id	sid	tid	token	lemma	pos
aiua-5924	1	1	stesura	stesura	PROPN
aiua-5924	1	2	seveso	seveso	PROPN
aiua-5924	1	3	archivio	archivio	PROPN
aiua-5924	1	4	italiano	italiano	X
aiua-5924	1	5	di	di	X
aiua-5924	1	6	urologia	urologia	PROPN
aiua-5924	1	7	e	e	PROPN
aiua-5924	1	8	andrologia	andrologia	NOUN
aiua-5924	1	9	2016	2016	NUM
aiua-5924	1	10	;	;	PUNCT
aiua-5924	1	11	88	88	NUM
aiua-5924	1	12	,	,	PUNCT
aiua-5924	1	13	174	174	NUM
aiua-5924	1	14	no	no	DET
aiua-5924	1	15	conflict	conflict	NOUN
aiua-5924	1	16	of	of	ADP
aiua-5924	1	17	interest	interest	NOUN
aiua-5924	1	18	declared	declare	VERB
aiua-5924	1	19	.	.	PUNCT
aiua-5924	2	1	doi	doi	NOUN
aiua-5924	2	2	:	:	PUNCT
aiua-5924	2	3	10.4081	10.4081	NUM
aiua-5924	2	4	/	/	SYM
aiua-5924	2	5	aiua.2016.1.74	aiua.2016.1.74	PROPN
aiua-5924	2	6	reply	reply	NOUN
aiua-5924	2	7	to	to	ADP
aiua-5924	2	8	:	:	PUNCT
aiua-5924	2	9	clarification	clarification	NOUN
aiua-5924	2	10	to	to	PART
aiua-5924	2	11	provide	provide	VERB
aiua-5924	2	12	further	further	ADJ
aiua-5924	2	13	understanding	understanding	NOUN
aiua-5924	2	14	of	of	ADP
aiua-5924	2	15	the	the	DET
aiua-5924	2	16	conduct	conduct	NOUN
aiua-5924	2	17	and	and	CCONJ
aiua-5924	2	18	design	design	NOUN
aiua-5924	2	19	of	of	ADP
aiua-5924	2	20	tropic	tropic	NOUN
aiua-5924	2	21	:	:	PUNCT
aiua-5924	2	22	a	a	DET
aiua-5924	2	23	phase	phase	NOUN
aiua-5924	2	24	3	3	NUM
aiua-5924	2	25	trial	trial	NOUN
aiua-5924	2	26	of	of	ADP
aiua-5924	2	27	cabazitaxel	cabazitaxel	PROPN
aiua-5924	2	28	versus	versus	ADP
aiua-5924	2	29	mitoxantrone	mitoxantrone	NOUN
aiua-5924	2	30	in	in	ADP
aiua-5924	2	31	patients	patient	NOUN
aiua-5924	2	32	with	with	ADP
aiua-5924	2	33	metastatic	metastatic	ADJ
aiua-5924	2	34	castration	castration	NOUN
aiua-5924	2	35	-	-	PUNCT
aiua-5924	2	36	resistant	resistant	ADJ
aiua-5924	2	37	prostate	prostate	NOUN
aiua-5924	2	38	cancer	cancer	NOUN
aiua-5924	2	39	dear	dear	ADJ
aiua-5924	2	40	editors	editor	NOUN
aiua-5924	2	41	,	,	PUNCT
aiua-5924	2	42	thank	thank	VERB
aiua-5924	2	43	you	you	PRON
aiua-5924	2	44	for	for	ADP
aiua-5924	2	45	bringing	bring	VERB
aiua-5924	2	46	to	to	ADP
aiua-5924	2	47	our	our	PRON
aiua-5924	2	48	attention	attention	NOUN
aiua-5924	2	49	the	the	DET
aiua-5924	2	50	letter	letter	NOUN
aiua-5924	2	51	from	from	ADP
aiua-5924	2	52	johann	johann	PROPN
aiua-5924	2	53	de	de	X
aiua-5924	2	54	bono	bono	X
aiua-5924	2	55	,	,	PUNCT
aiua-5924	2	56	liji	liji	PROPN
aiua-5924	2	57	shen	shen	PROPN
aiua-5924	2	58	and	and	CCONJ
aiua-5924	2	59	oliver	oliver	PROPN
aiua-5924	2	60	sartor	sartor	PROPN
aiua-5924	2	61	concerning	concern	VERB
aiua-5924	2	62	our	our	PRON
aiua-5924	2	63	article	article	NOUN
aiua-5924	2	64	entitled	entitle	VERB
aiua-5924	2	65	“	"	PUNCT
aiua-5924	2	66	efficacy	efficacy	NOUN
aiua-5924	2	67	and	and	CCONJ
aiua-5924	2	68	safety	safety	NOUN
aiua-5924	2	69	of	of	ADP
aiua-5924	2	70	second	second	ADJ
aiua-5924	2	71	-	-	PUNCT
aiua-5924	2	72	line	line	NOUN
aiua-5924	2	73	agents	agent	NOUN
aiua-5924	2	74	for	for	ADP
aiua-5924	2	75	treatment	treatment	NOUN
aiua-5924	2	76	of	of	ADP
aiua-5924	2	77	metastatic	metastatic	ADJ
aiua-5924	2	78	castration	castration	NOUN
aiua-5924	2	79	-	-	PUNCT
aiua-5924	2	80	resistant	resistant	ADJ
aiua-5924	2	81	prostate	prostate	NOUN
aiua-5924	2	82	cancer	cancer	NOUN
aiua-5924	2	83	progressing	progressing	NOUN
aiua-5924	2	84	after	after	ADP
aiua-5924	2	85	docetaxel	docetaxel	NOUN
aiua-5924	2	86	.	.	PUNCT
aiua-5924	3	1	a	a	DET
aiua-5924	3	2	systematic	systematic	ADJ
aiua-5924	3	3	review	review	NOUN
aiua-5924	3	4	and	and	CCONJ
aiua-5924	3	5	meta	meta	ADJ
aiua-5924	3	6	-	-	PUNCT
aiua-5924	3	7	analysis	analysis	NOUN
aiua-5924	3	8	”	"	PUNCT
aiua-5924	3	9	published	publish	VERB
aiua-5924	3	10	in	in	ADP
aiua-5924	3	11	the	the	DET
aiua-5924	3	12	archivio	archivio	NOUN
aiua-5924	3	13	italiano	italiano	X
aiua-5924	3	14	di	di	X
aiua-5924	3	15	urologia	urologia	PROPN
aiua-5924	3	16	e	e	NOUN
aiua-5924	3	17	andrologia	andrologia	NOUN
aiua-5924	3	18	.	.	PUNCT
aiua-5924	4	1	we	we	PRON
aiua-5924	4	2	wish	wish	VERB
aiua-5924	4	3	to	to	PART
aiua-5924	4	4	thank	thank	VERB
aiua-5924	4	5	johann	johann	PROPN
aiua-5924	4	6	de	de	X
aiua-5924	4	7	bono	bono	X
aiua-5924	4	8	,	,	PUNCT
aiua-5924	4	9	liji	liji	PROPN
aiua-5924	4	10	shen	shen	PROPN
aiua-5924	4	11	and	and	CCONJ
aiua-5924	4	12	oliver	oliver	PROPN
aiua-5924	4	13	sartor	sartor	PROPN
aiua-5924	4	14	for	for	ADP
aiua-5924	4	15	their	their	PRON
aiua-5924	4	16	interest	interest	NOUN
aiua-5924	4	17	in	in	ADP
aiua-5924	4	18	our	our	PRON
aiua-5924	4	19	work	work	NOUN
aiua-5924	4	20	and	and	CCONJ
aiua-5924	4	21	we	we	PRON
aiua-5924	4	22	are	be	AUX
aiua-5924	4	23	grateful	grateful	ADJ
aiua-5924	4	24	to	to	ADP
aiua-5924	4	25	the	the	DET
aiua-5924	4	26	editors	editor	NOUN
aiua-5924	4	27	for	for	ADP
aiua-5924	4	28	giving	give	VERB
aiua-5924	4	29	us	we	PRON
aiua-5924	4	30	the	the	DET
aiua-5924	4	31	opportunity	opportunity	NOUN
aiua-5924	4	32	to	to	PART
aiua-5924	4	33	respond	respond	VERB
aiua-5924	4	34	to	to	ADP
aiua-5924	4	35	their	their	PRON
aiua-5924	4	36	comments	comment	NOUN
aiua-5924	4	37	and	and	CCONJ
aiua-5924	4	38	remarks	remark	NOUN
aiua-5924	4	39	.	.	PUNCT
aiua-5924	5	1	perletti	perletti	NOUN
aiua-5924	5	2	and	and	CCONJ
aiua-5924	5	3	co	co	NOUN
aiua-5924	5	4	-	-	NOUN
aiua-5924	5	5	authors	author	NOUN
aiua-5924	5	6	’	'	PUNCT
aiua-5924	5	7	response	response	NOUN
aiua-5924	5	8	(	(	PUNCT
aiua-5924	5	9	row	row	NOUN
aiua-5924	5	10	1	1	NUM
aiua-5924	5	11	):	):	PUNCT
aiua-5924	5	12	according	accord	VERB
aiua-5924	5	13	to	to	ADP
aiua-5924	5	14	cochrane	cochrane	NOUN
aiua-5924	5	15	standards	standard	NOUN
aiua-5924	5	16	,	,	PUNCT
aiua-5924	5	17	risk	risk	NOUN
aiua-5924	5	18	of	of	ADP
aiua-5924	5	19	bias	bias	NOUN
aiua-5924	5	20	is	be	AUX
aiua-5924	5	21	“	"	PUNCT
aiua-5924	5	22	unclear	unclear	ADJ
aiua-5924	5	23	”	"	PUNCT
aiua-5924	5	24	when	when	SCONJ
aiua-5924	5	25	the	the	DET
aiua-5924	5	26	available	available	ADJ
aiua-5924	5	27	information	information	NOUN
aiua-5924	5	28	is	be	AUX
aiua-5924	5	29	insufficient	insufficient	ADJ
aiua-5924	5	30	to	to	PART
aiua-5924	5	31	allow	allow	VERB
aiua-5924	5	32	evaluation	evaluation	NOUN
aiua-5924	5	33	of	of	ADP
aiua-5924	5	34	the	the	DET
aiua-5924	5	35	risk	risk	NOUN
aiua-5924	5	36	.	.	PUNCT
aiua-5924	6	1	the	the	DET
aiua-5924	6	2	fact	fact	NOUN
aiua-5924	6	3	that	that	SCONJ
aiua-5924	6	4	dynamic	dynamic	ADJ
aiua-5924	6	5	allocation	allocation	NOUN
aiua-5924	6	6	was	be	AUX
aiua-5924	6	7	instigated	instigate	VERB
aiua-5924	6	8	in	in	ADP
aiua-5924	6	9	few	few	ADJ
aiua-5924	6	10	occasions	occasion	NOUN
aiua-5924	6	11	in	in	ADP
aiua-5924	6	12	the	the	DET
aiua-5924	6	13	tropic	tropic	NOUN
aiua-5924	6	14	trial	trial	NOUN
aiua-5924	6	15	makes	make	VERB
aiua-5924	6	16	the	the	DET
aiua-5924	6	17	risk	risk	NOUN
aiua-5924	6	18	of	of	ADP
aiua-5924	6	19	selection	selection	NOUN
aiua-5924	6	20	bias	bias	NOUN
aiua-5924	6	21	difficult	difficult	ADJ
aiua-5924	6	22	to	to	PART
aiua-5924	6	23	evaluate	evaluate	VERB
aiua-5924	6	24	.	.	PUNCT
aiua-5924	7	1	in	in	ADP
aiua-5924	7	2	this	this	DET
aiua-5924	7	3	respect	respect	NOUN
aiua-5924	7	4	,	,	PUNCT
aiua-5924	7	5	a	a	DET
aiua-5924	7	6	tradeoff	tradeoff	NOUN
aiua-5924	7	7	between	between	ADP
aiua-5924	7	8	balance	balance	NOUN
aiua-5924	7	9	and	and	CCONJ
aiua-5924	7	10	predictability	predictability	NOUN
aiua-5924	7	11	is	be	AUX
aiua-5924	7	12	a	a	DET
aiua-5924	7	13	constitutive	constitutive	ADJ
aiua-5924	7	14	component	component	NOUN
aiua-5924	7	15	of	of	ADP
aiua-5924	7	16	dynamic	dynamic	ADJ
aiua-5924	7	17	allocation	allocation	NOUN
aiua-5924	7	18	strategies	strategy	NOUN
aiua-5924	7	19	.	.	PUNCT
aiua-5924	8	1	perletti	perletti	NOUN
aiua-5924	8	2	and	and	CCONJ
aiua-5924	8	3	co	co	NOUN
aiua-5924	8	4	-	-	NOUN
aiua-5924	8	5	authors	author	NOUN
aiua-5924	8	6	’	'	PUNCT
aiua-5924	8	7	response	response	NOUN
aiua-5924	8	8	(	(	PUNCT
aiua-5924	8	9	row	row	NOUN
aiua-5924	8	10	2	2	NUM
aiua-5924	8	11	):	):	PUNCT
aiua-5924	8	12	when	when	SCONJ
aiua-5924	8	13	the	the	DET
aiua-5924	8	14	study	study	NOUN
aiua-5924	8	15	protocol	protocol	NOUN
aiua-5924	8	16	is	be	AUX
aiua-5924	8	17	not	not	PART
aiua-5924	8	18	available	available	ADJ
aiua-5924	8	19	together	together	ADV
aiua-5924	8	20	with	with	ADP
aiua-5924	8	21	the	the	DET
aiua-5924	8	22	study	study	NOUN
aiua-5924	8	23	article	article	NOUN
aiua-5924	8	24	(	(	PUNCT
aiua-5924	8	25	protocols	protocol	NOUN
aiua-5924	8	26	were	be	AUX
aiua-5924	8	27	provided	provide	VERB
aiua-5924	8	28	as	as	ADP
aiua-5924	8	29	online	online	ADJ
aiua-5924	8	30	supplementary	supplementary	ADJ
aiua-5924	8	31	material	material	NOUN
aiua-5924	8	32	of	of	ADP
aiua-5924	8	33	the	the	DET
aiua-5924	8	34	affirm	affirm	NOUN
aiua-5924	8	35	and	and	CCONJ
aiua-5924	8	36	cou	cou	PROPN
aiua-5924	8	37	-	-	PUNCT
aiua-5924	8	38	aa-301	aa-301	NOUN
aiua-5924	8	39	reports	report	NOUN
aiua-5924	8	40	)	)	PUNCT
aiua-5924	8	41	,	,	PUNCT
aiua-5924	8	42	or	or	CCONJ
aiua-5924	8	43	elsewhere	elsewhere	ADV
aiua-5924	8	44	in	in	ADP
aiua-5924	8	45	the	the	DET
aiua-5924	8	46	internet	internet	NOUN
aiua-5924	8	47	,	,	PUNCT
aiua-5924	8	48	the	the	DET
aiua-5924	8	49	evaluation	evaluation	NOUN
aiua-5924	8	50	of	of	ADP
aiua-5924	8	51	the	the	DET
aiua-5924	8	52	risk	risk	NOUN
aiua-5924	8	53	of	of	ADP
aiua-5924	8	54	bias	bias	NOUN
aiua-5924	8	55	becomes	become	VERB
aiua-5924	8	56	more	more	ADV
aiua-5924	8	57	difficult	difficult	ADJ
aiua-5924	8	58	and	and	CCONJ
aiua-5924	8	59	the	the	DET
aiua-5924	8	60	level	level	NOUN
aiua-5924	8	61	of	of	ADP
aiua-5924	8	62	uncertainty	uncertainty	NOUN
aiua-5924	8	63	naturally	naturally	ADV
aiua-5924	8	64	increases	increase	VERB
aiua-5924	8	65	.	.	PUNCT
aiua-5924	9	1	the	the	DET
aiua-5924	9	2	risk	risk	NOUN
aiua-5924	9	3	of	of	ADP
aiua-5924	9	4	misinterpretation	misinterpretation	NOUN
aiua-5924	9	5	also	also	ADV
aiua-5924	9	6	increases	increase	VERB
aiua-5924	9	7	when	when	SCONJ
aiua-5924	9	8	a	a	DET
aiua-5924	9	9	journal	journal	NOUN
aiua-5924	9	10	sets	set	VERB
aiua-5924	9	11	a	a	DET
aiua-5924	9	12	strict	strict	ADJ
aiua-5924	9	13	word	word	NOUN
aiua-5924	9	14	count	count	NOUN
aiua-5924	9	15	limit	limit	NOUN
aiua-5924	9	16	for	for	ADP
aiua-5924	9	17	the	the	DET
aiua-5924	9	18	text	text	NOUN
aiua-5924	9	19	of	of	ADP
aiua-5924	9	20	a	a	DET
aiua-5924	9	21	trial	trial	NOUN
aiua-5924	9	22	report	report	NOUN
aiua-5924	9	23	of	of	ADP
aiua-5924	9	24	considerable	considerable	ADJ
aiua-5924	9	25	importance	importance	NOUN
aiua-5924	9	26	,	,	PUNCT
aiua-5924	9	27	and	and	CCONJ
aiua-5924	9	28	important	important	ADJ
aiua-5924	9	29	information	information	NOUN
aiua-5924	9	30	is	be	AUX
aiua-5924	9	31	presented	present	VERB
aiua-5924	9	32	in	in	ADP
aiua-5924	9	33	a	a	DET
aiua-5924	9	34	very	very	ADV
aiua-5924	9	35	synthetic	synthetic	ADJ
aiua-5924	9	36	form	form	NOUN
aiua-5924	9	37	.	.	PUNCT
aiua-5924	10	1	perletti	perletti	NOUN
aiua-5924	10	2	and	and	CCONJ
aiua-5924	10	3	co	co	NOUN
aiua-5924	10	4	-	-	NOUN
aiua-5924	10	5	authors	author	NOUN
aiua-5924	10	6	’	'	PUNCT
aiua-5924	10	7	response	response	NOUN
aiua-5924	10	8	(	(	PUNCT
aiua-5924	10	9	row	row	NOUN
aiua-5924	10	10	3	3	NUM
aiua-5924	10	11	):	):	PUNCT
aiua-5924	10	12	although	although	SCONJ
aiua-5924	10	13	quality	quality	NOUN
aiua-5924	10	14	of	of	ADP
aiua-5924	10	15	life	life	NOUN
aiua-5924	10	16	data	datum	NOUN
aiua-5924	10	17	were	be	AUX
aiua-5924	10	18	not	not	PART
aiua-5924	10	19	collected	collect	VERB
aiua-5924	10	20	,	,	PUNCT
aiua-5924	10	21	pain	pain	NOUN
aiua-5924	10	22	was	be	AUX
aiua-5924	10	23	an	an	DET
aiua-5924	10	24	important	important	ADJ
aiua-5924	10	25	component	component	NOUN
aiua-5924	10	26	of	of	ADP
aiua-5924	10	27	the	the	DET
aiua-5924	10	28	composite	composite	ADJ
aiua-5924	10	29	pfs	pfs	NOUN
aiua-5924	10	30	endpoint	endpoint	NOUN
aiua-5924	10	31	of	of	ADP
aiua-5924	10	32	tropic	tropic	NOUN
aiua-5924	10	33	.	.	PUNCT
aiua-5924	11	1	pain	pain	NOUN
aiua-5924	11	2	is	be	AUX
aiua-5924	11	3	the	the	DET
aiua-5924	11	4	typical	typical	ADJ
aiua-5924	11	5	endpoint	endpoint	NOUN
aiua-5924	11	6	that	that	PRON
aiua-5924	11	7	may	may	AUX
aiua-5924	11	8	be	be	AUX
aiua-5924	11	9	substantially	substantially	ADV
aiua-5924	11	10	biased	biased	ADJ
aiua-5924	11	11	when	when	SCONJ
aiua-5924	11	12	patients	patient	NOUN
aiua-5924	11	13	are	be	AUX
aiua-5924	11	14	unblinded	unblinded	ADJ
aiua-5924	11	15	to	to	ADP
aiua-5924	11	16	their	their	PRON
aiua-5924	11	17	treatment	treatment	NOUN
aiua-5924	11	18	allocation	allocation	NOUN
aiua-5924	11	19	.	.	PUNCT
aiua-5924	12	1	perletti	perletti	PROPN
aiua-5924	12	2	and	and	CCONJ
aiua-5924	12	3	co	co	NOUN
aiua-5924	12	4	-	-	NOUN
aiua-5924	12	5	authors	author	NOUN
aiua-5924	12	6	’	'	PUNCT
aiua-5924	12	7	response	response	NOUN
aiua-5924	12	8	(	(	PUNCT
aiua-5924	12	9	row	row	NOUN
aiua-5924	12	10	5	5	NUM
aiua-5924	12	11	):	):	PUNCT
aiua-5924	12	12	unclear	unclear	ADJ
aiua-5924	12	13	risk	risk	NOUN
aiua-5924	12	14	of	of	ADP
aiua-5924	12	15	bias	bias	NOUN
aiua-5924	12	16	does	do	AUX
aiua-5924	12	17	not	not	PART
aiua-5924	12	18	represent	represent	VERB
aiua-5924	12	19	a	a	DET
aiua-5924	12	20	negative	negative	ADJ
aiua-5924	12	21	evaluation	evaluation	NOUN
aiua-5924	12	22	of	of	ADP
aiua-5924	12	23	the	the	DET
aiua-5924	12	24	quality	quality	NOUN
aiua-5924	12	25	of	of	ADP
aiua-5924	12	26	the	the	DET
aiua-5924	12	27	evidence	evidence	NOUN
aiua-5924	12	28	.	.	PUNCT
aiua-5924	13	1	simply	simply	ADV
aiua-5924	13	2	,	,	PUNCT
aiua-5924	13	3	the	the	DET
aiua-5924	13	4	assessors	assessor	NOUN
aiua-5924	13	5	are	be	AUX
aiua-5924	13	6	waiving	waive	VERB
aiua-5924	13	7	any	any	DET
aiua-5924	13	8	evaluation	evaluation	NOUN
aiua-5924	13	9	of	of	ADP
aiua-5924	13	10	the	the	DET
aiua-5924	13	11	risk	risk	NOUN
aiua-5924	13	12	of	of	ADP
aiua-5924	13	13	bias	bias	NOUN
aiua-5924	13	14	when	when	SCONJ
aiua-5924	13	15	full	full	ADJ
aiua-5924	13	16	assessment	assessment	NOUN
aiua-5924	13	17	is	be	AUX
aiua-5924	13	18	hampered	hamper	VERB
aiua-5924	13	19	by	by	ADP
aiua-5924	13	20	lack	lack	NOUN
aiua-5924	13	21	of	of	ADP
aiua-5924	13	22	information	information	NOUN
aiua-5924	13	23	,	,	PUNCT
aiua-5924	13	24	ambiguity	ambiguity	NOUN
aiua-5924	13	25	,	,	PUNCT
aiua-5924	13	26	or	or	CCONJ
aiua-5924	13	27	any	any	DET
aiua-5924	13	28	other	other	ADJ
aiua-5924	13	29	factor	factor	NOUN
aiua-5924	13	30	making	make	VERB
aiua-5924	13	31	it	it	PRON
aiua-5924	13	32	difficult	difficult	ADJ
aiua-5924	13	33	to	to	PART
aiua-5924	13	34	assign	assign	VERB
aiua-5924	13	35	the	the	DET
aiua-5924	13	36	score	score	NOUN
aiua-5924	13	37	“	"	PUNCT
aiua-5924	13	38	low	low	ADJ
aiua-5924	13	39	”	"	PUNCT
aiua-5924	13	40	or	or	CCONJ
aiua-5924	13	41	“	"	PUNCT
aiua-5924	13	42	high	high	ADJ
aiua-5924	13	43	”	"	PUNCT
aiua-5924	13	44	to	to	ADP
aiua-5924	13	45	a	a	DET
aiua-5924	13	46	specific	specific	ADJ
aiua-5924	13	47	item	item	NOUN
aiua-5924	13	48	in	in	ADP
aiua-5924	13	49	the	the	DET
aiua-5924	13	50	rob	rob	PROPN
aiua-5924	13	51	tool	tool	PROPN
aiua-5924	13	52	.	.	PUNCT
aiua-5924	14	1	according	accord	VERB
aiua-5924	14	2	to	to	ADP
aiua-5924	14	3	the	the	DET
aiua-5924	14	4	opinion	opinion	NOUN
aiua-5924	14	5	of	of	ADP
aiua-5924	14	6	the	the	DET
aiua-5924	14	7	rob	rob	PROPN
aiua-5924	14	8	evaluators	evaluator	NOUN
aiua-5924	14	9	,	,	PUNCT
aiua-5924	14	10	“	"	PUNCT
aiua-5924	14	11	the	the	DET
aiua-5924	14	12	last	last	ADJ
aiua-5924	14	13	date	date	NOUN
aiua-5924	14	14	a	a	DET
aiua-5924	14	15	patient	patient	NOUN
aiua-5924	14	16	is	be	AUX
aiua-5924	14	17	known	know	VERB
aiua-5924	14	18	to	to	PART
aiua-5924	14	19	be	be	AUX
aiua-5924	14	20	alive	alive	ADJ
aiua-5924	14	21	”	"	PUNCT
aiua-5924	14	22	was	be	AUX
aiua-5924	14	23	not	not	PART
aiua-5924	14	24	a	a	DET
aiua-5924	14	25	detailed	detailed	ADJ
aiua-5924	14	26	,	,	PUNCT
aiua-5924	14	27	unambiguous	unambiguous	ADJ
aiua-5924	14	28	description	description	NOUN
aiua-5924	14	29	of	of	ADP
aiua-5924	14	30	a	a	DET
aiua-5924	14	31	censoring	censor	VERB
aiua-5924	14	32	criterion	criterion	NOUN
aiua-5924	14	33	.	.	PUNCT
aiua-5924	15	1	if	if	SCONJ
aiua-5924	15	2	death	death	NOUN
aiua-5924	15	3	(	(	PUNCT
aiua-5924	15	4	with	with	ADP
aiua-5924	15	5	death	death	NOUN
aiua-5924	15	6	mostly	mostly	ADV
aiua-5924	15	7	occurring	occur	VERB
aiua-5924	15	8	a	a	DET
aiua-5924	15	9	certain	certain	ADJ
aiua-5924	15	10	time	time	NOUN
aiua-5924	15	11	after	after	ADP
aiua-5924	15	12	tumor	tumor	NOUN
aiua-5924	15	13	,	,	PUNCT
aiua-5924	15	14	pain	pain	NOUN
aiua-5924	15	15	,	,	PUNCT
aiua-5924	15	16	or	or	CCONJ
aiua-5924	15	17	psa	psa	NOUN
aiua-5924	15	18	progression	progression	NOUN
aiua-5924	15	19	)	)	PUNCT
aiua-5924	15	20	were	be	AUX
aiua-5924	15	21	considered	consider	VERB
aiua-5924	15	22	as	as	ADP
aiua-5924	15	23	progression	progression	NOUN
aiua-5924	15	24	time	time	NOUN
aiua-5924	15	25	point	point	NOUN
aiua-5924	15	26	,	,	PUNCT
aiua-5924	15	27	the	the	DET
aiua-5924	15	28	risk	risk	NOUN
aiua-5924	15	29	of	of	ADP
aiua-5924	15	30	bias	bias	NOUN
aiua-5924	15	31	would	would	AUX
aiua-5924	15	32	have	have	AUX
aiua-5924	15	33	been	be	AUX
aiua-5924	15	34	rated	rate	VERB
aiua-5924	15	35	as	as	ADV
aiua-5924	15	36	high	high	ADJ
aiua-5924	15	37	.	.	PUNCT
aiua-5924	16	1	again	again	ADV
aiua-5924	16	2	,	,	PUNCT
aiua-5924	16	3	detailed	detailed	ADJ
aiua-5924	16	4	information	information	NOUN
aiua-5924	16	5	featured	feature	VERB
aiua-5924	16	6	in	in	ADP
aiua-5924	16	7	an	an	DET
aiua-5924	16	8	“	"	PUNCT
aiua-5924	16	9	open	open	ADJ
aiua-5924	16	10	access	access	NOUN
aiua-5924	16	11	”	"	PUNCT
aiua-5924	16	12	study	study	NOUN
aiua-5924	16	13	protocol	protocol	NOUN
aiua-5924	16	14	minimizes	minimize	VERB
aiua-5924	16	15	the	the	DET
aiua-5924	16	16	margins	margin	NOUN
aiua-5924	16	17	of	of	ADP
aiua-5924	16	18	uncertainty	uncertainty	NOUN
aiua-5924	16	19	in	in	ADP
aiua-5924	16	20	the	the	DET
aiua-5924	16	21	evaluation	evaluation	NOUN
aiua-5924	16	22	of	of	ADP
aiua-5924	16	23	a	a	DET
aiua-5924	16	24	manuscript	manuscript	NOUN
aiua-5924	16	25	.	.	PUNCT
aiua-5924	17	1	perletti	perletti	PROPN
aiua-5924	17	2	and	and	CCONJ
aiua-5924	17	3	co	co	NOUN
aiua-5924	17	4	-	-	NOUN
aiua-5924	17	5	authors	author	NOUN
aiua-5924	17	6	’	'	PUNCT
aiua-5924	17	7	response	response	NOUN
aiua-5924	17	8	(	(	PUNCT
aiua-5924	17	9	row	row	NOUN
aiua-5924	17	10	7	7	NUM
aiua-5924	17	11	):	):	PUNCT
aiua-5924	17	12	as	as	ADV
aiua-5924	17	13	specified	specify	VERB
aiua-5924	17	14	above	above	ADV
aiua-5924	17	15	,	,	PUNCT
aiua-5924	17	16	an	an	DET
aiua-5924	17	17	unclear	unclear	ADJ
aiua-5924	17	18	risk	risk	NOUN
aiua-5924	17	19	of	of	ADP
aiua-5924	17	20	bias	bias	NOUN
aiua-5924	17	21	is	be	AUX
aiua-5924	17	22	not	not	PART
aiua-5924	17	23	a	a	DET
aiua-5924	17	24	negative	negative	ADJ
aiua-5924	17	25	evaluation	evaluation	NOUN
aiua-5924	17	26	of	of	ADP
aiua-5924	17	27	the	the	DET
aiua-5924	17	28	quality	quality	NOUN
aiua-5924	17	29	of	of	ADP
aiua-5924	17	30	the	the	DET
aiua-5924	17	31	evidence	evidence	NOUN
aiua-5924	17	32	.	.	PUNCT
aiua-5924	18	1	the	the	DET
aiua-5924	18	2	25%/25	25%/25	NUM
aiua-5924	18	3	%	%	NOUN
aiua-5924	18	4	baseline	baseline	ADJ
aiua-5924	18	5	prevalence	prevalence	NOUN
aiua-5924	18	6	of	of	ADP
aiua-5924	18	7	visceral	visceral	ADJ
aiua-5924	18	8	disease	disease	NOUN
aiua-5924	18	9	is	be	AUX
aiua-5924	18	10	shown	show	VERB
aiua-5924	18	11	in	in	ADP
aiua-5924	18	12	table	table	NOUN
aiua-5924	18	13	1	1	NUM
aiua-5924	18	14	.	.	PUNCT
aiua-5924	19	1	the	the	DET
aiua-5924	19	2	bahl	bahl	PROPN
aiua-5924	19	3	et	et	PROPN
aiua-5924	19	4	al	al	PROPN
aiua-5924	19	5	.	.	PROPN
aiua-5924	19	6	2013	2013	NUM
aiua-5924	19	7	paper	paper	NOUN
aiua-5924	19	8	(	(	PUNCT
aiua-5924	19	9	ann	ann	PROPN
aiua-5924	19	10	oncol	oncol	PROPN
aiua-5924	19	11	.	.	PUNCT
aiua-5924	20	1	2013	2013	NUM
aiua-5924	20	2	sep	sep	NOUN
aiua-5924	20	3	;	;	PUNCT
aiua-5924	20	4	24(9):2402	24(9):2402	NUM
aiua-5924	20	5	-	-	SYM
aiua-5924	20	6	8)	8)	NUM
aiua-5924	20	7	reports	report	VERB
aiua-5924	20	8	that	that	SCONJ
aiua-5924	20	9	for	for	ADP
aiua-5924	20	10	the	the	DET
aiua-5924	20	11	updated	update	VERB
aiua-5924	20	12	>	>	X
aiua-5924	20	13	2y	2y	PROPN
aiua-5924	20	14	os	os	NOUN
aiua-5924	20	15	analysis	analysis	NOUN
aiua-5924	20	16	baseline	baseline	VERB
aiua-5924	20	17	visceral	visceral	ADJ
aiua-5924	20	18	disease	disease	NOUN
aiua-5924	20	19	was	be	AUX
aiua-5924	20	20	present	present	ADJ
aiua-5924	20	21	in	in	ADP
aiua-5924	20	22	15	15	NUM
aiua-5924	20	23	%	%	NOUN
aiua-5924	20	24	and	and	CCONJ
aiua-5924	20	25	19.4	19.4	NUM
aiua-5924	20	26	%	%	NOUN
aiua-5924	20	27	patients	patient	NOUN
aiua-5924	20	28	in	in	ADP
aiua-5924	20	29	the	the	DET
aiua-5924	20	30	cabazitaxel	cabazitaxel	PROPN
aiua-5924	20	31	and	and	CCONJ
aiua-5924	20	32	mitoxantrone	mitoxantrone	ADJ
aiua-5924	20	33	arms	arm	NOUN
aiua-5924	20	34	,	,	PUNCT
aiua-5924	20	35	respectively	respectively	ADV
aiua-5924	20	36	.	.	PUNCT
aiua-5924	21	1	the	the	DET
aiua-5924	21	2	figures	figure	NOUN
aiua-5924	21	3	are	be	AUX
aiua-5924	21	4	too	too	ADV
aiua-5924	21	5	small	small	ADJ
aiua-5924	21	6	to	to	PART
aiua-5924	21	7	allow	allow	VERB
aiua-5924	21	8	evaluation	evaluation	NOUN
aiua-5924	21	9	of	of	ADP
aiua-5924	21	10	the	the	DET
aiua-5924	21	11	reasons	reason	NOUN
aiua-5924	21	12	for	for	ADP
aiua-5924	21	13	such	such	ADJ
aiua-5924	21	14	(	(	PUNCT
aiua-5924	21	15	likely	likely	ADJ
aiua-5924	21	16	accidental	accidental	ADJ
aiua-5924	21	17	)	)	PUNCT
aiua-5924	21	18	out	out	ADP
aiua-5924	21	19	-	-	PUNCT
aiua-5924	21	20	selection	selection	NOUN
aiua-5924	21	21	of	of	ADP
aiua-5924	21	22	patients	patient	NOUN
aiua-5924	21	23	with	with	ADP
aiua-5924	21	24	baseline	baseline	ADJ
aiua-5924	21	25	visceral	visceral	ADJ
aiua-5924	21	26	disease	disease	NOUN
aiua-5924	21	27	in	in	ADP
aiua-5924	21	28	the	the	DET
aiua-5924	21	29	cabazitaxel	cabazitaxel	PROPN
aiua-5924	21	30	arm	arm	PROPN
aiua-5924	21	31	.	.	PUNCT
aiua-5924	22	1	perletti	perletti	PROPN
aiua-5924	22	2	and	and	CCONJ
aiua-5924	22	3	co	co	NOUN
aiua-5924	22	4	-	-	NOUN
aiua-5924	22	5	authors	author	NOUN
aiua-5924	22	6	’	'	PUNCT
aiua-5924	22	7	response	response	NOUN
aiua-5924	22	8	(	(	PUNCT
aiua-5924	22	9	remark	remark	NOUN
aiua-5924	22	10	1	1	NUM
aiua-5924	22	11	):	):	PUNCT
aiua-5924	22	12	we	we	PRON
aiua-5924	22	13	regret	regret	VERB
aiua-5924	22	14	this	this	DET
aiua-5924	22	15	omission	omission	NOUN
aiua-5924	22	16	.	.	PUNCT
aiua-5924	23	1	indeed	indeed	ADV
aiua-5924	23	2	,	,	PUNCT
aiua-5924	23	3	the	the	DET
aiua-5924	23	4	time	time	NOUN
aiua-5924	23	5	-	-	PUNCT
aiua-5924	23	6	to	to	ADP
aiua-5924	23	7	tumor	tumor	NOUN
aiua-5924	23	8	progression	progression	NOUN
aiua-5924	23	9	is	be	AUX
aiua-5924	23	10	aligned	align	VERB
aiua-5924	23	11	with	with	ADP
aiua-5924	23	12	the	the	DET
aiua-5924	23	13	rpfs	rpfs	NOUN
aiua-5924	23	14	definition	definition	NOUN
aiua-5924	23	15	,	,	PUNCT
aiua-5924	23	16	and	and	CCONJ
aiua-5924	23	17	the	the	DET
aiua-5924	23	18	hazard	hazard	NOUN
aiua-5924	23	19	ratio	ratio	NOUN
aiua-5924	23	20	and	and	CCONJ
aiua-5924	23	21	confidence	confidence	NOUN
aiua-5924	23	22	interval	interval	NOUN
aiua-5924	23	23	for	for	ADP
aiua-5924	23	24	this	this	DET
aiua-5924	23	25	endpoint	endpoint	NOUN
aiua-5924	23	26	(	(	PUNCT
aiua-5924	23	27	0.61	0.61	NUM
aiua-5924	23	28	;	;	PUNCT
aiua-5924	23	29	95	95	NUM
aiua-5924	23	30	%	%	NOUN
aiua-5924	23	31	ci:0.49	ci:0.49	PROPN
aiua-5924	23	32	to	to	ADP
aiua-5924	23	33	0.76	0.76	NUM
aiua-5924	23	34	;	;	PUNCT
aiua-5924	23	35	p	p	X
aiua-5924	23	36	<	<	X
aiua-5924	23	37	0.0001	0.0001	NUM
aiua-5924	23	38	)	)	PUNCT
aiua-5924	23	39	could	could	AUX
aiua-5924	23	40	have	have	AUX
aiua-5924	23	41	been	be	AUX
aiua-5924	23	42	added	add	VERB
aiua-5924	23	43	to	to	ADP
aiua-5924	23	44	the	the	DET
aiua-5924	23	45	plot	plot	NOUN
aiua-5924	23	46	in	in	ADP
aiua-5924	23	47	figure	figure	NOUN
aiua-5924	23	48	3	3	NUM
aiua-5924	23	49	.	.	PUNCT
aiua-5924	24	1	no	no	DET
aiua-5924	24	2	further	further	ADJ
aiua-5924	24	3	assessment	assessment	NOUN
aiua-5924	24	4	was	be	AUX
aiua-5924	24	5	however	however	ADV
aiua-5924	24	6	possible	possible	ADJ
aiua-5924	24	7	,	,	PUNCT
aiua-5924	24	8	as	as	SCONJ
aiua-5924	24	9	pooled	pool	VERB
aiua-5924	24	10	analysis	analysis	NOUN
aiua-5924	24	11	of	of	ADP
aiua-5924	24	12	rpfs	rpf	NOUN
aiua-5924	24	13	was	be	AUX
aiua-5924	24	14	only	only	ADV
aiua-5924	24	15	performed	perform	VERB
aiua-5924	24	16	for	for	ADP
aiua-5924	24	17	studies	study	NOUN
aiua-5924	24	18	including	include	VERB
aiua-5924	24	19	anti	anti	ADJ
aiua-5924	24	20	-	-	ADJ
aiua-5924	24	21	androgen	androgen	ADJ
aiua-5924	24	22	agents	agent	NOUN
aiua-5924	24	23	versus	versus	ADP
aiua-5924	24	24	placebo	placebo	NOUN
aiua-5924	24	25	.	.	PUNCT
aiua-5924	25	1	perletti	perletti	PROPN
aiua-5924	25	2	and	and	CCONJ
aiua-5924	25	3	co	co	NOUN
aiua-5924	25	4	-	-	NOUN
aiua-5924	25	5	authors	author	NOUN
aiua-5924	25	6	’	'	PUNCT
aiua-5924	25	7	response	response	NOUN
aiua-5924	25	8	(	(	PUNCT
aiua-5924	25	9	remark	remark	NOUN
aiua-5924	25	10	2	2	NUM
aiua-5924	25	11	,	,	PUNCT
aiua-5924	25	12	item	item	NOUN
aiua-5924	25	13	1	1	NUM
aiua-5924	25	14	):	):	PUNCT
aiua-5924	25	15	a	a	DET
aiua-5924	25	16	comparison	comparison	NOUN
aiua-5924	25	17	was	be	AUX
aiua-5924	25	18	not	not	PART
aiua-5924	25	19	made	make	VERB
aiua-5924	25	20	nor	nor	CCONJ
aiua-5924	25	21	attempted	attempt	VERB
aiua-5924	25	22	in	in	ADP
aiua-5924	25	23	that	that	DET
aiua-5924	25	24	sentence	sentence	NOUN
aiua-5924	25	25	,	,	PUNCT
aiua-5924	25	26	which	which	PRON
aiua-5924	25	27	was	be	AUX
aiua-5924	25	28	simply	simply	ADV
aiua-5924	25	29	summarizing	summarize	VERB
aiua-5924	25	30	,	,	PUNCT
aiua-5924	25	31	at	at	ADP
aiua-5924	25	32	the	the	DET
aiua-5924	25	33	beginning	beginning	NOUN
aiua-5924	25	34	of	of	ADP
aiua-5924	25	35	the	the	DET
aiua-5924	25	36	discussion	discussion	NOUN
aiua-5924	25	37	section	section	NOUN
aiua-5924	25	38	,	,	PUNCT
aiua-5924	25	39	the	the	DET
aiua-5924	25	40	available	available	ADJ
aiua-5924	25	41	evidence	evidence	NOUN
aiua-5924	25	42	in	in	ADP
aiua-5924	25	43	terms	term	NOUN
aiua-5924	25	44	of	of	ADP
aiua-5924	25	45	overall	overall	ADJ
aiua-5924	25	46	survival	survival	NOUN
aiua-5924	25	47	.	.	PUNCT
aiua-5924	26	1	to	to	PART
aiua-5924	26	2	make	make	VERB
aiua-5924	26	3	clear	clear	ADJ
aiua-5924	26	4	that	that	SCONJ
aiua-5924	26	5	comparisons	comparison	NOUN
aiua-5924	26	6	between	between	ADP
aiua-5924	26	7	such	such	ADJ
aiua-5924	26	8	absolute	absolute	ADJ
aiua-5924	26	9	differences	difference	NOUN
aiua-5924	26	10	are	be	AUX
aiua-5924	26	11	not	not	PART
aiua-5924	26	12	feasible	feasible	ADJ
aiua-5924	26	13	,	,	PUNCT
aiua-5924	26	14	we	we	PRON
aiua-5924	26	15	stated	state	VERB
aiua-5924	26	16	at	at	ADP
aiua-5924	26	17	the	the	DET
aiua-5924	26	18	very	very	ADJ
aiua-5924	26	19	beginning	beginning	NOUN
aiua-5924	26	20	of	of	ADP
aiua-5924	26	21	the	the	DET
aiua-5924	26	22	discussion	discussion	NOUN
aiua-5924	26	23	:	:	PUNCT
aiua-5924	26	24	“	"	PUNCT
aiua-5924	26	25	different	different	ADJ
aiua-5924	26	26	baseline	baseline	NOUN
aiua-5924	26	27	characteristics	characteristic	NOUN
aiua-5924	26	28	between	between	ADP
aiua-5924	26	29	studies	study	NOUN
aiua-5924	26	30	(	(	PUNCT
aiua-5924	26	31	e.g.	e.g.	ADV
aiua-5924	26	32	,	,	PUNCT
aiua-5924	26	33	the	the	DET
aiua-5924	26	34	prevalence	prevalence	NOUN
aiua-5924	26	35	of	of	ADP
aiua-5924	26	36	highly	highly	ADV
aiua-5924	26	37	-	-	PUNCT
aiua-5924	26	38	prognostic	prognostic	ADJ
aiua-5924	26	39	visceral	visceral	ADJ
aiua-5924	26	40	metastases	metastasis	NOUN
aiua-5924	26	41	or	or	CCONJ
aiua-5924	26	42	severe	severe	ADJ
aiua-5924	26	43	pain	pain	NOUN
aiua-5924	26	44	at	at	ADP
aiua-5924	26	45	enrollment	enrollment	NOUN
aiua-5924	26	46	)	)	PUNCT
aiua-5924	26	47	likely	likely	ADV
aiua-5924	26	48	explain	explain	VERB
aiua-5924	26	49	the	the	DET
aiua-5924	26	50	inter	inter	ADJ
aiua-5924	26	51	-	-	ADJ
aiua-5924	26	52	study	study	ADJ
aiua-5924	26	53	variability	variability	NOUN
aiua-5924	26	54	of	of	ADP
aiua-5924	26	55	overall	overall	ADJ
aiua-5924	26	56	survival	survival	NOUN
aiua-5924	26	57	,	,	PUNCT
aiua-5924	26	58	especially	especially	ADV
aiua-5924	26	59	as	as	SCONJ
aiua-5924	26	60	assessed	assess	VERB
aiua-5924	26	61	in	in	ADP
aiua-5924	26	62	the	the	DET
aiua-5924	26	63	control	control	NOUN
aiua-5924	26	64	arms	arm	NOUN
aiua-5924	26	65	of	of	ADP
aiua-5924	26	66	each	each	DET
aiua-5924	26	67	trial	trial	NOUN
aiua-5924	26	68	”	"	PUNCT
aiua-5924	26	69	.	.	PUNCT
aiua-5924	27	1	perletti	perletti	PROPN
aiua-5924	27	2	and	and	CCONJ
aiua-5924	27	3	co	co	NOUN
aiua-5924	27	4	-	-	NOUN
aiua-5924	27	5	authors	author	NOUN
aiua-5924	27	6	’	'	PUNCT
aiua-5924	27	7	response	response	NOUN
aiua-5924	27	8	(	(	PUNCT
aiua-5924	27	9	remark	remark	NOUN
aiua-5924	27	10	2	2	NUM
aiua-5924	27	11	,	,	PUNCT
aiua-5924	27	12	item	item	NOUN
aiua-5924	27	13	2	2	NUM
aiua-5924	27	14	):	):	PUNCT
aiua-5924	27	15	that	that	DET
aiua-5924	27	16	sentence	sentence	NOUN
aiua-5924	27	17	had	have	VERB
aiua-5924	27	18	survival	survival	NOUN
aiua-5924	27	19	as	as	ADP
aiua-5924	27	20	subject	subject	NOUN
aiua-5924	27	21	.	.	PUNCT
aiua-5924	28	1	mitoxantrone	mitoxantrone	NOUN
aiua-5924	28	2	has	have	VERB
aiua-5924	28	3	indeed	indeed	ADV
aiua-5924	28	4	antitumor	antitumor	NOUN
aiua-5924	28	5	activity	activity	NOUN
aiua-5924	28	6	,	,	PUNCT
aiua-5924	28	7	but	but	CCONJ
aiua-5924	28	8	no	no	DET
aiua-5924	28	9	effect	effect	NOUN
aiua-5924	28	10	on	on	ADP
aiua-5924	28	11	survival	survival	NOUN
aiua-5924	28	12	.	.	PUNCT
aiua-5924	29	1	in	in	ADP
aiua-5924	29	2	the	the	DET
aiua-5924	29	3	introduction	introduction	NOUN
aiua-5924	29	4	section	section	NOUN
aiua-5924	29	5	of	of	ADP
aiua-5924	29	6	their	their	PRON
aiua-5924	29	7	report	report	NOUN
aiua-5924	29	8	,	,	PUNCT
aiua-5924	29	9	de	de	X
aiua-5924	29	10	bono	bono	X
aiua-5924	29	11	and	and	CCONJ
aiua-5924	29	12	co	co	NOUN
aiua-5924	29	13	-	-	NOUN
aiua-5924	29	14	authors	author	NOUN
aiua-5924	29	15	state	state	VERB
aiua-5924	29	16	that	that	SCONJ
aiua-5924	29	17	though	though	SCONJ
aiua-5924	29	18	mitoxantrone	mitoxantrone	NOUN
aiua-5924	29	19	could	could	AUX
aiua-5924	29	20	be	be	AUX
aiua-5924	29	21	administered	administer	VERB
aiua-5924	29	22	for	for	ADP
aiua-5924	29	23	its	its	PRON
aiua-5924	29	24	effects	effect	NOUN
aiua-5924	29	25	on	on	ADP
aiua-5924	29	26	the	the	DET
aiua-5924	29	27	quality	quality	NOUN
aiua-5924	29	28	of	of	ADP
aiua-5924	29	29	life	life	NOUN
aiua-5924	29	30	,	,	PUNCT
aiua-5924	29	31	at	at	ADP
aiua-5924	29	32	the	the	DET
aiua-5924	29	33	time	time	NOUN
aiua-5924	29	34	(	(	PUNCT
aiua-5924	29	35	year	year	NOUN
aiua-5924	29	36	2010	2010	NUM
aiua-5924	29	37	)	)	PUNCT
aiua-5924	30	1	no	no	DET
aiua-5924	30	2	intervention	intervention	NOUN
aiua-5924	30	3	showed	show	VERB
aiua-5924	30	4	to	to	PART
aiua-5924	30	5	increase	increase	VERB
aiua-5924	30	6	survival	survival	NOUN
aiua-5924	30	7	in	in	ADP
aiua-5924	30	8	the	the	DET
aiua-5924	30	9	post	post	ADJ
aiua-5924	30	10	-	-	ADJ
aiua-5924	30	11	docetaxel	docetaxel	ADJ
aiua-5924	30	12	setting	setting	NOUN
aiua-5924	30	13	(	(	PUNCT
aiua-5924	30	14	de	de	X
aiua-5924	30	15	bono	bono	X
aiua-5924	30	16	et	et	PROPN
aiua-5924	30	17	al	al	PROPN
aiua-5924	30	18	.	.	PROPN
aiua-5924	30	19	,	,	PUNCT
aiua-5924	30	20	lancet	lancet	PROPN
aiua-5924	30	21	2010	2010	NUM
aiua-5924	30	22	;	;	PUNCT
aiua-5924	30	23	376:1147	376:1147	NUM
aiua-5924	30	24	-	-	SYM
aiua-5924	30	25	52	52	NUM
aiua-5924	30	26	)	)	PUNCT
aiua-5924	30	27	.	.	PUNCT
aiua-5924	31	1	perletti	perletti	PROPN
aiua-5924	31	2	letter	letter	NOUN
aiua-5924	31	3	ok_stesura	ok_stesura	ADV
aiua-5924	31	4	seveso	seveso	PROPN
aiua-5924	31	5	08/04/16	08/04/16	PROPN
aiua-5924	31	6	11:34	11:34	NUM
aiua-5924	31	7	pagina	pagina	NOUN
aiua-5924	31	8	74	74	NUM
aiua-5924	31	9	75archivio	75archivio	X
aiua-5924	31	10	italiano	italiano	X
aiua-5924	31	11	di	di	X
aiua-5924	31	12	urologia	urologia	PROPN
aiua-5924	31	13	e	e	PROPN
aiua-5924	31	14	andrologia	andrologia	NOUN
aiua-5924	31	15	2016	2016	NUM
aiua-5924	31	16	;	;	PUNCT
aiua-5924	31	17	88	88	NUM
aiua-5924	31	18	,	,	PUNCT
aiua-5924	31	19	1	1	NUM
aiua-5924	31	20	reply	reply	NOUN
aiua-5924	31	21	to	to	ADP
aiua-5924	31	22	the	the	DET
aiua-5924	31	23	letter	letter	NOUN
aiua-5924	31	24	to	to	ADP
aiua-5924	31	25	the	the	DET
aiua-5924	31	26	editors	editor	NOUN
aiua-5924	31	27	references	reference	NOUN
aiua-5924	31	28	1	1	NUM
aiua-5924	31	29	.	.	X
aiua-5924	31	30	de	de	X
aiua-5924	31	31	bono	bono	X
aiua-5924	31	32	js	js	PROPN
aiua-5924	31	33	,	,	PUNCT
aiua-5924	31	34	oudard	oudard	ADJ
aiua-5924	31	35	s	s	PROPN
aiua-5924	31	36	,	,	PUNCT
aiua-5924	31	37	ozguroglu	ozguroglu	PROPN
aiua-5924	31	38	m	m	PROPN
aiua-5924	31	39	,	,	PUNCT
aiua-5924	31	40	et	et	PROPN
aiua-5924	31	41	al	al	PROPN
aiua-5924	31	42	.	.	PROPN
aiua-5924	31	43	prednisone	prednisone	PROPN
aiua-5924	31	44	plus	plus	CCONJ
aiua-5924	31	45	cabazitaxel	cabazitaxel	PROPN
aiua-5924	31	46	or	or	CCONJ
aiua-5924	31	47	mitoxantrone	mitoxantrone	NOUN
aiua-5924	31	48	for	for	ADP
aiua-5924	31	49	metastatic	metastatic	ADJ
aiua-5924	31	50	castration	castration	NOUN
aiua-5924	31	51	-	-	PUNCT
aiua-5924	31	52	resistant	resistant	ADJ
aiua-5924	31	53	prostate	prostate	NOUN
aiua-5924	31	54	cancer	cancer	NOUN
aiua-5924	31	55	progressing	progressing	NOUN
aiua-5924	31	56	after	after	ADP
aiua-5924	31	57	docetaxel	docetaxel	NOUN
aiua-5924	31	58	treatment	treatment	NOUN
aiua-5924	31	59	:	:	PUNCT
aiua-5924	31	60	a	a	DET
aiua-5924	31	61	randomized	randomize	VERB
aiua-5924	31	62	open	open	ADJ
aiua-5924	31	63	-	-	PUNCT
aiua-5924	31	64	label	label	NOUN
aiua-5924	31	65	trial	trial	NOUN
aiua-5924	31	66	.	.	PUNCT
aiua-5924	32	1	lancet	lancet	PROPN
aiua-5924	32	2	.	.	PUNCT
aiua-5924	33	1	2010	2010	NUM
aiua-5924	33	2	;	;	PUNCT
aiua-5924	33	3	376:1147	376:1147	NUM
aiua-5924	33	4	-	-	SYM
aiua-5924	33	5	54	54	NUM
aiua-5924	33	6	.	.	PUNCT
aiua-5924	34	1	2	2	NUM
aiua-5924	34	2	.	.	X
aiua-5924	35	1	bahl	bahl	PROPN
aiua-5924	35	2	a	a	PRON
aiua-5924	35	3	,	,	PUNCT
aiua-5924	35	4	oudard	oudard	ADJ
aiua-5924	35	5	s	s	PROPN
aiua-5924	35	6	,	,	PUNCT
aiua-5924	35	7	tombal	tombal	PROPN
aiua-5924	35	8	b	b	NOUN
aiua-5924	35	9	,	,	PUNCT
aiua-5924	35	10	et	et	PROPN
aiua-5924	35	11	al	al	PROPN
aiua-5924	35	12	.	.	PROPN
aiua-5924	35	13	impact	impact	NOUN
aiua-5924	35	14	of	of	ADP
aiua-5924	35	15	cabazitaxel	cabazitaxel	PROPN
aiua-5924	35	16	on	on	ADP
aiua-5924	35	17	2	2	NUM
aiua-5924	35	18	-	-	PUNCT
aiua-5924	35	19	year	year	NOUN
aiua-5924	35	20	survival	survival	NOUN
aiua-5924	35	21	and	and	CCONJ
aiua-5924	35	22	palliation	palliation	NOUN
aiua-5924	35	23	of	of	ADP
aiua-5924	35	24	tumour	tumour	NOUN
aiua-5924	35	25	-	-	PUNCT
aiua-5924	35	26	related	relate	VERB
aiua-5924	35	27	pain	pain	NOUN
aiua-5924	35	28	in	in	ADP
aiua-5924	35	29	men	man	NOUN
aiua-5924	35	30	with	with	ADP
aiua-5924	35	31	metastatic	metastatic	ADJ
aiua-5924	35	32	castration	castration	NOUN
aiua-5924	35	33	-	-	PUNCT
aiua-5924	35	34	resistant	resistant	ADJ
aiua-5924	35	35	prostate	prostate	NOUN
aiua-5924	35	36	cancer	cancer	NOUN
aiua-5924	35	37	treated	treat	VERB
aiua-5924	35	38	in	in	ADP
aiua-5924	35	39	the	the	DET
aiua-5924	35	40	tropic	tropic	NOUN
aiua-5924	35	41	trial	trial	NOUN
aiua-5924	35	42	.	.	PUNCT
aiua-5924	36	1	ann	ann	PROPN
aiua-5924	36	2	oncol	oncol	PROPN
aiua-5924	36	3	.	.	PUNCT
aiua-5924	37	1	2013	2013	NUM
aiua-5924	37	2	;	;	PUNCT
aiua-5924	37	3	24:2402	24:2402	X
aiua-5924	37	4	-	-	SYM
aiua-5924	37	5	8	8	NUM
aiua-5924	37	6	.	.	NOUN
aiua-5924	38	1	3	3	X
aiua-5924	38	2	.	.	X
aiua-5924	38	3	therasse	therasse	PROPN
aiua-5924	38	4	p	p	NOUN
aiua-5924	38	5	,	,	PUNCT
aiua-5924	38	6	arbuck	arbuck	ADJ
aiua-5924	38	7	sg	sg	PROPN
aiua-5924	38	8	,	,	PUNCT
aiua-5924	38	9	eisenhauer	eisenhauer	NOUN
aiua-5924	38	10	ea	ea	PROPN
aiua-5924	38	11	,	,	PUNCT
aiua-5924	38	12	et	et	PROPN
aiua-5924	38	13	al	al	PROPN
aiua-5924	38	14	.	.	PUNCT
aiua-5924	39	1	new	new	ADJ
aiua-5924	39	2	guidelines	guideline	NOUN
aiua-5924	39	3	to	to	PART
aiua-5924	39	4	evaluate	evaluate	VERB
aiua-5924	39	5	the	the	DET
aiua-5924	39	6	response	response	NOUN
aiua-5924	39	7	to	to	ADP
aiua-5924	39	8	treatment	treatment	NOUN
aiua-5924	39	9	in	in	ADP
aiua-5924	39	10	solid	solid	ADJ
aiua-5924	39	11	tumors	tumor	NOUN
aiua-5924	39	12	.	.	PUNCT
aiua-5924	40	1	european	european	ADJ
aiua-5924	40	2	organization	organization	PROPN
aiua-5924	40	3	for	for	ADP
aiua-5924	40	4	research	research	NOUN
aiua-5924	40	5	and	and	CCONJ
aiua-5924	40	6	treatment	treatment	NOUN
aiua-5924	40	7	of	of	ADP
aiua-5924	40	8	cancer	cancer	NOUN
aiua-5924	40	9	,	,	PUNCT
aiua-5924	40	10	national	national	PROPN
aiua-5924	40	11	cancer	cancer	PROPN
aiua-5924	40	12	institute	institute	PROPN
aiua-5924	40	13	of	of	ADP
aiua-5924	40	14	the	the	DET
aiua-5924	40	15	united	united	PROPN
aiua-5924	40	16	states	states	PROPN
aiua-5924	40	17	,	,	PUNCT
aiua-5924	40	18	national	national	PROPN
aiua-5924	40	19	cancer	cancer	PROPN
aiua-5924	40	20	institute	institute	PROPN
aiua-5924	40	21	of	of	ADP
aiua-5924	40	22	canada	canada	PROPN
aiua-5924	40	23	.	.	PUNCT
aiua-5924	41	1	j	j	PROPN
aiua-5924	41	2	natl	natl	PROPN
aiua-5924	41	3	cancer	cancer	PROPN
aiua-5924	41	4	inst	inst	PROPN
aiua-5924	41	5	.	.	PROPN
aiua-5924	41	6	2000	2000	NUM
aiua-5924	41	7	;	;	PUNCT
aiua-5924	41	8	92:205	92:205	NUM
aiua-5924	41	9	-	-	SYM
aiua-5924	41	10	16	16	NUM
aiua-5924	41	11	.	.	PUNCT
aiua-5924	42	1	gianpaolo	gianpaolo	PROPN
aiua-5924	42	2	perletti	perletti	PROPN
aiua-5924	42	3	department	department	PROPN
aiua-5924	42	4	of	of	ADP
aiua-5924	42	5	biotechnology	biotechnology	NOUN
aiua-5924	42	6	and	and	CCONJ
aiua-5924	42	7	life	life	NOUN
aiua-5924	42	8	sciences	science	NOUN
aiua-5924	42	9	,	,	PUNCT
aiua-5924	42	10	section	section	NOUN
aiua-5924	42	11	of	of	ADP
aiua-5924	42	12	medical	medical	ADJ
aiua-5924	42	13	and	and	CCONJ
aiua-5924	42	14	surgical	surgical	ADJ
aiua-5924	42	15	sciences	science	NOUN
aiua-5924	42	16	,	,	PUNCT
aiua-5924	42	17	università	università	PROPN
aiua-5924	42	18	degli	degli	PROPN
aiua-5924	42	19	studi	studi	PROPN
aiua-5924	42	20	dell’insubria	dell’insubria	PROPN
aiua-5924	42	21	,	,	PUNCT
aiua-5924	42	22	busto	busto	NOUN
aiua-5924	42	23	a.	a.	PROPN
aiua-5924	42	24	,	,	PUNCT
aiua-5924	42	25	varese	varese	PROPN
aiua-5924	42	26	,	,	PUNCT
aiua-5924	42	27	italy	italy	PROPN
aiua-5924	42	28	department	department	PROPN
aiua-5924	42	29	of	of	ADP
aiua-5924	42	30	basic	basic	ADJ
aiua-5924	42	31	medical	medical	ADJ
aiua-5924	42	32	sciences	sciences	PROPN
aiua-5924	42	33	,	,	PUNCT
aiua-5924	42	34	ghent	ghent	PROPN
aiua-5924	42	35	university	university	PROPN
aiua-5924	42	36	,	,	PUNCT
aiua-5924	42	37	ghent	ghent	NOUN
aiua-5924	42	38	,	,	PUNCT
aiua-5924	42	39	belgium	belgium	NOUN
aiua-5924	42	40	correspondence	correspondence	NOUN
aiua-5924	42	41	gianpaolo	gianpaolo	PROPN
aiua-5924	42	42	perletti	perletti	PROPN
aiua-5924	42	43	,	,	PUNCT
aiua-5924	42	44	phd	phd	PROPN
aiua-5924	42	45	gianpaolo.perletti@uninsubria.it	gianpaolo.perletti@uninsubria.it	PROPN
aiua-5924	42	46	department	department	PROPN
aiua-5924	42	47	of	of	ADP
aiua-5924	42	48	biotechnology	biotechnology	NOUN
aiua-5924	42	49	and	and	CCONJ
aiua-5924	42	50	life	life	NOUN
aiua-5924	42	51	sciences	science	NOUN
aiua-5924	42	52	università	università	PROPN
aiua-5924	42	53	degli	degli	PROPN
aiua-5924	42	54	studi	studi	PROPN
aiua-5924	42	55	dell’insubria	dell’insubria	PROPN
aiua-5924	42	56	via	via	ADP
aiua-5924	42	57	a.	a.	NOUN
aiua-5924	42	58	da	da	PROPN
aiua-5924	42	59	giussano	giussano	PROPN
aiua-5924	42	60	,	,	PUNCT
aiua-5924	42	61	10	10	NUM
aiua-5924	42	62	21052	21052	NUM
aiua-5924	42	63	busto	busto	NOUN
aiua-5924	42	64	arsizio	arsizio	NOUN
aiua-5924	42	65	,	,	PUNCT
aiua-5924	42	66	italy	italy	PROPN
aiua-5924	42	67	perletti	perletti	PROPN
aiua-5924	42	68	letter	letter	NOUN
aiua-5924	42	69	ok_stesura	ok_stesura	ADV
aiua-5924	42	70	seveso	seveso	PROPN
aiua-5924	42	71	08/04/16	08/04/16	PROPN
aiua-5924	42	72	11:34	11:34	NUM
aiua-5924	42	73	pagina	pagina	NOUN
aiua-5924	42	74	75	75	NUM