id	sid	tid	token	lemma	pos
aiua-13318	1	1	stesura	stesura	PROPN
aiua-13318	1	2	seveso	seveso	PROPN
aiua-13318	1	3	archivio	archivio	PROPN
aiua-13318	1	4	italiano	italiano	X
aiua-13318	1	5	di	di	X
aiua-13318	1	6	urologia	urologia	PROPN
aiua-13318	1	7	e	e	PROPN
aiua-13318	1	8	andrologia	andrologia	NOUN
aiua-13318	1	9	2025	2025	NUM
aiua-13318	1	10	;	;	PUNCT
aiua-13318	1	11	97(1):13318	97(1):13318	NUM
aiua-13318	1	12	1	1	NUM
aiua-13318	1	13	review	review	NOUN
aiua-13318	1	14	introduction	introduction	NOUN
aiua-13318	1	15	benign	benign	ADJ
aiua-13318	1	16	prostatic	prostatic	ADJ
aiua-13318	1	17	hyperplasia	hyperplasia	NOUN
aiua-13318	1	18	(	(	PUNCT
aiua-13318	1	19	bph	bph	NOUN
aiua-13318	1	20	)	)	PUNCT
aiua-13318	1	21	is	be	AUX
aiua-13318	1	22	the	the	DET
aiua-13318	1	23	most	most	ADV
aiua-13318	1	24	common	common	ADJ
aiua-13318	1	25	cause	cause	NOUN
aiua-13318	1	26	of	of	ADP
aiua-13318	1	27	lower	low	ADJ
aiua-13318	1	28	urinary	urinary	ADJ
aiua-13318	1	29	tract	tract	NOUN
aiua-13318	1	30	symptoms	symptom	NOUN
aiua-13318	1	31	(	(	PUNCT
aiua-13318	1	32	luts	luts	PROPN
aiua-13318	1	33	)	)	PUNCT
aiua-13318	1	34	in	in	ADP
aiua-13318	1	35	men	man	NOUN
aiua-13318	1	36	due	due	ADP
aiua-13318	1	37	to	to	ADP
aiua-13318	1	38	bladder	bladder	NOUN
aiua-13318	1	39	outlet	outlet	NOUN
aiua-13318	1	40	obstruction	obstruction	NOUN
aiua-13318	1	41	(	(	PUNCT
aiua-13318	1	42	1	1	NUM
aiua-13318	1	43	)	)	PUNCT
aiua-13318	1	44	.	.	PUNCT
aiua-13318	2	1	symptoms	symptom	NOUN
aiua-13318	2	2	range	range	VERB
aiua-13318	2	3	from	from	ADP
aiua-13318	2	4	increased	increase	VERB
aiua-13318	2	5	urinary	urinary	ADJ
aiua-13318	2	6	hesitancy	hesitancy	NOUN
aiua-13318	2	7	,	,	PUNCT
aiua-13318	2	8	urgency	urgency	NOUN
aiua-13318	2	9	,	,	PUNCT
aiua-13318	2	10	and	and	CCONJ
aiua-13318	2	11	frequency	frequency	NOUN
aiua-13318	2	12	to	to	PART
aiua-13318	2	13	acute	acute	VERB
aiua-13318	2	14	urinary	urinary	ADJ
aiua-13318	2	15	retention	retention	NOUN
aiua-13318	2	16	.	.	PUNCT
aiua-13318	3	1	histologic	histologic	PROPN
aiua-13318	3	2	bph	bph	NOUN
aiua-13318	3	3	is	be	AUX
aiua-13318	3	4	found	find	VERB
aiua-13318	3	5	in	in	ADP
aiua-13318	3	6	approximately	approximately	ADV
aiua-13318	3	7	50	50	NUM
aiua-13318	3	8	%	%	NOUN
aiua-13318	3	9	of	of	ADP
aiua-13318	3	10	men	man	NOUN
aiua-13318	3	11	aged	age	VERB
aiua-13318	3	12	50	50	NUM
aiua-13318	3	13	years	year	NOUN
aiua-13318	3	14	,	,	PUNCT
aiua-13318	3	15	and	and	CCONJ
aiua-13318	3	16	its	its	PRON
aiua-13318	3	17	prevalence	prevalence	NOUN
aiua-13318	3	18	increases	increase	VERB
aiua-13318	3	19	about	about	ADV
aiua-13318	3	20	10	10	NUM
aiua-13318	3	21	%	%	NOUN
aiua-13318	3	22	each	each	DET
aiua-13318	3	23	subsequent	subsequent	ADJ
aiua-13318	3	24	decade	decade	NOUN
aiua-13318	3	25	(	(	PUNCT
aiua-13318	3	26	2	2	NUM
aiua-13318	3	27	)	)	PUNCT
aiua-13318	3	28	.	.	PUNCT
aiua-13318	4	1	likewise	likewise	ADV
aiua-13318	4	2	,	,	PUNCT
aiua-13318	4	3	significant	significant	ADJ
aiua-13318	4	4	luts	lut	NOUN
aiua-13318	4	5	are	be	AUX
aiua-13318	4	6	documented	document	VERB
aiua-13318	4	7	to	to	PART
aiua-13318	4	8	occur	occur	VERB
aiua-13318	4	9	in	in	ADP
aiua-13318	4	10	about	about	ADV
aiua-13318	4	11	10%20	10%20	NUM
aiua-13318	4	12	%	%	NOUN
aiua-13318	4	13	of	of	ADP
aiua-13318	4	14	men	man	NOUN
aiua-13318	4	15	aged	age	VERB
aiua-13318	4	16	50	50	NUM
aiua-13318	4	17	-	-	SYM
aiua-13318	4	18	59	59	NUM
aiua-13318	4	19	and	and	CCONJ
aiua-13318	4	20	increase	increase	VERB
aiua-13318	4	21	to	to	ADP
aiua-13318	4	22	one	one	NUM
aiua-13318	4	23	-	-	PUNCT
aiua-13318	4	24	third	third	NOUN
aiua-13318	4	25	of	of	ADP
aiua-13318	4	26	men	man	NOUN
aiua-13318	4	27	by	by	ADP
aiua-13318	4	28	ages	age	NOUN
aiua-13318	4	29	70	70	NUM
aiua-13318	4	30	-	-	SYM
aiua-13318	4	31	79	79	NUM
aiua-13318	4	32	.	.	PUNCT
aiua-13318	5	1	in	in	ADP
aiua-13318	5	2	parallel	parallel	NOUN
aiua-13318	5	3	,	,	PUNCT
aiua-13318	5	4	prostate	prostate	NOUN
aiua-13318	5	5	volume	volume	NOUN
aiua-13318	5	6	increases	increase	NOUN
aiua-13318	5	7	between	between	ADP
aiua-13318	5	8	age	age	NOUN
aiua-13318	5	9	40	40	NUM
aiua-13318	5	10	and	and	CCONJ
aiua-13318	5	11	age	age	NOUN
aiua-13318	5	12	79	79	NUM
aiua-13318	5	13	,	,	PUNCT
aiua-13318	5	14	with	with	ADP
aiua-13318	5	15	the	the	DET
aiua-13318	5	16	greatest	great	ADJ
aiua-13318	5	17	increases	increase	NOUN
aiua-13318	5	18	appearing	appear	VERB
aiua-13318	5	19	in	in	ADP
aiua-13318	5	20	the	the	DET
aiua-13318	5	21	sixth	sixth	ADJ
aiua-13318	5	22	and	and	CCONJ
aiua-13318	5	23	seventh	seventh	ADJ
aiua-13318	5	24	decades	decade	NOUN
aiua-13318	5	25	of	of	ADP
aiua-13318	5	26	life	life	NOUN
aiua-13318	5	27	(	(	PUNCT
aiua-13318	5	28	3	3	NUM
aiua-13318	5	29	)	)	PUNCT
aiua-13318	5	30	.	.	PUNCT
aiua-13318	6	1	recent	recent	ADJ
aiua-13318	6	2	studies	study	NOUN
aiua-13318	6	3	have	have	AUX
aiua-13318	6	4	uncovered	uncover	VERB
aiua-13318	6	5	several	several	ADJ
aiua-13318	6	6	genes	gene	NOUN
aiua-13318	6	7	linked	link	VERB
aiua-13318	6	8	to	to	ADP
aiua-13318	6	9	both	both	DET
aiua-13318	6	10	bph	bph	NOUN
aiua-13318	6	11	and	and	CCONJ
aiua-13318	6	12	prostate	prostate	NOUN
aiua-13318	6	13	cancer	cancer	NOUN
aiua-13318	6	14	.	.	PUNCT
aiua-13318	7	1	for	for	ADP
aiua-13318	7	2	instance	instance	NOUN
aiua-13318	7	3	,	,	PUNCT
aiua-13318	7	4	li	li	PROPN
aiua-13318	7	5	et	et	PROPN
aiua-13318	7	6	al	al	PROPN
aiua-13318	7	7	.	.	PROPN
aiua-13318	8	1	(	(	PUNCT
aiua-13318	8	2	4	4	X
aiua-13318	8	3	)	)	PUNCT
aiua-13318	8	4	investigated	investigate	VERB
aiua-13318	8	5	the	the	DET
aiua-13318	8	6	v89l	v89l	PROPN
aiua-13318	8	7	and	and	CCONJ
aiua-13318	8	8	a49	a49	PROPN
aiua-13318	8	9	t	t	PROPN
aiua-13318	8	10	srda52	srda52	NOUN
aiua-13318	8	11	polymorphisms	polymorphism	NOUN
aiua-13318	8	12	,	,	PUNCT
aiua-13318	8	13	while	while	SCONJ
aiua-13318	8	14	zhang	zhang	PROPN
aiua-13318	8	15	et	et	PROPN
aiua-13318	8	16	al	al	PROPN
aiua-13318	8	17	.	.	PROPN
aiua-13318	8	18	expanded	expand	VERB
aiua-13318	8	19	the	the	DET
aiua-13318	8	20	search	search	NOUN
aiua-13318	8	21	by	by	ADP
aiua-13318	8	22	examining	examine	VERB
aiua-13318	8	23	genotype	genotype	NOUN
aiua-13318	8	24	distributions	distribution	NOUN
aiua-13318	8	25	of	of	ADP
aiua-13318	8	26	srd5a2	srd5a2	NOUN
aiua-13318	8	27	,	,	PUNCT
aiua-13318	8	28	cyp17	cyp17	NOUN
aiua-13318	8	29	,	,	PUNCT
aiua-13318	8	30	cyp19	cyp19	NOUN
aiua-13318	8	31	,	,	PUNCT
aiua-13318	8	32	and	and	CCONJ
aiua-13318	8	33	vdr	vdr	VERB
aiua-13318	8	34	genes	gene	NOUN
aiua-13318	8	35	in	in	ADP
aiua-13318	8	36	chinese	chinese	ADJ
aiua-13318	8	37	populations	population	NOUN
aiua-13318	8	38	(	(	PUNCT
aiua-13318	8	39	4	4	NUM
aiua-13318	8	40	,	,	PUNCT
aiua-13318	8	41	5	5	NUM
aiua-13318	8	42	)	)	PUNCT
aiua-13318	8	43	.	.	PUNCT
aiua-13318	9	1	additionally	additionally	ADV
aiua-13318	9	2	,	,	PUNCT
aiua-13318	9	3	choubey	choubey	VERB
aiua-13318	9	4	et	et	PROPN
aiua-13318	9	5	al	al	PROPN
aiua-13318	9	6	.	.	PROPN
aiua-13318	10	1	(	(	PUNCT
aiua-13318	10	2	5	5	X
aiua-13318	10	3	)	)	PUNCT
aiua-13318	10	4	focused	focus	VERB
aiua-13318	10	5	on	on	ADP
aiua-13318	10	6	polymorphisms	polymorphism	NOUN
aiua-13318	10	7	at	at	ADP
aiua-13318	10	8	the	the	DET
aiua-13318	10	9	(	(	PUNCT
aiua-13318	10	10	ta)n	ta)n	PROPN
aiua-13318	10	11	locus	locus	NOUN
aiua-13318	10	12	.	.	PUNCT
aiua-13318	11	1	together	together	ADV
aiua-13318	11	2	,	,	PUNCT
aiua-13318	11	3	these	these	DET
aiua-13318	11	4	investigations	investigation	NOUN
aiua-13318	11	5	,	,	PUNCT
aiua-13318	11	6	alongside	alongside	ADP
aiua-13318	11	7	others	other	NOUN
aiua-13318	11	8	exploring	explore	VERB
aiua-13318	11	9	correlations	correlation	NOUN
aiua-13318	11	10	across	across	ADP
aiua-13318	11	11	diverse	diverse	ADJ
aiua-13318	11	12	populations	population	NOUN
aiua-13318	11	13	,	,	PUNCT
aiua-13318	11	14	significantly	significantly	ADV
aiua-13318	11	15	enhanced	enhance	VERB
aiua-13318	11	16	our	our	PRON
aiua-13318	11	17	understanding	understanding	NOUN
aiua-13318	11	18	of	of	ADP
aiua-13318	11	19	the	the	DET
aiua-13318	11	20	genetic	genetic	ADJ
aiua-13318	11	21	factors	factor	NOUN
aiua-13318	11	22	that	that	PRON
aiua-13318	11	23	may	may	AUX
aiua-13318	11	24	impact	impact	VERB
aiua-13318	11	25	the	the	DET
aiua-13318	11	26	development	development	NOUN
aiua-13318	11	27	of	of	ADP
aiua-13318	11	28	bph	bph	NOUN
aiua-13318	11	29	and	and	CCONJ
aiua-13318	11	30	prostate	prostate	NOUN
aiua-13318	11	31	cancer	cancer	NOUN
aiua-13318	11	32	.	.	PUNCT
aiua-13318	12	1	previous	previous	ADJ
aiua-13318	12	2	researchers	researcher	NOUN
aiua-13318	12	3	have	have	AUX
aiua-13318	12	4	noted	note	VERB
aiua-13318	12	5	the	the	DET
aiua-13318	12	6	presence	presence	NOUN
aiua-13318	12	7	of	of	ADP
aiua-13318	12	8	alleles	allele	NOUN
aiua-13318	12	9	with	with	ADP
aiua-13318	12	10	low	low	ADJ
aiua-13318	12	11	catabolic	catabolic	ADJ
aiua-13318	12	12	activity	activity	NOUN
aiua-13318	12	13	including	include	VERB
aiua-13318	12	14	two	two	NUM
aiua-13318	12	15	polymorphic	polymorphic	ADJ
aiua-13318	12	16	sites	site	NOUN
aiua-13318	12	17	:	:	PUNCT
aiua-13318	12	18	an	an	DET
aiua-13318	12	19	alanine	alanine	NOUN
aiua-13318	12	20	to	to	ADP
aiua-13318	12	21	threonine	threonine	ADJ
aiua-13318	12	22	substitution	substitution	NOUN
aiua-13318	12	23	at	at	ADP
aiua-13318	12	24	codon	codon	NOUN
aiua-13318	12	25	49	49	NUM
aiua-13318	12	26	(	(	PUNCT
aiua-13318	12	27	a49	a49	PROPN
aiua-13318	12	28	t	t	PROPN
aiua-13318	12	29	)	)	PUNCT
aiua-13318	12	30	and	and	CCONJ
aiua-13318	12	31	a	a	DET
aiua-13318	12	32	valine	valine	NOUN
aiua-13318	12	33	to	to	PART
aiua-13318	12	34	leucine	leucine	NOUN
aiua-13318	12	35	substitution	substitution	NOUN
aiua-13318	12	36	at	at	ADP
aiua-13318	12	37	codon	codon	PROPN
aiua-13318	12	38	89	89	NUM
aiua-13318	12	39	(	(	PUNCT
aiua-13318	12	40	v89l	v89l	PROPN
aiua-13318	12	41	)	)	PUNCT
aiua-13318	12	42	(	(	PUNCT
aiua-13318	12	43	6	6	NUM
aiua-13318	12	44	)	)	PUNCT
aiua-13318	12	45	.	.	PUNCT
aiua-13318	13	1	the	the	DET
aiua-13318	13	2	v89l	v89l	PROPN
aiua-13318	13	3	polymorphism	polymorphism	NOUN
aiua-13318	13	4	correlates	correlate	VERB
aiua-13318	13	5	with	with	ADP
aiua-13318	13	6	reduced	reduced	ADJ
aiua-13318	13	7	concentrations	concentration	NOUN
aiua-13318	13	8	of	of	ADP
aiua-13318	13	9	androstanediol	androstanediol	PROPN
aiua-13318	13	10	glucuronide	glucuronide	NOUN
aiua-13318	13	11	,	,	PUNCT
aiua-13318	13	12	free	free	ADJ
aiua-13318	13	13	testosterone	testosterone	NOUN
aiua-13318	13	14	,	,	PUNCT
aiua-13318	13	15	and	and	CCONJ
aiua-13318	13	16	testosterone	testosterone	NOUN
aiua-13318	13	17	(	(	PUNCT
aiua-13318	13	18	7	7	NUM
aiua-13318	13	19	)	)	PUNCT
aiua-13318	13	20	.	.	PUNCT
aiua-13318	14	1	individuals	individual	NOUN
aiua-13318	14	2	with	with	ADP
aiua-13318	14	3	the	the	DET
aiua-13318	14	4	“	"	PUNCT
aiua-13318	14	5	ll	ll	NOUN
aiua-13318	14	6	”	"	PUNCT
aiua-13318	14	7	genotype	genotype	NOUN
aiua-13318	14	8	exhibit	exhibit	NOUN
aiua-13318	14	9	a	a	DET
aiua-13318	14	10	slight	slight	ADJ
aiua-13318	14	11	,	,	PUNCT
aiua-13318	14	12	nonsignificant	nonsignificant	ADJ
aiua-13318	14	13	,	,	PUNCT
aiua-13318	14	14	decrease	decrease	NOUN
aiua-13318	14	15	in	in	ADP
aiua-13318	14	16	androstanediol	androstanediol	PROPN
aiua-13318	14	17	glucuronide	glucuronide	PROPN
aiua-13318	14	18	concentrations	concentration	NOUN
aiua-13318	14	19	compared	compare	VERB
aiua-13318	14	20	to	to	ADP
aiua-13318	14	21	those	those	PRON
aiua-13318	14	22	with	with	ADP
aiua-13318	14	23	the	the	DET
aiua-13318	14	24	“	"	PUNCT
aiua-13318	14	25	vv	vv	NOUN
aiua-13318	14	26	”	"	PUNCT
aiua-13318	14	27	genotype	genotype	NOUN
aiua-13318	14	28	.	.	PUNCT
aiua-13318	15	1	the	the	DET
aiua-13318	15	2	l	l	PROPN
aiua-13318	15	3	allele	allele	PROPN
aiua-13318	15	4	's	's	PART
aiua-13318	15	5	moderate	moderate	ADJ
aiua-13318	15	6	reduction	reduction	NOUN
aiua-13318	15	7	in	in	ADP
aiua-13318	15	8	srd5a2	srd5a2	NOUN
aiua-13318	15	9	activity	activity	NOUN
aiua-13318	15	10	results	result	NOUN
aiua-13318	15	11	in	in	ADP
aiua-13318	15	12	lower	low	ADJ
aiua-13318	15	13	dihydrotestosterone	dihydrotestosterone	NOUN
aiua-13318	15	14	(	(	PUNCT
aiua-13318	15	15	dht	dht	NOUN
aiua-13318	15	16	)	)	PUNCT
aiua-13318	15	17	levels	level	NOUN
aiua-13318	15	18	,	,	PUNCT
aiua-13318	15	19	although	although	SCONJ
aiua-13318	15	20	the	the	DET
aiua-13318	15	21	biological	biological	ADJ
aiua-13318	15	22	mechanism	mechanism	NOUN
aiua-13318	15	23	behind	behind	ADP
aiua-13318	15	24	this	this	DET
aiua-13318	15	25	genotype	genotype	NOUN
aiua-13318	15	26	's	's	PART
aiua-13318	15	27	connection	connection	NOUN
aiua-13318	15	28	with	with	ADP
aiua-13318	15	29	decreased	decrease	VERB
aiua-13318	15	30	dht	dht	NOUN
aiua-13318	15	31	production	production	NOUN
aiua-13318	15	32	remains	remain	VERB
aiua-13318	15	33	unclear	unclear	ADJ
aiua-13318	15	34	(	(	PUNCT
aiua-13318	15	35	4	4	NUM
aiua-13318	15	36	)	)	PUNCT
aiua-13318	15	37	.	.	PUNCT
aiua-13318	16	1	however	however	ADV
aiua-13318	16	2	,	,	PUNCT
aiua-13318	16	3	dht	dht	NOUN
aiua-13318	16	4	levels	level	NOUN
aiua-13318	16	5	in	in	ADP
aiua-13318	16	6	the	the	DET
aiua-13318	16	7	prostate	prostate	NOUN
aiua-13318	16	8	are	be	AUX
aiua-13318	16	9	influenced	influence	VERB
aiua-13318	16	10	by	by	ADP
aiua-13318	16	11	various	various	ADJ
aiua-13318	16	12	factors	factor	NOUN
aiua-13318	16	13	,	,	PUNCT
aiua-13318	16	14	including	include	VERB
aiua-13318	16	15	testosterone	testosterone	NOUN
aiua-13318	16	16	metabolism	metabolism	NOUN
aiua-13318	16	17	and	and	CCONJ
aiua-13318	16	18	dht	dht	NOUN
aiua-13318	16	19	inactivation	inactivation	NOUN
aiua-13318	16	20	.	.	PUNCT
aiua-13318	17	1	testosterone	testosterone	NOUN
aiua-13318	17	2	,	,	PUNCT
aiua-13318	17	3	not	not	PART
aiua-13318	17	4	dht	dht	NOUN
aiua-13318	17	5	,	,	PUNCT
aiua-13318	17	6	appears	appear	VERB
aiua-13318	17	7	to	to	PART
aiua-13318	17	8	be	be	AUX
aiua-13318	17	9	the	the	DET
aiua-13318	17	10	primary	primary	ADJ
aiua-13318	17	11	androgen	androgen	NOUN
aiua-13318	17	12	promoting	promote	VERB
aiua-13318	17	13	prostate	prostate	NOUN
aiua-13318	17	14	introduction	introduction	NOUN
aiua-13318	17	15	and	and	CCONJ
aiua-13318	17	16	objectives	objective	NOUN
aiua-13318	17	17	:	:	PUNCT
aiua-13318	17	18	being	be	AUX
aiua-13318	17	19	the	the	DET
aiua-13318	17	20	most	most	ADV
aiua-13318	17	21	common	common	ADJ
aiua-13318	17	22	disease	disease	NOUN
aiua-13318	17	23	in	in	ADP
aiua-13318	17	24	aged	aged	ADJ
aiua-13318	17	25	men	man	NOUN
aiua-13318	17	26	,	,	PUNCT
aiua-13318	17	27	the	the	DET
aiua-13318	17	28	etiology	etiology	NOUN
aiua-13318	17	29	of	of	ADP
aiua-13318	17	30	benign	benign	ADJ
aiua-13318	17	31	prostatic	prostatic	ADJ
aiua-13318	17	32	hyperplasia	hyperplasia	NOUN
aiua-13318	17	33	(	(	PUNCT
aiua-13318	17	34	bph	bph	NOUN
aiua-13318	17	35	)	)	PUNCT
aiua-13318	17	36	is	be	AUX
aiua-13318	17	37	not	not	PART
aiua-13318	17	38	fully	fully	ADV
aiua-13318	17	39	defined	define	VERB
aiua-13318	17	40	.	.	PUNCT
aiua-13318	18	1	recent	recent	ADJ
aiua-13318	18	2	studies	study	NOUN
aiua-13318	18	3	have	have	AUX
aiua-13318	18	4	reported	report	VERB
aiua-13318	18	5	that	that	SCONJ
aiua-13318	18	6	the	the	DET
aiua-13318	18	7	association	association	NOUN
aiua-13318	18	8	between	between	ADP
aiua-13318	18	9	benign	benign	ADJ
aiua-13318	18	10	prostate	prostate	NOUN
aiua-13318	18	11	hyperplasia	hyperplasia	NOUN
aiua-13318	18	12	and	and	CCONJ
aiua-13318	18	13	metabolic	metabolic	NOUN
aiua-13318	18	14	genes	gene	NOUN
aiua-13318	18	15	is	be	AUX
aiua-13318	18	16	still	still	ADV
aiua-13318	18	17	inconsistent	inconsistent	ADJ
aiua-13318	18	18	.	.	PUNCT
aiua-13318	19	1	a	a	DET
aiua-13318	19	2	gene	gene	NOUN
aiua-13318	19	3	connected	connect	VERB
aiua-13318	19	4	with	with	ADP
aiua-13318	19	5	bph	bph	NOUN
aiua-13318	19	6	is	be	AUX
aiua-13318	19	7	srd5ar2	srd5ar2	PROPN
aiua-13318	19	8	,	,	PUNCT
aiua-13318	19	9	whose	whose	DET
aiua-13318	19	10	polymorphisms	polymorphism	NOUN
aiua-13318	19	11	,	,	PUNCT
aiua-13318	19	12	a49	a49	PROPN
aiua-13318	19	13	t	t	PROPN
aiua-13318	19	14	and	and	CCONJ
aiua-13318	19	15	v89l	v89l	VERB
aiua-13318	19	16	,	,	PUNCT
aiua-13318	19	17	have	have	VERB
aiua-13318	19	18	distinct	distinct	ADJ
aiua-13318	19	19	enzyme	enzyme	NOUN
aiua-13318	19	20	activity	activity	NOUN
aiua-13318	19	21	.	.	PUNCT
aiua-13318	20	1	this	this	DET
aiua-13318	20	2	systematic	systematic	ADJ
aiua-13318	20	3	review	review	NOUN
aiua-13318	20	4	examines	examine	VERB
aiua-13318	20	5	srd5ar2	srd5ar2	PROPN
aiua-13318	20	6	polymorphisms	polymorphism	NOUN
aiua-13318	20	7	within	within	ADP
aiua-13318	20	8	two	two	NUM
aiua-13318	20	9	alleles	allele	NOUN
aiua-13318	20	10	(	(	PUNCT
aiua-13318	20	11	a49	a49	PROPN
aiua-13318	20	12	t	t	PROPN
aiua-13318	20	13	and	and	CCONJ
aiua-13318	20	14	v89l	v89l	PROPN
aiua-13318	20	15	)	)	PUNCT
aiua-13318	20	16	,	,	PUNCT
aiua-13318	20	17	assessing	assess	VERB
aiua-13318	20	18	their	their	PRON
aiua-13318	20	19	roles	role	NOUN
aiua-13318	20	20	as	as	ADP
aiua-13318	20	21	prognostic	prognostic	ADJ
aiua-13318	20	22	indicators	indicator	NOUN
aiua-13318	20	23	of	of	ADP
aiua-13318	20	24	malignancy	malignancy	NOUN
aiua-13318	20	25	,	,	PUNCT
aiua-13318	20	26	and	and	CCONJ
aiua-13318	20	27	response	response	NOUN
aiua-13318	20	28	to	to	ADP
aiua-13318	20	29	medication	medication	NOUN
aiua-13318	20	30	.	.	PUNCT
aiua-13318	21	1	materials	material	NOUN
aiua-13318	21	2	and	and	CCONJ
aiua-13318	21	3	methods	method	NOUN
aiua-13318	21	4	:	:	PUNCT
aiua-13318	21	5	we	we	PRON
aiua-13318	21	6	conducted	conduct	VERB
aiua-13318	21	7	a	a	DET
aiua-13318	21	8	search	search	NOUN
aiua-13318	21	9	on	on	ADP
aiua-13318	21	10	six	six	NUM
aiua-13318	21	11	different	different	ADJ
aiua-13318	21	12	databases	database	NOUN
aiua-13318	21	13	,	,	PUNCT
aiua-13318	21	14	including	include	VERB
aiua-13318	21	15	pubmed	pubmed	PROPN
aiua-13318	21	16	,	,	PUNCT
aiua-13318	21	17	scopus	scopus	PROPN
aiua-13318	21	18	,	,	PUNCT
aiua-13318	21	19	wiley	wiley	NOUN
aiua-13318	21	20	,	,	PUNCT
aiua-13318	21	21	proquest	proquest	PROPN
aiua-13318	21	22	,	,	PUNCT
aiua-13318	21	23	cochrane	cochrane	PROPN
aiua-13318	21	24	central	central	NOUN
aiua-13318	21	25	,	,	PUNCT
aiua-13318	21	26	and	and	CCONJ
aiua-13318	21	27	science	science	NOUN
aiua-13318	21	28	direct	direct	ADJ
aiua-13318	21	29	using	using	NOUN
aiua-13318	21	30	as	as	ADP
aiua-13318	21	31	string	string	NOUN
aiua-13318	21	32	of	of	ADP
aiua-13318	21	33	keywords	keyword	NOUN
aiua-13318	21	34	(	(	PUNCT
aiua-13318	21	35	bph	bph	NOUN
aiua-13318	21	36	)	)	PUNCT
aiua-13318	21	37	and	and	CCONJ
aiua-13318	21	38	[	[	X
aiua-13318	21	39	(	(	PUNCT
aiua-13318	21	40	rs523349	rs523349	PROPN
aiua-13318	21	41	)	)	PUNCT
aiua-13318	21	42	or	or	CCONJ
aiua-13318	21	43	(	(	PUNCT
aiua-13318	21	44	v89l	v89l	PROPN
aiua-13318	21	45	)	)	PUNCT
aiua-13318	21	46	]	]	PUNCT
aiua-13318	21	47	and	and	CCONJ
aiua-13318	21	48	[	[	X
aiua-13318	21	49	(	(	PUNCT
aiua-13318	21	50	rs9282858	rs9282858	NOUN
aiua-13318	21	51	)	)	PUNCT
aiua-13318	21	52	or	or	CCONJ
aiua-13318	21	53	(	(	PUNCT
aiua-13318	21	54	a49	a49	PROPN
aiua-13318	21	55	t	t	PROPN
aiua-13318	21	56	)	)	PUNCT
aiua-13318	21	57	]	]	PUNCT
aiua-13318	21	58	.	.	PUNCT
aiua-13318	22	1	we	we	PRON
aiua-13318	22	2	finally	finally	ADV
aiua-13318	22	3	selected	select	VERB
aiua-13318	22	4	seven	seven	NUM
aiua-13318	22	5	articles	article	NOUN
aiua-13318	22	6	to	to	PART
aiua-13318	22	7	be	be	AUX
aiua-13318	22	8	extracted	extract	VERB
aiua-13318	22	9	.	.	PUNCT
aiua-13318	23	1	quality	quality	NOUN
aiua-13318	23	2	appraisal	appraisal	NOUN
aiua-13318	23	3	of	of	ADP
aiua-13318	23	4	clinical	clinical	ADJ
aiua-13318	23	5	trials	trial	NOUN
aiua-13318	23	6	was	be	AUX
aiua-13318	23	7	evaluated	evaluate	VERB
aiua-13318	23	8	using	use	VERB
aiua-13318	23	9	the	the	DET
aiua-13318	23	10	joanna	joanna	PROPN
aiua-13318	23	11	briggs	briggs	PROPN
aiua-13318	23	12	institute	institute	PROPN
aiua-13318	23	13	approach	approach	PROPN
aiua-13318	23	14	for	for	ADP
aiua-13318	23	15	systematic	systematic	ADJ
aiua-13318	23	16	reviews	review	NOUN
aiua-13318	23	17	.	.	PUNCT
aiua-13318	24	1	results	result	NOUN
aiua-13318	24	2	:	:	PUNCT
aiua-13318	24	3	we	we	PRON
aiua-13318	24	4	sorted	sort	VERB
aiua-13318	24	5	nine	nine	NUM
aiua-13318	24	6	clinical	clinical	ADJ
aiua-13318	24	7	studies	study	NOUN
aiua-13318	24	8	from	from	ADP
aiua-13318	24	9	various	various	ADJ
aiua-13318	24	10	countries	country	NOUN
aiua-13318	24	11	examining	examine	VERB
aiua-13318	24	12	srda52	srda52	NOUN
aiua-13318	24	13	polymorphism	polymorphism	NOUN
aiua-13318	24	14	and	and	CCONJ
aiua-13318	24	15	its	its	PRON
aiua-13318	24	16	association	association	NOUN
aiua-13318	24	17	of	of	ADP
aiua-13318	24	18	bph	bph	NOUN
aiua-13318	24	19	and	and	CCONJ
aiua-13318	24	20	prostate	prostate	NOUN
aiua-13318	24	21	cancer	cancer	NOUN
aiua-13318	24	22	.	.	PUNCT
aiua-13318	25	1	about	about	ADP
aiua-13318	25	2	v89l	v89l	PROPN
aiua-13318	25	3	we	we	PRON
aiua-13318	25	4	found	find	VERB
aiua-13318	25	5	that	that	SCONJ
aiua-13318	25	6	the	the	DET
aiua-13318	25	7	"	"	PUNCT
aiua-13318	25	8	ll	ll	NOUN
aiua-13318	25	9	"	"	PUNCT
aiua-13318	25	10	genotype	genotype	NOUN
aiua-13318	25	11	,	,	PUNCT
aiua-13318	25	12	indicating	indicate	VERB
aiua-13318	25	13	reduced	reduce	VERB
aiua-13318	25	14	5α	5α	ADJ
aiua-13318	25	15	-	-	PUNCT
aiua-13318	25	16	reductase	reductase	NOUN
aiua-13318	25	17	activity	activity	NOUN
aiua-13318	25	18	,	,	PUNCT
aiua-13318	25	19	is	be	AUX
aiua-13318	25	20	linked	link	VERB
aiua-13318	25	21	to	to	ADP
aiua-13318	25	22	a	a	DET
aiua-13318	25	23	lower	low	ADJ
aiua-13318	25	24	bph	bph	NOUN
aiua-13318	25	25	risk	risk	NOUN
aiua-13318	25	26	,	,	PUNCT
aiua-13318	25	27	while	while	SCONJ
aiua-13318	25	28	the	the	DET
aiua-13318	25	29	"	"	PUNCT
aiua-13318	25	30	vv	vv	NOUN
aiua-13318	25	31	"	"	PUNCT
aiua-13318	25	32	genotype	genotype	NOUN
aiua-13318	25	33	may	may	AUX
aiua-13318	25	34	slightly	slightly	ADV
aiua-13318	25	35	increase	increase	VERB
aiua-13318	25	36	bph	bph	NOUN
aiua-13318	25	37	risk	risk	NOUN
aiua-13318	25	38	.	.	PUNCT
aiua-13318	26	1	about	about	ADP
aiua-13318	26	2	a49	a49	PROPN
aiua-13318	26	3	t	t	PROPN
aiua-13318	26	4	,	,	PUNCT
aiua-13318	26	5	compared	compare	VERB
aiua-13318	26	6	to	to	ADP
aiua-13318	26	7	“	"	PUNCT
aiua-13318	26	8	aa	aa	INTJ
aiua-13318	26	9	”	"	PUNCT
aiua-13318	26	10	genotype	genotype	NOUN
aiua-13318	26	11	,	,	PUNCT
aiua-13318	26	12	“	"	PUNCT
aiua-13318	26	13	at	at	ADP
aiua-13318	26	14	”	"	PUNCT
aiua-13318	26	15	tends	tend	VERB
aiua-13318	26	16	to	to	PART
aiua-13318	26	17	be	be	AUX
aiua-13318	26	18	associated	associate	VERB
aiua-13318	26	19	to	to	ADP
aiua-13318	26	20	higher	high	ADJ
aiua-13318	26	21	risk	risk	NOUN
aiua-13318	26	22	in	in	ADP
aiua-13318	26	23	developing	develop	VERB
aiua-13318	26	24	prostate	prostate	NOUN
aiua-13318	26	25	cancer	cancer	NOUN
aiua-13318	26	26	.	.	PUNCT
aiua-13318	27	1	a49	a49	PROPN
aiua-13318	27	2	t	t	PROPN
aiua-13318	27	3	polymorphism	polymorphism	NOUN
aiua-13318	27	4	does	do	AUX
aiua-13318	27	5	not	not	PART
aiua-13318	27	6	show	show	VERB
aiua-13318	27	7	any	any	DET
aiua-13318	27	8	effect	effect	NOUN
aiua-13318	27	9	on	on	ADP
aiua-13318	27	10	medical	medical	ADJ
aiua-13318	27	11	treatment	treatment	NOUN
aiua-13318	27	12	while	while	SCONJ
aiua-13318	27	13	v89l	v89l	PROPN
aiua-13318	27	14	showed	show	VERB
aiua-13318	27	15	a	a	DET
aiua-13318	27	16	protective	protective	ADJ
aiua-13318	27	17	effect	effect	NOUN
aiua-13318	27	18	on	on	ADP
aiua-13318	27	19	the	the	DET
aiua-13318	27	20	clinical	clinical	ADJ
aiua-13318	27	21	progression	progression	NOUN
aiua-13318	27	22	of	of	ADP
aiua-13318	27	23	bph	bph	NOUN
aiua-13318	27	24	when	when	SCONJ
aiua-13318	27	25	treated	treat	VERB
aiua-13318	27	26	with	with	ADP
aiua-13318	27	27	5a	5a	NUM
aiua-13318	27	28	-	-	PUNCT
aiua-13318	27	29	reductase	reductase	NOUN
aiua-13318	27	30	inhibitors	inhibitor	NOUN
aiua-13318	27	31	,	,	PUNCT
aiua-13318	27	32	aadrenergic	aadrenergic	NOUN
aiua-13318	27	33	receptor	receptor	NOUN
aiua-13318	27	34	antagonists	antagonist	NOUN
aiua-13318	27	35	,	,	PUNCT
aiua-13318	27	36	and	and	CCONJ
aiua-13318	27	37	alpha	alpha	NOUN
aiua-13318	27	38	blockers	blocker	NOUN
aiua-13318	27	39	.	.	PUNCT
aiua-13318	28	1	conclusions	conclusion	NOUN
aiua-13318	28	2	:	:	PUNCT
aiua-13318	28	3	srd5a2	srd5a2	NOUN
aiua-13318	28	4	polymorphisms	polymorphism	NOUN
aiua-13318	28	5	could	could	AUX
aiua-13318	28	6	be	be	AUX
aiua-13318	28	7	a	a	DET
aiua-13318	28	8	good	good	ADJ
aiua-13318	28	9	indicator	indicator	NOUN
aiua-13318	28	10	for	for	ADP
aiua-13318	28	11	prognostic	prognostic	ADJ
aiua-13318	28	12	malignancy	malignancy	NOUN
aiua-13318	28	13	and	and	CCONJ
aiua-13318	28	14	a	a	DET
aiua-13318	28	15	potential	potential	ADJ
aiua-13318	28	16	tool	tool	NOUN
aiua-13318	28	17	for	for	ADP
aiua-13318	28	18	personalized	personalized	ADJ
aiua-13318	28	19	medicine	medicine	NOUN
aiua-13318	28	20	of	of	ADP
aiua-13318	28	21	bph	bph	NOUN
aiua-13318	28	22	.	.	PUNCT
aiua-13318	29	1	the	the	DET
aiua-13318	29	2	findings	finding	NOUN
aiua-13318	29	3	strongly	strongly	ADV
aiua-13318	29	4	support	support	VERB
aiua-13318	29	5	the	the	DET
aiua-13318	29	6	recommendation	recommendation	NOUN
aiua-13318	29	7	for	for	ADP
aiua-13318	29	8	further	further	ADJ
aiua-13318	29	9	study	study	NOUN
aiua-13318	29	10	about	about	ADP
aiua-13318	29	11	srd5ar2	srd5ar2	PROPN
aiua-13318	29	12	to	to	PART
aiua-13318	29	13	enhance	enhance	VERB
aiua-13318	29	14	its	its	PRON
aiua-13318	29	15	use	use	NOUN
aiua-13318	29	16	for	for	ADP
aiua-13318	29	17	screening	screening	NOUN
aiua-13318	29	18	and	and	CCONJ
aiua-13318	29	19	prevention	prevention	NOUN
aiua-13318	29	20	and	and	CCONJ
aiua-13318	29	21	to	to	PART
aiua-13318	29	22	optimize	optimize	VERB
aiua-13318	29	23	the	the	DET
aiua-13318	29	24	medical	medical	ADJ
aiua-13318	29	25	treatment	treatment	NOUN
aiua-13318	29	26	of	of	ADP
aiua-13318	29	27	benign	benign	ADJ
aiua-13318	29	28	prostatic	prostatic	ADJ
aiua-13318	29	29	hyperplasia	hyperplasia	NOUN
aiua-13318	29	30	.	.	PUNCT
aiua-13318	30	1	key	key	ADJ
aiua-13318	30	2	words	word	NOUN
aiua-13318	30	3	:	:	PUNCT
aiua-13318	30	4	benign	benign	ADJ
aiua-13318	30	5	prostatic	prostatic	ADJ
aiua-13318	30	6	hyperplasia	hyperplasia	NOUN
aiua-13318	30	7	;	;	PUNCT
aiua-13318	30	8	prostate	prostate	NOUN
aiua-13318	30	9	cancer	cancer	NOUN
aiua-13318	30	10	;	;	PUNCT
aiua-13318	30	11	genetic	genetic	ADJ
aiua-13318	30	12	polymorphism	polymorphism	NOUN
aiua-13318	30	13	;	;	PUNCT
aiua-13318	30	14	prognosis	prognosis	NOUN
aiua-13318	30	15	;	;	PUNCT
aiua-13318	30	16	personalized	personalized	ADJ
aiua-13318	30	17	medicine	medicine	NOUN
aiua-13318	30	18	.	.	PUNCT
aiua-13318	30	19	submitted	submit	VERB
aiua-13318	30	20	30	30	NUM
aiua-13318	30	21	october	october	NOUN
aiua-13318	30	22	2024	2024	NUM
aiua-13318	30	23	;	;	PUNCT
aiua-13318	30	24	accepted	accept	VERB
aiua-13318	30	25	5	5	NUM
aiua-13318	30	26	december	december	PROPN
aiua-13318	30	27	2024	2024	NUM
aiua-13318	30	28	a	a	DET
aiua-13318	30	29	comprehensive	comprehensive	ADJ
aiua-13318	30	30	systematic	systematic	ADJ
aiua-13318	30	31	review	review	NOUN
aiua-13318	30	32	of	of	ADP
aiua-13318	30	33	studies	study	NOUN
aiua-13318	30	34	on	on	ADP
aiua-13318	30	35	the	the	DET
aiua-13318	30	36	potential	potential	NOUN
aiua-13318	30	37	of	of	ADP
aiua-13318	30	38	a49	a49	PROPN
aiua-13318	30	39	t	t	PROPN
aiua-13318	30	40	and	and	CCONJ
aiua-13318	30	41	v89l	v89l	VERB
aiua-13318	30	42	polymorphism	polymorphism	NOUN
aiua-13318	30	43	in	in	ADP
aiua-13318	30	44	srd5ar2	srd5ar2	PROPN
aiua-13318	30	45	as	as	ADP
aiua-13318	30	46	high	high	ADJ
aiua-13318	30	47	susceptibility	susceptibility	NOUN
aiua-13318	30	48	gene	gene	NOUN
aiua-13318	30	49	association	association	NOUN
aiua-13318	30	50	with	with	ADP
aiua-13318	30	51	benign	benign	ADJ
aiua-13318	30	52	prostate	prostate	NOUN
aiua-13318	30	53	hyperplasia	hyperplasia	NOUN
aiua-13318	30	54	and	and	CCONJ
aiua-13318	30	55	prostate	prostate	NOUN
aiua-13318	30	56	cancer	cancer	NOUN
aiua-13318	30	57	revina	revina	NOUN
aiua-13318	30	58	maharani	maharani	PROPN
aiua-13318	30	59	1	1	NUM
aiua-13318	30	60	,	,	PUNCT
aiua-13318	30	61	hotma	hotma	PROPN
aiua-13318	30	62	lestari	lestari	PROPN
aiua-13318	30	63	1	1	NUM
aiua-13318	30	64	,	,	PUNCT
aiua-13318	30	65	putra	putra	PROPN
aiua-13318	30	66	mahakarya	mahakarya	PROPN
aiua-13318	30	67	dewa	dewa	PROPN
aiua-13318	30	68	1	1	NUM
aiua-13318	30	69	,	,	PUNCT
aiua-13318	30	70	dewangga	dewangga	NOUN
aiua-13318	30	71	yudisthira	yudisthira	PROPN
aiua-13318	30	72	1	1	NUM
aiua-13318	30	73	,	,	PUNCT
aiua-13318	30	74	nasim	nasim	PROPN
aiua-13318	30	75	amar	amar	PROPN
aiua-13318	30	76	1	1	NUM
aiua-13318	30	77	,	,	PUNCT
aiua-13318	30	78	besut	besut	NOUN
aiua-13318	30	79	daryanto	daryanto	ADP
aiua-13318	30	80	2	2	NUM
aiua-13318	30	81	1	1	NUM
aiua-13318	30	82	medical	medical	ADJ
aiua-13318	30	83	faculty	faculty	NOUN
aiua-13318	30	84	,	,	PUNCT
aiua-13318	30	85	universitas	universita	NOUN
aiua-13318	30	86	brawijaya	brawijaya	PROPN
aiua-13318	30	87	,	,	PUNCT
aiua-13318	30	88	malang	malang	PROPN
aiua-13318	30	89	,	,	PUNCT
aiua-13318	30	90	indonesia	indonesia	PROPN
aiua-13318	30	91	;	;	PUNCT
aiua-13318	30	92	2	2	NUM
aiua-13318	30	93	urology	urology	NOUN
aiua-13318	30	94	department	department	NOUN
aiua-13318	30	95	,	,	PUNCT
aiua-13318	30	96	faculty	faculty	NOUN
aiua-13318	30	97	of	of	ADP
aiua-13318	30	98	medicine	medicine	NOUN
aiua-13318	30	99	universitas	universita	NOUN
aiua-13318	30	100	brawijaya	brawijaya	PROPN
aiua-13318	30	101	,	,	PUNCT
aiua-13318	30	102	dr	dr	PROPN
aiua-13318	30	103	.	.	PROPN
aiua-13318	30	104	saiful	saiful	PROPN
aiua-13318	30	105	anwar	anwar	PROPN
aiua-13318	30	106	general	general	PROPN
aiua-13318	30	107	hospital	hospital	PROPN
aiua-13318	30	108	,	,	PUNCT
aiua-13318	30	109	malang	malang	PROPN
aiua-13318	30	110	,	,	PUNCT
aiua-13318	30	111	indonesia	indonesia	PROPN
aiua-13318	30	112	.	.	PUNCT
aiua-13318	31	1	doi	doi	PROPN
aiua-13318	31	2	:	:	PUNCT
aiua-13318	31	3	10.4081	10.4081	NUM
aiua-13318	31	4	/	/	SYM
aiua-13318	31	5	aiua.2025.13318	aiua.2025.13318	PROPN
aiua-13318	31	6	summary	summary	NOUN
aiua-13318	31	7	archivio	archivio	NOUN
aiua-13318	31	8	italiano	italiano	X
aiua-13318	31	9	di	di	X
aiua-13318	31	10	urologia	urologia	PROPN
aiua-13318	31	11	e	e	PROPN
aiua-13318	31	12	andrologia	andrologia	NOUN
aiua-13318	31	13	2025	2025	NUM
aiua-13318	31	14	;	;	PUNCT
aiua-13318	31	15	97(1):13318	97(1):13318	PROPN
aiua-13318	31	16	r.	r.	PROPN
aiua-13318	31	17	maharani	maharani	PROPN
aiua-13318	31	18	,	,	PUNCT
aiua-13318	31	19	h.	h.	PROPN
aiua-13318	31	20	lestari	lestari	PROPN
aiua-13318	31	21	,	,	PUNCT
aiua-13318	31	22	p.	p.	PROPN
aiua-13318	31	23	mahakarya	mahakarya	PROPN
aiua-13318	31	24	dewa	dewa	PROPN
aiua-13318	31	25	,	,	PUNCT
aiua-13318	31	26	et	et	PROPN
aiua-13318	31	27	al	al	PROPN
aiua-13318	31	28	.	.	PROPN
aiua-13318	31	29	2	2	NUM
aiua-13318	31	30	carcinogenesis	carcinogenesis	NOUN
aiua-13318	31	31	(	(	PUNCT
aiua-13318	31	32	8)	8)	NUM
aiua-13318	31	33	.	.	PUNCT
aiua-13318	32	1	in	in	ADP
aiua-13318	32	2	addition	addition	NOUN
aiua-13318	32	3	to	to	ADP
aiua-13318	32	4	the	the	DET
aiua-13318	32	5	v89l	v89l	PROPN
aiua-13318	32	6	polymorphism	polymorphism	NOUN
aiua-13318	32	7	,	,	PUNCT
aiua-13318	32	8	the	the	DET
aiua-13318	32	9	srd5a2	srd5a2	NOUN
aiua-13318	32	10	a49	a49	PROPN
aiua-13318	32	11	t	t	PROPN
aiua-13318	32	12	is	be	AUX
aiua-13318	32	13	linked	link	VERB
aiua-13318	32	14	to	to	ADP
aiua-13318	32	15	a	a	DET
aiua-13318	32	16	significantly	significantly	ADV
aiua-13318	32	17	lower	low	ADJ
aiua-13318	32	18	concentration	concentration	NOUN
aiua-13318	32	19	of	of	ADP
aiua-13318	32	20	androstanediol	androstanediol	PROPN
aiua-13318	32	21	glucuronide	glucuronide	NOUN
aiua-13318	32	22	,	,	PUNCT
aiua-13318	32	23	indicating	indicate	VERB
aiua-13318	32	24	its	its	PRON
aiua-13318	32	25	impact	impact	NOUN
aiua-13318	32	26	on	on	ADP
aiua-13318	32	27	androgen	androgen	NOUN
aiua-13318	32	28	metabolism	metabolism	NOUN
aiua-13318	32	29	(	(	PUNCT
aiua-13318	32	30	9	9	NUM
aiua-13318	32	31	)	)	PUNCT
aiua-13318	32	32	.	.	PUNCT
aiua-13318	33	1	the	the	DET
aiua-13318	33	2	srd5a2	srd5a2	NOUN
aiua-13318	33	3	polymorphism	polymorphism	NOUN
aiua-13318	33	4	likely	likely	ADV
aiua-13318	33	5	represents	represent	VERB
aiua-13318	33	6	a	a	DET
aiua-13318	33	7	crucial	crucial	ADJ
aiua-13318	33	8	point	point	NOUN
aiua-13318	33	9	in	in	ADP
aiua-13318	33	10	dht	dht	ADJ
aiua-13318	33	11	metabolism	metabolism	NOUN
aiua-13318	33	12	,	,	PUNCT
aiua-13318	33	13	possibly	possibly	ADV
aiua-13318	33	14	explaining	explain	VERB
aiua-13318	33	15	its	its	PRON
aiua-13318	33	16	association	association	NOUN
aiua-13318	33	17	with	with	ADP
aiua-13318	33	18	prostate	prostate	NOUN
aiua-13318	33	19	cancer	cancer	NOUN
aiua-13318	33	20	risk	risk	NOUN
aiua-13318	33	21	.	.	PUNCT
aiua-13318	34	1	this	this	PRON
aiua-13318	34	2	underscores	underscore	VERB
aiua-13318	34	3	the	the	DET
aiua-13318	34	4	complexity	complexity	NOUN
aiua-13318	34	5	of	of	ADP
aiua-13318	34	6	genetic	genetic	ADJ
aiua-13318	34	7	factors	factor	NOUN
aiua-13318	34	8	influencing	influence	VERB
aiua-13318	34	9	prostate	prostate	NOUN
aiua-13318	34	10	cancer	cancer	NOUN
aiua-13318	34	11	susceptibility	susceptibility	NOUN
aiua-13318	34	12	.	.	PUNCT
aiua-13318	35	1	both	both	DET
aiua-13318	35	2	polymorphisms	polymorphism	NOUN
aiua-13318	35	3	likely	likely	ADV
aiua-13318	35	4	contribute	contribute	VERB
aiua-13318	35	5	to	to	ADP
aiua-13318	35	6	variations	variation	NOUN
aiua-13318	35	7	in	in	ADP
aiua-13318	35	8	androgen	androgen	NOUN
aiua-13318	35	9	levels	level	NOUN
aiua-13318	35	10	,	,	PUNCT
aiua-13318	35	11	potentially	potentially	ADV
aiua-13318	35	12	influencing	influence	VERB
aiua-13318	35	13	prostate	prostate	NOUN
aiua-13318	35	14	cancer	cancer	NOUN
aiua-13318	35	15	development	development	NOUN
aiua-13318	35	16	(	(	PUNCT
aiua-13318	35	17	10	10	NUM
aiua-13318	35	18	)	)	PUNCT
aiua-13318	35	19	.	.	PUNCT
aiua-13318	36	1	to	to	ADP
aiua-13318	36	2	the	the	DET
aiua-13318	36	3	best	good	ADJ
aiua-13318	36	4	of	of	ADP
aiua-13318	36	5	our	our	PRON
aiua-13318	36	6	knowledge	knowledge	NOUN
aiua-13318	36	7	,	,	PUNCT
aiua-13318	36	8	there	there	PRON
aiua-13318	36	9	has	have	AUX
aiua-13318	36	10	been	be	AUX
aiua-13318	36	11	limited	limit	VERB
aiua-13318	36	12	research	research	NOUN
aiua-13318	36	13	about	about	ADP
aiua-13318	36	14	a49	a49	PROPN
aiua-13318	36	15	t	t	PROPN
aiua-13318	36	16	and	and	CCONJ
aiua-13318	36	17	v89l	v89l	PUNCT
aiua-13318	36	18	polymorphisms	polymorphism	NOUN
aiua-13318	36	19	of	of	ADP
aiua-13318	36	20	srd5ar2	srd5ar2	PROPN
aiua-13318	36	21	as	as	ADP
aiua-13318	36	22	bph	bph	NOUN
aiua-13318	36	23	risk	risk	NOUN
aiua-13318	36	24	factor	factor	NOUN
aiua-13318	36	25	.	.	PUNCT
aiua-13318	37	1	considering	consider	VERB
aiua-13318	37	2	the	the	DET
aiua-13318	37	3	role	role	NOUN
aiua-13318	37	4	in	in	ADP
aiua-13318	37	5	benign	benign	ADJ
aiua-13318	37	6	prostatic	prostatic	ADJ
aiua-13318	37	7	hyperplasia	hyperplasia	NOUN
aiua-13318	37	8	and	and	CCONJ
aiua-13318	37	9	in	in	ADP
aiua-13318	37	10	the	the	DET
aiua-13318	37	11	risk	risk	NOUN
aiua-13318	37	12	of	of	ADP
aiua-13318	37	13	malignancy	malignancy	NOUN
aiua-13318	37	14	and	and	CCONJ
aiua-13318	37	15	in	in	ADP
aiua-13318	37	16	their	their	PRON
aiua-13318	37	17	treatment	treatment	NOUN
aiua-13318	37	18	,	,	PUNCT
aiua-13318	37	19	the	the	DET
aiua-13318	37	20	authors	author	NOUN
aiua-13318	37	21	were	be	AUX
aiua-13318	37	22	interested	interested	ADJ
aiua-13318	37	23	in	in	ADP
aiua-13318	37	24	reviewing	review	VERB
aiua-13318	37	25	evidence	evidence	NOUN
aiua-13318	37	26	about	about	ADP
aiua-13318	37	27	srd5ar2	srd5ar2	PROPN
aiua-13318	37	28	polymorphisms	polymorphisms	PROPN
aiua-13318	37	29	a49	a49	PROPN
aiua-13318	37	30	t	t	PROPN
aiua-13318	37	31	and	and	CCONJ
aiua-13318	37	32	v89l	v89l	VERB
aiua-13318	37	33	,	,	PUNCT
aiua-13318	37	34	in	in	ADP
aiua-13318	37	35	order	order	NOUN
aiua-13318	37	36	to	to	PART
aiua-13318	37	37	assess	assess	VERB
aiua-13318	37	38	their	their	PRON
aiua-13318	37	39	roles	role	NOUN
aiua-13318	37	40	as	as	ADP
aiua-13318	37	41	prognostic	prognostic	ADJ
aiua-13318	37	42	indicators	indicator	NOUN
aiua-13318	37	43	for	for	ADP
aiua-13318	37	44	malignancy	malignancy	NOUN
aiua-13318	37	45	and	and	CCONJ
aiua-13318	37	46	response	response	NOUN
aiua-13318	37	47	to	to	ADP
aiua-13318	37	48	medication	medication	NOUN
aiua-13318	37	49	.	.	PUNCT
aiua-13318	38	1	materials	material	NOUN
aiua-13318	38	2	and	and	CCONJ
aiua-13318	38	3	methods	method	NOUN
aiua-13318	38	4	data	datum	NOUN
aiua-13318	38	5	sources	source	NOUN
aiua-13318	38	6	and	and	CCONJ
aiua-13318	38	7	search	search	NOUN
aiua-13318	38	8	strategy	strategy	NOUN
aiua-13318	38	9	the	the	DET
aiua-13318	38	10	systematic	systematic	ADJ
aiua-13318	38	11	review	review	NOUN
aiua-13318	38	12	was	be	AUX
aiua-13318	38	13	carried	carry	VERB
aiua-13318	38	14	out	out	ADP
aiua-13318	38	15	based	base	VERB
aiua-13318	38	16	on	on	ADP
aiua-13318	38	17	the	the	DET
aiua-13318	38	18	preferred	preferred	ADJ
aiua-13318	38	19	reporting	reporting	NOUN
aiua-13318	38	20	items	item	NOUN
aiua-13318	38	21	for	for	ADP
aiua-13318	38	22	systematic	systematic	ADJ
aiua-13318	38	23	reviews	review	NOUN
aiua-13318	38	24	and	and	CCONJ
aiua-13318	38	25	meta	meta	VERB
aiua-13318	38	26	analysis	analysis	NOUN
aiua-13318	38	27	(	(	PUNCT
aiua-13318	38	28	prisma	prisma	NOUN
aiua-13318	38	29	)	)	PUNCT
aiua-13318	38	30	guidelines	guideline	NOUN
aiua-13318	38	31	by	by	ADP
aiua-13318	38	32	utilizing	utilize	VERB
aiua-13318	38	33	the	the	DET
aiua-13318	38	34	pubmed	pubmed	PROPN
aiua-13318	38	35	,	,	PUNCT
aiua-13318	38	36	scopus	scopus	PROPN
aiua-13318	38	37	,	,	PUNCT
aiua-13318	38	38	wiley	wiley	NOUN
aiua-13318	38	39	,	,	PUNCT
aiua-13318	38	40	proquest	proquest	PROPN
aiua-13318	38	41	,	,	PUNCT
aiua-13318	38	42	cochrane	cochrane	PROPN
aiua-13318	38	43	central	central	NOUN
aiua-13318	38	44	,	,	PUNCT
aiua-13318	38	45	and	and	CCONJ
aiua-13318	38	46	science	science	NOUN
aiua-13318	38	47	direct	direct	ADJ
aiua-13318	38	48	.	.	PUNCT
aiua-13318	39	1	article	article	NOUN
aiua-13318	39	2	search	search	VERB
aiua-13318	39	3	for	for	ADP
aiua-13318	39	4	papers	paper	NOUN
aiua-13318	39	5	in	in	ADP
aiua-13318	39	6	english	english	PROPN
aiua-13318	39	7	was	be	AUX
aiua-13318	39	8	done	do	VERB
aiua-13318	39	9	using	use	VERB
aiua-13318	39	10	boolean	boolean	ADJ
aiua-13318	39	11	operators	operator	NOUN
aiua-13318	39	12	with	with	ADP
aiua-13318	39	13	the	the	DET
aiua-13318	39	14	following	follow	VERB
aiua-13318	39	15	keywords	keyword	NOUN
aiua-13318	39	16	:	:	PUNCT
aiua-13318	40	1	[	[	X
aiua-13318	40	2	(	(	PUNCT
aiua-13318	40	3	benign	benign	ADJ
aiua-13318	40	4	prostatic	prostatic	ADJ
aiua-13318	40	5	hyperplasia	hyperplasia	NOUN
aiua-13318	40	6	)	)	PUNCT
aiua-13318	40	7	or	or	CCONJ
aiua-13318	40	8	(	(	PUNCT
aiua-13318	40	9	bph	bph	NOUN
aiua-13318	40	10	)	)	PUNCT
aiua-13318	40	11	or	or	CCONJ
aiua-13318	40	12	(	(	PUNCT
aiua-13318	40	13	prostate	prostate	NOUN
aiua-13318	40	14	cancer	cancer	NOUN
aiua-13318	40	15	)	)	PUNCT
aiua-13318	40	16	]	]	PUNCT
aiua-13318	40	17	and	and	CCONJ
aiua-13318	40	18	[	[	X
aiua-13318	40	19	(	(	PUNCT
aiua-13318	40	20	rs523349	rs523349	NOUN
aiua-13318	40	21	or	or	CCONJ
aiua-13318	40	22	v89l	v89l	PROPN
aiua-13318	40	23	)	)	PUNCT
aiua-13318	40	24	and	and	CCONJ
aiua-13318	40	25	(	(	PUNCT
aiua-13318	40	26	rs9282858	rs9282858	NOUN
aiua-13318	40	27	or	or	CCONJ
aiua-13318	40	28	a49	a49	PROPN
aiua-13318	40	29	t	t	PROPN
aiua-13318	40	30	)	)	PUNCT
aiua-13318	40	31	]	]	PUNCT
aiua-13318	40	32	.	.	PUNCT
aiua-13318	41	1	the	the	DET
aiua-13318	41	2	inclusion	inclusion	NOUN
aiua-13318	41	3	criteria	criterion	NOUN
aiua-13318	41	4	were	be	AUX
aiua-13318	41	5	:	:	PUNCT
aiua-13318	41	6	case	case	NOUN
aiua-13318	41	7	-	-	PUNCT
aiua-13318	41	8	control	control	NOUN
aiua-13318	41	9	or	or	CCONJ
aiua-13318	41	10	cohort	cohort	NOUN
aiua-13318	41	11	study	study	NOUN
aiua-13318	41	12	;	;	PUNCT
aiua-13318	41	13	study	study	NOUN
aiua-13318	41	14	investigating	investigate	VERB
aiua-13318	41	15	gene	gene	NOUN
aiua-13318	41	16	polymorphisms	polymorphism	NOUN
aiua-13318	41	17	a49	a49	PROPN
aiua-13318	41	18	t	t	PROPN
aiua-13318	41	19	and	and	CCONJ
aiua-13318	41	20	v89l	v89l	PROPN
aiua-13318	41	21	in	in	ADP
aiua-13318	41	22	srd5ar2	srd5ar2	PROPN
aiua-13318	41	23	and	and	CCONJ
aiua-13318	41	24	their	their	PRON
aiua-13318	41	25	association	association	NOUN
aiua-13318	41	26	with	with	ADP
aiua-13318	41	27	bph	bph	NOUN
aiua-13318	41	28	and	and	CCONJ
aiua-13318	41	29	prostate	prostate	NOUN
aiua-13318	41	30	cancer	cancer	NOUN
aiua-13318	41	31	;	;	PUNCT
aiua-13318	41	32	written	write	VERB
aiua-13318	41	33	in	in	ADP
aiua-13318	41	34	english	english	PROPN
aiua-13318	41	35	.	.	PUNCT
aiua-13318	42	1	quality	quality	NOUN
aiua-13318	42	2	appraisal	appraisal	NOUN
aiua-13318	42	3	of	of	ADP
aiua-13318	42	4	clinical	clinical	ADJ
aiua-13318	42	5	trials	trial	NOUN
aiua-13318	42	6	was	be	AUX
aiua-13318	42	7	evaluated	evaluate	VERB
aiua-13318	42	8	using	use	VERB
aiua-13318	42	9	the	the	DET
aiua-13318	42	10	joanna	joanna	PROPN
aiua-13318	42	11	briggs	briggs	PROPN
aiua-13318	42	12	institute	institute	PROPN
aiua-13318	42	13	approach	approach	PROPN
aiua-13318	42	14	for	for	ADP
aiua-13318	42	15	systematic	systematic	ADJ
aiua-13318	42	16	reviews	review	NOUN
aiua-13318	42	17	.	.	PUNCT
aiua-13318	43	1	selection	selection	NOUN
aiua-13318	43	2	process	process	NOUN
aiua-13318	43	3	the	the	DET
aiua-13318	43	4	authors	author	NOUN
aiua-13318	43	5	individually	individually	ADV
aiua-13318	43	6	evaluated	evaluate	VERB
aiua-13318	43	7	findings	finding	NOUN
aiua-13318	43	8	of	of	ADP
aiua-13318	43	9	literature	literature	NOUN
aiua-13318	43	10	search	search	NOUN
aiua-13318	43	11	,	,	PUNCT
aiua-13318	43	12	beginning	begin	VERB
aiua-13318	43	13	with	with	ADP
aiua-13318	43	14	the	the	DET
aiua-13318	43	15	titles	title	NOUN
aiua-13318	43	16	and	and	CCONJ
aiua-13318	43	17	abstracts	abstract	NOUN
aiua-13318	43	18	of	of	ADP
aiua-13318	43	19	papers	paper	NOUN
aiua-13318	43	20	which	which	PRON
aiua-13318	43	21	passed	pass	VERB
aiua-13318	43	22	eligibility	eligibility	NOUN
aiua-13318	43	23	criteria	criterion	NOUN
aiua-13318	43	24	screening	screen	VERB
aiua-13318	43	25	.	.	PUNCT
aiua-13318	44	1	any	any	DET
aiua-13318	44	2	disagreement	disagreement	NOUN
aiua-13318	44	3	was	be	AUX
aiua-13318	44	4	freely	freely	ADV
aiua-13318	44	5	discussed	discuss	VERB
aiua-13318	44	6	with	with	ADP
aiua-13318	44	7	one	one	NUM
aiua-13318	44	8	senior	senior	ADJ
aiua-13318	44	9	author	author	NOUN
aiua-13318	44	10	to	to	PART
aiua-13318	44	11	settle	settle	VERB
aiua-13318	44	12	them	they	PRON
aiua-13318	44	13	.	.	PUNCT
aiua-13318	45	1	the	the	DET
aiua-13318	45	2	entire	entire	ADJ
aiua-13318	45	3	text	text	NOUN
aiua-13318	45	4	was	be	AUX
aiua-13318	45	5	then	then	ADV
aiua-13318	45	6	examined	examine	VERB
aiua-13318	45	7	to	to	PART
aiua-13318	45	8	weed	weed	VERB
aiua-13318	45	9	out	out	ADP
aiua-13318	45	10	research	research	NOUN
aiua-13318	45	11	that	that	PRON
aiua-13318	45	12	were	be	AUX
aiua-13318	45	13	not	not	PART
aiua-13318	45	14	relevant	relevant	ADJ
aiua-13318	45	15	.	.	PUNCT
aiua-13318	46	1	data	datum	NOUN
aiua-13318	46	2	extraction	extraction	NOUN
aiua-13318	46	3	the	the	DET
aiua-13318	46	4	selected	select	VERB
aiua-13318	46	5	articles	article	NOUN
aiua-13318	46	6	were	be	AUX
aiua-13318	46	7	extracted	extract	VERB
aiua-13318	46	8	by	by	ADP
aiua-13318	46	9	the	the	DET
aiua-13318	46	10	authors	author	NOUN
aiua-13318	46	11	,	,	PUNCT
aiua-13318	46	12	who	who	PRON
aiua-13318	46	13	then	then	ADV
aiua-13318	46	14	assessed	assess	VERB
aiua-13318	46	15	their	their	PRON
aiua-13318	46	16	suitability	suitability	NOUN
aiua-13318	46	17	.	.	PUNCT
aiua-13318	47	1	disagreements	disagreement	NOUN
aiua-13318	47	2	were	be	AUX
aiua-13318	47	3	discussed	discuss	VERB
aiua-13318	47	4	and	and	CCONJ
aiua-13318	47	5	ultimately	ultimately	ADV
aiua-13318	47	6	settled	settle	VERB
aiua-13318	47	7	after	after	SCONJ
aiua-13318	47	8	each	each	DET
aiua-13318	47	9	author	author	NOUN
aiua-13318	47	10	reviewed	review	VERB
aiua-13318	47	11	the	the	DET
aiua-13318	47	12	articles	article	NOUN
aiua-13318	47	13	on	on	ADP
aiua-13318	47	14	his	his	PRON
aiua-13318	47	15	own	own	ADJ
aiua-13318	47	16	.	.	PUNCT
aiua-13318	48	1	name	name	NOUN
aiua-13318	48	2	of	of	ADP
aiua-13318	48	3	the	the	DET
aiua-13318	48	4	author	author	NOUN
aiua-13318	48	5	,	,	PUNCT
aiua-13318	48	6	year	year	NOUN
aiua-13318	48	7	of	of	ADP
aiua-13318	48	8	publication	publication	NOUN
aiua-13318	48	9	,	,	PUNCT
aiua-13318	48	10	country	country	NOUN
aiua-13318	48	11	,	,	PUNCT
aiua-13318	48	12	study	study	NOUN
aiua-13318	48	13	design	design	NOUN
aiua-13318	48	14	,	,	PUNCT
aiua-13318	48	15	number	number	NOUN
aiua-13318	48	16	of	of	ADP
aiua-13318	48	17	samples	sample	NOUN
aiua-13318	48	18	,	,	PUNCT
aiua-13318	48	19	sample	sample	NOUN
aiua-13318	48	20	characteristics	characteristic	NOUN
aiua-13318	48	21	,	,	PUNCT
aiua-13318	48	22	intervention	intervention	NOUN
aiua-13318	48	23	,	,	PUNCT
aiua-13318	48	24	comparison	comparison	NOUN
aiua-13318	48	25	,	,	PUNCT
aiua-13318	48	26	length	length	NOUN
aiua-13318	48	27	of	of	ADP
aiua-13318	48	28	followup	followup	NOUN
aiua-13318	48	29	,	,	PUNCT
aiua-13318	48	30	and	and	CCONJ
aiua-13318	48	31	desired	desire	VERB
aiua-13318	48	32	outcomes	outcome	NOUN
aiua-13318	48	33	were	be	AUX
aiua-13318	48	34	taken	take	VERB
aiua-13318	48	35	from	from	ADP
aiua-13318	48	36	eligible	eligible	ADJ
aiua-13318	48	37	studies	study	NOUN
aiua-13318	48	38	.	.	PUNCT
aiua-13318	49	1	results	result	NOUN
aiua-13318	49	2	study	study	VERB
aiua-13318	49	3	selection	selection	NOUN
aiua-13318	49	4	after	after	ADP
aiua-13318	49	5	the	the	DET
aiua-13318	49	6	literature	literature	NOUN
aiua-13318	49	7	search	search	NOUN
aiua-13318	49	8	,	,	PUNCT
aiua-13318	49	9	116	116	NUM
aiua-13318	49	10	articles	article	NOUN
aiua-13318	49	11	were	be	AUX
aiua-13318	49	12	retrieved	retrieve	VERB
aiua-13318	49	13	by	by	ADP
aiua-13318	49	14	the	the	DET
aiua-13318	49	15	six	six	NUM
aiua-13318	49	16	databases	database	NOUN
aiua-13318	49	17	.	.	PUNCT
aiua-13318	50	1	several	several	ADJ
aiua-13318	50	2	articles	article	NOUN
aiua-13318	50	3	were	be	AUX
aiua-13318	50	4	excluded	exclude	VERB
aiua-13318	50	5	due	due	ADP
aiua-13318	50	6	to	to	ADP
aiua-13318	50	7	duplication	duplication	NOUN
aiua-13318	50	8	of	of	ADP
aiua-13318	50	9	studies	study	NOUN
aiua-13318	50	10	(	(	PUNCT
aiua-13318	50	11	n	n	NOUN
aiua-13318	50	12	=	=	NUM
aiua-13318	50	13	29	29	NUM
aiua-13318	50	14	)	)	PUNCT
aiua-13318	50	15	.	.	PUNCT
aiua-13318	51	1	some	some	DET
aiua-13318	51	2	papers	paper	NOUN
aiua-13318	51	3	were	be	AUX
aiua-13318	51	4	excluded	exclude	VERB
aiua-13318	51	5	because	because	SCONJ
aiua-13318	51	6	they	they	PRON
aiua-13318	51	7	did	do	AUX
aiua-13318	51	8	not	not	PART
aiua-13318	51	9	adhere	adhere	VERB
aiua-13318	51	10	to	to	ADP
aiua-13318	51	11	inclusion	inclusion	NOUN
aiua-13318	51	12	criteria	criterion	NOUN
aiua-13318	51	13	(	(	PUNCT
aiua-13318	51	14	n	n	NOUN
aiua-13318	51	15	=	=	SYM
aiua-13318	51	16	36	36	NUM
aiua-13318	51	17	)	)	PUNCT
aiua-13318	51	18	.	.	PUNCT
aiua-13318	52	1	there	there	PRON
aiua-13318	52	2	were	be	VERB
aiua-13318	52	3	41	41	NUM
aiua-13318	52	4	articles	article	NOUN
aiua-13318	52	5	excluded	exclude	VERB
aiua-13318	52	6	due	due	ADP
aiua-13318	52	7	to	to	ADP
aiua-13318	52	8	ineligible	ineligible	ADJ
aiua-13318	52	9	data	datum	NOUN
aiua-13318	52	10	,	,	PUNCT
aiua-13318	52	11	such	such	ADJ
aiua-13318	52	12	as	as	ADP
aiua-13318	52	13	review	review	NOUN
aiua-13318	52	14	articles	article	NOUN
aiua-13318	52	15	and	and	CCONJ
aiua-13318	52	16	books	book	NOUN
aiua-13318	52	17	,	,	PUNCT
aiua-13318	52	18	and	and	CCONJ
aiua-13318	52	19	inaccessible	inaccessible	ADJ
aiua-13318	52	20	articles	article	NOUN
aiua-13318	52	21	due	due	ADP
aiua-13318	52	22	to	to	ADP
aiua-13318	52	23	subscriptions	subscription	NOUN
aiua-13318	52	24	.	.	PUNCT
aiua-13318	53	1	finally	finally	ADV
aiua-13318	53	2	,	,	PUNCT
aiua-13318	53	3	nine	nine	NUM
aiua-13318	53	4	articles	article	NOUN
aiua-13318	53	5	were	be	AUX
aiua-13318	53	6	included	include	VERB
aiua-13318	53	7	in	in	ADP
aiua-13318	53	8	the	the	DET
aiua-13318	53	9	systematic	systematic	ADJ
aiua-13318	53	10	review	review	NOUN
aiua-13318	53	11	to	to	PART
aiua-13318	53	12	be	be	AUX
aiua-13318	53	13	analysed	analyse	VERB
aiua-13318	53	14	qualitatively	qualitatively	ADV
aiua-13318	53	15	and	and	CCONJ
aiua-13318	53	16	quantitatively	quantitatively	ADV
aiua-13318	53	17	.	.	PUNCT
aiua-13318	54	1	figure	figure	NOUN
aiua-13318	54	2	1	1	NUM
aiua-13318	54	3	shows	show	VERB
aiua-13318	54	4	the	the	DET
aiua-13318	54	5	prisma	prisma	PROPN
aiua-13318	54	6	flowchart	flowchart	PROPN
aiua-13318	54	7	.	.	PUNCT
aiua-13318	55	1	study	study	NOUN
aiua-13318	55	2	design	design	NOUN
aiua-13318	55	3	this	this	DET
aiua-13318	55	4	review	review	NOUN
aiua-13318	55	5	consists	consist	VERB
aiua-13318	55	6	of	of	ADP
aiua-13318	55	7	9	9	NUM
aiua-13318	55	8	clinical	clinical	ADJ
aiua-13318	55	9	studies	study	NOUN
aiua-13318	55	10	with	with	ADP
aiua-13318	55	11	varying	vary	VERB
aiua-13318	55	12	designs	design	NOUN
aiua-13318	55	13	:	:	PUNCT
aiua-13318	55	14	1	1	NUM
aiua-13318	55	15	cross	cross	ADJ
aiua-13318	55	16	-	-	ADJ
aiua-13318	55	17	sectional	sectional	ADJ
aiua-13318	55	18	,	,	PUNCT
aiua-13318	55	19	3	3	NUM
aiua-13318	55	20	case	case	NOUN
aiua-13318	55	21	-	-	PUNCT
aiua-13318	55	22	control	control	NOUN
aiua-13318	55	23	,	,	PUNCT
aiua-13318	55	24	2	2	NUM
aiua-13318	55	25	cohort	cohort	NOUN
aiua-13318	55	26	studies	study	NOUN
aiua-13318	55	27	,	,	PUNCT
aiua-13318	55	28	and	and	CCONJ
aiua-13318	55	29	3	3	NUM
aiua-13318	55	30	clinical	clinical	ADJ
aiua-13318	55	31	trials	trial	NOUN
aiua-13318	55	32	.	.	PUNCT
aiua-13318	56	1	the	the	DET
aiua-13318	56	2	total	total	ADJ
aiua-13318	56	3	number	number	NOUN
aiua-13318	56	4	of	of	ADP
aiua-13318	56	5	participants	participant	NOUN
aiua-13318	56	6	across	across	ADP
aiua-13318	56	7	all	all	DET
aiua-13318	56	8	studies	study	NOUN
aiua-13318	56	9	includes	include	VERB
aiua-13318	56	10	1,226	1,226	NUM
aiua-13318	56	11	individuals	individual	NOUN
aiua-13318	56	12	,	,	PUNCT
aiua-13318	56	13	comprising	comprise	VERB
aiua-13318	56	14	prostate	prostate	NOUN
aiua-13318	56	15	cancer	cancer	NOUN
aiua-13318	56	16	patients	patient	NOUN
aiua-13318	56	17	,	,	PUNCT
aiua-13318	56	18	bph	bph	NOUN
aiua-13318	56	19	patients	patient	NOUN
aiua-13318	56	20	,	,	PUNCT
aiua-13318	56	21	and	and	CCONJ
aiua-13318	56	22	healthy	healthy	ADJ
aiua-13318	56	23	controls	control	NOUN
aiua-13318	56	24	.	.	PUNCT
aiua-13318	57	1	methods	method	NOUN
aiua-13318	57	2	of	of	ADP
aiua-13318	57	3	diagnosis	diagnosis	NOUN
aiua-13318	57	4	and	and	CCONJ
aiua-13318	57	5	assessment	assessment	NOUN
aiua-13318	57	6	included	include	VERB
aiua-13318	57	7	blood	blood	NOUN
aiua-13318	57	8	diagnostic	diagnostic	ADJ
aiua-13318	57	9	criteria	criterion	NOUN
aiua-13318	57	10	,	,	PUNCT
aiua-13318	57	11	prostate	prostate	NOUN
aiua-13318	57	12	-	-	PUNCT
aiua-13318	57	13	specific	specific	ADJ
aiua-13318	57	14	antigen	antigen	NOUN
aiua-13318	57	15	(	(	PUNCT
aiua-13318	57	16	psa	psa	NOUN
aiua-13318	57	17	)	)	PUNCT
aiua-13318	57	18	testing	testing	NOUN
aiua-13318	57	19	,	,	PUNCT
aiua-13318	57	20	digital	digital	ADJ
aiua-13318	57	21	rectal	rectal	ADJ
aiua-13318	57	22	examination	examination	NOUN
aiua-13318	57	23	(	(	PUNCT
aiua-13318	57	24	dre	dre	NOUN
aiua-13318	57	25	)	)	PUNCT
aiua-13318	57	26	,	,	PUNCT
aiua-13318	57	27	and	and	CCONJ
aiua-13318	57	28	biopsy	biopsy	NOUN
aiua-13318	57	29	results	result	NOUN
aiua-13318	57	30	.	.	PUNCT
aiua-13318	58	1	the	the	DET
aiua-13318	58	2	geographic	geographic	ADJ
aiua-13318	58	3	distribution	distribution	NOUN
aiua-13318	58	4	of	of	ADP
aiua-13318	58	5	the	the	DET
aiua-13318	58	6	studies	study	NOUN
aiua-13318	58	7	includes	include	VERB
aiua-13318	58	8	bulgaria	bulgaria	PROPN
aiua-13318	58	9	,	,	PUNCT
aiua-13318	58	10	china	china	PROPN
aiua-13318	58	11	,	,	PUNCT
aiua-13318	58	12	japan	japan	PROPN
aiua-13318	58	13	,	,	PUNCT
aiua-13318	58	14	the	the	DET
aiua-13318	58	15	usa	usa	PROPN
aiua-13318	58	16	,	,	PUNCT
aiua-13318	58	17	india	india	PROPN
aiua-13318	58	18	,	,	PUNCT
aiua-13318	58	19	and	and	CCONJ
aiua-13318	58	20	sweden	sweden	PROPN
aiua-13318	58	21	.	.	PUNCT
aiua-13318	59	1	the	the	DET
aiua-13318	59	2	review	review	NOUN
aiua-13318	59	3	emphasizes	emphasize	VERB
aiua-13318	59	4	the	the	DET
aiua-13318	59	5	impact	impact	NOUN
aiua-13318	59	6	of	of	ADP
aiua-13318	59	7	gene	gene	NOUN
aiua-13318	59	8	polymorphism	polymorphism	NOUN
aiua-13318	59	9	and	and	CCONJ
aiua-13318	59	10	its	its	PRON
aiua-13318	59	11	associations	association	NOUN
aiua-13318	59	12	with	with	ADP
aiua-13318	59	13	prostate	prostate	NOUN
aiua-13318	59	14	diseases	disease	NOUN
aiua-13318	59	15	,	,	PUNCT
aiua-13318	59	16	explores	explore	NOUN
aiua-13318	59	17	and	and	CCONJ
aiua-13318	59	18	discusses	discuss	VERB
aiua-13318	59	19	their	their	PRON
aiua-13318	59	20	implications	implication	NOUN
aiua-13318	59	21	for	for	ADP
aiua-13318	59	22	personalized	personalized	ADJ
aiua-13318	59	23	medicine	medicine	NOUN
aiua-13318	59	24	.	.	PUNCT
aiua-13318	60	1	risk	risk	NOUN
aiua-13318	60	2	of	of	ADP
aiua-13318	60	3	bias	bias	NOUN
aiua-13318	60	4	summary	summary	VERB
aiua-13318	60	5	the	the	DET
aiua-13318	60	6	risk	risk	NOUN
aiua-13318	60	7	of	of	ADP
aiua-13318	60	8	bias	bias	NOUN
aiua-13318	60	9	for	for	ADP
aiua-13318	60	10	various	various	ADJ
aiua-13318	60	11	study	study	NOUN
aiua-13318	60	12	designs	design	NOUN
aiua-13318	60	13	;	;	PUNCT
aiua-13318	60	14	case	case	NOUN
aiua-13318	60	15	-	-	PUNCT
aiua-13318	60	16	control	control	NOUN
aiua-13318	60	17	,	,	PUNCT
aiua-13318	60	18	cohort	cohort	NOUN
aiua-13318	60	19	,	,	PUNCT
aiua-13318	60	20	and	and	CCONJ
aiua-13318	60	21	cross	cross	ADJ
aiua-13318	60	22	-	-	ADJ
aiua-13318	60	23	sectional	sectional	ADJ
aiua-13318	60	24	was	be	AUX
aiua-13318	60	25	evaluated	evaluate	VERB
aiua-13318	60	26	using	use	VERB
aiua-13318	60	27	the	the	DET
aiua-13318	60	28	jbi	jbi	NOUN
aiua-13318	60	29	critical	critical	ADJ
aiua-13318	60	30	appraisal	appraisal	NOUN
aiua-13318	60	31	tools	tool	NOUN
aiua-13318	60	32	.	.	PUNCT
aiua-13318	61	1	according	accord	VERB
aiua-13318	61	2	to	to	ADP
aiua-13318	61	3	the	the	DET
aiua-13318	61	4	risk	risk	NOUN
aiua-13318	61	5	of	of	ADP
aiua-13318	61	6	bias	bias	NOUN
aiua-13318	61	7	assessment	assessment	NOUN
aiua-13318	61	8	,	,	PUNCT
aiua-13318	61	9	three	three	NUM
aiua-13318	61	10	studies	study	NOUN
aiua-13318	61	11	were	be	AUX
aiua-13318	61	12	found	find	VERB
aiua-13318	61	13	to	to	PART
aiua-13318	61	14	have	have	VERB
aiua-13318	61	15	a	a	DET
aiua-13318	61	16	moderate	moderate	ADJ
aiua-13318	61	17	risk	risk	NOUN
aiua-13318	61	18	of	of	ADP
aiua-13318	61	19	bias	bias	NOUN
aiua-13318	61	20	,	,	PUNCT
aiua-13318	61	21	primarily	primarily	ADV
aiua-13318	61	22	due	due	ADJ
aiua-13318	61	23	to	to	ADP
aiua-13318	61	24	ambiguous	ambiguous	ADJ
aiua-13318	61	25	statements	statement	NOUN
aiua-13318	61	26	in	in	ADP
aiua-13318	61	27	areas	area	NOUN
aiua-13318	61	28	such	such	ADJ
aiua-13318	61	29	as	as	ADP
aiua-13318	61	30	the	the	DET
aiua-13318	61	31	identification	identification	NOUN
aiua-13318	61	32	of	of	ADP
aiua-13318	61	33	confounding	confound	VERB
aiua-13318	61	34	factors	factor	NOUN
aiua-13318	61	35	and	and	CCONJ
aiua-13318	61	36	the	the	DET
aiua-13318	61	37	strategies	strategy	NOUN
aiua-13318	61	38	used	use	VERB
aiua-13318	61	39	to	to	PART
aiua-13318	61	40	address	address	VERB
aiua-13318	61	41	them	they	PRON
aiua-13318	61	42	,	,	PUNCT
aiua-13318	61	43	as	as	ADV
aiua-13318	61	44	well	well	ADV
aiua-13318	61	45	as	as	ADP
aiua-13318	61	46	incomplete	incomplete	ADJ
aiua-13318	61	47	data	datum	NOUN
aiua-13318	61	48	throughout	throughout	ADP
aiua-13318	61	49	the	the	DET
aiua-13318	61	50	studies	study	NOUN
aiua-13318	61	51	.	.	PUNCT
aiua-13318	62	1	the	the	DET
aiua-13318	62	2	remaining	remain	VERB
aiua-13318	62	3	studies	study	NOUN
aiua-13318	62	4	(	(	PUNCT
aiua-13318	62	5	n	n	NOUN
aiua-13318	62	6	=	=	SYM
aiua-13318	62	7	6	6	NUM
aiua-13318	62	8	)	)	PUNCT
aiua-13318	62	9	were	be	AUX
aiua-13318	62	10	classified	classify	VERB
aiua-13318	62	11	as	as	ADP
aiua-13318	62	12	having	have	VERB
aiua-13318	62	13	a	a	DET
aiua-13318	62	14	low	low	ADJ
aiua-13318	62	15	risk	risk	NOUN
aiua-13318	62	16	of	of	ADP
aiua-13318	62	17	bias	bias	NOUN
aiua-13318	62	18	(	(	PUNCT
aiua-13318	62	19	see	see	VERB
aiua-13318	62	20	figure	figure	NOUN
aiua-13318	62	21	2	2	NUM
aiua-13318	62	22	)	)	PUNCT
aiua-13318	62	23	.	.	PUNCT
aiua-13318	63	1	despite	despite	SCONJ
aiua-13318	63	2	the	the	DET
aiua-13318	63	3	varying	vary	VERB
aiua-13318	63	4	levels	level	NOUN
aiua-13318	63	5	of	of	ADP
aiua-13318	63	6	bias	bias	NOUN
aiua-13318	63	7	across	across	ADP
aiua-13318	63	8	the	the	DET
aiua-13318	63	9	included	include	VERB
aiua-13318	63	10	studies	study	NOUN
aiua-13318	63	11	,	,	PUNCT
aiua-13318	63	12	most	most	ADJ
aiua-13318	63	13	of	of	ADP
aiua-13318	63	14	the	the	DET
aiua-13318	63	15	data	datum	NOUN
aiua-13318	63	16	have	have	AUX
aiua-13318	63	17	been	be	AUX
aiua-13318	63	18	thoroughly	thoroughly	ADV
aiua-13318	63	19	examined	examine	VERB
aiua-13318	63	20	and	and	CCONJ
aiua-13318	63	21	discussed	discuss	VERB
aiua-13318	63	22	.	.	PUNCT
aiua-13318	64	1	the	the	DET
aiua-13318	64	2	reviewers	reviewer	NOUN
aiua-13318	64	3	concluded	conclude	VERB
aiua-13318	64	4	that	that	SCONJ
aiua-13318	64	5	,	,	PUNCT
aiua-13318	64	6	overall	overall	ADV
aiua-13318	64	7	,	,	PUNCT
aiua-13318	64	8	the	the	DET
aiua-13318	64	9	studies	study	NOUN
aiua-13318	64	10	are	be	AUX
aiua-13318	64	11	sufficiently	sufficiently	ADV
aiua-13318	64	12	suitable	suitable	ADJ
aiua-13318	64	13	for	for	ADP
aiua-13318	64	14	analysis	analysis	NOUN
aiua-13318	64	15	.	.	PUNCT
aiua-13318	65	1	study	study	NOUN
aiua-13318	65	2	result	result	NOUN
aiua-13318	65	3	summary	summary	NOUN
aiua-13318	65	4	gene	gene	NOUN
aiua-13318	65	5	polymorphism	polymorphism	NOUN
aiua-13318	65	6	results	result	VERB
aiua-13318	65	7	for	for	ADP
aiua-13318	65	8	v89l	v89l	NOUN
aiua-13318	65	9	variant	variant	NOUN
aiua-13318	65	10	of	of	ADP
aiua-13318	65	11	srd5a2	srd5a2	NOUN
aiua-13318	65	12	are	be	AUX
aiua-13318	65	13	reported	report	VERB
aiua-13318	65	14	in	in	ADP
aiua-13318	65	15	table	table	NOUN
aiua-13318	65	16	1	1	NUM
aiua-13318	65	17	.	.	PUNCT
aiua-13318	66	1	for	for	ADP
aiua-13318	66	2	the	the	DET
aiua-13318	66	3	a49	a49	PROPN
aiua-13318	66	4	t	t	PROPN
aiua-13318	66	5	,	,	PUNCT
aiua-13318	66	6	men	man	NOUN
aiua-13318	66	7	with	with	ADP
aiua-13318	66	8	the	the	DET
aiua-13318	66	9	at	at	ADP
aiua-13318	66	10	/	/	SYM
aiua-13318	66	11	tt	tt	PROPN
aiua-13318	66	12	genotypes	genotype	NOUN
aiua-13318	66	13	were	be	AUX
aiua-13318	66	14	at	at	ADP
aiua-13318	66	15	increased	increase	VERB
aiua-13318	66	16	risk	risk	NOUN
aiua-13318	66	17	for	for	ADP
aiua-13318	66	18	bph	bph	NOUN
aiua-13318	66	19	,	,	PUNCT
aiua-13318	66	20	asymptomatic	asymptomatic	ADJ
aiua-13318	66	21	,	,	PUNCT
aiua-13318	66	22	and	and	CCONJ
aiua-13318	66	23	symptomatic	symptomatic	ADJ
aiua-13318	66	24	bph	bph	NOUN
aiua-13318	66	25	and	and	CCONJ
aiua-13318	66	26	prostate	prostate	NOUN
aiua-13318	66	27	cancer	cancer	NOUN
aiua-13318	66	28	compared	compare	VERB
aiua-13318	66	29	to	to	ADP
aiua-13318	66	30	men	man	NOUN
aiua-13318	66	31	with	with	ADP
aiua-13318	66	32	the	the	DET
aiua-13318	66	33	aa	aa	PROPN
aiua-13318	66	34	genotype	genotype	NOUN
aiua-13318	66	35	,	,	PUNCT
aiua-13318	66	36	although	although	SCONJ
aiua-13318	66	37	none	none	NOUN
aiua-13318	66	38	of	of	ADP
aiua-13318	66	39	the	the	PRON
aiua-13318	66	40	or	or	CCONJ
aiua-13318	66	41	reached	reach	VERB
aiua-13318	66	42	statistical	statistical	ADJ
aiua-13318	66	43	significance	significance	NOUN
aiua-13318	66	44	.	.	PUNCT
aiua-13318	67	1	association	association	NOUN
aiua-13318	67	2	to	to	ADP
aiua-13318	67	3	malignancy	malignancy	NOUN
aiua-13318	67	4	based	base	VERB
aiua-13318	67	5	on	on	ADP
aiua-13318	67	6	the	the	DET
aiua-13318	67	7	studies	study	NOUN
aiua-13318	67	8	on	on	ADP
aiua-13318	67	9	v89l	v89l	NOUN
aiua-13318	67	10	polymorphism	polymorphism	NOUN
aiua-13318	67	11	that	that	PRON
aiua-13318	67	12	were	be	AUX
aiua-13318	67	13	evaluated	evaluate	VERB
aiua-13318	67	14	,	,	PUNCT
aiua-13318	67	15	it	it	PRON
aiua-13318	67	16	was	be	AUX
aiua-13318	67	17	shown	show	VERB
aiua-13318	67	18	that	that	SCONJ
aiua-13318	67	19	“	"	PUNCT
aiua-13318	67	20	ll	ll	NOUN
aiua-13318	67	21	”	"	PUNCT
aiua-13318	67	22	allele	allele	NOUN
aiua-13318	67	23	,	,	PUNCT
aiua-13318	67	24	that	that	PRON
aiua-13318	67	25	confers	confer	VERB
aiua-13318	67	26	a	a	DET
aiua-13318	67	27	low	low	ADJ
aiua-13318	67	28	activity	activity	NOUN
aiua-13318	67	29	of	of	ADP
aiua-13318	67	30	5	5	NUM
aiua-13318	67	31	alpha	alpha	NOUN
aiua-13318	67	32	reductase	reductase	NOUN
aiua-13318	67	33	,	,	PUNCT
aiua-13318	67	34	was	be	AUX
aiua-13318	67	35	less	less	ADV
aiua-13318	67	36	common	common	ADJ
aiua-13318	67	37	in	in	ADP
aiua-13318	67	38	patients	patient	NOUN
aiua-13318	67	39	with	with	ADP
aiua-13318	67	40	prostate	prostate	NOUN
aiua-13318	67	41	cancer	cancer	NOUN
aiua-13318	67	42	.	.	PUNCT
aiua-13318	68	1	on	on	ADP
aiua-13318	68	2	the	the	DET
aiua-13318	68	3	other	other	ADJ
aiua-13318	68	4	hand	hand	NOUN
aiua-13318	68	5	,	,	PUNCT
aiua-13318	68	6	“	"	PUNCT
aiua-13318	68	7	vv	vv	NOUN
aiua-13318	68	8	”	"	PUNCT
aiua-13318	68	9	locus	locus	NOUN
aiua-13318	68	10	,	,	PUNCT
aiua-13318	68	11	which	which	PRON
aiua-13318	68	12	is	be	AUX
aiua-13318	68	13	commonly	commonly	ADV
aiua-13318	68	14	found	find	VERB
aiua-13318	68	15	in	in	ADP
aiua-13318	68	16	the	the	DET
aiua-13318	68	17	hispanic	hispanic	ADJ
aiua-13318	68	18	population	population	NOUN
aiua-13318	68	19	,	,	PUNCT
aiua-13318	68	20	is	be	AUX
aiua-13318	68	21	associated	associate	VERB
aiua-13318	68	22	with	with	ADP
aiua-13318	68	23	a	a	DET
aiua-13318	68	24	higher	high	ADJ
aiua-13318	68	25	risk	risk	NOUN
aiua-13318	68	26	of	of	ADP
aiua-13318	68	27	bph	bph	NOUN
aiua-13318	68	28	.	.	PUNCT
aiua-13318	69	1	the	the	DET
aiua-13318	69	2	a49	a49	PROPN
aiua-13318	69	3	t	t	PROPN
aiua-13318	69	4	gene	gene	NOUN
aiua-13318	69	5	consists	consist	VERB
aiua-13318	69	6	of	of	ADP
aiua-13318	69	7	“	"	PUNCT
aiua-13318	69	8	aa	aa	NOUN
aiua-13318	69	9	”	"	PUNCT
aiua-13318	69	10	locus	locus	NOUN
aiua-13318	69	11	and	and	CCONJ
aiua-13318	69	12	“	"	PUNCT
aiua-13318	69	13	tt	tt	PROPN
aiua-13318	69	14	”	"	PUNCT
aiua-13318	69	15	locus	locus	NOUN
aiua-13318	69	16	producing	produce	VERB
aiua-13318	69	17	“	"	PUNCT
aiua-13318	69	18	aa	aa	NOUN
aiua-13318	69	19	”	"	PUNCT
aiua-13318	69	20	,	,	PUNCT
aiua-13318	69	21	“	"	PUNCT
aiua-13318	69	22	at	at	ADP
aiua-13318	69	23	”	"	PUNCT
aiua-13318	69	24	,	,	PUNCT
aiua-13318	69	25	and	and	CCONJ
aiua-13318	69	26	“	"	PUNCT
aiua-13318	69	27	tt	tt	PROPN
aiua-13318	69	28	”	"	PUNCT
aiua-13318	69	29	genotypes	genotype	NOUN
aiua-13318	69	30	.	.	PUNCT
aiua-13318	70	1	all	all	PRON
aiua-13318	70	2	of	of	ADP
aiua-13318	70	3	the	the	DET
aiua-13318	70	4	genotypes	genotype	NOUN
aiua-13318	70	5	mentioned	mention	VERB
aiua-13318	70	6	have	have	VERB
aiua-13318	70	7	no	no	DET
aiua-13318	70	8	statistically	statistically	ADV
aiua-13318	70	9	significant	significant	ADJ
aiua-13318	70	10	correlation	correlation	NOUN
aiua-13318	70	11	to	to	ADP
aiua-13318	70	12	malignancy	malignancy	NOUN
aiua-13318	70	13	,	,	PUNCT
aiua-13318	70	14	although	although	SCONJ
aiua-13318	70	15	“	"	PUNCT
aiua-13318	70	16	at	at	ADP
aiua-13318	70	17	”	"	PUNCT
aiua-13318	70	18	and	and	CCONJ
aiua-13318	70	19	“	"	PUNCT
aiua-13318	70	20	tt	tt	PROPN
aiua-13318	70	21	”	"	PUNCT
aiua-13318	70	22	genotypes	genotype	NOUN
aiua-13318	70	23	have	have	VERB
aiua-13318	70	24	a	a	DET
aiua-13318	70	25	higher	high	ADJ
aiua-13318	70	26	risk	risk	NOUN
aiua-13318	70	27	of	of	ADP
aiua-13318	70	28	developing	develop	VERB
aiua-13318	70	29	prostate	prostate	NOUN
aiua-13318	70	30	cancer	cancer	NOUN
aiua-13318	70	31	.	.	PUNCT
aiua-13318	71	1	“	"	PUNCT
aiua-13318	71	2	at	at	ADP
aiua-13318	71	3	”	"	PUNCT
aiua-13318	71	4	archivio	archivio	NOUN
aiua-13318	71	5	italiano	italiano	X
aiua-13318	71	6	di	di	X
aiua-13318	71	7	urologia	urologia	PROPN
aiua-13318	71	8	e	e	PROPN
aiua-13318	71	9	andrologia	andrologia	NOUN
aiua-13318	71	10	2025	2025	NUM
aiua-13318	71	11	;	;	PUNCT
aiua-13318	71	12	97(1):13318	97(1):13318	NUM
aiua-13318	71	13	3	3	NUM
aiua-13318	71	14	srd5ar2	srd5ar2	PROPN
aiua-13318	71	15	gene	gene	NOUN
aiua-13318	71	16	association	association	NOUN
aiua-13318	71	17	with	with	ADP
aiua-13318	71	18	benign	benign	ADJ
aiua-13318	71	19	prostate	prostate	NOUN
aiua-13318	71	20	hyperplasia	hyperplasia	NOUN
aiua-13318	71	21	and	and	CCONJ
aiua-13318	71	22	prostate	prostate	NOUN
aiua-13318	71	23	cancer	cancer	NOUN
aiua-13318	71	24	figure	figure	NOUN
aiua-13318	71	25	1	1	NUM
aiua-13318	71	26	.	.	PUNCT
aiua-13318	71	27	prisma	prisma	PROPN
aiua-13318	71	28	flowchart	flowchart	PROPN
aiua-13318	71	29	of	of	ADP
aiua-13318	71	30	the	the	DET
aiua-13318	71	31	literature	literature	NOUN
aiua-13318	71	32	selection	selection	NOUN
aiua-13318	71	33	.	.	PUNCT
aiua-13318	72	1	figure	figure	NOUN
aiua-13318	72	2	2	2	NUM
aiua-13318	72	3	.	.	PUNCT
aiua-13318	73	1	risk	risk	NOUN
aiua-13318	73	2	of	of	ADP
aiua-13318	73	3	bias	bias	NOUN
aiua-13318	73	4	assessment	assessment	NOUN
aiua-13318	73	5	archivio	archivio	NOUN
aiua-13318	73	6	italiano	italiano	X
aiua-13318	73	7	di	di	X
aiua-13318	73	8	urologia	urologia	PROPN
aiua-13318	73	9	e	e	PROPN
aiua-13318	73	10	andrologia	andrologia	NOUN
aiua-13318	73	11	2025	2025	NUM
aiua-13318	73	12	;	;	PUNCT
aiua-13318	73	13	97(1):13318	97(1):13318	PROPN
aiua-13318	73	14	r.	r.	PROPN
aiua-13318	73	15	maharani	maharani	PROPN
aiua-13318	73	16	,	,	PUNCT
aiua-13318	73	17	h.	h.	PROPN
aiua-13318	73	18	lestari	lestari	PROPN
aiua-13318	73	19	,	,	PUNCT
aiua-13318	73	20	p.	p.	PROPN
aiua-13318	73	21	mahakarya	mahakarya	PROPN
aiua-13318	73	22	dewa	dewa	PROPN
aiua-13318	73	23	,	,	PUNCT
aiua-13318	73	24	et	et	PROPN
aiua-13318	73	25	al	al	PROPN
aiua-13318	73	26	.	.	PROPN
aiua-13318	73	27	4	4	NUM
aiua-13318	73	28	variants	variant	NOUN
aiua-13318	73	29	were	be	AUX
aiua-13318	73	30	more	more	ADV
aiua-13318	73	31	frequently	frequently	ADV
aiua-13318	73	32	found	find	VERB
aiua-13318	73	33	among	among	ADP
aiua-13318	73	34	prostate	prostate	NOUN
aiua-13318	73	35	cancer	cancer	NOUN
aiua-13318	73	36	patients	patient	NOUN
aiua-13318	73	37	while	while	SCONJ
aiua-13318	73	38	“	"	PUNCT
aiua-13318	73	39	aa	aa	PROPN
aiua-13318	73	40	”	"	PUNCT
aiua-13318	73	41	variants	variant	NOUN
aiua-13318	73	42	were	be	AUX
aiua-13318	73	43	least	least	ADV
aiua-13318	73	44	likely	likely	ADJ
aiua-13318	73	45	to	to	PART
aiua-13318	73	46	be	be	AUX
aiua-13318	73	47	found	find	VERB
aiua-13318	73	48	on	on	ADP
aiua-13318	73	49	patients	patient	NOUN
aiua-13318	73	50	with	with	ADP
aiua-13318	73	51	prostate	prostate	NOUN
aiua-13318	73	52	cancer	cancer	NOUN
aiua-13318	73	53	and	and	CCONJ
aiua-13318	73	54	bph	bph	NOUN
aiua-13318	73	55	.	.	PUNCT
aiua-13318	74	1	response	response	NOUN
aiua-13318	74	2	to	to	ADP
aiua-13318	74	3	drugs	drug	NOUN
aiua-13318	74	4	both	both	DET
aiua-13318	74	5	genes	gene	NOUN
aiua-13318	74	6	demonstrated	demonstrate	VERB
aiua-13318	74	7	a	a	DET
aiua-13318	74	8	protective	protective	ADJ
aiua-13318	74	9	effect	effect	NOUN
aiua-13318	74	10	against	against	ADP
aiua-13318	74	11	the	the	DET
aiua-13318	74	12	clinical	clinical	ADJ
aiua-13318	74	13	progression	progression	NOUN
aiua-13318	74	14	of	of	ADP
aiua-13318	74	15	bph	bph	NOUN
aiua-13318	74	16	when	when	SCONJ
aiua-13318	74	17	treated	treat	VERB
aiua-13318	74	18	with	with	ADP
aiua-13318	74	19	5α	5α	ADJ
aiua-13318	74	20	-	-	PUNCT
aiua-13318	74	21	reductase	reductase	NOUN
aiua-13318	74	22	inhibitors	inhibitor	NOUN
aiua-13318	74	23	,	,	PUNCT
aiua-13318	74	24	α	α	NOUN
aiua-13318	74	25	-	-	ADJ
aiua-13318	74	26	adrenergic	adrenergic	ADJ
aiua-13318	74	27	receptor	receptor	NOUN
aiua-13318	74	28	antagonists	antagonist	NOUN
aiua-13318	74	29	,	,	PUNCT
aiua-13318	74	30	and	and	CCONJ
aiua-13318	74	31	alpha	alpha	NOUN
aiua-13318	74	32	blockers	blocker	NOUN
aiua-13318	74	33	.	.	PUNCT
aiua-13318	75	1	populations	population	NOUN
aiua-13318	75	2	with	with	ADP
aiua-13318	75	3	the	the	DET
aiua-13318	75	4	“	"	PUNCT
aiua-13318	75	5	ll	ll	NOUN
aiua-13318	75	6	”	"	PUNCT
aiua-13318	75	7	genotype	genotype	NOUN
aiua-13318	75	8	were	be	AUX
aiua-13318	75	9	likely	likely	ADV
aiua-13318	75	10	more	more	ADV
aiua-13318	75	11	suitable	suitable	ADJ
aiua-13318	75	12	to	to	PART
aiua-13318	75	13	have	have	VERB
aiua-13318	75	14	a	a	DET
aiua-13318	75	15	standard	standard	ADJ
aiua-13318	75	16	or	or	CCONJ
aiua-13318	75	17	herbal	herbal	ADJ
aiua-13318	75	18	treatment	treatment	NOUN
aiua-13318	75	19	for	for	ADP
aiua-13318	75	20	bph	bph	NOUN
aiua-13318	75	21	.	.	PUNCT
aiua-13318	76	1	discussion	discussion	NOUN
aiua-13318	76	2	the	the	DET
aiua-13318	76	3	results	result	NOUN
aiua-13318	76	4	of	of	ADP
aiua-13318	76	5	the	the	DET
aiua-13318	76	6	present	present	ADJ
aiua-13318	76	7	study	study	NOUN
aiua-13318	76	8	,	,	PUNCT
aiua-13318	76	9	when	when	SCONJ
aiua-13318	76	10	contextualized	contextualize	VERB
aiua-13318	76	11	with	with	ADP
aiua-13318	76	12	previous	previous	ADJ
aiua-13318	76	13	research	research	NOUN
aiua-13318	76	14	(	(	PUNCT
aiua-13318	76	15	11	11	NUM
aiua-13318	76	16	-	-	SYM
aiua-13318	76	17	16	16	NUM
aiua-13318	76	18	)	)	PUNCT
aiua-13318	76	19	,	,	PUNCT
aiua-13318	76	20	provide	provide	VERB
aiua-13318	76	21	a	a	DET
aiua-13318	76	22	deeper	deep	ADJ
aiua-13318	76	23	understanding	understanding	NOUN
aiua-13318	76	24	of	of	ADP
aiua-13318	76	25	the	the	DET
aiua-13318	76	26	role	role	NOUN
aiua-13318	76	27	of	of	ADP
aiua-13318	76	28	genetic	genetic	ADJ
aiua-13318	76	29	polymorphisms	polymorphism	NOUN
aiua-13318	76	30	in	in	ADP
aiua-13318	76	31	the	the	DET
aiua-13318	76	32	srd5a2	srd5a2	NOUN
aiua-13318	76	33	gene	gene	NOUN
aiua-13318	76	34	,	,	PUNCT
aiua-13318	76	35	particularly	particularly	ADV
aiua-13318	76	36	v89l	v89l	NUM
aiua-13318	76	37	and	and	CCONJ
aiua-13318	76	38	a49	a49	PROPN
aiua-13318	76	39	t	t	PROPN
aiua-13318	76	40	,	,	PUNCT
aiua-13318	76	41	in	in	ADP
aiua-13318	76	42	the	the	DET
aiua-13318	76	43	development	development	NOUN
aiua-13318	76	44	and	and	CCONJ
aiua-13318	76	45	progression	progression	NOUN
aiua-13318	76	46	of	of	ADP
aiua-13318	76	47	prostate	prostate	ADJ
aiua-13318	76	48	pathological	pathological	ADJ
aiua-13318	76	49	conditions	condition	NOUN
aiua-13318	76	50	like	like	ADP
aiua-13318	76	51	bph	bph	NOUN
aiua-13318	76	52	and	and	CCONJ
aiua-13318	76	53	prostate	prostate	NOUN
aiua-13318	76	54	cancer	cancer	NOUN
aiua-13318	76	55	(	(	PUNCT
aiua-13318	76	56	pca	pca	PROPN
aiua-13318	76	57	)	)	PUNCT
aiua-13318	76	58	.	.	PUNCT
aiua-13318	77	1	the	the	DET
aiua-13318	77	2	associations	association	NOUN
aiua-13318	77	3	between	between	ADP
aiua-13318	77	4	these	these	DET
aiua-13318	77	5	polymorphisms	polymorphism	NOUN
aiua-13318	77	6	and	and	CCONJ
aiua-13318	77	7	disease	disease	NOUN
aiua-13318	77	8	risk	risk	NOUN
aiua-13318	77	9	highlight	highlight	VERB
aiua-13318	77	10	the	the	DET
aiua-13318	77	11	genetic	genetic	ADJ
aiua-13318	77	12	mechanisms	mechanism	NOUN
aiua-13318	77	13	that	that	PRON
aiua-13318	77	14	may	may	AUX
aiua-13318	77	15	influence	influence	VERB
aiua-13318	77	16	prostate	prostate	NOUN
aiua-13318	77	17	enlargement	enlargement	NOUN
aiua-13318	77	18	and	and	CCONJ
aiua-13318	77	19	malignancy	malignancy	NOUN
aiua-13318	77	20	,	,	PUNCT
aiua-13318	77	21	as	as	ADV
aiua-13318	77	22	well	well	ADV
aiua-13318	77	23	as	as	ADP
aiua-13318	77	24	the	the	DET
aiua-13318	77	25	potential	potential	NOUN
aiua-13318	77	26	for	for	ADP
aiua-13318	77	27	personalized	personalized	ADJ
aiua-13318	77	28	treatment	treatment	NOUN
aiua-13318	77	29	strategies	strategy	NOUN
aiua-13318	77	30	based	base	VERB
aiua-13318	77	31	on	on	ADP
aiua-13318	77	32	these	these	DET
aiua-13318	77	33	genetic	genetic	ADJ
aiua-13318	77	34	markers	marker	NOUN
aiua-13318	77	35	.	.	PUNCT
aiua-13318	78	1	our	our	PRON
aiua-13318	78	2	findings	finding	NOUN
aiua-13318	78	3	on	on	ADP
aiua-13318	78	4	the	the	DET
aiua-13318	78	5	v89l	v89l	PROPN
aiua-13318	78	6	polymorphism	polymorphism	NOUN
aiua-13318	78	7	align	align	VERB
aiua-13318	78	8	with	with	ADP
aiua-13318	78	9	previous	previous	ADJ
aiua-13318	78	10	studies	study	NOUN
aiua-13318	78	11	showing	show	VERB
aiua-13318	78	12	that	that	SCONJ
aiua-13318	78	13	the	the	DET
aiua-13318	78	14	srd5a2	srd5a2	NOUN
aiua-13318	78	15	gene	gene	NOUN
aiua-13318	78	16	encoding	encode	VERB
aiua-13318	78	17	an	an	DET
aiua-13318	78	18	enzyme	enzyme	NOUN
aiua-13318	78	19	responsible	responsible	ADJ
aiua-13318	78	20	for	for	ADP
aiua-13318	78	21	converting	convert	VERB
aiua-13318	78	22	testosterone	testosterone	NOUN
aiua-13318	78	23	into	into	ADP
aiua-13318	78	24	dihydrotestosterone	dihydrotestosterone	NOUN
aiua-13318	78	25	(	(	PUNCT
aiua-13318	78	26	dht	dht	NOUN
aiua-13318	78	27	)	)	PUNCT
aiua-13318	78	28	,	,	PUNCT
aiua-13318	78	29	plays	play	VERB
aiua-13318	78	30	a	a	DET
aiua-13318	78	31	key	key	ADJ
aiua-13318	78	32	role	role	NOUN
aiua-13318	78	33	in	in	ADP
aiua-13318	78	34	prostate	prostate	NOUN
aiua-13318	78	35	growth	growth	NOUN
aiua-13318	78	36	.	.	PUNCT
aiua-13318	79	1	the	the	DET
aiua-13318	79	2	activity	activity	NOUN
aiua-13318	79	3	of	of	ADP
aiua-13318	79	4	this	this	DET
aiua-13318	79	5	enzyme	enzyme	NOUN
aiua-13318	79	6	also	also	ADV
aiua-13318	79	7	known	know	VERB
aiua-13318	79	8	as	as	ADP
aiua-13318	79	9	5	5	NUM
aiua-13318	79	10	-	-	PUNCT
aiua-13318	79	11	alpha	alpha	NOUN
aiua-13318	79	12	reductase	reductase	NOUN
aiua-13318	79	13	type	type	NOUN
aiua-13318	79	14	2	2	NUM
aiua-13318	79	15	is	be	AUX
aiua-13318	79	16	linked	link	VERB
aiua-13318	79	17	to	to	ADP
aiua-13318	79	18	the	the	DET
aiua-13318	79	19	severity	severity	NOUN
aiua-13318	79	20	of	of	ADP
aiua-13318	79	21	bph	bph	NOUN
aiua-13318	79	22	.	.	PUNCT
aiua-13318	80	1	the	the	DET
aiua-13318	80	2	v89l	v89l	PROPN
aiua-13318	80	3	polymorphism	polymorphism	NOUN
aiua-13318	80	4	shows	show	VERB
aiua-13318	80	5	distinct	distinct	ADJ
aiua-13318	80	6	enzyme	enzyme	NOUN
aiua-13318	80	7	activity	activity	NOUN
aiua-13318	80	8	variations	variation	NOUN
aiua-13318	80	9	that	that	PRON
aiua-13318	80	10	influence	influence	NOUN
aiua-13318	80	11	androgen	androgen	NOUN
aiua-13318	80	12	levels	level	NOUN
aiua-13318	80	13	and	and	CCONJ
aiua-13318	80	14	drive	drive	VERB
aiua-13318	80	15	prostate	prostate	NOUN
aiua-13318	80	16	growth	growth	NOUN
aiua-13318	80	17	,	,	PUNCT
aiua-13318	80	18	potentially	potentially	ADV
aiua-13318	80	19	leading	lead	VERB
aiua-13318	80	20	to	to	ADP
aiua-13318	80	21	prostate	prostate	NOUN
aiua-13318	80	22	cancer	cancer	NOUN
aiua-13318	80	23	.	.	PUNCT
aiua-13318	81	1	our	our	PRON
aiua-13318	81	2	review	review	NOUN
aiua-13318	81	3	found	find	VERB
aiua-13318	81	4	that	that	SCONJ
aiua-13318	81	5	the	the	DET
aiua-13318	81	6	"	"	PUNCT
aiua-13318	81	7	ll	ll	NOUN
aiua-13318	81	8	"	"	PUNCT
aiua-13318	81	9	genotype	genotype	NOUN
aiua-13318	81	10	is	be	AUX
aiua-13318	81	11	less	less	ADV
aiua-13318	81	12	common	common	ADJ
aiua-13318	81	13	in	in	ADP
aiua-13318	81	14	prostate	prostate	NOUN
aiua-13318	81	15	cancer	cancer	NOUN
aiua-13318	81	16	patients	patient	NOUN
aiua-13318	81	17	,	,	PUNCT
aiua-13318	81	18	suggesting	suggest	VERB
aiua-13318	81	19	that	that	SCONJ
aiua-13318	81	20	this	this	DET
aiua-13318	81	21	allele	allele	NOUN
aiua-13318	81	22	may	may	AUX
aiua-13318	81	23	have	have	VERB
aiua-13318	81	24	a	a	DET
aiua-13318	81	25	protective	protective	ADJ
aiua-13318	81	26	effect	effect	NOUN
aiua-13318	81	27	by	by	ADP
aiua-13318	81	28	lowering	lower	VERB
aiua-13318	81	29	5	5	NUM
aiua-13318	81	30	-	-	PUNCT
aiua-13318	81	31	alpha	alpha	NOUN
aiua-13318	81	32	reductase	reductase	NOUN
aiua-13318	81	33	activity	activity	NOUN
aiua-13318	81	34	and	and	CCONJ
aiua-13318	81	35	,	,	PUNCT
aiua-13318	81	36	consequently	consequently	ADV
aiua-13318	81	37	,	,	PUNCT
aiua-13318	81	38	dht	dht	NOUN
aiua-13318	81	39	production	production	NOUN
aiua-13318	81	40	.	.	PUNCT
aiua-13318	82	1	table	table	NOUN
aiua-13318	82	2	1	1	NUM
aiua-13318	82	3	.	.	PUNCT
aiua-13318	82	4	gene	gene	NOUN
aiua-13318	82	5	polymorphism	polymorphism	NOUN
aiua-13318	82	6	.	.	PUNCT
aiua-13318	83	1	archivio	archivio	NOUN
aiua-13318	83	2	italiano	italiano	PROPN
aiua-13318	83	3	di	di	PROPN
aiua-13318	83	4	urologia	urologia	PROPN
aiua-13318	83	5	e	e	PROPN
aiua-13318	83	6	andrologia	andrologia	NOUN
aiua-13318	83	7	2025	2025	NUM
aiua-13318	83	8	;	;	PUNCT
aiua-13318	83	9	97(1):13318	97(1):13318	NUM
aiua-13318	83	10	5	5	NUM
aiua-13318	83	11	srd5ar2	srd5ar2	PROPN
aiua-13318	83	12	gene	gene	NOUN
aiua-13318	83	13	association	association	NOUN
aiua-13318	83	14	with	with	ADP
aiua-13318	83	15	benign	benign	ADJ
aiua-13318	83	16	prostate	prostate	NOUN
aiua-13318	83	17	hyperplasia	hyperplasia	NOUN
aiua-13318	83	18	and	and	CCONJ
aiua-13318	83	19	prostate	prostate	NOUN
aiua-13318	83	20	cancer	cancer	NOUN
aiua-13318	83	21	table	table	NOUN
aiua-13318	83	22	2	2	NUM
aiua-13318	83	23	.	.	PUNCT
aiua-13318	83	24	prognostic	prognostic	ADJ
aiua-13318	83	25	to	to	ADP
aiua-13318	83	26	malignancy	malignancy	NOUN
aiua-13318	83	27	archivio	archivio	NOUN
aiua-13318	83	28	italiano	italiano	X
aiua-13318	83	29	di	di	X
aiua-13318	83	30	urologia	urologia	PROPN
aiua-13318	83	31	e	e	PROPN
aiua-13318	83	32	andrologia	andrologia	NOUN
aiua-13318	83	33	2025	2025	NUM
aiua-13318	83	34	;	;	PUNCT
aiua-13318	83	35	97(1):13318	97(1):13318	PROPN
aiua-13318	83	36	r.	r.	PROPN
aiua-13318	83	37	maharani	maharani	PROPN
aiua-13318	83	38	,	,	PUNCT
aiua-13318	83	39	h.	h.	PROPN
aiua-13318	83	40	lestari	lestari	PROPN
aiua-13318	83	41	,	,	PUNCT
aiua-13318	83	42	p.	p.	PROPN
aiua-13318	83	43	mahakarya	mahakarya	PROPN
aiua-13318	83	44	dewa	dewa	PROPN
aiua-13318	83	45	,	,	PUNCT
aiua-13318	83	46	et	et	PROPN
aiua-13318	83	47	al	al	PROPN
aiua-13318	83	48	.	.	PROPN
aiua-13318	83	49	6	6	NUM
aiua-13318	83	50	these	these	DET
aiua-13318	83	51	results	result	NOUN
aiua-13318	83	52	are	be	AUX
aiua-13318	83	53	consistent	consistent	ADJ
aiua-13318	83	54	with	with	ADP
aiua-13318	83	55	a	a	DET
aiua-13318	83	56	study	study	NOUN
aiua-13318	83	57	by	by	ADP
aiua-13318	83	58	konwar	konwar	PROPN
aiua-13318	83	59	et	et	PROPN
aiua-13318	83	60	al	al	PROPN
aiua-13318	83	61	.	.	PROPN
aiua-13318	84	1	(	(	PUNCT
aiua-13318	84	2	17	17	NUM
aiua-13318	84	3	)	)	PUNCT
aiua-13318	84	4	,	,	PUNCT
aiua-13318	84	5	which	which	PRON
aiua-13318	84	6	reported	report	VERB
aiua-13318	84	7	that	that	SCONJ
aiua-13318	84	8	the	the	DET
aiua-13318	84	9	ll	ll	NOUN
aiua-13318	84	10	genotype	genotype	NOUN
aiua-13318	84	11	is	be	AUX
aiua-13318	84	12	associated	associate	VERB
aiua-13318	84	13	with	with	ADP
aiua-13318	84	14	lower	low	ADJ
aiua-13318	84	15	androstanediol	androstanediol	NOUN
aiua-13318	84	16	glucuronide	glucuronide	ADJ
aiua-13318	84	17	concentrations	concentration	NOUN
aiua-13318	84	18	,	,	PUNCT
aiua-13318	84	19	thereby	thereby	ADV
aiua-13318	84	20	reducing	reduce	VERB
aiua-13318	84	21	free	free	ADJ
aiua-13318	84	22	testosterone	testosterone	NOUN
aiua-13318	84	23	and	and	CCONJ
aiua-13318	84	24	dht	dht	NOUN
aiua-13318	84	25	levels	level	NOUN
aiua-13318	84	26	.	.	PUNCT
aiua-13318	85	1	this	this	PRON
aiua-13318	85	2	may	may	AUX
aiua-13318	85	3	explain	explain	VERB
aiua-13318	85	4	the	the	DET
aiua-13318	85	5	reduced	reduce	VERB
aiua-13318	85	6	prostate	prostate	NOUN
aiua-13318	85	7	volume	volume	NOUN
aiua-13318	85	8	and	and	CCONJ
aiua-13318	85	9	lower	low	ADJ
aiua-13318	85	10	cancer	cancer	NOUN
aiua-13318	85	11	risk	risk	NOUN
aiua-13318	85	12	in	in	ADP
aiua-13318	85	13	individuals	individual	NOUN
aiua-13318	85	14	with	with	ADP
aiua-13318	85	15	the	the	DET
aiua-13318	85	16	"	"	PUNCT
aiua-13318	85	17	ll	ll	NOUN
aiua-13318	85	18	"	"	PUNCT
aiua-13318	85	19	genotype	genotype	NOUN
aiua-13318	85	20	compared	compare	VERB
aiua-13318	85	21	to	to	ADP
aiua-13318	85	22	those	those	PRON
aiua-13318	85	23	with	with	ADP
aiua-13318	85	24	the	the	DET
aiua-13318	85	25	"	"	PUNCT
aiua-13318	85	26	vv	vv	NOUN
aiua-13318	85	27	"	"	PUNCT
aiua-13318	85	28	genotype	genotype	NOUN
aiua-13318	85	29	.	.	PUNCT
aiua-13318	86	1	furthermore	furthermore	ADV
aiua-13318	86	2	,	,	PUNCT
aiua-13318	86	3	the	the	DET
aiua-13318	86	4	higher	high	ADJ
aiua-13318	86	5	risk	risk	NOUN
aiua-13318	86	6	of	of	ADP
aiua-13318	86	7	bph	bph	NOUN
aiua-13318	86	8	associated	associate	VERB
aiua-13318	86	9	with	with	ADP
aiua-13318	86	10	the	the	DET
aiua-13318	86	11	"	"	PUNCT
aiua-13318	86	12	vv	vv	NOUN
aiua-13318	86	13	"	"	PUNCT
aiua-13318	86	14	allele	allele	NOUN
aiua-13318	86	15	was	be	AUX
aiua-13318	86	16	also	also	ADV
aiua-13318	86	17	supported	support	VERB
aiua-13318	86	18	by	by	ADP
aiua-13318	86	19	lunn	lunn	PROPN
aiua-13318	86	20	et	et	PROPN
aiua-13318	86	21	al	al	PROPN
aiua-13318	86	22	.	.	PROPN
aiua-13318	87	1	(	(	PUNCT
aiua-13318	87	2	18	18	NUM
aiua-13318	87	3	)	)	PUNCT
aiua-13318	87	4	research	research	NOUN
aiua-13318	87	5	,	,	PUNCT
aiua-13318	87	6	which	which	PRON
aiua-13318	87	7	indicated	indicate	VERB
aiua-13318	87	8	ethnic	ethnic	ADJ
aiua-13318	87	9	differences	difference	NOUN
aiua-13318	87	10	in	in	ADP
aiua-13318	87	11	v89l	v89l	PROPN
aiua-13318	87	12	polymorphism	polymorphism	NOUN
aiua-13318	87	13	prevalence	prevalence	NOUN
aiua-13318	87	14	.	.	PUNCT
aiua-13318	88	1	in	in	ADP
aiua-13318	88	2	asian	asian	ADJ
aiua-13318	88	3	populations	population	NOUN
aiua-13318	88	4	,	,	PUNCT
aiua-13318	88	5	such	such	ADJ
aiua-13318	88	6	as	as	ADP
aiua-13318	88	7	those	those	PRON
aiua-13318	88	8	in	in	ADP
aiua-13318	88	9	india	india	PROPN
aiua-13318	88	10	and	and	CCONJ
aiua-13318	88	11	japan	japan	PROPN
aiua-13318	88	12	,	,	PUNCT
aiua-13318	88	13	the	the	DET
aiua-13318	88	14	polymorphism	polymorphism	NOUN
aiua-13318	88	15	was	be	AUX
aiua-13318	88	16	found	find	VERB
aiua-13318	88	17	at	at	ADP
aiua-13318	88	18	higher	high	ADJ
aiua-13318	88	19	rates	rate	NOUN
aiua-13318	88	20	,	,	PUNCT
aiua-13318	88	21	contributtable	contributtable	ADJ
aiua-13318	88	22	3	3	NUM
aiua-13318	88	23	.	.	PUNCT
aiua-13318	88	24	response	response	NOUN
aiua-13318	88	25	to	to	ADP
aiua-13318	88	26	medical	medical	ADJ
aiua-13318	88	27	treatment	treatment	NOUN
aiua-13318	88	28	.	.	PUNCT
aiua-13318	89	1	archivio	archivio	NOUN
aiua-13318	89	2	italiano	italiano	PROPN
aiua-13318	89	3	di	di	PROPN
aiua-13318	89	4	urologia	urologia	PROPN
aiua-13318	89	5	e	e	PROPN
aiua-13318	89	6	andrologia	andrologia	NOUN
aiua-13318	89	7	2025	2025	NUM
aiua-13318	89	8	;	;	PUNCT
aiua-13318	89	9	97(1):13318	97(1):13318	NUM
aiua-13318	89	10	7	7	NUM
aiua-13318	89	11	srd5ar2	srd5ar2	PROPN
aiua-13318	89	12	gene	gene	NOUN
aiua-13318	89	13	association	association	NOUN
aiua-13318	89	14	with	with	ADP
aiua-13318	89	15	benign	benign	ADJ
aiua-13318	89	16	prostate	prostate	NOUN
aiua-13318	89	17	hyperplasia	hyperplasia	NOUN
aiua-13318	89	18	and	and	CCONJ
aiua-13318	89	19	prostate	prostate	NOUN
aiua-13318	89	20	cancer	cancer	NOUN
aiua-13318	89	21	ing	ing	ADJ
aiua-13318	89	22	to	to	ADP
aiua-13318	89	23	an	an	DET
aiua-13318	89	24	increased	increase	VERB
aiua-13318	89	25	risk	risk	NOUN
aiua-13318	89	26	of	of	ADP
aiua-13318	89	27	bph	bph	NOUN
aiua-13318	89	28	.	.	PUNCT
aiua-13318	90	1	this	this	PRON
aiua-13318	90	2	suggests	suggest	VERB
aiua-13318	90	3	that	that	SCONJ
aiua-13318	90	4	the	the	DET
aiua-13318	90	5	genetic	genetic	ADJ
aiua-13318	90	6	impact	impact	NOUN
aiua-13318	90	7	of	of	ADP
aiua-13318	90	8	the	the	DET
aiua-13318	90	9	v89l	v89l	ADJ
aiua-13318	90	10	variant	variant	NOUN
aiua-13318	90	11	may	may	AUX
aiua-13318	90	12	vary	vary	VERB
aiua-13318	90	13	across	across	ADP
aiua-13318	90	14	different	different	ADJ
aiua-13318	90	15	ethnicities	ethnicity	NOUN
aiua-13318	90	16	,	,	PUNCT
aiua-13318	90	17	with	with	ADP
aiua-13318	90	18	certain	certain	ADJ
aiua-13318	90	19	populations	population	NOUN
aiua-13318	90	20	exhibiting	exhibit	VERB
aiua-13318	90	21	a	a	DET
aiua-13318	90	22	higher	high	ADJ
aiua-13318	90	23	predisposition	predisposition	NOUN
aiua-13318	90	24	to	to	ADP
aiua-13318	90	25	prostate	prostate	NOUN
aiua-13318	90	26	diseases	disease	NOUN
aiua-13318	90	27	.	.	PUNCT
aiua-13318	91	1	regarding	regard	VERB
aiua-13318	91	2	the	the	DET
aiua-13318	91	3	a49	a49	PROPN
aiua-13318	91	4	t	t	PROPN
aiua-13318	91	5	polymorphism	polymorphism	NOUN
aiua-13318	91	6	,	,	PUNCT
aiua-13318	91	7	our	our	PRON
aiua-13318	91	8	review	review	NOUN
aiua-13318	91	9	found	find	VERB
aiua-13318	91	10	no	no	DET
aiua-13318	91	11	statistically	statistically	ADV
aiua-13318	91	12	significant	significant	ADJ
aiua-13318	91	13	association	association	NOUN
aiua-13318	91	14	with	with	ADP
aiua-13318	91	15	malignancy	malignancy	NOUN
aiua-13318	91	16	,	,	PUNCT
aiua-13318	91	17	though	though	SCONJ
aiua-13318	91	18	the	the	DET
aiua-13318	91	19	"	"	PUNCT
aiua-13318	91	20	at	at	ADP
aiua-13318	91	21	"	"	PUNCT
aiua-13318	91	22	and	and	CCONJ
aiua-13318	91	23	"	"	PUNCT
aiua-13318	91	24	tt	tt	PROPN
aiua-13318	91	25	"	"	PUNCT
aiua-13318	91	26	genotypes	genotype	NOUN
aiua-13318	91	27	tended	tend	VERB
aiua-13318	91	28	to	to	PART
aiua-13318	91	29	be	be	AUX
aiua-13318	91	30	associated	associate	VERB
aiua-13318	91	31	with	with	ADP
aiua-13318	91	32	a	a	DET
aiua-13318	91	33	higher	high	ADJ
aiua-13318	91	34	risk	risk	NOUN
aiua-13318	91	35	of	of	ADP
aiua-13318	91	36	developing	develop	VERB
aiua-13318	91	37	prostate	prostate	NOUN
aiua-13318	91	38	cancer	cancer	NOUN
aiua-13318	91	39	compared	compare	VERB
aiua-13318	91	40	to	to	ADP
aiua-13318	91	41	the	the	DET
aiua-13318	91	42	"	"	PUNCT
aiua-13318	91	43	aa	aa	NOUN
aiua-13318	91	44	"	"	PUNCT
aiua-13318	91	45	genotype	genotype	NOUN
aiua-13318	91	46	.	.	PUNCT
aiua-13318	92	1	this	this	PRON
aiua-13318	92	2	aligns	align	VERB
aiua-13318	92	3	with	with	ADP
aiua-13318	92	4	giwerchman	giwerchman	NOUN
aiua-13318	92	5	et	et	PROPN
aiua-13318	92	6	al	al	PROPN
aiua-13318	92	7	.	.	PUNCT
aiua-13318	93	1	(	(	PUNCT
aiua-13318	93	2	15	15	NUM
aiua-13318	93	3	)	)	PUNCT
aiua-13318	93	4	,	,	PUNCT
aiua-13318	93	5	who	who	PRON
aiua-13318	93	6	estimated	estimate	VERB
aiua-13318	93	7	that	that	SCONJ
aiua-13318	93	8	the	the	DET
aiua-13318	93	9	a49	a49	PROPN
aiua-13318	93	10	t	t	PROPN
aiua-13318	93	11	polymorphism	polymorphism	NOUN
aiua-13318	93	12	could	could	AUX
aiua-13318	93	13	be	be	AUX
aiua-13318	93	14	found	find	VERB
aiua-13318	93	15	in	in	ADP
aiua-13318	93	16	approximately	approximately	ADV
aiua-13318	93	17	8	8	NUM
aiua-13318	93	18	%	%	NOUN
aiua-13318	93	19	of	of	ADP
aiua-13318	93	20	prostate	prostate	NOUN
aiua-13318	93	21	cancer	cancer	NOUN
aiua-13318	93	22	patients	patient	NOUN
aiua-13318	93	23	and	and	CCONJ
aiua-13318	93	24	6.3	6.3	NUM
aiua-13318	93	25	%	%	NOUN
aiua-13318	93	26	of	of	ADP
aiua-13318	93	27	bph	bph	NOUN
aiua-13318	93	28	patients	patient	NOUN
aiua-13318	93	29	,	,	PUNCT
aiua-13318	93	30	indicating	indicate	VERB
aiua-13318	93	31	its	its	PRON
aiua-13318	93	32	role	role	NOUN
aiua-13318	93	33	in	in	ADP
aiua-13318	93	34	increasing	increase	VERB
aiua-13318	93	35	the	the	DET
aiua-13318	93	36	probability	probability	NOUN
aiua-13318	93	37	of	of	ADP
aiua-13318	93	38	developing	develop	VERB
aiua-13318	93	39	bph	bph	NOUN
aiua-13318	93	40	and	and	CCONJ
aiua-13318	93	41	prostate	prostate	NOUN
aiua-13318	93	42	cancer	cancer	NOUN
aiua-13318	93	43	.	.	PUNCT
aiua-13318	94	1	although	although	SCONJ
aiua-13318	94	2	not	not	PART
aiua-13318	94	3	as	as	ADV
aiua-13318	94	4	prominent	prominent	ADJ
aiua-13318	94	5	in	in	ADP
aiua-13318	94	6	asian	asian	ADJ
aiua-13318	94	7	populations	population	NOUN
aiua-13318	94	8	,	,	PUNCT
aiua-13318	94	9	this	this	DET
aiua-13318	94	10	polymorphism	polymorphism	NOUN
aiua-13318	94	11	is	be	AUX
aiua-13318	94	12	commonly	commonly	ADV
aiua-13318	94	13	observed	observe	VERB
aiua-13318	94	14	in	in	ADP
aiua-13318	94	15	hispanic	hispanic	ADJ
aiua-13318	94	16	populations	population	NOUN
aiua-13318	94	17	,	,	PUNCT
aiua-13318	94	18	as	as	ADV
aiua-13318	94	19	well	well	ADV
aiua-13318	94	20	as	as	ADP
aiua-13318	94	21	in	in	ADP
aiua-13318	94	22	certain	certain	ADJ
aiua-13318	94	23	countries	country	NOUN
aiua-13318	94	24	like	like	ADP
aiua-13318	94	25	turkey	turkey	NOUN
aiua-13318	94	26	and	and	CCONJ
aiua-13318	94	27	china	china	PROPN
aiua-13318	94	28	.	.	PUNCT
aiua-13318	95	1	while	while	SCONJ
aiua-13318	95	2	the	the	DET
aiua-13318	95	3	statistical	statistical	ADJ
aiua-13318	95	4	significance	significance	NOUN
aiua-13318	95	5	of	of	ADP
aiua-13318	95	6	the	the	DET
aiua-13318	95	7	a49	a49	PROPN
aiua-13318	95	8	t	t	PROPN
aiua-13318	95	9	polymorphism	polymorphism	NOUN
aiua-13318	95	10	in	in	ADP
aiua-13318	95	11	relation	relation	NOUN
aiua-13318	95	12	to	to	ADP
aiua-13318	95	13	malignancy	malignancy	NOUN
aiua-13318	95	14	remains	remain	VERB
aiua-13318	95	15	inconclusive	inconclusive	ADJ
aiua-13318	95	16	in	in	ADP
aiua-13318	95	17	our	our	PRON
aiua-13318	95	18	review	review	NOUN
aiua-13318	95	19	,	,	PUNCT
aiua-13318	95	20	these	these	DET
aiua-13318	95	21	findings	finding	NOUN
aiua-13318	95	22	emphasize	emphasize	VERB
aiua-13318	95	23	its	its	PRON
aiua-13318	95	24	potential	potential	ADJ
aiua-13318	95	25	importance	importance	NOUN
aiua-13318	95	26	as	as	ADP
aiua-13318	95	27	a	a	DET
aiua-13318	95	28	genetic	genetic	ADJ
aiua-13318	95	29	marker	marker	NOUN
aiua-13318	95	30	for	for	ADP
aiua-13318	95	31	prostate	prostate	NOUN
aiua-13318	95	32	cancer	cancer	NOUN
aiua-13318	95	33	susceptibility	susceptibility	NOUN
aiua-13318	95	34	.	.	PUNCT
aiua-13318	96	1	this	this	DET
aiua-13318	96	2	warrants	warrant	NOUN
aiua-13318	96	3	further	further	ADJ
aiua-13318	96	4	research	research	NOUN
aiua-13318	96	5	,	,	PUNCT
aiua-13318	96	6	especially	especially	ADV
aiua-13318	96	7	in	in	ADP
aiua-13318	96	8	nonhispanic	nonhispanic	ADJ
aiua-13318	96	9	populations	population	NOUN
aiua-13318	96	10	,	,	PUNCT
aiua-13318	96	11	to	to	PART
aiua-13318	96	12	determine	determine	VERB
aiua-13318	96	13	whether	whether	SCONJ
aiua-13318	96	14	the	the	DET
aiua-13318	96	15	a49	a49	PROPN
aiua-13318	96	16	t	t	PROPN
aiua-13318	96	17	variant	variant	NOUN
aiua-13318	96	18	can	can	AUX
aiua-13318	96	19	be	be	AUX
aiua-13318	96	20	used	use	VERB
aiua-13318	96	21	as	as	ADP
aiua-13318	96	22	a	a	DET
aiua-13318	96	23	predictive	predictive	ADJ
aiua-13318	96	24	tool	tool	NOUN
aiua-13318	96	25	for	for	ADP
aiua-13318	96	26	prostate	prostate	NOUN
aiua-13318	96	27	disease	disease	NOUN
aiua-13318	96	28	risk	risk	NOUN
aiua-13318	96	29	in	in	ADP
aiua-13318	96	30	other	other	ADJ
aiua-13318	96	31	ethnic	ethnic	ADJ
aiua-13318	96	32	groups	group	NOUN
aiua-13318	96	33	.	.	PUNCT
aiua-13318	97	1	the	the	DET
aiua-13318	97	2	study	study	NOUN
aiua-13318	97	3	findings	finding	VERB
aiua-13318	97	4	on	on	ADP
aiua-13318	97	5	gene	gene	NOUN
aiua-13318	97	6	polymorphisms	polymorphism	NOUN
aiua-13318	97	7	in	in	ADP
aiua-13318	97	8	the	the	DET
aiua-13318	97	9	srd5a2	srd5a2	NOUN
aiua-13318	97	10	gene	gene	NOUN
aiua-13318	97	11	also	also	ADV
aiua-13318	97	12	underscore	underscore	VERB
aiua-13318	97	13	the	the	DET
aiua-13318	97	14	potential	potential	NOUN
aiua-13318	97	15	for	for	ADP
aiua-13318	97	16	personalized	personalized	ADJ
aiua-13318	97	17	medicine	medicine	NOUN
aiua-13318	97	18	in	in	ADP
aiua-13318	97	19	treating	treat	VERB
aiua-13318	97	20	prostate	prostate	NOUN
aiua-13318	97	21	-	-	PUNCT
aiua-13318	97	22	related	relate	VERB
aiua-13318	97	23	conditions	condition	NOUN
aiua-13318	97	24	.	.	PUNCT
aiua-13318	98	1	according	accord	VERB
aiua-13318	98	2	to	to	ADP
aiua-13318	98	3	li	li	PROPN
aiua-13318	98	4	et	et	PROPN
aiua-13318	98	5	al	al	PROPN
aiua-13318	98	6	.	.	PUNCT
aiua-13318	99	1	(	(	PUNCT
aiua-13318	99	2	14	14	NUM
aiua-13318	99	3	)	)	PUNCT
aiua-13318	99	4	,	,	PUNCT
aiua-13318	99	5	the	the	DET
aiua-13318	99	6	srd5a2	srd5a2	NOUN
aiua-13318	99	7	gene	gene	NOUN
aiua-13318	99	8	regulates	regulate	VERB
aiua-13318	99	9	critical	critical	ADJ
aiua-13318	99	10	hormonal	hormonal	ADJ
aiua-13318	99	11	pathways	pathway	NOUN
aiua-13318	99	12	,	,	PUNCT
aiua-13318	99	13	influencing	influence	VERB
aiua-13318	99	14	prostate	prostate	NOUN
aiua-13318	99	15	growth	growth	NOUN
aiua-13318	99	16	and	and	CCONJ
aiua-13318	99	17	function	function	NOUN
aiua-13318	99	18	.	.	PUNCT
aiua-13318	100	1	this	this	DET
aiua-13318	100	2	insight	insight	NOUN
aiua-13318	100	3	into	into	ADP
aiua-13318	100	4	the	the	DET
aiua-13318	100	5	biochemical	biochemical	ADJ
aiua-13318	100	6	pathways	pathway	NOUN
aiua-13318	100	7	driven	drive	VERB
aiua-13318	100	8	by	by	ADP
aiua-13318	100	9	v89l	v89l	PROPN
aiua-13318	100	10	and	and	CCONJ
aiua-13318	100	11	a49	a49	PROPN
aiua-13318	100	12	t	t	PROPN
aiua-13318	100	13	polymorphisms	polymorphism	NOUN
aiua-13318	100	14	supports	support	VERB
aiua-13318	100	15	the	the	DET
aiua-13318	100	16	idea	idea	NOUN
aiua-13318	100	17	of	of	ADP
aiua-13318	100	18	genotype	genotype	NOUN
aiua-13318	100	19	-	-	PUNCT
aiua-13318	100	20	driven	drive	VERB
aiua-13318	100	21	therapeutic	therapeutic	ADJ
aiua-13318	100	22	approaches	approach	NOUN
aiua-13318	100	23	.	.	PUNCT
aiua-13318	101	1	both	both	PRON
aiua-13318	101	2	v89l	v89l	PROPN
aiua-13318	101	3	and	and	CCONJ
aiua-13318	101	4	a49	a49	PROPN
aiua-13318	101	5	t	t	PROPN
aiua-13318	101	6	polymorphisms	polymorphism	NOUN
aiua-13318	101	7	demonstrated	demonstrate	VERB
aiua-13318	101	8	protective	protective	ADJ
aiua-13318	101	9	effects	effect	NOUN
aiua-13318	101	10	against	against	ADP
aiua-13318	101	11	the	the	DET
aiua-13318	101	12	clinical	clinical	ADJ
aiua-13318	101	13	progression	progression	NOUN
aiua-13318	101	14	of	of	ADP
aiua-13318	101	15	bph	bph	NOUN
aiua-13318	101	16	when	when	SCONJ
aiua-13318	101	17	treated	treat	VERB
aiua-13318	101	18	with	with	ADP
aiua-13318	101	19	5	5	NUM
aiua-13318	101	20	-	-	PUNCT
aiua-13318	101	21	alpha	alpha	ADJ
aiua-13318	101	22	reductase	reductase	NOUN
aiua-13318	101	23	inhibitors	inhibitor	NOUN
aiua-13318	101	24	and	and	CCONJ
aiua-13318	101	25	αadrenergic	αadrenergic	ADJ
aiua-13318	101	26	receptor	receptor	NOUN
aiua-13318	101	27	antagonists	antagonist	NOUN
aiua-13318	101	28	.	.	PUNCT
aiua-13318	102	1	these	these	DET
aiua-13318	102	2	findings	finding	NOUN
aiua-13318	102	3	imply	imply	VERB
aiua-13318	102	4	that	that	SCONJ
aiua-13318	102	5	personalized	personalized	ADJ
aiua-13318	102	6	treatment	treatment	NOUN
aiua-13318	102	7	strategies	strategy	NOUN
aiua-13318	102	8	based	base	VERB
aiua-13318	102	9	on	on	ADP
aiua-13318	102	10	genetic	genetic	ADJ
aiua-13318	102	11	markers	marker	NOUN
aiua-13318	102	12	could	could	AUX
aiua-13318	102	13	optimize	optimize	VERB
aiua-13318	102	14	therapeutic	therapeutic	ADJ
aiua-13318	102	15	outcomes	outcome	NOUN
aiua-13318	102	16	and	and	CCONJ
aiua-13318	102	17	reduce	reduce	VERB
aiua-13318	102	18	the	the	DET
aiua-13318	102	19	likelihood	likelihood	NOUN
aiua-13318	102	20	of	of	ADP
aiua-13318	102	21	disease	disease	NOUN
aiua-13318	102	22	progression	progression	NOUN
aiua-13318	102	23	,	,	PUNCT
aiua-13318	102	24	offering	offer	VERB
aiua-13318	102	25	a	a	DET
aiua-13318	102	26	more	more	ADV
aiua-13318	102	27	tailored	tailor	VERB
aiua-13318	102	28	approach	approach	NOUN
aiua-13318	102	29	to	to	ADP
aiua-13318	102	30	managing	managing	NOUN
aiua-13318	102	31	bph	bph	NOUN
aiua-13318	102	32	and	and	CCONJ
aiua-13318	102	33	prostate	prostate	NOUN
aiua-13318	102	34	cancer	cancer	NOUN
aiua-13318	102	35	.	.	PUNCT
aiua-13318	103	1	a	a	DET
aiua-13318	103	2	study	study	NOUN
aiua-13318	103	3	by	by	ADP
aiua-13318	103	4	daryanto	daryanto	PROPN
aiua-13318	103	5	et	et	PROPN
aiua-13318	103	6	al	al	PROPN
aiua-13318	103	7	.	.	PROPN
aiua-13318	104	1	(	(	PUNCT
aiua-13318	104	2	19	19	NUM
aiua-13318	104	3	)	)	PUNCT
aiua-13318	104	4	showed	show	VERB
aiua-13318	104	5	that	that	DET
aiua-13318	104	6	combination	combination	NOUN
aiua-13318	104	7	of	of	ADP
aiua-13318	104	8	dutasteride	dutasteride	NOUN
aiua-13318	104	9	with	with	ADP
aiua-13318	104	10	tamsulosin	tamsulosin	NOUN
aiua-13318	104	11	could	could	AUX
aiua-13318	104	12	give	give	VERB
aiua-13318	104	13	a	a	DET
aiua-13318	104	14	more	more	ADV
aiua-13318	104	15	significant	significant	ADJ
aiua-13318	104	16	effect	effect	NOUN
aiua-13318	104	17	in	in	ADP
aiua-13318	104	18	terms	term	NOUN
aiua-13318	104	19	of	of	ADP
aiua-13318	104	20	lowering	lower	VERB
aiua-13318	104	21	the	the	DET
aiua-13318	104	22	contractility	contractility	NOUN
aiua-13318	104	23	of	of	ADP
aiua-13318	104	24	prostate	prostate	NOUN
aiua-13318	104	25	smooth	smooth	ADJ
aiua-13318	104	26	muscle	muscle	NOUN
aiua-13318	104	27	.	.	PUNCT
aiua-13318	105	1	while	while	SCONJ
aiua-13318	105	2	the	the	DET
aiua-13318	105	3	findings	finding	NOUN
aiua-13318	105	4	of	of	ADP
aiua-13318	105	5	this	this	DET
aiua-13318	105	6	review	review	NOUN
aiua-13318	105	7	are	be	AUX
aiua-13318	105	8	compelling	compelling	ADJ
aiua-13318	105	9	,	,	PUNCT
aiua-13318	105	10	they	they	PRON
aiua-13318	105	11	also	also	ADV
aiua-13318	105	12	reveal	reveal	VERB
aiua-13318	105	13	the	the	DET
aiua-13318	105	14	need	need	NOUN
aiua-13318	105	15	for	for	ADP
aiua-13318	105	16	further	further	ADJ
aiua-13318	105	17	research	research	NOUN
aiua-13318	105	18	.	.	PUNCT
aiua-13318	106	1	the	the	DET
aiua-13318	106	2	prevalence	prevalence	NOUN
aiua-13318	106	3	of	of	ADP
aiua-13318	106	4	v89l	v89l	PROPN
aiua-13318	106	5	and	and	CCONJ
aiua-13318	106	6	a49	a49	PROPN
aiua-13318	106	7	t	t	PROPN
aiua-13318	106	8	polymorphisms	polymorphism	NOUN
aiua-13318	106	9	in	in	ADP
aiua-13318	106	10	hispanic	hispanic	ADJ
aiua-13318	106	11	populations	population	NOUN
aiua-13318	106	12	has	have	AUX
aiua-13318	106	13	been	be	AUX
aiua-13318	106	14	well	well	ADV
aiua-13318	106	15	-	-	PUNCT
aiua-13318	106	16	documented	document	VERB
aiua-13318	106	17	,	,	PUNCT
aiua-13318	106	18	but	but	CCONJ
aiua-13318	106	19	additional	additional	ADJ
aiua-13318	106	20	studies	study	NOUN
aiua-13318	106	21	in	in	ADP
aiua-13318	106	22	asian	asian	ADJ
aiua-13318	106	23	populations	population	NOUN
aiua-13318	106	24	are	be	AUX
aiua-13318	106	25	necessary	necessary	ADJ
aiua-13318	106	26	to	to	PART
aiua-13318	106	27	understand	understand	VERB
aiua-13318	106	28	their	their	PRON
aiua-13318	106	29	role	role	NOUN
aiua-13318	106	30	in	in	ADP
aiua-13318	106	31	diverse	diverse	ADJ
aiua-13318	106	32	genetic	genetic	ADJ
aiua-13318	106	33	backgrounds	background	NOUN
aiua-13318	106	34	.	.	PUNCT
aiua-13318	107	1	for	for	ADP
aiua-13318	107	2	example	example	NOUN
aiua-13318	107	3	,	,	PUNCT
aiua-13318	107	4	as	as	SCONJ
aiua-13318	107	5	noted	note	VERB
aiua-13318	107	6	by	by	ADP
aiua-13318	107	7	lunn	lunn	PROPN
aiua-13318	107	8	et	et	PROPN
aiua-13318	107	9	al	al	PROPN
aiua-13318	107	10	.	.	PROPN
aiua-13318	108	1	(	(	PUNCT
aiua-13318	108	2	18	18	NUM
aiua-13318	108	3	)	)	PUNCT
aiua-13318	108	4	,	,	PUNCT
aiua-13318	108	5	the	the	DET
aiua-13318	108	6	v89l	v89l	PROPN
aiua-13318	108	7	polymorphism	polymorphism	NOUN
aiua-13318	108	8	shows	show	VERB
aiua-13318	108	9	high	high	ADJ
aiua-13318	108	10	prevalence	prevalence	NOUN
aiua-13318	108	11	in	in	ADP
aiua-13318	108	12	india	india	PROPN
aiua-13318	108	13	and	and	CCONJ
aiua-13318	108	14	japan	japan	PROPN
aiua-13318	108	15	,	,	PUNCT
aiua-13318	108	16	suggesting	suggest	VERB
aiua-13318	108	17	a	a	DET
aiua-13318	108	18	population	population	NOUN
aiua-13318	108	19	-	-	PUNCT
aiua-13318	108	20	specific	specific	ADJ
aiua-13318	108	21	effect	effect	NOUN
aiua-13318	108	22	.	.	PUNCT
aiua-13318	109	1	expanding	expand	VERB
aiua-13318	109	2	genetic	genetic	ADJ
aiua-13318	109	3	studies	study	NOUN
aiua-13318	109	4	to	to	PART
aiua-13318	109	5	include	include	VERB
aiua-13318	109	6	other	other	ADJ
aiua-13318	109	7	asian	asian	ADJ
aiua-13318	109	8	regions	region	NOUN
aiua-13318	109	9	may	may	AUX
aiua-13318	109	10	yield	yield	VERB
aiua-13318	109	11	valuable	valuable	ADJ
aiua-13318	109	12	insights	insight	NOUN
aiua-13318	109	13	into	into	ADP
aiua-13318	109	14	the	the	DET
aiua-13318	109	15	global	global	ADJ
aiua-13318	109	16	relevance	relevance	NOUN
aiua-13318	109	17	of	of	ADP
aiua-13318	109	18	these	these	DET
aiua-13318	109	19	polymorphisms	polymorphism	NOUN
aiua-13318	109	20	.	.	PUNCT
aiua-13318	110	1	additionally	additionally	ADV
aiua-13318	110	2	,	,	PUNCT
aiua-13318	110	3	larger	large	ADJ
aiua-13318	110	4	cohort	cohort	NOUN
aiua-13318	110	5	studies	study	NOUN
aiua-13318	110	6	and	and	CCONJ
aiua-13318	110	7	more	more	ADV
aiua-13318	110	8	diverse	diverse	ADJ
aiua-13318	110	9	population	population	NOUN
aiua-13318	110	10	sampling	sampling	NOUN
aiua-13318	110	11	are	be	AUX
aiua-13318	110	12	needed	need	VERB
aiua-13318	110	13	to	to	PART
aiua-13318	110	14	strengthen	strengthen	VERB
aiua-13318	110	15	the	the	DET
aiua-13318	110	16	associations	association	NOUN
aiua-13318	110	17	between	between	ADP
aiua-13318	110	18	these	these	DET
aiua-13318	110	19	polymorphisms	polymorphism	NOUN
aiua-13318	110	20	and	and	CCONJ
aiua-13318	110	21	prostate	prostate	NOUN
aiua-13318	110	22	cancer	cancer	NOUN
aiua-13318	110	23	or	or	CCONJ
aiua-13318	110	24	bph	bph	NOUN
aiua-13318	110	25	risk	risk	NOUN
aiua-13318	110	26	.	.	PUNCT
aiua-13318	111	1	a	a	DET
aiua-13318	111	2	more	more	ADV
aiua-13318	111	3	detailed	detailed	ADJ
aiua-13318	111	4	exploration	exploration	NOUN
aiua-13318	111	5	of	of	ADP
aiua-13318	111	6	the	the	DET
aiua-13318	111	7	mechanistic	mechanistic	ADJ
aiua-13318	111	8	pathways	pathway	NOUN
aiua-13318	111	9	involved	involve	VERB
aiua-13318	111	10	in	in	ADP
aiua-13318	111	11	dht	dht	NOUN
aiua-13318	111	12	production	production	NOUN
aiua-13318	111	13	and	and	CCONJ
aiua-13318	111	14	androgen	androgen	NOUN
aiua-13318	111	15	activity	activity	NOUN
aiua-13318	111	16	,	,	PUNCT
aiua-13318	111	17	particularly	particularly	ADV
aiua-13318	111	18	in	in	ADP
aiua-13318	111	19	relation	relation	NOUN
aiua-13318	111	20	to	to	ADP
aiua-13318	111	21	the	the	DET
aiua-13318	111	22	srd5a2	srd5a2	NOUN
aiua-13318	111	23	gene	gene	NOUN
aiua-13318	111	24	,	,	PUNCT
aiua-13318	111	25	will	will	AUX
aiua-13318	111	26	be	be	AUX
aiua-13318	111	27	essential	essential	ADJ
aiua-13318	111	28	for	for	ADP
aiua-13318	111	29	translating	translate	VERB
aiua-13318	111	30	these	these	DET
aiua-13318	111	31	genetic	genetic	ADJ
aiua-13318	111	32	insights	insight	NOUN
aiua-13318	111	33	into	into	ADP
aiua-13318	111	34	clinical	clinical	ADJ
aiua-13318	111	35	practice	practice	NOUN
aiua-13318	111	36	.	.	PUNCT
aiua-13318	112	1	this	this	DET
aiua-13318	112	2	study	study	NOUN
aiua-13318	112	3	confirms	confirm	VERB
aiua-13318	112	4	the	the	DET
aiua-13318	112	5	significant	significant	ADJ
aiua-13318	112	6	role	role	NOUN
aiua-13318	112	7	of	of	ADP
aiua-13318	112	8	the	the	DET
aiua-13318	112	9	srd5a2	srd5a2	NOUN
aiua-13318	112	10	gene	gene	NOUN
aiua-13318	112	11	and	and	CCONJ
aiua-13318	112	12	its	its	PRON
aiua-13318	112	13	v89l	v89l	PROPN
aiua-13318	112	14	and	and	CCONJ
aiua-13318	112	15	a49	a49	PROPN
aiua-13318	112	16	t	t	PROPN
aiua-13318	112	17	polymorphisms	polymorphism	NOUN
aiua-13318	112	18	,	,	PUNCT
aiua-13318	112	19	in	in	ADP
aiua-13318	112	20	influencing	influence	VERB
aiua-13318	112	21	the	the	DET
aiua-13318	112	22	risk	risk	NOUN
aiua-13318	112	23	of	of	ADP
aiua-13318	112	24	prostate	prostate	NOUN
aiua-13318	112	25	disease	disease	NOUN
aiua-13318	112	26	and	and	CCONJ
aiua-13318	112	27	its	its	PRON
aiua-13318	112	28	progression	progression	NOUN
aiua-13318	112	29	.	.	PUNCT
aiua-13318	113	1	both	both	DET
aiua-13318	113	2	variants	variant	NOUN
aiua-13318	113	3	have	have	VERB
aiua-13318	113	4	distinct	distinct	ADJ
aiua-13318	113	5	effects	effect	NOUN
aiua-13318	113	6	on	on	ADP
aiua-13318	113	7	the	the	DET
aiua-13318	113	8	enzyme	enzyme	NOUN
aiua-13318	113	9	activity	activity	NOUN
aiua-13318	113	10	and	and	CCONJ
aiua-13318	113	11	androgen	androgen	NOUN
aiua-13318	113	12	levels	level	NOUN
aiua-13318	113	13	,	,	PUNCT
aiua-13318	113	14	impacting	impact	VERB
aiua-13318	113	15	on	on	ADP
aiua-13318	113	16	prostate	prostate	NOUN
aiua-13318	113	17	growth	growth	NOUN
aiua-13318	113	18	and	and	CCONJ
aiua-13318	113	19	the	the	DET
aiua-13318	113	20	likelihood	likelihood	NOUN
aiua-13318	113	21	of	of	ADP
aiua-13318	113	22	developing	develop	VERB
aiua-13318	113	23	bph	bph	NOUN
aiua-13318	113	24	or	or	CCONJ
aiua-13318	113	25	prostate	prostate	NOUN
aiua-13318	113	26	cancer	cancer	NOUN
aiua-13318	113	27	.	.	PUNCT
aiua-13318	114	1	ethnic	ethnic	ADJ
aiua-13318	114	2	differences	difference	NOUN
aiua-13318	114	3	in	in	ADP
aiua-13318	114	4	polymorphism	polymorphism	NOUN
aiua-13318	114	5	prevalence	prevalence	NOUN
aiua-13318	114	6	further	far	ADV
aiua-13318	114	7	highlight	highlight	VERB
aiua-13318	114	8	the	the	DET
aiua-13318	114	9	importance	importance	NOUN
aiua-13318	114	10	of	of	ADP
aiua-13318	114	11	population	population	NOUN
aiua-13318	114	12	-	-	PUNCT
aiua-13318	114	13	specific	specific	ADJ
aiua-13318	114	14	genetic	genetic	ADJ
aiua-13318	114	15	research	research	NOUN
aiua-13318	114	16	.	.	PUNCT
aiua-13318	115	1	by	by	ADP
aiua-13318	115	2	integrating	integrate	VERB
aiua-13318	115	3	genetic	genetic	ADJ
aiua-13318	115	4	profiling	profiling	NOUN
aiua-13318	115	5	into	into	ADP
aiua-13318	115	6	clinical	clinical	ADJ
aiua-13318	115	7	practice	practice	NOUN
aiua-13318	115	8	,	,	PUNCT
aiua-13318	115	9	personalized	personalized	ADJ
aiua-13318	115	10	medicine	medicine	NOUN
aiua-13318	115	11	approaches	approach	NOUN
aiua-13318	115	12	may	may	AUX
aiua-13318	115	13	offer	offer	VERB
aiua-13318	115	14	more	more	ADV
aiua-13318	115	15	effective	effective	ADJ
aiua-13318	115	16	and	and	CCONJ
aiua-13318	115	17	targeted	target	VERB
aiua-13318	115	18	treatment	treatment	NOUN
aiua-13318	115	19	options	option	NOUN
aiua-13318	115	20	for	for	ADP
aiua-13318	115	21	prostate	prostate	NOUN
aiua-13318	115	22	-	-	PUNCT
aiua-13318	115	23	related	relate	VERB
aiua-13318	115	24	conditions	condition	NOUN
aiua-13318	115	25	,	,	PUNCT
aiua-13318	115	26	improving	improve	VERB
aiua-13318	115	27	patient	patient	ADJ
aiua-13318	115	28	outcomes	outcome	NOUN
aiua-13318	115	29	while	while	SCONJ
aiua-13318	115	30	minimizing	minimize	VERB
aiua-13318	115	31	unnecessary	unnecessary	ADJ
aiua-13318	115	32	interventions	intervention	NOUN
aiua-13318	115	33	.	.	PUNCT
aiua-13318	116	1	conclusions	conclusion	NOUN
aiua-13318	116	2	in	in	ADP
aiua-13318	116	3	conclusion	conclusion	NOUN
aiua-13318	116	4	,	,	PUNCT
aiua-13318	116	5	this	this	DET
aiua-13318	116	6	systematic	systematic	ADJ
aiua-13318	116	7	review	review	NOUN
aiua-13318	116	8	proves	prove	VERB
aiua-13318	116	9	that	that	SCONJ
aiua-13318	116	10	srd5a2	srd5a2	NOUN
aiua-13318	116	11	is	be	AUX
aiua-13318	116	12	a	a	DET
aiua-13318	116	13	high	high	ADJ
aiua-13318	116	14	susceptibility	susceptibility	NOUN
aiua-13318	116	15	gene	gene	NOUN
aiua-13318	116	16	that	that	PRON
aiua-13318	116	17	is	be	AUX
aiua-13318	116	18	linked	link	VERB
aiua-13318	116	19	to	to	ADP
aiua-13318	116	20	bph	bph	NOUN
aiua-13318	116	21	.	.	PUNCT
aiua-13318	117	1	a49	a49	PROPN
aiua-13318	117	2	t	t	PROPN
aiua-13318	117	3	and	and	CCONJ
aiua-13318	117	4	v89l	v89l	PROPN
aiua-13318	117	5	are	be	AUX
aiua-13318	117	6	the	the	DET
aiua-13318	117	7	polymorphism	polymorphism	NOUN
aiua-13318	117	8	of	of	ADP
aiua-13318	117	9	the	the	DET
aiua-13318	117	10	gene	gene	NOUN
aiua-13318	117	11	involved	involve	VERB
aiua-13318	117	12	.	.	PUNCT
aiua-13318	118	1	ninboth	ninboth	ADJ
aiua-13318	118	2	polymorphism	polymorphism	NOUN
aiua-13318	118	3	varies	vary	VERB
aiua-13318	118	4	in	in	ADP
aiua-13318	118	5	different	different	ADJ
aiua-13318	118	6	ethnic	ethnic	ADJ
aiua-13318	118	7	populations	population	NOUN
aiua-13318	118	8	.	.	PUNCT
aiua-13318	119	1	further	further	ADJ
aiua-13318	119	2	studies	study	NOUN
aiua-13318	119	3	are	be	AUX
aiua-13318	119	4	required	require	VERB
aiua-13318	119	5	to	to	PART
aiua-13318	119	6	evaluate	evaluate	VERB
aiua-13318	119	7	different	different	ADJ
aiua-13318	119	8	risk	risk	NOUN
aiua-13318	119	9	factors	factor	NOUN
aiua-13318	119	10	and	and	CCONJ
aiua-13318	119	11	outcomes	outcome	NOUN
aiua-13318	119	12	after	after	ADP
aiua-13318	119	13	medical	medical	ADJ
aiua-13318	119	14	treatment	treatment	NOUN
aiua-13318	119	15	in	in	ADP
aiua-13318	119	16	different	different	ADJ
aiua-13318	119	17	geographical	geographical	ADJ
aiua-13318	119	18	situation	situation	NOUN
aiua-13318	119	19	in	in	ADP
aiua-13318	119	20	order	order	NOUN
aiua-13318	119	21	to	to	PART
aiua-13318	119	22	provide	provide	VERB
aiua-13318	119	23	a	a	DET
aiua-13318	119	24	better	well	ADJ
aiua-13318	119	25	theoretical	theoretical	ADJ
aiua-13318	119	26	basis	basis	NOUN
aiua-13318	119	27	to	to	PART
aiua-13318	119	28	study	study	VERB
aiua-13318	119	29	the	the	DET
aiua-13318	119	30	role	role	NOUN
aiua-13318	119	31	of	of	ADP
aiua-13318	119	32	genetic	genetic	ADJ
aiua-13318	119	33	in	in	ADP
aiua-13318	119	34	the	the	DET
aiua-13318	119	35	pathogenesis	pathogenesis	NOUN
aiua-13318	119	36	of	of	ADP
aiua-13318	119	37	bph	bph	NOUN
aiua-13318	119	38	and	and	CCONJ
aiua-13318	119	39	prostate	prostate	NOUN
aiua-13318	119	40	cancer	cancer	NOUN
aiua-13318	119	41	.	.	PUNCT
aiua-13318	120	1	references	reference	NOUN
aiua-13318	120	2	1	1	NUM
aiua-13318	120	3	.	.	PUNCT
aiua-13318	120	4	roehrborn	roehrborn	ADJ
aiua-13318	120	5	cg	cg	NOUN
aiua-13318	120	6	.	.	PUNCT
aiua-13318	121	1	benign	benign	ADJ
aiua-13318	121	2	prostatic	prostatic	ADJ
aiua-13318	121	3	hyperplasia	hyperplasia	NOUN
aiua-13318	121	4	:	:	PUNCT
aiua-13318	121	5	an	an	DET
aiua-13318	121	6	overview	overview	NOUN
aiua-13318	121	7	.	.	PUNCT
aiua-13318	122	1	rev	rev	PROPN
aiua-13318	122	2	urol	urol	PROPN
aiua-13318	122	3	.	.	PUNCT
aiua-13318	122	4	2005	2005	NUM
aiua-13318	122	5	;	;	PUNCT
aiua-13318	122	6	7(suppl	7(suppl	NUM
aiua-13318	122	7	9):s3	9):s3	NUM
aiua-13318	122	8	-	-	PUNCT
aiua-13318	122	9	s14	s14	NOUN
aiua-13318	122	10	.	.	PUNCT
aiua-13318	123	1	2	2	X
aiua-13318	123	2	.	.	X
aiua-13318	123	3	goodarzi	goodarzi	PROPN
aiua-13318	123	4	d	d	PROPN
aiua-13318	123	5	,	,	PUNCT
aiua-13318	123	6	cyrus	cyrus	PROPN
aiua-13318	123	7	a	a	X
aiua-13318	123	8	,	,	PUNCT
aiua-13318	123	9	khoddami	khoddami	PROPN
aiua-13318	123	10	vishteh	vishteh	PROPN
aiua-13318	123	11	hr	hr	PROPN
aiua-13318	123	12	,	,	PUNCT
aiua-13318	123	13	et	et	PROPN
aiua-13318	123	14	al	al	PROPN
aiua-13318	123	15	.	.	PROPN
aiua-13318	123	16	effect	effect	NOUN
aiua-13318	123	17	of	of	ADP
aiua-13318	123	18	celecoxib	celecoxib	NOUN
aiua-13318	123	19	on	on	ADP
aiua-13318	123	20	benign	benign	ADJ
aiua-13318	123	21	prostatic	prostatic	ADJ
aiua-13318	123	22	hyperplasia	hyperplasia	NOUN
aiua-13318	123	23	:	:	PUNCT
aiua-13318	123	24	results	result	NOUN
aiua-13318	123	25	of	of	ADP
aiua-13318	123	26	a	a	DET
aiua-13318	123	27	preliminary	preliminary	ADJ
aiua-13318	123	28	study	study	NOUN
aiua-13318	123	29	.	.	PUNCT
aiua-13318	124	1	urological	urological	ADJ
aiua-13318	124	2	science	science	NOUN
aiua-13318	124	3	.	.	PUNCT
aiua-13318	125	1	2011	2011	NUM
aiua-13318	125	2	;	;	PUNCT
aiua-13318	126	1	22:147	22:147	NUM
aiua-13318	126	2	-	-	SYM
aiua-13318	126	3	150	150	NUM
aiua-13318	126	4	.	.	PUNCT
aiua-13318	127	1	3	3	X
aiua-13318	127	2	.	.	X
aiua-13318	127	3	middleton	middleton	PROPN
aiua-13318	127	4	lw	lw	PROPN
aiua-13318	127	5	,	,	PUNCT
aiua-13318	127	6	shen	shen	PROPN
aiua-13318	127	7	z	z	PROPN
aiua-13318	127	8	,	,	PUNCT
aiua-13318	127	9	varma	varma	PROPN
aiua-13318	127	10	s	s	PROPN
aiua-13318	127	11	,	,	PUNCT
aiua-13318	127	12	et	et	PROPN
aiua-13318	127	13	al	al	PROPN
aiua-13318	127	14	.	.	PUNCT
aiua-13318	128	1	genomic	genomic	ADJ
aiua-13318	128	2	analysis	analysis	NOUN
aiua-13318	128	3	of	of	ADP
aiua-13318	128	4	benign	benign	ADJ
aiua-13318	128	5	prostatic	prostatic	ADJ
aiua-13318	128	6	hyperplasia	hyperplasia	NOUN
aiua-13318	128	7	implicates	implicate	VERB
aiua-13318	128	8	cellular	cellular	ADJ
aiua-13318	128	9	re	re	NOUN
aiua-13318	128	10	-	-	NOUN
aiua-13318	128	11	landscaping	landscaping	NOUN
aiua-13318	128	12	in	in	ADP
aiua-13318	128	13	disease	disease	NOUN
aiua-13318	128	14	pathogenesis	pathogenesis	NOUN
aiua-13318	128	15	.	.	PUNCT
aiua-13318	129	1	jci	jci	PROPN
aiua-13318	129	2	insight	insight	PROPN
aiua-13318	129	3	.	.	PUNCT
aiua-13318	130	1	2019	2019	NUM
aiua-13318	130	2	;	;	PUNCT
aiua-13318	130	3	5	5	NUM
aiua-13318	130	4	:	:	PUNCT
aiua-13318	130	5	e129749	e129749	NOUN
aiua-13318	130	6	.	.	NOUN
aiua-13318	131	1	4	4	NUM
aiua-13318	131	2	.	.	X
aiua-13318	131	3	li	li	PROPN
aiua-13318	132	1	q	q	PROPN
aiua-13318	132	2	,	,	PUNCT
aiua-13318	132	3	zhu	zhu	PROPN
aiua-13318	132	4	y	y	PROPN
aiua-13318	132	5	,	,	PUNCT
aiua-13318	132	6	he	he	PRON
aiua-13318	132	7	j	j	PROPN
aiua-13318	132	8	,	,	PUNCT
aiua-13318	132	9	et	et	PROPN
aiua-13318	132	10	al	al	PROPN
aiua-13318	132	11	.	.	PUNCT
aiua-13318	133	1	steroid	steroid	NOUN
aiua-13318	133	2	5	5	NUM
aiua-13318	133	3	-	-	PUNCT
aiua-13318	133	4	alpha	alpha	NOUN
aiua-13318	133	5	-	-	PUNCT
aiua-13318	133	6	reductase	reductase	NOUN
aiua-13318	133	7	type	type	NOUN
aiua-13318	133	8	2	2	NUM
aiua-13318	133	9	(	(	PUNCT
aiua-13318	133	10	srd5a2	srd5a2	NOUN
aiua-13318	133	11	)	)	PUNCT
aiua-13318	133	12	declarations	declaration	NOUN
aiua-13318	133	13	ethical	ethical	ADJ
aiua-13318	133	14	approval	approval	NOUN
aiua-13318	133	15	:	:	PUNCT
aiua-13318	133	16	not	not	PART
aiua-13318	133	17	applicable	applicable	ADJ
aiua-13318	133	18	.	.	PUNCT
aiua-13318	134	1	availability	availability	NOUN
aiua-13318	134	2	of	of	ADP
aiua-13318	134	3	data	datum	NOUN
aiua-13318	134	4	and	and	CCONJ
aiua-13318	134	5	material	material	NOUN
aiua-13318	134	6	:	:	PUNCT
aiua-13318	134	7	all	all	DET
aiua-13318	134	8	inquiries	inquiry	NOUN
aiua-13318	134	9	can	can	AUX
aiua-13318	134	10	be	be	AUX
aiua-13318	134	11	directed	direct	VERB
aiua-13318	134	12	to	to	ADP
aiua-13318	134	13	the	the	DET
aiua-13318	134	14	corresponding	corresponding	ADJ
aiua-13318	134	15	author	author	NOUN
aiua-13318	134	16	.	.	PUNCT
aiua-13318	135	1	competing	compete	VERB
aiua-13318	135	2	interests	interest	NOUN
aiua-13318	135	3	:	:	PUNCT
aiua-13318	135	4	the	the	DET
aiua-13318	135	5	authors	author	NOUN
aiua-13318	135	6	declare	declare	VERB
aiua-13318	135	7	that	that	SCONJ
aiua-13318	135	8	they	they	PRON
aiua-13318	135	9	have	have	VERB
aiua-13318	135	10	no	no	DET
aiua-13318	135	11	competing	compete	VERB
aiua-13318	135	12	interests	interest	NOUN
aiua-13318	135	13	.	.	PUNCT
aiua-13318	136	1	funding	funding	NOUN
aiua-13318	136	2	:	:	PUNCT
aiua-13318	136	3	the	the	DET
aiua-13318	136	4	authors	author	NOUN
aiua-13318	136	5	report	report	VERB
aiua-13318	136	6	no	no	DET
aiua-13318	136	7	funding	funding	NOUN
aiua-13318	136	8	.	.	PUNCT
aiua-13318	137	1	authors	author	NOUN
aiua-13318	137	2	'	'	PART
aiua-13318	137	3	contributions	contribution	NOUN
aiua-13318	137	4	:	:	PUNCT
aiua-13318	137	5	rm	rm	NOUN
aiua-13318	137	6	:	:	PUNCT
aiua-13318	137	7	conceptualization	conceptualization	NOUN
aiua-13318	137	8	,	,	PUNCT
aiua-13318	137	9	methodology	methodology	NOUN
aiua-13318	137	10	,	,	PUNCT
aiua-13318	137	11	writing	writing	NOUN
aiua-13318	137	12	-	-	PUNCT
aiua-13318	137	13	original	original	ADJ
aiua-13318	137	14	draft	draft	NOUN
aiua-13318	137	15	,	,	PUNCT
aiua-13318	137	16	data	data	NOUN
aiua-13318	137	17	curation	curation	NOUN
aiua-13318	137	18	,	,	PUNCT
aiua-13318	137	19	visualization	visualization	NOUN
aiua-13318	137	20	,	,	PUNCT
aiua-13318	137	21	project	project	NOUN
aiua-13318	137	22	administration	administration	NOUN
aiua-13318	137	23	;	;	PUNCT
aiua-13318	137	24	hl	hl	NOUN
aiua-13318	137	25	:	:	PUNCT
aiua-13318	137	26	conceptualization	conceptualization	NOUN
aiua-13318	137	27	,	,	PUNCT
aiua-13318	137	28	methodology	methodology	NOUN
aiua-13318	137	29	,	,	PUNCT
aiua-13318	137	30	writingoriginal	writingoriginal	ADJ
aiua-13318	137	31	draft	draft	NOUN
aiua-13318	137	32	;	;	PUNCT
aiua-13318	137	33	pmd	pmd	NOUN
aiua-13318	137	34	:	:	PUNCT
aiua-13318	137	35	conceptualization	conceptualization	NOUN
aiua-13318	137	36	,	,	PUNCT
aiua-13318	137	37	methodology	methodology	NOUN
aiua-13318	137	38	,	,	PUNCT
aiua-13318	137	39	writingoriginal	writingoriginal	ADJ
aiua-13318	137	40	draft	draft	NOUN
aiua-13318	137	41	,	,	PUNCT
aiua-13318	137	42	investigation	investigation	NOUN
aiua-13318	137	43	;	;	PUNCT
aiua-13318	137	44	dy	dy	NOUN
aiua-13318	137	45	:	:	PUNCT
aiua-13318	137	46	conceptualization	conceptualization	NOUN
aiua-13318	137	47	,	,	PUNCT
aiua-13318	137	48	formal	formal	ADJ
aiua-13318	137	49	analysis	analysis	NOUN
aiua-13318	137	50	,	,	PUNCT
aiua-13318	137	51	na	na	NOUN
aiua-13318	137	52	:	:	PUNCT
aiua-13318	137	53	methodology	methodology	NOUN
aiua-13318	137	54	,	,	PUNCT
aiua-13318	137	55	writing	write	VERB
aiua-13318	137	56	review	review	NOUN
aiua-13318	137	57	&	&	CCONJ
aiua-13318	137	58	editing	editing	NOUN
aiua-13318	137	59	,	,	PUNCT
aiua-13318	137	60	methodology	methodology	NOUN
aiua-13318	137	61	;	;	PUNCT
aiua-13318	137	62	bd	bd	PROPN
aiua-13318	137	63	:	:	PUNCT
aiua-13318	137	64	writing	write	VERB
aiua-13318	137	65	review	review	NOUN
aiua-13318	137	66	&	&	CCONJ
aiua-13318	137	67	editing	editing	NOUN
aiua-13318	137	68	,	,	PUNCT
aiua-13318	137	69	supervision	supervision	NOUN
aiua-13318	137	70	,	,	PUNCT
aiua-13318	137	71	validation	validation	NOUN
aiua-13318	137	72	.	.	PUNCT
aiua-13318	138	1	acknowledgments	acknowledgment	NOUN
aiua-13318	138	2	:	:	PUNCT
aiua-13318	138	3	not	not	PART
aiua-13318	138	4	applicable	applicable	ADJ
aiua-13318	138	5	.	.	PUNCT
aiua-13318	139	1	consent	consent	NOUN
aiua-13318	139	2	for	for	ADP
aiua-13318	139	3	publication	publication	NOUN
aiua-13318	139	4	:	:	PUNCT
aiua-13318	139	5	not	not	PART
aiua-13318	139	6	applicable	applicable	ADJ
aiua-13318	139	7	.	.	PUNCT
aiua-13318	140	1	archivio	archivio	NOUN
aiua-13318	140	2	italiano	italiano	PROPN
aiua-13318	140	3	di	di	PROPN
aiua-13318	140	4	urologia	urologia	PROPN
aiua-13318	140	5	e	e	PROPN
aiua-13318	140	6	andrologia	andrologia	NOUN
aiua-13318	140	7	2025	2025	NUM
aiua-13318	140	8	;	;	PUNCT
aiua-13318	140	9	97(1):13318	97(1):13318	PROPN
aiua-13318	140	10	r.	r.	PROPN
aiua-13318	140	11	maharani	maharani	PROPN
aiua-13318	140	12	,	,	PUNCT
aiua-13318	140	13	h.	h.	PROPN
aiua-13318	140	14	lestari	lestari	PROPN
aiua-13318	140	15	,	,	PUNCT
aiua-13318	140	16	p.	p.	PROPN
aiua-13318	140	17	mahakarya	mahakarya	PROPN
aiua-13318	140	18	dewa	dewa	PROPN
aiua-13318	140	19	,	,	PUNCT
aiua-13318	140	20	et	et	PROPN
aiua-13318	140	21	al	al	PROPN
aiua-13318	140	22	.	.	PROPN
aiua-13318	140	23	8	8	NUM
aiua-13318	140	24	v89l	v89l	NUM
aiua-13318	140	25	and	and	CCONJ
aiua-13318	140	26	a49	a49	PROPN
aiua-13318	140	27	t	t	PROPN
aiua-13318	140	28	polymorphisms	polymorphism	NOUN
aiua-13318	140	29	and	and	CCONJ
aiua-13318	140	30	sporadic	sporadic	ADJ
aiua-13318	140	31	prostate	prostate	NOUN
aiua-13318	140	32	cancer	cancer	NOUN
aiua-13318	140	33	risk	risk	NOUN
aiua-13318	140	34	:	:	PUNCT
aiua-13318	140	35	a	a	DET
aiua-13318	140	36	meta	meta	ADJ
aiua-13318	140	37	-	-	PUNCT
aiua-13318	140	38	analysis	analysis	NOUN
aiua-13318	140	39	.	.	PUNCT
aiua-13318	141	1	molecular	molecular	ADJ
aiua-13318	141	2	biology	biology	NOUN
aiua-13318	141	3	reports	report	VERB
aiua-13318	141	4	2013	2013	NUM
aiua-13318	141	5	;	;	PUNCT
aiua-13318	141	6	40:3597	40:3597	PROPN
aiua-13318	141	7	-	-	SYM
aiua-13318	141	8	3608	3608	NUM
aiua-13318	141	9	.	.	PUNCT
aiua-13318	142	1	5	5	X
aiua-13318	142	2	.	.	X
aiua-13318	142	3	choubey	choubey	PROPN
aiua-13318	142	4	vk	vk	PROPN
aiua-13318	142	5	,	,	PUNCT
aiua-13318	142	6	sankhwar	sankhwar	PROPN
aiua-13318	142	7	sn	sn	PROPN
aiua-13318	142	8	,	,	PUNCT
aiua-13318	142	9	carlus	carlus	PROPN
aiua-13318	142	10	sj	sj	PROPN
aiua-13318	142	11	,	,	PUNCT
aiua-13318	142	12	et	et	PROPN
aiua-13318	142	13	al	al	PROPN
aiua-13318	142	14	.	.	PUNCT
aiua-13318	143	1	srd5a2	srd5a2	NOUN
aiua-13318	143	2	gene	gene	NOUN
aiua-13318	143	3	polymorphisms	polymorphism	NOUN
aiua-13318	143	4	and	and	CCONJ
aiua-13318	143	5	the	the	DET
aiua-13318	143	6	risk	risk	NOUN
aiua-13318	143	7	of	of	ADP
aiua-13318	143	8	benign	benign	ADJ
aiua-13318	143	9	prostatic	prostatic	ADJ
aiua-13318	143	10	hyperplasia	hyperplasia	NOUN
aiua-13318	143	11	but	but	CCONJ
aiua-13318	143	12	not	not	PART
aiua-13318	143	13	prostate	prostate	NOUN
aiua-13318	143	14	cancer	cancer	NOUN
aiua-13318	143	15	.	.	PUNCT
aiua-13318	144	1	asian	asian	PROPN
aiua-13318	144	2	pac	pac	PROPN
aiua-13318	144	3	j	j	PROPN
aiua-13318	144	4	cancer	cancer	NOUN
aiua-13318	144	5	prev	prev	NOUN
aiua-13318	144	6	.	.	PROPN
aiua-13318	144	7	2015	2015	NUM
aiua-13318	144	8	;	;	PUNCT
aiua-13318	144	9	16:1033	16:1033	NUM
aiua-13318	144	10	-	-	SYM
aiua-13318	144	11	1036	1036	NUM
aiua-13318	144	12	.	.	PUNCT
aiua-13318	145	1	6	6	NUM
aiua-13318	145	2	.	.	PUNCT
aiua-13318	145	3	salam	salam	PROPN
aiua-13318	145	4	mt	mt	PROPN
aiua-13318	145	5	,	,	PUNCT
aiua-13318	145	6	ursin	ursin	NOUN
aiua-13318	145	7	g	g	PROPN
aiua-13318	145	8	,	,	PUNCT
aiua-13318	145	9	skinner	skinner	PROPN
aiua-13318	145	10	ec	ec	PROPN
aiua-13318	145	11	,	,	PUNCT
aiua-13318	145	12	et	et	PROPN
aiua-13318	145	13	al	al	PROPN
aiua-13318	145	14	.	.	PROPN
aiua-13318	145	15	associations	association	NOUN
aiua-13318	145	16	between	between	ADP
aiua-13318	145	17	polymorphisms	polymorphism	NOUN
aiua-13318	145	18	in	in	ADP
aiua-13318	145	19	the	the	DET
aiua-13318	145	20	steroid	steroid	ADJ
aiua-13318	145	21	5	5	NUM
aiua-13318	145	22	-	-	PUNCT
aiua-13318	145	23	alpha	alpha	NOUN
aiua-13318	145	24	reductase	reductase	NOUN
aiua-13318	145	25	type	type	NOUN
aiua-13318	145	26	ii	ii	PROPN
aiua-13318	145	27	(	(	PUNCT
aiua-13318	145	28	srd5a2	srd5a2	NOUN
aiua-13318	145	29	)	)	PUNCT
aiua-13318	145	30	gene	gene	NOUN
aiua-13318	145	31	and	and	CCONJ
aiua-13318	145	32	benign	benign	ADJ
aiua-13318	145	33	prostatic	prostatic	ADJ
aiua-13318	145	34	hyperplasia	hyperplasia	NOUN
aiua-13318	145	35	and	and	CCONJ
aiua-13318	145	36	prostate	prostate	NOUN
aiua-13318	145	37	cancer	cancer	NOUN
aiua-13318	145	38	.	.	PUNCT
aiua-13318	146	1	urol	urol	PROPN
aiua-13318	146	2	oncol	oncol	PROPN
aiua-13318	146	3	.	.	PUNCT
aiua-13318	147	1	2005	2005	NUM
aiua-13318	147	2	;	;	PUNCT
aiua-13318	147	3	23:246	23:246	NUM
aiua-13318	147	4	-	-	SYM
aiua-13318	147	5	253	253	NUM
aiua-13318	147	6	.	.	PUNCT
aiua-13318	148	1	7	7	X
aiua-13318	148	2	.	.	X
aiua-13318	148	3	zeng	zeng	PROPN
aiua-13318	148	4	xt	xt	PROPN
aiua-13318	148	5	,	,	PUNCT
aiua-13318	148	6	su	su	PROPN
aiua-13318	148	7	xj	xj	PROPN
aiua-13318	148	8	,	,	PUNCT
aiua-13318	148	9	li	li	PROPN
aiua-13318	148	10	s	s	PROPN
aiua-13318	148	11	,	,	PUNCT
aiua-13318	148	12	et	et	PROPN
aiua-13318	148	13	al	al	PROPN
aiua-13318	148	14	.	.	PROPN
aiua-13318	148	15	association	association	PROPN
aiua-13318	148	16	between	between	ADP
aiua-13318	148	17	srd5a2	srd5a2	NOUN
aiua-13318	148	18	rs523349	rs523349	NOUN
aiua-13318	148	19	and	and	CCONJ
aiua-13318	148	20	rs9282858	rs9282858	NOUN
aiua-13318	148	21	polymorphisms	polymorphism	NOUN
aiua-13318	148	22	and	and	CCONJ
aiua-13318	148	23	risk	risk	NOUN
aiua-13318	148	24	of	of	ADP
aiua-13318	148	25	benign	benign	ADJ
aiua-13318	148	26	prostatic	prostatic	ADJ
aiua-13318	148	27	hyperplasia	hyperplasia	NOUN
aiua-13318	148	28	:	:	PUNCT
aiua-13318	148	29	a	a	DET
aiua-13318	148	30	meta	meta	ADJ
aiua-13318	148	31	-	-	PUNCT
aiua-13318	148	32	analysis	analysis	NOUN
aiua-13318	148	33	.	.	PUNCT
aiua-13318	149	1	front	front	ADJ
aiua-13318	149	2	physiol	physiol	PROPN
aiua-13318	149	3	.	.	PUNCT
aiua-13318	150	1	2017	2017	NUM
aiua-13318	150	2	;	;	PUNCT
aiua-13318	151	1	8:688	8:688	NUM
aiua-13318	151	2	.	.	NOUN
aiua-13318	151	3	8	8	NUM
aiua-13318	151	4	.	.	PUNCT
aiua-13318	151	5	price	price	NOUN
aiua-13318	151	6	dk	dk	PROPN
aiua-13318	151	7	,	,	PUNCT
aiua-13318	151	8	chau	chau	NOUN
aiua-13318	151	9	ch	ch	NOUN
aiua-13318	151	10	,	,	PUNCT
aiua-13318	151	11	till	till	SCONJ
aiua-13318	151	12	c	c	X
aiua-13318	151	13	,	,	PUNCT
aiua-13318	151	14	et	et	PROPN
aiua-13318	151	15	al	al	PROPN
aiua-13318	151	16	.	.	PROPN
aiua-13318	151	17	association	association	PROPN
aiua-13318	151	18	of	of	ADP
aiua-13318	151	19	androgen	androgen	NOUN
aiua-13318	151	20	metabolism	metabolism	NOUN
aiua-13318	151	21	gene	gene	NOUN
aiua-13318	151	22	polymorphisms	polymorphism	NOUN
aiua-13318	151	23	with	with	ADP
aiua-13318	151	24	prostate	prostate	NOUN
aiua-13318	151	25	cancer	cancer	NOUN
aiua-13318	151	26	risk	risk	NOUN
aiua-13318	151	27	and	and	CCONJ
aiua-13318	151	28	androgen	androgen	NOUN
aiua-13318	151	29	concentrations	concentration	NOUN
aiua-13318	151	30	:	:	PUNCT
aiua-13318	151	31	results	result	NOUN
aiua-13318	151	32	from	from	ADP
aiua-13318	151	33	the	the	DET
aiua-13318	151	34	prostate	prostate	NOUN
aiua-13318	151	35	cancer	cancer	NOUN
aiua-13318	151	36	prevention	prevention	NOUN
aiua-13318	151	37	trial	trial	NOUN
aiua-13318	151	38	.	.	PUNCT
aiua-13318	152	1	cancer	cancer	NOUN
aiua-13318	152	2	.	.	PUNCT
aiua-13318	153	1	2016	2016	NUM
aiua-13318	153	2	;	;	PUNCT
aiua-13318	153	3	122:2332	122:2332	NUM
aiua-13318	153	4	-	-	SYM
aiua-13318	153	5	2340	2340	NUM
aiua-13318	153	6	.	.	PUNCT
aiua-13318	154	1	9	9	NUM
aiua-13318	154	2	.	.	X
aiua-13318	154	3	elzanaty	elzanaty	PROPN
aiua-13318	154	4	s	s	PART
aiua-13318	154	5	,	,	PUNCT
aiua-13318	154	6	giwercman	giwercman	ADJ
aiua-13318	154	7	yl	yl	NOUN
aiua-13318	154	8	,	,	PUNCT
aiua-13318	154	9	giwercman	giwercman	ADJ
aiua-13318	154	10	a.	a.	NOUN
aiua-13318	154	11	significant	significant	ADJ
aiua-13318	154	12	impact	impact	NOUN
aiua-13318	154	13	of	of	ADP
aiua-13318	154	14	5alpha	5alpha	NUM
aiua-13318	154	15	-	-	PUNCT
aiua-13318	154	16	reductase	reductase	NOUN
aiua-13318	154	17	type	type	NOUN
aiua-13318	154	18	2	2	NUM
aiua-13318	154	19	polymorphisms	polymorphism	NOUN
aiua-13318	154	20	on	on	ADP
aiua-13318	154	21	sperm	sperm	NOUN
aiua-13318	154	22	concentration	concentration	NOUN
aiua-13318	154	23	and	and	CCONJ
aiua-13318	154	24	motility	motility	NOUN
aiua-13318	154	25	.	.	PUNCT
aiua-13318	155	1	int	int	PROPN
aiua-13318	156	1	j	j	PROPN
aiua-13318	156	2	androl	androl	PROPN
aiua-13318	156	3	.	.	PUNCT
aiua-13318	156	4	2006	2006	NUM
aiua-13318	156	5	;	;	PUNCT
aiua-13318	156	6	29:414	29:414	NUM
aiua-13318	156	7	-	-	SYM
aiua-13318	156	8	20	20	NUM
aiua-13318	156	9	.	.	PUNCT
aiua-13318	156	10	10	10	NUM
aiua-13318	156	11	.	.	PUNCT
aiua-13318	157	1	neslund	neslund	NOUN
aiua-13318	157	2	-	-	PUNCT
aiua-13318	157	3	dudas	dudas	PROPN
aiua-13318	157	4	c	c	NOUN
aiua-13318	157	5	,	,	PUNCT
aiua-13318	157	6	bock	bock	NOUN
aiua-13318	157	7	ch	ch	NOUN
aiua-13318	157	8	,	,	PUNCT
aiua-13318	157	9	monaghan	monaghan	PROPN
aiua-13318	157	10	k	k	PROPN
aiua-13318	157	11	,	,	PUNCT
aiua-13318	157	12	et	et	PROPN
aiua-13318	157	13	al	al	PROPN
aiua-13318	157	14	.	.	PUNCT
aiua-13318	158	1	srd5a2	srd5a2	NOUN
aiua-13318	158	2	and	and	CCONJ
aiua-13318	158	3	hsd3b2	hsd3b2	PRON
aiua-13318	158	4	polymorphisms	polymorphism	NOUN
aiua-13318	158	5	are	be	AUX
aiua-13318	158	6	associated	associate	VERB
aiua-13318	158	7	with	with	ADP
aiua-13318	158	8	prostate	prostate	NOUN
aiua-13318	158	9	cancer	cancer	NOUN
aiua-13318	158	10	risk	risk	NOUN
aiua-13318	158	11	and	and	CCONJ
aiua-13318	158	12	aggressiveness	aggressiveness	NOUN
aiua-13318	158	13	.	.	PUNCT
aiua-13318	159	1	prostate	prostate	NOUN
aiua-13318	159	2	2007	2007	NUM
aiua-13318	159	3	;	;	PUNCT
aiua-13318	159	4	67:1654	67:1654	X
aiua-13318	159	5	-	-	SYM
aiua-13318	159	6	1663	1663	NUM
aiua-13318	159	7	.	.	PUNCT
aiua-13318	160	1	11	11	NUM
aiua-13318	160	2	.	.	PUNCT
aiua-13318	160	3	allen	allen	PROPN
aiua-13318	160	4	ne	ne	PROPN
aiua-13318	160	5	,	,	PUNCT
aiua-13318	160	6	forrest	forrest	PROPN
aiua-13318	160	7	ms	ms	PROPN
aiua-13318	160	8	,	,	PUNCT
aiua-13318	160	9	key	key	ADJ
aiua-13318	160	10	tj	tj	NOUN
aiua-13318	160	11	.	.	PUNCT
aiua-13318	161	1	the	the	DET
aiua-13318	161	2	association	association	NOUN
aiua-13318	161	3	between	between	ADP
aiua-13318	161	4	polymorphisms	polymorphism	NOUN
aiua-13318	161	5	in	in	ADP
aiua-13318	161	6	the	the	DET
aiua-13318	161	7	cyp17	cyp17	NOUN
aiua-13318	161	8	and	and	CCONJ
aiua-13318	161	9	5α	5α	ADJ
aiua-13318	161	10	-	-	PUNCT
aiua-13318	161	11	reductase	reductase	NOUN
aiua-13318	161	12	(	(	PUNCT
aiua-13318	161	13	srd5a2	srd5a2	NOUN
aiua-13318	161	14	)	)	PUNCT
aiua-13318	161	15	genes	gene	NOUN
aiua-13318	161	16	and	and	CCONJ
aiua-13318	161	17	serum	serum	NOUN
aiua-13318	161	18	androgen	androgen	NOUN
aiua-13318	161	19	concentrations	concentration	NOUN
aiua-13318	161	20	in	in	ADP
aiua-13318	161	21	men	man	NOUN
aiua-13318	161	22	.	.	PUNCT
aiua-13318	162	1	cancer	cancer	NOUN
aiua-13318	162	2	epidemiol	epidemiol	PROPN
aiua-13318	162	3	biomarkers	biomarkers	PROPN
aiua-13318	162	4	prev	prev	X
aiua-13318	162	5	.	.	PUNCT
aiua-13318	163	1	2001	2001	NUM
aiua-13318	163	2	;	;	PUNCT
aiua-13318	163	3	10:185	10:185	NUM
aiua-13318	163	4	-	-	SYM
aiua-13318	163	5	9	9	NUM
aiua-13318	163	6	.	.	NOUN
aiua-13318	163	7	12	12	NUM
aiua-13318	163	8	.	.	PUNCT
aiua-13318	164	1	van	van	PROPN
aiua-13318	164	2	gils	gils	PROPN
aiua-13318	164	3	ch	ch	NOUN
aiua-13318	164	4	,	,	PUNCT
aiua-13318	164	5	onland	onland	NOUN
aiua-13318	164	6	-	-	PUNCT
aiua-13318	164	7	moret	moret	NOUN
aiua-13318	164	8	nc	nc	PROPN
aiua-13318	164	9	,	,	PUNCT
aiua-13318	164	10	roest	ro	ADJ
aiua-13318	164	11	m	m	PROPN
aiua-13318	164	12	,	,	PUNCT
aiua-13318	164	13	et	et	PROPN
aiua-13318	164	14	al	al	PROPN
aiua-13318	164	15	.	.	PUNCT
aiua-13318	165	1	the	the	DET
aiua-13318	165	2	v89l	v89l	PROPN
aiua-13318	165	3	polymorphism	polymorphism	NOUN
aiua-13318	165	4	in	in	ADP
aiua-13318	165	5	the	the	DET
aiua-13318	165	6	5	5	NUM
aiua-13318	165	7	-	-	PUNCT
aiua-13318	165	8	α	α	NUM
aiua-13318	165	9	-	-	PUNCT
aiua-13318	165	10	reductase	reductase	NOUN
aiua-13318	165	11	type	type	NOUN
aiua-13318	165	12	2	2	NUM
aiua-13318	165	13	gene	gene	NOUN
aiua-13318	165	14	and	and	CCONJ
aiua-13318	165	15	risk	risk	NOUN
aiua-13318	165	16	of	of	ADP
aiua-13318	165	17	breast	breast	NOUN
aiua-13318	165	18	cancer	cancer	NOUN
aiua-13318	165	19	.	.	PUNCT
aiua-13318	166	1	cancer	cancer	NOUN
aiua-13318	166	2	epidemiol	epidemiol	PROPN
aiua-13318	166	3	biomarkers	biomarkers	PROPN
aiua-13318	166	4	prev	prev	X
aiua-13318	166	5	.	.	PUNCT
aiua-13318	167	1	2003	2003	NUM
aiua-13318	167	2	;	;	PUNCT
aiua-13318	167	3	12:1194	12:1194	NUM
aiua-13318	167	4	-	-	SYM
aiua-13318	167	5	9	9	NUM
aiua-13318	167	6	.	.	NOUN
aiua-13318	167	7	13	13	NUM
aiua-13318	167	8	.	.	PUNCT
aiua-13318	168	1	wang	wang	PROPN
aiua-13318	168	2	c	c	PROPN
aiua-13318	168	3	,	,	PUNCT
aiua-13318	168	4	tao	tao	PROPN
aiua-13318	168	5	w	w	PROPN
aiua-13318	168	6	,	,	PUNCT
aiua-13318	168	7	chen	chen	PROPN
aiua-13318	168	8	q	q	PROPN
aiua-13318	168	9	,	,	PUNCT
aiua-13318	168	10	et	et	PROPN
aiua-13318	168	11	al	al	PROPN
aiua-13318	168	12	.	.	PUNCT
aiua-13318	169	1	srd5a2	srd5a2	PROPN
aiua-13318	169	2	v89l	v89l	X
aiua-13318	169	3	polymorphism	polymorphism	NOUN
aiua-13318	169	4	and	and	CCONJ
aiua-13318	169	5	prostate	prostate	NOUN
aiua-13318	169	6	cancer	cancer	NOUN
aiua-13318	169	7	risk	risk	NOUN
aiua-13318	169	8	:	:	PUNCT
aiua-13318	169	9	a	a	DET
aiua-13318	169	10	meta	meta	ADJ
aiua-13318	169	11	-	-	PUNCT
aiua-13318	169	12	analysis	analysis	NOUN
aiua-13318	169	13	.	.	PUNCT
aiua-13318	170	1	prostate	prostate	NOUN
aiua-13318	170	2	.	.	PUNCT
aiua-13318	171	1	2010	2010	NUM
aiua-13318	171	2	;	;	PUNCT
aiua-13318	171	3	70:170	70:170	NUM
aiua-13318	171	4	-	-	SYM
aiua-13318	171	5	8	8	NUM
aiua-13318	171	6	.	.	PUNCT
aiua-13318	172	1	14	14	NUM
aiua-13318	172	2	.	.	PUNCT
aiua-13318	173	1	li	li	PROPN
aiua-13318	173	2	j	j	PROPN
aiua-13318	173	3	,	,	PUNCT
aiua-13318	173	4	coates	coates	PROPN
aiua-13318	173	5	rj	rj	PROPN
aiua-13318	173	6	,	,	PUNCT
aiua-13318	173	7	gwinn	gwinn	PROPN
aiua-13318	173	8	m	m	PROPN
aiua-13318	173	9	,	,	PUNCT
aiua-13318	173	10	khoury	khoury	PROPN
aiua-13318	173	11	mj	mj	PROPN
aiua-13318	173	12	.	.	PUNCT
aiua-13318	174	1	steroid	steroid	PROPN
aiua-13318	174	2	5	5	NUM
aiua-13318	174	3	-	-	PUNCT
aiua-13318	174	4	α	α	NUM
aiua-13318	174	5	-	-	PUNCT
aiua-13318	174	6	reductase	reductase	NOUN
aiua-13318	174	7	type	type	NOUN
aiua-13318	174	8	2	2	NUM
aiua-13318	174	9	(	(	PUNCT
aiua-13318	174	10	srd5a2	srd5a2	NOUN
aiua-13318	174	11	)	)	PUNCT
aiua-13318	174	12	gene	gene	NOUN
aiua-13318	174	13	polymorphisms	polymorphism	NOUN
aiua-13318	174	14	and	and	CCONJ
aiua-13318	174	15	risk	risk	NOUN
aiua-13318	174	16	of	of	ADP
aiua-13318	174	17	prostate	prostate	NOUN
aiua-13318	174	18	cancer	cancer	NOUN
aiua-13318	174	19	:	:	PUNCT
aiua-13318	174	20	a	a	DET
aiua-13318	174	21	huge	huge	ADJ
aiua-13318	174	22	review	review	NOUN
aiua-13318	174	23	.	.	PUNCT
aiua-13318	175	1	am	be	AUX
aiua-13318	175	2	j	j	PROPN
aiua-13318	175	3	epidemiol	epidemiol	PROPN
aiua-13318	175	4	.	.	PUNCT
aiua-13318	176	1	2010	2010	NUM
aiua-13318	176	2	;	;	PUNCT
aiua-13318	176	3	171:1	171:1	NUM
aiua-13318	176	4	-	-	SYM
aiua-13318	176	5	13	13	NUM
aiua-13318	176	6	.	.	NOUN
aiua-13318	177	1	15	15	NUM
aiua-13318	177	2	.	.	PUNCT
aiua-13318	177	3	giwercman	giwercman	ADJ
aiua-13318	177	4	yl	yl	PROPN
aiua-13318	177	5	,	,	PUNCT
aiua-13318	177	6	abrahamsson	abrahamsson	PROPN
aiua-13318	177	7	pa	pa	PROPN
aiua-13318	177	8	,	,	PUNCT
aiua-13318	177	9	giwercman	giwercman	NOUN
aiua-13318	177	10	a	a	PRON
aiua-13318	177	11	,	,	PUNCT
aiua-13318	177	12	et	et	PROPN
aiua-13318	177	13	al	al	PROPN
aiua-13318	177	14	.	.	PUNCT
aiua-13318	178	1	the	the	DET
aiua-13318	178	2	5alpha	5alpha	NUM
aiua-13318	178	3	-	-	PUNCT
aiua-13318	178	4	reductase	reductase	NOUN
aiua-13318	178	5	type	type	NOUN
aiua-13318	178	6	ii	ii	PROPN
aiua-13318	178	7	a49	a49	PROPN
aiua-13318	178	8	t	t	PROPN
aiua-13318	178	9	and	and	CCONJ
aiua-13318	178	10	v89l	v89l	VERB
aiua-13318	178	11	high	high	ADJ
aiua-13318	178	12	-	-	PUNCT
aiua-13318	178	13	activity	activity	NOUN
aiua-13318	178	14	allelic	allelic	ADJ
aiua-13318	178	15	variants	variant	NOUN
aiua-13318	178	16	are	be	AUX
aiua-13318	178	17	more	more	ADV
aiua-13318	178	18	common	common	ADJ
aiua-13318	178	19	in	in	ADP
aiua-13318	178	20	men	man	NOUN
aiua-13318	178	21	with	with	ADP
aiua-13318	178	22	prostate	prostate	NOUN
aiua-13318	178	23	cancer	cancer	NOUN
aiua-13318	178	24	compared	compare	VERB
aiua-13318	178	25	with	with	ADP
aiua-13318	178	26	the	the	DET
aiua-13318	178	27	general	general	ADJ
aiua-13318	178	28	population	population	NOUN
aiua-13318	178	29	.	.	PUNCT
aiua-13318	179	1	eur	eur	PROPN
aiua-13318	179	2	urol	urol	PROPN
aiua-13318	179	3	.	.	PUNCT
aiua-13318	180	1	2005	2005	NUM
aiua-13318	180	2	;	;	PUNCT
aiua-13318	180	3	48:679	48:679	NUM
aiua-13318	180	4	-	-	SYM
aiua-13318	180	5	85	85	NUM
aiua-13318	180	6	.	.	PUNCT
aiua-13318	181	1	16	16	NUM
aiua-13318	181	2	.	.	PUNCT
aiua-13318	182	1	tekin	tekin	PROPN
aiua-13318	182	2	neijmann	neijmann	PROPN
aiua-13318	182	3	s	s	PROPN
aiua-13318	182	4	,	,	PUNCT
aiua-13318	182	5	kural	kural	ADJ
aiua-13318	182	6	a	a	X
aiua-13318	182	7	,	,	PUNCT
aiua-13318	182	8	tinay	tinay	PROPN
aiua-13318	183	1	i	i	PRON
aiua-13318	183	2	,	,	PUNCT
aiua-13318	183	3	et	et	PROPN
aiua-13318	183	4	al	al	PROPN
aiua-13318	183	5	.	.	PROPN
aiua-13318	183	6	association	association	PROPN
aiua-13318	183	7	of	of	ADP
aiua-13318	183	8	missense	missense	NOUN
aiua-13318	183	9	substitution	substitution	NOUN
aiua-13318	183	10	of	of	ADP
aiua-13318	183	11	a49	a49	PROPN
aiua-13318	183	12	t	t	PROPN
aiua-13318	183	13	and	and	CCONJ
aiua-13318	183	14	v89l	v89l	VERB
aiua-13318	183	15	in	in	ADP
aiua-13318	183	16	the	the	DET
aiua-13318	183	17	srd5a2	srd5a2	NOUN
aiua-13318	183	18	gene	gene	NOUN
aiua-13318	183	19	with	with	ADP
aiua-13318	183	20	prostate	prostate	NOUN
aiua-13318	183	21	cancer	cancer	NOUN
aiua-13318	183	22	in	in	ADP
aiua-13318	183	23	turkish	turkish	ADJ
aiua-13318	183	24	patients	patient	NOUN
aiua-13318	183	25	.	.	PUNCT
aiua-13318	184	1	turkish	turkish	ADJ
aiua-13318	184	2	journal	journal	PROPN
aiua-13318	184	3	of	of	ADP
aiua-13318	184	4	biochemistry	biochemistry	NOUN
aiua-13318	184	5	.	.	PUNCT
aiua-13318	185	1	2017	2017	NUM
aiua-13318	185	2	;	;	PUNCT
aiua-13318	185	3	42:37	42:37	NUM
aiua-13318	185	4	-	-	SYM
aiua-13318	185	5	43	43	NUM
aiua-13318	185	6	17	17	NUM
aiua-13318	185	7	.	.	PUNCT
aiua-13318	186	1	konwar	konwar	PROPN
aiua-13318	186	2	r	r	PROPN
aiua-13318	186	3	,	,	PUNCT
aiua-13318	186	4	chattopadhyay	chattopadhyay	PROPN
aiua-13318	186	5	n	n	CCONJ
aiua-13318	186	6	,	,	PUNCT
aiua-13318	186	7	bid	bid	VERB
aiua-13318	186	8	hk	hk	PROPN
aiua-13318	186	9	.	.	PUNCT
aiua-13318	187	1	genetic	genetic	ADJ
aiua-13318	187	2	polymorphism	polymorphism	NOUN
aiua-13318	187	3	and	and	CCONJ
aiua-13318	187	4	pathogenesis	pathogenesis	NOUN
aiua-13318	187	5	of	of	ADP
aiua-13318	187	6	benign	benign	ADJ
aiua-13318	187	7	prostatic	prostatic	ADJ
aiua-13318	187	8	hyperplasia	hyperplasia	NOUN
aiua-13318	187	9	(	(	PUNCT
aiua-13318	187	10	bph	bph	NOUN
aiua-13318	187	11	)	)	PUNCT
aiua-13318	187	12	.	.	PUNCT
aiua-13318	188	1	bju	bju	PROPN
aiua-13318	188	2	international	international	PROPN
aiua-13318	188	3	.	.	PUNCT
aiua-13318	188	4	2008	2008	NUM
aiua-13318	188	5	;	;	PUNCT
aiua-13318	188	6	5:536	5:536	NUM
aiua-13318	188	7	-	-	SYM
aiua-13318	188	8	44	44	NUM
aiua-13318	188	9	.	.	PUNCT
aiua-13318	189	1	18	18	NUM
aiua-13318	189	2	.	.	PUNCT
aiua-13318	190	1	lunn	lunn	PROPN
aiua-13318	190	2	rm	rm	PROPN
aiua-13318	190	3	,	,	PUNCT
aiua-13318	190	4	bell	bell	PROPN
aiua-13318	190	5	da	da	PROPN
aiua-13318	190	6	,	,	PUNCT
aiua-13318	190	7	mohler	mohler	NOUN
aiua-13318	190	8	jl	jl	PROPN
aiua-13318	190	9	,	,	PUNCT
aiua-13318	190	10	taylor	taylor	PROPN
aiua-13318	190	11	ja	ja	PROPN
aiua-13318	190	12	.	.	PUNCT
aiua-13318	190	13	prostate	prostate	NOUN
aiua-13318	190	14	cancer	cancer	NOUN
aiua-13318	190	15	risk	risk	NOUN
aiua-13318	190	16	and	and	CCONJ
aiua-13318	190	17	polymorphism	polymorphism	NOUN
aiua-13318	190	18	in	in	ADP
aiua-13318	190	19	17	17	NUM
aiua-13318	190	20	hydroxylase	hydroxylase	NOUN
aiua-13318	190	21	(	(	PUNCT
aiua-13318	190	22	cyp17	cyp17	PROPN
aiua-13318	190	23	)	)	PUNCT
aiua-13318	190	24	and	and	CCONJ
aiua-13318	190	25	steroid	steroid	NOUN
aiua-13318	190	26	reductase	reductase	NOUN
aiua-13318	190	27	(	(	PUNCT
aiua-13318	190	28	srd5a2	srd5a2	NOUN
aiua-13318	190	29	)	)	PUNCT
aiua-13318	190	30	.	.	PUNCT
aiua-13318	191	1	carcinogenesis	carcinogenesis	NOUN
aiua-13318	191	2	.	.	PUNCT
aiua-13318	191	3	1999	1999	NUM
aiua-13318	191	4	;	;	PUNCT
aiua-13318	191	5	20:1727	20:1727	NUM
aiua-13318	191	6	-	-	SYM
aiua-13318	191	7	31	31	NUM
aiua-13318	191	8	.	.	PUNCT
aiua-13318	192	1	19	19	NUM
aiua-13318	192	2	.	.	NOUN
aiua-13318	192	3	daryanto	daryanto	PROPN
aiua-13318	192	4	b	b	PROPN
aiua-13318	192	5	,	,	PUNCT
aiua-13318	192	6	naim	naim	PROPN
aiua-13318	192	7	hy	hy	PROPN
aiua-13318	192	8	,	,	PUNCT
aiua-13318	192	9	budaya	budaya	VERB
aiua-13318	192	10	tn	tn	PROPN
aiua-13318	192	11	.	.	PUNCT
aiua-13318	193	1	the	the	DET
aiua-13318	193	2	effect	effect	NOUN
aiua-13318	193	3	of	of	ADP
aiua-13318	193	4	tamsulosin	tamsulosin	NOUN
aiua-13318	193	5	,	,	PUNCT
aiua-13318	193	6	dutasteride	dutasteride	NOUN
aiua-13318	193	7	monotherapy	monotherapy	NOUN
aiua-13318	193	8	and	and	CCONJ
aiua-13318	193	9	tamsulosin	tamsulosin	NOUN
aiua-13318	193	10	-	-	PUNCT
aiua-13318	193	11	dutasteride	dutasteride	NOUN
aiua-13318	193	12	combination	combination	NOUN
aiua-13318	193	13	on	on	ADP
aiua-13318	193	14	prostate	prostate	NOUN
aiua-13318	193	15	smooth	smooth	ADJ
aiua-13318	193	16	muscle	muscle	NOUN
aiua-13318	193	17	contractility	contractility	NOUN
aiua-13318	193	18	in	in	ADP
aiua-13318	193	19	bph	bph	NOUN
aiua-13318	193	20	model	model	PROPN
aiua-13318	193	21	wistar	wistar	PROPN
aiua-13318	193	22	strain	strain	PROPN
aiua-13318	193	23	rattus	rattus	PROPN
aiua-13318	193	24	novergicus	novergicus	PROPN
aiua-13318	193	25	.	.	PUNCT
aiua-13318	194	1	medical	medical	ADJ
aiua-13318	194	2	archives	archive	NOUN
aiua-13318	194	3	.	.	PUNCT
aiua-13318	195	1	2023	2023	NUM
aiua-13318	195	2	;	;	PUNCT
aiua-13318	195	3	77:13	77:13	NUM
aiua-13318	195	4	.	.	PUNCT
aiua-13318	196	1	correspondence	correspondence	NOUN
aiua-13318	196	2	revina	revina	PROPN
aiua-13318	196	3	maharani	maharani	PROPN
aiua-13318	196	4	10maharanirevina@gmail.com	10maharanirevina@gmail.com	PROPN
aiua-13318	196	5	hotma	hotma	PROPN
aiua-13318	196	6	lestari	lestari	PROPN
aiua-13318	196	7	hotlesmo67@gmail.com	hotlesmo67@gmail.com	PROPN
aiua-13318	196	8	putra	putra	PROPN
aiua-13318	196	9	mahakarya	mahakarya	PROPN
aiua-13318	196	10	dewa	dewa	PROPN
aiua-13318	196	11	putramahakaryadewa25@gmail.com	putramahakaryadewa25@gmail.com	PROPN
aiua-13318	196	12	dewangga	dewangga	PROPN
aiua-13318	196	13	yudisthira	yudisthira	PROPN
aiua-13318	196	14	dewanggay369@gmail.com	dewanggay369@gmail.com	X
aiua-13318	196	15	nasim	nasim	PROPN
aiua-13318	196	16	amar	amar	PROPN
aiua-13318	196	17	nasemamar2003@gmail.com	nasemamar2003@gmail.com	PROPN
aiua-13318	197	1	medical	medical	ADJ
aiua-13318	197	2	faculty	faculty	NOUN
aiua-13318	197	3	,	,	PUNCT
aiua-13318	197	4	universitas	universita	NOUN
aiua-13318	197	5	brawijaya	brawijaya	PROPN
aiua-13318	197	6	,	,	PUNCT
aiua-13318	197	7	malang	malang	PROPN
aiua-13318	197	8	,	,	PUNCT
aiua-13318	197	9	indonesia	indonesia	PROPN
aiua-13318	197	10	besut	besut	PROPN
aiua-13318	197	11	daryanto	daryanto	PROPN
aiua-13318	197	12	(	(	PUNCT
aiua-13318	197	13	corresponding	correspond	VERB
aiua-13318	197	14	author	author	NOUN
aiua-13318	197	15	)	)	PUNCT
aiua-13318	197	16	urobes.fk@ub.ac.id	urobes.fk@ub.ac.id	PROPN
aiua-13318	197	17	urology	urology	NOUN
aiua-13318	197	18	department	department	NOUN
aiua-13318	197	19	,	,	PUNCT
aiua-13318	197	20	faculty	faculty	NOUN
aiua-13318	197	21	of	of	ADP
aiua-13318	197	22	medicine	medicine	NOUN
aiua-13318	197	23	universitas	universita	NOUN
aiua-13318	197	24	brawijaya	brawijaya	PROPN
aiua-13318	197	25	,	,	PUNCT
aiua-13318	197	26	dr	dr	PROPN
aiua-13318	197	27	.	.	PROPN
aiua-13318	197	28	saiful	saiful	PROPN
aiua-13318	197	29	anwar	anwar	PROPN
aiua-13318	197	30	general	general	PROPN
aiua-13318	197	31	hospital	hospital	PROPN
aiua-13318	197	32	,	,	PUNCT
aiua-13318	197	33	malang	malang	PROPN
aiua-13318	197	34	,	,	PUNCT
aiua-13318	197	35	indonesia	indonesia	PROPN