aiua-13277	236	16	acid	acid	NOUN
aiua-13277	236	17	crystallization	crystallization	NOUN
aiua-13277	236	18	interrupted	interrupt	VERB
aiua-13277	236	19	with	with	ADP
aiua-13277	236	20	competing	compete	VERB
aiua-13277	236	21	binding	bind	VERB
aiua-13277	236	22	agents	agent	NOUN
aiua-13277	236	23	.	.	PUNCT
aiua-13277	237	1	cryst	cryst	PROPN
aiua-13277	237	2	.	.	PUNCT
aiua-13277	238	1	growth	growth	PROPN
aiua-13277	238	2	des	des	PROPN
aiua-13277	238	3	.	.	PROPN
aiua-13277	238	4	2019	2019	NUM
aiua-13277	238	5	;	;	PUNCT
aiua-13277	238	6	19:7363	19:7363	NUM
aiua-13277	238	7	-	-	SYM
aiua-13277	238	8	7371	7371	NUM
aiua-13277	238	9	.	.	PUNCT
aiua-13277	239	1	42	42	NUM
aiua-13277	239	2	.	.	PUNCT
aiua-13277	240	1	chattaraj	chattaraj	PROPN
aiua-13277	240	2	kg	kg	PROPN
aiua-13277	240	3	,	,	PUNCT
aiua-13277	240	4	paul	paul	PROPN
aiua-13277	240	5	s.	s.	PROPN
aiua-13277	240	6	appraising	appraise	VERB
aiua-13277	240	7	the	the	DET
aiua-13277	240	8	potency	potency	NOUN
aiua-13277	240	9	of	of	ADP
aiua-13277	240	10	small	small	ADJ
aiua-13277	240	11	molecule	molecule	NOUN
aiua-13277	240	12	inhibitors	inhibitor	NOUN
aiua-13277	240	13	and	and	CCONJ
aiua-13277	240	14	their	their	PRON
aiua-13277	240	15	graphene	graphene	ADJ
aiua-13277	240	16	surface	surface	NOUN
aiua-13277	240	17	-	-	PUNCT
aiua-13277	240	18	mediated	mediate	VERB
aiua-13277	240	19	organizational	organizational	ADJ
aiua-13277	240	20	attributes	attribute	NOUN
aiua-13277	240	21	on	on	ADP
aiua-13277	240	22	uric	uric	ADJ
aiua-13277	240	23	acid	acid	NOUN
aiua-13277	240	24	-	-	PUNCT
aiua-13277	240	25	melamine	melamine	NOUN
aiua-13277	240	26	clusters	cluster	NOUN
aiua-13277	240	27	.	.	PUNCT
aiua-13277	241	1	phys	phy	NOUN
aiua-13277	241	2	chem	chem	NOUN
aiua-13277	241	3	phys	phy	NOUN
aiua-13277	241	4	.	.	PUNCT
aiua-13277	242	1	2022	2022	NUM
aiua-13277	242	2	;	;	PUNCT
aiua-13277	242	3	24:1029	24:1029	NUM
aiua-13277	242	4	-	-	SYM
aiua-13277	242	5	104	104	NUM
aiua-13277	242	6	.	.	PUNCT
aiua-13277	243	1	43	43	NUM
aiua-13277	243	2	.	.	PUNCT
aiua-13277	244	1	chattaraj	chattaraj	PROPN
aiua-13277	244	2	kg	kg	PROPN
aiua-13277	244	3	,	,	PUNCT
aiua-13277	244	4	paul	paul	PROPN
aiua-13277	244	5	s.	s.	PROPN
aiua-13277	244	6	the	the	DET
aiua-13277	244	7	miscibility	miscibility	NOUN
aiua-13277	244	8	and	and	CCONJ
aiua-13277	244	9	solubility	solubility	NOUN
aiua-13277	244	10	of	of	ADP
aiua-13277	244	11	uric	uric	ADJ
aiua-13277	244	12	acid	acid	NOUN
aiua-13277	244	13	and	and	CCONJ
aiua-13277	244	14	vitamin	vitamin	NOUN
aiua-13277	244	15	c	c	NOUN
aiua-13277	244	16	in	in	ADP
aiua-13277	244	17	the	the	DET
aiua-13277	244	18	solution	solution	NOUN
aiua-13277	244	19	phase	phase	NOUN
aiua-13277	244	20	and	and	CCONJ
aiua-13277	244	21	their	their	PRON
aiua-13277	244	22	structural	structural	ADJ
aiua-13277	244	23	alignment	alignment	NOUN
aiua-13277	244	24	in	in	ADP
aiua-13277	244	25	the	the	DET
aiua-13277	244	26	solid	solid	ADJ
aiua-13277	244	27	-	-	PUNCT
aiua-13277	244	28	liquid	liquid	ADJ
aiua-13277	244	29	interface	interface	NOUN
aiua-13277	244	30	.	.	PUNCT
aiua-13277	245	1	phys	phy	NOUN
aiua-13277	245	2	chem	chem	VERB
aiua-13277	245	3	chem	chem	NOUN
aiua-13277	245	4	phys	phy	NOUN
aiua-13277	245	5	.	.	PUNCT
aiua-13277	246	1	2021	2021	NUM
aiua-13277	246	2	;	;	PUNCT
aiua-13277	246	3	23:1516915182	23:1516915182	X
aiua-13277	246	4	.	.	NOUN
aiua-13277	246	5	44	44	NUM
aiua-13277	246	6	.	.	PUNCT
aiua-13277	247	1	choi	choi	PROPN
aiua-13277	247	2	hk	hk	PROPN
aiua-13277	247	3	,	,	PUNCT
aiua-13277	247	4	curhan	curhan	PROPN
aiua-13277	247	5	g.	g.	PROPN
aiua-13277	247	6	coffee	coffee	NOUN
aiua-13277	247	7	consumption	consumption	NOUN
aiua-13277	247	8	and	and	CCONJ
aiua-13277	247	9	risk	risk	NOUN
aiua-13277	247	10	of	of	ADP
aiua-13277	247	11	incident	incident	NOUN
aiua-13277	247	12	gout	gout	NOUN
aiua-13277	247	13	in	in	ADP
aiua-13277	247	14	women	woman	NOUN
aiua-13277	247	15	:	:	PUNCT
aiua-13277	247	16	the	the	DET
aiua-13277	247	17	nurses	nurse	NOUN
aiua-13277	247	18	’	'	PUNCT
aiua-13277	247	19	health	health	NOUN
aiua-13277	247	20	study	study	NOUN
aiua-13277	247	21	.	.	PUNCT
aiua-13277	248	1	am	be	AUX
aiua-13277	248	2	j	j	PROPN
aiua-13277	248	3	clin	clin	PROPN
aiua-13277	248	4	nutr	nutr	PROPN
aiua-13277	248	5	.	.	PROPN
aiua-13277	248	6	2010	2010	NUM
aiua-13277	248	7	;	;	PUNCT
aiua-13277	248	8	92:922	92:922	NUM
aiua-13277	248	9	-	-	SYM
aiua-13277	248	10	927	927	NUM
aiua-13277	248	11	.	.	PUNCT
aiua-13277	249	1	45	45	NUM
aiua-13277	249	2	.	.	PUNCT
aiua-13277	250	1	dillinger	dillinger	PROPN
aiua-13277	250	2	tl	tl	PROPN
aiua-13277	250	3	,	,	PUNCT
aiua-13277	250	4	barriga	barriga	PROPN
aiua-13277	250	5	p	p	PROPN
aiua-13277	250	6	,	,	PUNCT
aiua-13277	250	7	escárcega	escárcega	NOUN
aiua-13277	250	8	s	s	PROPN
aiua-13277	250	9	,	,	PUNCT
aiua-13277	250	10	et	et	PROPN
aiua-13277	250	11	al	al	PROPN
aiua-13277	250	12	.	.	PUNCT
aiua-13277	250	13	food	food	NOUN
aiua-13277	250	14	of	of	ADP
aiua-13277	250	15	the	the	DET
aiua-13277	250	16	gods	god	NOUN
aiua-13277	250	17	:	:	PUNCT
aiua-13277	250	18	cure	cure	NOUN
aiua-13277	250	19	for	for	ADP
aiua-13277	250	20	humanity	humanity	NOUN
aiua-13277	250	21	?	?	PUNCT
aiua-13277	251	1	a	a	DET
aiua-13277	251	2	cultural	cultural	ADJ
aiua-13277	251	3	history	history	NOUN
aiua-13277	251	4	of	of	ADP
aiua-13277	251	5	the	the	DET
aiua-13277	251	6	medicinal	medicinal	ADJ
aiua-13277	251	7	and	and	CCONJ
aiua-13277	251	8	ritual	ritual	ADJ
aiua-13277	251	9	use	use	NOUN
aiua-13277	251	10	of	of	ADP
aiua-13277	251	11	chocolate	chocolate	NOUN
aiua-13277	251	12	.	.	PUNCT
aiua-13277	252	1	j	j	PROPN
aiua-13277	252	2	nutr	nutr	PROPN
aiua-13277	252	3	.	.	PROPN
aiua-13277	252	4	2000	2000	NUM
aiua-13277	252	5	;	;	PUNCT
aiua-13277	252	6	130(suppl	130(suppl	NOUN
aiua-13277	252	7	.	.	PUNCT
aiua-13277	253	1	s8):2057s-2072s	s8):2057s-2072s	PROPN
aiua-13277	253	2	.	.	PUNCT
aiua-13277	254	1	46	46	NUM
aiua-13277	254	2	.	.	PUNCT
aiua-13277	255	1	costa	costa	NOUN
aiua-13277	255	2	-	-	PUNCT
aiua-13277	255	3	bauza	bauza	NOUN
aiua-13277	255	4	a	a	NOUN
aiua-13277	255	5	,	,	PUNCT
aiua-13277	255	6	grases	grase	NOUN
aiua-13277	255	7	f.	f.	PROPN
aiua-13277	255	8	7	7	NUM
aiua-13277	255	9	-	-	PUNCT
aiua-13277	255	10	methylxanthine	methylxanthine	NOUN
aiua-13277	255	11	inhibits	inhibit	VERB
aiua-13277	255	12	the	the	DET
aiua-13277	255	13	formation	formation	NOUN
aiua-13277	255	14	of	of	ADP
aiua-13277	255	15	monosodium	monosodium	NOUN
aiua-13277	255	16	urate	urate	NOUN
aiua-13277	255	17	crystals	crystal	NOUN
aiua-13277	255	18	by	by	ADP
aiua-13277	255	19	increasing	increase	VERB
aiua-13277	255	20	its	its	PRON
aiua-13277	255	21	solubility	solubility	NOUN
aiua-13277	255	22	.	.	PUNCT
aiua-13277	256	1	biomolecules	biomolecule	NOUN
aiua-13277	256	2	.	.	PUNCT
aiua-13277	257	1	2023	2023	NUM
aiua-13277	257	2	;	;	PUNCT
aiua-13277	257	3	13:1769	13:1769	NUM
aiua-13277	257	4	.	.	PUNCT
aiua-13277	258	1	correspondence	correspondence	NOUN
aiua-13277	258	2	alberto	alberto	PROPN
aiua-13277	258	3	trinchieri	trinchieri	PROPN
aiua-13277	258	4	,	,	PUNCT
aiua-13277	258	5	md	md	PROPN
aiua-13277	258	6	(	(	PUNCT
aiua-13277	258	7	corresponding	correspond	VERB
aiua-13277	258	8	author	author	NOUN
aiua-13277	258	9	)	)	PUNCT
aiua-13277	258	10	alberto.trinchieri@gmail.com	alberto.trinchieri@gmail.com	X
aiua-13277	258	11	c.d.c	c.d.c	PROPN
aiua-13277	258	12	.	.	PUNCT
aiua-13277	258	13	ambrosiana	ambrosiana	PROPN
aiua-13277	258	14	,	,	PUNCT
aiua-13277	258	15	cesano	cesano	PROPN
aiua-13277	258	16	boscone	boscone	PROPN
aiua-13277	258	17	,	,	PUNCT
aiua-13277	258	18	milan	milan	PROPN
aiua-13277	258	19	,	,	PUNCT
aiua-13277	258	20	italy	italy	PROPN
aiua-13277	258	21	conflict	conflict	NOUN
aiua-13277	258	22	of	of	ADP
aiua-13277	258	23	interest	interest	NOUN
aiua-13277	259	1	:	:	PUNCT
aiua-13277	259	2	the	the	DET
aiua-13277	259	3	authors	author	NOUN
aiua-13277	259	4	declare	declare	VERB
aiua-13277	259	5	no	no	DET
aiua-13277	259	6	potential	potential	ADJ
aiua-13277	259	7	conflict	conflict	NOUN
aiua-13277	259	8	of	of	ADP
aiua-13277	259	9	interest	interest	NOUN
aiua-13277	259	10	.	.	PUNCT