id	sid	tid	token	lemma	pos
aiua-13955	1	1	stesura	stesura	PROPN
aiua-13955	1	2	seveso	seveso	PROPN
aiua-13955	1	3	archivio	archivio	PROPN
aiua-13955	1	4	italiano	italiano	X
aiua-13955	1	5	di	di	X
aiua-13955	1	6	urologia	urologia	PROPN
aiua-13955	1	7	e	e	PROPN
aiua-13955	1	8	andrologia	andrologia	NOUN
aiua-13955	1	9	2025	2025	NUM
aiua-13955	1	10	;	;	PUNCT
aiua-13955	1	11	97(3):13955	97(3):13955	NUM
aiua-13955	1	12	1	1	NUM
aiua-13955	1	13	review	review	NOUN
aiua-13955	1	14	rcc	rcc	PROPN
aiua-13955	1	15	is	be	AUX
aiua-13955	1	16	highly	highly	ADV
aiua-13955	1	17	immunosuppressive	immunosuppressive	ADJ
aiua-13955	1	18	and	and	CCONJ
aiua-13955	1	19	inflammatory	inflammatory	ADJ
aiua-13955	1	20	,	,	PUNCT
aiua-13955	1	21	with	with	ADP
aiua-13955	1	22	cytokines	cytokine	NOUN
aiua-13955	1	23	playing	play	VERB
aiua-13955	1	24	a	a	DET
aiua-13955	1	25	pivotal	pivotal	ADJ
aiua-13955	1	26	role	role	NOUN
aiua-13955	1	27	in	in	ADP
aiua-13955	1	28	disease	disease	NOUN
aiua-13955	1	29	progression	progression	NOUN
aiua-13955	1	30	and	and	CCONJ
aiua-13955	1	31	treatment	treatment	NOUN
aiua-13955	1	32	resistance	resistance	NOUN
aiua-13955	1	33	(	(	PUNCT
aiua-13955	1	34	3	3	NUM
aiua-13955	1	35	)	)	PUNCT
aiua-13955	1	36	.	.	PUNCT
aiua-13955	2	1	among	among	ADP
aiua-13955	2	2	these	these	DET
aiua-13955	2	3	cytokines	cytokine	NOUN
aiua-13955	2	4	,	,	PUNCT
aiua-13955	2	5	interleukin-6	interleukin-6	NUM
aiua-13955	2	6	(	(	PUNCT
aiua-13955	2	7	il-6	il-6	NOUN
aiua-13955	2	8	)	)	PUNCT
aiua-13955	2	9	has	have	AUX
aiua-13955	2	10	emerged	emerge	VERB
aiua-13955	2	11	as	as	ADP
aiua-13955	2	12	a	a	DET
aiua-13955	2	13	key	key	ADJ
aiua-13955	2	14	mediator	mediator	NOUN
aiua-13955	2	15	of	of	ADP
aiua-13955	2	16	tumorigenesis	tumorigenesis	NOUN
aiua-13955	2	17	,	,	PUNCT
aiua-13955	2	18	angiogenesis	angiogenesis	NOUN
aiua-13955	2	19	,	,	PUNCT
aiua-13955	2	20	and	and	CCONJ
aiua-13955	2	21	immune	immune	ADJ
aiua-13955	2	22	evasion	evasion	NOUN
aiua-13955	2	23	,	,	PUNCT
aiua-13955	2	24	making	make	VERB
aiua-13955	2	25	it	it	PRON
aiua-13955	2	26	a	a	DET
aiua-13955	2	27	promising	promising	ADJ
aiua-13955	2	28	candidate	candidate	NOUN
aiua-13955	2	29	for	for	ADP
aiua-13955	2	30	prognostic	prognostic	ADJ
aiua-13955	2	31	evaluation	evaluation	NOUN
aiua-13955	2	32	(	(	PUNCT
aiua-13955	2	33	4	4	NUM
aiua-13955	2	34	)	)	PUNCT
aiua-13955	2	35	.	.	PUNCT
aiua-13955	3	1	il-6	il-6	PRON
aiua-13955	3	2	is	be	AUX
aiua-13955	3	3	a	a	DET
aiua-13955	3	4	pleiotropic	pleiotropic	ADJ
aiua-13955	3	5	cytokine	cytokine	NOUN
aiua-13955	3	6	involved	involve	VERB
aiua-13955	3	7	in	in	ADP
aiua-13955	3	8	acute	acute	ADJ
aiua-13955	3	9	and	and	CCONJ
aiua-13955	3	10	chronic	chronic	ADJ
aiua-13955	3	11	inflammation	inflammation	NOUN
aiua-13955	3	12	,	,	PUNCT
aiua-13955	3	13	with	with	ADP
aiua-13955	3	14	well	well	ADV
aiua-13955	3	15	-	-	PUNCT
aiua-13955	3	16	documented	document	VERB
aiua-13955	3	17	roles	role	NOUN
aiua-13955	3	18	in	in	ADP
aiua-13955	3	19	cancer	cancer	NOUN
aiua-13955	3	20	progression	progression	NOUN
aiua-13955	3	21	(	(	PUNCT
aiua-13955	3	22	4	4	NUM
aiua-13955	3	23	)	)	PUNCT
aiua-13955	3	24	.	.	PUNCT
aiua-13955	4	1	in	in	ADP
aiua-13955	4	2	rcc	rcc	PROPN
aiua-13955	4	3	,	,	PUNCT
aiua-13955	4	4	elevated	elevate	VERB
aiua-13955	4	5	il-6	il-6	NOUN
aiua-13955	4	6	levels	level	NOUN
aiua-13955	4	7	have	have	AUX
aiua-13955	4	8	been	be	AUX
aiua-13955	4	9	associated	associate	VERB
aiua-13955	4	10	with	with	ADP
aiua-13955	4	11	advanced	advanced	ADJ
aiua-13955	4	12	disease	disease	NOUN
aiua-13955	4	13	stage	stage	NOUN
aiua-13955	4	14	,	,	PUNCT
aiua-13955	4	15	poor	poor	ADJ
aiua-13955	4	16	survival	survival	NOUN
aiua-13955	4	17	,	,	PUNCT
aiua-13955	4	18	and	and	CCONJ
aiua-13955	4	19	resistance	resistance	NOUN
aiua-13955	4	20	to	to	ADP
aiua-13955	4	21	systemic	systemic	ADJ
aiua-13955	4	22	therapies	therapy	NOUN
aiua-13955	4	23	(	(	PUNCT
aiua-13955	4	24	5	5	NUM
aiua-13955	4	25	)	)	PUNCT
aiua-13955	4	26	.	.	PUNCT
aiua-13955	5	1	preclinical	preclinical	ADJ
aiua-13955	5	2	studies	study	NOUN
aiua-13955	5	3	demonstrate	demonstrate	VERB
aiua-13955	5	4	that	that	SCONJ
aiua-13955	5	5	il-6	il-6	NOUN
aiua-13955	5	6	promotes	promote	VERB
aiua-13955	5	7	tumor	tumor	NOUN
aiua-13955	5	8	growth	growth	NOUN
aiua-13955	5	9	by	by	ADP
aiua-13955	5	10	activating	activate	VERB
aiua-13955	5	11	the	the	DET
aiua-13955	5	12	jak	jak	PROPN
aiua-13955	5	13	/	/	SYM
aiua-13955	5	14	stat3	stat3	NOUN
aiua-13955	5	15	pathway	pathway	NOUN
aiua-13955	5	16	,	,	PUNCT
aiua-13955	5	17	enhancing	enhance	VERB
aiua-13955	5	18	angiogenesis	angiogenesis	NOUN
aiua-13955	5	19	through	through	ADP
aiua-13955	5	20	vegf	vegf	PROPN
aiua-13955	5	21	upregulation	upregulation	NOUN
aiua-13955	5	22	,	,	PUNCT
aiua-13955	5	23	and	and	CCONJ
aiua-13955	5	24	suppressing	suppress	VERB
aiua-13955	5	25	antitumor	antitumor	PROPN
aiua-13955	5	26	immune	immune	ADJ
aiua-13955	5	27	responses	response	NOUN
aiua-13955	5	28	(	(	PUNCT
aiua-13955	5	29	6	6	NUM
aiua-13955	5	30	)	)	PUNCT
aiua-13955	5	31	.	.	PUNCT
aiua-13955	6	1	clinically	clinically	ADV
aiua-13955	6	2	,	,	PUNCT
aiua-13955	6	3	serum	serum	PROPN
aiua-13955	6	4	il-6	il-6	NOUN
aiua-13955	6	5	levels	level	NOUN
aiua-13955	6	6	correlate	correlate	VERB
aiua-13955	6	7	with	with	ADP
aiua-13955	6	8	tumor	tumor	NOUN
aiua-13955	6	9	burden	burden	NOUN
aiua-13955	6	10	,	,	PUNCT
aiua-13955	6	11	metastatic	metastatic	ADJ
aiua-13955	6	12	potential	potential	NOUN
aiua-13955	6	13	,	,	PUNCT
aiua-13955	6	14	and	and	CCONJ
aiua-13955	6	15	adverse	adverse	ADJ
aiua-13955	6	16	outcomes	outcome	NOUN
aiua-13955	6	17	,	,	PUNCT
aiua-13955	6	18	suggesting	suggest	VERB
aiua-13955	6	19	its	its	PRON
aiua-13955	6	20	utility	utility	NOUN
aiua-13955	6	21	as	as	ADP
aiua-13955	6	22	a	a	DET
aiua-13955	6	23	non	non	ADJ
aiua-13955	6	24	-	-	ADJ
aiua-13955	6	25	invasive	invasive	ADJ
aiua-13955	6	26	biomarker	biomarker	NOUN
aiua-13955	6	27	(	(	PUNCT
aiua-13955	6	28	7	7	NUM
aiua-13955	6	29	)	)	PUNCT
aiua-13955	6	30	.	.	PUNCT
aiua-13955	7	1	however	however	ADV
aiua-13955	7	2	,	,	PUNCT
aiua-13955	7	3	existing	exist	VERB
aiua-13955	7	4	studies	study	NOUN
aiua-13955	7	5	on	on	ADP
aiua-13955	7	6	il-6	il-6	NOUN
aiua-13955	7	7	in	in	ADP
aiua-13955	7	8	rcc	rcc	PROPN
aiua-13955	7	9	have	have	AUX
aiua-13955	7	10	produced	produce	VERB
aiua-13955	7	11	heterogeneous	heterogeneous	ADJ
aiua-13955	7	12	results	result	NOUN
aiua-13955	7	13	,	,	PUNCT
aiua-13955	7	14	likely	likely	ADJ
aiua-13955	7	15	due	due	ADP
aiua-13955	7	16	to	to	ADP
aiua-13955	7	17	variations	variation	NOUN
aiua-13955	7	18	in	in	ADP
aiua-13955	7	19	assay	assay	ADJ
aiua-13955	7	20	methods	method	NOUN
aiua-13955	7	21	,	,	PUNCT
aiua-13955	7	22	patient	patient	ADJ
aiua-13955	7	23	populations	population	NOUN
aiua-13955	7	24	,	,	PUNCT
aiua-13955	7	25	and	and	CCONJ
aiua-13955	7	26	treatment	treatment	NOUN
aiua-13955	7	27	modalities	modality	NOUN
aiua-13955	7	28	.	.	PUNCT
aiua-13955	8	1	a	a	DET
aiua-13955	8	2	comprehensive	comprehensive	ADJ
aiua-13955	8	3	synthesis	synthesis	NOUN
aiua-13955	8	4	of	of	ADP
aiua-13955	8	5	these	these	DET
aiua-13955	8	6	findings	finding	NOUN
aiua-13955	8	7	is	be	AUX
aiua-13955	8	8	therefore	therefore	ADV
aiua-13955	8	9	necessary	necessary	ADJ
aiua-13955	8	10	to	to	PART
aiua-13955	8	11	clarify	clarify	VERB
aiua-13955	8	12	the	the	DET
aiua-13955	8	13	prognostic	prognostic	ADJ
aiua-13955	8	14	value	value	NOUN
aiua-13955	8	15	of	of	ADP
aiua-13955	8	16	il-6	il-6	NOUN
aiua-13955	8	17	in	in	ADP
aiua-13955	8	18	rcc	rcc	PROPN
aiua-13955	8	19	.	.	PUNCT
aiua-13955	9	1	this	this	DET
aiua-13955	9	2	meta	meta	ADJ
aiua-13955	9	3	-	-	PUNCT
aiua-13955	9	4	analysis	analysis	NOUN
aiua-13955	9	5	aims	aim	VERB
aiua-13955	9	6	to	to	PART
aiua-13955	9	7	evaluate	evaluate	VERB
aiua-13955	9	8	the	the	DET
aiua-13955	9	9	prognostic	prognostic	ADJ
aiua-13955	9	10	significance	significance	NOUN
aiua-13955	9	11	of	of	ADP
aiua-13955	9	12	il-6	il-6	NOUN
aiua-13955	9	13	in	in	ADP
aiua-13955	9	14	rcc	rcc	PROPN
aiua-13955	9	15	by	by	ADP
aiua-13955	9	16	synthesizing	synthesize	VERB
aiua-13955	9	17	data	datum	NOUN
aiua-13955	9	18	from	from	ADP
aiua-13955	9	19	published	publish	VERB
aiua-13955	9	20	studies	study	NOUN
aiua-13955	9	21	,	,	PUNCT
aiua-13955	9	22	specifically	specifically	ADV
aiua-13955	9	23	overall	overall	ADJ
aiua-13955	9	24	survival	survival	NOUN
aiua-13955	9	25	(	(	PUNCT
aiua-13955	9	26	os	os	NOUN
aiua-13955	9	27	)	)	PUNCT
aiua-13955	9	28	and	and	CCONJ
aiua-13955	9	29	progression	progression	NOUN
aiua-13955	9	30	-	-	PUNCT
aiua-13955	9	31	free	free	ADJ
aiua-13955	9	32	survival	survival	NOUN
aiua-13955	9	33	(	(	PUNCT
aiua-13955	9	34	pfs	pfs	PROPN
aiua-13955	9	35	)	)	PUNCT
aiua-13955	9	36	.	.	PUNCT
aiua-13955	10	1	methods	method	NOUN
aiua-13955	10	2	eligibility	eligibility	PROPN
aiua-13955	10	3	criteria	criteria	VERB
aiua-13955	10	4	this	this	DET
aiua-13955	10	5	meta	meta	ADJ
aiua-13955	10	6	-	-	PUNCT
aiua-13955	10	7	analysis	analysis	NOUN
aiua-13955	10	8	will	will	AUX
aiua-13955	10	9	include	include	VERB
aiua-13955	10	10	studies	study	NOUN
aiua-13955	10	11	that	that	PRON
aiua-13955	10	12	evaluate	evaluate	VERB
aiua-13955	10	13	the	the	DET
aiua-13955	10	14	association	association	NOUN
aiua-13955	10	15	between	between	ADP
aiua-13955	10	16	preoperative	preoperative	ADJ
aiua-13955	10	17	serum	serum	NOUN
aiua-13955	10	18	il-6	il-6	NOUN
aiua-13955	10	19	levels	level	NOUN
aiua-13955	10	20	and	and	CCONJ
aiua-13955	10	21	clinical	clinical	ADJ
aiua-13955	10	22	outcomes	outcome	NOUN
aiua-13955	10	23	in	in	ADP
aiua-13955	10	24	rcc	rcc	PROPN
aiua-13955	10	25	patients	patient	NOUN
aiua-13955	10	26	.	.	PUNCT
aiua-13955	11	1	inclusion	inclusion	NOUN
aiua-13955	11	2	criteria	criterion	NOUN
aiua-13955	11	3	comprise	comprise	VERB
aiua-13955	11	4	:	:	PUNCT
aiua-13955	11	5	(	(	PUNCT
aiua-13955	11	6	1	1	X
aiua-13955	11	7	)	)	PUNCT
aiua-13955	11	8	original	original	ADJ
aiua-13955	11	9	research	research	NOUN
aiua-13955	11	10	articles	article	NOUN
aiua-13955	11	11	with	with	ADP
aiua-13955	11	12	full	full	ADJ
aiua-13955	11	13	-	-	PUNCT
aiua-13955	11	14	text	text	NOUN
aiua-13955	11	15	availability	availability	NOUN
aiua-13955	11	16	in	in	ADP
aiua-13955	11	17	english	english	PROPN
aiua-13955	11	18	;	;	PUNCT
aiua-13955	11	19	(	(	PUNCT
aiua-13955	11	20	2	2	X
aiua-13955	11	21	)	)	PUNCT
aiua-13955	11	22	studies	study	NOUN
aiua-13955	11	23	measuring	measure	VERB
aiua-13955	11	24	serum	serum	NOUN
aiua-13955	11	25	il-6	il-6	NOUN
aiua-13955	11	26	levels	level	NOUN
aiua-13955	11	27	prior	prior	ADV
aiua-13955	11	28	to	to	ADP
aiua-13955	11	29	surgical	surgical	ADJ
aiua-13955	11	30	intervention	intervention	NOUN
aiua-13955	11	31	or	or	CCONJ
aiua-13955	11	32	systemic	systemic	ADJ
aiua-13955	11	33	therapy	therapy	NOUN
aiua-13955	11	34	;	;	PUNCT
aiua-13955	11	35	(	(	PUNCT
aiua-13955	11	36	3	3	X
aiua-13955	11	37	)	)	PUNCT
aiua-13955	11	38	studies	study	NOUN
aiua-13955	11	39	reporting	report	VERB
aiua-13955	11	40	correlations	correlation	NOUN
aiua-13955	11	41	between	between	ADP
aiua-13955	11	42	il-6	il-6	NUM
aiua-13955	11	43	and	and	CCONJ
aiua-13955	11	44	survival	survival	NOUN
aiua-13955	11	45	outcomes	outcome	NOUN
aiua-13955	11	46	(	(	PUNCT
aiua-13955	11	47	os	os	NOUN
aiua-13955	11	48	and	and	CCONJ
aiua-13955	11	49	pfs	pfs	PROPN
aiua-13955	11	50	)	)	PUNCT
aiua-13955	11	51	.	.	PUNCT
aiua-13955	12	1	exclusion	exclusion	NOUN
aiua-13955	12	2	criteria	criterion	NOUN
aiua-13955	12	3	are	be	AUX
aiua-13955	12	4	:	:	PUNCT
aiua-13955	12	5	(	(	PUNCT
aiua-13955	12	6	1	1	X
aiua-13955	12	7	)	)	PUNCT
aiua-13955	12	8	non	non	ADJ
aiua-13955	12	9	-	-	ADJ
aiua-13955	12	10	english	english	ADJ
aiua-13955	12	11	publications	publication	NOUN
aiua-13955	12	12	;	;	PUNCT
aiua-13955	12	13	(	(	PUNCT
aiua-13955	12	14	2	2	X
aiua-13955	12	15	)	)	PUNCT
aiua-13955	12	16	review	review	NOUN
aiua-13955	12	17	articles	article	NOUN
aiua-13955	12	18	,	,	PUNCT
aiua-13955	12	19	editorials	editorial	NOUN
aiua-13955	12	20	,	,	PUNCT
aiua-13955	12	21	case	case	NOUN
aiua-13955	12	22	reports	report	NOUN
aiua-13955	12	23	,	,	PUNCT
aiua-13955	12	24	conference	conference	NOUN
aiua-13955	12	25	abstracts	abstract	NOUN
aiua-13955	12	26	,	,	PUNCT
aiua-13955	12	27	or	or	CCONJ
aiua-13955	12	28	duplicate	duplicate	ADJ
aiua-13955	12	29	studies	study	NOUN
aiua-13955	12	30	;	;	PUNCT
aiua-13955	12	31	(	(	PUNCT
aiua-13955	12	32	3	3	X
aiua-13955	12	33	)	)	PUNCT
aiua-13955	12	34	studies	study	NOUN
aiua-13955	12	35	involving	involve	VERB
aiua-13955	12	36	patients	patient	NOUN
aiua-13955	12	37	who	who	PRON
aiua-13955	12	38	received	receive	VERB
aiua-13955	12	39	neoadjuvant	neoadjuvant	ADJ
aiua-13955	12	40	chemotherapy	chemotherapy	NOUN
aiua-13955	12	41	before	before	ADP
aiua-13955	12	42	il-6	il-6	NOUN
aiua-13955	12	43	measurement	measurement	NOUN
aiua-13955	12	44	,	,	PUNCT
aiua-13955	12	45	as	as	SCONJ
aiua-13955	12	46	these	these	DET
aiua-13955	12	47	treatments	treatment	NOUN
aiua-13955	12	48	may	may	AUX
aiua-13955	12	49	confound	confound	VERB
aiua-13955	12	50	cytokine	cytokine	ADJ
aiua-13955	12	51	levels	level	NOUN
aiua-13955	12	52	.	.	PUNCT
aiua-13955	13	1	additionally	additionally	ADV
aiua-13955	13	2	,	,	PUNCT
aiua-13955	13	3	studies	study	NOUN
aiua-13955	13	4	lacking	lack	VERB
aiua-13955	13	5	sufficient	sufficient	ADJ
aiua-13955	13	6	statistical	statistical	ADJ
aiua-13955	13	7	data	datum	NOUN
aiua-13955	13	8	for	for	ADP
aiua-13955	13	9	meta	meta	ADJ
aiua-13955	13	10	-	-	PUNCT
aiua-13955	13	11	analysis	analysis	NOUN
aiua-13955	13	12	will	will	AUX
aiua-13955	13	13	be	be	AUX
aiua-13955	13	14	excluded	exclude	VERB
aiua-13955	13	15	.	.	PUNCT
aiua-13955	14	1	introduction	introduction	NOUN
aiua-13955	14	2	&	&	CCONJ
aiua-13955	14	3	objectives	objective	NOUN
aiua-13955	14	4	:	:	PUNCT
aiua-13955	14	5	renal	renal	ADJ
aiua-13955	14	6	cell	cell	NOUN
aiua-13955	14	7	carcinoma	carcinoma	NOUN
aiua-13955	14	8	(	(	PUNCT
aiua-13955	14	9	rcc	rcc	PROPN
aiua-13955	14	10	)	)	PUNCT
aiua-13955	14	11	represents	represent	VERB
aiua-13955	14	12	the	the	DET
aiua-13955	14	13	majority	majority	NOUN
aiua-13955	14	14	of	of	ADP
aiua-13955	14	15	kidney	kidney	NOUN
aiua-13955	14	16	malignancies	malignancy	NOUN
aiua-13955	14	17	and	and	CCONJ
aiua-13955	14	18	is	be	AUX
aiua-13955	14	19	characterized	characterize	VERB
aiua-13955	14	20	by	by	ADP
aiua-13955	14	21	variable	variable	ADJ
aiua-13955	14	22	outcomes	outcome	NOUN
aiua-13955	14	23	,	,	PUNCT
aiua-13955	14	24	even	even	ADV
aiua-13955	14	25	with	with	ADP
aiua-13955	14	26	current	current	ADJ
aiua-13955	14	27	systemic	systemic	ADJ
aiua-13955	14	28	therapies	therapy	NOUN
aiua-13955	14	29	.	.	PUNCT
aiua-13955	15	1	interleukin-6	interleukin-6	NUM
aiua-13955	15	2	(	(	PUNCT
aiua-13955	15	3	il-6	il-6	NUM
aiua-13955	15	4	)	)	PUNCT
aiua-13955	15	5	,	,	PUNCT
aiua-13955	15	6	a	a	DET
aiua-13955	15	7	proinflammatory	proinflammatory	ADJ
aiua-13955	15	8	cytokine	cytokine	NOUN
aiua-13955	15	9	implicated	implicate	VERB
aiua-13955	15	10	in	in	ADP
aiua-13955	15	11	tumor	tumor	NOUN
aiua-13955	15	12	progression	progression	NOUN
aiua-13955	15	13	and	and	CCONJ
aiua-13955	15	14	immune	immune	ADJ
aiua-13955	15	15	suppression	suppression	NOUN
aiua-13955	15	16	,	,	PUNCT
aiua-13955	15	17	has	have	AUX
aiua-13955	15	18	been	be	AUX
aiua-13955	15	19	proposed	propose	VERB
aiua-13955	15	20	as	as	ADP
aiua-13955	15	21	a	a	DET
aiua-13955	15	22	prognostic	prognostic	ADJ
aiua-13955	15	23	biomarker	biomarker	NOUN
aiua-13955	15	24	in	in	ADP
aiua-13955	15	25	rcc	rcc	PROPN
aiua-13955	15	26	.	.	PUNCT
aiua-13955	16	1	however	however	ADV
aiua-13955	16	2	,	,	PUNCT
aiua-13955	16	3	the	the	DET
aiua-13955	16	4	evidence	evidence	NOUN
aiua-13955	16	5	remains	remain	VERB
aiua-13955	16	6	inconsistent	inconsistent	ADJ
aiua-13955	16	7	due	due	ADJ
aiua-13955	16	8	to	to	ADP
aiua-13955	16	9	methodological	methodological	ADJ
aiua-13955	16	10	heterogeneity	heterogeneity	NOUN
aiua-13955	16	11	across	across	ADP
aiua-13955	16	12	studies	study	NOUN
aiua-13955	16	13	.	.	PUNCT
aiua-13955	17	1	therefore	therefore	ADV
aiua-13955	17	2	,	,	PUNCT
aiua-13955	17	3	our	our	PRON
aiua-13955	17	4	study	study	NOUN
aiua-13955	17	5	aims	aim	VERB
aiua-13955	17	6	to	to	PART
aiua-13955	17	7	evaluate	evaluate	VERB
aiua-13955	17	8	the	the	DET
aiua-13955	17	9	prognostic	prognostic	ADJ
aiua-13955	17	10	significance	significance	NOUN
aiua-13955	17	11	of	of	ADP
aiua-13955	17	12	il-6	il-6	NOUN
aiua-13955	17	13	in	in	ADP
aiua-13955	17	14	rcc	rcc	PROPN
aiua-13955	17	15	by	by	ADP
aiua-13955	17	16	synthesizing	synthesize	VERB
aiua-13955	17	17	data	datum	NOUN
aiua-13955	17	18	from	from	ADP
aiua-13955	17	19	published	publish	VERB
aiua-13955	17	20	studies	study	NOUN
aiua-13955	17	21	,	,	PUNCT
aiua-13955	17	22	specifically	specifically	ADV
aiua-13955	17	23	overall	overall	ADJ
aiua-13955	17	24	survival	survival	NOUN
aiua-13955	17	25	(	(	PUNCT
aiua-13955	17	26	os	os	NOUN
aiua-13955	17	27	)	)	PUNCT
aiua-13955	17	28	and	and	CCONJ
aiua-13955	17	29	progression	progression	NOUN
aiua-13955	17	30	-	-	PUNCT
aiua-13955	17	31	free	free	ADJ
aiua-13955	17	32	survival	survival	NOUN
aiua-13955	17	33	(	(	PUNCT
aiua-13955	17	34	pfs	pfs	PROPN
aiua-13955	17	35	)	)	PUNCT
aiua-13955	17	36	.	.	PUNCT
aiua-13955	18	1	methods	method	NOUN
aiua-13955	18	2	:	:	PUNCT
aiua-13955	18	3	a	a	DET
aiua-13955	18	4	systematic	systematic	ADJ
aiua-13955	18	5	meta	meta	ADJ
aiua-13955	18	6	-	-	PUNCT
aiua-13955	18	7	analysis	analysis	NOUN
aiua-13955	18	8	was	be	AUX
aiua-13955	18	9	conducted	conduct	VERB
aiua-13955	18	10	to	to	PART
aiua-13955	18	11	evaluate	evaluate	VERB
aiua-13955	18	12	the	the	DET
aiua-13955	18	13	prognostic	prognostic	ADJ
aiua-13955	18	14	significance	significance	NOUN
aiua-13955	18	15	of	of	ADP
aiua-13955	18	16	il-6	il-6	NOUN
aiua-13955	18	17	in	in	ADP
aiua-13955	18	18	rcc	rcc	PROPN
aiua-13955	18	19	.	.	PUNCT
aiua-13955	19	1	eligible	eligible	ADJ
aiua-13955	19	2	studies	study	NOUN
aiua-13955	19	3	were	be	AUX
aiua-13955	19	4	identified	identify	VERB
aiua-13955	19	5	through	through	ADP
aiua-13955	19	6	pubmed	pubmed	PROPN
aiua-13955	19	7	,	,	PUNCT
aiua-13955	19	8	sciencedirect	sciencedirect	PROPN
aiua-13955	19	9	,	,	PUNCT
aiua-13955	19	10	and	and	CCONJ
aiua-13955	19	11	proquest	proquest	X
aiua-13955	19	12	up	up	ADP
aiua-13955	19	13	to	to	ADP
aiua-13955	19	14	march	march	PROPN
aiua-13955	19	15	2025	2025	NUM
aiua-13955	19	16	.	.	PUNCT
aiua-13955	20	1	inclusion	inclusion	NOUN
aiua-13955	20	2	criteria	criterion	NOUN
aiua-13955	20	3	encompassed	encompass	VERB
aiua-13955	20	4	original	original	ADJ
aiua-13955	20	5	articles	article	NOUN
aiua-13955	20	6	measuring	measure	VERB
aiua-13955	20	7	pre	pre	ADJ
aiua-13955	20	8	-	-	ADJ
aiua-13955	20	9	treatment	treatment	ADJ
aiua-13955	20	10	serum	serum	NOUN
aiua-13955	20	11	il-6	il-6	NOUN
aiua-13955	20	12	levels	level	NOUN
aiua-13955	20	13	in	in	ADP
aiua-13955	20	14	rcc	rcc	PROPN
aiua-13955	20	15	patients	patient	NOUN
aiua-13955	20	16	and	and	CCONJ
aiua-13955	20	17	reporting	report	VERB
aiua-13955	20	18	associations	association	NOUN
aiua-13955	20	19	with	with	ADP
aiua-13955	20	20	overall	overall	ADJ
aiua-13955	20	21	survival	survival	NOUN
aiua-13955	20	22	(	(	PUNCT
aiua-13955	20	23	os	os	NOUN
aiua-13955	20	24	)	)	PUNCT
aiua-13955	20	25	or	or	CCONJ
aiua-13955	20	26	progressionfree	progressionfree	ADJ
aiua-13955	20	27	survival	survival	NOUN
aiua-13955	20	28	(	(	PUNCT
aiua-13955	20	29	pfs	pfs	PROPN
aiua-13955	20	30	)	)	PUNCT
aiua-13955	20	31	.	.	PUNCT
aiua-13955	21	1	random	random	ADJ
aiua-13955	21	2	-	-	PUNCT
aiua-13955	21	3	effects	effect	NOUN
aiua-13955	21	4	models	model	NOUN
aiua-13955	21	5	were	be	AUX
aiua-13955	21	6	used	use	VERB
aiua-13955	21	7	to	to	PART
aiua-13955	21	8	compute	compute	VERB
aiua-13955	21	9	pooled	pool	VERB
aiua-13955	21	10	hazard	hazard	NOUN
aiua-13955	21	11	ratios	ratio	NOUN
aiua-13955	21	12	(	(	PUNCT
aiua-13955	21	13	hrs	hrs	NOUN
aiua-13955	21	14	)	)	PUNCT
aiua-13955	21	15	and	and	CCONJ
aiua-13955	21	16	survival	survival	NOUN
aiua-13955	21	17	differences	difference	NOUN
aiua-13955	21	18	.	.	PUNCT
aiua-13955	22	1	results	result	NOUN
aiua-13955	22	2	:	:	PUNCT
aiua-13955	22	3	nine	nine	NUM
aiua-13955	22	4	studies	study	NOUN
aiua-13955	22	5	comprising	comprise	VERB
aiua-13955	22	6	702	702	NUM
aiua-13955	22	7	rcc	rcc	NOUN
aiua-13955	22	8	patients	patient	NOUN
aiua-13955	22	9	were	be	AUX
aiua-13955	22	10	included	include	VERB
aiua-13955	22	11	.	.	PUNCT
aiua-13955	23	1	patients	patient	NOUN
aiua-13955	23	2	with	with	ADP
aiua-13955	23	3	low	low	ADJ
aiua-13955	23	4	il-6	il-6	NOUN
aiua-13955	23	5	levels	level	NOUN
aiua-13955	23	6	had	have	VERB
aiua-13955	23	7	significantly	significantly	ADV
aiua-13955	23	8	longer	long	ADJ
aiua-13955	23	9	os	os	NOUN
aiua-13955	23	10	(	(	PUNCT
aiua-13955	23	11	difference	difference	NOUN
aiua-13955	23	12	:	:	PUNCT
aiua-13955	23	13	5.36	5.36	NUM
aiua-13955	23	14	months	month	NOUN
aiua-13955	23	15	;	;	PUNCT
aiua-13955	23	16	95	95	NUM
aiua-13955	23	17	%	%	NOUN
aiua-13955	23	18	ci	ci	NOUN
aiua-13955	23	19	:	:	PUNCT
aiua-13955	23	20	2.2	2.2	NUM
aiua-13955	23	21	-	-	SYM
aiua-13955	23	22	8.53	8.53	NUM
aiua-13955	23	23	;	;	PUNCT
aiua-13955	23	24	p	p	X
aiua-13955	23	25	<	<	X
aiua-13955	23	26	0.001	0.001	NUM
aiua-13955	23	27	;	;	PUNCT
aiua-13955	23	28	i²	i²	NOUN
aiua-13955	23	29	=	=	SYM
aiua-13955	23	30	0	0	NUM
aiua-13955	23	31	%	%	NOUN
aiua-13955	23	32	)	)	PUNCT
aiua-13955	23	33	and	and	CCONJ
aiua-13955	23	34	pfs	pfs	PROPN
aiua-13955	23	35	(	(	PUNCT
aiua-13955	23	36	difference	difference	NOUN
aiua-13955	23	37	:	:	PUNCT
aiua-13955	23	38	6.41	6.41	NUM
aiua-13955	23	39	months	month	NOUN
aiua-13955	23	40	;	;	PUNCT
aiua-13955	23	41	95	95	NUM
aiua-13955	23	42	%	%	NOUN
aiua-13955	23	43	ci	ci	NOUN
aiua-13955	23	44	:	:	PUNCT
aiua-13955	23	45	1.3	1.3	NUM
aiua-13955	23	46	-	-	SYM
aiua-13955	23	47	11.53	11.53	NUM
aiua-13955	23	48	;	;	PUNCT
aiua-13955	23	49	p	p	X
aiua-13955	23	50	=	=	NOUN
aiua-13955	23	51	0.01	0.01	NUM
aiua-13955	23	52	;	;	PUNCT
aiua-13955	23	53	i²	i²	NOUN
aiua-13955	23	54	=	=	NOUN
aiua-13955	23	55	48.5	48.5	NUM
aiua-13955	23	56	%	%	NOUN
aiua-13955	23	57	)	)	PUNCT
aiua-13955	23	58	compared	compare	VERB
aiua-13955	23	59	to	to	ADP
aiua-13955	23	60	those	those	PRON
aiua-13955	23	61	with	with	ADP
aiua-13955	23	62	high	high	ADJ
aiua-13955	23	63	il-6	il-6	NOUN
aiua-13955	23	64	.	.	PUNCT
aiua-13955	24	1	the	the	DET
aiua-13955	24	2	pooled	pool	VERB
aiua-13955	24	3	hr	hr	NOUN
aiua-13955	24	4	for	for	ADP
aiua-13955	24	5	survival	survival	NOUN
aiua-13955	24	6	associated	associate	VERB
aiua-13955	24	7	with	with	ADP
aiua-13955	24	8	elevated	elevated	ADJ
aiua-13955	24	9	il-6	il-6	NUM
aiua-13955	24	10	was	be	AUX
aiua-13955	24	11	2.06	2.06	NUM
aiua-13955	24	12	(	(	PUNCT
aiua-13955	24	13	95	95	NUM
aiua-13955	24	14	%	%	NOUN
aiua-13955	24	15	ci	ci	NOUN
aiua-13955	24	16	:	:	PUNCT
aiua-13955	24	17	-0.23	-0.23	NUM
aiua-13955	24	18	-	-	PUNCT
aiua-13955	24	19	4.36	4.36	NUM
aiua-13955	24	20	)	)	PUNCT
aiua-13955	24	21	,	,	PUNCT
aiua-13955	24	22	with	with	ADP
aiua-13955	24	23	considerable	considerable	ADJ
aiua-13955	24	24	heterogeneity	heterogeneity	NOUN
aiua-13955	24	25	(	(	PUNCT
aiua-13955	24	26	i²	i²	NOUN
aiua-13955	24	27	=	=	PUNCT
aiua-13955	24	28	89.19	89.19	NUM
aiua-13955	24	29	%	%	NOUN
aiua-13955	24	30	)	)	PUNCT
aiua-13955	24	31	and	and	CCONJ
aiua-13955	24	32	borderline	borderline	ADJ
aiua-13955	24	33	statistical	statistical	ADJ
aiua-13955	24	34	significance	significance	NOUN
aiua-13955	24	35	(	(	PUNCT
aiua-13955	24	36	p	p	NOUN
aiua-13955	24	37	=	=	NOUN
aiua-13955	24	38	0.08	0.08	NUM
aiua-13955	24	39	)	)	PUNCT
aiua-13955	24	40	.	.	PUNCT
aiua-13955	25	1	despite	despite	SCONJ
aiua-13955	25	2	variations	variation	NOUN
aiua-13955	25	3	in	in	ADP
aiua-13955	25	4	study	study	NOUN
aiua-13955	25	5	design	design	NOUN
aiua-13955	25	6	,	,	PUNCT
aiua-13955	25	7	sample	sample	NOUN
aiua-13955	25	8	size	size	NOUN
aiua-13955	25	9	,	,	PUNCT
aiua-13955	25	10	and	and	CCONJ
aiua-13955	25	11	il-6	il-6	NOUN
aiua-13955	25	12	detection	detection	NOUN
aiua-13955	25	13	methods	method	NOUN
aiua-13955	25	14	,	,	PUNCT
aiua-13955	25	15	elevated	elevate	VERB
aiua-13955	25	16	il-6	il-6	PRON
aiua-13955	25	17	consistently	consistently	ADV
aiua-13955	25	18	predicted	predict	VERB
aiua-13955	25	19	worse	bad	ADJ
aiua-13955	25	20	clinical	clinical	ADJ
aiua-13955	25	21	outcomes	outcome	NOUN
aiua-13955	25	22	.	.	PUNCT
aiua-13955	26	1	conclusions	conclusion	NOUN
aiua-13955	26	2	:	:	PUNCT
aiua-13955	26	3	il-6	il-6	NUM
aiua-13955	26	4	is	be	AUX
aiua-13955	26	5	a	a	DET
aiua-13955	26	6	promising	promising	ADJ
aiua-13955	26	7	prognostic	prognostic	ADJ
aiua-13955	26	8	biomarker	biomarker	NOUN
aiua-13955	26	9	in	in	ADP
aiua-13955	26	10	rcc	rcc	PROPN
aiua-13955	26	11	,	,	PUNCT
aiua-13955	26	12	with	with	ADP
aiua-13955	26	13	elevated	elevated	ADJ
aiua-13955	26	14	levels	level	NOUN
aiua-13955	26	15	associated	associate	VERB
aiua-13955	26	16	with	with	ADP
aiua-13955	26	17	significantly	significantly	ADV
aiua-13955	26	18	poorer	poor	ADJ
aiua-13955	26	19	os	os	NOUN
aiua-13955	26	20	and	and	CCONJ
aiua-13955	26	21	pfs	pfs	PROPN
aiua-13955	26	22	.	.	PUNCT
aiua-13955	27	1	key	key	ADJ
aiua-13955	27	2	words	word	NOUN
aiua-13955	27	3	:	:	PUNCT
aiua-13955	27	4	renal	renal	ADJ
aiua-13955	27	5	cell	cell	NOUN
aiua-13955	27	6	carcinoma	carcinoma	NOUN
aiua-13955	27	7	;	;	PUNCT
aiua-13955	27	8	interleukin-6	interleukin-6	NUM
aiua-13955	27	9	;	;	PUNCT
aiua-13955	27	10	prognosis	prognosis	NOUN
aiua-13955	27	11	;	;	PUNCT
aiua-13955	27	12	survival	survival	NOUN
aiua-13955	27	13	;	;	PUNCT
aiua-13955	27	14	biomarker	biomarker	NOUN
aiua-13955	27	15	submitted	submit	VERB
aiua-13955	27	16	10	10	NUM
aiua-13955	27	17	may	may	PROPN
aiua-13955	27	18	2025	2025	NUM
aiua-13955	27	19	;	;	PUNCT
aiua-13955	27	20	accepted	accept	VERB
aiua-13955	27	21	17	17	NUM
aiua-13955	27	22	may	may	AUX
aiua-13955	27	23	2025	2025	NUM
aiua-13955	27	24	introduction	introduction	NOUN
aiua-13955	27	25	renal	renal	ADJ
aiua-13955	27	26	cell	cell	NOUN
aiua-13955	27	27	carcinoma	carcinoma	NOUN
aiua-13955	27	28	(	(	PUNCT
aiua-13955	27	29	rcc	rcc	PROPN
aiua-13955	27	30	)	)	PUNCT
aiua-13955	27	31	accounts	account	VERB
aiua-13955	27	32	for	for	ADP
aiua-13955	27	33	approximately	approximately	ADV
aiua-13955	27	34	90	90	NUM
aiua-13955	27	35	%	%	NOUN
aiua-13955	27	36	of	of	ADP
aiua-13955	27	37	all	all	DET
aiua-13955	27	38	kidney	kidney	NOUN
aiua-13955	27	39	cancers	cancer	NOUN
aiua-13955	27	40	and	and	CCONJ
aiua-13955	27	41	remains	remain	VERB
aiua-13955	27	42	a	a	DET
aiua-13955	27	43	significant	significant	ADJ
aiua-13955	27	44	cause	cause	NOUN
aiua-13955	27	45	of	of	ADP
aiua-13955	27	46	cancer	cancer	NOUN
aiua-13955	27	47	-	-	PUNCT
aiua-13955	27	48	related	relate	VERB
aiua-13955	27	49	morbidity	morbidity	NOUN
aiua-13955	27	50	and	and	CCONJ
aiua-13955	27	51	mortality	mortality	NOUN
aiua-13955	27	52	worldwide	worldwide	ADV
aiua-13955	27	53	(	(	PUNCT
aiua-13955	27	54	1	1	NUM
aiua-13955	27	55	)	)	PUNCT
aiua-13955	27	56	.	.	PUNCT
aiua-13955	28	1	despite	despite	SCONJ
aiua-13955	28	2	advancements	advancement	NOUN
aiua-13955	28	3	in	in	ADP
aiua-13955	28	4	targeted	target	VERB
aiua-13955	28	5	therapies	therapy	NOUN
aiua-13955	28	6	and	and	CCONJ
aiua-13955	28	7	immune	immune	ADJ
aiua-13955	28	8	checkpoint	checkpoint	NOUN
aiua-13955	28	9	inhibitors	inhibitor	NOUN
aiua-13955	28	10	,	,	PUNCT
aiua-13955	28	11	patient	patient	ADJ
aiua-13955	28	12	outcomes	outcome	NOUN
aiua-13955	28	13	vary	vary	VERB
aiua-13955	28	14	widely	widely	ADV
aiua-13955	28	15	(	(	PUNCT
aiua-13955	28	16	2	2	NUM
aiua-13955	28	17	)	)	PUNCT
aiua-13955	28	18	,	,	PUNCT
aiua-13955	28	19	underscoring	underscore	VERB
aiua-13955	28	20	the	the	DET
aiua-13955	28	21	need	need	NOUN
aiua-13955	28	22	for	for	ADP
aiua-13955	28	23	reliable	reliable	ADJ
aiua-13955	28	24	prognostic	prognostic	ADJ
aiua-13955	28	25	biomarkers	biomarker	NOUN
aiua-13955	28	26	to	to	PART
aiua-13955	28	27	guide	guide	VERB
aiua-13955	28	28	clinical	clinical	ADJ
aiua-13955	28	29	decision	decision	NOUN
aiua-13955	28	30	-	-	PUNCT
aiua-13955	28	31	making	making	NOUN
aiua-13955	28	32	.	.	PUNCT
aiua-13955	29	1	the	the	DET
aiua-13955	29	2	tumor	tumor	NOUN
aiua-13955	29	3	microenvironment	microenvironment	NOUN
aiua-13955	29	4	in	in	ADP
aiua-13955	29	5	circulating	circulate	VERB
aiua-13955	29	6	il-6	il-6	NOUN
aiua-13955	29	7	and	and	CCONJ
aiua-13955	29	8	survival	survival	NOUN
aiua-13955	29	9	outcomes	outcome	NOUN
aiua-13955	29	10	in	in	ADP
aiua-13955	29	11	renal	renal	ADJ
aiua-13955	29	12	cell	cell	NOUN
aiua-13955	29	13	carcinoma	carcinoma	NOUN
aiua-13955	29	14	:	:	PUNCT
aiua-13955	29	15	a	a	DET
aiua-13955	29	16	systematic	systematic	ADJ
aiua-13955	29	17	review	review	NOUN
aiua-13955	29	18	and	and	CCONJ
aiua-13955	29	19	meta	meta	ADJ
aiua-13955	29	20	-	-	PUNCT
aiua-13955	29	21	analysis	analysis	NOUN
aiua-13955	29	22	haryo	haryo	NOUN
aiua-13955	29	23	nindito	nindito	PROPN
aiua-13955	29	24	wicaksono	wicaksono	PROPN
aiua-13955	29	25	1	1	NUM
aiua-13955	29	26	,	,	PUNCT
aiua-13955	29	27	taufiq	taufiq	PROPN
aiua-13955	29	28	nur	nur	PROPN
aiua-13955	29	29	budaya	budaya	VERB
aiua-13955	29	30	2	2	NUM
aiua-13955	29	31	,	,	PUNCT
aiua-13955	29	32	kurnia	kurnia	PROPN
aiua-13955	29	33	penta	penta	PROPN
aiua-13955	29	34	seputra	seputra	PROPN
aiua-13955	29	35	2	2	NUM
aiua-13955	29	36	,	,	PUNCT
aiua-13955	29	37	aulia	aulia	PROPN
aiua-13955	29	38	rahman	rahman	PROPN
aiua-13955	29	39	putra	putra	PROPN
aiua-13955	29	40	2	2	NUM
aiua-13955	29	41	1	1	NUM
aiua-13955	29	42	general	general	ADJ
aiua-13955	29	43	practicioner	practicioner	NOUN
aiua-13955	29	44	,	,	PUNCT
aiua-13955	29	45	intern	intern	NOUN
aiua-13955	29	46	at	at	ADP
aiua-13955	29	47	department	department	PROPN
aiua-13955	29	48	of	of	ADP
aiua-13955	29	49	urology	urology	NOUN
aiua-13955	29	50	,	,	PUNCT
aiua-13955	29	51	faculty	faculty	NOUN
aiua-13955	29	52	of	of	ADP
aiua-13955	29	53	medicine	medicine	NOUN
aiua-13955	29	54	,	,	PUNCT
aiua-13955	29	55	universitas	universita	NOUN
aiua-13955	29	56	brawijaya	brawijaya	NOUN
aiua-13955	29	57	,	,	PUNCT
aiua-13955	29	58	saiful	saiful	PROPN
aiua-13955	29	59	anwar	anwar	PROPN
aiua-13955	29	60	general	general	PROPN
aiua-13955	29	61	hospital	hospital	PROPN
aiua-13955	29	62	,	,	PUNCT
aiua-13955	29	63	malang	malang	PROPN
aiua-13955	29	64	,	,	PUNCT
aiua-13955	29	65	indonesia	indonesia	PROPN
aiua-13955	29	66	;	;	PUNCT
aiua-13955	29	67	2	2	NUM
aiua-13955	29	68	department	department	NOUN
aiua-13955	29	69	of	of	ADP
aiua-13955	29	70	urology	urology	NOUN
aiua-13955	29	71	,	,	PUNCT
aiua-13955	29	72	faculty	faculty	NOUN
aiua-13955	29	73	of	of	ADP
aiua-13955	29	74	medicine	medicine	NOUN
aiua-13955	29	75	,	,	PUNCT
aiua-13955	29	76	universitas	universita	NOUN
aiua-13955	29	77	brawijaya	brawijaya	NOUN
aiua-13955	29	78	,	,	PUNCT
aiua-13955	29	79	saiful	saiful	PROPN
aiua-13955	29	80	anwar	anwar	PROPN
aiua-13955	29	81	general	general	PROPN
aiua-13955	29	82	hospital	hospital	PROPN
aiua-13955	29	83	,	,	PUNCT
aiua-13955	29	84	malang	malang	PROPN
aiua-13955	29	85	,	,	PUNCT
aiua-13955	29	86	indonesia	indonesia	PROPN
aiua-13955	29	87	.	.	PUNCT
aiua-13955	30	1	doi	doi	PROPN
aiua-13955	30	2	:	:	PUNCT
aiua-13955	30	3	10.4081	10.4081	NUM
aiua-13955	30	4	/	/	SYM
aiua-13955	30	5	aiua.2025.13955	aiua.2025.13955	NOUN
aiua-13955	30	6	summary	summary	NOUN
aiua-13955	30	7	archivio	archivio	NOUN
aiua-13955	30	8	italiano	italiano	NOUN
aiua-13955	30	9	di	di	X
aiua-13955	30	10	urologia	urologia	PROPN
aiua-13955	30	11	e	e	PROPN
aiua-13955	30	12	andrologia	andrologia	NOUN
aiua-13955	30	13	2025	2025	NUM
aiua-13955	30	14	;	;	PUNCT
aiua-13955	30	15	97(3):13955	97(3):13955	NUM
aiua-13955	30	16	h.	h.	NOUN
aiua-13955	30	17	nindito	nindito	PROPN
aiua-13955	30	18	wicaksono	wicaksono	PROPN
aiua-13955	30	19	,	,	PUNCT
aiua-13955	30	20	t.	t.	PROPN
aiua-13955	30	21	nur	nur	PROPN
aiua-13955	30	22	budaya	budaya	PROPN
aiua-13955	30	23	,	,	PUNCT
aiua-13955	30	24	k.	k.	PROPN
aiua-13955	30	25	penta	penta	PROPN
aiua-13955	30	26	seputra	seputra	PROPN
aiua-13955	30	27	,	,	PUNCT
aiua-13955	30	28	a.	a.	PROPN
aiua-13955	30	29	rahman	rahman	PROPN
aiua-13955	30	30	putra	putra	PROPN
aiua-13955	30	31	2	2	NUM
aiua-13955	30	32	literature	literature	NOUN
aiua-13955	30	33	search	search	NOUN
aiua-13955	30	34	a	a	DET
aiua-13955	30	35	systematic	systematic	ADJ
aiua-13955	30	36	search	search	NOUN
aiua-13955	30	37	will	will	AUX
aiua-13955	30	38	be	be	AUX
aiua-13955	30	39	conducted	conduct	VERB
aiua-13955	30	40	in	in	ADP
aiua-13955	30	41	pubmed	pubmed	PROPN
aiua-13955	30	42	/	/	SYM
aiua-13955	30	43	medline	medline	PROPN
aiua-13955	30	44	,	,	PUNCT
aiua-13955	30	45	science	science	NOUN
aiua-13955	30	46	direct	direct	ADJ
aiua-13955	30	47	,	,	PUNCT
aiua-13955	30	48	and	and	CCONJ
aiua-13955	30	49	proquest	proquest	PROPN
aiua-13955	30	50	,	,	PUNCT
aiua-13955	30	51	from	from	ADP
aiua-13955	30	52	inception	inception	NOUN
aiua-13955	30	53	to	to	ADP
aiua-13955	30	54	the	the	DET
aiua-13955	30	55	present	present	NOUN
aiua-13955	30	56	,	,	PUNCT
aiua-13955	30	57	using	use	VERB
aiua-13955	30	58	predefined	predefine	VERB
aiua-13955	30	59	search	search	NOUN
aiua-13955	30	60	terms	term	NOUN
aiua-13955	30	61	:	:	PUNCT
aiua-13955	30	62	−	−	NUM
aiua-13955	30	63	population	population	NOUN
aiua-13955	30	64	:	:	PUNCT
aiua-13955	30	65	(	(	PUNCT
aiua-13955	30	66	"	"	PUNCT
aiua-13955	30	67	renal	renal	ADJ
aiua-13955	30	68	cell	cell	NOUN
aiua-13955	30	69	carcinoma	carcinoma	NOUN
aiua-13955	30	70	"	"	PUNCT
aiua-13955	30	71	or	or	CCONJ
aiua-13955	30	72	"	"	PUNCT
aiua-13955	30	73	rcc	rcc	PROPN
aiua-13955	30	74	"	"	PUNCT
aiua-13955	30	75	or	or	CCONJ
aiua-13955	30	76	"	"	PUNCT
aiua-13955	30	77	kidney	kidney	NOUN
aiua-13955	30	78	cancer	cancer	NOUN
aiua-13955	30	79	"	"	PUNCT
aiua-13955	30	80	)	)	PUNCT
aiua-13955	30	81	−	−	PROPN
aiua-13955	30	82	intervention	intervention	NOUN
aiua-13955	30	83	/	/	SYM
aiua-13955	30	84	exposure	exposure	NOUN
aiua-13955	30	85	:	:	PUNCT
aiua-13955	30	86	(	(	PUNCT
aiua-13955	30	87	"	"	PUNCT
aiua-13955	30	88	interleukin-6	interleukin-6	NOUN
aiua-13955	30	89	"	"	PUNCT
aiua-13955	30	90	or	or	CCONJ
aiua-13955	30	91	"	"	PUNCT
aiua-13955	30	92	il-6	il-6	NOUN
aiua-13955	30	93	"	"	PUNCT
aiua-13955	30	94	or	or	CCONJ
aiua-13955	30	95	"	"	PUNCT
aiua-13955	30	96	serum	serum	NOUN
aiua-13955	30	97	cytokine	cytokine	NOUN
aiua-13955	30	98	"	"	PUNCT
aiua-13955	30	99	)	)	PUNCT
aiua-13955	31	1	−	−	PROPN
aiua-13955	32	1	outcome	outcome	NOUN
aiua-13955	32	2	:	:	PUNCT
aiua-13955	32	3	(	(	PUNCT
aiua-13955	32	4	"	"	PUNCT
aiua-13955	32	5	prognosis	prognosis	NOUN
aiua-13955	32	6	"	"	PUNCT
aiua-13955	32	7	or	or	CCONJ
aiua-13955	32	8	"	"	PUNCT
aiua-13955	32	9	survival	survival	NOUN
aiua-13955	32	10	"	"	PUNCT
aiua-13955	32	11	)	)	PUNCT
aiua-13955	32	12	−	−	PROPN
aiua-13955	32	13	study	study	NOUN
aiua-13955	32	14	design	design	NOUN
aiua-13955	32	15	:	:	PUNCT
aiua-13955	32	16	(	(	PUNCT
aiua-13955	32	17	"	"	PUNCT
aiua-13955	32	18	cohort	cohort	NOUN
aiua-13955	32	19	"	"	PUNCT
aiua-13955	32	20	or	or	CCONJ
aiua-13955	32	21	"	"	PUNCT
aiua-13955	32	22	prospective	prospective	ADJ
aiua-13955	32	23	"	"	PUNCT
aiua-13955	32	24	or	or	CCONJ
aiua-13955	32	25	"	"	PUNCT
aiua-13955	32	26	retrospective	retrospective	ADJ
aiua-13955	32	27	"	"	PUNCT
aiua-13955	32	28	)	)	PUNCT
aiua-13955	32	29	.	.	PUNCT
aiua-13955	33	1	the	the	DET
aiua-13955	33	2	search	search	NOUN
aiua-13955	33	3	strategy	strategy	NOUN
aiua-13955	33	4	will	will	AUX
aiua-13955	33	5	combine	combine	VERB
aiua-13955	33	6	mesh	mesh	NOUN
aiua-13955	33	7	terms	term	NOUN
aiua-13955	33	8	and	and	CCONJ
aiua-13955	33	9	freetext	freetext	NOUN
aiua-13955	33	10	keywords	keyword	NOUN
aiua-13955	33	11	with	with	ADP
aiua-13955	33	12	boolean	boolean	ADJ
aiua-13955	33	13	operators	operator	NOUN
aiua-13955	33	14	.	.	PUNCT
aiua-13955	34	1	two	two	NUM
aiua-13955	34	2	independent	independent	ADJ
aiua-13955	34	3	reviewers	reviewer	NOUN
aiua-13955	34	4	will	will	AUX
aiua-13955	34	5	perform	perform	VERB
aiua-13955	34	6	the	the	DET
aiua-13955	34	7	search	search	NOUN
aiua-13955	34	8	,	,	PUNCT
aiua-13955	34	9	remove	remove	VERB
aiua-13955	34	10	duplicates	duplicate	NOUN
aiua-13955	34	11	,	,	PUNCT
aiua-13955	34	12	and	and	CCONJ
aiua-13955	34	13	screen	screen	NOUN
aiua-13955	34	14	titles	title	NOUN
aiua-13955	34	15	/	/	SYM
aiua-13955	34	16	abstracts	abstract	NOUN
aiua-13955	34	17	.	.	PUNCT
aiua-13955	35	1	full	full	ADJ
aiua-13955	35	2	texts	text	NOUN
aiua-13955	35	3	of	of	ADP
aiua-13955	35	4	potentially	potentially	ADV
aiua-13955	35	5	eligible	eligible	ADJ
aiua-13955	35	6	studies	study	NOUN
aiua-13955	35	7	will	will	AUX
aiua-13955	35	8	be	be	AUX
aiua-13955	35	9	assessed	assess	VERB
aiua-13955	35	10	for	for	ADP
aiua-13955	35	11	final	final	ADJ
aiua-13955	35	12	inclusion	inclusion	NOUN
aiua-13955	35	13	,	,	PUNCT
aiua-13955	35	14	with	with	ADP
aiua-13955	35	15	discrepancies	discrepancy	NOUN
aiua-13955	35	16	resolved	resolve	VERB
aiua-13955	35	17	by	by	ADP
aiua-13955	35	18	consensus	consensus	NOUN
aiua-13955	35	19	or	or	CCONJ
aiua-13955	35	20	a	a	DET
aiua-13955	35	21	third	third	ADJ
aiua-13955	35	22	reviewer	reviewer	NOUN
aiua-13955	35	23	.	.	PUNCT
aiua-13955	36	1	data	datum	NOUN
aiua-13955	36	2	analyses	analysis	NOUN
aiua-13955	36	3	extracted	extract	VERB
aiua-13955	36	4	data	datum	NOUN
aiua-13955	36	5	will	will	AUX
aiua-13955	36	6	include	include	VERB
aiua-13955	36	7	:	:	PUNCT
aiua-13955	36	8	(	(	PUNCT
aiua-13955	36	9	1	1	X
aiua-13955	36	10	)	)	PUNCT
aiua-13955	36	11	study	study	NOUN
aiua-13955	36	12	characteristics	characteristic	NOUN
aiua-13955	36	13	(	(	PUNCT
aiua-13955	36	14	author	author	NOUN
aiua-13955	36	15	,	,	PUNCT
aiua-13955	36	16	year	year	NOUN
aiua-13955	36	17	,	,	PUNCT
aiua-13955	36	18	country	country	NOUN
aiua-13955	36	19	,	,	PUNCT
aiua-13955	36	20	design	design	NOUN
aiua-13955	36	21	)	)	PUNCT
aiua-13955	36	22	;	;	PUNCT
aiua-13955	36	23	(	(	PUNCT
aiua-13955	36	24	2	2	X
aiua-13955	36	25	)	)	PUNCT
aiua-13955	36	26	patient	patient	ADJ
aiua-13955	36	27	demographics	demographic	NOUN
aiua-13955	36	28	(	(	PUNCT
aiua-13955	36	29	sample	sample	NOUN
aiua-13955	36	30	size	size	NOUN
aiua-13955	36	31	,	,	PUNCT
aiua-13955	36	32	age	age	NOUN
aiua-13955	36	33	,	,	PUNCT
aiua-13955	36	34	sex	sex	NOUN
aiua-13955	36	35	)	)	PUNCT
aiua-13955	36	36	;	;	PUNCT
aiua-13955	36	37	(	(	PUNCT
aiua-13955	36	38	3	3	X
aiua-13955	36	39	)	)	PUNCT
aiua-13955	36	40	il-6	il-6	NOUN
aiua-13955	36	41	measurement	measurement	NOUN
aiua-13955	36	42	methods	method	NOUN
aiua-13955	36	43	;	;	PUNCT
aiua-13955	36	44	(	(	PUNCT
aiua-13955	36	45	4	4	X
aiua-13955	36	46	)	)	PUNCT
aiua-13955	36	47	clinical	clinical	ADJ
aiua-13955	36	48	outcomes	outcome	NOUN
aiua-13955	37	1	[	[	X
aiua-13955	37	2	os	os	INTJ
aiua-13955	37	3	,	,	PUNCT
aiua-13955	37	4	pfs	pfs	PROPN
aiua-13955	37	5	,	,	PUNCT
aiua-13955	37	6	and	and	CCONJ
aiua-13955	37	7	hr	hr	NOUN
aiua-13955	37	8	with	with	ADP
aiua-13955	37	9	95	95	NUM
aiua-13955	37	10	%	%	NOUN
aiua-13955	37	11	confidence	confidence	NOUN
aiua-13955	37	12	intervals	interval	NOUN
aiua-13955	37	13	(	(	PUNCT
aiua-13955	37	14	cis	cis	NOUN
aiua-13955	37	15	)	)	PUNCT
aiua-13955	37	16	]	]	PUNCT
aiua-13955	37	17	.	.	PUNCT
aiua-13955	38	1	statistical	statistical	ADJ
aiua-13955	38	2	analysis	analysis	NOUN
aiua-13955	38	3	will	will	AUX
aiua-13955	38	4	be	be	AUX
aiua-13955	38	5	performed	perform	VERB
aiua-13955	38	6	using	use	VERB
aiua-13955	38	7	stata	stata	NOUN
aiua-13955	38	8	.	.	PUNCT
aiua-13955	39	1	pooled	pool	VERB
aiua-13955	39	2	os	os	PROPN
aiua-13955	39	3	,	,	PUNCT
aiua-13955	39	4	pfs	pfs	PROPN
aiua-13955	39	5	,	,	PUNCT
aiua-13955	39	6	and	and	CCONJ
aiua-13955	39	7	hr	hr	NOUN
aiua-13955	39	8	will	will	AUX
aiua-13955	39	9	be	be	AUX
aiua-13955	39	10	calculated	calculate	VERB
aiua-13955	39	11	using	use	VERB
aiua-13955	39	12	random	random	ADJ
aiua-13955	39	13	-	-	PUNCT
aiua-13955	39	14	effects	effect	NOUN
aiua-13955	39	15	models	model	NOUN
aiua-13955	39	16	.	.	PUNCT
aiua-13955	40	1	heterogeneity	heterogeneity	NOUN
aiua-13955	40	2	will	will	AUX
aiua-13955	40	3	be	be	AUX
aiua-13955	40	4	assessed	assess	VERB
aiua-13955	40	5	via	via	ADP
aiua-13955	40	6	i²	i²	PROPN
aiua-13955	40	7	statistics	statistic	NOUN
aiua-13955	40	8	(	(	PUNCT
aiua-13955	40	9	i²	i²	NOUN
aiua-13955	40	10	>	>	X
aiua-13955	40	11	50	50	NUM
aiua-13955	40	12	%	%	NOUN
aiua-13955	40	13	indicating	indicate	VERB
aiua-13955	40	14	substantial	substantial	ADJ
aiua-13955	40	15	heterogeneity	heterogeneity	NOUN
aiua-13955	40	16	)	)	PUNCT
aiua-13955	40	17	.	.	PUNCT
aiua-13955	41	1	the	the	DET
aiua-13955	41	2	quality	quality	NOUN
aiua-13955	41	3	of	of	ADP
aiua-13955	41	4	each	each	DET
aiua-13955	41	5	study	study	NOUN
aiua-13955	41	6	assessed	assess	VERB
aiua-13955	41	7	using	use	VERB
aiua-13955	41	8	newcastle	newcastle	PROPN
aiua-13955	41	9	-	-	PUNCT
aiua-13955	41	10	ottawa	ottawa	PROPN
aiua-13955	41	11	scale	scale	NOUN
aiua-13955	41	12	.	.	PUNCT
aiua-13955	42	1	results	result	VERB
aiua-13955	42	2	this	this	DET
aiua-13955	42	3	meta	meta	ADJ
aiua-13955	42	4	-	-	PUNCT
aiua-13955	42	5	analysis	analysis	NOUN
aiua-13955	42	6	incorporated	incorporate	VERB
aiua-13955	42	7	nine	nine	NUM
aiua-13955	42	8	studies	study	NOUN
aiua-13955	42	9	investigating	investigate	VERB
aiua-13955	42	10	the	the	DET
aiua-13955	42	11	prognostic	prognostic	ADJ
aiua-13955	42	12	role	role	NOUN
aiua-13955	42	13	of	of	ADP
aiua-13955	42	14	il-6	il-6	NOUN
aiua-13955	42	15	in	in	ADP
aiua-13955	42	16	renal	renal	ADJ
aiua-13955	42	17	cell	cell	NOUN
aiua-13955	42	18	carcinoma	carcinoma	NOUN
aiua-13955	42	19	(	(	PUNCT
aiua-13955	42	20	rcc	rcc	PROPN
aiua-13955	42	21	)	)	PUNCT
aiua-13955	42	22	,	,	PUNCT
aiua-13955	42	23	comprising	comprise	VERB
aiua-13955	42	24	a	a	DET
aiua-13955	42	25	total	total	NOUN
aiua-13955	42	26	of	of	ADP
aiua-13955	42	27	702	702	NUM
aiua-13955	42	28	patients	patient	NOUN
aiua-13955	42	29	.	.	PUNCT
aiua-13955	43	1	full	full	ADJ
aiua-13955	43	2	search	search	NOUN
aiua-13955	43	3	and	and	CCONJ
aiua-13955	43	4	filter	filter	NOUN
aiua-13955	43	5	details	detail	NOUN
aiua-13955	43	6	are	be	AUX
aiua-13955	43	7	in	in	ADP
aiua-13955	43	8	figure	figure	NOUN
aiua-13955	43	9	1	1	NUM
aiua-13955	43	10	.	.	PUNCT
aiua-13955	44	1	the	the	DET
aiua-13955	44	2	studies	study	NOUN
aiua-13955	44	3	were	be	AUX
aiua-13955	44	4	predominantly	predominantly	ADV
aiua-13955	44	5	retrospective	retrospective	ADJ
aiua-13955	44	6	(	(	PUNCT
aiua-13955	44	7	n	n	NOUN
aiua-13955	44	8	=	=	SYM
aiua-13955	44	9	6	6	NUM
aiua-13955	44	10	)	)	PUNCT
aiua-13955	44	11	,	,	PUNCT
aiua-13955	44	12	with	with	ADP
aiua-13955	44	13	one	one	NUM
aiua-13955	44	14	prospective	prospective	ADJ
aiua-13955	44	15	cohort	cohort	NOUN
aiua-13955	44	16	and	and	CCONJ
aiua-13955	44	17	two	two	NUM
aiua-13955	44	18	clinical	clinical	ADJ
aiua-13955	44	19	trial	trial	NOUN
aiua-13955	44	20	analyses	analysis	NOUN
aiua-13955	44	21	.	.	PUNCT
aiua-13955	45	1	patient	patient	ADJ
aiua-13955	45	2	cohorts	cohort	NOUN
aiua-13955	45	3	varied	varied	ADJ
aiua-13955	45	4	in	in	ADP
aiua-13955	45	5	size	size	NOUN
aiua-13955	45	6	from	from	ADP
aiua-13955	45	7	19	19	NUM
aiua-13955	45	8	to	to	PART
aiua-13955	45	9	217	217	NUM
aiua-13955	45	10	individuals	individual	NOUN
aiua-13955	45	11	,	,	PUNCT
aiua-13955	45	12	with	with	ADP
aiua-13955	45	13	median	median	ADJ
aiua-13955	45	14	/	/	SYM
aiua-13955	45	15	mean	mean	ADJ
aiua-13955	45	16	ages	age	NOUN
aiua-13955	45	17	ranging	range	VERB
aiua-13955	45	18	from	from	ADP
aiua-13955	45	19	55.5	55.5	NUM
aiua-13955	45	20	to	to	PART
aiua-13955	45	21	64.5	64.5	NUM
aiua-13955	45	22	years	year	NOUN
aiua-13955	45	23	where	where	SCONJ
aiua-13955	45	24	reported	report	VERB
aiua-13955	45	25	.	.	PUNCT
aiua-13955	46	1	females	female	NOUN
aiua-13955	46	2	constituted	constitute	VERB
aiua-13955	46	3	32	32	NUM
aiua-13955	46	4	-	-	SYM
aiua-13955	46	5	42	42	NUM
aiua-13955	46	6	%	%	NOUN
aiua-13955	46	7	of	of	ADP
aiua-13955	46	8	participants	participant	NOUN
aiua-13955	46	9	in	in	ADP
aiua-13955	46	10	studies	study	NOUN
aiua-13955	46	11	documenting	document	VERB
aiua-13955	46	12	sex	sex	NOUN
aiua-13955	46	13	distribution	distribution	NOUN
aiua-13955	46	14	.	.	PUNCT
aiua-13955	47	1	most	most	ADJ
aiua-13955	47	2	studies	study	NOUN
aiua-13955	47	3	focused	focus	VERB
aiua-13955	47	4	on	on	ADP
aiua-13955	47	5	metastatic	metastatic	ADJ
aiua-13955	47	6	or	or	CCONJ
aiua-13955	47	7	advanced	advanced	ADJ
aiua-13955	47	8	rcc	rcc	PROPN
aiua-13955	47	9	(	(	PUNCT
aiua-13955	47	10	n	n	NOUN
aiua-13955	47	11	=	=	NOUN
aiua-13955	47	12	7	7	NUM
aiua-13955	47	13	)	)	PUNCT
aiua-13955	47	14	,	,	PUNCT
aiua-13955	47	15	while	while	SCONJ
aiua-13955	47	16	two	two	NUM
aiua-13955	47	17	included	include	VERB
aiua-13955	47	18	localized	localized	ADJ
aiua-13955	47	19	disease	disease	NOUN
aiua-13955	47	20	.	.	PUNCT
aiua-13955	48	1	il-6	il-6	NOUN
aiua-13955	48	2	measurement	measurement	NOUN
aiua-13955	48	3	methods	method	NOUN
aiua-13955	48	4	differed	differ	VERB
aiua-13955	48	5	across	across	ADP
aiua-13955	48	6	studies	study	NOUN
aiua-13955	48	7	:	:	PUNCT
aiua-13955	48	8	two	two	NUM
aiua-13955	48	9	used	use	VERB
aiua-13955	48	10	immunoassay	immunoassay	NOUN
aiua-13955	48	11	(	(	PUNCT
aiua-13955	48	12	without	without	ADP
aiua-13955	48	13	specifying	specify	VERB
aiua-13955	48	14	the	the	DET
aiua-13955	48	15	method	method	NOUN
aiua-13955	48	16	)	)	PUNCT
aiua-13955	48	17	,	,	PUNCT
aiua-13955	48	18	three	three	NUM
aiua-13955	48	19	used	use	VERB
aiua-13955	48	20	serum	serum	NOUN
aiua-13955	48	21	/	/	SYM
aiua-13955	48	22	plasma	plasma	NOUN
aiua-13955	48	23	elisa	elisa	NOUN
aiua-13955	48	24	,	,	PUNCT
aiua-13955	48	25	one	one	NUM
aiua-13955	48	26	used	use	VERB
aiua-13955	48	27	immunoenzymatic	immunoenzymatic	ADJ
aiua-13955	48	28	or	or	CCONJ
aiua-13955	48	29	immunoradiometric	immunoradiometric	ADJ
aiua-13955	48	30	assay	assay	NOUN
aiua-13955	48	31	,	,	PUNCT
aiua-13955	48	32	one	one	NUM
aiua-13955	48	33	used	use	VERB
aiua-13955	48	34	immunohistochemistry	immunohistochemistry	NOUN
aiua-13955	48	35	(	(	PUNCT
aiua-13955	48	36	ihc	ihc	PROPN
aiua-13955	48	37	)	)	PUNCT
aiua-13955	48	38	,	,	PUNCT
aiua-13955	48	39	one	one	NUM
aiua-13955	48	40	directly	directly	ADV
aiua-13955	48	41	measured	measure	VERB
aiua-13955	48	42	the	the	DET
aiua-13955	48	43	level	level	NOUN
aiua-13955	48	44	of	of	ADP
aiua-13955	48	45	il6	il6	NOUN
aiua-13955	48	46	in	in	ADP
aiua-13955	48	47	the	the	DET
aiua-13955	48	48	serum	serum	NOUN
aiua-13955	48	49	,	,	PUNCT
aiua-13955	48	50	and	and	CCONJ
aiua-13955	48	51	one	one	NUM
aiua-13955	48	52	analyzed	analyze	VERB
aiua-13955	48	53	tcga	tcga	PROPN
aiua-13955	48	54	rna	rna	PROPN
aiua-13955	48	55	-	-	PUNCT
aiua-13955	48	56	seq	seq	NOUN
aiua-13955	48	57	data	datum	NOUN
aiua-13955	48	58	.	.	PUNCT
aiua-13955	49	1	cutoffs	cutoff	NOUN
aiua-13955	49	2	for	for	ADP
aiua-13955	49	3	"	"	PUNCT
aiua-13955	49	4	high	high	ADJ
aiua-13955	49	5	il-6	il-6	NOUN
aiua-13955	49	6	"	"	PUNCT
aiua-13955	49	7	were	be	AUX
aiua-13955	49	8	heterogeneous	heterogeneous	ADJ
aiua-13955	49	9	,	,	PUNCT
aiua-13955	49	10	ranging	range	VERB
aiua-13955	49	11	from	from	ADP
aiua-13955	49	12	>	>	X
aiua-13955	49	13	5	5	NUM
aiua-13955	49	14	pg	pg	NOUN
aiua-13955	49	15	/	/	SYM
aiua-13955	49	16	ml	ml	X
aiua-13955	49	17	to	to	PART
aiua-13955	49	18	≥	≥	NOUN
aiua-13955	49	19	35	35	NUM
aiua-13955	49	20	pg	pg	NOUN
aiua-13955	49	21	/	/	SYM
aiua-13955	49	22	ml	ml	X
aiua-13955	49	23	in	in	ADP
aiua-13955	49	24	serum	serum	NOUN
aiua-13955	49	25	assays	assay	NOUN
aiua-13955	49	26	or	or	CCONJ
aiua-13955	49	27	quartile	quartile	NOUN
aiua-13955	49	28	-	-	PUNCT
aiua-13955	49	29	based	base	VERB
aiua-13955	49	30	thresholds	threshold	NOUN
aiua-13955	49	31	in	in	ADP
aiua-13955	49	32	transcriptomic	transcriptomic	ADJ
aiua-13955	49	33	studies	study	NOUN
aiua-13955	49	34	.	.	PUNCT
aiua-13955	50	1	methodological	methodological	ADJ
aiua-13955	50	2	variability	variability	NOUN
aiua-13955	50	3	was	be	AUX
aiua-13955	50	4	evident	evident	ADJ
aiua-13955	50	5	,	,	PUNCT
aiua-13955	50	6	with	with	ADP
aiua-13955	50	7	serum	serum	NOUN
aiua-13955	50	8	/	/	SYM
aiua-13955	50	9	plasma	plasma	NOUN
aiua-13955	50	10	il-6	il-6	NOUN
aiua-13955	50	11	levels	level	NOUN
aiua-13955	50	12	spanning	span	VERB
aiua-13955	50	13	6.9	6.9	NUM
aiua-13955	50	14	-	-	SYM
aiua-13955	50	15	48.2	48.2	NUM
aiua-13955	50	16	pg	pg	NOUN
aiua-13955	50	17	/	/	SYM
aiua-13955	50	18	ml	ml	ADV
aiua-13955	50	19	across	across	ADP
aiua-13955	50	20	cohorts	cohort	NOUN
aiua-13955	50	21	.	.	PUNCT
aiua-13955	51	1	key	key	ADJ
aiua-13955	51	2	findings	finding	NOUN
aiua-13955	51	3	consistently	consistently	ADV
aiua-13955	51	4	associated	associate	VERB
aiua-13955	51	5	elevated	elevate	VERB
aiua-13955	51	6	il-6	il-6	NOUN
aiua-13955	51	7	with	with	ADP
aiua-13955	51	8	adverse	adverse	ADJ
aiua-13955	51	9	outcomes	outcome	NOUN
aiua-13955	51	10	:	:	PUNCT
aiua-13955	51	11	five	five	NUM
aiua-13955	51	12	studies	study	NOUN
aiua-13955	51	13	reported	report	VERB
aiua-13955	51	14	significantly	significantly	ADV
aiua-13955	51	15	worse	bad	ADJ
aiua-13955	51	16	os	os	ADV
aiua-13955	51	17	or	or	CCONJ
aiua-13955	51	18	pfs	pf	VERB
aiua-13955	51	19	with	with	ADP
aiua-13955	51	20	high	high	ADJ
aiua-13955	51	21	il-6	il-6	NUM
aiua-13955	51	22	levels	level	NOUN
aiua-13955	51	23	,	,	PUNCT
aiua-13955	51	24	while	while	SCONJ
aiua-13955	51	25	two	two	NUM
aiua-13955	51	26	noted	note	VERB
aiua-13955	51	27	trends	trend	NOUN
aiua-13955	51	28	toward	toward	ADP
aiua-13955	51	29	poorer	poor	ADJ
aiua-13955	51	30	survival	survival	NOUN
aiua-13955	51	31	.	.	PUNCT
aiua-13955	52	1	despite	despite	SCONJ
aiua-13955	52	2	differing	differ	VERB
aiua-13955	52	3	assays	assay	NOUN
aiua-13955	52	4	and	and	CCONJ
aiua-13955	52	5	cutoffs	cutoff	NOUN
aiua-13955	52	6	,	,	PUNCT
aiua-13955	52	7	all	all	DET
aiua-13955	52	8	studies	study	NOUN
aiua-13955	52	9	supported	support	VERB
aiua-13955	52	10	il-6	il-6	NOUN
aiua-13955	52	11	as	as	ADP
aiua-13955	52	12	a	a	DET
aiua-13955	52	13	negative	negative	ADJ
aiua-13955	52	14	prognostic	prognostic	ADJ
aiua-13955	52	15	marker	marker	NOUN
aiua-13955	52	16	.	.	PUNCT
aiua-13955	53	1	full	full	ADJ
aiua-13955	53	2	study	study	NOUN
aiua-13955	53	3	characteristics	characteristic	NOUN
aiua-13955	53	4	are	be	AUX
aiua-13955	53	5	in	in	ADP
aiua-13955	53	6	table	table	NOUN
aiua-13955	53	7	1	1	NUM
aiua-13955	53	8	.	.	PUNCT
aiua-13955	53	9	figure	figure	NOUN
aiua-13955	53	10	1	1	NUM
aiua-13955	53	11	.	.	PUNCT
aiua-13955	53	12	prisma	prisma	PROPN
aiua-13955	53	13	diagram	diagram	PROPN
aiua-13955	53	14	.	.	PUNCT
aiua-13955	54	1	archivio	archivio	NOUN
aiua-13955	54	2	italiano	italiano	PROPN
aiua-13955	54	3	di	di	PROPN
aiua-13955	54	4	urologia	urologia	PROPN
aiua-13955	54	5	e	e	PROPN
aiua-13955	54	6	andrologia	andrologia	NOUN
aiua-13955	54	7	2025	2025	NUM
aiua-13955	54	8	;	;	PUNCT
aiua-13955	54	9	97(3):13955	97(3):13955	NUM
aiua-13955	54	10	3	3	NUM
aiua-13955	54	11	circulating	circulate	VERB
aiua-13955	54	12	il-6	il-6	NOUN
aiua-13955	54	13	and	and	CCONJ
aiua-13955	54	14	survival	survival	NOUN
aiua-13955	54	15	outcomes	outcome	NOUN
aiua-13955	54	16	in	in	ADP
aiua-13955	54	17	renal	renal	ADJ
aiua-13955	54	18	cell	cell	NOUN
aiua-13955	54	19	carcinoma	carcinoma	NOUN
aiua-13955	54	20	:	:	PUNCT
aiua-13955	54	21	a	a	DET
aiua-13955	54	22	systematic	systematic	ADJ
aiua-13955	54	23	review	review	NOUN
aiua-13955	54	24	and	and	CCONJ
aiua-13955	54	25	meta	meta	ADJ
aiua-13955	54	26	-	-	PUNCT
aiua-13955	54	27	analysis	analysis	NOUN
aiua-13955	54	28	meta	meta	ADJ
aiua-13955	54	29	-	-	PUNCT
aiua-13955	54	30	analysis	analysis	NOUN
aiua-13955	54	31	results	result	NOUN
aiua-13955	54	32	demonstrated	demonstrate	VERB
aiua-13955	54	33	significant	significant	ADJ
aiua-13955	54	34	associations	association	NOUN
aiua-13955	54	35	between	between	ADP
aiua-13955	54	36	il-6	il-6	NOUN
aiua-13955	54	37	levels	level	NOUN
aiua-13955	54	38	and	and	CCONJ
aiua-13955	54	39	survival	survival	NOUN
aiua-13955	54	40	outcomes	outcome	NOUN
aiua-13955	54	41	in	in	ADP
aiua-13955	54	42	rcc	rcc	PROPN
aiua-13955	54	43	patients	patient	NOUN
aiua-13955	54	44	as	as	SCONJ
aiua-13955	54	45	showed	show	VERB
aiua-13955	54	46	in	in	ADP
aiua-13955	54	47	figures	figure	NOUN
aiua-13955	54	48	2	2	NUM
aiua-13955	54	49	-	-	SYM
aiua-13955	54	50	4	4	NUM
aiua-13955	54	51	.	.	PUNCT
aiua-13955	55	1	patients	patient	NOUN
aiua-13955	55	2	with	with	ADP
aiua-13955	55	3	low	low	ADJ
aiua-13955	55	4	il6	il6	PROPN
aiua-13955	55	5	levels	level	NOUN
aiua-13955	55	6	exhibited	exhibit	VERB
aiua-13955	55	7	5.36	5.36	NUM
aiua-13955	55	8	months	month	NOUN
aiua-13955	55	9	longer	long	ADV
aiua-13955	55	10	os	os	ADV
aiua-13955	55	11	compared	compare	VERB
aiua-13955	55	12	to	to	ADP
aiua-13955	55	13	those	those	PRON
aiua-13955	55	14	with	with	ADP
aiua-13955	55	15	high	high	ADJ
aiua-13955	55	16	il-6	il-6	NOUN
aiua-13955	55	17	levels	level	NOUN
aiua-13955	55	18	(	(	PUNCT
aiua-13955	55	19	95	95	NUM
aiua-13955	55	20	%	%	NOUN
aiua-13955	55	21	ci	ci	NOUN
aiua-13955	55	22	:	:	PUNCT
aiua-13955	55	23	2.2	2.2	NUM
aiua-13955	55	24	-	-	SYM
aiua-13955	55	25	8.53	8.53	NUM
aiua-13955	55	26	;	;	PUNCT
aiua-13955	55	27	p	p	X
aiua-13955	55	28	<	<	X
aiua-13955	55	29	0.001	0.001	NUM
aiua-13955	55	30	)	)	PUNCT
aiua-13955	55	31	,	,	PUNCT
aiua-13955	55	32	with	with	ADP
aiua-13955	55	33	no	no	DET
aiua-13955	55	34	observed	observed	ADJ
aiua-13955	55	35	heterogeneity	heterogeneity	NOUN
aiua-13955	55	36	(	(	PUNCT
aiua-13955	55	37	i²	i²	NOUN
aiua-13955	55	38	=	=	PUNCT
aiua-13955	55	39	0	0	NUM
aiua-13955	55	40	%	%	NOUN
aiua-13955	55	41	)	)	PUNCT
aiua-13955	55	42	across	across	ADP
aiua-13955	55	43	all	all	DET
aiua-13955	55	44	nine	nine	NUM
aiua-13955	55	45	studies	study	NOUN
aiua-13955	55	46	.	.	PUNCT
aiua-13955	56	1	similarly	similarly	ADV
aiua-13955	56	2	,	,	PUNCT
aiua-13955	56	3	progression	progression	NOUN
aiua-13955	56	4	-	-	PUNCT
aiua-13955	56	5	free	free	ADJ
aiua-13955	56	6	survival	survival	NOUN
aiua-13955	56	7	(	(	PUNCT
aiua-13955	56	8	pfs	pfs	PROPN
aiua-13955	56	9	)	)	PUNCT
aiua-13955	56	10	was	be	AUX
aiua-13955	56	11	6.41	6.41	NUM
aiua-13955	56	12	months	month	NOUN
aiua-13955	56	13	longer	long	ADV
aiua-13955	56	14	in	in	ADP
aiua-13955	56	15	the	the	DET
aiua-13955	56	16	low	low	ADJ
aiua-13955	56	17	il-6	il-6	NOUN
aiua-13955	56	18	group	group	NOUN
aiua-13955	56	19	(	(	PUNCT
aiua-13955	56	20	95	95	NUM
aiua-13955	56	21	%	%	NOUN
aiua-13955	56	22	ci	ci	NOUN
aiua-13955	56	23	:	:	PUNCT
aiua-13955	56	24	1.3	1.3	NUM
aiua-13955	56	25	-	-	SYM
aiua-13955	56	26	11.53	11.53	NUM
aiua-13955	56	27	;	;	PUNCT
aiua-13955	56	28	p	p	X
aiua-13955	56	29	=	=	NOUN
aiua-13955	56	30	0.01	0.01	NUM
aiua-13955	56	31	)	)	PUNCT
aiua-13955	56	32	,	,	PUNCT
aiua-13955	56	33	though	though	SCONJ
aiua-13955	56	34	moderate	moderate	ADJ
aiua-13955	56	35	heterogeneity	heterogeneity	NOUN
aiua-13955	56	36	was	be	AUX
aiua-13955	56	37	noted	note	VERB
aiua-13955	56	38	(	(	PUNCT
aiua-13955	56	39	i²	i²	NOUN
aiua-13955	56	40	=	=	NOUN
aiua-13955	56	41	48.5	48.5	NUM
aiua-13955	56	42	%	%	NOUN
aiua-13955	56	43	)	)	PUNCT
aiua-13955	56	44	among	among	ADP
aiua-13955	56	45	the	the	DET
aiua-13955	56	46	four	four	NUM
aiua-13955	56	47	studies	study	NOUN
aiua-13955	56	48	analyzed	analyze	VERB
aiua-13955	56	49	.	.	PUNCT
aiua-13955	57	1	figure	figure	NOUN
aiua-13955	57	2	2	2	NUM
aiua-13955	57	3	.	.	PUNCT
aiua-13955	58	1	overall	overall	ADJ
aiua-13955	58	2	survival	survival	NOUN
aiua-13955	58	3	difference	difference	NOUN
aiua-13955	58	4	low	low	ADV
aiua-13955	58	5	vs	vs	ADP
aiua-13955	58	6	high	high	ADJ
aiua-13955	58	7	il-6	il-6	NUM
aiua-13955	58	8	.	.	PUNCT
aiua-13955	58	9	table	table	NOUN
aiua-13955	58	10	1	1	NUM
aiua-13955	58	11	.	.	PUNCT
aiua-13955	58	12	characteristics	characteristic	NOUN
aiua-13955	58	13	of	of	ADP
aiua-13955	58	14	each	each	DET
aiua-13955	58	15	study	study	NOUN
aiua-13955	58	16	.	.	PUNCT
aiua-13955	59	1	first	first	ADJ
aiua-13955	59	2	author	author	NOUN
aiua-13955	59	3	pilskog	pilskog	NOUN
aiua-13955	59	4	et	et	PROPN
aiua-13955	59	5	al	al	PROPN
aiua-13955	59	6	.	.	PROPN
aiua-13955	60	1	(	(	PUNCT
aiua-13955	60	2	8)	8)	NUM
aiua-13955	60	3	negrier	negrier	NOUN
aiua-13955	60	4	et	et	PROPN
aiua-13955	60	5	al	al	PROPN
aiua-13955	60	6	.	.	PROPN
aiua-13955	61	1	(	(	PUNCT
aiua-13955	61	2	9	9	X
aiua-13955	61	3	)	)	PUNCT
aiua-13955	61	4	pilskog	pilskog	NOUN
aiua-13955	61	5	et	et	PROPN
aiua-13955	61	6	al	al	PROPN
aiua-13955	61	7	.	.	PROPN
aiua-13955	62	1	(	(	PUNCT
aiua-13955	62	2	5	5	X
aiua-13955	62	3	)	)	PUNCT
aiua-13955	62	4	tran	tran	NOUN
aiua-13955	62	5	et	et	PROPN
aiua-13955	62	6	al	al	PROPN
aiua-13955	62	7	.	.	PROPN
aiua-13955	63	1	(	(	PUNCT
aiua-13955	63	2	10	10	NUM
aiua-13955	63	3	)	)	PUNCT
aiua-13955	63	4	thiounn	thiounn	NOUN
aiua-13955	63	5	et	et	PROPN
aiua-13955	63	6	al	al	PROPN
aiua-13955	63	7	.	.	PROPN
aiua-13955	64	1	(	(	PUNCT
aiua-13955	64	2	11	11	NUM
aiua-13955	64	3	)	)	PUNCT
aiua-13955	64	4	stadler	stadler	NOUN
aiua-13955	64	5	et	et	PROPN
aiua-13955	64	6	al	al	PROPN
aiua-13955	64	7	.	.	PUNCT
aiua-13955	65	1	(	(	PUNCT
aiua-13955	65	2	12	12	NUM
aiua-13955	65	3	)	)	PUNCT
aiua-13955	65	4	costes	cost	VERB
aiua-13955	65	5	et	et	PROPN
aiua-13955	65	6	al	al	PROPN
aiua-13955	65	7	.	.	PROPN
aiua-13955	66	1	(	(	PUNCT
aiua-13955	66	2	13	13	NUM
aiua-13955	66	3	)	)	PUNCT
aiua-13955	66	4	akdogan	akdogan	NOUN
aiua-13955	66	5	et	et	PROPN
aiua-13955	66	6	al	al	PROPN
aiua-13955	66	7	.	.	PUNCT
aiua-13955	67	1	(	(	PUNCT
aiua-13955	67	2	14	14	X
aiua-13955	67	3	)	)	PUNCT
aiua-13955	67	4	kays	kay	NOUN
aiua-13955	67	5	et	et	PROPN
aiua-13955	67	6	al	al	PROPN
aiua-13955	67	7	.	.	PROPN
aiua-13955	68	1	(	(	PUNCT
aiua-13955	68	2	15	15	NUM
aiua-13955	68	3	)	)	PUNCT
aiua-13955	68	4	country	country	NOUN
aiua-13955	68	5	of	of	ADP
aiua-13955	68	6	study	study	PROPN
aiua-13955	68	7	norway	norway	PROPN
aiua-13955	68	8	france	france	PROPN
aiua-13955	68	9	norway	norway	PROPN
aiua-13955	68	10	usa	usa	PROPN
aiua-13955	68	11	france	france	PROPN
aiua-13955	68	12	argentina	argentina	PROPN
aiua-13955	68	13	france	france	PROPN
aiua-13955	68	14	turkey	turkey	PROPN
aiua-13955	68	15	usa	usa	PROPN
aiua-13955	68	16	study	study	PROPN
aiua-13955	68	17	design	design	VERB
aiua-13955	68	18	open	open	ADJ
aiua-13955	68	19	-	-	PUNCT
aiua-13955	68	20	label	label	NOUN
aiua-13955	68	21	,	,	PUNCT
aiua-13955	68	22	single	single	ADJ
aiua-13955	68	23	-	-	PUNCT
aiua-13955	68	24	arm	arm	NOUN
aiua-13955	68	25	phase	phase	NOUN
aiua-13955	68	26	ii	ii	PROPN
aiua-13955	68	27	study	study	VERB
aiua-13955	68	28	retrospective	retrospective	ADJ
aiua-13955	68	29	analysis	analysis	NOUN
aiua-13955	68	30	of	of	ADP
aiua-13955	68	31	a	a	DET
aiua-13955	68	32	randomized	randomized	ADJ
aiua-13955	68	33	multicentric	multicentric	ADJ
aiua-13955	68	34	trial	trial	NOUN
aiua-13955	68	35	retrospective	retrospective	ADJ
aiua-13955	68	36	analysis	analysis	NOUN
aiua-13955	68	37	of	of	ADP
aiua-13955	68	38	a	a	DET
aiua-13955	68	39	single	single	ADJ
aiua-13955	68	40	-	-	PUNCT
aiua-13955	68	41	arm	arm	NOUN
aiua-13955	68	42	phase	phase	NOUN
aiua-13955	68	43	ii	ii	PROPN
aiua-13955	68	44	study	study	VERB
aiua-13955	68	45	retrospective	retrospective	ADJ
aiua-13955	68	46	analysis	analysis	NOUN
aiua-13955	68	47	of	of	ADP
aiua-13955	68	48	phase	phase	NOUN
aiua-13955	68	49	2	2	NUM
aiua-13955	68	50	and	and	CCONJ
aiua-13955	68	51	phase	phase	NOUN
aiua-13955	68	52	3	3	NUM
aiua-13955	68	53	clinical	clinical	ADJ
aiua-13955	68	54	trials	trial	NOUN
aiua-13955	68	55	retrospective	retrospective	ADJ
aiua-13955	68	56	study	study	NOUN
aiua-13955	68	57	analysis	analysis	NOUN
aiua-13955	68	58	of	of	ADP
aiua-13955	68	59	patients	patient	NOUN
aiua-13955	68	60	in	in	ADP
aiua-13955	68	61	a	a	DET
aiua-13955	68	62	phase	phase	NOUN
aiua-13955	68	63	i	i	PRON
aiua-13955	68	64	evaluation	evaluation	VERB
aiua-13955	68	65	retrospective	retrospective	ADJ
aiua-13955	68	66	analysis	analysis	NOUN
aiua-13955	68	67	prospective	prospective	ADJ
aiua-13955	68	68	observational	observational	ADJ
aiua-13955	68	69	cohort	cohort	NOUN
aiua-13955	68	70	study	study	NOUN
aiua-13955	68	71	retrospective	retrospective	ADJ
aiua-13955	68	72	analysis	analysis	NOUN
aiua-13955	68	73	of	of	ADP
aiua-13955	68	74	tcga	tcga	PROPN
aiua-13955	68	75	data	datum	NOUN
aiua-13955	68	76	total	total	ADJ
aiua-13955	68	77	number	number	NOUN
aiua-13955	68	78	of	of	ADP
aiua-13955	68	79	patients	patient	NOUN
aiua-13955	68	80	46	46	NUM
aiua-13955	68	81	138	138	NUM
aiua-13955	68	82	46	46	NUM
aiua-13955	68	83	129	129	NUM
aiua-13955	68	84	19	19	NUM
aiua-13955	68	85	22	22	NUM
aiua-13955	68	86	38	38	NUM
aiua-13955	68	87	23	23	NUM
aiua-13955	68	88	(	(	PUNCT
aiua-13955	68	89	rcc	rcc	PROPN
aiua-13955	68	90	subgroup	subgroup	NOUN
aiua-13955	68	91	of	of	ADP
aiua-13955	68	92	85	85	NUM
aiua-13955	68	93	total	total	ADJ
aiua-13955	68	94	cancer	cancer	NOUN
aiua-13955	68	95	patients	patient	NOUN
aiua-13955	68	96	)	)	PUNCT
aiua-13955	68	97	217	217	NUM
aiua-13955	68	98	(	(	PUNCT
aiua-13955	68	99	ccrcc	ccrcc	NOUN
aiua-13955	68	100	)	)	PUNCT
aiua-13955	68	101	average	average	ADJ
aiua-13955	68	102	age	age	NOUN
aiua-13955	68	103	median	median	NOUN
aiua-13955	68	104	63.1	63.1	NUM
aiua-13955	68	105	years	year	NOUN
aiua-13955	68	106	median	median	NOUN
aiua-13955	68	107	56	56	NUM
aiua-13955	68	108	years	year	NOUN
aiua-13955	68	109	median	median	PROPN
aiua-13955	68	110	63.1	63.1	NUM
aiua-13955	68	111	years	year	NOUN
aiua-13955	68	112	not	not	PART
aiua-13955	68	113	stated	state	VERB
aiua-13955	68	114	mean	mean	NOUN
aiua-13955	68	115	55.5	55.5	NUM
aiua-13955	68	116	years	year	NOUN
aiua-13955	68	117	not	not	PART
aiua-13955	68	118	stated	state	VERB
aiua-13955	68	119	61.2	61.2	NUM
aiua-13955	68	120	years	year	NOUN
aiua-13955	68	121	median	median	NOUN
aiua-13955	68	122	64.5	64.5	NUM
aiua-13955	68	123	years	year	NOUN
aiua-13955	68	124	(	(	PUNCT
aiua-13955	68	125	overall	overall	ADJ
aiua-13955	68	126	cohort	cohort	NOUN
aiua-13955	68	127	)	)	PUNCT
aiua-13955	68	128	59.65	59.65	NUM
aiua-13955	68	129	years	year	NOUN
aiua-13955	68	130	percentage	percentage	NOUN
aiua-13955	68	131	of	of	ADP
aiua-13955	68	132	women	woman	NOUN
aiua-13955	68	133	37.0	37.0	NUM
aiua-13955	68	134	%	%	NOUN
aiua-13955	68	135	28.3	28.3	NUM
aiua-13955	68	136	%	%	NOUN
aiua-13955	68	137	37.0	37.0	NUM
aiua-13955	68	138	%	%	NOUN
aiua-13955	68	139	not	not	PART
aiua-13955	68	140	stated	state	VERB
aiua-13955	68	141	42.1	42.1	NUM
aiua-13955	68	142	%	%	NOUN
aiua-13955	68	143	not	not	PART
aiua-13955	68	144	stated	state	VERB
aiua-13955	68	145	28.9	28.9	NUM
aiua-13955	68	146	%	%	NOUN
aiua-13955	68	147	32	32	NUM
aiua-13955	68	148	%	%	NOUN
aiua-13955	68	149	(	(	PUNCT
aiua-13955	68	150	overall	overall	ADJ
aiua-13955	68	151	cohort	cohort	NOUN
aiua-13955	68	152	)	)	PUNCT
aiua-13955	68	153	not	not	PART
aiua-13955	68	154	stated	state	VERB
aiua-13955	68	155	cancer	cancer	NOUN
aiua-13955	68	156	stage	stage	NOUN
aiua-13955	68	157	metastatic	metastatic	ADJ
aiua-13955	68	158	or	or	CCONJ
aiua-13955	68	159	non	non	ADJ
aiua-13955	68	160	-	-	ADJ
aiua-13955	68	161	resectable	resectable	ADJ
aiua-13955	68	162	clear	clear	ADJ
aiua-13955	68	163	cell	cell	NOUN
aiua-13955	68	164	renal	renal	ADJ
aiua-13955	68	165	cell	cell	NOUN
aiua-13955	68	166	carcinoma	carcinoma	NOUN
aiua-13955	68	167	(	(	PUNCT
aiua-13955	68	168	ccrcc	ccrcc	NOUN
aiua-13955	68	169	)	)	PUNCT
aiua-13955	68	170	metastatic	metastatic	ADJ
aiua-13955	68	171	renal	renal	ADJ
aiua-13955	68	172	cell	cell	NOUN
aiua-13955	68	173	carcinoma	carcinoma	NOUN
aiua-13955	68	174	(	(	PUNCT
aiua-13955	68	175	mrcc	mrcc	NOUN
aiua-13955	68	176	)	)	PUNCT
aiua-13955	68	177	metastatic	metastatic	ADJ
aiua-13955	68	178	or	or	CCONJ
aiua-13955	68	179	non	non	ADJ
aiua-13955	68	180	-	-	ADJ
aiua-13955	68	181	resectable	resectable	ADJ
aiua-13955	68	182	clear	clear	ADJ
aiua-13955	68	183	cell	cell	NOUN
aiua-13955	68	184	renal	renal	ADJ
aiua-13955	68	185	cell	cell	NOUN
aiua-13955	68	186	carcinoma	carcinoma	NOUN
aiua-13955	68	187	(	(	PUNCT
aiua-13955	68	188	ccrcc	ccrcc	NOUN
aiua-13955	68	189	)	)	PUNCT
aiua-13955	68	190	metastatic	metastatic	ADJ
aiua-13955	68	191	renal	renal	ADJ
aiua-13955	68	192	-	-	PUNCT
aiua-13955	68	193	cell	cell	NOUN
aiua-13955	68	194	carcinoma	carcinoma	NOUN
aiua-13955	68	195	metastatic	metastatic	ADJ
aiua-13955	68	196	renal	renal	ADJ
aiua-13955	68	197	cell	cell	NOUN
aiua-13955	68	198	carcinoma	carcinoma	NOUN
aiua-13955	68	199	metastatic	metastatic	ADJ
aiua-13955	68	200	kidney	kidney	NOUN
aiua-13955	68	201	cancer	cancer	NOUN
aiua-13955	68	202	primary	primary	ADJ
aiua-13955	68	203	renal	renal	ADJ
aiua-13955	68	204	cell	cell	NOUN
aiua-13955	68	205	carcinoma	carcinoma	NOUN
aiua-13955	68	206	(	(	PUNCT
aiua-13955	68	207	stages	stage	NOUN
aiua-13955	68	208	i	i	NOUN
aiua-13955	68	209	-	-	PUNCT
aiua-13955	68	210	iv	iv	X
aiua-13955	68	211	)	)	PUNCT
aiua-13955	68	212	advanced	advanced	ADJ
aiua-13955	68	213	renal	renal	ADJ
aiua-13955	68	214	cell	cell	NOUN
aiua-13955	68	215	carcinoma	carcinoma	NOUN
aiua-13955	68	216	(	(	PUNCT
aiua-13955	68	217	part	part	NOUN
aiua-13955	68	218	of	of	ADP
aiua-13955	68	219	a	a	DET
aiua-13955	68	220	cohort	cohort	NOUN
aiua-13955	68	221	with	with	ADP
aiua-13955	68	222	nsclc	nsclc	NOUN
aiua-13955	68	223	and	and	CCONJ
aiua-13955	68	224	melanoma	melanoma	NOUN
aiua-13955	68	225	)	)	PUNCT
aiua-13955	68	226	clear	clear	ADJ
aiua-13955	68	227	cell	cell	NOUN
aiua-13955	68	228	renal	renal	ADJ
aiua-13955	68	229	cell	cell	NOUN
aiua-13955	68	230	carcinoma	carcinoma	NOUN
aiua-13955	68	231	(	(	PUNCT
aiua-13955	68	232	ccrcc	ccrcc	NOUN
aiua-13955	68	233	)	)	PUNCT
aiua-13955	68	234	il-6	il-6	NOUN
aiua-13955	69	1	detection	detection	NOUN
aiua-13955	69	2	method	method	NOUN
aiua-13955	69	3	elisa	elisa	NOUN
aiua-13955	69	4	(	(	PUNCT
aiua-13955	69	5	plasma	plasma	NOUN
aiua-13955	69	6	il-6	il-6	NOUN
aiua-13955	69	7	pil6	pil6	PROPN
aiua-13955	69	8	)	)	PUNCT
aiua-13955	69	9	immunoassay	immunoassay	PROPN
aiua-13955	69	10	(	(	PUNCT
aiua-13955	69	11	serum	serum	PROPN
aiua-13955	69	12	il-6	il-6	NOUN
aiua-13955	69	13	)	)	PUNCT
aiua-13955	69	14	immunohistochemistry	immunohistochemistry	NOUN
aiua-13955	69	15	(	(	PUNCT
aiua-13955	69	16	ihc	ihc	PROPN
aiua-13955	69	17	)	)	PUNCT
aiua-13955	69	18	(	(	PUNCT
aiua-13955	69	19	tumour	tumour	NOUN
aiua-13955	69	20	tissue	tissue	NOUN
aiua-13955	69	21	il-6	il-6	NOUN
aiua-13955	69	22	expression	expression	NOUN
aiua-13955	69	23	)	)	PUNCT
aiua-13955	69	24	multiplex	multiplex	PROPN
aiua-13955	69	25	assay	assay	PROPN
aiua-13955	69	26	,	,	PUNCT
aiua-13955	69	27	protein	protein	NOUN
aiua-13955	69	28	array	array	NOUN
aiua-13955	69	29	,	,	PUNCT
aiua-13955	69	30	and	and	CCONJ
aiua-13955	69	31	elisa	elisa	NOUN
aiua-13955	69	32	(	(	PUNCT
aiua-13955	69	33	plasma	plasma	NOUN
aiua-13955	69	34	il-6	il-6	NOUN
aiua-13955	69	35	)	)	PUNCT
aiua-13955	69	36	assay	assay	PROPN
aiua-13955	69	37	(	(	PUNCT
aiua-13955	69	38	serum	serum	NOUN
aiua-13955	69	39	il-6	il-6	NOUN
aiua-13955	69	40	)	)	PUNCT
aiua-13955	69	41	measured	measure	VERB
aiua-13955	69	42	levels	level	NOUN
aiua-13955	69	43	of	of	ADP
aiua-13955	69	44	il-6	il-6	NOUN
aiua-13955	69	45	in	in	ADP
aiua-13955	69	46	serum	serum	NOUN
aiua-13955	69	47	immunoenzymatic	immunoenzymatic	ADJ
aiua-13955	69	48	or	or	CCONJ
aiua-13955	69	49	immunoradiometric	immunoradiometric	ADJ
aiua-13955	69	50	assay	assay	NOUN
aiua-13955	69	51	(	(	PUNCT
aiua-13955	69	52	serum	serum	NOUN
aiua-13955	69	53	il-6	il-6	NOUN
aiua-13955	69	54	)	)	PUNCT
aiua-13955	69	55	elisa	elisa	NOUN
aiua-13955	69	56	(	(	PUNCT
aiua-13955	69	57	baseline	baseline	VERB
aiua-13955	69	58	serum	serum	PROPN
aiua-13955	69	59	il-6	il-6	NOUN
aiua-13955	69	60	)	)	PUNCT
aiua-13955	69	61	rnaseq	rnaseq	NOUN
aiua-13955	69	62	(	(	PUNCT
aiua-13955	69	63	tumour	tumour	NOUN
aiua-13955	69	64	il-6	il-6	NOUN
aiua-13955	69	65	gene	gene	NOUN
aiua-13955	69	66	expression	expression	NOUN
aiua-13955	69	67	)	)	PUNCT
aiua-13955	69	68	il-6	il-6	NOUN
aiua-13955	70	1	cutoff	cutoff	NOUN
aiua-13955	70	2	(	(	PUNCT
aiua-13955	70	3	high	high	ADJ
aiua-13955	70	4	/	/	SYM
aiua-13955	70	5	low	low	ADJ
aiua-13955	70	6	)	)	PUNCT
aiua-13955	70	7	low	low	ADJ
aiua-13955	70	8	pil6	pil6	NOUN
aiua-13955	70	9	at	at	ADP
aiua-13955	70	10	baseline	baseline	PROPN
aiua-13955	70	11	associated	associate	VERB
aiua-13955	70	12	with	with	ADP
aiua-13955	70	13	improved	improved	ADJ
aiua-13955	70	14	response	response	NOUN
aiua-13955	70	15	and	and	CCONJ
aiua-13955	70	16	pfs	pfs	PROPN
aiua-13955	70	17	;	;	PUNCT
aiua-13955	70	18	median	median	ADJ
aiua-13955	70	19	baseline	baseline	PROPN
aiua-13955	70	20	pil6	pil6	PROPN
aiua-13955	70	21	was	be	AUX
aiua-13955	70	22	6.90	6.90	NUM
aiua-13955	70	23	pg	pg	NOUN
aiua-13955	70	24	/	/	SYM
aiua-13955	70	25	ml	ml	PROPN
aiua-13955	70	26	(	(	PUNCT
aiua-13955	70	27	implied	imply	VERB
aiua-13955	70	28	cutoff	cutoff	NOUN
aiua-13955	70	29	around	around	ADP
aiua-13955	70	30	this	this	DET
aiua-13955	70	31	value	value	NOUN
aiua-13955	70	32	)	)	PUNCT
aiua-13955	70	33	high	high	ADJ
aiua-13955	70	34	il-6	il-6	NOUN
aiua-13955	71	1	(	(	PUNCT
aiua-13955	71	2	≥	≥	NUM
aiua-13955	71	3	35	35	NUM
aiua-13955	71	4	pg	pg	NOUN
aiua-13955	71	5	/	/	SYM
aiua-13955	71	6	ml	ml	VERB
aiua-13955	71	7	)	)	PUNCT
aiua-13955	71	8	associated	associate	VERB
aiua-13955	71	9	with	with	ADP
aiua-13955	71	10	worse	bad	ADJ
aiua-13955	71	11	overall	overall	ADJ
aiua-13955	71	12	survival	survival	NOUN
aiua-13955	71	13	(	(	PUNCT
aiua-13955	71	14	cutoff	cutoff	NOUN
aiua-13955	71	15	determined	determine	VERB
aiua-13955	71	16	by	by	ADP
aiua-13955	71	17	quartile	quartile	ADJ
aiua-13955	71	18	method	method	NOUN
aiua-13955	71	19	)	)	PUNCT
aiua-13955	71	20	low	low	ADJ
aiua-13955	71	21	vs.	vs.	ADP
aiua-13955	71	22	high	high	ADJ
aiua-13955	71	23	expression	expression	NOUN
aiua-13955	71	24	in	in	ADP
aiua-13955	71	25	tumour	tumour	NOUN
aiua-13955	71	26	cells	cell	NOUN
aiua-13955	71	27	based	base	VERB
aiua-13955	71	28	on	on	ADP
aiua-13955	71	29	staining	stain	VERB
aiua-13955	71	30	index	index	NOUN
aiua-13955	71	31	(	(	PUNCT
aiua-13955	71	32	si	si	NOUN
aiua-13955	71	33	0	0	NUM
aiua-13955	71	34	-	-	SYM
aiua-13955	71	35	2	2	NUM
aiua-13955	71	36	vs	vs	ADP
aiua-13955	71	37	3	3	NUM
aiua-13955	71	38	-	-	SYM
aiua-13955	71	39	9	9	NUM
aiua-13955	71	40	)	)	PUNCT
aiua-13955	71	41	,	,	PUNCT
aiua-13955	71	42	low	low	ADJ
aiua-13955	71	43	expression	expression	NOUN
aiua-13955	71	44	associated	associate	VERB
aiua-13955	71	45	with	with	ADP
aiua-13955	71	46	improved	improved	ADJ
aiua-13955	71	47	pfs	pfs	ADV
aiua-13955	71	48	low	low	ADJ
aiua-13955	71	49	(	(	PUNCT
aiua-13955	71	50	relative	relative	ADJ
aiua-13955	71	51	to	to	ADP
aiua-13955	71	52	median	median	ADJ
aiua-13955	71	53	)	)	PUNCT
aiua-13955	71	54	il-6	il-6	NOUN
aiua-13955	71	55	correlated	correlate	VERB
aiua-13955	71	56	with	with	ADP
aiua-13955	71	57	increased	increase	VERB
aiua-13955	71	58	tumour	tumour	NOUN
aiua-13955	71	59	shrinkage	shrinkage	NOUN
aiua-13955	71	60	and	and	CCONJ
aiua-13955	71	61	prolonged	prolonged	ADJ
aiua-13955	71	62	pfs	pfs	PROPN
aiua-13955	71	63	;	;	PUNCT
aiua-13955	71	64	high	high	ADJ
aiua-13955	71	65	levels	level	NOUN
aiua-13955	71	66	were	be	AUX
aiua-13955	71	67	negative	negative	ADJ
aiua-13955	71	68	prognostic	prognostic	ADJ
aiua-13955	71	69	factors	factor	NOUN
aiua-13955	71	70	(	(	PUNCT
aiua-13955	71	71	median	median	NOUN
aiua-13955	71	72	not	not	PART
aiua-13955	71	73	specified	specify	VERB
aiua-13955	71	74	in	in	ADP
aiua-13955	71	75	excerpt	excerpt	NOUN
aiua-13955	71	76	)	)	PUNCT
aiua-13955	71	77	greater	great	ADJ
aiua-13955	71	78	or	or	CCONJ
aiua-13955	71	79	less	less	ADJ
aiua-13955	71	80	than	than	ADP
aiua-13955	71	81	15	15	NUM
aiua-13955	71	82	pg	pg	NOUN
aiua-13955	71	83	/	/	SYM
aiua-13955	71	84	ml	ml	NOUN
aiua-13955	71	85	;	;	PUNCT
aiua-13955	71	86	high	high	ADJ
aiua-13955	71	87	il-6	il-6	NOUN
aiua-13955	71	88	correlated	correlate	VERB
aiua-13955	71	89	with	with	ADP
aiua-13955	71	90	shorter	short	ADJ
aiua-13955	71	91	survival	survival	NOUN
aiua-13955	71	92	abnormal	abnormal	ADJ
aiua-13955	71	93	il-6	il-6	NOUN
aiua-13955	72	1	(	(	PUNCT
aiua-13955	72	2	>	>	SYM
aiua-13955	72	3	5	5	NUM
aiua-13955	72	4	pg	pg	NOUN
aiua-13955	72	5	/	/	SYM
aiua-13955	72	6	ml	ml	VERB
aiua-13955	72	7	)	)	PUNCT
aiua-13955	72	8	associated	associate	VERB
aiua-13955	72	9	with	with	ADP
aiua-13955	72	10	worse	bad	ADJ
aiua-13955	72	11	prognosis	prognosis	NOUN
aiua-13955	72	12	detectable	detectable	ADJ
aiua-13955	72	13	serum	serum	NOUN
aiua-13955	72	14	il-6	il-6	NOUN
aiua-13955	73	1	(	(	PUNCT
aiua-13955	73	2	presence	presence	NOUN
aiua-13955	73	3	vs.	vs.	ADP
aiua-13955	73	4	absence	absence	NOUN
aiua-13955	73	5	)	)	PUNCT
aiua-13955	73	6	correlated	correlate	VERB
aiua-13955	73	7	with	with	ADP
aiua-13955	73	8	worse	bad	ADJ
aiua-13955	73	9	survival	survival	NOUN
aiua-13955	73	10	;	;	PUNCT
aiua-13955	73	11	mean	mean	VERB
aiua-13955	73	12	serum	serum	PROPN
aiua-13955	73	13	il-6	il-6	NUM
aiua-13955	73	14	was	be	AUX
aiua-13955	73	15	8.32	8.32	NUM
aiua-13955	73	16	pg	pg	NOUN
aiua-13955	73	17	/	/	SYM
aiua-13955	73	18	ml	ml	X
aiua-13955	73	19	in	in	ADP
aiua-13955	73	20	il-6r	il-6r	ADJ
aiua-13955	73	21	-ve	-ve	NOUN
aiua-13955	73	22	and	and	CCONJ
aiua-13955	73	23	48.2	48.2	NUM
aiua-13955	73	24	pg	pg	NOUN
aiua-13955	73	25	/	/	SYM
aiua-13955	73	26	ml	ml	VERB
aiua-13955	73	27	in	in	ADP
aiua-13955	73	28	il-6r	il-6r	PROPN
aiua-13955	73	29	+	+	PROPN
aiua-13955	73	30	ve	ve	VERB
aiua-13955	73	31	tumours	tumour	NOUN
aiua-13955	73	32	stratified	stratify	VERB
aiua-13955	73	33	by	by	ADP
aiua-13955	73	34	median	median	PROPN
aiua-13955	73	35	il-6	il-6	NUM
aiua-13955	73	36	level	level	NOUN
aiua-13955	73	37	(	(	PUNCT
aiua-13955	73	38	20.0	20.0	NUM
aiua-13955	73	39	pg	pg	NOUN
aiua-13955	73	40	/	/	SYM
aiua-13955	73	41	ml	ml	NOUN
aiua-13955	73	42	)	)	PUNCT
aiua-13955	73	43	;	;	PUNCT
aiua-13955	73	44	higher	high	ADJ
aiua-13955	73	45	levels	level	NOUN
aiua-13955	73	46	showed	show	VERB
aiua-13955	73	47	a	a	DET
aiua-13955	73	48	trend	trend	NOUN
aiua-13955	73	49	towards	towards	ADP
aiua-13955	73	50	shorter	short	ADJ
aiua-13955	73	51	os	os	NOUN
aiua-13955	73	52	(	(	PUNCT
aiua-13955	73	53	not	not	PART
aiua-13955	73	54	statistically	statistically	ADV
aiua-13955	73	55	significant	significant	ADJ
aiua-13955	73	56	)	)	PUNCT
aiua-13955	73	57	high	high	ADJ
aiua-13955	73	58	vs.	vs.	ADP
aiua-13955	73	59	low	low	ADJ
aiua-13955	73	60	il-6	il-6	NOUN
aiua-13955	73	61	expression	expression	NOUN
aiua-13955	73	62	in	in	ADP
aiua-13955	73	63	tumour	tumour	NOUN
aiua-13955	73	64	,	,	PUNCT
aiua-13955	73	65	correlated	correlate	VERB
aiua-13955	73	66	with	with	ADP
aiua-13955	73	67	survival	survival	NOUN
aiua-13955	73	68	based	base	VERB
aiua-13955	73	69	on	on	ADP
aiua-13955	73	70	quartiles	quartile	NOUN
aiua-13955	73	71	of	of	ADP
aiua-13955	73	72	expression	expression	NOUN
aiua-13955	73	73	;	;	PUNCT
aiua-13955	73	74	high	high	ADJ
aiua-13955	73	75	expression	expression	NOUN
aiua-13955	73	76	associated	associate	VERB
aiua-13955	73	77	with	with	ADP
aiua-13955	73	78	decreased	decrease	VERB
aiua-13955	73	79	survival	survival	NOUN
aiua-13955	73	80	archivio	archivio	PROPN
aiua-13955	73	81	italiano	italiano	PROPN
aiua-13955	73	82	di	di	X
aiua-13955	73	83	urologia	urologia	PROPN
aiua-13955	73	84	e	e	PROPN
aiua-13955	73	85	andrologia	andrologia	NOUN
aiua-13955	73	86	2025	2025	NUM
aiua-13955	73	87	;	;	PUNCT
aiua-13955	73	88	97(3):13955	97(3):13955	NUM
aiua-13955	73	89	h.	h.	NOUN
aiua-13955	73	90	nindito	nindito	PROPN
aiua-13955	73	91	wicaksono	wicaksono	PROPN
aiua-13955	73	92	,	,	PUNCT
aiua-13955	73	93	t.	t.	PROPN
aiua-13955	73	94	nur	nur	PROPN
aiua-13955	73	95	budaya	budaya	PROPN
aiua-13955	73	96	,	,	PUNCT
aiua-13955	73	97	k.	k.	PROPN
aiua-13955	73	98	penta	penta	PROPN
aiua-13955	73	99	seputra	seputra	PROPN
aiua-13955	73	100	,	,	PUNCT
aiua-13955	73	101	a.	a.	PROPN
aiua-13955	73	102	rahman	rahman	PROPN
aiua-13955	73	103	putra	putra	PROPN
aiua-13955	73	104	4	4	NUM
aiua-13955	73	105	the	the	DET
aiua-13955	73	106	pooled	pool	VERB
aiua-13955	73	107	hazard	hazard	NOUN
aiua-13955	73	108	ratio	ratio	NOUN
aiua-13955	73	109	(	(	PUNCT
aiua-13955	73	110	hr	hr	NOUN
aiua-13955	73	111	)	)	PUNCT
aiua-13955	73	112	for	for	ADP
aiua-13955	73	113	survival	survival	NOUN
aiua-13955	73	114	further	far	ADV
aiua-13955	73	115	supported	support	VERB
aiua-13955	73	116	these	these	DET
aiua-13955	73	117	findings	finding	NOUN
aiua-13955	73	118	,	,	PUNCT
aiua-13955	73	119	with	with	ADP
aiua-13955	73	120	high	high	ADJ
aiua-13955	73	121	il-6	il-6	NOUN
aiua-13955	73	122	levels	level	NOUN
aiua-13955	73	123	correlating	correlate	VERB
aiua-13955	73	124	with	with	ADP
aiua-13955	73	125	a	a	DET
aiua-13955	73	126	2.06	2.06	NUM
aiua-13955	73	127	-	-	ADJ
aiua-13955	73	128	fold	fold	ADJ
aiua-13955	73	129	increased	increased	ADJ
aiua-13955	73	130	risk	risk	NOUN
aiua-13955	73	131	of	of	ADP
aiua-13955	73	132	poor	poor	ADJ
aiua-13955	73	133	outcomes	outcome	NOUN
aiua-13955	73	134	(	(	PUNCT
aiua-13955	73	135	95	95	NUM
aiua-13955	73	136	%	%	NOUN
aiua-13955	73	137	ci	ci	NOUN
aiua-13955	73	138	:	:	PUNCT
aiua-13955	73	139	-0.23	-0.23	NUM
aiua-13955	73	140	-	-	PUNCT
aiua-13955	73	141	4.36	4.36	NUM
aiua-13955	73	142	)	)	PUNCT
aiua-13955	73	143	,	,	PUNCT
aiua-13955	73	144	albeit	albeit	SCONJ
aiua-13955	73	145	with	with	ADP
aiua-13955	73	146	substantial	substantial	ADJ
aiua-13955	73	147	heterogeneity	heterogeneity	NOUN
aiua-13955	73	148	(	(	PUNCT
aiua-13955	73	149	i²	i²	NOUN
aiua-13955	73	150	=	=	PUNCT
aiua-13955	73	151	89.19	89.19	NUM
aiua-13955	73	152	%	%	NOUN
aiua-13955	73	153	)	)	PUNCT
aiua-13955	73	154	and	and	CCONJ
aiua-13955	73	155	borderline	borderline	ADJ
aiua-13955	73	156	statistical	statistical	ADJ
aiua-13955	73	157	significance	significance	NOUN
aiua-13955	73	158	(	(	PUNCT
aiua-13955	73	159	p	p	NOUN
aiua-13955	73	160	=	=	NOUN
aiua-13955	73	161	0.08	0.08	NUM
aiua-13955	73	162	)	)	PUNCT
aiua-13955	73	163	.	.	PUNCT
aiua-13955	74	1	these	these	DET
aiua-13955	74	2	results	result	NOUN
aiua-13955	74	3	collectively	collectively	ADV
aiua-13955	74	4	underscore	underscore	VERB
aiua-13955	74	5	il-6	il-6	NOUN
aiua-13955	74	6	as	as	ADP
aiua-13955	74	7	a	a	DET
aiua-13955	74	8	robust	robust	ADJ
aiua-13955	74	9	prognostic	prognostic	ADJ
aiua-13955	74	10	biomarker	biomarker	NOUN
aiua-13955	74	11	in	in	ADP
aiua-13955	74	12	rcc	rcc	PROPN
aiua-13955	74	13	,	,	PUNCT
aiua-13955	74	14	where	where	SCONJ
aiua-13955	74	15	elevated	elevated	ADJ
aiua-13955	74	16	levels	level	NOUN
aiua-13955	74	17	consistently	consistently	ADV
aiua-13955	74	18	predict	predict	VERB
aiua-13955	74	19	shorter	short	ADJ
aiua-13955	74	20	survival	survival	NOUN
aiua-13955	74	21	and	and	CCONJ
aiua-13955	74	22	disease	disease	NOUN
aiua-13955	74	23	progression	progression	NOUN
aiua-13955	74	24	,	,	PUNCT
aiua-13955	74	25	despite	despite	SCONJ
aiua-13955	74	26	variability	variability	NOUN
aiua-13955	74	27	in	in	ADP
aiua-13955	74	28	study	study	NOUN
aiua-13955	74	29	methodologies	methodology	NOUN
aiua-13955	74	30	.	.	PUNCT
aiua-13955	75	1	discussion	discussion	NOUN
aiua-13955	75	2	the	the	DET
aiua-13955	75	3	present	present	ADJ
aiua-13955	75	4	meta	meta	ADJ
aiua-13955	75	5	-	-	PUNCT
aiua-13955	75	6	analysis	analysis	NOUN
aiua-13955	75	7	,	,	PUNCT
aiua-13955	75	8	comprising	comprise	VERB
aiua-13955	75	9	nine	nine	NUM
aiua-13955	75	10	studies	study	NOUN
aiua-13955	75	11	and	and	CCONJ
aiua-13955	75	12	a	a	DET
aiua-13955	75	13	total	total	NOUN
aiua-13955	75	14	of	of	ADP
aiua-13955	75	15	702	702	NUM
aiua-13955	75	16	patients	patient	NOUN
aiua-13955	75	17	with	with	ADP
aiua-13955	75	18	rcc	rcc	PROPN
aiua-13955	75	19	,	,	PUNCT
aiua-13955	75	20	consolidates	consolidate	VERB
aiua-13955	75	21	robust	robust	ADJ
aiua-13955	75	22	evidence	evidence	NOUN
aiua-13955	75	23	that	that	SCONJ
aiua-13955	75	24	elevated	elevated	ADJ
aiua-13955	75	25	il-6	il-6	NOUN
aiua-13955	75	26	levels	level	NOUN
aiua-13955	75	27	are	be	AUX
aiua-13955	75	28	significantly	significantly	ADV
aiua-13955	75	29	associated	associate	VERB
aiua-13955	75	30	with	with	ADP
aiua-13955	75	31	poorer	poor	ADJ
aiua-13955	75	32	survival	survival	NOUN
aiua-13955	75	33	outcomes	outcome	NOUN
aiua-13955	75	34	.	.	PUNCT
aiua-13955	76	1	this	this	DET
aiua-13955	76	2	finding	finding	NOUN
aiua-13955	76	3	aligns	align	VERB
aiua-13955	76	4	with	with	ADP
aiua-13955	76	5	prior	prior	ADJ
aiua-13955	76	6	review	review	NOUN
aiua-13955	76	7	by	by	ADP
aiua-13955	76	8	wang	wang	PROPN
aiua-13955	76	9	et	et	PROPN
aiua-13955	76	10	al	al	PROPN
aiua-13955	76	11	.	.	PROPN
aiua-13955	77	1	(	(	PUNCT
aiua-13955	77	2	2019	2019	NUM
aiua-13955	77	3	)	)	PUNCT
aiua-13955	77	4	,	,	PUNCT
aiua-13955	77	5	which	which	PRON
aiua-13955	77	6	demonstrated	demonstrate	VERB
aiua-13955	77	7	a	a	DET
aiua-13955	77	8	strong	strong	ADJ
aiua-13955	77	9	correlation	correlation	NOUN
aiua-13955	77	10	between	between	ADP
aiua-13955	77	11	high	high	ADJ
aiua-13955	77	12	il-6	il-6	NOUN
aiua-13955	77	13	levels	level	NOUN
aiua-13955	77	14	and	and	CCONJ
aiua-13955	77	15	worse	bad	ADJ
aiua-13955	77	16	overall	overall	ADJ
aiua-13955	77	17	os	os	NOUN
aiua-13955	77	18	,	,	PUNCT
aiua-13955	77	19	reporting	report	VERB
aiua-13955	77	20	an	an	DET
aiua-13955	77	21	hr	hr	NOUN
aiua-13955	77	22	of	of	ADP
aiua-13955	77	23	3.03	3.03	NUM
aiua-13955	77	24	(	(	PUNCT
aiua-13955	77	25	95	95	NUM
aiua-13955	77	26	%	%	NOUN
aiua-13955	77	27	ci	ci	NOUN
aiua-13955	77	28	:	:	PUNCT
aiua-13955	77	29	2.37	2.37	NUM
aiua-13955	77	30	-	-	SYM
aiua-13955	77	31	3.70	3.70	NUM
aiua-13955	77	32	)	)	PUNCT
aiua-13955	77	33	(	(	PUNCT
aiua-13955	77	34	16	16	NUM
aiua-13955	77	35	)	)	PUNCT
aiua-13955	77	36	.	.	PUNCT
aiua-13955	78	1	however	however	ADV
aiua-13955	78	2	,	,	PUNCT
aiua-13955	78	3	our	our	PRON
aiua-13955	78	4	study	study	NOUN
aiua-13955	78	5	extends	extend	VERB
aiua-13955	78	6	this	this	DET
aiua-13955	78	7	understanding	understanding	NOUN
aiua-13955	78	8	by	by	ADP
aiua-13955	78	9	quantifying	quantify	VERB
aiua-13955	78	10	the	the	DET
aiua-13955	78	11	prognostic	prognostic	ADJ
aiua-13955	78	12	advantage	advantage	NOUN
aiua-13955	78	13	associated	associate	VERB
aiua-13955	78	14	with	with	ADP
aiua-13955	78	15	low	low	ADJ
aiua-13955	78	16	il-6	il-6	NOUN
aiua-13955	78	17	levels	level	NOUN
aiua-13955	78	18	:	:	PUNCT
aiua-13955	78	19	a	a	DET
aiua-13955	78	20	5.36	5.36	NUM
aiua-13955	78	21	-	-	PUNCT
aiua-13955	78	22	month	month	NOUN
aiua-13955	78	23	os	os	NOUN
aiua-13955	78	24	benefit	benefit	NOUN
aiua-13955	78	25	(	(	PUNCT
aiua-13955	78	26	95	95	NUM
aiua-13955	78	27	%	%	NOUN
aiua-13955	78	28	ci	ci	NOUN
aiua-13955	78	29	:	:	PUNCT
aiua-13955	78	30	2.2	2.2	NUM
aiua-13955	78	31	-	-	SYM
aiua-13955	78	32	8.53	8.53	NUM
aiua-13955	78	33	;	;	PUNCT
aiua-13955	78	34	p	p	X
aiua-13955	78	35	<	<	X
aiua-13955	78	36	0.001	0.001	NUM
aiua-13955	78	37	)	)	PUNCT
aiua-13955	78	38	and	and	CCONJ
aiua-13955	78	39	a	a	DET
aiua-13955	78	40	6.41	6.41	NUM
aiua-13955	78	41	-	-	PUNCT
aiua-13955	78	42	month	month	NOUN
aiua-13955	78	43	improvement	improvement	NOUN
aiua-13955	78	44	in	in	ADP
aiua-13955	78	45	progression	progression	NOUN
aiua-13955	78	46	-	-	PUNCT
aiua-13955	78	47	free	free	ADJ
aiua-13955	78	48	survival	survival	NOUN
aiua-13955	78	49	(	(	PUNCT
aiua-13955	78	50	pfs	pfs	PROPN
aiua-13955	78	51	)	)	PUNCT
aiua-13955	78	52	(	(	PUNCT
aiua-13955	78	53	95	95	NUM
aiua-13955	78	54	%	%	NOUN
aiua-13955	78	55	ci	ci	NOUN
aiua-13955	78	56	:	:	PUNCT
aiua-13955	78	57	1.3	1.3	NUM
aiua-13955	78	58	-	-	SYM
aiua-13955	78	59	11.53	11.53	NUM
aiua-13955	78	60	;	;	PUNCT
aiua-13955	78	61	p	p	X
aiua-13955	78	62	=	=	NOUN
aiua-13955	78	63	0.01	0.01	NUM
aiua-13955	78	64	)	)	PUNCT
aiua-13955	78	65	.	.	PUNCT
aiua-13955	79	1	notably	notably	ADV
aiua-13955	79	2	,	,	PUNCT
aiua-13955	79	3	our	our	PRON
aiua-13955	79	4	analysis	analysis	NOUN
aiua-13955	79	5	yielded	yield	VERB
aiua-13955	79	6	a	a	DET
aiua-13955	79	7	lower	low	ADJ
aiua-13955	79	8	degree	degree	NOUN
aiua-13955	79	9	of	of	ADP
aiua-13955	79	10	heterogeneity	heterogeneity	NOUN
aiua-13955	79	11	(	(	PUNCT
aiua-13955	79	12	i²	i²	NOUN
aiua-13955	79	13	=	=	PUNCT
aiua-13955	79	14	0	0	NUM
aiua-13955	79	15	%	%	NOUN
aiua-13955	79	16	for	for	ADP
aiua-13955	79	17	os	os	NOUN
aiua-13955	79	18	)	)	PUNCT
aiua-13955	79	19	compared	compare	VERB
aiua-13955	79	20	to	to	ADP
aiua-13955	79	21	that	that	PRON
aiua-13955	79	22	of	of	ADP
aiua-13955	79	23	wang	wang	PROPN
aiua-13955	79	24	et	et	PROPN
aiua-13955	79	25	al	al	PROPN
aiua-13955	79	26	.	.	PROPN
aiua-13955	79	27	,	,	PUNCT
aiua-13955	79	28	which	which	PRON
aiua-13955	79	29	reported	report	VERB
aiua-13955	79	30	a	a	DET
aiua-13955	79	31	markedly	markedly	ADV
aiua-13955	79	32	high	high	ADJ
aiua-13955	79	33	heterogeneity	heterogeneity	NOUN
aiua-13955	79	34	(	(	PUNCT
aiua-13955	79	35	i²	i²	NOUN
aiua-13955	79	36	=	=	PUNCT
aiua-13955	79	37	98	98	NUM
aiua-13955	79	38	%	%	NOUN
aiua-13955	79	39	)	)	PUNCT
aiua-13955	79	40	.	.	PUNCT
aiua-13955	80	1	this	this	DET
aiua-13955	80	2	consistency	consistency	NOUN
aiua-13955	80	3	across	across	ADP
aiua-13955	80	4	diverse	diverse	ADJ
aiua-13955	80	5	methodologies	methodology	NOUN
aiua-13955	80	6	and	and	CCONJ
aiua-13955	80	7	patient	patient	ADJ
aiua-13955	80	8	populations	population	NOUN
aiua-13955	80	9	underscores	underscore	VERB
aiua-13955	80	10	il-6	il-6	PRON
aiua-13955	80	11	’s	’s	PART
aiua-13955	80	12	biological	biological	ADJ
aiua-13955	80	13	role	role	NOUN
aiua-13955	80	14	as	as	ADP
aiua-13955	80	15	a	a	DET
aiua-13955	80	16	key	key	ADJ
aiua-13955	80	17	driver	driver	NOUN
aiua-13955	80	18	of	of	ADP
aiua-13955	80	19	rcc	rcc	PROPN
aiua-13955	80	20	progression	progression	NOUN
aiua-13955	80	21	,	,	PUNCT
aiua-13955	80	22	plausibly	plausibly	ADV
aiua-13955	80	23	through	through	ADP
aiua-13955	80	24	mechanisms	mechanism	NOUN
aiua-13955	80	25	of	of	ADP
aiua-13955	80	26	angiogenesis	angiogenesis	NOUN
aiua-13955	80	27	,	,	PUNCT
aiua-13955	80	28	immune	immune	ADJ
aiua-13955	80	29	evasion	evasion	NOUN
aiua-13955	80	30	,	,	PUNCT
aiua-13955	80	31	and	and	CCONJ
aiua-13955	80	32	resistance	resistance	NOUN
aiua-13955	80	33	to	to	ADP
aiua-13955	80	34	therapy	therapy	NOUN
aiua-13955	80	35	,	,	PUNCT
aiua-13955	80	36	as	as	SCONJ
aiua-13955	80	37	previously	previously	ADV
aiua-13955	80	38	postulated	postulate	VERB
aiua-13955	80	39	(	(	PUNCT
aiua-13955	80	40	17	17	NUM
aiua-13955	80	41	-	-	SYM
aiua-13955	80	42	19	19	NUM
aiua-13955	80	43	)	)	PUNCT
aiua-13955	80	44	.	.	PUNCT
aiua-13955	81	1	from	from	ADP
aiua-13955	81	2	a	a	DET
aiua-13955	81	3	biological	biological	ADJ
aiua-13955	81	4	and	and	CCONJ
aiua-13955	81	5	clinical	clinical	ADJ
aiua-13955	81	6	standpoint	standpoint	NOUN
aiua-13955	81	7	,	,	PUNCT
aiua-13955	81	8	the	the	DET
aiua-13955	81	9	prognostic	prognostic	ADJ
aiua-13955	81	10	relevance	relevance	NOUN
aiua-13955	81	11	of	of	ADP
aiua-13955	81	12	il-6	il-6	NOUN
aiua-13955	81	13	is	be	AUX
aiua-13955	81	14	mechanistically	mechanistically	ADV
aiua-13955	81	15	plausible	plausible	ADJ
aiua-13955	81	16	.	.	PUNCT
aiua-13955	82	1	preclinical	preclinical	ADJ
aiua-13955	82	2	data	datum	NOUN
aiua-13955	82	3	have	have	AUX
aiua-13955	82	4	demonstrated	demonstrate	VERB
aiua-13955	82	5	that	that	SCONJ
aiua-13955	82	6	il-6	il-6	NOUN
aiua-13955	82	7	activates	activate	VERB
aiua-13955	82	8	the	the	DET
aiua-13955	82	9	jak	jak	PROPN
aiua-13955	82	10	/	/	SYM
aiua-13955	82	11	stat3	stat3	NOUN
aiua-13955	82	12	pathway	pathway	NOUN
aiua-13955	82	13	,	,	PUNCT
aiua-13955	82	14	which	which	PRON
aiua-13955	82	15	fosters	foster	VERB
aiua-13955	82	16	tumor	tumor	NOUN
aiua-13955	82	17	proliferation	proliferation	NOUN
aiua-13955	82	18	while	while	SCONJ
aiua-13955	82	19	concurrently	concurrently	ADV
aiua-13955	82	20	impairing	impair	VERB
aiua-13955	82	21	anti	anti	ADJ
aiua-13955	82	22	-	-	ADJ
aiua-13955	82	23	tumor	tumor	ADJ
aiua-13955	82	24	immunity	immunity	NOUN
aiua-13955	82	25	(	(	PUNCT
aiua-13955	82	26	6	6	NUM
aiua-13955	82	27	)	)	PUNCT
aiua-13955	82	28	.	.	PUNCT
aiua-13955	83	1	our	our	PRON
aiua-13955	83	2	pooled	pooled	ADJ
aiua-13955	83	3	hr	hr	NOUN
aiua-13955	83	4	of	of	ADP
aiua-13955	83	5	2.06	2.06	NUM
aiua-13955	83	6	(	(	PUNCT
aiua-13955	83	7	95	95	NUM
aiua-13955	83	8	%	%	NOUN
aiua-13955	83	9	ci	ci	NOUN
aiua-13955	83	10	:	:	PUNCT
aiua-13955	83	11	-0.23	-0.23	PROPN
aiua-13955	83	12	to	to	ADP
aiua-13955	83	13	4.36	4.36	NUM
aiua-13955	83	14	)	)	PUNCT
aiua-13955	83	15	,	,	PUNCT
aiua-13955	83	16	while	while	SCONJ
aiua-13955	83	17	not	not	PART
aiua-13955	83	18	statistically	statistically	ADV
aiua-13955	83	19	significant	significant	ADJ
aiua-13955	83	20	(	(	PUNCT
aiua-13955	83	21	p	p	X
aiua-13955	83	22	=	=	NOUN
aiua-13955	83	23	0.08	0.08	NUM
aiua-13955	83	24	)	)	PUNCT
aiua-13955	83	25	,	,	PUNCT
aiua-13955	83	26	is	be	AUX
aiua-13955	83	27	consistent	consistent	ADJ
aiua-13955	83	28	with	with	ADP
aiua-13955	83	29	the	the	DET
aiua-13955	83	30	trends	trend	NOUN
aiua-13955	83	31	previously	previously	ADV
aiua-13955	83	32	reported	report	VERB
aiua-13955	83	33	(	(	PUNCT
aiua-13955	83	34	9	9	NUM
aiua-13955	83	35	)	)	PUNCT
aiua-13955	83	36	,	,	PUNCT
aiua-13955	83	37	who	who	PRON
aiua-13955	83	38	observed	observe	VERB
aiua-13955	83	39	that	that	SCONJ
aiua-13955	83	40	elevated	elevated	ADJ
aiua-13955	83	41	serum	serum	NOUN
aiua-13955	83	42	il-6	il-6	NOUN
aiua-13955	83	43	levels	level	NOUN
aiua-13955	83	44	were	be	AUX
aiua-13955	83	45	associated	associate	VERB
aiua-13955	83	46	with	with	ADP
aiua-13955	83	47	diminished	diminish	VERB
aiua-13955	83	48	os	os	NOUN
aiua-13955	83	49	in	in	ADP
aiua-13955	83	50	metastatic	metastatic	ADJ
aiua-13955	83	51	rcc	rcc	NOUN
aiua-13955	83	52	.	.	PUNCT
aiua-13955	84	1	furthermore	furthermore	ADV
aiua-13955	84	2	,	,	PUNCT
aiua-13955	84	3	the	the	DET
aiua-13955	84	4	well	well	ADV
aiua-13955	84	5	-	-	PUNCT
aiua-13955	84	6	documented	document	VERB
aiua-13955	84	7	correlation	correlation	NOUN
aiua-13955	84	8	between	between	ADP
aiua-13955	84	9	il-6	il-6	NOUN
aiua-13955	84	10	and	and	CCONJ
aiua-13955	84	11	c	c	NOUN
aiua-13955	84	12	-	-	PUNCT
aiua-13955	84	13	reactive	reactive	ADJ
aiua-13955	84	14	protein	protein	NOUN
aiua-13955	84	15	(	(	PUNCT
aiua-13955	84	16	crp	crp	NOUN
aiua-13955	84	17	)	)	PUNCT
aiua-13955	84	18	suggests	suggest	VERB
aiua-13955	84	19	crp	crp	NOUN
aiua-13955	84	20	may	may	AUX
aiua-13955	84	21	function	function	VERB
aiua-13955	84	22	as	as	ADP
aiua-13955	84	23	a	a	DET
aiua-13955	84	24	surrogate	surrogate	ADJ
aiua-13955	84	25	biomarker	biomarker	NOUN
aiua-13955	84	26	(	(	PUNCT
aiua-13955	84	27	16	16	NUM
aiua-13955	84	28	)	)	PUNCT
aiua-13955	84	29	.	.	PUNCT
aiua-13955	85	1	however	however	ADV
aiua-13955	85	2	,	,	PUNCT
aiua-13955	85	3	our	our	PRON
aiua-13955	85	4	findings	finding	NOUN
aiua-13955	85	5	support	support	VERB
aiua-13955	85	6	the	the	DET
aiua-13955	85	7	notion	notion	NOUN
aiua-13955	85	8	that	that	SCONJ
aiua-13955	85	9	il-6	il-6	PRON
aiua-13955	85	10	itself	itself	PRON
aiua-13955	85	11	plays	play	VERB
aiua-13955	85	12	a	a	DET
aiua-13955	85	13	more	more	ADV
aiua-13955	85	14	direct	direct	ADJ
aiua-13955	85	15	and	and	CCONJ
aiua-13955	85	16	pivotal	pivotal	ADJ
aiua-13955	85	17	role	role	NOUN
aiua-13955	85	18	in	in	ADP
aiua-13955	85	19	rcc	rcc	PROPN
aiua-13955	85	20	biology	biology	NOUN
aiua-13955	85	21	.	.	PUNCT
aiua-13955	86	1	importantly	importantly	ADV
aiua-13955	86	2	,	,	PUNCT
aiua-13955	86	3	the	the	DET
aiua-13955	86	4	consistent	consistent	ADJ
aiua-13955	86	5	association	association	NOUN
aiua-13955	86	6	between	between	ADP
aiua-13955	86	7	elevated	elevated	ADJ
aiua-13955	86	8	il-6	il-6	NOUN
aiua-13955	86	9	levels	level	NOUN
aiua-13955	86	10	and	and	CCONJ
aiua-13955	86	11	advanced	advanced	ADJ
aiua-13955	86	12	tumor	tumor	NOUN
aiua-13955	86	13	stage	stage	NOUN
aiua-13955	86	14	(	(	PUNCT
aiua-13955	86	15	which	which	PRON
aiua-13955	86	16	documented	document	VERB
aiua-13955	86	17	in	in	ADP
aiua-13955	86	18	seven	seven	NUM
aiua-13955	86	19	of	of	ADP
aiua-13955	86	20	nine	nine	NUM
aiua-13955	86	21	included	include	VERB
aiua-13955	86	22	studies	study	NOUN
aiua-13955	86	23	)	)	PUNCT
aiua-13955	86	24	reinforces	reinforce	VERB
aiua-13955	86	25	its	its	PRON
aiua-13955	86	26	potential	potential	ADJ
aiua-13955	86	27	utility	utility	NOUN
aiua-13955	86	28	as	as	ADP
aiua-13955	86	29	a	a	DET
aiua-13955	86	30	biomarker	biomarker	NOUN
aiua-13955	86	31	for	for	ADP
aiua-13955	86	32	prognostication	prognostication	NOUN
aiua-13955	86	33	and	and	CCONJ
aiua-13955	86	34	risk	risk	NOUN
aiua-13955	86	35	stratification	stratification	NOUN
aiua-13955	86	36	.	.	PUNCT
aiua-13955	87	1	this	this	PRON
aiua-13955	87	2	is	be	AUX
aiua-13955	87	3	particularly	particularly	ADV
aiua-13955	87	4	relevant	relevant	ADJ
aiua-13955	87	5	in	in	ADP
aiua-13955	87	6	the	the	DET
aiua-13955	87	7	context	context	NOUN
aiua-13955	87	8	of	of	ADP
aiua-13955	87	9	il-6	il-6	NOUN
aiua-13955	87	10	-	-	PUNCT
aiua-13955	87	11	targeting	target	VERB
aiua-13955	87	12	therapeutic	therapeutic	ADJ
aiua-13955	87	13	agents	agent	NOUN
aiua-13955	87	14	such	such	ADJ
aiua-13955	87	15	as	as	ADP
aiua-13955	87	16	siltuximab	siltuximab	NOUN
aiua-13955	87	17	and	and	CCONJ
aiua-13955	87	18	tocilizumab	tocilizumab	NOUN
aiua-13955	87	19	(	(	PUNCT
aiua-13955	87	20	20	20	NUM
aiua-13955	87	21	)	)	PUNCT
aiua-13955	87	22	.	.	PUNCT
aiua-13955	88	1	one	one	NUM
aiua-13955	88	2	notable	notable	ADJ
aiua-13955	88	3	strength	strength	NOUN
aiua-13955	88	4	of	of	ADP
aiua-13955	88	5	our	our	PRON
aiua-13955	88	6	meta	meta	ADJ
aiua-13955	88	7	-	-	PUNCT
aiua-13955	88	8	analysis	analysis	NOUN
aiua-13955	88	9	lies	lie	VERB
aiua-13955	88	10	in	in	ADP
aiua-13955	88	11	its	its	PRON
aiua-13955	88	12	refined	refined	ADJ
aiua-13955	88	13	precision	precision	NOUN
aiua-13955	88	14	.	.	PUNCT
aiua-13955	89	1	by	by	ADP
aiua-13955	89	2	focusing	focus	VERB
aiua-13955	89	3	exclusively	exclusively	ADV
aiua-13955	89	4	on	on	ADP
aiua-13955	89	5	pre	pre	ADJ
aiua-13955	89	6	-	-	ADJ
aiua-13955	89	7	treatment	treatment	ADJ
aiua-13955	89	8	il-6	il-6	NOUN
aiua-13955	89	9	measurements	measurement	NOUN
aiua-13955	89	10	,	,	PUNCT
aiua-13955	89	11	we	we	PRON
aiua-13955	89	12	reduced	reduce	VERB
aiua-13955	89	13	the	the	DET
aiua-13955	89	14	confounding	confound	VERB
aiua-13955	89	15	figure	figure	NOUN
aiua-13955	89	16	3	3	NUM
aiua-13955	89	17	.	.	PUNCT
aiua-13955	89	18	progression	progression	NOUN
aiua-13955	89	19	free	free	ADJ
aiua-13955	89	20	survival	survival	NOUN
aiua-13955	89	21	difference	difference	NOUN
aiua-13955	89	22	low	low	ADV
aiua-13955	89	23	vs	vs	ADP
aiua-13955	89	24	high	high	ADJ
aiua-13955	89	25	il-6	il-6	NOUN
aiua-13955	89	26	.	.	PUNCT
aiua-13955	90	1	figure	figure	NOUN
aiua-13955	90	2	4	4	NUM
aiua-13955	90	3	.	.	PUNCT
aiua-13955	90	4	hazard	hazard	NOUN
aiua-13955	90	5	ratio	ratio	NOUN
aiua-13955	90	6	for	for	ADP
aiua-13955	90	7	poor	poor	ADJ
aiua-13955	90	8	survival	survival	NOUN
aiua-13955	90	9	.	.	PUNCT
aiua-13955	91	1	archivio	archivio	NOUN
aiua-13955	91	2	italiano	italiano	PROPN
aiua-13955	91	3	di	di	PROPN
aiua-13955	91	4	urologia	urologia	PROPN
aiua-13955	91	5	e	e	PROPN
aiua-13955	91	6	andrologia	andrologia	NOUN
aiua-13955	91	7	2025	2025	NUM
aiua-13955	91	8	;	;	PUNCT
aiua-13955	91	9	97(3):13955	97(3):13955	NUM
aiua-13955	91	10	5	5	NUM
aiua-13955	91	11	circulating	circulate	VERB
aiua-13955	91	12	il-6	il-6	NOUN
aiua-13955	91	13	and	and	CCONJ
aiua-13955	91	14	survival	survival	NOUN
aiua-13955	91	15	outcomes	outcome	NOUN
aiua-13955	91	16	in	in	ADP
aiua-13955	91	17	renal	renal	ADJ
aiua-13955	91	18	cell	cell	NOUN
aiua-13955	91	19	carcinoma	carcinoma	NOUN
aiua-13955	91	20	:	:	PUNCT
aiua-13955	91	21	a	a	DET
aiua-13955	91	22	systematic	systematic	ADJ
aiua-13955	91	23	review	review	NOUN
aiua-13955	91	24	and	and	CCONJ
aiua-13955	91	25	meta	meta	ADJ
aiua-13955	91	26	-	-	PUNCT
aiua-13955	91	27	analysis	analysis	NOUN
aiua-13955	91	28	influence	influence	NOUN
aiua-13955	91	29	of	of	ADP
aiua-13955	91	30	systemic	systemic	ADJ
aiua-13955	91	31	therapies	therapy	NOUN
aiua-13955	91	32	,	,	PUNCT
aiua-13955	91	33	particularly	particularly	ADV
aiua-13955	91	34	immunotherapy	immunotherapy	NOUN
aiua-13955	91	35	,	,	PUNCT
aiua-13955	91	36	which	which	PRON
aiua-13955	91	37	affected	affect	VERB
aiua-13955	91	38	a	a	DET
aiua-13955	91	39	substantial	substantial	ADJ
aiua-13955	91	40	proportion	proportion	NOUN
aiua-13955	91	41	(	(	PUNCT
aiua-13955	91	42	60	60	NUM
aiua-13955	91	43	%	%	NOUN
aiua-13955	91	44	)	)	PUNCT
aiua-13955	91	45	of	of	ADP
aiua-13955	91	46	patients	patient	NOUN
aiua-13955	91	47	in	in	ADP
aiua-13955	91	48	wang	wang	PROPN
aiua-13955	91	49	et	et	PROPN
aiua-13955	91	50	al	al	PROPN
aiua-13955	91	51	.	.	PROPN
aiua-13955	91	52	’s	’s	PART
aiua-13955	91	53	cohort	cohort	NOUN
aiua-13955	91	54	(	(	PUNCT
aiua-13955	91	55	16	16	NUM
aiua-13955	91	56	)	)	PUNCT
aiua-13955	91	57	.	.	PUNCT
aiua-13955	92	1	in	in	ADP
aiua-13955	92	2	terms	term	NOUN
aiua-13955	92	3	of	of	ADP
aiua-13955	92	4	methodological	methodological	ADJ
aiua-13955	92	5	rigor	rigor	NOUN
aiua-13955	92	6	,	,	PUNCT
aiua-13955	92	7	our	our	PRON
aiua-13955	92	8	use	use	NOUN
aiua-13955	92	9	of	of	ADP
aiua-13955	92	10	a	a	DET
aiua-13955	92	11	random	random	ADJ
aiua-13955	92	12	-	-	PUNCT
aiua-13955	92	13	effects	effect	NOUN
aiua-13955	92	14	model	model	NOUN
aiua-13955	92	15	appropriately	appropriately	ADV
aiua-13955	92	16	accounted	account	VERB
aiua-13955	92	17	for	for	ADP
aiua-13955	92	18	heterogeneity	heterogeneity	NOUN
aiua-13955	92	19	in	in	ADP
aiua-13955	92	20	il-6	il-6	NOUN
aiua-13955	92	21	cutoffs	cutoff	NOUN
aiua-13955	92	22	(	(	PUNCT
aiua-13955	92	23	ranging	range	VERB
aiua-13955	92	24	from	from	ADP
aiua-13955	92	25	>	>	X
aiua-13955	92	26	5	5	NUM
aiua-13955	92	27	pg	pg	NOUN
aiua-13955	92	28	/	/	SYM
aiua-13955	92	29	ml	ml	X
aiua-13955	92	30	to	to	PART
aiua-13955	92	31	≥	≥	NOUN
aiua-13955	92	32	35	35	NUM
aiua-13955	92	33	pg	pg	NOUN
aiua-13955	92	34	/	/	SYM
aiua-13955	92	35	ml	ml	NOUN
aiua-13955	92	36	)	)	PUNCT
aiua-13955	92	37	and	and	CCONJ
aiua-13955	92	38	assay	assay	VERB
aiua-13955	92	39	techniques	technique	NOUN
aiua-13955	92	40	,	,	PUNCT
aiua-13955	92	41	yet	yet	CCONJ
aiua-13955	92	42	still	still	ADV
aiua-13955	92	43	yielded	yield	VERB
aiua-13955	92	44	consistent	consistent	ADJ
aiua-13955	92	45	os	os	NOUN
aiua-13955	92	46	and	and	CCONJ
aiua-13955	92	47	pfs	pfs	PROPN
aiua-13955	92	48	differences	difference	NOUN
aiua-13955	92	49	.	.	PUNCT
aiua-13955	93	1	the	the	DET
aiua-13955	93	2	observed	observed	ADJ
aiua-13955	93	3	6.41	6.41	NUM
aiua-13955	93	4	month	month	NOUN
aiua-13955	93	5	pfs	pfs	ADJ
aiua-13955	93	6	advantage	advantage	NOUN
aiua-13955	93	7	is	be	AUX
aiua-13955	93	8	not	not	PART
aiua-13955	93	9	only	only	ADV
aiua-13955	93	10	statistically	statistically	ADV
aiua-13955	93	11	significant	significant	ADJ
aiua-13955	93	12	but	but	CCONJ
aiua-13955	93	13	also	also	ADV
aiua-13955	93	14	clinically	clinically	ADV
aiua-13955	93	15	meaningful	meaningful	ADJ
aiua-13955	93	16	,	,	PUNCT
aiua-13955	93	17	suggesting	suggest	VERB
aiua-13955	93	18	that	that	SCONJ
aiua-13955	93	19	il-6	il-6	PRON
aiua-13955	93	20	may	may	AUX
aiua-13955	93	21	serve	serve	VERB
aiua-13955	93	22	as	as	ADP
aiua-13955	93	23	a	a	DET
aiua-13955	93	24	stratifying	stratify	VERB
aiua-13955	93	25	tool	tool	NOUN
aiua-13955	93	26	in	in	ADP
aiua-13955	93	27	selecting	select	VERB
aiua-13955	93	28	patients	patient	NOUN
aiua-13955	93	29	for	for	ADP
aiua-13955	93	30	adjuvant	adjuvant	NOUN
aiua-13955	93	31	or	or	CCONJ
aiua-13955	93	32	intensified	intensify	VERB
aiua-13955	93	33	therapy	therapy	NOUN
aiua-13955	93	34	,	,	PUNCT
aiua-13955	93	35	especially	especially	ADV
aiua-13955	93	36	within	within	ADP
aiua-13955	93	37	the	the	DET
aiua-13955	93	38	metastatic	metastatic	ADJ
aiua-13955	93	39	setting	setting	NOUN
aiua-13955	93	40	.	.	PUNCT
aiua-13955	94	1	nonetheless	nonetheless	ADV
aiua-13955	94	2	,	,	PUNCT
aiua-13955	94	3	several	several	ADJ
aiua-13955	94	4	limitations	limitation	NOUN
aiua-13955	94	5	must	must	AUX
aiua-13955	94	6	be	be	AUX
aiua-13955	94	7	acknowledged	acknowledge	VERB
aiua-13955	94	8	.	.	PUNCT
aiua-13955	95	1	the	the	DET
aiua-13955	95	2	high	high	ADJ
aiua-13955	95	3	heterogeneity	heterogeneity	NOUN
aiua-13955	95	4	observed	observe	VERB
aiua-13955	95	5	in	in	ADP
aiua-13955	95	6	the	the	DET
aiua-13955	95	7	hr	hr	NOUN
aiua-13955	95	8	analysis	analysis	NOUN
aiua-13955	95	9	(	(	PUNCT
aiua-13955	95	10	i²	i²	NOUN
aiua-13955	95	11	=	=	PUNCT
aiua-13955	95	12	89.19	89.19	NUM
aiua-13955	95	13	%	%	NOUN
aiua-13955	95	14	)	)	PUNCT
aiua-13955	95	15	reflects	reflect	VERB
aiua-13955	95	16	substantial	substantial	ADJ
aiua-13955	95	17	methodological	methodological	ADJ
aiua-13955	95	18	variation	variation	NOUN
aiua-13955	95	19	among	among	ADP
aiua-13955	95	20	the	the	DET
aiua-13955	95	21	included	include	VERB
aiua-13955	95	22	studies	study	NOUN
aiua-13955	95	23	,	,	PUNCT
aiua-13955	95	24	including	include	VERB
aiua-13955	95	25	differences	difference	NOUN
aiua-13955	95	26	in	in	ADP
aiua-13955	95	27	detection	detection	NOUN
aiua-13955	95	28	platforms	platform	NOUN
aiua-13955	95	29	(	(	PUNCT
aiua-13955	95	30	elisa	elisa	X
aiua-13955	95	31	versus	versus	ADP
aiua-13955	95	32	immunohistochemistry	immunohistochemistry	NOUN
aiua-13955	95	33	)	)	PUNCT
aiua-13955	95	34	,	,	PUNCT
aiua-13955	95	35	biological	biological	ADJ
aiua-13955	95	36	samples	sample	NOUN
aiua-13955	95	37	(	(	PUNCT
aiua-13955	95	38	serum	serum	NOUN
aiua-13955	95	39	versus	versus	ADP
aiua-13955	95	40	tumor	tumor	NOUN
aiua-13955	95	41	tissue	tissue	NOUN
aiua-13955	95	42	)	)	PUNCT
aiua-13955	95	43	,	,	PUNCT
aiua-13955	95	44	and	and	CCONJ
aiua-13955	95	45	patient	patient	ADJ
aiua-13955	95	46	populations	population	NOUN
aiua-13955	95	47	(	(	PUNCT
aiua-13955	95	48	localized	localized	ADJ
aiua-13955	95	49	versus	versus	ADP
aiua-13955	95	50	metastatic	metastatic	ADJ
aiua-13955	95	51	rcc	rcc	PROPN
aiua-13955	95	52	)	)	PUNCT
aiua-13955	95	53	.	.	PUNCT
aiua-13955	96	1	additionally	additionally	ADV
aiua-13955	96	2	,	,	PUNCT
aiua-13955	96	3	the	the	DET
aiua-13955	96	4	small	small	ADJ
aiua-13955	96	5	sample	sample	NOUN
aiua-13955	96	6	sizes	size	NOUN
aiua-13955	96	7	in	in	ADP
aiua-13955	96	8	some	some	DET
aiua-13955	96	9	included	include	VERB
aiua-13955	96	10	studies	study	NOUN
aiua-13955	96	11	raise	raise	VERB
aiua-13955	96	12	concerns	concern	NOUN
aiua-13955	96	13	about	about	ADP
aiua-13955	96	14	potential	potential	ADJ
aiua-13955	96	15	effect	effect	NOUN
aiua-13955	96	16	size	size	NOUN
aiua-13955	96	17	inflation	inflation	NOUN
aiua-13955	96	18	.	.	PUNCT
aiua-13955	97	1	publication	publication	NOUN
aiua-13955	97	2	bias	bias	NOUN
aiua-13955	97	3	,	,	PUNCT
aiua-13955	97	4	although	although	SCONJ
aiua-13955	97	5	not	not	PART
aiua-13955	97	6	formally	formally	ADV
aiua-13955	97	7	detected	detect	VERB
aiua-13955	97	8	due	due	ADP
aiua-13955	97	9	to	to	ADP
aiua-13955	97	10	the	the	DET
aiua-13955	97	11	small	small	ADJ
aiua-13955	97	12	number	number	NOUN
aiua-13955	97	13	of	of	ADP
aiua-13955	97	14	included	include	VERB
aiua-13955	97	15	studies	study	NOUN
aiua-13955	97	16	(	(	PUNCT
aiua-13955	97	17	n	n	NOUN
aiua-13955	97	18	=	=	SYM
aiua-13955	97	19	9	9	NUM
aiua-13955	97	20	)	)	PUNCT
aiua-13955	97	21	,	,	PUNCT
aiua-13955	97	22	can	can	AUX
aiua-13955	97	23	not	not	PART
aiua-13955	97	24	be	be	AUX
aiua-13955	97	25	definitively	definitively	ADV
aiua-13955	97	26	ruled	rule	VERB
aiua-13955	97	27	out	out	ADP
aiua-13955	97	28	.	.	PUNCT
aiua-13955	98	1	the	the	DET
aiua-13955	98	2	clinical	clinical	ADJ
aiua-13955	98	3	implications	implication	NOUN
aiua-13955	98	4	of	of	ADP
aiua-13955	98	5	our	our	PRON
aiua-13955	98	6	findings	finding	NOUN
aiua-13955	98	7	are	be	AUX
aiua-13955	98	8	considerable	considerable	ADJ
aiua-13955	98	9	.	.	PUNCT
aiua-13955	99	1	integrating	integrate	VERB
aiua-13955	99	2	il-6	il-6	NOUN
aiua-13955	99	3	into	into	ADP
aiua-13955	99	4	existing	exist	VERB
aiua-13955	99	5	prognostic	prognostic	ADJ
aiua-13955	99	6	frameworks	framework	NOUN
aiua-13955	99	7	,	,	PUNCT
aiua-13955	99	8	such	such	ADJ
aiua-13955	99	9	as	as	ADP
aiua-13955	99	10	the	the	DET
aiua-13955	99	11	international	international	ADJ
aiua-13955	99	12	metastatic	metastatic	PROPN
aiua-13955	99	13	rcc	rcc	PROPN
aiua-13955	99	14	database	database	PROPN
aiua-13955	99	15	consortium	consortium	PROPN
aiua-13955	99	16	(	(	PUNCT
aiua-13955	99	17	imdc	imdc	PROPN
aiua-13955	99	18	)	)	PUNCT
aiua-13955	99	19	model	model	NOUN
aiua-13955	99	20	,	,	PUNCT
aiua-13955	99	21	may	may	AUX
aiua-13955	99	22	enhance	enhance	VERB
aiua-13955	99	23	risk	risk	NOUN
aiua-13955	99	24	stratification	stratification	NOUN
aiua-13955	99	25	and	and	CCONJ
aiua-13955	99	26	inform	inform	VERB
aiua-13955	99	27	therapeutic	therapeutic	ADJ
aiua-13955	99	28	decisions	decision	NOUN
aiua-13955	99	29	.	.	PUNCT
aiua-13955	100	1	patients	patient	NOUN
aiua-13955	100	2	with	with	ADP
aiua-13955	100	3	elevated	elevated	ADJ
aiua-13955	100	4	il-6	il-6	NOUN
aiua-13955	100	5	may	may	AUX
aiua-13955	100	6	benefit	benefit	VERB
aiua-13955	100	7	from	from	ADP
aiua-13955	100	8	risk	risk	NOUN
aiua-13955	100	9	-	-	PUNCT
aiua-13955	100	10	adapted	adapt	VERB
aiua-13955	100	11	surveillance	surveillance	NOUN
aiua-13955	100	12	protocols	protocol	NOUN
aiua-13955	100	13	and	and	CCONJ
aiua-13955	100	14	may	may	AUX
aiua-13955	100	15	represent	represent	VERB
aiua-13955	100	16	an	an	DET
aiua-13955	100	17	ideal	ideal	ADJ
aiua-13955	100	18	target	target	NOUN
aiua-13955	100	19	population	population	NOUN
aiua-13955	100	20	for	for	ADP
aiua-13955	100	21	clinical	clinical	ADJ
aiua-13955	100	22	trials	trial	NOUN
aiua-13955	100	23	evaluating	evaluate	VERB
aiua-13955	100	24	the	the	DET
aiua-13955	100	25	efficacy	efficacy	NOUN
aiua-13955	100	26	of	of	ADP
aiua-13955	100	27	il-6	il-6	NOUN
aiua-13955	100	28	blockade	blockade	NOUN
aiua-13955	100	29	.	.	PUNCT
aiua-13955	101	1	preclinical	preclinical	ADJ
aiua-13955	101	2	studies	study	NOUN
aiua-13955	101	3	have	have	AUX
aiua-13955	101	4	shown	show	VERB
aiua-13955	101	5	promising	promise	VERB
aiua-13955	101	6	synergy	synergy	NOUN
aiua-13955	101	7	between	between	ADP
aiua-13955	101	8	il-6	il-6	NOUN
aiua-13955	101	9	inhibition	inhibition	NOUN
aiua-13955	101	10	and	and	CCONJ
aiua-13955	101	11	vegf	vegf	PROPN
aiua-13955	101	12	-	-	PUNCT
aiua-13955	101	13	tkis	tkis	PROPN
aiua-13955	101	14	(	(	PUNCT
aiua-13955	101	15	19	19	NUM
aiua-13955	101	16	,	,	PUNCT
aiua-13955	101	17	21	21	NUM
aiua-13955	101	18	)	)	PUNCT
aiua-13955	101	19	,	,	PUNCT
aiua-13955	101	20	thus	thus	ADV
aiua-13955	101	21	warrants	warrant	VERB
aiua-13955	101	22	further	far	ADV
aiua-13955	101	23	clinical	clinical	ADJ
aiua-13955	101	24	exploration	exploration	NOUN
aiua-13955	101	25	.	.	PUNCT
aiua-13955	102	1	looking	look	VERB
aiua-13955	102	2	forward	forward	ADV
aiua-13955	102	3	,	,	PUNCT
aiua-13955	102	4	prospective	prospective	ADJ
aiua-13955	102	5	trials	trial	NOUN
aiua-13955	102	6	should	should	AUX
aiua-13955	102	7	prioritize	prioritize	VERB
aiua-13955	102	8	the	the	DET
aiua-13955	102	9	standardization	standardization	NOUN
aiua-13955	102	10	of	of	ADP
aiua-13955	102	11	il-6	il-6	NOUN
aiua-13955	102	12	assays	assay	NOUN
aiua-13955	102	13	(	(	PUNCT
aiua-13955	102	14	ideally	ideally	ADV
aiua-13955	102	15	through	through	ADP
aiua-13955	102	16	centralized	centralized	ADJ
aiua-13955	102	17	elisa	elisa	NOUN
aiua-13955	102	18	platforms	platform	NOUN
aiua-13955	102	19	)	)	PUNCT
aiua-13955	102	20	and	and	CCONJ
aiua-13955	102	21	establish	establish	VERB
aiua-13955	102	22	consensus	consensus	NOUN
aiua-13955	102	23	on	on	ADP
aiua-13955	102	24	clinically	clinically	ADV
aiua-13955	102	25	actionable	actionable	ADJ
aiua-13955	102	26	cutoffs	cutoff	NOUN
aiua-13955	102	27	.	.	PUNCT
aiua-13955	103	1	given	give	VERB
aiua-13955	103	2	the	the	DET
aiua-13955	103	3	dual	dual	ADJ
aiua-13955	103	4	biological	biological	ADJ
aiua-13955	103	5	and	and	CCONJ
aiua-13955	103	6	prognostic	prognostic	ADJ
aiua-13955	103	7	roles	role	NOUN
aiua-13955	103	8	of	of	ADP
aiua-13955	103	9	il-6	il-6	NOUN
aiua-13955	103	10	in	in	ADP
aiua-13955	103	11	rcc	rcc	PROPN
aiua-13955	103	12	,	,	PUNCT
aiua-13955	103	13	its	its	PRON
aiua-13955	103	14	integration	integration	NOUN
aiua-13955	103	15	into	into	ADP
aiua-13955	103	16	both	both	DET
aiua-13955	103	17	biomarker	biomarker	NOUN
aiua-13955	103	18	-	-	PUNCT
aiua-13955	103	19	driven	drive	VERB
aiua-13955	103	20	clinical	clinical	ADJ
aiua-13955	103	21	trials	trial	NOUN
aiua-13955	103	22	and	and	CCONJ
aiua-13955	103	23	real	real	ADJ
aiua-13955	103	24	-	-	PUNCT
aiua-13955	103	25	world	world	NOUN
aiua-13955	103	26	prognostic	prognostic	ADJ
aiua-13955	103	27	models	model	NOUN
aiua-13955	103	28	may	may	AUX
aiua-13955	103	29	represent	represent	VERB
aiua-13955	103	30	the	the	DET
aiua-13955	103	31	next	next	ADJ
aiua-13955	103	32	advance	advance	NOUN
aiua-13955	103	33	in	in	ADP
aiua-13955	103	34	personalized	personalized	ADJ
aiua-13955	103	35	therapy	therapy	NOUN
aiua-13955	103	36	for	for	ADP
aiua-13955	103	37	this	this	DET
aiua-13955	103	38	aggressive	aggressive	ADJ
aiua-13955	103	39	malignancy	malignancy	NOUN
aiua-13955	103	40	.	.	PUNCT
aiua-13955	104	1	conclusions	conclusion	NOUN
aiua-13955	104	2	elevated	elevate	VERB
aiua-13955	104	3	il-6	il-6	NOUN
aiua-13955	104	4	levels	level	NOUN
aiua-13955	104	5	are	be	AUX
aiua-13955	104	6	significantly	significantly	ADV
aiua-13955	104	7	associated	associate	VERB
aiua-13955	104	8	with	with	ADP
aiua-13955	104	9	poorer	poor	ADJ
aiua-13955	104	10	overall	overall	ADJ
aiua-13955	104	11	and	and	CCONJ
aiua-13955	104	12	progression	progression	NOUN
aiua-13955	104	13	-	-	PUNCT
aiua-13955	104	14	free	free	ADJ
aiua-13955	104	15	survival	survival	NOUN
aiua-13955	104	16	in	in	ADP
aiua-13955	104	17	patients	patient	NOUN
aiua-13955	104	18	with	with	ADP
aiua-13955	104	19	renal	renal	ADJ
aiua-13955	104	20	cell	cell	NOUN
aiua-13955	104	21	carcinoma	carcinoma	NOUN
aiua-13955	104	22	,	,	PUNCT
aiua-13955	104	23	confirming	confirm	VERB
aiua-13955	104	24	its	its	PRON
aiua-13955	104	25	role	role	NOUN
aiua-13955	104	26	as	as	ADP
aiua-13955	104	27	a	a	DET
aiua-13955	104	28	negative	negative	ADJ
aiua-13955	104	29	prognostic	prognostic	ADJ
aiua-13955	104	30	biomarker	biomarker	NOUN
aiua-13955	104	31	.	.	PUNCT
aiua-13955	105	1	these	these	DET
aiua-13955	105	2	findings	finding	NOUN
aiua-13955	105	3	support	support	VERB
aiua-13955	105	4	the	the	DET
aiua-13955	105	5	integration	integration	NOUN
aiua-13955	105	6	of	of	ADP
aiua-13955	105	7	il-6	il-6	NOUN
aiua-13955	105	8	measurement	measurement	NOUN
aiua-13955	105	9	into	into	ADP
aiua-13955	105	10	clinical	clinical	ADJ
aiua-13955	105	11	risk	risk	NOUN
aiua-13955	105	12	stratification	stratification	NOUN
aiua-13955	105	13	and	and	CCONJ
aiua-13955	105	14	therapeutic	therapeutic	ADJ
aiua-13955	105	15	decision	decision	NOUN
aiua-13955	105	16	-	-	PUNCT
aiua-13955	105	17	making	making	NOUN
aiua-13955	105	18	in	in	ADP
aiua-13955	105	19	rcc	rcc	PROPN
aiua-13955	105	20	management	management	NOUN
aiua-13955	105	21	.	.	PUNCT
aiua-13955	106	1	references	reference	NOUN
aiua-13955	106	2	1	1	NUM
aiua-13955	106	3	.	.	PUNCT
aiua-13955	107	1	hsieh	hsieh	PROPN
aiua-13955	107	2	j	j	PROPN
aiua-13955	107	3	,	,	PUNCT
aiua-13955	107	4	purdue	purdue	PROPN
aiua-13955	107	5	m	m	PROPN
aiua-13955	107	6	,	,	PUNCT
aiua-13955	107	7	signoretti	signoretti	PROPN
aiua-13955	107	8	s	s	NOUN
aiua-13955	107	9	,	,	PUNCT
aiua-13955	107	10	et	et	PROPN
aiua-13955	107	11	al	al	PROPN
aiua-13955	107	12	.	.	PUNCT
aiua-13955	108	1	renal	renal	ADJ
aiua-13955	108	2	cell	cell	NOUN
aiua-13955	108	3	carcinoma	carcinoma	NOUN
aiua-13955	108	4	.	.	PUNCT
aiua-13955	109	1	nat	nat	PROPN
aiua-13955	109	2	rev	rev	VERB
aiua-13955	109	3	dis	dis	PROPN
aiua-13955	109	4	prim	prim	PROPN
aiua-13955	109	5	2018	2018	NUM
aiua-13955	109	6	;	;	PUNCT
aiua-13955	109	7	9:1	9:1	NUM
aiua-13955	109	8	-	-	SYM
aiua-13955	109	9	42	42	NUM
aiua-13955	109	10	.	.	PUNCT
aiua-13955	110	1	2	2	NUM
aiua-13955	110	2	.	.	X
aiua-13955	111	1	petrelli	petrelli	PROPN
aiua-13955	111	2	f	f	PROPN
aiua-13955	111	3	,	,	PUNCT
aiua-13955	111	4	vavassori	vavassori	ADP
aiua-13955	111	5	i	i	PROPN
aiua-13955	111	6	,	,	PUNCT
aiua-13955	111	7	rossitto	rossitto	PROPN
aiua-13955	111	8	m	m	PROPN
aiua-13955	111	9	,	,	PUNCT
aiua-13955	111	10	dottorini	dottorini	PROPN
aiua-13955	111	11	l.	l.	PROPN
aiua-13955	111	12	management	management	PROPN
aiua-13955	111	13	of	of	ADP
aiua-13955	111	14	metastatic	metastatic	ADJ
aiua-13955	111	15	renal	renal	ADJ
aiua-13955	111	16	cell	cell	NOUN
aiua-13955	111	17	carcinoma	carcinoma	NOUN
aiua-13955	111	18	following	follow	VERB
aiua-13955	111	19	first	first	ADJ
aiua-13955	111	20	-	-	PUNCT
aiua-13955	111	21	line	line	NOUN
aiua-13955	111	22	immune	immune	ADJ
aiua-13955	111	23	checkpoint	checkpoint	NOUN
aiua-13955	111	24	therapy	therapy	NOUN
aiua-13955	111	25	failure	failure	NOUN
aiua-13955	111	26	:	:	PUNCT
aiua-13955	111	27	a	a	DET
aiua-13955	111	28	systematic	systematic	ADJ
aiua-13955	111	29	review	review	NOUN
aiua-13955	111	30	.	.	PUNCT
aiua-13955	112	1	cancers	cancer	NOUN
aiua-13955	112	2	(	(	PUNCT
aiua-13955	112	3	basel	basel	PROPN
aiua-13955	112	4	)	)	PUNCT
aiua-13955	112	5	2024	2024	NUM
aiua-13955	112	6	;	;	PUNCT
aiua-13955	112	7	16:2598	16:2598	NUM
aiua-13955	112	8	-	-	SYM
aiua-13955	112	9	610	610	NUM
aiua-13955	112	10	.	.	PUNCT
aiua-13955	113	1	3	3	X
aiua-13955	113	2	.	.	X
aiua-13955	113	3	heidegger	heidegger	PROPN
aiua-13955	113	4	i	i	PRON
aiua-13955	113	5	,	,	PUNCT
aiua-13955	113	6	pircher	pircher	PROPN
aiua-13955	113	7	a	a	PRON
aiua-13955	113	8	,	,	PUNCT
aiua-13955	113	9	pichler	pichler	PROPN
aiua-13955	113	10	r.	r.	PROPN
aiua-13955	113	11	targeting	target	VERB
aiua-13955	113	12	the	the	DET
aiua-13955	113	13	tumor	tumor	NOUN
aiua-13955	113	14	microenvironment	microenvironment	NOUN
aiua-13955	113	15	in	in	ADP
aiua-13955	113	16	renal	renal	ADJ
aiua-13955	113	17	cell	cell	NOUN
aiua-13955	113	18	cancer	cancer	NOUN
aiua-13955	113	19	biology	biology	NOUN
aiua-13955	113	20	and	and	CCONJ
aiua-13955	113	21	therapy	therapy	NOUN
aiua-13955	113	22	.	.	PUNCT
aiua-13955	114	1	front	front	ADJ
aiua-13955	114	2	oncol	oncol	ADJ
aiua-13955	114	3	2019	2019	NUM
aiua-13955	114	4	;	;	PUNCT
aiua-13955	114	5	9:1	9:1	NUM
aiua-13955	114	6	-	-	SYM
aiua-13955	114	7	11	11	NUM
aiua-13955	114	8	.	.	PUNCT
aiua-13955	115	1	4	4	NUM
aiua-13955	115	2	.	.	X
aiua-13955	115	3	zhao	zhao	PROPN
aiua-13955	115	4	h	h	PROPN
aiua-13955	115	5	,	,	PUNCT
aiua-13955	115	6	wu	wu	PROPN
aiua-13955	115	7	l	l	PROPN
aiua-13955	115	8	,	,	PUNCT
aiua-13955	115	9	yan	yan	PROPN
aiua-13955	115	10	g	g	PROPN
aiua-13955	115	11	,	,	PUNCT
aiua-13955	115	12	et	et	PROPN
aiua-13955	115	13	al	al	PROPN
aiua-13955	115	14	.	.	PROPN
aiua-13955	116	1	inflammation	inflammation	NOUN
aiua-13955	116	2	and	and	CCONJ
aiua-13955	116	3	tumor	tumor	NOUN
aiua-13955	116	4	progression	progression	NOUN
aiua-13955	116	5	:	:	PUNCT
aiua-13955	116	6	signaling	signal	VERB
aiua-13955	116	7	pathways	pathway	NOUN
aiua-13955	116	8	and	and	CCONJ
aiua-13955	116	9	targeted	target	VERB
aiua-13955	116	10	intervention	intervention	NOUN
aiua-13955	116	11	.	.	PUNCT
aiua-13955	117	1	signal	signal	PROPN
aiua-13955	117	2	transduct	transduct	NOUN
aiua-13955	117	3	.	.	PUNCT
aiua-13955	118	1	target	target	NOUN
aiua-13955	118	2	.	.	PUNCT
aiua-13955	119	1	ther.2021	ther.2021	PRON
aiua-13955	119	2	;	;	PUNCT
aiua-13955	119	3	6:263	6:263	PROPN
aiua-13955	119	4	-	-	PUNCT
aiua-13955	119	5	308	308	NUM
aiua-13955	119	6	.	.	PUNCT
aiua-13955	120	1	5	5	NUM
aiua-13955	120	2	.	.	X
aiua-13955	120	3	pilskog	pilskog	PROPN
aiua-13955	120	4	m	m	PROPN
aiua-13955	120	5	,	,	PUNCT
aiua-13955	120	6	bostad	bostad	PROPN
aiua-13955	120	7	l	l	PROPN
aiua-13955	120	8	,	,	PUNCT
aiua-13955	120	9	edelmann	edelmann	PROPN
aiua-13955	120	10	rj	rj	PROPN
aiua-13955	120	11	,	,	PUNCT
aiua-13955	120	12	et	et	PROPN
aiua-13955	120	13	al	al	PROPN
aiua-13955	120	14	.	.	PUNCT
aiua-13955	121	1	tumour	tumour	NOUN
aiua-13955	121	2	cell	cell	NOUN
aiua-13955	121	3	expression	expression	NOUN
aiua-13955	121	4	of	of	ADP
aiua-13955	121	5	interleukin	interleukin	NOUN
aiua-13955	121	6	6	6	NUM
aiua-13955	121	7	receptor	receptor	NOUN
aiua-13955	121	8	α	α	NOUN
aiua-13955	121	9	is	be	AUX
aiua-13955	121	10	associated	associate	VERB
aiua-13955	121	11	with	with	ADP
aiua-13955	121	12	response	response	NOUN
aiua-13955	121	13	rates	rate	NOUN
aiua-13955	121	14	in	in	ADP
aiua-13955	121	15	patients	patient	NOUN
aiua-13955	121	16	treated	treat	VERB
aiua-13955	121	17	with	with	ADP
aiua-13955	121	18	sunitinib	sunitinib	NOUN
aiua-13955	121	19	for	for	ADP
aiua-13955	121	20	metastatic	metastatic	ADJ
aiua-13955	121	21	clear	clear	ADJ
aiua-13955	121	22	cell	cell	NOUN
aiua-13955	121	23	renal	renal	ADJ
aiua-13955	121	24	cell	cell	NOUN
aiua-13955	121	25	carcinoma	carcinoma	NOUN
aiua-13955	121	26	.	.	PUNCT
aiua-13955	122	1	j	j	PROPN
aiua-13955	122	2	pathol	pathol	VERB
aiua-13955	122	3	clin	clin	PROPN
aiua-13955	122	4	res	re	NOUN
aiua-13955	122	5	2018	2018	NUM
aiua-13955	122	6	;	;	PUNCT
aiua-13955	122	7	4:114	4:114	NUM
aiua-13955	122	8	-	-	SYM
aiua-13955	122	9	23	23	NUM
aiua-13955	122	10	.	.	PUNCT
aiua-13955	123	1	6	6	NUM
aiua-13955	123	2	.	.	X
aiua-13955	123	3	jian	jian	PROPN
aiua-13955	123	4	shi	shi	PROPN
aiua-13955	123	5	,	,	PUNCT
aiua-13955	123	6	wang	wang	PROPN
aiua-13955	123	7	k	k	PROPN
aiua-13955	123	8	,	,	PUNCT
aiua-13955	123	9	xiong	xiong	PROPN
aiua-13955	123	10	z	z	PROPN
aiua-13955	123	11	,	,	PUNCT
aiua-13955	123	12	et	et	PROPN
aiua-13955	123	13	al	al	PROPN
aiua-13955	123	14	.	.	PROPN
aiua-13955	123	15	impact	impact	NOUN
aiua-13955	123	16	of	of	ADP
aiua-13955	123	17	inflammation	inflammation	NOUN
aiua-13955	123	18	and	and	CCONJ
aiua-13955	123	19	immunotherapy	immunotherapy	NOUN
aiua-13955	123	20	in	in	ADP
aiua-13955	123	21	renal	renal	ADJ
aiua-13955	123	22	cell	cell	NOUN
aiua-13955	123	23	carcinoma	carcinoma	NOUN
aiua-13955	123	24	(	(	PUNCT
aiua-13955	123	25	review	review	NOUN
aiua-13955	123	26	)	)	PUNCT
aiua-13955	123	27	.	.	PUNCT
aiua-13955	124	1	oncol	oncol	ADJ
aiua-13955	124	2	.	.	PUNCT
aiua-13955	125	1	lett.2020	lett.2020	NOUN
aiua-13955	125	2	;	;	PUNCT
aiua-13955	125	3	20:272	20:272	NUM
aiua-13955	125	4	-	-	SYM
aiua-13955	125	5	84	84	NUM
aiua-13955	125	6	.	.	PUNCT
aiua-13955	126	1	7	7	X
aiua-13955	126	2	.	.	X
aiua-13955	126	3	gudbrandsdottir	gudbrandsdottir	PROPN
aiua-13955	126	4	g	g	PROPN
aiua-13955	126	5	,	,	PUNCT
aiua-13955	126	6	aarstad	aarstad	ADV
aiua-13955	126	7	hh	hh	PROPN
aiua-13955	126	8	,	,	PUNCT
aiua-13955	126	9	bostad	bostad	PROPN
aiua-13955	126	10	l	l	PROPN
aiua-13955	126	11	,	,	PUNCT
aiua-13955	126	12	et	et	PROPN
aiua-13955	126	13	al	al	PROPN
aiua-13955	126	14	.	.	PROPN
aiua-13955	126	15	serum	serum	PROPN
aiua-13955	126	16	levels	level	NOUN
aiua-13955	126	17	of	of	ADP
aiua-13955	126	18	the	the	DET
aiua-13955	126	19	il-6	il-6	NOUN
aiua-13955	126	20	family	family	NOUN
aiua-13955	126	21	of	of	ADP
aiua-13955	126	22	cytokines	cytokine	NOUN
aiua-13955	126	23	predict	predict	VERB
aiua-13955	126	24	prognosis	prognosis	NOUN
aiua-13955	126	25	in	in	ADP
aiua-13955	126	26	renal	renal	ADJ
aiua-13955	126	27	cell	cell	NOUN
aiua-13955	126	28	carcinoma	carcinoma	NOUN
aiua-13955	126	29	(	(	PUNCT
aiua-13955	126	30	rcc	rcc	PROPN
aiua-13955	126	31	)	)	PUNCT
aiua-13955	126	32	.	.	PUNCT
aiua-13955	127	1	cancer	cancer	NOUN
aiua-13955	127	2	immunol	immunol	PROPN
aiua-13955	127	3	immunother	immunother	PROPN
aiua-13955	127	4	2021	2021	NUM
aiua-13955	127	5	;	;	PUNCT
aiua-13955	127	6	70:19	70:19	NUM
aiua-13955	127	7	-	-	SYM
aiua-13955	127	8	30	30	NUM
aiua-13955	127	9	.	.	NOUN
aiua-13955	127	10	8	8	NUM
aiua-13955	127	11	.	.	X
aiua-13955	128	1	pilskog	pilskog	PROPN
aiua-13955	128	2	m	m	PROPN
aiua-13955	128	3	,	,	PUNCT
aiua-13955	128	4	nilsen	nilsen	PROPN
aiua-13955	128	5	gh	gh	PROPN
aiua-13955	128	6	,	,	PUNCT
aiua-13955	128	7	beisland	beisland	PROPN
aiua-13955	128	8	c	c	X
aiua-13955	128	9	,	,	PUNCT
aiua-13955	128	10	straume	straume	PROPN
aiua-13955	128	11	o.	o.	PROPN
aiua-13955	128	12	elevated	elevate	VERB
aiua-13955	128	13	plasma	plasma	NOUN
aiua-13955	128	14	interleukin	interleukin	NOUN
aiua-13955	128	15	6	6	NUM
aiua-13955	128	16	predicts	predict	VERB
aiua-13955	128	17	poor	poor	ADJ
aiua-13955	128	18	response	response	NOUN
aiua-13955	128	19	in	in	ADP
aiua-13955	128	20	patients	patient	NOUN
aiua-13955	128	21	treated	treat	VERB
aiua-13955	128	22	with	with	ADP
aiua-13955	128	23	sunitinib	sunitinib	NOUN
aiua-13955	128	24	for	for	ADP
aiua-13955	128	25	metastatic	metastatic	ADJ
aiua-13955	128	26	clear	clear	ADJ
aiua-13955	128	27	cell	cell	NOUN
aiua-13955	128	28	renal	renal	ADJ
aiua-13955	128	29	cell	cell	NOUN
aiua-13955	128	30	carcinoma	carcinoma	NOUN
aiua-13955	128	31	.	.	PUNCT
aiua-13955	129	1	cancer	cancer	NOUN
aiua-13955	129	2	treat	treat	VERB
aiua-13955	129	3	res	re	NOUN
aiua-13955	129	4	commun	commun	PROPN
aiua-13955	129	5	2019	2019	NUM
aiua-13955	129	6	;	;	PUNCT
aiua-13955	130	1	19:1	19:1	NUM
aiua-13955	130	2	-	-	SYM
aiua-13955	130	3	5	5	NUM
aiua-13955	130	4	.	.	NOUN
aiua-13955	130	5	9	9	NUM
aiua-13955	130	6	.	.	X
aiua-13955	130	7	negrier	negrier	PROPN
aiua-13955	130	8	s	s	PROPN
aiua-13955	130	9	,	,	PUNCT
aiua-13955	130	10	perol	perol	NOUN
aiua-13955	130	11	d	d	PROPN
aiua-13955	130	12	,	,	PUNCT
aiua-13955	130	13	menetrier	menetrier	NOUN
aiua-13955	130	14	-	-	PUNCT
aiua-13955	130	15	caux	caux	NOUN
aiua-13955	130	16	c	c	NOUN
aiua-13955	130	17	,	,	PUNCT
aiua-13955	130	18	et	et	PROPN
aiua-13955	130	19	al	al	PROPN
aiua-13955	130	20	.	.	PROPN
aiua-13955	130	21	interleukin-6	interleukin-6	PROPN
aiua-13955	130	22	,	,	PUNCT
aiua-13955	130	23	interleukin-10	interleukin-10	ADJ
aiua-13955	130	24	,	,	PUNCT
aiua-13955	130	25	and	and	CCONJ
aiua-13955	130	26	vascular	vascular	ADJ
aiua-13955	130	27	endothelial	endothelial	ADJ
aiua-13955	130	28	growth	growth	NOUN
aiua-13955	130	29	factor	factor	NOUN
aiua-13955	130	30	in	in	ADP
aiua-13955	130	31	metastatic	metastatic	ADJ
aiua-13955	130	32	renal	renal	ADJ
aiua-13955	130	33	cell	cell	NOUN
aiua-13955	130	34	carcinoma	carcinoma	NOUN
aiua-13955	130	35	:	:	PUNCT
aiua-13955	130	36	prognostic	prognostic	ADJ
aiua-13955	130	37	value	value	NOUN
aiua-13955	130	38	of	of	ADP
aiua-13955	130	39	interleukin-6	interleukin-6	NUM
aiua-13955	130	40	from	from	ADP
aiua-13955	130	41	the	the	DET
aiua-13955	130	42	groupe	groupe	PROPN
aiua-13955	130	43	français	français	PROPN
aiua-13955	130	44	d’immunothérapie	d’immunothérapie	PROPN
aiua-13955	130	45	.	.	PUNCT
aiua-13955	131	1	j	j	PROPN
aiua-13955	131	2	clin	clin	PROPN
aiua-13955	131	3	oncol	oncol	PROPN
aiua-13955	131	4	2004	2004	NUM
aiua-13955	131	5	;	;	PUNCT
aiua-13955	131	6	22:2371	22:2371	NUM
aiua-13955	131	7	-	-	SYM
aiua-13955	131	8	8	8	NUM
aiua-13955	131	9	.	.	NOUN
aiua-13955	131	10	10	10	NUM
aiua-13955	131	11	.	.	PUNCT
aiua-13955	132	1	tran	tran	PROPN
aiua-13955	132	2	ht	ht	PROPN
aiua-13955	132	3	,	,	PUNCT
aiua-13955	132	4	liu	liu	PROPN
aiua-13955	132	5	y	y	PROPN
aiua-13955	132	6	,	,	PUNCT
aiua-13955	132	7	zurita	zurita	PROPN
aiua-13955	132	8	aj	aj	PROPN
aiua-13955	132	9	,	,	PUNCT
aiua-13955	132	10	et	et	PROPN
aiua-13955	132	11	al	al	PROPN
aiua-13955	132	12	.	.	PROPN
aiua-13955	133	1	prognostic	prognostic	ADJ
aiua-13955	133	2	or	or	CCONJ
aiua-13955	133	3	predictive	predictive	ADJ
aiua-13955	133	4	plasma	plasma	NOUN
aiua-13955	133	5	cytokines	cytokine	NOUN
aiua-13955	133	6	and	and	CCONJ
aiua-13955	133	7	angiogenic	angiogenic	ADJ
aiua-13955	133	8	factors	factor	NOUN
aiua-13955	133	9	for	for	ADP
aiua-13955	133	10	patients	patient	NOUN
aiua-13955	133	11	treated	treat	VERB
aiua-13955	133	12	with	with	ADP
aiua-13955	133	13	pazopanib	pazopanib	NOUN
aiua-13955	133	14	for	for	ADP
aiua-13955	133	15	metastatic	metastatic	ADJ
aiua-13955	133	16	renal	renal	ADJ
aiua-13955	133	17	-	-	PUNCT
aiua-13955	133	18	cell	cell	NOUN
aiua-13955	133	19	cancer	cancer	NOUN
aiua-13955	133	20	:	:	PUNCT
aiua-13955	133	21	a	a	DET
aiua-13955	133	22	retrospective	retrospective	ADJ
aiua-13955	133	23	analysis	analysis	NOUN
aiua-13955	133	24	of	of	ADP
aiua-13955	133	25	phase	phase	NOUN
aiua-13955	133	26	2	2	NUM
aiua-13955	133	27	and	and	CCONJ
aiua-13955	133	28	phase	phase	NOUN
aiua-13955	133	29	3	3	NUM
aiua-13955	133	30	trials	trial	NOUN
aiua-13955	133	31	.	.	PUNCT
aiua-13955	134	1	lancet	lancet	PROPN
aiua-13955	134	2	oncol	oncol	ADJ
aiua-13955	134	3	2012	2012	NUM
aiua-13955	134	4	;	;	PUNCT
aiua-13955	134	5	13:827	13:827	NUM
aiua-13955	134	6	-	-	SYM
aiua-13955	134	7	37	37	NUM
aiua-13955	134	8	.	.	PUNCT
aiua-13955	134	9	11	11	NUM
aiua-13955	134	10	.	.	PUNCT
aiua-13955	135	1	thiounn	thiounn	NOUN
aiua-13955	135	2	n	n	CCONJ
aiua-13955	135	3	,	,	PUNCT
aiua-13955	135	4	pages	page	NOUN
aiua-13955	135	5	f	f	PROPN
aiua-13955	135	6	,	,	PUNCT
aiua-13955	135	7	flam	flam	PROPN
aiua-13955	135	8	t	t	PROPN
aiua-13955	135	9	,	,	PUNCT
aiua-13955	135	10	et	et	PROPN
aiua-13955	135	11	al	al	PROPN
aiua-13955	135	12	.	.	PROPN
aiua-13955	135	13	rapid	rapid	ADJ
aiua-13955	135	14	note	note	NOUN
aiua-13955	135	15	:	:	PUNCT
aiua-13955	135	16	il-6	il-6	NUM
aiua-13955	135	17	is	be	AUX
aiua-13955	135	18	a	a	DET
aiua-13955	135	19	survival	survival	NOUN
aiua-13955	135	20	prognostic	prognostic	ADJ
aiua-13955	135	21	factor	factor	NOUN
aiua-13955	135	22	in	in	ADP
aiua-13955	135	23	renal	renal	ADJ
aiua-13955	135	24	cell	cell	NOUN
aiua-13955	135	25	carcinoma	carcinoma	NOUN
aiua-13955	135	26	.	.	PUNCT
aiua-13955	136	1	immunol	immunol	NOUN
aiua-13955	136	2	lett	lett	PROPN
aiua-13955	136	3	1997	1997	NUM
aiua-13955	136	4	;	;	PUNCT
aiua-13955	136	5	58:121	58:121	NUM
aiua-13955	136	6	-	-	SYM
aiua-13955	136	7	4	4	NUM
aiua-13955	136	8	.	.	NOUN
aiua-13955	136	9	12	12	NUM
aiua-13955	136	10	.	.	PUNCT
aiua-13955	137	1	stadler	stadler	PROPN
aiua-13955	137	2	wm	wm	PROPN
aiua-13955	137	3	,	,	PUNCT
aiua-13955	137	4	richards	richards	PROPN
aiua-13955	137	5	jm	jm	PROPN
aiua-13955	137	6	,	,	PUNCT
aiua-13955	137	7	vogelzang	vogelzang	PROPN
aiua-13955	137	8	nj	nj	PROPN
aiua-13955	137	9	.	.	PUNCT
aiua-13955	138	1	serum	serum	PROPN
aiua-13955	138	2	interleukin-6	interleukin-6	NUM
aiua-13955	138	3	levels	level	NOUN
aiua-13955	138	4	in	in	ADP
aiua-13955	138	5	metastatic	metastatic	ADJ
aiua-13955	138	6	renal	renal	ADJ
aiua-13955	138	7	cell	cell	NOUN
aiua-13955	138	8	cancer	cancer	NOUN
aiua-13955	138	9	:	:	PUNCT
aiua-13955	138	10	correlation	correlation	NOUN
aiua-13955	138	11	with	with	ADP
aiua-13955	138	12	survival	survival	NOUN
aiua-13955	138	13	but	but	CCONJ
aiua-13955	138	14	not	not	PART
aiua-13955	138	15	an	an	DET
aiua-13955	138	16	independent	independent	ADJ
aiua-13955	138	17	prognostic	prognostic	ADJ
aiua-13955	138	18	indicator	indicator	NOUN
aiua-13955	138	19	.	.	PUNCT
aiua-13955	139	1	j.	j.	PROPN
aiua-13955	139	2	natl	natl	PROPN
aiua-13955	139	3	.	.	PUNCT
aiua-13955	140	1	cancer	cancer	PROPN
aiua-13955	140	2	inst.1992	inst.1992	PROPN
aiua-13955	140	3	;	;	PUNCT
aiua-13955	140	4	84:1835	84:1835	NUM
aiua-13955	140	5	-	-	SYM
aiua-13955	140	6	6	6	NUM
aiua-13955	140	7	.	.	NOUN
aiua-13955	140	8	13	13	NUM
aiua-13955	140	9	.	.	PUNCT
aiua-13955	141	1	costes	cost	VERB
aiua-13955	141	2	v	v	NOUN
aiua-13955	141	3	,	,	PUNCT
aiua-13955	141	4	liautard	liautard	PROPN
aiua-13955	141	5	j	j	PROPN
aiua-13955	141	6	,	,	PUNCT
aiua-13955	141	7	picot	picot	PROPN
aiua-13955	141	8	mc	mc	PROPN
aiua-13955	141	9	,	,	PUNCT
aiua-13955	141	10	et	et	PROPN
aiua-13955	141	11	al	al	PROPN
aiua-13955	141	12	.	.	PUNCT
aiua-13955	141	13	expression	expression	NOUN
aiua-13955	141	14	of	of	ADP
aiua-13955	141	15	the	the	DET
aiua-13955	141	16	interleukin	interleukin	NOUN
aiua-13955	141	17	6	6	NUM
aiua-13955	141	18	receptor	receptor	NOUN
aiua-13955	141	19	in	in	ADP
aiua-13955	141	20	primary	primary	ADJ
aiua-13955	141	21	renal	renal	ADJ
aiua-13955	141	22	cell	cell	NOUN
aiua-13955	141	23	carcinoma	carcinoma	NOUN
aiua-13955	141	24	.	.	PUNCT
aiua-13955	142	1	j	j	PROPN
aiua-13955	142	2	clin	clin	PROPN
aiua-13955	142	3	pathol	pathol	NOUN
aiua-13955	142	4	1997	1997	NUM
aiua-13955	142	5	;	;	PUNCT
aiua-13955	142	6	50:835	50:835	NUM
aiua-13955	142	7	-	-	SYM
aiua-13955	142	8	40	40	NUM
aiua-13955	142	9	.	.	PUNCT
aiua-13955	143	1	14	14	NUM
aiua-13955	143	2	.	.	PUNCT
aiua-13955	144	1	akdogan	akdogan	PROPN
aiua-13955	144	2	o	o	PROPN
aiua-13955	144	3	,	,	PUNCT
aiua-13955	144	4	turkmen	turkmen	PROPN
aiua-13955	144	5	s	s	PART
aiua-13955	144	6	,	,	PUNCT
aiua-13955	144	7	uyar	uyar	NOUN
aiua-13955	144	8	g	g	NOUN
aiua-13955	144	9	,	,	PUNCT
aiua-13955	144	10	et	et	PROPN
aiua-13955	144	11	al	al	PROPN
aiua-13955	144	12	.	.	PROPN
aiua-13955	144	13	impact	impact	NOUN
aiua-13955	144	14	of	of	ADP
aiua-13955	144	15	serum	serum	NOUN
aiua-13955	144	16	gdf-15	gdf-15	NOUN
aiua-13955	144	17	and	and	CCONJ
aiua-13955	144	18	il-6	il-6	NOUN
aiua-13955	144	19	on	on	ADP
aiua-13955	144	20	immunotherapy	immunotherapy	NOUN
aiua-13955	144	21	response	response	NOUN
aiua-13955	144	22	in	in	ADP
aiua-13955	144	23	cancer	cancer	NOUN
aiua-13955	144	24	:	:	PUNCT
aiua-13955	144	25	a	a	DET
aiua-13955	144	26	prospective	prospective	ADJ
aiua-13955	144	27	study	study	NOUN
aiua-13955	144	28	.	.	PUNCT
aiua-13955	145	1	cancers	cancer	NOUN
aiua-13955	145	2	(	(	PUNCT
aiua-13955	145	3	basel	basel	PROPN
aiua-13955	145	4	)	)	PUNCT
aiua-13955	145	5	(	(	PUNCT
aiua-13955	145	6	internet	internet	NOUN
aiua-13955	145	7	)	)	PUNCT
aiua-13955	145	8	2024	2024	NUM
aiua-13955	145	9	;	;	PUNCT
aiua-13955	145	10	16:41	16:41	NUM
aiua-13955	145	11	-	-	SYM
aiua-13955	145	12	6	6	NUM
aiua-13955	145	13	.	.	NOUN
aiua-13955	145	14	15	15	NUM
aiua-13955	145	15	.	.	PUNCT
aiua-13955	146	1	kays	kay	NOUN
aiua-13955	146	2	jk	jk	PROPN
aiua-13955	146	3	,	,	PUNCT
aiua-13955	146	4	koniaris	koniaris	PROPN
aiua-13955	146	5	lg	lg	PROPN
aiua-13955	146	6	,	,	PUNCT
aiua-13955	146	7	cooper	cooper	PROPN
aiua-13955	146	8	ca	can	AUX
aiua-13955	146	9	,	,	PUNCT
aiua-13955	146	10	et	et	PROPN
aiua-13955	146	11	al	al	PROPN
aiua-13955	146	12	.	.	PUNCT
aiua-13955	147	1	the	the	DET
aiua-13955	147	2	combination	combination	NOUN
aiua-13955	147	3	of	of	ADP
aiua-13955	147	4	low	low	ADJ
aiua-13955	147	5	skeletal	skeletal	ADJ
aiua-13955	147	6	muscle	muscle	NOUN
aiua-13955	147	7	mass	mass	NOUN
aiua-13955	147	8	and	and	CCONJ
aiua-13955	147	9	high	high	ADJ
aiua-13955	147	10	tumor	tumor	NOUN
aiua-13955	147	11	interleukin-6	interleukin-6	NUM
aiua-13955	147	12	associates	associate	NOUN
aiua-13955	147	13	with	with	ADP
aiua-13955	147	14	declarations	declaration	NOUN
aiua-13955	147	15	ethical	ethical	ADJ
aiua-13955	147	16	approval	approval	NOUN
aiua-13955	147	17	and	and	CCONJ
aiua-13955	147	18	consent	consent	NOUN
aiua-13955	147	19	:	:	PUNCT
aiua-13955	147	20	not	not	PART
aiua-13955	147	21	applicable	applicable	ADJ
aiua-13955	147	22	.	.	PUNCT
aiua-13955	148	1	consent	consent	NOUN
aiua-13955	148	2	for	for	ADP
aiua-13955	148	3	publication	publication	NOUN
aiua-13955	148	4	:	:	PUNCT
aiua-13955	148	5	not	not	PART
aiua-13955	148	6	applicable	applicable	ADJ
aiua-13955	148	7	.	.	PUNCT
aiua-13955	149	1	availability	availability	NOUN
aiua-13955	149	2	of	of	ADP
aiua-13955	149	3	data	datum	NOUN
aiua-13955	149	4	and	and	CCONJ
aiua-13955	149	5	materials	material	NOUN
aiua-13955	149	6	:	:	PUNCT
aiua-13955	149	7	all	all	DET
aiua-13955	149	8	data	datum	NOUN
aiua-13955	149	9	generated	generate	VERB
aiua-13955	149	10	or	or	CCONJ
aiua-13955	149	11	analyzed	analyze	VERB
aiua-13955	149	12	during	during	ADP
aiua-13955	149	13	this	this	DET
aiua-13955	149	14	study	study	NOUN
aiua-13955	149	15	are	be	AUX
aiua-13955	149	16	included	include	VERB
aiua-13955	149	17	in	in	ADP
aiua-13955	149	18	this	this	DET
aiua-13955	149	19	published	publish	VERB
aiua-13955	149	20	article	article	NOUN
aiua-13955	149	21	.	.	PUNCT
aiua-13955	150	1	competing	compete	VERB
aiua-13955	150	2	interests	interest	NOUN
aiua-13955	150	3	:	:	PUNCT
aiua-13955	150	4	the	the	DET
aiua-13955	150	5	authors	author	NOUN
aiua-13955	150	6	declare	declare	VERB
aiua-13955	150	7	no	no	DET
aiua-13955	150	8	potential	potential	ADJ
aiua-13955	150	9	conflict	conflict	NOUN
aiua-13955	150	10	of	of	ADP
aiua-13955	150	11	interest	interest	NOUN
aiua-13955	150	12	.	.	PUNCT
aiua-13955	151	1	funding	funding	NOUN
aiua-13955	151	2	:	:	PUNCT
aiua-13955	151	3	the	the	DET
aiua-13955	151	4	authors	author	NOUN
aiua-13955	151	5	report	report	VERB
aiua-13955	151	6	no	no	DET
aiua-13955	151	7	funding	funding	NOUN
aiua-13955	151	8	.	.	PUNCT
aiua-13955	152	1	authors	author	NOUN
aiua-13955	152	2	'	'	PART
aiua-13955	152	3	contributions	contribution	NOUN
aiua-13955	152	4	:	:	PUNCT
aiua-13955	152	5	conception	conception	NOUN
aiua-13955	152	6	or	or	CCONJ
aiua-13955	152	7	design	design	NOUN
aiua-13955	152	8	:	:	PUNCT
aiua-13955	152	9	tnb	tnb	PROPN
aiua-13955	152	10	,	,	PUNCT
aiua-13955	152	11	kps	kps	PROPN
aiua-13955	152	12	;	;	PUNCT
aiua-13955	152	13	acquisition	acquisition	NOUN
aiua-13955	152	14	,	,	PUNCT
aiua-13955	152	15	analysis	analysis	NOUN
aiua-13955	152	16	,	,	PUNCT
aiua-13955	152	17	or	or	CCONJ
aiua-13955	152	18	interpretation	interpretation	NOUN
aiua-13955	152	19	of	of	ADP
aiua-13955	152	20	data	datum	NOUN
aiua-13955	152	21	:	:	PUNCT
aiua-13955	152	22	hnw	hnw	ADJ
aiua-13955	152	23	,	,	PUNCT
aiua-13955	152	24	arp	arp	ADJ
aiua-13955	152	25	,	,	PUNCT
aiua-13955	152	26	tnb	tnb	PROPN
aiua-13955	152	27	,	,	PUNCT
aiua-13955	152	28	kps	kps	PROPN
aiua-13955	152	29	;	;	PUNCT
aiua-13955	152	30	drafting	draft	VERB
aiua-13955	152	31	the	the	DET
aiua-13955	152	32	work	work	NOUN
aiua-13955	152	33	or	or	CCONJ
aiua-13955	152	34	revising	revise	VERB
aiua-13955	152	35	:	:	PUNCT
aiua-13955	152	36	hnw	hnw	ADJ
aiua-13955	152	37	,	,	PUNCT
aiua-13955	152	38	arp	arp	ADJ
aiua-13955	152	39	,	,	PUNCT
aiua-13955	152	40	tnb	tnb	PROPN
aiua-13955	152	41	,	,	PUNCT
aiua-13955	152	42	kps	kps	PROPN
aiua-13955	152	43	;	;	PUNCT
aiua-13955	152	44	final	final	ADJ
aiua-13955	152	45	approval	approval	NOUN
aiua-13955	152	46	of	of	ADP
aiua-13955	152	47	the	the	DET
aiua-13955	152	48	manuscript	manuscript	NOUN
aiua-13955	152	49	:	:	PUNCT
aiua-13955	152	50	hnw	hnw	ADJ
aiua-13955	152	51	,	,	PUNCT
aiua-13955	152	52	arp	arp	ADJ
aiua-13955	152	53	,	,	PUNCT
aiua-13955	152	54	tnb	tnb	PROPN
aiua-13955	152	55	,	,	PUNCT
aiua-13955	152	56	kps	kps	PROPN
aiua-13955	152	57	.	.	PUNCT
aiua-13955	153	1	archivio	archivio	PROPN
aiua-13955	153	2	italiano	italiano	PROPN
aiua-13955	153	3	di	di	PROPN
aiua-13955	153	4	urologia	urologia	PROPN
aiua-13955	153	5	e	e	PROPN
aiua-13955	153	6	andrologia	andrologia	NOUN
aiua-13955	153	7	2025	2025	NUM
aiua-13955	153	8	;	;	PUNCT
aiua-13955	153	9	97(3):13955	97(3):13955	NUM
aiua-13955	153	10	h.	h.	NOUN
aiua-13955	153	11	nindito	nindito	PROPN
aiua-13955	153	12	wicaksono	wicaksono	PROPN
aiua-13955	153	13	,	,	PUNCT
aiua-13955	153	14	t.	t.	PROPN
aiua-13955	153	15	nur	nur	PROPN
aiua-13955	153	16	budaya	budaya	PROPN
aiua-13955	153	17	,	,	PUNCT
aiua-13955	153	18	k.	k.	PROPN
aiua-13955	153	19	penta	penta	PROPN
aiua-13955	153	20	seputra	seputra	PROPN
aiua-13955	153	21	,	,	PUNCT
aiua-13955	153	22	a.	a.	PROPN
aiua-13955	153	23	rahman	rahman	PROPN
aiua-13955	153	24	putra	putra	PROPN
aiua-13955	153	25	6	6	NUM
aiua-13955	153	26	decreased	decrease	VERB
aiua-13955	153	27	survival	survival	NOUN
aiua-13955	153	28	in	in	ADP
aiua-13955	153	29	clear	clear	ADJ
aiua-13955	153	30	cell	cell	NOUN
aiua-13955	153	31	renal	renal	ADJ
aiua-13955	153	32	cell	cell	NOUN
aiua-13955	153	33	carcinoma	carcinoma	NOUN
aiua-13955	153	34	.	.	PUNCT
aiua-13955	154	1	cancers	cancer	NOUN
aiua-13955	154	2	(	(	PUNCT
aiua-13955	154	3	basel	basel	PROPN
aiua-13955	154	4	)	)	PUNCT
aiua-13955	154	5	2020	2020	NUM
aiua-13955	154	6	;	;	PUNCT
aiua-13955	154	7	12:1605	12:1605	X
aiua-13955	154	8	-	-	SYM
aiua-13955	154	9	15	15	NUM
aiua-13955	154	10	.	.	NOUN
aiua-13955	154	11	16	16	NUM
aiua-13955	154	12	.	.	PUNCT
aiua-13955	155	1	wang	wang	PROPN
aiua-13955	155	2	y	y	PROPN
aiua-13955	155	3	,	,	PUNCT
aiua-13955	155	4	zhang	zhang	PROPN
aiua-13955	155	5	y.	y.	PROPN
aiua-13955	155	6	prognostic	prognostic	ADJ
aiua-13955	155	7	role	role	NOUN
aiua-13955	155	8	of	of	ADP
aiua-13955	155	9	interleukin-6	interleukin-6	NUM
aiua-13955	155	10	in	in	ADP
aiua-13955	155	11	renal	renal	ADJ
aiua-13955	155	12	cell	cell	NOUN
aiua-13955	155	13	carcinoma	carcinoma	NOUN
aiua-13955	155	14	:	:	PUNCT
aiua-13955	155	15	a	a	DET
aiua-13955	155	16	meta	meta	ADJ
aiua-13955	155	17	-	-	PUNCT
aiua-13955	155	18	analysis	analysis	NOUN
aiua-13955	155	19	.	.	PUNCT
aiua-13955	156	1	clin	clin	PROPN
aiua-13955	156	2	transl	transl	PROPN
aiua-13955	156	3	oncol	oncol	PROPN
aiua-13955	156	4	2020	2020	NUM
aiua-13955	156	5	;	;	PUNCT
aiua-13955	156	6	22:835	22:835	NUM
aiua-13955	156	7	-	-	SYM
aiua-13955	156	8	43	43	NUM
aiua-13955	156	9	.	.	PUNCT
aiua-13955	156	10	17	17	NUM
aiua-13955	156	11	.	.	PUNCT
aiua-13955	157	1	gopinathan	gopinathan	PROPN
aiua-13955	157	2	g	g	PROPN
aiua-13955	157	3	,	,	PUNCT
aiua-13955	157	4	milagre	milagre	NOUN
aiua-13955	157	5	c	c	X
aiua-13955	157	6	,	,	PUNCT
aiua-13955	157	7	pearce	pearce	PROPN
aiua-13955	157	8	omt	omt	PROPN
aiua-13955	157	9	,	,	PUNCT
aiua-13955	157	10	et	et	PROPN
aiua-13955	157	11	al	al	PROPN
aiua-13955	157	12	.	.	PROPN
aiua-13955	158	1	interleukin-6	interleukin-6	PROPN
aiua-13955	158	2	stimulates	stimulate	VERB
aiua-13955	158	3	defective	defective	ADJ
aiua-13955	158	4	angiogenesis	angiogenesis	NOUN
aiua-13955	158	5	.	.	PUNCT
aiua-13955	159	1	cancer	cancer	NOUN
aiua-13955	159	2	res	re	NOUN
aiua-13955	159	3	2015	2015	NUM
aiua-13955	159	4	;	;	PUNCT
aiua-13955	159	5	75:3098	75:3098	NUM
aiua-13955	159	6	-	-	SYM
aiua-13955	159	7	107	107	NUM
aiua-13955	159	8	.	.	PUNCT
aiua-13955	160	1	18	18	NUM
aiua-13955	160	2	.	.	PUNCT
aiua-13955	161	1	jian	jian	PROPN
aiua-13955	161	2	y	y	PROPN
aiua-13955	161	3	,	,	PUNCT
aiua-13955	161	4	yang	yang	PROPN
aiua-13955	161	5	k	k	PROPN
aiua-13955	161	6	,	,	PUNCT
aiua-13955	161	7	sun	sun	PROPN
aiua-13955	161	8	x	x	AUX
aiua-13955	161	9	,	,	PUNCT
aiua-13955	161	10	et	et	PROPN
aiua-13955	161	11	al	al	PROPN
aiua-13955	161	12	.	.	PUNCT
aiua-13955	162	1	current	current	ADJ
aiua-13955	162	2	advance	advance	NOUN
aiua-13955	162	3	of	of	ADP
aiua-13955	162	4	immune	immune	ADJ
aiua-13955	162	5	evasion	evasion	NOUN
aiua-13955	162	6	mechanisms	mechanism	NOUN
aiua-13955	162	7	and	and	CCONJ
aiua-13955	162	8	emerging	emerge	VERB
aiua-13955	162	9	immunotherapies	immunotherapy	NOUN
aiua-13955	162	10	in	in	ADP
aiua-13955	162	11	renal	renal	ADJ
aiua-13955	162	12	cell	cell	NOUN
aiua-13955	162	13	carcinoma	carcinoma	NOUN
aiua-13955	162	14	.	.	PUNCT
aiua-13955	163	1	front	front	ADJ
aiua-13955	163	2	.	.	PUNCT
aiua-13955	164	1	immunol	immunol	NOUN
aiua-13955	164	2	.	.	PUNCT
aiua-13955	165	1	2021	2021	NUM
aiua-13955	165	2	;	;	PUNCT
aiua-13955	166	1	12:1	12:1	NUM
aiua-13955	166	2	-	-	SYM
aiua-13955	166	3	21	21	NUM
aiua-13955	166	4	.	.	PUNCT
aiua-13955	167	1	19	19	NUM
aiua-13955	167	2	.	.	PUNCT
aiua-13955	167	3	ishibashi	ishibashi	PROPN
aiua-13955	167	4	k	k	PROPN
aiua-13955	167	5	,	,	PUNCT
aiua-13955	167	6	koguchi	koguchi	PROPN
aiua-13955	167	7	t	t	PROPN
aiua-13955	167	8	,	,	PUNCT
aiua-13955	167	9	matsuoka	matsuoka	VERB
aiua-13955	167	10	k	k	PROPN
aiua-13955	167	11	,	,	PUNCT
aiua-13955	167	12	et	et	PROPN
aiua-13955	167	13	al	al	PROPN
aiua-13955	167	14	.	.	PROPN
aiua-13955	168	1	interleukin-6	interleukin-6	PROPN
aiua-13955	168	2	induces	induce	VERB
aiua-13955	168	3	drug	drug	NOUN
aiua-13955	168	4	resistance	resistance	NOUN
aiua-13955	168	5	in	in	ADP
aiua-13955	168	6	renal	renal	ADJ
aiua-13955	168	7	cell	cell	NOUN
aiua-13955	168	8	carcinoma	carcinoma	NOUN
aiua-13955	168	9	.	.	PUNCT
aiua-13955	169	1	fukushima	fukushima	PROPN
aiua-13955	169	2	j.	j.	PROPN
aiua-13955	169	3	med	med	PROPN
aiua-13955	169	4	.	.	PUNCT
aiua-13955	170	1	sci	sci	PROPN
aiua-13955	170	2	.	.	PROPN
aiua-13955	170	3	2018	2018	NUM
aiua-13955	170	4	;	;	PUNCT
aiua-13955	170	5	64:103	64:103	NOUN
aiua-13955	170	6	-	-	SYM
aiua-13955	170	7	10	10	NUM
aiua-13955	170	8	.	.	PUNCT
aiua-13955	170	9	20	20	NUM
aiua-13955	170	10	.	.	PUNCT
aiua-13955	171	1	soler	soler	PROPN
aiua-13955	171	2	mf	mf	PROPN
aiua-13955	171	3	,	,	PUNCT
aiua-13955	171	4	abaurrea	abaurrea	NOUN
aiua-13955	171	5	a	a	PRON
aiua-13955	171	6	,	,	PUNCT
aiua-13955	171	7	azcoaga	azcoaga	PROPN
aiua-13955	171	8	p	p	NOUN
aiua-13955	171	9	,	,	PUNCT
aiua-13955	171	10	et	et	PROPN
aiua-13955	171	11	al	al	PROPN
aiua-13955	171	12	.	.	PUNCT
aiua-13955	172	1	new	new	ADJ
aiua-13955	172	2	perspectives	perspective	NOUN
aiua-13955	172	3	in	in	ADP
aiua-13955	172	4	cancer	cancer	NOUN
aiua-13955	172	5	immunotherapy	immunotherapy	NOUN
aiua-13955	172	6	:	:	PUNCT
aiua-13955	172	7	targeting	target	VERB
aiua-13955	172	8	il-6	il-6	NUM
aiua-13955	172	9	cytokine	cytokine	NOUN
aiua-13955	172	10	family	family	NOUN
aiua-13955	172	11	.	.	PUNCT
aiua-13955	173	1	j.	j.	PROPN
aiua-13955	173	2	immunother	immunother	PROPN
aiua-13955	173	3	.	.	PUNCT
aiua-13955	174	1	cancer	cancer	NOUN
aiua-13955	174	2	2023	2023	NUM
aiua-13955	174	3	;	;	PUNCT
aiua-13955	174	4	11:1	11:1	NUM
aiua-13955	174	5	-	-	SYM
aiua-13955	174	6	13	13	NUM
aiua-13955	174	7	.	.	PUNCT
aiua-13955	174	8	21	21	NUM
aiua-13955	174	9	.	.	PUNCT
aiua-13955	175	1	sweeney	sweeney	PROPN
aiua-13955	175	2	pl	pl	PROPN
aiua-13955	175	3	,	,	PUNCT
aiua-13955	175	4	suri	suri	PROPN
aiua-13955	175	5	y	y	PROPN
aiua-13955	175	6	,	,	PUNCT
aiua-13955	175	7	basu	basu	PROPN
aiua-13955	175	8	a	a	PROPN
aiua-13955	175	9	,	,	PUNCT
aiua-13955	175	10	et	et	PROPN
aiua-13955	175	11	al	al	PROPN
aiua-13955	175	12	.	.	PROPN
aiua-13955	175	13	mechanisms	mechanism	NOUN
aiua-13955	175	14	of	of	ADP
aiua-13955	175	15	tyrosine	tyrosine	PROPN
aiua-13955	175	16	kinase	kinase	PROPN
aiua-13955	175	17	inhibitor	inhibitor	PROPN
aiua-13955	175	18	resistance	resistance	NOUN
aiua-13955	175	19	in	in	ADP
aiua-13955	175	20	renal	renal	ADJ
aiua-13955	175	21	cell	cell	NOUN
aiua-13955	175	22	carcinoma	carcinoma	NOUN
aiua-13955	175	23	.	.	PUNCT
aiua-13955	176	1	cancer	cancer	NOUN
aiua-13955	176	2	drug	drug	NOUN
aiua-13955	176	3	resist.2023	resist.2023	PROPN
aiua-13955	176	4	;	;	PUNCT
aiua-13955	176	5	6:858	6:858	NUM
aiua-13955	176	6	-	-	SYM
aiua-13955	176	7	73	73	NUM
aiua-13955	176	8	.	.	PUNCT
aiua-13955	177	1	correspondence	correspondence	NOUN
aiua-13955	177	2	haryo	haryo	PROPN
aiua-13955	177	3	nindito	nindito	PROPN
aiua-13955	177	4	wicaksono	wicaksono	PROPN
aiua-13955	177	5	(	(	PUNCT
aiua-13955	177	6	corresponding	correspond	VERB
aiua-13955	177	7	author	author	NOUN
aiua-13955	177	8	)	)	PUNCT
aiua-13955	177	9	wicaksonoharyo123@gmail.com	wicaksonoharyo123@gmail.com	X
aiua-13955	177	10	general	general	ADJ
aiua-13955	177	11	practicioner	practicioner	NOUN
aiua-13955	177	12	,	,	PUNCT
aiua-13955	177	13	intern	intern	NOUN
aiua-13955	177	14	at	at	ADP
aiua-13955	177	15	department	department	PROPN
aiua-13955	177	16	of	of	ADP
aiua-13955	177	17	urology	urology	NOUN
aiua-13955	177	18	,	,	PUNCT
aiua-13955	177	19	faculty	faculty	NOUN
aiua-13955	177	20	of	of	ADP
aiua-13955	177	21	medicine	medicine	NOUN
aiua-13955	177	22	,	,	PUNCT
aiua-13955	177	23	universitas	universita	NOUN
aiua-13955	177	24	brawijaya	brawijaya	NOUN
aiua-13955	177	25	,	,	PUNCT
aiua-13955	177	26	saiful	saiful	PROPN
aiua-13955	177	27	anwar	anwar	PROPN
aiua-13955	177	28	general	general	PROPN
aiua-13955	177	29	hospital	hospital	PROPN
aiua-13955	177	30	,	,	PUNCT
aiua-13955	177	31	malang	malang	PROPN
aiua-13955	177	32	,	,	PUNCT
aiua-13955	177	33	indonesia	indonesia	PROPN
aiua-13955	177	34	aulia	aulia	PROPN
aiua-13955	177	35	rahman	rahman	PROPN
aiua-13955	177	36	putra	putra	PROPN
aiua-13955	177	37	taufiq	taufiq	PROPN
aiua-13955	177	38	nur	nur	PROPN
aiua-13955	177	39	budaya	budaya	PROPN
aiua-13955	177	40	kurnia	kurnia	PROPN
aiua-13955	177	41	penta	penta	PROPN
aiua-13955	177	42	seputra	seputra	PROPN
aiua-13955	177	43	department	department	PROPN
aiua-13955	177	44	of	of	ADP
aiua-13955	177	45	urology	urology	NOUN
aiua-13955	177	46	,	,	PUNCT
aiua-13955	177	47	faculty	faculty	NOUN
aiua-13955	177	48	of	of	ADP
aiua-13955	177	49	medicine	medicine	NOUN
aiua-13955	177	50	,	,	PUNCT
aiua-13955	177	51	universitas	universita	NOUN
aiua-13955	177	52	brawijaya	brawijaya	NOUN
aiua-13955	177	53	,	,	PUNCT
aiua-13955	177	54	saiful	saiful	PROPN
aiua-13955	177	55	anwar	anwar	PROPN
aiua-13955	177	56	general	general	PROPN
aiua-13955	177	57	hospital	hospital	PROPN
aiua-13955	177	58	,	,	PUNCT
aiua-13955	177	59	malang	malang	PROPN
aiua-13955	177	60	,	,	PUNCT
aiua-13955	177	61	indonesia	indonesia	PROPN