id	sid	tid	token	lemma	pos
aiua-13762	1	1	stesura	stesura	PROPN
aiua-13762	1	2	seveso	seveso	PROPN
aiua-13762	1	3	archivio	archivio	PROPN
aiua-13762	1	4	italiano	italiano	X
aiua-13762	1	5	di	di	X
aiua-13762	1	6	urologia	urologia	PROPN
aiua-13762	1	7	e	e	PROPN
aiua-13762	1	8	andrologia	andrologia	NOUN
aiua-13762	1	9	2025	2025	NUM
aiua-13762	1	10	;	;	PUNCT
aiua-13762	1	11	97(2):13762	97(2):13762	NUM
aiua-13762	1	12	1	1	NUM
aiua-13762	1	13	review	review	NOUN
aiua-13762	1	14	introduction	introduction	NOUN
aiua-13762	1	15	prostate	prostate	NOUN
aiua-13762	1	16	cancer	cancer	NOUN
aiua-13762	1	17	(	(	PUNCT
aiua-13762	1	18	pca	pca	PROPN
aiua-13762	1	19	)	)	PUNCT
aiua-13762	1	20	is	be	AUX
aiua-13762	1	21	the	the	DET
aiua-13762	1	22	most	most	ADV
aiua-13762	1	23	prevalent	prevalent	ADJ
aiua-13762	1	24	form	form	NOUN
aiua-13762	1	25	of	of	ADP
aiua-13762	1	26	cancer	cancer	NOUN
aiua-13762	1	27	among	among	ADP
aiua-13762	1	28	men	man	NOUN
aiua-13762	1	29	in	in	ADP
aiua-13762	1	30	the	the	DET
aiua-13762	1	31	european	european	PROPN
aiua-13762	1	32	union	union	PROPN
aiua-13762	1	33	,	,	PUNCT
aiua-13762	1	34	the	the	DET
aiua-13762	1	35	usa	usa	PROPN
aiua-13762	1	36	and	and	CCONJ
aiua-13762	1	37	israel	israel	PROPN
aiua-13762	1	38	(	(	PUNCT
aiua-13762	1	39	1	1	NUM
aiua-13762	1	40	)	)	PUNCT
aiua-13762	1	41	.	.	PUNCT
aiua-13762	2	1	alongside	alongside	ADP
aiua-13762	2	2	factors	factor	NOUN
aiua-13762	2	3	such	such	ADJ
aiua-13762	2	4	as	as	ADP
aiua-13762	2	5	age	age	NOUN
aiua-13762	2	6	,	,	PUNCT
aiua-13762	2	7	diet	diet	NOUN
aiua-13762	2	8	and	and	CCONJ
aiua-13762	2	9	lifestyle	lifestyle	NOUN
aiua-13762	2	10	,	,	PUNCT
aiua-13762	2	11	heritability	heritability	NOUN
aiua-13762	2	12	has	have	AUX
aiua-13762	2	13	emerged	emerge	VERB
aiua-13762	2	14	as	as	ADP
aiua-13762	2	15	a	a	DET
aiua-13762	2	16	significant	significant	ADJ
aiua-13762	2	17	determinant	determinant	NOUN
aiua-13762	2	18	of	of	ADP
aiua-13762	2	19	pca	pca	NOUN
aiua-13762	2	20	risk	risk	NOUN
aiua-13762	2	21	(	(	PUNCT
aiua-13762	2	22	2	2	NUM
aiua-13762	2	23	)	)	PUNCT
aiua-13762	2	24	.	.	PUNCT
aiua-13762	3	1	epidemiological	epidemiological	ADJ
aiua-13762	3	2	and	and	CCONJ
aiua-13762	3	3	genetic	genetic	ADJ
aiua-13762	3	4	studies	study	NOUN
aiua-13762	3	5	indicate	indicate	VERB
aiua-13762	3	6	a	a	DET
aiua-13762	3	7	hereditary	hereditary	ADJ
aiua-13762	3	8	predisposition	predisposition	NOUN
aiua-13762	3	9	in	in	ADP
aiua-13762	3	10	approximately	approximately	ADV
aiua-13762	3	11	5	5	NUM
aiua-13762	3	12	-	-	SYM
aiua-13762	3	13	10	10	NUM
aiua-13762	3	14	%	%	NOUN
aiua-13762	3	15	of	of	ADP
aiua-13762	3	16	all	all	DET
aiua-13762	3	17	pca	pca	NOUN
aiua-13762	3	18	cases	case	NOUN
aiua-13762	3	19	(	(	PUNCT
aiua-13762	3	20	3	3	NUM
aiua-13762	3	21	)	)	PUNCT
aiua-13762	3	22	.	.	PUNCT
aiua-13762	4	1	first	first	ADJ
aiua-13762	4	2	-	-	PUNCT
aiua-13762	4	3	degree	degree	NOUN
aiua-13762	4	4	relatives	relative	NOUN
aiua-13762	4	5	of	of	ADP
aiua-13762	4	6	affected	affect	VERB
aiua-13762	4	7	individuals	individual	NOUN
aiua-13762	4	8	have	have	VERB
aiua-13762	4	9	a	a	DET
aiua-13762	4	10	relative	relative	ADJ
aiua-13762	4	11	risk	risk	NOUN
aiua-13762	4	12	of	of	ADP
aiua-13762	4	13	developing	develop	VERB
aiua-13762	4	14	pca	pca	NOUN
aiua-13762	4	15	ranging	range	VERB
aiua-13762	4	16	from	from	ADP
aiua-13762	4	17	1.65	1.65	NUM
aiua-13762	4	18	to	to	ADP
aiua-13762	4	19	3.3	3.3	NUM
aiua-13762	4	20	,	,	PUNCT
aiua-13762	4	21	the	the	DET
aiua-13762	4	22	risk	risk	NOUN
aiua-13762	4	23	increasing	increase	VERB
aiua-13762	4	24	for	for	ADP
aiua-13762	4	25	those	those	PRON
aiua-13762	4	26	with	with	ADP
aiua-13762	4	27	an	an	DET
aiua-13762	4	28	earlier	early	ADJ
aiua-13762	4	29	diagnosis	diagnosis	NOUN
aiua-13762	4	30	or	or	CCONJ
aiua-13762	4	31	multiple	multiple	ADJ
aiua-13762	4	32	affected	affected	ADJ
aiua-13762	4	33	family	family	NOUN
aiua-13762	4	34	members	member	NOUN
aiua-13762	4	35	.	.	PUNCT
aiua-13762	5	1	specifically	specifically	ADV
aiua-13762	5	2	,	,	PUNCT
aiua-13762	5	3	having	have	VERB
aiua-13762	5	4	one	one	NUM
aiua-13762	5	5	,	,	PUNCT
aiua-13762	5	6	two	two	NUM
aiua-13762	5	7	,	,	PUNCT
aiua-13762	5	8	or	or	CCONJ
aiua-13762	5	9	three	three	NUM
aiua-13762	5	10	affected	affected	ADJ
aiua-13762	5	11	first	first	ADJ
aiua-13762	5	12	-	-	PUNCT
aiua-13762	5	13	degree	degree	NOUN
aiua-13762	5	14	relatives	relative	NOUN
aiua-13762	5	15	progressively	progressively	ADV
aiua-13762	5	16	increases	increase	VERB
aiua-13762	5	17	the	the	DET
aiua-13762	5	18	risk	risk	NOUN
aiua-13762	5	19	ratio	ratio	NOUN
aiua-13762	5	20	for	for	ADP
aiua-13762	5	21	pca	pca	NOUN
aiua-13762	5	22	by	by	ADP
aiua-13762	5	23	2.2	2.2	NUM
aiua-13762	5	24	,	,	PUNCT
aiua-13762	5	25	4.9	4.9	NUM
aiua-13762	5	26	,	,	PUNCT
aiua-13762	5	27	and	and	CCONJ
aiua-13762	5	28	10.9	10.9	NUM
aiua-13762	5	29	times	time	NOUN
aiua-13762	5	30	,	,	PUNCT
aiua-13762	5	31	respectively	respectively	ADV
aiua-13762	5	32	(	(	PUNCT
aiua-13762	5	33	4	4	NUM
aiua-13762	5	34	)	)	PUNCT
aiua-13762	5	35	.	.	PUNCT
aiua-13762	6	1	twin	twin	PROPN
aiua-13762	6	2	studies	study	NOUN
aiua-13762	6	3	suggest	suggest	VERB
aiua-13762	6	4	that	that	SCONJ
aiua-13762	6	5	approximately	approximately	ADV
aiua-13762	6	6	40	40	NUM
aiua-13762	6	7	%	%	NOUN
aiua-13762	6	8	of	of	ADP
aiua-13762	6	9	pca	pca	NOUN
aiua-13762	6	10	cases	case	NOUN
aiua-13762	6	11	may	may	AUX
aiua-13762	6	12	have	have	VERB
aiua-13762	6	13	a	a	DET
aiua-13762	6	14	hereditary	hereditary	ADJ
aiua-13762	6	15	component	component	NOUN
aiua-13762	6	16	(	(	PUNCT
aiua-13762	6	17	5	5	NUM
aiua-13762	6	18	)	)	PUNCT
aiua-13762	6	19	,	,	PUNCT
aiua-13762	6	20	while	while	SCONJ
aiua-13762	6	21	meta	meta	ADJ
aiua-13762	6	22	-	-	PUNCT
aiua-13762	6	23	analyses	analysis	NOUN
aiua-13762	6	24	indicate	indicate	VERB
aiua-13762	6	25	that	that	SCONJ
aiua-13762	6	26	having	have	VERB
aiua-13762	6	27	an	an	DET
aiua-13762	6	28	affected	affected	ADJ
aiua-13762	6	29	brother	brother	NOUN
aiua-13762	6	30	or	or	CCONJ
aiua-13762	6	31	father	father	NOUN
aiua-13762	6	32	increases	increase	VERB
aiua-13762	6	33	the	the	DET
aiua-13762	6	34	risk	risk	NOUN
aiua-13762	6	35	of	of	ADP
aiua-13762	6	36	developing	develop	VERB
aiua-13762	6	37	the	the	DET
aiua-13762	6	38	disease	disease	NOUN
aiua-13762	6	39	by	by	ADP
aiua-13762	6	40	2.9	2.9	NUM
aiua-13762	6	41	-	-	NOUN
aiua-13762	6	42	fold	fold	ADJ
aiua-13762	6	43	or	or	CCONJ
aiua-13762	6	44	2.12	2.12	NUM
aiua-13762	6	45	-	-	ADJ
aiua-13762	6	46	fold	fold	ADJ
aiua-13762	6	47	,	,	PUNCT
aiua-13762	6	48	respectively	respectively	ADV
aiua-13762	6	49	.	.	PUNCT
aiua-13762	7	1	the	the	DET
aiua-13762	7	2	risk	risk	NOUN
aiua-13762	7	3	for	for	ADP
aiua-13762	7	4	firstand	firstand	NOUN
aiua-13762	7	5	second	second	ADJ
aiua-13762	7	6	-	-	PUNCT
aiua-13762	7	7	degree	degree	NOUN
aiua-13762	7	8	relatives	relative	NOUN
aiua-13762	7	9	is	be	AUX
aiua-13762	7	10	increased	increase	VERB
aiua-13762	7	11	by	by	ADP
aiua-13762	7	12	2.2	2.2	NUM
aiua-13762	7	13	-	-	NOUN
aiua-13762	7	14	fold	fold	ADJ
aiua-13762	7	15	and	and	CCONJ
aiua-13762	7	16	1.8	1.8	NUM
aiua-13762	7	17	-	-	NOUN
aiua-13762	7	18	fold	fold	ADJ
aiua-13762	7	19	,	,	PUNCT
aiua-13762	7	20	respectively	respectively	ADV
aiua-13762	7	21	(	(	PUNCT
aiua-13762	7	22	6	6	NUM
aiua-13762	7	23	,	,	PUNCT
aiua-13762	7	24	7	7	NUM
aiua-13762	7	25	)	)	PUNCT
aiua-13762	7	26	.	.	PUNCT
aiua-13762	8	1	notably	notably	ADV
aiua-13762	8	2	,	,	PUNCT
aiua-13762	8	3	pca	pca	PROPN
aiua-13762	8	4	has	have	AUX
aiua-13762	8	5	been	be	AUX
aiua-13762	8	6	observed	observe	VERB
aiua-13762	8	7	with	with	ADP
aiua-13762	8	8	increased	increase	VERB
aiua-13762	8	9	frequency	frequency	NOUN
aiua-13762	8	10	in	in	ADP
aiua-13762	8	11	families	family	NOUN
aiua-13762	8	12	affected	affect	VERB
aiua-13762	8	13	by	by	ADP
aiua-13762	8	14	the	the	DET
aiua-13762	8	15	hereditary	hereditary	ADJ
aiua-13762	8	16	breast	breast	NOUN
aiua-13762	8	17	and	and	CCONJ
aiua-13762	8	18	ovarian	ovarian	ADJ
aiua-13762	8	19	cancer	cancer	NOUN
aiua-13762	8	20	(	(	PUNCT
aiua-13762	8	21	hboc	hboc	NOUN
aiua-13762	8	22	)	)	PUNCT
aiua-13762	8	23	syndrome	syndrome	NOUN
aiua-13762	8	24	.	.	PUNCT
aiua-13762	9	1	additionally	additionally	ADV
aiua-13762	9	2	,	,	PUNCT
aiua-13762	9	3	a	a	DET
aiua-13762	9	4	family	family	NOUN
aiua-13762	9	5	history	history	NOUN
aiua-13762	9	6	of	of	ADP
aiua-13762	9	7	prostate	prostate	NOUN
aiua-13762	9	8	cancer	cancer	NOUN
aiua-13762	9	9	among	among	ADP
aiua-13762	9	10	first	first	ADJ
aiua-13762	9	11	-	-	PUNCT
aiua-13762	9	12	degree	degree	NOUN
aiua-13762	9	13	relatives	relative	NOUN
aiua-13762	9	14	has	have	AUX
aiua-13762	9	15	been	be	AUX
aiua-13762	9	16	correlated	correlate	VERB
aiua-13762	9	17	with	with	ADP
aiua-13762	9	18	an	an	DET
aiua-13762	9	19	elevated	elevated	ADJ
aiua-13762	9	20	risk	risk	NOUN
aiua-13762	9	21	of	of	ADP
aiua-13762	9	22	breast	breast	NOUN
aiua-13762	9	23	cancer	cancer	NOUN
aiua-13762	9	24	in	in	ADP
aiua-13762	9	25	women	woman	NOUN
aiua-13762	9	26	(	(	PUNCT
aiua-13762	9	27	8)	8)	NUM
aiua-13762	9	28	.	.	PUNCT
aiua-13762	10	1	if	if	SCONJ
aiua-13762	10	2	familial	familial	ADJ
aiua-13762	10	3	clustering	clustering	NOUN
aiua-13762	10	4	is	be	AUX
aiua-13762	10	5	recognized	recognize	VERB
aiua-13762	10	6	as	as	ADP
aiua-13762	10	7	a	a	DET
aiua-13762	10	8	critical	critical	ADJ
aiua-13762	10	9	risk	risk	NOUN
aiua-13762	10	10	factor	factor	NOUN
aiua-13762	10	11	for	for	ADP
aiua-13762	10	12	pca	pca	PROPN
aiua-13762	10	13	,	,	PUNCT
aiua-13762	10	14	genetic	genetic	ADJ
aiua-13762	10	15	bottlenecks	bottleneck	NOUN
aiua-13762	10	16	might	might	AUX
aiua-13762	10	17	further	far	ADV
aiua-13762	10	18	enhance	enhance	VERB
aiua-13762	10	19	the	the	DET
aiua-13762	10	20	likelihood	likelihood	NOUN
aiua-13762	10	21	of	of	ADP
aiua-13762	10	22	transmitting	transmit	VERB
aiua-13762	10	23	mutations	mutation	NOUN
aiua-13762	10	24	within	within	ADP
aiua-13762	10	25	specific	specific	ADJ
aiua-13762	10	26	genes	gene	NOUN
aiua-13762	10	27	within	within	ADP
aiua-13762	10	28	a	a	DET
aiua-13762	10	29	population	population	NOUN
aiua-13762	10	30	.	.	PUNCT
aiua-13762	11	1	populations	population	NOUN
aiua-13762	11	2	with	with	ADP
aiua-13762	11	3	high	high	ADJ
aiua-13762	11	4	levels	level	NOUN
aiua-13762	11	5	of	of	ADP
aiua-13762	11	6	endogamy	endogamy	NOUN
aiua-13762	11	7	,	,	PUNCT
aiua-13762	11	8	resulting	result	VERB
aiua-13762	11	9	from	from	ADP
aiua-13762	11	10	consanguineous	consanguineous	ADJ
aiua-13762	11	11	unions	union	NOUN
aiua-13762	11	12	or	or	CCONJ
aiua-13762	11	13	marriages	marriage	NOUN
aiua-13762	11	14	among	among	ADP
aiua-13762	11	15	relatives	relative	NOUN
aiua-13762	11	16	,	,	PUNCT
aiua-13762	11	17	exhibit	exhibit	VERB
aiua-13762	11	18	a	a	DET
aiua-13762	11	19	greater	great	ADJ
aiua-13762	11	20	propensity	propensity	NOUN
aiua-13762	11	21	for	for	ADP
aiua-13762	11	22	developing	develop	VERB
aiua-13762	11	23	autosomal	autosomal	ADJ
aiua-13762	11	24	recessive	recessive	ADJ
aiua-13762	11	25	non	non	ADJ
aiua-13762	11	26	-	-	ADJ
aiua-13762	11	27	cancer	cancer	ADJ
aiua-13762	11	28	diseases	disease	NOUN
aiua-13762	11	29	and	and	CCONJ
aiua-13762	11	30	cancers	cancer	NOUN
aiua-13762	11	31	,	,	PUNCT
aiua-13762	11	32	compared	compare	VERB
aiua-13762	11	33	to	to	ADP
aiua-13762	11	34	non	non	ADJ
aiua-13762	11	35	-	-	ADJ
aiua-13762	11	36	endogamous	endogamous	ADJ
aiua-13762	11	37	populations	population	NOUN
aiua-13762	11	38	.	.	PUNCT
aiua-13762	12	1	for	for	ADP
aiua-13762	12	2	example	example	NOUN
aiua-13762	12	3	,	,	PUNCT
aiua-13762	12	4	in	in	ADP
aiua-13762	12	5	the	the	DET
aiua-13762	12	6	icelandic	icelandic	ADJ
aiua-13762	12	7	population	population	NOUN
aiua-13762	12	8	,	,	PUNCT
aiua-13762	12	9	historically	historically	ADV
aiua-13762	12	10	characterized	characterize	VERB
aiua-13762	12	11	by	by	ADP
aiua-13762	12	12	significant	significant	ADJ
aiua-13762	12	13	kinship	kinship	NOUN
aiua-13762	12	14	,	,	PUNCT
aiua-13762	12	15	the	the	DET
aiua-13762	12	16	999del5	999del5	NUM
aiua-13762	12	17	founder	founder	NOUN
aiua-13762	12	18	mutation	mutation	NOUN
aiua-13762	12	19	in	in	ADP
aiua-13762	12	20	the	the	DET
aiua-13762	12	21	brca2	brca2	NOUN
aiua-13762	12	22	gene	gene	NOUN
aiua-13762	12	23	,	,	PUNCT
aiua-13762	12	24	which	which	PRON
aiua-13762	12	25	accounts	account	VERB
aiua-13762	12	26	for	for	ADP
aiua-13762	12	27	7	7	NUM
aiua-13762	12	28	-	-	SYM
aiua-13762	12	29	8	8	NUM
aiua-13762	12	30	%	%	NOUN
aiua-13762	12	31	of	of	ADP
aiua-13762	12	32	female	female	ADJ
aiua-13762	12	33	breast	breast	NOUN
aiua-13762	12	34	cancers	cancer	NOUN
aiua-13762	12	35	and	and	CCONJ
aiua-13762	12	36	40	40	NUM
aiua-13762	12	37	%	%	NOUN
aiua-13762	12	38	of	of	ADP
aiua-13762	12	39	male	male	ADJ
aiua-13762	12	40	breast	breast	NOUN
aiua-13762	12	41	cancers	cancer	NOUN
aiua-13762	12	42	,	,	PUNCT
aiua-13762	12	43	is	be	AUX
aiua-13762	12	44	strongly	strongly	ADV
aiua-13762	12	45	associated	associate	VERB
aiua-13762	12	46	with	with	ADP
aiua-13762	12	47	a	a	DET
aiua-13762	12	48	highly	highly	ADV
aiua-13762	12	49	aggressive	aggressive	ADJ
aiua-13762	12	50	form	form	NOUN
aiua-13762	12	51	of	of	ADP
aiua-13762	12	52	lethal	lethal	ADJ
aiua-13762	12	53	prostate	prostate	NOUN
aiua-13762	12	54	cancer	cancer	NOUN
aiua-13762	12	55	(	(	PUNCT
aiua-13762	12	56	hazard	hazard	NOUN
aiua-13762	12	57	ratio	ratio	NOUN
aiua-13762	12	58	,	,	PUNCT
aiua-13762	12	59	3.64	3.64	NUM
aiua-13762	12	60	,	,	PUNCT
aiua-13762	12	61	95	95	NUM
aiua-13762	12	62	%	%	NOUN
aiua-13762	12	63	ci	ci	NOUN
aiua-13762	12	64	,	,	PUNCT
aiua-13762	12	65	2.29	2.29	NUM
aiua-13762	12	66	-	-	SYM
aiua-13762	12	67	5.78	5.78	NUM
aiua-13762	12	68	)	)	PUNCT
aiua-13762	12	69	(	(	PUNCT
aiua-13762	12	70	9	9	NUM
aiua-13762	12	71	)	)	PUNCT
aiua-13762	12	72	.	.	PUNCT
aiua-13762	13	1	ashkenazi	ashkenazi	ADJ
aiua-13762	13	2	jews	jews	PROPN
aiua-13762	13	3	(	(	PUNCT
aiua-13762	13	4	aj	aj	PROPN
aiua-13762	13	5	)	)	PUNCT
aiua-13762	13	6	,	,	PUNCT
aiua-13762	13	7	or	or	CCONJ
aiua-13762	13	8	ashkenazim	ashkenazim	NOUN
aiua-13762	13	9	,	,	PUNCT
aiua-13762	13	10	are	be	AUX
aiua-13762	13	11	a	a	DET
aiua-13762	13	12	diaspora	diaspora	ADJ
aiua-13762	13	13	population	population	NOUN
aiua-13762	13	14	that	that	PRON
aiua-13762	13	15	consolidated	consolidate	VERB
aiua-13762	13	16	toward	toward	ADP
aiua-13762	13	17	the	the	DET
aiua-13762	13	18	end	end	NOUN
aiua-13762	13	19	of	of	ADP
aiua-13762	13	20	the	the	DET
aiua-13762	13	21	first	first	ADJ
aiua-13762	13	22	milbackground	milbackground	NOUN
aiua-13762	13	23	:	:	PUNCT
aiua-13762	13	24	prostate	prostate	NOUN
aiua-13762	13	25	cancer	cancer	NOUN
aiua-13762	13	26	(	(	PUNCT
aiua-13762	13	27	pca	pca	PROPN
aiua-13762	13	28	)	)	PUNCT
aiua-13762	13	29	is	be	AUX
aiua-13762	13	30	the	the	DET
aiua-13762	13	31	most	most	ADV
aiua-13762	13	32	prevalent	prevalent	ADJ
aiua-13762	13	33	cancer	cancer	NOUN
aiua-13762	13	34	among	among	ADP
aiua-13762	13	35	men	man	NOUN
aiua-13762	13	36	in	in	ADP
aiua-13762	13	37	the	the	DET
aiua-13762	13	38	european	european	PROPN
aiua-13762	13	39	union	union	PROPN
aiua-13762	13	40	,	,	PUNCT
aiua-13762	13	41	the	the	DET
aiua-13762	13	42	usa	usa	PROPN
aiua-13762	13	43	and	and	CCONJ
aiua-13762	13	44	israel	israel	PROPN
aiua-13762	13	45	,	,	PUNCT
aiua-13762	13	46	with	with	ADP
aiua-13762	13	47	heritability	heritability	NOUN
aiua-13762	13	48	being	be	AUX
aiua-13762	13	49	a	a	DET
aiua-13762	13	50	key	key	ADJ
aiua-13762	13	51	risk	risk	NOUN
aiua-13762	13	52	factor	factor	NOUN
aiua-13762	13	53	.	.	PUNCT
aiua-13762	14	1	endogamy	endogamy	NOUN
aiua-13762	14	2	and	and	CCONJ
aiua-13762	14	3	kinship	kinship	NOUN
aiua-13762	14	4	are	be	AUX
aiua-13762	14	5	known	know	VERB
aiua-13762	14	6	to	to	PART
aiua-13762	14	7	increase	increase	VERB
aiua-13762	14	8	the	the	DET
aiua-13762	14	9	likelihood	likelihood	NOUN
aiua-13762	14	10	of	of	ADP
aiua-13762	14	11	transmitting	transmit	VERB
aiua-13762	14	12	genetic	genetic	ADJ
aiua-13762	14	13	mutations	mutation	NOUN
aiua-13762	14	14	associated	associate	VERB
aiua-13762	14	15	with	with	ADP
aiua-13762	14	16	various	various	ADJ
aiua-13762	14	17	cancers	cancer	NOUN
aiua-13762	14	18	,	,	PUNCT
aiua-13762	14	19	as	as	SCONJ
aiua-13762	14	20	seen	see	VERB
aiua-13762	14	21	in	in	ADP
aiua-13762	14	22	populations	population	NOUN
aiua-13762	14	23	with	with	ADP
aiua-13762	14	24	high	high	ADJ
aiua-13762	14	25	levels	level	NOUN
aiua-13762	14	26	of	of	ADP
aiua-13762	14	27	consanguinity	consanguinity	NOUN
aiua-13762	14	28	,	,	PUNCT
aiua-13762	14	29	such	such	ADJ
aiua-13762	14	30	as	as	ADP
aiua-13762	14	31	ashkenazi	ashkenazi	ADJ
aiua-13762	14	32	jews	jews	PROPN
aiua-13762	14	33	.	.	PUNCT
aiua-13762	15	1	the	the	DET
aiua-13762	15	2	ashkenazi	ashkenazi	ADJ
aiua-13762	15	3	jewish	jewish	ADJ
aiua-13762	15	4	population	population	NOUN
aiua-13762	15	5	,	,	PUNCT
aiua-13762	15	6	with	with	ADP
aiua-13762	15	7	a	a	DET
aiua-13762	15	8	history	history	NOUN
aiua-13762	15	9	of	of	ADP
aiua-13762	15	10	genetic	genetic	ADJ
aiua-13762	15	11	bottlenecks	bottleneck	NOUN
aiua-13762	15	12	and	and	CCONJ
aiua-13762	15	13	selective	selective	ADJ
aiua-13762	15	14	migrations	migration	NOUN
aiua-13762	15	15	,	,	PUNCT
aiua-13762	15	16	has	have	VERB
aiua-13762	15	17	a	a	DET
aiua-13762	15	18	higher	high	ADJ
aiua-13762	15	19	prevalence	prevalence	NOUN
aiua-13762	15	20	of	of	ADP
aiua-13762	15	21	inherited	inherit	VERB
aiua-13762	15	22	mutations	mutation	NOUN
aiua-13762	15	23	that	that	PRON
aiua-13762	15	24	predispose	predispose	VERB
aiua-13762	15	25	individuals	individual	NOUN
aiua-13762	15	26	to	to	ADP
aiua-13762	15	27	various	various	ADJ
aiua-13762	15	28	diseases	disease	NOUN
aiua-13762	15	29	including	include	VERB
aiua-13762	15	30	cancer	cancer	NOUN
aiua-13762	15	31	.	.	PUNCT
aiua-13762	16	1	this	this	DET
aiua-13762	16	2	article	article	NOUN
aiua-13762	16	3	reviews	review	VERB
aiua-13762	16	4	the	the	DET
aiua-13762	16	5	literature	literature	NOUN
aiua-13762	16	6	examining	examine	VERB
aiua-13762	16	7	the	the	DET
aiua-13762	16	8	potential	potential	ADJ
aiua-13762	16	9	effects	effect	NOUN
aiua-13762	16	10	of	of	ADP
aiua-13762	16	11	founder	founder	NOUN
aiua-13762	16	12	mutations	mutation	NOUN
aiua-13762	16	13	specific	specific	ADJ
aiua-13762	16	14	to	to	ADP
aiua-13762	16	15	ashkenazi	ashkenazi	ADJ
aiua-13762	16	16	jews	jews	PROPN
aiua-13762	16	17	,	,	PUNCT
aiua-13762	16	18	in	in	ADP
aiua-13762	16	19	enhancing	enhance	VERB
aiua-13762	16	20	the	the	DET
aiua-13762	16	21	genetic	genetic	ADJ
aiua-13762	16	22	risk	risk	NOUN
aiua-13762	16	23	of	of	ADP
aiua-13762	16	24	prostate	prostate	NOUN
aiua-13762	16	25	cancer	cancer	NOUN
aiua-13762	16	26	in	in	ADP
aiua-13762	16	27	this	this	DET
aiua-13762	16	28	population	population	NOUN
aiua-13762	16	29	.	.	PUNCT
aiua-13762	17	1	methods	method	NOUN
aiua-13762	17	2	:	:	PUNCT
aiua-13762	17	3	we	we	PRON
aiua-13762	17	4	searched	search	VERB
aiua-13762	17	5	for	for	ADP
aiua-13762	17	6	english	english	ADJ
aiua-13762	17	7	-	-	PUNCT
aiua-13762	17	8	language	language	NOUN
aiua-13762	17	9	articles	article	NOUN
aiua-13762	17	10	on	on	ADP
aiua-13762	17	11	dna	dna	PROPN
aiua-13762	17	12	mutations	mutation	NOUN
aiua-13762	17	13	in	in	ADP
aiua-13762	17	14	ashkenazi	ashkenazi	ADJ
aiua-13762	17	15	jewish	jewish	ADJ
aiua-13762	17	16	patients	patient	NOUN
aiua-13762	17	17	of	of	ADP
aiua-13762	17	18	any	any	DET
aiua-13762	17	19	age	age	NOUN
aiua-13762	17	20	with	with	ADP
aiua-13762	17	21	prostate	prostate	NOUN
aiua-13762	17	22	cancer	cancer	NOUN
aiua-13762	17	23	of	of	ADP
aiua-13762	17	24	any	any	DET
aiua-13762	17	25	grade	grade	NOUN
aiua-13762	17	26	,	,	PUNCT
aiua-13762	17	27	including	include	VERB
aiua-13762	17	28	various	various	ADJ
aiua-13762	17	29	study	study	NOUN
aiua-13762	17	30	types	type	NOUN
aiua-13762	17	31	,	,	PUNCT
aiua-13762	17	32	using	use	VERB
aiua-13762	17	33	pubmed	pubmed	PROPN
aiua-13762	17	34	and	and	CCONJ
aiua-13762	17	35	other	other	ADJ
aiua-13762	17	36	databases	database	NOUN
aiua-13762	17	37	with	with	ADP
aiua-13762	17	38	relevant	relevant	ADJ
aiua-13762	17	39	keywords	keyword	NOUN
aiua-13762	17	40	,	,	PUNCT
aiua-13762	17	41	and	and	CCONJ
aiua-13762	17	42	confirmed	confirm	VERB
aiua-13762	17	43	the	the	DET
aiua-13762	17	44	search	search	NOUN
aiua-13762	17	45	was	be	AUX
aiua-13762	17	46	up	up	ADP
aiua-13762	17	47	-	-	PUNCT
aiua-13762	17	48	to	to	ADP
aiua-13762	17	49	-	-	PUNCT
aiua-13762	17	50	date	date	NOUN
aiua-13762	17	51	as	as	ADP
aiua-13762	17	52	of	of	ADP
aiua-13762	17	53	january	january	PROPN
aiua-13762	17	54	31st	31st	NOUN
aiua-13762	17	55	,	,	PUNCT
aiua-13762	17	56	2025	2025	NUM
aiua-13762	17	57	.	.	PUNCT
aiua-13762	18	1	results	result	NOUN
aiua-13762	18	2	:	:	PUNCT
aiua-13762	18	3	while	while	SCONJ
aiua-13762	18	4	the	the	DET
aiua-13762	18	5	overall	overall	ADJ
aiua-13762	18	6	burden	burden	NOUN
aiua-13762	18	7	of	of	ADP
aiua-13762	18	8	pca	pca	NOUN
aiua-13762	18	9	may	may	AUX
aiua-13762	18	10	not	not	PART
aiua-13762	18	11	be	be	AUX
aiua-13762	18	12	higher	high	ADJ
aiua-13762	18	13	than	than	ADP
aiua-13762	18	14	in	in	ADP
aiua-13762	18	15	european	european	ADJ
aiua-13762	18	16	non	non	PROPN
aiua-13762	18	17	-	-	NOUN
aiua-13762	18	18	jews	jews	PROPN
aiua-13762	18	19	,	,	PUNCT
aiua-13762	18	20	certain	certain	ADJ
aiua-13762	18	21	founder	founder	NOUN
aiua-13762	18	22	mutations	mutation	NOUN
aiua-13762	18	23	in	in	ADP
aiua-13762	18	24	ashkenazi	ashkenazi	ADJ
aiua-13762	18	25	jews	jews	PROPN
aiua-13762	18	26	,	,	PUNCT
aiua-13762	18	27	especially	especially	ADV
aiua-13762	18	28	6174delt	6174delt	NUM
aiua-13762	18	29	in	in	ADP
aiua-13762	18	30	brca2	brca2	PROPN
aiua-13762	18	31	,	,	PUNCT
aiua-13762	18	32	are	be	AUX
aiua-13762	18	33	linked	link	VERB
aiua-13762	18	34	to	to	ADP
aiua-13762	18	35	increased	increase	VERB
aiua-13762	18	36	risk	risk	NOUN
aiua-13762	18	37	and	and	CCONJ
aiua-13762	18	38	aggressive	aggressive	ADJ
aiua-13762	18	39	forms	form	NOUN
aiua-13762	18	40	of	of	ADP
aiua-13762	18	41	pca	pca	PROPN
aiua-13762	18	42	.	.	PUNCT
aiua-13762	19	1	further	further	ADJ
aiua-13762	19	2	research	research	NOUN
aiua-13762	19	3	is	be	AUX
aiua-13762	19	4	needed	need	VERB
aiua-13762	19	5	to	to	PART
aiua-13762	19	6	ascertain	ascertain	VERB
aiua-13762	19	7	unequivocally	unequivocally	ADV
aiua-13762	19	8	the	the	DET
aiua-13762	19	9	potential	potential	ADJ
aiua-13762	19	10	predisposing	predispose	VERB
aiua-13762	19	11	role	role	NOUN
aiua-13762	19	12	of	of	ADP
aiua-13762	19	13	mutations	mutation	NOUN
aiua-13762	19	14	such	such	ADJ
aiua-13762	19	15	as	as	ADP
aiua-13762	19	16	185delag	185delag	PROPN
aiua-13762	19	17	in	in	ADP
aiua-13762	19	18	brca1	brca1	PROPN
aiua-13762	19	19	or	or	CCONJ
aiua-13762	19	20	471delaaag	471delaaag	PROPN
aiua-13762	19	21	in	in	ADP
aiua-13762	19	22	rnasel	rnasel	NOUN
aiua-13762	19	23	.	.	PUNCT
aiua-13762	20	1	conclusions	conclusion	NOUN
aiua-13762	20	2	:	:	PUNCT
aiua-13762	20	3	overall	overall	ADJ
aiua-13762	20	4	,	,	PUNCT
aiua-13762	20	5	genetic	genetic	ADJ
aiua-13762	20	6	screening	screening	NOUN
aiua-13762	20	7	for	for	ADP
aiua-13762	20	8	pca	pca	NOUN
aiua-13762	20	9	risk	risk	NOUN
aiua-13762	20	10	in	in	ADP
aiua-13762	20	11	ashkenazi	ashkenazi	ADJ
aiua-13762	20	12	jewish	jewish	ADJ
aiua-13762	20	13	men	man	NOUN
aiua-13762	20	14	,	,	PUNCT
aiua-13762	20	15	particularly	particularly	ADV
aiua-13762	20	16	within	within	ADP
aiua-13762	20	17	high	high	ADJ
aiua-13762	20	18	-	-	PUNCT
aiua-13762	20	19	endogamy	endogamy	NOUN
aiua-13762	20	20	subgroups	subgroup	NOUN
aiua-13762	20	21	(	(	PUNCT
aiua-13762	20	22	haredim	haredim	PROPN
aiua-13762	20	23	)	)	PUNCT
aiua-13762	20	24	,	,	PUNCT
aiua-13762	20	25	may	may	AUX
aiua-13762	20	26	be	be	AUX
aiua-13762	20	27	beneficial	beneficial	ADJ
aiua-13762	20	28	.	.	PUNCT
aiua-13762	21	1	increasing	increase	VERB
aiua-13762	21	2	awareness	awareness	NOUN
aiua-13762	21	3	of	of	ADP
aiua-13762	21	4	familial	familial	ADJ
aiua-13762	21	5	hereditary	hereditary	ADJ
aiua-13762	21	6	prostate	prostate	NOUN
aiua-13762	21	7	cancer	cancer	NOUN
aiua-13762	21	8	among	among	ADP
aiua-13762	21	9	ashkenazi	ashkenazi	ADJ
aiua-13762	21	10	men	man	NOUN
aiua-13762	21	11	and	and	CCONJ
aiua-13762	21	12	healthcare	healthcare	NOUN
aiua-13762	21	13	providers	provider	NOUN
aiua-13762	21	14	is	be	AUX
aiua-13762	21	15	also	also	ADV
aiua-13762	21	16	crucial	crucial	ADJ
aiua-13762	21	17	for	for	ADP
aiua-13762	21	18	early	early	ADJ
aiua-13762	21	19	detection	detection	NOUN
aiua-13762	21	20	and	and	CCONJ
aiua-13762	21	21	better	well	ADJ
aiua-13762	21	22	management	management	NOUN
aiua-13762	21	23	of	of	ADP
aiua-13762	21	24	the	the	DET
aiua-13762	21	25	condition	condition	NOUN
aiua-13762	21	26	.	.	PUNCT
aiua-13762	22	1	the	the	DET
aiua-13762	22	2	complexity	complexity	NOUN
aiua-13762	22	3	of	of	ADP
aiua-13762	22	4	pca	pca	PROPN
aiua-13762	22	5	genetics	genetic	NOUN
aiua-13762	22	6	in	in	ADP
aiua-13762	22	7	ashkenazim	ashkenazim	PROPN
aiua-13762	22	8	,	,	PUNCT
aiua-13762	22	9	including	include	VERB
aiua-13762	22	10	the	the	DET
aiua-13762	22	11	influence	influence	NOUN
aiua-13762	22	12	of	of	ADP
aiua-13762	22	13	multiple	multiple	ADJ
aiua-13762	22	14	low	low	ADJ
aiua-13762	22	15	-	-	PUNCT
aiua-13762	22	16	penetrance	penetrance	NOUN
aiua-13762	22	17	mutations	mutation	NOUN
aiua-13762	22	18	,	,	PUNCT
aiua-13762	22	19	the	the	DET
aiua-13762	22	20	possible	possible	ADJ
aiua-13762	22	21	confounding	confound	VERB
aiua-13762	22	22	factor	factor	NOUN
aiua-13762	22	23	of	of	ADP
aiua-13762	22	24	phenocopies	phenocopie	NOUN
aiua-13762	22	25	,	,	PUNCT
aiua-13762	22	26	and	and	CCONJ
aiua-13762	22	27	the	the	DET
aiua-13762	22	28	need	need	NOUN
aiua-13762	22	29	for	for	ADP
aiua-13762	22	30	larger	large	ADJ
aiua-13762	22	31	,	,	PUNCT
aiua-13762	22	32	more	more	ADV
aiua-13762	22	33	diverse	diverse	ADJ
aiua-13762	22	34	studies	study	NOUN
aiua-13762	22	35	,	,	PUNCT
aiua-13762	22	36	underscores	underscore	VERB
aiua-13762	22	37	the	the	DET
aiua-13762	22	38	challenges	challenge	NOUN
aiua-13762	22	39	in	in	ADP
aiua-13762	22	40	identifying	identify	VERB
aiua-13762	22	41	definitive	definitive	ADJ
aiua-13762	22	42	genetic	genetic	ADJ
aiua-13762	22	43	risk	risk	NOUN
aiua-13762	22	44	factors	factor	NOUN
aiua-13762	22	45	.	.	PUNCT
aiua-13762	23	1	further	further	ADJ
aiua-13762	23	2	studies	study	NOUN
aiua-13762	23	3	are	be	AUX
aiua-13762	23	4	awaited	await	VERB
aiua-13762	23	5	investigating	investigate	VERB
aiua-13762	23	6	in	in	ADP
aiua-13762	23	7	-	-	PUNCT
aiua-13762	23	8	depth	depth	NOUN
aiua-13762	23	9	the	the	DET
aiua-13762	23	10	aggressiveness	aggressiveness	NOUN
aiua-13762	23	11	and	and	CCONJ
aiua-13762	23	12	response	response	NOUN
aiua-13762	23	13	to	to	ADP
aiua-13762	23	14	treatment	treatment	NOUN
aiua-13762	23	15	of	of	ADP
aiua-13762	23	16	pc	pc	NOUN
aiua-13762	23	17	among	among	ADP
aiua-13762	23	18	ashkenazi	ashkenazi	ADJ
aiua-13762	23	19	jews	jews	PROPN
aiua-13762	23	20	.	.	PUNCT
aiua-13762	24	1	key	key	ADJ
aiua-13762	24	2	words	word	NOUN
aiua-13762	24	3	:	:	PUNCT
aiua-13762	24	4	prostate	prostate	NOUN
aiua-13762	24	5	cancer	cancer	NOUN
aiua-13762	24	6	;	;	PUNCT
aiua-13762	24	7	breast	breast	NOUN
aiua-13762	24	8	cancer	cancer	NOUN
aiua-13762	24	9	;	;	PUNCT
aiua-13762	24	10	ovarian	ovarian	ADJ
aiua-13762	24	11	cancer	cancer	NOUN
aiua-13762	24	12	;	;	PUNCT
aiua-13762	24	13	dna	dna	PROPN
aiua-13762	24	14	mutation	mutation	NOUN
aiua-13762	24	15	;	;	PUNCT
aiua-13762	24	16	jews	jews	PROPN
aiua-13762	24	17	;	;	PUNCT
aiua-13762	24	18	ashkenazi	ashkenazi	ADJ
aiua-13762	24	19	jews	jews	PROPN
aiua-13762	24	20	;	;	PUNCT
aiua-13762	24	21	endogamy	endogamy	PROPN
aiua-13762	24	22	.	.	PUNCT
aiua-13762	24	23	submitted	submit	VERB
aiua-13762	24	24	5	5	NUM
aiua-13762	24	25	march	march	NOUN
aiua-13762	24	26	2025	2025	NUM
aiua-13762	24	27	;	;	PUNCT
aiua-13762	24	28	accepted	accept	VERB
aiua-13762	24	29	24	24	NUM
aiua-13762	24	30	march	march	NOUN
aiua-13762	24	31	2025	2025	NUM
aiua-13762	24	32	genetic	genetic	ADJ
aiua-13762	24	33	determinants	determinant	NOUN
aiua-13762	24	34	of	of	ADP
aiua-13762	24	35	prostate	prostate	NOUN
aiua-13762	24	36	cancer	cancer	NOUN
aiua-13762	24	37	predisposition	predisposition	NOUN
aiua-13762	24	38	in	in	ADP
aiua-13762	24	39	ashkenazi	ashkenazi	ADJ
aiua-13762	24	40	jews	jews	PROPN
aiua-13762	24	41	gianpaolo	gianpaolo	VERB
aiua-13762	24	42	perletti	perletti	PROPN
aiua-13762	24	43	1	1	NUM
aiua-13762	24	44	,	,	PUNCT
aiua-13762	24	45	daniel	daniel	PROPN
aiua-13762	24	46	cohen	cohen	PROPN
aiua-13762	24	47	hattab	hattab	PROPN
aiua-13762	24	48	2	2	NUM
aiua-13762	24	49	,	,	PUNCT
aiua-13762	24	50	sergio	sergio	PROPN
aiua-13762	24	51	dellapergola	dellapergola	PROPN
aiua-13762	24	52	3	3	NUM
aiua-13762	24	53	,	,	PUNCT
aiua-13762	24	54	ofer	ofer	AUX
aiua-13762	24	55	gofrit	gofrit	NOUN
aiua-13762	24	56	4	4	NUM
aiua-13762	24	57	,	,	PUNCT
aiua-13762	24	58	vittorio	vittorio	NOUN
aiua-13762	24	59	magri	magri	NOUN
aiua-13762	24	60	5	5	NUM
aiua-13762	24	61	,	,	PUNCT
aiua-13762	24	62	alberto	alberto	X
aiua-13762	24	63	trinchieri	trinchieri	ADJ
aiua-13762	24	64	6	6	NUM
aiua-13762	24	65	1	1	NUM
aiua-13762	24	66	department	department	NOUN
aiua-13762	24	67	of	of	ADP
aiua-13762	24	68	biotechnology	biotechnology	NOUN
aiua-13762	24	69	and	and	CCONJ
aiua-13762	24	70	life	life	NOUN
aiua-13762	24	71	sciences	science	NOUN
aiua-13762	24	72	,	,	PUNCT
aiua-13762	24	73	section	section	NOUN
aiua-13762	24	74	of	of	ADP
aiua-13762	24	75	medical	medical	ADJ
aiua-13762	24	76	and	and	CCONJ
aiua-13762	24	77	surgical	surgical	ADJ
aiua-13762	24	78	sciences	science	NOUN
aiua-13762	24	79	,	,	PUNCT
aiua-13762	24	80	university	university	NOUN
aiua-13762	24	81	of	of	ADP
aiua-13762	24	82	insubria	insubria	PROPN
aiua-13762	24	83	,	,	PUNCT
aiua-13762	24	84	varese	varese	PROPN
aiua-13762	24	85	,	,	PUNCT
aiua-13762	24	86	italy	italy	PROPN
aiua-13762	24	87	;	;	PUNCT
aiua-13762	24	88	2	2	NUM
aiua-13762	24	89	faculty	faculty	NOUN
aiua-13762	24	90	of	of	ADP
aiua-13762	24	91	medicine	medicine	NOUN
aiua-13762	24	92	,	,	PUNCT
aiua-13762	24	93	the	the	DET
aiua-13762	24	94	hebrew	hebrew	ADJ
aiua-13762	24	95	university	university	PROPN
aiua-13762	24	96	of	of	ADP
aiua-13762	24	97	jerusalem	jerusalem	PROPN
aiua-13762	24	98	,	,	PUNCT
aiua-13762	24	99	israel	israel	PROPN
aiua-13762	24	100	;	;	PUNCT
aiua-13762	24	101	3	3	NUM
aiua-13762	24	102	the	the	DET
aiua-13762	24	103	harman	harman	PROPN
aiua-13762	24	104	institute	institute	PROPN
aiua-13762	24	105	of	of	ADP
aiua-13762	24	106	contemporary	contemporary	PROPN
aiua-13762	24	107	jewry	jewry	PROPN
aiua-13762	24	108	,	,	PUNCT
aiua-13762	24	109	the	the	DET
aiua-13762	24	110	hebrew	hebrew	ADJ
aiua-13762	24	111	university	university	PROPN
aiua-13762	24	112	of	of	ADP
aiua-13762	24	113	jerusalem	jerusalem	PROPN
aiua-13762	24	114	,	,	PUNCT
aiua-13762	24	115	israel	israel	PROPN
aiua-13762	24	116	;	;	PUNCT
aiua-13762	24	117	4	4	NUM
aiua-13762	24	118	department	department	NOUN
aiua-13762	24	119	of	of	ADP
aiua-13762	24	120	urology	urology	NOUN
aiua-13762	24	121	,	,	PUNCT
aiua-13762	24	122	hadassah	hadassah	PROPN
aiua-13762	24	123	hebrew	hebrew	PROPN
aiua-13762	24	124	university	university	PROPN
aiua-13762	24	125	hospital	hospital	NOUN
aiua-13762	24	126	,	,	PUNCT
aiua-13762	24	127	jerusalem	jerusalem	PROPN
aiua-13762	24	128	,	,	PUNCT
aiua-13762	24	129	israel	israel	PROPN
aiua-13762	24	130	;	;	PUNCT
aiua-13762	24	131	5	5	NUM
aiua-13762	24	132	urology	urology	NOUN
aiua-13762	24	133	clinic	clinic	NOUN
aiua-13762	24	134	,	,	PUNCT
aiua-13762	24	135	asst	asst	PROPN
aiua-13762	24	136	fatebenefratelli	fatebenefratelli	PROPN
aiua-13762	24	137	sacco	sacco	PROPN
aiua-13762	24	138	hospitals	hospitals	PROPN
aiua-13762	24	139	,	,	PUNCT
aiua-13762	24	140	milan	milan	PROPN
aiua-13762	24	141	,	,	PUNCT
aiua-13762	24	142	italy	italy	PROPN
aiua-13762	24	143	;	;	PUNCT
aiua-13762	24	144	6	6	NUM
aiua-13762	24	145	former	former	ADJ
aiua-13762	24	146	lecturer	lecturer	NOUN
aiua-13762	24	147	,	,	PUNCT
aiua-13762	24	148	school	school	NOUN
aiua-13762	24	149	of	of	ADP
aiua-13762	24	150	urology	urology	NOUN
aiua-13762	24	151	,	,	PUNCT
aiua-13762	24	152	university	university	PROPN
aiua-13762	24	153	of	of	ADP
aiua-13762	24	154	milan	milan	PROPN
aiua-13762	24	155	,	,	PUNCT
aiua-13762	24	156	milan	milan	PROPN
aiua-13762	24	157	,	,	PUNCT
aiua-13762	24	158	italy	italy	PROPN
aiua-13762	24	159	.	.	PUNCT
aiua-13762	25	1	doi	doi	PROPN
aiua-13762	25	2	:	:	PUNCT
aiua-13762	25	3	10.4081	10.4081	NUM
aiua-13762	25	4	/	/	SYM
aiua-13762	25	5	aiua.2025.13762	aiua.2025.13762	PROPN
aiua-13762	25	6	summary	summary	NOUN
aiua-13762	25	7	archivio	archivio	NOUN
aiua-13762	25	8	italiano	italiano	X
aiua-13762	25	9	di	di	X
aiua-13762	25	10	urologia	urologia	PROPN
aiua-13762	25	11	e	e	PROPN
aiua-13762	25	12	andrologia	andrologia	NOUN
aiua-13762	25	13	2025	2025	NUM
aiua-13762	25	14	;	;	PUNCT
aiua-13762	25	15	97(2):13762	97(2):13762	NUM
aiua-13762	25	16	g.	g.	PROPN
aiua-13762	25	17	perletti	perletti	PROPN
aiua-13762	25	18	,	,	PUNCT
aiua-13762	25	19	d.	d.	PROPN
aiua-13762	25	20	cohen	cohen	PROPN
aiua-13762	25	21	hattab	hattab	PROPN
aiua-13762	25	22	,	,	PUNCT
aiua-13762	25	23	s.	s.	PROPN
aiua-13762	25	24	dellapergola	dellapergola	PROPN
aiua-13762	25	25	,	,	PUNCT
aiua-13762	25	26	et	et	PROPN
aiua-13762	25	27	al	al	PROPN
aiua-13762	25	28	.	.	PROPN
aiua-13762	25	29	2	2	NUM
aiua-13762	25	30	lennium	lennium	PROPN
aiua-13762	25	31	c.e	c.e	PROPN
aiua-13762	25	32	.	.	PROPN
aiua-13762	25	33	,	,	PUNCT
aiua-13762	25	34	historically	historically	ADV
aiua-13762	25	35	inhabiting	inhabit	VERB
aiua-13762	25	36	regions	region	NOUN
aiua-13762	25	37	of	of	ADP
aiua-13762	25	38	central	central	ADJ
aiua-13762	25	39	and	and	CCONJ
aiua-13762	25	40	eastern	eastern	ADJ
aiua-13762	25	41	europe	europe	PROPN
aiua-13762	25	42	.	.	PUNCT
aiua-13762	26	1	some	some	PRON
aiua-13762	26	2	of	of	ADP
aiua-13762	26	3	the	the	DET
aiua-13762	26	4	founders	founder	NOUN
aiua-13762	26	5	were	be	AUX
aiua-13762	26	6	jewish	jewish	ADJ
aiua-13762	26	7	migrants	migrant	NOUN
aiua-13762	26	8	from	from	ADP
aiua-13762	26	9	southern	southern	ADJ
aiua-13762	26	10	european	european	ADJ
aiua-13762	26	11	regions	region	NOUN
aiua-13762	26	12	,	,	PUNCT
aiua-13762	26	13	namely	namely	ADV
aiua-13762	26	14	from	from	ADP
aiua-13762	26	15	southern	southern	PROPN
aiua-13762	26	16	italy	italy	PROPN
aiua-13762	26	17	,	,	PUNCT
aiua-13762	26	18	some	some	PRON
aiua-13762	26	19	of	of	ADP
aiua-13762	26	20	whom	whom	PRON
aiua-13762	26	21	in	in	ADP
aiua-13762	26	22	turn	turn	NOUN
aiua-13762	26	23	had	have	VERB
aiua-13762	26	24	more	more	ADV
aiua-13762	26	25	ancient	ancient	ADJ
aiua-13762	26	26	middle	middle	ADJ
aiua-13762	26	27	eastern	eastern	ADJ
aiua-13762	26	28	origins	origin	NOUN
aiua-13762	26	29	(	(	PUNCT
aiua-13762	26	30	10	10	NUM
aiua-13762	26	31	,	,	PUNCT
aiua-13762	26	32	11	11	NUM
aiua-13762	26	33	)	)	PUNCT
aiua-13762	26	34	.	.	PUNCT
aiua-13762	27	1	bottlenecks	bottleneck	NOUN
aiua-13762	27	2	were	be	AUX
aiua-13762	27	3	periodically	periodically	ADV
aiua-13762	27	4	generated	generate	VERB
aiua-13762	27	5	due	due	ADP
aiua-13762	27	6	to	to	ADP
aiua-13762	27	7	selective	selective	ADJ
aiua-13762	27	8	migrations	migration	NOUN
aiua-13762	27	9	and	and	CCONJ
aiua-13762	27	10	to	to	ADP
aiua-13762	27	11	repeated	repeat	VERB
aiua-13762	27	12	cases	case	NOUN
aiua-13762	27	13	of	of	ADP
aiua-13762	27	14	drastic	drastic	ADJ
aiua-13762	27	15	jewish	jewish	ADJ
aiua-13762	27	16	population	population	NOUN
aiua-13762	27	17	reductions	reduction	NOUN
aiua-13762	27	18	following	follow	VERB
aiua-13762	27	19	massacres	massacre	NOUN
aiua-13762	27	20	of	of	ADP
aiua-13762	27	21	entire	entire	ADJ
aiua-13762	27	22	communities	community	NOUN
aiua-13762	27	23	.	.	PUNCT
aiua-13762	28	1	these	these	DET
aiua-13762	28	2	reductions	reduction	NOUN
aiua-13762	28	3	were	be	AUX
aiua-13762	28	4	followed	follow	VERB
aiua-13762	28	5	by	by	ADP
aiua-13762	28	6	periods	period	NOUN
aiua-13762	28	7	of	of	ADP
aiua-13762	28	8	rapid	rapid	ADJ
aiua-13762	28	9	expansion	expansion	NOUN
aiua-13762	28	10	due	due	ADP
aiua-13762	28	11	to	to	ADP
aiua-13762	28	12	high	high	ADJ
aiua-13762	28	13	fertility	fertility	NOUN
aiua-13762	28	14	and	and	CCONJ
aiua-13762	28	15	sometimes	sometimes	ADV
aiua-13762	28	16	higher	high	ADJ
aiua-13762	28	17	-	-	PUNCT
aiua-13762	28	18	than	than	ADP
aiua-13762	28	19	-	-	PUNCT
aiua-13762	28	20	average	average	ADJ
aiua-13762	28	21	life	life	NOUN
aiua-13762	28	22	expectancies	expectancy	NOUN
aiua-13762	28	23	among	among	ADP
aiua-13762	28	24	jewish	jewish	ADJ
aiua-13762	28	25	populations	population	NOUN
aiua-13762	28	26	(	(	PUNCT
aiua-13762	28	27	12	12	NUM
aiua-13762	28	28	-	-	SYM
aiua-13762	28	29	14	14	NUM
aiua-13762	28	30	)	)	PUNCT
aiua-13762	28	31	.	.	PUNCT
aiua-13762	29	1	the	the	DET
aiua-13762	29	2	ashkenazi	ashkenazi	ADJ
aiua-13762	29	3	population	population	NOUN
aiua-13762	29	4	,	,	PUNCT
aiua-13762	29	5	initially	initially	ADV
aiua-13762	29	6	estimated	estimate	VERB
aiua-13762	29	7	to	to	PART
aiua-13762	29	8	number	number	VERB
aiua-13762	29	9	a	a	DET
aiua-13762	29	10	few	few	ADJ
aiua-13762	29	11	tens	ten	NOUN
aiua-13762	29	12	of	of	ADP
aiua-13762	29	13	thousands	thousand	NOUN
aiua-13762	29	14	at	at	ADP
aiua-13762	29	15	the	the	DET
aiua-13762	29	16	end	end	NOUN
aiua-13762	29	17	of	of	ADP
aiua-13762	29	18	the	the	DET
aiua-13762	29	19	12th	12th	ADJ
aiua-13762	29	20	century	century	NOUN
aiua-13762	29	21	,	,	PUNCT
aiua-13762	29	22	grew	grow	VERB
aiua-13762	29	23	to	to	ADP
aiua-13762	29	24	over	over	ADP
aiua-13762	29	25	9.5	9.5	NUM
aiua-13762	29	26	million	million	NUM
aiua-13762	29	27	by	by	ADP
aiua-13762	29	28	1939	1939	NUM
aiua-13762	29	29	.	.	PUNCT
aiua-13762	30	1	following	follow	VERB
aiua-13762	30	2	the	the	DET
aiua-13762	30	3	killing	killing	NOUN
aiua-13762	30	4	of	of	ADP
aiua-13762	30	5	approximately	approximately	ADV
aiua-13762	30	6	6	6	NUM
aiua-13762	30	7	million	million	NUM
aiua-13762	30	8	ashkenazim	ashkenazim	NOUN
aiua-13762	30	9	during	during	ADP
aiua-13762	30	10	world	world	PROPN
aiua-13762	30	11	war	war	PROPN
aiua-13762	30	12	ii	ii	PROPN
aiua-13762	30	13	,	,	PUNCT
aiua-13762	30	14	an	an	DET
aiua-13762	30	15	estimated	estimate	VERB
aiua-13762	30	16	56	56	NUM
aiua-13762	30	17	million	million	NUM
aiua-13762	30	18	ashkenazim	ashkenazim	NOUN
aiua-13762	30	19	currently	currently	ADV
aiua-13762	30	20	reside	reside	VERB
aiua-13762	30	21	in	in	ADP
aiua-13762	30	22	the	the	DET
aiua-13762	30	23	usa	usa	PROPN
aiua-13762	30	24	,	,	PUNCT
aiua-13762	30	25	over	over	ADP
aiua-13762	30	26	3	3	NUM
aiua-13762	30	27	million	million	NUM
aiua-13762	30	28	in	in	ADP
aiua-13762	30	29	israel	israel	PROPN
aiua-13762	30	30	,	,	PUNCT
aiua-13762	30	31	and	and	CCONJ
aiua-13762	30	32	over	over	ADP
aiua-13762	30	33	a	a	DET
aiua-13762	30	34	million	million	NUM
aiua-13762	30	35	in	in	ADP
aiua-13762	30	36	europe	europe	PROPN
aiua-13762	30	37	,	,	PUNCT
aiua-13762	30	38	south	south	PROPN
aiua-13762	30	39	america	america	PROPN
aiua-13762	30	40	,	,	PUNCT
aiua-13762	30	41	and	and	CCONJ
aiua-13762	30	42	other	other	ADJ
aiua-13762	30	43	regions	region	NOUN
aiua-13762	30	44	worldwide	worldwide	ADV
aiua-13762	30	45	(	(	PUNCT
aiua-13762	30	46	15	15	NUM
aiua-13762	30	47	)	)	PUNCT
aiua-13762	30	48	.	.	PUNCT
aiua-13762	31	1	the	the	DET
aiua-13762	31	2	high	high	ADJ
aiua-13762	31	3	degree	degree	NOUN
aiua-13762	31	4	of	of	ADP
aiua-13762	31	5	endogamy	endogamy	NOUN
aiua-13762	31	6	historically	historically	ADV
aiua-13762	31	7	prevalent	prevalent	ADJ
aiua-13762	31	8	among	among	ADP
aiua-13762	31	9	ashkenazim	ashkenazim	PROPN
aiua-13762	31	10	has	have	AUX
aiua-13762	31	11	significantly	significantly	ADV
aiua-13762	31	12	contributed	contribute	VERB
aiua-13762	31	13	to	to	ADP
aiua-13762	31	14	elevated	elevated	ADJ
aiua-13762	31	15	rates	rate	NOUN
aiua-13762	31	16	of	of	ADP
aiua-13762	31	17	genetically	genetically	ADV
aiua-13762	31	18	transmitted	transmit	VERB
aiua-13762	31	19	diseases	disease	NOUN
aiua-13762	31	20	,	,	PUNCT
aiua-13762	31	21	including	include	VERB
aiua-13762	31	22	tay	tay	NOUN
aiua-13762	31	23	-	-	PUNCT
aiua-13762	31	24	sachs	sachs	NOUN
aiua-13762	31	25	disease	disease	NOUN
aiua-13762	31	26	,	,	PUNCT
aiua-13762	31	27	familial	familial	ADJ
aiua-13762	31	28	dysautonomia	dysautonomia	NOUN
aiua-13762	31	29	,	,	PUNCT
aiua-13762	31	30	gaucher	gaucher	PROPN
aiua-13762	31	31	's	's	PART
aiua-13762	31	32	disease	disease	NOUN
aiua-13762	31	33	,	,	PUNCT
aiua-13762	31	34	bloom	bloom	NOUN
aiua-13762	31	35	syndrome	syndrome	NOUN
aiua-13762	31	36	,	,	PUNCT
aiua-13762	31	37	cystic	cystic	ADJ
aiua-13762	31	38	fibrosis	fibrosis	NOUN
aiua-13762	31	39	and	and	CCONJ
aiua-13762	31	40	others	other	NOUN
aiua-13762	31	41	(	(	PUNCT
aiua-13762	31	42	16	16	NUM
aiua-13762	31	43	,	,	PUNCT
aiua-13762	31	44	17	17	NUM
aiua-13762	31	45	)	)	PUNCT
aiua-13762	31	46	.	.	PUNCT
aiua-13762	32	1	with	with	ADP
aiua-13762	32	2	respect	respect	NOUN
aiua-13762	32	3	to	to	ADP
aiua-13762	32	4	neoplastic	neoplastic	ADJ
aiua-13762	32	5	diseases	disease	NOUN
aiua-13762	32	6	,	,	PUNCT
aiua-13762	32	7	non	non	ADJ
aiua-13762	32	8	-	-	ADJ
aiua-13762	32	9	hodgkin	hodgkin	NOUN
aiua-13762	32	10	's	's	PART
aiua-13762	32	11	lymphoma	lymphoma	NOUN
aiua-13762	32	12	,	,	PUNCT
aiua-13762	32	13	as	as	ADV
aiua-13762	32	14	well	well	ADV
aiua-13762	32	15	as	as	ADP
aiua-13762	32	16	ovarian	ovarian	ADJ
aiua-13762	32	17	,	,	PUNCT
aiua-13762	32	18	pancreatic	pancreatic	ADJ
aiua-13762	32	19	,	,	PUNCT
aiua-13762	32	20	and	and	CCONJ
aiua-13762	32	21	stomach	stomach	NOUN
aiua-13762	32	22	cancers	cancer	NOUN
aiua-13762	32	23	,	,	PUNCT
aiua-13762	32	24	exhibit	exhibit	VERB
aiua-13762	32	25	higher	high	ADJ
aiua-13762	32	26	incidence	incidence	NOUN
aiua-13762	32	27	rates	rate	NOUN
aiua-13762	32	28	among	among	ADP
aiua-13762	32	29	ashkenazim	ashkenazim	NOUN
aiua-13762	32	30	compared	compare	VERB
aiua-13762	32	31	to	to	ADP
aiua-13762	32	32	non	non	ADJ
aiua-13762	32	33	-	-	ADJ
aiua-13762	32	34	jewish	jewish	ADJ
aiua-13762	32	35	populations	population	NOUN
aiua-13762	32	36	(	(	PUNCT
aiua-13762	32	37	18	18	NUM
aiua-13762	32	38	,	,	PUNCT
aiua-13762	32	39	19	19	NUM
aiua-13762	32	40	)	)	PUNCT
aiua-13762	32	41	.	.	PUNCT
aiua-13762	33	1	in	in	ADP
aiua-13762	33	2	relation	relation	NOUN
aiua-13762	33	3	to	to	ADP
aiua-13762	33	4	breast	breast	NOUN
aiua-13762	33	5	cancer	cancer	NOUN
aiua-13762	33	6	,	,	PUNCT
aiua-13762	33	7	one	one	NUM
aiua-13762	33	8	in	in	ADP
aiua-13762	33	9	ten	ten	NUM
aiua-13762	33	10	ashkenazi	ashkenazi	ADJ
aiua-13762	33	11	jewish	jewish	ADJ
aiua-13762	33	12	women	woman	NOUN
aiua-13762	33	13	diagnosed	diagnose	VERB
aiua-13762	33	14	at	at	ADP
aiua-13762	33	15	any	any	DET
aiua-13762	33	16	age	age	NOUN
aiua-13762	33	17	carries	carry	VERB
aiua-13762	33	18	brca1	brca1	PROPN
aiua-13762	33	19	or	or	CCONJ
aiua-13762	33	20	brca2	brca2	NOUN
aiua-13762	33	21	inherited	inherit	VERB
aiua-13762	33	22	mutations	mutation	NOUN
aiua-13762	33	23	,	,	PUNCT
aiua-13762	33	24	which	which	PRON
aiua-13762	33	25	are	be	AUX
aiua-13762	33	26	comparatively	comparatively	ADV
aiua-13762	33	27	less	less	ADV
aiua-13762	33	28	frequently	frequently	ADV
aiua-13762	33	29	found	find	VERB
aiua-13762	33	30	in	in	ADP
aiua-13762	33	31	the	the	DET
aiua-13762	33	32	general	general	ADJ
aiua-13762	33	33	population	population	NOUN
aiua-13762	33	34	(	(	PUNCT
aiua-13762	33	35	approximately	approximately	ADV
aiua-13762	33	36	1	1	NUM
aiua-13762	33	37	in	in	ADP
aiua-13762	33	38	50	50	NUM
aiua-13762	33	39	)	)	PUNCT
aiua-13762	33	40	(	(	PUNCT
aiua-13762	33	41	20	20	NUM
aiua-13762	33	42	)	)	PUNCT
aiua-13762	33	43	.	.	PUNCT
aiua-13762	34	1	the	the	DET
aiua-13762	34	2	role	role	NOUN
aiua-13762	34	3	of	of	ADP
aiua-13762	34	4	inherited	inherit	VERB
aiua-13762	34	5	mutations	mutation	NOUN
aiua-13762	34	6	predisposing	predispose	VERB
aiua-13762	34	7	ashkenazim	ashkenazim	PRON
aiua-13762	34	8	to	to	ADP
aiua-13762	34	9	pca	pca	PROPN
aiua-13762	34	10	remains	remain	VERB
aiua-13762	34	11	controversial	controversial	ADJ
aiua-13762	34	12	.	.	PUNCT
aiua-13762	35	1	whereas	whereas	SCONJ
aiua-13762	35	2	it	it	PRON
aiua-13762	35	3	is	be	AUX
aiua-13762	35	4	becoming	become	VERB
aiua-13762	35	5	increasingly	increasingly	ADV
aiua-13762	35	6	evident	evident	ADJ
aiua-13762	35	7	that	that	SCONJ
aiua-13762	35	8	mutations	mutation	NOUN
aiua-13762	35	9	that	that	PRON
aiua-13762	35	10	predispose	predispose	VERB
aiua-13762	35	11	aj	aj	PROPN
aiua-13762	35	12	to	to	ADP
aiua-13762	35	13	various	various	ADJ
aiua-13762	35	14	cancers	cancer	NOUN
aiua-13762	35	15	(	(	PUNCT
aiua-13762	35	16	e.g.	e.g.	ADV
aiua-13762	35	17	,	,	PUNCT
aiua-13762	35	18	breast	breast	NOUN
aiua-13762	35	19	cancer	cancer	NOUN
aiua-13762	35	20	)	)	PUNCT
aiua-13762	35	21	may	may	AUX
aiua-13762	35	22	also	also	ADV
aiua-13762	35	23	increase	increase	VERB
aiua-13762	35	24	susceptibility	susceptibility	NOUN
aiua-13762	35	25	to	to	ADP
aiua-13762	35	26	prostate	prostate	NOUN
aiua-13762	35	27	cancer	cancer	NOUN
aiua-13762	35	28	,	,	PUNCT
aiua-13762	35	29	it	it	PRON
aiua-13762	35	30	is	be	AUX
aiua-13762	35	31	unclear	unclear	ADJ
aiua-13762	35	32	whether	whether	SCONJ
aiua-13762	35	33	ashkenazim	ashkenazim	PRON
aiua-13762	35	34	have	have	VERB
aiua-13762	35	35	a	a	DET
aiua-13762	35	36	higher	high	ADJ
aiua-13762	35	37	burden	burden	NOUN
aiua-13762	35	38	of	of	ADP
aiua-13762	35	39	pca	pca	NOUN
aiua-13762	35	40	than	than	ADP
aiua-13762	35	41	non	non	ADJ
aiua-13762	35	42	-	-	ADJ
aiua-13762	35	43	jewish	jewish	ADJ
aiua-13762	35	44	populations	population	NOUN
aiua-13762	35	45	.	.	PUNCT
aiua-13762	36	1	additionally	additionally	ADV
aiua-13762	36	2	,	,	PUNCT
aiua-13762	36	3	it	it	PRON
aiua-13762	36	4	is	be	AUX
aiua-13762	36	5	uncertain	uncertain	ADJ
aiua-13762	36	6	whether	whether	SCONJ
aiua-13762	36	7	pcapredisposing	pcapredisposing	NOUN
aiua-13762	36	8	mutations	mutation	NOUN
aiua-13762	36	9	demonstrate	demonstrate	VERB
aiua-13762	36	10	increased	increase	VERB
aiua-13762	36	11	penetrance	penetrance	NOUN
aiua-13762	36	12	in	in	ADP
aiua-13762	36	13	this	this	DET
aiua-13762	36	14	population	population	NOUN
aiua-13762	36	15	.	.	PUNCT
aiua-13762	37	1	the	the	DET
aiua-13762	37	2	objective	objective	NOUN
aiua-13762	37	3	of	of	ADP
aiua-13762	37	4	this	this	DET
aiua-13762	37	5	article	article	NOUN
aiua-13762	37	6	is	be	AUX
aiua-13762	37	7	to	to	PART
aiua-13762	37	8	systematically	systematically	ADV
aiua-13762	37	9	review	review	VERB
aiua-13762	37	10	the	the	DET
aiua-13762	37	11	existing	exist	VERB
aiua-13762	37	12	literature	literature	NOUN
aiua-13762	37	13	on	on	ADP
aiua-13762	37	14	established	establish	VERB
aiua-13762	37	15	and	and	CCONJ
aiua-13762	37	16	potential	potential	ADJ
aiua-13762	37	17	prostate	prostate	NOUN
aiua-13762	37	18	cancer	cancer	NOUN
aiua-13762	37	19	predisposition	predisposition	NOUN
aiua-13762	37	20	genes	gene	NOUN
aiua-13762	37	21	in	in	ADP
aiua-13762	37	22	aj	aj	PROPN
aiua-13762	37	23	,	,	PUNCT
aiua-13762	37	24	with	with	ADP
aiua-13762	37	25	the	the	DET
aiua-13762	37	26	goal	goal	NOUN
aiua-13762	37	27	of	of	ADP
aiua-13762	37	28	clarifying	clarify	VERB
aiua-13762	37	29	the	the	DET
aiua-13762	37	30	genetic	genetic	ADJ
aiua-13762	37	31	underpinnings	underpinning	NOUN
aiua-13762	37	32	and	and	CCONJ
aiua-13762	37	33	implications	implication	NOUN
aiua-13762	37	34	for	for	ADP
aiua-13762	37	35	risk	risk	NOUN
aiua-13762	37	36	stratification	stratification	NOUN
aiua-13762	37	37	in	in	ADP
aiua-13762	37	38	this	this	DET
aiua-13762	37	39	unique	unique	ADJ
aiua-13762	37	40	population	population	NOUN
aiua-13762	37	41	.	.	PUNCT
aiua-13762	38	1	methods	method	NOUN
aiua-13762	38	2	inclusion	inclusion	NOUN
aiua-13762	38	3	criteria	criterion	NOUN
aiua-13762	38	4	for	for	ADP
aiua-13762	38	5	literature	literature	NOUN
aiua-13762	38	6	search	search	NOUN
aiua-13762	38	7	we	we	PRON
aiua-13762	38	8	included	include	VERB
aiua-13762	38	9	full	full	ADJ
aiua-13762	38	10	-	-	PUNCT
aiua-13762	38	11	text	text	NOUN
aiua-13762	38	12	articles	article	NOUN
aiua-13762	38	13	published	publish	VERB
aiua-13762	38	14	in	in	ADP
aiua-13762	38	15	english	english	PROPN
aiua-13762	38	16	that	that	PRON
aiua-13762	38	17	reported	report	VERB
aiua-13762	38	18	studies	study	NOUN
aiua-13762	38	19	evaluating	evaluate	VERB
aiua-13762	38	20	the	the	DET
aiua-13762	38	21	prevalence	prevalence	NOUN
aiua-13762	38	22	of	of	ADP
aiua-13762	38	23	dna	dna	PROPN
aiua-13762	38	24	mutations	mutation	NOUN
aiua-13762	38	25	in	in	ADP
aiua-13762	38	26	cohorts	cohort	NOUN
aiua-13762	38	27	of	of	ADP
aiua-13762	38	28	ashkenazi	ashkenazi	ADJ
aiua-13762	38	29	jewish	jewish	ADJ
aiua-13762	38	30	patients	patient	NOUN
aiua-13762	38	31	of	of	ADP
aiua-13762	38	32	any	any	DET
aiua-13762	38	33	age	age	NOUN
aiua-13762	38	34	diagnosed	diagnose	VERB
aiua-13762	38	35	with	with	ADP
aiua-13762	38	36	prostate	prostate	NOUN
aiua-13762	38	37	cancer	cancer	NOUN
aiua-13762	38	38	,	,	PUNCT
aiua-13762	38	39	regardless	regardless	ADV
aiua-13762	38	40	of	of	ADP
aiua-13762	38	41	grade	grade	NOUN
aiua-13762	38	42	,	,	PUNCT
aiua-13762	38	43	including	include	VERB
aiua-13762	38	44	both	both	CCONJ
aiua-13762	38	45	lethal	lethal	ADJ
aiua-13762	38	46	and	and	CCONJ
aiua-13762	38	47	nonlethal	nonlethal	ADJ
aiua-13762	38	48	forms	form	NOUN
aiua-13762	38	49	.	.	PUNCT
aiua-13762	39	1	our	our	PRON
aiua-13762	39	2	selection	selection	NOUN
aiua-13762	39	3	encompassed	encompass	VERB
aiua-13762	39	4	a	a	DET
aiua-13762	39	5	variety	variety	NOUN
aiua-13762	39	6	of	of	ADP
aiua-13762	39	7	study	study	NOUN
aiua-13762	39	8	designs	design	NOUN
aiua-13762	39	9	,	,	PUNCT
aiua-13762	39	10	including	include	VERB
aiua-13762	39	11	casecontrol	casecontrol	NOUN
aiua-13762	39	12	studies	study	NOUN
aiua-13762	39	13	,	,	PUNCT
aiua-13762	39	14	single	single	ADJ
aiua-13762	39	15	-	-	PUNCT
aiua-13762	39	16	cohort	cohort	NOUN
aiua-13762	39	17	studies	study	NOUN
aiua-13762	39	18	,	,	PUNCT
aiua-13762	39	19	case	case	NOUN
aiua-13762	39	20	series	series	NOUN
aiua-13762	39	21	,	,	PUNCT
aiua-13762	39	22	systematic	systematic	ADJ
aiua-13762	39	23	reviews	review	NOUN
aiua-13762	39	24	and	and	CCONJ
aiua-13762	39	25	meta	meta	NOUN
aiua-13762	39	26	-	-	PUNCT
aiua-13762	39	27	analyses	analysis	NOUN
aiua-13762	39	28	.	.	PUNCT
aiua-13762	40	1	the	the	DET
aiua-13762	40	2	search	search	NOUN
aiua-13762	40	3	strategy	strategy	NOUN
aiua-13762	40	4	performed	perform	VERB
aiua-13762	40	5	in	in	ADP
aiua-13762	40	6	pubmed	pubmed	PROPN
aiua-13762	40	7	utilized	utilize	VERB
aiua-13762	40	8	a	a	DET
aiua-13762	40	9	combination	combination	NOUN
aiua-13762	40	10	of	of	ADP
aiua-13762	40	11	keywords	keyword	NOUN
aiua-13762	40	12	and	and	CCONJ
aiua-13762	40	13	mesh	mesh	NOUN
aiua-13762	40	14	terms	term	NOUN
aiua-13762	40	15	to	to	PART
aiua-13762	40	16	retrieve	retrieve	VERB
aiua-13762	40	17	relevant	relevant	ADJ
aiua-13762	40	18	literature	literature	NOUN
aiua-13762	40	19	.	.	PUNCT
aiua-13762	41	1	key	key	ADJ
aiua-13762	41	2	search	search	NOUN
aiua-13762	41	3	terms	term	NOUN
aiua-13762	41	4	included	include	VERB
aiua-13762	41	5	:	:	PUNCT
aiua-13762	41	6	"	"	PUNCT
aiua-13762	41	7	prostate	prostate	NOUN
aiua-13762	41	8	,	,	PUNCT
aiua-13762	41	9	"	"	PUNCT
aiua-13762	41	10	"	"	PUNCT
aiua-13762	41	11	cancer/	cancer/	NUM
aiua-13762	41	12	carcinoma	carcinoma	NOUN
aiua-13762	41	13	,	,	PUNCT
aiua-13762	41	14	"	"	PUNCT
aiua-13762	41	15	"	"	PUNCT
aiua-13762	41	16	ashkenazi	ashkenazi	ADJ
aiua-13762	41	17	,	,	PUNCT
aiua-13762	41	18	"	"	PUNCT
aiua-13762	41	19	"	"	PUNCT
aiua-13762	41	20	jew	jew	PROPN
aiua-13762	41	21	/	/	SYM
aiua-13762	41	22	jews	jews	PROPN
aiua-13762	41	23	/	/	SYM
aiua-13762	41	24	jewish	jewish	ADJ
aiua-13762	41	25	,	,	PUNCT
aiua-13762	41	26	"	"	PUNCT
aiua-13762	41	27	"	"	PUNCT
aiua-13762	41	28	mutation*/	mutation*/	X
aiua-13762	41	29	polymorphism*/deletion*/insertion	polymorphism*/deletion*/insertion	NOUN
aiua-13762	41	30	*	*	NUM
aiua-13762	41	31	”	"	PUNCT
aiua-13762	41	32	,	,	PUNCT
aiua-13762	41	33	“	"	PUNCT
aiua-13762	41	34	linkage	linkage	NOUN
aiua-13762	41	35	"	"	PUNCT
aiua-13762	41	36	and	and	CCONJ
aiua-13762	41	37	others	other	NOUN
aiua-13762	41	38	.	.	PUNCT
aiua-13762	42	1	all	all	DET
aiua-13762	42	2	searches	search	NOUN
aiua-13762	42	3	were	be	AUX
aiua-13762	42	4	confirmed	confirm	VERB
aiua-13762	42	5	to	to	PART
aiua-13762	42	6	be	be	AUX
aiua-13762	42	7	up	up	ADP
aiua-13762	42	8	to	to	ADP
aiua-13762	42	9	date	date	NOUN
aiua-13762	42	10	as	as	ADP
aiua-13762	42	11	of	of	ADP
aiua-13762	42	12	january	january	PROPN
aiua-13762	42	13	31st	31st	NOUN
aiua-13762	42	14	,	,	PUNCT
aiua-13762	42	15	2025	2025	NUM
aiua-13762	42	16	.	.	PUNCT
aiua-13762	43	1	filters	filter	NOUN
aiua-13762	43	2	were	be	AUX
aiua-13762	43	3	applied	apply	VERB
aiua-13762	43	4	to	to	PART
aiua-13762	43	5	limit	limit	VERB
aiua-13762	43	6	results	result	NOUN
aiua-13762	43	7	to	to	ADP
aiua-13762	43	8	human	human	ADJ
aiua-13762	43	9	studies	study	NOUN
aiua-13762	43	10	.	.	PUNCT
aiua-13762	44	1	additional	additional	ADJ
aiua-13762	44	2	databases	database	NOUN
aiua-13762	44	3	(	(	PUNCT
aiua-13762	44	4	e.g.	e.g.	ADV
aiua-13762	44	5	,	,	PUNCT
aiua-13762	44	6	scopus	scopus	PROPN
aiua-13762	44	7	,	,	PUNCT
aiua-13762	44	8	embase	embase	NOUN
aiua-13762	44	9	)	)	PUNCT
aiua-13762	44	10	were	be	AUX
aiua-13762	44	11	searched	search	VERB
aiua-13762	44	12	with	with	ADP
aiua-13762	44	13	similar	similar	ADJ
aiua-13762	44	14	strategies	strategy	NOUN
aiua-13762	44	15	.	.	PUNCT
aiua-13762	45	1	articles	article	NOUN
aiua-13762	45	2	written	write	VERB
aiua-13762	45	3	in	in	ADP
aiua-13762	45	4	hebrew	hebrew	PROPN
aiua-13762	45	5	were	be	AUX
aiua-13762	45	6	also	also	ADV
aiua-13762	45	7	hand	hand	NOUN
aiua-13762	45	8	-	-	PUNCT
aiua-13762	45	9	searched	search	VERB
aiua-13762	45	10	and	and	CCONJ
aiua-13762	45	11	translated	translate	VERB
aiua-13762	45	12	for	for	ADP
aiua-13762	45	13	a	a	DET
aiua-13762	45	14	total	total	NOUN
aiua-13762	45	15	of	of	ADP
aiua-13762	45	16	69	69	NUM
aiua-13762	45	17	records	record	NOUN
aiua-13762	45	18	which	which	PRON
aiua-13762	45	19	were	be	AUX
aiua-13762	45	20	retrieved	retrieve	VERB
aiua-13762	45	21	and	and	CCONJ
aiua-13762	45	22	are	be	AUX
aiua-13762	45	23	reviewed	review	VERB
aiua-13762	45	24	in	in	ADP
aiua-13762	45	25	this	this	DET
aiua-13762	45	26	article	article	NOUN
aiua-13762	45	27	.	.	PUNCT
aiua-13762	46	1	results	result	VERB
aiua-13762	46	2	studies	study	NOUN
aiua-13762	46	3	on	on	ADP
aiua-13762	46	4	genetic	genetic	ADJ
aiua-13762	46	5	loci	loci	NOUN
aiua-13762	46	6	linked	link	VERB
aiua-13762	46	7	to	to	ADP
aiua-13762	46	8	prostate	prostate	NOUN
aiua-13762	46	9	cancer	cancer	NOUN
aiua-13762	46	10	evidence	evidence	NOUN
aiua-13762	46	11	emerging	emerge	VERB
aiua-13762	46	12	from	from	ADP
aiua-13762	46	13	research	research	NOUN
aiua-13762	46	14	on	on	ADP
aiua-13762	46	15	genetic	genetic	ADJ
aiua-13762	46	16	loci	loci	NOUN
aiua-13762	46	17	linked	link	VERB
aiua-13762	46	18	to	to	ADP
aiua-13762	46	19	pca	pca	PROPN
aiua-13762	46	20	has	have	AUX
aiua-13762	46	21	provided	provide	VERB
aiua-13762	46	22	important	important	ADJ
aiua-13762	46	23	insights	insight	NOUN
aiua-13762	46	24	into	into	ADP
aiua-13762	46	25	the	the	DET
aiua-13762	46	26	molecular	molecular	ADJ
aiua-13762	46	27	underpinnings	underpinning	NOUN
aiua-13762	46	28	of	of	ADP
aiua-13762	46	29	disease	disease	NOUN
aiua-13762	46	30	susceptibility	susceptibility	NOUN
aiua-13762	46	31	.	.	PUNCT
aiua-13762	47	1	genome	genome	NOUN
aiua-13762	47	2	-	-	PUNCT
aiua-13762	47	3	wide	wide	ADJ
aiua-13762	47	4	linkage	linkage	NOUN
aiua-13762	47	5	studies	study	NOUN
aiua-13762	47	6	have	have	AUX
aiua-13762	47	7	identified	identify	VERB
aiua-13762	47	8	over	over	ADP
aiua-13762	47	9	140	140	NUM
aiua-13762	47	10	variants	variant	NOUN
aiua-13762	47	11	of	of	ADP
aiua-13762	47	12	susceptibility	susceptibility	NOUN
aiua-13762	47	13	loci	locus	NOUN
aiua-13762	47	14	that	that	PRON
aiua-13762	47	15	may	may	AUX
aiua-13762	47	16	confer	confer	VERB
aiua-13762	47	17	an	an	DET
aiua-13762	47	18	increased	increase	VERB
aiua-13762	47	19	risk	risk	NOUN
aiua-13762	47	20	of	of	ADP
aiua-13762	47	21	pca	pca	NOUN
aiua-13762	47	22	in	in	ADP
aiua-13762	47	23	certain	certain	ADJ
aiua-13762	47	24	chromosomal	chromosomal	ADJ
aiua-13762	47	25	regions	region	NOUN
aiua-13762	47	26	(	(	PUNCT
aiua-13762	47	27	21	21	NUM
aiua-13762	47	28	,	,	PUNCT
aiua-13762	47	29	22	22	NUM
aiua-13762	47	30	)	)	PUNCT
aiua-13762	47	31	.	.	PUNCT
aiua-13762	48	1	a	a	DET
aiua-13762	48	2	summary	summary	NOUN
aiua-13762	48	3	of	of	ADP
aiua-13762	48	4	the	the	DET
aiua-13762	48	5	loci	loci	NOUN
aiua-13762	48	6	investigated	investigate	VERB
aiua-13762	48	7	up	up	ADP
aiua-13762	48	8	to	to	ADP
aiua-13762	48	9	year	year	NOUN
aiua-13762	48	10	2016	2016	NUM
aiua-13762	48	11	has	have	AUX
aiua-13762	48	12	been	be	AUX
aiua-13762	48	13	published	publish	VERB
aiua-13762	48	14	by	by	ADP
aiua-13762	48	15	lynch	lynch	PROPN
aiua-13762	48	16	and	and	CCONJ
aiua-13762	48	17	colleagues	colleague	NOUN
aiua-13762	48	18	(	(	PUNCT
aiua-13762	48	19	23	23	NUM
aiua-13762	48	20	)	)	PUNCT
aiua-13762	48	21	.	.	PUNCT
aiua-13762	49	1	hpc1	hpc1	PROPN
aiua-13762	49	2	at	at	ADP
aiua-13762	49	3	1q24	1q24	NUM
aiua-13762	49	4	,	,	PUNCT
aiua-13762	49	5	pcap	pcap	NOUN
aiua-13762	49	6	at	at	ADP
aiua-13762	49	7	1q42	1q42	NUM
aiua-13762	49	8	,	,	PUNCT
aiua-13762	49	9	hpcx	hpcx	VERB
aiua-13762	49	10	at	at	ADP
aiua-13762	49	11	xq27	xq27	PROPN
aiua-13762	49	12	,	,	PUNCT
aiua-13762	49	13	capb	capb	NOUN
aiua-13762	49	14	at	at	ADP
aiua-13762	49	15	1p36	1p36	NUM
aiua-13762	49	16	,	,	PUNCT
aiua-13762	49	17	hpc20	hpc20	PROPN
aiua-13762	49	18	at	at	ADP
aiua-13762	49	19	20q13	20q13	NUM
aiua-13762	49	20	,	,	PUNCT
aiua-13762	49	21	and	and	CCONJ
aiua-13762	49	22	elac2	elac2	NOUN
aiua-13762	49	23	at	at	ADP
aiua-13762	49	24	17p11	17p11	NUM
aiua-13762	49	25	are	be	AUX
aiua-13762	49	26	among	among	ADP
aiua-13762	49	27	the	the	DET
aiua-13762	49	28	most	most	ADV
aiua-13762	49	29	investigated	investigate	VERB
aiua-13762	49	30	genetic	genetic	ADJ
aiua-13762	49	31	loci	loci	NOUN
aiua-13762	49	32	(	(	PUNCT
aiua-13762	49	33	24	24	NUM
aiua-13762	49	34	)	)	PUNCT
aiua-13762	49	35	.	.	PUNCT
aiua-13762	50	1	xu	xu	PROPN
aiua-13762	50	2	et	et	PROPN
aiua-13762	51	1	al	al	PROPN
aiua-13762	51	2	.	.	PROPN
aiua-13762	51	3	conducted	conduct	VERB
aiua-13762	51	4	linkage	linkage	NOUN
aiua-13762	51	5	studies	study	NOUN
aiua-13762	51	6	to	to	PART
aiua-13762	51	7	investigate	investigate	VERB
aiua-13762	51	8	the	the	DET
aiua-13762	51	9	genetic	genetic	ADJ
aiua-13762	51	10	factors	factor	NOUN
aiua-13762	51	11	contributing	contribute	VERB
aiua-13762	51	12	to	to	ADP
aiua-13762	51	13	prostate	prostate	NOUN
aiua-13762	51	14	cancer	cancer	NOUN
aiua-13762	51	15	susceptibility	susceptibility	NOUN
aiua-13762	51	16	in	in	ADP
aiua-13762	51	17	159	159	NUM
aiua-13762	51	18	aj	aj	PROPN
aiua-13762	51	19	families	family	NOUN
aiua-13762	51	20	with	with	ADP
aiua-13762	51	21	multiple	multiple	ADJ
aiua-13762	51	22	affected	affected	ADJ
aiua-13762	51	23	members	member	NOUN
aiua-13762	51	24	,	,	PUNCT
aiua-13762	51	25	focusing	focus	VERB
aiua-13762	51	26	on	on	ADP
aiua-13762	51	27	the	the	DET
aiua-13762	51	28	short	short	ADJ
aiua-13762	51	29	arm	arm	NOUN
aiua-13762	51	30	of	of	ADP
aiua-13762	51	31	chromosome	chromosome	NOUN
aiua-13762	51	32	8	8	NUM
aiua-13762	51	33	(	(	PUNCT
aiua-13762	51	34	25	25	NUM
aiua-13762	51	35	)	)	PUNCT
aiua-13762	51	36	.	.	PUNCT
aiua-13762	52	1	they	they	PRON
aiua-13762	52	2	identified	identify	VERB
aiua-13762	52	3	evidence	evidence	NOUN
aiua-13762	52	4	of	of	ADP
aiua-13762	52	5	linkage	linkage	NOUN
aiua-13762	52	6	with	with	ADP
aiua-13762	52	7	pca	pca	PROPN
aiua-13762	52	8	at	at	ADP
aiua-13762	52	9	the	the	DET
aiua-13762	52	10	8p22	8p22	NUM
aiua-13762	52	11	-	-	SYM
aiua-13762	52	12	23	23	NUM
aiua-13762	52	13	locus	locus	NOUN
aiua-13762	52	14	(	(	PUNCT
aiua-13762	52	15	logarithm	logarithm	NOUN
aiua-13762	52	16	of	of	ADP
aiua-13762	52	17	the	the	DET
aiua-13762	52	18	odds	odd	NOUN
aiua-13762	52	19	[	[	X
aiua-13762	52	20	lod	lod	X
aiua-13762	52	21	]	]	X
aiua-13762	52	22	=	=	SYM
aiua-13762	52	23	1.84	1.84	NUM
aiua-13762	52	24	,	,	PUNCT
aiua-13762	52	25	p	p	X
aiua-13762	52	26	=	=	NOUN
aiua-13762	52	27	0.004	0.004	NUM
aiua-13762	52	28	)	)	PUNCT
aiua-13762	52	29	,	,	PUNCT
aiua-13762	52	30	which	which	PRON
aiua-13762	52	31	includes	include	VERB
aiua-13762	52	32	genes	gene	NOUN
aiua-13762	52	33	such	such	ADJ
aiua-13762	52	34	as	as	ADP
aiua-13762	52	35	zbtb7a	zbtb7a	NUM
aiua-13762	52	36	/	/	SYM
aiua-13762	52	37	lrf	lrf	NOUN
aiua-13762	52	38	(	(	PUNCT
aiua-13762	52	39	a	a	DET
aiua-13762	52	40	transcription	transcription	NOUN
aiua-13762	52	41	factor	factor	NOUN
aiua-13762	52	42	involved	involve	VERB
aiua-13762	52	43	in	in	ADP
aiua-13762	52	44	cell	cell	NOUN
aiua-13762	52	45	proliferation	proliferation	NOUN
aiua-13762	52	46	and	and	CCONJ
aiua-13762	52	47	differentiation	differentiation	NOUN
aiua-13762	52	48	)	)	PUNCT
aiua-13762	52	49	and	and	CCONJ
aiua-13762	52	50	various	various	ADJ
aiua-13762	52	51	genes	gene	NOUN
aiua-13762	52	52	with	with	ADP
aiua-13762	52	53	putative	putative	ADJ
aiua-13762	52	54	tumor	tumor	NOUN
aiua-13762	52	55	-	-	PUNCT
aiua-13762	52	56	suppressor	suppressor	NOUN
aiua-13762	52	57	activity	activity	NOUN
aiua-13762	52	58	,	,	PUNCT
aiua-13762	52	59	like	like	ADP
aiua-13762	52	60	the	the	DET
aiua-13762	52	61	n33	n33	NUM
aiua-13762	52	62	macrophage	macrophage	ADJ
aiua-13762	52	63	-	-	PUNCT
aiua-13762	52	64	scavenger	scavenger	NOUN
aiua-13762	52	65	receptor	receptor	NOUN
aiua-13762	52	66	,	,	PUNCT
aiua-13762	52	67	the	the	DET
aiua-13762	52	68	nat1/2	nat1/2	NUM
aiua-13762	52	69	n	n	CCONJ
aiua-13762	52	70	-	-	PUNCT
aiua-13762	52	71	acetyltransferases	acetyltransferase	NOUN
aiua-13762	52	72	,	,	PUNCT
aiua-13762	52	73	lzts1	lzts1	PROPN
aiua-13762	52	74	(	(	PUNCT
aiua-13762	52	75	a	a	DET
aiua-13762	52	76	gene	gene	NOUN
aiua-13762	52	77	frequently	frequently	ADV
aiua-13762	52	78	mutated	mutate	VERB
aiua-13762	52	79	in	in	ADP
aiua-13762	52	80	prostate	prostate	NOUN
aiua-13762	52	81	cancer	cancer	NOUN
aiua-13762	52	82	cell	cell	NOUN
aiua-13762	52	83	lines	line	NOUN
aiua-13762	52	84	)	)	PUNCT
aiua-13762	52	85	,	,	PUNCT
aiua-13762	52	86	and	and	CCONJ
aiua-13762	52	87	deleted	delete	VERB
aiua-13762	52	88	in	in	ADP
aiua-13762	52	89	liver	liver	NOUN
aiua-13762	52	90	cancer-1	cancer-1	NUM
aiua-13762	52	91	(	(	PUNCT
aiua-13762	52	92	dlc1	dlc1	PROPN
aiua-13762	52	93	)	)	PUNCT
aiua-13762	52	94	.	.	PUNCT
aiua-13762	53	1	linkage	linkage	NOUN
aiua-13762	53	2	analysis	analysis	NOUN
aiua-13762	53	3	revealed	reveal	VERB
aiua-13762	53	4	that	that	SCONJ
aiua-13762	53	5	specific	specific	ADJ
aiua-13762	53	6	microsatellite	microsatellite	ADJ
aiua-13762	53	7	markers	marker	NOUN
aiua-13762	53	8	were	be	AUX
aiua-13762	53	9	associated	associate	VERB
aiua-13762	53	10	with	with	ADP
aiua-13762	53	11	prostate	prostate	NOUN
aiua-13762	53	12	cancer	cancer	NOUN
aiua-13762	53	13	across	across	ADP
aiua-13762	53	14	multiple	multiple	ADJ
aiua-13762	53	15	familial	familial	ADJ
aiua-13762	53	16	lines	line	NOUN
aiua-13762	53	17	.	.	PUNCT
aiua-13762	54	1	a	a	DET
aiua-13762	54	2	study	study	NOUN
aiua-13762	54	3	by	by	ADP
aiua-13762	54	4	alanee	alanee	PROPN
aiua-13762	54	5	and	and	CCONJ
aiua-13762	54	6	coworkers	coworker	NOUN
aiua-13762	54	7	investigated	investigate	VERB
aiua-13762	54	8	the	the	DET
aiua-13762	54	9	prevalence	prevalence	NOUN
aiua-13762	54	10	of	of	ADP
aiua-13762	54	11	the	the	DET
aiua-13762	54	12	rare	rare	ADJ
aiua-13762	54	13	missense	missense	NOUN
aiua-13762	54	14	variant	variant	NOUN
aiua-13762	54	15	g84e	g84e	NOUN
aiua-13762	54	16	in	in	ADP
aiua-13762	54	17	the	the	DET
aiua-13762	54	18	homeobox	homeobox	NOUN
aiua-13762	54	19	b13	b13	NOUN
aiua-13762	54	20	(	(	PUNCT
aiua-13762	54	21	hoxb13	hoxb13	INTJ
aiua-13762	54	22	)	)	PUNCT
aiua-13762	54	23	gene	gene	NOUN
aiua-13762	54	24	,	,	PUNCT
aiua-13762	54	25	a	a	DET
aiua-13762	54	26	known	know	VERB
aiua-13762	54	27	familial	familial	ADJ
aiua-13762	54	28	pca	pca	NOUN
aiua-13762	54	29	-	-	PUNCT
aiua-13762	54	30	predisposing	predispose	VERB
aiua-13762	54	31	gene	gene	NOUN
aiua-13762	54	32	located	locate	VERB
aiua-13762	54	33	at	at	ADP
aiua-13762	54	34	the	the	DET
aiua-13762	54	35	17q21	17q21	NUM
aiua-13762	54	36	-	-	SYM
aiua-13762	54	37	22	22	NUM
aiua-13762	54	38	region	region	NOUN
aiua-13762	54	39	(	(	PUNCT
aiua-13762	54	40	26	26	NUM
aiua-13762	54	41	)	)	PUNCT
aiua-13762	54	42	.	.	PUNCT
aiua-13762	55	1	in	in	ADP
aiua-13762	55	2	a	a	DET
aiua-13762	55	3	prior	prior	ADJ
aiua-13762	55	4	study	study	NOUN
aiua-13762	55	5	performed	perform	VERB
aiua-13762	55	6	in	in	ADP
aiua-13762	55	7	the	the	DET
aiua-13762	55	8	general	general	ADJ
aiua-13762	55	9	population	population	NOUN
aiua-13762	55	10	,	,	PUNCT
aiua-13762	55	11	the	the	DET
aiua-13762	55	12	carrier	carrier	NOUN
aiua-13762	55	13	frequency	frequency	NOUN
aiua-13762	55	14	of	of	ADP
aiua-13762	55	15	the	the	DET
aiua-13762	55	16	variant	variant	NOUN
aiua-13762	55	17	was	be	AUX
aiua-13762	55	18	found	find	VERB
aiua-13762	55	19	to	to	PART
aiua-13762	55	20	be	be	AUX
aiua-13762	55	21	1.4	1.4	NUM
aiua-13762	55	22	%	%	NOUN
aiua-13762	55	23	in	in	ADP
aiua-13762	55	24	men	man	NOUN
aiua-13762	55	25	affected	affect	VERB
aiua-13762	55	26	by	by	ADP
aiua-13762	55	27	pca	pca	PROPN
aiua-13762	55	28	,	,	PUNCT
aiua-13762	55	29	compared	compare	VERB
aiua-13762	55	30	to	to	ADP
aiua-13762	55	31	0.1	0.1	NUM
aiua-13762	55	32	%	%	NOUN
aiua-13762	55	33	in	in	ADP
aiua-13762	55	34	individuals	individual	NOUN
aiua-13762	55	35	without	without	ADP
aiua-13762	55	36	the	the	DET
aiua-13762	55	37	disease	disease	NOUN
aiua-13762	55	38	(	(	PUNCT
aiua-13762	55	39	odds	odd	VERB
aiua-13762	55	40	ratio	ratio	NOUN
aiua-13762	55	41	[	[	X
aiua-13762	55	42	or	or	CCONJ
aiua-13762	55	43	]	]	PUNCT
aiua-13762	55	44	=	=	SYM
aiua-13762	55	45	20.1	20.1	NUM
aiua-13762	55	46	,	,	PUNCT
aiua-13762	55	47	95	95	NUM
aiua-13762	55	48	%	%	NOUN
aiua-13762	55	49	confidence	confidence	NOUN
aiua-13762	55	50	interval	interval	NOUN
aiua-13762	56	1	[	[	X
aiua-13762	56	2	ci	ci	X
aiua-13762	56	3	]	]	X
aiua-13762	56	4	=	=	NOUN
aiua-13762	56	5	3.5	3.5	NUM
aiua-13762	56	6	-	-	SYM
aiua-13762	56	7	803.3	803.3	NUM
aiua-13762	56	8	)	)	PUNCT
aiua-13762	56	9	(	(	PUNCT
aiua-13762	56	10	27	27	NUM
aiua-13762	56	11	)	)	PUNCT
aiua-13762	56	12	.	.	PUNCT
aiua-13762	57	1	the	the	DET
aiua-13762	57	2	alanee	alanee	PROPN
aiua-13762	57	3	study	study	NOUN
aiua-13762	57	4	included	include	VERB
aiua-13762	57	5	889	889	NUM
aiua-13762	57	6	selfreported	selfreporte	VERB
aiua-13762	57	7	aj	aj	PROPN
aiua-13762	57	8	men	man	NOUN
aiua-13762	57	9	and	and	CCONJ
aiua-13762	57	10	920	920	NUM
aiua-13762	57	11	non	non	ADJ
aiua-13762	57	12	-	-	ADJ
aiua-13762	57	13	aj	aj	ADJ
aiua-13762	57	14	men	man	NOUN
aiua-13762	57	15	.	.	PUNCT
aiua-13762	58	1	four	four	NUM
aiua-13762	58	2	patients	patient	NOUN
aiua-13762	58	3	were	be	AUX
aiua-13762	58	4	heterozygous	heterozygous	ADJ
aiua-13762	58	5	for	for	ADP
aiua-13762	58	6	the	the	DET
aiua-13762	58	7	g84e	g84e	NOUN
aiua-13762	58	8	variant	variant	NOUN
aiua-13762	58	9	,	,	PUNCT
aiua-13762	58	10	all	all	PRON
aiua-13762	58	11	of	of	ADP
aiua-13762	58	12	whom	whom	PRON
aiua-13762	58	13	were	be	AUX
aiua-13762	58	14	of	of	ADP
aiua-13762	58	15	non	non	ADJ
aiua-13762	58	16	-	-	ADJ
aiua-13762	58	17	aj	aj	ADJ
aiua-13762	58	18	descent	descent	NOUN
aiua-13762	58	19	.	.	PUNCT
aiua-13762	59	1	therefore	therefore	ADV
aiua-13762	59	2	,	,	PUNCT
aiua-13762	59	3	the	the	DET
aiua-13762	59	4	g84e	g84e	NOUN
aiua-13762	59	5	variant	variant	NOUN
aiua-13762	59	6	does	do	AUX
aiua-13762	59	7	not	not	PART
aiua-13762	59	8	appear	appear	VERB
aiua-13762	59	9	to	to	PART
aiua-13762	59	10	show	show	VERB
aiua-13762	59	11	increased	increase	VERB
aiua-13762	59	12	prevalence	prevalence	NOUN
aiua-13762	59	13	in	in	ADP
aiua-13762	59	14	aj	aj	PROPN
aiua-13762	59	15	.	.	PUNCT
aiua-13762	60	1	in	in	ADP
aiua-13762	60	2	a	a	DET
aiua-13762	60	3	genome	genome	NOUN
aiua-13762	60	4	-	-	PUNCT
aiua-13762	60	5	wide	wide	ADJ
aiua-13762	60	6	linkage	linkage	NOUN
aiua-13762	60	7	analysis	analysis	NOUN
aiua-13762	60	8	of	of	ADP
aiua-13762	60	9	ashkenazi	ashkenazi	ADJ
aiua-13762	60	10	families	family	NOUN
aiua-13762	60	11	,	,	PUNCT
aiua-13762	60	12	friedrichsen	friedrichsen	PROPN
aiua-13762	60	13	et	et	PROPN
aiua-13762	60	14	al	al	PROPN
aiua-13762	60	15	.	.	PROPN
aiua-13762	60	16	identified	identify	VERB
aiua-13762	60	17	a	a	DET
aiua-13762	60	18	prostate	prostate	NOUN
aiua-13762	60	19	cancer	cancer	NOUN
aiua-13762	60	20	susceptibility	susceptibility	NOUN
aiua-13762	60	21	locus	locus	NOUN
aiua-13762	60	22	on	on	ADP
aiua-13762	60	23	chromosome	chromosome	NOUN
aiua-13762	60	24	7q11	7q11	NUM
aiua-13762	60	25	-	-	SYM
aiua-13762	60	26	21	21	NUM
aiua-13762	60	27	,	,	PUNCT
aiua-13762	60	28	characterized	characterize	VERB
aiua-13762	60	29	by	by	ADP
aiua-13762	60	30	a	a	DET
aiua-13762	60	31	nonparametric	nonparametric	NOUN
aiua-13762	60	32	linkage	linkage	NOUN
aiua-13762	60	33	score	score	NOUN
aiua-13762	60	34	of	of	ADP
aiua-13762	60	35	3	3	NUM
aiua-13762	60	36	(	(	PUNCT
aiua-13762	60	37	lod	lod	PROPN
aiua-13762	60	38	=	=	SYM
aiua-13762	60	39	1.14	1.14	NUM
aiua-13762	60	40	;	;	PUNCT
aiua-13762	60	41	p	p	X
aiua-13762	60	42	=	=	NOUN
aiua-13762	60	43	0.0013	0.0013	NUM
aiua-13762	60	44	)	)	PUNCT
aiua-13762	60	45	(	(	PUNCT
aiua-13762	60	46	28	28	NUM
aiua-13762	60	47	)	)	PUNCT
aiua-13762	60	48	.	.	PUNCT
aiua-13762	61	1	notably	notably	ADV
aiua-13762	61	2	,	,	PUNCT
aiua-13762	61	3	they	they	PRON
aiua-13762	61	4	could	could	AUX
aiua-13762	61	5	not	not	PART
aiua-13762	61	6	replicate	replicate	VERB
aiua-13762	61	7	the	the	DET
aiua-13762	61	8	significant	significant	ADJ
aiua-13762	61	9	findings	finding	NOUN
aiua-13762	61	10	of	of	ADP
aiua-13762	61	11	xu	xu	PROPN
aiua-13762	61	12	et	et	PROPN
aiua-13762	61	13	al	al	PROPN
aiua-13762	61	14	.	.	PROPN
aiua-13762	62	1	regarding	regard	VERB
aiua-13762	62	2	the	the	DET
aiua-13762	62	3	8p22	8p22	NOUN
aiua-13762	62	4	locus	locus	NOUN
aiua-13762	62	5	,	,	PUNCT
aiua-13762	62	6	as	as	SCONJ
aiua-13762	62	7	no	no	DET
aiua-13762	62	8	significant	significant	ADJ
aiua-13762	62	9	linkage	linkage	NOUN
aiua-13762	62	10	was	be	AUX
aiua-13762	62	11	observed	observe	VERB
aiua-13762	62	12	at	at	ADP
aiua-13762	62	13	8p22	8p22	NOUN
aiua-13762	62	14	(	(	PUNCT
aiua-13762	62	15	allele	allele	NOUN
aiua-13762	62	16	sharing	share	VERB
aiua-13762	62	17	lod	lod	PROPN
aiua-13762	62	18	=	=	PROPN
aiua-13762	62	19	0.01	0.01	NUM
aiua-13762	62	20	)	)	PUNCT
aiua-13762	62	21	.	.	PUNCT
aiua-13762	63	1	in	in	ADP
aiua-13762	63	2	a	a	DET
aiua-13762	63	3	cohort	cohort	NOUN
aiua-13762	63	4	of	of	ADP
aiua-13762	63	5	963	963	NUM
aiua-13762	63	6	aj	aj	PROPN
aiua-13762	63	7	cases	case	NOUN
aiua-13762	63	8	and	and	CCONJ
aiua-13762	63	9	613	613	NUM
aiua-13762	63	10	aj	aj	PROPN
aiua-13762	63	11	controls	control	NOUN
aiua-13762	63	12	,	,	PUNCT
aiua-13762	63	13	vijai	vijai	NOUN
aiua-13762	63	14	and	and	CCONJ
aiua-13762	63	15	coworkers	coworker	NOUN
aiua-13762	63	16	genotyped	genotype	VERB
aiua-13762	63	17	29	29	NUM
aiua-13762	63	18	single	single	ADJ
aiua-13762	63	19	nucleotide	nucleotide	ADJ
aiua-13762	63	20	polymorphisms	polymorphism	NOUN
aiua-13762	63	21	archivio	archivio	NOUN
aiua-13762	63	22	italiano	italiano	X
aiua-13762	63	23	di	di	X
aiua-13762	63	24	urologia	urologia	PROPN
aiua-13762	63	25	e	e	PROPN
aiua-13762	63	26	andrologia	andrologia	NOUN
aiua-13762	63	27	2025	2025	NUM
aiua-13762	63	28	;	;	PUNCT
aiua-13762	63	29	97(2):13762	97(2):13762	NUM
aiua-13762	63	30	3	3	NUM
aiua-13762	63	31	genetic	genetic	NOUN
aiua-13762	63	32	of	of	ADP
aiua-13762	63	33	prostate	prostate	NOUN
aiua-13762	63	34	cancer	cancer	NOUN
aiua-13762	63	35	(	(	PUNCT
aiua-13762	63	36	snps	snps	PROPN
aiua-13762	63	37	)	)	PUNCT
aiua-13762	63	38	previously	previously	ADV
aiua-13762	63	39	linked	link	VERB
aiua-13762	63	40	to	to	ADP
aiua-13762	63	41	pca	pca	NOUN
aiua-13762	63	42	risk	risk	NOUN
aiua-13762	63	43	(	(	PUNCT
aiua-13762	63	44	29	29	NUM
aiua-13762	63	45	)	)	PUNCT
aiua-13762	63	46	.	.	PUNCT
aiua-13762	64	1	they	they	PRON
aiua-13762	64	2	found	find	VERB
aiua-13762	64	3	that	that	SCONJ
aiua-13762	64	4	a	a	DET
aiua-13762	64	5	number	number	NOUN
aiua-13762	64	6	of	of	ADP
aiua-13762	64	7	candidate	candidate	NOUN
aiua-13762	64	8	snps	snps	PROPN
aiua-13762	64	9	(	(	PUNCT
aiua-13762	64	10	rs7008482	rs7008482	PROPN
aiua-13762	64	11	,	,	PUNCT
aiua-13762	64	12	rs1016343	rs1016343	PROPN
aiua-13762	64	13	,	,	PUNCT
aiua-13762	64	14	rs13254738	rs13254738	PROPN
aiua-13762	64	15	,	,	PUNCT
aiua-13762	64	16	rs6983267	rs6983267	NOUN
aiua-13762	64	17	,	,	PUNCT
aiua-13762	64	18	rs7000448	rs7000448	NOUN
aiua-13762	64	19	,	,	PUNCT
aiua-13762	64	20	rs4242382	rs4242382	NOUN
aiua-13762	64	21	,	,	PUNCT
aiua-13762	64	22	rs7931342	rs7931342	PROPN
aiua-13762	64	23	,	,	PUNCT
aiua-13762	64	24	rs10896449	rs10896449	PROPN
aiua-13762	64	25	,	,	PUNCT
aiua-13762	64	26	rs4430796	rs4430796	PROPN
aiua-13762	64	27	,	,	PUNCT
aiua-13762	64	28	and	and	CCONJ
aiua-13762	64	29	rs5945572	rs5945572	PROPN
aiua-13762	64	30	)	)	PUNCT
aiua-13762	64	31	did	do	AUX
aiua-13762	64	32	not	not	PART
aiua-13762	64	33	show	show	VERB
aiua-13762	64	34	significant	significant	ADJ
aiua-13762	64	35	differences	difference	NOUN
aiua-13762	64	36	in	in	ADP
aiua-13762	64	37	frequency	frequency	NOUN
aiua-13762	64	38	compared	compare	VERB
aiua-13762	64	39	to	to	ADP
aiua-13762	64	40	prior	prior	ADJ
aiua-13762	64	41	studies	study	NOUN
aiua-13762	64	42	conducted	conduct	VERB
aiua-13762	64	43	on	on	ADP
aiua-13762	64	44	subjects	subject	NOUN
aiua-13762	64	45	of	of	ADP
aiua-13762	64	46	european	european	PROPN
aiua-13762	64	47	nonjewish	nonjewish	PROPN
aiua-13762	64	48	ancestry	ancestry	PROPN
aiua-13762	64	49	(	(	PUNCT
aiua-13762	64	50	age	age	NOUN
aiua-13762	64	51	-	-	PUNCT
aiua-13762	64	52	unadjusted	unadjuste	VERB
aiua-13762	64	53	analysis	analysis	NOUN
aiua-13762	64	54	)	)	PUNCT
aiua-13762	64	55	.	.	PUNCT
aiua-13762	65	1	it	it	PRON
aiua-13762	65	2	was	be	AUX
aiua-13762	65	3	concluded	conclude	VERB
aiua-13762	65	4	that	that	SCONJ
aiua-13762	65	5	there	there	PRON
aiua-13762	65	6	is	be	VERB
aiua-13762	65	7	no	no	DET
aiua-13762	65	8	evidence	evidence	NOUN
aiua-13762	65	9	of	of	ADP
aiua-13762	65	10	major	major	ADJ
aiua-13762	65	11	differences	difference	NOUN
aiua-13762	65	12	between	between	ADP
aiua-13762	65	13	aj	aj	PROPN
aiua-13762	65	14	individuals	individual	NOUN
aiua-13762	65	15	and	and	CCONJ
aiua-13762	65	16	non	non	ADJ
aiua-13762	65	17	-	-	ADJ
aiua-13762	65	18	jewish	jewish	ADJ
aiua-13762	65	19	europeans	european	NOUN
aiua-13762	65	20	regarding	regard	VERB
aiua-13762	65	21	the	the	DET
aiua-13762	65	22	association	association	NOUN
aiua-13762	65	23	between	between	ADP
aiua-13762	65	24	these	these	DET
aiua-13762	65	25	mutations	mutation	NOUN
aiua-13762	65	26	and	and	CCONJ
aiua-13762	65	27	pca	pca	PROPN
aiua-13762	65	28	.	.	PUNCT
aiua-13762	66	1	however	however	ADV
aiua-13762	66	2	,	,	PUNCT
aiua-13762	66	3	in	in	ADP
aiua-13762	66	4	a	a	DET
aiua-13762	66	5	separate	separate	ADJ
aiua-13762	66	6	investigation	investigation	NOUN
aiua-13762	66	7	,	,	PUNCT
aiua-13762	66	8	the	the	DET
aiua-13762	66	9	same	same	ADJ
aiua-13762	66	10	group	group	NOUN
aiua-13762	66	11	found	find	VERB
aiua-13762	66	12	that	that	SCONJ
aiua-13762	66	13	the	the	DET
aiua-13762	66	14	a	a	NOUN
aiua-13762	66	15	/	/	SYM
aiua-13762	66	16	a	a	DET
aiua-13762	66	17	genotype	genotype	NOUN
aiua-13762	66	18	of	of	ADP
aiua-13762	66	19	snp	snp	ADJ
aiua-13762	66	20	rs10486567	rs10486567	PROPN
aiua-13762	66	21	in	in	ADP
aiua-13762	66	22	the	the	DET
aiua-13762	66	23	7jazf1	7jazf1	ADJ
aiua-13762	66	24	gene	gene	NOUN
aiua-13762	66	25	(	(	PUNCT
aiua-13762	66	26	chromosome	chromosome	NOUN
aiua-13762	66	27	7	7	NUM
aiua-13762	66	28	)	)	PUNCT
aiua-13762	66	29	and	and	CCONJ
aiua-13762	66	30	the	the	DET
aiua-13762	66	31	rs7008482	rs7008482	PROPN
aiua-13762	66	32	snp	snp	PROPN
aiua-13762	66	33	(	(	PUNCT
aiua-13762	66	34	g	g	PROPN
aiua-13762	66	35	/	/	SYM
aiua-13762	66	36	g	g	NOUN
aiua-13762	66	37	)	)	PUNCT
aiua-13762	66	38	in	in	ADP
aiua-13762	66	39	the	the	DET
aiua-13762	66	40	8q24	8q24	NOUN
aiua-13762	66	41	locus	locus	NOUN
aiua-13762	66	42	were	be	AUX
aiua-13762	66	43	significantly	significantly	ADV
aiua-13762	66	44	associated	associate	VERB
aiua-13762	66	45	with	with	ADP
aiua-13762	66	46	biochemical	biochemical	ADJ
aiua-13762	66	47	recurrence	recurrence	NOUN
aiua-13762	66	48	(	(	PUNCT
aiua-13762	66	49	30	30	NUM
aiua-13762	66	50	)	)	PUNCT
aiua-13762	66	51	.	.	PUNCT
aiua-13762	67	1	additionally	additionally	ADV
aiua-13762	67	2	,	,	PUNCT
aiua-13762	67	3	the	the	DET
aiua-13762	67	4	7jazf1	7jazf1	ADJ
aiua-13762	67	5	rs10486567	rs10486567	NOUN
aiua-13762	67	6	snp	snp	NOUN
aiua-13762	67	7	(	(	PUNCT
aiua-13762	67	8	c	c	X
aiua-13762	67	9	/	/	SYM
aiua-13762	67	10	c	c	NOUN
aiua-13762	67	11	)	)	PUNCT
aiua-13762	67	12	was	be	AUX
aiua-13762	67	13	linked	link	VERB
aiua-13762	67	14	to	to	ADP
aiua-13762	67	15	castration	castration	NOUN
aiua-13762	67	16	-	-	PUNCT
aiua-13762	67	17	resistant	resistant	ADJ
aiua-13762	67	18	metastases	metastasis	NOUN
aiua-13762	67	19	.	.	PUNCT
aiua-13762	68	1	notably	notably	ADV
aiua-13762	68	2	,	,	PUNCT
aiua-13762	68	3	the	the	DET
aiua-13762	68	4	7jazf1	7jazf1	ADJ
aiua-13762	68	5	gene	gene	NOUN
aiua-13762	68	6	is	be	AUX
aiua-13762	68	7	a	a	DET
aiua-13762	68	8	transcriptional	transcriptional	ADJ
aiua-13762	68	9	repressor	repressor	NOUN
aiua-13762	68	10	of	of	ADP
aiua-13762	68	11	the	the	DET
aiua-13762	68	12	nr2c2	nr2c2	PROPN
aiua-13762	68	13	nuclear	nuclear	ADJ
aiua-13762	68	14	receptor	receptor	NOUN
aiua-13762	68	15	,	,	PUNCT
aiua-13762	68	16	which	which	PRON
aiua-13762	68	17	is	be	AUX
aiua-13762	68	18	expressed	express	VERB
aiua-13762	68	19	in	in	ADP
aiua-13762	68	20	the	the	DET
aiua-13762	68	21	prostate	prostate	NOUN
aiua-13762	68	22	and	and	CCONJ
aiua-13762	68	23	interacts	interact	VERB
aiua-13762	68	24	with	with	ADP
aiua-13762	68	25	the	the	DET
aiua-13762	68	26	androgen	androgen	NOUN
aiua-13762	68	27	receptor	receptor	NOUN
aiua-13762	68	28	.	.	PUNCT
aiua-13762	69	1	two	two	NUM
aiua-13762	69	2	additional	additional	ADJ
aiua-13762	69	3	snps	snps	NOUN
aiua-13762	69	4	,	,	PUNCT
aiua-13762	69	5	rs4962416	rs4962416	PROPN
aiua-13762	69	6	(	(	PUNCT
aiua-13762	69	7	c	c	X
aiua-13762	69	8	/	/	SYM
aiua-13762	69	9	c	c	NOUN
aiua-13762	69	10	genotype	genotype	NOUN
aiua-13762	69	11	,	,	PUNCT
aiua-13762	69	12	in	in	ADP
aiua-13762	69	13	the	the	DET
aiua-13762	69	14	10q26	10q26	NUM
aiua-13762	69	15	locus	locus	NOUN
aiua-13762	69	16	)	)	PUNCT
aiua-13762	69	17	and	and	CCONJ
aiua-13762	69	18	rs6465657	rs6465657	PROPN
aiua-13762	69	19	(	(	PUNCT
aiua-13762	69	20	c	c	X
aiua-13762	69	21	/	/	SYM
aiua-13762	69	22	c	c	NOUN
aiua-13762	69	23	genotype	genotype	NOUN
aiua-13762	69	24	,	,	PUNCT
aiua-13762	69	25	in	in	ADP
aiua-13762	69	26	the	the	DET
aiua-13762	69	27	7q21	7q21	NOUN
aiua-13762	69	28	locus	locus	NOUN
aiua-13762	69	29	)	)	PUNCT
aiua-13762	69	30	,	,	PUNCT
aiua-13762	69	31	were	be	AUX
aiua-13762	69	32	significantly	significantly	ADV
aiua-13762	69	33	associated	associate	VERB
aiua-13762	69	34	with	with	ADP
aiua-13762	69	35	metastatic	metastatic	ADJ
aiua-13762	69	36	disease	disease	NOUN
aiua-13762	69	37	,	,	PUNCT
aiua-13762	69	38	while	while	SCONJ
aiua-13762	69	39	rs2735839	rs2735839	NOUN
aiua-13762	69	40	(	(	PUNCT
aiua-13762	69	41	a	a	PRON
aiua-13762	69	42	/	/	SYM
aiua-13762	69	43	a	a	NOUN
aiua-13762	69	44	in	in	ADP
aiua-13762	69	45	the	the	DET
aiua-13762	69	46	19q13	19q13	NUM
aiua-13762	69	47	locus	locus	NOUN
aiua-13762	69	48	)	)	PUNCT
aiua-13762	69	49	was	be	AUX
aiua-13762	69	50	associated	associate	VERB
aiua-13762	69	51	with	with	ADP
aiua-13762	69	52	pca	pca	NOUN
aiua-13762	69	53	-	-	PUNCT
aiua-13762	69	54	specific	specific	ADJ
aiua-13762	69	55	mortality	mortality	NOUN
aiua-13762	69	56	.	.	PUNCT
aiua-13762	70	1	the	the	DET
aiua-13762	70	2	authors	author	NOUN
aiua-13762	70	3	suggested	suggest	VERB
aiua-13762	70	4	that	that	SCONJ
aiua-13762	70	5	their	their	PRON
aiua-13762	70	6	results	result	NOUN
aiua-13762	70	7	warrant	warrant	VERB
aiua-13762	70	8	validation	validation	NOUN
aiua-13762	70	9	in	in	ADP
aiua-13762	70	10	larger	large	ADJ
aiua-13762	70	11	cohorts	cohort	NOUN
aiua-13762	70	12	.	.	PUNCT
aiua-13762	71	1	mutations	mutation	NOUN
aiua-13762	71	2	in	in	ADP
aiua-13762	71	3	the	the	DET
aiua-13762	71	4	y	y	PROPN
aiua-13762	71	5	-	-	PUNCT
aiua-13762	71	6	chromosome	chromosome	NOUN
aiua-13762	71	7	have	have	AUX
aiua-13762	71	8	been	be	AUX
aiua-13762	71	9	linked	link	VERB
aiua-13762	71	10	to	to	ADP
aiua-13762	71	11	various	various	ADJ
aiua-13762	71	12	cardiological	cardiological	ADJ
aiua-13762	71	13	and	and	CCONJ
aiua-13762	71	14	neurological	neurological	ADJ
aiua-13762	71	15	diseases	disease	NOUN
aiua-13762	71	16	,	,	PUNCT
aiua-13762	71	17	as	as	ADV
aiua-13762	71	18	well	well	ADV
aiua-13762	71	19	as	as	ADP
aiua-13762	71	20	to	to	ADP
aiua-13762	71	21	male	male	NOUN
aiua-13762	71	22	-	-	PUNCT
aiua-13762	71	23	specific	specific	ADJ
aiua-13762	71	24	neoplasia	neoplasia	NOUN
aiua-13762	71	25	such	such	ADJ
aiua-13762	71	26	as	as	ADP
aiua-13762	71	27	pca	pca	PROPN
aiua-13762	71	28	(	(	PUNCT
aiua-13762	71	29	31	31	NUM
aiua-13762	71	30	)	)	PUNCT
aiua-13762	71	31	.	.	PUNCT
aiua-13762	72	1	loss	loss	NOUN
aiua-13762	72	2	of	of	ADP
aiua-13762	72	3	the	the	DET
aiua-13762	72	4	y	y	PROPN
aiua-13762	72	5	chromosome	chromosome	NOUN
aiua-13762	72	6	is	be	AUX
aiua-13762	72	7	frequently	frequently	ADV
aiua-13762	72	8	observed	observe	VERB
aiua-13762	72	9	in	in	ADP
aiua-13762	72	10	prostate	prostate	NOUN
aiua-13762	72	11	cancer	cancer	NOUN
aiua-13762	72	12	and	and	CCONJ
aiua-13762	72	13	may	may	AUX
aiua-13762	72	14	serve	serve	VERB
aiua-13762	72	15	as	as	ADP
aiua-13762	72	16	an	an	DET
aiua-13762	72	17	early	early	ADJ
aiua-13762	72	18	marker	marker	NOUN
aiua-13762	72	19	of	of	ADP
aiua-13762	72	20	prostate	prostate	NOUN
aiua-13762	72	21	carcinogenesis	carcinogenesis	NOUN
aiua-13762	72	22	.	.	PUNCT
aiua-13762	73	1	wang	wang	PROPN
aiua-13762	73	2	et	et	PROPN
aiua-13762	73	3	al	al	PROPN
aiua-13762	73	4	.	.	PROPN
aiua-13762	73	5	identified	identify	VERB
aiua-13762	73	6	a	a	DET
aiua-13762	73	7	significant	significant	ADJ
aiua-13762	73	8	association	association	NOUN
aiua-13762	73	9	between	between	ADP
aiua-13762	73	10	specific	specific	ADJ
aiua-13762	73	11	y	y	PROPN
aiua-13762	73	12	chromosome	chromosome	NOUN
aiua-13762	73	13	haplogroups	haplogroup	NOUN
aiua-13762	73	14	and	and	CCONJ
aiua-13762	73	15	pca	pca	NOUN
aiua-13762	73	16	susceptibility	susceptibility	NOUN
aiua-13762	73	17	(	(	PUNCT
aiua-13762	73	18	32	32	NUM
aiua-13762	73	19	)	)	PUNCT
aiua-13762	73	20	.	.	PUNCT
aiua-13762	74	1	in	in	ADP
aiua-13762	74	2	particular	particular	ADJ
aiua-13762	74	3	,	,	PUNCT
aiua-13762	74	4	the	the	DET
aiua-13762	74	5	e1b1b1c	e1b1b1c	PROPN
aiua-13762	74	6	haplogroup	haplogroup	NOUN
aiua-13762	74	7	(	(	PUNCT
aiua-13762	74	8	located	locate	VERB
aiua-13762	74	9	in	in	ADP
aiua-13762	74	10	the	the	DET
aiua-13762	74	11	last	last	ADJ
aiua-13762	74	12	intron	intron	NOUN
aiua-13762	74	13	of	of	ADP
aiua-13762	74	14	the	the	DET
aiua-13762	74	15	taxilin	taxilin	NOUN
aiua-13762	74	16	gamma	gamma	NOUN
aiua-13762	74	17	2	2	NUM
aiua-13762	74	18	pseudogene	pseudogene	NOUN
aiua-13762	74	19	in	in	ADP
aiua-13762	74	20	the	the	DET
aiua-13762	74	21	yq11.222	yq11.222	NOUN
aiua-13762	74	22	locus	locus	NOUN
aiua-13762	74	23	)	)	PUNCT
aiua-13762	74	24	was	be	AUX
aiua-13762	74	25	significant	significant	ADJ
aiua-13762	74	26	in	in	ADP
aiua-13762	74	27	overall	overall	ADJ
aiua-13762	74	28	pca	pca	NOUN
aiua-13762	74	29	groups	group	NOUN
aiua-13762	74	30	,	,	PUNCT
aiua-13762	74	31	with	with	ADP
aiua-13762	74	32	some	some	DET
aiua-13762	74	33	evidence	evidence	NOUN
aiua-13762	74	34	suggesting	suggest	VERB
aiua-13762	74	35	a	a	DET
aiua-13762	74	36	protective	protective	ADJ
aiua-13762	74	37	effect	effect	NOUN
aiua-13762	74	38	.	.	PUNCT
aiua-13762	75	1	interestingly	interestingly	ADV
aiua-13762	75	2	,	,	PUNCT
aiua-13762	75	3	this	this	DET
aiua-13762	75	4	haplogroup	haplogroup	NOUN
aiua-13762	75	5	is	be	AUX
aiua-13762	75	6	found	find	VERB
aiua-13762	75	7	at	at	ADP
aiua-13762	75	8	a	a	DET
aiua-13762	75	9	higher	high	ADJ
aiua-13762	75	10	frequency	frequency	NOUN
aiua-13762	75	11	in	in	ADP
aiua-13762	75	12	aj	aj	PROPN
aiua-13762	75	13	(	(	PUNCT
aiua-13762	75	14	10	10	NUM
aiua-13762	75	15	-	-	SYM
aiua-13762	75	16	11	11	NUM
aiua-13762	75	17	%	%	NOUN
aiua-13762	75	18	)	)	PUNCT
aiua-13762	75	19	compared	compare	VERB
aiua-13762	75	20	to	to	ADP
aiua-13762	75	21	men	man	NOUN
aiua-13762	75	22	of	of	ADP
aiua-13762	75	23	european	european	ADJ
aiua-13762	75	24	,	,	PUNCT
aiua-13762	75	25	non	non	ADJ
aiua-13762	75	26	-	-	ADJ
aiua-13762	75	27	jewish	jewish	ADJ
aiua-13762	75	28	ancestry	ancestry	NOUN
aiua-13762	75	29	(	(	PUNCT
aiua-13762	75	30	1	1	NUM
aiua-13762	75	31	-	-	SYM
aiua-13762	75	32	2	2	NUM
aiua-13762	75	33	%	%	NOUN
aiua-13762	75	34	)	)	PUNCT
aiua-13762	75	35	.	.	PUNCT
aiua-13762	76	1	however	however	ADV
aiua-13762	76	2	,	,	PUNCT
aiua-13762	76	3	the	the	DET
aiua-13762	76	4	authors	author	NOUN
aiua-13762	76	5	cautioned	caution	VERB
aiua-13762	76	6	that	that	SCONJ
aiua-13762	76	7	the	the	DET
aiua-13762	76	8	statistical	statistical	ADJ
aiua-13762	76	9	power	power	NOUN
aiua-13762	76	10	of	of	ADP
aiua-13762	76	11	some	some	DET
aiua-13762	76	12	analyses	analysis	NOUN
aiua-13762	76	13	was	be	AUX
aiua-13762	76	14	insufficient	insufficient	ADJ
aiua-13762	76	15	,	,	PUNCT
aiua-13762	76	16	and	and	CCONJ
aiua-13762	76	17	thus	thus	ADV
aiua-13762	76	18	refrained	refrain	VERB
aiua-13762	76	19	from	from	ADP
aiua-13762	76	20	making	make	VERB
aiua-13762	76	21	definitive	definitive	ADJ
aiua-13762	76	22	conclusions	conclusion	NOUN
aiua-13762	76	23	.	.	PUNCT
aiua-13762	77	1	in	in	ADP
aiua-13762	77	2	jewish	jewish	ADJ
aiua-13762	77	3	populations	population	NOUN
aiua-13762	77	4	of	of	ADP
aiua-13762	77	5	non	non	ADJ
aiua-13762	77	6	-	-	ADJ
aiua-13762	77	7	ashkenazi	ashkenazi	ADJ
aiua-13762	77	8	ancestry	ancestry	NOUN
aiua-13762	77	9	,	,	PUNCT
aiua-13762	77	10	a	a	DET
aiua-13762	77	11	study	study	NOUN
aiua-13762	77	12	by	by	ADP
aiua-13762	77	13	álvarez	álvarez	NOUN
aiua-13762	77	14	-	-	PUNCT
aiua-13762	77	15	topete	topete	NOUN
aiua-13762	77	16	et	et	PROPN
aiua-13762	77	17	al	al	PROPN
aiua-13762	77	18	.	.	PROPN
aiua-13762	77	19	examined	examine	VERB
aiua-13762	77	20	y	y	ADJ
aiua-13762	77	21	-	-	ADJ
aiua-13762	77	22	chromosomal	chromosomal	ADJ
aiua-13762	77	23	haplogroups	haplogroup	NOUN
aiua-13762	77	24	prevalent	prevalent	ADJ
aiua-13762	77	25	in	in	ADP
aiua-13762	77	26	a	a	DET
aiua-13762	77	27	cohort	cohort	NOUN
aiua-13762	77	28	of	of	ADP
aiua-13762	77	29	mexican	mexican	ADJ
aiua-13762	77	30	pca	pca	PROPN
aiua-13762	77	31	patients	patient	NOUN
aiua-13762	77	32	.	.	PUNCT
aiua-13762	78	1	their	their	PRON
aiua-13762	78	2	findings	finding	NOUN
aiua-13762	78	3	revealed	reveal	VERB
aiua-13762	78	4	a	a	DET
aiua-13762	78	5	significant	significant	ADJ
aiua-13762	78	6	association	association	NOUN
aiua-13762	78	7	between	between	ADP
aiua-13762	78	8	haplogroups	haplogroup	NOUN
aiua-13762	78	9	such	such	ADJ
aiua-13762	78	10	as	as	ADP
aiua-13762	78	11	r1a	r1a	PROPN
aiua-13762	78	12	(	(	PUNCT
aiua-13762	78	13	age	age	NOUN
aiua-13762	78	14	-	-	PUNCT
aiua-13762	78	15	adjusted	adjust	VERB
aiua-13762	78	16	or	or	CCONJ
aiua-13762	78	17	,	,	PUNCT
aiua-13762	78	18	7.4	7.4	NUM
aiua-13762	78	19	,	,	PUNCT
aiua-13762	78	20	95	95	NUM
aiua-13762	78	21	%	%	NOUN
aiua-13762	78	22	ci	ci	NOUN
aiua-13762	78	23	,	,	PUNCT
aiua-13762	78	24	1.3	1.3	NUM
aiua-13762	78	25	-	-	SYM
aiua-13762	78	26	42.1	42.1	NUM
aiua-13762	78	27	)	)	PUNCT
aiua-13762	78	28	and	and	CCONJ
aiua-13762	78	29	increased	increase	VERB
aiua-13762	78	30	susceptibility	susceptibility	NOUN
aiua-13762	78	31	to	to	ADP
aiua-13762	78	32	pca	pca	PROPN
aiua-13762	78	33	.	.	PUNCT
aiua-13762	79	1	the	the	DET
aiua-13762	79	2	authors	author	NOUN
aiua-13762	79	3	hypothesize	hypothesize	VERB
aiua-13762	79	4	that	that	SCONJ
aiua-13762	79	5	these	these	DET
aiua-13762	79	6	lineages	lineage	NOUN
aiua-13762	79	7	may	may	AUX
aiua-13762	79	8	reflect	reflect	VERB
aiua-13762	79	9	a	a	DET
aiua-13762	79	10	founder	founder	NOUN
aiua-13762	79	11	effect	effect	NOUN
aiua-13762	79	12	associated	associate	VERB
aiua-13762	79	13	with	with	ADP
aiua-13762	79	14	converso	converso	ADJ
aiua-13762	79	15	heritage	heritage	NOUN
aiua-13762	79	16	,	,	PUNCT
aiua-13762	79	17	specifically	specifically	ADV
aiua-13762	79	18	sephardic	sephardic	ADJ
aiua-13762	79	19	jews	jews	PROPN
aiua-13762	79	20	who	who	PRON
aiua-13762	79	21	converted	convert	VERB
aiua-13762	79	22	to	to	ADP
aiua-13762	79	23	christianity	christianity	NOUN
aiua-13762	79	24	during	during	ADP
aiua-13762	79	25	the	the	DET
aiua-13762	79	26	spanish	spanish	ADJ
aiua-13762	79	27	inquisition	inquisition	NOUN
aiua-13762	79	28	(	(	PUNCT
aiua-13762	79	29	33	33	NUM
aiua-13762	79	30	)	)	PUNCT
aiua-13762	79	31	.	.	PUNCT
aiua-13762	80	1	interestingly	interestingly	ADV
aiua-13762	80	2	,	,	PUNCT
aiua-13762	80	3	the	the	DET
aiua-13762	80	4	r1a	r1a	NOUN
aiua-13762	80	5	haplogroup	haplogroup	NOUN
aiua-13762	80	6	is	be	AUX
aiua-13762	80	7	also	also	ADV
aiua-13762	80	8	found	find	VERB
aiua-13762	80	9	frequently	frequently	ADV
aiua-13762	80	10	in	in	ADP
aiua-13762	80	11	aj	aj	PROPN
aiua-13762	80	12	(	(	PUNCT
aiua-13762	80	13	34	34	NUM
aiua-13762	80	14	)	)	PUNCT
aiua-13762	80	15	,	,	PUNCT
aiua-13762	80	16	suggesting	suggest	VERB
aiua-13762	80	17	that	that	SCONJ
aiua-13762	80	18	historical	historical	ADJ
aiua-13762	80	19	intermixing	intermixing	NOUN
aiua-13762	80	20	of	of	ADP
aiua-13762	80	21	jewish	jewish	ADJ
aiua-13762	80	22	populations	population	NOUN
aiua-13762	80	23	may	may	AUX
aiua-13762	80	24	have	have	AUX
aiua-13762	80	25	contributed	contribute	VERB
aiua-13762	80	26	to	to	ADP
aiua-13762	80	27	the	the	DET
aiua-13762	80	28	persistence	persistence	NOUN
aiua-13762	80	29	of	of	ADP
aiua-13762	80	30	certain	certain	ADJ
aiua-13762	80	31	y	y	ADJ
aiua-13762	80	32	-	-	ADJ
aiua-13762	80	33	chromosomal	chromosomal	ADJ
aiua-13762	80	34	lineages	lineage	NOUN
aiua-13762	80	35	predisposing	predispose	VERB
aiua-13762	80	36	individuals	individual	NOUN
aiua-13762	80	37	to	to	ADP
aiua-13762	80	38	pca	pca	PROPN
aiua-13762	80	39	.	.	PUNCT
aiua-13762	81	1	this	this	PRON
aiua-13762	81	2	raises	raise	VERB
aiua-13762	81	3	the	the	DET
aiua-13762	81	4	question	question	NOUN
aiua-13762	81	5	of	of	ADP
aiua-13762	81	6	whether	whether	SCONJ
aiua-13762	81	7	the	the	DET
aiua-13762	81	8	association	association	NOUN
aiua-13762	81	9	reflects	reflect	VERB
aiua-13762	81	10	sephardic	sephardic	ADJ
aiua-13762	81	11	ancestry	ancestry	NOUN
aiua-13762	81	12	or	or	CCONJ
aiua-13762	81	13	the	the	DET
aiua-13762	81	14	presence	presence	NOUN
aiua-13762	81	15	of	of	ADP
aiua-13762	81	16	aj	aj	PROPN
aiua-13762	81	17	in	in	ADP
aiua-13762	81	18	spain	spain	PROPN
aiua-13762	81	19	.	.	PUNCT
aiua-13762	82	1	a	a	DET
aiua-13762	82	2	more	more	ADV
aiua-13762	82	3	radical	radical	ADJ
aiua-13762	82	4	hypothesis	hypothesis	NOUN
aiua-13762	82	5	could	could	AUX
aiua-13762	82	6	suggest	suggest	VERB
aiua-13762	82	7	that	that	SCONJ
aiua-13762	82	8	the	the	DET
aiua-13762	82	9	mutation	mutation	NOUN
aiua-13762	82	10	predates	predate	VERB
aiua-13762	82	11	the	the	DET
aiua-13762	82	12	sephardic	sephardic	ADJ
aiua-13762	82	13	-	-	PUNCT
aiua-13762	82	14	ashkenazi	ashkenazi	ADJ
aiua-13762	82	15	division	division	NOUN
aiua-13762	82	16	;	;	PUNCT
aiua-13762	82	17	however	however	ADV
aiua-13762	82	18	,	,	PUNCT
aiua-13762	82	19	this	this	DET
aiua-13762	82	20	theory	theory	NOUN
aiua-13762	82	21	would	would	AUX
aiua-13762	82	22	likely	likely	ADV
aiua-13762	82	23	predict	predict	VERB
aiua-13762	82	24	higher	high	ADJ
aiua-13762	82	25	rates	rate	NOUN
aiua-13762	82	26	of	of	ADP
aiua-13762	82	27	pca	pca	PROPN
aiua-13762	82	28	in	in	ADP
aiua-13762	82	29	contemporary	contemporary	ADJ
aiua-13762	82	30	sephardic	sephardic	ADJ
aiua-13762	82	31	populations	population	NOUN
aiua-13762	82	32	,	,	PUNCT
aiua-13762	82	33	which	which	PRON
aiua-13762	82	34	is	be	AUX
aiua-13762	82	35	not	not	PART
aiua-13762	82	36	observed	observe	VERB
aiua-13762	82	37	.	.	PUNCT
aiua-13762	83	1	therefore	therefore	ADV
aiua-13762	83	2	,	,	PUNCT
aiua-13762	83	3	the	the	DET
aiua-13762	83	4	hypothesis	hypothesis	NOUN
aiua-13762	83	5	of	of	ADP
aiua-13762	83	6	an	an	DET
aiua-13762	83	7	external	external	ADJ
aiua-13762	83	8	genetic	genetic	ADJ
aiua-13762	83	9	introduction	introduction	NOUN
aiua-13762	83	10	appears	appear	VERB
aiua-13762	83	11	more	more	ADV
aiua-13762	83	12	plausible	plausible	ADJ
aiua-13762	83	13	.	.	PUNCT
aiua-13762	84	1	germline	germline	NOUN
aiua-13762	84	2	variants	variant	NOUN
aiua-13762	84	3	in	in	ADP
aiua-13762	84	4	hpc1	hpc1	PROPN
aiua-13762	84	5	and	and	CCONJ
aiua-13762	84	6	hpcx	hpcx	VERB
aiua-13762	84	7	loci	loci	NOUN
aiua-13762	84	8	approximately	approximately	ADV
aiua-13762	84	9	25	25	NUM
aiua-13762	84	10	years	year	NOUN
aiua-13762	84	11	ago	ago	ADV
aiua-13762	84	12	,	,	PUNCT
aiua-13762	84	13	susceptibility	susceptibility	NOUN
aiua-13762	84	14	loci	locus	NOUN
aiua-13762	84	15	for	for	ADP
aiua-13762	84	16	hereditary	hereditary	ADJ
aiua-13762	84	17	prostate	prostate	NOUN
aiua-13762	84	18	cancer	cancer	NOUN
aiua-13762	84	19	(	(	PUNCT
aiua-13762	84	20	hpc	hpc	NOUN
aiua-13762	84	21	)	)	PUNCT
aiua-13762	84	22	were	be	AUX
aiua-13762	84	23	identified	identify	VERB
aiua-13762	84	24	at	at	ADP
aiua-13762	84	25	1q24	1q24	NUM
aiua-13762	84	26	-	-	SYM
aiua-13762	84	27	31	31	NUM
aiua-13762	84	28	(	(	PUNCT
aiua-13762	84	29	hpc1	hpc1	PROPN
aiua-13762	84	30	)	)	PUNCT
aiua-13762	84	31	and	and	CCONJ
aiua-13762	84	32	at	at	ADP
aiua-13762	84	33	xq27	xq27	PROPN
aiua-13762	84	34	-	-	PUNCT
aiua-13762	84	35	28	28	PROPN
aiua-13762	84	36	(	(	PUNCT
aiua-13762	84	37	hpcx	hpcx	PROPN
aiua-13762	84	38	)	)	PUNCT
aiua-13762	84	39	through	through	ADP
aiua-13762	84	40	linkage	linkage	NOUN
aiua-13762	84	41	analysis	analysis	NOUN
aiua-13762	84	42	of	of	ADP
aiua-13762	84	43	families	family	NOUN
aiua-13762	84	44	with	with	ADP
aiua-13762	84	45	a	a	DET
aiua-13762	84	46	high	high	ADJ
aiua-13762	84	47	prevalence	prevalence	NOUN
aiua-13762	84	48	of	of	ADP
aiua-13762	84	49	pca	pca	PROPN
aiua-13762	84	50	(	(	PUNCT
aiua-13762	84	51	35	35	NUM
aiua-13762	84	52	-	-	SYM
aiua-13762	84	53	37	37	NUM
aiua-13762	84	54	)	)	PUNCT
aiua-13762	84	55	.	.	PUNCT
aiua-13762	85	1	within	within	ADP
aiua-13762	85	2	the	the	DET
aiua-13762	85	3	hpc1	hpc1	PROPN
aiua-13762	85	4	region	region	NOUN
aiua-13762	85	5	,	,	PUNCT
aiua-13762	85	6	the	the	DET
aiua-13762	85	7	rnasel	rnasel	NOUN
aiua-13762	85	8	gene	gene	NOUN
aiua-13762	85	9	(	(	PUNCT
aiua-13762	85	10	1q25	1q25	NUM
aiua-13762	85	11	)	)	PUNCT
aiua-13762	85	12	,	,	PUNCT
aiua-13762	85	13	which	which	PRON
aiua-13762	85	14	encodes	encode	VERB
aiua-13762	85	15	the	the	DET
aiua-13762	85	16	2’5’-oligoadenylate	2’5’-oligoadenylate	NUM
aiua-13762	85	17	-	-	PUNCT
aiua-13762	85	18	dependent	dependent	ADJ
aiua-13762	85	19	ribonuclease	ribonuclease	NOUN
aiua-13762	85	20	l	l	NOUN
aiua-13762	85	21	,	,	PUNCT
aiua-13762	85	22	a	a	DET
aiua-13762	85	23	protein	protein	NOUN
aiua-13762	85	24	involved	involve	VERB
aiua-13762	85	25	in	in	ADP
aiua-13762	85	26	the	the	DET
aiua-13762	85	27	interferon	interferon	NOUN
aiua-13762	85	28	-	-	PUNCT
aiua-13762	85	29	regulated	regulate	VERB
aiua-13762	85	30	2	2	NUM
aiua-13762	85	31	-	-	SYM
aiua-13762	85	32	5a	5a	NUM
aiua-13762	85	33	pro	pro	ADJ
aiua-13762	85	34	-	-	ADJ
aiua-13762	85	35	apoptotic	apoptotic	ADJ
aiua-13762	85	36	pathway	pathway	NOUN
aiua-13762	85	37	,	,	PUNCT
aiua-13762	85	38	was	be	AUX
aiua-13762	85	39	identified	identify	VERB
aiua-13762	85	40	as	as	ADP
aiua-13762	85	41	a	a	DET
aiua-13762	85	42	candidate	candidate	NOUN
aiua-13762	85	43	for	for	ADP
aiua-13762	85	44	hereditary	hereditary	ADJ
aiua-13762	85	45	pca	pca	NOUN
aiua-13762	85	46	due	due	ADP
aiua-13762	85	47	to	to	ADP
aiua-13762	85	48	its	its	PRON
aiua-13762	85	49	tumor	tumor	NOUN
aiua-13762	85	50	suppressor	suppressor	NOUN
aiua-13762	85	51	activity	activity	NOUN
aiua-13762	85	52	(	(	PUNCT
aiua-13762	85	53	38	38	NUM
aiua-13762	85	54	)	)	PUNCT
aiua-13762	85	55	.	.	PUNCT
aiua-13762	86	1	in	in	ADP
aiua-13762	86	2	a	a	DET
aiua-13762	86	3	japanese	japanese	ADJ
aiua-13762	86	4	case	case	NOUN
aiua-13762	86	5	-	-	PUNCT
aiua-13762	86	6	control	control	NOUN
aiua-13762	86	7	study	study	NOUN
aiua-13762	86	8	,	,	PUNCT
aiua-13762	86	9	the	the	DET
aiua-13762	86	10	asp	asp	PROPN
aiua-13762	86	11	/	/	SYM
aiua-13762	86	12	asp	asp	PROPN
aiua-13762	86	13	phenotype	phenotype	NOUN
aiua-13762	86	14	of	of	ADP
aiua-13762	86	15	the	the	DET
aiua-13762	86	16	asp541glu	asp541glu	ADJ
aiua-13762	86	17	rnasel	rnasel	NOUN
aiua-13762	86	18	variant	variant	NOUN
aiua-13762	86	19	was	be	AUX
aiua-13762	86	20	associated	associate	VERB
aiua-13762	86	21	with	with	ADP
aiua-13762	86	22	a	a	DET
aiua-13762	86	23	6.9	6.9	NUM
aiua-13762	86	24	-	-	ADJ
aiua-13762	86	25	fold	fold	ADJ
aiua-13762	86	26	increased	increase	VERB
aiua-13762	86	27	odds	odd	NOUN
aiua-13762	86	28	of	of	ADP
aiua-13762	86	29	pca	pca	NOUN
aiua-13762	86	30	compared	compare	VERB
aiua-13762	86	31	to	to	ADP
aiua-13762	86	32	controls	control	NOUN
aiua-13762	86	33	(	(	PUNCT
aiua-13762	86	34	95	95	NUM
aiua-13762	86	35	%	%	NOUN
aiua-13762	86	36	ci	ci	NOUN
aiua-13762	86	37	,	,	PUNCT
aiua-13762	86	38	3.9	3.9	NUM
aiua-13762	86	39	-	-	SYM
aiua-13762	86	40	12.1	12.1	NUM
aiua-13762	86	41	)	)	PUNCT
aiua-13762	86	42	.	.	PUNCT
aiua-13762	87	1	in	in	ADP
aiua-13762	87	2	contrast	contrast	NOUN
aiua-13762	87	3	,	,	PUNCT
aiua-13762	87	4	the	the	DET
aiua-13762	87	5	gln	gln	PROPN
aiua-13762	87	6	/	/	SYM
aiua-13762	87	7	gln	gln	NOUN
aiua-13762	87	8	phenotype	phenotype	NOUN
aiua-13762	87	9	of	of	ADP
aiua-13762	87	10	the	the	DET
aiua-13762	87	11	arg462gln	arg462gln	ADJ
aiua-13762	87	12	variant	variant	NOUN
aiua-13762	87	13	appeared	appear	VERB
aiua-13762	87	14	to	to	PART
aiua-13762	87	15	offer	offer	VERB
aiua-13762	87	16	protection	protection	NOUN
aiua-13762	87	17	against	against	ADP
aiua-13762	87	18	pca	pca	PROPN
aiua-13762	87	19	(	(	PUNCT
aiua-13762	87	20	or	or	CCONJ
aiua-13762	87	21	,	,	PUNCT
aiua-13762	87	22	0.06	0.06	NUM
aiua-13762	87	23	,	,	PUNCT
aiua-13762	87	24	95	95	NUM
aiua-13762	87	25	%	%	NOUN
aiua-13762	87	26	ci	ci	NOUN
aiua-13762	87	27	,	,	PUNCT
aiua-13762	87	28	0.035	0.035	NUM
aiua-13762	87	29	-	-	SYM
aiua-13762	87	30	0.11	0.11	NUM
aiua-13762	87	31	)	)	PUNCT
aiua-13762	87	32	(	(	PUNCT
aiua-13762	87	33	39	39	NUM
aiua-13762	87	34	)	)	PUNCT
aiua-13762	87	35	.	.	PUNCT
aiua-13762	88	1	additionally	additionally	ADV
aiua-13762	88	2	,	,	PUNCT
aiua-13762	88	3	the	the	DET
aiua-13762	88	4	a	a	NOUN
aiua-13762	88	5	/	/	SYM
aiua-13762	88	6	a	a	DET
aiua-13762	88	7	genotype	genotype	NOUN
aiua-13762	88	8	of	of	ADP
aiua-13762	88	9	the	the	DET
aiua-13762	88	10	rs12757998	rs12757998	PROPN
aiua-13762	88	11	snp	snp	NOUN
aiua-13762	88	12	of	of	ADP
aiua-13762	88	13	rnasel	rnasel	NOUN
aiua-13762	88	14	was	be	AUX
aiua-13762	88	15	linked	link	VERB
aiua-13762	88	16	to	to	ADP
aiua-13762	88	17	a	a	DET
aiua-13762	88	18	1.63	1.63	NUM
aiua-13762	88	19	odds	odd	NOUN
aiua-13762	88	20	ratio	ratio	NOUN
aiua-13762	88	21	for	for	ADP
aiua-13762	88	22	pca	pca	NOUN
aiua-13762	88	23	compared	compare	VERB
aiua-13762	88	24	to	to	ADP
aiua-13762	88	25	controls	control	NOUN
aiua-13762	88	26	(	(	PUNCT
aiua-13762	88	27	95	95	NUM
aiua-13762	88	28	%	%	NOUN
aiua-13762	88	29	ci	ci	NOUN
aiua-13762	88	30	,	,	PUNCT
aiua-13762	88	31	1.18	1.18	NUM
aiua-13762	88	32	-	-	SYM
aiua-13762	88	33	2.25	2.25	NUM
aiua-13762	88	34	)	)	PUNCT
aiua-13762	88	35	,	,	PUNCT
aiua-13762	88	36	and	and	CCONJ
aiua-13762	88	37	a	a	DET
aiua-13762	88	38	1.9	1.9	NUM
aiua-13762	88	39	odds	odd	NOUN
aiua-13762	88	40	ratio	ratio	NOUN
aiua-13762	88	41	for	for	ADP
aiua-13762	88	42	high	high	ADJ
aiua-13762	88	43	-	-	PUNCT
aiua-13762	88	44	grade	grade	NOUN
aiua-13762	88	45	disease	disease	NOUN
aiua-13762	88	46	in	in	ADP
aiua-13762	88	47	individuals	individual	NOUN
aiua-13762	88	48	of	of	ADP
aiua-13762	88	49	northern	northern	ADJ
aiua-13762	88	50	/	/	SYM
aiua-13762	88	51	western	western	ADJ
aiua-13762	88	52	european	european	PROPN
aiua-13762	88	53	ancestry	ancestry	PROPN
aiua-13762	88	54	(	(	PUNCT
aiua-13762	88	55	gleason	gleason	PROPN
aiua-13762	88	56	>	>	X
aiua-13762	88	57	7	7	NUM
aiua-13762	88	58	,	,	PUNCT
aiua-13762	88	59	95	95	NUM
aiua-13762	88	60	%	%	NOUN
aiua-13762	88	61	ci	ci	NOUN
aiua-13762	88	62	,	,	PUNCT
aiua-13762	88	63	1.252.89	1.252.89	NUM
aiua-13762	88	64	)	)	PUNCT
aiua-13762	88	65	(	(	PUNCT
aiua-13762	88	66	40	40	NUM
aiua-13762	88	67	)	)	PUNCT
aiua-13762	88	68	.	.	PUNCT
aiua-13762	89	1	in	in	ADP
aiua-13762	89	2	addition	addition	NOUN
aiua-13762	89	3	,	,	PUNCT
aiua-13762	89	4	a	a	DET
aiua-13762	89	5	glu265x	glu265x	NOUN
aiua-13762	89	6	truncating	truncate	VERB
aiua-13762	89	7	variant	variant	NOUN
aiua-13762	89	8	of	of	ADP
aiua-13762	89	9	rnasel	rnasel	NOUN
aiua-13762	89	10	was	be	AUX
aiua-13762	89	11	found	find	VERB
aiua-13762	89	12	to	to	PART
aiua-13762	89	13	be	be	AUX
aiua-13762	89	14	expressed	express	VERB
aiua-13762	89	15	in	in	ADP
aiua-13762	89	16	pca	pca	NOUN
aiua-13762	89	17	patients	patient	NOUN
aiua-13762	89	18	from	from	ADP
aiua-13762	89	19	finland	finland	PROPN
aiua-13762	89	20	(	(	PUNCT
aiua-13762	89	21	or	or	CCONJ
aiua-13762	89	22	,	,	PUNCT
aiua-13762	89	23	4.56	4.56	NUM
aiua-13762	89	24	;	;	PUNCT
aiua-13762	89	25	p	p	X
aiua-13762	89	26	=	=	NOUN
aiua-13762	89	27	0.04	0.04	NUM
aiua-13762	89	28	)	)	PUNCT
aiua-13762	89	29	(	(	PUNCT
aiua-13762	89	30	41	41	NUM
aiua-13762	89	31	)	)	PUNCT
aiua-13762	89	32	.	.	PUNCT
aiua-13762	90	1	a	a	DET
aiua-13762	90	2	potentially	potentially	ADV
aiua-13762	90	3	pathogenic	pathogenic	ADJ
aiua-13762	90	4	rnasel	rnasel	NOUN
aiua-13762	90	5	splice	splice	NOUN
aiua-13762	90	6	site	site	NOUN
aiua-13762	90	7	mutation	mutation	NOUN
aiua-13762	90	8	(	(	PUNCT
aiua-13762	90	9	ivs5	ivs5	PROPN
aiua-13762	90	10	+	+	NOUN
aiua-13762	90	11	1delg	1delg	NUM
aiua-13762	90	12	)	)	PUNCT
aiua-13762	90	13	was	be	AUX
aiua-13762	90	14	identified	identify	VERB
aiua-13762	90	15	in	in	ADP
aiua-13762	90	16	a	a	DET
aiua-13762	90	17	study	study	NOUN
aiua-13762	90	18	performed	perform	VERB
aiua-13762	90	19	on	on	ADP
aiua-13762	90	20	ashkenazi	ashkenazi	ADJ
aiua-13762	90	21	jewish	jewish	ADJ
aiua-13762	90	22	individuals	individual	NOUN
aiua-13762	90	23	by	by	ADP
aiua-13762	90	24	orr	orr	NOUN
aiua-13762	90	25	-	-	PUNCT
aiua-13762	90	26	urteger	urteger	NOUN
aiua-13762	90	27	et	et	PROPN
aiua-13762	90	28	al	al	PROPN
aiua-13762	90	29	.	.	PUNCT
aiua-13762	91	1	(	(	PUNCT
aiua-13762	91	2	42	42	NUM
aiua-13762	91	3	)	)	PUNCT
aiua-13762	91	4	.	.	PUNCT
aiua-13762	92	1	additionally	additionally	ADV
aiua-13762	92	2	,	,	PUNCT
aiua-13762	92	3	a	a	DET
aiua-13762	92	4	novel	novel	ADJ
aiua-13762	92	5	ashkenazi	ashkenazi	ADJ
aiua-13762	92	6	founder	founder	NOUN
aiua-13762	92	7	mutation	mutation	NOUN
aiua-13762	92	8	was	be	AUX
aiua-13762	92	9	reported	report	VERB
aiua-13762	92	10	by	by	ADP
aiua-13762	92	11	rennert	rennert	NOUN
aiua-13762	92	12	and	and	CCONJ
aiua-13762	92	13	colleagues	colleague	NOUN
aiua-13762	92	14	in	in	ADP
aiua-13762	92	15	two	two	NUM
aiua-13762	92	16	siblings	sibling	NOUN
aiua-13762	92	17	affected	affect	VERB
aiua-13762	92	18	by	by	ADP
aiua-13762	92	19	pca	pca	PROPN
aiua-13762	92	20	,	,	PUNCT
aiua-13762	92	21	where	where	SCONJ
aiua-13762	92	22	loss	loss	NOUN
aiua-13762	92	23	of	of	ADP
aiua-13762	92	24	heterozygosity	heterozygosity	NOUN
aiua-13762	92	25	(	(	PUNCT
aiua-13762	92	26	loh	loh	PROPN
aiua-13762	92	27	)	)	PUNCT
aiua-13762	92	28	of	of	ADP
aiua-13762	92	29	the	the	DET
aiua-13762	92	30	wildtype	wildtype	NOUN
aiua-13762	92	31	allele	allele	PROPN
aiua-13762	92	32	occurred	occur	VERB
aiua-13762	92	33	in	in	ADP
aiua-13762	92	34	the	the	DET
aiua-13762	92	35	cancer	cancer	NOUN
aiua-13762	92	36	cells	cell	NOUN
aiua-13762	92	37	.	.	PUNCT
aiua-13762	93	1	this	this	DET
aiua-13762	93	2	mutation	mutation	NOUN
aiua-13762	93	3	consists	consist	VERB
aiua-13762	93	4	of	of	ADP
aiua-13762	93	5	a	a	DET
aiua-13762	93	6	four	four	NUM
aiua-13762	93	7	-	-	PUNCT
aiua-13762	93	8	base	base	NOUN
aiua-13762	93	9	deletion	deletion	NOUN
aiua-13762	93	10	at	at	ADP
aiua-13762	93	11	nucleotide	nucleotide	NOUN
aiua-13762	93	12	471	471	NUM
aiua-13762	93	13	in	in	ADP
aiua-13762	93	14	exon	exon	NOUN
aiua-13762	93	15	1	1	NUM
aiua-13762	93	16	(	(	PUNCT
aiua-13762	93	17	471delaaag	471delaaag	PROPN
aiua-13762	93	18	)	)	PUNCT
aiua-13762	93	19	,	,	PUNCT
aiua-13762	93	20	resulting	result	VERB
aiua-13762	93	21	in	in	ADP
aiua-13762	93	22	premature	premature	ADJ
aiua-13762	93	23	truncation	truncation	NOUN
aiua-13762	93	24	at	at	ADP
aiua-13762	93	25	codon	codon	NOUN
aiua-13762	93	26	164	164	NUM
aiua-13762	93	27	(	(	PUNCT
aiua-13762	93	28	43	43	NUM
aiua-13762	93	29	)	)	PUNCT
aiua-13762	93	30	.	.	PUNCT
aiua-13762	94	1	the	the	DET
aiua-13762	94	2	authors	author	NOUN
aiua-13762	94	3	observed	observe	VERB
aiua-13762	94	4	an	an	DET
aiua-13762	94	5	increased	increase	VERB
aiua-13762	94	6	,	,	PUNCT
aiua-13762	94	7	though	though	SCONJ
aiua-13762	94	8	not	not	PART
aiua-13762	94	9	statistically	statistically	ADV
aiua-13762	94	10	significant	significant	ADJ
aiua-13762	94	11	,	,	PUNCT
aiua-13762	94	12	frequency	frequency	NOUN
aiua-13762	94	13	of	of	ADP
aiua-13762	94	14	this	this	DET
aiua-13762	94	15	deletion	deletion	NOUN
aiua-13762	94	16	in	in	ADP
aiua-13762	94	17	pca	pca	NOUN
aiua-13762	94	18	patients	patient	NOUN
aiua-13762	94	19	of	of	ADP
aiua-13762	94	20	aj	aj	PROPN
aiua-13762	94	21	descent	descent	PROPN
aiua-13762	94	22	,	,	PUNCT
aiua-13762	94	23	compared	compare	VERB
aiua-13762	94	24	to	to	ADP
aiua-13762	94	25	aj	aj	PROPN
aiua-13762	94	26	controls	controls	PROPN
aiua-13762	94	27	(	(	PUNCT
aiua-13762	94	28	or	or	CCONJ
aiua-13762	94	29	,	,	PUNCT
aiua-13762	94	30	3	3	NUM
aiua-13762	94	31	;	;	PUNCT
aiua-13762	94	32	95	95	NUM
aiua-13762	94	33	%	%	NOUN
aiua-13762	94	34	ci	ci	NOUN
aiua-13762	94	35	,	,	PUNCT
aiua-13762	94	36	0.6	0.6	NUM
aiua-13762	94	37	-	-	SYM
aiua-13762	94	38	15.3	15.3	NUM
aiua-13762	94	39	)	)	PUNCT
aiua-13762	94	40	.	.	PUNCT
aiua-13762	95	1	notably	notably	ADV
aiua-13762	95	2	,	,	PUNCT
aiua-13762	95	3	among	among	ADP
aiua-13762	95	4	ashkenazim	ashkenazim	NOUN
aiua-13762	95	5	mutation	mutation	NOUN
aiua-13762	95	6	carriers	carrier	NOUN
aiua-13762	95	7	were	be	AUX
aiua-13762	95	8	diagnosed	diagnose	VERB
aiua-13762	95	9	at	at	ADP
aiua-13762	95	10	a	a	DET
aiua-13762	95	11	significantly	significantly	ADV
aiua-13762	95	12	younger	young	ADJ
aiua-13762	95	13	age	age	NOUN
aiua-13762	95	14	compared	compare	VERB
aiua-13762	95	15	to	to	ADP
aiua-13762	95	16	non	non	NOUN
aiua-13762	95	17	-	-	NOUN
aiua-13762	95	18	carriers	carrier	NOUN
aiua-13762	95	19	(	(	PUNCT
aiua-13762	95	20	65	65	NUM
aiua-13762	95	21	vs.	vs.	ADP
aiua-13762	95	22	74.4	74.4	NUM
aiua-13762	95	23	years	year	NOUN
aiua-13762	95	24	,	,	PUNCT
aiua-13762	95	25	respectively	respectively	ADV
aiua-13762	95	26	;	;	PUNCT
aiua-13762	95	27	p	p	X
aiua-13762	95	28	<	<	X
aiua-13762	95	29	0.001	0.001	NUM
aiua-13762	95	30	)	)	PUNCT
aiua-13762	95	31	.	.	PUNCT
aiua-13762	96	1	subsequent	subsequent	ADJ
aiua-13762	96	2	studies	study	NOUN
aiua-13762	96	3	produced	produce	VERB
aiua-13762	96	4	inconclusive	inconclusive	ADJ
aiua-13762	96	5	results	result	NOUN
aiua-13762	96	6	.	.	PUNCT
aiua-13762	97	1	a	a	DET
aiua-13762	97	2	single	single	ADJ
aiua-13762	97	3	carrier	carrier	NOUN
aiua-13762	97	4	of	of	ADP
aiua-13762	97	5	the	the	DET
aiua-13762	97	6	471delaaag	471delaaag	PROPN
aiua-13762	97	7	mutation	mutation	NOUN
aiua-13762	97	8	was	be	AUX
aiua-13762	97	9	identified	identify	VERB
aiua-13762	97	10	among	among	ADP
aiua-13762	97	11	122	122	NUM
aiua-13762	97	12	aj	aj	PROPN
aiua-13762	97	13	pca	pca	PROPN
aiua-13762	97	14	patients	patient	NOUN
aiua-13762	97	15	in	in	ADP
aiua-13762	97	16	canada	canada	PROPN
aiua-13762	97	17	(	(	PUNCT
aiua-13762	97	18	44	44	NUM
aiua-13762	97	19	)	)	PUNCT
aiua-13762	97	20	.	.	PUNCT
aiua-13762	98	1	similarly	similarly	ADV
aiua-13762	98	2	,	,	PUNCT
aiua-13762	98	3	one	one	NUM
aiua-13762	98	4	deletion	deletion	NOUN
aiua-13762	98	5	carrier	carrier	NOUN
aiua-13762	98	6	was	be	AUX
aiua-13762	98	7	found	find	VERB
aiua-13762	98	8	among	among	ADP
aiua-13762	98	9	190	190	NUM
aiua-13762	98	10	ashkenazi	ashkenazi	ADJ
aiua-13762	98	11	pca	pca	NOUN
aiua-13762	98	12	patients	patient	NOUN
aiua-13762	98	13	in	in	ADP
aiua-13762	98	14	israel	israel	PROPN
aiua-13762	98	15	,	,	PUNCT
aiua-13762	98	16	with	with	ADP
aiua-13762	98	17	no	no	DET
aiua-13762	98	18	carriers	carrier	NOUN
aiua-13762	98	19	identified	identify	VERB
aiua-13762	98	20	among	among	ADP
aiua-13762	98	21	nonashkenazi	nonashkenazi	PROPN
aiua-13762	98	22	patients	patient	NOUN
aiua-13762	98	23	(	(	PUNCT
aiua-13762	98	24	45	45	NUM
aiua-13762	98	25	)	)	PUNCT
aiua-13762	98	26	.	.	PUNCT
aiua-13762	99	1	in	in	ADP
aiua-13762	99	2	a	a	DET
aiua-13762	99	3	large	large	ADJ
aiua-13762	99	4	aj	aj	PROPN
aiua-13762	99	5	population	population	NOUN
aiua-13762	99	6	study	study	NOUN
aiua-13762	99	7	(	(	PUNCT
aiua-13762	99	8	979	979	NUM
aiua-13762	99	9	pca	pca	NOUN
aiua-13762	99	10	cases	case	NOUN
aiua-13762	99	11	and	and	CCONJ
aiua-13762	99	12	1250	1250	NUM
aiua-13762	99	13	controls	control	NOUN
aiua-13762	99	14	)	)	PUNCT
aiua-13762	99	15	,	,	PUNCT
aiua-13762	99	16	agalliu	agalliu	ADJ
aiua-13762	99	17	and	and	CCONJ
aiua-13762	99	18	colleagues	colleague	NOUN
aiua-13762	99	19	could	could	AUX
aiua-13762	99	20	not	not	PART
aiua-13762	99	21	confirm	confirm	VERB
aiua-13762	99	22	a	a	DET
aiua-13762	99	23	significant	significant	ADJ
aiua-13762	99	24	effect	effect	NOUN
aiua-13762	99	25	of	of	ADP
aiua-13762	99	26	the	the	DET
aiua-13762	99	27	471delaaag	471delaaag	PROPN
aiua-13762	99	28	mutation	mutation	NOUN
aiua-13762	99	29	on	on	ADP
aiua-13762	99	30	pca	pca	PROPN
aiua-13762	99	31	risk	risk	NOUN
aiua-13762	99	32	,	,	PUNCT
aiua-13762	99	33	citing	cite	VERB
aiua-13762	99	34	insufficient	insufficient	ADJ
aiua-13762	99	35	power	power	NOUN
aiua-13762	99	36	to	to	PART
aiua-13762	99	37	detect	detect	VERB
aiua-13762	99	38	modest	modest	ADJ
aiua-13762	99	39	associations	association	NOUN
aiua-13762	99	40	.	.	PUNCT
aiua-13762	100	1	in	in	ADP
aiua-13762	100	2	contrast	contrast	NOUN
aiua-13762	100	3	to	to	ADP
aiua-13762	100	4	the	the	DET
aiua-13762	100	5	earlier	early	ADJ
aiua-13762	100	6	japanese	japanese	ADJ
aiua-13762	100	7	study	study	NOUN
aiua-13762	100	8	,	,	PUNCT
aiua-13762	100	9	this	this	DET
aiua-13762	100	10	research	research	NOUN
aiua-13762	100	11	identified	identify	VERB
aiua-13762	100	12	an	an	DET
aiua-13762	100	13	inverse	inverse	NOUN
aiua-13762	100	14	association	association	NOUN
aiua-13762	100	15	between	between	ADP
aiua-13762	100	16	the	the	DET
aiua-13762	100	17	a	a	PROPN
aiua-13762	100	18	/	/	SYM
aiua-13762	100	19	a	a	DET
aiua-13762	100	20	genotype	genotype	NOUN
aiua-13762	100	21	(	(	PUNCT
aiua-13762	100	22	rs486907	rs486907	PROPN
aiua-13762	100	23	)	)	PUNCT
aiua-13762	100	24	of	of	ADP
aiua-13762	100	25	the	the	DET
aiua-13762	100	26	arg462gln	arg462gln	ADJ
aiua-13762	100	27	variant	variant	NOUN
aiua-13762	100	28	and	and	CCONJ
aiua-13762	100	29	pca	pca	NOUN
aiua-13762	100	30	in	in	ADP
aiua-13762	100	31	patients	patient	NOUN
aiua-13762	100	32	diagnosed	diagnose	VERB
aiua-13762	100	33	before	before	ADP
aiua-13762	100	34	age	age	NOUN
aiua-13762	100	35	65	65	NUM
aiua-13762	100	36	(	(	PUNCT
aiua-13762	100	37	or	or	CCONJ
aiua-13762	100	38	,	,	PUNCT
aiua-13762	100	39	0.47	0.47	NUM
aiua-13762	100	40	;	;	PUNCT
aiua-13762	100	41	95	95	NUM
aiua-13762	100	42	%	%	NOUN
aiua-13762	100	43	ci	ci	NOUN
aiua-13762	100	44	,	,	PUNCT
aiua-13762	100	45	0.23	0.23	NUM
aiua-13762	100	46	-	-	SYM
aiua-13762	100	47	0.96	0.96	NUM
aiua-13762	100	48	)	)	PUNCT
aiua-13762	100	49	(	(	PUNCT
aiua-13762	100	50	46	46	NUM
aiua-13762	100	51	)	)	PUNCT
aiua-13762	100	52	.	.	PUNCT
aiua-13762	101	1	furthermore	furthermore	ADV
aiua-13762	101	2	,	,	PUNCT
aiua-13762	101	3	the	the	DET
aiua-13762	101	4	study	study	NOUN
aiua-13762	101	5	examined	examine	VERB
aiua-13762	101	6	five	five	NUM
aiua-13762	101	7	microsatellite	microsatellite	ADJ
aiua-13762	101	8	markers	marker	NOUN
aiua-13762	101	9	on	on	ADP
aiua-13762	101	10	the	the	DET
aiua-13762	101	11	hpcx	hpcx	ADJ
aiua-13762	101	12	locus	locus	NOUN
aiua-13762	101	13	and	and	CCONJ
aiua-13762	101	14	found	find	VERB
aiua-13762	101	15	positive	positive	ADJ
aiua-13762	101	16	associations	association	NOUN
aiua-13762	101	17	with	with	ADP
aiua-13762	101	18	low	low	ADJ
aiua-13762	101	19	-	-	PUNCT
aiua-13762	101	20	grade	grade	NOUN
aiua-13762	101	21	pca	pca	NOUN
aiua-13762	101	22	(	(	PUNCT
aiua-13762	101	23	gleason	gleason	PROPN
aiua-13762	101	24	score	score	VERB
aiua-13762	101	25	≤	≤	NUM
aiua-13762	101	26	6	6	NUM
aiua-13762	101	27	)	)	PUNCT
aiua-13762	101	28	for	for	ADP
aiua-13762	101	29	allele	allele	NOUN
aiua-13762	101	30	archivio	archivio	PROPN
aiua-13762	101	31	italiano	italiano	X
aiua-13762	101	32	di	di	X
aiua-13762	101	33	urologia	urologia	PROPN
aiua-13762	101	34	e	e	PROPN
aiua-13762	101	35	andrologia	andrologia	NOUN
aiua-13762	101	36	2025	2025	NUM
aiua-13762	101	37	;	;	PUNCT
aiua-13762	101	38	97(2):13762	97(2):13762	NUM
aiua-13762	101	39	g.	g.	PROPN
aiua-13762	101	40	perletti	perletti	PROPN
aiua-13762	101	41	,	,	PUNCT
aiua-13762	101	42	d.	d.	PROPN
aiua-13762	101	43	cohen	cohen	PROPN
aiua-13762	101	44	hattab	hattab	PROPN
aiua-13762	101	45	,	,	PUNCT
aiua-13762	101	46	s.	s.	PROPN
aiua-13762	101	47	dellapergola	dellapergola	PROPN
aiua-13762	101	48	,	,	PUNCT
aiua-13762	101	49	et	et	PROPN
aiua-13762	101	50	al	al	PROPN
aiua-13762	101	51	.	.	PROPN
aiua-13762	101	52	4	4	NUM
aiua-13762	101	53	135	135	NUM
aiua-13762	101	54	of	of	ADP
aiua-13762	101	55	microsatellite	microsatellite	NOUN
aiua-13762	101	56	str	str	X
aiua-13762	101	57	b97	b97	NOUN
aiua-13762	101	58	and	and	CCONJ
aiua-13762	101	59	allele	allele	NOUN
aiua-13762	101	60	188	188	NUM
aiua-13762	101	61	of	of	ADP
aiua-13762	101	62	the	the	DET
aiua-13762	101	63	str	str	NOUN
aiua-13762	101	64	marker	marker	NOUN
aiua-13762	101	65	dxs1205	dxs1205	NOUN
aiua-13762	101	66	(	(	PUNCT
aiua-13762	101	67	or	or	CCONJ
aiua-13762	101	68	,	,	PUNCT
aiua-13762	101	69	1.77	1.77	NUM
aiua-13762	101	70	;	;	PUNCT
aiua-13762	101	71	95	95	NUM
aiua-13762	101	72	%	%	NOUN
aiua-13762	101	73	ci	ci	NOUN
aiua-13762	101	74	,	,	PUNCT
aiua-13762	101	75	1.15	1.15	NUM
aiua-13762	101	76	-	-	SYM
aiua-13762	101	77	2.71	2.71	NUM
aiua-13762	101	78	and	and	CCONJ
aiua-13762	101	79	or	or	CCONJ
aiua-13762	101	80	,	,	PUNCT
aiua-13762	101	81	1.65	1.65	NUM
aiua-13762	101	82	;	;	PUNCT
aiua-13762	101	83	95	95	NUM
aiua-13762	101	84	%	%	NOUN
aiua-13762	101	85	ci	ci	NOUN
aiua-13762	101	86	,	,	PUNCT
aiua-13762	101	87	1.08	1.08	NUM
aiua-13762	101	88	-	-	SYM
aiua-13762	101	89	2.54	2.54	NUM
aiua-13762	101	90	,	,	PUNCT
aiua-13762	101	91	respectively	respectively	ADV
aiua-13762	101	92	)	)	PUNCT
aiua-13762	101	93	.	.	PUNCT
aiua-13762	102	1	however	however	ADV
aiua-13762	102	2	,	,	PUNCT
aiua-13762	102	3	no	no	DET
aiua-13762	102	4	significant	significant	ADJ
aiua-13762	102	5	associations	association	NOUN
aiua-13762	102	6	were	be	AUX
aiua-13762	102	7	observed	observe	VERB
aiua-13762	102	8	for	for	ADP
aiua-13762	102	9	high	high	ADJ
aiua-13762	102	10	-	-	PUNCT
aiua-13762	102	11	grade	grade	NOUN
aiua-13762	102	12	pca	pca	NOUN
aiua-13762	102	13	.	.	PUNCT
aiua-13762	103	1	in	in	ADP
aiua-13762	103	2	conclusion	conclusion	NOUN
aiua-13762	103	3	,	,	PUNCT
aiua-13762	103	4	additional	additional	ADJ
aiua-13762	103	5	evidence	evidence	NOUN
aiua-13762	103	6	is	be	AUX
aiua-13762	103	7	awaited	await	VERB
aiua-13762	103	8	before	before	ADP
aiua-13762	103	9	drawing	draw	VERB
aiua-13762	103	10	a	a	DET
aiua-13762	103	11	conclusive	conclusive	ADJ
aiua-13762	103	12	statement	statement	NOUN
aiua-13762	103	13	about	about	ADP
aiua-13762	103	14	pca	pca	NOUN
aiua-13762	103	15	risk	risk	NOUN
aiua-13762	103	16	conferred	confer	VERB
aiua-13762	103	17	by	by	ADP
aiua-13762	103	18	471delaaag	471delaaag	PROPN
aiua-13762	103	19	in	in	ADP
aiua-13762	103	20	rnasel	rnasel	NOUN
aiua-13762	103	21	.	.	PUNCT
aiua-13762	104	1	germline	germline	NOUN
aiua-13762	104	2	variants	variant	NOUN
aiua-13762	104	3	in	in	ADP
aiua-13762	104	4	brca1	brca1	PROPN
aiua-13762	104	5	and	and	CCONJ
aiua-13762	104	6	brca2	brca2	NOUN
aiua-13762	104	7	genes	gene	VERB
aiua-13762	104	8	the	the	DET
aiua-13762	104	9	brca1	brca1	NOUN
aiua-13762	104	10	(	(	PUNCT
aiua-13762	104	11	chromosome	chromosome	NOUN
aiua-13762	104	12	17	17	NUM
aiua-13762	104	13	,	,	PUNCT
aiua-13762	104	14	17q21.31	17q21.31	NUM
aiua-13762	104	15	)	)	PUNCT
aiua-13762	104	16	and	and	CCONJ
aiua-13762	104	17	brca2	brca2	PROPN
aiua-13762	104	18	(	(	PUNCT
aiua-13762	104	19	chromosome	chromosome	NOUN
aiua-13762	104	20	13	13	NUM
aiua-13762	104	21	,	,	PUNCT
aiua-13762	104	22	13q13.1	13q13.1	NUM
aiua-13762	104	23	)	)	PUNCT
aiua-13762	104	24	gene	gene	NOUN
aiua-13762	104	25	products	product	NOUN
aiua-13762	104	26	play	play	VERB
aiua-13762	104	27	a	a	DET
aiua-13762	104	28	critical	critical	ADJ
aiua-13762	104	29	role	role	NOUN
aiua-13762	104	30	in	in	ADP
aiua-13762	104	31	dna	dna	PROPN
aiua-13762	104	32	damage	damage	NOUN
aiua-13762	104	33	detection	detection	NOUN
aiua-13762	104	34	,	,	PUNCT
aiua-13762	104	35	checkpoint	checkpoint	NOUN
aiua-13762	104	36	arrest	arrest	NOUN
aiua-13762	104	37	,	,	PUNCT
aiua-13762	104	38	doublestrand	doublestrand	VERB
aiua-13762	104	39	break	break	NOUN
aiua-13762	104	40	repair	repair	NOUN
aiua-13762	104	41	,	,	PUNCT
aiua-13762	104	42	and	and	CCONJ
aiua-13762	105	1	chromatin	chromatin	NOUN
aiua-13762	105	2	remodeling	remodeling	NOUN
aiua-13762	105	3	(	(	PUNCT
aiua-13762	105	4	47	47	NUM
aiua-13762	105	5	)	)	PUNCT
aiua-13762	105	6	.	.	PUNCT
aiua-13762	106	1	additionally	additionally	ADV
aiua-13762	106	2	,	,	PUNCT
aiua-13762	106	3	brca1	brca1	PROPN
aiua-13762	106	4	regulates	regulate	VERB
aiua-13762	106	5	the	the	DET
aiua-13762	106	6	androgen	androgen	NOUN
aiua-13762	106	7	receptor	receptor	NOUN
aiua-13762	106	8	and	and	CCONJ
aiua-13762	106	9	may	may	AUX
aiua-13762	106	10	be	be	AUX
aiua-13762	106	11	implicated	implicate	VERB
aiua-13762	106	12	in	in	ADP
aiua-13762	106	13	the	the	DET
aiua-13762	106	14	pathogenic	pathogenic	ADJ
aiua-13762	106	15	mechanisms	mechanism	NOUN
aiua-13762	106	16	of	of	ADP
aiua-13762	106	17	pca	pca	NOUN
aiua-13762	106	18	associated	associate	VERB
aiua-13762	106	19	with	with	ADP
aiua-13762	106	20	it	it	PRON
aiua-13762	106	21	(	(	PUNCT
aiua-13762	106	22	48	48	NUM
aiua-13762	106	23	)	)	PUNCT
aiua-13762	106	24	.	.	PUNCT
aiua-13762	107	1	germline	germline	NOUN
aiua-13762	107	2	mutations	mutation	NOUN
aiua-13762	107	3	in	in	ADP
aiua-13762	107	4	these	these	DET
aiua-13762	107	5	genes	gene	NOUN
aiua-13762	107	6	are	be	AUX
aiua-13762	107	7	responsible	responsible	ADJ
aiua-13762	107	8	for	for	ADP
aiua-13762	107	9	the	the	DET
aiua-13762	107	10	majority	majority	NOUN
aiua-13762	107	11	of	of	ADP
aiua-13762	107	12	hereditary	hereditary	ADJ
aiua-13762	107	13	breast	breast	NOUN
aiua-13762	107	14	and	and	CCONJ
aiua-13762	107	15	ovarian	ovarian	ADJ
aiua-13762	107	16	cancers	cancer	NOUN
aiua-13762	107	17	.	.	PUNCT
aiua-13762	108	1	these	these	DET
aiua-13762	108	2	mutations	mutation	NOUN
aiua-13762	108	3	typically	typically	ADV
aiua-13762	108	4	consist	consist	VERB
aiua-13762	108	5	of	of	ADP
aiua-13762	108	6	small	small	ADJ
aiua-13762	108	7	deletions	deletion	NOUN
aiua-13762	108	8	or	or	CCONJ
aiua-13762	108	9	insertions	insertion	NOUN
aiua-13762	108	10	and	and	CCONJ
aiua-13762	108	11	are	be	AUX
aiua-13762	108	12	inherited	inherit	VERB
aiua-13762	108	13	in	in	ADP
aiua-13762	108	14	an	an	DET
aiua-13762	108	15	autosomal	autosomal	ADJ
aiua-13762	108	16	dominant	dominant	ADJ
aiua-13762	108	17	fashion	fashion	NOUN
aiua-13762	108	18	with	with	ADP
aiua-13762	108	19	incomplete	incomplete	ADJ
aiua-13762	108	20	penetrance	penetrance	NOUN
aiua-13762	108	21	.	.	PUNCT
aiua-13762	109	1	interestingly	interestingly	ADV
aiua-13762	109	2	,	,	PUNCT
aiua-13762	109	3	in	in	ADP
aiua-13762	109	4	certain	certain	ADJ
aiua-13762	109	5	brca	brca	PROPN
aiua-13762	109	6	family	family	NOUN
aiua-13762	109	7	clusters	cluster	NOUN
aiua-13762	109	8	,	,	PUNCT
aiua-13762	109	9	the	the	DET
aiua-13762	109	10	inheritance	inheritance	NOUN
aiua-13762	109	11	pattern	pattern	NOUN
aiua-13762	109	12	of	of	ADP
aiua-13762	109	13	pca	pca	NOUN
aiua-13762	109	14	also	also	ADV
aiua-13762	109	15	resembles	resemble	VERB
aiua-13762	109	16	autosomal	autosomal	ADJ
aiua-13762	109	17	dominant	dominant	ADJ
aiua-13762	109	18	inheritance	inheritance	NOUN
aiua-13762	109	19	.	.	PUNCT
aiua-13762	110	1	for	for	ADP
aiua-13762	110	2	example	example	NOUN
aiua-13762	110	3	,	,	PUNCT
aiua-13762	110	4	in	in	ADP
aiua-13762	110	5	a	a	DET
aiua-13762	110	6	swedish	swedish	ADJ
aiua-13762	110	7	family	family	NOUN
aiua-13762	110	8	carrying	carry	VERB
aiua-13762	110	9	the	the	DET
aiua-13762	110	10	brca2	brca2	NOUN
aiua-13762	111	1	6051dela	6051dela	ADJ
aiua-13762	111	2	truncating	truncate	VERB
aiua-13762	111	3	mutation	mutation	NOUN
aiua-13762	111	4	,	,	PUNCT
aiua-13762	111	5	a	a	DET
aiua-13762	111	6	father	father	NOUN
aiua-13762	111	7	and	and	CCONJ
aiua-13762	111	8	his	his	PRON
aiua-13762	111	9	four	four	NUM
aiua-13762	111	10	sons	son	NOUN
aiua-13762	111	11	were	be	AUX
aiua-13762	111	12	diagnosed	diagnose	VERB
aiua-13762	111	13	with	with	ADP
aiua-13762	111	14	early	early	ADJ
aiua-13762	111	15	-	-	PUNCT
aiua-13762	111	16	onset	onset	NOUN
aiua-13762	111	17	pca	pca	NOUN
aiua-13762	111	18	,	,	PUNCT
aiua-13762	111	19	while	while	SCONJ
aiua-13762	111	20	three	three	NUM
aiua-13762	111	21	daughters	daughter	NOUN
aiua-13762	111	22	developed	develop	VERB
aiua-13762	111	23	breast	breast	NOUN
aiua-13762	111	24	cancer	cancer	NOUN
aiua-13762	111	25	(	(	PUNCT
aiua-13762	111	26	49	49	NUM
aiua-13762	111	27	)	)	PUNCT
aiua-13762	111	28	.	.	PUNCT
aiua-13762	112	1	in	in	ADP
aiua-13762	112	2	the	the	DET
aiua-13762	112	3	nonjewish	nonjewish	ADJ
aiua-13762	112	4	population	population	NOUN
aiua-13762	112	5	,	,	PUNCT
aiua-13762	112	6	it	it	PRON
aiua-13762	112	7	has	have	AUX
aiua-13762	112	8	been	be	AUX
aiua-13762	112	9	demonstrated	demonstrate	VERB
aiua-13762	112	10	that	that	SCONJ
aiua-13762	112	11	men	man	NOUN
aiua-13762	112	12	with	with	ADP
aiua-13762	112	13	a	a	DET
aiua-13762	112	14	brca1	brca1	NOUN
aiua-13762	112	15	mutation	mutation	NOUN
aiua-13762	112	16	have	have	VERB
aiua-13762	112	17	a	a	DET
aiua-13762	112	18	lifetime	lifetime	NOUN
aiua-13762	112	19	7	7	NUM
aiua-13762	112	20	-	-	SYM
aiua-13762	112	21	26	26	NUM
aiua-13762	112	22	%	%	NOUN
aiua-13762	112	23	risk	risk	NOUN
aiua-13762	112	24	of	of	ADP
aiua-13762	112	25	developing	develop	VERB
aiua-13762	112	26	pca	pca	NOUN
aiua-13762	112	27	(	(	PUNCT
aiua-13762	112	28	50	50	NUM
aiua-13762	112	29	)	)	PUNCT
aiua-13762	112	30	,	,	PUNCT
aiua-13762	112	31	while	while	SCONJ
aiua-13762	112	32	individuals	individual	NOUN
aiua-13762	112	33	with	with	ADP
aiua-13762	112	34	a	a	DET
aiua-13762	112	35	brca2	brca2	NOUN
aiua-13762	112	36	mutation	mutation	NOUN
aiua-13762	112	37	exhibit	exhibit	VERB
aiua-13762	112	38	a	a	DET
aiua-13762	112	39	3	3	NUM
aiua-13762	112	40	-	-	SYM
aiua-13762	112	41	8fold	8fold	NUM
aiua-13762	112	42	increased	increase	VERB
aiua-13762	112	43	risk	risk	NOUN
aiua-13762	112	44	of	of	ADP
aiua-13762	112	45	pca	pca	PROPN
aiua-13762	112	46	compared	compare	VERB
aiua-13762	112	47	to	to	ADP
aiua-13762	112	48	non	non	NOUN
aiua-13762	112	49	-	-	NOUN
aiua-13762	112	50	carriers	carrier	NOUN
aiua-13762	112	51	(	(	PUNCT
aiua-13762	112	52	51	51	NUM
aiua-13762	112	53	)	)	PUNCT
aiua-13762	112	54	.	.	PUNCT
aiua-13762	113	1	approximately	approximately	ADV
aiua-13762	113	2	one	one	NUM
aiua-13762	113	3	in	in	ADP
aiua-13762	113	4	40	40	NUM
aiua-13762	113	5	aj	aj	PROPN
aiua-13762	113	6	carries	carry	VERB
aiua-13762	113	7	a	a	DET
aiua-13762	113	8	brca	brca	PROPN
aiua-13762	113	9	mutation	mutation	NOUN
aiua-13762	113	10	,	,	PUNCT
aiua-13762	113	11	to	to	ADP
aiua-13762	113	12	1	1	NUM
aiua-13762	113	13	in	in	ADP
aiua-13762	113	14	400	400	NUM
aiua-13762	113	15	in	in	ADP
aiua-13762	113	16	the	the	DET
aiua-13762	113	17	general	general	ADJ
aiua-13762	113	18	population	population	NOUN
aiua-13762	113	19	.	.	PUNCT
aiua-13762	114	1	the	the	DET
aiua-13762	114	2	brca1	brca1	PROPN
aiua-13762	114	3	185delag	185delag	PROPN
aiua-13762	114	4	and	and	CCONJ
aiua-13762	114	5	brca2	brca2	NOUN
aiua-13762	115	1	6174delt	6174delt	NUM
aiua-13762	115	2	founder	founder	NOUN
aiua-13762	115	3	mutations	mutation	NOUN
aiua-13762	115	4	are	be	AUX
aiua-13762	115	5	the	the	DET
aiua-13762	115	6	most	most	ADV
aiua-13762	115	7	common	common	ADJ
aiua-13762	115	8	deleterious	deleterious	ADJ
aiua-13762	115	9	variants	variant	NOUN
aiua-13762	115	10	predisposing	predispose	VERB
aiua-13762	115	11	to	to	ADP
aiua-13762	115	12	breast	breast	NOUN
aiua-13762	115	13	cancer	cancer	NOUN
aiua-13762	115	14	in	in	ADP
aiua-13762	115	15	ashkenazim	ashkenazim	PROPN
aiua-13762	115	16	(	(	PUNCT
aiua-13762	115	17	52	52	NUM
aiua-13762	115	18	)	)	PUNCT
aiua-13762	115	19	,	,	PUNCT
aiua-13762	115	20	though	though	SCONJ
aiua-13762	115	21	185delag	185delag	PROPN
aiua-13762	115	22	has	have	AUX
aiua-13762	115	23	been	be	AUX
aiua-13762	115	24	also	also	ADV
aiua-13762	115	25	genotyped	genotype	VERB
aiua-13762	115	26	in	in	ADP
aiua-13762	115	27	a	a	DET
aiua-13762	115	28	small	small	ADJ
aiua-13762	115	29	group	group	NOUN
aiua-13762	115	30	of	of	ADP
aiua-13762	115	31	jews	jews	PROPN
aiua-13762	115	32	of	of	ADP
aiua-13762	115	33	confirmed	confirm	VERB
aiua-13762	115	34	moroccan	moroccan	ADJ
aiua-13762	115	35	origin	origin	NOUN
aiua-13762	115	36	(	(	PUNCT
aiua-13762	115	37	53	53	NUM
aiua-13762	115	38	)	)	PUNCT
aiua-13762	115	39	.	.	PUNCT
aiua-13762	116	1	among	among	ADP
aiua-13762	116	2	ashkenazi	ashkenazi	ADJ
aiua-13762	116	3	men	man	NOUN
aiua-13762	116	4	diagnosed	diagnose	VERB
aiua-13762	116	5	with	with	ADP
aiua-13762	116	6	breast	breast	NOUN
aiua-13762	116	7	cancer	cancer	NOUN
aiua-13762	116	8	,	,	PUNCT
aiua-13762	116	9	about	about	ADV
aiua-13762	116	10	1	1	NUM
aiua-13762	116	11	in	in	ADP
aiua-13762	116	12	5	5	NUM
aiua-13762	116	13	carries	carry	VERB
aiua-13762	116	14	a	a	DET
aiua-13762	116	15	brca1	brca1	PROPN
aiua-13762	116	16	/	/	SYM
aiua-13762	116	17	brca2	brca2	NOUN
aiua-13762	116	18	inherited	inherit	VERB
aiua-13762	116	19	gene	gene	NOUN
aiua-13762	116	20	mutation	mutation	NOUN
aiua-13762	116	21	.	.	PUNCT
aiua-13762	117	1	in	in	ADP
aiua-13762	117	2	addition	addition	NOUN
aiua-13762	117	3	to	to	ADP
aiua-13762	117	4	their	their	PRON
aiua-13762	117	5	established	establish	VERB
aiua-13762	117	6	role	role	NOUN
aiua-13762	117	7	in	in	ADP
aiua-13762	117	8	breast	breast	NOUN
aiua-13762	117	9	cancer	cancer	NOUN
aiua-13762	117	10	,	,	PUNCT
aiua-13762	117	11	brca1	brca1	PROPN
aiua-13762	117	12	and	and	CCONJ
aiua-13762	117	13	brca2	brca2	PROPN
aiua-13762	117	14	founder	founder	NOUN
aiua-13762	117	15	mutations	mutation	NOUN
aiua-13762	117	16	have	have	AUX
aiua-13762	117	17	been	be	AUX
aiua-13762	117	18	associated	associate	VERB
aiua-13762	117	19	with	with	ADP
aiua-13762	117	20	reduced	reduce	VERB
aiua-13762	117	21	life	life	NOUN
aiua-13762	117	22	expectancy	expectancy	NOUN
aiua-13762	117	23	in	in	ADP
aiua-13762	117	24	aj	aj	PROPN
aiua-13762	117	25	,	,	PUNCT
aiua-13762	117	26	even	even	ADV
aiua-13762	117	27	in	in	ADP
aiua-13762	117	28	the	the	DET
aiua-13762	117	29	absence	absence	NOUN
aiua-13762	117	30	of	of	ADP
aiua-13762	117	31	cancer	cancer	NOUN
aiua-13762	117	32	(	(	PUNCT
aiua-13762	117	33	54	54	NUM
aiua-13762	117	34	)	)	PUNCT
aiua-13762	117	35	.	.	PUNCT
aiua-13762	118	1	a	a	DET
aiua-13762	118	2	1995	1995	NUM
aiua-13762	118	3	-	-	SYM
aiua-13762	118	4	1996	1996	NUM
aiua-13762	118	5	study	study	NOUN
aiua-13762	118	6	conducted	conduct	VERB
aiua-13762	118	7	at	at	ADP
aiua-13762	118	8	the	the	DET
aiua-13762	118	9	department	department	NOUN
aiua-13762	118	10	of	of	ADP
aiua-13762	118	11	oncogenetics	oncogenetic	NOUN
aiua-13762	118	12	at	at	ADP
aiua-13762	118	13	the	the	DET
aiua-13762	118	14	israeli	israeli	PROPN
aiua-13762	118	15	sheba	sheba	PROPN
aiua-13762	118	16	ramat	ramat	PROPN
aiua-13762	118	17	gan	gan	PROPN
aiua-13762	118	18	hospital	hospital	PROPN
aiua-13762	118	19	tested	test	VERB
aiua-13762	118	20	292	292	NUM
aiua-13762	118	21	women	woman	NOUN
aiua-13762	118	22	for	for	ADP
aiua-13762	118	23	mutations	mutation	NOUN
aiua-13762	118	24	associated	associate	VERB
aiua-13762	118	25	with	with	ADP
aiua-13762	118	26	breast	breast	NOUN
aiua-13762	118	27	and	and	CCONJ
aiua-13762	118	28	ovarian	ovarian	ADJ
aiua-13762	118	29	cancers	cancer	NOUN
aiua-13762	118	30	.	.	PUNCT
aiua-13762	119	1	among	among	ADP
aiua-13762	119	2	women	woman	NOUN
aiua-13762	119	3	with	with	ADP
aiua-13762	119	4	cancer	cancer	NOUN
aiua-13762	119	5	,	,	PUNCT
aiua-13762	119	6	45	45	NUM
aiua-13762	119	7	%	%	NOUN
aiua-13762	119	8	carried	carry	VERB
aiua-13762	119	9	a	a	DET
aiua-13762	119	10	founder	founder	NOUN
aiua-13762	119	11	mutation	mutation	NOUN
aiua-13762	119	12	in	in	ADP
aiua-13762	119	13	brca1/2	brca1/2	PROPN
aiua-13762	119	14	,	,	PUNCT
aiua-13762	119	15	compared	compare	VERB
aiua-13762	119	16	to	to	ADP
aiua-13762	119	17	25	25	NUM
aiua-13762	119	18	%	%	NOUN
aiua-13762	119	19	of	of	ADP
aiua-13762	119	20	healthy	healthy	ADJ
aiua-13762	119	21	individuals	individual	NOUN
aiua-13762	119	22	.	.	PUNCT
aiua-13762	120	1	specific	specific	ADJ
aiua-13762	120	2	mutations	mutation	NOUN
aiua-13762	120	3	included	include	VERB
aiua-13762	120	4	185delag	185delag	PROPN
aiua-13762	120	5	and	and	CCONJ
aiua-13762	120	6	5385insc	5385insc	NUM
aiua-13762	120	7	in	in	ADP
aiua-13762	120	8	brca1	brca1	PROPN
aiua-13762	120	9	(	(	PUNCT
aiua-13762	120	10	74.5	74.5	NUM
aiua-13762	120	11	%	%	NOUN
aiua-13762	120	12	and	and	CCONJ
aiua-13762	120	13	4.5	4.5	NUM
aiua-13762	120	14	%	%	NOUN
aiua-13762	120	15	,	,	PUNCT
aiua-13762	120	16	respectively	respectively	ADV
aiua-13762	120	17	)	)	PUNCT
aiua-13762	120	18	,	,	PUNCT
aiua-13762	120	19	and	and	CCONJ
aiua-13762	120	20	6174delt	6174delt	NUM
aiua-13762	120	21	in	in	ADP
aiua-13762	120	22	brca2	brca2	PROPN
aiua-13762	120	23	(	(	PUNCT
aiua-13762	120	24	13	13	NUM
aiua-13762	120	25	%	%	NOUN
aiua-13762	120	26	)	)	PUNCT
aiua-13762	120	27	.	.	PUNCT
aiua-13762	121	1	notably	notably	ADV
aiua-13762	121	2	,	,	PUNCT
aiua-13762	121	3	80	80	NUM
aiua-13762	121	4	%	%	NOUN
aiua-13762	121	5	of	of	ADP
aiua-13762	121	6	the	the	DET
aiua-13762	121	7	tested	test	VERB
aiua-13762	121	8	families	family	NOUN
aiua-13762	121	9	had	have	VERB
aiua-13762	121	10	first	first	ADJ
aiua-13762	121	11	-	-	PUNCT
aiua-13762	121	12	degree	degree	NOUN
aiua-13762	121	13	relatives	relative	NOUN
aiua-13762	121	14	diagnosed	diagnose	VERB
aiua-13762	121	15	with	with	ADP
aiua-13762	121	16	other	other	ADJ
aiua-13762	121	17	cancers	cancer	NOUN
aiua-13762	121	18	,	,	PUNCT
aiua-13762	121	19	including	include	VERB
aiua-13762	121	20	prostate	prostate	NOUN
aiua-13762	121	21	,	,	PUNCT
aiua-13762	121	22	colon	colon	NOUN
aiua-13762	121	23	,	,	PUNCT
aiua-13762	121	24	and	and	CCONJ
aiua-13762	121	25	lung	lung	NOUN
aiua-13762	121	26	cancers	cancer	NOUN
aiua-13762	121	27	.	.	PUNCT
aiua-13762	122	1	moreover	moreover	ADV
aiua-13762	122	2	,	,	PUNCT
aiua-13762	122	3	ten	ten	NUM
aiua-13762	122	4	close	close	ADJ
aiua-13762	122	5	relatives	relative	NOUN
aiua-13762	122	6	of	of	ADP
aiua-13762	122	7	affected	affected	ADJ
aiua-13762	122	8	patients	patient	NOUN
aiua-13762	122	9	were	be	AUX
aiua-13762	122	10	diagnosed	diagnose	VERB
aiua-13762	122	11	with	with	ADP
aiua-13762	122	12	prostate	prostate	NOUN
aiua-13762	122	13	cancer	cancer	NOUN
aiua-13762	122	14	(	(	PUNCT
aiua-13762	122	15	55	55	NUM
aiua-13762	122	16	)	)	PUNCT
aiua-13762	122	17	.	.	PUNCT
aiua-13762	123	1	brca1	brca1	PROPN
aiua-13762	123	2	and	and	CCONJ
aiua-13762	123	3	prostate	prostate	NOUN
aiua-13762	123	4	cancer	cancer	NOUN
aiua-13762	123	5	a	a	DET
aiua-13762	123	6	significant	significant	ADJ
aiua-13762	123	7	breakthrough	breakthrough	NOUN
aiua-13762	123	8	in	in	ADP
aiua-13762	123	9	understanding	understand	VERB
aiua-13762	123	10	the	the	DET
aiua-13762	123	11	relationship	relationship	NOUN
aiua-13762	123	12	between	between	ADP
aiua-13762	123	13	brca	brca	PROPN
aiua-13762	123	14	mutations	mutation	NOUN
aiua-13762	123	15	and	and	CCONJ
aiua-13762	123	16	prostate	prostate	NOUN
aiua-13762	123	17	cancer	cancer	NOUN
aiua-13762	123	18	was	be	AUX
aiua-13762	123	19	provided	provide	VERB
aiua-13762	123	20	by	by	ADP
aiua-13762	123	21	struewing	struewing	NOUN
aiua-13762	123	22	and	and	CCONJ
aiua-13762	123	23	colleagues	colleague	NOUN
aiua-13762	123	24	,	,	PUNCT
aiua-13762	123	25	who	who	PRON
aiua-13762	123	26	studied	study	VERB
aiua-13762	123	27	a	a	DET
aiua-13762	123	28	population	population	NOUN
aiua-13762	123	29	of	of	ADP
aiua-13762	123	30	5318	5318	NUM
aiua-13762	123	31	ashkenazi	ashkenazi	ADJ
aiua-13762	123	32	jewish	jewish	ADJ
aiua-13762	123	33	women	woman	NOUN
aiua-13762	123	34	and	and	CCONJ
aiua-13762	123	35	men	man	NOUN
aiua-13762	123	36	(	(	PUNCT
aiua-13762	123	37	56	56	NUM
aiua-13762	123	38	)	)	PUNCT
aiua-13762	123	39	.	.	PUNCT
aiua-13762	124	1	the	the	DET
aiua-13762	124	2	study	study	NOUN
aiua-13762	124	3	identified	identify	VERB
aiua-13762	124	4	120	120	NUM
aiua-13762	124	5	carriers	carrier	NOUN
aiua-13762	124	6	of	of	ADP
aiua-13762	124	7	brca1	brca1	PROPN
aiua-13762	124	8	(	(	PUNCT
aiua-13762	124	9	185delag	185delag	PROPN
aiua-13762	124	10	,	,	PUNCT
aiua-13762	124	11	5382insc	5382insc	NUM
aiua-13762	124	12	)	)	PUNCT
aiua-13762	124	13	and	and	CCONJ
aiua-13762	124	14	brca2	brca2	PROPN
aiua-13762	124	15	(	(	PUNCT
aiua-13762	124	16	6174delt	6174delt	PROPN
aiua-13762	124	17	)	)	PUNCT
aiua-13762	124	18	founder	founder	NOUN
aiua-13762	124	19	mutations	mutation	NOUN
aiua-13762	124	20	.	.	PUNCT
aiua-13762	125	1	women	woman	NOUN
aiua-13762	125	2	with	with	ADP
aiua-13762	125	3	brca1	brca1	PROPN
aiua-13762	125	4	and	and	CCONJ
aiua-13762	125	5	brca2	brca2	PROPN
aiua-13762	125	6	mutations	mutation	NOUN
aiua-13762	125	7	had	have	VERB
aiua-13762	125	8	an	an	DET
aiua-13762	125	9	estimated	estimate	VERB
aiua-13762	125	10	lifetime	lifetime	NOUN
aiua-13762	125	11	breast	breast	NOUN
aiua-13762	125	12	cancer	cancer	NOUN
aiua-13762	125	13	risk	risk	NOUN
aiua-13762	125	14	of	of	ADP
aiua-13762	125	15	approximately	approximately	ADV
aiua-13762	125	16	56	56	NUM
aiua-13762	125	17	-	-	SYM
aiua-13762	125	18	87	87	NUM
aiua-13762	125	19	%	%	NOUN
aiua-13762	125	20	and	and	CCONJ
aiua-13762	125	21	45	45	NUM
aiua-13762	125	22	-	-	SYM
aiua-13762	125	23	84	84	NUM
aiua-13762	125	24	%	%	NOUN
aiua-13762	125	25	,	,	PUNCT
aiua-13762	125	26	respectively	respectively	ADV
aiua-13762	125	27	.	.	PUNCT
aiua-13762	126	1	the	the	DET
aiua-13762	126	2	risk	risk	NOUN
aiua-13762	126	3	of	of	ADP
aiua-13762	126	4	ovarian	ovarian	ADJ
aiua-13762	126	5	cancer	cancer	NOUN
aiua-13762	126	6	for	for	ADP
aiua-13762	126	7	brca1	brca1	PROPN
aiua-13762	126	8	carriers	carrier	NOUN
aiua-13762	126	9	was	be	AUX
aiua-13762	126	10	estimated	estimate	VERB
aiua-13762	126	11	at	at	ADP
aiua-13762	126	12	16	16	NUM
aiua-13762	126	13	-	-	SYM
aiua-13762	126	14	54	54	NUM
aiua-13762	126	15	%	%	NOUN
aiua-13762	126	16	,	,	PUNCT
aiua-13762	126	17	while	while	SCONJ
aiua-13762	126	18	for	for	ADP
aiua-13762	126	19	brca2	brca2	NOUN
aiua-13762	126	20	carriers	carrier	NOUN
aiua-13762	126	21	it	it	PRON
aiua-13762	126	22	ranged	range	VERB
aiua-13762	126	23	between	between	ADP
aiua-13762	126	24	10	10	NUM
aiua-13762	126	25	and	and	CCONJ
aiua-13762	126	26	30	30	NUM
aiua-13762	126	27	%	%	NOUN
aiua-13762	126	28	.	.	PUNCT
aiua-13762	127	1	in	in	ADP
aiua-13762	127	2	men	man	NOUN
aiua-13762	127	3	,	,	PUNCT
aiua-13762	127	4	carriers	carrier	NOUN
aiua-13762	127	5	of	of	ADP
aiua-13762	127	6	any	any	DET
aiua-13762	127	7	brca1	brca1	NOUN
aiua-13762	127	8	or	or	CCONJ
aiua-13762	127	9	brca2	brca2	NOUN
aiua-13762	127	10	founder	founder	NOUN
aiua-13762	127	11	mutation	mutation	NOUN
aiua-13762	127	12	exhibited	exhibit	VERB
aiua-13762	127	13	a	a	DET
aiua-13762	127	14	significantly	significantly	ADV
aiua-13762	127	15	higher	high	ADJ
aiua-13762	127	16	prevalence	prevalence	NOUN
aiua-13762	127	17	of	of	ADP
aiua-13762	127	18	prostate	prostate	NOUN
aiua-13762	127	19	cancer	cancer	NOUN
aiua-13762	127	20	(	(	PUNCT
aiua-13762	127	21	14	14	NUM
aiua-13762	127	22	%	%	NOUN
aiua-13762	127	23	vs.	vs.	ADP
aiua-13762	127	24	8	8	NUM
aiua-13762	127	25	%	%	NOUN
aiua-13762	127	26	in	in	ADP
aiua-13762	127	27	noncarriers	noncarrier	NOUN
aiua-13762	127	28	,	,	PUNCT
aiua-13762	127	29	p	p	X
aiua-13762	127	30	<	<	X
aiua-13762	127	31	0.01	0.01	NUM
aiua-13762	127	32	)	)	PUNCT
aiua-13762	127	33	.	.	PUNCT
aiua-13762	128	1	this	this	DET
aiua-13762	128	2	study	study	NOUN
aiua-13762	128	3	concluded	conclude	VERB
aiua-13762	128	4	that	that	SCONJ
aiua-13762	128	5	specific	specific	ADJ
aiua-13762	128	6	brca1	brca1	NOUN
aiua-13762	128	7	and	and	CCONJ
aiua-13762	128	8	brca2	brca2	NOUN
aiua-13762	128	9	mutations	mutation	NOUN
aiua-13762	128	10	can	can	AUX
aiua-13762	128	11	significantly	significantly	ADV
aiua-13762	128	12	increase	increase	VERB
aiua-13762	128	13	the	the	DET
aiua-13762	128	14	risk	risk	NOUN
aiua-13762	128	15	of	of	ADP
aiua-13762	128	16	breast	breast	NOUN
aiua-13762	128	17	,	,	PUNCT
aiua-13762	128	18	ovarian	ovarian	ADJ
aiua-13762	128	19	,	,	PUNCT
aiua-13762	128	20	and	and	CCONJ
aiua-13762	128	21	prostate	prostate	NOUN
aiua-13762	128	22	cancers	cancer	NOUN
aiua-13762	128	23	in	in	ADP
aiua-13762	128	24	aj	aj	PROPN
aiua-13762	128	25	.	.	PROPN
aiua-13762	129	1	giusti	giusti	PROPN
aiua-13762	129	2	and	and	CCONJ
aiua-13762	129	3	colleagues	colleague	NOUN
aiua-13762	129	4	examined	examine	VERB
aiua-13762	129	5	medical	medical	ADJ
aiua-13762	129	6	records	record	NOUN
aiua-13762	129	7	of	of	ADP
aiua-13762	129	8	pca	pca	NOUN
aiua-13762	129	9	patients	patient	NOUN
aiua-13762	129	10	from	from	ADP
aiua-13762	129	11	23	23	NUM
aiua-13762	129	12	israeli	israeli	ADJ
aiua-13762	129	13	hospitals	hospital	NOUN
aiua-13762	129	14	during	during	ADP
aiua-13762	129	15	the	the	DET
aiua-13762	129	16	early	early	ADJ
aiua-13762	129	17	psa	psa	NOUN
aiua-13762	129	18	era	era	NOUN
aiua-13762	129	19	(	(	PUNCT
aiua-13762	129	20	1994	1994	NUM
aiua-13762	129	21	-	-	SYM
aiua-13762	129	22	1995	1995	NUM
aiua-13762	129	23	)	)	PUNCT
aiua-13762	129	24	.	.	PUNCT
aiua-13762	130	1	by	by	ADP
aiua-13762	130	2	combining	combine	VERB
aiua-13762	130	3	this	this	DET
aiua-13762	130	4	israeli	israeli	ADJ
aiua-13762	130	5	dataset	dataset	NOUN
aiua-13762	130	6	(	(	PUNCT
aiua-13762	130	7	n	n	NOUN
aiua-13762	130	8	=	=	NOUN
aiua-13762	130	9	940	940	NUM
aiua-13762	130	10	)	)	PUNCT
aiua-13762	130	11	with	with	ADP
aiua-13762	130	12	data	datum	NOUN
aiua-13762	130	13	from	from	ADP
aiua-13762	130	14	the	the	DET
aiua-13762	130	15	washington	washington	PROPN
aiua-13762	130	16	ashkenazi	ashkenazi	PROPN
aiua-13762	130	17	study	study	PROPN
aiua-13762	130	18	(	(	PUNCT
aiua-13762	130	19	n	n	NOUN
aiua-13762	130	20	=	=	SYM
aiua-13762	130	21	872	872	NUM
aiua-13762	130	22	)	)	PUNCT
aiua-13762	130	23	,	,	PUNCT
aiua-13762	130	24	the	the	DET
aiua-13762	130	25	authors	author	NOUN
aiua-13762	130	26	calculated	calculate	VERB
aiua-13762	130	27	a	a	DET
aiua-13762	130	28	significant	significant	ADJ
aiua-13762	130	29	odds	odd	NOUN
aiua-13762	130	30	ratio	ratio	NOUN
aiua-13762	130	31	of	of	ADP
aiua-13762	130	32	2.18	2.18	NUM
aiua-13762	130	33	for	for	ADP
aiua-13762	130	34	prostate	prostate	NOUN
aiua-13762	130	35	cancer	cancer	NOUN
aiua-13762	130	36	in	in	ADP
aiua-13762	130	37	carriers	carrier	NOUN
aiua-13762	130	38	of	of	ADP
aiua-13762	130	39	any	any	DET
aiua-13762	130	40	brca	brca	PROPN
aiua-13762	130	41	founder	founder	NOUN
aiua-13762	130	42	mutation	mutation	NOUN
aiua-13762	130	43	(	(	PUNCT
aiua-13762	130	44	95	95	NUM
aiua-13762	130	45	%	%	NOUN
aiua-13762	130	46	ci	ci	NOUN
aiua-13762	130	47	,	,	PUNCT
aiua-13762	130	48	1.09	1.09	NUM
aiua-13762	130	49	-	-	SYM
aiua-13762	130	50	4.43	4.43	NUM
aiua-13762	130	51	)	)	PUNCT
aiua-13762	130	52	.	.	PUNCT
aiua-13762	131	1	however	however	ADV
aiua-13762	131	2	,	,	PUNCT
aiua-13762	131	3	the	the	DET
aiua-13762	131	4	odds	odd	NOUN
aiua-13762	131	5	ratios	ratio	NOUN
aiua-13762	131	6	for	for	ADP
aiua-13762	131	7	individual	individual	ADJ
aiua-13762	131	8	brca1	brca1	PROPN
aiua-13762	131	9	or	or	CCONJ
aiua-13762	131	10	brca2	brca2	NOUN
aiua-13762	131	11	mutations	mutation	NOUN
aiua-13762	131	12	were	be	AUX
aiua-13762	131	13	not	not	PART
aiua-13762	131	14	statistically	statistically	ADV
aiua-13762	131	15	significant	significant	ADJ
aiua-13762	131	16	(	(	PUNCT
aiua-13762	131	17	57	57	NUM
aiua-13762	131	18	)	)	PUNCT
aiua-13762	131	19	.	.	PUNCT
aiua-13762	132	1	in	in	ADP
aiua-13762	132	2	a	a	DET
aiua-13762	132	3	separate	separate	ADJ
aiua-13762	132	4	study	study	NOUN
aiua-13762	132	5	on	on	ADP
aiua-13762	132	6	the	the	DET
aiua-13762	132	7	impact	impact	NOUN
aiua-13762	132	8	of	of	ADP
aiua-13762	132	9	brca1	brca1	PROPN
aiua-13762	132	10	5382insc	5382insc	PROPN
aiua-13762	132	11	on	on	ADP
aiua-13762	132	12	prostate	prostate	NOUN
aiua-13762	132	13	cancer	cancer	NOUN
aiua-13762	132	14	,	,	PUNCT
aiua-13762	132	15	vazina	vazina	NOUN
aiua-13762	132	16	and	and	CCONJ
aiua-13762	132	17	colleagues	colleague	NOUN
aiua-13762	132	18	assessed	assess	VERB
aiua-13762	132	19	a	a	DET
aiua-13762	132	20	subset	subset	NOUN
aiua-13762	132	21	of	of	ADP
aiua-13762	132	22	95	95	NUM
aiua-13762	132	23	ashkenazi	ashkenazi	ADJ
aiua-13762	132	24	patients	patient	NOUN
aiua-13762	132	25	(	(	PUNCT
aiua-13762	132	26	58	58	NUM
aiua-13762	132	27	)	)	PUNCT
aiua-13762	132	28	.	.	PUNCT
aiua-13762	133	1	the	the	DET
aiua-13762	133	2	authors	author	NOUN
aiua-13762	133	3	found	find	VERB
aiua-13762	133	4	that	that	SCONJ
aiua-13762	133	5	the	the	DET
aiua-13762	133	6	detection	detection	NOUN
aiua-13762	133	7	rate	rate	NOUN
aiua-13762	133	8	of	of	ADP
aiua-13762	133	9	5382insc	5382insc	NUM
aiua-13762	133	10	among	among	ADP
aiua-13762	133	11	pca	pca	NOUN
aiua-13762	133	12	patients	patient	NOUN
aiua-13762	133	13	was	be	AUX
aiua-13762	133	14	significantly	significantly	ADV
aiua-13762	133	15	higher	high	ADJ
aiua-13762	133	16	than	than	ADP
aiua-13762	133	17	in	in	ADP
aiua-13762	133	18	the	the	DET
aiua-13762	133	19	general	general	ADJ
aiua-13762	133	20	population	population	NOUN
aiua-13762	133	21	analyzed	analyze	VERB
aiua-13762	133	22	in	in	ADP
aiua-13762	133	23	the	the	DET
aiua-13762	133	24	study	study	NOUN
aiua-13762	133	25	by	by	ADP
aiua-13762	133	26	struewing	struewe	VERB
aiua-13762	133	27	et	et	PROPN
aiua-13762	133	28	al	al	PROPN
aiua-13762	133	29	.	.	PUNCT
aiua-13762	134	1	(	(	PUNCT
aiua-13762	134	2	3.3	3.3	NUM
aiua-13762	134	3	%	%	NOUN
aiua-13762	134	4	vs.	vs.	ADP
aiua-13762	134	5	0.37	0.37	NUM
aiua-13762	134	6	%	%	NOUN
aiua-13762	134	7	,	,	PUNCT
aiua-13762	134	8	p	p	X
aiua-13762	134	9	=	=	NOUN
aiua-13762	134	10	0.02	0.02	NUM
aiua-13762	134	11	)	)	PUNCT
aiua-13762	134	12	.	.	PUNCT
aiua-13762	135	1	despite	despite	SCONJ
aiua-13762	135	2	the	the	DET
aiua-13762	135	3	limitations	limitation	NOUN
aiua-13762	135	4	due	due	ADP
aiua-13762	135	5	to	to	ADP
aiua-13762	135	6	its	its	PRON
aiua-13762	135	7	small	small	ADJ
aiua-13762	135	8	sample	sample	NOUN
aiua-13762	135	9	size	size	NOUN
aiua-13762	135	10	and	and	CCONJ
aiua-13762	135	11	to	to	ADP
aiua-13762	135	12	the	the	DET
aiua-13762	135	13	use	use	NOUN
aiua-13762	135	14	of	of	ADP
aiua-13762	135	15	external	external	ADJ
aiua-13762	135	16	controls	control	NOUN
aiua-13762	135	17	(	(	PUNCT
aiua-13762	135	18	59	59	NUM
aiua-13762	135	19	)	)	PUNCT
aiua-13762	135	20	,	,	PUNCT
aiua-13762	135	21	this	this	DET
aiua-13762	135	22	study	study	NOUN
aiua-13762	135	23	supports	support	VERB
aiua-13762	135	24	the	the	DET
aiua-13762	135	25	hypothesis	hypothesis	NOUN
aiua-13762	135	26	that	that	PRON
aiua-13762	135	27	brca1	brca1	PROPN
aiua-13762	135	28	5382insc	5382insc	PROPN
aiua-13762	135	29	may	may	AUX
aiua-13762	135	30	contribute	contribute	VERB
aiua-13762	135	31	to	to	ADP
aiua-13762	135	32	prostate	prostate	NOUN
aiua-13762	135	33	cancer	cancer	NOUN
aiua-13762	135	34	risk	risk	NOUN
aiua-13762	135	35	.	.	PUNCT
aiua-13762	136	1	a	a	DET
aiua-13762	136	2	key	key	ADJ
aiua-13762	136	3	question	question	NOUN
aiua-13762	136	4	is	be	AUX
aiua-13762	136	5	whether	whether	SCONJ
aiua-13762	136	6	somatic	somatic	ADJ
aiua-13762	136	7	mutations	mutation	NOUN
aiua-13762	136	8	in	in	ADP
aiua-13762	136	9	oncogenes	oncogene	NOUN
aiua-13762	136	10	or	or	CCONJ
aiua-13762	136	11	tumor	tumor	NOUN
aiua-13762	136	12	suppressor	suppressor	NOUN
aiua-13762	136	13	genes	gene	NOUN
aiua-13762	136	14	can	can	AUX
aiua-13762	136	15	modulate	modulate	VERB
aiua-13762	136	16	the	the	DET
aiua-13762	136	17	phenotype	phenotype	NOUN
aiua-13762	136	18	of	of	ADP
aiua-13762	136	19	prostate	prostate	NOUN
aiua-13762	136	20	cancer	cancer	NOUN
aiua-13762	136	21	in	in	ADP
aiua-13762	136	22	individuals	individual	NOUN
aiua-13762	136	23	harboring	harbor	VERB
aiua-13762	136	24	brca	brca	PROPN
aiua-13762	136	25	mutations	mutation	NOUN
aiua-13762	136	26	.	.	PUNCT
aiua-13762	137	1	nickerson	nickerson	PROPN
aiua-13762	137	2	and	and	CCONJ
aiua-13762	137	3	colleagues	colleague	NOUN
aiua-13762	137	4	examined	examine	VERB
aiua-13762	137	5	the	the	DET
aiua-13762	137	6	molecular	molecular	ADJ
aiua-13762	137	7	makeup	makeup	NOUN
aiua-13762	137	8	of	of	ADP
aiua-13762	137	9	metastatic	metastatic	ADJ
aiua-13762	137	10	castration	castration	NOUN
aiua-13762	137	11	-	-	PUNCT
aiua-13762	137	12	resistant	resistant	ADJ
aiua-13762	137	13	prostate	prostate	NOUN
aiua-13762	137	14	cancer	cancer	NOUN
aiua-13762	137	15	(	(	PUNCT
aiua-13762	137	16	crpc	crpc	ADJ
aiua-13762	137	17	)	)	PUNCT
aiua-13762	137	18	in	in	ADP
aiua-13762	137	19	an	an	DET
aiua-13762	137	20	ashkenazi	ashkenazi	ADJ
aiua-13762	137	21	carrier	carrier	NOUN
aiua-13762	137	22	of	of	ADP
aiua-13762	137	23	brca1	brca1	PROPN
aiua-13762	137	24	185delag	185delag	PROPN
aiua-13762	137	25	.	.	PUNCT
aiua-13762	138	1	notably	notably	ADV
aiua-13762	138	2	,	,	PUNCT
aiua-13762	138	3	all	all	DET
aiua-13762	138	4	metastases	metastasis	NOUN
aiua-13762	138	5	analyzed	analyze	VERB
aiua-13762	138	6	(	(	PUNCT
aiua-13762	138	7	n	n	NOUN
aiua-13762	138	8	=	=	SYM
aiua-13762	138	9	11	11	NUM
aiua-13762	138	10	)	)	PUNCT
aiua-13762	138	11	showed	show	VERB
aiua-13762	138	12	somatic	somatic	ADJ
aiua-13762	138	13	loss	loss	NOUN
aiua-13762	138	14	of	of	ADP
aiua-13762	138	15	heterozygosity	heterozygosity	NOUN
aiua-13762	138	16	.	.	PUNCT
aiua-13762	139	1	the	the	DET
aiua-13762	139	2	study	study	NOUN
aiua-13762	139	3	also	also	ADV
aiua-13762	139	4	reported	report	VERB
aiua-13762	139	5	62	62	NUM
aiua-13762	139	6	somatic	somatic	ADJ
aiua-13762	139	7	non	non	ADJ
aiua-13762	139	8	-	-	ADJ
aiua-13762	139	9	synonymous	synonymous	ADJ
aiua-13762	139	10	mutations	mutation	NOUN
aiua-13762	139	11	in	in	ADP
aiua-13762	139	12	genes	gene	NOUN
aiua-13762	139	13	implicated	implicate	VERB
aiua-13762	139	14	in	in	ADP
aiua-13762	139	15	cancer	cancer	NOUN
aiua-13762	139	16	progression	progression	NOUN
aiua-13762	139	17	and	and	CCONJ
aiua-13762	139	18	metastasis	metastasis	NOUN
aiua-13762	139	19	,	,	PUNCT
aiua-13762	139	20	including	include	VERB
aiua-13762	139	21	tp53	tp53	PROPN
aiua-13762	139	22	(	(	PUNCT
aiua-13762	139	23	frequently	frequently	ADV
aiua-13762	139	24	altered	alter	VERB
aiua-13762	139	25	in	in	ADP
aiua-13762	139	26	metastatic	metastatic	ADJ
aiua-13762	139	27	crpc	crpc	NOUN
aiua-13762	139	28	)	)	PUNCT
aiua-13762	139	29	,	,	PUNCT
aiua-13762	139	30	pten	pten	NOUN
aiua-13762	139	31	(	(	PUNCT
aiua-13762	139	32	whose	whose	DET
aiua-13762	139	33	loss	loss	NOUN
aiua-13762	139	34	is	be	AUX
aiua-13762	139	35	associated	associate	VERB
aiua-13762	139	36	with	with	ADP
aiua-13762	139	37	tumor	tumor	NOUN
aiua-13762	139	38	aggressiveness	aggressiveness	NOUN
aiua-13762	139	39	)	)	PUNCT
aiua-13762	139	40	,	,	PUNCT
aiua-13762	139	41	the	the	DET
aiua-13762	139	42	androgen	androgen	NOUN
aiua-13762	139	43	receptor	receptor	NOUN
aiua-13762	139	44	(	(	PUNCT
aiua-13762	139	45	whose	whose	DET
aiua-13762	139	46	mutations	mutation	NOUN
aiua-13762	139	47	and	and	CCONJ
aiua-13762	139	48	amplifications	amplification	NOUN
aiua-13762	139	49	are	be	AUX
aiua-13762	139	50	crucial	crucial	ADJ
aiua-13762	139	51	for	for	ADP
aiua-13762	139	52	castration	castration	NOUN
aiua-13762	139	53	resistance	resistance	NOUN
aiua-13762	139	54	)	)	PUNCT
aiua-13762	139	55	,	,	PUNCT
aiua-13762	139	56	kmt2c	kmt2c	X
aiua-13762	139	57	(	(	PUNCT
aiua-13762	139	58	playing	play	VERB
aiua-13762	139	59	a	a	DET
aiua-13762	139	60	role	role	NOUN
aiua-13762	139	61	in	in	ADP
aiua-13762	139	62	crpc	crpc	ADJ
aiua-13762	139	63	progression	progression	NOUN
aiua-13762	139	64	)	)	PUNCT
aiua-13762	139	65	,	,	PUNCT
aiua-13762	139	66	and	and	CCONJ
aiua-13762	139	67	fat1	fat1	PROPN
aiua-13762	139	68	(	(	PUNCT
aiua-13762	139	69	linked	link	VERB
aiua-13762	139	70	to	to	ADP
aiua-13762	139	71	the	the	DET
aiua-13762	139	72	metastatic	metastatic	ADJ
aiua-13762	139	73	phenotype	phenotype	NOUN
aiua-13762	139	74	)	)	PUNCT
aiua-13762	139	75	.	.	PUNCT
aiua-13762	140	1	the	the	DET
aiua-13762	140	2	tet2	tet2	PROPN
aiua-13762	140	3	gene	gene	NOUN
aiua-13762	140	4	,	,	PUNCT
aiua-13762	140	5	whose	whose	DET
aiua-13762	140	6	loss	loss	NOUN
aiua-13762	140	7	of	of	ADP
aiua-13762	140	8	function	function	NOUN
aiua-13762	140	9	is	be	AUX
aiua-13762	140	10	associated	associate	VERB
aiua-13762	140	11	with	with	ADP
aiua-13762	140	12	epigenetic	epigenetic	ADJ
aiua-13762	140	13	changes	change	NOUN
aiua-13762	140	14	in	in	ADP
aiua-13762	140	15	cancer	cancer	NOUN
aiua-13762	140	16	,	,	PUNCT
aiua-13762	140	17	was	be	AUX
aiua-13762	140	18	also	also	ADV
aiua-13762	140	19	altered	alter	VERB
aiua-13762	140	20	(	(	PUNCT
aiua-13762	140	21	60	60	NUM
aiua-13762	140	22	)	)	PUNCT
aiua-13762	140	23	.	.	PUNCT
aiua-13762	141	1	these	these	DET
aiua-13762	141	2	findings	finding	NOUN
aiua-13762	141	3	suggest	suggest	VERB
aiua-13762	141	4	that	that	SCONJ
aiua-13762	141	5	somatic	somatic	ADJ
aiua-13762	141	6	mutations	mutation	NOUN
aiua-13762	141	7	may	may	AUX
aiua-13762	141	8	play	play	VERB
aiua-13762	141	9	a	a	DET
aiua-13762	141	10	crucial	crucial	ADJ
aiua-13762	141	11	role	role	NOUN
aiua-13762	141	12	in	in	ADP
aiua-13762	141	13	crpc	crpc	ADV
aiua-13762	141	14	in	in	ADP
aiua-13762	141	15	ashkenazi	ashkenazi	ADJ
aiua-13762	141	16	individuals	individual	NOUN
aiua-13762	141	17	with	with	ADP
aiua-13762	141	18	brca1	brca1	PROPN
aiua-13762	141	19	founder	founder	NOUN
aiua-13762	141	20	mutations	mutation	NOUN
aiua-13762	141	21	.	.	PUNCT
aiua-13762	142	1	if	if	SCONJ
aiua-13762	142	2	confirmed	confirm	VERB
aiua-13762	142	3	by	by	ADP
aiua-13762	142	4	larger	large	ADJ
aiua-13762	142	5	studies	study	NOUN
aiua-13762	142	6	,	,	PUNCT
aiua-13762	142	7	these	these	DET
aiua-13762	142	8	results	result	NOUN
aiua-13762	142	9	could	could	AUX
aiua-13762	142	10	provide	provide	VERB
aiua-13762	142	11	valuable	valuable	ADJ
aiua-13762	142	12	insights	insight	NOUN
aiua-13762	142	13	into	into	ADP
aiua-13762	142	14	the	the	DET
aiua-13762	142	15	molecular	molecular	ADJ
aiua-13762	142	16	mechanisms	mechanism	NOUN
aiua-13762	142	17	driving	drive	VERB
aiua-13762	142	18	hereditary	hereditary	ADJ
aiua-13762	142	19	prostate	prostate	NOUN
aiua-13762	142	20	cancer	cancer	NOUN
aiua-13762	142	21	and	and	CCONJ
aiua-13762	142	22	suggest	suggest	VERB
aiua-13762	142	23	potential	potential	ADJ
aiua-13762	142	24	diagnostic	diagnostic	ADJ
aiua-13762	142	25	or	or	CCONJ
aiua-13762	142	26	therapeutic	therapeutic	ADJ
aiua-13762	142	27	targets	target	NOUN
aiua-13762	142	28	.	.	PUNCT
aiua-13762	143	1	brca2	brca2	NOUN
aiua-13762	143	2	and	and	CCONJ
aiua-13762	143	3	prostate	prostate	NOUN
aiua-13762	143	4	cancer	cancer	NOUN
aiua-13762	143	5	brca2	brca2	NOUN
aiua-13762	143	6	harbors	harbor	VERB
aiua-13762	143	7	a	a	DET
aiua-13762	143	8	pca	pca	PROPN
aiua-13762	143	9	cluster	cluster	NOUN
aiua-13762	143	10	region	region	NOUN
aiua-13762	143	11	containing	contain	VERB
aiua-13762	143	12	two	two	NUM
aiua-13762	143	13	separate	separate	ADJ
aiua-13762	143	14	domains	domain	NOUN
aiua-13762	143	15	linked	link	VERB
aiua-13762	143	16	to	to	ADP
aiua-13762	143	17	increased	increase	VERB
aiua-13762	143	18	risk	risk	NOUN
aiua-13762	143	19	of	of	ADP
aiua-13762	143	20	pca	pca	NOUN
aiua-13762	143	21	,	,	PUNCT
aiua-13762	143	22	namely	namely	ADV
aiua-13762	143	23	the	the	DET
aiua-13762	143	24	ob1	ob1	NOUN
aiua-13762	143	25	oligonucleotide	oligonucleotide	NOUN
aiua-13762	143	26	-	-	PUNCT
aiua-13762	143	27	olisaccharide	olisaccharide	NOUN
aiua-13762	143	28	binding	bind	VERB
aiua-13762	143	29	domain	domain	NOUN
aiua-13762	143	30	and	and	CCONJ
aiua-13762	143	31	the	the	DET
aiua-13762	143	32	ob2	ob2	NOUN
aiua-13762	143	33	tower	tower	NOUN
aiua-13762	143	34	dna	dna	NOUN
aiua-13762	143	35	binding	bind	VERB
aiua-13762	143	36	domain	domain	NOUN
aiua-13762	143	37	(	(	PUNCT
aiua-13762	143	38	61	61	NUM
aiua-13762	143	39	)	)	PUNCT
aiua-13762	143	40	.	.	PUNCT
aiua-13762	144	1	kirchhoff	kirchhoff	NOUN
aiua-13762	144	2	and	and	CCONJ
aiua-13762	144	3	colleagues	colleague	NOUN
aiua-13762	144	4	compared	compare	VERB
aiua-13762	144	5	the	the	DET
aiua-13762	144	6	prevalence	prevalence	NOUN
aiua-13762	144	7	of	of	ADP
aiua-13762	144	8	the	the	DET
aiua-13762	144	9	three	three	NUM
aiua-13762	144	10	ashkenazi	ashkenazi	ADJ
aiua-13762	144	11	founder	founder	NOUN
aiua-13762	144	12	mutations	mutation	NOUN
aiua-13762	144	13	-185delag	-185delag	PROPN
aiua-13762	144	14	and	and	CCONJ
aiua-13762	144	15	5382insc	5382insc	NUM
aiua-13762	144	16	in	in	ADP
aiua-13762	144	17	brca1	brca1	PROPN
aiua-13762	144	18	,	,	PUNCT
aiua-13762	144	19	and	and	CCONJ
aiua-13762	144	20	6174delt	6174delt	NUM
aiua-13762	144	21	in	in	ADP
aiua-13762	144	22	brca2among	brca2among	NOUN
aiua-13762	144	23	251	251	NUM
aiua-13762	144	24	unselected	unselected	ADJ
aiua-13762	144	25	ashkenazi	ashkenazi	ADJ
aiua-13762	144	26	men	man	NOUN
aiua-13762	144	27	with	with	ADP
aiua-13762	144	28	pca	pca	PROPN
aiua-13762	144	29	and	and	CCONJ
aiua-13762	144	30	1472	1472	NUM
aiua-13762	144	31	archivio	archivio	NOUN
aiua-13762	144	32	italiano	italiano	X
aiua-13762	144	33	di	di	X
aiua-13762	144	34	urologia	urologia	PROPN
aiua-13762	144	35	e	e	PROPN
aiua-13762	144	36	andrologia	andrologia	NOUN
aiua-13762	144	37	2025	2025	NUM
aiua-13762	144	38	;	;	PUNCT
aiua-13762	144	39	97(2):13762	97(2):13762	NUM
aiua-13762	144	40	5	5	NUM
aiua-13762	144	41	genetic	genetic	ADJ
aiua-13762	144	42	of	of	ADP
aiua-13762	144	43	prostate	prostate	NOUN
aiua-13762	144	44	cancer	cancer	NOUN
aiua-13762	144	45	healthy	healthy	ADJ
aiua-13762	144	46	ashkenazi	ashkenazi	PROPN
aiua-13762	144	47	controls	control	NOUN
aiua-13762	144	48	.	.	PUNCT
aiua-13762	145	1	the	the	DET
aiua-13762	145	2	age	age	NOUN
aiua-13762	145	3	-	-	PUNCT
aiua-13762	145	4	adjusted	adjust	VERB
aiua-13762	145	5	odds	odd	NOUN
aiua-13762	145	6	ratio	ratio	NOUN
aiua-13762	145	7	for	for	ADP
aiua-13762	145	8	pca	pca	NOUN
aiua-13762	145	9	in	in	ADP
aiua-13762	145	10	carriers	carrier	NOUN
aiua-13762	145	11	of	of	ADP
aiua-13762	145	12	any	any	DET
aiua-13762	145	13	mutation	mutation	NOUN
aiua-13762	145	14	was	be	AUX
aiua-13762	145	15	3.41	3.41	NUM
aiua-13762	145	16	(	(	PUNCT
aiua-13762	145	17	95	95	NUM
aiua-13762	145	18	%	%	NOUN
aiua-13762	145	19	ci	ci	NOUN
aiua-13762	145	20	,	,	PUNCT
aiua-13762	145	21	1.64	1.64	NUM
aiua-13762	145	22	-	-	SYM
aiua-13762	145	23	7.06	7.06	NUM
aiua-13762	145	24	)	)	PUNCT
aiua-13762	145	25	.	.	PUNCT
aiua-13762	146	1	statistical	statistical	ADJ
aiua-13762	146	2	significance	significance	NOUN
aiua-13762	146	3	was	be	AUX
aiua-13762	146	4	primarily	primarily	ADV
aiua-13762	146	5	driven	drive	VERB
aiua-13762	146	6	by	by	ADP
aiua-13762	146	7	carriers	carrier	NOUN
aiua-13762	146	8	of	of	ADP
aiua-13762	146	9	the	the	DET
aiua-13762	146	10	brca2	brca2	NOUN
aiua-13762	146	11	6174delt	6174delt	NUM
aiua-13762	146	12	mutation	mutation	NOUN
aiua-13762	146	13	,	,	PUNCT
aiua-13762	146	14	whose	whose	DET
aiua-13762	146	15	odds	odd	NOUN
aiua-13762	146	16	of	of	ADP
aiua-13762	146	17	developing	develop	VERB
aiua-13762	146	18	pca	pca	PROPN
aiua-13762	146	19	were	be	AUX
aiua-13762	146	20	nearly	nearly	ADV
aiua-13762	146	21	five	five	NUM
aiua-13762	146	22	times	time	NOUN
aiua-13762	146	23	greater	great	ADJ
aiua-13762	146	24	compared	compare	VERB
aiua-13762	146	25	to	to	ADP
aiua-13762	146	26	controls	control	NOUN
aiua-13762	146	27	(	(	PUNCT
aiua-13762	146	28	or	or	CCONJ
aiua-13762	146	29	,	,	PUNCT
aiua-13762	146	30	4.78	4.78	NUM
aiua-13762	146	31	;	;	PUNCT
aiua-13762	146	32	95	95	NUM
aiua-13762	146	33	%	%	NOUN
aiua-13762	146	34	ci	ci	NOUN
aiua-13762	146	35	,	,	PUNCT
aiua-13762	146	36	1.87	1.87	NUM
aiua-13762	146	37	-	-	SYM
aiua-13762	146	38	12.25	12.25	NUM
aiua-13762	146	39	)	)	PUNCT
aiua-13762	146	40	.	.	PUNCT
aiua-13762	147	1	in	in	ADP
aiua-13762	147	2	contrast	contrast	NOUN
aiua-13762	147	3	,	,	PUNCT
aiua-13762	147	4	the	the	DET
aiua-13762	147	5	odds	odd	NOUN
aiua-13762	147	6	ratio	ratio	NOUN
aiua-13762	147	7	for	for	ADP
aiua-13762	147	8	a	a	DET
aiua-13762	147	9	brca1	brca1	NOUN
aiua-13762	147	10	mutation	mutation	NOUN
aiua-13762	147	11	did	do	AUX
aiua-13762	147	12	not	not	PART
aiua-13762	147	13	reach	reach	VERB
aiua-13762	147	14	statistical	statistical	ADJ
aiua-13762	147	15	significance	significance	NOUN
aiua-13762	147	16	(	(	PUNCT
aiua-13762	147	17	or	or	CCONJ
aiua-13762	147	18	,	,	PUNCT
aiua-13762	147	19	2.2	2.2	NUM
aiua-13762	147	20	;	;	PUNCT
aiua-13762	147	21	95	95	NUM
aiua-13762	147	22	%	%	NOUN
aiua-13762	147	23	ci	ci	NOUN
aiua-13762	147	24	,	,	PUNCT
aiua-13762	147	25	0.72	0.72	NUM
aiua-13762	147	26	-	-	SYM
aiua-13762	147	27	6.7	6.7	NUM
aiua-13762	147	28	)	)	PUNCT
aiua-13762	147	29	(	(	PUNCT
aiua-13762	147	30	62	62	NUM
aiua-13762	147	31	)	)	PUNCT
aiua-13762	147	32	.	.	PUNCT
aiua-13762	148	1	in	in	ADP
aiua-13762	148	2	a	a	DET
aiua-13762	148	3	subsequent	subsequent	ADJ
aiua-13762	148	4	study	study	NOUN
aiua-13762	148	5	by	by	ADP
aiua-13762	148	6	gallagher	gallagher	PROPN
aiua-13762	148	7	and	and	CCONJ
aiua-13762	148	8	colleagues	colleague	NOUN
aiua-13762	148	9	,	,	PUNCT
aiua-13762	148	10	comparing	compare	VERB
aiua-13762	148	11	832	832	NUM
aiua-13762	148	12	aj	aj	PROPN
aiua-13762	148	13	pca	pca	PROPN
aiua-13762	148	14	patients	patient	NOUN
aiua-13762	148	15	with	with	ADP
aiua-13762	148	16	454	454	NUM
aiua-13762	148	17	healthy	healthy	ADJ
aiua-13762	148	18	aj	aj	PROPN
aiua-13762	148	19	controls	control	NOUN
aiua-13762	148	20	,	,	PUNCT
aiua-13762	148	21	the	the	DET
aiua-13762	148	22	odds	odd	NOUN
aiua-13762	148	23	ratio	ratio	NOUN
aiua-13762	148	24	for	for	ADP
aiua-13762	148	25	pca	pca	NOUN
aiua-13762	148	26	in	in	ADP
aiua-13762	148	27	carriers	carrier	NOUN
aiua-13762	148	28	of	of	ADP
aiua-13762	148	29	brca2	brca2	PROPN
aiua-13762	148	30	6174delt	6174delt	PROPN
aiua-13762	148	31	was	be	AUX
aiua-13762	148	32	3.10	3.10	NUM
aiua-13762	148	33	(	(	PUNCT
aiua-13762	148	34	95	95	NUM
aiua-13762	148	35	%	%	NOUN
aiua-13762	148	36	ci	ci	NOUN
aiua-13762	148	37	,	,	PUNCT
aiua-13762	148	38	1.52	1.52	NUM
aiua-13762	148	39	-	-	SYM
aiua-13762	148	40	6.66	6.66	NUM
aiua-13762	148	41	)	)	PUNCT
aiua-13762	148	42	,	,	PUNCT
aiua-13762	148	43	while	while	SCONJ
aiua-13762	148	44	the	the	DET
aiua-13762	148	45	odds	odd	NOUN
aiua-13762	148	46	ratio	ratio	NOUN
aiua-13762	148	47	for	for	ADP
aiua-13762	148	48	carriers	carrier	NOUN
aiua-13762	148	49	of	of	ADP
aiua-13762	148	50	brca1	brca1	PROPN
aiua-13762	148	51	185delag	185delag	PROPN
aiua-13762	148	52	was	be	AUX
aiua-13762	148	53	not	not	PART
aiua-13762	148	54	significant	significant	ADJ
aiua-13762	148	55	(	(	PUNCT
aiua-13762	148	56	or	or	CCONJ
aiua-13762	148	57	,	,	PUNCT
aiua-13762	148	58	0.38	0.38	NUM
aiua-13762	148	59	;	;	PUNCT
aiua-13762	148	60	95	95	NUM
aiua-13762	148	61	%	%	NOUN
aiua-13762	148	62	ci	ci	NOUN
aiua-13762	148	63	,	,	PUNCT
aiua-13762	148	64	0.05	0.05	NUM
aiua-13762	148	65	-	-	SYM
aiua-13762	148	66	2.75	2.75	NUM
aiua-13762	148	67	)	)	PUNCT
aiua-13762	148	68	(	(	PUNCT
aiua-13762	148	69	63	63	NUM
aiua-13762	148	70	)	)	PUNCT
aiua-13762	148	71	.	.	PUNCT
aiua-13762	149	1	notably	notably	ADV
aiua-13762	149	2	,	,	PUNCT
aiua-13762	149	3	a	a	DET
aiua-13762	149	4	significantly	significantly	ADV
aiua-13762	149	5	higher	high	ADJ
aiua-13762	149	6	proportion	proportion	NOUN
aiua-13762	149	7	of	of	ADP
aiua-13762	149	8	brca2	brca2	NOUN
aiua-13762	149	9	6174delt	6174delt	NUM
aiua-13762	149	10	carriers	carrier	NOUN
aiua-13762	149	11	had	have	VERB
aiua-13762	149	12	high	high	ADJ
aiua-13762	149	13	-	-	PUNCT
aiua-13762	149	14	grade	grade	NOUN
aiua-13762	149	15	pca	pca	NOUN
aiua-13762	149	16	(	(	PUNCT
aiua-13762	149	17	gleason	gleason	PROPN
aiua-13762	149	18	score	score	VERB
aiua-13762	149	19	>	>	X
aiua-13762	149	20	7	7	NUM
aiua-13762	149	21	)	)	PUNCT
aiua-13762	149	22	compared	compare	VERB
aiua-13762	149	23	to	to	ADP
aiua-13762	149	24	non	non	NOUN
aiua-13762	149	25	-	-	NOUN
aiua-13762	149	26	carriers	carrier	NOUN
aiua-13762	149	27	(	(	PUNCT
aiua-13762	149	28	85	85	NUM
aiua-13762	149	29	%	%	NOUN
aiua-13762	149	30	vs.	vs.	ADP
aiua-13762	149	31	50	50	NUM
aiua-13762	149	32	%	%	NOUN
aiua-13762	149	33	,	,	PUNCT
aiua-13762	149	34	respectively	respectively	ADV
aiua-13762	149	35	;	;	PUNCT
aiua-13762	149	36	p	p	PROPN
aiua-13762	149	37	=	=	NOUN
aiua-13762	149	38	0.0002	0.0002	NUM
aiua-13762	149	39	)	)	PUNCT
aiua-13762	149	40	,	,	PUNCT
aiua-13762	149	41	while	while	SCONJ
aiua-13762	149	42	brca1	brca1	PROPN
aiua-13762	149	43	185delag	185delag	PROPN
aiua-13762	149	44	carriers	carrier	NOUN
aiua-13762	149	45	were	be	AUX
aiua-13762	149	46	evenly	evenly	ADV
aiua-13762	149	47	distributed	distribute	VERB
aiua-13762	149	48	between	between	ADP
aiua-13762	149	49	highand	highand	ADJ
aiua-13762	149	50	low	low	ADJ
aiua-13762	149	51	-	-	PUNCT
aiua-13762	149	52	grade	grade	NOUN
aiua-13762	149	53	disease	disease	NOUN
aiua-13762	149	54	(	(	PUNCT
aiua-13762	149	55	50	50	NUM
aiua-13762	149	56	%	%	NOUN
aiua-13762	149	57	vs.	vs.	ADP
aiua-13762	149	58	50	50	NUM
aiua-13762	149	59	%	%	NOUN
aiua-13762	149	60	)	)	PUNCT
aiua-13762	149	61	.	.	PUNCT
aiua-13762	150	1	both	both	DET
aiua-13762	150	2	brca1	brca1	PROPN
aiua-13762	150	3	185delag	185delag	PROPN
aiua-13762	150	4	and	and	CCONJ
aiua-13762	150	5	brca2	brca2	NOUN
aiua-13762	150	6	6174delt	6174delt	NUM
aiua-13762	150	7	carriers	carrier	NOUN
aiua-13762	150	8	had	have	VERB
aiua-13762	150	9	significantly	significantly	ADV
aiua-13762	150	10	higher	high	ADJ
aiua-13762	150	11	hazards	hazard	NOUN
aiua-13762	150	12	of	of	ADP
aiua-13762	150	13	biochemical	biochemical	ADJ
aiua-13762	150	14	recurrence	recurrence	NOUN
aiua-13762	150	15	(	(	PUNCT
aiua-13762	150	16	hazard	hazard	NOUN
aiua-13762	150	17	ratio	ratio	NOUN
aiua-13762	151	1	[	[	X
aiua-13762	151	2	hr	hr	X
aiua-13762	151	3	]	]	PUNCT
aiua-13762	151	4	for	for	ADP
aiua-13762	151	5	185delag	185delag	PROPN
aiua-13762	151	6	,	,	PUNCT
aiua-13762	151	7	4.32	4.32	NUM
aiua-13762	151	8	;	;	PUNCT
aiua-13762	151	9	95	95	NUM
aiua-13762	151	10	%	%	NOUN
aiua-13762	151	11	ci	ci	NOUN
aiua-13762	151	12	,	,	PUNCT
aiua-13762	151	13	1.31	1.31	NUM
aiua-13762	151	14	-	-	SYM
aiua-13762	151	15	13.62	13.62	NUM
aiua-13762	151	16	;	;	PUNCT
aiua-13762	151	17	hr	hr	NOUN
aiua-13762	151	18	for	for	ADP
aiua-13762	151	19	6174delt	6174delt	NUM
aiua-13762	151	20	,	,	PUNCT
aiua-13762	151	21	2.41	2.41	NUM
aiua-13762	151	22	;	;	PUNCT
aiua-13762	151	23	95	95	NUM
aiua-13762	151	24	%	%	NOUN
aiua-13762	151	25	ci	ci	NOUN
aiua-13762	151	26	,	,	PUNCT
aiua-13762	151	27	1.23	1.23	NUM
aiua-13762	151	28	-	-	SYM
aiua-13762	151	29	4.75	4.75	NUM
aiua-13762	151	30	)	)	PUNCT
aiua-13762	151	31	and	and	CCONJ
aiua-13762	151	32	prostate	prostate	NOUN
aiua-13762	151	33	cancer	cancer	NOUN
aiua-13762	151	34	death	death	NOUN
aiua-13762	151	35	(	(	PUNCT
aiua-13762	151	36	hr	hr	NOUN
aiua-13762	151	37	for	for	ADP
aiua-13762	151	38	185delag	185delag	PROPN
aiua-13762	151	39	,	,	PUNCT
aiua-13762	151	40	5.16	5.16	NUM
aiua-13762	151	41	;	;	PUNCT
aiua-13762	151	42	95	95	NUM
aiua-13762	151	43	%	%	NOUN
aiua-13762	151	44	ci	ci	NOUN
aiua-13762	151	45	,	,	PUNCT
aiua-13762	151	46	1.09	1.09	NUM
aiua-13762	151	47	-	-	SYM
aiua-13762	151	48	24.53	24.53	NUM
aiua-13762	151	49	;	;	PUNCT
aiua-13762	151	50	hr	hr	NOUN
aiua-13762	151	51	for	for	ADP
aiua-13762	151	52	6174delt	6174delt	NUM
aiua-13762	151	53	,	,	PUNCT
aiua-13762	151	54	5.48	5.48	NUM
aiua-13762	151	55	;	;	PUNCT
aiua-13762	151	56	95	95	NUM
aiua-13762	151	57	%	%	NOUN
aiua-13762	151	58	ci	ci	NOUN
aiua-13762	151	59	,	,	PUNCT
aiua-13762	151	60	2.03	2.03	NUM
aiua-13762	151	61	-	-	SYM
aiua-13762	151	62	14.79	14.79	NUM
aiua-13762	151	63	)	)	PUNCT
aiua-13762	151	64	compared	compare	VERB
aiua-13762	151	65	to	to	ADP
aiua-13762	151	66	non	non	NOUN
aiua-13762	151	67	-	-	NOUN
aiua-13762	151	68	carriers	carrier	NOUN
aiua-13762	151	69	.	.	PUNCT
aiua-13762	152	1	additionally	additionally	ADV
aiua-13762	152	2	,	,	PUNCT
aiua-13762	152	3	carriers	carrier	NOUN
aiua-13762	152	4	of	of	ADP
aiua-13762	152	5	brca2	brca2	NOUN
aiua-13762	152	6	6174delt	6174delt	NUM
aiua-13762	152	7	,	,	PUNCT
aiua-13762	152	8	but	but	CCONJ
aiua-13762	152	9	not	not	PART
aiua-13762	152	10	brca1	brca1	PROPN
aiua-13762	152	11	185delag	185delag	PROPN
aiua-13762	152	12	,	,	PUNCT
aiua-13762	152	13	exhibited	exhibit	VERB
aiua-13762	152	14	a	a	DET
aiua-13762	152	15	significantly	significantly	ADV
aiua-13762	152	16	higher	high	ADJ
aiua-13762	152	17	hazard	hazard	NOUN
aiua-13762	152	18	for	for	ADP
aiua-13762	152	19	castration	castration	NOUN
aiua-13762	152	20	-	-	PUNCT
aiua-13762	152	21	resistant	resistant	ADJ
aiua-13762	152	22	metastatic	metastatic	ADJ
aiua-13762	152	23	disease	disease	NOUN
aiua-13762	152	24	(	(	PUNCT
aiua-13762	152	25	hr,3.01	hr,3.01	NOUN
aiua-13762	152	26	;	;	PUNCT
aiua-13762	152	27	95	95	NUM
aiua-13762	152	28	%	%	NOUN
aiua-13762	152	29	ci	ci	NOUN
aiua-13762	152	30	,	,	PUNCT
aiua-13762	152	31	1.26	1.26	NUM
aiua-13762	152	32	-	-	NUM
aiua-13762	152	33	7.14	7.14	NUM
aiua-13762	152	34	)	)	PUNCT
aiua-13762	152	35	.	.	PUNCT
aiua-13762	153	1	in	in	ADP
aiua-13762	153	2	2009	2009	NUM
aiua-13762	153	3	,	,	PUNCT
aiua-13762	153	4	agalliu	agalliu	ADJ
aiua-13762	153	5	and	and	CCONJ
aiua-13762	153	6	colleagues	colleague	NOUN
aiua-13762	153	7	compared	compare	VERB
aiua-13762	153	8	979	979	NUM
aiua-13762	153	9	ashkenazi	ashkenazi	ADJ
aiua-13762	153	10	pca	pca	PROPN
aiua-13762	153	11	cases	case	NOUN
aiua-13762	153	12	with	with	ADP
aiua-13762	153	13	1251	1251	NUM
aiua-13762	153	14	healthy	healthy	ADJ
aiua-13762	153	15	aj	aj	PROPN
aiua-13762	153	16	controls	control	NOUN
aiua-13762	153	17	.	.	PUNCT
aiua-13762	154	1	the	the	DET
aiua-13762	154	2	odds	odd	NOUN
aiua-13762	154	3	of	of	ADP
aiua-13762	154	4	high	high	ADJ
aiua-13762	154	5	-	-	PUNCT
aiua-13762	154	6	grade	grade	NOUN
aiua-13762	154	7	pca	pca	NOUN
aiua-13762	154	8	(	(	PUNCT
aiua-13762	154	9	gleason	gleason	PROPN
aiua-13762	154	10	score	score	VERB
aiua-13762	154	11	>	>	X
aiua-13762	154	12	7	7	NUM
aiua-13762	154	13	)	)	PUNCT
aiua-13762	154	14	were	be	AUX
aiua-13762	154	15	significantly	significantly	ADV
aiua-13762	154	16	higher	high	ADJ
aiua-13762	154	17	in	in	ADP
aiua-13762	154	18	carriers	carrier	NOUN
aiua-13762	154	19	of	of	ADP
aiua-13762	154	20	both	both	DET
aiua-13762	154	21	brca1	brca1	PROPN
aiua-13762	154	22	185delag	185delag	PROPN
aiua-13762	154	23	(	(	PUNCT
aiua-13762	154	24	or	or	CCONJ
aiua-13762	154	25	,	,	PUNCT
aiua-13762	154	26	3.54	3.54	NUM
aiua-13762	154	27	;	;	PUNCT
aiua-13762	154	28	95	95	NUM
aiua-13762	154	29	%	%	NOUN
aiua-13762	154	30	ci	ci	NOUN
aiua-13762	154	31	,	,	PUNCT
aiua-13762	154	32	1.22	1.22	NUM
aiua-13762	154	33	-	-	SYM
aiua-13762	154	34	10.31	10.31	NUM
aiua-13762	154	35	)	)	PUNCT
aiua-13762	154	36	and	and	CCONJ
aiua-13762	154	37	brca2	brca2	NOUN
aiua-13762	155	1	6174delt	6174delt	NUM
aiua-13762	155	2	(	(	PUNCT
aiua-13762	155	3	or	or	CCONJ
aiua-13762	155	4	,	,	PUNCT
aiua-13762	155	5	3.18	3.18	NUM
aiua-13762	155	6	;	;	PUNCT
aiua-13762	155	7	95	95	NUM
aiua-13762	155	8	%	%	NOUN
aiua-13762	155	9	ci	ci	NOUN
aiua-13762	155	10	,	,	PUNCT
aiua-13762	155	11	1.37	1.37	NUM
aiua-13762	155	12	-	-	SYM
aiua-13762	155	13	7.34	7.34	NUM
aiua-13762	155	14	)	)	PUNCT
aiua-13762	155	15	compared	compare	VERB
aiua-13762	155	16	to	to	ADP
aiua-13762	155	17	non	non	ADJ
aiua-13762	155	18	-	-	ADJ
aiua-13762	155	19	carrier	carrier	ADJ
aiua-13762	155	20	patients	patient	NOUN
aiua-13762	155	21	.	.	PUNCT
aiua-13762	156	1	however	however	ADV
aiua-13762	156	2	,	,	PUNCT
aiua-13762	156	3	the	the	DET
aiua-13762	156	4	proportion	proportion	NOUN
aiua-13762	156	5	of	of	ADP
aiua-13762	156	6	mutation	mutation	NOUN
aiua-13762	156	7	carriers	carrier	NOUN
aiua-13762	156	8	in	in	ADP
aiua-13762	156	9	this	this	DET
aiua-13762	156	10	study	study	NOUN
aiua-13762	156	11	was	be	AUX
aiua-13762	156	12	lower	low	ADJ
aiua-13762	156	13	than	than	ADP
aiua-13762	156	14	that	that	PRON
aiua-13762	156	15	reported	report	VERB
aiua-13762	156	16	by	by	ADP
aiua-13762	156	17	gallagher	gallagher	PROPN
aiua-13762	156	18	et	et	PROPN
aiua-13762	156	19	al	al	PROPN
aiua-13762	156	20	.	.	PROPN
aiua-13762	157	1	(	(	PUNCT
aiua-13762	157	2	64	64	NUM
aiua-13762	157	3	)	)	PUNCT
aiua-13762	157	4	.	.	PUNCT
aiua-13762	158	1	additionally	additionally	ADV
aiua-13762	158	2	,	,	PUNCT
aiua-13762	158	3	significantly	significantly	ADV
aiua-13762	158	4	higher	high	ADJ
aiua-13762	158	5	odds	odd	NOUN
aiua-13762	158	6	ratios	ratio	NOUN
aiua-13762	158	7	for	for	ADP
aiua-13762	158	8	pca	pca	PROPN
aiua-13762	158	9	were	be	AUX
aiua-13762	158	10	observed	observe	VERB
aiua-13762	158	11	in	in	ADP
aiua-13762	158	12	patients	patient	NOUN
aiua-13762	158	13	of	of	ADP
aiua-13762	158	14	all	all	DET
aiua-13762	158	15	ages	age	NOUN
aiua-13762	158	16	carrying	carry	VERB
aiua-13762	158	17	185delag	185delag	PROPN
aiua-13762	158	18	or	or	CCONJ
aiua-13762	158	19	6174delt	6174delt	NUM
aiua-13762	158	20	brca	brca	PROPN
aiua-13762	158	21	mutations	mutation	NOUN
aiua-13762	158	22	(	(	PUNCT
aiua-13762	158	23	or	or	CCONJ
aiua-13762	158	24	,	,	PUNCT
aiua-13762	158	25	1.91	1.91	NUM
aiua-13762	158	26	;	;	PUNCT
aiua-13762	158	27	95	95	NUM
aiua-13762	158	28	%	%	NOUN
aiua-13762	158	29	ci	ci	NOUN
aiua-13762	158	30	,	,	PUNCT
aiua-13762	158	31	1.05	1.05	NUM
aiua-13762	158	32	-	-	SYM
aiua-13762	158	33	3.48	3.48	NUM
aiua-13762	158	34	)	)	PUNCT
aiua-13762	158	35	.	.	PUNCT
aiua-13762	159	1	high	high	ADJ
aiua-13762	159	2	and	and	CCONJ
aiua-13762	159	3	significant	significant	ADJ
aiua-13762	159	4	odds	odd	NOUN
aiua-13762	159	5	ratios	ratio	NOUN
aiua-13762	159	6	were	be	AUX
aiua-13762	159	7	also	also	ADV
aiua-13762	159	8	found	find	VERB
aiua-13762	159	9	for	for	ADP
aiua-13762	159	10	patients	patient	NOUN
aiua-13762	159	11	over	over	ADP
aiua-13762	159	12	65	65	NUM
aiua-13762	159	13	years	year	NOUN
aiua-13762	159	14	of	of	ADP
aiua-13762	159	15	age	age	NOUN
aiua-13762	159	16	carrying	carry	VERB
aiua-13762	159	17	the	the	DET
aiua-13762	159	18	185delag	185delag	PROPN
aiua-13762	159	19	mutation	mutation	NOUN
aiua-13762	159	20	(	(	PUNCT
aiua-13762	159	21	or	or	CCONJ
aiua-13762	159	22	,	,	PUNCT
aiua-13762	159	23	6.91	6.91	NUM
aiua-13762	159	24	;	;	PUNCT
aiua-13762	159	25	95	95	NUM
aiua-13762	159	26	%	%	NOUN
aiua-13762	159	27	ci	ci	NOUN
aiua-13762	159	28	,	,	PUNCT
aiua-13762	159	29	1.37	1.37	NUM
aiua-13762	159	30	-	-	SYM
aiua-13762	159	31	34.87	34.87	NUM
aiua-13762	159	32	)	)	PUNCT
aiua-13762	159	33	,	,	PUNCT
aiua-13762	159	34	or	or	CCONJ
aiua-13762	159	35	any	any	PRON
aiua-13762	159	36	of	of	ADP
aiua-13762	159	37	the	the	DET
aiua-13762	159	38	185delag	185delag	PROPN
aiua-13762	159	39	or	or	CCONJ
aiua-13762	159	40	6174delt	6174delt	NUM
aiua-13762	159	41	mutations	mutation	NOUN
aiua-13762	159	42	(	(	PUNCT
aiua-13762	159	43	or	or	CCONJ
aiua-13762	159	44	,	,	PUNCT
aiua-13762	159	45	3.69	3.69	NUM
aiua-13762	159	46	;	;	PUNCT
aiua-13762	159	47	95	95	NUM
aiua-13762	159	48	%	%	NOUN
aiua-13762	159	49	ci	ci	NOUN
aiua-13762	159	50	,	,	PUNCT
aiua-13762	159	51	1.47	1.47	NUM
aiua-13762	159	52	-	-	SYM
aiua-13762	159	53	9.29	9.29	NUM
aiua-13762	159	54	)	)	PUNCT
aiua-13762	159	55	.	.	PUNCT
aiua-13762	160	1	consistent	consistent	ADJ
aiua-13762	160	2	with	with	ADP
aiua-13762	160	3	these	these	DET
aiua-13762	160	4	observations	observation	NOUN
aiua-13762	160	5	,	,	PUNCT
aiua-13762	160	6	in	in	ADP
aiua-13762	160	7	a	a	DET
aiua-13762	160	8	cohort	cohort	NOUN
aiua-13762	160	9	of	of	ADP
aiua-13762	160	10	146	146	NUM
aiua-13762	160	11	ashkenazi	ashkenazi	ADJ
aiua-13762	160	12	men	man	NOUN
aiua-13762	160	13	from	from	ADP
aiua-13762	160	14	canada	canada	PROPN
aiua-13762	160	15	diagnosed	diagnose	VERB
aiua-13762	160	16	exclusively	exclusively	ADV
aiua-13762	160	17	with	with	ADP
aiua-13762	160	18	metastatic	metastatic	ADJ
aiua-13762	160	19	pca	pca	PROPN
aiua-13762	160	20	,	,	PUNCT
aiua-13762	160	21	hamel	hamel	PROPN
aiua-13762	160	22	and	and	CCONJ
aiua-13762	160	23	colleagues	colleague	NOUN
aiua-13762	160	24	identified	identify	VERB
aiua-13762	160	25	two	two	NUM
aiua-13762	160	26	carriers	carrier	NOUN
aiua-13762	160	27	of	of	ADP
aiua-13762	160	28	the	the	DET
aiua-13762	160	29	brca2	brca2	NOUN
aiua-13762	160	30	6174delt	6174delt	NUM
aiua-13762	160	31	mutation	mutation	NOUN
aiua-13762	160	32	(	(	PUNCT
aiua-13762	160	33	65	65	NUM
aiua-13762	160	34	)	)	PUNCT
aiua-13762	160	35	.	.	PUNCT
aiua-13762	161	1	however	however	ADV
aiua-13762	161	2	,	,	PUNCT
aiua-13762	161	3	this	this	PRON
aiua-13762	161	4	was	be	AUX
aiua-13762	161	5	a	a	DET
aiua-13762	161	6	single	single	ADJ
aiua-13762	161	7	-	-	PUNCT
aiua-13762	161	8	cohort	cohort	NOUN
aiua-13762	161	9	study	study	NOUN
aiua-13762	161	10	and	and	CCONJ
aiua-13762	161	11	the	the	DET
aiua-13762	161	12	authors	author	NOUN
aiua-13762	161	13	compared	compare	VERB
aiua-13762	161	14	their	their	PRON
aiua-13762	161	15	data	datum	NOUN
aiua-13762	161	16	with	with	ADP
aiua-13762	161	17	those	those	PRON
aiua-13762	161	18	of	of	ADP
aiua-13762	161	19	other	other	ADJ
aiua-13762	161	20	studies	study	NOUN
aiua-13762	161	21	to	to	PART
aiua-13762	161	22	attempt	attempt	VERB
aiua-13762	161	23	statistical	statistical	ADJ
aiua-13762	161	24	inference	inference	NOUN
aiua-13762	161	25	.	.	PUNCT
aiua-13762	162	1	at	at	ADP
aiua-13762	162	2	the	the	DET
aiua-13762	162	3	hadassah	hadassah	PROPN
aiua-13762	162	4	medical	medical	ADJ
aiua-13762	162	5	center	center	NOUN
aiua-13762	162	6	in	in	ADP
aiua-13762	162	7	jerusalem	jerusalem	PROPN
aiua-13762	162	8	,	,	PUNCT
aiua-13762	162	9	israel	israel	PROPN
aiua-13762	162	10	,	,	PUNCT
aiua-13762	162	11	hubert	hubert	PROPN
aiua-13762	162	12	et	et	PROPN
aiua-13762	162	13	al	al	PROPN
aiua-13762	162	14	.	.	PROPN
aiua-13762	162	15	compared	compare	VERB
aiua-13762	162	16	87	87	NUM
aiua-13762	162	17	aj	aj	PROPN
aiua-13762	162	18	men	man	NOUN
aiua-13762	162	19	with	with	ADP
aiua-13762	162	20	pca	pca	PROPN
aiua-13762	162	21	to	to	ADP
aiua-13762	162	22	87	87	NUM
aiua-13762	162	23	healthy	healthy	ADJ
aiua-13762	162	24	ashkenazi	ashkenazi	ADJ
aiua-13762	162	25	controls	control	NOUN
aiua-13762	162	26	.	.	PUNCT
aiua-13762	163	1	they	they	PRON
aiua-13762	163	2	identified	identify	VERB
aiua-13762	163	3	three	three	NUM
aiua-13762	163	4	mutation	mutation	NOUN
aiua-13762	163	5	carriers	carrier	NOUN
aiua-13762	163	6	in	in	ADP
aiua-13762	163	7	the	the	DET
aiua-13762	163	8	pca	pca	PROPN
aiua-13762	163	9	cohort	cohort	NOUN
aiua-13762	163	10	:	:	PUNCT
aiua-13762	163	11	two	two	NUM
aiua-13762	163	12	with	with	ADP
aiua-13762	163	13	brca1	brca1	PROPN
aiua-13762	163	14	185delag	185delag	PROPN
aiua-13762	163	15	and	and	CCONJ
aiua-13762	163	16	one	one	NUM
aiua-13762	163	17	with	with	ADP
aiua-13762	163	18	brca2	brca2	NOUN
aiua-13762	163	19	6174delt	6174delt	NUM
aiua-13762	163	20	,	,	PUNCT
aiua-13762	163	21	while	while	SCONJ
aiua-13762	163	22	three	three	NUM
aiua-13762	163	23	healthy	healthy	ADJ
aiua-13762	163	24	carriers	carrier	NOUN
aiua-13762	163	25	were	be	AUX
aiua-13762	163	26	found	find	VERB
aiua-13762	163	27	in	in	ADP
aiua-13762	163	28	the	the	DET
aiua-13762	163	29	control	control	NOUN
aiua-13762	163	30	group	group	NOUN
aiua-13762	163	31	.	.	PUNCT
aiua-13762	164	1	despite	despite	SCONJ
aiua-13762	164	2	the	the	DET
aiua-13762	164	3	small	small	ADJ
aiua-13762	164	4	sample	sample	NOUN
aiua-13762	164	5	size	size	NOUN
aiua-13762	164	6	,	,	PUNCT
aiua-13762	164	7	the	the	DET
aiua-13762	164	8	fact	fact	NOUN
aiua-13762	164	9	that	that	SCONJ
aiua-13762	164	10	all	all	DET
aiua-13762	164	11	three	three	NUM
aiua-13762	164	12	mutation	mutation	NOUN
aiua-13762	164	13	carrier	carrier	NOUN
aiua-13762	164	14	patients	patient	NOUN
aiua-13762	164	15	had	have	AUX
aiua-13762	164	16	been	be	AUX
aiua-13762	164	17	diagnosed	diagnose	VERB
aiua-13762	164	18	at	at	ADP
aiua-13762	164	19	stage	stage	NOUN
aiua-13762	164	20	b	b	PROPN
aiua-13762	164	21	with	with	ADP
aiua-13762	164	22	gleason	gleason	PROPN
aiua-13762	164	23	scores	score	NOUN
aiua-13762	164	24	of	of	ADP
aiua-13762	164	25	7	7	NUM
aiua-13762	164	26	,	,	PUNCT
aiua-13762	164	27	8	8	NUM
aiua-13762	164	28	,	,	PUNCT
aiua-13762	164	29	and	and	CCONJ
aiua-13762	164	30	>	>	SYM
aiua-13762	164	31	8	8	NUM
aiua-13762	164	32	-higher	-higher	NOUN
aiua-13762	164	33	than	than	ADP
aiua-13762	164	34	the	the	DET
aiua-13762	164	35	average	average	NOUN
aiua-13762	164	36	for	for	ADP
aiua-13762	164	37	noncarriers	noncarrier	NOUN
aiua-13762	164	38	at	at	ADP
aiua-13762	164	39	stage	stage	NOUN
aiua-13762	164	40	b	b	PROPN
aiua-13762	164	41	and	and	CCONJ
aiua-13762	164	42	similar	similar	ADJ
aiua-13762	164	43	to	to	ADP
aiua-13762	164	44	the	the	DET
aiua-13762	164	45	average	average	NOUN
aiua-13762	164	46	at	at	ADP
aiua-13762	164	47	stage	stage	NOUN
aiua-13762	164	48	dsupports	dsupport	NOUN
aiua-13762	164	49	the	the	DET
aiua-13762	164	50	findings	finding	NOUN
aiua-13762	164	51	of	of	ADP
aiua-13762	164	52	gallagher	gallagher	PROPN
aiua-13762	164	53	et	et	PROPN
aiua-13762	164	54	al	al	PROPN
aiua-13762	164	55	.	.	PROPN
aiua-13762	164	56	and	and	CCONJ
aiua-13762	164	57	agalliu	agalliu	VERB
aiua-13762	164	58	et	et	PROPN
aiua-13762	164	59	al	al	PROPN
aiua-13762	164	60	.	.	PROPN
aiua-13762	165	1	regarding	regard	VERB
aiua-13762	165	2	the	the	DET
aiua-13762	165	3	increased	increase	VERB
aiua-13762	165	4	likelihood	likelihood	NOUN
aiua-13762	165	5	of	of	ADP
aiua-13762	165	6	mutation	mutation	NOUN
aiua-13762	165	7	carriers	carrier	NOUN
aiua-13762	165	8	of	of	ADP
aiua-13762	165	9	being	be	AUX
aiua-13762	165	10	affected	affect	VERB
aiua-13762	165	11	by	by	ADP
aiua-13762	165	12	high	high	ADJ
aiua-13762	165	13	-	-	PUNCT
aiua-13762	165	14	grade	grade	NOUN
aiua-13762	165	15	pca	pca	NOUN
aiua-13762	165	16	(	(	PUNCT
aiua-13762	165	17	66	66	NUM
aiua-13762	165	18	)	)	PUNCT
aiua-13762	165	19	.	.	PUNCT
aiua-13762	166	1	kwon	kwon	AUX
aiua-13762	166	2	et	et	PROPN
aiua-13762	166	3	al	al	PROPN
aiua-13762	166	4	.	.	PROPN
aiua-13762	166	5	analyzed	analyze	VERB
aiua-13762	166	6	genetic	genetic	ADJ
aiua-13762	166	7	and	and	CCONJ
aiua-13762	166	8	clinical	clinical	ADJ
aiua-13762	166	9	data	datum	NOUN
aiua-13762	166	10	from	from	ADP
aiua-13762	166	11	a	a	DET
aiua-13762	166	12	cohort	cohort	NOUN
aiua-13762	166	13	of	of	ADP
aiua-13762	166	14	1351	1351	NUM
aiua-13762	166	15	men	man	NOUN
aiua-13762	166	16	of	of	ADP
aiua-13762	166	17	various	various	ADJ
aiua-13762	166	18	ethnicities	ethnicity	NOUN
aiua-13762	166	19	diagnosed	diagnose	VERB
aiua-13762	166	20	with	with	ADP
aiua-13762	166	21	pca	pca	PROPN
aiua-13762	166	22	,	,	PUNCT
aiua-13762	166	23	including	include	VERB
aiua-13762	166	24	150	150	NUM
aiua-13762	166	25	ashkenazi	ashkenazi	ADJ
aiua-13762	166	26	patients	patient	NOUN
aiua-13762	166	27	(	(	PUNCT
aiua-13762	166	28	11	11	NUM
aiua-13762	166	29	%	%	NOUN
aiua-13762	166	30	)	)	PUNCT
aiua-13762	166	31	.	.	PUNCT
aiua-13762	167	1	they	they	PRON
aiua-13762	167	2	found	find	VERB
aiua-13762	167	3	that	that	SCONJ
aiua-13762	167	4	ashkenazim	ashkenazim	PROPN
aiua-13762	167	5	were	be	AUX
aiua-13762	167	6	more	more	ADV
aiua-13762	167	7	likely	likely	ADJ
aiua-13762	167	8	than	than	SCONJ
aiua-13762	167	9	caucasian	caucasian	ADJ
aiua-13762	167	10	men	man	NOUN
aiua-13762	167	11	to	to	PART
aiua-13762	167	12	carry	carry	VERB
aiua-13762	167	13	pathogenic	pathogenic	ADJ
aiua-13762	167	14	mutations	mutation	NOUN
aiua-13762	167	15	in	in	ADP
aiua-13762	167	16	brca2	brca2	NOUN
aiua-13762	167	17	or	or	CCONJ
aiua-13762	167	18	chek2	chek2	NOUN
aiua-13762	167	19	(	(	PUNCT
aiua-13762	167	20	6.7	6.7	NUM
aiua-13762	167	21	%	%	NOUN
aiua-13762	167	22	vs.	vs.	ADP
aiua-13762	167	23	2.8	2.8	NUM
aiua-13762	167	24	%	%	NOUN
aiua-13762	167	25	,	,	PUNCT
aiua-13762	167	26	p	p	X
aiua-13762	167	27	=	=	NOUN
aiua-13762	167	28	0.01	0.01	NUM
aiua-13762	167	29	,	,	PUNCT
aiua-13762	167	30	and	and	CCONJ
aiua-13762	167	31	5.3	5.3	NUM
aiua-13762	167	32	%	%	NOUN
aiua-13762	167	33	vs.	vs.	ADP
aiua-13762	167	34	2.8	2.8	NUM
aiua-13762	167	35	%	%	NOUN
aiua-13762	167	36	,	,	PUNCT
aiua-13762	167	37	respectively	respectively	ADV
aiua-13762	167	38	)	)	PUNCT
aiua-13762	167	39	,	,	PUNCT
aiua-13762	167	40	while	while	SCONJ
aiua-13762	167	41	pathogenic	pathogenic	ADJ
aiua-13762	167	42	or	or	CCONJ
aiua-13762	167	43	likely	likely	ADV
aiua-13762	167	44	pathogenic	pathogenic	ADJ
aiua-13762	167	45	brca1	brca1	NOUN
aiua-13762	167	46	mutations	mutation	NOUN
aiua-13762	167	47	were	be	AUX
aiua-13762	167	48	similar	similar	ADJ
aiua-13762	167	49	in	in	ADP
aiua-13762	167	50	ashkenazi	ashkenazi	ADJ
aiua-13762	167	51	men	man	NOUN
aiua-13762	167	52	compared	compare	VERB
aiua-13762	167	53	to	to	ADP
aiua-13762	167	54	caucasians	caucasian	NOUN
aiua-13762	167	55	(	(	PUNCT
aiua-13762	167	56	0.7	0.7	NUM
aiua-13762	167	57	%	%	NOUN
aiua-13762	167	58	vs.	vs.	ADP
aiua-13762	167	59	0.8	0.8	NUM
aiua-13762	167	60	%	%	NOUN
aiua-13762	167	61	)	)	PUNCT
aiua-13762	167	62	.	.	PUNCT
aiua-13762	168	1	unexpectedly	unexpectedly	ADV
aiua-13762	168	2	,	,	PUNCT
aiua-13762	168	3	ashkenazi	ashkenazi	ADJ
aiua-13762	168	4	mutation	mutation	NOUN
aiua-13762	168	5	carriers	carrier	NOUN
aiua-13762	168	6	were	be	AUX
aiua-13762	168	7	diagnosed	diagnose	VERB
aiua-13762	168	8	at	at	ADP
aiua-13762	168	9	an	an	DET
aiua-13762	168	10	older	old	ADJ
aiua-13762	168	11	age	age	NOUN
aiua-13762	168	12	compared	compare	VERB
aiua-13762	168	13	to	to	ADP
aiua-13762	168	14	caucasians	caucasian	NOUN
aiua-13762	168	15	(	(	PUNCT
aiua-13762	168	16	66.6	66.6	NUM
aiua-13762	168	17	vs.	vs.	ADP
aiua-13762	168	18	60.5	60.5	NUM
aiua-13762	168	19	years	year	NOUN
aiua-13762	168	20	,	,	PUNCT
aiua-13762	168	21	p	p	X
aiua-13762	168	22	<	<	X
aiua-13762	168	23	0.01	0.01	NUM
aiua-13762	168	24	)	)	PUNCT
aiua-13762	168	25	(	(	PUNCT
aiua-13762	168	26	67	67	NUM
aiua-13762	168	27	)	)	PUNCT
aiua-13762	168	28	.	.	PUNCT
aiua-13762	169	1	the	the	DET
aiua-13762	169	2	significant	significant	ADJ
aiua-13762	169	3	findings	finding	NOUN
aiua-13762	169	4	summarized	summarize	VERB
aiua-13762	169	5	above	above	ADV
aiua-13762	169	6	could	could	AUX
aiua-13762	169	7	not	not	PART
aiua-13762	169	8	be	be	AUX
aiua-13762	169	9	replicated	replicate	VERB
aiua-13762	169	10	in	in	ADP
aiua-13762	169	11	studies	study	NOUN
aiua-13762	169	12	performed	perform	VERB
aiua-13762	169	13	on	on	ADP
aiua-13762	169	14	smaller	small	ADJ
aiua-13762	169	15	cohorts	cohort	NOUN
aiua-13762	169	16	of	of	ADP
aiua-13762	169	17	patients	patient	NOUN
aiua-13762	169	18	.	.	PUNCT
aiua-13762	170	1	for	for	ADP
aiua-13762	170	2	instance	instance	NOUN
aiua-13762	170	3	,	,	PUNCT
aiua-13762	170	4	lehrer	lehrer	NOUN
aiua-13762	170	5	and	and	CCONJ
aiua-13762	170	6	colleagues	colleague	NOUN
aiua-13762	170	7	did	do	AUX
aiua-13762	170	8	not	not	PART
aiua-13762	170	9	detect	detect	VERB
aiua-13762	170	10	any	any	DET
aiua-13762	170	11	carriers	carrier	NOUN
aiua-13762	170	12	of	of	ADP
aiua-13762	170	13	brca1	brca1	PROPN
aiua-13762	170	14	or	or	CCONJ
aiua-13762	170	15	brca2	brca2	NOUN
aiua-13762	170	16	founder	founder	NOUN
aiua-13762	170	17	mutations	mutation	NOUN
aiua-13762	170	18	in	in	ADP
aiua-13762	170	19	a	a	DET
aiua-13762	170	20	cohort	cohort	NOUN
aiua-13762	170	21	of	of	ADP
aiua-13762	170	22	60	60	NUM
aiua-13762	170	23	ashkenazi	ashkenazi	ADJ
aiua-13762	170	24	pca	pca	NOUN
aiua-13762	170	25	patients	patient	NOUN
aiua-13762	170	26	(	(	PUNCT
aiua-13762	170	27	68	68	NUM
aiua-13762	170	28	)	)	PUNCT
aiua-13762	170	29	,	,	PUNCT
aiua-13762	170	30	and	and	CCONJ
aiua-13762	170	31	wilkens	wilkens	PROPN
aiua-13762	170	32	et	et	PROPN
aiua-13762	170	33	al	al	PROPN
aiua-13762	170	34	.	.	PROPN
aiua-13762	170	35	identified	identify	VERB
aiua-13762	170	36	a	a	DET
aiua-13762	170	37	single	single	ADJ
aiua-13762	170	38	healthy	healthy	ADJ
aiua-13762	170	39	carrier	carrier	NOUN
aiua-13762	170	40	of	of	ADP
aiua-13762	170	41	brca2	brca2	PROPN
aiua-13762	171	1	6174delt	6174delt	NUM
aiua-13762	171	2	in	in	ADP
aiua-13762	171	3	a	a	DET
aiua-13762	171	4	study	study	NOUN
aiua-13762	171	5	of	of	ADP
aiua-13762	171	6	18	18	NUM
aiua-13762	171	7	aj	aj	PROPN
aiua-13762	171	8	families	family	NOUN
aiua-13762	171	9	with	with	ADP
aiua-13762	171	10	at	at	ADV
aiua-13762	171	11	least	least	ADV
aiua-13762	171	12	three	three	NUM
aiua-13762	171	13	first	first	ADJ
aiua-13762	171	14	-	-	PUNCT
aiua-13762	171	15	degree	degree	NOUN
aiua-13762	171	16	relatives	relative	NOUN
aiua-13762	171	17	affected	affect	VERB
aiua-13762	171	18	by	by	ADP
aiua-13762	171	19	pca	pca	PROPN
aiua-13762	171	20	(	(	PUNCT
aiua-13762	171	21	69	69	NUM
aiua-13762	171	22	)	)	PUNCT
aiua-13762	171	23	.	.	PUNCT
aiua-13762	172	1	other	other	ADJ
aiua-13762	172	2	studies	study	NOUN
aiua-13762	172	3	,	,	PUNCT
aiua-13762	172	4	such	such	ADJ
aiua-13762	172	5	as	as	ADP
aiua-13762	172	6	the	the	DET
aiua-13762	172	7	1995	1995	NUM
aiua-13762	172	8	study	study	NOUN
aiua-13762	172	9	by	by	ADP
aiua-13762	172	10	friedman	friedman	PROPN
aiua-13762	172	11	et	et	PROPN
aiua-13762	172	12	al	al	PROPN
aiua-13762	172	13	.	.	PROPN
aiua-13762	172	14	,	,	PUNCT
aiua-13762	172	15	which	which	PRON
aiua-13762	172	16	examined	examine	VERB
aiua-13762	172	17	37	37	NUM
aiua-13762	172	18	aj	aj	PROPN
aiua-13762	172	19	families	family	NOUN
aiua-13762	172	20	with	with	ADP
aiua-13762	172	21	a	a	DET
aiua-13762	172	22	high	high	ADJ
aiua-13762	172	23	prevalence	prevalence	NOUN
aiua-13762	172	24	of	of	ADP
aiua-13762	172	25	familial	familial	ADJ
aiua-13762	172	26	breast	breast	NOUN
aiua-13762	172	27	cancer	cancer	NOUN
aiua-13762	172	28	,	,	PUNCT
aiua-13762	172	29	found	find	VERB
aiua-13762	172	30	no	no	DET
aiua-13762	172	31	cases	case	NOUN
aiua-13762	172	32	of	of	ADP
aiua-13762	172	33	prostate	prostate	NOUN
aiua-13762	172	34	cancer	cancer	NOUN
aiua-13762	172	35	among	among	ADP
aiua-13762	172	36	deletion	deletion	NOUN
aiua-13762	172	37	carriers	carrier	NOUN
aiua-13762	172	38	(	(	PUNCT
aiua-13762	172	39	70	70	NUM
aiua-13762	172	40	)	)	PUNCT
aiua-13762	172	41	.	.	PUNCT
aiua-13762	173	1	similarly	similarly	ADV
aiua-13762	173	2	,	,	PUNCT
aiua-13762	173	3	nastiuk	nastiuk	NOUN
aiua-13762	173	4	et	et	PROPN
aiua-13762	173	5	al	al	PROPN
aiua-13762	173	6	.	.	PROPN
aiua-13762	173	7	found	find	VERB
aiua-13762	173	8	that	that	SCONJ
aiua-13762	173	9	brca1	brca1	NOUN
aiua-13762	173	10	-	-	PUNCT
aiua-13762	173	11	185delag	185delag	PROPN
aiua-13762	173	12	and	and	CCONJ
aiua-13762	173	13	brca2	brca2	PROPN
aiua-13762	173	14	-	-	PUNCT
aiua-13762	173	15	6174delt	6174delt	PROPN
aiua-13762	173	16	deletions	deletion	NOUN
aiua-13762	173	17	were	be	AUX
aiua-13762	173	18	present	present	ADJ
aiua-13762	173	19	in	in	ADP
aiua-13762	173	20	only	only	ADV
aiua-13762	173	21	1	1	NUM
aiua-13762	173	22	and	and	CCONJ
aiua-13762	173	23	2	2	NUM
aiua-13762	173	24	patients	patient	NOUN
aiua-13762	173	25	,	,	PUNCT
aiua-13762	173	26	respectively	respectively	ADV
aiua-13762	173	27	,	,	PUNCT
aiua-13762	173	28	out	out	ADP
aiua-13762	173	29	of	of	ADP
aiua-13762	173	30	83	83	NUM
aiua-13762	173	31	pca	pca	NOUN
aiua-13762	173	32	cases	case	NOUN
aiua-13762	173	33	.	.	PUNCT
aiua-13762	174	1	the	the	DET
aiua-13762	174	2	authors	author	NOUN
aiua-13762	174	3	concluded	conclude	VERB
aiua-13762	174	4	that	that	SCONJ
aiua-13762	174	5	the	the	DET
aiua-13762	174	6	study	study	NOUN
aiua-13762	174	7	was	be	AUX
aiua-13762	174	8	only	only	ADV
aiua-13762	174	9	powered	power	VERB
aiua-13762	174	10	to	to	PART
aiua-13762	174	11	detect	detect	VERB
aiua-13762	174	12	a	a	DET
aiua-13762	174	13	4	4	NUM
aiua-13762	174	14	-	-	SYM
aiua-13762	174	15	5	5	NUM
aiua-13762	174	16	-	-	ADJ
aiua-13762	174	17	fold	fold	ADJ
aiua-13762	174	18	increase	increase	NOUN
aiua-13762	174	19	in	in	ADP
aiua-13762	174	20	prostate	prostate	NOUN
aiua-13762	174	21	cancer	cancer	NOUN
aiua-13762	174	22	risk	risk	NOUN
aiua-13762	174	23	associated	associate	VERB
aiua-13762	174	24	with	with	ADP
aiua-13762	174	25	these	these	DET
aiua-13762	174	26	mutations	mutation	NOUN
aiua-13762	174	27	and	and	CCONJ
aiua-13762	174	28	recommended	recommend	VERB
aiua-13762	174	29	larger	large	ADJ
aiua-13762	174	30	studies	study	NOUN
aiua-13762	174	31	to	to	PART
aiua-13762	174	32	investigate	investigate	VERB
aiua-13762	174	33	smaller	small	ADJ
aiua-13762	174	34	but	but	CCONJ
aiua-13762	174	35	statistically	statistically	ADV
aiua-13762	174	36	significant	significant	ADJ
aiua-13762	174	37	increases	increase	NOUN
aiua-13762	174	38	in	in	ADP
aiua-13762	174	39	relative	relative	ADJ
aiua-13762	174	40	risk	risk	NOUN
aiua-13762	174	41	(	(	PUNCT
aiua-13762	174	42	71	71	NUM
aiua-13762	174	43	)	)	PUNCT
aiua-13762	174	44	.	.	PUNCT
aiua-13762	175	1	in	in	ADP
aiua-13762	175	2	conclusion	conclusion	NOUN
aiua-13762	175	3	,	,	PUNCT
aiua-13762	175	4	ensuring	ensure	VERB
aiua-13762	175	5	adequate	adequate	ADJ
aiua-13762	175	6	statistical	statistical	ADJ
aiua-13762	175	7	power	power	NOUN
aiua-13762	175	8	is	be	AUX
aiua-13762	175	9	essential	essential	ADJ
aiua-13762	175	10	in	in	ADP
aiua-13762	175	11	clinical	clinical	ADJ
aiua-13762	175	12	studies	study	NOUN
aiua-13762	175	13	to	to	PART
aiua-13762	175	14	reliably	reliably	ADV
aiua-13762	175	15	detect	detect	VERB
aiua-13762	175	16	true	true	ADJ
aiua-13762	175	17	associations	association	NOUN
aiua-13762	175	18	between	between	ADP
aiua-13762	175	19	genetic	genetic	ADJ
aiua-13762	175	20	variants	variant	NOUN
aiua-13762	175	21	and	and	CCONJ
aiua-13762	175	22	cancer	cancer	NOUN
aiua-13762	175	23	outcomes	outcome	NOUN
aiua-13762	175	24	,	,	PUNCT
aiua-13762	175	25	minimizing	minimize	VERB
aiua-13762	175	26	the	the	DET
aiua-13762	175	27	risk	risk	NOUN
aiua-13762	175	28	of	of	ADP
aiua-13762	175	29	false	false	ADJ
aiua-13762	175	30	negatives	negative	NOUN
aiua-13762	175	31	and	and	CCONJ
aiua-13762	175	32	ensuring	ensure	VERB
aiua-13762	175	33	that	that	SCONJ
aiua-13762	175	34	observed	observed	ADJ
aiua-13762	175	35	results	result	NOUN
aiua-13762	175	36	reflect	reflect	VERB
aiua-13762	175	37	genuine	genuine	ADJ
aiua-13762	175	38	associations	association	NOUN
aiua-13762	175	39	rather	rather	ADV
aiua-13762	175	40	than	than	ADP
aiua-13762	175	41	random	random	ADJ
aiua-13762	175	42	variation	variation	NOUN
aiua-13762	175	43	.	.	PUNCT
aiua-13762	176	1	meta	meta	ADJ
aiua-13762	176	2	-	-	PUNCT
aiua-13762	176	3	analyses	analysis	NOUN
aiua-13762	176	4	as	as	SCONJ
aiua-13762	176	5	shown	show	VERB
aiua-13762	176	6	in	in	ADP
aiua-13762	176	7	the	the	DET
aiua-13762	176	8	preceding	precede	VERB
aiua-13762	176	9	section	section	NOUN
aiua-13762	176	10	,	,	PUNCT
aiua-13762	176	11	studies	study	NOUN
aiua-13762	176	12	conducted	conduct	VERB
aiua-13762	176	13	on	on	ADP
aiua-13762	176	14	small	small	ADJ
aiua-13762	176	15	cohorts	cohort	NOUN
aiua-13762	176	16	of	of	ADP
aiua-13762	176	17	patients	patient	NOUN
aiua-13762	176	18	have	have	AUX
aiua-13762	176	19	failed	fail	VERB
aiua-13762	176	20	to	to	PART
aiua-13762	176	21	provide	provide	VERB
aiua-13762	176	22	conclusive	conclusive	ADJ
aiua-13762	176	23	evidence	evidence	NOUN
aiua-13762	176	24	regarding	regard	VERB
aiua-13762	176	25	the	the	DET
aiua-13762	176	26	risk	risk	NOUN
aiua-13762	176	27	and	and	CCONJ
aiua-13762	176	28	frequency	frequency	NOUN
aiua-13762	176	29	of	of	ADP
aiua-13762	176	30	prostate	prostate	NOUN
aiua-13762	176	31	pca	pca	PROPN
aiua-13762	176	32	in	in	ADP
aiua-13762	176	33	ashkenazi	ashkenazi	ADJ
aiua-13762	176	34	carriers	carrier	NOUN
aiua-13762	176	35	of	of	ADP
aiua-13762	176	36	brca1	brca1	PROPN
aiua-13762	176	37	or	or	CCONJ
aiua-13762	176	38	brca2	brca2	NOUN
aiua-13762	176	39	mutations	mutation	NOUN
aiua-13762	176	40	.	.	PUNCT
aiua-13762	177	1	in	in	ADP
aiua-13762	177	2	such	such	ADJ
aiua-13762	177	3	cases	case	NOUN
aiua-13762	177	4	,	,	PUNCT
aiua-13762	177	5	meta	meta	X
aiua-13762	177	6	-	-	PUNCT
aiua-13762	177	7	analyses	analysis	NOUN
aiua-13762	177	8	,	,	PUNCT
aiua-13762	177	9	which	which	PRON
aiua-13762	177	10	combine	combine	VERB
aiua-13762	177	11	data	datum	NOUN
aiua-13762	177	12	from	from	ADP
aiua-13762	177	13	smaller	small	ADJ
aiua-13762	177	14	studies	study	NOUN
aiua-13762	177	15	with	with	ADP
aiua-13762	177	16	those	those	PRON
aiua-13762	177	17	that	that	PRON
aiua-13762	177	18	have	have	VERB
aiua-13762	177	19	sufficient	sufficient	ADJ
aiua-13762	177	20	statistical	statistical	ADJ
aiua-13762	177	21	power	power	NOUN
aiua-13762	177	22	,	,	PUNCT
aiua-13762	177	23	offer	offer	VERB
aiua-13762	177	24	a	a	DET
aiua-13762	177	25	more	more	ADV
aiua-13762	177	26	robust	robust	ADJ
aiua-13762	177	27	understanding	understanding	NOUN
aiua-13762	177	28	of	of	ADP
aiua-13762	177	29	statistical	statistical	ADJ
aiua-13762	177	30	trends	trend	NOUN
aiua-13762	177	31	and	and	CCONJ
aiua-13762	177	32	provide	provide	VERB
aiua-13762	177	33	clinically	clinically	ADV
aiua-13762	177	34	relevant	relevant	ADJ
aiua-13762	177	35	insights	insight	NOUN
aiua-13762	177	36	.	.	PUNCT
aiua-13762	178	1	several	several	ADJ
aiua-13762	178	2	meta	meta	NOUN
aiua-13762	178	3	-	-	PUNCT
aiua-13762	178	4	analyses	analysis	NOUN
aiua-13762	178	5	have	have	AUX
aiua-13762	178	6	examined	examine	VERB
aiua-13762	178	7	the	the	DET
aiua-13762	178	8	association	association	NOUN
aiua-13762	178	9	between	between	ADP
aiua-13762	178	10	germline	germline	NOUN
aiua-13762	178	11	founder	founder	NOUN
aiua-13762	178	12	mutations	mutation	NOUN
aiua-13762	178	13	–	–	PUNCT
aiua-13762	178	14	including	include	VERB
aiua-13762	178	15	185delag	185delag	PROPN
aiua-13762	178	16	or	or	CCONJ
aiua-13762	178	17	5382insc	5382insc	PROPN
aiua-13762	178	18	in	in	ADP
aiua-13762	178	19	brca1	brca1	PROPN
aiua-13762	178	20	,	,	PUNCT
aiua-13762	178	21	and	and	CCONJ
aiua-13762	178	22	6174delt	6174delt	NUM
aiua-13762	178	23	in	in	ADP
aiua-13762	178	24	brca2	brca2	NOUN
aiua-13762	178	25	–	–	PUNCT
aiua-13762	178	26	and	and	CCONJ
aiua-13762	178	27	pca	pca	NOUN
aiua-13762	178	28	risk	risk	NOUN
aiua-13762	178	29	in	in	ADP
aiua-13762	178	30	aj	aj	PROPN
aiua-13762	178	31	.	.	PUNCT
aiua-13762	179	1	a	a	DET
aiua-13762	179	2	2019	2019	NUM
aiua-13762	179	3	study	study	NOUN
aiua-13762	179	4	by	by	ADP
aiua-13762	179	5	oh	oh	INTJ
aiua-13762	179	6	et	et	PROPN
aiua-13762	179	7	al	al	PROPN
aiua-13762	179	8	.	.	PROPN
aiua-13762	179	9	found	find	VERB
aiua-13762	179	10	that	that	SCONJ
aiua-13762	179	11	the	the	DET
aiua-13762	179	12	odds	odd	NOUN
aiua-13762	179	13	ratio	ratio	NOUN
aiua-13762	179	14	for	for	ADP
aiua-13762	179	15	pca	pca	NOUN
aiua-13762	179	16	in	in	ADP
aiua-13762	179	17	carriers	carrier	NOUN
aiua-13762	179	18	of	of	ADP
aiua-13762	179	19	brca1	brca1	PROPN
aiua-13762	179	20	and/or	and/or	CCONJ
aiua-13762	179	21	brca2	brca2	NOUN
aiua-13762	179	22	mutations	mutation	NOUN
aiua-13762	179	23	across	across	ADP
aiua-13762	179	24	all	all	DET
aiua-13762	179	25	populations	population	NOUN
aiua-13762	179	26	(	(	PUNCT
aiua-13762	179	27	both	both	CCONJ
aiua-13762	179	28	jewish	jewish	ADJ
aiua-13762	179	29	and	and	CCONJ
aiua-13762	179	30	non	non	ADJ
aiua-13762	179	31	-	-	ADJ
aiua-13762	179	32	jewish	jewish	ADJ
aiua-13762	179	33	)	)	PUNCT
aiua-13762	179	34	was	be	AUX
aiua-13762	179	35	1.90	1.90	NUM
aiua-13762	179	36	(	(	PUNCT
aiua-13762	179	37	95	95	NUM
aiua-13762	179	38	%	%	NOUN
aiua-13762	179	39	ci	ci	NOUN
aiua-13762	179	40	,	,	PUNCT
aiua-13762	179	41	1.58	1.58	NUM
aiua-13762	179	42	-	-	SYM
aiua-13762	179	43	2.29	2.29	NUM
aiua-13762	179	44	)	)	PUNCT
aiua-13762	179	45	.	.	PUNCT
aiua-13762	180	1	in	in	ADP
aiua-13762	180	2	an	an	DET
aiua-13762	180	3	ashkenazi	ashkenazi	ADJ
aiua-13762	180	4	subgroup	subgroup	NOUN
aiua-13762	180	5	,	,	PUNCT
aiua-13762	180	6	the	the	DET
aiua-13762	180	7	unadjusted	unadjusted	ADJ
aiua-13762	180	8	event	event	NOUN
aiua-13762	180	9	rate	rate	NOUN
aiua-13762	180	10	(	(	PUNCT
aiua-13762	180	11	er	er	INTJ
aiua-13762	180	12	)	)	PUNCT
aiua-13762	180	13	for	for	ADP
aiua-13762	180	14	pca	pca	PROPN
aiua-13762	180	15	among	among	ADP
aiua-13762	180	16	carriers	carrier	NOUN
aiua-13762	180	17	of	of	ADP
aiua-13762	180	18	any	any	DET
aiua-13762	180	19	brca	brca	PROPN
aiua-13762	180	20	founder	founder	NOUN
aiua-13762	180	21	mutation	mutation	NOUN
aiua-13762	180	22	was	be	AUX
aiua-13762	180	23	1.7	1.7	NUM
aiua-13762	180	24	%	%	NOUN
aiua-13762	180	25	(	(	PUNCT
aiua-13762	180	26	95	95	NUM
aiua-13762	180	27	%	%	NOUN
aiua-13762	180	28	ci	ci	NOUN
aiua-13762	180	29	,	,	PUNCT
aiua-13762	180	30	1.5	1.5	NUM
aiua-13762	180	31	-	-	SYM
aiua-13762	180	32	2.1	2.1	NUM
aiua-13762	180	33	)	)	PUNCT
aiua-13762	180	34	,	,	PUNCT
aiua-13762	180	35	with	with	ADP
aiua-13762	180	36	specific	specific	ADJ
aiua-13762	180	37	event	event	NOUN
aiua-13762	180	38	rates	rate	NOUN
aiua-13762	180	39	of	of	ADP
aiua-13762	180	40	1.4	1.4	NUM
aiua-13762	180	41	%	%	NOUN
aiua-13762	180	42	for	for	ADP
aiua-13762	180	43	brca1	brca1	NOUN
aiua-13762	180	44	and	and	CCONJ
aiua-13762	180	45	2.1	2.1	NUM
aiua-13762	180	46	%	%	NOUN
aiua-13762	180	47	for	for	ADP
aiua-13762	180	48	brca2	brca2	NOUN
aiua-13762	180	49	founder	founder	NOUN
aiua-13762	180	50	mutations	mutation	NOUN
aiua-13762	180	51	(	(	PUNCT
aiua-13762	180	52	95	95	NUM
aiua-13762	180	53	%	%	NOUN
aiua-13762	180	54	ci	ci	NOUN
aiua-13762	180	55	,	,	PUNCT
aiua-13762	180	56	1.0	1.0	NUM
aiua-13762	180	57	-	-	SYM
aiua-13762	180	58	1.8	1.8	NUM
aiua-13762	180	59	and	and	CCONJ
aiua-13762	180	60	1.6	1.6	NUM
aiua-13762	180	61	-	-	SYM
aiua-13762	180	62	2.6	2.6	NUM
aiua-13762	180	63	,	,	PUNCT
aiua-13762	180	64	respectively	respectively	ADV
aiua-13762	180	65	)	)	PUNCT
aiua-13762	180	66	(	(	PUNCT
aiua-13762	180	67	72	72	NUM
aiua-13762	180	68	)	)	PUNCT
aiua-13762	180	69	.	.	PUNCT
aiua-13762	181	1	a	a	DET
aiua-13762	181	2	subsequent	subsequent	ADJ
aiua-13762	181	3	meta	meta	ADJ
aiua-13762	181	4	-	-	PUNCT
aiua-13762	181	5	analysis	analysis	NOUN
aiua-13762	181	6	by	by	ADP
aiua-13762	181	7	nyberg	nyberg	PROPN
aiua-13762	181	8	et	et	PROPN
aiua-13762	181	9	al	al	PROPN
aiua-13762	181	10	.	.	PROPN
aiua-13762	181	11	differed	differ	VERB
aiua-13762	181	12	from	from	ADP
aiua-13762	181	13	the	the	DET
aiua-13762	181	14	oh	oh	NUM
aiua-13762	181	15	study	study	NOUN
aiua-13762	181	16	,	,	PUNCT
aiua-13762	181	17	as	as	SCONJ
aiua-13762	181	18	it	it	PRON
aiua-13762	181	19	excluded	exclude	VERB
aiua-13762	181	20	the	the	DET
aiua-13762	181	21	2019	2019	NUM
aiua-13762	181	22	case	case	NOUN
aiua-13762	181	23	series	series	NOUN
aiua-13762	181	24	by	by	ADP
aiua-13762	181	25	nastiuk	nastiuk	NOUN
aiua-13762	181	26	archivio	archivio	PROPN
aiua-13762	181	27	italiano	italiano	X
aiua-13762	181	28	di	di	X
aiua-13762	181	29	urologia	urologia	PROPN
aiua-13762	181	30	e	e	PROPN
aiua-13762	181	31	andrologia	andrologia	NOUN
aiua-13762	181	32	2025	2025	NUM
aiua-13762	181	33	;	;	PUNCT
aiua-13762	181	34	97(2):13762	97(2):13762	NUM
aiua-13762	181	35	g.	g.	PROPN
aiua-13762	181	36	perletti	perletti	PROPN
aiua-13762	181	37	,	,	PUNCT
aiua-13762	181	38	d.	d.	PROPN
aiua-13762	181	39	cohen	cohen	PROPN
aiua-13762	181	40	hattab	hattab	PROPN
aiua-13762	181	41	,	,	PUNCT
aiua-13762	181	42	s.	s.	PROPN
aiua-13762	181	43	dellapergola	dellapergola	PROPN
aiua-13762	181	44	,	,	PUNCT
aiua-13762	181	45	et	et	PROPN
aiua-13762	181	46	al	al	PROPN
aiua-13762	181	47	.	.	PROPN
aiua-13762	181	48	6	6	NUM
aiua-13762	181	49	et	et	NOUN
aiua-13762	181	50	al	al	PROPN
aiua-13762	181	51	.	.	PUNCT
aiua-13762	182	1	(	(	PUNCT
aiua-13762	182	2	71	71	NUM
aiua-13762	182	3	)	)	PUNCT
aiua-13762	182	4	.	.	PUNCT
aiua-13762	183	1	in	in	ADP
aiua-13762	183	2	men	man	NOUN
aiua-13762	183	3	of	of	ADP
aiua-13762	183	4	ashkenazi	ashkenazi	ADJ
aiua-13762	183	5	jewish	jewish	ADJ
aiua-13762	183	6	ancestry	ancestry	NOUN
aiua-13762	183	7	,	,	PUNCT
aiua-13762	183	8	the	the	DET
aiua-13762	183	9	risk	risk	NOUN
aiua-13762	183	10	ratio	ratio	NOUN
aiua-13762	183	11	(	(	PUNCT
aiua-13762	183	12	rr	rr	NOUN
aiua-13762	183	13	)	)	PUNCT
aiua-13762	183	14	for	for	ADP
aiua-13762	183	15	pca	pca	PROPN
aiua-13762	183	16	was	be	AUX
aiua-13762	183	17	statistically	statistically	ADV
aiua-13762	183	18	non	non	ADJ
aiua-13762	183	19	-	-	ADJ
aiua-13762	183	20	significant	significant	ADJ
aiua-13762	183	21	for	for	ADP
aiua-13762	183	22	brca1	brca1	PROPN
aiua-13762	183	23	founder	founder	NOUN
aiua-13762	183	24	mutation	mutation	NOUN
aiua-13762	183	25	carriers	carrier	NOUN
aiua-13762	183	26	(	(	PUNCT
aiua-13762	183	27	rr	rr	NOUN
aiua-13762	183	28	,	,	PUNCT
aiua-13762	183	29	1.12	1.12	NUM
aiua-13762	183	30	;	;	PUNCT
aiua-13762	183	31	95	95	NUM
aiua-13762	183	32	%	%	NOUN
aiua-13762	183	33	ci	ci	NOUN
aiua-13762	183	34	,	,	PUNCT
aiua-13762	183	35	0.552.31	0.552.31	PROPN
aiua-13762	183	36	)	)	PUNCT
aiua-13762	183	37	,	,	PUNCT
aiua-13762	183	38	while	while	SCONJ
aiua-13762	183	39	the	the	DET
aiua-13762	183	40	risk	risk	NOUN
aiua-13762	183	41	in	in	ADP
aiua-13762	183	42	carriers	carrier	NOUN
aiua-13762	183	43	of	of	ADP
aiua-13762	183	44	the	the	DET
aiua-13762	183	45	6174delt	6174delt	PROPN
aiua-13762	183	46	mutation	mutation	NOUN
aiua-13762	183	47	in	in	ADP
aiua-13762	183	48	brca2	brca2	PROPN
aiua-13762	183	49	was	be	AUX
aiua-13762	183	50	twofold	twofold	ADV
aiua-13762	183	51	and	and	CCONJ
aiua-13762	183	52	statistically	statistically	ADV
aiua-13762	183	53	significant	significant	ADJ
aiua-13762	183	54	(	(	PUNCT
aiua-13762	183	55	rr	rr	NOUN
aiua-13762	183	56	,	,	PUNCT
aiua-13762	183	57	2.08	2.08	NUM
aiua-13762	183	58	;	;	PUNCT
aiua-13762	183	59	95	95	NUM
aiua-13762	183	60	%	%	NOUN
aiua-13762	183	61	ci	ci	NOUN
aiua-13762	183	62	,	,	PUNCT
aiua-13762	183	63	1.38	1.38	NUM
aiua-13762	183	64	-	-	SYM
aiua-13762	183	65	3.12	3.12	NUM
aiua-13762	183	66	)	)	PUNCT
aiua-13762	183	67	(	(	PUNCT
aiua-13762	183	68	73	73	NUM
aiua-13762	183	69	)	)	PUNCT
aiua-13762	183	70	.	.	PUNCT
aiua-13762	184	1	risk	risk	NOUN
aiua-13762	184	2	ratios	ratio	NOUN
aiua-13762	184	3	for	for	ADP
aiua-13762	184	4	aj	aj	PROPN
aiua-13762	184	5	were	be	AUX
aiua-13762	184	6	consistently	consistently	ADV
aiua-13762	184	7	lower	low	ADJ
aiua-13762	184	8	compared	compare	VERB
aiua-13762	184	9	to	to	ADP
aiua-13762	184	10	non	non	ADJ
aiua-13762	184	11	-	-	ADJ
aiua-13762	184	12	ashkenazi	ashkenazi	ADJ
aiua-13762	184	13	men	man	NOUN
aiua-13762	184	14	of	of	ADP
aiua-13762	184	15	european	european	PROPN
aiua-13762	184	16	ancestry	ancestry	PROPN
aiua-13762	184	17	(	(	PUNCT
aiua-13762	184	18	e.g.	e.g.	ADV
aiua-13762	184	19	,	,	PUNCT
aiua-13762	184	20	rr	rr	VERB
aiua-13762	184	21	for	for	ADP
aiua-13762	184	22	brca2	brca2	PROPN
aiua-13762	184	23	6174delt	6174delt	NUM
aiua-13762	184	24	in	in	ADP
aiua-13762	184	25	europeans	europeans	PROPN
aiua-13762	184	26	:	:	PUNCT
aiua-13762	184	27	4.07	4.07	NUM
aiua-13762	184	28	;	;	PUNCT
aiua-13762	184	29	95	95	NUM
aiua-13762	184	30	%	%	NOUN
aiua-13762	184	31	ci	ci	NOUN
aiua-13762	184	32	,	,	PUNCT
aiua-13762	184	33	3.45	3.45	NUM
aiua-13762	184	34	-	-	SYM
aiua-13762	184	35	4.80	4.80	NUM
aiua-13762	184	36	)	)	PUNCT
aiua-13762	184	37	.	.	PUNCT
aiua-13762	185	1	however	however	ADV
aiua-13762	185	2	,	,	PUNCT
aiua-13762	185	3	the	the	DET
aiua-13762	185	4	metaanalysis	metaanalysis	NOUN
aiua-13762	185	5	including	include	VERB
aiua-13762	185	6	non	non	ADJ
aiua-13762	185	7	-	-	ADJ
aiua-13762	185	8	jewish	jewish	ADJ
aiua-13762	185	9	europeans	european	NOUN
aiua-13762	185	10	showed	show	VERB
aiua-13762	185	11	substantial	substantial	ADJ
aiua-13762	185	12	heterogeneity	heterogeneity	NOUN
aiua-13762	185	13	(	(	PUNCT
aiua-13762	185	14	i²	i²	NOUN
aiua-13762	185	15	=	=	PROPN
aiua-13762	185	16	66	66	NUM
aiua-13762	185	17	%	%	NOUN
aiua-13762	185	18	)	)	PUNCT
aiua-13762	185	19	,	,	PUNCT
aiua-13762	185	20	which	which	PRON
aiua-13762	185	21	was	be	AUX
aiua-13762	185	22	absent	absent	ADJ
aiua-13762	185	23	from	from	ADP
aiua-13762	185	24	the	the	DET
aiua-13762	185	25	analysis	analysis	NOUN
aiua-13762	185	26	including	include	VERB
aiua-13762	185	27	aj	aj	PROPN
aiua-13762	185	28	(	(	PUNCT
aiua-13762	185	29	i²	i²	NOUN
aiua-13762	185	30	=	=	NOUN
aiua-13762	185	31	0	0	NUM
aiua-13762	185	32	)	)	PUNCT
aiua-13762	185	33	.	.	PUNCT
aiua-13762	186	1	a	a	DET
aiua-13762	186	2	2023	2023	NUM
aiua-13762	186	3	meta	meta	ADJ
aiua-13762	186	4	-	-	PUNCT
aiua-13762	186	5	analysis	analysis	NOUN
aiua-13762	186	6	investigated	investigate	VERB
aiua-13762	186	7	the	the	DET
aiua-13762	186	8	prevalence	prevalence	NOUN
aiua-13762	186	9	of	of	ADP
aiua-13762	186	10	both	both	DET
aiua-13762	186	11	germline	germline	NOUN
aiua-13762	186	12	founder	founder	NOUN
aiua-13762	186	13	and	and	CCONJ
aiua-13762	186	14	non	non	ADJ
aiua-13762	186	15	-	-	ADJ
aiua-13762	186	16	founder	founder	ADJ
aiua-13762	186	17	mutations	mutation	NOUN
aiua-13762	186	18	in	in	ADP
aiua-13762	186	19	brca1	brca1	PROPN
aiua-13762	186	20	and	and	CCONJ
aiua-13762	186	21	brca2	brca2	PROPN
aiua-13762	186	22	among	among	ADP
aiua-13762	186	23	ashkenazi	ashkenazi	PROPN
aiua-13762	186	24	versus	versus	ADP
aiua-13762	186	25	non	non	ADJ
aiua-13762	186	26	-	-	ADJ
aiua-13762	186	27	ashkenazi	ashkenazi	ADJ
aiua-13762	186	28	pca	pca	NOUN
aiua-13762	186	29	patients	patient	NOUN
aiua-13762	186	30	(	(	PUNCT
aiua-13762	186	31	74	74	NUM
aiua-13762	186	32	)	)	PUNCT
aiua-13762	186	33	.	.	PUNCT
aiua-13762	187	1	the	the	DET
aiua-13762	187	2	study	study	NOUN
aiua-13762	187	3	found	find	VERB
aiua-13762	187	4	that	that	SCONJ
aiua-13762	187	5	ashkenazi	ashkenazi	ADJ
aiua-13762	187	6	jewish	jewish	ADJ
aiua-13762	187	7	men	man	NOUN
aiua-13762	187	8	had	have	VERB
aiua-13762	187	9	a	a	DET
aiua-13762	187	10	higher	high	ADJ
aiua-13762	187	11	prevalence	prevalence	NOUN
aiua-13762	187	12	of	of	ADP
aiua-13762	187	13	brca1	brca1	PROPN
aiua-13762	187	14	variants	variant	NOUN
aiua-13762	187	15	(	(	PUNCT
aiua-13762	187	16	0.9	0.9	NUM
aiua-13762	187	17	%	%	NOUN
aiua-13762	187	18	vs.	vs.	ADP
aiua-13762	187	19	0.5	0.5	NUM
aiua-13762	187	20	%	%	NOUN
aiua-13762	187	21	,	,	PUNCT
aiua-13762	187	22	p	p	NOUN
aiua-13762	187	23	=	=	NOUN
aiua-13762	187	24	0.09	0.09	NUM
aiua-13762	187	25	)	)	PUNCT
aiua-13762	187	26	and	and	CCONJ
aiua-13762	187	27	a	a	DET
aiua-13762	187	28	lower	low	ADJ
aiua-13762	187	29	prevalence	prevalence	NOUN
aiua-13762	187	30	of	of	ADP
aiua-13762	187	31	brca2	brca2	NOUN
aiua-13762	187	32	variants	variant	NOUN
aiua-13762	187	33	[	[	X
aiua-13762	187	34	1.5	1.5	NUM
aiua-13762	187	35	%	%	NOUN
aiua-13762	187	36	vs.	vs.	ADP
aiua-13762	187	37	3.5	3.5	NUM
aiua-13762	187	38	%	%	NOUN
aiua-13762	187	39	,	,	PUNCT
aiua-13762	187	40	p	p	X
aiua-13762	187	41	=	=	NOUN
aiua-13762	187	42	0.08	0.08	NUM
aiua-13762	187	43	]	]	PUNCT
aiua-13762	187	44	compared	compare	VERB
aiua-13762	187	45	to	to	ADP
aiua-13762	187	46	non	non	PRON
aiua-13762	187	47	ashkenazi	ashkenazi	ADJ
aiua-13762	187	48	patients	patient	NOUN
aiua-13762	187	49	,	,	PUNCT
aiua-13762	187	50	though	though	SCONJ
aiua-13762	187	51	the	the	DET
aiua-13762	187	52	p	p	PROPN
aiua-13762	187	53	values	value	NOUN
aiua-13762	187	54	do	do	AUX
aiua-13762	187	55	not	not	PART
aiua-13762	187	56	reach	reach	VERB
aiua-13762	187	57	statistical	statistical	ADJ
aiua-13762	187	58	significance	significance	NOUN
aiua-13762	187	59	.	.	PUNCT
aiua-13762	188	1	figure	figure	NOUN
aiua-13762	188	2	1	1	NUM
aiua-13762	188	3	presents	present	VERB
aiua-13762	188	4	a	a	DET
aiua-13762	188	5	pooled	pooled	ADJ
aiua-13762	188	6	summary	summary	NOUN
aiua-13762	188	7	of	of	ADP
aiua-13762	188	8	the	the	DET
aiua-13762	188	9	evidence	evidence	NOUN
aiua-13762	188	10	emerging	emerge	VERB
aiua-13762	188	11	from	from	ADP
aiua-13762	188	12	case	case	NOUN
aiua-13762	188	13	-	-	PUNCT
aiua-13762	188	14	control	control	NOUN
aiua-13762	188	15	studies	study	NOUN
aiua-13762	188	16	showing	show	VERB
aiua-13762	188	17	similar	similar	ADJ
aiua-13762	188	18	designs	design	NOUN
aiua-13762	188	19	.	.	PUNCT
aiua-13762	189	1	this	this	DET
aiua-13762	189	2	summary	summary	NOUN
aiua-13762	189	3	specifically	specifically	ADV
aiua-13762	189	4	excludes	exclude	VERB
aiua-13762	189	5	case	case	NOUN
aiua-13762	189	6	series	series	NOUN
aiua-13762	189	7	,	,	PUNCT
aiua-13762	189	8	single	single	ADJ
aiua-13762	189	9	-	-	PUNCT
aiua-13762	189	10	cohort	cohort	NOUN
aiua-13762	189	11	studies	study	NOUN
aiua-13762	189	12	,	,	PUNCT
aiua-13762	189	13	research	research	NOUN
aiua-13762	189	14	comparing	compare	VERB
aiua-13762	189	15	data	datum	NOUN
aiua-13762	189	16	to	to	ADP
aiua-13762	189	17	external	external	ADJ
aiua-13762	189	18	population	population	NOUN
aiua-13762	189	19	estimates	estimate	NOUN
aiua-13762	189	20	,	,	PUNCT
aiua-13762	189	21	and	and	CCONJ
aiua-13762	189	22	studies	study	NOUN
aiua-13762	189	23	utilizing	utilize	VERB
aiua-13762	189	24	controls	control	NOUN
aiua-13762	189	25	from	from	ADP
aiua-13762	189	26	either	either	CCONJ
aiua-13762	189	27	(	(	PUNCT
aiua-13762	189	28	i	i	NOUN
aiua-13762	189	29	)	)	PUNCT
aiua-13762	189	30	cohorts	cohort	NOUN
aiua-13762	189	31	published	publish	VERB
aiua-13762	189	32	by	by	ADP
aiua-13762	189	33	different	different	ADJ
aiua-13762	189	34	research	research	NOUN
aiua-13762	189	35	groups	group	NOUN
aiua-13762	189	36	or	or	CCONJ
aiua-13762	189	37	(	(	PUNCT
aiua-13762	189	38	ii	ii	NOUN
aiua-13762	189	39	)	)	PUNCT
aiua-13762	189	40	cohorts	cohort	NOUN
aiua-13762	189	41	including	include	VERB
aiua-13762	189	42	healthy	healthy	ADJ
aiua-13762	189	43	women	woman	NOUN
aiua-13762	189	44	.	.	PUNCT
aiua-13762	190	1	although	although	SCONJ
aiua-13762	190	2	these	these	DET
aiua-13762	190	3	findings	finding	NOUN
aiua-13762	190	4	are	be	AUX
aiua-13762	190	5	not	not	PART
aiua-13762	190	6	part	part	NOUN
aiua-13762	190	7	of	of	ADP
aiua-13762	190	8	a	a	DET
aiua-13762	190	9	comprehensive	comprehensive	ADJ
aiua-13762	190	10	meta	meta	ADJ
aiua-13762	190	11	-	-	PUNCT
aiua-13762	190	12	analysis	analysis	NOUN
aiua-13762	190	13	(	(	PUNCT
aiua-13762	190	14	currently	currently	ADV
aiua-13762	190	15	in	in	ADP
aiua-13762	190	16	preparation	preparation	NOUN
aiua-13762	190	17	)	)	PUNCT
aiua-13762	190	18	,	,	PUNCT
aiua-13762	190	19	the	the	DET
aiua-13762	190	20	data	datum	NOUN
aiua-13762	190	21	indicate	indicate	VERB
aiua-13762	190	22	a	a	DET
aiua-13762	190	23	significantly	significantly	ADV
aiua-13762	190	24	increased	increase	VERB
aiua-13762	190	25	odds	odd	NOUN
aiua-13762	190	26	ratio	ratio	NOUN
aiua-13762	190	27	for	for	ADP
aiua-13762	190	28	harboring	harbor	VERB
aiua-13762	190	29	the	the	DET
aiua-13762	190	30	brca2	brca2	NOUN
aiua-13762	190	31	6147delt	6147delt	PROPN
aiua-13762	190	32	mutation	mutation	NOUN
aiua-13762	190	33	in	in	ADP
aiua-13762	190	34	prostate	prostate	NOUN
aiua-13762	190	35	cancer	cancer	NOUN
aiua-13762	190	36	cases	case	NOUN
aiua-13762	190	37	(	(	PUNCT
aiua-13762	190	38	odds	odd	NOUN
aiua-13762	190	39	ratio	ratio	NOUN
aiua-13762	190	40	2.3	2.3	NUM
aiua-13762	190	41	,	,	PUNCT
aiua-13762	190	42	95	95	NUM
aiua-13762	190	43	%	%	NOUN
aiua-13762	190	44	ci	ci	NOUN
aiua-13762	190	45	1.59	1.59	NUM
aiua-13762	190	46	-	-	SYM
aiua-13762	190	47	3.43	3.43	NUM
aiua-13762	190	48	)	)	PUNCT
aiua-13762	190	49	compared	compare	VERB
aiua-13762	190	50	to	to	ADP
aiua-13762	190	51	controls	control	NOUN
aiua-13762	190	52	.	.	PUNCT
aiua-13762	191	1	these	these	DET
aiua-13762	191	2	findings	finding	NOUN
aiua-13762	191	3	align	align	VERB
aiua-13762	191	4	with	with	ADP
aiua-13762	191	5	those	those	PRON
aiua-13762	191	6	of	of	ADP
aiua-13762	191	7	previous	previous	ADJ
aiua-13762	191	8	meta	meta	NOUN
aiua-13762	191	9	-	-	PUNCT
aiua-13762	191	10	analyses	analysis	NOUN
aiua-13762	191	11	,	,	PUNCT
aiua-13762	191	12	which	which	PRON
aiua-13762	191	13	reported	report	VERB
aiua-13762	191	14	a	a	DET
aiua-13762	191	15	2.1	2.1	NUM
aiua-13762	191	16	risk	risk	NOUN
aiua-13762	191	17	rate	rate	NOUN
aiua-13762	191	18	(	(	PUNCT
aiua-13762	191	19	95	95	NUM
aiua-13762	191	20	%	%	NOUN
aiua-13762	191	21	ci	ci	NOUN
aiua-13762	191	22	1.6	1.6	NUM
aiua-13762	191	23	-	-	SYM
aiua-13762	191	24	2.6	2.6	NUM
aiua-13762	191	25	)	)	PUNCT
aiua-13762	191	26	and	and	CCONJ
aiua-13762	191	27	a	a	DET
aiua-13762	191	28	2.08	2.08	NUM
aiua-13762	191	29	risk	risk	NOUN
aiua-13762	191	30	ratio	ratio	NOUN
aiua-13762	191	31	(	(	PUNCT
aiua-13762	191	32	95	95	NUM
aiua-13762	191	33	%	%	NOUN
aiua-13762	191	34	ci	ci	NOUN
aiua-13762	191	35	1.38	1.38	NUM
aiua-13762	191	36	-	-	SYM
aiua-13762	191	37	3.12	3.12	NUM
aiua-13762	191	38	)	)	PUNCT
aiua-13762	191	39	for	for	ADP
aiua-13762	191	40	brca2	brca2	PROPN
aiua-13762	191	41	ashkenazi	ashkenazi	PROPN
aiua-13762	191	42	mutation	mutation	NOUN
aiua-13762	191	43	carriers	carrier	NOUN
aiua-13762	191	44	(	(	PUNCT
aiua-13762	191	45	72	72	NUM
aiua-13762	191	46	,	,	PUNCT
aiua-13762	191	47	73	73	NUM
aiua-13762	191	48	)	)	PUNCT
aiua-13762	191	49	.	.	PUNCT
aiua-13762	192	1	in	in	ADP
aiua-13762	192	2	conclusion	conclusion	NOUN
aiua-13762	192	3	,	,	PUNCT
aiua-13762	192	4	the	the	DET
aiua-13762	192	5	evidence	evidence	NOUN
aiua-13762	192	6	derived	derive	VERB
aiua-13762	192	7	from	from	ADP
aiua-13762	192	8	case	case	NOUN
aiua-13762	192	9	series	series	NOUN
aiua-13762	192	10	,	,	PUNCT
aiua-13762	192	11	cohort	cohort	NOUN
aiua-13762	192	12	studies	study	NOUN
aiua-13762	192	13	,	,	PUNCT
aiua-13762	192	14	and	and	CCONJ
aiua-13762	192	15	meta	meta	NOUN
aiua-13762	192	16	-	-	PUNCT
aiua-13762	192	17	analyses	analysis	NOUN
aiua-13762	192	18	suggests	suggest	VERB
aiua-13762	192	19	that	that	SCONJ
aiua-13762	192	20	the	the	DET
aiua-13762	192	21	rate	rate	NOUN
aiua-13762	192	22	of	of	ADP
aiua-13762	192	23	brca	brca	PROPN
aiua-13762	192	24	mutations	mutation	NOUN
aiua-13762	192	25	associated	associate	VERB
aiua-13762	192	26	with	with	ADP
aiua-13762	192	27	prostate	prostate	NOUN
aiua-13762	192	28	cancer	cancer	NOUN
aiua-13762	192	29	in	in	ADP
aiua-13762	192	30	ashkenazi	ashkenazi	ADJ
aiua-13762	192	31	jewish	jewish	ADJ
aiua-13762	192	32	men	man	NOUN
aiua-13762	192	33	may	may	AUX
aiua-13762	192	34	not	not	PART
aiua-13762	192	35	differ	differ	VERB
aiua-13762	192	36	significantly	significantly	ADV
aiua-13762	192	37	from	from	ADP
aiua-13762	192	38	that	that	PRON
aiua-13762	192	39	in	in	ADP
aiua-13762	192	40	the	the	DET
aiua-13762	192	41	general	general	ADJ
aiua-13762	192	42	population	population	NOUN
aiua-13762	192	43	.	.	PUNCT
aiua-13762	193	1	however	however	ADV
aiua-13762	193	2	,	,	PUNCT
aiua-13762	193	3	founder	founder	NOUN
aiua-13762	193	4	mutations	mutation	NOUN
aiua-13762	193	5	in	in	ADP
aiua-13762	193	6	brca2	brca2	PROPN
aiua-13762	193	7	,	,	PUNCT
aiua-13762	193	8	and	and	CCONJ
aiua-13762	193	9	to	to	ADP
aiua-13762	193	10	a	a	DET
aiua-13762	193	11	lesser	less	ADJ
aiua-13762	193	12	extent	extent	NOUN
aiua-13762	193	13	in	in	ADP
aiua-13762	193	14	brca1	brca1	PROPN
aiua-13762	193	15	are	be	AUX
aiua-13762	193	16	likely	likely	ADV
aiua-13762	193	17	linked	link	VERB
aiua-13762	193	18	to	to	ADP
aiua-13762	193	19	the	the	DET
aiua-13762	193	20	development	development	NOUN
aiua-13762	193	21	of	of	ADP
aiua-13762	193	22	prostate	prostate	NOUN
aiua-13762	193	23	cancer	cancer	NOUN
aiua-13762	193	24	among	among	ADP
aiua-13762	193	25	aj	aj	PROPN
aiua-13762	193	26	.	.	PROPN
aiua-13762	194	1	germline	germline	PROPN
aiua-13762	194	2	apc	apc	PROPN
aiua-13762	194	3	variants	variants	PROPN
aiua-13762	194	4	familial	familial	ADJ
aiua-13762	194	5	adenomatous	adenomatous	ADJ
aiua-13762	194	6	polyposis	polyposis	NOUN
aiua-13762	194	7	(	(	PUNCT
aiua-13762	194	8	fap	fap	NOUN
aiua-13762	194	9	)	)	PUNCT
aiua-13762	194	10	is	be	AUX
aiua-13762	194	11	an	an	DET
aiua-13762	194	12	autosomal	autosomal	ADJ
aiua-13762	194	13	dominant	dominant	ADJ
aiua-13762	194	14	inherited	inherit	VERB
aiua-13762	194	15	disorder	disorder	NOUN
aiua-13762	194	16	responsible	responsible	ADJ
aiua-13762	194	17	for	for	ADP
aiua-13762	194	18	up	up	ADP
aiua-13762	194	19	to	to	PART
aiua-13762	194	20	5	5	NUM
aiua-13762	194	21	%	%	NOUN
aiua-13762	194	22	of	of	ADP
aiua-13762	194	23	colorectal	colorectal	ADJ
aiua-13762	194	24	cancer	cancer	NOUN
aiua-13762	194	25	(	(	PUNCT
aiua-13762	194	26	crc	crc	NOUN
aiua-13762	194	27	)	)	PUNCT
aiua-13762	194	28	cases	case	NOUN
aiua-13762	194	29	.	.	PUNCT
aiua-13762	195	1	truncating	truncate	VERB
aiua-13762	195	2	mutations	mutation	NOUN
aiua-13762	195	3	in	in	ADP
aiua-13762	195	4	the	the	DET
aiua-13762	195	5	apc	apc	PROPN
aiua-13762	195	6	tumor	tumor	PROPN
aiua-13762	195	7	suppressor	suppressor	NOUN
aiua-13762	195	8	gene	gene	NOUN
aiua-13762	195	9	,	,	PUNCT
aiua-13762	195	10	which	which	PRON
aiua-13762	195	11	encodes	encode	VERB
aiua-13762	195	12	a	a	DET
aiua-13762	195	13	protein	protein	NOUN
aiua-13762	195	14	involved	involve	VERB
aiua-13762	195	15	in	in	ADP
aiua-13762	195	16	regulating	regulate	VERB
aiua-13762	195	17	β	β	NOUN
aiua-13762	195	18	-	-	NOUN
aiua-13762	195	19	catenin	catenin	NOUN
aiua-13762	195	20	via	via	ADP
aiua-13762	195	21	the	the	DET
aiua-13762	195	22	wnt	wnt	PROPN
aiua-13762	195	23	-	-	PUNCT
aiua-13762	195	24	ctnnb1	ctnnb1	NOUN
aiua-13762	195	25	signaling	signal	VERB
aiua-13762	195	26	pathway	pathway	NOUN
aiua-13762	195	27	,	,	PUNCT
aiua-13762	195	28	lead	lead	VERB
aiua-13762	195	29	to	to	ADP
aiua-13762	195	30	heterozygous	heterozygous	ADJ
aiua-13762	195	31	germline	germline	NOUN
aiua-13762	195	32	loss	loss	NOUN
aiua-13762	195	33	-	-	PUNCT
aiua-13762	195	34	offunction	offunction	NOUN
aiua-13762	195	35	alterations	alteration	NOUN
aiua-13762	195	36	in	in	ADP
aiua-13762	195	37	fap	fap	NOUN
aiua-13762	195	38	families	family	NOUN
aiua-13762	195	39	,	,	PUNCT
aiua-13762	195	40	resulting	result	VERB
aiua-13762	195	41	in	in	ADP
aiua-13762	195	42	the	the	DET
aiua-13762	195	43	onset	onset	NOUN
aiua-13762	195	44	of	of	ADP
aiua-13762	195	45	forms	form	NOUN
aiua-13762	195	46	of	of	ADP
aiua-13762	195	47	polyposis	polyposis	NOUN
aiua-13762	195	48	which	which	PRON
aiua-13762	195	49	can	can	AUX
aiua-13762	195	50	ultimately	ultimately	ADV
aiua-13762	195	51	progress	progress	VERB
aiua-13762	195	52	to	to	ADP
aiua-13762	195	53	crc	crc	PROPN
aiua-13762	195	54	.	.	PUNCT
aiua-13762	196	1	two	two	NUM
aiua-13762	196	2	case	case	NOUN
aiua-13762	196	3	series	series	NOUN
aiua-13762	196	4	have	have	AUX
aiua-13762	196	5	reported	report	VERB
aiua-13762	196	6	loh	loh	PROPN
aiua-13762	196	7	at	at	ADP
aiua-13762	196	8	the	the	DET
aiua-13762	196	9	apc	apc	PROPN
aiua-13762	196	10	locus	locus	PROPN
aiua-13762	196	11	,	,	PUNCT
aiua-13762	196	12	detected	detect	VERB
aiua-13762	196	13	in	in	ADP
aiua-13762	196	14	3	3	NUM
aiua-13762	196	15	out	out	ADP
aiua-13762	196	16	of	of	ADP
aiua-13762	196	17	7	7	NUM
aiua-13762	196	18	and	and	CCONJ
aiua-13762	196	19	3	3	NUM
aiua-13762	196	20	out	out	ADP
aiua-13762	196	21	of	of	ADP
aiua-13762	196	22	15	15	NUM
aiua-13762	196	23	metastatic	metastatic	ADJ
aiua-13762	196	24	prostate	prostate	NOUN
aiua-13762	196	25	cancer	cancer	NOUN
aiua-13762	196	26	cases	case	NOUN
aiua-13762	196	27	,	,	PUNCT
aiua-13762	196	28	respectively	respectively	ADV
aiua-13762	196	29	(	(	PUNCT
aiua-13762	196	30	75	75	NUM
aiua-13762	196	31	,	,	PUNCT
aiua-13762	196	32	76	76	NUM
aiua-13762	196	33	)	)	PUNCT
aiua-13762	196	34	.	.	PUNCT
aiua-13762	197	1	in	in	ADP
aiua-13762	197	2	the	the	DET
aiua-13762	197	3	late	late	ADJ
aiua-13762	197	4	1990s	1990	NOUN
aiua-13762	197	5	,	,	PUNCT
aiua-13762	197	6	a	a	DET
aiua-13762	197	7	tto	tto	NOUN
aiua-13762	197	8	-	-	PUNCT
aiua-13762	197	9	a	a	DET
aiua-13762	197	10	transversion	transversion	NOUN
aiua-13762	197	11	at	at	ADP
aiua-13762	197	12	nucleotide	nucleotide	NOUN
aiua-13762	197	13	3920	3920	NUM
aiua-13762	197	14	of	of	ADP
aiua-13762	197	15	apc	apc	PROPN
aiua-13762	197	16	,	,	PUNCT
aiua-13762	197	17	present	present	ADJ
aiua-13762	197	18	in	in	ADP
aiua-13762	197	19	10	10	NUM
aiua-13762	197	20	%	%	NOUN
aiua-13762	197	21	of	of	ADP
aiua-13762	197	22	ashkenazim	ashkenazim	NOUN
aiua-13762	197	23	and	and	CCONJ
aiua-13762	197	24	2.7	2.7	NUM
aiua-13762	197	25	%	%	NOUN
aiua-13762	197	26	of	of	ADP
aiua-13762	197	27	sephardic	sephardic	ADJ
aiua-13762	197	28	jews	jews	PROPN
aiua-13762	197	29	,	,	PUNCT
aiua-13762	197	30	causing	cause	VERB
aiua-13762	197	31	an	an	DET
aiua-13762	197	32	isoleucine	isoleucine	NOUN
aiua-13762	197	33	-	-	PUNCT
aiua-13762	197	34	to	to	ADP
aiua-13762	197	35	-	-	PUNCT
aiua-13762	197	36	lysine	lysine	NOUN
aiua-13762	197	37	substitution	substitution	NOUN
aiua-13762	197	38	at	at	ADP
aiua-13762	197	39	codon	codon	PROPN
aiua-13762	197	40	1307	1307	NUM
aiua-13762	197	41	was	be	AUX
aiua-13762	197	42	described	describe	VERB
aiua-13762	197	43	.	.	PUNCT
aiua-13762	198	1	this	this	DET
aiua-13762	198	2	alteration	alteration	NOUN
aiua-13762	198	3	creates	create	VERB
aiua-13762	198	4	a	a	DET
aiua-13762	198	5	genetically	genetically	ADV
aiua-13762	198	6	unstable	unstable	ADJ
aiua-13762	198	7	and	and	CCONJ
aiua-13762	198	8	hypermutable	hypermutable	ADJ
aiua-13762	198	9	region	region	NOUN
aiua-13762	198	10	of	of	ADP
aiua-13762	198	11	the	the	DET
aiua-13762	198	12	gene	gene	NOUN
aiua-13762	198	13	,	,	PUNCT
aiua-13762	198	14	and	and	CCONJ
aiua-13762	198	15	was	be	AUX
aiua-13762	198	16	found	find	VERB
aiua-13762	198	17	to	to	PART
aiua-13762	198	18	be	be	AUX
aiua-13762	198	19	highly	highly	ADV
aiua-13762	198	20	prevalent	prevalent	ADJ
aiua-13762	198	21	(	(	PUNCT
aiua-13762	198	22	28	28	NUM
aiua-13762	198	23	%	%	NOUN
aiua-13762	198	24	)	)	PUNCT
aiua-13762	198	25	among	among	ADP
aiua-13762	198	26	aj	aj	PROPN
aiua-13762	198	27	with	with	ADP
aiua-13762	198	28	a	a	DET
aiua-13762	198	29	family	family	NOUN
aiua-13762	198	30	history	history	NOUN
aiua-13762	198	31	of	of	ADP
aiua-13762	198	32	crc	crc	NOUN
aiua-13762	198	33	(	(	PUNCT
aiua-13762	198	34	77	77	NUM
aiua-13762	198	35	-	-	SYM
aiua-13762	198	36	79	79	NUM
aiua-13762	198	37	)	)	PUNCT
aiua-13762	198	38	.	.	PUNCT
aiua-13762	199	1	case	case	NOUN
aiua-13762	199	2	studies	study	NOUN
aiua-13762	199	3	indicated	indicate	VERB
aiua-13762	199	4	that	that	SCONJ
aiua-13762	199	5	relatives	relative	NOUN
aiua-13762	199	6	of	of	ADP
aiua-13762	199	7	crc	crc	NOUN
aiua-13762	199	8	patients	patient	NOUN
aiua-13762	199	9	carrying	carry	VERB
aiua-13762	199	10	the	the	DET
aiua-13762	199	11	i1307k	i1307k	PROPN
aiua-13762	199	12	substitution	substitution	NOUN
aiua-13762	199	13	had	have	VERB
aiua-13762	199	14	family	family	NOUN
aiua-13762	199	15	histories	history	NOUN
aiua-13762	199	16	of	of	ADP
aiua-13762	199	17	various	various	ADJ
aiua-13762	199	18	cancers	cancer	NOUN
aiua-13762	199	19	,	,	PUNCT
aiua-13762	199	20	including	include	VERB
aiua-13762	199	21	pca	pca	PROPN
aiua-13762	199	22	(	(	PUNCT
aiua-13762	199	23	80	80	NUM
aiua-13762	199	24	)	)	PUNCT
aiua-13762	199	25	.	.	PUNCT
aiua-13762	200	1	woodage	woodage	NOUN
aiua-13762	200	2	and	and	CCONJ
aiua-13762	200	3	colleagues	colleague	NOUN
aiua-13762	200	4	investigated	investigate	VERB
aiua-13762	200	5	a	a	DET
aiua-13762	200	6	cohort	cohort	NOUN
aiua-13762	200	7	of	of	ADP
aiua-13762	200	8	5081	5081	NUM
aiua-13762	200	9	ashkenazim	ashkenazim	NOUN
aiua-13762	200	10	carrying	carry	VERB
aiua-13762	200	11	either	either	CCONJ
aiua-13762	200	12	a	a	DET
aiua-13762	200	13	homoor	homoor	NOUN
aiua-13762	200	14	heterozygous	heterozygous	ADJ
aiua-13762	200	15	i1307k	i1307k	NOUN
aiua-13762	200	16	substitution	substitution	NOUN
aiua-13762	200	17	.	.	PUNCT
aiua-13762	201	1	the	the	DET
aiua-13762	201	2	odds	odd	NOUN
aiua-13762	201	3	ratio	ratio	NOUN
aiua-13762	201	4	for	for	ADP
aiua-13762	201	5	pca	pca	PROPN
aiua-13762	201	6	was	be	AUX
aiua-13762	201	7	2.0	2.0	NUM
aiua-13762	201	8	,	,	PUNCT
aiua-13762	201	9	but	but	CCONJ
aiua-13762	201	10	the	the	DET
aiua-13762	201	11	wide	wide	ADJ
aiua-13762	201	12	confidence	confidence	NOUN
aiua-13762	201	13	interval	interval	NOUN
aiua-13762	201	14	(	(	PUNCT
aiua-13762	201	15	0.81	0.81	NUM
aiua-13762	201	16	-	-	SYM
aiua-13762	201	17	4.7	4.7	NUM
aiua-13762	201	18	)	)	PUNCT
aiua-13762	201	19	precluded	preclude	VERB
aiua-13762	201	20	statistical	statistical	ADJ
aiua-13762	201	21	significance	significance	NOUN
aiua-13762	201	22	(	(	PUNCT
aiua-13762	201	23	81	81	NUM
aiua-13762	201	24	)	)	PUNCT
aiua-13762	201	25	.	.	PUNCT
aiua-13762	202	1	a	a	DET
aiua-13762	202	2	2006	2006	NUM
aiua-13762	202	3	kin	kin	ADJ
aiua-13762	202	4	-	-	PUNCT
aiua-13762	202	5	cohort	cohort	NOUN
aiua-13762	202	6	study	study	NOUN
aiua-13762	202	7	comparing	compare	VERB
aiua-13762	202	8	relatives	relative	NOUN
aiua-13762	202	9	of	of	ADP
aiua-13762	202	10	i1307k	i1307k	NOUN
aiua-13762	202	11	carriers	carrier	NOUN
aiua-13762	202	12	with	with	ADP
aiua-13762	202	13	non	non	NOUN
aiua-13762	202	14	-	-	NOUN
aiua-13762	202	15	carriers	carrier	NOUN
aiua-13762	202	16	observed	observe	VERB
aiua-13762	202	17	a	a	DET
aiua-13762	202	18	higher	high	ADJ
aiua-13762	202	19	incidence	incidence	NOUN
aiua-13762	202	20	of	of	ADP
aiua-13762	202	21	pca	pca	NOUN
aiua-13762	202	22	in	in	ADP
aiua-13762	202	23	relatives	relative	NOUN
aiua-13762	202	24	of	of	ADP
aiua-13762	202	25	i1307k	i1307k	NOUN
aiua-13762	202	26	carriers	carrier	NOUN
aiua-13762	202	27	over	over	ADP
aiua-13762	202	28	the	the	DET
aiua-13762	202	29	age	age	NOUN
aiua-13762	202	30	of	of	ADP
aiua-13762	202	31	80	80	NUM
aiua-13762	202	32	,	,	PUNCT
aiua-13762	202	33	compared	compare	VERB
aiua-13762	202	34	to	to	ADP
aiua-13762	202	35	non	non	NOUN
aiua-13762	202	36	-	-	NOUN
aiua-13762	202	37	carriers	carrier	NOUN
aiua-13762	202	38	,	,	PUNCT
aiua-13762	202	39	although	although	SCONJ
aiua-13762	202	40	the	the	DET
aiua-13762	202	41	difference	difference	NOUN
aiua-13762	202	42	was	be	AUX
aiua-13762	202	43	not	not	PART
aiua-13762	202	44	statistically	statistically	ADV
aiua-13762	202	45	significant	significant	ADJ
aiua-13762	202	46	(	(	PUNCT
aiua-13762	202	47	82	82	NUM
aiua-13762	202	48	)	)	PUNCT
aiua-13762	202	49	.	.	PUNCT
aiua-13762	203	1	conclusive	conclusive	ADJ
aiua-13762	203	2	evidence	evidence	NOUN
aiua-13762	203	3	of	of	ADP
aiua-13762	203	4	an	an	DET
aiua-13762	203	5	association	association	NOUN
aiua-13762	203	6	between	between	ADP
aiua-13762	203	7	i1307k	i1307k	PROPN
aiua-13762	203	8	and	and	CCONJ
aiua-13762	203	9	pca	pca	PROPN
aiua-13762	203	10	is	be	AUX
aiua-13762	203	11	still	still	ADV
aiua-13762	203	12	to	to	PART
aiua-13762	203	13	be	be	AUX
aiua-13762	203	14	confirmed	confirm	VERB
aiua-13762	203	15	.	.	PUNCT
aiua-13762	204	1	conversely	conversely	ADV
aiua-13762	204	2	,	,	PUNCT
aiua-13762	204	3	a	a	DET
aiua-13762	204	4	2023	2023	NUM
aiua-13762	204	5	case	case	NOUN
aiua-13762	204	6	series	series	NOUN
aiua-13762	204	7	demonstrated	demonstrate	VERB
aiua-13762	204	8	that	that	SCONJ
aiua-13762	204	9	,	,	PUNCT
aiua-13762	204	10	compared	compare	VERB
aiua-13762	204	11	to	to	ADP
aiua-13762	204	12	non	non	ADJ
aiua-13762	204	13	-	-	ADJ
aiua-13762	204	14	carrier	carrier	ADJ
aiua-13762	204	15	cancer	cancer	NOUN
aiua-13762	204	16	patients	patient	NOUN
aiua-13762	204	17	with	with	ADP
aiua-13762	204	18	somatic	somatic	ADJ
aiua-13762	204	19	frameshift	frameshift	NOUN
aiua-13762	204	20	mutations	mutation	NOUN
aiua-13762	204	21	of	of	ADP
aiua-13762	204	22	apc	apc	PROPN
aiua-13762	204	23	(	(	PUNCT
aiua-13762	204	24	n	n	NOUN
aiua-13762	204	25	=	=	NUM
aiua-13762	204	26	20	20	NUM
aiua-13762	204	27	)	)	PUNCT
aiua-13762	204	28	,	,	PUNCT
aiua-13762	204	29	carriers	carrier	NOUN
aiua-13762	204	30	of	of	ADP
aiua-13762	204	31	the	the	DET
aiua-13762	204	32	germline	germline	NOUN
aiua-13762	204	33	i1307k	i1307k	PROPN
aiua-13762	204	34	substitution	substitution	NOUN
aiua-13762	204	35	(	(	PUNCT
aiua-13762	204	36	n	n	NOUN
aiua-13762	204	37	=	=	SYM
aiua-13762	204	38	18	18	NUM
aiua-13762	204	39	)	)	PUNCT
aiua-13762	204	40	had	have	VERB
aiua-13762	204	41	a	a	DET
aiua-13762	204	42	significantly	significantly	ADV
aiua-13762	204	43	increased	increase	VERB
aiua-13762	204	44	odds	odd	NOUN
aiua-13762	204	45	of	of	ADP
aiua-13762	204	46	presenting	present	VERB
aiua-13762	204	47	with	with	ADP
aiua-13762	204	48	the	the	DET
aiua-13762	204	49	severe	severe	ADJ
aiua-13762	204	50	and	and	CCONJ
aiua-13762	204	51	untreatable	untreatable	ADJ
aiua-13762	204	52	"	"	PUNCT
aiua-13762	204	53	aggressive	aggressive	ADJ
aiua-13762	204	54	variant	variant	NOUN
aiua-13762	204	55	of	of	ADP
aiua-13762	204	56	prostate	prostate	NOUN
aiua-13762	204	57	cancer	cancer	NOUN
aiua-13762	204	58	"	"	PUNCT
aiua-13762	204	59	(	(	PUNCT
aiua-13762	204	60	avpc	avpc	PROPN
aiua-13762	204	61	,	,	PUNCT
aiua-13762	204	62	odds	odd	NOUN
aiua-13762	204	63	ratio	ratio	NOUN
aiua-13762	204	64	:	:	PUNCT
aiua-13762	204	65	7.2	7.2	NUM
aiua-13762	204	66	;	;	PUNCT
aiua-13762	204	67	95	95	NUM
aiua-13762	204	68	%	%	NOUN
aiua-13762	204	69	ci	ci	NOUN
aiua-13762	204	70	:	:	PUNCT
aiua-13762	204	71	1.3	1.3	NUM
aiua-13762	204	72	-	-	SYM
aiua-13762	204	73	40.7	40.7	NUM
aiua-13762	204	74	)	)	PUNCT
aiua-13762	204	75	(	(	PUNCT
aiua-13762	204	76	83	83	NUM
aiua-13762	204	77	)	)	PUNCT
aiua-13762	204	78	,	,	PUNCT
aiua-13762	204	79	defined	define	VERB
aiua-13762	204	80	as	as	ADP
aiua-13762	204	81	an	an	DET
aiua-13762	204	82	androgen	androgen	NOUN
aiua-13762	204	83	receptor	receptor	NOUN
aiua-13762	204	84	independent	independent	ADJ
aiua-13762	204	85	neoplasia	neoplasia	NOUN
aiua-13762	204	86	characterized	characterize	VERB
aiua-13762	204	87	by	by	ADP
aiua-13762	204	88	a	a	DET
aiua-13762	204	89	unique	unique	ADJ
aiua-13762	204	90	array	array	NOUN
aiua-13762	204	91	of	of	ADP
aiua-13762	204	92	genetic	genetic	ADJ
aiua-13762	204	93	(	(	PUNCT
aiua-13762	204	94	e.g.	e.g.	ADV
aiua-13762	204	95	,	,	PUNCT
aiua-13762	204	96	rb1	rb1	PROPN
aiua-13762	204	97	,	,	PUNCT
aiua-13762	204	98	tp53	tp53	PROPN
aiua-13762	204	99	,	,	PUNCT
aiua-13762	204	100	or	or	CCONJ
aiua-13762	204	101	pten	pten	VERB
aiua-13762	204	102	mutations	mutation	NOUN
aiua-13762	204	103	)	)	PUNCT
aiua-13762	204	104	and	and	CCONJ
aiua-13762	204	105	cellular	cellular	ADJ
aiua-13762	204	106	characteristics	characteristic	NOUN
aiua-13762	204	107	(	(	PUNCT
aiua-13762	204	108	e.g.	e.g.	ADV
aiua-13762	204	109	,	,	PUNCT
aiua-13762	204	110	small	small	ADJ
aiua-13762	204	111	cell	cell	NOUN
aiua-13762	204	112	histology	histology	NOUN
aiua-13762	204	113	)	)	PUNCT
aiua-13762	204	114	,	,	PUNCT
aiua-13762	204	115	making	make	VERB
aiua-13762	204	116	the	the	DET
aiua-13762	204	117	disease	disease	NOUN
aiua-13762	204	118	virtually	virtually	ADV
aiua-13762	204	119	untreatable	untreatable	ADJ
aiua-13762	204	120	.	.	PUNCT
aiua-13762	205	1	among	among	ADP
aiua-13762	205	2	the	the	DET
aiua-13762	205	3	i1307k	i1307k	NOUN
aiua-13762	205	4	carriers	carrier	NOUN
aiua-13762	205	5	(	(	PUNCT
aiua-13762	205	6	100	100	NUM
aiua-13762	205	7	%	%	NOUN
aiua-13762	205	8	aj	aj	PROPN
aiua-13762	205	9	,	,	PUNCT
aiua-13762	205	10	personal	personal	ADJ
aiua-13762	205	11	communication	communication	NOUN
aiua-13762	205	12	from	from	ADP
aiua-13762	205	13	the	the	DET
aiua-13762	205	14	corresponding	corresponding	ADJ
aiua-13762	205	15	author	author	NOUN
aiua-13762	205	16	)	)	PUNCT
aiua-13762	205	17	,	,	PUNCT
aiua-13762	205	18	five	five	NUM
aiua-13762	205	19	patients	patient	NOUN
aiua-13762	205	20	had	have	VERB
aiua-13762	205	21	somatic	somatic	ADJ
aiua-13762	205	22	alterations	alteration	NOUN
aiua-13762	205	23	in	in	ADP
aiua-13762	205	24	one	one	NUM
aiua-13762	205	25	or	or	CCONJ
aiua-13762	205	26	more	more	ADJ
aiua-13762	205	27	of	of	ADP
aiua-13762	205	28	the	the	DET
aiua-13762	205	29	rb1	rb1	NOUN
aiua-13762	205	30	,	,	PUNCT
aiua-13762	205	31	tp53	tp53	PROPN
aiua-13762	205	32	,	,	PUNCT
aiua-13762	205	33	or	or	CCONJ
aiua-13762	205	34	pten	pten	VERB
aiua-13762	205	35	tumor	tumor	NOUN
aiua-13762	205	36	suppressors	suppressor	NOUN
aiua-13762	205	37	,	,	PUNCT
aiua-13762	205	38	and	and	CCONJ
aiua-13762	205	39	two	two	NUM
aiua-13762	205	40	exhibited	exhibit	VERB
aiua-13762	205	41	the	the	DET
aiua-13762	205	42	aj	aj	PROPN
aiua-13762	205	43	founder	founder	NOUN
aiua-13762	205	44	mutation	mutation	NOUN
aiua-13762	205	45	s1982fs*22	s1982fs*22	NOUN
aiua-13762	205	46	(	(	PUNCT
aiua-13762	205	47	6147delt	6147delt	PROPN
aiua-13762	205	48	)	)	PUNCT
aiua-13762	205	49	in	in	ADP
aiua-13762	205	50	brca2	brca2	PROPN
aiua-13762	205	51	.	.	PUNCT
aiua-13762	206	1	in	in	ADP
aiua-13762	206	2	summary	summary	NOUN
aiua-13762	206	3	,	,	PUNCT
aiua-13762	206	4	while	while	SCONJ
aiua-13762	206	5	increased	increase	VERB
aiua-13762	206	6	odds	odd	NOUN
aiua-13762	206	7	ratios	ratio	NOUN
aiua-13762	206	8	suggest	suggest	VERB
aiua-13762	206	9	a	a	DET
aiua-13762	206	10	potential	potential	ADJ
aiua-13762	206	11	association	association	NOUN
aiua-13762	206	12	between	between	ADP
aiua-13762	206	13	i1307k	i1307k	PROPN
aiua-13762	206	14	and	and	CCONJ
aiua-13762	206	15	pca	pca	PROPN
aiua-13762	206	16	,	,	PUNCT
aiua-13762	206	17	small	small	ADJ
aiua-13762	206	18	sample	sample	NOUN
aiua-13762	206	19	sizes	size	NOUN
aiua-13762	206	20	and/or	and/or	CCONJ
aiua-13762	206	21	the	the	DET
aiua-13762	206	22	limited	limited	ADJ
aiua-13762	206	23	number	number	NOUN
aiua-13762	206	24	of	of	ADP
aiua-13762	206	25	mutation	mutation	NOUN
aiua-13762	206	26	carriers	carrier	NOUN
aiua-13762	206	27	resulted	result	VERB
aiua-13762	206	28	in	in	ADP
aiua-13762	206	29	large	large	ADJ
aiua-13762	206	30	confidence	confidence	NOUN
aiua-13762	206	31	intervals	interval	NOUN
aiua-13762	206	32	preventing	prevent	VERB
aiua-13762	206	33	the	the	DET
aiua-13762	206	34	confirmation	confirmation	NOUN
aiua-13762	206	35	of	of	ADP
aiua-13762	206	36	statistical	statistical	ADJ
aiua-13762	206	37	significance	significance	NOUN
aiua-13762	206	38	.	.	PUNCT
aiua-13762	207	1	studies	study	NOUN
aiua-13762	207	2	conducted	conduct	VERB
aiua-13762	207	3	on	on	ADP
aiua-13762	207	4	larger	large	ADJ
aiua-13762	207	5	patient	patient	ADJ
aiua-13762	207	6	populations	population	NOUN
aiua-13762	207	7	are	be	AUX
aiua-13762	207	8	required	require	VERB
aiua-13762	207	9	to	to	PART
aiua-13762	207	10	provide	provide	VERB
aiua-13762	207	11	data	datum	NOUN
aiua-13762	207	12	for	for	ADP
aiua-13762	207	13	a	a	DET
aiua-13762	207	14	more	more	ADV
aiua-13762	207	15	conclusive	conclusive	ADJ
aiua-13762	207	16	assessment	assessment	NOUN
aiua-13762	207	17	of	of	ADP
aiua-13762	207	18	this	this	DET
aiua-13762	207	19	association	association	NOUN
aiua-13762	207	20	.	.	PUNCT
aiua-13762	208	1	pca	pca	PROPN
aiua-13762	208	2	incidence	incidence	NOUN
aiua-13762	208	3	in	in	ADP
aiua-13762	208	4	lynch	lynch	PROPN
aiua-13762	208	5	syndrome	syndrome	PROPN
aiua-13762	208	6	patients	patient	NOUN
aiua-13762	208	7	lynch	lynch	PROPN
aiua-13762	208	8	syndrome	syndrome	PROPN
aiua-13762	208	9	(	(	PUNCT
aiua-13762	208	10	ls	ls	PROPN
aiua-13762	208	11	)	)	PUNCT
aiua-13762	208	12	,	,	PUNCT
aiua-13762	208	13	also	also	ADV
aiua-13762	208	14	known	know	VERB
aiua-13762	208	15	as	as	ADP
aiua-13762	208	16	hereditary	hereditary	ADJ
aiua-13762	208	17	non	non	ADJ
aiua-13762	208	18	-	-	ADJ
aiua-13762	208	19	polyposis	polyposis	ADJ
aiua-13762	208	20	colorectal	colorectal	ADJ
aiua-13762	208	21	cancer	cancer	NOUN
aiua-13762	208	22	,	,	PUNCT
aiua-13762	208	23	is	be	AUX
aiua-13762	208	24	an	an	DET
aiua-13762	208	25	autosomal	autosomal	ADJ
aiua-13762	208	26	dominant	dominant	ADJ
aiua-13762	208	27	genetic	genetic	ADJ
aiua-13762	208	28	disorder	disorder	NOUN
aiua-13762	208	29	caused	cause	VERB
aiua-13762	208	30	by	by	ADP
aiua-13762	208	31	mutations	mutation	NOUN
aiua-13762	208	32	in	in	ADP
aiua-13762	208	33	specific	specific	ADJ
aiua-13762	208	34	dna	dna	PROPN
aiua-13762	208	35	mismatch	mismatch	NOUN
aiua-13762	208	36	repair	repair	NOUN
aiua-13762	208	37	(	(	PUNCT
aiua-13762	208	38	mmr	mmr	PROPN
aiua-13762	208	39	)	)	PUNCT
aiua-13762	208	40	genes	gene	NOUN
aiua-13762	208	41	,	,	PUNCT
aiua-13762	208	42	including	include	VERB
aiua-13762	208	43	mlh1	mlh1	PROPN
aiua-13762	208	44	,	,	PUNCT
aiua-13762	208	45	msh2	msh2	NOUN
aiua-13762	208	46	,	,	PUNCT
aiua-13762	208	47	msh6	msh6	NOUN
aiua-13762	208	48	,	,	PUNCT
aiua-13762	208	49	and	and	CCONJ
aiua-13762	208	50	pms2	pms2	PROPN
aiua-13762	208	51	.	.	PUNCT
aiua-13762	209	1	pathogenic	pathogenic	ADJ
aiua-13762	209	2	mutations	mutation	NOUN
aiua-13762	209	3	in	in	ADP
aiua-13762	209	4	these	these	DET
aiua-13762	209	5	genes	gene	NOUN
aiua-13762	209	6	increase	increase	VERB
aiua-13762	209	7	the	the	DET
aiua-13762	209	8	risk	risk	NOUN
aiua-13762	209	9	of	of	ADP
aiua-13762	209	10	several	several	ADJ
aiua-13762	209	11	cancers	cancer	NOUN
aiua-13762	209	12	,	,	PUNCT
aiua-13762	209	13	notably	notably	ADV
aiua-13762	209	14	colorectal	colorectal	ADJ
aiua-13762	209	15	and	and	CCONJ
aiua-13762	209	16	endometrial	endometrial	ADJ
aiua-13762	209	17	cancers	cancer	NOUN
aiua-13762	209	18	,	,	PUNCT
aiua-13762	209	19	as	as	ADV
aiua-13762	209	20	well	well	ADV
aiua-13762	209	21	as	as	ADP
aiua-13762	209	22	ovarian	ovarian	ADJ
aiua-13762	209	23	,	,	PUNCT
aiua-13762	209	24	stomach	stomach	NOUN
aiua-13762	209	25	,	,	PUNCT
aiua-13762	209	26	renal	renal	ADJ
aiua-13762	209	27	pelvis	pelvis	NOUN
aiua-13762	209	28	,	,	PUNCT
aiua-13762	209	29	and	and	CCONJ
aiua-13762	209	30	ureteral	ureteral	ADJ
aiua-13762	209	31	cancers	cancer	NOUN
aiua-13762	209	32	.	.	PUNCT
aiua-13762	210	1	a	a	DET
aiua-13762	210	2	2014	2014	NUM
aiua-13762	210	3	study	study	NOUN
aiua-13762	210	4	by	by	ADP
aiua-13762	210	5	haraldsottir	haraldsottir	NOUN
aiua-13762	210	6	which	which	PRON
aiua-13762	210	7	involved	involve	VERB
aiua-13762	210	8	188	188	NUM
aiua-13762	210	9	ls	ls	ADJ
aiua-13762	210	10	men	man	NOUN
aiua-13762	210	11	from	from	ADP
aiua-13762	210	12	the	the	DET
aiua-13762	210	13	us	us	PROPN
aiua-13762	210	14	,	,	PUNCT
aiua-13762	210	15	demonstrated	demonstrate	VERB
aiua-13762	210	16	a	a	DET
aiua-13762	210	17	significantly	significantly	ADV
aiua-13762	210	18	higher	high	ADJ
aiua-13762	210	19	incidence	incidence	NOUN
aiua-13762	210	20	of	of	ADP
aiua-13762	210	21	pca	pca	NOUN
aiua-13762	210	22	in	in	ADP
aiua-13762	210	23	these	these	DET
aiua-13762	210	24	individuals	individual	NOUN
aiua-13762	210	25	compared	compare	VERB
aiua-13762	210	26	to	to	ADP
aiua-13762	210	27	the	the	DET
aiua-13762	210	28	general	general	ADJ
aiua-13762	210	29	population	population	NOUN
aiua-13762	210	30	,	,	PUNCT
aiua-13762	210	31	with	with	ADP
aiua-13762	210	32	a	a	DET
aiua-13762	210	33	standardized	standardized	ADJ
aiua-13762	210	34	rate	rate	NOUN
aiua-13762	210	35	ratio	ratio	NOUN
aiua-13762	210	36	of	of	ADP
aiua-13762	210	37	4.87	4.87	NUM
aiua-13762	210	38	(	(	PUNCT
aiua-13762	210	39	95	95	NUM
aiua-13762	210	40	%	%	NOUN
aiua-13762	210	41	ci	ci	NOUN
aiua-13762	210	42	,	,	PUNCT
aiua-13762	210	43	2.43	2.43	NUM
aiua-13762	210	44	-	-	SYM
aiua-13762	210	45	8.71	8.71	NUM
aiua-13762	210	46	)	)	PUNCT
aiua-13762	210	47	(	(	PUNCT
aiua-13762	210	48	84	84	NUM
aiua-13762	210	49	)	)	PUNCT
aiua-13762	210	50	.	.	PUNCT
aiua-13762	211	1	mutations	mutation	NOUN
aiua-13762	211	2	were	be	AUX
aiua-13762	211	3	identified	identify	VERB
aiua-13762	211	4	in	in	ADP
aiua-13762	211	5	all	all	DET
aiua-13762	211	6	aforementioned	aforementione	VERB
aiua-13762	211	7	mmr	mmr	PROPN
aiua-13762	211	8	genes	gene	NOUN
aiua-13762	211	9	.	.	PUNCT
aiua-13762	212	1	in	in	ADP
aiua-13762	212	2	the	the	DET
aiua-13762	212	3	same	same	ADJ
aiua-13762	212	4	year	year	NOUN
aiua-13762	212	5	,	,	PUNCT
aiua-13762	212	6	a	a	DET
aiua-13762	212	7	meta	meta	ADJ
aiua-13762	212	8	-	-	PUNCT
aiua-13762	212	9	analysis	analysis	NOUN
aiua-13762	212	10	,	,	PUNCT
aiua-13762	212	11	which	which	PRON
aiua-13762	212	12	included	include	VERB
aiua-13762	212	13	both	both	DET
aiua-13762	212	14	molecular	molecular	ADJ
aiua-13762	212	15	studies	study	NOUN
aiua-13762	212	16	and	and	CCONJ
aiua-13762	212	17	family	family	NOUN
aiua-13762	212	18	/	/	SYM
aiua-13762	212	19	population	population	NOUN
aiua-13762	212	20	risk	risk	NOUN
aiua-13762	212	21	studies	study	NOUN
aiua-13762	212	22	,	,	PUNCT
aiua-13762	212	23	confirmed	confirm	VERB
aiua-13762	212	24	the	the	DET
aiua-13762	212	25	findings	finding	NOUN
aiua-13762	212	26	of	of	ADP
aiua-13762	212	27	haraldsdottir	haraldsdottir	NOUN
aiua-13762	212	28	,	,	PUNCT
aiua-13762	212	29	despite	despite	SCONJ
aiua-13762	212	30	his	his	PRON
aiua-13762	212	31	study	study	NOUN
aiua-13762	212	32	being	be	AUX
aiua-13762	212	33	excluded	exclude	VERB
aiua-13762	212	34	from	from	ADP
aiua-13762	212	35	the	the	DET
aiua-13762	212	36	meta	meta	NOUN
aiua-13762	212	37	-	-	PUNCT
aiua-13762	212	38	analysis	analysis	NOUN
aiua-13762	212	39	.	.	PUNCT
aiua-13762	213	1	the	the	DET
aiua-13762	213	2	meta	meta	ADJ
aiua-13762	213	3	-	-	PUNCT
aiua-13762	213	4	analysis	analysis	NOUN
aiua-13762	213	5	revealed	reveal	VERB
aiua-13762	213	6	a	a	DET
aiua-13762	213	7	2.13	2.13	NUM
aiua-13762	213	8	-	-	ADJ
aiua-13762	213	9	fold	fold	ADJ
aiua-13762	213	10	increased	increase	VERB
aiua-13762	213	11	risk	risk	NOUN
aiua-13762	213	12	of	of	ADP
aiua-13762	213	13	prostate	prostate	NOUN
aiua-13762	213	14	cancer	cancer	NOUN
aiua-13762	213	15	in	in	ADP
aiua-13762	213	16	mutation	mutation	NOUN
aiua-13762	213	17	carriers	carrier	NOUN
aiua-13762	213	18	from	from	ADP
aiua-13762	213	19	clinic	clinic	NOUN
aiua-13762	213	20	-	-	PUNCT
aiua-13762	213	21	based	base	VERB
aiua-13762	213	22	retrospective	retrospective	ADJ
aiua-13762	213	23	cohorts	cohort	NOUN
aiua-13762	213	24	(	(	PUNCT
aiua-13762	213	25	95	95	NUM
aiua-13762	213	26	%	%	NOUN
aiua-13762	213	27	ci	ci	NOUN
aiua-13762	213	28	,	,	PUNCT
aiua-13762	213	29	1.45	1.45	NUM
aiua-13762	213	30	-	-	SYM
aiua-13762	213	31	2.80	2.80	NUM
aiua-13762	213	32	)	)	PUNCT
aiua-13762	213	33	,	,	PUNCT
aiua-13762	213	34	a	a	DET
aiua-13762	213	35	2.11	2.11	NUM
aiua-13762	213	36	-	-	ADJ
aiua-13762	213	37	fold	fold	ADJ
aiua-13762	213	38	risk	risk	NOUN
aiua-13762	213	39	(	(	PUNCT
aiua-13762	213	40	95	95	NUM
aiua-13762	213	41	%	%	NOUN
aiua-13762	213	42	ci	ci	NOUN
aiua-13762	213	43	,	,	PUNCT
aiua-13762	213	44	1.27	1.27	NUM
aiua-13762	213	45	-	-	SYM
aiua-13762	213	46	2.95	2.95	NUM
aiua-13762	213	47	)	)	PUNCT
aiua-13762	213	48	for	for	ADP
aiua-13762	213	49	male	male	ADJ
aiua-13762	213	50	mutation	mutation	NOUN
aiua-13762	213	51	carriers	carrier	NOUN
aiua-13762	213	52	with	with	ADP
aiua-13762	213	53	a	a	DET
aiua-13762	213	54	prior	prior	ADJ
aiua-13762	213	55	diagnosis	diagnosis	NOUN
aiua-13762	213	56	of	of	ADP
aiua-13762	213	57	colorectal	colorectal	ADJ
aiua-13762	213	58	cancer	cancer	NOUN
aiua-13762	213	59	,	,	PUNCT
aiua-13762	213	60	and	and	CCONJ
aiua-13762	213	61	a	a	DET
aiua-13762	213	62	2.28	2.28	NUM
aiua-13762	213	63	-	-	ADJ
aiua-13762	213	64	fold	fold	ADJ
aiua-13762	213	65	risk	risk	NOUN
aiua-13762	213	66	(	(	PUNCT
aiua-13762	213	67	95	95	NUM
aiua-13762	213	68	%	%	NOUN
aiua-13762	213	69	ci	ci	NOUN
aiua-13762	213	70	,	,	PUNCT
aiua-13762	213	71	1.37	1.37	NUM
aiua-13762	213	72	-	-	SYM
aiua-13762	213	73	3.19	3.19	NUM
aiua-13762	213	74	)	)	PUNCT
aiua-13762	213	75	for	for	ADP
aiua-13762	213	76	men	man	NOUN
aiua-13762	213	77	from	from	ADP
aiua-13762	213	78	mutation	mutation	NOUN
aiua-13762	213	79	-	-	PUNCT
aiua-13762	213	80	carrying	carry	VERB
aiua-13762	213	81	families	family	NOUN
aiua-13762	213	82	,	,	PUNCT
aiua-13762	213	83	when	when	SCONJ
aiua-13762	213	84	compared	compare	VERB
aiua-13762	213	85	to	to	ADP
aiua-13762	213	86	archivio	archivio	NOUN
aiua-13762	213	87	italiano	italiano	X
aiua-13762	213	88	di	di	X
aiua-13762	213	89	urologia	urologia	PROPN
aiua-13762	213	90	e	e	PROPN
aiua-13762	213	91	andrologia	andrologia	NOUN
aiua-13762	213	92	2025	2025	NUM
aiua-13762	213	93	;	;	PUNCT
aiua-13762	213	94	97(2):13762	97(2):13762	NUM
aiua-13762	213	95	7	7	NUM
aiua-13762	213	96	genetic	genetic	ADJ
aiua-13762	213	97	of	of	ADP
aiua-13762	213	98	prostate	prostate	NOUN
aiua-13762	213	99	cancer	cancer	NOUN
aiua-13762	213	100	the	the	DET
aiua-13762	213	101	general	general	ADJ
aiua-13762	213	102	population	population	NOUN
aiua-13762	213	103	(	(	PUNCT
aiua-13762	213	104	85	85	NUM
aiua-13762	213	105	)	)	PUNCT
aiua-13762	213	106	.	.	PUNCT
aiua-13762	214	1	the	the	DET
aiua-13762	214	2	study	study	NOUN
aiua-13762	214	3	also	also	ADV
aiua-13762	214	4	highlighted	highlight	VERB
aiua-13762	214	5	variations	variation	NOUN
aiua-13762	214	6	in	in	ADP
aiua-13762	214	7	prostate	prostate	NOUN
aiua-13762	214	8	cancer	cancer	NOUN
aiua-13762	214	9	risk	risk	NOUN
aiua-13762	214	10	,	,	PUNCT
aiua-13762	214	11	with	with	ADP
aiua-13762	214	12	msh2	msh2	NOUN
aiua-13762	214	13	mutation	mutation	NOUN
aiua-13762	214	14	carriers	carrier	NOUN
aiua-13762	214	15	exhibiting	exhibit	VERB
aiua-13762	214	16	a	a	DET
aiua-13762	214	17	higher	high	ADJ
aiua-13762	214	18	frequency	frequency	NOUN
aiua-13762	214	19	of	of	ADP
aiua-13762	214	20	prostate	prostate	NOUN
aiua-13762	214	21	cancer	cancer	NOUN
aiua-13762	214	22	than	than	ADP
aiua-13762	214	23	carriers	carrier	NOUN
aiua-13762	214	24	of	of	ADP
aiua-13762	214	25	other	other	ADJ
aiua-13762	214	26	mmr	mmr	PROPN
aiua-13762	214	27	genes	gene	NOUN
aiua-13762	214	28	.	.	PUNCT
aiua-13762	215	1	despite	despite	SCONJ
aiua-13762	215	2	potential	potential	ADJ
aiua-13762	215	3	recall	recall	NOUN
aiua-13762	215	4	and	and	CCONJ
aiua-13762	215	5	detection	detection	NOUN
aiua-13762	215	6	biases	bias	NOUN
aiua-13762	215	7	associated	associate	VERB
aiua-13762	215	8	with	with	ADP
aiua-13762	215	9	retrospective	retrospective	ADJ
aiua-13762	215	10	studies	study	NOUN
aiua-13762	215	11	,	,	PUNCT
aiua-13762	215	12	the	the	DET
aiua-13762	215	13	authors	author	NOUN
aiua-13762	215	14	concluded	conclude	VERB
aiua-13762	215	15	that	that	SCONJ
aiua-13762	215	16	prostate	prostate	NOUN
aiua-13762	215	17	cancer	cancer	NOUN
aiua-13762	215	18	may	may	AUX
aiua-13762	215	19	be	be	AUX
aiua-13762	215	20	considered	consider	VERB
aiua-13762	215	21	part	part	NOUN
aiua-13762	215	22	of	of	ADP
aiua-13762	215	23	the	the	DET
aiua-13762	215	24	spectrum	spectrum	NOUN
aiua-13762	215	25	of	of	ADP
aiua-13762	215	26	ls	ls	ADJ
aiua-13762	215	27	associated	associated	ADJ
aiua-13762	215	28	neoplasms	neoplasm	NOUN
aiua-13762	215	29	.	.	PUNCT
aiua-13762	216	1	to	to	ADP
aiua-13762	216	2	date	date	NOUN
aiua-13762	216	3	,	,	PUNCT
aiua-13762	216	4	three	three	NUM
aiua-13762	216	5	founder	founder	NOUN
aiua-13762	216	6	mutations	mutation	NOUN
aiua-13762	216	7	linked	link	VERB
aiua-13762	216	8	to	to	ADP
aiua-13762	216	9	ls	ls	PROPN
aiua-13762	216	10	have	have	AUX
aiua-13762	216	11	been	be	AUX
aiua-13762	216	12	identified	identify	VERB
aiua-13762	216	13	in	in	ADP
aiua-13762	216	14	the	the	DET
aiua-13762	216	15	ashkenazi	ashkenazi	ADJ
aiua-13762	216	16	jewish	jewish	ADJ
aiua-13762	216	17	population	population	NOUN
aiua-13762	216	18	.	.	PUNCT
aiua-13762	217	1	foulkes	foulkes	PROPN
aiua-13762	217	2	et	et	PROPN
aiua-13762	217	3	al	al	PROPN
aiua-13762	217	4	.	.	PROPN
aiua-13762	218	1	characterized	characterize	VERB
aiua-13762	218	2	the	the	DET
aiua-13762	218	3	c.1906g	c.1906g	PROPN
aiua-13762	218	4	>	>	X
aiua-13762	218	5	c	c	X
aiua-13762	218	6	(	(	PUNCT
aiua-13762	218	7	ala636pro	ala636pro	ADJ
aiua-13762	218	8	)	)	PUNCT
aiua-13762	218	9	mutation	mutation	NOUN
aiua-13762	218	10	in	in	ADP
aiua-13762	218	11	msh2	msh2	PROPN
aiua-13762	218	12	,	,	PUNCT
aiua-13762	218	13	which	which	PRON
aiua-13762	218	14	has	have	VERB
aiua-13762	218	15	a	a	DET
aiua-13762	218	16	prevalence	prevalence	NOUN
aiua-13762	218	17	of	of	ADP
aiua-13762	218	18	0.6	0.6	NUM
aiua-13762	218	19	%	%	NOUN
aiua-13762	218	20	among	among	ADP
aiua-13762	218	21	aj	aj	PROPN
aiua-13762	218	22	with	with	ADP
aiua-13762	218	23	colorectal	colorectal	ADJ
aiua-13762	218	24	cancer	cancer	NOUN
aiua-13762	218	25	(	(	PUNCT
aiua-13762	218	26	86	86	NUM
aiua-13762	218	27	)	)	PUNCT
aiua-13762	218	28	.	.	PUNCT
aiua-13762	219	1	additionally	additionally	ADV
aiua-13762	219	2	,	,	PUNCT
aiua-13762	219	3	the	the	DET
aiua-13762	219	4	founder	founder	NOUN
aiua-13762	219	5	truncating	truncate	VERB
aiua-13762	219	6	mutations	mutation	NOUN
aiua-13762	219	7	c.3984_3987dup	c.3984_3987dup	NOUN
aiua-13762	219	8	-	-	PUNCT
aiua-13762	219	9	gtca	gtca	NOUN
aiua-13762	219	10	(	(	PUNCT
aiua-13762	219	11	p.leu1330valfsx12	p.leu1330valfsx12	NOUN
aiua-13762	219	12	)	)	PUNCT
aiua-13762	219	13	and	and	CCONJ
aiua-13762	219	14	c.3959_3962delcaag	c.3959_3962delcaag	VERB
aiua-13762	219	15	in	in	ADP
aiua-13762	219	16	the	the	DET
aiua-13762	219	17	msh6	msh6	NOUN
aiua-13762	219	18	gene	gene	NOUN
aiua-13762	219	19	have	have	AUX
aiua-13762	219	20	been	be	AUX
aiua-13762	219	21	identified	identify	VERB
aiua-13762	219	22	in	in	ADP
aiua-13762	219	23	ashkenazi	ashkenazi	ADJ
aiua-13762	219	24	populations	population	NOUN
aiua-13762	219	25	(	(	PUNCT
aiua-13762	219	26	87,88	87,88	NUM
aiua-13762	219	27	)	)	PUNCT
aiua-13762	219	28	.	.	PUNCT
aiua-13762	220	1	recombination	recombination	NOUN
aiua-13762	220	2	analysis	analysis	NOUN
aiua-13762	220	3	suggests	suggest	VERB
aiua-13762	220	4	that	that	SCONJ
aiua-13762	220	5	both	both	DET
aiua-13762	220	6	mutations	mutation	NOUN
aiua-13762	220	7	likely	likely	ADV
aiua-13762	220	8	originated	originate	VERB
aiua-13762	220	9	in	in	ADP
aiua-13762	220	10	the	the	DET
aiua-13762	220	11	6th	6th	ADJ
aiua-13762	220	12	and	and	CCONJ
aiua-13762	220	13	7th	7th	ADJ
aiua-13762	220	14	centuries	century	NOUN
aiua-13762	220	15	c.e	c.e	PROPN
aiua-13762	220	16	.	.	PROPN
aiua-13762	220	17	,	,	PUNCT
aiua-13762	220	18	respectively	respectively	ADV
aiua-13762	220	19	,	,	PUNCT
aiua-13762	220	20	during	during	ADP
aiua-13762	220	21	the	the	DET
aiua-13762	220	22	early	early	ADJ
aiua-13762	220	23	formation	formation	NOUN
aiua-13762	220	24	of	of	ADP
aiua-13762	220	25	the	the	DET
aiua-13762	220	26	ashkenazi	ashkenazi	ADJ
aiua-13762	220	27	population	population	NOUN
aiua-13762	220	28	in	in	ADP
aiua-13762	220	29	the	the	DET
aiua-13762	220	30	rhineland	rhineland	PROPN
aiua-13762	220	31	through	through	ADP
aiua-13762	220	32	a	a	DET
aiua-13762	220	33	trickle	trickle	NOUN
aiua-13762	220	34	of	of	ADP
aiua-13762	220	35	immigration	immigration	NOUN
aiua-13762	220	36	from	from	ADP
aiua-13762	220	37	the	the	DET
aiua-13762	220	38	south	south	NOUN
aiua-13762	220	39	(	(	PUNCT
aiua-13762	220	40	87	87	NUM
aiua-13762	220	41	,	,	PUNCT
aiua-13762	220	42	12	12	NUM
aiua-13762	220	43	)	)	PUNCT
aiua-13762	220	44	.	.	PUNCT
aiua-13762	221	1	goldberg	goldberg	PROPN
aiua-13762	221	2	and	and	CCONJ
aiua-13762	221	3	colleagues	colleague	NOUN
aiua-13762	221	4	reported	report	VERB
aiua-13762	221	5	that	that	SCONJ
aiua-13762	221	6	while	while	SCONJ
aiua-13762	221	7	mutations	mutation	NOUN
aiua-13762	221	8	in	in	ADP
aiua-13762	221	9	msh2	msh2	NOUN
aiua-13762	221	10	and	and	CCONJ
aiua-13762	221	11	msh6	msh6	NOUN
aiua-13762	221	12	are	be	AUX
aiua-13762	221	13	found	find	VERB
aiua-13762	221	14	in	in	ADP
aiua-13762	221	15	38	38	NUM
aiua-13762	221	16	%	%	NOUN
aiua-13762	221	17	and	and	CCONJ
aiua-13762	221	18	14	14	NUM
aiua-13762	221	19	%	%	NOUN
aiua-13762	221	20	of	of	ADP
aiua-13762	221	21	ls	ls	ADJ
aiua-13762	221	22	patients	patient	NOUN
aiua-13762	221	23	in	in	ADP
aiua-13762	221	24	the	the	DET
aiua-13762	221	25	general	general	ADJ
aiua-13762	221	26	population	population	NOUN
aiua-13762	221	27	,	,	PUNCT
aiua-13762	221	28	the	the	DET
aiua-13762	221	29	frequencies	frequency	NOUN
aiua-13762	221	30	among	among	ADP
aiua-13762	221	31	ashkenazim	ashkenazim	PROPN
aiua-13762	221	32	are	be	AUX
aiua-13762	221	33	74	74	NUM
aiua-13762	221	34	%	%	NOUN
aiua-13762	221	35	and	and	CCONJ
aiua-13762	221	36	18	18	NUM
aiua-13762	221	37	%	%	NOUN
aiua-13762	221	38	,	,	PUNCT
aiua-13762	221	39	respectively	respectively	ADV
aiua-13762	221	40	(	(	PUNCT
aiua-13762	221	41	88	88	NUM
aiua-13762	221	42	)	)	PUNCT
aiua-13762	221	43	.	.	PUNCT
aiua-13762	222	1	importantly	importantly	ADV
aiua-13762	222	2	,	,	PUNCT
aiua-13762	222	3	co	co	NOUN
aiua-13762	222	4	-	-	NOUN
aiua-13762	222	5	inheritance	inheritance	NOUN
aiua-13762	222	6	of	of	ADP
aiua-13762	222	7	brca	brca	PROPN
aiua-13762	222	8	mutations	mutation	NOUN
aiua-13762	222	9	and	and	CCONJ
aiua-13762	222	10	mmr	mmr	PROPN
aiua-13762	222	11	gene	gene	NOUN
aiua-13762	222	12	mutations	mutation	NOUN
aiua-13762	222	13	linked	link	VERB
aiua-13762	222	14	to	to	ADP
aiua-13762	222	15	lynch	lynch	PROPN
aiua-13762	222	16	syndrome	syndrome	PROPN
aiua-13762	222	17	has	have	AUX
aiua-13762	222	18	been	be	AUX
aiua-13762	222	19	reported	report	VERB
aiua-13762	222	20	in	in	ADP
aiua-13762	222	21	several	several	ADJ
aiua-13762	222	22	studies	study	NOUN
aiua-13762	222	23	(	(	PUNCT
aiua-13762	222	24	reviewed	review	VERB
aiua-13762	222	25	in	in	ADP
aiua-13762	222	26	:	:	PUNCT
aiua-13762	222	27	88	88	NUM
aiua-13762	222	28	)	)	PUNCT
aiua-13762	222	29	.	.	PUNCT
aiua-13762	223	1	for	for	ADP
aiua-13762	223	2	instance	instance	NOUN
aiua-13762	223	3	,	,	PUNCT
aiua-13762	223	4	a	a	DET
aiua-13762	223	5	study	study	NOUN
aiua-13762	223	6	by	by	ADP
aiua-13762	223	7	laish	laish	PROPN
aiua-13762	223	8	and	and	CCONJ
aiua-13762	223	9	colleagues	colleague	NOUN
aiua-13762	223	10	identified	identify	VERB
aiua-13762	223	11	eleven	eleven	NUM
aiua-13762	223	12	double	double	ADJ
aiua-13762	223	13	-	-	PUNCT
aiua-13762	223	14	heterozygote	heterozygote	NOUN
aiua-13762	223	15	mutation	mutation	NOUN
aiua-13762	223	16	carriers	carrier	NOUN
aiua-13762	223	17	in	in	ADP
aiua-13762	223	18	four	four	NUM
aiua-13762	223	19	unrelated	unrelated	ADJ
aiua-13762	223	20	israeli	israeli	ADJ
aiua-13762	223	21	ashkenazi	ashkenazi	ADJ
aiua-13762	223	22	families	family	NOUN
aiua-13762	223	23	.	.	PUNCT
aiua-13762	224	1	all	all	DET
aiua-13762	224	2	carriers	carrier	NOUN
aiua-13762	224	3	had	have	VERB
aiua-13762	224	4	a	a	DET
aiua-13762	224	5	brca	brca	PROPN
aiua-13762	224	6	founder	founder	NOUN
aiua-13762	224	7	mutation	mutation	NOUN
aiua-13762	224	8	(	(	PUNCT
aiua-13762	224	9	brca2	brca2	NOUN
aiua-13762	224	10	5946delt	5946delt	NUM
aiua-13762	224	11	/	/	SYM
aiua-13762	224	12	c.6174delt	c.6174delt	NOUN
aiua-13762	224	13	,	,	PUNCT
aiua-13762	224	14	n	n	NOUN
aiua-13762	224	15	=	=	SYM
aiua-13762	224	16	10	10	NUM
aiua-13762	224	17	;	;	PUNCT
aiua-13762	224	18	brca1	brca1	PROPN
aiua-13762	224	19	185delag	185delag	PROPN
aiua-13762	224	20	,	,	PUNCT
aiua-13762	224	21	n	n	NOUN
aiua-13762	224	22	=	=	SYM
aiua-13762	224	23	1	1	NUM
aiua-13762	224	24	)	)	PUNCT
aiua-13762	224	25	and	and	CCONJ
aiua-13762	224	26	an	an	DET
aiua-13762	224	27	mmr	mmr	PROPN
aiua-13762	224	28	aj	aj	PROPN
aiua-13762	224	29	founder	founder	PROPN
aiua-13762	224	30	mutation	mutation	NOUN
aiua-13762	224	31	(	(	PUNCT
aiua-13762	224	32	msh2	msh2	PROPN
aiua-13762	224	33	1906g	1906g	NUM
aiua-13762	224	34	>	>	X
aiua-13762	224	35	c	c	X
aiua-13762	224	36	,	,	PUNCT
aiua-13762	224	37	msh6	msh6	NOUN
aiua-13762	224	38	3984_3987dupgtca	3984_3987dupgtca	NUM
aiua-13762	224	39	,	,	PUNCT
aiua-13762	224	40	or	or	CCONJ
aiua-13762	224	41	msh6	msh6	VERB
aiua-13762	224	42	3956_3957duppv	3956_3957duppv	NOUN
aiua-13762	224	43	)	)	PUNCT
aiua-13762	224	44	.	.	PUNCT
aiua-13762	225	1	among	among	ADP
aiua-13762	225	2	these	these	DET
aiua-13762	225	3	carriers	carrier	NOUN
aiua-13762	225	4	,	,	PUNCT
aiua-13762	225	5	one	one	NUM
aiua-13762	225	6	patient	patient	NOUN
aiua-13762	225	7	was	be	AUX
aiua-13762	225	8	diagnosed	diagnose	VERB
aiua-13762	225	9	with	with	ADP
aiua-13762	225	10	prostate	prostate	NOUN
aiua-13762	225	11	cancer	cancer	NOUN
aiua-13762	225	12	(	(	PUNCT
aiua-13762	225	13	89	89	NUM
aiua-13762	225	14	)	)	PUNCT
aiua-13762	225	15	.	.	PUNCT
aiua-13762	226	1	further	further	ADJ
aiua-13762	226	2	studies	study	NOUN
aiua-13762	226	3	are	be	AUX
aiua-13762	226	4	required	require	VERB
aiua-13762	226	5	to	to	PART
aiua-13762	226	6	evaluate	evaluate	VERB
aiua-13762	226	7	whether	whether	SCONJ
aiua-13762	226	8	the	the	DET
aiua-13762	226	9	simultaneous	simultaneous	ADJ
aiua-13762	226	10	presence	presence	NOUN
aiua-13762	226	11	of	of	ADP
aiua-13762	226	12	brca1	brca1	PROPN
aiua-13762	226	13	/	/	SYM
aiua-13762	226	14	brca2	brca2	PROPN
aiua-13762	226	15	founder	founder	NOUN
aiua-13762	226	16	mutations	mutation	NOUN
aiua-13762	226	17	and	and	CCONJ
aiua-13762	226	18	lynch	lynch	NOUN
aiua-13762	226	19	-	-	PUNCT
aiua-13762	226	20	linked	link	VERB
aiua-13762	226	21	mmr	mmr	PROPN
aiua-13762	226	22	mutations	mutation	NOUN
aiua-13762	226	23	exerts	exert	VERB
aiua-13762	226	24	a	a	DET
aiua-13762	226	25	deleterious	deleterious	ADJ
aiua-13762	226	26	effect	effect	NOUN
aiua-13762	226	27	in	in	ADP
aiua-13762	226	28	the	the	DET
aiua-13762	226	29	ashkenazi	ashkenazi	ADJ
aiua-13762	226	30	jewish	jewish	ADJ
aiua-13762	226	31	population	population	NOUN
aiua-13762	226	32	.	.	PUNCT
aiua-13762	227	1	germline	germline	NOUN
aiua-13762	227	2	mutations	mutation	NOUN
aiua-13762	227	3	in	in	ADP
aiua-13762	227	4	various	various	ADJ
aiua-13762	227	5	genes	gene	NOUN
aiua-13762	227	6	a	a	DET
aiua-13762	227	7	2008	2008	NUM
aiua-13762	227	8	study	study	NOUN
aiua-13762	227	9	conducted	conduct	VERB
aiua-13762	227	10	in	in	ADP
aiua-13762	227	11	north	north	PROPN
aiua-13762	227	12	america	america	PROPN
aiua-13762	227	13	explored	explore	VERB
aiua-13762	227	14	the	the	DET
aiua-13762	227	15	role	role	NOUN
aiua-13762	227	16	of	of	ADP
aiua-13762	227	17	seven	seven	NUM
aiua-13762	227	18	newly	newly	ADV
aiua-13762	227	19	identified	identify	VERB
aiua-13762	227	20	snps	snps	NOUN
aiua-13762	227	21	in	in	ADP
aiua-13762	227	22	the	the	DET
aiua-13762	227	23	chek2	chek2	NOUN
aiua-13762	227	24	gene	gene	NOUN
aiua-13762	227	25	(	(	PUNCT
aiua-13762	227	26	located	locate	VERB
aiua-13762	227	27	on	on	ADP
aiua-13762	227	28	chromosome	chromosome	NOUN
aiua-13762	227	29	22q	22q	NOUN
aiua-13762	227	30	)	)	PUNCT
aiua-13762	227	31	among	among	ADP
aiua-13762	227	32	aj	aj	PROPN
aiua-13762	227	33	men	man	NOUN
aiua-13762	227	34	with	with	ADP
aiua-13762	227	35	prostate	prostate	NOUN
aiua-13762	227	36	cancer	cancer	NOUN
aiua-13762	227	37	(	(	PUNCT
aiua-13762	227	38	90	90	NUM
aiua-13762	227	39	)	)	PUNCT
aiua-13762	227	40	.	.	PUNCT
aiua-13762	228	1	of	of	ADP
aiua-13762	228	2	these	these	DET
aiua-13762	228	3	snps	snps	NOUN
aiua-13762	228	4	,	,	PUNCT
aiua-13762	228	5	the	the	DET
aiua-13762	228	6	1270t	1270t	NUM
aiua-13762	228	7	>	>	PUNCT
aiua-13762	228	8	c	c	NOUN
aiua-13762	228	9	variant	variant	NOUN
aiua-13762	228	10	in	in	ADP
aiua-13762	228	11	exon	exon	PROPN
aiua-13762	228	12	11	11	NUM
aiua-13762	228	13	,	,	PUNCT
aiua-13762	228	14	which	which	PRON
aiua-13762	228	15	causes	cause	VERB
aiua-13762	228	16	the	the	DET
aiua-13762	228	17	missense	missense	NOUN
aiua-13762	228	18	y242h	y242h	PROPN
aiua-13762	228	19	substitution	substitution	NOUN
aiua-13762	228	20	,	,	PUNCT
aiua-13762	228	21	was	be	AUX
aiua-13762	228	22	identified	identify	VERB
aiua-13762	228	23	in	in	ADP
aiua-13762	228	24	three	three	NUM
aiua-13762	228	25	affected	affected	ADJ
aiua-13762	228	26	men	man	NOUN
aiua-13762	228	27	from	from	ADP
aiua-13762	228	28	one	one	NUM
aiua-13762	228	29	family	family	NOUN
aiua-13762	228	30	and	and	CCONJ
aiua-13762	228	31	four	four	NUM
aiua-13762	228	32	affected	affected	ADJ
aiua-13762	228	33	men	man	NOUN
aiua-13762	228	34	from	from	ADP
aiua-13762	228	35	another	another	PRON
aiua-13762	228	36	.	.	PUNCT
aiua-13762	229	1	however	however	ADV
aiua-13762	229	2	,	,	PUNCT
aiua-13762	229	3	the	the	DET
aiua-13762	229	4	mutation	mutation	NOUN
aiua-13762	229	5	did	do	AUX
aiua-13762	229	6	not	not	PART
aiua-13762	229	7	consistently	consistently	ADV
aiua-13762	229	8	segregate	segregate	VERB
aiua-13762	229	9	with	with	ADP
aiua-13762	229	10	the	the	DET
aiua-13762	229	11	disease	disease	NOUN
aiua-13762	229	12	.	.	PUNCT
aiua-13762	230	1	it	it	PRON
aiua-13762	230	2	was	be	AUX
aiua-13762	230	3	found	find	VERB
aiua-13762	230	4	in	in	ADP
aiua-13762	230	5	4	4	NUM
aiua-13762	230	6	out	out	ADP
aiua-13762	230	7	of	of	ADP
aiua-13762	230	8	85	85	NUM
aiua-13762	230	9	families	family	NOUN
aiua-13762	230	10	with	with	ADP
aiua-13762	230	11	affected	affected	ADJ
aiua-13762	230	12	probands	proband	NOUN
aiua-13762	230	13	,	,	PUNCT
aiua-13762	230	14	but	but	CCONJ
aiua-13762	230	15	in	in	ADP
aiua-13762	230	16	none	none	NOUN
aiua-13762	230	17	of	of	ADP
aiua-13762	230	18	136	136	NUM
aiua-13762	230	19	pca	pca	NOUN
aiua-13762	230	20	cases	case	NOUN
aiua-13762	230	21	from	from	ADP
aiua-13762	230	22	montreal	montreal	PROPN
aiua-13762	230	23	,	,	PUNCT
aiua-13762	230	24	none	none	NOUN
aiua-13762	230	25	of	of	ADP
aiua-13762	230	26	221	221	NUM
aiua-13762	230	27	aj	aj	PROPN
aiua-13762	230	28	controls	control	NOUN
aiua-13762	230	29	,	,	PUNCT
aiua-13762	230	30	and	and	CCONJ
aiua-13762	230	31	in	in	ADP
aiua-13762	230	32	8	8	NUM
aiua-13762	230	33	out	out	ADP
aiua-13762	230	34	of	of	ADP
aiua-13762	230	35	740	740	NUM
aiua-13762	230	36	unselected	unselected	ADJ
aiua-13762	230	37	pca	pca	NOUN
aiua-13762	230	38	cases	case	NOUN
aiua-13762	230	39	.	.	PUNCT
aiua-13762	231	1	the	the	DET
aiua-13762	231	2	authors	author	NOUN
aiua-13762	231	3	concluded	conclude	VERB
aiua-13762	231	4	that	that	SCONJ
aiua-13762	231	5	the	the	DET
aiua-13762	231	6	y242h	y242h	ADJ
aiua-13762	231	7	variant	variant	NOUN
aiua-13762	231	8	is	be	AUX
aiua-13762	231	9	unlikely	unlikely	ADJ
aiua-13762	231	10	to	to	PART
aiua-13762	231	11	play	play	VERB
aiua-13762	231	12	a	a	DET
aiua-13762	231	13	major	major	ADJ
aiua-13762	231	14	role	role	NOUN
aiua-13762	231	15	in	in	ADP
aiua-13762	231	16	pca	pca	NOUN
aiua-13762	231	17	predisposition	predisposition	NOUN
aiua-13762	231	18	,	,	PUNCT
aiua-13762	231	19	though	though	SCONJ
aiua-13762	231	20	it	it	PRON
aiua-13762	231	21	may	may	AUX
aiua-13762	231	22	represent	represent	VERB
aiua-13762	231	23	a	a	DET
aiua-13762	231	24	mild	mild	ADJ
aiua-13762	231	25	predisposition	predisposition	NOUN
aiua-13762	231	26	allele	allele	NOUN
aiua-13762	231	27	in	in	ADP
aiua-13762	231	28	aj	aj	PROPN
aiua-13762	231	29	men	man	NOUN
aiua-13762	231	30	.	.	PUNCT
aiua-13762	232	1	at	at	ADP
aiua-13762	232	2	the	the	DET
aiua-13762	232	3	genetic	genetic	PROPN
aiua-13762	232	4	institute	institute	NOUN
aiua-13762	232	5	of	of	ADP
aiua-13762	232	6	the	the	DET
aiua-13762	232	7	tel	tel	PROPN
aiua-13762	232	8	aviv	aviv	PROPN
aiua-13762	232	9	sourasky	sourasky	PROPN
aiua-13762	232	10	medical	medical	ADJ
aiua-13762	232	11	center	center	NOUN
aiua-13762	232	12	,	,	PUNCT
aiua-13762	232	13	a	a	DET
aiua-13762	232	14	study	study	NOUN
aiua-13762	232	15	screened	screen	VERB
aiua-13762	232	16	188	188	NUM
aiua-13762	232	17	aj	aj	NOUN
aiua-13762	232	18	and	and	CCONJ
aiua-13762	232	19	112	112	NUM
aiua-13762	232	20	non	non	ADJ
aiua-13762	232	21	-	-	ADJ
aiua-13762	232	22	aj	aj	ADJ
aiua-13762	232	23	pca	pca	PROPN
aiua-13762	232	24	patients	patient	NOUN
aiua-13762	232	25	for	for	ADP
aiua-13762	232	26	mutations	mutation	NOUN
aiua-13762	232	27	in	in	ADP
aiua-13762	232	28	three	three	NUM
aiua-13762	232	29	candidate	candidate	NOUN
aiua-13762	232	30	genes	gene	NOUN
aiua-13762	232	31	implicated	implicate	VERB
aiua-13762	232	32	in	in	ADP
aiua-13762	232	33	prostate	prostate	NOUN
aiua-13762	232	34	cancer	cancer	NOUN
aiua-13762	232	35	:	:	PUNCT
aiua-13762	232	36	phosphatase	phosphatase	NOUN
aiua-13762	232	37	and	and	CCONJ
aiua-13762	232	38	tensin	tensin	PROPN
aiua-13762	232	39	homolog	homolog	PROPN
aiua-13762	232	40	(	(	PUNCT
aiua-13762	232	41	pten	pten	NOUN
aiua-13762	232	42	)	)	PUNCT
aiua-13762	232	43	,	,	PUNCT
aiua-13762	232	44	kruppel	kruppel	PROPN
aiua-13762	232	45	-	-	PUNCT
aiua-13762	232	46	like	like	ADJ
aiua-13762	232	47	factor	factor	NOUN
aiua-13762	232	48	6	6	NUM
aiua-13762	232	49	(	(	PUNCT
aiua-13762	232	50	klf6	klf6	PROPN
aiua-13762	232	51	)	)	PUNCT
aiua-13762	232	52	,	,	PUNCT
aiua-13762	232	53	and	and	CCONJ
aiua-13762	232	54	macrophage	macrophage	ADJ
aiua-13762	232	55	scavenger	scavenger	NOUN
aiua-13762	232	56	receptor	receptor	NOUN
aiua-13762	232	57	1	1	NUM
aiua-13762	232	58	(	(	PUNCT
aiua-13762	232	59	msr1	msr1	PROPN
aiua-13762	232	60	)	)	PUNCT
aiua-13762	232	61	(	(	PUNCT
aiua-13762	232	62	91	91	NUM
aiua-13762	232	63	)	)	PUNCT
aiua-13762	232	64	.	.	PUNCT
aiua-13762	233	1	controls	control	NOUN
aiua-13762	233	2	included	include	VERB
aiua-13762	233	3	200	200	NUM
aiua-13762	233	4	healthy	healthy	ADJ
aiua-13762	233	5	aj	aj	PROPN
aiua-13762	233	6	women	woman	NOUN
aiua-13762	233	7	and	and	CCONJ
aiua-13762	233	8	100	100	NUM
aiua-13762	233	9	non	non	ADJ
aiua-13762	233	10	-	-	ADJ
aiua-13762	233	11	aj	aj	ADJ
aiua-13762	233	12	women	woman	NOUN
aiua-13762	233	13	.	.	PUNCT
aiua-13762	234	1	among	among	ADP
aiua-13762	234	2	the	the	DET
aiua-13762	234	3	mutations	mutation	NOUN
aiua-13762	234	4	examined	examine	VERB
aiua-13762	234	5	,	,	PUNCT
aiua-13762	234	6	the	the	DET
aiua-13762	234	7	g160x	g160x	NOUN
aiua-13762	234	8	variant	variant	NOUN
aiua-13762	234	9	(	(	PUNCT
aiua-13762	234	10	478c	478c	PROPN
aiua-13762	234	11	>	>	SYM
aiua-13762	234	12	t	t	PROPN
aiua-13762	234	13	)	)	PUNCT
aiua-13762	234	14	in	in	ADP
aiua-13762	234	15	klf6	klf6	PROPN
aiua-13762	234	16	was	be	AUX
aiua-13762	234	17	found	find	VERB
aiua-13762	234	18	in	in	ADP
aiua-13762	234	19	one	one	NUM
aiua-13762	234	20	pca	pca	NOUN
aiua-13762	234	21	patient	patient	NOUN
aiua-13762	234	22	but	but	CCONJ
aiua-13762	234	23	not	not	PART
aiua-13762	234	24	in	in	ADP
aiua-13762	234	25	any	any	PRON
aiua-13762	234	26	of	of	ADP
aiua-13762	234	27	the	the	DET
aiua-13762	234	28	controls	control	NOUN
aiua-13762	234	29	.	.	PUNCT
aiua-13762	235	1	however	however	ADV
aiua-13762	235	2	,	,	PUNCT
aiua-13762	235	3	the	the	DET
aiua-13762	235	4	premature	premature	ADJ
aiua-13762	235	5	stop	stop	NOUN
aiua-13762	235	6	codon	codon	NOUN
aiua-13762	235	7	generated	generate	VERB
aiua-13762	235	8	by	by	ADP
aiua-13762	235	9	this	this	DET
aiua-13762	235	10	variant	variant	NOUN
aiua-13762	235	11	did	do	AUX
aiua-13762	235	12	not	not	PART
aiua-13762	235	13	result	result	VERB
aiua-13762	235	14	in	in	ADP
aiua-13762	235	15	reduced	reduced	ADJ
aiua-13762	235	16	gene	gene	NOUN
aiua-13762	235	17	expression	expression	NOUN
aiua-13762	235	18	at	at	ADP
aiua-13762	235	19	the	the	DET
aiua-13762	235	20	rna	rna	NOUN
aiua-13762	235	21	level	level	NOUN
aiua-13762	235	22	,	,	PUNCT
aiua-13762	235	23	suggesting	suggest	VERB
aiua-13762	235	24	that	that	SCONJ
aiua-13762	235	25	loss	loss	NOUN
aiua-13762	235	26	of	of	ADP
aiua-13762	235	27	the	the	DET
aiua-13762	235	28	wild	wild	ADJ
aiua-13762	235	29	-	-	PUNCT
aiua-13762	235	30	type	type	NOUN
aiua-13762	235	31	allele	allele	NOUN
aiua-13762	235	32	did	do	AUX
aiua-13762	235	33	not	not	PART
aiua-13762	235	34	occur	occur	VERB
aiua-13762	235	35	in	in	ADP
aiua-13762	235	36	this	this	DET
aiua-13762	235	37	case	case	NOUN
aiua-13762	235	38	.	.	PUNCT
aiua-13762	236	1	interestingly	interestingly	ADV
aiua-13762	236	2	,	,	PUNCT
aiua-13762	236	3	the	the	DET
aiua-13762	236	4	intronic	intronic	ADJ
aiua-13762	236	5	ivs1	ivs1	PROPN
aiua-13762	236	6	-	-	PUNCT
aiua-13762	236	7	27g	27g	NUM
aiua-13762	236	8	>	>	X
aiua-13762	236	9	a	a	DET
aiua-13762	236	10	mutation	mutation	NOUN
aiua-13762	236	11	in	in	ADP
aiua-13762	236	12	klf6	klf6	PROPN
aiua-13762	236	13	,	,	PUNCT
aiua-13762	236	14	which	which	PRON
aiua-13762	236	15	generates	generate	VERB
aiua-13762	236	16	a	a	DET
aiua-13762	236	17	novel	novel	ADJ
aiua-13762	236	18	splice	splice	NOUN
aiua-13762	236	19	variant	variant	NOUN
aiua-13762	236	20	,	,	PUNCT
aiua-13762	236	21	was	be	AUX
aiua-13762	236	22	detected	detect	VERB
aiua-13762	236	23	in	in	ADP
aiua-13762	236	24	a	a	DET
aiua-13762	236	25	significantly	significantly	ADV
aiua-13762	236	26	larger	large	ADJ
aiua-13762	236	27	fraction	fraction	NOUN
aiua-13762	236	28	of	of	ADP
aiua-13762	236	29	controls	control	NOUN
aiua-13762	236	30	(	(	PUNCT
aiua-13762	236	31	17.3	17.3	NUM
aiua-13762	236	32	%	%	NOUN
aiua-13762	236	33	)	)	PUNCT
aiua-13762	236	34	than	than	ADP
aiua-13762	236	35	in	in	ADP
aiua-13762	236	36	pca	pca	NOUN
aiua-13762	236	37	patients	patient	NOUN
aiua-13762	236	38	(	(	PUNCT
aiua-13762	236	39	11.9	11.9	NUM
aiua-13762	236	40	%	%	NOUN
aiua-13762	236	41	,	,	PUNCT
aiua-13762	236	42	p	p	X
aiua-13762	236	43	=	=	NOUN
aiua-13762	236	44	0.043	0.043	NUM
aiua-13762	236	45	)	)	PUNCT
aiua-13762	236	46	.	.	PUNCT
aiua-13762	237	1	additionally	additionally	ADV
aiua-13762	237	2	,	,	PUNCT
aiua-13762	237	3	the	the	DET
aiua-13762	237	4	ivs1	ivs1	NOUN
aiua-13762	237	5	-	-	PUNCT
aiua-13762	237	6	27a	27a	NOUN
aiua-13762	237	7	allele	allele	NOUN
aiua-13762	237	8	was	be	AUX
aiua-13762	237	9	significantly	significantly	ADV
aiua-13762	237	10	less	less	ADV
aiua-13762	237	11	frequent	frequent	ADJ
aiua-13762	237	12	in	in	ADP
aiua-13762	237	13	aj	aj	PROPN
aiua-13762	237	14	pca	pca	PROPN
aiua-13762	237	15	patients	patient	NOUN
aiua-13762	237	16	compared	compare	VERB
aiua-13762	237	17	to	to	ADP
aiua-13762	237	18	aj	aj	PROPN
aiua-13762	237	19	controls	controls	PROPN
aiua-13762	237	20	(	(	PUNCT
aiua-13762	237	21	5.6	5.6	NUM
aiua-13762	237	22	%	%	NOUN
aiua-13762	237	23	vs.	vs.	ADP
aiua-13762	237	24	9	9	NUM
aiua-13762	237	25	%	%	NOUN
aiua-13762	237	26	,	,	PUNCT
aiua-13762	237	27	respectively	respectively	ADV
aiua-13762	237	28	,	,	PUNCT
aiua-13762	237	29	p	p	X
aiua-13762	237	30	=	=	NOUN
aiua-13762	237	31	0.047	0.047	NUM
aiua-13762	237	32	)	)	PUNCT
aiua-13762	237	33	,	,	PUNCT
aiua-13762	237	34	and	and	CCONJ
aiua-13762	237	35	was	be	AUX
aiua-13762	237	36	also	also	ADV
aiua-13762	237	37	significantly	significantly	ADV
aiua-13762	237	38	less	less	ADV
aiua-13762	237	39	present	present	ADJ
aiua-13762	237	40	in	in	ADP
aiua-13762	237	41	all	all	DET
aiua-13762	237	42	pca	pca	NOUN
aiua-13762	237	43	patients	patient	NOUN
aiua-13762	237	44	compared	compare	VERB
aiua-13762	237	45	to	to	ADP
aiua-13762	237	46	all	all	DET
aiua-13762	237	47	controls	control	NOUN
aiua-13762	237	48	(	(	PUNCT
aiua-13762	237	49	6.1	6.1	NUM
aiua-13762	237	50	%	%	NOUN
aiua-13762	237	51	vs.	vs.	ADP
aiua-13762	237	52	9.2	9.2	NUM
aiua-13762	237	53	%	%	NOUN
aiua-13762	237	54	,	,	PUNCT
aiua-13762	237	55	respectively	respectively	ADV
aiua-13762	237	56	,	,	PUNCT
aiua-13762	237	57	p	p	X
aiua-13762	237	58	=	=	NOUN
aiua-13762	237	59	0.03	0.03	NUM
aiua-13762	237	60	)	)	PUNCT
aiua-13762	237	61	.	.	PUNCT
aiua-13762	238	1	the	the	DET
aiua-13762	238	2	authors	author	NOUN
aiua-13762	238	3	concluded	conclude	VERB
aiua-13762	238	4	that	that	SCONJ
aiua-13762	238	5	the	the	DET
aiua-13762	238	6	negative	negative	ADJ
aiua-13762	238	7	association	association	NOUN
aiua-13762	238	8	between	between	ADP
aiua-13762	238	9	the	the	DET
aiua-13762	238	10	ivs1	ivs1	PROPN
aiua-13762	238	11	-	-	PUNCT
aiua-13762	238	12	27a	27a	NOUN
aiua-13762	238	13	allele	allele	NOUN
aiua-13762	238	14	and	and	CCONJ
aiua-13762	238	15	pca	pca	NOUN
aiua-13762	238	16	risk	risk	NOUN
aiua-13762	238	17	may	may	AUX
aiua-13762	238	18	be	be	AUX
aiua-13762	238	19	attributed	attribute	VERB
aiua-13762	238	20	to	to	ADP
aiua-13762	238	21	its	its	PRON
aiua-13762	238	22	significantly	significantly	ADV
aiua-13762	238	23	lower	low	ADJ
aiua-13762	238	24	frequency	frequency	NOUN
aiua-13762	238	25	in	in	ADP
aiua-13762	238	26	aj	aj	PROPN
aiua-13762	238	27	patients	patient	NOUN
aiua-13762	238	28	.	.	PUNCT
aiua-13762	239	1	protection	protection	NOUN
aiua-13762	239	2	of	of	ADP
aiua-13762	239	3	telomeres	telomere	NOUN
aiua-13762	239	4	1	1	NUM
aiua-13762	239	5	(	(	PUNCT
aiua-13762	239	6	pot1	pot1	PROPN
aiua-13762	239	7	)	)	PUNCT
aiua-13762	239	8	is	be	AUX
aiua-13762	239	9	a	a	DET
aiua-13762	239	10	component	component	NOUN
aiua-13762	239	11	of	of	ADP
aiua-13762	239	12	the	the	DET
aiua-13762	239	13	six	six	NUM
aiua-13762	239	14	-	-	PUNCT
aiua-13762	239	15	membered	membere	VERB
aiua-13762	239	16	shelterin	shelterin	NOUN
aiua-13762	239	17	complex	complex	NOUN
aiua-13762	239	18	that	that	PRON
aiua-13762	239	19	plays	play	VERB
aiua-13762	239	20	a	a	DET
aiua-13762	239	21	critical	critical	ADJ
aiua-13762	239	22	role	role	NOUN
aiua-13762	239	23	in	in	ADP
aiua-13762	239	24	telomere	telomere	NOUN
aiua-13762	239	25	length	length	NOUN
aiua-13762	239	26	regulation	regulation	NOUN
aiua-13762	239	27	and	and	CCONJ
aiua-13762	239	28	protection	protection	NOUN
aiua-13762	239	29	.	.	PUNCT
aiua-13762	240	1	the	the	DET
aiua-13762	240	2	p.(i78	p.(i78	PROPN
aiua-13762	240	3	t	t	PROPN
aiua-13762	240	4	)	)	PUNCT
aiua-13762	240	5	variant	variant	NOUN
aiua-13762	240	6	in	in	ADP
aiua-13762	240	7	pot1	pot1	PROPN
aiua-13762	240	8	has	have	AUX
aiua-13762	240	9	been	be	AUX
aiua-13762	240	10	identified	identify	VERB
aiua-13762	240	11	as	as	ADP
aiua-13762	240	12	a	a	DET
aiua-13762	240	13	founder	founder	NOUN
aiua-13762	240	14	pathogenic	pathogenic	ADJ
aiua-13762	240	15	mutation	mutation	NOUN
aiua-13762	240	16	in	in	ADP
aiua-13762	240	17	aj	aj	PROPN
aiua-13762	240	18	.	.	PUNCT
aiua-13762	241	1	a	a	DET
aiua-13762	241	2	2024	2024	NUM
aiua-13762	241	3	database	database	NOUN
aiua-13762	241	4	review	review	NOUN
aiua-13762	241	5	detected	detect	VERB
aiua-13762	241	6	cases	case	NOUN
aiua-13762	241	7	of	of	ADP
aiua-13762	241	8	pca	pca	NOUN
aiua-13762	241	9	among	among	ADP
aiua-13762	241	10	carriers	carrier	NOUN
aiua-13762	241	11	and	and	CCONJ
aiua-13762	241	12	advocated	advocate	VERB
aiua-13762	241	13	for	for	ADP
aiua-13762	241	14	the	the	DET
aiua-13762	241	15	inclusion	inclusion	NOUN
aiua-13762	241	16	of	of	ADP
aiua-13762	241	17	pot1	pot1	PROPN
aiua-13762	241	18	in	in	ADP
aiua-13762	241	19	germline	germline	NOUN
aiua-13762	241	20	screening	screen	VERB
aiua-13762	241	21	panels	panel	NOUN
aiua-13762	241	22	for	for	ADP
aiua-13762	241	23	cancer	cancer	NOUN
aiua-13762	241	24	(	(	PUNCT
aiua-13762	241	25	92	92	NUM
aiua-13762	241	26	)	)	PUNCT
aiua-13762	241	27	.	.	PUNCT
aiua-13762	242	1	extensive	extensive	ADJ
aiua-13762	242	2	studies	study	NOUN
aiua-13762	242	3	are	be	AUX
aiua-13762	242	4	required	require	VERB
aiua-13762	242	5	to	to	PART
aiua-13762	242	6	further	far	ADV
aiua-13762	242	7	elucidate	elucidate	VERB
aiua-13762	242	8	the	the	DET
aiua-13762	242	9	pathogenic	pathogenic	ADJ
aiua-13762	242	10	role	role	NOUN
aiua-13762	242	11	of	of	ADP
aiua-13762	242	12	pot1	pot1	PROPN
aiua-13762	242	13	mutations	mutation	NOUN
aiua-13762	242	14	in	in	ADP
aiua-13762	242	15	pca	pca	PROPN
aiua-13762	242	16	among	among	ADP
aiua-13762	242	17	ashkenazim	ashkenazim	PROPN
aiua-13762	242	18	.	.	PUNCT
aiua-13762	243	1	genetic	genetic	ADJ
aiua-13762	243	2	screening	screening	NOUN
aiua-13762	243	3	,	,	PUNCT
aiua-13762	243	4	diagnosis	diagnosis	NOUN
aiua-13762	243	5	and	and	CCONJ
aiua-13762	243	6	counseling	counsel	VERB
aiua-13762	243	7	genetic	genetic	ADJ
aiua-13762	243	8	screening	screening	NOUN
aiua-13762	243	9	while	while	SCONJ
aiua-13762	243	10	the	the	DET
aiua-13762	243	11	role	role	NOUN
aiua-13762	243	12	of	of	ADP
aiua-13762	243	13	certain	certain	ADJ
aiua-13762	243	14	genetic	genetic	ADJ
aiua-13762	243	15	determinants	determinant	NOUN
aiua-13762	243	16	of	of	ADP
aiua-13762	243	17	pca	pca	PROPN
aiua-13762	243	18	in	in	ADP
aiua-13762	243	19	aj	aj	PROPN
aiua-13762	243	20	still	still	ADV
aiua-13762	243	21	remains	remain	VERB
aiua-13762	243	22	to	to	PART
aiua-13762	243	23	be	be	AUX
aiua-13762	243	24	fully	fully	ADV
aiua-13762	243	25	confirmed	confirm	VERB
aiua-13762	243	26	,	,	PUNCT
aiua-13762	243	27	ashkenazi	ashkenazi	ADJ
aiua-13762	243	28	ancestry	ancestry	NOUN
aiua-13762	243	29	is	be	AUX
aiua-13762	243	30	included	include	VERB
aiua-13762	243	31	among	among	ADP
aiua-13762	243	32	the	the	DET
aiua-13762	243	33	eligibility	eligibility	NOUN
aiua-13762	243	34	criteria	criterion	NOUN
aiua-13762	243	35	for	for	ADP
aiua-13762	243	36	germline	germline	NOUN
aiua-13762	243	37	testing	testing	NOUN
aiua-13762	243	38	in	in	ADP
aiua-13762	243	39	the	the	DET
aiua-13762	243	40	framework	framework	NOUN
aiua-13762	243	41	for	for	ADP
aiua-13762	243	42	prostate	prostate	NOUN
aiua-13762	243	43	cancer	cancer	NOUN
aiua-13762	243	44	genetic	genetic	ADJ
aiua-13762	243	45	evaluation	evaluation	NOUN
aiua-13762	243	46	and	and	CCONJ
aiua-13762	243	47	management	management	NOUN
aiua-13762	243	48	algorithm	algorithm	NOUN
aiua-13762	243	49	established	establish	VERB
aiua-13762	243	50	at	at	ADP
aiua-13762	243	51	the	the	DET
aiua-13762	243	52	2019	2019	NUM
aiua-13762	243	53	philadelphia	philadelphia	PROPN
aiua-13762	243	54	prostate	prostate	NOUN
aiua-13762	243	55	cancer	cancer	NOUN
aiua-13762	243	56	consensus	consensus	NOUN
aiua-13762	243	57	conference	conference	NOUN
aiua-13762	243	58	.	.	PUNCT
aiua-13762	244	1	key	key	ADJ
aiua-13762	244	2	eligibility	eligibility	NOUN
aiua-13762	244	3	criteria	criterion	NOUN
aiua-13762	244	4	also	also	ADV
aiua-13762	244	5	include	include	VERB
aiua-13762	244	6	a	a	DET
aiua-13762	244	7	strong	strong	ADJ
aiua-13762	244	8	family	family	NOUN
aiua-13762	244	9	history	history	NOUN
aiua-13762	244	10	(	(	PUNCT
aiua-13762	244	11	two	two	NUM
aiua-13762	244	12	or	or	CCONJ
aiua-13762	244	13	more	more	ADJ
aiua-13762	244	14	male	male	ADJ
aiua-13762	244	15	relatives	relative	NOUN
aiua-13762	244	16	diagnosed	diagnose	VERB
aiua-13762	244	17	with	with	ADP
aiua-13762	244	18	pca	pca	PROPN
aiua-13762	244	19	before	before	ADP
aiua-13762	244	20	age	age	NOUN
aiua-13762	244	21	60	60	NUM
aiua-13762	244	22	or	or	CCONJ
aiua-13762	244	23	who	who	PRON
aiua-13762	244	24	died	die	VERB
aiua-13762	244	25	from	from	ADP
aiua-13762	244	26	it	it	PRON
aiua-13762	244	27	)	)	PUNCT
aiua-13762	244	28	,	,	PUNCT
aiua-13762	244	29	specific	specific	ADJ
aiua-13762	244	30	pathological	pathological	ADJ
aiua-13762	244	31	features	feature	NOUN
aiua-13762	244	32	(	(	PUNCT
aiua-13762	244	33	e.g.	e.g.	ADV
aiua-13762	244	34	,	,	PUNCT
aiua-13762	244	35	intraductal	intraductal	ADJ
aiua-13762	244	36	pathology	pathology	NOUN
aiua-13762	244	37	or	or	CCONJ
aiua-13762	244	38	advanced	advanced	ADJ
aiua-13762	244	39	disease	disease	NOUN
aiua-13762	244	40	)	)	PUNCT
aiua-13762	244	41	,	,	PUNCT
aiua-13762	244	42	ashkenazi	ashkenazi	ADJ
aiua-13762	244	43	ethnicity	ethnicity	NOUN
aiua-13762	244	44	,	,	PUNCT
aiua-13762	244	45	and	and	CCONJ
aiua-13762	244	46	a	a	DET
aiua-13762	244	47	family	family	NOUN
aiua-13762	244	48	history	history	NOUN
aiua-13762	244	49	of	of	ADP
aiua-13762	244	50	cancers	cancer	NOUN
aiua-13762	244	51	associated	associate	VERB
aiua-13762	244	52	with	with	ADP
aiua-13762	244	53	hereditary	hereditary	ADJ
aiua-13762	244	54	syndromes	syndrome	NOUN
aiua-13762	244	55	,	,	PUNCT
aiua-13762	244	56	such	such	ADJ
aiua-13762	244	57	as	as	ADP
aiua-13762	244	58	hboc	hboc	NOUN
aiua-13762	244	59	or	or	CCONJ
aiua-13762	244	60	lynch	lynch	PROPN
aiua-13762	244	61	syndrome	syndrome	PROPN
aiua-13762	244	62	(	(	PUNCT
aiua-13762	244	63	93	93	NUM
aiua-13762	244	64	)	)	PUNCT
aiua-13762	244	65	.	.	PUNCT
aiua-13762	245	1	the	the	DET
aiua-13762	245	2	inclusion	inclusion	NOUN
aiua-13762	245	3	of	of	ADP
aiua-13762	245	4	ashkenazi	ashkenazi	ADJ
aiua-13762	245	5	ethnicity	ethnicity	NOUN
aiua-13762	245	6	in	in	ADP
aiua-13762	245	7	these	these	DET
aiua-13762	245	8	criteria	criterion	NOUN
aiua-13762	245	9	reflects	reflect	VERB
aiua-13762	245	10	the	the	DET
aiua-13762	245	11	growing	grow	VERB
aiua-13762	245	12	body	body	NOUN
aiua-13762	245	13	of	of	ADP
aiua-13762	245	14	evidence	evidence	NOUN
aiua-13762	245	15	regarding	regard	VERB
aiua-13762	245	16	certain	certain	ADJ
aiua-13762	245	17	predisposing	predispose	VERB
aiua-13762	245	18	mutations	mutation	NOUN
aiua-13762	245	19	,	,	PUNCT
aiua-13762	245	20	such	such	ADJ
aiua-13762	245	21	as	as	ADP
aiua-13762	245	22	brca2	brca2	PROPN
aiua-13762	245	23	,	,	PUNCT
aiua-13762	245	24	which	which	PRON
aiua-13762	245	25	informs	inform	VERB
aiua-13762	245	26	decision	decision	NOUN
aiua-13762	245	27	-	-	PUNCT
aiua-13762	245	28	making	making	NOUN
aiua-13762	245	29	in	in	ADP
aiua-13762	245	30	the	the	DET
aiua-13762	245	31	philadelphia	philadelphia	PROPN
aiua-13762	245	32	guidelines	guideline	NOUN
aiua-13762	245	33	.	.	PUNCT
aiua-13762	246	1	additional	additional	ADJ
aiua-13762	246	2	guidelines	guideline	NOUN
aiua-13762	246	3	recommend	recommend	VERB
aiua-13762	246	4	germline	germline	NOUN
aiua-13762	246	5	testing	testing	NOUN
aiua-13762	246	6	for	for	ADP
aiua-13762	246	7	patients	patient	NOUN
aiua-13762	246	8	of	of	ADP
aiua-13762	246	9	aj	aj	PROPN
aiua-13762	246	10	ancestry	ancestry	PROPN
aiua-13762	246	11	.	.	PUNCT
aiua-13762	247	1	these	these	PRON
aiua-13762	247	2	include	include	VERB
aiua-13762	247	3	the	the	DET
aiua-13762	247	4	american	american	PROPN
aiua-13762	247	5	urological	urological	PROPN
aiua-13762	247	6	association	association	PROPN
aiua-13762	247	7	2022	2022	NUM
aiua-13762	247	8	advanced	advanced	ADJ
aiua-13762	247	9	prostate	prostate	NOUN
aiua-13762	247	10	cancer	cancer	NOUN
aiua-13762	247	11	guidelines	guideline	NOUN
aiua-13762	247	12	,	,	PUNCT
aiua-13762	247	13	the	the	DET
aiua-13762	247	14	australian	australian	ADJ
aiua-13762	247	15	eviq	eviq	ADJ
aiua-13762	247	16	prostate	prostate	NOUN
aiua-13762	247	17	cancer	cancer	NOUN
aiua-13762	247	18	panel	panel	NOUN
aiua-13762	247	19	testing	testing	NOUN
aiua-13762	247	20	guides	guide	NOUN
aiua-13762	247	21	,	,	PUNCT
aiua-13762	247	22	and	and	CCONJ
aiua-13762	247	23	the	the	DET
aiua-13762	247	24	us	us	PROPN
aiua-13762	247	25	national	national	PROPN
aiua-13762	247	26	comprehensive	comprehensive	ADJ
aiua-13762	247	27	cancer	cancer	NOUN
aiua-13762	247	28	network	network	NOUN
aiua-13762	247	29	clinical	clinical	ADJ
aiua-13762	247	30	practice	practice	NOUN
aiua-13762	247	31	guidelines	guideline	NOUN
aiua-13762	247	32	in	in	ADP
aiua-13762	247	33	oncology	oncology	NOUN
aiua-13762	247	34	(	(	PUNCT
aiua-13762	247	35	94	94	NUM
aiua-13762	247	36	)	)	PUNCT
aiua-13762	247	37	.	.	PUNCT
aiua-13762	248	1	importantly	importantly	ADV
aiua-13762	248	2	,	,	PUNCT
aiua-13762	248	3	the	the	DET
aiua-13762	248	4	national	national	PROPN
aiua-13762	248	5	health	health	PROPN
aiua-13762	248	6	service	service	NOUN
aiua-13762	248	7	of	of	ADP
aiua-13762	248	8	the	the	DET
aiua-13762	248	9	united	united	PROPN
aiua-13762	248	10	kingdom	kingdom	PROPN
aiua-13762	248	11	has	have	AUX
aiua-13762	248	12	recently	recently	ADV
aiua-13762	248	13	initiated	initiate	VERB
aiua-13762	248	14	a	a	DET
aiua-13762	248	15	special	special	ADJ
aiua-13762	248	16	jewish	jewish	ADJ
aiua-13762	248	17	brca	brca	PROPN
aiua-13762	248	18	testing	testing	NOUN
aiua-13762	248	19	program	program	NOUN
aiua-13762	248	20	aimed	aim	VERB
aiua-13762	248	21	at	at	ADP
aiua-13762	248	22	identifying	identify	VERB
aiua-13762	248	23	jewish	jewish	ADJ
aiua-13762	248	24	carriers	carrier	NOUN
aiua-13762	248	25	of	of	ADP
aiua-13762	248	26	deleterious	deleterious	ADJ
aiua-13762	248	27	mutations	mutation	NOUN
aiua-13762	248	28	at	at	ADP
aiua-13762	248	29	risk	risk	NOUN
aiua-13762	248	30	for	for	ADP
aiua-13762	248	31	breast	breast	NOUN
aiua-13762	248	32	,	,	PUNCT
aiua-13762	248	33	ovarian	ovarian	ADJ
aiua-13762	248	34	and	and	CCONJ
aiua-13762	248	35	prostate	prostate	NOUN
aiua-13762	248	36	cancer	cancer	NOUN
aiua-13762	248	37	.	.	PUNCT
aiua-13762	249	1	testing	testing	NOUN
aiua-13762	249	2	is	be	AUX
aiua-13762	249	3	available	available	ADJ
aiua-13762	249	4	to	to	ADP
aiua-13762	249	5	individuals	individual	NOUN
aiua-13762	249	6	over	over	ADP
aiua-13762	249	7	the	the	DET
aiua-13762	249	8	age	age	NOUN
aiua-13762	249	9	of	of	ADP
aiua-13762	249	10	18	18	NUM
aiua-13762	249	11	with	with	ADP
aiua-13762	249	12	jewish	jewish	ADJ
aiua-13762	249	13	ancestry	ancestry	NOUN
aiua-13762	249	14	documented	document	VERB
aiua-13762	249	15	by	by	ADP
aiua-13762	249	16	at	at	ADV
aiua-13762	249	17	least	least	ADV
aiua-13762	249	18	one	one	NUM
aiua-13762	249	19	jewish	jewish	ADJ
aiua-13762	249	20	grandparent	grandparent	NOUN
aiua-13762	249	21	(	(	PUNCT
aiua-13762	249	22	95	95	NUM
aiua-13762	249	23	)	)	PUNCT
aiua-13762	249	24	.	.	PUNCT
aiua-13762	250	1	in	in	ADP
aiua-13762	250	2	israel	israel	PROPN
aiua-13762	250	3	,	,	PUNCT
aiua-13762	250	4	patients	patient	NOUN
aiua-13762	250	5	with	with	ADP
aiua-13762	250	6	metastatic	metastatic	ADJ
aiua-13762	250	7	prostate	prostate	NOUN
aiua-13762	250	8	cancer	cancer	NOUN
aiua-13762	250	9	have	have	VERB
aiua-13762	250	10	access	access	NOUN
aiua-13762	250	11	to	to	ADP
aiua-13762	250	12	a	a	DET
aiua-13762	250	13	comprehensive	comprehensive	ADJ
aiua-13762	250	14	sequencing	sequence	VERB
aiua-13762	250	15	panel	panel	NOUN
aiua-13762	250	16	through	through	ADP
aiua-13762	250	17	the	the	DET
aiua-13762	250	18	public	public	ADJ
aiua-13762	250	19	health	health	NOUN
aiua-13762	250	20	services	service	NOUN
aiua-13762	250	21	basket	basket	NOUN
aiua-13762	250	22	,	,	PUNCT
aiua-13762	250	23	which	which	PRON
aiua-13762	250	24	provides	provide	VERB
aiua-13762	250	25	essential	essential	ADJ
aiua-13762	250	26	healthcare	healthcare	NOUN
aiua-13762	250	27	services	service	NOUN
aiua-13762	250	28	to	to	ADP
aiua-13762	250	29	all	all	DET
aiua-13762	250	30	citizens	citizen	NOUN
aiua-13762	250	31	.	.	PUNCT
aiua-13762	251	1	major	major	ADJ
aiua-13762	251	2	hospital	hospital	NOUN
aiua-13762	251	3	institutions	institution	NOUN
aiua-13762	251	4	,	,	PUNCT
aiua-13762	251	5	such	such	ADJ
aiua-13762	251	6	as	as	ADP
aiua-13762	251	7	the	the	DET
aiua-13762	251	8	hadassah	hadassah	PROPN
aiua-13762	251	9	archivio	archivio	PROPN
aiua-13762	251	10	italiano	italiano	X
aiua-13762	251	11	di	di	X
aiua-13762	251	12	urologia	urologia	PROPN
aiua-13762	251	13	e	e	PROPN
aiua-13762	251	14	andrologia	andrologia	NOUN
aiua-13762	251	15	2025	2025	NUM
aiua-13762	251	16	;	;	PUNCT
aiua-13762	251	17	97(2):13762	97(2):13762	NUM
aiua-13762	251	18	g.	g.	PROPN
aiua-13762	251	19	perletti	perletti	PROPN
aiua-13762	251	20	,	,	PUNCT
aiua-13762	251	21	d.	d.	PROPN
aiua-13762	251	22	cohen	cohen	PROPN
aiua-13762	251	23	hattab	hattab	PROPN
aiua-13762	251	24	,	,	PUNCT
aiua-13762	251	25	s.	s.	PROPN
aiua-13762	251	26	dellapergola	dellapergola	PROPN
aiua-13762	251	27	,	,	PUNCT
aiua-13762	251	28	et	et	PROPN
aiua-13762	251	29	al	al	PROPN
aiua-13762	251	30	.	.	PROPN
aiua-13762	251	31	8	8	NUM
aiua-13762	251	32	medical	medical	ADJ
aiua-13762	251	33	center	center	NOUN
aiua-13762	251	34	in	in	ADP
aiua-13762	251	35	jerusalem	jerusalem	PROPN
aiua-13762	251	36	,	,	PUNCT
aiua-13762	251	37	offer	offer	VERB
aiua-13762	251	38	tests	test	NOUN
aiua-13762	251	39	comparable	comparable	ADJ
aiua-13762	251	40	to	to	ADP
aiua-13762	251	41	the	the	DET
aiua-13762	251	42	foundationone	foundationone	ADJ
aiua-13762	251	43	®	®	NOUN
aiua-13762	251	44	cdx	cdx	NOUN
aiua-13762	251	45	test	test	NOUN
aiua-13762	251	46	(	(	PUNCT
aiua-13762	251	47	96	96	NUM
aiua-13762	251	48	)	)	PUNCT
aiua-13762	251	49	.	.	PUNCT
aiua-13762	252	1	these	these	PRON
aiua-13762	252	2	include	include	VERB
aiua-13762	252	3	a	a	DET
aiua-13762	252	4	dedicated	dedicated	ADJ
aiua-13762	252	5	prostate	prostate	NOUN
aiua-13762	252	6	cancer	cancer	NOUN
aiua-13762	252	7	panel	panel	NOUN
aiua-13762	252	8	that	that	PRON
aiua-13762	252	9	assesses	assess	VERB
aiua-13762	252	10	genetic	genetic	ADJ
aiua-13762	252	11	alterations	alteration	NOUN
aiua-13762	252	12	in	in	ADP
aiua-13762	252	13	key	key	ADJ
aiua-13762	252	14	genes	gene	NOUN
aiua-13762	252	15	,	,	PUNCT
aiua-13762	252	16	such	such	ADJ
aiua-13762	252	17	as	as	ADP
aiua-13762	252	18	brca1	brca1	PROPN
aiua-13762	252	19	,	,	PUNCT
aiua-13762	252	20	brca2	brca2	PROPN
aiua-13762	252	21	,	,	PUNCT
aiua-13762	252	22	atm	atm	PROPN
aiua-13762	252	23	,	,	PUNCT
aiua-13762	252	24	bard1	bard1	PROPN
aiua-13762	252	25	,	,	PUNCT
aiua-13762	252	26	brip1	brip1	PROPN
aiua-13762	252	27	,	,	PUNCT
aiua-13762	252	28	cdk12	cdk12	PROPN
aiua-13762	252	29	,	,	PUNCT
aiua-13762	252	30	chek1	chek1	PROPN
aiua-13762	252	31	,	,	PUNCT
aiua-13762	252	32	chek2	chek2	NOUN
aiua-13762	252	33	,	,	PUNCT
aiua-13762	252	34	fancl	fancl	NOUN
aiua-13762	252	35	,	,	PUNCT
aiua-13762	252	36	palb2	palb2	NOUN
aiua-13762	252	37	,	,	PUNCT
aiua-13762	252	38	rad51b	rad51b	NUM
aiua-13762	252	39	,	,	PUNCT
aiua-13762	252	40	rad51c	rad51c	NOUN
aiua-13762	252	41	,	,	PUNCT
aiua-13762	252	42	rad51d	rad51d	NOUN
aiua-13762	252	43	,	,	PUNCT
aiua-13762	252	44	and	and	CCONJ
aiua-13762	252	45	rad54l	rad54l	NOUN
aiua-13762	252	46	.	.	X
aiua-13762	253	1	sequencing	sequence	VERB
aiua-13762	253	2	for	for	ADP
aiua-13762	253	3	the	the	DET
aiua-13762	253	4	mlh1	mlh1	PROPN
aiua-13762	253	5	,	,	PUNCT
aiua-13762	253	6	msh2	msh2	NOUN
aiua-13762	253	7	,	,	PUNCT
aiua-13762	253	8	msh3	msh3	PROPN
aiua-13762	253	9	,	,	PUNCT
aiua-13762	253	10	and	and	CCONJ
aiua-13762	253	11	msh6	msh6	VERB
aiua-13762	253	12	mmr	mmr	PROPN
aiua-13762	253	13	genes	gene	NOUN
aiua-13762	253	14	is	be	AUX
aiua-13762	253	15	also	also	ADV
aiua-13762	253	16	available	available	ADJ
aiua-13762	253	17	.	.	PUNCT
aiua-13762	254	1	other	other	ADJ
aiua-13762	254	2	israeli	israeli	ADJ
aiua-13762	254	3	hospitals	hospital	NOUN
aiua-13762	254	4	provide	provide	VERB
aiua-13762	254	5	tests	test	NOUN
aiua-13762	254	6	that	that	PRON
aiua-13762	254	7	analyze	analyze	VERB
aiua-13762	254	8	mutation	mutation	NOUN
aiua-13762	254	9	burdens	burden	NOUN
aiua-13762	254	10	and	and	CCONJ
aiua-13762	254	11	microsatellite	microsatellite	ADJ
aiua-13762	254	12	instability	instability	NOUN
aiua-13762	254	13	across	across	ADP
aiua-13762	254	14	panels	panel	NOUN
aiua-13762	254	15	of	of	ADP
aiua-13762	254	16	approximately	approximately	ADV
aiua-13762	254	17	400	400	NUM
aiua-13762	254	18	-	-	SYM
aiua-13762	254	19	500	500	NUM
aiua-13762	254	20	genes	gene	NOUN
aiua-13762	254	21	,	,	PUNCT
aiua-13762	254	22	including	include	VERB
aiua-13762	254	23	brca1	brca1	PROPN
aiua-13762	254	24	and	and	CCONJ
aiua-13762	254	25	brca2	brca2	PROPN
aiua-13762	254	26	.	.	PUNCT
aiua-13762	255	1	this	this	DET
aiua-13762	255	2	multifaceted	multifaceted	ADJ
aiua-13762	255	3	approach	approach	NOUN
aiua-13762	255	4	to	to	ADP
aiua-13762	255	5	genetic	genetic	ADJ
aiua-13762	255	6	testing	testing	NOUN
aiua-13762	255	7	enhances	enhance	VERB
aiua-13762	255	8	the	the	DET
aiua-13762	255	9	ability	ability	NOUN
aiua-13762	255	10	to	to	PART
aiua-13762	255	11	tailor	tailor	VERB
aiua-13762	255	12	surveillance	surveillance	NOUN
aiua-13762	255	13	and	and	CCONJ
aiua-13762	255	14	treatment	treatment	NOUN
aiua-13762	255	15	strategies	strategy	NOUN
aiua-13762	255	16	for	for	ADP
aiua-13762	255	17	patients	patient	NOUN
aiua-13762	255	18	at	at	ADP
aiua-13762	255	19	increased	increase	VERB
aiua-13762	255	20	risk	risk	NOUN
aiua-13762	255	21	of	of	ADP
aiua-13762	255	22	prostate	prostate	NOUN
aiua-13762	255	23	cancer	cancer	NOUN
aiua-13762	255	24	.	.	PUNCT
aiua-13762	256	1	diagnosis	diagnosis	NOUN
aiua-13762	256	2	a	a	DET
aiua-13762	256	3	study	study	NOUN
aiua-13762	256	4	by	by	ADP
aiua-13762	256	5	tamir	tamir	PROPN
aiua-13762	256	6	et	et	PROPN
aiua-13762	256	7	al	al	PROPN
aiua-13762	256	8	.	.	PROPN
aiua-13762	256	9	examined	examine	VERB
aiua-13762	256	10	age	age	NOUN
aiua-13762	256	11	-	-	PUNCT
aiua-13762	256	12	related	relate	VERB
aiua-13762	256	13	changes	change	NOUN
aiua-13762	256	14	in	in	ADP
aiua-13762	256	15	the	the	DET
aiua-13762	256	16	prostate	prostate	NOUN
aiua-13762	256	17	through	through	ADP
aiua-13762	256	18	magnetic	magnetic	ADJ
aiua-13762	256	19	resonance	resonance	NOUN
aiua-13762	256	20	imaging	imaging	NOUN
aiua-13762	256	21	among	among	ADP
aiua-13762	256	22	brca	brca	PROPN
aiua-13762	256	23	mutation	mutation	NOUN
aiua-13762	256	24	carriers	carrier	NOUN
aiua-13762	256	25	.	.	PUNCT
aiua-13762	257	1	the	the	DET
aiua-13762	257	2	study	study	NOUN
aiua-13762	257	3	revealed	reveal	VERB
aiua-13762	257	4	significant	significant	ADJ
aiua-13762	257	5	quantitative	quantitative	ADJ
aiua-13762	257	6	alterations	alteration	NOUN
aiua-13762	257	7	,	,	PUNCT
aiua-13762	257	8	including	include	VERB
aiua-13762	257	9	changes	change	NOUN
aiua-13762	257	10	in	in	ADP
aiua-13762	257	11	prostate	prostate	NOUN
aiua-13762	257	12	volume	volume	NOUN
aiua-13762	257	13	,	,	PUNCT
aiua-13762	257	14	as	as	ADV
aiua-13762	257	15	well	well	ADV
aiua-13762	257	16	as	as	ADP
aiua-13762	257	17	qualitative	qualitative	ADJ
aiua-13762	257	18	variations	variation	NOUN
aiua-13762	257	19	in	in	ADP
aiua-13762	257	20	tissue	tissue	NOUN
aiua-13762	257	21	characteristics	characteristic	NOUN
aiua-13762	257	22	,	,	PUNCT
aiua-13762	257	23	such	such	ADJ
aiua-13762	257	24	as	as	ADP
aiua-13762	257	25	lesions	lesion	NOUN
aiua-13762	257	26	and	and	CCONJ
aiua-13762	257	27	fluctuations	fluctuation	NOUN
aiua-13762	257	28	in	in	ADP
aiua-13762	257	29	signal	signal	ADJ
aiua-13762	257	30	intensity	intensity	NOUN
aiua-13762	257	31	.	.	PUNCT
aiua-13762	258	1	these	these	DET
aiua-13762	258	2	findings	finding	NOUN
aiua-13762	258	3	have	have	VERB
aiua-13762	258	4	important	important	ADJ
aiua-13762	258	5	implications	implication	NOUN
aiua-13762	258	6	for	for	ADP
aiua-13762	258	7	brca	brca	PROPN
aiua-13762	258	8	mutation	mutation	NOUN
aiua-13762	258	9	carriers	carrier	NOUN
aiua-13762	258	10	,	,	PUNCT
aiua-13762	258	11	highlighting	highlight	VERB
aiua-13762	258	12	the	the	DET
aiua-13762	258	13	potential	potential	ADJ
aiua-13762	258	14	benefits	benefit	NOUN
aiua-13762	258	15	of	of	ADP
aiua-13762	258	16	tailored	tailor	VERB
aiua-13762	258	17	mri	mri	NOUN
aiua-13762	258	18	screening	screening	NOUN
aiua-13762	258	19	for	for	ADP
aiua-13762	258	20	early	early	ADJ
aiua-13762	258	21	prostate	prostate	NOUN
aiua-13762	258	22	cancer	cancer	NOUN
aiua-13762	258	23	detection	detection	NOUN
aiua-13762	258	24	and	and	CCONJ
aiua-13762	258	25	ongoing	ongoing	ADJ
aiua-13762	258	26	monitoring	monitoring	NOUN
aiua-13762	258	27	(	(	PUNCT
aiua-13762	258	28	97	97	NUM
aiua-13762	258	29	)	)	PUNCT
aiua-13762	258	30	.	.	PUNCT
aiua-13762	259	1	counseling	counsel	VERB
aiua-13762	259	2	genetic	genetic	ADJ
aiua-13762	259	3	counseling	counseling	NOUN
aiua-13762	259	4	is	be	AUX
aiua-13762	259	5	a	a	DET
aiua-13762	259	6	cornerstone	cornerstone	NOUN
aiua-13762	259	7	in	in	ADP
aiua-13762	259	8	the	the	DET
aiua-13762	259	9	prevention	prevention	NOUN
aiua-13762	259	10	,	,	PUNCT
aiua-13762	259	11	diagnosis	diagnosis	NOUN
aiua-13762	259	12	,	,	PUNCT
aiua-13762	259	13	and	and	CCONJ
aiua-13762	259	14	treatment	treatment	NOUN
aiua-13762	259	15	of	of	ADP
aiua-13762	259	16	familial	familial	ADJ
aiua-13762	259	17	cancers	cancer	NOUN
aiua-13762	259	18	.	.	PUNCT
aiua-13762	260	1	counseling	counsel	VERB
aiua-13762	260	2	about	about	ADP
aiua-13762	260	3	the	the	DET
aiua-13762	260	4	implications	implication	NOUN
aiua-13762	260	5	of	of	ADP
aiua-13762	260	6	specific	specific	ADJ
aiua-13762	260	7	mutations	mutation	NOUN
aiua-13762	260	8	and	and	CCONJ
aiua-13762	260	9	the	the	DET
aiua-13762	260	10	importance	importance	NOUN
aiua-13762	260	11	of	of	ADP
aiua-13762	260	12	surveillance	surveillance	NOUN
aiua-13762	260	13	should	should	AUX
aiua-13762	260	14	be	be	AUX
aiua-13762	260	15	routinely	routinely	ADV
aiua-13762	260	16	implemented	implement	VERB
aiua-13762	260	17	for	for	ADP
aiua-13762	260	18	men	man	NOUN
aiua-13762	260	19	with	with	ADP
aiua-13762	260	20	a	a	DET
aiua-13762	260	21	family	family	NOUN
aiua-13762	260	22	history	history	NOUN
aiua-13762	260	23	of	of	ADP
aiua-13762	260	24	cancer	cancer	NOUN
aiua-13762	260	25	.	.	PUNCT
aiua-13762	261	1	for	for	ADP
aiua-13762	261	2	informed	informed	ADJ
aiua-13762	261	3	decisionmaking	decisionmaking	NOUN
aiua-13762	261	4	in	in	ADP
aiua-13762	261	5	pca	pca	PROPN
aiua-13762	261	6	,	,	PUNCT
aiua-13762	261	7	specific	specific	ADJ
aiua-13762	261	8	algorithms	algorithm	NOUN
aiua-13762	261	9	are	be	AUX
aiua-13762	261	10	used	use	VERB
aiua-13762	261	11	,	,	PUNCT
aiua-13762	261	12	such	such	ADJ
aiua-13762	261	13	as	as	ADP
aiua-13762	261	14	the	the	DET
aiua-13762	261	15	one	one	NOUN
aiua-13762	261	16	described	describe	VERB
aiua-13762	261	17	by	by	ADP
aiua-13762	261	18	russo	russo	NOUN
aiua-13762	261	19	and	and	CCONJ
aiua-13762	261	20	coworkers	coworker	NOUN
aiua-13762	261	21	(	(	PUNCT
aiua-13762	261	22	figure	figure	NOUN
aiua-13762	261	23	1	1	NUM
aiua-13762	261	24	in	in	ADP
aiua-13762	261	25	:	:	PUNCT
aiua-13762	261	26	98	98	NUM
aiua-13762	261	27	)	)	PUNCT
aiua-13762	261	28	.	.	PUNCT
aiua-13762	262	1	a	a	DET
aiua-13762	262	2	2008	2008	NUM
aiua-13762	262	3	article	article	NOUN
aiua-13762	262	4	by	by	ADP
aiua-13762	262	5	mohamad	mohamad	PROPN
aiua-13762	262	6	and	and	CCONJ
aiua-13762	262	7	apffelstaedt	apffelstaedt	PROPN
aiua-13762	262	8	emphasized	emphasize	VERB
aiua-13762	262	9	the	the	DET
aiua-13762	262	10	importance	importance	NOUN
aiua-13762	262	11	of	of	ADP
aiua-13762	262	12	counseling	counseling	NOUN
aiua-13762	262	13	for	for	ADP
aiua-13762	262	14	male	male	ADJ
aiua-13762	262	15	brca	brca	PROPN
aiua-13762	262	16	mutation	mutation	NOUN
aiua-13762	262	17	carfigure	carfigure	NOUN
aiua-13762	262	18	1	1	NUM
aiua-13762	262	19	.	.	PUNCT
aiua-13762	263	1	summary	summary	NOUN
aiua-13762	263	2	of	of	ADP
aiua-13762	263	3	studies	study	NOUN
aiua-13762	263	4	included	include	VERB
aiua-13762	263	5	in	in	ADP
aiua-13762	263	6	this	this	DET
aiua-13762	263	7	review	review	NOUN
aiua-13762	263	8	,	,	PUNCT
aiua-13762	263	9	comparing	compare	VERB
aiua-13762	263	10	the	the	DET
aiua-13762	263	11	prevalence	prevalence	NOUN
aiua-13762	263	12	of	of	ADP
aiua-13762	263	13	accepted	accepted	ADJ
aiua-13762	263	14	or	or	CCONJ
aiua-13762	263	15	putative	putative	ADJ
aiua-13762	263	16	predisposing	predispose	VERB
aiua-13762	263	17	mutations	mutation	NOUN
aiua-13762	263	18	in	in	ADP
aiua-13762	263	19	cohorts	cohort	NOUN
aiua-13762	263	20	of	of	ADP
aiua-13762	263	21	ashkenazi	ashkenazi	ADJ
aiua-13762	263	22	prostate	prostate	NOUN
aiua-13762	263	23	cancer	cancer	NOUN
aiua-13762	263	24	cases	case	NOUN
aiua-13762	263	25	and	and	CCONJ
aiua-13762	263	26	healthy	healthy	ADJ
aiua-13762	263	27	ashkenazi	ashkenazi	ADJ
aiua-13762	263	28	male	male	ADJ
aiua-13762	263	29	controls	control	NOUN
aiua-13762	263	30	.	.	PUNCT
aiua-13762	264	1	controlled	control	VERB
aiua-13762	264	2	studies	study	NOUN
aiua-13762	264	3	showing	show	VERB
aiua-13762	264	4	sufficient	sufficient	ADJ
aiua-13762	264	5	design	design	NOUN
aiua-13762	264	6	and	and	CCONJ
aiua-13762	264	7	accrual	accrual	ADJ
aiua-13762	264	8	similarities	similarity	NOUN
aiua-13762	264	9	were	be	AUX
aiua-13762	264	10	included	include	VERB
aiua-13762	264	11	and	and	CCONJ
aiua-13762	264	12	pooled	pool	VERB
aiua-13762	264	13	.	.	PUNCT
aiua-13762	265	1	data	datum	NOUN
aiua-13762	265	2	to	to	ADP
aiua-13762	265	3	the	the	DET
aiua-13762	265	4	right	right	NOUN
aiua-13762	265	5	of	of	ADP
aiua-13762	265	6	the	the	DET
aiua-13762	265	7	no	no	DET
aiua-13762	265	8	-	-	PUNCT
aiua-13762	265	9	effect	effect	NOUN
aiua-13762	265	10	line	line	NOUN
aiua-13762	265	11	represent	represent	VERB
aiua-13762	265	12	increased	increase	VERB
aiua-13762	265	13	odds	odd	NOUN
aiua-13762	265	14	of	of	ADP
aiua-13762	265	15	finding	find	VERB
aiua-13762	265	16	a	a	DET
aiua-13762	265	17	specific	specific	ADJ
aiua-13762	265	18	mutation	mutation	NOUN
aiua-13762	265	19	in	in	ADP
aiua-13762	265	20	brca1	brca1	PROPN
aiua-13762	265	21	(	(	PUNCT
aiua-13762	265	22	panels	panel	NOUN
aiua-13762	265	23	a	a	PRON
aiua-13762	265	24	and	and	CCONJ
aiua-13762	265	25	b	b	NOUN
aiua-13762	265	26	)	)	PUNCT
aiua-13762	265	27	,	,	PUNCT
aiua-13762	265	28	brca2	brca2	PROPN
aiua-13762	265	29	(	(	PUNCT
aiua-13762	265	30	panel	panel	NOUN
aiua-13762	265	31	c	c	NOUN
aiua-13762	265	32	)	)	PUNCT
aiua-13762	265	33	or	or	CCONJ
aiua-13762	265	34	rnasel	rnasel	NOUN
aiua-13762	265	35	(	(	PUNCT
aiua-13762	265	36	panel	panel	NOUN
aiua-13762	265	37	d	d	NOUN
aiua-13762	265	38	)	)	PUNCT
aiua-13762	265	39	in	in	ADP
aiua-13762	265	40	prostate	prostate	NOUN
aiua-13762	265	41	cancer	cancer	NOUN
aiua-13762	265	42	patients	patient	NOUN
aiua-13762	265	43	compared	compare	VERB
aiua-13762	265	44	to	to	ADP
aiua-13762	265	45	controls	control	NOUN
aiua-13762	265	46	.	.	PUNCT
aiua-13762	266	1	overall	overall	ADJ
aiua-13762	266	2	effect	effect	NOUN
aiua-13762	266	3	sizes	size	NOUN
aiua-13762	266	4	(	(	PUNCT
aiua-13762	266	5	odds	odd	NOUN
aiua-13762	266	6	ratios	ratio	NOUN
aiua-13762	266	7	)	)	PUNCT
aiua-13762	266	8	extending	extend	VERB
aiua-13762	266	9	to	to	ADP
aiua-13762	266	10	the	the	DET
aiua-13762	266	11	upper	upper	ADJ
aiua-13762	266	12	and	and	CCONJ
aiua-13762	266	13	lower	low	ADJ
aiua-13762	266	14	limits	limit	NOUN
aiua-13762	266	15	of	of	ADP
aiua-13762	266	16	the	the	DET
aiua-13762	266	17	95	95	NUM
aiua-13762	266	18	%	%	NOUN
aiua-13762	266	19	confidence	confidence	NOUN
aiua-13762	266	20	intervals	interval	NOUN
aiua-13762	266	21	,	,	PUNCT
aiua-13762	266	22	the	the	DET
aiua-13762	266	23	significance	significance	NOUN
aiua-13762	266	24	of	of	ADP
aiua-13762	266	25	the	the	DET
aiua-13762	266	26	pooled	pooled	ADJ
aiua-13762	266	27	effect	effect	NOUN
aiua-13762	266	28	sizes	size	NOUN
aiua-13762	266	29	(	(	PUNCT
aiua-13762	266	30	z	z	NOUN
aiua-13762	266	31	statistics	statistic	NOUN
aiua-13762	266	32	)	)	PUNCT
aiua-13762	266	33	and	and	CCONJ
aiua-13762	266	34	heterogeneity	heterogeneity	NOUN
aiua-13762	266	35	data	datum	NOUN
aiua-13762	266	36	(	(	PUNCT
aiua-13762	266	37	i^2	i^2	PROPN
aiua-13762	266	38	)	)	PUNCT
aiua-13762	266	39	are	be	AUX
aiua-13762	266	40	shown	show	VERB
aiua-13762	266	41	.	.	PUNCT
aiua-13762	267	1	mantel	mantel	NOUN
aiua-13762	267	2	-	-	PUNCT
aiua-13762	267	3	haenszel	haenszel	NOUN
aiua-13762	267	4	weighting	weighting	NOUN
aiua-13762	267	5	method	method	NOUN
aiua-13762	267	6	,	,	PUNCT
aiua-13762	267	7	random	random	ADJ
aiua-13762	267	8	effects	effect	NOUN
aiua-13762	267	9	model	model	NOUN
aiua-13762	267	10	.	.	PUNCT
aiua-13762	268	1	software	software	NOUN
aiua-13762	268	2	:	:	PUNCT
aiua-13762	268	3	meta	meta	ADJ
aiua-13762	268	4	-	-	PUNCT
aiua-13762	268	5	essentials	essential	NOUN
aiua-13762	268	6	excel	excel	VERB
aiua-13762	268	7	workbook	workbook	NOUN
aiua-13762	268	8	1.5	1.5	NUM
aiua-13762	268	9	(	(	PUNCT
aiua-13762	268	10	erim	erim	PROPN
aiua-13762	268	11	,	,	PUNCT
aiua-13762	268	12	erasmus	erasmus	PROPN
aiua-13762	268	13	university	university	PROPN
aiua-13762	268	14	,	,	PUNCT
aiua-13762	268	15	rotterdam	rotterdam	PROPN
aiua-13762	268	16	,	,	PUNCT
aiua-13762	268	17	the	the	DET
aiua-13762	268	18	netherlands	netherlands	PROPN
aiua-13762	268	19	)	)	PUNCT
aiua-13762	268	20	.	.	PUNCT
aiua-13762	269	1	archivio	archivio	NOUN
aiua-13762	269	2	italiano	italiano	PROPN
aiua-13762	269	3	di	di	PROPN
aiua-13762	269	4	urologia	urologia	PROPN
aiua-13762	269	5	e	e	PROPN
aiua-13762	269	6	andrologia	andrologia	NOUN
aiua-13762	269	7	2025	2025	NUM
aiua-13762	269	8	;	;	PUNCT
aiua-13762	269	9	97(2):13762	97(2):13762	NUM
aiua-13762	269	10	9	9	NUM
aiua-13762	269	11	genetic	genetic	NOUN
aiua-13762	269	12	of	of	ADP
aiua-13762	269	13	prostate	prostate	NOUN
aiua-13762	269	14	cancer	cancer	NOUN
aiua-13762	269	15	riers	rier	NOUN
aiua-13762	269	16	,	,	PUNCT
aiua-13762	269	17	particularly	particularly	ADV
aiua-13762	269	18	regarding	regard	VERB
aiua-13762	269	19	their	their	PRON
aiua-13762	269	20	elevated	elevated	ADJ
aiua-13762	269	21	risk	risk	NOUN
aiua-13762	269	22	for	for	ADP
aiua-13762	269	23	prostate	prostate	NOUN
aiua-13762	269	24	,	,	PUNCT
aiua-13762	269	25	pancreatic	pancreatic	ADJ
aiua-13762	269	26	and	and	CCONJ
aiua-13762	269	27	breast	breast	NOUN
aiua-13762	269	28	cancers	cancer	NOUN
aiua-13762	269	29	(	(	PUNCT
aiua-13762	269	30	99	99	NUM
aiua-13762	269	31	)	)	PUNCT
aiua-13762	269	32	.	.	PUNCT
aiua-13762	270	1	it	it	PRON
aiua-13762	270	2	recommends	recommend	VERB
aiua-13762	270	3	tailored	tailor	VERB
aiua-13762	270	4	counseling	counseling	NOUN
aiua-13762	270	5	for	for	ADP
aiua-13762	270	6	male	male	ADJ
aiua-13762	270	7	brca	brca	PROPN
aiua-13762	270	8	carriers	carrier	NOUN
aiua-13762	270	9	,	,	PUNCT
aiua-13762	270	10	as	as	SCONJ
aiua-13762	270	11	they	they	PRON
aiua-13762	270	12	are	be	AUX
aiua-13762	270	13	often	often	ADV
aiua-13762	270	14	unaware	unaware	ADJ
aiua-13762	270	15	of	of	ADP
aiua-13762	270	16	their	their	PRON
aiua-13762	270	17	increased	increase	VERB
aiua-13762	270	18	risks	risk	NOUN
aiua-13762	270	19	and	and	CCONJ
aiua-13762	270	20	may	may	AUX
aiua-13762	270	21	not	not	PART
aiua-13762	270	22	seek	seek	VERB
aiua-13762	270	23	genetic	genetic	ADJ
aiua-13762	270	24	testing	testing	NOUN
aiua-13762	270	25	or	or	CCONJ
aiua-13762	270	26	appropriate	appropriate	ADJ
aiua-13762	270	27	surveillance	surveillance	NOUN
aiua-13762	270	28	.	.	PUNCT
aiua-13762	271	1	in	in	ADP
aiua-13762	271	2	the	the	DET
aiua-13762	271	3	context	context	NOUN
aiua-13762	271	4	of	of	ADP
aiua-13762	271	5	comprehensive	comprehensive	ADJ
aiua-13762	271	6	counseling	counseling	NOUN
aiua-13762	271	7	,	,	PUNCT
aiua-13762	271	8	discussions	discussion	NOUN
aiua-13762	271	9	about	about	ADP
aiua-13762	271	10	lifestyle	lifestyle	NOUN
aiua-13762	271	11	modifications	modification	NOUN
aiua-13762	271	12	may	may	AUX
aiua-13762	271	13	empower	empower	VERB
aiua-13762	271	14	patients	patient	NOUN
aiua-13762	271	15	to	to	PART
aiua-13762	271	16	take	take	VERB
aiua-13762	271	17	an	an	DET
aiua-13762	271	18	active	active	ADJ
aiua-13762	271	19	role	role	NOUN
aiua-13762	271	20	in	in	ADP
aiua-13762	271	21	managing	manage	VERB
aiua-13762	271	22	their	their	PRON
aiua-13762	271	23	health	health	NOUN
aiua-13762	271	24	.	.	PUNCT
aiua-13762	272	1	for	for	ADP
aiua-13762	272	2	example	example	NOUN
aiua-13762	272	3	,	,	PUNCT
aiua-13762	272	4	charred	charred	ADJ
aiua-13762	272	5	meat	meat	NOUN
aiua-13762	272	6	byproducts	byproduct	NOUN
aiua-13762	272	7	,	,	PUNCT
aiua-13762	272	8	particularly	particularly	ADV
aiua-13762	272	9	polycyclic	polycyclic	ADJ
aiua-13762	272	10	aromatic	aromatic	ADJ
aiua-13762	272	11	hydrocarbons	hydrocarbon	NOUN
aiua-13762	272	12	and	and	CCONJ
aiua-13762	272	13	heterocyclic	heterocyclic	ADJ
aiua-13762	272	14	amines	amine	NOUN
aiua-13762	272	15	such	such	ADJ
aiua-13762	272	16	as	as	ADP
aiua-13762	272	17	2	2	NUM
aiua-13762	272	18	-	-	PUNCT
aiua-13762	272	19	amino-1	amino-1	NUM
aiua-13762	272	20	-	-	PUNCT
aiua-13762	272	21	methyl6	methyl6	NOUN
aiua-13762	272	22	-	-	PUNCT
aiua-13762	272	23	phenylimidazo	phenylimidazo	NOUN
aiua-13762	272	24	(	(	PUNCT
aiua-13762	272	25	4,5	4,5	NUM
aiua-13762	272	26	-	-	PUNCT
aiua-13762	272	27	b	b	NOUN
aiua-13762	272	28	)	)	PUNCT
aiua-13762	272	29	pyridine	pyridine	NOUN
aiua-13762	272	30	(	(	PUNCT
aiua-13762	272	31	phip	phip	NOUN
aiua-13762	272	32	)	)	PUNCT
aiua-13762	272	33	,	,	PUNCT
aiua-13762	272	34	have	have	AUX
aiua-13762	272	35	been	be	AUX
aiua-13762	272	36	implicated	implicate	VERB
aiua-13762	272	37	in	in	ADP
aiua-13762	272	38	prostate	prostate	NOUN
aiua-13762	272	39	cancer	cancer	NOUN
aiua-13762	272	40	risk	risk	NOUN
aiua-13762	272	41	.	.	PUNCT
aiua-13762	273	1	(	(	PUNCT
aiua-13762	273	2	100	100	NUM
aiua-13762	273	3	,	,	PUNCT
aiua-13762	273	4	101	101	NUM
aiua-13762	273	5	)	)	PUNCT
aiua-13762	273	6	.	.	PUNCT
aiua-13762	274	1	this	this	DET
aiua-13762	274	2	observation	observation	NOUN
aiua-13762	274	3	is	be	AUX
aiua-13762	274	4	significant	significant	ADJ
aiua-13762	274	5	,	,	PUNCT
aiua-13762	274	6	as	as	SCONJ
aiua-13762	274	7	high	high	ADJ
aiua-13762	274	8	-	-	PUNCT
aiua-13762	274	9	risk	risk	NOUN
aiua-13762	274	10	dietary	dietary	ADJ
aiua-13762	274	11	and	and	CCONJ
aiua-13762	274	12	lifestyle	lifestyle	NOUN
aiua-13762	274	13	behaviors	behavior	NOUN
aiua-13762	274	14	may	may	AUX
aiua-13762	274	15	compound	compound	VERB
aiua-13762	274	16	the	the	DET
aiua-13762	274	17	genetic	genetic	ADJ
aiua-13762	274	18	predisposition	predisposition	NOUN
aiua-13762	274	19	,	,	PUNCT
aiua-13762	274	20	contributing	contribute	VERB
aiua-13762	274	21	to	to	ADP
aiua-13762	274	22	the	the	DET
aiua-13762	274	23	development	development	NOUN
aiua-13762	274	24	of	of	ADP
aiua-13762	274	25	neoplasia	neoplasia	NOUN
aiua-13762	274	26	in	in	ADP
aiua-13762	274	27	at	at	ADP
aiua-13762	274	28	-	-	PUNCT
aiua-13762	274	29	risk	risk	NOUN
aiua-13762	274	30	populations	population	NOUN
aiua-13762	274	31	.	.	PUNCT
aiua-13762	275	1	therapy	therapy	NOUN
aiua-13762	275	2	and	and	CCONJ
aiua-13762	275	3	chemoprevention	chemoprevention	NOUN
aiua-13762	275	4	clinical	clinical	ADJ
aiua-13762	275	5	trials	trial	NOUN
aiua-13762	275	6	have	have	AUX
aiua-13762	275	7	investigated	investigate	VERB
aiua-13762	275	8	the	the	DET
aiua-13762	275	9	impact	impact	NOUN
aiua-13762	275	10	of	of	ADP
aiua-13762	275	11	various	various	ADJ
aiua-13762	275	12	prostate	prostate	NOUN
aiua-13762	275	13	cancer	cancer	NOUN
aiua-13762	275	14	therapies	therapy	NOUN
aiua-13762	275	15	in	in	ADP
aiua-13762	275	16	brca	brca	PROPN
aiua-13762	275	17	mutation	mutation	NOUN
aiua-13762	275	18	carriers	carrier	NOUN
aiua-13762	275	19	.	.	PUNCT
aiua-13762	276	1	gallagher	gallagher	PROPN
aiua-13762	276	2	and	and	CCONJ
aiua-13762	276	3	colleagues	colleague	NOUN
aiua-13762	276	4	studied	study	VERB
aiua-13762	276	5	whether	whether	SCONJ
aiua-13762	276	6	brca1	brca1	PROPN
aiua-13762	276	7	or	or	CCONJ
aiua-13762	276	8	brca2	brca2	NOUN
aiua-13762	276	9	mutations	mutation	NOUN
aiua-13762	276	10	could	could	AUX
aiua-13762	276	11	affect	affect	VERB
aiua-13762	276	12	the	the	DET
aiua-13762	276	13	sensitivity	sensitivity	NOUN
aiua-13762	276	14	to	to	ADP
aiua-13762	276	15	taxane	taxane	NOUN
aiua-13762	276	16	-	-	PUNCT
aiua-13762	276	17	based	base	VERB
aiua-13762	276	18	chemotherapy	chemotherapy	NOUN
aiua-13762	276	19	.	.	PUNCT
aiua-13762	277	1	their	their	PRON
aiua-13762	277	2	study	study	NOUN
aiua-13762	277	3	found	find	VERB
aiua-13762	277	4	that	that	SCONJ
aiua-13762	277	5	57	57	NUM
aiua-13762	277	6	%	%	NOUN
aiua-13762	277	7	of	of	ADP
aiua-13762	277	8	brca	brca	PROPN
aiua-13762	277	9	mutation	mutation	NOUN
aiua-13762	277	10	carriers	carrier	NOUN
aiua-13762	277	11	responded	respond	VERB
aiua-13762	277	12	to	to	ADP
aiua-13762	277	13	chemotherapy	chemotherapy	NOUN
aiua-13762	277	14	,	,	PUNCT
aiua-13762	277	15	compared	compare	VERB
aiua-13762	277	16	to	to	ADP
aiua-13762	277	17	72	72	NUM
aiua-13762	277	18	%	%	NOUN
aiua-13762	277	19	of	of	ADP
aiua-13762	277	20	non	non	NOUN
aiua-13762	277	21	-	-	NOUN
aiua-13762	277	22	carriers	carrier	NOUN
aiua-13762	277	23	(	(	PUNCT
aiua-13762	277	24	n	n	NOUN
aiua-13762	277	25	=	=	NUM
aiua-13762	277	26	81	81	NUM
aiua-13762	277	27	)	)	PUNCT
aiua-13762	277	28	.	.	PUNCT
aiua-13762	278	1	the	the	DET
aiua-13762	278	2	difference	difference	NOUN
aiua-13762	278	3	between	between	ADP
aiua-13762	278	4	the	the	DET
aiua-13762	278	5	groups	group	NOUN
aiua-13762	278	6	was	be	AUX
aiua-13762	278	7	not	not	PART
aiua-13762	278	8	statistically	statistically	ADV
aiua-13762	278	9	significant	significant	ADJ
aiua-13762	278	10	,	,	PUNCT
aiua-13762	278	11	suggesting	suggest	VERB
aiua-13762	278	12	that	that	SCONJ
aiua-13762	278	13	brca	brca	PROPN
aiua-13762	278	14	mutation	mutation	NOUN
aiua-13762	278	15	carriers	carrier	NOUN
aiua-13762	278	16	are	be	AUX
aiua-13762	278	17	indeed	indeed	ADV
aiua-13762	278	18	responsive	responsive	ADJ
aiua-13762	278	19	to	to	ADP
aiua-13762	278	20	chemotherapy	chemotherapy	NOUN
aiua-13762	278	21	(	(	PUNCT
aiua-13762	278	22	102	102	NUM
aiua-13762	278	23	)	)	PUNCT
aiua-13762	278	24	.	.	PUNCT
aiua-13762	279	1	poly	poly	ADJ
aiua-13762	279	2	(	(	PUNCT
aiua-13762	279	3	adp	adp	PROPN
aiua-13762	279	4	-	-	PUNCT
aiua-13762	279	5	ribose	ribose	NOUN
aiua-13762	279	6	)	)	PUNCT
aiua-13762	279	7	polymerase	polymerase	NOUN
aiua-13762	279	8	(	(	PUNCT
aiua-13762	279	9	parp	parp	NOUN
aiua-13762	279	10	)	)	PUNCT
aiua-13762	279	11	,	,	PUNCT
aiua-13762	279	12	which	which	PRON
aiua-13762	279	13	plays	play	VERB
aiua-13762	279	14	a	a	DET
aiua-13762	279	15	crucial	crucial	ADJ
aiua-13762	279	16	role	role	NOUN
aiua-13762	279	17	in	in	ADP
aiua-13762	279	18	dna	dna	PROPN
aiua-13762	279	19	repair	repair	NOUN
aiua-13762	279	20	and	and	CCONJ
aiua-13762	279	21	apoptosis	apoptosis	NOUN
aiua-13762	279	22	,	,	PUNCT
aiua-13762	279	23	is	be	AUX
aiua-13762	279	24	targeted	target	VERB
aiua-13762	279	25	by	by	ADP
aiua-13762	279	26	inhibitors	inhibitor	NOUN
aiua-13762	279	27	such	such	ADJ
aiua-13762	279	28	as	as	ADP
aiua-13762	279	29	olaparib	olaparib	NOUN
aiua-13762	279	30	,	,	PUNCT
aiua-13762	279	31	rucaparib	rucaparib	PROPN
aiua-13762	279	32	,	,	PUNCT
aiua-13762	279	33	niraparib	niraparib	PROPN
aiua-13762	279	34	and	and	CCONJ
aiua-13762	279	35	talazoparib	talazoparib	PROPN
aiua-13762	279	36	.	.	PUNCT
aiua-13762	280	1	these	these	DET
aiua-13762	280	2	drugs	drug	NOUN
aiua-13762	280	3	are	be	AUX
aiua-13762	280	4	used	use	VERB
aiua-13762	280	5	in	in	ADP
aiua-13762	280	6	the	the	DET
aiua-13762	280	7	treatment	treatment	NOUN
aiua-13762	280	8	of	of	ADP
aiua-13762	280	9	her2	her2	NOUN
aiua-13762	280	10	-	-	PUNCT
aiua-13762	280	11	negative	negative	ADJ
aiua-13762	280	12	,	,	PUNCT
aiua-13762	280	13	familial	familial	ADJ
aiua-13762	280	14	metastatic	metastatic	ADJ
aiua-13762	280	15	breast	breast	NOUN
aiua-13762	280	16	cancer	cancer	NOUN
aiua-13762	280	17	in	in	ADP
aiua-13762	280	18	women	woman	NOUN
aiua-13762	280	19	with	with	ADP
aiua-13762	280	20	brca1	brca1	PROPN
aiua-13762	280	21	or	or	CCONJ
aiua-13762	280	22	brca2	brca2	NOUN
aiua-13762	280	23	mutations	mutation	NOUN
aiua-13762	280	24	.	.	PUNCT
aiua-13762	281	1	given	give	VERB
aiua-13762	281	2	that	that	SCONJ
aiua-13762	281	3	these	these	DET
aiua-13762	281	4	inhibitors	inhibitor	NOUN
aiua-13762	281	5	also	also	ADV
aiua-13762	281	6	suppress	suppress	VERB
aiua-13762	281	7	the	the	DET
aiua-13762	281	8	function	function	NOUN
aiua-13762	281	9	of	of	ADP
aiua-13762	281	10	the	the	DET
aiua-13762	281	11	androgen	androgen	NOUN
aiua-13762	281	12	receptor	receptor	NOUN
aiua-13762	281	13	,	,	PUNCT
aiua-13762	281	14	their	their	PRON
aiua-13762	281	15	use	use	NOUN
aiua-13762	281	16	has	have	AUX
aiua-13762	281	17	been	be	AUX
aiua-13762	281	18	explored	explore	VERB
aiua-13762	281	19	in	in	ADP
aiua-13762	281	20	clinical	clinical	ADJ
aiua-13762	281	21	trials	trial	NOUN
aiua-13762	281	22	for	for	ADP
aiua-13762	281	23	crpc	crpc	ADJ
aiua-13762	281	24	patients	patient	NOUN
aiua-13762	281	25	carrying	carry	VERB
aiua-13762	281	26	mutations	mutation	NOUN
aiua-13762	281	27	in	in	ADP
aiua-13762	281	28	brca1	brca1	PROPN
aiua-13762	281	29	,	,	PUNCT
aiua-13762	281	30	brca2	brca2	PROPN
aiua-13762	281	31	,	,	PUNCT
aiua-13762	281	32	and	and	CCONJ
aiua-13762	281	33	atm	atm	PROPN
aiua-13762	281	34	.	.	PUNCT
aiua-13762	282	1	the	the	DET
aiua-13762	282	2	profound	profound	ADJ
aiua-13762	282	3	phase	phase	NOUN
aiua-13762	282	4	iii	iii	NOUN
aiua-13762	282	5	trial	trial	NOUN
aiua-13762	282	6	demonstrated	demonstrate	VERB
aiua-13762	282	7	that	that	SCONJ
aiua-13762	282	8	progression	progression	NOUN
aiua-13762	282	9	-	-	PUNCT
aiua-13762	282	10	free	free	ADJ
aiua-13762	282	11	survival	survival	NOUN
aiua-13762	282	12	was	be	AUX
aiua-13762	282	13	significantly	significantly	ADV
aiua-13762	282	14	prolonged	prolong	VERB
aiua-13762	282	15	in	in	ADP
aiua-13762	282	16	patients	patient	NOUN
aiua-13762	282	17	treated	treat	VERB
aiua-13762	282	18	with	with	ADP
aiua-13762	282	19	olaparib	olaparib	NOUN
aiua-13762	282	20	compared	compare	VERB
aiua-13762	282	21	to	to	ADP
aiua-13762	282	22	untreated	untreated	ADJ
aiua-13762	282	23	controls	control	NOUN
aiua-13762	282	24	(	(	PUNCT
aiua-13762	282	25	103	103	NUM
aiua-13762	282	26	)	)	PUNCT
aiua-13762	282	27	.	.	PUNCT
aiua-13762	283	1	similarly	similarly	ADV
aiua-13762	283	2	,	,	PUNCT
aiua-13762	283	3	the	the	DET
aiua-13762	283	4	triton2	triton2	NOUN
aiua-13762	283	5	and	and	CCONJ
aiua-13762	283	6	galahad	galahad	NOUN
aiua-13762	283	7	phase	phase	NOUN
aiua-13762	283	8	ii	ii	PROPN
aiua-13762	283	9	trials	trial	NOUN
aiua-13762	283	10	,	,	PUNCT
aiua-13762	283	11	which	which	PRON
aiua-13762	283	12	included	include	VERB
aiua-13762	283	13	patients	patient	NOUN
aiua-13762	283	14	with	with	ADP
aiua-13762	283	15	crpc	crpc	ADJ
aiua-13762	283	16	carrying	carry	VERB
aiua-13762	283	17	brca1/2	brca1/2	ADJ
aiua-13762	283	18	mutations	mutation	NOUN
aiua-13762	283	19	as	as	ADV
aiua-13762	283	20	well	well	ADV
aiua-13762	283	21	as	as	ADP
aiua-13762	283	22	mutations	mutation	NOUN
aiua-13762	283	23	in	in	ADP
aiua-13762	283	24	other	other	ADJ
aiua-13762	283	25	pca	pca	NOUN
aiua-13762	283	26	predisposing	predispose	VERB
aiua-13762	283	27	genes	gene	NOUN
aiua-13762	283	28	,	,	PUNCT
aiua-13762	283	29	showed	show	VERB
aiua-13762	283	30	that	that	SCONJ
aiua-13762	283	31	rucaparib	rucaparib	PROPN
aiua-13762	283	32	and	and	CCONJ
aiua-13762	283	33	niraparib	niraparib	PROPN
aiua-13762	283	34	significantly	significantly	ADV
aiua-13762	283	35	increased	increase	VERB
aiua-13762	283	36	both	both	DET
aiua-13762	283	37	objective	objective	ADJ
aiua-13762	283	38	(	(	PUNCT
aiua-13762	283	39	triton2	triton2	NOUN
aiua-13762	283	40	,	,	PUNCT
aiua-13762	283	41	46	46	NUM
aiua-13762	283	42	%	%	NOUN
aiua-13762	283	43	for	for	ADP
aiua-13762	283	44	brca	brca	PROPN
aiua-13762	283	45	mutation	mutation	NOUN
aiua-13762	283	46	carriers	carrier	NOUN
aiua-13762	283	47	vs.	vs.	ADP
aiua-13762	283	48	0	0	NUM
aiua-13762	283	49	%	%	NOUN
aiua-13762	283	50	for	for	ADP
aiua-13762	283	51	carriers	carrier	NOUN
aiua-13762	283	52	of	of	ADP
aiua-13762	283	53	other	other	ADJ
aiua-13762	283	54	mutations	mutation	NOUN
aiua-13762	283	55	)	)	PUNCT
aiua-13762	283	56	and	and	CCONJ
aiua-13762	283	57	composite	composite	ADJ
aiua-13762	283	58	response	response	NOUN
aiua-13762	283	59	rates	rate	NOUN
aiua-13762	283	60	in	in	ADP
aiua-13762	283	61	treated	treat	VERB
aiua-13762	283	62	subjects	subject	NOUN
aiua-13762	283	63	(	(	PUNCT
aiua-13762	283	64	galahad	galahad	NOUN
aiua-13762	283	65	,	,	PUNCT
aiua-13762	283	66	57.7	57.7	NUM
aiua-13762	283	67	%	%	NOUN
aiua-13762	283	68	in	in	ADP
aiua-13762	283	69	brca	brca	PROPN
aiua-13762	283	70	mutation	mutation	NOUN
aiua-13762	283	71	carriers	carrier	NOUN
aiua-13762	283	72	vs.	vs.	ADP
aiua-13762	283	73	14.8	14.8	NUM
aiua-13762	283	74	%	%	NOUN
aiua-13762	283	75	in	in	ADP
aiua-13762	283	76	non	non	ADJ
aiua-13762	283	77	-	-	NOUN
aiua-13762	283	78	carriers	carrier	NOUN
aiua-13762	283	79	)	)	PUNCT
aiua-13762	283	80	,	,	PUNCT
aiua-13762	283	81	compared	compare	VERB
aiua-13762	283	82	to	to	ADP
aiua-13762	283	83	untreated	untreated	ADJ
aiua-13762	283	84	patients	patient	NOUN
aiua-13762	283	85	(	(	PUNCT
aiua-13762	283	86	104	104	NUM
aiua-13762	283	87	,	,	PUNCT
aiua-13762	283	88	105	105	NUM
aiua-13762	283	89	)	)	PUNCT
aiua-13762	283	90	.	.	PUNCT
aiua-13762	284	1	thus	thus	ADV
aiua-13762	284	2	,	,	PUNCT
aiua-13762	284	3	parp	parp	ADJ
aiua-13762	284	4	inhibitors	inhibitor	NOUN
aiua-13762	284	5	show	show	VERB
aiua-13762	284	6	promising	promise	VERB
aiua-13762	284	7	clinical	clinical	ADJ
aiua-13762	284	8	efficacy	efficacy	NOUN
aiua-13762	284	9	in	in	ADP
aiua-13762	284	10	treating	treat	VERB
aiua-13762	284	11	metastatic	metastatic	ADJ
aiua-13762	284	12	crpc	crpc	ADV
aiua-13762	284	13	in	in	ADP
aiua-13762	284	14	patients	patient	NOUN
aiua-13762	284	15	with	with	ADP
aiua-13762	284	16	mutations	mutation	NOUN
aiua-13762	284	17	in	in	ADP
aiua-13762	284	18	brca1/2	brca1/2	PROPN
aiua-13762	284	19	.	.	PUNCT
aiua-13762	285	1	further	further	ADJ
aiua-13762	285	2	investigation	investigation	NOUN
aiua-13762	285	3	is	be	AUX
aiua-13762	285	4	needed	need	VERB
aiua-13762	285	5	to	to	PART
aiua-13762	285	6	determine	determine	VERB
aiua-13762	285	7	whether	whether	SCONJ
aiua-13762	285	8	patient	patient	ADJ
aiua-13762	285	9	responses	response	NOUN
aiua-13762	285	10	are	be	AUX
aiua-13762	285	11	associated	associate	VERB
aiua-13762	285	12	with	with	ADP
aiua-13762	285	13	specific	specific	ADJ
aiua-13762	285	14	classes	class	NOUN
aiua-13762	285	15	of	of	ADP
aiua-13762	285	16	mutations	mutation	NOUN
aiua-13762	285	17	or	or	CCONJ
aiua-13762	285	18	if	if	SCONJ
aiua-13762	285	19	they	they	PRON
aiua-13762	285	20	can	can	AUX
aiua-13762	285	21	be	be	AUX
aiua-13762	285	22	generalized	generalize	VERB
aiua-13762	285	23	to	to	ADP
aiua-13762	285	24	all	all	DET
aiua-13762	285	25	types	type	NOUN
aiua-13762	285	26	of	of	ADP
aiua-13762	285	27	pathogenic	pathogenic	ADJ
aiua-13762	285	28	brca	brca	PROPN
aiua-13762	285	29	variants	variant	NOUN
aiua-13762	285	30	,	,	PUNCT
aiua-13762	285	31	including	include	VERB
aiua-13762	285	32	ashkenazi	ashkenazi	ADJ
aiua-13762	285	33	founder	founder	NOUN
aiua-13762	285	34	mutations	mutation	NOUN
aiua-13762	285	35	.	.	PUNCT
aiua-13762	286	1	additionally	additionally	ADV
aiua-13762	286	2	,	,	PUNCT
aiua-13762	286	3	the	the	DET
aiua-13762	286	4	impact	impact	NOUN
aiua-13762	286	5	of	of	ADP
aiua-13762	286	6	tumor	tumor	NOUN
aiua-13762	286	7	resistance	resistance	NOUN
aiua-13762	286	8	to	to	ADP
aiua-13762	286	9	parp	parp	ADJ
aiua-13762	286	10	inhibitors	inhibitor	NOUN
aiua-13762	286	11	should	should	AUX
aiua-13762	286	12	be	be	AUX
aiua-13762	286	13	evaluated	evaluate	VERB
aiua-13762	286	14	as	as	SCONJ
aiua-13762	286	15	the	the	DET
aiua-13762	286	16	use	use	NOUN
aiua-13762	286	17	of	of	ADP
aiua-13762	286	18	these	these	DET
aiua-13762	286	19	agents	agent	NOUN
aiua-13762	286	20	becomes	become	VERB
aiua-13762	286	21	more	more	ADV
aiua-13762	286	22	widespread	widespread	ADJ
aiua-13762	286	23	in	in	ADP
aiua-13762	286	24	prostate	prostate	NOUN
aiua-13762	286	25	cancer	cancer	NOUN
aiua-13762	286	26	treatment	treatment	NOUN
aiua-13762	286	27	.	.	PUNCT
aiua-13762	287	1	conclusions	conclusion	NOUN
aiua-13762	287	2	the	the	DET
aiua-13762	287	3	genetic	genetic	ADJ
aiua-13762	287	4	identity	identity	NOUN
aiua-13762	287	5	of	of	ADP
aiua-13762	287	6	aj	aj	PROPN
aiua-13762	287	7	has	have	AUX
aiua-13762	287	8	been	be	AUX
aiua-13762	287	9	shaped	shape	VERB
aiua-13762	287	10	over	over	ADP
aiua-13762	287	11	centuries	century	NOUN
aiua-13762	287	12	by	by	ADP
aiua-13762	287	13	strict	strict	ADJ
aiua-13762	287	14	endogamy	endogamy	NOUN
aiua-13762	287	15	and	and	CCONJ
aiua-13762	287	16	high	high	ADJ
aiua-13762	287	17	reproductive	reproductive	ADJ
aiua-13762	287	18	rates	rate	NOUN
aiua-13762	287	19	,	,	PUNCT
aiua-13762	287	20	factors	factor	NOUN
aiua-13762	287	21	which	which	PRON
aiua-13762	287	22	have	have	AUX
aiua-13762	287	23	been	be	AUX
aiua-13762	287	24	further	far	ADV
aiua-13762	287	25	potentiated	potentiate	VERB
aiua-13762	287	26	by	by	ADP
aiua-13762	287	27	genetic	genetic	ADJ
aiua-13762	287	28	bottlenecks	bottleneck	NOUN
aiua-13762	287	29	(	(	PUNCT
aiua-13762	287	30	106	106	NUM
aiua-13762	287	31	)	)	PUNCT
aiua-13762	287	32	.	.	PUNCT
aiua-13762	288	1	these	these	DET
aiua-13762	288	2	historical	historical	ADJ
aiua-13762	288	3	phenomena	phenomenon	NOUN
aiua-13762	288	4	have	have	AUX
aiua-13762	288	5	contributed	contribute	VERB
aiua-13762	288	6	to	to	ADP
aiua-13762	288	7	the	the	DET
aiua-13762	288	8	emergence	emergence	NOUN
aiua-13762	288	9	of	of	ADP
aiua-13762	288	10	hereditary	hereditary	ADJ
aiua-13762	288	11	diseases	disease	NOUN
aiua-13762	288	12	,	,	PUNCT
aiua-13762	288	13	including	include	VERB
aiua-13762	288	14	familial	familial	ADJ
aiua-13762	288	15	forms	form	NOUN
aiua-13762	288	16	of	of	ADP
aiua-13762	288	17	cancer	cancer	NOUN
aiua-13762	288	18	such	such	ADJ
aiua-13762	288	19	as	as	ADP
aiua-13762	288	20	prostate	prostate	NOUN
aiua-13762	288	21	cancer	cancer	NOUN
aiua-13762	288	22	.	.	PUNCT
aiua-13762	289	1	this	this	DET
aiua-13762	289	2	review	review	NOUN
aiua-13762	289	3	article	article	NOUN
aiua-13762	289	4	summarized	summarize	VERB
aiua-13762	289	5	the	the	DET
aiua-13762	289	6	available	available	ADJ
aiua-13762	289	7	evidence	evidence	NOUN
aiua-13762	289	8	linking	link	VERB
aiua-13762	289	9	specific	specific	ADJ
aiua-13762	289	10	genetic	genetic	ADJ
aiua-13762	289	11	mutations	mutation	NOUN
aiua-13762	289	12	,	,	PUNCT
aiua-13762	289	13	expressed	express	VERB
aiua-13762	289	14	by	by	ADP
aiua-13762	289	15	aj	aj	PROPN
aiua-13762	289	16	,	,	PUNCT
aiua-13762	289	17	to	to	ADP
aiua-13762	289	18	the	the	DET
aiua-13762	289	19	heritability	heritability	NOUN
aiua-13762	289	20	,	,	PUNCT
aiua-13762	289	21	onset	onset	NOUN
aiua-13762	289	22	,	,	PUNCT
aiua-13762	289	23	and	and	CCONJ
aiua-13762	289	24	progression	progression	NOUN
aiua-13762	289	25	of	of	ADP
aiua-13762	289	26	prostate	prostate	NOUN
aiua-13762	289	27	cancer	cancer	NOUN
aiua-13762	289	28	.	.	PUNCT
aiua-13762	290	1	from	from	ADP
aiua-13762	290	2	the	the	DET
aiua-13762	290	3	evidence	evidence	NOUN
aiua-13762	290	4	produced	produce	VERB
aiua-13762	290	5	so	so	ADV
aiua-13762	290	6	far	far	ADV
aiua-13762	290	7	,	,	PUNCT
aiua-13762	290	8	it	it	PRON
aiua-13762	290	9	appears	appear	VERB
aiua-13762	290	10	that	that	SCONJ
aiua-13762	290	11	the	the	DET
aiua-13762	290	12	overall	overall	ADJ
aiua-13762	290	13	burden	burden	NOUN
aiua-13762	290	14	of	of	ADP
aiua-13762	290	15	prostate	prostate	NOUN
aiua-13762	290	16	cancer	cancer	NOUN
aiua-13762	290	17	may	may	AUX
aiua-13762	290	18	not	not	PART
aiua-13762	290	19	be	be	AUX
aiua-13762	290	20	considerably	considerably	ADV
aiua-13762	290	21	higher	high	ADJ
aiua-13762	290	22	in	in	ADP
aiua-13762	290	23	aj	aj	PROPN
aiua-13762	290	24	compared	compare	VERB
aiua-13762	290	25	to	to	ADP
aiua-13762	290	26	european	european	PROPN
aiua-13762	290	27	non	non	ADJ
aiua-13762	290	28	-	-	ADJ
aiua-13762	290	29	jewish	jewish	ADJ
aiua-13762	290	30	populations	population	NOUN
aiua-13762	290	31	(	(	PUNCT
aiua-13762	290	32	107	107	NUM
aiua-13762	290	33	)	)	PUNCT
aiua-13762	290	34	.	.	PUNCT
aiua-13762	291	1	furthermore	furthermore	ADV
aiua-13762	291	2	,	,	PUNCT
aiua-13762	291	3	ashkenazi	ashkenazi	ADJ
aiua-13762	291	4	founder	founder	NOUN
aiua-13762	291	5	mutations	mutation	NOUN
aiua-13762	291	6	do	do	AUX
aiua-13762	291	7	not	not	PART
aiua-13762	291	8	appear	appear	VERB
aiua-13762	291	9	to	to	PART
aiua-13762	291	10	be	be	AUX
aiua-13762	291	11	strongly	strongly	ADV
aiua-13762	291	12	associated	associate	VERB
aiua-13762	291	13	with	with	ADP
aiua-13762	291	14	early	early	ADJ
aiua-13762	291	15	-	-	PUNCT
aiua-13762	291	16	onset	onset	NOUN
aiua-13762	291	17	prostate	prostate	NOUN
aiua-13762	291	18	cancer	cancer	NOUN
aiua-13762	291	19	.	.	PUNCT
aiua-13762	292	1	however	however	ADV
aiua-13762	292	2	,	,	PUNCT
aiua-13762	292	3	substantial	substantial	ADJ
aiua-13762	292	4	evidence	evidence	NOUN
aiua-13762	292	5	supports	support	VERB
aiua-13762	292	6	a	a	DET
aiua-13762	292	7	link	link	NOUN
aiua-13762	292	8	between	between	ADP
aiua-13762	292	9	certain	certain	ADJ
aiua-13762	292	10	founder	founder	NOUN
aiua-13762	292	11	mutations	mutation	NOUN
aiua-13762	292	12	and	and	CCONJ
aiua-13762	292	13	an	an	DET
aiua-13762	292	14	increased	increase	VERB
aiua-13762	292	15	risk	risk	NOUN
aiua-13762	292	16	of	of	ADP
aiua-13762	292	17	developing	develop	VERB
aiua-13762	292	18	prostate	prostate	NOUN
aiua-13762	292	19	cancer	cancer	NOUN
aiua-13762	292	20	.	.	PUNCT
aiua-13762	293	1	notably	notably	ADV
aiua-13762	293	2	,	,	PUNCT
aiua-13762	293	3	the	the	DET
aiua-13762	293	4	6174delt	6174delt	NUM
aiua-13762	293	5	ashkenazi	ashkenazi	ADJ
aiua-13762	293	6	founder	founder	NOUN
aiua-13762	293	7	deletion	deletion	NOUN
aiua-13762	293	8	in	in	ADP
aiua-13762	293	9	brca2	brca2	PROPN
aiua-13762	293	10	has	have	AUX
aiua-13762	293	11	been	be	AUX
aiua-13762	293	12	consistently	consistently	ADV
aiua-13762	293	13	associated	associate	VERB
aiua-13762	293	14	with	with	ADP
aiua-13762	293	15	an	an	DET
aiua-13762	293	16	elevated	elevated	ADJ
aiua-13762	293	17	susceptibility	susceptibility	NOUN
aiua-13762	293	18	to	to	ADP
aiua-13762	293	19	prostate	prostate	NOUN
aiua-13762	293	20	cancer	cancer	NOUN
aiua-13762	293	21	.	.	PUNCT
aiua-13762	294	1	carriers	carrier	NOUN
aiua-13762	294	2	of	of	ADP
aiua-13762	294	3	this	this	DET
aiua-13762	294	4	mutation	mutation	NOUN
aiua-13762	294	5	also	also	ADV
aiua-13762	294	6	face	face	VERB
aiua-13762	294	7	an	an	DET
aiua-13762	294	8	increased	increase	VERB
aiua-13762	294	9	risk	risk	NOUN
aiua-13762	294	10	of	of	ADP
aiua-13762	294	11	high	high	ADJ
aiua-13762	294	12	-	-	PUNCT
aiua-13762	294	13	grade	grade	NOUN
aiua-13762	294	14	pca	pca	NOUN
aiua-13762	294	15	(	(	PUNCT
aiua-13762	294	16	gleason	gleason	PROPN
aiua-13762	294	17	score	score	VERB
aiua-13762	294	18	>	>	X
aiua-13762	294	19	7	7	NUM
aiua-13762	294	20	)	)	PUNCT
aiua-13762	294	21	,	,	PUNCT
aiua-13762	294	22	as	as	ADV
aiua-13762	294	23	well	well	ADV
aiua-13762	294	24	as	as	ADP
aiua-13762	294	25	higher	high	ADJ
aiua-13762	294	26	rates	rate	NOUN
aiua-13762	294	27	of	of	ADP
aiua-13762	294	28	castration	castration	NOUN
aiua-13762	294	29	-	-	PUNCT
aiua-13762	294	30	resistant	resistant	ADJ
aiua-13762	294	31	metastatic	metastatic	ADJ
aiua-13762	294	32	disease	disease	NOUN
aiua-13762	294	33	,	,	PUNCT
aiua-13762	294	34	biochemical	biochemical	ADJ
aiua-13762	294	35	recurrence	recurrence	NOUN
aiua-13762	294	36	,	,	PUNCT
aiua-13762	294	37	and	and	CCONJ
aiua-13762	294	38	mortality	mortality	NOUN
aiua-13762	294	39	when	when	SCONJ
aiua-13762	294	40	compared	compare	VERB
aiua-13762	294	41	to	to	ADP
aiua-13762	294	42	non	non	NOUN
aiua-13762	294	43	-	-	NOUN
aiua-13762	294	44	carriers	carrier	NOUN
aiua-13762	294	45	.	.	PUNCT
aiua-13762	295	1	mutations	mutation	NOUN
aiua-13762	295	2	in	in	ADP
aiua-13762	295	3	brca1	brca1	PROPN
aiua-13762	295	4	also	also	ADV
aiua-13762	295	5	appear	appear	VERB
aiua-13762	295	6	to	to	PART
aiua-13762	295	7	be	be	AUX
aiua-13762	295	8	linked	link	VERB
aiua-13762	295	9	to	to	ADP
aiua-13762	295	10	pca	pca	PROPN
aiua-13762	295	11	,	,	PUNCT
aiua-13762	295	12	albeit	albeit	SCONJ
aiua-13762	295	13	to	to	ADP
aiua-13762	295	14	a	a	DET
aiua-13762	295	15	lesser	less	ADJ
aiua-13762	295	16	extent	extent	NOUN
aiua-13762	295	17	.	.	PUNCT
aiua-13762	296	1	several	several	ADJ
aiua-13762	296	2	findings	finding	NOUN
aiua-13762	296	3	reviewed	review	VERB
aiua-13762	296	4	in	in	ADP
aiua-13762	296	5	this	this	DET
aiua-13762	296	6	article	article	NOUN
aiua-13762	296	7	underscore	underscore	VERB
aiua-13762	296	8	the	the	DET
aiua-13762	296	9	potential	potential	ADJ
aiua-13762	296	10	benefit	benefit	NOUN
aiua-13762	296	11	of	of	ADP
aiua-13762	296	12	genetic	genetic	ADJ
aiua-13762	296	13	screening	screening	NOUN
aiua-13762	296	14	for	for	ADP
aiua-13762	296	15	prostate	prostate	NOUN
aiua-13762	296	16	cancer	cancer	NOUN
aiua-13762	296	17	risk	risk	NOUN
aiua-13762	296	18	in	in	ADP
aiua-13762	296	19	ashkenazi	ashkenazi	ADJ
aiua-13762	296	20	jewish	jewish	ADJ
aiua-13762	296	21	men	man	NOUN
aiua-13762	296	22	,	,	PUNCT
aiua-13762	296	23	especially	especially	ADV
aiua-13762	296	24	considering	consider	VERB
aiua-13762	296	25	the	the	DET
aiua-13762	296	26	high	high	ADJ
aiua-13762	296	27	degree	degree	NOUN
aiua-13762	296	28	of	of	ADP
aiua-13762	296	29	endogamy	endogamy	NOUN
aiua-13762	296	30	observed	observe	VERB
aiua-13762	296	31	within	within	ADP
aiua-13762	296	32	certain	certain	ADJ
aiua-13762	296	33	subgroups	subgroup	NOUN
aiua-13762	296	34	of	of	ADP
aiua-13762	296	35	this	this	DET
aiua-13762	296	36	population	population	NOUN
aiua-13762	296	37	,	,	PUNCT
aiua-13762	296	38	such	such	ADJ
aiua-13762	296	39	as	as	ADP
aiua-13762	296	40	the	the	DET
aiua-13762	296	41	“	"	PUNCT
aiua-13762	296	42	haredim	haredim	PROPN
aiua-13762	296	43	”	"	PUNCT
aiua-13762	296	44	(	(	PUNCT
aiua-13762	296	45	a	a	DET
aiua-13762	296	46	hebrew	hebrew	ADJ
aiua-13762	296	47	term	term	NOUN
aiua-13762	296	48	for	for	ADP
aiua-13762	296	49	the	the	DET
aiua-13762	296	50	“	"	PUNCT
aiua-13762	296	51	fearful	fearful	ADJ
aiua-13762	296	52	”	"	PUNCT
aiua-13762	296	53	,	,	PUNCT
aiua-13762	296	54	i.e.	i.e.	X
aiua-13762	296	55	the	the	DET
aiua-13762	296	56	very	very	ADV
aiua-13762	296	57	religious	religious	ADJ
aiua-13762	296	58	communities	community	NOUN
aiua-13762	296	59	)	)	PUNCT
aiua-13762	296	60	(	(	PUNCT
aiua-13762	296	61	108	108	NUM
aiua-13762	296	62	)	)	PUNCT
aiua-13762	296	63	.	.	PUNCT
aiua-13762	297	1	on	on	ADP
aiua-13762	297	2	the	the	DET
aiua-13762	297	3	other	other	ADJ
aiua-13762	297	4	side	side	NOUN
aiua-13762	297	5	,	,	PUNCT
aiua-13762	297	6	contemporary	contemporary	ADJ
aiua-13762	297	7	israeli	israeli	ADJ
aiua-13762	297	8	society	society	PROPN
aiua-13762	297	9	and	and	CCONJ
aiua-13762	297	10	diaspora	diaspora	PROPN
aiua-13762	297	11	jewish	jewish	ADJ
aiua-13762	297	12	communities	community	NOUN
aiua-13762	297	13	have	have	AUX
aiua-13762	297	14	experienced	experience	VERB
aiua-13762	297	15	growing	grow	VERB
aiua-13762	297	16	intermarriage	intermarriage	NOUN
aiua-13762	297	17	rates	rate	NOUN
aiua-13762	297	18	—	—	PUNCT
aiua-13762	297	19	both	both	CCONJ
aiua-13762	297	20	among	among	ADP
aiua-13762	297	21	ashkenazim	ashkenazim	PROPN
aiua-13762	297	22	and	and	CCONJ
aiua-13762	297	23	non	non	PROPN
aiua-13762	297	24	-	-	PROPN
aiua-13762	297	25	aj	aj	PROPN
aiua-13762	297	26	in	in	ADP
aiua-13762	297	27	israel	israel	PROPN
aiua-13762	297	28	,	,	PUNCT
aiua-13762	297	29	and	and	CCONJ
aiua-13762	297	30	between	between	ADP
aiua-13762	297	31	jews	jews	PROPN
aiua-13762	297	32	and	and	CCONJ
aiua-13762	297	33	non	non	NOUN
aiua-13762	297	34	-	-	NOUN
aiua-13762	297	35	jews	jews	PROPN
aiua-13762	297	36	in	in	ADP
aiua-13762	297	37	the	the	DET
aiua-13762	297	38	diaspora	diaspora	NOUN
aiua-13762	297	39	(	(	PUNCT
aiua-13762	297	40	109	109	NUM
aiua-13762	297	41	)	)	PUNCT
aiua-13762	297	42	.	.	PUNCT
aiua-13762	298	1	this	this	DET
aiua-13762	298	2	trend	trend	NOUN
aiua-13762	298	3	may	may	AUX
aiua-13762	298	4	serve	serve	VERB
aiua-13762	298	5	to	to	PART
aiua-13762	298	6	“	"	PUNCT
aiua-13762	298	7	dilute	dilute	VERB
aiua-13762	298	8	”	"	PUNCT
aiua-13762	298	9	the	the	DET
aiua-13762	298	10	negative	negative	ADJ
aiua-13762	298	11	effects	effect	NOUN
aiua-13762	298	12	of	of	ADP
aiua-13762	298	13	endogamy	endogamy	NOUN
aiua-13762	298	14	over	over	ADP
aiua-13762	298	15	time	time	NOUN
aiua-13762	298	16	,	,	PUNCT
aiua-13762	298	17	potentially	potentially	ADV
aiua-13762	298	18	reducing	reduce	VERB
aiua-13762	298	19	the	the	DET
aiua-13762	298	20	long	long	ADJ
aiua-13762	298	21	-	-	PUNCT
aiua-13762	298	22	term	term	NOUN
aiua-13762	298	23	risk	risk	NOUN
aiua-13762	298	24	of	of	ADP
aiua-13762	298	25	hereditary	hereditary	ADJ
aiua-13762	298	26	diseases	disease	NOUN
aiua-13762	298	27	.	.	PUNCT
aiua-13762	299	1	however	however	ADV
aiua-13762	299	2	,	,	PUNCT
aiua-13762	299	3	within	within	ADP
aiua-13762	299	4	the	the	DET
aiua-13762	299	5	highly	highly	ADV
aiua-13762	299	6	segregated	segregated	ADJ
aiua-13762	299	7	“	"	PUNCT
aiua-13762	299	8	haredi	haredi	PROPN
aiua-13762	299	9	”	"	PUNCT
aiua-13762	299	10	communities	community	NOUN
aiua-13762	299	11	in	in	ADP
aiua-13762	299	12	israel	israel	PROPN
aiua-13762	299	13	and	and	CCONJ
aiua-13762	299	14	in	in	ADP
aiua-13762	299	15	the	the	DET
aiua-13762	299	16	diaspora	diaspora	PROPN
aiua-13762	299	17	,	,	PUNCT
aiua-13762	299	18	strict	strict	ADJ
aiua-13762	299	19	endogamy	endogamy	NOUN
aiua-13762	299	20	is	be	AUX
aiua-13762	299	21	maintained	maintain	VERB
aiua-13762	299	22	not	not	PART
aiua-13762	299	23	only	only	ADV
aiua-13762	299	24	within	within	ADP
aiua-13762	299	25	the	the	DET
aiua-13762	299	26	jewish	jewish	ADJ
aiua-13762	299	27	religious	religious	ADJ
aiua-13762	299	28	-	-	PUNCT
aiua-13762	299	29	cultural	cultural	ADJ
aiua-13762	299	30	group	group	NOUN
aiua-13762	299	31	at	at	ADP
aiua-13762	299	32	large	large	ADJ
aiua-13762	299	33	,	,	PUNCT
aiua-13762	299	34	but	but	CCONJ
aiua-13762	299	35	more	more	ADV
aiua-13762	299	36	specifically	specifically	ADV
aiua-13762	299	37	within	within	ADP
aiua-13762	299	38	smaller	small	ADJ
aiua-13762	299	39	ashkenazi	ashkenazi	ADJ
aiua-13762	299	40	subgroups	subgroup	NOUN
aiua-13762	299	41	(	(	PUNCT
aiua-13762	299	42	“	"	PUNCT
aiua-13762	299	43	hatzerot	hatzerot	PROPN
aiua-13762	299	44	”	"	PUNCT
aiua-13762	299	45	)	)	PUNCT
aiua-13762	299	46	which	which	PRON
aiua-13762	299	47	are	be	AUX
aiua-13762	299	48	linked	link	VERB
aiua-13762	299	49	by	by	ADP
aiua-13762	299	50	specific	specific	ADJ
aiua-13762	299	51	extended	extended	ADJ
aiua-13762	299	52	families	family	NOUN
aiua-13762	299	53	or	or	CCONJ
aiua-13762	299	54	geographical	geographical	ADJ
aiua-13762	299	55	ancestries	ancestry	NOUN
aiua-13762	299	56	.	.	PUNCT
aiua-13762	300	1	in	in	ADP
aiua-13762	300	2	these	these	DET
aiua-13762	300	3	cases	case	NOUN
aiua-13762	300	4	,	,	PUNCT
aiua-13762	300	5	the	the	DET
aiua-13762	300	6	risks	risk	NOUN
aiua-13762	300	7	of	of	ADP
aiua-13762	300	8	genetic	genetic	ADJ
aiua-13762	300	9	disease	disease	NOUN
aiua-13762	300	10	transmission	transmission	NOUN
aiua-13762	300	11	may	may	AUX
aiua-13762	300	12	tend	tend	VERB
aiua-13762	300	13	to	to	PART
aiua-13762	300	14	substantially	substantially	ADV
aiua-13762	300	15	increase	increase	VERB
aiua-13762	300	16	.	.	PUNCT
aiua-13762	301	1	public	public	ADJ
aiua-13762	301	2	health	health	NOUN
aiua-13762	301	3	implications	implication	NOUN
aiua-13762	301	4	and	and	CCONJ
aiua-13762	301	5	further	further	ADJ
aiua-13762	301	6	research	research	VERB
aiua-13762	301	7	the	the	DET
aiua-13762	301	8	clinical	clinical	ADJ
aiua-13762	301	9	implications	implication	NOUN
aiua-13762	301	10	of	of	ADP
aiua-13762	301	11	identifying	identify	VERB
aiua-13762	301	12	cancer	cancer	NOUN
aiua-13762	301	13	-	-	PUNCT
aiua-13762	301	14	predisposing	predispose	VERB
aiua-13762	301	15	mutations	mutation	NOUN
aiua-13762	301	16	for	for	ADP
aiua-13762	301	17	patient	patient	ADJ
aiua-13762	301	18	prognosis	prognosis	NOUN
aiua-13762	301	19	and	and	CCONJ
aiua-13762	301	20	treatment	treatment	NOUN
aiua-13762	301	21	remain	remain	VERB
aiua-13762	301	22	an	an	DET
aiua-13762	301	23	open	open	ADJ
aiua-13762	301	24	question	question	NOUN
aiua-13762	301	25	.	.	PUNCT
aiua-13762	302	1	further	further	ADJ
aiua-13762	302	2	research	research	NOUN
aiua-13762	302	3	is	be	AUX
aiua-13762	302	4	needed	need	VERB
aiua-13762	302	5	to	to	PART
aiua-13762	302	6	explore	explore	VERB
aiua-13762	302	7	the	the	DET
aiua-13762	302	8	potential	potential	ADJ
aiua-13762	302	9	applications	application	NOUN
aiua-13762	302	10	of	of	ADP
aiua-13762	302	11	genetic	genetic	ADJ
aiua-13762	302	12	information	information	NOUN
aiua-13762	302	13	for	for	ADP
aiua-13762	302	14	personalized	personalize	VERB
aiua-13762	302	15	therapeutic	therapeutic	ADJ
aiua-13762	302	16	strategies	strategy	NOUN
aiua-13762	302	17	and	and	CCONJ
aiua-13762	302	18	risk	risk	NOUN
aiua-13762	302	19	stratification	stratification	NOUN
aiua-13762	302	20	.	.	PUNCT
aiua-13762	303	1	as	as	ADP
aiua-13762	303	2	a	a	DET
aiua-13762	303	3	general	general	ADJ
aiua-13762	303	4	caveat	caveat	NOUN
aiua-13762	303	5	,	,	PUNCT
aiua-13762	303	6	we	we	PRON
aiua-13762	303	7	caution	caution	VERB
aiua-13762	303	8	against	against	ADP
aiua-13762	303	9	over	over	ADP
aiua-13762	303	10	-	-	PUNCT
aiua-13762	303	11	interpreting	interpret	VERB
aiua-13762	303	12	variations	variation	NOUN
aiua-13762	303	13	in	in	ADP
aiua-13762	303	14	cancer	cancer	NOUN
aiua-13762	303	15	rates	rate	NOUN
aiua-13762	303	16	between	between	ADP
aiua-13762	303	17	ethnic	ethnic	ADJ
aiua-13762	303	18	groups	group	NOUN
aiua-13762	303	19	,	,	PUNCT
aiua-13762	303	20	emphasizing	emphasize	VERB
aiua-13762	303	21	the	the	DET
aiua-13762	303	22	need	need	NOUN
aiua-13762	303	23	for	for	ADP
aiua-13762	303	24	careful	careful	ADJ
aiua-13762	303	25	consideration	consideration	NOUN
aiua-13762	303	26	of	of	ADP
aiua-13762	303	27	public	public	ADJ
aiua-13762	303	28	health	health	NOUN
aiua-13762	303	29	implications	implication	NOUN
aiua-13762	303	30	.	.	PUNCT
aiua-13762	304	1	in	in	ADP
aiua-13762	304	2	this	this	DET
aiua-13762	304	3	respect	respect	NOUN
aiua-13762	304	4	,	,	PUNCT
aiua-13762	304	5	the	the	DET
aiua-13762	304	6	possible	possible	ADJ
aiua-13762	304	7	presence	presence	NOUN
aiua-13762	304	8	of	of	ADP
aiua-13762	304	9	diagnostic	diagnostic	ADJ
aiua-13762	304	10	bias	bias	NOUN
aiua-13762	304	11	in	in	ADP
aiua-13762	304	12	populations	population	NOUN
aiua-13762	304	13	with	with	ADP
aiua-13762	304	14	high	high	ADJ
aiua-13762	304	15	rates	rate	NOUN
aiua-13762	304	16	of	of	ADP
aiua-13762	304	17	familial	familial	ADJ
aiua-13762	304	18	cancers	cancer	NOUN
aiua-13762	304	19	should	should	AUX
aiua-13762	304	20	be	be	AUX
aiua-13762	304	21	considered	consider	VERB
aiua-13762	304	22	,	,	PUNCT
aiua-13762	304	23	as	as	SCONJ
aiua-13762	304	24	increased	increase	VERB
aiua-13762	304	25	preventive	preventive	ADJ
aiua-13762	304	26	screening	screening	NOUN
aiua-13762	304	27	may	may	AUX
aiua-13762	304	28	lead	lead	VERB
aiua-13762	304	29	to	to	ADP
aiua-13762	304	30	the	the	DET
aiua-13762	304	31	detection	detection	NOUN
aiua-13762	304	32	of	of	ADP
aiua-13762	304	33	previously	previously	ADV
aiua-13762	304	34	undiagnosed	undiagnosed	ADJ
aiua-13762	304	35	,	,	PUNCT
aiua-13762	304	36	low	low	ADJ
aiua-13762	304	37	-	-	PUNCT
aiua-13762	304	38	risk	risk	NOUN
aiua-13762	304	39	or	or	CCONJ
aiua-13762	304	40	indolent	indolent	ADJ
aiua-13762	304	41	prostate	prostate	NOUN
aiua-13762	304	42	cancers	cancer	NOUN
aiua-13762	304	43	.	.	PUNCT
aiua-13762	305	1	given	give	VERB
aiua-13762	305	2	the	the	DET
aiua-13762	305	3	indolent	indolent	ADJ
aiua-13762	305	4	and	and	CCONJ
aiua-13762	305	5	often	often	ADV
aiua-13762	305	6	asymptomatic	asymptomatic	ADJ
aiua-13762	305	7	nature	nature	NOUN
aiua-13762	305	8	of	of	ADP
aiua-13762	305	9	certain	certain	ADJ
aiua-13762	305	10	forms	form	NOUN
aiua-13762	305	11	of	of	ADP
aiua-13762	305	12	prostate	prostate	NOUN
aiua-13762	305	13	cancer	cancer	NOUN
aiua-13762	305	14	,	,	PUNCT
aiua-13762	305	15	it	it	PRON
aiua-13762	305	16	is	be	AUX
aiua-13762	305	17	essential	essential	ADJ
aiua-13762	305	18	to	to	PART
aiua-13762	305	19	raise	raise	VERB
aiua-13762	305	20	awareness	awareness	NOUN
aiua-13762	305	21	among	among	ADP
aiua-13762	305	22	ashkenazi	ashkenazi	ADJ
aiua-13762	305	23	men	man	NOUN
aiua-13762	305	24	and	and	CCONJ
aiua-13762	305	25	healthcare	healthcare	NOUN
aiua-13762	305	26	providers	provider	NOUN
aiua-13762	305	27	,	,	PUNCT
aiua-13762	305	28	as	as	SCONJ
aiua-13762	305	29	early	early	ADJ
aiua-13762	305	30	detection	detection	NOUN
aiua-13762	305	31	through	through	ADP
aiua-13762	305	32	proactive	proactive	ADJ
aiua-13762	305	33	screening	screening	NOUN
aiua-13762	305	34	is	be	AUX
aiua-13762	305	35	crucial	crucial	ADJ
aiua-13762	305	36	in	in	ADP
aiua-13762	305	37	contrast	contrast	NOUN
aiua-13762	305	38	to	to	ADP
aiua-13762	305	39	other	other	ADJ
aiua-13762	305	40	tumors	tumor	NOUN
aiua-13762	305	41	,	,	PUNCT
aiua-13762	305	42	such	such	ADJ
aiua-13762	305	43	as	as	ADP
aiua-13762	305	44	bladder	bladder	NOUN
aiua-13762	305	45	cancer	cancer	NOUN
aiua-13762	305	46	,	,	PUNCT
aiua-13762	305	47	that	that	PRON
aiua-13762	305	48	tend	tend	VERB
aiua-13762	305	49	to	to	PART
aiua-13762	305	50	present	present	VERB
aiua-13762	305	51	with	with	ADP
aiua-13762	305	52	more	more	ADV
aiua-13762	305	53	symptomatic	symptomatic	ADJ
aiua-13762	305	54	features	feature	NOUN
aiua-13762	305	55	at	at	ADP
aiua-13762	305	56	earlier	early	ADJ
aiua-13762	305	57	stages	stage	NOUN
aiua-13762	305	58	.	.	PUNCT
aiua-13762	306	1	archivio	archivio	NOUN
aiua-13762	306	2	italiano	italiano	X
aiua-13762	306	3	di	di	PROPN
aiua-13762	306	4	urologia	urologia	PROPN
aiua-13762	306	5	e	e	PROPN
aiua-13762	306	6	andrologia	andrologia	NOUN
aiua-13762	306	7	2025	2025	NUM
aiua-13762	306	8	;	;	PUNCT
aiua-13762	306	9	97(2):13762	97(2):13762	NUM
aiua-13762	306	10	g.	g.	PROPN
aiua-13762	306	11	perletti	perletti	PROPN
aiua-13762	306	12	,	,	PUNCT
aiua-13762	306	13	d.	d.	PROPN
aiua-13762	306	14	cohen	cohen	PROPN
aiua-13762	306	15	hattab	hattab	PROPN
aiua-13762	306	16	,	,	PUNCT
aiua-13762	306	17	s.	s.	PROPN
aiua-13762	306	18	dellapergola	dellapergola	PROPN
aiua-13762	306	19	,	,	PUNCT
aiua-13762	306	20	et	et	PROPN
aiua-13762	306	21	al	al	PROPN
aiua-13762	306	22	.	.	PROPN
aiua-13762	307	1	10	10	NUM
aiua-13762	307	2	unresolved	unresolved	ADJ
aiua-13762	307	3	issues	issue	NOUN
aiua-13762	307	4	the	the	DET
aiua-13762	307	5	role	role	NOUN
aiua-13762	307	6	of	of	ADP
aiua-13762	307	7	non	non	ADJ
aiua-13762	307	8	-	-	ADJ
aiua-13762	307	9	brca	brca	ADJ
aiua-13762	307	10	mutations	mutation	NOUN
aiua-13762	307	11	contributing	contribute	VERB
aiua-13762	307	12	to	to	ADP
aiua-13762	307	13	pca	pca	PROPN
aiua-13762	307	14	in	in	ADP
aiua-13762	307	15	aj	aj	PROPN
aiua-13762	307	16	remains	remain	VERB
aiua-13762	307	17	unclear	unclear	ADJ
aiua-13762	307	18	and	and	CCONJ
aiua-13762	307	19	demands	demand	VERB
aiua-13762	307	20	further	further	ADJ
aiua-13762	307	21	investigation	investigation	NOUN
aiua-13762	307	22	.	.	PUNCT
aiua-13762	308	1	additional	additional	ADJ
aiua-13762	308	2	evidence	evidence	NOUN
aiua-13762	308	3	is	be	AUX
aiua-13762	308	4	needed	need	VERB
aiua-13762	308	5	before	before	ADP
aiua-13762	308	6	drawing	draw	VERB
aiua-13762	308	7	definitive	definitive	ADJ
aiua-13762	308	8	conclusions	conclusion	NOUN
aiua-13762	308	9	about	about	ADP
aiua-13762	308	10	the	the	DET
aiua-13762	308	11	risks	risk	NOUN
aiua-13762	308	12	associated	associate	VERB
aiua-13762	308	13	with	with	ADP
aiua-13762	308	14	mutations	mutation	NOUN
aiua-13762	308	15	such	such	ADJ
aiua-13762	308	16	as	as	ADP
aiua-13762	308	17	471delaaag	471delaaag	PROPN
aiua-13762	308	18	in	in	ADP
aiua-13762	308	19	rnasel	rnasel	NOUN
aiua-13762	308	20	or	or	CCONJ
aiua-13762	308	21	i1307k	i1307k	NOUN
aiua-13762	308	22	in	in	ADP
aiua-13762	308	23	apc	apc	PROPN
aiua-13762	308	24	.	.	PUNCT
aiua-13762	309	1	as	as	SCONJ
aiua-13762	309	2	noted	note	VERB
aiua-13762	309	3	by	by	ADP
aiua-13762	309	4	agalliu	agalliu	PROPN
aiua-13762	309	5	et	et	PROPN
aiua-13762	309	6	al	al	PROPN
aiua-13762	309	7	.	.	PUNCT
aiua-13762	310	1	(	(	PUNCT
aiua-13762	310	2	46	46	NUM
aiua-13762	310	3	,	,	PUNCT
aiua-13762	310	4	64	64	NUM
aiua-13762	310	5	)	)	PUNCT
aiua-13762	310	6	,	,	PUNCT
aiua-13762	310	7	inconsistent	inconsistent	ADJ
aiua-13762	310	8	results	result	NOUN
aiua-13762	310	9	across	across	ADP
aiua-13762	310	10	studies	study	NOUN
aiua-13762	310	11	may	may	AUX
aiua-13762	310	12	be	be	AUX
aiua-13762	310	13	attributed	attribute	VERB
aiua-13762	310	14	to	to	ADP
aiua-13762	310	15	factors	factor	NOUN
aiua-13762	310	16	such	such	ADJ
aiua-13762	310	17	as	as	ADP
aiua-13762	310	18	small	small	ADJ
aiua-13762	310	19	sample	sample	NOUN
aiua-13762	310	20	sizes	size	NOUN
aiua-13762	310	21	,	,	PUNCT
aiua-13762	310	22	low	low	ADJ
aiua-13762	310	23	statistical	statistical	ADJ
aiua-13762	310	24	power	power	NOUN
aiua-13762	310	25	,	,	PUNCT
aiua-13762	310	26	false	false	ADJ
aiua-13762	310	27	-	-	PUNCT
aiua-13762	310	28	positive	positive	ADJ
aiua-13762	310	29	findings	finding	NOUN
aiua-13762	310	30	,	,	PUNCT
aiua-13762	310	31	genetic	genetic	ADJ
aiua-13762	310	32	heterogeneity	heterogeneity	NOUN
aiua-13762	310	33	in	in	ADP
aiua-13762	310	34	prostate	prostate	NOUN
aiua-13762	310	35	cancer	cancer	NOUN
aiua-13762	310	36	,	,	PUNCT
aiua-13762	310	37	or	or	CCONJ
aiua-13762	310	38	errors	error	NOUN
aiua-13762	310	39	in	in	ADP
aiua-13762	310	40	distinguishing	distinguish	VERB
aiua-13762	310	41	hereditary	hereditary	ADJ
aiua-13762	310	42	,	,	PUNCT
aiua-13762	310	43	familial	familial	ADJ
aiua-13762	310	44	,	,	PUNCT
aiua-13762	310	45	and	and	CCONJ
aiua-13762	310	46	sporadic	sporadic	ADJ
aiua-13762	310	47	forms	form	NOUN
aiua-13762	310	48	of	of	ADP
aiua-13762	310	49	the	the	DET
aiua-13762	310	50	disease	disease	NOUN
aiua-13762	310	51	.	.	PUNCT
aiua-13762	311	1	the	the	DET
aiua-13762	311	2	identification	identification	NOUN
aiua-13762	311	3	of	of	ADP
aiua-13762	311	4	highly	highly	ADV
aiua-13762	311	5	penetrant	penetrant	ADJ
aiua-13762	311	6	genetic	genetic	ADJ
aiua-13762	311	7	markers	marker	NOUN
aiua-13762	311	8	for	for	ADP
aiua-13762	311	9	prostate	prostate	NOUN
aiua-13762	311	10	cancer	cancer	NOUN
aiua-13762	311	11	is	be	AUX
aiua-13762	311	12	more	more	ADV
aiua-13762	311	13	complex	complex	ADJ
aiua-13762	311	14	than	than	ADP
aiua-13762	311	15	for	for	ADP
aiua-13762	311	16	other	other	ADJ
aiua-13762	311	17	common	common	ADJ
aiua-13762	311	18	cancers	cancer	NOUN
aiua-13762	311	19	due	due	ADP
aiua-13762	311	20	to	to	ADP
aiua-13762	311	21	a	a	DET
aiua-13762	311	22	variety	variety	NOUN
aiua-13762	311	23	of	of	ADP
aiua-13762	311	24	factors	factor	NOUN
aiua-13762	311	25	.	.	PUNCT
aiua-13762	312	1	prostate	prostate	NOUN
aiua-13762	312	2	cancer	cancer	NOUN
aiua-13762	312	3	is	be	AUX
aiua-13762	312	4	often	often	ADV
aiua-13762	312	5	diagnosed	diagnose	VERB
aiua-13762	312	6	at	at	ADP
aiua-13762	312	7	an	an	DET
aiua-13762	312	8	older	old	ADJ
aiua-13762	312	9	age	age	NOUN
aiua-13762	312	10	,	,	PUNCT
aiua-13762	312	11	compared	compare	VERB
aiua-13762	312	12	–	–	PUNCT
aiua-13762	312	13	for	for	ADP
aiua-13762	312	14	instance	instance	NOUN
aiua-13762	312	15	–	–	PUNCT
aiua-13762	312	16	to	to	ADP
aiua-13762	312	17	early	early	ADJ
aiua-13762	312	18	-	-	PUNCT
aiua-13762	312	19	onset	onset	NOUN
aiua-13762	312	20	,	,	PUNCT
aiua-13762	312	21	brca	brca	PROPN
aiua-13762	312	22	-	-	PUNCT
aiua-13762	312	23	linked	link	VERB
aiua-13762	312	24	breast	breast	NOUN
aiua-13762	312	25	cancer	cancer	NOUN
aiua-13762	312	26	,	,	PUNCT
aiua-13762	312	27	making	make	VERB
aiua-13762	312	28	it	it	PRON
aiua-13762	312	29	difficult	difficult	ADJ
aiua-13762	312	30	to	to	PART
aiua-13762	312	31	obtain	obtain	VERB
aiua-13762	312	32	multi	multi	ADJ
aiua-13762	312	33	-	-	ADJ
aiua-13762	312	34	generational	generational	ADJ
aiua-13762	312	35	dna	dna	NOUN
aiua-13762	312	36	samples	sample	NOUN
aiua-13762	312	37	from	from	ADP
aiua-13762	312	38	affected	affected	ADJ
aiua-13762	312	39	individuals	individual	NOUN
aiua-13762	312	40	.	.	PUNCT
aiua-13762	313	1	furthermore	furthermore	ADV
aiua-13762	313	2	,	,	PUNCT
aiua-13762	313	3	the	the	DET
aiua-13762	313	4	diversity	diversity	NOUN
aiua-13762	313	5	of	of	ADP
aiua-13762	313	6	mutations	mutation	NOUN
aiua-13762	313	7	observed	observe	VERB
aiua-13762	313	8	in	in	ADP
aiua-13762	313	9	ashkenazi	ashkenazi	ADJ
aiua-13762	313	10	populations	population	NOUN
aiua-13762	313	11	also	also	ADV
aiua-13762	313	12	complicates	complicate	VERB
aiua-13762	313	13	our	our	PRON
aiua-13762	313	14	understanding	understanding	NOUN
aiua-13762	313	15	of	of	ADP
aiua-13762	313	16	how	how	SCONJ
aiua-13762	313	17	these	these	DET
aiua-13762	313	18	genetic	genetic	ADJ
aiua-13762	313	19	variants	variant	NOUN
aiua-13762	313	20	influence	influence	NOUN
aiua-13762	313	21	prostate	prostate	NOUN
aiua-13762	313	22	cancer	cancer	NOUN
aiua-13762	313	23	biology	biology	NOUN
aiua-13762	313	24	and	and	CCONJ
aiua-13762	313	25	patient	patient	ADJ
aiua-13762	313	26	outcomes	outcome	NOUN
aiua-13762	313	27	.	.	PUNCT
aiua-13762	314	1	variability	variability	NOUN
aiua-13762	314	2	in	in	ADP
aiua-13762	314	3	mutations	mutation	NOUN
aiua-13762	314	4	and	and	CCONJ
aiua-13762	314	5	their	their	PRON
aiua-13762	314	6	functional	functional	ADJ
aiua-13762	314	7	consequences	consequence	NOUN
aiua-13762	314	8	underscores	underscore	VERB
aiua-13762	314	9	the	the	DET
aiua-13762	314	10	complexity	complexity	NOUN
aiua-13762	314	11	of	of	ADP
aiua-13762	314	12	prostate	prostate	NOUN
aiua-13762	314	13	cancer	cancer	NOUN
aiua-13762	314	14	in	in	ADP
aiua-13762	314	15	this	this	DET
aiua-13762	314	16	population	population	NOUN
aiua-13762	314	17	.	.	PUNCT
aiua-13762	315	1	in	in	ADP
aiua-13762	315	2	addition	addition	NOUN
aiua-13762	315	3	,	,	PUNCT
aiua-13762	315	4	high	high	ADJ
aiua-13762	315	5	-	-	PUNCT
aiua-13762	315	6	risk	risk	NOUN
aiua-13762	315	7	pedigrees	pedigree	NOUN
aiua-13762	315	8	may	may	AUX
aiua-13762	315	9	include	include	VERB
aiua-13762	315	10	phenocopies	phenocopie	NOUN
aiua-13762	315	11	,	,	PUNCT
aiua-13762	315	12	i.e.	i.e.	X
aiua-13762	315	13	,	,	PUNCT
aiua-13762	315	14	sporadic	sporadic	ADJ
aiua-13762	315	15	pca	pca	NOUN
aiua-13762	315	16	cases	case	NOUN
aiua-13762	315	17	that	that	PRON
aiua-13762	315	18	may	may	AUX
aiua-13762	315	19	act	act	VERB
aiua-13762	315	20	as	as	ADP
aiua-13762	315	21	confounders	confounder	NOUN
aiua-13762	315	22	and	and	CCONJ
aiua-13762	315	23	complicate	complicate	VERB
aiua-13762	315	24	the	the	DET
aiua-13762	315	25	distinction	distinction	NOUN
aiua-13762	315	26	between	between	ADP
aiua-13762	315	27	familial	familial	ADJ
aiua-13762	315	28	and	and	CCONJ
aiua-13762	315	29	non	non	ADJ
aiua-13762	315	30	-	-	ADJ
aiua-13762	315	31	hereditary	hereditary	ADJ
aiua-13762	315	32	forms	form	NOUN
aiua-13762	315	33	.	.	PUNCT
aiua-13762	316	1	it	it	PRON
aiua-13762	316	2	should	should	AUX
aiua-13762	316	3	also	also	ADV
aiua-13762	316	4	be	be	AUX
aiua-13762	316	5	taken	take	VERB
aiua-13762	316	6	into	into	ADP
aiua-13762	316	7	consideration	consideration	NOUN
aiua-13762	316	8	that	that	SCONJ
aiua-13762	316	9	certain	certain	ADJ
aiua-13762	316	10	mutations	mutation	NOUN
aiua-13762	316	11	may	may	AUX
aiua-13762	316	12	act	act	VERB
aiua-13762	316	13	as	as	ADP
aiua-13762	316	14	risk	risk	NOUN
aiua-13762	316	15	modifiers	modifier	NOUN
aiua-13762	316	16	,	,	PUNCT
aiua-13762	316	17	contributing	contribute	VERB
aiua-13762	316	18	to	to	ADP
aiua-13762	316	19	disease	disease	NOUN
aiua-13762	316	20	susceptibility	susceptibility	NOUN
aiua-13762	316	21	in	in	ADP
aiua-13762	316	22	combination	combination	NOUN
aiua-13762	316	23	with	with	ADP
aiua-13762	316	24	other	other	ADJ
aiua-13762	316	25	genetic	genetic	ADJ
aiua-13762	316	26	factors	factor	NOUN
aiua-13762	316	27	rather	rather	ADV
aiua-13762	316	28	than	than	ADP
aiua-13762	316	29	as	as	ADP
aiua-13762	316	30	dominant	dominant	ADJ
aiua-13762	316	31	determinants	determinant	NOUN
aiua-13762	316	32	.	.	PUNCT
aiua-13762	317	1	in	in	ADP
aiua-13762	317	2	families	family	NOUN
aiua-13762	317	3	with	with	ADP
aiua-13762	317	4	a	a	DET
aiua-13762	317	5	strong	strong	ADJ
aiua-13762	317	6	history	history	NOUN
aiua-13762	317	7	of	of	ADP
aiua-13762	317	8	prostate	prostate	NOUN
aiua-13762	317	9	cancer	cancer	NOUN
aiua-13762	317	10	,	,	PUNCT
aiua-13762	317	11	the	the	DET
aiua-13762	317	12	disease	disease	NOUN
aiua-13762	317	13	may	may	AUX
aiua-13762	317	14	result	result	VERB
aiua-13762	317	15	from	from	ADP
aiua-13762	317	16	a	a	DET
aiua-13762	317	17	combination	combination	NOUN
aiua-13762	317	18	of	of	ADP
aiua-13762	317	19	multiple	multiple	ADJ
aiua-13762	317	20	mutations	mutation	NOUN
aiua-13762	317	21	with	with	ADP
aiua-13762	317	22	moderate	moderate	ADJ
aiua-13762	317	23	/	/	SYM
aiua-13762	317	24	low	low	ADJ
aiua-13762	317	25	penetrance	penetrance	NOUN
aiua-13762	317	26	rather	rather	ADV
aiua-13762	317	27	than	than	ADP
aiua-13762	317	28	a	a	DET
aiua-13762	317	29	single	single	ADJ
aiua-13762	317	30	high	high	ADJ
aiua-13762	317	31	penetrance	penetrance	NOUN
aiua-13762	317	32	mutation	mutation	NOUN
aiua-13762	317	33	.	.	PUNCT
aiua-13762	318	1	the	the	DET
aiua-13762	318	2	presence	presence	NOUN
aiua-13762	318	3	of	of	ADP
aiua-13762	318	4	a	a	DET
aiua-13762	318	5	combination	combination	NOUN
aiua-13762	318	6	of	of	ADP
aiua-13762	318	7	multiple	multiple	ADJ
aiua-13762	318	8	risk	risk	NOUN
aiua-13762	318	9	alleles	allele	NOUN
aiua-13762	318	10	may	may	AUX
aiua-13762	318	11	thus	thus	ADV
aiua-13762	318	12	increase	increase	VERB
aiua-13762	318	13	the	the	DET
aiua-13762	318	14	likelihood	likelihood	NOUN
aiua-13762	318	15	of	of	ADP
aiua-13762	318	16	developing	develop	VERB
aiua-13762	318	17	prostate	prostate	NOUN
aiua-13762	318	18	cancer	cancer	NOUN
aiua-13762	318	19	more	more	ADJ
aiua-13762	318	20	than	than	ADP
aiua-13762	318	21	any	any	DET
aiua-13762	318	22	individual	individual	ADJ
aiua-13762	318	23	mutation	mutation	NOUN
aiua-13762	318	24	.	.	PUNCT
aiua-13762	319	1	seibert	seibert	PROPN
aiua-13762	319	2	and	and	CCONJ
aiua-13762	319	3	colleagues	colleague	NOUN
aiua-13762	319	4	demonstrated	demonstrate	VERB
aiua-13762	319	5	that	that	SCONJ
aiua-13762	319	6	when	when	SCONJ
aiua-13762	319	7	the	the	DET
aiua-13762	319	8	penetrance	penetrance	NOUN
aiua-13762	319	9	of	of	ADP
aiua-13762	319	10	mutations	mutation	NOUN
aiua-13762	319	11	is	be	AUX
aiua-13762	319	12	plotted	plot	VERB
aiua-13762	319	13	against	against	ADP
aiua-13762	319	14	their	their	PRON
aiua-13762	319	15	frequency	frequency	NOUN
aiua-13762	319	16	in	in	ADP
aiua-13762	319	17	a	a	DET
aiua-13762	319	18	given	give	VERB
aiua-13762	319	19	population	population	NOUN
aiua-13762	319	20	,	,	PUNCT
aiua-13762	319	21	low	low	ADJ
aiua-13762	319	22	-	-	PUNCT
aiua-13762	319	23	penetrance	penetrance	NOUN
aiua-13762	319	24	prostate	prostate	NOUN
aiua-13762	319	25	cancer	cancer	NOUN
aiua-13762	319	26	risk	risk	NOUN
aiua-13762	319	27	variants	variant	NOUN
aiua-13762	319	28	-when	-when	NOUN
aiua-13762	319	29	combined	combine	VERB
aiua-13762	319	30	into	into	ADP
aiua-13762	319	31	polygenic	polygenic	ADJ
aiua-13762	319	32	risk	risk	NOUN
aiua-13762	319	33	scorescan	scorescan	AUX
aiua-13762	319	34	have	have	VERB
aiua-13762	319	35	a	a	DET
aiua-13762	319	36	net	net	ADJ
aiua-13762	319	37	effect	effect	NOUN
aiua-13762	319	38	comparable	comparable	ADJ
aiua-13762	319	39	to	to	ADP
aiua-13762	319	40	that	that	PRON
aiua-13762	319	41	of	of	ADP
aiua-13762	319	42	rare	rare	ADJ
aiua-13762	319	43	pathogenic	pathogenic	ADJ
aiua-13762	319	44	mutations	mutation	NOUN
aiua-13762	319	45	with	with	ADP
aiua-13762	319	46	modest	modest	ADJ
aiua-13762	319	47	-	-	PUNCT
aiua-13762	319	48	to	to	ADP
aiua-13762	319	49	-	-	PUNCT
aiua-13762	319	50	intermediate	intermediate	ADJ
aiua-13762	319	51	penetrance	penetrance	NOUN
aiua-13762	319	52	(	(	PUNCT
aiua-13762	319	53	110	110	NUM
aiua-13762	319	54	)	)	PUNCT
aiua-13762	319	55	.	.	PUNCT
aiua-13762	320	1	moreover	moreover	ADV
aiua-13762	320	2	,	,	PUNCT
aiua-13762	320	3	many	many	ADJ
aiua-13762	320	4	linkage	linkage	NOUN
aiua-13762	320	5	analyses	analysis	NOUN
aiua-13762	320	6	in	in	ADP
aiua-13762	320	7	studies	study	NOUN
aiua-13762	320	8	examining	examine	VERB
aiua-13762	320	9	prostate	prostate	NOUN
aiua-13762	320	10	cancer	cancer	NOUN
aiua-13762	320	11	among	among	ADP
aiua-13762	320	12	aj	aj	PROPN
aiua-13762	320	13	are	be	AUX
aiua-13762	320	14	limited	limit	VERB
aiua-13762	320	15	by	by	ADP
aiua-13762	320	16	small	small	ADJ
aiua-13762	320	17	sample	sample	NOUN
aiua-13762	320	18	sizes	size	NOUN
aiua-13762	320	19	and	and	CCONJ
aiua-13762	320	20	lack	lack	NOUN
aiua-13762	320	21	of	of	ADP
aiua-13762	320	22	cohort	cohort	NOUN
aiua-13762	320	23	diversity	diversity	NOUN
aiua-13762	320	24	.	.	PUNCT
aiua-13762	321	1	simard	simard	PROPN
aiua-13762	321	2	and	and	CCONJ
aiua-13762	321	3	colleagues	colleague	NOUN
aiua-13762	321	4	suggested	suggest	VERB
aiua-13762	321	5	that	that	SCONJ
aiua-13762	321	6	association	association	NOUN
aiua-13762	321	7	studies	study	NOUN
aiua-13762	321	8	should	should	AUX
aiua-13762	321	9	ideally	ideally	ADV
aiua-13762	321	10	be	be	AUX
aiua-13762	321	11	based	base	VERB
aiua-13762	321	12	on	on	ADP
aiua-13762	321	13	at	at	ADV
aiua-13762	321	14	least	least	ADV
aiua-13762	321	15	one	one	NUM
aiua-13762	321	16	thousand	thousand	NUM
aiua-13762	321	17	blood	blood	NOUN
aiua-13762	321	18	samples	sample	NOUN
aiua-13762	321	19	from	from	ADP
aiua-13762	321	20	prostate	prostate	NOUN
aiua-13762	321	21	cancer	cancer	NOUN
aiua-13762	321	22	cases	case	NOUN
aiua-13762	321	23	,	,	PUNCT
aiua-13762	321	24	compared	compare	VERB
aiua-13762	321	25	to	to	ADP
aiua-13762	321	26	ethnically	ethnically	ADV
aiua-13762	321	27	matched	match	VERB
aiua-13762	321	28	controls	control	NOUN
aiua-13762	321	29	(	(	PUNCT
aiua-13762	321	30	24	24	NUM
aiua-13762	321	31	)	)	PUNCT
aiua-13762	321	32	.	.	PUNCT
aiua-13762	322	1	therefore	therefore	ADV
aiua-13762	322	2	,	,	PUNCT
aiua-13762	322	3	adequately	adequately	ADV
aiua-13762	322	4	powered	power	VERB
aiua-13762	322	5	studies	study	NOUN
aiua-13762	322	6	are	be	AUX
aiua-13762	322	7	necessary	necessary	ADJ
aiua-13762	322	8	to	to	PART
aiua-13762	322	9	provide	provide	VERB
aiua-13762	322	10	more	more	ADJ
aiua-13762	322	11	definitive	definitive	ADJ
aiua-13762	322	12	insights	insight	NOUN
aiua-13762	322	13	into	into	ADP
aiua-13762	322	14	prostate	prostate	NOUN
aiua-13762	322	15	cancer	cancer	NOUN
aiua-13762	322	16	susceptibility	susceptibility	NOUN
aiua-13762	322	17	conferred	confer	VERB
aiua-13762	322	18	by	by	ADP
aiua-13762	322	19	low	low	ADJ
aiua-13762	322	20	-	-	PUNCT
aiua-13762	322	21	penetrance	penetrance	NOUN
aiua-13762	322	22	genes	gene	NOUN
aiua-13762	322	23	.	.	PUNCT
aiua-13762	323	1	references	reference	NOUN
aiua-13762	323	2	1	1	NUM
aiua-13762	323	3	.	.	PUNCT
aiua-13762	323	4	https://www.gov.il/blobfolder/reports/prostate2022/en/files_publications_units_icdc_prostate20	https://www.gov.il/blobfolder/reports/prostate2022/en/files_publications_units_icdc_prostate20	PROPN
aiua-13762	323	5	22.pdf	22.pdf	PROPN
aiua-13762	323	6	.	.	PUNCT
aiua-13762	324	1	2	2	NUM
aiua-13762	324	2	.	.	X
aiua-13762	324	3	alanee	alanee	PROPN
aiua-13762	324	4	s	s	PROPN
aiua-13762	324	5	,	,	PUNCT
aiua-13762	324	6	shah	shah	PROPN
aiua-13762	324	7	s	s	PROPN
aiua-13762	324	8	,	,	PUNCT
aiua-13762	324	9	vijai	vijai	PROPN
aiua-13762	324	10	j	j	PROPN
aiua-13762	324	11	,	,	PUNCT
aiua-13762	324	12	schrader	schrader	PROPN
aiua-13762	324	13	k	k	PROPN
aiua-13762	324	14	,	,	PUNCT
aiua-13762	324	15	et	et	PROPN
aiua-13762	324	16	al	al	PROPN
aiua-13762	324	17	.	.	PUNCT
aiua-13762	325	1	prevalence	prevalence	NOUN
aiua-13762	325	2	of	of	ADP
aiua-13762	325	3	hoxb13	hoxb13	PROPN
aiua-13762	325	4	mutation	mutation	NOUN
aiua-13762	325	5	in	in	ADP
aiua-13762	325	6	a	a	DET
aiua-13762	325	7	population	population	NOUN
aiua-13762	325	8	of	of	ADP
aiua-13762	325	9	ashkenazi	ashkenazi	ADJ
aiua-13762	325	10	jewish	jewish	ADJ
aiua-13762	325	11	men	man	NOUN
aiua-13762	325	12	treated	treat	VERB
aiua-13762	325	13	for	for	ADP
aiua-13762	325	14	prostate	prostate	NOUN
aiua-13762	325	15	cancer	cancer	NOUN
aiua-13762	325	16	.	.	PUNCT
aiua-13762	326	1	fam	fam	NOUN
aiua-13762	326	2	cancer	cancer	NOUN
aiua-13762	326	3	2013	2013	NUM
aiua-13762	326	4	;	;	PUNCT
aiua-13762	326	5	12:597	12:597	NUM
aiua-13762	326	6	-	-	SYM
aiua-13762	326	7	600	600	NUM
aiua-13762	326	8	.	.	PUNCT
aiua-13762	327	1	3	3	X
aiua-13762	327	2	.	.	X
aiua-13762	327	3	carter	carter	PROPN
aiua-13762	327	4	bs	bs	PROPN
aiua-13762	327	5	,	,	PUNCT
aiua-13762	327	6	beaty	beaty	PROPN
aiua-13762	327	7	th	th	PROPN
aiua-13762	327	8	,	,	PUNCT
aiua-13762	327	9	steinberg	steinberg	PROPN
aiua-13762	327	10	gd	gd	PROPN
aiua-13762	327	11	,	,	PUNCT
aiua-13762	327	12	et	et	PROPN
aiua-13762	327	13	al	al	PROPN
aiua-13762	327	14	.	.	PUNCT
aiua-13762	327	15	mendelian	mendelian	ADJ
aiua-13762	327	16	inheritance	inheritance	NOUN
aiua-13762	327	17	of	of	ADP
aiua-13762	327	18	familial	familial	ADJ
aiua-13762	327	19	prostate	prostate	NOUN
aiua-13762	327	20	cancer	cancer	NOUN
aiua-13762	327	21	.	.	PUNCT
aiua-13762	328	1	proc	proc	PROPN
aiua-13762	328	2	natl	natl	PROPN
aiua-13762	328	3	acad	acad	PROPN
aiua-13762	328	4	sci	sci	PROPN
aiua-13762	328	5	u	u	PROPN
aiua-13762	328	6	s	s	PROPN
aiua-13762	328	7	a	a	DET
aiua-13762	328	8	1992	1992	NUM
aiua-13762	328	9	;	;	PUNCT
aiua-13762	328	10	89:3367	89:3367	NUM
aiua-13762	328	11	-	-	SYM
aiua-13762	328	12	71	71	NUM
aiua-13762	328	13	.	.	NOUN
aiua-13762	329	1	4	4	NUM
aiua-13762	329	2	.	.	X
aiua-13762	329	3	steinberg	steinberg	PROPN
aiua-13762	329	4	gd	gd	PROPN
aiua-13762	329	5	,	,	PUNCT
aiua-13762	329	6	carter	carter	PROPN
aiua-13762	329	7	bs	bs	PROPN
aiua-13762	329	8	,	,	PUNCT
aiua-13762	329	9	beaty	beaty	PROPN
aiua-13762	329	10	th	th	PROPN
aiua-13762	329	11	,	,	PUNCT
aiua-13762	329	12	et	et	PROPN
aiua-13762	329	13	al	al	PROPN
aiua-13762	329	14	.	.	PUNCT
aiua-13762	329	15	family	family	NOUN
aiua-13762	329	16	history	history	NOUN
aiua-13762	329	17	and	and	CCONJ
aiua-13762	329	18	the	the	DET
aiua-13762	329	19	risk	risk	NOUN
aiua-13762	329	20	of	of	ADP
aiua-13762	329	21	prostate	prostate	NOUN
aiua-13762	329	22	cancer	cancer	NOUN
aiua-13762	329	23	.	.	PUNCT
aiua-13762	330	1	prostate	prostate	NOUN
aiua-13762	330	2	1990	1990	NUM
aiua-13762	330	3	;	;	PUNCT
aiua-13762	330	4	17:337	17:337	NUM
aiua-13762	330	5	-	-	SYM
aiua-13762	330	6	47	47	NUM
aiua-13762	330	7	.	.	PUNCT
aiua-13762	331	1	5	5	X
aiua-13762	331	2	.	.	PUNCT
aiua-13762	332	1	lichtenstein	lichtenstein	PROPN
aiua-13762	332	2	p	p	PROPN
aiua-13762	332	3	,	,	PUNCT
aiua-13762	332	4	holm	holm	PROPN
aiua-13762	332	5	nv	nv	PROPN
aiua-13762	332	6	,	,	PUNCT
aiua-13762	332	7	verkasalo	verkasalo	PROPN
aiua-13762	332	8	pk	pk	PROPN
aiua-13762	332	9	,	,	PUNCT
aiua-13762	332	10	et	et	PROPN
aiua-13762	332	11	al	al	PROPN
aiua-13762	332	12	.	.	PROPN
aiua-13762	333	1	environmental	environmental	ADJ
aiua-13762	333	2	and	and	CCONJ
aiua-13762	333	3	heritable	heritable	ADJ
aiua-13762	333	4	factors	factor	NOUN
aiua-13762	333	5	in	in	ADP
aiua-13762	333	6	the	the	DET
aiua-13762	333	7	causation	causation	NOUN
aiua-13762	333	8	of	of	ADP
aiua-13762	333	9	cancer	cancer	NOUN
aiua-13762	333	10	--	--	PUNCT
aiua-13762	333	11	analyses	analysis	NOUN
aiua-13762	333	12	of	of	ADP
aiua-13762	333	13	cohorts	cohort	NOUN
aiua-13762	333	14	of	of	ADP
aiua-13762	333	15	twins	twin	NOUN
aiua-13762	333	16	from	from	ADP
aiua-13762	333	17	sweden	sweden	PROPN
aiua-13762	333	18	,	,	PUNCT
aiua-13762	333	19	denmark	denmark	NOUN
aiua-13762	333	20	,	,	PUNCT
aiua-13762	333	21	and	and	CCONJ
aiua-13762	333	22	finland	finland	PROPN
aiua-13762	333	23	.	.	PUNCT
aiua-13762	334	1	n	n	PROPN
aiua-13762	334	2	engl	engl	PROPN
aiua-13762	334	3	j	j	PROPN
aiua-13762	334	4	med	med	PROPN
aiua-13762	334	5	2000	2000	NUM
aiua-13762	334	6	;	;	PUNCT
aiua-13762	334	7	343:78	343:78	PROPN
aiua-13762	334	8	-	-	PUNCT
aiua-13762	334	9	85	85	NUM
aiua-13762	334	10	.	.	NOUN
aiua-13762	334	11	6	6	NUM
aiua-13762	334	12	.	.	X
aiua-13762	334	13	bruner	bruner	PROPN
aiua-13762	334	14	dw	dw	PROPN
aiua-13762	334	15	,	,	PUNCT
aiua-13762	334	16	moore	moore	PROPN
aiua-13762	334	17	d	d	PROPN
aiua-13762	334	18	,	,	PUNCT
aiua-13762	334	19	parlanti	parlanti	ADV
aiua-13762	334	20	a	a	X
aiua-13762	334	21	,	,	PUNCT
aiua-13762	334	22	et	et	PROPN
aiua-13762	334	23	al	al	PROPN
aiua-13762	334	24	.	.	PROPN
aiua-13762	334	25	relative	relative	ADJ
aiua-13762	334	26	risk	risk	NOUN
aiua-13762	334	27	of	of	ADP
aiua-13762	334	28	prostate	prostate	NOUN
aiua-13762	334	29	cancer	cancer	NOUN
aiua-13762	334	30	for	for	ADP
aiua-13762	334	31	men	man	NOUN
aiua-13762	334	32	with	with	ADP
aiua-13762	334	33	affected	affected	ADJ
aiua-13762	334	34	relatives	relative	NOUN
aiua-13762	334	35	:	:	PUNCT
aiua-13762	334	36	systematic	systematic	ADJ
aiua-13762	334	37	review	review	NOUN
aiua-13762	334	38	and	and	CCONJ
aiua-13762	334	39	metaanalysis	metaanalysis	NOUN
aiua-13762	334	40	.	.	PUNCT
aiua-13762	335	1	int	int	NOUN
aiua-13762	335	2	j	j	PROPN
aiua-13762	335	3	cancer	cancer	NOUN
aiua-13762	335	4	2003	2003	NUM
aiua-13762	335	5	;	;	PUNCT
aiua-13762	335	6	107:797	107:797	NUM
aiua-13762	335	7	-	-	SYM
aiua-13762	335	8	803	803	NUM
aiua-13762	335	9	.	.	PUNCT
aiua-13762	336	1	7	7	X
aiua-13762	336	2	.	.	X
aiua-13762	336	3	zeegers	zeegers	PROPN
aiua-13762	336	4	mp	mp	PROPN
aiua-13762	336	5	,	,	PUNCT
aiua-13762	336	6	jellema	jellema	X
aiua-13762	336	7	a	a	PRON
aiua-13762	336	8	,	,	PUNCT
aiua-13762	336	9	ostrer	ostrer	PROPN
aiua-13762	336	10	h.	h.	PROPN
aiua-13762	336	11	empiric	empiric	ADJ
aiua-13762	336	12	risk	risk	NOUN
aiua-13762	336	13	of	of	ADP
aiua-13762	336	14	prostate	prostate	NOUN
aiua-13762	336	15	carcinoma	carcinoma	NOUN
aiua-13762	336	16	for	for	ADP
aiua-13762	336	17	relatives	relative	NOUN
aiua-13762	336	18	of	of	ADP
aiua-13762	336	19	patients	patient	NOUN
aiua-13762	336	20	with	with	ADP
aiua-13762	336	21	prostate	prostate	NOUN
aiua-13762	336	22	carcinoma	carcinoma	NOUN
aiua-13762	336	23	:	:	PUNCT
aiua-13762	336	24	a	a	DET
aiua-13762	336	25	meta	meta	ADJ
aiua-13762	336	26	-	-	PUNCT
aiua-13762	336	27	analysis	analysis	NOUN
aiua-13762	336	28	.	.	PUNCT
aiua-13762	337	1	cancer	cancer	NOUN
aiua-13762	337	2	2003	2003	NUM
aiua-13762	337	3	;	;	PUNCT
aiua-13762	337	4	97:1894	97:1894	X
aiua-13762	337	5	-	-	SYM
aiua-13762	337	6	903	903	NUM
aiua-13762	337	7	.	.	PUNCT
aiua-13762	337	8	8	8	NUM
aiua-13762	337	9	.	.	X
aiua-13762	338	1	zheng	zheng	PROPN
aiua-13762	338	2	q	q	X
aiua-13762	338	3	,	,	PUNCT
aiua-13762	338	4	ying	ying	PROPN
aiua-13762	338	5	q	q	PROPN
aiua-13762	338	6	,	,	PUNCT
aiua-13762	338	7	ren	ren	PROPN
aiua-13762	338	8	z	z	PROPN
aiua-13762	338	9	,	,	PUNCT
aiua-13762	338	10	et	et	PROPN
aiua-13762	338	11	al	al	PROPN
aiua-13762	338	12	.	.	PUNCT
aiua-13762	338	13	first	first	ADJ
aiua-13762	338	14	-	-	PUNCT
aiua-13762	338	15	degree	degree	NOUN
aiua-13762	338	16	family	family	NOUN
aiua-13762	338	17	history	history	NOUN
aiua-13762	338	18	of	of	ADP
aiua-13762	338	19	prostate	prostate	NOUN
aiua-13762	338	20	cancer	cancer	NOUN
aiua-13762	338	21	is	be	AUX
aiua-13762	338	22	associated	associate	VERB
aiua-13762	338	23	with	with	ADP
aiua-13762	338	24	the	the	DET
aiua-13762	338	25	risk	risk	NOUN
aiua-13762	338	26	of	of	ADP
aiua-13762	338	27	breast	breast	NOUN
aiua-13762	338	28	cancer	cancer	NOUN
aiua-13762	338	29	and	and	CCONJ
aiua-13762	338	30	ovarian	ovarian	ADJ
aiua-13762	338	31	cancer	cancer	NOUN
aiua-13762	338	32	.	.	PUNCT
aiua-13762	339	1	medicine	medicine	NOUN
aiua-13762	339	2	(	(	PUNCT
aiua-13762	339	3	baltimore	baltimore	PROPN
aiua-13762	339	4	.	.	PROPN
aiua-13762	339	5	2021	2021	NUM
aiua-13762	339	6	;	;	PUNCT
aiua-13762	339	7	100	100	NUM
aiua-13762	339	8	:	:	PUNCT
aiua-13762	339	9	e23816	e23816	PROPN
aiua-13762	339	10	.	.	PUNCT
aiua-13762	340	1	9	9	NUM
aiua-13762	340	2	.	.	NOUN
aiua-13762	340	3	tryggvadóttir	tryggvadóttir	PROPN
aiua-13762	340	4	l	l	PROPN
aiua-13762	340	5	,	,	PUNCT
aiua-13762	340	6	vidarsdóttir	vidarsdóttir	ADJ
aiua-13762	340	7	l	l	NOUN
aiua-13762	340	8	,	,	PUNCT
aiua-13762	340	9	thorgeirsson	thorgeirsson	NOUN
aiua-13762	340	10	t	t	PROPN
aiua-13762	340	11	,	,	PUNCT
aiua-13762	340	12	et	et	PROPN
aiua-13762	340	13	al	al	PROPN
aiua-13762	340	14	.	.	PROPN
aiua-13762	340	15	prostate	prostate	NOUN
aiua-13762	340	16	cancer	cancer	NOUN
aiua-13762	340	17	progression	progression	NOUN
aiua-13762	340	18	and	and	CCONJ
aiua-13762	340	19	survival	survival	NOUN
aiua-13762	340	20	in	in	ADP
aiua-13762	340	21	brca2	brca2	NOUN
aiua-13762	340	22	mutation	mutation	NOUN
aiua-13762	340	23	carriers	carrier	NOUN
aiua-13762	340	24	.	.	PUNCT
aiua-13762	341	1	j	j	PROPN
aiua-13762	341	2	natl	natl	PROPN
aiua-13762	341	3	cancer	cancer	PROPN
aiua-13762	341	4	inst	inst	PROPN
aiua-13762	341	5	.	.	PUNCT
aiua-13762	341	6	2007	2007	NUM
aiua-13762	341	7	;	;	PUNCT
aiua-13762	341	8	99:929	99:929	NUM
aiua-13762	341	9	-	-	SYM
aiua-13762	341	10	35	35	NUM
aiua-13762	341	11	.	.	PUNCT
aiua-13762	342	1	10	10	NUM
aiua-13762	342	2	.	.	PUNCT
aiua-13762	343	1	xue	xue	PROPN
aiua-13762	343	2	j	j	PROPN
aiua-13762	343	3	,	,	PUNCT
aiua-13762	343	4	lencz	lencz	PROPN
aiua-13762	343	5	t	t	PROPN
aiua-13762	343	6	,	,	PUNCT
aiua-13762	343	7	darvasi	darvasi	PROPN
aiua-13762	343	8	a	a	X
aiua-13762	343	9	,	,	PUNCT
aiua-13762	343	10	et	et	PROPN
aiua-13762	343	11	al	al	PROPN
aiua-13762	343	12	.	.	PUNCT
aiua-13762	344	1	the	the	DET
aiua-13762	344	2	time	time	NOUN
aiua-13762	344	3	and	and	CCONJ
aiua-13762	344	4	place	place	NOUN
aiua-13762	344	5	of	of	ADP
aiua-13762	344	6	european	european	ADJ
aiua-13762	344	7	admixture	admixture	NOUN
aiua-13762	344	8	in	in	ADP
aiua-13762	344	9	ashkenazi	ashkenazi	ADJ
aiua-13762	344	10	jewish	jewish	ADJ
aiua-13762	344	11	history	history	NOUN
aiua-13762	344	12	.	.	PUNCT
aiua-13762	345	1	plos	plos	PROPN
aiua-13762	345	2	genetics	genetics	PROPN
aiua-13762	345	3	2017	2017	NUM
aiua-13762	345	4	;	;	PUNCT
aiua-13762	345	5	13	13	NUM
aiua-13762	345	6	:	:	SYM
aiua-13762	345	7	e1006644	e1006644	ADJ
aiua-13762	345	8	.	.	PUNCT
aiua-13762	345	9	11	11	NUM
aiua-13762	345	10	.	.	PUNCT
aiua-13762	346	1	waldman	waldman	PROPN
aiua-13762	346	2	s	s	PROPN
aiua-13762	346	3	,	,	PUNCT
aiua-13762	346	4	backenroth	backenroth	PROPN
aiua-13762	346	5	d	d	PROPN
aiua-13762	346	6	,	,	PUNCT
aiua-13762	346	7	harney	harney	NOUN
aiua-13762	346	8	e	e	NOUN
aiua-13762	346	9	,	,	PUNCT
aiua-13762	346	10	et	et	PROPN
aiua-13762	346	11	al	al	PROPN
aiua-13762	346	12	.	.	PUNCT
aiua-13762	346	13	genome	genome	NOUN
aiua-13762	346	14	-	-	PUNCT
aiua-13762	346	15	wide	wide	ADJ
aiua-13762	346	16	data	datum	NOUN
aiua-13762	346	17	from	from	ADP
aiua-13762	346	18	medieval	medieval	ADJ
aiua-13762	346	19	german	german	ADJ
aiua-13762	346	20	jews	jews	PROPN
aiua-13762	346	21	show	show	VERB
aiua-13762	346	22	that	that	SCONJ
aiua-13762	346	23	the	the	DET
aiua-13762	346	24	ashkenazi	ashkenazi	ADJ
aiua-13762	346	25	founder	founder	NOUN
aiua-13762	346	26	event	event	NOUN
aiua-13762	346	27	pre	pre	VERB
aiua-13762	346	28	-	-	VERB
aiua-13762	346	29	dated	date	VERB
aiua-13762	346	30	the	the	DET
aiua-13762	346	31	14th	14th	ADJ
aiua-13762	346	32	century	century	NOUN
aiua-13762	346	33	.	.	PUNCT
aiua-13762	347	1	cell	cell	NOUN
aiua-13762	347	2	2022	2022	NUM
aiua-13762	347	3	;	;	PUNCT
aiua-13762	347	4	185:4703	185:4703	NUM
aiua-13762	347	5	-	-	SYM
aiua-13762	347	6	16	16	NUM
aiua-13762	347	7	.	.	PUNCT
aiua-13762	347	8	12	12	NUM
aiua-13762	347	9	.	.	PUNCT
aiua-13762	348	1	dellapergola	dellapergola	PROPN
aiua-13762	348	2	s.	s.	PROPN
aiua-13762	348	3	notes	note	VERB
aiua-13762	348	4	toward	toward	ADP
aiua-13762	348	5	a	a	DET
aiua-13762	348	6	demographic	demographic	ADJ
aiua-13762	348	7	history	history	NOUN
aiua-13762	348	8	of	of	ADP
aiua-13762	348	9	the	the	DET
aiua-13762	348	10	jews	jews	PROPN
aiua-13762	348	11	.	.	PUNCT
aiua-13762	349	1	genealogy	genealogy	NOUN
aiua-13762	349	2	2024	2024	NUM
aiua-13762	349	3	;	;	PUNCT
aiua-13762	349	4	8,1	8,1	NOUN
aiua-13762	349	5	-	-	SYM
aiua-13762	349	6	29	29	NUM
aiua-13762	349	7	13	13	NUM
aiua-13762	349	8	.	.	PUNCT
aiua-13762	350	1	stampfer	stampfer	PROPN
aiua-13762	350	2	s.	s.	PROPN
aiua-13762	350	3	settling	settle	VERB
aiua-13762	350	4	down	down	ADP
aiua-13762	350	5	in	in	ADP
aiua-13762	350	6	eastern	eastern	PROPN
aiua-13762	350	7	europe	europe	PROPN
aiua-13762	350	8	.	.	PUNCT
aiua-13762	351	1	in	in	ADP
aiua-13762	351	2	:	:	PUNCT
aiua-13762	351	3	grill	grill	PROPN
aiua-13762	351	4	t	t	PROPN
aiua-13762	351	5	,	,	PUNCT
aiua-13762	351	6	ed	ed	NOUN
aiua-13762	351	7	.	.	PUNCT
aiua-13762	352	1	jews	jews	PROPN
aiua-13762	352	2	and	and	CCONJ
aiua-13762	352	3	germans	germans	PROPN
aiua-13762	352	4	in	in	ADP
aiua-13762	352	5	eastern	eastern	PROPN
aiua-13762	352	6	europe	europe	PROPN
aiua-13762	352	7	.	.	PUNCT
aiua-13762	353	1	shared	share	VERB
aiua-13762	353	2	and	and	CCONJ
aiua-13762	353	3	comparative	comparative	ADJ
aiua-13762	353	4	histories	history	NOUN
aiua-13762	353	5	.	.	PUNCT
aiua-13762	354	1	berlin	berlin	PROPN
aiua-13762	354	2	:	:	PUNCT
aiua-13762	354	3	de	de	X
aiua-13762	354	4	gruyter	gruyter	NOUN
aiua-13762	354	5	2018	2018	NUM
aiua-13762	354	6	.	.	PUNCT
aiua-13762	355	1	pp	pp	ADJ
aiua-13762	355	2	.	.	PUNCT
aiua-13762	356	1	1	1	NUM
aiua-13762	356	2	-	-	SYM
aiua-13762	356	3	20	20	NUM
aiua-13762	356	4	.	.	PUNCT
aiua-13762	357	1	14	14	NUM
aiua-13762	357	2	.	.	PUNCT
aiua-13762	358	1	toch	toch	PROPN
aiua-13762	358	2	m.	m.	PROPN
aiua-13762	358	3	the	the	DET
aiua-13762	358	4	emergence	emergence	NOUN
aiua-13762	358	5	of	of	ADP
aiua-13762	358	6	the	the	DET
aiua-13762	358	7	medieval	medieval	ADJ
aiua-13762	358	8	jewish	jewish	ADJ
aiua-13762	358	9	diaspora(s	diaspora(s	PROPN
aiua-13762	358	10	)	)	PUNCT
aiua-13762	358	11	of	of	ADP
aiua-13762	358	12	europe	europe	PROPN
aiua-13762	358	13	from	from	ADP
aiua-13762	358	14	the	the	DET
aiua-13762	358	15	ninth	ninth	ADJ
aiua-13762	358	16	to	to	ADP
aiua-13762	358	17	the	the	DET
aiua-13762	358	18	twelfth	twelfth	ADJ
aiua-13762	358	19	centuries	century	NOUN
aiua-13762	358	20	,	,	PUNCT
aiua-13762	358	21	with	with	ADP
aiua-13762	358	22	some	some	DET
aiua-13762	358	23	thoughts	thought	NOUN
aiua-13762	358	24	on	on	ADP
aiua-13762	358	25	historical	historical	ADJ
aiua-13762	358	26	dna	dna	PROPN
aiua-13762	358	27	studies	study	NOUN
aiua-13762	358	28	.	.	PUNCT
aiua-13762	359	1	in	in	ADP
aiua-13762	359	2	:	:	PUNCT
aiua-13762	359	3	castaño	castaño	PROPN
aiua-13762	359	4	j	j	PROPN
aiua-13762	359	5	,	,	PUNCT
aiua-13762	359	6	fishman	fishman	PROPN
aiua-13762	359	7	t	t	PROPN
aiua-13762	359	8	,	,	PUNCT
aiua-13762	359	9	kanarfogel	kanarfogel	NOUN
aiua-13762	359	10	e	e	PROPN
aiua-13762	359	11	,	,	PUNCT
aiua-13762	359	12	eds	ed	NOUN
aiua-13762	359	13	.	.	PUNCT
aiua-13762	359	14	regional	regional	ADJ
aiua-13762	359	15	identities	identity	NOUN
aiua-13762	359	16	and	and	CCONJ
aiua-13762	359	17	cultures	culture	NOUN
aiua-13762	359	18	of	of	ADP
aiua-13762	359	19	medieval	medieval	ADJ
aiua-13762	359	20	jews	jews	PROPN
aiua-13762	359	21	.	.	PUNCT
aiua-13762	360	1	london	london	PROPN
aiua-13762	360	2	:	:	PUNCT
aiua-13762	360	3	the	the	DET
aiua-13762	360	4	littman	littman	PROPN
aiua-13762	360	5	library	library	PROPN
aiua-13762	360	6	2018	2018	NUM
aiua-13762	360	7	.	.	PUNCT
aiua-13762	361	1	pp	pp	ADV
aiua-13762	361	2	21	21	NUM
aiua-13762	361	3	-	-	SYM
aiua-13762	361	4	35	35	NUM
aiua-13762	361	5	.	.	PUNCT
aiua-13762	362	1	15	15	NUM
aiua-13762	362	2	.	.	PUNCT
aiua-13762	363	1	dellapergola	dellapergola	PROPN
aiua-13762	363	2	s.	s.	PROPN
aiua-13762	363	3	world	world	PROPN
aiua-13762	363	4	jewish	jewish	ADJ
aiua-13762	363	5	population	population	NOUN
aiua-13762	363	6	2023	2023	NUM
aiua-13762	363	7	.	.	PUNCT
aiua-13762	364	1	in	in	ADP
aiua-13762	364	2	:	:	PUNCT
aiua-13762	364	3	dashefsky	dashefsky	VERB
aiua-13762	364	4	a	a	PRON
aiua-13762	364	5	,	,	PUNCT
aiua-13762	364	6	sheskin	sheskin	ADJ
aiua-13762	364	7	i	i	PROPN
aiua-13762	364	8	,	,	PUNCT
aiua-13762	364	9	eds	eds	PROPN
aiua-13762	364	10	.	.	PUNCT
aiua-13762	364	11	american	american	ADJ
aiua-13762	364	12	jewish	jewish	ADJ
aiua-13762	364	13	year	year	NOUN
aiua-13762	364	14	book	book	NOUN
aiua-13762	364	15	2023	2023	NUM
aiua-13762	364	16	.	.	PUNCT
aiua-13762	365	1	cham	cham	PROPN
aiua-13762	365	2	:	:	PUNCT
aiua-13762	365	3	springer	springer	NOUN
aiua-13762	365	4	2024	2024	NUM
aiua-13762	365	5	.	.	PUNCT
aiua-13762	366	1	pp	pp	ADJ
aiua-13762	366	2	.	.	PUNCT
aiua-13762	367	1	309	309	NUM
aiua-13762	367	2	-	-	SYM
aiua-13762	367	3	422	422	NUM
aiua-13762	367	4	.	.	PUNCT
aiua-13762	368	1	16	16	NUM
aiua-13762	368	2	.	.	PUNCT
aiua-13762	369	1	charrow	charrow	PROPN
aiua-13762	369	2	j.	j.	PROPN
aiua-13762	369	3	ashkenazi	ashkenazi	PROPN
aiua-13762	369	4	jewish	jewish	ADJ
aiua-13762	369	5	genetic	genetic	ADJ
aiua-13762	369	6	disorders	disorder	NOUN
aiua-13762	369	7	.	.	PUNCT
aiua-13762	370	1	fam	fam	NOUN
aiua-13762	370	2	cancer	cancer	NOUN
aiua-13762	370	3	.	.	PUNCT
aiua-13762	371	1	2004	2004	NUM
aiua-13762	371	2	;	;	PUNCT
aiua-13762	371	3	3:201	3:201	NUM
aiua-13762	371	4	-	-	SYM
aiua-13762	371	5	6	6	NUM
aiua-13762	371	6	.	.	NOUN
aiua-13762	371	7	17	17	NUM
aiua-13762	371	8	.	.	PUNCT
aiua-13762	372	1	risch	risch	PROPN
aiua-13762	372	2	n	n	SYM
aiua-13762	372	3	,	,	PUNCT
aiua-13762	372	4	tang	tang	PROPN
aiua-13762	372	5	h	h	PROPN
aiua-13762	372	6	,	,	PUNCT
aiua-13762	372	7	katzenstein	katzenstein	PROPN
aiua-13762	372	8	h	h	NOUN
aiua-13762	372	9	,	,	PUNCT
aiua-13762	372	10	and	and	CCONJ
aiua-13762	372	11	ekstein	ekstein	ADJ
aiua-13762	372	12	j.	j.	PROPN
aiua-13762	372	13	geographic	geographic	ADJ
aiua-13762	372	14	distribution	distribution	NOUN
aiua-13762	372	15	of	of	ADP
aiua-13762	372	16	disease	disease	NOUN
aiua-13762	372	17	mutations	mutation	NOUN
aiua-13762	372	18	in	in	ADP
aiua-13762	372	19	the	the	DET
aiua-13762	372	20	ashkenazi	ashkenazi	ADJ
aiua-13762	372	21	jewish	jewish	ADJ
aiua-13762	372	22	population	population	NOUN
aiua-13762	372	23	supports	support	VERB
aiua-13762	372	24	genetic	genetic	ADJ
aiua-13762	372	25	drift	drift	NOUN
aiua-13762	372	26	over	over	ADP
aiua-13762	372	27	selection	selection	NOUN
aiua-13762	372	28	.	.	PUNCT
aiua-13762	373	1	am	be	AUX
aiua-13762	373	2	j	j	PROPN
aiua-13762	373	3	hum	hum	PROPN
aiua-13762	373	4	genet	genet	PROPN
aiua-13762	373	5	2003,72:812	2003,72:812	PROPN
aiua-13762	373	6	-	-	PUNCT
aiua-13762	373	7	22	22	NUM
aiua-13762	373	8	.	.	PUNCT
aiua-13762	374	1	18	18	NUM
aiua-13762	374	2	.	.	PUNCT
aiua-13762	375	1	lynch	lynch	PROPN
aiua-13762	375	2	ht	ht	PROPN
aiua-13762	375	3	,	,	PUNCT
aiua-13762	375	4	rubinstein	rubinstein	PROPN
aiua-13762	375	5	ws	ws	PROPN
aiua-13762	375	6	,	,	PUNCT
aiua-13762	375	7	locker	locker	PROPN
aiua-13762	375	8	gy	gy	PROPN
aiua-13762	375	9	.	.	PROPN
aiua-13762	375	10	cancer	cancer	NOUN
aiua-13762	375	11	in	in	ADP
aiua-13762	375	12	jews	jews	PROPN
aiua-13762	375	13	:	:	PUNCT
aiua-13762	375	14	introduction	introduction	NOUN
aiua-13762	375	15	and	and	CCONJ
aiua-13762	375	16	overview	overview	NOUN
aiua-13762	375	17	.	.	PUNCT
aiua-13762	376	1	fam	fam	NOUN
aiua-13762	376	2	cancer	cancer	PROPN
aiua-13762	376	3	2004	2004	NUM
aiua-13762	376	4	;	;	PUNCT
aiua-13762	376	5	3:177	3:177	NUM
aiua-13762	376	6	-	-	SYM
aiua-13762	376	7	92	92	NUM
aiua-13762	376	8	.	.	PUNCT
aiua-13762	376	9	19	19	NUM
aiua-13762	376	10	.	.	PUNCT
aiua-13762	377	1	lynch	lynch	PROPN
aiua-13762	377	2	ht	ht	PROPN
aiua-13762	377	3	,	,	PUNCT
aiua-13762	377	4	deters	deter	NOUN
aiua-13762	377	5	ca	ca	PROPN
aiua-13762	377	6	,	,	PUNCT
aiua-13762	377	7	lynch	lynch	PROPN
aiua-13762	377	8	jf	jf	PROPN
aiua-13762	377	9	,	,	PUNCT
aiua-13762	377	10	brand	brand	PROPN
aiua-13762	377	11	re	re	NOUN
aiua-13762	377	12	.	.	PUNCT
aiua-13762	378	1	familial	familial	ADJ
aiua-13762	378	2	pancreatic	pancreatic	ADJ
aiua-13762	378	3	carcinoma	carcinoma	NOUN
aiua-13762	378	4	in	in	ADP
aiua-13762	378	5	jews	jews	PROPN
aiua-13762	378	6	.	.	PUNCT
aiua-13762	379	1	fam	fam	PROPN
aiua-13762	379	2	cancer	cancer	PROPN
aiua-13762	379	3	2004	2004	NUM
aiua-13762	379	4	;	;	PUNCT
aiua-13762	379	5	3:233	3:233	NUM
aiua-13762	379	6	-	-	SYM
aiua-13762	379	7	40	40	NUM
aiua-13762	379	8	.	.	PUNCT
aiua-13762	379	9	20	20	NUM
aiua-13762	379	10	.	.	PUNCT
aiua-13762	380	1	https://www.cancer.gov/publications/pdq/information-summaries/	https://www.cancer.gov/publications/pdq/information-summaries/	NOUN
aiua-13762	380	2	genetics	genetics	PROPN
aiua-13762	380	3	/	/	SYM
aiua-13762	380	4	brca	brca	PROPN
aiua-13762	380	5	-	-	PUNCT
aiua-13762	380	6	genes	gene	NOUN
aiua-13762	380	7	-	-	PUNCT
aiua-13762	380	8	hppdq#_589	hppdq#_589	NOUN
aiua-13762	380	9	.	.	PUNCT
aiua-13762	380	10	21	21	NUM
aiua-13762	380	11	.	.	PUNCT
aiua-13762	381	1	witte	witte	PROPN
aiua-13762	381	2	js	js	PROPN
aiua-13762	381	3	.	.	PUNCT
aiua-13762	382	1	prostate	prostate	NOUN
aiua-13762	382	2	cancer	cancer	NOUN
aiua-13762	382	3	genomics	genomic	NOUN
aiua-13762	382	4	:	:	PUNCT
aiua-13762	382	5	towards	towards	ADP
aiua-13762	382	6	a	a	DET
aiua-13762	382	7	new	new	ADJ
aiua-13762	382	8	understanding	understanding	NOUN
aiua-13762	382	9	.	.	PUNCT
aiua-13762	383	1	nat	nat	PROPN
aiua-13762	383	2	rev	rev	VERB
aiua-13762	383	3	genet	genet	PROPN
aiua-13762	383	4	2009	2009	NUM
aiua-13762	383	5	;	;	PUNCT
aiua-13762	383	6	10:77	10:77	NUM
aiua-13762	383	7	-	-	SYM
aiua-13762	383	8	82	82	NUM
aiua-13762	383	9	.	.	PUNCT
aiua-13762	384	1	22	22	NUM
aiua-13762	384	2	.	.	PUNCT
aiua-13762	385	1	farashi	farashi	PROPN
aiua-13762	385	2	s	s	PROPN
aiua-13762	385	3	,	,	PUNCT
aiua-13762	385	4	kryza	kryza	PROPN
aiua-13762	385	5	t	t	PROPN
aiua-13762	385	6	,	,	PUNCT
aiua-13762	385	7	clements	clements	PROPN
aiua-13762	385	8	j	j	PROPN
aiua-13762	385	9	,	,	PUNCT
aiua-13762	385	10	batra	batra	PROPN
aiua-13762	385	11	j.	j.	PROPN
aiua-13762	385	12	post	post	PROPN
aiua-13762	385	13	-	-	ADJ
aiua-13762	385	14	gwas	gwas	ADJ
aiua-13762	385	15	in	in	ADP
aiua-13762	385	16	prostate	prostate	NOUN
aiua-13762	385	17	cancer	cancer	NOUN
aiua-13762	385	18	:	:	PUNCT
aiua-13762	385	19	from	from	ADP
aiua-13762	385	20	genetic	genetic	ADJ
aiua-13762	385	21	association	association	NOUN
aiua-13762	385	22	to	to	ADP
aiua-13762	385	23	biological	biological	ADJ
aiua-13762	385	24	contribution	contribution	NOUN
aiua-13762	385	25	.	.	PUNCT
aiua-13762	386	1	nat	nat	PROPN
aiua-13762	386	2	rev	rev	VERB
aiua-13762	386	3	cancer	cancer	NOUN
aiua-13762	386	4	2019	2019	NUM
aiua-13762	386	5	;	;	PUNCT
aiua-13762	386	6	19:46	19:46	NUM
aiua-13762	386	7	-	-	SYM
aiua-13762	386	8	59	59	NUM
aiua-13762	386	9	.	.	PUNCT
aiua-13762	386	10	23	23	NUM
aiua-13762	386	11	.	.	PUNCT
aiua-13762	387	1	lynch	lynch	PROPN
aiua-13762	387	2	ht	ht	PROPN
aiua-13762	387	3	,	,	PUNCT
aiua-13762	387	4	kosoko	kosoko	PROPN
aiua-13762	387	5	-	-	PUNCT
aiua-13762	387	6	lasaki	lasaki	PROPN
aiua-13762	387	7	o	o	NOUN
aiua-13762	387	8	,	,	PUNCT
aiua-13762	387	9	leslie	leslie	PROPN
aiua-13762	387	10	sw	sw	PROPN
aiua-13762	387	11	,	,	PUNCT
aiua-13762	387	12	et	et	PROPN
aiua-13762	387	13	al	al	PROPN
aiua-13762	387	14	.	.	PUNCT
aiua-13762	387	15	screening	screen	VERB
aiua-13762	387	16	for	for	ADP
aiua-13762	387	17	familial	familial	ADJ
aiua-13762	387	18	and	and	CCONJ
aiua-13762	387	19	hereditary	hereditary	ADJ
aiua-13762	387	20	prostate	prostate	NOUN
aiua-13762	387	21	cancer	cancer	NOUN
aiua-13762	387	22	.	.	PUNCT
aiua-13762	388	1	int	int	PROPN
aiua-13762	388	2	j	j	PROPN
aiua-13762	388	3	cancer	cancer	NOUN
aiua-13762	388	4	2016	2016	NUM
aiua-13762	388	5	;	;	PUNCT
aiua-13762	388	6	138:2579	138:2579	NUM
aiua-13762	388	7	-	-	SYM
aiua-13762	388	8	91	91	NUM
aiua-13762	388	9	.	.	PUNCT
aiua-13762	388	10	24	24	NUM
aiua-13762	388	11	.	.	PUNCT
aiua-13762	389	1	simard	simard	PROPN
aiua-13762	389	2	j	j	PROPN
aiua-13762	389	3	,	,	PUNCT
aiua-13762	389	4	dumont	dumont	NOUN
aiua-13762	389	5	m	m	PROPN
aiua-13762	389	6	,	,	PUNCT
aiua-13762	389	7	soucy	soucy	PROPN
aiua-13762	389	8	p	p	NOUN
aiua-13762	389	9	,	,	PUNCT
aiua-13762	389	10	labrie	labrie	PROPN
aiua-13762	389	11	f.	f.	PROPN
aiua-13762	389	12	perspective	perspective	PROPN
aiua-13762	389	13	:	:	PUNCT
aiua-13762	389	14	prostate	prostate	NOUN
aiua-13762	389	15	cancer	cancer	NOUN
aiua-13762	389	16	susceptibility	susceptibility	NOUN
aiua-13762	389	17	genes	gene	NOUN
aiua-13762	389	18	.	.	PUNCT
aiua-13762	390	1	endocrinology	endocrinology	NOUN
aiua-13762	390	2	2002	2002	NUM
aiua-13762	390	3	;	;	PUNCT
aiua-13762	390	4	143:2029	143:2029	NUM
aiua-13762	390	5	-	-	SYM
aiua-13762	390	6	40	40	NUM
aiua-13762	390	7	.	.	PUNCT
aiua-13762	391	1	archivio	archivio	NOUN
aiua-13762	391	2	italiano	italiano	X
aiua-13762	391	3	di	di	PROPN
aiua-13762	391	4	urologia	urologia	PROPN
aiua-13762	391	5	e	e	PROPN
aiua-13762	391	6	andrologia	andrologia	NOUN
aiua-13762	391	7	2025	2025	NUM
aiua-13762	391	8	;	;	PUNCT
aiua-13762	391	9	97(2):13762	97(2):13762	NUM
aiua-13762	391	10	11	11	NUM
aiua-13762	391	11	genetic	genetic	ADJ
aiua-13762	391	12	of	of	ADP
aiua-13762	391	13	prostate	prostate	NOUN
aiua-13762	391	14	cancer	cancer	NOUN
aiua-13762	391	15	25	25	NUM
aiua-13762	391	16	.	.	PUNCT
aiua-13762	392	1	xu	xu	PROPN
aiua-13762	393	1	j	j	PROPN
aiua-13762	393	2	,	,	PUNCT
aiua-13762	393	3	zheng	zheng	PROPN
aiua-13762	393	4	sl	sl	PROPN
aiua-13762	393	5	,	,	PUNCT
aiua-13762	393	6	hawkins	hawkins	PROPN
aiua-13762	393	7	ga	ga	PROPN
aiua-13762	393	8	,	,	PUNCT
aiua-13762	393	9	et	et	PROPN
aiua-13762	393	10	al	al	PROPN
aiua-13762	393	11	.	.	PUNCT
aiua-13762	394	1	linkage	linkage	NOUN
aiua-13762	394	2	and	and	CCONJ
aiua-13762	394	3	association	association	NOUN
aiua-13762	394	4	studies	study	NOUN
aiua-13762	394	5	of	of	ADP
aiua-13762	394	6	prostate	prostate	NOUN
aiua-13762	394	7	cancer	cancer	NOUN
aiua-13762	394	8	susceptibility	susceptibility	NOUN
aiua-13762	394	9	:	:	PUNCT
aiua-13762	394	10	evidence	evidence	NOUN
aiua-13762	394	11	for	for	ADP
aiua-13762	394	12	linkage	linkage	NOUN
aiua-13762	394	13	at	at	ADP
aiua-13762	394	14	8p22	8p22	NOUN
aiua-13762	394	15	-	-	SYM
aiua-13762	394	16	23	23	NUM
aiua-13762	394	17	.	.	PUNCT
aiua-13762	394	18	am	be	AUX
aiua-13762	394	19	j	j	PROPN
aiua-13762	394	20	hum	hum	PROPN
aiua-13762	394	21	genet	genet	PROPN
aiua-13762	394	22	2001	2001	NUM
aiua-13762	394	23	;	;	PUNCT
aiua-13762	394	24	69:341	69:341	NUM
aiua-13762	394	25	-	-	SYM
aiua-13762	394	26	50	50	NUM
aiua-13762	394	27	.	.	NOUN
aiua-13762	395	1	26	26	NUM
aiua-13762	395	2	.	.	PUNCT
aiua-13762	396	1	alanee	alanee	PROPN
aiua-13762	396	2	s	s	PROPN
aiua-13762	396	3	,	,	PUNCT
aiua-13762	396	4	shah	shah	PROPN
aiua-13762	396	5	s	s	PROPN
aiua-13762	396	6	,	,	PUNCT
aiua-13762	396	7	vijai	vijai	PROPN
aiua-13762	396	8	j	j	PROPN
aiua-13762	396	9	,	,	PUNCT
aiua-13762	396	10	et	et	PROPN
aiua-13762	396	11	al	al	PROPN
aiua-13762	396	12	.	.	PUNCT
aiua-13762	397	1	prevalence	prevalence	NOUN
aiua-13762	397	2	of	of	ADP
aiua-13762	397	3	hoxb13	hoxb13	PROPN
aiua-13762	397	4	mutation	mutation	NOUN
aiua-13762	397	5	in	in	ADP
aiua-13762	397	6	a	a	DET
aiua-13762	397	7	population	population	NOUN
aiua-13762	397	8	of	of	ADP
aiua-13762	397	9	ashkenazi	ashkenazi	ADJ
aiua-13762	397	10	jewish	jewish	ADJ
aiua-13762	397	11	men	man	NOUN
aiua-13762	397	12	treated	treat	VERB
aiua-13762	397	13	for	for	ADP
aiua-13762	397	14	prostate	prostate	NOUN
aiua-13762	397	15	cancer	cancer	NOUN
aiua-13762	397	16	.	.	PUNCT
aiua-13762	398	1	fam	fam	NOUN
aiua-13762	398	2	cancer	cancer	NOUN
aiua-13762	398	3	2013	2013	NUM
aiua-13762	398	4	;	;	PUNCT
aiua-13762	398	5	12:597	12:597	NUM
aiua-13762	398	6	-	-	SYM
aiua-13762	398	7	600	600	NUM
aiua-13762	398	8	.	.	NOUN
aiua-13762	398	9	27	27	NUM
aiua-13762	398	10	.	.	PUNCT
aiua-13762	399	1	ewing	ewing	ADJ
aiua-13762	399	2	cm	cm	PROPN
aiua-13762	399	3	,	,	PUNCT
aiua-13762	399	4	ray	ray	PROPN
aiua-13762	399	5	am	am	PROPN
aiua-13762	399	6	,	,	PUNCT
aiua-13762	399	7	lange	lange	VERB
aiua-13762	399	8	em	em	PRON
aiua-13762	399	9	,	,	PUNCT
aiua-13762	399	10	et	et	PROPN
aiua-13762	399	11	al	al	PROPN
aiua-13762	399	12	.	.	PROPN
aiua-13762	400	1	germline	germline	NOUN
aiua-13762	400	2	mutations	mutation	NOUN
aiua-13762	400	3	in	in	ADP
aiua-13762	400	4	hoxb13	hoxb13	NOUN
aiua-13762	400	5	and	and	CCONJ
aiua-13762	400	6	prostate	prostate	NOUN
aiua-13762	400	7	-	-	PUNCT
aiua-13762	400	8	cancer	cancer	NOUN
aiua-13762	400	9	risk	risk	NOUN
aiua-13762	400	10	.	.	PUNCT
aiua-13762	401	1	n	n	CCONJ
aiua-13762	401	2	engl	engl	PROPN
aiua-13762	401	3	j	j	PROPN
aiua-13762	401	4	med	med	PROPN
aiua-13762	401	5	2012	2012	NUM
aiua-13762	401	6	;	;	PUNCT
aiua-13762	401	7	366:141	366:141	NUM
aiua-13762	401	8	-	-	SYM
aiua-13762	401	9	9	9	NUM
aiua-13762	401	10	.	.	NOUN
aiua-13762	401	11	28	28	NUM
aiua-13762	401	12	.	.	PUNCT
aiua-13762	402	1	friedrichsen	friedrichsen	PROPN
aiua-13762	402	2	dm	dm	PROPN
aiua-13762	402	3	,	,	PUNCT
aiua-13762	402	4	stanford	stanford	PROPN
aiua-13762	402	5	jl	jl	PROPN
aiua-13762	402	6	,	,	PUNCT
aiua-13762	402	7	isaacs	isaacs	PROPN
aiua-13762	402	8	sd	sd	PROPN
aiua-13762	402	9	,	,	PUNCT
aiua-13762	402	10	et	et	PROPN
aiua-13762	402	11	al	al	PROPN
aiua-13762	402	12	.	.	PUNCT
aiua-13762	402	13	identification	identification	NOUN
aiua-13762	402	14	of	of	ADP
aiua-13762	402	15	a	a	DET
aiua-13762	402	16	prostate	prostate	NOUN
aiua-13762	402	17	cancer	cancer	NOUN
aiua-13762	402	18	susceptibility	susceptibility	NOUN
aiua-13762	402	19	locus	locus	NOUN
aiua-13762	402	20	on	on	ADP
aiua-13762	402	21	chromosome	chromosome	NOUN
aiua-13762	402	22	7q11	7q11	NUM
aiua-13762	402	23	-	-	SYM
aiua-13762	402	24	21	21	NUM
aiua-13762	402	25	in	in	ADP
aiua-13762	402	26	jewish	jewish	ADJ
aiua-13762	402	27	families	family	NOUN
aiua-13762	402	28	.	.	PUNCT
aiua-13762	403	1	proc	proc	PROPN
aiua-13762	403	2	natl	natl	PROPN
aiua-13762	403	3	acad	acad	PROPN
aiua-13762	403	4	sci	sci	PROPN
aiua-13762	403	5	usa	usa	PROPN
aiua-13762	403	6	2004	2004	NUM
aiua-13762	403	7	;	;	PUNCT
aiua-13762	403	8	101:1939	101:1939	NUM
aiua-13762	403	9	-	-	SYM
aiua-13762	403	10	44	44	NUM
aiua-13762	403	11	.	.	PUNCT
aiua-13762	403	12	29	29	NUM
aiua-13762	403	13	.	.	PUNCT
aiua-13762	404	1	vijai	vijai	PROPN
aiua-13762	404	2	j	j	PROPN
aiua-13762	404	3	,	,	PUNCT
aiua-13762	404	4	kirchhoff	kirchhoff	PROPN
aiua-13762	404	5	t	t	PROPN
aiua-13762	404	6	,	,	PUNCT
aiua-13762	404	7	gallagher	gallagher	PROPN
aiua-13762	404	8	d	d	PROPN
aiua-13762	404	9	,	,	PUNCT
aiua-13762	404	10	et	et	PROPN
aiua-13762	404	11	al	al	PROPN
aiua-13762	404	12	.	.	PUNCT
aiua-13762	405	1	genetic	genetic	ADJ
aiua-13762	405	2	architecture	architecture	NOUN
aiua-13762	405	3	of	of	ADP
aiua-13762	405	4	prostate	prostate	NOUN
aiua-13762	405	5	cancer	cancer	NOUN
aiua-13762	405	6	in	in	ADP
aiua-13762	405	7	the	the	DET
aiua-13762	405	8	ashkenazi	ashkenazi	ADJ
aiua-13762	405	9	jewish	jewish	ADJ
aiua-13762	405	10	population	population	NOUN
aiua-13762	405	11	.	.	PUNCT
aiua-13762	406	1	br	br	PROPN
aiua-13762	406	2	j	j	PROPN
aiua-13762	406	3	cancer	cancer	PROPN
aiua-13762	406	4	2011	2011	NUM
aiua-13762	406	5	;	;	PUNCT
aiua-13762	406	6	105:864	105:864	NUM
aiua-13762	406	7	-	-	PUNCT
aiua-13762	406	8	9	9	NUM
aiua-13762	406	9	.	.	NOUN
aiua-13762	406	10	30	30	NUM
aiua-13762	406	11	.	.	PUNCT
aiua-13762	407	1	gallagher	gallagher	PROPN
aiua-13762	407	2	dj	dj	PROPN
aiua-13762	407	3	,	,	PUNCT
aiua-13762	407	4	vijai	vijai	PROPN
aiua-13762	407	5	j	j	PROPN
aiua-13762	407	6	,	,	PUNCT
aiua-13762	407	7	cronin	cronin	PROPN
aiua-13762	407	8	am	be	AUX
aiua-13762	407	9	,	,	PUNCT
aiua-13762	407	10	et	et	PROPN
aiua-13762	407	11	al	al	PROPN
aiua-13762	407	12	.	.	PROPN
aiua-13762	407	13	susceptibility	susceptibility	PROPN
aiua-13762	407	14	loci	loci	PROPN
aiua-13762	407	15	associated	associate	VERB
aiua-13762	407	16	with	with	ADP
aiua-13762	407	17	prostate	prostate	NOUN
aiua-13762	407	18	cancer	cancer	NOUN
aiua-13762	407	19	progression	progression	NOUN
aiua-13762	407	20	and	and	CCONJ
aiua-13762	407	21	mortality	mortality	NOUN
aiua-13762	407	22	.	.	PUNCT
aiua-13762	408	1	clin	clin	PROPN
aiua-13762	408	2	cancer	cancer	NOUN
aiua-13762	408	3	res	re	NOUN
aiua-13762	408	4	2010	2010	NUM
aiua-13762	408	5	;	;	PUNCT
aiua-13762	408	6	16:2819	16:2819	NUM
aiua-13762	408	7	-	-	SYM
aiua-13762	408	8	32	32	NUM
aiua-13762	408	9	.	.	PUNCT
aiua-13762	409	1	31	31	NUM
aiua-13762	409	2	.	.	PUNCT
aiua-13762	410	1	kuroki	kuroki	PROPN
aiua-13762	410	2	y	y	PROPN
aiua-13762	410	3	,	,	PUNCT
aiua-13762	410	4	fukami	fukami	PROPN
aiua-13762	410	5	m.	m.	NOUN
aiua-13762	411	1	y	y	PROPN
aiua-13762	411	2	chromosome	chromosome	VERB
aiua-13762	411	3	genomic	genomic	ADJ
aiua-13762	411	4	variations	variation	NOUN
aiua-13762	411	5	and	and	CCONJ
aiua-13762	411	6	biological	biological	ADJ
aiua-13762	411	7	significance	significance	NOUN
aiua-13762	411	8	in	in	ADP
aiua-13762	411	9	human	human	ADJ
aiua-13762	411	10	diseases	disease	NOUN
aiua-13762	411	11	and	and	CCONJ
aiua-13762	411	12	health	health	NOUN
aiua-13762	411	13	.	.	PUNCT
aiua-13762	412	1	cytogenet	cytogenet	NOUN
aiua-13762	412	2	genome	genome	NOUN
aiua-13762	412	3	res	re	NOUN
aiua-13762	412	4	2023	2023	NUM
aiua-13762	412	5	;	;	PUNCT
aiua-13762	412	6	163:5	163:5	NUM
aiua-13762	412	7	-	-	SYM
aiua-13762	412	8	13	13	NUM
aiua-13762	412	9	.	.	PUNCT
aiua-13762	412	10	32	32	NUM
aiua-13762	412	11	.	.	PUNCT
aiua-13762	413	1	wang	wang	PROPN
aiua-13762	413	2	z	z	PROPN
aiua-13762	413	3	,	,	PUNCT
aiua-13762	413	4	parikh	parikh	PROPN
aiua-13762	413	5	h	h	PROPN
aiua-13762	413	6	,	,	PUNCT
aiua-13762	413	7	jia	jia	PROPN
aiua-13762	413	8	j	j	PROPN
aiua-13762	413	9	,	,	PUNCT
aiua-13762	413	10	et	et	PROPN
aiua-13762	413	11	al	al	PROPN
aiua-13762	413	12	.	.	PUNCT
aiua-13762	414	1	y	y	PROPN
aiua-13762	414	2	chromosome	chromosome	NOUN
aiua-13762	414	3	haplogroups	haplogroup	NOUN
aiua-13762	414	4	and	and	CCONJ
aiua-13762	414	5	prostate	prostate	NOUN
aiua-13762	414	6	cancer	cancer	NOUN
aiua-13762	414	7	in	in	ADP
aiua-13762	414	8	populations	population	NOUN
aiua-13762	414	9	of	of	ADP
aiua-13762	414	10	european	european	ADJ
aiua-13762	414	11	and	and	CCONJ
aiua-13762	414	12	ashkenazi	ashkenazi	ADJ
aiua-13762	414	13	jewish	jewish	ADJ
aiua-13762	414	14	ancestry	ancestry	NOUN
aiua-13762	414	15	.	.	PUNCT
aiua-13762	415	1	hum	hum	PROPN
aiua-13762	415	2	genet	genet	PROPN
aiua-13762	415	3	2012	2012	NUM
aiua-13762	415	4	;	;	PUNCT
aiua-13762	415	5	131:1173	131:1173	NUM
aiua-13762	415	6	-	-	SYM
aiua-13762	415	7	85	85	NUM
aiua-13762	415	8	.	.	PUNCT
aiua-13762	415	9	33	33	NUM
aiua-13762	415	10	.	.	PUNCT
aiua-13762	416	1	álvarez	álvarez	NOUN
aiua-13762	416	2	-	-	PUNCT
aiua-13762	416	3	topete	topete	NOUN
aiua-13762	416	4	e	e	NOUN
aiua-13762	416	5	,	,	PUNCT
aiua-13762	416	6	torres	torre	NOUN
aiua-13762	416	7	-	-	PUNCT
aiua-13762	416	8	sánchez	sánchez	NOUN
aiua-13762	416	9	le	le	PROPN
aiua-13762	416	10	,	,	PUNCT
aiua-13762	416	11	hernández	hernández	PROPN
aiua-13762	416	12	-	-	PUNCT
aiua-13762	416	13	tobías	tobías	ADP
aiua-13762	416	14	ea	ea	PROPN
aiua-13762	416	15	,	,	PUNCT
aiua-13762	416	16	et	et	PROPN
aiua-13762	416	17	al	al	PROPN
aiua-13762	416	18	.	.	PUNCT
aiua-13762	417	1	circum	circum	PROPN
aiua-13762	417	2	-	-	PUNCT
aiua-13762	417	3	mediterranean	mediterranean	PROPN
aiua-13762	417	4	influence	influence	NOUN
aiua-13762	417	5	in	in	ADP
aiua-13762	417	6	the	the	DET
aiua-13762	417	7	y	y	PROPN
aiua-13762	417	8	-	-	PUNCT
aiua-13762	417	9	chromosome	chromosome	NOUN
aiua-13762	417	10	lineages	lineage	NOUN
aiua-13762	417	11	associated	associate	VERB
aiua-13762	417	12	with	with	ADP
aiua-13762	417	13	prostate	prostate	NOUN
aiua-13762	417	14	cancer	cancer	NOUN
aiua-13762	417	15	in	in	ADP
aiua-13762	417	16	mexican	mexican	ADJ
aiua-13762	417	17	men	man	NOUN
aiua-13762	417	18	:	:	PUNCT
aiua-13762	417	19	a	a	DET
aiua-13762	417	20	converso	converso	ADJ
aiua-13762	417	21	heritage	heritage	NOUN
aiua-13762	417	22	founder	founder	NOUN
aiua-13762	417	23	effect	effect	NOUN
aiua-13762	417	24	?	?	PUNCT
aiua-13762	418	1	plos	plos	PROPN
aiua-13762	418	2	one	one	NUM
aiua-13762	418	3	2024	2024	NUM
aiua-13762	418	4	;	;	PUNCT
aiua-13762	418	5	19	19	NUM
aiua-13762	418	6	:	:	PUNCT
aiua-13762	418	7	e0308092	e0308092	PROPN
aiua-13762	418	8	.	.	PUNCT
aiua-13762	418	9	34	34	NUM
aiua-13762	418	10	.	.	PUNCT
aiua-13762	419	1	tofanelli	tofanelli	PROPN
aiua-13762	419	2	s	s	PROPN
aiua-13762	419	3	,	,	PUNCT
aiua-13762	419	4	taglioli	taglioli	PROPN
aiua-13762	419	5	l	l	NOUN
aiua-13762	419	6	,	,	PUNCT
aiua-13762	419	7	bertoncini	bertoncini	PROPN
aiua-13762	419	8	s	s	PROPN
aiua-13762	419	9	,	,	PUNCT
aiua-13762	419	10	et	et	PROPN
aiua-13762	419	11	al	al	PROPN
aiua-13762	419	12	.	.	PROPN
aiua-13762	419	13	mitochondrial	mitochondrial	PROPN
aiua-13762	419	14	and	and	CCONJ
aiua-13762	419	15	y	y	PROPN
aiua-13762	419	16	chromosome	chromosome	NOUN
aiua-13762	419	17	haplotype	haplotype	NOUN
aiua-13762	419	18	motifs	motif	NOUN
aiua-13762	419	19	as	as	ADP
aiua-13762	419	20	diagnostic	diagnostic	ADJ
aiua-13762	419	21	markers	marker	NOUN
aiua-13762	419	22	of	of	ADP
aiua-13762	419	23	jewish	jewish	ADJ
aiua-13762	419	24	ancestry	ancestry	NOUN
aiua-13762	419	25	:	:	PUNCT
aiua-13762	419	26	a	a	DET
aiua-13762	419	27	reconsideration	reconsideration	NOUN
aiua-13762	419	28	.	.	PUNCT
aiua-13762	420	1	front	front	ADJ
aiua-13762	420	2	genet	genet	PROPN
aiua-13762	420	3	2014	2014	NUM
aiua-13762	420	4	;	;	PUNCT
aiua-13762	420	5	5:384	5:384	NUM
aiua-13762	420	6	.	.	NOUN
aiua-13762	420	7	35	35	NUM
aiua-13762	420	8	.	.	PUNCT
aiua-13762	421	1	smith	smith	PROPN
aiua-13762	421	2	jr	jr	PROPN
aiua-13762	421	3	,	,	PUNCT
aiua-13762	421	4	catovsky	catovsky	PROPN
aiua-13762	421	5	d	d	NOUN
aiua-13762	421	6	,	,	PUNCT
aiua-13762	421	7	freije	freije	NOUN
aiua-13762	421	8	d	d	NOUN
aiua-13762	421	9	,	,	PUNCT
aiua-13762	421	10	et	et	PROPN
aiua-13762	421	11	al	al	PROPN
aiua-13762	421	12	.	.	PUNCT
aiua-13762	422	1	major	major	ADJ
aiua-13762	422	2	susceptibility	susceptibility	NOUN
aiua-13762	422	3	locus	locus	NOUN
aiua-13762	422	4	for	for	ADP
aiua-13762	422	5	prostate	prostate	NOUN
aiua-13762	422	6	cancer	cancer	NOUN
aiua-13762	422	7	on	on	ADP
aiua-13762	422	8	chromosome	chromosome	NOUN
aiua-13762	422	9	1	1	NUM
aiua-13762	422	10	suggested	suggest	VERB
aiua-13762	422	11	by	by	ADP
aiua-13762	422	12	a	a	DET
aiua-13762	422	13	genome	genome	NOUN
aiua-13762	422	14	-	-	PUNCT
aiua-13762	422	15	wide	wide	ADJ
aiua-13762	422	16	search	search	NOUN
aiua-13762	422	17	.	.	PUNCT
aiua-13762	423	1	science	science	NOUN
aiua-13762	423	2	1996	1996	NUM
aiua-13762	423	3	;	;	PUNCT
aiua-13762	423	4	274:1371	274:1371	NUM
aiua-13762	423	5	-	-	SYM
aiua-13762	423	6	4	4	NUM
aiua-13762	423	7	.	.	NUM
aiua-13762	423	8	36	36	NUM
aiua-13762	423	9	.	.	PUNCT
aiua-13762	424	1	xu	xu	PROPN
aiua-13762	424	2	j	j	PROPN
aiua-13762	424	3	,	,	PUNCT
aiua-13762	424	4	meyers	meyers	PROPN
aiua-13762	424	5	d	d	PROPN
aiua-13762	424	6	,	,	PUNCT
aiua-13762	424	7	freije	freije	NOUN
aiua-13762	424	8	d	d	NOUN
aiua-13762	424	9	,	,	PUNCT
aiua-13762	424	10	et	et	PROPN
aiua-13762	424	11	al	al	PROPN
aiua-13762	424	12	.	.	PROPN
aiua-13762	424	13	evidence	evidence	NOUN
aiua-13762	424	14	for	for	ADP
aiua-13762	424	15	a	a	DET
aiua-13762	424	16	prostate	prostate	NOUN
aiua-13762	424	17	cancer	cancer	NOUN
aiua-13762	424	18	susceptibility	susceptibility	NOUN
aiua-13762	424	19	locus	locus	NOUN
aiua-13762	424	20	on	on	ADP
aiua-13762	424	21	the	the	DET
aiua-13762	424	22	x	x	ADJ
aiua-13762	424	23	chromosome	chromosome	NOUN
aiua-13762	424	24	.	.	PUNCT
aiua-13762	425	1	nat	nat	PROPN
aiua-13762	425	2	genet	genet	PROPN
aiua-13762	425	3	1998	1998	NUM
aiua-13762	425	4	;	;	PUNCT
aiua-13762	425	5	20:175	20:175	NUM
aiua-13762	425	6	-	-	SYM
aiua-13762	425	7	9	9	NUM
aiua-13762	425	8	.	.	NOUN
aiua-13762	425	9	37	37	NUM
aiua-13762	425	10	.	.	PUNCT
aiua-13762	426	1	bailey	bailey	PROPN
aiua-13762	426	2	-	-	PUNCT
aiua-13762	426	3	wilson	wilson	PROPN
aiua-13762	426	4	je	je	PROPN
aiua-13762	426	5	,	,	PUNCT
aiua-13762	426	6	childs	child	VERB
aiua-13762	426	7	ej	ej	PROPN
aiua-13762	426	8	,	,	PUNCT
aiua-13762	426	9	cropp	cropp	PROPN
aiua-13762	426	10	cd	cd	PROPN
aiua-13762	426	11	,	,	PUNCT
aiua-13762	426	12	et	et	PROPN
aiua-13762	426	13	al	al	PROPN
aiua-13762	426	14	.	.	PUNCT
aiua-13762	427	1	analysis	analysis	NOUN
aiua-13762	427	2	of	of	ADP
aiua-13762	427	3	xq2728	xq2728	PROPN
aiua-13762	427	4	linkage	linkage	NOUN
aiua-13762	427	5	in	in	ADP
aiua-13762	427	6	the	the	DET
aiua-13762	427	7	international	international	ADJ
aiua-13762	427	8	consortium	consortium	NOUN
aiua-13762	427	9	for	for	ADP
aiua-13762	427	10	prostate	prostate	NOUN
aiua-13762	427	11	cancer	cancer	NOUN
aiua-13762	427	12	genetics	genetic	NOUN
aiua-13762	427	13	(	(	PUNCT
aiua-13762	427	14	icpcg	icpcg	NOUN
aiua-13762	427	15	)	)	PUNCT
aiua-13762	427	16	families	family	NOUN
aiua-13762	427	17	.	.	PUNCT
aiua-13762	428	1	bmc	bmc	PROPN
aiua-13762	428	2	med	med	ADJ
aiua-13762	428	3	genet	genet	PROPN
aiua-13762	428	4	2012	2012	NUM
aiua-13762	428	5	;	;	PUNCT
aiua-13762	429	1	13:46	13:46	NUM
aiua-13762	429	2	.	.	PUNCT
aiua-13762	430	1	38	38	NUM
aiua-13762	430	2	.	.	PUNCT
aiua-13762	431	1	carpten	carpten	PROPN
aiua-13762	431	2	j	j	PROPN
aiua-13762	431	3	,	,	PUNCT
aiua-13762	431	4	nupponen	nupponen	PROPN
aiua-13762	431	5	n	n	PROPN
aiua-13762	431	6	,	,	PUNCT
aiua-13762	431	7	isaacs	isaacs	PROPN
aiua-13762	431	8	s	s	PART
aiua-13762	431	9	,	,	PUNCT
aiua-13762	431	10	et	et	PROPN
aiua-13762	431	11	al	al	PROPN
aiua-13762	431	12	.	.	PROPN
aiua-13762	432	1	germline	germline	NOUN
aiua-13762	432	2	mutations	mutation	NOUN
aiua-13762	432	3	in	in	ADP
aiua-13762	432	4	the	the	DET
aiua-13762	432	5	ribonuclease	ribonuclease	NOUN
aiua-13762	432	6	l	l	NOUN
aiua-13762	432	7	gene	gene	NOUN
aiua-13762	432	8	in	in	ADP
aiua-13762	432	9	families	family	NOUN
aiua-13762	432	10	showing	show	VERB
aiua-13762	432	11	linkage	linkage	NOUN
aiua-13762	432	12	with	with	ADP
aiua-13762	432	13	hpc1	hpc1	PROPN
aiua-13762	432	14	.	.	PUNCT
aiua-13762	433	1	nat	nat	PROPN
aiua-13762	433	2	genet	genet	PROPN
aiua-13762	433	3	2002	2002	NUM
aiua-13762	433	4	;	;	PUNCT
aiua-13762	433	5	30:181	30:181	NUM
aiua-13762	433	6	-	-	SYM
aiua-13762	433	7	4	4	NUM
aiua-13762	433	8	.	.	NOUN
aiua-13762	433	9	39	39	NUM
aiua-13762	433	10	.	.	PUNCT
aiua-13762	434	1	nakazato	nakazato	PROPN
aiua-13762	434	2	h	h	PROPN
aiua-13762	434	3	,	,	PUNCT
aiua-13762	434	4	suzuki	suzuki	PROPN
aiua-13762	434	5	k	k	PROPN
aiua-13762	434	6	,	,	PUNCT
aiua-13762	434	7	matsui	matsui	PROPN
aiua-13762	434	8	h	h	PROPN
aiua-13762	434	9	,	,	PUNCT
aiua-13762	434	10	et	et	PROPN
aiua-13762	434	11	al	al	PROPN
aiua-13762	434	12	.	.	PUNCT
aiua-13762	435	1	role	role	NOUN
aiua-13762	435	2	of	of	ADP
aiua-13762	435	3	genetic	genetic	ADJ
aiua-13762	435	4	polymorphisms	polymorphism	NOUN
aiua-13762	435	5	of	of	ADP
aiua-13762	435	6	the	the	DET
aiua-13762	435	7	rnasel	rnasel	NOUN
aiua-13762	435	8	gene	gene	NOUN
aiua-13762	435	9	on	on	ADP
aiua-13762	435	10	familial	familial	ADJ
aiua-13762	435	11	prostate	prostate	NOUN
aiua-13762	435	12	cancer	cancer	NOUN
aiua-13762	435	13	risk	risk	NOUN
aiua-13762	435	14	in	in	ADP
aiua-13762	435	15	a	a	DET
aiua-13762	435	16	japanese	japanese	ADJ
aiua-13762	435	17	population	population	NOUN
aiua-13762	435	18	.	.	PUNCT
aiua-13762	436	1	br	br	PROPN
aiua-13762	436	2	j	j	PROPN
aiua-13762	436	3	cancer	cancer	PROPN
aiua-13762	436	4	2003	2003	NUM
aiua-13762	436	5	;	;	PUNCT
aiua-13762	436	6	89:691	89:691	NUM
aiua-13762	436	7	-	-	SYM
aiua-13762	436	8	6	6	NUM
aiua-13762	436	9	.	.	NUM
aiua-13762	436	10	40	40	NUM
aiua-13762	436	11	.	.	PUNCT
aiua-13762	437	1	meyer	meyer	PROPN
aiua-13762	437	2	ms	ms	PROPN
aiua-13762	437	3	,	,	PUNCT
aiua-13762	437	4	penney	penney	PROPN
aiua-13762	437	5	kl	kl	PROPN
aiua-13762	437	6	,	,	PUNCT
aiua-13762	437	7	stark	stark	PROPN
aiua-13762	437	8	jr	jr	PROPN
aiua-13762	437	9	,	,	PUNCT
aiua-13762	437	10	et	et	PROPN
aiua-13762	437	11	al	al	PROPN
aiua-13762	437	12	.	.	PUNCT
aiua-13762	438	1	genetic	genetic	ADJ
aiua-13762	438	2	variation	variation	NOUN
aiua-13762	438	3	in	in	ADP
aiua-13762	438	4	rnasel	rnasel	NOUN
aiua-13762	438	5	associated	associate	VERB
aiua-13762	438	6	with	with	ADP
aiua-13762	438	7	prostate	prostate	NOUN
aiua-13762	438	8	cancer	cancer	NOUN
aiua-13762	438	9	risk	risk	NOUN
aiua-13762	438	10	and	and	CCONJ
aiua-13762	438	11	progression	progression	NOUN
aiua-13762	438	12	.	.	PUNCT
aiua-13762	439	1	carcinogenesis	carcinogenesis	NOUN
aiua-13762	439	2	2010	2010	NUM
aiua-13762	439	3	;	;	PUNCT
aiua-13762	439	4	31:1597	31:1597	PROPN
aiua-13762	439	5	-	-	SYM
aiua-13762	439	6	603	603	NUM
aiua-13762	439	7	.	.	PUNCT
aiua-13762	439	8	41	41	NUM
aiua-13762	439	9	.	.	PUNCT
aiua-13762	440	1	rökman	rökman	PROPN
aiua-13762	440	2	a	a	PRON
aiua-13762	440	3	,	,	PUNCT
aiua-13762	440	4	ikonen	ikonen	PROPN
aiua-13762	440	5	t	t	PROPN
aiua-13762	440	6	,	,	PUNCT
aiua-13762	440	7	seppälä	seppälä	NOUN
aiua-13762	440	8	eh	eh	INTJ
aiua-13762	440	9	,	,	PUNCT
aiua-13762	440	10	et	et	PROPN
aiua-13762	440	11	al	al	PROPN
aiua-13762	440	12	.	.	PROPN
aiua-13762	441	1	germline	germline	NOUN
aiua-13762	441	2	alterations	alteration	NOUN
aiua-13762	441	3	of	of	ADP
aiua-13762	441	4	the	the	DET
aiua-13762	441	5	rnasel	rnasel	NOUN
aiua-13762	441	6	gene	gene	NOUN
aiua-13762	441	7	,	,	PUNCT
aiua-13762	441	8	a	a	DET
aiua-13762	441	9	candidate	candidate	NOUN
aiua-13762	441	10	hpc1	hpc1	NOUN
aiua-13762	441	11	gene	gene	NOUN
aiua-13762	441	12	at	at	ADP
aiua-13762	441	13	1q25	1q25	NUM
aiua-13762	441	14	,	,	PUNCT
aiua-13762	441	15	in	in	ADP
aiua-13762	441	16	patients	patient	NOUN
aiua-13762	441	17	and	and	CCONJ
aiua-13762	441	18	families	family	NOUN
aiua-13762	441	19	with	with	ADP
aiua-13762	441	20	prostate	prostate	NOUN
aiua-13762	441	21	cancer	cancer	NOUN
aiua-13762	441	22	.	.	PUNCT
aiua-13762	442	1	am	be	AUX
aiua-13762	442	2	j	j	PROPN
aiua-13762	442	3	hum	hum	PROPN
aiua-13762	442	4	genet	genet	PROPN
aiua-13762	442	5	2002	2002	NUM
aiua-13762	442	6	;	;	PUNCT
aiua-13762	442	7	70:1299	70:1299	X
aiua-13762	442	8	-	-	SYM
aiua-13762	442	9	304	304	NUM
aiua-13762	442	10	.	.	PUNCT
aiua-13762	443	1	42	42	NUM
aiua-13762	443	2	.	.	PUNCT
aiua-13762	444	1	orr	orr	NOUN
aiua-13762	444	2	-	-	PUNCT
aiua-13762	444	3	urtreger	urtreger	NOUN
aiua-13762	444	4	a	a	DET
aiua-13762	444	5	,	,	PUNCT
aiua-13762	444	6	bar	bar	NOUN
aiua-13762	444	7	-	-	PUNCT
aiua-13762	444	8	shira	shira	NOUN
aiua-13762	444	9	a	a	X
aiua-13762	444	10	,	,	PUNCT
aiua-13762	444	11	bercovich	bercovich	PROPN
aiua-13762	444	12	d	d	PROPN
aiua-13762	444	13	,	,	PUNCT
aiua-13762	444	14	et	et	PROPN
aiua-13762	444	15	al	al	PROPN
aiua-13762	444	16	.	.	PROPN
aiua-13762	444	17	rnasel	rnasel	NOUN
aiua-13762	444	18	mutation	mutation	NOUN
aiua-13762	444	19	screening	screening	NOUN
aiua-13762	444	20	and	and	CCONJ
aiua-13762	444	21	association	association	NOUN
aiua-13762	444	22	study	study	NOUN
aiua-13762	444	23	in	in	ADP
aiua-13762	444	24	ashkenazi	ashkenazi	ADJ
aiua-13762	444	25	and	and	CCONJ
aiua-13762	444	26	non	non	ADJ
aiua-13762	444	27	-	-	ADJ
aiua-13762	444	28	ashkenazi	ashkenazi	ADJ
aiua-13762	444	29	prostate	prostate	NOUN
aiua-13762	444	30	cancer	cancer	NOUN
aiua-13762	444	31	patients	patient	NOUN
aiua-13762	444	32	.	.	PUNCT
aiua-13762	445	1	cancer	cancer	NOUN
aiua-13762	445	2	epidemiol	epidemiol	PROPN
aiua-13762	445	3	biomarkers	biomarker	NOUN
aiua-13762	445	4	prev	prev	VERB
aiua-13762	445	5	2006	2006	NUM
aiua-13762	445	6	;	;	PUNCT
aiua-13762	445	7	15:474	15:474	NUM
aiua-13762	445	8	-	-	SYM
aiua-13762	445	9	9	9	NUM
aiua-13762	445	10	.	.	NOUN
aiua-13762	445	11	43	43	NUM
aiua-13762	445	12	.	.	PUNCT
aiua-13762	446	1	rennert	rennert	PROPN
aiua-13762	446	2	h	h	PROPN
aiua-13762	446	3	,	,	PUNCT
aiua-13762	446	4	bercovich	bercovich	PROPN
aiua-13762	446	5	d	d	PROPN
aiua-13762	446	6	,	,	PUNCT
aiua-13762	446	7	hubert	hubert	PROPN
aiua-13762	446	8	a	a	PROPN
aiua-13762	446	9	,	,	PUNCT
aiua-13762	446	10	et	et	PROPN
aiua-13762	446	11	al	al	PROPN
aiua-13762	446	12	.	.	PUNCT
aiua-13762	447	1	a	a	DET
aiua-13762	447	2	novel	novel	ADJ
aiua-13762	447	3	founder	founder	NOUN
aiua-13762	447	4	mutation	mutation	NOUN
aiua-13762	447	5	in	in	ADP
aiua-13762	447	6	the	the	DET
aiua-13762	447	7	rnasel	rnasel	NOUN
aiua-13762	447	8	gene	gene	NOUN
aiua-13762	447	9	,	,	PUNCT
aiua-13762	447	10	471delaaag	471delaaag	PROPN
aiua-13762	447	11	,	,	PUNCT
aiua-13762	447	12	is	be	AUX
aiua-13762	447	13	associated	associate	VERB
aiua-13762	447	14	with	with	ADP
aiua-13762	447	15	prostate	prostate	NOUN
aiua-13762	447	16	cancer	cancer	NOUN
aiua-13762	447	17	in	in	ADP
aiua-13762	447	18	ashkenazi	ashkenazi	ADJ
aiua-13762	447	19	jews	jews	PROPN
aiua-13762	447	20	.	.	PUNCT
aiua-13762	448	1	am	be	AUX
aiua-13762	448	2	j	j	PROPN
aiua-13762	448	3	hum	hum	PROPN
aiua-13762	448	4	genet	genet	PROPN
aiua-13762	448	5	2002	2002	NUM
aiua-13762	448	6	;	;	PUNCT
aiua-13762	448	7	71:981	71:981	NUM
aiua-13762	448	8	-	-	SYM
aiua-13762	448	9	4	4	NUM
aiua-13762	448	10	.	.	NUM
aiua-13762	448	11	44	44	NUM
aiua-13762	448	12	.	.	PUNCT
aiua-13762	449	1	kotar	kotar	PROPN
aiua-13762	449	2	k	k	PROPN
aiua-13762	449	3	,	,	PUNCT
aiua-13762	449	4	hamel	hamel	PROPN
aiua-13762	449	5	n	n	CCONJ
aiua-13762	449	6	,	,	PUNCT
aiua-13762	449	7	thiffault	thiffault	PROPN
aiua-13762	450	1	i	i	PROPN
aiua-13762	450	2	,	,	PUNCT
aiua-13762	450	3	foulkes	foulkes	PROPN
aiua-13762	450	4	wd	wd	PROPN
aiua-13762	450	5	.	.	PUNCT
aiua-13762	451	1	the	the	DET
aiua-13762	451	2	rnasel	rnasel	NOUN
aiua-13762	451	3	471delaaag	471delaaag	PROPN
aiua-13762	451	4	allele	allele	NOUN
aiua-13762	451	5	and	and	CCONJ
aiua-13762	451	6	prostate	prostate	NOUN
aiua-13762	451	7	cancer	cancer	NOUN
aiua-13762	451	8	in	in	ADP
aiua-13762	451	9	ashkenazi	ashkenazi	ADJ
aiua-13762	451	10	jewish	jewish	ADJ
aiua-13762	451	11	men	man	NOUN
aiua-13762	451	12	.	.	PUNCT
aiua-13762	452	1	j	j	PROPN
aiua-13762	452	2	med	med	PROPN
aiua-13762	452	3	genet	genet	PROPN
aiua-13762	452	4	2003	2003	NUM
aiua-13762	452	5	;	;	PUNCT
aiua-13762	452	6	40	40	NUM
aiua-13762	452	7	:	:	PUNCT
aiua-13762	452	8	e22	e22	NOUN
aiua-13762	452	9	.	.	PUNCT
aiua-13762	453	1	45	45	NUM
aiua-13762	453	2	.	.	PUNCT
aiua-13762	454	1	dagan	dagan	PROPN
aiua-13762	454	2	e	e	PROPN
aiua-13762	454	3	,	,	PUNCT
aiua-13762	454	4	laitman	laitman	PROPN
aiua-13762	454	5	y	y	PROPN
aiua-13762	454	6	,	,	PUNCT
aiua-13762	454	7	levanon	levanon	PROPN
aiua-13762	454	8	n	n	CCONJ
aiua-13762	454	9	,	,	PUNCT
aiua-13762	454	10	et	et	PROPN
aiua-13762	454	11	al	al	PROPN
aiua-13762	454	12	.	.	PUNCT
aiua-13762	455	1	the	the	DET
aiua-13762	455	2	471delaaag	471delaaag	PROPN
aiua-13762	455	3	mutation	mutation	NOUN
aiua-13762	455	4	and	and	CCONJ
aiua-13762	455	5	c353	c353	PROPN
aiua-13762	455	6	t	t	NOUN
aiua-13762	455	7	polymorphism	polymorphism	NOUN
aiua-13762	455	8	in	in	ADP
aiua-13762	455	9	the	the	DET
aiua-13762	455	10	rnasel	rnasel	NOUN
aiua-13762	455	11	gene	gene	NOUN
aiua-13762	455	12	in	in	ADP
aiua-13762	455	13	sporadic	sporadic	ADJ
aiua-13762	455	14	and	and	CCONJ
aiua-13762	455	15	inherited	inherit	VERB
aiua-13762	455	16	cancer	cancer	NOUN
aiua-13762	455	17	in	in	ADP
aiua-13762	455	18	israel	israel	PROPN
aiua-13762	455	19	.	.	PUNCT
aiua-13762	456	1	fam	fam	PROPN
aiua-13762	456	2	cancer	cancer	PROPN
aiua-13762	456	3	2006	2006	NUM
aiua-13762	456	4	;	;	PUNCT
aiua-13762	456	5	5:389	5:389	NUM
aiua-13762	456	6	-	-	SYM
aiua-13762	456	7	95	95	NUM
aiua-13762	456	8	.	.	PUNCT
aiua-13762	457	1	46	46	NUM
aiua-13762	457	2	.	.	PUNCT
aiua-13762	457	3	agalliu	agalliu	PROPN
aiua-13762	457	4	i	i	PRON
aiua-13762	457	5	,	,	PUNCT
aiua-13762	457	6	leanza	leanza	PROPN
aiua-13762	457	7	sm	sm	PROPN
aiua-13762	457	8	,	,	PUNCT
aiua-13762	457	9	smith	smith	PROPN
aiua-13762	457	10	l	l	PROPN
aiua-13762	457	11	,	,	PUNCT
aiua-13762	458	1	et	et	PROPN
aiua-13762	458	2	al	al	PROPN
aiua-13762	458	3	.	.	PROPN
aiua-13762	458	4	contribution	contribution	NOUN
aiua-13762	458	5	of	of	ADP
aiua-13762	458	6	hpc1	hpc1	PROPN
aiua-13762	458	7	(	(	PUNCT
aiua-13762	458	8	rnasel	rnasel	NOUN
aiua-13762	458	9	)	)	PUNCT
aiua-13762	458	10	and	and	CCONJ
aiua-13762	458	11	hpcx	hpcx	VERB
aiua-13762	458	12	variants	variant	NOUN
aiua-13762	458	13	to	to	PART
aiua-13762	458	14	prostate	prostate	VERB
aiua-13762	458	15	cancer	cancer	NOUN
aiua-13762	458	16	in	in	ADP
aiua-13762	458	17	a	a	DET
aiua-13762	458	18	founder	founder	NOUN
aiua-13762	458	19	population	population	NOUN
aiua-13762	458	20	.	.	PUNCT
aiua-13762	459	1	prostate	prostate	NOUN
aiua-13762	459	2	2010	2010	NUM
aiua-13762	459	3	;	;	PUNCT
aiua-13762	459	4	70:1716	70:1716	NOUN
aiua-13762	459	5	-	-	SYM
aiua-13762	459	6	27	27	NUM
aiua-13762	459	7	.	.	PUNCT
aiua-13762	459	8	47	47	NUM
aiua-13762	459	9	.	.	PUNCT
aiua-13762	460	1	shah	shah	PROPN
aiua-13762	460	2	s	s	PROPN
aiua-13762	460	3	,	,	PUNCT
aiua-13762	460	4	rachmat	rachmat	ADJ
aiua-13762	460	5	r	r	NOUN
aiua-13762	460	6	,	,	PUNCT
aiua-13762	460	7	enyioma	enyioma	ADJ
aiua-13762	460	8	s	s	PROPN
aiua-13762	460	9	,	,	PUNCT
aiua-13762	460	10	et	et	PROPN
aiua-13762	460	11	al	al	PROPN
aiua-13762	460	12	.	.	PUNCT
aiua-13762	461	1	brca	brca	PROPN
aiua-13762	461	2	mutations	mutation	NOUN
aiua-13762	461	3	in	in	ADP
aiua-13762	461	4	prostate	prostate	NOUN
aiua-13762	461	5	cancer	cancer	NOUN
aiua-13762	461	6	:	:	PUNCT
aiua-13762	461	7	assessment	assessment	NOUN
aiua-13762	461	8	,	,	PUNCT
aiua-13762	461	9	implications	implication	NOUN
aiua-13762	461	10	and	and	CCONJ
aiua-13762	461	11	treatment	treatment	NOUN
aiua-13762	461	12	considerations	consideration	NOUN
aiua-13762	461	13	.	.	PUNCT
aiua-13762	462	1	int	int	PROPN
aiua-13762	462	2	j	j	PROPN
aiua-13762	462	3	mol	mol	ADP
aiua-13762	462	4	sci	sci	PROPN
aiua-13762	462	5	2021	2021	NUM
aiua-13762	462	6	;	;	PUNCT
aiua-13762	462	7	22:12628	22:12628	NUM
aiua-13762	462	8	.	.	PUNCT
aiua-13762	463	1	48	48	NUM
aiua-13762	463	2	.	.	PUNCT
aiua-13762	464	1	park	park	PROPN
aiua-13762	464	2	jj	jj	PROPN
aiua-13762	464	3	,	,	PUNCT
aiua-13762	464	4	irvine	irvine	PROPN
aiua-13762	464	5	ra	ra	PROPN
aiua-13762	464	6	,	,	PUNCT
aiua-13762	464	7	buchanan	buchanan	PROPN
aiua-13762	464	8	g	g	PROPN
aiua-13762	464	9	,	,	PUNCT
aiua-13762	464	10	et	et	PROPN
aiua-13762	464	11	al	al	PROPN
aiua-13762	464	12	.	.	PUNCT
aiua-13762	464	13	breast	breast	NOUN
aiua-13762	464	14	cancer	cancer	NOUN
aiua-13762	464	15	susceptibility	susceptibility	NOUN
aiua-13762	464	16	gene	gene	NOUN
aiua-13762	464	17	1	1	NUM
aiua-13762	464	18	(	(	PUNCT
aiua-13762	464	19	brca1	brca1	NOUN
aiua-13762	464	20	)	)	PUNCT
aiua-13762	464	21	is	be	AUX
aiua-13762	464	22	a	a	DET
aiua-13762	464	23	coactivator	coactivator	NOUN
aiua-13762	464	24	of	of	ADP
aiua-13762	464	25	the	the	DET
aiua-13762	464	26	androgen	androgen	NOUN
aiua-13762	464	27	receptor	receptor	NOUN
aiua-13762	464	28	.	.	PUNCT
aiua-13762	465	1	cancer	cancer	NOUN
aiua-13762	465	2	res	re	NOUN
aiua-13762	465	3	2000	2000	NUM
aiua-13762	465	4	;	;	PUNCT
aiua-13762	465	5	60:5946	60:5946	NOUN
aiua-13762	465	6	-	-	SYM
aiua-13762	465	7	9	9	NUM
aiua-13762	465	8	.	.	NOUN
aiua-13762	465	9	49	49	NUM
aiua-13762	465	10	.	.	PUNCT
aiua-13762	466	1	grönberg	grönberg	PROPN
aiua-13762	466	2	h	h	PROPN
aiua-13762	466	3	,	,	PUNCT
aiua-13762	466	4	ahman	ahman	PROPN
aiua-13762	466	5	ak	ak	PROPN
aiua-13762	466	6	,	,	PUNCT
aiua-13762	466	7	emanuelsson	emanuelsson	PROPN
aiua-13762	466	8	m	m	PROPN
aiua-13762	466	9	,	,	PUNCT
aiua-13762	466	10	et	et	PROPN
aiua-13762	466	11	al	al	PROPN
aiua-13762	466	12	.	.	PUNCT
aiua-13762	467	1	brca2	brca2	PROPN
aiua-13762	467	2	mutation	mutation	NOUN
aiua-13762	467	3	in	in	ADP
aiua-13762	467	4	a	a	DET
aiua-13762	467	5	family	family	NOUN
aiua-13762	467	6	with	with	ADP
aiua-13762	467	7	hereditary	hereditary	ADJ
aiua-13762	467	8	prostate	prostate	NOUN
aiua-13762	467	9	cancer	cancer	NOUN
aiua-13762	467	10	.	.	PUNCT
aiua-13762	468	1	genes	gene	NOUN
aiua-13762	468	2	chromosomes	chromosome	NOUN
aiua-13762	468	3	cancer	cancer	NOUN
aiua-13762	468	4	2001	2001	NUM
aiua-13762	468	5	;	;	PUNCT
aiua-13762	468	6	30:299	30:299	NUM
aiua-13762	468	7	-	-	SYM
aiua-13762	468	8	301	301	NUM
aiua-13762	468	9	.	.	PUNCT
aiua-13762	468	10	50	50	NUM
aiua-13762	468	11	.	.	PUNCT
aiua-13762	469	1	lecarpentier	lecarpentier	PROPN
aiua-13762	469	2	j	j	PROPN
aiua-13762	469	3	,	,	PUNCT
aiua-13762	469	4	silvestri	silvestri	PROPN
aiua-13762	469	5	v	v	PROPN
aiua-13762	469	6	,	,	PUNCT
aiua-13762	469	7	kuchenbaecker	kuchenbaecker	PROPN
aiua-13762	469	8	kb	kb	PROPN
aiua-13762	469	9	,	,	PUNCT
aiua-13762	469	10	et	et	PROPN
aiua-13762	469	11	al	al	PROPN
aiua-13762	469	12	.	.	PROPN
aiua-13762	469	13	prediction	prediction	NOUN
aiua-13762	469	14	of	of	ADP
aiua-13762	469	15	breast	breast	NOUN
aiua-13762	469	16	and	and	CCONJ
aiua-13762	469	17	prostate	prostate	NOUN
aiua-13762	469	18	cancer	cancer	NOUN
aiua-13762	469	19	risks	risk	NOUN
aiua-13762	469	20	in	in	ADP
aiua-13762	469	21	male	male	ADJ
aiua-13762	469	22	brca1	brca1	NOUN
aiua-13762	469	23	and	and	CCONJ
aiua-13762	469	24	brca2	brca2	NOUN
aiua-13762	469	25	mutation	mutation	NOUN
aiua-13762	469	26	carriers	carrier	NOUN
aiua-13762	469	27	using	use	VERB
aiua-13762	469	28	polygenic	polygenic	ADJ
aiua-13762	469	29	risk	risk	NOUN
aiua-13762	469	30	scores	score	NOUN
aiua-13762	469	31	.	.	PUNCT
aiua-13762	470	1	j	j	PROPN
aiua-13762	470	2	clin	clin	PROPN
aiua-13762	470	3	oncol	oncol	PROPN
aiua-13762	470	4	2017	2017	NUM
aiua-13762	470	5	;	;	PUNCT
aiua-13762	470	6	35:2240	35:2240	NUM
aiua-13762	470	7	-	-	SYM
aiua-13762	470	8	2250	2250	NUM
aiua-13762	470	9	.	.	PUNCT
aiua-13762	471	1	51	51	NUM
aiua-13762	471	2	.	.	PUNCT
aiua-13762	471	3	kote	kote	VERB
aiua-13762	471	4	-	-	PUNCT
aiua-13762	471	5	jarai	jarai	PROPN
aiua-13762	471	6	z	z	NOUN
aiua-13762	471	7	,	,	PUNCT
aiua-13762	471	8	leongamornlert	leongamornlert	ADJ
aiua-13762	471	9	d	d	PROPN
aiua-13762	471	10	,	,	PUNCT
aiua-13762	471	11	saunders	saunders	PROPN
aiua-13762	471	12	e	e	PROPN
aiua-13762	471	13	,	,	PUNCT
aiua-13762	471	14	et	et	PROPN
aiua-13762	471	15	al	al	PROPN
aiua-13762	471	16	.	.	PUNCT
aiua-13762	471	17	brca2	brca2	PROPN
aiua-13762	471	18	is	be	AUX
aiua-13762	471	19	a	a	DET
aiua-13762	471	20	moderate	moderate	ADJ
aiua-13762	471	21	penetrance	penetrance	NOUN
aiua-13762	471	22	gene	gene	NOUN
aiua-13762	471	23	contributing	contribute	VERB
aiua-13762	471	24	to	to	ADP
aiua-13762	471	25	young	young	ADJ
aiua-13762	471	26	-	-	PUNCT
aiua-13762	471	27	onset	onset	VERB
aiua-13762	471	28	prostate	prostate	NOUN
aiua-13762	471	29	cancer	cancer	NOUN
aiua-13762	471	30	:	:	PUNCT
aiua-13762	471	31	implications	implication	NOUN
aiua-13762	471	32	for	for	ADP
aiua-13762	471	33	genetic	genetic	ADJ
aiua-13762	471	34	testing	testing	NOUN
aiua-13762	471	35	in	in	ADP
aiua-13762	471	36	prostate	prostate	NOUN
aiua-13762	471	37	cancer	cancer	NOUN
aiua-13762	471	38	patients	patient	NOUN
aiua-13762	471	39	.	.	PUNCT
aiua-13762	472	1	br	br	PROPN
aiua-13762	472	2	j	j	PROPN
aiua-13762	472	3	cancer	cancer	PROPN
aiua-13762	472	4	2011	2011	NUM
aiua-13762	472	5	;	;	PUNCT
aiua-13762	472	6	105:1230	105:1230	NUM
aiua-13762	472	7	-	-	SYM
aiua-13762	472	8	4	4	NUM
aiua-13762	472	9	.	.	NOUN
aiua-13762	472	10	52	52	NUM
aiua-13762	472	11	.	.	PUNCT
aiua-13762	473	1	roa	roa	PROPN
aiua-13762	473	2	bb	bb	PROPN
aiua-13762	473	3	,	,	PUNCT
aiua-13762	473	4	boyd	boyd	PROPN
aiua-13762	473	5	aa	aa	PROPN
aiua-13762	473	6	,	,	PUNCT
aiua-13762	473	7	volcik	volcik	PROPN
aiua-13762	473	8	k	k	PROPN
aiua-13762	473	9	,	,	PUNCT
aiua-13762	473	10	richards	richards	PROPN
aiua-13762	473	11	cs	cs	PROPN
aiua-13762	473	12	.	.	PROPN
aiua-13762	473	13	ashkenazi	ashkenazi	ADJ
aiua-13762	473	14	jewish	jewish	ADJ
aiua-13762	473	15	population	population	NOUN
aiua-13762	473	16	frequencies	frequency	NOUN
aiua-13762	473	17	for	for	ADP
aiua-13762	473	18	common	common	ADJ
aiua-13762	473	19	mutations	mutation	NOUN
aiua-13762	473	20	in	in	ADP
aiua-13762	473	21	brca1	brca1	PROPN
aiua-13762	473	22	and	and	CCONJ
aiua-13762	473	23	brca2	brca2	PROPN
aiua-13762	473	24	.	.	PUNCT
aiua-13762	474	1	nat	nat	PROPN
aiua-13762	474	2	genet	genet	PROPN
aiua-13762	474	3	1996	1996	NUM
aiua-13762	474	4	;	;	PUNCT
aiua-13762	474	5	14:185	14:185	NUM
aiua-13762	474	6	-	-	SYM
aiua-13762	474	7	7	7	NUM
aiua-13762	474	8	.	.	NUM
aiua-13762	474	9	53	53	NUM
aiua-13762	474	10	.	.	PUNCT
aiua-13762	474	11	bar	bar	NOUN
aiua-13762	474	12	-	-	PUNCT
aiua-13762	474	13	sade	sade	NOUN
aiua-13762	474	14	rb	rb	NOUN
aiua-13762	474	15	,	,	PUNCT
aiua-13762	474	16	kruglikova	kruglikova	X
aiua-13762	474	17	a	a	DET
aiua-13762	474	18	,	,	PUNCT
aiua-13762	474	19	modan	modan	PROPN
aiua-13762	474	20	b	b	PROPN
aiua-13762	474	21	,	,	PUNCT
aiua-13762	474	22	et	et	PROPN
aiua-13762	474	23	al	al	PROPN
aiua-13762	474	24	.	.	PUNCT
aiua-13762	475	1	the	the	DET
aiua-13762	475	2	185delag	185delag	PROPN
aiua-13762	475	3	brca1	brca1	PROPN
aiua-13762	475	4	mutation	mutation	NOUN
aiua-13762	475	5	originated	originate	VERB
aiua-13762	475	6	before	before	ADP
aiua-13762	475	7	the	the	DET
aiua-13762	475	8	dispersion	dispersion	NOUN
aiua-13762	475	9	of	of	ADP
aiua-13762	475	10	jews	jews	PROPN
aiua-13762	475	11	in	in	ADP
aiua-13762	475	12	the	the	DET
aiua-13762	475	13	diaspora	diaspora	NOUN
aiua-13762	475	14	and	and	CCONJ
aiua-13762	475	15	is	be	AUX
aiua-13762	475	16	not	not	PART
aiua-13762	475	17	limited	limit	VERB
aiua-13762	475	18	to	to	ADP
aiua-13762	475	19	ashkenazim	ashkenazim	PROPN
aiua-13762	475	20	.	.	PUNCT
aiua-13762	475	21	hum	hum	PROPN
aiua-13762	475	22	mol	mol	ADP
aiua-13762	475	23	genet	genet	PROPN
aiua-13762	475	24	1998	1998	NUM
aiua-13762	475	25	;	;	PUNCT
aiua-13762	475	26	7:8015	7:8015	NUM
aiua-13762	475	27	.	.	PUNCT
aiua-13762	476	1	54	54	NUM
aiua-13762	476	2	.	.	PUNCT
aiua-13762	477	1	mai	mai	PROPN
aiua-13762	477	2	pl	pl	PROPN
aiua-13762	477	3	,	,	PUNCT
aiua-13762	477	4	chatterjee	chatterjee	PROPN
aiua-13762	477	5	n	n	CCONJ
aiua-13762	477	6	,	,	PUNCT
aiua-13762	477	7	hartge	hartge	ADJ
aiua-13762	477	8	p	p	X
aiua-13762	477	9	,	,	PUNCT
aiua-13762	477	10	et	et	PROPN
aiua-13762	477	11	al	al	PROPN
aiua-13762	477	12	.	.	PROPN
aiua-13762	478	1	potential	potential	ADJ
aiua-13762	478	2	excess	excess	ADJ
aiua-13762	478	3	mortality	mortality	NOUN
aiua-13762	478	4	in	in	ADP
aiua-13762	478	5	brca1/2	brca1/2	ADJ
aiua-13762	478	6	mutation	mutation	NOUN
aiua-13762	478	7	carriers	carrier	NOUN
aiua-13762	478	8	beyond	beyond	ADP
aiua-13762	478	9	breast	breast	NOUN
aiua-13762	478	10	,	,	PUNCT
aiua-13762	478	11	ovarian	ovarian	ADJ
aiua-13762	478	12	,	,	PUNCT
aiua-13762	478	13	prostate	prostate	NOUN
aiua-13762	478	14	,	,	PUNCT
aiua-13762	478	15	and	and	CCONJ
aiua-13762	478	16	pancreatic	pancreatic	ADJ
aiua-13762	478	17	cancers	cancer	NOUN
aiua-13762	478	18	,	,	PUNCT
aiua-13762	478	19	and	and	CCONJ
aiua-13762	478	20	melanoma	melanoma	NOUN
aiua-13762	478	21	.	.	PUNCT
aiua-13762	479	1	plos	plos	PROPN
aiua-13762	479	2	one	one	NUM
aiua-13762	479	3	2009	2009	NUM
aiua-13762	479	4	;	;	PUNCT
aiua-13762	479	5	4	4	NUM
aiua-13762	479	6	:	:	PUNCT
aiua-13762	479	7	e4812	e4812	ADJ
aiua-13762	479	8	.	.	PUNCT
aiua-13762	479	9	55	55	NUM
aiua-13762	479	10	.	.	PUNCT
aiua-13762	480	1	theodor	theodor	PROPN
aiua-13762	480	2	l	l	NOUN
aiua-13762	480	3	,	,	PUNCT
aiua-13762	480	4	shiri	shiri	NOUN
aiua-13762	480	5	-	-	PUNCT
aiua-13762	480	6	sverdlov	sverdlov	PROPN
aiua-13762	480	7	r	r	NOUN
aiua-13762	480	8	,	,	PUNCT
aiua-13762	480	9	yechezkel	yechezkel	NOUN
aiua-13762	480	10	gh	gh	PROPN
aiua-13762	480	11	,	,	PUNCT
aiua-13762	480	12	et	et	PROPN
aiua-13762	480	13	al	al	PROPN
aiua-13762	480	14	.	.	PROPN
aiua-13762	480	15	experience	experience	PROPN
aiua-13762	480	16	at	at	ADP
aiua-13762	480	17	sheba	sheba	PROPN
aiua-13762	480	18	hospital	hospital	PROPN
aiua-13762	480	19	in	in	ADP
aiua-13762	480	20	oncogenetic	oncogenetic	ADJ
aiua-13762	480	21	counseling	counseling	NOUN
aiua-13762	480	22	and	and	CCONJ
aiua-13762	480	23	genetic	genetic	ADJ
aiua-13762	480	24	testing	testing	NOUN
aiua-13762	480	25	of	of	ADP
aiua-13762	480	26	women	woman	NOUN
aiua-13762	480	27	with	with	ADP
aiua-13762	480	28	a	a	DET
aiua-13762	480	29	high	high	ADJ
aiua-13762	480	30	risk	risk	NOUN
aiua-13762	480	31	for	for	ADP
aiua-13762	480	32	breast	breast	NOUN
aiua-13762	480	33	and	and	CCONJ
aiua-13762	480	34	ovarian	ovarian	ADJ
aiua-13762	480	35	cancer	cancer	NOUN
aiua-13762	480	36	.	.	PUNCT
aiua-13762	481	1	harefuah	harefuah	PROPN
aiua-13762	481	2	1998	1998	NUM
aiua-13762	481	3	;	;	PUNCT
aiua-13762	481	4	134:593	134:593	NUM
aiua-13762	481	5	-	-	SYM
aiua-13762	481	6	9	9	NUM
aiua-13762	481	7	.	.	NUM
aiua-13762	481	8	56	56	NUM
aiua-13762	481	9	.	.	PUNCT
aiua-13762	482	1	struewing	struewing	PROPN
aiua-13762	482	2	jp	jp	PROPN
aiua-13762	482	3	,	,	PUNCT
aiua-13762	482	4	hartge	hartge	PROPN
aiua-13762	482	5	p	p	X
aiua-13762	482	6	,	,	PUNCT
aiua-13762	482	7	wacholder	wacholder	NOUN
aiua-13762	482	8	s	s	PROPN
aiua-13762	482	9	,	,	PUNCT
aiua-13762	482	10	et	et	PROPN
aiua-13762	482	11	al	al	PROPN
aiua-13762	482	12	.	.	PUNCT
aiua-13762	483	1	the	the	DET
aiua-13762	483	2	risk	risk	NOUN
aiua-13762	483	3	of	of	ADP
aiua-13762	483	4	cancer	cancer	NOUN
aiua-13762	483	5	associated	associate	VERB
aiua-13762	483	6	with	with	ADP
aiua-13762	483	7	specific	specific	ADJ
aiua-13762	483	8	mutations	mutation	NOUN
aiua-13762	483	9	of	of	ADP
aiua-13762	483	10	brca1	brca1	PROPN
aiua-13762	483	11	and	and	CCONJ
aiua-13762	483	12	brca2	brca2	PROPN
aiua-13762	483	13	among	among	ADP
aiua-13762	483	14	ashkenazi	ashkenazi	ADJ
aiua-13762	483	15	jews	jews	PROPN
aiua-13762	483	16	.	.	PUNCT
aiua-13762	484	1	n	n	PROPN
aiua-13762	485	1	engl	engl	PROPN
aiua-13762	485	2	j	j	PROPN
aiua-13762	485	3	med	med	PROPN
aiua-13762	485	4	1997	1997	NUM
aiua-13762	485	5	;	;	PUNCT
aiua-13762	485	6	336:1401	336:1401	NUM
aiua-13762	485	7	-	-	SYM
aiua-13762	485	8	8	8	NUM
aiua-13762	485	9	.	.	PUNCT
aiua-13762	485	10	57	57	NUM
aiua-13762	485	11	.	.	PUNCT
aiua-13762	486	1	giusti	giusti	PROPN
aiua-13762	486	2	rm	rm	PROPN
aiua-13762	486	3	,	,	PUNCT
aiua-13762	486	4	rutter	rutter	PROPN
aiua-13762	486	5	jl	jl	PROPN
aiua-13762	486	6	,	,	PUNCT
aiua-13762	486	7	duray	duray	NOUN
aiua-13762	486	8	ph	ph	PROPN
aiua-13762	486	9	,	,	PUNCT
aiua-13762	486	10	et	et	PROPN
aiua-13762	486	11	al	al	PROPN
aiua-13762	486	12	.	.	PUNCT
aiua-13762	487	1	a	a	DET
aiua-13762	487	2	twofold	twofold	ADJ
aiua-13762	487	3	increase	increase	NOUN
aiua-13762	487	4	in	in	ADP
aiua-13762	487	5	brca	brca	PROPN
aiua-13762	487	6	mutation	mutation	NOUN
aiua-13762	487	7	-	-	PUNCT
aiua-13762	487	8	related	relate	VERB
aiua-13762	487	9	prostate	prostate	NOUN
aiua-13762	487	10	cancer	cancer	NOUN
aiua-13762	487	11	among	among	ADP
aiua-13762	487	12	ashkenazi	ashkenazi	ADJ
aiua-13762	487	13	israelis	israelis	PROPN
aiua-13762	487	14	is	be	AUX
aiua-13762	487	15	not	not	PART
aiua-13762	487	16	associated	associate	VERB
aiua-13762	487	17	with	with	ADP
aiua-13762	487	18	distinctive	distinctive	ADJ
aiua-13762	487	19	histopathology	histopathology	NOUN
aiua-13762	487	20	.	.	PUNCT
aiua-13762	488	1	j	j	PROPN
aiua-13762	488	2	med	med	PROPN
aiua-13762	488	3	genet	genet	PROPN
aiua-13762	488	4	2003	2003	NUM
aiua-13762	488	5	;	;	PUNCT
aiua-13762	488	6	40:787	40:787	NUM
aiua-13762	488	7	-	-	SYM
aiua-13762	488	8	92	92	NUM
aiua-13762	488	9	.	.	PUNCT
aiua-13762	489	1	58	58	NUM
aiua-13762	489	2	.	.	PUNCT
aiua-13762	490	1	vazina	vazina	VERB
aiua-13762	490	2	a	a	PRON
aiua-13762	490	3	,	,	PUNCT
aiua-13762	490	4	baniel	baniel	PROPN
aiua-13762	490	5	j	j	PROPN
aiua-13762	490	6	,	,	PUNCT
aiua-13762	490	7	yaacobi	yaacobi	PROPN
aiua-13762	490	8	y	y	PROPN
aiua-13762	490	9	,	,	PUNCT
aiua-13762	490	10	et	et	PROPN
aiua-13762	490	11	al	al	PROPN
aiua-13762	490	12	.	.	PUNCT
aiua-13762	491	1	the	the	DET
aiua-13762	491	2	rate	rate	NOUN
aiua-13762	491	3	of	of	ADP
aiua-13762	491	4	the	the	DET
aiua-13762	491	5	founder	founder	NOUN
aiua-13762	491	6	jewish	jewish	ADJ
aiua-13762	491	7	mutations	mutation	NOUN
aiua-13762	491	8	in	in	ADP
aiua-13762	491	9	brca1	brca1	PROPN
aiua-13762	491	10	and	and	CCONJ
aiua-13762	491	11	brca2	brca2	PROPN
aiua-13762	491	12	in	in	ADP
aiua-13762	491	13	prostate	prostate	NOUN
aiua-13762	491	14	cancer	cancer	NOUN
aiua-13762	491	15	patients	patient	NOUN
aiua-13762	491	16	in	in	ADP
aiua-13762	491	17	israel	israel	PROPN
aiua-13762	491	18	.	.	PUNCT
aiua-13762	492	1	br	br	PROPN
aiua-13762	492	2	j	j	PROPN
aiua-13762	492	3	cancer	cancer	PROPN
aiua-13762	492	4	2000	2000	NUM
aiua-13762	492	5	;	;	PUNCT
aiua-13762	492	6	83:463	83:463	NUM
aiua-13762	492	7	-	-	SYM
aiua-13762	492	8	6	6	NUM
aiua-13762	492	9	.	.	X
aiua-13762	492	10	59	59	NUM
aiua-13762	492	11	.	.	PUNCT
aiua-13762	493	1	sacks	sacks	PROPN
aiua-13762	493	2	h	h	PROPN
aiua-13762	493	3	,	,	PUNCT
aiua-13762	493	4	chalmers	chalmer	VERB
aiua-13762	493	5	tc	tc	PROPN
aiua-13762	493	6	,	,	PUNCT
aiua-13762	493	7	smith	smith	PROPN
aiua-13762	493	8	h	h	PROPN
aiua-13762	493	9	jr	jr	PROPN
aiua-13762	493	10	.	.	PROPN
aiua-13762	493	11	randomized	randomize	VERB
aiua-13762	493	12	versus	versus	ADP
aiua-13762	493	13	historical	historical	ADJ
aiua-13762	493	14	controls	control	NOUN
aiua-13762	493	15	for	for	ADP
aiua-13762	493	16	clinical	clinical	ADJ
aiua-13762	493	17	trials	trial	NOUN
aiua-13762	493	18	.	.	PUNCT
aiua-13762	494	1	am	be	AUX
aiua-13762	494	2	j	j	PROPN
aiua-13762	494	3	med	med	PROPN
aiua-13762	494	4	1982	1982	NUM
aiua-13762	494	5	;	;	PUNCT
aiua-13762	494	6	72:233	72:233	NUM
aiua-13762	494	7	-	-	SYM
aiua-13762	494	8	40	40	NUM
aiua-13762	494	9	.	.	PUNCT
aiua-13762	495	1	60	60	NUM
aiua-13762	495	2	.	.	PUNCT
aiua-13762	496	1	nickerson	nickerson	PROPN
aiua-13762	496	2	ml	ml	PROPN
aiua-13762	496	3	,	,	PUNCT
aiua-13762	496	4	i	i	PRON
aiua-13762	496	5	m	m	VERB
aiua-13762	496	6	km	km	NOUN
aiua-13762	496	7	,	,	PUNCT
aiua-13762	496	8	misner	misner	NOUN
aiua-13762	496	9	kj	kj	PROPN
aiua-13762	496	10	,	,	PUNCT
aiua-13762	496	11	et	et	PROPN
aiua-13762	496	12	al	al	PROPN
aiua-13762	496	13	.	.	PROPN
aiua-13762	496	14	somatic	somatic	ADJ
aiua-13762	496	15	alterations	alteration	NOUN
aiua-13762	496	16	contributing	contribute	VERB
aiua-13762	496	17	to	to	ADP
aiua-13762	496	18	metastasis	metastasis	NOUN
aiua-13762	496	19	of	of	ADP
aiua-13762	496	20	a	a	DET
aiua-13762	496	21	castration	castration	NOUN
aiua-13762	496	22	-	-	PUNCT
aiua-13762	496	23	resistant	resistant	ADJ
aiua-13762	496	24	prostate	prostate	NOUN
aiua-13762	496	25	cancer	cancer	NOUN
aiua-13762	496	26	.	.	PUNCT
aiua-13762	497	1	hum	hum	PROPN
aiua-13762	497	2	mutat	mutat	PROPN
aiua-13762	497	3	2013	2013	NUM
aiua-13762	497	4	;	;	PUNCT
aiua-13762	497	5	34:1231	34:1231	PROPN
aiua-13762	497	6	-	-	SYM
aiua-13762	497	7	41	41	NUM
aiua-13762	497	8	.	.	PUNCT
aiua-13762	497	9	61	61	NUM
aiua-13762	497	10	.	.	PUNCT
aiua-13762	498	1	patel	patel	PROPN
aiua-13762	498	2	vl	vl	PROPN
aiua-13762	498	3	,	,	PUNCT
aiua-13762	498	4	busch	busch	PROPN
aiua-13762	498	5	el	el	PROPN
aiua-13762	498	6	,	,	PUNCT
aiua-13762	498	7	friebel	friebel	PROPN
aiua-13762	498	8	tm	tm	PROPN
aiua-13762	498	9	,	,	PUNCT
aiua-13762	498	10	et	et	PROPN
aiua-13762	498	11	al	al	PROPN
aiua-13762	498	12	.	.	PROPN
aiua-13762	498	13	association	association	PROPN
aiua-13762	498	14	of	of	ADP
aiua-13762	498	15	genomic	genomic	NOUN
aiua-13762	498	16	domains	domain	NOUN
aiua-13762	498	17	in	in	ADP
aiua-13762	498	18	brca1	brca1	PROPN
aiua-13762	498	19	and	and	CCONJ
aiua-13762	498	20	brca2	brca2	PROPN
aiua-13762	498	21	with	with	ADP
aiua-13762	498	22	prostate	prostate	NOUN
aiua-13762	498	23	cancer	cancer	NOUN
aiua-13762	498	24	risk	risk	NOUN
aiua-13762	498	25	and	and	CCONJ
aiua-13762	498	26	aggressiveness	aggressiveness	NOUN
aiua-13762	498	27	.	.	PUNCT
aiua-13762	499	1	cancer	cancer	NOUN
aiua-13762	499	2	res	re	NOUN
aiua-13762	499	3	2020	2020	NUM
aiua-13762	499	4	;	;	PUNCT
aiua-13762	499	5	80:624	80:624	NUM
aiua-13762	499	6	-	-	PUNCT
aiua-13762	499	7	638	638	NUM
aiua-13762	499	8	.	.	PUNCT
aiua-13762	500	1	archivio	archivio	NOUN
aiua-13762	500	2	italiano	italiano	X
aiua-13762	500	3	di	di	PROPN
aiua-13762	500	4	urologia	urologia	PROPN
aiua-13762	500	5	e	e	PROPN
aiua-13762	500	6	andrologia	andrologia	NOUN
aiua-13762	500	7	2025	2025	NUM
aiua-13762	500	8	;	;	PUNCT
aiua-13762	500	9	97(2):13762	97(2):13762	NUM
aiua-13762	500	10	g.	g.	PROPN
aiua-13762	500	11	perletti	perletti	PROPN
aiua-13762	500	12	,	,	PUNCT
aiua-13762	500	13	d.	d.	PROPN
aiua-13762	500	14	cohen	cohen	PROPN
aiua-13762	500	15	hattab	hattab	PROPN
aiua-13762	500	16	,	,	PUNCT
aiua-13762	500	17	s.	s.	PROPN
aiua-13762	500	18	dellapergola	dellapergola	PROPN
aiua-13762	500	19	,	,	PUNCT
aiua-13762	500	20	et	et	PROPN
aiua-13762	500	21	al	al	PROPN
aiua-13762	500	22	.	.	PROPN
aiua-13762	500	23	12	12	NUM
aiua-13762	500	24	62	62	NUM
aiua-13762	500	25	.	.	PUNCT
aiua-13762	501	1	kirchhoff	kirchhoff	PROPN
aiua-13762	501	2	t	t	PROPN
aiua-13762	501	3	,	,	PUNCT
aiua-13762	501	4	kauff	kauff	PROPN
aiua-13762	501	5	nd	nd	PROPN
aiua-13762	501	6	,	,	PUNCT
aiua-13762	501	7	mitra	mitra	PROPN
aiua-13762	501	8	n	n	CCONJ
aiua-13762	501	9	,	,	PUNCT
aiua-13762	501	10	et	et	PROPN
aiua-13762	501	11	al	al	PROPN
aiua-13762	501	12	.	.	PUNCT
aiua-13762	501	13	brca	brca	PROPN
aiua-13762	501	14	mutations	mutation	NOUN
aiua-13762	501	15	and	and	CCONJ
aiua-13762	501	16	risk	risk	NOUN
aiua-13762	501	17	of	of	ADP
aiua-13762	501	18	prostate	prostate	NOUN
aiua-13762	501	19	cancer	cancer	NOUN
aiua-13762	501	20	in	in	ADP
aiua-13762	501	21	ashkenazi	ashkenazi	ADJ
aiua-13762	501	22	jews	jews	PROPN
aiua-13762	501	23	.	.	PUNCT
aiua-13762	502	1	clin	clin	PROPN
aiua-13762	502	2	cancer	cancer	NOUN
aiua-13762	502	3	res	re	NOUN
aiua-13762	502	4	2004	2004	NUM
aiua-13762	502	5	;	;	PUNCT
aiua-13762	502	6	10:2918	10:2918	NUM
aiua-13762	502	7	-	-	SYM
aiua-13762	502	8	21	21	NUM
aiua-13762	502	9	.	.	PUNCT
aiua-13762	503	1	63	63	NUM
aiua-13762	503	2	.	.	PUNCT
aiua-13762	504	1	gallagher	gallagher	PROPN
aiua-13762	504	2	dj	dj	PROPN
aiua-13762	504	3	,	,	PUNCT
aiua-13762	504	4	gaudet	gaudet	PROPN
aiua-13762	504	5	mm	mm	PROPN
aiua-13762	504	6	,	,	PUNCT
aiua-13762	504	7	pal	pal	NOUN
aiua-13762	504	8	p	p	NOUN
aiua-13762	504	9	,	,	PUNCT
aiua-13762	504	10	et	et	PROPN
aiua-13762	504	11	al	al	PROPN
aiua-13762	504	12	.	.	PROPN
aiua-13762	504	13	germline	germline	PROPN
aiua-13762	504	14	brca	brca	PROPN
aiua-13762	504	15	mutations	mutation	NOUN
aiua-13762	504	16	denote	denote	VERB
aiua-13762	504	17	a	a	DET
aiua-13762	504	18	clinicopathologic	clinicopathologic	ADJ
aiua-13762	504	19	subset	subset	NOUN
aiua-13762	504	20	of	of	ADP
aiua-13762	504	21	prostate	prostate	NOUN
aiua-13762	504	22	cancer	cancer	NOUN
aiua-13762	504	23	.	.	PUNCT
aiua-13762	505	1	clin	clin	PROPN
aiua-13762	505	2	cancer	cancer	NOUN
aiua-13762	505	3	res	re	NOUN
aiua-13762	505	4	2010	2010	NUM
aiua-13762	505	5	;	;	PUNCT
aiua-13762	505	6	16:2115	16:2115	NUM
aiua-13762	505	7	-	-	SYM
aiua-13762	505	8	21	21	NUM
aiua-13762	505	9	.	.	PUNCT
aiua-13762	506	1	64	64	NUM
aiua-13762	506	2	.	.	PUNCT
aiua-13762	506	3	agalliu	agalliu	VERB
aiua-13762	506	4	i	i	PRON
aiua-13762	506	5	,	,	PUNCT
aiua-13762	506	6	gern	gern	ADJ
aiua-13762	506	7	r	r	NOUN
aiua-13762	506	8	,	,	PUNCT
aiua-13762	506	9	leanza	leanza	NOUN
aiua-13762	506	10	s	s	PROPN
aiua-13762	506	11	,	,	PUNCT
aiua-13762	506	12	burk	burk	PROPN
aiua-13762	506	13	rd	rd	PROPN
aiua-13762	506	14	.	.	PUNCT
aiua-13762	507	1	associations	association	NOUN
aiua-13762	507	2	of	of	ADP
aiua-13762	507	3	high	high	ADJ
aiua-13762	507	4	-	-	PUNCT
aiua-13762	507	5	grade	grade	NOUN
aiua-13762	507	6	prostate	prostate	NOUN
aiua-13762	507	7	cancer	cancer	NOUN
aiua-13762	507	8	with	with	ADP
aiua-13762	507	9	brca1	brca1	PROPN
aiua-13762	507	10	and	and	CCONJ
aiua-13762	507	11	brca2	brca2	PROPN
aiua-13762	507	12	founder	founder	NOUN
aiua-13762	507	13	mutations	mutation	NOUN
aiua-13762	507	14	.	.	PUNCT
aiua-13762	508	1	clin	clin	PROPN
aiua-13762	508	2	cancer	cancer	NOUN
aiua-13762	508	3	res	re	NOUN
aiua-13762	508	4	2009	2009	NUM
aiua-13762	508	5	;	;	PUNCT
aiua-13762	508	6	15:1112	15:1112	NUM
aiua-13762	508	7	-	-	SYM
aiua-13762	508	8	20	20	NUM
aiua-13762	508	9	.	.	PUNCT
aiua-13762	508	10	65	65	NUM
aiua-13762	508	11	.	.	PUNCT
aiua-13762	509	1	hamel	hamel	PROPN
aiua-13762	509	2	n	n	PROPN
aiua-13762	509	3	,	,	PUNCT
aiua-13762	509	4	kotar	kotar	PROPN
aiua-13762	509	5	k	k	PROPN
aiua-13762	509	6	,	,	PUNCT
aiua-13762	509	7	foulkes	foulkes	PROPN
aiua-13762	509	8	wd	wd	PROPN
aiua-13762	509	9	.	.	PROPN
aiua-13762	509	10	founder	founder	NOUN
aiua-13762	509	11	mutations	mutation	NOUN
aiua-13762	509	12	in	in	ADP
aiua-13762	509	13	brca1/2	brca1/2	PROPN
aiua-13762	509	14	are	be	AUX
aiua-13762	509	15	not	not	PART
aiua-13762	509	16	frequent	frequent	ADJ
aiua-13762	509	17	in	in	ADP
aiua-13762	509	18	canadian	canadian	ADJ
aiua-13762	509	19	ashkenazi	ashkenazi	ADJ
aiua-13762	509	20	jewish	jewish	ADJ
aiua-13762	509	21	men	man	NOUN
aiua-13762	509	22	with	with	ADP
aiua-13762	509	23	prostate	prostate	NOUN
aiua-13762	509	24	cancer	cancer	NOUN
aiua-13762	509	25	.	.	PUNCT
aiua-13762	510	1	bmc	bmc	PROPN
aiua-13762	510	2	med	med	PROPN
aiua-13762	510	3	genet	genet	PROPN
aiua-13762	510	4	2003	2003	NUM
aiua-13762	510	5	;	;	PUNCT
aiua-13762	510	6	4:7	4:7	NUM
aiua-13762	510	7	.	.	PUNCT
aiua-13762	511	1	66	66	NUM
aiua-13762	511	2	.	.	PUNCT
aiua-13762	512	1	hubert	hubert	PROPN
aiua-13762	512	2	a	a	PRON
aiua-13762	512	3	,	,	PUNCT
aiua-13762	512	4	peretz	peretz	PROPN
aiua-13762	512	5	t	t	PROPN
aiua-13762	512	6	,	,	PUNCT
aiua-13762	512	7	manor	manor	NOUN
aiua-13762	512	8	o	o	PROPN
aiua-13762	512	9	,	,	PUNCT
aiua-13762	512	10	et	et	PROPN
aiua-13762	512	11	al	al	PROPN
aiua-13762	512	12	.	.	PUNCT
aiua-13762	513	1	the	the	DET
aiua-13762	513	2	jewish	jewish	ADJ
aiua-13762	513	3	ashkenazi	ashkenazi	PROPN
aiua-13762	513	4	founder	founder	NOUN
aiua-13762	513	5	mutations	mutation	NOUN
aiua-13762	513	6	in	in	ADP
aiua-13762	513	7	the	the	DET
aiua-13762	513	8	brca1	brca1	PROPN
aiua-13762	513	9	/	/	SYM
aiua-13762	513	10	brca2	brca2	NOUN
aiua-13762	513	11	genes	gene	NOUN
aiua-13762	513	12	are	be	AUX
aiua-13762	513	13	not	not	PART
aiua-13762	513	14	found	find	VERB
aiua-13762	513	15	at	at	ADP
aiua-13762	513	16	an	an	DET
aiua-13762	513	17	increased	increase	VERB
aiua-13762	513	18	frequency	frequency	NOUN
aiua-13762	513	19	in	in	ADP
aiua-13762	513	20	ashkenazi	ashkenazi	ADJ
aiua-13762	513	21	patients	patient	NOUN
aiua-13762	513	22	with	with	ADP
aiua-13762	513	23	prostate	prostate	NOUN
aiua-13762	513	24	cancer	cancer	NOUN
aiua-13762	513	25	.	.	PUNCT
aiua-13762	514	1	am	be	AUX
aiua-13762	514	2	j	j	PROPN
aiua-13762	514	3	hum	hum	PROPN
aiua-13762	514	4	genet	genet	PROPN
aiua-13762	514	5	1999	1999	NUM
aiua-13762	514	6	;	;	PUNCT
aiua-13762	514	7	65:921	65:921	X
aiua-13762	514	8	-	-	SYM
aiua-13762	514	9	4	4	NUM
aiua-13762	514	10	.	.	NUM
aiua-13762	514	11	67	67	NUM
aiua-13762	514	12	.	.	PUNCT
aiua-13762	515	1	kwon	kwon	PROPN
aiua-13762	515	2	dh	dh	PROPN
aiua-13762	515	3	,	,	PUNCT
aiua-13762	515	4	borno	borno	PROPN
aiua-13762	515	5	ht	ht	PROPN
aiua-13762	515	6	,	,	PUNCT
aiua-13762	515	7	cheng	cheng	PROPN
aiua-13762	515	8	hh	hh	PROPN
aiua-13762	515	9	,	,	PUNCT
aiua-13762	515	10	et	et	PROPN
aiua-13762	515	11	al	al	PROPN
aiua-13762	515	12	.	.	PUNCT
aiua-13762	516	1	ethnic	ethnic	ADJ
aiua-13762	516	2	disparities	disparity	NOUN
aiua-13762	516	3	among	among	ADP
aiua-13762	516	4	men	man	NOUN
aiua-13762	516	5	with	with	ADP
aiua-13762	516	6	prostate	prostate	NOUN
aiua-13762	516	7	cancer	cancer	NOUN
aiua-13762	516	8	undergoing	undergo	VERB
aiua-13762	516	9	germline	germline	NOUN
aiua-13762	516	10	testing	testing	NOUN
aiua-13762	516	11	.	.	PUNCT
aiua-13762	517	1	urol	urol	ADJ
aiua-13762	517	2	oncol	oncol	ADJ
aiua-13762	517	3	2020	2020	NUM
aiua-13762	517	4	;	;	PUNCT
aiua-13762	517	5	38:80.e1	38:80.e1	X
aiua-13762	517	6	-	-	PUNCT
aiua-13762	517	7	80.e7	80.e7	NUM
aiua-13762	517	8	.	.	PROPN
aiua-13762	517	9	68	68	NUM
aiua-13762	517	10	.	.	PUNCT
aiua-13762	518	1	lehrer	lehrer	PROPN
aiua-13762	518	2	s	s	PROPN
aiua-13762	518	3	,	,	PUNCT
aiua-13762	518	4	fodor	fodor	PROPN
aiua-13762	518	5	f	f	PROPN
aiua-13762	518	6	,	,	PUNCT
aiua-13762	518	7	stock	stock	PROPN
aiua-13762	518	8	rg	rg	PROPN
aiua-13762	518	9	,	,	PUNCT
aiua-13762	518	10	et	et	PROPN
aiua-13762	518	11	al	al	PROPN
aiua-13762	518	12	.	.	PROPN
aiua-13762	518	13	absence	absence	NOUN
aiua-13762	518	14	of	of	ADP
aiua-13762	518	15	185delag	185delag	PROPN
aiua-13762	518	16	mutation	mutation	NOUN
aiua-13762	518	17	of	of	ADP
aiua-13762	518	18	the	the	DET
aiua-13762	518	19	brca1	brca1	PROPN
aiua-13762	518	20	gene	gene	NOUN
aiua-13762	518	21	and	and	CCONJ
aiua-13762	518	22	6174delt	6174delt	NUM
aiua-13762	518	23	mutation	mutation	NOUN
aiua-13762	518	24	of	of	ADP
aiua-13762	518	25	the	the	DET
aiua-13762	518	26	brca2	brca2	NOUN
aiua-13762	518	27	gene	gene	NOUN
aiua-13762	518	28	in	in	ADP
aiua-13762	518	29	ashkenazi	ashkenazi	ADJ
aiua-13762	518	30	jewish	jewish	ADJ
aiua-13762	518	31	men	man	NOUN
aiua-13762	518	32	with	with	ADP
aiua-13762	518	33	prostate	prostate	NOUN
aiua-13762	518	34	cancer	cancer	NOUN
aiua-13762	518	35	.	.	PUNCT
aiua-13762	519	1	br	br	PROPN
aiua-13762	519	2	j	j	PROPN
aiua-13762	519	3	cancer	cancer	NOUN
aiua-13762	519	4	1998	1998	NUM
aiua-13762	519	5	;	;	PUNCT
aiua-13762	519	6	78:771	78:771	NUM
aiua-13762	519	7	-	-	SYM
aiua-13762	519	8	3	3	NUM
aiua-13762	519	9	.	.	NUM
aiua-13762	519	10	69	69	NUM
aiua-13762	519	11	.	.	PUNCT
aiua-13762	520	1	wilkens	wilkens	PROPN
aiua-13762	520	2	ep	ep	PROPN
aiua-13762	520	3	,	,	PUNCT
aiua-13762	520	4	freije	freije	NOUN
aiua-13762	520	5	d	d	NOUN
aiua-13762	520	6	,	,	PUNCT
aiua-13762	520	7	nusskern	nusskern	PROPN
aiua-13762	520	8	dr	dr	PROPN
aiua-13762	520	9	,	,	PUNCT
aiua-13762	520	10	et	et	PROPN
aiua-13762	520	11	al	al	PROPN
aiua-13762	520	12	.	.	PUNCT
aiua-13762	521	1	no	no	DET
aiua-13762	521	2	evidence	evidence	NOUN
aiua-13762	521	3	for	for	ADP
aiua-13762	521	4	a	a	DET
aiua-13762	521	5	role	role	NOUN
aiua-13762	521	6	of	of	ADP
aiua-13762	521	7	brca1	brca1	PROPN
aiua-13762	521	8	or	or	CCONJ
aiua-13762	521	9	brca2	brca2	NOUN
aiua-13762	521	10	mutations	mutation	NOUN
aiua-13762	521	11	in	in	ADP
aiua-13762	521	12	ashkenazi	ashkenazi	ADJ
aiua-13762	521	13	jewish	jewish	ADJ
aiua-13762	521	14	families	family	NOUN
aiua-13762	521	15	with	with	ADP
aiua-13762	521	16	hereditary	hereditary	ADJ
aiua-13762	521	17	prostate	prostate	NOUN
aiua-13762	521	18	cancer	cancer	NOUN
aiua-13762	521	19	.	.	PUNCT
aiua-13762	522	1	prostate	prostate	NOUN
aiua-13762	522	2	1999	1999	NUM
aiua-13762	522	3	;	;	PUNCT
aiua-13762	522	4	39:280	39:280	NUM
aiua-13762	522	5	-	-	SYM
aiua-13762	522	6	4	4	NUM
aiua-13762	522	7	.	.	NOUN
aiua-13762	522	8	70	70	NUM
aiua-13762	522	9	.	.	PUNCT
aiua-13762	523	1	friedman	friedman	PROPN
aiua-13762	523	2	ls	ls	PROPN
aiua-13762	523	3	,	,	PUNCT
aiua-13762	523	4	szabo	szabo	PROPN
aiua-13762	523	5	ci	ci	PROPN
aiua-13762	523	6	,	,	PUNCT
aiua-13762	523	7	ostermeyer	ostermeyer	NOUN
aiua-13762	523	8	ea	ea	PROPN
aiua-13762	523	9	,	,	PUNCT
aiua-13762	523	10	et	et	PROPN
aiua-13762	523	11	al	al	PROPN
aiua-13762	523	12	.	.	PROPN
aiua-13762	523	13	novel	novel	PROPN
aiua-13762	523	14	inherited	inherit	VERB
aiua-13762	523	15	mutations	mutation	NOUN
aiua-13762	523	16	and	and	CCONJ
aiua-13762	523	17	variable	variable	ADJ
aiua-13762	523	18	expressivity	expressivity	NOUN
aiua-13762	523	19	of	of	ADP
aiua-13762	523	20	brca1	brca1	PROPN
aiua-13762	523	21	alleles	allele	NOUN
aiua-13762	523	22	,	,	PUNCT
aiua-13762	523	23	including	include	VERB
aiua-13762	523	24	the	the	DET
aiua-13762	523	25	founder	founder	NOUN
aiua-13762	523	26	mutation	mutation	NOUN
aiua-13762	523	27	185delag	185delag	PROPN
aiua-13762	523	28	in	in	ADP
aiua-13762	523	29	ashkenazi	ashkenazi	ADJ
aiua-13762	523	30	jewish	jewish	ADJ
aiua-13762	523	31	families	family	NOUN
aiua-13762	523	32	.	.	PUNCT
aiua-13762	523	33	am	be	AUX
aiua-13762	523	34	j	j	PROPN
aiua-13762	523	35	hum	hum	PROPN
aiua-13762	523	36	genet	genet	PROPN
aiua-13762	523	37	1995	1995	NUM
aiua-13762	523	38	;	;	PUNCT
aiua-13762	523	39	57:1284	57:1284	NUM
aiua-13762	523	40	-	-	SYM
aiua-13762	523	41	97	97	NUM
aiua-13762	523	42	.	.	PUNCT
aiua-13762	524	1	71	71	NUM
aiua-13762	524	2	.	.	X
aiua-13762	524	3	nastiuk	nastiuk	PROPN
aiua-13762	524	4	kl	kl	PROPN
aiua-13762	524	5	,	,	PUNCT
aiua-13762	524	6	mansukhani	mansukhani	PROPN
aiua-13762	524	7	m	m	PROPN
aiua-13762	524	8	,	,	PUNCT
aiua-13762	524	9	terry	terry	PROPN
aiua-13762	524	10	mb	mb	PROPN
aiua-13762	524	11	,	,	PUNCT
aiua-13762	524	12	et	et	PROPN
aiua-13762	524	13	al	al	PROPN
aiua-13762	524	14	.	.	PUNCT
aiua-13762	524	15	common	common	ADJ
aiua-13762	524	16	mutations	mutation	NOUN
aiua-13762	524	17	in	in	ADP
aiua-13762	524	18	brca1	brca1	PROPN
aiua-13762	524	19	and	and	CCONJ
aiua-13762	524	20	brca2	brca2	PROPN
aiua-13762	524	21	do	do	AUX
aiua-13762	524	22	not	not	PART
aiua-13762	524	23	contribute	contribute	VERB
aiua-13762	524	24	to	to	ADP
aiua-13762	524	25	early	early	ADJ
aiua-13762	524	26	prostate	prostate	NOUN
aiua-13762	524	27	cancer	cancer	NOUN
aiua-13762	524	28	in	in	ADP
aiua-13762	524	29	jewish	jewish	ADJ
aiua-13762	524	30	men	man	NOUN
aiua-13762	524	31	.	.	PUNCT
aiua-13762	525	1	prostate	prostate	NOUN
aiua-13762	525	2	1999	1999	NUM
aiua-13762	525	3	;	;	PUNCT
aiua-13762	525	4	40:172	40:172	NUM
aiua-13762	525	5	-	-	SYM
aiua-13762	525	6	177	177	NUM
aiua-13762	525	7	.	.	PUNCT
aiua-13762	525	8	72	72	NUM
aiua-13762	525	9	.	.	PUNCT
aiua-13762	526	1	oh	oh	NUM
aiua-13762	526	2	m	m	PROPN
aiua-13762	526	3	,	,	PUNCT
aiua-13762	526	4	alkhushaym	alkhushaym	PROPN
aiua-13762	526	5	n	n	CCONJ
aiua-13762	526	6	,	,	PUNCT
aiua-13762	526	7	fallatah	fallatah	PROPN
aiua-13762	526	8	s	s	PROPN
aiua-13762	526	9	,	,	PUNCT
aiua-13762	526	10	et	et	PROPN
aiua-13762	526	11	al	al	PROPN
aiua-13762	526	12	.	.	PUNCT
aiua-13762	527	1	the	the	DET
aiua-13762	527	2	association	association	PROPN
aiua-13762	527	3	of	of	ADP
aiua-13762	527	4	brca1	brca1	PROPN
aiua-13762	527	5	and	and	CCONJ
aiua-13762	527	6	brca2	brca2	NOUN
aiua-13762	527	7	mutations	mutation	NOUN
aiua-13762	527	8	with	with	ADP
aiua-13762	527	9	prostate	prostate	NOUN
aiua-13762	527	10	cancer	cancer	NOUN
aiua-13762	527	11	risk	risk	NOUN
aiua-13762	527	12	,	,	PUNCT
aiua-13762	527	13	frequency	frequency	NOUN
aiua-13762	527	14	,	,	PUNCT
aiua-13762	527	15	and	and	CCONJ
aiua-13762	527	16	mortality	mortality	NOUN
aiua-13762	527	17	:	:	PUNCT
aiua-13762	527	18	a	a	DET
aiua-13762	527	19	meta	meta	ADJ
aiua-13762	527	20	-	-	PUNCT
aiua-13762	527	21	analysis	analysis	NOUN
aiua-13762	527	22	.	.	PUNCT
aiua-13762	528	1	prostate	prostate	NOUN
aiua-13762	528	2	2019	2019	NUM
aiua-13762	528	3	;	;	PUNCT
aiua-13762	528	4	79:880	79:880	NUM
aiua-13762	528	5	-	-	SYM
aiua-13762	528	6	895	895	NUM
aiua-13762	528	7	.	.	PUNCT
aiua-13762	528	8	73	73	NUM
aiua-13762	528	9	.	.	PUNCT
aiua-13762	529	1	nyberg	nyberg	PROPN
aiua-13762	529	2	t	t	PROPN
aiua-13762	529	3	,	,	PUNCT
aiua-13762	529	4	tischkowitz	tischkowitz	NOUN
aiua-13762	529	5	m	m	PROPN
aiua-13762	529	6	,	,	PUNCT
aiua-13762	529	7	antoniou	antoniou	PROPN
aiua-13762	529	8	ac	ac	PROPN
aiua-13762	529	9	.	.	PUNCT
aiua-13762	530	1	brca1	brca1	PROPN
aiua-13762	530	2	and	and	CCONJ
aiua-13762	530	3	brca2	brca2	NOUN
aiua-13762	530	4	pathogenic	pathogenic	ADJ
aiua-13762	530	5	variants	variant	NOUN
aiua-13762	530	6	and	and	CCONJ
aiua-13762	530	7	prostate	prostate	NOUN
aiua-13762	530	8	cancer	cancer	NOUN
aiua-13762	530	9	risk	risk	NOUN
aiua-13762	530	10	:	:	PUNCT
aiua-13762	530	11	systematic	systematic	ADJ
aiua-13762	530	12	review	review	NOUN
aiua-13762	530	13	and	and	CCONJ
aiua-13762	530	14	meta	meta	ADJ
aiua-13762	530	15	-	-	PUNCT
aiua-13762	530	16	analysis	analysis	NOUN
aiua-13762	530	17	.	.	PUNCT
aiua-13762	531	1	br	br	PROPN
aiua-13762	531	2	j	j	PROPN
aiua-13762	531	3	cancer	cancer	NOUN
aiua-13762	531	4	2022	2022	NUM
aiua-13762	531	5	;	;	PUNCT
aiua-13762	531	6	126:1067	126:1067	NUM
aiua-13762	531	7	-	-	SYM
aiua-13762	531	8	1081	1081	NUM
aiua-13762	531	9	74	74	NUM
aiua-13762	531	10	.	.	PUNCT
aiua-13762	532	1	cioffi	cioffi	VERB
aiua-13762	532	2	a	a	PRON
aiua-13762	532	3	,	,	PUNCT
aiua-13762	532	4	de	de	X
aiua-13762	532	5	cobelli	cobelli	PROPN
aiua-13762	532	6	o	o	NOUN
aiua-13762	532	7	,	,	PUNCT
aiua-13762	532	8	veronesi	veronesi	NOUN
aiua-13762	532	9	p	p	X
aiua-13762	532	10	,	,	PUNCT
aiua-13762	532	11	et	et	PROPN
aiua-13762	532	12	al	al	PROPN
aiua-13762	532	13	.	.	PUNCT
aiua-13762	533	1	prevalence	prevalence	NOUN
aiua-13762	533	2	of	of	ADP
aiua-13762	533	3	germline	germline	PROPN
aiua-13762	533	4	brca1/2	brca1/2	PROPN
aiua-13762	533	5	variants	variant	NOUN
aiua-13762	533	6	in	in	ADP
aiua-13762	533	7	ashkenazi	ashkenazi	ADJ
aiua-13762	533	8	and	and	CCONJ
aiua-13762	533	9	non	non	ADJ
aiua-13762	533	10	-	-	ADJ
aiua-13762	533	11	ashkenazi	ashkenazi	ADJ
aiua-13762	533	12	prostate	prostate	NOUN
aiua-13762	533	13	cancer	cancer	NOUN
aiua-13762	533	14	populations	population	NOUN
aiua-13762	533	15	:	:	PUNCT
aiua-13762	533	16	a	a	DET
aiua-13762	533	17	systematic	systematic	ADJ
aiua-13762	533	18	review	review	NOUN
aiua-13762	533	19	and	and	CCONJ
aiua-13762	533	20	meta	meta	ADJ
aiua-13762	533	21	-	-	PUNCT
aiua-13762	533	22	analysis	analysis	NOUN
aiua-13762	533	23	.	.	PUNCT
aiua-13762	534	1	cancers	cancer	NOUN
aiua-13762	534	2	(	(	PUNCT
aiua-13762	534	3	basel	basel	PROPN
aiua-13762	534	4	)	)	PUNCT
aiua-13762	534	5	2023	2023	NUM
aiua-13762	534	6	;	;	PUNCT
aiua-13762	534	7	15:306	15:306	NUM
aiua-13762	534	8	.	.	PUNCT
aiua-13762	535	1	75	75	NUM
aiua-13762	535	2	.	.	PUNCT
aiua-13762	536	1	brewster	brewster	PROPN
aiua-13762	536	2	sf	sf	PROPN
aiua-13762	536	3	,	,	PUNCT
aiua-13762	536	4	browne	browne	PROPN
aiua-13762	536	5	s	s	PROPN
aiua-13762	536	6	,	,	PUNCT
aiua-13762	536	7	brown	brown	ADJ
aiua-13762	536	8	kw	kw	NOUN
aiua-13762	536	9	.	.	PUNCT
aiua-13762	536	10	somatic	somatic	ADJ
aiua-13762	536	11	allelic	allelic	ADJ
aiua-13762	536	12	loss	loss	NOUN
aiua-13762	536	13	at	at	ADP
aiua-13762	536	14	the	the	DET
aiua-13762	536	15	dcc	dcc	PROPN
aiua-13762	536	16	,	,	PUNCT
aiua-13762	536	17	apc	apc	PROPN
aiua-13762	536	18	,	,	PUNCT
aiua-13762	536	19	nm23	nm23	PROPN
aiua-13762	536	20	-	-	PUNCT
aiua-13762	536	21	h1	h1	PROPN
aiua-13762	536	22	and	and	CCONJ
aiua-13762	536	23	p53	p53	NOUN
aiua-13762	536	24	tumor	tumor	NOUN
aiua-13762	536	25	suppressor	suppressor	NOUN
aiua-13762	536	26	gene	gene	NOUN
aiua-13762	536	27	loci	locus	NOUN
aiua-13762	536	28	in	in	ADP
aiua-13762	536	29	human	human	ADJ
aiua-13762	536	30	prostatic	prostatic	ADJ
aiua-13762	536	31	carcinoma	carcinoma	NOUN
aiua-13762	536	32	.	.	PUNCT
aiua-13762	537	1	j	j	PROPN
aiua-13762	537	2	urol	urol	PROPN
aiua-13762	537	3	1994	1994	NUM
aiua-13762	537	4	;	;	PUNCT
aiua-13762	537	5	151:1073	151:1073	NUM
aiua-13762	537	6	-	-	SYM
aiua-13762	537	7	7	7	NUM
aiua-13762	537	8	.	.	NUM
aiua-13762	537	9	76	76	NUM
aiua-13762	537	10	.	.	PUNCT
aiua-13762	538	1	phillips	phillips	PROPN
aiua-13762	538	2	sm	sm	PROPN
aiua-13762	538	3	,	,	PUNCT
aiua-13762	538	4	morton	morton	PROPN
aiua-13762	538	5	dg	dg	PROPN
aiua-13762	538	6	,	,	PUNCT
aiua-13762	538	7	lee	lee	PROPN
aiua-13762	538	8	sj	sj	PROPN
aiua-13762	538	9	,	,	PUNCT
aiua-13762	538	10	et	et	PROPN
aiua-13762	538	11	al	al	PROPN
aiua-13762	538	12	.	.	PUNCT
aiua-13762	538	13	loss	loss	NOUN
aiua-13762	538	14	of	of	ADP
aiua-13762	538	15	heterozygosity	heterozygosity	NOUN
aiua-13762	538	16	of	of	ADP
aiua-13762	538	17	the	the	DET
aiua-13762	538	18	retinoblastoma	retinoblastoma	NOUN
aiua-13762	538	19	and	and	CCONJ
aiua-13762	538	20	adenomatous	adenomatous	ADJ
aiua-13762	538	21	polyposis	polyposis	NOUN
aiua-13762	538	22	susceptibility	susceptibility	NOUN
aiua-13762	538	23	gene	gene	NOUN
aiua-13762	538	24	loci	locus	NOUN
aiua-13762	538	25	and	and	CCONJ
aiua-13762	538	26	in	in	ADP
aiua-13762	538	27	chromosomes	chromosome	NOUN
aiua-13762	538	28	10p	10p	NOUN
aiua-13762	538	29	,	,	PUNCT
aiua-13762	538	30	10q	10q	NOUN
aiua-13762	538	31	and	and	CCONJ
aiua-13762	538	32	16q	16q	NOUN
aiua-13762	538	33	in	in	ADP
aiua-13762	538	34	human	human	ADJ
aiua-13762	538	35	prostate	prostate	NOUN
aiua-13762	538	36	cancer	cancer	NOUN
aiua-13762	538	37	.	.	PUNCT
aiua-13762	539	1	br	br	PROPN
aiua-13762	540	1	j	j	PROPN
aiua-13762	540	2	urol	urol	PROPN
aiua-13762	540	3	1994	1994	NUM
aiua-13762	540	4	;	;	PUNCT
aiua-13762	540	5	73:390	73:390	NOUN
aiua-13762	540	6	-	-	SYM
aiua-13762	540	7	5	5	NUM
aiua-13762	540	8	.	.	NOUN
aiua-13762	540	9	77	77	NUM
aiua-13762	540	10	.	.	PUNCT
aiua-13762	541	1	laken	laken	PROPN
aiua-13762	541	2	sj	sj	PROPN
aiua-13762	541	3	,	,	PUNCT
aiua-13762	541	4	petersen	petersen	PROPN
aiua-13762	541	5	gm	gm	PROPN
aiua-13762	541	6	,	,	PUNCT
aiua-13762	541	7	gruber	gruber	PROPN
aiua-13762	541	8	sb	sb	PROPN
aiua-13762	541	9	,	,	PUNCT
aiua-13762	541	10	et	et	PROPN
aiua-13762	541	11	al	al	PROPN
aiua-13762	541	12	.	.	PUNCT
aiua-13762	542	1	familial	familial	ADJ
aiua-13762	542	2	colorectal	colorectal	ADJ
aiua-13762	542	3	cancer	cancer	NOUN
aiua-13762	542	4	in	in	ADP
aiua-13762	542	5	ashkenazim	ashkenazim	PROPN
aiua-13762	542	6	due	due	ADP
aiua-13762	542	7	to	to	ADP
aiua-13762	542	8	a	a	DET
aiua-13762	542	9	hypermutable	hypermutable	ADJ
aiua-13762	542	10	tract	tract	NOUN
aiua-13762	542	11	in	in	ADP
aiua-13762	542	12	apc	apc	PROPN
aiua-13762	542	13	.	.	PUNCT
aiua-13762	543	1	nat	nat	PROPN
aiua-13762	543	2	genet	genet	PROPN
aiua-13762	543	3	1997	1997	NUM
aiua-13762	543	4	;	;	PUNCT
aiua-13762	543	5	17:79	17:79	NUM
aiua-13762	543	6	-	-	SYM
aiua-13762	543	7	83	83	NUM
aiua-13762	543	8	.	.	PUNCT
aiua-13762	544	1	78	78	NUM
aiua-13762	544	2	.	.	PUNCT
aiua-13762	545	1	boursi	boursi	PROPN
aiua-13762	545	2	b	b	PROPN
aiua-13762	545	3	,	,	PUNCT
aiua-13762	545	4	sella	sella	NOUN
aiua-13762	545	5	t	t	PROPN
aiua-13762	545	6	,	,	PUNCT
aiua-13762	545	7	liberman	liberman	PROPN
aiua-13762	545	8	e	e	PROPN
aiua-13762	545	9	,	,	PUNCT
aiua-13762	545	10	shapira	shapira	PROPN
aiua-13762	545	11	s	s	PROPN
aiua-13762	545	12	,	,	PUNCT
aiua-13762	545	13	et	et	PROPN
aiua-13762	545	14	al	al	PROPN
aiua-13762	545	15	.	.	PUNCT
aiua-13762	546	1	the	the	DET
aiua-13762	546	2	apc	apc	PROPN
aiua-13762	546	3	p.i1307k	p.i1307k	PROPN
aiua-13762	546	4	polymorphism	polymorphism	NOUN
aiua-13762	546	5	is	be	AUX
aiua-13762	546	6	a	a	DET
aiua-13762	546	7	significant	significant	ADJ
aiua-13762	546	8	risk	risk	NOUN
aiua-13762	546	9	factor	factor	NOUN
aiua-13762	546	10	for	for	ADP
aiua-13762	546	11	crc	crc	NOUN
aiua-13762	546	12	in	in	ADP
aiua-13762	546	13	average	average	ADJ
aiua-13762	546	14	risk	risk	NOUN
aiua-13762	546	15	ashkenazi	ashkenazi	ADJ
aiua-13762	546	16	jews	jews	PROPN
aiua-13762	546	17	.	.	PUNCT
aiua-13762	547	1	eur	eur	PROPN
aiua-13762	547	2	j	j	PROPN
aiua-13762	547	3	cancer	cancer	NOUN
aiua-13762	547	4	2013	2013	NUM
aiua-13762	547	5	;	;	PUNCT
aiua-13762	547	6	49:3680	49:3680	NUM
aiua-13762	547	7	-	-	SYM
aiua-13762	547	8	5	5	NUM
aiua-13762	547	9	.	.	NOUN
aiua-13762	547	10	79	79	NUM
aiua-13762	547	11	.	.	PUNCT
aiua-13762	548	1	liang	liang	PROPN
aiua-13762	548	2	j	j	PROPN
aiua-13762	548	3	,	,	PUNCT
aiua-13762	548	4	lin	lin	PROPN
aiua-13762	548	5	c	c	PROPN
aiua-13762	548	6	,	,	PUNCT
aiua-13762	548	7	hu	hu	PROPN
aiua-13762	549	1	f	f	PROPN
aiua-13762	549	2	,	,	PUNCT
aiua-13762	549	3	et	et	PROPN
aiua-13762	549	4	al	al	PROPN
aiua-13762	549	5	.	.	PUNCT
aiua-13762	549	6	apc	apc	PROPN
aiua-13762	549	7	polymorphisms	polymorphism	NOUN
aiua-13762	549	8	and	and	CCONJ
aiua-13762	549	9	the	the	DET
aiua-13762	549	10	risk	risk	NOUN
aiua-13762	549	11	of	of	ADP
aiua-13762	549	12	colorectal	colorectal	ADJ
aiua-13762	549	13	neoplasia	neoplasia	NOUN
aiua-13762	549	14	:	:	PUNCT
aiua-13762	549	15	a	a	DET
aiua-13762	549	16	huge	huge	ADJ
aiua-13762	549	17	review	review	NOUN
aiua-13762	549	18	and	and	CCONJ
aiua-13762	549	19	meta	meta	ADJ
aiua-13762	549	20	-	-	PUNCT
aiua-13762	549	21	analysis	analysis	NOUN
aiua-13762	549	22	.	.	PUNCT
aiua-13762	550	1	am	be	AUX
aiua-13762	550	2	j	j	PROPN
aiua-13762	550	3	epidemiol	epidemiol	PROPN
aiua-13762	550	4	2013	2013	NUM
aiua-13762	550	5	;	;	PUNCT
aiua-13762	550	6	177:1169	177:1169	NUM
aiua-13762	550	7	-	-	SYM
aiua-13762	550	8	79	79	NUM
aiua-13762	550	9	.	.	PUNCT
aiua-13762	551	1	80	80	NUM
aiua-13762	551	2	.	.	PUNCT
aiua-13762	552	1	rosenblum	rosenblum	PROPN
aiua-13762	552	2	a	a	DET
aiua-13762	552	3	,	,	PUNCT
aiua-13762	552	4	springer	springer	NOUN
aiua-13762	552	5	m	m	PROPN
aiua-13762	552	6	,	,	PUNCT
aiua-13762	552	7	eppolito	eppolito	VERB
aiua-13762	552	8	a	a	X
aiua-13762	552	9	,	,	PUNCT
aiua-13762	552	10	et	et	PROPN
aiua-13762	552	11	al	al	PROPN
aiua-13762	552	12	.	.	PROPN
aiua-13762	552	13	homozygous	homozygous	PROPN
aiua-13762	552	14	germline	germline	NOUN
aiua-13762	552	15	apc	apc	PROPN
aiua-13762	552	16	p.i1307k	p.i1307k	PROPN
aiua-13762	552	17	variants	variant	NOUN
aiua-13762	552	18	:	:	PUNCT
aiua-13762	552	19	a	a	DET
aiua-13762	552	20	case	case	NOUN
aiua-13762	552	21	series	series	NOUN
aiua-13762	552	22	.	.	PUNCT
aiua-13762	553	1	case	case	NOUN
aiua-13762	553	2	rep	rep	PRON
aiua-13762	553	3	oncol	oncol	ADJ
aiua-13762	553	4	2021	2021	NUM
aiua-13762	553	5	;	;	PUNCT
aiua-13762	553	6	14:1295	14:1295	NUM
aiua-13762	553	7	-	-	SYM
aiua-13762	553	8	1303	1303	NUM
aiua-13762	553	9	.	.	PUNCT
aiua-13762	554	1	81	81	NUM
aiua-13762	554	2	.	.	PUNCT
aiua-13762	554	3	woodage	woodage	NOUN
aiua-13762	554	4	t	t	PROPN
aiua-13762	554	5	,	,	PUNCT
aiua-13762	554	6	king	king	PROPN
aiua-13762	554	7	sm	sm	PROPN
aiua-13762	554	8	,	,	PUNCT
aiua-13762	554	9	wacholder	wacholder	NOUN
aiua-13762	554	10	s	s	PROPN
aiua-13762	554	11	,	,	PUNCT
aiua-13762	554	12	et	et	PROPN
aiua-13762	554	13	al	al	PROPN
aiua-13762	554	14	.	.	PUNCT
aiua-13762	555	1	the	the	DET
aiua-13762	555	2	apci1307k	apci1307k	PROPN
aiua-13762	555	3	allele	allele	NOUN
aiua-13762	555	4	and	and	CCONJ
aiua-13762	555	5	cancer	cancer	NOUN
aiua-13762	555	6	risk	risk	NOUN
aiua-13762	555	7	in	in	ADP
aiua-13762	555	8	a	a	DET
aiua-13762	555	9	communitybased	communitybase	VERB
aiua-13762	555	10	study	study	NOUN
aiua-13762	555	11	of	of	ADP
aiua-13762	555	12	ashkenazi	ashkenazi	ADJ
aiua-13762	555	13	jews	jews	PROPN
aiua-13762	555	14	.	.	PUNCT
aiua-13762	556	1	nat	nat	PROPN
aiua-13762	556	2	genet	genet	PROPN
aiua-13762	556	3	1998	1998	NUM
aiua-13762	556	4	;	;	PUNCT
aiua-13762	556	5	20:62	20:62	NUM
aiua-13762	556	6	-	-	SYM
aiua-13762	556	7	5	5	NUM
aiua-13762	556	8	.	.	NOUN
aiua-13762	556	9	82	82	NUM
aiua-13762	556	10	.	.	PUNCT
aiua-13762	557	1	poynter	poynter	PROPN
aiua-13762	557	2	jn	jn	PROPN
aiua-13762	557	3	,	,	PUNCT
aiua-13762	557	4	cooney	cooney	PROPN
aiua-13762	557	5	ka	ka	PROPN
aiua-13762	557	6	,	,	PUNCT
aiua-13762	557	7	bonner	bonner	PROPN
aiua-13762	557	8	jd	jd	PROPN
aiua-13762	557	9	,	,	PUNCT
aiua-13762	557	10	et	et	PROPN
aiua-13762	557	11	al	al	PROPN
aiua-13762	557	12	.	.	PUNCT
aiua-13762	558	1	apc	apc	PROPN
aiua-13762	558	2	i1307k	i1307k	PROPN
aiua-13762	558	3	and	and	CCONJ
aiua-13762	558	4	the	the	DET
aiua-13762	558	5	risk	risk	NOUN
aiua-13762	558	6	of	of	ADP
aiua-13762	558	7	prostate	prostate	NOUN
aiua-13762	558	8	cancer	cancer	NOUN
aiua-13762	558	9	.	.	PUNCT
aiua-13762	559	1	cancer	cancer	NOUN
aiua-13762	559	2	epidemiol	epidemiol	PROPN
aiua-13762	559	3	biomarkers	biomarker	NOUN
aiua-13762	559	4	prev	prev	VERB
aiua-13762	559	5	2006	2006	NUM
aiua-13762	559	6	;	;	PUNCT
aiua-13762	559	7	15:468	15:468	NUM
aiua-13762	559	8	-	-	SYM
aiua-13762	559	9	73	73	NUM
aiua-13762	559	10	.	.	PUNCT
aiua-13762	560	1	83	83	NUM
aiua-13762	560	2	.	.	PUNCT
aiua-13762	561	1	economides	economides	PROPN
aiua-13762	561	2	mp	mp	PROPN
aiua-13762	561	3	,	,	PUNCT
aiua-13762	561	4	nakazawa	nakazawa	PROPN
aiua-13762	561	5	m	m	PROPN
aiua-13762	561	6	,	,	PUNCT
aiua-13762	561	7	lee	lee	PROPN
aiua-13762	561	8	jw	jw	PROPN
aiua-13762	561	9	,	,	PUNCT
aiua-13762	561	10	et	et	PROPN
aiua-13762	561	11	al	al	PROPN
aiua-13762	561	12	.	.	PROPN
aiua-13762	562	1	case	case	NOUN
aiua-13762	562	2	series	series	NOUN
aiua-13762	562	3	of	of	ADP
aiua-13762	562	4	men	man	NOUN
aiua-13762	562	5	with	with	ADP
aiua-13762	562	6	the	the	DET
aiua-13762	562	7	germline	germline	NOUN
aiua-13762	562	8	apc	apc	PROPN
aiua-13762	562	9	i1307k	i1307k	PROPN
aiua-13762	562	10	variant	variant	NOUN
aiua-13762	562	11	and	and	CCONJ
aiua-13762	562	12	treatment	treatment	NOUN
aiua-13762	562	13	-	-	PUNCT
aiua-13762	562	14	emergent	emergent	NOUN
aiua-13762	562	15	neuroendocrine	neuroendocrine	NOUN
aiua-13762	562	16	prostate	prostate	NOUN
aiua-13762	562	17	cancer	cancer	NOUN
aiua-13762	562	18	.	.	PUNCT
aiua-13762	563	1	clin	clin	PROPN
aiua-13762	563	2	genitourin	genitourin	PROPN
aiua-13762	563	3	cancer	cancer	PROPN
aiua-13762	563	4	2024	2024	NUM
aiua-13762	563	5	;	;	PUNCT
aiua-13762	563	6	22	22	NUM
aiua-13762	563	7	:	:	PUNCT
aiua-13762	563	8	e31	e31	PROPN
aiua-13762	563	9	-	-	PUNCT
aiua-13762	563	10	e37.e1	e37.e1	PROPN
aiua-13762	563	11	.	.	PROPN
aiua-13762	563	12	84	84	NUM
aiua-13762	563	13	.	.	PUNCT
aiua-13762	564	1	haraldsdottir	haraldsdottir	PROPN
aiua-13762	564	2	s	s	PROPN
aiua-13762	564	3	,	,	PUNCT
aiua-13762	564	4	hampel	hampel	PROPN
aiua-13762	564	5	h	h	NOUN
aiua-13762	564	6	,	,	PUNCT
aiua-13762	564	7	wei	wei	PROPN
aiua-13762	564	8	l	l	PROPN
aiua-13762	564	9	,	,	PUNCT
aiua-13762	564	10	et	et	PROPN
aiua-13762	564	11	al	al	PROPN
aiua-13762	564	12	.	.	PROPN
aiua-13762	565	1	prostate	prostate	NOUN
aiua-13762	565	2	cancer	cancer	NOUN
aiua-13762	565	3	incidence	incidence	NOUN
aiua-13762	565	4	in	in	ADP
aiua-13762	565	5	males	male	NOUN
aiua-13762	565	6	with	with	ADP
aiua-13762	565	7	lynch	lynch	PROPN
aiua-13762	565	8	syndrome	syndrome	PROPN
aiua-13762	565	9	.	.	PUNCT
aiua-13762	566	1	genet	genet	PROPN
aiua-13762	566	2	med	med	PROPN
aiua-13762	566	3	2014	2014	NUM
aiua-13762	566	4	;	;	PUNCT
aiua-13762	566	5	16:553	16:553	NUM
aiua-13762	566	6	-	-	SYM
aiua-13762	566	7	7	7	NUM
aiua-13762	566	8	.	.	NOUN
aiua-13762	566	9	85	85	NUM
aiua-13762	566	10	.	.	PUNCT
aiua-13762	567	1	ryan	ryan	PROPN
aiua-13762	567	2	s	s	PROPN
aiua-13762	567	3	,	,	PUNCT
aiua-13762	567	4	jenkins	jenkins	PROPN
aiua-13762	567	5	ma	ma	PROPN
aiua-13762	567	6	,	,	PUNCT
aiua-13762	567	7	win	win	PROPN
aiua-13762	567	8	ak	ak	PROPN
aiua-13762	567	9	.	.	PROPN
aiua-13762	567	10	risk	risk	NOUN
aiua-13762	567	11	of	of	ADP
aiua-13762	567	12	prostate	prostate	NOUN
aiua-13762	567	13	cancer	cancer	NOUN
aiua-13762	567	14	in	in	ADP
aiua-13762	567	15	lynch	lynch	PROPN
aiua-13762	567	16	syndrome	syndrome	PROPN
aiua-13762	567	17	:	:	PUNCT
aiua-13762	567	18	a	a	DET
aiua-13762	567	19	systematic	systematic	ADJ
aiua-13762	567	20	review	review	NOUN
aiua-13762	567	21	and	and	CCONJ
aiua-13762	567	22	meta	meta	ADJ
aiua-13762	567	23	-	-	PUNCT
aiua-13762	567	24	analysis	analysis	NOUN
aiua-13762	567	25	.	.	PUNCT
aiua-13762	568	1	cancer	cancer	NOUN
aiua-13762	568	2	epidemiol	epidemiol	PROPN
aiua-13762	568	3	biomarkers	biomarkers	PROPN
aiua-13762	568	4	prev	prev	VERB
aiua-13762	568	5	2014	2014	NUM
aiua-13762	568	6	;	;	PUNCT
aiua-13762	568	7	23:437	23:437	NUM
aiua-13762	568	8	-	-	SYM
aiua-13762	568	9	49	49	NUM
aiua-13762	568	10	.	.	PUNCT
aiua-13762	569	1	86	86	NUM
aiua-13762	569	2	.	.	PUNCT
aiua-13762	570	1	foulkes	foulkes	PROPN
aiua-13762	570	2	wd	wd	PROPN
aiua-13762	570	3	,	,	PUNCT
aiua-13762	570	4	thiffault	thiffault	PROPN
aiua-13762	571	1	i	i	PRON
aiua-13762	571	2	,	,	PUNCT
aiua-13762	571	3	gruber	gruber	PROPN
aiua-13762	571	4	sb	sb	PROPN
aiua-13762	571	5	,	,	PUNCT
aiua-13762	571	6	et	et	PROPN
aiua-13762	571	7	al	al	PROPN
aiua-13762	571	8	.	.	PUNCT
aiua-13762	572	1	the	the	DET
aiua-13762	572	2	founder	founder	NOUN
aiua-13762	572	3	mutation	mutation	NOUN
aiua-13762	572	4	msh2	msh2	PROPN
aiua-13762	572	5	*	*	SYM
aiua-13762	572	6	1906g	1906g	NUM
aiua-13762	572	7	>	>	X
aiua-13762	572	8	c	c	PROPN
aiua-13762	572	9	is	be	AUX
aiua-13762	572	10	an	an	DET
aiua-13762	572	11	important	important	ADJ
aiua-13762	572	12	cause	cause	NOUN
aiua-13762	572	13	of	of	ADP
aiua-13762	572	14	hereditary	hereditary	ADJ
aiua-13762	572	15	nonpolyposis	nonpolyposis	NOUN
aiua-13762	572	16	colorectal	colorectal	ADJ
aiua-13762	572	17	cancer	cancer	NOUN
aiua-13762	572	18	in	in	ADP
aiua-13762	572	19	the	the	DET
aiua-13762	572	20	ashkenazi	ashkenazi	ADJ
aiua-13762	572	21	jewish	jewish	ADJ
aiua-13762	572	22	population	population	NOUN
aiua-13762	572	23	.	.	PUNCT
aiua-13762	573	1	am	be	AUX
aiua-13762	573	2	j	j	PROPN
aiua-13762	573	3	hum	hum	PROPN
aiua-13762	573	4	genet	genet	PROPN
aiua-13762	573	5	2002	2002	NUM
aiua-13762	573	6	;	;	PUNCT
aiua-13762	573	7	71:1395	71:1395	NOUN
aiua-13762	573	8	-	-	SYM
aiua-13762	573	9	412	412	NUM
aiua-13762	573	10	.	.	PUNCT
aiua-13762	574	1	87	87	NUM
aiua-13762	574	2	.	.	PUNCT
aiua-13762	575	1	raskin	raskin	PROPN
aiua-13762	575	2	l	l	PROPN
aiua-13762	575	3	,	,	PUNCT
aiua-13762	575	4	schwenter	schwenter	NOUN
aiua-13762	575	5	f	f	PROPN
aiua-13762	575	6	,	,	PUNCT
aiua-13762	575	7	freytsis	freytsis	NOUN
aiua-13762	575	8	m	m	PROPN
aiua-13762	575	9	,	,	PUNCT
aiua-13762	575	10	et	et	PROPN
aiua-13762	575	11	al	al	PROPN
aiua-13762	575	12	.	.	PUNCT
aiua-13762	575	13	characterization	characterization	NOUN
aiua-13762	575	14	of	of	ADP
aiua-13762	575	15	two	two	NUM
aiua-13762	575	16	ashkenazi	ashkenazi	ADJ
aiua-13762	575	17	jewish	jewish	ADJ
aiua-13762	575	18	founder	founder	NOUN
aiua-13762	575	19	mutations	mutation	NOUN
aiua-13762	575	20	in	in	ADP
aiua-13762	575	21	msh6	msh6	NOUN
aiua-13762	575	22	gene	gene	NOUN
aiua-13762	575	23	causing	cause	VERB
aiua-13762	575	24	lynch	lynch	PROPN
aiua-13762	575	25	syndrome	syndrome	PROPN
aiua-13762	575	26	.	.	PUNCT
aiua-13762	576	1	clin	clin	PROPN
aiua-13762	576	2	genet	genet	PROPN
aiua-13762	576	3	2011	2011	NUM
aiua-13762	576	4	;	;	PUNCT
aiua-13762	576	5	79:512	79:512	NUM
aiua-13762	576	6	-	-	SYM
aiua-13762	576	7	22	22	NUM
aiua-13762	576	8	.	.	PUNCT
aiua-13762	576	9	88	88	NUM
aiua-13762	576	10	.	.	PUNCT
aiua-13762	577	1	goldberg	goldberg	PROPN
aiua-13762	577	2	y	y	PROPN
aiua-13762	577	3	,	,	PUNCT
aiua-13762	577	4	porat	porat	PROPN
aiua-13762	577	5	rm	rm	PROPN
aiua-13762	577	6	,	,	PUNCT
aiua-13762	577	7	kedar	kedar	PROPN
aiua-13762	577	8	i	i	PROPN
aiua-13762	577	9	,	,	PUNCT
aiua-13762	577	10	et	et	PROPN
aiua-13762	577	11	al	al	PROPN
aiua-13762	577	12	.	.	PUNCT
aiua-13762	578	1	an	an	DET
aiua-13762	578	2	ashkenazi	ashkenazi	ADJ
aiua-13762	578	3	founder	founder	NOUN
aiua-13762	578	4	mutation	mutation	NOUN
aiua-13762	578	5	in	in	ADP
aiua-13762	578	6	the	the	DET
aiua-13762	578	7	msh6	msh6	NOUN
aiua-13762	578	8	gene	gene	NOUN
aiua-13762	578	9	leading	lead	VERB
aiua-13762	578	10	to	to	PART
aiua-13762	578	11	hnpcc	hnpcc	VERB
aiua-13762	578	12	.	.	PUNCT
aiua-13762	579	1	fam	fam	PROPN
aiua-13762	579	2	cancer	cancer	PROPN
aiua-13762	579	3	2010	2010	NUM
aiua-13762	579	4	;	;	PUNCT
aiua-13762	579	5	9:141	9:141	X
aiua-13762	579	6	-	-	SYM
aiua-13762	579	7	50	50	NUM
aiua-13762	579	8	.	.	PUNCT
aiua-13762	579	9	89	89	NUM
aiua-13762	579	10	.	.	PUNCT
aiua-13762	580	1	laish	laish	PROPN
aiua-13762	580	2	i	i	PROPN
aiua-13762	580	3	,	,	PUNCT
aiua-13762	580	4	friedman	friedman	PROPN
aiua-13762	580	5	e	e	PROPN
aiua-13762	580	6	,	,	PUNCT
aiua-13762	580	7	levi	levi	PROPN
aiua-13762	580	8	-	-	PUNCT
aiua-13762	580	9	reznick	reznick	PROPN
aiua-13762	580	10	g	g	NOUN
aiua-13762	580	11	,	,	PUNCT
aiua-13762	580	12	et	et	PROPN
aiua-13762	580	13	al	al	PROPN
aiua-13762	580	14	.	.	PROPN
aiua-13762	581	1	double	double	ADJ
aiua-13762	581	2	heterozygotes	heterozygote	NOUN
aiua-13762	581	3	of	of	ADP
aiua-13762	581	4	brca1	brca1	PROPN
aiua-13762	581	5	/	/	SYM
aiua-13762	581	6	brca2	brca2	PROPN
aiua-13762	581	7	and	and	CCONJ
aiua-13762	581	8	mismatch	mismatch	ADJ
aiua-13762	581	9	repair	repair	NOUN
aiua-13762	581	10	gene	gene	NOUN
aiua-13762	581	11	pathogenic	pathogenic	ADJ
aiua-13762	581	12	variants	variant	NOUN
aiua-13762	581	13	:	:	PUNCT
aiua-13762	581	14	case	case	NOUN
aiua-13762	581	15	series	series	NOUN
aiua-13762	581	16	and	and	CCONJ
aiua-13762	581	17	clinical	clinical	ADJ
aiua-13762	581	18	implications	implication	NOUN
aiua-13762	581	19	.	.	PUNCT
aiua-13762	582	1	breast	breast	NOUN
aiua-13762	582	2	cancer	cancer	NOUN
aiua-13762	582	3	res	re	NOUN
aiua-13762	582	4	treat	treat	VERB
aiua-13762	582	5	2021	2021	NUM
aiua-13762	582	6	;	;	PUNCT
aiua-13762	582	7	188:685	188:685	NUM
aiua-13762	582	8	-	-	SYM
aiua-13762	582	9	694	694	NUM
aiua-13762	582	10	.	.	PUNCT
aiua-13762	583	1	90	90	NUM
aiua-13762	583	2	.	.	PUNCT
aiua-13762	583	3	tischkowitz	tischkowitz	PROPN
aiua-13762	583	4	md	md	PROPN
aiua-13762	583	5	,	,	PUNCT
aiua-13762	583	6	yilmaz	yilmaz	PROPN
aiua-13762	583	7	a	a	PROPN
aiua-13762	583	8	,	,	PUNCT
aiua-13762	583	9	chen	chen	PROPN
aiua-13762	583	10	lq	lq	PROPN
aiua-13762	583	11	,	,	PUNCT
aiua-13762	583	12	et	et	PROPN
aiua-13762	583	13	al	al	PROPN
aiua-13762	583	14	.	.	PUNCT
aiua-13762	583	15	identification	identification	NOUN
aiua-13762	583	16	and	and	CCONJ
aiua-13762	583	17	characterization	characterization	NOUN
aiua-13762	583	18	of	of	ADP
aiua-13762	583	19	novel	novel	ADJ
aiua-13762	583	20	snps	snps	PROPN
aiua-13762	583	21	in	in	ADP
aiua-13762	583	22	chek2	chek2	NOUN
aiua-13762	583	23	in	in	ADP
aiua-13762	583	24	ashkenazi	ashkenazi	ADJ
aiua-13762	583	25	jewish	jewish	ADJ
aiua-13762	583	26	men	man	NOUN
aiua-13762	583	27	with	with	ADP
aiua-13762	583	28	prostate	prostate	NOUN
aiua-13762	583	29	cancer	cancer	NOUN
aiua-13762	583	30	.	.	PUNCT
aiua-13762	584	1	cancer	cancer	NOUN
aiua-13762	584	2	lett	lett	PROPN
aiua-13762	584	3	2008	2008	NUM
aiua-13762	584	4	;	;	PUNCT
aiua-13762	584	5	270:173	270:173	PROPN
aiua-13762	584	6	-	-	SYM
aiua-13762	584	7	80	80	NUM
aiua-13762	584	8	.	.	PUNCT
aiua-13762	584	9	91	91	NUM
aiua-13762	584	10	.	.	PUNCT
aiua-13762	585	1	bar	bar	NOUN
aiua-13762	585	2	-	-	PUNCT
aiua-13762	585	3	shira	shira	PROPN
aiua-13762	585	4	a	a	PRON
aiua-13762	585	5	,	,	PUNCT
aiua-13762	585	6	matarasso	matarasso	NOUN
aiua-13762	585	7	n	n	CCONJ
aiua-13762	585	8	,	,	PUNCT
aiua-13762	585	9	rosner	rosner	PROPN
aiua-13762	585	10	s	s	PROPN
aiua-13762	585	11	,	,	PUNCT
aiua-13762	585	12	et	et	PROPN
aiua-13762	585	13	al	al	PROPN
aiua-13762	585	14	.	.	PROPN
aiua-13762	586	1	mutation	mutation	NOUN
aiua-13762	586	2	screening	screening	NOUN
aiua-13762	586	3	and	and	CCONJ
aiua-13762	586	4	association	association	NOUN
aiua-13762	586	5	study	study	NOUN
aiua-13762	586	6	of	of	ADP
aiua-13762	586	7	the	the	DET
aiua-13762	586	8	candidate	candidate	NOUN
aiua-13762	586	9	prostate	prostate	NOUN
aiua-13762	586	10	cancer	cancer	NOUN
aiua-13762	586	11	susceptibility	susceptibility	NOUN
aiua-13762	586	12	genes	gene	NOUN
aiua-13762	586	13	msr1	msr1	PROPN
aiua-13762	586	14	,	,	PUNCT
aiua-13762	586	15	pten	pten	VERB
aiua-13762	586	16	,	,	PUNCT
aiua-13762	586	17	and	and	CCONJ
aiua-13762	586	18	klf6	klf6	PROPN
aiua-13762	586	19	.	.	PUNCT
aiua-13762	587	1	prostate	prostate	NOUN
aiua-13762	587	2	2006	2006	NUM
aiua-13762	587	3	;	;	PUNCT
aiua-13762	587	4	66:1052	66:1052	NUM
aiua-13762	587	5	-	-	SYM
aiua-13762	587	6	60	60	NUM
aiua-13762	587	7	.	.	PUNCT
aiua-13762	588	1	declarations	declaration	NOUN
aiua-13762	588	2	ethical	ethical	ADJ
aiua-13762	588	3	approval	approval	NOUN
aiua-13762	588	4	:	:	PUNCT
aiua-13762	588	5	not	not	PART
aiua-13762	588	6	applicable	applicable	ADJ
aiua-13762	588	7	.	.	PUNCT
aiua-13762	589	1	availability	availability	NOUN
aiua-13762	589	2	of	of	ADP
aiua-13762	589	3	data	datum	NOUN
aiua-13762	589	4	and	and	CCONJ
aiua-13762	589	5	material	material	NOUN
aiua-13762	589	6	:	:	PUNCT
aiua-13762	589	7	not	not	PART
aiua-13762	589	8	applicable	applicable	ADJ
aiua-13762	589	9	.	.	PUNCT
aiua-13762	590	1	competing	compete	VERB
aiua-13762	590	2	interests	interest	NOUN
aiua-13762	590	3	:	:	PUNCT
aiua-13762	590	4	the	the	DET
aiua-13762	590	5	authors	author	NOUN
aiua-13762	590	6	declare	declare	VERB
aiua-13762	590	7	that	that	SCONJ
aiua-13762	590	8	they	they	PRON
aiua-13762	590	9	have	have	VERB
aiua-13762	590	10	no	no	DET
aiua-13762	590	11	competing	compete	VERB
aiua-13762	590	12	interests	interest	NOUN
aiua-13762	590	13	.	.	PUNCT
aiua-13762	591	1	funding	funding	NOUN
aiua-13762	591	2	:	:	PUNCT
aiua-13762	591	3	no	no	DET
aiua-13762	591	4	funding	funding	NOUN
aiua-13762	591	5	was	be	AUX
aiua-13762	591	6	received	receive	VERB
aiua-13762	591	7	for	for	ADP
aiua-13762	591	8	the	the	DET
aiua-13762	591	9	preparation	preparation	NOUN
aiua-13762	591	10	and	and	CCONJ
aiua-13762	591	11	publication	publication	NOUN
aiua-13762	591	12	of	of	ADP
aiua-13762	591	13	this	this	DET
aiua-13762	591	14	article	article	NOUN
aiua-13762	591	15	.	.	PUNCT
aiua-13762	592	1	authors	author	NOUN
aiua-13762	592	2	'	'	PART
aiua-13762	592	3	contributions	contribution	NOUN
aiua-13762	592	4	:	:	PUNCT
aiua-13762	592	5	project	project	NOUN
aiua-13762	592	6	concept	concept	NOUN
aiua-13762	592	7	,	,	PUNCT
aiua-13762	592	8	research	research	NOUN
aiua-13762	592	9	and	and	CCONJ
aiua-13762	592	10	manuscript	manuscript	NOUN
aiua-13762	592	11	drafting	drafting	NOUN
aiua-13762	592	12	,	,	PUNCT
aiua-13762	592	13	at	at	ADP
aiua-13762	592	14	,	,	PUNCT
aiua-13762	592	15	gp	gp	NOUN
aiua-13762	592	16	;	;	PUNCT
aiua-13762	592	17	bibliography	bibliography	NOUN
aiua-13762	592	18	research	research	NOUN
aiua-13762	592	19	,	,	PUNCT
aiua-13762	592	20	screening	screening	NOUN
aiua-13762	592	21	and	and	CCONJ
aiua-13762	592	22	data	datum	NOUN
aiua-13762	592	23	extraction	extraction	NOUN
aiua-13762	592	24	,	,	PUNCT
aiua-13762	592	25	dch	dch	PROPN
aiua-13762	592	26	,	,	PUNCT
aiua-13762	592	27	clinical	clinical	ADJ
aiua-13762	592	28	sections	section	NOUN
aiua-13762	592	29	of	of	ADP
aiua-13762	592	30	the	the	DET
aiua-13762	592	31	manuscript	manuscript	NOUN
aiua-13762	592	32	,	,	PUNCT
aiua-13762	592	33	at	at	ADP
aiua-13762	592	34	,	,	PUNCT
aiua-13762	592	35	vm	vm	PROPN
aiua-13762	592	36	,	,	PUNCT
aiua-13762	592	37	og	og	PROPN
aiua-13762	592	38	;	;	PUNCT
aiua-13762	592	39	demographic	demographic	ADJ
aiua-13762	592	40	,	,	PUNCT
aiua-13762	592	41	historical	historical	ADJ
aiua-13762	592	42	and	and	CCONJ
aiua-13762	592	43	population	population	NOUN
aiua-13762	592	44	dynamics	dynamic	NOUN
aiua-13762	592	45	sections	section	NOUN
aiua-13762	592	46	of	of	ADP
aiua-13762	592	47	the	the	DET
aiua-13762	592	48	manuscript	manuscript	NOUN
aiua-13762	592	49	and	and	CCONJ
aiua-13762	592	50	manuscript	manuscript	PROPN
aiua-13762	592	51	revision	revision	NOUN
aiua-13762	592	52	,	,	PUNCT
aiua-13762	592	53	sdp	sdp	NOUN
aiua-13762	592	54	;	;	PUNCT
aiua-13762	592	55	manuscript	manuscript	NOUN
aiua-13762	592	56	revision	revision	NOUN
aiua-13762	592	57	,	,	PUNCT
aiua-13762	592	58	og	og	PROPN
aiua-13762	592	59	,	,	PUNCT
aiua-13762	592	60	supervision	supervision	NOUN
aiua-13762	592	61	,	,	PUNCT
aiua-13762	592	62	og	og	PROPN
aiua-13762	592	63	.	.	PUNCT
aiua-13762	593	1	all	all	DET
aiua-13762	593	2	the	the	DET
aiua-13762	593	3	authors	author	NOUN
aiua-13762	593	4	read	read	VERB
aiua-13762	593	5	and	and	CCONJ
aiua-13762	593	6	approved	approve	VERB
aiua-13762	593	7	the	the	DET
aiua-13762	593	8	final	final	ADJ
aiua-13762	593	9	version	version	NOUN
aiua-13762	593	10	of	of	ADP
aiua-13762	593	11	the	the	DET
aiua-13762	593	12	manuscript	manuscript	NOUN
aiua-13762	593	13	and	and	CCONJ
aiua-13762	593	14	agreed	agree	VERB
aiua-13762	593	15	to	to	PART
aiua-13762	593	16	be	be	AUX
aiua-13762	593	17	accountable	accountable	ADJ
aiua-13762	593	18	for	for	ADP
aiua-13762	593	19	all	all	DET
aiua-13762	593	20	aspects	aspect	NOUN
aiua-13762	593	21	of	of	ADP
aiua-13762	593	22	the	the	DET
aiua-13762	593	23	work	work	NOUN
aiua-13762	593	24	.	.	PUNCT
aiua-13762	594	1	acknowledgments	acknowledgment	NOUN
aiua-13762	594	2	:	:	PUNCT
aiua-13762	594	3	none	none	NOUN
aiua-13762	594	4	.	.	PUNCT
aiua-13762	595	1	archivio	archivio	NOUN
aiua-13762	595	2	italiano	italiano	PROPN
aiua-13762	595	3	di	di	PROPN
aiua-13762	595	4	urologia	urologia	PROPN
aiua-13762	595	5	e	e	PROPN
aiua-13762	595	6	andrologia	andrologia	NOUN
aiua-13762	595	7	2025	2025	NUM
aiua-13762	595	8	;	;	PUNCT
aiua-13762	595	9	97(2):13762	97(2):13762	NUM
aiua-13762	595	10	13	13	NUM
aiua-13762	595	11	genetic	genetic	NOUN
aiua-13762	595	12	of	of	ADP
aiua-13762	595	13	prostate	prostate	NOUN
aiua-13762	595	14	cancer	cancer	NOUN
aiua-13762	595	15	92	92	NUM
aiua-13762	595	16	.	.	PUNCT
aiua-13762	596	1	abu	abu	PROPN
aiua-13762	596	2	shtaya	shtaya	PROPN
aiua-13762	596	3	a	a	PRON
aiua-13762	596	4	,	,	PUNCT
aiua-13762	596	5	kedar	kedar	PROPN
aiua-13762	596	6	i	i	PROPN
aiua-13762	596	7	,	,	PUNCT
aiua-13762	596	8	bazak	bazak	PROPN
aiua-13762	596	9	l	l	NOUN
aiua-13762	596	10	,	,	PUNCT
aiua-13762	596	11	et	et	PROPN
aiua-13762	596	12	al	al	PROPN
aiua-13762	596	13	.	.	PUNCT
aiua-13762	597	1	a	a	DET
aiua-13762	597	2	pot1	pot1	PROPN
aiua-13762	597	3	founder	founder	NOUN
aiua-13762	597	4	variant	variant	NOUN
aiua-13762	597	5	associated	associate	VERB
aiua-13762	597	6	with	with	ADP
aiua-13762	597	7	early	early	ADJ
aiua-13762	597	8	onset	onset	VERB
aiua-13762	597	9	recurrent	recurrent	ADJ
aiua-13762	597	10	melanoma	melanoma	NOUN
aiua-13762	597	11	and	and	CCONJ
aiua-13762	597	12	various	various	ADJ
aiua-13762	597	13	solid	solid	ADJ
aiua-13762	597	14	malignancies	malignancy	NOUN
aiua-13762	597	15	.	.	PUNCT
aiua-13762	598	1	genes	gene	NOUN
aiua-13762	598	2	(	(	PUNCT
aiua-13762	598	3	basel	basel	PROPN
aiua-13762	598	4	)	)	PUNCT
aiua-13762	598	5	2024	2024	NUM
aiua-13762	598	6	;	;	PUNCT
aiua-13762	598	7	15:355	15:355	NUM
aiua-13762	598	8	.	.	PUNCT
aiua-13762	598	9	93	93	NUM
aiua-13762	598	10	.	.	PUNCT
aiua-13762	599	1	giri	giri	PROPN
aiua-13762	599	2	vn	vn	PROPN
aiua-13762	599	3	,	,	PUNCT
aiua-13762	599	4	knudsen	knudsen	PROPN
aiua-13762	599	5	ke	ke	PROPN
aiua-13762	599	6	,	,	PUNCT
aiua-13762	599	7	kelly	kelly	PROPN
aiua-13762	599	8	wk	wk	PROPN
aiua-13762	599	9	,	,	PUNCT
aiua-13762	599	10	et	et	PROPN
aiua-13762	599	11	al	al	PROPN
aiua-13762	599	12	.	.	PUNCT
aiua-13762	600	1	implementation	implementation	NOUN
aiua-13762	600	2	of	of	ADP
aiua-13762	600	3	germline	germline	NOUN
aiua-13762	600	4	testing	testing	NOUN
aiua-13762	600	5	for	for	ADP
aiua-13762	600	6	prostate	prostate	NOUN
aiua-13762	600	7	cancer	cancer	NOUN
aiua-13762	600	8	:	:	PUNCT
aiua-13762	600	9	philadelphia	philadelphia	PROPN
aiua-13762	600	10	prostate	prostate	NOUN
aiua-13762	600	11	cancer	cancer	NOUN
aiua-13762	600	12	consensus	consensus	NOUN
aiua-13762	600	13	conference	conference	NOUN
aiua-13762	600	14	2019	2019	NUM
aiua-13762	600	15	.	.	PUNCT
aiua-13762	601	1	j	j	PROPN
aiua-13762	601	2	clin	clin	PROPN
aiua-13762	601	3	oncol	oncol	PROPN
aiua-13762	601	4	2020	2020	NUM
aiua-13762	601	5	;	;	PUNCT
aiua-13762	601	6	38:2798	38:2798	NUM
aiua-13762	601	7	-	-	SYM
aiua-13762	601	8	2811	2811	NUM
aiua-13762	601	9	.	.	PUNCT
aiua-13762	602	1	94	94	NUM
aiua-13762	602	2	.	.	PUNCT
aiua-13762	603	1	tuffaha	tuffaha	PROPN
aiua-13762	603	2	h	h	PROPN
aiua-13762	603	3	,	,	PUNCT
aiua-13762	603	4	edmunds	edmund	VERB
aiua-13762	603	5	k	k	PROPN
aiua-13762	603	6	,	,	PUNCT
aiua-13762	603	7	fairbairn	fairbairn	PROPN
aiua-13762	603	8	d	d	PROPN
aiua-13762	603	9	,	,	PUNCT
aiua-13762	603	10	et	et	PROPN
aiua-13762	603	11	al	al	PROPN
aiua-13762	603	12	.	.	PUNCT
aiua-13762	603	13	guidelines	guideline	NOUN
aiua-13762	603	14	for	for	ADP
aiua-13762	603	15	genetic	genetic	ADJ
aiua-13762	603	16	testing	testing	NOUN
aiua-13762	603	17	in	in	ADP
aiua-13762	603	18	prostate	prostate	NOUN
aiua-13762	603	19	cancer	cancer	NOUN
aiua-13762	603	20	:	:	PUNCT
aiua-13762	603	21	a	a	DET
aiua-13762	603	22	scoping	scope	VERB
aiua-13762	603	23	review	review	NOUN
aiua-13762	603	24	.	.	PUNCT
aiua-13762	604	1	prostate	prostate	NOUN
aiua-13762	604	2	cancer	cancer	NOUN
aiua-13762	604	3	prostatic	prostatic	ADJ
aiua-13762	604	4	dis	dis	PROPN
aiua-13762	604	5	2024	2024	NUM
aiua-13762	604	6	;	;	PUNCT
aiua-13762	604	7	27:594	27:594	NUM
aiua-13762	604	8	-	-	SYM
aiua-13762	604	9	603	603	NUM
aiua-13762	604	10	.	.	PUNCT
aiua-13762	605	1	95	95	NUM
aiua-13762	605	2	.	.	PUNCT
aiua-13762	606	1	https://www.england.nhs.uk/2024/02/nhs-launches-national-brcagene-testing-programme-toidentify-cancer-risk-early/.	https://www.england.nhs.uk/2024/02/nhs-launches-national-brcagene-testing-programme-toidentify-cancer-risk-early/.	PROPN
aiua-13762	606	2	96	96	NUM
aiua-13762	606	3	.	.	PUNCT
aiua-13762	607	1	https://www.accessdata.fda.gov/cdrh_docs/pdf17/p170019s006c	https://www.accessdata.fda.gov/cdrh_docs/pdf17/p170019s006c	PROPN
aiua-13762	607	2	.	.	PUNCT
aiua-13762	607	3	pdf	pdf	PROPN
aiua-13762	607	4	.	.	PUNCT
aiua-13762	608	1	97	97	NUM
aiua-13762	608	2	.	.	PUNCT
aiua-13762	609	1	tamir	tamir	PROPN
aiua-13762	609	2	s	s	PROPN
aiua-13762	609	3	,	,	PUNCT
aiua-13762	609	4	dahan	dahan	PROPN
aiua-13762	609	5	shemesh	shemesh	PROPN
aiua-13762	609	6	m	m	PROPN
aiua-13762	609	7	,	,	PUNCT
aiua-13762	609	8	margel	margel	ADJ
aiua-13762	609	9	d	d	NOUN
aiua-13762	609	10	,	,	PUNCT
aiua-13762	609	11	et	et	PROPN
aiua-13762	609	12	al	al	PROPN
aiua-13762	609	13	.	.	PUNCT
aiua-13762	609	14	age	age	NOUN
aiua-13762	609	15	-	-	PUNCT
aiua-13762	609	16	related	relate	VERB
aiua-13762	609	17	changes	change	NOUN
aiua-13762	609	18	of	of	ADP
aiua-13762	609	19	the	the	DET
aiua-13762	609	20	prostate	prostate	NOUN
aiua-13762	609	21	on	on	ADP
aiua-13762	609	22	magnetic	magnetic	ADJ
aiua-13762	609	23	resonance	resonance	NOUN
aiua-13762	609	24	imaging	imaging	NOUN
aiua-13762	609	25	:	:	PUNCT
aiua-13762	609	26	quantitative	quantitative	ADJ
aiua-13762	609	27	and	and	CCONJ
aiua-13762	609	28	qualitative	qualitative	ADJ
aiua-13762	609	29	evaluation	evaluation	NOUN
aiua-13762	609	30	in	in	ADP
aiua-13762	609	31	a	a	DET
aiua-13762	609	32	screening	screening	NOUN
aiua-13762	609	33	cohort	cohort	NOUN
aiua-13762	609	34	of	of	ADP
aiua-13762	609	35	brca	brca	PROPN
aiua-13762	609	36	mutation	mutation	NOUN
aiua-13762	609	37	carriers	carrier	NOUN
aiua-13762	609	38	.	.	PUNCT
aiua-13762	610	1	isr	isr	PROPN
aiua-13762	610	2	med	med	PROPN
aiua-13762	610	3	assoc	assoc	PROPN
aiua-13762	610	4	j	j	PROPN
aiua-13762	610	5	2023	2023	NUM
aiua-13762	610	6	;	;	PUNCT
aiua-13762	610	7	25:601	25:601	NUM
aiua-13762	610	8	-	-	SYM
aiua-13762	610	9	607	607	NUM
aiua-13762	610	10	.	.	PUNCT
aiua-13762	610	11	98	98	NUM
aiua-13762	610	12	.	.	PUNCT
aiua-13762	611	1	russo	russo	PROPN
aiua-13762	611	2	j	j	PROPN
aiua-13762	611	3	,	,	PUNCT
aiua-13762	611	4	giri	giri	PROPN
aiua-13762	611	5	vn	vn	PROPN
aiua-13762	611	6	.	.	PUNCT
aiua-13762	611	7	germline	germline	NOUN
aiua-13762	611	8	testing	testing	NOUN
aiua-13762	611	9	and	and	CCONJ
aiua-13762	611	10	genetic	genetic	ADJ
aiua-13762	611	11	counselling	counselling	NOUN
aiua-13762	611	12	in	in	ADP
aiua-13762	611	13	prostate	prostate	NOUN
aiua-13762	611	14	cancer	cancer	NOUN
aiua-13762	611	15	.	.	PUNCT
aiua-13762	612	1	nat	nat	PROPN
aiua-13762	612	2	rev	rev	VERB
aiua-13762	612	3	urol	urol	PROPN
aiua-13762	612	4	2022	2022	NUM
aiua-13762	612	5	;	;	PUNCT
aiua-13762	612	6	19:331	19:331	NUM
aiua-13762	612	7	-	-	SYM
aiua-13762	612	8	343	343	NUM
aiua-13762	612	9	.	.	PUNCT
aiua-13762	613	1	99	99	NUM
aiua-13762	613	2	.	.	PUNCT
aiua-13762	614	1	mohamad	mohamad	PROPN
aiua-13762	614	2	hb	hb	PROPN
aiua-13762	614	3	,	,	PUNCT
aiua-13762	614	4	apffelstaedt	apffelstaedt	PROPN
aiua-13762	614	5	jp	jp	PROPN
aiua-13762	614	6	.	.	PUNCT
aiua-13762	615	1	counseling	counseling	NOUN
aiua-13762	615	2	for	for	ADP
aiua-13762	615	3	male	male	ADJ
aiua-13762	615	4	brca	brca	PROPN
aiua-13762	615	5	mutation	mutation	NOUN
aiua-13762	615	6	carriers	carrier	NOUN
aiua-13762	615	7	:	:	PUNCT
aiua-13762	615	8	a	a	DET
aiua-13762	615	9	review	review	NOUN
aiua-13762	615	10	.	.	PUNCT
aiua-13762	616	1	breast	breast	NOUN
aiua-13762	616	2	2008	2008	NUM
aiua-13762	616	3	;	;	PUNCT
aiua-13762	616	4	17:441	17:441	NUM
aiua-13762	616	5	-	-	SYM
aiua-13762	616	6	50	50	NUM
aiua-13762	616	7	.	.	NOUN
aiua-13762	616	8	100	100	NUM
aiua-13762	616	9	.	.	PUNCT
aiua-13762	616	10	norrish	norrish	PROPN
aiua-13762	616	11	ae	ae	PROPN
aiua-13762	616	12	,	,	PUNCT
aiua-13762	616	13	ferguson	ferguson	PROPN
aiua-13762	616	14	lr	lr	PROPN
aiua-13762	616	15	,	,	PUNCT
aiua-13762	616	16	knize	knize	PROPN
aiua-13762	616	17	mg	mg	PROPN
aiua-13762	616	18	,	,	PUNCT
aiua-13762	616	19	et	et	PROPN
aiua-13762	616	20	al	al	PROPN
aiua-13762	616	21	.	.	PROPN
aiua-13762	616	22	heterocyclic	heterocyclic	ADJ
aiua-13762	616	23	amine	amine	ADJ
aiua-13762	616	24	content	content	NOUN
aiua-13762	616	25	of	of	ADP
aiua-13762	616	26	cooked	cooked	ADJ
aiua-13762	616	27	meat	meat	NOUN
aiua-13762	616	28	and	and	CCONJ
aiua-13762	616	29	risk	risk	NOUN
aiua-13762	616	30	of	of	ADP
aiua-13762	616	31	prostate	prostate	NOUN
aiua-13762	616	32	cancer	cancer	NOUN
aiua-13762	616	33	.	.	PUNCT
aiua-13762	617	1	j	j	PROPN
aiua-13762	617	2	natl	natl	PROPN
aiua-13762	617	3	cancer	cancer	PROPN
aiua-13762	617	4	inst	inst	PROPN
aiua-13762	617	5	1999	1999	NUM
aiua-13762	617	6	;	;	PUNCT
aiua-13762	617	7	91:2038	91:2038	NUM
aiua-13762	617	8	-	-	SYM
aiua-13762	617	9	44	44	NUM
aiua-13762	617	10	.	.	PUNCT
aiua-13762	618	1	101	101	NUM
aiua-13762	618	2	.	.	PUNCT
aiua-13762	619	1	reng	reng	PROPN
aiua-13762	619	2	q	q	PROPN
aiua-13762	619	3	,	,	PUNCT
aiua-13762	619	4	zhu	zhu	PROPN
aiua-13762	619	5	ll	ll	AUX
aiua-13762	619	6	,	,	PUNCT
aiua-13762	619	7	feng	feng	PROPN
aiua-13762	619	8	l	l	PROPN
aiua-13762	619	9	,	,	PUNCT
aiua-13762	619	10	et	et	PROPN
aiua-13762	619	11	al	al	PROPN
aiua-13762	619	12	.	.	PUNCT
aiua-13762	620	1	dietary	dietary	ADJ
aiua-13762	620	2	meat	meat	NOUN
aiua-13762	620	3	mutagens	mutagen	NOUN
aiua-13762	620	4	intake	intake	NOUN
aiua-13762	620	5	and	and	CCONJ
aiua-13762	620	6	cancer	cancer	NOUN
aiua-13762	620	7	risk	risk	NOUN
aiua-13762	620	8	:	:	PUNCT
aiua-13762	620	9	a	a	DET
aiua-13762	620	10	systematic	systematic	ADJ
aiua-13762	620	11	review	review	NOUN
aiua-13762	620	12	and	and	CCONJ
aiua-13762	620	13	meta	meta	ADJ
aiua-13762	620	14	-	-	PUNCT
aiua-13762	620	15	analysis	analysis	NOUN
aiua-13762	620	16	.	.	PUNCT
aiua-13762	621	1	front	front	NOUN
aiua-13762	621	2	nutr	nutr	NOUN
aiua-13762	621	3	2022	2022	NUM
aiua-13762	621	4	;	;	PUNCT
aiua-13762	621	5	9:962688	9:962688	NUM
aiua-13762	621	6	.	.	NOUN
aiua-13762	621	7	102	102	NUM
aiua-13762	621	8	.	.	PUNCT
aiua-13762	622	1	gallagher	gallagher	PROPN
aiua-13762	622	2	dj	dj	PROPN
aiua-13762	622	3	,	,	PUNCT
aiua-13762	622	4	cronin	cronin	PROPN
aiua-13762	622	5	am	be	AUX
aiua-13762	622	6	,	,	PUNCT
aiua-13762	622	7	milowsky	milowsky	PROPN
aiua-13762	622	8	mi	mi	PROPN
aiua-13762	622	9	,	,	PUNCT
aiua-13762	622	10	et	et	PROPN
aiua-13762	622	11	al	al	PROPN
aiua-13762	622	12	.	.	PROPN
aiua-13762	622	13	germline	germline	PROPN
aiua-13762	622	14	brca	brca	PROPN
aiua-13762	622	15	mutation	mutation	NOUN
aiua-13762	622	16	does	do	AUX
aiua-13762	622	17	not	not	PART
aiua-13762	622	18	prevent	prevent	VERB
aiua-13762	622	19	response	response	NOUN
aiua-13762	622	20	to	to	ADP
aiua-13762	622	21	taxane	taxane	NOUN
aiua-13762	622	22	-	-	PUNCT
aiua-13762	622	23	based	base	VERB
aiua-13762	622	24	therapy	therapy	NOUN
aiua-13762	622	25	for	for	ADP
aiua-13762	622	26	the	the	DET
aiua-13762	622	27	treatment	treatment	NOUN
aiua-13762	622	28	of	of	ADP
aiua-13762	622	29	castration	castration	NOUN
aiua-13762	622	30	-	-	PUNCT
aiua-13762	622	31	resistant	resistant	ADJ
aiua-13762	622	32	prostate	prostate	NOUN
aiua-13762	622	33	cancer	cancer	NOUN
aiua-13762	622	34	.	.	PUNCT
aiua-13762	623	1	bju	bju	NOUN
aiua-13762	623	2	int	int	PROPN
aiua-13762	623	3	2012	2012	NUM
aiua-13762	623	4	;	;	PUNCT
aiua-13762	623	5	109:713	109:713	X
aiua-13762	623	6	-	-	SYM
aiua-13762	623	7	9	9	NUM
aiua-13762	623	8	.	.	NOUN
aiua-13762	623	9	103	103	NUM
aiua-13762	623	10	.	.	X
aiua-13762	623	11	de	de	X
aiua-13762	623	12	bono	bono	PROPN
aiua-13762	623	13	j	j	PROPN
aiua-13762	623	14	,	,	PUNCT
aiua-13762	623	15	mateo	mateo	PROPN
aiua-13762	623	16	j	j	PROPN
aiua-13762	623	17	,	,	PUNCT
aiua-13762	623	18	fizazi	fizazi	PROPN
aiua-13762	623	19	k	k	PROPN
aiua-13762	623	20	,	,	PUNCT
aiua-13762	623	21	et	et	PROPN
aiua-13762	623	22	al	al	PROPN
aiua-13762	623	23	.	.	PROPN
aiua-13762	623	24	olaparib	olaparib	PROPN
aiua-13762	623	25	for	for	ADP
aiua-13762	623	26	metastatic	metastatic	ADJ
aiua-13762	623	27	castration	castration	NOUN
aiua-13762	623	28	-	-	PUNCT
aiua-13762	623	29	resistant	resistant	ADJ
aiua-13762	623	30	prostate	prostate	NOUN
aiua-13762	623	31	cancer	cancer	NOUN
aiua-13762	623	32	.	.	PUNCT
aiua-13762	624	1	n	n	PROPN
aiua-13762	625	1	engl	engl	PROPN
aiua-13762	625	2	j	j	PROPN
aiua-13762	625	3	med	med	PROPN
aiua-13762	625	4	2020	2020	NUM
aiua-13762	625	5	;	;	PUNCT
aiua-13762	625	6	382:20912102	382:20912102	NUM
aiua-13762	625	7	.	.	NOUN
aiua-13762	625	8	104	104	NUM
aiua-13762	625	9	.	.	PUNCT
aiua-13762	626	1	abida	abida	PROPN
aiua-13762	626	2	w	w	PROPN
aiua-13762	626	3	,	,	PUNCT
aiua-13762	626	4	campbell	campbell	PROPN
aiua-13762	626	5	d	d	PROPN
aiua-13762	626	6	,	,	PUNCT
aiua-13762	626	7	patnaik	patnaik	PROPN
aiua-13762	626	8	a	a	PROPN
aiua-13762	626	9	,	,	PUNCT
aiua-13762	626	10	et	et	PROPN
aiua-13762	626	11	al	al	PROPN
aiua-13762	626	12	.	.	PUNCT
aiua-13762	627	1	rucaparib	rucaparib	PROPN
aiua-13762	627	2	for	for	ADP
aiua-13762	627	3	the	the	DET
aiua-13762	627	4	treatment	treatment	NOUN
aiua-13762	627	5	of	of	ADP
aiua-13762	627	6	metastatic	metastatic	ADJ
aiua-13762	627	7	castrationresistant	castrationresistant	NOUN
aiua-13762	627	8	prostate	prostate	NOUN
aiua-13762	627	9	cancer	cancer	NOUN
aiua-13762	627	10	associated	associate	VERB
aiua-13762	627	11	with	with	ADP
aiua-13762	627	12	a	a	DET
aiua-13762	627	13	dna	dna	PROPN
aiua-13762	627	14	damage	damage	NOUN
aiua-13762	627	15	repair	repair	NOUN
aiua-13762	627	16	gene	gene	NOUN
aiua-13762	627	17	alteration	alteration	NOUN
aiua-13762	627	18	:	:	PUNCT
aiua-13762	627	19	final	final	ADJ
aiua-13762	627	20	results	result	NOUN
aiua-13762	627	21	from	from	ADP
aiua-13762	627	22	the	the	DET
aiua-13762	627	23	phase	phase	NOUN
aiua-13762	627	24	2	2	NUM
aiua-13762	627	25	triton2	triton2	NOUN
aiua-13762	627	26	study	study	NOUN
aiua-13762	627	27	.	.	PUNCT
aiua-13762	628	1	eur	eur	PROPN
aiua-13762	628	2	urol	urol	PROPN
aiua-13762	628	3	2023	2023	NUM
aiua-13762	628	4	;	;	PUNCT
aiua-13762	628	5	84:321	84:321	NUM
aiua-13762	628	6	-	-	SYM
aiua-13762	628	7	330	330	NUM
aiua-13762	628	8	.	.	PUNCT
aiua-13762	628	9	105	105	NUM
aiua-13762	628	10	.	.	PUNCT
aiua-13762	629	1	smith	smith	PROPN
aiua-13762	629	2	mr	mr	PROPN
aiua-13762	629	3	,	,	PUNCT
aiua-13762	629	4	scher	scher	PROPN
aiua-13762	629	5	hi	hi	PROPN
aiua-13762	629	6	,	,	PUNCT
aiua-13762	629	7	sandhu	sandhu	PROPN
aiua-13762	629	8	s	s	PROPN
aiua-13762	629	9	,	,	PUNCT
aiua-13762	629	10	et	et	PROPN
aiua-13762	629	11	al	al	PROPN
aiua-13762	629	12	.	.	PROPN
aiua-13762	630	1	niraparib	niraparib	PROPN
aiua-13762	630	2	in	in	ADP
aiua-13762	630	3	patients	patient	NOUN
aiua-13762	630	4	with	with	ADP
aiua-13762	630	5	metastatic	metastatic	ADJ
aiua-13762	630	6	castration	castration	NOUN
aiua-13762	630	7	-	-	PUNCT
aiua-13762	630	8	resistant	resistant	ADJ
aiua-13762	630	9	prostate	prostate	NOUN
aiua-13762	630	10	cancer	cancer	NOUN
aiua-13762	630	11	and	and	CCONJ
aiua-13762	630	12	dna	dna	PROPN
aiua-13762	630	13	repair	repair	NOUN
aiua-13762	630	14	gene	gene	NOUN
aiua-13762	630	15	defects	defect	NOUN
aiua-13762	630	16	(	(	PUNCT
aiua-13762	630	17	galahad	galahad	NOUN
aiua-13762	630	18	):	):	PUNCT
aiua-13762	630	19	a	a	DET
aiua-13762	630	20	multicentre	multicentre	NOUN
aiua-13762	630	21	,	,	PUNCT
aiua-13762	630	22	open	open	ADJ
aiua-13762	630	23	-	-	PUNCT
aiua-13762	630	24	label	label	NOUN
aiua-13762	630	25	,	,	PUNCT
aiua-13762	630	26	phase	phase	NOUN
aiua-13762	630	27	2	2	NUM
aiua-13762	630	28	trial	trial	NOUN
aiua-13762	630	29	.	.	PUNCT
aiua-13762	631	1	lancet	lancet	PROPN
aiua-13762	631	2	oncol	oncol	ADJ
aiua-13762	631	3	2022	2022	NUM
aiua-13762	631	4	;	;	PUNCT
aiua-13762	631	5	23:362	23:362	NUM
aiua-13762	631	6	-	-	SYM
aiua-13762	631	7	373	373	NUM
aiua-13762	631	8	.	.	PUNCT
aiua-13762	632	1	106	106	NUM
aiua-13762	632	2	.	.	PUNCT
aiua-13762	633	1	carmi	carmi	PROPN
aiua-13762	633	2	s	s	PROPN
aiua-13762	633	3	,	,	PUNCT
aiua-13762	633	4	hui	hui	PROPN
aiua-13762	633	5	ky	ky	PROPN
aiua-13762	633	6	,	,	PUNCT
aiua-13762	633	7	kochav	kochav	NOUN
aiua-13762	633	8	e	e	PROPN
aiua-13762	633	9	,	,	PUNCT
aiua-13762	633	10	et	et	PROPN
aiua-13762	633	11	al	al	PROPN
aiua-13762	633	12	.	.	PUNCT
aiua-13762	634	1	sequencing	sequence	VERB
aiua-13762	634	2	an	an	DET
aiua-13762	634	3	ashkenazi	ashkenazi	ADJ
aiua-13762	634	4	reference	reference	NOUN
aiua-13762	634	5	panel	panel	NOUN
aiua-13762	634	6	supports	support	VERB
aiua-13762	634	7	population	population	NOUN
aiua-13762	634	8	-	-	PUNCT
aiua-13762	634	9	targeted	target	VERB
aiua-13762	634	10	personal	personal	ADJ
aiua-13762	634	11	genomics	genomic	NOUN
aiua-13762	634	12	and	and	CCONJ
aiua-13762	634	13	illuminates	illuminate	VERB
aiua-13762	634	14	jewish	jewish	ADJ
aiua-13762	634	15	and	and	CCONJ
aiua-13762	634	16	european	european	ADJ
aiua-13762	634	17	origins	origin	NOUN
aiua-13762	634	18	.	.	PUNCT
aiua-13762	635	1	nat	nat	PROPN
aiua-13762	635	2	commun	commun	PROPN
aiua-13762	635	3	2014	2014	NUM
aiua-13762	635	4	;	;	PUNCT
aiua-13762	635	5	5:4835	5:4835	NUM
aiua-13762	635	6	.	.	PUNCT
aiua-13762	635	7	107	107	NUM
aiua-13762	635	8	.	.	PUNCT
aiua-13762	636	1	feldman	feldman	PROPN
aiua-13762	636	2	ge	ge	PROPN
aiua-13762	636	3	.	.	PUNCT
aiua-13762	637	1	do	do	AUX
aiua-13762	637	2	ashkenazi	ashkenazi	ADJ
aiua-13762	637	3	jews	jews	PROPN
aiua-13762	637	4	have	have	VERB
aiua-13762	637	5	a	a	DET
aiua-13762	637	6	higher	high	ADJ
aiua-13762	637	7	than	than	SCONJ
aiua-13762	637	8	expected	expect	VERB
aiua-13762	637	9	cancer	cancer	NOUN
aiua-13762	637	10	burden	burden	NOUN
aiua-13762	637	11	?	?	PUNCT
aiua-13762	638	1	implications	implication	NOUN
aiua-13762	638	2	for	for	ADP
aiua-13762	638	3	cancer	cancer	NOUN
aiua-13762	638	4	control	control	NOUN
aiua-13762	638	5	prioritization	prioritization	NOUN
aiua-13762	638	6	efforts	effort	NOUN
aiua-13762	638	7	.	.	PUNCT
aiua-13762	639	1	isr	isr	PROPN
aiua-13762	639	2	med	med	PROPN
aiua-13762	639	3	assoc	assoc	PROPN
aiua-13762	639	4	j	j	PROPN
aiua-13762	639	5	2001	2001	NUM
aiua-13762	639	6	;	;	PUNCT
aiua-13762	639	7	3:341	3:341	NUM
aiua-13762	639	8	-	-	SYM
aiua-13762	639	9	6	6	NUM
aiua-13762	639	10	.	.	NOUN
aiua-13762	639	11	108	108	NUM
aiua-13762	639	12	.	.	PUNCT
aiua-13762	640	1	https://www.pewresearch.org/religion/2016/03/08/intergroup-marriage-andfriendship/#:~:text=among%20haredim%	https://www.pewresearch.org/religion/2016/03/08/intergroup-marriage-andfriendship/#:~:text=among%20haredim%	PROPN
aiua-13762	640	2	20and%20	20and%20	NUM
aiua-13762	640	3	hilonim%2c%20in	hilonim%2c%20in	PROPN
aiua-13762	640	4	,	,	PUNCT
aiua-13762	640	5	have%20a%20hiloni%20s	have%20a%20hiloni%20s	NOUN
aiua-13762	640	6	pouse%2	pouse%2	ADJ
aiua-13762	640	7	fpartner	fpartner	NOUN
aiua-13762	640	8	.	.	PUNCT
aiua-13762	641	1	109	109	NUM
aiua-13762	641	2	.	.	PUNCT
aiua-13762	642	1	dellapergola	dellapergola	PROPN
aiua-13762	642	2	s.	s.	PROPN
aiua-13762	642	3	jewish	jewish	VERB
aiua-13762	642	4	out	out	ADP
aiua-13762	642	5	-	-	PUNCT
aiua-13762	642	6	marriage	marriage	NOUN
aiua-13762	642	7	:	:	PUNCT
aiua-13762	642	8	a	a	DET
aiua-13762	642	9	global	global	ADJ
aiua-13762	642	10	perspective	perspective	NOUN
aiua-13762	642	11	.	.	PUNCT
aiua-13762	643	1	in	in	ADP
aiua-13762	643	2	:	:	PUNCT
aiua-13762	643	3	reinharz	reinharz	PROPN
aiua-13762	643	4	s	s	PROPN
aiua-13762	643	5	,	,	PUNCT
aiua-13762	643	6	dellapergola	dellapergola	PROPN
aiua-13762	643	7	s	s	PROPN
aiua-13762	643	8	,	,	PUNCT
aiua-13762	643	9	eds	ed	NOUN
aiua-13762	643	10	.	.	PUNCT
aiua-13762	643	11	jewish	jewish	ADJ
aiua-13762	643	12	intermarriage	intermarriage	NOUN
aiua-13762	643	13	around	around	ADP
aiua-13762	643	14	the	the	DET
aiua-13762	643	15	world	world	NOUN
aiua-13762	643	16	.	.	PUNCT
aiua-13762	644	1	london	london	PROPN
aiua-13762	644	2	and	and	CCONJ
aiua-13762	644	3	new	new	PROPN
aiua-13762	644	4	brunswick	brunswick	PROPN
aiua-13762	644	5	:	:	PUNCT
aiua-13762	644	6	transaction	transaction	NOUN
aiua-13762	644	7	2009	2009	NUM
aiua-13762	644	8	.	.	PUNCT
aiua-13762	645	1	pp.13	pp.13	NOUN
aiua-13762	645	2	-	-	PUNCT
aiua-13762	645	3	39	39	NUM
aiua-13762	645	4	.	.	PUNCT
aiua-13762	646	1	110	110	NUM
aiua-13762	646	2	.	.	PUNCT
aiua-13762	647	1	seibert	seibert	PROPN
aiua-13762	647	2	tm	tm	PROPN
aiua-13762	647	3	,	,	PUNCT
aiua-13762	647	4	garraway	garraway	PROPN
aiua-13762	647	5	ip	ip	PROPN
aiua-13762	647	6	,	,	PUNCT
aiua-13762	647	7	plym	plym	NOUN
aiua-13762	647	8	a	a	X
aiua-13762	647	9	,	,	PUNCT
aiua-13762	647	10	et	et	PROPN
aiua-13762	647	11	al	al	PROPN
aiua-13762	647	12	.	.	PUNCT
aiua-13762	648	1	genetic	genetic	ADJ
aiua-13762	648	2	risk	risk	NOUN
aiua-13762	648	3	prediction	prediction	NOUN
aiua-13762	648	4	for	for	ADP
aiua-13762	648	5	prostate	prostate	NOUN
aiua-13762	648	6	cancer	cancer	NOUN
aiua-13762	648	7	:	:	PUNCT
aiua-13762	648	8	implications	implication	NOUN
aiua-13762	648	9	for	for	ADP
aiua-13762	648	10	early	early	ADJ
aiua-13762	648	11	detection	detection	NOUN
aiua-13762	648	12	and	and	CCONJ
aiua-13762	648	13	prevention	prevention	NOUN
aiua-13762	648	14	.	.	PUNCT
aiua-13762	649	1	eur	eur	PROPN
aiua-13762	649	2	urol	urol	PROPN
aiua-13762	649	3	2023	2023	NUM
aiua-13762	649	4	;	;	PUNCT
aiua-13762	649	5	83:241	83:241	NUM
aiua-13762	649	6	-	-	SYM
aiua-13762	649	7	248	248	NUM
aiua-13762	649	8	.	.	PUNCT
aiua-13762	650	1	correspondence	correspondence	NOUN
aiua-13762	650	2	gianpaolo	gianpaolo	NOUN
aiua-13762	650	3	perletti	perletti	PROPN
aiua-13762	650	4	(	(	PUNCT
aiua-13762	650	5	corresponding	correspond	VERB
aiua-13762	650	6	author	author	NOUN
aiua-13762	650	7	)	)	PUNCT
aiua-13762	650	8	gianpaolo.perletti@uninsubria.it	gianpaolo.perletti@uninsubria.it	PROPN
aiua-13762	650	9	department	department	PROPN
aiua-13762	650	10	of	of	ADP
aiua-13762	650	11	biotechnology	biotechnology	NOUN
aiua-13762	650	12	and	and	CCONJ
aiua-13762	650	13	life	life	NOUN
aiua-13762	650	14	sciences	science	NOUN
aiua-13762	650	15	,	,	PUNCT
aiua-13762	650	16	section	section	NOUN
aiua-13762	650	17	of	of	ADP
aiua-13762	650	18	medical	medical	ADJ
aiua-13762	650	19	and	and	CCONJ
aiua-13762	650	20	surgical	surgical	ADJ
aiua-13762	650	21	sciences	science	NOUN
aiua-13762	650	22	,	,	PUNCT
aiua-13762	650	23	university	university	NOUN
aiua-13762	650	24	of	of	ADP
aiua-13762	650	25	insubria	insubria	PROPN
aiua-13762	650	26	,	,	PUNCT
aiua-13762	650	27	varese	varese	PROPN
aiua-13762	650	28	,	,	PUNCT
aiua-13762	650	29	italy	italy	PROPN
aiua-13762	650	30	daniel	daniel	PROPN
aiua-13762	650	31	cohen	cohen	PROPN
aiua-13762	650	32	hattab	hattab	PROPN
aiua-13762	650	33	daniel.cohen-hatta@mail.huji.ac.il	daniel.cohen-hatta@mail.huji.ac.il	PROPN
aiua-13762	650	34	faculty	faculty	NOUN
aiua-13762	650	35	of	of	ADP
aiua-13762	650	36	medicine	medicine	NOUN
aiua-13762	650	37	,	,	PUNCT
aiua-13762	650	38	the	the	DET
aiua-13762	650	39	hebrew	hebrew	ADJ
aiua-13762	650	40	university	university	PROPN
aiua-13762	650	41	of	of	ADP
aiua-13762	650	42	jerusalem	jerusalem	PROPN
aiua-13762	650	43	,	,	PUNCT
aiua-13762	650	44	israel	israel	PROPN
aiua-13762	650	45	sergio	sergio	PROPN
aiua-13762	650	46	dellapergola	dellapergola	PROPN
aiua-13762	650	47	sergio.dellapergola@mail.huji.ac.il	sergio.dellapergola@mail.huji.ac.il	VERB
aiua-13762	650	48	the	the	DET
aiua-13762	650	49	harman	harman	PROPN
aiua-13762	650	50	institute	institute	PROPN
aiua-13762	650	51	of	of	ADP
aiua-13762	650	52	contemporary	contemporary	PROPN
aiua-13762	650	53	jewry	jewry	PROPN
aiua-13762	650	54	,	,	PUNCT
aiua-13762	650	55	the	the	DET
aiua-13762	650	56	hebrew	hebrew	ADJ
aiua-13762	650	57	university	university	PROPN
aiua-13762	650	58	of	of	ADP
aiua-13762	650	59	jerusalem	jerusalem	PROPN
aiua-13762	650	60	,	,	PUNCT
aiua-13762	650	61	israel	israel	PROPN
aiua-13762	650	62	ofer	ofer	AUX
aiua-13762	650	63	gofrit	gofrit	VERB
aiua-13762	650	64	ogofrit@gmail.com	ogofrit@gmail.com	PROPN
aiua-13762	651	1	department	department	PROPN
aiua-13762	651	2	of	of	ADP
aiua-13762	651	3	urology	urology	NOUN
aiua-13762	651	4	,	,	PUNCT
aiua-13762	651	5	hadassah	hadassah	PROPN
aiua-13762	651	6	hebrew	hebrew	PROPN
aiua-13762	651	7	university	university	PROPN
aiua-13762	651	8	hospital	hospital	NOUN
aiua-13762	651	9	,	,	PUNCT
aiua-13762	651	10	jerusalem	jerusalem	PROPN
aiua-13762	651	11	,	,	PUNCT
aiua-13762	651	12	israel	israel	PROPN
aiua-13762	651	13	vittorio	vittorio	PROPN
aiua-13762	651	14	magri	magri	VERB
aiua-13762	651	15	vmdoctor26@gmail.com	vmdoctor26@gmail.com	PRON
aiua-13762	651	16	urology	urology	NOUN
aiua-13762	651	17	clinic	clinic	NOUN
aiua-13762	651	18	,	,	PUNCT
aiua-13762	651	19	asst	asst	PROPN
aiua-13762	651	20	fatebenefratelli	fatebenefratelli	PROPN
aiua-13762	651	21	sacco	sacco	PROPN
aiua-13762	651	22	hospitals	hospitals	PROPN
aiua-13762	651	23	,	,	PUNCT
aiua-13762	651	24	milan	milan	PROPN
aiua-13762	651	25	,	,	PUNCT
aiua-13762	651	26	italy	italy	PROPN
aiua-13762	651	27	alberto	alberto	PROPN
aiua-13762	651	28	trinchieri	trinchieri	PROPN
aiua-13762	651	29	alberto.trinchieri@gmail.com	alberto.trinchieri@gmail.com	PROPN
aiua-13762	651	30	former	former	ADJ
aiua-13762	651	31	lecturer	lecturer	NOUN
aiua-13762	651	32	,	,	PUNCT
aiua-13762	651	33	school	school	NOUN
aiua-13762	651	34	of	of	ADP
aiua-13762	651	35	urology	urology	NOUN
aiua-13762	651	36	,	,	PUNCT
aiua-13762	651	37	university	university	PROPN
aiua-13762	651	38	of	of	ADP
aiua-13762	651	39	milan	milan	PROPN
aiua-13762	651	40	,	,	PUNCT
aiua-13762	651	41	italy	italy	PROPN