id	sid	tid	token	lemma	pos
aiua-13516	1	1	stesura	stesura	PROPN
aiua-13516	1	2	seveso	seveso	PROPN
aiua-13516	1	3	archivio	archivio	PROPN
aiua-13516	1	4	italiano	italiano	X
aiua-13516	1	5	di	di	X
aiua-13516	1	6	urologia	urologia	PROPN
aiua-13516	1	7	e	e	PROPN
aiua-13516	1	8	andrologia	andrologia	NOUN
aiua-13516	1	9	2025	2025	NUM
aiua-13516	1	10	;	;	PUNCT
aiua-13516	1	11	97(1):13516	97(1):13516	NUM
aiua-13516	1	12	1	1	NUM
aiua-13516	1	13	original	original	ADJ
aiua-13516	1	14	paper	paper	NOUN
aiua-13516	1	15	an	an	DET
aiua-13516	1	16	effective	effective	ADJ
aiua-13516	1	17	alternative	alternative	NOUN
aiua-13516	1	18	for	for	ADP
aiua-13516	1	19	advanced	advanced	ADJ
aiua-13516	1	20	blca	blca	NOUN
aiua-13516	1	21	due	due	ADP
aiua-13516	1	22	to	to	ADP
aiua-13516	1	23	their	their	PRON
aiua-13516	1	24	better	well	ADJ
aiua-13516	1	25	tolerance	tolerance	NOUN
aiua-13516	1	26	especially	especially	ADV
aiua-13516	1	27	by	by	ADP
aiua-13516	1	28	older	old	ADJ
aiua-13516	1	29	patients	patient	NOUN
aiua-13516	1	30	with	with	ADP
aiua-13516	1	31	more	more	ADJ
aiua-13516	1	32	comorbidities	comorbiditie	NOUN
aiua-13516	1	33	.	.	PUNCT
aiua-13516	2	1	however	however	ADV
aiua-13516	2	2	,	,	PUNCT
aiua-13516	2	3	despite	despite	SCONJ
aiua-13516	2	4	durable	durable	ADJ
aiua-13516	2	5	responses	response	NOUN
aiua-13516	2	6	shown	show	VERB
aiua-13516	2	7	in	in	ADP
aiua-13516	2	8	a	a	DET
aiua-13516	2	9	subset	subset	NOUN
aiua-13516	2	10	of	of	ADP
aiua-13516	2	11	patients	patient	NOUN
aiua-13516	2	12	with	with	ADP
aiua-13516	2	13	blca	blca	PROPN
aiua-13516	2	14	,	,	PUNCT
aiua-13516	2	15	the	the	DET
aiua-13516	2	16	overall	overall	ADJ
aiua-13516	2	17	response	response	NOUN
aiua-13516	2	18	rate	rate	NOUN
aiua-13516	2	19	of	of	ADP
aiua-13516	2	20	ici	ici	PROPN
aiua-13516	2	21	’s	’s	PART
aiua-13516	2	22	is	be	AUX
aiua-13516	2	23	only	only	ADV
aiua-13516	2	24	15%~25	15%~25	NUM
aiua-13516	2	25	%	%	NOUN
aiua-13516	2	26	,	,	PUNCT
aiua-13516	2	27	which	which	PRON
aiua-13516	2	28	increases	increase	VERB
aiua-13516	2	29	the	the	DET
aiua-13516	2	30	demand	demand	NOUN
aiua-13516	2	31	for	for	ADP
aiua-13516	2	32	biomarkers	biomarker	NOUN
aiua-13516	2	33	of	of	ADP
aiua-13516	2	34	response	response	NOUN
aiua-13516	2	35	and	and	CCONJ
aiua-13516	2	36	therapeutic	therapeutic	ADJ
aiua-13516	2	37	strategies	strategy	NOUN
aiua-13516	2	38	that	that	PRON
aiua-13516	2	39	can	can	AUX
aiua-13516	2	40	overcome	overcome	VERB
aiua-13516	2	41	resistance	resistance	NOUN
aiua-13516	2	42	to	to	ADP
aiua-13516	2	43	icis	icis	NOUN
aiua-13516	2	44	(	(	PUNCT
aiua-13516	2	45	4	4	NUM
aiua-13516	2	46	,	,	PUNCT
aiua-13516	2	47	5	5	NUM
aiua-13516	2	48	)	)	PUNCT
aiua-13516	2	49	.	.	PUNCT
aiua-13516	3	1	lactylation	lactylation	PROPN
aiua-13516	3	2	modification	modification	NOUN
aiua-13516	3	3	has	have	AUX
aiua-13516	3	4	been	be	AUX
aiua-13516	3	5	well	well	ADV
aiua-13516	3	6	studied	study	VERB
aiua-13516	3	7	for	for	ADP
aiua-13516	3	8	its	its	PRON
aiua-13516	3	9	potential	potential	ADJ
aiua-13516	3	10	role	role	NOUN
aiua-13516	3	11	in	in	ADP
aiua-13516	3	12	cancer	cancer	NOUN
aiua-13516	3	13	progression	progression	NOUN
aiua-13516	3	14	(	(	PUNCT
aiua-13516	3	15	6	6	NUM
aiua-13516	3	16	-	-	SYM
aiua-13516	3	17	8)	8)	NUM
aiua-13516	3	18	.	.	PUNCT
aiua-13516	4	1	the	the	DET
aiua-13516	4	2	tumor	tumor	NOUN
aiua-13516	4	3	microenvironment	microenvironment	NOUN
aiua-13516	4	4	is	be	AUX
aiua-13516	4	5	characterized	characterize	VERB
aiua-13516	4	6	by	by	ADP
aiua-13516	4	7	low	low	ADJ
aiua-13516	4	8	ph	ph	ADJ
aiua-13516	4	9	,	,	PUNCT
aiua-13516	4	10	hypoxia	hypoxia	NOUN
aiua-13516	4	11	,	,	PUNCT
aiua-13516	4	12	and	and	CCONJ
aiua-13516	4	13	increased	increase	VERB
aiua-13516	4	14	lactate	lactate	NOUN
aiua-13516	4	15	production	production	NOUN
aiua-13516	4	16	.	.	PUNCT
aiua-13516	5	1	lactate	lactate	PROPN
aiua-13516	5	2	,	,	PUNCT
aiua-13516	5	3	a	a	DET
aiua-13516	5	4	product	product	NOUN
aiua-13516	5	5	of	of	ADP
aiua-13516	5	6	pyruvate	pyruvate	NOUN
aiua-13516	5	7	metabolism	metabolism	NOUN
aiua-13516	5	8	,	,	PUNCT
aiua-13516	5	9	is	be	AUX
aiua-13516	5	10	known	know	VERB
aiua-13516	5	11	to	to	PART
aiua-13516	5	12	play	play	VERB
aiua-13516	5	13	an	an	DET
aiua-13516	5	14	important	important	ADJ
aiua-13516	5	15	role	role	NOUN
aiua-13516	5	16	in	in	ADP
aiua-13516	5	17	promoting	promote	VERB
aiua-13516	5	18	tumor	tumor	NOUN
aiua-13516	5	19	growth	growth	NOUN
aiua-13516	5	20	and	and	CCONJ
aiua-13516	5	21	metastasis	metastasis	NOUN
aiua-13516	5	22	by	by	ADP
aiua-13516	5	23	modulating	modulate	VERB
aiua-13516	5	24	the	the	DET
aiua-13516	5	25	extracellular	extracellular	ADJ
aiua-13516	5	26	matrix	matrix	NOUN
aiua-13516	5	27	,	,	PUNCT
aiua-13516	5	28	angiogenesis	angiogenesis	NOUN
aiua-13516	5	29	,	,	PUNCT
aiua-13516	5	30	and	and	CCONJ
aiua-13516	5	31	immune	immune	ADJ
aiua-13516	5	32	evasion	evasion	NOUN
aiua-13516	5	33	(	(	PUNCT
aiua-13516	5	34	9	9	NUM
aiua-13516	5	35	-	-	SYM
aiua-13516	5	36	11	11	NUM
aiua-13516	5	37	)	)	PUNCT
aiua-13516	5	38	.	.	PUNCT
aiua-13516	6	1	lactylation	lactylation	NOUN
aiua-13516	6	2	has	have	AUX
aiua-13516	6	3	also	also	ADV
aiua-13516	6	4	been	be	AUX
aiua-13516	6	5	found	find	VERB
aiua-13516	6	6	to	to	PART
aiua-13516	6	7	alter	alter	VERB
aiua-13516	6	8	the	the	DET
aiua-13516	6	9	activity	activity	NOUN
aiua-13516	6	10	and	and	CCONJ
aiua-13516	6	11	stability	stability	NOUN
aiua-13516	6	12	of	of	ADP
aiua-13516	6	13	intracellular	intracellular	ADJ
aiua-13516	6	14	proteins	protein	NOUN
aiua-13516	6	15	,	,	PUNCT
aiua-13516	6	16	leading	lead	VERB
aiua-13516	6	17	to	to	ADP
aiua-13516	6	18	changes	change	NOUN
aiua-13516	6	19	in	in	ADP
aiua-13516	6	20	certain	certain	ADJ
aiua-13516	6	21	cellular	cellular	ADJ
aiua-13516	6	22	processes	process	NOUN
aiua-13516	6	23	including	include	VERB
aiua-13516	6	24	glycolysis	glycolysis	NOUN
aiua-13516	6	25	(	(	PUNCT
aiua-13516	6	26	12	12	NUM
aiua-13516	6	27	,	,	PUNCT
aiua-13516	6	28	13	13	NUM
aiua-13516	6	29	)	)	PUNCT
aiua-13516	6	30	and	and	CCONJ
aiua-13516	6	31	apoptosis	apoptosis	NOUN
aiua-13516	6	32	(	(	PUNCT
aiua-13516	6	33	14	14	NUM
aiua-13516	6	34	)	)	PUNCT
aiua-13516	6	35	.	.	PUNCT
aiua-13516	7	1	in	in	ADP
aiua-13516	7	2	addition	addition	NOUN
aiua-13516	7	3	,	,	PUNCT
aiua-13516	7	4	lactylation	lactylation	NOUN
aiua-13516	7	5	can	can	AUX
aiua-13516	7	6	further	far	ADV
aiua-13516	7	7	affect	affect	VERB
aiua-13516	7	8	the	the	DET
aiua-13516	7	9	interactions	interaction	NOUN
aiua-13516	7	10	between	between	ADP
aiua-13516	7	11	tumor	tumor	NOUN
aiua-13516	7	12	cells	cell	NOUN
aiua-13516	7	13	and	and	CCONJ
aiua-13516	7	14	their	their	PRON
aiua-13516	7	15	microenvironment	microenvironment	NOUN
aiua-13516	7	16	by	by	ADP
aiua-13516	7	17	promoting	promote	VERB
aiua-13516	7	18	or	or	CCONJ
aiua-13516	7	19	inhibiting	inhibit	VERB
aiua-13516	7	20	tumor	tumor	NOUN
aiua-13516	7	21	progression	progression	NOUN
aiua-13516	7	22	(	(	PUNCT
aiua-13516	7	23	15	15	NUM
aiua-13516	7	24	-	-	SYM
aiua-13516	7	25	17	17	NUM
aiua-13516	7	26	)	)	PUNCT
aiua-13516	7	27	.	.	PUNCT
aiua-13516	8	1	these	these	DET
aiua-13516	8	2	findings	finding	NOUN
aiua-13516	8	3	suggest	suggest	VERB
aiua-13516	8	4	that	that	SCONJ
aiua-13516	8	5	lactylation	lactylation	NOUN
aiua-13516	8	6	may	may	AUX
aiua-13516	8	7	serve	serve	VERB
aiua-13516	8	8	as	as	ADP
aiua-13516	8	9	a	a	DET
aiua-13516	8	10	potential	potential	ADJ
aiua-13516	8	11	target	target	NOUN
aiua-13516	8	12	for	for	ADP
aiua-13516	8	13	the	the	DET
aiua-13516	8	14	development	development	NOUN
aiua-13516	8	15	of	of	ADP
aiua-13516	8	16	novel	novel	ADJ
aiua-13516	8	17	cancer	cancer	NOUN
aiua-13516	8	18	therapeutics	therapeutic	NOUN
aiua-13516	8	19	to	to	PART
aiua-13516	8	20	interfere	interfere	VERB
aiua-13516	8	21	with	with	ADP
aiua-13516	8	22	lactate	lactate	NOUN
aiua-13516	8	23	signaling	signal	VERB
aiua-13516	8	24	pathways	pathway	NOUN
aiua-13516	8	25	and	and	CCONJ
aiua-13516	8	26	disrupt	disrupt	VERB
aiua-13516	8	27	tumor	tumor	NOUN
aiua-13516	8	28	progression	progression	NOUN
aiua-13516	8	29	.	.	PUNCT
aiua-13516	9	1	however	however	ADV
aiua-13516	9	2	,	,	PUNCT
aiua-13516	9	3	the	the	DET
aiua-13516	9	4	role	role	NOUN
aiua-13516	9	5	of	of	ADP
aiua-13516	9	6	lactylation	lactylation	NOUN
aiua-13516	9	7	in	in	ADP
aiua-13516	9	8	blca	blca	PROPN
aiua-13516	9	9	remains	remain	VERB
aiua-13516	9	10	still	still	ADV
aiua-13516	9	11	unclear	unclear	ADJ
aiua-13516	9	12	.	.	PUNCT
aiua-13516	10	1	in	in	ADP
aiua-13516	10	2	this	this	DET
aiua-13516	10	3	present	present	ADJ
aiua-13516	10	4	study	study	NOUN
aiua-13516	10	5	,	,	PUNCT
aiua-13516	10	6	we	we	PRON
aiua-13516	10	7	aimed	aim	VERB
aiua-13516	10	8	to	to	PART
aiua-13516	10	9	identify	identify	VERB
aiua-13516	10	10	lactylationrelated	lactylationrelate	VERB
aiua-13516	10	11	gene	gene	NOUN
aiua-13516	10	12	subtypes	subtype	NOUN
aiua-13516	10	13	of	of	ADP
aiua-13516	10	14	blca	blca	NOUN
aiua-13516	10	15	through	through	ADP
aiua-13516	10	16	unsupervised	unsupervised	ADJ
aiua-13516	10	17	clustering	clustering	NOUN
aiua-13516	10	18	in	in	ADP
aiua-13516	10	19	order	order	NOUN
aiua-13516	10	20	to	to	PART
aiua-13516	10	21	compare	compare	VERB
aiua-13516	10	22	clinical	clinical	ADJ
aiua-13516	10	23	features	feature	NOUN
aiua-13516	10	24	,	,	PUNCT
aiua-13516	10	25	differentially	differentially	ADV
aiua-13516	10	26	expressed	express	VERB
aiua-13516	10	27	genes	gene	NOUN
aiua-13516	10	28	(	(	PUNCT
aiua-13516	10	29	degs	deg	NOUN
aiua-13516	10	30	)	)	PUNCT
aiua-13516	10	31	,	,	PUNCT
aiua-13516	10	32	pathways	pathway	NOUN
aiua-13516	10	33	and	and	CCONJ
aiua-13516	10	34	immune	immune	ADJ
aiua-13516	10	35	cell	cell	NOUN
aiua-13516	10	36	infiltration	infiltration	NOUN
aiua-13516	10	37	between	between	ADP
aiua-13516	10	38	the	the	DET
aiua-13516	10	39	lactylation	lactylation	NOUN
aiua-13516	10	40	-	-	PUNCT
aiua-13516	10	41	related	relate	VERB
aiua-13516	10	42	gene	gene	NOUN
aiua-13516	10	43	subtypes	subtype	NOUN
aiua-13516	10	44	identified	identify	VERB
aiua-13516	10	45	.	.	PUNCT
aiua-13516	11	1	furthermore	furthermore	ADV
aiua-13516	11	2	,	,	PUNCT
aiua-13516	11	3	by	by	ADP
aiua-13516	11	4	establishing	establish	VERB
aiua-13516	11	5	a	a	DET
aiua-13516	11	6	special	special	ADJ
aiua-13516	11	7	lactylation	lactylation	NOUN
aiua-13516	11	8	score	score	NOUN
aiua-13516	11	9	we	we	PRON
aiua-13516	11	10	also	also	ADV
aiua-13516	11	11	aimed	aim	VERB
aiua-13516	11	12	to	to	PART
aiua-13516	11	13	predict	predict	VERB
aiua-13516	11	14	the	the	DET
aiua-13516	11	15	overall	overall	ADJ
aiua-13516	11	16	survival	survival	NOUN
aiua-13516	11	17	of	of	ADP
aiua-13516	11	18	blca	blca	ADJ
aiua-13516	11	19	patients	patient	NOUN
aiua-13516	11	20	.	.	PUNCT
aiua-13516	12	1	lastly	lastly	ADV
aiua-13516	12	2	,	,	PUNCT
aiua-13516	12	3	we	we	PRON
aiua-13516	12	4	investigated	investigate	VERB
aiua-13516	12	5	the	the	DET
aiua-13516	12	6	correlation	correlation	NOUN
aiua-13516	12	7	between	between	ADP
aiua-13516	12	8	the	the	DET
aiua-13516	12	9	lactylation	lactylation	NOUN
aiua-13516	12	10	score	score	NOUN
aiua-13516	12	11	and	and	CCONJ
aiua-13516	12	12	the	the	DET
aiua-13516	12	13	tumor	tumor	NOUN
aiua-13516	12	14	immune	immune	ADJ
aiua-13516	12	15	microenvironment	microenvironment	NOUN
aiua-13516	12	16	,	,	PUNCT
aiua-13516	12	17	as	as	ADV
aiua-13516	12	18	well	well	ADV
aiua-13516	12	19	as	as	ADP
aiua-13516	12	20	the	the	DET
aiua-13516	12	21	potential	potential	NOUN
aiua-13516	12	22	for	for	ADP
aiua-13516	12	23	immunotherapeutic	immunotherapeutic	ADJ
aiua-13516	12	24	efficacy	efficacy	NOUN
aiua-13516	12	25	.	.	PUNCT
aiua-13516	13	1	objective	objective	NOUN
aiua-13516	13	2	:	:	PUNCT
aiua-13516	14	1	lactylation	lactylation	NOUN
aiua-13516	14	2	is	be	AUX
aiua-13516	14	3	a	a	DET
aiua-13516	14	4	type	type	NOUN
aiua-13516	14	5	of	of	ADP
aiua-13516	14	6	chemical	chemical	NOUN
aiua-13516	14	7	modification	modification	NOUN
aiua-13516	14	8	involving	involve	VERB
aiua-13516	14	9	the	the	DET
aiua-13516	14	10	introduction	introduction	NOUN
aiua-13516	14	11	of	of	ADP
aiua-13516	14	12	lactyl	lactyl	NOUN
aiua-13516	14	13	groups	group	NOUN
aiua-13516	14	14	to	to	ADP
aiua-13516	14	15	a	a	DET
aiua-13516	14	16	molecule	molecule	NOUN
aiua-13516	14	17	which	which	PRON
aiua-13516	14	18	can	can	AUX
aiua-13516	14	19	affect	affect	VERB
aiua-13516	14	20	the	the	DET
aiua-13516	14	21	interactions	interaction	NOUN
aiua-13516	14	22	between	between	ADP
aiua-13516	14	23	tumor	tumor	NOUN
aiua-13516	14	24	cells	cell	NOUN
aiua-13516	14	25	and	and	CCONJ
aiua-13516	14	26	their	their	PRON
aiua-13516	14	27	microenvironment	microenvironment	NOUN
aiua-13516	14	28	.	.	PUNCT
aiua-13516	15	1	this	this	DET
aiua-13516	15	2	study	study	NOUN
aiua-13516	15	3	aims	aim	VERB
aiua-13516	15	4	to	to	PART
aiua-13516	15	5	evaluate	evaluate	VERB
aiua-13516	15	6	the	the	DET
aiua-13516	15	7	possible	possible	ADJ
aiua-13516	15	8	role	role	NOUN
aiua-13516	15	9	of	of	ADP
aiua-13516	15	10	lactylation	lactylation	NOUN
aiua-13516	15	11	-	-	PUNCT
aiua-13516	15	12	related	relate	VERB
aiua-13516	15	13	gene	gene	NOUN
aiua-13516	15	14	signature	signature	NOUN
aiua-13516	15	15	in	in	ADP
aiua-13516	15	16	the	the	DET
aiua-13516	15	17	prediction	prediction	NOUN
aiua-13516	15	18	of	of	ADP
aiua-13516	15	19	both	both	CCONJ
aiua-13516	15	20	prognosis	prognosis	NOUN
aiua-13516	15	21	and	and	CCONJ
aiua-13516	15	22	immunotherapy	immunotherapy	NOUN
aiua-13516	15	23	response	response	NOUN
aiua-13516	15	24	in	in	ADP
aiua-13516	15	25	bladder	bladder	NOUN
aiua-13516	15	26	cancer	cancer	NOUN
aiua-13516	15	27	(	(	PUNCT
aiua-13516	15	28	blca	blca	PROPN
aiua-13516	15	29	)	)	PUNCT
aiua-13516	15	30	.	.	PUNCT
aiua-13516	16	1	methods	method	NOUN
aiua-13516	16	2	:	:	PUNCT
aiua-13516	16	3	lactylation	lactylation	NOUN
aiua-13516	16	4	-	-	PUNCT
aiua-13516	16	5	related	relate	VERB
aiua-13516	16	6	genes	gene	NOUN
aiua-13516	16	7	were	be	AUX
aiua-13516	16	8	obtained	obtain	VERB
aiua-13516	16	9	from	from	ADP
aiua-13516	16	10	the	the	DET
aiua-13516	16	11	published	publish	VERB
aiua-13516	16	12	work	work	NOUN
aiua-13516	16	13	and	and	CCONJ
aiua-13516	16	14	two	two	NUM
aiua-13516	16	15	subtypes	subtype	NOUN
aiua-13516	16	16	(	(	PUNCT
aiua-13516	16	17	cluster	cluster	NOUN
aiua-13516	16	18	a	a	PRON
aiua-13516	16	19	and	and	CCONJ
aiua-13516	16	20	b	b	NOUN
aiua-13516	16	21	)	)	PUNCT
aiua-13516	16	22	were	be	AUX
aiua-13516	16	23	identified	identify	VERB
aiua-13516	16	24	through	through	ADP
aiua-13516	16	25	unsupervised	unsupervised	ADJ
aiua-13516	16	26	clustering	clustering	NOUN
aiua-13516	16	27	.	.	PUNCT
aiua-13516	17	1	the	the	DET
aiua-13516	17	2	differences	difference	NOUN
aiua-13516	17	3	including	include	VERB
aiua-13516	17	4	clinical	clinical	ADJ
aiua-13516	17	5	features	feature	NOUN
aiua-13516	17	6	,	,	PUNCT
aiua-13516	17	7	differentially	differentially	ADV
aiua-13516	17	8	expressed	express	VERB
aiua-13516	17	9	genes	gene	NOUN
aiua-13516	17	10	(	(	PUNCT
aiua-13516	17	11	degs	deg	NOUN
aiua-13516	17	12	)	)	PUNCT
aiua-13516	17	13	,	,	PUNCT
aiua-13516	17	14	pathways	pathway	NOUN
aiua-13516	17	15	,	,	PUNCT
aiua-13516	17	16	and	and	CCONJ
aiua-13516	17	17	immune	immune	ADJ
aiua-13516	17	18	cell	cell	NOUN
aiua-13516	17	19	infiltration	infiltration	NOUN
aiua-13516	17	20	between	between	ADP
aiua-13516	17	21	these	these	DET
aiua-13516	17	22	two	two	NUM
aiua-13516	17	23	clusters	cluster	NOUN
aiua-13516	17	24	were	be	AUX
aiua-13516	17	25	thoroughly	thoroughly	ADV
aiua-13516	17	26	examined	examine	VERB
aiua-13516	17	27	.	.	PUNCT
aiua-13516	18	1	results	result	NOUN
aiua-13516	18	2	:	:	PUNCT
aiua-13516	18	3	by	by	ADP
aiua-13516	18	4	utilizing	utilize	VERB
aiua-13516	18	5	the	the	DET
aiua-13516	18	6	degs	deg	NOUN
aiua-13516	18	7	between	between	ADP
aiua-13516	18	8	the	the	DET
aiua-13516	18	9	two	two	NUM
aiua-13516	18	10	clusters	cluster	NOUN
aiua-13516	18	11	,	,	PUNCT
aiua-13516	18	12	a	a	DET
aiua-13516	18	13	lactylation	lactylation	NOUN
aiua-13516	18	14	score	score	NOUN
aiua-13516	18	15	was	be	AUX
aiua-13516	18	16	identified	identify	VERB
aiua-13516	18	17	to	to	PART
aiua-13516	18	18	predict	predict	VERB
aiua-13516	18	19	the	the	DET
aiua-13516	18	20	overall	overall	ADJ
aiua-13516	18	21	survival	survival	NOUN
aiua-13516	18	22	status	status	NOUN
aiua-13516	18	23	and	and	CCONJ
aiua-13516	18	24	the	the	DET
aiua-13516	18	25	response	response	NOUN
aiua-13516	18	26	of	of	ADP
aiua-13516	18	27	blca	blca	ADJ
aiua-13516	18	28	patients	patient	NOUN
aiua-13516	18	29	receiving	receive	VERB
aiua-13516	18	30	immunotherapy	immunotherapy	NOUN
aiua-13516	18	31	.	.	PUNCT
aiua-13516	19	1	our	our	PRON
aiua-13516	19	2	results	result	NOUN
aiua-13516	19	3	demonstrated	demonstrate	VERB
aiua-13516	19	4	that	that	SCONJ
aiua-13516	19	5	patients	patient	NOUN
aiua-13516	19	6	with	with	ADP
aiua-13516	19	7	a	a	DET
aiua-13516	19	8	high	high	ADJ
aiua-13516	19	9	lactylation	lactylation	NOUN
aiua-13516	19	10	score	score	NOUN
aiua-13516	19	11	tended	tend	VERB
aiua-13516	19	12	to	to	PART
aiua-13516	19	13	have	have	VERB
aiua-13516	19	14	a	a	DET
aiua-13516	19	15	worse	bad	ADJ
aiua-13516	19	16	survival	survival	NOUN
aiua-13516	19	17	period	period	NOUN
aiua-13516	19	18	and	and	CCONJ
aiua-13516	19	19	increased	increase	VERB
aiua-13516	19	20	immune	immune	ADJ
aiua-13516	19	21	cell	cell	NOUN
aiua-13516	19	22	infiltration	infiltration	NOUN
aiua-13516	19	23	level	level	NOUN
aiua-13516	19	24	.	.	PUNCT
aiua-13516	20	1	further	further	ADJ
aiua-13516	20	2	analysis	analysis	NOUN
aiua-13516	20	3	showed	show	VERB
aiua-13516	20	4	that	that	SCONJ
aiua-13516	20	5	high	high	ADJ
aiua-13516	20	6	lactylation	lactylation	NOUN
aiua-13516	20	7	score	score	NOUN
aiua-13516	20	8	may	may	AUX
aiua-13516	20	9	be	be	AUX
aiua-13516	20	10	associated	associate	VERB
aiua-13516	20	11	with	with	ADP
aiua-13516	20	12	higher	high	ADJ
aiua-13516	20	13	sensitivity	sensitivity	NOUN
aiua-13516	20	14	to	to	ADP
aiua-13516	20	15	immune	immune	ADJ
aiua-13516	20	16	checkpoint	checkpoint	NOUN
aiua-13516	20	17	inhibitor	inhibitor	NOUN
aiua-13516	20	18	(	(	PUNCT
aiua-13516	20	19	ici	ici	PROPN
aiua-13516	20	20	)	)	PUNCT
aiua-13516	20	21	treatment	treatment	NOUN
aiua-13516	20	22	which	which	PRON
aiua-13516	20	23	is	be	AUX
aiua-13516	20	24	crucial	crucial	ADJ
aiua-13516	20	25	in	in	ADP
aiua-13516	20	26	the	the	DET
aiua-13516	20	27	identification	identification	NOUN
aiua-13516	20	28	of	of	ADP
aiua-13516	20	29	the	the	DET
aiua-13516	20	30	suitable	suitable	ADJ
aiua-13516	20	31	candidates	candidate	NOUN
aiua-13516	20	32	for	for	ADP
aiua-13516	20	33	ici	ici	NOUN
aiua-13516	20	34	therapy	therapy	NOUN
aiua-13516	20	35	.	.	PUNCT
aiua-13516	21	1	conclusions	conclusion	NOUN
aiua-13516	21	2	:	:	PUNCT
aiua-13516	21	3	our	our	PRON
aiua-13516	21	4	results	result	NOUN
aiua-13516	21	5	emphasize	emphasize	VERB
aiua-13516	21	6	the	the	DET
aiua-13516	21	7	possible	possible	ADJ
aiua-13516	21	8	predictive	predictive	ADJ
aiua-13516	21	9	role	role	NOUN
aiua-13516	21	10	of	of	ADP
aiua-13516	21	11	lactylation	lactylation	NOUN
aiua-13516	21	12	-	-	PUNCT
aiua-13516	21	13	related	relate	VERB
aiua-13516	21	14	gene	gene	NOUN
aiua-13516	21	15	signature	signature	NOUN
aiua-13516	21	16	both	both	CCONJ
aiua-13516	21	17	in	in	ADP
aiua-13516	21	18	the	the	DET
aiua-13516	21	19	survival	survival	NOUN
aiua-13516	21	20	rates	rate	NOUN
aiua-13516	21	21	of	of	ADP
aiua-13516	21	22	blca	blca	PROPN
aiua-13516	21	23	and	and	CCONJ
aiua-13516	21	24	its	its	PRON
aiua-13516	21	25	implications	implication	NOUN
aiua-13516	21	26	for	for	ADP
aiua-13516	21	27	treatment	treatment	NOUN
aiua-13516	21	28	strategies	strategy	NOUN
aiua-13516	21	29	.	.	PUNCT
aiua-13516	22	1	key	key	ADJ
aiua-13516	22	2	words	word	NOUN
aiua-13516	22	3	:	:	PUNCT
aiua-13516	22	4	lactylation	lactylation	NOUN
aiua-13516	22	5	;	;	PUNCT
aiua-13516	22	6	gene	gene	NOUN
aiua-13516	22	7	signature	signature	NOUN
aiua-13516	22	8	;	;	PUNCT
aiua-13516	22	9	bladder	bladder	NOUN
aiua-13516	22	10	cancer	cancer	NOUN
aiua-13516	22	11	;	;	PUNCT
aiua-13516	22	12	prognosis	prognosis	NOUN
aiua-13516	22	13	;	;	PUNCT
aiua-13516	22	14	immunotherapy	immunotherapy	NOUN
aiua-13516	22	15	.	.	PUNCT
aiua-13516	22	16	submitted	submit	VERB
aiua-13516	22	17	22	22	NUM
aiua-13516	22	18	december	december	PROPN
aiua-13516	22	19	2024	2024	NUM
aiua-13516	22	20	;	;	PUNCT
aiua-13516	22	21	accepted	accept	VERB
aiua-13516	22	22	3	3	NUM
aiua-13516	22	23	january	january	PROPN
aiua-13516	22	24	2025	2025	NUM
aiua-13516	22	25	introduction	introduction	NOUN
aiua-13516	22	26	bladder	bladder	NOUN
aiua-13516	22	27	cancer	cancer	NOUN
aiua-13516	22	28	(	(	PUNCT
aiua-13516	22	29	blca	blca	PROPN
aiua-13516	22	30	)	)	PUNCT
aiua-13516	22	31	is	be	AUX
aiua-13516	22	32	one	one	NUM
aiua-13516	22	33	of	of	ADP
aiua-13516	22	34	the	the	DET
aiua-13516	22	35	most	most	ADV
aiua-13516	22	36	common	common	ADJ
aiua-13516	22	37	malignant	malignant	ADJ
aiua-13516	22	38	pathologies	pathology	NOUN
aiua-13516	22	39	of	of	ADP
aiua-13516	22	40	the	the	DET
aiua-13516	22	41	genitourinary	genitourinary	ADJ
aiua-13516	22	42	tract	tract	NOUN
aiua-13516	22	43	,	,	PUNCT
aiua-13516	22	44	with	with	ADP
aiua-13516	22	45	approximately	approximately	ADV
aiua-13516	22	46	573,000	573,000	NUM
aiua-13516	22	47	new	new	ADJ
aiua-13516	22	48	cases	case	NOUN
aiua-13516	22	49	and	and	CCONJ
aiua-13516	22	50	212,000	212,000	NUM
aiua-13516	22	51	deaths	death	NOUN
aiua-13516	22	52	per	per	ADP
aiua-13516	22	53	year	year	NOUN
aiua-13516	22	54	worldwide	worldwide	ADV
aiua-13516	22	55	.	.	PUNCT
aiua-13516	23	1	the	the	DET
aiua-13516	23	2	incidence	incidence	NOUN
aiua-13516	23	3	of	of	ADP
aiua-13516	23	4	blca	blca	NOUN
aiua-13516	23	5	is	be	AUX
aiua-13516	23	6	still	still	ADV
aiua-13516	23	7	increasing	increase	VERB
aiua-13516	23	8	owing	owe	VERB
aiua-13516	23	9	to	to	ADP
aiua-13516	23	10	population	population	NOUN
aiua-13516	23	11	growth	growth	NOUN
aiua-13516	23	12	and	and	CCONJ
aiua-13516	23	13	ageing	age	VERB
aiua-13516	23	14	(	(	PUNCT
aiua-13516	23	15	1	1	NUM
aiua-13516	23	16	-	-	SYM
aiua-13516	23	17	3	3	NUM
aiua-13516	23	18	)	)	PUNCT
aiua-13516	23	19	.	.	PUNCT
aiua-13516	24	1	in	in	ADP
aiua-13516	24	2	recent	recent	ADJ
aiua-13516	24	3	years	year	NOUN
aiua-13516	24	4	,	,	PUNCT
aiua-13516	24	5	immune	immune	ADJ
aiua-13516	24	6	checkpoint	checkpoint	NOUN
aiua-13516	24	7	inhibitors	inhibitor	NOUN
aiua-13516	24	8	(	(	PUNCT
aiua-13516	24	9	icis	icis	NOUN
aiua-13516	24	10	)	)	PUNCT
aiua-13516	24	11	took	take	VERB
aiua-13516	24	12	attention	attention	NOUN
aiua-13516	24	13	as	as	ADP
aiua-13516	24	14	predictive	predictive	ADJ
aiua-13516	24	15	role	role	NOUN
aiua-13516	24	16	of	of	ADP
aiua-13516	24	17	lactylation	lactylation	NOUN
aiua-13516	24	18	-	-	PUNCT
aiua-13516	24	19	related	relate	VERB
aiua-13516	24	20	gene	gene	NOUN
aiua-13516	24	21	signature	signature	NOUN
aiua-13516	24	22	in	in	ADP
aiua-13516	24	23	the	the	DET
aiua-13516	24	24	prognosis	prognosis	NOUN
aiua-13516	24	25	and	and	CCONJ
aiua-13516	24	26	immunotherapy	immunotherapy	NOUN
aiua-13516	24	27	response	response	NOUN
aiua-13516	24	28	in	in	ADP
aiua-13516	24	29	bladder	bladder	NOUN
aiua-13516	24	30	cancer	cancer	NOUN
aiua-13516	24	31	guoyuan	guoyuan	PROPN
aiua-13516	24	32	liu	liu	PROPN
aiua-13516	24	33	1	1	PROPN
aiua-13516	24	34	*	*	PROPN
aiua-13516	24	35	,	,	PUNCT
aiua-13516	24	36	ting	te	VERB
aiua-13516	24	37	hong	hong	PROPN
aiua-13516	24	38	2	2	NUM
aiua-13516	24	39	*	*	PROPN
aiua-13516	24	40	,	,	PUNCT
aiua-13516	24	41	xinyu	xinyu	PROPN
aiua-13516	24	42	liu	liu	PROPN
aiua-13516	24	43	2	2	PROPN
aiua-13516	24	44	*	*	PROPN
aiua-13516	24	45	,	,	PUNCT
aiua-13516	24	46	xuanhao	xuanhao	PROPN
aiua-13516	24	47	lin	lin	PROPN
aiua-13516	24	48	3	3	NUM
aiua-13516	24	49	,	,	PUNCT
aiua-13516	24	50	peixiu	peixiu	NOUN
aiua-13516	24	51	yao	yao	PROPN
aiua-13516	24	52	3	3	NUM
aiua-13516	24	53	,	,	PUNCT
aiua-13516	24	54	xifeng	xifeng	PROPN
aiua-13516	24	55	chen	chen	PROPN
aiua-13516	24	56	3	3	NUM
aiua-13516	24	57	,	,	PUNCT
aiua-13516	24	58	yonghai	yonghai	PROPN
aiua-13516	24	59	zhang	zhang	PROPN
aiua-13516	24	60	1	1	NUM
aiua-13516	24	61	,	,	PUNCT
aiua-13516	24	62	kemal	kemal	NOUN
aiua-13516	24	63	sarica	sarica	NOUN
aiua-13516	24	64	4	4	NUM
aiua-13516	24	65	,	,	PUNCT
aiua-13516	24	66	5	5	NUM
aiua-13516	24	67	,	,	PUNCT
aiua-13516	24	68	xuwei	xuwei	PROPN
aiua-13516	24	69	hong	hong	PROPN
aiua-13516	24	70	1	1	NUM
aiua-13516	24	71	1	1	NUM
aiua-13516	24	72	department	department	NOUN
aiua-13516	24	73	of	of	ADP
aiua-13516	24	74	urology	urology	NOUN
aiua-13516	24	75	,	,	PUNCT
aiua-13516	24	76	shantou	shantou	PROPN
aiua-13516	24	77	central	central	PROPN
aiua-13516	24	78	hospital	hospital	PROPN
aiua-13516	24	79	,	,	PUNCT
aiua-13516	24	80	shantou	shantou	PROPN
aiua-13516	24	81	,	,	PUNCT
aiua-13516	24	82	china	china	PROPN
aiua-13516	24	83	;	;	PUNCT
aiua-13516	24	84	2	2	NUM
aiua-13516	24	85	clinical	clinical	ADJ
aiua-13516	24	86	medical	medical	ADJ
aiua-13516	24	87	research	research	NOUN
aiua-13516	24	88	center	center	NOUN
aiua-13516	24	89	,	,	PUNCT
aiua-13516	24	90	shantou	shantou	PROPN
aiua-13516	24	91	central	central	PROPN
aiua-13516	24	92	hospital	hospital	PROPN
aiua-13516	24	93	,	,	PUNCT
aiua-13516	24	94	shantou	shantou	PROPN
aiua-13516	24	95	,	,	PUNCT
aiua-13516	24	96	china	china	PROPN
aiua-13516	24	97	;	;	PUNCT
aiua-13516	24	98	3	3	NUM
aiua-13516	24	99	department	department	NOUN
aiua-13516	24	100	of	of	ADP
aiua-13516	24	101	biobank	biobank	PROPN
aiua-13516	24	102	,	,	PUNCT
aiua-13516	24	103	shantou	shantou	PROPN
aiua-13516	24	104	central	central	PROPN
aiua-13516	24	105	hospital	hospital	PROPN
aiua-13516	24	106	,	,	PUNCT
aiua-13516	24	107	shantou	shantou	PROPN
aiua-13516	24	108	,	,	PUNCT
aiua-13516	24	109	china	china	PROPN
aiua-13516	24	110	;	;	PUNCT
aiua-13516	24	111	4	4	NUM
aiua-13516	24	112	department	department	NOUN
aiua-13516	24	113	of	of	ADP
aiua-13516	24	114	urology	urology	NOUN
aiua-13516	24	115	,	,	PUNCT
aiua-13516	24	116	health	health	PROPN
aiua-13516	24	117	sciences	sciences	PROPN
aiua-13516	24	118	university	university	PROPN
aiua-13516	24	119	,	,	PUNCT
aiua-13516	24	120	prof	prof	PROPN
aiua-13516	24	121	.	.	PUNCT
aiua-13516	25	1	dr	dr	PROPN
aiua-13516	25	2	.	.	PROPN
aiua-13516	25	3	ilhan	ilhan	PROPN
aiua-13516	25	4	varank	varank	PROPN
aiua-13516	25	5	education	education	NOUN
aiua-13516	25	6	and	and	CCONJ
aiua-13516	25	7	training	training	NOUN
aiua-13516	25	8	hospital	hospital	NOUN
aiua-13516	25	9	,	,	PUNCT
aiua-13516	25	10	istanbul	istanbul	PROPN
aiua-13516	25	11	,	,	PUNCT
aiua-13516	25	12	turkey	turkey	PROPN
aiua-13516	25	13	;	;	PUNCT
aiua-13516	25	14	5	5	NUM
aiua-13516	25	15	department	department	NOUN
aiua-13516	25	16	of	of	ADP
aiua-13516	25	17	urology	urology	NOUN
aiua-13516	25	18	,	,	PUNCT
aiua-13516	25	19	biruni	biruni	PROPN
aiua-13516	25	20	university	university	NOUN
aiua-13516	25	21	,	,	PUNCT
aiua-13516	25	22	medical	medical	ADJ
aiua-13516	25	23	school	school	NOUN
aiua-13516	25	24	,	,	PUNCT
aiua-13516	25	25	istanbul	istanbul	PROPN
aiua-13516	25	26	,	,	PUNCT
aiua-13516	25	27	turkey	turkey	PROPN
aiua-13516	25	28	.	.	PUNCT
aiua-13516	26	1	*	*	PUNCT
aiua-13516	26	2	these	these	DET
aiua-13516	26	3	authors	author	NOUN
aiua-13516	26	4	contributed	contribute	VERB
aiua-13516	26	5	equally	equally	ADV
aiua-13516	26	6	to	to	ADP
aiua-13516	26	7	this	this	DET
aiua-13516	26	8	work	work	NOUN
aiua-13516	26	9	.	.	PUNCT
aiua-13516	27	1	doi	doi	NOUN
aiua-13516	27	2	:	:	PUNCT
aiua-13516	27	3	10.4081	10.4081	NUM
aiua-13516	27	4	/	/	SYM
aiua-13516	27	5	aiua.2025.13516	aiua.2025.13516	NUM
aiua-13516	27	6	summary	summary	NOUN
aiua-13516	27	7	archivio	archivio	NOUN
aiua-13516	27	8	italiano	italiano	X
aiua-13516	27	9	di	di	X
aiua-13516	27	10	urologia	urologia	PROPN
aiua-13516	27	11	e	e	PROPN
aiua-13516	27	12	andrologia	andrologia	NOUN
aiua-13516	27	13	2025	2025	NUM
aiua-13516	27	14	;	;	PUNCT
aiua-13516	27	15	97(1):13516	97(1):13516	NUM
aiua-13516	27	16	g.	g.	PROPN
aiua-13516	27	17	liu	liu	PROPN
aiua-13516	27	18	,	,	PUNCT
aiua-13516	27	19	t.	t.	PROPN
aiua-13516	27	20	hong	hong	PROPN
aiua-13516	27	21	,	,	PUNCT
aiua-13516	27	22	x.	x.	PROPN
aiua-13516	27	23	liu	liu	PROPN
aiua-13516	27	24	,	,	PUNCT
aiua-13516	27	25	et	et	PROPN
aiua-13516	27	26	al	al	PROPN
aiua-13516	27	27	.	.	PROPN
aiua-13516	27	28	2	2	NUM
aiua-13516	27	29	materials	material	NOUN
aiua-13516	27	30	and	and	CCONJ
aiua-13516	27	31	methods	method	NOUN
aiua-13516	27	32	sources	source	NOUN
aiua-13516	27	33	of	of	ADP
aiua-13516	27	34	sample	sample	NOUN
aiua-13516	27	35	the	the	DET
aiua-13516	27	36	cancer	cancer	NOUN
aiua-13516	27	37	genome	genome	NOUN
aiua-13516	27	38	atlas	atlas	PROPN
aiua-13516	27	39	urothelial	urothelial	ADJ
aiua-13516	27	40	bladder	bladder	NOUN
aiua-13516	27	41	carcinoma	carcinoma	NOUN
aiua-13516	27	42	(	(	PUNCT
aiua-13516	27	43	tcga	tcga	NOUN
aiua-13516	27	44	-	-	PUNCT
aiua-13516	27	45	blca	blca	NOUN
aiua-13516	27	46	)	)	PUNCT
aiua-13516	27	47	is	be	AUX
aiua-13516	27	48	a	a	DET
aiua-13516	27	49	data	data	NOUN
aiua-13516	27	50	collection	collection	NOUN
aiua-13516	27	51	initiative	initiative	NOUN
aiua-13516	27	52	that	that	PRON
aiua-13516	27	53	is	be	AUX
aiua-13516	27	54	part	part	NOUN
aiua-13516	27	55	of	of	ADP
aiua-13516	27	56	a	a	DET
aiua-13516	27	57	larger	large	ADJ
aiua-13516	27	58	effort	effort	NOUN
aiua-13516	27	59	to	to	PART
aiua-13516	27	60	connect	connect	VERB
aiua-13516	27	61	cancer	cancer	NOUN
aiua-13516	27	62	phenotypes	phenotype	NOUN
aiua-13516	27	63	to	to	ADP
aiua-13516	27	64	genotypes	genotype	NOUN
aiua-13516	27	65	.	.	PUNCT
aiua-13516	28	1	the	the	DET
aiua-13516	28	2	data	datum	NOUN
aiua-13516	28	3	includes	include	VERB
aiua-13516	28	4	clinical	clinical	ADJ
aiua-13516	28	5	,	,	PUNCT
aiua-13516	28	6	genetic	genetic	ADJ
aiua-13516	28	7	,	,	PUNCT
aiua-13516	28	8	pathological	pathological	ADJ
aiua-13516	28	9	,	,	PUNCT
aiua-13516	28	10	and	and	CCONJ
aiua-13516	28	11	radiological	radiological	ADJ
aiua-13516	28	12	information	information	NOUN
aiua-13516	28	13	of	of	ADP
aiua-13516	28	14	412	412	NUM
aiua-13516	28	15	tumor	tumor	NOUN
aiua-13516	28	16	samples	sample	NOUN
aiua-13516	28	17	and	and	CCONJ
aiua-13516	28	18	19	19	NUM
aiua-13516	28	19	normal	normal	ADJ
aiua-13516	28	20	samples	sample	NOUN
aiua-13516	28	21	.	.	PUNCT
aiua-13516	29	1	gse13507	gse13507	PROPN
aiua-13516	29	2	is	be	AUX
aiua-13516	29	3	a	a	DET
aiua-13516	29	4	public	public	ADJ
aiua-13516	29	5	gene	gene	NOUN
aiua-13516	29	6	expression	expression	NOUN
aiua-13516	29	7	dataset	dataset	NOUN
aiua-13516	29	8	that	that	PRON
aiua-13516	29	9	identifies	identify	VERB
aiua-13516	29	10	prognosis	prognosis	NOUN
aiua-13516	29	11	-	-	PUNCT
aiua-13516	29	12	related	relate	VERB
aiua-13516	29	13	gene	gene	NOUN
aiua-13516	29	14	signatures	signature	NOUN
aiua-13516	29	15	in	in	ADP
aiua-13516	29	16	blca	blca	PROPN
aiua-13516	29	17	.	.	PUNCT
aiua-13516	30	1	it	it	PRON
aiua-13516	30	2	contains	contain	VERB
aiua-13516	30	3	165	165	NUM
aiua-13516	30	4	primary	primary	ADJ
aiua-13516	30	5	tumors	tumor	NOUN
aiua-13516	30	6	,	,	PUNCT
aiua-13516	30	7	23	23	NUM
aiua-13516	30	8	recurrent	recurrent	ADJ
aiua-13516	30	9	tumors	tumor	NOUN
aiua-13516	30	10	,	,	PUNCT
aiua-13516	30	11	58	58	NUM
aiua-13516	30	12	normal	normal	ADJ
aiua-13516	30	13	bladder	bladder	NOUN
aiua-13516	30	14	mucosae	mucosa	NOUN
aiua-13516	30	15	surrounding	surround	VERB
aiua-13516	30	16	cancer	cancer	NOUN
aiua-13516	30	17	and	and	CCONJ
aiua-13516	30	18	10	10	NUM
aiua-13516	30	19	normal	normal	ADJ
aiua-13516	30	20	bladder	bladder	NOUN
aiua-13516	30	21	mucosae	mucosa	NOUN
aiua-13516	30	22	,	,	PUNCT
aiua-13516	30	23	the	the	DET
aiua-13516	30	24	clinical	clinical	ADJ
aiua-13516	30	25	characteristics	characteristic	NOUN
aiua-13516	30	26	of	of	ADP
aiua-13516	30	27	included	include	VERB
aiua-13516	30	28	samples	sample	NOUN
aiua-13516	30	29	are	be	AUX
aiua-13516	30	30	attached	attach	VERB
aiua-13516	30	31	as	as	ADV
aiua-13516	30	32	well	well	ADV
aiua-13516	30	33	.	.	PUNCT
aiua-13516	31	1	data	datum	NOUN
aiua-13516	31	2	collection	collection	NOUN
aiua-13516	31	3	the	the	DET
aiua-13516	31	4	mrna	mrna	PROPN
aiua-13516	31	5	expression	expression	NOUN
aiua-13516	31	6	profile	profile	NOUN
aiua-13516	31	7	and	and	CCONJ
aiua-13516	31	8	clinical	clinical	ADJ
aiua-13516	31	9	data	datum	NOUN
aiua-13516	31	10	for	for	ADP
aiua-13516	31	11	tcgablca	tcgablca	PROPN
aiua-13516	31	12	(	(	PUNCT
aiua-13516	31	13	412	412	NUM
aiua-13516	31	14	tumor	tumor	NOUN
aiua-13516	31	15	tissues	tissue	NOUN
aiua-13516	31	16	)	)	PUNCT
aiua-13516	31	17	were	be	AUX
aiua-13516	31	18	downloaded	download	VERB
aiua-13516	31	19	from	from	ADP
aiua-13516	31	20	the	the	DET
aiua-13516	31	21	university	university	PROPN
aiua-13516	31	22	of	of	ADP
aiua-13516	31	23	california	california	PROPN
aiua-13516	31	24	santa	santa	PROPN
aiua-13516	31	25	cruz	cruz	PROPN
aiua-13516	31	26	(	(	PUNCT
aiua-13516	31	27	ucsc)-xena	ucsc)-xena	PROPN
aiua-13516	31	28	database	database	NOUN
aiua-13516	31	29	(	(	PUNCT
aiua-13516	31	30	https://xenabrowser.net/datapages/	https://xenabrowser.net/datapages/	NOUN
aiua-13516	31	31	)	)	PUNCT
aiua-13516	31	32	,	,	PUNCT
aiua-13516	31	33	while	while	SCONJ
aiua-13516	31	34	gse13507	gse13507	NOUN
aiua-13516	31	35	(	(	PUNCT
aiua-13516	31	36	165	165	NUM
aiua-13516	31	37	tumor	tumor	NOUN
aiua-13516	31	38	tissues	tissue	NOUN
aiua-13516	31	39	)	)	PUNCT
aiua-13516	31	40	was	be	AUX
aiua-13516	31	41	obtained	obtain	VERB
aiua-13516	31	42	from	from	ADP
aiua-13516	31	43	the	the	DET
aiua-13516	31	44	gene	gene	NOUN
aiua-13516	31	45	expression	expression	NOUN
aiua-13516	31	46	omnibus	omnibus	NOUN
aiua-13516	31	47	(	(	PUNCT
aiua-13516	31	48	geo	geo	PROPN
aiua-13516	31	49	)	)	PUNCT
aiua-13516	31	50	database	database	NOUN
aiua-13516	31	51	(	(	PUNCT
aiua-13516	31	52	https://www.ncbi.nlm.nih.gov/	https://www.ncbi.nlm.nih.gov/	ADV
aiua-13516	31	53	geo/	geo/	PROPN
aiua-13516	31	54	)	)	PUNCT
aiua-13516	31	55	.	.	PUNCT
aiua-13516	32	1	the	the	DET
aiua-13516	32	2	clinical	clinical	ADJ
aiua-13516	32	3	characteristics	characteristic	NOUN
aiua-13516	32	4	and	and	CCONJ
aiua-13516	32	5	survival	survival	NOUN
aiua-13516	32	6	outcomes	outcome	NOUN
aiua-13516	32	7	of	of	ADP
aiua-13516	32	8	blca	blca	ADJ
aiua-13516	32	9	patients	patient	NOUN
aiua-13516	32	10	from	from	ADP
aiua-13516	32	11	these	these	DET
aiua-13516	32	12	two	two	NUM
aiua-13516	32	13	datasets	dataset	NOUN
aiua-13516	32	14	were	be	AUX
aiua-13516	32	15	shown	show	VERB
aiua-13516	32	16	in	in	ADP
aiua-13516	32	17	supplementary	supplementary	ADJ
aiua-13516	32	18	table	table	NOUN
aiua-13516	32	19	s1	s1	NOUN
aiua-13516	32	20	.	.	PUNCT
aiua-13516	33	1	r	r	NOUN
aiua-13516	33	2	package	package	NOUN
aiua-13516	33	3	“	"	PUNCT
aiua-13516	33	4	limma	limma	NOUN
aiua-13516	33	5	”	"	PUNCT
aiua-13516	33	6	was	be	AUX
aiua-13516	33	7	executed	execute	VERB
aiua-13516	33	8	to	to	PART
aiua-13516	33	9	normalize	normalize	VERB
aiua-13516	33	10	the	the	DET
aiua-13516	33	11	expression	expression	NOUN
aiua-13516	33	12	data	datum	NOUN
aiua-13516	33	13	for	for	ADP
aiua-13516	33	14	nonuniform	nonuniform	ADJ
aiua-13516	33	15	matrix	matrix	NOUN
aiua-13516	33	16	distribution	distribution	NOUN
aiua-13516	33	17	.	.	PUNCT
aiua-13516	34	1	to	to	PART
aiua-13516	34	2	improve	improve	VERB
aiua-13516	34	3	the	the	DET
aiua-13516	34	4	reliability	reliability	NOUN
aiua-13516	34	5	,	,	PUNCT
aiua-13516	34	6	the	the	DET
aiua-13516	34	7	two	two	NUM
aiua-13516	34	8	datasets	dataset	NOUN
aiua-13516	34	9	were	be	AUX
aiua-13516	34	10	merged	merge	VERB
aiua-13516	34	11	and	and	CCONJ
aiua-13516	34	12	batch	batch	NOUN
aiua-13516	34	13	effects	effect	NOUN
aiua-13516	34	14	were	be	AUX
aiua-13516	34	15	removed	remove	VERB
aiua-13516	34	16	using	use	VERB
aiua-13516	34	17	the	the	DET
aiua-13516	34	18	r	r	NOUN
aiua-13516	34	19	package	package	NOUN
aiua-13516	34	20	“	"	PUNCT
aiua-13516	34	21	sva	sva	X
aiua-13516	34	22	”	"	PUNCT
aiua-13516	34	23	.	.	PUNCT
aiua-13516	35	1	the	the	DET
aiua-13516	35	2	gene	gene	NOUN
aiua-13516	35	3	set	set	VERB
aiua-13516	35	4	for	for	ADP
aiua-13516	35	5	lactylation	lactylation	NOUN
aiua-13516	35	6	was	be	AUX
aiua-13516	35	7	acquired	acquire	VERB
aiua-13516	35	8	from	from	ADP
aiua-13516	35	9	the	the	DET
aiua-13516	35	10	published	publish	VERB
aiua-13516	35	11	work	work	NOUN
aiua-13516	35	12	(	(	PUNCT
aiua-13516	35	13	18	18	NUM
aiua-13516	35	14	)	)	PUNCT
aiua-13516	35	15	.	.	PUNCT
aiua-13516	36	1	online	online	ADJ
aiua-13516	36	2	analysis	analysis	NOUN
aiua-13516	36	3	the	the	DET
aiua-13516	36	4	genetic	genetic	ADJ
aiua-13516	36	5	alteration	alteration	NOUN
aiua-13516	36	6	of	of	ADP
aiua-13516	36	7	selected	select	VERB
aiua-13516	36	8	genes	gene	NOUN
aiua-13516	36	9	,	,	PUNCT
aiua-13516	36	10	including	include	VERB
aiua-13516	36	11	copy	copy	NOUN
aiua-13516	36	12	number	number	NOUN
aiua-13516	36	13	variant	variant	NOUN
aiua-13516	36	14	(	(	PUNCT
aiua-13516	36	15	cnv	cnv	NOUN
aiua-13516	36	16	)	)	PUNCT
aiua-13516	36	17	,	,	PUNCT
aiua-13516	36	18	methylation	methylation	NOUN
aiua-13516	36	19	and	and	CCONJ
aiua-13516	36	20	mutation	mutation	NOUN
aiua-13516	36	21	,	,	PUNCT
aiua-13516	36	22	were	be	AUX
aiua-13516	36	23	conducted	conduct	VERB
aiua-13516	36	24	using	use	VERB
aiua-13516	36	25	gene	gene	NOUN
aiua-13516	36	26	set	set	VERB
aiua-13516	36	27	cancer	cancer	NOUN
aiua-13516	36	28	analysis	analysis	NOUN
aiua-13516	36	29	(	(	PUNCT
aiua-13516	36	30	gsca	gsca	NOUN
aiua-13516	36	31	)	)	PUNCT
aiua-13516	36	32	database	database	NOUN
aiua-13516	36	33	(	(	PUNCT
aiua-13516	36	34	http://bioinfo.life.hust.edu.cn/gsca/#/	http://bioinfo.life.hust.edu.cn/gsca/#/	PROPN
aiua-13516	36	35	)	)	PUNCT
aiua-13516	36	36	,	,	PUNCT
aiua-13516	36	37	which	which	PRON
aiua-13516	36	38	is	be	AUX
aiua-13516	36	39	an	an	DET
aiua-13516	36	40	integrated	integrate	VERB
aiua-13516	36	41	platform	platform	NOUN
aiua-13516	36	42	for	for	ADP
aiua-13516	36	43	genomic	genomic	NOUN
aiua-13516	36	44	,	,	PUNCT
aiua-13516	36	45	pharmacogenomic	pharmacogenomic	ADJ
aiua-13516	36	46	,	,	PUNCT
aiua-13516	36	47	and	and	CCONJ
aiua-13516	36	48	immunogenomic	immunogenomic	ADJ
aiua-13516	36	49	gene	gene	NOUN
aiua-13516	36	50	set	set	VERB
aiua-13516	36	51	cancer	cancer	NOUN
aiua-13516	36	52	analysis	analysis	NOUN
aiua-13516	36	53	.	.	PUNCT
aiua-13516	37	1	the	the	DET
aiua-13516	37	2	platform	platform	NOUN
aiua-13516	37	3	has	have	VERB
aiua-13516	37	4	four	four	NUM
aiua-13516	37	5	main	main	ADJ
aiua-13516	37	6	functional	functional	ADJ
aiua-13516	37	7	modules	module	NOUN
aiua-13516	37	8	for	for	ADP
aiua-13516	37	9	cancer	cancer	NOUN
aiua-13516	37	10	gsa	gsa	PROPN
aiua-13516	37	11	to	to	PART
aiua-13516	37	12	explore	explore	VERB
aiua-13516	37	13	,	,	PUNCT
aiua-13516	37	14	analyze	analyze	VERB
aiua-13516	37	15	and	and	CCONJ
aiua-13516	37	16	visualize	visualize	VERB
aiua-13516	37	17	expression	expression	NOUN
aiua-13516	37	18	,	,	PUNCT
aiua-13516	37	19	genomic	genomic	ADJ
aiua-13516	37	20	variations	variation	NOUN
aiua-13516	37	21	,	,	PUNCT
aiua-13516	37	22	tumor	tumor	NOUN
aiua-13516	37	23	immune	immune	ADJ
aiua-13516	37	24	infiltration	infiltration	NOUN
aiua-13516	37	25	,	,	PUNCT
aiua-13516	37	26	drug	drug	NOUN
aiua-13516	37	27	sensitivity	sensitivity	NOUN
aiua-13516	37	28	and	and	CCONJ
aiua-13516	37	29	their	their	PRON
aiua-13516	37	30	associations	association	NOUN
aiua-13516	37	31	with	with	ADP
aiua-13516	37	32	clinical	clinical	ADJ
aiua-13516	37	33	outcomes	outcome	NOUN
aiua-13516	37	34	.	.	PUNCT
aiua-13516	38	1	enrichment	enrichment	NOUN
aiua-13516	38	2	analysis	analysis	NOUN
aiua-13516	38	3	gene	gene	NOUN
aiua-13516	38	4	ontology	ontology	NOUN
aiua-13516	38	5	(	(	PUNCT
aiua-13516	38	6	go	go	VERB
aiua-13516	38	7	)	)	PUNCT
aiua-13516	38	8	analysis	analysis	NOUN
aiua-13516	38	9	and	and	CCONJ
aiua-13516	38	10	kyoto	kyoto	NOUN
aiua-13516	38	11	encyclopedia	encyclopedia	NOUN
aiua-13516	38	12	of	of	ADP
aiua-13516	38	13	genes	gene	NOUN
aiua-13516	38	14	and	and	CCONJ
aiua-13516	38	15	genomes	genome	NOUN
aiua-13516	38	16	(	(	PUNCT
aiua-13516	38	17	kegg	kegg	NOUN
aiua-13516	38	18	)	)	PUNCT
aiua-13516	38	19	analysis	analysis	NOUN
aiua-13516	38	20	are	be	AUX
aiua-13516	38	21	two	two	NUM
aiua-13516	38	22	common	common	ADJ
aiua-13516	38	23	functional	functional	ADJ
aiua-13516	38	24	annotation	annotation	NOUN
aiua-13516	38	25	methods	method	NOUN
aiua-13516	38	26	,	,	PUNCT
aiua-13516	38	27	which	which	PRON
aiua-13516	38	28	are	be	AUX
aiua-13516	38	29	mainly	mainly	ADV
aiua-13516	38	30	used	use	VERB
aiua-13516	38	31	to	to	PART
aiua-13516	38	32	study	study	VERB
aiua-13516	38	33	the	the	DET
aiua-13516	38	34	functions	function	NOUN
aiua-13516	38	35	of	of	ADP
aiua-13516	38	36	genes	gene	NOUN
aiua-13516	38	37	and	and	CCONJ
aiua-13516	38	38	proteins	protein	NOUN
aiua-13516	38	39	.	.	PUNCT
aiua-13516	39	1	go	go	VERB
aiua-13516	39	2	analysis	analysis	NOUN
aiua-13516	39	3	is	be	AUX
aiua-13516	39	4	performed	perform	VERB
aiua-13516	39	5	by	by	ADP
aiua-13516	39	6	classifying	classify	VERB
aiua-13516	39	7	the	the	DET
aiua-13516	39	8	function	function	NOUN
aiua-13516	39	9	of	of	ADP
aiua-13516	39	10	a	a	DET
aiua-13516	39	11	gene	gene	NOUN
aiua-13516	39	12	or	or	CCONJ
aiua-13516	39	13	protein	protein	NOUN
aiua-13516	39	14	into	into	ADP
aiua-13516	39	15	three	three	NUM
aiua-13516	39	16	distinct	distinct	ADJ
aiua-13516	39	17	levels	level	NOUN
aiua-13516	39	18	:	:	PUNCT
aiua-13516	39	19	molecular	molecular	ADJ
aiua-13516	39	20	function	function	NOUN
aiua-13516	39	21	,	,	PUNCT
aiua-13516	39	22	cellular	cellular	ADJ
aiua-13516	39	23	component	component	NOUN
aiua-13516	39	24	and	and	CCONJ
aiua-13516	39	25	biological	biological	ADJ
aiua-13516	39	26	process	process	NOUN
aiua-13516	39	27	to	to	PART
aiua-13516	39	28	describe	describe	VERB
aiua-13516	39	29	their	their	PRON
aiua-13516	39	30	different	different	ADJ
aiua-13516	39	31	functions	function	NOUN
aiua-13516	39	32	and	and	CCONJ
aiua-13516	39	33	interactions	interaction	NOUN
aiua-13516	39	34	within	within	ADP
aiua-13516	39	35	cells	cell	NOUN
aiua-13516	39	36	.	.	PUNCT
aiua-13516	40	1	kegg	kegg	NOUN
aiua-13516	40	2	analysis	analysis	NOUN
aiua-13516	40	3	is	be	AUX
aiua-13516	40	4	a	a	DET
aiua-13516	40	5	functional	functional	ADJ
aiua-13516	40	6	annotation	annotation	NOUN
aiua-13516	40	7	method	method	NOUN
aiua-13516	40	8	based	base	VERB
aiua-13516	40	9	on	on	ADP
aiua-13516	40	10	metabolic	metabolic	NOUN
aiua-13516	40	11	pathways	pathway	NOUN
aiua-13516	40	12	and	and	CCONJ
aiua-13516	40	13	biological	biological	ADJ
aiua-13516	40	14	signaling	signal	VERB
aiua-13516	40	15	networks	network	NOUN
aiua-13516	40	16	.	.	PUNCT
aiua-13516	41	1	by	by	ADP
aiua-13516	41	2	correlating	correlate	VERB
aiua-13516	41	3	genes	gene	NOUN
aiua-13516	41	4	or	or	CCONJ
aiua-13516	41	5	proteins	protein	NOUN
aiua-13516	41	6	with	with	ADP
aiua-13516	41	7	metabolic	metabolic	NOUN
aiua-13516	41	8	pathways	pathway	NOUN
aiua-13516	41	9	and	and	CCONJ
aiua-13516	41	10	signaling	signal	VERB
aiua-13516	41	11	networks	network	NOUN
aiua-13516	41	12	in	in	ADP
aiua-13516	41	13	kegg	kegg	NOUN
aiua-13516	41	14	databases	database	NOUN
aiua-13516	41	15	,	,	PUNCT
aiua-13516	41	16	it	it	PRON
aiua-13516	41	17	is	be	AUX
aiua-13516	41	18	possible	possible	ADJ
aiua-13516	41	19	to	to	PART
aiua-13516	41	20	understand	understand	VERB
aiua-13516	41	21	their	their	PRON
aiua-13516	41	22	functional	functional	ADJ
aiua-13516	41	23	roles	role	NOUN
aiua-13516	41	24	and	and	CCONJ
aiua-13516	41	25	interrelationships	interrelationship	NOUN
aiua-13516	41	26	in	in	ADP
aiua-13516	41	27	the	the	DET
aiua-13516	41	28	cells	cell	NOUN
aiua-13516	41	29	.	.	PUNCT
aiua-13516	42	1	to	to	PART
aiua-13516	42	2	obtain	obtain	VERB
aiua-13516	42	3	the	the	DET
aiua-13516	42	4	pathways	pathway	NOUN
aiua-13516	42	5	used	use	VERB
aiua-13516	42	6	in	in	ADP
aiua-13516	42	7	gene	gene	NOUN
aiua-13516	42	8	set	set	VERB
aiua-13516	42	9	variation	variation	NOUN
aiua-13516	42	10	analysis	analysis	NOUN
aiua-13516	42	11	(	(	PUNCT
aiua-13516	42	12	gsva	gsva	NOUN
aiua-13516	42	13	)	)	PUNCT
aiua-13516	42	14	,	,	PUNCT
aiua-13516	42	15	the	the	DET
aiua-13516	42	16	hallmark	hallmark	ADJ
aiua-13516	42	17	,	,	PUNCT
aiua-13516	42	18	reactome	reactome	NOUN
aiua-13516	42	19	,	,	PUNCT
aiua-13516	42	20	and	and	CCONJ
aiua-13516	42	21	kegg	kegg	NOUN
aiua-13516	42	22	pathways	pathway	NOUN
aiua-13516	42	23	were	be	AUX
aiua-13516	42	24	downloaded	download	VERB
aiua-13516	42	25	from	from	ADP
aiua-13516	42	26	version	version	NOUN
aiua-13516	42	27	7.5.1	7.5.1	NUM
aiua-13516	42	28	of	of	ADP
aiua-13516	42	29	the	the	DET
aiua-13516	42	30	msigdb	msigdb	PROPN
aiua-13516	42	31	database	database	NOUN
aiua-13516	42	32	.	.	PUNCT
aiua-13516	43	1	the	the	DET
aiua-13516	43	2	r	r	NOUN
aiua-13516	43	3	package	package	NOUN
aiua-13516	43	4	"	"	PUNCT
aiua-13516	43	5	gsva	gsva	NOUN
aiua-13516	43	6	"	"	PUNCT
aiua-13516	43	7	was	be	AUX
aiua-13516	43	8	used	use	VERB
aiua-13516	43	9	to	to	PART
aiua-13516	43	10	calculate	calculate	VERB
aiua-13516	43	11	the	the	DET
aiua-13516	43	12	pathway	pathway	NOUN
aiua-13516	43	13	score	score	NOUN
aiua-13516	43	14	for	for	ADP
aiua-13516	43	15	each	each	DET
aiua-13516	43	16	sample	sample	NOUN
aiua-13516	43	17	.	.	PUNCT
aiua-13516	44	1	the	the	DET
aiua-13516	44	2	r	r	NOUN
aiua-13516	44	3	package	package	NOUN
aiua-13516	44	4	"	"	PUNCT
aiua-13516	44	5	clusterprofiler	clusterprofiler	NOUN
aiua-13516	44	6	"	"	PUNCT
aiua-13516	44	7	was	be	AUX
aiua-13516	44	8	used	use	VERB
aiua-13516	44	9	to	to	PART
aiua-13516	44	10	carry	carry	VERB
aiua-13516	44	11	out	out	ADP
aiua-13516	44	12	go	go	VERB
aiua-13516	44	13	and	and	CCONJ
aiua-13516	44	14	kegg	kegg	VERB
aiua-13516	44	15	analysis	analysis	NOUN
aiua-13516	44	16	of	of	ADP
aiua-13516	44	17	degs	deg	NOUN
aiua-13516	44	18	.	.	PUNCT
aiua-13516	45	1	immune	immune	ADJ
aiua-13516	45	2	cell	cell	NOUN
aiua-13516	45	3	infiltration	infiltration	NOUN
aiua-13516	45	4	analysis	analysis	NOUN
aiua-13516	45	5	the	the	DET
aiua-13516	45	6	r	r	NOUN
aiua-13516	45	7	package	package	NOUN
aiua-13516	45	8	"	"	PUNCT
aiua-13516	45	9	estimate	estimate	NOUN
aiua-13516	45	10	"	"	PUNCT
aiua-13516	45	11	was	be	AUX
aiua-13516	45	12	used	use	VERB
aiua-13516	45	13	to	to	PART
aiua-13516	45	14	assess	assess	VERB
aiua-13516	45	15	the	the	DET
aiua-13516	45	16	blca	blca	ADJ
aiua-13516	45	17	samples	sample	NOUN
aiua-13516	45	18	'	'	PART
aiua-13516	45	19	tumor	tumor	NOUN
aiua-13516	45	20	microenvironment	microenvironment	NOUN
aiua-13516	45	21	,	,	PUNCT
aiua-13516	45	22	including	include	VERB
aiua-13516	45	23	stromal	stromal	ADJ
aiua-13516	45	24	score	score	NOUN
aiua-13516	45	25	,	,	PUNCT
aiua-13516	45	26	immune	immune	ADJ
aiua-13516	45	27	score	score	NOUN
aiua-13516	45	28	,	,	PUNCT
aiua-13516	45	29	and	and	CCONJ
aiua-13516	45	30	estimate	estimate	VERB
aiua-13516	45	31	score	score	NOUN
aiua-13516	45	32	.	.	PUNCT
aiua-13516	46	1	in	in	ADP
aiua-13516	46	2	order	order	NOUN
aiua-13516	46	3	to	to	PART
aiua-13516	46	4	measure	measure	VERB
aiua-13516	46	5	the	the	DET
aiua-13516	46	6	23	23	NUM
aiua-13516	46	7	immune	immune	ADJ
aiua-13516	46	8	cell	cell	NOUN
aiua-13516	46	9	infiltrations	infiltration	NOUN
aiua-13516	46	10	,	,	PUNCT
aiua-13516	46	11	the	the	DET
aiua-13516	46	12	gsva	gsva	ADJ
aiua-13516	46	13	r	r	NOUN
aiua-13516	46	14	package	package	NOUN
aiua-13516	46	15	's	's	PART
aiua-13516	46	16	ssgsea	ssgsea	NOUN
aiua-13516	46	17	function	function	NOUN
aiua-13516	46	18	was	be	AUX
aiua-13516	46	19	used	use	VERB
aiua-13516	46	20	.	.	PUNCT
aiua-13516	47	1	following	follow	VERB
aiua-13516	47	2	that	that	PRON
aiua-13516	47	3	,	,	PUNCT
aiua-13516	47	4	the	the	DET
aiua-13516	47	5	various	various	ADJ
aiua-13516	47	6	groups	group	NOUN
aiua-13516	47	7	were	be	AUX
aiua-13516	47	8	compared	compare	VERB
aiua-13516	47	9	based	base	VERB
aiua-13516	47	10	on	on	ADP
aiua-13516	47	11	their	their	PRON
aiua-13516	47	12	immune	immune	ADJ
aiua-13516	47	13	cell	cell	NOUN
aiua-13516	47	14	level	level	NOUN
aiua-13516	47	15	.	.	PUNCT
aiua-13516	48	1	construction	construction	NOUN
aiua-13516	48	2	of	of	ADP
aiua-13516	48	3	lactylation	lactylation	NOUN
aiua-13516	48	4	score	score	NOUN
aiua-13516	48	5	using	use	VERB
aiua-13516	48	6	the	the	DET
aiua-13516	48	7	r	r	NOUN
aiua-13516	48	8	package	package	NOUN
aiua-13516	48	9	"	"	PUNCT
aiua-13516	48	10	limma	limma	NOUN
aiua-13516	48	11	"	"	PUNCT
aiua-13516	48	12	,	,	PUNCT
aiua-13516	48	13	we	we	PRON
aiua-13516	48	14	identified	identify	VERB
aiua-13516	48	15	275	275	NUM
aiua-13516	48	16	degs	deg	NOUN
aiua-13516	48	17	distinguishing	distinguish	VERB
aiua-13516	48	18	between	between	ADP
aiua-13516	48	19	cluster	cluster	NOUN
aiua-13516	48	20	a	a	PRON
aiua-13516	48	21	and	and	CCONJ
aiua-13516	48	22	b	b	NOUN
aiua-13516	48	23	with	with	ADP
aiua-13516	48	24	|logfc|	|logfc|	PROPN
aiua-13516	48	25	>	>	SYM
aiua-13516	48	26	0.5	0.5	NUM
aiua-13516	48	27	and	and	CCONJ
aiua-13516	48	28	p	p	X
aiua-13516	48	29	<	<	X
aiua-13516	48	30	0.05	0.05	NUM
aiua-13516	48	31	.	.	PUNCT
aiua-13516	49	1	subsequently	subsequently	ADV
aiua-13516	49	2	,	,	PUNCT
aiua-13516	49	3	we	we	PRON
aiua-13516	49	4	conducted	conduct	VERB
aiua-13516	49	5	univariate	univariate	ADJ
aiua-13516	49	6	regression	regression	NOUN
aiua-13516	49	7	analysis	analysis	NOUN
aiua-13516	49	8	,	,	PUNCT
aiua-13516	49	9	which	which	PRON
aiua-13516	49	10	revealed	reveal	VERB
aiua-13516	49	11	11	11	NUM
aiua-13516	49	12	degs	deg	NOUN
aiua-13516	49	13	significantly	significantly	ADV
aiua-13516	49	14	associated	associate	VERB
aiua-13516	49	15	with	with	ADP
aiua-13516	49	16	overall	overall	ADJ
aiua-13516	49	17	survival	survival	NOUN
aiua-13516	49	18	at	at	ADP
aiua-13516	49	19	p	p	NOUN
aiua-13516	49	20	<	<	X
aiua-13516	49	21	0.001	0.001	NUM
aiua-13516	49	22	.	.	PUNCT
aiua-13516	50	1	based	base	VERB
aiua-13516	50	2	on	on	ADP
aiua-13516	50	3	these	these	DET
aiua-13516	50	4	11	11	NUM
aiua-13516	50	5	degs	deg	NOUN
aiua-13516	50	6	,	,	PUNCT
aiua-13516	50	7	we	we	PRON
aiua-13516	50	8	performed	perform	VERB
aiua-13516	50	9	principal	principal	ADJ
aiua-13516	50	10	component	component	NOUN
aiua-13516	50	11	analysis	analysis	NOUN
aiua-13516	50	12	(	(	PUNCT
aiua-13516	50	13	pca	pca	NOUN
aiua-13516	50	14	)	)	PUNCT
aiua-13516	50	15	.	.	PUNCT
aiua-13516	51	1	using	use	VERB
aiua-13516	51	2	principal	principal	ADJ
aiua-13516	51	3	components	component	NOUN
aiua-13516	51	4	1	1	NUM
aiua-13516	51	5	and	and	CCONJ
aiua-13516	51	6	2	2	NUM
aiua-13516	51	7	,	,	PUNCT
aiua-13516	51	8	we	we	PRON
aiua-13516	51	9	constructed	construct	VERB
aiua-13516	51	10	the	the	DET
aiua-13516	51	11	lactylation	lactylation	NOUN
aiua-13516	51	12	score	score	NOUN
aiua-13516	51	13	(	(	PUNCT
aiua-13516	51	14	19	19	NUM
aiua-13516	51	15	)	)	PUNCT
aiua-13516	51	16	.	.	PUNCT
aiua-13516	52	1	statistical	statistical	ADJ
aiua-13516	52	2	analysis	analysis	NOUN
aiua-13516	52	3	all	all	DET
aiua-13516	52	4	data	datum	NOUN
aiua-13516	52	5	are	be	AUX
aiua-13516	52	6	presented	present	VERB
aiua-13516	52	7	as	as	ADP
aiua-13516	52	8	the	the	DET
aiua-13516	52	9	mean	mean	PROPN
aiua-13516	52	10	±	±	NUM
aiua-13516	52	11	standard	standard	ADJ
aiua-13516	52	12	deviation	deviation	NOUN
aiua-13516	52	13	(	(	PUNCT
aiua-13516	52	14	sd	sd	NOUN
aiua-13516	52	15	)	)	PUNCT
aiua-13516	52	16	.	.	PUNCT
aiua-13516	53	1	statistical	statistical	ADJ
aiua-13516	53	2	analysis	analysis	NOUN
aiua-13516	53	3	was	be	AUX
aiua-13516	53	4	performed	perform	VERB
aiua-13516	53	5	using	use	VERB
aiua-13516	53	6	r	r	NOUN
aiua-13516	53	7	software	software	NOUN
aiua-13516	53	8	(	(	PUNCT
aiua-13516	53	9	https://www.r-project.org/	https://www.r-project.org/	ADV
aiua-13516	53	10	,	,	PUNCT
aiua-13516	53	11	version:4.1.1	version:4.1.1	NOUN
aiua-13516	53	12	)	)	PUNCT
aiua-13516	53	13	.	.	PUNCT
aiua-13516	54	1	p	p	X
aiua-13516	54	2	<	<	X
aiua-13516	54	3	0.05	0.05	NUM
aiua-13516	54	4	(	(	PUNCT
aiua-13516	54	5	two	two	NUM
aiua-13516	54	6	-	-	PUNCT
aiua-13516	54	7	tailed	tail	VERB
aiua-13516	54	8	)	)	PUNCT
aiua-13516	54	9	was	be	AUX
aiua-13516	54	10	considered	consider	VERB
aiua-13516	54	11	statistically	statistically	ADV
aiua-13516	54	12	significant	significant	ADJ
aiua-13516	54	13	:	:	PUNCT
aiua-13516	54	14	*	*	PUNCT
aiua-13516	54	15	p	p	X
aiua-13516	54	16	<	<	X
aiua-13516	54	17	0.05	0.05	NUM
aiua-13516	54	18	,	,	PUNCT
aiua-13516	54	19	*	*	PUNCT
aiua-13516	54	20	*	*	PUNCT
aiua-13516	54	21	p	p	X
aiua-13516	54	22	<	<	X
aiua-13516	54	23	0.01	0.01	NUM
aiua-13516	54	24	,	,	PUNCT
aiua-13516	54	25	*	*	PUNCT
aiua-13516	54	26	*	*	PUNCT
aiua-13516	54	27	*	*	PUNCT
aiua-13516	54	28	p	p	X
aiua-13516	54	29	<	<	X
aiua-13516	54	30	0.001	0.001	NUM
aiua-13516	54	31	,	,	PUNCT
aiua-13516	54	32	and	and	CCONJ
aiua-13516	54	33	*	*	PUNCT
aiua-13516	54	34	*	*	PUNCT
aiua-13516	54	35	*	*	PUNCT
aiua-13516	54	36	*	*	PUNCT
aiua-13516	54	37	p	p	X
aiua-13516	54	38	<	<	X
aiua-13516	54	39	0.0001	0.0001	NUM
aiua-13516	54	40	.	.	PUNCT
aiua-13516	55	1	results	result	VERB
aiua-13516	55	2	identification	identification	NOUN
aiua-13516	55	3	of	of	ADP
aiua-13516	55	4	lactylation	lactylation	NOUN
aiua-13516	55	5	genes	gene	NOUN
aiua-13516	55	6	-	-	PUNCT
aiua-13516	55	7	related	relate	VERB
aiua-13516	55	8	subtypes	subtype	NOUN
aiua-13516	55	9	of	of	ADP
aiua-13516	55	10	blca	blca	NOUN
aiua-13516	55	11	the	the	DET
aiua-13516	55	12	flow	flow	NOUN
aiua-13516	55	13	chart	chart	NOUN
aiua-13516	55	14	of	of	ADP
aiua-13516	55	15	the	the	DET
aiua-13516	55	16	study	study	NOUN
aiua-13516	55	17	is	be	AUX
aiua-13516	55	18	show	show	NOUN
aiua-13516	55	19	in	in	ADP
aiua-13516	55	20	figure	figure	NOUN
aiua-13516	55	21	1	1	NUM
aiua-13516	55	22	.	.	PUNCT
aiua-13516	56	1	at	at	ADP
aiua-13516	56	2	first	first	ADV
aiua-13516	56	3	,	,	PUNCT
aiua-13516	56	4	we	we	PRON
aiua-13516	56	5	combined	combine	VERB
aiua-13516	56	6	the	the	DET
aiua-13516	56	7	expression	expression	NOUN
aiua-13516	56	8	profiles	profile	NOUN
aiua-13516	56	9	of	of	ADP
aiua-13516	56	10	tumor	tumor	NOUN
aiua-13516	56	11	tissues	tissue	NOUN
aiua-13516	56	12	from	from	ADP
aiua-13516	56	13	tcga	tcga	NOUN
aiua-13516	56	14	-	-	PUNCT
aiua-13516	56	15	blca	blca	NOUN
aiua-13516	56	16	and	and	CCONJ
aiua-13516	56	17	gse13507	gse13507	NOUN
aiua-13516	56	18	,	,	PUNCT
aiua-13516	56	19	and	and	CCONJ
aiua-13516	56	20	then	then	ADV
aiua-13516	56	21	used	use	VERB
aiua-13516	56	22	univariate	univariate	ADJ
aiua-13516	56	23	cox	cox	PROPN
aiua-13516	56	24	regression	regression	NOUN
aiua-13516	56	25	and	and	CCONJ
aiua-13516	56	26	kaplan	kaplan	PROPN
aiua-13516	56	27	-	-	PUNCT
aiua-13516	56	28	meier	meier	PROPN
aiua-13516	56	29	analysis	analysis	NOUN
aiua-13516	56	30	to	to	PART
aiua-13516	56	31	evaluate	evaluate	VERB
aiua-13516	56	32	the	the	DET
aiua-13516	56	33	prognostic	prognostic	ADJ
aiua-13516	56	34	significance	significance	NOUN
aiua-13516	56	35	of	of	ADP
aiua-13516	56	36	lactylation	lactylation	NOUN
aiua-13516	56	37	genes	gene	NOUN
aiua-13516	56	38	(	(	PUNCT
aiua-13516	56	39	supplementary	supplementary	ADJ
aiua-13516	56	40	table	table	NOUN
aiua-13516	56	41	s2	s2	PROPN
aiua-13516	56	42	)	)	PUNCT
aiua-13516	56	43	.	.	PUNCT
aiua-13516	57	1	figure	figure	NOUN
aiua-13516	57	2	2a	2a	NUM
aiua-13516	57	3	depicts	depict	VERB
aiua-13516	57	4	the	the	DET
aiua-13516	57	5	results	result	NOUN
aiua-13516	57	6	of	of	ADP
aiua-13516	57	7	univariate	univariate	ADJ
aiua-13516	57	8	cox	cox	PROPN
aiua-13516	57	9	regression	regression	NOUN
aiua-13516	57	10	and	and	CCONJ
aiua-13516	57	11	correlation	correlation	NOUN
aiua-13516	57	12	analysis	analysis	NOUN
aiua-13516	57	13	of	of	ADP
aiua-13516	57	14	lactylation	lactylation	NOUN
aiua-13516	57	15	genes	gene	NOUN
aiua-13516	57	16	.	.	PUNCT
aiua-13516	58	1	10	10	NUM
aiua-13516	58	2	lactylation	lactylation	NOUN
aiua-13516	58	3	genes	gene	NOUN
aiua-13516	58	4	were	be	AUX
aiua-13516	58	5	revealed	reveal	VERB
aiua-13516	58	6	to	to	PART
aiua-13516	58	7	have	have	VERB
aiua-13516	58	8	some	some	DET
aiua-13516	58	9	correlation	correlation	NOUN
aiua-13516	58	10	with	with	ADP
aiua-13516	58	11	each	each	DET
aiua-13516	58	12	other	other	ADJ
aiua-13516	58	13	.	.	PUNCT
aiua-13516	59	1	among	among	ADP
aiua-13516	59	2	them	they	PRON
aiua-13516	59	3	,	,	PUNCT
aiua-13516	59	4	9	9	NUM
aiua-13516	59	5	genes	gene	NOUN
aiua-13516	59	6	were	be	AUX
aiua-13516	59	7	identified	identify	VERB
aiua-13516	59	8	as	as	ADP
aiua-13516	59	9	risk	risk	NOUN
aiua-13516	59	10	factors	factor	NOUN
aiua-13516	59	11	and	and	CCONJ
aiua-13516	59	12	one	one	NUM
aiua-13516	59	13	was	be	AUX
aiua-13516	59	14	favorable	favorable	ADJ
aiua-13516	59	15	factor	factor	NOUN
aiua-13516	59	16	.	.	PUNCT
aiua-13516	60	1	while	while	SCONJ
aiua-13516	60	2	figure	figure	NOUN
aiua-13516	60	3	2b	2b	NOUN
aiua-13516	60	4	illustrates	illustrate	VERB
aiua-13516	60	5	7	7	NUM
aiua-13516	60	6	lactylation	lactylation	NOUN
aiua-13516	60	7	genes	gene	NOUN
aiua-13516	60	8	that	that	PRON
aiua-13516	60	9	were	be	AUX
aiua-13516	60	10	significantly	significantly	ADV
aiua-13516	60	11	associated	associate	VERB
aiua-13516	60	12	with	with	ADP
aiua-13516	60	13	the	the	DET
aiua-13516	60	14	prognosis	prognosis	NOUN
aiua-13516	60	15	of	of	ADP
aiua-13516	60	16	blca	blca	ADJ
aiua-13516	60	17	patients	patient	NOUN
aiua-13516	60	18	revealed	reveal	VERB
aiua-13516	60	19	by	by	ADP
aiua-13516	60	20	kaplan	kaplan	PROPN
aiua-13516	60	21	-	-	PUNCT
aiua-13516	60	22	meier	meier	PROPN
aiua-13516	60	23	analyses	analysis	NOUN
aiua-13516	60	24	.	.	PUNCT
aiua-13516	61	1	next	next	ADV
aiua-13516	61	2	,	,	PUNCT
aiua-13516	61	3	we	we	PRON
aiua-13516	61	4	divided	divide	VERB
aiua-13516	61	5	blca	blca	NOUN
aiua-13516	61	6	into	into	ADP
aiua-13516	61	7	two	two	NUM
aiua-13516	61	8	subtypes	subtype	NOUN
aiua-13516	61	9	,	,	PUNCT
aiua-13516	61	10	cluster	cluster	NOUN
aiua-13516	61	11	a	a	PRON
aiua-13516	61	12	and	and	CCONJ
aiua-13516	61	13	b	b	NOUN
aiua-13516	61	14	,	,	PUNCT
aiua-13516	61	15	based	base	VERB
aiua-13516	61	16	on	on	ADP
aiua-13516	61	17	the	the	DET
aiua-13516	61	18	expression	expression	NOUN
aiua-13516	61	19	pattern	pattern	NOUN
aiua-13516	61	20	of	of	ADP
aiua-13516	61	21	lactylation	lactylation	NOUN
aiua-13516	61	22	genes	gene	NOUN
aiua-13516	61	23	(	(	PUNCT
aiua-13516	61	24	figure	figure	NOUN
aiua-13516	61	25	3a	3a	NUM
aiua-13516	61	26	)	)	PUNCT
aiua-13516	61	27	,	,	PUNCT
aiua-13516	61	28	and	and	CCONJ
aiua-13516	61	29	found	find	VERB
aiua-13516	61	30	that	that	SCONJ
aiua-13516	61	31	there	there	PRON
aiua-13516	61	32	was	be	VERB
aiua-13516	61	33	a	a	DET
aiua-13516	61	34	clear	clear	ADJ
aiua-13516	61	35	distinction	distinction	NOUN
aiua-13516	61	36	between	between	ADP
aiua-13516	61	37	cluster	cluster	NOUN
aiua-13516	61	38	a	a	NOUN
aiua-13516	61	39	and	and	CCONJ
aiua-13516	61	40	b	b	NOUN
aiua-13516	61	41	according	accord	VERB
aiua-13516	61	42	to	to	ADP
aiua-13516	61	43	the	the	DET
aiua-13516	61	44	pca	pca	PROPN
aiua-13516	61	45	plot	plot	NOUN
aiua-13516	61	46	(	(	PUNCT
aiua-13516	61	47	figure	figure	NOUN
aiua-13516	61	48	3b	3b	NUM
aiua-13516	61	49	)	)	PUNCT
aiua-13516	61	50	.	.	PUNCT
aiua-13516	62	1	we	we	PRON
aiua-13516	62	2	also	also	ADV
aiua-13516	62	3	presented	present	VERB
aiua-13516	62	4	the	the	DET
aiua-13516	62	5	distribution	distribution	NOUN
aiua-13516	62	6	of	of	ADP
aiua-13516	62	7	clinical	clinical	ADJ
aiua-13516	62	8	features	feature	NOUN
aiua-13516	62	9	and	and	CCONJ
aiua-13516	62	10	lactylation	lactylation	NOUN
aiua-13516	62	11	gene	gene	NOUN
aiua-13516	62	12	expression	expression	NOUN
aiua-13516	62	13	in	in	ADP
aiua-13516	62	14	each	each	DET
aiua-13516	62	15	cluster	cluster	NOUN
aiua-13516	62	16	(	(	PUNCT
aiua-13516	62	17	figure	figure	NOUN
aiua-13516	62	18	3c	3c	NUM
aiua-13516	62	19	,	,	PUNCT
aiua-13516	62	20	d	d	NOUN
aiua-13516	62	21	)	)	PUNCT
aiua-13516	62	22	.	.	PUNCT
aiua-13516	63	1	furthermore	furthermore	ADV
aiua-13516	63	2	,	,	PUNCT
aiua-13516	63	3	we	we	PRON
aiua-13516	63	4	assessed	assess	VERB
aiua-13516	63	5	the	the	DET
aiua-13516	63	6	immune	immune	ADJ
aiua-13516	63	7	infiltration	infiltration	NOUN
aiua-13516	63	8	in	in	ADP
aiua-13516	63	9	blca	blca	ADJ
aiua-13516	63	10	samples	sample	NOUN
aiua-13516	63	11	,	,	PUNCT
aiua-13516	63	12	and	and	CCONJ
aiua-13516	63	13	found	find	VERB
aiua-13516	63	14	that	that	SCONJ
aiua-13516	63	15	the	the	DET
aiua-13516	63	16	stromalscore	stromalscore	NOUN
aiua-13516	63	17	,	,	PUNCT
aiua-13516	63	18	immunescore	immunescore	NOUN
aiua-13516	63	19	,	,	PUNCT
aiua-13516	63	20	and	and	CCONJ
aiua-13516	63	21	estimatescore	estimatescore	NOUN
aiua-13516	63	22	were	be	AUX
aiua-13516	63	23	all	all	ADV
aiua-13516	63	24	higher	high	ADJ
aiua-13516	63	25	in	in	ADP
aiua-13516	63	26	cluster	cluster	NOUN
aiua-13516	63	27	a	a	DET
aiua-13516	63	28	(	(	PUNCT
aiua-13516	63	29	figure	figure	NOUN
aiua-13516	63	30	3e	3e	NOUN
aiua-13516	63	31	)	)	PUNCT
aiua-13516	63	32	,	,	PUNCT
aiua-13516	63	33	and	and	CCONJ
aiua-13516	63	34	most	most	ADJ
aiua-13516	63	35	immune	immune	ADJ
aiua-13516	63	36	cell	cell	NOUN
aiua-13516	63	37	levels	level	NOUN
aiua-13516	63	38	were	be	AUX
aiua-13516	63	39	more	more	ADV
aiua-13516	63	40	highly	highly	ADV
aiua-13516	63	41	infiltrated	infiltrate	VERB
aiua-13516	63	42	in	in	ADP
aiua-13516	63	43	cluster	cluster	NOUN
aiua-13516	63	44	a	a	PRON
aiua-13516	63	45	than	than	ADP
aiua-13516	63	46	in	in	ADP
aiua-13516	63	47	cluster	cluster	NOUN
aiua-13516	63	48	b	b	PROPN
aiua-13516	63	49	(	(	PUNCT
aiua-13516	63	50	figure	figure	NOUN
aiua-13516	63	51	3f	3f	PROPN
aiua-13516	63	52	)	)	PUNCT
aiua-13516	63	53	.	.	PUNCT
aiua-13516	64	1	we	we	PRON
aiua-13516	64	2	also	also	ADV
aiua-13516	64	3	investigated	investigate	VERB
aiua-13516	64	4	the	the	DET
aiua-13516	64	5	differences	difference	NOUN
aiua-13516	64	6	between	between	ADP
aiua-13516	64	7	the	the	DET
aiua-13516	64	8	two	two	NUM
aiua-13516	64	9	clusters	cluster	NOUN
aiua-13516	64	10	in	in	ADP
aiua-13516	64	11	terms	term	NOUN
aiua-13516	64	12	of	of	ADP
aiua-13516	64	13	various	various	ADJ
aiua-13516	64	14	pathways	pathway	NOUN
aiua-13516	64	15	using	use	VERB
aiua-13516	64	16	gsva	gsva	NOUN
aiua-13516	64	17	.	.	PUNCT
aiua-13516	65	1	we	we	PRON
aiua-13516	65	2	discovered	discover	VERB
aiua-13516	65	3	that	that	SCONJ
aiua-13516	65	4	most	most	ADJ
aiua-13516	65	5	of	of	ADP
aiua-13516	65	6	the	the	DET
aiua-13516	65	7	hallmark	hallmark	ADJ
aiua-13516	65	8	pathways	pathway	NOUN
aiua-13516	65	9	,	,	PUNCT
aiua-13516	65	10	kegg	kegg	NOUN
aiua-13516	65	11	pathways	pathway	NOUN
aiua-13516	65	12	,	,	PUNCT
aiua-13516	65	13	and	and	CCONJ
aiua-13516	65	14	reactome	reactome	NOUN
aiua-13516	65	15	pathways	pathway	NOUN
aiua-13516	65	16	had	have	VERB
aiua-13516	65	17	higher	high	ADJ
aiua-13516	65	18	scores	score	NOUN
aiua-13516	65	19	in	in	ADP
aiua-13516	65	20	cluster	cluster	NOUN
aiua-13516	65	21	b	b	PROPN
aiua-13516	65	22	(	(	PUNCT
aiua-13516	65	23	supplementary	supplementary	ADJ
aiua-13516	65	24	figure	figure	NOUN
aiua-13516	65	25	s1	s1	NOUN
aiua-13516	65	26	)	)	PUNCT
aiua-13516	65	27	.	.	PUNCT
aiua-13516	66	1	for	for	ADP
aiua-13516	66	2	hallmark	hallmark	ADJ
aiua-13516	66	3	pathways	pathway	NOUN
aiua-13516	66	4	,	,	PUNCT
aiua-13516	66	5	the	the	DET
aiua-13516	66	6	scores	score	NOUN
aiua-13516	66	7	tgf	tgf	PROPN
aiua-13516	66	8	beta	beta	ADJ
aiua-13516	66	9	signaling	signal	VERB
aiua-13516	66	10	pathway	pathway	NOUN
aiua-13516	66	11	and	and	CCONJ
aiua-13516	66	12	mtorc1	mtorc1	NOUN
aiua-13516	66	13	signaling	signal	VERB
aiua-13516	66	14	pathway	pathway	NOUN
aiua-13516	66	15	were	be	AUX
aiua-13516	66	16	higher	high	ADJ
aiua-13516	66	17	in	in	ADP
aiua-13516	66	18	cluster	cluster	NOUN
aiua-13516	66	19	b.	b.	PROPN
aiua-13516	66	20	for	for	ADP
aiua-13516	66	21	kegg	kegg	NOUN
aiua-13516	66	22	,	,	PUNCT
aiua-13516	66	23	the	the	DET
aiua-13516	66	24	scores	score	NOUN
aiua-13516	66	25	of	of	ADP
aiua-13516	66	26	tgf	tgf	PROPN
aiua-13516	66	27	beta	beta	ADJ
aiua-13516	66	28	signaling	signal	VERB
aiua-13516	66	29	pathway	pathway	NOUN
aiua-13516	66	30	,	,	PUNCT
aiua-13516	66	31	wnt	wnt	PROPN
aiua-13516	66	32	signaling	signal	VERB
aiua-13516	66	33	archivio	archivio	NOUN
aiua-13516	66	34	italiano	italiano	X
aiua-13516	66	35	di	di	X
aiua-13516	66	36	urologia	urologia	PROPN
aiua-13516	66	37	e	e	PROPN
aiua-13516	66	38	andrologia	andrologia	NOUN
aiua-13516	66	39	2025	2025	NUM
aiua-13516	66	40	;	;	PUNCT
aiua-13516	66	41	97(1):13516	97(1):13516	NUM
aiua-13516	66	42	3	3	NUM
aiua-13516	66	43	lactylation	lactylation	NOUN
aiua-13516	66	44	-	-	PUNCT
aiua-13516	66	45	related	relate	VERB
aiua-13516	66	46	gene	gene	NOUN
aiua-13516	66	47	signature	signature	NOUN
aiua-13516	66	48	in	in	ADP
aiua-13516	66	49	bladder	bladder	NOUN
aiua-13516	66	50	cancer	cancer	NOUN
aiua-13516	66	51	pathway	pathway	NOUN
aiua-13516	66	52	,	,	PUNCT
aiua-13516	66	53	and	and	CCONJ
aiua-13516	66	54	mtor	mtor	PROPN
aiua-13516	66	55	signaling	signal	VERB
aiua-13516	66	56	pathwaywere	pathwaywere	NOUN
aiua-13516	66	57	higher	high	ADJ
aiua-13516	66	58	in	in	ADP
aiua-13516	66	59	cluster	cluster	PROPN
aiua-13516	66	60	b.	b.	PROPN
aiua-13516	66	61	for	for	ADP
aiua-13516	66	62	reactome	reactome	NOUN
aiua-13516	66	63	results	result	NOUN
aiua-13516	66	64	,	,	PUNCT
aiua-13516	66	65	most	most	ADJ
aiua-13516	66	66	pathways	pathway	NOUN
aiua-13516	66	67	were	be	AUX
aiua-13516	66	68	observed	observe	VERB
aiua-13516	66	69	to	to	PART
aiua-13516	66	70	be	be	AUX
aiua-13516	66	71	higher	high	ADJ
aiua-13516	66	72	in	in	ADP
aiua-13516	66	73	cluster	cluster	NOUN
aiua-13516	66	74	b.	b.	NOUN
aiua-13516	66	75	these	these	DET
aiua-13516	66	76	findings	finding	NOUN
aiua-13516	66	77	suggested	suggest	VERB
aiua-13516	66	78	that	that	SCONJ
aiua-13516	66	79	the	the	DET
aiua-13516	66	80	biggest	big	ADJ
aiua-13516	66	81	difference	difference	NOUN
aiua-13516	66	82	between	between	ADP
aiua-13516	66	83	the	the	DET
aiua-13516	66	84	two	two	NUM
aiua-13516	66	85	subtypes	subtype	NOUN
aiua-13516	66	86	was	be	AUX
aiua-13516	66	87	in	in	ADP
aiua-13516	66	88	the	the	DET
aiua-13516	66	89	pathways	pathway	NOUN
aiua-13516	66	90	associated	associate	VERB
aiua-13516	66	91	with	with	ADP
aiua-13516	66	92	carcinogenesis	carcinogenesis	NOUN
aiua-13516	66	93	.	.	PUNCT
aiua-13516	67	1	identification	identification	NOUN
aiua-13516	67	2	of	of	ADP
aiua-13516	67	3	gene	gene	NOUN
aiua-13516	67	4	subtypes	subtype	NOUN
aiua-13516	67	5	and	and	CCONJ
aiua-13516	67	6	construction	construction	NOUN
aiua-13516	67	7	of	of	ADP
aiua-13516	67	8	lactylation	lactylation	NOUN
aiua-13516	67	9	score	score	NOUN
aiua-13516	67	10	by	by	ADP
aiua-13516	67	11	employing	employ	VERB
aiua-13516	67	12	the	the	DET
aiua-13516	67	13	"	"	PUNCT
aiua-13516	67	14	limma	limma	NOUN
aiua-13516	67	15	"	"	PUNCT
aiua-13516	67	16	package	package	NOUN
aiua-13516	67	17	,	,	PUNCT
aiua-13516	67	18	275	275	NUM
aiua-13516	67	19	degs	deg	NOUN
aiua-13516	67	20	were	be	AUX
aiua-13516	67	21	screened	screen	VERB
aiua-13516	67	22	between	between	ADP
aiua-13516	67	23	cluster	cluster	NOUN
aiua-13516	67	24	a	a	NOUN
aiua-13516	67	25	and	and	CCONJ
aiua-13516	67	26	cluster	cluster	NOUN
aiua-13516	67	27	b	b	PROPN
aiua-13516	67	28	(	(	PUNCT
aiua-13516	67	29	figure	figure	NOUN
aiua-13516	67	30	4a	4a	NUM
aiua-13516	67	31	)	)	PUNCT
aiua-13516	67	32	.	.	PUNCT
aiua-13516	68	1	the	the	DET
aiua-13516	68	2	go	go	NOUN
aiua-13516	68	3	enrichment	enrichment	NOUN
aiua-13516	68	4	analysis	analysis	NOUN
aiua-13516	68	5	highlighted	highlight	VERB
aiua-13516	68	6	that	that	SCONJ
aiua-13516	68	7	these	these	DET
aiua-13516	68	8	degs	deg	NOUN
aiua-13516	68	9	were	be	AUX
aiua-13516	68	10	enriched	enrich	VERB
aiua-13516	68	11	in	in	ADP
aiua-13516	68	12	cell	cell	NOUN
aiua-13516	68	13	growth	growth	NOUN
aiua-13516	68	14	and	and	CCONJ
aiua-13516	68	15	g1	g1	PROPN
aiua-13516	68	16	/	/	SYM
aiua-13516	68	17	s	s	PART
aiua-13516	68	18	transition	transition	NOUN
aiua-13516	68	19	of	of	ADP
aiua-13516	68	20	mitotic	mitotic	ADJ
aiua-13516	68	21	cell	cell	NOUN
aiua-13516	68	22	cycle	cycle	NOUN
aiua-13516	68	23	in	in	ADP
aiua-13516	68	24	biological	biological	ADJ
aiua-13516	68	25	process	process	NOUN
aiua-13516	68	26	(	(	PUNCT
aiua-13516	68	27	bp	bp	PROPN
aiua-13516	68	28	)	)	PUNCT
aiua-13516	68	29	,	,	PUNCT
aiua-13516	68	30	cell	cell	NOUN
aiua-13516	68	31	leading	leading	ADJ
aiua-13516	68	32	edge	edge	NOUN
aiua-13516	68	33	and	and	CCONJ
aiua-13516	68	34	nuclear	nuclear	ADJ
aiua-13516	68	35	speck	speck	NOUN
aiua-13516	68	36	in	in	ADP
aiua-13516	68	37	cellular	cellular	ADJ
aiua-13516	68	38	component	component	NOUN
aiua-13516	68	39	(	(	PUNCT
aiua-13516	68	40	cc	cc	NOUN
aiua-13516	68	41	)	)	PUNCT
aiua-13516	68	42	,	,	PUNCT
aiua-13516	68	43	and	and	CCONJ
aiua-13516	68	44	dna−binding	dna−binde	VERB
aiua-13516	68	45	transcription	transcription	NOUN
aiua-13516	68	46	factor	factor	NOUN
aiua-13516	68	47	binding	bind	VERB
aiua-13516	68	48	in	in	ADP
aiua-13516	68	49	molecular	molecular	ADJ
aiua-13516	68	50	function	function	NOUN
aiua-13516	68	51	(	(	PUNCT
aiua-13516	68	52	mf	mf	X
aiua-13516	68	53	)	)	PUNCT
aiua-13516	68	54	(	(	PUNCT
aiua-13516	68	55	figure	figure	VERB
aiua-13516	68	56	4b	4b	PROPN
aiua-13516	68	57	-	-	PUNCT
aiua-13516	68	58	d	d	NOUN
aiua-13516	68	59	)	)	PUNCT
aiua-13516	68	60	.	.	PUNCT
aiua-13516	69	1	in	in	ADP
aiua-13516	69	2	terms	term	NOUN
aiua-13516	69	3	of	of	ADP
aiua-13516	69	4	kegg	kegg	NOUN
aiua-13516	69	5	,	,	PUNCT
aiua-13516	69	6	the	the	DET
aiua-13516	69	7	degs	deg	NOUN
aiua-13516	69	8	were	be	AUX
aiua-13516	69	9	predominantly	predominantly	ADV
aiua-13516	69	10	enriched	enrich	VERB
aiua-13516	69	11	in	in	ADP
aiua-13516	69	12	cell	cell	NOUN
aiua-13516	69	13	cycle	cycle	NOUN
aiua-13516	69	14	,	,	PUNCT
aiua-13516	69	15	p53	p53	NOUN
aiua-13516	69	16	signaling	signal	VERB
aiua-13516	69	17	pathway	pathway	NOUN
aiua-13516	69	18	,	,	PUNCT
aiua-13516	69	19	and	and	CCONJ
aiua-13516	69	20	nicotinate	nicotinate	ADJ
aiua-13516	69	21	and	and	CCONJ
aiua-13516	69	22	nicotinamide	nicotinamide	NOUN
aiua-13516	69	23	metabolism	metabolism	NOUN
aiua-13516	69	24	(	(	PUNCT
aiua-13516	69	25	figure	figure	NOUN
aiua-13516	69	26	4e	4e	PROPN
aiua-13516	69	27	)	)	PUNCT
aiua-13516	69	28	.	.	PUNCT
aiua-13516	70	1	furthermore	furthermore	ADV
aiua-13516	70	2	,	,	PUNCT
aiua-13516	70	3	we	we	PRON
aiua-13516	70	4	utilized	utilize	VERB
aiua-13516	70	5	univariate	univariate	ADJ
aiua-13516	70	6	cox	cox	PROPN
aiua-13516	70	7	regression	regression	NOUN
aiua-13516	70	8	analysis	analysis	NOUN
aiua-13516	70	9	to	to	PART
aiua-13516	70	10	determine	determine	VERB
aiua-13516	70	11	the	the	DET
aiua-13516	70	12	prognostic	prognostic	ADJ
aiua-13516	70	13	significance	significance	NOUN
aiua-13516	70	14	of	of	ADP
aiua-13516	70	15	the	the	DET
aiua-13516	70	16	275	275	NUM
aiua-13516	70	17	degs	deg	NOUN
aiua-13516	70	18	and	and	CCONJ
aiua-13516	70	19	identified	identify	VERB
aiua-13516	70	20	11	11	NUM
aiua-13516	70	21	genes	gene	NOUN
aiua-13516	70	22	associated	associate	VERB
aiua-13516	70	23	with	with	ADP
aiua-13516	70	24	overall	overall	ADJ
aiua-13516	70	25	survival	survival	NOUN
aiua-13516	70	26	(	(	PUNCT
aiua-13516	70	27	p	p	X
aiua-13516	70	28	<	<	X
aiua-13516	70	29	0.001	0.001	NUM
aiua-13516	70	30	)	)	PUNCT
aiua-13516	70	31	(	(	PUNCT
aiua-13516	70	32	figure	figure	NOUN
aiua-13516	70	33	5a	5a	NUM
aiua-13516	70	34	,	,	PUNCT
aiua-13516	70	35	supplementary	supplementary	ADJ
aiua-13516	70	36	table	table	NOUN
aiua-13516	70	37	s3	s3	PROPN
aiua-13516	70	38	)	)	PUNCT
aiua-13516	70	39	.	.	PUNCT
aiua-13516	71	1	to	to	PART
aiua-13516	71	2	confirm	confirm	VERB
aiua-13516	71	3	above	above	ADP
aiua-13516	71	4	findings	finding	NOUN
aiua-13516	71	5	,	,	PUNCT
aiua-13516	71	6	unsupervised	unsupervised	ADJ
aiua-13516	71	7	clustering	clustering	NOUN
aiua-13516	71	8	separated	separate	VERB
aiua-13516	71	9	patients	patient	NOUN
aiua-13516	71	10	into	into	ADP
aiua-13516	71	11	two	two	NUM
aiua-13516	71	12	subtypes	subtype	NOUN
aiua-13516	71	13	based	base	VERB
aiua-13516	71	14	on	on	ADP
aiua-13516	71	15	these	these	DET
aiua-13516	71	16	11	11	NUM
aiua-13516	71	17	prognostic	prognostic	ADJ
aiua-13516	71	18	genes	gene	NOUN
aiua-13516	71	19	,	,	PUNCT
aiua-13516	71	20	genecluster	genecluster	NOUN
aiua-13516	71	21	a	a	NOUN
aiua-13516	71	22	-	-	PUNCT
aiua-13516	71	23	b	b	NOUN
aiua-13516	71	24	(	(	PUNCT
aiua-13516	71	25	figure	figure	NOUN
aiua-13516	71	26	5b	5b	NUM
aiua-13516	71	27	)	)	PUNCT
aiua-13516	71	28	.	.	PUNCT
aiua-13516	72	1	patients	patient	NOUN
aiua-13516	72	2	categorized	categorize	VERB
aiua-13516	72	3	in	in	ADP
aiua-13516	72	4	genecluster	genecluster	NOUN
aiua-13516	72	5	a	a	PRON
aiua-13516	72	6	had	have	VERB
aiua-13516	72	7	worse	bad	ADJ
aiua-13516	72	8	survival	survival	NOUN
aiua-13516	72	9	rates	rate	NOUN
aiua-13516	72	10	compared	compare	VERB
aiua-13516	72	11	to	to	ADP
aiua-13516	72	12	those	those	PRON
aiua-13516	72	13	in	in	ADP
aiua-13516	72	14	genecluster	genecluster	NOUN
aiua-13516	72	15	b	b	PROPN
aiua-13516	72	16	(	(	PUNCT
aiua-13516	72	17	figure	figure	NOUN
aiua-13516	72	18	5c	5c	NUM
aiua-13516	72	19	)	)	PUNCT
aiua-13516	72	20	.	.	PUNCT
aiua-13516	73	1	the	the	DET
aiua-13516	73	2	expression	expression	NOUN
aiua-13516	73	3	of	of	ADP
aiua-13516	73	4	the	the	DET
aiua-13516	73	5	11	11	NUM
aiua-13516	73	6	lactylation	lactylation	NOUN
aiua-13516	73	7	-	-	PUNCT
aiua-13516	73	8	related	relate	VERB
aiua-13516	73	9	genes	gene	NOUN
aiua-13516	73	10	was	be	AUX
aiua-13516	73	11	depicted	depict	VERB
aiua-13516	73	12	in	in	ADP
aiua-13516	73	13	figure	figure	NOUN
aiua-13516	73	14	5d	5d	NUM
aiua-13516	73	15	,	,	PUNCT
aiua-13516	73	16	while	while	SCONJ
aiua-13516	73	17	figure	figure	NOUN
aiua-13516	73	18	5e	5e	NOUN
aiua-13516	73	19	showed	show	VERB
aiua-13516	73	20	the	the	DET
aiua-13516	73	21	distribution	distribution	NOUN
aiua-13516	73	22	of	of	ADP
aiua-13516	73	23	clinical	clinical	ADJ
aiua-13516	73	24	features	feature	NOUN
aiua-13516	73	25	and	and	CCONJ
aiua-13516	73	26	expression	expression	NOUN
aiua-13516	73	27	of	of	ADP
aiua-13516	73	28	the	the	DET
aiua-13516	73	29	11	11	NUM
aiua-13516	73	30	prognostic	prognostic	ADJ
aiua-13516	73	31	genes	gene	NOUN
aiua-13516	73	32	in	in	ADP
aiua-13516	73	33	the	the	DET
aiua-13516	73	34	two	two	NUM
aiua-13516	73	35	geneclusters	genecluster	NOUN
aiua-13516	73	36	.	.	PUNCT
aiua-13516	74	1	using	use	VERB
aiua-13516	74	2	the	the	DET
aiua-13516	74	3	pca	pca	NOUN
aiua-13516	74	4	algorithm	algorithm	NOUN
aiua-13516	74	5	,	,	PUNCT
aiua-13516	74	6	the	the	DET
aiua-13516	74	7	11	11	NUM
aiua-13516	74	8	prognostic	prognostic	ADJ
aiua-13516	74	9	genes	gene	NOUN
aiua-13516	74	10	were	be	AUX
aiua-13516	74	11	used	use	VERB
aiua-13516	74	12	to	to	PART
aiua-13516	74	13	establish	establish	VERB
aiua-13516	74	14	the	the	DET
aiua-13516	74	15	lactyfigure	lactyfigure	NOUN
aiua-13516	74	16	1	1	NUM
aiua-13516	74	17	.	.	PUNCT
aiua-13516	75	1	flow	flow	NOUN
aiua-13516	75	2	chart	chart	NOUN
aiua-13516	75	3	of	of	ADP
aiua-13516	75	4	the	the	DET
aiua-13516	75	5	study	study	NOUN
aiua-13516	75	6	.	.	PUNCT
aiua-13516	76	1	archivio	archivio	NOUN
aiua-13516	76	2	italiano	italiano	PROPN
aiua-13516	76	3	di	di	PROPN
aiua-13516	76	4	urologia	urologia	PROPN
aiua-13516	76	5	e	e	PROPN
aiua-13516	76	6	andrologia	andrologia	NOUN
aiua-13516	76	7	2025	2025	NUM
aiua-13516	76	8	;	;	PUNCT
aiua-13516	76	9	97(1):13516	97(1):13516	NUM
aiua-13516	76	10	g.	g.	PROPN
aiua-13516	76	11	liu	liu	PROPN
aiua-13516	76	12	,	,	PUNCT
aiua-13516	76	13	t.	t.	PROPN
aiua-13516	76	14	hong	hong	PROPN
aiua-13516	76	15	,	,	PUNCT
aiua-13516	76	16	x.	x.	PROPN
aiua-13516	76	17	liu	liu	PROPN
aiua-13516	76	18	,	,	PUNCT
aiua-13516	76	19	et	et	PROPN
aiua-13516	76	20	al	al	PROPN
aiua-13516	76	21	.	.	PROPN
aiua-13516	76	22	4	4	NUM
aiua-13516	76	23	lation	lation	NOUN
aiua-13516	76	24	score	score	NOUN
aiua-13516	76	25	.	.	PUNCT
aiua-13516	77	1	figure	figure	NOUN
aiua-13516	77	2	5f	5f	PROPN
aiua-13516	77	3	suggested	suggest	VERB
aiua-13516	77	4	that	that	SCONJ
aiua-13516	77	5	patients	patient	NOUN
aiua-13516	77	6	with	with	ADP
aiua-13516	77	7	a	a	DET
aiua-13516	77	8	high	high	ADJ
aiua-13516	77	9	lactylation	lactylation	NOUN
aiua-13516	77	10	score	score	NOUN
aiua-13516	77	11	have	have	VERB
aiua-13516	77	12	worse	bad	ADJ
aiua-13516	77	13	survival	survival	NOUN
aiua-13516	77	14	.	.	PUNCT
aiua-13516	78	1	the	the	DET
aiua-13516	78	2	correlation	correlation	NOUN
aiua-13516	78	3	between	between	ADP
aiua-13516	78	4	cluster	cluster	NOUN
aiua-13516	78	5	,	,	PUNCT
aiua-13516	78	6	genecluster	genecluster	NOUN
aiua-13516	78	7	,	,	PUNCT
aiua-13516	78	8	lactylation	lactylation	NOUN
aiua-13516	78	9	score	score	NOUN
aiua-13516	78	10	,	,	PUNCT
aiua-13516	78	11	and	and	CCONJ
aiua-13516	78	12	survival	survival	NOUN
aiua-13516	78	13	status	status	NOUN
aiua-13516	78	14	is	be	AUX
aiua-13516	78	15	depicted	depict	VERB
aiua-13516	78	16	in	in	ADP
aiua-13516	78	17	figure	figure	NOUN
aiua-13516	78	18	5	5	NUM
aiua-13516	78	19	g	g	NOUN
aiua-13516	78	20	using	use	VERB
aiua-13516	78	21	a	a	DET
aiua-13516	78	22	sankey	sankey	ADJ
aiua-13516	78	23	diagram	diagram	NOUN
aiua-13516	78	24	.	.	PUNCT
aiua-13516	79	1	we	we	PRON
aiua-13516	79	2	analyzed	analyze	VERB
aiua-13516	79	3	the	the	DET
aiua-13516	79	4	correlation	correlation	NOUN
aiua-13516	79	5	of	of	ADP
aiua-13516	79	6	lactylation	lactylation	NOUN
aiua-13516	79	7	score	score	NOUN
aiua-13516	79	8	with	with	ADP
aiua-13516	79	9	immune	immune	ADJ
aiua-13516	79	10	cell	cell	NOUN
aiua-13516	79	11	infiltration	infiltration	NOUN
aiua-13516	79	12	and	and	CCONJ
aiua-13516	79	13	found	find	VERB
aiua-13516	79	14	that	that	SCONJ
aiua-13516	79	15	patients	patient	NOUN
aiua-13516	79	16	with	with	ADP
aiua-13516	79	17	high	high	ADJ
aiua-13516	79	18	lactylation	lactylation	NOUN
aiua-13516	79	19	score	score	NOUN
aiua-13516	79	20	have	have	VERB
aiua-13516	79	21	elevated	elevate	VERB
aiua-13516	79	22	immune	immune	ADJ
aiua-13516	79	23	cell	cell	NOUN
aiua-13516	79	24	infiltration	infiltration	NOUN
aiua-13516	79	25	level	level	NOUN
aiua-13516	79	26	(	(	PUNCT
aiua-13516	79	27	figure	figure	NOUN
aiua-13516	79	28	5h	5h	NUM
aiua-13516	79	29	)	)	PUNCT
aiua-13516	79	30	.	.	PUNCT
aiua-13516	80	1	figure	figure	NOUN
aiua-13516	80	2	2	2	NUM
aiua-13516	80	3	.	.	PUNCT
aiua-13516	80	4	correlation	correlation	NOUN
aiua-13516	80	5	and	and	CCONJ
aiua-13516	80	6	prognostic	prognostic	ADJ
aiua-13516	80	7	value	value	NOUN
aiua-13516	80	8	of	of	ADP
aiua-13516	80	9	lactylation	lactylation	NOUN
aiua-13516	80	10	genes	gene	NOUN
aiua-13516	80	11	in	in	ADP
aiua-13516	80	12	blca	blca	ADJ
aiua-13516	80	13	:	:	PUNCT
aiua-13516	80	14	a.	a.	NOUN
aiua-13516	80	15	network	network	PROPN
aiua-13516	80	16	diagram	diagram	NOUN
aiua-13516	80	17	showing	show	VERB
aiua-13516	80	18	the	the	DET
aiua-13516	80	19	interaction	interaction	NOUN
aiua-13516	80	20	of	of	ADP
aiua-13516	80	21	lactylation	lactylation	NOUN
aiua-13516	80	22	genes	gene	NOUN
aiua-13516	80	23	in	in	ADP
aiua-13516	80	24	blca	blca	PROPN
aiua-13516	80	25	.	.	PUNCT
aiua-13516	81	1	the	the	DET
aiua-13516	81	2	line	line	NOUN
aiua-13516	81	3	connecting	connect	VERB
aiua-13516	81	4	the	the	DET
aiua-13516	81	5	lactylation	lactylation	NOUN
aiua-13516	81	6	genes	gene	NOUN
aiua-13516	81	7	represents	represent	VERB
aiua-13516	81	8	their	their	PRON
aiua-13516	81	9	correlation	correlation	NOUN
aiua-13516	81	10	,	,	PUNCT
aiua-13516	81	11	with	with	ADP
aiua-13516	81	12	the	the	DET
aiua-13516	81	13	line	line	NOUN
aiua-13516	81	14	thickness	thickness	NOUN
aiua-13516	81	15	indicating	indicate	VERB
aiua-13516	81	16	the	the	DET
aiua-13516	81	17	strength	strength	NOUN
aiua-13516	81	18	of	of	ADP
aiua-13516	81	19	the	the	DET
aiua-13516	81	20	correlation	correlation	NOUN
aiua-13516	81	21	between	between	ADP
aiua-13516	81	22	lactylation	lactylation	NOUN
aiua-13516	81	23	genes	gene	NOUN
aiua-13516	81	24	.	.	PUNCT
aiua-13516	82	1	blue	blue	ADJ
aiua-13516	82	2	and	and	CCONJ
aiua-13516	82	3	pink	pink	ADJ
aiua-13516	82	4	represent	represent	VERB
aiua-13516	82	5	negative	negative	ADJ
aiua-13516	82	6	and	and	CCONJ
aiua-13516	82	7	positive	positive	ADJ
aiua-13516	82	8	correlations	correlation	NOUN
aiua-13516	82	9	,	,	PUNCT
aiua-13516	82	10	respectively	respectively	ADV
aiua-13516	82	11	.	.	PUNCT
aiua-13516	83	1	b.	b.	PROPN
aiua-13516	83	2	kaplan	kaplan	PROPN
aiua-13516	83	3	-	-	PROPN
aiua-13516	83	4	meier	meier	PROPN
aiua-13516	83	5	analysis	analysis	NOUN
aiua-13516	83	6	of	of	ADP
aiua-13516	83	7	indicated	indicate	VERB
aiua-13516	83	8	genes	gene	NOUN
aiua-13516	83	9	.	.	PUNCT
aiua-13516	84	1	archivio	archivio	NOUN
aiua-13516	84	2	italiano	italiano	PROPN
aiua-13516	84	3	di	di	PROPN
aiua-13516	84	4	urologia	urologia	PROPN
aiua-13516	84	5	e	e	PROPN
aiua-13516	84	6	andrologia	andrologia	NOUN
aiua-13516	84	7	2025	2025	NUM
aiua-13516	84	8	;	;	PUNCT
aiua-13516	84	9	97(1):13516	97(1):13516	NUM
aiua-13516	84	10	5	5	NUM
aiua-13516	84	11	lactylation	lactylation	NOUN
aiua-13516	84	12	-	-	PUNCT
aiua-13516	84	13	related	relate	VERB
aiua-13516	84	14	gene	gene	NOUN
aiua-13516	84	15	signature	signature	NOUN
aiua-13516	84	16	in	in	ADP
aiua-13516	84	17	bladder	bladder	NOUN
aiua-13516	84	18	cancer	cancer	NOUN
aiua-13516	84	19	figure	figure	NOUN
aiua-13516	84	20	3	3	NUM
aiua-13516	84	21	.	.	PUNCT
aiua-13516	85	1	identification	identification	NOUN
aiua-13516	85	2	of	of	ADP
aiua-13516	85	3	lactylation	lactylation	NOUN
aiua-13516	85	4	genes	gene	NOUN
aiua-13516	85	5	-	-	PUNCT
aiua-13516	85	6	related	relate	VERB
aiua-13516	85	7	subtypes	subtype	NOUN
aiua-13516	85	8	of	of	ADP
aiua-13516	85	9	blca	blca	NOUN
aiua-13516	85	10	:	:	PUNCT
aiua-13516	85	11	a.	a.	NOUN
aiua-13516	85	12	consensus	consensus	PROPN
aiua-13516	85	13	matrix	matrix	NOUN
aiua-13516	85	14	heatmap	heatmap	NOUN
aiua-13516	85	15	defining	define	VERB
aiua-13516	85	16	various	various	ADJ
aiua-13516	85	17	clusters	cluster	NOUN
aiua-13516	85	18	and	and	CCONJ
aiua-13516	85	19	their	their	PRON
aiua-13516	85	20	correlation	correlation	NOUN
aiua-13516	85	21	area	area	NOUN
aiua-13516	85	22	.	.	PUNCT
aiua-13516	86	1	b.	b.	PROPN
aiua-13516	86	2	pca	pca	PROPN
aiua-13516	86	3	plot	plot	NOUN
aiua-13516	86	4	of	of	ADP
aiua-13516	86	5	blca	blca	ADJ
aiua-13516	86	6	patients	patient	NOUN
aiua-13516	86	7	in	in	ADP
aiua-13516	86	8	two	two	NUM
aiua-13516	86	9	clusters	cluster	NOUN
aiua-13516	86	10	.	.	PUNCT
aiua-13516	87	1	c.	c.	NOUN
aiua-13516	87	2	distributions	distribution	NOUN
aiua-13516	87	3	of	of	ADP
aiua-13516	87	4	clinical	clinical	ADJ
aiua-13516	87	5	features	feature	NOUN
aiua-13516	87	6	and	and	CCONJ
aiua-13516	87	7	expression	expression	NOUN
aiua-13516	87	8	levels	level	NOUN
aiua-13516	87	9	of	of	ADP
aiua-13516	87	10	lactylation	lactylation	NOUN
aiua-13516	87	11	genes	gene	NOUN
aiua-13516	87	12	between	between	ADP
aiua-13516	87	13	two	two	NUM
aiua-13516	87	14	clusters	cluster	NOUN
aiua-13516	87	15	.	.	PUNCT
aiua-13516	88	1	d.	d.	NOUN
aiua-13516	88	2	the	the	DET
aiua-13516	88	3	expression	expression	NOUN
aiua-13516	88	4	of	of	ADP
aiua-13516	88	5	lactylation	lactylation	NOUN
aiua-13516	88	6	genes	gene	NOUN
aiua-13516	88	7	in	in	ADP
aiua-13516	88	8	cluster	cluster	NOUN
aiua-13516	88	9	a	a	PRON
aiua-13516	88	10	and	and	CCONJ
aiua-13516	88	11	cluster	cluster	PROPN
aiua-13516	88	12	b.	b.	PROPN
aiua-13516	88	13	e.	e.	PROPN
aiua-13516	89	1	the	the	DET
aiua-13516	89	2	tumor	tumor	NOUN
aiua-13516	89	3	microenvironment	microenvironment	ADJ
aiua-13516	89	4	difference	difference	NOUN
aiua-13516	89	5	in	in	ADP
aiua-13516	89	6	two	two	NUM
aiua-13516	89	7	clusters	cluster	NOUN
aiua-13516	89	8	.	.	PUNCT
aiua-13516	90	1	f.	f.	PROPN
aiua-13516	91	1	the	the	DET
aiua-13516	91	2	difference	difference	NOUN
aiua-13516	91	3	of	of	ADP
aiua-13516	91	4	immune	immune	ADJ
aiua-13516	91	5	cell	cell	NOUN
aiua-13516	91	6	infiltration	infiltration	NOUN
aiua-13516	91	7	level	level	NOUN
aiua-13516	91	8	in	in	ADP
aiua-13516	91	9	two	two	NUM
aiua-13516	91	10	clusters	cluster	NOUN
aiua-13516	91	11	.	.	PUNCT
aiua-13516	92	1	archivio	archivio	NOUN
aiua-13516	92	2	italiano	italiano	PROPN
aiua-13516	92	3	di	di	PROPN
aiua-13516	92	4	urologia	urologia	PROPN
aiua-13516	92	5	e	e	PROPN
aiua-13516	92	6	andrologia	andrologia	NOUN
aiua-13516	92	7	2025	2025	NUM
aiua-13516	92	8	;	;	PUNCT
aiua-13516	92	9	97(1):13516	97(1):13516	NUM
aiua-13516	92	10	g.	g.	PROPN
aiua-13516	92	11	liu	liu	PROPN
aiua-13516	92	12	,	,	PUNCT
aiua-13516	92	13	t.	t.	PROPN
aiua-13516	92	14	hong	hong	PROPN
aiua-13516	92	15	,	,	PUNCT
aiua-13516	92	16	x.	x.	PROPN
aiua-13516	92	17	liu	liu	PROPN
aiua-13516	92	18	,	,	PUNCT
aiua-13516	92	19	et	et	PROPN
aiua-13516	92	20	al	al	PROPN
aiua-13516	92	21	.	.	PROPN
aiua-13516	92	22	6	6	NUM
aiua-13516	92	23	figure	figure	NOUN
aiua-13516	92	24	4	4	NUM
aiua-13516	92	25	.	.	PUNCT
aiua-13516	92	26	enrichment	enrichment	NOUN
aiua-13516	92	27	analysis	analysis	NOUN
aiua-13516	92	28	of	of	ADP
aiua-13516	92	29	degs	deg	NOUN
aiua-13516	92	30	between	between	ADP
aiua-13516	92	31	two	two	NUM
aiua-13516	92	32	lactylation	lactylation	NOUN
aiua-13516	92	33	subtypes	subtype	NOUN
aiua-13516	92	34	:	:	PUNCT
aiua-13516	92	35	a.	a.	NOUN
aiua-13516	92	36	volcanic	volcanic	ADJ
aiua-13516	92	37	map	map	NOUN
aiua-13516	92	38	of	of	ADP
aiua-13516	92	39	degs	deg	NOUN
aiua-13516	92	40	between	between	ADP
aiua-13516	92	41	two	two	NUM
aiua-13516	92	42	clusters	cluster	NOUN
aiua-13516	92	43	.	.	PUNCT
aiua-13516	93	1	b	b	X
aiua-13516	93	2	-	-	PUNCT
aiua-13516	93	3	d.	d.	NOUN
aiua-13516	93	4	go	go	VERB
aiua-13516	93	5	enrichment	enrichment	NOUN
aiua-13516	93	6	analysis	analysis	NOUN
aiua-13516	93	7	of	of	ADP
aiua-13516	93	8	degs	deg	NOUN
aiua-13516	93	9	,	,	PUNCT
aiua-13516	93	10	including	include	VERB
aiua-13516	93	11	bp	bp	PROPN
aiua-13516	93	12	,	,	PUNCT
aiua-13516	93	13	cc	cc	NOUN
aiua-13516	93	14	,	,	PUNCT
aiua-13516	93	15	and	and	CCONJ
aiua-13516	93	16	mf	mf	PROPN
aiua-13516	93	17	.	.	PROPN
aiua-13516	93	18	e.	e.	PROPN
aiua-13516	94	1	the	the	DET
aiua-13516	94	2	correlation	correlation	NOUN
aiua-13516	94	3	of	of	ADP
aiua-13516	94	4	degs	deg	NOUN
aiua-13516	94	5	with	with	ADP
aiua-13516	94	6	top5	top5	ADJ
aiua-13516	94	7	terms	term	NOUN
aiua-13516	94	8	of	of	ADP
aiua-13516	94	9	kegg	kegg	NOUN
aiua-13516	94	10	results	result	NOUN
aiua-13516	94	11	.	.	PUNCT
aiua-13516	95	1	archivio	archivio	NOUN
aiua-13516	95	2	italiano	italiano	X
aiua-13516	95	3	di	di	PROPN
aiua-13516	95	4	urologia	urologia	PROPN
aiua-13516	95	5	e	e	PROPN
aiua-13516	95	6	andrologia	andrologia	NOUN
aiua-13516	95	7	2025	2025	NUM
aiua-13516	95	8	;	;	PUNCT
aiua-13516	95	9	97(1):13516	97(1):13516	NUM
aiua-13516	95	10	7	7	NUM
aiua-13516	95	11	lactylation	lactylation	NOUN
aiua-13516	95	12	-	-	PUNCT
aiua-13516	95	13	related	relate	VERB
aiua-13516	95	14	gene	gene	NOUN
aiua-13516	95	15	signature	signature	NOUN
aiua-13516	95	16	in	in	ADP
aiua-13516	95	17	bladder	bladder	NOUN
aiua-13516	95	18	cancer	cancer	NOUN
aiua-13516	95	19	genetic	genetic	ADJ
aiua-13516	95	20	alteration	alteration	NOUN
aiua-13516	95	21	of	of	ADP
aiua-13516	95	22	prognostic	prognostic	ADJ
aiua-13516	95	23	genes	gene	NOUN
aiua-13516	95	24	we	we	PRON
aiua-13516	95	25	further	far	ADV
aiua-13516	95	26	explored	explore	VERB
aiua-13516	95	27	the	the	DET
aiua-13516	95	28	expression	expression	NOUN
aiua-13516	95	29	and	and	CCONJ
aiua-13516	95	30	genetic	genetic	ADJ
aiua-13516	95	31	alterations	alteration	NOUN
aiua-13516	95	32	of	of	ADP
aiua-13516	95	33	11	11	NUM
aiua-13516	95	34	prognostic	prognostic	ADJ
aiua-13516	95	35	genes	gene	NOUN
aiua-13516	95	36	.	.	PUNCT
aiua-13516	96	1	the	the	DET
aiua-13516	96	2	snv	snv	PROPN
aiua-13516	96	3	frequency	frequency	NOUN
aiua-13516	96	4	of	of	ADP
aiua-13516	96	5	these	these	DET
aiua-13516	96	6	genes	gene	NOUN
aiua-13516	96	7	was	be	AUX
aiua-13516	96	8	generally	generally	ADV
aiua-13516	96	9	low	low	ADJ
aiua-13516	96	10	,	,	PUNCT
aiua-13516	96	11	with	with	ADP
aiua-13516	96	12	tbx3	tbx3	PROPN
aiua-13516	96	13	having	have	VERB
aiua-13516	96	14	the	the	DET
aiua-13516	96	15	highest	high	ADJ
aiua-13516	96	16	snv	snv	NOUN
aiua-13516	96	17	frequency	frequency	NOUN
aiua-13516	96	18	(	(	PUNCT
aiua-13516	96	19	supplementary	supplementary	ADJ
aiua-13516	96	20	figure	figure	NOUN
aiua-13516	96	21	s2a	s2a	NOUN
aiua-13516	96	22	-	-	PUNCT
aiua-13516	96	23	b	b	NOUN
aiua-13516	96	24	)	)	PUNCT
aiua-13516	96	25	.	.	PUNCT
aiua-13516	97	1	supplementary	supplementary	ADJ
aiua-13516	97	2	figure	figure	NOUN
aiua-13516	97	3	s3a	s3a	PUNCT
aiua-13516	97	4	displays	display	VERB
aiua-13516	97	5	the	the	DET
aiua-13516	97	6	percentage	percentage	NOUN
aiua-13516	97	7	of	of	ADP
aiua-13516	97	8	copy	copy	NOUN
aiua-13516	97	9	number	number	NOUN
aiua-13516	97	10	variation	variation	NOUN
aiua-13516	97	11	(	(	PUNCT
aiua-13516	97	12	cnv	cnv	NOUN
aiua-13516	97	13	)	)	PUNCT
aiua-13516	97	14	for	for	ADP
aiua-13516	97	15	each	each	DET
aiua-13516	97	16	gene	gene	NOUN
aiua-13516	97	17	.	.	PUNCT
aiua-13516	98	1	tp53inp1	tp53inp1	PROPN
aiua-13516	98	2	had	have	VERB
aiua-13516	98	3	the	the	DET
aiua-13516	98	4	highest	high	ADJ
aiua-13516	98	5	amplification	amplification	NOUN
aiua-13516	98	6	cnv	cnv	NOUN
aiua-13516	98	7	frequency	frequency	NOUN
aiua-13516	98	8	,	,	PUNCT
aiua-13516	98	9	while	while	SCONJ
aiua-13516	98	10	lgals1	lgals1	NOUN
aiua-13516	98	11	showed	show	VERB
aiua-13516	98	12	a	a	DET
aiua-13516	98	13	significant	significant	ADJ
aiua-13516	98	14	figure	figure	NOUN
aiua-13516	98	15	5	5	NUM
aiua-13516	98	16	.	.	PUNCT
aiua-13516	99	1	construction	construction	NOUN
aiua-13516	99	2	of	of	ADP
aiua-13516	99	3	lactylation	lactylation	NOUN
aiua-13516	99	4	score	score	NOUN
aiua-13516	99	5	in	in	ADP
aiua-13516	99	6	blca	blca	ADJ
aiua-13516	99	7	:	:	PUNCT
aiua-13516	99	8	a.	a.	NOUN
aiua-13516	99	9	forest	forest	PROPN
aiua-13516	99	10	plot	plot	NOUN
aiua-13516	99	11	presenting	present	VERB
aiua-13516	99	12	results	result	NOUN
aiua-13516	99	13	of	of	ADP
aiua-13516	99	14	univariate	univariate	ADJ
aiua-13516	99	15	cox	cox	PROPN
aiua-13516	99	16	regression	regression	PROPN
aiua-13516	99	17	analysis	analysis	NOUN
aiua-13516	99	18	.	.	PUNCT
aiua-13516	100	1	b.	b.	PROPN
aiua-13516	100	2	consensus	consensus	PROPN
aiua-13516	100	3	matrix	matrix	NOUN
aiua-13516	100	4	heatmap	heatmap	NOUN
aiua-13516	100	5	defining	define	VERB
aiua-13516	100	6	various	various	ADJ
aiua-13516	100	7	clusters	cluster	NOUN
aiua-13516	100	8	and	and	CCONJ
aiua-13516	100	9	their	their	PRON
aiua-13516	100	10	correlation	correlation	NOUN
aiua-13516	100	11	area	area	NOUN
aiua-13516	100	12	.	.	PUNCT
aiua-13516	101	1	c.	c.	PROPN
aiua-13516	101	2	kaplan	kaplan	PROPN
aiua-13516	101	3	-	-	PROPN
aiua-13516	101	4	meier	meier	PROPN
aiua-13516	101	5	analysis	analysis	NOUN
aiua-13516	101	6	of	of	ADP
aiua-13516	101	7	blca	blca	ADJ
aiua-13516	101	8	patients	patient	NOUN
aiua-13516	101	9	in	in	ADP
aiua-13516	101	10	two	two	NUM
aiua-13516	101	11	geneclusters	genecluster	NOUN
aiua-13516	101	12	.	.	PUNCT
aiua-13516	102	1	d.	d.	NOUN
aiua-13516	102	2	the	the	DET
aiua-13516	102	3	expression	expression	NOUN
aiua-13516	102	4	of	of	ADP
aiua-13516	102	5	indicated	indicate	VERB
aiua-13516	102	6	genes	gene	NOUN
aiua-13516	102	7	in	in	ADP
aiua-13516	102	8	two	two	NUM
aiua-13516	102	9	geneclusters	genecluster	NOUN
aiua-13516	102	10	.	.	PUNCT
aiua-13516	103	1	e.	e.	PROPN
aiua-13516	103	2	distributions	distribution	NOUN
aiua-13516	103	3	of	of	ADP
aiua-13516	103	4	clinical	clinical	ADJ
aiua-13516	103	5	features	feature	NOUN
aiua-13516	103	6	and	and	CCONJ
aiua-13516	103	7	expression	expression	NOUN
aiua-13516	103	8	levels	level	NOUN
aiua-13516	103	9	of	of	ADP
aiua-13516	103	10	11	11	NUM
aiua-13516	103	11	degs	deg	NOUN
aiua-13516	103	12	between	between	ADP
aiua-13516	103	13	the	the	DET
aiua-13516	103	14	two	two	NUM
aiua-13516	103	15	geneclusters	genecluster	NOUN
aiua-13516	103	16	.	.	PUNCT
aiua-13516	104	1	f.	f.	PROPN
aiua-13516	104	2	kaplan	kaplan	PROPN
aiua-13516	104	3	-	-	PROPN
aiua-13516	104	4	meier	meier	PROPN
aiua-13516	104	5	analysis	analysis	NOUN
aiua-13516	104	6	of	of	ADP
aiua-13516	104	7	lactylation	lactylation	NOUN
aiua-13516	104	8	score	score	NOUN
aiua-13516	104	9	in	in	ADP
aiua-13516	104	10	blca	blca	PROPN
aiua-13516	104	11	.	.	PUNCT
aiua-13516	105	1	g.	g.	VERB
aiua-13516	105	2	the	the	DET
aiua-13516	105	3	sankey	sankey	PROPN
aiua-13516	105	4	diagram	diagram	PROPN
aiua-13516	105	5	visualized	visualize	VERB
aiua-13516	105	6	the	the	DET
aiua-13516	105	7	correlation	correlation	NOUN
aiua-13516	105	8	between	between	ADP
aiua-13516	105	9	cluster	cluster	NOUN
aiua-13516	105	10	,	,	PUNCT
aiua-13516	105	11	genecluster	genecluster	NOUN
aiua-13516	105	12	,	,	PUNCT
aiua-13516	105	13	lactylation	lactylation	NOUN
aiua-13516	105	14	score	score	NOUN
aiua-13516	105	15	,	,	PUNCT
aiua-13516	105	16	and	and	CCONJ
aiua-13516	105	17	survival	survival	NOUN
aiua-13516	105	18	status	status	NOUN
aiua-13516	105	19	of	of	ADP
aiua-13516	105	20	blca	blca	ADJ
aiua-13516	105	21	patients	patient	NOUN
aiua-13516	105	22	.	.	PUNCT
aiua-13516	106	1	h.	h.	NOUN
aiua-13516	106	2	the	the	DET
aiua-13516	106	3	correlation	correlation	NOUN
aiua-13516	106	4	between	between	ADP
aiua-13516	106	5	lactylation	lactylation	NOUN
aiua-13516	106	6	score	score	NOUN
aiua-13516	106	7	and	and	CCONJ
aiua-13516	106	8	immune	immune	ADJ
aiua-13516	106	9	cell	cell	NOUN
aiua-13516	106	10	infiltration	infiltration	NOUN
aiua-13516	106	11	.	.	PUNCT
aiua-13516	107	1	red	red	ADJ
aiua-13516	107	2	color	color	NOUN
aiua-13516	107	3	represents	represent	VERB
aiua-13516	107	4	positive	positive	ADJ
aiua-13516	107	5	correlation	correlation	NOUN
aiua-13516	107	6	,	,	PUNCT
aiua-13516	107	7	blue	blue	ADJ
aiua-13516	107	8	color	color	NOUN
aiua-13516	107	9	represents	represent	VERB
aiua-13516	107	10	negative	negative	ADJ
aiua-13516	107	11	correlation	correlation	NOUN
aiua-13516	107	12	.	.	PUNCT
aiua-13516	108	1	archivio	archivio	NOUN
aiua-13516	108	2	italiano	italiano	PROPN
aiua-13516	108	3	di	di	PROPN
aiua-13516	108	4	urologia	urologia	PROPN
aiua-13516	108	5	e	e	PROPN
aiua-13516	108	6	andrologia	andrologia	NOUN
aiua-13516	108	7	2025	2025	NUM
aiua-13516	108	8	;	;	PUNCT
aiua-13516	108	9	97(1):13516	97(1):13516	NUM
aiua-13516	108	10	g.	g.	PROPN
aiua-13516	108	11	liu	liu	PROPN
aiua-13516	108	12	,	,	PUNCT
aiua-13516	108	13	t.	t.	PROPN
aiua-13516	108	14	hong	hong	PROPN
aiua-13516	108	15	,	,	PUNCT
aiua-13516	108	16	x.	x.	PROPN
aiua-13516	108	17	liu	liu	PROPN
aiua-13516	108	18	,	,	PUNCT
aiua-13516	108	19	et	et	PROPN
aiua-13516	108	20	al	al	PROPN
aiua-13516	108	21	.	.	PROPN
aiua-13516	108	22	8	8	NUM
aiua-13516	108	23	cnv	cnv	NOUN
aiua-13516	108	24	deletion	deletion	NOUN
aiua-13516	108	25	.	.	PUNCT
aiua-13516	109	1	we	we	PRON
aiua-13516	109	2	also	also	ADV
aiua-13516	109	3	represented	represent	VERB
aiua-13516	109	4	the	the	DET
aiua-13516	109	5	percentage	percentage	NOUN
aiua-13516	109	6	of	of	ADP
aiua-13516	109	7	heterozygous	heterozygous	ADJ
aiua-13516	109	8	and	and	CCONJ
aiua-13516	109	9	homozygous	homozygous	ADJ
aiua-13516	109	10	cnv	cnv	NOUN
aiua-13516	109	11	of	of	ADP
aiua-13516	109	12	each	each	DET
aiua-13516	109	13	gene	gene	NOUN
aiua-13516	109	14	in	in	ADP
aiua-13516	109	15	blca	blca	PROPN
aiua-13516	109	16	,	,	PUNCT
aiua-13516	109	17	including	include	VERB
aiua-13516	109	18	heterozygous	heterozygous	ADJ
aiua-13516	109	19	amplification	amplification	NOUN
aiua-13516	109	20	,	,	PUNCT
aiua-13516	109	21	heterozygous	heterozygous	ADJ
aiua-13516	109	22	deletion	deletion	NOUN
aiua-13516	109	23	,	,	PUNCT
aiua-13516	109	24	homozygous	homozygous	ADJ
aiua-13516	109	25	amplification	amplification	NOUN
aiua-13516	109	26	,	,	PUNCT
aiua-13516	109	27	and	and	CCONJ
aiua-13516	109	28	homozygous	homozygous	ADJ
aiua-13516	109	29	deletion	deletion	NOUN
aiua-13516	109	30	(	(	PUNCT
aiua-13516	109	31	supplementary	supplementary	ADJ
aiua-13516	109	32	figure	figure	NOUN
aiua-13516	109	33	s3b	s3b	ADV
aiua-13516	109	34	)	)	PUNCT
aiua-13516	109	35	.	.	PUNCT
aiua-13516	110	1	the	the	DET
aiua-13516	110	2	linear	linear	PROPN
aiua-13516	110	3	cnv	cnv	PROPN
aiua-13516	110	4	levels	level	NOUN
aiua-13516	110	5	of	of	ADP
aiua-13516	110	6	tcirg1	tcirg1	PROPN
aiua-13516	110	7	,	,	PUNCT
aiua-13516	110	8	tp53inp1	tp53inp1	PROPN
aiua-13516	110	9	,	,	PUNCT
aiua-13516	110	10	and	and	CCONJ
aiua-13516	110	11	tbx3	tbx3	PROPN
aiua-13516	110	12	were	be	AUX
aiua-13516	110	13	positively	positively	ADV
aiua-13516	110	14	correlated	correlate	VERB
aiua-13516	110	15	with	with	ADP
aiua-13516	110	16	their	their	PRON
aiua-13516	110	17	mrna	mrna	NOUN
aiua-13516	110	18	expression	expression	NOUN
aiua-13516	110	19	(	(	PUNCT
aiua-13516	110	20	supplementary	supplementary	ADJ
aiua-13516	110	21	figure	figure	NOUN
aiua-13516	110	22	s3c	s3c	PROPN
aiua-13516	110	23	)	)	PUNCT
aiua-13516	110	24	.	.	PUNCT
aiua-13516	111	1	the	the	DET
aiua-13516	111	2	expression	expression	NOUN
aiua-13516	111	3	of	of	ADP
aiua-13516	111	4	these	these	DET
aiua-13516	111	5	genes	gene	NOUN
aiua-13516	111	6	was	be	AUX
aiua-13516	111	7	generally	generally	ADV
aiua-13516	111	8	negatively	negatively	ADV
aiua-13516	111	9	correlated	correlate	VERB
aiua-13516	111	10	with	with	ADP
aiua-13516	111	11	their	their	PRON
aiua-13516	111	12	dna	dna	PROPN
aiua-13516	111	13	methylation	methylation	NOUN
aiua-13516	111	14	level	level	NOUN
aiua-13516	111	15	(	(	PUNCT
aiua-13516	111	16	supplementary	supplementary	ADJ
aiua-13516	111	17	figure	figure	NOUN
aiua-13516	111	18	s3d	s3d	PROPN
aiua-13516	111	19	)	)	PUNCT
aiua-13516	111	20	.	.	PUNCT
aiua-13516	112	1	the	the	DET
aiua-13516	112	2	association	association	PROPN
aiua-13516	112	3	of	of	ADP
aiua-13516	112	4	lactylation	lactylation	NOUN
aiua-13516	112	5	score	score	NOUN
aiua-13516	112	6	with	with	ADP
aiua-13516	112	7	clinical	clinical	ADJ
aiua-13516	112	8	features	feature	NOUN
aiua-13516	112	9	additionally	additionally	ADV
aiua-13516	112	10	,	,	PUNCT
aiua-13516	112	11	we	we	PRON
aiua-13516	112	12	discovered	discover	VERB
aiua-13516	112	13	that	that	SCONJ
aiua-13516	112	14	patients	patient	NOUN
aiua-13516	112	15	who	who	PRON
aiua-13516	112	16	are	be	AUX
aiua-13516	112	17	alive	alive	ADJ
aiua-13516	112	18	have	have	VERB
aiua-13516	112	19	lower	low	ADJ
aiua-13516	112	20	lactylation	lactylation	NOUN
aiua-13516	112	21	scores	score	NOUN
aiua-13516	112	22	compared	compare	VERB
aiua-13516	112	23	to	to	ADP
aiua-13516	112	24	those	those	PRON
aiua-13516	112	25	who	who	PRON
aiua-13516	112	26	have	have	AUX
aiua-13516	112	27	passed	pass	VERB
aiua-13516	112	28	away	away	ADP
aiua-13516	112	29	(	(	PUNCT
aiua-13516	112	30	figure	figure	VERB
aiua-13516	112	31	6a	6a	NOUN
aiua-13516	112	32	)	)	PUNCT
aiua-13516	112	33	.	.	PUNCT
aiua-13516	113	1	the	the	DET
aiua-13516	113	2	proportion	proportion	NOUN
aiua-13516	113	3	of	of	ADP
aiua-13516	113	4	patients	patient	NOUN
aiua-13516	113	5	who	who	PRON
aiua-13516	113	6	are	be	AUX
aiua-13516	113	7	alive	alive	ADJ
aiua-13516	113	8	in	in	ADP
aiua-13516	113	9	the	the	DET
aiua-13516	113	10	high	high	ADJ
aiua-13516	113	11	lactylation	lactylation	NOUN
aiua-13516	113	12	score	score	NOUN
aiua-13516	113	13	group	group	NOUN
aiua-13516	113	14	(	(	PUNCT
aiua-13516	113	15	43	43	NUM
aiua-13516	113	16	%	%	NOUN
aiua-13516	113	17	)	)	PUNCT
aiua-13516	113	18	was	be	AUX
aiua-13516	113	19	lower	low	ADJ
aiua-13516	113	20	than	than	ADP
aiua-13516	113	21	that	that	PRON
aiua-13516	113	22	in	in	ADP
aiua-13516	113	23	the	the	DET
aiua-13516	113	24	low	low	ADJ
aiua-13516	113	25	lactylation	lactylation	NOUN
aiua-13516	113	26	score	score	NOUN
aiua-13516	113	27	group	group	NOUN
aiua-13516	113	28	(	(	PUNCT
aiua-13516	113	29	63	63	NUM
aiua-13516	113	30	%	%	NOUN
aiua-13516	113	31	)	)	PUNCT
aiua-13516	113	32	.	.	PUNCT
aiua-13516	114	1	furthermore	furthermore	ADV
aiua-13516	114	2	,	,	PUNCT
aiua-13516	114	3	a	a	DET
aiua-13516	114	4	higher	high	ADJ
aiua-13516	114	5	lactylation	lactylation	NOUN
aiua-13516	114	6	score	score	NOUN
aiua-13516	114	7	was	be	AUX
aiua-13516	114	8	strongly	strongly	ADV
aiua-13516	114	9	associated	associate	VERB
aiua-13516	114	10	with	with	ADP
aiua-13516	114	11	other	other	ADJ
aiua-13516	114	12	clinical	clinical	ADJ
aiua-13516	114	13	features	feature	NOUN
aiua-13516	114	14	,	,	PUNCT
aiua-13516	114	15	including	include	VERB
aiua-13516	114	16	gender	gender	NOUN
aiua-13516	114	17	,	,	PUNCT
aiua-13516	114	18	grade	grade	NOUN
aiua-13516	114	19	,	,	PUNCT
aiua-13516	114	20	who	who	PRON
aiua-13516	114	21	stage	stage	VERB
aiua-13516	114	22	,	,	PUNCT
aiua-13516	114	23	n	n	PRON
aiua-13516	114	24	stage	stage	NOUN
aiua-13516	114	25	,	,	PUNCT
aiua-13516	114	26	and	and	CCONJ
aiua-13516	114	27	t	t	PROPN
aiua-13516	114	28	stage	stage	NOUN
aiua-13516	114	29	in	in	ADP
aiua-13516	114	30	blca	blca	PROPN
aiua-13516	114	31	(	(	PUNCT
aiua-13516	114	32	figure	figure	NOUN
aiua-13516	114	33	6b	6b	NOUN
aiua-13516	114	34	-	-	PUNCT
aiua-13516	114	35	f	f	NOUN
aiua-13516	114	36	)	)	PUNCT
aiua-13516	114	37	.	.	PUNCT
aiua-13516	115	1	the	the	DET
aiua-13516	115	2	correlation	correlation	NOUN
aiua-13516	115	3	of	of	ADP
aiua-13516	115	4	lactylation	lactylation	NOUN
aiua-13516	115	5	score	score	NOUN
aiua-13516	115	6	with	with	ADP
aiua-13516	115	7	immune	immune	ADJ
aiua-13516	115	8	microenvironment	microenvironment	NOUN
aiua-13516	115	9	and	and	CCONJ
aiua-13516	115	10	efficacy	efficacy	NOUN
aiua-13516	115	11	of	of	ADP
aiua-13516	115	12	immunotherapy	immunotherapy	NOUN
aiua-13516	115	13	the	the	DET
aiua-13516	115	14	correlation	correlation	NOUN
aiua-13516	115	15	between	between	ADP
aiua-13516	115	16	the	the	DET
aiua-13516	115	17	immune	immune	ADJ
aiua-13516	115	18	microenvironment	microenvironment	NOUN
aiua-13516	115	19	and	and	CCONJ
aiua-13516	115	20	lactylation	lactylation	NOUN
aiua-13516	115	21	score	score	NOUN
aiua-13516	115	22	was	be	AUX
aiua-13516	115	23	evaluated	evaluate	VERB
aiua-13516	115	24	.	.	PUNCT
aiua-13516	116	1	as	as	SCONJ
aiua-13516	116	2	illustrated	illustrate	VERB
aiua-13516	116	3	in	in	ADP
aiua-13516	116	4	figure	figure	NOUN
aiua-13516	116	5	7a	7a	NUM
aiua-13516	116	6	,	,	PUNCT
aiua-13516	116	7	chemokine	chemokine	ADJ
aiua-13516	116	8	and	and	CCONJ
aiua-13516	116	9	receptor	receptor	NOUN
aiua-13516	116	10	expression	expression	NOUN
aiua-13516	116	11	were	be	AUX
aiua-13516	116	12	notably	notably	ADV
aiua-13516	116	13	elevated	elevate	VERB
aiua-13516	116	14	in	in	ADP
aiua-13516	116	15	the	the	DET
aiua-13516	116	16	high	high	ADJ
aiua-13516	116	17	lactylation	lactylation	NOUN
aiua-13516	116	18	score	score	NOUN
aiua-13516	116	19	category	category	NOUN
aiua-13516	116	20	.	.	PUNCT
aiua-13516	117	1	the	the	DET
aiua-13516	117	2	lactylation	lactylation	NOUN
aiua-13516	117	3	score	score	NOUN
aiua-13516	117	4	exhibited	exhibit	VERB
aiua-13516	117	5	a	a	DET
aiua-13516	117	6	favorable	favorable	ADJ
aiua-13516	117	7	correlation	correlation	NOUN
aiua-13516	117	8	with	with	ADP
aiua-13516	117	9	immune	immune	NOUN
aiua-13516	117	10	-	-	PUNCT
aiua-13516	117	11	related	relate	VERB
aiua-13516	117	12	pathways	pathway	NOUN
aiua-13516	117	13	such	such	ADJ
aiua-13516	117	14	as	as	ADP
aiua-13516	117	15	inflammatory	inflammatory	ADJ
aiua-13516	117	16	response	response	NOUN
aiua-13516	117	17	,	,	PUNCT
aiua-13516	117	18	il6	il6	NOUN
aiua-13516	117	19	-	-	PUNCT
aiua-13516	117	20	jak	jak	NOUN
aiua-13516	117	21	-	-	PUNCT
aiua-13516	117	22	stat3	stat3	NOUN
aiua-13516	117	23	signaling	signal	VERB
aiua-13516	117	24	pathway	pathway	NOUN
aiua-13516	117	25	,	,	PUNCT
aiua-13516	117	26	il2	il2	NOUN
aiua-13516	117	27	-	-	PUNCT
aiua-13516	117	28	stat5	stat5	NOUN
aiua-13516	117	29	signaling	signal	VERB
aiua-13516	117	30	pathway	pathway	NOUN
aiua-13516	117	31	,	,	PUNCT
aiua-13516	117	32	and	and	CCONJ
aiua-13516	117	33	interferon	interferon	ADJ
aiua-13516	117	34	gamma	gamma	NOUN
aiua-13516	117	35	response	response	NOUN
aiua-13516	117	36	(	(	PUNCT
aiua-13516	117	37	figure	figure	NOUN
aiua-13516	117	38	7b	7b	NUM
aiua-13516	117	39	)	)	PUNCT
aiua-13516	117	40	.	.	PUNCT
aiua-13516	118	1	additionally	additionally	ADV
aiua-13516	118	2	,	,	PUNCT
aiua-13516	118	3	the	the	DET
aiua-13516	118	4	high	high	ADJ
aiua-13516	118	5	lactylation	lactylation	NOUN
aiua-13516	118	6	score	score	NOUN
aiua-13516	118	7	group	group	NOUN
aiua-13516	118	8	demonstrated	demonstrate	VERB
aiua-13516	118	9	an	an	DET
aiua-13516	118	10	elevated	elevated	ADJ
aiua-13516	118	11	immune	immune	ADJ
aiua-13516	118	12	checkpoint	checkpoint	NOUN
aiua-13516	118	13	expression	expression	NOUN
aiua-13516	118	14	,	,	PUNCT
aiua-13516	118	15	including	include	VERB
aiua-13516	118	16	figure	figure	NOUN
aiua-13516	118	17	6	6	NUM
aiua-13516	118	18	.	.	PUNCT
aiua-13516	119	1	the	the	DET
aiua-13516	119	2	association	association	NOUN
aiua-13516	119	3	of	of	ADP
aiua-13516	119	4	lactylation	lactylation	NOUN
aiua-13516	119	5	score	score	NOUN
aiua-13516	119	6	with	with	ADP
aiua-13516	119	7	clinical	clinical	ADJ
aiua-13516	119	8	features	feature	NOUN
aiua-13516	119	9	:	:	PUNCT
aiua-13516	119	10	a.	a.	NOUN
aiua-13516	119	11	left	leave	VERB
aiua-13516	119	12	:	:	PUNCT
aiua-13516	119	13	the	the	DET
aiua-13516	119	14	lactylation	lactylation	NOUN
aiua-13516	119	15	score	score	NOUN
aiua-13516	119	16	in	in	ADP
aiua-13516	119	17	alive	alive	ADJ
aiua-13516	119	18	and	and	CCONJ
aiua-13516	119	19	dead	dead	ADJ
aiua-13516	119	20	groups	group	NOUN
aiua-13516	119	21	.	.	PUNCT
aiua-13516	120	1	right	right	ADV
aiua-13516	120	2	:	:	PUNCT
aiua-13516	120	3	the	the	DET
aiua-13516	120	4	percentage	percentage	NOUN
aiua-13516	120	5	of	of	ADP
aiua-13516	120	6	alive	alive	ADJ
aiua-13516	120	7	and	and	CCONJ
aiua-13516	120	8	dead	dead	ADJ
aiua-13516	120	9	patients	patient	NOUN
aiua-13516	120	10	in	in	ADP
aiua-13516	120	11	high	high	ADJ
aiua-13516	120	12	and	and	CCONJ
aiua-13516	120	13	low	low	ADJ
aiua-13516	120	14	lactylation	lactylation	NOUN
aiua-13516	120	15	score	score	NOUN
aiua-13516	120	16	groups	group	NOUN
aiua-13516	120	17	.	.	PUNCT
aiua-13516	121	1	b.	b.	PROPN
aiua-13516	121	2	left	leave	VERB
aiua-13516	121	3	:	:	PUNCT
aiua-13516	121	4	the	the	DET
aiua-13516	121	5	lactylation	lactylation	NOUN
aiua-13516	121	6	score	score	NOUN
aiua-13516	121	7	in	in	ADP
aiua-13516	121	8	various	various	ADJ
aiua-13516	121	9	gender	gender	NOUN
aiua-13516	121	10	.	.	PUNCT
aiua-13516	122	1	right	right	ADJ
aiua-13516	122	2	:	:	PUNCT
aiua-13516	122	3	the	the	DET
aiua-13516	122	4	percentage	percentage	NOUN
aiua-13516	122	5	of	of	ADP
aiua-13516	122	6	various	various	ADJ
aiua-13516	122	7	gender	gender	NOUN
aiua-13516	122	8	patients	patient	NOUN
aiua-13516	122	9	in	in	ADP
aiua-13516	122	10	high	high	ADJ
aiua-13516	122	11	and	and	CCONJ
aiua-13516	122	12	low	low	ADJ
aiua-13516	122	13	lactylation	lactylation	NOUN
aiua-13516	122	14	score	score	NOUN
aiua-13516	122	15	groups	group	NOUN
aiua-13516	122	16	.	.	PUNCT
aiua-13516	123	1	c.	c.	PROPN
aiua-13516	123	2	left	leave	VERB
aiua-13516	123	3	:	:	PUNCT
aiua-13516	123	4	the	the	DET
aiua-13516	123	5	lactylation	lactylation	NOUN
aiua-13516	123	6	scores	score	NOUN
aiua-13516	123	7	in	in	ADP
aiua-13516	123	8	highand	highand	ADJ
aiua-13516	123	9	low	low	ADJ
aiua-13516	123	10	-	-	PUNCT
aiua-13516	123	11	grade	grade	NOUN
aiua-13516	123	12	groups	group	NOUN
aiua-13516	123	13	.	.	PUNCT
aiua-13516	124	1	right	right	ADV
aiua-13516	124	2	:	:	PUNCT
aiua-13516	124	3	the	the	DET
aiua-13516	124	4	percentages	percentage	NOUN
aiua-13516	124	5	of	of	ADP
aiua-13516	124	6	highand	highand	ADJ
aiua-13516	124	7	low	low	ADJ
aiua-13516	124	8	-	-	PUNCT
aiua-13516	124	9	grade	grade	NOUN
aiua-13516	124	10	patients	patient	NOUN
aiua-13516	124	11	in	in	ADP
aiua-13516	124	12	high	high	ADJ
aiua-13516	124	13	and	and	CCONJ
aiua-13516	124	14	low	low	ADJ
aiua-13516	124	15	lactylation	lactylation	NOUN
aiua-13516	124	16	score	score	NOUN
aiua-13516	124	17	groups	group	NOUN
aiua-13516	124	18	.	.	PUNCT
aiua-13516	125	1	d.	d.	PROPN
aiua-13516	125	2	left	leave	VERB
aiua-13516	125	3	:	:	PUNCT
aiua-13516	125	4	the	the	DET
aiua-13516	125	5	lactylation	lactylation	NOUN
aiua-13516	125	6	score	score	NOUN
aiua-13516	125	7	in	in	ADP
aiua-13516	125	8	highand	highand	ADJ
aiua-13516	125	9	low	low	ADJ
aiua-13516	125	10	-	-	PUNCT
aiua-13516	125	11	stage	stage	NOUN
aiua-13516	125	12	groups	group	NOUN
aiua-13516	125	13	.	.	PUNCT
aiua-13516	126	1	right	right	ADV
aiua-13516	126	2	:	:	PUNCT
aiua-13516	126	3	the	the	DET
aiua-13516	126	4	percentage	percentage	NOUN
aiua-13516	126	5	of	of	ADP
aiua-13516	126	6	high	high	ADJ
aiua-13516	126	7	and	and	CCONJ
aiua-13516	126	8	low	low	ADJ
aiua-13516	126	9	stage	stage	NOUN
aiua-13516	126	10	patients	patient	NOUN
aiua-13516	126	11	in	in	ADP
aiua-13516	126	12	high	high	ADJ
aiua-13516	126	13	and	and	CCONJ
aiua-13516	126	14	low	low	ADJ
aiua-13516	126	15	lactylation	lactylation	NOUN
aiua-13516	126	16	score	score	NOUN
aiua-13516	126	17	groups	group	NOUN
aiua-13516	126	18	.	.	PUNCT
aiua-13516	127	1	e.	e.	PROPN
aiua-13516	127	2	left	leave	VERB
aiua-13516	127	3	:	:	PUNCT
aiua-13516	127	4	the	the	DET
aiua-13516	127	5	lactylation	lactylation	NOUN
aiua-13516	127	6	score	score	NOUN
aiua-13516	127	7	in	in	ADP
aiua-13516	127	8	high	high	ADJ
aiua-13516	127	9	and	and	CCONJ
aiua-13516	127	10	low	low	ADJ
aiua-13516	127	11	n	n	NOUN
aiua-13516	127	12	stage	stage	NOUN
aiua-13516	127	13	groups	group	NOUN
aiua-13516	127	14	.	.	PUNCT
aiua-13516	128	1	right	right	ADV
aiua-13516	128	2	:	:	PUNCT
aiua-13516	128	3	the	the	DET
aiua-13516	128	4	percentage	percentage	NOUN
aiua-13516	128	5	of	of	ADP
aiua-13516	128	6	high	high	ADJ
aiua-13516	128	7	and	and	CCONJ
aiua-13516	128	8	low	low	ADJ
aiua-13516	128	9	n	n	NOUN
aiua-13516	128	10	stage	stage	NOUN
aiua-13516	128	11	patients	patient	NOUN
aiua-13516	128	12	in	in	ADP
aiua-13516	128	13	high	high	ADJ
aiua-13516	128	14	and	and	CCONJ
aiua-13516	128	15	low	low	ADJ
aiua-13516	128	16	lactylation	lactylation	NOUN
aiua-13516	128	17	score	score	NOUN
aiua-13516	128	18	groups	group	NOUN
aiua-13516	128	19	.	.	PUNCT
aiua-13516	129	1	f.	f.	PROPN
aiua-13516	129	2	left	leave	VERB
aiua-13516	129	3	:	:	PUNCT
aiua-13516	129	4	the	the	DET
aiua-13516	129	5	lactylation	lactylation	NOUN
aiua-13516	129	6	score	score	NOUN
aiua-13516	129	7	in	in	ADP
aiua-13516	129	8	high	high	ADJ
aiua-13516	129	9	and	and	CCONJ
aiua-13516	129	10	low	low	ADJ
aiua-13516	129	11	t	t	NOUN
aiua-13516	129	12	stage	stage	NOUN
aiua-13516	129	13	groups	group	NOUN
aiua-13516	129	14	.	.	PUNCT
aiua-13516	130	1	right	right	ADV
aiua-13516	130	2	:	:	PUNCT
aiua-13516	130	3	the	the	DET
aiua-13516	130	4	percentage	percentage	NOUN
aiua-13516	130	5	of	of	ADP
aiua-13516	130	6	high	high	ADJ
aiua-13516	130	7	and	and	CCONJ
aiua-13516	130	8	low	low	ADJ
aiua-13516	130	9	t	t	NOUN
aiua-13516	130	10	stage	stage	NOUN
aiua-13516	130	11	patients	patient	NOUN
aiua-13516	130	12	in	in	ADP
aiua-13516	130	13	high	high	ADJ
aiua-13516	130	14	and	and	CCONJ
aiua-13516	130	15	low	low	ADJ
aiua-13516	130	16	lactylation	lactylation	NOUN
aiua-13516	130	17	score	score	NOUN
aiua-13516	130	18	groups	group	NOUN
aiua-13516	130	19	.	.	PUNCT
aiua-13516	131	1	archivio	archivio	NOUN
aiua-13516	131	2	italiano	italiano	PROPN
aiua-13516	131	3	di	di	PROPN
aiua-13516	131	4	urologia	urologia	PROPN
aiua-13516	131	5	e	e	PROPN
aiua-13516	131	6	andrologia	andrologia	NOUN
aiua-13516	131	7	2025	2025	NUM
aiua-13516	131	8	;	;	PUNCT
aiua-13516	131	9	97(1):13516	97(1):13516	NUM
aiua-13516	131	10	9	9	NUM
aiua-13516	131	11	lactylation	lactylation	NOUN
aiua-13516	131	12	-	-	PUNCT
aiua-13516	131	13	related	relate	VERB
aiua-13516	131	14	gene	gene	NOUN
aiua-13516	131	15	signature	signature	NOUN
aiua-13516	131	16	in	in	ADP
aiua-13516	131	17	bladder	bladder	NOUN
aiua-13516	131	18	cancer	cancer	NOUN
aiua-13516	131	19	cd274	cd274	PROPN
aiua-13516	131	20	,	,	PUNCT
aiua-13516	131	21	ctla4	ctla4	NOUN
aiua-13516	131	22	,	,	PUNCT
aiua-13516	131	23	lag3	lag3	PROPN
aiua-13516	131	24	,	,	PUNCT
aiua-13516	131	25	pdcd1	pdcd1	NOUN
aiua-13516	131	26	,	,	PUNCT
aiua-13516	131	27	and	and	CCONJ
aiua-13516	131	28	tigit	tigit	NOUN
aiua-13516	131	29	(	(	PUNCT
aiua-13516	131	30	figure	figure	NOUN
aiua-13516	131	31	7c	7c	NUM
aiua-13516	131	32	)	)	PUNCT
aiua-13516	131	33	.	.	PUNCT
aiua-13516	132	1	moreover	moreover	ADV
aiua-13516	132	2	,	,	PUNCT
aiua-13516	132	3	the	the	DET
aiua-13516	132	4	high	high	ADJ
aiua-13516	132	5	lactylation	lactylation	NOUN
aiua-13516	132	6	score	score	NOUN
aiua-13516	132	7	group	group	NOUN
aiua-13516	132	8	presented	present	VERB
aiua-13516	132	9	a	a	DET
aiua-13516	132	10	higher	high	ADJ
aiua-13516	132	11	frequency	frequency	NOUN
aiua-13516	132	12	of	of	ADP
aiua-13516	132	13	gene	gene	NOUN
aiua-13516	132	14	mutations	mutation	NOUN
aiua-13516	132	15	(	(	PUNCT
aiua-13516	132	16	supplementary	supplementary	ADJ
aiua-13516	132	17	figure	figure	NOUN
aiua-13516	132	18	s4a	s4a	NOUN
aiua-13516	132	19	-	-	PUNCT
aiua-13516	132	20	c	c	NOUN
aiua-13516	132	21	)	)	PUNCT
aiua-13516	132	22	.	.	PUNCT
aiua-13516	133	1	these	these	DET
aiua-13516	133	2	findings	finding	NOUN
aiua-13516	133	3	further	far	ADV
aiua-13516	133	4	support	support	VERB
aiua-13516	133	5	the	the	DET
aiua-13516	133	6	theory	theory	NOUN
aiua-13516	133	7	that	that	SCONJ
aiua-13516	133	8	cancer	cancer	NOUN
aiua-13516	133	9	patients	patient	NOUN
aiua-13516	133	10	with	with	ADP
aiua-13516	133	11	a	a	DET
aiua-13516	133	12	high	high	ADJ
aiua-13516	133	13	lactylation	lactylation	NOUN
aiua-13516	133	14	score	score	NOUN
aiua-13516	133	15	may	may	AUX
aiua-13516	133	16	respond	respond	VERB
aiua-13516	133	17	well	well	ADV
aiua-13516	133	18	to	to	ADP
aiua-13516	133	19	immunotherapy	immunotherapy	NOUN
aiua-13516	133	20	.	.	PUNCT
aiua-13516	134	1	to	to	PART
aiua-13516	134	2	verify	verify	VERB
aiua-13516	134	3	our	our	PRON
aiua-13516	134	4	hypothesis	hypothesis	NOUN
aiua-13516	134	5	,	,	PUNCT
aiua-13516	134	6	further	further	ADJ
aiua-13516	134	7	analysis	analysis	NOUN
aiua-13516	134	8	was	be	AUX
aiua-13516	134	9	performed	perform	VERB
aiua-13516	134	10	using	use	VERB
aiua-13516	134	11	immunotherapy	immunotherapy	NOUN
aiua-13516	134	12	datasets	dataset	NOUN
aiua-13516	134	13	.	.	PUNCT
aiua-13516	135	1	we	we	PRON
aiua-13516	135	2	confirmed	confirm	VERB
aiua-13516	135	3	that	that	SCONJ
aiua-13516	135	4	patients	patient	NOUN
aiua-13516	135	5	with	with	ADP
aiua-13516	135	6	a	a	DET
aiua-13516	135	7	high	high	ADJ
aiua-13516	135	8	lactylation	lactylation	NOUN
aiua-13516	135	9	score	score	NOUN
aiua-13516	135	10	were	be	AUX
aiua-13516	135	11	responsive	responsive	ADJ
aiua-13516	135	12	to	to	ADP
aiua-13516	135	13	ici	ici	NOUN
aiua-13516	135	14	treatment	treatment	NOUN
aiua-13516	135	15	in	in	ADP
aiua-13516	135	16	the	the	DET
aiua-13516	135	17	imvigor210	imvigor210	PROPN
aiua-13516	135	18	cohort	cohort	NOUN
aiua-13516	135	19	(	(	PUNCT
aiua-13516	135	20	20	20	NUM
aiua-13516	135	21	)	)	PUNCT
aiua-13516	135	22	(	(	PUNCT
aiua-13516	135	23	figure	figure	NOUN
aiua-13516	135	24	7de	7de	NOUN
aiua-13516	135	25	;	;	PUNCT
aiua-13516	135	26	urothelial	urothelial	ADJ
aiua-13516	135	27	carcinoma	carcinoma	NOUN
aiua-13516	135	28	)	)	PUNCT
aiua-13516	135	29	and	and	CCONJ
aiua-13516	135	30	nct02684006	nct02684006	ADJ
aiua-13516	135	31	cohort	cohort	NOUN
aiua-13516	135	32	(	(	PUNCT
aiua-13516	135	33	21	21	NUM
aiua-13516	135	34	)	)	PUNCT
aiua-13516	135	35	(	(	PUNCT
aiua-13516	135	36	figure	figure	NOUN
aiua-13516	135	37	7f	7f	NOUN
aiua-13516	135	38	-	-	PUNCT
aiua-13516	135	39	g	g	NOUN
aiua-13516	135	40	;	;	PUNCT
aiua-13516	135	41	renal	renal	ADJ
aiua-13516	135	42	clear	clear	ADJ
aiua-13516	135	43	cell	cell	NOUN
aiua-13516	135	44	carcinoma	carcinoma	NOUN
aiua-13516	135	45	)	)	PUNCT
aiua-13516	135	46	.	.	PUNCT
aiua-13516	136	1	figure	figure	VERB
aiua-13516	136	2	7	7	NUM
aiua-13516	136	3	.	.	PUNCT
aiua-13516	137	1	the	the	DET
aiua-13516	137	2	correlation	correlation	NOUN
aiua-13516	137	3	of	of	ADP
aiua-13516	137	4	lactylation	lactylation	NOUN
aiua-13516	137	5	score	score	NOUN
aiua-13516	137	6	with	with	ADP
aiua-13516	137	7	immune	immune	ADJ
aiua-13516	137	8	microenvironment	microenvironment	NOUN
aiua-13516	137	9	and	and	CCONJ
aiua-13516	137	10	efficacy	efficacy	NOUN
aiua-13516	137	11	of	of	ADP
aiua-13516	137	12	immunotherapy	immunotherapy	NOUN
aiua-13516	137	13	:	:	PUNCT
aiua-13516	137	14	a.	a.	NOUN
aiua-13516	137	15	the	the	DET
aiua-13516	137	16	expression	expression	NOUN
aiua-13516	137	17	of	of	ADP
aiua-13516	137	18	chemokines	chemokine	NOUN
aiua-13516	137	19	and	and	CCONJ
aiua-13516	137	20	chemokine	chemokine	ADJ
aiua-13516	137	21	receptors	receptor	NOUN
aiua-13516	137	22	in	in	ADP
aiua-13516	137	23	high	high	ADJ
aiua-13516	137	24	and	and	CCONJ
aiua-13516	137	25	low	low	ADJ
aiua-13516	137	26	lactylation	lactylation	NOUN
aiua-13516	137	27	score	score	NOUN
aiua-13516	137	28	group	group	NOUN
aiua-13516	137	29	in	in	ADP
aiua-13516	137	30	blca	blca	PROPN
aiua-13516	137	31	.	.	PUNCT
aiua-13516	138	1	b.	b.	PROPN
aiua-13516	139	1	the	the	DET
aiua-13516	139	2	correlation	correlation	NOUN
aiua-13516	139	3	of	of	ADP
aiua-13516	139	4	lactylation	lactylation	NOUN
aiua-13516	139	5	score	score	NOUN
aiua-13516	139	6	with	with	ADP
aiua-13516	139	7	hallmark	hallmark	ADJ
aiua-13516	139	8	pathway	pathway	NOUN
aiua-13516	139	9	scores	score	NOUN
aiua-13516	139	10	.	.	PUNCT
aiua-13516	140	1	c.	c.	NOUN
aiua-13516	140	2	the	the	DET
aiua-13516	140	3	expression	expression	NOUN
aiua-13516	140	4	of	of	ADP
aiua-13516	140	5	immune	immune	ADJ
aiua-13516	140	6	checkpoints	checkpoint	NOUN
aiua-13516	140	7	in	in	ADP
aiua-13516	140	8	high	high	ADJ
aiua-13516	140	9	and	and	CCONJ
aiua-13516	140	10	low	low	ADJ
aiua-13516	140	11	lactylation	lactylation	NOUN
aiua-13516	140	12	score	score	NOUN
aiua-13516	140	13	group	group	NOUN
aiua-13516	140	14	.	.	PUNCT
aiua-13516	141	1	d.	d.	PROPN
aiua-13516	141	2	kaplan	kaplan	PROPN
aiua-13516	141	3	-	-	PROPN
aiua-13516	141	4	meier	meier	PROPN
aiua-13516	141	5	analysis	analysis	NOUN
aiua-13516	141	6	of	of	ADP
aiua-13516	141	7	patients	patient	NOUN
aiua-13516	141	8	in	in	ADP
aiua-13516	141	9	high	high	ADJ
aiua-13516	141	10	and	and	CCONJ
aiua-13516	141	11	low	low	ADJ
aiua-13516	141	12	lactylation	lactylation	NOUN
aiua-13516	141	13	score	score	NOUN
aiua-13516	141	14	groups	group	NOUN
aiua-13516	141	15	in	in	ADP
aiua-13516	141	16	imvigor210	imvigor210	PROPN
aiua-13516	141	17	cohort	cohort	NOUN
aiua-13516	141	18	.	.	PUNCT
aiua-13516	142	1	e.	e.	PROPN
aiua-13516	142	2	the	the	DET
aiua-13516	142	3	percentage	percentage	NOUN
aiua-13516	142	4	of	of	ADP
aiua-13516	142	5	patients	patient	NOUN
aiua-13516	142	6	with	with	ADP
aiua-13516	142	7	different	different	ADJ
aiua-13516	142	8	progress	progress	NOUN
aiua-13516	142	9	status	status	NOUN
aiua-13516	142	10	after	after	ADP
aiua-13516	142	11	ici	ici	PROPN
aiua-13516	142	12	treatment	treatment	NOUN
aiua-13516	142	13	in	in	ADP
aiua-13516	142	14	high	high	ADJ
aiua-13516	142	15	and	and	CCONJ
aiua-13516	142	16	low	low	ADJ
aiua-13516	142	17	lactylation	lactylation	NOUN
aiua-13516	142	18	score	score	NOUN
aiua-13516	142	19	groups	group	NOUN
aiua-13516	142	20	in	in	ADP
aiua-13516	142	21	imvigor210	imvigor210	PROPN
aiua-13516	142	22	cohort	cohort	NOUN
aiua-13516	142	23	.	.	PUNCT
aiua-13516	143	1	f.	f.	PROPN
aiua-13516	143	2	kaplan	kaplan	PROPN
aiua-13516	143	3	-	-	PROPN
aiua-13516	143	4	meier	meier	PROPN
aiua-13516	143	5	analysis	analysis	NOUN
aiua-13516	143	6	of	of	ADP
aiua-13516	143	7	patients	patient	NOUN
aiua-13516	143	8	in	in	ADP
aiua-13516	143	9	high	high	ADJ
aiua-13516	143	10	and	and	CCONJ
aiua-13516	143	11	low	low	ADJ
aiua-13516	143	12	lactylation	lactylation	NOUN
aiua-13516	143	13	score	score	NOUN
aiua-13516	143	14	groups	group	NOUN
aiua-13516	143	15	in	in	ADP
aiua-13516	143	16	nct02684006	nct02684006	ADJ
aiua-13516	143	17	cohort	cohort	NOUN
aiua-13516	143	18	.	.	PUNCT
aiua-13516	144	1	g.	g.	VERB
aiua-13516	144	2	the	the	DET
aiua-13516	144	3	percentage	percentage	NOUN
aiua-13516	144	4	of	of	ADP
aiua-13516	144	5	patients	patient	NOUN
aiua-13516	144	6	with	with	ADP
aiua-13516	144	7	different	different	ADJ
aiua-13516	144	8	progress	progress	NOUN
aiua-13516	144	9	status	status	NOUN
aiua-13516	144	10	after	after	ADP
aiua-13516	144	11	ici	ici	PROPN
aiua-13516	144	12	treatment	treatment	NOUN
aiua-13516	144	13	in	in	ADP
aiua-13516	144	14	high	high	ADJ
aiua-13516	144	15	and	and	CCONJ
aiua-13516	144	16	low	low	ADJ
aiua-13516	144	17	lactylation	lactylation	NOUN
aiua-13516	144	18	score	score	NOUN
aiua-13516	144	19	groups	group	NOUN
aiua-13516	144	20	in	in	ADP
aiua-13516	144	21	nct02684006	nct02684006	ADJ
aiua-13516	144	22	cohort	cohort	NOUN
aiua-13516	144	23	.	.	PUNCT
aiua-13516	145	1	archivio	archivio	NOUN
aiua-13516	145	2	italiano	italiano	PROPN
aiua-13516	145	3	di	di	PROPN
aiua-13516	145	4	urologia	urologia	PROPN
aiua-13516	145	5	e	e	PROPN
aiua-13516	145	6	andrologia	andrologia	NOUN
aiua-13516	145	7	2025	2025	NUM
aiua-13516	145	8	;	;	PUNCT
aiua-13516	145	9	97(1):13516	97(1):13516	NUM
aiua-13516	145	10	g.	g.	PROPN
aiua-13516	145	11	liu	liu	PROPN
aiua-13516	145	12	,	,	PUNCT
aiua-13516	145	13	t.	t.	PROPN
aiua-13516	145	14	hong	hong	PROPN
aiua-13516	145	15	,	,	PUNCT
aiua-13516	145	16	x.	x.	PROPN
aiua-13516	145	17	liu	liu	PROPN
aiua-13516	145	18	,	,	PUNCT
aiua-13516	145	19	et	et	PROPN
aiua-13516	145	20	al	al	PROPN
aiua-13516	145	21	.	.	PROPN
aiua-13516	146	1	10	10	NUM
aiua-13516	146	2	apart	apart	ADV
aiua-13516	146	3	from	from	ADP
aiua-13516	146	4	immunotherapy	immunotherapy	NOUN
aiua-13516	146	5	,	,	PUNCT
aiua-13516	146	6	we	we	PRON
aiua-13516	146	7	also	also	ADV
aiua-13516	146	8	analyzed	analyze	VERB
aiua-13516	146	9	other	other	ADJ
aiua-13516	146	10	antitumor	antitumor	PROPN
aiua-13516	146	11	drugs	drug	NOUN
aiua-13516	146	12	.	.	PUNCT
aiua-13516	147	1	based	base	VERB
aiua-13516	147	2	on	on	ADP
aiua-13516	147	3	the	the	DET
aiua-13516	147	4	predicted	predict	VERB
aiua-13516	147	5	results	result	NOUN
aiua-13516	147	6	using	use	VERB
aiua-13516	147	7	the	the	DET
aiua-13516	147	8	r	r	NOUN
aiua-13516	147	9	package	package	NOUN
aiua-13516	147	10	“	"	PUNCT
aiua-13516	147	11	prrophetic	prrophetic	ADJ
aiua-13516	147	12	”	"	PUNCT
aiua-13516	147	13	,	,	PUNCT
aiua-13516	147	14	we	we	PRON
aiua-13516	147	15	displayed	display	VERB
aiua-13516	147	16	6	6	NUM
aiua-13516	147	17	commonly	commonly	ADV
aiua-13516	147	18	used	use	VERB
aiua-13516	147	19	chemotherapeutic	chemotherapeutic	ADJ
aiua-13516	147	20	agents	agent	NOUN
aiua-13516	147	21	for	for	ADP
aiua-13516	147	22	blca	blca	PROPN
aiua-13516	147	23	,	,	PUNCT
aiua-13516	147	24	including	include	VERB
aiua-13516	147	25	gemcitabine	gemcitabine	NOUN
aiua-13516	147	26	,	,	PUNCT
aiua-13516	147	27	cisplatin	cisplatin	NOUN
aiua-13516	147	28	,	,	PUNCT
aiua-13516	147	29	vinblastine	vinblastine	NOUN
aiua-13516	147	30	,	,	PUNCT
aiua-13516	147	31	doxorubicin	doxorubicin	PROPN
aiua-13516	147	32	,	,	PUNCT
aiua-13516	147	33	docetaxel	docetaxel	NOUN
aiua-13516	147	34	,	,	PUNCT
aiua-13516	147	35	and	and	CCONJ
aiua-13516	147	36	paclitaxel	paclitaxel	PROPN
aiua-13516	147	37	,	,	PUNCT
aiua-13516	147	38	may	may	AUX
aiua-13516	147	39	be	be	AUX
aiua-13516	147	40	resistant	resistant	ADJ
aiua-13516	147	41	to	to	ADP
aiua-13516	147	42	patients	patient	NOUN
aiua-13516	147	43	with	with	ADP
aiua-13516	147	44	a	a	DET
aiua-13516	147	45	high	high	ADJ
aiua-13516	147	46	lactylation	lactylation	NOUN
aiua-13516	147	47	score	score	NOUN
aiua-13516	147	48	.	.	PUNCT
aiua-13516	148	1	furthermore	furthermore	ADV
aiua-13516	148	2	,	,	PUNCT
aiua-13516	148	3	5	5	NUM
aiua-13516	148	4	targeted	target	VERB
aiua-13516	148	5	agents	agent	NOUN
aiua-13516	148	6	,	,	PUNCT
aiua-13516	148	7	including	include	VERB
aiua-13516	148	8	sunitinib	sunitinib	NOUN
aiua-13516	148	9	,	,	PUNCT
aiua-13516	148	10	pazopanib	pazopanib	NOUN
aiua-13516	148	11	,	,	PUNCT
aiua-13516	148	12	gefitinib	gefitinib	NOUN
aiua-13516	148	13	,	,	PUNCT
aiua-13516	148	14	erlotinib	erlotinib	NOUN
aiua-13516	148	15	,	,	PUNCT
aiua-13516	148	16	and	and	CCONJ
aiua-13516	148	17	tipifarnib	tipifarnib	NOUN
aiua-13516	148	18	,	,	PUNCT
aiua-13516	148	19	were	be	AUX
aiua-13516	148	20	also	also	ADV
aiua-13516	148	21	revealed	reveal	VERB
aiua-13516	148	22	to	to	PART
aiua-13516	148	23	be	be	AUX
aiua-13516	148	24	resistance	resistance	NOUN
aiua-13516	148	25	in	in	ADP
aiua-13516	148	26	high	high	ADJ
aiua-13516	148	27	lactylation	lactylation	NOUN
aiua-13516	148	28	score	score	NOUN
aiua-13516	148	29	group	group	NOUN
aiua-13516	148	30	(	(	PUNCT
aiua-13516	148	31	supplementary	supplementary	ADJ
aiua-13516	148	32	figure	figure	NOUN
aiua-13516	148	33	s5	s5	PROPN
aiua-13516	148	34	)	)	PUNCT
aiua-13516	148	35	.	.	PUNCT
aiua-13516	149	1	discussion	discussion	NOUN
aiua-13516	149	2	lactylation	lactylation	PROPN
aiua-13516	149	3	modification	modification	NOUN
aiua-13516	149	4	seems	seem	VERB
aiua-13516	149	5	to	to	PART
aiua-13516	149	6	have	have	VERB
aiua-13516	149	7	an	an	DET
aiua-13516	149	8	important	important	ADJ
aiua-13516	149	9	place	place	NOUN
aiua-13516	149	10	in	in	ADP
aiua-13516	149	11	cancer	cancer	NOUN
aiua-13516	149	12	therapeutics	therapeutic	NOUN
aiua-13516	149	13	research	research	NOUN
aiua-13516	149	14	.	.	PUNCT
aiua-13516	150	1	it	it	PRON
aiua-13516	150	2	has	have	AUX
aiua-13516	150	3	been	be	AUX
aiua-13516	150	4	well	well	ADV
aiua-13516	150	5	shown	show	VERB
aiua-13516	150	6	that	that	SCONJ
aiua-13516	150	7	tumor	tumor	NOUN
aiua-13516	150	8	cells	cell	NOUN
aiua-13516	150	9	undergo	undergo	VERB
aiua-13516	150	10	metabolic	metabolic	NOUN
aiua-13516	150	11	reprogramming	reprogramming	NOUN
aiua-13516	150	12	,	,	PUNCT
aiua-13516	150	13	resulting	result	VERB
aiua-13516	150	14	in	in	ADP
aiua-13516	150	15	increased	increase	VERB
aiua-13516	150	16	lactate	lactate	NOUN
aiua-13516	150	17	production	production	NOUN
aiua-13516	150	18	and	and	CCONJ
aiua-13516	150	19	alterations	alteration	NOUN
aiua-13516	150	20	in	in	ADP
aiua-13516	150	21	the	the	DET
aiua-13516	150	22	microenvironment	microenvironment	NOUN
aiua-13516	150	23	(	(	PUNCT
aiua-13516	150	24	22	22	NUM
aiua-13516	150	25	-	-	SYM
aiua-13516	150	26	24	24	NUM
aiua-13516	150	27	)	)	PUNCT
aiua-13516	150	28	.	.	PUNCT
aiua-13516	151	1	related	relate	VERB
aiua-13516	151	2	with	with	ADP
aiua-13516	151	3	this	this	DET
aiua-13516	151	4	issue	issue	NOUN
aiua-13516	151	5	,	,	PUNCT
aiua-13516	151	6	lactate	lactate	PROPN
aiua-13516	151	7	has	have	AUX
aiua-13516	151	8	been	be	AUX
aiua-13516	151	9	shown	show	VERB
aiua-13516	151	10	to	to	PART
aiua-13516	151	11	play	play	VERB
aiua-13516	151	12	a	a	DET
aiua-13516	151	13	critical	critical	ADJ
aiua-13516	151	14	role	role	NOUN
aiua-13516	151	15	in	in	ADP
aiua-13516	151	16	tumor	tumor	NOUN
aiua-13516	151	17	growth	growth	NOUN
aiua-13516	151	18	and	and	CCONJ
aiua-13516	151	19	progression	progression	NOUN
aiua-13516	151	20	by	by	ADP
aiua-13516	151	21	promoting	promote	VERB
aiua-13516	151	22	angiogenesis	angiogenesis	NOUN
aiua-13516	151	23	,	,	PUNCT
aiua-13516	151	24	immune	immune	ADJ
aiua-13516	151	25	evasion	evasion	NOUN
aiua-13516	151	26	,	,	PUNCT
aiua-13516	151	27	and	and	CCONJ
aiua-13516	151	28	metastasis	metastasis	NOUN
aiua-13516	151	29	(	(	PUNCT
aiua-13516	151	30	25	25	NUM
aiua-13516	151	31	)	)	PUNCT
aiua-13516	151	32	.	.	PUNCT
aiua-13516	152	1	moreover	moreover	ADV
aiua-13516	152	2	,	,	PUNCT
aiua-13516	152	3	lactylation	lactylation	NOUN
aiua-13516	152	4	of	of	ADP
aiua-13516	152	5	proteins	protein	NOUN
aiua-13516	152	6	has	have	AUX
aiua-13516	152	7	been	be	AUX
aiua-13516	152	8	found	find	VERB
aiua-13516	152	9	to	to	PART
aiua-13516	152	10	modulate	modulate	VERB
aiua-13516	152	11	cellular	cellular	ADJ
aiua-13516	152	12	processes	process	NOUN
aiua-13516	152	13	involved	involve	VERB
aiua-13516	152	14	in	in	ADP
aiua-13516	152	15	carcinogenesis	carcinogenesis	NOUN
aiua-13516	152	16	regarding	regard	VERB
aiua-13516	152	17	the	the	DET
aiua-13516	152	18	survival	survival	NOUN
aiua-13516	152	19	,	,	PUNCT
aiua-13516	152	20	proliferation	proliferation	NOUN
aiua-13516	152	21	,	,	PUNCT
aiua-13516	152	22	and	and	CCONJ
aiua-13516	152	23	invasion	invasion	NOUN
aiua-13516	152	24	status	status	NOUN
aiua-13516	152	25	(	(	PUNCT
aiua-13516	152	26	26	26	NUM
aiua-13516	152	27	,	,	PUNCT
aiua-13516	152	28	27	27	NUM
aiua-13516	152	29	)	)	PUNCT
aiua-13516	152	30	.	.	PUNCT
aiua-13516	153	1	these	these	DET
aiua-13516	153	2	findings	finding	NOUN
aiua-13516	153	3	suggest	suggest	VERB
aiua-13516	153	4	that	that	SCONJ
aiua-13516	153	5	lactylation	lactylation	ADJ
aiua-13516	153	6	modification	modification	NOUN
aiua-13516	153	7	may	may	AUX
aiua-13516	153	8	offer	offer	VERB
aiua-13516	153	9	novel	novel	ADJ
aiua-13516	153	10	therapeutic	therapeutic	ADJ
aiua-13516	153	11	targets	target	NOUN
aiua-13516	153	12	in	in	ADP
aiua-13516	153	13	the	the	DET
aiua-13516	153	14	management	management	NOUN
aiua-13516	153	15	of	of	ADP
aiua-13516	153	16	cancer	cancer	NOUN
aiua-13516	153	17	.	.	PUNCT
aiua-13516	154	1	however	however	ADV
aiua-13516	154	2	,	,	PUNCT
aiua-13516	154	3	further	further	ADJ
aiua-13516	154	4	studies	study	NOUN
aiua-13516	154	5	are	be	AUX
aiua-13516	154	6	needed	need	VERB
aiua-13516	154	7	to	to	PART
aiua-13516	154	8	identify	identify	VERB
aiua-13516	154	9	specific	specific	ADJ
aiua-13516	154	10	lactylated	lactylate	VERB
aiua-13516	154	11	targets	target	NOUN
aiua-13516	154	12	and	and	CCONJ
aiua-13516	154	13	explore	explore	VERB
aiua-13516	154	14	the	the	DET
aiua-13516	154	15	possible	possible	ADJ
aiua-13516	154	16	underlying	underlying	ADJ
aiua-13516	154	17	mechanisms	mechanism	NOUN
aiua-13516	154	18	of	of	ADP
aiua-13516	154	19	this	this	DET
aiua-13516	154	20	process	process	NOUN
aiua-13516	154	21	in	in	ADP
aiua-13516	154	22	different	different	ADJ
aiua-13516	154	23	types	type	NOUN
aiua-13516	154	24	of	of	ADP
aiua-13516	154	25	tumors	tumor	NOUN
aiua-13516	154	26	.	.	PUNCT
aiua-13516	155	1	in	in	ADP
aiua-13516	155	2	recent	recent	ADJ
aiua-13516	155	3	years	year	NOUN
aiua-13516	155	4	,	,	PUNCT
aiua-13516	155	5	increasing	increase	VERB
aiua-13516	155	6	attention	attention	NOUN
aiua-13516	155	7	has	have	AUX
aiua-13516	155	8	been	be	AUX
aiua-13516	155	9	focused	focus	VERB
aiua-13516	155	10	on	on	ADP
aiua-13516	155	11	the	the	DET
aiua-13516	155	12	possible	possible	ADJ
aiua-13516	155	13	role	role	NOUN
aiua-13516	155	14	of	of	ADP
aiua-13516	155	15	lactylation	lactylation	NOUN
aiua-13516	155	16	modification	modification	NOUN
aiua-13516	155	17	in	in	ADP
aiua-13516	155	18	carcinogenesis	carcinogenesis	NOUN
aiua-13516	155	19	of	of	ADP
aiua-13516	155	20	different	different	ADJ
aiua-13516	155	21	tumor	tumor	NOUN
aiua-13516	155	22	types	type	NOUN
aiua-13516	155	23	such	such	ADJ
aiua-13516	155	24	as	as	ADP
aiua-13516	155	25	bladder	bladder	NOUN
aiua-13516	155	26	cancer	cancer	NOUN
aiua-13516	155	27	(	(	PUNCT
aiua-13516	155	28	28	28	NUM
aiua-13516	155	29	)	)	PUNCT
aiua-13516	155	30	,	,	PUNCT
aiua-13516	155	31	lung	lung	NOUN
aiua-13516	155	32	cancer	cancer	NOUN
aiua-13516	155	33	(	(	PUNCT
aiua-13516	155	34	29	29	NUM
aiua-13516	155	35	)	)	PUNCT
aiua-13516	155	36	,	,	PUNCT
aiua-13516	155	37	liver	liver	NOUN
aiua-13516	155	38	cancer	cancer	NOUN
aiua-13516	155	39	(	(	PUNCT
aiua-13516	155	40	27	27	NUM
aiua-13516	155	41	,	,	PUNCT
aiua-13516	155	42	30	30	NUM
aiua-13516	155	43	)	)	PUNCT
aiua-13516	155	44	,	,	PUNCT
aiua-13516	155	45	and	and	CCONJ
aiua-13516	155	46	gastric	gastric	ADJ
aiua-13516	155	47	cancer	cancer	NOUN
aiua-13516	155	48	(	(	PUNCT
aiua-13516	155	49	31	31	NUM
aiua-13516	155	50	)	)	PUNCT
aiua-13516	155	51	.	.	PUNCT
aiua-13516	156	1	a	a	DET
aiua-13516	156	2	recent	recent	ADJ
aiua-13516	156	3	study	study	NOUN
aiua-13516	156	4	indentified	indentifie	VERB
aiua-13516	156	5	a	a	DET
aiua-13516	156	6	unique	unique	ADJ
aiua-13516	156	7	cluster	cluster	NOUN
aiua-13516	156	8	of	of	ADP
aiua-13516	156	9	cisplatin	cisplatin	NOUN
aiua-13516	156	10	-	-	PUNCT
aiua-13516	156	11	resistant	resistant	ADJ
aiua-13516	156	12	epithelial	epithelial	ADJ
aiua-13516	156	13	cells	cell	NOUN
aiua-13516	156	14	by	by	ADP
aiua-13516	156	15	constructing	construct	VERB
aiua-13516	156	16	a	a	DET
aiua-13516	156	17	blca	blca	ADJ
aiua-13516	156	18	single	single	ADJ
aiua-13516	156	19	-	-	PUNCT
aiua-13516	156	20	cell	cell	NOUN
aiua-13516	156	21	atlas	atlas	PROPN
aiua-13516	156	22	.	.	PUNCT
aiua-13516	157	1	the	the	DET
aiua-13516	157	2	elevated	elevated	ADJ
aiua-13516	157	3	lactylation	lactylation	NOUN
aiua-13516	157	4	was	be	AUX
aiua-13516	157	5	founded	found	VERB
aiua-13516	157	6	in	in	ADP
aiua-13516	157	7	the	the	DET
aiua-13516	157	8	cisplatin	cisplatin	NOUN
aiua-13516	157	9	-	-	PUNCT
aiua-13516	157	10	resistant	resistant	ADJ
aiua-13516	157	11	cluster	cluster	NOUN
aiua-13516	157	12	and	and	CCONJ
aiua-13516	157	13	verified	verify	VERB
aiua-13516	157	14	in	in	ADP
aiua-13516	157	15	blca	blca	ADJ
aiua-13516	157	16	cell	cell	NOUN
aiua-13516	157	17	lines	line	NOUN
aiua-13516	157	18	with	with	ADP
aiua-13516	157	19	cisplatin	cisplatin	NOUN
aiua-13516	157	20	resistance	resistance	NOUN
aiua-13516	157	21	.	.	PUNCT
aiua-13516	158	1	furthermore	furthermore	ADV
aiua-13516	158	2	,	,	PUNCT
aiua-13516	158	3	h3k18la	h3k18la	PROPN
aiua-13516	158	4	was	be	AUX
aiua-13516	158	5	up	up	ADV
aiua-13516	158	6	-	-	PUNCT
aiua-13516	158	7	regulated	regulate	VERB
aiua-13516	158	8	in	in	ADP
aiua-13516	158	9	cisplatin	cisplatin	NOUN
aiua-13516	158	10	-	-	PUNCT
aiua-13516	158	11	resistant	resistant	ADJ
aiua-13516	158	12	blca	blca	ADJ
aiua-13516	158	13	cell	cell	NOUN
aiua-13516	158	14	lines	line	NOUN
aiua-13516	158	15	,	,	PUNCT
aiua-13516	158	16	and	and	CCONJ
aiua-13516	158	17	heightened	heighten	VERB
aiua-13516	158	18	transcription	transcription	NOUN
aiua-13516	158	19	factor	factor	NOUN
aiua-13516	158	20	expression	expression	NOUN
aiua-13516	158	21	such	such	ADJ
aiua-13516	158	22	as	as	ADP
aiua-13516	158	23	ybx1	ybx1	NOUN
aiua-13516	158	24	and	and	CCONJ
aiua-13516	158	25	yy1	yy1	NOUN
aiua-13516	158	26	,	,	PUNCT
aiua-13516	158	27	ultimately	ultimately	ADV
aiua-13516	158	28	driving	drive	VERB
aiua-13516	158	29	cisplatin	cisplatin	NOUN
aiua-13516	158	30	resistance	resistance	NOUN
aiua-13516	158	31	in	in	ADP
aiua-13516	158	32	blca	blca	PROPN
aiua-13516	158	33	(	(	PUNCT
aiua-13516	158	34	28	28	NUM
aiua-13516	158	35	)	)	PUNCT
aiua-13516	158	36	.	.	PUNCT
aiua-13516	159	1	more	more	ADJ
aiua-13516	159	2	and	and	CCONJ
aiua-13516	159	3	more	more	ADJ
aiua-13516	159	4	studies	study	NOUN
aiua-13516	159	5	demonstrated	demonstrate	VERB
aiua-13516	159	6	the	the	DET
aiua-13516	159	7	emerging	emerge	VERB
aiua-13516	159	8	evidence	evidence	NOUN
aiua-13516	159	9	suggesting	suggest	VERB
aiua-13516	159	10	that	that	SCONJ
aiua-13516	159	11	lactylation	lactylation	PROPN
aiua-13516	159	12	modification	modification	NOUN
aiua-13516	159	13	plays	play	VERB
aiua-13516	159	14	a	a	DET
aiua-13516	159	15	critical	critical	ADJ
aiua-13516	159	16	role	role	NOUN
aiua-13516	159	17	in	in	ADP
aiua-13516	159	18	the	the	DET
aiua-13516	159	19	pathogenesis	pathogenesis	NOUN
aiua-13516	159	20	and	and	CCONJ
aiua-13516	159	21	progression	progression	NOUN
aiua-13516	159	22	of	of	ADP
aiua-13516	159	23	cancer	cancer	NOUN
aiua-13516	159	24	.	.	PUNCT
aiua-13516	160	1	however	however	ADV
aiua-13516	160	2	,	,	PUNCT
aiua-13516	160	3	further	further	ADJ
aiua-13516	160	4	research	research	NOUN
aiua-13516	160	5	is	be	AUX
aiua-13516	160	6	certainly	certainly	ADV
aiua-13516	160	7	needed	need	VERB
aiua-13516	160	8	to	to	PART
aiua-13516	160	9	explore	explore	VERB
aiua-13516	160	10	the	the	DET
aiua-13516	160	11	exact	exact	ADJ
aiua-13516	160	12	underlying	underlying	ADJ
aiua-13516	160	13	mechanisms	mechanism	NOUN
aiua-13516	160	14	of	of	ADP
aiua-13516	160	15	lactylation	lactylation	NOUN
aiua-13516	160	16	in	in	ADP
aiua-13516	160	17	different	different	ADJ
aiua-13516	160	18	types	type	NOUN
aiua-13516	160	19	of	of	ADP
aiua-13516	160	20	tumors	tumor	NOUN
aiua-13516	160	21	and	and	CCONJ
aiua-13516	160	22	to	to	PART
aiua-13516	160	23	develop	develop	VERB
aiua-13516	160	24	novel	novel	ADJ
aiua-13516	160	25	lactylation	lactylation	NOUN
aiua-13516	160	26	-	-	PUNCT
aiua-13516	160	27	based	base	VERB
aiua-13516	160	28	therapies	therapy	NOUN
aiua-13516	160	29	for	for	ADP
aiua-13516	160	30	the	the	DET
aiua-13516	160	31	treatment	treatment	NOUN
aiua-13516	160	32	of	of	ADP
aiua-13516	160	33	cancer	cancer	NOUN
aiua-13516	160	34	.	.	PUNCT
aiua-13516	161	1	in	in	ADP
aiua-13516	161	2	this	this	DET
aiua-13516	161	3	study	study	NOUN
aiua-13516	161	4	,	,	PUNCT
aiua-13516	161	5	firstly	firstly	ADV
aiua-13516	161	6	we	we	PRON
aiua-13516	161	7	evaluated	evaluate	VERB
aiua-13516	161	8	11different	11different	NUM
aiua-13516	161	9	lactylation	lactylation	NOUN
aiua-13516	161	10	genes	gene	NOUN
aiua-13516	161	11	.	.	PUNCT
aiua-13516	162	1	by	by	ADP
aiua-13516	162	2	examining	examine	VERB
aiua-13516	162	3	the	the	DET
aiua-13516	162	4	expression	expression	NOUN
aiua-13516	162	5	of	of	ADP
aiua-13516	162	6	these	these	DET
aiua-13516	162	7	lactylation	lactylation	NOUN
aiua-13516	162	8	genes	gene	NOUN
aiua-13516	162	9	,	,	PUNCT
aiua-13516	162	10	we	we	PRON
aiua-13516	162	11	identified	identify	VERB
aiua-13516	162	12	two	two	NUM
aiua-13516	162	13	subtypes	subtype	NOUN
aiua-13516	162	14	of	of	ADP
aiua-13516	162	15	blca	blca	NOUN
aiua-13516	162	16	(	(	PUNCT
aiua-13516	162	17	cluster	cluster	NOUN
aiua-13516	162	18	a	a	PRON
aiua-13516	162	19	and	and	CCONJ
aiua-13516	162	20	b	b	NOUN
aiua-13516	162	21	)	)	PUNCT
aiua-13516	162	22	.	.	PUNCT
aiua-13516	163	1	additionally	additionally	ADV
aiua-13516	163	2	,	,	PUNCT
aiua-13516	163	3	we	we	PRON
aiua-13516	163	4	observed	observe	VERB
aiua-13516	163	5	the	the	DET
aiua-13516	163	6	difference	difference	NOUN
aiua-13516	163	7	in	in	ADP
aiua-13516	163	8	malignant	malignant	ADJ
aiua-13516	163	9	cancer	cancer	NOUN
aiua-13516	163	10	-	-	PUNCT
aiua-13516	163	11	promoting	promote	VERB
aiua-13516	163	12	pathways	pathway	NOUN
aiua-13516	163	13	and	and	CCONJ
aiua-13516	163	14	immune	immune	NOUN
aiua-13516	163	15	-	-	PUNCT
aiua-13516	163	16	related	relate	VERB
aiua-13516	163	17	pathways	pathway	NOUN
aiua-13516	163	18	between	between	ADP
aiua-13516	163	19	cluster	cluster	NOUN
aiua-13516	163	20	a	a	PRON
aiua-13516	163	21	and	and	CCONJ
aiua-13516	163	22	b	b	NOUN
aiua-13516	163	23	,	,	PUNCT
aiua-13516	163	24	such	such	ADJ
aiua-13516	163	25	as	as	ADP
aiua-13516	163	26	tgf	tgf	PROPN
aiua-13516	163	27	beta	beta	NOUN
aiua-13516	163	28	signaling	signal	VERB
aiua-13516	163	29	,	,	PUNCT
aiua-13516	163	30	mtorc1	mtorc1	NOUN
aiua-13516	163	31	signaling	signal	VERB
aiua-13516	163	32	,	,	PUNCT
aiua-13516	163	33	and	and	CCONJ
aiua-13516	163	34	wnt	wnt	NOUN
aiua-13516	163	35	signaling	signal	VERB
aiua-13516	163	36	pathway	pathway	NOUN
aiua-13516	163	37	.	.	PUNCT
aiua-13516	164	1	based	base	VERB
aiua-13516	164	2	on	on	ADP
aiua-13516	164	3	these	these	DET
aiua-13516	164	4	findings	finding	NOUN
aiua-13516	164	5	,	,	PUNCT
aiua-13516	164	6	in	in	ADP
aiua-13516	164	7	the	the	DET
aiua-13516	164	8	second	second	ADJ
aiua-13516	164	9	stage	stage	NOUN
aiua-13516	164	10	we	we	PRON
aiua-13516	164	11	investigated	investigate	VERB
aiua-13516	164	12	the	the	DET
aiua-13516	164	13	immune	immune	ADJ
aiua-13516	164	14	infiltration	infiltration	NOUN
aiua-13516	164	15	in	in	ADP
aiua-13516	164	16	blca	blca	ADJ
aiua-13516	164	17	samples	sample	NOUN
aiua-13516	164	18	.	.	PUNCT
aiua-13516	165	1	the	the	DET
aiua-13516	165	2	stromal	stromal	ADJ
aiua-13516	165	3	,	,	PUNCT
aiua-13516	165	4	immune	immune	ADJ
aiua-13516	165	5	,	,	PUNCT
aiua-13516	165	6	and	and	CCONJ
aiua-13516	165	7	estimate	estimate	VERB
aiua-13516	165	8	scores	score	NOUN
aiua-13516	165	9	were	be	AUX
aiua-13516	165	10	all	all	ADV
aiua-13516	165	11	higher	high	ADJ
aiua-13516	165	12	in	in	ADP
aiua-13516	165	13	cluster	cluster	NOUN
aiua-13516	165	14	a	a	NOUN
aiua-13516	165	15	,	,	PUNCT
aiua-13516	165	16	and	and	CCONJ
aiua-13516	165	17	most	most	ADJ
aiua-13516	165	18	immune	immune	ADJ
aiua-13516	165	19	cell	cell	NOUN
aiua-13516	165	20	levels	level	NOUN
aiua-13516	165	21	were	be	AUX
aiua-13516	165	22	found	find	VERB
aiua-13516	165	23	to	to	PART
aiua-13516	165	24	be	be	AUX
aiua-13516	165	25	highly	highly	ADV
aiua-13516	165	26	infiltrated	infiltrate	VERB
aiua-13516	165	27	in	in	ADP
aiua-13516	165	28	cluster	cluster	NOUN
aiua-13516	165	29	a	a	PRON
aiua-13516	165	30	than	than	ADP
aiua-13516	165	31	in	in	ADP
aiua-13516	165	32	cluster	cluster	NOUN
aiua-13516	165	33	b.	b.	PROPN
aiua-13516	165	34	based	base	VERB
aiua-13516	165	35	on	on	ADP
aiua-13516	165	36	this	this	DET
aiua-13516	165	37	information	information	NOUN
aiua-13516	165	38	in	in	ADP
aiua-13516	165	39	our	our	PRON
aiua-13516	165	40	study	study	NOUN
aiua-13516	165	41	we	we	PRON
aiua-13516	165	42	aimed	aim	VERB
aiua-13516	165	43	to	to	PART
aiua-13516	165	44	develop	develop	VERB
aiua-13516	165	45	a	a	DET
aiua-13516	165	46	lactylation	lactylation	NOUN
aiua-13516	165	47	score	score	NOUN
aiua-13516	165	48	for	for	ADP
aiua-13516	165	49	quantifying	quantify	VERB
aiua-13516	165	50	patient	patient	ADJ
aiua-13516	165	51	risk	risk	NOUN
aiua-13516	165	52	.	.	PUNCT
aiua-13516	166	1	initially	initially	ADV
aiua-13516	166	2	,	,	PUNCT
aiua-13516	166	3	we	we	PRON
aiua-13516	166	4	screened	screen	VERB
aiua-13516	166	5	275	275	NUM
aiua-13516	166	6	degs	deg	NOUN
aiua-13516	166	7	across	across	ADP
aiua-13516	166	8	two	two	NUM
aiua-13516	166	9	clusters	cluster	NOUN
aiua-13516	166	10	and	and	CCONJ
aiua-13516	166	11	later	later	ADV
aiua-13516	166	12	we	we	PRON
aiua-13516	166	13	conducted	conduct	VERB
aiua-13516	166	14	univariate	univariate	ADJ
aiua-13516	166	15	cox	cox	PROPN
aiua-13516	166	16	regression	regression	NOUN
aiua-13516	166	17	analysis	analysis	NOUN
aiua-13516	166	18	to	to	PART
aiua-13516	166	19	determine	determine	VERB
aiua-13516	166	20	the	the	DET
aiua-13516	166	21	prognostic	prognostic	ADJ
aiua-13516	166	22	value	value	NOUN
aiua-13516	166	23	of	of	ADP
aiua-13516	166	24	these	these	DET
aiua-13516	166	25	275	275	NUM
aiua-13516	166	26	degs	deg	NOUN
aiua-13516	166	27	.	.	PUNCT
aiua-13516	167	1	11	11	NUM
aiua-13516	167	2	genes	gene	NOUN
aiua-13516	167	3	being	be	AUX
aiua-13516	167	4	identified	identify	VERB
aiua-13516	167	5	at	at	ADP
aiua-13516	167	6	the	the	DET
aiua-13516	167	7	last	last	ADJ
aiua-13516	167	8	stage	stage	NOUN
aiua-13516	167	9	have	have	AUX
aiua-13516	167	10	been	be	AUX
aiua-13516	167	11	found	find	VERB
aiua-13516	167	12	to	to	PART
aiua-13516	167	13	be	be	AUX
aiua-13516	167	14	correlated	correlate	VERB
aiua-13516	167	15	with	with	ADP
aiua-13516	167	16	overall	overall	ADJ
aiua-13516	167	17	survival	survival	NOUN
aiua-13516	167	18	period	period	NOUN
aiua-13516	167	19	(	(	PUNCT
aiua-13516	167	20	p	p	X
aiua-13516	167	21	<	<	X
aiua-13516	167	22	0.001	0.001	NUM
aiua-13516	167	23	)	)	PUNCT
aiua-13516	167	24	.	.	PUNCT
aiua-13516	168	1	following	follow	VERB
aiua-13516	168	2	this	this	DET
aiua-13516	168	3	critical	critical	ADJ
aiua-13516	168	4	evaluation	evaluation	NOUN
aiua-13516	168	5	based	base	VERB
aiua-13516	168	6	on	on	ADP
aiua-13516	168	7	the	the	DET
aiua-13516	168	8	pca	pca	NOUN
aiua-13516	168	9	algorithm	algorithm	NOUN
aiua-13516	168	10	used	use	VERB
aiua-13516	168	11	,	,	PUNCT
aiua-13516	168	12	we	we	PRON
aiua-13516	168	13	established	establish	VERB
aiua-13516	168	14	a	a	DET
aiua-13516	168	15	lactylation	lactylation	NOUN
aiua-13516	168	16	score	score	NOUN
aiua-13516	168	17	depending	depend	VERB
aiua-13516	168	18	on	on	ADP
aiua-13516	168	19	these	these	DET
aiua-13516	168	20	11	11	NUM
aiua-13516	168	21	prognostic	prognostic	ADJ
aiua-13516	168	22	genes	gene	NOUN
aiua-13516	168	23	.	.	PUNCT
aiua-13516	169	1	in	in	ADP
aiua-13516	169	2	addition	addition	NOUN
aiua-13516	169	3	to	to	ADP
aiua-13516	169	4	the	the	DET
aiua-13516	169	5	poorer	poor	ADJ
aiua-13516	169	6	survival	survival	NOUN
aiua-13516	169	7	rates	rate	NOUN
aiua-13516	169	8	observed	observe	VERB
aiua-13516	169	9	in	in	ADP
aiua-13516	169	10	patients	patient	NOUN
aiua-13516	169	11	with	with	ADP
aiua-13516	169	12	high	high	ADJ
aiua-13516	169	13	lactylation	lactylation	NOUN
aiua-13516	169	14	scores	score	NOUN
aiua-13516	169	15	;	;	PUNCT
aiua-13516	169	16	the	the	DET
aiua-13516	169	17	correlation	correlation	NOUN
aiua-13516	169	18	between	between	ADP
aiua-13516	169	19	the	the	DET
aiua-13516	169	20	lactylation	lactylation	NOUN
aiua-13516	169	21	score	score	NOUN
aiua-13516	169	22	and	and	CCONJ
aiua-13516	169	23	immune	immune	ADJ
aiua-13516	169	24	cell	cell	NOUN
aiua-13516	169	25	infiltration	infiltration	NOUN
aiua-13516	169	26	suggested	suggest	VERB
aiua-13516	169	27	a	a	DET
aiua-13516	169	28	positive	positive	ADJ
aiua-13516	169	29	association	association	NOUN
aiua-13516	169	30	between	between	ADP
aiua-13516	169	31	these	these	DET
aiua-13516	169	32	two	two	NUM
aiua-13516	169	33	variables	variable	NOUN
aiua-13516	169	34	.	.	PUNCT
aiua-13516	170	1	among	among	ADP
aiua-13516	170	2	the	the	DET
aiua-13516	170	3	11	11	NUM
aiua-13516	170	4	genes	gene	NOUN
aiua-13516	170	5	included	include	VERB
aiua-13516	170	6	in	in	ADP
aiua-13516	170	7	the	the	DET
aiua-13516	170	8	established	establish	VERB
aiua-13516	170	9	lactylation	lactylation	NOUN
aiua-13516	170	10	score	score	NOUN
aiua-13516	170	11	,	,	PUNCT
aiua-13516	170	12	clic3、tcirg1	clic3、tcirg1	PROPN
aiua-13516	170	13	、	、	NOUN
aiua-13516	170	14	s100a8	s100a8	PROPN
aiua-13516	170	15	and	and	CCONJ
aiua-13516	170	16	lgals1	lgals1	NOUN
aiua-13516	170	17	were	be	AUX
aiua-13516	170	18	found	find	VERB
aiua-13516	170	19	to	to	PART
aiua-13516	170	20	be	be	AUX
aiua-13516	170	21	related	relate	VERB
aiua-13516	170	22	to	to	ADP
aiua-13516	170	23	glycolysis	glycolysis	NOUN
aiua-13516	170	24	and	and	CCONJ
aiua-13516	170	25	lactate	lactate	NOUN
aiua-13516	170	26	regulation	regulation	NOUN
aiua-13516	170	27	in	in	ADP
aiua-13516	170	28	tumor	tumor	NOUN
aiua-13516	170	29	cells	cell	NOUN
aiua-13516	170	30	.	.	PUNCT
aiua-13516	171	1	clic3	clic3	NOUN
aiua-13516	171	2	and	and	CCONJ
aiua-13516	171	3	tcirg1	tcirg1	PROPN
aiua-13516	171	4	,	,	PUNCT
aiua-13516	171	5	as	as	ADP
aiua-13516	171	6	a	a	DET
aiua-13516	171	7	member	member	NOUN
aiua-13516	171	8	of	of	ADP
aiua-13516	171	9	the	the	DET
aiua-13516	171	10	chloride	chloride	NOUN
aiua-13516	171	11	intracellular	intracellular	ADJ
aiua-13516	171	12	channel	channel	NOUN
aiua-13516	171	13	protein	protein	NOUN
aiua-13516	171	14	family	family	NOUN
aiua-13516	171	15	and	and	CCONJ
aiua-13516	171	16	a	a	DET
aiua-13516	171	17	subunit	subunit	NOUN
aiua-13516	171	18	of	of	ADP
aiua-13516	171	19	a	a	DET
aiua-13516	171	20	large	large	ADJ
aiua-13516	171	21	protein	protein	NOUN
aiua-13516	171	22	complex	complex	NOUN
aiua-13516	171	23	known	know	VERB
aiua-13516	171	24	as	as	ADP
aiua-13516	171	25	a	a	DET
aiua-13516	171	26	vacuolar	vacuolar	ADJ
aiua-13516	171	27	h+-atpase	h+-atpase	NOUN
aiua-13516	171	28	(	(	PUNCT
aiua-13516	171	29	v	v	NOUN
aiua-13516	171	30	-	-	PUNCT
aiua-13516	171	31	atpase	atpase	NOUN
aiua-13516	171	32	)	)	PUNCT
aiua-13516	171	33	respectively	respectively	ADV
aiua-13516	171	34	,	,	PUNCT
aiua-13516	171	35	play	play	VERB
aiua-13516	171	36	important	important	ADJ
aiua-13516	171	37	roles	role	NOUN
aiua-13516	171	38	in	in	ADP
aiua-13516	171	39	regulating	regulate	VERB
aiua-13516	171	40	the	the	DET
aiua-13516	171	41	ph	ph	NOUN
aiua-13516	171	42	of	of	ADP
aiua-13516	171	43	cells	cell	NOUN
aiua-13516	171	44	and	and	CCONJ
aiua-13516	171	45	their	their	PRON
aiua-13516	171	46	surrounding	surround	VERB
aiua-13516	171	47	environment	environment	NOUN
aiua-13516	171	48	(	(	PUNCT
aiua-13516	171	49	32	32	NUM
aiua-13516	171	50	,	,	PUNCT
aiua-13516	171	51	33	33	NUM
aiua-13516	171	52	)	)	PUNCT
aiua-13516	171	53	.	.	PUNCT
aiua-13516	172	1	the	the	DET
aiua-13516	172	2	acidification	acidification	NOUN
aiua-13516	172	3	of	of	ADP
aiua-13516	172	4	the	the	DET
aiua-13516	172	5	tumor	tumor	NOUN
aiua-13516	172	6	microenvironment	microenvironment	NOUN
aiua-13516	172	7	(	(	PUNCT
aiua-13516	172	8	tme	tme	NOUN
aiua-13516	172	9	)	)	PUNCT
aiua-13516	172	10	can	can	AUX
aiua-13516	172	11	regulate	regulate	VERB
aiua-13516	172	12	glycolysis	glycolysis	NOUN
aiua-13516	172	13	in	in	ADP
aiua-13516	172	14	cells	cell	NOUN
aiua-13516	172	15	and	and	CCONJ
aiua-13516	172	16	mediate	mediate	VERB
aiua-13516	172	17	the	the	DET
aiua-13516	172	18	production	production	NOUN
aiua-13516	172	19	of	of	ADP
aiua-13516	172	20	lactate	lactate	NOUN
aiua-13516	172	21	,	,	PUNCT
aiua-13516	172	22	thereby	thereby	ADV
aiua-13516	172	23	regulating	regulate	VERB
aiua-13516	172	24	the	the	DET
aiua-13516	172	25	lactylation	lactylation	NOUN
aiua-13516	172	26	modification	modification	NOUN
aiua-13516	172	27	of	of	ADP
aiua-13516	172	28	proteins	protein	NOUN
aiua-13516	172	29	(	(	PUNCT
aiua-13516	172	30	34	34	NUM
aiua-13516	172	31	)	)	PUNCT
aiua-13516	172	32	.	.	PUNCT
aiua-13516	173	1	s100a8	s100a8	PROPN
aiua-13516	173	2	is	be	AUX
aiua-13516	173	3	a	a	DET
aiua-13516	173	4	member	member	NOUN
aiua-13516	173	5	of	of	ADP
aiua-13516	173	6	the	the	DET
aiua-13516	173	7	s100	s100	PROPN
aiua-13516	173	8	family	family	NOUN
aiua-13516	173	9	of	of	ADP
aiua-13516	173	10	proteins	protein	NOUN
aiua-13516	173	11	containing	contain	VERB
aiua-13516	173	12	2	2	NUM
aiua-13516	173	13	ef	ef	ADJ
aiua-13516	173	14	-	-	PUNCT
aiua-13516	173	15	hand	hand	NOUN
aiua-13516	173	16	calcium	calcium	NOUN
aiua-13516	173	17	-	-	PUNCT
aiua-13516	173	18	binding	bind	VERB
aiua-13516	173	19	motifs	motif	NOUN
aiua-13516	173	20	.	.	PUNCT
aiua-13516	174	1	it	it	PRON
aiua-13516	174	2	is	be	AUX
aiua-13516	174	3	involved	involve	VERB
aiua-13516	174	4	in	in	ADP
aiua-13516	174	5	the	the	DET
aiua-13516	174	6	regulation	regulation	NOUN
aiua-13516	174	7	of	of	ADP
aiua-13516	174	8	a	a	DET
aiua-13516	174	9	number	number	NOUN
aiua-13516	174	10	of	of	ADP
aiua-13516	174	11	cellular	cellular	ADJ
aiua-13516	174	12	processes	process	NOUN
aiua-13516	174	13	such	such	ADJ
aiua-13516	174	14	as	as	ADP
aiua-13516	174	15	cell	cell	NOUN
aiua-13516	174	16	cycle	cycle	NOUN
aiua-13516	174	17	progression	progression	NOUN
aiua-13516	174	18	and	and	CCONJ
aiua-13516	174	19	differentiation	differentiation	NOUN
aiua-13516	174	20	.	.	PUNCT
aiua-13516	175	1	according	accord	VERB
aiua-13516	175	2	to	to	ADP
aiua-13516	175	3	a	a	DET
aiua-13516	175	4	recent	recent	ADJ
aiua-13516	175	5	study	study	NOUN
aiua-13516	175	6	,	,	PUNCT
aiua-13516	175	7	s100a8	s100a8	PROPN
aiua-13516	175	8	also	also	ADV
aiua-13516	175	9	play	play	VERB
aiua-13516	175	10	a	a	DET
aiua-13516	175	11	critical	critical	ADJ
aiua-13516	175	12	role	role	NOUN
aiua-13516	175	13	in	in	ADP
aiua-13516	175	14	promoting	promote	VERB
aiua-13516	175	15	macrophage	macrophage	ADJ
aiua-13516	175	16	perturbation	perturbation	NOUN
aiua-13516	175	17	and	and	CCONJ
aiua-13516	175	18	glycolysis	glycolysis	NOUN
aiua-13516	175	19	through	through	ADP
aiua-13516	175	20	the	the	DET
aiua-13516	175	21	tlr4	tlr4	PROPN
aiua-13516	175	22	/	/	SYM
aiua-13516	175	23	myd88	myd88	PROPN
aiua-13516	175	24	/	/	SYM
aiua-13516	175	25	nf	nf	PROPN
aiua-13516	175	26	-	-	PUNCT
aiua-13516	175	27	κb	κb	NOUN
aiua-13516	175	28	signaling	signal	VERB
aiua-13516	175	29	pathway	pathway	NOUN
aiua-13516	175	30	(	(	PUNCT
aiua-13516	175	31	35	35	NUM
aiua-13516	175	32	)	)	PUNCT
aiua-13516	175	33	.	.	PUNCT
aiua-13516	176	1	lgals1	lgals1	PROPN
aiua-13516	176	2	,	,	PUNCT
aiua-13516	176	3	also	also	ADV
aiua-13516	176	4	known	know	VERB
aiua-13516	176	5	as	as	ADP
aiua-13516	176	6	gal-1	gal-1	VERB
aiua-13516	176	7	,	,	PUNCT
aiua-13516	176	8	is	be	AUX
aiua-13516	176	9	a	a	DET
aiua-13516	176	10	member	member	NOUN
aiua-13516	176	11	of	of	ADP
aiua-13516	176	12	the	the	DET
aiua-13516	176	13	family	family	NOUN
aiua-13516	176	14	of	of	ADP
aiua-13516	176	15	beta	beta	NOUN
aiua-13516	176	16	-	-	PUNCT
aiua-13516	176	17	galactoside	galactoside	NOUN
aiua-13516	176	18	-	-	PUNCT
aiua-13516	176	19	binding	bind	VERB
aiua-13516	176	20	proteins	protein	NOUN
aiua-13516	176	21	implicated	implicate	VERB
aiua-13516	176	22	in	in	ADP
aiua-13516	176	23	modulating	modulate	VERB
aiua-13516	176	24	cell	cell	NOUN
aiua-13516	176	25	-	-	PUNCT
aiua-13516	176	26	cell	cell	NOUN
aiua-13516	176	27	and	and	CCONJ
aiua-13516	176	28	cell	cell	NOUN
aiua-13516	176	29	-	-	PUNCT
aiua-13516	176	30	matrix	matrix	NOUN
aiua-13516	176	31	interactions	interaction	NOUN
aiua-13516	176	32	.	.	PUNCT
aiua-13516	177	1	previous	previous	ADJ
aiua-13516	177	2	study	study	NOUN
aiua-13516	177	3	had	have	AUX
aiua-13516	177	4	revealed	reveal	VERB
aiua-13516	177	5	that	that	SCONJ
aiua-13516	177	6	the	the	DET
aiua-13516	177	7	tlr4	tlr4	NOUN
aiua-13516	177	8	/	/	SYM
aiua-13516	177	9	gal-1	gal-1	VERB
aiua-13516	177	10	signaling	signal	VERB
aiua-13516	177	11	pathway	pathway	NOUN
aiua-13516	177	12	could	could	AUX
aiua-13516	177	13	regulate	regulate	VERB
aiua-13516	177	14	lactate	lactate	NOUN
aiua-13516	177	15	-	-	PUNCT
aiua-13516	177	16	mediated	mediate	VERB
aiua-13516	177	17	emt	emt	NOUN
aiua-13516	177	18	processes	process	NOUN
aiua-13516	177	19	in	in	ADP
aiua-13516	177	20	crc	crc	NOUN
aiua-13516	177	21	cells	cell	NOUN
aiua-13516	177	22	(	(	PUNCT
aiua-13516	177	23	36	36	NUM
aiua-13516	177	24	)	)	PUNCT
aiua-13516	177	25	.	.	PUNCT
aiua-13516	178	1	although	although	SCONJ
aiua-13516	178	2	no	no	DET
aiua-13516	178	3	studies	study	NOUN
aiua-13516	178	4	have	have	AUX
aiua-13516	178	5	revealed	reveal	VERB
aiua-13516	178	6	that	that	SCONJ
aiua-13516	178	7	the	the	DET
aiua-13516	178	8	other	other	ADJ
aiua-13516	178	9	seven	seven	NUM
aiua-13516	178	10	genes	gene	NOUN
aiua-13516	178	11	are	be	AUX
aiua-13516	178	12	directly	directly	ADV
aiua-13516	178	13	or	or	CCONJ
aiua-13516	178	14	indirectly	indirectly	ADV
aiua-13516	178	15	related	relate	VERB
aiua-13516	178	16	to	to	ADP
aiua-13516	178	17	lactylation	lactylation	NOUN
aiua-13516	178	18	modification	modification	NOUN
aiua-13516	178	19	,	,	PUNCT
aiua-13516	178	20	many	many	ADJ
aiua-13516	178	21	studies	study	NOUN
aiua-13516	178	22	have	have	AUX
aiua-13516	178	23	reported	report	VERB
aiua-13516	178	24	that	that	SCONJ
aiua-13516	178	25	they	they	PRON
aiua-13516	178	26	are	be	AUX
aiua-13516	178	27	closely	closely	ADV
aiua-13516	178	28	related	relate	VERB
aiua-13516	178	29	to	to	ADP
aiua-13516	178	30	the	the	DET
aiua-13516	178	31	occurrence	occurrence	NOUN
aiua-13516	178	32	and	and	CCONJ
aiua-13516	178	33	development	development	NOUN
aiua-13516	178	34	of	of	ADP
aiua-13516	178	35	bladder	bladder	NOUN
aiua-13516	178	36	cancer	cancer	NOUN
aiua-13516	178	37	.	.	PUNCT
aiua-13516	179	1	among	among	ADP
aiua-13516	179	2	them	they	PRON
aiua-13516	179	3	,	,	PUNCT
aiua-13516	179	4	sphk1	sphk1	NOUN
aiua-13516	179	5	,	,	PUNCT
aiua-13516	179	6	rcn3	rcn3	PROPN
aiua-13516	179	7	,	,	PUNCT
aiua-13516	179	8	cda	cda	PROPN
aiua-13516	179	9	,	,	PUNCT
aiua-13516	179	10	tbx3	tbx3	PROPN
aiua-13516	179	11	,	,	PUNCT
aiua-13516	179	12	aebp1	aebp1	PROPN
aiua-13516	179	13	and	and	CCONJ
aiua-13516	179	14	krt16	krt16	PROPN
aiua-13516	179	15	are	be	AUX
aiua-13516	179	16	widely	widely	ADV
aiua-13516	179	17	reported	report	VERB
aiua-13516	179	18	oncogenes	oncogene	NOUN
aiua-13516	179	19	.	.	PUNCT
aiua-13516	180	1	it	it	PRON
aiua-13516	180	2	can	can	AUX
aiua-13516	180	3	regulate	regulate	VERB
aiua-13516	180	4	cell	cell	NOUN
aiua-13516	180	5	apoptosis	apoptosis	NOUN
aiua-13516	180	6	,	,	PUNCT
aiua-13516	180	7	promote	promote	VERB
aiua-13516	180	8	cell	cell	NOUN
aiua-13516	180	9	proliferation	proliferation	NOUN
aiua-13516	180	10	,	,	PUNCT
aiua-13516	180	11	migration	migration	NOUN
aiua-13516	180	12	,	,	PUNCT
aiua-13516	180	13	or	or	CCONJ
aiua-13516	180	14	resist	resist	VERB
aiua-13516	180	15	immune	immune	ADJ
aiua-13516	180	16	killing	killing	NOUN
aiua-13516	180	17	by	by	ADP
aiua-13516	180	18	activating	activate	VERB
aiua-13516	180	19	stat3	stat3	NOUN
aiua-13516	180	20	and	and	CCONJ
aiua-13516	180	21	nf	nf	ADJ
aiua-13516	180	22	-	-	PUNCT
aiua-13516	180	23	κb	κb	NOUN
aiua-13516	180	24	signaling	signal	VERB
aiua-13516	180	25	pathways	pathway	NOUN
aiua-13516	180	26	,	,	PUNCT
aiua-13516	180	27	participating	participate	VERB
aiua-13516	180	28	in	in	ADP
aiua-13516	180	29	collagen	collagen	NOUN
aiua-13516	180	30	biosynthesis	biosynthesis	NOUN
aiua-13516	180	31	,	,	PUNCT
aiua-13516	180	32	inducing	induce	VERB
aiua-13516	180	33	specific	specific	ADJ
aiua-13516	180	34	gene	gene	NOUN
aiua-13516	180	35	mutations	mutation	NOUN
aiua-13516	180	36	,	,	PUNCT
aiua-13516	180	37	or	or	CCONJ
aiua-13516	180	38	acting	act	VERB
aiua-13516	180	39	as	as	ADP
aiua-13516	180	40	transcriptional	transcriptional	ADJ
aiua-13516	180	41	promoters	promoter	NOUN
aiua-13516	180	42	(	(	PUNCT
aiua-13516	180	43	37	37	NUM
aiua-13516	180	44	-	-	SYM
aiua-13516	180	45	43	43	NUM
aiua-13516	180	46	)	)	PUNCT
aiua-13516	180	47	.	.	PUNCT
aiua-13516	181	1	tp53inp1	tp53inp1	PROPN
aiua-13516	181	2	has	have	AUX
aiua-13516	181	3	been	be	AUX
aiua-13516	181	4	reported	report	VERB
aiua-13516	181	5	to	to	PART
aiua-13516	181	6	be	be	AUX
aiua-13516	181	7	a	a	DET
aiua-13516	181	8	tumor	tumor	NOUN
aiua-13516	181	9	suppressor	suppressor	NOUN
aiua-13516	181	10	gene	gene	NOUN
aiua-13516	181	11	in	in	ADP
aiua-13516	181	12	bladder	bladder	NOUN
aiua-13516	181	13	cancer	cancer	NOUN
aiua-13516	181	14	,	,	PUNCT
aiua-13516	181	15	which	which	PRON
aiua-13516	181	16	can	can	AUX
aiua-13516	181	17	inhibit	inhibit	VERB
aiua-13516	181	18	the	the	DET
aiua-13516	181	19	migration	migration	NOUN
aiua-13516	181	20	and	and	CCONJ
aiua-13516	181	21	invasion	invasion	NOUN
aiua-13516	181	22	of	of	ADP
aiua-13516	181	23	bladder	bladder	NOUN
aiua-13516	181	24	cancer	cancer	NOUN
aiua-13516	181	25	cells	cell	NOUN
aiua-13516	181	26	by	by	ADP
aiua-13516	181	27	inducing	induce	VERB
aiua-13516	181	28	autophagy	autophagy	NOUN
aiua-13516	181	29	and	and	CCONJ
aiua-13516	181	30	inhibiting	inhibit	VERB
aiua-13516	181	31	the	the	DET
aiua-13516	181	32	activation	activation	NOUN
aiua-13516	181	33	of	of	ADP
aiua-13516	181	34	extracellular	extracellular	ADJ
aiua-13516	181	35	regulated	regulated	ADJ
aiua-13516	181	36	kinase	kinase	NOUN
aiua-13516	181	37	(	(	PUNCT
aiua-13516	181	38	erk	erk	PROPN
aiua-13516	181	39	)	)	PUNCT
aiua-13516	181	40	(	(	PUNCT
aiua-13516	181	41	44	44	NUM
aiua-13516	181	42	)	)	PUNCT
aiua-13516	181	43	.	.	PUNCT
aiua-13516	182	1	the	the	DET
aiua-13516	182	2	effectiveness	effectiveness	NOUN
aiua-13516	182	3	of	of	ADP
aiua-13516	182	4	an	an	DET
aiua-13516	182	5	ici	ici	NOUN
aiua-13516	182	6	treatment	treatment	NOUN
aiua-13516	182	7	can	can	AUX
aiua-13516	182	8	be	be	AUX
aiua-13516	182	9	predicted	predict	VERB
aiua-13516	182	10	by	by	ADP
aiua-13516	182	11	chemokines	chemokine	NOUN
aiua-13516	182	12	,	,	PUNCT
aiua-13516	182	13	chemokine	chemokine	ADJ
aiua-13516	182	14	receptors	receptor	NOUN
aiua-13516	182	15	,	,	PUNCT
aiua-13516	182	16	and	and	CCONJ
aiua-13516	182	17	immune	immune	ADJ
aiua-13516	182	18	checkpoints	checkpoint	NOUN
aiua-13516	182	19	(	(	PUNCT
aiua-13516	182	20	45	45	NUM
aiua-13516	182	21	,	,	PUNCT
aiua-13516	182	22	46	46	NUM
aiua-13516	182	23	)	)	PUNCT
aiua-13516	182	24	.	.	PUNCT
aiua-13516	183	1	chemokines	chemokine	NOUN
aiua-13516	183	2	are	be	AUX
aiua-13516	183	3	critical	critical	ADJ
aiua-13516	183	4	in	in	ADP
aiua-13516	183	5	directing	direct	VERB
aiua-13516	183	6	immune	immune	ADJ
aiua-13516	183	7	cell	cell	NOUN
aiua-13516	183	8	migration	migration	NOUN
aiua-13516	183	9	necessary	necessary	ADJ
aiua-13516	183	10	to	to	PART
aiua-13516	183	11	mount	mount	VERB
aiua-13516	183	12	and	and	CCONJ
aiua-13516	183	13	deliver	deliver	VERB
aiua-13516	183	14	an	an	DET
aiua-13516	183	15	effective	effective	ADJ
aiua-13516	183	16	antitumor	antitumor	PROPN
aiua-13516	183	17	immune	immune	ADJ
aiua-13516	183	18	response	response	NOUN
aiua-13516	183	19	.	.	PUNCT
aiua-13516	184	1	chemokine	chemokine	ADJ
aiua-13516	184	2	secretion	secretion	NOUN
aiua-13516	184	3	is	be	AUX
aiua-13516	184	4	often	often	ADV
aiua-13516	184	5	altered	alter	VERB
aiua-13516	184	6	in	in	ADP
aiua-13516	184	7	the	the	DET
aiua-13516	184	8	tme	tme	NOUN
aiua-13516	184	9	,	,	PUNCT
aiua-13516	184	10	and	and	CCONJ
aiua-13516	184	11	an	an	DET
aiua-13516	184	12	aberrant	aberrant	ADJ
aiua-13516	184	13	chemokine	chemokine	ADJ
aiua-13516	184	14	profile	profile	NOUN
aiua-13516	184	15	can	can	AUX
aiua-13516	184	16	facilitate	facilitate	VERB
aiua-13516	184	17	the	the	DET
aiua-13516	184	18	differentiation	differentiation	NOUN
aiua-13516	184	19	and	and	CCONJ
aiua-13516	184	20	infiltration	infiltration	NOUN
aiua-13516	184	21	of	of	ADP
aiua-13516	184	22	immunosuppressive	immunosuppressive	ADJ
aiua-13516	184	23	pro	pro	ADJ
aiua-13516	184	24	-	-	ADJ
aiua-13516	184	25	tumorigenic	tumorigenic	ADJ
aiua-13516	184	26	cells	cell	NOUN
aiua-13516	184	27	into	into	ADP
aiua-13516	184	28	the	the	DET
aiua-13516	184	29	tumor	tumor	NOUN
aiua-13516	184	30	,	,	PUNCT
aiua-13516	184	31	namely	namely	ADV
aiua-13516	184	32	treg	treg	PROPN
aiua-13516	184	33	cells	cell	NOUN
aiua-13516	184	34	,	,	PUNCT
aiua-13516	184	35	mdscs	mdsc	NOUN
aiua-13516	184	36	and	and	CCONJ
aiua-13516	184	37	tams	tam	NOUN
aiua-13516	184	38	.	.	PUNCT
aiua-13516	185	1	due	due	ADP
aiua-13516	185	2	to	to	ADP
aiua-13516	185	3	their	their	PRON
aiua-13516	185	4	multifaceted	multifaceted	ADJ
aiua-13516	185	5	role	role	NOUN
aiua-13516	185	6	in	in	ADP
aiua-13516	185	7	the	the	DET
aiua-13516	185	8	tumor	tumor	NOUN
aiua-13516	185	9	immune	immune	ADJ
aiua-13516	185	10	response	response	NOUN
aiua-13516	185	11	and	and	CCONJ
aiua-13516	185	12	tumor	tumor	NOUN
aiua-13516	185	13	biology	biology	NOUN
aiua-13516	185	14	,	,	PUNCT
aiua-13516	185	15	the	the	DET
aiua-13516	185	16	chemokine	chemokine	ADJ
aiua-13516	185	17	network	network	NOUN
aiua-13516	185	18	has	have	AUX
aiua-13516	185	19	emerged	emerge	VERB
aiua-13516	185	20	as	as	ADP
aiua-13516	185	21	a	a	DET
aiua-13516	185	22	potential	potential	ADJ
aiua-13516	185	23	archivio	archivio	NOUN
aiua-13516	185	24	italiano	italiano	NOUN
aiua-13516	185	25	di	di	X
aiua-13516	185	26	urologia	urologia	PROPN
aiua-13516	185	27	e	e	PROPN
aiua-13516	185	28	andrologia	andrologia	NOUN
aiua-13516	185	29	2025	2025	NUM
aiua-13516	185	30	;	;	PUNCT
aiua-13516	185	31	97(1):13516	97(1):13516	NUM
aiua-13516	185	32	11	11	NUM
aiua-13516	185	33	lactylation	lactylation	NOUN
aiua-13516	185	34	-	-	PUNCT
aiua-13516	185	35	related	relate	VERB
aiua-13516	185	36	gene	gene	NOUN
aiua-13516	185	37	signature	signature	NOUN
aiua-13516	185	38	in	in	ADP
aiua-13516	185	39	bladder	bladder	NOUN
aiua-13516	185	40	cancer	cancer	NOUN
aiua-13516	185	41	immunotherapy	immunotherapy	NOUN
aiua-13516	185	42	target	target	NOUN
aiua-13516	185	43	(	(	PUNCT
aiua-13516	185	44	47	47	NUM
aiua-13516	185	45	)	)	PUNCT
aiua-13516	185	46	.	.	PUNCT
aiua-13516	186	1	in	in	ADP
aiua-13516	186	2	addition	addition	NOUN
aiua-13516	186	3	,	,	PUNCT
aiua-13516	186	4	immune	immune	ADJ
aiua-13516	186	5	checkpoints	checkpoint	NOUN
aiua-13516	186	6	are	be	AUX
aiua-13516	186	7	another	another	DET
aiua-13516	186	8	key	key	ADJ
aiua-13516	186	9	regulator	regulator	NOUN
aiua-13516	186	10	of	of	ADP
aiua-13516	186	11	the	the	DET
aiua-13516	186	12	tumour	tumour	ADJ
aiua-13516	186	13	immune	immune	ADJ
aiua-13516	186	14	response	response	NOUN
aiua-13516	186	15	.	.	PUNCT
aiua-13516	187	1	normally	normally	ADV
aiua-13516	187	2	,	,	PUNCT
aiua-13516	187	3	the	the	DET
aiua-13516	187	4	presence	presence	NOUN
aiua-13516	187	5	of	of	ADP
aiua-13516	187	6	immune	immune	ADJ
aiua-13516	187	7	checkpoints	checkpoint	NOUN
aiua-13516	187	8	avoids	avoid	VERB
aiua-13516	187	9	the	the	DET
aiua-13516	187	10	damage	damage	NOUN
aiua-13516	187	11	caused	cause	VERB
aiua-13516	187	12	by	by	ADP
aiua-13516	187	13	excessive	excessive	ADJ
aiua-13516	187	14	immune	immune	ADJ
aiua-13516	187	15	response	response	NOUN
aiua-13516	187	16	,	,	PUNCT
aiua-13516	187	17	but	but	CCONJ
aiua-13516	187	18	tumour	tumour	NOUN
aiua-13516	187	19	cells	cell	NOUN
aiua-13516	187	20	can	can	AUX
aiua-13516	187	21	escape	escape	VERB
aiua-13516	187	22	from	from	ADP
aiua-13516	187	23	the	the	DET
aiua-13516	187	24	immune	immune	ADJ
aiua-13516	187	25	system	system	NOUN
aiua-13516	187	26	by	by	ADP
aiua-13516	187	27	expressing	express	VERB
aiua-13516	187	28	corresponding	correspond	VERB
aiua-13516	187	29	ligands	ligand	NOUN
aiua-13516	187	30	that	that	PRON
aiua-13516	187	31	bind	bind	VERB
aiua-13516	187	32	to	to	ADP
aiua-13516	187	33	them	they	PRON
aiua-13516	187	34	,	,	PUNCT
aiua-13516	187	35	activating	activate	VERB
aiua-13516	187	36	inhibitory	inhibitory	ADJ
aiua-13516	187	37	pathways	pathway	NOUN
aiua-13516	187	38	or	or	CCONJ
aiua-13516	187	39	inhibitory	inhibitory	ADJ
aiua-13516	187	40	immune	immune	ADJ
aiua-13516	187	41	checkpoints	checkpoint	NOUN
aiua-13516	187	42	within	within	ADP
aiua-13516	187	43	the	the	DET
aiua-13516	187	44	immune	immune	ADJ
aiua-13516	187	45	cells	cell	NOUN
aiua-13516	187	46	,	,	PUNCT
aiua-13516	187	47	inhibiting	inhibit	VERB
aiua-13516	187	48	immune	immune	ADJ
aiua-13516	187	49	cell	cell	NOUN
aiua-13516	187	50	activity	activity	NOUN
aiua-13516	187	51	or	or	CCONJ
aiua-13516	187	52	mediating	mediate	VERB
aiua-13516	187	53	apoptosis	apoptosis	NOUN
aiua-13516	187	54	of	of	ADP
aiua-13516	187	55	immune	immune	ADJ
aiua-13516	187	56	cells	cell	NOUN
aiua-13516	187	57	.	.	PUNCT
aiua-13516	188	1	immune	immune	ADJ
aiua-13516	188	2	checkpoint	checkpoint	NOUN
aiua-13516	188	3	inhibitors	inhibitor	NOUN
aiua-13516	188	4	can	can	AUX
aiua-13516	188	5	enhance	enhance	VERB
aiua-13516	188	6	the	the	DET
aiua-13516	188	7	immune	immune	ADJ
aiua-13516	188	8	attack	attack	NOUN
aiua-13516	188	9	against	against	ADP
aiua-13516	188	10	tumours	tumour	NOUN
aiua-13516	188	11	by	by	ADP
aiua-13516	188	12	blocking	block	VERB
aiua-13516	188	13	the	the	DET
aiua-13516	188	14	interaction	interaction	NOUN
aiua-13516	188	15	of	of	ADP
aiua-13516	188	16	these	these	DET
aiua-13516	188	17	immune	immune	ADJ
aiua-13516	188	18	checkpoint	checkpoint	NOUN
aiua-13516	188	19	proteins	protein	NOUN
aiua-13516	188	20	with	with	ADP
aiua-13516	188	21	their	their	PRON
aiua-13516	188	22	ligands	ligand	NOUN
aiua-13516	188	23	and	and	CCONJ
aiua-13516	188	24	preventing	prevent	VERB
aiua-13516	188	25	the	the	DET
aiua-13516	188	26	inactivation	inactivation	NOUN
aiua-13516	188	27	of	of	ADP
aiua-13516	188	28	t	t	NOUN
aiua-13516	188	29	-	-	PUNCT
aiua-13516	188	30	cell	cell	NOUN
aiua-13516	188	31	function	function	NOUN
aiua-13516	188	32	(	(	PUNCT
aiua-13516	188	33	48	48	NUM
aiua-13516	188	34	)	)	PUNCT
aiua-13516	188	35	.	.	PUNCT
aiua-13516	189	1	our	our	PRON
aiua-13516	189	2	results	result	NOUN
aiua-13516	189	3	reveal	reveal	VERB
aiua-13516	189	4	that	that	SCONJ
aiua-13516	189	5	high	high	ADJ
aiua-13516	189	6	expression	expression	NOUN
aiua-13516	189	7	levels	level	NOUN
aiua-13516	189	8	of	of	ADP
aiua-13516	189	9	chemokines	chemokine	NOUN
aiua-13516	189	10	,	,	PUNCT
aiua-13516	189	11	chemokine	chemokine	ADJ
aiua-13516	189	12	receptors	receptor	NOUN
aiua-13516	189	13	,	,	PUNCT
aiua-13516	189	14	and	and	CCONJ
aiua-13516	189	15	immune	immune	ADJ
aiua-13516	189	16	checkpoints	checkpoint	NOUN
aiua-13516	189	17	were	be	AUX
aiua-13516	189	18	observed	observe	VERB
aiua-13516	189	19	in	in	ADP
aiua-13516	189	20	the	the	DET
aiua-13516	189	21	group	group	NOUN
aiua-13516	189	22	with	with	ADP
aiua-13516	189	23	high	high	ADJ
aiua-13516	189	24	lactylation	lactylation	NOUN
aiua-13516	189	25	scores	score	NOUN
aiua-13516	189	26	,	,	PUNCT
aiua-13516	189	27	which	which	PRON
aiua-13516	189	28	indicated	indicate	VERB
aiua-13516	189	29	although	although	SCONJ
aiua-13516	189	30	high	high	ADJ
aiua-13516	189	31	lactylation	lactylation	NOUN
aiua-13516	189	32	score	score	NOUN
aiua-13516	189	33	is	be	AUX
aiua-13516	189	34	a	a	DET
aiua-13516	189	35	poor	poor	ADJ
aiua-13516	189	36	prognostic	prognostic	ADJ
aiua-13516	189	37	factor	factor	NOUN
aiua-13516	189	38	for	for	ADP
aiua-13516	189	39	blca	blca	ADJ
aiua-13516	189	40	,	,	PUNCT
aiua-13516	189	41	patients	patient	NOUN
aiua-13516	189	42	with	with	ADP
aiua-13516	189	43	high	high	ADJ
aiua-13516	189	44	lactylation	lactylation	NOUN
aiua-13516	189	45	score	score	NOUN
aiua-13516	189	46	may	may	AUX
aiua-13516	189	47	respond	respond	VERB
aiua-13516	189	48	better	well	ADV
aiua-13516	189	49	to	to	ADP
aiua-13516	189	50	an	an	DET
aiua-13516	189	51	ici	ici	NOUN
aiua-13516	189	52	treatment	treatment	NOUN
aiua-13516	189	53	.	.	PUNCT
aiua-13516	190	1	this	this	DET
aiua-13516	190	2	finding	finding	NOUN
aiua-13516	190	3	is	be	AUX
aiua-13516	190	4	highly	highly	ADV
aiua-13516	190	5	valuable	valuable	ADJ
aiua-13516	190	6	in	in	ADP
aiua-13516	190	7	an	an	DET
aiua-13516	190	8	attempt	attempt	NOUN
aiua-13516	190	9	to	to	PART
aiua-13516	190	10	predict	predict	VERB
aiua-13516	190	11	the	the	DET
aiua-13516	190	12	efficacy	efficacy	NOUN
aiua-13516	190	13	of	of	ADP
aiua-13516	190	14	ici	ici	PROPN
aiua-13516	190	15	treatment	treatment	NOUN
aiua-13516	190	16	in	in	ADP
aiua-13516	190	17	a	a	DET
aiua-13516	190	18	reliable	reliable	ADJ
aiua-13516	190	19	manner	manner	NOUN
aiua-13516	190	20	in	in	ADP
aiua-13516	190	21	cases	case	NOUN
aiua-13516	190	22	with	with	ADP
aiua-13516	190	23	blca	blca	PROPN
aiua-13516	190	24	.	.	PUNCT
aiua-13516	191	1	the	the	DET
aiua-13516	191	2	analysis	analysis	NOUN
aiua-13516	191	3	of	of	ADP
aiua-13516	191	4	immunotherapy	immunotherapy	NOUN
aiua-13516	191	5	datasets	dataset	NOUN
aiua-13516	191	6	confirmed	confirm	VERB
aiua-13516	191	7	that	that	SCONJ
aiua-13516	191	8	patients	patient	NOUN
aiua-13516	191	9	with	with	ADP
aiua-13516	191	10	high	high	ADJ
aiua-13516	191	11	lactylation	lactylation	NOUN
aiua-13516	191	12	scores	score	NOUN
aiua-13516	191	13	had	have	VERB
aiua-13516	191	14	positive	positive	ADJ
aiua-13516	191	15	responses	response	NOUN
aiua-13516	191	16	to	to	ADP
aiua-13516	191	17	ici	ici	NOUN
aiua-13516	191	18	treatment	treatment	NOUN
aiua-13516	191	19	in	in	ADP
aiua-13516	191	20	the	the	DET
aiua-13516	191	21	imvigor210	imvigor210	PROPN
aiua-13516	191	22	and	and	CCONJ
aiua-13516	191	23	nct02684006	nct02684006	ADJ
aiua-13516	191	24	cohorts	cohort	NOUN
aiua-13516	191	25	.	.	PUNCT
aiua-13516	192	1	these	these	DET
aiua-13516	192	2	findings	finding	NOUN
aiua-13516	192	3	again	again	ADV
aiua-13516	192	4	further	far	ADV
aiua-13516	192	5	supported	support	VERB
aiua-13516	192	6	our	our	PRON
aiua-13516	192	7	findings	finding	NOUN
aiua-13516	192	8	.	.	PUNCT
aiua-13516	193	1	however	however	ADV
aiua-13516	193	2	,	,	PUNCT
aiua-13516	193	3	as	as	ADP
aiua-13516	193	4	a	a	DET
aiua-13516	193	5	bioinformatics	bioinformatics	NOUN
aiua-13516	193	6	-	-	PUNCT
aiua-13516	193	7	based	base	VERB
aiua-13516	193	8	analysis	analysis	NOUN
aiua-13516	193	9	,	,	PUNCT
aiua-13516	193	10	the	the	DET
aiua-13516	193	11	findings	finding	NOUN
aiua-13516	193	12	of	of	ADP
aiua-13516	193	13	this	this	DET
aiua-13516	193	14	study	study	NOUN
aiua-13516	193	15	are	be	AUX
aiua-13516	193	16	subjected	subject	VERB
aiua-13516	193	17	to	to	ADP
aiua-13516	193	18	several	several	ADJ
aiua-13516	193	19	limitations	limitation	NOUN
aiua-13516	193	20	.	.	PUNCT
aiua-13516	194	1	first	first	ADV
aiua-13516	194	2	and	and	CCONJ
aiua-13516	194	3	foremost	foremost	ADV
aiua-13516	194	4	,	,	PUNCT
aiua-13516	194	5	as	as	SCONJ
aiua-13516	194	6	research	research	NOUN
aiua-13516	194	7	in	in	ADP
aiua-13516	194	8	the	the	DET
aiua-13516	194	9	protein	protein	NOUN
aiua-13516	194	10	lactylation	lactylation	NOUN
aiua-13516	194	11	field	field	NOUN
aiua-13516	194	12	is	be	AUX
aiua-13516	194	13	still	still	ADV
aiua-13516	194	14	in	in	ADP
aiua-13516	194	15	its	its	PRON
aiua-13516	194	16	preliminary	preliminary	ADJ
aiua-13516	194	17	stages	stage	NOUN
aiua-13516	194	18	,	,	PUNCT
aiua-13516	194	19	there	there	PRON
aiua-13516	194	20	are	be	VERB
aiua-13516	194	21	relatively	relatively	ADV
aiua-13516	194	22	few	few	ADJ
aiua-13516	194	23	genes	gene	NOUN
aiua-13516	194	24	directly	directly	ADV
aiua-13516	194	25	related	relate	VERB
aiua-13516	194	26	to	to	ADP
aiua-13516	194	27	lactylation	lactylation	NOUN
aiua-13516	194	28	modification	modification	NOUN
aiua-13516	194	29	reported	report	VERB
aiua-13516	194	30	.	.	PUNCT
aiua-13516	195	1	therefore	therefore	ADV
aiua-13516	195	2	,	,	PUNCT
aiua-13516	195	3	the	the	DET
aiua-13516	195	4	lactylation	lactylation	NOUN
aiua-13516	195	5	gene	gene	NOUN
aiua-13516	195	6	subtypes	subtype	NOUN
aiua-13516	195	7	and	and	CCONJ
aiua-13516	195	8	lactylation	lactylation	NOUN
aiua-13516	195	9	score	score	NOUN
aiua-13516	195	10	identified	identify	VERB
aiua-13516	195	11	based	base	VERB
aiua-13516	195	12	on	on	ADP
aiua-13516	195	13	these	these	DET
aiua-13516	195	14	genes	gene	NOUN
aiua-13516	195	15	may	may	AUX
aiua-13516	195	16	not	not	PART
aiua-13516	195	17	be	be	AUX
aiua-13516	195	18	able	able	ADJ
aiua-13516	195	19	to	to	PART
aiua-13516	195	20	fully	fully	ADV
aiua-13516	195	21	describe	describe	VERB
aiua-13516	195	22	the	the	DET
aiua-13516	195	23	characteristics	characteristic	NOUN
aiua-13516	195	24	of	of	ADP
aiua-13516	195	25	lactylationrelated	lactylationrelate	VERB
aiua-13516	195	26	gene	gene	NOUN
aiua-13516	195	27	signature	signature	NOUN
aiua-13516	195	28	.	.	PUNCT
aiua-13516	196	1	furthermore	furthermore	ADV
aiua-13516	196	2	,	,	PUNCT
aiua-13516	196	3	the	the	DET
aiua-13516	196	4	experimental	experimental	ADJ
aiua-13516	196	5	validation	validation	NOUN
aiua-13516	196	6	of	of	ADP
aiua-13516	196	7	all	all	DET
aiua-13516	196	8	signature	signature	NOUN
aiua-13516	196	9	genes	gene	NOUN
aiua-13516	196	10	currently	currently	ADV
aiua-13516	196	11	faces	face	VERB
aiua-13516	196	12	practical	practical	ADJ
aiua-13516	196	13	difficulty	difficulty	NOUN
aiua-13516	196	14	due	due	ADP
aiua-13516	196	15	to	to	ADP
aiua-13516	196	16	the	the	DET
aiua-13516	196	17	lack	lack	NOUN
aiua-13516	196	18	of	of	ADP
aiua-13516	196	19	corresponding	correspond	VERB
aiua-13516	196	20	lactylation	lactylation	NOUN
aiua-13516	196	21	antibodies	antibodie	VERB
aiua-13516	196	22	.	.	PUNCT
aiua-13516	197	1	another	another	DET
aiua-13516	197	2	potential	potential	ADJ
aiua-13516	197	3	limitation	limitation	NOUN
aiua-13516	197	4	of	of	ADP
aiua-13516	197	5	this	this	DET
aiua-13516	197	6	study	study	NOUN
aiua-13516	197	7	is	be	AUX
aiua-13516	197	8	that	that	SCONJ
aiua-13516	197	9	the	the	DET
aiua-13516	197	10	findings	finding	NOUN
aiua-13516	197	11	of	of	ADP
aiua-13516	197	12	this	this	DET
aiua-13516	197	13	study	study	NOUN
aiua-13516	197	14	rely	rely	VERB
aiua-13516	197	15	mainly	mainly	ADV
aiua-13516	197	16	on	on	ADP
aiua-13516	197	17	retrospective	retrospective	ADJ
aiua-13516	197	18	data	datum	NOUN
aiua-13516	197	19	collected	collect	VERB
aiua-13516	197	20	from	from	ADP
aiua-13516	197	21	public	public	ADJ
aiua-13516	197	22	databases	database	NOUN
aiua-13516	197	23	.	.	PUNCT
aiua-13516	198	1	the	the	DET
aiua-13516	198	2	accuracy	accuracy	NOUN
aiua-13516	198	3	of	of	ADP
aiua-13516	198	4	the	the	DET
aiua-13516	198	5	lactylation	lactylation	NOUN
aiua-13516	198	6	score	score	NOUN
aiua-13516	198	7	in	in	ADP
aiua-13516	198	8	predicting	predict	VERB
aiua-13516	198	9	the	the	DET
aiua-13516	198	10	response	response	NOUN
aiua-13516	198	11	to	to	ADP
aiua-13516	198	12	ici	ici	NOUN
aiua-13516	198	13	treatment	treatment	NOUN
aiua-13516	198	14	by	by	ADP
aiua-13516	198	15	bca	bca	PROPN
aiua-13516	198	16	still	still	ADV
aiua-13516	198	17	needs	need	VERB
aiua-13516	198	18	to	to	PART
aiua-13516	198	19	be	be	AUX
aiua-13516	198	20	verified	verify	VERB
aiua-13516	198	21	by	by	ADP
aiua-13516	198	22	large	large	ADJ
aiua-13516	198	23	-	-	PUNCT
aiua-13516	198	24	scale	scale	NOUN
aiua-13516	198	25	clinical	clinical	ADJ
aiua-13516	198	26	trials	trial	NOUN
aiua-13516	198	27	.	.	PUNCT
aiua-13516	199	1	conclusions	conclusion	NOUN
aiua-13516	199	2	in	in	ADP
aiua-13516	199	3	the	the	DET
aiua-13516	199	4	light	light	NOUN
aiua-13516	199	5	of	of	ADP
aiua-13516	199	6	our	our	PRON
aiua-13516	199	7	findings	finding	NOUN
aiua-13516	199	8	and	and	CCONJ
aiua-13516	199	9	the	the	DET
aiua-13516	199	10	limited	limited	ADJ
aiua-13516	199	11	data	datum	NOUN
aiua-13516	199	12	published	publish	VERB
aiua-13516	199	13	so	so	ADV
aiua-13516	199	14	far	far	ADV
aiua-13516	199	15	in	in	ADP
aiua-13516	199	16	the	the	DET
aiua-13516	199	17	literature	literature	NOUN
aiua-13516	199	18	,	,	PUNCT
aiua-13516	199	19	we	we	PRON
aiua-13516	199	20	may	may	AUX
aiua-13516	199	21	state	state	VERB
aiua-13516	199	22	that	that	SCONJ
aiua-13516	199	23	lactylation	lactylation	NOUN
aiua-13516	199	24	genes	gene	NOUN
aiua-13516	199	25	have	have	VERB
aiua-13516	199	26	a	a	DET
aiua-13516	199	27	significant	significant	ADJ
aiua-13516	199	28	control	control	NOUN
aiua-13516	199	29	over	over	ADP
aiua-13516	199	30	the	the	DET
aiua-13516	199	31	immune	immune	ADJ
aiua-13516	199	32	microenvironment	microenvironment	NOUN
aiua-13516	199	33	of	of	ADP
aiua-13516	199	34	tumors	tumor	NOUN
aiua-13516	199	35	,	,	PUNCT
aiua-13516	199	36	clinical	clinical	ADJ
aiua-13516	199	37	traits	trait	NOUN
aiua-13516	199	38	and	and	CCONJ
aiua-13516	199	39	treatment	treatment	NOUN
aiua-13516	199	40	outcomes	outcome	NOUN
aiua-13516	199	41	in	in	ADP
aiua-13516	199	42	cases	case	NOUN
aiua-13516	199	43	with	with	ADP
aiua-13516	199	44	blca	blca	PROPN
aiua-13516	199	45	.	.	PUNCT
aiua-13516	200	1	moreover	moreover	ADV
aiua-13516	200	2	,	,	PUNCT
aiua-13516	200	3	a	a	DET
aiua-13516	200	4	lactylation	lactylation	NOUN
aiua-13516	200	5	score	score	NOUN
aiua-13516	200	6	has	have	AUX
aiua-13516	200	7	been	be	AUX
aiua-13516	200	8	well	well	ADV
aiua-13516	200	9	established	establish	VERB
aiua-13516	200	10	by	by	ADP
aiua-13516	200	11	our	our	PRON
aiua-13516	200	12	group	group	NOUN
aiua-13516	200	13	and	and	CCONJ
aiua-13516	200	14	this	this	DET
aiua-13516	200	15	scoring	scoring	NOUN
aiua-13516	200	16	has	have	AUX
aiua-13516	200	17	proven	prove	VERB
aiua-13516	200	18	its	its	PRON
aiua-13516	200	19	reliability	reliability	NOUN
aiua-13516	200	20	in	in	ADP
aiua-13516	200	21	the	the	DET
aiua-13516	200	22	prediction	prediction	NOUN
aiua-13516	200	23	of	of	ADP
aiua-13516	200	24	the	the	DET
aiua-13516	200	25	prognosis	prognosis	NOUN
aiua-13516	200	26	and	and	CCONJ
aiua-13516	200	27	efficacy	efficacy	NOUN
aiua-13516	200	28	of	of	ADP
aiua-13516	200	29	ici	ici	PROPN
aiua-13516	200	30	treatment	treatment	NOUN
aiua-13516	200	31	.	.	PUNCT
aiua-13516	201	1	all	all	DET
aiua-13516	201	2	these	these	DET
aiua-13516	201	3	observations	observation	NOUN
aiua-13516	201	4	indicated	indicate	VERB
aiua-13516	201	5	well	well	ADV
aiua-13516	201	6	the	the	DET
aiua-13516	201	7	vital	vital	ADJ
aiua-13516	201	8	role	role	NOUN
aiua-13516	201	9	of	of	ADP
aiua-13516	201	10	lactylation	lactylation	NOUN
aiua-13516	201	11	in	in	ADP
aiua-13516	201	12	clinical	clinical	ADJ
aiua-13516	201	13	practice	practice	NOUN
aiua-13516	201	14	which	which	PRON
aiua-13516	201	15	could	could	AUX
aiua-13516	201	16	enable	enable	VERB
aiua-13516	201	17	the	the	DET
aiua-13516	201	18	physicians	physician	NOUN
aiua-13516	201	19	to	to	ADP
aiua-13516	201	20	potential	potential	ADJ
aiua-13516	201	21	customization	customization	NOUN
aiua-13516	201	22	of	of	ADP
aiua-13516	201	23	the	the	DET
aiua-13516	201	24	applied	apply	VERB
aiua-13516	201	25	treatments	treatment	NOUN
aiua-13516	201	26	in	in	ADP
aiua-13516	201	27	blca	blca	ADJ
aiua-13516	201	28	patients	patient	NOUN
aiua-13516	201	29	.	.	PUNCT
aiua-13516	202	1	references	reference	NOUN
aiua-13516	202	2	1	1	NUM
aiua-13516	202	3	.	.	PUNCT
aiua-13516	202	4	sung	sung	PROPN
aiua-13516	202	5	h	h	NOUN
aiua-13516	202	6	,	,	PUNCT
aiua-13516	202	7	ferlay	ferlay	PROPN
aiua-13516	202	8	j	j	PROPN
aiua-13516	202	9	,	,	PUNCT
aiua-13516	202	10	siegel	siegel	PROPN
aiua-13516	202	11	rl	rl	PROPN
aiua-13516	202	12	,	,	PUNCT
aiua-13516	202	13	et	et	PROPN
aiua-13516	202	14	al	al	PROPN
aiua-13516	202	15	.	.	PUNCT
aiua-13516	203	1	global	global	ADJ
aiua-13516	203	2	cancer	cancer	NOUN
aiua-13516	203	3	statistics	statistic	NOUN
aiua-13516	203	4	2020	2020	NUM
aiua-13516	203	5	:	:	PUNCT
aiua-13516	203	6	globocan	globocan	PROPN
aiua-13516	203	7	estimates	estimate	NOUN
aiua-13516	203	8	of	of	ADP
aiua-13516	203	9	incidence	incidence	NOUN
aiua-13516	203	10	and	and	CCONJ
aiua-13516	203	11	mortality	mortality	NOUN
aiua-13516	203	12	worldwide	worldwide	ADV
aiua-13516	203	13	for	for	ADP
aiua-13516	203	14	36	36	NUM
aiua-13516	203	15	cancers	cancer	NOUN
aiua-13516	203	16	in	in	ADP
aiua-13516	203	17	185	185	NUM
aiua-13516	203	18	countries	country	NOUN
aiua-13516	203	19	.	.	PUNCT
aiua-13516	204	1	ca	can	AUX
aiua-13516	204	2	cancer	cancer	PROPN
aiua-13516	204	3	j	j	PROPN
aiua-13516	204	4	clin	clin	PROPN
aiua-13516	204	5	.	.	PUNCT
aiua-13516	205	1	2021	2021	NUM
aiua-13516	205	2	;	;	PUNCT
aiua-13516	205	3	71:209	71:209	NUM
aiua-13516	205	4	-	-	SYM
aiua-13516	205	5	49	49	NUM
aiua-13516	205	6	.	.	PUNCT
aiua-13516	206	1	2	2	X
aiua-13516	206	2	.	.	X
aiua-13516	206	3	lobo	lobo	PROPN
aiua-13516	206	4	n	n	CCONJ
aiua-13516	206	5	,	,	PUNCT
aiua-13516	206	6	afferi	afferi	PROPN
aiua-13516	206	7	l	l	PROPN
aiua-13516	206	8	,	,	PUNCT
aiua-13516	206	9	moschini	moschini	PROPN
aiua-13516	206	10	m	m	PROPN
aiua-13516	206	11	,	,	PUNCT
aiua-13516	206	12	et	et	PROPN
aiua-13516	206	13	al	al	PROPN
aiua-13516	206	14	.	.	PUNCT
aiua-13516	207	1	epidemiology	epidemiology	NOUN
aiua-13516	207	2	,	,	PUNCT
aiua-13516	207	3	screening	screening	NOUN
aiua-13516	207	4	,	,	PUNCT
aiua-13516	207	5	and	and	CCONJ
aiua-13516	207	6	prevention	prevention	NOUN
aiua-13516	207	7	of	of	ADP
aiua-13516	207	8	bladder	bladder	NOUN
aiua-13516	207	9	cancer	cancer	NOUN
aiua-13516	207	10	.	.	PUNCT
aiua-13516	208	1	eur	eur	PROPN
aiua-13516	208	2	urol	urol	PROPN
aiua-13516	208	3	oncol	oncol	PROPN
aiua-13516	208	4	.	.	PUNCT
aiua-13516	209	1	2022	2022	NUM
aiua-13516	209	2	;	;	PUNCT
aiua-13516	209	3	5:628	5:628	NUM
aiua-13516	209	4	-	-	SYM
aiua-13516	209	5	39	39	NUM
aiua-13516	209	6	.	.	PUNCT
aiua-13516	210	1	3	3	X
aiua-13516	210	2	.	.	X
aiua-13516	211	1	chen	chen	PROPN
aiua-13516	211	2	x	x	PROPN
aiua-13516	211	3	,	,	PUNCT
aiua-13516	211	4	zhang	zhang	PROPN
aiua-13516	211	5	j	j	PROPN
aiua-13516	211	6	,	,	PUNCT
aiua-13516	211	7	ruan	ruan	PROPN
aiua-13516	211	8	w	w	PROPN
aiua-13516	211	9	,	,	PUNCT
aiua-13516	211	10	et	et	PROPN
aiua-13516	211	11	al	al	PROPN
aiua-13516	211	12	.	.	PROPN
aiua-13516	211	13	urine	urine	PROPN
aiua-13516	211	14	dna	dna	PROPN
aiua-13516	211	15	methylation	methylation	NOUN
aiua-13516	211	16	assay	assay	NOUN
aiua-13516	211	17	enables	enable	VERB
aiua-13516	211	18	early	early	ADJ
aiua-13516	211	19	detection	detection	NOUN
aiua-13516	211	20	and	and	CCONJ
aiua-13516	211	21	recurrence	recurrence	NOUN
aiua-13516	211	22	monitoring	monitoring	NOUN
aiua-13516	211	23	for	for	ADP
aiua-13516	211	24	bladder	bladder	NOUN
aiua-13516	211	25	cancer	cancer	NOUN
aiua-13516	211	26	.	.	PUNCT
aiua-13516	212	1	j	j	PROPN
aiua-13516	212	2	clin	clin	PROPN
aiua-13516	212	3	invest	invest	PROPN
aiua-13516	212	4	.	.	PUNCT
aiua-13516	213	1	2020	2020	NUM
aiua-13516	213	2	;	;	PUNCT
aiua-13516	213	3	130:6278	130:6278	NUM
aiua-13516	213	4	-	-	SYM
aiua-13516	213	5	89	89	NUM
aiua-13516	213	6	.	.	PUNCT
aiua-13516	214	1	4	4	NUM
aiua-13516	214	2	.	.	NOUN
aiua-13516	214	3	bellmunt	bellmunt	PROPN
aiua-13516	214	4	j	j	PROPN
aiua-13516	214	5	,	,	PUNCT
aiua-13516	214	6	powles	powle	VERB
aiua-13516	214	7	t	t	PROPN
aiua-13516	214	8	,	,	PUNCT
aiua-13516	214	9	vogelzang	vogelzang	PROPN
aiua-13516	214	10	nj	nj	PROPN
aiua-13516	214	11	.	.	PUNCT
aiua-13516	215	1	a	a	DET
aiua-13516	215	2	review	review	NOUN
aiua-13516	215	3	on	on	ADP
aiua-13516	215	4	the	the	DET
aiua-13516	215	5	evolution	evolution	NOUN
aiua-13516	215	6	of	of	ADP
aiua-13516	215	7	pd-1	pd-1	ADP
aiua-13516	215	8	/	/	SYM
aiua-13516	215	9	pd	pd	ADJ
aiua-13516	215	10	-	-	PROPN
aiua-13516	215	11	l1	l1	PROPN
aiua-13516	215	12	immunotherapy	immunotherapy	NOUN
aiua-13516	215	13	for	for	ADP
aiua-13516	215	14	bladder	bladder	NOUN
aiua-13516	215	15	cancer	cancer	NOUN
aiua-13516	215	16	:	:	PUNCT
aiua-13516	215	17	the	the	DET
aiua-13516	215	18	future	future	NOUN
aiua-13516	215	19	is	be	AUX
aiua-13516	215	20	now	now	ADV
aiua-13516	215	21	.	.	PUNCT
aiua-13516	216	1	cancer	cancer	NOUN
aiua-13516	216	2	treat	treat	PROPN
aiua-13516	216	3	rev	rev	VERB
aiua-13516	216	4	.	.	PROPN
aiua-13516	216	5	2017	2017	NUM
aiua-13516	216	6	;	;	PUNCT
aiua-13516	216	7	54:58	54:58	NUM
aiua-13516	216	8	-	-	SYM
aiua-13516	216	9	67	67	NUM
aiua-13516	216	10	.	.	PUNCT
aiua-13516	217	1	5	5	NUM
aiua-13516	217	2	.	.	X
aiua-13516	217	3	boegemann	boegemann	PROPN
aiua-13516	217	4	m	m	PROPN
aiua-13516	217	5	,	,	PUNCT
aiua-13516	217	6	aydin	aydin	NOUN
aiua-13516	217	7	am	be	AUX
aiua-13516	217	8	,	,	PUNCT
aiua-13516	217	9	bagrodia	bagrodia	PROPN
aiua-13516	217	10	a	a	PROPN
aiua-13516	217	11	,	,	PUNCT
aiua-13516	217	12	krabbe	krabbe	NOUN
aiua-13516	217	13	lm	lm	PROPN
aiua-13516	217	14	.	.	PUNCT
aiua-13516	217	15	prospects	prospect	NOUN
aiua-13516	217	16	and	and	CCONJ
aiua-13516	217	17	progress	progress	NOUN
aiua-13516	217	18	of	of	ADP
aiua-13516	217	19	immunotherapy	immunotherapy	NOUN
aiua-13516	217	20	for	for	ADP
aiua-13516	217	21	bladder	bladder	NOUN
aiua-13516	217	22	cancer	cancer	NOUN
aiua-13516	217	23	.	.	PUNCT
aiua-13516	218	1	expert	expert	NOUN
aiua-13516	218	2	opin	opin	NOUN
aiua-13516	218	3	biol	biol	NOUN
aiua-13516	218	4	ther	ther	ADV
aiua-13516	218	5	.	.	PUNCT
aiua-13516	219	1	2017	2017	NUM
aiua-13516	219	2	;	;	PUNCT
aiua-13516	219	3	17:1417	17:1417	NUM
aiua-13516	219	4	-	-	SYM
aiua-13516	219	5	31	31	NUM
aiua-13516	219	6	.	.	PUNCT
aiua-13516	220	1	6	6	NUM
aiua-13516	220	2	.	.	X
aiua-13516	221	1	zhang	zhang	PROPN
aiua-13516	221	2	d	d	PROPN
aiua-13516	221	3	,	,	PUNCT
aiua-13516	221	4	tang	tang	PROPN
aiua-13516	221	5	z	z	PROPN
aiua-13516	221	6	,	,	PUNCT
aiua-13516	221	7	huang	huang	PROPN
aiua-13516	221	8	h	h	PROPN
aiua-13516	221	9	,	,	PUNCT
aiua-13516	221	10	et	et	PROPN
aiua-13516	221	11	al	al	PROPN
aiua-13516	221	12	.	.	PROPN
aiua-13516	221	13	metabolic	metabolic	PROPN
aiua-13516	221	14	regulation	regulation	NOUN
aiua-13516	221	15	of	of	ADP
aiua-13516	221	16	gene	gene	NOUN
aiua-13516	221	17	expression	expression	NOUN
aiua-13516	221	18	by	by	ADP
aiua-13516	221	19	histone	histone	NOUN
aiua-13516	221	20	lactylation	lactylation	NOUN
aiua-13516	221	21	.	.	PUNCT
aiua-13516	222	1	nature	nature	NOUN
aiua-13516	222	2	.	.	PUNCT
aiua-13516	223	1	2019	2019	NUM
aiua-13516	223	2	;	;	PUNCT
aiua-13516	223	3	574:575	574:575	NOUN
aiua-13516	223	4	-	-	PUNCT
aiua-13516	223	5	80	80	NUM
aiua-13516	223	6	.	.	PUNCT
aiua-13516	224	1	7	7	X
aiua-13516	224	2	.	.	X
aiua-13516	224	3	fan	fan	PROPN
aiua-13516	224	4	h	h	PROPN
aiua-13516	224	5	,	,	PUNCT
aiua-13516	224	6	yang	yang	PROPN
aiua-13516	224	7	f	f	PROPN
aiua-13516	224	8	,	,	PUNCT
aiua-13516	224	9	xiao	xiao	PROPN
aiua-13516	224	10	z	z	PROPN
aiua-13516	224	11	,	,	PUNCT
aiua-13516	225	1	et	et	PROPN
aiua-13516	225	2	al	al	PROPN
aiua-13516	225	3	.	.	PROPN
aiua-13516	225	4	lactylation	lactylation	PROPN
aiua-13516	225	5	:	:	PUNCT
aiua-13516	225	6	novel	novel	ADJ
aiua-13516	225	7	epigenetic	epigenetic	ADJ
aiua-13516	225	8	regulatory	regulatory	ADJ
aiua-13516	225	9	and	and	CCONJ
aiua-13516	225	10	therapeutic	therapeutic	ADJ
aiua-13516	225	11	opportunities	opportunity	NOUN
aiua-13516	225	12	.	.	PUNCT
aiua-13516	226	1	am	be	AUX
aiua-13516	226	2	j	j	PROPN
aiua-13516	226	3	physiol	physiol	PROPN
aiua-13516	226	4	endocrinol	endocrinol	NOUN
aiua-13516	226	5	metab	metab	NOUN
aiua-13516	226	6	.	.	PUNCT
aiua-13516	227	1	2023	2023	NUM
aiua-13516	227	2	;	;	PUNCT
aiua-13516	227	3	324	324	NUM
aiua-13516	227	4	:	:	PUNCT
aiua-13516	227	5	e330	e330	PROPN
aiua-13516	227	6	-	-	SYM
aiua-13516	227	7	8	8	NUM
aiua-13516	227	8	.	.	NOUN
aiua-13516	227	9	8	8	NUM
aiua-13516	227	10	.	.	PUNCT
aiua-13516	228	1	rong	rong	PROPN
aiua-13516	228	2	y	y	PROPN
aiua-13516	228	3	,	,	PUNCT
aiua-13516	228	4	dong	dong	PROPN
aiua-13516	228	5	f	f	PROPN
aiua-13516	228	6	,	,	PUNCT
aiua-13516	228	7	zhang	zhang	PROPN
aiua-13516	228	8	g	g	PROPN
aiua-13516	228	9	,	,	PUNCT
aiua-13516	228	10	et	et	PROPN
aiua-13516	228	11	al	al	PROPN
aiua-13516	228	12	.	.	PUNCT
aiua-13516	229	1	the	the	DET
aiua-13516	229	2	crosstalking	crosstalking	NOUN
aiua-13516	229	3	of	of	ADP
aiua-13516	229	4	lactatehistone	lactatehistone	ADJ
aiua-13516	229	5	lactylation	lactylation	NOUN
aiua-13516	229	6	and	and	CCONJ
aiua-13516	229	7	tumor	tumor	NOUN
aiua-13516	229	8	.	.	PUNCT
aiua-13516	230	1	proteomics	proteomic	NOUN
aiua-13516	230	2	clin	clin	PROPN
aiua-13516	230	3	appl	appl	PROPN
aiua-13516	231	1	.	.	PUNCT
aiua-13516	231	2	2023	2023	NUM
aiua-13516	231	3	;	;	PUNCT
aiua-13516	232	1	17	17	NUM
aiua-13516	232	2	:	:	PUNCT
aiua-13516	232	3	e2200102	e2200102	NOUN
aiua-13516	232	4	.	.	NOUN
aiua-13516	232	5	9	9	NUM
aiua-13516	232	6	.	.	X
aiua-13516	232	7	pérez	pérez	NOUN
aiua-13516	232	8	-	-	PUNCT
aiua-13516	232	9	tomás	tomás	NOUN
aiua-13516	232	10	r	r	NOUN
aiua-13516	232	11	,	,	PUNCT
aiua-13516	232	12	pérez	pérez	NOUN
aiua-13516	232	13	-	-	PUNCT
aiua-13516	232	14	guillén	guillén	NOUN
aiua-13516	232	15	i.	i.	NOUN
aiua-13516	232	16	lactate	lactate	PROPN
aiua-13516	232	17	in	in	ADP
aiua-13516	232	18	the	the	DET
aiua-13516	232	19	tumor	tumor	NOUN
aiua-13516	232	20	microenvironment	microenvironment	NOUN
aiua-13516	232	21	:	:	PUNCT
aiua-13516	232	22	an	an	DET
aiua-13516	232	23	essential	essential	ADJ
aiua-13516	232	24	molecule	molecule	NOUN
aiua-13516	232	25	in	in	ADP
aiua-13516	232	26	cancer	cancer	NOUN
aiua-13516	232	27	progression	progression	NOUN
aiua-13516	232	28	and	and	CCONJ
aiua-13516	232	29	treatment	treatment	NOUN
aiua-13516	232	30	.	.	PUNCT
aiua-13516	233	1	cancers	cancer	NOUN
aiua-13516	233	2	(	(	PUNCT
aiua-13516	233	3	basel	basel	PROPN
aiua-13516	233	4	)	)	PUNCT
aiua-13516	233	5	.	.	PUNCT
aiua-13516	234	1	2020	2020	NUM
aiua-13516	234	2	;	;	PUNCT
aiua-13516	235	1	12:3244	12:3244	NUM
aiua-13516	235	2	.	.	PROPN
aiua-13516	235	3	10	10	NUM
aiua-13516	235	4	.	.	PUNCT
aiua-13516	236	1	ippolito	ippolito	PROPN
aiua-13516	236	2	l	l	PROPN
aiua-13516	236	3	,	,	PUNCT
aiua-13516	236	4	morandi	morandi	PROPN
aiua-13516	236	5	a	a	PROPN
aiua-13516	236	6	,	,	PUNCT
aiua-13516	236	7	giannoni	giannoni	PROPN
aiua-13516	236	8	e	e	NOUN
aiua-13516	236	9	,	,	PUNCT
aiua-13516	236	10	chiarugi	chiarugi	PROPN
aiua-13516	236	11	p.	p.	NOUN
aiua-13516	236	12	lactate	lactate	PROPN
aiua-13516	236	13	:	:	PUNCT
aiua-13516	236	14	a	a	DET
aiua-13516	236	15	metabolic	metabolic	NOUN
aiua-13516	236	16	driver	driver	NOUN
aiua-13516	236	17	in	in	ADP
aiua-13516	236	18	the	the	DET
aiua-13516	236	19	tumour	tumour	NOUN
aiua-13516	236	20	landscape	landscape	NOUN
aiua-13516	236	21	.	.	PUNCT
aiua-13516	237	1	trends	trend	NOUN
aiua-13516	237	2	biochem	biochem	PROPN
aiua-13516	237	3	sci	sci	PROPN
aiua-13516	237	4	.	.	PROPN
aiua-13516	237	5	2019	2019	NUM
aiua-13516	237	6	;	;	PUNCT
aiua-13516	237	7	44:153	44:153	NUM
aiua-13516	237	8	-	-	SYM
aiua-13516	237	9	66	66	NUM
aiua-13516	237	10	.	.	PUNCT
aiua-13516	238	1	11	11	NUM
aiua-13516	238	2	.	.	X
aiua-13516	239	1	certo	certo	PROPN
aiua-13516	239	2	m	m	PROPN
aiua-13516	239	3	,	,	PUNCT
aiua-13516	239	4	tsai	tsai	PROPN
aiua-13516	239	5	ch	ch	PROPN
aiua-13516	239	6	,	,	PUNCT
aiua-13516	239	7	pucino	pucino	PROPN
aiua-13516	239	8	v	v	PROPN
aiua-13516	239	9	,	,	PUNCT
aiua-13516	239	10	et	et	PROPN
aiua-13516	239	11	al	al	PROPN
aiua-13516	239	12	.	.	PUNCT
aiua-13516	239	13	lactate	lactate	PROPN
aiua-13516	239	14	modulation	modulation	NOUN
aiua-13516	239	15	of	of	ADP
aiua-13516	239	16	immune	immune	ADJ
aiua-13516	239	17	responses	response	NOUN
aiua-13516	239	18	in	in	ADP
aiua-13516	239	19	inflammatory	inflammatory	ADJ
aiua-13516	239	20	versus	versus	ADP
aiua-13516	239	21	tumour	tumour	ADJ
aiua-13516	239	22	microenvironments	microenvironment	NOUN
aiua-13516	239	23	.	.	PUNCT
aiua-13516	240	1	nat	nat	PROPN
aiua-13516	240	2	rev	rev	PROPN
aiua-13516	240	3	immunol	immunol	NOUN
aiua-13516	240	4	.	.	PUNCT
aiua-13516	240	5	2021	2021	NUM
aiua-13516	240	6	;	;	PUNCT
aiua-13516	240	7	21:151	21:151	NUM
aiua-13516	240	8	-	-	SYM
aiua-13516	240	9	61	61	NUM
aiua-13516	240	10	.	.	PUNCT
aiua-13516	240	11	12	12	NUM
aiua-13516	240	12	.	.	PUNCT
aiua-13516	241	1	xie	xie	PROPN
aiua-13516	241	2	j	j	PROPN
aiua-13516	241	3	,	,	PUNCT
aiua-13516	241	4	hong	hong	PROPN
aiua-13516	241	5	s	s	PROPN
aiua-13516	241	6	,	,	PUNCT
aiua-13516	241	7	zhang	zhang	PROPN
aiua-13516	241	8	x	x	PROPN
aiua-13516	241	9	,	,	PUNCT
aiua-13516	241	10	et	et	PROPN
aiua-13516	241	11	al	al	PROPN
aiua-13516	241	12	.	.	PROPN
aiua-13516	241	13	inhibition	inhibition	NOUN
aiua-13516	241	14	of	of	ADP
aiua-13516	241	15	glycolysis	glycolysis	NOUN
aiua-13516	241	16	prevents	prevent	VERB
aiua-13516	241	17	behavioural	behavioural	ADJ
aiua-13516	241	18	changes	change	NOUN
aiua-13516	241	19	in	in	ADP
aiua-13516	241	20	mice	mouse	NOUN
aiua-13516	241	21	with	with	ADP
aiua-13516	241	22	mk801	mk801	ADV
aiua-13516	241	23	-	-	PUNCT
aiua-13516	241	24	induced	induce	VERB
aiua-13516	241	25	scz	scz	PROPN
aiua-13516	241	26	model	model	NOUN
aiua-13516	241	27	by	by	ADP
aiua-13516	241	28	alleviating	alleviate	VERB
aiua-13516	241	29	lactate	lactate	NOUN
aiua-13516	241	30	accumulation	accumulation	NOUN
aiua-13516	241	31	and	and	CCONJ
aiua-13516	241	32	lactylation	lactylation	NOUN
aiua-13516	241	33	.	.	PUNCT
aiua-13516	242	1	brain	brain	NOUN
aiua-13516	242	2	res	re	NOUN
aiua-13516	242	3	.	.	PUNCT
aiua-13516	242	4	2023	2023	NUM
aiua-13516	242	5	;	;	PUNCT
aiua-13516	242	6	1812:148409	1812:148409	NUM
aiua-13516	242	7	.	.	NOUN
aiua-13516	242	8	13	13	NUM
aiua-13516	242	9	.	.	X
aiua-13516	243	1	gaffney	gaffney	PROPN
aiua-13516	243	2	do	do	VERB
aiua-13516	243	3	,	,	PUNCT
aiua-13516	243	4	jennings	jennings	PROPN
aiua-13516	243	5	eq	eq	PROPN
aiua-13516	243	6	,	,	PUNCT
aiua-13516	243	7	anderson	anderson	PROPN
aiua-13516	243	8	cc	cc	PROPN
aiua-13516	243	9	,	,	PUNCT
aiua-13516	243	10	et	et	PROPN
aiua-13516	243	11	al	al	PROPN
aiua-13516	243	12	.	.	PUNCT
aiua-13516	244	1	non	non	ADJ
aiua-13516	244	2	-	-	ADJ
aiua-13516	244	3	enzymatic	enzymatic	ADJ
aiua-13516	244	4	lysine	lysine	NOUN
aiua-13516	244	5	lactoylation	lactoylation	NOUN
aiua-13516	244	6	of	of	ADP
aiua-13516	244	7	glycolytic	glycolytic	ADJ
aiua-13516	244	8	enzymes	enzyme	NOUN
aiua-13516	244	9	.	.	PUNCT
aiua-13516	245	1	cell	cell	NOUN
aiua-13516	245	2	chem	chem	NOUN
aiua-13516	245	3	biol	biol	NOUN
aiua-13516	245	4	.	.	PUNCT
aiua-13516	246	1	2020	2020	NUM
aiua-13516	246	2	;	;	PUNCT
aiua-13516	246	3	27:206	27:206	NUM
aiua-13516	246	4	-	-	SYM
aiua-13516	246	5	13.e6	13.e6	NUM
aiua-13516	246	6	.	.	PUNCT
aiua-13516	247	1	14	14	NUM
aiua-13516	247	2	.	.	PUNCT
aiua-13516	248	1	liu	liu	PROPN
aiua-13516	248	2	j	j	PROPN
aiua-13516	248	3	,	,	PUNCT
aiua-13516	248	4	du	du	PROPN
aiua-13516	248	5	j	j	PROPN
aiua-13516	248	6	,	,	PUNCT
aiua-13516	248	7	li	li	PROPN
aiua-13516	248	8	y	y	PROPN
aiua-13516	248	9	,	,	PUNCT
aiua-13516	248	10	et	et	PROPN
aiua-13516	248	11	al	al	PROPN
aiua-13516	248	12	.	.	PUNCT
aiua-13516	248	13	catalpol	catalpol	PROPN
aiua-13516	248	14	induces	induce	VERB
aiua-13516	248	15	apoptosis	apoptosis	NOUN
aiua-13516	248	16	in	in	ADP
aiua-13516	248	17	breast	breast	NOUN
aiua-13516	248	18	cancer	cancer	NOUN
aiua-13516	248	19	in	in	ADP
aiua-13516	248	20	vitro	vitro	X
aiua-13516	248	21	and	and	CCONJ
aiua-13516	248	22	in	in	ADP
aiua-13516	248	23	vivo	vivo	NOUN
aiua-13516	248	24	:	:	PUNCT
aiua-13516	248	25	involvement	involvement	NOUN
aiua-13516	248	26	of	of	ADP
aiua-13516	248	27	mitochondria	mitochondria	NOUN
aiua-13516	248	28	apoptosis	apoptosis	NOUN
aiua-13516	248	29	pathway	pathway	NOUN
aiua-13516	248	30	and	and	CCONJ
aiua-13516	248	31	post	post	ADJ
aiua-13516	248	32	-	-	ADJ
aiua-13516	248	33	translational	translational	ADJ
aiua-13516	248	34	modifications	modification	NOUN
aiua-13516	248	35	.	.	PUNCT
aiua-13516	249	1	toxicol	toxicol	PROPN
aiua-13516	249	2	appl	appl	PROPN
aiua-13516	249	3	pharmacol	pharmacol	PROPN
aiua-13516	249	4	.	.	PUNCT
aiua-13516	250	1	2022	2022	NUM
aiua-13516	250	2	;	;	PUNCT
aiua-13516	251	1	454:116215	454:116215	X
aiua-13516	251	2	.	.	NOUN
aiua-13516	251	3	15	15	NUM
aiua-13516	251	4	.	.	PUNCT
aiua-13516	252	1	yao	yao	PROPN
aiua-13516	252	2	g	g	PROPN
aiua-13516	252	3	,	,	PUNCT
aiua-13516	252	4	yang	yang	PROPN
aiua-13516	252	5	z.	z.	PROPN
aiua-13516	253	1	glypican-3	glypican-3	PROPN
aiua-13516	253	2	knockdown	knockdown	NOUN
aiua-13516	253	3	inhibits	inhibit	VERB
aiua-13516	253	4	the	the	DET
aiua-13516	253	5	cell	cell	NOUN
aiua-13516	253	6	growth	growth	NOUN
aiua-13516	253	7	,	,	PUNCT
aiua-13516	253	8	stemness	stemness	NOUN
aiua-13516	253	9	,	,	PUNCT
aiua-13516	253	10	and	and	CCONJ
aiua-13516	253	11	glycolysis	glycolysis	NOUN
aiua-13516	253	12	development	development	NOUN
aiua-13516	253	13	of	of	ADP
aiua-13516	253	14	hepatocellular	hepatocellular	ADJ
aiua-13516	253	15	carcinoma	carcinoma	NOUN
aiua-13516	253	16	cells	cell	NOUN
aiua-13516	253	17	under	under	ADP
aiua-13516	253	18	hypoxic	hypoxic	ADJ
aiua-13516	253	19	microenvironment	microenvironment	NOUN
aiua-13516	253	20	through	through	ADP
aiua-13516	253	21	lactylation	lactylation	NOUN
aiua-13516	253	22	.	.	PUNCT
aiua-13516	254	1	arch	arch	PROPN
aiua-13516	254	2	physiol	physiol	PROPN
aiua-13516	254	3	biochem	biochem	PROPN
aiua-13516	254	4	.	.	PUNCT
aiua-13516	255	1	2023	2023	NUM
aiua-13516	255	2	;	;	PUNCT
aiua-13516	255	3	2:1	2:1	NUM
aiua-13516	255	4	-	-	SYM
aiua-13516	255	5	9	9	NUM
aiua-13516	255	6	.	.	NOUN
aiua-13516	255	7	16	16	NUM
aiua-13516	255	8	.	.	PUNCT
aiua-13516	256	1	miao	miao	PROPN
aiua-13516	256	2	z	z	PROPN
aiua-13516	256	3	,	,	PUNCT
aiua-13516	256	4	zhao	zhao	PROPN
aiua-13516	256	5	x	x	PROPN
aiua-13516	256	6	,	,	PUNCT
aiua-13516	256	7	liu	liu	PROPN
aiua-13516	256	8	x.	x.	PROPN
aiua-13516	256	9	hypoxia	hypoxia	PROPN
aiua-13516	256	10	induced	induce	VERB
aiua-13516	256	11	β	β	NOUN
aiua-13516	256	12	-	-	ADJ
aiua-13516	256	13	catenin	catenin	ADJ
aiua-13516	256	14	lactylation	lactylation	NOUN
aiua-13516	256	15	promotes	promote	VERB
aiua-13516	256	16	the	the	DET
aiua-13516	256	17	cell	cell	NOUN
aiua-13516	256	18	proliferation	proliferation	NOUN
aiua-13516	256	19	and	and	CCONJ
aiua-13516	256	20	stemness	stemness	NOUN
aiua-13516	256	21	of	of	ADP
aiua-13516	256	22	colorectal	colorectal	ADJ
aiua-13516	256	23	cancer	cancer	NOUN
aiua-13516	256	24	through	through	ADP
aiua-13516	256	25	the	the	DET
aiua-13516	256	26	wnt	wnt	NOUN
aiua-13516	256	27	signaling	signal	VERB
aiua-13516	256	28	pathway	pathway	NOUN
aiua-13516	256	29	.	.	PUNCT
aiua-13516	257	1	exp	exp	NOUN
aiua-13516	257	2	cell	cell	NOUN
aiua-13516	257	3	res	re	NOUN
aiua-13516	257	4	.	.	PUNCT
aiua-13516	257	5	2023	2023	NUM
aiua-13516	257	6	;	;	PUNCT
aiua-13516	257	7	422:113439	422:113439	X
aiua-13516	257	8	.	.	NOUN
aiua-13516	257	9	17	17	NUM
aiua-13516	257	10	.	.	PUNCT
aiua-13516	258	1	gu	gu	PROPN
aiua-13516	258	2	j	j	PROPN
aiua-13516	258	3	,	,	PUNCT
aiua-13516	258	4	zhou	zhou	PROPN
aiua-13516	258	5	j	j	PROPN
aiua-13516	258	6	,	,	PUNCT
aiua-13516	258	7	chen	chen	PROPN
aiua-13516	259	1	q	q	PROPN
aiua-13516	259	2	,	,	PUNCT
aiua-13516	259	3	et	et	PROPN
aiua-13516	259	4	al	al	PROPN
aiua-13516	259	5	.	.	PROPN
aiua-13516	259	6	tumor	tumor	PROPN
aiua-13516	259	7	metabolite	metabolite	PROPN
aiua-13516	259	8	lactate	lactate	PROPN
aiua-13516	259	9	promotes	promote	VERB
aiua-13516	259	10	tumorigenesis	tumorigenesis	NOUN
aiua-13516	259	11	by	by	ADP
aiua-13516	259	12	modulating	modulate	VERB
aiua-13516	259	13	moesin	moesin	NOUN
aiua-13516	259	14	lactylation	lactylation	NOUN
aiua-13516	259	15	and	and	CCONJ
aiua-13516	259	16	enhancing	enhance	VERB
aiua-13516	259	17	tgf	tgf	PROPN
aiua-13516	259	18	-	-	PUNCT
aiua-13516	259	19	β	β	NOUN
aiua-13516	259	20	signaling	signal	VERB
aiua-13516	259	21	in	in	ADP
aiua-13516	259	22	regulatory	regulatory	ADJ
aiua-13516	259	23	t	t	NOUN
aiua-13516	259	24	cells	cell	NOUN
aiua-13516	259	25	.	.	PUNCT
aiua-13516	260	1	cell	cell	NOUN
aiua-13516	260	2	rep	rep	PROPN
aiua-13516	260	3	.	.	PROPN
aiua-13516	260	4	2022	2022	NUM
aiua-13516	260	5	;	;	PUNCT
aiua-13516	260	6	40:111122	40:111122	NUM
aiua-13516	260	7	.	.	NOUN
aiua-13516	260	8	18	18	NUM
aiua-13516	260	9	.	.	PUNCT
aiua-13516	261	1	liu	liu	PROPN
aiua-13516	261	2	x	x	PROPN
aiua-13516	261	3	,	,	PUNCT
aiua-13516	261	4	zhang	zhang	PROPN
aiua-13516	261	5	y	y	PROPN
aiua-13516	261	6	,	,	PUNCT
aiua-13516	261	7	li	li	PROPN
aiua-13516	261	8	w	w	PROPN
aiua-13516	261	9	,	,	PUNCT
aiua-13516	261	10	zhou	zhou	PROPN
aiua-13516	261	11	x.	x.	PROPN
aiua-13516	261	12	lactylation	lactylation	PROPN
aiua-13516	261	13	,	,	PUNCT
aiua-13516	261	14	an	an	DET
aiua-13516	261	15	emerging	emerge	VERB
aiua-13516	261	16	hallmark	hallmark	NOUN
aiua-13516	261	17	of	of	ADP
aiua-13516	261	18	metabolic	metabolic	NOUN
aiua-13516	261	19	reprogramming	reprogramming	NOUN
aiua-13516	261	20	:	:	PUNCT
aiua-13516	261	21	current	current	ADJ
aiua-13516	261	22	progress	progress	NOUN
aiua-13516	261	23	and	and	CCONJ
aiua-13516	261	24	open	open	ADJ
aiua-13516	261	25	challenges	challenge	NOUN
aiua-13516	261	26	.	.	PUNCT
aiua-13516	262	1	front	front	ADJ
aiua-13516	262	2	cell	cell	NOUN
aiua-13516	262	3	dev	dev	PROPN
aiua-13516	262	4	biol	biol	NOUN
aiua-13516	262	5	.	.	PUNCT
aiua-13516	263	1	2022	2022	NUM
aiua-13516	263	2	;	;	PUNCT
aiua-13516	263	3	10:972020	10:972020	NUM
aiua-13516	263	4	.	.	PROPN
aiua-13516	263	5	19	19	NUM
aiua-13516	263	6	.	.	PUNCT
aiua-13516	264	1	yang	yang	PROPN
aiua-13516	264	2	z	z	PROPN
aiua-13516	264	3	,	,	PUNCT
aiua-13516	264	4	ming	ming	PROPN
aiua-13516	264	5	x	x	PROPN
aiua-13516	264	6	,	,	PUNCT
aiua-13516	264	7	huang	huang	PROPN
aiua-13516	264	8	s	s	PROPN
aiua-13516	264	9	,	,	PUNCT
aiua-13516	264	10	et	et	PROPN
aiua-13516	264	11	al	al	PROPN
aiua-13516	264	12	.	.	PROPN
aiua-13516	264	13	comprehensive	comprehensive	ADJ
aiua-13516	264	14	analysis	analysis	NOUN
aiua-13516	264	15	of	of	ADP
aiua-13516	264	16	m(6)a	m(6)a	ADJ
aiua-13516	264	17	regulators	regulator	NOUN
aiua-13516	264	18	characterized	characterize	VERB
aiua-13516	264	19	by	by	ADP
aiua-13516	264	20	the	the	DET
aiua-13516	264	21	immune	immune	ADJ
aiua-13516	264	22	cell	cell	NOUN
aiua-13516	264	23	infiltration	infiltration	NOUN
aiua-13516	264	24	in	in	ADP
aiua-13516	264	25	head	head	NOUN
aiua-13516	264	26	and	and	CCONJ
aiua-13516	264	27	neck	neck	VERB
aiua-13516	264	28	squamous	squamous	ADJ
aiua-13516	264	29	cell	cell	NOUN
aiua-13516	264	30	carcinoma	carcinoma	NOUN
aiua-13516	264	31	to	to	PART
aiua-13516	264	32	aid	aid	VERB
aiua-13516	264	33	immunotherapy	immunotherapy	NOUN
aiua-13516	264	34	and	and	CCONJ
aiua-13516	264	35	chemotherapy	chemotherapy	NOUN
aiua-13516	264	36	.	.	PUNCT
aiua-13516	265	1	front	front	ADJ
aiua-13516	265	2	oncol	oncol	ADJ
aiua-13516	265	3	.	.	PUNCT
aiua-13516	266	1	2021	2021	NUM
aiua-13516	266	2	;	;	PUNCT
aiua-13516	266	3	11:764798	11:764798	NUM
aiua-13516	266	4	.	.	PUNCT
aiua-13516	267	1	archivio	archivio	NOUN
aiua-13516	267	2	italiano	italiano	PROPN
aiua-13516	267	3	di	di	PROPN
aiua-13516	267	4	urologia	urologia	PROPN
aiua-13516	267	5	e	e	PROPN
aiua-13516	267	6	andrologia	andrologia	NOUN
aiua-13516	267	7	2025	2025	NUM
aiua-13516	267	8	;	;	PUNCT
aiua-13516	267	9	97(1):13516	97(1):13516	NUM
aiua-13516	267	10	g.	g.	PROPN
aiua-13516	267	11	liu	liu	PROPN
aiua-13516	267	12	,	,	PUNCT
aiua-13516	267	13	t.	t.	PROPN
aiua-13516	267	14	hong	hong	PROPN
aiua-13516	267	15	,	,	PUNCT
aiua-13516	267	16	x.	x.	PROPN
aiua-13516	267	17	liu	liu	PROPN
aiua-13516	267	18	,	,	PUNCT
aiua-13516	267	19	et	et	PROPN
aiua-13516	267	20	al	al	PROPN
aiua-13516	267	21	.	.	PROPN
aiua-13516	267	22	12	12	NUM
aiua-13516	267	23	20	20	NUM
aiua-13516	267	24	.	.	PUNCT
aiua-13516	268	1	balar	balar	PROPN
aiua-13516	268	2	av	av	PROPN
aiua-13516	268	3	,	,	PUNCT
aiua-13516	268	4	galsky	galsky	PROPN
aiua-13516	268	5	md	md	PROPN
aiua-13516	268	6	,	,	PUNCT
aiua-13516	268	7	rosenberg	rosenberg	PROPN
aiua-13516	268	8	je	je	PROPN
aiua-13516	268	9	,	,	PUNCT
aiua-13516	268	10	et	et	PROPN
aiua-13516	268	11	al	al	PROPN
aiua-13516	268	12	.	.	PROPN
aiua-13516	268	13	atezolizumab	atezolizumab	PROPN
aiua-13516	268	14	as	as	ADP
aiua-13516	268	15	firstline	firstline	ADJ
aiua-13516	268	16	treatment	treatment	NOUN
aiua-13516	268	17	in	in	ADP
aiua-13516	268	18	cisplatin	cisplatin	NOUN
aiua-13516	268	19	-	-	PUNCT
aiua-13516	268	20	ineligible	ineligible	ADJ
aiua-13516	268	21	patients	patient	NOUN
aiua-13516	268	22	with	with	ADP
aiua-13516	268	23	locally	locally	ADV
aiua-13516	268	24	advanced	advanced	ADJ
aiua-13516	268	25	and	and	CCONJ
aiua-13516	268	26	metastatic	metastatic	ADJ
aiua-13516	268	27	urothelial	urothelial	ADJ
aiua-13516	268	28	carcinoma	carcinoma	NOUN
aiua-13516	268	29	:	:	PUNCT
aiua-13516	268	30	a	a	DET
aiua-13516	268	31	single	single	ADJ
aiua-13516	268	32	-	-	PUNCT
aiua-13516	268	33	arm	arm	NOUN
aiua-13516	268	34	,	,	PUNCT
aiua-13516	268	35	multicentre	multicentre	NOUN
aiua-13516	268	36	,	,	PUNCT
aiua-13516	268	37	phase	phase	NOUN
aiua-13516	268	38	2	2	NUM
aiua-13516	268	39	trial	trial	NOUN
aiua-13516	268	40	.	.	PUNCT
aiua-13516	269	1	lancet	lancet	NOUN
aiua-13516	269	2	.	.	PUNCT
aiua-13516	270	1	2017	2017	NUM
aiua-13516	270	2	;	;	PUNCT
aiua-13516	271	1	389:67	389:67	NUM
aiua-13516	271	2	-	-	SYM
aiua-13516	271	3	76	76	NUM
aiua-13516	271	4	.	.	PUNCT
aiua-13516	272	1	21	21	NUM
aiua-13516	272	2	.	.	PUNCT
aiua-13516	272	3	motzer	motzer	PROPN
aiua-13516	272	4	rj	rj	PROPN
aiua-13516	272	5	,	,	PUNCT
aiua-13516	272	6	robbins	robbin	VERB
aiua-13516	272	7	pb	pb	ADP
aiua-13516	272	8	,	,	PUNCT
aiua-13516	272	9	powles	powle	VERB
aiua-13516	272	10	t	t	PROPN
aiua-13516	272	11	,	,	PUNCT
aiua-13516	272	12	et	et	PROPN
aiua-13516	272	13	al	al	PROPN
aiua-13516	272	14	.	.	PROPN
aiua-13516	272	15	avelumab	avelumab	PROPN
aiua-13516	272	16	plus	plus	CCONJ
aiua-13516	272	17	axitinib	axitinib	NOUN
aiua-13516	272	18	versus	versus	ADP
aiua-13516	272	19	sunitinib	sunitinib	NOUN
aiua-13516	272	20	in	in	ADP
aiua-13516	272	21	advanced	advanced	ADJ
aiua-13516	272	22	renal	renal	ADJ
aiua-13516	272	23	cell	cell	NOUN
aiua-13516	272	24	carcinoma	carcinoma	NOUN
aiua-13516	272	25	:	:	PUNCT
aiua-13516	272	26	biomarker	biomarker	VERB
aiua-13516	272	27	analysis	analysis	NOUN
aiua-13516	272	28	of	of	ADP
aiua-13516	272	29	the	the	DET
aiua-13516	272	30	phase	phase	NOUN
aiua-13516	272	31	3	3	NUM
aiua-13516	272	32	javelin	javelin	NOUN
aiua-13516	272	33	renal	renal	NOUN
aiua-13516	272	34	101	101	NUM
aiua-13516	272	35	trial	trial	NOUN
aiua-13516	272	36	.	.	PUNCT
aiua-13516	273	1	nat	nat	PROPN
aiua-13516	273	2	med	med	PROPN
aiua-13516	273	3	.	.	PUNCT
aiua-13516	273	4	2020	2020	NUM
aiua-13516	273	5	;	;	PUNCT
aiua-13516	273	6	26:1733	26:1733	X
aiua-13516	273	7	-	-	SYM
aiua-13516	273	8	41	41	NUM
aiua-13516	273	9	.	.	PUNCT
aiua-13516	274	1	22	22	NUM
aiua-13516	274	2	.	.	PUNCT
aiua-13516	275	1	sgarra	sgarra	PROPN
aiua-13516	275	2	r	r	PROPN
aiua-13516	275	3	,	,	PUNCT
aiua-13516	275	4	battista	battista	PROPN
aiua-13516	275	5	s	s	PROPN
aiua-13516	275	6	,	,	PUNCT
aiua-13516	275	7	cerchia	cerchia	PROPN
aiua-13516	275	8	l	l	NOUN
aiua-13516	275	9	,	,	PUNCT
aiua-13516	275	10	et	et	PROPN
aiua-13516	275	11	al	al	PROPN
aiua-13516	275	12	.	.	PUNCT
aiua-13516	275	13	mechanism	mechanism	NOUN
aiua-13516	275	14	of	of	ADP
aiua-13516	275	15	action	action	NOUN
aiua-13516	275	16	of	of	ADP
aiua-13516	275	17	lactic	lactic	ADJ
aiua-13516	275	18	acid	acid	NOUN
aiua-13516	275	19	on	on	ADP
aiua-13516	275	20	histones	histone	NOUN
aiua-13516	275	21	in	in	ADP
aiua-13516	275	22	cancer	cancer	NOUN
aiua-13516	275	23	.	.	PUNCT
aiua-13516	276	1	antioxid	antioxid	VERB
aiua-13516	276	2	redox	redox	NOUN
aiua-13516	276	3	signal	signal	NOUN
aiua-13516	276	4	.	.	PUNCT
aiua-13516	277	1	2023	2023	NUM
aiua-13516	277	2	;	;	PUNCT
aiua-13516	277	3	40:236	40:236	NUM
aiua-13516	277	4	-	-	SYM
aiua-13516	277	5	49	49	NUM
aiua-13516	277	6	.	.	PUNCT
aiua-13516	278	1	23	23	NUM
aiua-13516	278	2	.	.	PUNCT
aiua-13516	279	1	xu	xu	PROPN
aiua-13516	280	1	y	y	PROPN
aiua-13516	280	2	,	,	PUNCT
aiua-13516	280	3	hao	hao	PROPN
aiua-13516	280	4	x	x	PROPN
aiua-13516	280	5	,	,	PUNCT
aiua-13516	280	6	ren	ren	PROPN
aiua-13516	280	7	y	y	PROPN
aiua-13516	280	8	,	,	PUNCT
aiua-13516	280	9	et	et	PROPN
aiua-13516	280	10	al	al	PROPN
aiua-13516	280	11	.	.	PUNCT
aiua-13516	280	12	research	research	NOUN
aiua-13516	280	13	progress	progress	NOUN
aiua-13516	280	14	of	of	ADP
aiua-13516	280	15	abnormal	abnormal	ADJ
aiua-13516	280	16	lactate	lactate	NOUN
aiua-13516	280	17	metabolism	metabolism	NOUN
aiua-13516	280	18	and	and	CCONJ
aiua-13516	280	19	lactate	lactate	NOUN
aiua-13516	280	20	modification	modification	NOUN
aiua-13516	280	21	in	in	ADP
aiua-13516	280	22	immunotherapy	immunotherapy	NOUN
aiua-13516	280	23	of	of	ADP
aiua-13516	280	24	hepatocellular	hepatocellular	ADJ
aiua-13516	280	25	carcinoma	carcinoma	NOUN
aiua-13516	280	26	.	.	PUNCT
aiua-13516	281	1	front	front	ADJ
aiua-13516	281	2	oncol	oncol	ADJ
aiua-13516	281	3	.	.	PUNCT
aiua-13516	282	1	2022	2022	NUM
aiua-13516	282	2	;	;	PUNCT
aiua-13516	283	1	12:1063423	12:1063423	X
aiua-13516	283	2	.	.	NOUN
aiua-13516	283	3	24	24	NUM
aiua-13516	283	4	.	.	PUNCT
aiua-13516	284	1	zhang	zhang	PROPN
aiua-13516	284	2	q	q	X
aiua-13516	284	3	,	,	PUNCT
aiua-13516	284	4	liu	liu	PROPN
aiua-13516	284	5	s	s	PROPN
aiua-13516	284	6	,	,	PUNCT
aiua-13516	284	7	wang	wang	PROPN
aiua-13516	284	8	h	h	PROPN
aiua-13516	284	9	,	,	PUNCT
aiua-13516	284	10	et	et	PROPN
aiua-13516	284	11	al	al	PROPN
aiua-13516	284	12	.	.	PUNCT
aiua-13516	285	1	etv4	etv4	PROPN
aiua-13516	285	2	mediated	mediate	VERB
aiua-13516	285	3	tumorassociated	tumorassociate	VERB
aiua-13516	285	4	neutrophil	neutrophil	ADJ
aiua-13516	285	5	infiltration	infiltration	NOUN
aiua-13516	285	6	facilitates	facilitate	VERB
aiua-13516	285	7	lymphangiogenesis	lymphangiogenesis	NOUN
aiua-13516	285	8	and	and	CCONJ
aiua-13516	285	9	lymphatic	lymphatic	ADJ
aiua-13516	285	10	metastasis	metastasis	NOUN
aiua-13516	285	11	of	of	ADP
aiua-13516	285	12	bladder	bladder	NOUN
aiua-13516	285	13	cancer	cancer	NOUN
aiua-13516	285	14	.	.	PUNCT
aiua-13516	286	1	adv	adv	PROPN
aiua-13516	286	2	sci	sci	PROPN
aiua-13516	286	3	(	(	PUNCT
aiua-13516	286	4	weinh	weinh	PROPN
aiua-13516	286	5	)	)	PUNCT
aiua-13516	286	6	.	.	PUNCT
aiua-13516	287	1	2023	2023	NUM
aiua-13516	287	2	;	;	PUNCT
aiua-13516	287	3	10	10	NUM
aiua-13516	287	4	:	:	PUNCT
aiua-13516	287	5	e2205613	e2205613	ADJ
aiua-13516	287	6	.	.	PUNCT
aiua-13516	288	1	25	25	NUM
aiua-13516	288	2	.	.	PUNCT
aiua-13516	289	1	wang	wang	PROPN
aiua-13516	289	2	l	l	PROPN
aiua-13516	289	3	,	,	PUNCT
aiua-13516	289	4	li	li	PROPN
aiua-13516	289	5	s	s	PROPN
aiua-13516	289	6	,	,	PUNCT
aiua-13516	289	7	luo	luo	PROPN
aiua-13516	289	8	h	h	PROPN
aiua-13516	289	9	,	,	PUNCT
aiua-13516	289	10	et	et	PROPN
aiua-13516	289	11	al	al	PROPN
aiua-13516	289	12	.	.	PUNCT
aiua-13516	290	1	pcsk9	pcsk9	PROPN
aiua-13516	290	2	promotes	promote	VERB
aiua-13516	290	3	the	the	DET
aiua-13516	290	4	progression	progression	NOUN
aiua-13516	290	5	and	and	CCONJ
aiua-13516	290	6	metastasis	metastasis	NOUN
aiua-13516	290	7	of	of	ADP
aiua-13516	290	8	colon	colon	NOUN
aiua-13516	290	9	cancer	cancer	NOUN
aiua-13516	290	10	cells	cell	NOUN
aiua-13516	290	11	through	through	ADP
aiua-13516	290	12	regulation	regulation	NOUN
aiua-13516	290	13	of	of	ADP
aiua-13516	290	14	emt	emt	NOUN
aiua-13516	290	15	and	and	CCONJ
aiua-13516	290	16	pi3k	pi3k	PROPN
aiua-13516	290	17	/	/	SYM
aiua-13516	290	18	akt	akt	PROPN
aiua-13516	290	19	signaling	signal	VERB
aiua-13516	290	20	in	in	ADP
aiua-13516	290	21	tumor	tumor	NOUN
aiua-13516	290	22	cells	cell	NOUN
aiua-13516	290	23	and	and	CCONJ
aiua-13516	290	24	phenotypic	phenotypic	ADJ
aiua-13516	290	25	polarization	polarization	NOUN
aiua-13516	290	26	of	of	ADP
aiua-13516	290	27	macrophages	macrophage	NOUN
aiua-13516	290	28	.	.	PUNCT
aiua-13516	291	1	j	j	PROPN
aiua-13516	291	2	exp	exp	PROPN
aiua-13516	291	3	clin	clin	PROPN
aiua-13516	291	4	cancer	cancer	NOUN
aiua-13516	291	5	res	re	NOUN
aiua-13516	291	6	.	.	PUNCT
aiua-13516	291	7	2022	2022	NUM
aiua-13516	291	8	;	;	PUNCT
aiua-13516	291	9	41:303	41:303	X
aiua-13516	291	10	.	.	PUNCT
aiua-13516	292	1	26	26	NUM
aiua-13516	292	2	.	.	PUNCT
aiua-13516	293	1	wang	wang	PROPN
aiua-13516	293	2	x	x	PROPN
aiua-13516	293	3	,	,	PUNCT
aiua-13516	293	4	ying	ying	PROPN
aiua-13516	293	5	t	t	PROPN
aiua-13516	293	6	,	,	PUNCT
aiua-13516	293	7	yuan	yuan	PROPN
aiua-13516	293	8	j	j	PROPN
aiua-13516	293	9	,	,	PUNCT
aiua-13516	293	10	et	et	PROPN
aiua-13516	293	11	al	al	PROPN
aiua-13516	293	12	.	.	PROPN
aiua-13516	293	13	brafv600e	brafv600e	VERB
aiua-13516	293	14	restructures	restructure	VERB
aiua-13516	293	15	cellular	cellular	ADJ
aiua-13516	293	16	lactylation	lactylation	NOUN
aiua-13516	293	17	to	to	PART
aiua-13516	293	18	promote	promote	VERB
aiua-13516	293	19	anaplastic	anaplastic	ADJ
aiua-13516	293	20	thyroid	thyroid	NOUN
aiua-13516	293	21	cancer	cancer	NOUN
aiua-13516	293	22	proliferation	proliferation	NOUN
aiua-13516	293	23	.	.	PUNCT
aiua-13516	294	1	endocr	endocr	PROPN
aiua-13516	294	2	relat	relat	PROPN
aiua-13516	294	3	cancer	cancer	NOUN
aiua-13516	294	4	.	.	PUNCT
aiua-13516	295	1	2023	2023	NUM
aiua-13516	295	2	;	;	PUNCT
aiua-13516	295	3	30	30	NUM
aiua-13516	295	4	:	:	PUNCT
aiua-13516	295	5	e220344	e220344	PROPN
aiua-13516	295	6	.	.	PUNCT
aiua-13516	296	1	27	27	NUM
aiua-13516	296	2	.	.	PUNCT
aiua-13516	297	1	wu	wu	PROPN
aiua-13516	297	2	x.	x.	PROPN
aiua-13516	297	3	in	in	ADP
aiua-13516	297	4	-	-	PUNCT
aiua-13516	297	5	depth	depth	NOUN
aiua-13516	297	6	discovery	discovery	NOUN
aiua-13516	297	7	of	of	ADP
aiua-13516	297	8	protein	protein	NOUN
aiua-13516	297	9	lactylation	lactylation	NOUN
aiua-13516	297	10	in	in	ADP
aiua-13516	297	11	hepatocellular	hepatocellular	ADJ
aiua-13516	297	12	carcinoma	carcinoma	NOUN
aiua-13516	297	13	.	.	PUNCT
aiua-13516	298	1	proteomics	proteomic	NOUN
aiua-13516	298	2	.	.	PUNCT
aiua-13516	298	3	2023	2023	NUM
aiua-13516	298	4	;	;	PUNCT
aiua-13516	298	5	23	23	NUM
aiua-13516	298	6	:	:	PUNCT
aiua-13516	298	7	e2300003	e2300003	NUM
aiua-13516	298	8	.	.	NOUN
aiua-13516	298	9	28	28	NUM
aiua-13516	298	10	.	.	PUNCT
aiua-13516	299	1	li	li	PROPN
aiua-13516	299	2	f	f	PROPN
aiua-13516	299	3	,	,	PUNCT
aiua-13516	299	4	zhang	zhang	PROPN
aiua-13516	299	5	h	h	PROPN
aiua-13516	299	6	,	,	PUNCT
aiua-13516	299	7	huang	huang	PROPN
aiua-13516	299	8	y	y	PROPN
aiua-13516	299	9	,	,	PUNCT
aiua-13516	299	10	et	et	PROPN
aiua-13516	299	11	al	al	PROPN
aiua-13516	299	12	.	.	PUNCT
aiua-13516	300	1	single	single	ADJ
aiua-13516	300	2	-	-	PUNCT
aiua-13516	300	3	cell	cell	NOUN
aiua-13516	300	4	transcriptome	transcriptome	ADJ
aiua-13516	300	5	analysis	analysis	NOUN
aiua-13516	300	6	reveals	reveal	VERB
aiua-13516	300	7	the	the	DET
aiua-13516	300	8	association	association	NOUN
aiua-13516	300	9	between	between	ADP
aiua-13516	300	10	histone	histone	PROPN
aiua-13516	300	11	lactylation	lactylation	NOUN
aiua-13516	300	12	and	and	CCONJ
aiua-13516	300	13	cisplatin	cisplatin	NOUN
aiua-13516	300	14	resistance	resistance	NOUN
aiua-13516	300	15	in	in	ADP
aiua-13516	300	16	bladder	bladder	NOUN
aiua-13516	300	17	cancer	cancer	NOUN
aiua-13516	300	18	.	.	PUNCT
aiua-13516	301	1	drug	drug	NOUN
aiua-13516	301	2	resist	resist	VERB
aiua-13516	301	3	updat	updat	PROPN
aiua-13516	301	4	.	.	PROPN
aiua-13516	302	1	2024	2024	NUM
aiua-13516	302	2	;	;	PUNCT
aiua-13516	302	3	73:101059	73:101059	X
aiua-13516	302	4	.	.	X
aiua-13516	303	1	29	29	NUM
aiua-13516	303	2	.	.	PUNCT
aiua-13516	304	1	yang	yang	PROPN
aiua-13516	304	2	yh	yh	PROPN
aiua-13516	304	3	,	,	PUNCT
aiua-13516	304	4	wang	wang	PROPN
aiua-13516	304	5	qc	qc	PROPN
aiua-13516	304	6	,	,	PUNCT
aiua-13516	304	7	kong	kong	PROPN
aiua-13516	304	8	j	j	PROPN
aiua-13516	304	9	,	,	PUNCT
aiua-13516	304	10	et	et	PROPN
aiua-13516	304	11	al	al	PROPN
aiua-13516	304	12	.	.	PUNCT
aiua-13516	305	1	global	global	ADJ
aiua-13516	305	2	profiling	profiling	NOUN
aiua-13516	305	3	of	of	ADP
aiua-13516	305	4	lysine	lysine	NOUN
aiua-13516	305	5	lactylation	lactylation	NOUN
aiua-13516	305	6	in	in	ADP
aiua-13516	305	7	human	human	ADJ
aiua-13516	305	8	lungs	lung	NOUN
aiua-13516	305	9	.	.	PUNCT
aiua-13516	306	1	proteomics	proteomic	NOUN
aiua-13516	306	2	.	.	PUNCT
aiua-13516	306	3	2023	2023	NUM
aiua-13516	306	4	;	;	PUNCT
aiua-13516	306	5	23	23	NUM
aiua-13516	306	6	:	:	PUNCT
aiua-13516	306	7	e2200437	e2200437	NUM
aiua-13516	306	8	.	.	NOUN
aiua-13516	306	9	30	30	NUM
aiua-13516	306	10	.	.	PUNCT
aiua-13516	307	1	kotsiliti	kotsiliti	PROPN
aiua-13516	307	2	e.	e.	PROPN
aiua-13516	307	3	lactylation	lactylation	PROPN
aiua-13516	307	4	and	and	CCONJ
aiua-13516	307	5	hcc	hcc	PROPN
aiua-13516	307	6	progression	progression	NOUN
aiua-13516	307	7	.	.	PUNCT
aiua-13516	308	1	nat	nat	PROPN
aiua-13516	308	2	rev	rev	PROPN
aiua-13516	308	3	gastroenterol	gastroenterol	NOUN
aiua-13516	308	4	hepatol	hepatol	ADJ
aiua-13516	308	5	.	.	PUNCT
aiua-13516	309	1	2023	2023	NUM
aiua-13516	309	2	;	;	PUNCT
aiua-13516	309	3	20:131	20:131	NUM
aiua-13516	309	4	.	.	PUNCT
aiua-13516	310	1	31	31	NUM
aiua-13516	310	2	.	.	PUNCT
aiua-13516	311	1	yang	yang	PROPN
aiua-13516	311	2	h	h	PROPN
aiua-13516	311	3	,	,	PUNCT
aiua-13516	311	4	zou	zou	PROPN
aiua-13516	311	5	x	x	PROPN
aiua-13516	311	6	,	,	PUNCT
aiua-13516	311	7	yang	yang	PROPN
aiua-13516	311	8	s	s	PROPN
aiua-13516	311	9	,	,	PUNCT
aiua-13516	311	10	et	et	PROPN
aiua-13516	311	11	al	al	PROPN
aiua-13516	311	12	.	.	PUNCT
aiua-13516	311	13	identification	identification	NOUN
aiua-13516	311	14	of	of	ADP
aiua-13516	311	15	lactylation	lactylation	NOUN
aiua-13516	311	16	related	relate	VERB
aiua-13516	311	17	model	model	NOUN
aiua-13516	311	18	to	to	PART
aiua-13516	311	19	predict	predict	VERB
aiua-13516	311	20	prognostic	prognostic	PROPN
aiua-13516	311	21	,	,	PUNCT
aiua-13516	311	22	tumor	tumor	NOUN
aiua-13516	311	23	infiltrating	infiltrate	VERB
aiua-13516	311	24	immunocytes	immunocyte	NOUN
aiua-13516	311	25	and	and	CCONJ
aiua-13516	311	26	response	response	NOUN
aiua-13516	311	27	of	of	ADP
aiua-13516	311	28	immunotherapy	immunotherapy	NOUN
aiua-13516	311	29	in	in	ADP
aiua-13516	311	30	gastric	gastric	ADJ
aiua-13516	311	31	cancer	cancer	NOUN
aiua-13516	311	32	.	.	PUNCT
aiua-13516	312	1	front	front	ADJ
aiua-13516	312	2	immunol	immunol	NOUN
aiua-13516	312	3	.	.	PUNCT
aiua-13516	313	1	2023	2023	NUM
aiua-13516	313	2	;	;	PUNCT
aiua-13516	313	3	14:1149989	14:1149989	NUM
aiua-13516	313	4	.	.	PUNCT
aiua-13516	314	1	32	32	NUM
aiua-13516	314	2	.	.	PUNCT
aiua-13516	315	1	suh	suh	PROPN
aiua-13516	315	2	ks	ks	PROPN
aiua-13516	315	3	,	,	PUNCT
aiua-13516	315	4	yuspa	yuspa	PROPN
aiua-13516	315	5	sh	sh	PROPN
aiua-13516	315	6	.	.	PROPN
aiua-13516	315	7	intracellular	intracellular	ADJ
aiua-13516	315	8	chloride	chloride	NOUN
aiua-13516	315	9	channels	channel	NOUN
aiua-13516	315	10	:	:	PUNCT
aiua-13516	315	11	critical	critical	ADJ
aiua-13516	315	12	mediators	mediator	NOUN
aiua-13516	315	13	of	of	ADP
aiua-13516	315	14	cell	cell	NOUN
aiua-13516	315	15	viability	viability	NOUN
aiua-13516	315	16	and	and	CCONJ
aiua-13516	315	17	potential	potential	ADJ
aiua-13516	315	18	targets	target	NOUN
aiua-13516	315	19	for	for	ADP
aiua-13516	315	20	cancer	cancer	NOUN
aiua-13516	315	21	therapy	therapy	NOUN
aiua-13516	315	22	.	.	PUNCT
aiua-13516	316	1	curr	curr	PROPN
aiua-13516	316	2	pharm	pharm	PROPN
aiua-13516	316	3	des	des	PROPN
aiua-13516	316	4	.	.	PROPN
aiua-13516	316	5	2005	2005	NUM
aiua-13516	316	6	;	;	PUNCT
aiua-13516	316	7	11:2753	11:2753	NUM
aiua-13516	316	8	-	-	SYM
aiua-13516	316	9	64	64	NUM
aiua-13516	316	10	.	.	PUNCT
aiua-13516	317	1	33	33	NUM
aiua-13516	317	2	.	.	PUNCT
aiua-13516	318	1	flinck	flinck	PROPN
aiua-13516	318	2	m	m	PROPN
aiua-13516	318	3	,	,	PUNCT
aiua-13516	318	4	hagelund	hagelund	PROPN
aiua-13516	318	5	s	s	PART
aiua-13516	318	6	,	,	PUNCT
aiua-13516	318	7	gorbatenko	gorbatenko	VERB
aiua-13516	318	8	a	a	PRON
aiua-13516	318	9	,	,	PUNCT
aiua-13516	318	10	et	et	PROPN
aiua-13516	318	11	al	al	PROPN
aiua-13516	318	12	.	.	PUNCT
aiua-13516	319	1	the	the	DET
aiua-13516	319	2	vacuolar	vacuolar	ADJ
aiua-13516	319	3	h(+	h(+	NOUN
aiua-13516	319	4	)	)	PUNCT
aiua-13516	319	5	atpase	atpase	PROPN
aiua-13516	319	6	α3	α3	PROPN
aiua-13516	319	7	subunit	subunit	NOUN
aiua-13516	319	8	negatively	negatively	ADV
aiua-13516	319	9	regulates	regulate	VERB
aiua-13516	319	10	migration	migration	NOUN
aiua-13516	319	11	and	and	CCONJ
aiua-13516	319	12	invasion	invasion	NOUN
aiua-13516	319	13	of	of	ADP
aiua-13516	319	14	human	human	ADJ
aiua-13516	319	15	pancreatic	pancreatic	ADJ
aiua-13516	319	16	ductal	ductal	ADJ
aiua-13516	319	17	adenocarcinoma	adenocarcinoma	NOUN
aiua-13516	319	18	cells	cell	NOUN
aiua-13516	319	19	.	.	PUNCT
aiua-13516	320	1	cells	cell	NOUN
aiua-13516	320	2	.	.	PUNCT
aiua-13516	321	1	2020	2020	NUM
aiua-13516	321	2	;	;	PUNCT
aiua-13516	322	1	9:465	9:465	NUM
aiua-13516	322	2	.	.	PUNCT
aiua-13516	323	1	34	34	NUM
aiua-13516	323	2	.	.	PUNCT
aiua-13516	324	1	chen	chen	PROPN
aiua-13516	324	2	l	l	PROPN
aiua-13516	324	3	,	,	PUNCT
aiua-13516	324	4	huang	huang	PROPN
aiua-13516	324	5	l	l	PROPN
aiua-13516	324	6	,	,	PUNCT
aiua-13516	324	7	gu	gu	PROPN
aiua-13516	324	8	y	y	PROPN
aiua-13516	324	9	,	,	PUNCT
aiua-13516	324	10	et	et	PROPN
aiua-13516	324	11	al	al	PROPN
aiua-13516	324	12	.	.	PUNCT
aiua-13516	324	13	lactate	lactate	PROPN
aiua-13516	324	14	-	-	PUNCT
aiua-13516	324	15	lactylation	lactylation	NOUN
aiua-13516	324	16	hands	hand	NOUN
aiua-13516	324	17	between	between	ADP
aiua-13516	324	18	metabolic	metabolic	NOUN
aiua-13516	324	19	reprogramming	reprogramming	NOUN
aiua-13516	324	20	and	and	CCONJ
aiua-13516	324	21	immunosuppression	immunosuppression	NOUN
aiua-13516	324	22	.	.	PUNCT
aiua-13516	325	1	int	int	PROPN
aiua-13516	325	2	j	j	PROPN
aiua-13516	325	3	mol	mol	ADP
aiua-13516	325	4	sci	sci	PROPN
aiua-13516	325	5	.	.	PROPN
aiua-13516	325	6	2022	2022	NUM
aiua-13516	325	7	;	;	PUNCT
aiua-13516	325	8	23:11943	23:11943	NUM
aiua-13516	325	9	.	.	NOUN
aiua-13516	325	10	35	35	NUM
aiua-13516	325	11	.	.	PUNCT
aiua-13516	326	1	ji	ji	PROPN
aiua-13516	326	2	x	x	PROPN
aiua-13516	326	3	,	,	PUNCT
aiua-13516	326	4	nie	nie	PROPN
aiua-13516	326	5	c	c	PROPN
aiua-13516	326	6	,	,	PUNCT
aiua-13516	326	7	yao	yao	PROPN
aiua-13516	326	8	y	y	PROPN
aiua-13516	326	9	,	,	PUNCT
aiua-13516	326	10	et	et	PROPN
aiua-13516	326	11	al	al	PROPN
aiua-13516	326	12	.	.	PROPN
aiua-13516	326	13	s100a8/9	s100a8/9	PROPN
aiua-13516	326	14	modulates	modulate	NOUN
aiua-13516	326	15	perturbation	perturbation	NOUN
aiua-13516	326	16	and	and	CCONJ
aiua-13516	326	17	glycolysis	glycolysis	NOUN
aiua-13516	326	18	of	of	ADP
aiua-13516	326	19	macrophages	macrophage	NOUN
aiua-13516	326	20	in	in	ADP
aiua-13516	326	21	allergic	allergic	ADJ
aiua-13516	326	22	asthma	asthma	NOUN
aiua-13516	326	23	mice	mouse	NOUN
aiua-13516	326	24	.	.	PUNCT
aiua-13516	327	1	peerj	peerj	PROPN
aiua-13516	327	2	.	.	PUNCT
aiua-13516	328	1	2024	2024	NUM
aiua-13516	328	2	;	;	PUNCT
aiua-13516	328	3	12	12	NUM
aiua-13516	328	4	:	:	PUNCT
aiua-13516	328	5	e17106	e17106	PROPN
aiua-13516	328	6	.	.	PUNCT
aiua-13516	329	1	36	36	NUM
aiua-13516	329	2	.	.	PUNCT
aiua-13516	330	1	park	park	PROPN
aiua-13516	330	2	gb	gb	PROPN
aiua-13516	330	3	,	,	PUNCT
aiua-13516	330	4	kim	kim	PROPN
aiua-13516	330	5	d.	d.	PROPN
aiua-13516	330	6	tlr4	tlr4	PROPN
aiua-13516	330	7	-	-	PUNCT
aiua-13516	330	8	mediated	mediate	VERB
aiua-13516	330	9	galectin-1	galectin-1	PROPN
aiua-13516	330	10	production	production	NOUN
aiua-13516	330	11	triggers	trigger	VERB
aiua-13516	330	12	epithelial	epithelial	ADJ
aiua-13516	330	13	-	-	PUNCT
aiua-13516	330	14	mesenchymal	mesenchymal	ADJ
aiua-13516	330	15	transition	transition	NOUN
aiua-13516	330	16	in	in	ADP
aiua-13516	330	17	colon	colon	NOUN
aiua-13516	330	18	cancer	cancer	NOUN
aiua-13516	330	19	cells	cell	NOUN
aiua-13516	330	20	through	through	ADP
aiua-13516	330	21	adam10and	adam10and	NOUN
aiua-13516	330	22	adam17	adam17	NOUN
aiua-13516	330	23	-	-	PUNCT
aiua-13516	330	24	associated	associate	VERB
aiua-13516	330	25	lactate	lactate	NOUN
aiua-13516	330	26	production	production	NOUN
aiua-13516	330	27	.	.	PUNCT
aiua-13516	331	1	mol	mol	ADP
aiua-13516	331	2	cell	cell	NOUN
aiua-13516	331	3	biochem	biochem	PROPN
aiua-13516	331	4	.	.	PUNCT
aiua-13516	332	1	2017	2017	NUM
aiua-13516	332	2	;	;	PUNCT
aiua-13516	332	3	425:191	425:191	NOUN
aiua-13516	332	4	-	-	PROPN
aiua-13516	332	5	202	202	NUM
aiua-13516	332	6	.	.	PUNCT
aiua-13516	333	1	37	37	NUM
aiua-13516	333	2	.	.	PUNCT
aiua-13516	334	1	qin	qin	PROPN
aiua-13516	335	1	z	z	PROPN
aiua-13516	335	2	,	,	PUNCT
aiua-13516	335	3	tong	tong	PROPN
aiua-13516	335	4	h	h	PROPN
aiua-13516	335	5	,	,	PUNCT
aiua-13516	335	6	li	li	PROPN
aiua-13516	335	7	t	t	PROPN
aiua-13516	335	8	,	,	PUNCT
aiua-13516	335	9	et	et	PROPN
aiua-13516	335	10	al	al	PROPN
aiua-13516	335	11	.	.	PUNCT
aiua-13516	336	1	sphk1	sphk1	NOUN
aiua-13516	336	2	contributes	contribute	VERB
aiua-13516	336	3	to	to	ADP
aiua-13516	336	4	cisplatin	cisplatin	NOUN
aiua-13516	336	5	resistance	resistance	NOUN
aiua-13516	336	6	in	in	ADP
aiua-13516	336	7	bladder	bladder	NOUN
aiua-13516	336	8	cancer	cancer	NOUN
aiua-13516	336	9	cells	cell	NOUN
aiua-13516	336	10	via	via	ADP
aiua-13516	336	11	the	the	DET
aiua-13516	336	12	nono	nono	PROPN
aiua-13516	336	13	/	/	SYM
aiua-13516	336	14	stat3	stat3	NOUN
aiua-13516	336	15	axis	axis	NOUN
aiua-13516	336	16	.	.	PUNCT
aiua-13516	337	1	int	int	PROPN
aiua-13516	337	2	j	j	PROPN
aiua-13516	337	3	mol	mol	ADP
aiua-13516	337	4	med	med	PROPN
aiua-13516	337	5	.	.	PROPN
aiua-13516	337	6	2021	2021	NUM
aiua-13516	337	7	;	;	PUNCT
aiua-13516	337	8	48:204	48:204	NUM
aiua-13516	337	9	.	.	PUNCT
aiua-13516	338	1	38	38	NUM
aiua-13516	338	2	.	.	PUNCT
aiua-13516	338	3	gil	gil	PROPN
aiua-13516	338	4	da	da	PROPN
aiua-13516	338	5	costa	costa	PROPN
aiua-13516	338	6	rm	rm	PROPN
aiua-13516	338	7	,	,	PUNCT
aiua-13516	338	8	levesque	levesque	PROPN
aiua-13516	338	9	c	c	PROPN
aiua-13516	338	10	,	,	PUNCT
aiua-13516	338	11	bianchi	bianchi	NOUN
aiua-13516	338	12	-	-	PUNCT
aiua-13516	338	13	frias	frias	PROPN
aiua-13516	338	14	d	d	PROPN
aiua-13516	338	15	,	,	PUNCT
aiua-13516	338	16	et	et	PROPN
aiua-13516	338	17	al	al	PROPN
aiua-13516	338	18	.	.	PROPN
aiua-13516	338	19	pharmacological	pharmacological	ADJ
aiua-13516	338	20	nf	nf	PROPN
aiua-13516	338	21	-	-	PUNCT
aiua-13516	338	22	κb	κb	NOUN
aiua-13516	338	23	inhibition	inhibition	NOUN
aiua-13516	338	24	decreases	decrease	VERB
aiua-13516	338	25	cisplatin	cisplatin	NOUN
aiua-13516	338	26	chemoresistance	chemoresistance	NOUN
aiua-13516	338	27	in	in	ADP
aiua-13516	338	28	muscle	muscle	NOUN
aiua-13516	338	29	-	-	PUNCT
aiua-13516	338	30	invasive	invasive	ADJ
aiua-13516	338	31	bladder	bladder	NOUN
aiua-13516	338	32	cancer	cancer	NOUN
aiua-13516	338	33	and	and	CCONJ
aiua-13516	338	34	reduces	reduce	VERB
aiua-13516	338	35	cisplatininduced	cisplatininduced	ADJ
aiua-13516	338	36	toxicities	toxicity	NOUN
aiua-13516	338	37	.	.	PUNCT
aiua-13516	339	1	mol	mol	ADP
aiua-13516	339	2	oncol	oncol	ADJ
aiua-13516	339	3	.	.	PUNCT
aiua-13516	340	1	2023	2023	NUM
aiua-13516	340	2	;	;	PUNCT
aiua-13516	340	3	17:2709	17:2709	NUM
aiua-13516	340	4	-	-	SYM
aiua-13516	340	5	27	27	NUM
aiua-13516	340	6	.	.	NOUN
aiua-13516	340	7	39	39	NUM
aiua-13516	340	8	.	.	PUNCT
aiua-13516	341	1	ding	ding	PROPN
aiua-13516	341	2	j	j	PROPN
aiua-13516	341	3	,	,	PUNCT
aiua-13516	341	4	meng	meng	PROPN
aiua-13516	341	5	y	y	PROPN
aiua-13516	341	6	,	,	PUNCT
aiua-13516	341	7	han	han	PROPN
aiua-13516	341	8	z	z	PROPN
aiua-13516	341	9	,	,	PUNCT
aiua-13516	341	10	et	et	PROPN
aiua-13516	341	11	al	al	PROPN
aiua-13516	341	12	.	.	PROPN
aiua-13516	342	1	pan	pan	PROPN
aiua-13516	342	2	-	-	ADJ
aiua-13516	342	3	cancer	cancer	NOUN
aiua-13516	342	4	analysis	analysis	NOUN
aiua-13516	342	5	of	of	ADP
aiua-13516	342	6	the	the	DET
aiua-13516	342	7	oncogenic	oncogenic	ADJ
aiua-13516	342	8	and	and	CCONJ
aiua-13516	342	9	immunological	immunological	ADJ
aiua-13516	342	10	role	role	NOUN
aiua-13516	342	11	of	of	ADP
aiua-13516	342	12	rcn3	rcn3	NOUN
aiua-13516	342	13	:	:	PUNCT
aiua-13516	342	14	a	a	DET
aiua-13516	342	15	potential	potential	ADJ
aiua-13516	342	16	biomarker	biomarker	NOUN
aiua-13516	342	17	for	for	ADP
aiua-13516	342	18	prognosis	prognosis	NOUN
aiua-13516	342	19	and	and	CCONJ
aiua-13516	342	20	immunotherapy	immunotherapy	NOUN
aiua-13516	342	21	.	.	PUNCT
aiua-13516	343	1	front	front	ADJ
aiua-13516	343	2	oncol	oncol	ADJ
aiua-13516	343	3	.	.	PUNCT
aiua-13516	344	1	2022	2022	NUM
aiua-13516	344	2	;	;	PUNCT
aiua-13516	345	1	12:811567	12:811567	NUM
aiua-13516	345	2	.	.	NOUN
aiua-13516	345	3	40	40	NUM
aiua-13516	345	4	.	.	PUNCT
aiua-13516	346	1	liu	liu	PROPN
aiua-13516	346	2	w	w	PROPN
aiua-13516	346	3	,	,	PUNCT
aiua-13516	346	4	newhall	newhall	PROPN
aiua-13516	346	5	kp	kp	PROPN
aiua-13516	346	6	,	,	PUNCT
aiua-13516	346	7	khani	khani	PROPN
aiua-13516	346	8	f	f	PROPN
aiua-13516	346	9	,	,	PUNCT
aiua-13516	346	10	et	et	PROPN
aiua-13516	346	11	al	al	PROPN
aiua-13516	346	12	.	.	PUNCT
aiua-13516	347	1	the	the	DET
aiua-13516	347	2	cytidine	cytidine	NOUN
aiua-13516	347	3	deaminase	deaminase	NOUN
aiua-13516	347	4	apobec3	apobec3	PROPN
aiua-13516	347	5	g	g	PROPN
aiua-13516	347	6	contributes	contribute	VERB
aiua-13516	347	7	to	to	ADP
aiua-13516	347	8	cancer	cancer	NOUN
aiua-13516	347	9	mutagenesis	mutagenesis	NOUN
aiua-13516	347	10	and	and	CCONJ
aiua-13516	347	11	clonal	clonal	ADJ
aiua-13516	347	12	evolution	evolution	NOUN
aiua-13516	347	13	in	in	ADP
aiua-13516	347	14	bladder	bladder	NOUN
aiua-13516	347	15	cancer	cancer	NOUN
aiua-13516	347	16	.	.	PUNCT
aiua-13516	348	1	cancer	cancer	NOUN
aiua-13516	348	2	res	re	NOUN
aiua-13516	348	3	.	.	PUNCT
aiua-13516	349	1	2023	2023	NUM
aiua-13516	349	2	;	;	PUNCT
aiua-13516	349	3	83:506	83:506	NUM
aiua-13516	349	4	-	-	SYM
aiua-13516	349	5	20	20	NUM
aiua-13516	349	6	.	.	PUNCT
aiua-13516	350	1	41	41	NUM
aiua-13516	350	2	.	.	PUNCT
aiua-13516	351	1	huang	huang	PROPN
aiua-13516	351	2	l	l	PROPN
aiua-13516	351	3	,	,	PUNCT
aiua-13516	351	4	shao	shao	PROPN
aiua-13516	351	5	w	w	PROPN
aiua-13516	351	6	,	,	PUNCT
aiua-13516	351	7	wang	wang	PROPN
aiua-13516	351	8	x	x	PROPN
aiua-13516	351	9	,	,	PUNCT
aiua-13516	351	10	et	et	PROPN
aiua-13516	351	11	al	al	PROPN
aiua-13516	351	12	.	.	PUNCT
aiua-13516	352	1	tbx3	tbx3	PROPN
aiua-13516	352	2	stimulates	stimulate	VERB
aiua-13516	352	3	proliferation	proliferation	NOUN
aiua-13516	352	4	and	and	CCONJ
aiua-13516	352	5	stem	stem	NOUN
aiua-13516	352	6	cell	cell	NOUN
aiua-13516	352	7	self	self	NOUN
aiua-13516	352	8	-	-	PUNCT
aiua-13516	352	9	renewal	renewal	NOUN
aiua-13516	352	10	in	in	ADP
aiua-13516	352	11	bladder	bladder	NOUN
aiua-13516	352	12	carcinoma	carcinoma	NOUN
aiua-13516	352	13	.	.	PUNCT
aiua-13516	353	1	histol	histol	ADJ
aiua-13516	353	2	histopathol	histopathol	NOUN
aiua-13516	353	3	.	.	PUNCT
aiua-13516	354	1	2023	2023	NUM
aiua-13516	354	2	;	;	PUNCT
aiua-13516	354	3	38:65	38:65	NUM
aiua-13516	354	4	-	-	SYM
aiua-13516	354	5	72	72	NUM
aiua-13516	354	6	.	.	PUNCT
aiua-13516	355	1	42	42	NUM
aiua-13516	355	2	.	.	PUNCT
aiua-13516	356	1	majdalawieh	majdalawieh	PROPN
aiua-13516	356	2	af	af	PROPN
aiua-13516	356	3	,	,	PUNCT
aiua-13516	356	4	massri	massri	PROPN
aiua-13516	356	5	m	m	PROPN
aiua-13516	356	6	,	,	PUNCT
aiua-13516	356	7	ro	ro	PROPN
aiua-13516	356	8	hs	hs	PROPN
aiua-13516	356	9	.	.	PROPN
aiua-13516	356	10	aebp1	aebp1	PROPN
aiua-13516	356	11	is	be	AUX
aiua-13516	356	12	a	a	DET
aiua-13516	356	13	novel	novel	ADJ
aiua-13516	356	14	oncogene	oncogene	NOUN
aiua-13516	356	15	:	:	PUNCT
aiua-13516	356	16	mechanisms	mechanism	NOUN
aiua-13516	356	17	of	of	ADP
aiua-13516	356	18	action	action	NOUN
aiua-13516	356	19	and	and	CCONJ
aiua-13516	356	20	signaling	signal	VERB
aiua-13516	356	21	pathways	pathway	NOUN
aiua-13516	356	22	.	.	PUNCT
aiua-13516	357	1	j	j	PROPN
aiua-13516	357	2	oncol	oncol	ADJ
aiua-13516	357	3	.	.	PUNCT
aiua-13516	358	1	2020	2020	NUM
aiua-13516	358	2	;	;	PUNCT
aiua-13516	359	1	2020:8097872	2020:8097872	X
aiua-13516	359	2	.	.	PROPN
aiua-13516	360	1	43	43	NUM
aiua-13516	360	2	.	.	PUNCT
aiua-13516	361	1	somji	somji	NOUN
aiua-13516	361	2	s	s	PROPN
aiua-13516	361	3	,	,	PUNCT
aiua-13516	361	4	cao	cao	PROPN
aiua-13516	361	5	l	l	PROPN
aiua-13516	361	6	,	,	PUNCT
aiua-13516	361	7	mehus	mehus	PROPN
aiua-13516	361	8	a	a	PRON
aiua-13516	361	9	,	,	PUNCT
aiua-13516	361	10	et	et	PROPN
aiua-13516	361	11	al	al	PROPN
aiua-13516	361	12	.	.	PROPN
aiua-13516	361	13	comparison	comparison	NOUN
aiua-13516	361	14	of	of	ADP
aiua-13516	361	15	expression	expression	NOUN
aiua-13516	361	16	patterns	pattern	NOUN
aiua-13516	361	17	of	of	ADP
aiua-13516	361	18	keratin	keratin	NOUN
aiua-13516	361	19	6	6	NUM
aiua-13516	361	20	,	,	PUNCT
aiua-13516	361	21	7	7	NUM
aiua-13516	361	22	,	,	PUNCT
aiua-13516	361	23	16	16	NUM
aiua-13516	361	24	,	,	PUNCT
aiua-13516	361	25	17	17	NUM
aiua-13516	361	26	,	,	PUNCT
aiua-13516	361	27	and	and	CCONJ
aiua-13516	361	28	19	19	NUM
aiua-13516	361	29	within	within	ADP
aiua-13516	361	30	multiple	multiple	ADJ
aiua-13516	361	31	independent	independent	ADJ
aiua-13516	361	32	isolates	isolate	NOUN
aiua-13516	361	33	of	of	ADP
aiua-13516	361	34	as(+3)and	as(+3)and	PROPN
aiua-13516	361	35	cd	cd	PROPN
aiua-13516	361	36	(	(	PUNCT
aiua-13516	361	37	+2)-induced	+2)-induce	VERB
aiua-13516	361	38	bladder	bladder	NOUN
aiua-13516	361	39	cancer	cancer	NOUN
aiua-13516	361	40	:	:	PUNCT
aiua-13516	361	41	keratin	keratin	NOUN
aiua-13516	361	42	6	6	NUM
aiua-13516	361	43	,	,	PUNCT
aiua-13516	361	44	7	7	NUM
aiua-13516	361	45	,	,	PUNCT
aiua-13516	361	46	16	16	NUM
aiua-13516	361	47	,	,	PUNCT
aiua-13516	361	48	17	17	NUM
aiua-13516	361	49	,	,	PUNCT
aiua-13516	361	50	and	and	CCONJ
aiua-13516	361	51	19	19	NUM
aiua-13516	361	52	in	in	ADP
aiua-13516	361	53	bladder	bladder	NOUN
aiua-13516	361	54	cancer	cancer	NOUN
aiua-13516	361	55	.	.	PUNCT
aiua-13516	362	1	cell	cell	NOUN
aiua-13516	362	2	biol	biol	PROPN
aiua-13516	362	3	toxicol	toxicol	PROPN
aiua-13516	362	4	.	.	PUNCT
aiua-13516	363	1	2011	2011	NUM
aiua-13516	363	2	;	;	PUNCT
aiua-13516	363	3	27:38196	27:38196	NUM
aiua-13516	363	4	.	.	X
aiua-13516	364	1	44	44	NUM
aiua-13516	364	2	.	.	PUNCT
aiua-13516	365	1	liu	liu	PROPN
aiua-13516	365	2	x	x	PROPN
aiua-13516	365	3	,	,	PUNCT
aiua-13516	365	4	zhou	zhou	PROPN
aiua-13516	365	5	z	z	PROPN
aiua-13516	365	6	,	,	PUNCT
aiua-13516	365	7	wang	wang	PROPN
aiua-13516	365	8	y	y	PROPN
aiua-13516	365	9	,	,	PUNCT
aiua-13516	365	10	et	et	PROPN
aiua-13516	365	11	al	al	PROPN
aiua-13516	365	12	.	.	PUNCT
aiua-13516	366	1	downregulation	downregulation	NOUN
aiua-13516	366	2	of	of	ADP
aiua-13516	366	3	hmga1	hmga1	NOUN
aiua-13516	366	4	mediates	mediate	NOUN
aiua-13516	366	5	autophagy	autophagy	VERB
aiua-13516	366	6	and	and	CCONJ
aiua-13516	366	7	inhibits	inhibit	VERB
aiua-13516	366	8	migration	migration	NOUN
aiua-13516	366	9	and	and	CCONJ
aiua-13516	366	10	invasion	invasion	NOUN
aiua-13516	366	11	in	in	ADP
aiua-13516	366	12	bladder	bladder	NOUN
aiua-13516	366	13	cancer	cancer	NOUN
aiua-13516	366	14	via	via	ADP
aiua-13516	366	15	mirna-221	mirna-221	NOUN
aiua-13516	366	16	/	/	SYM
aiua-13516	366	17	tp53inp1	tp53inp1	PROPN
aiua-13516	366	18	/	/	SYM
aiua-13516	366	19	p	p	PROPN
aiua-13516	366	20	-	-	PUNCT
aiua-13516	366	21	erk	erk	NOUN
aiua-13516	366	22	axis	axis	NOUN
aiua-13516	366	23	.	.	PUNCT
aiua-13516	367	1	front	front	ADJ
aiua-13516	367	2	oncol	oncol	ADJ
aiua-13516	367	3	.	.	PUNCT
aiua-13516	368	1	2020	2020	NUM
aiua-13516	368	2	;	;	PUNCT
aiua-13516	369	1	10:589	10:589	NUM
aiua-13516	369	2	.	.	PUNCT
aiua-13516	370	1	45	45	NUM
aiua-13516	370	2	.	.	X
aiua-13516	370	3	pinato	pinato	PROPN
aiua-13516	370	4	dj	dj	PROPN
aiua-13516	370	5	,	,	PUNCT
aiua-13516	370	6	howlett	howlett	PROPN
aiua-13516	370	7	s	s	PROPN
aiua-13516	370	8	,	,	PUNCT
aiua-13516	370	9	ottaviani	ottaviani	PROPN
aiua-13516	370	10	d	d	NOUN
aiua-13516	370	11	,	,	PUNCT
aiua-13516	370	12	et	et	PROPN
aiua-13516	370	13	al	al	PROPN
aiua-13516	370	14	.	.	PROPN
aiua-13516	370	15	association	association	PROPN
aiua-13516	370	16	of	of	ADP
aiua-13516	370	17	prior	prior	ADJ
aiua-13516	370	18	declarations	declaration	NOUN
aiua-13516	370	19	ethical	ethical	ADJ
aiua-13516	370	20	approval	approval	NOUN
aiua-13516	370	21	:	:	PUNCT
aiua-13516	370	22	the	the	DET
aiua-13516	370	23	study	study	NOUN
aiua-13516	370	24	was	be	AUX
aiua-13516	370	25	approved	approve	VERB
aiua-13516	370	26	by	by	ADP
aiua-13516	370	27	the	the	DET
aiua-13516	370	28	institutional	institutional	PROPN
aiua-13516	370	29	review	review	PROPN
aiua-13516	370	30	board	board	NOUN
aiua-13516	370	31	of	of	ADP
aiua-13516	370	32	shantou	shantou	PROPN
aiua-13516	370	33	central	central	PROPN
aiua-13516	370	34	hospital	hospital	NOUN
aiua-13516	370	35	and	and	CCONJ
aiua-13516	370	36	carried	carry	VERB
aiua-13516	370	37	out	out	ADP
aiua-13516	370	38	following	follow	VERB
aiua-13516	370	39	the	the	DET
aiua-13516	370	40	declaration	declaration	NOUN
aiua-13516	370	41	of	of	ADP
aiua-13516	370	42	helsinki	helsinki	PROPN
aiua-13516	370	43	.	.	PUNCT
aiua-13516	371	1	availability	availability	NOUN
aiua-13516	371	2	of	of	ADP
aiua-13516	371	3	data	datum	NOUN
aiua-13516	371	4	and	and	CCONJ
aiua-13516	371	5	material	material	NOUN
aiua-13516	371	6	:	:	PUNCT
aiua-13516	371	7	the	the	DET
aiua-13516	371	8	data	datum	NOUN
aiua-13516	371	9	that	that	PRON
aiua-13516	371	10	support	support	VERB
aiua-13516	371	11	the	the	DET
aiua-13516	371	12	findings	finding	NOUN
aiua-13516	371	13	of	of	ADP
aiua-13516	371	14	this	this	DET
aiua-13516	371	15	study	study	NOUN
aiua-13516	371	16	are	be	AUX
aiua-13516	371	17	available	available	ADJ
aiua-13516	371	18	with	with	ADP
aiua-13516	371	19	the	the	DET
aiua-13516	371	20	article	article	NOUN
aiua-13516	371	21	and	and	CCONJ
aiua-13516	371	22	its	its	PRON
aiua-13516	371	23	supplementary	supplementary	ADJ
aiua-13516	371	24	material	material	NOUN
aiua-13516	371	25	,	,	PUNCT
aiua-13516	371	26	or	or	CCONJ
aiua-13516	371	27	are	be	AUX
aiua-13516	371	28	available	available	ADJ
aiua-13516	371	29	from	from	ADP
aiua-13516	371	30	the	the	DET
aiua-13516	371	31	corresponding	correspond	VERB
aiua-13516	371	32	authors	author	NOUN
aiua-13516	371	33	upon	upon	SCONJ
aiua-13516	371	34	reasonable	reasonable	ADJ
aiua-13516	371	35	request	request	NOUN
aiua-13516	371	36	.	.	PUNCT
aiua-13516	372	1	competing	compete	VERB
aiua-13516	372	2	interests	interest	NOUN
aiua-13516	372	3	:	:	PUNCT
aiua-13516	372	4	the	the	DET
aiua-13516	372	5	authors	author	NOUN
aiua-13516	372	6	declare	declare	VERB
aiua-13516	372	7	that	that	SCONJ
aiua-13516	372	8	there	there	PRON
aiua-13516	372	9	is	be	VERB
aiua-13516	372	10	no	no	DET
aiua-13516	372	11	conflict	conflict	NOUN
aiua-13516	372	12	of	of	ADP
aiua-13516	372	13	interest	interest	NOUN
aiua-13516	372	14	.	.	PUNCT
aiua-13516	373	1	funding	funding	NOUN
aiua-13516	373	2	:	:	PUNCT
aiua-13516	373	3	this	this	DET
aiua-13516	373	4	study	study	NOUN
aiua-13516	373	5	was	be	AUX
aiua-13516	373	6	supported	support	VERB
aiua-13516	373	7	by	by	ADP
aiua-13516	373	8	the	the	DET
aiua-13516	373	9	national	national	ADJ
aiua-13516	373	10	natural	natural	PROPN
aiua-13516	373	11	science	science	PROPN
aiua-13516	373	12	foundation	foundation	PROPN
aiua-13516	373	13	of	of	ADP
aiua-13516	373	14	china	china	PROPN
aiua-13516	373	15	(	(	PUNCT
aiua-13516	373	16	grant	grant	VERB
aiua-13516	373	17	no	no	INTJ
aiua-13516	373	18	.	.	NOUN
aiua-13516	373	19	82372685	82372685	NUM
aiua-13516	373	20	)	)	PUNCT
aiua-13516	373	21	,	,	PUNCT
aiua-13516	373	22	basic	basic	ADJ
aiua-13516	373	23	and	and	CCONJ
aiua-13516	373	24	applied	apply	VERB
aiua-13516	373	25	basic	basic	ADJ
aiua-13516	373	26	research	research	NOUN
aiua-13516	373	27	foundation	foundation	NOUN
aiua-13516	373	28	of	of	ADP
aiua-13516	373	29	guangdong	guangdong	PROPN
aiua-13516	373	30	province	province	PROPN
aiua-13516	373	31	(	(	PUNCT
aiua-13516	373	32	grant	grant	VERB
aiua-13516	373	33	no	no	NOUN
aiua-13516	373	34	.	.	PUNCT
aiua-13516	374	1	2023a1515220213	2023a1515220213	NUM
aiua-13516	374	2	)	)	PUNCT
aiua-13516	374	3	,	,	PUNCT
aiua-13516	374	4	science	science	NOUN
aiua-13516	374	5	and	and	CCONJ
aiua-13516	374	6	technology	technology	NOUN
aiua-13516	374	7	planning	planning	NOUN
aiua-13516	374	8	projects	project	NOUN
aiua-13516	374	9	of	of	ADP
aiua-13516	374	10	guangdong	guangdong	PROPN
aiua-13516	374	11	province	province	PROPN
aiua-13516	374	12	(	(	PUNCT
aiua-13516	374	13	grant	grant	VERB
aiua-13516	374	14	no	no	INTJ
aiua-13516	374	15	.	.	PUNCT
aiua-13516	375	1	stkj202209068	stkj202209068	PROPN
aiua-13516	375	2	)	)	PUNCT
aiua-13516	375	3	,	,	PUNCT
aiua-13516	375	4	science	science	NOUN
aiua-13516	375	5	and	and	CCONJ
aiua-13516	375	6	technology	technology	NOUN
aiua-13516	375	7	program	program	NOUN
aiua-13516	375	8	of	of	ADP
aiua-13516	375	9	shantou	shantou	PROPN
aiua-13516	375	10	city	city	PROPN
aiua-13516	375	11	(	(	PUNCT
aiua-13516	375	12	grant	grant	VERB
aiua-13516	375	13	no	no	NOUN
aiua-13516	375	14	.	.	PUNCT
aiua-13516	376	1	sfk[2023	sfk[2023	NUM
aiua-13516	376	2	]	]	X
aiua-13516	376	3	no.68	no.68	NOUN
aiua-13516	376	4	-	-	PUNCT
aiua-13516	376	5	1	1	NUM
aiua-13516	376	6	)	)	PUNCT
aiua-13516	376	7	.	.	PUNCT
aiua-13516	377	1	authors	author	NOUN
aiua-13516	377	2	'	'	PART
aiua-13516	377	3	contributions	contribution	NOUN
aiua-13516	377	4	:	:	PUNCT
aiua-13516	377	5	conceptualization	conceptualization	NOUN
aiua-13516	377	6	:	:	PUNCT
aiua-13516	377	7	x.h	x.h	PROPN
aiua-13516	377	8	and	and	CCONJ
aiua-13516	377	9	y.z	y.z	PROPN
aiua-13516	377	10	.	.	PROPN
aiua-13516	377	11	;	;	PUNCT
aiua-13516	377	12	investigation	investigation	NOUN
aiua-13516	377	13	:	:	PUNCT
aiua-13516	378	1	g.l	g.l	PROPN
aiua-13516	378	2	.	.	PROPN
aiua-13516	378	3	,	,	PUNCT
aiua-13516	378	4	t.h	t.h	PROPN
aiua-13516	378	5	.	.	PROPN
aiua-13516	378	6	;	;	PUNCT
aiua-13516	378	7	and	and	CCONJ
aiua-13516	378	8	x.l	x.l	PROPN
aiua-13516	378	9	.	.	PROPN
aiua-13516	378	10	data	datum	NOUN
aiua-13516	378	11	curation	curation	NOUN
aiua-13516	378	12	:	:	PUNCT
aiua-13516	378	13	t.h	t.h	PROPN
aiua-13516	378	14	.	.	PROPN
aiua-13516	378	15	and	and	CCONJ
aiua-13516	378	16	x.l	x.l	PROPN
aiua-13516	378	17	.	.	PUNCT
aiua-13516	378	18	;	;	PUNCT
aiua-13516	378	19	formal	formal	ADJ
aiua-13516	378	20	analysis	analysis	NOUN
aiua-13516	378	21	:	:	PUNCT
aiua-13516	378	22	g.l	g.l	PROPN
aiua-13516	378	23	.	.	PROPN
aiua-13516	378	24	;	;	PUNCT
aiua-13516	378	25	methodology	methodology	NOUN
aiua-13516	378	26	:	:	PUNCT
aiua-13516	378	27	x.l	x.l	PROPN
aiua-13516	378	28	.	.	PUNCT
aiua-13516	378	29	;	;	PUNCT
aiua-13516	378	30	resources	resource	NOUN
aiua-13516	378	31	:	:	PUNCT
aiua-13516	378	32	p.y	p.y	PROPN
aiua-13516	378	33	.	.	PROPN
aiua-13516	378	34	;	;	PUNCT
aiua-13516	378	35	software	software	NOUN
aiua-13516	378	36	:	:	PUNCT
aiua-13516	378	37	x.c	x.c	PROPN
aiua-13516	378	38	.	.	PROPN
aiua-13516	378	39	;	;	PUNCT
aiua-13516	378	40	writing	write	VERB
aiua-13516	378	41	original	original	ADJ
aiua-13516	378	42	draft	draft	NOUN
aiua-13516	378	43	:	:	PUNCT
aiua-13516	378	44	g.l	g.l	PROPN
aiua-13516	378	45	.	.	PROPN
aiua-13516	378	46	and	and	CCONJ
aiua-13516	378	47	t.h	t.h	PROPN
aiua-13516	378	48	.	.	PROPN
aiua-13516	378	49	;	;	PUNCT
aiua-13516	378	50	writing	write	VERB
aiua-13516	378	51	review	review	NOUN
aiua-13516	378	52	&	&	CCONJ
aiua-13516	378	53	editing	editing	PROPN
aiua-13516	378	54	:	:	PUNCT
aiua-13516	378	55	x.h	x.h	PROPN
aiua-13516	378	56	.	.	PROPN
aiua-13516	378	57	,	,	PUNCT
aiua-13516	378	58	k.s	k.s	PROPN
aiua-13516	378	59	.	.	PROPN
aiua-13516	378	60	and	and	CCONJ
aiua-13516	378	61	y.z	y.z	PROPN
aiua-13516	378	62	.	.	PROPN
aiua-13516	378	63	funding	funding	PROPN
aiua-13516	378	64	acquisition	acquisition	NOUN
aiua-13516	378	65	:	:	PUNCT
aiua-13516	378	66	x.h	x.h	PROPN
aiua-13516	378	67	.	.	PROPN
aiua-13516	378	68	and	and	CCONJ
aiua-13516	378	69	y.z	y.z	PROPN
aiua-13516	378	70	.	.	PROPN
aiua-13516	378	71	consent	consent	NOUN
aiua-13516	378	72	for	for	ADP
aiua-13516	378	73	publication	publication	NOUN
aiua-13516	378	74	:	:	PUNCT
aiua-13516	378	75	all	all	DET
aiua-13516	378	76	authors	author	NOUN
aiua-13516	378	77	have	have	AUX
aiua-13516	378	78	read	read	VERB
aiua-13516	378	79	and	and	CCONJ
aiua-13516	378	80	approved	approve	VERB
aiua-13516	378	81	the	the	DET
aiua-13516	378	82	content	content	NOUN
aiua-13516	378	83	and	and	CCONJ
aiua-13516	378	84	agree	agree	VERB
aiua-13516	378	85	to	to	PART
aiua-13516	378	86	submit	submit	VERB
aiua-13516	378	87	for	for	ADP
aiua-13516	378	88	consideration	consideration	NOUN
aiua-13516	378	89	for	for	ADP
aiua-13516	378	90	publication	publication	NOUN
aiua-13516	378	91	in	in	ADP
aiua-13516	378	92	the	the	DET
aiua-13516	378	93	journal	journal	NOUN
aiua-13516	378	94	.	.	PUNCT
aiua-13516	379	1	acknowledgments	acknowledgment	NOUN
aiua-13516	379	2	:	:	PUNCT
aiua-13516	379	3	none	none	NOUN
aiua-13516	379	4	.	.	PUNCT
aiua-13516	380	1	archivio	archivio	NOUN
aiua-13516	380	2	italiano	italiano	PROPN
aiua-13516	380	3	di	di	PROPN
aiua-13516	380	4	urologia	urologia	PROPN
aiua-13516	380	5	e	e	PROPN
aiua-13516	380	6	andrologia	andrologia	NOUN
aiua-13516	380	7	2025	2025	NUM
aiua-13516	380	8	;	;	PUNCT
aiua-13516	380	9	97(1):13516	97(1):13516	NUM
aiua-13516	380	10	13	13	NUM
aiua-13516	380	11	lactylation	lactylation	NOUN
aiua-13516	380	12	-	-	PUNCT
aiua-13516	380	13	related	relate	VERB
aiua-13516	380	14	gene	gene	NOUN
aiua-13516	380	15	signature	signature	NOUN
aiua-13516	380	16	in	in	ADP
aiua-13516	380	17	bladder	bladder	NOUN
aiua-13516	380	18	cancer	cancer	NOUN
aiua-13516	380	19	antibiotic	antibiotic	ADJ
aiua-13516	380	20	treatment	treatment	NOUN
aiua-13516	380	21	with	with	ADP
aiua-13516	380	22	survival	survival	NOUN
aiua-13516	380	23	and	and	CCONJ
aiua-13516	380	24	response	response	NOUN
aiua-13516	380	25	to	to	ADP
aiua-13516	380	26	immune	immune	ADJ
aiua-13516	380	27	checkpoint	checkpoint	NOUN
aiua-13516	380	28	inhibitor	inhibitor	NOUN
aiua-13516	380	29	therapy	therapy	NOUN
aiua-13516	380	30	in	in	ADP
aiua-13516	380	31	patients	patient	NOUN
aiua-13516	380	32	with	with	ADP
aiua-13516	380	33	cancer	cancer	NOUN
aiua-13516	380	34	.	.	PUNCT
aiua-13516	381	1	jama	jama	PROPN
aiua-13516	381	2	oncol	oncol	ADJ
aiua-13516	381	3	.	.	PUNCT
aiua-13516	381	4	2019	2019	NUM
aiua-13516	381	5	;	;	PUNCT
aiua-13516	381	6	5:1774	5:1774	NUM
aiua-13516	381	7	-	-	SYM
aiua-13516	381	8	8	8	NUM
aiua-13516	381	9	.	.	PUNCT
aiua-13516	381	10	46	46	NUM
aiua-13516	381	11	.	.	PUNCT
aiua-13516	382	1	liu	liu	PROPN
aiua-13516	382	2	l	l	PROPN
aiua-13516	382	3	,	,	PUNCT
aiua-13516	382	4	bai	bai	PROPN
aiua-13516	382	5	x	x	PROPN
aiua-13516	382	6	,	,	PUNCT
aiua-13516	382	7	wang	wang	PROPN
aiua-13516	382	8	j	j	PROPN
aiua-13516	382	9	,	,	PUNCT
aiua-13516	382	10	et	et	PROPN
aiua-13516	382	11	al	al	PROPN
aiua-13516	382	12	.	.	PROPN
aiua-13516	382	13	combination	combination	NOUN
aiua-13516	382	14	of	of	ADP
aiua-13516	382	15	tmb	tmb	PROPN
aiua-13516	382	16	and	and	CCONJ
aiua-13516	382	17	cna	cna	PROPN
aiua-13516	382	18	stratifies	stratify	VERB
aiua-13516	382	19	prognostic	prognostic	ADJ
aiua-13516	382	20	and	and	CCONJ
aiua-13516	382	21	predictive	predictive	ADJ
aiua-13516	382	22	responses	response	NOUN
aiua-13516	382	23	to	to	ADP
aiua-13516	382	24	immunotherapy	immunotherapy	NOUN
aiua-13516	382	25	across	across	ADP
aiua-13516	382	26	metastatic	metastatic	ADJ
aiua-13516	382	27	cancer	cancer	NOUN
aiua-13516	382	28	.	.	PUNCT
aiua-13516	383	1	clin	clin	PROPN
aiua-13516	383	2	cancer	cancer	NOUN
aiua-13516	383	3	res	re	NOUN
aiua-13516	383	4	.	.	PROPN
aiua-13516	383	5	2019	2019	NUM
aiua-13516	383	6	;	;	PUNCT
aiua-13516	383	7	25:7413	25:7413	NUM
aiua-13516	383	8	-	-	SYM
aiua-13516	383	9	23	23	NUM
aiua-13516	383	10	.	.	PUNCT
aiua-13516	384	1	47	47	NUM
aiua-13516	384	2	.	.	PUNCT
aiua-13516	385	1	bule	bule	PROPN
aiua-13516	385	2	p	p	PROPN
aiua-13516	385	3	,	,	PUNCT
aiua-13516	385	4	aguiar	aguiar	ADJ
aiua-13516	385	5	si	si	NOUN
aiua-13516	385	6	,	,	PUNCT
aiua-13516	385	7	aires	aires	PROPN
aiua-13516	385	8	-	-	PUNCT
aiua-13516	385	9	da	da	ADJ
aiua-13516	385	10	-	-	PUNCT
aiua-13516	385	11	silva	silva	NOUN
aiua-13516	385	12	f	f	PROPN
aiua-13516	385	13	,	,	PUNCT
aiua-13516	385	14	dias	dias	PROPN
aiua-13516	385	15	jnr	jnr	PROPN
aiua-13516	385	16	.	.	PROPN
aiua-13516	385	17	chemokinedirected	chemokinedirecte	VERB
aiua-13516	385	18	tumor	tumor	NOUN
aiua-13516	385	19	microenvironment	microenvironment	ADJ
aiua-13516	385	20	modulation	modulation	NOUN
aiua-13516	385	21	in	in	ADP
aiua-13516	385	22	cancer	cancer	NOUN
aiua-13516	385	23	immunotherapy	immunotherapy	NOUN
aiua-13516	385	24	.	.	PUNCT
aiua-13516	386	1	int	int	PROPN
aiua-13516	386	2	j	j	PROPN
aiua-13516	386	3	mol	mol	ADP
aiua-13516	386	4	sci	sci	PROPN
aiua-13516	386	5	.	.	PROPN
aiua-13516	386	6	2021	2021	NUM
aiua-13516	386	7	;	;	PUNCT
aiua-13516	386	8	22	22	NUM
aiua-13516	386	9	.	.	X
aiua-13516	386	10	48	48	NUM
aiua-13516	386	11	.	.	PUNCT
aiua-13516	387	1	peng	peng	PROPN
aiua-13516	387	2	q	q	PROPN
aiua-13516	387	3	,	,	PUNCT
aiua-13516	387	4	qiu	qiu	PROPN
aiua-13516	387	5	x	x	SYM
aiua-13516	387	6	,	,	PUNCT
aiua-13516	387	7	zhang	zhang	PROPN
aiua-13516	387	8	z	z	PROPN
aiua-13516	387	9	,	,	PUNCT
aiua-13516	387	10	et	et	PROPN
aiua-13516	387	11	al	al	PROPN
aiua-13516	387	12	.	.	PROPN
aiua-13516	387	13	pd	pd	PROPN
aiua-13516	387	14	-	-	PROPN
aiua-13516	387	15	l1	l1	PROPN
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aiua-13516	387	20	t	t	NOUN
aiua-13516	387	21	cell	cell	NOUN
aiua-13516	387	22	activation	activation	NOUN
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aiua-13516	387	24	regulates	regulate	VERB
aiua-13516	387	25	response	response	NOUN
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aiua-13516	390	23	liu	liu	PROPN
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aiua-13516	391	12	china	china	PROPN
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aiua-13516	391	14	lin	lin	PROPN
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aiua-13516	392	1	peixiu	peixiu	PROPN
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aiua-13516	392	10	,	,	PUNCT
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aiua-13516	392	12	central	central	PROPN
aiua-13516	392	13	hospital	hospital	PROPN
aiua-13516	392	14	,	,	PUNCT
aiua-13516	392	15	shantou	shantou	PROPN
aiua-13516	392	16	,	,	PUNCT
aiua-13516	392	17	china	china	PROPN
aiua-13516	392	18	kemal	kemal	PROPN
aiua-13516	392	19	sarica	sarica	PROPN
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aiua-13516	393	1	department	department	PROPN
aiua-13516	393	2	of	of	ADP
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aiua-13516	393	4	,	,	PUNCT
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aiua-13516	394	7	training	training	NOUN
aiua-13516	394	8	hospital	hospital	NOUN
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aiua-13516	394	28	shantou	shantou	PROPN
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aiua-13516	394	32	.	.	PROPN
aiua-13516	394	33	china	china	PROPN